Miracle-dz/UniFAR-FTUs huggingface dataset:
Non-additive modulation of synaptic transmission by serotonin, adenosine, and cholinergic modulators in the sensory thalamus

The thalamus relays sensory information to the cortex. Oscillatory activities of the thalamocortical network are modulated by monoamines, acetylcholine, and adenosine, and could be the key features characteristic of different vigilance states. Although the thalamus is almost always subject to the actions of more than just one neuromodulators, reports on the modulatory effect of coexisting neuromodulators on thalamic synaptic transmission are unexpectedly scarce. We found that, if present alone, monoamine or adenosine decreases retinothalamic synaptic strength and short-term depression, whereas cholinergic modulators generally enhance postsynaptic response to presynaptic activity. However, coexistence of different modulators tends to produce non-additive effect, not predictable based on the action of individual modulators. Acetylcholine, acting via nicotinic receptors, can interact with either serotonin or adenosine to abolish most short-term synaptic depression. Moreover, the coexistence of adenosine and monoamine, with or without acetylcholine, results in robustly decreased synaptic strength and transforms short-term synaptic depression to facilitation. These findings are consistent with a view that acetylcholine is essential for an “enriched” sensory flow through the thalamus, and the flow is trimmed down by concomitant monoamine or adenosine (presumably for the wakefulness and rapid-eye movement, or REM, sleep states, respectively). In contrast, concomitant adenosine and monoamine would lead to a markedly “deprived” (and high-pass filtered) sensory flow, and thus the dramatic decrease of monoamine may constitute the basic demarcation between non-REM and REM sleep. The collective actions of different neuromodulators on thalamic synaptic transmission thus could be indispensable for the understanding of network responsiveness in different vigilance states.
Norms and the Theory of the Firm

This paper discusses some of the attempts economists have made in the last ten years or so to integrate norms into the theory of the firm. The paper argues that (a) although norms are undoubtedly very important both inside and between firms, incorporating them into the theory has been very difficult and is likely to continue to be so in the near future; (b) so far norms have not added a great deal to our understanding of such issues as the determinants of firm boundaries (the 'make-or-buy' decision) that is, at this point a norm-free theory of the firm and a norm-rich theory of the firm don't seem to have very different predictions.
Pathway‐specific plasticity in the human spinal cord

The aim of the present study was to artificially induce plasticity in the human spinal cord and evaluate whether this plasticity is pathway specific. For this purpose, a technique called paired associative stimulation (PAS) was applied. Volleys evoked by transcranial magnetic stimulation over the primary motor cortex and peripheral nerve stimulation of the nervus tibialis in the popliteal fossa were timed to coincide at the spinal level. The transmission of different corticospinal projections was assessed before and after PAS using conditioned H‐reflexes. Different groups of healthy volunteers (28 ± 5 years) were tested; intervention groups 1 (n = 9) and 2 (n = 8) received spinal PAS (360 paired stimuli) and the induced effects were evaluated using cortical (group 1) or cervicomedullary (group 2) conditioning of musculus soleus H‐reflexes. After spinal PAS, the conditioned H‐reflexes were significantly facilitated when tested with cortical and cervicomedullary stimulation. The effect of the latter technique is independent of changes in the excitability of cortical neurons. Therefore, the finding that conditioned H‐reflexes were increased after spinal PAS when tested with both cortical and cervicomedullary stimulation suggests that neural plasticity was induced within the spinal cord. The facilitation could only be observed for specific inter‐stimulus intervals between volleys induced by peripheral nerve stimulation and transcranial magnetic stimulation. As the specific inter‐stimulus intervals were assumed to relate to transmission within specific motor pathways, it is argued that changes in the corticospinal transmission were pathway‐specific. These findings may be helpful in inducing and assessing neural plasticity in pathological conditions like spinal cord injuries.
BIASED DARK ENERGY CONSTRAINTS FROM NEGLECTING REDUCED SHEAR IN WEAK-LENSING SURVEYS

