Miracle-dz/UniFAR-FTUs huggingface dataset:
Asia's Environmental Movements: Comparative Perspectives

The investigation of the rise and fall of Gao Gang suggests broader implications on the nature of elite politics in the Maoist era. The illumination of basic issues in Chinese politics in the context of this case, especially as regards the role of Mao Zedong, is relevant not only to the initial post-1949 period of comparative, but flawed, party unity, but also to the structural fault lines of the political system which were later to contribute so significantly to the Cultural Revolution.
Investigation and comparison of Turkish and American preschool teacher candidates’ attitudes towards inclusion of young children with disabilities

ABSTRACT Inclusion of young children with disabilities into general education classrooms is a common practice that has been implemented for many years in developed countries around the world and many developing countries have been creating and implementing laws and regulations to support inclusive education in early years. Although extant literature includes a commonly agreed definition for inclusion, the implementation of inclusive practices varies across countries. A critical factor for successful implementation of inclusive practices is teachers’ attitudes towards inclusion of children with disabilities. The purpose of this study was to compare Turkish and American pre-service preschool teachers’ attitudes towards inclusion of young children with disabilities and their willingness to work with children with severe behavioural, physical, and cognitive disabilities. A total of 123 pre-service teachers participated in the study. The results showed that pre-service teachers across two countries had similar attitudes towards inclusion and their attitudes were positive. Additionally, both groups of pre-service teachers reported more favourable attitudes towards working with children with severe physical disabilities than those who have severe cognitive and behavioural disabilities. Implications for future research and practices are discussed.
Abdominal Tumor Characterization and Recognition Using Superior-Order Cooccurrence Matrices, Based on Ultrasound Images

The noninvasive diagnosis of the malignant tumors is an important issue in research nowadays. Our purpose is to elaborate computerized, texture-based methods for performing computer-aided characterization and automatic diagnosis of these tumors, using only the information from ultrasound images. In this paper, we considered some of the most frequent abdominal malignant tumors: the hepatocellular carcinoma and the colonic tumors. We compared these structures with the benign tumors and with other visually similar diseases. Besides the textural features that proved in our previous research to be useful in the characterization and recognition of the malignant tumors, we improved our method by using the grey level cooccurrence matrix and the edge orientation cooccurrence matrix of superior order. As resulted from our experiments, the new textural features increased the malignant tumor classification performance, also revealing visual and physical properties of these structures that emphasized the complex, chaotic structure of the corresponding tissue.
Do Streaks Matter in Multiple Choice Tests?

Success in life is determined to a large extent by school performance, which in turn depends heavily on grades obtained in exams. In this study, we investigate a particular type of exam: multiple-choice tests. More concretely, we study if patterns of correct answers in multiple-choice tests affect performance. We design an experiment to study if students who take a multiple-choice test with streaks of identical answers earn fewer points than students taking a test with a variable pattern of answers, and we study several potential mechanisms. We do not find a clear treatment effect, as multiple-choice test points were not significantly lower in a consistent manner in the treatment groups. We observe that in a streak, the likelihood to choose a different and incorrect answer than the previous ones is higher in the treated group. The number of identical previous answers does not seem to explain these choices of incorrect answers.
The Role of District Office Leaders in the Adoption and Implementation of the Common Core State Standards in Elementary Schools

Purpose: This multiple case study investigated district leaders’ orientations and strategies as their elementary schools proceeded with state-mandated implementation of the Common Core State Standards (CCSS). We identified differences between schools achieving above-predicted outcomes on state CCSS assessments (“odds-beaters”) and schools achieving predicted outcomes (“typical performers”). Theory: The implementation of multiple race-to-the-top (RTTT) innovations recommends a theoretical hybrid consisting of policy implementation theory, leadership theory, organizational change theory, and organizational learning theory, especially learning-focused leadership strategies such as bridging, brokering, and buffering strategies for crafting coherence across organizational boundaries. Research Methods: This mixed methods study used statistical regressions for sampling and interviews to collect data. Inductive and deductive methods were used to identify themes that might differentiate the two kinds of sample schools and their district leaders. Findings: District leaders for odds-beating schools anticipated the state’s policy innovations and developed organizational capacity for RTTT innovation implementation. Leaders permitted CCSS adaptations and they employed bridging, brokering, and buffering strategies to craft coherence and facilitate organizational learning and improvement. Conclusions: Odds-beating district leaders played pivotal roles in developing organizational readiness and implementation capacity. Whereas the RTTT agenda in typical districts amounted to a second-order, disruptive change, the odds-beating leaders in this study were instrumental in making this same agenda a first-order change.
Overcoming Perfectionism Roz Shafran, Sarah Egan and Tracey Wade London: Robinson Publishing, 2010. pp. 308, £10.99 (pb). ISBN: 978-1845297428

