Miracle-dz/UniFAR-FTUs huggingface dataset:
Validity of the multidimensional fatigue symptom inventory-short form in an African-American community-based sample

Objectives. This study examined the psychometric properties of the Multidimensional Fatigue Symptom Inventory-Short Form (MFSI-SF) in a community-based sample of African-Americans. Design. A sample of 340 African-Americans (116 men, 224 women) ranging in age from 18–81 years were recruited from the community (e.g., churches, health fairs, and beauty salons). Participants completed a brief demographic survey, the MFSI-SF and the Positive and Negative Affect Schedule. Results. The structural validity of the MFSI-SF for a community-based sample of African-Americans was not supported. The five dimensions of fatigue (General, Emotional, Physical, Mental, Vigor) found for Whites in prior research were not found for African-Americans in this study. Instead, fatigue, while multidimensional for African-Americans, was best represented by a unique four-four profile in which general and emotional fatigue are collapsed into a single dimension and physical fatigue, mental fatigue, and vigor are relatively distinct. Hence, in the absence of modifications, the MFSI-SF cannot be considered to be structurally invariant across ethnic groups. A modified four-factor version of the MFSI-SF exhibited excellent internal consistency reliability and evidence supports its convergent validity. Using the modified four-factor version, gender, and age were not meaningfully associated with MFSI-SF scores. Conclusion. Future research should further examine whether modifications to the MFSI-SF would, as the findings suggest, improve its validity as a measure of multidimensional fatigue in African-Americans.
Race and Essentialism in Feminist Legal Theory

knew by heart the forms of the southern clouds at dawn on the 30th of April, 1882, and could compare them in his memory with the mottled streaks on a book in Spanish binding he had only seen once and with the outlines of the foam raised by an oar in the Rio Negro the night before the Quebracho uprising. These memories were not simple ones; each visual image was linked to muscular sensations, thermal sensations, etc. He could reconstruct all his dreams, all his half-dreams. Two or three times he had reconstructed a whole day; he never hesitated, but each reconstruction had required a whole day.3
Stereotactic radiotherapy for wet age-related macular degeneration: current perspectives

Neovascular age-related macular degeneration is a leading cause of blindness in the developed world. Currently, the treatment of choice is intravitreal injections of anti-VEGF medications. These require frequent dosing, up to monthly, and impose a substantial burden on patients and the health economy. Ionizing radiation was proposed as a possible treatment for age-related macular degeneration due to its anti-inflammatory and anti-fibrotic properties. Stereotactic radiotherapy is an outpatient-based radiotherapy platform that provides stereotactic application of low energy X-ray to the retina in three highly collimated beams that cross the inferior sclera to overlap at the macula. A randomized, double-masked, sham-controlled trial of 230 patients (INTREPID) showed that a single dose of stereotactic radiotherapy significantly reduces the number of intravitreal anti-VEGF injections needed over 2 years. A larger randomized controlled trial (STAR) is underway.
Family Structure as a Social Context for Family Conflict

Two major themes in the delinquency literature are the roles of family structure and childhood victimization. Combining these two lines of research, the current project examines the unique contribution of family structure and victimization on the serious delinquency of a nationally representative sample of adolescents. In addition, we examine whether the form of families serves to condition the relationship between victimization and delinquency. Past research indicates that abuse is more likely to occur in two-parent families of a “mixed” form, specifically in the presence of a live-in boyfriend or stepfather. However, little is known regarding the impact of victimization on delinquency across different types of family structure. Guided by a theoretical framework acknowledging that notions of justice influence the experience of victimization, our analyses indicate that, although victimization is more likely to occur in nonintact two-parent families, victimization is more likely to result in serious delinquency in intact families and single-parent families.
1.7 kV/1.0 mΩcm2 normally-off vertical GaN transistor on GaN substrate with regrown p-GaN/AlGaN/GaN semipolar gate structure

A normally-off vertical GaN-based transistor on a bulk GaN substrate with low specific on-state resistance of 1.0 mΩ·cm2 and high off-state breakdown voltage of 1.7 kV is presented. P-GaN/AlGaN/GaN triple layers are epitaxially regrown over V-shaped grooves formed over the drift layer. The channel utilizes so-called semi-polar face with reduced sheet carrier concentration at the AlGaN/GaN interface, which enables high threshold voltages of 2.5 V and stable switching operations. Note that formation of carbon-doped insulating GaN layer formed on p-GaN well layer underneath the channel suppresses the punch-through current at off-state between the source and drain, which enables good off-state characteristics. The fabricated high-current vertical transistor achieves successful fast switching at 400V/15A. These results indicate that the demonstrated vertical GaN transistor is very promising for future high power switching applications.
Comparison of Motor Development Between Twins and Singletons in Japan: A Population-Based Study

