Miracle-dz/UniFAR-FTUs huggingface dataset:
Perception of Community Pharmacists towards Dispensing Errors in Community Pharmacy Setting in Gondar Town, Northwest Ethiopia

Background Dispensing errors are inevitable occurrences in community pharmacies across the world. Objective This study aimed to identify the community pharmacists' perception towards dispensing errors in the community pharmacies in Gondar town, Northwest Ethiopia. Methods A cross-sectional study was conducted among 47 community pharmacists selected through convenience sampling. Data were analyzed using SPSS version 20. Descriptive statistics, Mann–Whitney U test, and Pearson's Chi-square test of independence were conducted with P ≤ 0.05 considered statistically significant. Result The majority of respondents were in the 23–28-year age group (N = 26, 55.3%) and with at least B.Pharm degree (N = 25, 53.2%). Poor prescription handwriting and similar/confusing names were perceived to be the main contributing factors while all the strategies and types of dispensing errors were highly acknowledged by the respondents. Group differences (P < 0.05) in opinions were largely due to educational level and age. Conclusion Dispensing errors were associated with prescribing quality and design of dispensary as well as dispensing procedures. Opinion differences relate to age and educational status of the respondents.
A new quinolinone from freshwater lake-derived fungus Myrothecium verrucaria

Abstract One new quinolinone, 7-hydroxy-3-methoxyviridicatin (1), along with eight known compounds (2–9) was isolated from the fungus Myrothecium verrucaria, which was collected from lake water of Chenghai, Yunnan Province, China. Their structures were elucidated by detailed analysis of spectroscopic data and comparison with related known compounds. Compounds 1 and 2 exhibited weak antibacterial activity. To the best of our knowledge, this is the first report on quinolinones (1–4) as the secondary metabolites of M. verrucaria.
Distributed aggregation for data-parallel computing: interfaces and implementations

Data-intensive applications are increasingly designed to execute on large computing clusters. Grouped aggregation is a core primitive of many distributed programming models, and it is often the most efficient available mechanism for computations such as matrix multiplication and graph traversal. Such algorithms typically require non-standard aggregations that are more sophisticated than traditional built-in database functions such as Sum and Max. As a result, the ease of programming user-defined aggregations, and the efficiency of their implementation, is of great current interest. This paper evaluates the interfaces and implementations for user-defined aggregation in several state of the art distributed computing systems: Hadoop, databases such as Oracle Parallel Server, and DryadLINQ. We show that: the degree of language integration between user-defined functions and the high-level query language has an impact on code legibility and simplicity; the choice of programming interface has a material effect on the performance of computations; some execution plans perform better than others on average; and that in order to get good performance on a variety of workloads a system must be able to select between execution plans depending on the computation. The interface and execution plan described in the MapReduce paper, and implemented by Hadoop, are found to be among the worst-performing choices.
To what extent might N2 limit dive performance in king penguins?

SUMMARY A mathematical model was used to explore if elevated levels of N2, and risk of decompression sickness (DCS), could limit dive performance (duration and depth) in king penguins (Aptenodytes patagonicus). The model allowed prediction of blood and tissue (central circulation, muscle, brain and fat) N2 tensions (PN2) based on different cardiac outputs and blood flow distributions. Estimated mixed venous PN2 agreed with values observed during forced dives in a compression chamber used to validate the assumptions of the model. During bouts of foraging dives, estimated mixed venous and tissue PN2 increased as the bout progressed. Estimated mean maximum mixed venous PN2 upon return to the surface after a dive was 4.56±0.18 atmospheres absolute (ATA; range: 4.37–4.78 ATA). This is equivalent to N2 levels causing a 50% DCS incidence in terrestrial animals of similar mass. Bout termination events were not associated with extreme mixed venous N2 levels. Fat PN2 was positively correlated with bout duration and the highest estimated fat PN2 occurred at the end of a dive bout. The model suggested that short and shallow dives occurring between dive bouts help to reduce supersaturation and thereby DCS risk. Furthermore, adipose tissue could also help reduce DCS risk during the first few dives in a bout by functioning as a sink to buffer extreme levels of N2.
Functional quantization rate and mean regularity of processes with an application to Lévy processes

