Miracle-dz/UniFAR-FTUs huggingface dataset:
Dysregulation of regional endogenous opioid function in borderline personality disorder.

OBJECTIVE Borderline personality disorder is characterized by a lack of effective regulation of emotional responses. The authors investigated the role of the endogenous opioid system and mu-opioid receptors in emotion regulation in borderline personality disorder. METHOD Mu-opioid receptor availability in vivo (nondisplaceable binding potential, or BP(ND)) was measured with positron emission tomography and the selective radiotracer [(11)C]carfentanil during neutral and sustained sadness states in 18 unmedicated female patients with borderline personality disorder and 14 healthy female comparison subjects. RESULTS Patients showed greater regional mu-opioid BP(ND) than did comparison subjects at baseline (neutral state) bilaterally in the orbitofrontal cortex, caudate, and nucleus accumbens and in the left amygdala, but lower BP(ND) in the posterior thalamus. Sadness induction was associated with greater reductions in BP(ND) (endogenous opioid system activation) in the patient group than in the comparison group in the pregenual anterior cingulate, left orbitofrontal cortex, left ventral pallidum, left amygdala, and left inferior temporal cortex. Patients showed evidence of endogenous opioid system deactivation in the left nucleus accumbens, the hypothalamus, and the right hippocampus/parahippocampus relative to comparison subjects. Correlations of baseline measures with the Dissociative Experiences Scale and endogenous opioid system activation with the Barratt Impulsiveness Scale did not remain significant after correction for multiple comparisons. CONCLUSIONS Differences exist between patients with borderline personality disorder and comparison subjects in baseline in vivo mu-opioid receptor concentrations and in the endogenous opioid system response to a negative emotional challenge that can be related to some of the clinical characteristics of patients with borderline personality disorder. The regional network involved is implicated in the representation and regulation of emotion and stress responses.
Mutational Analysis of the Base Flipping Event Found in Tn5 Transposition*

This work identifies novel structure-function relationships between Tn5 transposase (Tnp) and its DNA recognition sequence. The Tn5 Tnp-DNA co-crystal structure revealed the protein-DNA contacts of the post-cleavage complex (Davies, D. R., Goryshin, I. Y., Reznikoff, W. S., and Rayment, I. (2000) Science 289, 77–85). One of the most striking features of this complex is the rotation of thymine 2 (T2) away from the DNA helix and into a pocket within the Tnp. This interaction appears similar to the “base flipping” phenomenon found in many DNA repair enzymes such as T4 endonuclease V and uracil DNA glycosylase (Roberts, R. J., and Cheng, X. (1998) Annu. Rev. Biochem. 67, 181–198). To study the biochemical significance of this phenomenon, we mutated the Tnp residues proposed to be involved in stabilizing this interaction and removed the T2 nucleotide to examine which steps in the transposition reaction require T2-Tnp interactions. From this work, we have determined that stacking interactions between T2 and Tnp are critical for efficient transposition in vitro. In addition, our results suggested that T2-Tnp interactions facilitate hairpin formation and hairpin resolution primarily through base stacking and that T2 plays a role in the alignment of the transposon DNA for strand transfer.
Visual landmarks sharpen grid cell metric and confer context specificity to neurons of the medial entorhinal cortex

Neurons of the medial entorhinal cortex (MEC) provide spatial representations critical for navigation. In this network, the periodic firing fields of grid cells act as a metric element for position. The location of the grid firing fields depends on interactions between self-motion information, geometrical properties of the environment and nonmetric contextual cues. Here, we test whether visual information, including nonmetric contextual cues, also regulates the firing rate of MEC neurons. Removal of visual landmarks caused a profound impairment in grid cell periodicity. Moreover, the speed code of MEC neurons changed in darkness and the activity of border cells became less confined to environmental boundaries. Half of the MEC neurons changed their firing rate in darkness. Manipulations of nonmetric visual cues that left the boundaries of a 1D environment in place caused rate changes in grid cells. These findings reveal context specificity in the rate code of MEC neurons. DOI: http://dx.doi. org/10.7554/eLife.16937. 001
On pro-p fundamental groups of marked arithmetic curves

