Miracle-dz/UniFAR-FTUs huggingface dataset:
Adaptive Big Data Analytics for Deceptive Review Detection in Online Social Media

The explosive growth of user-contributed reviews in e-Commerce and online social network sites prompts for the design of novel big data analytics frameworks to cope with such a challenge. The main contributions of our research are twofold. First, we design a novel big data analytics framework that leverages distributed computing and streaming to efficiently process big social media data streams. Second, we apply the proposed framework that is underpinned by a novel parallel co-evolution genetic algorithm to adaptively detect deceptive reviews with respect to different social media contexts. Our experiments show that the proposed big data analytics framework can effectively and efficiently detect deceptive reviews from a big social media data stream, and it outperforms other non-distributed big data analytics solutions. To the best of our knowledge, this is the first successful design of an adaptive big data analytics framework for deceptive review detection under a big data environment.
Functional adaptability of muscle fibers to long-term resistance exercise.

PURPOSE We compared the functional properties of muscle fibers from two groups of subjects that differed widely in their training history to investigate whether long-term resistance exercise alters the intrinsic contractile properties of skeletal muscle fibers. METHODS Vastus lateralis muscle biopsies were obtained from six sedentary males (NT group, age = 23 +/- 1 yr) and six males who had participated in regular resistance exercise training over the preceding 7.6 +/- 1.6 yr (RT group, 22 +/- 1 yr). Chemically skinned muscle fiber segments were activated with a saturating free [Ca2+] to quantify fiber peak Ca2+-activated force (P(o)), unloaded shortening velocity (V(o)), and peak power. Fiber segment myosin heavy chain (MHC) isoform content was identified by gel electrophoresis. RESULTS Slow and fast fibers from the RT group were larger in CSA and produced greater absolute P(o) and absolute peak power in comparison with fibers from the NT group. However, these differences were no longer evident after P(o) and peak power were normalized to fiber CSA and fiber volume, respectively. V(o)/fiber length was dependent on fiber MHC content but independent of training status. CONCLUSION Fiber hypertrophy was sufficient to account for intergroup differences in P(o) and peak power of slow and fast fibers. There was no evidence that the intrinsic contractility of slow or fast fibers, as evaluated by force, shortening velocity, and power normalized to the appropriate fiber dimensions, differed between RT and NT groups.
Hypercyclicity and k-Transitivity (k>=2) for abelian semigroup of affine maps on C^n

In this paper, we prove that the minimal number of affine maps on C^n, required to form a hypercyclic abelian semigroup on C^n is n+1. We also prove that the action of any abelian group finitely generated by affine maps on C^n, is never k-transitive for k>=2.
Acoustic Markers Associated with Impairment in Language Processing in Alzheimer's Disease

This study broaches in a novel way the analysis of cognitive impairment characteristic of the early stages of Alzheimer's Disease (AD). Specifically, we attempt to determine the acoustic speech parameters that are sensitive to the onset of the disease, and their association with the language deficit characteristic of AD. Speech analysis was carried out on 21 elderly patients with AD using Praat software, which analyzes the acoustic components of speech. The data obtained were subjected to stepwise regression, using the overall scores obtained in the test as the criterion variable, and the scores on the frequency, amplitude and periodicity variables as predictors of performance. We found that the percentage of voiceless segments explains a significant portion of the variance in the overall scores obtained in the neuropsychological test. This component seems to be related mainly to the patient's ability in phonological fluency. This finding could permit the creation of a diagnostic test for AD through analysis of the acoustic speech parameters at very low cost in terms of both time and resources. El estudio aborda una manera novedosa el análisis de los deterioros cognitivos característicos de las primeras fases de la Enfermedad de Alzheimer (EA). En concreto, se pretende determinar los parámetros acústicos del habla sensibles al inicio de la enfermedad, y su asociación con el déficit lingüístico característico de la EA. Realizamos un análisis del habla a 21 mayores con EA, por medio del software Praat que analiza los componentes acústicos del habla. Los datos obtenidos se analizaron mediante la técnica de regresión paso a paso, con las puntuaciones globales obtenidas en las diferentes pruebas neuropsicológicas como variable criterio, (entre otras el test de Cuetos-Vega de procesamiento lingüístico) y las puntuaciones en las variables de frecuencia, amplitud y periodicidad del sonido como predictores de su ejecución. Obtuvimos que el porcentaje de segmentos sordos explica una parte significativa de la varianza de la puntuación global obtenida en la prueba neuropsicológica. Este componente parece estar relacionado, principalmente, con la capacidad de fluidez fonológica del paciente. Esto podría permitir la elaboración de una prueba de diagnóstico de la EA a través del análisis de los parámetros acústicos del habla con un coste temporal y material muy bajo.
The Influence of Interleukin 17A and IL17F Polymorphisms on Chronic Periodontitis Disease in Brazilian Patients

