Miracle-dz/UniFAR-FTUs huggingface dataset:
Recent advances in cardiac catheterization for congenital heart disease

The field of pediatric and adult congenital cardiac catheterization has evolved rapidly in recent years. This review will focus on some of the newer endovascular technological and management strategies now being applied in the pediatric interventional laboratory. Emerging imaging techniques such as three-dimensional (3D) rotational angiography, multi-modal image fusion, 3D printing, and holographic imaging have the potential to enhance our understanding of complex congenital heart lesions for diagnostic or interventional purposes. While fluoroscopy and standard angiography remain procedural cornerstones, improved equipment design has allowed for effective radiation exposure reduction strategies. Innovations in device design and implantation techniques have enabled the application of percutaneous therapies in a wider range of patients, especially those with prohibitive surgical risk. For example, there is growing experience in transcatheter duct occlusion in symptomatic low-weight or premature infants and stent implantation into the right ventricular outflow tract or arterial duct in cyanotic neonates with duct-dependent pulmonary circulations. The application of percutaneous pulmonary valve implantation has been extended to a broader patient population with dysfunctional ‘native’ right ventricular outflow tracts and has spurred the development of novel techniques and devices to solve associated anatomic challenges. Finally, hybrid strategies, combining cardiosurgical and interventional approaches, have enhanced our capabilities to provide care for those with the most complex of lesions while optimizing efficacy and safety.
Interspecies characterization and tissue engineering of the temporomandibular joint disc

Interspecies Characterization and Tissue Engineering of the Temporomandibular Joint Disc By Kerem N. Kalpakci Disorders of the temporomandibular joint (TMJ) are widespread, afflicting millions of people. The majority of these cases involve displacement or injury to the TMJ disc. Current treatments do not fully address severe cases of TMJ dysfunction; therefore, efforts to engineer functional tissues for repair or replacement are warranted. While previous studies have laid the groundwork for these efforts, significant challenges remain, including (1) identification of appropriate animal models, (2) development of methodologies for in vitro TMJ tissue engineering, and (3) refinement of tissue culture procedures for clinically relevant cells sources. This thesis contributes to overcoming these challenges by (1) exploring topographical and interspecies variation in functional properties of the TMJ disc, (2) developing an in vitro tissue engineering strategy capable of recapitulating native tissue characteristics, and (3) enhancing protocols for chondrogenesis of dermis-derived cells. The first aim of this thesis characterized the biomechanical and biochemical properties of human TMJ disc in relation to several animal models. Significant regional and interspecies variations were indentified, though certain characteristics were observed across all species. While the human disc displayed properties distinct from the other species, the pig was the most similar and was therefore identified as the most appropriate animal model. The second aim applied these findings as design criteria in the development of an in vitro tissue engineering strategy. Scaffoldless constructs derived
Comparison of Performance Characteristics of American College of Radiology TI-RADS, Korean Society of Thyroid Radiology TIRADS, and American Thyroid Association Guidelines.

OBJECTIVE The American College of Radiology (ACR) Thyroid Imaging Reporting and Data System (TI-RADS) provides guidelines to practitioners who interpret sonographic examinations of thyroid nodules. The purpose of this study is to compare the ACR TI-RADS system with two other well-established guidelines. MATERIALS AND METHODS The ACR TI-RADS, the Korean Society of Thyroid Radiology (KSThR) Thyroid Imaging Reporting and Data System (TIRADS), and the American Thyroid Association guidelines were compared using 3422 thyroid nodules for which pathologic findings were available. The composition, echogenicity, margins, echogenic foci, and size of the nodules were assessed to determine whether a recommendation would be made for fine-needle aspiration or follow-up sonography when each system was used. The biopsy yield of malignant findings, the yield of follow-up, and the percentage of malignant and benign nodules that would be biopsied were determined for all nodules and for nodules 1 cm or larger. RESULTS The percentage of nodules that could not be classified was 0%, 3.9%, and 13.9% for the ACR TI-RADS, KSThR TIRADS, and ATA guidelines, respectively. The biopsy yield of malignancy was 14.2%, 10.2%, and 10.0% for nodules assessed by the ACR TI-RADS, KSThR TIRADS, and ATA guidelines, respectively. The percentage of malignant nodules that were biopsied was 68.2%, 78.7%, and 75.9% for the ACR TI-RADS, the KSThR TIRADS, and the ATA guidelines, respectively, whereas the percentage of malignant nodules that would be either biopsied or followed was 89.2% for the ACR TI-RADS. The percentage of benign nodules that would be biopsied was 47.1%, 79.7%, and 78.1% for the ACR TI-RADS, the KSThR TIRADS, and the ATA guidelines, respectively. The percentage of benign nodules that would be either biopsied or followed was 65.2% for the ACR TI-RADS. CONCLUSION The ACR TI-RADS performs well when compared with other well-established guidelines.
Improving College Instruction through Incentives

