Miracle-dz/UniFAR-FTUs huggingface dataset:
Analgesic Effects of Bee Venom Derived Phospholipase A2 in a Mouse Model of Oxaliplatin-Induced Neuropathic Pain

A single infusion of oxaliplatin, which is widely used to treat metastatic colorectal cancer, induces specific sensory neurotoxicity signs that are triggered or aggravated when exposed to cold or mechanical stimuli. Bee Venom (BV) has been traditionally used in Korea to treat various pain symptoms. Our recent study demonstrated that BV alleviates oxaliplatin-induced cold allodynia in rats, via noradrenergic and serotonergic analgesic pathways. In this study, we have further investigated whether BV derived phospholipase A2 (bvPLA2) attenuates oxaliplatin-induced cold and mechanical allodynia in mice and its mechanism. The behavioral signs of cold and mechanical allodynia were evaluated by acetone and a von Frey hair test on the hind paw, respectively. The significant allodynia signs were observed from one day after an oxaliplatin injection (6 mg/kg, i.p.). Daily administration of bvPLA2 (0.2 mg/kg, i.p.) for five consecutive days markedly attenuated cold and mechanical allodynia, which was more potent than the effect of BV (1 mg/kg, i.p.). The depletion of noradrenaline by an injection of N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride (DSP4, 50 mg/kg, i.p.) blocked the analgesic effect of bvPLA2, whereas the depletion of serotonin by injecting DL-p-chlorophenylalanine (PCPA, 150 mg/kg, i.p.) for three successive days did not. Furthermore, idazoxan (α2-adrenegic receptor antagonist, 1 mg/kg, i.p.) completely blocked bvPLA2-induced anti-allodynic action, whereas prazosin (α1-adrenegic antagonist, 10 mg/kg, i.p.) did not. These results suggest that bvPLA2 treatment strongly alleviates oxaliplatin-induced acute cold and mechanical allodynia in mice through the activation of the noradrenergic system, via α2-adrenegic receptors, but not via the serotonergic system.
Space and time to engage: mature-aged distance students learn to fit study into their lives

Student engagement, a student’s emotional, behavioural and cognitive connection to their study, is widely recognized as important for student achievement. Influenced by a wide range of personal, structural and sociocultural factors, engagement is both unique and subjective. One important structural factor shown in past research to be a barrier for distance students is access to quality space and time. This qualitative study followed 19 mature-aged distance students and their families, exploring how they learned to manage their space and time throughout their first semester at university. Institutions often claim that distance study and the increased use of technology overcomes barriers of space and time; however, the findings from this study suggest it merely changes the nature of those barriers. The ideal space and time for these students was individual and lay at the intersection of three, sometimes competing, demands: study, self and family. A critical influence on success is family support, as is access to financial resources. Learning what constitutes ideal space and time for engagement is an important part of the transition to university. The institution has a vital role to play in aiding this process by ensuring flexibility of course design is maintained, providing more flexible advice and targeting support at this important issue.
Comparison of metformin, gliclazide MR and rosiglitazone in monotherapy and in combination for type 2 diabetes.

OBJECTIVE To compare the efficacy and tolerability of metformin, rosiglitazone and gliclazide MR as monotherapy and in combination in the treatment of type 2 diabetes. SUBJECTS AND METHODS 250 patients treated with oral antidiabetic agents for at least 24 weeks in monotherapy or in combination therapy were included in this retrospective study. RESULTS As monotherapy the reduction of fasting plasma glucose (FPG), postprandial glycemia (PPG) and HbA1c was similar with the three drugs after 24 weeks. Among patients on combination therapy, the reduction in HbA1c, FPG and PPG was significantly lower with rosiglitazone plus metformin, as compared to metformin plus gliclazide MR or gliclazide MR plus rosiglitazone. Patients treated with rosiglitazone achieved less favorable changes in lipid profile. CONCLUSION In monotherapy all drugs were equally effective in improving glycemic control, whereas the combination of metformin plus gliclazide MR provided the best results concerning the improvement of both, glycemic control and lipid profile.
Use of Brown's 14 Grammatical Morphemes by Bilingual Hispanic Preschoolers

