Miracle-dz/UniFAR-FTUs huggingface dataset:
Measuring and Calculating Current Atmospheric Phosphorous and Nitrogen Loadings on Utah Lake Using Field Samples, Laboratory Methods, and Statistical Analysis: Implication for Water Quality Issues

Measuring and Calculating Current Atmospheric Phosphorous and Nitrogen Loadings on Utah Lake Using Field Samples, Laboratory Methods, and Statistical Analysis: Implication for Water Quality Issues Jacob Milton Olsen Department of Civil and Environmental Engineering, BYU Master of Science Atmospheric nutrient loading and transport though precipitation and dry deposition is one of the least understood yet one of the most important pathways of nutrient transport into many lakes. These nutrients, phosphorus and nitrogen, are essential for aquatic life and often play major roles in algae blooms that occur in lakes and reservoirs. Often heavy algal growth intensifies a variety of water quality problems. Utah Lake may be even more susceptible to atmospheric deposition due to its large surface area to volume ratio and proximity to Great Basin dust sources. In this study, eight months of atmospheric deposition data were collected and analyzed from five locations near Utah Lake. Geospatial maps were created to show the temporal distribution of phosphorus and nitrogen. Evaluation of the atmospheric deposition results indicate that between 8 to 350 tons of total phosphorus and 46 to 460 tons of dissolved inorganic nitrogen were deposited onto the surface of Utah Lake over an eight-month period. Both estimates were based on assuming that the deposition decreased exponentially from the sampling station to the middle of the lake. The large difference results from using only samples with no visible particles or insects present to give the low estimate and all samples to give the high estimate. These nutrient loading values are very significant in that it has been estimated that only about 17 tons year-1 of phosphorus and about 200 tons year-1 of nitrogen are needed to support a eutrophic level of algal growth in Utah Lake. Atmospheric deposition was found to be a major contributor in providing a eutrophic nutrient load to Utah Lake. Further, it is likely that the actual deposition loading is much higher than 8 tons per 8 months thus indicating that deposition alone adds a eutrophic phosphorus loading to the lake. Since conditions are similar in much of the Great Basin and other areas of Western United States, this seems to be a very significant finding relative to nutrient evaluation and feasible management scenarios. The results also indicate that one might expect to see more cyanobacteria blooms (Harmful Algal Blooms) in shallow ponds in this area if atmospheric deposition is the main source of nutrients, since N to P ratios are low and thus more situations arise where a shortage of ionic nitrogen favors these nitrogen-fixing cyanobacteria.
Antithrombotic Medication for Cardioembolic Stroke Prevention

Embolism of cardiac origin accounts for about 20% of ischemic strokes. Nonvalvular atrial fibrillation is the most frequent cause of cardioembolic stroke. Approximately 1% of population is affected by atrial fibrillation, and its prevalence is growing with ageing in the modern world. Strokes due to cardioembolism are in general severe and prone to early recurrence and have a higher long-term risk of recurrence and mortality. Despite its enormous preventive potential, continuous oral anticoagulation is prescribed for less than half of patients with atrial fibrillation who have risk factors for cardioembolism and no contraindications for anticoagulation. Available evidence does not support routine immediate anticoagulation of acute cardioembolic stroke. Anticoagulation therapy's associated risk of hemorrhage and monitoring requirements have encouraged the investigation of alternative therapies for individuals with atrial fibrillation. New anticoagulants being tested for prevention of stroke are low-molecular-weight heparins (LMWH), unfractionated heparin, factor Xa inhibitors, or direct thrombin inhibitors like dabigatran etexilate and rivaroxaban. The later exhibit stable pharmacokinetics obviating the need for coagulation monitoring or dose titration, and they lack clinically significant food or drug interaction. Moreover, they offer another potential that includes fixed dosing, oral administration, and rapid onset of action. There are several concerns regarding potential harm, including an increased risk for hepatotoxicity, clinically significant bleeding, and acute coronary events. Therefore, additional trials and postmarketing surveillance will be needed.
Omega-3 fatty acid supplementation decreases liver fat content in polycystic ovary syndrome: a randomized controlled trial employing proton magnetic resonance spectroscopy.

