Miracle-dz/UniFAR-FTUs huggingface dataset:
Repetition Suppression for Speech Processing in the Associative Occipital and Parietal Cortex of Congenitally Blind Adults

In the congenitally blind (CB), sensory deprivation results in cross-modal plasticity, with visual cortical activity observed for various auditory tasks. This reorganization has been associated with enhanced auditory abilities and the recruitment of visual brain areas during sound and language processing. The questions we addressed are whether visual cortical activity might also be observed in CB during passive listening to auditory speech and whether cross-modal plasticity is associated with adaptive differences in neuronal populations compared to sighted individuals (SI). We focused on the neural substrate of vowel processing in CB and SI adults using a repetition suppression (RS) paradigm. RS has been associated with enhanced or accelerated neural processing efficiency and synchronous activity between interacting brain regions. We evaluated whether cortical areas in CB were sensitive to RS during repeated vowel processing and whether there were differences across the two groups. In accordance with previous studies, both groups displayed a RS effect in the posterior temporal cortex. In the blind, however, additional occipital, temporal and parietal cortical regions were associated with predictive processing of repeated vowel sounds. The findings suggest a more expanded role for cross-modal compensatory effects in blind persons during sound and speech processing and a functional transfer of specific adaptive properties across neural regions as a consequence of sensory deprivation at birth.
Grief as a Social Emotion: Theoretical Perspectives

The article explores a sociological perspective on grief as a social emotion. Focusing on the social bond with the deceased, the self-concept of the survivor or the power of feeling rules, general sociological theories of emotions (symbolic interactionism, structural theory, behavioral theory) have the potential to deepen the understanding of grief as a social emotion. The article concludes by presenting a cognitive-structural model of grief that integrates the different theoretical elements.
Towards OLAP security design — survey and research issues

With the use of data warehousing and online analytical processing (OLAP) for decision support applications new security issues arise. The goal of this paper is to introduce an OLAP security design methodology, pointing out fields that require further research work. We present possible access control requirements categorized by their complexity. OLAP security mechanisms and their implementations in commercial systems are presented and checked for their suitability to address the requirements. Traditionally data warehouses were queried by high level users (executive management, business analysts) only. As the range of potential users with data warehouse access is steadily growing, this assumption is no longer appropriate and the necessity of proper access control mechanisms arises. However, a data warehouse is primarily built as an open system. Especially exploratory OLAP analysis requires this open nature; security controls may hinder the analytical discovery process.
Inhomogeneous Quadriceps Femoris Hypertrophy in Response to Strength and Power Training.

INTRODUCTION Previous studies have reported inhomogeneous changes in quadriceps femoris (QF) cross-sectional area (CSA) in response to strength training. It is assumed that these differential changes in muscle shape influence the muscle's functional capacity during high-force and high-power movements. The purpose of the current study was to compare intermuscular and intramuscular QF adaptations to high-load strength training and fast-speed power training. METHODS Thirty-six non-strength-trained men were randomly assigned to four groups and completed 8 wk of parallel-depth heavy squat-lift training (HS-P), parallel-depth jump squat training (JS-P), volitional-depth jump squat training (JS-V), or no training (C). Quadriceps femoris, vastus lateralis (VL), intermedius (VI), medialis (VM), and rectus femoris (RF) CSA were measured in distal-, mid-, and proximal-thigh regions using extended field-of-view ultrasonography and compared using a 3 × 2 mixed-model MANOVA with Bonferroni post hoc tests (P < 0.05). RESULTS Parallel-depth heavy squat-lift training and JS-P elicited similar changes in mid-CSA(QF) as well as summed CSA of the QF, VL, VI, and VM. Cross-sectional area of the VL (CSA(VL)) and CSA(VI) increased in both HS-P and JS-P at mid-thigh, but only JS-P significantly increased CSA proximally, and only HS-P significantly increased CSA distally. Cross-sectional area of the VM (CSA(VM)) increased in HS-P and JS-P distally, but only HS-P increased at mid-thigh. No hypertrophy was observed in RF at any location and no significant differences were observed between JS-P and JS-V. Parallel-depth heavy squat-lift training elicited greater proximal hypertrophy in each of the vasti muscles, whereas only JS-P elicited distal VL and VI hypertrophy. CONCLUSIONS These observed inhomogeneous changes in CSA may alter the thigh's moment of inertia and moment arms of muscle "compartments," and the influence of elastic component force transmission on the muscular force expression. Such selective hypertrophy is speculated to be biomechanically beneficial to high-force or high-power movements used in training.
Market Skewness Risk and the Cross-Section of Stock Returns

