Miracle-dz/UniFAR-FTUs huggingface dataset:
Force-constant model for the vibrational modes in C60.

A force-constant model previously developed for C 60 is extended to C 70 . Using the force constants determined for the C 60 molecule, the vibrational frequencies for the C 70 molecule are calculated and are identified with the irreducible representations of the D 5h symmetry group, according to which the vibrational modes transform. A comparison of the predictions of this model with the experimentally reported values for the Raman- and infrared-active modes shows good agreement overall. The effect of doping by alkali-metal atoms is taken into account by modifying the force constants in order to produce a good fit to the available data for doped C 60
A Carcinoembryonic Antigen-Secreting Adenocarcinoma Arising in Tailgut Cyst : Clinical Implications of Carcinoembryonic Antigen

Tailgut cysts (TGCs) are rare congenital cysts that occur in the retrorectal or presacral spaces. Although most tailgut cysts have been reported as benign, there have been at least 9 cases associated with malignant change. We report herein on an unusual case of a 40-year-old woman with a carcinoembryonic antigen (CEA)-producing adenocarcinoma arising within a TGC who underwent surgical resection and local radiation therapy. Despite the complete resection, metastatic adenocarcinoma developed five months after surgery. CEA-producing adenocarcinoma from a TGC is extremely rare and only two cases, including this case, have been reported in the English medical literature. Besides CEA, the serum levels of CA 19-9 became markedly elevated in this patient. Given that the serum CEA level decreased to the normal range after complete resection of tumor and that the tumor recurrence was associated with a rebound of the CEA serum level, our case shows that serial measurements of serum CEA can be used for treatment planning and for assessing the patient's treatment response for this rare disease.
Identification of a Novel Coronavirus from a Beluga Whale by Using a Panviral Microarray

ABSTRACT The emergence of viruses such as severe acute respiratory syndrome coronavirus and Nipah virus has underscored the role of animal reservoirs in human disease and the need for reservoir surveillance. Here, we used a panviral DNA microarray to investigate the death of a captive beluga whale in an aquatic park. A highly divergent coronavirus, tentatively named coronavirus SW1, was identified in liver tissue from the deceased whale. Subsequently, the entire genome of SW1 was sequenced, yielding a genome of 31,686 nucleotides. Phylogenetic analysis revealed SW1 to be a novel virus distantly related to but most similar to group III coronaviruses.
Minimum curvilinearity to enhance topological prediction of protein interactions by network embedding

Motivation: Most functions within the cell emerge thanks to protein–protein interactions (PPIs), yet experimental determination of PPIs is both expensive and time-consuming. PPI networks present significant levels of noise and incompleteness. Predicting interactions using only PPI-network topology (topological prediction) is difficult but essential when prior biological knowledge is absent or unreliable. Methods: Network embedding emphasizes the relations between network proteins embedded in a low-dimensional space, in which protein pairs that are closer to each other represent good candidate interactions. To achieve network denoising, which boosts prediction performance, we first applied minimum curvilinear embedding (MCE), and then adopted shortest path (SP) in the reduced space to assign likelihood scores to candidate interactions. Furthermore, we introduce (i) a new valid variation of MCE, named non-centred MCE (ncMCE); (ii) two automatic strategies for selecting the appropriate embedding dimension; and (iii) two new randomized procedures for evaluating predictions. Results: We compared our method against several unsupervised and supervisedly tuned embedding approaches and node neighbourhood techniques. Despite its computational simplicity, ncMCE-SP was the overall leader, outperforming the current methods in topological link prediction. Conclusion: Minimum curvilinearity is a valuable non-linear framework that we successfully applied to the embedding of protein networks for the unsupervised prediction of novel PPIs. The rationale for our approach is that biological and evolutionary information is imprinted in the non-linear patterns hidden behind the protein network topology, and can be exploited for predicting new protein links. The predicted PPIs represent good candidates for testing in high-throughput experiments or for exploitation in systems biology tools such as those used for network-based inference and prediction of disease-related functional modules. Availability: https://sites.google. com/site/carlovittoriocannistraci/home Contact: kalokagathos.agon@gmail.com or timothy.ravasi@kaust.edu. sa Supplementary information: Supplementary data are available at Bioinformatics online.
Experience-Oriented and Product-Oriented Evaluation: Psychological Need Fulfillment, Positive Affect, and Product Perception

