Miracle-dz/UniFAR-FTUs huggingface dataset:
Case Report: Identifying Wrist Fracture Patients with High Accuracy by Automatic Categorization of X-ray Reports

The authors performed this study to determine the accuracy of several text classification methods to categorize wrist x-ray reports. We randomly sampled 751 textual wrist x-ray reports. Two expert reviewers rated the presence (n = 301) or absence (n = 450) of an acute fracture of wrist. We developed two information retrieval (IR) text classification methods and a machine learning method using a support vector machine (TC-1). In cross-validation on the derivation set (n = 493), TC-1 outperformed the two IR based methods and six benchmark classifiers, including Naive Bayes and a Neural Network. In the validation set (n = 258), TC-1 demonstrated consistent performance with 93.8% accuracy; 95.5% sensitivity; 92.9% specificity; and 87.5% positive predictive value. TC-1 was easy to implement and superior in performance to the other classification methods.
Cirrus high-definition optical coherence tomography compared with Stratus optical coherence tomography in glaucoma diagnosis.

PURPOSE To compare the retinal nerve fiber layer (RNFL) evaluation using Cirrus optical coherence tomography (OCT) and Stratus OCT in glaucoma diagnosis. METHODS One hundred thirty normal and 86 patients with glaucoma were included in this prospective study. The signal strengths of the OCTs were evaluated. The sensitivities and specificities of global RNFL average thickness were compared in the four quadrants and in each clock hour sector. Receiver operating characteristic (ROC) curves, areas under the ROC (AUC), and the likelihood ratio (LR) were plotted for RNFL thickness. Agreement between the OCTs was calculated by using the Bland-Altman method and kappa (kappa) coefficient. RESULTS Twenty-three percent of all cases examined with Stratus OCT and 1.9% examined with Cirrus OCT had a signal strength below 6 (P = 0.01). In cases with signal strengths > or =6, the mean signal strength was higher with Cirrus OCT than with Stratus OCT (P = 0.01). The RNFL measurements by Cirrus were thicker than those of Stratus OCT (P < 0.05). The AUCs were 0.829 for Stratus and 0.837 for Cirrus OCT (P = 0.706) for global RNFL average. LRs were similar in both OCTs in global RNFL classification but varied in quadrants. The widths of the limits of agreement varied between 42.16 and 97.79 microm. There was almost perfect agreement (kappa = 0.82) in the average RNFL classification. CONCLUSIONS Cirrus OCT has better scan quality than Stratus OCT, especially in glaucomatous eyes. In cases with good-quality scans, the sensitivity and specificity, and AUCs were similar. The best agreement was in the global average RNFL classification. The widths of limits of agreements exceed the limits of resolution of the OCTs.
The in silico identification and characterization of a bread wheat/Triticum militinae introgression line

Summary The capacity of the bread wheat (Triticum aestivum) genome to tolerate introgression from related genomes can be exploited for wheat improvement. A resistance to powdery mildew expressed by a derivative of the cross‐bread wheat cv. Tähti × T. militinae (Tm) is known to be due to the incorporation of a Tm segment into the long arm of chromosome 4A. Here, a newly developed in silico method termed rearrangement identification and characterization (RICh) has been applied to characterize the introgression. A virtual gene order, assembled using the GenomeZipper approach, was obtained for the native copy of chromosome 4A; it incorporated 570 4A DArTseq markers to produce a zipper comprising 2132 loci. A comparison between the native and introgressed forms of the 4AL chromosome arm showed that the introgressed region is located at the distal part of the arm. The Tm segment, derived from chromosome 7G, harbours 131 homoeologs of the 357 genes present on the corresponding region of Chinese Spring 4AL. The estimated number of Tm genes transferred along with the disease resistance gene was 169. Characterizing the introgression's position, gene content and internal gene order should not only facilitate gene isolation, but may also be informative with respect to chromatin structure and behaviour studies.
The Teaching, Learning and Creativity (TLC) model for science

