Miracle-dz/UniFAR-FTUs huggingface dataset:
The sense of flutter-vibration: comparison of the human capacity with response patterns of mechanoreceptive afferents from the monkey hand.

IT WAS OUR PURPOSE in the studies described in the intact, behaving organism are therefore this paper to combine two experimental of the first importance for sensory neurophysdesigns which differ remarkably in method, iology, for they establish: 7) the dynamic and in their historical and conceptual derange required of the input on the afferent side of the system to account for the output-the measured sensory capacities; 2) the information about the stimulus which must be preserved in the initial encoding to account for the over-all information transmitting capacity of the nervous system in a particular sensory sphere; and 3) a basis for determining which of the many codes available to the pulse-operated input sys tern may be of functional significance in the sensory performance measured. It is thought that a continued correlation of the results of these two types of studies will set the limits and establish some of the parameters to be expected of that higher order neural mechanism intervening between initial cortical display and sensory experience, referred to above. mechanisms (30). Electrophysiological studies, particularly with the method of singleunit analysis, can now provide precise measures of the neural encoding in first-order nerve fibers of the parameters of peripheral stimuli, and of the successive relay and transformation of that neural replication from periphery to cerebral cortex. They have so far provided little understanding of those cerebral mechanisms which, operating upon the transformed replication of the peripheral event in the primary receiving areas of the cerebral cortex, are thought to lead to subjective sensory experience and its overt behavioral counterparts. Psychophysical studies, on the other hand, seek to establish Ideally, the two types of observation should be made in the same organism at the same lawful relations between those experiences time. Given the demands of the single-unit and certain physical aspects of the stimuli method when applied in its quantitative which evoke them. The results of these quantiform, and particularly the desired level of tative measures of the sensory performance of control of stimulus parameters, this is not vet possible for somesthesis. For the present Received for publication August 24, 1967. l This study was supported by Public Health &e Ahave made the assumption thai what Service Grants NB-1045 and NB-06828, Air Force monkeys and humans feel with their hands Contract no. 49 (638) 1305. is in principle the same, and that neuro2 Visiting Lecturer in Physiology, 1966, from the physiological observations made in the one School of Physiology, University of New South Wales, New South Wales, Australia. may with some validity be correlated with 3 Foreign Fellow of the Public Health Service, psychophysical measures in the other, given 1965-1966, from the University of Freiburg im Breisa precise identity of experimental design in gau, Germany. the two cases.
Learning By Trading

Using a large sample of individual investor records over a nine-year period, we analyze survival rates, the disposition effect, and trading performance at the individual level to determine whether and how investors learn from their trading experience. We find evidence of two types of learning: some investors become better at trading with experience, while others stop trading after realizing that their ability is poor. A substantial part of overall learning by trading is explained by the second type. By ignoring investor attrition, the existing literature significantly overestimates how quickly investors become better at trading. The Author 2009. Published by Oxford University Press on behalf of The Society for Financial Studies. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org, Oxford University Press.
Cluster Galaxy Evolution from a New Sample of Galaxy Clusters at 0.3 < z < 0.9

We analyze photometry and spectroscopy of a sample of 63 clusters at 0.3 ≤ z ≤ 0.9 drawn from the Las Campanas Distant Cluster Survey to empirically constrain models of cluster galaxy evolution. Specifically, (1) by combining I-band photometry of 44 of our clusters with that of 19 clusters from the literature, we parameterize the redshift dependence of M in the observed frame as M = (-21.74 ± 0.12) - (0.88 ± 0.24)z - 5 log h (rms deviation = 0.34) for 0.3 ≤ z ≤ 0.9 (Ω0 = 0.2, ΩΛ = 0); (2) by combining 30 of our clusters and 14 clusters from the literature with V and I data, we parameterize the redshift dependence of the V-I color of the E/S0 red sequence in the observed frames as V-I = (-0.24 ± 0.28) + (7.42 ± 1.03)z - (4.61 ± 0.91)z2 (rms deviation = 0.16) for 0.3 ≤ z ≤ 0.9; and (3) by combining 13 of our clusters with 15 clusters from the literature with I and K′ data, we parameterize the redshift dependence of the I-K′ color of the E/S0 red sequence in the observed frames as I-K′ = (0.66 ± 0.65) + (9.50 ± 3.72)z - (14.72 ± 7.01)z2 + (8.72 ± 4.29)z3 (rms deviation = 0.18) for 0.3 ≤ z ≤ 0.9. Using the peak surface brightness of the cluster detection, Σ, as a proxy for cluster mass, we find no correlation between Σ and M or the location of the red envelope in V-I. We suggest that these observations can be explained with a model in which luminous early-type galaxies (or more precisely, the progenitors of current-day luminous early-type galaxies) form the bulk of their stellar populations at high redshifts (≳5) and in which many of these galaxies, if not all, accrete mass either in the form of evolved stellar populations or gas that causes only a short-term episode of star formation at lower redshifts (1.5 < z < 2). Our data are too crude to reach conclusions regarding the evolutionary state of any particular cluster or to investigate whether the morphological evolution of galaxies matches the simple scenario that we discuss, but the statistical nature of this study suggests that the observed evolutionary trends are universal in massive clusters.
Genome-Wide Immune Modulation of TLR3-Mediated Inflammation in Intestinal Epithelial Cells Differs between Single and Multi-Strain Probiotic Combination

