Miracle-dz/UniFAR-FTUs huggingface dataset:
Pregnancy outcome and prepregnancy body mass index in 2459 glucose-tolerant Danish women.

OBJECTIVE This study was undertaken to investigate the relationship between pregnancy outcome and prepregnancy overweight or obesity in women with a normal glucose tolerance test. STUDY DESIGN A historical cohort study of 2459 pregnant women systematically examined for gestational diabetes was performed. Information of oral glucose tolerance test results and clinical outcome were collected from medical records. RESULTS The risk of hypertensive complications, cesarean section, induction of labor and macrosomia was significantly increased in both overweight women (body mass index [BMI] 25.0-29.9 kg/m(2)) and obese women (BMI >or= 30.0 kg/m(2)) compared with women who were of normal weight (BMI 18.5-24.9 kg/m(2)). The frequencies of shoulder dystocia, preterm delivery, and infant morbidity other than macrosomia were not significantly associated with maternal BMI. CONCLUSION Prepregnancy overweight and obesity is associated with adverse pregnancy outcome in glucose-tolerant women.
Large loop conformation sampling using the activation relaxation technique, ART‐nouveau method

We present an adaptation of the ART‐nouveau energy surface sampling method to the problem of loop structure prediction. This method, previously used to study protein folding pathways and peptide aggregation, is well suited to the problem of sampling the conformation space of large loops by targeting probable folding pathways instead of sampling exhaustively that space. The number of sampled conformations needed by ART nouveau to find the global energy minimum for a loop was found to scale linearly with the sequence length of the loop for loops between 8 and about 20 amino acids. Considering the linear scaling dependence of the computation cost on the loop sequence length for sampling new conformations, we estimate the total computational cost of sampling larger loops to scale quadratically compared to the exponential scaling of exhaustive search methods. Proteins 2012; © 2012 Wiley Periodicals, Inc.
Effects of caffeine on time to exhaustion in exercise performed below and above the anaerobic threshold.

Controversy still exists concerning the potential ergogenic benefit of caffeine (CAF) for exercise performance. The purpose of this study was to compare the effects of CAF ingestion on endurance performance during exercise on a bicycle ergometer at two different intensities, i.e., approximately 10% below and 10% above the anaerobic threshold (AT). Eight untrained males, non-regular consumers of CAF, participated in this study. AT, defined as the intensity (watts) corresponding to a lactate concentration of 4 mM, was determined during an incremental exercise test from rest to exhaustion on an electrically braked cycle ergometer. On the basis of these measurements, the subjects were asked to cycle until exhaustion at two different intensities, i.e., approximately 10% below and 10% above AT. Each intensity was performed twice in a double-blind randomized order by ingesting either CAF (5 mg/kg) or a placebo (PLA) 60 min prior to the test. Venous blood was analyzed for free fatty acid, glucose, and lactate, before, during, and immediately after exercise. Rating of perceived exertion and time to exhaustion were also measured during each trial. There were no differences in free fatty acids or lactate levels between CAF and PLA during and immediately after exercise for either intensity. Immediately after exercise glucose increased in the CAF trial at both intensities. Rating of perceived exertion was significantly lower (CAF = 14.1 +/- 2.5 vs PLA = 16.6 +/- 2.4) and time to exhaustion was significantly higher (CAF = 46.54 +/- 8.05) min vs PLA = 32.42 +/- 14.81 min) during exercise below AT with CAF. However, there was no effect of CAF treatment on rating of perceived exertion (CAF = 18.0 +/- 2.7 vs PLA = 17.6 +/- 2.3) and time to exhaustion (CAF = 18.45 +/- 7.28 min vs PLA = 19.17 +/- 4.37 min) during exercise above AT. We conclude that in untrained subjects caffeine can improve endurance performance during prolonged exercise performed below AT and that the decrease of perceived exertion can be involved in this process.
Teacher, Researcher and … Policy Actor? Social Work Academics’ Involvement in Social Policy

