Miracle-dz/UniFAR-FTUs huggingface dataset:
PM2.5 and mortality in long-term prospective cohort studies: cause-effect or statistical associations?

Concentrations of ambient PM2.5 (particulate matter <2.5 microm in aerodynamic diameter) were associated with increased mortality in two prospective cohort studies. In this paper, I assess whether the weight of the evidence supports a causal association. I assumed the study population in each city to have the same exposure; therefore, these are ecologic studies because exposure is at the group level. Health outcome and confounding data are at the individual level. Ambient PM concentrations are inadequate surrogates for personal exposure because they are at the group level and comprise only a small proportion of personal exposure, they change over time, and they constitute only a small proportion of a life span. The strength of association and exposure-response relationships cannot be determined because the ecologic group-level risks of PM2.5 are overestimated 150- to 300-fold based on an analogy with individual-level exposure to inhaled cigarette smoke. Risk estimates may also be high because of confounding from factors such as physical activity and lung function. The evidence is not coherent because the stronger associations are expected to be with morbidity, but instead are with mortality. For example, PM2.5 was associated with mortality but not with measurable reductions in lung function. Biological plausibility is lacking because lifetime exposure of rats to combustion products at concentrations two to three orders of magnitude higher than air pollution levels cause lung overloading but no consistent reduction in survival. Criteria for quantitative risk assessment are not met so the data are not useful for setting air quality standards. The weight of evidence suggests there is no substantive basis for concluding that a cause-effect relationship exists between long-term ambient PM2.5 and increased mortality. ImagesFigure 1Figure 2Figure 3Figure 4Figure 5
Achievable Outcomes in Smooth Dynamic Contribution Games

This paper studies a class of dynamic voluntary contribution games in a setting with discounting and neoclassical payoffs (differentiable, strictly concave in the public good, and quasilinear in the private good). An achievable profile is the limit point of a subgame perfect equilibrium path -- the ultimate cumulative contribution vector of the players. A profile is shown to be achievable only if it is in the undercore of the underlying coalitional game, i.e., the profile cannot be blocked by a coalition using a component-wise smaller profile. Conversely, if free-riding incentives are strong enough that contributing zero is a dominant strategy in the stage games, then any undercore profile is the limit of achievable profiles as the period length shrinks. Thus, in this case when the period length is very short, (i) the set of achievable contributions does not depend on whether the players can move simultaneously or only in a round-robin fashion; (ii) an efficient profile can be approximately achieved if and only if it is in the core of the underlying coalitional game; and (iii) any achievable profile can be achieved almost instantly.
Money, Interest and Prices

Twenty-five years after the publication of the definitive second edition of Money, Interest, and Prices (MIP) and thirty-four years since the thirty-four year old author published the first edition, we meet to honour Don Patinkin. We will honour him most in discussing his major scientific work — its contents, its impact, and its contributions — by trying to emulate the objectivity and careful scrutiny to which Patinkin subjects the work of others.1
Investigating the relationship between social capital and self-rated health in South Africa

Much research has examined the relationship between social capital and self-rated health in developed countries. Few studies, however, have investigated this important relationship in developing countries. This study examined this research gap using data from the National Income Dynamics Study (NIDS), the first nationally representative panel study in South Africa. Information regarding social capital norms of reciprocity, association activity, trust and group membership was assessed in NIDS. Self-rated health was collected at Wave 1 in 2008, and Wave 2 in 2010 2011. The final sample consisted of 8866 respondents. Mixed effects models were fitted to predict self-rated health in Wave 2, using lagged covariates (from Wave 1). The results indicated that individual personalised trust, individual community service group membership and neighbourhood personalised trust were beneficial to self-rated health. Reciprocity, associational activity and other types of group memberships were not found to be significantly associated with self-rated health. Results indicate that both individualand contextual-level social capital are associated with self-rated health. Policy makers in South Africa may want to consider social capital, in addition to other well-known social determinants of health, when implementing policies to improve the health of its population.
Image interpretation by a single bottom-up top-down cycle

