Miracle-dz/UniFAR-FTUs huggingface dataset:
Vagal Nerve Stimulation Markedly Improves Long-Term Survival After Chronic Heart Failure in Rats

Background—Diminished cardiac vagal activity and higher heart rate predict a high mortality rate of chronic heart failure (CHF) after myocardial infarction. We investigated the effects of chronic electrical stimulation of the vagus nerve on cardiac remodeling and long-term survival in an animal model of CHF after large myocardial infarction. Methods and Results—Two weeks after the ligation of the left coronary artery, surviving rats were randomized to vagal- and sham-stimulated groups. Using an implantable miniature radio-controlled electrical stimulator, we stimulated the right vagal nerve of CHF rats for 6 weeks. The intensity of electrical stimulation was adjusted for each rat, so that the heart rate was lowered by 20 to 30 beats per minute. The treated rats had significantly lower left ventricular end-diastolic pressure (17.1±5.9 versus 23.5±4.2 mm Hg, P <0.05) and higher maximum dp/dt of left ventricular pressure (4152±237 versus 2987±192 mm Hg/s, P <0.05) than the untreated rats. Improvement of cardiac pumping function was accompanied by a decrease in normalized biventricular weight (2.75±0.25 versus 3.14±0.22 g/kg, P <0.01). Although the 140-day survival of the untreated group was only half, vagal stimulation markedly improved the survival rate (86% versus 50%, P =0.008). Vagal stimulation therapy achieved a 73% reduction in a relative risk ratio of death. Conclusions—Vagal nerve stimulation markedly improved the long-term survival of CHF rats through the prevention of pumping failure and cardiac remodeling.
Estimating the Risk of Monochorionic Twins in IVF Pregnancies From the Perspective of a Prenatal Diagnosis Unit

The aim of the present work was to estimate the risk of monochorionic twin (MCT) pregnancies in in vitro fertilization (IVF) cycles using data from a prenatal diagnosis unit. This was a retrospective cross-sectional study reporting on the frequency of IVF pregnancies among women attending a prenatal diagnosis service specifically dedicated to the management of monochorionic pregnancies. The observed rate was compared with the local regional rate of IVF births (2.2%). A binomial distribution model was used to calculate the 95% CI of proportions. One hundred and forty-five monochorionic pregnancies were selected. Ten of these were achieved with IVF, corresponding to a rate of 6.9% (95% CI: 3.5–11.8), significantly higher than the background rate in the local population of 2.2%. When considering exclusively monochorionic pregnancies achieving delivery of two viable newborns (n = 132), the number of IVF pregnancies was nine (6.8%, 95% CI: 3.7–12.5). We did not detect major differences in pregnancy outcome between IVF and natural monochorionic pregnancies, with the exception of the proportion of newborns with a neonatal birth < 2,500 g (100% vs. 80%, p = .03). In conclusion, data obtained from the perspective of a prenatal diagnosis unit suggest that women undergoing IVF face a 3- to 4-fold increased risk of monochorionic pregnancies.
Infrared Thermography-Driven Flaw Detection and Evaluation of Hot Mix Asphalt Pavements

This research was conducted to study more realistic explanations of how variables are created and dealt with during hot mix asphalt (HMA) paving construction. Several paving projects across the State of Nebraska have been visited where sensory devices were used to test how the selected variables contribute to temperature differentials including density, moisture content within the asphalt, material surface temperature, internal temperature, wind speed, haul time, and equipment type. Areas of high temperature differentials are identified using an infrared camera whose usefulness was initially confirmed with a penetrating thermometer. A non-nuclear density device was also used to record how the lower temperature asphalt density compares to the more consistent hot area. After all variables were recorded, the locations were marked digitally via a handheld global positioning system (GPS) to aid in locating points of interest for future site revisits in order to verify research findings. In addition to the location-based database system using Google Earth, an extensive database query system was built which contains all data collected and analyzed during the period of this study. Research findings indicate that previously assumed variables thought to contributor to decreased density due to temperature differentials, like haul time and air temperature, have little impact on overall pavement quality. Additionally, the relationship between groups of temperature differentials and premature distresses one year after paving was clearly linked.
Neoplastic cells are a rare component in human glioblastoma microvasculature

