Miracle-dz/UniFAR-FTUs huggingface dataset:
Representation and Timing in Theories of the Dopamine System

Although the responses of dopamine neurons in the primate midbrain are well characterized as carrying a temporal difference (TD) error signal for reward prediction, existing theories do not offer a credible account of how the brain keeps track of past sensory events that may be relevant to predicting future reward. Empirically, these shortcomings of previous theories are particularly evident in their account of experiments in which animals were exposed to variation in the timing of events. The original theories mispredicted the results of such experiments due to their use of a representational device called a tapped delay line. Here we propose that a richer understanding of history representation and a better account of these experiments can be given by considering TD algorithms for a formal setting that incorporates two features not originally considered in theories of the dopaminergic response: partial observability (a distinction between the animal's sensory experience and the true underlying state of the world) and semi-Markov dynamics (an explicit account of variation in the intervals between events). The new theory situates the dopaminergic system in a richer functional and anatomical context, since it assumes (in accord with recent computational theories of cortex) that problems of partial observability and stimulus history are solved in sensory cortex using statistical modeling and inference and that the TD system predicts reward using the results of this inference rather than raw sensory data. It also accounts for a range of experimental data, including the experiments involving programmed temporal variability and other previously unmodeled dopaminergic response phenomena, which we suggest are related to subjective noise in animals' interval timing. Finally, it offers new experimental predictions and a rich theoretical framework for designing future experiments.
Beta-adrenergic supersensitivity of the transplanted human heart is presynaptic in origin.

An increase in cardiac beta-adrenergic sensitivity or beta-receptor density or both has been described in several animal species after denervating the heart. The transplanted human heart is also denervated and, therefore, may exhibit supersensitivity to beta-adrenergic agonists and an increase in beta-adrenergic receptor density. In 16 patients examined 1-3 months after orthotopic cardiac transplantation, beta-adrenergic receptor density measured by [125I]iodocyanopindolol binding in endomyocardial biopsy specimens was not significantly different in transplant recipients compared with normal controls (transplant = 1,429 +/- 199, control = 1,728 +/- 263 fmol/g wet wt; p = NS). However, when normalized to Lowry protein, the [125I]iodocyanopindolol in beta-adrenergic receptor density in biopsy tissue from transplant recipients was significantly lower than in tissue from controls (transplant = 58.1 +/- 6.2, control = 93.5 +/- 13.4 fmol/g Lowry protein; p = 0.011). Atrial sinus node activity of the denervated donor heart and the innervated atrial cuff of the native recipient heart could be detected on the surface electrocardiogram in six patients. In these six patients, the heart rate response to graded infusions of epinephrine (taken up by the adrenergic nerve terminals) and isoproterenol (not taken up by the adrenergic nerve terminals) was measured. The epinephrine dose-response curve in transplanted donor atria was significantly to the left of the native recipient atrial dose-response curve (p less than 0.0001). The isoproterenol dose-response curves for native and transplanted atria were not different. We conclude that myocardial beta-adrenergic receptors are not increased in human orthotopic cardiac allografts and that there is no evidence for beta-receptor-mediated supersensitivity of postsynaptic origin. (ABSTRACT TRUNCATED AT 250 WORDS)
Sex differences in lifespan extension with acarbose and 17‐α estradiol: gonadal hormones underlie male‐specific improvements in glucose tolerance and mTORC2 signaling

Interventions that extend lifespan in mice can show substantial sexual dimorphism. Here, we show that male‐specific lifespan extension with two pharmacological treatments, acarbose (ACA) and 17‐α estradiol (17aE2), is associated, in males only, with increased insulin sensitivity and improved glucose tolerance. Females, which show either smaller (ACA) or no lifespan extension (17aE2), do not derive these metabolic benefits from drug treatment. We find that these male‐specific metabolic improvements are associated with enhanced hepatic mTORC2 signaling, increased Akt activity, and phosphorylation of FOXO1a – changes that might promote metabolic health and survival in males. By manipulating sex hormone levels through gonadectomy, we show that sex‐specific changes in these metabolic pathways are modulated, in opposite directions, by both male and female gonadal hormones: Castrated males show fewer metabolic responses to drug treatment than intact males, and only those that are also observed in intact females, while ovariectomized females show some responses similar to those seen in intact males. Our results demonstrate that sex‐specific metabolic benefits occur concordantly with sexual dimorphism in lifespan extension. These sex‐specific effects can be influenced by the presence of both male and female gonadal hormones, suggesting that gonadally derived hormones from both sexes may contribute to sexual dimorphism in responses to interventions that extend mouse lifespan.
A queueing model for random linear coding

