Miracle-dz/UniFAR-FTUs huggingface dataset:
Results of Burr Hole and Open or Closed Suction Drainage for Chronic Subdural Hematomas in Adults

SUMMARY: Chronic subdural hematomas in adults are not technically difficult to treat. They probably constitute one of the most common potentially curable lesions with which the average neurosurgeon deals. Despite this (or perhaps because of it) numerous treatments, radically differing from one another, have been advocated. Fine judgement is called for in deciding whether or not to operate in the first instance, make a flap or one or more burr or twist drill holes, use a drain, employ suction, inflate the brain, leave the bone flap out. In a personal series of 71 chronic subdural hematomas, 46 were treated with a red rubber catheter drain through a burr hole and 23 with a closed system suction drain. The results of this series suggest that closed system suction drainage through a single burr hole is the better of the two techniques. It has important theoretical advantages and the procedure is simple and fast. The complication rate is low and patients have a shortened postoperative hospital stay.
Dissection of a type I interferon pathway in controlling bacterial intracellular infection in mice

Defence mechanisms against intracellular bacterial pathogens are incompletely understood. Our study characterizes a type I IFN‐dependent cell‐autonomous defence pathway directed against Legionella pneumophila, an intracellular model organism and frequent cause of pneumonia. We show that macrophages infected with L. pneumophila produced IFNβ in a STING‐ and IRF3‐ dependent manner. Paracrine type I IFNs stimulated upregulation of IFN‐stimulated genes and a cell‐autonomous defence pathway acting on replicating and non‐replicating Legionella within their specialized vacuole. Our infection experiments in mice lacking receptors for type I and/or II IFNs show that type I IFNs contribute to expression of IFN‐stimulated genes and to bacterial clearance as well as resistance in L. pneumophila pneumonia in addition to type II IFN. Overall, our study shows that paracrine type I IFNs mediate defence against L. pneumophila, and demonstrates a protective role of type I IFNs in in vivo infections with intracellular bacteria.
Pediatric maxillofacial injuries at a Nigerian teaching hospital: a three-year review.

AIM To determine the nature of pediatric maxillofacial injuries, according to etiology and characteristics of patients. MATERIALS AND METHODS The records of patients aged 15 years and below who presented with maxillofacial trauma to the Maxillofacial Clinic of Aminu Kano Teaching Hospital, Kano, Nigeria over a 3-year period were retrospectively examined. Patients' demographic and etiologic factors were obtained and analyzed. A P value of <0.05 was considered significant. RESULTS A total of 160 patients comprising males, 102 (63.8%) and females 58 (36.2%), were seen over the period of study. The age of patients range from 4 months to 15 years, mean 7.07 ± 4.52 years. There was no gender difference in terms of age (P < 0.05). Road traffic accident (RTA) was the most common etiologic factor accounting for 45.0% of cases. This was followed by fall (40.6%). Animal related injury and violence accounted equally for 3.8%. Soft tissue injuries in the form of abrasion, laceration and avulsion accounted for 70.0% of cases. Other anatomical sites included the mandible (16.3%), dento-alveolar fractures(12.5%), and midface (1.3%). CONCLUSION Road traffic accident and falls still remains the leading cause of maxillofacial injuries in children in this part of the globe. There is a need to reinforce existing traffic laws that aimed at minimizing the menace of RTA-related accidents.
Report from IPITA-TTS Opinion Leaders Meeting on the Future of β-Cell Replacement

At the time the first pancreas transplant was performed by Kelly and Lillehei in 1966, insulin therapy for diabetes was generally available but administered in a form that is known today as “conventional therapy. ”1 In this era, as many as half of all juvenile onset diabetics did not reach the age of 55 years. Early mortality from accelerated cardiovascular disease, renal failure, and hypoglycemia-related events were commonplace. The early low success rate and mortality of pancreas transplantation by comparison were also suboptimal. As will be characterized in the succeeding 8 chapters, the outcome of “best medical therapy” with newer forms of insulin and insulin delivery systems along with dramatically improved outcomes of islet and pancreas transplantation and novel β-cell sources hold great promise for those afflicted.
Pathobiology of cancer chemotherapy-induced peripheral neuropathy (CIPN)

