Miracle-dz/UniFAR-FTUs huggingface dataset:
OF DIOXIN-LIKE COMPOUNDS IN SEDIMENT SAMPLES FROM OSAKA BAY , JAPAN

The combinatorial bio/chemical investigation of sediments (six surface samples and one core sample) from Osaka Bay, Japan was conducted to clarify the horizontal and vertical distribution profiles of persistent organic pollutants in the sediments. Concentrations of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs), polychlorinated biphenyls (PCBs), polybrominated dibenzo-p-dioxins and dibenzofurans (PBDD/Fs), and polybrominated diphenylethers (PBDEs) were determined by chemical analysis and compared to bioassay results using H4IIE-luc/Dioxin ResponsiveChemical Activated LUciferase eXpression (DR-CALUX). For surface sediments, World Health Organization-toxicity equivalent (WHO-TEQ) values ranged from 1.8 to 92 pg g dry weight and the bioassay-TEQ (CALUX-TEQ) values (3.7 – 140 pg g dry weight) yielded significant correlation with them (r = 0.96). On the other hand, correlation between both TEQs (for WHO-TEQ, 5.5 – 47 and for CALUX-TEQ, 27 – 76 pg g dry weight) for core samples was not so good (r = 0.46). Comparing the vertical profiles of CALUX-TEQ and WHO-TEQ, they were different in that WHO-TEQ reached the maximum in the 1957 core section, while CALUX-TEQ reached in the 1984 core section. CALUX-TEQ values were 1-5-fold more than WHO-TEQ values in all the surface and core samples. CALUX-TEQ values were calculated for PBDE and PBDD/F concentrations, employing their CALUX toxicity equivalent factors (CALUX-TEFs). The estimated CALUX-TEQ values obtained for the brominated compounds could explain for 11% on average (range 4.7 – 31%) of the experimentally obtained CALUX-TEQ values in the investigated surface sediments.
Multiple interactions between the splicing substrate and small nuclear ribonucleoproteins in spliceosomes

Protection experiments with antibodies against small nuclear ribonucleoproteins (snRNPs) have elucidated the location of and requirements for interactions between snRNPs and human beta-globin transcripts during splicing in vitro. U2 snRNP association with the intron branch site continues after branch formation, requires intact U2 RNA, and is affected by some alterations of the 3' splice site sequence. U2 snRNP binding to the branched intermediate and U1 snRNP protection of an extended 5' splice region are detected exclusively in spliceosome fractions, indicating that both snRNPs are spliceosome components. While each snRNP associates specifically with the pre-mRNA, they also appear to interact with each other. The recovery of fragments mapping upstream of the 5' splice site suggests how the excised exon is held in the spliceosome.
Learning Portfolio Analysis and Mining for SCORM Compliant Environment

With vigorous development of the Internet, e-learning system has become more and more popular. Sharable Content Object Reference Model (SCORM) 2004 provides the Sequencing and Navigation (SN) Specification to define the course sequencing behavior, control the sequencing, selecting and delivering of course, and organize the content into a hierarchical structure, namely Activity Tree. Therefore, how to provide customized course according to individual learning characteristics and capabilities, and how to create, represent and maintain the activity tree with appropriate associated sequencing definition for different learners become two important issues. However, it is almost impossible to design personalized learning activities trees for each learner manually. The information of learning behavior, called learning portfolio, can help teacher understand the reason why a learner got high or low grade. Thus, in this paper, we propose a Learning Portfolio Mining (LPM) Approach including four phases: 1. User Model Definition Phase: define the learner profile based upon existing articles and pedagogical theory. 2. Learning Pattern Extraction Phase: apply sequential pattern mining technique to extract the maximal frequent learning patterns from the learning sequence, transform original learning sequence into a bit vector, and then use distance based clustering approach to group learners with good learning performance into several clusters. 3. Decision Tree Construction Phase: use two third of the learner profiles with corresponding cluster labels as training data to create a decision tree, and the remainings are the testing data. 4. Activity Tree Generation Phase: use each created cluster including several learning patterns as sequencing rules to generate personalized activity tree with associated sequencing rules of SN. Finally, for evaluating our proposed approach of learning portfolio analysis, an experiment has been done and the results show that generated personalized activity trees with sequencing rules are workable and beneficial for learners.
A steerable and variable first-order differential microphone array