The weak gravitational lensing of distant galaxies by a large-scale structure is expected to become a powerful probe of dark energy. By measuring the ellipticities of large number of background galaxies, the subtle gravitational distortion called “cosmic shear” can be measured and used to constrain dark energy parameters. The observed galaxy ellipticities, however, are induced not by shear but by reduced shear, which also accounts for slight magnifications of the images. This distinction is negligible for present weak-lensing surveys, but it will become more important as we improve our ability to measure and understand small-angle cosmic shear modes. I calculate the discrepancy between shear and reduced shear in the context of power spectra and cross spectra, finding the difference could be as high as 10% on the smallest accessible angular scales. I estimate how this difference will bias dark energy parameters obtained from two weak-lensing methods: weak-lensing tomography and the shear ratio method known as offset-linear scaling. For weak-lensing tomography, ignoring the effects of reduced shear will cause future surveys considered by the Dark Energy Task Force to measure dark energy parameters that are biased by amounts comparable to their error bars. I advocate that reduced shear be properly accounted for in such surveys, and I provide a semi-analytic formula for doing so. Since reduced shear cross spectra do not follow an offset-linear scaling relation, the shear ratio method is similarly biased but with smaller significance.
On the Effect of Relaxation in the Convergence and Quality of Statistical Image Reconstruction for Emission Tomography Using Block-Iterative Algorithms

Relaxation is widely recognized as a useful tool for providing convergence in block-iterative algorithms [1], [2], [6]. In the present article we give new results on the convergence of RAMLA (Row Action Maximum Likelihood Algorithm) [2], filling some important theoretical gaps. Furthermore, because RAMLA and OS-EM (Ordered Subsets - Expectation Maximization) [4] are the algorithms for statistical reconstruction currently being used in commercial emission tomography scanners, we present a comparison between them from the viewpoint of a specific imaging task. Our experiments show the importance of relaxation to improve image quality.
Synergistic Effects of Vascular Endothelial Growth Factor on Bone Morphogenetic Proteins Induced Bone Formation In Vivo: Influencing Factors and Future Research Directions

Vascular endothelial growth factor (VEGF) and bone morphogenetic proteins (BMPs), as key mediators in angiogenesis and osteogenesis, are used in a combined delivery manner as a novel strategy in bone tissue engineering. VEGF has the potential to enhance BMPs induced bone formation. Both gene delivery and material-based delivery systems were incorporated in previous studies to investigate the synergistic effects of VEGF and BMPs. However, their results were controversial due to variation of methods incorporated in different studies. Factors influencing the synergistic effects of VEGF on BMPs induced bone formation were identified and analyzed in this review to reduce confusion on this issue. The potential mechanisms and directions of future studies were also proposed here. Further investigating mechanisms of the synergistic effects and optimizing these influencing factors will help to generate more effective bone regeneration.
Statistical Reporting Errors and Collaboration on Statistical Analyses in Psychological Science

Statistical analysis is error prone. A best practice for researchers using statistics would therefore be to share data among co-authors, allowing double-checking of executed tasks just as co-pilots do in aviation. To document the extent to which this ‘co-piloting’ currently occurs in psychology, we surveyed the authors of 697 articles published in six top psychology journals and asked them whether they had collaborated on four aspects of analyzing data and reporting results, and whether the described data had been shared between the authors. We acquired responses for 49.6% of the articles and found that co-piloting on statistical analysis and reporting results is quite uncommon among psychologists, while data sharing among co-authors seems reasonably but not completely standard. We then used an automated procedure to study the prevalence of statistical reporting errors in the articles in our sample and examined the relationship between reporting errors and co-piloting. Overall, 63% of the articles contained at least one p-value that was inconsistent with the reported test statistic and the accompanying degrees of freedom, and 20% of the articles contained at least one p-value that was inconsistent to such a degree that it may have affected decisions about statistical significance. Overall, the probability that a given p-value was inconsistent was over 10%. Co-piloting was not found to be associated with reporting errors.
WarpLDA: a Cache Efficient O(1) Algorithm for Latent Dirichlet Allocation

