Miracle-dz/UniFAR-FTUs huggingface dataset:
Acute Lipopolysaccharide Switches the Selection of Maternal Behavior to Predatory Behavior in Female Rats

Objectives: A common problem during the postpartum period and during lactation is being affected by infection due to Gram-negative bacteria. In this situation, a sick mother needs to choose between caring for her pups or the need for survival. This study analyzed the effects of lipopolysaccharide (LPS)-induced sickness behavior on selection between maternal behavior (MB) and predatory behavior (PB) in lactating rats. To assess the LPS-induced sickness behavior, the plasma tumor necrosis factor-α (TNF-α) levels were measured. Methods: Lactating rats received 100 µg/kg LPS or saline solution on day 5 or 6 of lactation, 2 h before testing. Five pups and 5 cockroaches were introduced to the experimental cage at the same time and maternal and PB were observed for 30 min. The MB was measured by the pup contact, grouping, grooming, and kyphosis and the PB by contacting, eating, and foraging insects. General maternal activity was also observed, including exploration, self-grooming, and immobility. Immediately after the observations, blood was collected to measure the plasma TNF-α levels. Results: LPS administration reduced the time and frequency of pup contact, grouping, grooming, and kyphosis, with an increase in the latency to first pup contact and grouping. With regard to PB, the time of foraging and eating insects increased, and the latencies to first insect contact, eating insects, and foraging decreased. With regard to general maternal activity, immobility time and TNF-α levels increased in the LPS-treated group. Conclusions: LPS exposure switched MB to PB, prioritizing maternal survival. Thus, in more favorable situations, these rats may have new offspring and therefore her species would survive for long.
A 2.6mm2 0.19nJ/pixel VP9 and multi-standard decoder LSI for Android 4K TV applications

A lower power and area efficient VP9 and multi-standard video decoder chip is first-reported for Android 4K TV. It supports prevalent MPEG-x, VP-x, RMx, WMV-x and H.26x series video standards in a single chip. Three high-throughput techniques, look-ahead re-mapping, early stage pipeline and dynamic-scheduled bus translation, are proposed. They cuts the processing times by 51.2% compared to the state-of-the-art design [4]. Moreover, two area-efficient techniques, hybrid backward probability update and tile-to-raster scan ordering, are designed to reduce the internal memory size by 10%. A mass-production chip is fabricated in a 28nm CMOS technology with an energy efficiency of 0.19nJ/pixel and an area of 2.6mm2. Compared to the dual-core decoder design [4], this work achieves the identical performance (4K@60fps) with single core which cut one-half of chip area.
Computational ‘microscopy’ of cellular membranes

ABSTRACT Computational ‘microscopy’ refers to the use of computational resources to simulate the dynamics of a molecular system. Tuned to cell membranes, this computational ‘microscopy’ technique is able to capture the interplay between lipids and proteins at a spatio-temporal resolution that is unmatched by other methods. Recent advances allow us to zoom out from individual atoms and molecules to supramolecular complexes and subcellular compartments that contain tens of millions of particles, and to capture the complexity of the crowded environment of real cell membranes. This Commentary gives an overview of the main concepts of computational ‘microscopy’ and describes the state-of-the-art methods used to model cell membrane processes. We illustrate the power of computational modelling approaches by providing a few in-depth examples of large-scale simulations that move up from molecular descriptions into the subcellular arena. We end with an outlook towards modelling a complete cell in silico. Summary: Computational modelling, or ‘microscopy’, has emerged as a powerful tool to study cell membranes across a broad range of resolutions, complementing experimental microscopy methods.
Rational iterative feedforward tuning: Approaches, stable inversion, and experimental comparison

