Miracle-dz/UniFAR-FTUs huggingface dataset:
Discrepancies between energy intake and expenditure in physically active women

Energy intake and expenditure in women runners and non-runners were assessed by weighed food records, evaluation of minute-by-minute activity diaries, and indirect calorimetry. All participants were adapted to their stated activity levels for at least 6 months and maintained a constant body-weight throughout their participation. Calculated daily energy intake equalled calculated expenditure in non-runners (7300 (SD 1536) v. 7476 (SD 872) kJ/d), but calculated energy expenditure in women running about 54 km/week was found to exceed intake by more than 2700 kJ/d (8259 (SD 1466) v. 10963 (SD 1367), P < 0.01). The runners showed no evidence of compensating for the increased energy expenditure associated with running by engaging in lower-intensity activities during non-running time. Further, runners did not decrease energy expended at various activities. The findings suggest that women adapted to high levels of activity may possess mechanisms to maintain body-weight without significantly increasing energy intake.
Non‐bronchodilating mechanisms of tiotropium prevent airway hyperreactivity in a guinea‐pig model of allergic asthma

BACKGROUND AND PURPOSE Asthma is characterized by reversible bronchoconstriction and airway hyperreactivity. Although M3 muscarinic receptors mediate bronchoconstriction, non‐selective muscarinic receptor antagonists are not currently recommended for chronic control of asthma. We tested whether selective blockade of M3 receptors, at the time of antigen challenge, blocks subsequent development of airway hyperreactivity in antigen‐challenged guinea‐pigs.
Diphtheria vaccine: WHO position paper – August 2017.

Introduction In accordance with its mandate to provide guidance to Member States on health policy matters, WHO issues a series of regularly updated position papers on vaccines and combinations of vaccines against diseases that have an international public health impact. These papers are concerned primarily with the use of vaccines in large-scale immunization programmes. They summarize essential background information on diseases and vaccines and conclude with the current WHO position on the use of vaccines worldwide.
Registered Nurses’ Experiences of Priorities in Surgery Care

Priorities and allocation are complex tasks in health care. Unspoken and also often unconscious priorities frequently occur. Research concerning how registered nurses (RN) priorities are limited. The aim of this study was to illuminate the meanings of RNs’ lived experiences of priorities in surgery care. Narrative interviews were conducted with 10 RNs working in a department of surgery. The RNs interviewed had all worked for more than 5 years as RNs. A phenomenological-hermeneutic interpretation of the interviews was conducted. The findings revealed 3 themes: making a conscious allocation and priorities of care, doing unreflected good, and being qualified to determine. The RNs did not often comprehend their actions as prioritizing. They more often comprehended their nursing tasks as obvious and did not consider this as priorities. But in situations of ethical difficulty, the RNs reflected upon their priority and actions.
Genome-Wide Patterns of Nucleotide Polymorphism in Domesticated Rice

Domesticated Asian rice (Oryza sativa) is one of the oldest domesticated crop species in the world, having fed more people than any other plant in human history. We report the patterns of DNA sequence variation in rice and its wild ancestor, O. rufipogon, across 111 randomly chosen gene fragments, and use these to infer the evolutionary dynamics that led to the origins of rice. There is a genome-wide excess of high-frequency derived single nucleotide polymorphisms (SNPs) in O. sativa varieties, a pattern that has not been reported for other crop species. We developed several alternative models to explain contemporary patterns of polymorphisms in rice, including a (i) selectively neutral population bottleneck model, (ii) bottleneck plus migration model, (iii) multiple selective sweeps model, and (iv) bottleneck plus selective sweeps model. We find that a simple bottleneck model, which has been the dominant demographic model for domesticated species, cannot explain the derived nucleotide polymorphism site frequency spectrum in rice. Instead, a bottleneck model that incorporates selective sweeps, or a more complex demographic model that includes subdivision and gene flow, are more plausible explanations for patterns of variation in domesticated rice varieties. If selective sweeps are indeed the explanation for the observed nucleotide data of domesticated rice, it suggests that strong selection can leave its imprint on genome-wide polymorphism patterns, contrary to expectations that selection results only in a local signature of variation.
A Validation of a Measurement Based E-Government Portals' Maturity Model

