Miracle-dz/UniFAR-FTUs huggingface dataset:
Different Responses to Reward Comparisons by Three Primate Species

Background Recently, much attention has been paid to the role of cooperative breeding in the evolution of behavior. In many measures, cooperative breeders are more prosocial than non-cooperatively breeding species, including being more likely to actively share food. This is hypothesized to be due to selective pressures specific to the interdependency characteristic of cooperatively breeding species. Given the high costs of finding a new mate, it has been proposed that cooperative breeders, unlike primates that cooperate in other contexts, should not respond negatively to unequal outcomes between themselves and their partner. However, in this context such pressures may extend beyond cooperative breeders to other species with pair-bonding and bi-parental care. Methods Here we test the response of two New World primate species with different parental strategies to unequal outcomes in both individual and social contrast conditions. One species tested was a cooperative breeder (Callithrix spp.) and the second practiced bi-parental care (Aotus spp.). Additionally, to verify our procedure, we tested a third confamilial species that shows no such interdependence but does respond to individual (but not social) contrast (Saimiri spp.). We tested all three genera using an established inequity paradigm in which individuals in a pair took turns to gain rewards that sometimes differed from those of their partners. Conclusions None of the three species tested responded negatively to inequitable outcomes in this experimental context. Importantly, the Saimiri spp responded to individual contrast, as in earlier studies, validating our procedure. When these data are considered in relation to previous studies investigating responses to inequity in primates, they indicate that one aspect of cooperative breeding, pair-bonding or bi-parental care, may influence the evolution of these behaviors. These results emphasize the need to study a variety of species to gain insight in to how decision-making may vary across social structures.
An Accurate Approximation to the Distribution of the Sum of Equally Correlated Nakagami-m Envelopes and Its Application in Equal Gain Diversity Receivers

We present a novel and accurate approximation for the distribution of the sum of equally correlated Nakagami-m variates. Ascertaining on this result we study the performance of Equal Gain Combining (EGC) receivers, operating over equally correlating fading channels. Numerical results and simulations show the accuracy of the proposed approximation and the validity of the mathematical analysis.
Artificial Mangrove Species Mapping Using Pléiades-1: An Evaluation of Pixel-Based and Object-Based Classifications with Selected Machine Learning Algorithms

In the dwindling natural mangrove today, mangrove reforestation projects are conducted worldwide to prevent further losses. Due to monoculture and the low survival rate of artificial mangroves, it is necessary to pay attention to mapping and monitoring them dynamically. Remote sensing techniques have been widely used to map mangrove forests due to their capacity for large-scale, accurate, efficient, and repetitive monitoring. This study evaluated the capability of a 0.5-m Pleiades-1 in classifying artificial mangrove species using both pixel-based and object-based classification schemes. For comparison, three machine learning algorithms—decision tree (DT), support vector machine (SVM), and random forest (RF)—were used as the classifiers in the pixel-based and object-based classification procedure. The results showed that both the pixel-based and object-based approaches could recognize the major discriminations between the four major artificial mangrove species. However, the object-based method had a better overall accuracy than the pixel-based method on average. For pixel-based image analysis, SVM produced the highest overall accuracy (79.63%); for object-based image analysis, RF could achieve the highest overall accuracy (82.40%), and it was also the best machine learning algorithm for classifying artificial mangroves. The patches produced by object-based image analysis approaches presented a more generalized appearance and could contiguously depict mangrove species communities. When the same machine learning algorithms were compared by McNemar’s test, a statistically significant difference in overall classification accuracy between the pixel-based and object-based classifications only existed in the RF algorithm. Regarding species, monoculture and dominant mangrove species Sonneratia apetala group 1 (SA1) as well as partly mixed and regular shape mangrove species Hibiscus tiliaceus (HT) could well be identified. However, for complex and easily-confused mangrove species Sonneratia apetala group 2 (SA2) and other occasionally presented mangroves species (OT), only major distributions could be extracted, with an accuracy of about two-thirds. This study demonstrated that more than 80% of artificial mangroves species distribution could be mapped.
Clinical Staging and Prognostic Factors in Folliculotropic Mycosis Fungoides.