Feedforward control plays a key role in achieving high performance for industrial motion systems that perform non-repeating motion tasks. Recently, learning techniques have been proposed to further improve both performance and robustness to non-repeating tasks by using a rational feedforward basis. The aim of this paper is to propose a unifying framework which connects these approaches. Experimental results on an industrial motion system validate the approaches and illustrate benefits of rational feedforward tuning in motion systems, including pre- and post-actuation through stable inversion.
Molecular Characterization of Cronobacter Lipopolysaccharide O-Antigen Gene Clusters and Development of Serotype-Specific PCR Assays

ABSTRACT Cronobacter (formerly Enterobacter sakazakii) is a recently defined genus consisting of six species, C. sakazakii, C. malonaticus, C. dublinensis, C. muytjensii, C. turicensis, and Cronobacter genomospecies 1. In this study, MboII restriction fragment length polymorphism (RFLP) patterns of O-antigen gene clusters, located between galF and gnd, were used to identify serotypes in Cronobacter spp. Seven O-antigen RFLP clusters were generated, including three C. sakazakii clusters, previously identified as serotypes O1, O2, and O3. The O-antigen regions of six strains with unique RFLP patterns, including two C. sakazakii strains, two C. malonaticus strains, one C. turicensis strain, and one C. muytjensii strain, revealed three O-antigen gene clusters shared among Cronobacter species. PCR assays were developed, targeting the wzx O-antigen polymerase gene, and used to screen 231 Cronobacter strains to determine the frequency of these newly identified serotypes.
The ZrfC alkaline zinc transporter is required for Aspergillus fumigatus virulence and its growth in the presence of the Zn/Mn‐chelating protein calprotectin

Aspergillus fumigatus can invade the lungs of immunocompromised individuals causing a life‐threatening disease called invasive pulmonary aspergillosis (IPA). To grow in the lungs, A. fumigatus obtains from the host all nutrients, including zinc. In living tissues, however, most zinc is tightly bound to zinc‐binding proteins. Moreover, during infection the bioavailability of zinc can be further decreased by calprotectin, an antimicrobial Zn/Mn‐chelating protein that is released by neutrophils in abscesses. Nevertheless, A. fumigatus manages to uptake zinc from and grow within the lungs of susceptible individuals. Thus, in this study we investigated the role of the zrfA, zrfB and zrfC genes, encoding plasma membrane zinc transporters, in A. fumigatus virulence. We showed that zrfC is essential for virulence in the absence of zrfA and zrfB, which contribute to fungal pathogenesis to a lesser extent than zrfC and are dispensable for virulence in the presence of zrfC. The special ability of ZrfC to scavenge and uptake zinc efficiently from lungtissue depended on its N‐terminus, which is absent in the ZrfA and ZrfB transporters. In addition, under Zn‐ and/or Mn‐limiting conditions zrfC enables A. fumigatus to grow in the presence of calprotectin, which is detected in fungal abscesses of non‐leucopenic animals. This study extends our knowledge about the pathobiology of A. fumigatus and suggests that fungal zinc uptake could be a promising target for new antifungals.
Enhanced Solar‐to‐Hydrogen Generation with Broadband Epsilon‐Near‐Zero Nanostructured Photocatalysts

The direct conversion of solar energy into fuels or feedstock is an attractive approach to address increasing demand of renewable energy sources. Photocatalytic systems relying on the direct photoexcitation of metals have been explored to this end, a strategy that exploits the decay of plasmonic resonances into hot carriers. An efficient hot carrier generation and collection requires, ideally, their generation to be enclosed within few tens of nanometers at the metal interface, but it is challenging to achieve this across the broadband solar spectrum. Here the authors demonstrate a new photocatalyst for hydrogen evolution based on metal epsilon‐near‐zero metamaterials. The authors have designed these to achieve broadband strong light confinement at the metal interface across the entire solar spectrum. Using electron energy loss spectroscopy, the authors prove that hot carriers are generated in a broadband fashion within 10 nm in this system. The resulting photocatalyst achieves a hydrogen production rate of 9.5 µmol h−1 cm−2 that exceeds, by a factor of 3.2, that of the best previously reported plasmonic‐based photocatalysts for the dissociation of H2 with 50 h stable operation.
Reactive Vascular Lesions Treated Using Ethanolamine Oleate Sclerotherapy

