Miracle-dz/UniFAR-FTUs huggingface dataset:
Meta-analysis of cognitive functioning in patients following kidney transplantation

ABSTRACT Background There is mixed evidence regarding the nature of cognitive function in patients who have undergone renal transplantation. The aim of this meta-analysis was to examine which cognitive domains are impacted following kidney transplantation and how performance compares with non-transplanted patients or healthy controls/normative data. Method A systematic search was conducted using keywords within three databases (Embase, MEDLINE and PsychINFO), yielding 458 unique studies, 10 of which met the inclusion criteria. Neuropsychological tests were grouped into nine cognitive domains and three separate analyses were undertaken within each domain: (i) within subjects pre- versus post-transplant, (ii) transplanted versus non-transplanted patients and (iii) transplanted versus healthy matched controls and standardized normative data. Results Transplanted patients showed moderate to large improvements in the domains of general cognitive status (g = 0.526), information and motor speed (g = 0.558), spatial reasoning (g = 0.376), verbal memory (g = 0.759) and visual memory (g = 0.690) when compared with their pre-operative scores. Test scores in the same five domains were significantly better in post-transplanted patients when compared with dialysis-dependant or conservatively managed chronic kidney disease patients. However, post-transplanted patients’ performance was significantly low compared with that of healthy controls (and standardized normative data) in the domains of executive functioning (g = −0.283), verbal fluency (g = −0.657) and language (g = −0.573). Conclusions Two key issues arise from this review. First, domain-specific cognitive improvement occurs in patients after successful transplantation. Nevertheless, transplanted patients still performed significantly below healthy controls in some domains. Second, there are important shortcomings in existing studies; the length of follow-up is typically short and only limited neuropsychological test batteries are employed. These factors are important in order to support the recovery of cognitive function among patients following renal transplant.
Single-exposure visual memory judgments are reflected in inferotemporal cortex

Our visual memory percepts of whether we have encountered specific objects or scenes before are hypothesized to manifest as decrements in neural responses in inferotemporal cortex (IT) with stimulus repetition. To evaluate this proposal, we recorded IT neural responses as two monkeys performed a single-exposure visual memory task designed to measure the rates of forgetting with time. We found that a weighted linear read-out of IT was a better predictor of the monkeys’ forgetting rates and reaction time patterns than a strict instantiation of the repetition suppression hypothesis, expressed as a total spike count scheme. Behavioral predictions could be attributed to visual memory signals that were reflected as repetition suppression and were intermingled with visual selectivity, but only when combined across the most sensitive neurons.
Experimental North American West Nile Virus Infection in the Red-legged Partridge (Alectoris rufa)

After the introduction of West Nile virus (WNV) into North America, bird mortalities associated with West Nile disease have dramatically increased in this continent and, to a lesser extent, in Europe. The different West Nile disease incidence in birds in these 2 continents demands an explanation, and experimental studies can provide important information. The authors inoculated thirteen 9-week-old red-legged partridges (Alectoris rufa) with 107 plaque-forming units of a WNV strain isolated in New York in 1999. The objective was to study the pathogenesis of the infection in a native Euro-Mediterranean bird species with a WNV strain known to be highly pathogenic for numerous native American bird species. Additionally, the authors evaluated the dynamics of inflammatory cell activation and recruitment into the brain. WNV was detected in tissues 3 days postinoculation (dpi), and the birds developed macroscopic and microscopic lesions. Two partridges succumbed to the disease. The most affected tissues were the heart, brain, and spinal cord. The main microscopic findings were the presence of mononuclear infiltrates in the heart and brain, gliosis, and degeneration and necrosis of cardiomyocytes and neurons. These lesions were aggravated in the birds that died or were euthanized 7 dpi or later. In the brain, there was an upregulation of microglial cells and astrocytes and an increase in the number of T cells, especially after 7 dpi. These results show that this WNV strain is of moderate virulence for the red-legged partridge and that WNV-infected red-legged partridges develop an immune cell response in the brain similar to that of mammals.
Determination of silver release from antibacterial finished cotton and polyester fabrics into water

