Miracle-dz/UniFAR-FTUs huggingface dataset:
The Convergent Structure of DSM-5 Personality Trait Facets and Five-Factor Model Trait Domains

The DSM-5 Personality and Personality Disorder Work Group have proposed diagnosing personality disorder based in part on 25 pathological traits. Initial research suggests that five factors explain the covariance among these traits and that these factors reflect the domains of the well-validated Five-Factor Model (FFM) of normative personality. This finding is important because it signifies the potential to apply normative trait research to personality disorder classification in the DSM-5. In this study, trait scale scores on the Personality Inventory for DSM-5 (PID-5) and domain scores from the FFM Rating Form (FFMRF) were subjected to a conjoint exploratory factor analysis (EFA) to test the higher-order convergence of the DSM-5 pathological trait model and the FFM in a nonclinical sample (N = 808). Results indicate that the five higher-order factors of the conjoint EFA reflect the domains of the FFM. The authors briefly discuss implications of this correspondence between the normative FFM and the pathological PID-5.
Impact of Education Based on Theory of Planned Behavior: An Investigation into Hypertension-Preventive Self-care Behaviors in Iranian Girl Adolescent

Background: Since risk factors of hypertension are formed during adolescent period and regarding that attitudes change occurs more easily in these ages, the present paper aimed to evaluate the impact of education based on the theory of planned behavior in hypertension prevention behaviors in female adolescent students. Methods: In this quasi-experimental study, 160 girls of 12–16 yr old (80 in each case and control group), who had not been educated in prevention of hypertension over the recent three months, participated. Four schools in Tehran were selected based on cluster sampling method during two stages. The education was provided based on the theory of planned behavior in two sections (nutrition and physical activity) in four sessions. Data gathered before and after education through a two-part valid and reliable questionnaire. The results were analyzed based on SPSS software, version 17. Results: The results of independent t-test showed in the nutrition section, attitude (P=0.000), subjective norm (P=0.025), perceived control (P=0.016) and behavioral intention (P=0.025); significantly increased. About physical activity, except subjective norm (P=0.219), the mean score of the attitude (P=0.001), perceived control (P=0.000) and behavioral intention (P=0.000) revealed a significant difference between two groups. Conclusion: Education based on the theory of planned behavior affects the intention of preventive behaviors of hypertension in female adolescents.
A strong version of the redundancy-capacity theorem of universal coding

The capacity of the channel induced by a given class of sources is well known to be an attainable lower bound on the redundancy of universal codes with respect to this class, both in the minimax sense and in the Bayesian (maximin) sense. We show that this capacity is essentially a lower bound also in a stronger sense, that is, for "most" sources in the class. This result extends Rissanen's (1984, 1986) lower bound for parametric families. We demonstrate the applicability of this result in several examples, e.g., parametric families with growing dimensionality, piecewise-fixed sources, arbitrarily varying sources, and noisy samples of learnable functions. Finally, we discuss implications of our results to statistical inference. >
Weber's Law in Decision Making: Integrating Behavioral Data in Humans with a Neurophysiological Model

Recent single-cell studies in monkeys (Romo et al., 2004) show that the activity of neurons in the ventral premotor cortex covaries with the animal's decisions in a perceptual comparison task regarding the frequency of vibrotactile events. The firing rate response of these neurons was dependent only on the frequency differences between the two applied vibrations, the sign of that difference being the determining factor for correct task performance. We present a biophysically realistic neurodynamical model that can account for the most relevant characteristics of this decision-making-related neural activity. One of the nontrivial predictions of this model is that Weber's law will underlie the perceptual discrimination behavior. We confirmed this prediction in behavioral tests of vibrotactile discrimination in humans and propose a computational explanation of perceptual discrimination that accounts naturally for the emergence of Weber's law. We conclude that the neurodynamical mechanisms and computational principles underlying the decision-making processes in this perceptual discrimination task are consistent with a fluctuation-driven scenario in a multistable regime.
Nonperturbative sum over topologies in 2D Lorentzian quantum gravity

