Miracle-dz/UniFAR-FTUs huggingface dataset:
Influence of blood glucose level on the prognosis of patients with diabetes mellitus complicated with ischemic stroke

We carried out this meta-analysis for the aim of exploring the influence of diabetes mellitus (DM) on the prognosis of patients with ischemic stroke. Relevant studies were identified using computerized databases supplemented with manual search strategies. The included studies were strictly followed the inclusion and exclusion criteria. Case-control studies which related to the influence of DM on the prognosis of patients with ischemic stroke were selected. Statistical analyses were implemented with the STATA version 12.0 statistical software. Our current meta-analysis initially retrieved 253 studies (227 in Chinese and 26 in English), 13 studies (6 in English and 7 in Chinese) were eventually incorporated in this meta-analysis. These 13 case-control studies included 8463 patients altogether (3249 patients with DM complicated with ischemic stroke and 5214 patients with ischemic stroke). The results of this meta-analysis manifested that there was a significant difference of the blood glucose level at 48 h after stroke between patients with DM complicated with ischemic stroke and patients with ischemic stroke (standard mean difference [SMD] =1.27, 95% confidence interval [CI] =0.02–2.51, P = 0.047); however, the effectiveness, fatality, and the National Institutes of Health Stroke Scale (NIHSS) score in patients with DM complicated with ischemic stroke, and patients with ischemic stroke had no significant difference (effectiveness: risk ratio [RR] = 0.88, 95% CI = 0.75–1.03, P = 0.121; fatality: RR = 1.29, 95% CI = 0.97–1.71, P = 0.081; NIHSS score: SMD = −0.14, 95% CI = −1.56-1.28, P = 0.849). The current evidence suggests that there is statistical difference of the blood glucose level at 48 h after stroke between patients with DM complicated with ischemic stroke and patients with ischemic stroke, but there is no statistical difference of prognostic indicators between patients in two groups. Thus, our study provides certain clinical value.
A high resolution spatiotemporal model for in-vehicle black carbon exposure : quantifying the in-vehicle exposure reduction due to the Euro 5 particulate matter standard legislation

Several studies have shown that a significant amount of daily air pollution exposure is inhaled during trips. In this study, car drivers assessed their own black carbon exposure under real-life conditions (223 h of data from 2013). The spatiotemporal exposure of the car drivers is modeled using a data science approach, referred to as “microscopic land-use regression” (µLUR). In-vehicle exposure is highly dynamical and is strongly related to the local traffic dynamics. An extensive set of potential covariates was used to model the in-vehicle black carbon exposure in a temporal resolution of 10 s. Traffic was retrieved directly from traffic databases and indirectly by attributing the trips through a noise map as an alternative traffic source. Modeling by generalized additive models (GAM) shows non-linear effects for meteorology and diurnal traffic patterns. A fitted diurnal pattern explains indirectly the complex diurnal variability of the exposure due to the non-linear interaction between traffic density and distance to the preceding vehicles. Comparing the strength of direct traffic attribution and indirect noise map-based traffic attribution reveals the potential of noise maps as a proxy for traffic-related air pollution exposure. An external validation, based on a dataset gathered in 2010–2011, quantifies the exposure reduction inside the vehicles at 33% (mean) and 50% (median). The EU PM Euro 5 PM emission standard (in force since 2009) explains the largest part of the discrepancy between the measurement campaign in 2013 and the validation dataset. The µLUR methodology provides a high resolution, route-sensitive, seasonal and meteorology-sensitive personal exposure estimate for epidemiologists and policy makers.
Does Unlearning Impact Interaction of EHR End-Users?

: Organizations need to remain competitive in today’s marketplace. Technology change impacts knowledge competencies that require alteration quickly, to reduce operating costs, and eliminate human errors. Updating computer system documentation procedures require unlearning to maintain competency. Physician end-users possess specialized competencies, or knowledge base in documentation of patient data to the degree that these operations have become automatic. To change the knowledge base of practitioners, end-users must use intellectual capital to unlearn patient care EHR documentation. This study focused on competency change, with the perceptions and influencers of unlearning of old competencies during EHR updates.
Nice infinitary logics

