Miracle-dz/UniFAR-FTUs huggingface dataset:
Identification of Neurotensin Receptor Expressing Cells in the Ventral Tegmental Area across the Lifespan

Abstract Neurotensin (Nts) promotes activation of dopamine (DA) neurons in the ventral tegmental area (VTA) via incompletely understood mechanisms. Nts can signal via the G protein-coupled Nts receptors 1 and 2 (NtsR1 and NtsR2), but the lack of methods to detect NtsR1- and NtsR2-expressing cells has limited mechanistic understanding of Nts action. To overcome this challenge, we generated dual recombinase mice that express FlpO-dependent Cre recombinase in NtsR1 or NtsR2 cells. This strategy permitted temporal control over recombination, such that we could identify NtsR1- or NtsR2-expressing cells and determine whether their distributions differed between the developing and adult brain. Using this system, we found that NtsR1 is transiently expressed in nearly all DA neurons and in many non-DA neurons in the VTA during development. However, NtsR1 expression is more restricted within the adult brain, where only two thirds of VTA DA neurons expressed NtsR1. By contrast, NtsR2 expression remains constant throughout lifespan, but it is predominantly expressed within glia. Anterograde tract tracing revealed that NtsR1 is expressed by mesolimbic, not mesocortical DA neurons, suggesting that VTA NtsR1 neurons may represent a functionally unique subset of VTA DA neurons. Collectively, this work reveals a cellular mechanism by which Nts can directly engage NtsR1-expressing DA neurons to modify DA signaling. Going forward, the dual recombinase strategy developed here will be useful to selectively modulate NtsR1- and NtsR2-expressing cells and to parse their contributions to Nts-mediated behaviors.
Age Diversity Among Victims of Hebephilic Sexual Offenders

Hebephilia refers to sexual interest in pubescent children who are beginning to show early signs of sexual development but are sexually immature. The present study examined the relationship between hebephilia and victim age choice in a sample of 2,238 adult male sexual offenders. On average, offenders were 39 years old at the time of their assessments, and approximately half (48%) were referred by probation or parole offices. Assessment data included self-report, sexual arousal measured by volumetric phallometry, and victims’ ages. Results suggested that, similar to pedophilia, hebephilia had a medium sized association with a greater number of victims under age 11 and a small sized association with a greater number of victims ages 11 to 14. Unlike pedophilia, a small positive association was consistently found between hebephilia and a greater number of victims ages 15 or 16. Furthermore, a small positive association was observed between victim age polymorphism and hebephilia and pedophilia. The present results suggested that hebephilia was associated with a greater number of victims age 14 or younger and had similar victim age correlates to pedophiles.
Entrepreneurial Finance with Equity-for-Guarantee Swap and Idiosyncratic Risk

We consider a risk-averse entrepreneur who invests in a project with idiosyncratic risk. In contrast to the literature, we assume the entrepreneur is unable to get a loan from a bank directly because of the low creditability of the entrepreneur and so an innovative financial contract, named equity-for-guarantee swap, is signed among a bank, an insurer, and the entrepreneur. It is shown that the new swap leads to higher leverage, which brings more diversification and tax benefits. The new swap not only solves the problems of financing constraints, but also significantly improves the welfare level of the entrepreneur. The growth of welfare level increases dramatically with risk aversion index and the volatility of idiosyncratic risk.
Clearance of topically-applied PVP-iodine as a solution or gel in periodontal pockets in men

