Miracle-dz/UniFAR-FTUs huggingface dataset:
Incidence and Predictors of Radial Artery Occlusion Associated Transradial Catheterization

In this study, we sought to assess the incidence and predictors of radial artery occlusion (RAO), which is a significant complication of transradial cardiac catheterization. We prospectively evaluated the results of 106 patients who underwent coronary angiography and percutaneous coronary intervention (PCI) via the transradial approach (TRA). At the 3rd h of intervention, the radial artery was checked by palpation; color doppler ultrasonography was performed at the 24th h. Fluoroscopy duration, procedure success, and complications of the radial artery were recorded. The procedure was successfully completed in all patients. RAO was detected in eight female and two male patients. In terms of RAO, there was a statistically significant difference between males and females (p=0.019). Other parameters did not show a significant correlation with RAO. Altough did not have any effect on procedural success, eight patients developed transient radial artery spasm. Gender was not associated with radial arterial spasms (p=0.19). TRA in the diagnosis and treatment of coronary artery disease has shown high procedural success and low complication rates; it addition, it presents a low economic burden. It should be used widely and be involved in the routine cardiology residency program.
Arabidopsis Fatty Acid Desaturase FAD2 Is Required for Salt Tolerance during Seed Germination and Early Seedling Growth

Fatty acid desaturases play important role in plant responses to abiotic stresses. However, their exact function in plant resistance to salt stress is unknown. In this work, we provide the evidence that FAD2, an endoplasmic reticulum localized ω-6 desaturase, is required for salt tolerance in Arabidopsis. Using vacuolar and plasma membrane vesicles prepared from the leaves of wild-type (Col-0) and the loss-of-function Arabidopsis mutant, fad2, which lacks the functional FAD2, we examined the fatty acid composition and Na+-dependent H+ movements of the isolated vesicles. We observed that, when compared to Col-0, the level of vacuolar and plasma membrane polyunsaturation was lower, and the Na+/H+ exchange activity was reduced in vacuolar and plasma membrane vesicles isolated from fad2 mutant. Consistent with the reduced Na+/H+ exchange activity, fad2 accumulated more Na+ in the cytoplasm of root cells, and was more sensitive to salt stress during seed germination and early seedling growth, as indicated by CoroNa-Green staining, net Na+ efflux and salt tolerance analyses. Our results suggest that FAD2 mediated high-level vacuolar and plasma membrane fatty acid desaturation is essential for the proper function of membrane attached Na+/H+ exchangers, and thereby to maintain a low cytosolic Na+ concentration for salt tolerance during seed germination and early seedling growth in Arabidopsis.
Gender Differences in Creativity

Research on gender differences in creativity, including creativity test scores, creative achievements, and self-reported creativity is reviewed, as are theories that have been offered to explain such differences and available evidence that supports or refutes such theories. This is a difficult arena in which to conduct research, but there is a consistent lack of gender differences both in creativity test scores and in the creative accomplishments of boys and girls (which if anything tend to favor girls). As a result, it is difficult to show how innate gender differences in creativity could possibly explain later differences in creative accomplishment. At the same time, the large difference in the creative achievement of men and women in many fields make blanket environmental explanations inadequate, and the explanations that have been proposed thus far are at best incomplete. A new theoretical framework (the APT model of creativity) is proposed to allow better understanding of what is known about gender differences in creativity.
Interleukin 12 administration induces T helper type 1 cells and accelerates autoimmune diabetes in NOD mice

T cells play a major role in the development of insulin-dependent diabetes mellitus (IDDM) in nonobese diabetic (NOD) mice. Administration of interleukin 12 (IL-12), a key cytokine which guides the development of T helper type 1 (Th1) CD4+ T cells, induces rapid onset of IDDM in NOD, but not in BALB/c mice. Histologically, IL-12 administration induces massive infiltration of lymphoid cells, mostly T cells, in the pancreatic islets of NOD mice. CD4+ pancreas-infiltrating T cells, after activation by insolubilized anti T cell receptor antibody, secrete high levels of interferon gamma and low levels of IL- 4. Therefore, IL-12 administration accelerates IDDM development in genetically susceptible NOD mice, and this correlates with increased Th1 cytokine production by islet-infiltrating cells. These results hold implications for the pathogenesis, and possibly for the therapy of IDDM and of other Th1 cell-mediated autoimmune diseases.
KungFQ: A Simple and Powerful Approach to Compress fastq Files

