Miracle-dz/UniFAR-FTUs huggingface dataset:
Chromophobe renal cell carcinoma: A review of an uncommon entity

Renal cell carcinoma is the most common neoplasm of the kidney. It is a heterogeneous disease, comprised of different histological variants with a distinct clinical course, genetics and response to treatment. The various subtypes identified include clear cell, papillary and chromophobe, among others. Chromophobe renal cell carcinoma is a rare variant and accounts for 5% of all cases. These tumors are macroscopically larger when compared with other forms and are commonly diagnosed at an early stage. Despite significant advances in renal cell carcinoma therapeutics in the past decade, no standard treatment has been identified for advanced chromophobe renal cell carcinoma. Nevertheless, new molecular insights have recently become available. A familial form of renal cell carcinoma, the Birt–Hogg–Dubé syndrome, has been described and the knowledge obtained has opened research opportunities in the therapeutic arena of chromophobe renal cell carcinoma. The following manuscript will endeavor to provide an overview of this uncommon entity including pathology, epidemiology, genetics, clinical aspects, and current and future treatment options.
Training Effects of the FIFA 11+ and Harmoknee on Several Neuromuscular Parameters of Physical Performance Measures

Abstract The main purpose of this study was to analyse the training effects of the FIFA 11+ and Harmoknee on several parameters of physical performance measures in youth amateur football players. 41 adolescent players were randomised within each team into 2 groups (team 1: control vs. FIFA 11+; team 2: control vs. Harmoknee). The FIFA 11+ and Harmoknee groups performed the program 3 times a week for 4 weeks; the control groups completed their usual warm-up routines. 13 physical performance measures (joint range of motion, dynamic postural control, single legged hop limb symmetry, sprint time, jumping height and agility) were assessed. All physical performance parameters were compared via a magnitude-based inference analysis. Significant between-group differences (in favour of the FIFA 11+ players) were found for dynamic postural control (anterior [2.5%] and posteromedial [7.2%] distances), single legged hop limb symmetry (side-to-side symmetry during a triple hop test [8.3%]), 10 (8.4%) and 20 (1.8%) m sprint times and jumping height (9.1%) neuromuscular outcomes. For the Harmoknee, significant differences (in comparison to its paired control group) were found only for 10 (2.7%) and 20 (2.9%) m sprint times and jumping height (9.7%). Therefore, the main findings of this study suggest exchanging traditional warm-up programmes for the FIFA 11+ in male youth soccer players based on its superior effects on some neuromuscular parameters (sprinting, jumping and stability) of physical performance.
Prevention of Insulin-Induced Hypoglycemia in Type 1 Diabetes with Predictive Low Glucose Management System.

BACKGROUND Sensor-augmented pump therapy (SAPT) with algorithms to predict impending low blood glucose and suspend insulin delivery has the potential to reduce hypoglycemia exposure. The aim of this study was to determine whether predictive low glucose management (PLGM) system is effective in preventing insulin-induced hypoglycemia in controlled experiments. METHODS Two protocols were used to induce hypoglycemia in an in-clinic environment. (A) Insulin bolus: Insulin was administered as a manual bolus through the pump. (B) Increased basal insulin: Hypoglycemia was induced by increasing basal rates overnight to 180%. For both protocols, participants were randomized and studied on 2 separate days; a control day with SAPT alone and an intervention day with SAPT and PLGM activated. The predictive algorithm was programmed to suspend basal insulin infusion when sensor glucose was predicted to be <80 mg/dL in 30 min. The primary outcome was the requirement for hypoglycemia treatment (symptomatic hypoglycemia or plasma glucose <50 mg/dL) and was compared in both control and intervention arms. RESULTS With insulin bolus, 24/28 participants required hypoglycemia treatment with SAPT alone compared to 5/28 participants when PLGM was activated (P ≤ 0.001). With increased basal rates, all the eight SAPT-alone participants required treatment for hypoglycemia compared to only one with SAPT and PLGM. There was no post pump-suspend hyperglycemia with insulin bolus (P = 0.4) or increased basal rates (P = 0.69) in participants with 2-h pump suspension on intervention days. CONCLUSIONS SAPT with PLGM reduced the requirement for hypoglycemia treatment following insulin-induced hypoglycemia in an in-clinic setting.
The time course of attentional bias for emotional faces in anxious children