The cross section of stock returns has substantial exposure to risk captured by higher moments of market returns. We estimate these moments from daily Standard & Poor's 500 index option data. The resulting time series of factors are genuinely conditional and forward-looking. Stocks with high exposure to innovations in implied market skewness exhibit low returns on average. The results are robust to various permutations of the empirical setup. The market skewness risk premium is statistically and economically significant and cannot be explained by other common risk factors such as the market excess return or the size, book-to-market, momentum, and market volatility factors, or by firm characteristics.
Influence of drying schedule on VOC emissions from kiln-drying loblolly pine lumber.

This research investigated potential methods of reducing the total VOC emissions from southern yellow pine lumber drying by modifying the kiln schedule or by using a pretreatment. Three different high-temperature kiln schedules were used: 120°C dry-bulb temperature (DBT) with 96°C wet-bulb temperature (WBT), 120°C DBT with 82°C WBT (control schedule), and 100°C DBT with 82°C WBT. Three pre-treatments were also investigated. One pre-treatment was steaming. In this case, the pine lumber was steamed at 98°C for 4 hours before it was dried. The other pre-treatments used radio-frequency heating by which the lumber was heated in a radio-frequency reactor for 10 and 40 minutes, respectively. Seasonal variation was also investigated across the different treatments. Statistically significant differences were found among the treatments. No statistically significant differences were detected, however, among the seasonal groups.
Intranasal DNA Vaccine for Protection against Respiratory Infectious Diseases: The Delivery Perspectives

Intranasal delivery of DNA vaccines has become a popular research area recently. It offers some distinguished advantages over parenteral and other routes of vaccine administration. Nasal mucosa as site of vaccine administration can stimulate respiratory mucosal immunity by interacting with the nasopharyngeal-associated lymphoid tissues (NALT). Different kinds of DNA vaccines are investigated to provide protection against respiratory infectious diseases including tuberculosis, coronavirus, influenza and respiratory syncytial virus (RSV) etc. DNA vaccines have several attractive development potential, such as producing cross-protection towards different virus subtypes, enabling the possibility of mass manufacture in a relatively short time and a better safety profile. The biggest obstacle to DNA vaccines is low immunogenicity. One of the approaches to enhance the efficacy of DNA vaccine is to improve DNA delivery efficiency. This review provides insight on the development of intranasal DNA vaccine for respiratory infections, with special attention paid to the strategies to improve the delivery of DNA vaccines using non-viral delivery agents.
Cervicovaginal Cytology in the Detection of Recurrence After Cervical Cancer Treatment

