Miracle-dz/UniFAR-FTUs huggingface dataset:
Antioxidant Intake and Antitumor Therapy: Toward Nutritional Recommendations for Optimal Results

The role of the induction of oxidative stress as the mechanism of action of many antitumor drugs is acquiring an increasing interest. In such cases, the antitumor therapy success may be conditioned by the antioxidants present in our own body, which can be synthesized de novo (endogenous) or incorporated through the diet and nutritional supplements (exogenous). In this paper, we have reviewed different aspects of antioxidants, including their classification, natural sources, importance in diet, consumption of nutritional supplements, and the impact of antioxidants on health. Moreover, we have focused especially on the study of the interaction between antioxidants and antitumor therapy, considering both radiotherapy and chemotherapy. In this regard, we found that the convenience of administration of antioxidants during cancer treatment still remains a very controversial issue. In general terms, antioxidants could promote or suppress the effectiveness of antitumor treatment and even protect healthy tissues against damage induced by oxidative stress. The effects may depend on many factors discussed in the paper. These factors should be taken into consideration in order to achieve precise nutritional recommendations for patients. The evidence at the moment suggests that the supplementation or restriction of exogenous antioxidants during cancer treatment, as appropriate, could contribute to improving its efficiency.
Trajectory based event tactics analysis in broadcast sports video

Most of existing approaches on event detection in sports video are general audience oriented. The extracted events are then presented to the audience without further analysis. However, professionals, such as soccer coaches, are more interested in the tactics used in the events. In this paper, we present a novel approach to extract tactic information from the goal event in broadcast soccer video and present the goal event in a tactic mode to the coaches and sports professionals. We first extract goal events with far-view shots based on analysis and alignment of web-casting text and broadcast video. For a detected goal event, we employ a multi-object detection and tracking algorithm to obtain the players and ball trajectories in the shot. Compared with existing work, we proposed an effective tactic representation called aggregate trajectory which is constructed based on multiple trajectories using a novel analysis of temporal-spatial interaction among the players and the ball. The interactive relationship with play region information and hypothesis testing for trajectory temporal-spatial distribution are exploited to analyze the tactic patterns in a hierarchical coarse-to-fine framework. The experimental results on the data of FIFA World Cup 2006 are promising and demonstrate our approach is effective.
Pex13 Inactivation in the Mouse Disrupts Peroxisome Biogenesis and Leads to a Zellweger Syndrome Phenotype

ABSTRACT Zellweger syndrome is the archetypical peroxisome biogenesis disorder and is characterized by defective import of proteins into the peroxisome, leading to peroxisomal metabolic dysfunction and widespread tissue pathology. In humans, mutations in the PEX13 gene, which encodes a peroxisomal membrane protein necessary for peroxisomal protein import, can lead to a Zellweger phenotype. To develop mouse models for this disorder, we have generated a targeted mouse with a loxP-modified Pex13 gene to enable conditional Cre recombinase-mediated inactivation of Pex13. In the studies reported here, we crossed these mice with transgenic mice that express Cre recombinase in all cells to generate progeny with ubiquitous disruption of Pex13. The mutant pups exhibited many of the clinical features of Zellweger syndrome patients, including intrauterine growth retardation, severe hypotonia, failure to feed, and neonatal death. These animals lacked morphologically intact peroxisomes and showed deficient import of matrix proteins containing either type 1 or type 2 targeting signals. Biochemical analyses of tissue and cultured skin fibroblasts from these animals indicated severe impairment of peroxisomal fatty acid oxidation and plasmalogen synthesis. The brains of these animals showed disordered lamination in the cerebral cortex, consistent with a neuronal migration defect. Thus, Pex13−/− mice reproduce many of the features of Zellweger syndrome and PEX13 deficiency in humans.
Multiple Access Wiretap channels with strong secrecy

