Miracle-dz/UniFAR-FTUs huggingface dataset:
Controlled pushing of nanoparticles: modeling and experiments

A nano-robotic manipulation system using an atomic force microscope probe as the pushing manipulator and force and topology sensor is proposed. The task is the two-dimensional positioning of nanometer-size particles on a substrate in ambient conditions. Thus, the modeling of interaction forces and dynamics during the pushing operation is analyzed, and compared with the experimental results for an improved understanding of the nano scale physical phenomenon which is different from macro scale physics. Simulations and experiments are held for determining the conditions and strategies for reliable manipulation, and determining the affecting parameters. The results show that the latex particles with 242- and 484-nm radii can be positioned on Si substrates successfully with around 30-nm accuracy, and the behavior of the particle motion during pushing can be predicted from the experimental data.
Design of a Wireless EEG System for Point-of-Care Applications

This study aims to develop a wireless EEG system to provide critical point-of-care information about brain electrical activity. A novel dry electrode, which can be installed rapidly, is used to acquire EEG from the scalp. A wireless data link between the electrode and a data port (i.e., a smartphone) is established based on the Bluetooth technology. A prototype of this system has been implemented and its performance in acquiring EEG has been evaluated.
A Scalable VLSI Architecture for Soft-Input Soft-Output Single Tree-Search Sphere Decoding

Multiple-input multiple-output (MIMO) wireless transmission imposes huge challenges on the design of efficient hardware architectures for iterative receivers. A major challenge is soft-input soft-output (SISO) MIMO demapping, often approached by sphere decoding (SD). In this brief, we introduce-to our best knowledge-the first VLSI architecture for SISO SD applying a single tree-search approach. Compared with a soft-output-only base architecture similar to the one proposed by Studer in IEEE J-SAC 2008, the architectural modifications for soft input still allow a one-node-per-cycle execution. For a 4×4 antennas system using quadrature amplitude modulation (QAM) with order 16, the area increases by 57%, and the operating frequency degrades by 34% only.
Critical success factors and data quality in accounting information systems in Indonesian cooperative enterprises : An empirical examination

Purpose – The purpose of this paper is to test the hypothesis that there is a significant positive relationship between the perceptions of internal auditors about the critical success factors and their perceptions of data quality in accounting information systems (AISs). Design/methodology/approachThe survey method was used to collect data for testing the proposed hyppthesis. Data were collected from internal auditors of cooperatives in Central Sulawesi Province, Indonesia, with 207 responses analysed by standar multiple regression to test the paper’s hypothesis. FindingsThe results indicated that there was a significant positive relationship between the perceptions of internal auditors about the implemention of critical success factors and their perceptions of data quality in AISs. Research limitations/implications – In the field of critical success factors in data quality in AISs, on the basis of ranking the most important factors found that there were six critical success factors in data quality in AISs (top management commitment, middle management commitment, input controls, AIS suitability, teamwork communication and personnel competence). The present study addressed this issue and found that only four of these six ‘critical success factors’ had a positive and significant relationship with data quality in AISs and so can be regarded as critical success factors. Originality/value – The findings provide original evidence that there is a significant positive relationship between critical success factors and data quality in AISs.
A 0.55-V, 28-ppm/°C, 83-nW CMOS Sub-BGR With UltraLow Power Curvature Compensation

This paper proposes an ultralow power, high precision sub bandgap voltage reference (sub-BGR) for low-voltage self-powered devices. A novel ultralow power curvature compensation circuit is proposed to improve the temperature coefficient over a wide temperature range. A switch capacitor voltage divider with improved leakage current reduction switches is used to obtain a high accuracy and a low power. To minimize the clock feedthrough and charge injection in the switches, a clock scaling down circuit is proposed, that effectively improves the line sensitivity (LS) of the sub-BGR. The proposed sub-BGR is implemented in a 0.18-<inline-formula> <tex-math notation="LaTeX">$\mu \text{m}$ </tex-math></inline-formula> standard CMOS process with a total area of 0.061 mm<sup>2</sup>. After measuring 30 chips, the average power consumption is 83 nW at 0.55 V of supply at 27 °C. In the supply voltage range of 0.55 to 1 V, the LS is 0.059%/V, and the error is ±0.75% (<inline-formula> <tex-math notation="LaTeX">$3\sigma $ </tex-math></inline-formula>) after trimming.
The Mitochondrial Na+/Ca2+ Exchanger Upregulates Glucose Dependent Ca2+ Signalling Linked to Insulin Secretion

