Miracle-dz/UniFAR-FTUs huggingface dataset:
Optimization of routing and wireless resource allocation in hybrid data center networks. (Optimisation du routage et de l'allocation de ressources sans fil dans les réseaux des centres de données hybrides)

L’arrivee de la prochaine technologie 5G va permettre la connectivite des billions de terminaux mobiles et donc une enorme augmentation du trafic de donnees. A cet egard, les fournisseurs des services Cloud doivent posseder les infrastructures physiques capables de supporter cette explosion de trafic. Malheureusement, les architectures filaires conventionnelles des centres de donnees deviennent staturees et la congestion des equipements d’interconnexion est souvent atteinte. Dans cette these, nous explorons une approche recente qui consiste a augmenter le reseau filaire du centre de donnees avec l’infrastructure sans fil. En effet, nous exploitons une nouvelle technologie emergente, la technologie 60 GHz, qui assure un debit de l’ordre de 7 Gbits/s afin d’ameliorer la QoS. Nous concevons une architecture hybride (filaire/sans fil) du reseau de centre de donnees basee sur : i) le modele "Cisco’s Massively Scalable Data Center" (MSDC), et ii) le standard IEEE 802.11ad. Dans une telle architecture, les serveurs sont regroupes dans des racks, et sont interconnectes a travers un switch Ethernet, appele top-of-rack (ToR) switch. Chaque ToR switch possede plusieurs antennes utilisees en parallele sur differents canaux sans fil. L’objectif final consiste a minimiser la congestion du reseau filaire, en acheminant le maximum du trafic sur les canaux sans fil. Pour ce faire, cette these se focalise sur l’optimisation du routage et de l’allocation des canaux sans fil pour les communications inter-rack, au sein d’un centre de donnees hybride (HDCN). Ce probleme etant NP-difficile, nous allons proceder en trois etapes. En premier lieu, on considere le cas des communications a un saut, ou les racks sont places dans le meme rayon de transmission. Nous proposons un nouvel algorithme d’allocation des canaux sans fil dans les HDCN, qui permet d’acheminer le maximum des communications en sans-fil, tout en ameliorant les performances reseau en termes de debit et delai. En second lieu, nous nous adressons au cas des communications a plusieurs sauts, ou les racks ne sont pas dans le meme rayon de transmission. Nous allons proposer une nouvelle approche optimale traitant conjointement le probleme du routage et de l’allocation de canaux sans fils dans le HDCN, pour chaque communication, dans un mode online. En troisieme etape, nous proposons un nouvel algorithme qui calcule conjointement le routage et l’allocation des canaux pour un ensemble des communications arrivant en mode batch (i.e., par lot). En utilisant le simulateur reseau QualNet, considerant toute la pile TCP/IP, les resultats obtenus montrent que nos propositions ameliorent les performances comparees aux methodes de l’etat de l’art
Using portable negative pressure wound therapy devices in the home care setting

: Negative pressure wound therapy (NPWT) is the continuous or intermittent application of subatmospheric pressure to the surface of a wound that improves the wound environment, accelerates healing, and reduces wound closure time. Since its first documented use, this technology has lent itself to a number of adaptations, most notably, the development of portable devices facilitating treatment in the home care setting. With advancing surgical standards, wound healing is an important rate-limiting factor in early patient discharge and often a major cost of inpatient treatment. The efficacy of NPWT in the home care setting has been investigated through rate of wound closure, time in care, and patient experience. Rate of wound closure is the most appropriate primary end point. Much can be gleaned from patient experience, but the future success of portable NPWT will be measured on time in care and therefore cost effectiveness. However, there is a lack of level 1a evidence demonstrating increased efficacy of portable over inpatient NPWT. The development of portable NPWT is an encouraging innovation in wound care technology, and extending the benefits to the home care setting is both possible and potentially more beneficial.
From CDF to PDF - A Density Estimation Method for High Dimensional Data