A case-control study was conducted on patients with chronic periodontitis (CP) and healthy controls with the aim of evaluating possible association between interleukin 17A (IL17A) G197A (rs2275913) and IL17F T7488C (rs763780) polymorphisms and periodontitis. Genotypes were determined by PCR-RFLP method. Statistical analyses were conducted using the OpenEpi and SNPStas software to calculate Chi-square with Yates correction or Fisher's exact tests, odds ratios (OR), and 95% confidence intervals (CIs). SNPStas software was used to calculate Hardy-Weinberg equilibrium. IL17A AA genotype was more frequent in patients with chronic periodontitis (CP) in the codominant and recessive models (P = 0.09; OR = 2.53 and P = 0.03; OR = 2.46, resp.), the females with CP (P = 0.01, OR = 4.34), Caucasoid patients with CP (P = 0.01, OR = 3.45), and nonsmoking Caucasian patients with CP (P = 0.04, OR = 3.51). The IL17A A allele was also more frequent in Caucasians with CP (P = 0.04, OR = 1.59). IL17F T7488C polymorphism was not associated with chronic periodontitis. In these patients from Southern Brazil, the IL17A rs2275913 polymorphisms, IL17A AA genotype, and the A allele were associated with a susceptibility to chronic periodontitis.
14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK

The LKB1 tumour suppressor kinase phosphorylates and activates a number of protein kinases belonging to the AMP-activated protein kinase (AMPK) subfamily. We have used a modified tandem affinity purification strategy to identify proteins that interact with AMPKα, as well as the twelve AMPK-related kinases that are activated by LKB1. The AMPKβ and AMPKγ regulatory subunits were associated with AMPKα, but not with any of the AMPK-related kinases, explaining why AMP does not influence the activity of these enzymes. In addition, we identified novel binding partners that interacted with one or more of the AMPK subfamily enzymes, including fat facets/ubiquitin specific protease-9 (USP9), AAA-ATPase-p97, adenine nucleotide translocase, protein phosphatase 2A holoenzyme and isoforms of the phospho-protein binding adaptor 14-3-3. Interestingly, the 14-3-3 isoforms bound directly to the T-loop Thr residue of QSK and SIK, after these were phosphorylated by LKB1. Consistent with this, the 14-3-3 isoforms failed to interact with non-phosphorylated QSK and SIK, in LKB1 knockout muscle or in HeLa cells in which LKB1 is not expressed. Moreover, mutation of the T-loop Thr phosphorylated by LKB1, prevented QSK and SIK from interacting with 14-3-3 in vitro. Binding of 14-3-3 to QSK and SIK, enhanced catalytic activity towards the TORC2 protein and the AMARA peptide, and was required for the cytoplasmic localization of SIK and for localization of QSK to punctate structures within the cytoplasm. To our knowledge, this study provides the first example of 14-3-3 binding directly to the T-loop of a protein kinase and influencing its catalytic activity and cellular localization.
Pendekatan Problem Based Learning untuk Mengembangkan Kemampuan Berpikir Kritis Mahasiswa

