Miracle-dz/UniFAR-FTUs huggingface dataset:
The Australian Defence Force Mental Health Prevalence and Wellbeing Study: design and methods

Background The Australian Defence Force (ADF) Mental Health Prevalence and Wellbeing Study (MHPWS) is the first study of mental disorder prevalence in an entire military population. Objective The MHPWS aims to establish mental disorder prevalence, refine current ADF mental health screening methods, and identify specific occupational factors that influence mental health. This paper describes the design, sampling strategies, and methodology used in this study. Method At Phase 1, approximately half of all regular Navy, Army, and Air Force personnel (n=24,481) completed self-report questionnaires. At Phase 2, a stratified sub-sample (n=1,798) completed a structured diagnostic interview to detect mental disorder. Based on data from non-responders, data were weighted to represent the entire ADF population (n=50,049). Results One in five ADF members met criteria for a 12-month mental disorder (22%). The most common disorder category was anxiety disorders (14.8%), followed by affective (9.5%) and alcohol disorders (5.2%). At risk ADF sub-groups were Army personnel, and those in the lower ranks. Deployment status did not have an impact on mental disorder rates. Conclusion This study has important implications for mental health service delivery for Australian and international military personnel as well as contemporary veterans.
Impact of Serum Uric Acid Levels on Coronary Plaque Stability Evaluated Using Integrated Backscatter Intravascular Ultrasound in Patients with Coronary Artery Disease.

AIM Because the prevalence of hyperuricemia is lower in females than in males, the association between hyperuricemia and cardiovascular disease has been frequently reported in females. Increased serum uric acid levels are associated with the presence of cardiovascular risk factors such as hypertension, renal dysfunction, insulin resistance, and metabolic syndrome. However, it is controversial whether hyperuricemia is an independent risk factor for coronary artery disease in both the genders. The purpose of this study was to investigate the relationship between serum uric acid levels and coronary plaque components assessed using integrated backscatter intravascular ultrasound (IB-IVUS) in males and females. METHODS In total, 385 patients (298 males and 87 females) who underwent percutaneous coronary intervention using IB-IVUS were divided into three groups in each gender according to their serum uric acid levels. We characterized tissue from coronary plaques in culprit lesions. RESULTS Serum uric acid levels significantly correlated with percent lipid volume (r=0.37) and inversely correlated with percent fibrous volume (r=－0.35). Multivariate analysis showed that the uric acid level was independently associated with lipid-rich plaques (odds ratio 2.43, 95%, confidence interval 1.75-3.47). The prevalence of lipid-rich plaques increased with increasing uric acid levels in both genders. CONCLUSION Increased serum uric acid levels were associated with larger lipid content plaques in both genders.
Anticyclonic eddies generated near the corner rise seamounts

During 1977 two freely drifting buoys, originally in the Gulf Stream, looped over and in the lee of the Corner Rise seamounts. The trajectories suggest that by mid-August an anti-cyclonic eddy was generated over the seamounts, where it remained for six weeks. During the period October-December it left the seamounts and drifted southwestward with a mean speed of 5 cm/sec. The eddy was characterized by a clockwise circulation with speeds of 30 cm/sec and an overall size of 200 km. An XBT survey showed that the eddy contained a warm core manifested by a depression of the main thermocline; at the center the 15° isotherm was located at a depth of 715 m. During the period June-August a third buoy looped in a second anti-cyclonic eddy which also drifted southwestward in the Jee of the Corner Rise. The implication of these measurements is that, every few months, warm core eddies form near the Corner Rise and that they subsequently drift southwestward forming a wake region downstream of the seamounts.
Evapotranspiration Based Micro Irrigation Scheduling of Tomato Crop under Naturally Ventilated Polyhouse

