Miracle-dz/UniFAR-FTUs huggingface dataset:
Combating the mental health stigma with nostalgia

We report research implicating nostalgia as an intrapersonal means of warding off the stigmatization of persons with mental illness. We hypothesized and found that nostalgia about an encounter with a person with mental illness improves attitudes toward the mentally ill. In Experiment 1, undergraduates who recalled an encounter with a mentally ill person while focusing on central (vs. peripheral) features of the nostalgia prototype reported a more positive outgroup attitude. This beneficial effect of nostalgia was mediated by greater inclusion of the outgroup in the self (IOGS). In Experiment 2, undergraduates who recalled a nostalgic (vs. ordinary) interaction with a mentally ill person subsequently showed a more positive outgroup attitude. Results supported a serial mediation model whereby nostalgia increased social connectedness, which predicted greater IOGS and outgroup trust. IOGS and outgroup trust, in turn, predicted more positive outgroup attitudes. We ruled out alternative explanations for the results (i.e., mood, perceived positivity, and typicality of the recalled outgroup member). The findings speak to the intricate psychological processes underlying the prejudice-reduction function of nostalgia and their interventional potential.
The Relationship Between Measures of Declarative Memory and the Test of Memory Malingering in Patients With and Without Temporal Lobe Dysfunction

ABSTRACT The relationship between performance on measures of declarative memory and a commonly used forced-choice recognition measure of malingering was explored. The Test of Memory Malingering (TOMM) was developed to be sensitive to lack of effort and/or simulated malingering while being relatively insensitive to neurological impairment. The present study was designed to examine the sensitivity of TOMM performance to memory related deficits in a group of individuals with memory impairment secondary to temporal lobe epilepsy (TLE). A group of individuals who displayed psychogenic non-epileptic seizures (PNES) in the absence of neurologic dysfunction were included as controls. For both groups, a combination of memory and emotion variables shared a significant proportion of variance with TOMM Trial 2 performance. A similar relationship held true for the PNES group when accounting for TOMM Retention Trial performance. In contrast, for epilepsy patients, memory but not emotional measures were significantly re.
Auditory processing of interaural timing information: New insights

Differences in the time‐of‐arrival of sounds at the two ears, or interaural temporal disparities (ITDs), constitute one of the major binaural cues that underlie our ability to localize sounds in space. In addition, ITDs contribute to our ability to detect and to discriminate sounds, such as speech, in noisy environments. For low‐frequency signals, ITDs are conveyed primarily by “cycle‐by‐cycle” disparities present in the fine‐structure of the waveform. For high‐frequency signals, ITDs are conveyed by disparities within the time‐varying amplitude, or envelope, of the waveform. The results of laboratory studies conducted over the past few decades indicate that ITDs within the envelopes of high‐frequency are less potent than those within the fine‐structure of low‐frequency stimuli. This is true for both measures of sensitivity to changes in ITD and for measures of the extent of the perceived lateral displacement of sounds containing ITDs. Colburn and Esquissaud ( 1976 ) hypothesized that it is differences in the specific aspects of the waveform that are coded neurally within each monaural (single ear) channel that account for the greater potency of ITDs at low frequencies rather than any differences in the more central binaural mechanisms that serve these different frequency regions. In this review, the results of new studies are reported that employed special high‐frequency “transposed” stimuli that were designed to provide the high‐frequency channels of the binaural processor with envelope‐based information that mimics waveform‐based information normally available only in low‐frequency channels. The results demonstrate that these high‐frequency transposed stimuli (1) yield sensitivity to ITDs that approaches, or is equivalent to, that obtained with “conventional” low‐frequency stimuli and (2) yield large extents of laterality that are similar to those measured with conventional low‐frequency stimuli. These findings suggest that by providing the high‐frequency channels of the binaural processor with information that mimics that normally available only at low frequencies, the potency of ITDs in the two frequency regions can be made to be similar, if not identical. These outcomes provide strong support for Colburn and Esquissaud's ( 1976 ) hypothesis. The use of high‐frequency transposed stimuli, in both behavioral and physiological investigations offers the promise of new and important insights into the nature of binaural processing. J Neurosci. Res. 66:1035–1046, 2001. © 2001 Wiley‐Liss, Inc.
Perceptions of Work and Nonwork

