Miracle-dz/UniFAR-FTUs huggingface dataset:
Implant survival after preparation of the implant site using a single bur: a case series.

BACKGROUND Implant site preparation usually consists of several consecutive drilling steps, performed using different burs with increasing diameter. PURPOSE The purpose of the present study was to report the clinical outcomes of edentulous patients that underwent implant treatment, in which a special bur that allows preparation of the implant site in a single drilling step was used. MATERIAL AND METHODS One hundred forty-nine patients (79 males, 70 females, mean age 51.8 ± 12.2 [SD] years, range 20-80 years) have been rehabilitated using different oral surgery procedures. A total of 350 implants were inserted (171 in the maxilla and 179 in the mandible). A barrier membrane was used for covering a total of 126 implants. Fifteen implants were placed by using the osteotome technique and 52 by using the lateral sinus lift procedure. Eighty-nine implants were placed in postextraction sockets. Thirty-six implants underwent immediate loading. Implant survival, peri-implant bone level change, and patients' satisfaction were the main variables assessed. RESULTS No patient dropout occurred. The mean follow-up on a patient basis was 21.5 ± 3.1 months (range 12-27 months). A total of seven implant failures were recorded in six patients, leading to a mean implant survival of 98.0% (96.0% on a patient basis). The mean peri-implant bone loss after 1 year was 0.58 ± 0.44 mm (n = 282). Apart from implant failures, no biological nor mechanical complications occurred. All patients demonstrated full satisfaction. CONCLUSIONS The use of a single bur for implant site preparation allows the reduction of the time needed for the surgical procedure, without compromising the clinical outcomes. Further, long-term comparative studies are needed to confirm the results of this study.
The (pro)renin receptor blocker handle region peptide upregulates endothelium-derived contractile factors in aliskiren-treated diabetic transgenic (mREN2)27 rats

Background: Elevated prorenin levels associate with microvascular complications in patients with diabetes mellitus, possibly because prorenin affects vascular function in diabetes mellitus, for example by generating angiotensins following its binding to the (pro)renin receptor [(P)RR]. Here we evaluated whether the renin inhibitor aliskiren, with or without the putative (P)RR antagonist handle region peptide (HRP) improved the disturbed vascular function in diabetic TGR(mREN2)27 rats, a high-prorenin, high-(P)RR hypertensive model. Methods: Telemetry transmitters were implanted to monitor blood pressure. After 3 weeks of treatment, rats were sacrificed, and iliac and mesenteric arteries were removed to evaluate vascular reactivity. Results: Diabetes mellitus enhanced the contractile response to nitric oxide synthase (NOS) blockade, potentiated the response to phenylephrine, diminished the effectiveness of endothelin type A (ETA) receptor blockade and allowed acetylcholine to display constrictor, cyclo-oxygenase-2 mediated, endothelium-dependent responses in the presence of NOS inhibition and blockers of endothelium-derived hyperpolarizing factors. Aliskiren normalized blood pressure, suppressed renin activity, and reversed the above vascular effects, with the exception of the altered effectiveness of ETA receptor blockade. Remarkably, when adding HRP on top of aliskiren, its beneficial vascular effects either disappeared or were greatly diminished, although HRP did not alter the effect of aliskiren on blood pressure and renin activity. Conclusions: Renin inhibition improves vascular dysfunction in diabetic hypertensive rats, and HRP counteracts this effect independently of blood pressure and angiotensin. (P)RR blockade therefore is unlikely to be a new tool to further suppress the renin–angiotensin system (RAS) on top of existing RAS blockers.
Minimizing the real functions of the ICEC'96 contest by differential evolution

Differential Evolution (DE) has recently proven to be an efficient method for optimizing real-valued multi-modal objective functions. Besides its good convergence properties and suitability for parallelization, DE's main assets are its conceptual simplicity and ease of use. This paper describes two variants of DE which were used to minimize the real test functions of the ICEC'96 contest.
Moving forward: A problem-solving training program to foster veteran resilience.

It is vital for mental health professionals serving veterans to be able to address the full range of needs presented by returning veterans, including those that affect a veterans’ daily life (e.g., relationships, employment, and community functioning) but may not rise to the level of requiring specialty mental health care. This article describes the development and evaluation of an innovative Veterans Affairs program, Moving Forward, which focuses on building resilience and reducing emotional distress. Moving Forward is based on the principles of problem-solving therapy that have been adapted for use in a four-session, classroom-based training program for veterans. The program evaluation results indicate that Moving Forward is feasible, well-received by veterans, and yields improvements in social problem solving, resilience, and overall distress levels. Although there is a strong evidence base for problemsolving therapy in a range of clinical settings and with a variety of patient populations (Nezu et al., 2013), this represents the first effort to apply these principles in a program focusing on the readjustment and resilience of our nation’s veterans. We include several recommendations for building on these results, including the use of Internet-based training, inclusion of family members in training, and recommendations for research in this important area.
Role of exosomes in hepatocellular carcinoma cell mobility alteration

