Miracle-dz/UniFAR-FTUs huggingface dataset:
Endoscopic Submucosal Dissection for Early Gastric Cancers with Uncommon Histology

Endoscopic submucosal dissection (ESD) enables en bloc curative resection of early gastric cancers (EGCs) with a negligible risk of lymph node metastasis (LNM). Although ESD for EGCs with absolute and expanded indications is safe, the results differ between EGCs with specialized and common histologies. EGC with papillary adenocarcinoma is a differentiated-type adenocarcinoma. At present, it is treated with ESD according to the same criteria as other differentiated-type adenocarcinomas. The LNM rate under the current indication criteria is high, and over half of the patients who undergo ESD as a primary treatment for EGC with papillary adenocarcinoma achieve an out-of-ESD result. Gastric carcinoma with lymphoid stroma in EGC has a low LNM rate and a favorable outcome, despite deep submucosal invasion. Patients with this gastric cancer subtype may be good candidates for ESD, even with deep submucosal invasion. Large-scale prospective multi-center studies with longer follow-up periods are needed to set proper ESD criteria for these tumors. Clinicians should be aware of these disease entities and ESD should be more carefully considered for EGCs with papillary adenocarcinoma and gastric carcinoma with lymphoid stroma.
‘I Can’t Concentrate’: A Feasibility Study with Young Refugees in Sweden on Developing Science-Driven Interventions for Intrusive Memories Related to Trauma

Background: The number of refugees is the highest ever worldwide. Many have experienced trauma in home countries or on their escape which has mental health sequelae. Intrusive memories comprise distressing scenes of trauma which spring to mind unbidden. Development of novel scalable psychological interventions is needed urgently. Aims: We propose that brief cognitive science-driven interventions should be developed which pinpoint a focal symptom alongside a means to monitor it using behavioural techniques. The aim of the current study was to assess the feasibility and acceptability of the methodology required to develop such an intervention. Method: In this study we recruited 22 refugees (16–25 years), predominantly from Syria and residing in Sweden. Participants were asked to monitor the frequency of intrusive memories of trauma using a daily diary; rate intrusions and concentration; and complete a 1-session behavioural intervention involving Tetris game-play via smartphone. Results: Frequency of intrusive memories was high, and associated with high levels of distress and impaired concentration. Levels of engagement with study procedures were highly promising. Conclusions: The current work opens the way for developing novel cognitive behavioural approaches for traumatized refugees that are mechanistically derived, freely available and internationally scalable.
Frequency Sensitivity Analysis of Load Damping Coefficient in Wind Farm-Integrated Power System

The presence of frequency sensitive loads such as motors has sustainable impact on power system frequency response (SFR). With increasing wind power penetration into the power system, guidelines for frequency regulation need to be revised to ensure system stability and reliability. Frequency regulation becomes more critical with the presence of frequency sensitive loads in wind integrated power system. This paper presents the impact of frequency sensitive loads on system frequency when wind farm is integrated with the conventional power system. A small-signal linearized model of variable speed wind turbine generator is derived. The typical SFR model is developed for wind farm integrated power (WFIP) system. Sensitivity and stability analysis is carried out for linearized model of WFIP system. The observations drawn from the analysis can be useful for the system operators for decision making of appropriate schemes for primary frequency control, demand response, and setting of relays, etc. for secure and stable power system operation. The proposed analysis is validated in IEEE 9-bus system using MATLAB simulation studies.
Serum Levels and Cardiovascular Effects of Tricyclic Antidepressants and Selective Serotonin Reuptake Inhibitors in Depressed Patients

Tricyclic antidepressants (TCAs) and selective serotonin reuptake inhibitors (SSRIs) are used to treat depression. Whereas cardiovascular effects have occasionally been reported during controlled studies with SSRIs, TCA treatment poses a well-known problem in this respect. To investigate the putative correlation between antidepressant dose or serum levels and adverse effects, the authors devised a naturalistic study to evaluate the tricyclic antidepressants' and SSRIs' effect on the cardiovascular system. The authors also compared antidepressant serum levels to adverse effects. Inpatients treated with TCAs or SSRIs were included; an electrocardiogram (ECG) and a Schellong test were carried out on the day patients entered the hospital and during steady-state treatment with antidepressant drugs when blood was drawn for therapeutic drug monitoring. The patient population consisted of 114 acutely depressed patients; 81 patients were treated with TCAs and 33 with SSRIs. The TCAs comprised amitriptyline (n = 43), clomipramine (n = 11), doxepin (n = 19) and imipramine (n = 8); the SSRIs comprised fluvoxamine (n = 14) and paroxetine (n = 19). In TCA-treated patients, the authors observed the same type of abnormalities in conduction and orthostatic hypotension as had been observed earlier. The authors also observed cases of first-degree atrioventricular block, prolonged QTc interval, and orthostatic hypotension in SSRI-treated patients. Thus SSRIs also appear to affect the cardiovascular system, which might pose a problem for patients with preexisting conduction disease. The authors observed a strong correlation between the decrease in systolic pressure and antidepressant serum concentration (except for clomipramine and paroxetine), suggesting that antidepressant serum level is a better correlate than dose.
Antibiotic susceptibility patterns in Rochalimaea quintana, the agent of trench fever