The problem of secure communication over Multiple-Access Wiretap channel (MAC-WTC) under strong secrecy criterion is investigated. A new technique based on channel output statistics approximation is developed for establishing the strong security over multi-user channels. In particular, this technique shows that how simple wiretap coding results in secure communication under strong secrecy criterion instead of weak secrecy criterion. As a side result of the paper, two results on the output statistics of MAC are provided. Such results can be used to approximate the mutual information between input and output of MAC with respect to a given codebook of arbitrary rate.
Herbal Extracts Combination (WNK) Prevents Decline in Spatial Learning and Memory in APP/PS1 Mice through Improvement of Hippocampal Aβ Plaque Formation, Histopathology, and Ultrastructure

To investigate the cognitive enhancement effect of WNK, an extracts combination of P. ginseng, G. biloba, and C. sativus L. and possible mechanisms, 5-month-old APP/PS1 transgenic mice were used in this study. After 3 months of administration, all mice received Morris water maze (MWM) training and a probe test. Mouse brain sections were detected by immunohistochemistry, HE staining, and transmission electron microscopy. MWM results showed significant difference between transgenic mice and nontransgenic littermates (P < 0.05, P < 0.01). WNK-treated mice exhibited enhanced maze performance over the training progression, especially better spatial memory retention in probe test compared to transgenic mice (P < 0.05, P < 0.01) and better spatial learning and memory at the fourth day of MWM test compared to EGB761- (G. biloba extract-) treated ones (P < 0.05). Hippocampal Aβ plaque burden significantly differed between APP/PS1 and littermate mice (P < 0.001), while decreased Aβ plaque appeared in WNK- or EGB761-treated transgenic brains (P < 0.05). Neurodegenerative changes were evident from light microscopic and ultrastructural observations in transgenic brains, which were improved by WNK or EGB761 treatment. These data indicate WNK can reduce the decline in spatial cognition, which might be due to its effects on reducing Aβ plaque formation and ameliorating histopathology and ultrastructure in hippocampus of APP/PS1 mouse brain.
Semantics-based Refinement of Mandatory Behavior of Sequence Diagrams

Sequence diagrams are a widely used design notation for describing software behavior. Many reusable software artifacts such as design patterns and design aspects make use of sequence diagrams to describe interaction behavior. When a pattern or an aspect is reused in an application, it is important to ensure that the sequence diagrams for the application correctly refines the corresponding sequence diagrams for the pattern or aspect. However, reasoning about refinement of sequence diagrams has not been addressed adequately. In this paper, we focus on refinement of required behavior specified by a UML sequence diagram. A novel trace semantics is given that captures precisely required behavior specified by a sequence diagram and a refinement relation between sequence diagrams is formalized based on the semantics. Properties of the trace semantics and the refinement relation are studied.
Collaboration: Closing the Effective Teaching Gap.

Over the last decade, policy and business leaders have come to know what parents have always known: teachers are the largest school-based factor in student achievement.1 Yet not all schools have equal access to the most effective teachers. High-needs schools that serve large proportions of economically disadvantaged and minority students are more likely to having difficulty recruiting and retaining teachers, particularly in high-demand subjects like math and special education.2 As a result, they are much more likely to fill those openings with out-of-field, inexperienced, and less well-prepared teachers.3 Simply put, the student achievement gap is largely explained by an effective teaching gap.
The effects of age and type of carrying task on lower extremity kinematics

The purpose of this study was to determine the effects of age, load amount and load symmetry on lower extremity kinematics during carrying tasks. Forty-two participants in four age groups (8–10 years, 12–14 years, 15–17 years and adults) carried loads of 0%, 10% and 20% body weight (BW) in large or small buckets unilaterally and bilaterally. Reflective markers were tracked to determine total joint range of motion and maximum joint angles during the stance phase of walking. Maximum hip extension, hip adduction and hip internal rotation angles were significantly greater for each of the child/adolescent age groups as compared with adults. In addition, maximum hip internal rotation angles significantly increased when carrying a 20% BW load. The observation that the 8–10-year-old age group carried the lightest absolute loads and still displayed the highest maximum hip internal rotation angles suggests a particular necessity in setting carrying guidelines for the youngest children. Statement of Relevance: Bucket-carrying tasks were analysed as a function of age group, load amount and load symmetry. Hip joint rotations significantly increased when carrying 20% BW loads and in children as compared to adults, which suggests a particular necessity in setting carrying guidelines for the youngest age group (8–10 year olds).
Foreign Aid, Poor Data, and the Fragility of Macroeconomic Inference

