Miracle-dz/UniFAR-FTUs huggingface dataset:
The Digitization of Word-of-Mouth: Promise and Challenges of Online Reputation Systems

Online reputation mechanisms are emerging as a promising alternative to more traditional trust building mechanisms, such as branding and formal contracting, in settings where the latter may be ineffective or prohibitively expensive; a lot of electronic trading communities fall under these categories. Although a number of commercial websites already employ various forms of reputation mechanisms, rigorous research into their properties is still in its infancy. This fledgling field can benefit from past results in economics and game theory. Moreover, in order to translate the stylized results of game theory into concrete managerial guidance for implementing and participating in effective reputation mechanisms further advances are needed in a number of important areas: First, the design space of such mechanisms needs to be scoped and the effects of different design choices on performance need to be better understood. Second, the economic efficiency of various classes of reputation mechanisms needs to be quantified and compared to that of alternative mechanisms for building trust. Third, the robustness of those mechanisms against boundedly rational players, noisy ratings and strategic manipulation needs to be studied and improved. This paper surveys past results that have been derived in a variety of contexts, but which are relevant as a basis for building online reputation systems, presents two analytical models that illustrate the role of such systems in electronic markets and identifies opportunities for further MS/OR research in this fascinating area. 1 Preliminary draft of December 10, 2001 for comments and discussion. Please do not circulate.
Prodrugs for Gene-Directed Enzyme-Prodrug Therapy (Suicide Gene Therapy)

This review focuses on the prodrugs used in suicide gene therapy. These prodrugs need to satisfy a number of criteria. They must be efficient and selective substrates for the activating enzyme, and be metabolized to potent cytotoxins preferably able to kill cells at all stages of the cell cycle. Both prodrugs and their activated species should have good distributive properties, so that the resulting bystander effects can maximize the effectiveness of the therapy, since gene transduction efficiencies are generally low. A total of 42 prodrugs explored for use in suicide gene therapy with 12 different enzymes are discussed, particularly in terms of their physiocochemical properties. An important parameter in determining bystander effects generated by passive diffusion is the lipophilicity of the activated form, a property conveniently compared by diffusion coefficients (log P for nonionizable compounds and log D7 for compounds containing an ionizable centre). Many of the early antimetabolite-based prodrugs provide very polar activated forms that have limited abilities to diffuse across cell membranes, and rely on gap junctions between cells for their bystander effects. Several later studies have shown that more lipophilic, neutral compounds have superior diffusion-based bystander effects. Prodrugs of DNA alkylating agents, that are less cell cycle-specific than antimetabolites and more effective against noncycling tumor cells, appear in general to be more active prodrugs, requiring less prolonged dosing schedules to be effective. It is expected that continued studies to optimize the bystander effects and other properties of prodrugs and the activated species they generate will contribute to improvements in the effectiveness of suicide gene therapy.
Corticostriatal circuitry

Corticostriatal connections play a central role in developing appropriate goal-directed behaviors, including the motivation and cognition to develop appropriate actions to obtain a specific outcome. The cortex projects to the striatum topographically. Thus, different regions of the striatum have been associated with these different functions: the ventral striatum with reward; the caudate nucleus with cognition; and the putamen with motor control. However, corticostriatal connections are more complex, and interactions between functional territories are extensive. These interactions occur in specific regions in which convergence of terminal fields from different functional cortical regions are found. This article provides an overview of the connections of the cortex to the striatum and their role in integrating information across reward, cognitive, and motor functions. Emphasis is placed on the interface between functional domains within the striatum.
Predictive gradient iterative learning control

Iterative learning control (ILC) is a control design method for high performance trajectory tracking. Most existing results achieve this by learning from information collected over past executions of the task (named trials). This paper proposes a novel gradient based ILC design which updates the control input by learning not only from past trials but also from the predicted future trials using plant model knowledge. It is shown that by including information from predicted future trials, the designed ILC controller is less short-sighted and therefore better performance can be achieved. Analysis of the algorithm's properties reveals potentially substantial benefit in terms of convergence speed; the proposed algorithm also possesses distinct robustness features with respect to model uncertainty. Numerical simulations are provided to demonstrate the effectiveness of the proposed method.
2-dimensional ion velocity distributions measured by laser-induced fluorescence above a radio-frequency biased silicon wafer

