Miracle-dz/UniFAR-FTUs huggingface dataset:
Safety and Efficacy of Mini Open Transforaminal Lumbar Interbody Fusion

Objective Mini-transforaminal lumbar interbody fusion (Mini-TLIF) and other minimally invasive approaches introduced for the purpose of treating lumbar degenerative disc disease and instability are achieving high success and safety rates as the conventional approaches. Moreover, it has less soft tissue damage, minimal blood loss, and less hospital stay. Methods A prospective study was conducted from 2012 to 2014 on 28 patients who were subjected to Mini-open TLIF combined with transpedicular screw fixation for spondylolisthesis and degenerative disc disease. Two paramedian approaches were done, 4 cm for each, to insert the pedicular screws, along with inserting unilateral TLIF cage with autologous bone graft. Decompression was done either unilateral or bilateral according to the patient side of radiculopathy. Sixteen patients (57.2%) were diagnosed with degenerative spondylolisthesis, 7 patients (25%) were diagnosed with isthmic type spondylolisthesis, and 5 patients (17.8%) were diagnosed with degenerative disc disease, 2 of them(7.1%) had previous operations at the same level. Twenty patients (71.4%) were operated at the L4/5 level, and 8 patients (28.6%) at the L5/S1 level. Results All patients were able to ambulate the next day of surgery. The mean estimated blood loss was 251.79mL. The average hospital stay was 4.14 days. The average follow-up was 9 months. The mean visual analog scale was 1.86 at discharge, 1.68 after 3 months, and 1.38 after 6 months. After 6 months of the operation, MacNab's criteria were good in 23 patients and excellent in 5 patients. We had one case with transient weakness, 2 cases of screw malposition without clinical manifestations, and one case of infection. Conclusion Mini-TLIF approach is an efficient and safe approach for treating instability and degenerative diseases of the lumbar spine. The clinical outcome is encouraging and it may be an operation of choice for lumbar spinal fusion in selected patients.
Executive control over unconscious cognition: attentional sensitization of unconscious information processing

Unconscious priming is a prototypical example of an automatic process, which is initiated without deliberate intention. Classical theories of automaticity assume that such unconscious automatic processes occur in a purely bottom-up driven fashion independent of executive control mechanisms. In contrast to these classical theories, our attentional sensitization model of unconscious information processing proposes that unconscious processing is susceptible to executive control and is only elicited if the cognitive system is configured accordingly. It is assumed that unconscious processing depends on attentional amplification of task-congruent processing pathways as a function of task sets. This article provides an overview of the latest research on executive control influences on unconscious information processing. I introduce refined theories of automaticity with a particular focus on the attentional sensitization model of unconscious cognition which is specifically developed to account for various attentional influences on different types of unconscious information processing. In support of the attentional sensitization model, empirical evidence is reviewed demonstrating executive control influences on unconscious cognition in the domains of visuo-motor and semantic processing: subliminal priming depends on attentional resources, is susceptible to stimulus expectations and is influenced by action intentions and task sets. This suggests that even unconscious processing is flexible and context-dependent as a function of higher-level executive control settings. I discuss that the assumption of attentional sensitization of unconscious information processing can accommodate conflicting findings regarding the automaticity of processes in many areas of cognition and emotion. This theoretical view has the potential to stimulate future research on executive control of unconscious processing in healthy and clinical populations.
Current transport of leatherback sea turtles (Dermochelys coriacea) in the ocean

While the long-distance movements of pelagic vertebrates are becoming known thanks to satellite telemetry, the factors determining their courses have hardly been investigated. We have analysed the effects of oceanographic factors on the post-nesting movements of three satellite-tracked leatherback turtles (Dermochelys coriacea) moving in the southwest Indian Ocean. By superimposing the turtle tracks on contemporaneous images of sea-surface temperatures and sea height anomalies, we show that currentrelated features dominate the shape of the reconstructed routes. After an initial offshore movement, turtles moved along straight routes when in the core of the current, or executed loops within eddies. Large parts of the routes were strikingly similar to those of surface drifters tracked in the same region. These findings document that long-lasting oceanic movements of marine turtles may be shaped by oceanic currents.
Morphometric analysis of smooth muscle in the anterior vaginal wall of women with pelvic organ prolapse.