Mitochondria mediate dual metabolic and Ca2+ shuttling activities. While the former is required for Ca2+ signalling linked to insulin secretion, the role of the latter in β cell function has not been well understood, primarily because the molecular identity of the mitochondrial Ca2+ transporters were elusive and the selectivity of their inhibitors was questionable. This study focuses on NCLX, the recently discovered mitochondrial Na+/Ca2+ exchanger that is linked to Ca2+ signalling in MIN6 and primary β cells. Suppression either of NCLX expression, using a siRNA construct (siNCLX) or of its activity, by a dominant negative construct (dnNCLX), enhanced mitochondrial Ca2+ influx and blocked efflux induced by glucose or by cell depolarization. In addition, NCLX regulated basal, but not glucose-dependent changes, in metabolic rate, mitochondrial membrane potential and mitochondrial resting Ca2+. Importantly, NCLX controlled the rate and amplitude of cytosolic Ca2+ changes induced by depolarization or high glucose, indicating that NCLX is a critical and rate limiting component in the cross talk between mitochondrial and plasma membrane Ca2+ signalling. Finally, knockdown of NCLX expression was followed by a delay in glucose-dependent insulin secretion. These findings suggest that the mitochondrial Na+/Ca2+ exchanger, NCLX, shapes glucose-dependent mitochondrial and cytosolic Ca2+ signals thereby regulating the temporal pattern of insulin secretion in β cells.
Optical transmission on metallic wires-fundamental modes

The surface-plasmon-polaritons supported by a metal stripe are of theoretical and experimental interest. The well-known symmetric and antisymmetric modes of the slab model become the respective fundamental modes of the stripe. Their dispersion and loss characteristics are calculated for a silver stripe embedded in silicon. In contrast to the slab case, higher order modes also occur for the stripe. Corner modes that have no analogous modes in the slab model are obtained. The method of calculation used is a full-vectorial finite difference scheme for the coupled transverse components of the magnetic field.
Effect of Thermal Annealing on the Power Conversion Efficiency of CuO-Bulk Heterojunction P3HT/PC70BM Solar Cells

Abstract In this work, thermal annealing is used to optimize the power conversion efficiency of bulk heterojunction P3HT/PC70BM solar cells synthesized by incorporating copper oxide nanoparticles (CuO NPs). Thermal annealing of P3HT/PC70BM thin films was performed at 150° C for 30 minutes. X-ray diffraction and differential scanning calorimetry analysis show an increase in crystallinity in the heat-treated samples. Atomic force microscopic analysis shows an increase in the surface roughness of the active layer after annealing. The increase in surface roughness seems to have improved the space available for P3HT crystallites to self-organize as the crystallinity of the active layer increased after annealing. Ultraviolet-visible and external quantum efficiency spectra indicate an increase in light absorption and charge carriers in the active layer as the crystallinity of the P3HT/PCBM domain increases. After annealing, the power conversion efficiency of P3HT/PC70BM solar cells incorporated with CuO NPs improved by 30% in comparison to the unannealed polymer solar cells.
Sham acupuncture may be as efficacious as true acupuncture: a systematic review of clinical trials.

