Miracle-dz/UniFAR-FTUs huggingface dataset:
Eyelid Detection Method Based on a Fuzzy Multi-Objective Optimization

Iris recognition is one of the most robust human identification methods. In order to carry out accurate iris recognition, many factors of image quality should be born in mind. The eyelid occlusion is a quality factor that may significantly affect the accuracy. In this paper we introduce a new fuzzy multi-objective optimization approach based on the eyelid detection method. This method obtains the eyelid contour which represents the best solution of Pareto-optimal set taking into account five optimized objectives. This proposal is composed of three main stages, namely, gathering eyelid contour information, filtering eyelid contour and tracing eyelid contour. The results of the proposal are evaluated in a verification mode and thus a few performance measures are generated in order to compare them with other works of the state of the art. Thereby, the proposed method outperforms other approaches and it is very useful for implementing real applications as well.
OGLE-2003-BLG-262: Finite-Source Effects from a Point-Mass Lens

We analyze OGLE-2003-BLG-262, a relatively short (tE = 12.5 ± 0.1 day) microlensing event generated by a point-mass lens transiting the face of a K giant source in the Galactic bulge. We use the resulting finite-source effects to measure the angular Einstein radius, θE = 195 ± 17 μas, and so constrain the lens mass to the FWHM interval 0.08 < M/M☉ < 0.54. The lens-source relative proper motion is μrel = 27 ± 2 km s-1 kpc-1. Both values are typical of what is expected for lenses detected toward the bulge. Despite the short duration of the event, we detect marginal evidence for a "parallax asymmetry" but argue that this is more likely to be induced by acceleration of the source, a binary lens, or possibly by statistical fluctuations. Although OGLE-2003-BLG-262 is only the second published event to date in which the lens transits the source, such events will become more common with the new OGLE-III survey in place. We therefore give a detailed account of the analysis of this event to facilitate the study of future events of this type.
Genomic BCR‐ABL1 breakpoints in pediatric chronic myeloid leukemia

Chronic myeloid leukemia (CML) is a rare disease in children and adolescents and various aspects—from molecular genesis to therapy regimen—have been taken over from studies on the more prevalent adult CML. However, differences have been observed between malignancies with identical underlying chromosomal translocations, but occurring at different age groups, suggesting some diversity in the mechanisms of formation and leukemogenesis. A multiplex long‐range PCR‐based assay was developed to allow fast and reliable amplification of patient‐specific BCR‐ABL1 fusion sequences from genomic DNA. The localization of breakpoints was analyzed with respect to distribution within the breakpoint cluster regions, sequence features, and association to repetitive elements or motifs associated with DNA recombination. The genomic fusion sites of 59 pediatric CML patients showed a bimodal breakpoint distribution in BCR that was different from the distribution in adult CML cases, but with similarities to BCR‐ABL1‐positive, acute lymphoblastic leukemia in adults. BCR breakpoints were found more frequently positioned within, or close to, Alu repeats than would be expected based on their overall sequence proportion. Technical aspects of the highly sensitive DNA‐based quantification of residual CML cells by specific fusion sequence during tyrosine kinase inhibitor therapy are exemplified in a subcohort of pediatric CML patients. © 2012 Wiley Periodicals, Inc.
3D Fluorescence‐Based Security Features by 3D Laser Lithography

3D optical security features manufactured by multistep 3D optical laser lithography are presented. These microstructures are composed of a nonfluorescent 3D cross‐grid scaffold and fluorescent markers, realized by an acrylate‐based resist containing CdSSe‐based core–shell semiconductor quantum dots, arranged onto this scaffold at will. The readout of these 3D microstructures can be (exclusively) achieved by optical sectioning methods, for example, 3D confocal fluorescence laser scanning microscopy. As examples, structures with five different layers of markers and one emission color and two different colors, respectively, are shown. This class of deterministic 3D microstructures can be embedded into thin polymer films, can be individualized, and allows for plenty of future variations and extensions. It therefore represents an interesting avenue beyond established 2D holographic or 2D fluorescent optical security features.
Retrospective assessment of prevalence of nephrogenic systemic fibrosis (NSF) after implementation of a new guideline for the use of gadobenate dimeglumine as a sole contrast agent for magnetic resonance examination in renally impaired patients

