Miracle-dz/UniFAR-FTUs huggingface dataset:
Massive MIMO-Enabled Full-Duplex Cellular Networks

We provide a theoretical framework for the study of massive multiple-input multiple-output (MIMO)-enabled full-duplex (FD) cellular networks in which the residual self-interference (SI) channels follow the Rician distribution and other channels are Rayleigh distributed. In order to facilitate bi-directional wireless functionality, we adopt: 1) in the downlink (DL), a linear zero-forcing (ZF) with SI-nulling precoding scheme at the FD base stations and 2) in the uplink (UL), an SI-aware fractional power control mechanism at the FD mobile terminals. Linear ZF receivers are further utilized for signal detection in the UL. The results indicate that the UL rate bottleneck in the FD baseline single-input single-output system can be overcome via exploiting massive MIMO. On the other hand, the findings may be viewed as a reality-check, since we show that, under state-of-the-art system parameters, the spectral efficiency gain of FD massive MIMO over its half-duplex counterpart is largely limited by the cross-mode interference between the DL and the UL. In point of fact, the anticipated twofold increase in SE is shown to be only achievable when the number of antennas tends to be infinitely large.
Abnormal Elongations of HOX Gene Clusters May Cause Cancer

Hox gene activation is crucial for normal development of most organisms. Because of its importance, in both development and disease, it is intensively studied. Up to now, molecular methods have been almost exclusively used in order to explore the underlying mechanisms in normal embryonic growth (Tarchini and Duboule, 2006; Tschopp et al., 2009). The clustering of Hox genes is of particular interest in the case of the vertebrates (Duboule, 2007). Using classical genetic methods, Lewis discovered the fundamental property of Hox gene collinearity (Lewis, 1978). According to this collinearity, the ordered Hox1, Hox2, Hox3, etc., genes along the telomeric (3) to the centromeric (5) direction on the chromosome are activated in the same order in the ontogenetic units along the Anterior (head)—Posterior (tail) A/P axis of the embryo. The main feature of Hox gene collinearity is its multiscalar nature: the compact size of an inactivated Hox cluster is about 150 nm whereas the linear size of an early (mouse) embryo is about 1mm. The two sizes differ bymore than 4 orders of magnitude therefore themolecular mechanisms alone are not adequate to describe all Hox cluster collinearity data. Physical laws are more suitable to interrelate phenomena and entities extending over so different spatial scales, as for example the electrons and the nucleus of an atom. In the simplest case of the hydrogen atom, the electron is located in an “electronic cloud” around the nucleus (a proton). The size of the “electron cloud” is more than 4 orders of magnitude greater compared to the size of the atomic nucleus. The Coulomb force keeps the electron on track around the nucleus while the long-range structure of this force covers the space in between. The aforementioned multiscalar physical example motivated the formulation of an alternative model, the biophysical model (BM), to explain the collinear transcription in the Hox gene clusters (Papageorgiou, 2001, 2006). A simple heuristic pulling force F was introduced depending on two factors N and P giving rise to the following equation:
Sexual Conflict and Sexually Antagonistic Coevolution in an Annual Plant

Background Sexual conflict theory predicts sexually antagonistic coevolution of reproductive traits driven by conflicting evolutionary interests of two reproducing individuals. Most studies of the evolutionary consequences of sexual conflicts have, however, to date collectively investigated only a few species. In this study we used the annual herb Collinsia heterophylla to experimentally test the existence and evolutionary consequences of a potential sexual conflict over onset of stigma receptivity. Methodology/Principal Findings We conducted crosses within and between four greenhouse-grown populations originating from two regions. Our experimental setup allowed us to investigate male-female interactions at three levels of geographic distances between interacting individuals. Both recipient and pollen donor identity affected onset of stigma receptivity within populations, confirming previous results that some pollen donors can induce stigma receptivity. We also found that donors were generally better at inducing stigma receptivity following pollen deposition on stigmas of recipients from another population than their own, especially within a region. On the other hand, we found that donors did worse at inducing stigma receptivity in crosses between regions. Interestingly, recipient costs in terms of lowered seed number after early fertilisation followed the same pattern: the cost was apparent only if the pollen donor belonged to the same region as the recipient. Conclusion/Significance Our results indicate that recipients are released from the cost of interacting with local pollen donors when crossed with donors from a more distant location, a pattern consistent with a history of sexually antagonistic coevolution within populations. Accordingly, sexual conflicts may have important evolutionary consequences also in plants.
Associations Between Adolescents’ Perceptions of Alcohol Norms and Alcohol Behaviors: Incorporating Within-school Variability

