Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of fixed orthodontic treatment on gingival health: An observational study

: Objective : The purpose of this study was to evaluate the association of orthodontic treatment and fixed retainers with gingival health. Design: observational study. Place of Study : This study was conducted at Dental unit of Abbasi Shaheed Hospital Karachi Patient(s): The study comprised of 80 patients who came in dental clinic for routine dental examination between the time period of August 2017 to August 2018. Procedure: Plaque and gingival indices, gingival recession, probing depth, and bleeding on probing were measured at the anterior sextants. In the presence of fixed retainer, the distance was measured. It measured between the retainer and incised edge and to the cemento-enamel junction. Past orthodontic treatment and smoking habits were self-reported. By the presence or absence of fixed retainers, Post orthodontic patients were sorted. Main Outcome Measure(s): gingival health Result(s): The mean probing depth was 1.90 – 0.2 mm, and gingival recession was 0.06 – 0.02 mm; 20.8% of all sites exhibited bleeding on probing. Current smoking was reported by 20 (21.7%) patients. Labial gingival recession was significantly greater in treated (0.13 – 0.2 mm) patients compared to non-treated patients (0.05 – 0.2 mm; P = 0.03). Patients with fixed retainers Localized lingual gingival recession was significantly greater in teeth (0.09 – 0.2 mm) as compared to patient’s teeth with no fixed retainers (0.01 – 0.1 mm; P = 0.0002), as were plaque and gingival indices and bleeding on probing. A weak, positive correlation was showed by Plaque on the lingual/palatal aspect with lingual gingival recession (r = 0.16; P = 0.033). Conclusion: Orthodontic treatment is significantly associated in increased destruction of the periodontal structures.
Genetic dissection of the developmental behaviours of plant height in wheat under diverse water regimes

Plant height (PH), a crucial trait related to yield potential in crop plants, is known to be typically quantitatively inherited. However, its full expression can be inhibited by a limited water supply. In this study, the genetic basis of the developmental behaviour of PH was assessed in a 150-line wheat (Triticum aestivum L.) doubled haploid population (Hanxuan 10×Lumai 14) grown in 10 environments (year×site×water regime combinations) by unconditional and conditional quantitative trait locus (QTL) analyses in a mixed linear model. Genes that were expressed selectively during ontogeny were identified. No single QTL was continually active in all periods of PH growth, and QTLs with additive effects (A-QTLs) expressed in the period S1|S0 (the period from the original point to the jointing stage) formed a foundation for PH development. Additive main effects (a effects), which were mostly expressed in S1|S0, were more important than epistatic main effects (aa effects) or QTL×environment interaction (QE) effects, suggesting that S1|S0 was the most significant development period affecting PH growth. A few QTLs, such as QPh.cgb-6B.7, showed high adaptability for water-limited environments. Many QTLs, including four A-QTLs (QPh.cgb-2D.1, QPh.cgb-4B.1, QPh.cgb-4D.1, and QPh.cgb-5A.7) coincident with previously identified reduced height (Rht) genes (Rht8, Rht1, Rht2, and Rht9), interacted with more than one other QTL, indicating that the genetic architecture underlying PH development is a network of genes with additive and epistatic effects. Therefore, based on multilocus combinations in S1|S0, superior genotypes were predicted for guiding improvements in breeding for PH.
The QUEST RR Lyrae Survey. II. The Halo Overdensities in the First Catalog

