Miracle-dz/UniFAR-FTUs huggingface dataset:
The Feasibility of Telephone Follow-Up Interviews for Monitoring Treatment Outcomes of Australian Residential Drug and Alcohol Treatment Programs

Background Telephone follow-up interviewing is one method of monitoring treatment outcomes of individuals involved in drug and alcohol treatment programs. The present study is the first to examine the feasibility and generalizability of data obtained from telephone follow-up interviews after drug and alcohol treatment in Australia. Methods Participants attended 1 of 8 Salvation Army Recovery Service Centres where staff administered outcome measures at intake. Three-month postdischarge telephone follow-up interviews were conducted by researchers from the Illawarra Institute for Mental Health, University of Wollongong. Results A sample of 700 clients was obtained for follow-up (582 males; 118 females). A 51% follow-up rate was achieved at a cost of US$82 per completed interview. No significant differences in baseline characteristics between responding and nonresponding participants were found. Conclusions Overall, the telephone methodology was shown to be feasible and relatively inexpensive. However, the introduction of outcome measures at the service level in parallel with follow-up data collection procedures complicated the collection of response data. The burden of introducing outcome measures in residential services may be reduced by utilizing a phased implementation strategy.
PCTopk: Privacy-and Correctness-Preserving Functional Top-k Query on Un-trusted Data Storage in Two-Tiered Sensor Networks

This paper proposes an efficient mechanism, called PCTopk, for functional top-k query with a combination of multiple conditions/dimensions in two-tiered sensor networks to simultaneously preserve data privacy and correctness (i.e., authenticity and integrity). PCTopk constructs a layered authentication tree, cooperated with an order-preserving symmetric encryption technique, for only permitting storage nodes to systematically process inquired data over encryption domain and enabling querists to efficiently verify the authentic and complete query results. To the best of our knowledge, this is the first research work on the issue of secure functional top-k query with a combination of multiple conditions in two-tiered sensor networks. The performance evaluation results show that PCTopk takes significantly less energy consumption and storage space than prior arts while preserving data privacy and correctness.
Nurses' perceptions of individualized care: an international comparison.

AIM This paper is a report of a study of internationally-based differences in nurses' perceptions of individualized care in orthopaedic surgical in-patient wards. BACKGROUND Individualized care is valued in healthcare policy, practice and ethical statements as an indicator of care quality. However, nurses' assessments of individualized care are limited and comparative cross-cultural studies on individualized nursing care are lacking. METHODS A descriptive comparative survey was used to sample orthopaedic surgical nurses (n = 1163) working in 91 inpatient wards in 34 acute hospitals in Finland, Cyprus, Greece, Portugal, Sweden, Turkey and the United States of America. Data were collected between March and November 2009 using the Individualized Care Scale-Nurse and analysed using descriptive and inferential statistics. RESULTS Nurses in different countries perceived that they supported patients' individuality generally and provided individualized care during nursing activities. Although the highest scores were in support of patients' individuality in the clinical situation both through nursing provision and nurses' perceptions of individuality, there were between-country differences within these scores. Generally, the Greek and American nurses gave the highest scores and the Turkish, Cypriot and Portuguese nurses the lowest. CONCLUSIONS Between-country differences found may be attributed to differing roles of nurses, care processes, healthcare systems and/or the ways nursing care is defined and organized. As this was the first time the Individualized Care Scale-Nurse was used in an international context, the results are formative and indicate the need to continue studies in this area.
Influence of the Polysilicon Gate on the Random Dopant Induced Threshold Voltage Fluctuations in Sub 100 nm MOSFETs with Thin Gate Oxides

In this paper for the first time we study the influence of the polysilicon gate on the random dopant induced threshold voltage fluctuations in sub 100 nm MOSFETs with tunnelling gate oxides. This is done by using an efficient 3D 'atomistic' simulation technique described elsewhere. Devices with uniform channel doping and with low doped epitaxial channels have been investigated. The simulations reveale that the polysilicon gate is responsible for a substantial fraction of the threshold voltage fluctuations in both devices when the gate oxide is scaled to tunnelling thickness in the range of 1 - 2 nm.
Morbidity in immunosuppressed (SCID/NOD) mice treated with reovirus (Dearing 3) as an anti-cancer biotherapeutic