In this work we consider coding over packets that randomly arrive to a source node for transmission to a single destination. We present a queueing model for a random linear coding scheme that adapts to the amount of traffic at the source node. If there is only one packet in the queue when the channel becomes free, then reliable transmission is carried out by retransmitting lost packets. If there are at least two packets in the queue, then random linear coding is carried out over the number of packets available in the queue when the channel becomes free. We provide a bulk-service queuing model and results on the delay of this random linear coding scheme, and show that its delay performance asymptotically approaches that of a retransmission scheme.
Expression of connexin 31 in the developing mouse cochlea

Connexin 31 (C×31) mutations cause an autosomal dominant form of high-frequency hearing loss. The immunohistochemical localization of C×31 in mouse cochlea was studied at different ages between 0 and 60 days after birth (DAB). C×31-like immunoreactivity was detected in fibrocytes of spiral ligament and spiral limbus at 12 DAB, gradually enhanced with the increase of age and reached the adult pattern on 60 DAB. Immunoreactivity decreased gradually from the basal to apical turn in all developmental stages. The mRNA of C×31 was also identified by RT-PCR. The distribution of C×31 and connexin 26 were obviously different in the developing mouse cochlea. The expression and distribution of C×31 in the development may explain the progressive hearing loss in human C×31 mutations.
Decreasing Cx36 Gap Junction Coupling Compensates for Overactive KATP Channels to Restore Insulin Secretion and Prevent Hyperglycemia in a Mouse Model of Neonatal Diabetes

Mutations to the ATP-sensitive K+ channel (KATP channel) that reduce the sensitivity of ATP inhibition cause neonatal diabetes mellitus via suppression of β-cell glucose-stimulated free calcium activity ([Ca2+]i) and insulin secretion. Connexin-36 (Cx36) gap junctions also regulate islet electrical activity; upon knockout of Cx36, β-cells show [Ca2+]i elevations at basal glucose. We hypothesized that in the presence of overactive ATP-insensitive KATP channels, a reduction in Cx36 would allow elevations in glucose-stimulated [Ca2+]i and insulin secretion to improve glucose homeostasis. To test this, we introduced a genetic knockout of Cx36 into mice that express ATP-insensitive KATP channels and measured glucose homeostasis and islet metabolic, electrical, and insulin secretion responses. In the normal presence of Cx36, after expression of ATP-insensitive KATP channels, blood glucose levels rapidly rose to >500 mg/dL. Islets from these mice showed reduced glucose-stimulated [Ca2+]i and no insulin secretion. In mice lacking Cx36 after expression of ATP-insensitive KATP channels, normal glucose levels were maintained. Islets from these mice had near-normal glucose-stimulated [Ca2+]i and insulin secretion. We therefore demonstrate a novel mechanism by which islet function can be recovered in a monogenic model of diabetes. A reduction of gap junction coupling allows sufficient glucose-stimulated [Ca2+]i and insulin secretion to prevent the emergence of diabetes.
Gender Differences in the Assessment and Manifestation of Psychopathy: Results From a Multicenter Study in Forensic Psychiatric Patients

