Miracle-dz/UniFAR-FTUs huggingface dataset:
A phase II study (ARCHER 1042) to evaluate prophylactic treatment of dacomitinib-induced dermatologic and gastrointestinal adverse events in advanced non-small-cell lung cancer.

BACKGROUND ARCHER 1042, a randomized phase II trial, explored the impact of prophylactic treatment on select dermatologic adverse events of interest (SDAEI), diarrhea, and mucositis associated with dacomitinib, an oral irreversible pan-human epidermal growth factor receptor (HER) inhibitor, in development for advanced non-small-cell lung cancer (NSCLC). PATIENTS AND METHODS Patients with advanced NSCLC treated with dacomitinib were enrolled in two cohorts. Cohort I patients were randomized 1:1 to receive oral doxycycline or placebo (4 weeks). Cohort II patients received oral VSL#3 probiotic plus topical alclometasone. Primary end points for Cohorts I and II were incidence of all grade and grade ≥2 SDAEI in the first 8 weeks of treatment and quality of life (QoL) assessed by the Skindex-16 survey. Additional primary end points for Cohort II were incidence of all grade and grade ≥2 diarrhea and mucositis in the first 8 weeks of treatment; QoL regarding diarrhea and mucositis incidence was assessed by the modified-Oral Mucositis Daily Questionnaire. RESULTS Cohort I randomized 114 evaluable patients: 56 in the doxycycline arm, 58 in the placebo arm. Cohort II enrolled 59 evaluable patients. Doxycycline significantly reduced the incidence of grade ≥2 SDAEI by 50% (P = 0.016) compared with placebo. The incidence of all grade SDAEI was lower with doxycycline than with placebo but did not reach statistical significance. Doxycycline was associated with less deterioration in QoL compared with placebo. Alclometasone was associated with less deterioration in QoL compared with placebo but did not statistically significantly reduce the incidence of all grade or grade ≥2 SDAEI. VSL#3 did not reduce the incidence of all grade or grade ≥2 diarrhea and did not impact mucositis scores. CONCLUSIONS Doxycycline was effective as a prophylactic treatment for dacomitinib-induced grade ≥2 SDAEI. Both doxycycline and alclometasone reduced the negative impact in patient-reported dermatologic AEs. The probiotic was not effective for preventing diarrhea or mucositis.
PII: S0955-7997(99)00021-1

In this work, a boundary element model of an underwater landslide is developed. Careful gridding and time stepping techniques are demonstrated that produce highly accurate simulation results based on conservation of volume. A sensitivity analysis shows how to optimize simulation accuracy. The general techniques demonstrated herein are applicable to arbitrary moving submerged bodies. q 1999 Elsevier Science Ltd. All rights reserved.
How Do Older Chinese Women View Health and Cancer Screening? Results from Focus Groups and Implications for Interventions

Objective. To qualitatively assess Chinese American women's views of health and illness and the potential influences of culture and language on cancer screening behavior. Design. Data were generated by five focus groups, each consisting of 9–12 Chinese American women aged 50 and older. Participants responded to open‐ended questions assessing their perceptions of health and illness, knowledge about cancer, beliefs about and barriers to cancer screening, and screening and healthcare experiences in the USA. All conversations were tape‐recorded and analyzed in the context of PRECEDE framework concepts of predisposing, enabling, and reinforcing factors. Results. The 54 participants had a mean age of 65 years, with an average age of immigration to the USA at 51 and average length of residence in the USA of 15 years. Participants considered outdoor exercise in the morning for fresh air and a hot–cold balanced diet as important means to health. None mentioned the importance of regular medical checkups or cancer screening. When talking about cancer prevention, a sense of fatalism was evident, such as ‘no control of life and death’ and ‘what will happen will happen’. Lack of English capability was a major enabling barrier to healthcare. In addition, these women reported the need for help with transportation, especially for those living in suburban areas where public transportation is not readily available. Physician recommendation was identified as the most important reinforcing factor for cancer screening. Conclusion. Our results suggest traditional Chinese beliefs, such as those pertaining to fatalism, self‐care, and the hot and cold balance, influence the perceptions of older Chinese women regarding health, illness, and use of preventive healthcare. Interventions to improve cancer screening in this population should be tailored to the specific predisposing, enabling, and reinforcing factors of this population, including cultural views, language barriers, doctor–patient communication, and access to healthcare.
Spectral Gaps for Periodic Elliptic Operators with High Contrast: an Overview