The dynamics of ions traversing sheaths in low temperature plasmas are important to the formation of the ion energy distribution incident onto surfaces during microelectronics fabrication. Ion dynamics have been measured using laser-induced fluorescence (LIF) in the sheath above a 30 cm diameter, 2.2 MHz-biased silicon wafer in a commercial inductively coupled plasma processing reactor. The velocity distribution of argon ions was measured at thousands of positions above and radially along the surface of the wafer by utilizing a planar laser sheet from a pulsed, tunable dye laser. Velocities were measured both parallel and perpendicular to the wafer over an energy range of 0.4–600 eV. The resulting fluorescence was recorded using a fast CCD camera, which provided resolution of 0.4 mm in space and 30 ns in time. Data were taken at eight different phases during the 2.2 MHz cycle. The ion velocity distributions (IVDs) in the sheath were found to be spatially non-uniform near the edge of the wafer and phase-de.
Prediction and characterization of an Mg-Al intermetallic compound with potentially improved ductility via orbital-free and Kohn-Sham density functional theory

Magnesium-aluminum (Mg-Al) intermetallic compounds that form as precipitates can significantly influence the mechanical properties of Mg-Al alloys. A computational evaluation of known and unknown Mg-Al intermetallic compounds could help design new Mg-Al alloy microstructures with optimal properties. Here, we employ the cluster-expansion method with energies efficiently calculated with orbital-free density functional theory (OFDFT) and predict a new, metastable intermetallic compound Mg3Al with a D019 hexagonal structure that is slightly more stable than an alternative L12 cubic structure. We apply Kohn-Sham DFT (KSDFT) to accurately evaluate various metastability criteria for D019 and L12 Mg3Al, including Born’s criterion and phonon dispersion. We show that both Mg3Al crystalline phases satisfy the metastability criteria and hence should be at least metastable. We further compare ductility metrics for D019 and L12 Mg3Al to that of hexagonal-close-packed Mg by computing Pugh’s ratio and generalized stacking fault energies. The ductility is predicted to follow the order: D019 Mg3Al > L12 Mg3Al > Mg, based on the highest Pugh’s ratio and the lowest unstable stacking and twinning fault energies of D019 Mg3Al compared to that of Mg. We also predict a very low antiphase boundary energy for Mg3Al and therefore expect D019 Mg3Al to be beneficial for improving the ductility of Mg-rich Mg-Al alloys. A computational design of Mg-Al alloy microstructures may become possible by combining the strengths of both OFDFT and KSDFT, i.e., the efficiency of the former and the accuracy of the latter, as demonstrated here.
Interocular temporal delay sensitivity in the visual cortex of the awake monkey

Due to the separation of the eyes, temporal retinal disparities are created during binocular stimulation and they have been proposed to be the basis of several stereo‐visual effects. This paper studies the sensitivity of cortical neurons from area V1 to interocular temporal delay in the awake monkey (Macaca mulatta). Forty‐four cells were included in this study. Temporal delay sensitivity was observed in 59% of them. About half of these temporal‐delay‐sensitive cells were also sensitive to the stimulation sequence of the eyes. The cells that preferred one eye to be stimulated first were termed asymmetrical (46%); those which were not sensitive to the eye sequence of stimulation were termed symmetrical (54%). No clear differences were observed in the distribution of delay‐sensitive cells according to their eye dominance. Fifty‐six percent of balanced cells and 65% of unbalanced cells were sensitive to interocular delay. These data underline the importance of temporal cues for depth perception.
Shear modulus reduction and material damping relations for municipal solid-waste

