Miracle-dz/UniFAR-FTUs huggingface dataset:
Adoption of CRM technology in multichannel environment: a review (2006-2010)

Purpose – The purpose of this paper is to review state‐of‐art literature on adoption of CRM technology, including the CRM in multichannel environment and provide a comprehensive view of insights gained in this area of research through the bibliography.Design/methodology/approach – All together, nine databases were searched on the basis of four main descriptors which provided identification of 812 articles. A close review of the abstracts of these articles led to selection of 123 articles which were found relevant. Each of these articles was further reviewed and classified based on the main channel of CRM implementation. The articles were further classified in sub‐categories under each main channel theme.Findings – The selected articles were categorized under four main themes based on the channel – CRM, multichannel CRM, eCRM, mCRM. The articles in the CRM category were mainly focused on the strategic alignment along with research on increasing customer loyalty and use of data mining in CRM. Under the mult.
Hand Preference during Tool Use in Wild Bearded Capuchins

The preferential use of one limb (lateralization) has been observed in many species. This lateralization reflects functional asymmetries of the brain. Right-handedness and left-hemisphere dominance seem to be the norm in humans. However, suggestions that vertebrates, particularly non-human primates, show handedness are contentious. Tool use could be a driver of handedness. Here I investigated hand bias during tool use activities in groups of wild capuchins (Sapajus libidinosus). I observed the use of feeding tools in wild capuchin monkeys living in the dry Caatinga forests of the Serra da Capivara National Park, Piaui, Brazil. Capuchins used three major types of feeding tools: (a) tools for probing; (b) tools for pounding/cracking, and (c) digging stones to extract tubers or roots. I recorded hand use in 118 tool use bouts. These different types of tools had different motor demands; digging tools apparently favour right-hand use. The harsh Caatinga habitat poses a strong selective pressure for tool using, which might favour increased laterality and right-hand bias. However, the extent of right-handedness associated with tool use, particularly for digging, can only be fully evaluated following studies with larger sample sizes.
On the Right Objectives of Data Flow Testing

This paper investigates the limits of current data flow testing approaches from a radically novel viewpoint, and shows that the static data flow techniques used so far in data flow testing to identify the test objectives fail to represent the universe of data flow relations entailed by a program. This paper compares the data flow relations computed with static data flow approaches with the ones observed while executing the program. To this end, the paper introduces a dynamic data flow technique that collects the data flow relations observed during testing. The experimental data discussed in the paper suggest that data flow testing based on static techniques misses many data flow test objectives, and indicate that the amount of missing objectives (false negatives) can be more limiting than the amount of infeasible data flow relations identified statically (false positives). This opens a new area of research of (dynamic) data flow testing techniques that can better encompass the test objectives of data flow testing.
Field-induced quantum critical route to a Fermi liquid in high-temperature superconductors

In high-transition-temperature (Tc) superconductivity, charge doping is a natural tuning parameter that takes copper oxides from the antiferromagnet to the superconducting region. In the metallic state above Tc, the standard Landau's Fermi-liquid theory of metals as typified by the temperature squared (T2) dependence of resistivity appears to break down. Whether the origin of the non-Fermi-liquid behavior is related to physics specific to the cuprates is a fundamental question still under debate. We uncover a transformation from the non-Fermi-liquid state to a standard Fermi-liquid state driven not by doping but by magnetic field in the overdoped high-Tc superconductor Tl2Ba2CuO6+x. From the c-axis resistivity measured up to 45 T, we show that the Fermi-liquid features appear above a sufficiently high field that decreases linearly with temperature and lands at a quantum critical point near the superconductivity's upper critical field—with the Fermi-liquid coefficient of the T2 dependence showing a power-law diverging behavior on the approach to the critical point. This field-induced quantum criticality bears a striking resemblance to that in quasi-two-dimensional heavy-Fermion superconductors, suggesting a common underlying spin-related physics in these superconductors with strong electron correlations.
Serum uric acid and non-alcoholic fatty liver disease in non-hypertensive Chinese adults: the Cardiometabolic Risk in Chinese (CRC) study.

