Miracle-dz/UniFAR-FTUs huggingface dataset:
A non-neuroleptic treatment for schizophrenia: analysis of the two-year postdischarge risk of relapse.

The efficacy of antipsychotic drug maintenance in reducing the risk of relapse among previously hospitalized schizophrenic patients has been well documented. However, data from an ongoing study comparing two cohorts of young first admission schizophrenics--one receiving neuroleptic-oriented treatment on the wards of a community mental health center (CMHC), the other an intensive interpersonal approach in a small homelike facility in the community (Soteria House)--raise questions about the routine use of neuroleptics with this population. Our questioning of this practice is based on data analyzed from these two cohorts by means of the life table, a statistical technique appropriate for longitudinal studies. Data are presented in two ways: (1) The overall effectiveness of the two independent treatment programs (Soteria, N = 32, vs. CMHC, N = 36) is compared in terms of the probabilities of not being readmitted over the 2-year postdischarge interval. (2) Analyses that look at the influence of the original treatment setting and postdischarge antipsychotic drug status on readmission rates are presented. Program comparisons reveal Soteria patients to have a consistently higher survival rate than CMHC patients throughout 2 years postdischarge. At 12 months postdischarge, the cumulative probability of remaining well (no readmissions) significantly favors the Soteria patients (p less than .05, Mantel chi2). The overall results of the Soteria program were achieved despite the fact that all CMHC patients received neuroleptics during their original inpatient stays and about 50 percent were maintained on neuroleptics up to the point of readmission or study termination, whereas only 10 percent of Soteria subjects were treated with or maintained on neuroleptics. The survival rates by postdischarge drug status and program affiliation show the Soteria no-drug group to have the highest proportion of survivors at almost every interval throughout 24 months, the CMHC drug-maintained group to have the lowest survival rate, and the CMHC unmaintained group to be surviving at a rate generally comparable to the Soteria no-drug group.
Environmental and Health Concerns Associated with the Open Dumping of Municipal Solid Waste: A Lagos, Nigeria Experience

Landfill is the simp lest and most commonly used method of disposing municipal solid waste (MSW). In Nigeria, they are better categorized as open dumps, sited for convenience and usually involve the pitching of waste in pre-existing pits . In Lagos, the most populated city in Nigeria, most of these open pits are located near residential quarters and therefore pose a threat to public health and the environ ment. The absence of containment systems at the sites allo ws the possible percolation of leachate into groundwater. In addit ion, the methane gas generated as a result of bacterial degradation of waste is not collected and poses a potential fire hazard. The sites harbour nu merous scrap tyres which not only fuel the fires but are also breeding grounds for disease transmitting vermin. Landfill fires especially those involving tyres emit dioxin which can cause reproductive impairment and cancer in hu mans at extremely low concentrations. Scavenging birds at these sites are potential carriers of diseases. This paper examines the potential environ mental and health risks posed by some unsanitary MSW landfills in Lagos, Nigeria and calls for the need to start adopting modern waste management pract ices to ensure the protection of public health and the environment.
Functional remodeling of glutamate receptors by inner retinal neurons occurs from an early stage of retinal degeneration

Retinitis pigmentosa reflects a family of diseases that result in retinal photoreceptor death and functional blindness. The natural course of retinal changes secondary to photoreceptor degeneration involves anatomical remodeling (cell process alterations and soma displacement) and neurochemical remodeling. Anatomical remodeling predominantly occurs late in the disease process and cannot explain the significant visual deficits that occur very early in the disease process. Neurochemical remodeling includes modified glutamate receptor disposition and altered responses secondary to functional activation of glutamate receptors. We investigated the neurochemical remodeling of retinal neurons in the rd/rd (rd1) mouse retina by tracking the functional activation of glutamate receptors with a cation probe, agmatine. We provide evidence that bipolar cells and amacrine cells undergo selective remodeling of glutamate receptors during the early phases of retinal degeneration. These early neurochemical changes in the rd/rd mouse retina include the expression of aberrant functional ionotropic glutamate receptors on the cone ON bipolar cells from postnatal day 15 (P15), poor functional activation of metabotropic glutamate receptors on both rod and cone ON bipolar cells throughout development/degeneration, and poor functional activation of N‐methyl‐D‐aspartate receptors on amacrine cells from P15. Our results suggest that major neurochemical remodeling occurs prior to anatomical remodeling, and likely accounts for the early visual deficits in the rd/rd mouse retina. J. Comp. Neurol. 514:473–491, 2009. © 2009 Wiley‐Liss, Inc.
Search for nearby stars among proper motion stars selected by optical-to-infrared photometry - I. Discovery of LHS 2090 at spectroscopic distance of $\mathsf{{\vec d} \sim 6}$ pc