Ordinary infinitary languages L_{lambda, kappa} satisfy the Interpolation Theorem only in the case lambda <= {aleph_1}, kappa = {aleph_0}, this include first order logic of course. There are also some pairs of such logics satifying interpolation, e.g. (L_{lambda^+,{aleph_0}}, L_{(2^lambda)^+, lambda^+}) . Does this come from an intermidiate logic satisfying it? Is it nice? unique? We define for kappa = beth_kappa a new logic L^1_kappa such that L_{kappa omega}< L^1_kappa LL_{kappa kappa} and L^1_kappa is very nice; in particular satisfies the Interpolation Theorem. Moreover, L^1_kappa has a model--theoretic characterization in the style of Lindstrom's Theorem in terms of a form of undefinability of well--order. We also define for strong limit kappa of cofinality aleph_0 a logic L^2_{kappa^+} such that L_{kappa^+, {aleph_0}}
Primary Rosai-Dorfman Disease of Bone Without Lymphadenopathy Diagnosed by Fine Needle Aspiration Cytology

BACKGROUND Solitary bone involvement without lymphadenopathy is a rare manifestation of Rosai-Dorfman disease, or sinus histiocytosis with massive lymphadenopathy (SHML). Only 11 cases have been reported in the literature to date, all diagnosed on histology. CASE A 7-year-old girl had a radiolucent, lytic lesion in the shaft of the tibia clinically simulating Ewing's sarcoma. Fine needle aspiration cytology (FNAC) showed a microscopic picture typical--of SHML. There was no lymphadenopathy. CONCLUSION Rosai-Dorfman disease sometimes involves bone without lymphadenopathy and can be diagnosed confidently on FNAC. To the best of our knowledge, this is the 12th case report of solitary bone involvement.
Isokinetic assessment of the hip muscles in patients with osteoarthritis of the knee

OBJECTIVES: To evaluate the difference in isokinetic strength of hip muscles between patients with knee osteoarthritis (OA) and matched healthy controls, and to establish the correlation between this isokinetic strength and pain and function in patients with knee OA. METHODS: 25 patients with a diagnosis of unilateral knee OA, 25 patients with bilateral knee OA, and 50 matched controls were evaluated using the visual analog scale for pain, knee Lequesne index, Western Ontario and McMaster Universities questionnaire and an isokinetic test. RESULTS: The groups were matched for age, gender and body mass index. The results of the isokinetic test revealed lower peak torque of the hip in patients with OA of the knee than in the control group for all movements studied. Strong correlations were found between the peak torque, visual analog scale and function. CONCLUSIONS: Patients with OA of the knee exhibit lower isokinetic strength in the hip muscles than healthy control subjects. Strengthening the muscles surrounding the hip joint may help to decrease pain in people with knee OA. Some correlations between pain/function and peak torque were found.
Thermal Balancing Policy for Streaming Computing on Multiprocessor Architectures

As feature sizes decrease, power dissipation and heat generation density exponentially increase. Thus, temperature gradients in multiprocessor systems on chip (MPSoCs) can seriously impact system performance and reliability. Thermal balancing policies based on task migration have been proposed to modulate power distribution between processing cores to achieve temperature flattening. However, in the context of MPSoC for multimedia streaming computing, where timeliness is critical, the impact of migration on quality of service must be carefully analyzed. In this paper we present the design and implementation of a lightweight thermal balancing policy that reduces on-chip temperature gradients via task migration. This policy exploits run-time temperature and load information to balance the chip temperature. Moreover, we assess the effectiveness of the proposed policy for streaming computing architectures using a cycle-accurate thermal-aware emulation infrastructure. Our results using a real-life software defined radio multitask benchmark show that our policy achieves thermal balancing while keeping migration costs bounded.
Oral Fluid vs. Urine Analysis to Monitor Synthetic Cannabinoids and Classic Drugs Recent Exposure.