We discuss the band-gap structure and the integrated density of states for periodic elliptic operators in the Hilbert space $L_2(\R^m)$, for $m \ge 2$. We specifically consider situations where high contrast in the coefficients leads to weak coupling between the period cells. Weak coupling of periodic systems frequently produces spectral gaps or spectral concentration. Our examples include Schr\"odinger operators, elliptic operators in divergence form, Laplace-Beltrami-operators, Schr\"odinger and Pauli operators with periodic magnetic fields. There are corresponding applications in heat and wave propagation, quantum mechanics, and photonic crystals.
An analysis of confrontation naming errors in senile dementia of the Alzheimer type.

Confrontation naming performance, as reflected by the Boston Naming Test, was examined in 25 healthy elderly adults and 49 elderly adults with very mild (n = 25) or mild senile dementia of the Alzheimer type (SDAT). Errors were classified within 17 different categories that differentially reflected perceptual, lexical, and semantic mechanisms. The results of these analyses suggest that, early in SDAT, there is a loss of lexical information and some loss in specific semantic attributes. As the disease progresses, however, there is increasing involvement of core semantic structures. These observations were supported by analyses of linguistically related errors, four-alternative forcedchoice recognition performance, and correlational analyses between performance on the Boston Naming Test and 12 standard psychometric tests.
In Search of Excellence: Perceived effects of special classes for gifted students in Ireland from the perspective of the students and their parents

This thesis focuses on high ability students and the effects of Saturday and summer courses on their academic and social development. These students who have been identified through assessment are in the top 5% of the population academically. After qualifying from the assessment they are invited to participate in courses run by the Irish Centre for Talented Youth (CTYI) at Dublin City University and other colleges around the country. This study looks at students who have participated on these programmes and their parents in relation to the impact of these courses on their academic and social development. Results show that participating students and their parents have a significantly higher level of academic satisfaction with classes at CTYI compared to school. Furthermore the parents and students perceive themselves to have a more positive attitude towards attending CTYI classes compared to school. Both parents and students within this study note a lack of academic challenge at school and believe that they receive little support from their classmates in relation to their ability. Parents tend to rank their children’s ability as much better than their peers in all academic subjects while most of the students rank themselves as much better in selected subjects. Students and parents within the study are mostly comfortable with their academic ability although this is seen to decline slightly as the child gets older. Most of the parents and the students who have attended special classes for high ability children are somewhat uncomfortable with the term gifted to describe their ability.
On Modelling in Memetics

The field of memetics is characterised and two types of memetic model analysed: the a priori model and the 'black-box' model. These are used to motivate a picture of scientific modelling, where by chains of models are built from abstract models at the 'top' down to data models derived from measurement. These models are linked to each other by validation (where the structure of a model comes from another) and verification (where the results of a model are checked against another). The role of formal models in clearly establishing these links is discussed. This picture is applied to the process of modelling in memetics. The paper argues that stronger selection are required to enable the field to evolve. In particular it argues that validation and verification constitute a minimum such set for memetic models.
Interviewing Strategies with Young People: The 'Secret Box', Stimulus Material and Task-based Activities

This paper reflects on the use of a range of interviewing strategies carried out with 13–14 year olds for a research project about young people's problems and coping strategies. The advantages and disadvantages of using both group and individual interviews with various task-based activities (grouping and ranking exercises, spider diagrams and charts) and stimulus material (problem pages, video clips and common phrases) are examined. The development and use of an innovative technique, the ‘secret box’, is also discussed. The mix of techniques alongside straightforward questioning was designed to offer variety to engage young people's interest, to account for their different preferences, to stimulate discussion about a potentially sensitive topic and to help to lessen the unequal power relationship between the adult researcher and the young participant. Copyright © 2002 John Wiley & Sons, Ltd.
Resting‐state functional connectivity of the human habenula in healthy individuals: Associations with subclinical depression

