Miracle-dz/UniFAR-FTUs huggingface dataset:
Neural and sympathetic activity associated with exploration in decision-making: further evidence for involvement of insula

We previously reported that sympathetic activity was associated with exploration in decision-making indexed by entropy, which is a concept in information theory and indexes randomness of choices or the degree of deviation from sticking to recent experiences of gains and losses, and that activation of the anterior insula mediated this association. The current study aims to replicate and to expand these findings in a situation where contingency between options and outcomes is manipulated. Sixteen participants performed a stochastic decision-making task in which we manipulated a condition with low uncertainty of gain/loss (contingent-reward condition) and a condition with high uncertainty of gain/loss (random-reward condition). Regional cerebral blood flow was measured by 15O-water positron emission tomography (PET), and cardiovascular parameters and catecholamine in the peripheral blood were measured, during the task. In the contingent-reward condition, norepinephrine as an index of sympathetic activity was positively correlated with entropy indicating exploration in decision-making. Norepinephrine was negatively correlated with neural activity in the right posterior insula, rostral anterior cingulate cortex, and dorsal pons, suggesting neural bases for detecting changes of bodily states. Furthermore, right anterior insular activity was negatively correlated with entropy, suggesting influences on exploration in decision-making. By contrast, in the random-reward condition, entropy correlated with activity in the dorsolateral prefrontal and parietal cortices but not with sympathetic activity. These findings suggest that influences of sympathetic activity on exploration in decision-making and its underlying neural mechanisms might be dependent on the degree of uncertainty of situations.
Impact of doxorubicin dose capping on the outcome of DLBCL patients with elevated body surface area.

To the editor: In 2012, the American Society of Clinical Oncology (ASCO) published guidelines regarding the dosing of chemotherapy for obese patients with cancer. [1][1] In these patients, empiric dose reductions are often performed, usually by capping body surface area (BSA) at 2 m2 because of
Cardiac resynchronization therapy: a meta-analysis of randomized controlled trials

Background Studies of cardiac resynchronization therapy in addition to an implantable cardioverter defibrillator in patients with mild to moderate congestive heart failure had not been shown to reduce mortality until the recent RAFT trial (Resynchronization/Defibrillation for Ambulatory Heart Failure Trial). We performed a meta-analysis including the RAFT trial to determine the effect of cardiac resynchronization therapy with or without an implantable defibrillator on mortality. Methods We searched electronic databases and other sources for reports of randomized trials using a parallel or crossover design. We included studies involving patients with heart failure receiving optimal medical therapy that compared cardiac resynchronization therapy with optimal medical therapy alone, or cardiac resynchronization therapy plus an implantable defibrillator with a standard implantable defibrillator. The primary outcome was mortality. The optimum information size was considered to assess the minimum amount of information required in the literature to reach reliable conclusions about cardiac resynchronization therapy. Results Of 3071 reports identified, 12 studies (n = 7538) were included in our meta-analysis. Compared with optimal medical therapy alone, cardiac resynchronization therapy plus optimal medical therapy significantly reduced mortality (relative risk [RR] 0.73, 95% confidence interval [CI] 0.62–0.85). Compared with an implantable defibrillator alone, cardiac resynchronization therapy plus an implantable defibrillator significantly reduced mortality (RR 0.83, 95% CI 0.72–0.96). This last finding remained significant among patients with New York Heart Association (NYHA) class I or II disease (RR 0.80, 95% CI 0.67–0.96) but not among those with class III or IV disease (RR 0.84, 95% CI 0.69–1.07). Analysis of the optimum information size showed that the sequential monitoring boundary was crossed, which suggests no need for further clinical trials. Interpretation The cumulative evidence is now conclusive that the addition of cardiac resynchronization to optimal medical therapy or defibrillator therapy significantly reduces mortality among patients with heart failure.
Terra Incognita: On the Practicality of User-Space File Systems