Chapter 11 helpfully includes a detailed case study to illustrate how to go about identifying the main problems, setting goals, planning interventions and monitoring progress. Helpful case studies are used throughout the book. Part 3 concludes with an excellent Summary and Conclusions chapter, which gives a succinct overview of the content and main learning points of the guide. Overall, this guide is very user-friendly, with an engaging and conversational tone. It is highly interactive, making use of an excellent range of resources throughout, including quizzes, checklists and questionnaires. The author does well to normalize stress and present it as a problem for both the employee and the employer (in terms of loss of productivity). This guide empowers individuals to become their own therapist so as to overcome the very common and serious problem of occupational stress.
Dual effects of 17beta-oestradiol on interleukin 1beta-induced proteoglycan degradation in chondrocytes.

OBJECTIVE To determine whether 17beta-oestradiol (E2) modulates interleukin (IL) 1beta-induced proteoglycan degradation in chondrocytes, and to analyse the part played by metalloproteinases (MMPs) in this process. METHODS Primary cultured rabbit articular chondrocytes were prepared and treated with 10 ng/ml IL1beta combined or not with 0.1-10 nM E2. Neosynthesised proteoglycans (PGs) were evaluated after incorporation of [(35)SO(4)]sulphate and further analysed after chromatography on a Sepharose 2B column. Chondrocyte mRNA levels of aggrecan, MMP-1, -3, -13, and tissue inhibitor of metalloproteinase-1 (TIMP-1) were studied by northern blot. MMP-1 activity was measured by zymography. MMP-1 gene transcription was studied by transient transfection of chondrocytes with an MMP-1-luciferase construct. RESULTS E2 modulated the IL1beta-induced total sulphated PGs in rabbit articular chondrocytes, which decreased as the E2 concentration was increased. At a low concentration (0.1 nmol/l) E2 counteracts the IL1beta-induced decrease in sulphated PG, while at high concentration (10 nmol/l) E2 enhances the IL1beta effects. A biphasic E2 effect was also observed on IL1beta-induced disaggregation of PG, 53-58 kDa gelatinolytic activity, and MMP-1, -3, and -13 mRNA levels. In contrast, E2 did not modify the level of aggrecan mRNA and had no effect on TIMP-1 mRNA expression. Finally, simultaneous addition of IL1beta and E2 (0.1-10 nmol/l) did not modify IL1beta-induced MMP-1-luciferase activity, suggesting that E2 effects probably occur at the post-transcriptional level of MMP gene expression. CONCLUSION Oestrogen concentration may have an inverse effect on IL1beta stimulated proteoglycan degradation and MMP production by chondrocytes.
Incidental Minimal Atypical Lobular Hyperplasia on Core Needle Biopsy: Correlation With Findings on Follow-up Excision