This pilot study investigated Standard American English (SAE) morphological development for 15 bilingual Hispanic preschoolers who were attending a bilingual day care center. Participants included nine girls and six boys between the ages of 2.6 years and 5.0 years (mean age = 3.8 years). Thirty-minute spontaneous language samples were obtained, yielding 100 utterances for mean length of utterance (MLU) and morphological analysis according to Miller's (1981) criteria. Analysis of the data revealed emergent use of Brown's (1973) 14 grammatical morphemes, although mastery generally was not seen at the same ages as those expected for SAE speakers. Clinicians should exercise caution when applying SAE normative data to bilingual Spanish-speaking children.
Validation of a Malay Version of the Smartphone Addiction Scale among Medical Students in Malaysia

Introduction This study was initiated to determine the psychometric properties of the Smart Phone Addiction Scale (SAS) by translating and validating this scale into the Malay language (SAS-M), which is the main language spoken in Malaysia. This study can distinguish smart phone and internet addiction among multi-ethnic Malaysian medical students. In addition, the reliability and validity of the SAS was also demonstrated. Materials and Methods A total of 228 participants were selected between August 2014 and September 2014 to complete a set of questionnaires, including the SAS and the modified Kimberly Young Internet addiction test (IAT) in the Malay language. Results There were 99 males and 129 females with ages ranging from 19 to 22 years old (21.7±1.1) included in this study. Descriptive and factor analyses, intra-class coefficients, t-tests and correlation analyses were conducted to verify the reliability and validity of the SAS. Bartlett’s test of sphericity was significant (p <0.01), and the Kaiser-Mayer-Olkin measure of sampling adequacy for the SAS-M was 0.92, indicating meritoriously that the factor analysis was appropriate. The internal consistency and concurrent validity of the SAS-M were verified (Cronbach’s alpha = 0.94). All of the subscales of the SAS-M, except for positive anticipation, were significantly related to the Malay version of the IAT. Conclusions This study developed the first smart phone addiction scale among medical students. This scale was shown to be reliable and valid in the Malay language.
The resource-based view and economics

This paper analyzes the link between economics and the resource-based view (RBV) of the firm. Although, historically there has been a strong link between the disciplines of strategy and economics, explicit citations of key RBV works has been disappointingly low in mainstream economics journals. However, there are substantial bodies of works that build implicitly on the ideas of the RBV, in particular the consequences of path dependency on firm behavior, to explain a number of different economic issues. The issues we review in the paper are all influenced by path dependency and include: (1) diversification and market entry, (2) corporate refocusing, and market exit, (3) explaining innovative activity among firms, (4) diversification and performance and (5) industry evolution with rapidly changing products. Furthermore, we identify a number of reasons that may have limited the explicit use of the RBV in economics, which include the problems of causal ambiguity, tautology and firm heterogeneity. Finally, potential areas for future research are identified, which include the interaction of the RBV and Agency Theory, the RBV as a dynamic theory, using the RBV to explain radical change and the application of the RBV to issues of antitrust.
Reprodutibilidade de um protocolo de esforço durante a corrida em piscina funda Reproducibility of an effort protocol during deep-water running

The aim of this study was to verify the inter-assessment reproducibility of heart rate (HR) and rating of perceived exertion (RPE) in exercise with different cadences during deep water running. In a comparative and correlational study, twenty physically active college students (aged 21.10 ± 1.68 yr, body mass 68.90 ± 7.24 kg, height 174.60 ± 5.35 cm, Σ7SF 106.80 ± 28.63 mm) were assessed twice by two different evaluators in a 12-stage sub maximal protocol of deep water running at initial intensity of 100 cycles per minute with an increment of four cycle per minute (E1 – E12). HR and RPE measures were registered at each stage. Reproducibility was analyzed by Pearson linear coefficient (r) and intraclass correlation (ICC), and Wilcoxon test. No significant differences were found among evaluators’ measures for the resting (p > .05), basal (p > .05) and recovery (p > .05) heart rate. Significant differences (p .60, ICC95% > .60). The results show good intra-assessment reproducibility for HR and RPE at different cadences, indicating that the protocol has professional application.
Young Children's Ideas about the Earth in Space

