Miracle-dz/UniFAR-FTUs huggingface dataset:
Estrogen Receptor Alpha Polymorphisms, Estradiol Level, and Occurrence of Atherosclerosis Risk Factors in Healthy Postmenopausal Women

Background The objective of the study was to analyze the relationship between interaction of polymorphisms in the estrogen receptor alpha gene (Erα) and estradiol (E2), and the occurrence of selected atherosclerosis risk factors in postmenopausal women without the diagnosis of a cardiovascular disease. Material/Methods The study covered 210 women, a minimum of 2 years after menopause, with FSH >30 mlU/ml, aged 50–60 years, with no chronic diseases diagnosed. In the women examined, the levels of estradiol, total cholesterol, HDL-cholesterol, LDL-cholesterol, and triglycerides were determined, as well as height, waist circumference (W), hip circumference (R), and arterial hypertension. The BMI and W/H ratio were calculated. Genotyping of the ER-α polymorphism was performed using a polymerase chain reaction and restriction enzymes (PCR-RFLP). The alleles of the XbaI polymorphism were defined as A and G: heterozygote AG, wild type GG and homozygote AA. The alleles of PvuII polymorphism were defined as T and C: heterozygote TC, homozygote TT, and wild type CC. Results The concentration of endogenous estradiol and ERα XbaI and PuvII polymorphisms as independent parameters did not significantly affect the BMI, waist circumference, W/H ratio, levels of CHOL, HDL, LDL, TG, or LDL/HDL, nor the systole and diastole in the postmenopausal women in the study. Conclusions The presented study suggests that ERα XbaI AA polymorphism may intensify the beneficial effect of estradiol on the distribution of fatty tissue after menopause; ERα XbaI GG and PuvII TC genotypes may intensify the beneficial effect of estradiol on HDL level; ERα PuvII TT genotype unfavorably modifies the relation between concentration of estradiol and systolic pressure after menopause.
Neutrino masses from operator mixing

We show that in theories that reduce, at the Fermi scale, to an extension of the standard model with two doublets, there can be additional dimension five operators giving rise to neutrino masses. In particular there exists a singlet operator which can not generate neutrino masses at tree level but generates them through operator mixing. Under the assumption that only this operator appears at tree level we calculate the neutrino mass matrix. It has the Zee mass matrix structure and leads naturally to bimaximal mixing. However, the maximal mixing prediction for solar neutrinos is very sharp even when higher order corrections are considered. To allow for deviations from maximal mixing a fine tuning is needed in the neutrino mass matrix parameters. However, this fine tuning relates the departure from maximal mixing in solar neutrino oscillations with the neutrinoless double beta decay rate.
A Simple Proof for Recoverability of `1-Minimization

It is well-known by now that `1 minimization can help recover sparse solutions to under-determined linear equations or sparsely corrupted solutions to over-determined equations, and the two problems are equivalent under appropriate conditions. So far almost all theoretic results have been obtained through studying the “under-determined side” of the problem. In this note, we take a different approach from the “overdetermined side” and show that a recoverability result (with the best available order) follows almost immediately from an inequality of Garnaev and Gluskin. We also connect dots with recoverability conditions obtained from different spaces.
Expectancy effects of pain and disgust in perceptual and moral decisions

Although expectancy effects have been described before (e.g. placebo effect), no one ever questioned their specificity. After all, it might be that when people anticipate pain, they form a representation of the approaching event, which could be shared with other aversive experiences, such as the case of disgust. In the present thesis, I examined the nature and specificity of expectancy of pain and disgust in the context of perceptual decisions (Experiments 1 & 2) and higher cognitive (moral) decisions (Experiments 3 & 4). I conducted four experiments to analyze behavioral, physiological and neural measures (using fMRI) from healthy human volunteers, which were all engaged in a new experimental set-up, specifically developed for testing the following experimental questions: (1) to which degree pain and disgust expectations recruit similar/dissociated representations of the upcoming event? (2) to which extent pain and disgust expectations affect high-level decisions, such as those involving morally-questionable behavior?
Evolving mass spectra of the oxidized component of organic aerosol: results from aerosol mass spectrometer analyses of aged diesel emissions