OBJECTIVE The purpose of this study was to compare the smooth muscle content of the anterior vaginal wall in normal women and women with pelvic organ prolapse. STUDY DESIGN Specimens were taken from the apex of the anterior vaginal cuff after abdominal hysterectomy from 28 women with pelvic organ prolapse and 12 control subjects. Smooth muscle cells of the anterior vaginal wall were identified by immunohistochemistry with antibodies to smooth muscle alpha-actin. Morphometric analysis was used to determine the fractional area of nonvascular smooth muscle in the muscularis in histologic cross-sections of the anterior vaginal wall. RESULTS The fractional area of nonvascular vaginal smooth muscle in the muscularis of women with prolapse was significantly decreased compared with that of control subjects. This decreased fraction of smooth muscle in the anterior vaginal wall was not related to age, race, or stage of prolapse. In women with prolapse, vaginal smooth muscle content was most diminished in specimens from postmenopausal women with no estrogen replacement. The fractional area of muscularis smooth muscle was also decreased significantly in premenopausal women with prolapse. CONCLUSION The fraction of smooth muscle in the muscularis of the anterior vaginal wall is significantly decreased in women with pelvic organ prolapse compared with normal control subjects.
Does Corporate Diversification Destroy Value?

We analyze several hundred firms that expand via acquisition and0or increase their number of business segments. The combined market reaction to acquisition announcements is positive but acquiring firm excess values decline after the diversifying event. Much of the excess value reduction occurs because our sample firms acquire already discounted business units, and not because diversifying destroys value. This implies that the standard assumption that conglomerate divisions can be benchmarked to typical stand-alone f irms should be carefully reconsidered. We also show that excess value does not decline when firms increase their number of business segments because of pure reporting changes. DOES CORPORATE DIVERSIF ICATION destroy value? Several recent papers attempt to answer this question by comparing the market value of firms that operate multiple lines of business to the value of a portfolio of stand-alone firms operating in the same industries as the conglomerate’s divisions. Lang and Stulz ~1994! use this approach and find that multisegment firms have low values of Tobin’s q compared to stand-alone firms. Similarly, Berger and Ofek ~1995! find that U.S. conglomerates are priced at a mean discount of about 15 percent. Lins and Servaes ~1999! find similar discounts in Japan and the United Kingdom. Indeed, based on the Berger and Ofek methodology, diversified firms with valuation discounts had aggregate value losses of $800 billion in 1995. The magnitude of the value loss suggests that operating the divisions of conglomerates as stand-alone firms would create significant value. In this paper, we provide new evidence on whether the act of corporate diversification destroys value, or whether the divisions that make up conglomerates would trade at a discount, even if they operated as standalone firms.
Anomaly Detection for a Water Treatment System Using Unsupervised Machine Learning

In this paper, we propose and evaluate the application of unsupervised machine learning to anomaly detection for a Cyber-Physical System (CPS). We compare two methods: Deep Neural Networks (DNN) adapted to time series data generated by a CPS, and one-class Support Vector Machines (SVM). These methods are evaluated against data from the Secure Water Treatment (SWaT) testbed, a scaled-down but fully operational raw water purification plant. For both methods, we first train detectors using a log generated by SWaT operating under normal conditions. Then, we evaluate the performance of both methods using a log generated by SWaT operating under 36 different attack scenarios. We find that our DNN generates fewer false positives than our one-class SVM while our SVM detects slightly more anomalies. Overall, our DNN has a slightly better F measure than our SVM. We discuss the characteristics of the DNN and one-class SVM used in this experiment, and compare the advantages and disadvantages of the two methods.
Sediment Dynamics and Wave-current Interactions

Described here is a model for the long-time formation and evolution of erodible beds under the action of waves and currents. It is an extention of a model rst developed by Craik and Leibovich, which describes the dynamics of Langmuir circulation cells, later adapted by McWilliams and Restrepo to model the interaction of a gravity wave eld with global oceanic ows.
Advertising in a Competitive Market: The Role of Product Standards, Customer Learning, and Switching Costs

Standard models of competition predict that firms will sell less when competitors target their customers with advertising. This is particularly true in mature markets with many competitors that sell relatively undifferentiated products. However, the authors present findings from a large-scale randomized field experiment that contrast sharply with this prediction. The field experiment measures the impact of competitors' advertising on sales at a private label apparel retailer. Surprisingly, for a substantial segment of customers, the competitors' advertisements increased sales at this retailer. This robust effect was obtained through experimental manipulation and by measuring actual purchases from large samples of randomly assigned customers. The effect size is also large, with customers ordering more than 4% more items in some categories in the treatment condition (vs. the control). The authors examine how these positive spillovers vary across product categories to illustrate the importance of product standards, customer learning, and switching costs. The findings have the potential to change our understanding of competition in mature markets.
Fabella Fractures after Total Knee Arthroplasty with Correction of Valgus Malalignment

The incidence of fabella fractures is considered to be extremely low. This report presents two patients with femorotibial osteoarthritis and considerable preoperative valgus malalignment, who developed a fracture of the fabella (as demonstrated by radiography) after total knee arthroplasty with intraoperative correction of the valgus malalignment. Special attention should be paid to the fabella for not missing a fabella fracture in these patients.
Heat Flow and Hydrothermal Circulation in the Cascade Range, North-Central Oregon