IMPORTANCE Large case series suggest that patients with folliculotropic mycosis fungoides (FMF) have a worse prognosis than patients with classic mycosis fungoides (MF). However, recent studies described a subgroup of patients with FMF with a more favorable prognosis. Distinction between indolent and aggressive FMF may have important therapeutic consequences but is hampered by the inability of the current tumor-node-metastasis-blood (TNMB) staging system to classify patients with FMF in a clinically meaningful way. OBJECTIVE To differentiate between indolent and aggressive FMF using clinicopathological criteria and to define prognostic factors in patients with FMF. DESIGN, SETTING, AND PARTICIPANTS In this prospective cohort study, we followed 203 patients with FMF, included in the Dutch Cutaneous Lymphoma Registry between October 1985 and May 2014 at a tertiary referral center hosting the Dutch Cutaneous Lymphoma Registry. Overall, 220 patients with FMF had been registered, but 17 patients with incomplete follow-up data or a history of classic MF were excluded. MAIN OUTCOMES AND MEASURES Main outcomes included clinical and histological characteristics, disease progression, and survival. Prognostic factors were investigated using Cox proportional hazard regression analysis. Distinction between early plaque-stage FMF and advanced plaque-stage FMF was made by a blinded review of skin biopsy specimens from patients presenting with plaques. RESULTS In a cohort of 147 men and 56 women (median [range] age, 59 [15-93] years), patients with histologically early plaque-stage FMF had a very similar overall survival (OS) rate to patients with only patches and/or follicular papules (10-year OS, 71% vs 80%), while the survival rate of patients with histologically advanced plaque-stage FMF was almost identical to that of patients presenting with tumors (10-year OS, 25% vs 27%). Subsequently, 3 clinical subgroups with significantly different survival data were distinguished: early skin-limited FMF (group A; n = 84; 5-year and 10-year OS, 92% and 72%); advanced skin-limited FMF (group B; n = 102; 5-year and 10-year OS, 55% and 28%); and FMF presenting with extracutaneous disease (group C; n = 17; 5-year and 10-year OS, 23% and 2%). Age at diagnosis, large cell transformation and secondary bacterial infection were independent risk factors for disease progression and/or poor survival. CONCLUSIONS AND RELEVANCE The results of this study provide useful criteria to differentiate between indolent and aggressive FMF and confirm the existence of a subgroup of FMF with a favorable prognosis.
Antitumor Activity of Pembrolizumab in Biomarker-Unselected Patients With Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma: Results From the Phase Ib KEYNOTE-012 Expansion Cohort

Purpose Treatment with pembrolizumab, an anti–programmed death-1 antibody, at 10 mg/kg administered once every 2 weeks, displayed durable antitumor activity in programmed death-ligand 1 (PD-L1) –positive recurrent and/or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC) in the KEYNOTE-012 trial. Results from the expansion cohort, in which patients with HNSCC, irrespective of biomarker status, received a fixed dose of pembrolizumab at a less frequent dosing schedule, are reported. Patients and Methods Patients with R/M HNSCC, irrespective of PD-L1 or human papillomavirus status, received pembrolizumab 200 mg intravenously once every 3 weeks. Imaging was performed every 8 weeks. Primary end points were overall response rate (ORR) per central imaging vendor (Response Evaluation Criteria in Solid Tumors v1.1) and safety. Secondary end points included progression-free survival, overall survival, and association of response and PD-L1 expression. Patients who received one or more doses of pembrolizumab were included in analyses. Results Of 132 patients enrolled, median age was 60 years (range, 25 to 84 years), 83% were male, and 57% received two or more lines of therapy for R/M disease. ORR was 18% (95% CI, 12 to 26) by central imaging vendor and 20% (95% CI, 13 to 28) by investigator review. Median duration of response was not reached (range, ≥ 2 to ≥ 11 months). Six-month progression-free survival and overall survival rates were 23% and 59%, respectively. By using tumor and immune cells, a statistically significant increase in ORR was observed for PD-L1–positive versus –negative patients (22% v 4%; P = .021). Treatment-related adverse events of any grade and grade ≥ 3 events occurred in 62% and 9% of patients, respectively. Conclusion Fixed-dose pembrolizumab 200 mg administered once every 3 weeks was well tolerated and yielded a clinically meaningful ORR with evidence of durable responses, which supports further development of this regimen in patients with advanced HNSCC.
Synura cronbergiae sp. nov., a new species described from two paleogene maar lakes in northern Canada

A new species representing the genus Synura, S. cronbergiae, is described from two Paleogene maar lakes situated near the Arctic Circle in northern Canada. The new taxon is characterized by long, slender, siliceous scales each bearing a small forward projecting spine, a base plate with evenly spaced pores and a secondary layer consisting of hexagonal chambers. Each chamber encloses a base plate pore, opens dorsally via a small pore, and collectively the chambers fuse to form a continuous secondary layer. Although S. cronbergiae is believed most closely related to species in the Sectio Synura due to the presence of a distal spine and lack of a median keel, scales superficially resemble those from a rare species in the Sectio Petersenianae, Synura longisquama. The potential evolutionary history, in the context of the genus, is discussed.
Identifying Trajectories of Change to Improve Understanding of Integrated Health Care Outcomes on PTSD Symptoms Post Disaster