CONTEXT There is an association between nonalcoholic fatty liver disease (NAFLD) and the polycystic ovary syndrome (PCOS). Marine-derived omega-3 fatty acids have favorable effects on cardiovascular risk and could reduce liver fat in NAFLD. OBJECTIVE The primary aim of this study was to examine the effects of omega-3 fatty acids on liver fat in PCOS. The secondary aim was to assess their effects on traditional cardiovascular risk factors. DESIGN AND SETTING We conducted a randomized, crossover study at a tertiary cardiovascular research center. SUBJECTS Twenty-five women with PCOS (mean age, 32.7 yr; mean body mass index, 34.8 kg/m(2)) participated in the study. INTERVENTION We compared 4g/d of omega-3 fatty acids with placebo over 8 wk. MAIN OUTCOME MEASURES The primary outcome measure was hepatic fat content quantified using proton magnetic resonance spectroscopy. Secondary outcome measures included fasting lipids and blood pressure. RESULTS Omega-3 fatty acids significantly decreased liver fat content compared with placebo [10.2 (1.1) vs. 8.4 (0.9)%; P = 0.022]. There was also a reduction in triglycerides [1.19 (1.03-1.47) vs. 1.02 (0.93-1.18) mmol/liter; P = 0.002], systolic blood pressure [124.1 (12.1) vs. 122.3 (14.5) mm Hg; P = 0.018], and diastolic blood pressure [73.2 (8.4) vs. 69.7 (8.3) mm Hg; P = 0.005] with omega-3 fatty acids compared with placebo. Omega-3 fatty acids particularly decreased hepatic fat in women with hepatic steatosis, defined as liver fat percentage greater than 5% [18.2 (11.1) vs. 14.8 (9.3)%; P = 0.03]. CONCLUSIONS Omega-3 fatty acid supplementation has a beneficial effect on liver fat content and other cardiovascular risk factors in women with PCOS, including those with hepatic steatosis. Whether this translates into a reduction in cardiometabolic events warrants further study.
Describing functions of power electronics circuits using progressive analysis of circuit waveforms

This paper presents a technique for calculating the AC line-to-output and control-to-output transfer characteristics of DC/DC converters, in which the time instants switching from one topology to the next one are a priori unknown and are determined by threshold conditions (i.e., by the time evolution of the converter waveforms). Describing functions are defined for small perturbations in either the input voltage or the control signal. After injecting a sinusoidal perturbation at the frequency of interest into the converter, the fundamental component of the output spectrum is determined. The describing functions are thus evaluated and provide the required AC transfer characteristics. The proposed method is integrated with a previously developed time-domain simulation algorithm, which is based on monitoring the switches positions, allowing the simulator to find automatically the switching instants and topological sequence of operation. Different examples are illustrated, including a classical pulse-width-modulated (PWM) converter, a current-programmed PWM regulator, and a switched-capacitor converter. The simulated results are compared with the experimental measurements and the results in the available literature.
Proactive Handover in Heterogeneous Networks Using SIPs

In some areas, overlapping networks provide alternative wireless links like WLAN, GSM, 3G etc. Ideally, the user should be connected to the most attractive network any time according to predefined priorities. This is accomplished with automatic handover. The most likely commercial application of this type is designed for speech, and is using SIP to set up VoIP calls through WLAN networks or mobile networks. To make the handover time as short as possible is essential to make it attractive. This is best done by preparing the alternative networks before the handover is needed. This is called proactive handover. This paper suggests changes to some of the basic SIP messages that open for proactive handover in SIP and help reduce the delays when roaming.
Overcoming fragmentation in mobile Ad Hoc networks

We present an approach to multicast messages among highly mobile hosts in ad hoc networks. We suggest a new definition of a multicast that suits the special needs of inter-vehicle communication: rather than explicit identification, a multicast group is defined implicitly by location, speed, driving direction and time. As an example, we study a road accident that is reported to nearby vehicles. We focus on sparse deployment of the system which is likely to occur soon after the system is introduced to the market. In this state, the resulting ad hoc network tends to be disconnected. We tailor the proposed algorithm to overcome this problem of network fragmentation. Simulations show us the quality of the proposed protocol by measuring how many vehicles inside a multicast area are informed in time under various conditions.
Adaptive Feeding: Achieving Fast and Accurate Detections by Adaptively Combining Object Detectors