The present study was undertaken to investigate the Evapotranspiration Based Micro Irrigation Scheduling of Tomato Crop under Naturally Ventilated Polyhouse, at experimental field of Department of Irrigation and Drainage Engineering, G. B. Pant University of Agriculture & Technology, Pantnagar, Uttarakhand during 2017-18. The average of mean monthly ET0 estimated under polyhouse by FAO-PM (benchmark) model was 39.44 mm, but that of the FAO Penman, Hargreaves, Stanghellini, Priestley-Taylor and FAO Radiation models were 38.37, 18.18, 37.80, 48.17 and 53.87 mm, respectively. Whereas, the average of mean monthly ET0 estimated under open environment by FAO-PM (benchmark) model was 116.34 mm, but that of the FAO Penman, Hargreaves, Stanghellini, Priestley-Taylor and FAO Radiation models were 119.33, 133, 126.41, 113.17 and 117.37 mm, respectively. The FAO Penman and Hargreaves model are found to be most and least appropriate models for estimating daily ET0 under polyhouse. Whereas, FAO Radiation and Stanghellini model observed to be most and the least appropriate models in open environment for estimating daily ET0 under polyhouse for the Pantnagar tarai condition of Uttarakhand. During the six month growing period, the average water requirement for tomato crop under polyhouse and open environments were 0.2149 and 0.2924 liter per day per plant, respectively, showing that the water requirement in the open environment was estimated as 30% higher than that of polyhouse. The experimental results also revealed that the treatment T2 (100% water application of ETc without mulch under polyhouse) recorded significant yield (18.97 kg/m2), water use efficiency (135.26 kg/m3) and maximum fruit weight (106.66 gm).
A Phase 3, Randomized, Placebo-controlled Trial of Filgrastim in Patients with Haematological Malignancies Undergoing Matched-related Allogeneic Bone Marrow Transplantation

Introduction Recombinant granulocyte colony-stimulating factor (G-CSF) may aid engraftment post high-dose chemo-/radiotherapy in patients with haematological malignancies undergoing allogeneic bone marrow transplantation (BMT); however, the effects of G-CSF on graft-versus-host disease (GvHD), relapse, and survival are not well defined. Methods In this double-blind, randomized, placebo-controlled, multicentre, phase 3 study, the effects of the G-CSF Filgrastim on neutrophil and platelet recovery, and on clinical outcomes were evaluated. Patients (12–55 years) receiving an allogeneic BMT for a haematological malignancy were randomized to receive Filgrastim 5 µg/kg or placebo. Study treatment was continued until patients achieved an absolute neutrophil count (ANC) ≥0.5 × 109/L, or until day 42. Results Fifty-one patients (Filgrastim, N = 25; placebo, N = 26) were evaluable. Patients treated with Filgrastim had significantly faster engraftment with ANC ≥0.5 × 109/L being achieved after a median (range) of 15.0 (1.0–22.0) days vs. 19.0 (15.0–28.0) days for placebo (P< 0.0001). The incidence of GvHD was comparable for both groups. During the limited follow-up (2 years), Filgrastim had no adverse effect on mortality and possibly reduced the rate of relapse.
Cyclotosaurus naraserluki, sp. nov., a New Late Triassic Cyclotosaurid (Amphibia, Temnospondyli) from the Fleming Fjord Formation of the Jameson Land Basin (East Greenland)

ABSTRACT Cyclotosaurus naraserluki, sp. nov., is a new Late Triassic capitosaurid amphibian from lacustrine deposits in the Fleming Fjord Formation of the Jameson Land Basin in Greenland. It is based on a fairly complete and well-preserved skull associated with two vertebral intercentra. Previously reported as Cyclotosaurus cf. posthumus, C. naraserluki is unique among cyclotosaurs for having the postorbitals embaying the supratemporals posteromedially. The anterior palatal vacuity presents an autapomorphic complete subdivision by a wide medial premaxillary-vomerine bony connection. The parasphenoid projects between the pterygoids and the exoccipitals, preventing a suture between the two, a primitive condition shared with Rhinesuchidae, Eryosuchus, and Kupferzellia. Within Cyclotosaurus, the Greenlandic skull has a distinctive combination of circular choanae (shared with C. ebrachensis, C. posthumus, and C. robustus) and a convex posteromedial margin of the tabulars (also present in C. ebrachensis and C. intermedius). A phylogenetic analysis indicates that C. naraserluki is the sister taxon of the middle Norian C. mordax from southern Germany, with which it shares a pair of premaxillary foramina. Cyclotosaurus is one of the most successful and diverse genera of Late Triassic temnospondyls, with at least eight species reported from middle Carnian to late Norian. Cyclotosaurus naraserluki is the largest amphibian ever reported from Greenland and one of the Late Triassic vertebrates with the highest northern paleolatitude currently known.
Projections from the ventral respiratory group to phrenic and intercostal motoneurons in cat: an autoradiographic study

