Miracle-dz/UniFAR-FTUs huggingface dataset:
Subword-Based Tagging for Confidence-Dependent Chinese Word Segmentation

We proposed a subword-based tagging for Chinese word segmentation to improve the existing character-based tagging. The subword-based tagging was implemented using the maximum entropy (MaxEnt) and the conditional random fields (CRF) methods. We found that the proposed subword-based tagging outperformed the character-based tagging in all comparative experiments. In addition, we proposed a confidence measure approach to combine the results of a dictionary-based and a subword-tagging-based segmentation. This approach can produce an ideal tradeoff between the in-vocaulary rate and out-of-vocabulary rate. Our techniques were evaluated using the test data from Sighan Bakeoff 2005. We achieved higher F-scores than the best results in three of the four corpora: PKU(0.951), CITYU(0.950) and MSR(0.971).
The many faces of Crohn's Disease: Latest concepts in etiology

The notion that Crohn’s Disease (CD) occurs as a result of an aberrant reaction to the commensal microbiota in genetically susceptible hosts is widely regarded by physicians and scientists as fact. Yet although it is undisputed that Crohn’s Disease is immune-mediated, an aberrant reaction to one’s own native flora is far from proven. The aim of the current review is to present a summary of the known infectious causes of Crohn’s Disease, whilst highlighting the limitations of using outdated methods to attempt to classify the disease as a single entity. We propose a re-classification of Crohn’s Disease, and suggest that the disease is best conceptualized as a syndrome, an “umbrella-like” term comprising a group of diseases with varying infective etiologies, which clinically, endoscopically and histologically are indistinguishable from CD.
Visual Words for Automatic Lip-Reading

Lip reading is used to understand or interpret speech without hearing it, a technique especially mastered by people with hearing difficulties. The ability to lip read enables a person with a hearing impairment to communicate with others and to engage in social activities, which otherwise would be difficult. Recent advances in the fields of computer vision, pattern recognition, and signal processing has led to a growing interest in automating this challenging task of lip reading. Indeed, automating the human ability to lip read, a process referred to as visual speech recognition, could open the door for other novel applications. This thesis investigates various issues faced by an automated lip-reading system and proposes a novel "visual words" based approach to automatic lip reading. The proposed approach includes a novel automatic face localisation scheme and a lip localisation method.
Biped walking stabilization based on linear inverted pendulum tracking

A novel framework of biped walking stabilization control is introduced. The target robot is a 42 DOF humanoid robot HRP-4C which has a body dimensions close to the average Japanese female. We develop a body posture controller and foot force controllers on the joint position servo of the robot. By applying this posture/force control, we can regard the robot system as a simple linear inverted pendulum with ZMP delay. After a preliminary experiment to confirm the linear dynamics, we design a tracking controller for walking stabilization. It is evaluated in the experiments of HRP-4C walking and turning on a lab floor. The robot can also perform an outdoor walk on an uneven pavement.
Empirical Return Periods of the Most Intense Vapor Transports during Historical Atmospheric River Landfalls on the U.S. West Coast

Atmospheric rivers (ARs) come in all intensities, and clear communication of risks posed by individual storms in observations and forecasts can be a challenge. Modest ARs can be characterized by the percentile rank of their integrated water vapor transport (IVT) rates compared to past ARs. Stronger ARs can be categorized more clearly in terms of return periods or, equivalently, historical probabilities that at least one AR will exceed a given IVT threshold in any given year. Based on a 1980–2016 chronology of AR landfalls on the U.S. West Coast from NASA’s Modern-Era Retrospective Analysis for Research and Applications, version 2 (MERRA-2), datasets, the largest instantaneous IVTs—greater than 1700 kg m−1 s−1—have occurred in ARs making landfall between 41° and 46°N with return periods longer than 20 years. IVT values with similar return periods are smaller to the north and, especially, to the south (declining to ~750 kg m−1 s−1). The largest storm-sequence IVT totals have been centered near 42.5°N, with scatter among the top few events, and these large storm-sequence totals depend more on sequence duration than on the instantaneous IVT that went into them. Maximum instantaneous IVTs are largest in the Pacific Northwest in autumn, with largest IVT values arriving farther south as winter and spring unfold, until maximum IVTs reach Northern California in spring.
Infrared image correction for the reduction of background reflection

