Miracle-dz/UniFAR-FTUs huggingface dataset:
Value of 3D MR Lumbosacral Radiculography in the Diagnosis of Symptomatic Chemical Radiculitis

BACKGROUND AND PURPOSE: Radiologic methods for the diagnosis of chemical radiculitis associated with anular tears in the lumbar spine have been rare. Provocative diskography is one of the methods for diagnosing diskogenic chemical radiculitis but is invasive. A reliable imaging method for replacing provocative diskography and diagnosing chemical radiculitis is required. Our aim was to investigate the value of 3D MR radiculography depicted by rendering imaging in the diagnosis of symptomatic chemical radiculopathy associated with anular tears. MATERIALS AND METHODS: The study population consisted of 17 patients (age range, 32–88 years) with unilateral radiculopathy. Symptomatic chemical radiculopathy was confirmed with provocative CT diskography and/or provocative selective nerve root block for agreement of sides and levels. Through adhering to the principles of selective excitation (Proset imaging), we acquired 3D coronal FFE sequences with selective water excitation. Morphologic changes in the ipsilateral symptomatic nerve root caused by chemical radiculopathy were compared with those in the contralateral nerve root on 3D MR lumbosacral radiculography. RESULTS: Pain reproduction at the contrast-leak level during diskography (n = 4) and selective nerve root injection (n = 13) showed concordant pain in all patients. All patients with symptomatic chemical radiculopathy showed nerve root swelling in both ipsilateral levels and sides on 3D MR radiculography. The most common nerve root affected by the chemical radiculopathy was the L5 nerve root (n = 13), while the most common segment exhibiting nerve root swelling was the exit nerve root (n = 16). CONCLUSIONS: All patients with radicular leg pain caused by chemical radiculopathy showed nerve root swelling on 3D MR radiculography. We believe that in cases without mechanical nerve root compression caused by disk herniation or stenosis in the lumbar spine, nerve root swelling on 3D MR radiculography in patients with radiculopathy associated with an anular tear may be relevant in the diagnosis of symptomatic chemical radiculopathy.
Caries Risk Assessment by a Cross-sectional Discrimination Model

Although the prevalence of dental caries is continuing to decline, it still affects a majority of the US population and can be a serious problem for those afflicted. The objective of this project was to develop and perfect a model for assessment of risk of dental caries onset in children. In the first study, reported herein, a set of clinical, microbiological, biochemical, and socio-demographic variables was identified that distinguished, with an acceptable level of sensitivity and specificity, between children who had no previous caries experience and children who had high caries levels. A total of 313 children-age 12-15 years, 140 from a fluoridated community and 173 from a fluoride-deficient community-was selected on the basis of previous caries experience, either zero DMFS or high DMFS (> 6 in the fluoridated or ≥ 8 in the fluoride-deficient community). Clinical exams for DMFS, dental fluorosis, and plaque were conducted. Stimulated whole saliva was collected for analysis of mutans streptococci, lactobacilli, total viable flora, and fluoride concentration. A questionnaire was used for collection of demographic data as well as information on prior fluoride exposure, dietary habits, and oral hygiene practices. By means of discriminant analyses, with use of seven key clinical and laboratory variables, it was possible for zero-DMFS subjects to e classified correctly (specificity) in 77.6% of cases in the fluoridated community and in 86.1% of cases in the fluoride-deficient community. High-caries subjects were classified as such (sensitivity) in 79.3% and 88.1% of cases, respectively.
Effect of Food on the Pharmacokinetics of the Integrase Inhibitor Dolutegravir

ABSTRACT Healthy subjects received dolutegravir at 50 mg in a single-dose crossover study while they were in the fasted state or with low-, moderate-, or high-fat meals. Food increased dolutegravir exposure and reduced the rate of absorption. The area under the concentration-time curve from 0 h to infinity (AUC0–∞) increased by 33%, 41%, and 66% when administered with low-, moderate-, or high-fat meals, respectively, compared with fasting. This increase in dolutegravir exposure is not anticipated to impact clinical safety, and therefore dolutegravir can be taken with or without food and without regard to fat content.
Glucose Uptake in Clostridium beijerinckii NCIMB 8052 and the Solvent-Hyperproducing Mutant BA101

