Miracle-dz/UniFAR-FTUs huggingface dataset:
The impact of augmentative and alternative communication intervention on the speech production of individuals with developmental disabilities: a research review.

PURPOSE This article presents the results of a meta-analysis to determine the effect of augmentative and alternative communication (AAC) on the speech production of individuals with developmental disabilities. METHOD A comprehensive search of the literature published between 1975 and 2003, which included data on speech production before, during, and after AAC intervention, was conducted using a combination of electronic and hand searches. RESULTS The review identified 23 studies, involving 67 individuals. Seventeen of these studies did not establish experimental control, thereby limiting the certainty of evidence about speech outcomes. The remaining 6 studies, involving 27 cases, had sufficient methodological rigor for the "best evidence analysis" (cf. >R. E. Slavin, 1986). Most of the participants (aged 2-60 years) had mental retardation or autism; the AAC interventions involved instruction in manual signs or nonelectronic aided systems. None of the 27 cases demonstrated decreases in speech production as a result of AAC intervention, 11% showed no change, and the majority (89%) demonstrated gains in speech. For the most part, the gains observed were modest, but these data may underestimate the effect of AAC intervention on speech production because there were ceiling effects. CONCLUSIONS Future research is needed to better delineate the relationship between AAC intervention and speech production across a wider range of participants and AAC interventions.
Dark Repair of Ultraviolet-Irradiated Deoxyribonucleic Acid by Bacteriophage T4: Purification and Characterization of a Dimer-Specific Phage-Induced Endonuclease

The purification and properties of an ultraviolet (UV) repair endonuclease are described. The enzyme is induced by infection of cells of Escherichia coli with phage T4 and is missing from extracts of cells infected with the UV-sensitive and excision-defective mutant T4V1. The enzyme attacks UV-irradiated deoxyribonucleic acid (DNA) containing either hydroxymethylcytosine or cytosine, but does not affect native DNA. The specific substrate in UV-irradiated DNA appears to be pyrimidine dimer sites. The purified enzyme alone does not excise pyrimidine dimers from UV-irradiated DNA. However, dimer excision does occur in the presence of the purified endonuclease plus crude extract of cells infected with the mutant T4V1.
Accounting Choice, Home Bias, and Us Investment in Non-Us Firms

This paper examines the relation between accounting method choice and investment by US institutional investors in non-US firms. Such a relation could be driven by two factors. First, home bias in US investment could result in preferences for accounting practices familiar to US investors. The use of accounting methods consistent with US GAAP reduces information processing costs for US investors, allowing for more thorough analyses and increasing the credibility of the financial information. Second, many sources consider US GAAP to be one of the highest quality sets of financial reporting standards in the world. Thus, US investors likely perceive firms that use accounting methods allowed under US GAAP as having higher accounting quality. We find that firms with higher degrees of conformity with US GAAP have greater levels of US institutional ownership. These associations are exhibited in levels and changes, and are robust to the inclusion of a number of control variables for other determinants of institutional investment. Lead/lag regressions suggest that increases in US GAAP conformity attract a higher level of US institutional investment in future periods, but changes in US institutional holdings do not lead to changes in accounting methods. In partition analyses, we find that the positive relation between US GAAP conformity and US institutional investment holds regardless of a firm's ADR status or other proxies for visibility (e.g., stock index listing, analyst following, and firm size). However, the relation is significantly stronger in the subsamples of ADR firms and more visible firms, suggesting that US GAAP conformity has greater impact among firms already somewhat visible to US investors.
Necrostatin-1 inhibits the degeneration of neural cells induced by aluminum exposure.