BACKGROUND Ethanolamine oleate (EO) is used infrequently in dermatology, but is used to treat vascular lesions such as esophageal varices, varicose veins, and congenital vascular malformations. OBJECTIVE To evaluate the efficacy and safety of EO for treating reactive vascular lesions. MATERIALS AND METHODS Patients with reactive vascular lesions, such as pyogenic granulomas or venous lakes, were enrolled. EO was used as a sclerosing agent in a 1:1 dilution with normal saline. According to the response, treatment was repeated with EO with less or no dilution. The treatment response was scored as complete remission (CR), moderate improvement (MI), or no change according to the clinical results; any side effects were recorded. RESULTS The efficacy of EO was evaluated in 21 patients (16 pyogenic granulomas and 5 venous lakes). The diameters of the lesions ranged from 0.3 to 1.0 cm. The mean number of EO injections was 1.6 (range 1–4). A CR was achieved in 95% of the reactive vascular lesions (20 CR, 1 MI). Two episodes of transient pain occurred. CONCLUSION EO is an excellent sclerosing agent for treating reactive vascular lesions, and it may be an alternative therapy for vascular lesions in dermatology. The authors have indicated no significant interest with commercial supporters.
Welsh-language provision on party websites during the 2010 UK General Election

The internet is now an important element of most political parties' communication strategies during elections. While online communication might be claimed to enable smaller parties and marginal voices to compete more effectively with major parties, it might also enable minority languages to challenge the existing dominance of majority languages in traditional political communication. This paper explores Welsh-language provision on the websites of the 18 parties which fielded candidates in Wales during the 2010 UK General Election. Three websites making bilingual provision are examined in greater detail, considering the Welsh-language experience in terms of information seeking tasks, the use of web2.0 and resource generation. Overall the provision of regional information relating to Wales and of Welsh-language material has remained remarkably static since the last General Election in 2005. It appears that only parties which regularly contest seats in Wales make regional provision and that Welsh-language provision is limited to those parties who have websites specifically orientated to Wales. The Welsh language does not appear to have been a priority in terms of online political communication for most of the parties campaigning in Wales during the General Election. Even on those sites making a bilingual provision, the quality, timeliness and extent of the Welsh-language experience varied considerably.
Is There a Relationship Between Optic Canal, Foramen Rotundum, and Vidian Canal?

Objectives:In this retrospective study, we investigated the relationship between paranasal sinus, optic canal, foramen rotundum, and vidian canal measurements. Methods:Computed tomographic (CT) images of 320 adult subjects and 640 sides (right and left) were used. Paranasal sinus dimensions, optic canal (OC), foramen rotundum (FR), vidian canal (VC), bilateral FR (FRFR), bilateral vidian canal (VCVC), VC-foramen rotundum (VCFR), and VC-optic canal (VCOC) distances were measured. Results:Right VCFR (6.06 mm), and right and left VCOC values (20.34 and 20.31 mm) of the males were significantly higher than those of the females (5.50, 18.91, and 18.80 mm, respectively). Foramen rotundum, OC, and VC values were positively correlated with each other. There was also positive correlation between FR width and maxillary sinus height. Increase of OC width was related to increase in FR width and area, VCVC distance; and decrease in maxillary sinus width. There was positive correlation between FRFR, VCVC, VCFR, and VCOC distance values. There was negative correlation between VC width and area; VCVC, VCFR, and VCOC distance; and maxillary sinus, ethmoid sinus, and sphenoid sinus measurement values. As these sinuses pneumatized more, VC width and area values decreased. Conclusion:As a conclusion, the paranasal sinus, OC, VC, and FR values showed relationship with each other. Before performing craniofacial and/or skull base surgeries, CT view should be taken to evaluate the localization and the course and dimensions of the OC and vidian nerve. It should be kept in mind that in the presence of more pneumatized paranasal sinuses in CT views, VC dimensions decreased.
A Strategic Outlook for Managing Information and Communication Technology : An Overview