Anterograde transport of tritiated amino acids (leucine, lysine, and proline) was used to examine the spinal projections of respiratory premotor neurons in the ventral respiratory group (VRG) of cats. This population of neurons corresponds anatomically with the nucleus ambiguus-retroambigualis. Small volumes (20 to 50 nl) of tritiated amino acids were pressure ejected into the middle of the VRG through a micropipette which permitted simultaneous recording of respiratory modulated activity. In two cats injections were made caudal to the obex in regions which contained expiratory modulated neurons. In five cats injections were made rostral to the obex in regions containing inspiratory neurons. After a 2-week survival period, cats were anesthetized and perfused. The entire neuraxis was removed and processed using standard autoradiographic techniques. Transport of tritiated amino acids revealed a marked bilateral projection to lamina IX of the spinal cord at the C4 to C6 level and a primarily contralateral projection to laminae VIII and IX in the thoracic spinal cord. Distinct descending pathways to the phrenic motor neurons were observed in the lateral funiculus and in the ventral funiculus; descending fibers to the intercostal motoneurons in the thoracic cord appeared to be restricted to the ventral funiculus. Labeling of axon terminals in both the cervical and thoracic cords was confined to ventral horn regions which contain motoneurons. These results suggest that monosynaptic projections from brainstem bulbo-spinal neurons to spinal motoneurons are important in controlling respiratory movements of the diaphragm and intercostal muscles.
Deciphering the mechanism behind the varied binding activities of COXIBs through Molecular Dynamic Simulations, MM-PBSA binding energy calculations and per-residue energy decomposition studies

COX-2 is a well-known drug target in inflammatory disorders. COX-1/COX-2 selectivity of NSAIDs is crucial in assessing the gastrointestinal side effects associated with COX-1 inhibition. Celecoxib, rofecoxib, and valdecoxib are well-known specific COX-2 inhibiting drugs. Recently, polmacoxib, a COX-2/CA-II dual inhibitor has been approved by the Korean FDA. These COXIBs have similar structure with diverse activity range. Present study focuses on unraveling the mechanism behind the 10-fold difference in the activities of these sulfonamide-containing COXIBs. In order to obtain insights into their binding with COX-2 at molecular level, molecular dynamics simulations studies, and MM-PBSA approaches were employed. Further, per-residue decomposition of these energies led to the identification of crucial amino acids and interactions contributing to the differential binding of COXIBs. The results clearly indicated that Leu338, Ser339, Arg499, Ile503, Phe504, Val509, and Ser516 (Leu352, Ser353, Arg513, Ile517, Phe518, Val523, and Ser530 in PGHS-1 numbering) were imperative in determining the activity of these COXIBs. The binding energies and energy contribution of various residues were similar in all the three simulations. The results suggest that hydrogen bond interaction between the hydroxyl group of Ser516 and five-membered ring of diarylheterocycles augments the affinity in COXIBs. The SAR of the inhibitors studied and the per-residue energy decomposition values suggested the importance of Ser516. Additionally, the positive binding energy obtained with Arg106 explains the binding of COXIBs in hydrophobic channel deep in the COX-2 active site. The findings of the present work would aid in the development of potent COX-2 inhibitors.
Multithreading: Maximizing On-chip Parallelism

