Miracle-dz/UniFAR-FTUs huggingface dataset:
Chemoresistance to Concanamycin A1 in Human Oral Squamous Cell Carcinoma Is Attenuated by an HDAC Inhibitor Partly via Suppression of Bcl-2 Expression

V-ATPase is involved in the acidification of the microenvironment around/in solid tumors, such as oral squamous cell carcinoma (OSCC). V-ATPase is thought to induce tumor invasion and multi-drug resistance in several malignant tumors, and it also contributes to maintaining the intracellular pH under an acidic microenvironment by inducing proton extrusion into the extracellular medium. However, there is little information regarding the effects of V-ATPase inhibitors on OSCCs. In this study, the effects of a V-ATPase inhibitor, concanamycin A1 (CMA), on the proliferation and apoptosis of OSCC were investigated in vitro. We used four OSCC cell lines, MISK81-5, SAS, HSC-4 and SQUU-B. Acridine orange staining revealed that the red fluorescence was reduced in all of the low concentration CMA-treated OSCC cells, indicating that the acidification of vesicular organelles in the OSCCs was prevented by the treatment with low-concentration of CMA. CMA treatment induced apoptosis in MISK81-5, SAS and HSC-4 cells, but not in SQUU-B cells. The p-p38 expression was not altered in CMA-treated SQUU-B cells, but their levels were increased in the other cells. The Bax/Bcl-2 ratio in CMA-treated SQUU-B cells was dramatically decreased in comparison with that in the other cell lines treated with CMA. However, when the SQUU-B cells were treated with CMA and a histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA), the SQUU-B cells became more susceptible to the CMA-induced apoptosis. SAHA treatment led to a significantly decrease in the Bcl-2 expression in CMA-treated SQUU-B cells, resulting in a dramatically increased Bax/Bcl-2 ratio in comparison with that observed in the SQUU-B cells treated with CMA alone. These findings suggest that CMA could have an anti-tumor effect on OSCCs. In addition, combination of CMA with other agents, such as SAHA, could help improve the pro-apoptotic effects of CMA even in CMA-resistant OSCC cells.
Assessing Asset Pricing Anomalies

The optimal portfolio strategy is developed for an investor who has detected an asset pricing anomaly but is not certain that the anomaly is genuine rather than merely apparent. The analysis takes account of the fact that the parameters of both the underlying asset pricing model and the anomalous returns are estimated rather than known. The value that an investor would place on the ability to invest to exploit the apparent anomaly is also derived and illustrative calculations are presented for the Fama and French SMB and HML portfolios, whose returns are anomalous relative to the CAPM. Article published by Oxford University Press on behalf of the Society for Financial Studies in its journal, The Review of Financial Studies.
Finite frequency approaches to H∞ filtering for continuous-time state-delayed systems

This paper is concerned with the problem of H∞ filter design for linear continuous-time state-delayed systems with finite frequency specifications. The developed approaches in the paper are to design a filter guaranteeing an H∞ performance bound in a finite frequency range for delayed systems. To reduce conservatism, delay-partitioning idea is exploited to derive a new finite frequency bounded real lemma (BRL). By utilizing the generalized Kalman-Yakubovich-Popov lemma and projection lemma, the conditions on the existence of H∞ filters for different finite frequency ranges are unified in terms of solving a set of linear matrix inequalities.
Racial and Ethnic Differences in the Relationship between Birth weight and Type 2 Diabetes Mellitus in Postmenopausal Women

Objective— To examine the relationship between self-reported birth weight and the adult occurrence of type 2 diabetes mellitus in a large multi-ethnic population of women. Research Design and Methods— Baseline data from the Women's Health Initiative Observational Study [N= 75,993] was used to examine the association between participant birth weight category and prevalent type 2 diabetes. Models were adjusted for age and ethnicity. Adult BMI was investigated as a potential modifying variable. Sub-analyses were performed stratifying by race/ethnicity. Results— Reporting a birth weight of <6 lbs. (OR=1.35, 95% CI=1.21-1.50) was significantly associated with self-reported type 2 diabetes compared to women who reported their birth weight between 7 and 8 lbs. 15 oz. Stratifying by race, birth weight of <6 lbs. was associated with type 2
Closed-Loop Brain Model of Neocortical Information-Based Exchange