BACKGROUND Urine is a common biological sample to monitor recent drug exposure, and oral fluid is an alternative matrix of increasing interest in clinical and forensic toxicology. Limited data are available about oral fluid vs. urine drug disposition, especially for synthetic cannabinoids. OBJECTIVE To compare urine and oral fluid as biological matrices to monitor recent drug exposure among HIV-infected homeless individuals. METHODS Seventy matched urine and oral fluid samples were collected from 13 participants. Cannabis, amphetamines, benzodiazepines, cocaine and opiates were analyzed in urine by the enzyme-multipliedimmunoassay- technique and in oral fluid by liquid chromatography tandem mass spectrometry (LCMSMS). Eleven synthetic cannabinoids were analyzed in urine and in oral fluid by LC-MSMS. RESULTS Five oral fluid samples were positive for AB-FUBINACA. In urine, 4 samples tested positive for synthetic cannabinoids PB-22, 5-Fluoro-PB-22, AB-FUBINACA, and metabolites UR-144 5-pentanoic acid and UR-144 4-hydroxypentyl. In only one case, oral fluid and urine results matched, both specimens being AB-FUBINACA positive. For cannabis, 40 samples tested positive in urine and 30 in oral fluid (85.7% match). For cocaine, 37 urine and 52 oral fluid samples were positive (75.7% match). Twenty-four urine samples were positive for opiates, and 25 in oral fluid (81.4% match). For benzodiazepines, 23 samples were positive in urine and 25 in oral fluid (85.7% match). CONCLUSION/DISCUSSION These results offer new information about drugs disposition between urine and oral fluid. Oral fluid is a good alternative matrix to urine for monitoring cannabis, cocaine, opiates and benzodiazepines recent use; however, synthetic cannabinoids showed mixed results.
Once-monthly risedronate for postmenopausal osteoporosis

Bisphosphonates are the mainstay of treatment for postmenopausal women with osteoporosis. Despite numerous clinical trials documenting efficacy, tolerability, and safety of bisphosphonate therapy, long-term persistence and adherence to these agents remains low. This has serious consequences for patients with osteoporosis in that medication non-compliance is associated with significantly higher fracture risk. This review explores the unique physicochemical properties of bisphosphonates that allow more convenient intermittent dosing and whether less frequent dosing regimens improve compliance. Bisphosphonates are now available as oral drugs (taken daily, weekly, or monthly) or as intravenous preparations (given every 3 months or annually). The safety and efficacy of these various preparations are reviewed and compared, with particular emphasis on the newest agent to be approved, once-monthly risedronate. In contrast to monthly oral ibandronate, risedronate is the first and only monthly oral bisphosphonate to offer both vertebral and non-vertebral fracture reduction, based upon non-inferiority trials. Whether the greater convenience of this monthly oral bisphosphonate will translate into improved compliance and lower fracture risk is yet to be determined.
Changes of the brain’s bioelectrical activity in cognition, consciousness, and some mental disorders

Background: An electroencephalogram (EEG) is an accepted method in neurophysiology with a wide application. Different types of brain rhythms indicate that simultaneous activity of the brain cortex neurons depend on the person’s mental state. Method: we have focus on reviewing the existing literature pertaining to changes of the brain’s bioelectrical activity that recorded from the scalp in different conditions such as cognition and some mental disorders. Result: The frequency of brain waves may indicate sleep, consciousness, cognition, and some mental disorders. Slow brain waves are seen in some conditions such as sleep, coma, brain death, depression, autism, brain tumors, obsessive–compulsive disorder (OCD), attention deficit hyperactivity disorder (ADHD), and encephalitis, while rapid waves are generally reported in conditions such as epilepsy, anxiety, posttraumatic stress disorder (PTSD), and drug abuse. Conclusion: Increase in the EEG rhythm is a marker of high brain activity that leads to high degrees of consciousness, while slow waves are suggestive of less brain activity. The pattern of EEG rhythm can be an indicator of some mental disorders, too.
CDKN2BAS polymorphisms are associated with coronary heart disease risk a Han Chinese population

The goal of our study was to determine whether CDKN2BAS polymorphisms are associated with coronary heart disease (CHD) risk in a Han Chinese population. Eight SNPs were genotyped in 676 men and 465 women. We used χ2 tests and genetic model analyses to evaluate associations between the SNPs and CHD risk. We found that rs10757274 was associated with an increased risk of CHD in both men (allele G: Odds ratio [OR] = 1.30, 95% confidence interval [CI]: 1.05-1.61, P = 0.018; codominant model: P = 0.042; recessive model: OR = 1.70, 95% CI: 1.10-2.62, P = 0.016; log-additive model: OR = 1.34, 95% CI: 1.05-1.71, P = 0.019) and women (dominant model: OR = 2.26, 95% CI: 1.28-3.99, P = 0.004). In addition, rs7865618 was associated with an 8.10-fold increased risk of CHD in women under a recessive model (OR = 8.10, 95% CI: 1.74-37.68, P = 0.006). Interestingly, the haplotype AA (rs10757274 and rs1333042) of CDKN2BAS was associated with decreased the risk of CHD in men (OR = 0.72, 95% CI: 0.55 - 0.95, P = 0.022).
Meta‐analysis of psychophysiological interactions: Revisiting cluster‐level thresholding and sample sizes

