Miracle-dz/UniFAR-FTUs huggingface dataset:
On the Appropriateness of Complex-Valued Neural Networks for Speech Enhancement

Although complex-valued neural networks (CVNNs) â? networks which can operate with complex arithmetic â? have been around for a while, they have not been given reconsideration since the breakthrough of deep network architectures. This paper presents a critical assessment whether the novel tool set of deep neural networks (DNNs) should be extended to complex-valued arithmetic. Indeed, with DNNs making inroads in speech enhancement tasks, the use of complex-valued input data, specifically the short-time Fourier transform coefficients, is an obvious consideration. In particular when it comes to performing tasks that heavily rely on phase information, such as acoustic beamforming, complex-valued algorithms are omnipresent. In this contribution we recapitulate backpropagation in CVNNs, develop complex-valued network elements, such as the split-rectified non-linearity, and compare real- and complex-valued networks on a beamforming task. We find that CVNNs hardly provide a performance gain and conclude that the effort of developing the complex-valued counterparts of the building blocks of modern deep or recurrent neural networks can hardly be justified.
Teleoperation of Steerable Flexible Needles by Combining Kinesthetic and Vibratory Feedback

Needle insertion in soft-tissue is a minimally invasive surgical procedure that demands high accuracy. In this respect, robotic systems with autonomous control algorithms have been exploited as the main tool to achieve high accuracy and reliability. However, for reasons of safety and responsibility, autonomous robotic control is often not desirable. Therefore, it is necessary to focus also on techniques enabling clinicians to directly control the motion of the surgical tools. In this work, we address that challenge and present a novel teleoperated robotic system able to steer flexible needles. The proposed system tracks the position of the needle using an ultrasound imaging system and computes needle's ideal position and orientation to reach a given target. The master haptic interface then provides the clinician with mixed kinesthetic-vibratory navigation cues to guide the needle toward the computed ideal position and orientation. Twenty participants carried out an experiment of teleoperated needle insertion into a soft-tissue phantom, considering four different experimental conditions. Participants were provided with either mixed kinesthetic vibratory feedback or mixed kinesthetic-visual feedback. Moreover, we considered two different ways of computing ideal position and orientation of the needle: with or without set-points. Vibratory feedback was found more effective than visual feedback in conveying navigation cues, with a mean targeting error of 0.72 mm when using set-points, and of 1.10 mm without set-points.
Aromatase Knockout Mice Show Normal Steroid‐Induced Activation of Gonadotrophin‐Releasing Hormone Neurones and Luteinising Hormone Surges With a Reduced Population of Kisspeptin Neurones in the Rostral Hypothalamus

We recently reported that female aromatase knockout (ArKO) mice show deficits in sexual behaviour and a decreased population of kisspeptin‐immunoreactive neurones in the rostral periventricular area of the third ventricle (RP3V), resurrecting the question of whether oestradiol actively contributes to female‐typical sexual differentiation. To further address this question, we assessed the capacity of ArKO mice to generate a steroid‐induced luteinising hormone (LH) surge. Adult, gonadectomised wild‐type (WT) and ArKO mice were given silastic oestradiol implants s.c. and, 1 week later, received s.c. injections of either oestradiol benzoate (EB) followed by progesterone, EB alone, or no additional steroids to activate gonadotrophin‐releasing hormone (GnRH) neurones and generate an LH surge. Treatment with EB and progesterone induced significant Fos/GnRH double‐labelling and, consequently, an LH surge in female WT and in ArKO mice of both sexes but not in male WT mice. ArKO mice of both sexes had fewer cells expressing Kiss‐1 mRNA in the RP3V compared to female WT mice but had more Kiss‐1 mRNA‐expressing cells compared to WT males, reflecting an incomplete sexual differentiation of this system. To determine the number of cells expressing kisspeptin, the same experimental design was repeated in Experiment 2 with the addition of groups of WT and ArKO mice that were given EB + progesterone and sacrificed 2 h before the expected LH surge. No differences were observed in the number of kisspeptin‐immunoreactive cells 2 h before and at the time of the LH surge. The finding that ArKO mice of both sexes have a competent LH surge system suggests that oestradiol has predominantly defeminising actions on the GnRH/LH surge system in males and that the steroid‐induced LH surge can occur in females even with a greatly reduced population of kisspeptin neurones in the RP3V.
Epidemiology, Evolution, and Recent Outbreaks of Avian Influenza Virus in China