Genome-wide transcriptional analysis in intestinal epithelial cells (IEC) can aid in elucidating the impact of single versus multi-strain probiotic combinations on immunological and cellular mechanisms of action. In this study we used human expression microarray chips in an in vitro intestinal epithelial cell model to investigate the impact of three probiotic bacteria, Lactobacillus helveticus R0052 (Lh-R0052), Bifidobacterium longum subsp. infantis R0033 (Bl-R0033) and Bifidobacterium bifidum R0071 (Bb-R0071) individually and in combination, and of a surface-layer protein (SLP) purified from Lh-R0052, on HT-29 cells’ transcriptional profile to poly(I:C)-induced inflammation. Hierarchical heat map clustering, Set Distiller and String analyses revealed that the effects of Lh-R0052 and Bb-R0071 diverged from those of Bl-R0033 and Lh-R0052-SLP. It was evident from the global analyses with respect to the immune, cellular and homeostasis related pathways that the co-challenge with probiotic combination (PC) vastly differed in its effect from the single strains and Lh-R0052-SLP treatments. The multi-strain PC resulted in a greater reduction of modulated genes, found through functional connections between immune and cellular pathways. Cytokine and chemokine analyses based on specific outcomes from the TNF-α and NF-κB signaling pathways revealed single, multi-strain and Lh-R0052-SLP specific attenuation of the majority of proteins measured (TNF-α, IL-8, CXCL1, CXCL2 and CXCL10), indicating potentially different mechanisms. These findings indicate a synergistic effect of the bacterial combinations relative to the single strain and Lh-R0052-SLP treatments in resolving toll-like receptor 3 (TLR3)-induced inflammation in IEC and maintaining cellular homeostasis, reinforcing the rationale for using multi-strain formulations as a probiotic.
Comparison of kinesthetic and skin deformation feedback for mass rendering

Virtual and augmented reality systems that immerse users in a 3D environment could benefit from haptic (force and/or tactile) feedback to increase realism and task performance. A canonical task that cannot be achieved compellingly without haptic feedback is the grasp and lift of an object with mass. Traditional kinesthetic (force) feedback devices provide realistic physical interactions with virtual objects, but typically require large actuators, making them bulky and encumbering. In contrast, tactile feedback devices can use smaller actuators and may enable freer movement of a user in a virtual world. One form of tactile feedback, skin deformation feedback, has been previously shown to provide effective haptic feedback of force, stiffness, and friction. Here we compare human perception of mass via kinesthetic feedback and skin deformation feedback in a virtual environment. Participants grasp and lift two virtual blocks and attempt to equalize their masses by the method of adjustments. From the accuracy of this equalization, we determined that the Weber Fraction (the just noticeable difference in proportion to the original stimulus value) of virtual mass during a grasp and lift task was 0.11 for kinesthetic force feedback and 0.35 for skin deformation feedback. In addition, participants exhibited differences in exploratory procedures between the two types of feedback.
Hypoxia Imaging Endoscopy Equipped with Laser Light Source from Preclinical Live Animal Study to First-In-Human Subject Research

A goal in next-generation endoscopy is to develop functional imaging techniques to open up new opportunities for cancer diagnosis. Although spatial and temporal information on hypoxia is crucial for understanding cancer physiology and expected to be useful for cancer diagnosis, existing techniques using fluorescent indicators have limitations due to low spatial resolution and invasive administration. To overcome these problems, we developed an imaging technology based on hemoglobin oxygen saturation in both the tumor and surrounding mucosa using a laser endoscope system, and conducted the first human subject research for patients with aero-digestive tract cancer. The oxygen saturation map overlapped the images of cancerous lesions and indicated highly heterogeneous features of oxygen supply in the tumor. The hypoxic region of the tumor surface was found in both early cancer and cancer precursors. This technology illustrates a novel aspect of cancer biology as a potential biomarker and can be widely utilized in cancer diagnosis.
Dark Energy and Cosmic Curvature: Monte Carlo Markov Chain Approach

