Miracle-dz/UniFAR-FTUs huggingface dataset:
Implications of Formal Alcohol Screening in Burn Patients

The purpose of this study was to screen burn patients for alcohol use disorders to identify those at increased risk for repeat injury and adverse effects of alcohol use. We examined associations of at-risk drinking and dependence symptoms as measured by a formal screening tool and blood alcohol concentration (BAC) to guide further screening, treatment, and research. We hypothesized that the majority of drinkers would not have symptoms of alcohol dependence, that BAC would be inadequate to screen for alcohol disorders, and that at-risk drinkers would be more likely to be unemployed and uninsured than healthy drinkers. Formal screening of English speakers, age 16 to 75, admitted to the burn service for over 24 hours was conducted for a 6-month period, using the Alcohol Use Disorders Identification Test. Of the 123 patients eligible for the study, 110 (89.4%) were approached for formal screening, four refused (3.6%), and 13 were missed (10.6%). BAC was obtained in 68 of 110 (61.8%); no patient who reported abstinence had a positive BAC. Of the 106 screened, 34.9% were nondrinkers, 11.3% drank daily or almost daily, and 28.3% binge drank at least monthly (>4 drinks per occasion for men, >3 for women). Of the patients who drank, only eight patients reported one or more sign of dependence in the last year (11.6%). For the group as a whole, 20.9% met Alcohol Use Disorders Identification Test criteria for at-risk drinking, with an average BAC of 39.8 mg/dl, (range 0–242 mg/dl). Using BAC of ≥80 mg/dl, only 5.6% of patients would have been identified as at-risk drinkers. Twenty-three percent of patients had no health insurance, 36% of whom were at-risk drinkers compared with 17.3% of insured patients (P < .05). For the group as a whole, 41.8% of patients were unemployed. At-risk drinking did not differ between employed and unemployed patients (24.6% vs 17.8%, P > .05). Among burn patients, formal alcohol screening identified that one in five patients is at risk for further problems from their drinking and that most at-risk drinkers are binge drinkers and do not show signs of dependency. Formal screening identified more at-risk drinkers than BAC. Implications of the screening findings are 1) because most burn patients who drink are binge but not dependent drinkers, alcohol withdrawal should be infrequent, and 2) animal models of alcohol use and burn injury should study acute intoxication and binge exposure. In addition, 3) we would expect burn patients to respond to brief interventions for alcohol use disorders similar to trauma and primary care patients.
Geographic exposure risk of variant Creutzfeldt‐Jakob disease in US blood donors: a risk‐ranking model to evaluate alternative donor‐deferral policies

Variant Creutzfeldt‐Jakob disease (vCJD) has been transmitted by blood transfusion (TTvCJD). The US Food and Drug Administration (FDA) recommends deferring blood donors who resided in or traveled to 30 European countries where they may have been exposed to bovine spongiform encephalopathy (BSE) through beef consumption. Those recommendations warrant re‐evaluation, because new cases of BSE and vCJD have markedly abated.
Epidemiology of Suicide by Burns in the Province of Isfahan, Iran

The aim of the study was to determine epidemiologic features and factors associated with suicidal behaviors by burns requiring hospitalization in the province of Isfahan, Iran. A prospective population-based study of all suicidal behaviors by burns requiring hospitalization was conducted in the province of Isfahan, Iran, from March 21, 2005 to March 20, 2006. Data were obtained from patients, family members, and/or friends through interviews during the course of hospitalization. A total of 89 patients ages 13 to 62 years with suicidal behaviors by burns were identified during the study period, representing an overall incidence rate of 2.9 per 100,000 persons-year (P-Y; 95% confidence interval 2.3–3.5 per 100,000 P-Y). Females (4.7 per 100,000 P-Y) had a higher rate of suicidal behavior by burns than males (1.2 per 100,000 P-Y; P < .001). The age-specific rate of suicidal behavior by burns peaked at age group 20 to 29 years (6.3 per 100,000 P-Y). Among the population aged 15 to 29 years, married women had a higher rate of suicidal behavior by burns (9.3 per 100,000 P-Y) than single women (6.6 per 100,000 P-Y). The highest rate of suicidal behavior by burns was found among the unemployed population (17.7 per 100,000 P-Y). The most frequent precipitating factor for suicidal behavior was a quarrel with a family member, relative, and/or friend (61.8%). Depression and anxiety disorders were the most frequent psychiatric comorbidities associated with suicidal behaviors. Mortality rate caused by suicidal behavior by burns was 1.4 per 100,000 P-Y. A high rate of suicidal behavior among young and mostly married women in the province of Isfahan is a tragedy and great concern. Social, cultural, and economical factors may contribute to suicidal behavior in Isfahan, and they need to be addressed through education, support, and commitment. Findings of this study can be used for implementation of a preventive program(s) to reduce the incidence of suicide among high risk groups.
Copy-Paste Detection in Spreadsheets