An e-government portal's maturity model is a set of stages (from basic to advanced ones) that determines the maturity of e-government portals. In fact, these models can be used to provide directions and recommendations for agencies to improve their portals' maturity. However, before choosing a maturity model by any agency, it is important to know to which extent the e-government community agree or disagree with the model. In previous research studies, we have built an e-government portals' maturity model that is based on a best practice model. The aim of this paper is to validate this new model by e-government experts using a survey to prove that the model is valid and reliable. For this purpose, we have described the components of this model, and the previous work that has been done to build it. Based on the results of the survey, our findings show that the new model has proven its validity.
KNAT1 and ERECTA Regulate Inflorescence Architecture in Arabidopsis

Plant architecture is dictated by morphogenetic factors that specify the number and symmetry of lateral organs as well as their positions relative to the primary axis. Mutants defective in the patterning of leaves and floral organs have provided new insights on the signaling pathways involved, but there is comparatively little information regarding aspects of the patterning of stems, which play a dominant role in architecture. To this end, we have characterized five alleles of the brevipedicellus mutant of Arabidopsis, which exhibits reduced internode and pedicel lengths, bends at nodes, and downward-oriented flowers and siliques. Bends in stems correlate with a loss of chlorenchyma tissue at the node adjacent to lateral organs and in the abaxial regions of pedicels. A stripe of achlorophyllous tissue extends basipetally from each node and is positioned over the vasculature that services the corresponding lateral organ. Map-based cloning and complementation studies revealed that a null mutation in the KNAT1 homeobox gene is responsible for these pleiotropic phenotypes. Our observation that wild-type Arabidopsis plants also downregulate chlorenchyma development adjacent to lateral organs leads us to propose that KNAT1 and ERECTA are required to restrict the action of an asymmetrically localized, vasculature-associated chlorenchyma repressor at the nodes. Our data indicate that it is feasible to alter the architecture of ornamental and crop plants by manipulating these genetically defined pathways.
Apamin-Sensitive Potassium Current Modulates Action Potential Duration Restitution and Arrhythmogenesis of Failing Rabbit Ventricles

Background—Apamin-sensitive K currents (IKAS) are upregulated in heart failure. We hypothesize that apamin can flatten action potential duration restitution (APDR) curve and can reduce ventricular fibrillation duration in failing ventricles. Methods and Results—We simultaneously mapped membrane potential and intracellular Ca (Cai) in 7 rabbit hearts with pacing-induced heart failure and in 7 normal hearts. A dynamic pacing protocol was used to determine APDR at baseline and after apamin (100 nmol/L) infusion. Apamin did not change APD80 in normal ventricles, but prolonged APD80 in failing ventricles at either long (≥300 ms) or short (⩽170 ms) pacing cycle length, but not at intermediate pacing cycle length. The maximal slope of APDR curve was 2.03 (95% confidence interval, 1.73–2.32) in failing ventricles and 1.26 (95% confidence interval, 1.13–1.40) in normal ventricles at baseline (P=0.002). After apamin administration, the maximal slope of APDR in failing ventricles decreased to 1.43 (95% confidence interval, 1.01–1.84; P=0.018), whereas no significant changes were observed in normal ventricles. During ventricular fibrillation in failing ventricles, the number of phase singularities (baseline versus apamin, 4.0 versus 2.5), dominant frequency (13.0 versus 10.0 Hz), and ventricular fibrillation duration (160 versus 80 s) were all significantly (P<0.05) decreased by apamin. Conclusions—Apamin prolongs APD at long and short, but not at intermediate pacing cycle length in failing ventricles. IKAS upregulation may be antiarrhythmic by preserving the repolarization reserve at slow heart rate, but is proarrhythmic by steepening the slope of APDR curve, which promotes the generation and maintenance of ventricular fibrillation.
NeuroTrainer: An Intelligent Memory Module for Deep Learning Training

