Miracle-dz/UniFAR-FTUs huggingface dataset:
The Santa Claus problem

We consider the following problem: The Santa Claus has n presents that he wants to distribute among m kids. Each kid has an arbitrary value for each present. Let p<sub>ij</sub> be the value that kid i has for present j. The Santa's goal is to distribute presents in such a way that the least lucky kid is as happy as possible, i.e he tries to maximize min<sub>i=1,. ,m</sub> sum<sub>j ∈ S<sub>i</sub></sub> p<sub>ij</sub> where S<sub>i</sub> is a set of presents received by the i-th kid.Our main result is an O(log log m/log log log m) approximation algorithm for the restricted assignment case of the problem when p<sub>ij</sub> ∈ p<sub>j</sub>,0 (i.e. when present j has either value p<sub>j</sub> or 0 for each kid). Our algorithm is based on rounding a certain natural exponentially large linear programming relaxation usually referred to as the configuration LP. We also show that the configuration LP has an integrality gap of Ω(m<sup>1/2</sup>) in the general case, when p<sub>ij</sub> can be arbitrary.
Featured Article: AMPKα2 deficiency enhanced susceptibility to ventricular arrhythmias in mice by the role of β-adrenoceptor signaling

AMP-activated protein kinase-α2 is the main catalytic subunit of the heart, which is mainly located in cardiac myocytes. The effect of AMP-activated protein kinase-α2 on the cardiac electrophysiology is barely studied. From the previous study, it is possible that AMP-activated protein kinase-α2 may have some effect on the electrophysiology of the heart. To prove the hypothesis, we used the AMP-activated protein kinase-α2 knockout (AMPKα2−/−) mice to estimate the electrophysiological characteristics of AMPKα2−/− mice and try to find the mechanism between them. We used AMP-activated protein kinase-α2 gene knockout (AMPKα2−/−) mice and control wild-type mice as the experimental animals. In the experiment, we measured the monophasic action potential duration and test the inducibility to ventricular arrhythmia in isolated mice heart with and without β-adrenoceptor antagonist metoprolol. Meanwhile, plasma concentration of catecholamine was collected. We found that AMPKα2−/− significantly shortened 90% repolarization of monophasic action potential (MAP) (MAPD90) than wild-type (47.4 ± 2.6 ms vs. 55.5 ± 2.4 ms, n = 10, P < 0.05) and were more vulnerable to be induced to ventricular arrhythmias (70% (7/10) vs. 10% (1/10), P < 0.05), accompanied by the higher concentration of catecholamine (epinephrine: 1.75 ± 0.18 nmol/L vs. 0.68 ± 0.10 nmol/L n = 10, P < 0.05; norepinephrine: 9.56 ± 0.71 nmol/L vs. 2.52 ± 0.31 nmol/L n = 10, P < 0.05). The shortening of MAPD90 and increased inducibility to ventricular arrhythmias of AMPKα2−/− could almost be abolished when perfusion with β-adrenoceptor antagonist metoprolol. It indicated that the β-adrenoceptor activation resulting from catecholamine release was mainly responsible for the relating changes of electrophysiology of AMPKα2−/−. It had great clinical significance, as in patients who had problem with AMP-activated protein kinase-α2 gene, we might use β-adrenoceptor antagonists as the prevention of arrhythmias in future. Impact statement As far as we know, this is the first time the role of AMP-activated protein kinase-α2 (AMPKα2) on the cardiac electrophysiology is explored, and we found that the β-adrenoceptor activation resulting from catecholamine release was mainly responsible for the changes of electrophysiology related to the absence of AMPKα2. This has great clinical significance, as in patients who have problems with AMPKα2 gene, we may use β-adrenoceptor antagonists for the prevention of arrhythmias in future.
Diverticular Disease: Traditional and Evolving Paradigms