PURPOSE There are many in vivo and in vitro studies suggested the involvement of apoptosis in neurodegenerative processes. There is considerable evidence that various complex events may contribute to neural cell death. The present study focuses on the underlined neurodegenerative mechanism and the preventive effect of necrostatin-1 (Nec-1) on neural cell death induced by aluminum (Al). METHODS Al-exposed primary cultures of newborn mice cortical cells were separately treated with 3-methylamphetamine (3-MA), benzyloxycarbonylvalyl-alanyl-aspartic acid (O-methyl)-fluoro-methylketone (zVAD-fmk), and Nec-1, the cell viability analysis was used to evaluate cell damage from apoptosis, necroptosis and autophagy. Morphology of neural cells treated with 2 mM Al, and 2 mM Al plus 60 μM Nec-1 were examined by fluorescent microscope, and the cell death rates were quantified by cytometry. For the in vivo experiments, male ICR mice were microinjected with normal saline, 2 mM Al, and 2 mM Al plus Nec-1 at the concentrations of 2 mM, 4 mM and 8 mM into the lateral cerebral ventricles. The Morris water maze task was performed in 20 days after intracerebroventricular injection, Nissl staining was used to demonstrate the loss of Nissl substance and the number of neural cells, and western blot was used to analyze the expressing of cell death and Alzheimer's disease related proteins. RESULTS The cell viabilities inhibited by Al could be enhanced by 3-MA, zVAD-fmk and Nec-1, of which Nec-1 improved the cell viability most significantly. Furthermore, the cell viability of neural cells treated with Nec-1 increased concentration-dependently, and the expressions of cell death-related proteins were decreased also in a concentration-dependent manner. The in vivo experiments indicated that administration of Nec-1 on Al-treated mice significantly improved learning and memory retention in the Morris water maze task, decreased the neural cells death and inhibited the expression of Alzheimer's disease related proteins in the mice brain. CONCLUSIONS The present study provides the first direct evidence of a connection between necroptosis and neurodegeneration, which indicates that necroptosis is involved in neurodegenerative cell death. Furthermore, Nec-1 may be useful for the prevention and treatment of neurodegenerative disorders.
Novel LQT-3 Mutation Affects Na+ Channel Activity Through Interactions Between α- and β1-Subunits

Abstract —The congenital long-QT syndrome (LQT), an inherited cardiac arrhythmia characterized in part by prolonged ventricular repolarization, has been linked to 5 loci, 4 of which have been shown to harbor genes that encode ion channels. Previously studied LQT-3 mutations of SCN5A (or hH1), the gene that encodes the human Na+ channel α-subunit, have been shown to encode voltage-gated Na+ channels that reopen during prolonged depolarization and hence directly contribute to the disease phenotype: delayed repolarization. Here, we report the functional consequences of a novel SCN5A mutation discovered in an extended LQT family. The mutation, a single A→G base substitution at nucleotide 5519 of the SCN5A cDNA, is expected to cause a nonconservative change from an aspartate to a glycine at position 1790 (D1790G) of the SCN5A gene product. We investigated ion channel activity in human embryonic kidney (HEK 293) cells transiently transfected with wild-type (hH1) or mutant (D1790G) cDNA alone or in combination with cDNA encoding the human Na+ channel β1-subunit (hβ1) using whole-cell patch-clamp procedures. Heteromeric channels formed by coexpression of α- and β1-subunits are affected: steady-state inactivation is shifted by –16 mV, but there is no D1790G-induced sustained inward current. This effect is independent of the β1-subunit isoform. We find no significant effect of D1790G on the biophysical properties of monomeric α- (hH1) channels. We conclude that the effects of the novel LQT-3 mutation on inactivation of heteromeric channels are due to D1790G-induced changes in α- and β1-interactions.
Role of Alginate O Acetylation in Resistance of Mucoid Pseudomonas aeruginosa to Opsonic Phagocytosis

ABSTRACT Establishment and maintenance of chronic lung infections with mucoid Pseudomonas aeruginosa in patients with cystic fibrosis (CF) require that the bacteria avoid host defenses. Elaboration of the extracellular, O-acetylated mucoid exopolysaccharide, or alginate, is a major microbial factor in resistance to immune effectors. Here we show that O acetylation of alginate maximizes the resistance of mucoid P. aeruginosa to antibody-independent opsonic killing and is the molecular basis for the resistance of mucoid P. aeruginosa to normally nonopsonic but alginate-specific antibodies found in normal human sera and sera of infected CF patients. O acetylation of alginate appears to be critical for P. aeruginosa resistance to host immune effectors in CF patients.
An efficient centralized scheduling algorithm for IEEE 802.16 multi-radio mesh networks