This paper presents, NeuroTrainer, an intelligent memory module with in-memory accelerators that forms the building block of a scalable architecture for energy efficient training for deep neural networks. The proposed architecture is based on integration of a homogeneous computing substrate composed of multiple processing engines in the logic layer of a 3D memory module. NeuroTrainer utilizes a programmable data flow based execution model to optimize memory mapping and data re-use during different phases of training operation. A programming model and supporting architecture utilizes the flexible data flow to efficiently accelerate training of various types of DNNs. The cycle level simulation and synthesized design in 15nm FinFET showspower efficiency of 500 GFLOPS/W, and almost similar throughput for a wide range of DNNs including convolutional, recurrent, multi-layer-perceptron, and mixed (CNN+RNN) networks
Health and Quality of Life Outcomes

Background: The Age-related Macular Degeneration Alliance International commissioned a review of the literature on quality of life (QoL) in macular degeneration (MD) with a view to increasing awareness of MD, reducing its impact and improving services for people with MD worldwide. Method: A systematic review was conducted using electronic databases, conference proceedings and key journal hand search checks. The resulting 'White Paper' was posted on the AMD Alliance website and is reproduced here. Review: MD is a chronic, largely untreatable eye condition which leads to loss of central vision needed for tasks such as reading, watching TV, driving, recognising faces. It is the most common cause of blindness in the Western world. Shock of diagnosis, coupled with lack of information and support are a common experience. Incidence of depression is twice that found in the communitydwelling elderly, fuelled by functional decline and loss of leisure activities. Some people feel suicidal. MD threatens independence, especially when comorbidity exacerbates functional limitations. Rehabilitation, including low vision aid (LVA) provision and training, peer support and education, can improve functional and psychological outcomes but many people do not receive services likely to benefit them. Medical treatments, suitable for only a small minority of people with MD, can improve vision but most limit progress of MD, at least for a time, rather than cure. The White Paper considers difficulties associated with inappropriate use of health status measures and misinterpretation of utility values as QoL measures: evidence suggests they have poor validity in MD. Conclusion: There is considerable evidence for the major damage done to QoL by MD which is underestimated by health status and utility measures. Medical treatments are limited to a small proportion of people. However, much can be done to improve QoL by early diagnosis of MD with good communication of prognosis and continuing support. Support could include provision of LVAs, peer support, education and effective help in adjusting to MD. It is vital that appropriate measures of visual function and QoL be used in building a sound evidence base for the effectiveness of rehabilitation and treatment. Published: 21 December 2006 Health and Quality of Life Outcomes 2006, 4:97 doi:10.1186/1477-7525-4-97 Received: 13 December 2006 Accepted: 21 December 2006 This article is available from: http://www.hqlo. com/content/4/1/97 © 2006 Mitchell and Bradley; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Factors Associated with Early Deterioration after Spontaneous Intracerebral Hemorrhage: A Systematic Review and Meta-Analysis

Background and Purpose Spontaneous intracerebral hemorrhage (ICH) is a devastating form of stroke with a poor prognosis overall. We conducted a systematic review and meta-analysis to identify and describe factors associated with early neurologic deterioration (END) after ICH. Methods We sought to identify any factor which could be prognostic in the absence of an intervention. The Cochrane Library, EMBASE, the Global Health Library, and PubMed were searched for primary studies from the years 1966 to 2012 with no restrictions on language or study design. Studies of patients who received a surgical intervention or specific experimental therapies were excluded. END was defined as death, or worsening on a reliable outcome scale within seven days after onset. Results 7,172 abstracts were reviewed, 1,579 full-text papers were obtained and screened. 14 studies were identified; including 2088 patients. Indices of ICH severity such as ICH volume (univariate combined OR per ml:1.37, 95%CI: 1.12–1.68), presence of intraventricular hemorrhage (2.95, 95%CI: 1.57–5.55), glucose concentration (per mmol/l: 2.14, 95%CI: 1.03–4.47), fibrinogen concentration (per g/l: 1.83, 95%CI: 1.03–3.25), and d-dimer concentration at hospital admission (per mg/l: 4.19, 95%CI: 1.88–9.34) were significantly associated with END after random-effects analyses. Whereas commonly described risk factors for ICH progression such as blood pressure, history of hypertension, and ICH growth were not. Conclusions This study summarizes the evidence to date on early ICH prognosis and highlights that the amount and distribution of the initial bleed at hospital admission may be the most important factors to consider when predicting early clinical outcomes.
Parsing with Generative Models of Predicate-Argument Structure

