Miracle-dz/UniFAR-FTUs huggingface dataset:
Efficacy of flexible ureterorenoscopy with holmium laser in the management of stone-bearing caliceal diverticula.

PURPOSE We aim to evaluate the outcome of flexible ureterorenoscopy (F-URS) with a holmium laser in managing stone-bearing caliceal diverticula as a minimally invasive option. PATIENTS AND METHODS We retrospectively reviewed the records of 38 patients who underwent F-URS using a holmium laser from 2003 to 2009 for symptomatic stone-bearing caliceal diverticula. The presenting symptoms were renal colic, urinary tract infection, or hematuria. F-URS was used in 30 (78.9%) patients as an alternative after the failure of shockwave lithotropsy (SWL). F-URS was repeated twice for two patients. In the first patient, the indication was uncompleted fragmentation of the stone. In the second patient, it was because of failure to identify the diverticulum. The follow-up visit ranged from 4 to 6 weeks with plain radiography of the kidneys, ureters, and bladder and either renal ultrasonography or noncontrast CT. RESULTS Patients who were included in the study were 38: 22 women and 16 men (mean age 45.7 years; range 18-72 years). Post-F-URS, 21 (55.3%) patients were rendered stone free (SF), 10 (26.3%) patients had clinically insignificant residual fragments (less than 4 mm) (CIRF), and a residual fragment (RF) was found in seven (18.4%) patients. The success rate was considered as SF or CIRF, which was obtained in 31 (81.6%) patients. In total, 34 (90%) patients were symptom free after the procedure. CONCLUSION F-URS using a holmium laser is a very effective, minimally invasive technique. It could be the best option in managing stone-bearing caliceal diverticula, especially for those patients in whom there was SWL failure. The development of the actively deflectable ureteroscope with miniaturization allowed us to obtain a high success rate, low morbidity, and a brief hospital stay.
Selective Feticide in Twin Pregnancies with Very Early Preterm Premature Rupture of Membranes

Nine consecutive multichorionic multiple gestations with early second-trimester (< or =20 weeks) preterm premature rupture of the membranes (PPROM) of the lower gestational sac were managed expectantly. Mean gestational age at PPROM was 17.5 weeks (13-20 weeks), and the mean PPROM delivery time interval was 6.2 weeks (0-11 weeks). A fetal loss of 63% (12 of 19), and a subsequent neonatal loss of 57% (4 of 7) were observed. Of the four pregnancies evolving beyond 25 weeks, three delivered before 30 weeks. The baby take-home rate was 16% (3 of 19). Histologic evidence of chorioamnionitis was present in 5 of 7 (71%) investigated pregnancies. Three other consecutive twin pregnancies were complicated by PPROM of the precervical gestational sac at 13 to 16 weeks of gestation (mean: 15 weeks). In the absence of clinical chorioamnionitis and amniotic fluid, selective feticide with potassium chloride was performed. Pregnancy was successfully prolonged beyond 33 weeks in two cases. The overall PPROM delivery time interval was 21 weeks (20-22 weeks). No neonatal losses were encountered. The baby take-home rate was 66% (2 of 3). Selective feticide of the fetus with early midtrimester PROM in the absence of maternal signs of infection may improve the former unfavorable pregnancy outcome.
TSEB: More Efficient Thompson Sampling for Policy Learning

In model-based solution approaches to the problem of learning in an unknown environment, exploring to learn the model parameters takes a toll on the regret. The optimal performance with respect to regret or PAC bounds is achievable, if the algorithm exploits with respect to reward or explores with respect to the model parameters, respectively. In this paper, we propose TSEB, a Thompson Sampling based algorithm with adaptive exploration bonus that aims to solve the problem with tighter PAC guarantees, while being cautious on the regret as well. The proposed approach maintains distributions over the model parameters which are successively refined with more experience. At any given time, the agent solves a model sampled from this distribution, and the sampled reward distribution is skewed by an exploration bonus in order to generate more informative exploration. The policy by solving is then used for generating more experience that helps in updating the posterior over the model parameters. We provide a detailed analysis of the PAC guarantees, and convergence of the proposed approach. We show that our adaptive exploration bonus encourages the additional exploration required for better PAC bounds on the algorithm. We provide empirical analysis on two different simulated domains.
Delay-Based Network Utility Maximization