The Teaching, Learning and Creativity (TLC) model suggests a wide variety of activities in three different phases. In the Teaching Phase, the teacher will discuss, demonstrate key experiments and provide data for pupils to interpret. In the Learning Phase, pupils will analyse text, do a simple test and write an essay. In the Creativity Phase, pupils will plan their own experiments, carry them out and report. Pupils are also expected to write creatively. Interested readers are now invited to do action research to test this model.
Fast FEM/BEM simulation of SAW devices via asymptotic waveform evaluation

The finite element method/boundary element method (FEM/BEM) computation model applied to surface acoustic wave devices requires the solution of a large linear system for each frequency point. An asymptotic waveform evaluation technique is used to obtain an approximate solution of the linear system that is valid over a large frequency bandwidth. The approximate solution was shown to be very accurate and vastly reduces the computation time.
Modulation of Neuronal Signal Transduction and Memory Formation by Synaptic Zinc

The physiological role of synaptic zinc has remained largely enigmatic since its initial detection in hippocampal mossy fibers over 50 years ago. The past few years have witnessed a number of studies highlighting the ability of zinc ions to regulate ion channels and intracellular signaling pathways implicated in neuroplasticity, and others that shed some light on the elusive role of synaptic zinc in learning and memory. Recent behavioral studies using knock-out mice for the synapse-specific zinc transporter ZnT-3 indicate that vesicular zinc is required for the formation of memories dependent on the hippocampus and the amygdala, two brain centers that are prominently innervated by zinc-rich fibers. A common theme emerging from this research is the activity-dependent regulation of the Erk1/2 mitogen-activated-protein kinase pathway by synaptic zinc through diverse mechanisms in neurons. Here we discuss current knowledge on how synaptic zinc may play a role in cognition through its impact on neuronal signaling.
Urban and Rural—Population and Energy Consumption Dynamics in Local Authorities within England and Wales

The formulation of feasible and pragmatic policies that mitigate climate change would require a thorough understanding of the interconnectivity that exists between environment, energy, and the composition of our settlements both urban and rural. This study explores the patterns of energy consumption in England and Wales by investigating consumption behavior within domestic and transport sectors as a function of city characteristics, such as population, density, and density distribution for 346 Local Authority Units (LAU). Patterns observed linking energetic behavior of these LAUs to their respective population and area characteristics highlight some distinctly contrasting consumption behaviors within urban and rural zones. This provides an overview of the correlation between urban/rural status, population, and energy consumption and highlights points of interest for further research and policy intervention. The findings show that energy consumption across cities follows common power law scaling increasing sub-linearly with their population regardless of their urban/rural classification. However, when considering per capita and sector specific consumptions, decreasing per capita consumption patterns are observed for growing population densities within more uniformly populated urban LAUs. This is while rural and sparsely populated LAUs exhibit sharply different patterns for gas, electricity, and transport per capita consumption.
Content Mazes and Filled Pauses in Narrative Language Samples of Children with Specific Language Impairment

Linguistic nonfluencies known as mazes (filled pauses, repetitions, revisions, and abandoned utterances) have been used to draw inferences about processing difficulties associated with the production of language. In children with normal language development (NL), maze frequency in general increases with linguistic complexity, being greater in narrative than conversational contexts and in longer utterances. The same tendency has been found for children with specific language impairment (SLI). However, the frequency of mazes produced by children with NL and SLI has not been compared directly at equivalent utterance lengths in narration. This study compared the frequency of filled pauses and content mazes in narrative language samples of school-age children with SLI. The children with SLI used significantly more content mazes than the children with NL, but fewer filled pauses. Unlike content mazes, the frequency of filled pauses remained stable across samples of different utterance lengths among children with SLI. This indicates that filled pauses and content mazes have different origins and should not be analyzed or interpreted in the same way.
Microarray and qPCR Analyses of Wallerian Degeneration in Rat Sciatic Nerves

