Miracle-dz/UniFAR-FTUs huggingface dataset:
Induction of early-response genes KC and JE by mycobacterial lipoarabinomannans: regulation of KC expression in murine macrophages by Lsh/Ity/Bcg (candidate Nramp)

The murine chromosome 1 gene Lsh/Ity/Bcg (candidate Nramp) regulates macrophage activation for antimicrobial activity against Salmonella typhimurium, Leishmania donovani, and Mycobacterium spp. To determine early events in the activation pathway, the ability of mycobacterial lipoarabinomannan (LAM) to induce early gene (KC and JE) expression in macrophages from susceptible (S) C57BL/10ScSn (Lshs) and congenic resistant (R) B10.L-Lshr mice was investigated. Stimulation with 1.8 microgram of arabinofuranosyl-terminated LAM (AraLAM) per ml resulted in similar kinetics for KC or JE expression in S and R macrophages. However, whereas JE/glyceraldehyde 3-phosphate dehydrogenase (GAPDH) mRNA ratios remained equivalent, R macrophages consistently showed enhanced KC/GAPDH ratios within 30 to 40 min of stimulation compared with S macrophages. Significant differences in KC/GAPDH ratios were observed throughout the peak period (0.5 to 6 h) of the KC response and with doses of AraLAM ranging from 0.01 to 2.5 micrograms/ml. Heavily mannosylated LAM from virulent Mycobacterium tuberculosis Erdman, in doses of up to 2.5 micrograms/ml, failed to stimulate KC or JE in S or R macrophages. Gamma interferon alone (25 U/ml) stimulated equivalent JE expression in S and R macrophages and synergized with AraLAM to enhance JE in both. In contrast, AraLAM-induced KC expression was inhibited in the presence of gamma interferon. Agonist/inhibitor studies were undertaken to determine the signal transduction pathways mediating KC expression. The protein kinase C (PKC) inhibitor Calphostin C (200 nM) inhibited AraLAM-induced KC by 34% +/- 4% in S macrophages and 43% +/- 5% in R macrophages; the cyclic AMP-dependent PKA inhibitor KT5720 (2 microM) inhibited AraLAM-induced KC by 33% +/- 4% (S) and 25% +/- 5% (R). A role for Ca2+ was indicated because ionophore alone stimulated KC expression and synergized with AraLAM to give a dramatically enhanced response. Induction of KC was also inhibited by (i) blocking constitutive nitric oxide (NO) production by preincubation of macrophages with NG-monomethyl-L-arginine (400 microM) (48% +/- 8% [S] and 40% +/- 11% [R]) and (ii) incubation of macrophages with the cyclic GMP-dependent kinase inhibitor KT5823 (4 microM) (65% +/- 4% [S] and 72% +/- 6% [R]). The manner in which these PKC-, PKA-, and Ca(2+)-dependent, NO-mediated cyclic GMP-dependent kinase signal transduction pathways may relate to function of the candidate Lsh/Ity/Bcg gene Nramp is discussed.
Low-Volume Polyethylene Glycol Improved Patient Attendance in Bowel Preparation Before Colonoscopy: A Meta-Analysis With Trial Sequential Analysis

