Miracle-dz/UniFAR-FTUs huggingface dataset:
The Blue Straggler Population in the Globular Cluster M53 (NGC 5024): A Combined HST, LBT, and CFHT Study

We used a proper combination of high-resolution and wide-field multiwavelength observations collected at three different telescopes (HST, LBT, and CFHT) to probe the blue straggler star (BSS) population in the globular cluster M53. Almost 200 BSSs have been identified over the entire cluster extension. The radial distribution of these stars has been found to be bimodal (similar to that of several other clusters) with a prominent dip at ~60″ (~2rc) from the cluster center. This value turns out to be a factor of 2 smaller than the radius of avoidance (ravoid, the radius within which all the stars of ~1.2 M☉ have sunk to the core because of dynamical friction effects in a Hubble time). While in most of the clusters with a bimodal BSS radial distribution, ravoid has been found to be located in the region of the observed minimum, this is the second case (after NGC 6388) where this discrepancy is noted. This evidence suggests that in a few clusters the dynamical friction seems to be somehow less efficient than expected. We have also used this database to construct the radial star density profile of the cluster; this is the most extended and accurate radial profile ever published for this cluster, including detailed star counts in the very inner region. The star density profile is reproduced by a standard King Model with an extended core (~25″) and a modest value of the concentration parameter (c = 1.58). A deviation from the model is noted in the most external region of the cluster (at r > 6.5′ from the center). This feature needs to be further investigated in order to address the possible presence of a tidal tail in this cluster.
Linkage of Multiple Sclerosis and Guillain-Barre Syndrome: A Population-Based Survey in Isfahan, Iran

Background. Multiple Sclerosis (MS) and Guillain Barre Syndrome (GBS) are autoimmune demyelinating disorders of Central and Peripheral Nervous system, respectively. The coexistence of these two syndromes in an individual's life span is rare. Objectives. To inspect throughout Isfahan MS society (IMSS) records for MS cases who had history of documented GBS whether before the onset of MS or after it. Methods. This retrospective survey was carried out by analyzing the clinical records of 3,522 MS patients who were registered with IMSS, from April 2003 to July 2010. Eligible cases were requested to attend to IMSS for final clinical/paraclinical examinations. Results. Among 3,522 (2,716 women and 806 men) MS subjects, we could identify seven patients (six females and one male) with documented diagnosis of GBS. Six patients (five women and one man) had developed MS within 6.5 ± 7.0 (range: 1–16) years after being diagnosed with GBS and one (a woman) had developed GBS three years after the diagnosis of MS. Conclusion. It seems that the development of MS in individuals with history of GBS is more than a simple incidental event.
Detecting Uncertainty Cues in Hungarian Social Media Texts

In this paper, we aim at identifying uncertainty cues in Hungarian social media texts. We present our machine learning based uncertainty detector which is based on a rich features set including lexical, morphological, syntactic, semantic and discourse-based features, and we evaluate our system on a small set of manually annotated social media texts. We also carry out cross-domain and domain adaptation experiments using an annotated corpus of standard Hungarian texts and show that domain differences significantly affect machine learning. Furthermore, we argue that differences among uncertainty cue types may also affect the efficiency of uncertainty detection.
How Well Do Clinical Pain Assessment Tools Reflect Pain in Infants?

Background Pain in infancy is poorly understood, and medical staff often have difficulty assessing whether an infant is in pain. Current pain assessment tools rely on behavioural and physiological measures, such as change in facial expression, which may not accurately reflect pain experience. Our ability to measure cortical pain responses in young infants gives us the first opportunity to evaluate pain assessment tools with respect to the sensory input and establish whether the resultant pain scores reflect cortical pain processing. Methods and Findings Cortical haemodynamic activity was measured in infants, aged 25–43 wk postmenstrual, using near-infrared spectroscopy following a clinically required heel lance and compared to the magnitude of the premature infant pain profile (PIPP) score in the same infant to the same stimulus (n = 12, 33 test occasions). Overall, there was good correlation between the PIPP score and the level of cortical activity (regression coefficient = 0.72, 95% confidence interval [CI] limits 0.32–1.11, p = 0.001; correlation coefficient = 0.57). Of the different PIPP components, facial expression correlated best with cortical activity (regression coefficient = 1.26, 95% CI limits 0.84–1.67, p < 0.0001; correlation coefficient = 0.74) (n = 12, 33 test occasions). Cortical pain responses were still recorded in some infants who did not display a change in facial expression. Conclusions While painful stimulation generally evokes parallel cortical and behavioural responses in infants, pain may be processed at the cortical level without producing detectable behavioural changes. As a result, an infant with a low pain score based on behavioural assessment tools alone may not be pain free.
Laboratory Animal Models for Brucellosis Research