The present study investigated the time course of attentional bias for angry and happy faces in 50 primary school children (9 to 12 years). That is, the study examined the degree to which an anxiety-related attentional bias was moderated by the duration of threat exposure. Using a visual-probe task, children were shown angry and happy faces paired with neutral ones over two exposure durations: 500 and 1250 ms. Results revealed that higher levels of anxiety were associated with an attentional bias towards angry faces across the 500 ms and 1250 ms exposure durations. There were no effects of children's anxiety or stimulus exposure duration on attentional bias for happy faces. Results are discussed in relation to threat-monitoring versus vigilance-avoidance patterns of attentional bias, and developmental considerations, including comparison with findings from studies of anxiety-related attentional biases in adults.
Transformation of Vestibular Signals for the Control of Standing in Humans

During standing balance, vestibular signals encode head movement and are transformed into coordinates that are relevant to maintaining upright posture of the whole body. This transformation must account for head-on-body orientation as well as the muscle actions generating the postural response. Here, we investigate whether this transformation is dependent upon a muscle's ability to stabilize the body along the direction of a vestibular disturbance. Subjects were braced on top of a robotic balance system that simulated the mechanics of standing while being exposed to an electrical vestibular stimulus that evoked a craniocentric vestibular error of head roll. The balance system was limited to move in a single plane while the vestibular error direction was manipulated by having subjects rotate their head in yaw. Vestibular-evoked muscle responses were greatest when the vestibular error was aligned with the balance direction and decreased to zero as the two directions became orthogonal. This demonstrates that muscles respond only to the component of the error that is aligned with the balance direction and thus relevant to the balance task, not to the cumulative afferent activity, as expected for vestibulospinal reflex loops. When we reversed the relationship between balancing motor commands and associated vestibular sensory feedback, the direction of vestibular-evoked ankle compensatory responses was also reversed. This implies that the nervous system quickly reassociates new relationships between vestibular sensory signals and motor commands related to maintaining balance. These results indicate that vestibular-evoked muscle activity is a highly flexible balance response organized to compensate for vestibular disturbances. SIGNIFICANCE STATEMENT The postural corrections critical to standing balance and navigation rely on transformation of sensory information into reference frames that are relevant for the required motor actions. Here, we demonstrate that the nervous system transforms vestibular sensory signals of head motion according to a muscle's ability to stabilize the body along the direction of a vestibular-evoked disturbance. By manipulating the direction of the imposed vestibular signal relative to a muscle's action, we show that the vestibular contribution to muscle activity is a highly flexible and organized balance response. This study provides insight into the neural integration and central processing associated with transformed vestibulomotor relationships that are essential to standing upright.
Capacity and Error Probability Analysis for Orthogonal Space-Time Block Codes over Correlated Rayleigh and Rician Fading Channels

In this paper, the capacity and error probability of orthogonal space-time block codes (STBCs) are presented for PAM/PSK/QAM modulation in correlated flat fading channels. We consider an equivalent scalar AWGN (additive white Gaussian noise) channel with a channel gain proportional to the Frobenius norm of the matrix channel. A unified approach to the error probability analysis for correlated Rayleigh and Rician fading channels is presented. Closed form error probability expressions are derived for Rayleigh fading channels. We also determine the capacity and probability of error for a multiuser direct sequence code division multiple access (DS-CDMA) system employing a STBC over correlated fading channels.
Analysis of the characteristics of Federated Carpfishing Anglers in Spain