Abstract Objectives. The aim of the study was to investigate the clearance of PVP-iodine applied as a gel or solution in periodontal pockets. Methods. Teeth of 12 subjects with at least eight periodontal pockets of ≥5 mm probing depth were isolated with a rubber dam to allow contamination-free access to the pockets. In each subject, three pockets were filled with PVP-iodine gel (10%) and three with PVP-iodine solution (10%). One pocket of each subject without iodine application served as a negative control. The treatment allocation was assigned randomly. Any excess material was removed subsequently. After 1, 5 and 15 min, a paper point was used to collect the sulcus liquid and the concentration of PVP-iodine was chemically determined. In addition, PVP-iodine gel was administered into 12 periodontal pockets immediately after sub-gingival ultrasound debridement and the concentration of PVP-iodine was determined after 1 min. Results. Descending concentrations of PVP-iodine were determined at 1, 5 and 15 min after the application. No PVP-iodine was found in the pockets serving as negative controls. The mean concentrations of the gel and solution were 6.14 μg/ml and 4.44 μg/ml (1 min; p ≥ 0.028), 3.20 μg/ml and 1.44 μg/ml (5 min; p ≥ 0.126), 0.69 μg/ml and 0.23 μg/ml (15 min; p ≤ 0.019), respectively. In the pockets with previous debridement the mean concentration was 1.68 ± 1.97 μg/ml. Conclusion. The application of PVP-iodine gel in periodontal pockets allows a prolonged remnant effect as compared to that of the solution formula.
Severely Affected by Parkinson Disease: The Patient’s View and Implications for Palliative Care

Introduction: People severely affected by Parkinson disease (PD)/atypical parkinsonism (AP) comprise a heterogeneous group with distinct needs, which so far remain largely unexamined. The aim of our study was to analyze reasons for feeling severely affected and document unmet needs in a patient subgroup severely affected by PD/AP using solely a subjective inclusion criterion. Methods: Patients feeling severely affected by PD/AP were recruited via a magazine published by the German Parkinson Association. A questionnaire was sent out nationwide. Besides analyzing the closed-ended questions, a subsample of 40% was analyzed regarding the open-ended questions using content analysis. Correlations between subjectively felt severe affectedness and objective criteria were calculated. Results: Eight hundred fourteen questionnaires were analyzed. Sample characteristics were: mean age 70 years; 60.3% male; time since diagnosis up to 37 years; and Hoehn and Yahr score (if known) 3 (44.6%), followed by 4 (23.9%). Significant associations were observed between subjectively felt severe affectedness and Hoehn and Yahr (P ≤ .05), poorer health ( P ≤ .01), higher nursing care level (P ≤ 0.01), and having no children ( P ≤ .05). Most common reasons for feeling severely affected were mobility impairment (34.9%), coordination problems (17.0%), speech problems (12.2%), and limited day-to-day activities (7.8%). Most often expressed unmet needs were support in everyday life (28.1%), medical treatment (15.2%), help with financial services (11.6%), and social integration (9.9%). Conclusions: To meet the complex needs, an integrated multidisciplinary and multiprofessional approach is indicated befitting palliative care principles. Herein, home-based services seem of special importance for patients in advanced disease stages.
Transphyseal involvement of pyogenic osteomyelitis is considerably more common than classically taught.

OBJECTIVE Radiologists are taught that pyogenic osteomyelitis in children rarely crosses the growth plate because terminal vessels of nutrient arteries loop at the physis, predisposing the metaphysis to hematogenous infection. However, we note that MRI frequently shows osteomyelitis involving both sides of the physis. The purpose of this article is to document our observation that pyogenic osteomyelitis crosses the growth plate more frequently in the pediatric patient population than is classically taught. MATERIALS AND METHODS All pediatric patients (age, 2-16 years) with clinically suspected osteomyelitis from 2004 to 2009 were reviewed for transphyseal disease on a consensus basis. To reveal the statistical significance, we applied a z test to our results. We quantified rare as 20% or less and used a z test to determine whether 27 of 32 (81%) differed from rare. RESULTS Of 32 subjects, 81% showed transphyseal infection. In our study, the z test revealed that transphyseal infection occurred significantly more often than what would be considered rare (z = 4.75, p < 0.01). CONCLUSION In our pediatric patient population, we have documented a higher frequency of transphyseal osteomyelitis (81%) than metaphyseal osteomyelitis in pyogenic infections. When our findings are statistically compared with an expected rate of 20%, they cannot be attributed to chance alone. This raises some doubt regarding the conventional understanding of pediatric pyogenic osteomyelitis.
Damping properties of fiber reinforced composite suitable for stayed cable