A new first-order differential microphone array with an infinitely steerable and variable beampattern is described. The microphone consists of 6 small pressure microphones flush-mounted on the surface of a 3/4" diameter rigid nylon sphere. The microphones are located on the surface at points where included octahedron vertices contact the spherical surface. By appropriately combining the three Cartesian orthogonal pairs with simple scalar weightings, a general first-order differential microphone beam (or beams) can be realized and directed to any angle in 4/spl pi/ steradian space. A working real-time version has been created and measured results from this microphone are shown. This microphone should be useful for surround sound recording/playback applications and to virtual reality audio applications.
Band-bending induced by charged defects and edges of atomically thin transition metal dichalcogenide films

We report scanning tunneling microscopy/spectroscopy (STM/STS) investigations of the band-bending in the vicinity of charged point defects and edges of monolayer MoSe2 and mono- and trilayer WSe2 films deposited on graphitized silicon carbide substrates. By tracing the spatial evolution of the structures of the STS spectra, we evaluate the magnitude and the extent of the band-bending to be equal to few hundreds milielectronvolts and several nanometres, respectively. With the aid of a simple electrostatic model, we show that the spatial variation of the Coulomb potential close to the film edges can be well reproduced by taking into account the metallic screening by graphene. Additionally, the analysis of our data for trilayer WSe2 provides reasonable estimations of its dielectric constant () and of the magnitude of the charge trapped at the defect site (Q = +e).
Review: Improving compliance with Helicobacter pylori eradication therapy: when and how?

Compliance with therapy is the single most important factor in Helicobacter pylori (H. pylori) eradication. Poorer levels of compliance with therapy are associated with significantly lower levels of eradication. Numerous factors can contribute to achieving good levels of compliance. These include the complexity and duration of treatment. It is also important that the physician is motivated to ensure eradication is confirmed and the patient is sufficiently informed to empower him or her to achieve high levels of compliance. Compliance is also contingent on medication regimes that are simple, safe, tolerable and efficacious. The opportunity to improve compliance exists at every point of contact between the patient and the medical services. Experts and opinion leaders in the field can play a role by ensuring that physicians are educated and motivated enough to encourage and support compliance with H. pylori eradication therapy. Both patients and physicians need to be aware of the importance of the bacterium in causing disease. The importance of the doctor—patient relationship is paramount. Pragmatic strategies that may be of assistance may come in the form of polypills, combined Blister Packs, adjuvant therapies and modified release compounds. Colleagues such as pharmacists and nurse specialists can also play an important role and should be actively engaged. Structured aftercare and follow up offers the best chance for ensuring compliance and subsequent eradication of the H. pylori pathogen.
Comparative Study of the Outcomes of Percutaneous Endoscopic Lumbar Discectomy and Microscopic Lumbar Discectomy Using the Tubular Retractor System Based on the VAS, ODI, and SF-36