Diverticular disease includes diverticulosis, which are sac protrusions of the intestinal mucosa, and diverticulitis, inflammation of the diverticula. Diverticular disease is listed as one of the top 10 leading physician diagnoses for gastrointestinal disorders in outpatient clinic visits in the United States. There are several classifications of diverticular disease ranging from asymptomatic diverticulosis to diverticulitis with complications. Several theories are linked to the development of diverticula which includes the physiology of the colon itself, collagen cross-linking, and recently challenged, low-fiber intake. The differential diagnoses of lower abdominal pain in addition to diverticular disease have overlapping signs and symptoms, which can make a diagnosis challenging. Identification of the distinct signs and symptoms of each classification will assist the practitioner in making the correct diagnosis and lead to appropriate management. The findings from recent studies have changed the paradigm of diverticular disease. The purpose of this article is to discuss traditional dogma and evolving concepts in the pathophysiology, prevention, and management of diverticular disease. Practitioners must be knowledgeable about diverticular disease for improved outcomes.
Investigation of multi-walled carbon nanotube-reinforced high-density polyethylene/carbon black nanocomposites using electrical, DSC and positron lifetime spectroscopy techniques

BACKGROUND: The positive temperature coefficient (PTC) effect on material properties has attracted much attention in recent years due to the prospects of many applications like temperature sensors, thermistors, self-regulating heaters, etc. It has been suggested that incorporation of multi-walled carbon nanotubes (MWNTs) into carbon black (CB)-filled polymers could improve the electrical properties of composites due to high conductivity and network structure and significantly reduce the required CB loading. RESULTS: We observed no change in melting temperature and crystalline transition temperature on addition of MWNTs. However, the heat of fusion decreases as the amount of conducting carboxylated MWNT (c-MWNT) filler increases and the resistivity of the composite decreases. The free volume shows an increase up to 1.5 wt% of c-MWNT content and then decreases. CONCLUSION: Well-developed crystals could not be formed due to restricted chain mobility as filler content increases. This results in minimum intermolecular interactions, and thus a decreased heat of fusion. A composite with c-MWNT content of 0.5 wt% showed the highest PTC and higher resistivity at 150 °C possibly due to the formation of flocculated structures at elevated temperature. For filler content greater than 1.5 wt%, the decrease in free volume may be due to restricted chain mobility. Copyright © 2009 Society of Chemical Industry
Chapter 8 3 D Face Recognition

Face recognition using standard 2D images struggles to cope with changes in illumination and pose. 3D face recognition algorithms have been more successful in dealing with these challenges. 3D face shape data is used as an independent cue for face recognition and has also been combined with texture to facilitate multimodal face recognition. Additionally, 3D face models have been used for pose correction and calculation of the facial albedo map, which is invariant to illumination. Finally, 3D face recognition has also achieved significant success towards expression invariance by modeling non-rigid surface deformations, removing facial expressions or by using parts-based face recognition. This chapter gives an overview of 3D face recognition and details both well-established and more recent state-of-the-art 3D face recognition techniques in terms of their implementation and expected performance on benchmark datasets.
Retrovirus-mediated HO gene transfer into endothelial cells protects against oxidant-induced injury

Yang, Liming, Shuo Quan and Nader G. Abraham. Retrovirus-mediated HO gene transfer into endothelial cells protects against oxidant-induced injury. Am. J. Physiol. 277 (Lung Cell. Mol. Physiol. 21): L127–L133, 1999. —Heme oxygenase (HO)-1 is a stress protein that has been implicated in defense mechanisms against agents that may induce oxidative injury, such as endotoxins, heme, and cytokines. Overexpression of HO-1 in cells might, therefore, protect against oxidative stress produced by certain agents, specifically heme, by catalyzing its degradation to bilirubin, which by itself has antioxidant properties. We report for the first time the successful transduction of human HO-1 gene into rat lung microvessel endothelium using replication-defective retroviral vector. Cells transduced with human HO-1 gene exhibited a 2.1-fold increase in HO-1 protein level, which was associated with a 2.3-fold elevation in enzyme activity compared with that in nontransduced cells. The cGMP content in transduced endothelial cells was increased by 2.9-fold relative to that in nontransduced cells. Moreover, human HO-1 gene-transduced endothelial cells acquired substantial resistance to toxicity produced by exposure to heme and H2O2 compared with that in nontransduced cells. The protective effect of enhancement of HO-1 activity against heme and H2O2 was reversed by pretreatment with stannic mesoporphyrin, a competitive inhibitor of HO. These data demonstrate that the induction of HO-1 in response to injurious stimuli represents an important mechanism for moderating the severity of cell damage. Regulation of HO activity in this manner may have clinical applications.
Partial Lesion of the Nigrostriatal Dopamine Pathway in Rats Impairs Egocentric Learning but Not Spatial Learning or Behavioral Flexibility