A sample of 178 individuals was asked to describe their work experiences, nonwork experiences, and their self-concept using the same set of 25 semantic differential scales. The same individuals also provided information regarding some limited aspects of their nonwork behavior. Comparisons of the semantic differential descriptions permitted each individual to be classified into one of the following four types: Spillover- Work-oriented, Spillover-Nonwork-oriented, Compensatory-Work-oriented, and Compensatory-Nonwork-oriented. Analysis of the content of the descriptions revealed that spillover individuals of both types described their work and nonwork experiences in positive terms. Compensatory individuals, however, showed sharp contrasts. Those who were work-oriented appeared to compensate for the level of variety, creativity, and challenge of their work by choosing nonwork activities with less of these characteristics. Compensatory-Nonwork-oriented individuals, however, compensated in the opposite direction and appeared to be actively making up for deprivations at work in their choice of nonwork activities.
Lipid profile in schoolchildren in Vitória - Brazil

Introduction: The growing prevalence of obesity is currently considered the most important nutritional disorder. It is characterized, according to the World Health Organization (WHO) as a worldwide epidemic in developing and developed countries. In an associated form, there is an increasing prevalence of dyslipidaemia. Aiming to improve the current situation and prevent the progression of the epidemic, the American Academy of Pediatrics recently reinforced the need for cholesterol screening in overweight children older than two years. Objective: To determine overweight and lipid profi le in children aged between six and nine years. Methods: A descriptive, cross-sectional study with children from Vitoria, ES. For nutritional classifi cation the Z-score > + 1 SD body mass index-for-age (according to WHO / 2007) was used; for the lipid profi le the Atherosclerosis Prevention Guidelines in Childhood were used. Anthropometric measurements (weight, height, waist circumference and triceps skinfold thickness) followed the standard techniques described by WHO. Data were organized and analysed using SPSS, version 8.5 and calculated the absolute, relative and mean (SD) frequencies and the association between overweight, lipid profile and other variables is adopted as signifi cant when p < 0.05. Results: The sample comprised a total of 511 children of both sexes (46.7% male), with a mean age of 101.6 ± 11.1 months. Overweight was found in 197 (38.5%) children: overweight in 71 (13.9%) and obesity in 126 (24.6%). Total cholesterol was elevated in 167 (32.7%) as were high LDL-C (136–27%). High triglycerides were found in 21 participants (4.1%). Signifi cant association was found between waist circumference and high levels of triglycerides (p = 0.019) and HDL-C (p = 0.033). Conclusion: Excess weight of the sample investigated is considered high and its health effects are important, with an increased total cholesterol greater than 32%. The high levels of HDL-C are protectivefactors for coronary heart disease, although the lipid profi le had been changed.
The anti-political economy

This paper develops Michel Callon's analysis of the technological economy in two ways. First, the paper is concerned with the way that political activity is framed through the use of a variety of technical devices. Arguing against the view that politics can be located in all forms of social and economic activity, the paper suggests that politics should be regarded as a rather specialist activity that is often directed towards 'anti-political' ends. Second, through a discussion of what the paper terms 'the fragility of metrological regimes' and the 'inventiveness of measurement', the paper argues that measurement and calculation can have the effect of disrupting the frame of politics, and creating a conduit for the cross-contamination of the economic and the political.
Recurrent Spontaneous Spreading Depolarizations Facilitate Acute Dendritic Injury in the Ischemic Penumbra

