Miracle-dz/UniFAR-FTUs huggingface dataset:
Plant Defensins NaD1 and NaD2 Induce Different Stress Response Pathways in Fungi

Nicotiana alata defensins 1 and 2 (NaD1 and NaD2) are plant defensins from the ornamental tobacco that have antifungal activity against a variety of fungal pathogens. Some plant defensins interact with fungal cell wall O-glycosylated proteins. Therefore, we investigated if this was the case for NaD1 and NaD2, by assessing the sensitivity of the three Aspergillus nidulans (An) O-mannosyltransferase (pmt) knockout (KO) mutants (An∆pmtA, An∆pmtB, and An∆pmtC). An∆pmtA was resistant to both defensins, while An∆pmtC was resistant to NaD2 only, suggesting NaD1 and NaD2 are unlikely to have a general interaction with O-linked side chains. Further evidence of this difference in the antifungal mechanism was provided by the dissimilarity of the NaD1 and NaD2 sensitivities of the Fusarium oxysporum f. sp. lycopersici (Fol) signalling knockout mutants from the cell wall integrity (CWI) and high osmolarity glycerol (HOG) mitogen-activated protein kinase (MAPK) pathways. HOG pathway mutants were sensitive to both NaD1 and NaD2, while CWI pathway mutants only displayed sensitivity to NaD2.
Vagal tone, development, and Gray's motivational theory: Toward an integrated model of autonomic nervous system functioning in psychopathology

In the last decade, cardiac vagal tone has emerged as a psychophysiological marker of many aspects of behavioral functioning in both children and adults. Research efforts during this time have produced an extensive list of vagal tone correlates that includes temperamental variables as well as both anxious/internalizing and disruptive/externalizing behaviors. This potentially confusing state of affairs is compounded by developmental shifts in vagal tone–behavior relations that to date have not been elucidated. In this paper, the vagal tone literature is reviewed, and discrepancies, including the lack of specificity of vagal tone as a psychophysiological marker, are clarified. Such clarification requires that we (a) view vagal tone–behavior relations in developmental context, (b) juxtapose vagal tone–behavior relations in typical and atypical samples, and (c) consider the parasympathetic underpinnings of vagal tone as but one component in a broader model of autonomic nervous system functioning. Such a model is provided by combining Gray's motivational theory with Porges's polyvagal theory. Together these models account for behavioral and emotional differences in a diverse range of psychological disorders that are not differentiated by either model alone. Moreover, use of the integrated model offers a theory-driven approach to the study of autonomic nervous system–behavior relations.
Asymptotic information leakage under one-try attacks†

We study the asymptotic behaviour of (a) information leakage and (b) adversary's error probability in information hiding systems modelled as noisy channels. Specifically, we assume the attacker can make a single guess after observing n independent executions of the system, throughout which the secret information is kept fixed. We show that the asymptotic behaviour of quantities (a) and (b) can be determined in a simple way from the channel matrix. Moreover, simple and tight bounds on them as functions of n show that the convergence is exponential. We also discuss feasible methods to evaluate the rate of convergence. Our results cover both the Bayesian case, where an a priori probability distribution on the secrets is assumed known to the attacker, and the maximum-likelihood case, where the attacker does not know such distribution. In the Bayesian case, we identify the distributions that maximize leakage. We consider both the min-entropy setting studied by Smith and the additive form recently proposed by Braun et al. and show the two forms do agree asymptotically. Next, we extend these results to a more sophisticated eavesdropping scenario, where the attacker can perform a (noisy) observation at each state of the computation and the systems are modelled as hidden Markov models.
Predicting the Impact of Intervention Strategies for Sleeping Sickness in Two High-Endemicity Health Zones of the Democratic Republic of Congo

