Miracle-dz/UniFAR-FTUs huggingface dataset:
The Versatility of Autologous Fat Transplantation in Correction of Facial Deformities: A Single-Center Experience

Deformities in the craniofacial region are of great social and functional importance. Several surgical techniques have been used to treat such pathologies often with high morbidity and lacking the ability to address smaller contour defects. The minimally invasive technique of fat transplantation has evolved rapidly within the last few decades. The objective of this paper is to present the versatility and applicability of fat transplantation in a wide range of contour deformities in the craniofacial region. We share our experiences in treating 13 patients with autoimmune disorders, congenital malformations, and acquired defects. Future perspectives of fat transplantation in the field of craniofacial reconstruction are discussed.
Link analysis ranking: algorithms, theory, and experiments

The explosive growth and the widespread accessibility of the Web has led to a surge of research activity in the area of information retrieval on the World Wide Web. The seminal papers of Kleinberg [1998, 1999] and Brin and Page [1998] introduced Link Analysis Ranking, where hyperlink structures are used to determine the relative authority of a Web page and produce improved algorithms for the ranking of Web search results. In this article we work within the hubs and authorities framework defined by Kleinberg and we propose new families of algorithms. Two of the algorithms we propose use a Bayesian approach, as opposed to the usual algebraic and graph theoretic approaches. We also introduce a theoretical framework for the study of Link Analysis Ranking algorithms. The framework allows for the definition of specific properties of Link Analysis Ranking algorithms, as well as for comparing different algorithms. We study the properties of the algorithms that we define, and we provide an axiomatic characterization of the INDEGREE heuristic which ranks each node according to the number of incoming links. We conclude the article with an extensive experimental evaluation. We study the quality of the algorithms, and we examine how different structures in the graphs affect their performance.
Intraoperative assessment of sentinel lymph nodes in breast cancer

Sentinel lymph node biopsy (SLNB) reduces the morbidity of axillary clearance and is the standard of care for patients with clinically node‐negative breast cancer. The ability to analyse the sentinel node during surgery enables a decision to be made whether to proceed to full axillary clearance during primary surgery, thus avoiding a second procedure in node‐positive patients.
CG gene body DNA methylation changes and evolution of duplicated genes in cassava

Significance Plant traits exhibit variation as a result of genetic and epigenetic change. Genetic variation is used for breeding and crop improvement. Epigenetic variation, especially differences in DNA methylation, also contributes to phenotype. For example, epigenetic alleles of plant genes exist in nature, which are identical in DNA sequence, but show heritable differences in DNA methylation and gene expression. Here we present whole-genome DNA methylation patterns of the agronomically important crop cassava (Manihot esculenta), which can serve as the basis for the study of epigenetic variation in this organism. We found that recently duplicated genes have evolved different DNA methylation and expression patterns that likely contribute to important agronomic traits. DNA methylation is important for the regulation of gene expression and the silencing of transposons in plants. Here we present genome-wide methylation patterns at single-base pair resolution for cassava (Manihot esculenta, cultivar TME 7), a crop with a substantial impact in the agriculture of subtropical and tropical regions. On average, DNA methylation levels were higher in all three DNA sequence contexts (CG, CHG, and CHH, where H equals A, T, or C) than those of the most well-studied model plant Arabidopsis thaliana. As in other plants, DNA methylation was found both on transposons and in the transcribed regions (bodies) of many genes. Consistent with these patterns, at least one cassava gene copy of all of the known components of Arabidopsis DNA methylation pathways was identified. Methylation of LTR transposons (GYPSY and COPIA) was found to be unusually high compared with other types of transposons, suggesting that the control of the activity of these two types of transposons may be especially important. Analysis of duplicated gene pairs resulting from whole-genome duplication showed that gene body DNA methylation and gene expression levels have coevolved over short evolutionary time scales, reinforcing the positive relationship between gene body methylation and high levels of gene expression. Duplicated genes with the most divergent gene body methylation and expression patterns were found to have distinct biological functions and may have been under natural or human selection for cassava traits.
In vitro, antioxidant and scavenging activities of Hibiscus rosa sinensis crude extract

