Miracle-dz/UniFAR-FTUs huggingface dataset:
Standard German vowel productions by monolingual and trilingual speakers

Aims and Objectives: Studies on vowel productions of speakers from bilingual communities report not only interactions between the first and second language, but also monolingual-like realizations. The present study expands a prior acoustic investigation of Saterland trilinguals by studying the substrate effect of Saterland Frisian and Low German on the trilinguals’ standard language Northern Standard German. The research aim is to test whether the Northern Standard German vowel productions of the Saterland trilinguals approach the productions of monolingual speakers in terms of durational and spectral features. Design: We elicited three repetitions per speaker of the complete inventory of stressed Northern Standard German monophthongs in /hVt/ context to compare the realizations of Northern Standard German vowels in trilingual speakers from Saterland and in monolingual speakers from Hanover, whose variety of Northern Standard German is representative of the larger speech community. Data and analysis: In an acoustic analysis, we compared the durational and spectral features using linear mixed effects models. The findings are interpreted with reference to the cross-linguistic vowel productions of the trilingual speakers. Findings: For the larger part, the Northern Standard German vowel productions of the trilinguals approach the productions of the monolingual speakers in terms of both durational and spectral features. In addition, the vowel productions of the trilingual speakers suggest a bidirectional interaction between the vowel systems of the trilinguals’ three languages. Originality: This investigation is the first to study phonetic interference in vowel production in a situation of long-term language contact involving regional trilingualism and an endangered minority language. Implications: Our findings show an orientation towards the larger speech community in the realization of vowel categories in the trilinguals’ standard language. Our study also suggests that the complete inventory needs to be studied to understand the functional constraints by which the multilingual vowel space is organized. It further suggests that a comparison of multilingual with monolingual speakers is necessary to draw conclusions on the mutual subphonemic influence of the individual vowel systems.
Reasoning Support for Mapping Revision

Finding correct semantic correspondences between heterogeneous ontologies is one of the most challenging problems in the area of semantic web technologies. As manually constructing such mappings is not feasible in realistic scenarios, a number of automatic matching tools have been developed that propose mappings based on general heuristics. As these heuristics often produce incorrect results, a manual revision is inevitable in order to guarantee the quality of generated mappings. Experiences with benchmarking matching systems revealed that the manual revision of mappings is still a very difficult problem because it has to take the semantics of the ontologies as well as interactions between mappings into account. In this article, we propose methods for supporting human experts in the task of revising automatically created mappings. In particular, we present non-standard reasoning methods for detecting and propagating implications of expert decisions on the correctness of a mapping.
Simulating the elimination of sleeping sickness with an agent-based model

Although Human African Trypanosomiasis is largely considered to be in the process of extinction today, the persistence of human and animal reservoirs, as well as the vector, necessitates a laborious elimination process. In this context, modeling could be an effective tool to evaluate the ability of different public health interventions to control the disease. Using the Cormas® system, we developed HATSim, an agent-based model capable of simulating the possible endemic evolutions of sleeping sickness and the ability of National Control Programs to eliminate the disease. This model takes into account the analysis of epidemiological, entomological, and ecological data from field studies conducted during the last decade, making it possible to predict the evolution of the disease within this area over a 5-year span. In this article, we first present HATSim according to the Overview, Design concepts, and Details (ODD) protocol that is classically used to describe agent-based models, then, in a second part, we present predictive results concerning the evolution of Human African Trypanosomiasis in the village of Lambi (Cameroon), in order to illustrate the interest of such a tool. Our results are consistent with what was observed in the field by the Cameroonian National Control Program (CNCP). Our simulations also revealed that regular screening can be sufficient, although vector control applied to all areas with human activities could be significantly more efficient. Our results indicate that the current model can already help decision-makers in planning the elimination of the disease in foci.
Offspring from Mouse Embryos Developed Using a Simple Incubator-Free Culture System with a Deoxidizing Agent

To culture preimplantation embryos in vitro, water-jacketed CO2 incubators are used widely for maintaining an optimal culture environment in terms of gas phase, temperature and humidity. We investigated the possibility of mouse embryo culture in a plastic bag kept at 37°C. Zygotes derived from in vitro fertilization or collected from naturally mated B6D2F1 female mice were put in a drop of medium on a plastic culture dish and then placed in a commercially available plastic bag. When these were placed in an oven under air at 37°C for 96 h, the rate of blastocyst development and the cell numbers of embryos decreased. However, when the concentration of O2 was reduced to 5% using a deoxidizing agent and a small oxygen meter, most zygotes developed into blastocysts. These blastocysts were judged normal according to their cell number, Oct3/4 and Cdx2 gene expression levels, the apoptosis rate and the potential for full-term development after embryo transfer to pseudopregnant recipients. Furthermore, using this system, normal offspring were obtained simply by keeping the bag on a warming plate. This culture method was applied successfully to both hybrid and inbred strains. In addition, because the developing embryos could be observed through the transparent wall of the bag, it was possible to capture time-lapse images of live embryos until the blastocyst stage without needing an expensive microscope-based incubation chamber. These results suggest that mouse zygotes are more resilient to their environment than generally believed. This method might prove useful in economical culture systems or for the international shipment of embryos.
Human health and occupational exposure to pesticides among smallholder farmers in cotton zones of Côte d'Ivoire