The objective of this work is to know the characteristics of the federated sport anglers who practice the method of fishing known as Carpfishing. The sample is composed of 47 anglers, (n=47) of different fishing clubs that practice the method of Carpfishing in Spain. The investigation was carried out with a quantitative design that was both transversal and descriptive. A descriptive analysis was done in which values of frequency and percentage were found. In the second place, the ANOVA test was performed to compare the differences between groups. The results demonstrate that significant differences were found in distinct items in accordance to the grouping variables analyzed. Among the conclusions, it is pointed out that in relation to the psychophysical characteristics related to the sport that the anglers try to spend as little time as possible without sleeping during a competition.
Transformational Leadership and the Implementation of Large-Scale Innovation Programs.

Examines the nature of transformational leadership and its relation to teachers’ changed practices within the context of Dutch large‐scale innovation. Presents two qualitative studies and a survey. The qualitative studies produced three dimensions of transformational leadership: vision, individual consideration, and intellectual stimulation. Within the framework of the survey, these dimensions were further operationalized and exploratively related to teachers’ concerns, teachers’ learning activities, and teachers’ changed practices. The results indicate the significance of the dimensions of transformational leadership in relation to changed teacher practices. The results also suggest the significance of intervening constructs for future research into the impact of leadership on changed teacher practices.
Personality in Perspective: Judgmental Consistency across Orientations of the Face

Though the psychological literature is replete with information about the perception of faces presented at a full-frontal view, we know very little about how faces are perceived–and impressions formed–when viewed from other angles. We tested impressions of faces at full-frontal, three-quarter, and profile views. Judgments of personality (aggressiveness, competence, dominance, likeability, and trustworthiness) and physiognomy (attractiveness and facial maturity) were significantly correlated across full-frontal, three-quarter, and profile views of male faces. When under time pressure, with only a 50 ms exposure to each face, the correlations for profile with full-frontal and three-quarter view judgments of personality (but not physiognomy) dropped considerably. However, judgments of the full-frontal and three-quarter faces were significantly correlated across the self-paced and 50 ms viewing durations. These findings therefore show that perceptions of full faces lead to relatively similar interferences across both viewing angle and time.
Elicitation of Requirements from User Documentation

This paper describes an approach for elicitation of requirements based on existing user documentation. The approach we describe in this paper supports capturing of the information found in user documentation of legacy systems, e.g., user manuals, and the specification of this information in requirements specifications, using, e.g., Use Cases. We propose a conceptual model describing the transition from user documentation to requirements artifacts describing common and variable elements of a product line model or requirements specification. We present heuristics that allow an easy identification of text elements in user documents that are then used to create a significant part of the requirements specification and product line model, respectively.
The role of the body in Kalahari San healing dances

Despite extensive interest of both scholars and the wider public in the Kalahari San healing dance, there has been little analysis of the dance that begins with the biological human body. In this paper I explore the role of the body in the dance by drawing on my own KhoeSan healing experience, professional knowledge as an osteopath and acupuncturist, wider anthropological work on possession dance and a tentative neurophysiological interpretation. My starting point is Bradford Keeney’s identification of shaking as a critical mechanism for ‘opening the body up to spirit’ (Keeney 2008). By contextualising San shaking in osteopathic and neurophysiological terms I develop the idea that San healers are applying the same sensory disposition that serves them so well as hunters and gatherers to their shamanic healing strategies. Using habits of ‘body listening’ San healers apply sophisticated techniques of manipulating the body and mind towards defined goals including the ability to heal, experience of extreme emp.
Determinants of suicidal ideation: the role of substance use disorders.