Within the neuroimaging community, coordinate based meta‐analyses (CBMAs) are essential for aggregating findings across studies and testing whether those studies report similar anatomical locations. This approach has been predominantly applied to studies that focus on whether activation of a brain region is associated with a given psychological process. In a recent paper, we used CBMA to examine a distinct set of studies—that is, those focusing on whether connectivity between brain regions is modulated by a given psychological process (Smith et al. [2016]: Hum Brain Mapp 37:2904–2917). Specifically, we reviewed 284 studies examining brain connectivity with psychophysiological interactions (PPI). Our meta‐analytic results indicated that PPI yields connectivity patterns that are consistent across studies and that can be specific for a given psychological process and seed region. After publication of our findings, we learned that the analysis software we used to conduct our CBMAs (GingerALE v2.3.3) contained an implementation error that led to results that were more liberal than intended. Here, we comment on the impact of this implementation error on the results of our paper, new recommendations for sample sizes in CBMAs, and the importance of communication between software users and developers. We show that our key claims are supported in a reanalysis and that our results are robust to new guidelines on sample sizes. Hum Brain Mapp 38:588–591, 2017. © 2016 Wiley Periodicals, Inc.
Fully Printed Flexible Single-Chip RFID Tag with Light Detection Capabilities

A printed passive radiofrequency identification (RFID) tag in the ultra-high frequency band for light and temperature monitoring is presented. The whole tag has been manufactured by printing techniques on a flexible substrate. Antenna and interconnects are realized with silver nanoparticles via inkjet printing. A sprayed photodetector performs the light monitoring, whereas temperature measurement comes from an in-built sensor in the silicon RFID chip. One of the advantages of this system is the digital read-out and transmission of the sensors information on the RFID tag that ensures reliability. Furthermore, the use of printing techniques allows large-scale manufacturing and the direct fabrication of the tag on the desired surface. This work proves for the first time the feasibility of the embedment of large-scale organic photodetectors onto inkjet printed RFID tags. Here, we solve the problem of integration of different manufacturing techniques to develop an optimal final sensor system.
Role of MLH1 methylation in esophageal cancer carcinogenesis and its clinical significance

The mutL homolog-1 (MLH1) is a DNA mismatch repair gene and has been reported to be frequently methylated in numerous cancers. However, the association between MLH1 methylation and esophageal cancer (EC), as well as its clinical significance, remains unclear. Hence, we conducted a systematic meta-analysis based on 19 articles (including 1384 ECs, 345 premalignant lesions, and 1244 healthy controls). Our analysis revealed that the frequency of MLH1 methylation was significantly elevated during EC carcinogenesis. In addition, we observed that MLH1 promoter methylation was associated with age (odds ratio [OR]=1.79; 95% CI =1.20–2.66), advanced tumor grade (OR=3.7; 95% CI =2.37–5.77), lymph node metastasis (OR=2.65; 95% CI =1.81–3.88), distant metastasis (OR=7.60; 95% CI =1.23–47.19), advanced clinical stage (OR=4.46; 95% CI =2.88–6.91), and poor prognosis in EC patients (hazard ratio =1.64, 95% CI =1.00–2.69). The pooled sensitivity, specificity, and area under the curve of MLH1 methylation in EC patients versus healthy individuals were 0.15, 0.99, and 0.77, respectively. Our findings indicate that MLH1 methylation is involved in the carcinogenesis, progression, and metastasis of EC. Moreover, methylated MLH1 could be a potential diagnostic and prognostic biomarker for EC.
Erratum Erratum : D ng , Y . ; et al . Photo ic Structure for Light Trapping in Thin Film Silicon S lar Cells : Desi n and Experiment . Coatings

