Miracle-dz/UniFAR-FTUs huggingface dataset:
Worse Health‐Related Quality of Life at long‐term follow‐up in patients with Cushing's disease than patients with cortisol producing adenoma. Data from the ERCUSYN

Hypercortisolism in Cushing's syndrome (CS) is associated with impaired health‐related quality of life (HRQoL), which may persist despite remission. We used the data entered into the European Registry on Cushing's syndrome (ERCUSYN) to evaluate if patients with CS of pituitary origin (PIT‐CS) have worse HRQoL, both before and after treatment than patients with adrenal causes (ADR‐CS).
A New Silicone Structure for uSkin—A Soft, Distributed, Digital 3-Axis Skin Sensor and Its Integration on the Humanoid Robot iCub

Tactile sensing is one important element that can enable robots to interact with an unstructured world. By having tactile perception, a robot can explore its environment by touching objects. Like human skin, a tactile sensor that can provide rich information such as distributed normal and shear forces with high density can help the robot to recognize objects. In previous work, we introduced uSkin, a soft skin with distributed 3-axis force-sensitive elements and a center-to-center distance between the 3-axis load cells of 4.7 mm for the flat version. This letter presents a new structure for the distributed soft force transducer that reduces the crosstalk between the components of the 3-axis force measurements. Three dimensionally (3-D) printing the silicone structure eased the prototype production. However, the 3-D printed material has a higher hysteresis than the previously used Ecoflex. Microcontroller boards originally developed for the skin of iCub were implemented for uSkin, increasing the readout frequency and reducing the space requirements and number of wires. The sensor was installed on iCub and successfully used for shape exploration.
Prospective patient stratification into robust cancer‐cell intrinsic subtypes from colorectal cancer biopsies

Colorectal cancer (CRC) biopsies underpin accurate diagnosis, but are also relevant for patient stratification in molecularly‐guided clinical trials. The consensus molecular subtypes (CMSs) and colorectal cancer intrinsic subtypes (CRISs) transcriptional signatures have potential clinical utility for improving prognostic/predictive patient assignment. However, their ability to provide robust classification, particularly in pretreatment biopsies from multiple regions or at different time points, remains untested. In this study, we undertook a comprehensive assessment of the robustness of CRC transcriptional signatures, including CRIS and CMS, using a range of tumour sampling methodologies currently employed in clinical and translational research. These include analyses using (i) laser‐capture microdissected CRC tissue, (ii) eight publically available rectal cancer biopsy data sets (n = 543), (iii) serial biopsies (from AXEBeam trial, NCT00828672; n = 10), (iv) multi‐regional biopsies from colon tumours (n = 29 biopsies, n = 7 tumours), and (v) pretreatment biopsies from the phase II rectal cancer trial COPERNCIUS (NCT01263171; n = 44). Compared to previous results obtained using CRC resection material, we demonstrate that CMS classification in biopsy tissue is significantly less capable of reliably classifying patient subtype (43% unknown in biopsy versus 13% unknown in resections, p = 0.0001). In contrast, there was no significant difference in classification rate between biopsies and resections when using the CRIS classifier. Additionally, we demonstrated that CRIS provides significantly better spatially‐ and temporally‐ robust classification of molecular subtypes in CRC primary tumour tissue compared to CMS (p = 0.003 and p = 0.02, respectively). These findings have potential to inform ongoing biopsy‐based patient stratification in CRC, enabling robust and stable assignment of patients into clinically‐informative arms of prospective multi‐arm, multi‐stage clinical trials. © 2018 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.
Human‐Object Interactions Are More than the Sum of Their Parts