It is well known that max-weight policies based on a queue backlog index can be used to stabilize stochastic networks, and that similar stability results hold if a delay index is used. Using Lyapunov optimization, we extend this analysis to design a utility maximizing algorithm that uses explicit delay information from the head-of-line packet at each user. The resulting policy is shown to ensure deterministic worst-case delay guarantees and to yield a throughput utility that differs from the optimally fair value by an amount that is inversely proportional to the delay guarantee. Our results hold for a general class of 1-hop networks, including packet switches and multiuser wireless systems with time-varying reliability .
Modeling Spatial and Temporal Cues for Multi-label Facial Action Unit Detection

Facial action units (AUs) are essential to decode human facial expressions. Researchers have focused on training AU detectors with a variety of features and classifiers. However, several issues remain. These are spatial representation, temporal modeling, and AU correlation. Unlike most studies that tackle these issues separately, we propose a hybrid network architecture to jointly address them. Specifically, spatial representations are extracted by a Convolutional Neural Network (CNN), which, as analyzed in this paper, is able to reduce person-specific biases caused by hand-crafted features (eg, SIFT and Gabor). To model temporal dependencies, Long Short-Term Memory (LSTMs) are stacked on top of these representations, regardless of the lengths of input videos. The outputs of CNNs and LSTMs are further aggregated into a fusion network to produce per-frame predictions of 12 AUs. Our network naturally addresses the three issues, and leads to superior performance compared to existing methods that consider these issues independently. Extensive experiments were conducted on two large spontaneous datasets, GFT and BP4D, containing more than 400,000 frames coded with 12 AUs. On both datasets, we report significant improvement over a standard multi-label CNN and feature-based state-of-the-art. Finally, we provide visualization of the learned AU models, which, to our best knowledge, reveal how machines see facial AUs for the first time.
Feel, smell and see in an egg: emergence of perception and learning in an immature invertebrate, the cuttlefish embryo

SUMMARY It is now well established that prenatal sensory experience affects development itself and has long-term consequences in terms of postnatal behavior. This study focused on the functionality of the sensory system in cuttlefish in ovo. Embryos of stage 23, 25 and 30 received a tactile, chemical or visual stimulus. An increase of mantle contraction rhythm was taken to indicate a behavioral response to the stimulus. We clearly demonstrated that tactile and chemical systems are functional from stage 23, whereas the visual system is functional only from stage 25. At stage 25 and 30, embryos were also exposed to a repeated light stimulus. Stage 30 embryos were capable of habituation, showing a progressive decrease in contractions across stimulations. This process was not due to fatigue as we observed response recovery after a dishabituation tactile stimulus. This study is the first to show that cuttlefish embryos behaviorally respond to stimuli of different modalities and that the visual system is the last to become functional during embryonic development, as in vertebrate embryos. It also provides new evidence that the memory system develops in ovo in cuttlefish.
Topological M-theory as unification of form theories of gravity

We introduce a notion of topological M-theory and argue that it provides a unification of form theories of gravity in various dimensions. Its classical solutions involve G_2 holonomy metrics on 7-manifolds, obtained from a topological action for a 3-form gauge field introduced by Hitchin. We show that by reductions of this 7-dimensional theory, one can classically obtain 6-dimensional topological A and B models, the self-dual sector of loop quantum gravity in four dimensions, and Chern–Simons gravity in 3 dimensions. We also find that the 7-dimensional M-theory perspective sheds some light on the fact that the topological string partition function is a wavefunction, as well as on S-duality between the A and B models. The degrees of freedom of the A and B models appear as conjugate variables in the 7-dimensional theory. Finally, from the topological M-theory perspective, we find hints of an intriguing holographic link between non-supersymmetric Yang–Mills in four dimensions and A model topological strings on twistor space.
A Feasibility Study of Taste & See: A Church Based Programme to Develop a Healthy Relationship with Food