One of the foremost challenges in designing thin-film silicon solar cells (TFSC) is devising efficient light-trapping schemes due to the short optical path length imposed by the thin absorber thickness. The strategy relies on a combination of a high-performance back reflector and an optimized texture surface, which are commonly used to reflect and scatter light effectively within the absorption layer, respectively. In this paper, highly promising light-trapping structures based on a photonic crystal (PC) for TFSCs were investigated via simulation and experiment. Firstly, a highly-reflective one-dimensional photonic crystal (1D-PC) was designed and fabricated. Then, two types of 1D-PC-based back reflectors (BRs) were proposed: Flat 1D-PC with random-textured aluminum-doped zinc oxide (AZO) or random-textured 1D-PC with AZO. These two newly-designed BRs demonstrated not only high reflectivity and sufficient conductivity, but also a strong light scattering property, which made them efficient candidates as the electrical contact and back reflector since the intrinsic losses due to the surface plasmon modes of the rough metal BRs can be avoided. Secondly, conical two-dimensional photonic crystal (2D-PC)-based BRs were investigated and optimized for amorphous a-SiGe:H solar cells. The maximal absorption value can be obtained with an aspect ratio of 1/2 and a period of 0.75 μm. To improve the full-spectral optical properties of solar cells, a periodically-modulated PC back reflector was proposed and experimentally demonstrated in the a-SiGe:H solar cell. This periodically-modulated PC back reflector, also called the quasi-crystal structure (QCS), consists of a large periodic conical PC and a randomly-textured Ag layer with a feature size of 500–1000 nm. The large periodic conical PC enables conformal growth of the layer, while the small feature size of Ag can further enhance the light scattering. In summary, a comprehensive study of the design, simulation and fabrication of 1D-PCand 2D-PC-based back reflectors for TFSCs was carried out. Total absorption and device performance enhancement were achieved with the novel PC light-trapping systems because of their high reflectivity or high scattering property. Further research is necessary to illuminate the optimal structure design of PC-based back reflectors and high solar cell efficiency.
The risks of using allogeneic cell lines for vaccine production: the example of Bovine Neonatal Pancytopenia

ABSTRACT Introduction: Bovine neonatal pancytopenia (BNP) is a hemorrhagic disease that emerged in calves across Europe in 2007. Its occurrence is attributed to immunization of the calf’s mother with a vaccine produced using an allogeneic cell line. Vaccine-induced alloantibodies specific for major-histocompatibility class I antigens are transferred from the mother to the calf via colostrum, leading to profound depletion of peripheral blood and bone marrow cells that is often fatal. Areas covered: Pubmed and Web of Science were used to search for literature relevant to BNP and the use of allogeneic vaccine cell lines. Following a review of the pathology and pathogenesis of this novel condition, we discuss potential risks associated with the use of allogeneic vaccine cell lines. Expert commentary: Although BNP is associated with a specific vaccine, it highlights safety concerns common to all vaccines produced using allogeneic cell lines. Measures to prevent similar vaccine-induced alloimmune-mediated adverse events in the future are discussed.
Green Synthesis, Characterization and Application of Proanthocyanidins-Functionalized Gold Nanoparticles

Green synthesis of gold nanoparticles using plant extracts is one of the more promising approaches for obtaining environmentally friendly nanomaterials for biological applications and environmental remediation. In this study, proanthocyanidins-functionalized gold nanoparticles were synthesized via a hydrothermal method. The obtained gold nanoparticles were characterized by ultraviolet and visible spectrophotometry (UV-Vis), Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM) and X-ray diffraction (XRD) measurements. UV-Vis and FTIR results indicated that the obtained products were mainly spherical in shape, and that the phenolic hydroxyl of proanthocyanidins had strong interactions with the gold surface. TEM and XRD determination revealed that the synthesized gold nanoparticles had a highly crystalline structure and good monodispersity. The application of proanthocyanidins-functionalized gold nanoparticles for the removal of dyes and heavy metal ions Ni2+, Cu2+, Cd2+ and Pb2+ in an aqueous solution was investigated. The primary results indicate that proanthocyanidins-functionalized gold nanoparticles had high removal rates for the heavy metal ions and dye, which implies that they have potential applications as a new kind of adsorbent for the removal of contaminants in aqueous solution.