Miracle-dz/UniFAR-FTUs huggingface dataset:
Regulation of dihydrodipicolinate synthase and aspartate kinase in Bacillus subtilis

The regulation of dihydrodipicolinate synthase (EC 4.2.1.52) and aspartate kinase (EC 2.7.2.4) was studied in Bacillus subtilis 168. Starvation for lysine gave depression of one aspartate kinase isoenzyme but not of dihydrodipicolinate synthase. Strains resistant to growth inhibition by the lysine analogue thiosine exhibited constitutively derepressed synthesis of one aspartate kinase isoenzyme but had normal levels of dihydrodipicolinate synthase. The data provide strong evidence that lysine is not the signal for derepression of dihydrodipicolinate synthase. Nevertheless, dihydrodipicolinate synthase specific activity increased during sporulation, and it is suggested that this increase may result, in part, from resistance to proteolysis of that enzyme.
Risk-Limiting Postelection Audits: Conservative $P$-Values From Common Probability Inequalities

Postelection audits of a random sample of batches of ballots against a trustworthy audit trail can limit the risk of certifying an incorrect electoral outcome to alpha, guaranteeing that - if the apparent outcome is wrong - the chance of a full hand count of the audit trail is at least 1-alpha. Risk-limiting audits can be built as sequential tests that audit more batches until either 1) there is strong evidence that the outcome is correct, given the errors found, or 2) there has been a complete hand count. The P -value of the hypothesis that the outcome is wrong is the largest chance, for all scenarios in which the outcome is wrong, that overstatements of the margins between winners and losers would be ldquono largerrdquo than they were observed to be. Different definitions of ldquolargerrdquo give different P -values. A small P -value is strong evidence that the outcome is correct. This paper gives simple approaches to calculating a conservative P-value for several ways of summarizing overstatements and several ways of drawing the sample of batches to audit, emphasizing sampling with probability proportional to a bound up on the error in the pth audit batch (PPEB sampling). A P-value based on Markov's inequality applied to a martingale constructed from the data seems the most efficient among the methods discussed; there are plans to use it to audit contests in two California counties in November 2009.
Biomarkers heat up during earthquakes: New evidence of seismic slip in the rock record

During earthquakes, faults heat up due to frictional work. However, evidence of heating from paleoearthquakes along exhumed faults remains scarce. Here we describe a method using thermal maturation of organic molecules in sedimentary rock to determine whether a fault has experienced differential heating compared to surrounding rocks. We demonstrate the utility of this method on an ancient, pseudotachylyte-hosting megathrust at Pasagshak Point, Alaska. Measurements of the ratio of thermally stable to thermally unstable compounds (diamondoids/n-alkanes) show that the melt-bearing rocks have higher thermal maturity than surrounding rocks. Furthermore, the mineralogy of the survivor grains and the presence of any organic molecules allow us to constrain the temperature rise during the ancient earthquakes to 840–1170 °C above ambient temperatures of ~260 °C. From this temperature rise, we estimate that the frictional work of the earthquake was ~105–228 MJ/m 2 . Using experimental friction measurements as a constraint, we estimate that the minimum slip necessary for heating was ~1–8 m. This paper demonstrates that biomarkers will be a useful tool to identify seismic slip along faults without frictional melt.
Load-aware channel selection for 802.11 WLANs with limited measurement

It has been known that load unaware channel selection in 802.11 networks results in high level interference, and can significantly reduce the network throughput. In current implementation, the only way to determine the traffic load on a channel is to measure that channel for a certain duration of time. Therefore, in order to find the best channel with the minimum load all channels have to be measured, which is costly and can cause unacceptable communication interruptions between the AP and the stations. In this paper, we propose a learning based approach which aims to find the channel with the minimum load by measuring only limited number of channels. Our method uses Gaussian Process Regressing to accurately track the traffic load on each channel based on the previous measured load. We confirm the performance of our algorithm by using experimental data, and show that the time consumed for the load measurement can be reduced up to 46% compared to the case where all channels are monitored.
Prevention and control of iodine deficiency in pregnant and lactating women and in children less than 2-years-old: conclusions and recommendations of the Technical Consultation

The Consultation reached a general consensus on several important issues. First, that universal salt iodisation‡ (USI) remains the key strategy to eliminate iodine deficiency disorders. Second, that where USI has been effective for at least 2 years, with salt adequately iodised and consumed by more than 90% of the population 1 , it can be reasonably expected that the iodine needs of women of child-bearing age and pregnant and lactating women are covered by their diet, and that the iodine stored in the thyroid gland is sufficient to ensure adequate hormone synthesis and secretion. Third, that iodised salt may not provide enough iodine to meet a child’s needs during complementary feeding, especially if the mother is only marginally iodine sufficient, unless complementary foods are fortified with iodine. It may be necessary therefore to give additional iodine to makesure that requirements are met until such time as the child starts to eat the normal family food. Finally, there was consensus that monitoring of both iodised salt quality and iodine nutrition are important to ensure that an optimal state of iodine nutrition is reached and then sustained. The Consultation made several specific recommendations concerning requirements, indicators and strategies to control iodine deficiency disorders in pregnant and lactating women, and in children less than 2-years-old.
How enhancing information and communication technology has affected inequality in Africa for sustainable development: An empirical investigation