The objective of this study is to ascertain the potency of , Hibiscus rosa sinensis leaves extract,with 70% ethanol/ water, as potential natural antioxidant.The phytochemical screening identified the bioactive compounds of the dry extract; carbohydrates and/or glycosides, steroids and/or triterpenes, flavonoids and tannins.The total phenolic and the total flavonoids contents reached 48.4 mg catechol equivalent and 24.26 mg quercetin equivalent /g dry weight, respectively.We assayed in vitro total antioxidant capacity and reducing power of H. rosa extract (HRE), using butylated hydroxytoluene (BHT) and ascorbic acid (ASA) as references, respectively.HRE recorded two-fold stronger antioxidant capacity than that of BHT while its reducing power was less than that of ASA, with reaction time and extract concentration dependent manner. In addition we evaluated the scavenging activities of HRE for O2 •− , H2O2 and NO compared to that of butylated hydroxyanisole (BHA). BHA recorded up to (61.6%), (65.8%), and (37.3%), respectively, at 500 µg/ml. Scavenging ability of HRE was very closed to that of BHA, in case of O2 •− ( 60.4%) and NO ( 36.3%) while it was lower in case of H2O2 (48.5%). Finally, we investigate the protection effect of HRE against lipid peroxidation (LPO) and protein oxidation(PO) using Fe +3 / ascorbate oxidizing system. LPO shwed 2.5-fold increase while PO reduced 56% of –SH groups. The co-incubation of Fe +3 /ascorbate with Hibiscus extract inhibited lipid and protein oxidative damage nearly with 31%, at 500 µg/ml. So, we can conclude that the in vitro study emphasized HRE effective antioxidant and scavenging activities which may be due to its phenolics and flavonoids contents.
Human Cytomegalovirus Primase UL70 Specifically Interacts with Cellular Factor Snapin

ABSTRACT Genomic DNA synthesis is a universally conserved process for all herpesviruses, including human cytomegalovirus (HCMV). HCMV UL70 is believed to encode the primase of the DNA replication machinery, a function which requires localization in the nucleus, the site of viral DNA synthesis. No host factors that interact with UL70 have been reported. In this study, we provide the first direct evidence that UL70 specifically interacts with Snapin, a human protein that is predominantly localized in the cytoplasm and is associated with cellular vesicles. The interaction between UL70 and Snapin was identified in both the two-hybrid screen in yeast and coimmunoprecipitation in human cells. The nuclear import of UL70 was decreased in cells overexpressing Snapin and increased in cells in which the expression of Snapin was downregulated with anti-Snapin small interfering RNA (siRNA) molecules, respectively. Furthermore, viral DNA synthesis and progeny production were decreased in cells overexpressing Snapin and increased in the anti-Snapin siRNA-treated cells, respectively. In contrast, no significant difference in the nuclear level of UL70, viral DNA synthesis, and progeny production was found among the parental cells and cells that either expressed a control empty vector or were treated with control siRNA molecules that did not recognize any viral or cellular transcripts. Our results suggest that Snapin may play a key role in regulating the cellular localization of UL70 in HCMV, leading to modulation of viral DNA synthesis and progeny production.
Explicit Bounds for Entropy Concentration Under Linear Constraints

Consider the set of all sequences of n outcomes, each taking one of m values, whose frequency vectors satisfy a set of linear constraints. If m is fixed while n increases, most sequences that satisfy the constraints result in frequency vectors whose entropy approaches that of the maximum entropy vector satisfying the constraints. This well-known entropy concentration phenomenon underlies the maximum entropy method. Existing proofs of the concentration phenomenon are based on limits or asymptotics and unrealistically assume that constraints hold precisely, supporting maximum entropy inference more in principle than in practice. We present, for the first time, non-asymptotic, explicit lower bounds on n for a number of variants of the concentration result to hold to any prescribed accuracies, with the constraints holding up to any specified tolerance, considering the fact that allocations of discrete units can satisfy constraints only approximately. Again unlike earlier results, we measure concentration not by deviation from the maximum entropy value, but by the 11 and 12 distances from the maximum entropy-achieving frequency vector. One of our results holds independently of the alphabet size m and is based on a novel proof technique using the multi-dimensional Berry-Esseen theorem. We illustrate and compare our results using various detailed examples.
The triad psoriasis–obesity–adipokine profile