OBJECTIVE The causal relationship between serum uric acid (SUA) level and non-alcoholic fatty liver disease (NAFLD) has not yet been clarified. The objective of the study was to determine the association between SUA and NAFLD, as well as assess the interactions between SUA and other metabolic risk factors regarding NAFLD. PATIENTS AND METHODS The study samples related to a community-based health examination survey conducted in Central China. Initially, a total of 24,878 patients with medical examination were included. After excluding the individuals with confounding factors, the remaining 21,798 subjects with biomarkers available were included in the present study. RESULTS The data show that the risk of NAFLD significantly increased with the elevated SUA levels. Further adjustments for sex, age, and other confounding metabolic factors did not change the increasing trend of NAFLD risk. The odds ratios [ORs, 95% confidence interval (CI)] of NAFLD across the increasing quintiles of SUA were 1.00, 1,530 (1.174-1.995), 2.24 (1.714-2.886), 2.636 (2.019-3.441), and 3.714 (2.828-4.877) (p for trend < 0.0001). Also, significant interaction was found between SUA and prehypertension in relation to the NAFLD risk (p for interaction < 0.05). CONCLUSIONS SUA was significantly associated with NAFLD risk, independent of other metabolic risk factors, and SUA also had significant interaction with prehypertension regarding the risk of NAFLD.
Identification of the DNA-binding site for the phosphorylated VanR protein required for vancomycin resistance in Enterococcus faecium.

The vancomycin resistance operon of Enterococcus faecium encodes a two-component regulatory system comprising VanS and VanR. In vitro experiments showed that about 5% of a labile phosphorylated VanR (P-VanR) was accumulated from ATP and a maltose-binding protein-VanS fusion protein (MBP-VanS). Alternatively, about an 8% abundance of P-VanR was produced with acetyl phosphate. In such incubations, gel shift experiments revealed that P-VanR selectively bound to a 254-bp DNA fragment that contains the vanH promoter for the vanH, vanA, and vanX structural genes. When VanS was added with a mole ratio for VanS:VanR of higher than 1:1, VanS competed with DNA for P-VanR and abolished the gel shift. P-VanR bound 500-fold more tightly to the vanH promoter region, with an estimated EC50 of 40 nM, than the unphosphorylated VanR. A second DNA fragment of 197 bp containing the proposed vanR promoter for the vanR and vanS regulatory genes also exhibited gel shift, but with much lower affinities. A mutant VanR(D53A) was shown to be incompetent for phosphorylation by phosphorylated MBP-VanS or by acetyl phosphate; however, it still bound DNA specifically, albeit with low affinity. DNase I footprinting by P-VanR revealed that a ca. 80-bp region was protected on the vanH promoter and a ca. 40-bp region was protected on the vanR promoter. The unphosphorylated VanR footprinted the same 80 bp on the vanH promoter, but only 20 bp on the vanR promoter. (ABSTRACT TRUNCATED AT 250 WORDS)
Glucose triggers different global responses in yeast, depending on the strength of the signal, and transiently stabilizes ribosomal protein mRNAs