Microvascular proliferation is a key biological and diagnostic hallmark of human glioblastoma, one of the most aggressive forms of human cancer. It has recently been suggested that stem-like glioblastoma cells have the capacity to differentiate into functional endothelial cells, and that a significant proportion of the vascular lining in tumors has a neoplastic origin. In principle, this finding could significantly impact the efficacy and development of antiangiogenic therapies targeting the vasculature. While the potential of stem-like cancer cells to form endothelium in culture seems clear, in our clinical experience using a variety of molecular markers, neoplastic cells do not contribute significantly to the endothelial-lined vasculature of primary human glioblastoma. We sought to confirm this impression by analyzing vessels in glioblastoma previously examined using chromogenic in situ hybridization (CISH) for EGFR and immunohistochemistry for mutant IDH1. Vessels containing cells expressing these definitive neoplastic markers were identified in a small fraction of tumors, but only 10% of vessel profiles examined contained such cells and when identified these cells comprised less than 10% of the vascular cellularity in the cross section. Interestingly, these rare intravascular cells showing EGFR amplification by CISH or mutant IDH1 protein by immunohistochemistry were located in the middle or outer portions of vessel walls, but not amongst the morphologic boundaries of the endothelial lining. To more directly address the capacity of glioblastoma cells to contribute to the vascular endothelium, we performed double labeling (Immunofluorescence/FISH) for the endothelial marker CD34 and EGFR gene locus. Although rare CD34 positive neoplastic cells unassociated with vessels were identified (<1%), this analysis did not identify EGFR amplified cells within vascular linings, and further supports our observations that incorporation of glioblastoma cells into the tumor vessels is at best extremely rare, and therefore of questionable clinical or therapeutic significance.
A Pilot Study of the Development of Online Learning Strategies Scale (OLSS)

This study presented a pilot development of the Online Learning Strategies Scale (OLSS) for evaluating students' online learning strategies. In-depth interviews were used for collecting candidate items of the scale. A survey based on the pool of candidate items was then administered to 136 students and a factor analysis was used to examine its construct validity. In addition, a reliability analysis was also used to assess the reliabilities of all subscales based on the extracted factors. With good validity and reliabilities, a tentative version of the OLSS was finally constructed by 22 items which were categorized in the following seven subscales: Anxiety, Attitude, Time Management, Concentration, Self-Awareness, Study Aids and Internet Literacy. This study provided valuable information for further improvement or extension of the tentative OLSS which would be a useful evaluation tool for researchers and instructors to diagnose or further understand students' abilities to learn on the Internet.
Rapid processing of urine specimens by urine screening and the AutoMicrobic system

A total of 1,500 clean-voided urine specimens were analyzed for the presence of bacteria by urine screening with the Autobac 1 system. The specimens found positive by this method were further processed on the same day for identification and for antimicrobial susceptibility testing on the AutoMicrobic system with the Enterobacteriaceae-plus Card and the General Susceptibility Card, respectively. The inocula for these tests were prepared from the centrifuged and washed growth in the eugonic broth aspirated from the Autobac cuvette chambers. Of 1,500 specimens that were analyzed, 183 contained single isolates of gram-negative bacilli. The results of these rapid procedures were compared with results for the same organisms isolated from urine specimens cultured by the conventional method. The data showed 92.3% agreement for identification and a correlation of 93.6% for antibiotic susceptibility between the two procedures. It is concluded that gram-negative bacilli can be rapidly identified and tested for antimicrobial susceptibility with a high degree of accuracy from the centrifuged eugonic broth after urine screening. These findings also suggest that the AutoMicrobic system provides a rapid and convenient method for same-day processing of positive urine cultures when combined with the urine screening procedure.
Resource discovery in distributed networks