When a company is in need of a reporting tool, the most commonly made decision is to choose for Excel. In fact, over 90% of the world’s companies base their decisions on a report made using Excel. This shows that the number of spreadsheet designers, of end-user programmers, is large. It has been estimated to be 5 times as large as the number of software programmers in the traditional sense. This is one of the reasons spreadsheets are error-prone, possibly leading to erroneous decisions. One of the causes of problems within spreadsheets is the prevalence of copy-pasting. In this thesis we have studied this problem and we present an algorithm to detect data clones within spreadsheets: formulas whose values are copied in a different location. Aside from this algorithm, which we based on existing algorithms for code clone detection in software engineering, we present a classification scheme for the found data clones. We evaluated both the algorithm and the classification using the EUSES corpus, resulting in the conclusion that data clones in spreadsheet are as common as code clones in source code. We also show that we are able to detect these data clones with precision rates similar to those achieved by state-of-the-art code clone detection algorithm.
Reliability and Validity of the Dutch Version of the Behavioural Status Index: A Nurse-Rated Forensic Assessment Tool

The Behavioural Status Index (BEST-Index) has been introduced into Dutch forensic psychiatry to measure change in risk level of future violence. The BEST-Index is a structured observational measure that assesses aggressive behavior, degree of insight, social skills, self-care, and work and leisure skills during inpatient treatment. Thus far, limited information regarding the psychometric properties of the Dutch version of the BEST-Index is available. The present study examines the reliability and validity of the Dutch BEST-Index in a sample of 291 mentally disordered offenders admitted to a forensic psychiatric hospital. Interrater reliability was investigated in a sample of 182 raters. Findings show that the Dutch BEST-Index can be used reliably and is significantly associated with risk of future violence and institutional aggression. Furthermore, this study revealed a different and clearer factor structure compared with the original one. Further research is needed to examine how these derived factors predict future recidivism.
Lipid-dependent regulation of exocytosis in S. cerevisiae by OSBP homolog (Osh) 4

ABSTRACT Polarized exocytosis is an essential process in many organisms and cell types for correct cell division or functional specialization. Previous studies established that homologs of the oxysterol-binding protein (OSBP) in S. cerevisiae, which comprise the Osh protein family, are necessary for efficient polarized exocytosis by supporting a late post-Golgi step. We define this step as the docking of a specific sub-population of exocytic vesicles with the plasma membrane. In the absence of other Osh proteins, yeast Osh4p can support this process in a manner dependent upon two lipid ligands, PI4P and sterol. Osh6p, which binds PI4P and phosphatidylserine, is also sufficient to support polarized exocytosis, again in a lipid-dependent manner. These data suggest that Osh-mediated exocytosis depends upon lipid binding and exchange without a strict requirement for sterol. We propose a two-step mechanism for Osh protein-mediated regulation of polarized exocytosis by using Osh4p as a model. We describe a specific in vivo role for lipid binding by an OSBP-related protein (ORP) in the process of polarized exocytosis, guiding our understanding of where and how OSBP and ORPs may function in more complex organisms. Highlighted Article: This study describes a role for lipid ligand binding by a yeast ORP in exocytic vesicle docking, guiding our understanding of how ORPs may function in more complex organisms.
A Thousand Fly Genomes: An Expanded Drosophila Genome Nexus

