Miracle-dz/UniFAR-FTUs huggingface dataset:
Cytomorphologic Study of Hashimoto’s Thyroiditis and Its Serologic Correlation

OBJECTIVE To analyze the cytomorphologic spectrum of Hashimoto's thyroiditis (HT) on fine needle aspiration cytology (FNAC) and to correlate cytologic findings with serologic parameters STUDY DESIGN One hundred fifty patients diagnosed with HT on FNAC were subjected to serologic studies. A detailed cytologic examination was done with an attempt to grade thyroiditis, lymphoid:epithelial (L:E) ratio and intensity of lymphocytic infiltrates. Any additional lesion or feature seen in association with HT was recorded. Thyroid hormonal assay and thyroid antibodies were evaluated using appropriate methods. Cytologic findings were correlated with the serologic parameters and analyzed using the chi2 test and Fisher's exact test. RESULTS Apart from the usual cytomorphologic spectrum of HT, significant findings recorded in a fair number of cases were abundant colloid, follicular hyperplasia, fire flares, eosinophils and HT-associated neoplasms. Grading of thyroiditis and lymphocytic infiltration showed no correlation with the clinical severity of HT, while a high L:E ratio was strongly correlated with thyroid peroxidase positivity (p = 0.004). Presence of fire flares and macrophages correlated positively with hyperthyroidism, with p values of 0.002 and 0.005, respectively. Thyroid peroxidase positivity showed a strong association with HT (p = 0.001) as compared to HT coexisting with follicular hyperplasia/Hashitoxicosis/neoplasm. CONCLUSION The present study gives an account of the cytomorphologic spectrum of a large series of HT cases, with its serologic correlation, emphasizing the importance of a careful interpretation of fine needle aspiration smears in the presence of colloid, follicular hyperplasia or a coexisting neoplasm.
Clinical impact of intraoperative CCEP monitoring in evaluating the dorsal language white matter pathway

In order to preserve postoperative language function, we recently proposed a new intraoperative method to monitor the integrity of the dorsal language pathway (arcuate fasciculus; AF) using cortico–cortical evoked potentials (CCEPs). Based on further investigations (20 patients, 21 CCEP investigations), including patients who were not suitable for awake surgery (five CCEP investigations) or those without preoperative neuroimaging data (eight CCEP investigations including four with untraceable tractography due to brain edema), we attempted to clarify the clinical impact of this new intraoperative method. We monitored the integrity of AF by stimulating the anterior perisylvian language area (AL) by recording CCEPs from the posterior perisylvian language area (PL) consecutively during both general anesthesia and awake condition. After tumor resection, single‐pulse electrical stimuli were also applied to the floor of the removal cavity to record subcortico‐cortical evoked potentials (SCEPs) at AL and PL in 12 patients (12 SCEP investigations). We demonstrated that (1) intraoperative dorsal language network monitoring was feasible even when patients were not suitable for awake surgery or without preoperative neuroimaging studies, (2) CCEP is a dynamic marker of functional connectivity or integrity of AF, and CCEP N1 amplitude could even become larger after reduction of brain edema, (3) a 50% CCEP N1 amplitude decline might be a cut‐off value to prevent permanent language dysfunction due to impairment of AF, (4) a correspondence (<2.0 ms difference) of N1 onset latencies between CCEP and the sum of SCEPs indicates close proximity of the subcortical stimulus site to AF (<3.0 mm). Hum Brain Mapp 38:1977–1991, 2017. © 2017 Wiley Periodicals, Inc.
Supporting Families Living With Dementia in Rural Areas.

