Miracle-dz/UniFAR-FTUs huggingface dataset:
Density evolution and power profile optimization for iterative multiuser decoders based on individually optimum multiuser detectors

Iterative multiuser joint decoding based on exact Belief Propagation (BP) is analyzed in the large system limit by means of the replica method. It is shown that performance can be improved by appropriate power assignment to the users. The optimum power assignment can be found by linear programming in most technically relevant cases. The performance of BP iterative multiuser joint decoding is compared to suboptimum approximations based on Interference Cancellation (IC). While IC receivers show a significant loss for equal-power users, they yield performance close to BP under optimum power assignment.
When Do We Really Need Coronary Calcium Scoring Prior to Contrast-Enhanced Coronary Computed Tomography Angiography? Analysis by Age, Gender and Coronary Risk Factors

Aims To investigate the value of coronary calcium scoring (CCS) as a filter scan prior to coronary computed tomography angiography (CCTA). Methods and Results Between February 2008 and April 2011, 732 consecutive patients underwent clinically indicated CCTA. During this ‘control phase’, CCS was performed in all patients. In patients with CCS≥800, CCTA was not performed. During a subsequent ‘CCTA phase’ (May 2011–May 2012) another 200 consecutive patients underwent CCTA, and CCS was performed only in patients with increased probability for severe calcification according to age, gender and atherogenic risk factors. In patients where CCS was not performed, calcium scoring was performed in contrast-enhanced CCTA images. Significant associations were noted between CCS and age (r = 0.30, p<0.001) and coronary risk factors (χ2 = 37.9; HR = 2.2; 95%CI = 1.7–2.9, p<0.001). Based on these associations, a ≤3% pre-test probability for CCS≥800 was observed for males <61 yrs. and females <79 yrs. According to these criteria, CCS was not performed in 106 of 200 (53%) patients during the ‘CCTA phase’, including 47 (42%) males and 59 (67%) females. This resulted in absolute radiation saving of ∼1 mSv in 75% of patients younger than 60 yrs. Of 106 patients where CCS was not performed, estimated calcium scoring was indeed <800 in 101 (95%) cases. Non-diagnostic image quality due to calcification was similar between the ‘control phase’ and the ‘CCTA’ group (0.25% versus 0.40%, p = NS). Conclusion The value of CCS as a filter for identification of a high calcium score is limited in younger patients with intermediate risk profile. Omitting CCS in such patients can contribute to further dose reduction with cardiac CT studies.
Interplay between Endophyte Prevalence, Effects and Transmission: Insights from a Natural Grass Population

Two main mechanisms are thought to affect the prevalence of endophyte-grass symbiosis in host populations: the mode of endophyte transmission, and the fitness differential between symbiotic and non-symbiotic plants. These mechanisms have mostly been studied in synthetic grass populations. If we are to improve our understanding of the ecological and evolutionary dynamics of such symbioses, we now need to determine the combinations of mechanisms actually operating in the wild, in populations shaped by evolutionary history. We used a demographic population modeling approach to identify the mechanisms operating in a natural stand of an intermediate population (i.e. 50% of plants symbiotic) of the native grass Festuca eskia. We recorded demographic data in the wild over a period of three years, with manipulation of the soil resources for half the population. We developed two stage-structured matrix population models. The first model concerned either symbiotic or non-symbiotic plants. The second model included both symbiotic and non-symbiotic plants and took endophyte transmission rates into account. According to our models, symbiotic had a significantly higher population growth rate than non-symbiotic plants, and endophyte prevalence was about 58%. Endophyte transmission rates were about 0.67 or 0.87, depending on the growth stage considered. In the presence of nutrient supplementation, population growth rates were still significantly higher for symbiotic than for non-symbiotic plants, but endophyte prevalence fell to 0%. At vertical transmission rates below 0.10–0.20, no symbiosis was observed. Our models showed that a positive benefit of the endophyte and vertical transmission rates of about 0.6 could lead to the coexistence of symbiotic and non-symbiotic F. eskia plants. The positive effect of the symbiont on host is not systematically associated with high transmission rates of the symbiont over short time scales, in particular following an environmental change.
A closed-form model predictive control framework for nonlinear noise-corrupted systems

In this paper, a framework for Nonlinear Model Predictive Control (NMPC) that explicitly incorporates the noise influence on systems with continuous state spaces is introduced. By the incorporation of noise, which results from uncertainties during model identification and the measurement process, the quality of control can be significantly increased. Since NMPC requires the prediction of system states over a certain horizon, an efficient state prediction technique for nonlinear noise-affected systems is required. This is achieved by using transition densities approximated by axis-aligned Gaussian mixtures together with methods to reduce the computational burden. A versatile cost function representation also employing Gaussian mixtures provides an increased freedom of modeling. Combining the prediction technique with this value function representation allows closed-form calculation of the necessary optimization problems arising from NMPC. The capabilities of the framework and especially the benefits that can be gained by considering the noise in the controller are illustrated by the example of a mobile robot following a given path.
Mesenchymal Stem Cells Promote Diabetic Corneal Epithelial Wound Healing Through TSG-6-Dependent Stem Cell Activation and Macrophage Switch.

