Miracle-dz/UniFAR-FTUs huggingface dataset:
Needs Assessment Lessons Learned in Qatar: A Flipped Classroom Approach

This article was migrated. The article was marked as recommended. Continuing professional development (CPD) activities are expected to be purposeful and effective; the essential first step is a curriculum based on actual training needs. The Qatar Council for Healthcare Practitioners (QCHP) provides the oversight for accredited CPD programs for all groups of healthcare practitioners in Qatar this includes physicians, pharmacists, nurses and allied health professionals. In December 2017 several professionals created a local, collaborative and supportive network to share their expertise and to collaborate on accredited professional development initiatives. Network members included accredited CPD providers from two hospitals, Sidra Medicine and Aspetar, and from the College of the North Atlantic Qatar (CNA-Q). The implementation of a needs analysis is key to continuous service improvements. Network members conducted an audit of 43 educational programs in 2018 and found that this step is frequently missed or misinterpreted by curriculum planners. A workshop on needs assessments was seen as the most germane intervention to upskill program planners. An evidence-based approach was suggested in the development of a needs assessment teaching module. A review of the literature influenced the curriculum design as did a re-examination of adult learning principles and validated new methods to teaching in the health professions. The flipped classroom was identified as the most appropriate approach regarding design and content delivery. It requires skilled facilitators and content matter experts that are familiar with diverse teaching formats to ensure that learning outcomes are integrated across the formats. It has been documented that ‘flipping’ the classroom from a teacher-centered to a learner-centered approach encourages participants’ higher order learning and fosters engagement, exploration, evaluation and reflection.
Comparative Effect of Crude and Commercial Enzyme on the Juice Recovery from Bael Fruit (Aegle marmelos Correa) Using Principal Component Analysis

The effect of incubation time, incubation temperature, and crude enzyme concentration was observed on the yield, viscosity, and clarity of the juice obtained from bael fruit pulp. The recommended enzymatic treatment conditions from the study were incubation time 475 min, incubation temperature 45°C, and crude enzyme concentration 0.20 mL/25 g bael fruit pulp. The recovery, viscosity, and clarity of the juice under these conditions were 82.9%, 1.41 cps, and 21.32%T, respectively. The variables, clarity, and yield were found as principal components for comparing different samples of the juice treated with enzyme.
The Cognitive Process of Decision Making

Decision making is one of the basic cognitive processes of human behaviors by which a preferred option or a course of actions is chosen from among a set of alternatives based on certain criteria. Decision theories are widely applied in many disciplines encompassing cognitive informatics, computer science, management science, economics, sociology, psychology, political science, and statistics. A number of decision strategies have been proposed from different angles and applica-tion domains such as the maximum expected utility and Bayesian method. However, there is still a lack of a fundamental and mathematical decision model and a rigorous cognitive process for decision making. This article presents a fundamental cognitive decision making process and its mathematical model, which is described as a sequence of Cartesian-product based selections. A rigorous description of the decision process in real-time process algebra (RTPA) is provided. Real-world decisions are perceived as a repetitive application of the fundamental cognitive process. The result shows that all categories of decision strategies fit in the formally described decision process. The cognitive process of decision making may be applied in a wide range of decision-based systems such as cognitive informatics, software agent systems, expert systems, and decision support systems.
Feed-forward and visual feedback control of head roll orientation in wasps (Polistes humilis, Vespidae, Hymenoptera)