ABSTRACT Background: Social norm interventions have been implemented in schools to address concerns of alcohol use among high school students; however, research in this area has not incorporated measures of variability that may better reflect the complexity of social influences. Purpose: To examine the association between perceived alcohol norms, the student- and school-level variability of those norms, and alcohol use behaviors among high school students. Methods: A sample of 25 824 students from 58 high schools completed an online self-report survey. Hierarchical linear regression models were fit to examine the relationships between student- and school-level alcohol norm predictors, within-school variability, and current alcohol use and binge drinking. Results: Individual- and school-level norms were predictive of both current alcohol use and binge drinking. Whereas measures of norm diversity at the school level were not predictive of alcohol use behaviors, individual norm proximity was predictive of both current alcohol use and binge drinking. Discussion: The study findings were consistent with prior research and support assertions that variability measures should be incorporated into social norms research approaches. Translation to Health Education Practice: The findings support the incorporation of student-level variability measures, which could assist in identifying students who are susceptible to peer influence.
Current‐fed isolated PFC pre‐regulator for multiple LED lamps with extended lifetime

To emit high‐quality LED light, one or a bin of LED lamp(s) is normally driven by a PWM‐controlled constant current source to minimize device variation and achieve accurate brightness control. Powered from offline AC mains, the front‐end power converters should provide a relatively low DC voltage bus for the inputs of post‐end LED current regulators. To match the long lifetime of LEDs, the whole LED driver (ballast) should work as durably as the LEDs. However, the lifetime of the driver is usually limited by the high‐voltage electrolytic charge storage capacitors used in conventional PFC pre‐regulators. In this paper, our previously proposed resonant current‐fed isolated PFC pre‐regulator is extended to operate in discontinuous conduction mode (DCM). It allows the use of the low‐voltage storage capacitors on the transformer secondary, and therefore extends the overall lifetime of the LED lighting system. A detailed procedure for finding the expected lifetime of the low‐voltage electrolytic capacitor is given. As before, the high‐voltage stress on the main switches, which is typical in current‐fed isolated converters, is reduced substantially by taking advantage of the transformer leakage inductance necessary for resonance. Additionally, high efficiency is ensured by the use of dual non‐cascading structures. Steady‐state state‐space averaging analysis is performed for designing the converter in DCM operation. A prototype converter is built to verify performance of the proposed PFC LED pre‐regulator. Copyright © 2011 John Wiley & Sons, Ltd.
Epidemiology of Diarrheal Illness in Pediatric Oncology Patients