Background: Polyethylene glycol (PEG) has been regarded as the primary recommendation for bowel preparation before colonoscopy. However, a conclusive conclusion has not yet been generated. Aim: We performed this updated meta-analysis to further investigate the comparative efficacy and safety of low volume preparation based on PEG plus ascorbic acid related to 4L PEG. Methods: A systematic search was conducted to retrieve potential randomized controlled trials (RCTs) in PubMed, EMBASE, and Cochrane Central Register of Controlled Trials (CENTRAL) from January 2000 to April 2018. Two independent searchers critically searched all potential citations, extracted data, and appraised risk of bias accordingly. Moreover, we used the STATA 12.0 and trial sequential analysis (TSA) 0.9 to complete all analyses. Results: A total of 13 RCTs enrolling 3,910 patients met inclusion criteria. Meta-analysis based on PP analysis indicated that compared to standard volume PEG regime, low volume regime improved patient compliance RR = 1.01; 95% CIs = 1.00, 1.03; P = 0.143 (≥75% intake); RR = 1.07; 95% CIs = 1.00, 1.14; P = 0.046 (100% intake), the willingness to repeat the same regime (RR = 1.30; 95% CIs = 1.07, 157; P = 0.007), and patient acceptability (RR = 1.18; 95% CIs = 1.07, 1.29; P = 0.001), and decreased the overall adverse events (RR = 0.86; 95% CIs = 0.77, 0.96; P = 0.009). However, no difference was observed between these two different solutions for bowel preparation efficacy (RR = 0.98; 95% CIs = 0.95, 1.02; P = 0.340). These all results were further confirmed by TSA. Conclusions: The effect of low volume regime was not inferior to the standard volume PEG regime, and low volume regime was associated with better compliance when subjects ingested all the solution, willingness to repeat the same regime, higher acceptability, and lower nausea in non-selected population.
Retail banking service quality measurement: SERVQUAL gap analysis

The main objective of this paper is to present empirical findings on the quality of service offered by retail banks in South Africa. The SERVQUAL model that measure service quality based on customers' perceptions and expectations that are analysed using gap analysis. The gap analysis findings based on 184 retail banking customers shows that there is need for improvement across all five dimensions of service quality. Further inferential statistical analyses revealed that the mean gap differences among different demographic groups are statistically insignificant. These results show that to improve on service quality and reduce the negative gaps, financial institutions need to improve the overall quality of service without focusing on specific demographic groups of customers. Three of the five dimensions reliability, responsiveness, and empathy, have higher gaps compared to tangibles and assurance.
Coalition-Based Pricing in Ascending Combinatorial Auctions

Bidders in larger ascending combinatorial auctions face a substantial coordination problem, which has received little attention in the literature. The coordination problem manifests itself by the fact that losing bidders need to submit nonoverlapping package bids that are high enough to outbid the standing winners. We propose an auction format, which leverages the information that the auctioneer collects throughout the auction about the preferences of individual bidders and suggests prices for the members of losing bidder coalitions, which in total would make a given coalition winning. We model the bidder’s bundle selection problem as a coordination game, which provides a theoretical rationale for bidders to agree to these prices, and highlights the role of the auctioneer in providing relevant information feedback. Results of extensive numerical simulations and experiments with human participants demonstrate that this type of pricing substantially reduces the number of auction rounds and bids necessary to.
A Prospective Naturalistic Study of Electroconvulsive Therapy in Late-Life Depression

We performed a prospective, naturalistic study using standardized clinical rating scales to characterize the effect of electroconvulsive therapy (ECT) on mood, cognition, and medical status in late-life depression. Over a 16-month period, 40 patients aged 60 years and over who fulfilled DSM-III criteria for a major depressive episode received a total of 42 ECT courses. Three patients (7%) developed significant medical complications: one had a syncopal episode due to arrhythmia, and two had symptomatic vertebral compression fractures. Confusion was noted during 13 courses (31%) and persisted at discharge in four (10%). More than half the patients were either psychotic or demented on admission, and all but three had been either unresponsive or intolerant to pharmacotherapy. All patients experienced a decrease in their depressive symptoms and more than two thirds were in complete or partial remission at discharge. Patients with psychotic depression experienced a greater improvement than patients with nonpsychotic depression, and patients with organic mental disorders experienced the same improvement as other patients. This study confirms that ECT is a safe and effective treatment of depression in late life. (J Geriatr Psychiatry Neurol 1991; 4:3-13).
Many-body chaos near a thermal phase transition

We study many-body chaos in a (2+1)D relativistic scalar field theory at high temperatures in the classical statistical approximation, which captures the quantum critical regime and the thermal phase transition from an ordered to a disordered phase. We evaluate out-of-time ordered correlation functions (OTOCs) and find that the associated Lyapunov exponent increases linearly with temperature in the quantum critical regime, and approaches the non-interacting limit algebraically in terms of a fluctuation parameter. OTOCs spread ballistically in all regimes, also at the thermal phase transition, where the butterfly velocity is maximal. Our work contributes to the understanding of the relation between quantum and classical many-body chaos and our method can be applied to other field theories dominated by classical modes at long wavelengths.
Tracking of physical activity from childhood to adulthood.

