Miracle-dz/UniFAR-FTUs huggingface dataset:
Two X-ray bright cataclysmic variables with unusual activities: GZ Cnc and NSV 10934

We report on a discovery of unexpected activities in two X-ray bright dwarf novae. GZ Cnc showed an anomalous clustering of outbursts in 2002, in contrast to a low outburst frequency in the past record. The activity resembles an increased activity seen in some intermediate polars or candidates. We identified NSV 10934, X-ray selected high-amplitude variable star, as a dwarf nova with unusually rapid decline. The outburst characteristics make NSV 10934 a twin of recently discovered intermediate polar (HT Cam) with dwarf nova-type outbursts. We propose that these activities in X-ray strong dwarf novae may be a previously overlooked manifestation of outburst activities in magnetic cataclysmic variables.
Determining EGFR-TKI sensitivity of G719X and other uncommon EGFR mutations in non-small cell lung cancer: Perplexity and solution

Mutations in epidermal growth factor receptor (EGFR) play critical roles in the pathogenesis of non-small cell lung cancer (NSCLC), and they are highly associated with sensitivity to tyrosine kinase inhibitors (TKIs). While the pathogenic and pharmacological characteristics of common mutations in EGFR have been thoroughly investigated, those of uncommon mutations remain to be elucidated. Traditional approaches to study common mutations by randomized controlled trials are not feasible for uncommon mutations owing to their rarity. Therefore, by systematically reviewing laboratory and clinical studies of the G719X mutation, one of the uncommon mutations, we concluded that the G719X mutation was intermediately sensitive to TKIs, with an average response rate of 35.1% (47/134). Moreover, accordingly, we proposed a comprehensive model to investigate uncommon mutations in EGFR. The model involves both basic and clinical components, composed of structural analyses, functional alterations, cell viabilities and animal models with various types of clinical studies. In this review, we systematically reviewed studies of the G719X mutation and put forward a research model that could be generalized to explore uncommon mutations in diseases associated with gene mutations.
A Physically Based Climatology of the Occurrence and Intensification of Australian East Coast Lows

The subtropical part of the eastern Australian seaboard experiences intense cyclonic activity. The severe damage caused by the intense storms in the region, known as east coast lows (ECLs), has motivated a number of recent studies. Cyclones in this region appear to be driven by a combination of different (barotropic and baroclinic) formation mechanisms, consistent with the view emerging in the last decades that cyclones span a continuous spectrum of dynamical structures, with the barotropically driven tropical cyclone and the baroclinically driven extratropical cyclone being only the extremes of such a spectrum. In this work we revisit the climatology of cyclone occurrence in the subtropical east coast of Australia as seen in a global reanalysis, systematically applying classification criteria based on the cyclone vertical structure and thermal core. Moreover, we investigate the underlying processes driving the cyclone rapid intensification by means of an atmospheric limited-area energetics analysis. We show that ECLs have different spatial patterns according to the cyclone thermal structure, with the fraction of hybrid cyclones being larger toward the tropics and closer to the coast. Moreover, we find that explosively deepening cyclones in this region are driven by a different combination of processes with respect to the global case, with barotropic processes in the surrounding environment having a more dominant role in the energetics of cyclone rapid intensification. The findings of this work contribute to understanding the physical processes underlying the formation and intensification of Australian east coast lows and the associated coastal damage and risk.
Optimal designs for space-time linear precoders and decoders

We introduce a new paradigm for the design of transmitter space-time coding that we refer to as linear precoding. It leads to simple closed-form solutions for transmission over frequency-selective multiple-input multiple-output (MIMO) channels, which are scalable with respect to the number of antennas, size of the coding block, and transmit average/peak power. The scheme operates as a block transmission system in which vectors of symbols are encoded and modulated through a linear mapping operating jointly in the space and time dimension. The specific designs target minimization of the symbol mean square error and the approximate maximization of the minimum distance between symbol hypotheses, under average and peak power constraints. The solutions are shown to convert the MIMO channel with memory into a set of parallel flat fading subchannels, regardless of the design criterion, while appropriate power/bits loading on the subchannels is the specific signature of the different designs. The proposed designs are compared in terms of various performance measures such as information rate, BER, and symbol mean square error.
Sports participation and health-related behaviors among US youth.

