Miracle-dz/UniFAR-FTUs huggingface dataset:
Subsidies for sustainable production: Effects of changing subsidy level

A multi-trial duopoly price-setting game was used to investigate the potential ef-fectiveness of a subsidy system aimed at reducing sales and thereby production of environmentally harmful products. In real life it is however likely that a subsidy level will never remain fixed, either nominally or in real value. Producers may also have unreliable perceptions of the subsidy level even if it does not change. Therefore, a subsidy, either fixed and known, varying randomly, or varying sys-tematically across trials, was investigated. The results showed that both fixed and known, as well as varying subsidy levels led to higher prices and thus re-duced sales compared to without a subsidy. Knowledge of a fixed subsidy level or expectations about a subsidy level based on previous trials, appeared to make participants refrain from setting lower prices than the subsidy level. Further-more, the results indicated that participants attempted to maximize their profit by selling to the lowest price, thus they stayed competitive and did not exploit the subsidy.
Nationalism, Identity and the Governance of Diversity: Old Politics, New Arrivals

1. Immigrant Newcomers and the Old Politics of Nationalism 2. Nationalism, Decentralization and the Politics of Migration 3. Taming the Trojan Horse: Quebec and the Politics of Demography 4. Managing Multiple Diversities: Belgian Federalism and the Flemish Politics of Integration 5. Civic and Economic Nationalism: the Scottish Turn to Immigration 6. Challenges and Opportunities of Governing Diversity in the Multinational Society
NEGOTIATION AND MEDIATION

INTRODUCTION 532 Other Procedures for Dealing with Opposing Preferences . 532 THE STUDY OF NEGOTIATION 533 ISSUES, LIMITS, AND OUTCOMES IN NEGOTIATION . 535 The Nature of Issues . " . " . " . 535 Options, Limits, and Outcomes . " . " . "" 535 Determinants of Limits . " . ". 537 MOTIVATION AND STRATEGY IN N EGOTIATION. 538 Strategic Choice. 538 Motivational Orientations . " . " . """",,. """,,",,"". 539 The Dual Concern Model . " . "" . """". 539 Research on Concession Making . 543 Research on Contending. 548 Research on Problem Solving . " . ". 550 Conclusions about Motivation and Strategy . ". 553 COGNITIVE PROCESSES IN NEGOTIATION 553 Heuristics and Biases . 554 Schematic 1nformation Processing . " . ". 557 Perspective on the Cognitive Approach """"""""""""""""""""""""""" 559 MEDIATION. 56 1 History and Literature . 56 1 Mediation Effectiveness . 562
Hydrodynamics of a Relativistic Fireball: The Complete Evolution

We study numerically the evolution of an adiabatic relativistic fireball expanding into a cold uniform medium. We follow the stages of initial free expansion and acceleration, coasting, and then deceleration and slowing down to a nonrelativistic velocity. We compare the numerical results with simplified analytical estimates. We show that the relativistic self-similar Blandford-McKee solution describes well the relativistic deceleration epoch. It is an excellent approximation throughout the relativistic deceleration stage, down to γ~5, and a reasonable approximation even down to γ~2, though the solution is rigorous only for γ≫1. We examine the transition into the Blandford-McKee solution and the transition from the solution to the nonrelativistic self-similar Sedov-Taylor solution. These simulations demonstrate the attractive nature of the Blandford-McKee solution and its stability to radial perturbations.
Numerical simulations of stellar convective dynamos III. At the base of the convection zone

We describe numerical simulations of giant-cell solar convection and magnetic field generation. Nonlinear, three-dimensional, time-dependent solutions of the anelastic magnetohydrodynamic equations are presented for a stratified, rotating, spherical shell of ionized gas. The velocity, magnetic field, and thermodynamic variables are solved simultaneously and self-consistently with full nonlinear feedback. Convection, driven in the outer part of this shell by a superadiabatic gradient, penetrates into the inner, subadiabatic part. Previous dynamic dynamo sjmulations have demonstrated that, when the dynamo operates in the convection zone, the magnetic fields propagate away from the equator in the opposite direction inferred from the solar butterfly diagram. Our simulations suggest that the solar dynamo may be operating at the base of the convection zone in the transition region between the stable interior and the turbulent convective region. There our simulated angular velocity decreases with depth, as it does in the convection zone; but the simulated helicity has the opposite sign compared to its convection zone value. As a result, our simulated magnetic fields in this transition region initially propagated toward the equator. However, due to our limited numerical resolution of the small amplitude helical fluid motions in this dense, stable region, only the initial phase propagation could be simulated, not a complete magnetic cycle.
Mediation of Electronegative Low-Density Lipoprotein Signaling by LOX-1: A Possible Mechanism of Endothelial Apoptosis

