Miracle-dz/UniFAR-FTUs huggingface dataset:
Measuring and Ranking status of career anchors of employeesand its effect on the success of career

Abstract. The purpose of this study is to Measure and Rank status of career anchors of employees and its effect onthe success of career. Through Stratified sampling and Morgan formula, 250 employees have been chosen. Two questionnaires for data collection has been used. Data has been analyzed by Descriptive Statistics and Spearman correlation, Kolmogorov–Smirnov tests in SPSS software. Study showed that there are an inverse relationship between anchors and Subjective success of career. With increase gap between the current and desired status of each career anchors, subjective success of career decreases. The evaluating and ranking career anchors showed that respectively Security / stability, Dedication to a purpose, Creation and entrepreneurship, Competence of Public Administration, Pure Challenge, Technical / task competence, Lifestyle are highest rank.
Deep brain stimulation improves orthostatic regulation of patients with Parkinson disease

Objective: To evaluate whether subthalamic nucleus (STN) stimulation has an effect on the orthostatic regulation of patients with Parkinson disease (PD), we studied cardiovascular regulation during on and off phases of STN stimulation. Methods: We examined 14 patients with PD (mean age 58.1 ± 5.8 years, 4 women, 10 men) with bilateral STN stimulators. Patients underwent 3 minutes of head-up tilt (HUT) testing during STN stimulation and after 90 minutes interruption of stimulation. We monitored arterial blood pressure (BP), RR intervals (RRI), respiration, and skin blood flow (SBF). Baroreflex sensitivity (BRS) was assessed as the square root of the ratio of low-frequency power of RRI to the low-frequency power of systolic BP for coherences above 0.5. Results: During the on phase of the STN stimulation, HUT induced no BP decrease, a significant tachycardia, and a significant decrease of SBF. During the off phase of stimulation, HUT resulted in significant decreases in BPsys and RRI and only a slight SBF decrease. HUT induced no change of BRS during stimulation, but lowered BRS when the stimulator was off (p < 0.05). Conclusions: STN stimulation of patients with PD increases peripheral vasoconstriction and BRS and stabilizes BP, thereby improving postural hypotension in patients with PD. The results indicate that STN stimulation not only alleviates motor deficits but also influences autonomic regulation in patients with PD.
Development of a Low Bias Method for Characterizing Viral Populations Using Next Generation Sequencing Technology

Background With an estimated 38 million people worldwide currently infected with human immunodeficiency virus (HIV), and an additional 4.1 million people becoming infected each year, it is important to understand how this virus mutates and develops resistance in order to design successful therapies. Methodology/Principal Findings We report a novel experimental method for amplifying full-length HIV genomes without the use of sequence-specific primers for high throughput DNA sequencing, followed by assembly of full length viral genome sequences from the resulting large dataset. Illumina was chosen for sequencing due to its ability to provide greater coverage of the HIV genome compared to prior methods, allowing for more comprehensive characterization of the heterogeneity present in the HIV samples analyzed. Our novel amplification method in combination with Illumina sequencing was used to analyze two HIV populations: a homogenous HIV population based on the canonical NL4-3 strain and a heterogeneous viral population obtained from a HIV patient's infected T cells. In addition, the resulting sequence was analyzed using a new computational approach to obtain a consensus sequence and several metrics of diversity. Significance This study demonstrates how a lower bias amplification method in combination with next generation DNA sequencing provides in-depth, complete coverage of the HIV genome, enabling a stronger characterization of the quasispecies present in a clinically relevant HIV population as well as future study of how HIV mutates in response to a selective pressure.
Counterfactuals and Causal Inference by Stephen L. Morgan

