Miracle-dz/UniFAR-FTUs huggingface dataset:
Reduced expression of intercellular adhesion molecule-1 in ovarian adenocarcinomas

Ovarian adenocarcinomas develop as the result of multiple genetic and epigenetic changes in the precursor ovarian surface epithelial (OSE) cells which result in a malignant phenotype. We investigated changes in gene expression in ovarian adenocarcinoma using a cDNA array containing 588 known human genes. We found that intercellular adhesion molecule-1 (ICAM-1) was expressed at lower levels in the ovarian tumour cell lines OAW42, PEO1 and JAM than in the immortalised human ovarian surface epithelial cell line HOSE 17.1. Further investigation revealed ICAM-1 was expressed in the surface epithelium of normal ovaries and both mRNA and protein expression levels were reduced in the majority of ovarian adenocarcinoma cell lines and primary tumours. ICAM-1 expression was increased in 8/8 cell lines treated with the de novo methyltransferase inhibitor 5-aza-2′-deoxycytidine, indicating that methylation of CpG islands may play a role in the down-regulation of its expression in primary tumours. There was a significant association between patients whose tumours expressed ICAM-1 and survival (P= 0.03), suggesting that expression levels of ICAM-1 may have clinical relevance. © 2001 Cancer Research Campaign http://www.bjcancer. com
Multi-scale interactions between local hydrography, seabed topography, and community assembly on cold-water coral reefs

We investigated how interactions between hydrography, topography and species ecology influence the assembly of species and functional traits across multiple spatial scales of a cold-water coral reef seascape. In a novel approach for these ecosystems, we used a spatially resolved complex three-dimensional flow model of hydrography to help explain assembly patterns. Forward-selection of distance-based Moran's eigenvector mapping (dbMEM) variables identified two submodels of spatial scales at which communities change: broad-scale (across reef) and fine-scale (within reef). Variance partitioning identified bathymetric and hydrographic gradients important in creating broad-scale assembly of species and traits. In contrast, fine-scale assembly was related more to processes that created spatially autocorrelated patches of fauna, such as philopatric recruitment in sessile fauna, and social interactions and food supply in scavenging detritivores and mobile predators. Our study shows how habitat modification of reef connectivity and hydrography by bottom fishing and renewable energy installations could alter the structure and function of an entire cold-water coral reef seascape.
A Comparative Study of the Impact of Emotional, Cultural, and Ethical Intelligence of Managers on Improving Bank Performance

Many factors influence human and social systems’ behaviour.The main aim of the current study was to check the status of intelligence in emotional, cultural, and ethical dimensions. Besides, the study examined the effect of those dimensions of intelligence on improving the performance of public and private banks in Ardabil. The current study was practical in terms of the method; cross-sectional in terms of time; inductive in terms of implementation logic; quantitative in terms of the implementation process; and causal in terms of purpose. The population of the study included the managers of public banks of Melli and Sepah and private banks of Pasargad, Eghtesad-e Novin, and Mehr of Ardabil. A questionnaire was set up by the researcher to evaluate the effects of intelligence in emotional, cultural, and ethical dimensions on the banks’ performance. The Cronbach test was used to test the reliability of the questionnaire. Descriptive statistics such as frequency, medium, and mean were used to describe the demographic of the participants. Inferential statistic tests such as Kolmogorov-Smirnov, regression, and independent t were used to analyse the data. The findings of the study showed that in both public and private banks, intelligence in emotional, cultural, and ethical dimensions had a positive impact on the performance of the banks. The effects of cultural intelligence on the performance of the public banks were more than the private banks. However, the impact of emotional and ethical intelligence on the performance of the private banks was more than the public banks.
ShapeWorld - A new test methodology for multimodal language understanding

We introduce a novel framework for evaluating multimodal deep learning models with respect to their language understanding and generalization abilities. In this approach, artificial data is automatically generated according to the experimenter's specifications. The content of the data, both during training and evaluation, can be controlled in detail, which enables tasks to be created that require true generalization abilities, in particular the combination of previously introduced concepts in novel ways. We demonstrate the potential of our methodology by evaluating various visual question answering models on four different tasks, and show how our framework gives us detailed insights into their capabilities and limitations. By open-sourcing our framework, we hope to stimulate progress in the field of multimodal language understanding.
Superior value creation in sports teams: Resources and managerial experience