BACKGROUND Family members caring for persons with dementia are subject to multiple types of stress. Psychosocial help is recommended to lighten the emotional burden of care and can be of use in stabilizing the home-care situation. In this study conducted in rural areas in Germany, we tested whether volunteers with a special qualification for the assistance of families caring for dementia patients can support family members more effectively than conventional care companions. METHODS In a randomized, controlled trial, 63 family members caring for persons with dementia were aided by specially qualified family companions (experimental intervention) or by conventional care companions (control intervention). The family members' quality of life was the primary endpoint and was evaluated at the end of the study in an intention-to-treat (ITT) analysis with t-tests. In an additional per-protocol (PP) analysis, differences that arose between groups at the outset of the study were accounted for. Secondary endpoints included reduced stress and better integration into the support system. RESULTS The ITT analysis revealed no differences between groups in healthrelated quality of life on either the emotional or the somatic scale. The PP analysis, however, showed that the experimental intervention improved the emotional health-related quality of life of the patients' family members compared to the control group. The effect strength was intermediate (d = 0.57; p = 0.047). CONCLUSION The difference between the findings of the PP and ITT analyses may be explained in part by the different distribution of severity of dementia in the two groups (experimental and control).
Rarely Encountered, Seldom Considered: Posterior Tibial Nerve Schwannoma Mimicking Lumbar Radiculopathy

Sir, A 63‐year‐old female presented with progressively increasing pain in the right leg and foot along the S1 dermatome and dysesthesias for 3 years duration. There was no history of back pain, and the leg pain was unrelated to posture and activity and even occurred at rest. A magnetic resonance imaging (MRI) of the spine was noncontributory, and she was treated with medications, physiotherapy and even an epidural block without any relief. Six months ago, she noted a swelling in the posterolateral aspect of her right lower limb, palpation of which was painful. An MRI of the right leg showed an enhancing tumor probably arising from posterior tibial nerve deep to the tendoachilles and superficial to the deep flexors in the posterior compartment of the leg [Figure 1]. On examination, the swelling was ill‐defined and tender. There were no motor or sensory deficits.
Improving the Accuracy of Urban Environmental Quality Assessment Using Geographically-Weighted Regression Techniques

Urban Environmental Quality (UEQ) can be treated as a generic indicator that objectively represents the physical and socio-economic condition of the urban and built environment. The value of UEQ illustrates a sense of satisfaction to its population through assessing different environmental, urban and socio-economic parameters. This paper elucidates the use of the Geographic Information System (GIS), Principal Component Analysis (PCA) and Geographically-Weighted Regression (GWR) techniques to integrate various parameters and estimate the UEQ of two major cities in Ontario, Canada. Remote sensing, GIS and census data were first obtained to derive various environmental, urban and socio-economic parameters. The aforementioned techniques were used to integrate all of these environmental, urban and socio-economic parameters. Three key indicators, including family income, higher level of education and land value, were used as a reference to validate the outcomes derived from the integration techniques. The results were evaluated by assessing the relationship between the extracted UEQ results and the reference layers. Initial findings showed that the GWR with the spatial lag model represents an improved precision and accuracy by up to 20% with respect to those derived by using GIS overlay and PCA techniques for the City of Toronto and the City of Ottawa. The findings of the research can help the authorities and decision makers to understand the empirical relationships among environmental factors, urban morphology and real estate and decide for more environmental justice.
A carboxyl-terminal interaction of lamin B1 is dependent on the CAAX endoprotease Rce1 and carboxymethylation

The mammalian nuclear lamina protein lamin B1 is posttranslationally modified by farnesylation, endoproteolysis, and carboxymethylation at a carboxyl-terminal CAAX motif. In this work, we demonstrate that the CAAX endoprotease Rce1 is required for lamin B1 endoproteolysis, demonstrate an independent pool of proteolyzed but nonmethylated lamin B1, as well as fully processed lamin B1, in interphase nuclei, and show a role for methylation in the organization of lamin B1 into domains of the nuclear lamina. Deficiency in the endoproteolysis or methylation of lamin B1 results in loss of integrity and deformity of the nuclear lamina. These data show that the organization of the nuclear envelope and lamina is dependent on a mechanism involving the methylation of lamin B1, and they identify a potential mechanism of laminopathy involving a B-type lamin.
Diabetic retinopathy studied by fluorescein angiography.