OBJECTIVE This study sought to determine whether sham acupuncture is as efficacious as true acupuncture, as defined by traditional acupuncture theories. METHODS A systematic review was conducted of clinical trials that used sham acupuncture controls with needle insertion at wrong points (points not indicated for the condition) or non-points (locations that are not known acupuncture points). This study used a convenience sample of 229 articles resulting from a PubMed search using the keyword "acupuncture" and limited to "clinical trials" published in English in 2005 or 2006. Studies were categorized by use of wrong points versus non-points and the use of normal insertion and stimulation versus superficial insertion or minimal stimulation. RESULTS Thirty-eight acupuncture trials were identified. Most studies (22/38 = 58%) found no statistically significant difference in outcomes, and most of these (13/22 = 59%) found that sham acupuncture may be as efficacious as true acupuncture, especially when superficial needling was applied to non-points. CONCLUSIONS The findings cast doubt on the validity of traditional acupuncture theories about point locations and indications. Scientific rationales for acupuncture trials are needed to define valid controls, and the theoretical basis for traditional acupuncture practice needs to be re-evaluated.
In silico pharmacokinetic and molecular docking studies of small molecules derived from Indigofera aspalathoides Vahl targeting receptor tyrosine kinases

Angiogenesis is the formation of new blood vessels from preexisting vascular network that plays an important role in the tumor growth, invasion and metastasis. Anti-angiogenesis targeting tyrosine kinases such as vascular endothelial growth factor receptor 2 (VEGFR2) and platelet derived growth factor receptor β (PDGFRβ) constitutes a successful target for the treatment of cancer. In this work, molecular docking studies of three bioflavanoid such as indigocarpan, mucronulatol, indigocarpan diacetate and two diterpenes namely erythroxydiol X and Y derived from Indigofera aspalathoides as PDGFRβ and VEGFR2 inhibitors were performed using computational tools. The crystal structures of two target proteins were retrieved from PDB website. Among the five compounds investigated, indigocarpan exhibited potent binding energy ΔG = -7.04 kcal/mol with VEGFR2 and ΔG = -4.82 with PDGFRβ compared to commercially available anti-angiogenic drug sorafenib (positive control). Our results strongly suggested that indigocarpan is a potent angiogenesis inhibitor as ascertained by its potential interaction with VEGFR2 and PDGFRβ. This hypothesis provides a better insight to control metastasis by blocking angiogenesis.
Predicted implications of using percentage weight gain as single discharge criterion in management of acute malnutrition in rural southern Ethiopia.

Mid-upper arm circumference (MUAC) is increasingly used in identifying and admitting children with acute malnutrition for treatment. It is easy to use because it does not involve height assessment, but its use calls for alternative discharge criteria. This study examined how use of percentage weight gain as discharge criterion would affect the nutritional status of children admitted into a community-based management programme for acute malnutrition in rural southern Ethiopia. Non-oedematous children (n = 631) aged 6-59 months and having a MUAC of <125 mm were studied. By simulation, 10%, 15% and 20% weight was added to admission weight and their nutritional status by weight-for-height z-score (WHZ) was determined at each target. Moderate and severe wasting according to World Health Organization WHZ definitions was used as outcome. Applying the most commonly recommended target of 15% weight gain resulted in 9% of children with admission MUAC <115 mm still being moderately or severely wasted at theoretical discharge. In children with admission MUAC 115-124 mm, 10% of weight gain was sufficient to generate a similar result. Children failing to recover were the ones with the poorest nutritional status at admission. Increasing the percentage weight gain targets in the two groups to 20% and 15%, respectively, would largely resolve wasting but likely lead to increased programme costs by keeping already recovered children in the programme. Further research is needed on appropriate discharge procedures in programmes using MUAC for screening and admission.
Responses of Bacterial Communities to Simulated Climate Changes in Alpine Meadow Soil of the Qinghai-Tibet Plateau