Specific viral oncolysis of cancer cells has aroused great interest as a potential anti-cancer therapy. Reovirus was proposed as an anti-cancer biotherapeutic several years ago, as it elicits virus-mediated death of human cancer cells both in vitro and in mouse model systems. A common model system for reovirus oncolysis is the NOD/LtSz-scid/scid (SCID/NOD) immunocomprimised mouse. While human tumour xenografts are effectively killed by intra-tumour injections of reovirus, the mice often exhibit discoloration and necrosis of extremities including feet, distal leg, tail and ears several weeks after injection. This phenomenon never occurs in sham-injected mice, nor is it observed in wild type or nude mice. The pathogenesis of this "Black Foot" lesion has not yet been described, but may be of relevance for future human studies of biotherapeutics. Examination of SCID/NOD mice was performed at various time points following intratumoral injection of reovirus. Immunohistological evaluation of tissues reveals infection of cardiac myocytes and venous endothelial cells at approximately 2 days post infection. Over time, venules and veins showed a mixed inflammatory vasculitis and thrombus formation. Synchronously, the heart showed diffuse myocyte death, with dystrophic calcification. The results indicate that the "Black Foot" syndrome is likely due to venous vasculitis secondary to reovirus infection, on a background of reovirus myocarditis and heart failure. The rationale for the selective susceptibility of venous over arterial endothelium to reovirus infection is currently unknown. The results of this study may be relevant to the use of oncolytic viruses, particularly reovirus, in the anti-cancer therapy of immunosuppressed patients.
Evolution of Alu Subfamily Structure in the Saimiri Lineage of New World Monkeys

Abstract Squirrel monkeys, Saimiri, are commonly found in zoological parks and used in biomedical research. S. boliviensis is the most common species for research; however, there is little information about genome evolution within this primate lineage. Here, we reconstruct the Alu element sequence amplification and evolution in the genus Saimiri at the time of divergence within the family Cebidae lineage. Alu elements are the most successful SINE (Short Interspersed Element) in primates. Here, we report 46 Saimiri lineage specific Alu subfamilies. Retrotransposition activity involved subfamilies related to AluS, AluTa10, and AluTa15. Many subfamilies are simultaneously active within the Saimiri lineage, a finding which supports the stealth model of Alu amplification. We also report a high resolution analysis of Alu subfamilies within the S. boliviensis genome [saiBol1].
Enhancing Biomedical Ontologies through Alignment of Semantic Relationships: Exploratory Approaches

OBJECTIVE This paper investigates several methods for aligning Metathesaurus relationships with their counterparts in the UMLS Semantic Network. Unlike the categorization link defined between Metathesaurus concepts and Semantic Network types, no such correspondence exists between the relationships at these two levels of the UMLS. METHODS The first approach attempts to elicit the semantics of Metathesaurus relationships through an examination of their relata at different levels: concept, high-level ancestors and semantic types. The second approach examines the frequency of association between a given Semantic Network relationship and the actual relationships observed in the Metathesaurus between the concepts categorized by these semantic types. RESULTS A total of 139 relationships are present in the Metathesaurus. Using the methods described in this paper, 80 (58%) could be aligned with Semantic Network relationships. The remaining relationships are vocabulary internal, used, for example, for vocabulary management or to indicate strictly lexical relationships. The work reported here is a first step in the attempt to build a more comprehensive ontology of biomedical relationships.
Decidability problems for the prenex fragment of intuitionistic logic

We develop a constraint-based technique which allows one to prove decidability and complexity results for sequent calculi. Specifically, we study decidability problems for the prenex fragment of intuitionistic logic. We introduce an analogue of Skolemization for intuitionistic logic with equality, prove PSPACE-completeness of two fragments of intuitionistic logic with and without equality and some other results. In the proofs, we use a combination of techniques of constraint satisfaction, loop-free sequent systems of intuitionistic logic and properties of simultaneous rigid E-unification.
Ecosystem engineers: from pattern formation to habitat creation.

