Miracle-dz/UniFAR-FTUs huggingface dataset:
Systemic elastin degradation in chronic obstructive pulmonary disease

Background Development of emphysema and vascular stiffness in chronic obstructive pulmonary disease (COPD) may be due to a common mechanism of susceptibility to pulmonary and systemic elastin degradation. Objectives To investigate whether patients with COPD have evidence of systemic elastin degradation in the skin. Methods The authors measured cutaneous elastin degradation using immunohistochemistry (percentage area of elastin fibres) in sun-exposed (exposed) and non-sun-exposed (non-exposed) skin biopsies in 16 men with COPD and 15 controls matched for age and cigarette smoke exposure. Quantitative PCR of matrix metalloproteinase (MMP)-2, -9, -12 and tissue inhibitor of metalloproteinase-1 mRNA and zymography for protein expression of MMP-2 and -9 were performed on homogenised skin. Arterial stiffness and emphysema severity were measured using carotid-femoral pulse wave velocity and quantitative CT scanning. Results Skin elastin degradation was greater in exposed and non-exposed skin of patients with COPD compared with controls (exposed, mean (SD); 43.5 (12.1)% vs 26.3 (6.9)%, p<0.001; non-exposed 22.4 (5.2)% vs 18.1 (4.3)%, p=0.02). Cutaneous expression of MMP-9 mRNA and proMMP-9 concentrations was increased in exposed skin of COPD patients (p=0.004 and p=0.02, respectively) and was also associated with increased skin elastin degradation (r=0.62, p<0.001 and r=0.47, p=0.01, respectively). In the entire cohort of ex-smokers, cutaneous elastin degradation was associated with emphysema severity, FEV1 and pulse wave velocity. Conclusions Patients with COPD have increased skin elastin degradation compared with controls, which is related to emphysema severity and arterial stiffness. Systemic elastin degradation due to increased proteolytic activity may represent a novel shared mechanism for the pulmonary, vascular and cutaneous features of COPD.
Combined Subband-Subcarrier Spectral Shaping in Multi-Carrier Modulation Under the Excess Frame Length Constraint

This paper investigates spectral shaping of multi-carrier-modulation waveforms based on combination of Nyquist windowing and subband filtering. The combined windowing/filtering allows simultaneous control on both subcarrier and subband spectra. When compared with the existing Nyquist windowing or subband filtering techniques under a fixed excess frame length constraint, the proposed scheme offers reduced sensitivity to carrier frequency and symbol timing offsets. Establishing an analytical tool based on the error spectrum stack consisting of the error signals evaluated at different signal delay positions, we explore the window-filter trade-off and provide the minimum interference power solution for given ranges of carrier frequency and symbol timing offsets. Our design targets low-latency applications having no provisions for high-precision synchronization and having potential need for spectrum aggregation.
Political efficacy and electoral participation of Chicago Latinos

To explore feelings of political efficacy among Chicago Latinos, making intraethnic comparisons within the Chicago Latino community as well as comparisons to blacks and Anglos using NES data. Analysis of my spring 1997 telephone survey of Chicago Latinos about their feelings of political efficacy and their voting behavior in the 1996 general elections. Chicago Latinos report lower feelings of political efficacy on an internal efficacy item and on one of two external efficacy items than do most national groups, but much higher levels of external efficacy on the remaining item. There are also interesting differences in responses among groups within the Chicago Latino community. Also, Chicago Latinos do not exhibit the same link between external efficacy and voting as has been found for Anglos. Chicago Latinos feel that their political reality is one of relatively high empowerment, and they tend to view voting as more of a symbolic act than as an instrumental one
The Role of Ligand Exchange in the Uptake of Iron from Microbial Siderophores by Gramineous Plants

