Miracle-dz/UniFAR-FTUs huggingface dataset:
AEG-1 expression correlates with CD133 and PPP6c levels in human glioma tissues

Abstract Astrocyte elevated gene-1 (AEG-1) is associated with tumor genesis and progression in a variety of human cancers. This study aimed to explore the significance of AEG-1 in glioma and investigate whether it correlated with radioresistance of glioma cells. Immunohistochemical staining showed that the intensity of AEG-1, CD133 and PPP6c protein expression in glioma tissues increased significantly, mainly in the cytoplasm. The expression rate of AEG-1, CD133 and PPP6c were 85.9% (67/78), 60.3% (47/78) and 65.8% (51/78), respectively. AEG-1 expression was correlated with age (r = 0.227, P = 0.045), clinical stage (r = 0.491, P<0.001) and clinical grade (r = 0.450, P<0.001). No correlation was found between AEG-1 expression and other clinicopathologic parameters (P>0.05). The expression of AEG-1 was positively correlated with the expression of CD133 (r = 0.240, P = 0.035) and PPP6c (r = 0.250, P = 0.027). In addition, retrieved data on TCGA implied co-occurrence of genomic alterations of AEG-1 and PPP6c in glioblastoma. Our findings indicate that AEG-1 is positively correlated with CD133 and AEG-1 expression. It may play an important role in the progression of glioma and may serve as potential novel marker of chemoresistance and radioresistance.
Minimum Quantity Lubricant Flow Analysis In End Milling Processes: A Computational Fluid Dynamics Approach

This paper presents a two-dimensional steady-state incompressible analysis for the minimum quantity of lubricant flow in milling operations using a computational fluid dynamics (CFD) approach. The analysis of flow and heat transfer in a four-teeth milling cutter operation was undertaken. The domain of the rotating cutter along with the spray nozzle is defined. Operating cutting and boundary conditions are taken from the literature. A steady-state, pressure-based, planar analysis was performed with a viscous, realizable k-e model. A mixture of oils and air were sprayed on the tool, which is considered to be rotating and is at a temperature near the melting temperature of the workpiece. Flow fields are obtained from the study. The vector plot of the flow field shows that the flow is not evenly distributed over the cutter surface, as well as the uneven distribution of the lubricant in the direction of the cutter rotation. It can be seen that the cutting fluid has not completely penetrated the tool edges. The turbulence created by the cutter rotation in the proximity of the tool throws oil drops out of the cutting zone. The nozzle position in relation to the feed direction is very important in order to obtain the optimum effect of the MQL flow.
Investigating media artifacts with children: Conceptualizing a collaborative exploration of the sociomaterial conduct of everyday life

290 Subject-scientific co-research as theoretical-methodological starting point and challenge . 290 Questioning and specifying analytical concepts so as to foster practical change . 291 Shared struggles in the conduct of everyday life as analytical focus . 291 Media artifacts as two-sided sociomaterial arrangements . 292 Collaboratively arranging sociomaterial learning practices . 292 Resumé . 293 Subjektvidenskabelig medforskning som teoretisk-metodologisk udgangspunkt og udfordring . 293 At udfordre, udvikle og præcisere analytiske begreber, der kan transformere praksis. 294 Fælles konflikter i den daglige livsførelse som analytisk fokus . 294 Medieartefakter som tosidede sociomaterielle arrangementer . 295 Samarbejde om organisering af sociomaterielle læreprocesser . 295
Reviewing and Theorizing the Unintended Consequences of Performance Management Systems

Different design choices in the controls used to manage performance often lead to a range of unintended consequences, which have profound effects on individuals and organizations. This paper presents a mixed review (both systematic and eclectic) of the literature on the unintended consequences of performance management systems, and develops a typology to explain how and why they occur. It finds that the most salient unintended consequences of directive performance management systems are gaming, information manipulation, selective attention, illusion of control and relationships transformation. It argues that these consequences exist as a result of limiting factors such as ignorance, error, short‐term concerns, fundamental values, self‐fulfilling forecasts and changes in social relationships. The emerging typology‐based theory suggests that the choice of control mechanisms is based on two key assumptions concerning goal‐alignment and goal‐uncertainty that relate back to ideas in agency theory and stewardship theory. It concludes that, in the design of performance management systems, the more the ‘assumed’ reality about the state of goal‐alignment and goal‐uncertainty diverges from the ‘real’ state of affairs, the more the resultant system is likely to create perverse unintended consequences, leading to poor organizational outcomes.
Institute of Physics Publishing Journal of Micromechanics and Microengineering Mechanical Domain Coupled Mode Parametric Resonance and Amplification in a Torsional Mode Micro Electro Mechanical Oscillator