PURPOSE To examine 1) relationships between adult PA at 35 yr and PA as a child, and 2) the influence of enhanced primary school physical education (physed+) and of parental PA upon the long-term tracking of PA in the offspring. METHODS PA data from the 1970-1977 Trois-Rivieres Growth and Development Study, completed when the children were aged 10-12 yr, were compared with PA data collected on 166 of the same subjects in 1996-1998, when aged 34.9 +/- 1.1 yr. The weekly duration of total PA, intense PA, light PA, organized PA, and total sedentary behaviors other than sleep as a child were each correlated with a questionnaire assessment of total weekly PA as an adult. RESULTS Considering males and females jointly, adult PA showed a significant but weak association with childhood PA, correlations for total PA, intense PA, light organized PA, and nonorganized PA amounting to r = 0.20, 0.18, 0.12, and 0.19, respectively. In males (N = 79), the total time spent during childhood in organized PA was associated with adult PA (r = 0.26, P < 0.05), due to students who received physed+ (r = 0.34). In females, also, a higher PA frequency as an adult was significantly associated with physed+. There was no association of PA patterns between children and their parents. CONCLUSION Our results suggest a positive impact of early required physical education upon adult PA but provide little evidence of an overall association between time spent in other categories of PA during childhood and PA as an adult.
Quantile-Based Nonparametric Inference for First-Price Auctions

We propose a quantile-based nonparametric approach to inference on the probability density function (PDF) of the private values in first-price sealed-bid auctions with independent private values. Our method of inference is based on a fully nonparametric kernel-based estimator of the quantiles and PDF of observable bids. Our estimator attains the optimal rate of Guerre, Perrigne, and Vuong (2000), and is also asymptotically normal with the appropriate choice of the bandwidth. As an application, we consider the problem of inference on the optimal reserve price.
The Effect of Combined Etiological Information on Attitudes About Mental Disorders Associated with Violent and Nonviolent Behaviors

A large body of research exists examining the associations between etiological beliefs and attitudes about mental illness. However, relatively little research has investigated the effects of portraying mental illness as a product of combined biological and psychosocial factors. Two experimental studies exposed participants to either biological, environmental, or combined etiological information about mental disorders associated with violent and nonviolent behavior. Combined etiological information increased belief in both biological and environmental causes. It also increased essentialist beliefs in one study. However, combined etiological information was not more effective at reducing stigma than other etiological information and did not interact with level of violence. Overall, causal beliefs emerged as less important to stigma than disorders' perceived associations with violence.
International Service and the Perceived Impacts on Volunteers

Although international volunteer service is growing in prevalence worldwide, there is little rigorous research about its impacts. This quasi-experimental study assesses the perceived impacts of international service on international volunteers. We focus on four internationally oriented outcome categories: international awareness, intercultural relations, international social capital, and international career intentions. International service provides exposure and immersion to develop these perspectives, relationships, and intentions. Using generalized linear mixed regression modeling, international volunteers (n = 145) are statistically more likely to report increases between the baseline (1 month before service) and postservice time periods (1 week to 1 month after service) in all outcomes except intercultural relations, as compared to a matched comparison group (n = 145). Age, race, occupational experience, and previous international experience are also associated with various outcomes. Implications include continued cultural growth, potential mutual impacts of international social capital, and future research on the volunteers and host communities.
Borrelia burgdorferi Alters Its Gene Expression and Antigenic Profile in Response to CO2 Levels