Holistic approaches which include a religious element are a promising intervention within obesity, but have not been explored in the UK. Objective: To conduct a feasibility study of a three-month, Christian-based intuitive-eating programme in a church. Methods: A total of 18 adults participated. Ethical approval was granted by Coventry University Ethics Committee. Participant and facilitator experience was investigated qualitatively. Results showed participants accepted the programme and engaged well with its spiritual component. Lay facilitators managed to adequately run the programme, although some difficulties identified training needs. Clinical, psychological and spiritual measures were analysed using intention to treat; baseline observation carried forward to input missing data. Mental well-being, anxiety, depression, quality of life, pain/discomfort uncontrolled-eating, emotional-eating, cognitive-restrained-eating, intuitive-eating and Body Mass Index (BMI) improved significantly post-intervention. There were improvements in spiritual well-being, and reductions in energy, fat and saturated fat intake. Between the end of the intervention and a six-month follow-up, there were no statistically significant changes. However, the extent that weight and BMI returned to baseline levels meant that the reduction from baseline was no longer significant or clinically important. Mean changes in other variables, including uncontrolled eating, emotional eating, mental well-being and anxiety remained statistically improved from baseline. At six-month follow-up, improvements in intuitive eating were fully sustained at this time point and total fat, saturated fat and sugar intake had reduced further even though these values did not reach statistical significance. Conclusion: It is feasible to recruit to, deliver and evaluate Taste & See in a UK church, with lay volunteers. Clinical outcomes were positive, but a larger, controlled study is needed.
Visual Attention to Words in Different Languages in Bilinguals: A Magnetoencephalographic Study

We recorded evoked magnetic fields from bilingual subjects while they were visually presented with words. The task was to count words in a target language when most of the words were in another language and there were also nontarget deviants in a third language. Our results indicate that in a multilingual visual environment there is a different need for attention to a nontarget language depending on whether the subject is attending to words in the subject's first (L1) or second (L2) language. When words in L2 are attended to, more effort appears to be devoted to words in the nontarget language than when words in L1 are attended to. In addition, attention to the nontarget language while counting words in L2 does not seem to depend on the age of acquisition of L2.
Osteoblast proliferation or differentiation is regulated by relative strengths of opposing signaling pathways

Skeletal development requires the correct balance of osteoblast proliferation, survival, and differentiation which is modulated by a network of signaling pathways and transcription factors. We have examined the role of the AKT (PKB), and ERK1/2 signaling pathways in the osteoblast response to FGFs, which inhibit differentiation, and to IGF‐1 and Wnt signaling, which promote it. Using osteoblastic cell lines as well as primary calvarial osteoblasts, we show that ERK1/2 and AKT have distinct effects in FGF‐induced osteoblast proliferation and differentiation. ERK1/2 is a primary mediator of FGF‐induced proliferation, but also contributes to osteoblast differentiation, while AKT is important for osteoblast survival. Signaling by IGF‐1, that promotes osteoblast differentiation, strongly activates AKT and weakly ERK1/2, while the opposite results are obtained with FGF, which inhibits differentiation. By introducing a constitutively active form of AKT, we found that increased AKT activity drives osteoblasts to differentiation. Increasing the AKT signal in osteoblasts that harbor FGFR2 activating mutations, found in Crouzon (342Y) and Apert (S22W) syndromes, is also able to drive differentiation in these cells, that normally fail to differentiate. Wnt signals, that promotes differentiation, also induce AKT phosphorylation, and cells expressing active AKT have increased levels of stabilized beta‐catenin, a central molecule in Wnt signaling. Our results indicate that the relative strengths of ERK and AKT signaling pathways determine whether osteoblasts are driven into proliferation or differentiation, and that the effects of AKT may be due, in part, to synergy with the Wnt pathway as well as with the Runx2 transcription factor. J. Cell. Physiol. 215: 442–451, 2008. © 2007 Wiley‐Liss, Inc.
HPV related diseases in males: a heavy vaccine-preventable burden