In a field experiment, we examine the impact of performance-based incentives for community college instructors. Instructor incentives improve student exam scores, course grades, and credit accumulation while reducing course dropout. Effects are largest among part-time adjunct instructors. During the program, instructor incentives have large positive spillovers, increasing completion rates and grades in students’ courses outside our study. One year after the program, instructor incentives increase transfer rates to 4-year colleges with no impact on 2-year college degrees. We find no evidence of complementarities between instructor incentives and student incentives. Finally, while instructors initially prefer gain-framed contracts over our loss-framed ones, preferences for loss-framed contracts significantly increase after experience with them.
DeModify: A Dataset for Analyzing Contextual Constraints on Modifier Deletion

Tasks such as knowledge extraction, text simpliﬁcation and summarization have in common the fact that from a text fragment a smaller (not necessarily contiguous) portion is obtained by discarding part of the context. This may cause the text fragment to acquire a new meaning, or even to become false. The smallest units that can be considered disposable in a larger context are modiﬁers. In this paper we describe a dataset collected and annotated to facilitate the study of the inﬂuence of modiﬁers on the meaning of the context they are part of, and to support the development of models that can determine whether a modiﬁer can be removed without undesirable semantic consequences.
Characterisation of insulin analogues therapeutically available to patients

The structure and function of clinical dosage insulin and its analogues were assessed. This included ‘native insulins’ (human recombinant, bovine, porcine), ‘fast-acting analogues’ (aspart, glulisine, lispro) and ‘slow-acting analogues’ (glargine, detemir, degludec). Analytical ultracentrifugation, both sedimentation velocity and equilibrium experiments, were employed to yield distributions of both molar mass and sedimentation coefficient of all nine insulins. Size exclusion chromatography, coupled to multi-angle light scattering, was also used to explore the function of these analogues. On ultracentrifugation analysis, the insulins under investigation were found to be in numerous conformational states, however the majority of insulins were present in a primarily hexameric conformation. This was true for all native insulins and two fast-acting analogues. However, glargine was present as a dimer, detemir was a multi-hexameric system, degludec was a dodecamer (di-hexamer) and glulisine was present as a dimer-hexamer-dihexamer system. However, size-exclusion chromatography showed that the two hexameric fast-acting analogues (aspart and lispro) dissociated into monomers and dimers due to the lack of zinc in the mobile phase. This comprehensive study is the first time all nine insulins have been characterised in this way, the first time that insulin detemir have been studied using analytical ultracentrifugation and the first time that insulins aspart and glulisine have been studied using sedimentation equilibrium. The structure and function of these clinically administered insulins is of critical importance and this research adds novel data to an otherwise complex functional physiological protein.
FLUORIDE CONTENT OF DAIRY MILK FROM SUPERMARKET A POSSIBLE CONTRIBUTING FACTOR TO DENTAL FLUOROSIS

SUMMARY: Fluoride analyses were carried out on 42 different types and brands of milk obtained from supermarkets. The average fluoride content of dairy milk is 0.030 ppm, with a range of 0.007 to 0.068. Soy milk contains as much as 0.491 ppm fluoride. Infant daily fluoride intake as low as 0.04 mg/kg body weight can result in fluorosis of the permanent dentition. Therefore, in view of the very large variation in milk fluoride content, it is suggested that daily consumption of milk with high fluoride content could be a contributing factor to increased prevalence of dental fluorosis. In view of results of the present study, monitoring of fluoride content in dairy milk available from supermarkets may be necessary.
Long-term effects of the 11+ warm-up injury prevention programme on physical performance in adolescent male football players: a cluster-randomised controlled trial

