Miracle-dz/UniFAR-FTUs huggingface dataset:
Multiple Conditions Increase Preventable Crash Risks Among Truck Drivers in a Cohort Study

Objective: This study aims to quantify the crash risk for truck drivers with multiple comorbid medical conditions, after adjusting for confounders. Methods: This retrospective cohort of 38,184 drivers evaluated concomitant medical conditions and subsequent crash data between January 1, 2005, and October 31, 2012. Hazard ratios (HRs) and 95% confidence intervals (95% CIs) were calculated for any cause and preventable crashes of varying severity. Results: Drivers with three or more medical conditions had a significantly increased risk of preventable Department of Transportation (DOT) reportable crashes (HR = 2.53, 95% CI = 1.65 to 3.88) and preventable crashes with injuries (HR = 2.23, 95% CI = 1.09 to 5.31) after adjustment for covariates. Similarly, adjusted HRs were 2.55 (95% CI = 1.37 to 4.73) for any cause DOT-reportable crashes and 3.21 (95% CI = 1.18 to 8.75) for any cause crashes with injuries. Conclusions: Having three concomitant medical conditions may be a statistically significant risk factor for preventable and any cause DOT-reportable crashes and crashes with injuries.
IL-37 suppresses hepatocellular carcinoma growth by converting pSmad3 signaling from JNK/pSmad3L/c-Myc oncogenic signaling to pSmad3C/P21 tumor-suppressive signaling

IL-37 has been characterized as a fundamental inhibitor of innate immunity and a tumor suppressor in several cancers. However, the molecular mechanism of IL-37 in hepatocellular carcinoma (HCC) is largely unclear. In this study we found IL-37 expression was down-regulated in human HCC tissues and cell lines, and was negatively correlated with tumor size, vascular invasion, as well as overall-survial and disease-free survival (OS and DFS) of HCC. Multivariate Cox analysis revealed that IL-37 was an independent prognostic indicator for OS and DFS in HCC. Functional studies further showed that IL-37 overexpression significantly suppressed tumor growth by confining HCC to G2/M cell cycle arrest in vitro and in vivo. Mechanistically, we determined that IL-37 promoted Smad3 phospho-isoform signaling conversion from JNK/pSmad3L/c-Myc oncogenic signaling to pSmad3C/p21 tumor-suppressive signaling. Consistently, we detected a significant negative correlation between IL-37 expression and pSmad3L levels in a cohort of HCC biopsies; and the expression of pSmad3L predicted poorer outcome. These data highlight the importance of IL-37 in the cell proliferation and progression of HCC, and suggests that IL-37 may be a valuable biomarker for HCC prognosis.
Modeling Partisan Media Effects in the 2014 U.S. Midterm Elections

This study tested partisan media effects in the 2014 U.S. midterm elections. A survey was distributed to 992 residents of Georgia, Iowa, and North Carolina. A novel multigroup latent variable structural equation model tested the direct, indirect, and conditional effects of political interest, partisan media use, political information efficacy, and partisanship on affective polarization. Findings demonstrated a polarizing effect of pro-partisan media, a depolarizing effect of cross-cutting media, and an indirect effect of political interest on polarization through partisan media use. There was no evidence that the effects of partisan media were mediated through political confidence or moderated by partisanship.
Syllable structure, syllable duration and final lengthening in Parkinsonian French speech

The present study investigates the duration of syllables with relation to position within phrases and the pattern of segment omissions within syllables in a text read by 12 French PD patients and 12 French control subjects. Three main tendencies emerged. The first was similar duration of syllables in PD and control speech, which may result from a combination of articulatory undershoot and slowness of speech gestures. The second was a normal incidence of segment omissions in both groups: these were mostly coda consonants and/or the second member of C1C2 sequences. The third was a normal production and a strong correlation of final lengthening with the syntactic structure of sentences in both PD speech and control speech. Having analysed the results the study evaluates their implication with respect to the role of basal ganglia in the production of speech.
Stability of lutein encapsulated whey protein nano-emulsion during storage