Here we describe an “information-based exchange” model of brain function that ascribes to neocortex, basal ganglia, and thalamus distinct network functions. The model allows us to analyze whole brain system set point measures, such as the rate and heterogeneity of transitions in striatum and neocortex, in the context of neuromodulation and other perturbations. Our closed-loop model is grounded in neuroanatomical observations, proposing a novel “Grand Loop” through neocortex, and invokes different forms of plasticity at specific tissue interfaces and their principle cell synapses to achieve these transitions. By implementing a system for maximum information-based exchange of action potentials between modeled neocortical areas, we observe changes to these measures in simulation. We hypothesize that similar dynamic set points and modulations exist in the brain's resting state activity, and that different modifications to information-based exchange may shift the risk profile of different component tissues, resulting in different neurodegenerative diseases. This model is targeted for further development using IBM's Neural Tissue Simulator, which allows scalable elaboration of networks, tissues, and their neural and synaptic components toward ever greater complexity and biological realism.
An empirical study of a wide-area distributed file system

The evolution of the Andrew File System (AFS) into a wide-area distributed file system has encouraged collaboration and information dissemination on a much broader scale than ever before. We examine AFS as a provider of wide-area file services to over 100 organizations around the world. We discuss usage characteristics of AFS derived from empirical measurements of the system. Our observations indicate that AFS provides robust and efficient data access in its current configuration, thus confirming its viability as a design point for wide-area distributed file systems.
Functionalization of Artificial Freestanding Composite Nanomembranes

Artificial nanomembranes may be defined as synthetic freestanding structures with a thickness below 100 nm and a very large aspect ratio, of at least a few orders of magnitude. Being quasi-2D, they exhibit a host of unusual properties useful for various applications in energy harvesting, sensing, optics, plasmonics, biomedicine, etc. We review the main approaches to nanomembrane functionalization through nanocompositing, which ensures performance far superior to that of simple nanomembranes. These approaches include lamination (stacking of nanometer-thin strata of different materials), introduction of nanoparticle fillers into the nanomembrane scaffold, nanomembrane surface sculpting and modification through patterning (including formation of nanohole arrays and introduction of ion channels similar in function to those in biological nanomembranes). We also present some of our original results related to functionalization of metal matrix composite nanomembranes.
The Experiences of Parents of Pediatric Patients With Acute Lymphoblastic Leukemia, 2 Months After Completion of Treatment

Diagnosis and treatment of childhood acute lymphoblastic leukemia (ALL) can be a highly stressful time for the entire family. While completion of treatment may bring relief to some families, it may also bring about additional anxieties and fear. The primary objective of this article is to present an analysis of the experiences, emotional states, and support needs of parents of pediatric cancer patients 2 months after treatment completion for ALL. Using a qualitative interpretive description approach, transcripts from interviews with 17 parents from the leukemia/lymphoma program of a large urban pediatric cancer center were analyzed using N-Vivo 10 data analysis software. Parents reported simultaneous feelings of relief and apprehension, changing relationships with their health care team and the experience of returning to a life following treatment. Results highlight the need for support for parents on completion of treatment.
Metformin Is Associated With Slightly Reduced Risk of Colorectal Cancer and Moderate Survival Benefits in Diabetes Mellitus