We collected over a thousand technology-mediated positive experiences with media and obtained measures describing aspects of the experience itself (affect, psychological need fulfillment) and of the product (i.e., content and technology) integral to the experience (pragmatic quality, hedonic quality). We found a strong relation between intensity of need fulfillment and positive affect. Furthermore, different activities had different need profiles. Watching was foremost a relatedness experience, listening a stimulation and meaning experience, and playing a competence experience. Need fulfillment and positive affect was related to perceptions of hedonic quality, however moderated through attribution, that is, the belief that the product played a role in creating the experience. Pragmatic quality was not linked to experiential measures. The present study (a) demonstrates the merits of distinguishing between an experience-oriented and a product-oriented evaluation, (b) suggests a set of possible measurement instruments for experience-oriented and a product-oriented evaluation, and (c) details the process of how positive experience is transformed into positive product perceptions and judgments of appeal.
A Sponge-like Structure Involved in the Association and Transport of Maternal Products during Drosophila Oogenesis

Localization of maternally provided RNAs during oogenesis is required for formation of the antero–posterior axis of the Drosophila embryo. Here we describe a subcellular structure in nurse cells and oocytes which may function as an intracellular compartment for assembly and transport of maternal products involved in RNA localization. This structure, which we have termed “sponge body,” consists of ER-like cisternae, embedded in an amorphous electron-dense mass. It lacks a surrounding membrane and is frequently associated with mitochondria. The sponge bodies are not identical to the Golgi complexes. We suggest that the sponge bodies are homologous to the mitochondrial cloud in Xenopus oocytes, a granulo-fibrillar structure that contains RNAs involved in patterning of the embryo. Exuperantia protein, the earliest factor known to be required for the localization of bicoid mRNA to the anterior pole of the Drosophila oocyte, is highly enriched in the sponge bodies but not an essential structural component of these. RNA staining indicates that sponge bodies contain RNA. However, neither the intensity of this staining nor the accumulation of Exuperantia in the sponge bodies is dependent on the amount of bicoid mRNA present in the ovaries. Sponge bodies surround nuage, a possible polar granule precursor. Microtubules and microfilaments are not present in sponge bodies, although transport of the sponge bodies through the cells is implied by their presence in cytoplasmic bridges. We propose that the sponge bodies are structures that, by assembly and transport of included molecules or associated structures, are involved in localization of mRNAs in Drosophila oocytes.
A framework for interpreting functional networks in schizophrenia

Some promising genetic correlates of schizophrenia have emerged in recent years but none explain more than a small fraction of cases. The challenge of our time is to characterize the neuronal networks underlying schizophrenia and other neuropsychiatric illnesses. Early models of schizophrenia have been limited by the ability to readily evaluate large-scale networks in living patients. With the development of resting state and advanced structural magnetic resonance imaging, it has become possible to do this. While we are at an early stage, a number of models of intrinsic brain networks have been developed to account for schizophrenia and other neuropsychiatric disorders. This paper reviews the recent voxel-based morphometry (VBM), diffusion tensor imaging (DTI), and resting functional magnetic resonance imaging literature in light of the proposed networks underlying these disorders. It is suggested that there is support for recently proposed models that suggest a pivotal role for the salience network. However, the interactions of this network with the default mode network and executive control networks are not sufficient to explain schizophrenic symptoms or distinguish them from other neuropsychiatric disorders. Alternatively, it is proposed that schizophrenia arises from a uniquely human brain network associated with directed effort including the dorsal anterior and posterior cingulate cortex (PCC), auditory cortex, and hippocampus while mood disorders arise from a different brain network associated with emotional encoding including the ventral anterior cingulate cortex (ACC), orbital frontal cortex, and amygdala. Both interact with the dorsolateral prefrontal cortex and a representation network including the frontal and temporal poles and the fronto-insular cortex, allowing the representation of the thoughts, feelings, and actions of self and others across time.
Expressive suppression and enhancement during music-elicited emotions in younger and older adults