The first catalog of the RR Lyrae stars (RRLSs) in the Galactic halo by the Quasar Equatorial Survey Team (QUEST) has been searched for significant overdensities that may be debris from disrupted dwarf galaxies or globular clusters. These RRLSs are contained in a band ∼2. °3 wide in declination that spans ∼165° in right ascension and lie ∼4 to ∼60 kpc from the Sun. Away from the major overdensities, the distribution of these stars is adequately fitted by a smooth halo model, in which the flattening of the halo decreases with increasing galactocentric distance (as reported by Preston et al.). This model was used to estimate the "background" of RRLSs on which the halo overdensities are overlaid. A procedure was developed for recognizing groups of stars that constitute significant overdensities with respect to this background. To test this procedure, a Monte Carlo routine was used to make artificial RRLS surveys that follow the smooth halo model but with Poisson-distributed noise in the numbers of RRLSs and, within limits, random variations in the positions and magnitudes of the artificial stars. The 104 artificial surveys created by this routine were examined for significant groups in exactly the same way as the QUEST survey. These calculations provided estimates of the frequencies with which random fluctuations produce significant groups. In the QUEST survey there are six significant overdensities that contain six or more stars and several smaller ones. The small ones and possibly one or two of the larger ones may be artifacts of statistical fluctuations, and they need to be confirmed by measurements of radial velocity and/or proper motion. The most prominent groups are the northern stream from the Sagittarius dwarf spheroidal galaxy and a large group in Virgo, formerly known as the "12.4 hr clump," which Duffau and coworkers have recently shown to contain a stellar stream (the Virgo stellar stream). Two other groups lie in the direction of the Monoceros stream and at approximately the right distance for membership. Another group is related to the globular cluster Palomar 5.
Air temperature changes in Serbia and the Belgrade heat island

Climatic regionalization of Serbia was performed in the paper on the basis of data on air temperature from 23 meteorological stations and using cluster analysis. Applying Mann-Kendall test and Sen's slope estimates, temperature linear trends were investigated within each of the clusters, but also at each station individually. It has been shown that a positive linear trend is present in practically entire territory of Serbia and that it is very strong in Belgrade. Differences in air temperature between Belgrade and the cluster in which it is located were examined on an annual basis.
Evaluation of color intensity enhanced by paprika as feed additive in goldfish and koi carp using computer-assisted image analysis

: Body color intensity of red-colored koi carp Cyprinus carpio and goldfish Carassius auratus auratus varieties were measured to evaluate the effect of paprika used as a feed additive. Digital photos of the experimental fish were processed and analyzed by using special software. The red, green and blue (RGB) values of images were recorded and grayscale values of R, G and B were analyzed. The RGB values seem to play different roles in the development of the visible ‘redness’ of the two species. In most cases the B values decreased continuously during the administration of the paprika as a carotenoid feed additive, which seemed to have no effect on this process. The G values remained unchanged or decreased slightly as redness increased due to paprika feeding. The R values had a tendency to increase due to paprika feeding but significant differences can be expected only after 4 weeks at the feeding conditions applied here. Both the initial rate of redness and genetic background are thought to influence the rate of red color intensity change, which was observed to be different in the two fish species studied here.
A multi-proxy lacustrine record of last deglacial–early Holocene environmental variability in the lower Yangtze region from the Chaohu Lake Basin, eastern China

Abstract The Rb, Sr, and Ti content, Rb/Sr ratio, grain size, magnetic susceptibility, and magnetic fabric in sediments of the BZK1 core were utilized to reconstruct the evolution of the climatic environment in the Chaohu Lake Basin between the last deglacial and the early Holocene. Multi-proxy analyses indicate that lacustrine sediments in Chaohu Lake clearly record the Bølling-Allerød interstadial, the Younger Dryas event and dry-cold climate events occurring between 10.7 cal ka BP and 10.5 cal ka BP. At approximately 15.6–14.8 cal ka BP, the waters became deeper and the climate turned cool. The climate subsequently shifted to a relatively humid period and the lake was largest from 14.8 to 12.8 cal ka BP. From 12.8 to 11.7 cal ka BP, the climate abruptly turned dry and cold and the lake shrank to its lowest level. During 11.7–10.7 cal ka BP, the climate became relatively humid but, from approximately 10.7 to 10.5 cal ka BP, suddenly reverted to a dry and cold state. These climatic change records suggest that lacustrine sediments from the Chaohu Lake Basin in the lower Yangtze region responded actively to global climate changes, comparable with the environmental records from stalagmites and other lacustrine sediments in the region.
Family Support and Loneliness among Older Persons in Multiethnic Malaysia