IntroductionAtypical lobular hyperplasia (ALH), often an incidental finding in breast core biopsies, is largely considered to be a risk factor for carcinoma rather than a direct precursor. However, management of ALH is controversial. We review our experience with incidental minimal ALH on core biopsy, and correlate with excision and follow-up results. DesignWe evaluated all cases of ALH on core biopsy from 1999 to 2009 from our institution, focusing on cases with ≤3 foci of ALH (minimal), paired excision, and no other lesion on the core biopsy that by itself would require excision. Cases with discordant clinical/radiologic impressions, suggesting that a suspicious lesion had been missed on biopsy, were excluded. Therefore, the excisions were performed because of the diagnosis of ALH. ResultsOf 56 cases with ALH on biopsy and paired excision, 42 showed minimal ALH. On excision, 26 had residual ALH and 13 were benign. Three cases had other atypical lesions: lobular carcinoma in situ (2 cases) and mild atypical ductal hyperplasia separate from the biopsy site (1 case). On follow-up, only 1 patient developed subsequent ALH in the same breast. No other ipsilateral lesions were later diagnosed (mean follow-up 3.2 y). ConclusionsNo case with ALH on biopsy had a lesion on excision requiring further treatment, suggesting that these patients can be managed more conservatively. Furthermore, no patients were diagnosed with a higher grade lesion in the same breast on follow-up. We propose that, if there is close radiologic correlation and follow-up, minimal incidental ALH on core biopsy (≤3 foci) does not require excision.
Dasatinib inhibits actin fiber reorganization and promotes endothelial cell permeability through RhoA‐ROCK pathway

Treatment with dasatinib, a tyrosine kinase inhibitor, is associated with edema, pleural effusion, and pulmonary edema. We investigated the effect of dasatinib on the barrier function of human microvascular endothelial cells‐1 (HMEC‐1) in vitro and in vivo. The permeability of HMEC‐1 to fluorescein isothiocyante (FITC)‐dextran increased in Transwell chambers within 5 min following the addition of therapeutic concentrations of dasatinib. The change in permeability was associated with increased activation of RhoA GTPase and its effector Rho‐associated coiled‐coil kinase 1(ROCK1). RhoA inhibitor C3 transferase almost completely inhibited dasatinib‐induced increase in permeability. Under similar conditions, imatinib had no effect on permeability or activation of RhoA. Since integrin‐induced cell spreading suppresses RhoA activation, we examined the effect of dasatinib on cell spreading on fibronectin substrate. Dasatinib impaired endothelial cell spreading in a concentration‐dependent manner and induced disorganization of actin fibers. Tyrosine kinases play an essential role in transmitting signals from integrins to RhoA and we examined tyrosine phosphorylation of several cytoskeletal proteins. Dasatinib markedly inhibited tyrosine phosphorylation of p130 Crk‐associated substrate (p130cas), paxillin and vinculin. These results suggest that the inhibition of tyrosine phosphorylation of the focal adhesion plaque components by dasatinib may alter the assembly of actin fibers resulting in the activation of RhoA/ROCK pathway. Consistent with these findings, dasatinib‐induced increase in the permeability was blocked by ROCK inhibitor y27632. In vivo administration of y27632, significantly inhibited the dasatinib‐induced extravasation of Evans blue in mice and dasatinib‐induced increase in microvascular permeability was attenuated in ROCK1‐deficient mice. These findings suggest that ROCK inhibitors could serve as therapeutic modalities to ameliorate the dasatinib‐induced pulmonary changes.
Erbin Inhibits RAF Activation by Disrupting the Sur-8-Ras-Raf Complex*

Erbin is a member of the LAP (leucine-rich repeat (LRR) and PDZ domain) family. It inhibits Ras-mediated activation of ERK in response to growth factors. In this study, we investigated the mechanisms by which Erbin regulates the Ras-Raf-MEK pathway. The N-terminal LRR domain was necessary and sufficient to inhibit neuregulin-activated expression of ϵ416-Luc, a reporter of ERK activation. On the other hand, Erbin had no effect on Ras activation, but it attenuated neuregulin-induced Raf activation, suggesting that Erbin may regulate Raf activation by Ras. Via the LRR domain, Erbin interacts with Sur-8, a scaffold protein necessary for the Ras-Raf complex. Expression of Erbin attenuated the interaction of Sur-8 with active Ras and Raf. Moreover, Erbin-shRNA, which suppressed Erbin expression at mRNA and protein levels, increased the interaction of Sur-8 with Ras and Raf, ERK activation, and neuregulin-induced expression of endogenous acetylcholine receptor ϵ-subunit mRNA. These results demonstrate a regulatory role of Erbin in the Ras-Raf-MEK pathway, suggesting that Erbin may inhibit ERK activation by disrupting the Sur-8-Ras/Raf interaction.
The emerging fi eld of electrosensory and semiochemical shark repellents : Mechanisms of detection , overview of past studies , and future directions

