Miracle-dz/UniFAR-FTUs huggingface dataset:
c‐kit Gene mutation at exon 17 or 13 is very rare in sporadic gastrointestinal stromal tumors

Background and Aim: Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the human gut. They frequently have gain‐of‐function mutations of the c‐kit gene, which encodes a receptor, tyrosine kinase. The mutations were found at exon 11 in most cases, and either at exon 9 or at exon 13 in rare cases. Recently, we found a family with multiple GIST and a gain‐of‐function mutation at exon 17. The family was the first reported GIST case with c‐kit gene mutation at exon 17 including sporadic GIST. Although we previously reported that the c‐kit gene mutation at exon 17 was not detected in 124 sporadic GIST by single‐strand conformation polymorphism (SSCP) analysis, the mutation at exon 17 observed in the familial GIST was detectable by the use of direct sequencing but not by our SSCP method. In the present study, we examined the mutations at exon 17 and exon 13 by using direct sequencing.
MACHINERY FOR ARTIFICIAL EMOTIONS

We present a preliminary definition and theory of artificial emotion viewed as a sequential process comprising the appraisal of the agent global state, the generation of an emotion-signal, and an emotion-response. This theory distinguishes cognitive from affective appraisal on an architecture-grounded basis. Affective appraisal is performed by the affective component of the architecture; cognitive appraisal is performed by its cognitive component. A scheme for emotion classification with seven dimensions is presented. Among them, we emphasize the roles played by emotions and the way these roles are fulfilled. It is shown how emotions are generated, represented, and used in the Salt & Pepper architecture for autonomous agents (Botelho, 1997). Salt & Pepper is a specific architecture comprising an affective engine, a cognitive and behavioral engine, and an interruption manager. Most properties of the cognitive and behavioral engine rely upon a hybrid associative, schema-based long-term memory. In Salt & Pepper, emotion-signals, represented by label, object of appraisal, urgency, and valence, are generated by the affective engine through the appraisal of the agent's global state. For each emotion-signal there are several nodes stored and interconnected in long-term memory. Each of these nodes contains an emotion response that may be executed when an emotion-signal is generated. Emotion intensity relates to the activation of the node. It is shown that the Salt & Pepper architecture for autonomous agents exhibits several properties usually related to emotion: state and mood congruence, compound emotions, autonomic emotion-responses, and different emotion-responses to the same stimulus including the generation of different motives. The implementation of a concrete example is described.
Reducing test time and area overhead of an embedded memory array built-in repair analyzer with optimal repair rate

This paper presents a built-in self repair analyzer with the optimal repair rate for embedded memory arrays. The proposed method requires only a single test, even in the worst case. By performing the must-repair analysis on the fly during the test, it selectively stores fault addresses, and the final analysis to find a solution is performed on the stored fault addresses. To enumerate all possible solutions, existing techniques use depth first search using a stack and a FSM. Instead, we propose a new algorithm and its combinational circuit implementation. Since our formulation for the circuit allows us to use the parallel prefix algorithm, it can be configured in various ways to meet area and test time requirements. The total area of our infrastructure is dominated by the number of CAM entries to store the fault addresses, and it only grows quadratically with respect to the number of repair elements.
CCF-LRU: a new buffer replacement algorithm for flash memory

NAND flash memory has been widely used for storage in embedded systems and recently in enterprise computing environment, owing to its shock-resistance, nonvolatile, low energy consumption, and high I/O speed. In addition, flash memory has the characteristics of not-in-place update and asymmetric I/O costs among read, write, and erase operations, in which the cost of write/erase operations is much higher than that of read operation. Hence, the buffer replacement algorithms in flash-based systems should take the asymmetric I/O costs into account. Previous solutions to this issue, such as CFLRU and LRU-WSR, used a clean-first scheme to first evict clean pages from the buffer. Although they outperform the traditional LRU policy in performance, they do not consider the access frequency of clean page, which will consequently result in poor I/O performance. In order to solve this problem, we present a new buffering algorithm in this paper, called CCF-LRU, which enhances the previous CFLRU and LRU-WSR methods by differentiating clean pages into cold and hot ones, and evicting cold clean pages first and delaying the eviction of hot clean pages. We conduct a trace-driven experiment on a flash memory simulation environment, and use six types of synthesized traces as well as a real OLTP trace. The results show that the CCF-LRU algorithm outperforms LRU, CFLRU and LRUWSR in write count and runtime in all experiments. In particular, it provides more than 20% improvement over its competitors both in write count and runtime, when running the real OLTP trace.
Diglossia: detecting code injection attacks with precision and efficiency