Two goals have been set for Gambian human African trypanosomiasis (HAT), the first is to achieve elimination as a public health problem in 90% of foci by 2020, and the second is to achieve zero transmission globally by 2030. It remains unclear if certain HAT hotspots could achieve elimination as a public health problem by 2020 and, of greater concern, it appears that current interventions to control HAT in these areas may not be sufficient to achieve zero transmission by 2030. A mathematical model of disease dynamics was used to assess the potential impact of changing the intervention strategy in two high-endemicity health zones of Kwilu province, Democratic Republic of Congo. Six key strategies and twelve variations were considered which covered a range of recruitment strategies for screening and vector control. It was found that effectiveness of HAT screening could be improved by increasing effort to recruit high-risk groups for screening. Furthermore, seven proposed strategies which included vector control were predicted to be sufficient to achieve an incidence of less than 1 reported case per 10,000 people by 2020 in the study region. All vector control strategies simulated reduced transmission enough to meet the 2030 goal, even if vector control was only moderately effective (60% tsetse population reduction). At this level of control the full elimination threshold was expected to be met within six years following the start of the change in strategy and over 6000 additional cases would be averted between 2017 and 2030 compared to current screening alone. It is recommended that a two-pronged strategy including both enhanced active screening and tsetse control is implemented in this region and in other persistent HAT foci to ensure the success of the control programme and meet the 2030 elimination goal for HAT.
SapC-DOPS nanovesicles: a novel targeted agent for the imaging and treatment of glioblastoma

Glioblastoma multiforme (GBM) is the most common malignant primary brain tumor. Classified by the World Health Organization (WHO) as grade IV astrocytoma, GBMs are extremely aggressive, almost always recur, and despite our best efforts, remain incurable. This review describes the traditional treatment approaches that led to moderate successes in GBM patients, discusses standard imaging modalities, and presents data supporting the use of SapC-DOPS, a novel proteoliposomal formulation with tumoricidal activity, as a promising diagnostic imaging tool and an innovative anti-cancer agent against GBM.
IT and business process performance management: Case study of ITIL implementation in finance service industry

Although information technology (IT) is taking significant role in businesses with its innovating and supporting potential, it seems that it is least understood company asset. Successful organizations manage IT function in much the same way that they manage their other strategic functions and processes. This in particular means that they understand, manage and systematically measure the quality of IT performance. They are doing so by engaging in IT governance and IT audit activities. In recent years there are number of world-wide used standards and best practices in IT process management area such as CobiT and ITIL, which helps management to measure the IT performances. In this paper we present the case study of managing IT services in finance industry by implementing suggestions which arises from ITIL methodology. After brief explanation of key terms, the methodology of complex ITIL implementation project is given and key performance indicators for major IT related business processes stressed.
Ecological conservation, ecotourism, and sustainable management: the case of Penang National Park.

Penang National Park (PNP), as Malaysia’s smallest national park, is one of the few naturally forested areas left on Penang Island, in Peninsular Malaysia. The main objective was to analyse users’ preferences and willingness to pay to enhance improved management of PNP for the dual aim of conservation and recreation. Structural equation modelling (SEM) was used to analyse the formation of attitudes towards different aspects of PNP. Results showed that implementing enforcements with rules and regulations and imposing permits and charges on certain activities were the most influential variables of PNPs’ perceptions. The results of a random parameter logit model (RPL) demonstrated that visitors placed the highest value on having adequate information about PNP, and the second-highest value on improvements in the park’s ecological management. The welfare measure for improvement in management of PNP against status quo is estimated at about MYR 9. Results also showed that demand for better conservation and management of PNP is relatively price-inelastic. Simulations of the results showed, under a MYR10 admission fee, that improvement in management would have 96% of market share compared with status quo. This study concluded that visitor entrance fees can and ought to be introduced as a means of financing conservation initiatives and possibly preventing congestion.
Electronic brachytherapy as adjuvant therapy for early stage breast cancer: a retrospective analysis

