Miracle-dz/UniFAR-FTUs huggingface dataset:
Roles of Melatonin in Fetal Programming in Compromised Pregnancies

Compromised pregnancies such as those associated with gestational diabetes mellitus, intrauterine growth retardation, preeclampsia, maternal undernutrition, and maternal stress may negatively affect fetal development. Such pregnancies may induce oxidative stress to the fetus and alter fetal development through the epigenetic process that may affect development at a later stage. Melatonin is an oxidant scavenger that reverses oxidative stress during the prenatal period. Moreover, the role of melatonin in epigenetic modifications in the field of developmental programming has been studied extensively. Here, we describe the physiological function of melatonin in pregnancy and discuss the roles of melatonin in fetal programming in compromised pregnancies, focusing on its involvement in redox and epigenetic mechanisms.
The Analysis of First-Grade Teachers’ Need of Consultation in the First (FALL) Term of Academic Year

ABSTRACT This study aims at disclosing the consultation needs of first-grade teachers, who are responsible for orienting first-year pupils and teaching them how to read and write. There is a limited number of studies on the need for consultation of classroom teachers who must apply the main intervention techniques to achieve the necessary tasks during that period. Study data were collected from 7 first-grade teachers by means of semi-structured interviews that were conducted during the first semester of the 2015-2016 academic year. This study was designed according to a qualitative research model. The data were analyzed with qualitative content analysis. As a result, three main themes were derived, with 24 subthemesin different months of the semester. It was discovered that consultation needs of first-grade teachers differ by month. Consequently, it is recommended that these needs be considered in the context of future studies on consultation.
A qualitative investigation of the origins of excessive work behaviour

Studies of workers who engage in excessive work behaviour continue to attract the attention of researchers. Most research in this field adheres to quantitative methodologies aligned to the addiction or trait paradigms and largely focuses on correlates and consequences of such behaviour. However, within this literature, empirically based understandings of the factors that propel individuals to engage in excessive work patterns are sparse. Resting on socio-cultural theories of work, we adopt a novel approach to this field of enquiry and examine the genesis of excessive working using a qualitative methodology. We use discourse analysis to comparatively explore data from a sample of twenty-eight workers comprising excessive and non-excessive workers. Our study identified the roles of family of origin, educational experience, and professional norms as clear drivers of excessivework patterns. Data to support the dominant addiction and trait paradigms within this research domain were equivocal. Lifestyle decision-making differentiated the comparison group from the excessive workers. We discuss our findingswith reference to theories of workaholism and consider their implications for the evolution of this field.
On the Adaptive Significance of Circadian Clocks for Their Owners

Circadian rhythms are believed to be an evolutionary adaptation to daily environmental cycles resulting from Earth's rotation about its axis. A trait evolved through a process of natural selection is considered as adaptation; therefore, rigorous demonstration of adaptation requires evidence suggesting evolution of a trait by natural selection. Like any other adaptive trait, circadian rhythms are believed to be advantageous to living beings through some perceived function. Circadian rhythms are thought to confer advantage to their owners through scheduling of biological functions at appropriate time of daily environmental cycle (extrinsic advantage), coordination of internal physiology (intrinsic advantage), and through their role in responses to seasonal changes. So far, the adaptive value of circadian rhythms has been tested in several studies and evidence indeed suggests that they confer advantage to their owners. In this review, we have discussed the background for development of the framework currently used to test the hypothesis of adaptive significance of circadian rhythms. Critical examination of evidence reveals that there are several lacunae in our understanding of circadian rhythms as adaptation. Although it is well known that demonstrating a given trait as adaptation (or setting the necessary criteria) is not a trivial task, here we recommend some of the basic criteria and suggest the nature of evidence required to comprehensively understand circadian rhythms as adaptation. Thus, we hope to create some awareness that may benefit future studies in this direction. (Author correspondence: vsharma@jncasr.ac.in or vksharmas@gmail.com)
The patriotism down under: Nationalized qualities and Australian media consumption of the 2016 Rio Olympic Games