AbstractTo systematically assess the effect of metformin on colorectal cancer (CRC) risk and mortality in type 2 diabetes mellitus (T2DM) patients.We conducted a systematic search of PubMed, Web of Science, and the Cochrane Library databases for relevant articles before August 2015. Two investigators identified and extracted data independently. We adopted adjusted estimates to calculate summary estimates with 95% confidence interval (CI) using either a fixed-effects or a random-effects model. Subgroup and sensitivity analyses were conducted to evaluate the robustness of the pooled results. The risk of publication bias was assessed by examining funnel plot asymmetry as well as Begg test and Egger test.Fifteen studies on CRC incidence and 6 studies on CRC survival were finally included in our meta-analysis. The pooled odds ratio (OR) of observational studies illustrated that a slight 10% reduction of CRC incidence was associated with metformin use (OR = 0.90, 95% CI: 0.85–0.96). Furthermore, the pooled hazard ratio (HR) revealed an improved survival outcome for metformin users in CRC patients compared to nonusers (HR = 0.68, 95% CI: 0.58–081). There was no publication bias across studies.Our meta-analysis demonstrated that metformin therapy could slightly reduce CRC incidence and moderately improve the survival outcomes in patients with T2DM. More prospective studies are warranted to certify this protective association.
Does colour polymorphism enhance survival of prey populations?

That colour polymorphism may protect prey populations from predation is an old but rarely tested hypothesis. We examine whether colour polymorphic populations of prey exposed to avian predators in an ecologically valid visual context were exposed to increased extinction risk compared with monomorphic populations. We made 2976 artificial pastry prey, resembling Lepidoptera larvae, in four different colours and presented them in 124 monomorphic and 124 tetramorphic populations on tree trunks and branches such that they would be exposed to predation by free-living birds, and monitored their ‘survival’. Among monomorphic populations, there was a significant effect of prey coloration on survival, confirming that coloration influenced susceptibility to visually oriented predators. Survival of polymorphic populations was inferior to that of monomorphic green populations, but did not differ significantly from monomorphic brown, yellow or red populations. Differences in survival within polymorphic populations paralleled those seen among monomorphic populations; the red morph most frequently went extinct first and the green morph most frequently survived the longest. Our findings do not support the traditional protective polymorphism hypothesis and are in conflict with those of earlier studies. As a possible explanation to our findings, we offer a competing ‘giveaway cue’ hypothesis: that polymorphic populations may include one morph that attracts the attention of predators and that polymorphic populations therefore may suffer increased predation compared with some monomorphic populations.
Impact of Preoperative Echocardiography on Perioperative Management in Geriatric Hip Trauma: A Retrospective Observational Study

Background and Aim: Hip fractures are associated with a significant risk of morbidity and mortality in the elderly population. Current guidelines propose that these patients should be operated as early as possible. Preoperative cardiac investigations, especially echocardiography, have been considered to delay surgery with few changes in the patient management. The present study has been conducted to evaluate whether preoperative echocardiography improve or worsen the prognosis in such hip trauma surgery. Materials and Methods: In this retrospective study, we reviewed the records of elderly patients with hip trauma operated in the tertiary care trauma center of our institute over a period of 1 year. Out of 120 patients, preoperative echocardiography was done in 30 patients. We compared the patients for whom echocardiography was done with the patients who did not undergo echocardiography. Descriptive statistical methods were used to analyze the results and observations. Results: We observed that preoperative transthoracic echocardiography led to an escalation in cardiac medication in 53% patients when compared with 23.3% in patients who did not undergo echocardiography. No preoperative cardiac intervention was done in any patient. However, there was a delay of 2.5 days in surgery in the echocardiography group as compared to the patients of nonechocardiography group. Rate of regional anesthesia was comparable in both the groups (54% vs. 56.6%). Conclusions: In the present study, it was observed that echocardiography significantly delays surgery without a significant change in preoperative cardiac medication or anesthesia technique. This may have a potential possible adverse effect on the outcome in geriatric hip trauma which was not observed to a significant limit in the present study as the study was not a longitudinal study. For “fast tracking” of geriatric hip trauma, institutional guidelines should be developed depending on the resources available.
The role of the RM-ODP computational viewpoint concepts in the MDA approach