Nowadays storing data derived from deep sequencing experiments has become pivotal and standard compression algorithms do not exploit in a satisfying manner their structure. A number of reference-based compression algorithms have been developed but they are less adequate when approaching new species without fully sequenced genomes or nongenomic data. We developed a tool that takes advantages of fastq characteristics and encodes them in a binary format optimized in order to be further compressed with standard tools (such as gzip or lzma). The algorithm is straightforward and does not need any external reference file, it scans the fastq only once and has a constant memory requirement. Moreover, we added the possibility to perform lossy compression, losing some of the original information (IDs and/or qualities) but resulting in smaller files; it is also possible to define a quality cutoff under which corresponding base calls are converted to N. We achieve 2.82 to 7.77 compression ratios on various fastq files without losing information and 5.37 to 8.77 losing IDs, which are often not used in common analysis pipelines. In this paper, we compare the algorithm performance with known tools, usually obtaining higher compression levels.
DNA Methyltransferase Controls Stem Cell Aging by Regulating BMI1 and EZH2 through MicroRNAs

Epigenetic regulation of gene expression is well known mechanism that regulates cellular senescence of cancer cells. Here we show that inhibition of DNA methyltransferases (DNMTs) with 5-azacytidine (5-AzaC) or with specific small interfering RNA (siRNA) against DNMT1 and 3b induced the cellular senescence of human umbilical cord blood-derived multipotent stem cells (hUCB-MSCs) and increased p16INK4A and p21CIP1/WAF1 expression. DNMT inhibition changed histone marks into the active forms and decreased the methylation of CpG islands in the p16INK4A and p21CIP1/WAF1 promoter regions. Enrichment of EZH2, the key factor that methylates histone H3 lysine 9 and 27 residues, was decreased on the p16INK4A and p21CIP1/WAF1 promoter regions. We found that DNMT inhibition decreased expression levels of Polycomb-group (PcG) proteins and increased expression of microRNAs (miRNAs), which target PcG proteins. Decreased CpG island methylation and increased levels of active histone marks at genomic regions encoding miRNAs were observed after 5-AzaC treatment. Taken together, DNMTs have a critical role in regulating the cellular senescence of hUCB-MSCs through controlling not only the DNA methylation status but also active/inactive histone marks at genomic regions of PcG-targeting miRNAs and p16INK4A and p21CIP1/WAF1 promoter regions.
Effects of dietary patterns on blood pressure: subgroup analysis of the Dietary Approaches to Stop Hypertension (DASH) randomized clinical trial.

OBJECTIVE To determine the effects of dietary patterns on blood pressure in subgroups. METHODS Dietary Approaches to Stop Hypertension (DASH) was a randomized controlled feeding study conducted at 4 academic medical centers. Participants were 459 adults with untreated systolic blood pressure less than 160 mm Hg and diastolic blood pressure 80 to 95 mm Hg. For 3 weeks, participants were fed a "control" diet. They were then randomized to 8 weeks of (1) control diet; (2) a diet rich in fruits and vegetables; or (3) a combination diet rich in fruits, vegetables, and low-fat dairy foods, and reduced in saturated fat, total fat, and cholesterol (the DASH combination diet). Weight and salt intake were held constant. Change in diastolic blood pressure was the primary outcome variable, and systolic blood pressure a secondary outcome. Subgroups analyzed included race, sex, age, body mass index, years of education, income, physical activity, alcohol intake, and hypertension status. RESULTS The combination diet significantly lowered systolic blood pressure in all subgroups (P<.008), and significantly lowered diastolic blood pressure (P<.01) in all but 2 subgroups. The fruits-and-vegetables diet also reduced blood pressure in the same subgroups, but to a lesser extent. The combination diet lowered systolic blood pressure significantly more in African Americans (6.8 mm Hg) than in whites (3.0 mm Hg), and in hypertensive subjects (11.4 mm Hg) than in nonhypertensive subjects (3.4 mm Hg) (P<.05 for both interactions). CONCLUSIONS The DASH combination diet, without sodium reduction or weight loss, significantly lowered blood pressure in virtually all subgroups examined, and was particularly effective in African Americans and those with hypertension. The DASH combination diet may be an effective strategy for preventing and treating hypertension in a broad cross section of the population, including segments of the population at highest risk for blood pressure-related cardiovascular disease.
Lectures on the plane‐wave string/gauge theory duality