In large distributed networks of computers, it is often the case that a subset of machines wants to cooperate to perform a task. Before they can do so, these machines need to learn of the existence of each other. In this paper we are interested in distributed algorithms whereby machines in a network learn of other machines in the network by making queries to machines they already know. The algorithms should be efficient both in terms of the time required and in terms of the total network communication required until all machines have discovered all other machines. We propose a very simple algorithm called Name-Dropper whereby all machines learn about each other within O(log’ n) rounds with high probability, where n is the number of machines in the network. The total number of connections required is O(n log2 n) and the total number of pointers which must be communicated is O(n2 log2 n), with high probability. Each of the preceding bounds is optimal to within polylogarithmic factors.
Is the Laser Diffraction Method Reliable for Soil Particle Size Distribution Analysis?

The laser diffraction method (LDM) has been increasingly applied for quantifying soil particle size distribution (PSD), owing to its advantages of rapid analysis, high reproducibility, and continuous PSD measurement for a wide range of size fractions. However, some ambiguities exist regarding the comparability of results with those obtained using other classical methods. The objective of the current study was to evaluate LDM-derived PSDs via comparisons with PSDs obtained with the standard sieve–pipette method (SPM) and from the absolute method of microscopy. A total of 277 soil samples were collected at different soil depths in a typical cropland in the northeast mountainous region of Beijing and analyzed with both SPM and LDM. Due to time and labor constraints, scanning electron microscopy (SEM) was performed on 100 samples randomly selected for the PSDs within the clay fraction withdrawn by SPM. The results manifested on the average 18.9% underestimation of clay content and 25.3% overestimation of silt content by LDM compared to SPM. These disagreements directly caused the shifts of soil texture class in 44.8% of the soil samples. Significant linear regression equations were generated to convert LDM–derived sand and silt contents to SPM–derived ones (p < 0.01). The linear conversions for the clay content were only significant for the calibration samples, but possessed negative coefficients of determination for the validation set. According to SEM, silt-sized particles were wrongly included in the clay fraction identified by SPM. Eliminating such particles, the clay contents corrected by SEM were significantly lower when assuming the shape of clay particles < 2 µm as plates or discs with constant thickness–diameter ratio of 1/10, and higher when considering the clay particles as spheres for volume calculation, in contrast to those measured by LDM (P < 0.01). Detailed volume-based PSDs within the clay fraction were further compared between SEM and LDM, revealing dissimilar PSD patterns but statistically similar median particle diameters. These findings suggest the effectiveness of LDM in soil PSD determination. Future work is needed to systematically quantify the impact of other possible factors such as clay mineralogy and refractive index on LDM-derived PSDs.
Reference ranges and diagnostic thresholds of laboratory markers of cardiac damage and dysfunction in a population of apparently healthy black Africans

Abstract Background: Due to the increasing migration flows mostly concerning Western countries, the problem of reference ranges and cut-off values is a living matter. In particular, the influence of ethnic origin on traditional and novel biochemical markers of cardiac damage, including cardiac troponin T (cTnT), ischemia modified albumin (IMA) and N-terminal prohormone brain natriuretic peptide (NT-proBNP), has not been investigated, to the best of our knowledge. Methods: CTnT, NT-proBNP and IMA were assayed by a Modular System in 34 apparently healthy black Africans originating mainly from Central Africa and in 34 apparently healthy white, non-immigrant Italians, matched for age and sex. Results: All the subjects investigated displayed cTnT values <0.01 ng/mL. Black Africans displayed significantly increased concentrations of serum IMA (107 vs. 92 kU/L, p<0.0001), but not of NT-proBNP (4.9 vs. 3.8 pmol/L, p=0.4), as compared to the white, non-immigrant Italians. Conclusions: The results of our investigation indicate that the reference ranges and the thresholds values of IMA, but not those of cTnT and NT-proBNP, may be different according to the ethnic origin of the population. Therefore, although the current decisional thresholds of both cTnT and NT-proBNP may be appropriate for diagnosing cardiac damage and dysfunction in the black African population, that of IMA may require a revision toward higher values. Clin Chem Lab Med 2008;46:714–6.
Host Fishes for Four Federally Endangered Freshwater Mussels (Unionidae) in the Apalachicola-Chattahoochee-Flint Basin