Salah satu upaya meningkatkan kualitas sumber daya perguruan tinggi adalah mengembangkan kemampuan berpikir kritis mahasiswa. Hal ini mendorong peneliti untuk menerapkan pendekatan problem based learning sebagai upaya mengembangkan kemampuan berpikir kritis mahasiswa khususnya mahasiswa Pendidikan Matematika IKIP Budi Utomo Malang pada mata kuliah Geometri. Salah satu keunggulan dari pendekatan problem based learning adalah pendekatan ini berorientasi pada kecakapan siswa memproses informasi. Pemrosesan informasi ini mengacu pada cara siswa berinteraksi dengan lingkungannya, melihat masalah, mengembangkan konsep, dan memecahkan masalah tersebut. Dengan demikian kemampuan berpikir kritis dapat berkembang karena dalam penelitian ini kemampuan berpikir kritis yang diamati mencangkup kemampuan mengidentifikasi masalah, menganalisis masalah, memecahkan masalah, dan menarik kesimpulan dengan tepat.
Children’s felicitous use of intersubjective particles evidences sensitivity to constellations of perspectives

Discourse particles specify how interlocutors’ understandings converge and differ, and appropriate use requires ability to represent propositions from two perspectives simultaneously. This makes discourse particles a highly useful case for investigating developments in children’s ability to monitor and compare mental states, a controversial issue in child language research. Being neither salient, nor obligatory, the particles further allow us to assess children’s motivation to look for interpersonal meanings without strong linguistic incentives. By means of a corpus analysis of peer group conversations (123 hours, 19 children: 1;9–6;3 years), the present study examines at which ages Danish kindergarteners demonstrate stable mastery of the interpersonal contextual demands of five particles marking shared knowledge, disagreement and differential access to knowledge. As background for evaluating children’s particle use as well as order of occurrence, adult consensus on particle meanings was substantiated with a gap-filling test and relative input frequency estimated in caregiver speech. Children were significantly above chance in producing intersubjective particles in felicitous contexts and differentiated clearly between the particles. While there was a strong increase in token frequency over the kindergarten years, children evidenced sensitivity to context from their first productions, and particle felicity did not improve significantly with higher age or production experience. The results suggest that 3-to-6-year-olds routinely monitor and compare representational states, and that they are highly motivated to coordinate conversations as joint actions by pointing to interlocutor perspectives.
Opening up Openness to Experience: An appraisal process approach towards understanding individual differences in epistemic engagement

This thesis offers new insights into the relationship between epistemic engagement and the personality domain of Openness to Experience. In seeking to better understand this relationship, the unique influence of the lower order aspects of Openness and Intellect on engagement was evaluated. Particularly, the proposal that Openness and Intellect represent individual differences in engagement with diverging information is tested—Openness with sensory and perceptual, and Intellect with abstract and semantic. Additionally, a processbased understanding for the differences between the aspects in the context of engagement with information was sought. Such an understanding can shift Openness/Intellect beyond a descriptive construct, and provide explanations for relationships between the domain and epistemic engagement. Four studies evaluated whether Openness and Intellect were differentially related to interest in various informational stimuli—quotations (study 1), visual art (study 2, 3 and 4), philosophy and science (study 4). Throughout the studies, Openness was the consistent predictor of interest in all stimuli. The influence of Openness on engagement was also consistently qualified by appraisal-emotion contingencies. Particularly, Openness was associated with stronger novelty-interest relationships suggesting a reactivity to novel and complex situations. The implications of this finding for the previously observed relationships between Openness, Cognitive Abilities, and Educational outcomes are discussed. The lack of associations between engagement and Intellect is, in part, explained by the measurement of the construct being misaligned with its conceptualisation. Overall, these findings suggest that a clear engagement distinction between Openness and Intellect in terms of stimulus type is premature. Instead, Openness seems to currently represent the affective engagement aspect of the domain, while Intellect is related to greater understanding, but not interest.
Integrated and faith-based schooling in northern Ireland