abstract Gender differences were explored in PCL-R codings and the manifestation of psychopathy in 197 female and 197 male patients admitted between 1984 and 2013 to one of four Dutch forensic psychiatric hospitals. Four groups were compared with respect to criminological characteristics, historical violence risk factors and psychiatric characteristics including incidents during treatment. The lowered PCL-R cut-off score of 23 as applied in the Female Additional Manual (FAM; de Vogel, de Vries Robbé, van Kalmthout, & Place, 2012) was used to define women with psychopathy. The four groups were: (1) women without psychopathy (PCL-R < 23), (2) women with psychopathy (PCL-R ≥ 23), (3) men without psychopathy (PCL-R < 30), and (4) men with psychopathy (PCL-R ≥ 30). Overall, it was found that women and men with psychopathy show multiple similarities in their personal and criminal histories, but there were also several gender differences. Women with psychopathy compared to men with psychopathy committed more fraud, offended more often out of relational frustration, were more often diagnosed with the Borderline Personality Disorder, and showed less physical violence, but more manipulative and self-destructive behavior during treatment. Overall, women obtained lower scores on the PCL-R than men. Predictive validity of the PCL-R for physical violence during treatment was good for men and moderate for women. When verbal violence was included in the definition of violence, the predictive validity of the PCL-R was good for both the female and male sample. Implications of this study for forensic practice are discussed and several directions for future research are provided.
Cognate status, syllable position and word length on bilingual Tip-Of-the-Tongue states induction and resolution

This study explores the role of cognate status, syllable position, and word length in Tip-of-the-Tongue (TOT) states induction and resolution for European Portuguese (EP; L1) – English (L2) bilinguals (and EP monolinguals as control). TOTs were induced using a picture naming task in L1 and L2 followed by a lexical decision task. Here, the first or the last syllable of the target word (or none for control) was embedded in pseudowords (syllabic pseudohomophones) in order to test its effect in TOT resolution. Bilinguals presented more TOTs in L2 than in L1, especially for noncognate words. Longer words showed more TOTs than shorter words, though only in L1. TOT resolution was higher for cognates in L2 and higher when primed by the first than by the last syllable. Finally, longer cognates showed more TOT resolution than shorter cognates, irrespective of the language. Results are discussed in light of TOT's main hypothesis.
A Prospective Multicenter Study of the Efficacy and Tolerability of Cryopreserved Allogenic Human Keratinocytes to Treat Venous Leg Ulcers

Allogeneic human keratinocyte cultures have been used to treat burn wounds, donor sites, and chronic skin ulcers with some success. Cryopreservation of these cultures allows for the production of large standardized batches that are readily available for use. The aim of the study presented in this report was to study effects of cryopreserved cultured allogenic human keratinocytes (Cryo Ceal) on chronic lower extremity wounds. Parameters were measured to study efficacy, tolerability, pain associated with chronic wounds, and quality of life of patients. Twenty-seven patients with hard-to-heal venous leg ulcers received a maximum of 9 applications of Cryo Ceal in a prospective, uncontrolled multicenter study lasting 48 weeks. Eleven out of 27 patients (41%; 95% CI: 22%-61%) had complete wound closure within 24 weeks (1 week). The time required for complete wound closure in these 11 patients ranged from 4.1 to 24.9weeks. Only 1 patient had recurrence of the ulcer at 48 weeks. Local (wound) pain scores decreased from a mean of 2.5 at baseline to 0.9 at week 24. Fifty percent of the patients attained a pain score of 0 after 12 weeks and remained stable at this score until the end of the study. Overall, the patient quality of life was better at week 24, compared to baseline values. The treatment was well tolerated, and wound infection was the most frequently occurring adverse event.
Effects of Relative Status and Relationship on Negotiation Expectations and Joint Outcome

Most organizational behavior research in general, and negotiation research in particular,have paid little attention to the role of relative status between social exchange parties. In this paper, we note that while past research and theory on status tends to assume a competitive relationship between parties of different status and a fixed-sum pool of status resources, such assumptions do not apply to exchange between parties of different status in cooperative relationships. Accordingly, we hypothesized an interactive effect between status differential (unequal vs. equal) and relationship (cooperative vs. competitive). The negative impact of status differential on interactions and outcomes between exchange parties of different status would be reduced in cooperative relationships, but not so in competitive relationships. Theoretical implications to research in negotiation, status, and social exchange are discussed.
“FAT PAD” AND “LITTLE FINGER PULP” SIGNS ARE GOOD INDICATORS OF PROPER RELEASE OF CARPAL TUNNEL