Abstract Silver compounds have extensive use among the antimicrobial agents in textiles. Silver particles are released into the water during washing processes in particular and they are released from the textile in time due to use. In this work, silver ion release from cotton and polyester antimicrobial fabrics which are the most widely used textiles have been studied. Two well-known silver-based commercial agents and silver-doped calcium phosphate powder-based antibacterial finishing agent which was developed in our previous work were applied to the fabric samples. The release of silver from the fabric samples during washing and incubation was determined by ICP-OES. The effects of fabric composition, time and laundering process on the silver release were studied. It was found that significant amount of silver was released from textile fabrics during washing due to the mechanical forces exerted on the fabrics. The total released silver varied from 73.43 to 92.27% for cotton fabrics and 76.49 to 89.70% for PES fabrics after 20 washing cycles. Results also showed that calcium phosphate can reduce the amount of silver release significantly. It was also found that even a smaller quantity of nanosilver particles was sufficient for strong antibacterial activity.
A systematic review on phenolic compounds in Passiflora plants: Exploring biodiversity for food, nutrition, and popular medicine

ABSTRACT Passiflora plants are strategic in the context of biodiversity for food and nutrition. We applied the procedures of a systematic review protocol to study the state of the art on identification of phenolic compounds from Passiflora plants. An automated literature search was conducted using six databases and a combination of seven keywords. All the analytical, chromatographic, and spectroscopic methods were included. The studies were classified according to their method of identification, phenolic classes, and method of extraction. In total, 8,592 abstracts were found, from which 122 studies were selected for complete reading and 82 were selected for further analysis. Techniques of extraction, evaluated parts of the plant and methods of identification were systematized. Studies with leaves were most conspicuous (54.4%), 34 species of Passiflora were evaluated and orientin, isoorientin, vitexin, isovitexin were commonly found structures. A High Performance Liquid Chromatography-diode array detector was the technique most applied, with which the same structures were identified all through the studies, although other unknown structures were detected, but not elucidated. The use of Nuclear Magnetic Resonance and Mass Spectrometry, which are more sensitive techniques, needs to be intensified, to identify other unconventional compounds detected in Passiflora, to enhance the comprehension of the bioactive compounds in these plants.
Local Directional Ternary Pattern for Facial Expression Recognition

This paper presents a new face descriptor, local directional ternary pattern (LDTP), for facial expression recognition. LDTP efficiently encodes information of emotion-related features (ı.e., eyes, eyebrows, upper nose, and mouth) by using the directional information and ternary pattern in order to take advantage of the robustness of edge patterns in the edge region while overcoming weaknesses of edge-based methods in smooth regions. Our proposal, unlike existing histogram-based face description methods that divide the face into several regions and sample the codes uniformly, uses a two-level grid to construct the face descriptor while sampling expression-related information at different scales. We use a coarse grid for stable codes (highly related to non-expression), and a finer one for active codes (highly related to expression). This multi-level approach enables us to do a finer grain description of facial motions while still characterizing the coarse features of the expression. Moreover, we learn the active LDTP codes from the emotion-related facial regions. We tested our method by using person-dependent and independent cross-validation schemes to evaluate the performance. We show that our approaches improve the overall accuracy of facial expression recognition on six data sets.
Comprehensive Molecular Screening in Chinese Usher Syndrome Patients.

