Miracle-dz/UniFAR-FTUs huggingface dataset:
Biomechanical changes in the sclera of monkey eyes exposed to chronic IOP elevations.

PURPOSE To characterize scleral biomechanics in both eyes of eight monkeys in which chronic intraocular pressure (IOP) elevation was induced in one eye. METHODS Each posterior sclera was mounted on a pressurization apparatus, IOP was elevated from 5 to 45 mm Hg while the 3D displacements of the scleral surface were measured by speckle interferometry. Finite element (FE) models of each scleral shell were constructed that incorporated stretch-induced stiffening and multidirectionality of the collagen fibers. FE model predictions were then iteratively matched to experimental displacements to extract unique sets of scleral biomechanical properties. RESULTS For all eyes, the posterior sclera exhibited inhomogeneous, anisotropic, nonlinear biomechanical behavior. Biomechanical changes caused by chronic IOP elevation were complex and specific to each subject. Specifically: (1) Glaucomatous eyes in which the contralateral normal eyes displayed large modulus or thickness were less prone to biomechanical changes; (2) glaucomatous scleral modulus associated with an IOP of 10 mm Hg decreased (when compared with that of the contralateral normal) after minimal chronic IOP elevation; (3) glaucomatous scleral modulus associated with IOPs of 30 and 45 mm Hg increased (when compared with that of the contralateral normal) after moderate IOP elevation; and (4) FE-based estimates of collagen fiber orientation demonstrated no change in the glaucomatous eyes. CONCLUSIONS Significant stiffening of the sclera follows exposure to moderate IOP elevations in most eyes. Scleral hypercompliance may precede stiffening or be a unique response to minimal chronic IOP elevation in some eyes. These biomechanical changes are likely to be the result of scleral extracellular matrix remodeling.
Sexual orientation topics in elementary teacher preparation programs in the USA

This investigation is a descriptive study documenting the inclusion of sexual orientation (gay and lesbian) topics in a sample of 65 public university elementary teacher preparation programs across the USA (representing the preparation of 14,000–19,000 new teachers annually). Findings indicate that only 55.6% of programs address sexual orientation topics within official program curriculum. It was also found that sexual orientation topics are largely isolated within educational foundation courses, receiving very little attention as pre‐service teachers get closer to practica and professional practice. The findings also report on the various challenges to addressing sexual orientation as indicated by program coordinators and the primary reasons given by the 44.4% of programs in the study that don’t address sexual orientation as a form of diversity within official curriculum. Conclusions suggest that elementary teacher programs may work to sustain homophobic and heterosexist school cultures through the omission of sexual orientation topics, despite the apparent commitment of the field to prepare teachers for diverse schools and communities.
Medically important arboviruses of the United States and Canada

Of more than 500 arboviruses recognized worldwide, 5 were first isolated in Canada and 58 were first isolated in the United States. Six of these viruses are human pathogens: western equine encephalitis (WEE) and eastern equine encephalitis (EEE) viruses (family Togaviridae, genus Alphavirus), St. Louis encephalitis (SLE) and Powassan (POW) viruses (Flaviviridae, Flavivirus), LaCrosse (LAC) virus (Bunyaviridae, Bunyavirus), and Colorado tick fever (CTF) virus (Reoviridae, Coltivirus). Their scientific histories, geographic distributions, virology, epidemiology, vectors, vertebrate hosts, transmission, pathogenesis, clinical and differential diagnoses, control, treatment, and laboratory diagnosis are reviewed. In addition, mention is made of the Venezuelan equine encephalitis (VEE) complex viruses (family Togaviridae, genus Alphavirus), which periodically cause human and equine disease in North America. WEE, EEE, and SLE viruses are transmitted by mosquitoes between birds; POW and CTF viruses, between wild mammals by ticks; LAC virus, between small mammals by mosquitoes; and VEE viruses, between small or large mammals by mosquitoes. Human infections are tangential to the natural cycle. Such infections range from rare to focal but are relatively frequent where they occur. Epidemics of WEE, EEE, VEE, and SLE viruses have been recorded at periodic intervals, but prevalence of infections with LAC and CTF viruses typically are constant, related to the degree of exposure to infected vectors. Infections with POW virus appear to be rare. Adequate diagnostic tools are available, but treatment is mainly supportive, and greater efforts at educating the public and the medical community are suggested if infections are to be prevented.
Acoustic chiasm V: Inhibition and excitation in the ipsilateral and contralateral projections of LSO

