Miracle-dz/UniFAR-FTUs huggingface dataset:
Has Adolescent Suicidality Decreased in the United States? Data From Two National Samples of Adolescents Interviewed in 1995 and 2005

We compared the prevalence and correlates of adolescent suicidal ideation and attempts in two nationally representative probability samples of adolescents interviewed in 1995 (National Survey of Adolescents; N = 4,023) and 2005 (National Survey of Adolescents-Replication; N = 3,614). Participants in both samples completed a telephone survey that assessed major depressive episode (MDE), post-traumatic stress disorder, suicidal ideation and attempts, violence exposure, and substance use. Results demonstrated that the lifetime prevalence of suicidal ideation among adolescents was lower in 2005 than 1995, whereas the prevalence of suicide attempts remained stable. MDE was the strongest predictor of suicidality in both samples. In addition, several demographic, substance use, and violence exposure variables were significantly associated with increased risk of suicidal ideation and attempts in both samples, with female gender, nonexperimental drug use, and direct violence exposure being consistent risk factors in both samples.
DIAGNOSTIC AND THERAPEUTIC ADVANCES IN HEPATOLOGY Terlipressin : An Asset for Hepatologists !

A 48-year-old male with alcoholic cirrhosis who was abstinent from alcohol for 6 months was admitted for management of esophageal variceal bleeding. He had ascites and paracentesis ruled out spontaneous bacterial peritonitis (SBP). On admission, his hemoglobin was 8.6 g/dL, white blood cell (WBC) count 9,200, and platelets 66,000/lL. The serum bilirubin was 3.2 mg/dL, direct 2.8 mg/dL, creatinine 2.9 mg/dL in spite of volume resuscitation, and international normalized ratio (INR) 1.8. The primary questions were: What would be the role of terlipressin in the control of variceal bleeding; what is the role of terlipressin in the treatment of hepatorenal syndrome? Are there any factors that may be used a priori to determine which patient will benefit from terlipressin therapy?
Autism Spectrum Disorders in Infancy and Toddlerhood: A Review of the Evidence on Early Signs, Early Identification Tools, and Early Diagnosis

To date, the biological basis of autism spectrum disorders (ASDs) remains unknown. Thus, identification and diagnosis are reliant on behavioral presentation and developmental history. There have been significant advances in our knowledge of the early signs of ASD through the use of retrospective videotape analysis, parental report, screening studies, and more recently, studies on high-risk infant siblings. Despite behavioral markers being identified within the first year of life, the current average age of diagnosis for ASD remains at approximately 3 years or older. Consequently, these children are not receiving intervention in their early years, which is increasingly recognized as an important time to begin intervention. There remains little research on the prospective identification of these children in a community-based sample before 18 months. It is recommended that future prospective studies monitor behavior repeatedly over time, thereby increasing the opportunity to identify early manifestations of ASD and facilitating the charting of subtle behavioral changes that occur in the development of infants and toddlers with ASD.
An FPGA-based implementation of the MINRES algorithm

Due to continuous improvements in the resources available on FPGAs, it is becoming increasingly possible to accelerate floating point algorithms. The solution of a system of linear equations forms the basis of many problems in engineering and science, but its calculation is highly time consuming. The minimum residual algorithm (MINRES) is one method to solve this problem, and is highly effective provided the matrix exhibits certain characteristics. This paper examines an IEEE 754 single precision floating point implementation of the MINRES algorithm on an FPGA. It demonstrates that through parallelisation and heavy pipelining of all floating point components it is possible to achieve a sustained performance of up to 53 GFLOPS on the Virtex5-330T. This compares favourably to other hardware implementations of floating point matrix inversion algorithms, and corresponds to an improvement of nearly an order of magnitude compared to a software implementation.
An Evaluation of GuttaFlow2 in Filling Artificial Internal Resorption Cavities: An in vitro Study.