While precautionary efforts are being made to minimize human health problems associated with agricultural pesticides, the continued occurrence of occupational poisoning from these chemicals raises major concerns among stake- holders. Information gap on human health problems associated with pesticides poses major obstacles to making informed policy decisions, particularly in developing countries where most of the poisonings occurs. In this study, we identified acute human health symptoms associated with pesticide use in cotton zone of Cote d’Ivoire and, documented the response of rural households to the symptoms. The results show that cotton farmers in Cote d’Ivoire suffer from different occupational health hazards from exposure to agricultural pesticides. Key health symptoms reported by pesticide applicators are headache, rheum, cough, skin rash and sneezing. Pesticide applicators reported four times higher symptoms of ill health than other household members who do not normally handle pesticides. Although, households recognized pesticides as an important cause of ill health, some of the symptoms have been accepted as norm by individuals who apply pesticides. Official data on pesticide poisoning in the country is most likely to be seriously under-estimated as applicators visited formal health centers for medical assistance in only 2% of poisoning cases reported. There is a high likelihood that households in the study area under-estimated pesticide-related health costs in making farm production decision-making. Approaches to use economic instruments for reliable monitoring and reporting procedures to formulate appropriate policies and regulations to minimize exposure to pesticides are recommended. Health planners and policy makers should aim at reducing the risks posed by pesticide to farm households by, improving awareness of farmers; promote complementary approach (e.g. Integrated Pest Management) and, use of economic instruments and improved surveillance to bridge the gap in the documentation of pesticide poisoning cases among farmers.
CD4 Recovery on Antiretroviral Therapy Is Associated With Decreased Progression to Liver Disease Among Hepatitis C Virus-Infected Injecting Drug Users

Background. Human immunodeficiency virus (HIV) coinfection accelerates liver disease progression in individuals with chronic hepatitis C. We evaluated the associations of CD4, HIV RNA, and antiretroviral therapy (ART)-induced CD4 recovery with liver diagnoses in a prospective cohort of injecting drug users (IDUs). Methods. We evaluated 383 coinfected IDUs in the Boston area, prospectively observed for a median of 1.8 years. Liver disease progression included the first occurrence of hepatocellular carcinoma, variceal bleeding, ascites, encephalopathy, or death due to hepatic failure. Multivariable-adjusted extended Cox models were specified to estimate hazard ratios (HRs) for comparisons of CD4, change in CD4 (from nadir), and HIV RNA with respect to liver disease progression events. Results. Twenty-four persons experienced a liver disease progression event over 1155 person-years (2.1 per 100 person-years), including 20 deaths attributed to end-stage liver disease (1.7 per 100 person-years). CD4 at baseline and over follow-up strongly predicted liver disease progression (baseline CD4 <200 vs ≥200: HR = 5.23, 95% confidence interval [CI], 2.30–11.92; time-updated CD4 <200 vs ≥200: HR = 11.79, 95% CI, 4.47–31.07). Nadir CD4 was also a strong indicator (<100 vs ≥100: HR = 3.52, 95% CI, 1.54–8.06). A lack of CD4 recovery (failure to increase 100 cells over nadir) among ART initiators was associated with increased risk (HR = 7.69; 95% CI, 2.60–22.69). Human immunodeficiency virus RNA was not significantly associated with liver disease progression. Conclusions. Impaired immune function was highly predictive of liver disease progression in this cohort of IDUs, and a lack of CD4 recovery on ART was associated with increased risk of progression to HCV-associated liver disease.
Adjunctive daily supplementation with encapsulated fruit, vegetable and berry juice powder concentrates and clinical periodontal outcomes: a double-blind RCT