OBJECTIVE To examine the relationship between sports participation and health-related behaviors among high school students. DESIGN Cross-sectional design using data from the 1997 Centers for Disease Control and Prevention Youth Risk Behavior Survey. PARTICIPANTS A nationally representative sample of 14,221 US high school students. MAIN OUTCOME MEASURES Prevalence of sports participation among males and females from 3 ethnic groups and its associations with other health behaviors, including diet, tobacco use, alcohol and illegal drug use, sexual activity, violence, and weight loss practices. RESULTS Approximately 70% of male students and 53% of female students reported participating on 1 or more sports teams in school and/or nonschool settings; rates varied substantially by age, sex, and ethnicity. Male sports participants were more likely than male nonparticipants to report fruit and vegetable consumption on the previous day and less likely to report cigarette smoking, cocaine and other illegal drug use, and trying to lose weight. Compared with female nonparticipants, female sports participants were more likely to report consumption of vegetables on the previous day and less likely to report having sexual intercourse in the past 3 months. Among white males and females, several other beneficial health behaviors were associated with sports participation. A few associations with negative health behaviors were observed in African American and Hispanic subgroups. CONCLUSION Sports participation is highly prevalent among US high school students, and is associated with numerous positive health behaviors and few negative health behaviors.
ACT-MAC: An asynchronous cooperative transmission MAC protocol for WSNs

Duty cycling (DC) has been proven to be an efficient mechanism to reduce energy consumption in wireless sensor networks (WSNs). On the other hand, cooperative transmission (CT) enables longer range transmission to hop over an energy-hole node, resulting in more balanced energy consumption among nodes. In the literature, there exist few CT MAC protocols for DC operated WSNs and these protocols rely on fixed cycle length. In this paper, we propose a novel variable cycle length protocol, namely asynchronous cooperative transmission medium access control (ACT-MAC), which contains both features of reducing the unnecessary idle listening by DC and mitigating the energy-hole by making use of CT. The proposed protocol employs a pseudo random sequence (PRS) generator to produce the variable length cycles. Numerical results show the ACT-MAC protocol's superiority over the existing protocols in terms of network longevity and the energy efficiency.
Reducing BDD Size by Exploiting Functional Dependencies

Many researchers have reported that the use of Boolean decision diagrams (BDDs) greatly increases the size of hardware designs that can be formally verified automatically. Our own experience with automatic verification of high-level aspects of hardware design, such as protocols for cache coherence and communications, contradicts previous results; in fact, BDDs have been substantially inferior to brute-force algorithms that store states explicitly in a table. We believe that new techniques will be needed to realize the potential advantages of BDD verification at the protocol level. Here, we identify functionally dependent variables as a common cause of BDD-size blowup, and describe new techniques to avoid the problem. Using the improved algorithm, we reduce an exponentially-sized problem to a provably O(n log n)-sized one, achieving several orders of magnitude reduction in BDD size.
Generation Z’s Sustainable Volunteering: Motivations, Attitudes and Job Performance

Generation Z (Gen Z), the future of America’s workforce, is forecasted to represent more than 30 million persons by 2020. Volunteer rates have been declining since 2002. Most compelling is that overall lowest volunteer rates were found to be within the Gen Z segment, with expectations of continued decline. Thus, this study explored motivations associated with sustainable volunteering by Gen Z based upon past research that documented intent to volunteer is strongly associated with age. In doing so, the Volunteer Functions Inventory was adopted to identify Gen Z motivations for volunteering. This study then employed the theory of planned behavior to test the relationships between Gen Z volunteering motivations, their attitudes and job performance using data obtained from 306 Gen Z volunteer special event participants. Among five motives identified to be important to Gen Z, only four motives (“value”, “career”, “learning” and “self-esteem”) were found to significantly influence their attitudes. The ‘social’ motive was found to have no significant effect on their attitudes towards volunteering. This research framework was supported by validating the significant relationships between volunteer motivations, attitudes and job performance specific to the Gen Z volunteer segment. “Job training appropriateness” was found to be an important moderator for improving the relationships between Gen Z volunteer attitudes and job performance.
The Critical Role of Epithelial-Derived Act1 in IL-17- and IL-25-Mediated Pulmonary Inflammation1

IL-25 initiates, promotes, and augments Th2 immune responses. In this study, we report that Act1, a key component in IL-17-mediated signaling, is an essential signaling molecule for IL-25 signaling. Although Act1-deficient mice showed reduced expression of KC (CXCL1) and neutrophil recruitment to the airway compared with wild-type mice in response to IL-17 stimulation, Act1 deficiency abolished IL-25-induced expression of IL-4, IL-5, IL-13, eotaxin-1 (CCL11), and pulmonary eosinophilia. Using a mouse model of allergic pulmonary inflammation, we observed diminished Th2 responses and lung inflammation in Act1-deficient mice compared with wild-type mice. Importantly, Act1 deficiency in epithelial cells reduced the phenotype of allergic pulmonary inflammation due to loss of IL-17-induced neutrophilia and IL-25-induced eosinophilia, respectively. These results demonstrate the essential role of epithelial-derived Act1 in allergic pulmonary inflammation through the distinct impact of the IL-17R-Act1 and IL-25R-Act1 axes. Such findings are crucial for the understanding of pathobiology of atopic diseases, including allergic asthma, which identifies Act1 as a potential therapeutic target.
Solubility Enhancement Effect of Cyclodexin on Groundwater Pollutants