INTRODUCTION Obturation of root canal with internal resorption represents a major challenge in Endodontics. In spite of that, usual obturation techniques are often employed without considering the best technique to solve this problem. The goal of this study was to investigate the ability of GuttaFlow2 in filling artificial internal resorption cavities. MATERIALS AND METHODS The study sample included 36 human upper central incisors that were prepared using Protaper system (F4). Internal resorption cavities were prepared by cutting each tooth at 7 mm from the apex and preparing hemispherical cavities on both the sides and then re-attaching them. The sample was randomly separated into three groups (n = 12 in each group). In the first group, thermal injection technique (Obtura II) was employed and served as the control group. In the second group, injection of cold free-flow obturation technique with a master cone (GF2-C) was employed, whereas in the third group injection of cold free-flow obturation without a master cone (GF2) was followed. The teeth were re-cut at the same level as before and examined under a stereomicroscope. Subsequently, the captured images were transferred to AutoCAD program to measure the percentage of total filling "TF," gutta-percha "G," sealer "S," and voids "V" out of the total surface of the cross sections. RESULTS All materials showed high filling properties in terms of "total filling," ranging from 99.17% (for Obtura II) to 99.72% (for GF2-C). Regarding gutta-percha percentages of filling, they ranged from 83.15 to 83.93%, whereas those for the sealer ranged from 5.71 to 15.24%. GuttaFlow2 group with a master cone appeared to give the best results despite the insignificant differences among the three groups. CONCLUSION The GuttaFlow2 with a master cone technique seemed to be a promising filling material and gave results similar to those observed with Obtura II. It is recommended for use to obturate internal resorption cavities in clinical practice due to its good adaptability to root canal walls, ease of handling, and application. CLINICAL SIGNIFICANCE Internal resorption defects can be successfully filled with GuttaFlow2 material when supplemented with a master cone, and the results are comparable with those obtained with the Obtura II technique.
A ‘resource allocator’ for transcription based on a highly fragmented T7 RNA polymerase

Synthetic genetic systems share resources with the host, including machinery for transcription and translation. Phage RNA polymerases (RNAPs) decouple transcription from the host and generate high expression. However, they can exhibit toxicity and lack accessory proteins (σ factors and activators) that enable switching between different promoters and modulation of activity. Here, we show that T7 RNAP (883 amino acids) can be divided into four fragments that have to be co‐expressed to function. The DNA‐binding loop is encoded in a C‐terminal 285‐aa ‘σ fragment’, and fragments with different specificity can direct the remaining 601‐aa ‘core fragment’ to different promoters. Using these parts, we have built a resource allocator that sets the core fragment concentration, which is then shared by multiple σ fragments. Adjusting the concentration of the core fragment sets the maximum transcriptional capacity available to a synthetic system. Further, positive and negative regulation is implemented using a 67‐aa N‐terminal ‘α fragment’ and a null (inactivated) σ fragment, respectively. The α fragment can be fused to recombinant proteins to make promoters responsive to their levels. These parts provide a toolbox to allocate transcriptional resources via different schemes, which we demonstrate by building a system which adjusts promoter activity to compensate for the difference in copy number of two plasmids.
Use of Radiocontrast Agents in CKD and ESRD

Contrast exposure in a population with chronic kidney disease (CKD) requires additional consideration given the risk of contrast‐induced nephropathy (CIN) after exposure to iodinated contrast as well as systemic injury with exposure to gadolinium‐based contrast agents (GBCA). Strategies to avoid CIN, and manage patients after exposure, including extracorporeal removal of contrast media, may differ among an advanced CKD population as compared to a general population. There is strong evidence to support the use of isotonic volume expansion and the lowest dose of low‐osmolar or iso‐osmolar contrast media possible to decrease CIN. The current literature on other newer prophylactic strategies such as statins, remote ischemic preconditioning, discontinuation of renin angiotensin aldosterone system (RAAS) blockade, and RenalGuard is limited thus these strategies cannot currently be recommended as routine prophylaxis for CIN. The use of extracorporeal removal of contrast agents as prophylaxis to reduce CIN has been the subject of multiple studies; however, data do not support a beneficial effect in reduction in CIN. Immediate removal of contrast by dialysis in a maintenance dialysis population is also not recommended, unless an individual's cardiopulmonary status is dependent on strict volume management. In patients with reduced renal function, GCBA exposure increases the risk of NSF. In patients with AKI, CKD stage 3 or greater (eGFR <30 ml/minute/1.73 m2), or patients on dialysis, we do not recommend the use of GBCA and alternative imaging modalities should be considered. If patients absolutely need magnetic resonance imaging with GBCA, we recommend the use of the lowest dose possible of the newer macrocylic, ionic agents (gadoterate meglumine) as well as immediate postprocedural HD in patients already on HD or peritoneal dialysis or with stage 5 CKD and with a functioning dialysis access already in place.
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The effects of monoclonal antibodies (mAbs) to cell-surface molecules, divalent cations, and various cell-signaling and metabolic inhibitors on the binding of thymocytes to rat thymic dendritic cells (TDC) were studied using a rosette assay. It was found that TDC/ thymocyte adhesion was stronger and faster at 37C than at 4C. Flow cytometric analysis demonstrated that bound thymocytes were predominantly CD4/CD8 and CD4+CD8-, but in comparison to the phenotype of whole thymocytes, they were enriched in the mature
The role of progesterone in prevention of preterm birth