The human visual system recognizes objects and their constituent parts rapidly and with high accuracy. Standard models of recognition by the visual cortex use feed-forward processing, in which an object's parts are detected before the complete object. However, parts are often ambiguous on their own and require the prior detection and localization of the entire object. We show how a cortical-like hierarchy obtains recognition and localization of objects and parts at multiple levels nearly simultaneously by a single feed-forward sweep from low to high levels of the hierarchy, followed by a feedback sweep from high- to low-level areas.
Genome-Wide Analysis of Polycistronic MicroRNAs in Cultivated and Wild Rice

MicroRNAs (miRNAs) are small noncoding RNAs that direct posttranscriptional gene silencing in eukaryotes. They are frequently clustered in the genomes of animals and can be independently transcribed or simultaneously transcribed into single polycistronic transcripts. Only a few miRNA clusters have been described in plants, and most of them are generated from independent transcriptional units. Here, we used a combination of bioinformatic tools and experimental analyses to discover new polycistronic miRNAs in rice. A genome-wide analysis of clustering patterns of MIRNA loci in the rice genome was carried out using a criterion of 3 kb as the maximal distance between two miRNAs. This analysis revealed 28 loci with the ability to form the typical hairpin structure of miRNA precursors in which 2 or more mature miRNAs mapped along the same structure. RT-PCR provided evidence for the polycistronic nature of seven miRNA precursors containing homologous or nonhomologous miRNA species. Polycistronic miRNAs and candidate polycistronic miRNAs are located across different rice chromosomes, except chromosome 12, and resided in both duplicated and nonduplicated chromosomal regions. Finally, most polycistronic and candidate polycistronic miRNAs showed a pattern of conservation in the genome of rice species with an AA genome. The diversity in the organization of MIR genes that are transcribed as polycistrons suggests a versatile mechanism for the control of gene expression in different biological processes and supports additional levels of complexity in miRNA functioning in plants.
Evaluation of ozonesondes, HALOE, SAGE II and III, Odin- OSIRIS and -SMR, and ENVISAT-GOMOS, -SCIAMACHY and -MIPAS ozone profiles in the tropics from SAOZ long duration balloon measurements in 2003 and 2004

The performances of satellite and sondes ozone measuring instruments available in the tropics between 10 and 26 km during the southern hemisphere summer in 2003 and 2004, have been investigated by comparison with series of profiles obtained by solar occultation in the visible Chappuis bands using a SAOZ UV-Vis spectrometer carried by long duration balloons. When compared to SAOZ, systematic positive or negative altitude shifts are observed in the satellite profiles, varying from <50 m for the GOMOS v6.0b stellar occultation instrument, followed by +100/200 m for solar occultation systems (SAGE II v6.2, HALOE v19 above 22 km), but as large as −900 m for the OSIRIS limb viewing system. The ozone relative biases are generally limited, between −4% and +4%, for measurements in the visible Chappuis bands (SAGE II and SAGE III moon v3, GOMOS above 22 km and OSIRIS), the near IR (HALOE above 22 km) and the ozonesondes, but increase to +5.5% (SCIAMACHY IUP v1.63) though still in the visible, and +7% in the mid-IR (MIPAS NL v4.61) and the submillimetric range (SMR v222). Regarding precision, evaluated statistically from the zonal variability of ozone concentration, the best measurements are found to be those of SAGE II (2%), followed by HALOE above 22 km (3–4%), then the ozonesondes, SAGE III moon, SCIAMACHY and OSIRIS (4–5%), GOMOS above 22 km (~6%), MIPAS (8.5%) and finally SMR (16%). Overall, all satellite ozone measurements appear to be of little utility in the tropical troposphere except those of SAGE II (and eventually SAGE III), though low biased by 50% and of limited (50%) precision.
Molecular determinants of KATP channel inhibition by ATP