Abstract This study was performed using population-based data to analyze whether motor development in early life is different between singletons and twins in Japan. For better comparison and investigation, we divided the 2 groups into a group with a birthweight of 2.5 kg or greater (subgroup A) and a group with a birthweight of less than 2.5 kg (subgroup B), respectively. We analyzed the database of medical check-ups for children aged 3 years between April 2001 and July 2004. They received medical checkups at 4 months, 1.5, and 3 years of age. Children who were suspected of having neurological abnormality or disability were referred to specialists and excluded from the database. The data of 14,132 children were analyzed. Among these, 13,040 (92.3%) children were singletons in subgroup A, 75 (0.5%) were twins in subgroup A, 866 (6.1%) were singletons in subgroup B and 151 (1.1%) were twins in subgroup B. The mean age at achieving milestones was slower in twins of subgroup A for each developmental outcome than singletons of subgroup A, and the difference between twins and singletons was significant after adjustment for rolling over. On the contrary, after adjusting for a confounding factor (gestational age), singletons of subgroup B attained motor development facilitating walking independently slower than twins of subgroup B. There were different tendencies in the results regarding the motor development of subjects of subgroup A and that of subjects of subgroup B.
A simple dynamical model of intermittent fully developed turbulence

We present a phenomenological model of intermittency called the β-model and related to the Novikov-Stewart (1964) model. The key assumption is that in scales ∼ l02−n only a fraction βn of the total space has an appreciable excitation. The model, the idea of which owes much to Kraichnan (1972, 1974), is dynamical in the sense that we work entirely with inertial-range quantities such as velocity amplitudes, eddy turn-over times and energy transfer. This gives more physical insight than the traditional approach based on probabilistic models of the dissipation. The β-model leads in an elementary way to the concept of the self-similarity dimension D, a special case of Mandelbrot's (1974, 1976) ‘fractal dimension’. For three-dimensional turbulence, the correction B to the $\frac{5}{3}$ exponent of the energy spectrum is equal to $\frac{1}{3}(3 - D)$ and is related to the exponent μ of the dissipation correlation function by $B = \frac{1}{3}\mu $ (0.17 for the currently accepted value). This is a borderline case of the Mandelbrot inequality $B \leqslant \frac{1}{3}\mu $. It is shown in the appendix that this inequality may be derived from the Navier-Stokes equation under the strong, but plausible, assumption that the inertial-range scaling laws for second- and fourth-order moments have the same viscous cut-off. The predictions of the β-model for the spectrum and for higher-order statistics are in agreement with recent conjectures based on analogies with critical phenomena (Nelkin 1975) but generally diasgree with the 1962 Kolmogorov lognormal model. However, the sixth-order structure function 〈δv6(l)〉 and the dissipation correlation function 〈ε(r)ε(r + 1)〉 are related by \[ \langle \delta v^6(l)\rangle /l^2\sim\langle \epsilon({\bf r})\epsilon({\bf r}+{\bf l})\rangle \] in both models. We conjecture that this relation is model independent. Finally, some possible directions for further numerical and experimental work on intermittency are indicated.
One- to Four-Dimensional Kernels for Virtual Screening and the Prediction of Physical, Chemical, and Biological Properties

Many chemoinformatics applications, including high-throughput virtual screening, benefit from being able to rapidly predict the physical, chemical, and biological properties of small molecules to screen large repositories and identify suitable candidates. When training sets are available, machine learning methods provide an effective alternative to ab initio methods for these predictions. Here, we leverage rich molecular representations including 1D SMILES strings, 2D graphs of bonds, and 3D coordinates to derive efficient machine learning kernels to address regression problems. We further expand the library of available spectral kernels for small molecules developed for classification problems to include 2.5D surface and 3D kernels using Delaunay tetrahedrization and other techniques from computational geometry, 3D pharmacophore kernels, and 3.5D or 4D kernels capable of taking into account multiple molecular configurations, such as conformers. The kernels are comprehensively tested using cross-validation and redundancy-reduction methods on regression problems using several available data sets to predict boiling points, melting points, aqueous solubility, octanol/water partition coefficients, and biological activity with state-of-the art results. When sufficient training data are available, 2D spectral kernels in general tend to yield the best and most robust results, better than state-of-the art. On data sets containing thousands of molecules, the kernels achieve a squared correlation coefficient of 0.91 for aqueous solubility prediction and 0.94 for octanol/water partition coefficient prediction. Averaging over conformations improves the performance of kernels based on the three-dimensional structure of molecules, especially on challenging data sets. Kernel predictors for aqueous solubility (kSOL), LogP (kLOGP), and melting point (kMELT) are available over the Web through: http://cdb.ics. uci.edu.
doi:10.1068/p5638 Haptically straight lines