OBJECTIVE: To evaluate the utility of liquid-based cytology in detecting recurrent cervical cancer among treated cervical cancer patients. METHODS: A retrospective multi-institution study identified patients treated for cervical cancer from January 1, 2000, to November 1, 2009, through local cancer registries and patient databases. Patients were excluded if they lacked follow-up or treatment data. RESULTS: In all, 4,167 cytology results from 929 women were identified. Of these, 626 (15%) Pap test results from 312 (34%) women were abnormal, including 296 atypical squamous cells of undetermined significance (ASC-US; 47%); 179 low-grade squamous intraepithelial lesions (LSIL; 29%), 59 atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesions (ASC-H; 9%); 55 high-grade squamous intraepithelial lesions (HSIL; 9%); 14 atypical glandular cells (2%), and 23 favor neoplasia (4%). Abnormal Pap test results led to 201 colposcopies in 135 women. Only 45 women had cervical intraepithelial neoplasia (CIN) 2 or worse, 25 had CIN 3, and 12 had cancer. Only 5 of 475 (1%) women with ASC-US or LSIL had CIN 3. Cancer recurred in 147 women, with 12 (8.1%) detected by Pap test; all but one had Pap test results of ASC-H or worse. One patient with ASC-US and human papillomavirus had a visible lesion on return for assessment 2 months after Pap testing. Colposcopy for cytology less than HSIL without a visible lesion on examination did not detect any recurrence or CIN 3. When stratified by stage and institution, patients treated with radiation had a higher risk of abnormal Pap test results (P<.001). CONCLUSION: A third of cervical cancer survivors will have abnormal cytology during follow-up, but in the absence of a visible lesion, those with ASC-US or LSIL can be followed without colposcopy unless abnormalities persist. Women with ASC-H, HSIL, and similar abnormalities deserve colposcopy. LEVEL OF EVIDENCE: II
TRANSITION OF ADOLESCENTS WITH SPECIAL HEALTH CARE NEEDS: REVIEW AND ANALYSIS OF THE LITERATURE

A review and analysis of 43 transition studies published from 1982 through 2003 was conducted. The studies reviewed represent the diverse purposes of international researchers for examining transition issues and questions. Findings of this literature review indicate that transition research is in early stages of development. A number of limitations were associated with these studies, including the lack of theoretical frameworks, the use of valid and reliable instruments, and research designs lacking adequate controls. Future research studies are needed that overcome the design limitations of past investigations.
The genetic architecture of economic and political preferences

Preferences are fundamental building blocks in all models of economic and political behavior. We study a new sample of comprehensively genotyped subjects with data on economic and political preferences and educational attainment. We use dense single nucleotide polymorphism (SNP) data to estimate the proportion of variation in these traits explained by common SNPs and to conduct genome-wide association study (GWAS) and prediction analyses. The pattern of results is consistent with findings for other complex traits. First, the estimated fraction of phenotypic variation that could, in principle, be explained by dense SNP arrays is around one-half of the narrow heritability estimated using twin and family samples. The molecular-genetic–based heritability estimates, therefore, partially corroborate evidence of significant heritability from behavior genetic studies. Second, our analyses suggest that these traits have a polygenic architecture, with the heritable variation explained by many genes with small effects. Our results suggest that most published genetic association studies with economic and political traits are dramatically underpowered, which implies a high false discovery rate. These results convey a cautionary message for whether, how, and how soon molecular genetic data can contribute to, and potentially transform, research in social science. We propose some constructive responses to the inferential challenges posed by the small explanatory power of individual SNPs.
Choice of and satisfaction with methods of medical and surgical abortion among U.S. clinic patients.

CONTEXT Abortion induced by drugs is now a viable alternative to surgically induced abortion for U. S. women. Women's willingness to use these new methods of medical abortion hinges on the extent to which they prove acceptable, however. METHODS Among 304 women participating in a clinical trial of medical abortion, 186 received a methotrexate-induced abortion and 118 were offered the option of a medical abortion but chose a surgical procedure instead. Study participants completed self-administered questionnaires before the abortion and again at a follow-up visit. RESULTS Women in the medical and surgical abortion groups did not differ significantly with regard to demographic and other background characteristics: Their mean age was about 27, more than two-thirds were white, and three-quarters were unmarried and worked either part-time or full-time. However, women's ratings of seven attributes of abortion methods were significant predictors of choosing a medical abortion: Women were more likely to choose medical abortion if they placed greater importance on a method that was nonsurgical, one that resembled a miscarriage or one that could take place at home (odds ratios, 2.0-3.3). Conversely, women were less likely to choose medical abortion if they valued methods that were quick, that did not involve painful cramping or seeing blood or blood clots and that needed a doctor or nurse to be present (odds ratios, 0.3-0.5). Compared with those who had a surgical abortion, women who had a methotrexate-induced abortion expected more bleeding (mean scores, 3.5 vs. 3. 1) and reported more pain (3.4 vs. 2.9), heavier bleeding (3.4 vs. 2.5) and bleeding of longer duration (3.3 vs. 2.6). The overwhelming majority of women in the medical and surgical abortion groups reported that they were either very or somewhat satisfied with their abortion method (81% and 82%, respectively), would recommend it to others (82% and 78%) and would choose the method again (89% and 93%). CONCLUSIONS Factors affecting the choice of abortion method appear to be numerous and complex. Providers need to be sensitive to differences in women's values and life circumstances when counseling them about an abortion method. In particular, providers should incorporate into their counseling sessions what women need to know about the characteristics of abortion methods and help women to identify what is the best option for them.
Canine Population Structure: Assessment and Impact of Intra-Breed Stratification on SNP-Based Association Studies