From May 2007 to January 2008, patients with Stage 3‐5 chronic kidney disease (CKD) undergoing gadobenate dimeglumine (GBD)‐enhanced magnetic resonance (MR) examinations were included in the retrospective investigation. The electronic medical records were reviewed to assess the prevalence of nephrogenic systemic fibrosis (NSF) in renally impaired patients underwent GBD‐enhanced MR examinations. In all, 250 patients (98 men, mean age 72.6 years) were included: 97% of the patients had Stage 3 CKD (estimated GFR 30–59 mL/min/1.73 m2); 37% had been exclusively exposed to GBD. The remaining were exposed to GBD and other gadolinium‐based contrast agents (GBCAs). The mean dose of GBD was 22 mL (standard deviation [SD], 11.2). Including exposure to other GBCAs, the mean cumulative dose of gadolinium was 61 mL (SD, 62.3). A total of 206 patients (82%) had skin examinations following the last GBD administration (mean duration, 108 days). No evidence of suspected or diagnosed NSF was found. In conclusion, on the basis of a retrospective chart review there was no skin evidence of NSF in predominantly Stage 3 CKD patients who were exposed to GBD at an average follow‐up of 108 days, either solely or in combination with other GBCAs. J. Magn. Reson. Imaging 2009;30:1335–1340. © 2009 Wiley‐Liss, Inc.
A SVM Method for Continuous Blood Pressure Estimation from a PPG Signal

There is not always a linear relationship between the blood pressure and the pulse duration obtained from photoplethysmography (PPG) signal. In order to estimate the blood pressure from the PPG signal, A Support Vector Machine (SVM) method for continuous blood pressure estimation from a PPG Signal is applied in this paper. Training data were extracted from The University of Queensland Vital Signs Dataset for better representation of possible pulse and pressure variation. In total there were more than 7000 heartbeats and 9 parameters to be extracted from each other for analysis, then these features were defined as the input vector for training. The comparison between estimated and reference values shows better accuracy than the linear regression method and also shows better accuracy than the ANN method in diastolic blood pressure, which brings great significance in the field of mobile wearable.
Human 3D vascularized organotypic microfluidic assays to study breast cancer cell extravasation

Significance The cancer biology seed-and-soil paradigm recognizes the existence of organ-specific patterns of metastasization that drive the spread of selected primary tumors toward specific secondary loci. However, despite efforts to model the organotypic microenvironment, the organ specificity of cancer metastases needs to be elucidated. The relevance of this study lies in the generation of a human vascularized organ-specific microenvironment, which can be used to investigate and tune the extravasation process of metastatic tumor cells. Furthermore, beyond mimicking the pro- or antimetastatic signatures of different microenvironments, our microfluidic model provides insights into different properties of organ-specific endothelia. This study paves the way toward advanced in vitro models to screen for highly tailored organ-specific therapeutics and investigate key molecular pathways involved in organ-specific metastases. A key aspect of cancer metastases is the tendency for specific cancer cells to home to defined subsets of secondary organs. Despite these known tendencies, the underlying mechanisms remain poorly understood. Here we develop a microfluidic 3D in vitro model to analyze organ-specific human breast cancer cell extravasation into bone- and muscle-mimicking microenvironments through a microvascular network concentrically wrapped with mural cells. Extravasation rates and microvasculature permeabilities were significantly different in the bone-mimicking microenvironment compared with unconditioned or myoblast containing matrices. Blocking breast cancer cell A3 adenosine receptors resulted in higher extravasation rates of cancer cells into the myoblast-containing matrices compared with untreated cells, suggesting a role for adenosine in reducing extravasation. These results demonstrate the efficacy of our model as a drug screening platform and a promising tool to investigate specific molecular pathways involved in cancer biology, with potential applications to personalized medicine.
Virtual implant planning in the edentulous maxilla: criteria for decision making of prosthesis design.