In infrared thermographic testing, a background reflection is one of the main causes of a false detection. The authors developed an image processing program that can reduce the effect of the background reflection from a thermal image. The program mainly consists of two parts. The first part is the correction of emissivity which depends on a face angle. The emissivity is changed not only by a material property and a surface roughness but also by a face angle. Especially in a test for a high building and a floating roof tank, the thermal image includes a wide range of face angle. In order to solve this problem, by using the theoretical equation of emissivity, the angle correction of emissivity is carried out for each pixel in the infrared image. It is confirmed that the first part of this program can correct efficiently the emissivity change for a flat plate and a curved surface which have a wide range of face angle respectively. The second part of the program is the reduction of a background reflection. The emissivity change causes the reflectivity change and, as a result, this changes the effect of the background reflection. To reduce this effect, the background heat source is measured separately and then is subtracted from the infrared image. At this time, the specular reflectivity should be used. Consequently, this program can reduce the effect of reflection from the background heat source and extract the radiation of the flaw part from the complex thermal image.
Pre-Invasive Ovarian Mucinous Tumors Are Characterized by CDKN2A and RAS Pathway Aberrations

Introduction: Mucinous tumors are the second most common form of epithelial ovarian tumor, yet the cell of origin for this histologic subtype remains undetermined. Although these tumors are thought to arise through a stepwise progression from benign cystadenoma to borderline tumor to invasive carcinoma, few studies have attempted to comprehensively characterize the genetic changes specific to this subtype or its precursors. Methods: To explore the spectrum of genomic alterations common to mucinous tumors we carried out high-resolution genome-wide copy number analysis, mutation screening by Sanger sequencing and immunohistochemistry on a series of primary ovarian mucinous cystadenomas (n = 20) and borderline tumors (n = 22). Results: Integration of copy number data, targeted mutation screening of RAS/RAF pathway members and immunohistochemistry reveals that p16 loss and RAS/RAF pathway alterations are highly recurrent events that occur early during mucinous tumor development. The frequency of concurrence of these events was observed in 40% of benign cystadenomas and 68% of borderline tumors. Conclusions: This study is the largest and highest resolution analysis of mucinous benign and borderline tumors carried out to date and provides strong support for these lesions being precursors of primary ovarian mucinous adenocarcinoma. The high level of uniformity in the molecular events underlying the pathogenesis of mucinous ovarian tumors provides an opportunity for treatments targeting specific mutations and pathways. Clin Cancer Res; 18(19); 5267–77. ©2012 AACR.
The extended evolutionary synthesis: its structure, assumptions and predictions

Scientific activities take place within the structured sets of ideas and assumptions that define a field and its practices. The conceptual framework of evolutionary biology emerged with the Modern Synthesis in the early twentieth century and has since expanded into a highly successful research program to explore the processes of diversification and adaptation. Nonetheless, the ability of that framework satisfactorily to accommodate the rapid advances in developmental biology, genomics and ecology has been questioned. We review some of these arguments, focusing on literatures (evo-devo, developmental plasticity, inclusive inheritance and niche construction) whose implications for evolution can be interpreted in two ways—one that preserves the internal structure of contemporary evolutionary theory and one that points towards an alternative conceptual framework. The latter, which we label the ‘extended evolutionary synthesis' (EES), retains the fundaments of evolutionary theory, but differs in its emphasis on the role of constructive processes in development and evolution, and reciprocal portrayals of causation. In the EES, developmental processes, operating through developmental bias, inclusive inheritance and niche construction, share responsibility for the direction and rate of evolution, the origin of character variation and organism–environment complementarity. We spell out the structure, core assumptions and novel predictions of the EES, and show how it can be deployed to stimulate and advance research in those fields that study or use evolutionary biology.
Internet-Based Cognitive Behavior Therapy vs. Cognitive Behavioral Group Therapy for Social Anxiety Disorder: A Randomized Controlled Non-inferiority Trial