Object detection aims at high speed and accuracy simultaneously. However, fast models are usually less accurate, while accurate models cannot satisfy our need for speed. A fast model can be 10 times faster but 50% less accurate than an accurate model. In this paper, we propose Adaptive Feeding (AF) to combine a fast (but less accurate) detector and an accurate (but slow) detector, by adaptively determining whether an image is easy or hard and choosing an appropriate detector for it. In practice, we build a cascade of detectors, including the AF classifier which make the easy vs. hard decision and the two detectors. The AF classifier can be tuned to obtain different tradeoff between speed and accuracy, which has negligible training time and requires no additional training data. Experimental results on the PASCAL VOC, MS COCO and Caltech Pedestrian datasets confirm that AF has the ability to achieve comparable speed as the fast detector and comparable accuracy as the accurate one at the same time. As an example, by combining the fast SSD300 with the accurate SSD500 detector, AF leads to 50% speedup over SSD500 with the same precision on the VOC2007 test set.
At-The-Market ( ATM ) Offerings by Matthew

Facilitated in 2008, “At-The-Market” (ATM) equity offerings are direct share issuances to secondary market investors. Their popularity has increased dramatically, and in 2016 the number of ATMs and total proceeds of ATMs amounted to 63% and 28% of that for SEOs. ATMs forgo underwriters and shares are “dribbled-out” over many months rather than raised all at once. We find that firms choose between SEOs and ATMs in a manner that supports the costly certification hypothesis of Chemmanur and Fulghieri (1994). We also find that 65% of ATM proceeds are used to stockpile cash, compared to 84% of SEO proceeds.
The common ancestral core of vertebrate and fungal telomerase RNAs

Telomerase is a ribonucleoprotein with an intrinsic telomerase RNA (TER) component. Within yeasts, TER is remarkably large and presents little similarity in secondary structure to vertebrate or ciliate TERs. To better understand the evolution of fungal telomerase, we identified 74 TERs from Pezizomycotina and Taphrinomycotina subphyla, sister clades to budding yeasts. We initially identified TER from Neurospora crassa using a novel deep-sequencing–based approach, and homologous TER sequences from available fungal genome databases by computational searches. Remarkably, TERs from these non-yeast fungi have many attributes in common with vertebrate TERs. Comparative phylogenetic analysis of highly conserved regions within Pezizomycotina TERs revealed two core domains nearly identical in secondary structure to the pseudoknot and CR4/5 within vertebrate TERs. We then analyzed N. crassa and Schizosaccharomyces pombe telomerase reconstituted in vitro, and showed that the two RNA core domains in both systems can reconstitute activity in trans as two separate RNA fragments. Furthermore, the primer-extension pulse-chase analysis affirmed that the reconstituted N. crassa telomerase synthesizes TTAGGG repeats with high processivity, a common attribute of vertebrate telomerase. Overall, this study reveals the common ancestral cores of vertebrate and fungal TERs, and provides insights into the molecular evolution of fungal TER structure and function.
How Immunocontraception Can Contribute to Elephant Management in Small, Enclosed Reserves: Munyawana Population as a Case Study

Immunocontraception has been widely used as a management tool to reduce population growth in captive as well as wild populations of various fauna. We model the use of an individual-based rotational immunocontraception plan on a wild elephant, Loxodonta africana, population and quantify the social and reproductive advantages of this method of implementation using adaptive management. The use of immunocontraception on an individual, rotational basis stretches the inter-calving interval for each individual female elephant to a management-determined interval, preventing exposing females to unlimited long-term immunocontraception use (which may have as yet undocumented negative effects). Such rotational immunocontraception can effectively lower population growth rates, age the population, and alter the age structure. Furthermore, such structured intervention can simulate natural process such as predation or episodic catastrophic events (e.g., drought), which regulates calf recruitment within an abnormally structured population. A rotational immunocontraception plan is a feasible and useful elephant population management tool, especially in a small, enclosed conservation area. Such approaches should be considered for other long-lived, social species in enclosed areas where the long-term consequences of consistent contraception may be unknown.
Barriers to ICT adoption in SMEs: how to bridge the digital divide?

