Miracle-dz/UniFAR-FTUs huggingface dataset:
Wavelet analysis of MCG-6-30-15 and NGC 4051: a possible discovery of QPOs in 2:1 and 3:2 resonance

Following our previous work of Lachowicz & Czerny (2005), we explore further the application of the continuous wavelet transform to X-ray astronomical signals. Using the public archive of the XMM-Newton satellite, we analyze all available EPIC-pn observations for nearby Seyfert 1 galaxies MCG-6-30-15 and NGC 4051. We confine our analysis to 0.002-0.007 Hz frequency band in which, on the way of theoretically motivated premises, some quasi-periodic oscillations (QPOs) are expected to be found. We find that indeed wavelet power histogram analysis reveals such QPOs centered at two frequencies of ~2.5E-3 Hz and 4-6E-3 Hz, respectively. We show that these quasi-periodic features can be disentangled from the Poisson noise contamination level what is hardly to achieve with the standard Fourier analysis. Interestingly, we find some of them to be in 2:1 or 3:2 ratio. If real, our finding may be considered as a link between QPOs observed in AGN and kHz QPOs seen in X-ray binary systems.
Expression of gastric cancer-associated MG7 antigen in gastric cancer, precancerous lesions and H. pylori -associated gastric diseases.

AIM To investigate the relationship between the antigen MG7 antigen expression and gastric cancer as well as precancerous condition; to study the relationship between the MG7 antigen expression and H. pylori infection in benign gastric lesions in order to find out the effect of H. pylori infection on the process of gastric cancer development. METHODS The level of MG7 antigen expression was determined by immunohistochemical method in 383 gastric biopsied materials. The intestinal metaplasia was determined by histochemistry method. The H. pylori infection was determined by HE stain, PCR and ELISA in 291 specimens, among which only 34 cases of H. pylori-associated gastric lesions were followed up. RESULTS The positive rate of MG7 expression in normal gastric mucosa, intestinal metaplasia, dysplasia and gastric cancer increased gradually in ascending order (P<0.01). The positive rate of MG7 antigen expression in type III intestinal metaplasia of gastric mucosa was higher than that of type I and II intestinal metaplasia, being highly significant (P<0.05). The positive rate of MG7 antigen expression in superficial gastritis, atrophic gastritis and gastric cancer increased gradually (11.9 %, 64.8 %, 91.2 %, P<0.01). There was no significant difference between H. pylori-negative and H. pylori-positive intestinal metaplasia, atrophic gastritis and dysplasia of gastric epithelium in the positive rate of MG7 antigen expression. There was no expression of MG7 antigen in H. pylori-negative superficial gastritis. The positive rate of MG7 expression in H. pylori-positive superficial gastritis was 20.5 %, and the difference between them was significant (P<0.05). During following up, one of the three H. pylori negative cases turned positive again, and its MG7 antigen expression turned to be stronger correspondingly. 3 of 31 H. pylori positive cases were detected as early gastric cancer, among which one with "+++" MG7 antigen expression was diminished after H. pylori eradication. CONCLUSION MG7 antigen expression is highly specific in gastric cancer and can be used as a good marker for screening of gastric cancer; type III intestinal metaplasia, atrophic gastritis and dysplasia should be followed up and MG7 antigen expression has high clinical value in the dynamic follow-up study; although the positive -MG7 in positive -H. pylori superficial gastritis show benign morphology in features, there is still the potential risk of developing into gastric cancer, hence special attention should be paid to those showing increasing MG7 antigen expression.
Job and Life Satisfaction: The Perspective of Collegiate Head Coaches

Research regarding the relationship between job and life satisfaction has drawn opposing conclusions, with some suggesting one's satisfaction with work is significantly and positively related to one's attitude of life, while others claim the relationship between the two is at best weak. The purpose of this research was to further expand on the relationship between job and life satisfaction among National Collegiate Athletic Association (NCAA) head coaches. To this end, data from 348 head coaches across all three NCAA Divisions were analyzed. Results imply that life satisfaction and job satisfaction are significantly and positively related in the collegiate coaching context. However, the relationship between the two constructs was not reciprocal and the unidirectional effects differed based on the gender of the team coached. Practical implications of these findings might offer significant insights for managers and policy makers such that they are better equipped to establish and increase work (e.g., job) and non-work (e.g., life) satisfaction.
OUTCOMES OF LAPAROSCOPIC ADRENALECTOMY FOR HYPERLADOSTERONISM

