Miracle-dz/UniFAR-FTUs huggingface dataset:
The influence of CYP2C8*3 on carbamazepine serum concentration in epileptic pediatric patients

Abstract The aim of the present study was to investigate the distribution of CYP2C8 variants *3 and *5, as well as their effect on carbamazepine pharmacokinetic properties, in 40 epileptic pediatric patients on carbamazepine treatment. Genotyping was conducted using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), and allele-specific (AS)-PCR methods, and steady-state carbamazepine plasma concentrations were determined by high performance liquid chromatography (HPLC). The CYP2C8 *3 and *5 polymorphisms were found at frequencies of 17.5 and 0.0%, respectively. After dose adjustment, there was a difference in daily dose in CYP2C8*3 carriers compared to non carriers [mean ± standard deviation (SD): 14.19 ± 5.39 vs. 15.46 ± 4.35 mg/kg; p = 0.5]. Dose-normalized serum concentration of carbamazepine was higher in CYP2C8*3 (mean ± SD: 0.54 ± 0.18 vs. 0.43 ± 0.11 mg/mL, p = 0.04), and the observed correlation between weight-adjusted carbamazepine dose and carbamazepine concentration after dose adjustment was significant only in CYP2C8*3 non carriers (r = 0.52, p = 0.002). However, the population pharmacokinetic analysis failed to demonstrate any significant effect of CYP2C8 *3 polymorphism on carbamazepine clearance [CL L/h = 0.215 + 0.0696*SEX+ 0.000183*DD]. The results indicated that the CYP2C8*3 polymorphism might not be of clinical importance for epilepsy treatment in pediatric populations.
Relationship of increased serum brain natriuretic peptide levels with hepatic failure, portal hypertension and treatment in patients with cirrhosis.

BACKGROUND/AIMS Brain natriuretic peptide is a cardiac neurohormone secreted from ventricles in response to end diastolic pressure and increased volume. It has diuretic, natriuretic and vasodilator effects. In cirrhosis, a hyperdynamic circulation occurs because of hemodynamic and hemostatic alterations. The increase in brain natriuretic peptide concentration shows parallelism with the stage of cirrhosis. The aim of this study is to investigate the relation of increased brain natriuretic peptide level with the pathophysiologic components of cirrhosis and treatment. METHODS Ninety-five cirrhotic patients in different stages (Child-A: 33; Child-B: 25; Child-C:37) and age and sex matched 86 healthy individuals were recruited for the study. Brain natriuretic peptide concentration was measured with brain natriuretic peptide-Triage test device using fluoresan immune assay method. RESULTS Brain natriuretic peptide levels of patients with hepatic cirrhosis were significantly higher compared to control group (288.5±329.2/60.2±29.5/p=0.000, respectively). Serum brain natriuretic peptide levels were positively correlated with Child score (Child A-B-C; 201.2±266/258.7±233.6/386.5±407.7, respectively). A negative correlation was observed between brain natriuretic peptide and albumin levels (p=0.002). Brain natriuretic peptide concentration was significantly correlated with the grade of esophagus varices, and presence of ascites and collateral circulation (p=0.006; p=0.001; p=0.002; respectively). Patients receiving with beta-blocker and diuretic treatments had significantly higher brain natriuretic peptide levels. CONCLUSIONS High brain natriuretic peptide levels in patients with cirrhosis may be due to hepatocellular insufficiency or portal hypertension, but a cardiomyopathy developing insiduously should not be regarded.
Field induced quantum confinement in Indirect Semiconductors: Quantum mechanical and modified semiclassical model

Going beyond the existing semiclassical approach to calculate band-to-band tunneling (BTBT) current we have developed a quantum mechanical model incorporating confinement effects and multiple electron and hole valleys to calculate the tunnel current in a tunnel field-effect transistor. Comparison with existing semiclassical models reveals a big shift in the onset of tunneling due to energy quantization. We show that the big shift due to quantum confinement is slightly reduced by taking penetration into the gate dielectric into account. We further propose a modified semiclassical model capable of accounting for quantum confinement.
Improving Case Plans and Interventions for Adolescents on Probation: The Implementation of the SAVRY and a Structured Case Planning Form