Aim A double-blind randomized controlled trial to determine whether dietary supplementation with fruit/vegetable/berry juice powder concentrates, simultaneously with non-surgical periodontal therapy, improved 2-month treatment outcomes. Methods Volunteers with chronic periodontitis were randomly assigned to one of three groups: fruit/vegetable (FV), fruit/vegetable/berry (FVB) or placebo. Supplements were taken daily during non-surgical debridement and maintenance and outcomes assessed at 2, 5 and 8 months after completion. Primary outcomes were mean probing pocket depth (PPD), clinical attachment gain, % sites bleeding on probing (% BOP) at 2 months. Adherence and plasma β-carotene were determined. Results Sixty-one nutritionally replete (by serum biochemistry) volunteers enrolled and 60 (n = 20 per arm) completed the 2-month review. Clinical outcomes improved in all groups at 2 months, with additional improvement in PPD versus placebo for FV (p < 0.03). Gingival crevicular fluid volumes diminished more in supplement groups than placebo (FVB; p < 0.05) at 2 months, but not at later times. The % BOP (5 months) and cumulative plaque scores (8 months) were lowered more in the FV group (p < 0.05). Conclusions Adjunctive juice powder concentrates appear to improve initial pocket depth reductions in nutritionally replete patients, where plasma micronutrient bioavailability is attainable. Definitive multicentre studies in untreated and treated patients are required to ascertain the clinical significance of such changes.
Examining the Extent to Which Learners with Special Educational Needs are Included in Regular Schools: The Case of Four Primary Schools in Cape Town, South Africa

ABSTRACT This paper examined the nature and limit to which regular schools contain learners requiring special support in education. The study used the mixed methods approach and the post-positivist research paradigm was adopted. A sample of 80 teachers and 4 principals pooled from the four primary schools involved in the study were used to generate data. Questionnaires with closed items, interviews which are semi-structured, observations in classroom as well as documents were used to provide information. Many schools were moving towards inclusivity as established in the present study. In regular schools, there was relative prevalence of learners requiring special support in education. The study established as well, that in regular schools, learners requiring special support in education were faced with difficulties for example inadequately trained teachers, classroom shortages, class sizes, inappropriate equipment and materials. These affected the quality of access to education for these learners. Major recommendations were that schools are adequately resourced, class sizes be reduced and teachers quality be improved.
Management of Root Perforations Using MTA with or without Er:YAG Laser Irradiation: An In Vitro Study

The aim of this in vitro study is to compare the microleakage of a root perforation sealed with MTA (mineral trioxide aggregate) (group M) to that sealed with MTA following Er:YAG laser irradiation (group ML). Forty-two recently extracted human monoroot teeth were used. Two cavities were prepared on each root surface. Randomly, on each root, the exposed dentine of one cavity was irradiated prior to MTA filling using an Er:YAG laser with the following settings: 200 mJ/pulses under an air water spray, 10 Hz, pulse duration of 50 μsec, and 0.7 mm beam diameter. All cavities were then sealed with MTA. submitted to thermocycling and immersed in 2% methylene blue dye solution for 12 h. The penetration of methylene blue in the microleakage of cavity was observed and recorded. The mean value dye penetration in cavities sealed with MTA following Er:YAG laser irradiation (23.91 ± 14.63%) was lower than that of unlased cavities sealed only with MTA (25.17 ± 17.53%). No significant difference was noted. The use of an Er:YAG laser beam for dentinal conditioning prior to MTA filling of perforated roots did not decrease significantly the microleakage of MTA sealing when compared to the conventional use of MTA filling.
Assessing relationships between conformity and meta-traits in an Asch-like paradigm

Abstract The present study investigated associations between personality and conformity. Early work on this subject employed impactful, experimentally realistic procedures to induce conformity, yet lacked valid personality assessment. Conversely, contemporary work used valid personality assessment but measured conformity in low-impact settings. The present study combined the strengths of these research eras by measuring conformity in an Asch-like paradigm and testing associations with two well-validated meta-traits (Stability and Plasticity). Participants evaluated the humorousness of unfunny cartoons, either while alone (n = 103) or while surrounded by confederates who gave high scripted humorousness ratings (n = 102). Meta-traits were measured with the NEO Five Factor Inventory-3. The influence of confederates greatly increased participants’ humorousness ratings, especially among individuals higher in the meta-trait Stability.
Distributed Vibration Control Using Electrorheological Fluids