Habitat and species richness in drylands are affected by the dynamics of a few key species, termed "ecosystem engineers. " These species modulate the landscape and redistribute the water resources so as to allow the introduction of other species. A mathematical model is developed for a pair of ecosystem engineers commonly found in drylands: plants forming vegetation patterns and cyanobacteria forming soil crusts. The model highlights conditions for habitat creation and for high habitat richness, and suggests a novel mechanism for species loss events as a result of environmental changes.
Multivitamin-Mineral Supplementation Prevents Lipid Peroxidation during “The Marathon des Sables”

Objective: We investigated the effect of a moderate mutivitamin and mineral supplementation containing mainly vitamin C (150.0 mg.day−1), vitamin E (24.0 mg.day−1) and β-carotene (4.8 mg.day−1) prior to and during an extreme running competition -the Marathon des Sables (MDS)- that consisted of six long races in the desert. Methods: Seventeen athletes participated in our double blind, placebo-controlled study. Blood samples were collected prior to the supplementation i.e. three weeks before the competition (D-21), two days prior to the MDS (D-2), after the third race (D3) and at the end of the competition (D7). Erythrocyte antioxidant enzyme activity (glutathione peroxidase (GPx), superoxide dismutase (SOD)), erythrocyte glutathione level (GSH), plasma non-enzymatic antioxidant status (uric acid, vitamin C, α-tocopherol, retinol, β-carotene), markers of plasma lipid peroxidation (thiobarbituric reactive substances (TBARS)), reactive carbonyl derivatives (RCD) and membrane damage (creatine kinase and lactate dehydrogenase activities) were measured. Results: In both groups, GSH levels, uric acid levels and membrane damage significantly increased during the competition while SOD activity significantly decreased. In Supplemented group, plasma α-tocopherol, β-carotene and retinol levels significantly increased after three weeks of supplementing. In contrast to Placebo group, α-tocopherol, vitamin C and retinol levels were significantly affected by the competition in Supplemented group. Moreover, no increase in TBARS was observed in Supplemented group during the competition, whereas TBARS significantly increased at D3 in the placebo group. Conclusion: The moderate multivitamin-mineral supplementation prevented the transient increase in TBARS levels during this extreme competition.
Stigma as Ego Depletion

This research examined whether stigma diminishes people's ability to control their behaviors. Because coping with stigma requires self-regulation, and self-regulation is a limited-capacity resource, we predicted that individuals belonging to stigmatized groups are less able to regulate their own behavior when they become conscious of their stigmatizing status or enter threatening environments. Study 1 uncovered a correlation between stigma sensitivity and self-regulation; the more Black college students were sensitive to prejudice, the less self-control they reported having. By experimentally activating stigma, Studies 2 and 3 provided causal evidence for stigma's ego-depleting qualities: When their stigma was activated, stigmatized participants (Black students and females) showed impaired self-control in two very different domains (attentional and physical self-regulation). These results suggest that (a) stigma is ego depleting and (b) coping with it can weaken the ability to control and regulate one's behaviors in domains unrelated to the stigma.
A new method for recognizing hand configurations of Brazilian gesture language

This paper describes a new method for recognizing hand configurations of the Brazilian Gesture Language - LIBRAS - using depth maps obtained with a Kinect® camera. The proposed method comprised three phases: hand segmentation, feature extraction, and classification. The segmentation phase is independent from the background and depends only on pixel depth information. Using geometric operations and numerical normalization, the feature extraction process was done independent from rotation and translation. The features are extracted employing two techniques: (2D)2LDA and (2D)2PCA. The classification is made with a novelty classifier. A robust database was constructed for classifier evaluation, with 12,200 images of LIBRAS and 200 gestures of each hand configuration. The best accuracy obtained was 95.41%, which was greater than previous values obtained in the literature.
Health risks and risk-taking behaviors among International Committee of the Red Cross (ICRC) expatriates returning from humanitarian missions.