This paper examines simultaneous multithreading, a technique permitting several independent threads to issue instructions to a su-perscalar's multiple functional units in a single cycle. We present several models of simultaneous multithreading and compare them with alternative organizations: a wide superscalar, a fine-grain mul-tithreaded processor, and single-chip, multiple-issue multiprocess-ing architectures. Our results show that both (single-threaded) su-perscalar and fine-grain multithreaded architectures are limited in their ability to utilize the resources of a wide-issue processor. Simultaneous multithreading has the potential to achieve 4 times the throughput of a superscalar, and double that of fine-grain multi-threading. We evaluate several cache configurations made possible by this type of organization and evaluate tradeoffs between them. We also show that simultaneous multithreading is an attractive alternative to single-chip multiprocessors; simultaneous multithreaded processors with a variety of organizations outperform corresponding conventional multiprocessors with similar execution resources. While simultaneous multithreading has excellent potential to increase processor utilization, it can add substantial complexity to the design. We examine many of these complexities and evaluate alternative organizations in the design space.
How Much Remains Undetected? Probability of Molecular Detection of Human Plasmodia in the Field

Background In malaria endemic areas, most people are simultaneously infected with different parasite clones. Detection of individual clones is hampered when their densities fluctuate around the detection limit and, in case of P. falciparum, by sequestration during part of their life cycle. This has important implications for measures of levels of infection or for the outcome of clinical trials. This study aimed at measuring the detectability of individual P. falciparum and P. vivax parasite clones in consecutive samples of the same patient and at investigating the impact of sampling strategies on basic epidemiological measures such as multiplicity of infection (MOI). Methods Samples were obtained in a repeated cross-sectional field survey in 1 to 4.5 years old children from Papua New Guinea, who were followed up in 2-monthly intervals over 16 months. At each follow-up visit, two consecutive blood samples were collected from each child at intervals of 24 hours. Samples were genotyped for the polymorphic markers msp2 for P. falciparum and msp1F3 and MS16 for P. vivax. Observed prevalence and mean MOI estimated from single samples per host were compared to combined data from sampling twice within 24 h. Findings and Conclusion Estimated detectability was high in our data set (0.79 [95% CI 0.76–0.82] for P. falciparum and, depending on the marker, 0.61 [0.58–0.63] or 0.73 [0.71–0.75] for P. vivax). When genotyping data from sequential samples, collected 24 hours apart, were combined, the increase in measured prevalence was moderate, 6 to 9% of all infections were missed on a single day. The effect on observed MOI was more pronounced, 18 to 31% of all individual clones were not detected in a single bleed. Repeated sampling revealed little difference between detectability of P. falciparum and P. vivax.
A multi-centre European study of factors affecting the discharge destination of older people admitted to hospital: analysis of in-hospital data from the ACMEplus project.

OBJECTIVES to examine the relationship between seven predictor variables (recorded on Day 3 of hospital admission) and discharge destination in non-elective medical patients aged 65+ years. DESIGN prospective cohort. SETTING eight centres in six European countries. PREDICTOR VARIABLES age, gender, living alone, physical function (three categories based on Barthel Index), cognition (Katzman's orientation-memory-concentration test), main body system affected (based on International Classification of Diseases), number of geriatric giants (GGs) involved in the referral (a GG being a problem with falling, mobility, continence or cognition). MAIN OUTCOME MEASURES discharge destination (by Day 90) in three categories: 'HOMESAME' (return to previous residence), 'INSTIN90' (discharge to alternative residence or still in hospital at 90 days), 'DEADINHO' (death in hospital), RESULTS in 1,626 patients, discharge destination was HOMESAME in 84.7%, DEADINHO in 8.9% and INSTIN90 in 6.4%. Mean duration of stay was 17.7 days, median 12. Univariate analyses showed a statistically significant relationship between all seven predictor variables and discharge destination. Physical function was the best single predictor with a seven-fold difference in adverse outcome rates between the best and worst categories. On multiple logistic regression, significant predictor variables were as follows. (i) For DEADINHO: physical function, cognition, gender; (ii) for INSTIN90: physical function, living alone, GGs, age, gender. Multiple linear regression identified physical function, GGs and living alone as predictors of loge length of stay. CONCLUSION case-mix systems to compare risk-adjusted hospital outcome in older medical patients need to incorporate information about physical function, cognition and presenting problems in addition to diagnosis.
Booming markets for Moroccan argan oil appear to benefit some rural households while threatening the endemic argan forest