In centralized scheduling for IEEE 802.16 mesh networks, all packets should be transported through the BS (Base Station). The links to or from the BS become the system's bottleneck and the throughput is heavily impacted by the interference. To solve this problem, multiple radios are equipped in some stations to increase the bandwidth of these links. This paper proposes a new efficient scheduling algorithm for IEEE 802.16 mesh mode. It is a centralized scheduling algorithm that considers the usage of multiple radios. Extensive simulation results obtained from different configurations are presented. The result shows that our algorithm has improved the system performance in the aspects of scheduling length, transmission delay, channel utilization ratio and system throughput.
DOBBS: Towards a Comprehensive Dataset to Study the Browsing Behavior of Online Users

The investigation of the browsing behavior of users has been a topic of active research since the Web started. However, new online services changed the meaning behind "browsing the Web" and require a fresh look at the problem. Platforms such as YouTube or last. Fm have started to replace the traditional media channels (cinema, television, radio) and media distribution formats (CD, DVD, Blu-ray). Particularly social networks (e.g., Facebook) attracted whole new, particularly less tech-savvy audiences. Advances in mobile technologies made browsing "on-the-move" the norm and changed the user behavior, often being influenced by the user's location and context in the physical world. Commonly used datasets, such as web server access logs or search engines transaction logs, are inherently not capable of capturing the browsing behavior of users in all these facets. DOBBS (DERI Online Behavior Study) is an effort to create such a dataset in a non-intrusive, completely anonymous and privacy-preserving way. DOBBS provides a browser add-on which keeps track of users' browsing behavior. In this paper, we outline the motivation behind DOBBS, describe the add-on and dataset, and present some first results to highlight the strengths of DOBBS.
Nitrification and denitrification in the rhizosphere of the aquatic macrophyte Lobelia dortmanna L.

Nitrogen and O2 transformations were studied in sediments covered by Lobelia dortmanna L. ; a combination of 15N isotope pairing and microsensor (O2, NO3−, and NH4+) techniques were used. Transformation rates and microprofiles were compared with data obtained in bare sediments. The two types of sediment were incubated in doublecompartment chambers connected to a continuous flow‐through system.
Group locality preserving orthogonal nonnegative matrix factorization

Non-negative matrix factorization (NMF) is useful in finding basis information of non-negative data. It is a new dimension reduction method. In this paper, a Group Locality Preserving Orthogonal Nonnegative Matrix Factorization (GLPONMF) is investigated. The idea is to extend the NMF method in order to extract basis vectors for each sample class and at the same time enforce the locality preserving orthogonal properties. Finally, the experimental evaluation has been given.
An Evaluation of Interactive Map Comparison Techniques

Geovisualization applications typically organize data into layers. These layers hold different types of geographical features, describe different characteristics of the same features, or represent those features at different points in time. Layers can be composited in various ways, most often employing a juxtaposition or superimposition strategy, to produce maps that users can explore interactively. From an HCI perspective, one of the main challenges is to design interactive compositions that optimize the legibility of the resulting map and that ease layer comparison. We characterize five representative techniques, and empirically evaluate them using a set of real-world maps in which we purposefully introduce six types of differences amenable to inter-layer visual comparison. We discuss the merits of these techniques in terms of visual interference, user attention and scanning strategy. Our results can help inform the design of map-based visualizations for supporting geo-analysis tasks in many application areas.
Pulmonary macrophage function during experimental cytomegalovirus interstitial pneumonia