This cross-sectional quantitative study expands the knowledge on the level of involvement of social work academics (SWAs) in social policy formulation processes, and the factors associated with this. SWAs are an interesting case for exploring the academia–policy nexus because they are affiliated with a profession in which the discourse regards social policy as a target of intervention. The study took place in Israel, where social work is strongly embedded in academia and enjoys relatively high professional status. The study drew upon a sample, which consisted of 57 per cent of all SWAs in Israel, and employed questionnaires developed specifically for the study. The findings show that the highest levels of involvement were in activities characterized by more active, public sphere routes of influence within the policy arena that were undertaken in conjunction with traditional social work partners. Social work scholars engaged in these activities more during the initial stages of the policy process. These forms of policy involvement reflect the dual impact of academia and the social work profession upon SWAs. Associated with level of involvement were individual factors, which included academic rank, perception of the social role of academia, perceived individual policy role, and perceived policy competencies. By contrast, factors linked to institutional support for policy engagement were not found to be associated with policy involvement.
Low Enzymatic Activity Haplotypes of the Human Catechol-O-Methyltransferase Gene: Enrichment for Marker SNPs

Catechol-O-methyltransferase (COMT) is an enzyme that plays a key role in the modulation of catechol-dependent functions such as cognition, cardiovascular function, and pain processing. Three common haplotypes of the human COMT gene, divergent in two synonymous and one nonsynonymous (val 158 met) position, designated as low (LPS), average (APS), and high pain sensitive (HPS), are associated with experimental pain sensitivity and risk of developing chronic musculoskeletal pain conditions. APS and HPS haplotypes produce significant functional effects, coding for 3- and 20-fold reductions in COMT enzymatic activity, respectively. In the present study, we investigated whether additional minor single nucleotide polymorphisms (SNPs), accruing in 1 to 5% of the population, situated in the COMT transcript region contribute to haplotype-dependent enzymatic activity. Computer analysis of COMT ESTs showed that one synonymous minor SNP (rs769224) is linked to the APS haplotype and three minor SNPs (two synonymous: rs6267, rs740602 and one nonsynonymous: rs8192488) are linked to the HPS haplotype. Results from in silico and in vitro experiments revealed that inclusion of allelic variants of these minor SNPs in APS or HPS haplotypes did not modify COMT function at the level of mRNA folding, RNA transcription, protein translation, or enzymatic activity. These data suggest that neutral variants are carried with APS and HPS haplotypes, while the high activity LPS haplotype displays less linked variation. Thus, both minor synonymous and nonsynonymous SNPs in the coding region are markers of functional APS and HPS haplotypes rather than independent contributors to COMT activity.
Concealed carry bans and the American college campus: a law, social sciences, and policy perspective

Abstract Should individuals on American college campuses be permitted to carry concealed weapons? This issue positions second Amendment liberty guarantees against personal safety concerns and learning environment interests. Current policy prescription has yet to appropriately balance these competing demands. Accordingly, this article reviews and comments on three key dimensions of the concealed carry ban controversy. This includes a presentation of the governing case law, a recounting of the relevant social science findings, and a discussion of the societal forces and human dynamics that both inform and influence this public policy debate. We argue that these forces and dynamics constitute cultural impediments to achieving meaningful consensus-building legislation. The manuscript concludes by proposing several justice-based reformist directions with relevancies for academic researchers, political officials, and policy-makers.
Loss of p27 nuclear expression in a prognostically favorable subset of well-differentiated pancreatic endocrine neoplasms.