When presented with emotional visual scenes, older adults have been found to be equally capable to regulate emotion expression as younger adults, corroborating the view that emotion regulation skills are maintained or even improved in later adulthood. However, the possibility that gaze direction might help achieve an emotion control goal has not been taken into account, raising the question whether the effortful processing of expressive regulation is really spared from the general age-related decline. Since it does not allow perceptual attention to be redirected away from the emotional source, music provides a useful way to address this question. In the present study, affective, behavioral, and physiological consequences of free expression of emotion, expressive suppression and expressive enhancement were measured in 31 younger and 30 older adults while they listened to positive and negative musical excerpts. The main results indicated that compared to younger adults, older adults reported experiencing less emotional intensity in response to negative music during the free expression of emotion condition. No age difference was found in the ability to amplify or reduce emotional expressions. However, an age-related decline in the ability to reduce the intensity of emotional state and an age-related increase in physiological reactivity were found when participants were instructed to suppress negative expression. Taken together, the current data support previous findings suggesting an age-related change in response to music. They also corroborate the observation that older adults are as efficient as younger adults at controlling behavioral expression. But most importantly, they suggest that when faced with auditory sources of negative emotion, older age does not always confer a better ability to regulate emotions.
Joint power control and user association for traffic offloading in heterogeneous networks

A heterogeneous network (HetNet), which consists of macro cells and small cells, is an effective tool to improve the system spectral efficiency by exploiting the benefit of spatial reuse. However, the benefit of HetNet is limited by the asymmetry of transmit power between macro base stations (BSs) and pico BSs. Traditional solutions lead to a tradeoff between received signal strength (RSS) and load balancing. To tackle this problem, we propose a novel mechanism with joint macro BS transmit power control and load-aware user association. As such, we can realize traffic offloading from the macro cell to pico cells in a two-tier HetNet and mitigate inter-cell interference (ICI) in the network. We formulate this problem as a nonlinear integer programming problem, and prove that it is NP-hard. We then propose a polynomial-time heuristic. The simulation results show that our algorithm is indeed an efficient mechanism with better network performance in terms of average throughput and fairness.
Plasma Concentrations of Vitamin D Metabolites in Premature Infants

Summary: The plasma concentrations of 25-hydroxyvitamin D (OHD), 1,25-(OH)2D and 24,25-(OH)2D were determined in 28 healthy premature infants(median gestational age 33, range 28-36 wk; and median birth weight 1880, range 900-2350 g) during the first 5-10 wk of life,and in a reference group of 17 young adults. The infants received a vitamin D supplement of 500 IU/d and a diet low in calcium (Ca)and phophorus (P) compared with that of corresponding intrauterine accretion rates.The median 25-OHD concentration increased from 11 (range 6-30) ng/ml at 1 d to 27 (range, 15-41) ng/ml by 5-10 wk of age (P < 0.01). 1,25-(OH)2D concentrations at age 1 d were similar to the adult levels (median 37, range 8-64 versus 35, range 18-58 pg/ml), but increased significantly within 1 wk to 48 (26-156) pg/ml (P=0.01), and between 1 and 3-4wk of age to 104 (58-203) pg/ml (P < 0.01). The levels at 5-10 wk were similar to the 3-4 wk value. 24,25-(OH)2D concentrations were persistently low compared with the adult levels (medians 0.4-0.5, range < 0.3-2.1 versus 1.7, range 0.4-2.0 ng/ml, P < 0.01). The relative concentrations, expressed as the ratio of 24,25-(OH)2D to 25-OHD, were comparable to those of the adults at birth, but decreased significantly within 2 wk. The data demonstrate that healthypremature infants can produce high plasma levels of 1,25-(OH)2D.
Gender, teaching and academic promotions in higher education

