Miracle-dz/UniFAR-FTUs huggingface dataset:
Pathogenesis and neuroimaging of cerebral large and small vessel disease in type 2 diabetes: A possible link between cerebral and retinal microvascular abnormalities

Diabetes patients have more than double the risk of ischemic stroke compared with non‐diabetic individuals, and its neuroimaging characteristics have important clinical implications. To understand the pathophysiology of ischemic stroke in diabetes, it is important to focus not only on the stroke subtype, but also on the size and location of the occlusive vessels. Specifically, ischemic stroke in diabetes patients might be attributed to both large and small vessels, and intracranial internal carotid artery disease and small infarcts of the posterior circulation often occur. An additional feature is that asymptomatic lacunar infarctions are often seen in the basal ganglia and brain stem on brain magnetic resonance imaging. In particular, cerebral small vessel disease (SVD), including lacunar infarctions, white matter lesions and cerebral microbleeds, has been shown to be associated not only with stroke incidence, but also with the development and progression of dementia and diabetic microangiopathy. However, the pathogenesis of cerebral SVD is not fully understood. In addition, data on the association between neuroimaging findings of the cerebral SVD and diabetes are limited. Recently, the clinical importance of the link between cerebral SVD and retinal microvascular abnormalities has been a topic of considerable interest. Several clinical studies have shown that retinal microvascular abnormalities are closely related to cerebral SVD, suggesting that retinal microvascular abnormalities might be pathophysiologically linked to ischemic cerebral SVD. We review the literature relating to the pathophysiology and neuroimaging of cerebrovascular disease in diabetes, and discuss the problems based on the concept of cerebral large and small vessel disease.
A Review of Family-Based Tests for Linkage Disequilibrium between a Quantitative Trait and a Genetic Marker

Quantitative trait transmission/disequilibrium tests (quantitative TDTs) are commonly used in family-based genetic association studies of quantitative traits. Despite the availability of various quantitative TDTs, some users are not aware of the properties of these tests and the relationships between them. This review aims at outlining the broad features of the various quantitative TDT procedures carried out in the frequently used QTDT and FBAT packages. Specifically, we discuss the “Rabinowitz” and the “Monks-Kaplan” procedures, as well as the various “Abecasis” and “Allison” regression-based procedures. We focus on the models assumed in these tests and the relationships between them. Moreover, we discuss what hypotheses are tested by the various quantitative TDTs, what testing procedures are best suited to various forms of data, and whether the regression-based tests overcome population stratification problems. Finally, we comment on power considerations in the choice of the test to be used. We hope this brief review will shed light on the similarities and differences of the various quantitative TDTs.
Under Voltage Load Shedding Scheme Using Meta-heuristic Optimization Methods

Load shedding has been extensively studied because of multiple power system failure occurrences worldwide. Reliable techniques are required to provide rapid and precise load shedding to avert voltage collapse in power networks. Meta-heuristic optimization approaches are currently the widely developed methods because of their robustness and flexibility in dealing with complex and non-linear systems. These methods include genetic algorithm, fuzzy logic control, particle swarm optimization, artificial neural network, ant colony optimization, big-bang big-crunch optimization, and many others. This study provides an overview of all the meta-heuristic methods implemented for under voltage load shedding in power systems.
High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities

Microbes in soils and other environments produce extracellular enzymes to depolymerize and hydrolyze organic macromolecules so that they can be assimilated for energy and nutrients. Measuring soil microbial enzyme activity is crucial in understanding soil ecosystem functional dynamics. The general concept of the fluorescence enzyme assay is that synthetic C-, N-, or P-rich substrates bound with a fluorescent dye are added to soil samples. When intact, the labeled substrates do not fluoresce. Enzyme activity is measured as the increase in fluorescence as the fluorescent dyes are cleaved from their substrates, which allows them to fluoresce. Enzyme measurements can be expressed in units of molarity or activity. To perform this assay, soil slurries are prepared by combining soil with a pH buffer. The pH buffer (typically a 50 mM sodium acetate or 50 mM Tris buffer), is chosen for the buffer's particular acid dissociation constant (pKa) to best match the soil sample pH. The soil slurries are inoculated with a nonlimiting amount of fluorescently labeled (i.e. C-, N-, or P-rich) substrate. Using soil slurries in the assay serves to minimize limitations on enzyme and substrate diffusion. Therefore, this assay controls for differences in substrate limitation, diffusion rates, and soil pH conditions; thus detecting potential enzyme activity rates as a function of the difference in enzyme concentrations (per sample). Fluorescence enzyme assays are typically more sensitive than spectrophotometric (i.e. colorimetric) assays, but can suffer from interference caused by impurities and the instability of many fluorescent compounds when exposed to light; so caution is required when handling fluorescent substrates. Likewise, this method only assesses potential enzyme activities under laboratory conditions when substrates are not limiting. Caution should be used when interpreting the data representing cross-site comparisons with differing temperatures or soil types, as in situ soil type and temperature can influence enzyme kinetics.
The Role of Parietal Cortex in Verbal Working Memory

Neuroimaging studies of normal subjects and studies of patients with focal lesions implicate regions of parietal cortex in verbal working memory (VWM), yet the precise role of parietal cortex in VWM remains unclear. Some evidence (Paulesu et al., 1993; Awh et al., 1996) suggests that the parietal cortex mediates the storage of verbal information, but these studies and most previous ones included encoding and retrieval processes as well as storage and rehearsal of verbal information. A recent positron emission tomography (PET) study by Fiez et al. (1996) isolated storage and rehearsal from other VWM processes and did not find reliable activation in parietal cortex. This result suggests that parietal cortex may not be involved in VWM storage, contrary to previous proposals. However, we report two behavioral studies indicating that some of the verbal material used by Fiez et al. (1996) may not have required phonological representations in VWM. In addition, we report a PET study that isolated VWM encoding, retrieval, and storage and rehearsal processes in different PET scans and used material likely to require phonological codes in VWM. After subtraction of appropriate controls, the encoding condition revealed no reliable activations; the retrieval condition revealed reliable activations in dorsolateral prefrontal, anterior cingulate, posterior parietal, and extrastriate cortices, and the storage condition revealed reliable activations in dorsolateral prefrontal, inferior frontal, premotor, and posterior parietal cortices, as well as cerebellum. These results suggest that parietal regions are part of a network of brain areas that mediate the short-term storage and retrieval of phonologically coded verbal material.
Selective Attention and Perceptual Load in Autism Spectrum Disorder

It has been suggested that the locus of selective attention (early vs. late in processing) is dependent on the perceptual load of the task. When perceptual load is low, irrelevant distractors are processed (late selection), whereas when perceptual load is high, distractor interference disappears (early selection). Attentional abnormalities have long been reported within autism spectrum disorder (ASD), and this study is the first to examine the effect of perceptual load on selective attention in this population. Fourteen adults with ASD and 23 adults without ASD performed a selective attention task with varying perceptual loads. Compared with the non-ASD group, the ASD group required higher levels of perceptual load to successfully ignore irrelevant distractors; moreover, the ASD group did not show any general reduction in performance speed or accuracy. These results suggest enhanced perceptual capacity in the ASD group and are consistent with previous observations regarding superior visual search abilities among individuals with ASD.
Determinants of Capital Budgeting Methods and Hurdle Rates in Nordic Firms

We study the determinants for the choice of capital budgeting methods and the setting of hurdle rates (WACCs) in five Nordic countries. Combining survey data with a rich set of determinants, including ownership data, CFO characteristics, and financial data, we find that the use of the Net Present Value method and the sophistication of the capital budgeting are related to firm characteristics, variables proxying for real option features in investments and CFO characteristics (age and education). We also find support for significantly higher hurdle rates than motivated by economic theory. The premium is weakly positively related to managerial short-term pressure and strongly negatively related to the sophistication level of the firm’s capital budgeting.
Identification and Characterization of microRNAs from Peanut (Arachis hypogaea L.) by High-Throughput Sequencing