Abstract Understanding human‐object interactions is critical for extracting meaning from everyday visual scenes and requires integrating complex relationships between human pose and object identity into a new percept. To understand how the brain builds these representations, we conducted 2 fMRI experiments in which subjects viewed humans interacting with objects, noninteracting human‐object pairs, and isolated humans and objects. A number of visual regions process features of human‐object interactions, including object identity information in the lateral occipital complex (LOC) and parahippocampal place area (PPA), and human pose information in the extrastriate body area (EBA) and posterior superior temporal sulcus (pSTS). Representations of human‐object interactions in some regions, such as the posterior PPA (retinotopic maps PHC1 and PHC2) are well predicted by a simple linear combination of the response to object and pose information. Other regions, however, especially pSTS, exhibit representations for human‐object interaction categories that are not predicted by their individual components, indicating that they encode human‐object interactions as more than the sum of their parts. These results reveal the distributed networks underlying the emergent representation of human‐object interactions necessary for social perception.
EAACI Molecular Allergology User's Guide

The availability of allergen molecules (‘components’) from several protein families has advanced our understanding of immunoglobulin E (IgE)‐mediated responses and enabled ‘component‐resolved diagnosis’ (CRD). The European Academy of Allergy and Clinical Immunology (EAACI) Molecular Allergology User's Guide (MAUG) provides comprehensive information on important allergens and describes the diagnostic options using CRD. Part A of the EAACI MAUG introduces allergen molecules, families, composition of extracts, databases, and diagnostic IgE, skin, and basophil tests. Singleplex and multiplex IgE assays with components improve both sensitivity for low‐abundance allergens and analytical specificity; IgE to individual allergens can yield information on clinical risks and distinguish cross‐reactivity from true primary sensitization. Part B discusses the clinical and molecular aspects of IgE‐mediated allergies to foods (including nuts, seeds, legumes, fruits, vegetables, cereal grains, milk, egg, meat, fish, and shellfish), inhalants (pollen, mold spores, mites, and animal dander), and Hymenoptera venom. Diagnostic algorithms and short case histories provide useful information for the clinical workup of allergic individuals targeted for CRD. Part C covers protein families containing ubiquitous, highly cross‐reactive panallergens from plant (lipid transfer proteins, polcalcins, PR‐10, profilins) and animal sources (lipocalins, parvalbumins, serum albumins, tropomyosins) and explains their diagnostic and clinical utility. Part D lists 100 important allergen molecules. In conclusion, IgE‐mediated reactions and allergic diseases, including allergic rhinoconjunctivitis, asthma, food reactions, and insect sting reactions, are discussed from a novel molecular perspective. The EAACI MAUG documents the rapid progression of molecular allergology from basic research to its integration into clinical practice, a quantum leap in the management of allergic patients.
Extracting Semantic Relations for Scholarly Knowledge Base Construction

The problem of information extraction from scientific articles, found as PDF documents in large digital repositories, is gaining more attention as the amount of research findings continues to grow. We propose a system to extract semantic relations among entities in scholarly articles by making use of external syntactic patterns and an iterative learner. While information extraction from scholarly documents have been studied before, it has been focused mainly on the abstract and keywords. Our method extracts semantic entities as concepts and instances along with their attributes from the fully body text of documents. We extract two types of relationships between concepts in the text using an iterative learning algorithm. External data sources from the web such as the Microsoft concept graph, as well as query logs, are utilized to evaluate the quality of the extracted concepts and relations. The concepts are used to construct a scientific taxonomy covering the research content of the documents. To evaluate the system we apply our approach on a set of 10k scholarly documents and conduct several evaluations to show the effectiveness of the proposed methods. We show that our system obtains a 23% improvement in precision over existing web IE tools when they are applied to scholarly documents.
Twenty years of enamel matrix derivative: the past, the present and the future.