ABSTRACT The soil microbial community plays an important role in terrestrial carbon and nitrogen cycling. However, microbial responses to climate warming or cooling remain poorly understood, limiting our ability to predict the consequences of future climate changes. To address this issue, it is critical to identify microbes sensitive to climate change and key driving factors shifting microbial communities. In this study, alpine soil transplant experiments were conducted downward or upward along an elevation gradient between 3,200 and 3,800 m in the Qinghai-Tibet plateau to simulate climate warming or cooling. After a 2-year soil transplant experiment, soil bacterial communities were analyzed by pyrosequencing of 16S rRNA gene amplicons. The results showed that the transplanted soil bacterial communities became more similar to those in their destination sites and more different from those in their “home” sites. Warming led to increases in the relative abundances in Alphaproteobacteria, Gammaproteobacteria, and Actinobacteria and decreases in Acidobacteria, Betaproteobacteria, and Deltaproteobacteria, while cooling had opposite effects on bacterial communities (symmetric response). Soil temperature and plant biomass contributed significantly to shaping the bacterial community structure. Overall, climate warming or cooling shifted the soil bacterial community structure mainly through species sorting, and such a shift might correlate to important biogeochemical processes such as greenhouse gas emissions. This study provides new insights into our understanding of soil bacterial community responses to climate warming and cooling.
Copolymerization of CO2 and 1,2-cyclohexene oxide using a CO2-soluble chromium porphyrin catalyst

The copolymerization of 1,2-cyclohexene oxide (CHO) with carbon dioxide was performed, using supercritical carbon dioxide (scCO2) as both solvent and reactant, to produce an aliphatic polycarbonate. A CO2-soluble catalyst, tetra(pentafluorophenyl)porphyrin chromium(III) chloride (CrTFPPCl), was synthesized and used to catalyze the polymerization in the presence of 4-(dimethylamino)pyridine (DMAP) as cocatalyst. The best yields for the copolymerization (up to ∼75%) were obtained in the temperature range 95−110 °C over a period of 18 h, with a molar ratio of catalyst to monomer of 2.6 × 10-3. High catalyst efficiencies (3.9 kg of polymer/g of Cr) were observed under these conditions. The copolymers consisted predominantly of carbonate linkages (90−97%), and the chain microstructure was analyzed by 1H NMR and 13C NMR spectroscopy. Gel permeation chromatography revealed number-average molecular weights (Mn) of the order of 3500. In contrast to previous studies involving supercritical CO2, narrow polymer molec.
A capacitive micromachined ultrasonic transducer probe for assessment of cortical bone

A wide range of ultrasound methods has been proposed to assess the mechanical strength of bone. The axial transmission technique, which consists of measuring guided elastic modes through the cortical shell of long bones such as the radius or tibia, has recently emerged as one of the most promising approaches of all bone exploration methods. Determination of dispersion curves of guided waves is therefore of prime interest because they provide a large set of input data required to perform inverse process, and hence to evaluate bone properties (elastic and geometric). The cortical thickness of long bones ranges from approximately 1 to 7 mm, resulting in wide inter-individual variability in the guided wave response. This variability can be overcome by using a single probe able to operate with a tunable central frequency, typically within the 100 kHz to 2 MHz frequency range. However, there are certain limitations in the design of low-frequency arrays using traditional PZT technology; these limitations have triggered active research to find alternative solutions. Capacitive micromachined ultrasonic transducers (cMUTs) have the potential to overcome these limitations and to improve axial transmission measurement significantly. The objective of this study was to design and construct a new cMUT-based axial transmission probe and to validate the approach. We report all the steps followed to construct such a prototype, from the description of the fabrication of the cMUT (based on a surface micromachining process) through probe packaging. The fabricated device was carefully characterized using both electrical and optical measurements to check the homogeneity of the device, first from cMUT to cMUT and then from element to element. Finally, axial transmission measurements carried out with the prototype cMUT probe are shown and compared with results obtained with a PZT-based array.
Mechanical Design of Structural Materials in Animals

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Proteomic profile response of Paracoccidioides lutzii to the antifungal argentilactone