Brucellosis is a chronic infectious disease caused by Brucella spp. , a Gram-negative facultative intracellular pathogen that affects humans and animals, leading to significant impact on public health and animal industry. Human brucellosis is considered the most prevalent bacterial zoonosis in the world and is characterized by fever, weight loss, depression, hepato/splenomegaly, osteoarticular, and genital infections. Relevant aspects of Brucella pathogenesis have been intensively investigated in culture cells and animal models. The mouse is the animal model more commonly used to study chronic infection caused by Brucella. This model is most frequently used to investigate specific pathogenic factors of Brucella spp. , to characterize the host immune response, and to evaluate therapeutics and vaccines. Other animal species have been used as models for brucellosis including rats, guinea pigs, and monkeys. This paper discusses the murine and other laboratory animal models for human and animal brucellosis.
Network-based methods for outcome prediction in the "sample space"

In this thesis we present the novel semi-supervised network-based algorithm P-Net, which is able to rank and classify patients with respect to a specific phenotype or clinical outcome under study. The peculiar and innovative characteristic of this method is that it builds a network of samples/patients, where the nodes represent the samples and the edges are functional or genetic relationships between individuals (e.g. similarity of expression profiles), to predict the phenotype under study. In other words, it constructs the network in the "sample space" and not in the "biomarker space" (where nodes represent biomolecules (e.g. genes, proteins) and edges represent functional or genetic relationships between nodes), as usual in state-of-the-art methods. To assess the performances of P-Net, we apply it on three different publicly available datasets from patients afflicted with a specific type of tumor: pancreatic cancer, melanoma and ovarian cancer dataset, by using the data and following the experimental set-up proposed in two recently published papers [Barter et al., 2014, Winter et al., 2012]. We show that network-based methods in the "sample space" can achieve results competitive with classical supervised inductive systems. Moreover, the graph representation of the samples can be easily visualized through networks and can be used to gain visual clues about the relationships between samples, taking into account the phenotype associated or predicted for each sample. To our knowledge this is one of the first works that proposes graph-based algorithms working in the "sample space" of the biomolecular profiles of the patients to predict their phenotype or outcome, thus contributing to a novel research line in the framework of the Network Medicine.
Robust reconstruction on trees is determined by the second eigenvalue

Consider a Markov chain on an infinite tree T = (V,E) rooted at . In such a chain, once the initial root state ( ) is chosen, each vertex iteratively chooses its state from the one of its parent by an application of a Markov transition rule (and all such applications are independent). Let µj denote the resulting measure for ( ) = j. µj is defined on configurations = ( (x))x2V 2 A V , where A is some finite set. Let µ n denote the restriction of µ to the sigma-algebra generated by the variables (x) where x is at distance exactly n from . Letting n = maxi,j2A dTV (µ n ,µ n ), where dTV denotes total variation distance, we say that the reconstruction problem is solvable if liminfn! 1 n > 0. Reconstruction solvability roughly means that the n’th level of the tree contains a non-vanishing amount of information on the root of the tree, as n ! 1. In this paper we study the problem of robust reconstruction. Let be a non degenerate distribution on A and > 0. Let be chosen according to µ n and 0 be obtained from by letting for each node independently (v) = 0 (v) with probability 1 and 0 (v) to be an independent sample from otherwise. We denote by µ n [, ] the resulting measure on 0 . The measure µ n [, ] is a perturbation of the measure µ n . Letting n(, ) = maxi,j2A dTV (µ n [, ],µ n [, ]), we say that the reconstruction problem is -robust-solvable if liminfn! 1 n(, ) > 0 for all 0 1, where 2(M) is the second largest eigenvalue of M (in absolute value), then for all non-degenerate , the reconstruction problem is -robust-solvable. We prove a converse and show that the reconstruction problem is not -robust-solvable if B| 2(M)| 2 < 1. This proves a conjecture by the second author and Peres. We also consider other models of noise and general trees.
Specific Disruption of Hippocampal Mossy Fiber Synapses in a Mouse Model of Familial Alzheimer's Disease