We use the Monte Carlo Markov chain method to explore the dark energy properties and the cosmic curvature by fitting two popular dark energy parameterizations to the observational data. The new 182 gold Type Ia supernova data and the ESSENCE data both give good constraints on the dark energy parameters and the cosmic curvature for the dark energy model w0 + waz/(1 + z) . The cosmic curvature is found to be | Ωk| ≲ 0.03. For the dark energy model w0 + waz/(1 + z)2, the ESSENCE data gives better constraints on the cosmic curvature, and we get | Ωk| ⩽ 0.02.
Abusive supervision and employees’ job performance: A multiple mediation model

We explored the relationship between abusive supervision (AS) and employee job performance (EJP) by conducting a survey of a group of employees ( N = 630) of Chinese public and private companies. We investigated possible mediation in the relationship by leadership justice, supervisory trust, and self-efficacy from three perspectives, namely, self-concept and individual socialization, organizational justice, and leader–member exchange. The results showed that there was a negative relationship between AS and EJP that was mediated by leadership justice, supervisory trust, and self-efficacy. We also found that the negative relationship between AS and EJP was affected by the joint mediating effect of leadership justice and supervisory trust. Implications for academicians and practitioners are discussed.
Unstable hyperplanes for Steiner bundles and multidimensional matrices

We study some properties of the natural action of $SL(V_0) \times. \times SL(V_p)$ on nondegenerate multidimensional complex matrices $A\in\P (V_0\otimes.\otimes V_p)$ of boundary format(in the sense of Gelfand, Kapranov and Zelevinsky); in particular we characterize the non stable ones,as the matrices which are in the orbit of a "triangular" matrix, and the matrices with a stabilizer containing $\C^*$, as those which are in the orbit of a "diagonal" matrix. For $p=2$ it turns out that a non degenerate matrix $A\in\P (V_0\otimes V_1\otimes V_2)$ detects a Steiner bundle $S_A$ (in the sense of Dolgachev and Kapranov) on the projective space $\P^{n}, n = dim (V_2)-1$. As a consequence we prove that the symmetry group of a Steiner bundle is contained in SL(2) and that the SL(2)-invariant Steiner bundles are exactly the bundles introduced by Schwarzenberger [Schw], which correspond to "identity" matrices. We can characterize the points of the moduli space of Steiner bundles which are stable for the action of $Aut(\P^n)$, answering in the first nontrivial case a question posed by Simpson. In the opposite direction we obtain some results about Steiner bundles which imply properties of matrices. For example the number of unstable hyperplanes of $S_A$ (counting multiplicities) produces an interesting discrete invariant of $A$, which can take the values $0, 1, 2, . ,\dim~V_0+1$ or $ \infty$; the $\infty$ case occurs if and only if $S_A$ is Schwarzenberger (and $A$ is an identity). Finally, the Gale transform for Steiner bundles introduced by Dolgachev and Kapranov under the classical name of association can be understood in this setting as the transposition operator on multidimensional matrices.
Severe Plasmodium falciparum Malaria Is Associated with Circulating Ultra-Large von Willebrand Multimers and ADAMTS13 Inhibition

Plasmodium falciparum infection results in adhesion of infected erythrocytes to blood vessel endothelium, and acute endothelial cell activation, together with sequestration of platelets and leucocytes. We have previously shown that patients with severe infection or fulminant cerebral malaria have significantly increased circulatory levels of the adhesive glycoprotein von Willebrand factor (VWF) and its propeptide, both of which are indices of endothelial cell activation. In this prospective study of patients from Ghana with severe (n = 20) and cerebral (n = 13) P. falciparum malaria, we demonstrate that increased plasma VWF antigen (VWF:Ag) level is associated with disproportionately increased VWF function. VWF collagen binding (VWF:CB) was significantly increased in patients with cerebral malaria and severe malaria (medians 7.6 and 7.0 IU/ml versus 1.9 IU/ml; p<0.005). This increased VWF:CB correlated with the presence of abnormal ultra-large VWF multimers in patient rather than control plasmas. Concomitant with the increase in VWF:Ag and VWF:CB was a significant persistent reduction in the activity of the VWF-specific cleaving protease ADAMTS13 (approximately 55% of normal; p<0.005). Mixing studies were performed using P. falciparum patient plasma and normal pooled plasma, in the presence or absence of exogenous recombinant ADAMTS13. These studies demonstrated that in malarial plasma, ADAMTS13 function was persistently inhibited in a time-dependent manner. Furthermore, this inhibitory effect was not associated with the presence of known inhibitors of ADAMTS13 enzymatic function (interleukin-6, free haemoglobin, factor VIII or thrombospondin-1). These novel findings suggest that severe P. falciparum infection is associated with acute endothelial cell activation, abnormal circulating ULVWF multimers, and a significant reduction in plasma ADAMTS13 function which is mediated at least in part by an unidentified inhibitor.
Comparison of Doppler echocardiography and right heart catheterization to assess pulmonary hypertension in systemic sclerosis.

