Miracle-dz/UniFAR-FTUs huggingface dataset:
LDSN: Localization scheme for double-head maritime Sensor Networks

Ocean covers nearly 71% of our planet's surface, yet 95% of the ocean remains unexplored by human being, and wireless sensor networks are envisioned to perform monitoring tasks over the large portion of our world. However, deploying wireless sensor networks on the sea poses many challenges and for maritime surveillance security applications we may need to deploy sensors both on the sea surface and underwater for three-dimensional detection. In this paper, we propose a hybrid ocean sensor networks called Double-head maritime Sensor Networks (DSNs), which combine the advantages of wireless sensor networks and underwater acoustic sensor networks. By leveraging the unique characteristics of DSNs, we design a localization scheme LDSN which is consisted of two algorithms SML and FLA. We first use SML to localize moored anchor nodes as seed nodes. After the underwater sensor networks have been localized, the floating double-head nodes can figure out its instant position via FLA algorithm. We evaluate the scheme by simulations and the results show that the scheme can achieve a high localization accuracy.
The Database of Genomic Variants: a curated collection of structural variation in the human genome

Over the past decade, the Database of Genomic Variants (DGV; http://dgv.tcag.ca/) has provided a publicly accessible, comprehensive curated catalogue of structural variation (SV) found in the genomes of control individuals from worldwide populations. Here, we describe updates and new features, which have expanded the utility of DGV for both the basic research and clinical diagnostic communities. The current version of DGV consists of 55 published studies, comprising >2.5 million entries identified in >22 300 genomes. Studies included in DGV are selected from the accessioned data sets in the archival SV databases dbVar (NCBI) and DGVa (EBI), and then further curated for accuracy and validity. The core visualization tool (gbrowse) has been upgraded with additional functions to facilitate data analysis and comparison, and a new query tool has been developed to provide flexible and interactive access to the data. The content from DGV is regularly incorporated into other large-scale genome reference databases and represents a standard data resource for new product and database development, in particular for copy number variation testing in clinical labs. The accurate cataloguing of variants in DGV will continue to enable medical genetics and genome sequencing research.
Low serum total testosterone level as a predictor of upstaging and upgrading in low-risk prostate cancer patients meeting the inclusion criteria for active surveillance

Active surveillance (AS) is currently a widely accepted treatment option for men with clinically localized prostate cancer (PCa). Several reports have highlighted the association of low serum testosterone levels with high-grade, high-stage PCa. However, the impact of serum testosterone as a predictor of progression in men with low-risk PCa has been little assessed. In this study, we evaluated the association of circulating testosterone concentrations with a staging/grading reclassification in a cohort of low-risk PCa patients meeting the inclusion criteria for the AS protocol but opting for radical prostatectomy. Radical prostatectomy (RP) was performed in 338 patients, eligible for AS according to the following criteria: clinical stage T2a or less, PSA<10ng/ml, two or fewer cancer cores, Gleason score (GS)=6 and PSA density<0.2 ng/mL/cc. Reclassification was defined as upstaging (stage>pT2) and upgrading (GS=7; primary Gleason pattern 4) disease. Unfavorable disease was defined as the occurrence of pathological stage>pT2 and predominant Gleason score 4. Total testosterone was measured before surgery. Low serum testosterone levels (<300 ng/dL) were significantly associated with upgrading, upstaging, unfavorable disease and positive surgical margins. The addition of testosterone to a base model, including age, PSA, PSA density, clinical stage and positive cancer involvement in cores, showed a significant independent influence of this variable on upstaging, upgrading and unfavorable disease. In conclusion, our results support the idea that total testosterone should be a selection criterion for inclusion of low-risk PCa patients in AS programs and suggest that testosterone level less than 300 ng/dL should be considered a discouraging factor when a close AS program is considered as treatment option
Structural Integrity of the Prefrontal Cortex Modulates Electrocortical Sensitivity to Reward