Introduction: The habenula (Hb) is postulated to play a critical role in reward and aversion processing across species, including humans, and has been increasingly implicated in depression. However, technical constraints have limited in vivo investigation of the human Hb, and its function remains poorly characterized. We sought to overcome these challenges by examining the whole‐brain resting‐state functional connectivity of the Hb and its possible relationship to depressive symptomatology using the high‐resolution WU‐Minn Human Connectome Project (HCP) dataset. Methods: Anatomical and resting‐state functional MRI data from 50 healthy subjects with low or high subclinical depression scores (n = 25 each) were analyzed. Using novel semi‐automated segmentation and optimization techniques, we generated individual‐specific Hb seeds and calculated whole‐brain functional connectivity for the entire cohort and the contrast of high vs. low depression groups. Results: In the entire cohort, the Hb exhibited significant connectivity with key brainstem structures (i.e., ventral tegmental area, substantia nigra, pons) as well as the anterior and posterior cingulate cortices, precuneus, thalamus, and sensorimotor cortex. Multiple regions showed differential Hb connectivity based on subclinical depression scores, including the amygdala, insula, and prefrontal, mid‐cingulate, and entorhinal cortices. Conclusions: Hb connectivity findings converged on areas associated with salience processing, sensorimotor systems, and the default mode network. We also detected substantial Hb‐brainstem connectivity, consistent with prior histological and animal research. High and low subclinical depression groups exhibited differences in Hb connectivity with multiple regions previously linked to depression, suggesting the relationship between these structures as a potential target for future research and treatment. Hum Brain Mapp 37:2369–2384, 2016. © 2016 Wiley Periodicals, Inc.
Late Holocene Climate Change And Human Behavioural Variability In The Coastal Wet-Dry Tropics Of Northern Australia: Evidence from a pilot study of oxygen isotopes in marine bivalve shells from archaeological sites

Abstract Previously it has been argued that midden analysis from three geographically distinct coastal regions of tropical northern Australia (Hope Inlet, Blyth River, Blue Mud Bay) demonstrates that changes through time in Aboriginal mollusc exploitation reflect broader coastal environmental transformations associated with late Holocene climatic variability (Bourke et al. 2007). It was suggested that, while a direct link between environmental change and significant cultural change in the archaeological record has yet to be demonstrated unambiguously, midden analysis has the potential to provide the as-yet missing link between changes in climate, environment and human responses over past millennia. We test this hypothesis with a preliminary sclerochronological analysis (i.e. of sequential stable isotopes of oxygen) of archaeological shell samples from all three regions. Our findings suggest the existence of variations in temperature and rainfall indicative of an increasing trend to aridity from 2000 to 500 cal. BP, consistent with previous palaeoenvironmental work across northern Australia.
Effects of Mountain Uplift and Climatic Oscillations on Phylogeography and Species Divergence in Four Endangered Notopterygium Herbs