Purpose To explore the role and mechanism of bone marrow-derived mesenchymal stem cells (BM-MSCs) in corneal epithelial wound healing in type 1 diabetic mice. Methods Diabetic mice were treated with subconjunctival injections of BM-MSCs or recombinant tumor necrosis factor-α-stimulated gene/protein-6 (TSG-6). The corneal epithelial wound healing rate was examined by fluorescein staining. The mRNA and protein expression levels of TSG-6 were measured by quantitative RT-PCR and Western blot. The infiltrations of leukocytes and macrophages were analyzed by flow cytometry and immunofluoresence staining. The effect of TSG-6 was further evaluated in cultured limbal epithelial stem/progenitor cells, macrophages, and diabetic mice by short hairpin RNA (shRNA) knockdown. Results Local MSC transplantation significantly promoted diabetic corneal epithelial wound healing, accompanied by elevated corneal TSG-6 expression, increased corneal epithelial cell proliferation, and attenuated inflammatory response. Moreover, in cultured human limbal epithelial stem/progenitor cells, TSG-6 enhanced the colony-forming efficiency, stimulated mitogenic proliferation, and upregulated the expression level of ΔNp63. Furthermore, in diabetic mouse cornea and in vitro macrophage culture, TSG-6 alleviated leukocyte infiltration and promoted the polarization of recruited macrophages to anti-inflammatory M2 phenotypes with increased phagocytotic capacity. In addition, the promotion of epithelial stem/progenitor cell activation and macrophage polarization by MSC transplantation was largely abrogated by shRNA knockdown of TSG-6. Conclusions This study provided the first evidence of TSG-6 secreted by MSCs promoting corneal epithelial wound healing in diabetic mice through activating corneal epithelial stem/progenitor cells and accelerating M2 macrophage polarization.
An Improved Model for the Steric-Entropic Effect on the Retention of Rod-like Particles in Field-Flow Fractionation: Discussion of Aspect Ratio-Based Separation

We developed an improved model for predicting the steric-entropic effect on the separation behaviors of rod-like particles in flow field-flow fractionation. Our new model incorporates the “pole-vault” rotation of a rod-like particle near a wall under shear flow into the original model developed by Beckett and Giddings which considered only Brownian rotation. We investigated the effect of the aspect ratio on the retention ratios and the cross-sectional concentration distribution in the separation of rods in field-flow fractionation (FFF). Our analyses involved comparing the results predicted using the original model and those from the new model under various rod geometries and flow conditions. We found that the new model can show the aspect ratio-enhanced elution trend in certain flow conditions for the assumption of non-constant cloud thickness (ratio between the cross flow rate and the rod diffusivity). We also deducted that the flow conditions allowing for the aspect ratio-enhanced elution are related to the interplay among the axial flow rate, cloud thickness, and rod geometry. The new model can be viewed as a prototype to qualitatively show the aspect ratio-enhanced trend since its quantitative agreement with the experimental data must be improved for our future work.
Symbolic model checking of UML activity diagrams

Two translations from activity diagrams to the input language of NuSMV, a symbolic model verifier, are presented. Both translations map an activity diagram into a finite state machine and are inspired by existing statechart semantics. The requirements-level translation defines state machines that can be efficiently verified, but are a bit unrealistic since they assume the perfect synchrony hypothesis. The implementation-level translation defines state machines that cannot be verified so efficiently, but that are more realistic since they do not use the perfect synchrony hypothesis. To justify the use of the requirements-level translation, we show that for a large class of activity diagrams and certain properties, both translations are equivalent: regardless of which translation is used, the outcome of model checking is the same. Moreover, for linear stuttering-closed properties, the implementation-level translation is equivalent to a slightly modified version of the requirements-level translation. We use the two translations to model check data integrity constraints for an activity diagram and a set of class diagrams that specify the data manipulated in the activities. Both translations have been implemented in two tools. We discuss our experiences in applying both translations to model check some large example activity diagrams.
High-Quality Draft Whole-Genome Sequences of 162 Salmonella enterica subsp. enterica Serovar Enteritidis Strains Isolated from Diverse Sources in Canada