The P300 is a known ERP component assessing stimulus value, including the value of a monetary reward. In parallel, the incentive value of reinforcers relies on the PFC, a major cortical projection region of the mesocortical reward pathway. Here we show a significant positive correlation between P300 response to money (vs. no money) with PFC gray matter volume in the OFC, ACC, and dorsolateral and ventrolateral PFC in healthy control participants. In contrast, individuals with cocaine use disorders showed compromises in both P300 sensitivity to money and PFC gray matter volume in the ventrolateral PFC and OFC and their interdependence. These results document for the first time the importance of gray matter structural integrity of subregions of PFC to the reward-modulated P300 response.
The effects of Agaricus sylvaticus fungi dietary supplementation on the metabolism and blood pressure of patients with colorectal cancer during post surgical phase

Introduction: Metabolic, biochemical and enzymatic alterations are common in patients with cancer. Medicinal fungi has been used as adjuvants in cancer therapy due to its immunomodulatory and nutritional effects. Objective: The objective of this study was to evaluate the metabolic and blood pressure effects on patients with colorectal cancer after dietary supplementation with Agaricus sylvaticus. Methods: The methodology used was a randomized, double-blind, placebo-controlled clinical trial conducted at the Base Hospital of the Federal District-Brazil. Samples of 56 patients with colorectal cancer, divided into two groups: Agaricus sylvaticus (30 mg/kg/day) and placebo. Three serum evaluations were conducted throughout the treatment: glucose, total cholesterol, triglycerides, uric acid, urea, creatinine, alkaline phosphatase; total, direct and indirect bilirubin; aspartate aminotransferase and alanine aminotransferase; immunoglobulins A (IgA), G (IgG) and M (IgM); total proteins and protein fractions; blood pressure levels were measured as well. The results were analyzed by Microsoft Excel 2003 and SPSS 14.0 programs, Student’s t test, F statistical test, with p ≤ 0.05. Results: The Agaricus sylvaticus group presented a significant reduction of fasting plasma glucose (p = 0.02), total cholesterol (p = 0.01), creatinine (p = 0.05), aspartate aminotransferase (p = 0.05), alanine aminotransferase (p = 0.04), IgA (p = 0.0001), IgM (p = 0.02), systolic blood pressure (p = 0.0001)and diastolic blood pressure (p = 0.0001). These alterations were not observed in the placebo group. Conclusions: Results suggest that dietary supplementation with Agaricus sylvaticus is capable of providing metabolic benefits to the biochemical, enzymatic and blood pressure parameters of patients with colorectal cancer in the postsurgical phase. (Nutr Hosp. 2011;26:176-186) DOI:10.3305/nh.2011. 26.1. 4129
Prediction Errors Drive UCS Revaluation and not Classical Conditioning: Evidence and Neurophysiological Consequences

Nowadays, the experimental study of emotional learning is commonly based on classical conditioning paradigms and models, which have been thoroughly investigated in the last century. On the contrary, limited attention has been paid to the revaluation of an unconditioned stimulus (UCS), which, as experimentally observed by various researchers in the last four decades, occurs out of classical conditioning. For this reason, no analytical or quantitative theory has been developed for this phenomenon and its dynamics. Unluckily, models based on classical conditioning are unable to explain or predict important psychophysiological phenomena, such as the failure of the extinction of emotional responses in certain circumstances. In this manuscript an analytical representation of UCS revaluation learning is developed; this allows us to identify the conditions determining the "inextinguishability" (or resistant-to-extinction) property of emotional responses and reactions (such as those observed in evaluative conditioning, in the nonreinforcement presentation of a conditioned inhibitor, in post-traumatic stress disorders and in panic attacks). Furthermore, an analysis of the causal relation existing between classical conditioning and UCS revaluation is provided. Starting from this result, a theory of implicit emotional learning and a novel interpretation of classical conditioning are derived. Moreover, we discuss how the proposed theory can lead to the development of new methodologies for the detection and the treatment of undesired or pathological emotional responses, and can inspire animal models for resistant-to-extinction responses and reactions.
EFEKTIVIS KEGIATAN LESSON STUDY DALAM MERANCANG PEMBELAJARAN PADA MATA KULIAH GELOMBANG DAN OPTIK