Decreased expression of p27 occurs in aggressive colon, breast, and prostate neoplasms; p27 loss often correlates with worsened prognosis. Paradoxical overexpression has been described in benign and malignant pancreatic endocrine neoplasms (PENs). To investigate prognostic usefulness of p27 expression in PENs, we immunolabeled 42 primary PENs, with or without metastases, for p27 and separated lesions using a nuclear labeling index (NLI) of 10%. Of the 42 lesions, 26 demonstrated a 10% or higher NLI and 16 an NLI less than 10%. Comparison of lymph node status revealed that 50% of primary PENs with a 10% or higher NLI (13/26) demonstrated lymph node metastases, whereas only 6% of lesions with an NLI of less than 10% (1/16) demonstrated lymph node metastases (P = .0067). We next examined 11 liver and 7 lymph node metastases for p27 immunolabeling to determine whether p27 also is paradoxically retained in lesions that have metastasized. All 18 lesions demonstrated an NLI of 10% or higher for p27. Expression of p27 protein therefore appears to be lost in a subset of well-differentiated PENs with indolent features but paradoxically retained in PENs associated with metastatic disease.
Addressing a Question Answering Challenge by Combining Statistical Methods with Inductive Rule Learning and Reasoning

A group of researchers from Facebook has recently proposed a set of 20 question-answering tasks (Facebook's bAbl dataset) as a challenge for the natural language understanding ability of an intelligent agent. These tasks are designed to measure various skills of an agent, such as: fact based question-answering, simple induction, the ability to find paths, co-reference resolution and many more. Their goal is to aid in the development of systems that can learn to solve such tasks and to allow a proper evaluation of such systems. They show existing systems cannot fully solve many of those toy tasks. In this work, we present a system that excels at all the tasks except one. The proposed model of the agent uses the Answer Set Programming (ASP) language as the primary knowledge representation and reasoning language along with the standard statistical Natural Language Processing (NLP) models. Given a training dataset containing a set of narrations, questions and their answers, the agent jointly uses a translation system, an Inductive Logic Programming algorithm and Statistical NLP methods to learn the knowledge needed to answer similar questions. Our results demonstrate that the introduction of a reasoning module significantly improves the performance of an intelligent agent.
Stabilized Sparse Online Learning for Sparse Data

Stochastic gradient descent (SGD) is commonly used for optimization in large-scale machine learning problems. Langford et al. (2009) introduce a sparse online learning method to induce sparsity via truncated gradient. With high-dimensional sparse data, however, the method suffers from slow convergence and high variance due to the heterogeneity in feature sparsity. To mitigate this issue, we introduce a stabilized truncated stochastic gradient descent algorithm. We employ a soft-thresholding scheme on the weight vector where the imposed shrinkage is adaptive to the amount of information available in each feature. The variability in the resulted sparse weight vector is further controlled by stability selection integrated with the informative truncation. To facilitate better convergence, we adopt an annealing strategy on the truncation rate, which leads to a balanced trade-off between exploration and exploitation in learning a sparse weight vector. Numerical experiments show that our algorithm compares favorably with the original algorithm in terms of prediction accuracy, achieved sparsity and stability.
Compartment-specific distribution of human intestinal innate lymphoid cells is altered in HIV patients under effective therapy

Innate lymphocyte cells (ILCs), a novel family of innate immune cells are considered to function as key orchestrators of immune defences at mucosal surfaces and to be crucial for maintaining an intact intestinal barrier. Accordingly, first data suggest depletion of ILCs to be involved in human immunodeficiency virus (HIV)-associated damage of the intestinal mucosa and subsequent microbial translocation. However, although ILCs are preferentially localized at mucosal surfaces, only little is known regarding distribution and function of ILCs in the human gastrointestinal tract. Here, we show that in HIV(-) individuals composition and functional capacity of intestinal ILCs is compartment-specific with group 1 ILCs representing the major fraction in the upper gastrointestinal (GI) tract, whereas ILC3 are the predominant population in ileum and colon, respectively. In addition, we present first data indicating that local cytokine concentrations, especially that of IL-7, might modulate composition of gut ILCs. Distribution of intestinal ILCs was significantly altered in HIV patients, who displayed decreased frequency of total ILCs in ileum and colon owing to reduced numbers of both CD127(+)ILC1 and ILC3. Of note, frequency of colonic ILC3 was inversely correlated with serum levels of I-FABP and sCD14, surrogate markers for loss of gut barrier integrity and microbial translocation, respectively. Both expression of the IL-7 receptor CD127 on ILCs as well as mucosal IL-7 mRNA levels were decreased in HIV(+) patients, especially in those parts of the GI tract with reduced ILC frequencies, suggesting that impaired IL-7 responses of ILCs might contribute to incomplete reconstitution of ILCs under effective anti-retroviral therapy. This is the first report comparing distribution and function of ILCs along the intestinal mucosa of the entire human gastrointestinal tract in HIV(+) and HIV(-) individuals.
AIDS Knowledge and Measurement Considerations with Unacculturated Latinos