The siderophore rhizoferrin, produced by the fungus Rhizopus arrhizus, was previously found to be as an efficient Fe source as Fe-ethylenediamine-di(o-hydroxphenylacetic acid) to strategy I plants. The role of this microbial siderophore in Fe uptake by strategy II plants is the focus of this research. Fe-rhizoferrin was found to be an efficient Fe source for barley (Hordeum vulgare L.) and corn (Zea mays L.). The mechanisms by which these Gramineae utilize Fe from Fe-rhizoferrin and from other chelators were studied. Fe uptake from 59Fe-rhizoferrin, 59Fe-ferrioxamine B, 59Fe-ethylenediaminetetraacetic acid, and 59Fe-2[prime]-deoxymugineic acid by barley plants grown in nutrient solution at pH 6.0 was examined during periods of high (morning) and low (evening) phytosiderophore release. Uptake and translocation rates from Fe chelates paralleled the diurnal rhythm of phytosiderophore release. In corn, however, similar uptake and translocation rates were observed both in the morning and in the evening. A constant rate of the phytosiderophore's release during 14 h of light was found in the corn cv Alice. The results presented support the hypothesis that Fe from Fe-rhizoferrin is taken up by strategy II plants via an indirect mechanism that involves ligand exchange between the ferrated microbial siderophore and phytosiderophores, which are then taken up by the plant. This hypothesis was verified by in vitro ligand-exchange experiments.
First pregnancy characteristics and subsequent breast cancer risk among young women

There is growing evidence that perinatal factors associated with altered gestational hormones may influence subsequent breast cancer risk in the mother. Events occurring during the first pregnancy may be particularly important. In this matched case‐control study, we investigated the relation between characteristics of a woman's first pregnancy and her later breast cancer risk using linked records from the New York State birth and tumor registries. Cases were 2,522 women aged 22 to 55 diagnosed with breast cancer between 1978 and 1995 and who had also completed a first pregnancy in New York State (NY) at least 1 year prior to diagnosis. Controls were 10,052 primiparous women not diagnosed with breast or endometrial cancer in NY and matched to cases on county of residence and date of delivery. Information on factors characterizing the woman's first pregnancy was obtained from the pregnancy record of each subject. The association of these factors to breast cancer risk was assessed using conditional logistic regression. Extreme prematurity (< 32 weeks gestational age) was associated with elevated maternal breast cancer risk [adjusted odds ratio (OR)=2.1, 95% confidence interval (CI) 1.2,3.9], as were abruptio placentae (OR = 1.8, CI 1.1,3.0) and multifetal gestation (OR=1.8, CI 1.1,3.0). Preeclampsia was associated with a marked reduction in breast cancer risk among women who bore their first child after age 30 (OR=0.3, CI 0.2,0.7) and in the first 3 years after delivery (OR=0.2 (0.1–0.9). These findings suggest that certain perinatal factors influence maternal breast cancer risk and offer indirect support for a role of gestational hormones, and particularly gestational estrogens, in the etiology of breast cancer. © 2004 Wiley‐Liss, Inc.
Matter with dilaton charge in Weyl–Cartan spacetime and evolution of the universe

The perfect dilaton? spin fluid (as a model of the dilaton matter, the particles of which are endowed with intrinsic spin and dilaton charge) is considered as the source of the gravitational field in a Weyl? Cartan spacetime. The variational formalism of the gravitational field in a Weyl? Cartan spacetime is developed in the exterior form language. A homogeneous and isotropic universe filled with the dilaton matter as the dark matter is considered and one of the field equations is represented as the Einstein-like equation which leads to the modified Friedmann? Lema? tre equation. From this equation the absence of the initial singularity in the cosmological solution follows. Also the existence of two points of inflection of the scale factor function is established, the first of which corresponds to the early stage of the universe and the second to the modern era when the expansion with deceleration is replaced by the expansion with acceleration. Possible equations of state for the self-interacting cold dark matter are found on the basis of the modern observational data. An inflation-like solution is obtained.
Electoral Rules and Minority Representation in U.S. Cities