The recent progress in the Causal Dynamical Triangulations (CDT) approach to quantum gravity indicates that gravitation is nonperturbatively renormalizable. We review some of the latest results in 1+1 and 3+1 dimensions with special emphasis on the 1+1 model. In particular we discuss a nonperturbative implementation of the sum over topologies in the gravitational path integral in 1+1 dimensions. The dynamics of this model shows that the presence of infinitesimal wormholes leads to a decrease in the effective cosmological constant. Similar ideas have been considered in the past by Coleman and others in the formal setting of 4D Euclidean path integrals. A remarkable property of the model is that in the continuum limit we obtain a finite space‐time density of microscopic wormholes without assuming fundamental discreteness. This shows that one can in principle make sense out of a gravitational path integral including a sum over topologies, provided one imposes suitable kinematical restrictions on the state‐sp.
Spontaneous sequence duplications within capsule genes cap8E and tts control phase variation in Streptococcus pneumoniae serotypes 8 and 37.

Capsule phase variants were isolated from serotype 8 and serotype 37 pneumococcal sorbarods. Sequence duplications within the essential capsule genes - cap8E (type 8) and tts (type 37) - were found to introduce frameshifts and generate acapsular phenotypes. Capsular revertants possessed wild-type cap8E and tts genes, indicating the precise excision of these duplications. Reversion frequencies (OFF-ON) fit a linear relationship between log(frequency of reversion) and log(length of duplication), previously found for serotype three pneumococci [Waite, R. D. , Struthers, J. K. & Dowson, C. G. (2001). Mol Microbiol 42, 1223-1232]. This study provides evidence that capsule phase variation can occur in pneumococcal serotypes with either simple (one to three genes) or complex capsule-encoding loci (12 genes). Given the key role of CapE (the first monosaccharide transferase) in other clinically important pneumococci, such as serotypes 14 and 19F with complex capsular loci, the observed duplication within cap8E suggests that capsule phase variation could be controlled by tandem sequence duplication in capE homologues in other pneumococcal serotypes that construct their capsules through polymerization of lipid-linked intermediates.
Modeling Permafrost Response of the Last Glacial Termination: First Results of the VAMPER Model.

This paper introduces the VAMPER model, a 1-D numerical finite-difference permafrost model designed for eventual coupling with an earth system model of intermediate complexity (EMIC). The purpose of such coupling is to examine the relationship between permafrost and climate at millennial timescales with specific focus on possible feedback effects of a changing permafrost regime. First results here include 1) an equilibrium experiment where the VAMPER model simulated the current depth of permafrost at Barrow, Alaska; 2) validation of the VAMPER model by comparing results to two other previously published models; and 3) a deglaciation transient experiment done for Wyoming, USA, forced by surface temperatures from the EMIC LOVECLIM.
Expression of human telomerase reverse transcriptase in bone marrow CD34+ cells from patients with β‐thalassemia major

BACKGROUND: Normal stem cells usually express a low level of telomerase activity that serves to stabilize the chromosomes during cell division and helps prevent cell senescence. Human telomerase reverse transcriptase (hTERT) is a rate‐limiting enzyme that dictates the activity of human telomerase and thus decides the life span of cells. The expression of hTERT and its roles in β‐thalassemia major are unclear, however.
Identification of new, conserved, non‐ribosomal peptide synthetases from fluorescent pseudomonads involved in the biosynthesis of the siderophore pyoverdine