The Drosophila Genome Nexus is a population genomic resource that provides D. melanogaster genomes from multiple sources. To facilitate comparisons across data sets, genomes are aligned using a common reference alignment pipeline which involves two rounds of mapping. Regions of residual heterozygosity, identity-by-descent, and recent population admixture are annotated to enable data filtering based on the user’s needs. Here, we present a significant expansion of the Drosophila Genome Nexus, which brings the current data object to a total of 1,122 wild-derived genomes. New additions include 306 previously unpublished genomes from inbred lines representing six population samples in Egypt, Ethiopia, France, and South Africa, along with another 193 genomes added from recently-published data sets. We also provide an aligned D. simulans genome to facilitate divergence comparisons. This improved resource will broaden the range of population genomic questions that can addressed from multi-population allele frequencies and haplotypes in this model species. The larger set of genomes will also enhance the discovery of functionally relevant natural variation that exists within and between populations.
Multi-playerPursuit-EvasionGameswithOneSuperior Evader ⋆

Inspired by the hunting and foraging behaviors of group predators, this paper addresses a class of multi-player pursuit-evasion games with one superior evader, who moves faster than the pursuers. We are concerned with the conditions under which the pursuers can capture the evader, involving the minimum number and initial spatial distribution required as well as the cooperative strategies of the pursuers. We present some necessary or sufficient conditions to regularize the encirclement formed by the pursuers to the evader. Then we provide a cooperative scheme for the pursuers to maintain and shrink the encirclement until the evader is captured. Finally, we give some examples to illustrate the theoretical results.
Fifty shades of Rokkan? Reconceiving local party system nationalisation in Belgium

This paper scrutinises local party system nationalisation, arguing for a more fine-grained approach beyond the default local–national dichotomy in order to acknowledge the shaded palette colouring the place-bound partisan canvas. Based on a typology of vertical decisional autonomy, the morphology of the local party system is firstly described as comprising national, pseudo-national, pseudo-local, and independent local lists. Secondly, this underpins a refined index applied to describe local party system nationalisation in the case of Belgium. Including the two most recent rounds of local elections, the paper accounts for variation in the index. Regression analysis shows that overall political ecology matters more than social morphology. More specifically, the number of inhabitants, metropolitan status, the relative vote share of national lists in antecedent
Finding an operating region for a bio-inspired robotic fish underwater vehicle in the Lighthill framework

Sir J. Lighthill mathematical slender body swimming model formulates the biological fish propulsion mechanism (undulation) in fluid environment. The present research has focused on the relevance of Lighthill (LH) based biomimetic robotic propulsion. A 2-joint, 3-link multibody vehicle model biologically inspired by a Body Caudal Fin (BCF) carangiform fish propulsion mechanism is designed. Different mathematical propulsive waveforms are proposed in LH frame-work to generate posterior body undulation. These functions are combined with inverse kinematics to generate various bio-inspired trajectories for the robotic fish vehicle motion. The robotic fish model (kinematics and dynamics) is integrated with the Lighthill (LH) mathematical model framework. Comparative studies are undertaken among a LH model and the proposed propulsive wave models. LH Cubic and NURB quadratic functions are found to be 16.32 % and 17.94 % efficient than a non-LH function respectively. Based on the simulation results of critical kinematic parameters TBF and Propulsive wavelength, an operating region is established to facilitate the open-loop (manual) control experiments.
Surface expression of NMDA receptor changes during memory consolidation in the crab Neohelice granulata