The earliest stages of Alzheimer's disease (AD) are characterized by deficits in memory and cognition indicating hippocampal pathology. While it is now recognized that synapse dysfunction precedes the hallmark pathological findings of AD, it is unclear if specific hippocampal synapses are particularly vulnerable. Since the mossy fiber (MF) synapse between dentate gyrus (DG) and CA3 regions underlies critical functions disrupted in AD, we utilized serial block-face electron microscopy (SBEM) to analyze MF microcircuitry in a mouse model of familial Alzheimer's disease (FAD). FAD mutant MF terminal complexes were severely disrupted compared to control – they were smaller, contacted fewer postsynaptic spines and had greater numbers of presynaptic filopodial processes. Multi-headed CA3 dendritic spines in the FAD mutant condition were reduced in complexity and had significantly smaller sites of synaptic contact. Significantly, there was no change in the volume of classical dendritic spines at neighboring inputs to CA3 neurons suggesting input-specific defects in the early course of AD related pathology. These data indicate a specific vulnerability of the DG-CA3 network in AD pathogenesis and demonstrate the utility of SBEM to assess circuit specific alterations in mouse models of human disease.
Dopamine in Motor Cortex Is Necessary for Skill Learning and Synaptic Plasticity

Preliminary evidence indicates that dopamine given by mouth facilitates the learning of motor skills and improves the recovery of movement after stroke. The mechanism of these phenomena is unknown. Here, we describe a mechanism by demonstrating in rat that dopaminergic terminals and receptors in primary motor cortex (M1) enable motor skill learning and enhance M1 synaptic plasticity. Elimination of dopaminergic terminals in M1 specifically impaired motor skill acquisition, which was restored upon DA substitution. Execution of a previously acquired skill was unaffected. Reversible blockade of M1 D1 and D2 receptors temporarily impaired skill acquisition but not execution, and reduced long-term potentiation (LTP) within M1, a form of synaptic plasticity critically involved in skill learning. These findings identify a behavioral and functional role of dopaminergic signaling in M1. DA in M1 optimizes the learning of a novel motor skill.
The Effect of Lupinus albus on Growth Performance, Body Composition and Satiety Hormones of Male Pigs Immunized against Gonadotrophin Releasing Factor

Simple Summary Pigs immunized against gonadotrophin releasing factor (immunocastrates; IC males) have an increased feed intake, growth rate, back fat and fat deposition compared to entire males. A previous experiment found that Lupinus albus L. (albus lupins) has the potential to reduce feed intake and fat deposition in IC males. The current experiment aimed to develop a dietary management strategy using albus lupins for either 14 or 28 days pre-slaughter to reduce the increase in feed intake and subsequent increase in carcass fatness in IC males. Abstract Two hundred and ninety four pigs were used with the aim to develop a dietary management strategy using Lupinus albus L. (albus lupins) to reduce the increase in feed intake and subsequent increase in carcass fatness in pigs immunized against gonadotrophin releasing factor (immunocastrates; IC males) and entire male pigs in the late finishing stage. From day (d) 0 to 28, IC males fed the control diet grew faster (p = 0.009) than entire males fed the control diet but there was no difference in growth rate between sexes for pigs fed albus lupins for 14 days pre-slaughter (Albus 14) or pigs fed albus lupins for 28 days pre-slaughter (Albus 28). From d 15 to 28, IC males receiving the Albus 14 diet grew more slowly (p < 0.001) than entire males receiving the Albus 14 diet. From d 15 to 28 (p < 0.001), IC males fed the control diet ate more feed than entire males fed the control diet, although there was no difference between sexes in feed intake of the Albus 14 and Albus 28 diet. Immunocastrates had a lower backfat when fed either Albus 14 or Albus 28 compared to the control diet, although there was no difference between diets for entire males. There was also a trend for pigs on the Albus 14 and Albus 28 diets to have a higher lean deposition (p = 0.055) and a lower fat deposition (p = 0.056) compared to the pigs on the control diet. Pigs fed the Albus 28 diet had a lower plasma ghrelin concentration compared to pigs fed the Albus 14 or the control diet (p = 0.002). Pigs fed the Albus 28 diet had a higher peptide YY concentration than those fed the control or albus 14 diet (p = 0.004). The inclusion of albus lupins at 20% in the diets of IC male pigs for either 14 or 28 days pre-slaughter was successful in reducing feed intake, body fat and backfat to similar levels of entire males. However, the growth rate of the IC male pigs was impacted more than would be desirable.
Impostor phenomenon and motivation: women in higher education