When this series of experiments was begun in 1984, the activity of each lateral superior olive (LSO) in the mammalian hindbrain was known to encode the hemifield of acoustic space containing a sound source. However, the almost random bilaterality of its ascending projections seemed to jumble that identification before reaching the midbrain. At the same time, electrophysiological studies of LSO and its efferent target in the inferior colliculus, along with the strictly contralateral deficits in sound localization resulting from unilateral lesions above the level of the superior olives, indicated that hemifield allegiance was largely maintained (though reversed) at the midbrain.
Intellectual Capitals' Impact on Participants' Reshare Knowledge Intention in Virtual Communities

In this study, we treat the virtual community (VC) as one type of non-profitable organization and further explore its intellectual capital which help a VC attract more participants to generating better interaction in compare with other homogeneous VCs did. Integrating expectation confirmation theory (ECT) with capital constructs derived from intellectual capitals, explain the underlying motivations of members' knowledge resharing. We conducted a three month survey by posting a 'call for participate' in JavaWorld@TW, one of the representative professional communities in Taiwan, 288 usable responses were collected from members. Using Partial Least Square(PLS) regression to test the conceptual model and corresponding hypotheses, the findings show that relation assets, satisfaction, perception of usefulness toward a community's assets have positive impact on members' intention to continue sharing knowledge. Human, structural, and instructional assets are significantly influencing members' satisfaction and perception of usefulness. Implications are proposed in the final section.
Technical Note - Capacity Allocation Under Retail Competition: Uniform and Competitive Allocations

When retailers' orders exceed the supplier's available capacity, the supplier allocates his capacity according to some allocation rule. When retailers are local monopolists, uniform allocation eliminates the “gaming effect” so that each retailer orders her ideal allocation. However, when two retailers engage in Cournot competition under complete information, a recent study has shown that uniform allocation fails to eliminate the gaming effect so that some retailer may inflate her order strategically. By examining a more general situation in which two or more retailers engage in Cournot competition under complete information, we establish exact conditions under which uniform allocation fails to eliminate the gaming effect. These exact conditions enable us to construct a new rule called competitive allocation that can eliminate the gaming effect. Without inflated orders from the retailers, the supplier's profit could be lower under competitive allocation than under uniform allocation when certain restrictive conditions hold. In contrast, competitive allocation generates higher average profits for the retailers and for the supply chain; hence, it reduces the inefficiency of the decentralized supply chain.
Impact of Fishmeal Replacement in Diets for Gilthead Sea Bream (Sparus aurata) on the Gastrointestinal Microbiota Determined by Pyrosequencing the 16S rRNA Gene