ABSTRACT Novel reassortants of H7N9, H10N8, and H5N6 avian influenza viruses (AIVs) are currently circulating in China's poultry flocks, occasionally infecting humans and other mammals. Combined with the sometimes enzootic H5N1 and H9N2 strains, this cauldron of genetically diverse AIVs pose significant risks to public health. Here, we review the epidemiology, evolution, and recent outbreaks of AIVs in China, discuss reasons behind the recent increase in the emergence of novel AIVs, and identify warning signs which may point to the emergence of a potentially virulent and highly transmissible AIV to humans. This review will be useful to authorities who consider options for the detection and control of AIV transmission in animals and humans, with the goal of preventing future epidemics and pandemics.
Pseudomonas aeruginosa ExoU, a Toxin Transported by the Type III Secretion System, Kills Saccharomyces cerevisiae

ABSTRACT ExoU, a protein transported by the type III secretion system of Pseudomonas aeruginosa, is an important cytotoxin, though its mechanism of action is unclear. Here we show that the intracellular expression of ExoU is cytotoxic to Saccharomyces cerevisiae. Furthermore, internal amino- and carboxyl-terminal deletions confirmed that regions of ExoU previously shown to be essential for killing mammalian cells were also required for killing yeast cells. These findings indicate that S. cerevisiae is a useful model organism for the study of ExoU.
The Wolf-Rayet population of the nearby barred spiral galaxy NGC 5068 uncovered by VLT and Gemini

We present a narrow-band VLT/FORS1 imaging survey of the SAB(rs)cd spiral galaxy NGC 5068, located at a distance of 5.45Mpc, from which 160 candidate Wolf-Rayet sources have been identified, of which 59 cases possess statistically significant 4686 excesses. Follow-up Gemini/GMOS spectroscopy of 64 candidates, representing 40% of the complete photometric catalogue, confirms Wolf-Rayet signatures in 30 instances, corresponding to a 47% success rate. 21 out of 22 statistically significant photometric sources are spectroscopically confirmed. Nebular emission detected in 30% of the Wolf-Rayet candidates spectrally observed, which enable a re-assessment of the metallicity gradient in NGC 5068. A central metallicity of log(O/H)+12 ~ 8.74 is obtained, declining to 8.23 at R_25. We combine our spectroscopy with archival Halpha images of NGC 5068 to estimate a current star formation rate of 0.63(+0.11/-0.13)Msun/yr, and provide a catalogue of the 28 brightest HII regions from our own continuum subtracted Halpha images, of which ~17 qualify as giant HII regions. Spectroscopically, we identify 24 WC and 18 WN-type Wolf-Rayet stars within 30 sources since emission line fluxes indicate multiple Wolf-Rayet stars in several cases. We estimate an additional ~66 Wolf-Rayet stars from the remaining photometric candidates, although sensitivity limits will lead to an incomplete census of visually faint WN stars, from which we estimate a global population of ~170 Wolf-Rayet stars. Based on the Halpha-derived O star population of NGC 5068 and N(WR)/N(O)~0.03, representative of the LMC, we would expect a larger Wolf-Rayet population of 270 stars. Finally, we have compared the spatial distribution of spectroscopically confirmed WN and WC stars with SDSS-derived supernovae, and find both WN and WC stars to be most consistent with the parent population of Type Ib SNe.
Evidence for Cardiomyocyte Repopulation by Extracardiac Progenitors in Transplanted Human Hearts