Lutein is a hydrophobic carotenoid that has multiple health functions. However, the application of lutein is limited due to its poor solubility in water and instability under certain conditions during storage. Hereby we generated lutein loaded nano-emulsions using whey protein isolate (WPI) or polymerized whey protein isolate (PWP) with assistance of high intensity ultrasound and evaluate their stability during storage at different conditions. We measured the particle size, zeta-potential, physical stability and lutein content change. Results showed that the PWP based nano-emulsion system was not stable in the tested Oil/Water/Ethanol system indicated by the appearance of stratification within only one week. The WPI based nano-emulsion system showed stable physiochemical stability during the storage at 4°C. The lutein content of the system was reduced by only 4% after four weeks storage at 4°C. In conclusion, our whey protein based nano-emulsion system provides a promising strategy for encapsulation of lutein or other hydrophobic bioactive molecules to expand their applications.
Pharmacological or transcriptional inhibition of both HDAC1 and 2 leads to cell cycle blockage and apoptosis via p21Waf1/Cip1 and p19INK4d upregulation in hepatocellular carcinoma

Histone deacetylases (HDACs) are commonly dysregulated in cancer and represent promising therapeutic targets. However, global HDAC inhibitors have shown limited efficacy in the treatment of solid tumours, including hepatocellular carcinoma (HCC). In this study, we investigated the therapeutic effect of selectively inhibiting HDAC1 and 2 in HCC.
Task-centric holistic agile approach on teaching cyber physical systems engineering

Context: Cyber physical systems are getting pervasive in our every-day life. For their development the industry needs highly-qualified and skilled employees. The employees need to have a wide breadth of knowledge in many engineering disciplines and possess excellent soft skills. Ideally, the needed skills are taught in practical settings. Problem: The versatility of the problems in development of cyber physical systems poses a challenge for the teaching. A common approach to teaching software engineering concepts is to have students form teams to create a software product; this allows them to experience the problems first hand. However, this approach, compared with "traditional" software engineering and software development, is much more difficult for cyber-physical systems, due to the need to have a wide understanding in multiple engineering fields. At the same time, the education of engineering concepts lack on teaching of soft skills that are often key success factors for engineering projects. Approach: We developed a novel task-centric holistic agile approach on teaching cyber physical systems. The concept is task-centric concluding five teaching approaches that may be used when needed. The concept focuses the teaching of technical skills and soft skills. Result: The proposed concept allows students to have an insight into the difficulties involved in development of cyberphysical systems from multiple points of view in a realistic way. Conclusion: The holistic agile approach on teaching cyber physical systems has the potential to reinforce conceptual instruction with hands-on learning at a fraction of the time and cost that would be required to run a true cyber-physical systems development project.
Multi‐site Cooperativity in Alkali‐Metal‐Exchanged Faujasites for the Production of Biomass‐Derived Aromatics

Abstract The catalytic Diels–Alder cycloaddition–dehydration (DACD) reaction of furanics with ethylene is a promising route to bio‐derived aromatics. The reaction can be catalyzed by alkali‐metal‐exchanged faujasites. Herein, the results of periodic DFT calculations based on accurate structural models of alkali‐metal‐exchanged zeolites are presented, revealing the fundamental roles that confinement and the nature of the exchangeable cations in zeolite micropores have in the performance of faujasite‐based catalysts in the DACd reaction. Special attention is devoted to analyzing the effect of functional substituents on furanic substrates (furan, 2,5‐dimethylfuran, 2,5‐furandicarboxylic acid) on the catalyst behavior. It is demonstrated that the conventional reactivity theories of the Diels–Alder chemistry based on simplistic single‐site Lewis acidity and substituent effects do not apply if catalytic processes in the multiple‐site confined environment of zeolite nanopores are considered. The nature and cooperativity of the interactions between the multiple exchangeable cations and the substrates determine the reaction energetics of the elementary steps involved in the DACD process.
Specificity and biologic activities of novel anti-membrane IgM antibodies