Resource-based research sustains that organisations (and thus teams) create value through internally developed and complementary acquired resources, through the management of resources and the development of routines. In this study, we advance the understanding of the impact of resources and capabilities by investigating the role of moderators on the key factors of team performance and address the question of when the whole is more than the sum of its parts. We develop and test hypotheses as to how managerial experience helps to foster the development of internal resources and group routines, to extract more value from bought resources, how internally developed resources reinforce group routines and how financial resources influence group routines, the acquisition of resources and the development of internal resources. Data consisted of 270 observations from European professional football leagues over a five-year period. The results confirm that the edifice of competitive advantage is based on a complex resource bundle based on non-obvious interactions between its elements. The complex inter-linkages, reinforcing effects and trade-offs between resources require non-obvious decisions regarding their employment and are best understood by experienced managers.
A cobweb model of financial stability in New Zealand

Financial turbulence over the past two years has generated increased interest in the analysis of financial stability. However, such analysis often suffers from conceptual difficulties and a lack of measurability. This paper develops a ‘cobweb model’ for analysing financial stability in New Zealand. A key objective of this cobweb model is to depict the Reserve Bank of New Zealand’s assessment of financial stability in a single diagram that will enable better communication of the main risks facing New Zealand’s financial system. The results of this model are displayed using a cobweb-style diagram, with five dimensions constructed using a wide range of quantitative indicators, supplemented by expert judgement where necessary. It is anticipated that this cobweb diagram will become the focal point of the Reserve Bank’s Financial Stability Report.
Measuring the Reaction of Monetary Policy to the Stock Market

Movements in the stock market can have a significant impact on the macroeconomy and are therefore likely to be an important factor in the determination of monetary policy. However, little is known about the magnitude of the Federal Reserve's reaction to the stock market. One reason is that it is difficult to estimate the policy reaction because of the simultaneous response of equity prices to interest rate changes. This paper uses an identification technique based on the heteroskedasticity of stock market returns to identify the reaction of monetary policy to the stock market. The results indicate that monetary policy reacts significantly to stock market movements, with a 5% rise (fall) in the S&P 500 index increasing the likelihood of a 25 basis point tightening (easing) by about a half. This reaction is roughly of the magnitude that would be expected from estimates of the impact of stock market movements on aggregate demand. Thus, it appears that the Federal Reserve systematically responds to stock price movements only to the extent warranted by their impact on the macroeconomy.
Substance Use and Mental Health Among Military Spouses and Partners

Abstract Research on the behavioral health of military spouses/partners is essential, yet lacking. Data on 344 civilian spouses were drawn from a study of U.S. Army Reserve/National Guard soldier couples. This project characterizes civilian spouses’ behavioral health symptoms. Regression analyses assessed the relationship between substance use and mental health symptoms. Overall, findings indicate civilian spouses had behavioral health impairments. Mental health, alcohol use, and tobacco use did not differ by soldiers’ deployment history; illicit drug use and nonmedical use of prescription drugs did at trend level. Support initiatives focusing on all military spouses, not just those of deployed soldiers, are needed.
Stability Analysis of Quantum-Dot Spin-VCSELs

Spin-polarized vertical-cavity surface-emitting lasers (spin-VCSELs) and vertical external-cavity surface-emitting lasers (spin-VECSELs) are of interest since their output polarization can be manipulated by spin-selective pumping, either optical or electrical. These devices, using quantum dot (QD) material for the active region, have shown instability (periodic oscillations) and polarization switching in previous theoretical simulations based on a rate equation model. It has been recognized that the polarization switching occurs between two possible sets of solutions, termed here in-phase and out-of-phase. The present contribution seeks to give enhanced understanding of these behaviors by applying a stability analysis to the system of equations used for such simulations. The results indicate that the choice of in-phase and out-of-phase solutions that appear in a time-dependent simulation is determined by the condition that the corresponding steady-state solutions are stable against small perturbations. The stability analysis is shown to be a valuable theoretical tool for future study of spin-V(E)SELs in the context of understanding and guiding future experimental research.
Community-acquired pneumonia (CAP) hospitalizations and deaths: is there a role for quality improvement through inter-hospital comparisons?

OBJECTIVE To assess between-hospital variations in standardized in-hospital mortality ratios of community-acquired pneumonia (CAP), and identify possible leads for quality improvement. DESIGN We used an administrative database to estimate standardized in-hospital mortality ratios for 111 Belgian hospitals, by carrying out a set of hierarchical logistic regression models, intended to disentangle therapeutic attitudes and biases. To facilitate the detection of false-negative/positive results, we added an inconclusive zone to the funnel plots, derived from the results of the study. Data quality was validated by comparison with (i) alternative data from the largest Belgian Sickness Fund, (ii) published German hospital data and (iii) the results of an on-site audit. SETTING All Belgian hospital discharge records from 2004 to 2007. STUDY PARTICIPANTS A total of 111 776 adult patients were admitted for CAP. MAIN OUTCOME MEASURE Risk-adjusted standardized in-hospital mortality ratios. RESULTS Out of the 111 hospitals, we identified five and six outlying hospitals, with standardized mortality ratios of CAP consistently on the extremes of the distribution, as providing possibly better or worse care, respectively, and 18 other hospitals as having possible quality weaknesses/strengths. At the individuals' level of the analysis, adjusted odds ratios showed the paramount importance of old age, comorbidity and mechanical ventilation. The data compared well with the different validation sources. CONCLUSIONS Despite the limitations inherent to administrative data, it seemed possible to establish inter-hospital differences in standardized in-hospital mortality ratios of CAP and to identify leads for quality improvement. Monitoring is needed to assess progress in quality.
Autoimmune Destruction of Islets Transplanted Into RT6-Depleted Diabetes-Resistant BB/Wor Rats