Even when probation officers use risk assessment tools, many of their clients’ needs remain unaddressed. As such, we examined whether the implementation of the Structured Assessment of Violence Risk in Youth (SAVRY) and a structured case planning form resulted in better case plans as compared with prior practices (i.e., a nonvalidated local tool and an unstructured plan). Our sample comprised 216 adolescents on probation who were matched via propensity scores. Adolescents in the SAVRY/Structured Plan condition had significantly better case plans than those in the preimplementation condition. Specifically, following implementation, adolescents’ high need domains were more likely to be targeted in plans. Plans also scored higher on other quality indicators (e.g., level of detail). These improvements appeared to be due primarily to the structured plan rather than the SAVRY. Overall, our findings highlight that, just as structure can improve risk assessments, so too might structure improve case plans.
Defaultable Debt, Interest Rates, and the Current Account

World capital markets have experienced large scale sovereign defaults on a number of occasions, the most recent being Argentina's default in 2002. In this paper we develop a quantitative model of debt and default in a small open economy. We use this model to match four empirical regularities regarding emerging markets: defaults occur in equilibrium, interest rates are countercyclical, net exports are countercyclical, and interest rates and the current account are positively correlated. That is, emerging markets on average borrow more in good times and at lower interest rates as compared to slumps. Our ability to match these facts within the framework of an otherwise standard business cycle model with endogenous default relies on the importance of a stochastic trend in emerging markets.
Some aspects of the sequential design of experiments

Until recently, statistical theory has been restricted to the design and analysis of sampling experiments in which the size and composition of the samples are completely determined before the experimentation begins. The reasons for this are partly historical, dating back to the time when the statistician was consulted, if at all, only after the experiment was over, and partly intrinsic in the mathematical difficulty of working with anything but a fixed number of independent random variables. A major advance now appears to be in the making with the creation of a theory of the sequential design of experiments, in which the size and composition of the samples are not fixed in advance but are functions of the observations themselves.
Complementary or contradictory? The effects of structural holes and status on innovation

Abstract This study focuses on the joint effects of the firms’ access to structural holes within social networks and their status within social hierarchy on their innovation performance. The interactions between the firms’ positions in different dimensions of social structures have been rarely examined in prior research despite the fact that they jointly determine the firms’ opportunities and constraints for acquiring important resources, such as knowledge and information, for their innovation activities. In particular, we argue that the effects of structural holes and status contradict, rather than complement, each other because one tends to interfere with the other. We empirically test our theory and hypotheses by analysing the patterns of patent applications and strategic alliances in the US biotechnology industry between 1981 and 2006. While the results support the positive relationship between status and innovation, it is shown that access to structural holes does not significantly affect the biotech firms’ innovation performance on average. Our findings show that the positive effects of structural holes tend to be relatively stronger among lower-status firms, whereas the negative effects become stronger as the firms’ status increases. Finally, we discuss the implications and contributions of this study.
Orthographic Knowledge Promotes Young Chinese Children’s Character Writing Performance

Abstract The present study aimed at developing young children’s knowledge of the structure and function of orthographic components of Chinese characters and words. Grade 2, eight-year-old Chinese children (N = 541) were taught a twelve-week training programme in two quasi experimental conditions: analytic and synthetic approach (ASA), and integrated analytic and synthetic approach (INA). A traditional memorisation and drill approach (TRA) was the control condition. MANOVAs and hierarchical multiple regression analyses showed the INA was more effective as compared with the ASA and the TRA in the post-training character writing performance. The groups performed differentially in the eight bujian (‘radical’ components) processing tasks as indicators of their character and word writing performance. A confirmatory factor analysis found these eight indicator tasks subserved well the three latent constructs of Word Form Retrieval, Bujian Analysis and Synthesis and Bujian Compounding. Bujian analysis and synthesis are emphasised in the character-centred approach in learning and teaching Chinese lexical items.
Out-Of-order execution of synchronous data-flow networks