To speed up development and increase reliability the Microkernel approach advocated moving many OS services to user space. At that time, the main disadvantage of microkernels turned out to be their poor performance. In the last two decades, however, CPU and RAM technologies have improved significantly and researchers demonstrated that by carefully designing and implementing a microkernel its overhead can be reduced significantly. Storage devices often remain a major bottleneck in systems due to their relatively slow speed. Thus, user-space I/O services, such as file systems and block layer, might see significantly lower relative overhead than any other OS services. In this paper we examine the reality of a partial return of the microkernel architecture--but for I/O subsystems only. We observed over 100 user-space file systems have been developed in recent years. However, performance analysis and careful design of user-space file systems were disproportionately overlooked by the storage community. Through extensive benchmarks we present Linux FUSE performance for several systems and 45 workloads. We establish that in many setups, FUSE already achieves acceptable performance but further research is needed for file systems to comfortably migrate to user space.
Selective Loss of Smaller Spines in Schizophrenia.

OBJECTIVE Decreased density of dendritic spines in adult schizophrenia subjects has been hypothesized to result from increased pruning of excess synapses in adolescence. In vivo imaging studies have confirmed that synaptic pruning is largely driven by the loss of large or mature synapses. Thus, increased pruning throughout adolescence would likely result in a deficit of large spines in adulthood. Here, the authors examined the density and volume of dendritic spines in deep layer 3 of the auditory cortex of 20 schizophrenia and 20 matched comparison subjects as well as aberrant voltage-gated calcium channel subunit protein expression linked to spine loss. METHOD Primary auditory cortex deep layer 3 spine density and volume was assessed in 20 pairs of schizophrenia and matched comparison subjects in an initial and replication cohort (12 and eight pairs) by immunohistochemistry-confocal microscopy. Targeted mass spectrometry was used to quantify postsynaptic density and voltage-gated calcium channel protein expression. The effect of increased voltage-gated calcium channel subunit protein expression on spine density and volume was assessed in primary rat neuronal culture. RESULTS Only the smallest spines are lost in deep layer 3 of the primary auditory cortex in subjects with schizophrenia, while larger spines are retained. Levels of the tryptic peptide ALFDFLK, found in the schizophrenia risk gene CACNB4, are inversely correlated with the density of smaller, but not larger, spines in schizophrenia subjects. Consistent with this observation, CACNB4 overexpression resulted in a lower density of smaller spines in primary neuronal cultures. CONCLUSIONS These findings require a rethinking of the overpruning hypothesis, demonstrate a link between small spine loss and a schizophrenia risk gene, and should spur more in-depth investigations of the mechanisms that govern new or small spine generation and stabilization under normal conditions as well as how this process is impaired in schizophrenia.
Role of Escherichia coli P fimbriae in intestinal colonization in gnotobiotic rats

Adherence via P fimbriae is associated with long-term persistence of Escherichia coli in the human large intestine, but a causal relationship has not been proven. In the present study, germfree rats were colonized with a mixture of two isogenic E. coli strains, one P fimbriated and the other type 1 fimbriated. Both types of fimbriae conferred adherence to rat colonic epithelial cells. With two mutant strains from a pyelonephritogenic isolate of serotype O75:K5:H-, the P-fimbriated strain 824 attained much higher numbers than its type 1-fimbriated counterpart when colonized in vivo for 2 weeks (10(10) versus 10(6) bacteria per g, respectively; P < 0.0001). The expression of P fimbriae by 824 was also retained during colonization. With transformant isogenic strains obtained from a normal fecal isolate incapable of phase variation, no benefit of P fimbriae was seen and most bacteria lost their plasmids during in vivo colonization. When the pyelonephritogenic mutant and fecal transformant strains were combined, the former colonized at high levels while the latter were suppressed. In contrast, no suppression was seen when the transformant E. coli strains colonized in combination with Lactobacillus acidophilus or Peptostreptococcus sp. The results indicate that P fimbriae, but also other bacterial traits linked to uropathogeneicity, could play an important role for persistence in the gut normal microbiota. Neither P nor type 1 fimbriae seemed to contribute to the ability to translocate to the mesenteric lymph nodes.
Increasing minority carrier lifetime in as-grown multicrystalline silicon by low temperature internal gettering