A survey of 291 Australians before and after consuming varied levels of Olympic media revealed key relationships between national identity, psychological connections to the Olympic Games, and media consumption of the Rio Games. The desire for nationalized emulation significantly predicted televisual media consumption; and the desire for nationalized identification and protection significantly predicted both print and digital media consumption. Differential motivations for identifying with Australia, fan involvement, and media consumption all yielded significant relationships with connection to the Olympics as a whole. Theoretical and applied implications are delineated.
Education and skills mismatch in the Italian graduate labour market

This paper focuses on education and skills mismatch among Italian graduates. Indicators for over- and under-utilization of education and under-utilization of skills are included as explanatory factors in a wage equation, testing theories that could explain the effect of over-schooling on wages. We find little evidence to support assignment theory and also identify a relatively weak wage effect arising from educational mismatch associated with employers’, as opposed to employees’, perceptions of the job requirements. Our interpretation is that some employers have re-categorized jobs as requiring a degree, when they were previously filled by non-graduates, and many have not altered pay scales accordingly.
Influence of ACTN3 R/X gene polymorphisms on racing strategy in rowing athletes

Abstract This study compared the polymorphisms RR, XX and RX of the ACTN3 gene among rowers with different race strategies across competitive levels and weight categories. We evaluated 137 rowers divided into: male non-elite openweight (n = 23), male elite openweight (n = 33), male non-elite lightweight (n = 31), male elite lightweight (n = 13), female non-elite openweight (n = 9), female elite openweight (n = 9) and female non-elite lightweight (n = 15), female elite lightweight (n = 4). The main results indicated that rowers who adopted starting/early (within the initial 500 m) or finishing/late (within the final 500 m) strategies exhibited similar ACTN3 genotype frequencies, while fewer athletes who adopted moderate (within the middle 1000 m) pacing strategies were categorised with the ACTN3 XX (8%) genotype as compared to the RR (50%) and RX (42%) genotypes (p = 0.002). Elite openweight male rowers with the ACTN3 RR more frequently preferred moderate pacing strategies (p = 0.006), while non-elite lightweight male athletes with ACTN3 RR more frequently preferred starting/early pacing strategies (p ≤ 0.001). Therefore, rowing athletes with specific ACTN3 genotypes may adopt unique race pacing strategies, while no differences were shown by competitive level or weight category.
A comparison of dynamic hand movements in chimpanzees (Pan troglodytes) and capuchin monkeys (Cebus apella)

TROGLODYTES) AND CAPUCHIN MONKEYS (CEBUS APELLA) by JESSICA L. CRAST (Under the Direction of Dorothy M. Fragaszy) ABSTRACT The ability to manipulate objects within the hand has been fully described in humans but remains to be documented and described in non-human primates. Studies suggest that several non-human primates are capable of such movements, evidenced by the dexterity of precision handling seen in the foraging and grooming behaviors of Old World primates and Cebus monkeys. Laboratory studies looking at individual control of the digits and neuroanatomy have supported this implication. This study presented a task to elicit in-hand movements in three adult chimpanzees (Pan troglodytes) and six adult capuchin monkeys (Cebus apella). All of the chimpanzees and two of the capuchins performed in-hand movements; the chimpanzees performed a wider variety of these movements and at a higher rate. The chimpanzees thus demonstrated more sophisticated control and coordination of the digits than the capuchins. The findings suggest behavioral consequences of the muscular, skeletal, and neuroanatomical features of each species.
The tetraspanin Tm4sf3 is localized to the ventral pancreas and regulates fusion of the dorsal and ventral pancreatic buds