Objective Percutaneous endoscopic lumbar discectomy (PELD) and microdiscectomy with the microscope endoscopic tubular retractor system(METRx-MD) are considered popular minimally invasive surgery (MIS) methods for the treatment of lumbar disc herniation. Many authors have also reported good clinical outcomes of these methods, but there are few comparative studies of them. This report compares the clinical outcomes of PELD and METRx-MD for lumbar disc herniation as MIS methods and discusses the efficacy of PELD. Methods Seventy-two patients who had undergone single-level unilateral discectomy using two different methods, PELD and METRx-MD, between 2009 and 2011 were given a follow-up examination prospectively. Thirty-seven of these patients underwent discectomy using PELD, and the remaining 35 patients underwent discectomy using METRx-MD. In addition to the general parameters, clinical outcomes were assessed as specific parameters using the Visual Analogue Scale (VAS) score, the Oswestry Disability Index (ODI), the Short-form 36 (SF-36), and the return-to-work time. Results Sixty-seven percent (25/37) of the patients in the PELD group and 74%(26/35) in the METRx-MD group were included in follow-up more than 6 months post-operatively. The mean improvements in the VAS scores for the back pain, leg pain, and ODI were 2.6, 4.8, and 30.1% for the PELD group and 2.8, 4.6, and 33.2% for the METRx-MD group, respectively. The SF-36 physical health component subscale score improved from 40.6 pre-operatively to 68.3 at the last follow-up for the PELD group post-operatively, and from 48.5 to 65.1 in the mental component subscale (METRx-MD group: from 34.4 to 66.5 and from 44.87 to 56.7). Complications occurred in 3/37 patients in the PELD group and in 2/35 patients in the METRx-MD group in the peri-operative period. The mean return-to-work times were 37.5 days in the PELD group and 42.5 days in the METRx-MD group. Conclusion The outcomes for the PELD group are comparable to those for the METRx-MD group. It can thus be concluded that PELD for lumbar disk herniations may be performed safely and effectively. Also, PELD can be considered one of the treatment modalities of lumbar disk herniation.
Comparison of Hay's Criteria with Nugent's Scoring System for Diagnosis of Bacterial Vaginosis

Although Nugent's criterion is considered as the gold standard for the diagnosis of bacterial vaginosis (BV), the method requires an experienced slide reader and considerable time and skill. In this study, we compared the method of Hay and Ison with Nugent's scoring criteria. Vaginal specimens were collected from a total of 213 women, presenting with or without the symptoms of vaginitis. Diagnosis of BV was done using Nugent' and Hay's method. Sensitivity, specificity, and predictive values for positive and negative test were calculated for Hay's method using Nugent's method as the gold standard. We diagnosed 70 cases (32.86%) of BV by Nugent's method and 87 (40.85%) cases by the Hay's method. Sensitivity, specificity, predictive value of positive result, predictive value of negative result, and Kappa value when evaluating Hay's criteria using Nugent's criteria as the gold standard were ≥97.2%, ≥88.1%, ≥80.4%, ≥97.1%, and ≥0.830, respectively, when Hay's grade II and/or Nugent's intermediate score were considered either as negative or positive or excluded. Using Nugent score for the intermediate group is the most difficult. Hay's method shows good agreement with the gold standard method of Nugent et al. and can be used as an alternative to Nugent's criteria in busy tertiary care hospitals.
Information-Preserving Spatial Filtering for Direction-of-Arrival Estimation

This work investigates the problem of directionof- arrival estimation with a large number of antennas. As in practice the number of antennas M is limited by power and hardware constraints, here the possibility to compress the receive signal, prior to the estimation task, to K < 2M real-valued outputs is discussed. Under a Bayesian perspective, we state the problem of finding a linear spatial filter (2M inputs, K outputs) which preserves the information about the directionof-arrival parameter in an optimum way. In order to attain the lowest possible mean squared error with the compressed data, the filter is designed such that the Bayesian Cramer-Rao bound is minimized. An iterative gradient-based filter solution is proposed and the potential estimation performance is investigated for different setups. Simulations of the maximum a posteriori (MAP) estimator show that the accuracy predicted by theory can be attained in practice at low computational cost.
Fetal/Placental Weight Ratio in Term Japanese Pregnancy: Its Difference Among Gender, Parity, and Infant Growth