Developing efficient and scalable algorithms for Latent Dirichlet Allocation (LDA) is of wide interest for many applications. Previous work has developed an O(1) Metropolis-Hastings sampling method for each token. However, the performance is far from being optimal due to random accesses to the parameter matrices and frequent cache misses. In this paper, we first carefully analyze the memory access efficiency of existing algorithms for LDA by the scope of random access, which is the size of the memory region in which random accesses fall, within a short period of time. We then develop WarpLDA, an LDA sampler which achieves both the best O(1) time complexity per token and the best O(K) scope of random access. Our empirical results in a wide range of testing conditions demonstrate that WarpLDA is consistently 5-15x faster than the state-of-the-art Metropolis-Hastings based LightLDA, and is comparable or faster than the sparsity aware F+LDA. With WarpLDA, users can learn up to one million topics from hundreds of millions of documents in a few hours, at an unprecedentedly throughput of 11G tokens per second.
Analyzing large DDoS attacks using multiple data sources

We present a measurement study analyzing DDoS attacks from multiple data sources, relying on both direct measurements of flow-level information, and more traditional indirect measurements using backscatter analysis. Understanding the nature of DDoS attacks is critically important to the development of effective counter measures to this pressing problem. While much of the community's current understanding of DDoS attacks result from indirect measurements, our analysis suggests that such studies do not give a comprehensive view of DDoS attacks witnessed in today's Internet. Specifically, our results suggest little use of address spoofing by attackers, which imply that such attacks will be invisible to indirect backscatter measurement techniques. Further, at the detailed packet-level characterization (e.g., attack destination ports), there are significant differences between direct and indirect measurements. Thus, there is tremendous value in moving towards direct observations to better understand DDoS attacks. Direct measurements additionally provide information inaccessible to indirect measurements, enabling us to better understand how to defend against attacks. We find that for 70% of the attacks fewer than 50 source ASes are involved and a relatively small number of ASes produce nearly 72% of the total attack volume. This suggests that network providers can reduce a substantial volume of malicious traffic with targeted deployment of DDoS defenses.
Accurate Realizations of the Ionized Gas in Galaxy Clusters: Calibrating Feedback

Using the full, three-dimensional potential of galaxy cluster halos (drawn from an N-body simulation of the current, most favored cosmology), the distribution of the X-ray-emitting gas is found by assuming a polytropic equation of state and hydrostatic equilibrium with constraints from conservation of energy and pressure balance at the cluster boundary. The resulting properties of the gas for these simulated redshift zero clusters (the temperature distribution, mass-temperature and luminosity-temperature relations, and the gas fraction) are compared with observations in the X-ray of nearby clusters. The observed properties are reproduced only under the assumption that substantial energy injection from nongravitational sources has occurred. Our model does not specify the source, but star formation and active galactic nuclei (AGNs) may be capable of providing this energy, which amounts to (3-5) × 10-5 of the rest mass in stars (assuming 10% of the gas initially in the cluster forms stars). With the method described here, it is possible to generate realistic X-ray and Sunyaev-Zel'dovich cluster maps and catalogs from N-body simulations with the distributions of internal halo properties (and their trends with mass, location, and time) taken into account.
Secondary Prevention after Minor Stroke and TIA - Usual Care and Development of a Support Program

