Miracle-dz/UniFAR-FTUs huggingface dataset:
Association of Low Concentrations of Serum Mannose-Binding Protein with Recurrent Infections in Adults

ABSTRACT Low concentrations of mannose-binding protein (MBP; also known as mannose-binding lectin) are associated with common opsonic defect in immunodeficient children. We compared the concentrations of MBP in the sera of 47 adults with non-human immunodeficiency virus-related recurrent infections (group I) and 50 healthy adult controls. Mean serum MBP concentrations in the patient group did not differ significantly from those in the control group (P < 0.4). Nevertheless, the proportion of individuals with less than 5 ng of serum MBP per ml was significantly larger in the patient group (21%, P = 0.01) than in the control group (4%). Group II consisted of 73 pediatric and 56 adult patients with recurrent infections. Pediatric patients had significantly lower mean concentrations of serum MBP than their controls (P < 0.005), and there was no significant difference between the concentrations in sera of adult patients and adult controls (P < 0.4). Again, the proportion of individuals with less than 5 ng of serum MBP per ml was significantly larger in both pediatric (22%, P = 0.045) and adult (38%,P = 0.000016) patients than in their respective controls (4%). Our results demonstrate that, as in children, low concentrations of serum MBP can be associated with recurrent infections in adults.
Sliding-Mode Output Feedback Control Design

We consider the sliding-mode output feedback controller (SMOFC) design problem for a class of uncertain multivariable systems. We first design a stabilizing SMOFC for matched uncertain systems. Using linear matrix inequalities (LMIs), we derive a necessary and sufficient condition for the existence of a linear sliding surface depending on outputs and compensator states. Using the solution of the LMI existence condition, we characterize the gain matrices. We give the nonlinear switching feedback gain guaranteeing the reachability condition. Second, we give an LMI-based design method to combine various useful performance criteria which can be used to guarantee a desired robust performance in spite of mismatched uncertainties. The performance criteria include alpha-stability, LQ performance, H 2/H infin performance, and peak-to-peak gain bound. In particular, we show that by including H infin performance constraints, we can easily solve the SMOFC design problem for challenging system models to which the previous methods are not easily applicable. Finally, we give a numerical design example showing that our method can be successfully applied to the problem of designing reduced-order SMOFCs for uncertain time-delay systems or mismatched uncertain systems.
Comparative study between the effects of dexmedetomidine and propofol on cerebral oxygenation during sedation at pediatric cardiac catheterization

Introduction: Nowadays, assessment of brain oxygen saturation, which is simply appliable and noninvasive method, can provide the anesthesia plans to be optimized according to the needs of the brain, which is the main target organ. Brain may be exposed to hypoxia due to supply-demand imbalance of oxygen not only in general anesthesia procedures but also in sedation practices. The aim of the study is to compare the effects of dexmedetomidine and propofol which are widely used agents for pediatric catheterization procedures on brain oxygen saturation using Fore-Sight. Material and Methods: A total of 44 patients undergoing diagnostic cardiac catheterization between 1 and 18 years old were included in the study. All patients, who were randomly divided into two groups, had ASA physical status I-II. In Group Propofol (Group P, n = 22),induction of sedation was made by midazolam (0.5 mg,iv) + propofol (1m/kg,iv), and in Group Dexmedetomidine (Group D, n = 22), induction of sedation was made by midazolam (0.5 mg,iv) +dexmedetomidine (1mcg/kg, iv). Throughout the sedation, cerebral tissue oxygen saturation (SctO 2 ) was recorded by Fore-Sight in addition to routine monitoring. Results: There were no statistically significant differences between the groups in terms of demographic data, hemodynamic data and sedation scores. On other hand, statistically significant decreases in cerebral tissue oxygen saturation were detected especially at 5th and 10th minutes, in Group D, while cerebral oxygenation level did not decrease in Group P. Though, statistically significant difference was determined between two groups in terms of cerebral oxygen saturation, the obtained data was not interpreted as cerebral desaturation. Conclusion: As a conclusion, there was a statistically significant but clinically insignificant decrease in cerebral tissue oxygen saturation in dexmedetomidine group compared to propofol group. Although it does not seem to be important in hemodynamic stabilization, we assume that may cause problems for clinically unstable patients.
Introduction: Resilience of cancer survivors across the lifespan