• page 9, last paragraph, line 1: remove “the” in “of the Campbell’s perspective” • page 34, line 4, replace “of population” with “of the population” • page 34, line 8, replace “individuals’s” with “individual’s” • page 34, notes line 3, replace “observational” with “observed” • page 36, line 17, replace “the causal effect” with “the expected causal effect” • page 37, line 2, replace “In general, the average causal effect is” with “The average causal effect is also” • page 37, line 15 from the bottom, replace “as well” with “as well as” • page 46, 7th line below Equation 2.12: replace {(1 ⇡)E[ |D = 1] E[ |D = 0]} with (1 ⇡){E[ |D = 1] E[ |D = 0]} (Note: Equation 2.12 is correct, and the { in the text is misplaced). • page 52, line 15 from the bottom, replace “that is” with “that it is” • page 54, Table 2.4, line 2: Add “. ” between “Observable as Y ” and “Counterfactual” in the column under the heading “. ” • page 62, line 9 from the bottom: remove one “to” from “shock to to the cause” • page 69, line 4: remove one “any” from “any any sequence of edges” • page 77, footnote 14, line 7, replace E[Y |do(D = 1] with E[Y |do(D = 1)] • page 94, third displayed equation: replace 3(.6) + 2.4(.4) = 2.64 with 3(.4) + 2.4(.6) = 2.64 • page 103, Equation 4.13: replace “n1” with “1” in the denominator of the first term so that the equation is
Inflammatory Demyelinating Central Nervous System Diseases in Childhood: Clinical and Paraclinical Profiles in 133 Patients

In a retrospective review of patients with acquired demyelinating disorders of the central nervous system, 133 patients (5.6%) whose diseases started in childhood, were selected from 2369 patients, who had medical records in the Neurology Department of Dokuz Eylul University. Out of 133, 98 had relapsing remitting multiple sclerosis, 21 had secondary progressive multiple sclerosis, 8 had clinically isolated syndrome, 3 had neuromyelitis optica, 2 had Marburg disease, and 1 had radiologically isolated syndrome. In 55 patients (41.3%), disease onset was before age 16. Polysymptomatic presentation (22.6%) was the most common initial feature. The EDSS scores ranged from 0 to 9 with a median of 2.0 (2.22 ± 1.88) for 126 patients. MRI records of 111 patients were obtained. 97 patients had clinically definite multiple sclerosis. 11 MS patients (11.3%) did not initially present the diagnostic MRI features. All of the remaining multiple sclerosis patients fulfilled Barkhof-Tintore criteria (100%) and 88.7% fulfilled KIDMUS criteria. Cranial MRI of NMO patients was normal. Our findings demonstrate some important clinical and paraclinical features that can help the literature on acquired demyelinating disorders of childhood by utilizing data from Western Turkey.
Fragile X-Associated Tremor/Ataxia Syndrome: From Molecular Pathogenesis to Development of Therapeutics

Fragile X-associated tremor/ataxia syndrome (FXTAS) is a neurodegenerative disorder caused by a premutation CGG repeat expansion (55–200 repeats) within the 5′ UTR of the fragile X gene (FMR1). FXTAS is characterized by intension tremor, cerebellar ataxia, progressive neurodegeneration, parkinsonism and cognitive decline. The development of transgenic mouse and Drosophila melanogaster models carrying an expanded CGG repeat has yielded valuable insight into the pathophysiology of FXTAS. To date, we know of two main molecular mechanisms of this disorder: (1) a toxic gain of function of the expanded CGG-repeat FMR1 mRNA, which results in the binding/sequestration of the CGG-binding proteins; and (2) CGG repeat-associated non-AUG-initiated (RAN) translation, which generates a polyglycine peptide toxic to cells. Besides these CGG-mediated mechanisms, recent studies have shed light on additional mechanisms of pathogenesis, such as the antisense transcript ASFMR1, mitochondrial dysfunction, DNA damage from R-loop formation and 5-hydroxymethylcytosine (5hmC)-mediated epigenetic modulation. Here we summarize the recent progress towards understanding the etiology of FXTAS and provide an overview of potential treatment strategies.
Inhibition of FK506 Binding Proteins Reduces α-Synuclein Aggregation and Parkinson's Disease-Like Pathology