ABSTRACT Glucose uptake and accumulation by Clostridium beijerinckii BA101, a butanol hyperproducing mutant, were examined during various stages of growth. Glucose uptake in C. beijerinckii BA101 was repressed 20% by 2-deoxyglucose and 25% by mannose, while glucose uptake in C. beijerinckii8052 was repressed 52 and 28% by these sugars, respectively. We confirmed the presence of a phosphoenolpyruvate (PEP)-dependent phosphotransferase system (PTS) associated with cell extracts ofC. beijerinckii BA101 by glucose phosphorylation by PEP. The PTS activity associated with C. beijerinckii BA101 was 50% of that observed for C. beijerinckii 8052.C. beijerinckii BA101 also demonstrated lower PTS activity for fructose and glucitol. Glucose phosphorylation by cell extracts derived from both C. beijerinckii BA101 and 8052 was also dependent on the presence of ATP, a finding consistent with the presence of glucokinase activity in C. beijerinckii extracts. ATP-dependent glucose phosphorylation was predominant during the solventogenic stage, when PEP-dependent glucose phosphorylation was dramatically repressed. A nearly twofold-greater ATP-dependent phosphorylation rate was observed for solventogenic stage C. beijerinckii BA101 than for solventogenic stage C. beijerinckii 8052. These results suggest that C. beijerinckii BA101 is defective in PTS activity and that C. beijerinckii BA101 compensates for this defect with enhanced glucokinase activity, resulting in an ability to transport and utilize glucose during the solventogenic stage.
Small GTPase Cdc42 Is Required for Multiple Aspects of Dendritic Morphogenesis

The study of dendritic development in CNS neurons has been hampered by a lack of complex dendritic structures that can be studied in a tractable genetic system. In an effort to develop such a system, we recently characterized the highly complex dendrites of the vertical system (VS) neurons in the Drosophila visual system. Using VS neurons as a model system, we show here using loss-of-function mutations that endogenous Cdc42, a member of Rho family of small GTPases, is required for multiple aspects of dendritic morphogenesis.Cdc42-mutant VS neurons display normal complexity but increased dendritic length compared with wild type and have defects in dendrite caliber and stereotyped dendritic branch positions. Remarkably, Cdc42 mutant neurons also show a 50% reduction in dendritic spine density. These results demonstrate that Cdc42 is a regulator for multiple aspects of dendritic development.
Bandwidth allocation in BitTorrent-like VoD systems under flashcrowds

The efficiency of BitTorrent in content distribution has inspired a number of peer-to-peer (P2P) protocols for on-demand video (VoD) streaming systems (henceforth BitTorrent-like VoD systems). However, the fundamental quality-of-service (QoS) requirements of VoD (i.e. providing peers with a smooth playback continuity and a short startup delay) make the design of these systems more challenging than normal file-sharing systems. In particular, the bandwidth allocation strategy is an important aspect in the design of BitTorrent-like VoD systems, which becomes even more crucial in a scenario where a large number of peers joins in a short period of time, a phenomenon known as flashcrowd. In fact, the new joining peers all demand for content while having few or no pieces of content to offer in return yet. An unwise allocation of the limited bandwidth actually available during this phase may cause peers to experience poor QoS. In this work, we analyze the effects of a flashcrowd on the scalability of a BitTorrent-like VoD system and propose a number of mechanisms to make the bandwidth allocation in this phase more effective. In particular, we derive an upper bound for the number of peers that can be admitted in the system over time and we find that there is a trade-off between having the seeders minimize the upload of pieces already injected recently and high peer QoS. Based on the insights gained from our analysis, we devise some flashcrowd-handling algorithms for the allocation of peer bandwidth to improve peer QoS during flashcrowd. We validate the effectiveness of our proposals by means of extensive simulations.
Crushing and Fracture of Lightweight Structures