Results of laboratory tests are presented for the evaluation of dynamic properties of Municipal Solid-Waste (MSW) from the Tri-Cities landfill in the San Francisco Bay Area. Values of small-strain shear modulus, Gmax, and the normalized shear modulus reduction and material damping ratio curves are measured using large-scale cyclic triaxial tests. The test results, which are considered representative for depths up to 20 m, are used for investigating the dependence of the waste material’s dynamic properties on specimen composition, duration of confinement, unit weight of material, and loading frequency.
Validating an iOS-based Rhythmic Auditory Cueing Evaluation (iRACE) for Parkinson's Disease

Movement disorders such as Parkinson's disease (PD) will affect a rapidly growing segment of the population as society continues to age. Rhythmic Auditory Cueing (RAC) is a well-supported evidence-based intervention for the treatment of gait impairments in PD. RAC interventions have not been widely adopted, however, due to limitations in access to personnel, technological, and financial resources. To help "scale up" RAC for wider distribution, we have developed an iOS-based Rhythmic Auditory Cueing Evaluation (iRACE) mobile application to deliver RAC and assess motor performance in PD patients. The touchscreen of the mobile device is used to assess motor timing during index finger tapping, and the device's built-in tri-axial accelerometer and gyroscope to assess step time and step length during walking. Novel machine learning-based gait analysis algorithms have been developed for iRACE, including heel strike detection, step length quantification, and left-versus-right foot identification. The concurrent validity of iRACE was assessed using a clinic-standard instrumented walking mat and a pair of force-sensing resistor sensors. Results from 10 PD patients reveal that iRACE has low error rates (<±1.0%) across a set of four clinically relevant outcome measures, indicating a potentially useful clinical tool.
Ultrafine particle size distribution during high velocity impact of high density metals

In the event of high-energy penetrator impact, people involved in battlefield scenarios are exposed to the additional hazard stemming from ultrafine metallic particles, i.e. exposure, inhalation, and respiration of aerolized metals. In order to have reliable quantitative measurement of the aerosol particles generated under controlled impact conditions, an experimental set-up was designed to perform impact tests with light gas-gun in chamber. During the impact events, aerosol particle size distributions and total concentrations were measured with a one-second time resolution. In this study preliminary results relative to high purity copper projectile impact at different velocities are presented.
Rotavirus and Serotonin Cross-Talk in Diarrhoea

Rotavirus (RV) has been shown to infect and stimulate secretion of serotonin from human enterochromaffin (EC) cells and to infect EC cells in the small intestine of mice. It remains to identify which intracellularly expressed viral protein(s) is responsible for this novel property and to further establish the clinical role of serotonin in RV infection. First, we found that siRNA specifically silencing NSP4 (siRNANSP4) significantly attenuated secretion of serotonin from Rhesus rotavirus (RRV) infected EC tumor cells compared to siRNAVP4, siRNAVP6 and siRNAVP7. Second, intracellular calcium mobilization and diarrhoeal capacity from virulent and avirulent porcine viruses correlated with the capacity to release serotonin from EC tumor cells. Third, following administration of serotonin, all (10/10) infants, but no (0/8) adult mice, responded with diarrhoea. Finally, blocking of serotonin receptors using Ondansetron significantly attenuated murine RV (strain EDIM) diarrhoea in infant mice (2.9 vs 4.5 days). Ondansetron-treated mice (n = 11) had significantly (p < 0.05) less diarrhoea, lower diarrhoea severity score and lower total diarrhoea output as compared to mock-treated mice (n = 9). Similarly, Ondansetron-treated mice had better weight gain than mock-treated animals (p < 0.05). A most surprising finding was that the serotonin receptor antagonist significantly (p < 0.05) also attenuated total viral shedding. In summary, we show that intracellularly expressed NSP4 stimulates release of serotonin from human EC tumor cells and that serotonin participates in RV diarrhoea, which can be attenuated by Ondansetron.
Experimental investigation of bond behavior with tension lap splice for deformed steel bars in recycled aggregate concrete