Purpose: The “inappropriately heavy placenta” has been considered to be associated with various pregnancy disorders; however, data is scarce what factors affect it. To determine whether the following three affect it; (1) infant gender and mother's parity, (2) growth restriction, and (3) preeclampsia. Methods: We employed fetal/placental weight ratio (F/P). Subjects consisted of 53,650 infants and their placentas from women who vaginally delivered singleton live term infants. First, we examined whether F/P differs among the infant's gender or mother's parity. We classified the population into 4 categories according to gender and parity: male, nulliparous (n=7,431), male, multiparous (n=7,859), female, nulliparous (n=7,559), female, multiparous (n=7,800), and, compared F/P among the four groups. Next, we determined whether F/P differs in “small” or “large” for gestational age (SGA or LGA) infants, compared with appropriate for gestational age infants. Last, we determined whether preeclampsia (representative disorder of SGA) affects F/P. Results: (1) F/P significantly differed according to infant gender and parity: female and nulliparity had significantly smaller F/P. F/P was significantly smaller in (2) SGA infants, and (3) infants from preeclamptic mothers. Conclusion: We for the first time showed that in Japanese term vaginally-delivered singleton population, the following three had significantly smaller F/P than controls thus had “inappropriately heavy placenta”: (1) female gender and nulliparity, (2) SGA infants, and (3) infants from preeclamptic mothers. We recommend that these factors should be taken into account in evaluating placental weight. These data may also be useful for further clarifying the fetal-placental pathophysiology in these conditions.
Clarity and strength of implications for practice in medical journal articles: an exploratory analysis

Objective To examine how leading clinical journals report research findings, aiming to assess how they frame their implications for medical practice and to compare that literature's patterns with those of the management literature. Data Source Clinically relevant research articles from three leading clinical journals (N Engl J Med, JAMA, and Ann Intern Med). Methods Review of wording of a sequential sample from 2010, with categorisation, comparison among journals, and comparison with management literature. Results Clinical journals usually state that one approach did or did not differ from another approach (35 of 51 articles, 68.6%), but they recommended a specific course of action (‘therefore, x should be done’) in just 25.5%. One article gave instruction on how to implement the changes. Two-thirds of the reports called for further research. Half used tentative language. Management research articles nearly always specified who should use the information and drew from over 60 types of potential users, whereas the clinical literature named the audience in only 23.5% of clinicians. Conclusions Authors and editors of the clinical literature could test being more clear and direct in presenting implications of research findings for practice, including stating when the findings do not justify changes in practice.
InvisibleEye

Analysis of everyday human gaze behaviour has significant potential for ubiquitous computing, as evidenced by a large body of work in gaze-based human-computer interaction, attentive user interfaces, and eye-based user modelling. However, current mobile eye trackers are still obtrusive, which not only makes them uncomfortable to wear and socially unacceptable in daily life, but also prevents them from being widely adopted in the social and behavioural sciences. To address these challenges we present InvisibleEye, a novel approach for mobile eye tracking that uses millimetre-size RGB cameras that can be fully embedded into normal glasses frames. To compensate for the cameras’ low image resolution of only a few pixels, our approach uses multiple cameras to capture different views of the eye, as well as learning-based gaze estimation to directly regress from eye images to gaze directions. We prototypically implement our system and characterise its performance on three large-scale, increasingly realistic, and thus challenging datasets: 1) eye images synthesised using a recent computer graphics eye region model, 2) real eye images recorded of 17 participants under controlled lighting, and 3) eye images recorded of four participants over the course of four recording sessions in a mobile setting. We show that InvisibleEye achieves a top person-specific gaze estimation accuracy of 1.79° using four cameras with a resolution of only 5 × 5 pixels. Our evaluations not only demonstrate the feasibility of this novel approach but, more importantly, underline its significant potential for finally realising the vision of invisible mobile eye tracking and pervasive attentive user interfaces.
Nocturnal sleep mediates the relationship between morningness–eveningness preference and the sleep architecture of afternoon naps in university students

The present study investigated the parameters of nocturnal sleep that mediate the relationship between morningness–eveningness preference and the sleep architecture of naps in university students. This study had a cross-sectional, descriptive correlational design. The sleep architecture of 52 students invited to take an afternoon nap in the laboratory was recorded. The morningness–eveningness questionnaire (MEQ) was used to evaluate morningness–eveningness preference. An actigraph was used to collect students’ nighttime sleep data in the week preceding the study. Polysomnography was used to measure the sleep architecture of the participants’ naps. After adjustments for potential factors, although the MEQ did not directly correlate with the percentage of sleep stages in naps, the effects of the MEQ on the percentage of Stage 1 sleep, slow-wave sleep, and rapid eye movement sleep; sleep duration; and sleep efficiency of naps were mediated by the total sleep time in the preceding week. This preliminary study suggests that nap quality was affected by morningness–eveningness preference through the mediation of total nocturnal sleep time. Therefore, future studies should be carefully designed to consider nighttime sleep patterns when analyzing the effects of chronotypes on daytime sleep.
Artefacts of implant-supported single crowns - Impact of material composition on artefact volume on dental MRI.