Background Diarrhea is common in children with cancer, but this has not been systematically studied to date. Methods Remnant stool samples collected between January 2010 and June 2011 from pediatric oncology patients with diarrhea were tested for bacterial, viral, and parasitic enteropathogens using a combination of standard-of-care (SOC) diagnostic tests, including broad-range, real-time polymerase chain reaction (PCR) assays for adenoviruses, astroviruses, and sapoviruses and 2 commercially available multiplexed PCR assays. Corresponding demographic and clinical data were abstracted from patients' medical records. Results One hundred fourteen episodes of diarrhea in 93 patients (median age, 3.7 years; range, 0.2-18.8) were included in the study. No patients died, but morbidity was significant. A total of 158 potential pathogens were detected in 114 diarrhea episodes, with >1 organism in one third of these; the most common were Clostridium difficile, noroviruses, adenoviruses, and astroviruses. Clostridium difficile, in combination with norovirus or adenovirus, was most common when >1 pathogen was detected. When both studies were obtained, SOC and broadly multiplexed PCR tests were concordant in 64 episodes (56%). Forty-five pathogens (28%) were identified retrospectively by broadly multiplexed PCR assays only. A total of 19 (13%) were detected by SOC real-time PCR assays but not by either commercially available multiplexed PCR assay. Conclusions Most pediatric oncology patients in this study had 1 or more potential infectious causes for their diarrhea. Additional studies are warranted to understand the natural history of gastroenteritis in this patient population. Although broadly multiplexed PCR assays offer some advantages over conventional testing, there may be disadvantages to their use for the diagnosis of infectious gastroenteritis that are unique to pediatric oncology patients.
A Demonstration of the Uncertainty in Predicting the Estrogenic Activity of Individual Chemicals and Mixtures From an In Vitro Estrogen Receptor Transcriptional Activation Assay (T47D-KBluc) to the In Vivo Uterotrophic Assay Using Oral Exposure.

In vitro estrogen receptor assays are valuable tools for identifying environmental samples and chemicals that display estrogenic activity. However, in vitro potency cannot necessarily be extrapolated to estimates of in vivo potency because in vitro assays are currently unable to fully account for absorption, distribution, metabolism, and excretion. To explore this issue, we calculated relative potency factors (RPF), using 17α-ethinyl estradiol (EE2) as the reference compound, for several chemicals and mixtures in the T47D-KBluc estrogen receptor transactivation assay. In vitro RPFs were used to predict rat oral uterotrophic assay responses for these chemicals and mixtures. EE2, 17β-estradiol (E2), benzyl-butyl phthalate (BBP), bisphenol-A (BPA), bisphenol-AF (BPAF), bisphenol-C (BPC), bisphenol-S (BPS), and methoxychlor (MET) were tested individually, while BPS + MET, BPAF + MET, and BPAF + BPC + BPS + EE2 + MET were tested as equipotent mixtures. In vivo ED50 values for BPA, BPAF, and BPC were accurately predicted using in vitro data; however, E2 was less potent than predicted, BBP was a false positive, and BPS and MET were 76.6 and 368.3-fold more active in vivo than predicted from the in vitro potency, respectively. Further, mixture ED50 values were more accurately predicted by the dose addition model using individual chemical in vivo uterotrophic data (0.7-1.5-fold difference from observed) than in vitro data (1.4-86.8-fold). Overall, these data illustrate the potential for both underestimating and overestimating in vivo potency from predictions made with in vitro data for compounds that undergo substantial disposition following oral administration. Accounting for aspects of toxicokinetics, notably metabolism, in in vitro models will be necessary for accurate in vitro-to-in vivo extrapolations.
Investigation on Reference Frames and Time Systems in Multi-GNSS