Splice strength of deformed steel bars embedded in recycled aggregate concrete (RAC) was experimentally investigated using 48 bottom-cast scaled splice beam specimens detailed with unconfined contact lap splices and tested under four-point bending. The following variables were investigated: concrete grade (normal- and medium-strength), recycled concrete aggregate replacement level (0, 50, and 100%), rebar diameter (12 and 20 mm), splice length (15 and 25 db), rebar surface characteristics, and concrete cover to rebar diameter (c/db = 1.25 and 2). Bond behavior and failure modes were noted to be similar in the natural and in the RAC and a regression analysis of the results shows that f′c3/4 provides a good representation of the influence of RAC grade on splice strength. A descriptive bond strength equation has been proposed for RAC.
Systematic alanine insertion reveals the essential regions that encode structure formation and activity of dihydrofolate reductase

Decoding sequence information is equivalent to elucidating the design principles of proteins. For this purpose, we conducted systematic alanine insertion analysis to reveal the regions in the primary structure where the sequence continuity cannot be disrupted. We applied this method to dihydrofolate reductase (DHFR), and examined the effects of alanine insertion on structure and the enzymatic activity by solubility assay and trimethoprim resistance, respectively. We revealed that DHFR is composed of “Structure Elements”, “Function Elements” and linkers connecting these elements. The “Elements” are defined as regions where the alanine insertion caused DHFR to become unstructured or inactive. Some “Structure Elements” overlap with “Function Elements”, indicating that loss of structure leads to loss of function. However, other “Structure Elements” are not “Function Elements”, in that alanine insertion mutants of these regions exhibit substrate- or inhibitor-induced folding. There are also some “Function Elements” which are not “Structure Elements”; alanine insertion into these elements deforms the catalytic site topology without the loss of tertiary structure. We hypothesize that these elements are involved essential interactions for structure formation and functional expression. The “Elements” are closely related to the module structure of DHFR. An “Element” belongs to a single module, and a single module is composed of some number of “Elements. ” We propose that properties of a module are determined by the “Elements” it contains. Systematic alanine insertion analysis is an effective and unique method for deriving the regions of a sequence that are essential for structure formation and functional expression.
Reassortment of Human and Animal Rotavirus Gene Segments in Emerging DS-1-Like G1P[8] Rotavirus Strains

The emergence and rapid spread of novel DS-1-like G1P[8] human rotaviruses in Japan were recently reported. More recently, such intergenogroup reassortant strains were identified in Thailand, implying the ongoing spread of unusual rotavirus strains in Asia. During rotavirus surveillance in Thailand, three DS-1-like intergenogroup reassortant strains having G3P[8] (RVA/Human-wt/THA/SKT-281/2013/G3P[8] and RVA/Human-wt/THA/SKT-289/2013/G3P[8]) and G2P[8] (RVA/Human-wt/THA/LS-04/2013/G2P[8]) genotypes were identified in fecal samples from hospitalized children with acute gastroenteritis. In this study, we sequenced and characterized the complete genomes of strains SKT-281, SKT-289, and LS-04. On whole genomic analysis, all three strains exhibited unique genotype constellations including both genogroup 1 and 2 genes: G3-P[8]-I2-R2-C2-M2-A2-N2-T2-E2-H2 for strains SKT-281 and SKT-289, and G2-P[8]-I2-R2-C2-M2-A2-N2-T2-E2-H2 for strain LS-04. Except for the G genotype, the unique genotype constellation of the three strains (P[8]-I2-R2-C2-M2-A2-N2-T2-E2-H2) is commonly shared with DS-1-like G1P[8] strains. On phylogenetic analysis, nine of the 11 genes of strains SKT-281 and SKT-289 (VP4, VP6, VP1-3, NSP1-3, and NSP5) appeared to have originated from DS-1-like G1P[8] strains, while the remaining VP7 and NSP4 genes appeared to be of equine and bovine origin, respectively. Thus, strains SKT-281 and SKT-289 appeared to be reassortant strains as to DS-1-like G1P[8], animal-derived human, and/or animal rotaviruses. On the other hand, seven of the 11 genes of strain LS-04 (VP7, VP6, VP1, VP3, and NSP3-5) appeared to have originated from locally circulating DS-1-like G2P[4] human rotaviruses, while three genes (VP4, VP2, and NSP1) were assumed to be derived from DS-1-like G1P[8] strains. Notably, the remaining NSP2 gene of strain LS-04 appeared to be of bovine origin. Thus, strain LS-04 was assumed to be a multiple reassortment strain as to DS-1-like G1P[8], locally circulating DS-1-like G2P[4], bovine-like human, and/or bovine rotaviruses. Overall, the great genomic diversity among the DS-1-like G1P[8] strains seemed to have been generated through reassortment involving human and animal strains. To our knowledge, this is the first report on whole genome-based characterization of DS-1-like intergenogroup reassortant strains having G3P[8] and G2P[8] genotypes that have emerged in Thailand. Our observations will provide important insights into the evolutionary dynamics of emerging DS-1-like G1P[8] strains and related reassortant ones.
The effects of Hill-Robertson interference between weakly selected mutations on patterns of molecular evolution and variation.