OBJECTIVES To evaluate prosthetic parameters in the edentulous anterior maxilla for decision making between fixed and removable implant prosthesis using virtual planning software. MATERIAL AND METHODS CT- or DVT-scans of 43 patients (mean age 62 ± 8 years) with an edentulous maxilla were analyzed with the NobelGuide software. Implants (≥3.5 mm diameter, ≥10 mm length) were virtually placed in the optimal three-dimensional prosthetic position of all maxillary front teeth. Anatomical and prosthetic landmarks, including the cervical crown point (C-Point), the acrylic flange border (F-Point), and the implant-platform buccal-end (I-Point) were defined in each middle section to determine four measuring parameters: (1) acrylic flange height (FLHeight), (2) mucosal coverage (MucCov), (3) crown-Implant distance (CID) and (4) buccal prosthesis profile (ProsthProfile). Based on these parameters, all patients were assigned to one of three classes: (A) MucCov ≤ 0 mm and ProsthProfile≥45(0) allowing for fixed prosthesis, (B) MucCov = 0-5 mm and/or ProsthProfile = 30(0) -45(0) probably allowing for fixed prosthesis, and (C) MucCov ≥ 5 mm and/or ProsthProfile ≤ 30(0) where removable prosthesis is favorable. Statistical analyses included descriptive methods and non-parametric tests. RESULTS Mean values were for FLHeight 10.0 mm, MucCov 5.6 mm, CID 7.4 mm, and ProsthProfile 39.1(0) . Seventy percent of patients fulfilled class C criteria (removable), 21% class B (probably fixed), and 2% class A (fixed), while in 7% (three patients) bone volume was insufficient for implant planning. CONCLUSIONS The proposed classification and virtual planning procedure simplify the decision-making process regarding type of prosthesis and increase predictability of esthetic treatment outcomes. It was demonstrated that in the majority of cases, the space between the prosthetic crown and implant platform had to be filled with prosthetic materials.
bot.zen @ EmpiriST 2015 - A minimally-deep learning PoS-tagger (trained for German CMC and Web data)

This article describes the system that participated in the Part-of-speech tagging subtask of the EmpiriST 2015 shared task on automatic linguistic annotation of computer-mediated communication / social media . The system combines a small assertion of trending techniques, which implement matured methods, from NLP and ML to achieve competitive results on PoS tagging of German CMC and Web corpus data; in particular, the system uses word embeddings and character-level representations of word beginnings and endings in a LSTM RNN architecture. Labelled data (Tiger v2.2 and EmpiriST) and unlabelled data (German Wikipedia) were used for training. The system is available under the APLv2 open-source license.
Duration of prodromal phase and severity of volumetric abnormalities in first-episode psychosis.

BACKGROUND First-episode psychosis is typically preceded by a prodrome in which there is deterioration in global and social functioning. AIMS To examine whether the duration of the prodromal phase influences grey and white matter volumes at the onset of psychosis. METHODS Eighty-two people were scanned using magnetic resonance imaging when they developed a first episode of psychosis. The duration of the prodromal phase was estimated from detailed interviews and medical records. Voxel-based morphometry was used to assess neuroanatomical abnormalities. RESULTS A long prodromal phase was associated with smaller grey matter volumes in the cingulate, frontal and left insular cortex, and with less white matter volume bilaterally in the superior longitudinal and uncinate fasciculi and the cingulum. CONCLUSIONS The severity of volumetric abnormalities in first-episode psychosis was greater in those with a long prodrome.
Binding and assembly of actin filaments by plasma membranes from Dictyostelium discoideum