Receivers able to track satellites belonging to different GNSSs (Global Navigation Satellite Systems) are available on the market. To compute coordinates and velocities it is necessary to identify all the elements that contribute to interoperability of the different GNSSs. For example the timescales kept by different GNSSs have to be aligned. Receiver-specific biases, or firmware-dependent biases, need to be calibrated. The reference frame used in the representation of the orbits must be unique. In this paper we address the interoperability issues from the standpoint of a Single Point Positioning (SPP) user, i.e., using pseudoranges and broadcast ephemeris. The biases between GNSSs timescales and receiver-dependent biases are analyzed for a set of 31 MGEX (Multi-GNSS Experiment) stations over a time span of more than three years. Time series of biases between timescales of GPS (Global Positioning System), GLONASS (Global Navigation Satellite System), Galileo, BeiDou, QZSS (Quasi-Zenith Satellite System), SBAS (Satellite Based Augmentation System) and NAVIC (Navigation with Indian Constellation) are investigated, in addition to the identification of events like discontinuity of receiver-dependent biases due to firmware updating. The GPS broadcast reference frame is shown to be aligned to the one (IGS14) realized by the precise ephemeris of CODE (Center for Orbit Determination in Europe) to within 0.1 m and 2 milliarcsec, with values dependent on whether IIR-A, IIR-B/M or IIF satellite blocks are considered. Larger offsets are observed for GLONASS, up to 1 m for GLONASS K satellites. For Galileo the alignment of the broadcast orbit to IGS14/CODE is again at the 0.1 m and several milliarcsec level, with the FOC (Full Operational Capability) satellites slightly better than IOV (In Orbit Validation). For BeiDou an alignment of the broadcast frame to IGS14/CODE comparable to GLONASS is observed, regardless of whether IGSO (Inclined Geosynchronous Orbit) or MEO (Medium Earth Orbit) satellites are considered. For all satellites, position differences according to the broadcast ephemeris relative to IGS14/CODE orbits are projected to the radial, along-track and crosstrack triad, with the largest periodic differences affecting mostly the along track component. Sudden discontinuities at the level of up to 1 m and 2–3 ns are observed for the along-track component and the satellite clock, respectively. The time scales of GLONASS, Galileo, QZSS, SBAS and NAVIC are very closely aligned to GPS, with constant offsets depending on receiver type. The offset of the BeiDou time scale to GPS has an oscillatory pattern with peak-to-peak values up to 100 ns. To characterize receiver-dependent biases the average of six Septentrio receivers is taken as reference, and relative offsets of the other receiver types are investigated. These receiver-dependent biases may depend on the individual station, or for the same station on the update of the firmware. A detailed calibration history is presented for each multiGNSS station studied.
B-Lymphocyte Depletion With Rituximab and β-Cell Function: Two-Year Results

OBJECTIVE We previously reported that selective depletion of B-lymphocytes with rituximab, an anti-CD20 monoclonal antibody, slowed decline of β-cell function in recent-onset type 1 diabetes mellitus (T1DM) at 1 year. Subjects were followed further to determine whether there was persistence of effect. RESEARCH DESIGN AND METHODS Eighty-seven subjects (aged 8–40 years) were randomly assigned to, and 81 received, infusions of rituximab or placebo on days 1, 8, 15, and 22. The primary outcome—baseline-adjusted mean 2-h area under the curve (AUC) serum C-peptide during a mixed-meal tolerance test (MMTT) at 1 year—showed higher C-peptide AUC with rituximab versus placebo. Subjects were further followed with additional MMTTs every 6 months. RESULTS The rate of decline of C-peptide was parallel between groups but shifted by 8.2 months in rituximab-treated subjects. Over 30 months, AUC, insulin dose, and HbA1c were similar for rituximab and placebo. However, in evaluating change in C-peptide over the entire follow-up period, the rituximab group means were significantly larger as compared within assessment times with the placebo group means using a global test (P = 0.03). Odds ratio for loss of C-peptide to <0.2 nmol/L following rituximab was 0.565 (P = 0.064). B-lymphocytes recovered to baseline values by 18 months. Serum IgG levels were maintained in the normal range but IgM levels were depressed. CONCLUSIONS Like several other immunotherapeutic approaches tested, in recent-onset T1DM, rituximab delays the fall in C-peptide but does not appear to fundamentally alter the underlying pathophysiology of the disease.
Cardiac arrhythmias in patients with Danon disease