The lectin-like oxidized LDL receptor LOX-1 mediates endothelial cell (EC) uptake of experimentally prepared copper-oxidized LDL (oxLDL). To confirm the atherogenic role of this receptor cloned against copper-oxLDL, we examined whether it mediates EC uptake of L5, an electronegative LDL abundant in dyslipidemic but not normolipidemic human plasma. Hypercholesterolemic (LDL-cholesterol, >160 mg/dL) human LDL was fractionated into L1–L5, increasingly electronegative, by ion-exchange chromatography. In cultured bovine aortic ECs (BAECs), L5 upregulated LOX-1 and induced apoptosis. Transfection of BAECs with LOX-1–specific small interfering RNAs (siLOX-1) minimized baseline LOX-1 production and restrained L5-induced LOX-1 upregulation. Internalization of labeled L1–L5 was monitored in BAECs and human umbilical venous ECs by fluorescence microscopy. LOX-1 knockdown with siLOX-1 impeded the endocytosis of L5 but not L1–L4. In contrast, blocking LDL receptor with RAP (LDL receptor–associated protein) stopped the internalization of L1–L4 but not L5. Although chemically different, L5 and oxLDL competed for EC entry through LOX-1. Via LOX-1, L5 signaling hampered Akt phosphorylation and suppressed EC expression of fibroblast growth factor-2 and Bcl-2. L5 also selectively inhibited Bcl-xL expression and endothelial nitric oxide synthase phosphorylation but increased synthesis of Bax, Bad, and tumor necrosis factor-&agr;. Blocking Akt phosphorylation with wortmannin increased LOX-1 expression, suggesting a modulatory role of Akt in LOX-1 synthesis; L5 upregulated LOX-1 by dephosphorylating Akt. Because endothelial nitric oxide synthase and Bcl-2 activities are Akt-dependent, L5 impairs Akt-mediated growth and survival signals in vascular ECs by way of LOX-1. Thus, the L5/LOX-1 complex may play a critical role in atherogenesis and illuminate important targets for disease intervention.
The Energetic Cost of Walking: A Comparison of Predictive Methods

Background The energy that animals devote to locomotion has been of intense interest to biologists for decades and two basic methodologies have emerged to predict locomotor energy expenditure: those based on metabolic and those based on mechanical energy. Metabolic energy approaches share the perspective that prediction of locomotor energy expenditure should be based on statistically significant proxies of metabolic function, while mechanical energy approaches, which derive from many different perspectives, focus on quantifying the energy of movement. Some controversy exists as to which mechanical perspective is “best”, but from first principles all mechanical methods should be equivalent if the inputs to the simulation are of similar quality. Our goals in this paper are 1) to establish the degree to which the various methods of calculating mechanical energy are correlated, and 2) to investigate to what degree the prediction methods explain the variation in energy expenditure. Methodology/Principal Findings We use modern humans as the model organism in this experiment because their data are readily attainable, but the methodology is appropriate for use in other species. Volumetric oxygen consumption and kinematic and kinetic data were collected on 8 adults while walking at their self-selected slow, normal and fast velocities. Using hierarchical statistical modeling via ordinary least squares and maximum likelihood techniques, the predictive ability of several metabolic and mechanical approaches were assessed. We found that all approaches are correlated and that the mechanical approaches explain similar amounts of the variation in metabolic energy expenditure. Most methods predict the variation within an individual well, but are poor at accounting for variation between individuals. Conclusion Our results indicate that the choice of predictive method is dependent on the question(s) of interest and the data available for use as inputs. Although we used modern humans as our model organism, these results can be extended to other species.
MAPK Signaling Pathway Regulates p27 Phosphorylation at Threonin 187 as Part of the Mechanism Triggered by Early-Weaning to Induce Cell Proliferation in Rat Gastric Mucosa