OBJECTIVE To assess self-reported health risk and risk-taking behavior of humanitarian expatriates. METHODS A self-administered anonymous questionnaire was completed by International Committee of the Red Cross (ICRC) expatriates returning during May 2003 to September 2004, covering perceived health status before and after mission, malaria prevention, prevalence of exposure to stress, accidents and violence, and risk-taking behaviors. FINDINGS More than one-third (36.4%) reported worse health on return from the mission. A third (35%) of expatriates returning from Sub-Saharan Africa excl. South Africa reported not having followed ICRC's recommendation on taking malaria prophylaxis in spite of stating a high degree of awareness of the risks and availability of effective drugs. Over 40% reported the mission having been more stressful than expected, mostly due to the working environment; 10% reported injury or accidents and 16.2% exposure to at least one act of violence. Almost one-third of the respondents reported having engaged in casual sexual relationships. Of these, 64% reported using condoms at every sexual contact, and women reported lower usage of condoms than men. Many (27%) reported involvement in risk-taking behavior. CONCLUSION This study shows that humanitarian aid workers experience significant worsening of their health during overseas missions. Many are at risk of experiencing violence, accidents, or injuries. Despite awareness of the risks, many expatriates engage in behaviors that could endanger their health. Improved selection of expatriate staff, training programs emphasizing areas of concern, strengthening social support locally, and follow-up in field may help to alleviate these problems.
Heat Injury to Cells in Perfused Systems

Abstract: Tissue injury in response to excessive heat results in a clinical burn. Burns cause a range of physiologic derangements, including denaturation of macromolecular structures, leakage of cell membranes, activation of cytokines, and cessation of blood flow, all leading to tissue death. The purpose of this paper is to examine the mechanisms and consequences of burn injury and to discuss potential therapies based on these mechanisms. Knowledge of the thermal properties of tissues can predict the time‐temperature relationship necessary to cause a specified thermal insult. Changes in cell membrane biochemistry and the stabilization of proteins through the heat‐shock response can enable biomacromolecules to withstand supraphysiological temperatures. Mechanisms of cellular repair allow recovery of cellular function after thermal insult. An understanding of the response of proteins, cellular organelles, and cells to heat provides the foundation for understanding the pathophysiology and treatment of burn injury. The physics, biochemistry, and cellular biology behind the host response to thermal injury in perfused systems are reviewed.
A 1.5 mW 68 dB SNDR 80 Ms/s 2 $\times$ Interleaved Pipelined SAR ADC in 28 nm CMOS

This paper presents a power-efficient 80 MS/s, 11 bit ENOB ADC. It is realized in 28 nm CMOS and is based on two interleaved pipelined SAR ADCs. It includes an on-chip reference generator and does not require any external components. The total power dissipation is 1.5 mW, resulting in a low-frequency Walden FOM of 9.1 fJ/conv-step and a low-frequency Schreier FOM of 172.2 dB, which is the largest FOM reported to date for sampling frequencies larger than 1 MS/s. The key aspects in achieving this excellent power efficiency include the choice of ADC architecture, integrator-based amplifiers used for noise filtering, the finite settling of the reference voltage during the SAR conversion, and the modified DAC switching scheme to reduce the DAC switching energy.
Trips Down Memory Lane: Recall Direction Affects the Subjective Distance of Past Events

The subjective temporal distance of a past event—how close or far away it feels—is influenced by numerous factors apart from actual time. The current studies extend research on subjective distance by exploring the experience of remembering autobiographical events as part of a stream of related events. The temporal direction in which events are recalled was proposed as a key determinant of subjective distance. Five experiments supported the hypothesis that people feel closer to a target event when they recall a stream of related events in a backward direction (i.e., a reverse-chronological order ending with the target event) rather than a forward direction (i.e., a chronological order beginning with the target event). The effect of recall direction was mediated by people's perceptions of change in their lives. Backward recall created the impression that relatively little had changed since the target event, which in turn made the event feel closer.
Video Outside Versus Video Inside the Web: Do Media Setting and Image Size Have an Impact on the Emotion-Evoking Potential of Video?.