The binding of native, 125I-Bolton-Hunter-labeled actin to purified Dictyostelium discoideum plasma membranes was measured using a sedimentation assay. Binding was saturable only in the presence of the actin capping protein, gelsolin. In the presence of gelsolin, the amount of actin bound at saturation to three different membrane preparations was 80, 120, and 200 micrograms/mg of membrane protein. The respective concentrations of actin at half-saturation were 8, 12, and 18 micrograms/ml. The binding curves were sigmoidal, indicating positive cooperativity at low actin concentrations. This cooperativity appeared to be due to actin-actin associations during polymerization, since phalloidin converted the curve to a hyperbolic shape. In kinetic experiments, actin added as monomers bound to membranes at a rate of 0.6 microgram ml-1 min-1, while pre-polymerized actin bound at a rate of 3.0 micrograms ml-1 min-1. Even in the absence of phalloidin, actin bound to membranes at concentrations well below the normal critical concentration. This membrane-bound actin stained with rhodamine- phalloidin and was cross-linked by m-maleimidobenzoyl succinimide ester, a bifunctional cross-linker, into multimers with the same pattern observed for cross-linked F-actin. We conclude that D. discoideum plasma membranes bind actin specifically and saturably and that these membranes organize actin into filaments below the normal critical concentration for polymerization. This interaction probably occurs between multiple binding sites on the membrane and the side of the actin filament, and may be related to the clustering of membrane proteins.
Numerical Assessment Of Water Alternating Gas Practices In The Presence Of Hysteresis Effects On Relative Permeability

Summary Water Alternating Gas (WAG) injection is one of the most successful enhanced oil recovery approaches. Properly accounting for the hysteretic effects of relative permeabilities is a critical issue encountered in numerical simulations of WAG at the mesoscale. Ranaee et al. (2015) proposed a sigmoid-based model for three-phase oil relative permeability, incorporating key physical effects taking place at the pore scale. The model can then be jointly used with the Larsen and Skauge (1998) model, accounting for gas relative permeability hysteresis, to develop a formulation for three-phase relative permeability suitable for reservoir simulation. In this study we illustrate the impact of this joint formulation on a field scale setting through a suite of numerical simulations of WAG injection targeting a reservoir model inspired to real life cases. The analysis is performed by embedding the illustrated relative permeability models in the black oil model implemented in the Matlab Reservoir Simulation Toolbox (Lie et al., 2011). We assume non-hysteretic behavior for water relative permeability under water-wet conditions and characterize it upon relying on corresponding laboratory-scale data. As a baseline, the results are compared against a scenario in the absence of three-phase relative permeability hysteresis. The computational domain is heterogeneous, the spatial distributions of porosity and absolute permeability varying across the ranges of [0.02 - 0.3] and [0.1 - 2600 mD], respectively. The model is set at equilibrium conditions, production being driven by three peripheral injectors and five up-dip producers. A given flow rate is assigned to each injector and a target value of liquid production rate is imposed at the producing wells. The numerically evaluated production rates constitute our target state variables. The schedule of the injectors is set to achieve a preliminary waterflooding phase followed by a WAG injection scheme. The latter is implemented by periodically switching the injected phase between water and gas for two injectors, the third injector continuously injecting water. The numerical simulations are performed through a fully implicit discretization of the equations governing the system dynamics. To minimize computational costs, we employ an algebraic multi-grid method and resort to a multi-processor high performance clustered computer system. Our results suggest that hysteretic effects are important across significant portions of the studied reservoir system. Field production responses are associated with a simultaneous increase of ultimate oil recovery and a corresponding decline of the gas-oil ratio when hysteretic effects are included in the simulations.
Methoxychlor-induced ovarian follicle toxicity in mice: dose and exposure duration-dependent effects.

BACKGROUND Methoxychlor (MXC) is specifically known to target ovarian antral follicles, increasing atresia (death via apoptosis) in them. This is of concern because females are born with a finite pool of ovarian follicles. Only limited studies have explored the phenomenon of a reduced fertility threshold for effect based on the percentage of antral follicle atresia. METHODS In this article, we report on adult female CD-1 mice exposed intraperitoneally to various doses of MXC for 5, 10, 20, and 30 days. In the 20-day treatment, mice were dosed with either the vehicle or MXC at 64 or 96 mg/kg/day, whereas in the 30-day treatment, mice were dosed with vehicle or MXC at 48, 64, or 96 mg/kg/day. The mice that were dosed with MXC for 30 days were also mated with untreated males for a determination of overall fertility. RESULTS A significantly increased percentage (50%) of atretic antral follicles was observed only after 20 and 30 days of treatment. Specifically, mice treated with MXC64 for 20 and 30 days had an increased percentage of atretic antral follicles compared with vehicle-treated mice. Interestingly, mice dosed with MXC96 had an increased percentage of atretic antral follicles after 30 days, but not after 20 days of treatment compared with vehicle-treated mice. Overall fertility of the mice was not different compared with controls. CONCLUSIONS The results indicate that as much as a 50% increase in atretic antral follicles does not affect the immediate fertility of the mice.
MAVRIC Flutter Model Transonic Limit Cycle Oscillation Test

