Miracle-dz/UniFAR-FTUs huggingface dataset:
Meshflow video denoising

We propose an efficient video denoising approach that produces clean videos by utilizing the recently proposed meshflow motion model for the camera motion compensation. The meshflow is a spatially-smooth sparse motion field with motion vectors located at the mesh vertexes. The model is very effective and efficient for the purpose of the multiframes denoising due to its internal characteristics such as the lightweight, the nonparametric form, and the spatially-variant motion representation. Specifically, the meshflows are estimated between adjacent frames, which are used to align frames within a sliding time window. A denoised frame is generated by fusing of several registered frames in a spatial and temporal manner with outlier rejections. Various challenging examples demonstrate the effectiveness and practicability of the proposed approach.
Benthic grazing in a eutrophic river: cascading effects of zoobenthivorous fish mask direct effects of herbivorous fish

Benthic grazing strongly controls periphyton biomass. The question therefore arises whether benthic grazing could be used as a tool to reduce excessive growth of periphyton in nutrient-enriched rivers. Although benthic invertebrate grazers reduce the growth of periphyton, this is highly context dependent. Here we assessed whether the only obligate herbivorous fish in European rivers, the common nase (Chondrostoma nasus L.), is able to reduce periphyton biomass in a eutrophic river. We conducted three consecutive in situ experiments at low, intermediate and high densities of nase in the river using standard tiles on the river bottom naturally covered with periphyton that were accessible to fish and tiles that excluded fish foraging with electric exclosures. The biomass of benthic invertebrate grazers was very low relative to nase. We hypothesised that nase would reduce periphyton biomass on accessible tiles and therefore expected higher periphyton biomass on the exclosure tiles, at least at intermediate and high densities of nase in the river. Contrary to our expectation, the impact of fish grazing was low even at high fish density, as judged by the significantly lower chlorophyll a concentration on exclosure tiles even though the ash-free dry mass on accessible and exclosure tiles did not differ. The lower chlorophyll a concentrations on exclosure tiles might be explained by a higher biomass of invertebrate grazers on the exclosure tiles, which would indicate that the effect of invertebrate grazers was stronger than that of herbivorous fish grazers. The high biomass of invertebrate grazers on exclosure tiles likely arose from the exclusion of zoobenthivorous fish, which occur in the river at high densities. The results of our small-scale experiments suggested that cascading top-down effects of zoobenthivorous fish have a higher impact on periphyton biomass than direct effects of herbivorous nase.
Convergent Actor-Critic Algorithms Under Off-Policy Training and Function Approximation

We present the first class of policy-gradient algorithms that work with both state-value and policy function-approximation, and are guaranteed to converge under off-policy training. Our solution targets problems in reinforcement learning where the action representation adds to the-curse-of-dimensionality; that is, with continuous or large action sets, thus making it infeasible to estimate state-action value functions (Q functions). Using state-value functions helps to lift the curse and as a result naturally turn our policy-gradient solution into classical Actor-Critic architecture whose Actor uses state-value function for the update. Our algorithms, Gradient Actor-Critic and Emphatic Actor-Critic, are derived based on the exact gradient of averaged state-value function objective and thus are guaranteed to converge to its optimal solution, while maintaining all the desirable properties of classical Actor-Critic methods with no additional hyper-parameters. To our knowledge, this is the first time that convergent off-policy learning methods have been extended to classical Actor-Critic methods with function approximation.
Validity of a Chinese version of the Mini Asthma Quality of Life Questionnaire (MiniAQLQ) and a comparison of completion by patients and relatives

ABSTRACT Objective: To test the psychometric properties of the Chinese version of the Mini Asthma Quality of Life Questionnaire (MiniAQLQ) and to investigate the differences between the MiniAQLQ completed by patients (p-MiniAQLQ) and by their relatives (r-MiniAQLQ). Methods: One hundred and two asthmatic patients and 45 relatives were recruited. The reliability was evaluated using Cronbach's alpha and intraclass correlation coefficient (ICC). The validity of the MiniAQLQ was assessed by comparing it with the Sydney Asthma Quality of Life Questionnaire (AQLQ-S) and lung function measurements. The mean quality of life scores were compared by gender and smoking history, and the p-MiniAQLQ scores were then compared with the r-MiniAQLQ scores. Results: The MiniAQLQ showed high internal consistency (Cronbach's alpha = 0.901) and a high two-week reproducibility (ICC = 0.863). The cross-sectional correlations between the MiniAQLQ and the AQLQ-S were strong. Correlations between the MiniAQLQ and lung function (predicted FEV1% and PEF) ranged from poor to weak at the total or domain levels. The MiniAQLQ scores were not significantly associated with gender or smoking history. There was poor agreement between the p-MiniAQLQ and r-MiniAQLQ scores at the total or domain levels. Conclusions: The Chinese version of the MiniAQLQ showed good reliability and validity. It is reliable for evaluating the impact of asthma on patients’ quality of life. Relatives of the patients did not have a comprehensive grasp of the patients’ conditions. Physicians should be cautious when patients’ relatives come to the hospital to seek a modified treatment when the patients are not present.
City Research Online

