Miracle-dz/UniFAR-FTUs huggingface dataset:
Beta-Amlyoid 1–42 and Tau-Protein in Cerebrospinal Fluid of Patients with Parkinson’s Disease Dementia

Measurement of τ-protein and β-amyloid1–42 (Aβ42) in cerebrospinal fluid (CSF) has gained increasing acceptance in the differential diagnosis of Alzheimer’s disease. We investigated CSF τ-protein and Aβ42 concentrations in 73 patients with advanced idiopathic Parkinson’s disease with dementia (PDD) and 23 patients with idiopathic Parkinson’s disease without dementia (PD) and in a comparison group of 41 non-demented neurological patients (CG) using commercially available enzyme-linked-immunoabsorbant-assay (ELISA). τ-Protein levels were statistically significantly higher and Aβ42 lower in the PDD patients compared to PD patients and the CG. This observation was most marked (p < 0.05) in a subgroup of patients with PDD carrying the apolipoprotein genotype Ε3/Ε3. The distribution of the apolipoprotein genotypes in PDD and PD patients was similar to that of the CG. Although a significant difference in τ-protein values was observed between PDD and CG, no diagnostic cut-off value was established. These findings suggest that such protein CSF changes may help to support the clinical diagnosis of cognitive decline in PD and that there may be apolipoprotein-E-isoform-specific differences in CSF protein regulation in advanced PDD.
Calidad de vida laboral en trabajadores de salud pública en Chile // Quality of work life in public health workers in Chile

Introduccion: La Calidad de Vida Laboral es una variable psicosocial que incorpora factores intrinsecos, ligados a la experiencia subjetiva en el trabajo y factores objetivos, propios del contenido del trabajo y del ambiente laboral. Objetivos: Evaluar si la calidad de vida laboral esta asociada a la satisfaccion laboral y al sindrome de burnout y analizar si existen diferencias significativas en la evaluacion de la calidad de vida laboral entre los estamentos organizacionales. Metodo: Bajo un diseno no experimental, analitico transversal, se recogieron datos de 72 trabajadores de un organismo de salud publica en Chile. Se utilizaron los cuestionarios de Satisfaccion laboral de Melia et al. (1990) de Calidad de Vida laboral de Da Silva (2006) y el inventario de Maslach para evaluar Burnout (Maslach y Jackson, 1986). Resultados: La calidad de vida laboral se asocio significativamente con la satisfaccion laboral y el sindrome de burnout. Ademas, se encontraron diferencias en funcion de la evaluacion de calidad de vida laboral entre el estamento directivo y tecnico (p ABSTRACT Introduction: The quality of work life is a relevant psychosocial variable, which has been studying in health organizations in recent years. This variable encompasses an intrinsic factor that links subjective experiences in work and an objective factor, which is associated with working content and working environment. Objectives: This study had two main aims. First, to determine whether quality of work life is correlated to job satisfaction and burnout syndrome; and second determine whether there is differences in terms of assessment of quality of work life in different organizational levels. Method: To achieve these goals, it collected 72 participants from a public health organization in Chile. Results: The quality of work life was significantly associated with job satisfaction and burnout syndrome. Additionally, it found that significant differences based on quality of work life’s assessment between manager and technical levels (p
ANALISIS FAKTOR-FAKTOR YANG BERPENGARUH TERHADAP PENDAPATAN PEREMPUAN PADA KELUARGA MISKIN DI KELURAHAN KAPAL KECAMATAN MENGWI KABUPATEN BADUNG