Preterm birth continues to provide an enormous challenge in the delivery of perinatal health care, and is associated with considerable short and long-term health consequences for surviving infants. Progesterone has a role in maintaining pregnancy, by suppression of the calcium–calmodulin–myosin light chain kinase system. Additionally, progesterone has recognized anti-inflammatory properties, raising a possible link between inflammatory processes, alterations in progesterone receptor expression and the onset of preterm labor. Systematic reviews of randomized controlled trials evaluating the use of intramuscular and vaginal progesterone in women considered to be at increased risk of preterm birth have been published, with primary outcomes of perinatal death, preterm birth <34 weeks, and neurodevelopmental handicap in childhood. Eleven randomized controlled trials were included in the systematic review, involving 2714 women and 3452 infants, with results presented according to the reason women were considered to be at increased risk of preterm birth. While there is a potential beneficial effect in the use of progesterone for some women considered to be at increased risk of preterm birth, primarily in the reduction in the risk of preterm birth before 34 weeks gestation, it remains unclear if the observed prolongation of pregnancy translates into improved health outcomes for the infant.
Effect of Supra-Lactate Threshold Training on the Relationship between Mechanical Stride Descriptors and Aerobic Energy Cost in Trained Runners

The aim of this study was to determine the effect of endurance training on the relationship between mechanical stride descriptors (stride rate and stride rate variability) and the aerobic energy cost that would be decreased by training in an all-out supra-lactate threshold run. Six long distance runners (175 ± 6 cm; 72 ± 9 kg; 27 ± 4 years) performed two identical track tests before and after 8 weeks of supra-lactate threshold training: an incremental test and a constant load test at 50% of the velocity difference between the lactate threshold and V̇O 2max (vω50). During the constant load test, aerobic energy cost (EC), stride rate (SR) and stride rate variability (SRV) were measured. The constant load tests were carried out before and after training at the same absolute intensity, in order to compare stride mechanical descriptors. Our results show that after eight weeks of intermittent running at vω50, the velocity associated with V̇O 2max (v V̇O 2max) increases (p = 0.03) due to the decrease of running economy (RE, p = 0.02), and not due to an increase in V̇O 2max (p = 0.5). EC remained unchanged with training (p > 0.1), but SRV was significantly reduced (p < 0.03). No relationship was observed before and after training between the stride rate variability and the aerobic energetic cost (rs < 0.5; p > 0.05). This study indicates that because of the initial level of the runners, endurance training has not induced an increased V̇O 2max, but a decrease of the SRV. Further studies have to be conducted with more subjects in order to elucidate the mechanisms underlying this decrease in SRV which is observed with training.
FITNESS TEST PROFILES AND TRAINING INTENSITIES IN SKILLED RACE-WALKERS

A broad profile of national standard race-walkers was obtained. Subjects were taller and had more body fat than competitive runners of comparable distance as found in the literature. Pulmonary function, blood pressure and maximal heart rates were similar to normal sedentary values. The group's somatotype was 2.5: 3: 4, low mesomorphy being reflected in inferior strength measures. Haematological status corresponded to the runners of Brotherhood et al (1975). Predicted V02 max (x = 70 ml kg min'1) was not related to performance. Time to exhaustion on a treadmill test correlated with 20 km race time (R = -.94; p <.001). Multiple regression equations derived to predict race performance from combinations of 4 to 6 personality traits were non-significant. Mean heart rate in typical training regimes was 167 beats min-for interval training at 13 kmrW1 on the track and 134 beats min' over a 2.1 h road walk at 10.3 kmh`1. Physiological strain was greater in uphill than in level or downhill walking (P <.001).
Compact, Portable, Modular, High-performance, Distributed Tactile Transducer Device Based on Lateral Skin Deformation