Lesson study has been conducted as a strategy to improve the processes and outcomes of learning, this activity implemented in a collaborative and sustained by a group of lecturer (lecturer models and observers). The main objectives of lesson study activities namely to gain a better understanding of how students learn and lecturers teach, designing learning that is easily understood by students in each of the learning process and buil a pedagogical knowledge, where a lectureria able to gain knowledge from other lecturer. This activity is conducted for four stages during one semester and this is conducted in stages. Each stage consists of planning (plan), observation (do) and reflection (see). Lesson this lesson study is expected to provide lessons and learning experinces of students in general and in particular the lecturer models and able to build cooperative contextual learning. From a series of stages that have been done can be concluded that the need for cooperation in designing an effective learning, maximum and sustainable. Telah dilakukan kegiatan lesson study yang merupakan strategi untuk meningkatkan proses dan hasil pembelajaran yang dilaksanakan secara kolaboratif dan berkelanjutan oleh sekelompok dosen (dosen model dan dosen observer). Tujuan utama kegiatan lesson study yaitu memperoleh pemahaman yang lebih baik tentang bagaimana mahasiswa belajar dan dosen mengajar, merancang pembelajaran yang mudah dipahami oleh mahasiswa dalam setiap proses pembelajaran serta membangun sebuah pengetahuan pedagogis, dimana seorang dosen mampu menimba pengetahuan dari dosen lain. Kegiatan dilakukan selama empat siklus selama satu semester yang dilakukan secara bertahap. Setiap tahapan terdiri dari perencanaan ( plan ), observasi ( do ) dan refleksi ( see ). Pembelajaran ini diharapakan mampu membelajarkan mahasiswa pada umumnya dan dosen model pada khususnya dan mampu membangun pembelajaran kontekstual yang kooperatif. Dari serangkaian siklus yang dilakukan dapat simpulkan bahwa perlu kerjasama dalam merancang sebuah pembelajaran yang efektif, maksimal dan berkelanjutan Kata kunci: do, lesson study, plan, see
Usefulness of vonoprazan, a potassium ion-competitive acid blocker, for primary eradication of Helicobacter pylori

AIM To investigate usefulness of triple therapy with vonoprazan, a potassium ion-competitive acid blocker and antibiotics, for Helicobacter pylori (H. pylori) eradication. METHODS The H. pylori eradication rate was examined in 2507 patients (2055 undergoing primary eradication and 452 undergoing secondary eradication, excluding patients with subtotal gastrectomy) at the Japanese Red Cross Kyoto Daiichi Hospital from March 2013 to September 2015. For patients treated from March 2013 to February 2015, a proton pump inhibitor (PPI) was used to reduce acid secretion, while vonoprazan was used after March 2015. The success rates of the 2 regimens (PPI + amoxicillin + clarithromycin/metronidazole, or vonoprazan + amoxicillin + clarithromycin/metronidazole) were compared. RESULTS The success rate of primary H. pylori eradication was significantly higher in the vonoprazan group. When stratified by the underlying disease, a significant increase of the H. pylori eradication rate was observed in patients with chronic gastritis. A significantly lower H. pylori eradication rate was observed in younger patients compared to older patients in the PPI group, but there was no difference according to age in the vonoprazan group. On the other hand, the success rate of secondary eradication was similar at approximately 90% in both groups. CONCLUSION Vonoprazan is very useful for primary eradication of H. pylori, and may become a first-line acid secretion inhibitor instead of PPIs.
High Speed Atomic Force Microscopy Visualizes Processive Movement of Trichoderma reesei Cellobiohydrolase I on Crystalline Cellulose*

Fungal cellobiohydrolases act at liquid-solid interfaces. They have the ability to hydrolyze cellulose chains of a crystalline substrate because of their two-domain structure, i.e. cellulose-binding domain and catalytic domain, and unique active site architecture. However, the details of the action of the two domains on crystalline cellulose are still unclear. Here, we present real time observations of Trichoderma reesei (Tr) cellobiohydrolase I (Cel7A) molecules sliding on crystalline cellulose, obtained with a high speed atomic force microscope. The average velocity of the sliding movement on crystalline cellulose was 3.5 nm/s, and interestingly, the catalytic domain without the cellulose-binding domain moved with a velocity similar to that of the intact TrCel7A enzyme. However, no sliding of a catalytically inactive enzyme (mutant E212Q) or a variant lacking tryptophan at the entrance of the active site tunnel (mutant W40A) could be detected. This indicates that, besides the hydrolysis of glycosidic bonds, the loading of a cellulose chain into the active site tunnel is also essential for the enzyme movement.
Reporting on selective voices of ‘resistance’: Secularism, class and ‘Islamist’ rap