Spontaneous spreading depolarizations (SDs) occur in the penumbra surrounding ischemic core. These SDs, often referred to as peri-infarct depolarizations, cause vasoconstriction and recruitment of the penumbra into the ischemic core in the critical first hours after focal ischemic stroke; however, the real-time spatiotemporal dynamics of SD-induced injury to synaptic circuitry in the penumbra remain unknown. A modified cortical photothrombosis model was used to produce a square-shaped lesion surrounding a penumbra-like “area at risk” in middle cerebral artery territory of mouse somatosensory cortex. Lesioning resulted in recurrent spontaneous SDs. In vivo two-photon microscopy of green fluorescent protein-expressing neurons in this penumbra-like area at risk revealed that SDs were temporally correlated with rapid (<6 s) dendritic beading. Dendrites quickly (<3 min) recovered between SDs to near-control morphology until the occurrence of SD-induced terminal dendritic injury, signifying acute synaptic damage. SDs are characterized by a breakdown of ion homeostasis that can be recovered by ion pumps if the energy supply is adequate. Indeed, the likelihood of rapid dendritic recovery between SDs was correlated with the presence of nearby flowing blood vessels, but the presence of such vessels was not always sufficient for rapid dendritic recovery, suggesting that energy needs for recovery exceeded energy supply of compromised blood flow. We propose that metabolic stress resulting from recurring SDs facilitates acute injury at the level of dendrites and dendritic spines in metabolically compromised tissue, expediting penumbral recruitment into the ischemic core.
Expanded Metabolic Reconstruction of Helicobacter pylori (iIT341 GSM/GPR): an In Silico Genome-Scale Characterization of Single- and Double-Deletion Mutants

ABSTRACT Helicobacter pylori is a human gastric pathogen infecting almost half of the world population. Herein, we present an updated version of the metabolic reconstruction of H. pylori strain 26695 based on the revised genome annotation and new experimental data. This reconstruction, iIT341 GSM/GPR, represents a detailed review of the current literature about H. pylori as it integrates biochemical and genomic data in a comprehensive framework. In total, it accounts for 341 metabolic genes, 476 intracellular reactions, 78 exchange reactions, and 485 metabolites. Novel features of iIT341 GSM/GPR include (i) gene-protein-reaction associations, (ii) elementally and charge-balanced reactions, (iii) more accurate descriptions of isoprenoid and lipopolysaccharide metabolism, and (iv) quantitative assessments of the supporting data for each reaction. This metabolic reconstruction was used to carry out in silico deletion studies to identify essential and conditionally essential genes in H. pylori. A total of 128 essential and 75 conditionally essential metabolic genes were identified. Predicted growth phenotypes of single knockouts were validated using published experimental data. In addition, in silico double-deletion studies identified a total of 47 synthetic lethal mutants involving 67 different metabolic genes in rich medium.
Attenuating trabecular morphology associated with low magnesium diet evaluated using micro computed tomography

Objective The literature shows that bone mineral density (BMD) and the geometric architecture of trabecular bone in the femur may be affected by inadequate dietary intake of Mg. In this study, we used microcomputed tomography (micro-CT) to characterize and quantify the impact of a low-Mg diet on femoral trabecular bones in mice. Materials and methods Four-week-old C57BL/6J male mice were randomly assigned to 2 groups and supplied either a normal or low-Mg diet for 8weeks. Samples of plasma and urine were collected for biochemical analysis, and femur tissues were removed for micro-CT imaging. In addition to considering standard parameters, we regarded trabecular bone as a cylindrical rod and used computational algorithms for a technical assessment of the morphological characteristics of the bones. BMD (mg-HA/cm3) was obtained using a standard phantom. Results We observed a decline in the total tissue volume, bone volume, percent bone volume, fractal dimension, number of trabecular segments, number of connecting nodes, bone mineral content (mg-HA), and BMD, as well as an increase in the structural model index and surface-area-to-volume ratio in low-Mg mice. Subsequently, we examined the distributions of the trabecular segment length and radius, and a series of specific local maximums were identified. The biochemical analysis revealed a 43% (96%) decrease in Mg and a 40% (71%) decrease in Ca in plasma (urine excretion). Conclusions This technical assessment performed using micro-CT revealed a lower population of femoral trabecular bones and a decrease in BMD at the distal metaphysis in the low-Mg mice. Examining the distributions of the length and radius of trabecular segments showed that the average length and radius of the trabecular segments in low-Mg mice are similar to those in normal mice.
Are Age-Related Changes in Sleep Magnified in Individuals with Depressive Symptoms?