α-Synuclein (α-SYN) is a key player in the pathogenesis of Parkinson's disease (PD). In pathological conditions, the protein is present in a fibrillar, aggregated form inside cytoplasmic inclusions called Lewy bodies. Members of the FK506 binding protein (FKBP) family are peptidyl-prolyl isomerases that were shown recently to accelerate the aggregation of α-SYN in vitro. We now established a neuronal cell culture model for synucleinopathy based on oxidative stress-induced α-SYN aggregation and apoptosis. Using high-content analysis, we examined the role of FKBPs in aggregation and apoptotic cell death. FK506, a specific inhibitor of this family of proteins, inhibited α-SYN aggregation and neuronal cell death in this synucleinopathy model dose dependently. Knockdown of FKBP12 or FKBP52 reduced the number of α-SYN aggregates and protected against cell death, whereas overexpression of FKBP12 or FKBP52 accelerated both aggregation of α-SYN and cell death. Thus, FK506 likely targets FKBP members in the cell culture model. Furthermore, oral administration of FK506 after viral vector-mediated overexpression of α-SYN in adult mouse brain significantly reduced α-SYN aggregate formation and neuronal cell death. Our data explain previously described neuroregenerative and neuroprotective effects of immunophilin ligands and validate FKBPs as a novel drug target for the causative treatment of PD.
The relationship between emotional intelligence and academic satisfaction in students

Introduction: The aim of this study was to determine the difference between students with type D personality and non type D personality in regard to general health. Method: This study was conducted using survey design and cross-sectional method. Data were collected from 248 students of Yazd University, from seven educational groups. These students were selected via random sampling. The instruments for gathering data were standardized scales: Type D Personality Questionnaire (TDPQ) and General Health Questionnaire (GHQ). Results: The results showed a significant difference between students with type D personality and non-type D personality in regard to general health, and in regard to components of general health: somatic symptoms, anxiety/ insomnia, social dysfunction, and severe depression. Hierarchical multiple regression analysis showed that the negative affectivity and social inhibition explained for %7.3 of the variance in general health. Conclusion: Type D personality is a powerful construct in explanation and prediction of students’ general health. Therefore, results of this study can be used to reinforce students’ general health through interventionist activities.
SIP Server Overload Control : Design and Evaluation

A SIP server may be overloaded by emergency-induced call volume, “American Idol” style flash crowd effects or denial of service attacks. The SIP server overload problem is interesting especially because the costs of serving or rejecting a SIP session can be similar. For this reason, the built-in SIP overload control mechanism based on generating rejection messages cannot prevent the server from entering congestion collapse under heavy load. The SIP overload problem calls for a pushback control solution in which the potentially overloaded receiving server may notify its upstream sending servers to have them send only the amount of load within the receiving server’s processing capacity. The pushback framework can be achieved by either a rate-based feedback or a window-based feedback. The centerpiece of the feedback mechanism is the algorithm used to generate load regulation information. We propose three new window-based feedback algorithms and evaluate them together with two existing rate-based feedback algorithms. We compare the different algorithms in terms of the number of tuning parameters and performance under both steady and variable load. Furthermore, we identify two categories of fairness requirements for SIP overload control, namely, user-centric and provider-centric fairness. With the introduction of a new double-feed SIP overload control architecture, we show how the algorithms can meet those fairness criteria.
Effective Pre-school and Primary Education 3-11 Project (EPPE 3-11) Influences on children's attainment and progress in Key Stage 2: Cognitive outcomes in Year 5 Research brief

Effective Pre-School and Primary Education 3-11 (EPPE 3-11) (2003-2008) builds on the work of the earlier Effective Provision of Pre-School Education (EPPE) project (1996-2003) which investigated the impact of preschool provision on a national sample of young children in England between the ages of 3 and 7 years. EPPE 3-11 is following the same sample of around 2,500 children to age 11, the end of Key Stage 2. This Research Brief focuses on the relationships between various child, family, home, pre-school and primary school characteristics and measures of children’s cognitive attainment in Year 5 of primary school (age 10). It compares these findings to the impact of the same factors when the children were in Year 1 (age 6). The brief also reports findings about the combined influence of pre-school and primary school experience on children’s cognitive attainment in Year 5.
Volumetric measure of the frontal and temporal lobe regions in schizophrenia: relationship to negative symptoms.

