Miracle-dz/UniFAR-FTUs huggingface dataset:
University Versus Corporate Patents: A Window On The Basicness Of Invention

This paper is an attempt to quantify key aspects of innovations, 'basicness' and appropriability, and explore the linkages between them. We rely on detailed patent data. particularly on patent citations, thus awarding the proposed measures a very wide coverage. Relying on the prior that universities perform more basic research than corporations, we find that forward-looking measures of 'importance' and 'generality' capture aspects of the basicness of innovations. Similarly, measures of the degree of reliance on scientific sources. and of the closeness to the origins of innovational paths, appear to reflect the basicness of research. As measures of appropriability we use the fraction of citations coming from patents awarded to the sarne inventor, and in fact these measures are much higher for corporations than fbr universities. An examination of a small number of patents that are universally recognized as 'basic' provides further support for these measures. We find also evidence of the existence of 'technologl trajectories'.
Does Land Use Planning Shape Regional Economies? A Simultaneous Analysis of Housing Supply, Internal Migration and Local Employment Growth in the Netherlands

Why has job growth over the past decades been weaker in the Dutch Randstad area than in surrounding regions? In a simultaneous equations analysis, we find that employment has adjusted to the regional supply of labour. Net internal migration was predominantly determined by regional housing supply, and not by employment growth. Growth of the regional housing stock appeared insensitive to changes in the number of people and jobs. This lack of responsiveness to demand conditions is consistent with the presence of strong restrictions on residential development near the main Dutch cities, suggesting that the current regional distribution of economic activity in the Netherlands reflects land use planning decisions.
Cross-cultural training for Dutch expatriates going to India

The aim of this study is to gain insight into the challenges encountered by Dutch expatriates during their stay in India and into how Cross- Cultural Training (CCT) can be improved to help them handle these challenges adequately. For this explorative, in-depth study, CCT was split into five areas: adjustment to work; adjustment to interacting with host country nationals; adjustment to the general non-work environment; adjustment to Indian culture; and adjustment to the Indian context. Eighteen Dutch expatriates were interviewed. Data analysis included a discursive interpretation of the relevant quotes. A number of elements that can be improved in received CCT were identified in the five areas mentioned above.
The Creative Product and the Creative Processes in Virtual Environments

The effects of information technology on the creative performance in groups and individuals were examined. An experimental 3 2 design was used in order to assess the effects of computer-mediated and face-to-face interaction on creative performance. Forty-eight groups, divided into individuals or small three-person groups, worked on a heuristic task during three sessions. Creativity was operationalized in terms of the creative product and the creative process. The results regarding the creative product indicated that small groups had a higher flexibility than individuals. The small groups also proved to have significantly more incubations. Regarding the creative process, the face-to-face group showed a better flow, and this was especially valid in respect of the preparation phase. This study suggests that, providing there is a fully understood and well-prepared problem, attained or strengthened through face-to-face interaction; GCSS may serve as an important arena for exchanging and developing ideas.
On Bounds for Model Calibration Uncertainty

For a given derivative pricing model and an exotic product, one can ask the following natural question: if the model prices calibration instruments within their bid/ask spreads (or generally, given the model calibration error), what is the uncertainty of the exotic product valuation? This model calibration uncertainty can be defined through the coherent model risk measure of R.Cont. Here we give lower and upper bounds for this measure, which only depend on the stochastic dynamics specified by the model and its calibration, but not on a particular choice of the modelling parameters, and discuss a series of related questions.
Discounting and Underpricing of REIT Seasoned Equity Offers

For seasoned equity offerings, the discounting of the offer price from the closing price on the previous day is influenced by the level of asymmetric information surrounding the firm and the offering, as well as compensation to investors willing to purchase new shares. Discounting is important for the offering firm because it represents money left on the table, and this is the first paper to examine the degree of discounting and its determinants for real estate investment trusts (REITs). Studying the discounting of REIT seasoned equity offers from 1994 to 2006, this paper provides support for both the placement cost and value uncertainty hypotheses of discounting. When new REIT shares are more difficult to place with investors and there is less consensus about the valuation of REIT shares, investors will require greater discounting of the offer price.
The Cost of Algorithmic Trading