Background: Primary hyperaldosteronism is a frequent cause of resistant hypertension and is amenable to surgical intervention when caused by a unilateral aldosterone‐producing adenoma. The aim of this study was to investigate the long‐term results of laparoscopic adrenalectomy in the control of hypertension caused by primary hyperaldosteronism.
Bias dependence of muon-induced single event upsets in 28 nm static random access memories

Experiments performed at TRIUMF and the Rutherford Appleton ISIS facility demonstrate the bias dependence of muon-induced single event upsets in delidded 28 nm static random access memories. Increased probability for upset is observed for memories operating at reduced voltages. Fully packaged parts are shown to be suitable to screen for low-energy muon sensitivity.
Radical remodeling of the Y chromosome in a recent radiation of malaria mosquitoes

Significance Interest in male mosquitoes has been motivated by the potential to develop novel vector control strategies, exploiting the fact that males do not feed on blood or transmit diseases, such as malaria. However, genetic studies of male Anopheles mosquitoes have been impeded by the lack of molecular characterization of the Y chromosome. Here we show that the Anopheles gambiae Y chromosome contains a very small repertoire of genes, with massively amplified tandem arrays of a small number of satellites and transposable elements constituting the vast majority of the sequence. These genes and repeats evolve rapidly, bringing about remodeling of the Y, even among closely related species. Our study provides a long-awaited foundation for studying mosquito Y chromosome biology and evolution. Y chromosomes control essential male functions in many species, including sex determination and fertility. However, because of obstacles posed by repeat-rich heterochromatin, knowledge of Y chromosome sequences is limited to a handful of model organisms, constraining our understanding of Y biology across the tree of life. Here, we leverage long single-molecule sequencing to determine the content and structure of the nonrecombining Y chromosome of the primary African malaria mosquito, Anopheles gambiae. We find that the An. gambiae Y consists almost entirely of a few massively amplified, tandemly arrayed repeats, some of which can recombine with similar repeats on the X chromosome. Sex-specific genome resequencing in a recent species radiation, the An. gambiae complex, revealed rapid sequence turnover within An. gambiae and among species. Exploiting 52 sex-specific An. gambiae RNA-Seq datasets representing all developmental stages, we identified a small repertoire of Y-linked genes that lack X gametologs and are not Y-linked in any other species except An. gambiae, with the notable exception of YG2, a candidate male-determining gene. YG2 is the only gene conserved and exclusive to the Y in all species examined, yet sequence similarity to YG2 is not detectable in the genome of a more distant mosquito relative, suggesting rapid evolution of Y chromosome genes in this highly dynamic genus of malaria vectors. The extensive characterization of the An. gambiae Y provides a long-awaited foundation for studying male mosquito biology, and will inform novel mosquito control strategies based on the manipulation of Y chromosomes.
A journey from the classroom to the world of educational reform: a study of three Korean teachers’ practitioner inquiry

Abstract This article explores three Korean teachers’ experiences of carrying out practitioner inquiry as a means of providing meaningful teaching under the test-centred schooling regime in Korea. Practitioner inquiry is a concept that includes multiple genres of educational research such as action research, teacher research, and self-study that aim to change practitioners’ individual practice and, ultimately, the schooling in a society. Based on the analysis of qualitative data, the researcher found that teachers developed their knowledge and expertise in their specific areas of interest and developed strong motivations for transforming the education system. However, their inquiry was limited in practice due to the imposition of test preparation and a prescribed national curriculum. As a result, greater collaboration among practitioners, which not just involves teachers, but wider entities such as administrators, policy makers, and researchers, is required to challenge the current unjust system.
The Impact of Isolation and Loneliness on Life Satisfaction and Depression in Community-Dwelling Elderly - The Mediating Effect of Perceived Control