THE INTRODUCTION OF RETINAL ANGIOGRAPHY has given the physician the opportunity to study and permanently record morphology and physiology in the living ocular vascular system. Specifically, flow and permeability in the retinal and choroidal vessels can now be correlated with anatomical changes. Other publications have described the normal fluorescein pattern," 9 the changes that occur in mass lesions of the macular hypertension,5 and occlusive disease of the carotid and retinal vessels.9 The purpose of this paper is to report our preliminaiy observations in the study of a small of diabetic patients, to compare these observations with those of others, and to indicate the possible value of this technique in the study of diabetic retinopathy.
Pyrogenic organic matter production from wildfires: a missing sink in the global carbon cycle

Wildfires release substantial quantities of carbon (C) into the atmosphere but they also convert part of the burnt biomass into pyrogenic organic matter (PyOM). This is richer in C and, overall, more resistant to environmental degradation than the original biomass, and, therefore, PyOM production is an efficient mechanism for C sequestration. The magnitude of this C sink, however, remains poorly quantified, and current production estimates, which suggest that ~1‐5% of the C affected by fire is converted to PyOM, are based on incomplete inventories. Here, we quantify, for the first time, the complete range of PyOM components found in‐situ immediately after a typical boreal forest fire. We utilized an experimental high‐intensity crown fire in a jack pine forest (Pinus banksiana) and carried out a detailed pre‐ and postfire inventory and quantification of all fuel components, and the PyOM (i.e., all visually charred, blackened materials) produced in each of them. Our results show that, overall, 27.6% of the C affected by fire was retained in PyOM (4.8 ± 0.8 t C ha−1), rather than emitted to the atmosphere (12.6 ± 4.5 t C ha−1). The conversion rates varied substantially between fuel components. For down wood and bark, over half of the C affected was converted to PyOM, whereas for forest floor it was only one quarter, and less than a tenth for needles. If the overall conversion rate found here were applicable to boreal wildfire in general, it would translate into a PyOM production of ~100 Tg C yr−1 by wildfire in the global boreal regions, more than five times the amount estimated previously. Our findings suggest that PyOM production from boreal wildfires, and potentially also from other fire‐prone ecosystems, may have been underestimated and that its quantitative importance as a C sink warrants its inclusion in the global C budget estimates.
Dynamic characterization of viscoelastic materials used in composite structures

The main focus of this paper is the experimental comparative analysis of the viscoelastic properties of acrylic- and silicon-based viscoelastic materials. These materials are widely used in the aeronautic industry for structural and/or damping applications. It is therefore required to determine their viscoelastic properties such as shear modulus and loss factor following their integration to aircraft composite structures. The influence of material thickness, bonding quality, curing and cocuring with composite material was evaluated using dynamic mechanical analysis machine in plan shear configuration. This comparative analysis in the 0–600 Hz frequency range provides useful information that should be taken into consideration when designing bonded joints for structural and/or damping applications. The small variation of the acrylic-based material loss factor over a wide range of frequencies suggests that this material is a good candidate for damping applications at room temperature in metallic structures where no curing is required. However, cocuring of acrylic-based material with composite laminae increases its shear modulus up to six times with respect to the uncured material whereas its loss factor is reduced by about 20%. On the other hand, the silicon-based material remains stable after thermal treatment (curing and cocuring) suggesting that it is well suited for in situ damping treatment involving laminate composite structure. However, at room temperature its shear modulus after cocuring is lowered by almost 25% due to poor bonding quality, which depends on the nature of the substrate.
The therapeutic effectiveness of using visual art modalities with the bereaved: a systematic review

Bereaved individuals are increasingly considered at risk for negative psychological and physiological outcomes. Visual art modalities are often incorporated into grief therapy interventions, and clinical application of art therapy techniques with the bereaved has been widely documented. Although clinicians and recipients of these interventions advocate for their helpfulness in adapting to bereavement, research investigating the efficacy of visual art modalities has produced equivocal results and has not yet been synthesized to establish empirical support across settings. Accordingly, this review critically evaluates the existent literature on the effectiveness of visual art modalities with the bereaved and offers suggestions for future avenues of research. A total of 27 studies were included in the current review. Meta-analysis was not possible because of clinical heterogeneity and insufficient comparable data on outcome measures across studies. A narrative synthesis reports that therapeutic application of visual art modalities was associated with positive changes such as continuing bonds with the deceased and meaning making. Modest and conflicting preliminary evidence was found to support treatment effectiveness in alleviating negative grief symptoms such as general distress, functional impairment, and symptoms of depression and anxiety.
Dissimilarity of contemporary and historical gene flow in a wild carrot (Daucus carota) metapopulation under contrasting levels of human disturbance: implications for risk assessment and management of transgene introgression.

