Miracle-dz/UniFAR-FTUs huggingface dataset:
Uncommon of the Uncommon: Malignant Perivascular Epithelioid Cell Tumor of the Lung

A perivascular epithelioid cell (PEC) tumor is a rare mesenchymal tumor characterized by abundant cytoplasmic Periodic acid-Schiff positive glycogen (also called sugar tumor or clear cell tumor of the lung for this characteristic) and is mostly benign. We report a case of a 63-year-old man who presented with an enlarging mass on chest radiograph. After a thorough workup, diagnosis of malignant pulmonary PEC tumor with lung to lung metastases was established. Herein, the difficulties of diagnosis and management we confronted are described.
Access constraints experienced by physically disabled students at a South African higher education institution

Abstract Current developments in government law and policies have created the hope that people living with a disability will enjoy the same rights and privileges as the non-disabled. Unfortunately, only 2.8% of disabled persons have access to higher education. The aim of this study was to determine if a group of students, living with a physical disability, experienced constraints with regard to access to a South African higher education institution. This study, following a two-phase sequential mixed method approach, consisted of a questionnaire survey, a focus group discussion, and individual interviews. It was found that students living with a physical disability experienced constraints relating to the accessibility of the relevant higher education institution. Since access constraints affect the lives of students living with a disability, it is necessary to provide guidelines to universities on how to address these challenges.
A scalable approach for statistical learning in semantic graphs

Increasingly, data is published in the form of semantic graphs. The most notable example is the Linked Open Data LOD initiative where an increasing number of data sources are published in the Semantic Web's Resource Description Framework and where the various data sources are linked to reference one another. In this paper we apply machine learning to semantic graph data and argue that scalability and robustness can be achieved via an urn-based statistical sampling scheme. We apply the urn model to the SUNS framework which is based on multivariate prediction. We argue that multivariate prediction approaches are most suitable for dealing with the resulting high-dimensional sparse data matrix. Within the statistical framework, the approach scales up to large domains and is able to deal with highly sparse relationship data. We summarize experimental results using a friend-of-a-friend data set and a data set derived from DBpedia. In more detail, we describe novel experiments on disease gene prioritization using LOD data sources. The experiments confirm the ease-of-use, the scalability and the good performance of the approach.
Cloning and spatiotemporal expression of zebrafish neuronal nicotinic acetylcholine receptor alpha 6 and alpha 4 subunit RNAs

Acetylcholine plays an important role in regulation of nervous system development and function. We are developing zebrafish (Danio rerio) as a model system to study the role of specific neuronal nicotinic acetylcholine receptor (nAChR) subtypes in development and the effects of nicotine on the developing vertebrate nervous system. We previously characterized the expression of several zebrafish nAChR subunits. To further develop the zebrafish model, here we report a study on the molecular characterization of two additional nAChR subunit genes, designated chrna6 and chrna4. Both zebrafish nAChRs have a high degree of sequence identity to nAChRs expressed in a variety of mammalian species. Reverse transcription polymerase chain reaction was used to show that both nAChR subunit RNAs were expressed early in zebrafish development, with the chrna4 transcript present at 3 hours postfertilization (hpf) and the chrna6 RNA present at 10 hpf. In situ hybridization was used to localize chrna6 and chrna4 RNA expression in 24, 48, 72, and 96 hpf zebrafish. The chrna6 and chrna4 RNAs were each expressed in a unique pattern, which changed during development. At various ages, chrna6 was expressed in Rohon‐Beard sensory neurons, trigeminal ganglion, retina, and the pineal gland. Most notably, chrna6 was expressed in catecholaminergic neurons in the midbrain, but was also present in noncatecholaminergic cells in both midbrain and hindbrain. The expression of chrna6 RNA in catecholaminergic cells supports the use of zebrafish as a valid model system to better understand the molecular basis of cholinergic regulation of dopaminergic signaling and the role of α6‐containing nAChRs in Parkinson's disease. The most notable chrna4 expression was in neural crest cells at 24 hpf and reticulospinal neurons in hindbrain at 48 hpf. chrna4 RNA exhibited a widespread and robust expression pattern in the midbrain in 72 hpf and 96 hpf zebrafish. Developmental Dynamics 238:980–992, 2009. © 2009 Wiley‐Liss, Inc.
Chagasic Cardiopathy: Demonstration of a Serum Gamma Globulin Factor Which Reacts with Endocardium and Vascular Structures