We report a novel animal model of islet transplantation that distinguishes recurrence of autoimmunity from allograft rejection. In this study, diabetes-resistant (DR) BB rats, <1% of which develop spontaneous diabetes, were made hyperglycemic by either a single injection of streptozocin (STZ) or in vivo immune elimination of a regulatory T-lymphocyte subset that expresses the RT6 alloantigen. DR islet grafts were then transplanted into both groups. DR transplants into STZ-induced diabetic DR rats produced long-term normoglycemia. In contrast, DR transplants into DR rats that had been treated with anti-RT6 monoclonal antibody were all destroyed within an average of 4 days. Allogeneic islets transplanted into both STZ-induced and RT6-depleted diabetic DR rats were rejected within a mean of 3 days. We conclude that failure of DR islet grafts in RT6-depleted diabetic DR BB rats represents recurrent autoimmunity.
Analysis of electric signals of rock beams subjected to bending

Experimental laboratory work has been conducted to study electric signals of marble beams that have been subjected to three point bend tests. The specimens have suffered 12 abrupt loading steps up to failure and the corresponding BSC were recorded by means of copper electrodes placed in the lower surface of the sample. Alongside with the application of abrupt loading to the samples, BSC peaks were observed and then the current followed an exponentially decreasing relaxation process. In this paper the BSC peaks, the total charge, as well as the characteristic relaxation time variables are correlated with each other and also with the applied loading. The ultimate purpose is the evaluation of the fatigue of the sample using simple criteria.
Undecidable optimization problems for database logic programs

Datalog is the language of logic programs without function symbols. It is used as a database query language. If it is possible to eliminate recursion from a Datalog program F’, then t’ is said to be bounded. It is shown that the problem of deciding whether a given Datalog program is bounded is undecidable, even for linear programs (i.e., programs in which each rule contains at most one occurrence of a recursive predicate). It is then shown that every semantic property of Datalog programs is undecidable if it is stable, is strongly nontrivial, and contains An earlier version of this work appeared under the same title in the Proceedings of the 2nd IEEE Symposium on Logic i~z Computer Science (Ithaca, N.Y.). IEEE, New York, 1987, pp. 106-115. Most of the research reported here was done while H. Gaifman was visiting the AI Center of SRI International whose support he wishes to acknowledge. He also wishes to thank IBM Watson Research Center and IBM Almaden Research Center for support in the summer of 1989, when the concluding work on this paper was done. The research reported here was done partly while H. Mairson was at the Computer Science Department of Stanford University and was supported by the Office of Naval Research (ONR) contract NOO014-85-C-0731 and partly while he was at the Programming Research Group of Oxford University. The research reported here was done while Y. Sagiv was visiting the Computer Science Department of Stanford University and was supported by a grant of AT & T Foundation, a grant of IBM Corporation and the National Science Foundation (NSF) grant 1ST 84-12791. Authors’ addresses: H. Gaifman and Y. Sagiv, Hebrew University, Jerusalem 91904, Israel; H. Mairson, Department of Computer Science, Brandeis University, Waltham, MA 02254; M. Y. Vardi, IBM Almaden Research Center, K53-802, 650 Harry Road, San Jose, CA 95120-6099. Permission to copy without fee all or part of this material is granted provided that the copies are not made or distributed for direct commercial advantage. the ACM copyright notice and the title of the publication and its date appear, and notice is given that copying is by permission of the Association for Computing Machinery. To copy otherwise, or to republish, requires a fee and/or specific permission. 01993 ACM 0004-5411/93/0700-0683 $01.50 Journal of the Awxmt]on for Computing Machinery, VO1 40, No 3. July 1993. PP 683-713 684 H. GAIFMAN ET AL. boundedness. In particular, the property of being first-order 1s undecidable and (assuming that PTIME 1s different from LOGSPACE and from NC) the same holds for the property of being equivalent to a linear program and for the properties of being in LOGSPACE and of being in NC
Using High-Throughput Sequencing to Leverage Surveillance of Genetic Diversity and Oseltamivir Resistance: A Pilot Study during the 2009 Influenza A(H1N1) Pandemic