ABSTRACT We determined host use and glochidial metamorphosis success of four federally endangered mussel species from the Apalachicola-Chattahoochee-Flint River Basin. Fishes of 19–27 species in a total of 14 families were tested as potential hosts for each mussel species. Metamorphosis of Pleurobema pyriforme was observed only on six minnow species (Cyprinidae): Cyprinella venusta, Nocomis leptocephalus, Notropis amplamala, N. lutipinnis, Pimephales promelas and Semotilus atromaculatus, and metamorphosis success was >27% for all six species. Metamorphosis of Medionidus penicillatus was observed only on four darter species (Percidae): Etheostoma inscriptum, E. swaini, Percina crypta, and P. nigrofasciata, but metamorphosis success varied among species and was highest on E. inscriptum (40%) and P. nigrofasciata (39%). Metamorphosis of Hamiota subangulata was observed only on three species of black basses (Centrarchidae): Micropterus cataractae, M. coosae, and M. salmoides, and metamorphosis success was >78% on all three species. Metamorphosis of Amblema neislerii was observed on 23 species in seven families, indicating that this species is a host generalist, but metamorphosis success varied widely among species. These data augment existing host information for these species and provide a clearer picture of host breadth and the relative suitability of host species.
Epidemiology of the locomotive syndrome: The research on osteoarthritis/osteoporosis against disability study 2005–2015

Abstract Although locomotive organ disorders are major causes of disability and require support, little information is available regarding their epidemiology. Prevalence and co-existence of locomotive organ disorders including knee osteoarthritis (KOA), lumbar spondylosis (LS), hip osteoarthritis, and osteoporosis have been determined from baseline results of the Research on Osteoarthritis/Osteoporosis Against Disability (ROAD) study. KOA, LS, and hip osteoarthritis overlap in the population, while KOA and LS co-exist in 42.0% of people. Mutual associations between locomotive organ disorders, metabolic syndrome components, and mild cognitive impairment were found using baseline and 3-year follow-up data from the ROAD study. Logistic regression analysis showed that hypertension, impaired glucose tolerance, and mild cognitive impairment increase the risk of KOA. Osteoporosis at L2-4 was significantly influenced by the presence of femoral neck osteoporosis, and vice versa. In turn, excess weight was inversely associated with the occurrence of femoral neck osteoporosis. Finally, data from the 3rd survey (7-year follow-up) were used to calculate the prevalence of the locomotive syndrome using tests proposed by the Japanese Orthopaedic Association for assessing the risk of developing locomotive syndrome. Subsequently, the age-sex prevalence of stage 1 and stage 2 locomotive syndrome was estimated at 69.8% and 25.1%, respectively.
Helicobacter pylori and atrophic gastritis: importance of the cagA status.