Rochalimaea quintana, the etiological agent of trench fever, was tested by an agar dilution method for its susceptibility to the following 14 antibiotics: penicillin G, methicillin, ampicillin, cephalothin, vancomycin, doxycycline, tetracycline, erythromycin, chloramphenicol, streptomycin, kanamycin, rifampin, colistin, and amphotericin B. The MIC of each of these antibiotics was determined. The results showed that R. quintana is susceptible in vitro to these antibiotics, with the exception of vancomycin, kanamycin, streptomycin, colistin, and amphotericin B.
Elevated Plasma Albumin and Apolipoprotein A-I Oxidation under Suboptimal Specimen Storage Conditions*

S-cysteinylated albumin and methionine-oxidized apolipoprotein A-I (apoA-I) have been posed as candidate markers of diseases associated with oxidative stress. Here, a dilute-and-shoot form of LC–electrospray ionization–MS requiring half a microliter of blood plasma was employed to simultaneously quantify the relative abundance of these oxidized proteoforms in samples stored at −80 °C, −20 °C, and room temperature and exposed to multiple freeze–thaw cycles and other adverse conditions in order to assess the possibility that protein oxidation may occur as a result of poor sample storage or handling. Samples from a healthy donor and a participant with poorly controlled type 2 diabetes started at the same low level of protein oxidation and behaved similarly; significant increases in albumin oxidation via S-cysteinylation were found to occur within hours at room temperature and days at −20 °C. Methionine oxidation of apoA-I took place on a longer time scale, setting in after albumin oxidation reached a plateau. Freeze–thaw cycles had a minimal effect on protein oxidation. In matched collections, protein oxidation in serum was the same as that in plasma. Albumin and apoA-I oxidation were not affected by sample headspace or the degree to which vials were sealed. ApoA-I, however, was unexpectedly found to oxidize faster in samples with lower surface-area-to-volume ratios. An initial survey of samples from patients with inflammatory conditions normally associated with elevated oxidative stress—including acute myocardial infarction and prostate cancer—demonstrated a lack of detectable apoA-I oxidation. Albumin S-cysteinylation in these samples was consistent with known but relatively brief exposures to temperatures above −30 °C (the freezing point of blood plasma). Given their properties and ease of analysis, these oxidized proteoforms, once fully validated, may represent the first markers of blood plasma specimen integrity based on direct measurement of oxidative molecular damage that can occur under suboptimal storage conditions.
A classical instability of Reissner-Nordström solutions and the fate of magnetically charged black holes.

Working in the context of spontaneously broken gauge theories, we show that the magnetically charged Reissner-Nordstrom solution develops a classical instability if the horizon is sufficiently small. This instability has significant implications for the evolution of a magnetically charged black hole. In particular, it leads to the possibility that such a hole could evaporate completely, leaving in its place a nonsingular magnetic monopole.
Nasalseptal hematoma/abscess: management and outcome in a tertiary hospital of a developing country

Background Nasal hematoma/abscess is an uncommon entity, but capable of leading to serious consequences if not handled meticulously, and with urgency. Objective To present the management, and outcome of nasal septal hematoma/abscess in a Nigerian tertiary institution. Method Consecutive patients diagnosed with nasal septal hematoma/abscess over a 10-year period, treated at the University of Nigeria Teaching Hospital, Enugu, Nigeria, were prospectively studied. The processes leading to diagnosis, treatment, and outcome were sequentially evaluated. Results Fifty-three patients (37 males and 16 females), age 5–65 years (with mean age of 23.10 years), were included. Surgical drainage of the hematoma/abscess, intranasal packing with insertion of drain was performed with total resolution of problem in all the cases. Conclusion Incision and drainage, and intranasal packing with insertion of drain was effective in treating nasal septal hematoma/abscess.
Lattice Boltzmann Simulation of Microfluidics with Non-uniform Zeta Potentials: Requirements of Flow Rate and Current Continuities

