Miracle-dz/UniFAR-FTUs huggingface dataset:
The Self-Administered Patient Satisfaction Scale for Primary Hip and Knee Arthroplasty

Introduction. The objective of this study was to develop a short self-report questionnaire for evaluating patient satisfaction with the outcome of hip and knee replacement surgery. Methods. This scale consists of four items focusing on satisfaction with the extent of pain relief, improvement in ability to perform home or yard work, ability to perform recreational activities, and overall satisfaction with joint replacement. This instrument does not measure satisfaction with process of care. The responses are scored on a Likert scale, with the total score ranging from 25 to 100 per question. The instrument was tested on 1700 patients undergoing primary total hip and total knee replacement surgery, evaluated preoperatively, at 12 weeks, and one year postoperatively. Psychometric testing included internal consistency, measured with Cronbach's alpha, and convergent validity, measured by correlation with changes in measures of health status between the preoperative, 12-week, and one-year evaluations. Results. The internal consistency (reliability) of the scale, measured by the Cronbach's alpha, ranged from 0.86 to 0.92. The scale demonstrated substantial ceiling effects at 1 year. The scale scores correlated modestly with the absolute SF-36 PCS and WOMAC scores (ρ = 0.56–0.63 and also with the WOMAC change scores (ρ = 0.38–0.46) at both 12-week and 1-year followups. Conclusions. This instrument is valid and reliable for measuring patient satisfaction following primary hip and knee arthroplasty and could be further evaluated for use with other musculoskeletal interventions.
Subsidizing the Distribution Channel : Donor Funding to Improve the Availability of Products with Positive Externalities

January 2011 Abstract Large populations in the developing world lack adequate access to products, such as essential medicines, whose use confers positive externalities. Because of the critical role played by the privatesector distribution channel, donors (e.g., the Global Fund) are beginning to devote substantial resources to fund subsidies that encourage the channel to improve the availability of these products. A key question for a donor is whether it should subsidize the purchases or sales of the private channel. We find the answer depends crucially on whether consumers are homogeneous or heterogeneous in their valuation of the product. For the case of heterogeneous consumers’ valuations, we provide evidence that subsidizing sales leads to greater expected donor utility, consumption, and social welfare. When consumers’ valuations are homogeneous, we establish the opposite conclusion: subsidizing purchases leads to greater expected donor utility, consumption, and social welfare.
LBP − T OP based countermeasure against face spooﬁng attacks

User authentication is an important step to protect information and in this ﬁeld face biometrics is advantageous. Face biometrics is natural, easy to use and less human-invasive. Unfortunately, recent work has revealed that face biometrics is vulnerable to spooﬁng attacks using low-tech cheap equipments. This article presents a countermeasure against such attacks based on the LBP − TOP operator combining both space and time information into a single multiresolution texture descriptor. Experiments carried out with the REPLAY ATTACK database show a Half Total Error Rate ( HTER ) improvement from 15 . 16% to 7 . 60%.
DNA Methylation Profiling across the Spectrum of HPV-Associated Anal Squamous Neoplasia

Background Changes in host tumor genome DNA methylation patterns are among the molecular alterations associated with HPV-related carcinogenesis. However, there is little known about the epigenetic changes associated specifically with the development of anal squamous cell cancer (SCC). We sought to characterize broad methylation profiles across the spectrum of anal squamous neoplasia. Methodology/Principal Findings Twenty-nine formalin-fixed paraffin embedded samples from 24 patients were evaluated and included adjacent histologically normal anal mucosa (NM; n = 3), SCC-in situ (SCC-IS; n = 11) and invasive SCC (n = 15). Thirteen women and 11 men with a median age of 44 years (range 26–81) were included in the study. Using the SFP10 LiPA HPV-typing system, HPV was detected in at least one tissue from all patients with 93% (27/29) being positive for high-risk HPV types and 14 (93%) of 15 invasive SCC tissues testing positive for HPV 16. Bisulfite-modified DNA was interrogated for methylation at 1,505 CpG loci representing 807 genes using the Illumina GoldenGate Methylation Array. When comparing the progression from normal anal mucosa and SCC-IS to invasive SCC, 22 CpG loci representing 20 genes demonstrated significant differential methylation (p<0.01). The majority of differentially methylated gene targets occurred at or close to specific chromosomal locations such as previously described HPV methylation “hotspots” and viral integration sites. Conclusions We have identified a panel of differentially methlylated CpG loci across the spectrum of HPV-associated squamous neoplasia of the anus. To our knowledge, this is the first reported application of large-scale high throughput methylation analysis for the study of anal neoplasia. Our findings support further investigations into the role of host-genome methylation in HPV-associated anal carcinogenesis with implications towards enhanced diagnosis and screening strategies.
Growth pattern and differentiation of human soft tissue sarcomas in nude mice