Abstract Children's ideas about the Earth in space, at least in terms of its shape and gravitational attraction, have been of interest to science education researchers and cognitive psychologists for some time. Focusing on shape and gravity alone, however, may have resulted in an underestimation of children's other abilities and learning potential in this field. Details from a recent survey of children's ideas arc presented which suggest that this might be the case. The findings highlight a need for care at a time when classroom expectations are increasingly driven and constrained by ‘educational guidelines’ and ‘science curricula’ which remain to be fully informed.
The emergence of creole subject–verb agreement and the licensing of null subjects

A corpus of conversational Bislama (a Melanesian creole spoken in Vanuatu, related to Tok Pisin and Solomon Islands Pijin) suggests that during the 20th century the creole has developed a set of regular inflectional morphemes on the verb that agree in person and number with the subject of the finite clause. It is shown that, where the agreement paradigm is referentially richest, the language is also beginning to grammaticize a tendency towards phonetically null subjects (pro-drop). Three possible analyses of the Bislama verb phrase are evaluated; consistent support for only one is found in the spoken Bislama corpus. The resulting paradigm of subject–verb agreement (i, oli, and Ø) is analyzed in terms of the historical development of Bislama. It is argued that the synchronic agreement marking reflects properties derived from (i) the lexifier (English), (ii) the substrate languages, and (iii) universal grammar. No one component fully accounts for the patterns of agreement marking observed. Instead, a synthesis of all three is required, as previously observed by, for example, G. Sankoff (1984) and Mufwene (1996). Substrate languages provide a model for subject agreement prefixing on the verb; the person features associated with the lexifier ‘he’ continue to be reflected in the distribution of Bislama i; and phonetically null subjects are emerging as the norm where the agreement paradigm best serves to identify the subject referent. This is consonant with generative accounts of null subject systems. Parallels with other languages (e.g., Italian, Franco-Provençal, Hebrew, Finnish) are examined.
Building underwater ad-hoc networks and sensor networks for large scale real-time aquatic applications

Large-scale underwater ad-hoc networks (UANET) and underwater sensor networks (UWSN) are novel networking paradigms to explore the uninhabited oceans. However, the characteristics of these new networks, such as huge propagation delay, floating node mobility, and limited acoustic link capacity, are significantly different from ground-based mobile ad-hoc networks (MANET) and wireless sensor networks (WSN). In this paper we adopt a top-down approach to explore the new research subject. We at first show a new practical application scenario that cannot be addressed by existing technology and hence demands the advent of the UANET and UWSN. Then along the layered protocol stack, we go down from the top application layer to the bottom physical layer. At each layer we show a set of new design challenges. We conclude that UANET and UWSN are challenges that must be answered by inter-disciplinary efforts of acoustic communication, signal processing and mobile acoustic network protocol design
Lung Nodule Classification Using Deep Features in CT Images

Early detection of lung cancer can help in a sharp decrease in the lung cancer mortality rate, which accounts for more than 17% percent of the total cancer related deaths. A large number of cases are encountered by radiologists on a daily basis for initial diagnosis. Computer-aided diagnosis (CAD) systems can assist radiologists by offering a "second opinion" and making the whole process faster. We propose a CAD system which uses deep features extracted from an auto encoder to classify lung nodules as either malignant or benign. We use 4303 instances containing 4323 nodules from the National Cancer Institute (NCI) Lung Image Database Consortium (LIDC) dataset to obtain an overall accuracy of 75.01% with a sensitivity of 83.35% and false positive of 0.39/patient over a 10 fold cross validation.
Integration of Vibrotactile Signals for Whisker-Related Perception in Rats Is Governed by Short Time Constants: Comparison of Neurometric and Psychometric Detection Performance