These lectures give an introduction to the novel duality relating type IIB string theory in a maximally supersymmetric plane‐wave background to 𝒩 = 4, d = 4, U(N) super Yang‐Mills theory in a particular large N and large R‐charge limit due to Berenstein, Maldacena and Nastase. In the first part of these lectures the duality is derived from the AdS/CFT correspondence by taking a Penrose limit of the AdS5 × S5 geometry and studying the corresponding double‐scaling limit on the gauge theory side. The resulting free plane‐wave superstring is then quantized in light‐cone gauge. On the gauge theory side of the correspondence the composite super Yang‐Mills operators dual to string excitations are identified, and it is shown how the string spectrum can be mapped to the planar scaling dimensions of these operators. In the second part of these lectures we study the correspondence at the interacting respectively non‐planar level. On the gauge theory side it is demonstrated that the large N large R‐charge limit in question preserves contributions from Feynman graphs of all genera through the emergence of a new genus counting parameter – in agreement with the string genus expansion for non‐zero gs. Effective quantum mechanical tools to compute higher genus contributions to the scaling dimensions of composite operators are developed and explicitly applied in a genus one computation. We then turn to the interacting string theory side and give an elementary introduction into light‐cone superstring field theory in a plane‐wave background and point out how the genus one prediction from gauge theory can be reproduced. Finally, we summarize the present status of the plane‐wave string/gauge theory duality.
A Sensitized Screen for Genes Promoting Invadopodia Function In Vivo: CDC-42 and Rab GDI-1 Direct Distinct Aspects of Invadopodia Formation

Invadopodia are specialized membrane protrusions composed of F-actin, actin regulators, signaling proteins, and a dynamically trafficked invadopodial membrane that drive cell invasion through basement membrane (BM) barriers in development and cancer. Due to the challenges of studying invasion in vivo, mechanisms controlling invadopodia formation in their native environments remain poorly understood. We performed a sensitized genome-wide RNAi screen and identified 13 potential regulators of invadopodia during anchor cell (AC) invasion into the vulval epithelium in C. elegans. Confirming the specificity of this screen, we identified the Rho GTPase cdc-42, which mediates invadopodia formation in many cancer cell lines. Using live-cell imaging, we show that CDC-42 localizes to the AC-BM interface and is activated by an unidentified vulval signal(s) that induces invasion. CDC-42 is required for the invasive membrane localization of WSP-1 (N-WASP), a CDC-42 effector that promotes polymerization of F-actin. Loss of CDC-42 or WSP-1 resulted in fewer invadopodia and delayed BM breaching. We also characterized a novel invadopodia regulator, gdi-1 (Rab GDP dissociation inhibitor), which mediates membrane trafficking. We show that GDI-1 functions in the AC to promote invadopodia formation. In the absence of GDI-1, the specialized invadopodial membrane was no longer trafficked normally to the invasive membrane, and instead was distributed to plasma membrane throughout the cell. Surprisingly, the pro-invasive signal(s) from the vulval cells also controls GDI-1 activity and invadopodial membrane trafficking. These studies represent the first in vivo screen for genes regulating invadopodia and demonstrate that invadopodia formation requires the integration of distinct cellular processes that are coordinated by an extracellular cue.
Sharp estimates for green potentials on non-smooth domains