During embryogenesis, the pancreas develops from separate dorsal and ventral buds, which fuse to form the mature pancreas. Little is known about the functional differences between these two buds or the relative contribution of cells derived from each region to the pancreas after fusion. To follow the fate of dorsal or ventral bud derived cells in the pancreas after fusion, we produced chimeric Elas-GFP transgenic/wild-type embryos in which either dorsal or ventral pancreatic bud cells expressed GFP. We found that ventral pancreatic cells migrate extensively into the dorsal pancreas after fusion, whereas the converse does not occur. Moreover, we found that annular pancreatic tissue is composed exclusively of ventral pancreas-derived cells. To identify ventral pancreas-specific genes that may play a role in pancreatic bud fusion, we isolated individual dorsal and ventral pancreatic buds, prior to fusion, from NF38/39 Xenopus laevis tadpoles and compared their gene expression profiles (NF refers to the specific stage of Xenopus development). As a result of this screen, we have identified several new ventral pancreas-specific genes, all of which are expressed in the same location within the ventral pancreas at the junction where the two ventral pancreatic buds fuse. Morpholino-mediated knockdown of one of these ventral-specific genes, transmembrane 4 superfamily member 3 (tm4sf3), inhibited dorsal-ventral pancreatic bud fusion, as well as acinar cell differentiation. Conversely, overexpression of tm4sf3 promoted development of annular pancreas. Our results are the first to define molecular and behavioral differences between the dorsal and ventral pancreas, and suggest an unexpected role for the ventral pancreas in pancreatic bud fusion.
Schema-conscious filtering of XML documents

In a publish-subscribe system based on filtering of XML documents, subscribers specify their interests with profiles expressed in the XPath language. The system processes a stream of XML documents and delivers to subscribers a notification or content of documents that match the profiles. For filtering with profiles expressed as linear XPath queries, automaton-based approaches exist where the intractable size growth of a preconstructed deterministic finite automaton is avoided by using a nondeterministic automaton. In this article we examine how these general approaches, which do not assume the existence of any specific schema or document type definition (DTD), might benefit from the knowledge that all the XML documents to be filtered obey a given DTD. We present an algorithm that utilizes the DTD in the preprocessing phase of the filtering automaton to prune out descendant operators (//) and wildcards (*) from the linear XPath filters. Experiments with data obtained from the XML Data Repository of the Univ. of Washington indicate that filter pruning can increase the throughput of the nondeterministic YFilter automaton by Diao et al. by a factor of 2 to 20. We also present a new filtering algorithm that is based on a backtracking deterministic finite automaton derived from the classic Aho--Corasick pattern-matching automaton. This automaton has a size linear in the sum of the sizes of the filters. For our algorithm, we obtained a throughput of 15 MB/sec for filters pruned from one million original filters (with all wildcards and non-leading descendant operators eliminated), representing an improvement by a factor of 2 to 3 upon the throughput of YFilter.
Cache-Centric Video Recommendation

In this article, we take advantage of the user behavior of requesting videos from the top of the related list provided by YouTube to improve the performance of YouTube caches. We recommend that local caches reorder the related lists associated with YouTube videos, presenting the cached content above noncached content. We argue that the likelihood that viewers select content from the top of the related list is higher than selection from the bottom, and pushing contents already in the cache to the top of the related list would increase the likelihood of choosing cached content. To verify that the position on the list really is the selection criterion more dominant than the content itself, we conduct a user study with 40 YouTube-using volunteers who were presented with random related lists in their everyday YouTube use. After confirming our assumption, we analyze the benefits of our approach by an investigation that is based on two traces collected from a university campus. Our analysis shows that the proposed reordering approach for related lists would lead to a 2 to 5 times increase in cache hit rate compared to an approach without reordering the related list. This increase in hit rate would lead to reduction in server load and backend bandwidth usage, which in turn reduces the latency in streaming the video requested by the viewer and has the potential to improve the overall performance of YouTube's content distribution system. An analysis of YouTube's recommendation system reveals that related lists are created from a small pool of videos, which increases the potential for caching content from related lists and reordering based on the content in the cache.
Large-Scale Isolation of Microsatellites from Chinese Mitten Crab Eriocheir sinensis via a Solexa Genomic Survey