Purpose Usher syndrome (USH) refers to a group of autosomal recessive disorders causing deafness and blindness. The objectives of this study were to determine the mutation spectrum in a cohort of Chinese patients with USH and to describe the clinical features of the patients with mutations. Methods A total of 119 probands who were clinically diagnosed with USH were recruited for genetic analysis. All probands underwent ophthalmic examinations. A combination of molecular screening methods, including targeted next-generation sequencing, Sanger-DNA sequencing, and multiplex ligation probe amplification assay, was used to detect mutations. Results We found biallelic mutations in 92 probands (77.3%), monoallelic mutations in 5 patients (4.2%), and 1 hemizygous mutation in 1 patient (0.8%), resulting in an overall mutation detection rate of 78.2%. Overall, 132 distinct disease-causing mutations involving seven USH (ABHD12, CDH23, GPR98, MYO7A, PCDH15, USH1C, and USH2A) genes; 5 other retinal degeneration genes (CHM, CNGA1, EYS, PDE6B, and TULP1); and 1 nonsyndromic hearing loss gene (MYO15A) were identified, and 78 were novel. Mutations of MYOA7 were responsible for 60% of USH1 families, followed by PCDH15 (20%) and USH1C (10%). Mutations of USH2A accounted for 67.7% of USH2 families, and mutation c.8559-2A>G was the most frequent one, accounting for 19.1% of the identified USH2A alleles. Conclusions Our results confirm that the mutation spectrum for each USH gene in Chinese patients differs from those of other populations. The formation of the mutation profile for the Chinese population will enable a precise genetic diagnosis for USH patients in the future.
Physiotherapy for Patients with Sciatica Awaiting Lumbar Micro‐discectomy Surgery: A Nested, Qualitative Study of Patients' Views and Experiences

Abstract Background and Purpose Sciatica is a common clinical condition that can be extremely painful, disabling and life‐changing. Whether conservative or surgical treatment for sciatica secondary to an intervertebral disc prolapse is most effective is still much debated. An important component of conservative treatment is physiotherapy, which aims to promote physical and psychological health for the patient, whilst resorption of the disc takes place. This paper reports a qualitative study of patients' views and experiences of a bespoke physiotherapy intervention for the treatment of sciatica. Methods A qualitative study nested within a pilot randomized controlled trial of bespoke physiotherapy for the treatment of patients with sciatica awaiting lumbar microdiscectomy surgery. Patients randomized to receive bespoke physiotherapy in the intervention arm of the trial were invited to take part in semi‐structured interviews. Twenty‐one in‐depth, semi‐structured interviews took place. All interviews were recorded, fully transcribed and thematically analysed. Results Most patients in the sample found the physiotherapy valuable, appreciating the individual nature of the approach, the exercises to reduce pain and discomfort, techniques for improving functional spinal movement, walking and dynamic posture, and manual therapy and cardiovascular exercise. A small number did not find the physiotherapy of benefit. Sixteen patients in the sample went on to proceed with surgery, but most of these found value in having had the physiotherapy first. Discussion Many patients with sciatica appreciate the value of physiotherapy prior to surgery. Future research should examine patients' experiences of bespoke physiotherapy delivered within primary care. Copyright © 2016 The Authors Physiotherapy Research International published by John Wiley & Sons Ltd.
Trends in Severity of Illness on ICU Admission and Mortality among the Elderly

Background There is an increase in admission rate for elderly patients to the ICU. Mortality rates are lower when more liberal ICU admission threshold are compared to more restrictive threshold. We sought to describe the temporal trends in elderly admissions and outcomes in a tertiary hospital before and after the addition of an 8-bed medical ICU. Methods We conducted a retrospective analysis of a comprehensive longitudinal ICU database, from a large tertiary medical center, examining trends in patients’ characteristics, severity of illness, intensity of care and mortality rates over the years 2001–2008. The study population consisted of elderly patients and the primary endpoints were 28 day and one year mortality from ICU admission. Results Between the years 2001 and 2008, 7,265 elderly patients had 8,916 admissions to ICU. The rate of admission to the ICU increased by 5.6% per year. After an eight bed MICU was added, the severity of disease on ICU admission dropped significantly and crude mortality rates decreased thereafter. Adjusting for severity of disease on presentation, there was a decreased mortality at 28- days but no improvement in one- year survival rates for elderly patient admitted to the ICU over the years of observation. Hospital mortality rates have been unchanged from 2001 through 2008. Conclusion In a high capacity ICU bed hospital, there was a temporal decrease in severity of disease on ICU admission, more so after the addition of additional medical ICU beds. While crude mortality rates decreased over the study period, adjusted one-year survival in ICU survivors did not change with the addition of ICU beds. These findings suggest that outcome in critically ill elderly patients may not be influenced by ICU admission. Adding additional ICU beds to deal with the increasing age of the population may therefore not be effective.
Versatile Locomotion Control of a Hexapod Robot Using a Hierarchical Network of Nonlinear Oscillator Circuits