The authors examine transaction costs associated with algorithmic trading, based on a sample of 2.5 million orders, of which one million are executed via algorithmic means. The data permit a comparison of algorithmic executions with a broader universe of trades, as well as across multiple providers of model-based trading services. Algorithmic trading is found to be a cost-effective technique, based on a measure of implementation shortfall. The superiority of algorithm performance applies only for order sizes up to 10% of average daily volume, however. Algorithmic trading performance relative to a commonly used volume participation benchmark also is quite good, although certainty of outcome declines sharply with the size of the order. A clear link between performance and variability in performance relative to both benchmarks appears to be lacking. Although rough equality across providers is observed on average, this equality of performance breaks down quickly as order size grows.
Measuring regional effects of monetary policy in Canada

This article measures monetary policy shocks and examines whether the effects of such shocks have differential regional effects in Canada. We identify three possible sources of regional effects: differences in the importance of interest-sensitive industries, differences in the contribution of exports to output and differences in the proportion of small relative to large firms. Using the overnight interest rate as the instrument of monetary policy, we present impulse responses of industry output from a recursive vector autoregression, which incorporates a cointegrating relation. The results show that manufacturing and primary industries are the most interest sensitive. We conduct impulse responses of provincial employment from a monetary contraction. The results show that Newfoundland and Prince Edward Island (PEI), primary industry-based provinces, are strongly and adversely affected by a monetary contraction. Manitoba, Saskatchewan and Alberta, also primary-based, are also affected. Ontario, which is manufacturing-based, is also affected but to a lesser extent. The response of Quebec, New Brunswick, Nova Scotia and British Columbia are not statistically significant.
The Determinant of the Hospitality Industry's Unsystematic Risk: A Comparison Between Hotel and Restaurant Firms

ABSTRACT Unsystematic risk is accepted as an important factor in stock valuation. Despite the importance, little has been done to study the relationship of unsystematic risk to stock values in the hospitality industry. This study attempted to advance the understanding of financial variables that could be related to unsystematic risk of hospitality firms. Regression models were developed for hotel and restaurant firms, using unsystematic risk as the dependent variable and financial variables as independent variables. The major findings of this study indicate: 1) more profitable hospitality companies have less unsystematic risk, 2) reducing reliance on debt financing could reduce unsystematic risk, 3) the positive relationship between operating leverage and unsystematic risk, suggesting that decreasing operating leverage could mitigate the stock price volatility of hospitality firms, and 4) large hotel and restaurant firms have less unsystematic risk than small firms. This study should help management of hospitality firms incorporate effects of shareholder expectations into their operational decision making as an integral part of long-range financial planning.
Biodiversity assessment: state-of-the-art techniques in phylogenomics and species identification.

PREMISE OF THE STUDY Biodiversity assessment is the first step in protecting the complete range of morphological and genetic diversity of species on Earth, and in reaching the goals of conservation biology. Assessment begins with identifying organisms that make up biological communities and understanding evolutionary histories. Scientific advancements in molecular sequencing can help clarify and provide support for identifications. Massively parallel DNA sequencing technologies are being used to sequence complete genomes of model organisms; however, this resource has not been fully used for species identifications. Animal researchers commonly use one mitochondrial region, and groups of plant scientists have proposed numerous combinations of two or three chloroplast markers as genomic identifiers. Yet, nearly as many studies have reported that the proposed regions are uninformative in some plant groups and at various taxonomic levels. METHODS We propose a combination of whole (or nearly whole) chloroplast genomes, mitochondrial genes, and nuclear repeat regions for both species identifications and phylogenetic analyses, obtained from a simple total DNA extraction and one run on massively parallel DNA sequencing machines. KEY RESULTS We have recovered both coding and noncoding sequences from multiple genetic sources, providing genomic information for comparisons within and between multiple taxonomic levels. CONCLUSIONS In combination with morphological and other data, this abundance of genomic information will have a broad range of applications, including not only helping conservation biologists understand ecosystem biodiversity, but also understanding the evolutionary histories of organisms, mending damaged landscapes, and investigating interactions of plants with pollinators and pests.
Pubertal development and testicular function in the male growth hormone-deficient rat.