Received June 15, 2005; accepted June 27, 2005. In 2001 the National Cancer Institute’s (NCI) Office of Cancer Survivorship and the American Cancer Society’s (ACS) Behavioral Research Center forged a new partnership to champion the growing field of cancer survivorship research. As part of this partnership, the NCI and ACS made a commitment to co-sponsor biennial scientific conferences that would bring together investigators, clinicians, and advocates engaged in conducting or promoting research among individuals who had undergone treatment for cancer and their families. The first of these meetings was held June 2– 4, 2002, in Washington, DC. On Sunday, June 2nd, a date recognized as National Cancer Survivor’s Day, a Town Hall meeting was held preceding the conference, which engaged more than 100 community participants. This activity, supported by the National Coalition for Cancer Survivorship and telecast on the ACS website, provided the “human face and voice” to the 2 days of scheduled scientific meetings that followed. This supplement to Cancer contains the expanded, peer-reviewed articles of most of the scientific talks given at this historic event. Due to advances in early detection, treatment, and supportive care, the 5-year survival rate for adults diagnosed with cancer is now 64%. This figure is even higher for those diagnosed as children, 75% of whom can expect to be alive at 10 years. As of 2002 (the year for which the most current figures are available), it was estimated that there were more than 10 million survivors of cancer in the U.S. alone, and greater than 24 million survivors worldwide. As advances in cancer control diffuse into the community, the rate of those dying prematurely of heart disease continues to decline and, with the aging of the world’s population, the number of individuals diagnosed with and surviving long-term with a history of cancer will continue to grow into the foreseeable future. Early psychosocial and behavioral research among cancer survivors who had undergone treatment sought to document the diverse effects of the disease and its treatment on these survivors’ lives and those of their families. These studies made it clear that being disease free did not mean being free of the disease. Cancer has the capacity to touch all aspects of an individual’s health: physical, functional, psychological/cognitive, social, economic, and spiritual. In talking with and listening to the accounts of hundreds of cancer survivors, researchers also learned that despite experiencing catastrophic events at times, many cancer survivors manifest remarkable resilience in the face of illness. It was in recognition of this new focus in survivorship research that the NCI and ACS planning committee members chose “Resilience Across the Lifespan” as the theme for their first co-sponsored Biennial Cancer Survivorship Research Conference. 2543
Molecular distinction of circulating pregnancy-associated plasma protein A in myocardial infarction and pregnancy.

BACKGROUND In the blood of pregnant women, pregnancy-associated plasma protein A (PAPP-A) is present as a covalent complex with the proform of eosinophil major basic protein (proMBP). Recently, increased serum concentrations of PAPP-A have been found in acute coronary syndromes (ACS). The aim of this study was to investigate whether the circulating PAPP-A in ACS is the same as that in pregnancy. METHODS We developed two time-resolved immunofluorometric assays based on a relative epitope map constructed by the use of 17 monoclonal antibodies. One assay, which measured total PAPP-A, used two PAPP-A subunit-specific antibodies. The other assay, which measured PAPP-A/proMBP complex, used one proMBP subunit-specific antibody and one PAPP-A subunit-specific antibody. Serum samples from four patients with myocardial infarction (MI), three pregnant women in their first trimester, and one in her third trimester were fractionated by gel filtration on a Superose 6 precision column. The two assays were used to analyze fractions obtained by gel filtration as well as serum samples serially collected from four other MI patients. RESULTS Pregnancy-related PAPP-A was eluted as a single peak with a molecular mass of approximately 700 kDa, whereas ACS-related PAPP-A was also eluted as a single peak but with a molecular mass of approximately 530 kDa. Pregnancy-related PAPP-A was detected equally by the two assays, whereas increased ACS-related PAPP-A was detected only by the assay for total PAPP-A. CONCLUSIONS Our results provide the first evidence that circulating ACS-related PAPP-A is different from circulating pregnancy-related PAPP-A in that it is not complexed with proMBP. These findings provide a solid foundation for the design of immunoassays to accurately measure atherosclerosis-associated plasma protein A in the circulation.
The effect of 6‐dimethylaminopurine (6‐DMAP) and cycloheximide (CHX) on the development and chromosomal complement of sheep parthenogenetic and nuclear transfer embryos