Exosomes have gained increased research focus due to their key roles as messengers. The components of exosomes include proteins and RNAs that may be horizontally transferred between adjacent or distant cells. Hepatocellular carcinoma (HCC) is among the most malignant types of cancer worldwide, with exosomes implicated to play a crucial role in its regulation; however, the possible function of exosomes in modulating the motile ability of tumor cells and key molecules in HCC remain largely unknown. To investigate the regulatory effect of exosomes on the motile ability of HCC cells, exosomes from the culture medium of different HCC origins (high metastatic MHCC97-H and low metastatic MHCC97-L cells) were isolated for in vitro migration and invasion assays. The results indicated that the motile ability of MHCC97-L cells was significantly increased by pretreatment with MHCC97-H-derived exosomes when compared with MHCC97-L-exosome pretreatment (P<0.05). To further characterize the function of exosomes at the molecular level, protein profiling of exosomes from different cell origins was performed, which identified 129 proteins. Among these, adenylyl cyclase-associated protein 1, a protein implicated in HCC metastasis, was significantly enriched in exosomes from cells with high motile ability (P<0.05). The results of the present study validated the regulatory effect of exosomes on the motile ability of HCC cells. Furthermore, systematic analysis of the protein profiles of exosomes from different origins identified potential factors correlated with HCC metastasis, which may provide a basis for future functional analysis of exosomes regarding their involvement in cancer metastasis and recurrence.
Application of the Transtheoretical Model to Exercise Behavior among Nontraditional College Students

Abstract This study examined the applicability of the Transtheoretical Model (TTM) to understanding exercise behavior among a sample of nontraditional college students at a southwestern university. A cross-sectional descriptive study was conducted. The independent variable was stage of exercise behavior change. The dependent variables analyzed were exercise efficacy expectations, decisional balance (i.e., pros and cons), and the processes of change. Six hundred and eighty students (mean age = 27.45 ± 8.2 years, 62.0% female, 85.9% Caucasian) representing various disciplines on campus (e.g., education, engineering) completed valid and reliable questionnaire packets during regularly scheduled classes. Fifty-nine percent of the sample were sedentary or exercised irregularly (precontemplation [PC], contemplation, or preparation stages), whereas 17% were in the action stage (A, regularly active <6 months) and 23% were in the maintenance stage (M, regularly active ≥6 months). Results revealed that all of the TTM constructs differed significantly across exercise stages. Students in PC scored the lowest and those in M scored the highest on efficacy expectations and pros, with the pattern reversed on cons. Use of processes of change generally increased steadily from PC to A and then leveled off. Results support the use of the entire TTM in examining exercise behavior among nontraditional college students.
A Critical Time Window for the Recruitment of Bulbar Newborn Neurons by Olfactory Discrimination Learning

In the mammalian brain, the dentate gyrus and the olfactory bulb are regions where new neurons are continuously added. While the functional consequences of continuous hippocampal neurogenesis have been extensively studied, the role of olfactory adult-born neurons remains elusive. In particular, the involvement of these newborn neurons in odor processing is still a matter of debate. We demonstrate a critical impact of both the age of new neurons and the memory processes involved (learning vs recall) in the recruitment of newborn cells. Thus, odor stimulation preferentially recruited immature neurons over more mature ones (2 weeks old vs 5 and 9 weeks old), whereas associative learning based on odor discrimination preferentially recruited mature neurons (5–9 weeks old). Furthermore, while mature neurons were activated by this associative learning, they were not activated by long-term memory recall, indicating that the contribution of newborn neurons in olfactory functions depends also on the memory process involved. Our data thus show that newborn neurons are indeed involved in odor processing and that their recruitment is age- and memory process-dependent.
The Limits of Individual Identification from Sample Allele Frequencies: Theory and Statistical Analysis

It was shown recently using experimental data that it is possible under certain conditions to determine whether a person with known genotypes at a number of markers was part of a sample from which only allele frequencies are known. Using population genetic and statistical theory, we show that the power of such identification is, approximately, proportional to the number of independent SNPs divided by the size of the sample from which the allele frequencies are available. We quantify the limits of identification and propose likelihood and regression analysis methods for the analysis of data. We show that these methods have similar statistical properties and have more desirable properties, in terms of type-I error rate and statistical power, than test statistics suggested in the literature.
Therapeutic Discovery In Situ Vaccination with CD 204 Gene-Silenced Dendritic Cell , not Unmodi fi ed Dendritic Cell , Enhances Radiation Therapy of Prostate Cancer