The pubertal development of a novel GH-deficient mutant, the dwarf rat, has been evaluated. The establishment of normal spermatogenic function within small testes suggests that GH plays no role in spermatogenic function during puberty and adult life. However, a reduction in testicular size may reflect a reduced Sertoli cell population, suggesting that GH may be of importance in prepubertal testicular development. Furthermore, marked differences between the homozygous dwarf rat and homozygous GH-deficient mouse mutants (e.g. Snell, Ames, pygmy and little mutants) have been demonstrated. It would appear that the GH deficiency in the rat mutant is far more specific for GH than those hitherto described in the mouse. In contrast to Snell dwarf mice mutants, pituitary and serum concentrations of FSH and LH are normal throughout pubertal development in the dwarf rat. Both spermatogenic function and seminal vesicle function develop normally, whilst in Snell dwarf mice spermatogenic function develops late in life and seminal vesicles remain infantile. Serum and testicular concentrations of androgen are also normal in dwarf rats. Homozygous dwarf rats have been shown to be fertile in previous studies; however, our observations suggest that despite spermatogenesis being qualitatively and quantitatively normal when assessed histologically, reduced testicular size seen in dwarf rats would lead to a reduced daily sperm output in these animals. The dwarf rat represents a mutant in which the consequences of the selective depletion of GH may be studied on various endocrine systems. The reproductive axis appears to be only partially affected, at an early age, by GH deficiency.
Berberis vulgaris extract/β-cyclodextrin complex increases protection of hepatic cells via suppression of apoptosis and lipogenesis pathways

Berberis vulgaris (Bv) is well known worldwide for its healing properties. However, limited information is available concerning its mechanism of action and the increased hepatoprotective activity of formulated extracts. This study evaluated the protective effect of Bv bark extract against CCl4-induced cytotoxicity in Huh7 cells, as well whether β-cyclodextrin complexation of the extract resulted in increased hepatoprotective effects. Huh7 cells were incubated for 48 h with 5, 7.5 and 10 µg/ml of unformulated or formulated Bv extract alone and in co-treatment with CCl4. The effects on Huh7 cell growth and apoptosis were evaluated by MTT assay, caspase-3/7 activity and caspase-3 expression, whereas fatty acid changes were investigated by Oil red O staining and the detection of peroxisome proliferator-activated receptor-γ (PPARγ) expression using immunofluorescence. Ultrastructural alterations were observed by electron microscopy. The MTT assay showed that co-exposure to CCl4 and 7.5 µg/ml formulated extract led to a 1.25-fold increase in cell viability compared with the non-formulated extract. Caspase-3/7 activity decreased by 50% and 70% following co-treatment with unformulated or formulated extract, compared with that in cells treated with CCl4 alone. Furthermore, hepatocyte ultrastructure was protected from CCl4-induced injury in the two co-treated groups, intracytoplasmic lipid accumulation decreased significantly and PPARγ expression was restored, in comparison with CCl4-treated cells alone. Formulated and unformulated extracts were efficient against the anti-proliferative and pro-apoptotic actions of CCl4 through suppression of CCl4-induced caspase-3 activation and lipid accumulation. The protective effect of the formulated extract was more pronounced than that of the unformulated one, which may be due to its increased solubility.
Diagnosis and treatment of osteoporosis following hip fracture in Chiang Mai University Hospital.