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D-form Sequences: Families of Sequences with Low Correlation Values and Large Linear Spans

Large families of binary sequences with low correlation values and large linear span are critical for spread-spectrum communication systems. The author describes a method for constructing such families from families of homogeneous functions over finite fields, satisfying certain properties. He then uses this general method to construct specific families of sequences with optimal correlations and exponentially better linear span than No sequences (No. 1988). >
Efficient video search using image queries

We study the challenges of image-based retrieval when the database consists of videos. This variation of visual search is important for a broad range of applications that require indexing video databases based on their visual contents. We present new solutions to reduce storage requirements, while at the same time improving video search quality. The video database is preprocessed to find different appearances of the same visual elements, and build robust descriptors. Compression algorithms are developed to reduce system's storage requirements. We introduce a dataset of CNN broadcasts and queries that include photos taken with mobile phones and images of objects. Our experiments include pairwise matching and retrieval scenarios. We demonstrate one order of magnitude storage reduction and search quality improvements of up to 12% in mean average precision, compared to a baseline system that does not make use of our techniques.
Shear wave induced resonance elastography of breast tumors

Shear Wave Induced Resonance Elastography (SWIRE) has been applied to confined mimicking breast tumors. These latter have been idealized as a spherical heterogeneity embedded in an homogeneous medium transmitting torsional shear waves. First, we present a theoretical model that served to verify and physically understand the resonance induction of spheres by torsional waves. Then, experimental measurements of the resonances of a spherical heterogeneity together with the corresponding eigenmode images are presented. The good correlation between theory and experiments reveals the potential of SWIRE to segment and to mechanically characterize breast tumors. The study is concluded by a discussion on the implementation of SWIRE in the context of breast cancer elastographic imaging.
Role of parenting styles in adolescent substance use: results from a Swedish longitudinal cohort study

Objective Adolescent substance use is an area of concern because early substance use is associated with a higher risk of adverse outcomes. Parenting style, defined as the general style of parenting, as well as substance-specific parenting practices may influence children's substance use behaviour. The present study aims to probe the impact of parenting style on adolescent substance use. Method A cohort of 1268 adolescents (48% girls), aged 12–13 years at baseline, from 21 junior high schools was assessed in the first semester of junior high school, and then again in the last semester of the 9th grade, 32 months later. Parenting style, operationalised as a fourfold classification of parenting styles, including established risk factors for adolescent substance use, were measured at baseline. Results Neglectful parenting style was associated with worse substance use outcomes across all substances. After adjusting for other proximal risk factors in multivariate analyses, parenting style was found to be unrelated to substance use outcomes with one exception: authoritative parenting style was associated with less frequent drinking. Association with deviant peers, delinquent behaviour, provision of alcohol by parents, and previous use of other substances were associated with substance use outcomes at follow-up. Conclusions The results of the present study indicate that parenting style may be less important for adolescent substance use outcomes than what has previously been assumed, and that association with deviant peers and delinquent behaviour may be more important for adolescent substance use outcomes than general parenting style.
Positive selection in the evolution of cancer

We hypothesize that forms of antagonistic coevolution have forged strong links between positive selection at the molecular level and increased cancer risk. By this hypothesis, evolutionary conflict between males and females, mothers and foetuses, hosts and parasites, and other parties with divergent fitness interests has led to rapid evolution of genetic systems involved in control over fertilization and cellular resources. The genes involved in such systems promote cancer risk as a secondary effect of their roles in antagonistic coevolution, which generates evolutionary disequilibrium and maladaptation. Evidence from two sources: (1) studies on specific genes, including SPANX cancer/testis antigen genes, several Y‐linked genes, the pem homebox gene, centromeric histone genes, the breast cancer gene BRCA1, the angiogenesis gene ANG, cadherin genes, cytochrome P450 genes, and viral oncogenes; and (2) large‐scale database studies of selection on different functional categories of genes, supports our hypothesis. These results have important implications for understanding the evolutionary underpinnings of cancer and the dynamics of antagonistically‐coevolving molecular systems.
Impact of Straw Mulch on Populations of Onion Thrips (Thysanoptera: Thripidae) in Onion