This paper studies the choice of electoral rules and in particular the question of minority representation. Majorities tend to disenfranchise minorities through strategic manipulation of electoral rules. With the aim of explaining changes in electoral rules adopted by U.S. cities, particularly in the South, we show why majorities tend to adopt "winner-take-all" city-wide rules (at-large elections) in response to an increase in the size of the minority when the minority they are facing is relatively small. In this case, for the majority it is more effective to leverage on its sheer size instead of risking conceding representation to voters from minority-elected districts. However, as the minority becomes larger (closer to a fifty-fifty split), the possibility of losing the whole city induces the majority to prefer minority votes to be confined in minority-packed districts. Single-member district rules serve this purpose. We show empirical results consistent with these implications of the model in a novel data set covering U.S. cities and towns from 1930 to 2000.
Complexity of Motor Sequences and Cortical Reorganization in Parkinson's Disease: A Functional MRI Study

Motor impairment is the most relevant clinical feature in Parkinson's disease (PD). Functional imaging studies on motor impairment in PD have revealed changes in the cortical motor circuits, with particular involvement of the fronto-striatal network. The aim of this study was to assess brain activations during the performance of three different motor exercises, characterized by progressive complexity, using a functional fMRI multiple block paradigm, in PD patients and matched control subjects. Unlike from single-task comparisons, multi-task comparisons between similar exercises allowed to analyse brain areas involved in motor complexity planning and execution. Our results showed that in the single-task comparisons the involvement of primary and secondary motor areas was observed, consistent with previous findings based on similar paradigms. Most notably, in the multi-task comparisons a greater activation of supplementary motor area and posterior parietal cortex in PD patients, compared with controls, was observed. Furthermore, PD patients, compared with controls, had a lower activation of the basal ganglia and limbic structures, presumably leading to the impairment in the higher levels of motor control, including complexity planning and execution. The findings suggest that in PD patients occur both compensatory mechanisms and loss of efficiency and provide further insight into the pathophysiological role of distinct cortical and subcortical areas in motor dysfunction.
The Role of Chinese Face in the Perpetration of Dating Partner Violence

This study explored the associations between the perpetration of partner violence and two types of face orientation—protective and acquisitive—in Chinese societies. Data from a convenience sample of 3,388 university students from Hong Kong, Shanghai, and Beijing were analyzed. The participants completed the Protective and Acquisitive Face Orientation (PAFO) Scale Short Form and the Revised Conflict Tactics Scale (CTS2) to measure their face orientations and experience of perpetrating violence against their dating partner. Acquisitive face orientation (AFO) was positively associated with the self-reported perpetration of physical and psychological partner violence. No significant associations were found between protective face orientation (PFO) and partner violence perpetration. Gender differences were found across all types of dating violence. City of residence, age, and SES were also associated with partner violence in specific ways. The findings gave insights on the possible mechanisms between partner violence and the concept of face to be explored in future research.
Clinical outcomes after carotid endarterectomy: comparison of the use of regional and general anesthetics.

OBJECT The authors analyzed their series of carotid endarterectomies (CEAs), which were performed after administration of either a general or regional anesthetic, to determine whether the choice of anesthetic affected patients' clinical outcomes and length of hospital stay. METHODS A series of 803 consecutive CEAs performed between July 1990 and February 1999 was reviewed. Cases were analyzed for patient demographics, comorbid medical states, and perioperative complications. Contingency-table statistical analysis was used to compare the incidence of comorbid medical states and perioperative complications between patients who underwent CEA in which either a regional or general anesthetic was used. Student's t-test was used to compare the length of hospital stay and mean patient age. A regional anesthetic was used for 632 CEAs, and a general anesthetic was used for 171 operations. There were no statistically significant intergroup differences in demographics or comorbid medical states. The incidence of perioperative stroke and death did not differ significantly between the regional (2.7%) and the general anesthetic groups (2.3%). However, the incidence of nonneurological, nonfatal complications was significantly less in the regional anesthetic (1.6%) than in the general anesthetic group (14.6%, p<0.0001). Patients undergoing CEA in which a regional anesthetic was used had a significantly lower incidence of cardiopulmonary complications (myocardial infarction and postoperative intubation), cervical complications (neck hematomas and cranial nerve injuries), and urological complications (urinary retention) than patients who underwent surgery after receiving a general anesthetic. CONCLUSIONS Patients undergoing CEA in which a regional anesthetic was used had significantly fewer nonneurological, nonfatal complications, particularly cardiopulmonary complications, than similar patients surgically treated after induction of general anesthesia.
The knowledge integration strategy analysis after Geely acquisition of Volvo