Carbon fiber reinforced plastics (CFRP) cables were initially most investigated to replace steel cables. To further explore the advantages of FRP cables, the potential ability of vibration control is studied in this paper emphasizing the designable characteristic of hybrid FRP cables. Fiber reinforced vinyl ester composites and fiber reinforced epoxy composites were prepared by the pultrusion method. Due to the extensive application of fiber reinforced composites, the temperature spectrum and frequency spectrum of loss factor for the composite were tested using dynamic mechanical analysis (DMA) equipment. The damping properties and damping mechanism of the composite were investigated and discussed at different temperatures and frequencies. The result indicates that the loss factor of the composites is increasing with the increase of the frequency from 0.1Hz to 2 Hz and decreasing with the decrease of the temperature from -20°C to 60°C. The loss factor of the carbon fiber composite is higher than that of the glass fiber for the same matrix. The loss factor of the vinyl ester composite is higher than that of the epoxy composite for the same fiber.
EmoTxt: A toolkit for emotion recognition from text

We present EmoTxt, a toolkit for emotion recognition from text, trained and tested on a gold standard of about 9K question, answers, and comments from online interactions. We provide empirical evidence of the performance of EmoTxt. To the best of our knowledge, EmoTxt is the first open-source toolkit supporting both emotion recognition from text and training of custom emotion classification models.
Linear Viscoelastic Properties of Bituminous Materials Including New Products Made with Ultrafine Particles

ABSTRACT An experimental campaign has been performed at the ENTPE laboratory in order to measure the linear viscoelastic properties (shear complex modulus G*) of mastics with a specifically developed device (annular shear rheometer). Different fillers have been used to design mastics, among which a new type of filler only composed of ultrafine particles. The use of these ultrafine particles induces a significant increase in the complex modulus of mastics at high temperature in comparison to mastics with classical fillers. The potential for reinforcement of fillers is quantified by the complex reinforcement coefficient RM* introduced in this paper. The ultrafine particles have also been used in bituminous mixtures. As it is observed for mastics, an important increase of the modulus is observed at high temperature for the mixtures made with ultrafine filler. Finally, simulations of the linear viscoelastic behaviour of bituminous materials with 2S2P1D model developed at the ENTPE are proposed. Simulations fit quite well experimental results.
Detecting Semantic Parts on Partially Occluded Objects

In this paper, we address the task of detecting semantic parts on partially occluded objects. We consider a scenario where the model is trained using non-occluded images but tested on occluded images. The motivation is that there are infinite number of occlusion patterns in real world, which cannot be fully covered in the training data. So the models should be inherently robust and adaptive to occlusions instead of fitting / learning the occlusion patterns in the training data. Our approach detects semantic parts by accumulating the confidence of local visual cues. Specifically, the method uses a simple voting method, based on log-likelihood ratio tests and spatial constraints, to combine the evidence of local cues. These cues are called visual concepts, which are derived by clustering the internal states of deep networks. We evaluate our voting scheme on the VehicleSemanticPart dataset with dense part annotations. We randomly place two, three or four irrelevant objects onto the target object to generate testing images with various occlusions. Experiments show that our algorithm outperforms several competitors in semantic part detection when occlusions are present.
Rhinitis, sinusitis, and upper airway disease Influence of seasonal exposure to grass pollen on local and peripheral blood IgE repertoires in patients with allergic rhinitis

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Pop-in events induced by spherical indentation in compound semiconductors