본 연구는 재가노인이 지각하는 고립과 외로움이 삶의 만족도와 우울에 미치는 영향을 파악하고, 노인의 통제감의 매개효과를 검증하기 위해 D시와 K지역에 거주하는 65세 이상의 노인 435명을 대상으로 설문조사를 실시하였다. 연구 결과, 노인의 연령과 건강수준, 월소득을 통제한 후, 노인의 고립과 외로움은 삶의 만족도에 유의한 부적 영향을 미치는 것으로 나타났으며, 이 관계에서 노인의 통제감은 부분매개효과를 가지는 것으로 제시되었다. 또한, 노인의 고립과 외로움이 노인의 우울에 미치는 영향을 분석한 결과, 유의한 정적 영향을 미치는 것으로 제시되었으며, 흥미롭게도 고립과 우울과의 관계에서 통제감은 완전매개효과를 가지는 반면, 외로움과 우울과의 관계에서는 부분매개효과를 가지는 것으로 나타났다. 이러한 연구결과를 바탕으로 노인복지의 학문적, 실천적 함의 및 추후연구에 관해 제언하였다.
Procalcitonin predicts patients at low risk of death from community-acquired pneumonia across all CRB-65 classes

The aim of the present study was to investigate the prognostic value, in patients with community-acquired pneumonia (CAP), of procalcitonin (PCT) compared with the established inflammatory markers C-reactive protein (CRP) and leukocyte (WBC) count alone or in combination with the CRB-65 (confusion, respiratory rate ≥30 breaths·min−1, low blood pressure (systolic value <90 mmHg or diastolic value ≤60 mmHg) and age ≥65 yrs) score. In total, 1,671 patients with proven CAP were enrolled in the study. PCT, CRP, WBC and CRB-65 score were all determined on admission and patients were followed-up for 28 days for survival. In contrast to CRP and WBC, PCT levels markedly increased with the severity of CAP, as measured by the CRB-65 score. In 70 patients who died during follow-up, PCT levels on admission were significantly higher compared with levels in survivors. In receiver operating characteristic analysis for survival, the area under the curve (95% confidence interval) for PCT and CRB-65 was comparable (0.80 (0.75–0.84) versus 0.79 (0.74–0.84)), but each significantly higher compared with CRP (0.62 (0.54–0.68)) and WBC (0.61 (0.54–0.68)). PCT identified low-risk patients across CRB classes 0–4. In conclusion, procalcitonin levels on admission predict the severity and outcome of community-acquired pneumonia with a similar prognostic accuracy as the CRB-65 score and a higher prognostic accuracy compared with C-reactive protein and leukocyte count. Procalcitonin levels can provide independent identification of patients at low risk of death within CRB-65 (confusion, respiratory rate ≥30 breaths·min−1, low blood pressure (systolic value <90 mmHg or diastolic value ≤60 mmHg) and age ≥65 yrs) risk classes.
Power analysis attacks against FPGA implementation of KLEIN

KLEIN is a family of block ciphers proposed by Zheng Gong et al. at RFIDSec 2011, and its lightweight features are suitable for resource-constrained devices. However, the original design of KLEIN does not consider the potential attacks by power analysis methods. This paper presents power analysis attacks against a FPGA implementation of KLEIN by the authors of KLEIN. The attacking strategy, attacking point and complexity of our attacks via power analysis against KLEIN are discussed in detail. Besides, the implementation of the attacks is also described, and the experimental data is given. A lot of attacking experiments are launched by this paper, and the experiments confirm that the success probability of our attacks is nearly 100%. Finally, a defensive countermeasure against our attacks is proposed.
Randomized Controlled Trial of Social Media: Effect of Increased Intensity of the Intervention

Background A prior randomized controlled trial of social media exposure at Circulation determined that social media did not increase 30‐day page views. Whether insufficient social media intensity contributed to these results is uncertain. Methods and Results Original article manuscripts were randomized to social media exposure compared with no social media exposure (control) at Circulation beginning in January 2015. Social media exposure consisted of Facebook and Twitter posts on the journal's accounts. To increase social media intensity, a larger base of followers was built using advertising and organic growth, and posts were presented in triplicate and boosted on Facebook and retweeted on Twitter. The primary outcome was 30‐day page views. Stopping rules were established at the point that 50% of the manuscripts were randomized and had 30‐day follow‐up to compare groups on 30‐day page views. The trial was stopped for futility on September 26, 2015. Overall, 74 manuscripts were randomized to receive social media exposure, and 78 manuscripts were randomized to the control arm. The intervention and control arms were similar based on article type (P=0.85), geographic location of the corresponding author (P=0.33), and whether the manuscript had an editorial (P=0.80). Median number of 30‐day page views was 499.5 in the social media arm and 450.5 in the control arm; there was no evidence of a treatment effect (P=0.38). There were no statistically significant interactions of treatment by manuscript type (P=0.86), by corresponding author (P=0.35), by trimester of publication date (P=0.34), or by editorial status (P=0.79). Conclusions A more intensive social media strategy did not result in increased 30‐day page views of original research.
Mutants of GABA Transaminase (POP2) Suppress the Severe Phenotype of succinic semialdehyde dehydrogenase (ssadh) Mutants in Arabidopsis