Chemotherapy induced peripheral neuropathy (CIPN) is a type of neuropathic pain that is a major dose-limiting side-effect of potentially curative cancer chemotherapy treatment regimens that develops in a “stocking and glove” distribution. When pain is severe, a change to less effective chemotherapy agents may be required, or patients may choose to discontinue treatment. Medications used to alleviate CIPN often lack efficacy and/or have unacceptable side-effects. Hence the unmet medical need for novel analgesics for relief of this painful condition has driven establishment of rodent models of CIPN. New insights on the pathobiology of CIPN gained using these models are discussed in this review. These include mitochondrial dysfunction and oxidative stress that are implicated as key mechanisms in the development of CIPN. Associated structural changes in peripheral nerves include neuronopathy, axonopathy and/or myelinopathy, especially intra-epidermal nerve fiber (IENF) degeneration. In patients with CIPN, loss of heat sensitivity is a hallmark symptom due to preferential damage to myelinated primary afferent sensory nerve fibers in the presence or absence of demyelination. The pathobiology of CIPN is complex as cancer chemotherapy treatment regimens frequently involve drug combinations. Adding to this complexity, there are also subtle differences in the pathobiological consequences of commonly used cancer chemotherapy drugs, viz platinum compounds, taxanes, vincristine, bortezomib, thalidomide and ixabepilone, on peripheral nerves.
Android Application to Assist Visually Impaired with Outfit Coordination

ABSTRACT The paper presents an android based application to assist visually impaired with outfit coordination process. The application helps them to be independent in their decisions while shopping or getting ready for the day. The application matches apparel image input with user's previously saved closet items, then provides the user with the possible matching item suggestions. The matching process is done based on the item outline and dominating colours. In order to develop this application five main components have been developed: 1. Two through analogous and complementary matching, as opposed to Region of interest (ROI) extraction components facilitating feature and colour extraction; 2. An outline detection component to determine whether an item is a top, skirt or a pair of trousers; 3. A colour recognition component to extract dominant colours of an apparel image; 4. A descriptive colour verbal feedback; 5. A matching component based on item outline and colours to coordinate with others in the user‟s closet. The output to the user includes the descriptive colours, communicated via audio, indicating the 3 dominant colours using their descriptive names - selected from a pool of 581 different colour shades. Other output is the outline details of the matching items. The application was developed and tested on Android 2.2 (Froyo) and the results showed that the ROI extraction and outline detection components perform well. The colour recognition and descriptive name generation modules outperforms the current ones.
Optimal Rates for Random Fourier Features

Kernel methods represent one of the most powerful tools in machine learning to tackle problems expressed in terms of function values and derivatives due to their capability to represent and model complex relations. While these methods show good versatility, they are computationally intensive and have poor scalability to large data as they require operations on Gram matrices. In order to mitigate this serious computational limitation, recently randomized constructions have been proposed in the literature, which allow the application of fast linear algorithms. Random Fourier features (RFF) are among the most popular and widely applied constructions: they provide an easily computable, low-dimensional feature representation for shift-invariant kernels. Despite the popularity of RFFs, very little is understood theoretically about their approximation quality. In this paper, we provide a detailed finite-sample theoretical analysis about the approximation quality of RFFs by (i) establishing optimal (in terms of the RFF dimension, and growing set size) performance guarantees in uniform norm, and (ii) presenting guarantees in Lr (1 ≤ r < ∞) norms. We also propose an RFF approximation to derivatives of a kernel with a theoretical study on its approximation quality.
Syndesmosis injuries in the pediatric and adolescent athlete: an analysis of risk factors related to operative intervention