In this paper, we experimentally demonstrate non-degenerate parametric resonance in a torsional micro electro mechanical (MEM) oscillator with two interacting mechanical modes of oscillation. The parametric oscillation results from a displacement-dependent electrostatic force generated in both the modes of oscillation. There is a decoupling of the input and the output frequencies in this mode of operation where the system responds at the primary natural frequency when driven at the sum of the first two mechanical modes. This can be implemented in many commonly used MEM oscillator configurations including the cantilever beam geometry. In this mode of operation, single oscillator non-degenerate parametric amplifiers as well as resonant mode sensors based on the frequency selectivity of parametric resonance can be implemented.
Whole-Genome Expression Analysis in the Third Instar Larval Midgut of Drosophila melanogaster

Survival of insects on a substrate containing toxic substances such as plant secondary metabolites or insecticides is dependent on the metabolism or excretion of those xenobiotics. The primary sites of xenobiotic metabolism are the midgut, Malpighian tubules, and fat body. In general, gene expression in these organs is reported for the entire tissue by online databases, but several studies have shown that gene expression within the midgut is compartmentalized. Here, RNA sequencing is used to investigate whole-genome expression in subsections of third instar larval midguts of Drosophila melanogaster. The data support functional diversification in subsections of the midgut. Analysis of the expression of gene families that are implicated in the metabolism of xenobiotics suggests that metabolism may not be uniform along the midgut. These data provide a starting point for investigating gene expression and xenobiotic metabolism and other functions of the larval midgut.
Send Orders of Reprints at Reprints@benthamscience.org Procedural Knowledge, Decision Making and Performance in Women's Volleyball According to Age Group and Specific Experience

The purpose of this study was to analyze the procedural knowledge in action, decision-making and performance of the left-side attacker according to age group and specific experience, in women's volleyball. Four Portuguese women's teams participated in the present study: one under-16, one under-18 and two adult teams. A verbal interview protocol was implemented immediately after randomly chosen live game actions. The left-side attackers had to verbally respond to this question immediately following the execution of an attack, in 6 vs. 6 situations in practice. Players' decision-making and performance were analyzed by video images. Procedural knowledge was analyzed trough non-parametric statistics, namely Kruskal-Wallis and Mann-Whitney tests. Decision-making and performance were analyzed through Chi-square (! 2) testing. Results showed that adult teams and the more experienced left-side attackers generated more goal concepts and fewer condition concepts, were more often concerned with the opponent and less with teammates. Moreover, no differences in player's performance and decision-making were observed according to age group and experience as left-side attackers. Further research should consider the characterization of the training process, mainly focusing on the tactical contents, as the information provided could provide a better and deeper understanding about the players' tactical development.
Association of mitogen-activated protein kinases with microtubules in mouse macrophages

Taxol, a microtubule-binding diterpene, mimics many effects of lipopolysaccharide (LPS) on mouse macrophages. The LPS-mimetic effects of taxol appear to be under the same genetic control as responses to LPS itself. Thus we have postulated a role for microtubule-associated proteins (MAP) in the response of macrophages to LPS. Stimulation of macrophages by LPS quickly induces the activation of mitogen-activated protein kinases (MAPK). MAPK are generally considered cytosolic enzymes. Herein we report that much of the LPS-activatable pool of MAPK in primary mouse peritoneal macrophages is microtubule associated. By immunofluorescence, MAPK were localized to colchicine- and nocodazole- disruptible filaments. From both mouse brain and RAW 264.7 macrophages, MAPK could be coisolated with polymerized tubulin. Fractionation of primary macrophages into cytosol-, microfilament-, microtubule-, and intermediated filament-rich extracts revealed that approximately 10% of MAPK but none of MAPK kinase (MEK1A and MEK2) was microtubule bound. Exposure of macrophages to LPS did not change the proportion of MAPK bound to microtubules, but preferentially activated the microtubule- associated pool. These findings confirm the prediction that LPS activates a kinase bound to microtubules. Together with LPS-mimetic actions of taxol and the shared genetic control of responses to LPS and taxol, these results support the hypothesis that a major LPS-signaling pathway in mouse macrophages may involve activation of one or more microtubule-associated kinases.
Transposon characterization of vancomycin-resistant Enterococcus faecium (VREF) and dissemination of resistance associated with transferable plasmids.