We present the discovery of a previously unknown very nearby star - LHS 2090 at a distance of only d=6 pc. In order to find nearby (i.e. d $ 0.18 arcsec/yr) from the NLTT catalogue (Luyten \cite{luyten7980}) in optical Digitized Sky Survey data for two different epochs and in the 2MASS data base. Only proper motion stars with large $R-K_s$ colour index and with relatively bright infrared magnitudes ($K_s<10$) were selected for follow-up spectroscopy. The low-resolution spectrum of LHS 2090 and its large proper motion (0.79 arcsec/yr) classify this star as an M6.5 dwarf. The resulting spectroscopic distance estimate from comparing the infrared $JHK_s$ magnitudes of LHS 2090 with absolute magnitudes of M6.5 dwarfs is $6.0\pm1.1$ pc assuming an uncertainty in absolute magnitude of $\pm$0.4 mag.
Adaptive linear filtering using interior point optimization techniques

We propose a novel approach for the linear adaptive filtering problem using techniques from interior point optimization. The main idea is to formulate a feasibility problem at each iteration and obtain as an estimate a filter near the center of the feasible region. It is shown, under some mild conditions, that this algorithm generates a sequence of filters converging to the optimum linear filter at the rate O(1/n), where n is the number of data samples. Furthermore, we show that the algorithm can be made recursive with a per-sample complexity of O(M/sup 2.3/), where M is the filter length. The potential of the algorithm for practical applications is demonstrated via numerical simulations where the new algorithm is shown to have superior transient behavior and improved robustness to the source signal statistics when compared to the recursive least squares (RLS) method.
Separate and Simultaneous Cumulative Effects of Content and Formal Schemata on Turkish EFL Learnersâ€™Reading

Due to the absence of a commonly accepted comprehensive reading theory, many researchers have been trying to understand the reading process by analyzing it into aset of components. Two of those components widely researched in first and second language are content background knowledge (content schemata) and the prior knowledge of rhetorical structures (formal schemata). The study aimed at investigating the separate and simultaneous combined effects of the content and formal schemata on Turkish EFLstudentsâ€™reading comprehension. In order to find out the probable effects of the two schemata, four main groups of subjects, comprising a total of 115 students, were subjected to different treatments: The first group was given treatment to build up both the content and the formal schemata simultaneously, the second group was trained to build up only the formal schemata, the third group was taught to build up only the content schemata, and the last group did not receive any special treatment and assigned as the control group. These groups of subjects were compared to one another by means of some statistical tests on the basis of their scores on reading. The results showed that the content schemata is an important factor in EFL reading, but the formal schemata and the combination of the content and formal schemata did not appear to be as important.
Towards New Maps of Global Human Values, Based on World Values Survey (6) Data

This article provides a new approach to the study of global values, based on a statistical analysis of the freely available data from the World Values Survey, 6th wave of global opinion surveys, which has now been made public. In accordance with economic approaches, we contradict the mainstream of the hitherto published global value analyses in sociology (Ronald F. Inglehart) and we think that family values (Schumpeter) and religious values (Barro) can be an important positive asset for society. Too many negative phenomena, which cannot be overlooked anymore by contemporary social science are clearly to be associated with the loss of religion (irrespective of the predominant denomination in a country): the distrust in the state of law; the shadow economy; the distance from altruistic values; a growing fatigue of democracy; the lack of entrepreneurial spirit; et cetera. We provide global maps for the new 22 value factors which result from the promax factor analysis of 78 variables from 45 countries with complete data, and we also calculate performance indices for the countries and the nine main global religious denominations, answering an old query raised by Huntington, 1996. On this account, the 5775 year old religion of Judaism and also Christian Protestantism emerge as the role models for other religions how to combine religion and the traditions of the Enlightenment. Interestingly enough, also Hinduism, Buddhism, Taoism and Roman Catholicism are assigned a positive value on our combined twelve factor indicator. Religiously committed Protestants and Roman Catholics who assign a greater importance to G’d in their life rank better on our scale than do the overall global Protestant and Roman Catholic populations.
Antibodies binding the ADAM10 substrate recognition domain inhibit Eph function