Since the sinking of the USS Indianapolis (CA-35) and associated shark attacks in 1945, the quest to find an effective shark repellent has been endless. Early efforts were focused on finding a shark repellent which would minimize the probability of a shark attack. However, studies illustrate that shark populations are drastically declining which has led to calls for effective management policies and practices to reduce both directed catch and bycatch of various shark species. With increased need for shark conservation, the focus has shifted to protecting sharks from harmful anthropogenic pressures, such as fishing gear and beach nets. Current shark repellent technologies which aim to minimize elasmobranch mortality in fishing gears include: permanent magnets, electropositive metal (EPM) alloys, and semiochemicals. This paper will review present electrosensory and semiochemical shark repellents, the mechanisms of elasmobranch (e.g. shark, skate and ray) detection and repellency, species-specificity in elasmobranch response to the stimuli, and environmental and biological conditions which may influence repellent success. Future research to enhance our knowledge on electrosensory repellents and to improve the success of repellent implementation and application will be discussed. 2012 Elsevier Ltd. All rights reserved.
Rabies Virus Vector Transgene Expression Level and Cytotoxicity Improvement Induced by Deletion of Glycoprotein Gene

The glycoprotein (G) of rabies virus (RV) is required for binding to neuronal receptors and for viral entry. G-deleted RV vector is a powerful tool for investigating the organization and function of the neural circuits. It gives the investigator the ability to genetically target initial infection to particular neurons and to control trans-synaptic propagation. In this study we have quantitatively evaluated the effect of G gene deletion on the cytotoxicity and transgene expression level of the RV vector. We compared the characteristics of the propagation-competent RV vector (rHEP5.0-CVSG-mRFP) and the G-deleted RV vector (rHEP5.0-ΔG-mRFP), both of which are based on the attenuated HEP-Flury strain and express monomeric red fluorescent protein (mRFP) as a transgene. rHEP5.0-ΔG-mRFP showed lower cytotoxicity than rHEP5.0-CVSG-mRFP, and within 16 days of infection we found no change in the basic electrophysiological properties of neurons infected with the rHEP5.0-ΔG-mRFP. The mRFP expression level of rHEP5.0-ΔG-mRFP was much higher than that of rHEP5.0-CVSG-mRFP, and 3 days after infection the retrogradely infected neurons were clearly visualized by the expressed fluorescent protein without any staining. This may be due to the low cytotoxicity and/or the presumed change in the polymerase gene (L) expression level of the G-deleted RV vector. Although the mechanisms remains to be clarified, the results of this study indicate that deletion of the G gene greatly improves the usability of the RV vector for studying the organization and function of the neural circuits by decreasing the cytotoxicity and increasing the transgene expression level.
Herpes simplex virus as a determinant risk factor for coronary artery atherosclerosis and myocardial infarction.

BACKGROUND Viruses have been detected in atherosclerotic and non-atherosclerotic vascular tissues and may be involved in the mechanisms of atherogenesis. In the present study, we investigated the role of herpes simplex virus (HSV) in the early and late stages of coronary artery atherosclerosis. METHODS AND RESULTS HSV prevalence was investigated in coronary artery samples from 42 autopsy cases, in which death was related to myocardial infarction (MI), and 28 young age autopsy cases without heart disease, who had died from fatal injuries (young victim group), using nested polymerase chain reaction (nPCR) and the highly sensitive in situ hybridization with tyramide signal amplification (ISH-TSA). HSV was detected by nPCR in 18 out of 42 (43%) myocardial infarction cases and in 7 out of 28 (25%) young victim group cases, respectively. Using ISH-TSA, HSV DNA was detected in the coronary arteries of the MI group in 16 out of 42 (38%) of the cases; the hybridization signal was localized in the nuclei of endothelial cells, the nuclei of smooth muscle cells, the macrophages around the atheroma, and in the lymphocytes infiltrating the vascular wall. In the young victim group, HSV DNA was detected by ISH-TSA in 7 out of 28 (25%) autopsy cases; the signal was localized in the endothelial and the intimal spindle cells of the coronary arteries. CONCLUSION The findings of this study suggest that HSV seems to play a significant role in the initiation and progression of coronary atherosclerosis, and may open new perspectives in preventing the development of vascular damage via an appropriate antiviral treatment.
Killing niche competitors by remote-control bacteriophage induction