Let k be a global field, p an odd prime number dierent from char (k) and S, T disjoint, finite sets of primes of k. Let G T(k)(p) = G(k T(p)|k) be the Galois group of the maximal p-extension of k which is unramified outside S and completely split at T. We prove the existence of a finite set of primes S0, which can be chosen disjoint from any given setM of Dirichlet density zero, such that the cohomology of G T[S0 (k)(p) coincides with the etale cohomology of the associated marked arithmetic curve. In particular, cd G T[S0 (k)(p) = 2. Furthermore, we can choose S0 in such a way that k T S[S0 (p) realizes the maximal p-extension kp(p) of the local field kp for all p2 S[S0, the cup-product H 1 (G T[S0 (k)(p),Fp) H 1 (G T[S0 (k)(p),Fp)! H 2 (G T[S0 (k)(p),Fp) is surjective and the decomposition groups of the primes in S establish a free product inside G T[S0 (k)(p). This generalizes previous work of the author where similar results were shown in the case T = ? under the restrictive assumption p - #Cl(k) and p / 2 k.
Violent Offenders in Drug Court

Drug courts are slowly beginning to expand their admission criteria to include more chronic and serious offenders since traditional probation and incarceration have failed to prevent drug use and crime. Drug courts have moved from providing diversion programs for first-time offenders charged with drug possession to developing tracks for more complex clients. Many of these new drug court participants have extensive criminal histories, including histories of violent crime. Drug court decision-makers thus confront the difficulty of balancing the needs of treatment versus corrections by attempting to target offenders whose criminal histories suggest that their candidacy in a drug court would not pose a risk to public safety. To date, little is known about whether drug courts are appropriate for offenders with lengthy criminal histories that often include violence. The research presented here explores correlates of drug court graduation for seriously crime-involved offenders, most of whom have a history of violence.
Recursive linear orders with incomplete successivities

A recursive linear order is said to have intrinsically complete successivities if, in every recursive copy, the succ;essivities form a complete set. We show (Theorem 1) that there is a recursive linear order with intrinsically complete successivities but (Theorem 2) that this cannot be a discrete linear oder. We investigate the related issues of intrinsically non-low and non-semilow successivities in discrete linear orders. We show also (Theorem 3) that no recursive linear order has intrinsically wtt-complete successivities.
The Globalization of Martyrdom: Al Qaeda, Salafi Jihad, and the Diffusion of Suicide Attacks

This groundbreaking volume examines the rise and spread of suicide attacks over the past decade. Sorting through 1,270 terror strikes between 1981 and 2007, Assaf Moghadam attributes their recent proliferation to the mutually related ascendance of al Qaeda and its guiding ideology, Salafi Jihad, an extreme interpretation of Islam that rejects national boundaries and seeks to create a global Muslim community. In exploring the roots of the extreme radicalization represented by Salafism, Moghadam finds many causes, including Western dominance in the Arab world, the physical diffusion of Salafi institutions and actors, and the element of opportunity created by the Soviet invasion of Afghanistan. He uses individual examples from the Middle East, Southwest Asia, and Europe to show how the elite leaders of al Qaeda and affiliated groups and their foot soldiers interact with one another and how they garner support-and a growing number of converts and attackers-from the Muslim community. Based on over a decade of empirical research and a critical examination of existing thought on suicide attacks, Moghadam distinguishes the key characteristics separating globalized suicide strikes from the traditional, localized pattern that previously prevailed. This unflinching analysis provides new information about the relationship between ideology and suicide attacks and recommends policies focused on containing Salafi Jihadism.
STRUCTURE ANALYSIS OF SINGLE- AND MULTI- FREQUENCY SUBSPACE MIGRATIONS IN INVERSE SCATTERING PROBLEMS