During rat postnatal development, gastric cell proliferation and differentiation depend on many elements, which include dietary pattern, hormones, growth factors and their signaling pathways. Among them, EGFR activity is increased through MAPK and Src cascades in response to early weaning that represents the abrupt transition from milk to solid food. We herein investigated the direct involvement of ERK pathway in the control of cell cycle progression during early weaning, and studied the specific role of p27. At 15 days, Wistar rats were separated from dams, fed with powdered chow and daily injected with PD98059 (MEK inhibitor, 300 µg/kg) or 0.5% DMSO (control). By using HE staining and immunohistochemistry for PCNA, we respectively detected mitotic (MI) and proliferative (PI) indices in 18-day-old pups, and observed that both were reduced by PD98059. As cell cycle-related proteins (cyclin E, CDK2, cyclin D1, CDK4, p21 and p27) are involved in proliferative regulation, we compared samples obtained at 17 days in the morning (17 d) and evening (17.5 d). We found that they were not altered after ERK inhibition, but cyclin D1, p21 and p27 levels changed throughout the day in the control group. As p27 activity depends on its integrity, we studied p27 phosphorylation (threonin 187), and observed that ERK inhibition reduced this process. We suggest that MAPK pathway interferes in the regulation of p27 function in the gastric mucosa during early weaning, possibly by controlling its degradation, and altogether this mechanism might contribute to the increase of epithelial proliferation at this condition.
Circadian Rhythm of Iguana Electroretinogram: The Role of Dopamine and Melatonin

The amplitude of the b-wave of the electroretinogram (ERG) varies with a circadian rhythm in the green iguana; the amplitude is high during the day (or subjective day) and low during the night (or subjective night). Dopamine and melatonin contents in the eye are robustly rhythmic under constant conditions; dopamine levels are high during the subjective day, and melatonin levels are high during the subjective night. Dopamine and melatonin affect the amplitude of the b-wave in an antagonistic and phase-dependent manner: dopamine D2-receptor agonists injected intraocularly during the subjective night produce high-amplitude b-waves characteristic of the subjective day, whereas melatonin injected intraocularly during the subjective day reduces b-wave amplitude. Sectioning the optic nerve abolishes the circadian rhythms of b-wave amplitude and of dopamine content. The results of this study suggest that in iguana, a negative feedback loop involving dopamine and melatonin regulates the circadian rhythm of the ERG b-wave amplitude that is at least in part generated in the brain.
Layoffs, Recall and the Duration of Unemployment

This paper shows that the prospect of recall to previous employer is important for a significant number of the unemployed in the United States and that taking into account the possibility of recalls has important implications for the study of unemployment spell durations. A job search model that allows for recalls is shown to lead naturally to a competing risks specification of the distribution of layoff unemployment spell durations in which recall and the taking of a new job are alternate routes for leaving unemployment. A large sample of individual layoff unemployment spell observations derived from the Panel Study of Income Dynamics is analyzed. The common finding for samples containing individuals with nonnegligible recall prospects of an escape rate from unemployment that declines with spell duration is shown to almost entirely result from a declining recall rate. The apparent declining recall rate may be indicative of important uncontrolled heterogeneity rather than true negative duration dependence. Strong positive duration dependence in the new job finding rate is uncovered for UI recipients. Factors raising the likelihood and value of recall appear to depress the new job finding rate. Substantial differences in the distribution of unemployment spell durations are found for UI recipients and nonrecipients. Large positive jumps in both the recall rate and new job finding rate are apparent around the point of UI benefits exhaustion for UI recipients. The results indicate that the potential duration of UI benefits plays an important role in the timing of recalls and of new job acceptances.
Call Attention to Rumors: Deep Attention Based Recurrent Neural Networks for Early Rumor Detection