Degeneration of the nigrostriatal dopaminergic system in Parkinson’s disease (PD) causes motor dysfunction and cognitive impairment, but the etiology of the cognitive deficits remains unclear. The present study investigated the behavioral effects of partial lesions of the nigrostriatal dopamine (DA) pathway. Rats received bilateral infusions of either 6-hydroxydopamine (6-OHDA) or vehicle into the dorsolateral striatum and were tested in spatial and procedural learning tasks. Compared with intact rats, DA-depleted rats were impaired when the first task they learned required egocentric responses. Intact rats that received prior training on a spatial task were impaired while learning a subsequent body-turn task, suggesting that prior spatial training may compete with egocentric learning in intact but not DA-depleted rats. Spatial discrimination, reversal learning, and switching between allocentric and egocentric strategies were similar in both groups. The results suggest that DA loss that is not associated with gross motor pathology temporarily impairs egocentric, but not allocentric, learning or subsequent behavioral flexibility.
An Estimate of Severe and Chronic Fungal Diseases in the Republic of Kazakhstan

Our work aimed to generate a preliminary estimation of severe and chronic fungal diseases in the Republic of Kazakhstan with a model proposed by LIFE (Leading International Fungal Education). Calculations were carried out on data from 2015. Published results of studies of mycoses in Kazakhstan were identified; in the absence of national data from the scientific literature, the frequency of life-threatening and serious mycoses in defined groups of patients at risk from other countries were taken into account. We also used analogous estimations of mycoses in the Russian Federation. We estimate that 300,824 patients (1.7% of the population) were affected by severe and chronic mycotic diseases. There were an estimated 15,172 cases of acute mycoses, notably tinea capitis in children (11,847), Pneumocystis pneumonia and invasive candidiasis, and 285,652 of chronic fungal diseases. The most frequent were chronic recurrent vulvovaginal candidiasis (273,258 cases) and chronic pulmonary aspergillosis (6231). There is uncertainty about the prevalence of asthma in adults; the official number is 12,478 patients, but a prevalence estimate of 1.47% from a WHO consortium yields a prevalence of ~170,000 affected. We have used the official figures to generate the prevalence of fungal asthma, but it is likely to be a significant underestimate. Conclusion: Results of investigation indicate significant prevalence of severe and chronic mycoses in the Republic of Kazakhstan.
The feeling of the story: Narrating to regulate anger and sadness

ABSTRACT Admonitions to tell one's story in order to feel better reflect the belief that narrative is an effective emotion regulation tool. The present studies evaluate the effectiveness of narrative for regulating sadness and anger, and provide quantitative comparisons of narrative with distraction, reappraisal, and reexposure. The results for sadness (n = 93) and anger (n = 89) reveal that narrative is effective at down-regulating negative emotions, particularly when narratives place events in the past tense and include positive emotions. The results suggest that if people tell the “right” kind of story about their experiences, narrative reduces emotional distress linked to those experiences.
The optical properties of human hair II. The luster of hair fibers

Part I of this paper contains the results obtained with regard to the SPECULAR REFLECTION and DIFFUSE SCATTERING of LIGHT by HUMAN HAIR FIBERS as studied by means of GONIOPHOTOMETRY. Such data provide a means of measuring the luster of hair fibers. For evaluating the LUSTER of HAIR, the method chosen employs white light polarized perpendicular to the plane of incidence and incident at 30 o with observations being made from 0 o to - 75 o through an analyzer which is aligned with the polarizer. The integral of the trace of intensity versus the angle of observation yields the specular reflection (S) and diffase scattering (D). The luster (contrast gloss) value is (S-D)/S. Numerical values extend from zero for bleached hair in very poor condition to - 0.85 for dark hair in excellent condition. Using 3 evaluations per sample, luster values have a 90 per cent confidence limit of -+2.5 per cent of the mean value.
The Effect of a Self-management Program on the Quality-of-Life of Community-dwelling Older Adults with Chronic Musculoskeletal Knee Pain: A Pilot Randomized Controlled Trial