Human myocardium has long been considered to have essentially no intrinsic regenerative capacity. Recent studies in rodent models, however, have suggested the presence of an extracardiac stem cell population, perhaps in bone marrow, that is capable of some reconstitution of cardiomyocytes after injury. To determine whether similar mechanisms exist in the human heart, we evaluated human female allograft hearts transplanted into male patients. The presence of Y chromosomes in cardiomyocytes would indicate these cells arose from the recipient, rather than the donor heart. We identified 5 male patients who had retained a female heart at least 9 months before death and necropsy. Remarkably, in each case, the transplanted heart contained a minute but readily detectable fraction of Y chromosome-positive cardiomyocytes. The mean percentage of cardiomyocytes arising from the host was estimated to be 0.04% with a median of 0.016%. Most Y-positive cardiomyocytes were associated with regions of acute rejection, suggesting such chimerism involves an injury event. Furthermore, the sole patient whose immediate cause of death was allograft rejection showed a much higher percentage of host-derived cardiomyocytes, up to 29% in local, 1-mm2 “hot spots. ” Thus, adult humans have extracardiac progenitor cells capable of migrating to and repopulating damaged myocardium, but this process occurs at very low levels.
A Review of the Antimicrobial Activity of Chitosan

Chitosan, a versatile hydrophilic polysaccharide derived from chitin, has a broad antimicrobial spectrum to which gram-negative, gram-positive bacteria and fungi are highly susceptible. In the current review, three possible and accepted antimicrobial mechanisms for chitosan are presented and briefly discussed. The activity dependence on polymeric molecular weight (MW) and degree of acetylation (DA) are described. The chitosan minimum inhibitory concentrations (MIC) are summarized according to recent data found in the literature. The potential to improve inhibitory growth of bacteria by using water soluble chitosan derivatives is also discussed. The data indicate that the effectiveness of chitosan varies and is dependent on species of target microorganisms.
Diastolic Heart Failure in Dialysis Patients: Mechanisms, Diagnostic Approach, and Treatment

Heart failure (HF) is very common in the general population, and risk factors for HF, such as coronary artery disease, diabetes, obesity, and hypertension, are frequently present in patients with CKD. Therefore, HF is also an important cause of morbidity and mortality in this population. Diastolic heart failure (DHF), also called HF with preserved ejection fraction, refers to a clinical syndrome in which patients have symptoms and signs of HF, normal or near normal left ventricular (LV) systolic function, and evidence of diastolic dysfunction (e.g., abnormal LV filling and elevated filling pressure). Recent data suggest that HF with normal ejection fraction is even more common in patients than HF with low ejection fraction, including those on hemodialysis. Not surprisingly, DHF is a strong predictor of death in CKD patients. In this article, we review the information available on the mechanisms, clinical presentation, impact, and potential interventions in DHF based on evidence from CKD patients, as well as evidence from the general population potentially applicable to the CKD population.
The relationship between motor and mathematical problems in elementary school children

Few co-morbidity studies have been conducted since the Leeds Consensus Statement on developmental coordination disorder (DCD) in 2006. In this Statement, international cut-offs and inclusion criteria were agreed and consequently, the status of DCD changed. Furthermore, most existing co-morbidity studies are small clinical studies, rather than epidemiological studies, resulting in a broad range of co-morbidity rates. DCD has a higher incidence for boys in comparison with girls; questions arise if this preponderance remains the same in combination with other developmental disorders. Therefore, in this study we aimed to determine co-morbidity and gender differences of motor problems in children with a pervasive developmental disorder, a hyperkinetic disorder and/or a speech, language or learning disability. Profiles of 3,608 children (mean age: 9 years 1 month) referred to rehabilitation centres for behavioural, developmental and sensorineural disorders were studied. Motor problems were reported in one-fifth of the total sample. Co-morbidity of motor problems in specific disabilities varied from almost one-fourth to more than one-third. The male/female 1 Based on Pieters, S. , De Block, K. , Scheiris, J., Eyssen, M. , Desoete, A. , Deboutte, D. , . Roeyers, H. (2012). How common are motor problems in children with a developmental disorder: rule or exception? Child: Care, Health and Development, 38, 139-145. doi: 10.1111/j.1365-2214.2011. 01225.x 2 CHAPTER
An algorithm for multi-parametric quadratic programming and explicit MPC solutions

Explicit solutions to constrained linear model-predictive control (MPC) problems can be obtained by solving multi-parametric quadratic programs (mp-QP) where the parameters are the components of the state vector. We study the properties of the polyhedral partition of the state space induced by the multi-parametric piecewise linear solution and propose a new mp-QP solver. Compared to existing algorithms, our approach adopts a different exploration strategy for subdividing the parameter space, avoiding unnecessary partitioning and QP problem solving, with a significant improvement in efficiency.
Performance analysis of a dual round robin matching switch with exhaustive service

