Miracle-dz/UniFAR-FTUs huggingface dataset:
Time-dependent viscoelastic properties along rat small intestine.

AIM To measure the time-dependent (viscoelastic) behavior in the change of the small intestinal opening angle and to test how well the behavior could be described by the Kelvin model for a standard linear solid. METHODS Segments from the duodenum, jejunum, and ileum were harvested from 10 female Wistar rats and the luminal diameter, wall thickness, and opening angle over time (theta(t)) were measured from rings cut from these segments. RESULTS Morphometric variations were found along the small intestine with an increase in luminal area and a decrease in wall thickness from the duodenum to the ileum. The opening angle obtained after 60 min was highest in the duodenum (220.8+/-12.9 degrees) and decreased along the length of the intestine to 143.9+/-8.9 degrees in the jejunum and 151.4+/-9.4 degrees in the ileum. The change of opening angle as a function of time, fitted well to the Kelvin model using the equation theta(t)/theta(o) = [-eta exp (-lambda t)] after the ring was cut. The computed creep rate lambda did not differ between the segments. Compared to constant calculated from pig aorta and coronary artery, it showed that alpha agreed well (within 5%), eta was three times larger than that for vascular tissue, and lambda ranged +/-40% from the value of the pig coronary artery and was a third of the value of pig aorta. CONCLUSION The change of opening angle over time for all the small intestine segments fits well to the standard linear spring-dashpot model. This viscoelastic constant of the rat small intestine is fairly homogenous along its length. The data obtained from this study add to a base set of biomechanical data on the small intestine and provide a reference state for comparison to other tissues, diseased intestinal tissue or intestinal tissue exposed to drugs or chemicals.
Novel FOXC2 Mutation in Hereditary Distichiasis Impairs DNA-Binding Activity and Transcriptional Activation

Distichiasis presents as double rows of eyelashes arising from aberrant differentiation of the meibomian glands of the eyelids, and it may be sporadic or hereditary. FOXC2 gene mutations in hereditary distichiasis are rarely reported. Here, we examined two generations of a Chinese family with hereditary distichiasis but without lymphedema or other features of LD syndrome. The FOXC2 gene was amplified and sequenced in all family members. Subcellular localization and luciferase assays were performed to assess the activity of the mutant FOXC2 protein. Clinical examinations showed distichiasis, lower eyelid ectropion, congenital ptosis and photophobia in all affected individuals. Sequence analysis revealed a novel frameshift mutation, c. 964_965insG, in the coding region of the FOXC2 gene. This mutation caused protein truncation due to the presence of a premature stop codon. A fluorescence assay showed that this mutation did not change the nuclear localization of the protein. However, it impaired DNA-binding activity and decreased transcriptional activation. This is the first report of a FOXC2 mutation in hereditary distichiasis in the Chinese population. The findings of our study expand the FOXC2 mutation spectrum and contribute to the understanding of the genotype-phenotype correlation of this disease.
Visual response properties of neurons in the LGN of normally reared and visually deprived macaque monkeys.