SUMMARY Flying insects keep their visual system horizontally aligned, suggesting that gaze stabilization is a crucial first step in flight control. Unlike flies, hymenopteran insects such as bees and wasps do not have halteres that provide fast, feed-forward angular rate information to stabilize head orientation in the presence of body rotations. We tested whether hymenopteran insects use inertial (mechanosensory) information to control head orientation from other sources, such as the wings, by applying periodic roll perturbations to male Polistes humilis wasps flying in tether under different visual conditions indoors and in natural outdoor conditions. We oscillated the thorax of the insects with frequency-modulated sinusoids (chirps) with frequencies increasing from 0.2 to 2 Hz at a maximal amplitude of 50 deg peak-to-peak and maximal angular velocity of ±245 deg s−1. We found that head roll stabilization is best outdoors, but completely absent in uniform visual conditions and in darkness. Step responses confirm that compensatory head roll movements are purely visually driven. Modelling step responses indicates that head roll stabilization is achieved by merging information on head angular velocity, presumably provided by motion-sensitive neurons and information on head orientation, presumably provided by light level integration across the compound eyes and/or ocelli (dorsal light response). Body roll in free flight reaches amplitudes of ±40 deg and angular velocities greater than 1000 deg s−1, while head orientation remains horizontal for most of the time to within ±10 deg. In free flight, we did not find a delay between spontaneous body roll and compensatory head movements, and suggest that this is evidence for the contribution of a feed-forward control to head stabilization.
Mammalian Rad9 Plays a Role in Telomere Stability, S- and G2-Phase-Specific Cell Survival, and Homologous Recombinational Repair

ABSTRACT The protein products of several rad checkpoint genes of Schizosaccharomyces pombe (rad1+, rad3 +, rad9 +, rad17 +, rad26 +, and hus1 +) play crucial roles in sensing changes in DNA structure, and several function in the maintenance of telomeres. When the mammalian homologue of S. pombe Rad9 was inactivated, increases in chromosome end-to-end associations and frequency of telomere loss were observed. This telomere instability correlated with enhanced S- and G2-phase-specific cell killing, delayed kinetics of γ-H2AX focus appearance and disappearance, and reduced chromosomal repair after ionizing radiation (IR) exposure, suggesting that Rad9 plays a role in cell cycle phase-specific DNA damage repair. Furthermore, mammalian Rad9 interacted with Rad51, and inactivation of mammalian Rad9 also resulted in decreased homologous recombinational (HR) repair, which occurs predominantly in the S and G2 phases of the cell cycle. Together, these findings provide evidence of roles for mammalian Rad9 in telomere stability and HR repair as a mechanism for promoting cell survival after IR exposure.
Discrepancies between self- and other-esteem as correlates of aggression

This research examines the opposing theories that high self–esteem is responsible for aggression and that low self–esteem is responsible for aggression. Our findings suggest that both theories may be correct. Targets’ self–esteem and self–reported physical aggression were assessed; additionally, targets’ roommates reported their esteem for the target. In support of both theories, self–esteem was related to aggression in a curvilinear fashion, such that very low and very high self–esteem people were more likely to report physical aggression than moderate self–esteem people. This phenomenon was partly qualified by interpersonal context; specifically, participants who thought more positively of themselves than their roommates thought of them as well as participants who thought less positively of themselves than their roommates thought of them reported higher levels of physical aggression. Those whose self–esteem (low or high) corresponded to roommates’ esteem of them did not report physical aggression. These findings inform psychological theories of aggression, especially regarding self–views and interpersonal reality.
The Saccharomyces cerevisiae Histone Chaperone Rtt106 Mediates the Cell Cycle Recruitment of SWI/SNF and RSC to the HIR-Dependent Histone Genes