Glucose exerts profound effects upon yeast physiology. In general, the effects of high glucose concentrations (>1%) upon Saccharomyces cerevisiae have been studied. In this paper, we have characterized the global responses of yeast cells to very low (0.01%), low (0.1%) and high glucose signals (1.0%) by transcript profiling. We show that yeast is more sensitive to very low glucose signals than was previously thought, and that yeast displays different responses to these different glucose signals. Genes involved in central metabolic pathways respond rapidly to very low glucose signals, whereas genes involved in the biogenesis of cytoplasmic ribosomes generally respond only to glucose concentrations of> 0.1%. We also show that cytoplasmic ribosomal protein mRNAs are transiently stabilized by glucose, indicating that both transcriptional and post‐transcriptional mechanisms combine to accelerate the accumulation of ribosomal protein mRNAs. Presumably, this facilitates rapid ribosome biogenesis after exposure to glucose. However, our data indicate that yeast activates ribosome biogenesis only when sufficient glucose is available to make this metabolic investment worthwhile. In contrast, the regulation of metabolic functions in response to very low glucose signals presumably ensures that yeast can exploit even minute amounts of this preferred nutrient.
Alpha-methyl-l-tryptophan PET detects epileptogenic cortex in children with intractable epilepsy

Background: In children with tuberous sclerosis, the PET tracer α[11C]methyl-l-tryptophan (AMT) has been shown to be selectively taken up by epileptogenic tubers, thus allowing differentiation from nonepileptogenic tubers in the interictal state. Objective: To determine whether cortical areas showing increased AMT uptake in children without tuberous sclerosis complex with intractable neocortical epilepsy indicate the epileptogenic zone, and to assess the relative contributions of AMT and 2-deoxy-2[18F]fluoro-d-glucose (FDG) PET abnormalities to the localization of epileptogenic cortical regions. Methods: Areas of increased AMT and decreased FDG uptake were marked objectively as regions with abnormal asymmetry using an in-house written software in 27 children who underwent comprehensive evaluation for resective epilepsy surgery. The marked PET abnormalities were compared to the locations of scalp and subdural EEG epileptiform abnormalities, as well as histology and surgical outcome. Results: Focal cortical increases of AMT uptake were found in 15 patients. The lobar sensitivity (39.0%) of AMT PET for seizure onset was lower, but its specificity (100%) was higher (p < 0.0001) than that of hypometabolism on FDG PET (sensitivity 73.2%, specificity 62.7%). AMT PET abnormalities were smaller than corresponding FDG PET hypometabolic regions (p = 0.002), and increased AMT uptake occurred in two patients with nonlocalizing FDG PET. Histologically verified cortical developmental malformations were associated with increased AMT uptake (p = 0.044). Subdural electrodes adjacent to the area of increased AMT uptake were most often involved in seizure onset. Conclusions: Focal increase of cortical AMT uptake in children is less sensitive but more specific for the lobe of seizure onset than corresponding FDG PET hypometabolism, and it is often associated with epileptogenic cortical developmental malformations. AMT PET can assist placement of subdural electrodes even when MRI and FDG PET fail to provide adequate localizing information. Cortical areas adjacent to increased AMT uptake should be carefully addressed by intracranial EEG because these regions often show a high degree of epileptogenicity.
Databases and Information Integration for the Medicago truncatula Genome and Transcriptome1

An international consortium is sequencing the euchromatic genespace of Medicago truncatula. Extensive bioinformatic and database resources support the marker-anchored bacterial artificial chromosome (BAC) sequencing strategy. Existing physical and genetic maps and deep BAC-end sequencing help to guide the sequencing effort, while EST databases provide essential resources for genome annotation as well as transcriptome characterization and microarray design. Finished BAC sequences are joined into overlapping sequence assemblies and undergo an automated annotation process that integrates ab initio predictions with EST, protein, and other recognizable features. Because of the sequencing project's international and collaborative nature, data production, storage, and visualization tools are broadly distributed. This paper describes databases and Web resources for the project, which provide support for physical and genetic maps, genome sequence assembly, gene prediction, and integration of EST data. A central project Web site at medicago.org/genome provides access to genome viewers and other resources project-wide, including an Ensembl implementation at medicago.org, physical map and marker resources at mtgenome.ucdavis. edu, and genome viewers at the University of Oklahoma (www.genome.ou.edu), the Institute for Genomic Research (www.tigr.org), and Munich Information for Protein Sequences Center (mips.gsf.de).
Structural and functional characterization of dog heart microsomes.