Details of the elastic–plastic transitions in crystalline compound semiconductors have been examined using spherical indentation. Two cubic (InP and GaAs) and two hexagonally structured semiconductors (ZnO and GaN) have been studied. A series of indentations have been made in each material at a number of different loads. The resulting load–penetration curves exhibited one or more discontinuities on loading (so called pop-in events). The load at which the initial pop-in event occurred has been measured along with the corresponding indenter extension. The elastic and elastic–plastic response of each material to spherical indentation has been calculated and compared with the experiment. By taking the difference between the elastic and elastic–plastic penetration depths, it has been found that the pop-in extension at each load could be predicted for each material. The detailed deformation behavior of each of the materials during indentation has also been discussed.
Intraocular Pressure Measurements Referring to the Corneal Thickness in Keratoconic Eyes After Corneal Crosslinking with Riboflavin and Ultraviolet A

Aim: To determine the possible relation between intraocular pressure (IOP), central corneal thickness (CCT) and corneal resistance (CR) in kerotoconic eyes before, 3,6 and 12 months after collagen crosslinking procedure (CXL) with aim to find out does the thicker cornea means already more resistance cornea followed with higher IOP. Methods: Thirty eyes (30 patients) with central keratoconus (KC)were evaluated in retrospective cross sectional study. The corneal biomechanical parameters were taken with Wave Light Allegro Oculyzer produced by Alcon before the CXL, 3, 6 and 12 months after the procedure. IOP were checked by Goldmann applanation tonometry (GAT) before, 3, 6 and 12 months after CXL. Results: The value of IOP before the CXL was 12,0 mmHg (10,62-15,25 mmHg), 3 months later 13,5 mmHg (11,0-16,0 mmHg), 6 months 14,0 mmHg (11,0-16,0 mmHg) and 12 months later 15,0 mmHg (10,37-17,25 mmHg) and was statistically significant higher (p=0,015) comparing to the value of IOP 3 months after the CXL, IOP 12 months after CXL procedure was statistically significant higher comparing to preoperative values (p=0,010). There were no statistically significant difference between the values 3 and 6 months after CXL. The CCT before the CXL procedure was 449 (433-505,75 microns), 3 months after CXL was 420 (383-473microns, p < 0,005), 6 months later 437 (401,25-480,25, p=0,001), 12 months after CXL 437 (401-503 microns, p=0,001). However there is statistically significant difference in CCT 12 months after CXL 437 (401-503microns p=0,032) and the value of CCT 3 months later the procedure (p=0,004) and the CCT 12 months after CXL and the value of CXL 6 months after CXL (p=0,036). The value of CCT did not show any statistically significant difference 3 and 6 months postoperatively. Conclusion: After riboflavin-UVA CXL in eyes with KC there was significant decrease in central corneal thickness 3 and 6 months after the procedure and the thickness is almost the same 12 months later. However IOP is low before CXL, raising up 3 and 6 months after CXL but significant increase is seen 12 months later. It means the regular measurement of IOP could be the serious and confident indicator of increasing of corneal resistance which is the main goal of CXL treatment.
Effects of Fabric Parameters on Specular Reflection of Single-Jersey Knitted Fabrics

This paper is concerned with the prediction of goniophotometric curves (distribution curves of specularly reflected light) based on our mathematical model developed earlier for single-jersey knitted fabrics made from monofilament yarns. The theory is extended to include fabrics from multifilament yarns. Four physical and optical parameters related to the fabric and the light source are investigated: fiber refractive index, yarn cross section, incident light angle, and fiber ellipticity. Their effects on the goniophotometric curves and luster index of knitted fabrics are determined. In addition, the great difference is high lighted between light reflected from knitted fabrics and light received by the goniopho tometer.
Fast enumeration of maximal valid subgraphs for custom-instruction identification