This study investigates factors affecting older persons' state of loneliness in multiethnic Malaysia using data from the 2004 Malaysian Population and Family Survey, the first nationally representative sample in Malaysia. The study sample was extracted to include Malays, Chinese, Indians and other Indigenous groups aged 60 and above, and who had children (n = 1791). Cross tabulations and ordinal logistic regression methods were used in the analysis. Among the ethnic groups, older Malays were more likely than their Chinese and Indian counterparts to experience loneliness. Loneliness was found to be associated with age, marital status, education level, sources of income, health status, and physical limitations. Among older people, feelings of loneliness were inversely related with coresidence with adult children and participation in religious activities. Sociodemographic changes have eroded the traditional family support system for the elderly, while social security remains inadequate. This study shows the important role of family in alleviating loneliness among older people. Hence the need to promote and facilitate coresidence, as well as participation in religious activities, and a healthy lifestyle as a priority strategy is in line with the objectives of the National Policy for the Older People.
The EHR's roles in collaboration between providers: A qualitative study

OBJECTIVE Examine how the Electronic Health Record (EHR) and its related systems support or inhibit provider collaboration. BACKGROUND Health care systems in the US are simultaneously implementing EHRs and transitioning to more collaborative delivery systems; this study examines the interaction between these two changes. METHODS This qualitative study of five US EHR implementations included 49 interviews and over 60 hours of provider observation. We examined the role of the EHR in building relationships, communicating, coordinating, and collaborative decision-making. RESULTS The EHR plays four roles in collaboration: a repository, a messenger, an orchestrator, and a monitor. While EHR performance varied, common themes were decreased trust due to poor quality documentation, incomplete communication, potential for increased effectiveness through better coordination, and the emerging role of the EHR in identifying performance gaps. CONCLUSION Both organizational and technical innovations are needed if the EHR is to truly support collaborative behaviors.
Transistor-level static timing analysis by piecewise quadratic waveform matching

While fast timing analysis methods, such as asymptotic waveform evaluation (AWE), have been well established for linear circuits, the timing analysis for non-linear circuits, which are dominant in digital CMOS circuits, is usually, performed by a SPICE like, time domain integration based approach, involving expensive Newton Raphson iterations at numerous time steps. In this paper we propose a new technique that leads to the transient solution of charge/discharge paths with a complexity equivalent to only K DC operating point calculations, where K is the number of transistors along the path. This is accomplished by approximating each nodal voltage as a piecewise quadratic waveform, whose characteristics can be determined by matching the charge/discharge currents. Experiments on a wide range of circuits show that a 31.6 times speed-up over SPICE transient simulation with 10 ps step size can be achieved, while maintaining an average accuracy of 99%.
On the implementation of pfair-scheduled multiprocessor systems

The goal of this dissertation is to extend the Pfair scheduling approach in order to enable its efficient implementation on a real-time multiprocessor. At present, Pfair scheduling is the only known means for optimally scheduling recurrent real-time tasks on multiprocessors. In addition, there has been growing practical interest in such approaches due to their fairness guarantees. Unfortunately, prior work in this area has considered only the scheduling of independent tasks, which do not communicate with each other or share resources. The work presented herein focuses both on adding support for these actions and also on developing techniques for reducing various forms of implementation overhead, including that produced by task migrations and context switches. The thesis of this dissertation is: tasks can be efficiently synchronized in Pfair-scheduled systems and overhead due to common system events, such as context switches and migrations, can be reduced. This thesis is established through research in three areas. First, the pre-existing Pfair scheduling theory is extended to support the scheduling of groups of tasks as a single entity. Second, mechanisms for supporting both lock-based and lock-free synchronization are presented. Lock-based synchronization coordinates access to shared resources through the use of semaphores. On the other hand, lock-free operations are optimistically attempted and then retried if the operation fails. Last, the deployment of Pfair scheduling on a symmetric multiprocessor is considered.
Major LOXL1 risk allele is reversed in exfoliation glaucoma in a black South African population