Virtual Output Queuing is widely used by fixed-length high-speed switches to overcome head-of-line blocking. This is done by means of matching algorithms. Maximum matching algorithms have good performance, but their implementation complexity is quite high. Maximal matching algorithms need speedup to guarantee good performance. Iterative algorithms (such as PIM and iSLIP) use multiple iterations to converge on a maximal match. The Dual Round-Robin Matching (DRRM) scheme has performance similar to iSLIP and lower implementation complexity. The objective of matching algorithms is to reduce the matching overhead for each time slot. The Exhaustive Service Dual Round-Robin Matching (EDRRM) algorithm amortizes the cost of a match over multiple time slots. While EDRRM suffers from a throughput below 100% for small switch sizes, it is conjectured to achieve an asymptotic 100% throughput under uniform traffic. Simulations show that it achieves high throughput under nonuniform traffic. Its delay performance is not sensitive to traffic burstiness, switch size and packet length. In an EDRRM switch cells belonging to the same packet are transferred to the output continuously, which leads to good packet delay performance and simplifies the implementation of packet reassembly. In this paper we analyze the performance of an EDRRM switch by using an exhaustive service random polling system model. This was used to predict the performance of switches too large to be simulated within a reasonable run time.
Northern Hemisphere Controls on Tropical Southeast African Climate During the Past 60,000 Years

The processes that control climate in the tropics are poorly understood. We applied compound-specific hydrogen isotopes (δD) and the TEX86 (tetraether index of 86 carbon atoms) temperature proxy to sediment cores from Lake Tanganyika to independently reconstruct precipitation and temperature variations during the past 60,000 years. Tanganyika temperatures follow Northern Hemisphere insolation and indicate that warming in tropical southeast Africa during the last glacial termination began to increase ∼3000 years before atmospheric carbon dioxide concentrations. δD data show that this region experienced abrupt changes in hydrology coeval with orbital and millennial-scale events recorded in Northern Hemisphere monsoonal climate records. This implies that precipitation in tropical southeast Africa is more strongly controlled by changes in Indian Ocean sea surface temperatures and the winter Indian monsoon than by migration of the Intertropical Convergence Zone.
Neuronal Death in Newborn Striatum after Hypoxia-Ischemia Is Necrosis and Evolves with Oxidative Stress

The mechanisms for neurodegeneration after hypoxia-ischemia (HI) in newborns are not understood. We tested the hypothesis that striatal neuron death is necrosis and evolves with oxidative stress and selective organelle damage. Piglets ( approximately 1 week old) were used in a model of hypoxia-asphyxia and survived for 3, 6, 12, or 24 h. Neuronal death was progressive over 3-24 h recovery, with approximately 80% of putaminal neurons dead at 24 h. Striatal DNA was digested randomly at 6-12 h. Ultrastructurally, dying neurons were necrotic. Damage to the Golgi apparatus and rough endoplasmic reticulum occurred at 3-12 h, while most mitochondria appeared intact until 12 h. Mitochondria showed early suppression of activity, then a transient burst of activity at 6 h, followed by mitochondrial failure (determined by cytochrome c oxidase assay). Cytochrome c was depleted at 6 h after HI and thereafter. Damage to lysosomes occurred within 3-6 h. By 3 h recovery, glutathione levels were reduced, and peroxynitrite-mediated oxidative damage to membrane proteins, determined by immunoblots for nitrotyrosine, occurred at 3-12 h. The Golgi apparatus and cytoskeleton were early targets for extensive tyrosine nitration. Striatal neurons also sustained hydroxyl radical damage to DNA and RNA within 6 h after HI. We conclude that early glutathione depletion and oxidative stress between 3 and 6 h reperfusion promote damage to membrane and cytoskeletal proteins, DNA and RNA, as well as damage to most organelles, thereby causing neuronal necrosis in the striatum of newborns after HI.
Adaptation of Arabidopsis to nitrogen limitation involves induction of anthocyanin synthesis which is controlled by the NLA gene