This study examines if enhancing ICT reduces inequality in 48 countries in Africa for the period 2004-2014. Three inequality indictors are used, namely, the: Gini coefficient, Atkinson index and Palma ratio. The adopted ICT indicators include: mobile phone penetration, internet penetration and fixed broadband subscriptions. The empirical evidence is based on the Generalised Method of Moments. Enhancing internet penetration and fixed broadband subscriptions have a net effect on reducing the Gini coefficient and the Atkinson index, whereas increasing mobile phone penetration and internet penetration reduces the Palma ratio. Policy implications are discussed in the light of challenges to Sustainable Development Goals.
Phylogenetic background of E. coli isolated from asymptomatic pregnant women from Kolkata, India.

INTRODUCTION Asymptomatic bacteriuria (ABU) in pregnancy generates medical complications. E. coli is the common etiologic agent responsible for ABU-associated infections. This study aimed to identify the phylogenetic background and drug resistance in asymptomatic E. coli from a pregnant population. METHODOLOGY E. coli was confirmed biochemically from culture-positive urine samples collected from asymptomatic pregnant women. Phylogenetic typing was done by polymerase chain reaction (PCR). The isolates were subjected to antibiotic susceptibility testing and extended-spectrum beta-lactamase (ESBL) production. Statistical significance was determined using SPSS 17.0 software. RESULTS Bacteriuria was observed in 113 (22.6%) of 500 asymptomatic pregnant females. E. coli was reported in 44 (38.9%) of 113 isolates. The mean age-wise distribution was 25.14 ± 4.63. Although pathogenic phylogroup B2 was predominant (54.5%), incidence of non-pathogenic phylogroup B1 (27.3%) was found to be statistically significant (p ≤ 0.001), and B1 and B2 were correlated with respect to total ABU population. Antibiotic sensitivity against ampicillin (34.1%), ceftazidime (50%), cefotaxime (47.7%), ciprofloxacin (47.7%), amikacin (86.4%), nitrofurantion (79.5%), and co-trimoxazole (36.4%) was observed. Multidrug resistance (MDR) and ESBL production was reported in 26 (59.1%) of 44 and 18 (69.2%) of the 26 MDR isolates, respectively. A significant distribution of phylogroup B1 (p = 0.03) with drug resistance was also observed. CONCLUSIONS This is the first study that reported significant incidence of non-pathogenic phylogroup B1 in asymptomatic E. coli with high incidence of MDR isolated from pregnant women in Kolkata, India. These varied resistance patterns present major therapeutic and infection control challenges during pregnancy.
Flight in slow motion: aerodynamics of the pterosaur wing

The flight of pterosaurs and the extreme sizes of some taxa have long perplexed evolutionary biologists. Past reconstructions of flight capability were handicapped by the available aerodynamic data, which was unrepresentative of possible pterosaur wing profiles. I report wind tunnel tests on a range of possible pterosaur wing sections and quantify the likely performance for the first time. These sections have substantially higher profile drag and maximum lift coefficients than those assumed before, suggesting that large pterosaurs were aerodynamically less efficient and could fly more slowly than previously estimated. In order to achieve higher efficiency, the wing bones must be faired, which implies extensive regions of pneumatized tissue. Whether faired or not, the pterosaur wings were adapted to low-speed flight, unsuited to marine style dynamic soaring but adapted for thermal/slope soaring and controlled, low-speed landing. Because their thin-walled bones were susceptible to impact damage, slow flight would have helped to avoid injury and may have contributed to their attaining much larger sizes than fossil or extant birds. The trade-off would have been an extreme vulnerability to strong or turbulent winds both in flight and on the ground, akin to modern-day paragliders.
Origin of the Metazoan Immune System: Identification of the Molecules and Their Functions in Sponges1