BACKGROUND Previous research has provided evidence for brain abnormalities in schizophrenia, but their relationship to specific clinical symptoms and syndromes remains unclear. METHODS With an all-male demographically similar sample of 53 schizophrenic patients and 29 normal control subjects, cerebral gray and white matter volumes (adjusted for intracranial volume and age were determined for regions in the prefrontal lobe and in the superficial and mesial temporal lobe using T1-weighted magnetic resonance imaging with 2.8-mm coronal slices. RESULTS As a group, schizophrenic patients had wide-spread bilateral decrements in gray matter in the pre-frontal (7.4%) and temporal lobe regions (8.9%), but not in white matter in these regions. In the temporal lobe, gray matter reductions were found bilaterally in the superior temporal gyrus (6.0%), but not in the hippocampus and parahippocampus. While there were no overall group differences in white matter volumes, widespread decrements in prefrontal white matter in schizophrenic patients (n = 53) were related to higher levels of negative symptoms (partial r[49] = -0.42, P = .002), as measured by the Scale for the Assessment of Negative Symptoms. A post hoc analysis revealed that schizophrenic patients with high negative symptoms had generalized prefrontal white matter reductions (11.4%) that were most severe in the orbitofrontal subregion (15.1%). CONCLUSIONS These results suggest that gray matter deficits may be a fairly common structural abnormality of schizophrenia, whereas reductions in prefrontal white matter may be associated with schizophrenic negative symptoms.
Coach Brogan: South Central High School's Answer to Academic Achievement

How can one man make a difference for bright, young men? In an ethnographic study of high ability young men in an urban high school, one coach's influence was found to be crucial in motivating gifted males. Coach Brogan developed effective strategies to maintain high academic achievement amongst his championship athletes. This article presents a description of the culture of achievement surrounding the men's swim team at South Central High School and the strategies offered by the successful coach/educator.
Memory Errors in Modern Systems: The Good, The Bad, and The Ugly

Several recent publications have shown that hardware faults in the memory subsystem are commonplace. These faults are predicted to become more frequent in future systems that contain orders of magnitude more DRAM and SRAM than found in current memory subsystems. These memory subsystems will need to provide resilience techniques to tolerate these faults when deployed in high-performance computing systems and data centers containing tens of thousands of nodes. Therefore, it is critical to understand the efficacy of current hardware resilience techniques to determine whether they will be suitable for future systems. In this paper, we present a study of DRAM and SRAM faults and errors from the field. We use data from two leadership-class high-performance computer systems to analyze the reliability impact of hardware resilience schemes that are deployed in current systems. Our study has several key findings about the efficacy of many currently deployed reliability techniques such as DRAM ECC, DDR address/command parity, and SRAM ECC and parity. We also perform a methodological study, and find that counting errors instead of faults, a common practice among researchers and data center operators, can lead to incorrect conclusions about system reliability. Finally, we use our data to project the needs of future large-scale systems. We find that SRAM faults are unlikely to pose a significantly larger reliability threat in the future, while DRAM faults will be a major concern and stronger DRAM resilience schemes will be needed to maintain acceptable failure rates similar to those found on today's systems.
Touchpoints: Your Child's Emotional and Behavioral Development

"Touchpoints" are the spurts of development, and the trying periods of regression that accompany them, throughout childhood. From pregnancy to first gradxe, all the concerns and questions that parents have about their child's behavior, feelings, and development are anticipated and answered in both chronological and reference form. (Addison-Wesley)
Structural abnormalities in brain magnetic resonance images of depressed children.