Rats explore environments by sweeping their whiskers across objects and surfaces. Both sensor movement and repetitive sweeping typical for this behavior require that vibrotactile signals are integrated over time. While temporal integration properties of neurons along the whisker somatosensory pathway have been studied extensively, the consequences for behavior are unknown. Here, we investigate the ability of head-fixed rats to integrate information over time for the detection of near-threshold pulsatile deflection sequences applied to a single whisker. Psychometric detection performance was assessed with whisker stimuli composed of different numbers of pulses (1-31) delivered at varying frequencies (10, 20, 100 Hz). Detection performance indeed improved with increasing number and frequency of pulses, albeit this improvement was much lower than predicted by probabilistic combination, suggesting highly sublinear integration of pulses. This behavioral observation was reflected in the firing properties of concomitantly recorded barrel cortex neurons, which showed substantial response adaptation to repetitive whisker deflection. To estimate the integration time with which barrel cortex neuronal activity must be read out to match behavior, we constructed a model monitoring spiking activity of simulated neuronal pools, where spike trains were channeled through a leaky integrator with exponential decay. Detection was accomplished by simple threshold crossings. This simple model gave an excellent match of neurometric and psychometric data at surprisingly small time constants τ of 5–8 ms, thus limiting integration largely to <25 ms. This result carries important implications regarding sensory processing for whisker-mediated perception.
“Intensity-Response” Effects of Electroacupuncture on Gastric Motility and Its Underlying Peripheral Neural Mechanism

The aim of this study was to explore the “intensity-response” relationship between EAS and the effect of gastric motility of rats and its underlying peripheral neural mechanism by employing ASIC3 knockout (ASIC3−/−), TRPV1 knockout (TRPV1−/−), and C57BL/6 mice. For adult male Sprague-Dawley (n = 18) rats, the intensities of EAS were 0.5, 1, 3, 5, 7, and 9 mA, respectively. For mice (n = 8 in each group), only 1 mA was used, by which C fiber of the mice can be activated. Gastric antrum motility was measured by intrapyloric balloon. Gastric motility was facilitated by EAS at ST36 and inhibited by EAS at CV12. The half maximal facilitation intensity of EAS at ST36 was 2.1–2.3 mA, and the half maximal inhibitory intensity of EAS at CV12 was 2.8 mA. In comparison with C57BL/6 mice, the facilitatory effect of ST36 and inhibitive effect of CV12 in ASIC3−/− mice decreased, but the difference was not statistically significant (P > 0.05). However, these effects in TRPV1−/− mice decreased significantly (P < 0.001). The results indicated that there existed an “intensity-response” relationship between EAS and the effect of gastric motility. TRPV1 receptor was involved in the regulation of gastric motility of EAS.
Caffeine‐mediated BDNF release regulates long‐term synaptic plasticity through activation of IRS2 signaling

Caffeine has cognitive‐enhancing properties with effects on learning and memory, concentration, arousal and mood. These effects imply changes at circuital and synaptic level, but the mechanism by which caffeine modifies synaptic plasticity remains elusive. Here we report that caffeine, at concentrations representing moderate to high levels of consumption in humans, induces an NMDA receptor‐independent form of LTP (CAFLTP) in the CA1 region of the hippocampus by promoting calcium‐dependent secretion of BDNF, which subsequently activates TrkB‐mediated signaling required for the expression of CAFLTP. Our data include the novel observation that insulin receptor substrate 2 (IRS2) is phosphorylated during induction of CAFLTP, a process that requires cytosolic free Ca2+. Consistent with the involvement of IRS2 signals in caffeine‐mediated synaptic plasticity, phosphorylation of Akt (Ser473) in response to LTP induction is defective in Irs2−/− mice, demonstrating that these plasticity changes are associated with downstream targets of the phosphoinositide 3‐kinase (PI3K) pathway. These findings indicate that TrkB‐IRS2 signals are essential for activation of PI3K during the induction of LTP by caffeine.
Responses to Manipulability of a Play Object