This paper describes an exploratory study into the accessibility of the virtual world Second Life for two young people with aphasia. Aphasia is a communicative disorder most commonly caused by a stroke. It affects both written and spoken language, is frequently accompanied by right-sided paralysis and people with aphasia can experience isolation and social exclusion. Multi-user virtual worlds are a potential source of fun and contact with others, but how accessible are such worlds to those with communication issues? We report an investigation into the accessibility and potential of Second Life for people with aphasia. This was accomplished through a critique and an empirical study involving two young people: Ann was in her mid twenties and Bob in his early thirties. They were selected because both were comfortable with computer technologies before their strokes and each continues to use them, albeit in a more limited capacity. We discuss implications of the results for people with aphasia interacting with multi-user virtual worlds.
Agentic and communal narcissism and satisfaction with life: The mediating role of psychological entitlement and self‐esteem

This study examined the mediational role of self-esteem (as an enhancement) and psychological entitlement (as a cost) in the relationship between an agentic-communal model of grandiose narcissism and satisfaction with life. Two hundred and forty-eight university undergraduate students completed measures of agentic and communal narcissism, self-esteem, psychological entitlement and satisfaction with life. The findings suggest that there is support for the usefulness of the agentic-communal model of narcissism, and, consistent with predictions in the wider literature, self-esteem and psychological entitlement mediated the relationship between agentic-communal narcissism and life satisfaction.
Systemic Inflammation and Lung Function Impairment in Morbidly Obese Subjects with the Metabolic Syndrome

Background. Obesity and asthma are associated. There is a relationship between lung function impairment and the metabolic syndrome. Whether this relationship also exists in the morbidly obese patients is still unknown. Hypothesis. Low-grade systemic inflammation associated with the metabolic syndrome causes inflammation in the lungs and, hence, lung function impairment. Methods. This is cross-sectional study of morbidly obese patients undergoing preoperative screening for bariatric surgery. Metabolic syndrome was assessed according to the revised NCEP-ATP III criteria. Results. A total of 452 patients were included. Patients with the metabolic syndrome (n = 293) had significantly higher blood monocyte (mean 5.3 versus 4.9, P = 0.044) and eosinophil percentages (median 1.0 versus 0.8, P = 0.002), while the total leukocyte count did not differ between the groups. The FEV1/FVC ratio was significantly lower in patients with the metabolic syndrome (76.7% versus 78.2%, P = 0.032). Blood eosinophils were associated with FEV1/FVC ratio (adj. B −0.113, P = 0.018). Conclusion. Although the difference in FEV1/FVC ratio between the groups is relatively small, in this cross-sectional study, and its clinical relevance may be limited, these data indicate that the presence of the metabolic syndrome may influence lung function impairment, through the induction of relative eosinophilia.
Analysis of DAC MAC RBAC Access Control based Models for Security

Access Control is the process or mechanism for giving the authority to access the specific resources, applications and system. Access control defines a set of conditions or criteria to access the system and its resources. There are three main accesses Control model first is Mandatory access control model, second is Discretionary access control model and third is Role based access control models. In Mandatory access control models, the user&apos;s roles are allotted according to the system administrator wishes. In this, end users do not have authority to set any access control policies on files therefore it is the most restrictive access control method. It is useful in a highly secured environment. For example military, research centers. In Discretionary access control model, the end users have complete authority to assign any rights to objects. But giving all control to the user over the files is too dangerous because if an
DA‐9701 improves colonic transit time and symptoms in patients with functional constipation: A prospective study

DA‐9701, a newly developed prokinetic agent formulated with Pharbitis Semen and Corydalis Tuber, has been shown to effectively treat functional dyspepsia. Recently, it has also been suspected to improve gastrointestinal motor function. The aims of this study were to assess the effect of DA‐9701 on colonic transit time (CTT) and symptoms of functional constipation.
Different Internalization Properties of the α1a- and α1b-Adrenergic Receptor Subtypes: The Potential Role of Receptor Interaction with β-Arrestins and AP50