A surprising example of interspecies competition is the production by certain bacteria of hydrogen peroxide at concentrations that are lethal for others. A case in point is the displacement of Staphylococcus aureus by Streptococcus pneumoniae in the nasopharynx, which is of considerable clinical significance. How it is accomplished, however, has been a great mystery, because H2O2 is a very well known disinfectant whose lethality is largely due to the production of hyperoxides through the abiological Fenton reaction. In this report, we have solved the mystery by showing that H2O2 at the concentrations typically produced by pneumococci kills lysogenic but not nonlysogenic staphylococci by inducing the SOS response. The SOS response, a stress response to DNA damage, not only invokes DNA repair mechanisms but also induces resident prophages, and the resulting lysis is responsible for H2O2 lethality. Because the vast majority of S. aureus strains are lysogenic, the production of H2O2 is a very widely effective antistaphylococcal strategy. Pneumococci, however, which are also commonly lysogenic and undergo SOS induction in response to DNA-damaging agents such as mitomycin C, are not SOS-induced on exposure to H2O2. This is apparently because they are resistant to the DNA-damaging effects of the Fenton reaction. The production of an SOS-inducing signal to activate prophages in neighboring organisms is thus a rather unique competitive strategy, which we suggest may be in widespread use for bacterial interference. However, this strategy has as a by-product the release of active phage, which can potentially spread mobile genetic elements carrying virulence genes.
Assessment of metabolites in bioequivalence studies: should bioequivalence criteria be applied on the sum of parent compound and metabolite?

OBJECTIVES The objective of this study was to demonstrate the impact of the sum of parent compound and metabolite in bioequivalence assessment. METHODS Four drugs with active metabolite were selected to assess bioequivalence. Bioequivalence criteria of 80 - 125% were applied to the parent compound, the metabolite, and the sum of parent compound and metabolite. RESULTS The results indicated that the application of 80 - 125% bioequivalence criteria to the sum of parent compound and metabolite might be misleading. CONCLUSION The 90% confidence interval should be applied separately to the parent compound and each metabolite.
Childhood Leukemia Not Linked with ELF Magnetic Fields

The discussion whether extremely low frequency (ELF) magnetic fields (MF) are causally linked with childhood leukemia is ongoing for almost four decades. Results of epidemiologic studies have indicated such an association might exist and led to IARC’s classification of ELF MF as possibly carcinogenic (class 2B). Although in the meanwhile many epidemiologic studies and meta-analyses of selected studies are available, this did not change the situation. By a new approach of pooling all epidemiologic data, this paper shows that it is possible to come to a convincing conclusion which explains controversial results and reports dose-response relationship, and provides answers to striking facts such as that epidemiologic results on childhood leukemia are independent from field source or exposure metric of whatever kind with no specific favorite. The analysis revealed that the assumption of a causal link between ELF MF exposure and childhood leukemia is no longer plausible and hence that ELF MF’s classification as possibly carcinogenic needs revision.
On the Oblivious Transfer Capacity of Noisy Correlations

We deal with the task of obtaining oblivious transfer from noisy resources. We characterize which noisy channels/distributions are useful for obtaining oblivious transfer. We also introduce the problem of computing the oblivious transfer capacity of a noisy resource, which measures the optimal way of implementing oblivious transfer from a noisy channel/ distribution. We show that for honest but curious sender, the oblivious transfer capacity of noisy resources is strictly positive. Several open questions are raised