BACKGROUND AND AIMS Transgene introgression from crops into wild relatives may increase the resistance of wild plants to herbicides, insects, etc. The chance of transgene introgression depends not only on the rate of hybridization and the establishment of hybrids in local wild populations, but also on the metapopulation dynamics of the wild relative. The aim of the study was to estimate gene flow in a metapopulation for assessing and managing the risks of transgene introgression. METHODS Wild carrots (Daucus carota) were sampled from 12 patches in a metapopulation. Eleven microsatellites were used to genotype wild carrots. Genetic structure was estimated based on the FST statistic. Contemporary (over the last several generations) and historical (over many generations) gene flow was estimated with assignment and coalescent methods, respectively. KEY RESULTS The genetic structure in the wild carrot metapopulation was moderate (FST = 0·082) and most of the genetic variation resided within patches. A pattern of isolation by distance was detected, suggesting that most of the gene flow occurred between neighbouring patches (≤1 km). The mean contemporary gene flow was 5 times higher than the historical estimate, and the correlation between them was very low. Moreover, the contemporary gene flow in roadsides was twice that in a nature reserve, and the correlation between contemporary and historical estimates was much higher in the nature reserve. Mowing of roadsides may contribute to the increase in contemporary gene flow. Simulations demonstrated that the higher contemporary gene flow could accelerate the process of transgene introgression in the metapopulation. CONCLUSIONS Human disturbance such as mowing may alter gene flow patterns in wild populations, affecting the metapopulation dynamics of wild plants and the processes of transgene introgression in the metapopulation. The risk assessment and management of transgene introgression and the control of weeds need to take metapopulation dynamics into consideration.
Longitudinal Changes in the Corpus Callosum Following Pediatric Traumatic Brain Injury as Assessed by Volumetric MRI and Diffusion Tensor Imaging

Longitudinal Changes In The Corpus Callosum Following Pediatric Traumatic Brain Injury Trevor C. Wu Department of Psychology Doctor of Philosophy Atrophy of the corpus callosum (CC) is a documented consequence of moderate-to-severe traumatic brain injury (TBI), which has been expressed as volume loss using quantitative magnetic resonance imaging (MRI). Other advanced imaging modalities such as diffusion tensor imaging (DTI) have also detected white matter microstructural alteration following TBI in the CC. The manner and degree to which macrostructural changes such as volume and microstructural changes develop over time following pediatric TBI and their relation to a measure of processing speed is the focus of this longitudinal investigation. As such, DTI and volumetric changes of the CC in participants with TBI and a comparison group at approximately three and 18 months post injury and their relation to processing speed were determined.
Effects of Social Norms Information and Self-Affirmation on Sugar-Sweetened Beverage Consumption Intentions and Behaviors

ABSTRACT The separate and combined efficacy of a social norms and a self-affirmation intervention to motivate decreased sugar-sweetened beverage (SSB) consumption was examined in 2 experiments. College students were randomly assigned to receive information about SSB consumption risks, norms, both, or neither. In addition, participants performed either a self-affirmation or control task. Self-affirmation only weakly affected SSB consumption intentions and behaviors. However, participants in Experiment 2 who received risks information, norms information, or both reported greater SSB reduction intentions than did those who received no information. Two weeks later, those who received both types of information reported more frequent behavior change preparations, and it appears this effect may have been partially mediated by the changes in intentions to reduce SSB consumption.
Scattered wave imaging of the oceanic plate in Cascadia