Aims Different cardiac arrhythmias have been suggested to be associated with Danon disease, e.g. Wolff-Parkinson-White syndrome. However, a systematic electrophysiological investigation of patients with Danon disease is lacking thus far. Methods and results Seven patients with Danon disease (4 males, 35.8 ± 10.8 years; 3 females, 51.3 ± 19.9 years) from 3 different families were studied. In all patients, the presence of Danon disease was confirmed by western blot of biopsy material or genetic testing. The patients were characterized by 12-lead electrocardiogram (ECG), Holter ECG, echocardiography, and serial implantable cardioverter defibrillator (ICD) interrogations (in ICD recipients). All male patients underwent electrophysiological investigation (EP study). Asymptomatic ventricular tachyarrhythmias were documented in six of the seven patients. Moreover, 5 of the 7 patients suffered from atrial fibrillation (AF), with 1 of them experiencing thromboembolic stroke at the age of 30 years. In male patients, the initial QRS complex was characterized by a slurring upstroke and shortened PQ interval mimicking ventricular pre-excitation. One male patient showed initial QRS complex slurring with prolonged PR interval. However, the presence of an accessory pathway was excluded by an EP study in all patients. In female patients, initial QRS complex slurring was significantly less distinct. In four patients, ICD implantation was performed for primary prevention of sudden cardiac death. However, sustained ventricular arrhythmias were not documented in any of the patients. Conclusions The present study indicates that the distinct surface ECG pattern in Danon disease is not associated with ventricular pre-excitation. Atrial fibrillation is frequently observed in these patients and may be associated with thromboembolic events in the young, while sustained ventricular arrhythmias occur less frequently than previously reported.
Use of Psychoactive Medication in Short- and Long-term Abstainers from Alcohol

Aim To document the use of prescribed psychoactive medicines in France in patients recovering from alcohol use disorders (AUDs). Method Survey among short- and long-term abstainers attending groups of French self-help associations for AUDs, recording socio-demographic profile, duration of abstinence, prescription of psychoactive medication and attitudes towards that, and whether or not in medical or psychological follow-up for AUD. Result Five hundred seventy-five abstainers participated. More than a half had stopped drinking for at least 5 years. About 25% of the very long-term abstainers were still in follow-up. Benzodiazepines, then antidepressants, were the most frequently used medication. Prescriptions of medication decreased with length of abstinence; was always higher in women than in men and in those with a medical follow-up. About 45% claimed that they were 'dependent' on their pills. Ten years after having stopping drinking, 19 and 42.1% of men and women, respectively, were still under medication. Cluster analysis of self-opinion on medication showed that in ~30% of the subjects medication seemed to be prescribed for precautionary reasons. Conclusion Psychoactive medication in France is frequently prescribed for years following alcohol withdrawal. While it is possible that this is over-prescription, and further work in this regard is needed, changes in an on-going treatment for a given patient would need to be cautious. Short summary Psychoactive medication in alcohol use disorders often prescribed for long-term abstainers in France. Benzodiazepines and antidepressants are the most frequently prescribed drugs. Prescription is more frequent in women and in those subjects having medical follow-up for their alcohol problem. Over-prescription is discussed.
Transcriptome and metabolome of synthetic Solanum autotetraploids reveal key genomic stress events following polyploidization.

Polyploids are generally classified as autopolyploids, derived from a single species, and allopolyploids, arising from interspecific hybridization. The former represent ideal materials with which to study the consequences of genome doubling and ascertain whether there are molecular and functional rules operating following polyploidization events. To investigate whether the effects of autopolyploidization are common to different species, or if species-specific or stochastic events are prevalent, we performed a comprehensive transcriptomic and metabolomic characterization of diploids and autotetraploids of Solanum commersonii and Solanum bulbocastanum. Autopolyploidization remodelled the transcriptome and the metabolome of both species. In S. commersonii, differentially expressed genes (DEGs) were highly enriched in pericentromeric regions. Most changes were stochastic, suggesting a strong genotypic response. However, a set of robustly regulated transcripts and metabolites was also detected, including purine bases and nucleosides, which are likely to underlie a common response to polyploidization. We hypothesize that autopolyploidization results in nucleotide pool imbalance, which in turn triggers a genomic shock responsible for the stochastic events observed. The more extensive genomic stress and the higher number of stochastic events observed in S. commersonii with respect to S. bulbocastanum could be the result of the higher nucleoside depletion observed in this species.