Purpose: This multicenter, retrospective study evaluated treatment and clinical outcomes of patients with early stage breast cancer who received adjuvant high-dose rate (HDR) electronic brachytherapy (EBT) treatment post-lumpectomy using the Axxent® EBT system. Dosimetric data from the EBT treatment plans were compared with those based on iridium-192 HDR brachytherapy. Material and methods: Medical records of 63 patients with early stage breast cancer (Tis, T1a, T1b, T1c, and T2) who were treated post-lumpectomy with EBT alone or in combination with external beam radiation therapy were reviewed. The prescribed EBT dose was 34 Gy (10 fractions over 5 days, 3.4 Gy each) to 1 cm from the balloon surface. Dosimetry data from 12 patients were compared with these of treatment plans using an iridium-192 source prepared for the same 12 patients. Results: The majority of patients (90.5%) were older than 50 years and had one or more risk factors for breast cancer (80.6%). Tumor sizes were 0.1 cm to 3.5 cm (mean 1.3 cm). Median follow-up was 7 months (1 to 18 months) post-EBT. Balloon applicators were implanted 0 to 85 days (mean 13.4 days) post-lumpectomy/re-excision. The most common adverse events were erythema, rash dermatitis, and pain or breast tenderness. No recurrences were reported. Dosimetric analyses demonstrated comparable target coverage, increased high-dose regions, and a significantly reduced dose to the ipsilateral breast and lungs as well as the heart with EBT as compared with the iridium-192 treatment plans. Conclusion: This retrospective, multicenter study showed that postsurgical adjuvant radiation therapy for early stage breast cancer can be administered using the EBT system with similar toxicity outcomes to those reported with iridium-192 brachytherapy. EBT offers a convenient, portable, nonisotope alternative to HDR brachytherapy using iridium-192.
Comparing the Responsiveness over Time of Two Tactile Gnosis Tests: Two-Point Discrimination and the STI-Test

The purpose of this study was to investigate the responsiveness over time of a new instrument for the assessment of tactile gnosis after nerve repair to the hand - the shape texture identification (STI) test and to compare this to an existing tactile gnosis test - the two-point discrimination test (2PD). In order to assess the instruments ability to detect clinical change over time a cohort of 32 patients with 37 complete or partial median and/or ulnar nerve repair or double digital nerve repairs were assessed on three occasions over a six months period. Only patients with a touch detection threshold of 2g (Semmes-Weinstein Monofilament 4.31) or less, indicating presence of some protective sensibility, were included in the study. All patients received the same information and were given a standard sensory re-education programme after the initial assessment. The results from the STI test were analysed longitudinally with the Wilcoxon signed rank test and Standard Response Mean (SRM) was used to estimate the responsiveness and size of change over time. The results were compared to results from the two-point discrimination test. Between the first and second follow-up the STI-test detected improvements which were statistically significant (p=0.001). An improvement was also noted between the second and third test occasion, however this did not reach statistical significance. Results from the two-point discrimination test showed a flooring effect and change was only detected in the partial nerve repairs, between the first and last assessment. We conclude that the STI test is sensitive to change and should be used as an alternative to or at least complement the 2PD test when evaluating tactile gnosis after nerve repair.
RANK- and c-Met-mediated signal network promotes prostate cancer metastatic colonization

Prostate cancer (PCa) metastasis to bone is lethal and there is no adequate animal model for studying the mechanisms underlying the metastatic process. Here, we report that receptor activator of NF-κB ligand (RANKL) expressed by PCa cells consistently induced colonization or metastasis to bone in animal models. RANK-mediated signaling established a premetastatic niche through a feed-forward loop, involving the induction of RANKL and c-Met, but repression of androgen receptor (AR) expression and AR signaling pathways. Site-directed mutagenesis and transcription factor (TF) deletion/interference assays identified common TF complexes, c-Myc/Max, and AP4 as critical regulatory nodes. RANKL–RANK signaling activated a number of master regulator TFs that control the epithelial-to-mesenchymal transition (Twist1, Slug, Zeb1, and Zeb2), stem cell properties (Sox2, Myc, Oct3/4, and Nanog), neuroendocrine differentiation (Sox9, HIF1α, and FoxA2), and osteomimicry (c-Myc/Max, Sox2, Sox9, HIF1α, and Runx2). Abrogating RANK or its downstream c-Myc/Max or c-Met signaling network minimized or abolished skeletal metastasis in mice. RANKL-expressing LNCaP cells recruited and induced neighboring non metastatic LNCaP cells to express RANKL, c-Met/activated c-Met, while downregulating AR expression. These initially non-metastatic cells, once retrieved from the tumors, acquired the potential to colonize and grow in bone. These findings identify a novel mechanism of tumor growth in bone that involves tumor cell reprogramming via RANK–RANKL signaling, as well as a form of signal amplification that mediates recruitment and stable transformation of non-metastatic bystander dormant cells.
The Impact of Stochastic Extraction Cost on the Value of an Exhaustible Resource : The Case of the Alberta Oil Sands