The model used by the CCG parser of Hockenmaier and Steedman (2002b) would fail to capture the correct bilexical dependencies in a language with freer word order, such as Dutch. This paper argues that probabilistic parsers should therefore model the dependencies in the predicate-argument structure, as in the model of Clark et al. (2002), and defines a generative model for CCG derivations that captures these dependencies, including bounded and unbounded long-range dependencies.
Proteomic similarities in steroid responsiveness in normal and glaucomatous trabecular meshwork cells

Purpose Glucocorticoids (GCs) are common anti-inflammatory agents that can cause ocular hypertension and secondary glaucoma as a consequence of impaired aqueous humor outflow through the trabecular meshwork (TM). Mechanisms of GC-signaling are complex and poorly understood. To better understand GC-signaling in the eye, we tested the hypothesis that common mechanisms of steroid responsiveness exist in TM cells from normal and glaucomatous donors. Methods Four primary cultures of human TM cells from normal and glaucomatous donors were treated with or without dexamethasone (Dex) for 10 days, then cellular proteins were extracted, identified and quantified by liquid chromatography tandem mass spectrometry (LC MS/MS) iTRAQ (isobaric tags for relative and absolute quantitation) technology. Results A total of 718 proteins were quantified. Dex-treatment significantly altered the abundance of 40 proteins in ≥3 cell samples, 37 of which have not previously been associated with GC-signaling in TM cells. Most steroid responsive proteins were changed in all four TM cells analyzed, both normal and glaucomatous. GC-induced proteomic changes support remodeling of the extracellular matrix, disorganization of the cytoskeleton/cell-cell interactions, and mitochondrial dysfunction. Such physiologic consequences appear common to those induced in TM cells by transforming growth factor-β2, another putative contributor to ocular hypertension and glaucoma pathology. Conclusions The results expand the repertoire of TM proteins involved in GC-signaling, demonstrate common consequences of GC-signaling in normal and glaucomatous TM cells, and reveal similarities in proteomic changes induced by steroids and TGFβ2 in normal and glaucomatous TM cells. Finally, the data contributes to a TM quantitative proteomic database.
Health Behaviors of Employed and Insured Adults in the United States, 2004-2005

Purpose. To examine the prevalence of health behaviors, including clinical preventive services and lifestyle risk behaviors, among insured workers and to determine whether disparities in health behaviors based on demographic factors exist among this group. Design. Cross-sectional analysis of 2004–2005 Behavioral Risk Factor Surveillance System data. Setting. United States. Subjects. A representative sample of noninstitutionalized employed and insured adults aged 18 to 64 years (139,738 in 2004 and 159,755 in 2005). Measures. Self-reported clinical preventive services utilization and lifestyle-related behaviors, as well as multiple logistic regression analyses assessing the independent effects of demographic and access variables on health behaviors. Results. Among insured workers, rates of not using recommended clinical preventive services ranged from 8.5% (cervical cancer screening) to 73.9% (influenza vaccination). Rates for engaging in lifestyle-related risks ranged from 5.5% (heavy drinking) to 77.1% (inadequate fruit-vegetable consumption). In multivariate analyses, lower income, lower education, cost as a barrier to health care, and no health care provider were associated with significantly decreased clinical preventive services utilization (p < .01). Lower education and no health care provider were associated with lifestyle-related risks (p < .01). Conclusions. Working insured adults are not meeting recommendations for health behaviors. Significant disparities in health behaviors related to socioeconomic status exist among this group. Employers and insurers should consider these poor health behaviors and disparities when designing insurance benefits addressing clinical preventive services utilization and workplace health promotion programs addressing lifestyle-related behaviors.
Slow Freezing, but Not Vitrification Supports Complete Spermatogenesis in Cryopreserved, Neonatal Sheep Testicular Xenografts