Given an open, bounded, connected domain Ω ⊂ R n , let GD, GN be the solution operators for the Poisson equation for the Laplacian in Ω with homogeneous Dirichlet and Neumann boundary conditions, respectively.The aim of this note is to describe the sharp ranges of indices for which GD, GN are smoothing operators of order two, on Besov and Triebel-Lizorkin scales in arbitrary Lipschitz domains.This builds on the work of many people who have dealt with homogeneous/inhomogenous problems for the Laplacian with Dirichlet/Neumann boundary conditions in Lipschitz domains; an excellent account can be found in [23]. Earlier results emphasized homogeneous problems with boundary data exhibiting an integer amount of smoothness.Such estimates underpin the entire work here and play the role of end-point/limiting cases in our theory. The main theorems we prove extend the work of D.Jerison and C.Kenig [20], whose methods and results are largely restricted to the case p ≥ 1, and answer the open problem # 3.2. 21 on p.121 in C. Kenig’s book [23] in the most complete fashion.When specialized to Hardy spaces (viewed as a subclass of Triebel-Lizorkin scale), our results provide a solution of a (strengthened form of a) conjecture made by D. -C.Chang, S.Krantz and E.Stein regarding the regularity of the Green potentials on Hardy spaces in Lipschitz domains.Cf. p.130 of [5] where the authors write: “ For some applications it would be desirable to find minimal smoothness conditions on ∂Ω in order for our analysis of the Dirichlet and Neumann problems to remain valid. We do not know whether C 1+e boundary is sufficient in order to obtain [Hardy space] estimates for the Dirichlet problem when p is near 1. [. ]
ICP-CVD SiN Passivation for High-Power RF InAlGaN/GaN/SiC HEMT

High-frequency Metal Insulator Semiconductor High-Electron-Mobility Transistors (MIS HEMTs) were fabricated on quaternary InAlGaN/AlN/GaN heterostructures, grown by MOCVD on a 3” SiC substrate. Specific studies were performed on SiN ICP-CVD passivation layers. Improved performances were obtained with these optimized devices at 30 GHz as evidenced by CW Load Pull characterization: an output power of 6 W/mm and a power-added efficiency of 42%. A good extrinsic transconductance value higher than 450 mS/mm and a current density up to 1.55 A/mm were also measured on these transistors.
On Becoming a Better Therapist: Evidence-Based Practice One Client at a Time

How can therapists become better at doing what they love, avoid burnout, and prevent client dropout? Respected therapist, trainer, and researcher Barry Duncan asserts that getting better at this work requires therapists to dedicate themselves to two key tasks: obtaining systematic client feedback and taking charge of their own development as a therapist. This book describes his 'Partners for Change Outcome Management System' (PCOMS), which provides systematic feedback from clients, thereby enabling therapists to identify and target clients who aren't responding to traditional treatment before they drop out. Duncan examines the common factors inherent to all successful therapies and details the importance of the therapeutic alliance as the foundation of effective therapy. He encourages therapists to expand their theoretical breadth, think deeply about the lessons they learn from their clients, and integrate these lessons into their performance. Scholarly yet deeply personal, with lively case examples and unfailing good humor, Duncan's work is essential reading for anyone who seeks to rediscover purpose in their work. New to this edition are two chapters, one demonstrating PCOMS with couples, families, and youth and the other presenting how to implement PCOMS on an organizational scale. This book also integrates the author's responses to many thoughtful questions raised by trainees and readers of the last edition.
Peritumoral Brain Edema in Intracranial Meningiomas: Effects of Radiological and Histological Factors

OBJECTIVEWe examined the radiological and histological features influencing the development of peritumoral brain edema (PTBE) among patients with meningiomas. METHODSFactors causing PTBE were retrospectively analyzed for 125 patients with primary intracranial meningiomas. These factors included tumor size, tumor location, brain-tumor interface, signal intensity on T2-weighted scans, contrast enhancement, and cyst formation (as observed on magnetic resonance imaging scans), as well as tumor vascularity and blood supply (as observed in digital subtraction angiography studies). We defined the edema/tumor volume ratio as the edema index, and we used this index to evaluate PTBE. RESULTSA relationship between the tumor size and the volume of PTBE was observed. Convexity and middle fossa meningiomas demonstrated the greatest increases in mean edema indices. Meningothelial, anaplastic, microcystic, and angiomatous subtypes exhibited higher edema indices than did other types. Multivariate analysis demonstrated two significant radiological factors: cortical penetration (as defined by the disappearance of the arachnoid layer on magnetic resonance imaging scans) (relative risk, 2.067;P = 0.0148) and vascular supply from the pial-cortical arteries (as observed on angiograms) (relative risk, 2.087;P = 0.0082). CONCLUSIONTumor infiltration into adjacent brain parenchyma and a pial-cortical blood supply are critical factors for the development of PTBE among patients with meningiomas.
THE COLLISIONS OF HVCs WITH A MAGNETIZED GASEOUS GALACTIC DISK 4