ABSTRAK Perekonomian sebuah keluarga dipengaruhi oleh pendapatan keluarga yang bersumber dari pendapatan suami. Pada keluarga miskin istri juga berkontribusi bagi pendapatan keluarga. Tujuannya: 1) kontribusi pendapatan istri terhadap pendapatan keluarga miskin, 2) ada atau tidaknya pengaruh simultan dan parsial faktor umur, tingkat pendidikan, jam kerja, sifat pekerjaan, jumlah tanggungan terhadap pendapatan perempuan pada keluarga miskin. Digunakan metode Proportionate Stratified Random Sampling, diambil sampel sebanyak 124 KK. Hasil penelitian menunjukkan bahwa rata-rata kontribusi pendapatan perempuan sebesar 49,07 persen. Umur, tingkat pendidikan, jam kerja, sifat pekerjaan dan jumlah tanggungan berpengaruh secara simultan dan parsial terhadap pendapatan perempuan pada keluarga miskin di Kelurahan Kapal. ABSTRACT Economy of a family affected by family income derived from their husbands. The wife also contribute to the family income. The goal: 1) the contribution of the wife income of poor family, 2) whether or not there is simultaneous and partial difference with respect to the factor of age, education, nature of job, working hours, and the number of dependents to the income of women in poor families in Kapal. Used Proportionate Stratified Random Sampling method that samples taken 124. The results showed that the average revenue contribution of women is 49.07 percent. Age, education, working hours and the number of dependents affected simultaneous and partial on income women in poor families in the Kapal Village.
Características que definen el fenómeno del botellón en universitarios y adolescentes

Se presentan algunos de los principales parametros del patron de conducta de los jovenes cuando realizan botellon, intentando superar la vision poco precisa que han generado los estudios de campo. Se han recogido 4083 encuestas de jovenes entre 14-25 anos de la ciudad de Valencia, durante el curso academico 2005/2006 a partir de una muestra aleatoria de centros educativos, acudiendo a las aulas y solicitando la colaboracion anonima y voluntaria. Los resultados confirman la reduccion progresiva en la edad de inicio en la practica del botellon, situandose en 13 anos para los adolescentes que en estos momentos tienen 14 anos. Asimismo niegan que se trate de una practica mayoritaria entre varones, al realizarla por igual ambos sexos. Tambien se confirma la tendencia europea que muestra una radicalizacion del consumo: incremento notorio de bebidas de alta graduacion independientemente de la edad y del sexo, llegando a tasas de alcoholemia medias de aproximadamente 1,5 gr. , con una frecuencia media de 2 veces por semana y durante mas de 6 meses al ano. Todo esto suele unirse a una falsa percepcion sobre los efectos derivados del consumo al sobredimensionar los aspectos positivos. Estos resultados plantean la necesidad de disenar una prevencion selectiva o incluso indicada -para aproximadamente el 20% de casos mas extremos-, superando la limitacion actual de prevencion universal. Tampoco puede obviarse la intervencion sobre la permisividad mostrada por los padres fundamentada en aspectos como la edad temprana de inicio en la practica del botellon o la hora de vuelta a casa tras su realizacion.
Assessment and resolution of difficult choices when deciding among alternatives

This chapter explores to what extent “choice deferral” and “coin tossing” are acceptable as means for resolving difficult choices, when trade off sizes are varied. Empirical evidence is presented, suggesting that choice deferral is accepted irrespective of the size of the trade off. Coin tossing, on the other hand, is predominantly accepted in the context of smaller trade off sizes. This observed difference in acceptability is explained by assuming that difficulty, as a function of trade off size, is accounted for by different underlying sources. Accordingly, it was found that, as an explanation for decision difficulty, (1) anticipated regret was more likely used for larger trade off sizes, (2) lacking compelling reasons for smaller trade off sizes, whereas (3) difficulty in trading off pros and cons was used as an explanation, irrespective the size of the trade off. Argued is that the observed correlation between the two means of resolving difficulty (deferral and coin tossing) and the different sources underlying difficulty, suggests that these two means can be employed as measurement tools for revealing possible sources underlying the experienced choice difficulty, when trade off size is varied.
Temporal logic with forgettable past

We investigate NLTL, a linear-time temporal logic with forgettable past. NLTL can be exponentially more succinct than LTL+Past (which in turn can be more succinct than LTL). We study satisfiability and model checking for NLTL and provide optimal automata-theoretic algorithms for these EXPSPACE-complete problems.
Mesopic Functional Visual Acuity in Normal Subjects