OBJECTIVEThe release of the transverse carpal ligament (TCL) for relief of carpal tunnel syndrome has been a standard operative procedure since the early 1950s. Although complications are not common after the open surgical technique, a small but significant group of patients will have similar symptoms after surgery or will experience new symptoms in the postoperative period. Incomplete section of the TCL is the major cause of these complications. The authors have described two signs that confirm a complete release of the TCL, called the “fat pad” and “little finger pulp” signs. METHODSBetween 2000 and 2003, we treated 643 hands in 611 patients (45 men and 566 women; age range, 32–76 yr; mean age, 58.2 yr). All patients were examined 6 months after the procedure, with special attention given to the persistence or recurrence of symptoms. The presence of palmar scar pain, residual numbness, patient satisfaction, and time to return to work were also evaluated. A longitudinal incision (2 cm) at the base of the palm was used to release the TCL. A good indicator that the distal TCL has been released is the visualization of a fatty tissue (“fat pad” sign). This fatty tissue is always present underneath the most distal fibers of the TCL, covering the sensory digital branches of the median nerve. To confirm the complete release of the proximal fibers of the TCL, we should be able to introduce the little finger pulp in a proximal direction underneath the distal flexion crease of the wrist (“little finger pulp” sign). When both signs are confirmed, we can be certain that the TCL is completely released. RESULTSNight pain disappeared immediately after surgery in all patients except three. There were seven complications (1%) not related to the palmar scar and 10 complications (1.5%) related to it. However, all of these complications disappeared an average of 3 months postoperatively. Patient satisfaction was 100%, and the mean time to return to work and full activity was 22 days (range, 14–36 d). CONCLUSIONTwo surgical observations that are reliable to confirm a complete release of the TCL were described. The first, called the “fat pad” sign, is useful to determine whether or not the distal end of the TCL has been adequately released, whereas the “little finger pulp” sign indicates whether or not the proximal end of the TCL has been fully divided.
Improved algorithms for hypergraph bipartitioning

Multilevel Fiduccia-Mattheyses (MLFM) hypergraph partitioning is a fundamental optimization in VLSI CAD physical design. The leading implementation, hMetis, has since 1997 proved itself substantially superior in both runtime and solution quality to even very recent work. In this work, we present two sets of results: (i) new techniques for flat FM-based hypergraph partitioning (which is the core of multilevel implementations), and (ii) a new multilevel implementation that offers leading-edge performance. Our new techniques for flat partitioning confirm the conjecture that specialized partitioning heuristics may be able to actively exploit fixed nodes in partitioning instances arising in the driving top-down placement context. Our FM variant is competitive with traditional FM on instances without terminals and considerably superior on instances with fixed nodes (i.e., arising during top-down placement). Our multilevel FM variant avoids several complex heuristics and non-trivial tunings that often lead to complex implementations; it achieves trade-offs between solution quality and run time that are comparable or better than those achieved by hMetis-1.5. 3. We attempt to provide algorithm descriptions that are as detailed and unambiguous as possible, to allow replicability and speed improvements in future research.
Child Malnutrition in Pakistan: Trends and Determinants

The major objective of this paper to examine the determinants of child malnutrition, based on the Pakistan Panel Household Survey (PPHS-2010). The study has focused on individual (child), household and community variables to understand differentials in child malnutrition. Child illness, health status of their mothers and poverty status of households are the key factors utilized in this study to understand the malnutrition phenomenon. [PIDE Working paper]. URL:[http://www.pide. org.pk/pdf/Working%20Paper/Child%20Malnutrition%20.pdf].
Cross‐sectional associations of impaired glucose metabolism measures with bleeding on probing and periodontitis