We describe a tactile transducer system that has a compact, yet modular design. The tactile transducer comprises a 6 × 10 piezo bimorph actuator array with a spatial resolution of 1.8 × 1.2 millimeter and a wide temporal bandwidth. The blocked force of the individual actuators can be changed (0.15 N, 0.22 N) by adjusting the cantilever mechanics to optimally match skins and/or applications. This tactile transducer is modular, appeals to ordinary fabrication methods, and can be assembled and dismantled in a short time for debugging and maintenance. It weighs 60 g, it is self-contained in a 150 cm3volume and may be interfaced to most computer, provided that two analog outputs and six digital IO lines are available. A pilot test was carried out where subjects were asked to detect a virtual line randomly located on an otherwise smooth virtual surface.
A comparison of fetal and neonatal heart rate variability at similar post-menstrual ages

Substantial differences of heart rate variability (HRV) were found between fetuses and prematurely born neonates in the high-frequency band of the power spectrum. The range of post-menstrual ages of the fetuses and neonates were closely matched in this study. Growth of HRV was observed in low-frequency and high-frequency bands, reflecting maturation of the autonomic nervous system. The higher level of fetal HRV in the high-frequency band persisted even after accounting for age-related changes. Multiscale entropy was also higher in fetuses than in prematurely born neonates. These results suggest that the autonomic balance is poorer among neonates born prematurely than in fetuses of identical post-menstrual age.
The Effects of Nutrients on the Biodegradation of Crude Oil

The results of this study deal with addition of nutrient to the contaminated media with the hydrocarbon compounds (crude oil) on degradation of this compounds by bacteria, Showed 14 isolates of bacteria exhibited good indications of ability to degrade crude oil, eight of which belongs to the genus Bacillus, two to Pseudomonas and four to Chromobacterium. Five of these promising strains were selected for further study, two of which (V10 and D35) belongs to the genus Bacillus and three (V16, D39 and W1) to Chromobacterium. The two Bacillus strains were further identified depending on biochemical tests as B. larvae (V10) and B. alcalophilus (D35). Strains D35, V10 and W1 were used as consortium for treatment. The addition of nitrogen, phosphorus or both fertilizers to the medium inoculated by a consortium of the bacterial strains D35,V10 and W1 resulted in improved crude oil degradation as revealed by chromatographic separation of the crude oil fractions.
Risk of recurrent spontaneous preterm birth: a systematic review and meta-analysis

Objective To determine the risk of recurrent spontaneous preterm birth (sPTB) following sPTB in singleton pregnancies. Design Systematic review and meta-analysis using random effects models. Data sources An electronic literature search was conducted in OVID Medline (1948–2017), Embase (1980–2017) and ClinicalTrials.gov (completed studies effective 2017), supplemented by hand-searching bibliographies of included studies, to find all studies with original data concerning recurrent sPTB. Study eligibility criteria Studies had to include women with at least one spontaneous preterm singleton live birth (<37 weeks) and at least one subsequent pregnancy resulting in a singleton live birth. The Newcastle-Ottawa Scale was used to assess study quality. Results Overall, 32 articles involving 55 197 women, met all inclusion criteria. Generally studies were well conducted and had a low risk of bias. The absolute risk of recurrent sPTB at <37 weeks’ gestation was 30% (95% CI 27% to 34%). The risk of recurrence due to preterm premature rupture of membranes (PPROM) at <37 weeks gestation was 7% (95% CI 6% to 9%), while the risk of recurrence due to preterm labour (PTL) at <37 weeks gestation was 23% (95% CI 13% to 33%). Conclusions The risk of recurrent sPTB is high and is influenced by the underlying clinical pathway leading to the birth. This information is important for clinicians when discussing the recurrence risk of sPTB with their patients.
Evaluating Magnetic Stimulation as an Innovative Approach for Treating Dry Eye Syndrome: Safety and Efficacy Initial study