iii ABSTRACT Across the lifespan, sleep becomes shorter, lighter, and more prone to disturbances Additionally, the majority of depressed individuals experience sleep problems (e.g., Tsuno, Besset, & Ritchie, 2000). The present study examined main and interactive effects of age and depressive symptoms on sleep outcomes in a sample of 119 individuals (53 younger; 66 older) with and without depressive symptoms. Understanding how age affects sleep quality in individuals with depressive symptoms has implications for optimal treatment and prevention strategies at different stages in life. Results showed that greater depressive symptoms were significantly associated with poorer overall sleep quality (p < .01) and two components of sleep quality, namely daytime dysfunction (p < .01) and sleep disturbance (p < .05). Age was a significant predictor of sleep duration (p < .05). No significant interaction effects were found between age and depressive symptoms on sleep outcomes. The lack of age-related effects was surprising and reasons why age-related effects were not found are discussed.
Dealing with large sample sizes: comparison of a new one spot dot blot method to western blot.

BACKGROUND Western blot is the gold standard method to determine individual protein expression levels. However, western blot is technically difficult to perform in large sample sizes because it is a time consuming and labor intensive process. Dot blot is often used instead when dealing with large sample sizes, but the main disadvantage of the existing dot blot techniques, is the absence of signal normalization to a housekeeping protein. METHODS In this study we established a one dot two development signals (ODTDS) dot blot method employing two different signal development systems. The first signal from the protein of interest was detected by horseradish peroxidase (HRP). The second signal, detecting the housekeeping protein, was obtained by using alkaline phosphatase (AP). RESULTS Inter-assay results variations within ODTDS dot blot and western blot and intra-assay variations between both methods were low (1.04-5.71%) as assessed by coefficient of variation. CONCLUSIONS ODTDS dot blot technique can be used instead of western blot when dealing with large sample sizes without a reduction in results accuracy.
The Role of Social Context in Shaping Student-Athlete Opinions

How do student-athletes form opinions? This is a particularly important question given ongoing debates about whether student-athletes should be paid and/or allowed to unionize. These debates concern the rights and benefits accrued directly to student-athletes, and thus, understanding their attitudes is of obvious import. Yet, virtually no recent work has delved into how student-athletes form opinions on these issues. We fill this gap with a theoretical framework that predicts changes in social context alter opinions. This leads to the hypothesis that opinions will change once a student-athlete completes his/her career and finds him/herself in a distinct social network. We test the prediction with a survey, implemented in 2012, of one of the most notable athletic conferences in the National Collegiate Athletic Association (NCAA): the Big Ten. We find that post-career student-athletes demonstrate higher levels of support for pay for play and unionization. Our results suggest that student-athletes' opinions seem to depend on their extant social contexts. While our data, from 2012, neither speak to current opinions – given the quickly evolving landscape of college athletics – nor demonstrate what reforms may be “best,” they do accentuate the power of social context in shaping student-athletes' attitudes.
Analysis of very low quality speech for mask-based enhancement

The complexity of the speech enhancement problem has motivated many different solutions. However, most techniques address situations in which the target speech is fully intelligible and the background noise energy is low in comparison with that of the speech. Thus while current enhancement algorithms can improve the perceived quality, the intelligibility of the speech is not increased significantly and may even be reduced. Recent research shows that intelligibility of very noisy speech can be improved by the use of a binary mask, in which a binary weight is applied to each time-frequency bin of the input spectrogram. There are several alternative goals for the binary mask estimator, based either on the Signalto-Noise Ratio (SNR) of each time-frequency bin or on the speech signal characteristics alone. Our approach to the binary mask estimation problem aims to preserve the important speech cues independently of the noise present by identifying time-frequency regions that contain significant speech energy. The speech power spectrum varies greatly for different types of speech sound. The energy of voiced speech sounds is concentrated in the harmonics of the fundamental frequency while that of unvoiced sounds is, in contrast, distributed across a broad range of frequencies. To identify the presence of speech energy in a noisy speech signal we have therefore developed two detection algorithms. The first is a robust algorithm that identifies voiced speech segments and estimates their fundamental frequency. The second detects the presence of sibilants and estimates their energy distribution. In addition, we have developed a robust algorithm to estimate the active level of the speech. The outputs of these algorithms are combined with other features estimated from the noisy speech to form the input to a classifier which estimates a mask that accurately reflects the time-frequency distribution of speech energy even at low SNR levels. We evaluate a mask-based speech enhancer on a range of speech and noise signals and demonstrate a consistent increase in an objective intelligibility measure with respect to noisy speech.
Active Vision: The Psychology of Looking and Seeing