In north-central Oregon a large area of near-zero near-surface conductive heat flow occurs in young volcanic rocks of the Cascade Range. Recent advective heat flux measurements and a heat-budget analysis suggest that ground-water circulation sweeps sufficient heat out of areas where rocks younger than 6 Ma (million years ago) are exposed to account for the anomalously high advective and conductive heat discharge measured in older rocks at lower elevations. Earlier workers have proposed that an extensive midcrustal magmatic heat source is responsible for this anomalously high heat flow. Instead, high heat flow in the older rocks may be a relatively shallow phenomenon caused by regional ground-water flow. Any deeper anomaly may be relatively narrow, spatially variable, and essentially confined to the Quaternary (less than 2 Ma) arc. Magmatic intrusion at a rate of 9 to 33 cubic kilometers per kilometer of arc length per million years can account for the total heat flow anomaly. Deep drilling in the areas of high heat flow in the older rocks could indicate which model is more appropriate for the near-surface heat flow data.
Mindfulness, rumination and post-traumatic growth in a Chinese cancer sample

ABSTRACT A multiple mediation structural equation model was used to test the relationship between mindfulness, deliberate rumination, intrusive rumination and post-traumatic growth (PTG) among Chinese cancer patients. Data were collected from 309 cancer patients in China (61.2% male, 38.8% female), who completed questionnaires comprising the Mindful Attention Awareness Scale, the Event Related Rumination Inventory and the Post-traumatic Growth Inventory. The multiple mediation structural equation model showed that deliberate rumination partially mediated the relationship between mindfulness and PTG. However, the mediatory effect of intrusive rumination was not significant. Our findings indicated that deliberate rumination functions as an essential mechanism in the relationship between mindfulness and PTG. The results showed that interventions to increase mindfulness are needed in order to encourage PTG.
A reference dataset for the analyses of membrane protein secondary structures and transmembrane residues using circular dichroism spectroscopy

MOTIVATION Empirical analyses of protein secondary structures based on circular dichroism (CD) and synchrotron radiation circular dichroism (SRCD) spectroscopic data rely on the availability of reference datasets comprised of spectra of relevant proteins, whose crystal structures have been determined. Datasets comprised of only soluble proteins have not proven suitable for analysing the spectra of membrane proteins. RESULTS A new reference dataset, MP180, has been created containing the spectra of 30 membrane proteins encompassing the secondary structure and fold space covered by all known membrane protein structures. In addition a mixed soluble and membrane protein dataset, SMP180, has been created, which includes 98 soluble protein spectra (SP) plus the MP180 spectra. Calculations of both membrane and soluble protein secondary structures using SMP180 are significantly improved with respect to those produced, using soluble protein-only datasets. The SMP180 dataset also enables determination of the percentage of transmembrane residues, thus enhancing the information previously obtainable from CD spectroscopy. AVAILABILITY AND IMPLEMENTATION Reference dataset online at the DichroWeb analysis server (http://dichroweb.cryst.bbk.ac.uk); individual protein spectra in the Protein Circular Dichroism Data Bank (http://pcddb.cryst.bbk.ac.uk).
Experimental characterization and computational modelling of two-dimensional cell spreading for skeletal regeneration

Limited cell ingrowth is a major problem for tissue engineering and the clinical application of porous biomaterials as bone substitutes. As a first step, migration and proliferation of an interacting cell population can be studied in two-dimensional culture. Mathematical modelling is essential to generalize the results of these experiments and to derive the intrinsic parameters that can be used for predictions. However, a more thorough evaluation of theoretical models is hampered by limited experimental observations. In this study, experiments and image analysis methods were developed to provide a detailed spatial and temporal picture of how cell distributions evolve. These methods were used to quantify the migration and proliferation of skeletal cell types including MG63 and human bone marrow stromal cells (HBMSCs). The high level of detail with which the cell distributions were mapped enabled a precise assessment of the correspondence between experimental results and theoretical model predictions. This analysis revealed that the standard Fisher equation is appropriate for describing the migration behaviour of the HBMSC population, while for the MG63 cells a sharp front model is more appropriate. In combination with experiments, this type of mathematical model will prove useful in predicting cell ingrowth and improving strategies and control of skeletal tissue regeneration.
Depicting the Keypad Mouse Interface: Exploring Pointing Behaviors of Three Input Devices