Mountain uplift and climatic fluctuations are important driving forces that have affected the geographic distribution and population dynamics history of organisms. However, it is unclear how geological and climatic events might have affected the phylogeographic history and species divergence in high-alpine herbal plants. In this study, we analyzed the population demographic history and species differentiation of four endangered Notopterygium herbs on the high-altitude Qinghai–Tibetan Plateau (QTP) and adjacent areas. We combined phylogeographic analysis with species distribution modeling to detect the genetic variations in four Notopterygium species (N. incisum, N. franchetii, N. oviforme, and N. forrestii). In total, 559 individuals from 74 populations of the four species were analyzed based on three maternally inherited chloroplast fragments (matK, rbcL, and trnS-trnG) and one nuclear DNA region (internal transcribed spacer, ITS). Fifty-five chloroplast DNA (cpDNA) and 48 ITS haplotypes were identified in the four species. All of the cpDNA and ITS haplotypes were species-specific, except N. franchetii and N. oviforme shared one cpDNA haplotype, H32. Phylogenetic analysis suggested that all four species formed a monophyletic clade with high bootstrap support, where N. franchetii and N. oviforme were sisters. In addition, each Notopterygium species generated an individual clade that corresponded to their respective species in the ITS tree. Population dynamics analyses and species distribution modeling showed that the two widely distributed herbs N. incisum and N. franchetii exhibited obvious demographic expansions during the Pleistocene ice ages. Molecular dating suggested that the divergence of the four Notopterygium species occurred approximately between 3.6 and 1.2 Mya, and it was significantly associated with recent extensive uplifts of the QTP. Our results support the hypothesis that mountain uplift and Quaternary climatic oscillations profoundly shaped the population genetic divergence and demographic dynamics of Notopterygium species. The findings of this and previous studies provide important insights into the effects of QTP uplifts and climatic changes on phylogeography and species differentiation in high altitude mountainous areas. Our results may also facilitate the conservation of endangered herbaceous medicinal plants in the genus Notopterygium.
De la brecha digital a la brecha psico-digital: Mayores y redes sociales

En el presente estudio analizamos la evolucion del concepto de la brecha digital para los mayores desde la perspectiva del envejecimiento activo y en el contexto de la utilizacion de las redes sociales como instrumento de comunicacion. Consideramos que las variables socio-demograficas no tienen suficiente poder para explicar la utilizacion o no de las tecnologias de la comunicacion (TIC) por los mayores. Las variables de corte psicologico, como la edad cognitiva, la ansiedad tecnologica o el nivel de audacia complementan a las anteriores, e incluso, pueden ser mas explicativas del comportamiento del mayor con relacion a la utilizacion de redes sociales. Los resultados provenientes de una muestra de mayores, alumnos del Aula de Experiencia de una universidad, nos permiten confirmar que nuestras dudas acerca del estereotipo de los mayores respecto a la brecha digital son acertadas y que las variables psicologicas sirven, en mayor grado, para mostrar las diferencias significativas existentes entre usuarios y no usuarios de redes sociales en cuanto a la determinacion del perfil de los mismos. El usuario mayor de redes sociales se siente mas joven, experimenta un menor nivel de ansiedad tecnologica y es mas audaz. En general, las caracteristicas psicologicas ofrecen, por tanto, mayor poder discriminante que las socio-demograficas, por ello proponemos el concepto de brecha psico-digital.
Speaking Ourselves: The Intersections of Women Educators' Personal and Professional Lives

This paper presents findings from interviews conducted with 33 women educators working at varying levels of education and in diverse fields, and who varied in terms of age, ethnicity, race, family structure, geographic location, and sexual orientation.i Semi-structured interviews, building on variants of this question, Does who you are as person influence what you do as an educator and are there ways being an educator influences your life outside of work? , were conducted, tape recorded, and inductively analyzed. The themes uncovered suggest that women educators function as whole persons, aware of multiple intersections between their personal and professional lives. In a time of â€œteacher-proof,â€ scripted curricula, standardization, and other so-called reforms in the field of education, these findings remind us that teaching cannot be reduced to curricular guidelines and generic texts mandated from above. Rather, the diversity that teachers bring to the profession argues against a one-size fits-all model and for a contextualized pedagogy that cannot be limited to mere content dissemination.
Investigation of Limits to the Optical Performance of Asymmetric Fabry-Perot Electroabsorption Modulators