Recent studies have demonstrated the impact of diet on microbiota composition, but the essential need for the optimization of production rates and costs forces farms and aquaculture production to carry out continuous dietary tests. In order to understand the effect of total fishmeal replacement by vegetable-based feed in the sea bream (Sparus aurata), the microbial composition of the stomach, foregut, midgut and hindgut was analysed using high-throughput 16S rDNA sequencing, also considering parameters of growth, survival and nutrient utilisation indices.A total of 91,539 16S rRNA filtered-sequences were analysed, with an average number of 3661.56 taxonomically assigned, high-quality sequences per sample. The dominant phyla throughout the whole gastrointestinal tract were Actinobacteria, Protebacteria and Firmicutes. A lower diversity in the stomach in comparison to the other intestinal sections was observed. The microbial composition of the Recirculating Aquaculture System was totally different to that of the sea bream gastrointestinal tract. Total fishmeal replacement had an important impact on microbial profiles but not on diversity. Streptococcus (p-value: 0.043) and Photobacterium (p-value: 0.025) were highly represented in fish fed with fishmeal and vegetable-meal diets, respectively. In the stomach samples with the vegetable diet, reads of chloroplasts and mitochondria from vegetable dietary ingredients were rather abundant. Principal Coordinate Analysis showed a clear differentiation between diets in the microbiota present in the gut, supporting the presence of specific bacterial consortia associated with the diet.Although differences in growth and nutritive parameters were not observed, a negative effect of the vegetable diet on the survival rate was determined. Further studies are required to shed more light on the relationship between the immune system and sea bream gastrointestinal tract microbiota and should consider the modulation of the microbiota to improve the survival rate and nutritive efficacy when using plant-based diets.
Genotypic Differences in Phosphorus Efficiency and the Performance of Physiological Characteristics in Response to Low Phosphorus Stress of Soybean in Southwest of China

Southwest of China is one of the major soybean (Glycine max L.) production regions in China with low availability of soil phosphorus (P). Whereas little information is available on P-efficient soybean genotypes in this region, even though using P-efficient soybean genotypes is a sustainable P management strategy for enhancing yield and P use efficiency. To assess the genetic variation on P use efficiency, 274 soybean genotypes were employed to compare the yields and P acquisition potentials in the field. Additionally, 10 representational genotypes (5 P-efficient genotypes and 5 P-inefficient genotypes) were grown in hydroponic media containing low P treatment (0.05 mM L−1) and high P treatment (0.25 mM L−1) to further investigate P assimilation characteristics and the related mechanisms of P-efficient soybean genotypes. In the field trial, the models described the relationships between yield and seed P concentration (R2 = 0.85), shoot P accumulation (R2 = 0.84), HI (R2 = 0.82) well. The yield, seed P concentration and shoot P accumulation ranged from 5.5 to 36.0 g plant−1, from 0.045 to 0.93% and from 0.065 to 0.278 mg plant−1, respectively. In the hydroponic trial, P-efficient genotypes under low P treatment showed significantly better plant growth, P accumulation and root: shoot ratio than P-inefficient genotypes. Simultaneously, total root length, specific root length, root surface area and root volume of P-efficient were significantly greater than P-inefficient under low P treatment. Higher rate of organic acid exudation and acid phosphatase activities was observed in the P-efficient soybean genotypes under low P condition when compared to the P-inefficient soybean genotypes. It indicated that significant genetic variation for P use efficiency existed in this region, and the P-efficient soybean genotypes, especially E311 and E141, demonstrated great tolerance to P deficiency, which could be potential materials using in improving production and P use efficiency in low availability of soil P region.
Comparison of Murine Cervicovaginal Infection by Chlamydial Strains: Identification of Extrusions Shed In vivo

Chlamydia trachomatis is the leading cause of bacterial sexually transmitted infections (STIs) and preventable blindness. Untreated, asymptomatic infection as well as frequent re-infection are common and may drive pelvic inflammatory disease, ectopic pregnancy, and infertility. In vivo models of chlamydial infection continue to be instrumental in progress toward a vaccine and further elucidating the pathogenesis of this intracellular bacterium, however significant gaps in our understanding remain. Chlamydial host cell exit occurs via two mechanisms, lysis and extrusion, although the latter has yet to be reported in vivo and its biological role is unclear. The objective of this study was to investigate whether chlamydial extrusions are shed in vivo following infection with multiple strains of Chlamydia. We utilized an established C3H/HeJ murine cervicovaginal infection model with C. trachomatis serovars D and L2 and the Chlamydia muridarum strain MoPn to monitor the (i) time course of infection and mode of host cell exit, (ii) mucosal and systemic immune response to infection, and (iii) gross and histopathology following clearance of active infection. The key finding herein is the first identification of chlamydial extrusions shed from host cells in an in vivo model. Extrusions, a recently appreciated mode of host cell exit and potential means of dissemination, had been previously observed solely in vitro. The results of this study demonstrate that chlamydial extrusions exist in vivo and thus warrant further investigation to determine their role in chlamydial pathogenesis.
THE EFFECTS OF EMPLOYER-SPONSORED CHILD CARE ON EMPLOYEE ABSENTEEISM, TURNOVER, PRODUCTIVITY, RECRUITMENT OR JOB SATISFACTION: WHAT IS CLAIMED AND WHAT IS KNOWN