An MDA design approach should be able to accommodate designs at different levels of platform-independence. We have proposed a design approach previously (in [2]), which allows these levels to be identified. An important feature of this approach is the notion of abstract platform. An abstract platform is determined by the platform characteristics that are relevant for applications at a certain level of platform-independence, and must be established by considering various design goals. In this paper, we define a framework that makes it possible to use RM-ODP concepts in our MDA design approach. This framework allows a recursive application of the computational viewpoint at different levels of platform-independence. This is obtained by equating the RM-ODP notion of infrastructure to our notion of abstract platform.
The Contribution of Verbal Working Memory to Deaf Children’s Oral and Written Production

This study investigated the contribution of verbal working memory to the oral and written story production of deaf children. Participants were 29 severely to profoundly deaf children aged 8–13 years and 29 hearing controls, matched for grade level. The children narrated a picture story orally and in writing and performed a reading comprehension test, the Wechsler Intelligence Scale for Children-Fourth Edition forward digit span task, and a reading span task. Oral and written stories were analyzed at the microstructural (i.e., clause) and macrostructural (discourse) levels. Hearing children’s stories scored higher than deaf children’s at both levels. Verbal working memory skills contributed to deaf children’s oral and written production over and above age and reading comprehension skills. Verbal rehearsal skills (forward digit span) contributed significantly to deaf children’s ability to organize oral and written stories at the microstructural level; they also accounted for unique variance at the macrostructural level in writing. Written story production appeared to involve greater verbal working memory resources than oral story production.
Coexistence of GABA receptors and GABA-modulin in primary cultures of rat cerebellar granule cells

GABA-modulin (GM), a basic polypeptide purified from rat brain synaptosomes, which is an allosteric inhibitor of GABA recognition sites, has been detected in primary cultures of cerebellar interneurons enriched in granule cells by immunohistochemistry, using a specific antibody raised in rabbit injected with GM purified from rat brain synaptosomes. In these cultures, GM is expressed by the granule cells, which are postsynaptic to GABAergic interneurons, but not by glial cells. In rat cerebellar sections anti-GM antiserum intensely strains the granular cell layer and Purkinje cell dendrites and cell bodies. GM has been purified from the cerebellar granule cell cultures and appears to be identical under biochemical, immunological, and functional criteria to authentic GM purified from rat brain synaptosomes. Granule cell cultures devoid of GABAergic neurons contain the GABA/BZ/Cl- receptor complex; in fact, intact cell monolayers, incubated in physiological buffer at 25 degrees C, express 3H-muscimol and 3H- flunitrazepam binding sites, which are comparable to the sites detected in cell membrane preparations and which modulate each other reciprocally. It is concluded that GM might participate in the supramolecular organization of the GABA receptor complex, perhaps functioning as a modulator of this receptor protein.
Testing of Piezo-Actuated Glass Micro-Membranes by Optical Low-Coherence Reflectometry

In this work, we have applied optical low-coherence reflectometry (OLCR), implemented with infra-red light propagating in fiberoptic paths, to perform static and dynamic analyses on piezo-actuated glass micro-membranes. The actuator was fabricated by means of thin-film piezoelectric MEMS technology and was employed for modifying the micro-membrane curvature, in view of its application in micro-optic devices, such as variable focus micro-lenses. We are here showing that OLCR incorporating a near-infrared superluminescent light emitting diode as the read-out source is suitable for measuring various parameters such as the micro-membrane optical path-length, the membrane displacement as a function of the applied voltage (yielding the piezo-actuator hysteresis) as well as the resonance curve of the fundamental vibration mode. The use of an optical source with short coherence-time allows performing interferometric measurements without spurious resonance effects due to multiple parallel interfaces of highly planar slabs, furthermore selecting the plane/layer to be monitored. We demonstrate that the same compact and flexible setup can be successfully employed to perform spot optical measurements for static and dynamic characterization of piezo-MEMS in real time.
A Common Variant in the PTPN11 Gene Contributes to the Risk of Tetralogy of Fallot