BACKGROUND This study tested the hypothesis that the amount of psychoactive substance consumed (frequency and/or quantity), life problems resulting from this use, and a DSM-IV diagnosis of substance abuse/dependence are independent risk factors associated with increased suicidal ideation in a population of psychiatric inpatients with major depressive disorder. METHOD 891 hospitalized patients with a primary diagnosis of nonpsychotic major depressive disorder (MDD) received a standardized, psychiatrist-administered assessment battery. To examine the relationship between admission suicidality and demographic, psychiatric history, and admission variables, chi-square analyses were used for categorical data and one-way ANOVAs were used for continuous indices. Stepwise hierarchical multiple regression analyses were performed to determine the set of variables that was independently related to admission suicidality level. RESULTS There was general agreement between our findings and previous literature in regard to the association between severity of Axis I diagnosis, depressed mood, hopelessness, male gender, unemployment, involuntary treatment, and alcohol/drug problems and higher suicidal ideation. In our sample of hospitalized patients with unipolar major depressive disorder, higher current drug and/or alcohol dependency and high current use of alcohol or other substances of abuse were independently associated with higher levels of suicidal ideation. CONCLUSION This association with higher suicidal ideation lends support to the importance of treating patients for both alcohol/drug problems and depression in an effort to decrease their risk for future suicide. We hope that our findings will improve the care that patients with dual diagnoses receive.
Comparative Education: Contemporary Issues and Trends.

Part 1 Introduction: trends and issues in comparative education, W.D. Halls. Part 2 Country studies: Western Europe, B.Holmes North America, R.F. Lawson Latin America, A.Oliveros Africa, A.Babs Fafunwa Arabia, K.Benhamida Australia and New Zealand, R.Burns China, India, Japan and Korea, T.Kobuyashi the socialist countries, H.G. Hofman and Z.A. Malkova. Part 3 The infrastructures of comparative education, R.Cowen.
The wireless control network: Monitoring for malicious behavior

We consider the problem of stabilizing a plant with a network of resource constrained wireless nodes. In a companion paper, we developed a protocol where each node repeatedly transmits an appropriate (stabilizing) linear combination of the values in its neighborhood. In this paper, we design an Intrusion Detection System (IDS) for this control scheme, which observes the transmissions of certain nodes and uses that information to (a) recover the plant outputs (for data-logging and diagnostic purposes) and (b) identify malicious behavior by any of the wireless nodes in the network. We show that if the connectivity of the network is sufficiently high, the IDS only needs to observe a subset of the nodes in the network in order to achieve this objective. Our approach provides a characterization of the set of nodes that should be observed, a systematic procedure for the IDS to use to identify the malicious nodes and recover the outputs of the plant, and an upper bound on the delay required to obtain the necessary information.
Young Foreign Language Learners’ Interactions During Task-Based Paired Assessments

Despite the popularity of task-based language teaching (TBLT) in foreign language (FL) education at elementary school, it remains unclear how young learners’ FL abilities can best be evaluated with tasks. The present study seeks to understand developmental differences in interactions among elementary-school students during task-based language assessment (TBLA) and aims to address the possibilities and limitations of introducing paired-TBLA among young FL learners. The participants were 32 fourth-grade students (ages 9–10) and 32 sixth-grade students (ages 11–12) and their teachers from a FL program where TBLT was mandated. The students were engaged in two sets of assessment tasks with their peers. It was found that the interaction patterns were different between the two grade levels. Compared with the sixth-grade dyads, the fourth-grade dyads showed less mutual topic development, used formulaic turn-taking more frequently, and had a harder time taking their partners’ perspectives during the tasks. Consequently, a smaller variety of interactional functions were observed among the fourth graders. The potential for eliciting a wide range of interactional functions, which is a primary advantage of introducing paired assessment, may have limited application for younger dyads. The study also discusses the strategic roles that such interactional characteristics may play among younger learners.
Strategizing as Lived Experience and Strategists' Everyday Efforts to Shape Strategic Direction