To evaluate mesopic functional visual acuity (FVA) with a newly developed system in normal subjects and to compare the results with photopic FVA, sixty-eight healthy volunteers (24.03 ± 4.42 [mean ± standard deviation] years) were enrolled in this study. A commercially available FVA measurement system (AS-28; Kowa, Aichi, Japan) was modified to measure FVA under mesopic conditions as well as photopic conditions. Measurements were performed monocularly in photopic conditions during 60 seconds. After dark adaptation for 15 minutes, the same measurements were repeated in mesopic conditions. Outcomes included starting visual acuity (VA), FVA (the average of VAs), visual maintenance ratio (VMR), maximum VA, minimum VA, and numbers of blinks during the 60-second measurement session, and were compared between mesopic and photopic conditions. Starting VA was –0.11 ± 0.08 and 0.39 ± 0.12 logarithm of the minimum angle of resolution (logMAR) in photopic and mesopic conditions, respectively. FVA was –0.06 ± 0.09 and 0.52 ± 0.14 logMAR, VMR was 0.98 ± 0.02 and 0.94 ± 0.04, maximum VA was –0.15 ± 0.06 and 0.33 ± 0.12 logMAR, the minimum VA was 0.05 ± 0.12 and 0.78 ± 0.20 logMAR, and the number of blinks was 8.23 ± 7.54 and 7.23 ± 6.20, respectively. All these parameters except the number of blinks were significantly different between the two conditions (P < 0.001). Besides, the difference between maximum and minimum VAs and standard deviation of VA were significantly larger in mesopic than in photopic conditions (P < 0.001). This study revealed that not only overall visual function decline but also instability of vision under mesopic conditions even in healthy subjects.
Improving pairwise learning for item recommendation from implicit feedback

Pairwise algorithms are popular for learning recommender systems from implicit feedback. For each user, or more generally context, they try to discriminate between a small set of selected items and the large set of remaining (irrelevant) items. Learning is typically based on stochastic gradient descent (SGD) with uniformly drawn pairs. In this work, we show that convergence of such SGD learning algorithms slows down considerably if the item popularity has a tailed distribution. We propose a non-uniform item sampler to overcome this problem. The proposed sampler is context-dependent and oversamples informative pairs to speed up convergence. An efficient implementation with constant amortized runtime costs is developed. Furthermore, it is shown how the proposed learning algorithm can be applied to a large class of recommender models. The properties of the new learning algorithm are studied empirically on two real-world recommender system problems. The experiments indicate that the proposed adaptive sampler improves the state-of-the art learning algorithm largely in convergence without negative effects on prediction quality or iteration runtime.
Strategizing from the middle in radical change situations

Purpose – Research has recognized the importance of middle management in the strategy process. Nonetheless, two questions raised by the involvement of middle management remain largely unexplored; they are central to this study. The first question concerns the conditions of this involvement. Before the 1970s, middle managers were subjected to operational processes. During the 1980s and 1990s they often embodied bureaucratic unwieldiness. How, then, has an actor in an organization migrated from a position excluded from the strategy process to a key position in this process? The second question concerns the functioning of the strategy process itself: what are the conditions of strategic creativity in this type of expanded process? This paper aims to address these issues.Design/methodology/approach – The approach taken is that of a longitudinal case study.Findings – On the basis of a seven‐year longitudinal case study of strategy practices in a firm facing radical change, this article pinpoints two research r.
Location Prediction of Social Images via Generative Model

The vast amount of geo-tagged social images has attracted great attention in research of predicting location using the plentiful content of images, such as visual content and textual description. Most of the existing researches use the text-based or vision-based method to predict location. There still exists a problem: how to effectively exploit the correlation between different types of content as well as their geographical distributions for location prediction. In this paper, we propose to predict image location by learning the latent relation between geographical location and multiple types of image content. In particularly, we propose a geographical topic model GTMSI (geographical topic model of social image) to integrate multiple types of image content as well as the geographical distributions. In GTMI, image topic is modeled on both text vocabulary and visual feature. Each region has its own distribution over topics and hence has its own language model and vision pattern. The location of a new image is estimated based on the joint probability of image content and similarity measure on topic distribution between images. Experiment results demonstrate the performance of location prediction based on GTMSI.
Overview of early response assessment in lymphoma with FDG-PET