We carefully investigate the structure of single- and multi- frequency imaging functions, that are usually employed in inverse scattering problems. Based on patterns of the singular vectors of the Multi-Static Response (MSR) matrix, we establish a relationship between imaging functions and the Bessel function. This relationship indicates certain properties of imaging functions and the reason behind enhancement in the imaging performance by multiple frequencies. Several numerical simulations with a large amount of noisy data are performed in order to support our investigation.
Major workplace related accidents in Singapore: A major trauma centre's experience.

INTRODUCTION Major workplace related accidents pose a significant healthcare resource challenge in Singapore. MATERIALS AND METHODS Our study looks at the epidemiology of patients who were admitted for workplace related accidents, in a single institution, with an Injury Severity Score of >9. RESULTS There were 196 cases of major workplace related accidents admitted between January 2006 and December 2007. The median age of patients admitted was 37 years with a large percentage being males (95.4%) and non-residents (57.1%). The most common ethnic group was Chinese (53.1%) followed by Indians (23.5%). The most common mechanism of injury was fall from height (66.3%) followed by injuries as a result of falling objects at work (21.9%). The percentage of patients who required surgical intervention was 69.9%. Patients admitted for major workplace related accidents had a median length of stay of 5 days in the hospital, a median length of 24 days of medical leave (ML), certifying them unfit for duty and the average cost of stay for each patient was S$11,000. CONCLUSIONS We have a better understanding of the epidemiology and socio-economic impact of workplace related accidents through this study. Workplace related accidents result in significant number of man-days lost from work and monetary cost to employers, medical insurance and the hospital. With an improved understanding, we propose methods to prevent and reduce such accidents in future. A direct consequence of which will be the possible reduction of hospitalisation costs and better allocation of healthcare resources in the future.
Constructing Fama-French Factors from style indexes: Japanese evidence

One feature that potentially makes the Fama-French (FF) three-factor model less appealing than the Capital Asset Pricing Model (CAPM) is the complexity of the FF model versus simplicity of the CAPM. This motivates us to construct simple benchmarks for FF factors in Japanese market by using four commercially available Daiwa style indexes. The performance of benchmark choice is evaluated through a direct and simple generalized method of moments (GMM) test. Our simply constructed FF factors can explain returns on 33 industry indexes of all common stocks listed on the first section of Tokyo Stock Exchange. Taken FF risk premiums into consideration, finding on a reversal of size effect during post-bubble period confirms similar findings from previous literature.
DISAPPEARING TRAFFIC? THE STORY SO FAR

Reallocating roadspace from general traffic, to improve conditions for pedestrians or cyclists or buses or on-street light rail or other high-occupancy vehicles, is often predicted to cause major traffic problems on neighbouring streets. This paper reports on two phases of research, resulting in the examination of over 70 case studies of roadspace reallocation from eleven countries, and the collation of opinions from over 200 transport professionals worldwide. The findings suggest that predictions of traffic problems are often unnecessarily alarmist, and that, given appropriate local circumstances, significant reductions in overall traffic levels can occur, with people making a far wider range of behavioural responses than has traditionally been assumed. Follow-up work has also highlighted the importance of managing how schemes are perceived by the public and reported in the media, with various lessons for avoiding problems. Finally, the findings highlight that well-designed schemes to reallocate roadspac.
Bubble Troubles? Rational Storage, Mean Reversion and Runs in Commodity Prices

High and volatile prices of major commodities have generated a wide array of analyses and policy prescriptions, including influential studies identifying price bubbles in periods of high volatility. Here we consider a model of the market for a storable commodity in which price expectations are unbounded. We derive its implications for price time series and empirical tests of price behavior. In this model commodity price is equal to marginal consumption value, and hence bubbles as defined in financial economics cannot occur. However the model generates episodes of price runs that could be characterized as "explosive" and might seem to be bubble-like. At sufficiently long holding periods, a price path can yield average returns consistent with mean reversion, even though the long run expectation of price is infinite.
Succession in family business: multi-source perspectives