Cyclodextrin (CD) molecules are polycyclic glucose oligomers that have a hydrophilic exterior and a hydrophobic cavity. This structure provides CD the characteristic of enhancing the solubility of groundwater pollutants. The degree to which CD increases the apparent aqueous solubility of certain chemicals has been defined as the solubility enhancement factor (SEF). In this study, a novel and experimentally simple method has been developed to determine the SEF, which can be mathematically obtained by ratio of apparent and traditional Henry's law constants. The effects of temperature and CD concentration on the SEFs and CD cavity occupation have been investigated. Our results show that SEF values are inversely related to temperature for most examined chemicals, which is consistent with the assertion that the CD‐chemical complexes are less stable at higher temperatures. The exception is toluene that shows the least SEF fluctuation within the temperature range studied (5 to 65 °C). This may indicate that the toluene‐CD complex is particularly stable. As the definition of SEF predicted, linear relationships were found between the SEFs and CD concentrations for all the subject chemicals. The CD cavity occupation fraction at 5 °C were 3.14, 2.55, 2.04, 1.60, and 1.67 times greater than the values at 65 °C for of trichloroethylene, perchloroethylene, bezene, ethylbenze, and o‐xylene, respectively. The fraction of CD cavities occupied was found to be inversely related to the CD concentration for all tested chemicals when pollutant mass are held constant. This study provides important information to accurately evaluate the performance of CD when used for aquifer remediation.
Line impedance estimation using model based identification technique

The estimation of the line impedance can be used by the control of numerous grid-connected systems, such as active filters, islanding detection techniques, non-linear current controllers, detection of the on/off grid operation mode. Therefore, estimating the line impedance can add extra functions into the operation of the grid-connected power converters. This paper describes a quasi-passive method for estimating the line impedance of the distribution electricity network. The method uses the model based identification technique to obtain the resistive and inductive parts of the line impedance. The quasi-passive behaviour of the proposed method comes from the combination of the non-intrusive behaviour of the passive methods with a better accuracy of the active methods. The simulation results reveal the good accuracy of the proposed method.
A Unified Control Strategy for Three-Phase Inverter in Distributed Generation

This paper presents a unified control strategy that enables both islanded and grid-tied operations of three-phase inverter in distributed generation, with no need for switching between two corresponding controllers or critical islanding detection. The proposed control strategy composes of an inner inductor current loop, and a novel voltage loop in the synchronous reference frame. The inverter is regulated as a current source just by the inner inductor current loop in grid-tied operation, and the voltage controller is automatically activated to regulate the load voltage upon the occurrence of islanding. Furthermore, the waveforms of the grid current in the grid-tied mode and the load voltage in the islanding mode are distorted under nonlinear local load with the conventional strategy. And this issue is addressed by proposing a unified load current feedforward in this paper. Additionally, this paper presents the detailed analysis and the parameter design of the control strategy. Finally, the effectiveness of the proposed control strategy is validated by the simulation and experimental results.
Socioeconomic status and health behaviour patterns through adolescence: results from a prospective cohort study in Norway.

BACKGROUND In this paper, we investigate cross-sectional and prospective relationships between various socioeconomic indicators and different health behaviours among boys and girls at ages 13-21, and whether socioeconomic status (SES) is related to changes in health behaviour over time. METHODS The study is based on a 10-year, two-generation prospective cohort study of health and lifestyle factors among a sample of Norwegian adolescents and their parents. Data presented here were collected at the ages of 13 (baseline), 15, 18 and 21. Parental and adolescent reports of socioeconomic factors were assessed along with a number of health-enhancing and health-compromising behaviours, both as single behaviours and as part of health behaviour indices. RESULTS Relatively few significant relationships are observed between parental occupation and adolescents' reported health behaviour when the latter is analysed as single behaviours. A significant, but weak, social gradient in health-enhancing behaviour is observed when measuring health behaviour as composite indices rather than single forms of behaviour. This is apparent both when applying parental SES variables or adolescents' own educational aspirations as proxy measures of their socioeconomic status. CONCLUSION Future investigations of the presence of a social gradient in adolescent health behaviour should focus on composite measures of health behaviour. Further research is needed on potential mediating mechanisms behind the SES-health behaviour relationships in youth.
Statistical process control for large scale microarray experiments