Twenty-four out of 25 patients with Chagas' heart disease have circulating immunoglobulins which react by indirect immunofluorescence technique with endocardium, interstitium and blood vessels of the heart. With skeletal muscle the reaction was observed in interstitium and vascular structures, but with other organs it was limited to vascular structures. This endocardial-vascular-interstitial factor (EVI) fixed complement. Some evidence indicated that this reaction could be obtained using the serum and tissues from the same patient: for instance, in one positive case a right atrium biopsy was performed. When this substrate was used for indirect immunofluorescence, employing the patient's own serum, positive results were obtained. Specificity is not related to AB blood group systems, or to Forssman or Wassermann antigens. The reacting factor was effectively absorbed from sera with organ homogenates, and with guinea pig red blood cells although it was independent of heterophil antibodies. In almost all cases studied, the EVI factor of the serum, when absorbed with epimastigotes of T. cruzi, results in a negative reaction, suggesting that the genesis of the reacting gamma globulin is related to antigens of T. cruzi.The EVI factor was also observed in 19 of 47 asymptomatic controls from an endemic area with positive serology for T. cruzi and in 3 of 27 with negative serology. These 3 cases had anti-T. cruzi antibodies in titers just below those considered of clinical value. The EVI factor was not observed in 119 normal individuals and 286 patients with selected cardiovascular diseases or another pathology from a nonendemic area. These findings and those mentioned above were statistically significant (P < 0.001). These results indicate the possibility of a more accurate diagnosis of chagasic myocardiopathy based on the study of the EVI factor, because in an individual case the diagnosis of chronic chagasic cardiopathy can be considered with a low probability in the absence of this factor.
Efficacy of cytotoxic agents against human tumor xenografts is markedly enhanced by coadministration of ZD1839 (Iressa), an inhibitor of EGFR tyrosine kinase.

The blockade of epidermal growth factor receptor (EGFR) function with monoclonal antibodies has major antiproliferative effects against human tumors in vivo. Similar antiproliferative effects against some of these same tumors have also been observed with specific inhibitors of the EGFR-associated tyrosine kinase. One such inhibitor, the p.o. active ZD1839 (Iressa), has pronounced antiproliferative activity against human tumor xenografts. We now show that coadministration of ZD1839, as with anti-EGFR, will enhance the efficacy of cytotoxic agents against human vulvar (A431), lung (A549 and SK-LC-16 NSCL and LX-1), and prostate (PC-3 and TSU-PR1) tumors. Oral ZD1839 (five times daily x 2) and cytotoxic agents (i.p. every 3-4 days x 4) were given for a period of 2 weeks to mice with well-established tumors. On this schedule, the maximum tolerated dose (150 mg/kg) of ZD1839 induced partial regression of A431, a tumor that expresses high levels of EGFR, 70-80% inhibition among tumors with low but highly variable levels of EGFR expression (A549, SKLC-16, TSU-PR1, and PC-3), and 50-55% inhibition against the LX-1 tumor, which expresses very low levels of EGFR. ZD1839 was very effective in potentiating most cytotoxic agents in combination treatment against all of these tumors, irrespective of EGFR status, but dose reduction of ZD1839 below its single-agent maximum tolerated dose was required for optimum tolerance. The pronounced growth inhibitory action of the platinums, cisplatin and carboplatinum, as single agents against A431 vulvar, A549 and LX-1 lung, and TSU-PR1 and PC-3 prostate tumors was increased several-fold when ZD1839 was added, with some regression of A431 and PC-3 tumors. Although the taxanes, paclitaxel or docetaxel, as single agents markedly inhibited the growth of A431, LX-1, SK-LC-16, TSU-PR1, and PC-3, when combined with ZD1839, partial or complete regression was usually seen. Against A549, the growth inhibition of doxorubicin was increased 10-fold (>99%) with ZD1839. The folate analogue, edatrexate, was highly growth inhibitory against A549, LX-1, and TSU-PR1, whereas edatrexate combined with ZD1839 resulted in partial or complete regression in these tumors. Against the A431 tumor, paclitaxel alone either was highly growth inhibitory or induced some regression, but when combined with ZD1839, pronounced regression was obtained. Combination with gemcitabine neither added nor detracted from baseline cytotoxic efficacy, whereas ZD1839 combined with vinorelbine was poorly tolerated. Overall, these results suggest that potentiation of cytotoxic treatment with ZD1839 does not require high levels of EGFR expression in the target tumors. They also suggest significant clinical benefit from ZD1839 in combination with a variety of widely used cytotoxic agents.
Job‐search assistance using the internet: experiences from a Swedish randomised experiment