Given the complexity of prostate cancer progression and metastasis, multimodalities that target different aspects of tumor biology, for example, radiotherapy in conjunction with immunotherapy, may provide the best opportunities for promoting clinical benefits in patients with high-risk localized prostate cancer. Here, we show that intratumoral administration of unmodified dendritic cells (DC) failed to synergize with fractionated radiotherapy. However, ionizing radiation combined with in situ vaccination with DCs, in which the immunosuppressive scavenger receptor A (SRA/CD204) has been downregulated by lentivirusmediated gene silencing, profoundly suppressed the growth of two mouse prostate cancers (e.g., RM1 and TRAMP-C2) and prolonged the lifespan of tumor-bearing animals. Treatment of subcutaneous tumors with this novel combinatorial radioimmunotherapeutic regimen resulted in a significant reduction in distant experimental metastases. SRA/CD204-silenced DCs were highly efficient in generating antigen or tumorspecific T cells with increased effector functions (e.g., cytokine production and tumoricidal activity). SRA/ CD204 silencing-enhanced tumor cell death was associated with elevated IFN-g levels in tumor tissue and increased tumor-infiltrating CD8þ cells. IFN-g neutralization or depletion of CD8þ cells abrogated the SRA/CD204 downregulation-promoted antitumor efficacy, indicating a critical role of IFN-g–producing CD8þ T cells. Therefore, blocking SRA/CD204 activity significantly enhances the therapeutic potency of local radiotherapy combined with in situ DC vaccination by promoting a robust systemic antitumor immunity. Further studies are warranted to test this novel combinatorial approach for translating into improved clinical outcomes in patients with prostate cancer.Mol Cancer Ther; 11(11); 2331–41. 2012 AACR.
Teacher-perceived principal leadership styles, decision-making styles and job satisfaction: how congruent are data from Indonesia with the Anglophile and Western literature?

ABSTRACT School leadership is seen as important for both schools and for government and private policy-makers. The relationships between teacher-perceived principal leadership styles, teacher-perceived principal decision-making styles and teacher-perceived job satisfaction in schools in Lampung Province, Indonesia were examined. Data were collected by questionnaires from 475 teachers. This paper uses Indonesian data, but the relationships studied will be of wider interest to school stakeholders in Indonesia and to a wider global readership. Considerable effort was placed on the collection of robust data to address existing gaps in the literature about these relationships. The data are available to be shared with other interested parties. Findings suggest that five variables (of the nine variables that were studied) can significantly (p < .001) predict teacher job satisfaction. Transformational leadership style and rational decision-making style are the best predictors and are likely to contribute to increased teacher job satisfaction. In contrast, laissez-faire leadership style, intuitive decision-making style and avoidant decision-making style are likely to contribute to decreased teacher job satisfaction. This paper is the third paper of five papers about school leadership in Indonesia.
Thermal Comfort and Indoor Air Quality of Task Ambient Air Conditioning in Modern Office Buildings

Energy and environmental sustainability is a major global trend for the 21st century. Thermal discomfort and poor air quality in office buildings can result in loss of productivity, absenteeism and medical problems. The most frequently identified causes are related to inadequate ventilation and contaminants from indoor sources. Task ambient air conditioning aims to provide each occupant with personalized clean air direct to the breathing zone. A typical modern office is selected to study the thermal comfort and indoor air quality of the working environment. The temperature distribution, draught rating, volume concentration of the contaminants and ventilation efficiencies for the contaminants are calculated. For fresh air is directly to sent to breathing zone of the occupants by the task air outlet, the temperature, the CO2 concentration and benzene concentration around the occupants are lower than that of the other zones. And ventilation efficiencies for both the CO2 and benzene around occupants are also higher. These show the effectiveness of the task ambient air conditioning system in forming energy-saving, comfort and clean environment.
Cross-Disciplinary Applications of I/O Psychology Concepts: Predicting Student Retention and Employee Turnover

Two survey investigations conducted over a 2-year period serve as a case study illustrating how research that crosses disciplinary boundaries can shed light on current conceptual and methodological issues in student retention. Specifically, we applied the concepts of organizational commitment and job embeddedness used by industrial/organizational psychologists in the study of employee turnover to an investigation of factors that influence college student retention and withdrawal. The present research models the cross-disciplinary approach by examining the associations between embeddedness (including links, fit, sacrifice) and organizational commitment, and focusing on their ability to predict students' intentions to leave and, longitudinally, to predict actual departure prior to graduation. The case study demonstrates how understanding a particular behavior in one domain, that of education, is advanced by taking an approach from outside that discipline. Similarly, concepts from I/O psychology and management become clarified when applied outside their own boundaries.
Evaluation of Tumor necrosis factor-alpha in patients with Coronary Artery Disease