ABSTRACT This study examined the long-term effects of the 11+ on physical performance in adolescent male football (soccer) players. Eighty-two 14- to 16-year-old male football players (11+ = 42 players, control = 40 players) participated. Teams were randomised to control (CON) and intervention (INT) groups. INT applied the 11+ injury prevention programme for 30 weeks at least twice a week as a warm-up. CON performed their standard warm-up. Motor performance tests were conducted 1 week prior and 1 week after the competition season. We used magnitude-based inferences and linear mixed-effects models to analyse performance test results. INT showed superior results compared to CON in the vertical jump height 7.5% (95%-CI 4.4%, 10.7%), the Bosco 15-s-jump test 7.2% (95%-CI 2.2%, 12.4%), and the Illinois agility test −2.6% (95%-CI −4.1%, −1.1%). Possibly beneficial effects in favour of INT were found in the 9.1 m sprint test −3.1% (95%-CI −6.1%, 0.1%). Possibly harmful effects (i.e. in favour of CON) were observed in the dribbling test 2.8% (95%-CI −0.8%, 6.4%). The 11+ warm-up programme can improve different performance measures in football players. Coaches might implement additional dribbling drills next to the 11+ to achieve improvements observed in dribbling ability when using a regular warm-up programme.
Post exercise high-fat feeding supresses p 70 S 6 K 1 activity in human skeletal 1 muscle 2 3

Centre for Exercise & Nutrition 26 Mary MacKillop Health Research Institute 27 Australian Catholic University 28 VIC 3065, Australia 29 30 Corresponding author: 31 Dr James Morton 32 Research Institute for Sport and Exercise Sciences 33 Liverpool John Moores University 34 Tom Reilly Building 35 Byrom St Campus 36 Liverpool 37 L3 3AF 38 United Kingdom 39 Email: J.P.Morton@ljmu.ac. uk 40 Tel: +44 151 904 6233 41
Social health insurance in Nepal: A health system departure toward the universal health coverage

The World Health Organization has identified universal health coverage (UHC) as a key approach in reducing equity gaps in a country, and the social health insurance (SHI) has been recommended as an important strategy toward it. This article aims to analyze the design, expected benefits and challenges of realizing the goals of UHC through the recently launched SHI in Nepal. On top of the earlier free health-care policy and several other vertical schemes, the SHI scheme was implemented in 2016 and has reached population coverage of 5% in the implemented districts in just within a year of implementation. However, to achieve UHC in Nepal, in addition to operationalizing the scheme, several other requirements must be dealt simultaneously such as efficient health-care delivery system, adequate human resources for health, a strong information system, improved transparency and accountability, and a balanced mix of the preventive, health promotion, curative, and rehabilitative services including actions to address the social determinants of health. The article notes that strong political commitment and persistent efforts are the key lessons learnt from countries achieving progressive UHC through SHI.
Effect of Stainless Steel-Containing Fabrics on Electromagnetic Shielding Effectiveness

In this paper, stainless steel is selected as the conductive filler to produce stainless steel hybrid yams to make woven fabrics. Using coaxial transmission equipment, the electro magnetic shielding effectiveness (EMSE) of these fabrics is measured. The experimental results show that a denser structure has a higher EMSE. The fabric made from the core yarns has a higher EMSE than that made from the cover yams and the plied yams. In addition, the EMSE of the fabric made from different genera of stainless steel has an optimum EMSE value at different measured frequencies. Analyses of the weave types reveal that the plain weave has a higher EMSE than other weave types.
Diet- and Genetically-induced Obesity Produces Alterations in the Microbiome, Inflammation and Wnt Pathway in the Intestine of Apc+/1638N Mice: Comparisons and Contrasts