Increasing investment of capital on Information and Communication Technology (ICT) within corporations has created expectations of optimized return from deployed ICT solutions. That is to say, organizations not only maximize the benefits of adopting ICTs but also avoid the many potential drawbacks and risks of rapid technological change. This paper is concerned with the value of strategic management of ICT solutions – with a focus on maximizing ICT benefits. It is based on a review of previous studies, technologists’ and strategists’ views and consideration of a number of cases studies within the Canterbury region of New Zealand. The review of case studies confirm that organizations do not vigorously follow strategic planning process. This could be due to perceived complexity and cost of strategic planning for SMEs.
Muscular and Gait Abnormalities in Persons With Early Onset Multiple Sclerosis

Background and Purpose: Muscular and gait abnormalities are common complaints among persons with multiple sclerosis, even in the early stages of the disease. Our aim was to evaluate peak isometric strength, major lower limb muscle fatigue, and spatiotemporal gait parameters in persons with a first neurological event suggestive of multiple sclerosis, defined as a clinically isolated syndrome (CIS). Methods: Fifty-two individuals (36 women, 16 men) with CIS, aged 35.2 (SD = 7.2) with an Expanded Disability Status Scale score of 1.7 (SD = 1.3), participated in the study. Peak isometric torque and fatigue index were measured at the knee and ankle bilaterally as well spatiotemporal parameters of gait. Twenty-eight age- and gender-matched healthy subjects served as controls. Results: The CIS group demonstrated increased muscle fatigue, and greater ankle muscle torque asymmetries compared with the control group. The overall fatigue index scores intensified on an average of 40% in the CIS group (27% vs 19% in controls). Participants in the CIS group walked with a larger step length difference, longer step time difference, wider base of support, and prolonged double support period compared with the control group. Positive correlations were identified between double support period and some muscle parameters. Discussion and Conclusion: At this early stage of clinically isolated syndrome, evidence of a reduction in lower limb motor performance can already be identified. The possibility of early identification and potential for developing an intervention program that may alter treatment outcome warrants further exploration.
Checking the secondary oxygen supply

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Agrobacterium pRi TL-DNA rolB and TR-DNA opine genes transferred to the spiny amaranth (Amaranthus spinosus L.), a nutraceutical crop.

Ajantaa Pal1,2, Swasti S. Swain1ψ, Arup K. Mukherjee2# and Pradeep K. Chand1∗ Plant Cell and Tissue Culture Facility, Post-Graduate Department of Botany, Utkal University, Bhubaneswar-751004, Orissa, India ψPresent address: Department of Botany, Ravenshaw University, Cuttack-753003, Orissa, India DNA Fingerprinting Laboratory, Division of Plant Biotechnology, Regional Plant Resource Centre, Bhubaneswar-751015, Orissa, India Present address: Division of Crop Protection, Central Institute for Cotton Research, Shankarnagar, Nagpur-440010, India
Carcinoma in situ of the testis.

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Natural History of Functional Dyspepsia: A 10-Year Population-Based Study

Background: Functional dyspepsia (FD) is a common disorder, but information on its natural history is limited. Aim: To study the natural history of FD as assessed by 2 criteria over a 10-year period. Method: A population-based study conducted by mailing a questionnaire to the same age- and gender-stratified random sample of the Icelandic population aged 18–75 in 1996 and again in 2006. FD was estimated by the Functional Dyspepsia Score List and by dyspepsia subgroups categorized into 4 groups: (1) frequent upper pain, (2) meal-related, (3) nausea or vomiting, and (4) combinations of these groups. Results: FD was diagnosed in 13.9% of the subjects in the 1996 sample (11.3% male, 15.8% female) and 16.7% in 2006 (12.3% male, 20.2% female) with a significant difference between males and females in 2006. Dyspepsia subgroup criteria showed a higher prevalence than conventional FD criteria. The proportion of FD subjects in one of the dyspepsia subgroups was low. There was a significant relationship between FD and heartburn and irritable bowel syndrome. A high proportion of subjects who seek medical care have FD. Conclusion: FD was stable over the 10-year period, but there was turnover in symptoms and increased intensity and frequency of gastrointestinal pain. Dyspepsia subgroup criteria showed a higher prevalence than FD, which was more common in young subjects and females. FD poses a heavy burden on the health care system.
Interstitial chemotherapy for malignant glioma: Future prospects in the era of multimodal therapy