Wallerian degeneration occurs immediately following injury to mammal peripheral nerves. To better understand the molecular events occurring during Wallerian degeneration, a rat model of sciatic nerve transection was used to assess differentially expressed genes at 0.5, 1, 6, 12, 24 h, 4 days, 1, 2, 3, and 4 weeks post nerve injury (PNI). Hierarchical clustering, Euclidean distance matrix, and principal component analysis (PCA) collectively suggested three distinct phases within the post-injury period of 4 weeks. Gene ontology (GO) analysis suggested that phase I (0–6 h PNI), phase II (6–24 h PNI), and phase III (4 days to 4 weeks) were associated with acute response to injury, preformation of Wallerian degeneration, and complete execution of Wallerian degeneration, respectively. Critical signaling pathways and transcriptional factor networks responsible for the regulation of Wallerian degeneration were further identified and integrated using Kyoto Enrichment of Genes and Genomes (KEGG) pathway analysis and Ingenuity Pathway Analysis (IPA), respectively. Our results may help to elucidate some molecular mechanisms of gene regulation associated with Wallerian degeneration that occurs after traumatic injury to peripheral nerve axons in mammals.
Long-term Outcomes of Immediate Loading of Short Implants: A Controlled Retrospective Cohort Study.

PURPOSE Short implants (≤ 8.5 mm in length) have presented predictable outcomes. However, there is paucity in the long-term evaluation of immediate loading of short implants. The objective of this study was to assess the effect of the immediate loading of short implants on treatment outcomes. MATERIALS AND METHODS Patients having short implants inserted before December 2010 that were immediately loaded were selected. A database was then created to include the patient's data as well as implant- and prostheses-related outcomes. Long implants inserted at the same surgery and immediately loaded by the same prosthesis formed the control group. The proximal bone loss and the survival rates of implants and prostheses were assessed. RESULTS Forty-nine short and 38 long implants were placed in 30 patients. The mean follow-up time was 5.2 ± 0.8 years after loading, and three implants (two short and one long) failed. The differences in marginal bone loss and implant survival between short and long implants were not statistically significant. Three prosthetic complications occurred. Two prostheses failed, and the survival rate was 95.8%. CONCLUSION The immediate loading of short implants is not a risk factor for treatment success. This could be related to the good bone quality and the achievement of adequate primary stability.
Clonal B‐cell population in a reactive lymph node in acquired immunodeficiency syndrome

A 40‐year‐old female, HIV positive, stage C, since 4 years, complained of a right cervical lymph node swelling. Two years before, the patient had been diagnosed with follicular B‐cell non‐Hodgkin lymphoma (FL); she had been treated with four cycles of multiagent chemotherapy plus rituximab, the last cycle being administered 10 months before coming to our attention. An ultrasound (US) guided fine‐needle cytology (FNC) showed an atypical lymphoid cell proliferation. The phenotype evidenced by flow cytometry (FC) analysis was D5: 10%, CD19: 49%, CD23: 10%, FMC7: 0%, CD10: 40%, CD10/19: 40%, lambda light chain 40%, kappa light chain 0%. FDG‐positron emission tomography (PET/CT) scan showed positivity in the corresponding cervical area. Since low LDH values and a reduced lymph node size were observed, the lymph node was therefore excised; the histology revealed a reactive hyperplastic lymph node with florid follicular pattern. A subsequent PCR analysis, performed on DNA extracted from a whole histological section, did not evidence IgH rearrangement. The patient is currently undergoing strict clinical and instrumental follow‐up, including PET every 3 months; after 13 months, she is alive without recurrence of lymphoma. Clonal B‐cell populations in non‐lymphomatous processes have been described in mucosa‐associated lymphoid cell populations and reactive lymph nodes, and are considered non‐malignant, antigen driven, proliferations of B‐lymphocytes determined by an abnormal response to bacterial or viral antigen stimulation. The present case occurred in an HIV patient and was clinically complex because of the patient's history of FL. This experience suggests much attention in the evaluation of radiological, cytological, and FC data and in clinical correlation in patients suffering from autoimmune or immunodeficiency syndromes. Diagn. Cytopathol. 2009. © 2009 Wiley‐Liss, Inc.
Cellular Motor Protein KIF-4 Associates with Retroviral Gag