Purpose To review all paediatric ankle syndesmotic injuries occurring at our institution and identify risk factors associated with operative intervention. Methods Among 22 873 evaluations for ankle trauma, we found 220 children suffering from syndesmotic injuries (incidence: 0.96%). We recorded demographic data, details of the injury, features on examination and treatment variables. Univariable and multivariable logistic regression modelling was performed to identify risk factors associated with operative intervention. Results The mean age at injury was 15.8 years (8.9 to 19.0) with a median follow-up of 13 weeks (IQR 5 to 30 weeks). A sports-related injury was most common (168/220, 76%). A total of 82 of 220 (37%) patients underwent operative fixation, of which 76 (93%) had an associated fibular fracture. Patients undergoing surgery had a higher incidence of swelling and inability to weight bear (p < 0.001). Statistically significant differences were recorded in tibiofibular (TF) clear space, TF overlap and medial clear space (MCS) between the operative and non-operative cohorts (6.0 vs 4.6 mm (p = 0.002), 5.4 vs 6.9 mm (p = 0.004) and 6.4 vs 3.5 mm (p < 0.001)). Multivariable analysis revealed patients with a fracture of the ankle had 44 times the odds of surgical intervention, patients with a closed physis had over five times the odds of surgical intervention and patients with a medial clear space greater than 5 mm had nearly eight times the odds of requiring surgical intervention. Conclusions Operative ankle syndesmotic injuries in the paediatric population are often associated with a closed distal tibial physis and concomitant fibular fracture.
Diffraction by a dielectric half-plane

The problem of diffraction of a plane electromagnetic wave by a dielectric half-plane is reconsidered for solution by utilizing a set of recently developed approximate boundary conditions and the Wiener-Hopf technique. It is observed from the present solution of the problem that reflected waves cease to exist if the angle of incidence takes up the value \tan^{-1}(1/n) where n represents the refractive index of the material of the half-plane under consideration. Expression for the diffracted far field is obtained by using a modification of the saddle point method, and numerical values of the diffraction coefficients are presented in the form of a table for a special value of the refractive index n and for different values of the parameter kh, h representing the (small) thickness of the half-plane and k the wavenumber.
Anterograde or retrograde transsynaptic labeling of CNS neurons with vesicular stomatitis virus vectors

To understand how the nervous system processes information, a map of the connections among neurons would be of great benefit. Here we describe the use of vesicular stomatitis virus (VSV) for tracing neuronal connections in vivo. We made VSV vectors that used glycoprotein (G) genes from several other viruses. The G protein from lymphocytic choriomeningitis virus endowed VSV with the ability to spread transsynaptically, specifically in an anterograde direction, whereas the rabies virus glycoprotein gave a specifically retrograde transsynaptic pattern. The use of an avian G protein fusion allowed specific targeting of cells expressing an avian receptor, which allowed a demonstration of monosynaptic anterograde tracing from defined cells. Synaptic connectivity of pairs of virally labeled cells was demonstrated by using slice cultures and electrophysiology. In vivo infections of several areas in the mouse brain led to the predicted patterns of spread for anterograde or retrograde tracers.
Does the Provision of Healthcare Vary with Race? Evidence from Health Shocks to Patients Far From Home

A vast literature acknowledges that minority groups, particularly African-Americans, receive less, and lower-quality treatment than Caucasians in U.S. health facilities. It remains an open question as to how much of this disparity is a result of poverty, and how much, a result of more overt discrimination. Former empirical studies are far from conclusive given the endogeneity of hospital quality, as minorities are overrepresented in areas served by poor health facilities. To remedy this endogeneity issue, we observe visitors to the state of Florida, as well as travelers within Florida. When an individual experiences a health shock far from home, her hospital assignment becomes random. By contrasting treatment intensity, and patient outcomes of minority visitors with the total population, we find that residence plays a substantial role in the provision of healthcare. Our results indicate that though African-Americans as minority group receive less treatment and experience higher mortality rates, these disparities disappear for African-American visitors.
Crucial role of transient receptor potential ankyrin 1 and mast cells in induction of nonallergic airway hyperreactivity in mice.