We report a systematic study into the effects of long low temperature (≤500 °C) annealing on the lifetime and interstitial iron distributions in as-grown multicrystalline silicon (mc-Si) from different ingot height positions. Samples are characterised in terms of dislocation density, and lifetime and interstitial iron concentration measurements are made at every stage using a temporary room temperature iodine-ethanol surface passivation scheme. Our measurement procedure allows these properties to be monitored during processing in a pseudo in situ way. Sufficient annealing at 300 °C and 400 °C increases lifetime in all cases studied, and annealing at 500 °C was only found to improve relatively poor wafers from the top and bottom of the block. We demonstrate that lifetime in poor as-grown wafers can be improved substantially by a low cost process in the absence of any bulk passivation which might result from a dielectric surface film. Substantial improvements are found in bottom wafers, for which annealing at 400 °C for 35 h increases lifetime from 5.5 μs to 38.7 μs. The lifetime of top wafers is improved from 12.1 μs to 23.8 μs under the same conditions. A correlation between interstitial iron concentration reduction and lifetime improvement is found in these cases. Surprisingly, although the interstitial iron concentration exceeds the expected solubility values, low temperature annealing seems to result in an initial increase in interstitial iron concentration, and any subsequent decay is a complex process driven not only by diffusion of interstitial iron.
Arrakis

Recent device hardware trends enable a new approach to the design of network server operating systems. In a traditional operating system, the kernel mediates access to device hardware by server applications to enforce process isolation as well as network and disk security. We have designed and implemented a new operating system, Arrakis, that splits the traditional role of the kernel in two. Applications have direct access to virtualized I/O devices, allowing most I/O operations to skip the kernel entirely, while the kernel is re-engineered to provide network and disk protection without kernel mediation of every operation. We describe the hardware and software changes needed to take advantage of this new abstraction, and we illustrate its power by showing improvements of 2 to 5 × in latency and 9 × throughput for a popular persistent NoSQL store relative to a well-tuned Linux implementation.
Low temperature reactions of thin layers of Mn with Si

Reactions between manganese thin films and silicon substrates, annealed at relatively low temperatures (<430 °C), have been systematically investigated. Three phases, i.e., Mn_3Si, Mn_5Si_3, and MnSi, were formed through a layered growth process. The formation sequence for these silicides was Mn_3Si, MnSi, and then Mn_5Si_3. The unusual phenomena of coexistence of these three phases and simultaneous growth of two phases (MnSi and Mn_5Si_3) were also observed. A model has been proposed to explain the growth behavior. The formation sequence of Mn_3Si, MnSi, and then Mn_5Si_3, and simultaneous growth of MnSi and Mn_5Si_3, can be explained by considering both thermodynamic and kinetic effects. Only those reactions that are thermodynamically allowed and kinetically preferred can take place. Kinetic preference is determined by the composition in the reaction region, which is controlled by the diffusion flux of the moving reactant. The proposed model is also compared with existing models.
Resolving multiple host use of an emergent pest of cotton with microsatellite data and chloroplast markers (Creontiades dilutus Stål; Hemiptera, Miridae)

Abstract Following the global uptake of transgenic cotton several Hemipteran pests have emerged as primary targets for pesticide control. Previous research on one such emergent pest: the green mirid, Creontiades dilutus, indicated differential use of two crop hosts, cotton (Gossypium hirsutum, Malvaceae) and lucerne (alfalfa) (Medicago sativa, Fabaceae). We tested the hypothesis that this apparent demographic independence of lucerne and cotton inhabiting mirids is the result of cryptic species being associated with these two crops. We assessed gene flow using microsatellite markers across adjacent cotton and lucerne crops at three geographically separated sites (up to 900 km apart). We also analysed the recent feeding behaviour of these insects by amplifying chloroplast markers from their gut contents. We find high gene flow between these two crops (mean pair wise FST between host plants=0.0141 within localities), and no evidence of cryptic species. Furthermore, the gut analyses revealed evidence of substantial recent movement between these two crops. We discuss the implications of these results for interpreting multiple host use in this species and setting future research priorities for this economically important pest.
Correction: Dose-Dependent ATP Depletion and Cancer Cell Death following Calcium Electroporation, Relative Effect of Calcium Concentration and Electric Field Strength