Background Effective methods of secondary prevention after stroke or TIA are available but adherence to recommended evidence-based treatments is often poor. The study aimed to determine the quality of secondary prevention in usual care and to develop a stepwise modeled support program. Methods Two consecutive cohorts of patients with acute minor stroke or TIA undergoing usual outpatient care versus a secondary prevention program were compared. Risk factor control and medication adherence were assessed in 6-month follow-ups (6M-FU). Usual care consisted of detailed information concerning vascular risk factor targets given at discharge and regular outpatient care by primary care physicians. The stepwise modeled support program additionally employed up to four outpatient appointments. A combination of educational and behavioral strategies was employed. Results 168 patients in the observational cohort who stated their openness to participate in a prevention program (mean age 64.7 y, admission blood pressure (BP): 155/84 mmHg) and 173 patients participating in the support program (mean age 67.6 y, BP: 161/84 mmHg) were assessed at 6 months. Proportions of patients with BP according to guidelines were 50% in usual-care and 77% in the support program (p<0.01). LDL<100 mg/dl was measured in 62 versus 71% (p = 0.12). Proportions of patients who stopped smoking were 50 versus 79% (p<0.01). 72 versus 89% of patients with atrial fibrillation were on oral anticoagulation (p = 0.09). Conclusions Risk factor control remains unsatisfactory in usual care. Targets of secondary prevention were met more often within the supported cohort. Effects on (cerebro-)vascular recurrence rates are going to be assessed in a multicenter randomized trial.
Comparing the Efficacy of Latanoprost (0.005%), Bimatoprost (0.03%), Travoprost (0.004%), and Timolol (0.5%) in the Treatment of Primary Open Angle Glaucoma

Purpose To compare the efficacy and safety of latanoprost, bimatoprost, travoprost and timolol in reducing intraocular pressure (IOP) in patients with primary open angle glaucoma. Methods This was a prospective study conducted at a tertiary-care centre. One hundred and forty patients with newly diagnosed primary open angle glaucoma were randomly assigned to treatment with latanoprost (0.005%), bimatoprost (0.03%), travoprost (0.004%) or timolol gel (0.5%); 35 patients were assigned to each group. All patients were followed for 2, 6, and 12 weeks. The main outcome measure studied was the change in IOP at week 12 from the baseline values. Safety measures included recording of adverse events. Results The mean IOP reduction from baseline at week 12 was significantly more with bimatoprost (8.8 mmHg, 35.9%) than with latanoprost (7.3 mmHg, 29.9%), travoprost (7.6 mmHg, 30.8%) or timolol (6.7 mmHg, 26.6%) (ANOVA and Student's t-tests, p < 0.001). Among the prostaglandins studied, bimatoprost produced a maximum reduction in IOP (-2.71; 95% confidence interval [CI], -2.25 to -3.18) followed by travoprost (-1.27; 95% CI, -0.81 to -1.27) and latanoprost (-1.25; 95% CI, -0.79 to -1.71); these values were significant when compared to timolol at week 12 (Bonferroni test, p < 0.001). Latanoprost and travoprost were comparable in their ability to reduce IOP at each patient visit. Ocular adverse-events were found in almost equal proportion in patients treated with bimatoprost (41.3%) and travoprost (41.9%), with a higher incidence of conjunctival hyperemia (24.1%) seen in the bimatoprost group. Timolol produced a significant drop in heart rate (p < 0.001) at week 12 when compared to the baseline measurements. Conclusions Bimatoprost showed greater efficacy when compared to the other prostaglandins, and timolol was the most efficacious at lowering the IOP. Conjunctional hyperemia was mainly seen with bimatoprost. However, the drug was tolerated well and found to be safe.
An Endomorphism of the Khovanov Invariant

We construct an endomorphism of the Khovanov invariant to prove H-thinness and pairing phenomena of the invariants for alternating links. As a consequence, it follows that the Khovanov invariant of an oriented nonsplit alternating link is determined by its Jones polynomial, signature, and the linking numbers of its components.
Defending against large-scale crawls in online social networks

Thwarting large-scale crawls of user profiles in online social networks (OSNs) like Facebook and Renren is in the interest of both the users and the operators of these sites. OSN users wish to maintain control over their personal information, and OSN operators wish to protect their business assets and reputation. Existing rate-limiting techniques are ineffective against crawlers with many accounts, be they fake accounts (also known as Sybils) or compromised accounts of real users obtained on the black market. We propose Genie, a system that can be deployed by OSN operators to defend against crawlers in large-scale OSNs. Genie exploits the fact that the browsing patterns of honest users and crawlers are very different: even a crawler with access to many accounts needs to make many more profile views per account than an honest user, and view profiles of users that are more distant in the social network. Experiments using real-world data gathered from a popular OSN show that Genie frustrates large-scale crawling while rarely impacting honest users; the few honest users who are affected can recover easily by adding a few friend links.
Cycles for asymptotic solutions and Weyl group