This paper reports the experience from a randomised experiment offering voluntary job search assistance on the Internet to job seekers at Swedish public employment offices. Among those applying for participation, youth, highly educated and people living in big city areas were overrepresented. The evidence suggests that common difficulties inherent in the experimental approach, such as ethical concerns, bureaucratic behaviour and randomisation bias, have been circumvented. However, due to the voluntariness, the programme suffers from compliance problems in terms of both no-shows and drop-outs. The experimental intent-to-treat impact estimate fail to reject the hypothesis of a zero programme effect. Finally, a methodological comparison suggests that standard nonexperimental techniques succeed in reproducing the nonbiased experimental results.
Snow Depth Variations Estimated from GPS-Reflectometry: A Case Study in Alaska from L2P SNR Data

Snow is a water resource and plays a significant role in the water cycle. However, traditional ground techniques for snow monitoring have many limitations, e.g., high-cost and low resolution. Recently, the new Global Positioning System-Reflectometry (GPS-R) technique has been developed and applied for snow sensing. However, most previous studies mainly used GPS L1C/A and L2C Signal-to-Noise Ratio (SNR) data to retrieve snow depth. In this paper, snow depth variations are retrieved from new weak GPS L2P SNR data at three stations in Alaska and evaluated by comparing with in situ measurements. The correlation coefficients for the three stations are 0.79, 0.88 and 0.98, respectively. The GPS-estimated snow depths from the L2P SNR data are further compared with L1C/A results at three stations, showing a high correlation of 0.94, 0.93 and 0.95, respectively. These results indicate that geodetic GPS observations with SNR L2P data can well estimate snow depths. The samplings of 15 s or 30 s have no obvious effect on snow depth estimation using GPS SNR L2P measurements, while the range of 5°–35°elevation angles has effects on results with a decreasing correlation of 0.96 and RMSE of 0.04 m when compared to the range of 5°–30° with correlation of 0.98 and RMSE of 0.03 m. GPS SNR data below 30° elevation angle are better to estimate snow depth.
Bleeding Risk Index in an anticoagulation clinic. Assessment by indication and implications for care.

BACKGROUND The Outpatient Bleeding Risk Index (BRI) prospectively classified patients who were at high, intermediate, or low risk for warfarin-related major bleeding. However, there are only 2 published validation studies of the index and neither included veterans. OBJECTIVE To determine the accuracy of the BRI in patients attending a Veterans Affairs (VA) anticoagulation clinic and to specifically evaluate the accuracy of the BRI in patients with atrial fibrillation. DESIGN Retrospective cohort study. PATIENTS AND MEASUREMENTS Using the BRI, all patients managed by the Anticoagulation Clinic between January 1, 2001 and December 31, 2002 were classified as high, intermediate, or low risk for major bleeding. Bleeds were identified via quality-assurance reports. Poisson regression was used to determine whether there was an association between the index and the development of bleeding. RESULTS The rate of major bleeding was 10.6%, 2.5%, and 0.8% per patient-year of warfarin in the high-, intermediate-, and low-risk groups, respectively. Patients in the high-risk category had 14 times the rate of major bleeding of those in the low-risk group (incidence rate ratio (IRR) 14; 95% confidence interval (CI), 1.9 to 104.7). The rate of major bleeding was significantly different between the high- and intermediate-risk categories (P<.001). Among those with atrial fibrillation, patients in the high-risk category had 6 times the major bleeding rate of those in the intermediate- and low-risk groups combined (IRR=6; 95% CI, 2.4 to 15.3). CONCLUSIONS The BRI discriminates between high- and intermediate-risk patients in a VA anticoagulation clinic, including those with atrial fibrillation.
Estrogen in cycling rats alters gene expression in the temporomandibular joint, trigeminal ganglia and trigeminal subnucleus caudalis/upper cervical cord junction