Background In Saccharomyces cerevisiae, three out of the four histone gene pairs (HTA1-HTB1, HHT1-HHF1, and HHT2-HHF2) are regulated by the HIR co-repressor complex. The histone chaperone Rtt106 has recently been shown to be present at these histone gene loci throughout the cell cycle in a HIR- and Asf1-dependent manner and involved in their transcriptional repression. The SWI/SNF and RSC chromatin remodeling complexes are both recruited to the HIR-dependent histone genes; SWI/SNF is required for their activation in S phase, whereas RSC is implicated in their repression outside of S phase. Even though their presence at the histone genes is dependent on the HIR complex, their specific recruitment has not been well characterized. In this study we focused on characterizing the role played by the histone chaperone Rtt106 in the cell cycle-dependent recruitment of SWI/SNF and RSC complexes to the histone genes. Methodology/Principal Findings Using GST pull-down and co-immunoprecipitation assays, we showed that Rtt106 physically interacts with both the SWI/SNF and RSC complexes in vitro and in vivo. We then investigated the function of this interaction with respect to the recruitment of these complexes to HIR-dependent histone genes. Using chromatin immunoprecipitation assays (ChIP), we found that Rtt106 is important for the recruitment of both SWI/SNF and RSC complexes to the HIR-dependent histone genes. Furthermore, using synchronized cell cultures, we showed by ChIP assays that the Rtt106-dependent SWI/SNF recruitment to these histone gene loci is cell cycle regulated and restricted to late G1 phase just before the peak of histone gene expression in S phase. Conclusions/Significance Overall, these data strongly suggest that the interaction between the histone chaperone Rtt106 and both the SWI/SNF and RSC chromatin remodeling complexes is important for the cell cycle regulated recruitment of these two complexes to the HIR-dependent histone genes.
Security in Plan 9

The security architecture of the Plan 9 " operating system has recently been redesigned to address some technical shortcomings. This redesign provided an opportunity also to make the system more convenient to use securely. Plan 9 has thus improved in two ways not usually seen together: it has become more secure andeasier to use. The central component of the new architecture is a per-user self-contained agent called factotum. Factotum securely holds a copy of the user’s keys and negotiates authentication protocols, on behalf of the user, with secure services around the network. Concentrating security code in a single program offers several advantages including: ease of update or repair to broken security software and protocols; the ability to run secure services at a lower privilege level; uniform management of keys for all services; and an opportunity to provide single sign on, even to unchanged legacy applications.Factotum has an unusual architecture: it is implemented as a Plan 9 file server.
Accurate 3D head pose estimation under real-world driving conditions: A pilot study

Reliable and accurate car driver head pose estimation is an important function for the next generation of Advanced Driver Assistance Systems that need to consider the driver state in their analysis. For optimal performance, head pose estimation needs to be non-invasive, calibration-free and accurate for varying driving and illumination conditions. In this pilot study we investigate a 3D head pose estimation system that automatically fits a statistical 3D face model to measurements of a driver's face, acquired with a low-cost depth sensor on challenging real-world data. We evaluate the results of our sensor-independent, driver-adaptive approach to those of a state-of-the-art camera-based 2D face tracking system as well as a non-adaptive 3D model relative to own ground-truth data, and compare to other 3D benchmarks. We find large accuracy benefits of the adaptive 3D approach. Our system shows a median error of 5.99 mm for position and 2.12° for rotation while delivering a full 6-DOF pose with very little degradation from strong illumination changes or out-of-plane rotations of more than 50°. In terms of accuracy, 95% of all our results have a position error of less than 9.50 mm, and a rotation error of less than 4.41°. Compared to the 2D method, this represents a 59.7% reduction of the 95% rotation accuracy threshold, and a 56.1% reduction of the median rotation error.
Gaze beats mouse: A case study on a gaze-controlled breakout

We present an open-source, gaze-controlled adaptation of the well-known Breakout computer game. In a tournament where 20 subjects took turns playing this game against each other, one using gaze and one using a mouse, we demonstrate that gaze can be a superior input modality. In another experiment, we collected eye movement data from 9 subjects playing this game and find that expert and novice players differ in their employed eye movement strategies.
Patient radiation dose and protection from cone-beam computed tomography

After over one decade development, cone beam computed tomography (CBCT) has been widely accepted for clinical application in almost every field of dentistry. Meanwhile, the radiation dose of CBCT to patient has also caused broad concern. According to the literature, the effective radiation doses of CBCTs in nowadays market fall into a considerably wide range that is from 19 µSv to 1073 µSv and closely related to the imaging detector, field of view, and voxel sizes used for scanning. To deeply understand the potential risk from CBCT, this report also reviewed the effective doses from literatures on intra-oral radiograph, panoramic radiograph, lateral and posteroanterior cephalometric radiograph, multi-slice CT, and so on. The protection effect of thyroid collar and leaded glasses were also reviewed.
A Pilot Study on Intravesical Administration of Curcumin for Cystitis Glandularis