ABSTRACT Objectives: To evaluate a 6-week self-management program on pain conducted in a mobile setting at the residences of older adult participants. Methods: In this single-blinded randomized controlled trial, 46 community-dwelling older adults with chronic knee pain were randomly assigned to the experimental (n = 19) and wait-list control groups (n = 27). The experimental group engaged in the 6-week program while the control group was only given some pamphlets on exercise and joint care. The pain level, physical functions, QOL, and self-efficacy of the participants in both groups were assessed at baseline, post-program, and at the 1-month follow-up session. Both baseline and post-program (or post-control-period assessment) data were analyzed. Results: The results showed that the participants in the experimental group had a higher level of self-efficacy, better performance in walking test, a higher level of quality-of-life, and less frequency of pain at the post-program follow-up as compared to the control group. The effect was maintained among the experimental group at post-4-week follow-up and further reduction in pain was detected. Conclusions: The program appeared to be effective at improving the pain status, self-efficacy, functional performance, and quality-of-life of older adults. However, as the sample size was small, further study is suggested to investigate the effects of the program.
Functional variants in HCN4 and CACNA1H may contribute to genetic generalized epilepsy

Genetic generalized epilepsy (GGE) encompasses seizure disorders characterized by spike‐and‐wave discharges (SWD) originating within thalamo‐cortical circuits. Hyperpolarization‐activated (HCN) and T‐type Ca2+ channels are key modulators of rhythmic activity in these brain regions. Here, we screened HCN4 and CACNA1H genes for potentially contributory variants and provide their functional analysis.
IGF-1 Receptor Modulates FoxO1-Mediated Tamoxifen Response in Breast Cancer Cells

Tamoxifen is a common adjuvant treatment for estrogen receptor (ER)α-positive patients with breast cancer; however, acquired resistance abrogates the efficacy of this therapeutic approach. We recently demonstrated that G protein–coupled estrogen receptor 1 (GPER1) mediates tamoxifen action in breast cancer cells by inducing insulin-like growth factor–binding protein-1 (IGFBP-1) to inhibit IGF-1–dependent signaling. To determine whether dysregulation of IGFBP-1 induction is associated with tamoxifen resistance, IGFBP-1 transcription was measured in tamoxifen-resistant MCF-7 cells (TamR) after tamoxifen (Tam) treatment. IGFBP-1 transcription was not stimulated in tamoxifen-treated TamR cells whereas decreased expression of FoxO1, a known modulator of IGFBP-1, was observed. Exogenous expression of FoxO1 rescued the ability of tamoxifen to induce IGFBP-1 transcription in TamR cells. As decreased IGF-1R expression is observed in tamoxifen-resistant cells, the requirement for IGF-1R expression on tamoxifen-stimulated IGFBP-1 transcription was investigated. In TamR and SK-BR-3 cells, both characterized by low IGF-1R levels, exogenous IGF-1R expression increased FoxO1 levels and IGFBP-1 expression, whereas IGF-1R knockdown in MCF-7 cells decreased tamoxifen-stimulated IGFBP-1 transcription. Interestingly, both 17β-estradiol (E2)-stimulated ERα phosphorylation and progesterone receptor (PR) expression were altered in TamR. PR is a transcription factor known to modulate FoxO1 transcription. In addition, IGF-1R knockdown decreased FoxO1 protein levels in MCF-7 cells. Furthermore, IGF-1R or FoxO1 knockdown inhibited the ability of tamoxifen to induce IGFBP-1 transcription and tamoxifen sensitivity in MCF-7 cells. These data provide a molecular mechanistic connection between IGF-1R expression and the FoxO1-mediated mechanism of tamoxifen action in breast cancer cells. Implications: Loss of IGF-1R expression is associated with decreased tamoxifen efficacy in patients with breast cancer and the development of tamoxifen resistance. This contribution identifies potential molecular mechanisms of altered tamoxifen sensitivity in breast cancer cells resulting from decreased IGF-1R expression. Mol Cancer Res; 15(4); 489–97. ©2017 AACR.
Altered Experiential, But Not Hypothetical, Delay Discounting in Schizophrenia