The link between foreign aid and economic growth remains a controversial issue in the literature, and a large share of the disagreement could be explained by differences in the data employed. Using GDP data from three different versions of the Penn World Table and the World Development Indicators, I investigate the robustness of Juselius, Moller and Tarp (2014)'s (JMT) conclusions about long-run aid effectiveness. The analysis is carried out in two stages. First, I apply the same models as developed by JMT to the new datasets. Second, I re-specify the Cointegrated VAR models using the same criteria as JMT, but limit the analysis to the four most and least consistent countries respectively. The first exercise shows that results change in a significant manner in approximately 10 of the 36 countries examined. The second exercise shows that the if the models are re-specified for each country and dataset individually as a function of the data, this leads to more qualitative changes in the conclusions.
ReviewTestosterone and Erectile Dysfunction

Aging is associated with a decline in several important health factors in men, including libido. Serum testosterone concentrations also decrease with age, and many age-related clinical features are closely associated with androgen deficiency, including erectile function (ED). Approximately 70% of ED is of organic origin, with the major risk factors being diabetes mellitus, hypercholesterolemia, smoking and chronic medical illnesses. These are also established risk factors for atherosclerosis, which is the predominant predisposing factor of vasculogenic ED. The introduction of phosphodiasterase-5 (PDE-5) inhibitors for the treatment of ED made a significant impact both in terms of clinical efficacy, and increasing the awareness of the condition. In spite of this, some patients fail to respond to PDE-5 inhibitors alone. Both animal and clinical studies indicate that testosterone therapy improves both erectile function and the response to PDE-5 inhibitors in patients with ED and hypogonadism. Indeed, interventional studies demonstrate that testosterone replacement therapy improves erectile function in hypogonadal men who have previously failed to respond to PDE-5 inhibitors alone. Furthermore, it has been demonstrated that the full therapeutic potential of PDE5 inhibitors will only become manifest in a eugonadal state. Recent studies have demonstrated a close relationship between testosterone and ED and suggest that testosterone therapy may be a valuable option for an increasing number of affected men. European guidelines recommend that all men presenting with ED should have their testosterone concentrations measured.
Relative Age Effects in Mathematics and Reading: Investigating the Generalizability across Students, Time and Classes

A child's age in comparison to the age of her or his classmates (relative age) has been found to be an influential factor on academic achievement, particularly but not exclusively at the beginning of formal schooling. However, few studies have focused on the generalizability of relative age effects. To close this gap, the present study analyzes the generalizability across students with and without immigrant backgrounds, across three student cohorts that entered school under a changing law of school enrollment, and across classes. To this end, we capitalized on representative large-scale data sets from three student cohorts attending public schools in Berlin, the capital of Germany. We analyzed the data using a multilevel framework. Our results for the overall student sample indicate relative age effects for reading and mathematics in favor of the relatively older students in Grade 2 that become somewhat smaller in size in Grade 3. By Grade 8, relative age effects had vanished in reading and had even reversed in favor of the relatively young in mathematics. Furthermore, relative age effects were not found to be systematically different among students with and without immigrant backgrounds, student cohorts, or across classes. Taken together, these results empirically underscore the broad generalizability of the findings as found for the overall student population and replicate the pattern of findings on relative effects as identified by the majority of previous studies.
Causal inference of gene regulation with subnetwork assembly from genetical genomics data