Background MicroRNAs (miRNAs) are noncoding RNAs of approximately 21 nt that regulate gene expression in plants post-transcriptionally by endonucleolytic cleavage or translational inhibition. miRNAs play essential roles in numerous developmental and physiological processes and many of them are conserved across species. Extensive studies of miRNAs have been done in a few model plants; however, less is known about the diversity of these regulatory RNAs in peanut (Arachis hypogaea L.), one of the most important oilseed crops cultivated worldwide. Results A library of small RNA from peanut was constructed for deep sequencing. In addition to 126 known miRNAs from 33 families, 25 novel peanut miRNAs were identified. The miRNA* sequences of four novel miRNAs were discovered, providing additional evidence for the existence of miRNAs. Twenty of the novel miRNAs were considered to be species-specific because no homolog has been found for other plant species. qRT-PCR was used to analyze the expression of seven miRNAs in different tissues and in seed at different developmental stages and some showed tissue- and/or growth stage-specific expression. Furthermore, potential targets of these putative miRNAs were predicted on the basis of the sequence homology search. Conclusions We have identified large numbers of miRNAs and their related target genes through deep sequencing of a small RNA library. This study of the identification and characterization of miRNAs in peanut can initiate further study on peanut miRNA regulation mechanisms, and help toward a greater understanding of the important roles of miRNAs in peanut.
The impact of human immunodeficiency virus infection on cervical preinvasive and invasive neoplasia in South Africa

Objectives: Sub-Saharan Africa is at the epicentre of the human immunodeficiency virus (HIV) epidemic and has the highest incidence of invasive cervical cancer (ICC) in the world. Access to highly active antiretroviral treatment (HAART) in South Africa is still limited and provided only to nonpregnant women with a CD4+ T-cell count <200 μg/L. We evaluated the relative distribution of cervical preinvasive and invasive neoplasia among HIV-infected (treated or not) and uninfected women in the Limpopo Province of South Africa. Methods: We compared the consecutive biopsy-diagnosed cervical pathology of 1,023 HIV-infected and 1,023 uninfected women. We investigated the influence of the CD4+ T-cell count and of HAART on the relative distribution of cervical pathology. Results: There was a significantly higher proportion of cervical intraepithelial neoplasia (CIN)1 (P = 0.012) and 2 (P = 0.01) but a lower proportion of ICC (P = 0.015) among HIV-infected women. Patients on HAART had less CIN1 (P = 0.018), 2 (P = 0.18) and ICC (P = 0.019) that their untreated counterparts. The mean CD4 count was similar regardless of cervical lesions and HAART or no treatment. Conclusion: Our data support the concept that HIV-infected women exhibit a higher rate of high-grade preinvasive lesions than uninfected controls. However, they have a significantly lower rate of ICC as compared with uninfected counterparts. The inclusion of ICC among acquired immune deficiency syndrome-defining illnesses is questionable.
The Role of Servant Leadership in Developing an Ethical Climate in Sport Organizations

Evaluation of leadership as a necessary component to reform sport could be critical to fostering a more ethical climate and reducing the frequency and severity of ethical improprieties within this context. However, limited research has examined the relationship between leadership and ethical climate. Servant leadership, due to its ethical component and people-centered focus, is a leadership approach that may best support development of an ethical climate. The purpose of this study was to explore the influence of servant leadership on perceptions of an ethical climate in intercollegiate athletic departments, with an examination of how trust and perceptions of organizational justice indirectly influence the relationship between servant leadership and perceptions of an ethical climate. Findings indicated that servant leadership was directly related to trust in leadership and perceptions of an ethical climate. Further, both trust in the leader and procedural justice indirectly influenced the relationship betw.
Asymmetric Caregiving by Grandparents, Aunts, and Uncles and the Theories of Kin Selection and Paternity Certainty: How Does Evolution Explain Human Behavior Toward Close Relatives?