RATIONALE Airway hyperreactivity (AHR) is a key feature of bronchial asthma, and inhalation of irritants may facilitate development of nonallergic AHR. Swimmers exposed to hypochlorite (ClO(-))-containing water show a higher risk of developing AHR. We developed a mouse model in which instillation of ClO(-) before ovalbumin (OVA) induces AHR without bronchial inflammatory cells. OBJECTIVES To investigate the mechanisms of ClO(-)-OVA-induced nonallergic AHR. METHODS The involvement of the transient receptor potential ankyrin (TRPA)1 channel was checked in vivo by the use of TRPA1(-/-) mice and in vitro by Ca(2+) imaging experiments. The role of substance P (SP) was investigated by pretreating animals with the receptor antagonist RP67580, by replacing ClO(-) with SP in vivo, and by immunofluorescent staining of large airways of exposed mice. The role of mast cells was evaluated by exposing mast cell-deficient Kit(Wh)/Kit(Wsh) mice to ClO(-)-OVA with or without mast cell reconstitution. MEASUREMENTS AND MAIN RESULTS ClO(-)-OVA did not induce AHR in TRPA1(-/-) mice, and ClO(-) generates a Ca(2+) influx in TRPA1-transfected cells. Pretreatment with RP67580 reduces ClO(-)-OVA-induced AHR, although no increased SP expression was shown in the airways. SP-OVA exposure resulted in the same AHR as induced by ClO(-)-OVA. Kit(Wsh)/Kit(Wsh) mice did not develop AHR in response to ClO(-)-OVA unless they were reconstituted with bone marrow-derived mast cells. CONCLUSIONS Induction of AHR by exposure to ClO(-)-OVA depends on a neuroimmune interaction that involves TRPA1-dependent stimulation of sensory neurons and mast cell activation.
An investigation into the impact of controlled English rules on the comprehensibility, usefulness and acceptability of machine-translated technical documentation for French and German users

Previous studies suggest that the application of Controlled Language (CL) rules can significantly improve the readability, consistency, and machine-translatability of source text. One of the justifications for the application of CL rules is that they can have a similar impact on several target languages by reducing the post-editing effort required to bring Machine Translation (Ml’) output to acceptable quality. In certain situations, however, post-editing services may not always be a viable solution. Web-based information is often expected to be made available in real-time to ensure that its access is not restricted to certain users based on their locale. Uncertainties remain with regard to the actual usefulness of MT output for such users, as no empirical study has examined the impact of CL rules on the usefulness, comprehensibility, and acceptability of MT technical documents from a Web user's perspective. In this study, a two-phase approach is used to determine whether Controlled English rules can have a significant impact on these three variables. First, individual CL rules are evaluated within an experimental environment, which is loosely based on a test suite.Two documents are then published and subject to a randomised evaluation within the framework of an online experiment using a customer satisfaction questionnaire. The findings indicate that a limited number of CL rules have a similar impact on the comprehensibility of French and German output at the segment level. The results of the online experiment show that the application of certain CL rules has the potential to significantly improve the comprehensibility of German MT technical documentation. Our findings also show that the introduction of CL rules did not lead to any significant improvement of the comprehensibility, usefulness, and acceptability of French MT technical documentation.
Microbiota Replacement Therapies: Innovation in Gastrointestinal Care

There has been an increasing interest in the association between human disease and altered gut microbiota, and therapeutics to modulate microbiota to treat disease. Healthy human gastrointestinal microbiota is highly diverse and rich, and harbors between 500 and 2,000 species. Diseases associated with dysbiotic microbiota include antibiotic‐associated diarrhea, Clostridium difficile infection, multidrug‐resistant organisms, inflammatory bowel disease, obesity, metabolic syndrome, diabetes mellitus, neuropsychiatric diseases, and systemic autoimmune diseases. Microbiota replacement therapies have shown immense promise in treatment of recurrent C. difficile infection and are being studied for other indications. Microbiota replacement therapies for indications other than C. difficile infection should be performed only in research settings. There is an immense need for standardized microbiota replacement therapies for C. difficile infection. Studies are needed to elucidate long‐term safety and adverse events from these therapies.
The Impact of Conventional and Unconventional Monetary Policy on Investor Sentiment