We investigate the connections between the mean pathwise regularity of stochastic processes and their L^r(P)-functional quantization rates as random variables taking values in some L^p([0,T],dt)-spaces (0 < p <= r). Our main tool is the Haar basis. We then emphasize that the derived functional quantization rate may be optimal (e.g., for Brownian motion or symmetric stable processes) so that the rate is optimal as a universal upper bound. As a first application, we establish the O((log N)^{-1/2}) upper bound for general Ito processes which include multidimensional diffusions. Then, we focus on the specific family of Levy processes for which we derive a general quantization rate based on the regular variation properties of its Levy measure at 0. The case of compound Poisson processes, which appear as degenerate in the former approach, is studied specifically: we observe some rates which are between the finite-dimensional and infinite-dimensional ``usual'' rates
In Vitro Systems Toxicology Assessment of Nonflavored e-Cigarette Liquids in Primary Lung Epithelial Cells

Abstract Electronic nicotine delivery systems (ENDS) dispense nicotine by heating a solution (e-liquid) and generating an aerosol that is then inhaled by the user. ENDS have been previously reported by some as less harmful than conventional cigarettes. However, available data regarding the toxicity of ENDS devices and e-liquids are limited and further studies are needed to fully understand their biological effects. In this study, we investigated the toxicity of nonflavored e-liquids in primary human bronchial epithelial cells using a systems toxicology approach. The toxicity of e-liquids was compared to that of nicotine alone. Cells were exposed to solutions containing different proportions of propylene glycol (PG), vegetable glycerin (VG), and nicotine. The results were compared with those of exposing cells to nicotine alone. Multiparametric indicators of cellular toxicity were measured via real-time cellular analysis and high-content screening. This study was complemented by a whole transcriptome analys.
Clinical relevance of positive voltage-gated potassium channel (VGKC)-complex antibodies: experience from a tertiary referral centre

Background Voltage-gated potassium channel (VGKC)-complex antibodies can be associated with a range of immunotherapy-responsive clinical presentations including limbic encephalitis, Morvan's syndrome and acquired neuromyotonia. However, there are patients with positive levels in whom the significance is uncertain. Objective To evaluate the clinical significance associated with positive (>100 pM) VGKC-complex antibodies. Methods Over a 4-year period, 1053 samples were sent for testing of which 55 were positive. The clinical presentations, final diagnoses and responses to immunotherapies, when given, were assessed retrospectively and the likelihood of autoimmunity was categorised as definite, possible, unlikely or undetermined (modified from Zuliani et al 2012). Results Only 4 of the 32 patients with low-positive (100–400 pM) levels were considered definitely autoimmune, 3 with peripheral nerve hyperexcitability and 1 with a thymoma; 3 were given immunotherapies. Of the remaining 28 with low-positive levels, 13 (3 of whom had tumours) were considered possibly autoimmune, and 15 were unlikely or undetermined; 1 was given immunotherapy unsuccessfully. Of the 23 patients with high-positive (>400 pM) levels, 12 were given immunotherapies, 11 of whom showed a good response. 11 were considered definitely autoimmune, 10 with limbic encephalitis (antibody specificity: 5 LGI1, 1 contactin2, 2 negative, 2 untested) and 1 with a tumour. In the remaining 12, autoimmunity was considered possible (n=9; most had not received immunotherapies), or unlikely (n=3). Conclusions As antibody testing becomes more widely available, and many samples are referred from patients with less clear-cut diagnoses, it is important to assess the utility of the results. VGKC-complex antibodies in the range of 100–400 pM (0.1–0.4 nM) were considered clinically relevant in rare conditions with peripheral nerve hyperexcitability and appeared to associate with tumours (12.5%). By contrast high-positive (>400 pM; >0.4 nM) levels were considered definitely (38%) or possibly (49%) clinically relevant, but not all patients had a ‘classical’ limbic encephalitis and some did not receive immunotherapies.
Stakeholder Perceptions of the Adoption of Continuous Integration -- A Case Study