The characteristics of electrokinetic flow in a microchannel depend on both the nature of the surface potential, i.e. whether it is uniform or nonuniform, and the electric potential distribution along the channel. In this paper, the nonlinear Poisson-Boltzmann equation is used to model the electrical double layer and the Lattice Boltzmann Model coupled with the constraint of current continuity is used to simulate the flow field in a rectangular microchannel with step change surface potential. The results show that step change ion distribution caused by step change surface potential will influence significantly the electric potential distribution along the channel, the velocity profiles and the volumetric flow rate. This may indicate that if disturbance on the ion distribution due to nonuniform surface potential and velocity distortion is large and not negligible, the electric potential distribution along the channel in both pressure-driven and electroosmotic flow may not be linear.
ROWLBAC: representing role based access control in OWL

There have been two parallel themes in access control research in recent years. On the one hand there are efforts to develop new access control models to meet the policy needs of real world application domains. In parallel, and almost separately, researchers have developed policy languages for access control. This paper is motivated by the consideration that these two parallel efforts need to develop synergy. A policy language in the abstract without ties to a model gives the designer little guidance. Conversely a model may not have the machinery to express all the policy details of a given system or may deliberately leave important aspects unspecified. Our vision for the future is a world where advanced access control concepts are embodied in models that are supported by policy languages in a natural intuitive manner, while allowing for details beyond the models to be further specified in the policy language. This paper studies the relationship between the Web Ontology Language (OWL) and the Role Based Access Control (RBAC) model. Although OWL is a web ontology language and not specifically designed for expressing authorization policies, it has been used successfully for this purpose in previous work. OWL is a leading specification language for the Semantic Web, making it a natural vehicle for providing access control in that context. In this paper we show two different ways to support the NIST Standard RBAC model in OWL and then discuss how the OWL constructions can be extended to model attribute-based RBAC or more generally attribute-based access control. We further examine and assess OWL's suitability for two other access control problems: supporting attribute based access control and performing security analysis in a trust-management framework.
Effects of Individual Self-Protection, Industry Self-Regulation, and Government Regulation on Privacy Concerns: A Study of Location-Based Services

T his study seeks to clarify the nature of control in the context of information privacy to generate insights into the effects of different privacy assurance approaches on context-speciﬁc concerns for information privacy. We theorize that such effects are exhibited through mediation by perceived control over personal information and develop arguments in support of the interaction effects involving different privacy assurance approaches (individual self-protection, industry self-regulation, and government legislation). We test the research model in the context of location-based services using data obtained from 178 individuals in Singapore. In general, the results support our core assertion that perceived control over personal information is a key factor affecting context-speciﬁc concerns for information privacy. In addition to enhancing our theoretical understanding of the link between control and privacy concerns, these ﬁndings have important implications for service providers and consumers as well as for regulatory bodies and technology developers.
Depression and Mate Selection During the Transition to Adulthood

There is considerable research demonstrating the link between depression and interpersonal stress. This literature has included support for the phenomenon of stress generation, or the tendency for individuals with depression histories to have higher levels of stress in their lives, particularly interpersonal stressors, even after depression remits. Currently missing from the existing literature, but supported by multiple psychological theories and research on constructs related to depression, is the possibility that individuals prone to depression may self-select into maladaptive romantic partnerships that promote stress and exacerbate depression. The current project sought to explore whether depression portends risk for choosing romantic partners with higher levels of psychopathology or disordered personality traits. This question was explored in two complementary studies. Study 1 utilized a longitudinal, community sample of 252 individuals followed from birth to early adulthood with romantic partners at age 20. Results indicated that individuals with higher levels of depressive symptoms at age 15 had romantic partners by age 20 with higher levels of personality disorder symptoms. Insecure attachment mediated this relationship. Partner personality pathology, in turn, marginally predicted increases in depressive symptoms 2 to 5 years later. Study 2 explored the role of depression in the mate selection process by using a mock online dating laboratory paradigm in which college-aged women rated hypothetical romantic partners based on fabricated dating profiles. Some profiles included antisocial personality disorder traits. Results revealed that current depressive symptoms and major depression history indirectly predicted lower initial interest in antisocial profiles via lower self-esteem and lower perceived similarity to these individuals, respectively. However, when participants were later asked to imagine that an antisocial individual was interested in dating them, depressive symptoms predicted greater positive change in interest in this individual and a greater likelihood of changing an initial refusal to date this individual to a positive response. Findings from both studies indicate that depression plays a role in the mate selection process and can have detrimental consequences. Future research would benefit from further exploring mediators of the relationship between depression and choosing problematic partners and the role of partner characteristics in the cycle of stress and depression.
Neuroprotection by melatonin from kainate‐induced excitotoxicity in rats