We present two-dimensional MHD numerical simulations for the interaction of high-velocity clouds with both magnetic and non-magnetic Galactic thick gaseous disks. For the magnetic models, the initial magnetic field is oriented parallel to the disk, and we consider two different field topologies (with and without tension effects): parallel and perpendicular to the plane of motion of the clouds. The impinging clouds move in oblique trajectories and fall toward the central disk with different initial velocities. The B-field lines are distorted and compressed during the collision, increasing the field pressure and tension. This prevents the cloud material from penetrating into the disk, and can even transform a high-velocity inflow into an outflow, moving away from the disk. The perturbation creates a complex, turbulent, pattern of MHD waves that are able to traverse the disk of the Galaxy, and induce oscillations on both sides of the plane. Thus, the magnetic field efficiently transmits the perturbation over a large volume, but also acts like a shield that inhibits the mass exchange between the halo and the disk. For the non-magnetized cases, we also uncover some novel features: the evolution of the shocked layer generates a tail that oscillates, creating vorticity and turbulent flows along its trajectory.
Anomaly detection using Support Vector Machine classification with k-Medoids clustering

Anomaly based Intrusion Detection System, in the recent years, has become more dependent on learning methods - specially on classifications schemes. To make the classification more accurate and effective, hybrid approaches of combining with clustering techniques are often introduced. In this paper, a better combination is proposed to address problems of the previously proposed hybrid approach of combining k-Means/k-Medoids clustering technique with Naïve Bayes classification. In this new approach, the need of large samples by the previous approach is reduced by using Support Vector Machine while maintaining the high quality clustering of k-Medoids. Simulations have been carried out by using Kyoto2006+ data sets in order to evaluate performance, accuracy, detection rate and false positive rate of the classification scheme. Experiments and analyses show that the new approach is better in increasing the detection rate as well as in decreasing the false positive rate.
Using Multidisciplinary Expert Evaluations to Test and Improve Cognitive Model Interfaces

Typically, the design of cognitive models has not emphasized the role of interfaces for describing the models' behavior. Models that populate synthetic environments are particularly complex and need support in this area. Using a variety of subject-matter experts we evaluated the use of the Situation Awareness Panel (SAP) as a tool for inspecting the behavior and reasoning of Soar agents in a JSAF simulation. We gathered suggestions on how to improve future implementations of the SAP from experts in a variety of disciplines, including military pilots, cognitive psychologists, an HCI specialist, a logistic specialist, and a software designer. Because of their diversity, we found that all were able to report unique problems with the interface, and thus now suggest about twice as many experts be used for evaluations than were previously suggested and that the experts should vary in their perspective. We used their behavior and reports to develop a task analysis that can be used as a general guide for future designs of user interfaces for cognitive models in general and for the design of interfaces for models in synthetic environments in particular. We suggest this approach of having multiple types of experts review an interface as a general method for improving complex interfaces such as interfaces to cognitive models.
Dimensions and Operationalisations of IT Governance: A Literature Review and Meta-Case Study

This paper seeks to tackle the current confusion about the constituent dimensions of IT Governance (ITG) and inconsistent operationalisation approaches inhibiting advances in research and organisational ITG practice. Through a structured literature review of ranked high-quality publications augmented by a meta-case study with five underlying projects, we find nine distinct dimensions of ITG. The input-oriented dimensions Compliance Management, IT Investment Management and ITG Improvement have received little attention in earlier conceptualisations, while the more output-oriented dimensions Business/IT Alignment and Business Value Delivery have featured more often in related studies. Scope and application of ITG may depend on the organisational context and the intentional use, such as regulatory or strategic. Depending on the context, more research seems to be warranted to develop context-dependent measurement constructs of ITG that can be compared over studies. (author's abstract)