Microsatellites are simple sequence repeats with a high degree of polymorphism in the genome; they are used as DNA markers in many molecular genetic studies. Using traditional methods such as the magnetic beads enrichment method, only a few microsatellite markers have been isolated from the Chinese mitten crab Eriocheir sinensis, as the crab genome sequence information is unavailable. Here, we have identified a large number of microsatellites from the Chinese mitten crab by taking advantage of Solexa genomic surveying. A total of 141,737 SSR (simple sequence repeats) motifs were identified via analysis of 883 Mb of the crab genomic DNA information, including mono-, di-, tri-, tetra-, penta- and hexa-nucleotide repeat motifs. The number of di-nucleotide repeat motifs was 82,979, making this the most abundant type of repeat motif (58.54%); the second most abundant were the tri-nucleotide repeats (42,657, 30.11%). Among di-nucleotide repeats, the most frequent repeats were AC motifs, accounting for 67.55% of the total number. AGG motifs were the most frequent (59.32%) of the tri-nucleotide motifs. A total of 15,125 microsatellite loci had a flanking sequence suitable for setting the primer of a polymerase chain reaction (PCR). To verify the identified SSRs, a subset of 100 primer pairs was randomly selected for PCR. Eighty two primer sets (82%) produced strong PCR products matching expected sizes, and 78% were polymorphic. In an analysis of 30 wild individuals from the Yangtze River with 20 primer sets, the number of alleles per locus ranged from 2–14 and the mean allelic richness was 7.4. No linkage disequilibrium was found between any pair of loci, indicating that the markers were independent. The Hardy-Weinberg equilibrium test showed significant deviation in four of the 20 microsatellite loci after sequential Bonferroni corrections. This method is cost- and time-effective in comparison to traditional approaches for the isolation of microsatellites.
GABAergic signaling in cortical feedback to the olfactory bulb

Cortical feedback conducts information towards earlier relays of information processing. It is instrumental for sensory perception. In the olfactory system, odorants are never experienced in isolation by the nose, and they might be meaningful to the animal or not depending on the context. Feedback inputs onto early processing stages are poised to permit selective attention to the relevant odorants in the olfactory scene. During my thesis work, I focused on understanding the key role that inhibitory GABAergic signaling plays in the cortical feedback to the olfactory bulb in mice.The first part of my work started with the discovery of excitatory transmission between cortical feedback inputs and the olfactory bulb is modulated by metabotropic receptors for GABA. Next, the impact of this regulation on the olfactory bulb network was investigated. We found that GABAergic signaling at cortical feedback axons profoundly changes the response of the olfactory bulb output cells to odor stimulation. In the second part of my thesis, I found that the cortical projections to the olfactory bulb not only comprises of excitatory components, but also inhibitory components. The precise origin of this GABAergic feedback was then determined and its impact on the olfactory bulb network is currently assessed. In particular, we observed that manipulating the activity of this GABAergic feedback perturbs olfactory behavior.
Platelet-derived interleukin 1 induces human endothelial adhesion molecule expression and cytokine production

Interleukin 1 (IL-1) plays a central role in the regulation of the body's response to infectious and inflammatory stimuli. Recent evidence has shown that human platelets express a cell associated form of this proinflammatory cytokine very rapidly following activation. Since one of the earliest events in inflammation is frequently the rapid adhesion of platelets to injured endothelium, it was of interest to determine whether platelets express IL-1 in a functionally relevant form that can alter the phenotype of human endothelial cells in vitro. Thrombin activated platelets induced significant expression of the adhesion molecule intercellular adhesion molecule 1, as well as secretion of the IL-1 inducible cytokines IL-6 and granulocyte macrophage colony stimulating factor by cultured human umbilical cord and saphenous vein endothelial cells. This was inhibited by prior treatment of the platelets with antibody specific for IL-1. These results suggest that platelet delivered IL-1 might initiate and regulate some of the earliest phases of the inflammatory response. An additional observation of interest was differential induction of endothelial leucocyte adhesion molecule 1 by activated platelets on saphenous vein but not umbilical vein but not umbilical vein endothelial cells, which suggests functional heterogeneity of the endothelial cells.
Comparison of Productivity of Colonies of Honey Bees, Apis mellifera, Supplemented with Sucrose or High Fructose Corn Syrup