Scattered waves image discontinuities beneath Cascadia that are likely caused by melt beneath the young oceanic plate. Fifty years after plate tectonic theory was developed, the defining mechanism of the plate is still widely debated. The relatively short, simple history of young ocean lithosphere makes it an ideal place to determine the property that defines a plate, yet the remoteness and harshness of the seafloor have made precise imaging challenging. We use S-to-P receiver functions to image discontinuities beneath newly formed lithosphere at the Juan de Fuca and Gorda Ridges. We image a strong negative discontinuity at the base of the plate increasing from 20 to 45 km depth beneath the 0- to 10-million-year-old seafloor and a positive discontinuity at the onset of melting at 90 to 130 km depth. Comparison with geodynamic models and experimental constraints indicates that the observed discontinuities cannot easily be reconciled with subsolidus mechanisms. Instead, partial melt may be required, which would decrease mantle viscosity and define the young oceanic plate.
Effect of Dietary Chestnut or Quebracho Tannin Supplementation on Microbial Community and Fatty Acid Profile in the Rumen of Dairy Ewes

Ruminants derived products have a prominent role in diets and economy worldwide; therefore, the capability to control the rumen microbial ecosystem, for ameliorating their quality, is of fundamental importance in the livestock sector. The aim of this study was to evaluate the effect of dietary supplementation with chestnut and quebracho tannins on microbial community and fatty acid profile, in the rumen fluid of dairy ewes. Multivariate analysis of PCR-DGGE profiles of rumen microbial communities showed a correlation among the presence of chestnut or quebracho in the diet, the specific Butyrivibrio group DGGE profiles, the increase in 18:3 cis9, cis12, and cis15; 18:2 cis9 and cis12; 18:2 cis9 and trans11; 18:2 trans11 and cis15; and 18:1 trans11 content, and the decrease in 18:0 concentration. Phylogenetic analysis of DGGE band sequences revealed the presence of bacteria representatives related to the genera Hungatella, Ruminococcus, and Eubacterium and unclassified Lachnospiraceae family members, suggesting that these taxa could be affected by tannins presence in the diets. The results of this study showed that tannins from chestnut and quebracho can reduce the biohydrogenation of unsaturated fatty acids through changes in rumen microbial communities.
miR-155 Inhibits Mouse Osteoblast Differentiation by Suppressing SMAD5 Expression

Osteogenesis from preosteoblasts is important for bone tissue engineering. MicroRNAs are a class of endogenous small RNA molecules that potentially modulate osteogenesis. In this study, we found that miR-155 expression was downregulated in a time-dependent manner in cells of the preosteoblast cell line MC3T3-E1 after osteogenic induction using bone morphogenetic protein 2 (BMP2). Transfection with miR-155 decreased alkaline phosphatase (ALP) activity, ALP expression, and the staining intensity of Alizarin Red in MC3T3-E1 cells treated with BMP2, whereas treatment with miR-155 inhibitor promoted BMP2-induced osteoblast differentiation. The luciferase assay confirmed that miR-155 can bind to the 3′ untranslated region of SMAD5 mRNA. miR-155 transfection significantly decreased the expression of SMAD5 protein and mRNA in MC3T3-E1 cells under control media and the p-SMAD5 protein level during osteogenesis. After transfecting cells with the SMAD5 overexpression plasmids, the inhibitory effect of miR-155 on osteogenesis was significantly attenuated. In conclusion, miR-155 inhibited osteoblast differentiation by downregulating the translation of SMAD5 in mouse preosteoblast cells. Inhibition of miR-155 promoted osteogenic potential and thus it can be used as a potential target in the treatment of bone defects.
Draft Whole-Genome Sequences of Zhihengliuella halotolerans La12 and Microbacterium kitamiense Sa12, Strains with Cellulase Activity, Isolated from the Qinghai-Tibetan Plateau

ABSTRACT We report the complete genome sequences of cellulolytic strains Zhihengliuella halotolerans La12 and Microbacterium kitamiense Sa12, which were isolated from soil samples collected from the Qinghai-Tibetan Plateau in Western China. The final assemblies of La12 and Sa12 comprise 3,712,694 bp, with over 111 contigs, and 3,830,439 bp, with over 39 contigs, respectively.