Continuous integration is an important support mechanism for fast delivery of new features. However, its adoption in industry has often been problematic, partly due to social challenges. However, there is little knowledge of the exact nature of the challenges, and how different stakeholders perceive the need for and adoption of continuous integration. In this paper, we describe how the introduction of continuous integration was perceived by different stakeholders in a R&D program at Ericsson. The case provided a rare opportunity to study the adoption of continuous integration in a large distributed organization. We interviewed 27 stakeholders and found differing perceptions of continuous integration: how suitable it is for the organization, how adoption should be organized, and whether it is possible to achieve sufficient quality through automated testing. These differences of perception were mainly consequences of the geographic distribution. Based on the case study, we propose three guidelines. First, understand that the product architecture has a significant effect on the adoption. However, do not let architectural problems keep you from implementing continuous integration. Second, give the team members sufficient time to overcome the initial learning phase in the adoption. Third, avoid centralizing competencies to individual sites, and invest in cross-site communication.
High Frequency Word Entertainment in Spoken Dialogue High Frequency Word Entertainment in Spoken Dialogue

Abstract Cognitive theories of dialogue hold that entrainment, the automatic alignment between dialogue partners at many levels of linguistic representation, is key to facilitating both production and comprehension in dialogue. In this paper we examine novel types of entrainment in two corpora—Switchboard and the Columbia Games corpus. We examine entrainment in use of high-frequency words (the most common words in the corpus), and its association with dialogue naturalness and flow, as well as with task success. Our results show that such entrainment is predictive of the perceived naturalness of dialogues and is significantly correlated with task success; in overall interaction flow, higher degrees of entrainment are associated with more overlaps and fewer interruptions.
Accelerated partial breast irradiation

Breast‐conserving surgery followed by whole‐breast radiotherapy (WBRT) has become the standard treatment for the majority of patients with early breast cancer. Whereas the indications for systemic adjuvant treatment have continuously expanded, there is a tendency to restrict postoperative radiotherapy to accelerated partial breast irradiation (APBI) instead of WBRT.
Self-Reporting of Smoking Cessation in Cardiac Patients: How Reliable Is It and Is Reliability Associated With Patient Characteristics?

Objectives:The objectives of this study were to determine the accuracy of smoking cessation self-reports by cardiac patients who participated in a smoking cessation program, and to determine which patient characteristics are associated with an inaccurate self-report during a follow-up interview 12 months after the start of the program. Methods:Smoking cessation self-reports (point prevalence abstinence) were validated against salivary cotinine levels. Using &khgr;2 analyses, patients who reported accurately being a nonsmoker were compared with those who reported inaccurately being a nonsmoker (biochemically verified as smokers) on factors the literature has indicated to be associated with inaccurate self-report in smoking. Potential predictors of inaccurate self-report of smoking (P ⩽ 0.20 in univariate analyses) were subsequently tested in a multivariate logistic regression analysis. Results:Of the 95 patients tested, almost 25% inaccurately reported having quit smoking at a cutoff of 10-ng/mL cotinine in saliva. The data show more underreporting of smoking among patients who received a face-to-face counseling intervention and among patients with an intermediate education level. There was significantly less underreporting among patients characterized as having a Type D personality. Conclusions:These findings suggest that underreporting of smoking status in cardiac patients who participate in a smoking cessation program is high, especially in those who receive intensive face-to-face counseling. Having a Type D personality seems to be a protective factor, whereas having an intermediate level of education is a risk factor for inaccurate reporting. Biochemical validation in high-risk populations is highly needed, ideally accompanied by alternative forms of verification. Optimal validation testing in smoking cessation studies of cardiac patients is difficult because of high refusal rates, no-show, and organizational difficulties.
Genetic alterations of the WT1 gene in papillary serous carcinoma of the peritoneum.