The concept that the B-cell Receptor (BCR) initiates a driver pathway in lymphoma-leukemia has been clinically validated. Previously described unique BCR Ig-class-specific sequences (proximal domains (PDs)), are not expressed in serum Ig (sIg). As a consequence of sequence and structural differences in the membrane IgM (mIgM) μ-Constant Domain 4, additional epitopes distinguish mIgM from sIgM. mAbs generated to linear and conformational epitopes, restricted to mIgM and not reacting with sIgM, were generated despite the relative hydrophobicity of the PDm sequence. Anti-PD mAbs (mAb1, mAb2, and mAb3) internalize mIgM. Anti-mIgM mAb4, which recognizes a distinct non-ligand binding site epitope, mediates mIgM internalization, and in low-density cultures, growth inhibition, anti-clonogenic activity, and apoptosis. We show that mAb-mediated mIgM internalization generally does not interrupt BCR-directed cell growth, however, mAb4 binding to a non-ligand binding site in the mIgM PDm-μC4 domain induces both mIgM internalization and anti-tumor effects. BCR micro-clustering in many B-cell leukemia and lymphoma lines is demonstrated by SEM micrographs using these new mAb reagents. mAb4 is a clinical candidate as a mediator of inhibition of the BCR signaling pathway. As these agents do not bind to non-mIgM B-cells, nor cross-react to non-lymphatic tissues, they may spare B-cell/normal tissue destruction as mAb-drug conjugates.
Survey evidence on wage rigidity and unemployment : Sweden in the 1990s

This study reports the results from a repeat survey among managers in Swedish manufacturing, designed to explore how a severe and prolonged macroeconomic shock affects wage rigidity and unemployment. Our second survey was conducted in 1998, when the unemployment rate was much higher, and the inflation rate much lower, than when we conducted the first survey in 1991. We find no evidence that the increase in unemployment has softened the mechanisms generating wage rigidity. On the contrary, we conclude that – because of severe downward nominal wage rigidity – real wages have become more rigid during Sweden’s move to a low-inflation environment. We also report a range of new evidence on underbidding, efficiency wage mechanisms, job security legislation, workers’ wage norms, and to what extent the long-term unemployed are subject to statistical discrimination.
The future for Sundaic lowland forest birds: long-term effects of commercial logging and fragmentation

The lowland forests of the Sundaic region are disappearing at immense speed, and whatever survives of them will inevitably suffer the effects of internal degradation (from logging in particular) and of fragmentation. A review of the various studies of the impact of logging and fragmentation on the avifaunas of forested sites throughout the region consistently indicates that large areas of logged forest retain the majority of species present prior to logging, but that forest fragments— apparently even relatively large patches with a high proportion of primary forest—lose a significant number of species. Of 274 resident forest bird species confined to the lowlands of the Sundaic region (excluding Palawan), 83 (30% of the avifauna) are adversely affected by fragmentation and 26 (9.5%) negatively affected by logging, with forest-interior sallying insectivores, terrestrial insectivores and woodpeckers being particularly susceptible to both threats. In total, available data suggest that at least 91 and possibly 132+ species, or 33–50% of the lowland forest avifauna, respond negatively to the effects of these processes in some parts of their range. In the Sunda region, however, fragmentation would seem to be a much more serious threat to the survival of certain forest bird species than the selective logging of continuous forest. This conclusion suggests that the area of forest estate set aside for the production of timber is likely to have important (albeit secondary) conservation potential if (but only if) strict management regimes eliminate/ minimise fire, further clearance and penetration by settlers and hunters (and possibly only if contiguous areas of primary lowland forest are left intact).
Prevalence of Acinetobacter baumannii bacteremia in intensive care units of Ibn Rochd University Hospital, Casablanca