Data flow process networks (DPNs) have been introduced as a convenient model of computation for distributed and asynchronous systems since each process node can work independently of the other nodes, i. e. without the need of a global coordination. Synchronous and cyclo-static data flow process networks even allow to derive at compile-time efficient static schedules that allow one to run these systems with an efficient use of available resources, e. g. in embedded systems. Single process nodes of DPNs are stream-based computing devices that transform input streams to uniquely defined corresponding output streams such that single values of the output streams are computed as soon as sufficient input values are available. In this sense, they are related to the execution of an instruction stream by a conventional microprocessor. In this paper, we show how out-of-order execution that has been introduced for the efficient use of multiple functional units in microprocessors can also be used for the implementation of DPNs on multiprocessors. This way, the implementation of DPNs on multiprocessors allows one to optimize the throughput of single process nodes, and as shown by our experiments, also of the entire DPN.
Comparison of DMSA Scan 99 m and EC Scan 99 m in Diagnosis of Cortical Defect and Differential Renal Function

Introduction: Diagnosis of renal cortical lesions by radioisotopes in nuclear medicine is one of the most common techniques and procedures can be performed by different radiotracer. However, all these materials are accurate in determining kidney function, but there are differences between them in the field. The purpose of this study was to evaluate the effectiveness of EC scans compared with DMSA scan in the detection of cortical lesions and DRF. Methods: 65 cases, which have been referred for various reasons, for DMSA scans were enrolled. Patients 1 week after DMSA scan with the previous consent of the EC being scanned. The results were compared in terms of convergence as well as sensitivity, specificity, positive and negative predictive value of EC with respect to the results of DMSA scan. Results: PPV of EC was 100%, negative predictive value of EC was 68.75%, sensitivity of EC was 90.74% and specificity of EC was 100% in the detection of cortical lesions. DMSA scan and EC convergence rates result in cortical lesions in our study was high. Discussion: We suggest EC scan as an alternative to reduce the cost of therapy and radiation, but considering the benefits of DMSA scan, it could remain the gold standard method of diagnosis.
Reducing Group Alignment in Factual Disputes? The Limited Effects of Social Identity Interventions

Public divisions over contested science often arise due to individuals’ motivation to hold beliefs in line with others with whom they share a common social identity. To reduce the influence of threatened group identities, this research tests two potential interventions at the point of exposure to new information: self-affirmation and multiple identity salience manipulation. Experiments across dispute contexts—a toxic mining spill, a biofuels mandate, and gene editing technology—show limited support for either intervention reducing group alignment. Together, these results contribute to a growing body of work illuminating the limits of social identity interventions.
Patients' inability to perform a preoperative cardiopulmonary exercise test or demonstrate an anaerobic threshold is associated with inferior outcomes after major colorectal surgery.

BACKGROUND Surgical patients with poor functional capacity, determined by oxygen consumption at anaerobic threshold (AT) during cardiopulmonary exercise testing (CPET), experience longer hospital stays and worse short- and medium-term survival. However, previous studies excluded patients who were unable to perform a CPET or who failed to demonstrate an AT. We hypothesized that such patients are at risk of inferior outcomes after elective surgery. METHODS All patients undergoing major colorectal surgery attempted CPET to assist in the planning of care. Patients were stratified by their test results into Fit (AT ≥ 11.0 ml O2 kg(-1) min(-1)), Unfit (AT < 11.0 ml O2 kg(-1) min(-1)), or Unable to CPET groups (failed to pedal or demonstrate an AT). For each group, we determined hospital stay and mortality. RESULTS Between March 2009 and April 2010, 269 consecutive patients were screened, and proceeded to bowel resection. Median hospital stay was 8 days (IQR 5.1-13.4) and there were 44 deaths (16%) at 2 yr; 26 (9.7%) patients were categorized as Unable to CPET, 69 (25.7%) Unfit and 174 (64.7%) Fit. There were statistically significant differences between the three groups in hospital stay [median (IQR) 14.0 (10.5-23.8) vs 9.9 (5.5-15) vs 7.1 (4.9-10.8) days, P < 0.01] and mortality at 2 yr [11/26 (42%) vs 14/69 (20%) vs 19/174 (11%), respectively (P < 0.01)] although the differences between Unable and Unfit were not statistically different. CONCLUSIONS Patients' inability to perform CPET is associated with inferior outcomes after major colorectal surgery. Future studies evaluating CPET in risk assessment for major surgery should report outcomes for this subgroup.
Partial substitution of the ureter using a double short segments of the ileum following the monti procedure