It is now well appreciated that parallel retino-geniculo-cortical pathways exist in the monkey as in the cat, the species in which parallel visual pathways were first and most thoroughly documented. What remains unclear is precisely how many separate pathways pass through the parvo- and magnocellular divisions of the macaque lateral geniculate nucleus (LGN), what relationships-homologous or otherwise-these pathways have to the cat's X, Y, and W pathways, and whether these are affected by visual deprivation. To address these issues of classification and trans-species comparison, we used achromatic stimuli to obtain an extensive set of quantitative measurements of receptive field properties in the parvo- and magnocellular laminae of the LGN of nine macaque monkeys: four normally reared and five monocularly deprived of vision by lid suture near the time of birth. In agreement with previous studies, we find that on average magnocellular neurons differ from parvocellular neurons by having shorter response latencies to optic chiasm stimulation, greater sensitivity to luminance contrast, and better temporal resolution. Magnocellular laminae are also distinguished by containing neurons that summate luminance over their receptive fields nonlinearly (Y cells) and whose temporal response phases decrease with increasing stimulus contrast (indicative of a contrast gain control mechanism). We found little evidence for major differences between magno- and parvocellular neurons on the basis of most spatial parameters except that at any eccentricity, the neurons with the smallest receptive field centers tended to be parvocellular. All parameters were distributed unimodally and continuously through the parvo- and magnocellular populations, giving no indications of subpopulations within each division. Monocular deprivation led to clear anatomical effects: cells in deprived-eye laminae were pale and shrunken compared with those in nondeprived eye laminae, and Cat-301 immunoreactivity in deprived laminae was essentially uniformly abolished. However, deprivation had only subtle effects on the response properties of LGN neurons. Neurons driven by the deprived eye in both magno- and parvocellular laminae had lower nonlinearity indices (i.e., summed signals across their receptive fields more linearly) and were somewhat less responsive. In magnocellular laminae driven by the deprived eye, neuronal response latencies to stimulation of the optic chiasm were slightly shorter than those in the nondeprived laminae, and receptive field surrounds were a bit stronger. No other response parameters were affected by deprivation, and there was no evidence for loss of a specific cell class as in the cat.
Variables associated with peripherally inserted central catheter related infection in high risk newborn infants 1

OBJECTIVE: to relate the variables from a surveillance form for intravenous devices in high risk newborn infants with peripherally inserted central catheter related infection. METHODOLOGY: approximately 15 variables were studied, being associated with peripherally inserted central catheter related infection, this being defined by blood culture results. The variables analyzed were obtained from the surveillance forms used with intravenous devices, attached to the medical records of newborn infants weighing between 500 and 1,499 g. The statistical association was defined using the Chi-squared and Student t tests. The study was approved by the Research Ethics Committee of the Instituto Fernandes Figueira under process N. 140.703/12. RESULTS: 63 medical records were analyzed. The infection rate observed was 25.4%. Of the variables analyzed, only three had a statistically-significant relationship with the blood culture - the use of drugs capable of inhibiting acid secretion, post-natal steroid use, and undertaking more than one invasive procedure (p-value of 0.0141, 0.0472 and 0.0277, respectively). CONCLUSION: the absence of significance of the variables of the form may be related to the quality of the records and to the absence of standardization. It is recommended that the teams be encouraged to adhere to the protocol and fill out the form.
The Changing Microbial Epidemiology in Cystic Fibrosis

SUMMARY Infection of the airways remains the primary cause of morbidity and mortality in persons with cystic fibrosis (CF). This review describes salient features of the epidemiologies of microbial species that are involved in respiratory tract infection in CF. The apparently expanding spectrum of species causing infection in CF and recent changes in the incidences and prevalences of infection due to specific bacterial, fungal, and viral species are described. The challenges inherent in tracking and interpreting rates of infection in this patient population are discussed.
Dividends Distribution and Earnings Persistence: Evidence from Chinese Listed Companies

Dividends distribution of Chinese listed companies is irregular, and the level of dividends can’t match that of earnings persistence. This paper empirically investigates the relationship between dividends distribution, including payout policy and level of cash dividends, and earnings persistence. Different from current literature, this paper is the first to investigate the relationship between dividends and earnings persistence from the perspective of different earnings components. New findings of this paper are as follows. First, the company which distributed dividends, has a stronger earnings persistence than those not. Second, core earnings persistence of listed companies that distributed dividends is significantly stronger than non-core earnings persistence. In addition, the company which distributed cash dividends, has a stronger earnings persistence than those just paid stock dividends, and the higher the level of cash dividends is, the stronger earnings persistence shows. These findings have implications for Chinese listed companies to improve earnings persistence by increasing operating income, and for the guidance of properly developing the company cash dividends distribution policy according to its core earnings persistence.
Genomic Plasticity in Natural Populations ofBordetella pertussis