Background and Objectives: Acinetobacter baumannii bacteremia are grave because of the multi-resistance of the organism to antibiotics. This study aimed to determine the prevalence of A. baumannii isolated from blood cultures and to describe their antibiotic resistance patterns. Materials and Methods: A retrospective longitudinal study was conducted on blood cultures between 2010 and 2014 from all Ibn Rochd University Hospital intensive care units; it was based on the exploitation of microbiology laboratory database (duplicates were excluded). Isolation and identification of A. baumannii were performed according to standard techniques of bacteriology and susceptibility testing as recommended by the CLSI. PCR was used to detect β-Lactamase genes, blaOXA-51, blaOXA-23. Results: Among the 4232 samples received at the laboratory, 2402 (56.8%) were positive. Negative coagulase Staphylococcus was isolated in 21.6% of cases followed by A. baumannii (9.2%), and K. pneumoniae (9.1%). A. baumannii strains were resistant to most antibiotics tested: imipenem (75.7%), ceftazidim (85.4%), cefotaxim (98.6%), gentamicin (78.1%), amikacin (63.5%) and ciprofloxacin (88.2%). All A. baumannii strains, resistant to carbapenem, tested were positive for blaOXA-51 genes and 87.5% expressed the blaOXA-23 genes. Conclusion: A. baumannii was the second germ frequently isolated from blood cultures in intensive care units. It was multi-resistant to antibiotics. The strengthening of hospital hygiene measures and surveillance of antibiotic resistance is needed to limit the spread of germs and to optimize the management of antibiotics.
β-Lactam Antibiotics Targeting PBP1 Selectively Enhance Daptomycin Activity against Methicillin-Resistant Staphylococcus aureus

ABSTRACT The activity of daptomycin (DAP) against methicillin-resistant Staphylococcus aureus (MRSA) is enhanced in the presence of subinhibitory concentrations of antistaphylococcal β-lactam antibiotics by an undefined mechanism. Given the variability in the penicillin-binding protein (PBP)-binding profiles of different β-lactam antibiotics, the purpose of this study was to examine the relative enhancement of DAP activity against MRSA by different β-lactam antibiotics to determine if a specific PBP-binding profile is associated with the ability to enhance the anti-MRSA activity of DAP. We determined that both broad- and narrow-spectrum β-lactam antibiotics known to exhibit PBP1 binding demonstrated potent enhancement of DAP anti-MRSA activity, whereas β-lactam antibiotics with minimal PBP1 binding (cefoxitin, ceftriaxone, cefaclor, and cefotaxime) were less effective. We suspect that PBP1 disruption by β-lactam antibiotics affects pathways of cell division in S. aureus that may be a compensatory response to DAP membrane insertion, resulting in DAP hypersusceptibility.
Identifying Host Molecular Features Strongly Linked With Responses to Huanglongbing Disease in Citrus Leaves

A bioinformatic analysis of previously published RNA-Seq studies on Huanglongbing (HLB) response and tolerance in leaf tissues was performed. The aim was to identify genes commonly modulated between studies and genes, pathways and gene set categories strongly associated with this devastating Citrus disease. Bioinformatic analysis of expression data of four datasets present in NCBI provided 46–68 million reads with an alignment percentage of 72.95–86.76%. Only 16 HLB-regulated genes were commonly identified between the three leaf datasets. Among them were key genes encoding proteins involved in cell wall modification such as CESA8, pectinesterase, expansin8, expansin beta 3.1, and a pectate lyase. Fourteen HLB-regulated genes were in common between all four datasets. Gene set enrichment analysis showed some different gene categories affected by HLB disease. Although sucrose and starch metabolism was highly linked with disease symptoms, different genes were significantly regulated depending on leaf growth and infection stages and experimental conditions. Histone-related transcription factors were highly affected by HLB in the analyzed RNA-Seq datasets. HLB tolerance was linked with induction of proteins involved in detoxification. Protein–protein interaction (PPI) network analysis confirmed a possible role for heat shock proteins in curbing disease progression.
Original Symbol Phase Rotated Secure Transmission Against Powerful Massive MIMO Eavesdropper

Massive multiple-input multiple-output (MIMO) has been extensively studied and considered as a key enabling technology for the fifth generation (5G) wireless communication systems, due to its potential to achieve high energy efficiency and spectral efficiency. As the concept of massive MIMO becomes more popular, it is plausible that the eavesdroppers will also employ massive antennas, which may remarkably enhance their ability to intercept the information. In this paper, motivated by the need to protect against the eavesdroppers equipped with powerful large antenna arrays, which has received scarce attention in the literature, a physical layer security approach called original symbol phase rotated (OSPR) secure transmission scheme is proposed to defend against eavesdroppers armed with unlimited antennas. The basic idea of the proposed OSPR scheme is to randomly rotate the phase of original symbols at the base station (BS) before they are transmitted, so that the massive MIMO eavesdropper will be confused by the intercepted signals, which may not represent the true information symbols. However, the legitimate users are able to infer the correct phase rotations and take proper inverse operations to recover the original symbols. We show that when the BS has a large enough, but finite number of antennas, the proposed OSPR scheme can achieve a considerable security performance in that the eavesdropper is unable to recover most of the original symbols, even with unlimited antennas. The process and the security performance of the proposed OSPR scheme are presented in detail. Simulation results are provided to further corroborate that the proposed OSPR scheme is a potential green secure transmission candidate technique for the future wireless networks.
Participation of Arachidonic Acid Metabolism in the Aortic Aneurysm Formation in Patients with Marfan Syndrome