OBJECTIVE The Wilms' tumor (WT1) gene product is consistently detectable in both normal ovarian germinal epithelium and human mesothelium. Ovarian carcinomas frequently exhibit alterations in WT1 function. Papillary serous carcinoma of the peritoneum (PSCP) is believed to develop de novo from the peritoneal lining (mesothelium) of the pelvis and abdomen. The purpose of this study was to determine if genetic alterations of the WT1 gene are associated with the development of PSCP. METHODS Normal and tumor tissue specimens were retrieved from patients with stage III and IV PSCP (n = 38) and serous epithelial ovarian carcinoma (n = 38). Immunohistochemistry was performed using the anti-WT1 (C-19) antibody. Loss of heterozygosity (LOH) was performed at the WT1 locus. Clinical data were obtained and correlated with molecular findings. RESULTS Loss of normal WT1 expression was detected in 18 (51%) of 35 PSCP specimens and 18 (53%) of 34 ovarian carcinoma specimens. Six (27%) of 22 PSCP specimens and 3 (13%) of 24 ovarian carcinoma specimens had LOH at the WT1 locus (P = 0.27). Normal WT1 gene expression was maintained in 86% of tumors exhibiting LOH. Genetic alterations of the WT1 gene were not predictive of survival, nor were they associated with other clinical or molecular factors. CONCLUSIONS Genetic alterations of the WT1 gene are associated with the development of PSCP. The loss of normal WT1 gene expression is a common event in both PSCP and advanced ovarian carcinoma, likely resulting from down-regulation by other regulatory factors-not from inactivating gene mutation and subsequent allelic loss.
A role for atmospheric CO2 in preindustrial climate forcing

Complementary to measurements in Antarctic ice cores, stomatal frequency analysis of leaves of land plants preserved in peat and lake deposits can provide a proxy record of preindustrial atmospheric CO2 concentration. CO2 trends based on leaf remains of Quercus robur (English oak) from the Netherlands support the presence of significant CO2 variability during the first half of the last millennium. The amplitude of the reconstructed multidecadal fluctuations, up to 34 parts per million by volume, considerably exceeds maximum shifts measured in Antarctic ice. Inferred changes in CO2 radiative forcing are of a magnitude similar to variations ascribed to other mechanisms, particularly solar irradiance and volcanic activity, and may therefore call into question the concept of the Intergovernmental Panel on Climate Change, which assumes an insignificant role of CO2 as a preindustrial climate-forcing factor. The stomata-based CO2 trends correlate with coeval sea-surface temperature trends in the North Atlantic Ocean, suggesting the possibility of an oceanic source/sink mechanism for the recorded CO2 changes.
Differential effects of waking from non‐rapid eye movement versus rapid eye movement sleep on cardiovascular activity

The occurrence of cardiovascular events increases in the morning, and while the mechanism responsible is yet to be determined, possible contributors include surges in sympathetic activity and concurrent rises in blood pressure (BP). This study tested the hypothesis that the increase in sympathetic dominance and the surge in BP were greater when waking spontaneously from Stage 2 sleep compared with waking from rapid eye movement (REM) sleep. Twenty healthy young adults had overnight polysomnography, including electrocardiogram measurements. Spectral analysis of heart rate variability (HRV) was conducted on 2‐min blocks of stable data selected from the last 30 min of sleep and during 30 min of resting wakefulness (supine) immediately following sleep. Outputs included absolute low frequency (LF) and high frequency (HF) power, the LF/HF ratio, heart rate (HR) and BP. To investigate the effect of waking from Stage 2 or REM sleep on HRV and BP responses, two‐way analyses of variance (anovas) (Stage 2 versus REM) with repeated measures (sleep versus morning wakefulness) were performed. It was found that waking from Stage 2 sleep was associated with significant increases in HR (P = 0·002) and BP (P < 0·001), as well as a tendency towards an increase in the LF/HF ratio (P = 0·08), whereas measurements during REM sleep and subsequent wakefulness were similar (P > 0·05). The greater increase in BP and HR when waking from Stage 2 sleep compared with REM sleep suggests that in vulnerable populations, waking from Stage 2 sleep could be an adjunct risk factor of cardiovascular events during the morning period.
C7orf30 specifically associates with the large subunit of the mitochondrial ribosome and is involved in translation