ABSTRACT We report the high-quality draft genome sequences of 162 strains of Salmonella enterica subsp. enterica serovar Enteritidis representing diverse phage types and pulsed-field gel electrophoresis (PFGE) profiles. The analysis of these genomes will enable the identification of markers that are useful for differentiating strains of this highly clonal serovar and will provide insights into the evolution, virulence, and epidemiology of the strains.
Multiple Query Optimization on the D-Wave 2X Adiabatic Quantum Computer

The D-Wave adiabatic quantum annealer solves hard combinatorial optimization problems leveraging quantum physics. The newest version features over 1000 qubits and was released in August 2015. We were given access to such a machine, currently hosted at NASA Ames Research Center in California, to explore the potential for hard optimization problems that arise in the context of databases. In this paper, we tackle the problem of multiple query optimization (MQO). We show how an MQO problem instance can be transformed into a mathematical formula that complies with the restrictive input format accepted by the quantum annealer. This formula is translated into weights on and between qubits such that the configuration minimizing the input formula can be found via a process called adiabatic quantum annealing. We analyze the asymptotic growth rate of the number of required qubits in the MQO problem dimensions as the number of qubits is currently the main factor restricting applicability. We experimentally compare the performance of the quantum annealer against other MQO algorithms executed on a traditional computer. While the problem sizes that can be treated are currently limited, we already find a class of problem instances where the quantum annealer is three orders of magnitude faster than other approaches.
Cellulosic Materials: Fibers, Networks and Composites

Part I The Challenge of nanotechnology. - The Radical Vision of Nanotechnology - An Introduction. - Our Nanotechnological Future: What Should we Worry About. - Part 2 Self-Assembly and Biomimetics in Cellulosics. - Why Cellulose. - Cell Wall Nanostructure. - Nanostructure Characterization and Properties. - Nanocrystalline Cellulose Extraction. - Optical Properties of Chiral Nematic (Cellulosic) Liquid Crystals. - Part 3 Development of Functional Bionanomaterials. - The Reinforcement Potential of Cellulose Nanofibrils. - Nano-Reinforced Cellulose Systems: Nanocomposites and Biopolymers. - Applications of Cellulose Nanomaterials. - Health, Safety and Economic Issues
Barium hexaferrite reinforced polymeric dye composite coatings for radar absorbing applications

Radar is an electronic and electromagnetic system that uses radio waves to detect and locate objects. Against this system, especially for certain military applications focused on defence and security, radar absorbing materials are required. There are many advanced techniques used for absorbing optimisation. In this study barium hexaferrite was used to produce a radar absorbing composite material. In this sense, an epoxy dye was converted to a radar absorbing coating. Barium hexaferrite powders produced by means of sol–gel method were added to a polymer matrix (dye) with different loading levels to see the concentration dependence of particles' radar absorbing effect. Different types of samples were prepared by coating glass substrates with a polymer matrix loaded with various amount of barium hexaferrites. Samples were characterized by Fourier Transform Infrared (FTIR) and Scanning Electron Microscope-Energy Dispersive Spectroscopy (SEM-EDS). Under applied magnetic field, the produced composites exhibited the hysteresis loops of the ferromagnetic behavior with vibrating sample magnetometer (VSM). The saturation magnetization and coercivity of nanocomposites were obtained. In addition, radar absorbing test were applied as a primary objective of this research with a network analyzer. It was concluded that the barium hexaferrite reinforced composites have electromagnetic properties which indicates potential application in high performance adsorbing materials and it was indicated that increasing barium hexaferrite powder amount in the composites leads to increase radar absorbing performance. POLYM. COMPOS. , 35:602–610, 2014. © 2013 Society of Plastics Engineers
Food-derived bioactive peptides--opportunities for designing future foods.

Dietary proteins are known to carry a wide range of nutritional, functional and biological properties. Nutritionally, the proteins are a source of energy and amino acids, which are essential for growth and maintenance. Functionally, the proteins contribute to the physicochemical and sensory properties of various protein-rich foods. Furthermore, many dietary proteins possess specific biological properties which make these components potential ingredients of functional or health-promoting foods. Many of these properties are attributed to physiologically active peptides encrypted in protein molecules. Particularly rich sources of such peptides are milk and egg, but they are also found in meat of various kinds as well as many plants. These peptides are inactive within the sequence of parent protein and can be released during gastrointestinal digestion or food processing. Depending on the amino acid sequence, these peptides may exert a number of different activities in vivo, affecting, e.g., the cardiovascular, endocrine, immune and nervous systems in addition to nutrient utilization. There is increasing commercial interest in the production of bioactive peptides from various sources. Industrial-scale production of such peptides is, however, hampered by the lack of suitable technologies. Bioactive peptides can also be produced from milk proteins through fermentation of milk, by starters employed in the manufacture of fermented milks or cheese. In particular, antihypertensive peptides have been identified in fermented milk, whey and ripened cheese. A few of these peptides have been commercialised in the form of fermented milks. There is a need to develop technologies which retain or even enhance the activity of bioactive peptides in food systems. Also, it is essential to study the optimum utilization of such peptides during passage through the gastrointestinal tract.
The latent human herpesvirus-6A genome specifically integrates in telomeres of human chromosomes in vivo and in vitro