OBJECTIVE Brain magnetic resonance images (MRIs) of 65 children and adolescents who were hospitalized with depressive disorders (DD) were compared with the brain MRIs of 18 hospitalized psychiatric controls (PC) without a depressive disorder. METHOD Volumetric analyses were used to measure frontal lobe volumes (FLV), lateral ventricular volumes (VV), and total cerebral volumes (CV) for all subjects. To correct for differences in absolute cerebral volume associated with different body and head size, the ratios of FLV/CV and VV/CV were used to compare differences between the two groups. A multivariate analysis was used to control for the effects of several independent variables (age, sex, diagnosis). RESULTS Significant differences were seen in the FLV/CV ratio and the VV/CV ratio when the results were compared between the two groups (DD versus PC). The DD group had a significantly smaller FLV/CV ratio (t = 2.148, df = 79, p = .035) and a significantly larger VV/CV ratio (t = -2.093, df = 79, p = .040). CONCLUSION The findings are consistent with previous reports in depressed adults and may implicate the frontal lobes in the pathogenesis of early-onset depressive disorders.
Social Disadvantage and Child Emotional and Behavioural Problems: At HOME in the Netherlands

markdownabstract__Abstract__ Past research has repeatedly emphasised the important role of children's home environments in shaping their development. There is ample evidence that children who have limited access to age-appropriate learning materials in the home more often manifest behavioural problems. Poor physical conditions of the home, such as low housing quality, have been linked to children's emotional problems. The present thesis examines prospective associations of observed infants' home environments with emotional and behavioural problems. All studies included in this thesis were conducted within the context of the Generation R Study, a large population-based cohort from foetal life onward in Rotterdam, the Netherlands.
New method to calculate creatinine generation rate using pre- and postdialysis creatinine concentrations.

The creatinine (Cr) generation rate reflects the muscle mass, a possible indicator of protein nutritional status. Thus, in this study, we developed equations for calculating the Cr generation rate. Depner and Daugirdas recently developed a method for determining the protein catabolic rate (PCR) from the pre- and postdialysis blood urea nitrogen concentrations. We modified their method to develop equations for calculating the total Cr generation rate from the measured predialysis Cr concentration and estimated postrebound concentration. The total Cr generation rate is defined as the sum of the intrinsic Cr generation rate and the extrinsic Cr generation rate (i.e., the generation rate of Cr derived from food). In the present study, the postrebound Cr concentration was estimated on the basis of postdialysis Cr concentration and the K/V for Cr. The intrinsic Cr generation rate was obtained by subtracting the extrinsic Cr generation rate, which was estimated on the basis of the PCR, from the total Cr generation rate calculated. The intrinsic Cr generation rate determined with this method was virtually the same as that obtained using the postrebound Cr concentration, the concentration immediately before the next hemodialysis (HD) session, and the PCR. The intrinsic Cr generation rate determined with the present method did not vary with changes in the HD prescription (i.e., with an increase in blood flow rate, a prolongation of the HD duration time, or a change in dialyzer membrane area). The present study also indicated that the intrinsic Cr generation rate decreased with age in both males and females.
Team change climate: A group-level analysis of the relationships among change information and change participation, role stressors, and well-being

We explored whether teams develop shared perceptions regarding the quantity and quality of information and the extent of participation in decision making provided in an environment of continuous change. In addition, we examined whether change climate strength moderated relationships between change climate level and team outcomes. We examined relationships among aggregated change information and change participation and aggregated team outcomes, including two role stressors (i.e., role ambiguity and role overload) and two indicators of well-being (i.e., quality of worklife and distress). Questionnaires were distributed in an Australian law enforcement agency and data were used from 178 teams. Structural equation modelling analyses, controlling for a marker variable, were conducted to examine the main effects of aggregated change information and aggregated change participation on aggregated team outcomes. Results provided support for a model that included method effects due to a marker variable. In this model, change information climate was significantly negatively associated with role ambiguity, role overload, and distress, and significantly positively associated with quality of worklife. Change participation climate was significantly positively associated with quality of worklife. Change climate strength did not moderate relationships among change climate level and team outcomes.