CDF2PDF is a method of PDF estimation by approximating CDF. The original idea of it was previously proposed in [1] called SIC. However, SIC requires additional hyper-parameter tunning, and no algorithms for computing higher order derivative from a trained NN are provided in [1]. CDF2PDF improves SIC by avoiding the time-consuming hyper-parameter tuning part and enabling higher order derivative computation to be done in polynomial time. Experiments of this method for one-dimensional data shows promising results.
Mineralocorticoid Receptor Antagonism in Patients With Atrial Fibrillation: Findings From the ORBIT‐AF (Outcomes Registry for Better Informed Treatment of Atrial Fibrillation) Registry

Background Mineralocorticoid receptor antagonist (MRA) therapy may be beneficial to patients with atrial fibrillation (AF), but little is known about their use in patients with AF and subsequent outcomes. Methods and Results In order to better understand MRA use and subsequent outcomes, we performed a retrospective cohort study of the contemporary ORBIT‐AF (Outcomes Registry for Better Informed Treatment of Atrial Fibrillation) registry. AF progression and cardiovascular outcomes were compared using propensity‐matched Cox proportional hazards modeling according to MRA use at baseline and new MRA use at follow‐up versus patients with no MRA use. Among 7012 patients with nonpermanent AF, 320 patients were taking MRA at enrollment, and 416 patients initiated MRA use during follow‐up. The mean patient age was 72.5 years, 56.3% were men, and 70.4% had paroxysmal AF. Among all patients taking MRAs, 434 (59.0%) had heart failure, 655 (89.0%) had hypertension, and 380 (51.6%) had both. After adjustment, new MRA use was not associated with reduced AF progression (hazard ratio, 1.18; 95% confidence interval, 0.88–1.58; P=0.27) but showed a trend towards lower risk of stroke, transient ischemic attack, or systemic embolism (hazard ratio, 0.17; 95% confidence interval, 0.02–1.23; P=0.08). Results were similar for a comparison of new MRA users and baseline MRA users compared with nonusers. Conclusions In community‐based outpatients with AF, the majority of MRA use was for heart failure and hypertension. MRA use also trended towards lower adjusted stroke risk. Future studies should test the hypothesis that MRA use may decrease the risk of stroke in patients with AF.
COMPARATIVE STUDY OF PHYSICAL FITNESS PARAMETERS AMONG 12 YEARS OLD RURAL AND URBAN CHILDREN

Background: The environmental factors lead to changes in the physical fitness level among children. The objective of the present study was to compare the physical fitness parameters of the rural and urban children from Punjab. Methods: Total 60 children (30 rural and 30 urban) 12 years old were selected to participate in the study. All the subjects were measured for various physical fitness parameters. The speed ability was measured with the help of 30 meter sprint (Flying Start). The endurance of the rural and urban children was assessed with the help of 800 meter run. Sit and reach test was used to assess the flexibility of the children. The standing broad jump and standing vertical jump were applied to measure the explosive strength. The grip strength was measured with the help of hand dynamometer. The medicine ball put was used to measure the strength of arms. Results: The independent samples t-test revealed that the rural children were found to have significantly greater speed (p<0.05), standing broad jump (p<0.05), grip strength of both left (p<0.05) and right (p<0.05) hand than the urban children. Conclusions: It can be concluded that the rural children were better in some physical fitness parameters. Article visualizations:
The physics of dipolar bosonic quantum gases

This paper reviews the recent theoretical and experimental advances in the study of ultra-cold gases made of bosonic particles interacting via the long-range, anisotropic dipole–dipole interaction, in addition to the short-range and isotropic contact interaction usually at work in ultra-cold gases. The specific properties emerging from the dipolar interaction are emphasized, from the mean-field regime valid for dilute Bose–Einstein condensates, to the strongly correlated regimes reached for dipolar bosons in optical lattices.
The addition of a psychological intervention to a home detoxification programme.