An evaluation is made of the evidence supporting claims that employer-sponsored child care programs improve employee work behaviors and attitudes. Explanation of the logic behind expectations for success, description of testimony for employer-sponsored child care and critiques of empirical studies are presented. Well planned evaluations with proper controls appear to be absent. Documentation was equivocal on whether women workers of child-bearing age were absent from work more than men or quit more often than men. Even if greater absences among women was assumed, it was suggested that this could be due to factors other than child care - such as lower attachment to work or need for wages in two-income households, or poorly paid and low prestige jobs. Despite enthusiasm by some chief executive officers, public relations officials and child care advocates, assertions that employer-sponsored child care reduces workers' absenteeism or tardiness, or that it increases workers' productivity or job satisfaction are not supported by credible research.
Is evaluative conditioning really resistant to extinction? Evidence for changes in evaluative judgements without changes in evaluative representations

Evaluative conditioning (EC) is defined as the change in the evaluation of a conditioned stimulus (CS) due to its pairing with a positive or negative unconditioned stimulus (US). Although several individual studies suggest that EC is unaffected by unreinforced presentations of the CS without the US, a recent meta-analysis indicates that EC effects are less pronounced for post-extinction measurements than post-acquisition measurements. The disparity in research findings suggests that extinction of EC may depend on yet unidentified conditions. In an attempt to uncover these conditions, three experiments (N = 784) investigated the influence of unreinforced post-acquisition CS presentations on EC effects resulting from simultaneous versus sequential pairings and pairings with single versus multiple USs. For all four types of CS–US pairings, EC effects on self-reported evaluations were reduced by unreinforced CS presentations, but only when the CSs had been rated after the initial presentation of CS–US pairings. EC effects on an evaluative priming measure remained unaffected by unreinforced CS presentations regardless of whether the CSs had been rated after acquisition. The results suggest that reduced EC effects resulting from unreinforced CS presentations are due to judgement-related processes during the verbal expression of CS evaluations rather than genuine changes in the underlying evaluative representations.
The Myth of Research‐based Practice: The Critical Case of Educational Inquiry

Educational research in Britain has been subject to substantial government intervention in recent years. The rationale for this has been the demands made by a model of evidence‐based policymaking and practice that carries implications for other fields of social research as well. In this paper, the growing influence of this model is sketched, and it is argued that it relies on some very questionable assumptions about what research can offer policymakers and practitioners. It is concluded that the consequences of enforcing this model are likely to be negative for both sides, but especially for research.
Educational reform and teacher education in Vietnam

This paper examines the current state and a challenge faced by teachers and teacher education in Vietnam, and analyzes international aid projects providing support to teacher education there. It is necessary to grasp changes in teacher education in Vietnam in the context of the current comprehensive reform of education, which has been greatly influenced by world trends. In Vietnam today, improving the quality of basic education has been given a high priority, in line with the global movement for Education for All (EFA). The main task for improving the quality of education in Vietnam is the effective implementation of the new curriculum adopted in 2002. Teacher education is the key to completing this task. It is important for teachers to learn new methods of instruction, and teacher education needs to be strengthened to allow them to acquire these new methods. A great deal of international assistance is provided for the promotion of this type of teacher education. Projects in this area are provided by the World Bank, Belgium, and Japan. This paper analyzes these projects, and examines the challenges facing international assistance for teacher education.
The “Crisis of Pity” and the Radicalization of Solidarity: Toward Critical Pedagogies of Compassion