Electroporation, a method for increasing the permeability of membranes to ions and small molecules, is used in the clinic with chemotherapeutic drugs for cancer treatment (electrochemotherapy). Electroporation with calcium causes ATP (adenosine triphosphate) depletion and cancer cell death and could be a novel cancer treatment. This study aims at understanding the relationship between applied electric field, calcium concentration, ATP depletion and efficacy.
THOR: The H I, OH, Recombination line survey of the Milky Way. The pilot study: H I observations of the giant molecular cloud W43

To study the atomic, molecular, and ionized emission of giant molecular clouds (GMCs) in the Milky Way, we initiated a large program with the Karl G. Jansky Very Large Array (VLA): “THOR: The H i, OH, Recombination line survey of the Milky Way”. We map the 21 cm H i line, 4 OH lines, up to 19 Hα recombination lines and thecontinuum from 1 to 2 GHz of a significant fraction of the Milky Way (l = 15°−67°, | b | ≤ 1°) at an angular resolution of ~ 20″. Starting in 2012, as a pilot study we mapped 4 square degrees of the GMC associated with the W43 star formation complex. The rest of the THOR survey area was observed during 2013 and 2014. In this paper, we focus on the H i emission from the W43 GMC complex. Classically, the H i 21 cm line is treated as optically thin with properties such as the column density calculated under this assumption. This approach might yield reasonable results for regions of low-mass star formation, however, it is not sufficient to describe GMCs. We analyzed strong continuum sources to measure the optical depth along the line of sight, and thus correct the H i 21 cm emission for optical depth effects and weak diffuse continuum emission. Hence, we are able to measure the H i mass of this region more accurately and our analysis reveals a lower limit for the H i mass of M = 6.6-1.8 × 106 M⊙ (vLSR = 60−120 km s-1), which is a factor of 2.4 larger than the mass estimated with the assumption of optically thin emission. The H i column densities are as high as NH i ~ 150 M⊙ pc-2 ≈ 1.9 × 1022 cm-2, which is an order of magnitude higher than for low-mass star formation regions. This result challenges theoretical models that predict a threshold for the H i column density of ~10 M⊙ pc-2, at which the formation of molecular hydrogen should set in. By assuming an elliptical layered structure for W43, we estimate the particle density profile. For the atomic gas particle density, we find a linear decrease toward the center of W43 with values decreasing from nH i = 20 cm-3 near the cloud edge to almost 0 cm-3 at its center. On the other hand, the molecular hydrogen, traced via dust observations with the Herschel Space Observatory, shows an exponential increase toward the center with densities increasing to nH2> 200 cm-3, averaged over a region of ~10 pc. While atomic and molecular hydrogen are well mixed at the cloud edge, the center of the cloud is strongly dominated by H2 emission. We do not identify a sharp transition between hydrogen in atomic and molecular form. Our results, which challenge current theoretical models, are an important characterization of the atomic to molecular hydrogen transition in an extreme environment.
Localized SCF and IGF-1 secretion enhances erythropoiesis in the spleen of murine embryos

Fetal spleen is a major hematopoietic site prior to initiation of bone marrow hematopoiesis. Morphologic analysis suggested erythropoietic activity in fetal spleen, but it remained unclear how erythropoiesis was regulated. To address this question, we performed flow cytometric analysis and observed that the number of spleen erythroid cells increased 18.6-fold from 16.5 to 19.5 days post-coitum (dpc). Among erythropoietic cytokines, SCF and IGF-1 were primarily expressed in hematopoietic, endothelial and mesenchymal-like fetal spleen cells. Cultures treated with SCF and/or IGF-1R inhibitors showed significantly decreased CD45−c-Kit−CD71+/−Ter119+ erythroid cells and downregulated Gata1, Klf1 and &bgr;-major globin expression. Administration of these inhibitors to pregnant mice significantly decreased the number of CD45−c-Kit−CD71+/−Ter119+ cells and downregulated &bgr;-major globin gene expression in embryos derived from these mice. We conclude that fetal spleen is a major erythropoietic site where endothelial and mesenchymal-like cells primarily accelerate erythropoietic activity through SCF and IGF-1 secretion.
Effects of Propranolol on Bone Metabolism in Spontaneously Hypertensive Rats