ATP‐sensitive K+ (KATP) channels are both inhibited and activated by intracellular nucleotides, such as ATP and ADP. The inhibitory effects of nucleotides are mediated via the pore‐forming subunit, Kir6.2, whereas the potentiatory effects are conferred by the sulfonylurea receptor subunit, SUR. The stimulatory action of Mg‐nucleotides complicates analysis of nucleotide inhibition of Kir6.2/SUR1 channels. We therefore used a truncated isoform of Kir6.2, that expresses ATP‐sensitive channels in the absence of SUR1, to explore the mechanism of nucleotide inhibition. We found that Kir6.2 is highly selective for ATP, and that both the adenine moiety and the β‐phosphate contribute to specificity. We also identified several mutations that significantly reduce ATP inhibition. These are located in two distinct regions of Kir6.2: the N‐terminus preceding, and the C‐terminus immediately following, the transmembrane domains. Some mutations in the C‐terminus also markedly increased the channel open probability, which may account for the decrease in apparent ATP sensitivity. Other mutations did not affect the single‐channel kinetics, and may reduce ATP inhibition by interfering with ATP binding and/or the link between ATP binding and pore closure. Our results also implicate the proximal C‐terminus in KATP channel gating.
OFDM-based turbo-coded hierarchical and non-hierarchical terrestrial mobile digital video broadcasting

The feasibility of terrestrial digital video broadcast (DVB) to mobile receivers is studied and turbo coded performance enhancements are proposed. Initially, the MPEG-2 codec is subjected to a rigorous bit error sensitivity investigation, in order to assist in designing various error protection schemes for wireless DVB transmission. The turbo codec is shown to provide signal-to-noise ratio (SNR) performance advantages in excess of 5-6 dB over conventional convolutional coding both in terms of bit error rate and video quality. Our experiments suggested that-despite our expectations-multi-class data partitioning did not result in error resilience improvements, since a high proportion of relatively sensitive video bits had to be relegated to the lower integrity subchannel, when invoking a powerful low-rate channel codec in the high-integrity protection class. Nonetheless, DVB transmission to mobile receivers is feasible, when using turbo-coded OFDM transceivers at realistic power-budget requirements under the investigated highly dispersive fading channel conditions. It is interesting to note furthermore that the 5-6 dB SNR improvement due to turbo coding allows us to invoke for example the double-throughput 16-level quadrature amplitude modulation (16-QAM) mode instead of the standard convolutional-coded 4-QAM mode. This facilitates doubling the bit rate and hence improving the video quality.
Proving properties of security protocols by induction

Informal justifications of security protocols involve arguing backwards that various events are impossible. Inductive definitions can make such arguments rigorous. The resulting proofs are complicated, but can be generated reasonably quickly using the proof tool Isabelle/HOL. There is no restriction to finite state systems and the approach is not based on belief logics. Protocols are inductively defined as sets of traces, which may involve many interleaved protocol runs. Protocol descriptions model accidental key losses as well as attacks. The model spy can send spoof messages made up of components decrypted from previous traffic. Several key distribution protocols have been studied, including Needham-Schroeder, Yahalom and Otway-Rees. The method applies to both symmetric key and public key protocols. A new attack has been discovered in a variant of Otway-Rees (already broken by W. Mao and C. Boyd (1993)). Assertions concerning secrecy and authenticity have been proved.
The labour market impact of immigration: quasi-experimental evidence

With the fall of the Berlin Wall, ethnic Germans living in the former Soviet Union and the Warsaw Pact countries were given the chance to migrate to Germany. Within 15 years, 2.8 million individuals moved. Upon arrival, these immigrants were exogenously allocated to different regions by the administration in order to ensure an even distribution across the country. Their inflows can therefore be seen as a natural experiment of immigration, avoiding the typical endogeneity problem of immigrant inflows with regard to local labour market conditions. I analyse the effect of these exogenous inflows on relative skill-specific employment and wage rates of the resident population in different geographical areas between 1996 and 2001. The variation I exploit in the empirical estimations arises primarily from differences in the initial skill composition across regions. Skill groups are defined either based on occupations or educational attainment. For both skill definitions, my results indicate a displacement effect of around 4 unemployed resident workers for every 10 immigrants that find a job. I do not find evidence of any detrimental effect on relative wages.
Modulation by Central and Basolateral Amygdalar Nuclei of Dopaminergic Correlates of Feeding to Satiety in the Rat Nucleus Accumbens and Medial Prefrontal Cortex