Tumor suspensions prepared from 62 human soft tissue sarcomas were injected into the peritoneal cavity and subcutis of 124 nude mice. The sarcomas included were ten malignant fibrous histiocytomas, 15 fibrosarcomas, six tendosynovial sarcomas, five liposarcomas, nine myosarcomas, six angiosarcomas, six malignant schwannomas, and five miscellaneous sarcomas. Sixty‐two percent of the sarcomas showed progressive growth in nude mice either subcutaneously (46%), intraperitoneally (14%), or at both sites (40%). Fifty‐one percent of the primary sarcomas, 71% of the recurrent tumors, and 78% of the sarcomas that were metastatic grew in the animals. Sarcomas that were grafted into the subcutis appeared as solitary nodules and showed a more accelerated growth as well as better differentiation than those that were injected into the peritoneal cavity. The intraperitoneal tumors were multifocal and dedifferentiated growths. It appears that simultaneous subcutaneous and intraperitoneal grafting of human sarcomas into nude mice offers a model to study the histogenesis and morphologic variations of soft tissue sarcomas.
Determinants and outcomes of physical activity in patients with COPD: a systematic review

Background The relationship between physical activity, disease severity, health status and prognosis in patients with COPD has not been systematically assessed. Our aim was to identify and summarise studies assessing associations between physical activity and its determinants and/or outcomes in patients with COPD and to develop a conceptual model for physical activity in COPD. Methods We conducted a systematic search of four databases (Medline, Embase, CINAHL and Psychinfo) prior to November 2012. Teams of two reviewers independently selected articles, extracted data and used the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) to assess quality of evidence. Results 86 studies were included: 59 were focused on determinants, 23 on outcomes and 4 on both. Hyperinflation, exercise capacity, dyspnoea, previous exacerbations, gas exchange, systemic inflammation, quality of life and self-efficacy were consistently related to physical activity, but often based on cross-sectional studies and low-quality evidence. Results from studies of pharmacological and non-pharmacological treatments were inconsistent and the quality of evidence was low to very low. As outcomes, COPD exacerbations and mortality were consistently associated with low levels of physical activity based on moderate quality evidence. Physical activity was associated with other outcomes such as dyspnoea, health-related quality of life, exercise capacity and FEV1 but based on cross-sectional studies and low to very low quality evidence. Conclusions Physical activity level in COPD is consistently associated with mortality and exacerbations, but there is poor evidence about determinants of physical activity, including the impact of treatment.
miR-146a Attenuates Inflammatory Pathways Mediated by TLR4/NF-κB and TNFα to Protect Primary Human Retinal Microvascular Endothelial Cells Grown in High Glucose