Using standard keyboard for pointing and clicking interactions seems to be an affordable option for people who have difficulties handling a standard mouse due to a lack of dexterity or temporal disability conditions. The keypad mouse uses discrete input based on keystrokes to perform cursor movements. This distinctive feature along with others related to cursor motion behavior, make the keypad mouse a unique pointing interface when compared with alternatives. We have carried out a study with expert users of different pointing devices. Results of the study revealed significant differences in the performance values among participants in the three groups. Direction on aimed cursor movements proved to be a crucial factor to be taken into account for keyboard-only users. The findings presented in this paper have a broad application when it comes to designing effective predictive models as well as to proposing design guidelines, novel interaction techniques and adaptation techniques for this collective.
Efficacy of Nitric Oxide Fumigation for Controlling Codling Moth in Apples

Nitric oxide (NO) fumigation under ultralow oxygen (ULO) conditions was studied for its efficacy in controlling codling moth and effects on postharvest quality of apples. NO fumigation was effective against eggs and larvae of different sizes on artificial diet in 48 h treatments. Small larvae were more susceptible to nitric oxide than other stages at 0.5% NO concentration. There were no significant differences among life stages at 1.0% to 2.0% NO concentrations. In 24 h treatments of eggs, 3.0% NO fumigation at 2 °C achieved 100% egg mortality. Two 24 h fumigation treatments of infested apples containing medium and large larvae with 3.0% and 5.0% NO resulted in 98% and 100% mortalities respectively. Sound apples were also fumigated with 5.0% NO for 24 h at 2 °C to determine effects on apple quality. The fumigation treatment was terminated by flushing with nitrogen and had no negative impact on postharvest quality of apples as measured by firmness and color at 2 and 4 weeks after fumigation. This study demonstrated that NO fumigation was effective against codling moth and safe to apple quality, and therefore has potential to become a practical alternative to methyl bromide fumigation for control of codling moth in apples.
Assessment of the Induction of Dormant Ring Stages in Plasmodium falciparum Parasites by Artemisone and Artemisone Entrapped in Pheroid Vesicles In Vitro

ABSTRACT The in vitro antimalarial activities of artemisone and artemisone entrapped in Pheroid vesicles were compared, as was their ability to induce dormancy in Plasmodium falciparum. There was no increase in the activity of artemisone entrapped in Pheroid vesicles against multidrug-resistant P. falciparum lines. Artemisone induced the formation of dormant ring stages similar to dihydroartemisinin. Thus, the Pheroid delivery system neither improved the activity of artemisone nor prevented the induction of dormant rings.
Active learning with committees and the selection of starting sets

Obtaining tagged training data takes a long time and also is a costly task. Active learning aims machine learning algorithms achieve reasonable accuracies with less tagged training data. To this purpose, one of the methods for determining which samples to be tagged is making use of the decisions of classifier ensembles. Within this work, we implemented a committee-based active learning application and compared it with non-active methods.
Can Video Technology Improve Teacher Evaluations? An Experimental Study

Teacher evaluation reform has been among the most controversial education reforms in recent years. It also is one of the costliest in terms of the time teachers and principals must spend on classroom observations. We conducted a randomized field trial at four sites to evaluate whether substituting teacher-collected videos for in-person observations could improve the value of teacher observations for teachers, administrators, or students. Relative to teachers in the control group who participated in standard in-person observations, teachers in the video-based treatment group reported that post-observation meetings were more “supportive” and they were more able to identify a specific practice they changed afterward. Treatment principals were able to shift their observation work to noninstructional times. The program also substantially increased teacher retention. Nevertheless, the intervention did not improve students’ academic achievement or self-reported classroom experiences, either in the year of the intervention or for the next cohort of students. Following from the literature on observation and feedback cycles in low-stakes settings, we hypothesize that to improve student outcomes schools may need to pair video feedback with more specific supports for desired changes in practice.
Production and applications of carbohydrate-derived sugar acids as generic biobased chemicals

Abstract This review considers the chemical and biotechnological synthesis of acids that are obtained by direct oxidation of mono- or oligosaccharide, referred to as sugar acids. It focuses on sugar acids which can be readily derived from plant biomass sources and their current and future applications. The three main classes of sugar acids are aldonic, aldaric and uronic acids. Interest in organic acids derived from sugars has recently increased, as part of the interest to develop biorefineries which produce not only biofuels, but also chemicals to replace those currently derived from petroleum. More than half of the most desirable biologically produced platform chemicals are organic acids. Currently, the only sugar acid with high commercial production is d-gluconic acid. However, other sugar acids such as d-glucaric and meso-galactaric acids are being produced at a lower scale. The sugar acids have application as sequestering agents and binders, corrosion inhibitors, biodegradable chelators for pharmaceuticals and pH regulators. There is also considerable interest in the use of these molecules in the production of synthetic polymers, including polyamides, polyesters and hydrogels. Further development of these sugar acids will lead to higher volume production of the appropriate sugar acids and will help support the next generation of biorefineries.