BACKGROUND Infection with Helicobacter pylori is a major risk factor for the development of atrophic gastritis and gastric cancer. H. pylori strains can differ with respect to the presence of cagA (cytotoxin-associated gene A), a gene encoding a high-molecular-weight immunodominant antigen. H. pylori strains possessing cagA have been associated with enhanced induction of acute gastric inflammation. PURPOSE We investigated the relationship between cagA status and the development of atrophic gastritis in a cohort of subjects infected with H. pylori. METHODS Gastrointestinal endoscopy with biopsy sampling was used to study the natural history of gastritis in 58 subjects infected with H. pylori. Biopsy specimens were obtained before and after a mean follow-up period of 11.5 years (range, 10-13 years). The cagA status of each individual was determined at the follow-up visit with the use of an enzyme-linked immunosorbent assay designed to detect the presence of serum immunoglobulin G directed against the CagA protein. Two-sided Fisher's exact tests, McNemar's tests, Student's t tests, and Wilcoxon sum rank tests were used to analyze the data. RESULTS Twenty-four (41%) of the 58 evaluated subjects had serum antibodies against CagA (i.e., they were cagA positive), and 34 subjects were cagA negative. At the initial visit, moderate to severe atrophic gastritis was observed in eight (33%) of the cagA-positive subjects and in six (18%) of the cagA-negative subjects. At that time, positive cagA status and gastric atrophy were not significantly related (P = .22; Fisher's exact test; odds ratio [OR] 2.33; 95% confidence interval [CI] = 0.58-9.65). During follow-up, 16 (36%) of the 44 initially atrophy-negative subjects developed atrophic gastritis (eight [50%] of 16 cagA-positive subjects versus eight [29%] of 28 cagA-negative subjects; P = .20, Fisher's exact test; relative risk [RR] = 1.75; 95% CI = 0.82-3.76). In six of these 16 subjects (five cagA positive versus one cagA negative), atrophic gastritis was accompanied by the development of intestinal metaplasia (i.e., a change in the type of specialized cells present) (P = .02; Fisher's exact test; RR = 9.06; 95% CI = 1.16-71.0). One of the initially atrophy-negative, cagA-positive subjects developed early gastric cancer. Four (29%) of the 14 subjects initially diagnosed with atrophic gastritis showed regression of atrophy during follow-up (one cagA positive and three cagA negative). Therefore, at the end of follow-up, 15 (62%) of the 24 cagA-positive subjects had atrophic gastritis compared with 11 (32%) of the 34 cagA-negative subjects (P = .02; Fisher's exact test; OR = 3.48; 95% CI = 1.02-12.18). CONCLUSION Infection with cagA-positive H. pylori strains is associated with an increased risk for the eventual development of atrophic gastritis and intestinal metaplasia.
Adaptive single-trial error/erasure decoding of Reed-Solomon codes

Algebraic decoding algorithms are commonly applied for the decoding of Reed-Solomon codes. Their main advantages are low computational complexity and predictable decoding capabilities. Many algorithms can be extended for correction of both errors and erasures. This enables the decoder to exploit binary quantized reliability information obtained from the transmission channel: Received symbols with high reliability are forwarded to the decoding algorithm while symbols with low reliability are erased. In this paper we investigate adaptive single-trial error/erasure decoding of Reed-Solomon codes, i.e. we derive an adaptive erasing strategy which minimizes the residual codeword error probability after decoding. Our result is applicable to any error/erasure decoding algorithm as long as its decoding capabilities can be expressed by a decoder capability function. Examples are Bounded Minimum Distance decoding with the Berlekamp-Massey- or the Sugiyama algorithms and the Guruswami-Sudan list decoder.
The Satisfaction with Information about Medicines Scale (SIMS): a new measurement tool for audit and research

Objective—To develop and examine the psychometric properties of the Satisfaction with Information about Medicines Scale (SIMS), a new 17-item tool designed to assess the extent to which patients feel they have received enough information about prescribed medicines. Methods—Patients from eight diagnostic categories were recruited at hospitals in London and Brighton and completed the SIMS questionnaire during hospital admission or attendance at outpatient clinic appointments. The SIMS was evaluated in terms of its ease of use, internal consistency, test-retest reliability, and criterion related validity using existing self-report measures of adherence and patient beliefs about medicines. Results—The SIMS was well accepted by patients in a variety of clinical settings and showed satisfactory internal consistency and test-retest reliability. As predicted, higher levels of satisfaction with medicines information were associated with higher levels of reported adherence, and lower levels of satisfaction were associated with stronger concerns about the potential adverse effects of medicines, providing evidence of criterion related validity. Conclusion—The SIMS performed well on a number of psychometric indicators and shows promise as a tool for audit (measuring patients' satisfaction with information about their prescribed medicines), research (evaluating current or new forms of information provision), and clinical practice (identifying the information needs of individual patients and as an aid to planning medicine related consultations).