Abstract Development of insecticide resistance in onion thrips, Thrips tabaci Lindeman (Thysanoptera: Thripidae), populations in onion (Allium spp.) fields and the incidence of the T. tabaci transmitted Iris yellow spot virus have stimulated interest in evaluating alternative management tactics. Effects of straw mulch applied in commercial onion fields in muck areas of western New York were assessed in 2006 and 2007 as a possible onion thrips management strategy. In trials in which no insecticides were applied for thrips control, straw mulch-treated plots supported significantly lower T. tabaci populations compared with control plots. In both years, the action thresholds of one or three larvae per leaf were reached in straw mulch treatments between 7 and 14 d later than in the control. Ground predatory fauna, as evaluated by pitfall trapping, was not increased by straw mulch in 2006; however, populations of the common predatory thrips Aeolothrips fasciatus (L.) (Thysanoptera: Aeolothripidae) were significantly lower in straw mulch plots in both years. Interference of straw mulch in the pupation and emergence of T. tabaci was investigated in the lab and their emergence was reduced by 54% compared with bare soil. In the field the overall yield of onions was not affected by the straw mulch treatment; however, the presence of jumbo grade onions (>77 mm) was increased in 2006, but not in 2007. These results indicate that populations of T. tabaci adults and larvae can be significantly reduced by the use of straw mulch without compromising overall onion yield. The use of this cultural practice in an onion integrated pest management program seems promising.
KNOWLEDGE MANAGEMENT PRACTICES : ROLE OF ORGANIZATIONAL CULTURE

Today, the key global pressure on management practices is knowledge identification, creation, innovation, dissemination, and development of talent. Workforce diversity in globalized business reflects a multitude of cultural and ethnic backgrounds necessitate aligning corresponding differences in knowledge management practices. Keeping in view the theoretical and empirical importance, the present study investigates the predicting role of culture attributes (Collaboration, Formalization, Trust and Learning) with reference to knowledge management practices (Knowledge Creation). The study was carried out on purposively selected sample of 813 corporate sector employees at different managerial positions. They were administered questionnaires including Organizational culture scale (OCS) and Knowledge Management Practices Scale (KMPS). Multiple regression analysis results revealed that Collaboration, Formalization and Trust significantly predict Knowledge Management Practices. Furthermore, ANOVA showed significant difference with reference to levels of managerial positions and knowledge management process. Study limitation, future research and implications are discussed.
Clann: investigating phylogenetic information through supertree analyses

UNLABELLED Clann has been developed in order to provide methods of investigating phylogenetic information through the application of supertrees. AVAILABILITY Clann has been precompiled for Linux, Apple Macintosh and Windows operating systems and is available from http://bioinf.may. ie/software/clann. Source code is available on request from the authors. SUPPLEMENTARY INFORMATION Clann has been written in the C programming language. Source code is available on request.
Gamma oscillations mediate stimulus competition and attentional selection in a cortical network model

Simultaneous presentation of multiple stimuli can reduce the firing rates of neurons in extrastriate visual cortex below the rate elicited by a single preferred stimulus. We describe computational results suggesting how this remarkable effect may arise from strong excitatory drive to a substantial local population of fast-spiking inhibitory interneurons, which can lead to a loss of coherence in that population and thereby raise the effectiveness of inhibition. We propose that in attentional states fast-spiking interneurons may be subject to a bath of inhibition resulting from cholinergic activation of a second class of inhibitory interneurons, restoring conditions needed for gamma rhythmicity. Oscillations and coherence are emergent features, not assumptions, in our model. The gamma oscillations in turn support stimulus competition. The mechanism is a form of “oscillatory selection,” in which neural interactions change phase relationships that regulate firing rates, and attention shapes those neural interactions.
siRNA-Act1 Inhibits the Function of IL-17 on Lung Fibroblasts via the NF-κB Pathway