Several procedures for the preparation of microsomes from heart tissue were compared. Sucrose was found the most effective addition to preserve the activity of the sarcoplasmic reticulum vesicles. Electron microscopy of sectioned pellets shows uniform vesicles, but negative staining of microsomal suspensions allows recognition of mitochondrial fragments, which are found in cardiac microsomal fractions in greater amounts than in skeletal muscle preparations. The quantity of mitochondrial contaminations in different fractions was estimated by measuring enzymatic activities. A comparison of Ca2+ accumulation, Ca2+ efflux, and ATPase activity shows identical features in preparations from the heart and from skeletal muscle, although the specific activity is approximately ten times lower in those from the heart. The apparent affinity of sarcoplasmic reticulum for Ca2+ in vitro justifies the assumption that sarcoplasmic reticulum lowers the intracellular Ca2+ concentration in the in-vivo heart below the level required for contraction. However, in a weight unit of fresh tissue, the ratio between the maximal Ca2+ accumulated by SR and the amount of contractile protein is much lower in the heart than in skeletal muscle. Caffeine and, more markedly, propranolol and tetracaine increase efflux of accumulated Ca2+ and thereby reduce net uptake by fragmented sarcoplasmic reticulum. Isopropylmethoxamine is not effective at millimolar concentrations.
Multi-resolution model transmission in distributed virtual environments

Distributed virtual environments allow users at different geographical locations to share and interact within a common virtual environment via a local network or through the Internet. To deliver a good performance for such applications, we need to address several issues in different research disciplines. First, we must be able to model virtual objects effectively. The recently developed multi-resolution techniques for object modeling are of great value here, since they are capable of simplifying the object models and therefore reducing the time to render them. This may greatly reduce the demand for rendering performance on the client machines. Second, with the constraint of the limited bandwidth of the Internet, we need to reduce the response time by reducing the amount of data requested over the network. Caching of suitable object models of high affinity will reduce the amount of data requested over the network for a faster response time. Prefetching object models by predicting those which are likely to be used in the near future and downloading them in advance will lead to a similar improvement. Third, the Internet often suffers from disconnection. A caching mechanism that allows objects to be cached with at least their minimum resolutions will be useful to provide at least a coarse view of the objects to the viewer for improved visual perception. In this paper, we describe our implementation of a distributed walkthrough system. Two techniques are fundamental to our system, a mu&-resolzltzon caching mechanism and a set of object prefetching mechanisms. Towards the end of the paper, we quantify the performance of t,he proposed mechanisms.
Modeling of Passive Forces of Machine Tool Covers

The passive forces acting against the drive force are phenomena that influence dynamical properties and precision of linear axes equipped with feed drives. Covers are one of important sources of passive forces in machine tools. The paper describes virtual evaluation of cover passive forces using the cover complex model. The model is able to compute interaction between flexible cover segments and sealing wiper. The result is deformation of cover segments and wipers which is used together with measured friction coefficient for computation of cover total passive force. This resulting passive force is dependent on cover position. Comparison of computational results and measurement on the real cover is presented in the paper.
Extracting epidemiologic exposure and outcome terms from literature using machine learning approaches

Much epidemiologic information resides in literature, which is not in a computable format. To extract information and build knowledge bases of epidemiologic studies, we developed a system to extract noun phrases about epidemiologic exposures and outcomes. The system consists of two components: a natural language processing (NLP) engine; a machine learning (ML) based classifier. Four ML algorithms were applied and compared over different feature sets. To evaluate the performance of the system, we manually constructed an annotated dataset. The system achieved the highest F-measure of 82.0% for extracting exposure terms, and 70% for extracting outcome terms.
Recognising “success” and “failure”: evaluating groupware in a commercial context