Since cytomegalovirus (CMV) infections may alter host defense against a variety of pathogens, phagocytosis, oxygen uptake, and H2O2 release by pulmonary macrophages obtained from guinea pigs with acute CMV interstitial pneumonia were evaluated. Experimental animals were inoculated subcutaneously on day zero with 10(7.5) 50% tissue culture infective doses of virulent guinea pig CMV. Control animals received an uninfected salivary gland suspension. The animals were sacrificed on day 7; the tissues were cocultivated for virus isolation, and the lungs were lavaged to obtain pulmonary macrophages. CMV was isolated from buffy coat cells (96%), bone marrow cells (71%), whole lungs (77%), pulmonary macrophages (60%), and pulmonary granulocytes (49%). There was no significant difference between groups at sacrifice in the total number of macrophages obtained by pulmonary lavage or in the phagocytic activity of the macrophages in vitro. However, in CMV-infected animals, the maximum rates of O2 consumption in response to the soluble stimulus, phorbol myristate acetate, and the particulate stimulus, Staphylococcus aureus, were 47 and 55%, respectively, of the rates in uninfected controls. Total macrophage O2 consumption in CMV-infected animals was 32 and 37%, respectively, of control values in response to the same stimuli. In CMV-infected animals, the maximum rates of H2O2 release were 22% of those in simultaneous controls for both stimuli, and total H2O2 release was 30 and 25%, respectively, of that in controls in response to these stimuli. Such alterations in macrophage oxidative function may contribute to superinfection during CMV pneumonia.
Universal manifold pairings and positivity

Gluing two manifolds M1 and M2 with a common boundary S yields a closed manifold M. Extending to formal linear combinations x = �aiMi yields a sesquilinear pairing p = h , i with values in (formal linear combinations of) closed manifolds. Topological quantum field theory (TQFT) represents this universal pairing p onto a finite dimensional quotient pairing q with values in C which in physically motivated cases is positive definite. To see if such a “unitary” TQFT can potentially detect any nontrivial x, we ask if h x, xi 6 = 0 whenever x 6 0. If this is the case, we call the pairing p positive. The question arises for each dimension d = 0,1,2, . We find p(d) positive for d = 0,1, and 2 and not positive for d = 4. We conjecture that p(3) is also positive. Similar questions may be phrased for (manifold, submanifold) pairs and manifolds with other additional structure. The results in dimension 4 imply that unitary TQFTs cannot distinguish homotopy equivalent simply connected 4–manifolds, nor can they distinguish smoothly s–cobordant 4–manifolds. This may illuminate the difficulties that have been met by several authors in their attempts to formulate unitary TQFTs for d = 3 + 1. There is a further physical implication of this paper. Whereas 3–dimensional Chern– Simons theory appears to be well-encoded within 2–dimensional quantum physics, e.g. in the fractional quantum Hall effect, Donaldson–Seiberg–Witten theory cannot be captured by a 3–dimensional quantum system. The positivity of the physical Hilbert spaces means they cannot see null vectors of the universal pairing; such vectors must map to zero. AMS Classification numbers Primary: 57R56, 53D45 Secondary: 57R80, 57N05, 57N10, 57N12, 57N13
Serine one-carbon catabolism with formate overflow

Serine catabolism results in formate efflux that exceeds anabolic demands for purine synthesis. Serine catabolism to glycine and a one-carbon unit has been linked to the anabolic requirements of proliferating mammalian cells. However, genome-scale modeling predicts a catabolic role with one-carbon release as formate. We experimentally prove that in cultured cancer cells and nontransformed fibroblasts, most of the serine-derived one-carbon units are released from cells as formate, and that formate release is dependent on mitochondrial reverse 10-CHO-THF synthetase activity. We also show that in cancer cells, formate release is coupled to mitochondrial complex I activity, whereas in nontransformed fibroblasts, it is partially insensitive to inhibition of complex I activity. We demonstrate that in mice, about 50% of plasma formate is derived from serine and that serine starvation or complex I inhibition reduces formate synthesis in vivo. These observations transform our understanding of one-carbon metabolism and have implications for the treatment of diabetes and cancer with complex I inhibitors.
Newcastle University E-prints Citation for Published Item: Further Information on Publisher Website: Publishers Copyright Statement: Use Policy: Characterisation of the Bold Response Time Course at Different Levels of the Auditory Pathway in Non-human Primates