Post-merger integration is not only concern the integration of tangible assets, but should focus on knowledge integration. After the M&A, to absorb the knowledge of merged corporation should be given priority to, then to create new knowledge on this basis by integrating the existing knowledge. By analysisng the case that Geely's acquisition of Volvo, The paper aims to explore the strategy to improve the performance of knowledge integration after enterprise merger.
On the treatment and prognosis of malignant ascites: Is the survival time determined when the abdominal paracentesis is needed?

We review a series of 100 consecutive cases of malignancy treated for as cites with abdominal paracentesis. The results of treatment for ascites with intracavitary Thiotepa are reported for 23 patients. The temporary partial response rate was 8/23 (35%) patients. There were symptoms of intestinal obstruction in five patients (22%) treated with Thiotepa, and one of these patients died of intestinal obstruction. In 60% of autopsied patients there were abundant intestinal adhesions in the peritoneal cavity after Thiotepa. We concluded that Thiotepa is contraindicated for instillation into the peritoneal cavity. The median survival time for patients with carcinoma of the mammary gland was 47 days, carcinoma of the ovary 121 days, and carcinoma of the large intestine 54 days after the first abdominal paracentesis. We found that patients without clinical liver metastasis at the time of first abdominal paracentesis had almost three times longer median survival time than that of patients with metastatic liver. In four cases the immediate cause of death was a complication of an abdominal paracentesis.
What a Nerd! Beating Students and Vector Cosine in the ESL and TOEFL Datasets

In this paper, we claim that Vector Cosine ― which is generally considered one of the most efficient unsupervised measures for identifying word similarity in Vector Space Models ― can be outperformed by a completely unsupervised measure that evaluates the extent of the intersection among the most associated contexts of two target words, weighting such intersection according to the rank of the shared contexts in the dependency ranked lists. This claim comes from the hypothesis that similar words do not simply occur in similar contexts, but they share a larger portion of their most relevant contexts compared to other related words. To prove it, we describe and evaluate APSyn, a variant of Average Precision that ― independently of the adopted parameters ― outperforms the Vector Cosine and the co-occurrence on the ESL and TOEFL test sets. In the best setting, APSyn reaches 0.73 accuracy on the ESL dataset and 0.70 accuracy in the TOEFL dataset, beating therefore the non-English US college applicants (whose average, as reported in the literature, is 64.50%) and several state-of-the-art approaches.
Activation of ATP-sensitive K+ (KATP) channels by H2O2 underlies glutamate-dependent inhibition of striatal dopamine release

In many cells, ATP-sensitive K+ channels (KATP channels) couple metabolic state to excitability. In pancreatic beta cells, for example, this coupling regulates insulin release. Although KATP channels are abundantly expressed in the brain, their physiological role and the factors that regulate them are poorly understood. One potential regulator is H2O2. We reported previously that dopamine (DA) release in the striatum is modulated by endogenous H2O2, generated downstream from glutamatergic α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-receptor activation. Here we investigated whether H2O2-sensitive KATP channels contribute to DA-release modulation by glutamate and γ-aminobutyric acid (GABA). This question is important because DA–glutamate interactions underlie brain functions, including motor control and cognition. Synaptic DA release was evoked by using local electrical stimulation in slices of guinea pig striatum and monitored in real time with carbon-fiber microelectrodes and fast-scan cyclic voltammetry. The KATP-channel antagonist glibenclamide abolished the H2O2-dependent increase in DA release usually seen with AMPA-receptor blockade by GYKI-52466 [1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride] and the decrease in DA release seen with GABA-type-A-receptor blockade by picrotoxin. In contrast, 5-hydroxydecanoate, a mitochondrial KATP-channel blocker, was ineffective, as were sulpiride, a D2-receptor antagonist, and tertiapin, a G protein-coupled K+-channel inhibitor. Diazoxide, a sulfonylurea receptor 1 (SUR1)selective KATP-channel opener, prevented DA modulation by H2O2, glutamate, and GABA, whereas cromakalim, a SUR2-selective opener, did not. Thus, endogenous H2O2 activates SUR1-containing KATP channels in the plasma membrane to inhibit DA release. These data not only demonstrate that KATP channels can modulate CNS transmitter release in response to fast-synaptic transmission but also introduce H2O2 as a KATP-channel regulator.
Misremembering the Appearance of Common Objects: Further Cross-Cultural Confirmation