Abstract During the evolutionary transition to Metazoa, cell-cell- as well as cell-matrix recognition molecules have been formed, which made a further step in evolution possible, the establishment of an immune system. Sponges [Porifera] represent the oldest still extant metazoan phylum and consequently testify to major features of the common metazoan ancestor, the Urmetazoa. Most studies with respect to evolution and phylogeny in sponges have been performed with the marine demosponges Suberites domuncula and Geodia cydonium. These animals possess effective defense systems against microbes and parasites which involve engulfment of bacteria into specific cells, but also signal transduction pathways which actively kill bacteria. Among those is the LPS-mediated pathway, with the stress-responsive kinases. In addition, sponges are provided with an interferon-related system, with the (2–5)A synthetase as controlling enzyme. Transplantation studies have been performed on tissue, as well as at the cellular level (“mixed sponge cell reaction assay”) which demonstrate the complex molecular strategy by which sponges respond to allogeneic- and/or autogeneic signals. Among the molecules involved in histo(in)compatibility response of sponges, cytokines e.g., the allograft inflammatory factor 1, have been identified which control rejection of allografts. Furthermore, transcription factors, with Tcf-like factor as an example, have been identified which very likely control gene expression during histocompatibility reactions. The immune reactions in sponges can be modulated by FK506, a drug which has been successfully used as immunosuppressant in humans. One further surprising finding is the fact that G. cydonium has several molecules containing polymorphic Ig-like domains of the variable type. It is concluded that the successful evolutionary transition to the Metazoa, with the sponges as the oldest still extant phylum, and the subsequent rapid radiation into the other metazoan phyla, became possible because of the acquisition of modular molecules, involved in cell adhesion and the immune system.
Mating system variation drives rapid evolution of the female transcriptome in Drosophila pseudoobscura

Interactions between the sexes are believed to be a potent source of selection on sex-specific evolution. The way in which sexual interactions influence male investment is much studied, but effects on females are more poorly understood. To address this deficiency, we examined gene expression in virgin female Drosophila pseudoobscura following 100 generations of mating system manipulations in which we either elevated polyandry or enforced monandry. Gene expression evolution following mating system manipulation resulted in 14% of the transcriptome of virgin females being altered. Polyandrous females elevated expression of a greater number of genes normally enriched in ovaries and associated with mitosis and meiosis, which might reflect female investment into reproductive functions. Monandrous females showed a greater number of genes normally enriched for expression in somatic tissues, including the head and gut and associated with visual perception and metabolism, respectively. By comparing our data with a previous study of sex differences in gene expression in this species, we found that the majority of the genes that are differentially expressed between females of the selection treatments show female-biased expression in the wild-type population. A striking exception is genes associated with male-specific reproductive tissues (in D. melanogaster), which are upregulated in polyandrous females. Our results provide experimental evidence for a role of sex-specific selection arising from differing sexual interactions with males in promoting rapid evolution of the female transcriptome.
The effect of glutamine on oxidative damage in an experimental abdominal compartment syndrome model in rats.

BACKGROUND The aim was to investigate whether or not glutamine, an antioxidant effective amino acid, improves the reperfusion-induced oxidative injury of abdominal hypertension. METHODS Wistar Albino rats were used. Group 1: Abdominal compartment syndrome alone: With the rats under anesthesia, intraabdominal pressure was obtained. Three days later, the rats were sacrificed, and intestine, lung and liver samples were removed for determination of tissue malondialdehyde (MDA) and glutathione (GSH) levels as oxidative injury parameters and of myeloperoxidase (MPO) activity as an inflammatory parameter. Trunk blood was analyzed for the alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels. Group 2: Abdominal compartment syndrome and glutamine: intragastric glutamine was given for seven days before and three days following establishment of the abdominal compartment syndrome model. The same examination procedure was then performed. Group 3: Glutamine administration alone. Group 4: Control group. RESULTS Intraabdominal pressure significantly increased the intestine, lung and liver MDA levels and MPO activities in comparison to the control group. Glutamine was associated with decreased MDA levels and MPO activities and increased GSH levels. CONCLUSION Glutamine appears to have protective effects against reperfusion-induced oxidative damage via its anti-inflammatory and antioxidant effect.
SATD-based joint decision algorithm for parallelized intra prediction encoder in H.265/HEVC

A Hadamard transformed sum of absolute difference (SATD)-based joint decision algorithm (SJDA) is proposed for intra prediction encoder in High Efficiency Video Coding. The SJDA performs the SATD-only distortion costs in 4×4 prediction units (PUs) to select rough modes of larger PUs. An adaptive block selection scheme is proposed in SJDA to adaptively adjust the PU sizes every 16×16 block by an approximate SATD-based rate distortion cost. To smartly select intra prediction modes that will be enabled for rate-distortion optimization (RDO) calculations, the SJDA proposes a novel evaluation signaled scheme to signal the evaluation results to a decision module by deriving a decision rule. Compared to HM, the SJDA averagely saves 73% encoding time with +3.3% BD-rate, while reducing 60% RDO modules in a parallelized encoder, 80% SATD operations, and 77% RDO operations. Simulations also show the proposed algorithms are superior to classical ones.
Bell's Palsy Treatment with Acyclovir and Prednisone Compared with Prednisone Alone: A Double-Blind, Randomized, Controlled Trial