The advent of interstitial chemotherapy has significantly increased therapeutic options for patients with malignant glioma. Interstitial chemotherapy can deliver high concentrations of chemotherapeutic agents, directly at the site of the brain tumor while bypassing systemic toxicities. Gliadel, a locally implanted polymer that releases the alkylating agent carmustine, given alone and in combination with various other antitumor and resistance modifying therapies, has significantly increased the median survival for patients with malignant glioma. Convection enhanced delivery, a technique used to directly infuse drugs into brain tissue, has shown promise for the delivery of immunotoxins, monoclonal antibodies, and chemotherapeutic agents. Preclinical studies include delivery of chemotherapeutic and immunomodulating agents by polymer and microchips. Interstitial chemotherapy was shown to maximize local efficacy and is an important strategy for the efficacy of any multimodal approach.
A new approach to binarizing neural networks

As deep neural networks grow larger, they suffer from a huge number of weights, and thus reducing the overhead of handling those weights becomes one of key challenges nowadays. This paper presents a new approach to binarizing neural networks, where the weights are pruned and forced to take degenerate binary values. Experimental results show that the proposed approach achieves significant reductions in computation and power consumption at the cost of a slight accuracy loss.
Poisson Hole Process: Theory and Applications to Wireless Networks

Interference field in wireless networks is often modeled by a homogeneous Poisson point process (PPP). While it is realistic in modeling the inherent node irregularity and provides meaningful first-order results, it falls short in modeling the effect of interference management techniques, which typically introduces some form of spatial interaction among active transmitters. In some applications, such as cognitive radio and device-to-device networks, this interaction may result in the formation of holes in an otherwise homogeneous interference field. The resulting interference field can be accurately modeled as a Poisson hole process (PHP). Despite the importance of the PHP in many applications, the exact characterization of interference experienced by a typical node in the PHP is not known. In this paper, we derive several tight upper and lower bounds on the Laplace transform of this interference. Numerical comparisons reveal that the new bounds outperform all known bounds and approximations, and are remarkably tight in all operational regimes of interest. The key in deriving these tight and yet simple bounds is to capture the local neighborhood around the typical node accurately while simplifying the far field to attain tractability. Ideas for tightening these bounds further by incorporating the effect of overlaps in the holes are also discussed. These results immediately lead to an accurate characterization of the coverage probability of the typical node in the PHP under Rayleigh fading.
Overview of Dynamic Strain Aging and Associated Phenomena in Fe–Mn–C Austenitic Steels

Synopsis : This paper presents an overview of the recent works on dynamic strain aging (DSA) of Fe-Mn-C austenitic steels including Hadfield and twinning-induced plasticity (TWIP) steels. First, a model of the DSA mechanism and its controlling factors are briefly explained in terms of Mn-C coupling and dislocation separation. Then, we introduce the effects of DSA on mechanical properties such as work hardening capabili-ty, uniform elongation, post-uniform elongation, and fatigue strength. Specifically, we note the pinning effect on extended dislocation for the work hardening, the Poretvin-Le Chatelier banding effect on damage evolution for the elongation, and the crack tip hardening/softening effect on crack resistance for the fatigue strength. We believe that this overview will help in designing advanced high-strength steels with superior ductility and fatigue resistance.