The Models for Aeroelastic Validation Research Involving Computation semi-span wind-tunnel model (MAVRIC-I), a business jet wing-fuselage flutter model, was tested in NASA Langley''s Transonic Dynamics Tunnel with the goal of obtaining experimental data suitable for Computational Aeroelasticity code validation at transonic separation onset conditions. This research model is notable for its inexpensive construction and instrumentation installation procedures. Unsteady pressures and wing responses were obtained for three wingtip configurations: clean, tipstore, and winglet. Traditional flutter boundaries were measured over the range of M = 0.6 to 0.9 and maps of Limit Cycle Oscillation (LCO) behavior were made in the range of M = 0.85 to 0.95. Effects of dynamic pressure and angle-of-attack were measured. Testing in both R134a heavy gas and air provided unique data on Reynolds number, transition effects, and the effect of speed of sound on LCO behavior. The data set provides excellent code validation test cases for the important class of flow conditions involving shock-induced transonic flow separation onset at low wing angles, including Limit Cycle Oscillation behavior.
Growth hormone should be used only for approved indications.

University of North Carolina School of Medicine (D.R.C.), Chapel Hill, North Carolina 27594; Northwestern University (M.M.), Chicago, Illinois 60611; VA Palo Alto Heath Care System (A.R.H.), Palo Alto, California 94304; Massachusetts General Hospital (A.K.), Boston, Massachusetts 02114; Charite Medical Faculty Berlin (C.J.S.), Germany D-10187; New York School of Medicine (D.L.K.), New York, New York 10016; Princess Alexandra Hospital (K.H.), Brisbane, Australia 4102; Autonomous University of Barcelona (S.M.W.), Barcelona, Spain; Hospital das Clinicas (M.D.B.), Sao Paula, Brazil; Gasthuisberg Campus; Katholieke Universitat (R.B.), Leuven, Belgium; Cedars Sinai Health Center (A.B.-S.), Los Angeles, California 96048; Cleveland Clinic Foundation (A.M.H.), Cleveland, Ohio 44195; Hopitaux Universitaires Paris-Sud (P.C.), Le Kremlin Bicetre F-94275, France; University of Michigan Medical Center (A.L.B.), Ann Arbor, Michigan 48109; University of Washington (G.R.M.), Seattle, Washington 98195; Veterans Administration Medical Center (M.R.B.), Washington, DC 20427; and Johns Hopkins School of Medicine (R.S.), Baltimore, Maryland 21287
Hydrodeoxygenation of Methyl Laurate over Ni Catalysts Supported on Hierarchical HZSM-5 Zeolite

The hierarchical HZSM-5 zeolite was prepared successfully by a simple NaOH treatment method. The concentration of NaOH solution was carefully tuned to optimal the zeolite acidity and pore structure. Under NaOH treatment conditions, a large number of mesopores, which interconnected with the retained micropores, were created to facilitate mass transfer performance. There are very good correlations between the decline of the relative zeolite crystallinity and the loss of micropores volume. The Ni nanoclusters were uniformly confined in the mesopores of hierarchical HZSM-5 by the excessive impregnation method. The direct deoxygenation in N2 and hydrodeoxygenation in H2 of the methyl laurate were compared respectively over the Ni/HZSM-5 catalysts. In the N2 atmosphere, the deoxygenation rate of the methyl laurate on the Ni/HZSM-5 catalyst is relatively slow. In the presence of H2, the synergistic effect between the hydrogenation function of the metal and the acid function of the zeolite supports can make the deoxygenation level more obvious. The yield of hydrocarbon products gradually reached the maximum with the appropriate treatment concentration of 1M NaOH, which could be attributed to the improved mass transfer in the hierarchical HZSM-5 supports.