Issues are explored relating to the diversity of schooling provision in Northern Ireland in the context of the debate around faith-based schooling in England and elsewhere. The benefits to individuals from a religious point of view are off-set against any potential impact on social cohesion. Integrated schools as models for shared education are considered, as are innovative methods of co-management that may emerge in the future. In the context of a fragile society emerging from conflict and yet apparently more polarized than ever, it is argued that choices inevitably have consequences and that the long-term price of separate schooling may be further division.
Elucidation of a Physiological Adjustment Effect in a Forest Environment: A Pilot Study

There is a significant positive relationship between exposure to forest environments and physical and mental health. However, there are individual differences within these responses, and this phenomenon has posed questions in various fields. Here, we show that the physiological effect of a forest environment can differ depending on a subject’s initial values and that forests have a physiological adjustment effect close to an appropriate level. Subjects with high initial blood pressure and pulse rate showed a decrease in these values after walking in a forested area, whereas those with low initial values showed an increase. There was no physiological adjustment effect observed in an urban area; thus, these effects are specific to a forest environment.
Phases in the junior-to-senior transition of Swedish ice hockey players: From a conceptual framework to an empirical model

The purpose of this study was to explore a temporal structure (i.e. sequence of phases and relevant psychological content) of the junior-to-senior transition in Swedish ice hockey players. The study was a qualitative exploration of the junior-to-senior transition process designed in three steps. First, the athletic career transition model coupled with a holistic developmental approach and analysis of the Swedish ice hockey context were used to create a conceptual four-phase (preparation, orientation, adaptation and stabilization) junior-to-senior transition framework and interview guides. Second, seven active semi-professional ice hockey players were interviewed about their junior-to-senior transition experiences and asked for their feedback on the conceptual framework. Finally, based on the empirical data and the participants’ feedback, the conceptual framework was transformed into an empirical model of the junior-to-senior transition. In the empirical model ‘Phases in the junior-to-senior transition of Swedish ice hockey players’, the authors provided a summary of the players’ transition experiences (i.e. perceived demands, resources, barriers, coping strategies and outcomes) within each of the four (i.e. the preparation, the orientation, the adaptation and the stabilization) junior-to-senior transition phases. Further, the authors discussed the empirical model in relation to theoretical frameworks and previous research and also provided methodology-, future research- and practice-oriented reflections addressed to researchers, coaches and sport psychology practitioners.
Quantifying Serum Level of Glycochenodeoxycholic Acid Using High Performance Liquid Chromatography in Obstructive Jaundice Patients

Introduction. Accumulation of glycochenodeoxycholic acid (GCDC) in serum has a clinical significance as an inductor of pathological hepatocyte apoptosis, which impairs liver function. Inhibition of GCDC accumulation can be used as a marker in therapy. This study was aimed to quantify the serum level of GCDC in obstructive jaundice patients. Methodology. GCDC acid level in the serum was quantified using high performance liquid chromatography (HPLC) technique according to Muraca and Ghoos modified method. It was performed before and after decompression at day 7 and day 14. The sample was extracted with solid phase extraction (SPE) technique on SPE column. The results were analyzed using SPSS V 16.0 (P < 0.05) and quantified with standard curve on GCDC acid. Result. There were 21 cases with range of GCDC acid serum level before decompression was 90.9 (SD 205.5) μmol/L and day 7 after decompression decreased to 4.0 (SD 46.4) μmol/L and then increased to 11.3 (SD 21.9) μmol/L (P < 0.05). This method could separate GCDC acid on serum with good resolution, high precision and accuracy, and linear calibration curve on measured level range. Conclusion. HPLC can quantify GCDC acid serum on obstructive jaundice patients and can be used to support its pharmacokinetic study.
Social presence, facial feedback, and emotion.