Introduction: Addressing life stressors is an important function for integrated care, especially for health care homes located in disaster prone environments. This study evaluated trajectories of change for patients with postdisaster posttraumatic stress disorder (PTSD) who were seen in integrated care. In addition to describing the results, this article provides the methods of subgroup analyses as this may be useful for others working in real-world practice. Method: Patients (N = 340) receiving services at 5 rural health clinics self-reported PTSD symptoms as part of an ongoing evaluation to study the effectiveness of integrated health. Analysis of variance was used to assess differences overtime and trajectories were identified with cluster analyses. Disaster and trauma related factors associated with these trajectories were assessed using logistic regression. Results: Significant overall decreases in PTSD symptoms overtime were found; individual trajectories were identified and include stable low, steep declines, stable high symptoms, and increasing symptoms. Stress related to disaster and the number of other traumas patients experienced correctly classified trajectory membership. Discussion: Trajectories indicate that patients have differing treatment needs and cluster analysis as an evaluation technique may be useful in identifying what treatment works and for whom. The present study addresses a major concern for health care providers serving disaster prone communities and emphasizes the importance of identifying pre incident and disaster related risk vulnerabilities that contribute to mental health outcomes. Subgroup analyses are a useful tool for developing more targeted treatment within integrated care and may be an accessible research strategy for others working in such settings.
Application of selected reaction monitoring and parallel reaction monitoring for investigation of HL-60 cell line differentiation

Targeted mass spectrometry represents a powerful tool for investigation of biological processes. The convenient approach of selected reaction monitoring using stable isotope-labeled peptide standard (SIS) is widely applied for protein quantification. Along with this method, high-resolution parallel reaction monitoring has been increasingly used for protein targeted analysis. Here we applied two targeted approaches (selected reaction monitoring with SIS and label-free parallel reaction monitoring) to investigate expression of 11 proteins during all-trans retinoic acid-induced differentiation of HL-60 cells. In our experiments, we have determined the proteins expression ratio at 3, 24, 48, and 96 h after all-trans retinoic acid treatment in comparison with 0 h, respectively. Expression profiles of four proteins (VAV1, PRAM1, LYN, and CEBPB) were highly correlated (r > 0.75) and FGR expression was detected on proteome level starting from 24 h by both techniques. For prominent differences (fold change ≥ 2) label-free parallel reaction monitoring is not inferior to selected reaction monitoring with isotopically labeled peptide standards. Differentially expressed proteins, that have been determined in our study, can be considered as potential drug targets for acute myeloid leukemia (AML) treatment.
The Role of Propagule Pressure, Genetic Diversity and Microsite Availability for Senecio vernalis Invasion

Genetic diversity is supposed to support the colonization success of expanding species, in particular in situations where microsite availability is constrained. Addressing the role of genetic diversity in plant invasion experimentally requires its manipulation independent of propagule pressure. To assess the relative importance of these components for the invasion of Senecio vernalis, we created propagule mixtures of four levels of genotype diversity by combining seeds across remote populations, across proximate populations, within single populations and within seed families. In a first container experiment with constant Festuca rupicola density as matrix, genotype diversity was crossed with three levels of seed density. In a second experiment, we tested for effects of establishment limitation and genotype diversity by manipulating Festuca densities. Increasing genetic diversity had no effects on abundance and biomass of S. vernalis but positively affected the proportion of large individuals to small individuals. Mixtures composed from proximate populations had a significantly higher proportion of large individuals than mixtures composed from within seed families only. High propagule pressure increased emergence and establishment of S. vernalis but had no effect on individual growth performance. Establishment was favoured in containers with Festuca, but performance of surviving seedlings was higher in open soil treatments. For S. vernalis invasion, we found a shift in driving factors from density dependence to effects of genetic diversity across life stages. While initial abundance was mostly linked to the amount of seed input, genetic diversity, in contrast, affected later stages of colonization probably via sampling effects and seemed to contribute to filtering the genotypes that finally grew up. In consequence, when disentangling the mechanistic relationships of genetic diversity, seed density and microsite limitation in colonization of invasive plants, a clear differentiation between initial emergence and subsequent survival to juvenile and adult stages is required.
Full length RTN3 regulates turnover of tubular endoplasmic reticulum via selective autophagy

The turnover of endoplasmic reticulum (ER) ensures the correct biological activity of its distinct domains. In mammalian cells, the ER is degraded via a selective autophagy pathway (ER-phagy), mediated by two specific receptors: FAM134B, responsible for the turnover of ER sheets and SEC62 that regulates ER recovery following stress. Here, we identified reticulon 3 (RTN3) as a specific receptor for the degradation of ER tubules. Oligomerization of the long isoform of RTN3 is sufficient to trigger fragmentation of ER tubules. The long N-terminal region of RTN3 contains several newly identified LC3-interacting regions (LIR). Binding to LC3s/GABARAPs is essential for the fragmentation of ER tubules and their delivery to lysosomes. RTN3-mediated ER-phagy requires conventional autophagy components, but is independent of FAM134B. None of the other reticulon family members have the ability to induce fragmentation of ER tubules during starvation. Therefore, we assign a unique function to RTN3 during autophagy. DOI: http://dx.doi. org/10.7554/eLife.25555. 001
Incorporation of Fe3O4 Nanoparticles as Drilling Fluid Additives for Improved Drilling Operations