A novel hierarchical network based on coupled nonlinear oscillators is proposed for motor pattern generation in hexapod robots. Its architecture consists of a central pattern generator (CPG), producing the global leg coordination pattern, coupled with six local pattern generators, each devoted to generating the trajectory of one leg. Every node comprises a simple nonlinear oscillator and is well-suited for implementation in a standard field-programmable analog array device. The network enables versatile locomotion control based on five high-level parameters which determine the inter-oscillator coupling pattern via simple rules. The controller was realized on dedicated hardware, deployed to control an ant-like hexapod robot, and multi-sensory telemetry was performed. As a function of a single parameter, it was able to stably reproduce the canonical gaits observed in six-legged insects, namely the wave, tetrapod, and tripod gaits. A second parameter enabled driving the robot in ant-like and cockroach-like postures. Three further parameters enabled inhibiting and resuming walking, steering, and producing uncoordinated movement. Emergent phenomena were observed in the form of a multitude of intermediate gaits and of hysteresis and metastability close to a point of gait transition. The primary contributions of this paper reside in the hierarchical controller architecture and associated approach for collapsing a large set of low-level parameters, stemming from the complex hexapod kinematics, into only five high-level parameters. Such parameters can be changed dynamically, an aspect of broad practical relevance opening new avenues for driving hexapod robots via afferent signals from other circuits representing higher brain areas, or by means of suitable brain-computer interfaces. An additional contribution is the detailed characterization via telemetry of the physical robot, involving the definition of parameters which may aid future comparison with other controllers. The present results renew interest into analog CPG architectures and reinforce the generality of the connectionist approach.
Stem cell therapy for ischemic heart diseases.

Introduction Ischemic heart diseases, especially the myocardial infarction, is a major hazard problem to human health. Despite substantial advances in control of risk factors and therapies with drugs and interventions including bypass surgery and stent placement, the ischemic heart diseases usually result in heart failure (HF), which could aggravate social burden and increase the mortality rate. The current therapeutic methods to treat HF stay at delaying the disease progression without repair and regeneration of the damaged myocardium. While heart transplantation is the only effective therapy for end-stage patients, limited supply of donor heart makes it impossible to meet the substantial demand from patients with HF. Stem cell-based transplantation is one of the most promising treatment for the damaged myocardial tissue. Sources of data Key recent published literatures and ClinicalTrials.gov. Areas of agreement Stem cell-based therapy is a promising strategy for the damaged myocardial tissue. Different kinds of stem cells have their advantages for treatment of Ischemic heart diseases. Areas of controversy The efficacy and potency of cell therapies vary significantly from trial to trial; some clinical trials did not show benefit. Diverged effects of cell therapy could be affected by cell types, sources, delivery methods, dose and their mechanisms by which delivered cells exert their effects. Growing points Understanding the origin of the regenerated cardiomyocytes, exploring the therapeutic effects of stem cell-derived exosomes and using the cell reprogram technology to improve the efficacy of cell therapy for cardiovascular diseases. Areas timely for developing research Recently, stem cell-derived exosomes emerge as a critical player in paracrine mechanism of stem cell-based therapy. It is promising to exploit exosomes-based cell-free therapy for ischemic heart diseases in the future.
Position-aware Attention and Supervised Data Improve Slot Filling