In a comparative genomics study for mitochondrial ribosome-associated proteins, we identified C7orf30, the human homolog of the plant protein iojap. Gene order conservation among bacteria and the observation that iojap orthologs cannot be transferred between bacterial species predict this protein to be associated with the mitochondrial ribosome. Here, we show colocalization of C7orf30 with the large subunit of the mitochondrial ribosome using isokinetic sucrose gradient and 2D Blue Native polyacrylamide gel electrophoresis (BN-PAGE) analysis. We co-purified C7orf30 with proteins of the large subunit, and not with proteins of the small subunit, supporting interaction that is specific to the large mitoribosomal complex. Consistent with this physical association, a mitochondrial translation assay reveals negative effects of C7orf30 siRNA knock-down on mitochondrial gene expression. Based on our data we propose that C7orf30 is involved in ribosomal large subunit function. Sequencing the gene in 35 patients with impaired mitochondrial translation did not reveal disease-causing mutations in C7orf30.
Serviceability of suction caisson founded offshore structures

Suction caissons have recently been considered as a cost-effective alternative to conventional foundations for offshore met masts and wind turbines. Such foundation arrangements are suitable for applications within water up to 20 m deep. Most offshore structures have stringent serviceability limits imposed on their design dictating the allowable structural deflections and accumulated rotations throughout its operational life. This paper summarises the findings from a series of scale model tests and identifies key factors which influence the serviceability performance of an offshore structure founded on a single caisson. Tests were conducted using representative caisson models in loose sand under single-g conditions, replicating a fully drained prototype state. These experiments recorded the rotational foundation stiffness (soil–structure interaction), the evolution of foundation stiffness under cyclic loading and the accumulation of structural rotation with loading cycles. It was discovered that the caiss.
Comparative Genomics of Transcriptional Regulation in Yeasts and its Application to Identification of a Candidate Alpha-isopropylmalate Transporter

Conservation rates in non-protein-coding regions of five yeast genomes of the genus Saccharomyces were analyzed using multiple whole-genome alignments. This analysis confirmed previously shown decrease in conservation rates observed immediately upstream of the translation start point and downstream of the stop-codon. Further, there was a sharp conservation peak in the upstream regions likely related to the core promoter (-35 bp to +35 bp around TSS) and a conservation peak downstream of the stop-codon whose function is not yet clear. Regulation of leucine and methionine biosynthesis controlled by the global regulator Gcn4p and pathway-specific regulators was analyzed in detail. A candidate alpha-isopropylmalate carrier, YOR271cp, was identified based on conservation of Leu3p binding sites, analysis of ChIP-chip data, protein localization and sequence similarity.
Genetic studies on hydatidiform moles II. The origin of complete moles

An investigation of 50 histologically complete hydatidiform moles was by examining the molar tissue after termination of pregnancy. Attempts were made to study chromosomes and 11 polymorphic enzymes in the moles and in the blood of the patient and her spouse, although not all studies were possible on every case. Useful information about the origin of the mole was obtained in 28 cases. In no case was there evidence of a maternal contribution and in 14 cases a maternal contribution was definitely excluded. In 27 cases, including the 5 tested who have subsequently required treatment, the mole was homozygous for all genetic markers examined. There were 32 examples, arising in 21 moles, of loci homozygous in the mole where the male parent was known to be homozygous. There was a single example of a mole heterozygous at one proximal locus (PGM3).