Pathological mechanisms underlying diabetic retinopathy are still not completely understood. Increased understanding of potential cellular pathways responsive to hyperglycemia is essential to develop novel therapeutic strategies for diabetic retinopathy. A growing body of evidence shows that microRNA (miRNA) play important roles in pathological mechanisms involved in diabetic retinopathy, as well as possessing potential as novel therapeutic targets. The hypothesis of this study was that miR-146a plays a key role in attenuating hyperglycemia-induced inflammatory pathways through reduced TLR4/NF-κB and TNFα signaling in primary human retinal microvascular endothelial cells (REC). We cultured human REC in normal (5 mM) glucose or transferred to high glucose medium (25 mM) for 3 days. Transfection was performed on REC with miRNA mimic (hsa-miR-146a-5p). Our results demonstrate that miR-146a expression was decreased in human REC cultured in high glucose. Overexpression of miR-146a using mimics reduced the levels of TLR4/NF-κB and TNFα in REC cultured in high glucose. Both MyD88-dependent and -independent signaling were decreased by miR-146a overexpression in REC in high glucose conditions. The results suggest that miR-146a is a potential therapeutic target for reducing inflammation in REC through inhibition of TLR4/NF-κB and TNFα. Our study will contribute to understanding of diabetic retinal pathology, as well as providing important clues to develop therapeutics for clinical applications.
Kakeya-Nikodym averages and $L^p$-norms of eigenfunctions

We provide a necessary and sufficient condition that $L^p$-norms, $2<p<6$, of eigenfunctions of the square root of minus the Laplacian on 2-dimensional compact boundaryless Riemannian manifolds $M$ are small compared to a natural power of the eigenvalue $\lambda$. The condition that ensures this is that their $L^2$ norms over $O(\lambda^{-1/2})$ neighborhoods of arbitrary unit geodesics are small when $\lambda$ is large (which is not the case for the highest weight spherical harmonics on $S^2$ for instance). The proof exploits Gauss' lemma and the fact that the bilinear oscillatory integrals in H\"ormander's proof of the Carleson-Sj\"olin theorem become better and better behaved away from the diagonal. Our results are related to a recent work of Bourgain who showed that $L^2$ averages over geodesics of eigenfunctions are small compared to a natural power of the eigenvalue $\lambda$ provided that the $L^4(M)$ norms are similarly small. Our results imply that QUE cannot hold on a compact boundaryless Riemannian manifold $(M,g)$ of dimension two if $L^p$-norms are saturated for a given $2<p<6$. We also show that eigenfunctions cannot have a maximal rate of $L^2$-mass concentrating along unit portions of geodesics that are not smoothly closed.
The changing usage of a mature campus-wide wireless network

Wireless Local Area Networks (WLANs) are now commonplace on many academic and corporate campuses. As "Wi-Fi" technology becomes ubiquitous, it is increasingly important to understand trends in the usage of these networks.This paper analyzes an extensive network trace from a mature 802.11 WLAN, including more than 550 access points and 7000 users over seventeen weeks. We employ several measurement techniques, including syslogs, telephone records, SNMP polling and tcpdump packet sniffing. This is the largest WLAN study to date, and the first to look at a large, mature WLAN and consider geographic mobility. We compare this trace to a trace taken after the network's initial deployment two years ago.We found that the applications used on the WLAN changed dramatically. Initial WLAN usage was dominated by Web traffic; our new trace shows significant increases in peer-to-peer, streaming multimedia, and voice over IP (VoIP) traffic. On-campus traffic now exceeds off-campus traffic, a reversal of the situation at the WLAN's initial deployment. Our study indicates that VoIP has been used little on the wireless network thus far, and most VoIP calls are made on the wired network. Most calls last less than a minute.We saw greater heterogeneity in the types of clients used, with more embedded wireless devices such as PDAs and mobile VoIP clients. We define a new metric for mobility, the "session diameter. " We use this metric to show that embedded devices have different mobility characteristics than laptops, and travel further and roam to more access points. Overall, users were surprisingly non-mobile, with half remaining close to home about 98% of the time.
Neurobiology Evidence for hearing loss in amblyopsid cavefishes

The constant darkness of caves and other subterranean habitats imposes sensory constraints that offer a unique opportunity to examine evolution of sensory modalities. Hearing in cavefishes has not been well explored, and here we show that cavefishes in the family Amblyopsidae are not only blind but have also lost a significant portion of their hearing range. Our results showed that cave and surface amblyopsids shared the same audiogram profile at low frequencies but only surface amblyopsids were able to hear frequencies higher than 800 Hz and up to 2 kHz. We measured ambient noise in aquatic cave and surface habitats and found high intensity peaks near 1 kHz for streams underground, suggesting no adaptive advantage in hearing in those frequencies. In addition, cave amblyopsids had lower hair cell densities compared with their surface relative. These traits may have evolved in response to the loud high-frequency background noise found in subterranean pools and streams. This study represents the first report of auditory regression in a subterranean organism.
The FAME Speech-to-Speech Translation System for Catalan, English, and Spanish