Background and Aims Cognitive behavioral group therapy (CBGT) is an effective, well-established, but not widely available treatment for social anxiety disorder (SAD). Internet-based cognitive behavior therapy (ICBT) has the potential to increase availability and facilitate dissemination of therapeutic services for SAD. However, ICBT for SAD has not been directly compared with in-person treatments such as CBGT and few studies investigating ICBT have been conducted in clinical settings. Our aim was to investigate if ICBT is at least as effective as CBGT for SAD when treatments are delivered in a psychiatric setting. Methods We conducted a randomized controlled non-inferiority trial with allocation to ICBT (n = 64) or CBGT (n = 62) with blinded assessment immediately following treatment and six months post-treatment. Participants were 126 individuals with SAD who received CBGT or ICBT for a duration of 15 weeks. The Liebowitz Social Anxiety Scale (LSAS) was the main outcome measure. The following non-inferiority margin was set: following treatment, the lower bound of the 95 % confidence interval (CI) of the mean difference between groups should be less than 10 LSAS-points. Results Both groups made large improvements. At follow-up, 41 (64%) participants in the ICBT group were classified as responders (95% CI, 52%–76%). In the CBGT group, 28 participants (45%) responded to the treatment (95% CI, 33%–58%). At post-treatment and follow-up respectively, the 95 % CI of the LSAS mean difference was 0.68–17.66 (Cohen’s d between group = 0.41) and −2.51–15.69 (Cohen’s d between group = 0.36) favoring ICBT, which was well within the non-inferiority margin. Mixed effects models analyses showed no significant interaction effect for LSAS, indicating similar improvement across treatments (F = 1.58; df = 2, 219; p = .21). Conclusions ICBT delivered in a psychiatric setting can be as effective as CBGT in the treatment of SAD and could be used to increase availability to CBT. Trial Registration ClinicalTrials.gov NCT00564967
The Nuclear Dynamics of M32. I. Data and Stellar Kinematics

We have obtained optical long-slit spectroscopy of the nucleus of M32 using the Space Telescope Imaging Spectrograph aboard the Hubble Space Telescope. The stellar rotation velocity and velocity dispersion, as well as the full line-of-sight velocity distribution (LOSVD), were determined as a function of position along the slit using two independent spectral deconvolution algorithms. We see three clear kinematical signatures of the nuclear black hole: a sudden upturn, at ~0. ″3 from the center, in the stellar velocity dispersions; a flat or rising rotation curve into the center; and strong, non-Gaussian wings on the central LOSVD. The central velocity dispersion is ~130 km s-1 (Gaussian fit) or ≳175 km s-1 (corrected for the wings). The central kinematics are consistent with the presence of a supermassive compact object in M32 with a mass in the range × 106 M☉.
Run-time model checking of interaction and deontic models for multi-agent systems

This paper is concerned with the problem of obtaining predictable interactions between groups of agents in open environments when individual agents do not expose their BDI logic. The most popular approaches to this in practise have been to model interaction protocols and to model the deontic constraints imposed by individual agents. Both of these approaches are appropriate and necessary but their combination creates the practical problem of ensuring that interaction protocols come into contact with agents that possess compatible deontic constraints. This is essentially an issue of property checking dynamically at run-time. We show how model checking can be applied to this problem.
Linking Perceived Electronic Service Quality and Service Loyalty on the Dimensional Level: An Aspect of Multi-Channel Services