Since the 2010–11 popular uprisings that swept the Middle East and North Africa (MENA), rap music has served commentators to channel stories of disenfranchisement and oppression among the region’s youth. Accounts that portray rappers as significant political actors, however, reproduce narratives of ‘resistance’ that focus on opposition to governance but overlook social inequalities. Further, the case studies of two Moroccan rappers illustrate that commentators value criticisms of social inequalities as long as they are not framed with a religious ethos. Terms such as Islamist rap serve to discredit dissent, proving that when it comes to reporting on Moroccan rap, journalists and academics disregard local expressions of grievance more related to class issues than to modes of governance. Through discourse analysis, open-ended interviews and ethnography (2011–15), this article argues for the urgency of listening to important voices of social and political dissent silenced due to a disregard for class biases.
Microanisotropy imaging: quantification of microscopic diffusion anisotropy and orientational order parameter by diffusion MRI with magic-angle spinning of the q-vector

Diffusion tensor imaging (DTI) is the method of choice for non-invasive investigations of the structure of human brain white matter. The results are conventionally reported as maps of the fractional anisotropy (FA), which is a parameter related to microstructural features such as axon density, diameter, and myelination. The interpretation of FA in terms of microstructure becomes ambiguous when there is a distribution of axon orientations within the image voxel. In this paper, we propose a procedure for resolving this ambiguity by determining a new parameter, the microscopic fractional anisotropy (µFA), which corresponds to the FA without the confounding influence of orientation dispersion. In addition, we suggest a method for measuring the orientational order parameter (OP) for the anisotropic objects. The experimental protocol is capitalizing on a recently developed diffusion NMR pulse sequence based on magic-angle spinning of the q-vector. Proof-of-principle experiments are carried out on microimaging and clinical MRI equipment using lyotropic liquid crystals and plant tissues as model materials with high µFA and low FA on account of orientation dispersion. We expect the presented method to be especially fruitful in combination with DTI and high angular resolution acquisition protocols for neuroimaging studies of grey and white matter.
Universal compensation -- an approach to noisy speech recognition assuming no knowledge of noise

We aim to develop an acoustic model for noisy speech recognition that is "trained once, suits all", in terms of offering a recognition performance close to the matched training-testing condition performance based only on clean speech training data. This paper describes such a method termed universal compensation (UC), for its ability to accommodate arbitrary additive noise without assuming any knowledge about the noise. The new UC method consists of two parts: 1) converting full-band spectral corruption into partial-band spectral corruption through compensations for simulated wide-band flat-spectrum noise at consecutive SNRs (signal-to-noise ratios); and 2) reducing the effect of the remaining partial frequency-band corruption on recognition by ignoring the severely mismatched spectral components and basing the recognition mainly on the matched or appropriately compensated spectral components. Experiments on Aurora 2 indicate that the new model, trained from clean data, has achieved a performance comparable to the performance obtained by the baseline system trained on multi-condition data; experiments with noises unseen in Aurora 2 have shown significant improvement for the new model over the baseline model with multi-condition training.
SUB OPTIMAL CONTROL OF SWITCHED NONLINEAR SYSTEMS UNDER LOCATION AND SWITCHING CONSTRAINTS

Abstract This paper considers an optimal control problem for switched nonlinear systems. The objective is to minimize an associated cost functional, by finding an appropriate continuous control input and location switching strategy. We propose an extension of an algorithm based on strong variations to handle constraints on both locations and switching instants. Numerical experiments testify the viability and the tractability of such a scheme.
Toxicity of Nano-Zero Valent Iron to Freshwater and Marine Organisms