ABSTRACT Teaching is increasingly being considered for inclusion in academic promotions in a number of universities. This raises questions about how teaching is appraised in relation to research; and which teaching criteria contribute to promotions outcomes. This article investigates these questions from a gender perspective by statistically analysing the actual promotions outcomes by rank levels at a South African university where teaching and research have been equally evaluated in academic promotions. The findings show that, overall, there was no statistically significant difference in promotions success rates between males and females and that more females achieved excellence in teaching with higher scores than males. Two of the 10 teaching criteria analysed – ‘ongoing study of tertiary education’ and ‘special recognition of teaching’ showed statistically significantly higher scores for females with high effect sizes, pointing to the importance of the Scholarship of Teaching and Learning in academic promotions for women. This study has implications for closing the gender gap in the senior ranks of universities.
Comparative study of transient disturbances impact on 2G and 4G telecommunication systems in a railway context

For reliability and safety purposes, the signaling systems in the railway domain are continuously evolving. Today, in Europe, the GSM-R is used as a part of the European Railway Traffic Management System (ERTMS) and the transmission of signaling information is increasingly ensured by the GSM-R. With the evolution of the telecommunication systems, new technologies using OFDM techniques, such as LTE could be exploited for railway applications. However, knowing that the railway electromagnetic environment is very hostile and rich in terms of electromagnetic interferences, studies need to be carried out to anticipate the EMC issues that could impact LTE performances. In this paper, we propose a comparative study between GSM-R and LTE communications in the presence of transient electromagnetic interferences, generally present on board trains.
The Use of Multiple Correspondence Analysis to Explore Associations between Categories of Qualitative Variables in Healthy Ageing

The main focus of this study was to illustrate the applicability of multiple correspondence analysis (MCA) in detecting and representing underlying structures in large datasets used to investigate cognitive ageing. Principal component analysis (PCA) was used to obtain main cognitive dimensions, and MCA was used to detect and explore relationships between cognitive, clinical, physical, and lifestyle variables. Two PCA dimensions were identified (general cognition/executive function and memory), and two MCA dimensions were retained. Poorer cognitive performance was associated with older age, less school years, unhealthier lifestyle indicators, and presence of pathology. The first MCA dimension indicated the clustering of general/executive function and lifestyle indicators and education, while the second association was between memory and clinical parameters and age. The clustering analysis with object scores method was used to identify groups sharing similar characteristics. The weaker cognitive clusters in terms of memory and executive function comprised individuals with characteristics contributing to a higher MCA dimensional mean score (age, less education, and presence of indicators of unhealthier lifestyle habits and/or clinical pathologies). MCA provided a powerful tool to explore complex ageing data, covering multiple and diverse variables, showing if a relationship exists and how variables are related, and offering statistical results that can be seen both analytically and visually.
Religion and the media in GCSE and A-level syllabuses: a regrettable gap and proposals to fill it

Abstract Existing GCSE and A-level syllabuses include modules on religion and the media, but these have not been widely or well studied for a variety of reasons. The modules may be considered difficult to teach well, and teachers have few good resources to use in comparison with more popular topics such as medical or environmental ethics. The newly launched specifications for RS GCSE and A-level examinations have eliminated, almost entirely, any study of religion and the media. The absence of this theme is troubling. There is a strong case to be made that critical appreciation of the ways media depicts religion is especially important for forming responsible, educated citizens in modern Britain, many of whom will not participate directly in religious communities but will see much depiction of such communities and their ideologies in the media. We propose key principles and questions that might help equip teachers to tackle critically and intelligently issues about religion in the media as they arise. We illustrate this approach by considering media responses to the Charlie Hebdo attacks in Paris.
Discriminatively trained dependency language modeling for conversational speech recognition