Code injection attacks continue to plague applications that incorporate user input into executable programs. For example, SQL injection vulnerabilities rank fourth among all bugs reported in CVE, yet all previously proposed methods for detecting SQL injection attacks suffer from false positives and false negatives. This paper describes the design and implementation of DIGLOSSIA, a new tool that precisely and efficiently detects code injection attacks on server-side Web applications generating SQL and NoSQL queries. The main problems in detecting injected code are (1) recognizing code in the generated query, and (2) determining which parts of the query are tainted by user input. To recognize code, DIGLOSSIA relies on the precise definition due to Ray and Ligatti. To identify tainted characters, DIGLOSSIA dynamically maps all application-generated characters to shadow characters that do not occur in user input and computes shadow values for all input-dependent strings. Any original characters in a shadow value are thus exactly the taint from user input. Our key technical innovation is dual parsing. To detect injected code in a generated query, DIGLOSSIA parses the query in tandem with its shadow and checks that (1) the two parse trees are syntactically isomorphic, and (2) all code in the shadow query is in shadow characters and, therefore, originated from the application itself, as opposed to user input. We demonstrate that DIGLOSSIA accurately detects both SQL and NoSQL code injection attacks while avoiding the false positives and false negatives of prior methods. By recasting the problem of detecting injected code as a string propagation and parsing problem, we gain substantial improvements in efficiency and precision over prior work. Our approach does not require any changes to the databases, Web servers, or Web browsers, adds virtually unnoticeable performance overhead, and is deployable today.
A double-masked, randomized 1-year study comparing dorzolamide (Trusopt), timolol, and betaxolol. International Dorzolamide Study Group.

OBJECTIVE To investigate the safety profile and efficacy of 2.0% dorzolamide hydrochloride, when administered three times daily for up to 1 year, compared with that of 0.5% timolol maleate and 0.5% betaxolol hydrochloride, each administered twice daily. In addition, the effect of adding dorzolamide to the regimen of patients with inadequate ocular hypotensive efficacy while they were receiving one of the two beta-adrenoceptor antagonists and the effect of adding timolol to the regimen of patients receiving dorzolamide were also evaluated. DESIGN A double-masked, randomized, parallel comparison. SETTING Multinational study at 34 international sites. PATIENTS Five hundred twenty-three patients with open-angle glaucoma or ocular hypertension, 17 to 85 years of age. Patients currently using ocular hypotensive medications were required to undergo a washout. INTERVENTION Two percent dorzolamide three times a day, 0.5% timolol (Timoptic, Merck, Whitehouse Station, NJ) twice daily, and 0.5% betaxolol solution (Betoptic, Alcon, Fort Worth, Tex) twice daily. RESULTS At 1 year, the mean percent reduction in intraocular pressure at peak of 2% dorzolamide, 0.5% timolol, and 0.5% betaxolol was approximately 23%, 25%, and 21%, respectively. At afternoon trough, the mean percent reduction in intraocular pressure was 17%, 20%, and 15% for dorzolamide, timolol, and betaxolol, respectively. CONCLUSIONS The ocular hypotensive efficacy of 2.0% dorzolamide, given three times a day, is comparable with that of 0.5% betaxolol, given twice daily, for up to 1 year. In addition, long-term use of dorzolamide was not associated with clinically meaningful electrolyte disturbances or systemic side effects commonly observed with the use of oral carbonic anhydrase inhibitors.
Unilateral Galactorrhea Associated with Low-dose Escitalopram