Marfan syndrome (MFS) is a pleiotropic genetic disease involving the cardiovascular system where a fibrillin-1 mutation is present. This mutation is associated with accelerated activation of transforming growth factor β (TGFβ1) which contributes to the formation of aneurysms in the root of the aorta. There is an imbalance in the synthesis of thromboxane A2 (TXA2) and prostacyclin, that is a consequence of a differential protein expression of the isoforms of cyclooxygenases (COXs), suggesting an alteration of arachidonic acid (AA) metabolism. The aim of this study was to analyze the participation of AA metabolism associated with inflammatory factors in the dilation and dissection of the aortic aneurysm in patients with MFS. A decrease in AA (p = 0.02), an increase in oleic acid (OA), TGFβ1, tumor necrosis factor alpha (TNFα), prostaglandin E2 (PGE2) (p < 0.05), and COXs activity (p = 0.002) was found. The expressions of phospholipase A2 (PLA2), cytochrome P450 (CYP450 4A), 5-lipoxygenase (5-LOX), COX2 and TXA2R (p < 0.05) showed a significant increase in the aortic aneurysm of patients with MFS compared to control subjects. COX1, 6-keto-prostaglandin 1 alpha (6-keto-PG1α) and 8-isoprostane did not show significant changes. Histological examination of the aortas showed an increase of cystic necrosis, elastic fibers and collagen in MFS. The results suggest that there are inflammatory factors coupled to genetic factors that predispose to aortic endothelial dysfunction in the aortic tissue of patients with MFS. There is a decrease in the percentage of AA, associated with an increase of PLA2, COX2/TXA2R, CYP450 4A, and 5-LOX which leads to a greater synthesis of PGE2 than of 6-keto-PGF1α, thus contributing to the formation of the aortic aneurysm. The evident loss of the homeostasis in these mechanisms confirms that there is a participation of the AA pathway in the aneurysm progression in MFS.
Bacteriophage assays for rifampicin resistance detection in Mycobacterium tuberculosis: updated meta-analysis.

OBJECTIVE To update a previously reported meta-analysis of evidence regarding the diagnostic accuracy and performance characteristics of commercial and non-commercial phage-based assays for the detection of rifampicin (RMP) resistant tuberculosis (TB). DESIGN AND OUTCOMES: We conducted a systematic review and meta-analysis of test accuracy using bivariate random effects regression and hierarchical summary receiver operating characteristics (HSROC) analysis. Tests included the commercial FASTPlaque assays, luciferase reporter phage (LRP) assays, and in-house phage amplification tests. Sensitivity and specificity for RMP resistance were the main outcomes. RESULTS By updating previous literature searches, a total of 31 studies (with 3085 specimens) were included in this meta-analysis. Evaluations of commercial phage amplification assays yielded more variable estimates of sensitivity (range 81-100%) and specificity (range 73-100%) compared to evaluations of in-house amplification assays (sensitivity range 88-100%, specificity range 84-100%). LRP evaluations yielded the most consistent estimates of diagnostic accuracy, with seven of eight studies reporting 100% sensitivity and four of eight reporting 100% specificity. Estimates of accuracy failed to capture a major failing of the commercial assay, i.e., the rate of contaminated and indeterminate results. These ranged from 3% to 36% in studies looking at direct detection of RMP resistance from patient specimens (mean 20%). CONCLUSION Phage-based assays will require further development to maximise interpretable results and reduce technical failures. Once technical issues are resolved, impact on patient-important outcomes and cost-effectiveness need to be determined to inform policy for widespread use.