Extensible processors are increasingly becoming popular as they allow for incorporating custom instructions to meet design constraints. However, identifying custom instructions under architectural input/output ports constraint is a time consuming process particularly when large applications are considered. To rapidly identify the most profitable custom instructions with large inputs and outputs, this paper proposes a novel identification algorithm for enumerating maximal convex subgraphs containing no invalid node (i.e., maximal valid subgraphs). The proposed enumerating strategy is based on divide-and-conquer with a top-down manner, rather than the bottom-up manner utilized in the state-of-the-art. The division operation only considers invalid inner nodes of the given DFG, rather than taking all the invalid nodes into account, and thus accelerates enumeration of the maximal valid subgraphs. Experimental results show that, the improvement over the latest work is more than 90% for 60% DFG instances of the acknowledged benchmarks.
Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake1234

Background: Macronutrient intake varies substantially between individuals, and there is evidence that this variation is partly accounted for by genetic variants. Objective: The objective of the study was to identify common genetic variants that are associated with macronutrient intake. Design: We performed 2-stage genome-wide association (GWA) meta-analysis of macronutrient intake in populations of European descent. Macronutrients were assessed by using food-frequency questionnaires and analyzed as percentages of total energy consumption from total fat, protein, and carbohydrate. From the discovery GWA (n = 38,360), 35 independent loci associated with macronutrient intake at P < 5 × 10−6 were identified and taken forward to replication in 3 additional cohorts (n = 33,533) from the DietGen Consortium. For one locus, fat mass obesity-associated protein (FTO), cohorts with Illumina MetaboChip genotype data (n = 7724) provided additional replication data. Results: A variant in the chromosome 19 locus (rs838145) was associated with higher carbohydrate (β ± SE: 0.25 ± 0.04%; P = 1.68 × 10−8) and lower fat (β ± SE: −0.21 ± 0.04%; P = 1.57 × 10−9) consumption. A candidate gene in this region, fibroblast growth factor 21 (FGF21), encodes a fibroblast growth factor involved in glucose and lipid metabolism. The variants in this locus were associated with circulating FGF21 protein concentrations (P < 0.05) but not mRNA concentrations in blood or brain. The body mass index (BMI)–increasing allele of the FTO variant (rs1421085) was associated with higher protein intake (β ± SE: 0.10 ± 0.02%; P = 9.96 × 10−10), independent of BMI (after adjustment for BMI, β ± SE: 0.08 ± 0.02%; P = 3.15 × 10−7). Conclusion: Our results indicate that variants in genes involved in nutrient metabolism and obesity are associated with macronutrient consumption in humans. Trials related to this study were registered at clinicaltrials.gov as NCT00005131 (Atherosclerosis Risk in Communities), NCT00005133 (Cardiovascular Health Study), NCT00005136 (Family Heart Study), NCT00005121 (Framingham Heart Study), NCT00083369 (Genetic and Environmental Determinants of Triglycerides), NCT01331512 (InCHIANTI Study), and NCT00005487 (Multi-Ethnic Study of Atherosclerosis).
A mendelian form of neural tube defect caused by a de novo null variant in SMARCC1 in an identical twin

Neural tube defects (NTDs) are among the most common birth defects in humans and yet their molecular etiology remains poorly understood. NTDs are believed to result from the complex interaction of environmental factors with a multitude of genetic risk factors in a classical multifactorial disease model. Mendelian forms of NTDs in which single variants are sufficient to cause the disease are extremely rare. We report a monozygotic twin with severe NTDs (occipital encephalocele and myelomeningocele) and a shared de novo, likely truncating, variant in SMARCC1. RTPCR analysis suggests the potential null nature of the variant attributed to nonsense‐mediated decay. SMARCC1 is extremely constrained in humans and encodes a highly conserved core chromatin remodeler, BAF155. Mice that are heterozygous for a null allele or homozygous for a hypomorphic allele develop severe NTDs in the form of exencephaly. This is the first report of SMARCC1 mutation in humans, and it shows a critical and conserved requirement for intact BAF chromatin remodeling complex in neurulation. Ann Neurol 2018;83:433–436