Current studies raise the possibility that subregions within the amygdala may interact with the mesocorticolimbic dopamine (DA) system to subserve specific psychological processes underlying food reward. The present study compared the effect of reversible inactivation of the central nucleus (CeN) versus the basolateral amygdala (BLA) on DA efflux in the nucleus accumbens (NAc) and medial prefrontal cortex (mPFC) in hungry rats that were tested in a food-devaluation procedure. During DA microdialysis experiments, lidocaine, a sodium channel blocker, was delivered via reverse dialysis into the CeN or BLA while rats were given two consecutive meals of Froot Loops. Loss of CeN function impaired the development of satiety during an initial meal and, consequently, diminished the effect of devaluation by satiety on intake of the same food during a second meal. Inactivation of the CeN was also associated with decreased basal levels of DA efflux in the NAc before food intake and attenuated increases in DA efflux related to anticipatory and consummatory aspects of feeding in both the NAc and mPFC. In contrast, inactivation of the BLA did not affect feeding behavior or DA efflux. Overall, these findings indicate that the CeN and BLA independently modulate DA transmission in both terminal regions. It is proposed that interaction between the CeN and mesocorticolimbic DA activity may be a mechanism by which hunger and satiety signals influence the value of food reward, or alternatively, a mechanism by which memory for a recently consumed food regulates food intake.
An evolutionary view on social innovation and the process of economic change

The concepts social innovation and social entrepreneurship have gained considerable attention both in different fields of academic research and in the context of the development of economic and social policies. However, despite its wide-spread use there does not exist a unique or at least widely accepted agreement among scholars on its relevance and meaning. The principal aim of this paper is to work out a general framework for the analysis of social innovations borrowing key concepts from institutional economics, evolutionary (game) theory and the capabilities approach to welfare economics. Using these approaches we specify the elements that are core for the analysis of social innovation as well as secondary elements that are in the context of this concept and specific to particular manifestations of the phenomenon. While this attempt to clarify the concept of social innovation it is necessarily incomplete, we consider it to be a first necessary step to make them more operational for empirical research in social sciences but also for the design, implementation and assessment of policies to support social innovation. The final part of the paper discusses then how social innovation contributes to social and economic progress in general, and its potential contribution to industrial change more specifically.
Diffraction-limited CCD imaging with faint reference stars

By selecting short exposure images taken using a CCD with negligible readout noise we obtained essentially diffraction-limited 810 nm images of faint objects using nearby reference stars brighter than $I=16$ at a 2.56 m telescope. The FWHM of the isoplanatic patch for the technique is found to be 50 arcseconds, providing ~20% sky coverage around suitable reference stars.
Removing Roadblocks to Success Transitions and Linkages between Home , Preschool , and Primary School