The aim of the present study was to analyze the surface expression of the NMDA-like receptors during the consolidation of contextual learning in the crab Neohelice granulata. Memory storage is based on alterations in the strength of synaptic connections between neurons. The glutamatergic synapses undergo various forms of N-methyl-D aspartate receptor (NMDAR)-dependent changes in strength, a process that affects the abundance of other receptors at the synapse and underlies some forms of learning and memory. Here we propose a direct regulation of the NMDAR. Changes in NMDAR's functionality might be induced by the modification of the subunit's expression or cellular trafficking. This trafficking does not only include NMDAR's movement between synaptic and extra-synaptic localizations but also the cycling between intracellular compartments and the plasma membrane, a process called surface expression. Consolidation of contextual learning affects the surface expression of the receptor without affecting its general expression. The surface expression of the GluN1 subunit of the NMDAR is down-regulated immediately after training, up-regulated 3 h after training and returns to naïve and control levels 24 h after training. The changes in NMDAR surface expression observed in the central brain are not seen in the thoracic ganglion. A similar increment in surface expression of GluN1 in the central brain is observed 3 h after administration of the competitive GABAA receptor antagonist, bicuculline. These consolidation changes are part of a plasticity event that first, during the down-regulation, stabilizes the trace and later, at 3-h post-training, changes the threshold for synapse activation.
Quantifying Collagen Type in Mature Burn Scars: A Novel Approach Using Histology and Digital Image Analysis

Using Herovici staining and digital image analysis, we have studied the collagen subtype and fiber orientation in mature burn scars. These techniques have shown mature burn scars to have increased type I/type III collagen ratios compared with normal skin. Additionally, the collagen orientation of burn scars has been shown to be thickened, tightly packed, and lacking the “basket weave” appearance of normal skin specimens. These techniques allow the differentiation of type I collagen from type III collagen, the assessment of collagen orientation, and the analysis of scar architecture in terms of epidermis and papillary/reticular dermis contribution. These findings are important clinically because collagen subtype and fiber orientation may predict future scar activity. Any attempt to modify the scarring process can be directly measured and compared using this easily reproducible technique.
Versatile Antagonistic Activities of Soil-Borne Bacillus spp. and Pseudomonas spp. against Phytophthora infestans and Other Potato Pathogens

The world potato is facing major economic losses due to disease pressure and environmental concerns regarding pesticides use. This work aims at addressing these two issues by isolating indigenous bacteria that can be integrated into pest management strategies. More than 2,800 strains of Bacillus-like and Pseudomonas-like were isolated from several soils and substrates associated with potato agro-systems in Belgium. Screenings for antagonistic activities against the potato pathogens Alternaria solani, Fusarium solani (BCCM-MUCL 5492), Pectobacterium carotovorum (ATCC 15713), Phytophthora infestans (CRA-W10022) and Rhizoctonia solani (BCCM-MUCL 51929) were performed, allowing the selection of 52 Bacillus spp. and eight Pseudomonas spp. displaying growth inhibition of at least 50% under in vitro conditions, particularly against P. infestans. All 60 bacterial isolates were identified based on 16S rRNA gene sequencing and further characterized for the production of potential bio-active secondary metabolites. The antagonistic activities displayed by the selected strains indicated that versatile metabolites can be produced by the strains. For instance, the detection of genes involved bacilysin biosynthesis was correlated with the strong antagonism of Bacillus pumilus strains toward P. infestans, whereas the production of both bio-surfactants and siderophores might explain the high antagonistic activities against late blight. Greenhouse assays with potato plants were performed with the most effective strains (seven Bacillus spp. and four Pseudomonas spp.) in order to evaluate their in vivo antagonistic effect against P. infestans. Based on these results, four strains (Bacillus amyloliquefaciens 17A-B3, Bacillus subtilis 30B-B6, Pseudomonas brenneri 43R-P1 and Pseudomonas protegens 44R-P8) were retained for further evaluation of their protection index against P. infestans in a pilot field trial. Interestingly, B. subtilis 30B-B6 was shown to significantly decrease late blight severity throughout the crop season. Overall, this study showed that antagonistic indigenous soil bacteria can offer an alternative to the indiscriminate use of pesticide in potato agro-systems.
Improved Utilization of Added B in 9Cr Heat-Resistant Steels Containing W