Likert-type scales are frequently used in research with different ethnic groups. Differences in cultural response styles and understanding of the scale have long been noted but rarely explored in research. This article presents the authors’ experiences in using a Likert-type questionnaire to measure AIDS knowledge among recently arrived Mexican immigrants in the southeastern United States. The questionnaire findings were compared to a qualitative assessment using vignettes to ascertain knowledge of AIDS casual transmission. It was found that a lack of association existed between the respondents’ answers to the quantitative AIDS Likert-type scale and the qualitative vignettes. In-depth interviews to understand the problems respondents were having with the scaling (linguistics, format, and wording of the AIDS questionnaire) supported the findings of a lack of association between the two methods of knowledge assessment. The findings suggest that the Likert-type format is confusing for, and does not accurately reflect knowledge in, recently arrived Mexican immigrants.
London dispersion in molecular chemistry--reconsidering steric effects.

London dispersion, which constitutes the attractive part of the famous van der Waals potential, has long been underappreciated in molecular chemistry as an important element of structural stability, and thus affects chemical reactivity and catalysis. This negligence is due to the common notion that dispersion is weak, which is only true for one pair of interacting atoms. For increasingly larger structures, the overall dispersion contribution grows rapidly and can amount to tens of kcal mol(-1) . This Review collects and emphasizes the importance of inter- and intramolecular dispersion for molecules consisting mostly of first row atoms. The synergy of experiment and theory has now reached a stage where dispersion effects can be examined in fine detail. This forces us to reconsider our perception of steric hindrance and stereoelectronic effects. The quantitation of dispersion energy donors will improve our ability to design sophisticated molecular structures and much better catalysts.
Roles of the reproductive tract in modifications of the sperm membrane surface

Successful fertilization requires viable and functional spermatozoa to recognize and fuse with the oocyte. In most mammalian species, mature spermatozoa are not capable of fertilizing the oocytes immediately after ejaculation. However, unlike somatic cells, spermatozoa, after leaving the testis, are transcriptionally and translationally silent; therefore, upon completion of spermiogenesis, spermatozoa carry only a minimal amount of essential proteins on their membranes as well as within their restricted volume of cytoplasm. To develop into a fully functional and competent sperm that is capable of successful fertilization, modifications of the sperm membrane surface during its transit in the reproductive tracts is critical. These post-spermatogenesis modifications advance the maturation of epididymal spermatozoa. In addition, components secreted into the lumen of the reproductive tracts that are later added onto the sperm membrane surface also regulate (inhibit or activate) the functions of the spermatozoa. This acquisition of additional proteins from the reproductive tracts may compensate for the inactivity of morphologically mature spermatozoa. In this review, we discuss the contributions of the male and female genital tracts to modifications of the sperm membrane surface at different stages of fertilization.
Reduced mortality with hospital pay for performance in England.