Background— Tetralogy of Fallot (TOF) is the commonest cyanotic form of congenital heart disease. In 80% of cases, TOF behaves as a complex genetic condition exhibiting significant heritability. As yet, no common genetic variants influencing TOF risk have been robustly identified. Methods and Results— Two hundred and seven haplotype-tagging single nucleotide polymorphisms in 22 candidate genes were genotyped in a test cohort comprising 362 nonsyndromic British white patients with TOF together with 717 unaffected parents of patients and 183 unrelated healthy controls. Single nucleotide polymorphisms with suggestive evidence of association in the test cohort (P<0.01) were taken forward for genotyping in an independent replication cohort comprising 392 cases of TOF, 218 unaffected parents of patients, and 1319 controls. Significant association was observed for 1 single nucleotide polymorphism, rs11066320 in the PTPN11 gene, in both the test and the replication cohort. Genotype at rs11066320 was associated with a per-allele odds ratio of 1.34 (95% confidence interval [CI], 1.19 to 1.52; P=2.9×10−6) in the total cohort of TOF cases and controls; this remained highly significant after Bonferroni correction for 207 analyses (corrected P=0.00061). Genotype at rs11066320 was responsible for a population-attributable risk of TOF of approximately 10%. Conclusions— Common variation in the linkage disequilibrium block including the PTPN11 gene contributes to the risk of nonsyndromic TOF. Rare mutations in PTPN11 are known to cause the autosomal dominant condition Noonan syndrome, which includes congenital heart disease, by upregulating Ras/mitogen-activated protein kinase (MAPK) signaling. Our results suggest a role for milder perturbations in PTPN11 function in sporadic, nonsyndromic congenital heart disease.
Outage Probability Under Channel Distribution Uncertainty

Outage probability and capacity of a class of block fading MIMO channels are considered under partial channel distribution information. Specifically, the channel or its distribution is not known but the latter is known to belong to a class of distributions where each member is within a certain distance (uncertainty) from a nominal distribution. Relative entropy is used as a measure of distance between distributions. Compound outage probability defined as min (over the transmitted signal distribution) -max (over the channel distribution class) outage probability is introduced and investigated. This generalizes the standard outage probability to the case of partial channel distribution information. Compound outage probability characterization (via 1-D convex optimization and in a closed form), its properties, and approximations are given. It is shown to have two-regime behavior: when the nominal outage probability decreases (e.g., by increasing the SNR), the compound outage first decreases linearly down to a certain threshold (related to the relative entropy distance; this is the nominal outage-dominated regime) and then only logarithmically (i.e., very slowly; this is the uncertainty-dominated regime) so that no significant further decrease is possible. This suggests the following design guideline: the outage probability is decreased by increasing the SNR or optimizing the transmitted signal distribution (both decrease nominal outage) in the first regime and by reducing the channel distribution uncertainty (e.g., via better estimation) in the second one. The compound outage depends on the relative entropy distance and the nominal outage only, all other details (nominal fading and noise distributions) being irrelevant. The transmit signal distribution optimized for the nominal channel distribution is shown to be also optimal for the whole class of distributions. The effect of swapping the distributions in relative entropy is investigated and an error floor effect is established. The compound outage probability under Lp distance constraint is also investigated. The obtained results hold in full generality, i.e., for the general channel model with arbitrary nominal fading and noise distributions.
Testing Cloud Benchmark Scalability with Cassandra

NoSQL databases were developed as highly scalable databases that allow easy data distribution over a number of servers. With the increased interest of researchers and companies in non-relational technology, NoSQL databases became widely used and a common belief emerged defending that those engines scale well. This means that the use of more nodes would result in reduced execution time of requests and the system would scale adequately, by adding nodes proportionally to data size and load. However, sometimes, adding nodes may not result in improvement of request-serving time. Therefore, it is useful to investigate how different factors, such as workload, data size and number of simultaneous sessions influence scaling capabilities. We will review the architecture of Cassandra, which is known for being one of the most efficient NoSQL engines, and analyze its scalability, using the Yahoo Cloud Serving Benchmark. The results will allow a better understanding of scalability and scalability limitations in that type of environment.