Summary The ADAM10 transmembrane metalloprotease cleaves a variety of cell surface proteins that are important in disease, including ligands for receptor tyrosine kinases of the erbB and Eph families. ADAM10-mediated cleavage of ephrins, the ligands for Eph receptors, is suggested to control Eph/ephrin-mediated cell-cell adhesion and segregation, important during normal developmental processes, and implicated in tumour neo-angiogenesis and metastasis. We previously identified a substrate-binding pocket in the ADAM10 C domain that binds the EphA/ephrin-A complex thereby regulating ephrin cleavage. We have now generated monoclonal antibodies specifically recognising this region of ADAM10, which inhibit ephrin cleavage and Eph/ephrin-mediated cell function, including ephrin-induced Eph receptor internalisation, phosphorylation and Eph-mediated cell segregation. Our studies confirm the important role of ADAM10 in cell-cell interactions mediated by both A- and B-type Eph receptors, and suggest antibodies against the ADAM10 substrate-recognition pocket as promising therapeutic agents, acting by inhibiting cleavage of ephrins and potentially other ADAM10 substrates.
Seasonal and diurnal variations of carbonyl compounds and air criteria pollutants in Monterrey , Mexico

Carbonyl compounds levels (formaldehyde and acetaldehyde) were measured in an urban site located in Monterrey Mexico using an active sampling during winter and spring, 2013. A total of 39 samples were collected using DNPH-cartridges at 09:00 h, 12:00 h and 15:00 h, and then analyzed using high performance liquid chromatography with ultraviolet detector (HPLC-UV). CO, O3, NO, NO2, NOx, and SO2 were measured by automatic analyzers during the sampling period. Formaldehyde was found to be the most abundant carbonyl. Both carbonyls showed clear diurnal and seasonal patterns. Formaldehyde mean concentrations were 35.74 + 4.37, and 33.67 + 3.92 for spring and winter, respectively. Whereas, acetaldehyde mean concentrations were 25.68 + 2.18, and 28.31 +7.91 for spring and autumn, respectively. Levels of carbonyls were higher when wind blew from WSW, where heavy traffic avenues, a railway and electric power companies are located. These sources could influence the levels of carbonyls measured in this study. Key-Words: Carbonyls, ozone, criteria pollutants, air pollution, Monterrey, COVs
Rethinking the Java SOAP Stack ♦

This paper examines the current SOAP APIs in Java, and in particular the Java API for XML-based RPC, commonly known as JAX-RPC, which is effectively the standard API for SOAP on the Java platform. We claim that JAXRPC, and indeed any SOAP API that relies upon a perfect two-way mapping between XML data and native language objects is fundamentally flawed. Furthermore, we claim that the attempt JAX-RPC makes to extend the remote method invocation metaphor to SOAP services is counterproductive. We base our argument both upon experience with JAX-RPC and SOAP, and upon experience of previous distributed computing technologies. We argue that JAX-RPC is not capable of delivering on the SOAP design goals, but conclude by suggesting an alternate system,Alpine, which is free from many known flaws of existing systems, and should prove better able to deliver upon the promise of SOAP.
Evolutionary computation - toward a new philosophy of machine intelligence (3. ed.)