Cystitis glandularis (CG) is a proliferative disorder in the urinary bladder. The outcome of current treatments in some patients is not satisfactory. Curcumin, a herbal medicine that has been used for centuries, has shown great potential in treating various diseases. Our pilot study aimed to explore the feasibility of an intravesical treatment for CG using curcumin. 14 patients diagnosed with CG that remained symptomatic after primary treatments were enrolled, underwent a 3-month curcumin intravesical treatment (50 mg/50 mL, 1 hour, once per week for first 4 weeks and once per month for next 2 months) and were followed up for 3 months. Efficacy of the treatment was evaluated using core lower urinary tract symptom score (CLSS) questionnaire. 10 patients demonstrated persistent improvement in symptoms up to the end of the 6-month study. Their CLSS decreased significantly after the 3-month treatment (6.0 ± 0.8; P < 0.01) from the baseline (10.5 ± 1.6) and maintained decreasing till the end of the study (6.2 ± 0.7; P < 0.01). 4 patients were classified as nonresponders. Our study suggests the feasibility of further randomized controlled trials on curcumin intravesical treatment in CG patients who remain symptomatic after primary treatments.
Identifying opinion leaders in the blogosphere

Opinion leaders are those who bring in new information, ideas, and opinions, then disseminate them down to the masses, and thus influence the opinions and decisions of others by a fashion of word of mouth. Opinion leaders capture the most representative opinions in the social network, and consequently are important for understanding the massive and complex blogosphere. In this paper, we propose a novel algorithm called InfluenceRank to identify opinion leaders in the blogosphere. The InfluenceRank algorithm ranks blogs according to not only how important they are as compared to other blogs, but also how novel the information they can contribute to the network. Experimental results indicate that our proposed algorithm is effective in identifying influential opinion leaders.
The effect of building height variation on the multiple diffraction loss component of the Walnsch-Bertoni model

The Walfische model predicts the average path loss from a conceptualised model of the propagation environment in which propagation is assumed to take place over rows of buildings of equal height and spacing. The propagation loss is then separated from the free space wave-front spreading, multiple forward-diffraction past the rows of buildings and diffraction over the final rooftop down to the receiver. In this paper we use numerical simulations to examine the effect of random building height variations on the multiple diffraction loss component of the model. In particular, our results show that the average multiple diffraction loss component is increased by any building height variations. A simple equation, which agrees within 1 dB of the simulation results, is presented that relates building height variations, wavelength and average building separation to the increase in average multiple diffraction loss.
Prevalence of PALB2 Mutations in Breast Cancer Patients in Multi-Ethnic Asian Population in Malaysia and Singapore

Background The partner and localizer of breast cancer 2 (PALB2) is responsible for facilitating BRCA2-mediated DNA repair by serving as a bridging molecule, acting as the physical and functional link between the breast cancer 1 (BRCA1) and breast cancer 2 (BRCA2) proteins. Truncating mutations in the PALB2 gene are rare but are thought to be associated with increased risks of developing breast cancer in various populations. Methods We evaluated the contribution of PALB2 germline mutations in 122 Asian women with breast cancer, all of whom had significant family history of breast and other cancers. Further screening for nine PALB2 mutations was conducted in 874 Malaysian and 532 Singaporean breast cancer patients, and in 1342 unaffected Malaysian and 541 unaffected Singaporean women. Results By analyzing the entire coding region of PALB2, we found two novel truncating mutations and ten missense mutations in families tested negative for BRCA1/2-mutations. One additional novel truncating PALB2 mutation was identified in one patient through genotyping analysis. Our results indicate a low prevalence of deleterious PALB2 mutations and a specific mutation profile within the Malaysian and Singaporean populations.
FEMALE PREFERENCE FOR MALE COURTSHIP EFFORT CAN DRIVE THE EVOLUTION OF MALE MATE CHOICE