To explore the educational potential of video-evoked affective responses in a Web-based environment, the question was raised whether video in a Web-based environment is experienced differently from video in a traditional context. An experiment was conducted that studied the affect-evoking power of video segments in a window on a computer screen compared to presenting the same video materials on a television monitor. The study first demonstrates that affect-evoking power of video exists. Although not always significant, the results who that selected positive and negative video clips induce positive or negative affective responses and mood changes in participants, in a Web-based environment as well as in a television environment. Smaller window sizes, however, may do less well.
Opioids Inhibit Angiogenesis in a Chorioallantoic Membrane Model.

BACKGROUND Angiogenesis is an important characteristic of cancer. Switching from the avascular phase to the vascular phase is a necessary process for tumor growth. Therefore, research in cancer treatment has focused on angiogenesis as a drug target. Despite the widespread use of opioids to treat pain in patients with cancer, little is known about the effect of these drugs on vascular endothelium and angiogenesis. OBJECTIVES We aimed to investigate the efficacies of morphine, codeine, and tramadol in 3 different concentrations on angiogenesis in hens' eggs. STUDY DESIGN This is a prospective, observational, controlled, in-vivo animal study. SETTING Single academic medical center. METHODS This study was conducted on the chorioallantoic membrane (CAM) of fertilized hens' eggs. The efficacies of morphine, codeine, and tramadol in 3 different concentrations were evaluated on angiogenesis in a total of 165 hens' eggs. RESULTS Statistically significant differences were found between drug-free agarose used as a negative control and concentrations of morphine of 10 µM and 1 µM, a concentration of tramadol of 10 µM, and concentrations of codeine of 10 µM and 1 µM. Concentrations of morphine of 10 µM and 1 µM showed strong antiangiogenic effects. While codeine had strong antiangiogenic effects at high concentrations, at 0.1 µM it was shown to have weak antiangiogenic effects. However, tramadol at a concentration of 10 µM had only weak antiangiogenic effects. LIMITATIONS This is just a CAM model study. CONCLUSION In this study, we tested the effects of 3 different opioid drugs on angiogenesis in 3 different concentrations, and we observed that morphine was a good anti-angiogenic agent, but tramadol and codeine only had anti-angiogenic effects at high doses.Key Words: Morphine, codeine, tramadol, opioid, bevacizumab, chorioallantoic membrane (CAM), angiogenesis.
Identifying Neural Drivers with Functional MRI: An Electrophysiological Validation

Whether functional magnetic resonance imaging (fMRI) allows the identification of neural drivers remains an open question of particular importance to refine physiological and neuropsychological models of the brain, and/or to understand neurophysiopathology. Here, in a rat model of absence epilepsy showing spontaneous spike-and-wave discharges originating from the first somatosensory cortex (S1BF), we performed simultaneous electroencephalographic (EEG) and fMRI measurements, and subsequent intracerebral EEG (iEEG) recordings in regions strongly activated in fMRI (S1BF, thalamus, and striatum). fMRI connectivity was determined from fMRI time series directly and from hidden state variables using a measure of Granger causality and Dynamic Causal Modelling that relates synaptic activity to fMRI. fMRI connectivity was compared to directed functional coupling estimated from iEEG using asymmetry in generalised synchronisation metrics. The neural driver of spike-and-wave discharges was estimated in S1BF from iEEG, and from fMRI only when hemodynamic effects were explicitly removed. Functional connectivity analysis applied directly on fMRI signals failed because hemodynamics varied between regions, rendering temporal precedence irrelevant. This paper provides the first experimental substantiation of the theoretical possibility to improve interregional coupling estimation from hidden neural states of fMRI. As such, it has important implications for future studies on brain connectivity using functional neuroimaging.