In a much cited paper, Brennan and Schwartz (1985) demonstrated the application of contingent claims analysis to the valuation of a nonrenewable natural resources project when the decision-maker has flexibility to choose from several modes of operations open, closed and abandoned. The authors assumed fixed extraction costs and that the price of the resource follows Geometric Brownian Motion. The resulting stochastic optimal control problem must be solved numerically, such as with a finite difference approach. For natural resource extraction projects, uncertain costs are also important in optimal decisions and have been less studied in the literature. An example is the oils sands industry where natural gas is used as energy to extract the bitumen, and contributes more than 25 percent of the total per barrel cost. In this paper, we extend the Brennan and Schwartz (1985) model to account for stochastic extraction cost as well as stochastic convenience yield and resource price, and we study the impact on the value of an oil field and optimal decisions regarding extraction. We show that introducing stochastic extraction cost has a substantial impact on value and on the cut-off prices at which it is optimal for the field to switch from one operation mode to another. We use a relatively new method for the evaluation of American-type options the Least Squares Monte Carol method which can more easily deal with multiple stochastic factors than traditional numerical approaches. 1PhD candidate in Department of Economics, University of Waterloo, Waterloo ON, Canada 2Associate professor in Department of Economics, University of Waterloo, Waterloo ON, Canada
Central Nervous System Pathology Progresses Independently of KC and CXCR2 in Globoid-Cell Leukodystrophy

Globoid-cell Leukodystrophy (GLD; Krabbe’s disease) is a rapidly progressing inherited demyelinating disease caused by a deficiency of the lysosomal enzyme Galactosylceramidase (GALC). Deficiency of GALC leads to altered catabolism of galactosylceramide and the cytotoxic lipid, galactosylsphingosine (psychosine). This leads to a rapidly progressive fatal disease with spasticity, cognitive disability and seizures. The murine model of GLD (Twitcher; GALC−/−) lacks the same enzyme and has similar clinical features. The deficiency of GALC leads to oligodendrocyte death, profound neuroinflammation, and the influx of activated macrophages into the CNS. We showed previously that keratinocyte chemoattractant factor (KC) is highly elevated in the CNS of untreated Twitcher mice and significantly decreases after receiving a relatively effective therapy (bone marrow transplantation combined with gene therapy). The action of KC is mediated through the CXCR2 receptor and is a potent chemoattractant for macrophages and microglia. KC is also involved in oligodendrocyte migration and proliferation. Based on the commonalities between the disease presentation and the functions of KC, we hypothesized that KC and/or CXCR2 contribute to the pathogenesis of GLD. Interestingly, the course of the disease is not significantly altered in KC- or CXCR2-deficient Twitcher mice. There is also no alteration in inflammation or demyelination patterns in these mice. Furthermore, transplantation of CXCR2-deficient bone marrow does not alter the progression of the disease as it does in other models of demyelination. This study highlights the role of multiple redundant cytokines and growth factors in the pathogenesis of GLD.
A Norm-Based Analysis of Swearing Rendition in Professional Dubbing and Non-Professional Subtitling from English into Persian

This study takes a norm-based approach to analyzing the dubbing and non-professional subtitling of English swearing into Persian in an American movie. The article revolves around three main theoretical frameworks, i.e., Wajnryb (2005), Toury (1995, 2012a, 2012b), and Chesterman (1997). After analyzing the strategies in rendering the original swearing into Persian, the researchers achieved a model of four basic strategies: (a) direct translation with strong force, (b) direct translation with weak force, (c) deletion, and (d) foreignization. On the whole, the results of this research showed that both dubbed and non-professional subtitled versions were target language-oriented with deleting the original swearing as the most frequent strategy. But, the vulgarity and the degree of offensiveness of swearing in the original version were to some extent euphemized in the dubbed version. On the other hand, the non-professional subtitled version, in comparison with the dubbed version, employed more direct translation of the original swearing with strong force. The article then proceeded to delve into why these strategies were employed by the dubbed and non-professional subtitled producers, and why there were remarkable differences between the two versions. The findings provided useful information within descriptive translation studies nevertheless, they cannot be generalized since the study was limited by a relatively small corpus and utilized a non-probability sampling procedure.
Dietary Prebiotics, Milk Fat Globule Membrane, and Lactoferrin Affects Structural Neurodevelopment in the Young Piglet