The partial substitution of the ureter using a pediculated double short segments of the ileum is a technique used to re-establish ureteral transit and preserve the renal unit, following the resection of extensive ureteral lesions. Standard surgical procedure for an ileoureteroplasty consists of isolating an ileal duct of equal or greater length than the ureteral defect and interposing it in the urinary tract in an isoperistaltic direction. Monti described a surgical technique that allows for the creation of catheterizable stomas in continent urinary diversions, using the Mitrofanoff principle. These passageways were created from one or several 2.5 cm long ileal sections by means of their detubulization and transverse retubulization.
A New Generalization of Fibonacci Sequence & Extended Binet's Formula

Abstract Consider the Fibonacci sequence having initial conditions F 0 = 0, F 1 = 1 and recurrence relation Fn = F n–1 + F n–2 (n ≥ 2). The Fibonacci sequence has been generalized in many ways, some by preserving the initial conditions, and others by preserving the recurrence relation. In this article, we study a new generalization {qn }, with initial conditions q 0 = 0 and q 1 = 1 which is generated by the recurrence relation qn = aq n–1 + q n–2 (when n is even) or qn = bq n–1 + q n–2 (when n is odd), where a and b are nonzero real numbers. Some well-known sequences are special cases of this generalization. The Fibonacci sequence is a special case of {qn } with a = b = 1. Pell's sequence is {qn } with a = b = 2 and the k-Fibonacci sequence is {qn } with a = b = k. We produce an extended Binet's formula for the sequence {qn } and, thereby, identities such as Cassini's, Catalan's, d'Ocagne's, etc.
In situ studies of the primary immune response to (4-hydroxy-3- nitrophenyl)acetyl. IV. Affinity-dependent, antigen-driven B cell apoptosis in germinal centers as a mechanism for maintaining self- tolerance

Germinal centers (GCs) are the sites of antigen-driven V(D)J gene hypermutation and selection necessary for the generation of high affinity memory B lymphocytes. Despite the antigen dependence of this reaction, injection of soluble antigen during an established primary immune response induces massive apoptotic death in GC B cells, but not in clonally related populations of nonfollicular B lymphoblasts and plasmacytes. Cell death in GCs occurs predominantly among light zone centrocytes, is antigen specific, and peaks within 4-8 h after injection. Antigen-induced programmed death does not involve cellular interactions mediated by CD40 ligand (CD40L) or Fas; disruption of GCs by antibody specific for CD40L was not driven by apoptosis and C57BL/6.lpr mice, though unable to express the Fas death trigger, remained fully susceptible to soluble antigen. Single injections of antigen did not significantly decrease GC numbers or average size, but repeated injections during an 18-h period resulted in fewer and substantially smaller GCs. As cell loss appeared most extensive in the light zone, decreased GC cellularity after prolonged exposure to soluble antigen implies that the Ig- centroblasts of the dark zone may require replenishment from light zone cells that have survived antigenic selection. GC cell death is avidity-dependent; oligovalent antigen induced relatively little apoptosis and GC B cells that survived long exposures to multivalent antigen expressed atypical VDJ rearrangements unlikely to encode high affinity antibody. Antigen- induced apoptotic death in GCs may represent a mechanism for the peripheral deletion of autoreactive B cell mutants much as the combinatorial repertoire of immature B lymphocytes is censored in the bone marrow.
The Nuances of Brand Personality: A Corpus-assisted Linguistic Analysis of Web-based Communications of Fashion Brands