ABSTRACT We determined the genomic organization of 14 clinical strains ofBordetella pertussis isolated over an 18-month period in Alberta, Canada. The maps of these 14 strains, while demonstrating general similarity of gene order, display a number of examples of genomic rearrangements in the form of large chromosomal inversions.
Numerical and Linguistic Prediction of Time Series With the Use of Fuzzy Cognitive Maps

In this paper, we introduce a novel approach to time-series prediction realized both at the linguistic and numerical level. It exploits fuzzy cognitive maps (FCMs) along with a recently proposed learning method that takes advantage of real-coded genetic algorithms. FCMs are used for modeling and qualitative analysis of dynamic systems. Within the framework of FCMs, the systems are described by means of concepts and their mutual relationships. The proposed prediction method combines FCMs with granular, fuzzy-set-based model of inputs. One of their main advantages is an ability to carry out modeling and prediction at both numerical and linguistic levels. A comprehensive set of experiments has been carried out with two major goals in mind. One is to assess quality of the proposed architecture, the other to examine the influence of its parameters of the prediction technique on the quality of prediction. The obtained results, which are compared with other prediction techniques using fuzzy sets, demonstrate that the proposed architecture offers substantial accuracy expressed at both linguistic and numerical levels.
In-Depth Mutational Analysis of the Promyelocytic Leukemia Zinc Finger BTB/POZ Domain Reveals Motifs and Residues Required for Biological and Transcriptional Functions

ABSTRACT The promyelocytic leukemia zinc finger (PLZF) protein is a transcription factor disrupted in patients with t(11;17)(q23;q21)-associated acute promyelocytic leukemia. PLZF contains an N-terminal BTB/POZ domain which is required for dimerization, transcriptional repression, formation of high-molecular-weight DNA-protein complexes, nuclear sublocalization, and growth suppression. X-ray crystallographic data show that the PLZF BTB/POZ domain forms an obligate homodimer via an extensive interface. In addition, the dimer possesses several highly conserved features, including a charged pocket, a hydrophobic monomer core, an exposed hydrophobic surface on the floor of the dimer, and two negatively charged surface patches. To determine the role of these structures, mutational analysis of the BTB/POZ domain was performed. We found that point mutations in conserved residues that disrupt the dimer interface or the monomer core result in a misfolded nonfunctional protein. Mutation of key residues from the exposed hydrophobic surface suggests that these are also important for the stability of PLZF complexes. The integrity of the charged-pocket region was crucial for proper folding of the BTB/POZ domain. In addition, the pocket was critical for the ability of the BTB/POZ domain to repress transcription. Alteration of charged-pocket residue arginine 49 to a glutamine (mutant R49Q) yields a domain that can still dimerize but activates rather than represses transcription. In the context of full-length PLZF, a properly folded BTB/POZ domain was required for all PLZF functions. However, PLZF with the single pocket mutation R49Q repressed transcription, while the double mutant D35N/R49Q could not, despite its ability to dimerize. These results indicate that PLZF requires the BTB/POZ domain for dimerization and the charged pocket for transcriptional repression.
Ultrafast Magnetization Manipulation Using Single Femtosecond Light and Hot‐Electron Pulses

Current‐induced magnetization manipulation is a key issue for spintronic applications. This manipulation must be fast, deterministic, and nondestructive in order to function in device applications. Therefore, single‐ electronic‐pulse‐driven deterministic switching of the magnetization on the picosecond timescale represents a major step toward future developments of ultrafast spintronic systems. Here, the ultrafast magnetization dynamics in engineered Gdx[FeCo]1−x‐based structures are studied to compare the effect of femtosecond laser and hot‐electron pulses. It is demonstrated that a single femtosecond hot‐electron pulse causes deterministic magnetization reversal in either Gd‐rich and FeCo‐rich alloys similarly to a femtosecond laser pulse. In addition, it is shown that the limiting factor of such manipulation for perpendicular magnetized films arises from the formation of a multidomain state due to dipolar interactions. By performing time‐resolved measurements under various magnetic fields, it is demonstrated that the same magnetization dynamics are observed for both light and hot‐electron excitation, and that the full magnetization reversal takes place within 40 ps. The efficiency of the ultrafast current‐induced magnetization manipulation is enhanced due to the ballistic transport of hot electrons before reaching the GdFeCo magnetic layer.
Group motion editing