Morocco's argan oil is now the most expensive edible oil in the world. High-value argan markets have sparked a bonanza of argan activity. Nongovernmental organizations, international and domestic development agencies, and argan oil cooperatives aggressively promote the win–win aim of simultaneously benefiting local people and the health of the argan forest. This paper tests some of these win–win claims. Analysis of a panel of detailed household data suggests that the boom has enabled some rural households to increase consumption, increase their goat herds (which bodes poorly for the argan forest), and send their girls to secondary school. The boom has predictably made households vigilant guardians of fruit on the tree, but it has not incited investments in longer term tree and forest health. We evaluate landscape-level impacts of these changes using commune-level data on educational enrollment and normalized difference vegetation index data over the period from 1981 to 2009. The results of the mesoanalysis of enrollment are consistent with the microanalysis: the argan boom seems to have improved educational outcomes, especially for girls. Our normalized difference vegetation index analysis, however, suggests that booming argan prices have not improved the forest and may have even induced degradation. We conclude by exploring the dynamic interactions between argan markets, local institutions, rural household welfare, and forest conservation and sustainability.
Transgenic Mice T Cell Responses in TCR + as well as CD8 + Fully Functional HLA B27-Restricted CD4

The strong association of HLA B27 with spondyloarthropathies contrasts strikingly with most autoimmune diseases, which are HLA class II associated and thought to be mediated by CD4 (cid:1) T lymphocytes. By introducing a human-derived HLA B27-restricted TCR into HLA B27 transgenic mice, we have obtained a functional TCR transgenic model, GRb, dependent on HLA B27 for response. Surprisingly, HLA B27 supported CD4 (cid:1) as well as CD8 (cid:1) T cell responses in vivo and in vitro. Further, HLA B27-restriced CD4 (cid:1) T cells were capable of differentiation into a range of Th1 and Th2 T cell subsets with normal patterns of cytokine expression. The transgenic T cells were also able to enhance clearance of recombinant vaccinia virus containing inﬂuenza nucleoprotein in vivo. This is the ﬁrst description of a human HLA class I-restricted TCR transgenic line. The existence of CD4 (cid:1) MHC class I-restricted T cells has signiﬁcant implications for immune regulation in autoimmunity and, in particular, in HLA B27-associated arthritis. We believe that this model provides a novel system for the study of unusual T cell behavior in vivo. The Journal of Immunology, 2004, 172: 155–161.
Vibriocidal Antibody Responses to a Bivalent Killed Whole-Cell Oral Cholera Vaccine in a Phase III Trial in Kolkata, India

Background During the development of a vaccine, identification of the correlates of protection is of paramount importance for establishing an objective criterion for the protective performance of the vaccine. However, the ascertainment of correlates of immunity conferred by any vaccine is a difficult task. Methods While conducting a phase three double-blind, cluster-randomized, placebo-controlled trial of a bivalent killed whole-cell oral cholera vaccine in Kolkata, we evaluated the immunogenicity of the vaccine in a subset of participants. Randomly chosen participants (recipients of vaccine or placebo) were invited to provide blood samples at baseline, 14 days after the second dose and one year after the first dose. At these time points, serum geometric mean titers (GMT) of vibriocidal antibodies and seroconversion rates for vaccine and placebo arms were calculated and compared across the age strata (1 to 5 years, 5 to 15 years and more than 15 years) as well as for all age groups. Results Out of 137 subjects included in analysis, 69 were vaccinees and 68 received placebo. There were 5•7 and 5•8 geometric mean fold (GMF) rises in titers to Vibrio cholerae Inaba and Ogawa, respectively at 14 days after the second dose, with 57% and 61% of vaccinees showing a four-fold or greater titer rise, respectively. After one year, the titers to Inaba and Ogawa remained 1•7 and 2•8 fold higher, respectively, compared to baseline. Serum vibriocidal antibody response to V. cholerae O139 was much lower than that to Inaba or Ogawa. No significant differences in the GMF-rises were observed among the age groups. Conclusions The reformulated oral cholera vaccine induced a statistically significant anti-O1 Inaba and O1 Ogawa vibriocidal antibody response 14 days after vaccination, which although declined after one year remained significantly higher than baseline. Despite this decline, the vaccine remained protective five years after vaccination.