Organized relational knowledge in the form of “knowledge graphs” is important for many applications. However, the ability to populate knowledge bases with facts automatically extracted from documents has improved frustratingly slowly. This paper simultaneously addresses two issues that have held back prior work. We first propose an effective new model, which combines an LSTM sequence model with a form of entity position-aware attention that is better suited to relation extraction. Then we build TACRED, a large (119,474 examples) supervised relation extraction dataset obtained via crowdsourcing and targeted towards TAC KBP relations. The combination of better supervised data and a more appropriate high-capacity model enables much better relation extraction performance. When the model trained on this new dataset replaces the previous relation extraction component of the best TAC KBP 2015 slot filling system, its F1 score increases markedly from 22.2% to 26.7%.
Composition and phase analysis of nanocrystalline BaxSr1-xFe12O19 (x = 1.0; 0.6; and 0.4) by using general structure analysis system

Single phase of nanocrystalline BaxSr1-xFe12O19 (x = 1.0; 0.6; and 0.4) was successfully synthesized by mechanical milling method and thermal process. Stoichiometric quantities of analytical-grade SrCO3, BaCO3, and Fe2O3, were mixed and milled using a high-energy milling. The mixture of all precursors was sintered at a temperature of 1000 °C for 10 hours. The refinement of x-ray diffraction trace for all samples confirmed a single phase material with a hexagonal structure. The increase of the amount of strontium content in the barium atoms in the BaxSr1-xFe12O19 system can decrease the lattice parameter which have been successfully substituted into the barium atoms. The calculation result of cationic distribution showed that the BaxSr1-xFe12O19 (x = 0.6) and (x = 0.4) samples have nominal composition of Ba0,61Sr0,39Fe12O19 and Ba0,37Sr0,63Fe12O19, respectively. Results of the mean of crystallite size evaluation for respective powder materials showed that the BaxSr1-xFe12O19 (x = 1.0; 0.6; and 0.4) samples.
Access delay of efficient media access schemes for wireless LAN with smart antenna

An exact approach to analyze the access delay of the media access schemes that employ beamforming to locate users out of the broadcast range of the access point (AP) in a WLAN is put forward. Results show that the scheme which distinguishes the users residing in or out of broadcast range of the AP can provide rapider media access. And then the simulation verifies the proposed approach.
Magnetic resonance imaging of ultrasmall superparamagnetic iron oxide-labeled exosomes from stem cells: a new method to obtain labeled exosomes

Purpose Recent findings indicate that the beneficial effects of adipose stem cells (ASCs), reported in several neurodegenerative experimental models, could be due to their paracrine activity mediated by the release of exosomes. The aim of this study was the development and validation of an innovative exosome-labeling protocol that allows to visualize them with magnetic resonance imaging (MRI). Materials and methods At first, ASCs were labeled using ultrasmall superparamagnetic iron oxide nanoparticles (USPIO, 4–6 nm), and optimal parameters to label ASCs in terms of cell viability, labeling efficiency, iron content, and magnetic resonance (MR) image contrast were investigated. Exosomes were then isolated from labeled ASCs using a standard isolation protocol. The efficiency of exosome labeling was assessed by acquiring MR images in vitro and in vivo as well as by determining their iron content. Transmission electron microscopy images and histological analysis were performed to validate the results obtained. Results By using optimized experimental parameters for ASC labeling (200 µg Fe/mL of USPIO and 72 hours of incubation), it was possible to label 100% of the cells, while their viability remained comparable to unlabeled cells; the detection limit of MR images was of 102 and 2.5×103 ASCs in vitro and in vivo, respectively. Exosomes isolated from previously labeled ASCs retain nanoparticles, as demonstrated by transmission electron microscopy images. The detection limit by MRI was 3 µg and 5 µg of exosomes in vitro and in vivo, respectively. Conclusion We report a new approach for labeling of exosomes by USPIO that allows detection by MRI while preserving their morphology and physiological characteristics.