The dimorphic fungi Paracoccidioides spp. are the etiological agents of paracoccidioidomycosis (PCM), a mycosis of high incidence in Brazil. The toxicity of drug treatment and the emergence of resistant organisms have led to research for new candidates for drugs. In this study, we demonstrate that the natural product argentilactone was not cytotoxic or genotoxic to MRC5 cells at the IC50 concentration to the fungus. We also verified the proteomic profile of Paracoccidioides lutzii after incubation with argentilactone using a label free quantitative proteome nanoUPLC-MSE. The results of this study indicated that the fungus has a global metabolic adaptation in the presence of argentilactone. Enzymes of important pathways, such as glycolysis, the Krebs cycle and the glyoxylate cycle, were repressed, which drove the metabolism to the methylcytrate cycle and beta-oxidation. Proteins involved in cell rescue, defense and stress response were induced. In this study, alternative metabolic pathways adopted by the fungi were elucidated, helping to elucidate the course of action of the compound studied.
Interaction-Rich Transfer Learning for Collaborative Filtering with Heterogeneous User Feedback

A real recommender system can usually make use of more than one type of user feedback--for example, numerical ratings and binary ratings-to learn a user's true preferences. Recent work has proposed a transfer learning algorithm called transfer by collective factorization (TCF) to exploit such heterogeneous user feedback. TCF performs via sharing data-independent knowledge and modeling data-dependent effects simultaneously. However, TCF is a batch algorithm and updates the model parameters only once after scanning all data, which might not be efficient enough for real systems. This article proposes a novel and efficient transfer learning algorithm called interaction-rich transfer by collective factorization (iTCF), which extends the efficient collective matrix factorization (CMF) algorithm by providing more interactions between the user-specific latent features. The assumption under iTCF is that the predictability with regards to the same user's rating behaviors in two related data is likely to be similar. Considering the shared predictability, the authors derive novel update rules for iTCF in a stochastic algorithmic framework. The advantages of iTCF include its efficiency compared with TCF, and its higher prediction accuracy compared with CMF. Experimental results on three real-world datasets show the effectiveness of iTCF over the state-of-the-art methods.
Familial risk of hepatocellular carcinoma among chronic hepatitis B carriers and their relatives.

BACKGROUND Familial predisposition as a risk factor for hepatocellular carcinoma (HCC) in hepatitis B virus (HBV) carriers has not been thoroughly explored. METHODS The HCC risk associated with having parents and/or siblings with HCC was evaluated by use of a cohort study of 4808 male HBV carriers. A case-control family study was also conducted on data from first-degree relatives of 553 HBV carriers who had newly diagnosed HCC (case subjects) and 4684 HBV carriers without HCC (control subjects). RESULTS In the cohort study, HBV carriers with a family history of HCC had a multivariate-adjusted rate ratio for HCC of 2.41 (95% confidence interval [CI] = 1.47-3.95) compared with HBV carriers without a family history of HCC. For carriers with two or more affected relatives, the ratio increased to 5.55 (95% CI = 2.02-15.26). Cumulative HCC risk by age 70 years was 235.6 per 1000 (95% CI = 95. 3-375.9 per 1000) for HBV carriers with family history compared with 88.9 per 1000 (95% CI = 67.9-109.9 per 1000) for those without. In the case-control family study, first-degree relatives of case subjects were more likely to have HCC (age-sex-adjusted odds ratio [OR] = 2.57; 95% CI = 2.03-3.25) than first-degree relatives of control subjects. The excess risk of HCC among relatives was particularly evident in siblings (sisters-age-adjusted OR = 4.55 [95% CI = 2.22-9.31]; brothers-age-adjusted OR = 3.73 [95% CI = 2. 64-5.27]), but it was also observed in parents. The cumulative risk of HCC to age 80 years was 83.0 per 1000 among relatives of case subjects and 42.0 per 1000 among relatives of control subjects. Among relatives of case subjects, the cumulative risk of HCC was greater if the case subjects were diagnosed before age 50 years (two-sided P =.047). Liver cirrhosis was 2.29 (95% CI = 1.68-3.11) times more frequent in relatives of case subjects than in relatives of control subjects. CONCLUSIONS First-degree relatives of patients with HBV-related HCC appear to be at increased risk of HCC and should be considered in the formulation of HCC-screening programs.