This paper describes the evaluation of the FAME interlingua-based speech-to-speech translation system for Catalan, English and Spanish. This system is an extension of the already existing NESPOLE! that translates between English, French, German and Italian. This article begins with a brief introduction followed by a description of the system architecture and the components of the translation module including the Speech Recognizer, the analysis chain, the generation chain and the Speech Synthesizer. Then we explain the interlingua formalism used, called Interchange Format (IF). We show the results obtained from the evaluation of the system and we describe the three types of evaluation done. We also compare the results of our system with those obtained by a stochastic translator which has been independently developed over the course of the FAME project. Finally, we conclude with future work.
Multi-walled carbon nanotubes suppress potassium channel activities in PC12 cells

The advancement in nanotechnology has produced technological and conceptual breakthroughs but the effects nanomaterials have on organisms at the cellular level are poorly understood. Here we report that carboxyl-terminated multi-walled carbon nanotubes (MWCNTs) act as antagonists of three types of potassium channels as assessed by whole-cell patch clamp electrophysiology on undifferentiated pheochromocytoma (PC12) cells. Our results showed that carboxyl-terminated MWCNTs suppress the current densities of Ito, IK and IK1 in a time-dependent and irreversible manner. The suppressions were most distinct 24 h after incubation with MWCNTs. However, MWCNTs did not significantly change the expression levels of reactive oxygen species (ROS) or intracellular free calcium and also did not alter the mitochondrial membrane potential (ΔΨm) in PC12 cells. These results suggest that oxidative stress was not involved in the MWCNTs suppression of Ito, IK and IK1 current densities. Nonetheless, the suppression of potassium currents by MWCNTs will impact on electrical signaling of excitable cells such as neurons and muscles.
Prior knowledge for time domain quantification of in vivo brain or liver 31P MR spectra

Prior knowledge is required when quantifying in vivo 31P magnetic resonance spectra from the brain or liver. The prior knowledge system we have used models both the phosphomonoester and phosphodiester resonances as two peaks of equal linewidth and fixed relative chemical shift. The analysis of the data is carried out in the time domain, which allows the broad component of the spectra to be modelled. This prior knowledge method has been tested for analysis of in vivo 31P MR spectra from the liver and brain and gives results consistent with other methods that are also used to analyse the spectra, but with reduced variability. This technique may be utilized for studies requiring serial MR spectroscopy examinations, before and after patient treatment. Copyright © 2003 John Wiley & Sons, Ltd.
How to Evaluate Foreground Maps

The output of many algorithms in computer-vision is either non-binary maps or binary maps (e.g., salient object detection and object segmentation). Several measures have been suggested to evaluate the accuracy of these foreground maps. In this paper, we show that the most commonly-used measures for evaluating both non-binary maps and binary maps do not always provide a reliable evaluation. This includes the Area-Under-the-Curve measure, the Average-Precision measure, the Fβ-measure, and the evaluation measure of the PASCAL VOC segmentation challenge. We start by identifying three causes of inaccurate evaluation. We then propose a new measure that amends these flaws. An appealing property of our measure is being an intuitive generalization of the Fβ-measure. Finally we propose four meta-measures to compare the adequacy of evaluation measures. We show via experiments that our novel measure is preferable.
Effects of Newspaper Coverage on Public Knowledge About Modifiable Cancer Risks