The proliferation of social media in communication and information dissemination has made it an ideal platform for spreading rumors. Automatically debunking rumors at their stage of diffusion is known as \textit{early rumor detection}, which refers to dealing with sequential posts regarding disputed factual claims with certain variations and highly textual duplication over time. Thus, identifying trending rumors demands an efficient yet flexible model that is able to capture long-range dependencies among postings and produce distinct representations for the accurate early detection. However, it is a challenging task to apply conventional classification algorithms to rumor detection in earliness since they rely on hand-crafted features which require intensive manual efforts in the case of large amount of posts. This paper presents a deep attention model on the basis of recurrent neural networks (RNN) to learn \textit{selectively} temporal hidden representations of sequential posts for identifying rumors. The proposed model delves soft-attention into the recurrence to simultaneously pool out distinct features with particular focus and produce hidden representations that capture contextual variations of relevant posts over time. Extensive experiments on real datasets collected from social media websites demonstrate that (1) the deep attention based RNN model outperforms state-of-the-arts that rely on hand-crafted features; (2) the introduction of soft attention mechanism can effectively distill relevant parts to rumors from original posts in advance; (3) the proposed method detects rumors more quickly and accurately than competitors.
The GSM/UMTS Phone Number Catcher

For the individual privacy protection, the GSM system transmits the IMSI or TMSI number over the air instead of the phone number which will leak the identity of the users. The MSC, HLR/VLR will translate the IMSI/TMSI to the phone number in the core network. This paper proposed an idea about catching the GSM/UMTS Phone Number over the air by man-in-the-middle attack. The GSM/UMTS phone number catcher proposed in this paper was implemented on a pseudo base station with a mobile terminal which can transmit any frames we wanted. While the legal terminals are trying to access, the phone number catcher will relay all its frame to the operator's network and try to break the shared authentication key Ki. Then the system will get the phone number by pretending the legal terminal to call a designated phone. We will analyze the GSM protocol which is relevant to the phone number catcher and later present the performance of such a system by real tests and demonstrate its feasibility.
How does angiotensin AT2 receptor activation help neuronal differentiation and improve neuronal pathological situations?

The angiotensin type 2 (AT2) receptor of angiotensin II has long been thought to be limited to few tissues, with the primary effect of counteracting the angiotensin type 1 (AT1) receptor. Functional studies in neuronal cells have demonstrated AT2 receptor capability to modulate neuronal excitability, neurite elongation, and neuronal migration, suggesting that it may be an important regulator of brain functions. The observation that the AT2 receptor was expressed in brain areas implicated in learning and memory led to the hypothesis that it may also be implicated in cognitive functions. However, linking signaling pathways to physiological effects has always proven challenging since information relative to its physiological functions has mainly emerged from indirect observations, either from the blockade of the AT1 receptor or through the use of transgenic animals. From a mechanistic standpoint, the main intracellular pathways linked to AT2 receptor stimulation include modulation of phosphorylation by activation of kinases and phosphatases or the production of nitric oxide and cGMP, some of which are associated with the Gi-coupling protein. The receptor can also interact with other receptors, either G protein-coupled such as bradykinin, or growth factor receptors such as nerve growth factor or platelet-derived growth factor receptors. More recently, new advances have also led to identification of various partner proteins, thus providing new insights into this receptor’s mechanism of action. This review summarizes the recent advances regarding the signaling pathways induced by the AT2 receptor in neuronal cells, and discussed the potential therapeutic relevance of central actions of this enigmatic receptor. In particular, we highlight the possibility that selective AT2 receptor activation by non-peptide and selective agonists could represent new pharmacological tools that may help to improve impaired cognitive performance in Alzheimer’s disease and other neurological cognitive disorders.
Addition of rituximab to the CHOP regimen has no benefit in patients with primary extranodal diffuse large B-cell lymphoma