This article joins discussions concerning education as a means of cultivating compassion and pays explicit attention to the emotional complexities of teaching for/with compassion to help students become active and critical compassionate citizens. After reviewing the emotional aspects that establish feelings of pity and a sentimental relationship between the student as spectator and the ‘other’ who suffers, the article suggests that a politics of compassion is both necessary and valuable, albeit situated in practices that attend to the needs of vulnerable people and address structural inequalities. The article explores the conditions within which compassion in the classroom can be translated into protest at injustice or transmuted into action that radicalizes solidarity. For this purpose, the author proposes what he calls critical pedagogies of compassion, that is, critical pedagogies that interrogate the trappings of narratives of pity and seek to make a concrete difference in sufferers’ lives. This is not a proposition for a new form of critical pedagogy, but rather a call to recognize in existing critical pedagogies the need to explicitly interrogate pity and cultivate critical compassion.
Psychophysical conditions and hormonal secretion in nurses on a rapidly rotating shift schedule and exposed to bright light during night work

Abstract The psychophysical conditions of 15 young female nurses, working in a rapidly-rotating shift system (2-2-2-2), modified according to some psychophysiological criteria, and exposed to short period (4 × 20 min) of bright light (2350 Lux) during their night duty, were studied in order to evaluate their adaptation to night work and to test a possible positive effect on it of bright light. Subjective evaluations of work load and psychophysical conditions, performance measures, hormonal excretion (cortisol, 6-sulphatoxymelatonin and catecholamines), oral temperature and activity-sleep logs were taken during the shiftwork cycle, comprising one morning, one afternoon and two consecutive nights under normal and bright light. The results showed that this rapidly-rotating shift system had little effect upon the normal circadian rhythms of the body. Moreover, the lengthening of the night shift to 10 h can be considered to be acceptable, provided that work load is reduced and there are sufficient rest pauses .
Re‐examining the effects of psychological contract violations: unmet expectations and job dissatisfaction as mediators

This research examines whether the relationships between psychological contract violations and three types of employee behavior (intention to quit, neglect of in-role job duties, and organizational citizenship behaviors) are mediated by unmet expectations and job dissatisfaction. Using a sample of over 800 managers from a wide variety of research sites, this study tests for mediator effects using both hierarchical regression analyses and structural equation modelling. The results suggest that unmet expectations and job dissatisfaction do partially mediate such relationships. Copyright © 2000 John Wiley & Sons, Ltd.
Triadin and CLIMP-63 form a link between triads and microtubules in muscle cells

ABSTRACT In skeletal muscle, the triad is a structure comprising a transverse (T)-tubule and sarcoplasmic reticulum (SR) cisternae. Triads constitute the basis of excitation–contraction coupling as the cradle of the Ca2+ release complex. We have shown previously that triadin, a member of this complex, has shaping properties on reticulum membrane and is indirectly involved in a link between triads and microtubules. We have identified here that CLIMP-63 (also known as CKAP4), as the partner of triadin, is responsible for this association of triads and microtubules. Triadin and CLIMP-63 interact through their respective luminal domains and the shaping properties of triadin depend on the capacity of CLIMP-63 to bind microtubules with its cytosolic portion. In skeletal muscle, CLIMP-63 is localized in the SR, including triads, and is associated with the Ca2+ release complex through its interaction with triadin. Knockout of triadin in muscles results in the delocalization of CLIMP-63 from triads, its dissociation from the Ca2+ release complex and a disorganization of the microtubule network. Our results suggest that the association of triadin and CLIMP-63 could be involved in the shaping of SR terminal cisternae and in the guidance of microtubules close to the triads. Summary: CLIMP-63 is associated with the Ca2+ release complex of skeletal muscles through its interaction with triadin, and is involved in the shaping of triads and in the guidance of microtubules.