Pyoverdines, the main siderophores of fluorescent pseudomonads, contain a peptide moiety, different for each pyoverdine, and an identical chromophore. While it has been shown that non‐ribosomal peptide synthetases (NRPSs) are involved in the biosynthesis of the peptide chain of pyoverdines, this was not demonstrated for the biosynthesis of the chromo‐phore part. We found that PvsA, from Pseudomonas fluorescens ATCC 17400, and PvdL (PA2424), from Pseudomonas aeruginosa are similar NRPSs and functional homologues, necessary for the production of pyoverdine. Transcriptional lacZ fusions showed that pvdL is co‐transcribed with the upstream PA2425 gene, encoding a putative thioesterase, and is iron‐regulated via PvdS. Similarly, RT‐PCR analysis revealed that expression of pvsA is repressed by iron. Analysis of the adenylation domains of PvsA, PvdL and their homologues, revealed that their N‐terminus starts with an acyl‐CoA ligase module, followed by three amino acid activation domains. Computer modelling of these domains suggests that PvsA in P. fluorescens and PvdL in P. aeruginosa are orthologues involved in the biosynthesis of the pyoverdine chromophore.
Impact of Nucleoside Reverse Transcriptase Inhibitors on Mitochondria in Human Immunodeficiency Virus Type 1-Infected Children Receiving Highly Active Antiretroviral Therapy

ABSTRACT Mitochondrial toxicity induced by nucleoside reverse transcriptase inhibitors (NRTIs) has been reported to be responsible for various adverse effects. The relative impact of NRTIs on the mitochondria of human immunodeficiency virus (HIV) type 1 (HIV-1)-infected children receiving highly active antiretroviral therapy (HAART) is unknown. Mitochondrial DNA (mtDNA) levels were quantified longitudinally from peripheral blood mononuclear cells (PBMCs) in 31 HIV-1-infected children from Pediatric AIDS Clinical Trial Group Study 382 who were receiving HAART, including nelfinavir, efavirenz, and different NRTIs, and who had had undetectable plasma HIV-1 RNA levels for >2 years. The median mtDNA levels in PBMCs increased from 137 copies/cell at the baseline to 179 copies/cell at week 48 (P = 0.01) and 198 copies/cell at week 104 (P < 0.001). Before the initiation of HAART, children who received regimens containing didanosine had mtDNA levels persistently lower than those in children not receiving didanosine (106 versus 140 copies/cell; P = 0.008). During HAART, the median increase in the mtDNA level from the baseline to week 104 was the lowest in children who received regimens containing didanosine (+26 copies/cell) compared to those in children who received other regimens (+79 copies/cell) (P = 0.02). A multivariate analysis also demonstrated that didanosine, as part of HAART, was the only NRTI associated with the change in mtDNA levels (P = 0.007). Children receiving didanosine-containing antiretroviral regimens have the lowest mtDNA levels in PBMCs and may be at greater risk for long-term adverse effects due to mitochondrial toxicity. This may be of particular importance in resource-limited countries where didanosine is widely used for the treatment of HIV-infected children.
Hyperoxygenation Attenuated a Murine Model of Atopic Dermatitis through Raising Skin Level of ROS

Atopic dermatitis (AD) is a chronic inflammatory skin disease resulting from excessive stimulation of immune cells. Traditionally, reactive oxygen species (ROS) have been implicated in the progression of inflammatory diseases, but several opposing observations suggest the protective role of ROS in inflammatory disease. Recently, we demonstrated ROS prevented imiquimod-induced psoriatic dermatitis through enhancing regulatory T cell function. Thus, we hypothesized AD might also be attenuated in elevated levels of ROS through tissue hyperoxygenation, such as by hyperbaric oxygen therapy (HBOT) or applying an oxygen-carrying chemical, perfluorodecalin (PFD). Elevated levels of ROS in the skin have been demonstrated directly by staining with dihydroethidum as well as indirectly by immunohistochemistry (IHC) for indoleamine 2,3-dioxygenase (IDO). A murine model of AD was developed by repeated application of a chemical irritant (1% 2,4-dinitrochlorobenzene) and house dust mite (Dermatophagoide farinae) extract on one ear of BALB/c mice. The results showed treatment with HBOT or PFD significantly attenuated AD, comparably with 0.1% prednicarbate without any signs of side effects, such as telangiectasia. The expressions of interleukin-17A and interferon-γ were also decreased in the AD lesions by treatment with HBOT or PFD. Enhanced expression of IDO and reduced level of hypoxia-inducible factor-1α, in association with increased frequency of FoxP3+ regulatory T cells in the AD lesions, might be involved in the underlying mechanism of oxygen therapy. Taken together, it was suggested that tissue hyperoxygenation, by HBOT or treatment with PFD, might attenuate AD through enhancing skin ROS level.
Electrochemical gradients for Na+, K+, Cl– and H+ across the apical membrane in Malpighian (renal) tubule cells of Rhodnius prolixus