The evolution of male mate choice is constrained by costs of choice in species with a male‐biased operational sex ratio (OSR). Previous theoretical studies have shown that significant benefits of male choice are required, for example, by mating with more fecund females, in order for these costs to be offset and a male preference to spread. In a series of population genetic models we show the novel effect that male mating preference, expressed as a bias in courtship, can spread when females prefer, and thus are more likely to mate with, males who court more. We explore two female preference functions for levels of male courtship, one representing a threshold and the other a weighted female preference. The basic finding generally holds for both preference functions. However, the preference function greatly affects the spread of a male preference allele after the addition of competing males who can court more in total. Our results thus stress that a thorough understanding of the response of females to male courtship is a critical component to understanding male preference evolution in polygynous species.
Breaking Bad: Understanding Behavior of Crowd Workers in Categorization Microtasks

Crowdsourcing systems are being widely used to overcome several challenges that require human intervention. While there is an increase in the adoption of the crowdsourcing paradigm as a solution, there are no established guidelines or tangible recommendations for task design with respect to key parameters such as task length, monetary incentive and time required for task completion. In this paper, we propose the tuning of these parameters based on our findings from extensive experiments and analysis of categorization tasks. We delve into the behavior of workers that consume categorization tasks to determine measures that can make task design more effective.
Action of phosphorylated mannanoligosaccharides on immune and hematological responses and fecal consistency of dogs experimentally infected with enteropathogenic Escherichia coli strains

The therapeutic action of phosphorylated mannanoligosaccharides (MOS) was investigated regarding its prebiotic activity on enteropathogenic Escherichia coli (EPEC). Diarrhea was induced in dogs by experimental infection with EPEC strains. Then MOS was supplied once a day, in water for 20 days. Immunological (IgA and IgG), hematological (lymphocytes, neutrophils and monocytes) and bacteriological variables (PCR detection of the eae gene of EPEC recovered from stool culture), as well as occurrence of diarrhea were evaluated. All strains caused diarrhea at 24, 48 and 72 h after infection. PCR results indicated that E. coli isolated from stool culture of all infected animals had the eae gene. There was no significant difference among groups as to number of blood cells in the hemogram and IgA and IgG production. MOS was effective in recovering of EPEC-infected dogs since prebiotic-treated animals recovered more rapidly from infection than untreated ones (p < 0.05). This is an important finding since diarrhea causes intense dehydration and nutrient loss. The use of prebiotics for humans and other animals with diarrhea can be an alternative for the treatment and prophylaxis of EPEC infections.
A Multi-Domain Translation Model Framework for Statistical Machine Translation

While domain adaptation techniques for SMT have proven to be effective at improving translation quality, their practicality for a multi-domain environment is often limited because of the computational and human costs of developing and maintaining multiple systems adapted to different domains. We present an architecture that delays the computation of translation model features until decoding, allowing for the application of mixture-modeling techniques at decoding time. We also describe a method for unsupervised adaptation with development and test data from multiple domains. Experimental results on two language pairs demonstrate the effectiveness of both our translation model architecture and automatic clustering, with gains of up to 1 BLEU over unadapted systems and single-domain adaptation.
Multiplex Flow Cytometry Barcoding and Antibody Arrays Identify Surface Antigen Profiles of Primary and Metastatic Colon Cancer Cell Lines

Colon cancer is a deadly disease affecting millions of people worldwide. Current treatment challenges include management of disease burden as well as improvements in detection and targeting of tumor cells. To identify disease state-specific surface antigen signatures, we combined fluorescent cell barcoding with high-throughput flow cytometric profiling of primary and metastatic colon cancer lines (SW480, SW620, and HCT116). Our multiplexed technique offers improvements over conventional methods by permitting the simultaneous and rapid screening of cancer cells with reduced effort and cost. The method uses a protein-level analysis with commercially available antibodies on live cells with intact epitopes to detect potential tumor-specific targets that can be further investigated for their clinical utility. Multiplexed antibody arrays can easily be applied to other tumor types or pathologies for discovery-based approaches to target identification.