Preschool children's (40 boys, 40 girls) responses to varied manipulability of a play object were tested within a free play environment. A length of simple climbing rope was presented to Ss when attached (low manipulability) and unattached (high manipulability). A clear preference was found for rope with high manipulability.
Do Restrictions on Home Equity Extraction Contribute to Lower Mortgage Defaults? Evidence from a Policy Discontinuity at the Texas Border

Texas is the only US state that limits home equity borrowing to 80 percent of home value. This paper exploits this policy discontinuity around the Texas’ interstate borders and uses a multidimensional regression discontinuity design framework to find that limits on home equity borrowing in Texas lowered the likelihood of mortgage default by about 1 percentage point for all mortgages and 2-4 percentage points for nonprime mortgages. Estimated nonprime mortgage default hazards within 25 to 100 miles on either side of the Texas’ border are about 15 percent smaller as one crosses into Texas.
Graft-versus-Host Disease Is Enhanced by Selective CD73 Blockade in Mice

CD73 functions as an ecto-5′-nucleotidase to produce extracellular adenosine that has anti-inflammatory and immunosuppressive activity. We here demonstrate that CD73 helps control graft-versus-host disease (GVHD) in mouse models. Survival of wild-type (WT) recipients of either allogeneic donor naïve CD73 knock-out (KO) or WT T cells was similar suggesting that donor naïve T cell CD73 did not contribute to GVHD. By contrast, donor CD73 KO CD4+CD25+ regulatory T cells (Treg) had significantly impaired ability to mitigate GVHD mortality compared to WT Treg, suggesting that CD73 on Treg is critical for GVHD protection. However, compared to donor CD73, recipient CD73 is more effective in limiting GVHD. Pharmacological blockade of A2A receptor exacerbated GVHD in WT recipients, but not in CD73 KO recipients, suggesting that A2 receptor signaling is primarily implicated in CD73-mediated GVHD protection. Moreover, pharmacological blockade of CD73 enzymatic activity induced stronger alloreactive T cell activity, worsened GVHD and enhanced the graft-versus-leukemia (GVL) effect. These findings suggest that both donor and recipient CD73 protects against GVHD but also limits GVL effects. Thus, either enhancing or blocking CD73 activity has great potential clinical application in allogeneic bone marrow transplants.
The Dutch Entrustment Act (TBS): Its Principles and Innovations

Terbeschikkingstelling (TBS) is a provision in the Dutch criminal code that allows for a period of treatment following a prison sentence for mentally disordered offenders. This article describes the legal criteria as well as the actual treatment environment of the TBS. Discussion focuses on the selection of patients and the indications for treatment, quality improvement in treatment programs and their evaluation, and the exchange of knowledge about the TBS approach and its effectiveness.
Environmental Education for Behaviour Change: Which actions should be targeted?

One aim of environmental education is to enable people to make informed decisions about their environmental behaviour; this is particularly significant with environmental problems that are believed to be both major and imminent, such as climate change resulting from global warming. Previous research suggests no strong link between a person's general environmental attitudes and knowledge, and his or her willingness to undertake pro-environmental actions, so this study focuses on some specific issues. Using survey methods to produce quantitative data about students' beliefs concerning the usefulness of specific actions and their willingness to adopt them, novel indices have been constructed that indicate the potential of education to increase students' willingness to undertake those actions. The findings imply that altering a student's belief about certain issues will have little effect on their willingness to act. This can be because most students, even those with only a weak belief in the efficacy, are prepared to take action anyway. Conversely, it can be because a majority, including those convinced about the efficacy, are not prepared to take action. Education about such actions, where there is only a weak link between believed effectiveness and willingness to act, may be ineffective in terms of changing practice, because other factors such as social norms and situational influences dominate. For such actions other strategies may be required. For another set of actions, however, the benefits of education in changing practice seemed more positive; increasing recycling, reducing the use of artificial fertilisers and planting more trees are examples.