The ability to spur growth of early stage gametic cells recovered from neonates could lead to significant advances in rescuing the genomes of rare genotypes or endangered species that die unexpectedly. The purpose of this study was to determine, for the first time, the ability of two substantially different cryopreservation approaches, slow freezing versus vitrification, to preserve testicular tissue of the neonatal sheep and subsequently allow initiation of spermatogenesis post-xenografting. Testis tissue from four lambs (3-5 wk old) was processed and then untreated or subjected to slow freezing or vitrification. Tissue pieces (fresh, n = 214; slow freezing, then thawing, n = 196; vitrification, then warming, n = 139) were placed subcutaneously under the dorsal skin of SCID mice and then grafts recovered and evaluated 17 wk later. Grafts from fresh and slow frozen tissue contained the most advanced stages of spermatogenesis, including normal tubule architecture with elongating spermatids in ~1% (fresh) and ~10% (slow frozen) of tubules. Fewer than 2% of seminiferous tubules advanced to the primary spermatocyte stage in xenografts derived from vitrified tissue. Results demonstrate that slow freezing of neonatal lamb testes was far superior to vitrification in preserving cellular integrity and function after xenografting, including allowing ~10% of tubules to retain the capacity to resume spermatogenesis and yield mature spermatozoa. Although a first for any ruminant species, findings also illustrate the importance of preemptive studies that examine cryo-sensitivity of testicular tissue before attempting this type of male fertility preservation on a large scale.
The mechanical behavior of poly(lactic acid) unreinforced and nanocomposite films subjected to monotonic and fatigue loading conditions

The mechanical and fatigue behavior of neat poly(lactic acid) (PLA) films and PLA films reinforced with 5 wt% nanoclay particles has been examined using various analytical procedures. The results showed that for the films tested in this study, PLA-5 wt% samples were more susceptible to crazing at the same maximum fatigue stress as the neat PLA samples, as evidenced by results from light transmission experiments. Optical microscopy results confirmed this observation. In addition, under fatigue loading conditions, the neat PLA samples displayed almost the same fatigue resistance (number of cycles to failure) at 3 and 30 Hz, while the PLA-5 wt% samples showed a shift in the number of cycles to failure to higher values at a frequency of 30 Hz. Using the linear regression curves from the S–N data (stress vs. number of cycles to failure), time-to-failure curves were generated to show the difference between the neat PLA and PLA-5 wt% samples when tested at frequencies of 3 and 30 Hz. Based on these results, it is known that the nanoclay particles served to increase the fatigue resistance at the higher frequency of 30 Hz, when compared to the neat PLA sample.
P1-266 Relationship of tooth loss to mild memory impairment and cognitive impairment: findings from the Fujiwara-Kyo study

Introduction This cross-sectional study investigated the relationship between the number of remaining teeth to mild memory impairment (MMI), which is a preclinical stage of dementia, and to cognitive impairment. Methods The subjects were aged 65 years or older and were grouped according to their score for the Mini-Mental State Examination (MMSE), the three-word delayed recall test in the MMSE, and the Geriatric Depression Scale into the control group (n=3696), the MMI group (n=121), and the low MMSE score (23 or lower) group (n=214). We collected data on the number of remaining teeth, the length of the edentulous period, health-related lifestyle, medical history, blood pressure, height, and body weight. Fasting venous blood samples were also obtained. Results Multiple logistic regression analysis, adjusted for depressive symptoms, age, sex, length of education, and other explanatory variables, revealed that the ORs of 0–10 remaining teeth to 22–32 remaining teeth were 1.679 (95% CI 1.073 to 2.627) for MMI and 2.177 (95% CI 1.510 to 3.140) for a low MMSE score. A significant relationship was also found between the length of the edentulous period and the risk of a low MMSE score (OR 3.102, 95% CI 1.432 to 6.720) (15 years or more/<15 years). Conclusions Our findings suggest that tooth loss is associated with low cognitive function. This possible pathophysiology may be presumed by periodontal disease, gene polymorphisms in inflammatory cytokines, and a decrease in the number of periodontal mechanoreceptors.