Miracle-dz/UniFAR-FTUs huggingface dataset:
A Brocard-Ramanujan-type equation with Lucas and associated Lucas sequences

This paper deals with a Brocard-Ramanujan-type equation of the form un1un2 . unk + 1 = u 2 m in unknown nonnegative integers k, n1, n2, . , nk and m with k ≥ 1, where u = (un)∞n=0 is either a Lucas sequence or its associated sequence. For certain infinite families of sequences we completely solve the above equation, extending some results of Marques [15], Szalay [21] and Pongsriiam [18]. The ingredients of the proofs are factorization properties of Lucas sequences, the celebrated result of Bilu, Hanrot and Voutier on primitive divisors of Lucas sequences and elementary estimations concerning the terms involved.
A Survey on Visual Analysis Approaches for Financial Data

Market participants and businesses have made tremendous efforts to make the best decisions in a timely manner under varying economic and business circumstances. As such, decision‐making processes based on Financial data have been a popular topic in industries. However, analyzing Financial data is a non‐trivial task due to large volume, diversity and complexity, and this has led to rapid research and development of visualizations and visual analytics systems for Financial data exploration. Often, the development of such systems requires researchers to collaborate with Financial domain experts to better extract requirements and challenges in their tasks. Work to systematically study and gather the task requirements and to acquire an overview of existing visualizations and visual analytics systems that have been applied in Financial domains with respect to real‐world data sets has not been completed. To this end, we perform a comprehensive survey of visualizations and visual analytics. In this work, we categorize Financial systems in terms of data sources, applied automated techniques, visualization techniques, interaction, and evaluation methods. For the categorization and characterization, we utilize existing taxonomies of visualization and interaction. In addition, we present task requirements extracted from interviews with domain experts in order to help researchers design better systems with detailed goals.
Accuracy evaluation of metal copings fabricated by computer-aided milling and direct metal laser sintering systems

PURPOSE To assess the marginal and internal gaps of the copings fabricated by computer-aided milling and direct metal laser sintering (DMLS) systems in comparison to casting method. MATERIALS AND METHODS Ten metal copings were fabricated by casting, computer-aided milling, and DMLS. Seven mesiodistal and labiolingual positions were then measured, and each of these were divided into the categories; marginal gap (MG), cervical gap (CG), axial wall at internal gap (AG), and incisal edge at internal gap (IG). Evaluation was performed by a silicone replica technique. A digital microscope was used for measurement of silicone layer. Statistical analyses included one-way and repeated measure ANOVA to test the difference between the fabrication methods and categories of measured points (α=.05), respectively. RESULTS The mean gap differed significantly with fabrication methods (P<.001). Casting produced the narrowest gap in each of the four measured positions, whereas CG, AG, and IG proved narrower in computer-aided milling than in DMLS. Thus, with the exception of MG, all positions exhibited a significant difference between computer-aided milling and DMLS (P<.05). CONCLUSION Although the gap was found to vary with fabrication methods, the marginal and internal gaps of the copings fabricated by computer-aided milling and DMLS fell within the range of clinical acceptance (<120 µm). However, the statistically significant difference to conventional casting indicates that the gaps in computer-aided milling and DMLS fabricated restorations still need to be further reduced.
Normalisation of insulin‐like growth factor‐I does not improve insulin action in cirrhosis

Cirrhosis of the liver is characterised by insulin resistance and low levels of insulin‐like growth factor I (IGF‐I). Lack of IGF‐I may contribute to this insulin resistance, as IGF‐I increases insulin sensitivity. This study aimed to determine the effects of normalisation of IGF‐I on insulin action in cirrhosis.
Phosphorylation of estrogen receptor α at serine 118 is correlated with breast cancer resistance to tamoxifen