BACGROUND On June 5th, 2015 at Europerio 8, a group of leading experts were gathered to discuss what has now been 20 years of documented evidence supporting the clinical use of enamel matrix derivative (EMD). Original experiments led by Lars Hammarström demonstrated that enamel matrix proteins could serve as key regenerative proteins capable of promoting periodontal regeneration including new cementum, with functionally oriented inserting new periodontal ligament fibres, and new alveolar bone formation. This pioneering work and vision by Lars Hammarström has paved the way to an enormous amount of publications related to its biological basis and clinical use. Twenty years later, it is clear that all these studies have greatly contributed to our understanding of how biologics can act as mediators for periodontal regeneration and have provided additional clinical means to support tissue regeneration of the periodontium. AIMS This review article aims to: (1) provide the biological background necessary to understand the rational for the use of EMD for periodontal regeneration, (2) present animal and human histological evidence of periodontal regeneration following EMD application, (3) provide clinically relevant indications for the use of EMD and (4) discuss future avenues of research including key early findings leading to the development of Osteogain, a new carrier system for EMD specifically developed with better protein adsorption to bone grafting materials.
Lessons learned from a community-academic initiative: the development of a core competency-based training for community-academic initiative community health workers.

OBJECTIVES Despite the importance of community health workers (CHWs) in strategies to reduce health disparities and the call to enhance their roles in research, little information exists on how to prepare CHWs involved in community-academic initiatives (CAIs). Therefore, the New York University Prevention Research Center piloted a CAI-CHW training program. METHODS We applied a core competency framework to an existing CHW curriculum and bolstered the curriculum to include research-specific sessions. We employed diverse training methods, guided by adult learning principles and popular education philosophy. Evaluation instruments assessed changes related to confidence, intention to use learned skills, usefulness of sessions, and satisfaction with the training. RESULTS Results demonstrated that a core competency-based training can successfully affect CHWs' perceived confidence and intentions to apply learned content, and can provide a larger social justice context of their role and work. CONCLUSIONS This program demonstrates that a core competency-based framework coupled with CAI-research-specific skill sessions (1) provides skills that CAI-CHWs intend to use, (2) builds confidence, and (3) provides participants with a more contextualized view of client needs and CHW roles.
Arbitrage Pricing with Stochastic Volatility

We address the problem of pricing contingent claims in the presence of stochastic volatility. Former works claim that, as volatility itself is not a traded asset, no riskless hedge can be established, so equilibrium arguments have to be invoked and risk premia specified. We show that if instead of trying to find the prices of standard options we take these prices as exogenous, we can derive arbitrage prices of more complicated claims indexed on the Spot (and possibly on the volatility itself). This paper is an expansion of a former version presented at the AFFI conference in Paris, June 1992. I am grateful to Nicole El Karoui, Darrell Duffie, John Hull, and my colleagues from SORT (Swaps and Options Research Team) at Paribas for enriching conversations. All errors are indeed mine. Arbitrage Pricing with Stochastic Volatility 2
Trends in SiC MOSFET Threshold Voltage and ON-Resistance Measurements from Thermal Cycling and Electrical Switching Stresses Preprint

Integrating SiC power MOSFETs is very attractive for advancing power electronic systems, yet the system reliability with new devices remains in question. This work presents two accelerated test experiments to further investigate the packaging and semiconductor failures of a TO-247 SiC MOSFET. First, a variation on power cycling experiments— switching cycling—is introduced. Traditional power cycling experiments utilize conduction losses to self-heat the device where a large temperature swing causes degradation at the packaging level. However, by decreasing the on-time such that the device only turns on and immediately turns off, the temperature swing is decreased and the semiconductor itself is degraded. This work shows experimental device degradation caused by continuous switching events—switching cycling, at 90% of the device’s breakdown voltage. Second, thermal cycling experiments were conducted between -40°C and 175°C to observe degradation in the mechanical packaging of the device. Experimentally-measured changes in threshold voltage and ON-resistance are recorded in both experiments and compared. These results also illustrate the spectrum between device and package degradation from accelerated test methods.
Prevalence of Dural Ectasia in Loeys-Dietz Syndrome: Comparison with Marfan Syndrome and Normal Controls