The species and chemistry responsible for secondary organic aerosol (SOA) formation remain highly uncertain. Laboratory studies of the oxidation of individual, high-flux SOA precursors do not lead to particles with mass spectra (MS) matching those of ambient aged organic material. Additionally, the complexity of real organic particles challenges efforts to identify their chemical origins. We have previously hypothesized that SOA can form from the atmospheric oxidation of a large suite of precursors with varying vapor pressures. Here, we support this hypothesis by using an aerosol mass spectrometer to track the chemical evolution of diesel exhaust as it is photochemically oxidized in an environmental chamber. With explicit knowledge of the condensed-phase MS of the primary emissions from our engine, we are able to decompose each recorded MS into contributing primary and secondary spectra throughout the experiment. We find that the SOA becomes increasingly oxidized as a function of time, quickly approaching a final MS that closely resembles that of ambient aged organic particulate matter. This observation is consistent with our hypothesis of an evolving suite of SOA precursors. Low vapor pressure, semi-volatile organic emissions can form condensable products with even a single generation of oxidation, resulting in an early-arising, relatively less-oxidized SOA. Continued gas-phase oxidation can form highly oxidized SOA in surprisingly young air masses via reaction mechanisms that can add multiple oxygen atoms per generation and result in products with sustained or increased reactivity toward OH.
Detecting Cancer Metastases on Gigapixel Pathology Images

Each year, the treatment decisions for more than 230,000 breast cancer patients in the U.S. hinge on whether the cancer has metastasized away from the breast. Metastasis detection is currently performed by pathologists reviewing large expanses of biological tissues. This process is labor intensive and error-prone. We present a framework to automatically detect and localize tumors as small as 100 x 100 pixels in gigapixel microscopy images sized 100,000 x 100,000 pixels. Our method leverages a convolutional neural network (CNN) architecture and obtains state-of-the-art results on the Camelyon16 dataset in the challenging lesion-level tumor detection task. At 8 false positives per image, we detect 92.4% of the tumors, relative to 82.7% by the previous best automated approach. For comparison, a human pathologist attempting exhaustive search achieved 73.2% sensitivity. We achieve image-level AUC scores above 97% on both the Camelyon16 test set and an independent set of 110 slides. In addition, we discover that two slides in the Camelyon16 training set were erroneously labeled normal. Our approach could considerably reduce false negative rates in metastasis detection.
Social workers’ perspectives on the recovery-oriented mental health practice in Tshwane, South Africa

ABSTRACT The challenge facing the mental health field today is the lack of knowledge related to interventions and services that will help people recover from severe mental health problems. In addition, the reluctance of social workers to embrace the recovery-oriented mental health practice is attributed to their lack of knowledge. Hence, they regard recovery in mental health as misleading and unrealistic.The article provides the findings on the social workers’ lack of knowledge and understanding of the recovery-oriented mental health practice. The social workers are based in non-governmental organizations in Tshwane, South Africa. Semi-structured interviews were conducted to gather data from social workers. Findings confirmed the lack of knowledge regarding the recovery-oriented approach, which has not yet been implemented in South Africa. Mental health services continue to be informed by the traditional medical model.
Auditory Short-Term Memory Behaves Like Visual Short-Term Memory

Are the information processing steps that support short-term sensory memory common to all the senses? Systematic, psychophysical comparison requires identical experimental paradigms and comparable stimuli, which can be challenging to obtain across modalities. Participants performed a recognition memory task with auditory and visual stimuli that were comparable in complexity and in their neural representations at early stages of cortical processing. The visual stimuli were static and moving Gaussian-windowed, oriented, sinusoidal gratings (Gabor patches); the auditory stimuli were broadband sounds whose frequency content varied sinusoidally over time (moving ripples). Parallel effects on recognition memory were seen for number of items to be remembered, retention interval, and serial position. Further, regardless of modality, predicting an item's recognizability requires taking account of (1) the probe's similarity to the remembered list items (summed similarity), and (2) the similarity between the items in memory (inter-item homogeneity). A model incorporating both these factors gives a good fit to recognition memory data for auditory as well as visual stimuli. In addition, we present the first demonstration of the orthogonality of summed similarity and inter-item homogeneity effects. These data imply that auditory and visual representations undergo very similar transformations while they are encoded and retrieved from memory.
Simple and fast optimistic protocols for fair electronic exchange