Obesity is an established risk factor for colorectal cancer (CRC). Our previous study indicated that obesity increases activity of the pro-tumorigenic Wnt-signaling. Presently, we sought to further advance our understanding of the mechanisms by which obesity promotes CRC by examining associations between microbiome, inflammation and Wnt-signaling in Apc+/1638N mice whose obesity was induced by one of two modalities, diet- or genetically-induced obesity. Three groups were employed: Apc+/1638NLepr+/+ fed a low fat diet (10% fat), Apc+/1638NLepr+/+ fed a high fat diet (60% fat, diet-induced obesity), and Apc+/1638NLeprdb/db fed a low fat diet (genetically-induced obesity). All animals received diets for 16 weeks from 8 to 24 weeks of age. The abundance of 19 bowel cancer-associated bacterial taxa were examined by real-time PCR. The abundance of Turicibacter and Desulfovibrio decreased, but F. prausnitizii increased, in diet-induced obese mice (p < 0.05). In contrast, in genetically-induced obese mice, Bifidobacterium, A. muciniphila and E. rectale decreased, but Peptostrptococcus, and E. coli increased (p < 0.05). Both diet- and genetically-induced obesity altered the expression of genes involved in bacterial recognition (MyD88) and increased inflammation as indicated by elevated levels of cytokines (IFNγ and TNF-α for genetically-induced obesity, and IL-6 for diet-induced obesity). The elevated inflammation was associated with altered expression of genes that are integral components of the Wnt-signaling cascade in a fashion indicating its activation. These findings demonstrate that the composition of the small intestinal microbiome is affected differently in diet- and genetically-induced obesity, but both are associated with elevated intestinal inflammation and alterations of the Wnt pathway towards enhancing tumorigenesis.
Prophylaxis and Treatment of Alzheimer's Disease by Delivery of an Adeno-Associated Virus Encoding a Monoclonal Antibody Targeting the Amyloid Beta Protein

We previously reported on a monoclonal antibody (mAb) that targeted amyloid beta (Aß) protein. Repeated injection of that mAb reduced the accumulation of Aß protein in the brain of human Aß transgenic mice (Tg2576). In the present study, cDNA encoding the heavy and light chains of this mAb were subcloned into an adeno-associated virus type 1 (AAV) vector with a 2A/furin adapter. A single intramuscular injection of 3.0×1010 viral genome of these AAV vectors into C57BL/6 mice generated serum anti-Aß Ab levels up to 0.3 mg/ml. Anti-Aß Ab levels in excess of 0.1 mg/ml were maintained for up to 64 weeks. The effect of AAV administration on Aß levels in vivo was examined. A significant decrease in Aß levels in the brain of Tg2576 mice treated at 5 months (prophylactic) or 10 months (therapeutic) of age was observed. These results support the use of AAV vector encoding anti-Aß Ab for the prevention and treatment of Alzheimer's disease.
Causes of Differences in The Uptake of Cardiac Implantation Electronic Devices in Slovenia in Comparison To Other Countries

Abstract Introduction The purpose of this study is to analyse and present the causes of the differences in crude utilization rate in cardiac implantation electronic devices, specifically pacemakers and automatic implantable cardioverter-defibrillators, across 5 European countries, with a specific emphasis on Slovenia. Methods Based on the results of the analysis of the uptake of cardiac implantation electronic devices across countries studied in MedtecHTA project, the targeted interviews were conducted to explain the factors that impact the differences and explain data in Slovenia. Results The reasons for the differences in crude utilization rate across 5 European countries were multiple: the first group of differences refers to the coding system and linkages between coding and financing of health care. The second group of reasons can be qualitatively ascribed to the economic situation, financial situation in health care, and its impact on decision-making. The last reason is the non-existence of the golden rule for optimal crude utilisation rate. Conclusions It is evident that the differences in the uptake of cardiac implantation electronic devices among the countries are of organisational nature: they refer to the system of coding, the importance attached to correct coding practices, the link between coding and financing of health care as well as the availability of private clinics and private insurance. According to the interviews, the economic development of the country also impacts those differences, whereas the differences in clinical practice and guidelines are claimed not to play a role in the explanation of the differences.
Callous-unemotional traits drive reduced white-matter integrity in youths with conduct problems