A successful drilling operation requires an effective drilling fluid system. Due to the variety of downhole conditions across the globe, the fluid system should be designed to meet complex challenges such as High-Pressure/High-Temperature (HPHT) environments, while promoting better productivity with a minimum interference for completion operations. This study aims to improve the rheological and fluid loss properties of water-bentonite suspensions by using both commercial (C-NP) and custom-made (CM-NP) iron oxide (Fe3O4) nanoparticles (NP) as drilling fluid additives. Superparamagnetic Fe3O4 NP were synthesized by the coprecipitation method. Both types of nanoparticles were characterized by a High Resolution Transmission Electron Microscope (TEM) and X-ray Diffraction (XRD). Base fluid (BF), made of deionized water and bentonite at 7wt%, was prepared according to American Petroleum Institute (API) procedures and nanoparticles were added at 0.5 wt%. A Couettetype viscometer was used to analyze the rheological characteristics of these fluids at different shear rates and various temperatures (up to 158oF). The rheological parameters were obtained from analysis of viscometric data using non-linear regression. The API Low-Pressure/Low-Temperature (LPLT) and HPHT fluid filtrate volumes were measured, using a standard API LPLT static filter press (100 psi, 77oF) and an API HPHT filter press (300 psi, 250oF). Observation of the porous matrix morphology of the produced filter cakes was done with Scanning Electron Microscope (SEM). TEM showed that the mean diameter of the CM-NP was 7-8 nm, with measured surface ASME International Conference on Offshore Mechanics and Arctic Engineering, Volume 8: Polar and Arctic Sciences and Technology; Petroleum Technology (): V008T11A040. OMAE2016-54071 2016, June Abstract
Fresh and hardened properties of green binder concrete containing marble powder and brick powder

This article discusses the use of high per cent by-products (i.e. marble powder, brick powder) in green concrete to develop a procedure which construction industry can use. This current study, therefore, uses marble powder and brick powder, crushed aggregate, CEM I 42.5N cement, and tap water for preparing green concrete. Overall substitution rate is maximum 40% in green concrete. Experimented properties are the rheology for fresh state of green concrete, SEM monitoring for hydration growth of cement paste, measuring the strength gains and the projection properties for hardened state of green concrete at 7, 14, 28 and 90 days. Results support this novel conclusion that a marginal increase for the experimented properties of green binder concrete is due to the substitution of marble powder and brick powder for fine aggregate and cement.
Race, Adolescent Binge Drinking, and the Context of Neighborhood Exposure

ABSTRACT Drawing on theories of social structure and normative exposure, we examine how the neighborhood context of socioeconomic advantage and racial composition affects race/ethnic differences in youth binge drinking. Using data from Waves 1 and 2 of the National Longitudinal Study of Adolescent to Adult Health, logistic regressions reveal significant racial differences, with whites having higher odds of binge drinking than other groups. We also find that neighborhood advantage and racial composition have moderating effects on binge drinking; black youths’ odds of binge drinking are significantly lower than whites’ odds in highly advantaged neighborhoods, and Hispanics living in racially integrated neighborhoods have significantly lower odds of binge drinking than Hispanics living in white neighborhoods.
(p,p)-Galois representations attached to automorphic forms on GLn

We study the local reducibility at p of the p-adic Galois representation attached to a cuspidal automorphic representation of GLn(AQ). In the case that the underlying Weil-Deligne representation is Frobenius semisimple and indecomposable, we analyze the reducibility completely. We use methods from p-adic Hodge theory, and work under a transversality assumption on the Hodge and Newton filtrations in the corresponding filtered module.
LC-QTOF-MS Analysis and Activity Profiles of Popular Antioxidant Dietary Supplements in Terms of Quality Control

The dietary supplements with claimed antioxidant activity constitute a substantial part of the dietary supplement market. In this study, we performed the LC-QTOF-MS analysis and investigated the activity profiles of popular antioxidant dietary supplements from different chemical groups in terms of quality control. The commonly used antioxidant tests and statistical analysis revealed that substantial part of the results was comparable if 1 g sample was considered, but while comparing single and daily doses, significant differences in antioxidant values were noticed in all assays. The best antioxidant activity was obtained in ORAC assay (from 142 to 13814 μM of Trolox equivalents per 1 g of sample), and the strongest correlation occurred between TPC and ORAC. The LC-QTOF-MS analysis revealed that catechins were present in samples having the best antioxidant activity and that dietary supplements showing the weakest activity contained very small amount of any chemical constituents.