The ability to establish a particular brand personality (i.e. a set of human personality traits that consumers associate with a brand) is a key component of fashion brand management and communication. A given fashion brand may use language that communicates different personality traits (e.g. glamourous, exciting, youthful, exotic) as a way to define its own personality and distinguish itself from other fashion brands. Based on a corpus consisting of company-produced texts collected from the websites and Facebook pages of over 100 fashion brands, this study aimed to determine which traits of brand personality emerge, which are the most frequent, and which nuances of meaning can be identified within them. This was accomplished by means of text analysis software that identifies statistically significant semantic domains to which conceptually-related lexical items are assigned. The analysis revealed 14 key semantic domains that were linked to various brand personality traits. Among the most prominent were Judgement of appearance: Positive, Time: New and young, Relationship: Intimacy and sex, and Unexpected, highlighting not only the traditional importance attributed to attractiveness, but also to sensuality and non-conventionality as desirable traits of fashion brand personality. Other distinctive traits that emerged as significant involved exclusivity (encoding the value of elitism) and iconicity (emphasizing high stature and uniqueness). The study offers insights into how fashion brands utilize web-based communications to convey brand personality. It also offers a useful methodology that fashion companies can adapt to ensure that they are effectively communicating the intended brand personality.
Effects of MYCN antisense oligonucleotide administration on tumorigenesis in a murine model of neuroblastoma.

BACKGROUND Human MYCN (hMYCN) oncogene amplification is a powerful predictor of treatment failure in childhood neuroblastoma, and dysregulation of hMYCN protein expression appears to be critically involved in the pathogenesis of this disease. We used hMYCN antisense (AS) oligonucleotides to investigate, both in vitro and in vivo, the therapeutic potential of inhibiting hMYCN expression. METHODS We transiently transfected human neuroblastoma IMR-32 cells, which have an amplified hMYCN gene, with fluorescently labeled hMYCN AS or scrambled (SCR) control oligonucleotides and used fluorescence-activated cell sorting to enrich for cell populations containing different levels of the oligonucleotides. We used fluorescence immunocytochemistry or reverse transcription polymerase chain reaction to assay gene expression levels and trypan blue exclusion to assay growth inhibition in the cell populations. We examined the effects of continuous treatment for 6 weeks with AS or SCR oligonucleotides via subcutaneously implanted microosmotic pumps on tumor growth in a transgenic mouse model of hMYCN-induced neuroblastoma (n = 20 mice per group). All statistical tests were two-sided. RESULTS IMR-32 cells treated with AS oligonucleotides had approximately half as much hMYCN protein and cell proliferation as either SCR oligonucleotide-transfected or mock-transfected controls; the differences were statistically significant. Transgenic mice treated with AS oligonucleotides had lower tumor incidence and statistically significantly lower tumor mass than SCR-treated or untreated control mice. Compared with control treatments, AS oligonucleotide treatment in vitro and in vivo was associated with decreased expression of hMYCN and putative hMYCN target genes but not with that of closely related genes. Several AS oligonucleotide-treated mice developed tumors contralateral to the site of oligonucleotide administration, whereas SCR oligonucleotide-treated or untreated mice displayed bilateral tumor growth. CONCLUSIONS Decreased expression of hMYCN protein is achievable with the use of AS oligonucleotide treatment, even in the presence of hMYCN oncogene amplification. Antisense strategies targeting the hMYCN oncogene in vivo decrease mouse neuroblastoma tumorigenesis. Investigation of their clinical effect in children with neuroblastoma is warranted.