This study examined the influence of facial feedback on emotional experience and the influence of another's presence on facial communication. To test whether facial expressions regulate the expressers' emotional experience, subjects smelled pleasant and disgusting odors while reacting to them spontaneously, with a facial pose indicating that the odors were pleasant or with a facial pose indicating that they were disgusting. In a result that supported the facial feedback hypothesis, subjects evaluated the odors consistently with their facial poses (p < .001). But the odors themselves had a far greater impact on evaluations than did posing instructions. To test whether both spontaneous and deceptive emotional expressions would be more effective as communication if the expresser were in the presence of another, rather than alone, subjects smelled odors when they were alone or when seated next to another naive subject who could not see them. Contrary to prediction, subjects were less successful facial communicators in the presence of another. In this condition they communicated their evaluations less when they were spontaneously reacting to the odors and leaked their evaluations more when they were trying to hide their expressions (p < .07).
Effects of supine and inverted seated positions on neuromuscular and cardiovascular parameters

Purpose: The inverted and supine body positions are not common postures humans adopt. During unusual situations (e.g. overturned helicopters, motor vehicle accidents, gymnastics) when body position is altered, neuromuscular and cardiovascular (CV) responses can change. To optimally manage these situations, it is necessary to examine the changes in muscle force output, activation and CV parameters. In previous research, impairments during posture change were believed to be secondary to inhibition of sympathetic nervous system activity in recreational subjects. The purpose of this research was to evaluate the neuromuscular and CV changes in supine and inverted body positions on a group of aerobically trained athletes before and following physical fatigue. Methods: Twelve male athletes completed three trials in the upright, supine and inverted seated positions. At baseline (upright), leg extension (LE) and elbow flexion (EF) evoked contractile properties and MVCs were performed. The participant was then positioned for 150s in each posture, followed by a 30s MVC (MVC30). During each trial, stroke volume (SV), cardiac output (Q), heart rate (HR), time and frequency domain HR variability measures and mean arterial blood pressure (MAP) measurements were recorded. As well, force-fatigue and EMG relationships were evaluated. Results: An ANOVA showed no statistical differences in EF MVC force, but a tendency (p=0.12) for LE MVC decline across positions with moderate effect size. EF evoked resting twitch (p=0.1) had a decline in force that was not significant from upright to inverted and no change from upright to supine. Potentiated peak twitch (p=0.06) force displayed a tendency towards an increase from upright to supine and decline in force from upright to inverted postures (p=0.1). LE evoked resting twitch had a non-significant (p=0.1) but large magnitude increase in force across the three positions and there was a significant increase in potentiated twitch force (p=0.03). Force-fatigue, electromyography-fatigue relationships and HR variability during MVC30 fatigue across positions were not affected. HR and Q were significantly (p<0.01) lower with inversion following both LE and EF fatigue. Conclusions: The lack of significant postural changes in resting force and CV measures may demonstrate that highly trained individuals may adapt better to the supine and inverted positions.
A Clostridium difficile Cell Wall Glycopolymer Locus Influences Bacterial Shape, Polysaccharide Production and Virulence

Clostridium difficile is a diarrheagenic pathogen associated with significant mortality and morbidity. While its glucosylating toxins are primary virulence determinants, there is increasing appreciation of important roles for non-toxin factors in C. difficile pathogenesis. Cell wall glycopolymers (CWGs) influence the virulence of various pathogens. Five C. difficile CWGs, including PSII, have been structurally characterized, but their biosynthesis and significance in C. difficile infection is unknown. We explored the contribution of a conserved CWG locus to C. difficile cell-surface integrity and virulence. Attempts at disrupting multiple genes in the locus, including one encoding a predicted CWG exporter mviN, were unsuccessful, suggesting essentiality of the respective gene products. However, antisense RNA-mediated mviN downregulation resulted in slight morphology defects, retarded growth, and decreased surface PSII deposition. Two other genes, lcpA and lcpB, with putative roles in CWG anchoring, could be disrupted by insertional inactivation. lcpA - and lcpB - mutants had distinct phenotypes, implying non-redundant roles for the respective proteins. The lcpB - mutant was defective in surface PSII deposition and shedding, and exhibited a remodeled cell surface characterized by elongated and helical morphology, aberrantly-localized cell septae, and an altered surface-anchored protein profile. Both lcpA - and lcpB - strains also displayed heightened virulence in a hamster model of C. difficile disease. We propose that gene products of the C. difficile CWG locus are essential, that they direct the production/assembly of key antigenic surface polysaccharides, and thereby have complex roles in virulence.