ABSTRACT The etiologic agent of Lyme disease, Borrelia burgdorferi, must adapt to the distinct environments of its arthropod vector and mammalian host during its complex life cycle. B. burgdorferi alters gene expression and protein synthesis in response to temperature, pH, and other uncharacterized environmental factors. The hypothesis tested in this study is that dissolved gases, including CO2, serve as a signal for B. burgdorferi to alter protein production and gene expression. In this study we focused on characterization of in vitro anaerobic (5% CO2, 3% H2, 0.087 ppm O2) and microaerophilic (1% CO2, 3.48 ppm O2) growth conditions and how they modulate protein synthesis and gene expression in B. burgdorferi. Higher levels of several immunoreactive proteins, including BosR, NapA, DbpA, OspC, BBK32, and RpoS, were synthesized under anaerobic conditions. Previous studies demonstrated that lower levels of NapA were produced when microaerophilic cultures were purged with nitrogen gas to displace oxygen and CO2. In this study we identified CO2 as a factor contributing to the observed change in NapA synthesis. Specifically, a reduction in the level of dissolved CO2, independent of O2 levels, resulted in reduced NapA synthesis. BosR, DbpA, OspC, and RpoS synthesis was also decreased with the displacement of CO2. Quantitative reverse transcription-PCR indicated that the levels of the dbpA, ospC, and BBK32 transcripts are increased in the presence of CO2, indicating that these putative borrelial virulence determinants are regulated at the transcriptional level. Thus, dissolved CO2 may be an additional cue for borrelial host adaptation and gene regulation.
The Role of Individual- and Macro-Level Social Determinants on Young Adolescents’ Psychosomatic Complaints

This study examines the social determinants of psychosomatic complaints in young adolescents. Using data from the Health Behaviour in School-aged Children (HBSC) study, psychosomatic complaints are studied in 98,773 adolescents (11- and 13-year-olds; 48% 11-year-olds, 52% 13-year-olds; 52% females, 48% males) from 34 European countries. Individual-level determinants, including family-, peer- and school-related factors as well as country-level determinants (Human Development Index [HDI]) are considered. In line with existing evidence, results revealed more psychosomatic complaints in young adolescents experiencing stress inducing familial-, peer- and school-related factors. Negative effects of poor friendships, negative class climate, school pressure, and high media use were more pronounced for girls. After controlling for these factors, a higher HDI was related to a lower risk for psychosomatic complaints. Gender-specific intervention programs should aim at improving the quality of relationships, especially among peers, to prevent psychosomatic complaints among young adolescents.
Machiavellianism, Locus of Control, Aggression, Performance and Precautionary Behaviour in Ice Hockey

The sport of hockey served as a setting for the investigation of the relationships between both Machiavellianism and I-E locus of control and three behavioural indices of aggression. Physical aggression, challenge to authority, and total aggression were positively related to Mach V scores and I-E locus of control, the only exception being I-E and physical aggression. Goal scoring, as a performance measure, was positively related to challenge to authority and total aggression while assists were highly correlated with all measures of aggression and I-E locus of control. Measures of precautionary behaviour were generally unrelated to the scales.
Defense Effort and Institutional Theories of Democratic Peace and Victory Why Try Harder?

Examining the relationship between regime type and defense effort provides evidence for reformulating theories of democratic peace. Consistent with liberal theories, regime type has substantively and statistically significant effects. In times of peace, democracies bear lower defense burdens than other states and keep proportionately fewer soldiers under arms. During times of war, however, democracies try harder and exert greater defense effort than non-democracies. Contrary to the results of some recent studies, all other things being equal, the arsenal of democracy appears to out-gun its opponents when it counts. Examining three components of democracy separately indicates that a largely overlooked factor, political competition, tends to drive these outcomes. Executive constraints are also associated with increased defense effort during war. But there is little evidence that wide participation or large winning coalitions have the predicted effects on defense effort. The results point to the flexible quality of defense effort in democracies, which is theoretically and empirically accounted for by the competitive political environment rather than institutional factors favored by existing theories.
Mitigating the FloodingWaves Problem in Energy-Efficient Routing for MANETs