This paper draws together the ethnographic and ethnomethodological/conversation analytic traditions to outline an innovative and multidisciplinary approach for researching strategists-at-work. Ethnography is premised upon close-up observation of naturally occuring routines over time/space dimensions and ethnomethodology/conversation analysis, upon a study of people's practices and inherent tacit 'methods' for doing social and political life, much of which is accomplished through talk. Through the observation and recording of strategists talk-based interactive routines and from drawing upon seminal studies within the social sciences, the paper aims to map out a number of analytical routes for a fine-grained analysis of strategists' linguistic skills and forms of knowledge for strategizing. This includes their speaking of morals and the assembly of emotion as they construct a shared definition of the future. To illustrate the approach and its scope, the paper draws upon one ethnomethodologically informed ethnography. It will specifically focus upon aspects of the relational-rhetorical basis of strategic effectiveness as constituted by one strategist who was judged, from amongst a group of six, to have influenced strategic processes.
A practical technique for differentiation of subepidermal bullous diseases: localization of in vivo-bound IgG by laser scanning confocal microscopy.

OBJECTIVE To develop a practical technique to distinguish autoimmune subepidermal bullous diseases. DESIGN A prospective study. SETTING Academic referral center-the Department of Dermatology, Medical University of Warsaw. Patients Forty-two patients fulfilling clinical, immunological, and/or immunoelectron microscopic criteria for bullous pemphigoid (n = 31), mucous membrane pemphigoid (n = 6), or epidermolysis bullosa acquisita (n = 5), diagnosed as having disease and treated from January 1, 1997, to December 31, 2002. MAIN OUTCOME MEASURES We applied laser scanning confocal microscopy to determine the localization of in vivo-bound IgG at the basement membrane zone in biopsy specimens taken from patients' skin to compare the localization of basement membrane zone markers: antibody against beta4 integrin, antibody against laminin 5, and antibody against type IV collagen. In vivo-bound IgG was visualized by labeling with fluorescein isothiocyanate-conjugated anti-human IgG antibody, whereas basement membrane zone markers were labeled with anti-mouse Cy5-conjugated antibodies. RESULTS In patients with bullous pemphigoid, in vivo-bound IgG was localized on the epidermal side of laminin 5 and co-localized with beta4 integrin. In patients with mucous membrane pemphigoid, IgG was in vivo bound to the dermal-epidermal junction between localization of laminin 5 and type IV collagen. In patients with epidermolysis bullosa acquisita, in vivo-bound IgG was present on the dermal side of type IV collagen. CONCLUSIONS Laser scanning confocal microscopy allows precise localization of in vivo-bound IgG in patients' skin and, thus, it is a rapid method for the differentiation of mucous membrane pemphigoid from bullous pemphigoid and epidermolysis bullosa acquisita. This tool is suitable for the routine diagnosis of individual patients and for retrospective studies. This method is of special value in those patients in whom circulating autoantibodies are not detectable.
A Case of Cardiac Metastasis from Uterine Cervical Carcinoma

Cases of cardiac metastasis from uterine cervical carcinoma are rare. While they are occasionally found on autopsy, antemortem recognition is extremely rare. We confirmed a case of cardiac metastasis from cervical carcinoma antemortem, because we observed a decrease in platelet count during the course of treatment. The patient was a 27-year-old woman diagnosed with stage Ib1 uterine cervical carcinoma. Radical hysterectomy with pelvic lymphadenectomy was performed. Para-aortic lymph node metastasis was detected on positron emission tomography/computed tomography (PET-CT). Adjuvant chemotherapy was started, and most of the metastatic lesions disappeared. Pelvic lymph node recurrence was suspected on PET-CT during continued chemotherapy; therefore, treatment was shifted to radiation therapy. Tumor shrinkage was recognized, and the initial therapy was completed. A noticeable decrease in platelet count was recognized seven months after treatment. Multidetector CT was performed, and an intracardiac tumor was detected. The patient did not desire any further treatment. She died three weeks after the intracardiac tumor was confirmed. Few previous autopsy studies have reported cardiac metastasis from cervical carcinoma. Thus, it is necessary to consider the possibility of cardiac metastasis for patients diagnosed with terminal cervical carcinoma.