Purpose Despite the extensive breadth of research into the critical challenge of succession in family business, generational succession in family business has been investigated from predominately one-dimensional perspective. The purpose of this paper is to respond to call for a multi-perspectives examination of leadership succession in order to embrace the dynamic and complex nature of succession in a family business. Accordingly, the authors investigated the key personal and professional factors associated with effective family-business succession across four key stakeholders: incumbent, successor, family, and nonfamily members. Design/methodology/approach The explanatory research design included 16 interviews in Phase 1 and 41 prospective case study interviews in Phase 2, both with Australian family businesses that had or were about to experience generational transition. Findings Incumbents and successor interview findings support the benefits of maintaining a cohesive family business, adaptable family culture, and familiness for effective succession. The authors also identified several personal components (e.g. family-business socialization and external experiences) that can help determine the commitment of successors and how this commitment can change once they assume a leadership position. Business size was the professional component supported by incumbent, successor, and nonfamily members as having a significant impact on succession process. As family business grows and becomes more highly complex, a clearly defined set of procedures become imperative. Practical implications Family-business practitioners can apply the findings to manage the processes and expectations of family and the business to achieve effective generational succession and thereby increase the sustainability of the business. Originality/value This research provides a coherent and comprehensive understanding of the interdependencies of competing priorities in the complex succession process that is essential for family-business sustainability and performance.
Evaluating "Quality" Methods of Filling the "Teacher Gap": Results of a Pilot Study with Early Career Teachers

Challenges for meeting the highly-qualified teacher demand, exacerbated by the critical shortage of teachers, have necessitated a variety of preparation routes for those entering the profession of teaching. This pilot study examined teacher confidence and self efficacy related to teacher preparedness within the first three years of employment. Specifically, the study examined preparation experience perceptions of early career teachers. All teachers who were employed three years or less from three Florida school districts were invited to participate. Data were analyzed and aggregated according to teacher preparation type – traditional or non-traditional (alternative) program. Participants indicated their likelihood of remaining in the program, district, and school as well as their degrees of confidence in preparation for the competencies identified. Overall results as well as differences between those who completed a traditional teacher preparation program and those with a non-traditional teacher preparation program are presented. Implications for training priorities and replicating research are discussed.
“Just Trying to Keep the Customer Satisfied”

SUMMARY The paper compares the predictive validity of six models used in the measurement of satisfaction; it is concerned with their application at destination level, with particular reference to Orlando, Florida. Using factor analysis and multiple regression, the ‘performance only’ model was clearly identified as the best predictor of satisfaction. The incorporation of ‘importance’ and ‘performance’ ratings did not improve the predictive power of the ‘performance only’ solution. From tourists' ‘performance’ ratings, five ‘dimensions’ of Orlando's tourism offering were identified: ‘primary,’ ‘secondary’ and ‘tertiary’ attractions, ‘facilitators’ and ‘transport plus. ’ Notwithstanding Orlando's reputation as the world's theme park capital, Orlando's ‘secondary’ attractions (such as shopping and dining opportunities) and ‘facilitators’ (such as accommodation and customer service) were identified as having the most influence on overall tourist satisfaction with Orlando.
Fast algorithms for simulating chiral fermions in U(1) lattice gauge theory