PURPOSE MRI allows radiation-free imaging of the head and neck area. However, implant-supported prostheses may severely impair image quality due to artefacts. Therefore, identification of preferable material compositions for implants and supported prostheses with little impact on MR image quality is mandatory. MATERIALS AND METHODS Overall, one zirconia and four titanium dental implants were provided with different single crown materials: porcelain-fused-to-metal precious alloy (GP-T), porcelain-fused-to-metal non-precious alloy (CCT-T), porcelain-fused-to-zirconia (ZC-T) and monolithic zirconia (Z-T, Z-Z). Three-dimensional artefact volume was determined on a 3 Tesla MRI, applying two standard sequence types (SPACE and TSE). Two-way ANOVA and pair-wise post-hoc Turkey test were performed for comparison of artefact size. RESULTS Fewest MR artefacts were observed with zirconia implant combined with monolithic zirconia crown. A titanium implant combined with a single crown framework out of the non-precious alloys was unfavourable in terms of artefact volume. Smaller and comparable artefact volumes were noted for titanium implants with the remaining three crown materials (GP-T, ZC-T and Z-T). CONCLUSIONS Material composition of dental implants provided with single crowns has a profound impact on artefact volume. In comparison with crowns containing cobalt, chromium and tungsten, the MRI artefacts are reduced in precious alloy- and zirconia-based crowns. Further studies are needed to assess whether residual artefacts allow sufficient diagnostic imaging with these crowns. Conflict-of-interest statement: The authors have nothing to disclose.
Visual Servo Velocity and Pose Control of a Wheeled Inverted Pendulum through Partial-Feedback Linearization

Vision-based control of wheeled vehicles is a difficult problem due to nonholonomic constraints on velocities. This is further complicated in the control of vehicles with drift terms and dynamics containing fewer actuators than velocity terms. We explore one such system, the wheeled inverted pendulum, embodied by the Segway. We present two methods of eliminating the effects of nonactuated attitude motions and a novel controller based on partial feedback linearization. This novel controller outperforms a controller based on typical linearization about an equilibrium point
Experimental Evidence about the Persistence of High Prices in a Soft-Cap Auction for Electricity 1

I. Introduction The high prices for electricity in California during the summer of 2000 led to a substantial amount of regulatory and political intervention. Price caps were lowered and the Federal Energy Regulatory Commission (FERC) proposed that a new type of " soft-cap " auction be adopted to replace the uniform price auction. This auction combines a standard uniform price auction with a discriminative auction for offers higher than a specified soft-cap ($150/MWh). All offers to sell generating capacity below the soft-cap are submitted in a uniform price auction and paid a clearing price set to the last (highest) accepted offer. Any capacity offered above the soft-cap needed to meet the load is paid the actual offer in a discriminative price auction. With this structure, high offers above the soft-cap can not set the clearing price for all capacity sold. Nevertheless, high prices persisted during the winter of 2001. As a result, FERC abandoned the soft-cap auction in May, 2001. This paper presents results from four experiments using uniform and soft-cap auctions, with and without price-responsive load. The objective of this paper is to show that it is hard to mitigate high prices in a soft-cap auction when prices are driven above the soft-cap and to demonstrate how price-responsive load is a more effective strategy in uniform price auctions. Both industry professionals and students are used as participants who represent generators in a " smart " market, POWERWEB, which replicates the physical constraints of meeting loads on an electrical grid. The results of earlier experiments conducted with POWERWEB show that both a uniform price auction and a pure discriminative auction can produce average prices fifty percent above competitive levels (Mount et al. 2001). However, the prices for the uniform price auction are more volatile with many price spikes. This is because generators in a uniform price auction tend to submit low offers for large, lower cost units and speculate with or withhold their marginal, high cost units. The resulting offer curve takes the shape of a