Background In canine genetics, the impact of population structure on whole genome association studies is typically addressed by sampling approximately equal numbers of cases and controls from dogs of a single breed, usually from the same country or geographic area. However one way to increase the power of genetic studies is to sample individuals of the same breed but from different geographic areas, with the expectation that independent meiotic events will have shortened the presumed ancestral haplotype around the mutation differently. Little is known, however, about genetic variation among dogs of the same breed collected from different geographic regions. Methodology/Principal Findings In this report, we address the magnitude and impact of genetic diversity among common breeds sampled in the U.S. and Europe. The breeds selected, including the Rottweiler, Bernese mountain dog, flat-coated retriever, and golden retriever, share susceptibility to a class of soft tissue cancers typified by malignant histiocytosis in the Bernese mountain dog. We genotyped 722 SNPs at four unlinked loci (between 95 and 271 per locus) on canine chromosome 1 (CFA1). We showed that each population is characterized by distinct genetic diversity that can be correlated with breed history. When the breed studied has a reduced intra-breed diversity, the combination of dogs from international locations does not increase the rate of false positives and potentially increases the power of association studies. However, over-sampling cases from one geographic location is more likely to lead to false positive results in breeds with significant genetic diversity. Conclusions These data provide new guidelines for association studies using purebred dogs that take into account population structure.
Molecular and cellular determinants of cell‐to‐cell transmission of HCV in vitro

It was reported previously that HCV can be transmitted from persistently infected human bone‐marrow‐derived B‐lymphoblastoid cells (TO.FEHCV) to human hepatoma cells by cell‐to‐cell contact. The present study confirms and characterize further such type of HCV infection in vitro. TO.FEHCV cells were co‐cultured with 2.2. 15 hepatoma cells, that are not susceptible to cell‐free infection by sera containing HCV of 1b genotype. By this co‐cultivation system it was demonstrated that HCV transmission to recipient cells requires de novo virus RNA replication. Several factors may favor HCV‐transmission, evidence is provided that TO.FEHCV cells were able to select HCV‐quasispecies. 5′‐UTR and core sequence analysis revealed differences in the HCV‐quasispecies composition in serum inoculum and in infected TO.FE B‐cells at 4 months post‐inoculation. It is considered that the latter may be more successful in replicating HCV in vitro and used to express surface molecules which may be involved in cell‐to‐cell contact. In TO.FEHCV cells replicate distinct, or few close related, HCV‐variants correlated with those of serum inoculum. Comparative analysis of tetraspans and integrins expression undertaken by cytofluorimetry displayed higher level of expression for TO.FE cells in comparison to other human bone‐marrow‐derived B‐cell lines. Overall, the observed persistent in vitro HCV replication is mediated by a continuous cell‐to‐cell reinfection that may be favored by selection of viral variants and expression of molecules involved in cell adhesion. These observations may provide an explanation for the establishment of HCV infection, the occurrence of chronic infection and HCV‐related lymphoproliferative diseases. J. Med. Virol. 79:1491–1499, 2007. © Wiley‐Liss, Inc.
Characteristics of a Microcystin-Degrading Bacterium under Alkaline Environmental Conditions