The aim of the present study was to explore the correlation between estrogen receptor α (ERα) phosphorylation at serines 118 and 167 and the responsiveness of patients with primary breast cancer to tamoxifen. Tumors from 104 patients with primary breast cancer who received adjuvant tamoxifen therapy at The Affiliated Cancer Hospital of Shantou University Medical College between January 2001 to December 2007 were subjected to immunohistochemical analysis with specific antibodies against ERα phosphorylated at either serine 118 (pERα-S118) and/or serine 167 (pERα-S167). ERα phosphorylation at the two sites was correlated with either the disease-free survival or the overall survival rate of these patients using the Kaplan-Meier survival analysis. pERα-S118 and pERα-S167 were found to be expressed in the cell nucleus of 25.0% (26/104) and 26.9% (28/104) of breast cancers, respectively. The expression of pERα-S118 was positively correlated with the human epidermal growth factor receptor-2 (HER-2) status (χ2=6.85, P=0.01). The Kaplan-Meier analysis revealed a poorer disease-free (P=0.022) and overall survival (P=0.013) in breast cancer patients expressing pERα-S118, but not in those expressing pERα-S167. In conclusion, pERα-S118 was correlated with the HER-2 status and predicted breast cancer resistance to tamoxifen.
Fibrinolysis for Intraventricular Hemorrhage: An Updated Meta-Analysis and Systematic Review of the Literature

Background and Purpose— Intraventricular hemorrhage is associated with high mortality and poor functional outcome. The use of intraventricular fibrinolytic (IVF) therapy as an intervention in intraventricular hemorrhage is an evolving therapy with conflicting reports in the literature. The goal of this study is to investigate the impact of IVF on mortality, functional outcome, ventriculitis, shunt dependence, and rehemorrhage. Methods— During March and April 2014, a systematic literature search was performed identifying 1359 articles. Of these, 24 met inclusion criteria. A random effects meta-analysis was performed using both pooled and subset analysis based on study type. Results— Our meta-analysis demonstrated that IVF reduced mortality in intraventricular hemorrhage by nearly half (relative risk [RR], 0.55; 95% confidence interval [CI], 0.42–0.71; P<0.00001), increased the likelihood of good functional outcome by 66% (RR, 1.66; 95% CI, 1.27–2.19; P=0.0003), and also decreased the rate of shunt dependence (RR, 0.62; 95% CI, 0.42–0.93; P=0.02). IVF was not found to be associated with increased rates of ventriculitis (RR=1.46; 95% CI, 0.77–2.76; P=0.25) or rehemorrhage (RR=1.06; 95% CI, 0.66–1.70; P=0.80). We detected no evidence of publication bias. Conclusions— Our meta-analysis showed that IVF is safe and could be an effective strategy for the treatment of intraventricular hemorrhage. It may reduce mortality, improve functional outcome, and diminish the need for permanent ventricular shunting, while not increasing the risk of ventriculitis or rehemorrhage.
Temporal colinearity and the phylotypic progression: a basis for the stability of a vertebrate Bauplan and the evolution of morphologies through heterochrony.

Vertebrate Hox genes are essential for the proper organization of the body plan during development. Inactivation of these genes usually leads to important alterations, or transformations, in the identities of the affected developing structures. Hox genes are activated in a progressive temporal sequence which is colinear with the position of these genes on their respective complexes, so that 'anterior' genes are activated earlier than 'posterior' ones (temporal colinearity). Here, an hypothesis is considered in which the correct timing of activation of this gene family is necessary in order to properly establish the various expression domains. Slight modifications in the respective times of gene activation (heterochronies) may shift expression domains along the rostrocaudal axis and thus induce concurrent changes in morphologies. It is further argued that temporal colinearity only occurs in cells with high mitotic rates, which results in a strong linkage between patterning and growth control and makes the patterning process unidirectional, from anterior, proximal and early, to posterior, distal and late, a model referred to as the 'Einbahnstrasse'. While the nature of the mechanism(s) behind temporal and spatial colinearities is unknown, it is proposed that such a mechanism relies on meta-cis interactions, that is it may necessitate gene contiguity. Such a mechanism would be based on DNA-specific, rather than gene-specific, features such as chromatin configurations or DNA replication. The existence of such a meta-cis mechanism would explain the extraoridinary conservation of this genetic system during evolution as its basic properties would be linked to that of the genetic material itself. (ABSTRACT TRUNCATED AT 250 WORDS)
Early Results of a Helmetless-Tackling Intervention to Decrease Head Impacts in Football Players.