Assume each of two parties has something the other wants. Then, a fair exchange is an electronic protocol guaranteeing that either both parties get what they want, or none of them does. Protocols relying on traditional trusted parties easily guarantee such exchanges, but are inefficient (because a trusted party must be part of every execution) and expensive (because trusted parties want to be paid for each execution). In this paper we• Quickly review fair exchanges that are optimistic, that is, relying on a trusted party that (1) does not participate at all in an honest execution, and yet (2) guarantees the fairness of all executions; and• Present some older and surprisingly simple optimistic protocols for fair certified e-mail and contract signing that never appeared in the scientific literature.
The evidence from systematic reviews and meta-analyses published in orthodontic literature. Where do we stand?

AIM To analyse meta-analyses included in systematic reviews (SRs) published in leading orthodontic journals and the Cochrane Database of Systematic Reviews (CDSR) focusing on orthodontic literature and to assess the quality of the existing evidence. MATERIALS AND METHODS Electronic searching was undertaken to identify SRs published in five major orthodontic journals and the CDSR between January 2000 and June 2014. Quality assessment of the overall body of evidence from meta-analyses was conducted using the Grading of Recommendations Assessment, Development and Evaluation working group (GRADE) tool. RESULTS One hundred and fifty-seven SRs were identified; meta-analysis was present in 43 of these (27.4 per cent). The highest proportion of SRs that included a meta-analysis was found in Orthodontics and Craniofacial Research (6/13; 46.1 per cent), followed by the CDSR (12/33; 36.4 per cent) and the American Journal of Orthodontics and Dentofacial Orthopaedics (15/44; 34.1 per cent). Class II treatment was the most commonly addressed topic within SRs in orthodontics (n = 18/157; 11.5 per cent). The number of trials combined to produce a summary estimate was small for most meta-analyses with a median of 4 (range: 2-52). Only 21 per cent (n = 9) of included meta-analyses were considered to have a high/moderate quality of evidence according to GRADE, while the majority were of low or very low quality (n = 34; 79.0 per cent). CONCLUSIONS Overall, approximately one quarter of orthodontic SRs included quantitative synthesis, with a median of four trials per meta-analysis. The overall quality of evidence from the selected orthodontic SRs was predominantly low to very low indicating the relative lack of high quality of evidence from SRs to inform clinical practice guidelines.
Ethnicity and adolescent well-being in the context of families, friends, and neighborhoods

ABSTRACT Adolescent mental well-being may be affected in various ways by the experience of migration. Socioeconomic resources and social support affect adolescent well-being, but little is known about the importance of such resources among ethnic groups in immediate versus more distant environments. The aim of this study is to explore ethnic differences in well-being by family affluence, social support and ethnic diversity at both individual and neighborhood levels. This study is a population-based cross-sectional survey and is a part of the international research network Health Behavior in School-Aged Children (HBSC). Participants were 11-, 13- and 15-year-old Icelandic students present in their school at the day of administration (N = 9565, 50% males) in 156 compulsory schools. The results show that while family and friend support is associated with greater adolescent well-being, foreign-origin adolescents benefit more from supportive parents than native-origin adolescents. The study shows that belonging to an affluent family benefits well-being, as well as belonging to an affluent neighborhood. Closer inspection shows that this neighborhood effect benefits adolescents of foreign-origin less. More attention should be paid to useful and approachable resources in the environment of native and foreign-origin adolescents and ways to better mobilize the resources within families and neighborhoods.
Discriminative acoustic language recognition via channel-compensated GMM statistics