We have investigated the suitability of surface-normal asymmetric Fabry-Perot electroabsorption modulators for short-distance optical interconnections between silicon chips. These modulators should be made as small as possible to minimize device capacitance; however, size-dependent optical properties impose constraints on the dimensions. We have thus performed simulations that demonstrate how the optical performance of the modulators depends on both the spot size of the incident beam and the dimensions of the device. We also discuss the tolerance to nonidealities such as surface roughness and beam misalignment. The particular modulators considered here are structures based upon the quantum-confined Stark effect in Ge/GeSi quantum wells. We present device designs that have predicted extinction ratios greater than 7 dB and switching energies as low as 10 fF/bit, which suggests that these silicon-compatible devices can enable high interconnect bandwidths without the need for wavelength division multiplexing.
Leaf gas exchange characteristics of red raspberry germplasm in a hot environment

Net CO2 assimilation (A), evapotranspiration (ET), and stomatal conductance (gs) were determined in two experiments for 14 and 18 raspberry ( Rubus sp.) genotypes, respectively, grown in 4-L containers and exposed to 35 °C daytime temperatures 2 weeks and 4 weeks after placement in growth chambers. Measurements were taken on two successive leaves on the same primocane between the third and seventh node ( ≈75% to 85% of full leaf expansion). In Expt. 1, selections from Louisiana exhibited higher A (3.10- 5.73 μmol·m -2 ·s -1 ) than those from Oregon (0.50-2.65 μmol·m -2 ·s -1 ). In Expt. 2, the genotype × time interactions were nonsignificant, and time of measurement did not affect A or ET (P ≤ 0.05). Assimilation ranged from 2.08 to 6.84 μmol·m -2 ·s -1 and varied greatly among genotypes, indicating that diverse A levels exist at high temperatures in raspberry germplasm. NC 296, a selection of R. coreanus Miq. from China, and 'Dormanred', a southern-adapted raspberry cultivar with R. parvifolius Hemsl. as a parent, had the highest A rates. Evapotranspiration and gs did not differ among genotypes. Average gs for all genotypes declined from 234 mmol·m -2 ·s -1 in week 2 to 157 mmol·m -2 ·s -1 in week 4. Our findings, coupled with plant performance under hot conditions, can be used to identify potential parental raspberry germplasm for breeding southern-adapted cultivars. dure exists to identify those selections that have inherited heat tolerance or to determine which species have the most to offer a breed- ing program. Gas exchange characteristics of Rubus germplasm may indicate adaptation to hot conditions. Donnelly and Vidaver (1984) reported re- sults on a raspberry selection (BC 72-1-7, a cross of 'Haida' x 'Canby', later released as 'Algonquin') with the maximum rate of A between 6.3 and 9.5 μmol·m -2
Magnetosonoporation: Instant magnetic labeling of stem cells

The purpose of this study was to develop an instant MR cell labeling technique, called magnetosonoporation. First, a magnetosonoporation apparatus was successfully established for MR labeling of stem cells. Then, the safety of this new cell labeling approach was confirmed by evaluation of cell viability, proliferation, and differentiation of magnetosonoporation‐labeled and unlabeled C17.2 neural stem cells. Subsequently, the feasibility of using in vivo MRI to detect magnetosonoporation/Feridex‐labeled stem cells was validated in living animals and confirmed by histologic correlation. The magnetosonoporation technique is expected to be convenient, efficient, and safe for future clinical application of MRI‐guided cell therapies. Magn Reson Med 63:1437–1441, 2010. © 2010 Wiley‐Liss, Inc.
A Contradiction in Terms? Making Sense of Emotional Intelligence in a Construction Management Environment

Emotional intelligence (EI) has been hailed as being critical to individual performance within organizations. However, recent theoretical debates indicate that scholars need to apply a more differentiated lens when examining the utility of EI in a particular organizational context. In this study, we seek to contribute preliminary empirical evidence to this debate. Drawing upon an interpretivist approach and a narrative analysis, we examine how UK construction project managers make sense of EI, and how this shapes their receptiveness to the construct. Our data analysis suggests that there are enduring, albeit changing, characteristics of the industry and the sensemaking processes of project managers that renders the construct, at least for the time being, of limited utility. Thus, our analysis is a cautionary tale for those management scholars and practitioners who argue for the ‘trainability’ of EI.