OBJECTIVE To test a helmetless-tackling behavioral intervention for reducing head impacts in National Collegiate Athletic Association Division I football players. DESIGN Randomized controlled clinical trial. SETTING Football field. PATIENTS OR OTHER PARTICIPANTS Fifty collegiate football players (intervention = 25, control = 25). INTERVENTION(S) The intervention group participated in a 5-minute tackling drill without their helmets and shoulder pads twice per week in the preseason and once per week through the season. During this time, the control group performed noncontact football skills. MAIN OUTCOME MEASURE(S) Frequency of head impacts was recorded by an impact sensor for each athlete-exposure (AE). Data were tested with a 2 × 3 (group and time) repeated-measures analysis of variance. Significant interactions and main effects (P < .05) were followed with t tests. RESULTS Head impacts/AE decreased for the intervention group compared with the control group by the end of the season (9.99 ± 6.10 versus 13.84 ± 7.27, respectively). The intervention group had 30% fewer impacts/AE than the control group by season's end (9.99 ± 6.10 versus 14.32 ± 8.45, respectively). CONCLUSION A helmetless-tackling training intervention reduced head impacts in collegiate football players within 1 season.
Initial component control in disparity vergence: a model-based study

The dual-mode theory for the control of disparity-vergence eye movements states that two components control the response to a step change in disparity. The initial component uses a motor preprogram to drive the eyes to an approximate final position. This initial component is followed by activation of a late component operating under visual feedback control that reduces residual disparity to within fusional limits. A quantitative model based on a pulse-step controller, similar to that postulated for saccadic eye movements, has been developed to represent the initial component. This model, an adaptation of one developed by D.S. Zee et al. (J. Neurophysiol., vol. 68, p. 1624-41, 1992), provides accurate simulations of Isolated initial component movements and is compatible with the known underlying neurophysiology and existing neurophysiological data. The model has been employed to investigate the difference in dynamics between convergent and divergent movements. Results indicate that the pulse-control component active in convergence is reduced or absent from the control signals of divergence movements. This suggests somewhat different control structures of convergence versus divergence, and is consistent with other directional asymmetries seen in horizontal vergence.
Association between polymorphism of the NQO1, NOS3 and NFE2L2 genes and AMD.

Oxidative stress may play a role in the pathogenesis of age-related macular degeneration (AMD). In this study we examined the association between AMD risk and polymorphisms of genes encoding enzymes involved in the generation and removal of iron-mediated oxidation: NQO1 (609C> T, rs1800566), NOS3 (894G>T, rs1799983) and NFE2L2 (28312647A>G, rs6726395). We found that the G/G genotype of the rs6726395 polymorphism was associated with a decreased risk of AMD wet form (OR 0.44) and on the other hand the T allele of the rs1799983 polymorphism increased such risk (OR 1.63). We also observed that the C/C-G/T combined genotype of the rs1800566 and rs1799983 polymorphisms was positively correlated with a reduced risk of AMD as well as of its dry form (OR 0.40 and 0.35). The presence of the G/T-G/G combined genotype of the rs1799983 and rs6726395 polymorphisms decreased the risk of this disease (OR 0.35). The results obtained in our study suggest a potential role of the rs1800566, rs1799983 and rs6726395 polymorphisms in the AMD pathogenesis.
Parallel scheduling for cyber-physical systems: Analysis and case study on a self-driving car