As the online buyer’s shopping patterns evolve using multiple channels in receiving and consuming products and services, electronic retailers are offering value-added services that facilitate and support the online shopping transaction and experience. Several eretailers adopted the strategy of logistical integration to offer their shoppers the ability to access physical outlets/touch-points to pickup and return their online purchase. Such deployment of physical outlets/touch-points to facilitate and support online transaction has been widely recognized as an important feature. Yet, it is not known how online shoppers perceive e-service quality in the presence of logistics integration services. More importantly, electronic markets are very competitive environments where the competitor is just a click away. Therefore, understanding the service loyalty in the context of virtual stores is essential for e-retailers’ survival. Several studies have found that superior eservice quality improves loyalty. However, most of these studies measured e-service quality and customer loyalty unidimensionally. The primary objective of this research is three-fold: (i) identifying the key dimensions of e-service quality; (ii) identifying the dimensions of e-service loyalty; (iii) examining the effects of the identified dimensions of e-service quality on the various types of customer loyalty. An empirical study resulted in developing three scales; the E-service-Qual scale for measuring e-service quality, the Int-Logis-Qual scale for measuring logistical integration quality and the E-loyalty scale for measuring customer loyalty. Our investigation revealed that assurance and reliability are the most important factors influencing both ‘preference loyalty’ and ‘loyalty under increased pricing’. Another striking finding is that responsiveness is the only factor that significantly affects ‘complaining behavior’. More importantly, we have found that facilitating online shopping by offering offline-pickup and offline-returns services improve securing the loyalty of existing customers. Both offline-returns and offlinepickup influence significantly ‘preference loyalty’, while offline-returns quality affects ‘loyalty under increased pricing’ indirectly mediated by the perception of assurance.
Myosin types and fiber types in cardiac muscle. I. Ventricular myocardium

Antisera against bovine atrial myosin were raised in rabbits, purified by affinity chromatography, and absorbed with insolubilized ventricular myosin. Specific anti-bovine atrial myosin (anti-bAm) antibodies reacted selectively with atrial myosin heavy chains, as determined by enzyme immunoassay combined with SDS-gel electrophoresis. In direct and indirect immunofluorescence assay, anti-bAm was found to stain all atrial muscle fibers and a minor proportion of ventricular muscle fibers in the right ventricle of the bovine heart. In contrast, almost all muscle fibers in the left ventricle were unreactive. Purkinje fibers showed variable reactivity. In the rabbit heart, all atrial muscle fibers were stained by anti-bAm, whereas ventricular fibers showed a variable response in both the right and left ventricle, with a tendency for reactive fibers to be more numerous in the right ventricle and in subepicardial regions. Diversification of fiber types with respect to anti-bAm reactivity was found to occur during late stages of postnatal development in the rabbit heart and to be influenced by thyroid hormone. All ventricular muscle fibers became strongly reactive after thyroxine treatment, whereas they became unreactive or poorly reactive after propylthiouracil treatment. These findings are consistent with the existence of different ventricular isomyosins whose relative proportions can vary according to the thyroid state. Variations in ventricular isomyosin composition can account for the changes in myosin Ca2+-activated ATPase activity previously observed in cardiac muscle from hyper- and hypothyroid animals and may be responsible for the changes in the velocity of contraction of ventricular myocardium that occur under these conditions. The differential distribution of ventricular isomyosins in the normal heart suggests that fiber types with different contractile properties may coexist in the ventricular myocardium.
14,15-Dihydroxy-eicosa-5(Z)-enoic Acid Selectively Inhibits 14,15-Epoxyeicosatrienoic Acid-Induced Relaxations in Bovine Coronary Arteries