In this research, we set out to investigate haptically perceived space. Large deviations with respect to physical space have already been shown to exist. Here, research on haptic space is continued by investigating straight lines constructed by touch. In four experiments, subjects were asked to produce straight lines between two reference markers that were in the horizontal plane at a fixed distance from each other. Each experiment corresponded to a different task: two different interpolation tasks, an intersection task, and a pointing task. Straight lines had an orientation that was approximately frontoparallel. Subjects used both hands; manipulation was unrestricted. Although we found considerable differences between observers, the overall pattern of results showed that haptically straight lines were generally curved away from the observer. However, in one of the interpolation tasks they corresponded to physically straight lines. In addition, the pointing task generally produced larger deviations than the other three tasks. Taken together, the results show that there is no unique definition of the straight line, a conclusion that questions the viability of the concept of haptic space. doi:10.1068/p5638
Releasing the Imagination: Essays on Education, the Arts, and Social Change. The Jossey-Bass Education Series.

Introduction: A Quest for Meaning Part One: Creating Possibilities 1. Seeking Contexts 2. Imagination, Breakthroughs, and the Unexpected 3. Imagination, Community, and the School 4. Consciousness and the Public Space 5. Social Vision and the Dance of Life 6. The Shapes of Childhood Recalled Part Two: Imagination and Education 7. Blue Guitars and the Search for Curriculum 8. Writing to Learn 9. Teaching for Openings 10. Art and Imagination 11. Texts and Margins Part Three: Community in the Making 12. The Passions of Pluralism 13. Standards, Common Learnings, and Diversity 14. Multiple Voices and Multiple Realities.
Retinoid-Binding Proteins: Similar Protein Architectures Bind Similar Ligands via Completely Different Ways

Background Retinoids are a class of compounds that are chemically related to vitamin A, which is an essential nutrient that plays a key role in vision, cell growth and differentiation. In vivo, retinoids must bind with specific proteins to perform their necessary functions. Plasma retinol-binding protein (RBP) and epididymal retinoic acid binding protein (ERABP) carry retinoids in bodily fluids, while cellular retinol-binding proteins (CRBPs) and cellular retinoic acid-binding proteins (CRABPs) carry retinoids within cells. Interestingly, although all of these transport proteins possess similar structures, the modes of binding for the different retinoid ligands with their carrier proteins are different. Methodology/Principal Findings In this work, we analyzed the various retinoid transport mechanisms using structure and sequence comparisons, binding site analyses and molecular dynamics simulations. Our results show that in the same family of proteins and subcellular location, the orientation of a retinoid molecule within a binding protein is same, whereas when different families of proteins are considered, the orientation of the bound retinoid is completely different. In addition, none of the amino acid residues involved in ligand binding is conserved between the transport proteins. However, for each specific binding protein, the amino acids involved in the ligand binding are conserved. The results of this study allow us to propose a possible transport model for retinoids. Conclusions/Significance Our results reveal the differences in the binding modes between the different retinoid-binding proteins.
Adherence to Leukemia Maintenance Therapy: A Comparative Study Among Children, Adolescents, and Adults

This study describes patient adherence to leukemia maintenance therapy and the factors associated with nonadherence, with a particular focus on the different age groups concerned. Sixty-four in-depth interviews were performed in three centers among 31 parents of children, 12 parents of adolescents, 12 adolescents, and 9 adult patients. Adherence was determined through a multimethod approach based on patient and/or parent responses to three self-administered questions and patient and/or parent interviews. The results were compared with physician evaluation of adherence. Factors explaining nonadherence were investigated in the in-depth interviews and by statistical analysis of self-administered questionnaires. Intentional nonadherence occurred rarely (4/52 patients, 8%) following poor tolerance of the maintenance therapy. Despite a high motivation to follow the maintenance therapy, repeated forgetfulness (8/52, 15%) was not rare and rarely detected by physicians. Nonadherence increased with age, but also existed among children. Outings, the administration of therapy at bedtime, the lack of monitoring, a low socioeconomic status, and the hepatic side effects of the treatment were also associated with nonadherence. Declared nonadherence of leukemia maintenance therapy is not negligible and should be screened at follow-up consultations using three simple questions.
Sustaining proactive motivation for non-mandatory professional development building self-determined employees