What do you do to start reading evolutionary computation toward a new philosophy of machine intelligence? Searching the book that you love to read first or find an interesting book that will make you want to read? Everybody has difference with their reason of reading a book. Actuary, reading habit must be from earlier. Many people may be love to read, but not a book. It's not fault. Someone will be bored to open the thick book with small words to read. In more, this is the real condition. So do happen probably with this evolutionary computation toward a new philosophy of machine intelligence.
The self as a point of contact between social psychology and motivation

Interdisciplinarity is a mixed blessing. An attempted union between two disciplines can cook up a couscous of conflicting assumptions and theories, misaligned methodological and data analytic strategies, and disconcertingly divergent validation philosophies. The chimerical offspring of this union will be amorphous, uncompelling, and unusable. Yet sometimes such a union can turn out to be a marriage made in heaven. The union of social psychology and motivation is a case in point, with the self as master of ceremonies. The self acts as a methodological point of contact between contemporary social psychological and traditional motivational approaches. The former approach is nomothetic, experimental, and laboratory-based, whereas the latter is idiographic, naturalistic, and questionnaire-based. More importantly, the self acts as a theoretical point of contact between the two approaches. The role °f the self as the facilitator of this doubly harmonious union is illustrated though a brief exposition to the self-evaluation literature.
Cav1.4 L-Type Calcium Channels Contribute to Calpain Activation in Degenerating Photoreceptors of rd1 Mice

Retinitis pigmentosa is an inherited blinding disorder characterized by progressive degeneration and loss of photoreceptors. The exact mechanism of degeneration and cell death of photoreceptors is not known, but is thought to involve disturbed Ca2+—signaling. Ca2+ can enter the photoreceptor cell via outer segment cyclic nucleotide-gated (CNG) channels or synaptic Cav1.4 L-type voltage-gated calcium channels (VGCC). Previously, we have shown that genetic ablation of the Cngb1 gene encoding the B subunit of the rod CNG channel delays the fast progressing degeneration in the rd1 mutant mouse model of retinitis pigmentosa. In this study, we crossbred rd1 mice with the Cacna1f-deficient mouse lacking the Cav1.4 α1 subunit of the L-type VGCC. Longitudinal in vivo examinations of photoreceptor layer thickness by optical coherence tomography revealed a significant, but not sustained delay of retinal degeneration in Cacna1f x rd1 double mutant mice compared to rd1 mice. This was accompanied by a reduction of TUNEL positive cells in the early phase of rod degeneration. Remarkably, Cacna1f x rd1 double mutant mice displayed a strong decrease in the activation of the Ca2+-dependent protease calpain during photoreceptor loss. Our results show that genetic deletion of the synaptic Cav1.4 L-type VGCCs impairs calpain activation and leads to a short-term preservation of photoreceptors in the rd1 mouse.
Larval digenean preferences in two sympatric snail species at differing tidal levels off the Atlantic coast of Patagonia

Abstract Larval stages of the trematodes Maritrema madrynense and Hemiuroidea fam. gen. et sp. differentially parasitized Siphonaria lessonii and S. lateralis, two sympatric pulmonate snail species on the rocky intertidal shore at Puerto Deseado, south-western Atlantic coast of Patagonia, Argentina. Snail specimens were collected at two sampling sites with contrasting physical–chemical characteristics. One site, in the upper intertidal, was exposed to sewage from fish-processing plants, greater hydrodynamic forcing and desiccation, a wider temperature range, longer exposure to ultraviolet radiation and higher abundance of birds. The second site, in the lower intertidal, was generally characterized by less stressful environmental conditions. At both sites, S. lateralis showed a markedly higher density than S. lessonii (55.13 vs. 5.87 snails/m2, respectively). Despite this, the prevalence of both digeneans was higher in S. lessonii (17.37% and 3.52% for M. madrynense and Hemiuroidea, respectively) than in S. lateralis (0.09% and 0% for M. madrynense and Hemiuroidea, respectively). This study demonstrates high parasite specificity for the host. Low densities of S. lessonii are attributed to castration of parasitized hosts and reduction of their physiological condition. The prevalence and intensity of infection of both digenean parasites were higher at the more stressful, upper intertidal site, thus suggesting that a higher abundance of birds and exposure to sewage pollution may promote the transmission of trematodes.
How to identify students for school-based depression intervention: can school record review be substituted for universal depression screening?