Background and Purpose Dural ectasia is well recognized in Marfan syndrome (MFS) as one of the major diagnostic criteria, but the exact prevalence of dural ectasia is still unknown in Loeys−Dietz syndrome (LDS), which is a recently discovered connective tissue disease. In this study, we evaluated the prevalence of dural ectasia in LDS according by using qualitative and quantitative methods and compared our findings with those for with MFS and normal controls. Material and Methods We retrospectively studied 10 LDS (6 males, 4 females, mean age 36.3 years) and 20 MFS cases (12 males, 8 females, mean age 37.1 years) and 20 controls (12 males, 8 females, mean age 36.1 years) both qualitatively and quantitatively using axial CT images and sagittal multi-planar reconstruction images of the lumbosacral region. For quantitative examination, we adopted two methods: method-1 (anteroposterior dural diameter of S1> L4) and method-2 (ratio of anteroposterior dural diameter/vertebral body diameter>cutoff values). The prevalence of dural ectasia among groups was compared by using Fisher’s exact test and the Tukey−Kramer test. Results In LDS patients, the qualitative method showed 40% of dural ectasia, the quantitative method-1 50%, and the method-2 70%. In MFS patients, the corresponding prevalences were 50%, 75%, and 85%, and in controls, 0%, 0%, and 5%. Both LDS and MFS had a significantly wider dura than controls. Conclusions While the prevalence of dural ectasia varied depending on differences in qualitative and quantitative methods, LDS as well as MFS, showed, regardless of method, a higher prevalence of dural ectasia than controls. This finding should help the differentiation of LDS from controls.
The Ability of β-Cells to Compensate for Insulin Resistance is Restored with a Reduction in Excess Growth Hormone in Korean Acromegalic Patients

The aim of this study was to assess the prevalence of diabetes and to study the effects of excess growth hormone (GH) on insulin sensitivity and β-cell function in Korean acromegalic patients. One hundred and eighty-four acromegalic patients were analyzed to assess the prevalence of diabetes, and 52 naïve acromegalic patients were enrolled in order to analyze insulin sensitivity and insulin secretion. Patients underwent a 75 g oral glucose tolerance test with measurements of GH, glucose, insulin, and C-peptide levels. The insulin sensitivity index and β-cell function index were calculated and compared according to glucose status. Changes in the insulin sensitivity index and β-cell function index were evaluated one to two months after surgery. Of the 184 patients, 17.4% were in the normal glucose tolerance (NGT) group, 45.1% were in the pre-diabetic group and 37.5% were in the diabetic group. The insulin sensitivity index (ISI0,120) was significantly higher and the HOMA-IR was lower in the NGT compared to the diabetic group (P = 0.001 and P = 0.037, respectively). The ISI0,120 and disposition index were significantly improved after tumor resection. Our findings suggest that both insulin sensitivity and β-cell function are improved by tumor resection in acromegalic patients.
The “good death”: An integrative literature review

Abstract Objective: The “good death” is a dynamic concept and has evolved over time to become a “revivalist” good death: a planned, peaceful, and dignified death, at home, surrounded by family members. As the “good death” continues to evolve, the key questions are: How do cultural perceptions of death and dying change? What are the forces that shape Western attitudes and beliefs around death and dying? And how does the “good death” discourse frame the dying experience in contemporary society? The purpose of this manuscript is to describe the underlying discourse in the literature on the “good death” in Western societies. Method: An integrative literature review of data from experimental and nonexperimental sources in PubMed, CINAHL, PsychINFO, and SocINDEX of 39 articles from 1992 to 2014. Results: Four main themes emerged from reviewing 39 articles on the “good death”: (1) the “good death” as control, (2) the wrong “good death,” (3) the threatened “good death,” and (4) the denial of dying. Significance of Results: Evolving in response to prominent social attitudes and values, the contemporary “good death” is a powerful, constraining discourse that limits spontaneity and encourages one way to die. Social, political, and demographic changes now threaten the stability of the “good death”; dying is framed as an increasingly negative or even unnecessary process, thus marginalizing the positive aspects of dying and rendering dying absent, invisible.
Axioms for Modelling Cubical Type Theory in a Topos