The finding that people have surprisingly poor memory for the details of commonly used coins was replicated using a heretofore unstudied currency (the Irish Punt). The accuracy of 241 undergraduates in psychology in identifying a true coin from among a selection of similar fakes was low (41.9%), in line with findings from several other countries.
Complexity analysis of spontaneous brain activity: effects of depression and antidepressant treatment

Magnetoencephalography (MEG) allows the real-time recording of neural activity and oscillatory activity in distributed neural networks. We applied a non-linear complexity analysis to resting-state neural activity as measured using whole-head MEG. Recordings were obtained from 20 unmedicated patients with major depressive disorder and 19 matched healthy controls. Subsequently, after 6 months of pharmacological treatment with the antidepressant mirtazapine 30 mg/day, patients received a second MEG scan. A measure of the complexity of neural signals, the Lempel–Ziv Complexity (LZC), was derived from the MEG time series. We found that depressed patients showed higher pre-treatment complexity values compared with controls, and that complexity values decreased after 6 months of effective pharmacological treatment, although this effect was statistically significant only in younger patients. The main treatment effect was to recover the tendency observed in controls of a positive correlation between age and complexity values. Importantly, the reduction of complexity with treatment correlated with the degree of clinical symptom remission. We suggest that LZC, a formal measure of neural activity complexity, is sensitive to the dynamic physiological changes observed in depression and may potentially offer an objective marker of depression and its remission after treatment.
Cytochrome c Release and Caspase Activation in Traumatic Axonal Injury

Axonal injury is a feature of traumatic brain injury (TBI) contributing to both morbidity and mortality. The traumatic axon injury (TAI) results from focal perturbations of the axolemma, allowing for calcium influx triggering local intraaxonal cytoskeletal and mitochondrial damage. This mitochondrial damage has been posited to cause local bioenergetic failure, leading to axonal failure and disconnection; however, this mitochondrial damage may also lead to the release of cytochrome c (cyto-c), which then activates caspases with significant adverse intraaxonal consequences. In the current communication, we examine this possibility. Rats were subjected to TBI, perfused with aldehydes at 15–360 min after injury, and processed for light microscopic (LM) and electron microscopic (EM) single-labeling immunohistochemistry to detect extramitochondrially localized cytochrome c (cyto-c) and the signature protein of caspase-3 activation (120 kDa breakdown product of α-spectrin) in TAI. Combinations of double-labeling fluorescent immunohistochemistry (D-FIHC) were also used to demonstrate colocalization of calpain activation with cyto-c release and caspase-3-induction. In foci of TAI qualitative–quantitative LM demonstrated a parallel, significant increase in cyto-c release and caspase-3 activation over time after injury. EM analysis demonstrated that cyto-c and caspase-3 immunoreactivity were associated with mitochondrial swelling–disruption in sites of TAI. Furthermore, D-IFHC revealed a colocalization of calpain activation, cyto-c release, and caspase-3 induction in these foci, which also revealed progressive TAI. The results demonstrate that cyto-c and caspase-3 participate in the terminal processes of TAI. This suggests that those factors that play a role in the apoptosis in the neuronal soma are also major contributors to the demise of the axonal appendage.