Abstract Honey bee colony feeding trials were conducted to determine whether differential effects of carbohydrate feeding (sucrose syrup (SS) vs. high fructose corn syrup, or HFCS) could be measured between colonies fed exclusively on these syrups. In one experiment, there was a significant difference in mean wax production between the treatment groups and a significant interaction between time and treatment for the colonies confined in a flight arena. On average, the colonies supplied with SS built 7916.7 cm2 ± 1015.25 cm2 honeycomb, while the colonies supplied with HFCS built 4571.63 cm2 ± 786.45 cm2. The mean mass of bees supplied with HFCS was 4.65 kg (± 0.97 kg), while those supplied with sucrose had a mean of 8.27 kg (± 1.26). There was no significant difference between treatment groups in terms of brood rearing. Differences in brood production were complicated due to possible nutritional deficiencies experienced by both treatment groups. In the second experiment, colonies supplemented with SS through the winter months at a remote field site exhibited increased spring brood production when compared to colonies fed with HFCS. The differences in adult bee populations were significant, having an overall average of 10.0 ± 1.3 frames of bees fed the sucrose syrup between November 2008 and April 2009, compared to 7.5 ± 1.6 frames of bees fed exclusively on HFCS. For commercial queen beekeepers, feeding the right supplementary carbohydrates could be especially important, given the findings of this study.
The Influence of Knowledge, Islamic Religiosity and Self-Efficacy on the Intention to Pay Income Zakat among Public Educators in Kedah, Malaysia

Zakat is not only a religious obligation which must be complied by all eligible Muslims but also plays a very important role in Islamic fiscal system, specifically as a major source of income and could be used as an instrument to finance certain programs in order to achieve social, political and economic development among Muslim communities. However, the issue which arises is that zakat collection including income zakat is still low which hinders the effectiveness of zakat in playing a more significant role in the state of Kedah. Therefore, this study examines determinants of compliance behavior of income zakat by adding Islamic religiosity and moral obligation to the Theory of Planned Behavior (TPB) in order to gain more understanding of determinants of employment income zakat. The sample size used in this study is 372. This study uses PLS-SEM bootstrap and blindfolding technique in order to examine the relationship, effect size and predictive relevance of the variables of the study. This study proves that attitude, selfefficacy, moral obligation and religiosity have significant relationships and positive influence on intention. However, it is revealed there is no significant relationship between subjective norms, knowledge, perception towards promotional exposure, perception towards law, perception towards service quality, and perception towards equity in zakat distribution, tax rebate, and intention. Furthermore, the finding of this study demonstrates that Islamic religiosity plays a significant role in moderating the relationships between (i) moral obligation and intention and (ii) promotion and intention. Moreover, this study verifies that intention not only has a significant relationship but also significant and large effect size and large predictive relevance on compliance behavior. The findings of this study have important implications not only for knowledge but also to zakat institutions. The empirical evidence has important implications for theory as well as policy. Using a new method, PLS-SEM, this study is able to provide empirical evidence which is in line with findings of previous studies as well as new findings which expand the boundary of knowledge in the area of compliance behavior of zakat. The important contribution of this study is that the factors identified as significant determinants of compliance behavior of income zakat such as attitude, self-efficacy, moral obligation and Islamic religiosity could be useful as a guide for relevant authorities and policy makers to formulate suitable strategies to increase zakat collection in the future.