The effects of activation by 6‐dimethylaminopurine (6‐DMAP) and cycloheximide (CHX) on the development and chromosomal complement of sheep parthenogenetic and SCNT embryos were investigated. The results revealed that the blastocyst development of parthenogenetic embryos was significantly higher (P < 0.05) in 6‐DMAP activated oocytes, compared to those activated with CHX (21.0 ± 0.9 vs. 14.9 ± 0.5, respectively). In contrast, the blastocyst frequencies did not significantly differ (P > 0.05) between the two activation treatment groups for SCNT embryos. The 6‐DMAP or CHX treatment did not result in any significant difference in the blastocyst total cell number in either parthenote or SCNT embryos. The chromosomal analysis revealed that all the parthenogenetic embryos (100.0%) derived from 6‐DMAP treatment, were chromosomally abnormal whereas in CHX‐treated embryos, it was significantly lowered (93.6%, P < 0.05). Conversely, the proportions of chromosomally abnormal SCNT embryos did not significantly differ (P > 0.05) among the 6‐DMAP and CHX‐ treated embryo groups (60.0% vs. 56.2%, respectively). This study demonstrated that oocyte activation agents such as DMAP and CHX have differing effects on meiotic or mitotic nuclei. The study also highlighted the feasibility of using bovine X and Y chromosome specific painting probes in sheep embryos. Mol. Reprod. Dev. © 2005 Wiley‐Liss, Inc.
Increase of MMP-13 expression in multi-stage oral carcinogenesis and epigallocatechin-3-gallate suppress MMP-13 expression.

BACKGROUND Matrix metalloproteinases (MMPs) play pivotal roles in tumor progression. MMP-13 (collagenase-3) digests collagen and other extracellular components. MATERIALS AND METHODS Reverse transcriptase-polymerase chain reaction (RT-PCR), immunohistochemistry and zymograph were used to study the roles of MMP-13 during the neoplastic process of oral squamous cell carcinoma (OSCC). RESULTS Increase of MMP-13 mRNA and protein expression in OSCC cell lines relative to cultivated normal oral keratinocytes was found. MMP-13 mRNA expression in OSCC was significantly higher than in non-cancerous match tissue (NCMT) in 36 tissue pairs. Esophageal squamous cell carcinoma also exhibited high MMP-13 mRNA expression. The percentage of OSCC exhibiting strong MMP-13 immunoreactivity was significantly higher than pre-invasive lesion and NCMT. Treatment with >5 microm epigallocatechin-3-gallate (EGCG) to OEC-M1 cells suppressed the expression and activity of MMP-13. CONCLUSION MMP-13 could be a potential tumor marker for OSCC. The effects of EGCG in tumor inhibition may act partially through the modulation of MMP-13.
Influence of gastrointestinal (GI) hormones on suckling, gastric emptying and pancreatic trypsin content in the developing rat.

UNLABELLED Aim of this study was to investigate how gastrointestinal hormones such as exogenous s.c. caerulein (6 micrograms/kg body weight), secretin (100 U/kg body weight), bombesin (20 micrograms/kg body weight, s.c.), CCK-8 (10 micrograms/kg body weight, i.p.), the CCK-A receptor antagonist L 364,718 (100 micrograms/kg body weight, i.p.), camostate (400 mg/kg body weight per os) which releases endogenous CCK and the coadministration of camostate with atropin (250 micrograms/kg body weight, s.c) or L 364,718 (1 mg/kg) influence milk intake from nipples, gastric emptying, and discharge of pancreatic trypsin content in 10-day-old rat pups. Saline-treated pups served as controls. The non-fasting Wistar rat pups of both sexes were used in littermate order. The suckling lasted for 30 and 45 min, respectively. One pup was used only once. After suckling the pups were decapitated, their stomach and pancreas were removed and weighed. The gastric food content was regarded as intake of milk and expressed as difference between the filled minus empty stomach. Pancreatic trypsin and protein content, plasma CCK level were measured. The exogenous agents did not influence gastric content. The investigated peptides decreased, L 364,718, however, increased the pancreatic trypsin/protein ratio. Camostate increased gastric content by 60% and decreased pancreatic trypsin/protein ratio vs saline by 90%. The gastric and pancreatic effects of camostate were not reversed by atropine or L 364,718. CONCLUSION Exogenous and endogenous CCK seem not to influence milk intake while decrease pancreatic trypsin/protein ratio. However, endogenous CCK inhibit gastric emptying. The plasma CCK level was elevated due to the applied CCK-8 and camostate during the observed suckling period.
Analysis of sum-product decoding of low-density parity-check codes using a Gaussian approximation