BACKGROUND Osteoporosis is defined as a skeletal disorder characterized by compromised bone strength predisposing a person to an increased risk of fracture. Hip fracture is the common and serious consequence of osteoporosis. To improve bone quality and prevent new fracture, osteoporosis should be treated while the patient was admitted with hip fracture problem. Several medications have been proven to be effective. Objectives of the present study were to determine the adequacy of diagnosis and treatment of osteoporosis in hip fracture patients. MATERIAL AND METHOD A retrospective study of all low energy trauma hip fracture patients, between 1998 and 2003 at the age of 50 years old or more. The National Osteoporosis Foundation guideline was used to identify adequacy of diagnosis and treatment of osteoporosis in this group of patients. Age, sex, admitted diagnosis, mechanism of injury, admission medication, treatment procedures, discharge medication, BMD investigation were analysed. RESULTS The percentage of calcium supplementation for the discharged patients in 1998 to 2003 was 0%, 10.5%, 33.3%, 32.7%, 39.3% and 43.0% respectively. The percentage of combination of calcium and vitamin D supplementation for the discharged patients was 0%, 8.8%, 21.1%, 12.7%, 24.6% and 37.5% respectively. Bisphosphonate was ordered in 9 and calcitonin in 20 patients. 7% of patients were diagnosied as osteoporosis. The quantity of osteoporosis was confirmed by DXA measurement in only one patient. CONCLUSIONS In the past 6 years, most of the hip fracture patients were underdiagnosed and undertreated for osteoporosis. There was also a good trend for better treatment.
A comparative study on the effect of Pandughnivati and Dhatrilauhavati in the management of Garbhinipandu (Iron Deficiency Anemia)

The desire to have a healthy progeny is innate and very intense in every livingbeing. The hectic life and tremendous stress in daily life has made the conception and continuation of pregnancy till term very difficult. Anemia is one of the common disease conditions, which affects a pregnant woman. In Ayurvedic classics anemia in pregnancy is taken under the Rasa Pradoshajavikara. It is clear that Garbhavasthajanyapandu occurs due to the fetal demands and improper functioning of the Rasadhatu leading to malnourishment of the body. A total of 26 patients were registered from out-patient department of Streeroga and Prasutitantra, out of which four patients discontinued. The remaining 22 patients were randomly divided into two groups; Group A (n-12) Pandughnivati two tablets of 500 mg tds and Group B (n-10) Dhatrilauhavati one tablet of 500 mg tds. Dhatrilauhavati was selected for the present study due to its Pandughna, Prinana, Raktaprasadana properties. In the present study, Pandughnivati a compound formulation developed by AYUSH department was administered for patients of group A. The results revealed that the over all clinical improvement was better in patients of Group B when compared to Group A. Hence it was concluded that Dhatrilauhavati was effective in treating anemia during pregnancy.
Spatially correlated exit strategies in the baking industry

This article uses a unique data set to analyse economic factors that explain firm exit and the interrelation across firms in space when exiting. Results show the effectiveness of modelling spatial correlation in a logit exit model. Indeed, in our application, reliable statistical results could only be drawn from our data when including spatial correlation in the model.
Job involvement and performance among middle managers in Sri Lanka

This paper examines performance evaluation outcomes for middle managers in the garment sector in Sri Lanka and seeks to explain variations in levels of job involvement and perceptions of organizational support. Some 155 middle managers across three firms were segregated into high- and low-performing groups. High-performing managers tended to have higher perceptions of organizational support, resulting in a social exchange relationship with their employer, and expressed higher job satisfaction and lower turnover intentions. Managers assessed as low performers experienced more negative perceptions of organizational support, lower job satisfaction and an economic exchange relationship with their employer. Significantly, for both high and low performers these outcomes were moderated by job involvement. These findings highlight the need for organizations to pay careful attention to the factors influencing job involvement and perceived organizational support. The paper concludes with a discussion on the practical implications of the findings for human resource managers.
Are skinfold measurements suitable to compare body fat between children with spastic cerebral palsy and healthy controls?