This dissertation examined the motivations energising employees' participation in non-mandatory professional development (PD) provided within their work organisation using a proactive motivation framework (Parker, Bindl, & Strauss, 2010) and a Self-Determination Theory (Deci & Ryan, 1985) perspective. Two studies were conducted using a mixed-method design. Study 1 was conducted in a specific organisation and involved both quantitative and qualitative data. Both aspects of this study informed the development of the quantitative Study 2 conducted in an organisation non-specific sample. The quantitative aspect of both Study 1 and Study 2 provided support for a structural model of employees‟ motivation to participate in non-mandatory PD within their work organisation as a proactive, self-determined process that includes transfer implementation intentions as a pre-participation commitment toward change and readiness to transfer what is learned. Study 1 demonstrated that employees' Transfer Implementation Intentions were energised by autonomous motivation for participation in non-mandatory PD and the intrinsic benefits envisioned from participation. As an organisational context variable, positive work environment directly influenced each aspect of the model. From the Study 1 qualitative findings it was concluded that organisational commitment to employee development, useful to job, useful to career, and prosocial benefits were important variables to include in the structural model tested in Study 2. Study 2 demonstrated that employees‟ transfer implementation intentions were influenced by both intrinsic benefits and prosocial benefits. Autonomous motivation demonstrated only an indirect influence on transfer implementation intentions. An organisational commitment to development influenced employees‟ perceptions of useful to career and useful to job. Useful to job influenced autonomous motivation and prosocial benefits, while useful to career influenced intrinsic benefits. Together, the results of the two studies highlight the importance of autonomous motivation, intrinsic and prosocial goals, and the provision of organisational support to facilitate employees‟ proactive involvement in non-mandatory PD and their intention to transfer what is learned. These influences are important, as participation and the use of what is learned are paramount to the success of non-mandatory PD activities (Goldstein & Ford, 2002).
Neural Entrainment and Sensorimotor Synchronization to the Beat in Children with Developmental Dyslexia: An EEG Study

Tapping in time to a metronome beat (hereafter beat synchronization) shows considerable variability in child populations, and individual differences in beat synchronization are reliably related to reading development. Children with developmental dyslexia show impairments in beat synchronization. These impairments may reflect deficiencies in auditory perception of the beat which in turn affect auditory-motor mapping, or may reflect an independent motor deficit. Here, we used a new methodology in EEG based on measuring beat-related steady-state evoked potentials (SS-EPs, Nozaradan et al., 2015) in an attempt to disentangle neural sensory and motor contributions to behavioral beat synchronization in children with dyslexia. Children tapped with both their left and right hands to every second beat of a metronome pulse delivered at 2.4 Hz, or listened passively to the beat. Analyses of preferred phase in EEG showed that the children with dyslexia had a significantly different preferred phase compared to control children in all conditions. Regarding SS-EPs, the groups differed significantly for the passive Auditory listening condition at 2.4 Hz, and showed a trend toward a difference in the Right hand tapping condition at 3.6 Hz (sensorimotor integration measure). The data suggest that neural rhythmic entrainment is atypical in children with dyslexia for both an auditory beat and during sensorimotor coupling (tapping). The data are relevant to a growing literature suggesting that rhythm-based interventions may help language processing in children with developmental disorders of language learning.
Alteration of Cardiac Progenitor Cell Potency in GRMD Dogs

Among the animal models of Duchenne muscular dystrophy (DMD), the Golden Retriever muscular dystrophy (GRMD) dog is considered the best model in terms of size and pathological onset of the disease. As in human patients presenting with DMD or Becker muscular dystrophies (BMD), the GRMD is related to a spontaneous X-linked mutation of dystrophin and is characterized by myocardial lesions. In this respect, GRMD is a useful model to explore cardiac pathogenesis and for the development of therapeutic protocols. To investigate whether cardiac progenitor cells (CPCs) isolated from healthy and GRMD dogs may differentiate into myocardial cell types and to test the feasibility of cell therapy for cardiomyopathies in a preclinical model of DMD, CPCs were isolated from cardiac biopsies of healthy and GRMD dogs. Gene profile analysis revealed an active cardiac transcription network in both healthy and GRMD CPCs. However, GRMD CPCs showed impaired self- renewal and cardiac differentiation. Population doubling and telomerase analyses highlighted earlier senescence and proliferation impairment in progenitors isolated from GRMD cardiac biopsies. Immunofluorescence analysis revealed that only wt CPCs showed efficient although not terminal cardiac differentiation, consistent with the upregulation of cardiac-specific proteins and microRNAs. Thus, the pathological condition adversely influences the cardiomyogenic differentiation potential of cardiac progenitors. Using PiggyBac transposon technology we marked CPCs for nuclear dsRed expression, providing a stable nonviral gene marking method for in vivo tracing of CPCs. Xenotransplantation experiments in neonatal immunodeficient mice revealed a valuable contribution of CPCs to cardiomyogenesis with homing differences between wt and dystrophic progenitors. These results suggest that cardiac degeneration in dystrophinopathies may account for the progressive exhaustion of local cardiac progenitors and shed light on cardiac stemness in physiological and pathological conditions. Furthermore, we provide essential information that canine CPCs may be used to alleviate cardiac involvement in a large preclinical model of DMD.