Psoriasis is a chronic inflammatory skin disease, often associated with overweight/obesity. The adipose tissue is a complex organ that secretes several adipokines, involved in the regulation of some metabolic processes, such as lipid metabolism, glucose homeostasis, angiogenesis, blood pressure and inflammation. In obesity, the distribution and function of adipose tissue, and the adipokine profile are altered. The unbalanced production of pro‐ and anti‐inflammatory adipokines in obesity, contributes to the development of a chronic low‐grade inflammation state, which seems to favour worsening of psoriasis lesion and a poorer response to treatment. In this review, we will debate published data concerning the current knowledge about the triad psoriasis–obesity–adipokine profile.
VLSI Block Placement With Alignment Constraints

Corner block list (CBL) is a room-based floorplan representation. In this brief, we give a sufficient and necessary condition for the feasibility of a CBL, and we also deal with alignment constraints in CBL. A method is proposed to identify topological relation between two blocks in CBL. Based on the topological relations between blocks, it is also found that a sufficient and necessary condition to judge whether or not a CBL is feasible under alignment constraints. The experimental results showed the efficiency and effectiveness of the proposed method
Verification of integer multipliers on the arithmetic bit level

One of the most severe shortcomings of currently available equivalence checkers is their inability to verify integer multipliers. In this paper, we present a bit level reverse-engineering technique that can be integrated into standard equivalence checking flows. We propose a Boolean mapping algorithm that extracts a network of half adders from the gate netlist of an addition circuit. Once the arithmetic bit level representation of the circuit is obtained, equivalence checking can be performed using simple arithmetic operations. Experimental results show the promise of our approach.
Evolution of Abdominal Wall Reconstruction: Development of a Unified Algorithm With Improved Outcomes

IntroductionVentral hernia repair (VHR) continues to evolve and now frequently includes some form of component separation (CS) for large defects. To determine the optimal technique for VHR, we evaluated our outcomes before and after we refined and simplified our algorithm for repair. MethodsOne hundred five consecutive patients undergoing VHR for large midline hernias over 9 years were examined. Patients were divided into those operated on after (group 1) and before (group 2) the institution of our simplified algorithm. Our algorithm emphasizes careful patient selection and a stepwise approach including, but not limited to, bilateral CS if appropriate, preservation of large perforators, retrorectus mesh placement as appropriate, linea alba or midline fascial closure, and vertical panniculectomy. Primary outcomes evaluated included wound infection, dehiscence, and hernia recurrence. ResultsSeventy-eight (74.3%) patients underwent repair using our algorithm (group 1), whereas 27 (25.7%) underwent repair before utilization of this algorithm (group 2). Ninety-eight (93.3%) underwent CS, whereas 7 (6.7%) underwent another form of VHR. There was no significant difference in patient age or defect size. The mean follow-up period in days for patients in group 1 and group 2 were 184.02 and 526.06, respectively (P < 0.001). Hernia recurrence in group 1 was 2.6% versus 29.6% in group 2 (P < 0.001). The incidence of wound infection in group 1 was 10.3%, whereas that in group 2 was 33.3% (P < 0.001). The rate of wound dehiscence in group 1 was 17.9% versus 25.9% in group 2 (P < 0.001). ConclusionsSimplifying and unifying our algorithm for VHR, notably with utilization of CS, has yielded improved results. Recurrence and wound healing complications using this approach are favorable compared with published outcomes.
A scheduling algorithm based on resource overcommitment in virtualization environments