OBJECTIVES VanA glycopeptide resistance has persisted on broiler farms in the UK despite the absence of the antimicrobial selective pressure, avoparcin. This study aimed to investigate the contribution of horizontal gene transfer of Tn1546 versus clonal spread in the dissemination of the resistance. METHODS AND RESULTS One hundred and one vancomycin-resistant Enterococcus faecium isolated from 19 unrelated farms have been investigated. Tn1546 characterization by long PCR and ClaI-digestions of amplicons showed a very low diversity of Tn types (n=4) in comparison to the high genotypic diversity demonstrated by PFGE (n=62). Conjugation experiments were carried out to assess the transfer of vancomycin resistance. Co-transfer of vanA together with erm(B) positioned on the same conjugative plasmid containing a replicon similar to pRE25 was demonstrated and also the presence of different plasmid replicons, associated with antimicrobial resistance on several unrelated farms. CONCLUSIONS Horizontal transfer of vancomycin resistance may play a more important role in the persistence of antimicrobial resistance than clonal spread. The presence of different plasmid replicons, associated with antimicrobial resistance on several unrelated farms, illustrates the ability of these enterococci to acquire and disseminate mobile genetic elements within integrated livestock systems.
Romantic Relationship Decisions: Focusing on the Role of the Partner

Decisions about romantic relationships impact a romantic partner as well as the self. In the present research, I tested whether people can be motivated to make relationship decisions that are not necessarily in their own best interests for the sake of the partner. Studies 1 and 2 examined commitment choices. I found that being randomly assigned to write about previous investments the partner had made into the relationship (e.g., time, energy, material resources) led people to feel more committed to their relationships (Study 1). Further, greater daily investment from the partner predicted increases in own commitment over time, even for people who were relatively dissatisfied with their relationships (Study 2). These effects in Studies 1 and 2 were partly explained by the fact that the partner’s investments elicited feelings of gratitude. I next examined breakup decisions in Study 3 by following 1348 individuals in relationships over a 10-week period. I found that people who believed that a breakup would greatly distress their romantic partner were less likely to break up with their partner over the course of the study. This effect held controlling for many previously identified predictors of breakups (e.g., own commitment, own investment), and extended even to individuals who felt relatively less satisfied with their relationships, less committed to their relationships, less invested in their relationships, and more taken for granted by their partners. Finally, I examined relationship initiation decisions in Studies 4 and 5. Single individuals were presented with the dilemma of whether or not to reject an
On helmholtz's principle for documents processing

Keyword extraction is a fundamental problem in text data mining and document processing. A large number of document processing applications directly depend on the quality and speed of keyword extraction algorithms. In this article, a novel approach to rapid change detection in data stream. and documents is developed. It is based on ideas from image processing and especially on the Helmholtz Principle from the Gestalt Theory of human perception. Applied to the problem of keywords extraction, it delivers fast and effective tools to identify meaningful keywords using parameter-free methods. We also define a level of meaningfulness of the keywords which can be used to modify the set of keywords depending on application needs.
Adaptive & discriminative speech modeling to cope with temporal changes of environments

The change in speech characteristics is originated from various factors, at various (temporal) rates in a real world conversation. These temporal changes have their own dynamics and therefore, we propose to extend the single (time-) incremental adaptations to a multiscale adaptation, which has the potential of greatly increasing the model’s robustness as it will include adaptation mechanism to approximate the nature of the characteristic change. The formulation of the incremental adaptation assumes a time evolution system of the model, where the posterior distributions, used in the decision process, are successively updated based on a macroscopic time scale in accordance with the Kalman filter theory. In this paper, we extend the original incremental adaptation scheme, based on a single time scale, to multiple time scales, and apply the method to the adaptation of both the acoustic model and the language model. We further investigate methods to integrate the multi-scale adaptation scheme to realize the robust speech recognition performance. Large vocabulary continuous speech recognition experiments for English and Japanese lectures revealed the importance of modeling multiscale properties in speech recognition.
A Distributed QoS MAC Protocol for Wireless Mesh

Abundant hidden node collisions and correlated channel access due to multi-hop flows degrade QoS in wireless mesh networks. QoS in nearby WLANs operating on a single channel is also affected. We propose using wider contention windows for backoff to lower the risk of repeated hidden-node collisions, a spatial extension of the TXOP concept called 'express forwarding' to clear multi-hop flows sooner, and a new mechanism called 'express re-transmission' to reduce collisions on retransmission. Simulation results show the potential benefit of the proposed enhancements and impact on fairness.
Stemming and n-grams in Spanish: an evaluation of their impact on information retrieval

At some stage, most of the models and techniques implemented in information retrieval use frequency counts of the terms appearing in documents and in queries. However, many words, since they are derived from the same stem, have very close semantic content. This makes a grouping of such variants under a single term advisable. Otherwise, dispersal occurs in the calculation of frequency of these terms and it also becomes difficult to compare queries and documents. On the other hand, there are notable differences between different languages in the way of forming derivatives and inflected forms, so that the application of specific techniques can produce unequal results according to the language of the documents and queries. A description is given of tests carried out for documents in Spanish, which involved some stemming techniques widely used in English, as well as the application of n-grams, and the results are compared.
Computers do better than experts matching faces in a large population