Evolutionary theories explain altruism between related individuals, not only for nonhuman animals but also humans themselves. In sociobiology and evolutionary psychology, the supposedly universally found stronger matrilineal kin caregiving by grandparents, aunts, and uncles is often explained by paternity uncertainty in the male descent line. The present article provides an overview of theories and results of the evolutionary research. I will focus, in particular, on the universal caregiving pattern as well as on cultural variety in kin caregiving, the role of actual paternity certainty in the society, theoretical inconsistencies, and nonconsanguineous step relationships. From the analysis of the empirical data, I will conclude that the paternity certainty hypothesis is in fact not a very suitable explanation for the asymmetric kin caregiving found in humans. I will discuss how human behavior toward relatives, in particular grandchildren, can be alternatively explained from an evolutionary perspective.
Number and Locations of Agonist Binding Sites Required to Activate Homomeric Cys-Loop Receptors

Homo-pentameric Cys-loop receptors contain five identical agonist binding sites, each formed at a subunit interface. To determine the number and locations of binding sites required to generate a stable active state, we constructed a receptor subunit with a mutation that disables the agonist binding site and a reporter mutation that alters unitary conductance and coexpressed mutant and nonmutant subunits. Although receptors with a range of different subunit compositions are produced, patch-clamp recordings reveal that the amplitude of each single-channel opening event reports the number and, for certain subunit combinations, the locations of subunits with intact binding sites. We find that receptors with three binding sites at nonconsecutive subunit interfaces exhibit maximal mean channel open time, receptors with binding sites at three consecutive or two nonconsecutive interfaces exhibit intermediate open time, and receptors with binding sites at two consecutive or one interface exhibit brief open time. Macroscopic recordings after rapid application of agonist reveal that channel activation slows and the extent of desensitization decreases as the number of binding sites per receptor decreases. The overall results provide a framework for defining mechanisms of activation and drug modulation for homo-pentameric Cys-loop receptors.
A Framework for Open Assurance of Learning

Assurance of Learning (AOL) refers to the outcomes assessment process which involves the systematic collection, review, and use of information about educational programs undertaken for the purpose of improving student learning and development [8]. While emerging trends such as open education, open learning, learning analytics, academic analytics, and big data in education have recently become mainstream, studies regarding the design and development of open source analytics applications for AOL are non-existent. In this paper, we describe an application called AOL Analyzer that we developed for our business school last year to assist in the analysis of AOL results reported by faculty. To the best of our knowledge, this is a first paper to bridge the existing gap in AOL analytics research.
Not in Our Genes: Biology, Ideology and Human Nature R. C. Lewontin, Steve Rose, and Leon J. Kamin New York: Pantheon Books, 1984

PrtJcis. Not In Our Genes is an unabashedly polemical work. At the beginning, the authors explicitly state their opposition to "the oppressive forms in which [biological] determinist ideology manifests itself" (p. ix). Their goal is to aid in the creation of "a more socially just-a socialist-society" (p. ix). In the first chapter they deal with the contemporary rise of the New Right and the place of biological determinism in this ideology. As an alternative, they propose a dia- lectical approach to the understanding of human social behavior. The subsequent two chapters trace the history and explore the political nature of the ideas of biological determinism and tie these to the rise of bourgeois society. Chapter 4 begins with a discussion of politi- cal and economic inequality and then introduces the contradictions in the three basic claims of biological determinism: (1) inequalities in society are due to differences in intrinsic merit and ability; (2) this is largely due to genetic differences; and (3) the result is the inevitable creation of hierarchical societies. The following chapters deal with the controversy over I.Q. testing, the persistence of patriarchy, the political uses of psychiatry, the controversy over the causes and nature of schizophrenia, and the advent of soci- obiological explanations of social behavior. The final chapter tries to posit a better approach to the issue, based on the assertion that there is no social behavior that is built into our genes in such a way that it cannot be and shaped by social conditioning" They extreme cultural determinism as its biological bedfellow" Thus, of the behavior of organisms. • are both social and biological" are all amenable to analysis many
Cholinergic and Anatomical Dissociation of the Engagement and Disengagement of Spatial Attention in Rats