As the complexity of software for Cyber-Physical Systems (CPS) rapidly increases, multi-core processors and parallel programming models such as OpenNP become appealing to CPS developers for guaranteeing timeliness. Hence, a parallel task on multi-core processors is expected to become a vital component in CPS such as a self-driving car, where tasks must be scheduled in real-time. In this paper, we extend the fork-join parallel task model to be scheduled in real-time, where the number of parallel threads can vary depending on the physical attributes of the system. To efficiently schedule the proposed task model, we develop the task stretch* transform. Using this transform for global Deadline Monotonic scheduling for fork-join real-time tasks, we achieve a resource augmentation bound of 3.73. In other words, any task set that is feasible on m unit-speed processors can be scheduled by the proposed algorithm on m processors that are 3.73 times faster. The proposed scheme is implemented on Linux/RK as a proof of concept, and ported to Boss, the self-driving vehicle that won the 2007 DARPA Urban Challenge. We evaluate our scheme on Boss by showing its driving quality, i.e., curvature and velocity profiles of the vehicle.
Risk-adapted management of differentiated thyroid cancer assessed by a sensitive measurement of basal serum thyroglobulin.

CONTEXT Treatment and follow-up of patients thyroidectomized for differentiated thyroid carcinoma (DTC) mainly depends on the identification of the patient's risk of recurrence. Thyroglobulin (Tg) is the most important marker of persistent/recurrent disease. The recent introduction of a new, more sensitive Tg measurement allows for the early detection of the disease by measuring the basal (under L-T(4) therapy) serum Tg level without TSH stimulation. OBJECTIVE The goal of this study is to identify the basal serum Tg threshold value that indicates recurrent disease by using a second-generation Tg assay. DESIGN AND PATIENTS A continuous series of 425 DTC patients, all thyroidectomized and treated with (131)I after surgery and having basal Tg of no more than 1.0 ng/ml, negative anti-Tg antibodies, and a recombinant human TSH-stimulated Tg measurement was retrospectively analyzed. SETTING The study took place at an academic hospital. RESULTS The most accurate basal Tg value for predicting the presence of recurrent/residual disease was more than 0.15 ng/ml (sensitivity 87%, specificity 91%, negative predictive value 98.6%, and positive predictive value 47.8%). When the basal Tg level was no more than 0.15 ng/ml, the risk of disease presence was very low, even in patients classified at an intermediate or high risk. In contrast, when the basal Tg level was more than 0.15 ng/ml, the percentage of recurrent disease was relatively high (12.5% or one in eight cases) in low-risk patients. CONCLUSIONS Basal Tg, measured using a second-generation Tg assay allows for the identification of DTC patients who are likely to remain disease free with great accuracy. This simple measurement, therefore, may be sufficient to assess the risk-adapted management of DTC patients.
Particle Swarm Optimization in High-Dimensional Bounded Search Spaces

When applying particle swarm optimization (PSO) to real world optimization problems, often boundary constraints have to be taken into account. In this paper, we show that the bound handling mechanism essentially influences the swarm behavior, especially in high-dimensional search spaces. In our theoretical analysis, we prove that all particles are initialized very close to the boundary with overwhelming probability, and that the global guide is expected to leave the search space in every forth dimension. Afterwards, we investigate the initialization process when optimizing the sphere function, a widely used benchmark, in more detail in order to provide a first step towards explaining previously observed phenomena. Moreover, we present a broad experimental study of commonly applied bound handling mechanisms on a variety of benchmark functions which is useful for choosing an appropriate strategy in real world applications. Finally, we derive some guidelines for the practical application of the PSO algorithm in high-dimensional bounded search spaces
Root Canal Morphology of Mandibular Canine in an Iranian Population: A CBCT Assessment

Introduction: The present study was conducted to assess the morphology of mandibular canines using cone-beam computed tomography (CBCT) in a north Iranian population. Methods and Materials: For the morphological assessment of mandibular canines, 150 CBCT images taken from patients for different reasons were used. The mandibular canines were examined in sagittal, coronal and axial dimensions. The canal pattern, number of roots/canals, the tooth length, the orientation of the roots and the position of the apical foramina were evaluated and the effect of gender on each variable was assessed. The obtained data were analyzed using the Chi-square and student’s t-tests. Results: According to the Vertucci’s criteria, the most common pattern was type I morphology (89.7%), followed by types III (5.7%), II (3.7%) and V (1%). No significant differences were observed between the male and female patients in terms of canal type (P>0.05). Gender difference is a factor which affected the root length and the number of mandibular canine root and root canal. There were 296 single-root and four double-root canines. The double-root canines and mandibular canine with two canals were significantly more common among men than women (P=0.00). The apical foramen was laterally positioned in 68.3% and centrally in 31.7% of the cases, and the root curvatures were mostly oriented toward the buccal region. No significant statistical difference was observed for mentioned parameters in right and left half of the jaw. Conclusion: Due the diverse morphology and the potential presence of a second mandibular canine among Iranians, dentists should perform endodontic treatments with greater care. CBCT is an accurate tool for the morphological assessment of root canals.
Multiple Drug Resistant Enterobacter Agglomerans and Pseudomonas Aeruginosa Causing Conjunctivitis in Swamp Buffaloes in Nagaland