Delay discounting (DD) is a future-oriented decision-making process that refers to whether one is willing to forego a smaller, sooner reward for the sake of a larger, later reward. It can be assessed using hypothetical tasks, which involve choices between hypothetical rewards of varying amounts over delay periods of days to years, or experiential tasks, which involve receiving actual rewards in real time over delay periods of seconds to minutes. Initial studies in schizophrenia have only used hypothetical tasks and have been mixed in finding either elevated or normal levels of DD. One hundred thirty-one outpatients with schizophrenia and 70 healthy controls completed hypothetical and experiential DD tasks involving monetary rewards, and the schizophrenia group was retested after 4 weeks. Although both groups showed qualitatively similar hyperbolic discounting functions on both tasks, they showed a quantitative DD difference. The schizophrenia showed higher DD than controls on the experiential task but normal DD on the hypothetical task. This pattern was not attributable to a range of potential confounds, including smoking status, substance use disorder status, or neurocognition. It was also not attributable to differences in the test–retest reliability, which was good for both tasks. The schizophrenia group’s robust pattern of altered experiential but normal hypothetical task performance points to key factors that may contribute to impaired DD in this disorder. These may include increased valuation of small (but not large) monetary rewards, or a hypersensitivity to costs associated with waiting inactively for those rewards.
Effect of Tool Geometries on Thermal History of FSW of AA1100

In the present work, three-dimensional finite element (FE) transient thermal analysis of friction stir welding (FSW) was presented for different tool geometries and different process parameters. The source of heat generation was assumed to be pure friction between the tool and workpiece interface. Thermal history of FSW of 6-mm-thick AA1100 plates for different tool geometries was calculated. The estimated thermal profiles compared well with those of the experimental results, thus validating the various assumptions made in the work. It was observed that in FSW of AA1100 with SS310 tool, friction is the major contributor to heat generation. Tool geometry with concave shoulder and conical pin was found to be preferable for FSW of AA 1100. It is preferable to keep the tool pin diameter as small as possible to avoid occurrence of a wormhole defect. Tool plunging force reduced significantly with an increase in tool rotational speed; however, the increase in heat generation was marginal.
Quantitative Analysis of Optic Disc Color

Purpose To evaluate the reproducibility of ImageJ software in analyzing the color of the optic disc. Methods One hundred twelve normal participants (56 males and 56 females) were enrolled in this study. The image of the optic disc was taken using Kowa digital disc photo-graphy, and the gray scales of the nasal rim (NR), brightest cupping center (BCC) and largest inferior retinal vein (IRV) were calculated using histogram in ImageJ. Three different observers calculated the gray scales three separate times. Reproducibility was assessed using the interclass correlation coefficient (ICC). Results The mean age of the participants was 50.6 years old (range, 11 to 82 years). The mean gray scales of the nasal rim were 91.81, 94.91, and 93.24; those of the brightest cupping center were 174.84, 179.94, and 177.76; and those of the largest inferior retinal vein were 61.85, 53.48, and 56.73 for observers 1, 2, and 3, respectively. Inter-observer reproducibility for NR, BCC and IRV was considered good based upon ICC values of 0.944, 0.860, and 0.789 for observers 1, 2, and 3, respectively. Significant age-related differences between the values of the brightest cupping center were noted, and the gray scale score was decreased in the older participants (p < 0.001). Conclusions The gray scale of the brightest cupping center diminished with age. ImageJ can be a useful objective tool with high reproducibility in the analysis of optic disc color.