BACKGROUND The gamma-aminubutyrate (GABA) shunt bypasses two steps of the tricarboxylic acid cycle, and is present in both prokaryotes and eukaryotes. In plants, the pathway is composed of the calcium/calmodulin-regulated cytosolic enzyme glutamate decarboxylase (GAD), the mitochondrial enzymes GABA transaminase (GABA-T; POP2) and succinic semialdehyde dehydrogenase (SSADH). We have previously shown that compromising the function of the GABA-shunt, by disrupting the SSADH gene of Arabidopsis, causes enhanced accumulation of reactive oxygen intermediates (ROIs) and cell death in response to light and heat stress. However, to date, genetic investigations of the relationships between enzymes of the GABA shunt have not been reported. PRINCIPAL FINDINGS To elucidate the role of succinic semialdehyde (SSA), gamma-hydroxybutyrate (GHB) and GABA in the accumulation of ROIs, we combined two genetic approaches to suppress the severe phenotype of ssadh mutants. Analysis of double pop2 ssadh mutants revealed that pop2 is epistatic to ssadh. Moreover, we isolated EMS-generated mutants suppressing the phenotype of ssadh revealing two new pop2 alleles. By measuring thermoluminescence at high temperature, the peroxide contents of ssadh and pop2 mutants were evaluated, showing that only ssadh plants accumulate peroxides. In addition, pop2 ssadh seedlings are more sensitive to exogenous SSA or GHB relative to wild type, because GHB and/or SSA accumulate in these plants. SIGNIFICANCE We conclude that the lack of supply of succinate and NADH to the TCA cycle is not responsible for the oxidative stress and growth retardations of ssadh mutants. Rather, we suggest that the accumulation of SSA, GHB, or both, produced downstream of the GABA-T transamination step, is toxic to the plants, resulting in high ROI levels and impaired development.
Molecular specificity of defined types of amacrine synapse in cat retina

The inner plexiform layer of cat retina contains synaptic structures belonging to 50 or more types of “identified” neurons. To learn whether there are antigens confined to subsets of these synaptic structures, we raised monoclonal antibodies to homogenates of neural retina. Binding patterns of these antibodies were visualized by the peroxidase- antiperoxidase method and studied in serial, ultrathin sections by electron microscopy. Four antibodies stained the synaptic varicosities of certain amacrine cells. Many of the stained varicosities formed reciprocal synapses with a rod bipolar axon terminal, but only about half of the reciprocal synapses associated with a rod bipolar were stained. Other stained varicosities formed synapses with cone bipolar axons, ganglion cell dendrites, and unstained amacrine processes. The patterns were essentially the same for each antibody and were not altered by staining with the antibodies two at a time; therefore, it is likely that all four antibodies stain the same subset of synaptic structures. These patterns would be accounted for if there were staining of all the synaptic varicosities of three of the four types of identified amacrine reciprocally connected to the rod bipolar (A6, A8, A13). This localization suggests that the antigen responsible for the binding pattern is not associated with synaptic transmission. Staining is present in the inner plexiform layer during the period of synaptogenesis and consequently the antibodies are serving as markers for following the development of identified synapses in an identified neural circuit.
Effects of Age and Level of Work Experience on Occurrence of Accidents

Results of a research study on the effects of age and work experience and their interaction on the occurrence of accidents in an agro-food sector are described. Three different levels of experience and six age groups were examined. Age and work experience significantly affected frequency and seriousness of accidents. A study of these two factors jointly shows that considerably higher rates of frequency and seriousness are found for the youngest and oldest subjects with low work experience. These analyses enable us to put forward several hypotheses concerning the mechanisms in the occurrence of accidents.
Finding Congregations