Deciphering the causal networks of gene interactions is critical for identifying disease pathways and disease-causing genes. We introduce a method to reconstruct causal networks based on exploring phenotype-specific modules in the human interactome and including the expression quantitative trait loci (eQTLs) that underlie the joint expression variation of each module. Closely associated eQTLs help anchor the orientation of the network. To overcome the inherent computational complexity of causal network reconstruction, we first deduce the local causality of individual subnetworks using the selected eQTLs and module transcripts. These subnetworks are then integrated to infer a global causal network using a random-field ranking method, which was motivated by animal sociology. We demonstrate how effectively the inferred causality restores the regulatory structure of the networks that mediate lymph node metastasis in oral cancer. Network rewiring clearly characterizes the dynamic regulatory systems of distinct disease states. This study is the first to associate an RXRB-causal network with increased risks of nodal metastasis, tumor relapse, distant metastases and poor survival for oral cancer. Thus, identifying crucial upstream drivers of a signal cascade can facilitate the discovery of potential biomarkers and effective therapeutic targets.
Application of USLE Model & GIS in Estimation of Soil Erosion for Tandula Reservoir

Assessment of soil erosion is expensive and intensively long exercise. A number of parametric models have been developed to forecast soil erosion at drainage basins, yet Universal Soil Loss Equation, popularly known as USLE model is most widely used empirical formula for estimating annual soil loss from agricultural basins. With the advance of Remote Sensing technique it becomes possible to measure hydrologic parameters on spatial scales while Geographic Information System integrates the spatial analytical functionality for spatially distributed data. In the present paper the application of USLE model and GIS, for soil loss estimation has been presented for the Tandula reservoir catchment area on Tanudula River at Balod Tehsil of Durg district of Chhattisgarh State, India. The result obtained from USLE model has been compared with existing model , Nayak and Khosla;s method, it is observed that USLE with GIS give better result as compared to other two methods. Keywords—GIS, ILWIS, Map, Soil Erosion, USLE.
Selective Corticospinal Tract Injury in the Rat Induces Primary Afferent Fiber Sprouting in the Spinal Cord and Hyperreflexia

The corticospinal tract (CST) has dense contralateral and sparse ipsilateral spinal cord projections that converge with proprioceptive afferents on common spinal targets. Previous studies in adult rats indicate that the loss of dense contralateral spinal CST connections after unilateral pyramidal tract section (PTx), which models CST loss after stroke or spinal cord injury, leads to outgrowth from the spared side into the affected, ipsilateral, spinal cord. The reaction of proprioceptive afferents after this CST injury, however, is not known. Knowledge of proprioceptive afferent responses after loss of the CST could inform mechanisms of maladaptive plasticity in spinal sensorimotor circuits after injury. Here, we hypothesize that the loss of the contralateral CST results in a reactive increase in muscle afferents from the impaired limb and enhancement of their physiological actions within the cervical spinal cord. We found that 10 d after PTx, proprioceptive afferents sprout into cervical gray matter regions denervated by the loss of CST terminations. Furthermore, VGlut1-positive boutons, indicative of group 1A afferent terminals, increased on motoneurons. PTx also produced an increase in microglial density within the gray matter regions where CST terminations were lost. These anatomical changes were paralleled by reduction in frequency-dependent depression of the H-reflex, suggesting hyperreflexia. Our data demonstrate for the first time that selective CST injury induces maladaptive afferent fiber plasticity remote from the lesion. Our findings suggest a novel structural reaction of proprioceptive afferents to the loss of CST terminations and provide insight into mechanisms underlying spasticity.
Visuospatial deficits of dyslexic children

Summary Background The visuospatial deficit is recognized as typical for dyslexia only in some definitions. However problems with visuospatial orientation may manifest themselves as difficulties with letter identification or the memorizing and recalling of sign sequences, something frequently experienced by dyslexics. Material/Methods The experimental group consisted of 62 children with developmental dyslexia. The control group consisted of 67 pupils with no diagnosed deficits, matched to the clinical group in terms of age. We used the Clock Drawing Test (CDT), the Spatial Span subtest from the Wechsler Memory Scale – third edition (WMS – III), the Rey-Osterrieth Complex Figure Test in order to analyze visuospatial functioning. Results The results show that dyslexics experienced problems with visuospatial functioning, however only while performing difficult tasks. Significant group differences were found for the Clock Drawing Test, Spatial Span – Backward and the precision of figure coping in the Rey-Osterrieth Test. In addition, the results of dyslexic boys were lower than those obtained by all other groups. Conclusions Our findings provide support for the hypothesis concerning visual deficit as characteristic for dyslexia.
A Novel Feature Extraction Method with Feature Selection to Identify Golgi-Resident Protein Types from Imbalanced Data