Background. Callous-unemotional (CU) traits represent a significant risk factor for severe and persistent conduct problems in children and adolescents. Extensive neuroimaging research links CU traits to structural and functional abnormalities in the amygdala and ventromedial prefrontal cortex. In addition, adults with psychopathy (a disorder for which CU traits are a developmental precursor) exhibit reduced integrity in uncinate fasciculus, a white-matter (WM) tract that connects prefrontal and temporal regions. However, research in adolescents has not yet yielded similarly consistent findings. Method. We simultaneously modeled CU traits and externalizing behaviors as continuous traits, while controlling for age and IQ, in order to identify the unique relationship of each variable with WM microstructural integrity, assessed using diffusion tensor imaging. We used tract-based spatial statistics to evaluate fractional anisotropy, an index of WM integrity, in uncinate fasciculus and stria terminalis in 47 youths aged 10–17 years, of whom 26 exhibited conduct problems and varying levels of CU traits. Results. Whereas both CU traits and externalizing behaviors were negatively correlated with WM integrity in bilateral uncinate fasciculus and stria terminalis/fornix, simultaneously modeling both variables revealed that these effects were driven by CU traits; the severity of externalizing behavior was not related to WM integrity after controlling for CU traits. Conclusions. These results indicate that WM abnormalities similar to those observed in adult populations with psychopathy may emerge in late childhood or early adolescence, and may be critical to understanding the social and affective deficits observed in this population.
Sentiment Transfer using Seq2Seq Adversarial Autoencoders

Expressing in language is subjective. Everyone has a different style of reading and writing, apparently it all boil downs to the way their mind understands things (in a specific format). Language style transfer is a way to preserve the meaning of a text and change the way it is expressed. Progress in language style transfer is lagged behind other domains, such as computer vision, mainly because of the lack of parallel data, use cases, and reliable evaluation metrics. In response to the challenge of lacking parallel data, we explore learning style transfer from non-parallel data. We propose a model combining seq2seq, autoencoders, and adversarial loss to achieve this goal. The key idea behind the proposed models is to learn separate content representations and style representations using adversarial networks. Considering the problem of evaluating style transfer tasks, we frame the problem as sentiment transfer and evaluation using a sentiment classifier to calculate how many sentiments was the model able to transfer. We report our results on several kinds of models.
Atmospheric Chemistry and Physics

The total ozone field separated into meteorological regimes – Part II: Northern Hemisphere mid-latitude total ozone trends Abstract. Previous studies have presented clear evidence that the Northern Hemisphere total ozone field can be separated into distinct regimes (tropical, midlatitude, polar, and arctic) the boundaries of which are associated with the subtropical and polar upper troposphere fronts, and in the winter, the polar vortex. This paper presents a study of total ozone variability within these regimes, from 1979–2003, using data from the TOMS instruments. The change in ozone within each regime for the period January 1979–May 1991, a period of rapid total ozone change, was studied in detail. Previous studies had observed a zonal linear trend of −3.15% per decade for the latitude band 25 • –60 • N. When the ozone field is separated by regime, linear trends of −1.4%, 2.3%, and 3.0%, per decade for the tropical, midlatitude, and polar regimes, respectively, are observed. The changes in the relative areas of the regimes were also derived from the ozone data. The relative area of the polar regime decreased by about 20%; the tropical regime increased by about 10% over this period. No significant change was detected for the midlat-itude regime. From the trends in the relative area and total ozone it is deduced that 35% of the trend between 25 • and 60 • N, from January 1979–May 1991 is due to movement of the upper troposphere fronts. The changes in the relative areas can be associated with a change in the mean latitude of the subtropical and polar fronts within the latitude interval 25 • to 60 • N. Over the period from January 1979 to May 1991, both fronts moved northward by 1.1±0.2 degrees per decade. Over the entire period of the study, 1979–2003, the subtropical front moved northward at a rate of 1.1±0.1 degrees per decade, while the polar front moved by 0.5±0.1 degrees per decade.