The performance of computer-based face recognition algorithms improves significantly recently. Although extensive evaluations of algorithms have been carried out, there has been little work on measuring the performance of experienced humans matching faces. We compared the face verification performance of 4504 experienced inspectors with a leading face recognition algorithm in a large population. Experts and algorithms determined whether face image pairs taken under real-world situation were pictures of the same person or not. The face recognition algorithm evidently surpassed experts on “easy” and “middle” face pairs, while on “hard” ones experts were superior to the algorithm. As a whole the algorithm outperformed experts on the face matching task. The distinct performance of the algorithm and experts on unfamiliar faces underscores the need to understand how much humans benefit from experience. It also suggested utilizing human-machine partnerships in security applications. A practical cascade system was proposed to reduce the workload of inspectors and achieve accuracy better than both experts and algorithms.
Assessment in Higher Education and Student Learning.

This research addressed ongoing academic concerns about whether assessment practices in higher education support student learning. Authors state that examinations have become the focus of assessment, which adversely affect learning. Effective assessment for learning promotes the active engagement of students. A web-based survey gathered information from a sample of postsecondary educators in Alberta. The questionnaire used the three criteria of learning-oriented assessment, tasks as learning tasks (authentic), selfand peer assessment, and feedback to determine learning potential. Findings illustrated that the implementation of only three of 15 authentic tasks occurred by over 30% of educators. Results also found that teachers have conflicting views relative to student use of feedback and the use of dialogue. These outcomes show that there is limited involvement of learners in assessment strategies, which can impact learning. It is recommended that teachers utilize professional development to understand how to optimize the active participation of students in various authentic assessment methods and feedback. Future research using a qualitative design should be conducted to obtain reasons why assessment problems exist.
Consciousness of the Future as a Matrix of Maybe: Pragmatic Prospection and the Simulation of Alternative Possibilities

Thinking about the future highlights the constructive nature of consciousness, as opposed to merely representing what is there—because the future is not yet available to be seen. We elaborate this point to emphasize how consciousness deals in alternative possibilities, and indeed preconscious interpretation confers meaning by recognizing these alternatives. Crucially, the goal of prospection is less to predict what is sure to happen than to prepare for action in situations defined by sets of incompatible alternative options, each of which might or might not come true. We review multiple lines of evidence indicating that people conceptualize the future as just such a matrix of maybe. Thus, people think of the future as highly changeable. Most prospective thinking involves planning, which is designed to bring about one outcome rather than alternatives. Optimism may often reflect an initial, automatic response that is soon followed by conscious appreciation of obstacles and other factors that can produce less desired, alternative outcomes. People moralize the future more than the past, presumably to promote the more desirable outcomes. Anticipated emotion helps people evaluate future possible outcomes. People specifically anticipate the matrix of maybe and sometimes seek to preserve multiplicity of options. We integrate these patterns of findings with a pragmatic theory of prospection: Thinking of the future as a multimaybe matrix is useful for guiding action.
A theory for deadlock-free dynamic network reconfiguration. Part I

This paper develops theoretical support useful for determining deadlock properties of dynamic network reconfiguration techniques and also serves as a basis for the development of design methodologies useful for deriving deadlock-free reconfiguration techniques. It is applicable to interconnection networks typically used in multiprocessor servers, network-based computing clusters, and distributed storage systems, and also has potential application to system-on-chip networks. This theory builds on basic principles established by previous theories while pioneering new concepts fundamental to the case of dynamic network reconfiguration.
Solvent properties of functionalized ionic liquids for CO2 absorption

Ionic liquids can be used as solvents for gas absorption operations in order to improve the process economy and general efficiency of gas separations. This work investigates solvent properties of ionic liquids and compares them to amine solutions used for absorption of carbon dioxide (CO2). The CO2 solubility into six different room temperature ionic liquids (RTILs) was measured at temperatures between 298 K and 343 K and pressures up to about 1 MPa. The RTILs used were: [bmim]+[BF4]−, [bmim]+[DCA]−, and four imidazolium-based ionic liquids paired with [DCA] and [BF4], in which the cation was functionalized with either a primary, tertiary amine or a hydroxyl group. The density, viscosity and surface tension of the studied RTILs were measured at temperatures ranging from 293 K up to 363 K. The results showed that CO2 absorption behaviour was influenced by the functionalized chains appended to the RTILs cation. A chemical enhancement of the CO2 absorption was observed when functionalized RTILs were used as absorption solvents. It was possible to increase the ionic liquid volumetric gas load almost threefold by attaching functional groups to the ionic liquid, whereas for the traditional amine solutions the maximum gas load is stoichiometrically limited.