SUMMARY Measurements of intracellular and luminal ion activities as well as membrane potential were used to calculate electrochemical gradients for Cl–, Na+, K+ and H+ across the apical membrane during fluid secretion by Malpighian tubules of Rhodnius prolixus. The results show that the contribution of Na+/H+ and/or K+/H+ exchangers to fluid secretion is feasible both in unstimulated and serotonin-stimulated tubules. Similarly, the electrochemical potential for Cl– is consistent with the passive movement of Cl– from cell to lumen through Cl– channels. The contribution of apical K+:Cl– cotransport and/or paracellular Cl– movement to net transepithelial ion transport is thermodynamically unfeasible. pH in the lumen (pH 6.08±0.1, N=6) was more acid than in the bath (pH 7.25±0.01, N=26) and serotonin stimulation produced a significant increase in lumen pH to 6.32±0.04 (N=5). Intracellular pH was 6.97±0.01 and 6.82±0.04 in unstimulated and serotonin-stimulated tubules, respectively. Lumen pH was altered whereas intracellular pH was tightly regulated during serotonin and bumetanide treatment. Furthermore, DIDS or amiloride treatment did not affect intracellular pH. However, intracellular pH shifted 0.25 pH units more acid in Na+-free saline, suggesting that a Na+-dependent pH regulatory mechanism is at play in steady state pH regulation during fluid secretion by Malpighian tubules of Rhodnius prolixus. The data are consistent with a role for a basolateral Na+/H+ exchanger in intracellular pH regulation during fluid secretion.
The Addition of All-Trans Retinoic Acid to Chemotherapy May Not Improve the Outcome of Patient with NPM1 Mutated Acute Myeloid Leukemia

Background: Previous studies have suggested that NPM1 mutations may be a marker for response to all-trans retinoic acid (ATRA) given as an adjunct to intensive chemotherapy in older patients with acute myeloid leukemia (AML). Patients and Methods: We examined the impact of the addition of ATRA among patients with diploid cytogenetics treated on a randomized phase II study of fludarabine + cytarabine + idarubicine ± G-CSF ± ATRA with available data on their NPM1 mutation status. Between September 1995 and November 1997, 215 patients were enrolled in the study. Among them, 70 patients had diploid cytogenetic and are the subjects of this analysis. Results: The median age of the 70 patients was 66 years (range 23–87). Twenty (29%) of patients had NPM1 mutations. Among them 7 (35%) did and 13 (65%) did not receive ATRA in combination with chemotherapy. Complete remission (CR) was achieved in 71% of patients treated with ATRA as compared to 69% without ATRA (P = 0.62). With median follow-up of 12.5 years, the overall survival (OS), event-free survival (EFS), and relapse-free survival (RFS) were similar among patients who received ATRA compared to no ATRA regardless of NPM1 mutation status. Conclusion: The addition of ATRA to intensive chemotherapy did not affect the overall outcome of patients with AML regardless of NPM1 mutation status.
Evidence of dysfunction of endothelial progenitors in pulmonary arterial hypertension.