Cytochrome P-450 epoxygenases metabolize arachidonic acid (AA) to epoxyeicosatrienoic acids (EETs). EETs relax vascular smooth muscle by membrane hyperpolarization. 14,15-Epoxyeicosa-5(Z)-enoic acid (14,15-EE5ZE) antagonizes many vascular actions of EETs. EETs are converted to the corresponding dihydroxyeicosatrienoic acids by soluble epoxide hydrolase (sEH). sEH activity in the bovine arterial endothelium and smooth muscle regulates endogenous EETs. This study examined sEH metabolism of 14,15-EE5ZE to 14,15-dihydroxy-eicosa-5(Z)-enoic acid (14,15-DHE5ZE) and the resultant consequences on EET relaxations of bovine coronary arteries (BCAs). BCAs converted 14,15-EE5ZE to 14,15-DHE5ZE. This conversion was blocked by the sEH inhibitor 12-(3-adamantan-1-yl-ureido)-dodecanoic acid (AUDA). 14,15-EET relaxations (maximal relaxation, 83.4 ± 4.5%) were inhibited by 14,15-DHE5ZE (10 μM; maximal relaxation, 36.1 ± 9.0%; p < 0.001). In sharp contrast with 14,15-EE5ZE, 14,15-DHE5ZE is a 14,15-EET-selective inhibitor and did not inhibit 5,6-, 8,9-, or 11,12-EET relaxations. 14,15-EET and 11,12-EET relaxations were similar in the presence and absence of AUDA (1 μM). 14,15-EE5ZE inhibited 14,15-EET relaxations to a similar extent with and without AUDA pretreatment. However, 14,15-EE5ZE inhibited 11,12-EET relaxations to a greater extent with than without AUDA pretreatment. These observations indicate that sEH converts 14,15-EE5ZE to 14,15-DHE5ZE, and this alteration influences antagonist selectivity against EET-regioisomers. 14,15-DHE5ZE inhibited endothelium-dependent relaxations to AA but not endothelium-independent relaxations to sodium nitroprusside. A series of sEH-resistant ether analogs of 14,15-EE5ZE was developed, and analogs with agonist and antagonist properties were identified. The present study indicates that conversion of 14,15-EE5ZE to 14,15-DHE5ZE produces a 14,15-EET-selective antagonist that will be a useful pharmacological tool to identify EET receptor(s) and EET function in the cardiovascular system.
Revising the Visualizer-Verbalizer Dimension: Evidence for Two Types of Visualizers

Sixty participants were administered spatial ability tests, a verbal ability test, and a visualizer-verbalizer cognitive style questionnaire. Although verbalizers tended to be a homogeneous group with an intermediate level of spatial ability, there were 2 groups of visualizers, 1 with high spatial ability (the spatial type) and another with low spatial ability (the iconic type). To compare the use of mental images by the 2 types of visualizers in solving problems, interviews with 8 high-spatial visualizers and 9 low-spatial visualizers were conducted. The students were presented with graphs of motion and were asked to visualize and interpret the motion of an object. Whereas low-spatial visualizers interpreted the graphs as pictures and mostly relied on visual (iconic) imagery, high-spatial visualizers constructed more schematic images and manipulated them spatially. In addition, we compared problem-solving strategies used by verbalizers to those of visualizers. In contrast to visualizers, verbalizers of low and high spatial ability did not have any clearly marked preference to use visual or spatial imagery.
How Does Political Instability Affect Economic Growth?

The purpose of this paper is to empirically determine the effects of political instability on economic growth. By using the system-GMM estimator for linear dynamic panel data models on a sample covering up to 169 countries, and 5-year periods from 1960 to 2004, we find that higher degrees of political instability are associated with lower growth rates of GDP per capita. Regarding the channels of transmission, we find that political instability adversely affects growth by lowering the rates of productivity growth and, to a smaller degree, physical and human capital accumulation. Finally, economic freedom and ethnic homogeneity are beneficial to growth, while democracy may have a small negative effect.
Novel antiplatelet agents in the prevention of cardiovascular complications – focus on ticagrelor

Atherothrombosis, thrombus formation as a result of atherosclerotic plaque rupture, is a major modern health problem, often underlying coronary artery disease, stroke, and peripheral arterial disease. After the treatment of an acute thrombotic episode, long-term therapy is warranted as a secondary prophylaxis of such events and their complications. Because of the importance of platelets’ involvement in the initiation and propagation of thrombosis, antiplatelet drugs have come to the forefront of atherothrombotic disease treatment. Dual antiplatelet therapy of aspirin plus clopidogrel – the current standard – has its benefits, but it also has its limitations with regard to its pharmacologic properties and adverse effects. For these reasons, within the last decade or so, the investigation of novel antiplatelet agents has prospered. Here, we review the main pathways through which platelets participate in acute thrombosis and the interruption of these pathways by using novel antiplatelet agents, including P2Y12 receptor antagonists (the recently approved prasugrel, the probable next-in-line ticagrelor, and others). The need for a more individualized patient therapy is evident; although most of the aforementioned pharmaceuticals have the potential to contribute to this, their clinical utility remains to be seen.