AIMS Home detoxification is a recognized method of treating problem drinkers within their own home environment. The aim of this research is to determine whether a relatively brief psychological intervention adds to its effectiveness. METHODS A pragmatic trial with 91 participants randomly assigned to either the psychological intervention or treatment as usual. Community Psychiatric Nurses were trained to administer the brief psychological intervention involving motivational interviewing, coping skills training and social support. A manual was developed in order to standardize the training and implementation. RESULTS At the 3 month and 12 month follow-up the psychological intervention resulted in significant positive changes in alcohol consumption, abstinent days, social satisfaction, self-esteem and alcohol-related problems. Further, a cost analysis confirmed that the psychological intervention was a ninth of the cost of inpatient treatment. CONCLUSIONS Adding a psychological intervention to a home detoxification programme was successful and cost-effective.
Effects of resveratrol on cerebral blood flow variables and cognitive performance in humans: a double-blind, placebo-controlled, crossover investigation.

BACKGROUND The many putative beneficial effects of the polyphenol resveratrol include an ability to bolster endogenous antioxidant defenses, modulate nitric oxide synthesis, and promote vasodilation, which thereby improves blood flow. Resveratrol may therefore modulate aspects of brain function in humans. OBJECTIVE The current study assessed the effects of oral resveratrol on cognitive performance and localized cerebral blood flow variables in healthy human adults. DESIGN In this randomized, double-blind, placebo-controlled, crossover study, 22 healthy adults received placebo and 2 doses (250 and 500 mg) of trans-resveratrol in counterbalanced order on separate days. After a 45-min resting absorption period, the participants performed a selection of cognitive tasks that activate the frontal cortex for an additional 36 min. Cerebral blood flow and hemodynamics, as indexed by concentration changes in oxygenated and deoxygenated hemoglobin, were assessed in the frontal cortex throughout the posttreatment period with the use of near-infrared spectroscopy. The presence of resveratrol and its conjugates in plasma was confirmed by HPLC after the same doses in a separate cohort (n = 9). RESULTS Resveratrol administration resulted in dose-dependent increases in cerebral blood flow during task performance, as indexed by total concentrations of hemoglobin. There was also an increase in deoxyhemoglobin after both doses of resveratrol, which suggested enhanced oxygen extraction, that became apparent toward the end of the 45-min absorption phase and was sustained throughout task performance. Cognitive function was not affected. Resveratrol metabolites were present in plasma throughout the cognitive task period. CONCLUSION These results showed that single doses of orally administered resveratrol can modulate cerebral blood flow variables.
A Radiographic Study of Non-Syndromic Congenitally Missing Teeth in Permanent Dentition of Nigerian Dental Patients

Congenitally missing permanent teeth was evaluated on orthopantomograms of 611 apparently healthy patients, aged 10 to 25 years at a specialist dental clinic in Lagos, Nigeria. The prevalence of congenitally missing teeth (CMT) including third molars was 7.3% in boys and 10.7% in girls, and 9.3% for both sexes combined. There were in total 57 CMT, and on average 2.1 permanent teeth were missing per child. The most commonly absent tooth was the maxillary lateral incisor (n = 22), followed by equal number of maxillary and mandibular third molars (n = 21), then mandibular second premolars (n = 19). On the other hand, no first and second molars were missing, and there were no cases with oligodontia (6 or more CMT excluding the third molar). Symmetry of CMT was predominant with 43 pairs (72.3%) of bilateral symmetry recorded. The distribution of CMT either between the maxilla and the mandible, or between the right and left quadrant did not show any significant association with sex (P > 0.05).
Testing of several distributed file-systems (HDFS, Ceph and GlusterFS) for supporting the HEP experiments analysis

The activity of testing new storage solution is of great importance in order to provide both features and performance evaluation and give few hints to small-medium sites that are interested in exploiting new storage technologies. In particular this work will cover storage solutions that provide both standard POSIX storage access and cloud technologies; we focused our attention and our test on HDFS, Ceph, and GlusterFS.
The Galactic centre mini-spiral in the mm-regime