We propose a novel design for acoustic feature-based automatic spoken language recognizers. Our design is inspired by recent advances in text-independent speaker recognition, where intraclass variability is modeled by factor analysis in Gaussian mixture model (GMM) space. We use approximations to GMMlikelihoods which allow variable-length data sequences to be represented as statistics of fixed size. Our experiments on NIST LRE’07 show that variability-compensation of these statistics can reduce error-rates by a factor of three. Finally, we show that further improvements are possible with discriminative logistic regression training. Index Terms: acoustic language recognition, intersession variability compensation, discriminative training
The Quantum-Classical Transition as an Information Flow

We investigate the classical limit of the semiclassical evolution with reference to a well-known model that represents the interaction between matter and a given field. This is done by recourse to a special statistical quantifier called the "symbolic transfer entropy". We encounter that the quantum-classical transition gets thereby described as the sign-reversal of the dominating direction of the information flow between classical and quantal variables.
Strategies for transferring resistance into wheat: from wide crosses to GM cassettes

The domestication of wheat in the Fertile Crescent 10,000 years ago led to a genetic bottleneck. Modern agriculture has further narrowed the genetic base by introducing extreme levels of uniformity on a vast spatial and temporal scale. This reduction in genetic complexity renders the crop vulnerable to new and emerging pests and pathogens. The wild relatives of wheat represent an important source of genetic variation for disease resistance. For nearly a century farmers, breeders, and cytogeneticists have sought to access this variation for crop improvement. Several barriers restricting interspecies hybridization and introgression have been overcome, providing the opportunity to tap an extensive reservoir of genetic diversity. Resistance has been introgressed into wheat from at least 52 species from 13 genera, demonstrating the remarkable plasticity of the wheat genome and the importance of such natural variation in wheat breeding. Two main problems hinder the effective deployment of introgressed resistance genes for crop improvement: (1) the simultaneous introduction of genetically linked deleterious traits and (2) the rapid breakdown of resistance when deployed individually. In this review, we discuss how recent advances in molecular genomics are providing new opportunities to overcome these problems.
A dynamic and direct visualization model for the study of nasal airflow.

OBJECTIVE To evaluate nasal airflow characteristics during physiologic breathing in normal and pathologic conditions. DESIGN The choana of an anatomical human model was connected to a pump that simulated physiological pressure changes in the upper airway system. Normal ambient air was used as medium. The airstream was marked with aerosolized water particles, and was observed through an exact but translucent replica of the original nasal septum. RESULTS In physiologic conditions the airflow is mixed. Turbulence is clearly visible even with low flow velocities. There is less turbulence with lower flow rates. The nasal airflow follows a triphasic pattern of acceleration, near-steady state, and deceleration. Turbulence is prominent in the first and third phases. The main flow stream passes through the middle meatus at all rates. Hypertrophic mucosal membranes and turbinates increase the proportion of air passing the middle meatus. With decongested turbinates, flow distribution is more even. After turbinectomy there is a significant amount of airflow passing along the floor of the nose. The olfactory region is aerated only toward the end of inspiration and during the entire expiration phase. CONCLUSIONS This model allows the investigation of airflow distribution and turbulence under physiologic conditions and the examination of the influence of pathologic conditions on these parameters. Overzealous trimming of turbinates results in an unphysiologic distribution of airflow.
Experiences of Pretenure Counseling Professor Mothers

Researchers have identified some of the factors that inhibit the success of mothers in academia, including overt and covert discrimination, inequitable teaching and service assignments, and the lack of policies that support combining motherhood and academic work. Pretenure mothers are particularly vulnerable, as they attempt to balance increasing demands for achieving tenure and the overlap of the tenure and biological clocks. In addition to further exploring these factors, this phenomenological study of 10 women counseling professors considered the impact of rising cultural expectations related to motherhood. Results of this study revealed that combining pretenure academic work and motherhood seems to be increasingly more challenging. Themes highlighted include instances of incompatibility in academic and motherhood roles and barriers in academic culture. Also provided are positive aspects of academic motherhood, strategies for success under current cultural and academic systems, and suggestions for advocacy efforts to further support faculty mothers.
Antibody Response to Live Attenuated Vaccines in Adults in Japan