In a double-blind study, we compared the final outcome of 99 Bell's palsy patients treated with either acyclovir-prednisone (53 patients) or placebo-prednisone (46 patients). For patients receiving acyclovir, the dosage was 2,000 mg (400 mg 5 times daily) for 10 days. Electrical tests included electroneurography and the maximal stimulation test. Univariate comparisons of outcome and electrical tests between the two groups were made with χ2 analysis, Fisher's exact test, and t-tests. The outcome in acyclovir-prednisone-treated patients was superior to that in placebo-prednisone-treated patients. Treatment with acyclovir-prednisone was statistically more effective in returning volitional muscle motion (recovery profile of 10; p = .02) and in preventing partial nerve degeneration (p = .05) than placebo-prednisone treatment. The t-tests indicated that the recovery profile and index means were significantly better for the acyclovir-treated group (recovery profile t = 1.99, p = .051; recovery index t = 2.10, p = .040). We conclude that acyclovir-prednisone is superior to prednisone alone in treating Bell's palsy patients and suggest that herpes simplex is the probable cause of Bell's palsy.
Rhetorical Strategies in Student Persuasive Writing: Differences between Native and Non-Native English Speakers

Persuasive/argumentativew riting is an importanta nd difficult mode of discourse for student writers. It is particularly problematic for non-native speakers, who often bring both linguistic and rhetorical deficits to the task of persuasion in English. This study analyzed 60 persuasive texts by university freshman composition students, half of whom were native speakers and half of whom were non-native speakers of English for 33 quantitative, topical structure, and rhetorical variables. The results showed clear differences between the essays of native and non-native speakers. These results and their implications for second language composition instruction are discussed.
Maritime surveillance radar-Part 2: Detection performance prediction in sea clutter

Techniques for detection performance prediction for maritime surveillance radars are described, with particular emphasis on the use of the compound K-distribution model for radar sea clutter. The paper first briefly reviews the analyti­ cal methods for deriving theoretical detection per­ formance limits using compound models for both clutter and targets. Next, it is shown how the clutter environment is modelled for radar design evaluation, and methods whereby the radar may adapt to this changing environment for optimum target detection performance are described. This is followed by a description of a new method for performance prediction for a cell-averaging CF AR in real clutter, using recorded clutter signals but avoiding lengthy computer simulations. Finally, possible future developments of maritime sur­ veillance radars are discussed.
A life span approach to the relationship between cholesterol, late onset Alzheimer's disease, and cognitive functioning among older adults

OF DISSERTATION A LIFE SPAN APPROACH TO THE RELATIONSHIP BETWEEN CHOLESTEROL, LATE ONSET ALZHEIMER’S DISEASE, AND COGNITIVE FUNCTIONING AMONG OLDER ADULTS There is evidence that cholesterol presents an important risk factor for Alzheimer’s disease (AD), but the direction of this relationship is modified by age. High cholesterol during midlife and low cholesterol during late life are both associated with an increased risk for AD. This dissertation research engaged a life span approach to study the relationship between cholesterol, AD and cognitive functioning among older adults. The purpose of this research was to determine if trajectories of cholesterol from midlife through late life differ according to AD status and if these trajectories are associated with cognitive functioning during old age. This research employed a secondary analysis of cognitive, phenotypic and genetic data collected from subjects of the Framingham Heart Study (FHS) Original and Offspring Cohorts. Aim One involved creating three summary scores of the FHS neuropsychological battery. ROC analysis was used to determine which score best differentiated between cognitively normal, impaired and dementia subjects. Aim Two used generalized additive mixed models to examine trajectories of total, HDL and total/HDL cholesterol ratio according to AD status in the Original Cohort. Aim Three used mixed-effects models to examine the relationship between subject-specific trajectories of total cholesterol and cognition during old age. Aim One determined that a summary score that provided equal weight to each assessment in the FHS neuropsychological battery best differentiates between subjects classified as cognitively normal, cognitively impaired and dementia. The findings from Aim Two indicated that there are subtle differences in the longitudinal trajectories of total, HDL and total/HDL ratio according to AD status. The findings from Aim Three provide limited evidence for a relationship between subject-specific trajectories of total cholesterol and cognitive functioning later in life. Older adults in the highest quartile for cognitive functioning had lower total cholesterol at approximately 55 years of age, but there were no differences in the mean trajectories of total cholesterol according to cognitive functioning later in life. The findings from this research suggest that older adults with high cognitive functioning have lower total cholesterol during midlife, but life span cholesterol trajectories do not appear to be associated with AD status or cognitive function.