Early assessment of response to chemotherapy with fluorine-18 fluorodeoxyglucose positron emission tomography (FDG-PET) is becoming a routine part of management in patients with Hodgkin lymphoma (HL) and histologically aggressive non-Hodgkin lymphoma (NHL). Changes in FDG uptake can occur soon after the initiation of therapy and they precede changes in tumour volume. Recent studies in uniform populations of aggressive lymphomas (predominantly diffuse large B cell lymphomas) and HL have clarified the value of early response assessment with PET. These trials show that PET imaging after 2–3 chemotherapy cycles is far superior to CT-based imaging in predicting progression-free survival and can be at least as reliable as definitive response assessment at the end of therapy. This information is of great potential value to patients, but oncologists should be cautious in the use of early PET response in determining choice of therapy until some critical questions are answered. These include: When is the best time to use PET for response assessment? What is the best methodology, visual or quantitative? (For HL at least, visual reading appears superior to an SUV-based assessment). Can early responders be cured with less intensive therapy? Will survival be better for patients treated more intensively because they have a poor interim metabolic response? In the future, early PET will be crucial in developing response-adapted therapy but without further carefully designed clinical trials, oncologists will remain uncertain how best to use this new information.
Correction of MFG-E8 Resolves Inflammation and Promotes Cutaneous Wound Healing in Diabetes

Milk fat globule epidermal growth factor-factor 8 (MFG-E8) is a peripheral glycoprotein that acts as a bridging molecule between the macrophage and apoptotic cells, thus executing a pivotal role in the scavenging of apoptotic cells from affected tissue. We have previously reported that apoptotic cell clearance activity or efferocytosis is compromised in diabetic wound macrophages. In this work, we test the hypothesis that MFG-E8 helps resolve inflammation, supports angiogenesis, and accelerates wound closure. MFG-E8−/− mice displayed impaired efferocytosis associated with exaggerated inflammatory response, poor angiogenesis, and wound closure. Wound macrophage-derived MFG-E8 was recognized as a critical driver of wound angiogenesis. Transplantation of MFG-E8−/− bone marrow to MFG-E8+/+ mice resulted in impaired wound closure and compromised wound vascularization. In contrast, MFG-E8−/− mice that received wild-type bone marrow showed improved wound closure and improved wound vascularization. Hyperglycemia and exposure to advanced glycated end products inactivated MFG-E8, recognizing a key mechanism that complicates diabetic wound healing. Diabetic db/db mice suffered from impaired efferocytosis accompanied with persistent inflammation and slow wound closure. Topical recombinant MFG-E8 induced resolution of wound inflammation, improvements in angiogenesis, and acceleration of closure, upholding the potential of MFG-E8–directed therapeutics in diabetic wound care.
Motivation in Education: Theory, Research, and Applications

Chapter 1. Motivation: Introduction and Historical Foundations Chapter 2. Expectancy-Value Theories of Motivation Chapter 3. Attribution Theory Chapter 4. Social Cognitive Theory Chapter 5. Goals and Goal Orientations Chapter 6. Interest and Affect Chapter 7. Intrinsic and Extrinsic Motivation Chapter 8. Sociocultural Influences Chapter 9. Teacher Influences Chapter 10. Classroom and School Influences Glossary References Name Index Subject Index
Topological and limit-space subcategories of countably-based equilogical spaces

There are two main approaches to obtaining ‘topological’ cartesian-closed categories. Under one approach, one restricts to a full subcategory of topological spaces that happens to be cartesian closed – for example, the category of sequential spaces. Under the other, one generalises the notion of space – for example, to Scott's notion of equilogical space. In this paper, we show that the two approaches are equivalent for a large class of objects. We first observe that the category of countably based equilogical spaces has, in a precisely defined sense, a largest full subcategory that can be simultaneously viewed as a full subcategory of topological spaces. In fact, this category turns out to be equivalent to the category of all quotient spaces of countably based topological spaces. We show that the category is bicartesian closed with its structure inherited, on the one hand, from the category of sequential spaces, and, on the other, from the category of equilogical spaces. We also show that the category of countably based equilogical spaces has a larger full subcategory that can be simultaneously viewed as a full subcategory of limit spaces. This full subcategory is locally cartesian closed and the embeddings into limit spaces and countably based equilogical spaces preserve this structure. We observe that it seems essential to go beyond the realm of topological spaces to achieve this result.
Combining Musical and Cultural Features for Intelligent Style Detection

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Urinary NGAL is a useful clinical biomarker of HIV-associated nephropathy.