Galactorrhea is a rare adverse effect of selective serotonin reuptake inhibitor treatment. We report a 27-year-old woman who developed unilateral breast engorgement with galactorrhea 18 days after initiation of escitalopram (10 mg/day). The symptom remitted 7 days after withdrawal of escitalopram and did not subsequently recur during maintenance therapy with agomelatine (25 mg/day).
Automatic repositioning of single voxels in longitudinal 1H MRS studies

An automatic procedure, allowing the prospective registration of brain MRI images and the acquisition of nearly identical brain volumes (coverage and orientation) in longitudinal exams, is presented. This procedure, based on a fast registration algorithm and a tailored pulse sequence, is used to reposition single voxels for 1H MRS data acquired in vivo. The impact of the repositioning method on the extent of voxel overlap and on the reproducibility of metabolite concentration measurements is studied. A statistically significant increase in voxel overlap and generally decreased short‐term measurement variability (decreased coefficients of variation and increased reproducibility coefficients) are observed. Differences in the long‐term variances of metabolite concentrations and concentration ratios measured using the eye and automatic repositioning scheme, however, do not reach statistical significance. The improved workflow associated with the use of the automatic repositioning process, which obviates the need for skilled operator intervention for voxel repositioning, suggests that approaches similar to the one presented here may be a standard element in tomorrow's longitudinal MRI and MRS exams. Copyright © 2005 John Wiley & Sons, Ltd.
Is plagiarism changing over time? A 10-year time-lag study with three points of measurement

ABSTRACT Are more students cheating on assessment tasks in higher education? Despite ongoing media speculation concerning increased ‘copying and pasting’ and ghostwritten assignments produced by ‘paper mills’, few studies have charted historical trends in rates and types of plagiarism. Additionally, there has been little comment from researchers as to the best way to assess changes in plagiarism over time. In this paper, we discuss the relative strengths and weaknesses of research designs for assessing changes in plagiarism over time, namely cross-sectional, longitudinal, and time-lag. We also report the results of our own time-lag study of plagiarism. We assessed self-reported engagement in, awareness of, and attitudes towards plagiarism in three comparable groups of students at the same university on three occasions, each separated by five years (2004, 2009, and 2014). The data from our study paint an encouraging picture of increased understanding and reduced occurrence of several forms of plagiarism, with no upward trend in verbatim copying or ghostwriting. We suggest that technological and educational initiatives are counteracting the potential for increased plagiarism from online sources.
Anti-Immigrant Sentiment and Majority Support for Three Types of Welfare

ABSTRACT Past research suggests that majority evaluations of welfare deservingness are structured along ethnic dividing lines. The fact that poverty and immigrant status are highly associated across Europe's increasingly ethnically diverse societies may thus lead majorities to withdraw support from welfare programs that transfer money to people who are different from themselves. Utilizing measures of general welfarism, most prior studies have not addressed the interplay between attitudes toward immigrants and support for specific welfare types that rely on different notions of entitlement and attract varying levels of take-up among natives and immigrants. Addressing this gap in the literature and focusing on the example of Germany, this paper asks to what extent anti-immigrant sentiment relates to native-born Germans’ attitudes toward the government's responsibility to care for three recipient groups: the unemployed, the old, and the sick. Anti-immigrant attitudes expressed as ethnic prejudice are associated with lowered support for government intervention to assist the unemployed, while support for old-age and sickness assistance does not appear to be related to levels of negative out-group sentiment. The results suggest that those who harbor ethnic prejudice are more likely to oppose aid that is predominantly means-tested, rather than universal or contribution-based, and that does benefit a large number of non-natives. The negative association between prejudice and support for unemployment assistance is independent of concerns with the economic viability of the welfare system in the face of immigration. This points to the relevance of negative affect beyond subjectively rational motives.
Urographic contrast media reactions and anxiety.