Lattice QCD with chiral fermions are extremely computationally expensive, but on the other hand provides an accurate tool for studying the physics of strong interactions. Since the truncated overlap variant of domain wall fermions are equivalent to overlap fermions in four dimensions at any lattice spacing, in this paper we have used domain wall fermions for our simulations. The physical information of lattice QCD theory is contained in quark propagators. In practice computing quark propagator in lattice is an inversion problem of the Dirac operator matrix representing this quarks. In order to develop fast inversion algorithms we have used overlap solvers in two dimensions. Lattice QED theory with U(1) group symmetry in two dimensional space-times dimensions has always been a testing ground for algorithms. By the other side, motivated by our previews work that the two-grid algorithm converge faster than the standard iterative methods for overlap inversion but not for all quark masses, we thought to test this idea in less dimensions such as U(1) gauge theory. Our main objective of this paper it is to implement and develop the idea of a two level algorithm in a new algorithm coded in QCDLAB. This implementation is presented in the preconditioned GMRESR algorithm, as our new contribution in QCDLAB package. The preconditioned part of our algorithm, different from the one of [18], is the approximation of the overlap operator with the truncated overlap operator with finite N3 dimension. We have tested it for 100 statistically independent configurations on 32 x 32 lattice background U(1) field at coupling constant and for different bare quark masses mq = [0.5, 0.45, 0.4, 0.35, 0.3, 0.25, 0.2, 0.15, 0.1]. We have compared the convergence history of the preconditioned GMRESR residual norm with another overlap inverter of QCDLAB as an optimal one, such as SHUMR. We have shown that our algorithm converges faster than SHUMR for different quark masses. Also, we have demostrated that it saves more time for light quarks compared to SHUMR algorithm. Our algorithm is approximately independent from the quark mass. This is a key result in simulations with chiral fermions in lattice theories. By the other side, if we compare the results of [18] for quark mass 0.1 in SU(3), results that our chosen preconditioned saves a factor of 2. Our next step is to adopt this algorithm in parallel. Keywords: chiral fermions, quark propagator, inverting algorithms, U (1) gauge theory.
The case for dynamic subsidence of the U.S. east coast since the Eocene

The dynamic subsidence of the United States east coast is addressed using the discrepancy between regional and global estimates of sea level, elevation of paleoshorelines, and adjoint models of mantle convection that assimilate plate motions and seismic tomography. The positions of Eocene and Miocene paleoshorelines are lower than predicted by global sea levels, suggesting at least 50 m, and possibly as much as 200 m of subsidence since the end of the Eocene. Dynamic models predict subsidence of the east coast since the end of Eocene, although the exact magnitude is uncertain. This subsidence has been occurring during an overall global sea‐level fall, with the eustatic change being larger than the dynamic subsidence; this results in a regional sea‐level fall in the absence of land subsidence. Dynamic subsidence is consistent with the difference between eustasy and regional sea level at the New Jersey coastal plain.
Column-Matching Based BIST Design Method

A new method of test-per-clock BIST design for combinational circuits is proposed. The fundamental problem of matching the PRPG outputs with the required test patterns is solved as a general design problem in the field of combinational logic. A test set generated by an ATPG is compared with the PRPG generated sequence. The solution is based on a novel search algorithm, which identifies the best matches between the pairs of columns of the two sets.
Distributional Dynamics Under Smoothly State-Dependent Pricing

Starting from the assumption that firms are more likely to adjust their prices when doing so is more valuable, this paper analyzes monetary policy shocks in a DSGE model with firm-level heterogeneity. The model is calibrated to retail price microdata, and inflation responses are decomposed into “intensive”, “extensive”, and “selection” margins. Money growth and Taylor rule shocks both have nontrivial real effects, because the low state dependence implied by the data rules out the strong selection effect associated with fixed menu costs. The response to sector-specific shocks is gradual, but inappropriate econometrics might make it appear immediate.
Analysis of Energy Consumption for Ad Hoc Wireless Sensor Networks Using a Bit-Meter-per-Joule Metric

In this article, we present a system-level characterization of the energy consumption for sensor network application scenarios. We compute a power efficiency metric—average watt-per-meter—for each radio transmission and extend this local metric to find the global energy consumption. This analysis shows how overall energy consumption varies with transceiver characteristics, node density, data traffic distribution, and base-station location.