PASSIVE VISION AND ACTIVE VISION 1.1 Introduction 1.2 Passive vision 1.3 Visual attention 1.4 Active vision 1.5 Active vision and vision for action 1.6 Outline of the book BACKGROUND TO ACTIVE VISION 2.1 Introduction 2.2 The inhomogeneity of the visual projections 2.3 Parallel visual pathways 2.4 The oculomotor system 2.5 Saccadic eye movements 2.6 Summary VISUAL SELECTION, COVERT ATTENTION AND EYE MOVEMENTS 3.1 Covert and overt attention 3.2 Covert spatial attention 3.3 The relationship between covert and overt attention 3.4 Speed of attention 3.5 Neurophysiology of attention 3.6 Non-spatial attention 3.7 Active vision and attention 3.8 Summary VISUAL ORIENTING 4.1 Introduction 4.2 What determines the latency of orienting saccades? 4.3 Physiology of saccade initiation 4.4 What determines the landing position of orienting saccades? 4.5 Physiology of the WHERE system 4.6 The Findlay and Walker model 4.7 Development and plasticity VISUAL SAMPLING DURING TEXT READING 5.1 Introduction 5.2 Basic patterns of visual sampling during reading 5.3 Perception during fixations in reading 5.4 Language processing 5.5 Control of fixation duration 5.6 Control of landing position 5.7 Theories of eye control during reading 5.8 Practical aspects of eye control in reading 5.9 Overview VISUAL SEARCH 6.1 Visual search tasks 6.2 Theories of visual search 6.3 The need for eye movements in visual search 6.4 Eye movements in visual search 6.5 Ocular capture in visual search 6.6 Saccades in visual search: scanpaths 6.7 Physiology of visual search 6.8 Summary NATURAL SCENES AND ACTIVITIES 7.1 Introduction 7.2 Analytic studies of scene and object perception 7.3 Dynamic scenes and situations 7.4 Summary HUMAN NEUROPSYCHOLOGY 8.1 Blindsight 8.2 Neglect 8.3 Balint's syndrome and dorsal simultanagnosia 8.4 Frontal lobe damage 8.5 Orienting without eye movements 8.6 Summary SPACE CONSTANCY AND TRANS-SACCADIC INTEGRATION 9.1 The traditional approach: 'compensatory taking into account' 9.2 Trans-saccadic integration 9.3 Resolution of the conflicting results 9.4 Conclusion: The Active Vision Cycle 9.5 Future directions
Age at onset of non-affective psychosis in relation to cannabis use, other drug use and gender

Background Cannabis use is associated with an earlier age at onset of psychotic illness. The aim of the present study was to examine whether this association is confounded by gender or other substance use in a large cohort of patients with a non-affective psychotic disorder. Method In 785 patients with a non-affective psychotic disorder, regression analysis was used to investigate the independent effects of gender, cannabis use and other drug use on age at onset of first psychosis. Results Age at onset was 1.8 years earlier in cannabis users compared to non-users, controlling for gender and other possible confounders. Use of other drugs did not have an additional effect on age at onset when cannabis use was taken into account. In 63.5% of cannabis-using patients, age at most intense cannabis use preceded the age at onset of first psychosis. In males, the mean age at onset was 1.3 years lower than in females, controlling for cannabis use and other confounders. Conclusions Cannabis use and gender are independently associated with an earlier onset of psychotic illness. Our findings also suggest that cannabis use may precipitate psychosis. More research is needed to clarify the neurobiological factors that make people vulnerable to this precipitating effect of cannabis.