Associations between selected alleles and the genetic backgrounds on which they are found can reduce the efficacy of selection. We consider the extent to which such interference, known as the Hill-Robertson effect, acting between weakly selected alleles, can restrict molecular adaptation and affect patterns of polymorphism and divergence. In particular, we focus on synonymous-site mutations, considering the fate of novel variants in a two-locus model and the equilibrium effects of interference with multiple loci and reversible mutation. We find that weak selection Hill-Robertson (wsHR) interference can considerably reduce adaptation, e.g., codon bias, and, to a lesser extent, levels of polymorphism, particularly in regions of low recombination. Interference causes the frequency distribution of segregating sites to resemble that expected from more weakly selected mutations and also generates specific patterns of linkage disequilibrium. While the selection coefficients involved are small, the fitness consequences of wsHR interference across the genome can be considerable. We suggest that wsHR interference is an important force in the evolution of nonrecombining genomes and may explain the unexpected constancy of codon bias across species of very different census population sizes, as well as several unusual features of codon usage in Drosophila.
Immunology of chronic myeloid leukemia: current concepts and future goals

Although chronic myeloid leukemia is a rare malignancy, it has developed into a model system for the study of a variety of aspects of cancer biology and immunology. The introduction of tyrosine kinase inhibitors has resulted in a significant prolongation of the survival rates of chronic myeloid leukemia patients but has not resulted in a cure. There is a growing conviction that this aim can be achieved through immunotherapy. For this concept to be successful, a considerable increase in the present understanding of chronic myeloid leukemia immunology is required. The authors attempt to review and evaluate the current findings that demonstrate a number of immunological aberrations in patients prior to the start of any therapy and their normalization after achieving remission. They also discuss the recent clinical trials with experimental therapeutic vaccines and then present their own strategy on how to address the problem.
Probabilistic Estimation of Network Size and Diameter

Determining the size of a network and its diameter are important functions in distributed systems, as there are a number of algorithms which rely on such parameters, or at least on estimates of those values. The Extrema Propagation technique allows the estimation of the size of a network in a fast, distributed and fault tolerant manner. The technique was previously studied in a simulation setting where rounds advance synchronously and where there is no message loss. This work presents two main contributions. The first, is the study of the Extrema Propagation technique under asynchronous rounds and integrated in the Network Friendly Epidemic Multicast (NeEM) framework. The second, is the evaluation of a diameter estimation technique associated with the Extrema Propagation. This study also presents a small enhancement to the Extrema Propagation in terms of communication cost and points out some other possible enhancements. Results show that there is a clear trade-off between time and communication that must be considered when configuring the protocol—a faster convergence time implies a higher communication cost. Results also show that its possible to reduce the total communication cost by more than 18% using a simple approach. The diameter estimation technique is shown to have a relative error of less than 10% even when using a small sample of nodes.
Schizoaffective Psychosis: II. Manic, Bipolar, and Depressive Subtypes

• Three schizoaffective subtypes—manic, bipolar, and depressive—were compared across multiple baseline (demographic, premorbid, morbid) and long-term outcome dimensions. Though the subtypes were comparable at baseline, the patients with depressive schizoaffective disorder scored consistently better at follow-up, although none of these differences was statistically significant. Results failed to support the validity of such subtyping in schizoaffective disorder, at least in predominantly chronic populations.