Females report temporomandibular joint (TMJ) pain more than men and studies suggest estrogen modulates this pain response. Our goal in this study was to determine genes that are modulated by physiological levels of 17β‐estradiol that could have a role in TMJ pain. To complete this goal, saline or complete Freund's adjuvant was injected in the TMJ when plasma 17β‐estradiol was low or when it was at a high proestrus level. TMJ, trigeminal ganglion, and trigeminal subnucleus caudalis/upper cervical cord junction (Vc/C1–2) tissues were isolated from the treated rats and expression of 184 genes was quantitated in each tissue using real‐time PCR. Significant changes in the amount of specific transcripts were observed in the TMJ tissues, trigeminal ganglia, and Vc/C1–2 region when comparing rats with high and low estrogen. GABA A receptor subunit α6 (Gabra6) and the glycine receptor α2 (Glra2) were two genes of interest because of their direct function in neuronal activity and a >29‐fold increase in the trigeminal ganglia was observed in proestrus rats with TMJ inflammation. Immunohistochemical studies showed that Gabrα6 and Glrα2 neuronal and not glial expression increased when comparing rats with high and low estrogen. Estrogen receptors α and β are present in neurons of the trigeminal ganglia, whereby 17β‐estradiol can alter expression of Gabrα6 and Glrα2. Also, estrogen receptor α (ERα) but not ERβ was observed in satellite glial cells of the trigeminal ganglia. These results demonstrate that genes associated with neurogenic inflammation or neuronal excitability were altered by changes in the concentration of 17β‐estradiol. J. Cell. Physiol. 226: 3169–3180, 2011. © 2011 Wiley Periodicals, Inc.
Crystal structure of human cystatin C stabilized against amyloid formation

Human cystatin C (HCC) is a family 2 cystatin inhibitor of papain‐like (C1) and legumain‐related (C13) cysteine proteases. In pathophysiological processes, the nature of which is not understood, HCC is codeposited in the amyloid plaques of Alzheimer’s disease or Down’s syndrome. The amyloidogenic properties of HCC are greatly increased in a naturally occurring L68Q variant, resulting in fatal cerebral amyloid angiopathy in early adult life. In all crystal structures of cystatin C studied to date, the protein has been found to form 3D domain‐swapped dimers, created through a conformational change of a β‐hairpin loop, L1, from the papain‐binding epitope. We have created monomer‐stabilized human cystatin C, with an engineered disulfide bond (L47C)–(G69C) between the structural elements that become separated upon domain swapping. The mutant has drastically reduced dimerization and fibril formation properties, but its inhibition of papain is unaltered. The structure confirms the success of the protein engineering experiment to abolish 3D domain swapping and, in consequence, amyloid fibril formation. It illustrates for the first time the fold of monomeric cystatin C and allows verification of earlier predictions based on the domain‐swapped forms and on the structure of chicken cystatin. Importantly, the structure defines the so‐far unknown conformation of loop L1, which is essential for the inhibition of papain‐like cysteine proteases.
Creep rupture testing of alloy 617 and A508/533 base metals and weldments