In large cloud data center where the virtualization technologies are widely used, a challenging issue is how to efficiently allocate and migrate virtual resources. In this paper, we propose a novel scheduling algorithm based on resource overcommitment, as called i-porter. The main goal of i-porter algorithm is to improve the utilizations of heterogeneous physical resources in virtualization environments. Compared to the existing solutions, i-porter has the following advantages: (1) it is a two levels of architecture that can meet the scheduling requirements, whether for virtual machine building or migration; (2) it makes the layouts of the virtual machines to be consistent and improves the cost-efficacy of the whole data center. Based on a prototype implementation of i-porter, our evaluation results show that i-porter algorithm performs excellent in resource scheduling and cost savings.
Study on maintenance operations in a chord-based Peer-to-Peer session initiation protocol overlay network

Peer-to-Peer Session Initiation Protocol (P2PSIP) is a new technology being standardized in the Internet Engineering Task Force. A P2PSIP network consists of a collection of nodes organized in a peer-to-peer fashion for the purpose of enabling real-time communication using the Session Initiation Protocol (SIP). In this paper, we present experimental results obtained by running a P2PSIP prototype in PlanetLab. Our prototype uses the Chord Distributed Hash Table (DHT) to organize the P2PSIP overlay and Peer-to-Peer Protocol (P2PP) as the protocol spoken between the peers. In the experiments, the performance of the system is studied under different churn rates and using different DHT maintenance intervals.
Learning Whom to Trust with MACE

Non-expert annotation services like Amazon’s Mechanical Turk (AMT) are cheap and fast ways to evaluate systems and provide categorical annotations for training data. Unfortunately, some annotators choose bad labels in order to maximize their pay. Manual identification is tedious, so we experiment with an item-response model. It learns in an unsupervised fashion to a) identify which annotators are trustworthy and b) predict the correct underlying labels. We match performance of more complex state-of-the-art systems and perform well even under adversarial conditions. We show considerable improvements over standard baselines, both for predicted label accuracy and trustworthiness estimates. The latter can be further improved by introducing a prior on model parameters and using Variational Bayes inference. Additionally, we can achieve even higher accuracy by focusing on the instances our model is most confident in (trading in some recall), and by incorporating annotated control instances. Our system, MACE (Multi-Annotator Competence Estimation), is available for download 1 .
CD44 Promotes Intoxication by the Clostridial Iota-Family Toxins

Various pathogenic clostridia produce binary protein toxins associated with enteric diseases of humans and animals. Separate binding/translocation (B) components bind to a protein receptor on the cell surface, assemble with enzymatic (A) component(s), and mediate endocytosis of the toxin complex. Ultimately there is translocation of A component(s) from acidified endosomes into the cytosol, leading to destruction of the actin cytoskeleton. Our results revealed that CD44, a multifunctional surface protein of mammalian cells, facilitates intoxication by the iota family of clostridial binary toxins. Specific antibody against CD44 inhibited cytotoxicity of the prototypical Clostridium perfringens iota toxin. Versus CD44+ melanoma cells, those lacking CD44 bound less toxin and were dose-dependently resistant to C. perfringens iota, as well as Clostridium difficile and Clostridium spiroforme iota-like, toxins. Purified CD44 specifically interacted in vitro with iota and iota-like, but not related Clostridium botulinum C2, toxins. Furthermore, CD44 knockout mice were resistant to iota toxin lethality. Collective data reveal an important role for CD44 during intoxication by a family of clostridial binary toxins.
Pathohistological changes in endomyocardial biopsy specimens in patients with myotonic dystrophy.