The Golgi Apparatus (GA) is a major collection and dispatch station for numerous proteins destined for secretion, plasma membranes and lysosomes. The dysfunction of GA proteins can result in neurodegenerative diseases. Therefore, accurate identification of protein subGolgi localizations may assist in drug development and understanding the mechanisms of the GA involved in various cellular processes. In this paper, a new computational method is proposed for identifying cis-Golgi proteins from trans-Golgi proteins. Based on the concept of Common Spatial Patterns (CSP), a novel feature extraction technique is developed to extract evolutionary information from protein sequences. To deal with the imbalanced benchmark dataset, the Synthetic Minority Over-sampling Technique (SMOTE) is adopted. A feature selection method called Random Forest-Recursive Feature Elimination (RF-RFE) is employed to search the optimal features from the CSP based features and g-gap dipeptide composition. Based on the optimal features, a Random Forest (RF) module is used to distinguish cis-Golgi proteins from trans-Golgi proteins. Through the jackknife cross-validation, the proposed method achieves a promising performance with a sensitivity of 0.889, a specificity of 0.880, an accuracy of 0.885, and a Matthew’s Correlation Coefficient (MCC) of 0.765, which remarkably outperforms previous methods. Moreover, when tested on a common independent dataset, our method also achieves a significantly improved performance. These results highlight the promising performance of the proposed method to identify Golgi-resident protein types. Furthermore, the CSP based feature extraction method may provide guidelines for protein function predictions.
THE REST-FRAME OPTICAL LUMINOSITY FUNCTION OF CLUSTER GALAXIES AT z < 0.8 AND THE ASSEMBLY OF THE CLUSTER RED SEQUENCE

We present the rest-frame optical luminosity function (LF) of red-sequence galaxies in 16 clusters at 0.4 < z < 0.8 drawn from the ESO Distant Cluster Survey (EDisCS). We compare our clusters to an analogous sample from the Sloan Digital Sky Survey (SDSS) and match the EDisCS clusters to their most likely descendants. We measure all LFs down to M ∼ M⋆ + (2.5–3.5). At z < 0.8, the bright end of the LF is consistent with passive evolution but there is a significant buildup of the faint end of the red sequence toward lower redshift. There is a weak dependence of the LF on cluster velocity dispersion for EDisCS but no such dependence for the SDSS clusters. We find tentative evidence that red-sequence galaxies brighter than a threshold magnitude are already in place, and that this threshold evolves to fainter magnitudes toward lower redshifts. We compare the EDisCS LFs with the LF of coeval red-sequence galaxies in the field and find that the bright end of the LFs agree. However, relative to the number of bright red galaxies, the field has more faint red galaxies than clusters at 0.6 < z < 0.8 but fewer at 0.4 < z < 0.6, implying differential evolution. We compare the total light in the EDisCS cluster red sequences to the total red-sequence light in our SDSS cluster sample. Clusters at 0.4 < z < 0.8 must increase their luminosity on the red sequence (and therefore stellar mass in red galaxies) by a factor of 1–3 by z = 0. The necessary processes that add mass to the red sequence in clusters predict local clusters that are overluminous as compared to those observed in the SDSS. The predicted cluster luminosities can be reconciled with observed local cluster luminosities by combining multiple previously known effects.
Coupled Generalized Nonlinear Stokes Flow with flow through a Porous Media

In this article, we analyze the flow of a fluid through a coupled Stokes-Darcy domain. The fluid in each domain is non-Newtonian, modeled by the generalized nonlinear Stokes equation in the free flow region and the generalized nonlinear Darcy equation in the porous medium. A flow rate is specified along the inflow portion of the free flow boundary. We show existence and uniqueness of a variational solution to the problem. We propose and analyze an approximation algorithm and establish a-priori error estimates for the approximation.