The NGNP, which is an advanced HTGR concept with emphasis on both electricity and hydrogen production, involves helium as the coolant and a closed-cycle gas turbine for power generation with a core outlet/gas turbine inlet temperature of 750-1000 C. Alloy 617 is a prime candidate for VHTR structural components such as reactor internals, piping, and heat exchangers in view of its resistance to oxidation and elevated temperature strength. However, lack of adequate data on the performance of the alloy in welded condition prompted to initiate a creep test program at Argonne National Laboratory. In addition, Testing has been initiated to evaluate the creep rupture properties of the pressure vessel steel A508/533 in air and in helium environments. The program, which began in December 2009, was certified for quality assurance NQA-1 requirements during January and February 2010. Specimens were designed and fabricated during March and the tests were initiated in April 2010. During the past year, several creep tests were conducted in air on Alloy 617 base metal and weldment specimens at temperatures of 750, 850, and 950 C. Idaho National Laboratory, using gas tungsten arc welding method with Alloy 617 weld wire, fabricated the weldment specimens. Eight tests were conductedmore » on Alloy 617 base metal specimens and nine were on Alloy 617 weldments. The creep rupture times for the base alloy and weldment tests were up to {approx}3900 and {approx}4500 h, respectively. The results showed that the creep rupture lives of weld specimens are much longer than those for the base alloy, when tested under identical test conditions. The test results also showed that the creep strain at fracture is in the range of 7-18% for weldment samples and were much lower than those for the base alloy, under similar test conditions. In general, the weldment specimens showed more of a flat or constant creep rate region than the base metal specimens. The base alloy and the weldment exhibited tertiary creep after 50-60% of the rupture life, irrespective of test temperature in the range of 750-950 C. The results showed that the stress dependence of the creep rate followed a power law for both base alloy and weldments. The data also showed that the stress exponent for creep is the same and one can infer that the same mechanism is operative in both base metal and weldments in the temperature range of the current study. SEM fractography analysis indicated that both base metal and weldment showed combined fracture modes consisting of dimple rupture and intergranular cracking. Intergranular cracking was more evident in the weldment specimens, which is consistent with the observation of lower creep ductility in the weldment than in the base metal. « less
Differential Course-taking Hypothesis Revisited

In 1980 we published a report in Science which showed that differential course-taking does not account for the large sex differences in mathematical reasoning ability found among intellectually talented seventh graders. Pallas and Alexander (1983) have recently claimed that our original paper did not make clear our intention to focus on mathematical reasoning ability rather than other features of quantitative ability. We wish to point out that the abstract ("A substantial difference in mathematical reasoning ability . in favor of boys was found"), the first paragraph (three times), the methods section ("the mathematical section [of the SAT-M] is particularly designed to measure mathematical reasoning ability"), the main conclusion ("Moreover, the greatest disparity between the boys and girls is in the upper ranges of mathematical reasoning ability"), the lead paragraph of the discussion ("It is notable that we observed sizable sex differences in mathematical reasoning ability in seventh grade students"), and numerous places elsewhere throughout the paper explicitly employ the phrase mathematical reasoning ability. It is, therefore, understandable that we are puzzled by how our use of the term mathematical reasoning ability 13 times in prominent places in a 2,000 word article does not make clear our intention to focus specifically on mathematical reasoning ability. Pallas and Alexander (1983) have also suggested that our work was only an indirect test of the differential coursework hypothesis. They state that "[t]he finding that other, unspecified factors also contribute to the sex difference in quantitative performance hardly compels one to the conclusion that specialized coursework does not" (p. 4). We did not draw that conclusion. Our sole conclusion was that differential course-taking does not account for the sex differences we observed. It could not account for the differences because we showed that the boys and girls in our study had had the same amount of formal training. That is as direct as one can get.
An Investigation of Sintering Parameters on Titanium Powder for Electron Beam Melting Processing Optimization

Selective electron beam melting (SEBM) is a relatively new additive manufacturing technology for metallic materials. Specific to this technology is the sintering of the metal powder prior to the melting process. The sintering process has disadvantages for post-processing. The post-processing of parts produced by SEBM typically involves the removal of semi-sintered powder through the use of a powder blasting system. Furthermore, the sintering of large areas before melting decreases productivity. Current investigations are aimed at improving the sintering process in order to achieve better productivity, geometric accuracy, and resolution. In this study, the focus lies on the modification of the sintering process. In order to investigate and improve the sintering process, highly porous titanium test specimens with various scan speeds were built. The aim of this study was to decrease build time with comparable mechanical properties of the components and to remove the residual powder more easily after a build. By only sintering the area in which the melt pool for the components is created, an average productivity improvement of approx. 20% was achieved. Tensile tests were carried out, and the measured mechanical properties show comparatively or slightly improved values compared with the reference.