Purpose To investigate whether variants in the lysyl oxidase-like 1 (LOXL1) gene are associated with exfoliation glaucoma (XFG) and primary open-angle glaucoma (POAG) in an ancestral population from South Africa. Methods Black South African subjects with XFG, POAG, and age matched unaffected controls were recruited from the St. John Eye Hospital in Soweto, Johannesburg, South Africa, using standard clinical examination techniques. Fifty individuals were collected for each of the three groups: XFG, POAG, and normal controls. The complete coding region of LOXL1 was sequenced using the PCR-based Sanger method. The allele frequencies of the identified sequence variants were compared between XFG or POAG and controls using Fisher’s exact test. Results A large number of coding variants were identified, including rs1048661 (R141L), rs3825942 (G153D), S159A, S161L, rs41435250 (A320A), rs13329473 (F489F), and T567A. The allele frequencies of both rs3825942 and rs1048661 differed significantly between the XFG and control subjects from South Africa (p=5.2×10−13 and 1.7×10−5, respectively). The G allele for rs1048661 (encoding arginine) was the risk allele which is similar to other populations. The A allele of rs3825942 (encoding aspartic acid) was the risk allele, in sharp contrast to the G allele (encoding glycine) reported in multiple other populations. There was no significant difference in the allele frequencies of coding variants in LOXL1 between POAG and control subjects. Conclusions This represents the first genetic association study of LOXL1 in an ancestral African population with XFG. We have confirmed the association between variants of LOXL1 and XFG. To date, the G allele of the major susceptibility variant rs3825942 has consistently been shown in multiple populations to increase the risk of XFG. Surprisingly, we have found a strong association with the opposite allele in the South African population. This suggests that other as yet unknown causal variants of LOXL1 contribute to the genetic risk of XFG.
Agomelatine, a melatonin agonist with antidepressant properties

Agomelatine (β-methyl-6-chloromelatonin), which is structurally homologous to melatonin, is a potent agonist of melatonin MT1 and MT2 receptors as well as an antagonist of serotonin 5-HT2C receptors. Agomelatine appears to improve sleep without causing daytime sedation. It has not been found to be associated with sexual side effects and discontinuation symptoms. Three placebo-controlled trials, one of them a dose finding study and two of them pivotal trials, suggest that agomelatine is an antidepressant at doses of 25 – 50 mg/day. Agomelatine appears to be well tolerated, without sexual or cardiac adverse effects, weight gain or discontinuation syndromes. Animal studies suggest a possible neuroprotective action of agomelatine, although there are more data in favor of an anxiolytic effect. Substantially more research is needed to establish its role in the treatment of mood and circadian rhythm disorders.
Interpreting improvement in expiratory flows after lung volume reduction surgery in terms of flow limitation theory.

Spirometry and pulmonary mechanics were measured pre- and postoperatively in 37 patients undergoing bilateral lung volume reduction surgery (LVRS). The relative contributions of changes in compliance (CL), recoil pressures (PTLC), small airway conductance (Gu), and airway closing pressures (Ptm') to changes in expiratory flows were examined with a Taylor series expansion of the Pride- Permutt model of flow limitation. The resulting variational expression, deltaVmax = GudeltaPel + PeldeltaGu - GudeltaPtm' - Ptm'deltaGu - deltaGudeltaPtm', was then used to describe how the peak flow rate (Vmax) depends on preoperative Gu, P TLC, Ptm', and on changes (delta) in these parameters after surgery. After LVRS, both FEV(1) and Vmax increased significantly ( DeltaFEV(1) = 28 +/- 44%; DeltaVmax = 78 +/- 132%), and changes in FEV(1) and Vmax correlated closely (r = 0.74, p < 0.001). Among responders (DeltaFEV(1) > or = 12%; n = 19; DeltaFEV(1) = 60 +/- 38%), PTLC increased (8.8 +/- 2.8 to 12.2 +/- 4.7 cm H2O) and the time constant for expiration (tau = CL/Gu) decreased (2.67 +/- 0.62 to 2.35 +/- 0.55 s), while Ptm', CL, and Gu did not change. GudeltaPel, the change in recoil weighted by preoperative conductance upstream of the flow-limiting site, accounted for 72% of the improvement in Vmax. Among nonresponders ( DeltaFEV(1) = -6 +/- 15%, n = 18), tau increased significantly, contributing to a decline in FEV(1)/FVC ratio. PeldeltaGu decreased (-0.25 +/- 0.68, p = 0.013), accounting for all of the decline in Vmax. This analysis suggests that (1) improvement in expiratory flows after LVRS is largely due to increases in recoil pressure; (2) large improvements in FEV(1) can occur without changes in Gu or Ptm', arguing that LVRS has little effect on airway resistance or closure; and (3) large changes in PTLC can occur without changes in CL, supporting arguments of Fessler and Permutt (Am J Respir Crit Care Med 1998;157:715-722) that "resizing of the lung to chest wall" is the primary mechanism by which LVRS improves lung function.
Lateral specialization of cognitive mode: an EEG study.