BACKGROUND Endomyocardial biopsies in patients with myotonic dystrophy (MD) have, so far, shown changes such as myofibrillar degeneration, mitochondrial abnormalities, focal myocarditis, fibrosis and fatty infiltration of the myocardium and the conduction system. METHODS This study presents the results of endomyocardial biopsy in 10 patients with MD. Endomyocardial biopsy was carried out using King's bioptome. RESULTS In two patients with servere MD biopsy specimens showed changes compatible with border line myocarditis. In five patients with moderate to severe forms of MD fibrosis and fatty infiltration of the myocardium were found in addition to degenerative changes and hypertrophy of muscle fibers. Three patients with mild MD had non-specific degenerative and hypertrophic myocardial changes. The histological changes described above were present in patients without cardiological symptoms and in those with normal ECG and echocardiographic findings. Only two of the 10 patients in whom endomyocardial biopsy was done complained of fatigue and occasional palpitations while the rest were asymptomatic. One patient with focal myocarditis had ECG signs of left bundle branch block and echocardiographic evidence of reduced left ventricular contractility. Five patients with signs of endomyocardial fibrosis only had an abnormal Q wave on ECG recordings. The remaining five patients with border line myocarditis i.e. with degenerative and hypertrophic myocardial changes had normal ECG and echocardiographic findings. CONCLUSIONS These results stress the significance of endomyocardial biopsy in detecting myocardial pathologic changes in patients with MD.
Surface morphology of human aorta as revealed by the scanning electron microscope

Human aorta was prepared for scanning electron microscopy using critical point drying. The aortic surface is lined by a continuous layer of squamous endothelial cells. The luminal surface of these cells contains many microvilli or microappendages and pinocytotic vesicles. In addition, at the periphery of each cell, larger marginal appendages or microfolds are present which allow the observer to see the cell boundaries clearly. The marginal folds are superficial to the cell junctions and could be observed without any staining procedures. These observations on human aorta are generally in agreement with our findings on the rabbit and guinea pig aorta and vena cava but are in contrast to others who have reported the presence of ridges, intercellular bridges, and “hair‐like” processes on the endothelial surfaces.
Features for Phrase-Structure Reranking from Dependency Parses

Radically different approaches have been proved to be effective for phrase-structure and dependency parsers in the last decade. Here, we aim to exploit the divergence in these approaches and show the utility of features extracted from the automatic dependency parses of sentences for a discriminative phrase-structure parser. Our experiments show a significant improvement over the state-of-the-art German discriminative constituent parser.
Multiphoton autofluorescence and second-harmonic generation imaging of the ex vivo porcine eye.

PURPOSE The purpose of this work was to demonstrate the use of the combined imaging modality of multiphoton autofluorescence and second-harmonic generation (SHG) microscopy in obtaining spectrally resolved morphologic features of the cornea, limbus, conjunctiva, and sclera in whole, ex vivo porcine eyes. METHODS The 780-nm output of a femtosecond, titanium-sapphire laser was used to induce broadband autofluorescence (435-700 nm) and SHG (390 nm) from various regions of the surface of ex vivo porcine eyes. A water-immersion objective was used for convenient imaging of the curved surface of the eye. RESULTS Multiphoton autofluorescence was useful in identifying cellular structures of the different domains of the ocular surface, and the SHG signal can be used to resolve collagen organization within the cornea stroma and sclera of ex vivo porcine eyes. CONCLUSIONS Multiphoton autofluorescence and SHG microscopy have been demonstrated to be an effective technique for resolving, respectively, the cellular and collagen structures within the ocular surface of ex vivo porcine eyes. SHG imaging resolved the difference in structural orientations between corneal and sclera collagen fibers. Specifically, the corneal collagen is organized in a depth-dependent fashion, whereas the scleral collagen is randomly packed. Because this technique does not require histologic preparation procedures, it has the potential to be applied for in vivo studies with minimal disturbance to the eye.
Predictive Knowledge Discovery by Multiobjective Genetic Fuzzy Systems for Estimating Consumer Behavior Models

The paper introduces a novel problem based on causal modeling in marketing where knowledge discovery is able to provide useful results (as shown in a real-world application). The problem features (with uncertain data and available expert knowledge) and the proposed multiobjective optimization approach makes genetic fuzzy systems to be a good framework to deal with that.