Recent developments in the smart materials technology have led to the introduction of intelligent structures that uss composite members filled with electrorheological (ER) fluids. This paper outlines the scope of the research and the role of the viscoelastic characteristics of ER materials. The shortcomings of the present models in prediction of mechanical properties of these composites are discussed. A methodology to extract the complex modulus of ER layer from modal parameters of the beam is presented. A modal modification scheme is propossd based on the discrete dynamic model of the composite beam. E electric field intensity E, elastic Young's modulus of Ih layer of sandwich beam Hi thickness of the p layer Ai cross-section area of the im layer L length of beam b width of beam &. loss factor of the ER material (2nd. layer) G material complex shear modulus = G(l+iQ x longitudinal coordinate t time variable m mass per unit length g defined shear parameter for sandwich beam Y defined geometric parameter for sandwich beam w transverse displacement of beam i square root of (-1) p modal coordinate natural frequency r damping ratio [M mass matrix [kj stiffness matrix [Cl damping matrix (II) displacement vector (fj vector of applied force [II identity matrix 4 mass normalized modal matrix () matrix transpose operation ()' " I n' derivative w.r. t. x, (n in Roman numbers) (') time derivative n non-dimensional variable (as is defined) ()' complex variable with real part () (), subscript referring to the rm mode Introductton The introduction of 'smart " composites which incorporate ER fluids, has spawnsd an emerging fisld of research that could revolutionize vibration and noise control technologies in the near future. The unique property of an ER fluid is its ability to turn into a solid gel with controllable shear modulus, when subjected to a voltage. Using this substance in a sandwiched beam or panel would give the assembfy the ability to adjust its stiffness and damping parameters. Thus, incorporating this within layers of traditional materials forms a composite, which can actively change its dynamic characteristics to modify the dynamic response of the entire structure in various conditions. when controlled using the appropriate electronics and software. The traditional viscoelastic layer solutions, are replaced by naw high performance " smart " composites with adjustable stiffness and damping factors that will provide the designer wfth the ability of employing active control schemes successfully to …
HPV16 E6 Controls the Gap Junction Protein Cx43 in Cervical Tumour Cells

Human papillomavirus type 16 (HPV16) causes a range of cancers including cervical and head and neck cancers. HPV E6 oncoprotein binds the cell polarity regulator hDlg (human homologue of Drosophila Discs Large). Previously we showed in vitro, and now in vivo, that hDlg also binds Connexin 43 (Cx43), a major component of gap junctions that mediate intercellular transfer of small molecules. In HPV16-positive non-tumour cervical epithelial cells (W12G) Cx43 localised to the plasma membrane, while in W12T tumour cells derived from these, it relocated with hDlg into the cytoplasm. We now provide evidence that E6 regulates this cytoplasmic pool of Cx43. E6 siRNA depletion in W12T cells resulted in restoration of Cx43 and hDlg trafficking to the cell membrane. In C33a HPV-negative cervical tumour cells expressing HPV16 or 18 E6, Cx43 was located primarily in the cytoplasm, but mutation of the 18E6 C-terminal hDlg binding motif resulted in redistribution of Cx43 to the membrane. The data indicate for the first time that increased cytoplasmic E6 levels associated with malignant progression alter Cx43 trafficking and recycling to the membrane and the E6/hDlg interaction may be involved. This suggests a novel E6-associated mechanism for changes in Cx43 trafficking in cervical tumour cells.
Netrin-1 Expression Is an Independent Prognostic Factor for Poor Patient Survival in Brain Metastases

The multifunctional molecule netrin-1 is upregulated in various malignancies and has recently been presented as a major general player in tumorigenesis leading to tumor progression and maintenance in various animal models. However, there is still a lack of clinico-epidemiological data related to netrin-1 expression. Therefore, the aim of our study was to elucidate the association of netrin-1 expression and patient survival in brain metastases since those constitute one of the most limiting factors for patient prognosis. We investigated 104 brain metastases cases for netrin-1 expression using in-situ hybridization and immunohistochemistry with regard to clinical parameters such as patient survival and MRI data. Our data show that netrin-1 is strongly upregulated in most cancer subtypes. Univariate analyses revealed netrin-1 expression as a significant factor associated with poor patient survival in the total cohort of brain metastasis patients and in sub-entities such as non-small cell lung carcinomas. Interestingly, many cancer samples showed a strong nuclear netrin-1 signal which was recently linked to a truncated netrin-1 variant that enhances tumor growth. Nuclear netrin-1 expression was associated with poor patient survival in univariate as well as in multivariate analyses. Our data indicate both total and nuclear netrin-1 expression as prognostic factors in brain metastases patients in contrast to other prognostic markers in oncology such as patient age, number of brain metastases or Ki67 proliferation index. Therefore, nuclear netrin-1 expression constitutes one of the first reported molecular biomarkers for patient survival in brain metastases. Furthermore, netrin-1 may constitute a promising target for future anti-cancer treatment approaches in brain metastases.
Structural change and Europe's Golden Age

Most of the countries of Western Europe grew at unprecedented rates from the late 1940s until the early 1970s. Another feature of this period was dramatic structural change, as employment shifted from agriculture to manufacturing and services. This Paper uses growth accounting to measure the direct contribution of structural change to aggregate productivity growth. The conventional accounting framework is extended and then applied to Western Europe and the USA for the period 1950-90. The Paper quantifies the importance of structural change in explaining the Golden Age, the productivity slowdown, and the cross-country variation in post-war growth rates.