Four groups of patients were tested for reactions to intravenous sodium iothala-mate for urography. Intravenous diazepam, subcutaneous atropine, and oral tincture of belladonna failed to reduce reactions to the contrast medium. Hypnotic suggestion was effective in reducing reactions to a statistically significant degree in nausea and vomiting and may also be helpful in urticaria. Anxiety appears to be the most important factor in so-called idiosyncratic reactions to urographie contrast media. Radiologists should perform these examinations in such a manner as to reduce this anxiety rather than increase it.
Collective dynamics of social annotation

The enormous increase of popularity and use of the worldwide web has led in the recent years to important changes in the ways people communicate. An interesting example of this fact is provided by the now very popular social annotation systems, through which users annotate resources (such as web pages or digital photographs) with keywords known as “tags. ” Understanding the rich emergent structures resulting from the uncoordinated actions of users calls for an interdisciplinary effort. In particular concepts borrowed from statistical physics, such as random walks (RWs), and complex networks theory, can effectively contribute to the mathematical modeling of social annotation systems. Here, we show that the process of social annotation can be seen as a collective but uncoordinated exploration of an underlying semantic space, pictured as a graph, through a series of RWs. This modeling framework reproduces several aspects, thus far unexplained, of social annotation, among which are the peculiar growth of the size of the vocabulary used by the community and its complex network structure that represents an externalization of semantic structures grounded in cognition and that are typically hard to access.
Borrelia burgdorferi sensu lato and co‐infections with Anaplasma phagocytophilum and Rickettsia spp. in Ixodes ricinus in Hamburg, Germany

To obtain initial data on Borrelia burgdorferi sensu lato (Spirochaetales: Spirochaetaceae) in Ixodes ricinus (Ixodida: Ixodidae) ticks in Hamburg, Germany, 1400 questing ticks were collected by flagging at 10 different public recreation areas in 2011 and analysed using probe‐based quantitative real‐time polymerase chain reaction. The overall rate of infection with B. burgdorferi s.l. was 34.1%; 30.0% of adults were infected (36.7% of females and 26.0% of males), as were 34.5% of nymphs. Significant differences in tick infection rates were observed between the spring and summer/autumn months, as well as among sampling locations. Borrelia genospecies identification by reverse line blotting was successful in 43.6% of positive tick samples. The most frequent genospecies was Borrelia garinii/Borrelia bavariensis, followed by Borrelia afzelii, Borrelia valaisiana, B. burgdorferi sensu stricto, Borrelia spielmanii, Borrelia bissettii and Borrelia lusitaniae. Based on previously published data, co‐infection of Borrelia and Rickettsiales spp. was determined in 25.8% of ticks. Overall, 22.9% of ticks were co‐infected with Rickettsia spp. (Rickettsiales: Rickettsiaceae), 1.7% with Anaplasma phagocytophilum (Rickettsiales: Anaplasmataceae), and 1.2% with both pathogens. Study results show a high prevalence of Borrelia‐positive ticks in recreation areas in the northern German city of Hamburg and the potential health risk to humans in these areas should not be underestimated.
Capacity Analysis for OFDM Systems with Transceiver I/Q Imbalance

OFDM systems have gained utmost importance for wireless communications requiring ever higher data rates. The maximum data rate that can be achieved is, however, limited by the wireless communications channel as well as by hardware imperfections that can not be avoided in practice. One of the most serious hardware imperfections affecting the performance of OFDM systems is transceiver I/Q imbalance. This paper studies the maximum data rate, i.e. the capacity of OFDM systems that are impaired by transceiver I/Q imbalance of low-cost mobile terminals. Both, the downlink and the uplink case are considered. Closed-form expressions are derived for the ergodic system capacity and the outage probability considering different types of Rayleigh fading channels. Numerical examples are given to provide clear insight into the system capacity degradation due to transceiver I/Q imbalance.
A synthetic peptide initiates Gerstmann-Sträussler-Scheinker (GSS) disease in transgenic mice.