Context. The mini-spiral is a feature of the interstellar medium in the central ∼2 pc of the Galactic center. It is composed of several streamers of dust and ionised and atomic gas with temperatures between a few 100 K to 10 4 K. There is evidence that these streamers are related to the so-called circumnuclear disk of molecular gas and are ionized by photons from massive, hot stars in the central parsec. Aims. We attempt to constrain the emission mechanisms and physical properties of the ionized gas and dust of the mini-spiral region with the help of our multiwavelength data sets. Methods. Our observations were carried out at 1.3 mm and 3 mm with the mm interferometric array CARMA in California in March and April 2009, with the MIR instrument VISIR at ESO’s VLT in June 2006, and the NIR Brγ with VLT NACO in August 2009. Results. We present high resolution maps of the mini-spiral, and obtain a spectral index of 0.5 ± 0.25 for Sgr A*, indicating an inverted synchrotron spectrum. We find electron densities within the range 0.8–1.5 × 10 4 cm −3 for the mini-spiral from the radio continuum
From Glacier to Sauna: RNA-Seq of the Human Pathogen Black Fungus Exophiala dermatitidis under Varying Temperature Conditions Exhibits Common and Novel Fungal Response

Exophiala dermatitidis (Wangiella dermatitidis) belongs to the group of the so-called black yeasts. Thanks in part to its thick and strongly melanized cell walls, E. dermatitidis is extremely tolerant to various kinds of stress, including extreme pH, temperature and desiccation. E. dermatitidis is also the agent responsible for various severe illnesses in humans, such as pneumonia and keratitis, and might lead to fatal brain infections. Due to its association with the human environment, its poly-extremophilic lifestyle and its pathogenicity in humans, E. dermatitidis has become an important model organism. In this study we present the functional analysis of the transcriptional response of the fungus at 1°C and 45°C, in comparison with that at 37°C, for two different exposition times, i.e. 1 hour and 1 week. At 1°C, E. dermatitidis uses a large repertoire of tools to acclimatize, such as lipid membrane fluidization, trehalose production or cytoskeleton rearrangement, which allows the fungus to remain metabolically active. At 45°C, the fungus drifts into a replicative state and increases the activity of the Golgi apparatus. As a novel finding, our study provides evidence that, apart from the protein coding genes, non-coding RNAs, circular RNAs as well as fusion-transcripts are differentially regulated and that the function of the fusion-transcripts can be related to the corresponding temperature condition. This work establishes that E. dermatitidis adapts to its environment by modulating coding and non-coding gene transcription levels and through the regulation of chimeric and circular RNAs.
Role of dietary lipids in food allergy

Abstract The prevalence of food allergy is raising in industrialized countries, but the mechanisms behind this increased incidence are not fully understood. Environmental factors are believed to play a role in allergic diseases, including lifestyle influences, such as diet. There is a close relationship between allergens and lipids, with many allergenic proteins having the ability to bind lipids. Dietary lipids exert pro-inflammatory or anti-inflammatory functions on cells of the innate immunity and influence antigen presentation to cells of the adaptive immunity. In addition to modifying the immunostimulating properties of proteins, lipids also alter their digestibility and intestinal absorption, changing allergen bioavailability. This study provides an overview of the role of dietary lipids in food allergy, taking into account epidemiological information, as well as results of mechanistic investigations using in vivo, ex vivo and in vitro models. The emerging link among high-fat diets, obesity, and allergy is also discussed.
Enhancing Prediction Models for One-Year Mortality in Patients with Acute Myocardial Infarction and Post Myocardial Infarction Syndrome