If children are to benefit from a healthy, supportive early childhood experience, it is important to strengthen transitions between early childhood experiences in educational and care settings and the more formal educational system. This issue of Coordinator's Notebook focuses on strengthening linkages and transitions between home, preschool, and primary school. The journal is divided into five sections. "Removing Roadblocks to Success: Transitions and Linkages between Home, Preschool, and Primary School" (Robert G. Myers) examines several approaches in which transitions between early childhood experiences and schooling can be supported and linkages built between home, care settings, and schools to strengthen children's ability to thrive as they move out into the world. "Diagnosis and Solutions: Efforts to Address Transitions and Linkages in Diverse Countries" (Judith L. Evans) describes activities to strengthen linkages and transitions in Kenya, Indonesia, New Zealand, the Philippines, South Africa, Guyana, Colombia, and India. "Related Resources" presents available UNICEF titles related to this topic and information available on the World Wide Web. "The New CG Secretariat: An International Exchange of ECCD (Early Childhood Care and Development) Knowledge and Experience" presents the goals and activities of the newly restructured Secretariat, a forum for regional representatives and the donor consortium to engage in knowledge gathering, synthesis and dissemination, networking, technical assistance, and early childhood care and development advocacy. "Network Notes" reports on the activities, meetings and calendar of the Secretariat and of the Partners of the Consultative Group on ECCD. (KB) lo 21,1997 Coordinators' An International Resource for Early Childhood Development U.S. DEPARTMENT OF EDUCATION Office of Educational Research and Improvement EDUCATIONAL RESOURCES INFORMATION CENTER (ERIC) This document has been reproduced as received from the person or organization originating it. Minor changes have been made to improve reproduction quality. Points of view or opinions stated in this document do not necessarily represent official OERI position or policy. PERMISSION TO REPRODUCE AND DISSEMINATE THIS MATERIAL HAS BEEN GRANTED BY
The world textile industry

This book analyzes the competitive forces which dominate this major sector, and traces how the nature of competition has evolved during the last two hundred years. Through an analysis of key factors, including demand, related and supporting industries, firm strategy, structure and national rivalry, chance and government policy, the author explains how and why the locus of competitive advantage in textiles and apparel has moved from country to country, particularly in the period since 1945.
FcRn Overexpression in Transgenic Mice Results in Augmented APC Activity and Robust Immune Response with Increased Diversity of Induced Antibodies

Our previous studies have shown that overexpression of bovine FcRn (bFcRn) in transgenic (Tg) mice leads to an increase in the humoral immune response, characterized by larger numbers of Ag-specific B cells and other immune cells in secondary lymphoid organs and higher levels of circulating Ag-specific antibodies (Abs). To gain additional insights into the mechanisms underlying this increase in humoral immune response, we further characterized the bFcRn Tg mice. Our Western blot analysis showed strong expression of the bFcRn transgene in peritoneal macrophages and bone marrow derived dendritic cells; and a quantitative PCR analysis demonstrated that the expression ratios of the bFcRn to mFcRn were 2.6- and 10-fold in these cells, respectively. We also found that overexpression of bFcRn enhances the phagocytosis of Ag-IgG immune complexes (ICs) by both macrophages and dendritic cells and significantly improves Ag presentation by dendritic cells. Finally, we determined that immunized bFcRn mice produce a much greater diversity of Ag-specific IgM, whereas only the levels, but not the diversity, of IgG is increased by overexpression of bFcRn. We suggest that the increase in diversity of IgG in Tg mice is prevented by a selective bias towards immunodominant epitopes of ovalbumin, which was used in this study as a model antigen. These results are also in line with our previous reports describing a substantial increase in the levels of Ag-specific IgG in FcRn Tg mice immunized with Ags that are weakly immunogenic and, therefore, not affected by immunodominance.
A GENERALIZATION OF THE POINCARÉ-BIRKHOFF THEOREM

A generalized form of the Poincare-Birkhoff theorem is proved. The generalization is useful for the further applications of this famous fixed point theorem. 1. Introduction and statement of the result. "To establish the existence of periodic orbits in the restricted problem of three bodies Poincare introduced his celebrated 'last geometric theorem' but was unable to prove it. A number of mathematicians had attempted to prove this theorem and at least one erroneous proof was published. Urged on by his colleagues, Birkhoff gave a beautiful proof of the theorem that went directly to the heart of the problem. Modified forms of the theorem were also presented by Birkhoff. "—quoted from Marston Morse (3). Today, this Poincare's last geometric theorem is known as the Poincare-Birkhoff theorem. In the following, we will give a statement of this theorem in modern terms.