Summary Human Papillomavirus (HPV) has a significant impact in male's health, as cause of clinical manifestations ranging from genital warts to several cancers of the anogenital and aero-digestive tract. HPV types which most frequently affect men are 6,11,16 and 18, included in the HPV quadrivalent vaccine, recently approved for use in males by Food and Drug Administration (FDA) and European Medicines Agency (EMA). Although several data about the safety and efficacy of quadrivalent vaccine are available, the implementation of proper immunization plans dedicate to male's population cannot ignore the knowledge of the characteristics of the disease in men, which in some aspects should be clarify, in particular clearance of type-specific HPV infections and transmission dynamics. Purpose of this review is to summarise the main information about the burden and the natural history of the HPV related disease in males.
Curcumin inhibits cancer-associated fibroblast-driven prostate cancer invasion through MAOA/mTOR/HIF-1α signaling

Cancer-associated fibroblasts (CAFs) are key determinants in the malignant progression of cancer, supporting tumorigenesis and metastasis. CAFs also mediate epithelial to mesenchymal transition (EMT) in tumor cells and their achievement of stem cell traits. Curcumin has recently been found to possess anticancer activities via its effect on a variety of biological pathways involved in cancer progression. In this study, we found that CAFs could induce prostate cancer cell EMT and invasion through a monoamine oxidase A (MAOA)/mammalian target of rapamycin (mTOR)/hypoxia-inducible factor-1α (HIF-1α) signaling pathway, which exploits reactive oxygen species (ROS) to drive a migratory and aggressive phenotype of prostate carcinoma cells. Moreover, CAFs was able to increase CXC chemokine receptor 4 (CXCR4) and interleukin-6 (IL-6) receptor expression in prostate cancer cells. However, curcumin abrogated CAF-induced invasion and EMT, and inhibited ROS production and CXCR4 and IL-6 receptor expression in prostate cancer cells through inhibiting MAOA/mTOR/HIF-1α signaling, thereby supporting the therapeutic effect of curcumin in prostate cancer.
Deletion of a conserved regulatory element required for Hmx 1 expression in craniofacial mesenchyme in the dumbo rat : a novel cause of congenital ear malformation

Center for Integrative Brain Research, Seattle Children’s Research Institute, Seattle, WA Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University, Kyoto, Japan Center on Human Development and Disability, University of Washington, Seattle, WA Department of Pediatrics (Craniofacial Medicine), University of Washington, and Center for Tissue & Cell Sciences, Seattle Children’s Research Institute, Seattle, WA Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria,
Fate of pioneering vegetation patches in a dynamic meandering river

Fluvial biomorphodynamics in actively meandering rivers entail interactions between hydromorphodynamics and pioneering tree species that have eco‐engineering effects. Here we study spatiotemporal patterns of vegetation patches smaller than 150 m2 in a 4 km reach of the river Allier in France in order to unravel causes for tree persistence and mortality and identify spatial trends across the river valley. To this end we analysed aerial photographs by object‐based image analysis over a period of 56 years and tracked individual patches through time. Furthermore the cover and surface age of the study reach were classified. The large‐scale shifts of channels, bars and vegetation are consistent with the meandering process and chute cutoffs. However, the spatiotemporal patterns of the vegetation patches are surprising in that they are ubiquitous and have ages up to decades on the highly dynamic meander belt, but hardly expand into larger vegetation patches. Patches disappear exponentially as a function of their age, and faster so in the last decades. Causes are amalgamation into the riparian forest flanking the meander belt and mortality likely due to desiccation or erosion. Patches have a higher probability of survival when further away from the active channel and closer to high vegetation patches and valley boundary. The window of opportunity of vegetation settlement widens towards the valley boundaries and in floodplain lows of former channels and chutes. These results imply a gradual cross‐valley gradient of riparian vegetation settling, survival and succession. © 2019 The Authors. Earth Surface Processes and Landforms Published by John Wiley & Sons Ltd.
The LU-LC conjecture, diagonal local operations and quadratic forms over GF(2)