Purpose – The purpose of this paper is to report findings of a study conducted on micro and small enterprises (SMEs) from selected regions of Spain, Portugal and Poland, and to compare them with the results of a similar survey carried out in California (USA). The European and US research studies focus on issues regarding the use of information and communication technology (ICT) solutions by SMEs and digital divide phenomena which exist between SMEs and large corporations.Design/methodology/approach – The data collected during face‐to‐face interviews with SMEs' owner–managers and employees from Spain, Portugal, Poland and the USA were used for making a comparative analysis based on descriptive statistical methods. Analyzing the barriers that discourage SMEs from using information and communication technology (ICT) and e‐Business solutions in their business processes made it possible to identify the reasons for SMEs being on the “wrong side” of the digital divide.Findings – The paper argues that the main ba.
Leads and ridges in Arctic sea ice from RGPS data and a new tracking algorithm

Abstract. Leads and pressure ridges are dominant features of the Arctic sea ice cover. Not only do they affect heat loss and surface drag, but they also provide insight into the underlying physics of sea ice deformation. Due to their elongated shape they are referred to as linear kinematic features (LKFs). This paper introduces two methods that detect and track LKFs in sea ice deformation data and establish an LKF data set for the entire observing period of the RADARSAT Geophysical Processor System (RGPS). Both algorithms are available as open-source code and applicable to any gridded sea ice drift and deformation data. The LKF detection algorithm classifies pixels with higher deformation rates compared to the immediate environment as LKF pixels, divides the binary LKF map into small segments, and reconnects multiple segments into individual LKFs based on their distance and orientation relative to each other. The tracking algorithm uses sea ice drift information to estimate a first guess of LKF distribution and identifies tracked features by the degree of overlap between detected features and the first guess. An optimization of the parameters of both algorithms, as well as an extensive evaluation of both algorithms against handpicked features in a reference data set, is presented. A LKF data set is derived from RGPS deformation data for the years from 1996 to 2008 that enables a comprehensive description of LKFs. LKF densities and LKF intersection angles derived from this data set agree well with previous estimates. Further, a stretched exponential distribution of LKF length, an exponential tail in the distribution of LKF lifetimes, and a strong link to atmospheric drivers, here Arctic cyclones, are derived from the data set. Both algorithms are applied to output of a numerical sea ice model to compare the LKF intersection angles in a high-resolution Arctic sea ice simulation with the LKF data set.
Variability of Coronary Calcium Scores Throughout the Cardiac Cycle: Implications for the Appropriate Use of Electrocardiogram-Dose Modulation with Retrospectively Gated Computed Tomography

Objective:To study how much the calcium scores at various phases throughout the cardiac cycle deviate from the score in the most motionless phase during retrospectively electrocardiogram (ECG)-gated multidetector row computed tomography (MDCT) of the heart and to evaluate how to optimize ECG-based tube current modulation so that errors in calcium scoring can be minimized while dose savings can be maximized. Materials and Methods:In 73 subjects with known or suspected coronary artery disease we performed retrospectively ECG-gated 64-detector row computed tomography for calcium scoring. Four subjects were excluded after scanning because of breathing artifacts or lack of coronary calcification. The scans of 69 subjects (46 men, mean age 62 ± 6 years) were used for further analysis. Heart rate during the scan was recorded. In each patient, calcium scoring [Agatston score (AS), mass score (MS), and volume score, (VS)] was performed on 10 data sets reconstructed at 10%-intervals throughout the cardiac cycle. The most motionless phase was subjectively determined and used as the reference phase. For the score in each phase, deviation from the score in the reference phase was determined. An ECG-simulator was used to determine the amount of dose saving while scanning with dose modulation and applying diagnostic dose during 1 or several phases. Results:Mean heart rate was 63 (±13) beats per minute (bpm). In 51% of patients the reference phase was the 70% phase. Using the calcium score in the 70% phase (mid-diastole) instead of the reference at heart rates below 70 bpm would have induced a median score deviation of 0% [interquartile range: 0%–6% (AS, MS, and VS)] and using the calcium score in the 40% phase (end-systole) at heart rates ≥70 bpm would also have induced a median score deviation of 0% [interquartile range: 0%–7% (AS), 0%–5% (MS), and 0%–3% (VS)]. Errors in calcium scores of more than 10% occur in around 10% of subjects for all 3 scoring algorithms. Dose savings increased with lower heart rates and shorter application of diagnostic dose. Conclusions:The optimum phases for dose modulation are 70% (mid-diastole) at heart rates below 70 bpm and 40% (end-systole) at heart rates above 70 bpm. Under these conditions dose saving is maximum and a median error of 0% is found for the various calcium scoring techniques with score errors of more than 10% in around 10% of subjects.
Novel Type of ADP-Forming Acetyl Coenzyme A Synthetase in Hyperthermophilic Archaea: Heterologous Expression and Characterization of Isoenzymes from the Sulfate Reducer Archaeoglobus fulgidus and the Methanogen Methanococcus jannaschii