Animating a crowd of characters is an important problem in computer graphics. The latest techniques enable highly realistic group motions to be produced in feature animation films and video games. However, interactive methods have not emerged yet for editing the existing group motion of multiple characters. We present an approach to editing group motion as a whole while maintaining its neighborhood formation and individual moving trajectories in the original animation as much as possible. The user can deform a group motion by pinning or dragging individuals. Multiple group motions can be stitched or merged to form a longer or larger group motion while avoiding collisions. These editing operations rely on a novel graph structure, in which vertices represent positions of individuals at specific frames and edges encode neighborhood formations and moving trajectories. We employ a shape-manipulation technique to minimize the distortion of relative arrangements among adjacent vertices while editing the graph structure. The usefulness and flexibility of our approach is demonstrated through examples in which the user creates and edits complex crowd animations interactively using a collection of group motion clips.
Prevention of colorectal cancer: an emerging role for high-dose vitamin D supplementation?

Colorectal cancer is the second most common cause of cancer death in the United States. It is estimated that about 55,000 patients will die this year due to advanced colorectal cancer. These grim statistics persist despite a marked increase in the rate of screening colonoscopies and improvements in adjuvant chemotherapy. Successful chemoprevention strategies may reduce the risk of new colorectal cancers, thus decreasing related overall morbidity and mortality.
Investigating the Healthiness of Internet-Sourced Recipes: Implications for Meal Planning and Recommender Systems

Food recommenders have the potential to positively influence the eating habits of users. To achieve this, however, we need to understand how healthy recommendations are and the factors which influence this. Focusing on two approaches from the literature (single item and daily meal plan recommendation) and utilizing a large Internet sourced dataset from Allrecipes.com, we show how algorithmic solutions relate to the healthiness of the underlying recipe collection. First, we analyze the healthiness of Allrecipes.com recipes using nutritional standards from the World Health Organisation and the United Kingdom Food Standards Agency. Second, we investigate user interaction patterns and how these relate to the healthiness of recipes. Third, we experiment with both recommendation approaches. Our results indicate that overall the recipes in the collection are quite unhealthy, but this varies across categories on the website. Users in general tend to interact most often with the least healthy recipes. Recommender algorithms tend to score popular items highly and thus on average promote unhealthy items. This can be tempered, however, with simple post-filtering approaches, which we show by experiment are better suited to some algorithms than others. Similarly, we show that the generation of meal plans can dramatically increase the number of healthy options open to users. One of the main findings is, nevertheless, that the utility of both approaches is strongly restricted by the recipe collection. Based on our findings we draw conclusions how researchers should attempt to make food recommendation systems promote healthy nutrition.
One tagger, many uses: Illustrating the power of ontologies in dictionary-based named entity recognition

Automatic annotation of text is an important complement to manual annotation, because the latter is highly labour intensive. We have developed a fast dictionary-based named entity recognition (NER) system and addressed a wide variety of biomedical problems by applied it to text from many different sources. We have used this tagger both in real-time tools to support curation efforts and in pipelines for populating databases through bulk processing of entire Medline, the open-access subset of PubMed Central, NIH grant abstracts, FDA drug labels, electronic health records, and the Encyclopedia of Life. Despite the simplicity of the approach, it typically achieves 80–90% precision and 70–80% recall. Many of the underlying dictionaries were built from open biomedical ontologies, which further facilitate integration of the text-mining results with evidence from other sources.
In Vivo Whole-Cell Recording of Odor-Evoked Synaptic Transmission in the Rat Olfactory Bulb