In wireless mobile adhoc networks (MANETs) channel and energy capacities are scarce resources, a lot of energy-efficient routing protocols for MANETs have been previously proposed to take into consideration the nodes’ residual energies when establishing routes between source-destination pairs. In this paper we are not trying to introduce a new routing algorithm to be added to the already proposed stack of energy-efficient protocols, but rather, we identify a problem in cost-based energy-efficient routing for MANETs, we call this problem "Flooding Waves". We show that the "Flooding Waves" is a serious problem in dense networks, to the extent that the excessive energy overhead consumed in these waves can outweigh the gain achieved by energy-efficient path selection. We propose the "Delayed-Forwarding" as a solution for this problem. We provide both a simulation analysis and a simple theoretical framework to validate and support this solution.
A longitudinal field study of group work redesig

The paper describes an action research project on group work redesign which involved blue-collar employees in a confectionery company. A theoretical framework, derived from previous research on semi-autonomous work groups and the Job Characteristics Model modified to apply to group working (Hackman, 1977), was used as a guide to diagnosis, redesign and evaluation. Hie findings, based on a short term evaluation after six months and a longer term evaluation after eighteen months, reveal that substantial increases in group autonomy and group work identity were achieved, and were followed, as predicted, by increased work motivation, performance, job satisfaction and mental health, as well as reduced labour turnover. Of particular interest to subsequent theoretical development is the sensitivity of mental health as an outcome variable, and the existence of differential rates of change in the dependent variables.
Are most dieters unsuccessful? An alternative interpretation of the confounding of success and failure in the measurement of restraint

Since Ogden's 1993 study, the concept of restrained eating as measured by the restrained eating scale of the Dutch Eating Behaviour Questionnaire (DEBQ-R) has been further explored. In the present study, as in Ogden's study, most subjects did not differentiate between items relating to attempts at dieting and actual dieting. Ogden's conceptualization of the confounding of successful and failed restraint in the measurement of restraint, however, was not supported. First, there was no indication that trying to eat less is associated with unsuccessful dieting and actually eating less with successful dieting. Secondly, in contrast to Ogden, in our study the highest restraint score was found in subjects with low susceptibility toward failure of restraint. The results are discussed in terms of an alternative interpretation of the confounding of success and failure in the measurement of restraint. Instead of a confounding of success and failure within a subject (successful restraint is followed by failure of res.
Multimodal Behavior Program for ADHD Incorporating Yoga and Implemented by High School Volunteers: A Pilot Study

A low-cost resource approach to ADHD therapy would be a practical approach to treating children in developing countries. Research has shown that ADHD is prevalent in all areas of the world, and yet treatment for children in more impoverished countries is still lacking. The approach taken was to combine yoga and meditation combined with multimodal behavioral therapy program for children ageing 6 to 11. The program was kept low cost by using trained high school volunteers and integrating the program within the public school. After 6 weeks of the program, 90.5% of children showed improvement as measured by their performance impairment score, a measurement of academic performance. Parent and Teacher evaluations of behavior also found improvement as 25 of the 64 children (39.1%) improved into the normal range as measured by the Vanderbilt questionnaire. Moreover, children could successfully learn both yoga and meditation from high school students irrespective of their age, ADHD type, or initial performance impairment. The results demonstrate efficacy of a multimodal behavioral program incorporating yoga and meditation. The use of high school volunteers from schools in the area demonstrates an effective low-cost and universally applicable approach.
The Development of Achievement Motivation in Black and White Children.

RUHLAND, DAVID, and FELD, SHEILA. The Development of Achievement Motivation in Black and White Children. CHILD DEVELOPMENT, 1977, 48, 1362-1368. The autonomous and social comparison achievement motivation of 197 black and white children was assessed at the end of first or fourth grades and again at the end of second and fifth grades, using both level of aspiration and projective story telling measures of motivation. Black and white children were similar in their level of autonomous achievement motivation, but black children displayed lower levels of social comparison achievement motivation at both times of assessment and on both methods of measurement. Results are discussed as supportive of an educational deprivation interpretation of motivational differences rather than a cultural deprivation interpretation and as also consistent with the view of subcultural differences in the value attached to competitive individual accomplishment or cooperative achievement for attainment of group goals.