We present a discriminatively trained dependency parser-based language model. The model operates on utterances, rather than words, and so can utilize long-distance structural features of each sentence. We train the model discriminatively on n -best lists, using the perceptron algorithm to tune the model weights. Our features include standard n -gram style features, long-distance co-occurrence features, and syntactic structural features. We evaluate this model by re-ranking n - best lists of recognized speech from the Fisher dataset of informal telephone conversations. We compare various combinations of feature types, and methods of training the model.
History of Miscarriage and Increased Incidence of Fetal Aneuploidy in Subsequent Pregnancy

OBJECTIVE: The purpose of this study was to examine the association between history of spontaneous abortion and aneuploidy in a subsequent pregnancy. METHODS: This was a retrospective cohort study of women who underwent fetal karyotype analysis with amniocentesis or chorionic villus sampling at a single prenatal diagnosis center. Information on spontaneous abortions, parity, maternal age, ethnicity, type of prenatal diagnosis, and karyotype was assessed. Univariable and multivariable analyses were conducted. RESULTS: A total of 46,939 women were included in our analysis. Women with no prior spontaneous abortions had a 1.39% risk for any aneuploidy. In women with one prior spontaneous abortion, this risk increased to 1.67%; for women with 2 previous spontaneous abortions, the risk increased to 1.84%; and for those women who had had 3 or more prior spontaneous abortions, the risk increased further to 2.18% (P < .007). When controlling for maternal age, parity, ethnicity, and mode of prenatal diagnosis and compared with women with no prior spontaneous abortions, women with one prior spontaneous abortion (adjusted odds ratio [AOR] 1.21, 95% confidence interval [CI] 1.01–1.47) or 3 or more prior spontaneous abortions (AOR 1.51, 95% CI 1.02–2.25) had a statistically significant increase in aneuploidy in a subsequent pregnancy. Women with 2 prior spontaneous abortions had an AOR of 1.26 for aneuploidy, but the 95% CI contained unity. CONCLUSION: An increased risk of karyotypic abnormality identified at the time of prenatal diagnosis is demonstrated in patients with an increasing number of spontaneous abortions. This study provides information regarding this risk among women presenting for prenatal diagnosis. According to our data, for a woman with an a priori risk of 1 in 300 for Down syndrome, 3 prior spontaneous abortions would increase that risk by 47% to 1 in 204. These results should be confirmed in low-risk populations. LEVEL OF EVIDENCE: II-2
Stimulus novelty and significance as determinants of electrodermal responsivity: the serial position effect.

Three experiments examined the effects of stimulus novelty and significance on the skin conductance component of the orienting response. The test stimuli used in the different experiments involved either a neutral change in stimulation (i.e., adding or deleting components to the standard stimuli), or an introduction of a significant element to the standard stimulus. The serial position of the test stimulus was manipulated in all three experiments. In Experiment 1, nonsignificant test stimuli were introduced at the second, fourth, sixth, or eighth trial of the complex sequence of eight stimuli (i.e., a sequence comprised of varying standard stimuli). None of the test stimuli produced enhanced skin conductance responses under these conditions. Experiment 2 utilized the same design with only one difference: the test stimuli were presented following a simple stimulus sequence (i.e., repetition of a fixed standard stimulus). In this design enhanced skin conductance responses to the test stimuli were observed in almost all experimental conditions, with an advantage of a late over an early presentation of the test stimulus. Experiment 3 was designed to compare serial position effects of significant and neutral test stimuli. A serial position effect was obtained only for the neutral test stimuli, showing once again an advantage for late presentations. It was suggested that different mechanisms might underlie skin conductance responses to significant stimuli and to novel neutral stimuli.