This study explores the relationship between cancer newspaper coverage and public knowledge about cancer prevention, confirming self-reported associations between news exposure and cancer prevention knowledge with descriptions of newspaper coverage of modifiable cancer risks. Content analyses (N = 954) revealed that newspapers pay relatively little attention to cancer prevention. However, there is greater newspaper attention to tobacco and diet than to exercise, sun, and alcohol. Survey analysis (the National Cancer Institute's Health Information National Trends Survey) revealed that after controlling for differences based on gender, race, age, income, and education, attention to health news was significantly associated with knowledge about cancer risks associated with food and smoking but not for knowledge about exercise, sun, or alcohol. These findings conform to the findings of the content analysis data and provide a validation of a self-reported measure of media exposure, as well as evidence suggesting a threshold below which news coverage may not generate public knowledge about cancer prevention.
A New Fault Diagnosis Method and a Fault-Tolerant Switching Strategy for Matrix Converters Operating With Optimum Alesina-Venturini Modulation

This paper presents a new diagnostic technique for the diagnosis of open-circuit faults in matrix converters operating with an Optimum Alesina-Venturini modulation scheme. Compared to previous diagnostic techniques developed for matrix converters, the technique proposed in this paper has the major advantage of not requiring the installation of any additional sensors in the converter besides the ones already present for control purposes. Hence, it can be easily integrated into the control platform of the converter at no additional cost. In addition to the diagnostic approach, a new fault-tolerant switching strategy is also presented so that after the appearance of an open-circuit fault, the matrix converter can continue to run although with degraded performance, until a repair action can be taken. Several simulation and experimental results are presented, demonstrating the effectiveness and applicability of the developed techniques.
Prevention of Parent to Child Transmission of HIV: Single Centre Experience of 14 years at Tertiary Care Hospital in Delhi, India.

INTRODUCTION Prevention of Parent To Child Transmission (PPTCT) of HIV/AIDS is an integral component of AIDS control programme. PPTCT is an ongoing programme since last 15 years. AIM The aim of the study was to evaluate the reduction in the burden of disease in newborn and infants by prevention of parents to child transmission of HIV/AIDS. MATERIALS AND METHODS This retrospective study was conducted at Department of Obstetrics and Gynecology in a tertiary care hospital of Delhi from May 2002 to May 2015. The data was collected from records of maternal details registered at PPTCT clinic as well as list of infants undergoing Early Infant Diagnosis (EID) recorded in the standard format as per instructions from National AIDS Control Organization (NACO) of India. The Programme performance was assessed against performance indicators stated by NACO, India. RESULTS Evaluation was done by dividing study period into two halves of seven years each. Out of 2,52,447 new antenatal case registration, overall, 43% received pretest of which, 91% were tested. Antenatal seropositivity rate varied from 0.1%-0.25%. Of 243 seropositive antenatal women 187 partners tested positive. While 25 women opted for MTP, 15 had still births. There were 17 neonatal deaths at 3-12 months attributable to respiratory infections and diarrheal diseases. Operative delivery rates declined from 50% to 31% over the years. Most women opted for breast feeding. The lost to follow up rate of newborns was quite high with details of only 43.5% being available at 18 months of infant's age. A total of three infants tested HIV positive at 18 months of age. CONCLUSION The study highlights the practical aspects of policy implementation and operational issues involved in low resource country.
Similarity-based Learning via Data Driven Embeddings

We consider the problem of classification using similarity/distance functions over data. Specifically, we propose a framework for defining the goodness of a (dis)similarity function with respect to a given learning task and propose algorithms that have guaranteed generalization properties when working with such good functions. Our framework unifies and generalizes the frameworks proposed by [1] and [2]. An attractive feature of our framework is its adaptability to data - we do not promote a fixed notion of goodness but rather let data dictate it. We show, by giving theoretical guarantees that the goodness criterion best suited to a problem can itself be learned which makes our approach applicable to a variety of domains and problems. We propose a landmarking-based approach to obtaining a classifier from such learned goodness criteria. We then provide a novel diversity based heuristic to perform task-driven selection of landmark points instead of random selection. We demonstrate the effectiveness of our goodness criteria learning method as well as the landmark selection heuristic on a variety of similarity-based learning datasets and benchmark UCI datasets on which our method consistently outperforms existing approaches by a significant margin.