The effects of propranolol (PRO), a nonselective β-adrenergic receptor (β-AR) antagonist with membrane-stabilizing action on bone metabolism, were examined in spontaneously hypertensive rats (SHR) showing osteoporosis with hyperactivity of the sympathetic nervous system. Treatment of SHR with PRO at 1 and 5 mg/kg p.o. for 12 weeks increased bone mass of the lumbar vertebra and proximal tibia without affecting blood pressure, but PRO at 50 and 100 mg/kg with hypotensive action did not increase bone mass. Next, the effects of PRO at 0.1, 1, and 10 mg/kg on bone status were examined in more detail. Compared with the SHR control, not only bone mass but also biomechanical parameters of strength and toughness of the lumbar vertebrae were increased in SHR treated with PRO at 0.1 and 1 mg/kg, suggesting antiosteoporotic action. PRO at 1 mg/kg statistically increased histomorphometry indices of bone formation, whereas PRO at doses of 0.1, 1, and 10 mg/kg decreased those of bone resorption. Antiosteoporotic effect of PRO is attenuated at 10 mg/kg compared with 0.1 and 1 mg/kg. In addition, treatment with timolol, a nonselective β-AR antagonist without membrane-stabilizing action, or butoxamine, a selective β2-AR antagonist, at 1 mg/kg increased bone mass in SHR. These results suggested that treatment of SHR with β-blockers at low dose improved bone loss and bone fragility. This antiosteoporotic effect of β-blockers seems to be caused by the blocking action of β2-AR, regardless of the membrane-stabilizing action.
The influence of copper on microstructure and mechanical properties of compacted graphite iron

Abstract The influence of copper content (0·26 to 1·31 wt-%) on microstructure formation and mechanical properties of compacted graphite iron (CGI) has been evaluated through standard metallographic analysis, colour etching techniques and tensile testing of machined test bars. The properties investigated are yield strength, tensile strength and elongation. The castings were made in an industrial environment from a combination of CGI returns, pig iron, cast iron- and steel scrap. A total of four heats were cast in specially designed sampling cups (3 different cooling rates), chill wedges as well as tensile test bars machined from sand moulded cylinders (20, 45 and 85 mm in diameter). The results clearly illustrate the combined effect of copper and cooling rate on nodularity, chilling tendency as well as pearlite content. A discussion concerning the effect of graphite morphology on the ferrite growth is also included.
A dairy and fruit dietary pattern is associated with a reduced likelihood of osteoporosis in Korean postmenopausal women

The aim of the present study was to identify the association of dietary patterns with osteoporosis in Korean postmenopausal women from the Korean Health and Nutrition Examination Survey 2008–10. The present cross-sectional analysis included 3735 postmenopausal women who completed a health interview, nutrition survey and a health examination including bone mineral density (BMD) measurements. The general characteristics and dietary intakes of the participants were obtained using a standardised questionnaire and a 24 h recall method, respectively. The BMD of the femoral neck and lumbar spine was measured using dual-energy X-ray absorptiometry; osteoporosis was defined based on the WHO T-score criteria. Overall, we identified four dietary patterns using factor analysis as follows: ‘meat, alcohol and sugar’, ‘vegetables and soya sauce’, ‘white rice, kimchi and seaweed’ and ‘dairy and fruit’, which accounted for 30·9 % of the total variance in food intake (11·3, 7·7, 6·0 and 5·9 %, respectively). The subjects in the highest quintile of the ‘dairy and fruit’ pattern showed a decreased risk of osteoporosis of the lumbar spine (53 %) compared with those in the lowest quintile, after adjusting for covariates (OR 0·47, 95 % CI 0·35, 0·65, P for trend < 0·0001). In contrast, the ‘white rice, kimchi and seaweed’ dietary pattern was negatively associated with bone health (OR 1·40, 95 % CI 1·03, 1·90, P for trend = 0·0479). The present results suggest that an increased intake of dairy foods and fruits in the traditional Korean diet, based on white rice and vegetables, may decrease the risk of osteoporosis in Korean postmenopausal women.