ABSTRACT This article analyses the relationship between impostor phenomenon and motivation in academic women. These highly successful academics often express feelings of self-doubt, lack of belongingness, and incompetence, ideas echoed within motivation literature. This project establishes IP prevalence within 1,326 self-identified academic women and examines the relationship between IP and motivation (operationalized by measures from Expectancy-Value Theory, Attribution Theory, and Self-Determination Theory). Findings indicate elevated levels of IP amongst our female academic sample. Statistically significant relationships were observed between IP and measures of motivation, including negative relationships between IP and sense of relatedness, as well as IP and attributions of success and failure. Results also indicate a combination of feelings of competence and relatedness, attributions to luck, ability, ease, and effort, and both cost and utility values predict 57.6% of the variance in IP sum score. Implications for graduate and early career supports, as well as systemic and cultural changes are discussed.
Classification of wild tomatoes: a review

Wild tomatoes are native to western South America. The generic status of wild tomatoes within the Solanaceae has been controversial since the eighteen century. Linnaeus in 1753 placed tomatoes in Solanum while Miller, a contemporary ofLinnaeus, classified tomatoes in a new genus Lycopersicon. The majority of later botanists have followed Miller. Differing numbers of species and conflicting supraspecific classifications have been proposed, based on morphology or crossing studies. Two major crossability groups have been identified, one that includes mainly self-compatible species that easily cross with the cultivated tomato, and another that comprises self-incompatible species not easily cross with the cultivated tomato. Recent molecular investigations using appropriate outgroups have shown that tomatoes and potatoes are close related phylogenetically, and support the inclusion of tomatoes within Solanum, the classification advocated here. We discuss the conflicting goals of classifications based on predictivity versus stability, a continuing controversy in systematics.
Integrated Inquiry: Mystical Intuition and Research

The purpose of this paper is to initiate a broader dialogue on the use of integrated intelligence (or INI) in formal research. The application of INI in research is referred to as integrated inquiry. The idea of integrated intelligence, and its specific applications, can be viewed as genuine cognitive processes, or for the more skeptical, as provocations to inspire the researcher toward greater creativity. The first part of this paper briefly defines important terms and situates the idea of integrated intelligence within a historical and civilisational perspective. Finally, the most important section of this paper outlines specific and practical ways that INI can be used by the modern researcher. The five INI tools are the Intuitive Di- ary, Free-form Writing, Meditative States, The Feeling Sense, and Embracing Synchronicity. The essential argument of this paper is that integrated inquiry can greatly enhance research.
A multi-level correction scheme for eigenvalue problems

AbstractIn this paper, a new type of multi-level correction scheme is proposed forsolving eigenvalue problems by ﬁnite element method. With this new scheme,the accuracy of eigenpair approximations can be improved after each correc-tion step which only needs to solve a source problem on ﬁner ﬁnite elementspace and an eigenvalue problem on the coarsest ﬁnite element space. Thiscorrection scheme can improve the eﬃciency of solving eigenvalue problemsby ﬁnite element method.Keywords. Eigenvalue problem, multi-level correction scheme, ﬁnite ele-ment method, multi-space, multi-grid.AMS subject classiﬁcations. 65N30, 65B99, 65N25, 65L15 1 Introduction The purpose of this paper is to propose a new type of multi-level correction schemebased on ﬁnite element discretization to solve eigenvalue problems. The two-gridmethod for solving eigenvalue problems has been proposed and analyzed by Xu andZhou in [21]. The idea of the two-grid comes from [19, 20] for nonsymmetric orindeﬁnite problems and nonlinear elliptic equations. Since then, there have existedmany numerical methods for solving eigenvalue problems based on the idea of two-grid method ([1, 6, 17]).
Role of Sociability and Usability of Social Media on Consumer’s Behavioral Outcome; Mediation Role of Consumer Perceived Value