Background Influenza viruses display a high mutation rate and complex evolutionary patterns. Next-generation sequencing (NGS) has been widely used for qualitative and semi-quantitative assessment of genetic diversity in complex biological samples. The “deep sequencing” approach, enabled by the enormous throughput of current NGS platforms, allows the identification of rare genetic viral variants in targeted genetic regions, but is usually limited to a small number of samples. Methodology and Principal Findings We designed a proof-of-principle study to test whether redistributing sequencing throughput from a high depth-small sample number towards a low depth-large sample number approach is feasible and contributes to influenza epidemiological surveillance. Using 454-Roche sequencing, we sequenced at a rather low depth, a 307 bp amplicon of the neuraminidase gene of the Influenza A(H1N1) pandemic (A(H1N1)pdm) virus from cDNA amplicons pooled in 48 barcoded libraries obtained from nasal swab samples of infected patients (n = 299) taken from May to November, 2009 pandemic period in Mexico. This approach revealed that during the transition from the first (May-July) to second wave (September-November) of the pandemic, the initial genetic variants were replaced by the N248D mutation in the NA gene, and enabled the establishment of temporal and geographic associations with genetic diversity and the identification of mutations associated with oseltamivir resistance. Conclusions NGS sequencing of a short amplicon from the NA gene at low sequencing depth allowed genetic screening of a large number of samples, providing insights to viral genetic diversity dynamics and the identification of genetic variants associated with oseltamivir resistance. Further research is needed to explain the observed replacement of the genetic variants seen during the second wave. As sequencing throughput rises and library multiplexing and automation improves, we foresee that the approach presented here can be scaled up for global genetic surveillance of influenza and other infectious diseases.
Competency-based curriculum for the expansion of university students’ career spectrums in the dance department

ABSTRACT The purpose of this study was to explore the competency-based curriculum to expand Korean university students’ career spectrums in dance departments. A literature review and a two-time Delphi analysis with seven experts was carried out at the beginning of the study to discover necessary competencies. Thereafter, an Analytical Hierarchy Process (AHP) with another 23 experts was performed to explore the hierarchy of these competencies. Another group of three experts reviewed the dance curricula of six different universities and classified each course in a competency table to understand which competencies were more pursued than others in dance departments. The literature review and Delphi analysis resulted in 10 competencies with 43 subcomponents, with a Content Validity Ratio (CVR) of . 99. Among the competencies, ‘Dance performance’ was ranked highest with a weight of . 187, while ‘Multiculturalism’ was ranked lowest at . 030 in the AHP (.1> consistency index and consistency ratio). In the last phase of the study involving three experts, the competencies pursued in each course were examined, and it was revealed that the number of courses pursuing the competency of ‘Liberal Arts & General Studies’ were overwhelming in the dance curriculum.
Ribosomal DNA Variation in Daphnia pulex

Variation in the ribosomal DNA (rDNA) gene family was surveyed in five cyclically parthenogenetic populations of Daphnia pulex from central Illinois and in obligately parthenogenetic clones from Illinois and Ontario. A total of 37 distinct rDNA repeat types were identified on the basis of restriction-site and repeat-length polymorphism in a sample of 90 isolates. Repeat-type diversity was high within cyclic populations; however, individuals possessed only a small subset of the repeat-type variation present in each population. The distribution of repeat types within and among individuals suggested that new variants spread within rDNA arrays much faster than arrays carrying the variants spread within populations. This observation is contrary to a model developed by Ohta and Dover for strictly sexual organisms. Previous surveys of isozyme and mitochondrial DNA variation in these populations showed that gene flow among them is limited. Hierarchical analysis of rDNA restriction-site variation was consistent with this observation and showed that genetic divergence accumulates between populations for rDNA almost as rapidly as it does for single-copy nuclear genes (isozymes). Analysis of rDNA variation in obligately parthenogenetic clones provided evidence that both intraand interchromosomal exchanges occur between rDNA arrays in the absence of meiosis. Moreover, individuals reproducing by obligate parthenogenesis possessed fewer rDNA repeat types, on average, than did individuals from cyclic populations, suggesting that there is a net loss of rDNA repeat-type variability within obligately clonal lineages over time. Preliminary analyses of two additional species, D. pulicaria and D. obtusa, revealed several restriction-site polymorphisms that were found in more than one of the three species. The existence of such shared polymorphisms advises caution in the use of multigene-family variation to infer phylogenies among species when levels of intraspecific variation have not been assessed.