Conjunctivitis (Pink eye) is often infectious and caused by either bacterial or viral infections. Ampicillin, gentamicin, nitrofurantoin and cephalexin resistant Enterobacter agglomerans and Pseudomonas aeruginosa were isolated from two cases of acute conjunctivitis in swamp buffaloes in Nagaland,. Treatment with tetracycline eye drop resulted in cure within three days. Isolation of multiple drug resistant (MDR) strains from swamp buffaloes, never exposed earlier for antimicrobials, is of significance in understanding spread of MDR strains. It seems to be the first report of isolation of Enterobacter agglomerans from conjunctivitis case of swamp buf-
UvA-DARE (Digital Academic Repository) Ideology as Resource in Entrepreneurial Journalism

The emergence of a startup culture in the ﬁ eld of journalism is global: since the early years of the twenty- ﬁ rst century, new independent journalism companies have formed around the world. Although setting up one ’ s own journalistic practice is not particularly novel in the news industry, the last couple of years have witnessed exponential growth in the startup space. In this context we chose to look more closely at one of the more successful recent online news startups: the French site Mediapart . We were interested in the factors involved in creating and running a journalism startup, and how the professionals involved give meaning to what they do in the fast-changing journalism ﬁ eld. We found that, although one of the main unique selling points of the journalism professed at Mediapart is that it challenges and provides an alternative to mainstream French press, at the heart of it is a strong traditional journalism ideology. While Mediapart has in many ways challenged and inspired the ways in which other French news organizations operate, it does not challenge our understanding of journalism, but rather reinforces a traditional and homogenous de ﬁ nition.
Influence of different preservation solutions and intentional hemodilution of recipient on viability of preserved and transplanted rat kidneys

A total of 81 rat kidney grafts, flushed out and cold stored in either Sacks' or University of Wisconsin (UW) solution, were transplantated into hemodiluted (Hct=30%±4%) or untreated (Hct=43%±3%) recipients. The cold ischemia times (CIT) used were 24 and 36 h. One week after transplantation, the surviving recipients (n=67) were contralaterally nephrectomized. The experiment was terminated after a total period of 4 weeks, and the percentage of surviving animals were determined for each treatment. Data was pooled and the results show that grafts cold stored in UW solution were viable to a significantly greater extent and after longer CIT than grafts cold stored in Sacks' solution (47% vs 23%;P<0.05). Recipient hemodilution did not improve graft viability (39% vs 32%; NS). Kidneys cold stored for 24 h were viable to a greater extent than kidneys with a CIT of 36 h (50% vs 15%;P<0.01).
HIV testing in black Africans living in England

SUMMARY We examined the uptake of HIV testing in black Africans living in England before the introduction of national testing guidelines. Analyses were conducted using data from an anonymous self-completed questionnaire linked to oral fluid samples to establish HIV status in black Africans attending community venues in England in 2004. Of 946 participants, 44% had ever been tested for HIV and 29% had been tested in the previous 24 months. Of those with undiagnosed HIV, 45% had previously had a negative HIV test. Almost a third of people tested in the UK had been at general practice. Uptake of HIV testing was not associated with perceived risk of HIV. These findings highlight the need for the implementation of national HIV testing guidelines in the UK, including the promotion of testing in general practice. Regular testing in black Africans living in the UK should be promoted regardless of their HIV test history.