We have studied EEG asymmetry in normal subjects during verbal and spatial tasks. Recordings were made from the left and right temporal and parietal areas, and the ratios of average power (1–35 Hz) in homologous leads T4/T3 and P4/P3 were computed. This ratio (right over left) was greater in the verbal tasks than in the spatial tasks. With this measure we have been able to distinguish between these two cognitive modes as they occur in normal subjects, using simple scalp recording.
Interchromosomal Transfer of Immune Regulation During Infection of Barley with the Powdery Mildew Pathogen

Powdery mildew pathogens colonize over 9500 plant species, causing critical yield loss. The Ascomycete fungus, Blumeria graminis f. sp. hordei (Bgh), causes powdery mildew disease in barley (Hordeum vulgare L.). Successful infection begins with penetration of host epidermal cells, culminating in haustorial feeding structures, facilitating delivery of fungal effectors to the plant and exchange of nutrients from host to pathogen. We used expression Quantitative Trait Locus (eQTL) analysis to dissect the temporal control of immunity-associated gene expression in a doubled haploid barley population challenged with Bgh. Two highly significant regions possessing trans eQTL were identified near the telomeric ends of chromosomes (Chr) 2HL and 1HS. Within these regions reside diverse resistance loci derived from barley landrace H. laevigatum (MlLa) and H. vulgare cv. Algerian (Mla1), which associate with the altered expression of 961 and 3296 genes during fungal penetration of the host and haustorial development, respectively. Regulatory control of transcript levels for 299 of the 961 genes is reprioritized from MlLa on 2HL to Mla1 on 1HS as infection progresses, with 292 of the 299 alternating the allele responsible for higher expression, including Adaptin Protein-2 subunit μ AP2M and Vesicle Associated Membrane Protein VAMP72 subfamily members VAMP721/722. AP2M mediates effector-triggered immunity (ETI) via endocytosis of plasma membrane receptor components. VAMP721/722 and SNAP33 form a Soluble N-ethylmaleimide-sensitive factor Attachment Protein REceptor (SNARE) complex with SYP121 (PEN1), which is engaged in pathogen associated molecular pattern (PAMP)-triggered immunity via exocytosis. We postulate that genes regulated by alternate chromosomal positions are repurposed as part of a conserved immune complex to respond to different pathogen attack scenarios.
Topography of the western Pacific LLSVP constrained by S-wave multipathing

S U M M A R Y We found that SHdiff phases generated by earthquakes in the Fiji–Tonga, recorded in India, are accompanied by secondary pulses. We interpreted them as a consequence of multipathing of S waves caused by the Pacific large low-shear-velocity province (LLSVP). We analysed the differential traveltimes between SHdiff and the secondary pulse, together with the absolute SHdiff arrival times, to constrain the thickness and velocity perturbations in the western end of the Pacific LLSVP. Our preferred model shows a lateral variation in the thickness of the LLSVP; the southern part reveals a thicker (300 km) low-velocity region compared to the northern part (200 km). However, the velocity perturbations of the LLSVP appear to be comparable (−1.5 per cent). The results are consistent with a scenario that the LLSVP is a chemically distinct pile with significant surface topography.
Simultaneous Determination of Firm Leverage and Private Benefits of Control in French Firms

This study investigates whether the firm leverage breed private benefits of control in France ; or that is private benefits of control that drive the firm financing policy. Most French firms are family-owned and highly concentrated and hence the controlling power of block-shareholders. Private benefits of control are particularly high in France. They can be extracted by both large shareholders through related-party transactions and managers via their compensation. If debt effectively curbs the private benefits of control, the controlling party is also given incentives to increase debt. Using a sample of 110 listed firms during 2002-2006, our modeling puts in evidence a simultaneous relationship between firm leverage and the private benefits of control. Empirical results reveal that debt is positively associated with related party-transactions but negatively related with excessive managerial compensation. The controlling shareholders are tempted to increase the firm leverage so as to increase their own private benefits. The manager however wants to maintain his private benefits already siphoned off and aims therefore at reducing the firm debt.