This paper examines the relationship between monetary policy and investor sentiment across conventional and unconventional monetary policy regimes. During conventional times, we find that a surprise decrease in the fed funds rate leads to a large increase in investor sentiment. Similarly, when the fed funds rate is at its zero lower bound, research results indicate that expansionary unconventional monetary policy shocks also have a large and positive impact on investor mood. Together, our findings highlight the importance of both conventional and unconventional monetary policy in the determination of investor sentiment.
A Wideband Spatial Channel Model for System-Wide Simulations

A wideband space-time channel model is defined, which captures the multiple dependencies and variability in multicell system-wide operating environments. The model provides a unified treatment of spatial and temporal parameters, giving their statistical description and dependencies across a large geographical area for three outdoor environments pertinent to third-generation cellular system simulations. Parameter values are drawn from a broad base of recently published wideband and multiple-antenna measurements. A methodology is given to generate fast-fading coefficients between a base station and a mobile user based on the summation of directional plane waves derived from the statistics of the space-time parameters. Extensions to the baseline channel model, such as polarized antennas, are given to provide a greater variety of spatial environments. Despite its comprehensive nature, the model's implementation complexity is reasonable so it can be used in simulating large-scale systems. Output statistics and capacities are used to illustrate the main characteristics of the model
INTERFERON ALPHA‐2b TREATMENT OF CHRONIC POST‐TRANSFUSION NON‐A, NON‐B HEPATITIS: INTERIM RESULTS OF A RANDOMIZED CONTROLLED OPEN STUDY

32 patients with biopsy-proven chronic non-A, non-B posttransfusion hepatitis and raised aminotransferase levels since more than 1 year were randomized 2:1 to treatment with interferon alpha-2b, Introna, or to controls. The interferon group received 3 MU interferon 3 times weekly subcutaneously. Interim results 12 weeks after randomization showed that 14/21 (67%) patients in the treatment group had normalized their serum alanine aminotransferase levels whereas none of 11 patients in the control group had (p less than 0.001). If interferon alpha-2b is only suppressive during ongoing therapy or curative will be shown later during continued follow-up.
Meta algorithms for hierarchical Web caches

Large scale hierarchical caches for Web content have been deployed widely in an attempt to reduce delivery delays and bandwidth consumption and also to improve the scalability of content dissemination through the World Wide Web. Irrespective of the specific replacement algorithm employed in each cache, a de facto characteristic of contemporary hierarchical caches is that a hit for a document at an l-level cache leads to the caching of the document in all intermediate caches (levels l-1,., 1) on the path towards the leaf cache that received the initial request. This paper presents various algorithms that revises this standard behavior and attempts to be more selective in choosing the caches that gets to store a local copy of the requested document. As these algorithms operate independently of the actual replacement algorithm running in each individual cache, they are referred to as meta algorithms. Three new meta algorithms are proposed and compared against the de facto one and a recently proposed one by means of synthetic and trace-driven simulations. The best of the new meta algorithms appears to be leading to improved performance under most simulated scenarios, especially under a low availability of storage. The latter observation makes the presented meta algorithms particularly favorable for the handling of large data objects such as stored music files or short video clips. Additionally, a simple load balancing algorithm that is based on the concept of meta algorithms is proposed and evaluated. The algorithm is shown to be able to provide for an effective balancing of load thus possibly addressing the recently discovered "filtering-effect" in hierarchical Web caches.
Multilevel ordinal models for examination grades

In multilevel situations graded category responses are often converted to points scores and linear models for continuous normal responses fitted. This is particularly prevalent in educational research. Generalized multilevel ordinal models for response categories are developed and contrasted in some respects with these normal models. Attention is given to the analysis of a large database of the General Certificate of Education Advanced Level examinations in England and Wales. Ordinal models appear to have advantages in facilitating the study of institutional differences in more detail. Of particular importance is the flexibility offered by logit models with nonproportionally changing odds. Examples are given of the richer contrasts of institutional and subgroup differences that may be evaluated. Appropriate widely available software for this approach is also discussed.