The aim of this study was to assess whether percentage of body fat (BF) can be predicted adequately from skinfold measurements in comparative studies of children with spastic cerebral palsy (CP) and healthy control children. The deuterium dilution technique (D2O) was used as a reference method. In contrast with what was expected, %BF predicted from skinfold measurements was considerably lower than that determined by the D2O method in children with CP, whereas in the controls this was not seen. A proportionally large internal fat deposit and a different distribution of subcutaneous fat in children with CP may be responsible for this. It was concluded that skinfold measurements are not suitable for predicting %BF in comparative studies of children with CP and control children. For evaluation of diet‐or exercise‐related interventions in children with CP, the use of skinfold measurements seems to be justified. However, it may be more appropriate to use skinfold thicknesses without converting them to BF.
Apathy in Parkinson’s disease

Objective: To assess apathy in patients with Parkinson’s disease and its relation to disability, mood, personality, and cognition. Methods: Levels of apathy in 45 patients with Parkinson’s disease were compared with a group of 17 similarly disabled patients with osteoarthritis. Additional neuropsychiatric data were collected concerning levels of depression, anxiety, and hedonic tone. Personality was assessed with the tridimensional personality questionnaire. Cognitive testing included the mini-mental state examination, the Cambridge examination of cognition in the elderly, and specific tests of executive functioning. Results: Patients with Parkinson’s disease had significantly higher levels of apathy than equally disabled osteoarthritic patients. Furthermore, within the Parkinson sample, levels of apathy appear to be unrelated to disease progression. The patients with Parkinson’s disease with the highest levels of apathy where not more likely to be depressed or anxious than those with the lowest levels of apathy, though they did show reduced hedonic tone. No differences in personality traits were detected in comparisons between patients with Parkinson’s disease and osteoarthritis, or between patients in the Parkinson group with high or low levels of apathy. As a group, the patients with Parkinson’s disease tended not to differ significantly from the osteoarthritic group in terms of cognitive skills. However, within the Parkinson’s disease sample, the high apathy patients performed significantly below the level of the low apathy patients. This was particularly evident on tests of executive functioning. Conclusions: Apathy in Parkinson’s disease is more likely to be a direct consequence of disease related physiological changes than a psychological reaction or adaptation to disability. Apathy in Parkinson’s disease can be distinguished from other psychiatric symptoms and personality features that are associated with the disease, and it is closely associated with cognitive impairment. These findings point to a possible role of cognitive mechanisms in the expression of apathy.
Efficient Isolation of Swine Influenza Viruses by Age-Targeted Specimen Collection

ABSTRACT The control of swine influenza virus (SIV) infection is paramount for increasing the productivity of pig farming and minimizing the threat of pandemic outbreaks. Thus, SIV surveillance should be conducted by region and on a regular basis. Here, we established a microneutralization assay specific for SIV seroprevalence surveillance by using reporter gene-expressing recombinant influenza viruses. Growth-based SIV seroprevalence revealed that most sows and piglets were positive for neutralizing antibodies against influenza viruses. In contrast, the 90-day-old growing pigs exhibited limited neutralizing activity in their sera, suggesting that this particular age of population is most susceptible to SIV infection and thus is an ideal age group for SIV isolation. From nasal swab specimens of healthy pigs in this age population, we were able to isolate SIVs at a higher incidence (5.3%) than those of previous reports. Nucleotide sequencing and phylogenetic analysis of the hemagglutinin (HA) genes revealed that the isolated SIVs have circulated and evolved in pigs but not have been recently introduced from humans, implying that a large number of SIV lineages may remain “undiscovered” in the global porcine populations. We propose that the 90-day-old growing pig-targeted nasal swab collection presented in this study facilitates global SIV surveillance and contributes to the detection and control of SIV infection.