The homotopical approach to intensional type theory views proofs of equality as paths. We explore what is required of an interval-like object I in a topos to give a model of type theory in which elements of identity types are functions with domain I. Cohen, Coquand, Huber and Mortberg give such a model using a particular category of presheaves. We investigate the extent to which their model construction can be expressed in the internal type theory of any topos and identify a collection of quite weak axioms for this purpose. This clarifies the definition and properties of the notion of uniform Kan filling that lies at the heart of their constructive interpretation of Voevodsky's univalence axiom. Furthermore, since our axioms can be satisfied in a number of different ways, we show that there is a range of topos-theoretic models of homotopy type theory in this style.
Discrete Subgroups Generated by Lattices in Opposite Horospherical Subgroups

0. Introduction. 1. Preliminaries. 1.1. Notation and terminology. 1.2. Some known algebraic lemmas. 1.3. Adjoint representation and maximal subgroups. 1.4. Qforms of algebraic groups and Q-rational representations. 1.5. Extension of Q-forms. 2. The subgroups of the form G and Q-forms. 2.1. Discrete subgroups in F , F 1 2 algebraic groups. 2.2. Generators of arithmetic groups. 2.3. Reflexive horospherical subgroups. 2.4. Margulis’ theorem on representation theŽ . ory and extension of Q-forms. 2.5. The subgroup generated by Z U1 Ž . and Z U . 2 3. Adjoint action on the space of lattices. 3.1. The space of lattices in algebraic unipotent groups. 3.2. Adjoint action. 3.3. Ratner’s theorem on orbit closures. 3.4. Closedness of some orbits and Q-forms. 4. The proof of the main theorem. 4.1. Commutative horospherical subgroup cases. 4.2. Heisenberg horospherical subgroup cases. 4.3. Non-RHeisenberg horospherical subgroup cases. 4.4. Arithmetic subgroups of the form G . F , F 1 2
Deep Sets

In this paper, we study the problem of designing objective functions for machine learning problems defined on finite \emph{sets}. In contrast to traditional objective functions defined for machine learning problems operating on finite dimensional vectors, the new objective functions we propose are operating on finite sets and are invariant to permutations. Such problems are widespread, ranging from estimation of population statistics \citep{poczos13aistats}, via anomaly detection in piezometer data of embankment dams \citep{Jung15Exploration}, to cosmology \citep{Ntampaka16Dynamical,Ravanbakhsh16ICML1}. Our main theorem characterizes the permutation invariant objective functions and provides a family of functions to which any permutation invariant objective function must belong. This family of functions has a special structure which enables us to design a deep network architecture that can operate on sets and which can be deployed on a variety of scenarios including both unsupervised and supervised learning tasks. We demonstrate the applicability of our method on population statistic estimation, point cloud classification, set expansion, and image tagging.
Experimental Heat Transfer Investigation of Tube Row Effects at AirSide Heat Exchanger with Serrated Finned-Tubes

Tube row effects on heat transfer at transverse serrated finned-tubes in cross-flow were investigated. The heat exchanger consists of finned-tubes, which are arranged as 8, 6, 4, 2 consecutive columns in flow direction, or as a single tube row, each consisting of 11 horizontal tubes. The tubes are arranged in a staggered formation at equal transverse and longitudinal pitch. The experimental setup, the measurement technique, and the measurement uncertainties are presented. After measurement validation, the derived correlations for the Nusselt number were compared with experimental results and equations from literature. A decreasing relative deviation with an increasing number of consecutive tube rows between counter-flow and counter cross-flow, in the formula for the calculation of the logarithmic mean temperature difference, can be seen. A reduction coefficient for finned-tube heat exchangers with few consecutive tube rows in gas flow was developed. Key-Words: Finned-tube, Serrated fin, Heat transfer, Pressure drop, Experimental setup, Helical finned-tube, Number of consecutive tube rows, Data validation