ABSTRACT Previously we demonstrated that murine retroviral Gag proteins associate with a cellular motor protein, KIF-4. Using the yeast two-hybrid assay, we also found an association of KIF-4 with Gag proteins of Mason-Pfizer monkey virus (MPMV), simian immunodeficiency virus (SIV), and human immunodeficiency virus type 1 (HIV-1). Studies performed with mammalian cell systems confirmed that the HIV-1 Gag protein associates with KIF-4. Soluble cytoplasmic proteins from cells infected with recombinant vaccinia virus expressing the entire Gag-Pol precursor protein of HIV-1 or transfected with HIV-1 molecular clone pNL4-3 were fractionated by sucrose gradient centrifugation and further separated by size-exclusion and anion-exchange chromatographies. KIF-4 and HIV-1 Gag cofractionated in both chromatographic separations. Immunoprecipitation assays have also verified the KIF-4–Gag association. KIF-4 binds mainly to the Gag precursor (Pr55 Gag) and a matrix-capsid processing intermediate (Pr42) but not to other processed Gag products. The binding of Gag is mediated by a domain of KIF-4 proximal to the C terminus. These results, and our previous studies, raise the possibility that KIF-4 may play an important role in retrovirus Gag protein transport.
The Cannabinoid Agonist Win55212 Reduces Brain Damage in an In Vivo Model of Hypoxic-Ischemic Encephalopathy in Newborn Rats

Neonatal hypoxic-ischemic encephalopathy (NHIE) is a devastating condition for which effective therapeutic treatments are still unavailable. Cannabinoids emerge as neuroprotective substances in adult animal studies; therefore, we aimed herein to test whether cannabinoids might reduce brain damage induced by hypoxia-ischemia (HI) in newborn rats. Thus, 7-d-old Wistar rats (P7) were exposed to 8% O2 for 120 min after left carotid artery ligature, then received s.c. vehicle (VEH) (HI+VEH), the cannabinoid agonist WIN55212 (WIN) (0.1 mg/kg), or WIN with the CB1 or CB2 receptor antagonist SR141617 (SR1) (3 mg/kg) or SR141588 (SR2) (2 mg/kg). Brain damage was assessed by magnetic resonance imaging (MRI) at 1, 3, and 7 d after the insult. At the end of the experiment, MRI findings were corroborated by histology (Nissl staining). HI+VEH showed an area of cytotoxic and vasogenic edema at 24 h after the insult, then evolving to necrosis. HI+WIN showed a similar damaged area at 24 h after the insult, but the final necrotic area was reduced by 66%. Coadministration of either SR1 or SR2 reversed the effects of WIN. In conclusion, likely by activating CB1 and CB2 receptors, WIN afforded robust neuroprotection in newborn rats after HI.
SE-ORAM: A Storage-Efficient Oblivious RAM for Privacy-Preserving Access to Cloud Storage

Oblivious RAM (ORAM) is a security-provable approach for protecting clients' access patterns to remote cloud storage. Recently, numerous ORAM constructions have been proposed to improve the communication efficiency of the ORAM model, but little attention has been paid to the storage efficiency. The state-of-the-art ORAM constructions have the storage overhead of O(N) or O(N log N) blocks at the server, when N data blocks are hosted. To fill the blank, this paper proposes a storage-efficient ORAM (SE-ORAM) construction with configurable security parameter λ and zero storage overhead at the server. Extensive analysis has also been conducted and the results show that, SE-ORAM achieves the configured level of security, introduces zero storage overhead to the storage server (i.e., the storage server only storages N data blocks), and incurs O(log N) blocks storage overhead at the client, as long as λ ≥ 2 and each node on the storage tree stores 4 log N or more data blocks.
Kant's Empirical Psychology