Background: Tumor necrosis factor-α (TNF-α) is a multifunctional circulating cytokine derived from endothelial and smooth muscle cells as well as macrophages associated with coronary atheroma. A large number of genetic and epidemiological studies have identified TNF-α as a risk factor for atherosclerotic disease such as Coronary Artery disease and stroke. Based on our knowledge, this is the first study to estimate serum TNF-α concentration in Manipur. Aims and objective: The study was conducted to estimate serum TNF-α in Coronary Artery Disease patients, and its correlation with lipid parameters, blood glucose and anthropometric measurements. Materials and Methods: Study was carried out in 112 CAD patients as cases and 56 healthy subjects as controls. TNF-α was measured by ELISA reader using human TNF-α kit of Krishgen Biosystem. Results: Mean serum TNF-α level in CAD patients group was significantly higher than the healthy control. Serum TNF-α was also significantly higher in males than females in both study groups and control subjects. The difference is statistically significant in ACS and CSA group is evident by P-value<0.05. Conclusion:Our study revealed that coronary artery disease patients have elevated levels of serum TNF-α as compared to healthy subjects. High concentration of serum TNF-α is strongly associated with risk of Coronary Artery Disease.
Short-term Results of Trabeculectomy Using Adjunctive Intracameral Bevacizumab: A Randomized Controlled Trial

Purpose:To investigate the outcome of trabeculectomy with or without adjunctive intracameral bevacizumab. Materials and Methods:In this prospective, double-blind, randomized clinical trial, 71 patients with primary open-angle or pseudoexfoliation glaucoma were randomly assigned to receive either 1.25 mg intracameral bevacizumab (n=36) or balanced salt solution as placebo (n=35) at the end of trabeculectomy. Success was defined as at least a 30% drop in intraocular pressure (IOP) compared with baseline values and an IOP between 6 and 21 mm Hg at the last postoperative visit with (qualified) or without (complete) glaucoma medications. Results:Thirty-two patients in bevacizumab group and 33 in placebo group completed a mean follow-up of 10.7±2.1 and 10.5±2.5 months, respectively (P=0.731). The mean preoperative IOP was 28.25±5.64 and 29.11±4.65 mm Hg in the bevacizumab and placebo groups, respectively (P=0.485). Last visit IOP was 14.5±3.7 mm Hg in the bevacizumab group and 18.55±3.64 mm Hg in the placebo group (P<0.001). At last visit, complete success was achieved in 26 cases (81.3%) of bevacizumab group and 16 cases (48.5%) of placebo group (P<0.006). Filtering bleb leak during the first postoperative month was seen in 11 (34%) and in 3 (9%) cases of bevacizumab and placebo groups, respectively (P=0.013). Conclusions:A single 1.25 mg dose of intracameral bevacizumab significantly improves the success of trabeculectomy; however, it increases the risk of early filtering bleb leakage.
Impact of Library-Based Summer Reading Clubs on Primary-Grade Children’s Literacy Activities and Achievement

The purpose of this study was to examine the literacy activities and achievements of primary-grade children participating in summer reading clubs (SRC) and determine whether participation in SRC impacted primary-grade children’s literacy activities and achievements. To address these research aims, 90 second- and third-grade children were randomly assigned to either a treatment (Marathon) or control (Sprint) group. Children and their caregivers completed questionnaires on children’s literacy activities, and children’s achievements were measured using direct assessment of their decoding and reading comprehension skills. Results of this study suggested that primary-grade children who elect to participate in SRC engage in frequent literacy activities and are average decoders and comprehenders. Participation in SRC does not seem to impact children’s literacy activities or achievements. However, by the end of the summer, all children made significant gains in reading comprehension. Implications including how to increase the effectiveness of SRC are discussed.
Blastopathies and microcephaly in a Chornobyl impacted region of Ukraine

This population‐based descriptive epidemiology study demonstrates that rates of conjoined twins, teratomas, neural tube defects, microcephaly, and microphthalmia in the Rivne province of Ukraine are among the highest in Europe. The province is 200 km distant from the Chornobyl site and its northern half, a region known as Polissia, is significantly polluted by ionizing radiation. The rates of neural tube defects, microcephaly and microphthalmia in Polissia are statistically significantly higher than in the rest of the province. A survey of at‐birth head size showed that values were statistically smaller in males and females born in one Polissia county than among neonates born in the capital city. These observations provide clues for confirmatory and cause‐effect prospective investigations. The strength of this study stems from a reliance on international standards prevalent in Europe and a decade‐long population‐based surveillance of congenital malformations in two distinct large populations. The limitations of this study, as those of other descriptive epidemiology investigations, is that identified cause‐effect associations require further assessment by specific prospective investigations designed to address specific teratogenic factors.