Pulmonary hypertension (PHT) is an important complication of systemic sclerosis (SSc). Echocardiography can be used to detect PHT and, with Doppler echocardiography, the pulmonary arterial systolic pressure (PASP) can often be estimated. We have undertaken a study to compare echocardiographic assessment with right heart catheterization (RHC) in 33 SSc patients in whom clinical assessment [including ECG, chest X-ray, lung function tests and high-resolution computed tomography (HRCT) had raised strong suspicion of PHT. The mean (S.D.) interval between echocardiography and RHC was 1.8 (2.3) months. Twenty-one patients (64%) had PHT (PASP > or = 30 mmHg) on RHC, and echocardiography correctly identified 19 of these (sensitivity 90%). Of the 12 patients without PHT on RHC, nine were correctly identified by echocardiography (specificity 75%). The five incorrectly classified patients all had PASP in the borderline normal/abnormal range. The presence of tricuspid regurgitation allowed Doppler measurement of PASP in 20 patients (61%) and this correlated significantly with RHC values (r = 0.83, P < 0.001). We conclude that echocardiography is a reliable method for detecting PHT and it may be particularly useful for the early detection and monitoring of this potentially fatal complication in SSc.
Urbanization Without Growth: A Not-so-Uncommon Phenomenon

To find out why African countries' experience with urbanization and sustained growth appeared to differ from that of other countries, the authors investigated the determinants of urbanization across countries over 40 years. Rather than studying individuals' decisions to migrate, they relied on macroeconomic data and cross-country comparisons. A central hypothesis of their study: that individuals move (with varying degrees of ease) in response to economic incentives and opportunities. If location incentives are distorted, so is growth. The authors find that urbanization levels are closely correlated with levels of income. But urbanization continues even during periods of negative growth, carried by its own momentum, largely a function of the level of urbanization. From that viewpoint, Africa's urbanization without growth is not a puzzle. Factors other than income that help predict differences in levels of urbanization across countries include: a) income structure; b) education; c) rural-urban wage differentials; d) ethnic tensions; and e) civil disturbances. In addition, the relationship between economic incentives and urbanization is weaker in countries with fewer civil or political liberties. Factors other than initial urbanization level that help explain the speed of urbanization include: 1) The sector from which income growth is derived; 2) ethnic tensions; 3) civil disturbances and democracy (these two slow the pace of urbanization if all else is constant); 4) rural-urban wage differentials, whether they represent an urban bias or simply lower productivity in agriculture relative to other sectors. The weak relationship that this study shows between urbanization and traditionally accepted migration factors suggests that in Africa economists are overlooking part of the urbanization story. The fact that the informal sector appears to provide a significant source of income for urban migrants, coupled with the overlap between rural and urban activities, may shed light on the nature of urbanization in Africa.
3D GEO-INFORMATION INDOORS: STRUCTURING FOR EVACUATION

Interiors of buildings are often represented as two-dimensional spaces with attributes attached to them. Examples can be found everywhere, from architectural design plans to maps showing evacuation routes in emergency cases. Most of the navigation programs use primarily 2D plans for visualization and communication. Some exceptions are historical buildings and museums, which do offer navigation through textured, detailed 3D indoor models. However, these models are not structured with respect to the functionality of the building but largely with respect to the navigation/visualisation route. Structuring the interior is not a straight forward task, as many concurrent decompositions of a building have to be accommodated (e.g., functional, according to building structure, accessibility-wise), which are very dependent on the application. Furthermore the semantic/terminology is still not unified and in many cases ambiguous. A very typical example are inner open-air courts, which are open-air but inside the building. In this paper we present a semantic model of interior spaces. The structuring aims at facilitating calculation of evacuation routes and therefore particular building characteristics related to exit possibilities such as available doors and windows are considered as leading in the followed approach. The classification concept is used to build a graph for one of the buildings in the campus area. The geometry of the building and corresponding graph are organised in a geo-database management system (geo-DBMS)
Improving Throughput with Cascaded TCP Connections: the Logistical Session Layer

This paper describes a system designed to improve network performance and functionality in a way that is applicable from high-performance distributed computing to wireless and mobile networking. Our architecture captures the benefits of application-level routing while being designed as a general-purpose network service. We call our abstraction the Logistical Session Layer as it allows decisions about a flow’s path through the network to be made based on what can be thought of as network logistics. The “session” layer affords a conversation based on multiple transport-layer hops. We empirically examine the performance implications of the “cascaded” TCP connections that our approach facilitates.