MOTIVATION Maintaining and controlling data quality is a key problem in large scale microarray studies. In particular systematic changes in experimental conditions across multiple chips can seriously affect quality and even lead to false biological conclusions. Traditionally the influence of these effects can be minimized only by expensive repeated measurements, because a detailed understanding of all process relevant parameters seems impossible. RESULTS We introduce a novel method for microarray process control that estimates quality based solely on the distribution of the actual measurements without requiring repeated experiments. A robust version of principle component analysis detects single outlier microarrays and thereby enables the use of techniques from multivariate statistical process control. In particular, the T(2) control chart reliably tracks undesired changes in process relevant parameters. This can be used to improve the microarray process itself, limits necessary repetitions to only affected samples and therefore maintains quality in a cost effective way. We prove the power of the approach on 3 large sets of DNA methylation microarray data.
The Effect of Preparation Design on the Fracture Resistance of Zirconia Crown Copings (Computer Associated Design/Computer Associated Machine, CAD/CAM System)

Objective One of the major problems of all ceramic restorations is their probable fracture against the occlusal force. The aim of the present in-vitro study is was to compare the effect of two marginal designs (chamfer & shoulder) on the fracture resistance of zirconia copings, CERCON (CAD/CAM). MATERIALS AND METHODS This in vitro study was done with single blind experimental technique. One stainless steel dye with 50′ chamfer finish line design (0.8 mm depth) was prepared using milling machine. Ten epoxy resin dyes were made, The same dye was retrieved and 50′ chamfer was converted into shoulder (1 mm). again ten epoxy resin dyes were made from shoulder dyes. Zirconia cores with 0.4 mm thickness and 35 μm cement Space fabricated on the 20 epoxy resin dyes (10 samples chamfer and 10 samples shoulder) in a dental laboratory. Then the zirconia cores were cemented on the epoxy resin dyes and underwent a fracture test with a universal testing machine (GOTECH AI-700LAC, Arson, USA) and samples were investigated from the point of view of the origin of the failure. RESULT The mean value of fracture resistance for shoulder margins were 788.90±99.56 N and for the chamfer margins were 991.75±112.00 N. The student’s T-test revealed a statistically significant difference between groups (P=0.001). CONCLUSION The result of this study indicates that marginal design of the zirconia cores effects on their fracture resistance. A chamfer margin could improve the biomechanical performance of posterior single zirconia crown restorations. This may be because of strong unity and round internal angle in chamfer margin.
Professional Desires and Career Decisions: Effects of Professional Interests, Role Models, and Internship in Lower Secondary School

Context: Following the social cognitive career theory of Lent, Brown, and Hackett (1994), the current study examines the effect of role models’ professions and practical internship experiences on the choice of professional environment independent of professional interests. Embedded in the Swiss context with its strong vocational training system, the paper outlines to what extent the desired professional environment is realized in the chosen apprenticeship two years later and how this realization can be predicted. The theoretical model proposes that students form direct professional experiences during their first internship(s). If those experiences are positive, students choose an apprenticeship in the same professional environment. Students have indirect (vicarious) professional experiences through their role models. If those experiences are positive, students choose an apprenticeship in the role model’s professional environment. The study examined whether, independent of professional interests, direct experiences in internships and indirect experiences through role models’ professions predict the realization of a desired professional environment in an apprenticeship.Method: The longitudinal sample consists of N = 348 seventh- and ninth-grade students from four German-speaking Swiss cantons. Professional interests and environments were measured using standardized questionnaires. The professional environments of the desired professions, the chosen apprenticeships, the role model’s professions, and the internship’s professions were coded using Holland’s (1997) interest types: realistic, investigative, artistic, social, enterprising, and conventional (RIASEC). Results: In 53% of the cases, students chose an apprenticeship in the professional environment they desired. In 53% of the cases, the chosen professional environment corresponded with the professional environment of the student’s two most important role models. In 39% of the cases, those role models were their parents. By means of logistic regression analyses, we can show that role models’ professional environments and the professional environment of the first internship influenced the realization of the desired professional environment at the end of lower secondary school, independent of the effect of the individuals’ interests.Conclusions: Results show that direct professional experiences in internships and indirect experiences of role models influence the realization of the desired professional environment, independent of professional interests. In a contextual approach, career counselling should include the role model’s profession and how it corresponds with the client’s interests and professional desires. Moreover, role models, especially parents, have a responsibility to reflect on how their goals influence students’ career choice processes.
Greenspan and The Greenbook Robert

A vast literature has emerged using Taylor rules to analyze monetary policy. Although very attractive both theoretically and empirically, such rules imply a mechanical response by the policy variable to fundamental ones. This study looks for empirical evidence of a more sophisticated monetary policy, one which takes into account expected future developments. An important piece of information I use is the Greenbook forecast series, which are calculated by the Federal Reserve Board’s Research Department prior to the Board meetings. Using Greenbook forecasts allows calculation of future inflation shocks as expected by the Fed. These shocks are significant in the estimated Taylor rule, confirming that policymaking is forward-looking. In addition, using Greenbook forecasts allows one to obtain better real time estimates of the potential output, and thus to obtain a more precise characterization of monetary policy.