BACKGROUND Pay-for-performance programs are being adopted internationally despite little evidence that they improve patient outcomes. In 2008, a program called Advancing Quality, based on the Hospital Quality Incentive Demonstration in the United States, was introduced in all National Health Service (NHS) hospitals in the northwest region of England (population, 6.8 million). METHODS We analyzed 30-day in-hospital mortality among 134,435 patients admitted for pneumonia, heart failure, or acute myocardial infarction to 24 hospitals covered by the pay-for-performance program. We used difference-in-differences regression analysis to compare mortality 18 months before and 18 months after the introduction of the program with mortality in two comparators: 722,139 patients admitted for the same three conditions to the 132 other hospitals in England and 241,009 patients admitted for six other conditions to both groups of hospitals. RESULTS Risk-adjusted, absolute mortality for the conditions included in the pay-for-performance program decreased significantly, with an absolute reduction of 1.3 percentage points (95% confidence interval [CI], 0.4 to 2.1; P=0.006) and a relative reduction of 6%, equivalent to 890 fewer deaths (95% CI, 260 to 1500) during the 18-month period. The largest reduction, for pneumonia, was significant (1.9 percentage points; 95% CI, 0.9 to 3.0; P<0.001), with nonsignificant reductions for acute myocardial infarction (0.6 percentage points; 95% CI, -0.4 to 1.7; P=0.23) and heart failure (0.6 percentage points; 95% CI, -0.6 to 1.8; P=0.30). CONCLUSIONS The introduction of pay for performance in all NHS hospitals in one region of England was associated with a clinically significant reduction in mortality. As compared with a similar U.S. program, the U.K. program had larger bonuses and a greater investment by hospitals in quality-improvement activities. Further research is needed on how implementation of pay-for-performance programs influences their effects. (Funded by the NHS National Institute for Health Research.).
Class Composition and Student Achievement in Elementary Schools

Principals and teachers sometimes intentionally use class formation procedures to create class compositions. This study examined the class distributional properties of 200 elementary school classes in two school districts. Fifty-six classes were combination classes—classes with students from two grade levels. The two districts differed in their policies toward gifted and talented classes and in principals’ preferences for heterogeneous student assignment. Students completed pretest measures of ability and independence and posttest measures of achievement. Hierarchical linear modeling procedures were used to estimate composition effects. The major findings were that (a) principals and teachers assigned higher ability and more independent students to combination classes; (b) these purposeful assignment procedures affected the class distributional properties and how achievement variation was allocated within and between classes; and (c) composition effects were observed for both ability and independence in the district with a commitment to gifted and talented classes, and these composition effects were strongest in combination classes. It is argued that evidence on both student assignment rules and substantive mechanisms for compositional effects are needed to properly interpret regression coefficients relating outcome to pretest in classroom studies.
how tall is a taxonomic tree? some evidence for dwarfism1

Several arguments are made in this paper: (1) Taxonomic tree models of folk classification are implicitly generative because they produce appropriate statements which are not in the description itself. (2) The generative devices sometimes postulated—namely, transitive reasoning operating on chains of directly included taxa—do not account for some evidence which another model, the direct comparison between prototypic images, does. (3) Taxonomic trees are probably not stored directly in the memory except perhaps as “dwarf” trees consisting of contrast sets and their names. (4) Routine classification behavior is not so much a matter of producing giant taxonomic trees as it is a matter of selecting, in particular socioeconomic situations, a characteristic of an organism relevant for action.
Sterile neutrino dark matter as a consequence of νMSM-induced lepton asymmetry

It has been pointed out by one of the authors (Shaposhnikov 2008 Preprint 0804.4542) that in the νMSM (Standard Model extended with three right-handed neutrinos with masses smaller than the electroweak scale), there is a corner in the parameter space where CP-violating resonant oscillations among the two heaviest right-handed neutrinos continue to operate below the freeze-out temperature of sphaleron transitions, leading to a lepton asymmetry which is considerably larger than the baryon asymmetry. Consequently, the lightest right-handed (‘sterile’) neutrinos, which may serve as dark matter, are generated through an efficient resonant mechanism proposed by Shi and Fuller (1999 Phys. Rev. Lett. 82 2832 [astro-ph/9810076]). We re-compute the dark matter relic density and non-eq uilibrium momentum distribution function in this situation with quantum field theoretic methods and, confronting the results with existing astrophysical data, derive bounds on the properties of the lightest right-handed neutrinos. Our spectra can be used as an input for structure formation simulations in warm dark matter cosmologies, for a Lyman-α analysis of the dark matter distribution on small scales, and for studying the properties of haloes of dwarf spheroidal galaxies.