A. Characterisation of the BOLD response time course at different levels of the auditory pathway in non-human primates. Neuroimage 2010. The full-text may be used and/or reproduced and given to third parties in any format or medium, without prior permission or charge, for personal research or study, educational, or not for profit purposes provided that: • A full bibliographic reference is made to the original source • A link is made to the metadata record in Newcastle e-prints • The full text is not change in any way. The full-text must not be sold in any format or medium without the formal permission of the copyright holders. Abstract Non-human-primate fMRI is becoming increasingly recognised as the missing link between the widely applied methods of human imaging and intracortical animal electrophysiology. A crucial requirement for the optimal application of this method is the precise knowledge of the time course of the Blood Oxygenation Level Dependent (BOLD) signal. We mapped the BOLD signal time course in the inferior colliculus (IC), medial geniculate body (MGB) and in tonotopically defined fields in the auditory cortex of two macaques. The results show little differences in the BOLD-signal time courses within the auditory pathway. However, we observed systematic differences in the magnitude of the change in the BOLD signal with significantly stronger signal changes in field A1 of the auditory cortex compared to field R. The measured time course of the signal was in good agreement with similar studies in human auditory cortex but showed considerable differences to data reported from macaque visual cortex. Consistent with the studies in humans, we measured a peak in the BOLD response around 4 seconds after the onset of 2-s broadband noise stimuli while previous studies recorded from the primary visual cortex of the same species reported the earliest peaks to short visual stimuli several seconds later. The comparison of our results with previous studies does not support differences in haemodynamic responses within the auditory system between human and non-human primates. Furthermore, the data will aid optimal design of future auditory fMRI studies in non-human primates.
Towards Container Orchestration in Fog Computing Infrastructures

The Cloud Computing paradigm promoted the outsourcing of IT infrastructure and enterprise applications paving the way to save costs of building and maintaining computing infrastructures on-premise. In this environment, scale up of applications to attend demands in high peaks become easier and highly automated. Virtualization was a key technology to enable these characteristics. Nowadays, Container technology became popular as an alternative to Virtual Machines, and is being widely applied, as a consequence, Orchestration tools are being extensively applied in the Cloud environment. Despite its success, when it comes to the Internet of Things (IoT), Cloud Computing falls short to meet several requirements. Fog Computing appear as a complimentary technology to the Cloud to deliver the missing requirements in the IoT scene. Managing services deployed in a Fog Environment is a complex task and infrastructure management and orchestration tools can make it seamless. In this paper, we evaluate how Containers can affect the overall performance of applications in Fog Nodes. We analyze different Container Orchestration tools and how they meet Fog requirements to run applications. We also propose a Container Orchestration Framework for Fog Computing infrastructures.
HEME OXYGENASE-DERIVED ENDOGENOUS CARBON MONOXIDE IMPAIRS FLOW-INDUCED DILATION IN RESISTANCE VESSELS

Vascular tissues normally express heat shock protein 32 (heme oxygenase [HO] 1), which degrades heme. A product of this reaction, carbon monoxide (CO), has been shown to promote relaxation of vascular smooth muscle, but it also inhibits NOS. Because flow-induced dilation is dependent upon the formation of endothelium-derived NO, we conducted the current study to determine if HO-mediated formation of CO impairs flow-induced dilation. In isolated pressurized first-order gracilis muscle arterioles, proximal and distal pressures were manipulated to generate intraluminal flows of 0 to 50 &mgr;L/min at a constant vascular midline pressure of 80 ± 1 mmHg. Vehicle-treated vessels displayed flow-related vasodilation, which was abolished by a NOS inhibitor, N&ohgr;-nitro-L-arginine methyl ester. Acute intraluminal pretreatment with an inhibitor of HO, chromium mesoporphyrin (CrMP), enhanced flow-induced responses in similarly prepared vessels. In contrast, a substrate for heme formation that drives CO generation, &dgr;-aminolevulinic acid, abolished flow-induced dilation in a manner which could be fully prevented and reversed by CrMP. In addition, the HO product biliverdin had no effect on flow-induced dilation, whereas the responses were abolished by exogenous CO. Furthermore, spontaneous generation of CO was measured in isolated vascular segments to confirm that &dgr;-aminolevulinic acid increased carbon formation by 29%, whereas CrMP reduced it by 43%. These data show flow-induced dilation can be impaired by a HO product, and that the impairment was not produced by biliverdin but is mimicked by CO. These results suggest that the HO-generated CO attenuates flow-induced dilation in the vasculature and, accordingly, may contribute to vascular dysfunction after injury.