Abstract The need to assess the effectiveness of faith-based social interventions is pressing. On the one hand, politicians and pundits claim that faith-based organizations are impressively successful and inexpensive. On the other hand, critics claim that faith-based organizations lack the capacity to carry out social services. However, rigorously-collected empirical data is just beginning to appear and is still in short supply, particularly congregations. In this paper, we discuss some critical methodological and conceptual problems that arise from years of academic neglect of faith-based social service provision. We demonstrate how our attempt to create a comprehensive account of congregation-based social services in Philadelphia necessitated defining even such basic terms as “congregation” and devising novel methods for identifying and gathering information from congregations.
Estimates of individual factors of the tryptophan requirement based on protein and tryptophan accretion responses to increasing tryptophan supply in broiler chickens 8 – 21 days of age

Ten diets (196 g CP and 13.0 MJ MEN/kg) with graded levels of tryptophan (Trp) between 0.9 and 2.7 g/kg were offered ad libitum to Ross broilers from day 8 – 21 post-hatch. Each diet was allocated to three pens of ten birds each. In addition to growth and feed conversion, the accretions of protein, Trp, fat, and energy were determined by comparative whole body analyses. A sigmoidal function was fitted to the data. Responses to Trp supply were nonlinear and attained plateau values (ymax) within the studied range of Trp supply. The ymax values estimated for BW gain, whole body protein gain, and Trp gain during the 14 days under study were 615, 104, and 0.87 g/bird, respectively. Based on the response in whole body protein gain, the estimated requirement was 1.9 g Trp/kg of diet or 0.15 g Trp/MJ of MEN. Estimates made from the other response criteria were similar to this value. While the protein concentration in gained BW was unaffected by Trp intake (169 g of protein per kg of gained BW), fat and energy concentrations of gained BW increased with increasing Trp supply, approaching plateau values of 146 g fat and 9.8 MJ energy per kg of gained BW. This is supposed to result from feed intake increasing with Trp supplementation. The Trp concentration in gained whole body protein (0.84 g Trp/16 g of gained N) was not significantly affected by Trp intake. As long as Trp intake was the limiting factor, 59% of supplemented Trp was transferred to gained whole body protein. During the 14 days of the study, broilers inevitably lost 87 mg Trp. This is equivalent to a daily loss of 30 mg/kg BW or a maintenance requirement of 52 mg/kg BW per day. Data determined for the individual factors may be used for future modelling of broilers' Trp requirement.
Ciliary Muscle Cell Changes During Guinea Pig Development.

PURPOSE Guinea pig ciliary muscle (CM) increases robustly in volume, length, and thickness with age. We wanted to characterize CM cells during development to determine the contributions of hypertrophy (cell size increase) and hyperplasia (cell number increase) during development. METHODS Six pigmented guinea pig eyes were collected at each of five ages: 1, 10, 20, 30, and 90 days. Refractive errors and axial lengths were determined. Eyes were temporally marked, enucleated, hemisected, and fixed. Nasal and temporal eye segments were embedded and 30-μm serial sections were collected; the two most central slides from each hemisection were analyzed with an epifluorescence microscope and Stereo Investigator software to determine normal morphologic parameters. RESULTS Refractive errors became less hyperopic (P = 0.0001) while axial lengths and CM lengths, cross-sectional areas, volumes, and cell sizes all increased linearly with log age (all P < 0.00001). Ciliary muscle cell numbers increased only during the first 20 days of life (P = 0.02). Nasal and temporal CM lengths (P = 0.07), cross-sectional areas (P = 0.18), and cell numbers (P = 0.70) were not different, but CM cell sizes were initially larger temporally and became larger nasally after age 30 days. CONCLUSIONS The mechanism of guinea pig CM cell growth during the first 90 days of life was characterized by early hyperplasia combined with hypertrophic cell growth throughout development that results in larger CM lengths, cross-sectional areas, and volumes. Nasal-temporal CM development was generally symmetric, but there was more CM hypertrophy nasally at older ages.
Silicon Mach-Zehnder modulator of extinction ratio beyond 10dB at 10.0–12.5Gbps

Silicon Mach-Zehnder modulators with reduced series resistance in lateral PN junction rib-waveguide phase shifters are characterized in eye-diagram measurements. The modulators reveal extinction ratio beyond 10dB at 10.0–12.5Gbps, approaching lithium-niobate modulators in high-speed performance.