We tested whether three commercial forms (uncoated, organic coating, and iron oxide coating) of nano zero-valent iron (nZVI) are toxic to freshwater and marine organisms, specifically three species of marine phytoplankton, one species of freshwater phytoplankton, and a freshwater zooplankton species (Daphnia magna), because these organisms may be exposed downstream of where nZVI is applied to remediate polluted soil. The aggregation and reactivity of the three types of nZVI varied considerably, which was reflected in their toxicity. Since levels of Fe2+ and Fe3+ increase as the nZVI react, we also evaluated their toxicity independently. All four phytoplankton species displayed decreasing population growth rates, and Daphnia magna showed increasing mortality, in response to increasing levels of nZVI, and to a lesser degree with increasing Fe2+ and Fe3+. All forms of nZVI aggregated in soil and water, especially in the presence of a high concentration of calcium ions in groundwater, thus reducing their transports through the environment. However, uncoated nZVI aggregated extremely rapidly, thus vastly reducing the probability of environmental transport and potential for toxicity. This information can be used to design a risk management strategy to arrest the transport of injected nZVI beyond the intended remediation area, by injecting inert calcium salts as a barrier to transport.
Dynamic training volume: a construct of both time under tension and volume load.

The purpose of this study was to investigate the effects of three different weight training protocols, that varied in the way training volume was measured, on acute muscular fatigue. Ten resistance-trained males performed all three protocols which involved dynamic constant resistance exercise of the elbow flexors. Protocol A provided a standard for the time the muscle group was under tension (TUT) and volume load (VL), expressed as the product of the total number of repetitions and the load that was lifted. Protocol B involved 40% of the TUT but the same VL compared to protocol A; protocol C was equated with protocol A for TUT but only involved 50% of the VL. Fatigue was assessed by changes in maximum voluntary isometric force and integrated electromyography (iEMG) between the pre- and post-training protocols. The results of the study showed that, when equated for VL, greater TUT produced greater overall muscular fatigue (p ≤ 0.001) as reflected by the reduction in the force generating capability of the muscle. When the protocols were equated for TUT, greater VL (p ≤ 0.01) resulted in greater overall muscular fatigue. All three protocols resulted in significant decreases in iEMG (p ≤ 0.05) but they were not significantly different from each other. It was concluded that, because of the importance of training volume to neuromuscular adaptation, the training volume needs to be clearly described when designing resistance training programs. Key PointsIncrease in either time under tension (TUT) or volume load (VL) increases the acute fatigue response, despite being equated for volume (by another method). A potential discrepancy in training volume may be present with training parameters that fail to control for either TUT or VL.Neural fatigue may be a contributing factor to the development of muscular fatigue but is not influenced by various methods of calculating volume such as TUT or VL.
Civil Society and Party Politics in Bulgaria after 2013: A Gramscian Look

In 2013, Bulgaria was shaken by two waves of mass protests, which seemed to mobilise distinct social groups and put different, and often conflicting, demands on the table. In the midst of the turbulence of the protests, new political formations emerged which aimed to capitalise on the mobilisations. The mushrooming of new political projects in the wake of the mass protests seems to mark an apparent re-politicisation following the post-political turn after 1989. Yet the language and identities of these new civic and party formations point to a more complicated dynamic between civic movements, political parties and the state. Drawing on Gramsci’s theory of hegemony, this article scrutinises the links between the newly emerged political projects and the civic mobilisations of 2013 to unravel the new social cleavages underpinning them and consider how these are played out in a context of a changed relationship between civil society and party politics 25 years after the fall of the socialist regime in Bulgaria.
Emotionally controlled Virtual Environments: A New Tool for Enhancing Presence through Media Content Manipulation

A participantssense of "being there" in a mediated experience is determined by a variety of characteristics or components. The EMMA Project (IST-2001-39192) is interested in analyzing the relationships between presence and emotions, especially for some Virtual Reality applications, such as mental health (both for promotion and treatment goals). This research will help to understand better the development of some psychopathological phenomena and the development of new correcting experiences and learning to cope with those psychopathological experiences. Mood devices are special hardware and software configurations able to induce different forms of mood enhancement. In this paper, we describe one of the "mood devices" that have been developed inside the project: the EMMA room.