Previous research has suggested that human herpesvirus-6 (HHV-6) may integrate into host cell chromosomes and be vertically transmitted in the germ line, but the evidence—primarily fluorescence in situ hybridization (FISH)—is indirect. We sought, first, to definitively test these two hypotheses. Peripheral blood mononuclear cells (PBMCs) were isolated from families in which several members, including at least one parent and child, had unusually high copy numbers of HHV-6 DNA per milliliter of blood. FISH confirmed that HHV-6 DNA colocalized with telomeric regions of one allele on chromosomes 17p13.3, 18q23, and 22q13.3, and that the integration site was identical among members of the same family. Integration of the HHV-6 genome into TTAGGG telomere repeats was confirmed by additional methods and sequencing of the integration site. Partial sequencing of the viral genome identified the same integrated HHV-6A strain within members of families, confirming vertical transmission of the viral genome. We next asked whether HHV-6A infection of naïve cell lines could lead to integration. Following infection of naïve Jjhan and HEK-293 cell lines by HHV-6, the virus integrated into telomeres. Reactivation of integrated HHV-6A virus from individuals’ PBMCs as well as cell lines was successfully accomplished by compounds known to induce latent herpesvirus replication. Finally, no circular episomal forms were detected even by PCR. Taken together, the data suggest that HHV-6 is unique among human herpesviruses: it specifically and efficiently integrates into telomeres of chromosomes during latency rather than forming episomes, and the integrated viral genome is capable of producing virions.
Characteristics and prognoses of patients treated by an anaesthesiologist-manned prehospital emergency care unit. A retrospective cohort study

Objective When planning and dimensioning an emergency medical system, knowledge of the population serviced is vital. The amount of literature concerning the prehospital population is sparse. In order to add to the current body of literature regarding prehospital treatment, thus aiding future public health planning, we describe the workload of a prehospital anaesthesiologist-manned mobile emergency care unit (MECU) and the total population it services in terms of factors associated with mortality. Participants The study is a register-based study investigating all missions carried out by a MECU operating in a mixed urban/rural area in Denmark from 1 May 2006 to 31 December 2014. Information on missions was extracted from the local MECU registry and linked at the individual level to the Danish population-based databases, the National Patient Registry and the Civil Registration System. Primary and secondary outcome measures Primary outcome measures were number of missions and number of patient contacts. Secondary patient variables were mortality and association between mortality and age, sex, comorbidity, prior admission to hospital and response time. Results The MECU completed 41 513 missions (mean 13.1 missions/day) having 32 873 patient contacts, corresponding to 19.2 missions and 15.2 patient encounters per 1000 patient years. Patient variables: the median age was 57 years (range 0–108 years), 42.8% (42.3% to 43.4%) were women. For patients admitted to hospital alive, 30-day mortality was 5.7% (5.4% to 6.0%); 90-day mortality was 8.1% (7.8% to 8.5%) while 2-year mortality was 16.4% (16.0% to 16.8%). Increasing age, male sex, comorbidity and prior admission to hospital but not response time were associated with mortality. Conclusions Mortality following an incident requiring the assistance of a MECU was high in the first 2 years following the incident. MECU response time assessed as a continuous parameter was not associated with patient outcome.
Electro-Structured Fluid Seals

The aim of this paper is to bring together various works on concentrically located rotating shaft seals which utilise electro-structured fluid sealant, in order to produce a generalised approach to their design, thus resolving seemingly incompatible reports on the effects of rotational speed on sealing capabilities. In turn, the results from these works are reviewed, a viscoplastic analysis of the 2-D problem is presented and the effects on leakage rate of radius ratio, rotational speed and axial pressure gradient as they interact with fluid properties are illustrated.
coeliac disease . T cell depletion in untreated adult

Thymus dependant lymphocytes (T cells) may be involved in the pathogenesis of the jejunal lesion in coeliac disease (Ferguson, 1974). In addition, impaired function of circulating lymphocytes, probably T cells, occurs in this disorder (Blecher et al., 1969; McClaurin et al., 1971). The numbers of circulating T lymphocytes in coeliac disease might have an important bearing upon these phenomena. The aim of this study, therefore, was to quantitate peripheral blood cells that spontaneously form rosettes with sheep red cells which are considered to represent the T cell subpopulation (Jondal et al., 1972; Wybran et al., 1973). The findings have been correlated with dietary treatment and lymphocyte populations of the jejunal mucosa in an attempt to elucidate the possible role ofT cells in coeliac disease.