The pH of the water associated with toxic blooms of cyanobacteria is typically in the alkaline range; however, previously only microcystin-degrading bacteria growing in neutral pH conditions have been isolated. Therefore, we sought to isolate and characterize an alkali-tolerant microcystin-degrading bacterium from a water bloom using microcystin-LR. Analysis of the 16S rRNA gene sequence revealed that the isolated bacterium belonged to the genus Sphingopyxis, and the strain was named C-1. Sphingopyxis sp. C-1 can grow; at pH 11.0; however, the optimum pH for growth was pH 7.0. The microcystin degradation activity of the bacterium was the greatest between pH 6.52 and pH 8.45 but was also detected at pH 10.0. The mlrA homolog encoding the microcystin-degrading enzyme in the C-1 strain was conserved. We concluded that alkali-tolerant microcystin-degrading bacterium played a key role in triggering the rapid degradation of microcystin, leading to the disappearance of toxic water blooms in aquatic environments.
Psychometric properties of the Spanish version of the Health-Promoting Lifestyle Profile II.

The Health-Promoting Lifestyle Profile II (HPLPII) has been psychometrically validated across several linguistic and cultural groups; however the Spanish version has not been psychometrically tested for the Spanish population. The purpose of this research was to evaluate the reliability and factor structure of the Spanish version of the HPLPII for Spanish people. Principal component analysis (PCA) revealed that a six-component model for 44 items accounted for 40% of the variance, and the scale had an internal consistency of . 87. Confirmatory factor analysis demonstrated that a better fit of the six-component structure emerged from the PCA than from the model proposed in the original version of the HPLPII, suggesting that the health-promoting lifestyle might be sensitive to context and culture.
Variability of circadian blood pressure profile during 24-hour ambulatory blood pressure monitoring in hypertensive patients.

BACKGROUND Evaluation of circadian blood pressure (BP) profile is an important element of ambulatory BP monitoring (ABPM). Abnormal nocturnal fall in BP is more common in patients with secondary causes of hypertension and in the elderly. Cardiovascular risk is substantially increased in these patients. AIM Analysis of circadian BP profile in a population of treated hypertensives and identification of factors affecting variability of nocturnal fall in BP. METHODS 24-h ABPM was performed in hypertensive patients. Based on nocturnal fall pattern, four subgroups were identified:dippers, non-dippers, extreme dippers, and risers. Comorbidities were assessed, and data obtained in all groups were compared with the dipper profile group. RESULTS We analysed 161 patients (86 men, 53.4%). A dipper profile was noted in 44.7% of patients. Abnormal circadian BP profile was observed in 55.3% of patients, including a non-dipper profile in 21.1% of patients, an extreme dipper profilein 32.3% of patients, and a riser profile in 1.9% of patients. No significant differences in the rates of dyslipidaemia, previous myocardial infarction, previous stroke, and coronary artery disease were seen between the groups. The whole study population was also characterised by similar rates of excessive body weight and abdominal obesity. CONCLUSIONS An abnormal circadian BP profile was found in over 50% of hypertensive patients. A negative correlation was found between nocturnal BP fall and the patient age. No differences were found between groups with different circadian BP pattern regarding duration of hypertension and the presence of dyslipidaemia, obesity, diabetes, or coronary artery disease.
Dual-edge triggered static pulsed flip-flops

Two simple structures of low-power dual-edge triggered static pulsed flip-flops (DSPFF) are presented in this paper. They are composed of a dual-edge pulse generator and a static flip-flop with equal toggling delays. The static feature of DSPFF avoids unnecessary internal node transitions to reduce power consumption. Simple structure of pulse generator with double-edge triggering is proposed that results in low power dissipation in clock distribution networks. Power consumption of the DSPFF is observed to be the lowest among all high-performance flip-flops and latches. HSPICE simulation results at a frequency of 400 MHz show that the proposed DSPFF exhibits more than 24% PDP reduction compared to the hybrid-latch flip-flop (HLFF) and more than 14% PDP reduction compared to conditional-capture flip-flop (CCFF). The proposed DSPFF shows 64% power reduction in comparison to the HLFF and 59% power reduction in comparison to CCFF in practical circuits.