RATIONALE Severe pulmonary arterial hypertension (PAH) is characterized by the formation of plexiform lesions and concentric intimal fibrosis in small pulmonary arteries. The origin of cells contributing to these vascular lesions is uncertain. Endogenous endothelial progenitor cells are potential contributors to this process. OBJECTIVES To determine whether progenitors are involved in the pathobiology of PAH. METHODS We performed immunohistochemistry to determine the expression of progenitor cell markers (CD133 and c-Kit) and the major homing signal pathway stromal cell-derived factor-1 and its chemokine receptor (CXCR4) in lung tissue from patients with idiopathic PAH, familial PAH, and PAH associated with congenital heart disease. Two separate flow cytometric methods were employed to determine peripheral blood circulating numbers of angiogenic progenitors. Late-outgrowth progenitor cells were expanded ex vivo from the peripheral blood of patients with mutations in the gene encoding bone morphogenetic protein receptor type II (BMPRII), and functional assays of migration, proliferation, and angiogenesis were undertaken. measurements and main results: There was a striking up-regulation of progenitor cell markers in remodeled arteries from all patients with PAH, specifically in plexiform lesions. These lesions also displayed increased stromal cell-derived factor-1 expression. Circulating angiogenic progenitor numbers in patients with PAH were increased compared with control subjects and functional studies of late-outgrowth progenitor cells from patients with PAH with BMPRII mutations revealed a hyperproliferative phenotype with impaired ability to form vascular networks. CONCLUSIONS These findings provide evidence of the involvement of progenitor cells in the vascular remodeling associated with PAH. Dysfunction of circulating progenitors in PAH may contribute to this process.
Autologous bone marrow mononucleated cell preparation for the clinical treatment of acute myocardial infarction and peripheral arterial disease.

The concept that adult stem/progenitor cells can differentiate into either hematopoietic or nonhematopoietic tissues is supported by a considerable amount of reviewed data (1). Adult mononucleated cells (MNC) containing the stem/ progenitor cell fraction can be isolated from mobilized peripheral blood and bone marrow (BM) tissue by density gradients (2). BM MNC also contain mesenchymal stromal cells (MSC) (3), representing less than 0.1% of the density-gradient selected cells and capable of generating non-hematopoietic tissues (4,5). Endothelial progenitor cells (EPC), with their clonogenic potential, are major contributors to angiogenesis (6). As improved cardiac function depends on revascularization, local BM MNC delivery represents a strategy for supplying the reparative effects of EPC in injured hearts (7). Apart from myocardial and vascular regeneration as mechanisms of stem cell action, other models have been proposed where the transplanted cells could release soluble factors that, acting in a paracrine fashion, would contribute to cardiac repair and regeneration (8 – 10). Clinical applications and eligibility
Data Sharing and Scientific Impact in Eddy Covariance Research

Do the benefits of data sharing outweigh its perceived costs? This is a critical question, and one with the potential to change culture and behavior. Dai et al. (2018, https://doi.org/10.1002/2017JG004277) examined how data sharing is related to scientific impact in the field of eddy covariance (EC) and found that data sharers are disproportionately high‐impact researchers, and vice versa; they also note strong regional differences in EC data‐sharing norms. The current policies and restrictions of EC journals and repositories are highly uneven. Incentivizing data sharing and enhancing computational reproducibility are critical next steps for EC, ecology, and science more broadly.
Estimating the uncertainty in underresolved nonlinear dynamics

The Mori–Zwanzig formalism of statistical mechanics is used to estimate the uncertainty caused by underresolution in the solution of a nonlinear dynamical system. A general approach is outlined and applied to a simple example. The noise term that describes the uncertainty turns out to be neither Markovian nor Gaussian. It is argued that this is the general situation.
Changes in Hypothalamus–Pituitary–Adrenal Axis Following Transient Ischemic Attack

Acute brain ischemia caused by transient ischemic attack initiates a complex sequence of events in the central nervous system and hypothalamic–pituitary–adrenal (HPA) axis which may ultimately culminate in neuronal and cell damage. The brain is highly susceptible to ischemia and in response to stress shows changes in morphology and chemistry that are largely reversible. These responses are known to modify the function of the HPA axis, but their mechanisms are not yet clear. Duration and size of the HPA axis activation are regulated by corticotropin-releasing hormone, vasopressin (AVP), and glucocorticoids, including cortisol. Numerous studies suggest that activation of these hormones following brain ischemia can result in neurohormonal dysfunction that can exacerbate long-term prognosis following stroke. These studies represent evidence that changes in the HPA axis play an important role in brain ischemia.