For the construction of ultra super critical (USC) power plant, 9Cr-3W base ferritic heat-resistant steels with relatively high B and no N have been investigated. Authors have been revealed in the previous report that the addition of 139ppm B significantly improves creep strength of the steels, whereas most of added B forms unidentified borides, which are deemed almost ineffective to creep strength. The effect of improved heat treatment on creep strength and distribution of B in precipitates is investigated to effectively utilize and decrease added B. As a result of the analysis of the extracted residue and characterization of precipitates using field emission Auger electron spectroscopy (FE-AES), most of added B still forms borides in the 92ppm B added steel. These composites are almost dissolved and the B content in M 23 C 6 carbides is significantly increased by normalizing at 1423K. It is also found by FE-AES analysis that B content in M 23 C 6 carbides near prior-austenite grain boundaries is relatively higher than that inside grains. Creep strength at 923K for the 92ppm B added steel normalized at 1423K is not improved at short times, but it is remarkably improved to almost the same level as the 139ppm B added steel at long times. This excellent creep strength is achieved resulting in improving microstructural stability through the effective utilization of added B by high-temperature normalizing.
Shredded Maize Stems as an Alternative Substrate Medium

Abstract The interest in the use of mixtures of inorganic and organic materials as substrate media in soilless culture in greenhouses is increasing in parts of the world where the mixtures have not been used in common practice. In this study, tomato (Lycopersicum esculentum Mill.), cv. Belladona, plants were grown over a five-month period in a closed soilless culture system on seven different substrates (perlite or pumice and their mixtures with 25% or 50% shredded maize stems) and in Nutrient Film Technique (NFT), in an unheated glasshouse. Substrate affected some characteristics of plant development and fruit yield. Plants grown on NFT were taller and had more leaves than did plants grown in perlite. Stem thickness differed according to substrate and time of measurement at 0.15, 1 and 2 m above the substrate surface. The total number of flowers and fruit produced varied with time and substrate, but there were no differences at the end of the experiment. Increased electri cal conductivity (EC) of the nutrient solution resulted in reduced numbers of flowers. The addition of shredded maize stems to mixes resulted in a higher yield, indicating there are beneficial effects of adding organic substances to inorganic substrates. Treatments did not affect occurrence of gray mold (Botrytis cinerea Pers. ex Fr.) or blossom-end rot on fruit. The results indicate that addition of shredded maize stems in perlite and pumice could improve their properties over inorganic substrates alone, and lead to improved plant development and yield for greenhouse cultured tomato.
Development of a Home Health-Based Palliative Care Program for Patients With Heart Failure

Heart failure is a significant burden to the healthcare system. Approximately 5.7 million adults in the United States were diagnosed with heart failure between 2009 and 2012 (Mozaffarian et al., 2016). The American Heart Association projects that direct costs for heart failure may be as high as $77.7 billion by 2030 (Heidenreich et al., 2011). Technological and pharmaceutical advancements have delayed the progression of the disease; however, it is predicted that close to half of individuals with heart failure will die within 5 years of the initial diagnosis (Braun et al., 2016; McIlvennan & Allen, 2016). Current research suggests that the utilization of palliative care and an interdisciplinary team approach to the care of patients with heart failure improves the quality of life and decreases utilization of healthcare resources at the end of life (Evangelista et al., 2014a). This performance improvement project examined the knowledge of a home healthcare interdisciplinary team's knowledge about palliative care in patients with heart failure, the 30-day readmission rate for patients enrolled in a home-based palliative care program, and documentation of advanced directives in a home healthcare organization.
Ultrafiltration for congestive heart failure: the past and the present

Purpose of review To provide an overview on the most recent evidence for the use of extracorporeal and peritoneal ultrafiltration in heart failure, focusing on the major publications from the last few years. Recent findings There have been several studies investigating the possible use of extracorporeal and peritoneal ultrafiltration in the management of acute and chronic heart failure. These trials have investigated the potential benefits and advantages of ultrafiltration over conventional medical therapy, in terms of clinical outcomes. Summary Although ultrafiltration remains an extremely appealing therapeutic option for patients with heart failure and congestion, with several theoretical beneficial effects, some of the most recent studies have reported inconsistent findings. Differences in the selection of the study population, heterogeneity of the indications for use of ultrafiltration, variation in the ultrafiltration protocols, and high variability in the pharmacologic therapy used for the control group could explain some of these conflicting findings.