The molecular basis of the infectious, inherited and sporadic forms of prion diseases is best explained by a conformationally dimorphic protein that can exist in distinct normal and disease-causing isoforms. We identified a 55-residue peptide of a mutant prion protein that can be refolded into at least two distinct conformations. When inoculated intracerebrally into the appropriate transgenic mouse host, 20 of 20 mice receiving the beta-form of this peptide developed signs of central nervous system dysfunction at approximately 360 days, with neurohistologic changes that are pathognomonic of Gerstmann-Sträussler-Scheinker disease. By contrast, eight of eight mice receiving a non-beta-form of the peptide failed to develop any neuropathologic changes more than 600 days after the peptide injections. We conclude that a chemically synthesized peptide refolded into the appropriate conformation can accelerate or possibly initiate prion disease.
Dual regulation of receptor tyrosine kinase genes EGFR and c-Met by the tumor-suppressive microRNA-23b/27b cluster in bladder cancer

Recent clinical trials of chemotherapeutics for advanced bladder cancer (BC) have shown limited benefits. Therefore, new prognostic markers and more effective treatment strategies are required. One approach to achieve these goals is through the analysis of RNA networks. Our recent studies of microRNA (miRNA) expression signatures revealed that the microRNA-23b/27b (miR-23b/27b) cluster is frequently downregulated in various types of human cancers. However, the functional role of the miR-23b/27b cluster in BC cells is still unknown. Thus, the aim of the present study was to investigate the functional significance of the miR-23b/27b cluster and its regulated molecular targets, with an emphasis on its contributions to BC oncogenesis and metastasis. The expression levels of the miR-23b/27b cluster were significantly reduced in BC clinical specimens. Restoration of mature miR-23b or miR-27b miRNAs significantly inhibited cancer cell migration and invasion, suggesting that these clustered miRNAs function as tumor suppressors. Gene expression data and in silico analysis demonstrated that the genes coding for the epidermal growth factor receptor (EGFR) and hepatocyte growth factor receptor (c-Met) were potential targets of the miR-23b/27b cluster. Luciferase reporter assays and western blotting demonstrated that EGFR and c-Met receptor trypsine kinases were directly regulated by these clustered miRNAs. We conclude that the decreased expression of the tumor-suppressive miR-23b/27b cluster enhanced cancer cell proliferation, migration and invasion in BC through direct regulation of EGFR and c-Met signaling pathways. Our data on RNA networks regulated by tumor-suppressive miR-23b/27b provide new insights into the potential mechanisms of BC oncogenesis and metastasis.
Endonuclease G is required for early embryogenesis and normal apoptosis in mice

Endonuclease G (EndoG) is a nuclear-encoded mitochondrial protein reported to be important for both nuclear DNA fragmentation during apoptosis and mitochondrial DNA replication. To evaluate the in vivo function of EndoG, we have investigated the effects of EndoG deficiency in cells and mice. We found that EndoG homozygous mutant embryos die between embryonic days 2.5 and 3.5. Mitochondrial DNA copy numbers in ovulated oocytes from EndoG heterozygous mutant and wild-type mice are similar, suggesting that EndoG is involved in a cellular function unrelated to mitochondrial DNA replication. Interestingly, we found that cells from EndoG heterozygous mutant mice exhibit increased resistance to both tumor necrosis factor α- and staurosporine-induced cell death. Moreover, spontaneous cell death of spermatogonia in EndoG heterozygous mutant mice is significantly reduced compared with wild-type mice. DNA fragmentation is also reduced in EndoG+/- thymocytes and splenocytes compared with wild-type cells, as well as in EndoG+/- thymus in vivo compared with that of the wild-type mice, on activation of apoptosis. These findings indicate that EndoG is essential during early embryogenesis and plays a critical role in normal apoptosis and nuclear DNA fragmentation.