Introduction Milk fat globule membrane (MFGM) and lactoferrin have been identified as two components that have potential to affect neurodevelopment. While concentrations of some MFGM constituents in infant formulas are within human milk range, they may not be present at optimal or clinically effective levels. However, lactoferrin levels of infant formulas are consistently reported to be lower than human milk. This study sought to provide a novel combination of prebiotics, bovine-derived MFGM, and lactoferrin and assess their influence on neurodevelopment. Methods Twenty-four male piglets were provided either TEST (n = 12) or CONT (n = 12) diet from 2 to 31 days of age. Piglets underwent spatial T-maze assessment starting at 17 days of age, were subjected to magnetic resonance imaging at 30 days of age, and were euthanized for tissue collection at 31 days of age. Results Diffusion tensor imaging revealed differences in radial (P = 0.032) and mean (P = 0.028) diffusivities in the internal capsule, where CONT piglets had higher rates of diffusion compared with TEST piglets. Voxel-based morphometry indicated larger (P < 0.05) differences in cortical gray and white matter concentrations, with CONT piglets having larger tissue clusters in these regions compared with TEST piglets. In the spatial T-maze assessment, CONT piglets exhibited shorter latency to choice compared with TEST piglets on day 2 of acquisition and days 3 and 4 of reversal. Conclusion Observed differences in microstructure maturation of the internal capsule and cortical tissue concentrations suggest that piglets provided TEST diet were more advanced developmentally than piglets provided CONT diet. Therefore, supplementation of infant formula with prebiotics, MFGM, and lactoferrin may support neurodevelopment in human infants.
Total daily energy expenditure is increased following a single bout of sprint interval training

Regular endurance exercise is an effective strategy for healthy weight maintenance, mediated via increased total daily energy expenditure (TDEE), and possibly an increase in resting metabolic rate (RMR: the single largest component of TDEE). Sprint interval training (SIT) is a low‐volume alternative to endurance exercise; however, the utility of SIT for healthy weight maintenance is less clear. In this regard, it is feasible that SIT may evoke a thermogenic response above and beyond the estimates required for prevention of weight gain (i.e., >200–600 kJ). The purpose of these studies was to investigate the hypotheses that a single bout of SIT would increase RMR and/or TDEE. Study 1: RMR (ventilated hood) was determined on four separate occasions in 15 healthy men. Measurements were performed over two pairs of consecutive mornings; each pair was separated by 7 days. Immediately following either the first or third RMR measurement (randomly assigned) subjects completed a single bout of SIT (cycle ergometer exercise). RMR was unaffected by a single bout of SIT (7195 ± 285 kJ/day vs. 7147 ± 222, 7149 ± 246 and 6987 ± 245 kJ/day (mean ± SE); P = 0.12). Study 2: TDEE (whole‐room calorimeter) was measured in 12 healthy men, on two consecutive days, one of which began with a single bout of SIT (random order). Sprint exercise increased TDEE in every research participant (9169 ± 243 vs. 10,111 ± 260 kJ/day; P < 0.0001); the magnitude of increase was 946 ± 62 kJ/day (~10%). These data provide support for SIT as a strategy for increasing TDEE, and may have implications for healthy body weight maintenance.
Specialization of modules

Let R be a polynomial ring over k(u), where k is a field k and u is a finite family or inderterminates. The paper introduces the specialization of an arbitrary finitely generated R-module by the substitution of u to elements of k. This definition does not depend on the presentation of the given module and preserves basic properties and operations on modules (e.g. annihilator, dimension, Ext and Tor) for almost all specializations.