The internalization properties of the α1a- and α1b-adrenergic receptors (ARs) subtypes transiently expressed in human embryonic kidney (HEK) 293 cells were compared using biotinylation experiments and confocal microscopy. Whereas the α1b-AR displayed robust agonist-induced endocytosis, the α1a-AR did not. Constitutive internalization of the α1a-AR was negligible, whereas the α1b-AR displayed significant constitutive internalization and recycling. We investigated the interaction of the α1-AR subtypes with β-arrestins 1 and 2 as well as with the AP50 subunit of the clathrin adaptor complex AP2. The results from both coimmunoprecipitation experiments and β-arrestin translocation assays indicated that the agonistinduced interaction of the α1a-AR with β-arrestins was much weaker than that of the α1b-AR. In addition, the α1a-AR did not bind AP50. The α1b-AR mutant M8, lacking the main phosphorylation sites in the receptor C tail, was unable to undergo endocytosis and was profoundly impaired in binding β-arrestins despite its binding to AP50. In contrast, the α1b-AR mutant ΔR8, lacking AP50 binding, bound β-arrestins efficiently, and displayed delayed endocytosis. RNA interference showed that β-arrestin 2 plays a prominent role in α1b-AR endocytosis. The findings of this study demonstrate differences in internalization between the α1a- and α1b-AR and provide evidence that the lack of significant endocytosis of the α1a-AR is linked to its poor interaction with β-arrestins as well as with AP50. We also provide evidence that the integrity of the phosphorylation sites in the C tail of the α1b-AR is important for receptor/β-arrestin interaction and that this interaction is the main event triggering receptor internalization.
Overcoming Indecision by Changing the Decision Boundary

The dominant theoretical framework for decision making asserts that people make decisions by integrating noisy evidence to a threshold. It has recently been shown that in many ecologically realistic situations, decreasing the decision boundary maximizes the reward available from decisions. However, empirical support for decreasing boundaries in humans is scant. To investigate this problem, we used an ideal observer model to identify the conditions under which participants should change their decision boundaries with time to maximize reward rate. We conducted 6 expanded-judgment experiments that precisely matched the assumptions of this theoretical model. In this paradigm, participants could sample noisy, binary evidence presented sequentially. Blocks of trials were fixed in duration, and each trial was an independent reward opportunity. Participants therefore had to trade off speed (getting as many rewards as possible) against accuracy (sampling more evidence). Having access to the actual evidence samples experienced by participants enabled us to infer the slope of the decision boundary. We found that participants indeed modulated the slope of the decision boundary in the direction predicted by the ideal observer model, although we also observed systematic deviations from optimality. Participants using suboptimal boundaries do so in a robust manner, so that any error in their boundary setting is relatively inexpensive. The use of a normative model provides insight into what variable(s) human decision makers are trying to optimize. Furthermore, this normative model allowed us to choose diagnostic experiments and in doing so we present clear evidence for time-varying boundaries.
Upper airway and skin symptoms in allergic and non-allergic asthma: Results from the Swedish GA2LEN study

ABSTRACT Background: Allergic and non-allergic asthma are viewed as separate entities, despite sharing similarities. The aims of this study were to determine differences in symptoms from the upper airways and the skin in allergic and non-allergic asthma. The secondary aims were to identify childhood risk factors and to compare quality of life in the two asthma groups. Methods: This cohort (age 17–76 years) consisted of 575 subjects with allergic or non-allergic asthma and 219 controls. The participants participated in an interview, spirometry, FeNO, skin prick test, and responded to the Mini Asthma Quality of Life Questionnaire. Results: Self-reported allergic rhinitis was significantly more common in both allergic and non-allergic asthma (82.3 and 40.7%) groups compared with the controls. The prevalence of chronic rhinosinusitis (CRS) was similar in both asthma groups. Eczema was significantly more common in both asthmatic groups (72.3 and 59.8%) than controls (47.0%) (p < 0.001 and p = 0.012). Severe respiratory infection in childhood and parental allergy were risk factors for both allergic and non-allergic asthma groups. Quality of life was significantly lower in non-allergic than allergic asthma groups (p = 0.01). Conclusion: Concomitant symptoms from the upper airways and the skin were significantly more common in both allergic and non-allergic asthma. This indicates that non-allergic asthma has a systemic component with similarities to what is found in allergic asthma. There were similarities in the childhood risk factor pattern between the two types of asthma but asthma-related quality of life was lower in the non-allergic asthma group.
Utilizing Chimeric Antigen Receptors to Direct Natural Killer Cell Activity

Natural killer (NK) cells represent an attractive lymphocyte population for cancer immunotherapy due to their ability to lyse tumor targets without prior sensitization and without need for human leukocyte antigens-matching. Chimeric antigen receptors (CARs) are able to enhance lymphocyte targeting and activation toward diverse malignancies. CARs consist of an external recognition domain (typically a small chain variable fragment) directed at a specific tumor antigen that is linked with one or more intracellular signaling domains that mediate lymphocyte activation. Most CAR studies have focused on their expression in T cells. However, use of CARs in NK cells is starting to gain traction because they provide a method to redirect these cells more specifically to target refractory cancers. CAR-mediated anti-tumor activity has been demonstrated using NK cell lines, as well as NK cells isolated from peripheral blood, and NK cells produced from human pluripotent stem cells. This review will outline the CAR constructs that have been reported in NK cells with a focus on comparing the use of different signaling domains in combination with other co-activating domains.
CRISPR-Cas9 vectors for genome editing and host engineering in the baculovirus–insect cell system