ABSTRACT Acetyl coenzyme A (CoA) synthetase (ADP forming) (ACD) represents a novel enzyme of acetate formation and energy conservation (acetyl-CoA + ADP + Pi ⇌ acetate + ATP + CoA) in Archaea and eukaryotic protists. The only characterized ACD in archaea, two isoenzymes from the hyperthermophile Pyrococcus furiosus, constitute 145-kDa heterotetramers (α2, β2). The coding genes for the α and β subunits are located at different sites in the P. furiosus chromosome. Based on significant sequence similarity of the P. furiosus genes, five open reading frames (ORFs) encoding putative ACD were identified in the genome of the hyperthermophilic sulfate-reducing archaeon Archaeoglobus fulgidus and one ORF was identified in the hyperthermophilic methanogen Methanococcus jannaschii. The ORFs constitute fusions of the homologous P. furiosus genes encoding the α and β subunits. Two ORFs, AF1211 and AF1938, of A. fulgidus and ORF MJ0590 of M. jannaschii were cloned and functionally overexpressed in Escherichia coli. The purified recombinant proteins were characterized as distinctive isoenzymes of ACD with different substrate specificities. In contrast to the Pyrococcus ACD, the ACDs of Archaeoglobus and Methanococcus constitute homodimers of about 140 kDa composed of two identical 70-kDa subunits, which represent fusions of the homologous P. furiosus α and β subunits in an αβ (AF1211 and MJ0590) or βα (AF1938) orientation. The data indicate that A. fulgidus and M. jannaschii contains a novel type of ADP-forming acetyl-CoA synthetase in Archaea, in which the subunit polypeptides and their coding genes are fused.
Left-Right Function of dmrt2 Genes Is Not Conserved between Zebrafish and Mouse

Background Members of the Dmrt family, generally associated with sex determination, were shown to be involved in several other functions during embryonic development. Dmrt2 has been studied in the context of zebrafish development where, due to a duplication event, two paralog genes dmrt2a and dmrt2b are present. Both zebrafish dmrt2a/terra and dmrt2b are important to regulate left-right patterning in the lateral plate mesoderm. In addition, dmrt2a/terra is necessary for symmetric somite formation while dmrt2b regulates somite differentiation impacting on slow muscle development. One dmrt2 gene is also expressed in the mouse embryo, where it is necessary for somite differentiation but with an impact on axial skeleton development. However, nothing was known about its role during left-right patterning in the lateral plate mesoderm or in the symmetric synchronization of somite formation. Methodology/Principal Findings Using a dmrt2 mutant mouse line, we show that this gene is not involved in symmetric somite formation and does not regulate the laterality pathway that controls left-right asymmetric organ positioning. We reveal that dmrt2a/terra is present in the zebrafish laterality organ, the Kupffer's vesicle, while its homologue is excluded from the mouse equivalent structure, the node. On the basis of evolutionary sub-functionalization and neo-functionalization theories we discuss this absence of functional conservation. Conclusions/Significance Our results show that the role of dmrt2 gene is not conserved during zebrafish and mouse embryonic development.