The spatial allocation of attention is a fundamental process that allows us to detect relevant behavioural stimuli, and involves both the engagement and disengagement of attention. The prefrontal (PFC) and posterior parietal (PPC) cortical regions have been identified as central nodes in a network for allocation of spatial attention. Additionally, these regions are modulated by the neurochemical acetylcholine. In this thesis, I investigated the neural underpinnings of engaging and disengaging spatial attention in rats, with a focus on the role of cholinergic input into the neocortex, including the PFC and the PPC. In the first experiment (Chapter 3), local field potentials in both the PFC and PPC, during the 5-choice serial reaction time task (5CSRTT), were modulated by cholinergic cortical deafferentation. Specifically, successful target detection was associated with increased PFC-PPC coherence in the beta frequency during the preparatory pre-target period and with the increase in the PPC beta power. Both of these neural responses were attenuated after cholinergic deafferentation of the neocortex, which was also
Deep pressure therapy (DPT) use in the reduction of challenging behaviors for an individual with autism spectrum disorder and intellectual disability

Sensory integration therapy (SIT) has been used as an intervention for sensory sensitivities in individuals with autism spectrum disorder (ASD) for decades without clear empirical evidence of its efficacy. Recent research has supported the use of deep pressure therapy (DPT) when applied in varying degrees to the upper body. The T.Jacket (an app-driven vest with air bladders and pump) is an emerging and novel approach to DPT. This single-subject study examined the effects of the T.Jacket on off-task behavior and challenging behaviors in an individual adolescent with ASD, speech impairment, and intellectual disability. Experimental control was not established across all settings and phases for off-task behavior and challenging behaviors. Rationale is given for future research in an area of symptoms recently recognized in the DSM-5 (i.e., hyper- or hyporeactivity to sensory input) for ASD yet has little to no empirically based intervention.
Body mass index can similarly predict the presence of multiple cardiovascular risk factors in middle-aged Japanese subjects as waist circumference.

OBJECTIVE Adiposity is closely associated with the clustering of metabolic risk factors such as high blood pressure, dyslipidemia, and glucose intolerance. Waist circumference and body mass index (BMI) are the established markers of abdominal adiposity and general adiposity, respectively. However, it has not been examined whether these two markers can detect the clustering of metabolic risk factors in Japanese subjects. METHODS AND RESULTS We studied 5,796 Japanese middle-aged subjects aged 40-60 years (4,344 males and 1,452 females). Metabolic risk factors including high blood pressure, dyslipidemia, and glucose intolerance were identified according to the diagnostic criteria for metabolic syndrome in Japan. The number of metabolic risk factors was significantly associated with the BMI values in both male and female subjects. The prevalence of subjects with multiple (two or more) metabolic risk factors was 29.4% and 7.6% in males and females, respectively. According to receiver operating characteristic (ROC) analysis, the area under curve values of BMI and waist circumference did not differ in male (0.658 vs. 0.671, p=n.s.) and female (0.776 vs. 0.790, p=n.s.) subjects, indicating that the waist circumference as well as the BMI could be useful in detecting the occurrence of multiple metabolic risk factors. The appropriate cut-off values of BMI to predict the presence of multiple metabolic risk factors were 24.7 and 23.4 kg/m(2) in males and females, respectively. The sensitivity and specificity using these cut-off values were 58 and 65% in males and 65 and 77% in females, respectively. CONCLUSION The BMI values can similarly predict the presence of multiple metabolic risk factors just as the waist circumference in Japanese middle-aged subjects.