Significance CRISPR-Cas9 is a powerful site-specific genome-editing tool that has been used to genetically engineer many different systems. However, this tool has not yet been adopted for use in the baculovirus–insect cell system, which is an important recombinant protein production platform. Thus, we created new CRISPR-Cas9 vectors that can be used for genome editing in two relevant insect cell lines. This is significant because these tools will enable new efforts to enhance the capabilities and expand the utility of this important protein production platform. The baculovirus–insect cell system (BICS) has been widely used to produce many different recombinant proteins for basic research and is being used to produce several biologics approved for use in human or veterinary medicine. Early BICS were technically complex and constrained by the relatively primordial nature of insect cell protein glycosylation pathways. Since then, recombination has been used to modify baculovirus vectors—which has simplified the system—and transform insect cells, which has enhanced its protein glycosylation capabilities. Now, CRISPR-Cas9 tools for site-specific genome editing are needed to facilitate further improvements in the BICS. Thus, in this study, we used various insect U6 promoters to construct CRISPR-Cas9 vectors and assessed their utility for site-specific genome editing in two insect cell lines commonly used as hosts in the BICS. We demonstrate the use of CRISPR-Cas9 to edit an endogenous insect cell gene and alter protein glycosylation in the BICS.
Fabrication of Titania Nanofibers by Electrospinning

This paper describes a procedure based on electrospinning for generating nanofibers of anatase with controllable diameters and porous structures. When an ethanol solution containing both poly(vinyl pyrrolidone) (PVP, Mw ≈ 1 300 000) and titanium tetraisopropoxide was injected through a needle under a strong electrical field, composite nanofibers made of PVP and amorphous TiO2 were formed (with lengths up to several centimeters) as a result of electrostatic jetting. These nanofibers could be subsequently converted into anatase without changing their morphology via calcination in air at 500 °C. The average diameter of these ceramic nanofibers could be controlled in the range from 20 to 200 nm by varying a number of parameters such as the ratio between PVP and titanium tetraisopropoxide, their concentrations in the alcohol solution, the strength of the electric field, and the feeding rate of the precursor solution. Both supported and free-standing mats consisting of anatase nanofibers have been successfully .
Fatigue Crack Growth During Gross Plasticity and the J-Integral

An attempt is made to apply the J-integral concept as an elastic-plastic criterion for fatigue crack growth. Compact tension fracture specimens of A533B steel are subjected to gross cyclic plastic deformations, and fatigue crack growth rates up to 0.01 in. /cycle are obtained. The results show correlation with J-integral values estimated from load versus deflection hysteresis loops. Also, agreement is obtained with the extrapolation of linear elastic fatigue crack growth rate data.
A new humanized in vivo model of KIT D816V+ advanced systemic mastocytosis monitored using a secreted luciferase

Systemic mastocytosis are rare neoplasms characterized by accumulation of mast cells in at least one internal organ. The majority of systemic mastocytosis patients carry KIT D816V mutation, which activates constitutively the KIT receptor. Patient with advanced forms of systemic mastocytosis, such as aggressive systemic mastocytosis or mast cell leukemia, are poorly treated to date. Unfortunately, the lack of in vivo models reflecting KIT D816V+ advanced disease hampers pathophysiological studies and preclinical development of new therapies for such patients. Here, we describe a new in vivo model of KIT D816V+ advanced systemic mastocytosis developed by transplantation of the human ROSAKIT D816V-Gluc mast cell line in NOD-SCID IL-2R g−/− mice, using Gaussia princeps luciferase as a reporter. Intravenous injection of ROSAKIT D816V-Gluc cells led, in 4 weeks, to engraftment in all injected primary recipient mice. Engrafted cells were found at high levels in bone marrow, and at lower levels in spleen, liver and peripheral blood. Disease progression was easily monitored by repeated quantification of Gaussia princeps luciferase activity in peripheral blood. This quantification evidenced a linear relationship between the number of cells injected and the neoplastic mast cell burden in mice. Interestingly, the secondary transplantation of ROSAKIT D816V-Gluc cells increased their engraftment capability. To conclude, this new in vivo model mimics at the best the features of human KIT D816V+ advanced systemic mastocytosis. In addition, it is a unique and convenient tool to study the kinetics of the disease and the potential in vivo activity of new drugs targeting neoplastic mast cells.