PROBLEM Early identification and intervention are critical for reducing the adverse effects of depression on academic and occupational performance. Cost-effective approaches are needed for identifying adolescents at high depression risk. This study evaluated the utility of school record review versus universal school-based depression screening for determining eligibility for an indicated depression intervention program implemented in the middle school setting. METHODS Algorithms derived from grades, attendance, suspensions, and basic demographic information were evaluated with regard to their ability to predict students' depression screening scores. FINDINGS The school information-based algorithms proved poor proxies for individual students' depression screening results. However, school records showed promise for identifying low, medium, and high-yield subgroups on the basis of which efficient screening targeting decisions could be made. CONCLUSIONS Study results will help to guide school nurses who coordinate indicated depression intervention programs in school settings as they evaluate options of approaches for determining which students are eligible for participation.
Can periodicity in low altitude cloud cover be induced by cosmic ray variability in the extragalactic shock model

Variation in high energy cosmic rays (HECRs) has been proposed to explain a 62 My periodicity in terrestrial fossil biodiversity. It has been suggested that the infall of our galaxy toward the Virgo cluster could generate an extragalactic shock, accelerating charged particles and exposing the earth to a flux of high energy cosmic rays (HECRs). The oscillation of the Sun perpendicular to the galactic plane could induce 62 My periodicity in the HECR flux on the Earth, with a magnitude much higher than the Galactic cosmic ray change we see in a solar cycle. This mechanism could potentially explain the observed 62 My periodicity in terrestrial biodiversity over the past 500 My. In addition to direct effects on life from secondaries, HECRs induced air showers ionize the atmosphere leading to changes in atmospheric chemistry and microphysical processes that can lead to cloud formation including low altitude cloud cover. An increase in ionization changes the global electric circuit which could enhance the formation of cloud condensation nuclei (CCN) through microphysical processes such as electroscavenging and ion mediated nucleation, leading to an increase in the cloud cover. This could increase the albedo and reduce the solar flux reaching the ground, reducing the global temperature. Using an existing model, we have calculated the enhancement in atmospheric ionization at low altitudes resulting from exposure to HECRs. We use a conservative model to estimate the change in low altitude cloud cover from this increased ionization.
Social capital and leadership development: Building stronger leadership through enhanced relational skills

Purpose – As organizations face volatile and virtual environments there is a growing need to equip emerging leaders with skills to generate, utilize and maintain social capital. This paper aims to examine five recent, large leadership studies to clarify the role that human capital or social capital capabilities play in present day and future leadership.Design/methodology/approach – Researchers review five recent large leadership studies, assessing the human capital and/or social capital orientation of identified leadership capabilities.Findings – The analysis indicates that, although there is a primary focus on human capital capabilities, social capital skills have begun to receive more attention as components of a leader's skill set.Research limitations/implications – The review focused on five published studies and does not reflect the comprehensiveness of a meta‐analysis. Hence conclusions may not apply to all situations. Further exploration and longitudinal study of the efficacy of various development.
Prevalence of HIV and malaria: a cross-sectional study on Bioko Island, Equatorial Guinea

Malaria and HIV are two of the most severe public health problems in Africa. However, epidemiological data on Bioko Island is scarce. To investigate the prevalence of malaria and HIV infections and assess association of malaria and HIV infections and possible confounding factors, we performed a cross-sectional survey of people of malaria-endemic Bioko Island, Equatorial Guinea. A cross-sectional study of 1 526 subjects was carried out to determine the prevalence of malaria and HIV infection in Malabo region hospital on Bioko Island. Questionnaires were administered and venous blood samples were drawn for malaria parasites and HIV detection. The prevalence of participants infected with malaria and HIV in this area were 13.8% and 6.6% respectively. The average prevalence of co-infection for malaria and HIV was 0.92%. HIV-infection was significantly associated with the age and gender. Malaria infections were significantly associated with the age. This study showed that the prevalence of HIV and malaria on Bioko Island was higher than expected, although the co-infection prevalence of malaria and HIV was low. The results also indicated that malaria and HIV infections lead to more public health risk to youngsters and women.