Objective The objective of this study was to assess the safety and preliminary efficacy of repetitive magnetic stimulation (RMS) as an intervention for dry eye syndrome, focusing on symptom reduction. Methodology This investigation involved 22 adult participants diagnosed with moderate to severe dry eye syndrome. These individuals were subjected to RMS treatment targeting one or both eyes using the VIVEYE - Ocular Magnetic Neurostimulation System Ver 1.0 (Epitech-Mag LTD; NIH clinical trials registry #NCT03012698). A placebo-controlled group was also included for comparative analysis, with all subjects being monitored over a three-month period. The evaluation of safety encompassed monitoring changes in best corrected visual acuity, ocular pathology, and reporting of adverse events. Participant tolerance was gauged through questionnaires, measurements of intraocular pressure (IOP), Schirmers test, and vital signs. The efficacy of the treatment was assessed by comparing pre- and post-treatment scores on fluorescein staining (according to the National Eye Institute (NEI) grading) and patient-reported outcomes. Results The study found no significant changes in visual acuity, IOP, or Schirmer's test results between the RMS-treated and control groups (p<0.05), indicating RMS does not adversely affect these ocular functions. However, RMS treatment was associated with improved tear film stability (p=0.198 vs. p=0.045) and corneal health (p=0.52 vs. p=0.004), with no improvements in the control group. Initial symptom improvement was observed in both RMS-treated and placebo groups (p=0.007 vs p=0.008), suggesting RMS's potential for treating ocular surface conditions. Conclusion The findings of this study introduce repetitive magnetic stimulation (RMS) as a promising therapeutic option for dry eye syndrome, demonstrating its capability to promote corneal epithelium repair, enhance tear film stability, and improve subjective symptom evaluations without adversely affecting intraocular pressure, visual acuity, or tear production. This confirms the safety and suggests the efficacy of RMS therapy for dry eye conditions.
Type of activity pacing instruction affects physical activity variability in adults with symptomatic knee or hip osteoarthritis.

BACKGROUND In a previous pilot study, the effect of 2 types of activity pacing instruction, general versus tailored, on osteoarthritis symptoms was examined and fatigue improved in the tailored group. Because activity pacing involves instruction on physical activity engagement, we undertook this secondary analysis to examine how pacing instruction affected physical activity patterns. METHODS Thirty-two adults with knee or hip osteoarthritis, stratified by age and gender, received either tailored or general activity pacing instruction. All participants wore an accelerometer for 5 days that measured physical activity and allowed for repeated symptom assessment at baseline and 10-week follow-up. Activity patterns were assessed by examining physical activity variability (standard deviation of 5-day average activity counts per minute), and average activity level (5-day average activity counts per minute). RESULTS Physical activity variability decreased in the tailored group and increased in the general group. No significant group changes in average activity from baseline to 10-week follow-up were found. CONCLUSION In this pilot study, type of activity pacing instruction affected objective physical activity patterns in adults with OA. Tailored activity pacing was more effective at reducing high and low activity bouts corresponding to the message of keeping a steady pace to reduce symptoms.
Fat content and EPA and DHA levels of selected marine, freshwater fish and shellfish species from the east coast of Peninsular Malaysia

The total lipid contents and the concentration of eicosapentaenoic (EPA) and docosahexaenoic (DHA) fatty acid of fourteen selected marine, three freshwater fish species, four shellfish species and two selected canned fish species of East Coast of Peninsular Malaysia were determined. The fat content of all samples ranged from 1.01 % to 15.83 % with silver catfish reported to have the highest value. Most of the fish had fat amounts lower than 10% of their total weight. In general, DHA concentrations (50.50-165.21 µg/g) were significantly higher than EPA (11.12-55.38 µg/g) in all of the fish species analyzed. Among all marine fish species, the sixbar grouper recorded the highest concentration of DHA (165.21 µg/g) while barramundi had the highest concentration of EPA (55.38 µg/g). In conclusion, all fish and shellfish species are considered a good source of EPA and DHA, representing a very valuable essential nutrient for maintenance of human health.