Abstract The purpose of this study was to examine the efficacy rendered with a single dose of live attenuated measles, rubella, mumps, and varicella containing vaccine. We inoculated healthcare workers (HCWs) with a single dose of vaccine to a disease lacking in antibody titer for those not meeting the criteria of our hospital (measles: <16.0 (IgG enzyme immunoassay (EIA)), rubella: ≤1:32 (hemagglutination-inhibition), mumps: <4.0 (IgG EIA), and varicella: <4.0 (IgG EIA)). At 28–60 days after vaccination, the antibody titer was tested again. We included 48 HCWs. A total of 32, 15, 31, and 10 individuals were inoculated with a single dose of measles-containing, rubella-containing, mumps, or varicella vaccine, respectively, and showed significant antibody elevation (9.2 ± 12.3 to 27.6 ± 215.6, p<0.001; 8 ± 1.2 to 32 ± 65.5, p<0.001; 3.0 ± 1.0 to 13.1 ± 8.6, p<0.05; and 2.6 ± 1.3 to 11.8 ± 8.1, p<0.001, respectively). Major side effects were not observed. In a limited population, a single dose of live attenuated vaccine showed elevation of antibody titer without any severe adverse reactions. However, whether the post-vaccination response rate criteria of our university was fulfilled could not be determined owing to limited sample size.
Impact of Identification and Treatment of Depression in Heart Transplant Patients

Background. The effects of clinical depression after orthotopic heart transplantation (OHT) are relatively unknown. The purpose of this study was to evaluate the impact of depression on outcomes after OHT. Methods. We performed a single center retrospective review of 102 consecutive patients who underwent OHT at Northwestern Memorial Hospital from June 2005 to October 2009. The diagnosis of depression was obtained from attending physician documentation. The primary endpoints were all-cause mortality (ACM), hospitalizations, and rejection. Results. Of 102 OHT patients, 26 (26%) had depression. Depressed patients were similar in age to nondepressed patients (57.6 years versus 56.9, P = 0.79). There was no statistical difference in survival between groups at 5 years after OHT (P = 0.94). All-cause hospitalizations were higher in depressed versus nondepressed patients (4.3 versus 2.6 hospitalizations P = 0.05). There were no significant differences in hospitalizations between the two groups for the following complications: cardiac (heart failure, edema, arrhythmias, and acute rejection) and infections. There was no significant difference in episodes of 2R and 3R rejection. Conclusion. Early identification and treatment of depression in OHT patients result in outcomes similar to nondepressed patients.
Separase cooperates with Zds1 and Zds2 to activate Cdc14 phosphatase in early anaphase

Completion of mitotic exit and cytokinesis requires the inactivation of mitotic cyclin-dependent kinase (Cdk) activity. A key enzyme that counteracts Cdk during budding yeast mitotic exit is the Cdc14 phosphatase. Cdc14 is inactive for much of the cell cycle, sequestered by its inhibitor Net1 in the nucleolus. At anaphase onset, separase-dependent down-regulation of PP2ACdc55 allows phosphorylation of Net1 and consequent Cdc14 release. How separase causes PP2ACdc55 down-regulation is not known. Here, we show that two Cdc55-interacting proteins, Zds1 and Zds2, contribute to timely Cdc14 activation during mitotic exit. Zds1 and Zds2 are required downstream of separase to facilitate nucleolar Cdc14 release. Ectopic Zds1 expression in turn is sufficient to down-regulate PP2ACdc55 and promote Net1 phosphorylation. These findings identify Zds1 and Zds2 as new components of the mitotic exit machinery, involved in activation of the Cdc14 phosphatase at anaphase onset. Our results suggest that these proteins may act as separase-regulated PP2ACdc55 inhibitors.