Background The addition of rituximab to cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) chemotherapy (R-CHOP) has significantly improved clinical outcomes for patients with diffuse large B-cell lymphoma (DLBCL). However, new predictors of patient response to R-CHOP have not been established. We aimed to evaluate the impact of R-CHOP compared with CHOP in patients with DLBCL and to establish clinical predictors of better outcomes in these patients. Methods We retrospectively identified 177 patients diagnosed with CD20-positive DLBCL and treated with CHOP (N=82) or R-CHOP (N=95). The response rate, event-free survival (EFS), and overall survival (OS) rates were compared between the 2 treatment groups. All patients were classified into primary extranodal lymphoma (PENL) or nodal lymphoma (NL) subgroups, and the clinical parameters of each subgroup were analyzed. Results The overall response rate was higher in R-CHOP group (95% vs. 84%, P=0.07). The 3-year EFS rate was significantly higher in R-CHOP group (71% vs. 52%, P=0.013), but the OS rate was comparable between the 2 groups (79% vs. 69%, P=0.23). A significant survival benefit was seen with R-CHOP compared to CHOP therapy in NL patients (P=0.002 for EFS and 0.04 for OS). Multivariate analyses confirmed that R-CHOP therapy is an independent prognostic factor for EFS (hazard ratio of 0.32 [0.17-0.62], P=0.001) and OS (hazard ratio of 0.4 [0.18-0.87], P=0.02) in NL patients. Conclusion Patients in the PENL group did not benefit from R-CHOP chemotherapy.
The Relationship between Subthreshold and Suprathreshold Ocular Dominance in Cat Primary Visual Cortex

Primary visual cortex (V1) is the site at which right and left eye pathways are first integrated, leading to a representation of the visual world in depth. The ocular dominance (OD) of individual cortical neurons varies and may be changed by altering visual experience during the developmental critical period. Estimates of OD, commonly used to quantify the right and left eye synaptic inputs, have previously been based on spike rate. Membrane potential (V m), however, is more closely related to the synaptic inputs onto neurons and should therefore more closely reflect the degree of input from the two eyes. To determine the relationship between OD based on membrane potential and on spike rate, intracellular recordings were made from visual cortical neurons. OD based on spike rate was systematically more monocular than OD based on membrane potential. The discrepancy between membrane-potential OD and spike-rate OD may be accounted for by a simple model of V m-to-spike-rate transformation.
CoGA: An R Package to Identify Differentially Co-Expressed Gene Sets by Analyzing the Graph Spectra

Gene set analysis aims to identify predefined sets of functionally related genes that are differentially expressed between two conditions. Although gene set analysis has been very successful, by incorporating biological knowledge about the gene sets and enhancing statistical power over gene-by-gene analyses, it does not take into account the correlation (association) structure among the genes. In this work, we present CoGA (Co-expression Graph Analyzer), an R package for the identification of groups of differentially associated genes between two phenotypes. The analysis is based on concepts of Information Theory applied to the spectral distributions of the gene co-expression graphs, such as the spectral entropy to measure the randomness of a graph structure and the Jensen-Shannon divergence to discriminate classes of graphs. The package also includes common measures to compare gene co-expression networks in terms of their structural properties, such as centrality, degree distribution, shortest path length, and clustering coefficient. Besides the structural analyses, CoGA also includes graphical interfaces for visual inspection of the networks, ranking of genes according to their “importance” in the network, and the standard differential expression analysis. We show by both simulation experiments and analyses of real data that the statistical tests performed by CoGA indeed control the rate of false positives and is able to identify differentially co-expressed genes that other methods failed.
Genetic Identification of a PilT Motor in Geobacter sulfurreducens Reveals a Role for Pilus Retraction in Extracellular Electron Transfer

The metal-reducing bacterium Geobacter sulfurreducens requires the expression of conductive pili to reduce iron oxides and to wire electroactive biofilms, but the role of pilus retraction in these functions has remained elusive. Here we show that of the four PilT proteins encoded in the genome of G. sulfurreducens, PilT3 powered pilus retraction in planktonic cells of a PilT-deficient strain of P. aeruginosa and restored the dense mutant biofilms to wild-type levels. Furthermore, PilT3 and PilT4 rescued the twitching motility defect of the PilT-deficient mutant. However, PilT4 was the only paralog whose inactivation in G. sulfurreducens lead to phenotypes associated with the hyperpiliation of non-retractile mutants such as enhanced adhesion and biofilm-forming abilities. In addition, PilT4 was required to reduce iron oxides. Taken together, the results indicate that PilT4 is the motor ATPase of G. sulfurreducens pili and reveal a previously unrecognized role for pilus retraction in extracellular electron transfer, a strategy that confers on Geobacter spp. an adaptive advantage for metal reduction in the natural environment.