Background: Interleukin (IL)-17-producing T lymphocytes play a role in pulmonary fibrosis, but the possible mechanism of IL-17 on lung fibroblasts remains uncertain. Objectives: To explore the role and possible mechanism of IL-17 on lung fibroblasts. Methods: A mouse model of pulmonary fibrosis was established by intratracheal administration of 5 mg/kg bleomycin. At 14 days following bleomycin administration the pulmonary fibroblasts were isolated, cultured and identified. siRNA for activator 1 (Act1) were transfected into lung fibroblasts, which were cocultured with IL-17. The NF-κB pathway was detected for IL-17 on the lung fibroblasts. Results: IL-17R was increased significantly at 14 days in the bleomycin-induced pulmonary fibroblast model, exogenous IL-17 significantly promoted the proliferation of the pulmonary fibroblasts in primary culture and obviously increased the expression of α-smooth muscle actin and type I and type III collagen in the fibroblasts. We found that IL-17 rapidly activated the NF-κB signaling pathway through activated phosphorylated p65 and IκB, and all roles of IL-17 on lung fibroblasts were inhibited under the interference for the expression of Act1 in lung fibroblasts. Conclusion: IL-17 may directly promote the proliferation, transformation and collagen synthesis of lung fibroblasts via the NF-kB signaling pathway, which can be inhibited by the interference for the expression of Act1.
Disorganized attachment in early childhood: Meta-analysis of precursors, concomitants, and sequelae

During the past 10 years nearly 80 studies on disorganized attachment involving more than 6,000 infant–parent dyads have been carried out. The current series of meta-analyses have established the reliability and discriminant validity of disorganized infant attachment. Although disorganized attachment behavior is necessarily difficult to observe and often subtle, many researchers have managed to become reliable coders. Furthermore, disorganized attachment shows modest short- and long-term stability, in particular in middle class environments, and it is not just a concomitant of constitutional, temperamental, or physical child problems. The predictive validity of disorganized attachment is established in terms of problematic stress management, the elevated risk of externalizing problem behavior, and even the tendency of disorganized infants to show dissociative behavior later in life. In normal, middle class families, about 15% of the infants develop disorganized attachment behavior. In other social contexts and in clinical groups this percentage may become twice or even three times higher (e.g., in the case of maltreatment). Although the importance of disorganized attachment for developmental psychopathology is evident, the search for the mechanisms leading to disorganization has just started. Frightening parental behavior may play an important role but it does not seem to be the only causal factor involved in the emergence of disorganized attachment.
Immunomodulatory activities of Punarnavine, an alkaloid from Boerhaavia diffusa

The effect of Punarnavine on the immune system was studied using Balb/c mice. Intraperitoneal administration of Punarnavine (40 mg/kg body weight) was found to enhance the total WBC count on 6th day. Bone marrow cellularity and number of α-esterase positive cells were also increased by the administration of Punarnavine. Treatment of Punarnavine along with the antigen, sheep red blood cells (SRBC), produced an enhancement in the circulating antibody titer and the number of plaque forming cells (PFC) in the spleen. Maximum number of PFC was obtained on the 6th day. Punarnavine also showed enhanced proliferation of splenocytes, thymocytes and bone marrow cells both in the presence and absence of specific mitogens in vitro and in vivo. More over administration of Punarnavine significantly reduced the LPS induced elevated levels of proinflammatory cytokines such as TNF-α, IL-1β, and IL-6 in mice. These results indicate the immunomodulatory activity of Punarnavine.