AIM This study assessed the associations of pre-diabetes and insulin resistance with bleeding on probing (BOP) and periodontitis among adults. MATERIALS AND METHODS We included 1191 Hispanic adults aged 40-65 years, free of diabetes, enrolled in San Juan Overweight Adults Longitudinal Study. Pre-diabetes was defined as impaired fasting glucose (IFG), impaired glucose tolerance (IGT), or impaired glycated haemoglobin. Impaired one-hour plasma glucose (1hPG) was defined as levels >155 mg/dl. Insulin resistance was defined using the study population-specific 75th percentile (HOMA-IR ≥ 3.13). High BOP was defined as percentage of teeth with bleeding ≥30%. Periodontitis was defined according to the CDC/AAP definition. RESULTS After multivariable adjustment for age, gender, education, smoking status, alcohol consumption, physical activity, obesity, HDL-C, and plaque index, pre-diabetes with and without 1hPG, IFG, impaired 1hPG, IGT, and HOMA-IR were significantly associated with high BOP; pre-diabetes, IFG, and impaired 1hPG were significantly associated with severe periodontitis. Most of these associations remained significant when the analyses were restricted to non-smokers. CONCLUSIONS This study suggests associations between pre-diabetes and insulin resistance with BOP and periodontitis. Given the high prevalence of impaired glucose metabolism and periodontitis, the assessment of the temporal sequence of these associations is of utmost importance.
Parents talking to youth about sex and AIDS.

The consensual finding in health communication for behaviour change is that information doesnt work by itself. This paper has reflected on a small slice – booklets directed at parents - of sprawling splattering segmenting campaigns incorporating various mediums and tactics. What works? Research suggests a gathering progression of three phases: accurate information; practical skills as forms of negotiation and experiential opportunities or role-plays to try these tactics out; and finally community-based participatory approaches that tackle norms dominant attitudes and behavourial practices that embed youth and their families. (excerpt)
Spanish migrants to European Union countries: predictors of psychological adjustment / Españoles que emigran a países de la Unión Europea: predictores de su ajuste psicológico

Abstract In recent years, the migration of Spanish people to other countries in Europe has increased; however, there are hardly any studies on this phenomenon. The aim of this study is to identify the predictive sociodemographic and psychosocial factors of psychological adjustment (life satisfaction and absence of internalizing symptoms) of emigrants and to determine the indirect effects of these factors through perceived stress. This study also seeks to examine whether the psychological adjustment of Spanish emigrants was similar to Spanish non-emigrants. The sample was made up of a group of Spanish emigrants to Germany and England (n = 858) and an equivalent control group of Spanish non-emigrants (n = 328). The results show that fulfilment of expectations, emotional support and job quality are the best predictors of perceived stress and psychological adjustment. These factors are confirmed to have indirect effects on psychological adjustment through perceived stress. Finally, the mental health of emigrants and non-emigrants was similar, and the implications of these findings are discussed.
ERCC1 and ERCC2 expression in malignant tissues from ovarian cancer patients.

BACKGROUND ERCC1 and ERCC2 are human DNA repair genes that are associated with in vitro resistance to selected DNA-damaging agents. PURPOSE Fresh tumor tissues from 26 patients with ovarian cancer were analyzed for the RNA levels of expression of these genes to determine possible clinical relevance. METHODS Tumor tissues were harvested from patients immediately before they entered a cisplatin- or carboplatin-based treatment protocol. Clinical response was assessed by standard criteria. Gene expression level was assessed by slot blot analysis, using beta-actin as a control. Relative expression levels were determined by comparing each tumor sample with a Chinese hamster ovary cell line that had a stable transfection of the human ERCC1 gene. RESULTS Patients who were clinically resistant to platinum-based therapy had a 2.6-fold higher expression level of ERCC1 in their tumor tissue than did patients who responded to that therapy (P = .015). Results obtained by slot blot analysis were qualitatively confirmed by polymerase chain reaction analysis. Relative levels of expression of ERCC2 did not differ significantly between responders and nonresponders. CONCLUSION We conclude that ERCC1 expression levels in human tumor tissue may have a role in clinical resistance to platinum compounds. These data appear to be consistent with the assertion that ERCC1 serves as an excision nuclease, whereas ERCC2 serves as a helicase.