Plants can survive a limiting nitrogen (N) supply by developing a set of N limitation adaptive responses. However, the Arabidopsis nla (nitrogen limitation adaptation) mutant fails to produce such responses, and cannot adapt to N limitation. In this study, the nla mutant was utilized to understand further the effect of NLA on Arabidopsis adaptation to N limitation. Grown with limiting N, the nla mutant could not accumulate anthocyanins and instead produced an N limitation-induced early senescence phenotype. In contrast, when supplied with limiting N and limiting phosphorus (Pi), the nla mutants accumulated abundant anthocyanins and did not show the N limitation-induced early senescence phenotype. These results support the hypothesis that Arabidopsis has a specific pathway to control N limitation-induced anthocyanin synthesis, and the nla mutation disrupts this pathway. However, the nla mutation does not affect the Pi limitation-induced anthocyanin synthesis pathway. Therefore, Pi limitation induced the nla mutant to accumulate anthocyanins under N limitation and allowed this mutant to adapt to N limitation. Under N limitation, the nla mutant had a significantly down-regulated expression of many genes functioning in anthocyanin synthesis, and an enhanced expression of genes involved in lignin production. Correspondingly, the nla mutant grown with limiting N showed a significantly lower production of anthocyanins (particularly cyanidins) and an increase in lignin contents compared with wild-type plants. These data suggest that NLA controls Arabidopsis adaptability to N limitation by channelling the phenylpropanoid metabolic flux to the induced anthocyanin synthesis, which is important for Arabidopsis to adapt to N limitation.
3,5-Diiodo-L-Thyronine Activates Brown Adipose Tissue Thermogenesis in Hypothyroid Rats

3,5-diiodo-l-thyronine (T2), a thyroid hormone derivative, is capable of increasing energy expenditure, as well as preventing high fat diet-induced overweight and related metabolic dysfunction. Most studies to date on T2 have been carried out on liver and skeletal muscle. Considering the role of brown adipose tissue (BAT) in energy and metabolic homeostasis, we explored whether T2 could activate BAT thermogenesis. Using euthyroid, hypothyroid, and T2-treated hypothyroid rats (all maintained at thermoneutrality) in morphological and functional studies, we found that hypothyroidism suppresses the maximal oxidative capacity of BAT and thermogenesis, as revealed by reduced mitochondrial content and respiration, enlarged cells and lipid droplets, and increased number of unilocular cells within the tissue. In vivo administration of T2 to hypothyroid rats activated BAT thermogenesis and increased the sympathetic innervation and vascularization of tissue. Likewise, T2 increased BAT oxidative capacity in vitro when added to BAT homogenates from hypothyroid rats. In vivo administration of T2 to hypothyroid rats enhanced mitochondrial respiration. Moreover, UCP1 seems to be a molecular determinant underlying the effect of T2 on mitochondrial thermogenesis. In fact, inhibition of mitochondrial respiration by GDP and its reactivation by fatty acids were greater in mitochondria from T2-treated hypothyroid rats than untreated hypothyroid rats. In vivo administration of T2 led to an increase in PGC-1α protein levels in nuclei (transient) and mitochondria (longer lasting), suggesting a coordinate effect of T2 in these organelles that ultimately promotes net activation of mitochondrial biogenesis and BAT thermogenesis. The effect of T2 on PGC-1α is similar to that elicited by triiodothyronine. As a whole, the data reported here indicate T2 is a thyroid hormone derivative able to activate BAT thermogenesis.
Efficient pattern matching over event streams

Pattern matching over event streams is increasingly being employed in many areas including financial services, RFIDbased inventory management, click stream analysis, and electronic health systems. While regular expression matching is well studied, pattern matching over streams presents two new challenges: Languages for pattern matching over streams are significantly richer than languages for regular expression matching. Furthermore, efficient evaluation of these pattern queries over streams requires new algorithms and optimizations: the conventional wisdom for stream query processing (i.e., using selection-join-aggregation) is inadequate. In this paper, we present a formal evaluation model that offers precise semantics for this new class of queries and a query evaluation framework permitting optimizations in a principled way. We further analyze the runtime complexity of query evaluation using this model and develop a suite of techniques that improve runtime efficiency by exploiting sharing in storage and processing. Our experimental results provide insights into the various factors on runtime performance and demonstrate the significant performance gains of our sharing techniques.