In this study, we injected 10 mg/kg kainate i.p. into rats. This resulted in a brain injury, which we quantified in the hippocampus, the amygdala, and the pyriform cortex. Neuronal damage was preceded by a set of typical behavioral signs and by biochemical changes (noradrenaline decrease and 5‐hydroxyindoleacetic acid increase) in the af‐fected brain areas. Melatopin (2.5 mg/kg) was injected i.p. four times: 20 min before kainate, immediately after, and 1 and 2 h after the kainate. The cumulative dose of 10 mg/kg melatonin prevented kainate‐induced neuronal death as well as behavioral and biochemical disturbances. A possible mechanism of melatonin‐provided neuroprotection lies in its antioxidant action. Our results suggest that melatonin holds potential for the treatment of pathologies such as epilepsy‐associated brain damage, stroke, and brain trauma. —Giusti, P., Lipartiti, M. , Franceschini, D. , Schiavo, N. , Floreani, M. , Manev, H. Neuroprotection by melatonin from kainate‐induced excitotoxicity in rats. FASEB J. 10, 891‐896 (1996)
Resveratrol as a novel agent for treatment of multiple myeloma with matrix metalloproteinase inhibitory activity

AbstractAim:To examine the in vitro antitumor activity of resveratrol against multiple myeloma (MM) cell lines (RPMI 8226, U266, and KM3), and the mechanisms involved.Methods:The growth inhibition of resveratrol was determined by 3-(4, 5-dimethyl-2-thiazyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay. The effect of resveratrol on the apoptosis was investigated by combined annexin V-propidium iodide staining. The effect of resveratrol on the invasion through Matrigel matrix was detected by transwell invasion analyses. The activity of matrix metalloproteinase (MMP)-2 and -9 proteins were determined by gelatin zymography analysis. The expression of MMP-2, MMP-9, Bcl-2, Bcl-xL, XIAP and Bax protein were detected using Western blotting analysis.Results:Resveratrol inhibited proliferation of MM cells in a dose- and time-dependent manner. Incubation of MM cells with resveratrol resulted in apoptotic cell death. Resveratrol down-regulated the expression of the antiapoptotic proteins Bcl-2, Bcl-xL and XIAP and up-regulated the expression of the proapoptotic protein Bax. Furthermore, resveratrol inhibited invasion of RPMI 8226, U266, and KM3 cells with IC50 values of 64±8 umol/L, 93±11 umol/L, and 153±11 umol/L, respectively. Resveratrol inhibited the constitutive expression of MMP-2 and -9 proteins of MM cells and suppressed its gelatinolytic activity.Conclusion:Resveratrol inhibits the proliferation of MM cells by inducing apoptotic cell death. Resveratrol also inhibits MM cell invasion. The inhibition of invasion may be associated with the attenuation of the enzymatic activities of MMP-2 and -9.
Diagnostics, Treatment, and Follow-Up in Craniopharyngioma

Craniopharyngiomas are partly cystic embryogenic malformations of the sellar and parasellar region, with up to half the 0.5–2.0 new cases per million population per year occur in children and adolescents. Diagnosis profile for pediatric and adult craniopharyngioma is characterized by a combination of headache, visual impairment, and polyuria/polydipsia, which can also include significant weight gain. In children, growth retardation, and/or premature puberty often occur later or postoperatively. Recommended therapy with favorable tumor localization is complete resection; with unfavorable tumor localization (optic nerve and/or hypothalamic involvement), consensus is still pending whether a limited resection followed by local irradiation is more prudent. Even though overall survival rates are high (92%), recurrences after complete resection and progressions after incomplete resection can be expected. Accordingly, a randomized multinational trial (KRANIOPHARYNGEOM 2007) has been established to identify optimal diagnosis, treatment (particularly the ideal time point of irradiation after incomplete resection), and quality of life strategies of this chronic disease – most notably the morbid hypothalamic obesity in ∼50% of long-term survivors. We report on craniopharyngioma origins, its pathological manifestations, and specific challenges these sequelae pose regarding diagnosis, treatment, and life-long multi-discipline quality of life management for both adult and childhood craniopharyngioma patients.