Density evolution is an algorithm for computing the capacity of low-density parity-check (LDPC) codes under message-passing decoding. For memoryless binary-input continuous-output additive white Gaussian noise (AWGN) channels and sum-product decoders, we use a Gaussian approximation for message densities under density evolution to simplify the analysis of the decoding algorithm. We convert the infinite-dimensional problem of iteratively calculating message densities, which is needed to find the exact threshold, to a one-dimensional problem of updating the means of the Gaussian densities. This simplification not only allows us to calculate the threshold quickly and to understand the behavior of the decoder better, but also makes it easier to design good irregular LDPC codes for AWGN channels. For various regular LDPC codes we have examined, thresholds can be estimated within 0.1 dB of the exact value. For rates between 0.5 and 0.9, codes designed using the Gaussian approximation perform within 0.02 dB of the best performing codes found so far by using density evolution when the maximum variable degree is 10. We show that by using the Gaussian approximation, we can visualize the sum-product decoding algorithm. We also show that the optimization of degree distributions can be understood and done graphically using the visualization.
Intraocular CNTF reduces vision in normal rats in a dose-dependent manner.

PURPOSE CNTF is a neuroprotective agent for retinal degenerations that can cause reduced electroretinogram (ERG) amplitudes. The goal of the present study was to determine the effects of intraocular delivery of CNTF on normal rat visual function. METHODS Full-field scotopic and photopic ERG amplitudes and spatial frequency thresholds of the optokinetic response (OKR) of adult Long-Evans rats were measured before and after intravitreous injection of CNTF or subretinal delivery of adenoassociated virus-vectored CNTF (AAV-CNTF) into one eye. Visual acuity was also measured by using the Visual Water Task in AAV-CNTF-injected animals. Multiunit luminance thresholds were recorded in the superior colliculus after CNTF injection, and the eyes were examined histologically. RESULTS In eyes injected with a high dose of CNTF, ERG amplitudes and OKR thresholds measured through CNTF-injected eyes were decreased by 45% to 70% within 6 days after injection. ERG amplitudes had begun to recover by 21 days, whereas OKR thresholds only began to recover after 56 days. Neither OKR thresholds nor ERG amplitudes fully recovered until 90 to 100 days. When measured in the superior colliculus at 2 weeks after CNTF injection, luminance thresholds were elevated by 0.35 log units. In AAV-CNTF-injected eyes, OKR thresholds, and visual acuity were reduced by approximately 50% for at least 6 months, and scotopic and photopic ERG b-waves were reduced by 30% to 50%. Photoreceptor loss occurred in the injected regions in some of the eyes. By contrast, comparison of dose-response analysis with a dose-response study of light damage strongly suggests that therapeutic doses of CNTF exist that do not suppress ERG responses. CONCLUSIONS Intraocular delivery of CNTF, which preserves photoreceptors in animal models of retinal degeneration, impairs visual function in normal rats at very high doses, but not at lower doses that still provide protection from constant light damage.
Randomised comparison of two neonatal resuscitation bags in manikin ventilation