1. Introduction: the nature and possibility of empirical psychology 2. Kant's empirical account of human action 3. Kant's empirical account of human cognition 4. Kant's empirical account of moral motivation: respect for the moral law 5. Kant's empirical markers for moral responsibility 6. Defects of cognition: prejudice and mental disorder 7. Defects of volition: affects, passions, and weakness of will 8. Conclusion Appendix: charts and tables describing Kant's empirical psychology.
Familial multiple coagulation factor deficiencies: new biologic insight from rare genetic bleeding disorders

Summary. Combined deficiency of factor (F)V and FVIII (F5F8D) and combined deficiency of vitamin K‐dependent clotting factors (VKCFD) comprise the vast majority of reported cases of familial multiple coagulation factor deficiencies. Recently, significant progress has been made in understanding the molecular mechanisms underlying these disorders. F5F8D is caused by mutations in two different genes (LMAN1 and MCFD2) that encode components of a stable protein complex. This complex is localized to the secretory pathway of the cell and likely functions in transporting newly synthesized FV and FVIII, and perhaps other proteins, from the ER to the Golgi. VKCFD is either caused by mutations in the γ‐carboxylase gene or in a recently identified gene encoding the vitamin K epoxide reductase. These two proteins are essential components of the vitamin K dependent carboxylation reaction. Deficiency in either protein leads to under‐carboxylation and reduced activities of all the vitamin K‐dependent coagulation factors, as well as several other proteins. The multiple coagulation factor deficiencies provide a notable example of important basic biological insight gained through the study of rare human diseases.
NATURALLY OCCURRING MITOCHONDRIAL DNA HAPLOTYPES EXHIBIT METABOLIC DIFFERENCES: INSIGHT INTO FUNCTIONAL PROPERTIES OF MITOCHONDRIA

Linking the mitochondrial genotype and the organismal phenotype is of paramount importance in evolution of mitochondria. In this study, we determined the differences in catalytic properties of mitochondria dictated by divergences in the siII and siIII haplogroups of Drosophila simulans using introgressions of siII mtDNA type into the siIII nuclear background. We used a novel in situ method (permeabilized fibers) that allowed us to accurately measure the consumption of oxygen by mitochondria in constructed siII‐introgressed flies and in siIII‐control flies. Our results showed that the catalytic capacity of the electron transport system is not impaired by introgressions, suggesting that the functional properties of mitochondria are tightly related to the mtDNA haplogroup and not to the nuclear DNA or to the mito‐nuclear interactions. This is the first study, to our knowledge, that demonstrates a naturally occurring haplogroup can confer specific functional differences in aspects of mitochondrial metabolism. This study illustrates the importance of mtDNA changes on organelle evolution and highlights the potential bioenergetic and metabolic impacts that divergent mitochondrial haplogroups may have upon a wide variety of species including humans.
Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells

The effects exerted on the in vitro development of antigen-specific T cell lines and T cell clones by addition or neutralization of interleukin 12 (IL-12) in lymphocyte bulk culture were examined. T cell lines specific for Dermatophagoides pteronyssinus group I (Der p I) derived in the presence of IL-12 exhibited reduced ability to produce IL-4 and increased ability to produce interferon gamma (IFN-gamma), and developed into Der p I-specific CD4+ T cell clones showing a T helper type 0 (Th0)- or Th1-, instead of Th2-, like cytokine profile. In contrast, purified protein derivative (PPD)-specific T cell lines derived in the presence of anti-IL-12 antibody exhibited an increased ability to produce IL-4 and developed into PPD-specific CD4+ T cell clones showing a Th0-, instead of Th1-, like profile. The influence of IL-12 on the cytokine secretion profile of Der p I-specific T cell lines was not prevented by addition to lymphocyte bulk cultures of anti- IFN-gamma antibody, but could be at least partially inhibited by the removal from bulk cultures of CD16+ cells. Thus, IL-12 and CD16+ cells appear to have inhibitory effects on the development of IL-4-producing cells and to play an inductive role in promoting Th1-like responses.