Predicting the risk of mortality for patients with acute myocardial infarction (AMI) using electronic health records (EHRs) data can help identify risky patients who might need more tailored care. In our previous work, we built computational models to predict one-year mortality of patients admitted to an intensive care unit (ICU) with AMI or post myocardial infarction syndrome. Our prior work only used the structured clinical data from MIMIC-III, a publicly available ICU clinical database. In this study, we enhanced our work by adding the word embedding features from free-text discharge summaries. Using a richer set of features resulted in significant improvement in the performance of our deep learning models. The average accuracy of our deep learning models was 92.89% and the average F-measure was 0.928. We further reported the impact of different combinations of features extracted from structured and/or unstructured data on the performance of the deep learning models.
Evidence of increasing drought severity caused by temperature rise in southern Europe

We use high quality climate data from ground meteorological stations in the Iberian Peninsula (IP) and robust drought indices to confirm that drought severity has increased in the past five decades, as a consequence of greater atmospheric evaporative demand resulting from temperature rise. Increased drought severity is independent of the model used to quantify the reference evapotranspiration. We have also focused on drought impacts to drought-sensitive systems, such as river discharge, by analyzing streamflow data for 287 rivers in the IP, and found that hydrological drought frequency and severity have also increased in the past five decades in natural, regulated and highly regulated basins. Recent positive trend in the atmospheric water demand has had a direct influence on the temporal evolution of streamflows, clearly identified during the warm season, in which higher evapotranspiration rates are recorded. This pattern of increase in evaporative demand and greater drought severity is probably applicable to other semiarid regions of the world, including other Mediterranean areas, the Sahel, southern Australia and South Africa, and can be expected to increasingly compromise water supplies and cause political, social and economic tensions among regions in the near future.
Quality of osteoarthritis care in family medicine – A cross-sectional study.

Introduction Effective treatments for osteoarthritis are available, yet little is known about the quality of primary care in the Republic of Srpska for this disabling condition. Objective The main objective of this study was to analyze the overall quality of osteoarthritis treatment in a family medicine setting, as well as to explore whether the achievement of quality indicators was associated with particular patient characteristics and severity of osteoarthritis. Methods The cross-sectional study included 120 patients with confirmed hand, knee, and hip osteoarthritis, recruited at seven family practices in the town of Ugljevik, Republic of Srpska, Bosnia and Herzegovina. Data were extracted from a patient questionnaire on quality indicators, as well as from their electronic and paper records, to assess care against 14 indicators. The included quality indicators were based on the Arthritis Foundation’s Quality Indicator set for Osteoarthritis. Summary achievement rates for hip, knee, or hand osteoarthritis, as well as for the total sample, were calculated. Results The mean achievement rate for all 14 quality indicators obtained from medical records was 74%, and 77% obtained from patient interview. The quality indicators concerning referral for weight reduction (23%) and pharmacological treatment (24%) had the lowest achievement rates, whereas the highest achievement rates were related to physical examination (100%), pain and functional assessment (100%), and education (90.8%). Patients physical functioning was significantly associated with the quality indicator achievement rate (p = 0.001). Conclusion Pharmacological therapy and the referral of osteoarthritis patients in need of weight reduction seem to have the greatest potential for improvement in primary health care.
Misleading conclusions from exogenous ABA application: a cautionary tale about the evolution of stomatal responses to changes in leaf water status

ABSTRACT Stomatal responses to changes in leaf water status are critical for minimizing excessive water loss during soil drought. A major debate has surrounded the evolution of stomatal responses to water status and this debate has particularly focused on the evolution of the regulatory role of the drought hormone abscisic acid (ABA). Studies relying on the application of high levels of exogenous ABA have occasionally concluded that all stomata respond to ABA and that stomatal regulation in response to this hormone has not evolved over the past 450 million years. In contrast, studies which have investigated stomatal function in intact plants, as well as the role of endogenous ABA in regulating stomatal aperture, have found major evolutionary transitions in the functional regulation of stomata across land plant lineages. We show that endogenous ABA plays no role in closing the stomata of the fern Nephrolepis exaltata during natural soil drought, in contrast to a recent finding using isolated epidermis and exceptionally high levels of exogenous ABA. We conclude that stomatal behavior in intact plants has evolved over time, and may have shaped the evolutionary and ecological success of successive land plant lineages.