Objective To compare ventilation properties and user preference of a new upright neonatal resuscitator developed for easier cleaning, reduced complexity, and possibly improved ventilation properties, with the standard Laerdal neonatal resuscitator. Design Eighty-seven Tanzanian and Norwegian nursing and medical students without prior knowledge of newborn resuscitation were briefly trained in bag-mask ventilation. The two resuscitators were used in random order on a manikin connected to a test lung with normal or low lung compliance. Data were collected with the Laerdal Newborn Resuscitation Monitor. The students graded mask seal and ease of air entry on a four-point scale ranging from 1 (‘difficult’) to 4 (‘easy’) and stated which device they preferred. (Equipment from Laerdal Global Health and Laerdal Medical). Results For upright versus standard resuscitator and normal lung compliance, mean expiratory lung volume was 15.5 mL vs 13.9 mL (p=0.001), mean mask leakage 48% vs 58% (p<0.001), and mean airway pressure 20 cm H2O vs 19 cm H2O (p=0.003), respectively. For low lung compliance, mean expiratory lung volume was 8.6 mL vs 8.1 mL (p=0.045), mean mask leakage 53% vs 62% (p<0.001), and mean airway pressure 21 cm H2O vs 20 cm H2O (p=0.004) for upright versus standard. The upright resuscitator was preferred by 82% and 68% of students during ventilation with normal and low lung compliance, respectively (p=0.001). Conclusions Expiratory volumes were higher, mask leakage lower, and mean airway pressure slightly higher with upright versus standard resuscitator when ventilating a manikin. The majority of students preferred the upright resuscitator.
Crowd-sourcing NLG Data: Pictures Elicit Better Data.

Recent advances in corpus-based Natural Language Generation (NLG) hold the promise of being easily portable across domains, but require costly training data, consisting of meaning representations (MRs) paired with Natural Language (NL) utterances. In this work, we propose a novel framework for crowdsourcing high quality NLG training data, using automatic quality control measures and evaluating different MRs with which to elicit data. We show that pictorial MRs result in better NL data being collected than logic-based MRs: utterances elicited by pictorial MRs are judged as significantly more natural, more informative, and better phrased, with a significant increase in average quality ratings (around 0.5 points on a 6-point scale), compared to using the logical MRs. As the MR becomes more complex, the benefits of pictorial stimuli increase. The collected data will be released as part of this submission.
Adoption and Diffusion of Telemedicine Technology in Health Care Organizations: A Comparative Case Study in Hong Kong

Rapidly changing dynamics and turbulence in the business environment have made technology management increasingly critical to the bottom-line survival and competitiveness of many organizations. Adoption and diffusion are 2 challenging technology management issues facing health care organizations. As health care is becoming an increasingly important sector of the national and the global economy, contemporary problems in access, equality, and costs have demanded innovativeness from health care organizations that, in response need to adopt and institutionalize appropriate technological innovations for service improvement and expansion. A case in point is telemedicine technology that has the potential to support physicians' patient care and improve health care organizations' competitiveness.
Autosomal dominant pure spastic paraplegia: a clinical, paraclinical, and genetic study

OBJECTIVES At least three clinically indistinguishable but genetically different types of autosomal dominant pure spastic paraplegia (ADPSP) have been described. In this study the clinical, genetic, neurophysiological, and MRI characteristics of ADPSP were investigated. METHODS Sixty three at risk members from five families were clinically evaluated. A diagnostic index was constructed for the study. Microsatellite genotypes were determined for chromosomes 2p, 14q, and 15q markers and multipoint linkage analyses were performed. Central motor conduction time studies (CMCT), somatosensory evoked potential (SSEP) measurement, and MRI of the brain and the total spinal cord were carried out in 16 patients from four families. RESULTS The clinical core features of ADPSP were homogeneously expressed in all patients but some features were only found in some families and not in all the patients within the family. In two families non-progressive “congenital” ADPSP was seen in some affected members whereas adult onset progressive ADPSP was present in other affected family members. As a late symptom not previously described low backache was reported by 47%. Age at onset varied widely and there was a tendency for it to decline in successive generations in the families, suggesting anticipation. Genetic linkage analysis confined the ADPSP locus to chromosome 2p21-p24 in the five families. The lod scores obtained by multipoint linkage analysis were positive with a combined maximum lod score of Z=8.60. The neurophysiological studies only showed minor and insignificant prolongation of the central motor conduction time and further that peripheral conduction and integrity of the dorsal columns were mostly normal. Brain and the total spinal cord MRI did not disclose any significant abnormalities compared with controls. CONCLUSIONS ADPSP linked to chromosome 2p21-p24 is a phenotypic heterogeneous disorder characterised by both interfamilial and intrafamilial variation. In some families the disease may be “pure” but the existence of “pure plus” families is suggested in others. The neurophysiological and neuroimaging investigations did not show any major abnormalities.