In this paper cycles for asymptotic solutions for Heckman-Opdam hypergeometric system of type $A_n$ are described. Cycles are enumerated by elements of symmetric group. Leading asymptotic and leading coefficient are calculated. Value of certain multiple integral over special cycles is calculated with the help of result of Opdam.
Performance of UN Military Observer Teams: Does Victim Proximity Escalate Commitment to Saving Lives?

A field experiment examined the tactical peacekeeping behaviors of military-officer teams undergoing training as United Nations military observers. Teams encountered a simulated human-rights violation where two civilians were being abused. Proximity of the female civilian to the team leader was manipulated and significantly influenced teams' commitment to saving the civilians' lives. Proximity increased the frequency of behaviors that were specifically oriented toward saving the civilians' lives and did not increase confrontational behavior. Finally, trainees' performance assessments were lower if they intervened but failed to save lives than if they did little to intervene and also failed to save lives.
The history of couple therapy: a millennial review.

In this article, we review the major conceptual and clinical influences and trends in the history of couple therapy to date, and also chronicle the history of research on couple therapy. The evolving patterns in theory and practice are reviewed as having progressed through four distinctive phases: Phase I--Atheoretical Marriage Counseling Formation (1930-1963); Phase II--Psychoanalytic Experimentation (1931-1966); Phase III--Family Therapy Incorporation (1963-1985); and Phase IV--Refinement, Extension, Diversification, and Integration (1986-present). The history of research in the field is described as having passed through three phases: Phase I--A Technique in Search of Some Data (1930-1974), Phase II--Irrational(? ) Exuberance (1975-1992), and Phase III--Caution and Extension (1993-present). The article concludes with the identification of Four Great Historical Ironies in the History of Couple Therapy.
Clinical Ophthalmology Dovepress Evaluation of Choroidal Thickness Changes after Phacoemulsification Surgery

hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms Purpose: The aim of the study was to analyze the effects of uneventful phacoemulsification surgery on choroidal thickness (CT) using spectral domain optical coherence tomography (SD-OCT). Methods: In this prospective study, 38 eyes of 38 patients having phacoemulsification surgery were included. All patients underwent detailed ophthalmologic examination, including preo-perative axial length (AXL) measurement with optical biometry and intraocular pressure (IOP) measurement preoperatively and 1 month postoperatively. The CT was measured perpendicularly at the fovea and 1.5 mm temporal, 3.0 mm temporal, 1.5 mm nasal, and 3.0 mm nasal using SD-OCT preoperatively and 1 month postoperatively. Changes in the CT after surgery and correlation of this change with age, AXL, preoperative IOP, and IOP change were evaluated. Results: There was a statistically significant increase in the CT at all regions evaluated. This increment was more prominent in the nasal and subfoveal regions. The IOP decreased significantly 1 month after surgery (16.14±4.94 mmHg vs 13.91±4.86 mmHg; P,0.001). The change in IOP was correlated with the CT changes at all regions, whereas age, AXL, and preoperative IOP had no significant correlations with the changes in CT. Conclusion: Phacoemulsification surgery may cause significant increase in CT, which is correlated with surgery-induced IOP change in the short term. Long-term follow-up of eyes having phacoemulsification surgery may provide further insight into the effects of cataract surgery on the choroid.
BOUNDED ORBITS OF NONQUASIUNIPOTENT FLOWS ON HOMOGENEOUS SPACES

Let {gt} be a nonquasiunipotent one-parameter subgroup of a connected semisimple Lie group G without compact factors; we prove that the set of points in a homogeneous spaceG/Γ (Γ an irreducible lattice inG) with bounded {gt}-trajectories has full Hausdorff dimension. Using this we give necessary and sufficient conditions for this property to hold for any Lie group G and any lattice Γ in G.