Since its commencement, online media platforms or networking sites has kept on encountering rapid growth. However, in literature, the marvel is still particularly in its early stage. Limited research studies in previous literature put spotlights on user’s behavioral outcome such as purchase intention resulted from web-based social media networking platforms. Such researchers either focus on the impact of social media operational components and characteristics of virtual group’s members on the behavioral outcome (consumer purchase intention). Therefore, present study presenting a robust insight through an integrated dynamic conceptual framework of the social media operational and psychological antecedents and their influence on consumers’ purchase intention for sustainable businesses through the mediation role of consumer perceived value. This study focuses on social media importance for sustainable growth in business by effective the application of social media as a strategic tool. The strategy utilized is quantitative and 300 participants participated. Results was conducted by Smart PLS. Partial Least Square- Structural Equation Modelling (PLS-SEM) is applied on the data. However, the result demonstrates that web-based social media engagement antecedents decidedly or positively impact on buyer’s buying expectation or behavioral outcome.
Soluble and Membranous Vascular Endothelial Growth Factor Receptor-2 in Pregnancies Complicated by Pre-Eclampsia

Purpose There is a paucity of information on the serum soluble vascular endothelial growth factor receptor-2 (sVEGFR-2) concentrations, membranous VEGFR-2 expression and the mechanism involved in their modulations during the clinical onset of pre-eclampsia. This cross-sectional study was conducted to evaluate the concentration of sVEGFR-2 in serum and to investigate the expression of membranous VEGFR-2 in placentae of pre-eclampsia group. Materials and Methods The serum levels of sVEGFR-2 (n = 120) and the expression of membranous VEGFR-2 in placentae (n = 100) were analysed at third trimester of pregnancy by enzyme linked immunosorbent assay (ELISA) and immunohistochemistry respectively. The diagnostic parameters of sensitivity, specificity and association of soluble and membranous VEGFR-2 in these patients were evaluated. Results The serum levels of sVEGFR-2 in pre-eclampsia patients were found to be significantly reduced (p = 0.01, p = 0.001) in early and late pre-eclamptic sub-groups as compared to their respective third trimester control sub-groups. Also, the receiver operating characteristic (ROC) curve analysis showed a cut-off value of 7350.4 pg/mL, higher sensitivity (76%) and specificity (76%) for sVEGFR-2 in late onset (> 34 weeks) pre-eclamptic group. Significant down-regulation of membranous VEGFR-2 immunoreactivity was observed in all the placental cells (p = 0.0001) at > 34 weeks preeclamptic group. Conclusion The reduced serum levels of soluble VEGFR-2 and the down-regulated expression of membranous VEGFR-2 in the study group denoted abnormality in VEGF mediated placental function in all placental cells and thus VEGFR-2 may be a key factor, intimately associated with pre-eclampsia. This study shows the clinical utility of soluble and membranous VEGFR-2 in pre-eclampsia patients.
The Competitive Potential of IT Applications - An Analytical-argumentative Evaluation

One of the prevailing views is that technology-based IT assets do not have the potential for sustainable competitive advantage because they are usually not rare and can be easily acquired by competitors. However, previous RBV-based research on the competitive potential of IT has paid inadequate attention to IT applications, which are a combination of application software and (digital) information content. Conducting an RBV-inspired analytical-argumentative evaluation, we challenge this view and argue that different types of IT applications as sub-group of technology-based IT assets differ in their potential to yield competitive parity, temporary and sustainable competitive advantage. More specifically, we show that out of nine types of IT applications, one has the potential to yield competitive parity only, three have the potential to yield temporary competitive advantage, and five actually have the potential to yield sustainable competitive advantage. Based on our theoretical analysis we suggest six propositions for future empirical research.