BACKGROUND Urinary neutrophil gelatinase-associated lipocalin (uNGAL) is expressed by kidney tubules that are acutely damaged, but few studies have investigated the association of neutrophil gelatinase-associated lipocalin (NGAL) with different forms of chronic kidney disease (CKD). HIV-associated nephropathy (HIVAN) is a progressive form of CKD characterized by collapsing focal segmental glomerulosclerosis and microcytic tubular dilatation that typically leads to end-stage renal disease (ESRD). METHODS Previously, we reported that microcystic tubular dilatations specifically expressed NGAL RNA, implying that the detection of uNGAL protein could mark advanced HIVAN. To test this idea, we performed a comparative study of diverse proteinuric glomerulopathies in 25 patients who were HIV positive. RESULTS Eighteen patients had HIVAN and seven had other glomerulopathies (four membranoproliferative glomerulonephritis, one membranous glomerulonephritis, one amyloid and one malarial GN). HIVAN and non-HIVAN patients did not differ with respect to age, ethnicity, serum creatinine, estimated GFR, proteinuria or the prevalence of hypocomplementemia (6 versus 29%, P = 0.18), but HIVAN patients were less likely to have HCV infections. HIVAN patients expressed 4-fold higher levels of uNGAL than the patients with other glomerulopathies [387 ± 338 versus 94 ± 101 μg/g urine creatinine (uCr), P = 0.02]. A cutpoint of 121.5 μg uNGAL/g uCr demonstrated 94% sensitivity and 71% specificity for the diagnosis of HIVAN, with an area under the receiver operator characteristic curve of 0.88. CONCLUSION In summary, while HIVAN disease is currently diagnosed only by kidney biopsy, uNGAL can distinguish HIVAN from other proteinuric glomerulopathies in the HIV-infected patient, likely because of its specific expression from characteristic microcysts.
Sectarianism in Scotland: A ‘West of Scotland’ Problem, a Patchwork or a Cobweb?

Drawing on research carried out for the Scottish Government in 2014, this article explores how people experience sectarianism in Scotland today. For some, sectarianism is manifestly part of their everyday experience, but for others it is almost invisible in their social world. The article sets out a metaphor of sectarianism experienced like a cobweb in Scotland; running strongly down the generations and across masculine culture particularly, but experienced quite differently by different people depending on their social relationships. Using the examples of song and marching, the article suggests that sectarian prejudice should be conceived of as much as a cultural phenomenon as in social and legal terms. A multidisciplinary and intergenerational approach to tackling sectarian prejudice would help emphasise its cultural and relational construction. Much can also be learned from examining the broader research on prejudice worldwide, rather than treating Scottish sectarianism as if it is a unique and inexpli.
Performance of Alamouti Space-Time Coded OFDM with Carrier Frequency Offset

We investigate the error probability for Alamouti space-time coded orthogonal frequency-division multiplexing (OFDM) systems with carrier frequency offset (CFO) and multipath fading channels. Our main assumptions are: frequency-selective Rayleigh fading, a single receive antenna, and coherent detection. We derive new closed-form results for the (symbol or bit) error probability, for both spatially uncorrelated channels and spatially correlated channels. The proposed analysis shows that the error floor due to the CFO is strongly dependent on the power-delay profile of the multipath channel. Simulation results confirm the accuracy of the proposed theoretical analysis.
Methods for Using Selection on Observed Variables to Address Selection on Unobserved Variables

In this paper we develop new estimation methods for identifying causal effects based on the idea that the amount of selection on the observed explanatory variables in a model provides a guide to the amount of selection on the unobservables. Our approach involves the use of factor model as a way to infer properties of unobserved covariates from the observed covariates. We propose a confidence interval estimator that covers the true value of the causal effect.