One of the first steps in the coding of olfactory information is the transformation of synaptic input to action potential firing in mitral and tufted (M/T) cells of the mammalian olfactory bulb. However, little is known regarding the synaptic mechanisms underlying this process in vivo. In this study, we examined odor-evoked response patterns of M/T and granule cells using whole-cell recording in anesthetized, freely breathing rats. We find that odor-evoked excitatory responses in M/T cells typically consist of bursts of action potentials coupled to the ∼2 Hz respiration rhythm. Odor-evoked, rhythmic M/T cell excitation is reliable during odor presentation (2–4 sec); in contrast, both excitatory responses of granule cells and M/T cell lateral inhibition adapt quickly after the first respiration cycle in the presence of odorants. We also find that the amplitude and initial slope of odor-evoked synaptic excitation play an important role in regulating the timing of M/T cell spikes. Furthermore, differences in odor concentration alter the shape of odor-evoked excitatory synaptic responses, the latency of M/T cell spikes, and the timing of M/T cell lateral inhibition.
Finding strongly connected components in parallel using O(log2n) reachability queries

We give a randomized (Las-Vegas) parallel algorithm for computing strongly connected components of a graph with n vertices and m edges. The runtime is dominated by <i>O</i>(log<sup>2</sup><i>n</i>) multi-source parallel reachability queries; i.e. <i>O</i>(log<sup>2</sup><i>n</i>) calls to a subroutine that computes the union of the descendants of a given set of vertices in a given digraph. Our algorithm also topologically sorts the strongly connected components. Using Ullman and Yannakakis's [22] techniques for the reachability subroutine gives our algorithm runtime Õ(<i>t</i>) using <i>mn</i>/<i>t</i><sup>2</sup> processors for any (<i>n</i><sup>2</sup>/<i>m)</i><sup>1/3</sup> ≤= <i>t</i> ≤= <i>n</i>. On sparse graphs, this improves the number of processors needed to compute strongly connected components and topological sort within time <i>n</i><sup>1/3</sup> ≤= <i>t</i> ≤= <i>n</i> from the previously best known (<i>n</i>/<i>t</i>)<sup>3</sup> [20] to (<i>n</i>/<i>t</i>)<sup>2</sup>.
The Advantages of Therapeutic Drug Monitoring in Patients Receiving Antiretroviral Treatment and Experiencing Medication-Related Problems

Background:Therapeutic drug monitoring (TDM) of antiretroviral drugs (ARVs) is used to improve the efficacy and safety of ARVs, but there is little interest for the systematic or random TDM of ARVs in the medical management of patients with acquired immune deficiency syndrome. This study aimed to evaluate a different approach and test the potential advantages of TDM as part of medical treatments when clinical problems are identified in human immunodeficiency virus–infected patients. Methods:The authors conducted a prospective, noncontrolled, cohort study on 544 human immunodeficiency virus–positive patients treated either with a protease inhibitor (PI), atazanavir/lopinavir, or with a nonnucleoside reverse transcriptase inhibitor (NNRTI), efavirenz/nevirapine. Patients who had virological failure, clinical signs of toxicity, or a risk of pharmacokinetic interactions were identified as having medication-related problems (MRPs), and they were scheduled for TDM of the PIs or NNRTIs. Cases with drug levels outside the range were subjected to intervention, and a second determination of plasma levels and viral load was scheduled to assess their response to the intervention. Results:Of the 521 treatment courses analyzed, 173 (32.4%) presented at least 1 MRP during the study. The TDM yielded abnormal results in 52.5% of the 198 identified MRP cases (95% CI: 45%-59%). The patients treated with PIs had an increased risk for having drug plasma levels that fell outside the normal range compared to those treated with NNRTIs (relative risk =1.36, 95% CI: 1.04–1.79). The TDM-guided interventions contributed to the resolution of 52.1% of the cases that involved treatment courses with MRPs and abnormal drug plasma levels. Conclusions:MRPs, including therapeutic failure, were common in the patients who were included in the study. A high proportion of the treatment courses involving such MRPs also presented abnormal plasma drug levels. The TDM-guided interventions are advantageous under these situations because they allow the continuation of treatments that would otherwise be substituted by more complex and costly alternatives.