This paper reports on the installation and use of two commercial ‘groupware’ systems, a videolink and electronic document exchange, in a major clearing bank in the UK. It suggests some of the complexities involved in evaluating groupware in a business such that recognising and understanding even such gross terms as ‘success’ and ‘failure’ is far from easy. Consequently it argues that a more nuanced appreciation of success and failure needs to be developed and, therefore, some form of ethnographic, ‘illuminative’ evaluation may prove commercially worthwhile.
Additional Routes to Staphylococcus aureus Daptomycin Resistance as Revealed by Comparative Genome Sequencing, Transcriptional Profiling, and Phenotypic Studies

Daptomycin is an extensively used anti-staphylococcal agent due to the rise in methicillin-resistant Staphylococcus aureus, but the mechanism(s) of resistance is poorly understood. Comparative genome sequencing, transcriptomics, ultrastructure, and cell envelope studies were carried out on two relatively higher level (4 and 8 µg/ml−1) laboratory-derived daptomycin-resistant strains (strains CB1541 and CB1540 respectively) compared to their parent strain (CB1118; MW2). Several mutations were found in the strains. Both strains had the same mutations in the two-component system genes walK and agrA. In strain CB1540 mutations were also detected in the ribose phosphate pyrophosphokinase (prs) and polyribonucleotide nucleotidyltransferase genes (pnpA), a hypothetical protein gene, and in an intergenic region. In strain CB1541 there were mutations in clpP, an ATP-dependent protease, and two different hypothetical protein genes. The strain CB1540 transcriptome was characterized by upregulation of cap (capsule) operon genes, genes involved in the accumulation of the compatible solute glycine betaine, ure genes of the urease operon, and mscL encoding a mechanosensitive chanel. Downregulated genes included smpB, femAB and femH involved in the formation of the pentaglycine interpeptide bridge, genes involved in protein synthesis and fermentation, and spa encoding protein A. Genes altered in their expression common to both transcriptomes included some involved in glycine betaine accumulation, mscL, ure genes, femH, spa and smpB. However, the CB1541 transcriptome was further characterized by upregulation of various heat shock chaperone and protease genes, consistent with a mutation in clpP, and lytM and sceD. Both strains showed slow growth, and strongly decreased autolytic activity that appeared to be mainly due to decreased autolysin production. In contrast to previous common findings, we did not find any mutations in phospholipid biosynthesis genes, and it appears there are multiple pathways to and factors in daptomycin resistance.
[The relationship between burnout, personal traits, and the work environment of caregivers in group homes].

OBJECTIVES This study aimed to identify the relationship between burnout, personal traits, work environment, and the stress coping skills of caregivers in group homes (GH) for elderly patients with dementia. METHODS An anonymous, self-administered questionnaire was distributed to 600 caregivers working in 47 GH in Fukuoka Prefecture. Three hundred and thirty-three responses were analyzed. The questionnaire gathered information on burnout, personal traits, work environment, and stress coping skills. The modified Japanese version of the Maslach Burnout Inventory (MBI) was applied. RESULTS The mean age of the subjects was 42.5 years. The 2 main employment statuses were full-time worker (75.4%) and temporary worker (22.8%). The annual income of 178 (53.5%) subjects was less than 2 million yen. Most of them (80%) harbored job insecurity with regard to the future. The mean scores for 3 MBI elements-emotional exhaustion, depersonalization, and reduced personal accomplishment-were 14.3, 11.2, and 16.1, respectively. After adjusting for personal traits and work environment, burnout was found to be significantly associated with the difficulties perceived by caregivers, and was composed of 4 factors: conflict with the GH residents, support system at the workplace, conflict among staff members, and a sense of being burdened. The elements of emotional exhaustion and depersonalization were also related to the subjects, while the element of reduced accomplishment was related to their active coping levels. CONCLUSION The burnout status of caregivers in GH is associated with their perceived difficulties in daily care work. This finding suggests that these caregivers require individual support to cope with the difficulties involved in their daily care work as well as to improve their work environment.