We report progress on the LU-LC conjecture--an open problem in the context of entanglement in stabilizer states (or graph states). This conjecture states that every two stabilizer states which are related by a local unitary operation, must also be related by a local operation within the Clifford group. The contribution of this paper is a reduction of the LU-LC conjecture to a simpler problem--which, however, remains to date unsolved. As our main result, we show that, if the LU-LC conjecture could be proved for the restricted case of diagonal local unitary operations, then the conjecture is correct in its totality. Furthermore, the reduced version of the problem, involving such diagonal local operations, is mapped to questions regarding quadratic forms over the finite field GF(2). Finally, we prove that correctness of the LU-LC conjecture for stabilizer states implies a similar result for the more general case of stabilizer codes.
ecision-Making Impairments in the Context of Intact eward Sensitivity in Schizophrenia

ackground: Deficits in motivated behavior and decision-making figure prominently in the behavioral syndrome that characterizes chizophrenia and are difficult both to treat and to understand. One explanation for these deficits is that schizophrenia decreases sensitivity o rewards in the environment. An alternate explanation is that sensitivity to rewards is intact but that poor integration of affective with ognitive information impairs the ability to use this information to guide behavior.
Changes in objectively measured smoking in pregnancy by time and legislative changes in Finland: a retrospective cohort study

Objectives To study the changes in prevalence, characteristics and outcomes of pregnant smokers over time and legislative changes. Design and setting Retrospective nationwide cohort. Participants Our study consisted of 9627 randomly selected pregnancies from the Finnish Maternity Cohort (1987–2011), with demographic characteristics and pregnancy and perinatal data obtained from the Medical Birth Registry and early pregnancy serum samples analysed for cotinine levels. Women were categorised based on their self-reported smoking status and measured cotinine levels (with ≥4.73 ng/mL deemed high). Data were stratified to three time periods based on legislative changes in the Tobacco Act. Primary and secondary outcome measures Prevalence of pregnant smokers and demographics, and perinatal and pregnancy outcomes of pregnant smokers over time. Results Overall, 71.6% of women were non-smokers, 16.2% were active cigarette smokers, 7.7% undisclosed smoking but had high cotinine levels and 4.5% were inactive cigarette smokers. The prevalence of active cigarette smokers decreased from mid-1990s onwards among women aged ≥30 years, probably due to the ban of cigarette smoking in most workplaces. We observed no changes in the prevalence of inactive smokers or women who undisclosed smoking by time or legislative changes. Women who undisclosed smoking had similar characteristics and perinatal outcomes as inactive and active smokers. Compared with non-smokers, women who undisclosed smoking were more likely to be young, unmarried, have a socioeconomic status lower than white-collar worker and have a preterm birth. Conclusions Women who undisclosed smoking were very similar to pregnant cigarette smokers. We observed a reduction in the prevalence of active pregnant cigarette smokers after the ban of indoor smoking in workplaces and restaurants, mostly among women aged ≥30 years.
Adaptive Voltage Scaling with In-Situ Detectors in Commercial FPGAs

This paper investigates the limits of adaptive voltage scaling (AVS) applied to commercial FPGAs which do not specifically support voltage adaptation. An adaptive power architecture based on a modified design flow is created with in-situ detectors and dynamic reconfiguration of clock management resources. AVS is a power-saving technique that enables a device to regulate its own voltage and frequency based on workload, process and operating conditions in a closed-loop configuration. It results in significant improved energy profiles compared with dynamic voltage frequency scaling (DVFS) in which the device uses a number of pre-calculated valid working points. The results of deploying AVS in FPGAs with in-situ detectors shows power and energy savings exceeding 85 percent compared with nominal voltage operation at the same frequency. The in-situ detector approach compares favorably with critical path replication based on delay lines since it avoids the need of cumbersome and error-prone delay line calibration.