Miracle-dz/UniFAR-FTUs huggingface dataset:
Freshwater Seepage Into Sediments of the Shelf, Shelf Edge, and Continental Slope of the Canadian Beaufort Sea

Long‐term warming of the continental shelf of the Canadian Beaufort Sea caused by the transgression associated with the last deglaciation may be causing decomposition of relict offshore subsea permafrost and gas hydrates. To evaluate this possibility, pore waters from 118 sediment cores up to 7.3‐m long were taken on the shelf and slope and analyzed for chloride concentrations and δ180 and δD composition. We observed downcore decreases in pore waters Cl− concentration in sediments from all sites from the inner shelf (<20‐m water depth), from the shelf edge, from the outer slope (down to 1,000‐m water depths), and from localized shelf features such as midshelf pingo‐like features and inner shelf pockmarks. In contrast, pore water freshening is absent from all investigated cores of the Mackenzie Trough. Downcore pore waters Cl− concentration decreases indicate regional widespread freshwater seepage. Extrapolations to zero Cl− of pore water Cl− versus δ180 regression lines indicate that freshwaters in these environments carry different isotope signatures and thus are sourced from different reservoirs. These isotopic signatures indicate that freshening of shelf sediments pore waters is a result of downward infiltration of Mackenzie River water, freshening of shelf edge sediments is due to relict submarine permafrost degradation or gas hydrate decomposition under the shelf, and freshening of slope sediments is consistent with regional groundwater flow and submarine groundwater discharge as far as 150 km from shore. These results confirm ongoing decomposition of offshore permafrost and suggest extensive current groundwater discharge far from the coast.
Serum cardiac troponin I concentration in dogs with precapillary and postcapillary pulmonary hypertension.

BACKGROUND Pulmonary hypertension (PH) is a disease condition leading to right-sided cardiac hypertrophy and, eventually, right-sided heart failure. Cardiac troponin I (cTnI) is a circulating biomarker of cardiac damage. HYPOTHESIS Myocardial damage can occur in dogs with precapillary and postcapillary PH. ANIMALS One hundred and thirty-three dogs were examined: 26 healthy controls, 42 dogs with mitral valve disease (MVD) without PH, 48 dogs with pulmonary hypertension associated with mitral valve disease (PH-MVD), and 17 dogs with precapillary PH. METHODS Prospective, observational study. Serum cTnI concentration was measured with a commercially available immunoassay and results were compared between groups. RESULTS Median cTnI was 0.10 ng/mL (range 0.10-0.17 ng/mL) in healthy dogs. Compared with the healthy population, median serum cTnI concentration was increased in dogs with precapillary PH (0.25 ng/mL; range 0.10-1.9 ng/mL; P < .001) and in dogs with PH-MVD (0.21 ng/mL; range 0.10-2.10 ng/mL; P < .001). Median serum cTnI concentration of dogs with MVD (0.12 ng/mL; range 0.10-1.00 ng/mL) was not significantly different compared with control group and dogs with PH-MVD. In dogs with MVD and PH-MVD, only the subgroup with decompensated PH-MVD had significantly higher cTnI concentration compared with dogs with compensated MVD and PH-MVD. Serum cTnI concentration showed significant modest positive correlations with the calculated pulmonary artery systolic pressure in dogs with PH and some echocardiographic indices in dogs with MVD and PH-MVD. CONCLUSIONS AND CLINICAL IMPORTANCE Serum cTnI is high in dogs with either precapillary and postcapillary PH. Myocardial damage in dogs with postcapillary PH is likely the consequence of increased severity of MVD.
Inhibition of Development of Abdominal Aortic Aneurysm by Glycolysis Restriction

Objective—The mechanisms underlying abdominal aortic aneurysm development remain unknown. We hypothesized that acceleration of glucose metabolism with the upregulation of glucose transporters is associated with abdominal aortic aneurysm development. Methods and Results—Enhanced accumulation of the modified glucose analogue 18 fluoro-deoxyglucose by positron emission tomography imaging in the human abdominal aortic aneurysm was associated with protein expressions of glucose transporters-1 and -3, assessed by Western blot. The magnitude of glucose transporter-3 expression was correlated with zymographic matrix metalloproteinase-9 activity. Intraperitoneal administration of glycolysis inhibitor with 2-deoxyglucose significantly attenuated the dilatation of abdominal aorta induced by periaortic application of CaCl2 in C57BL/6J male mice or reduced the aneurysmal formation in angiotensin II-infused apolipoprotein E knockout male mice. In monocytic cell line induced by phorbol 12-myristate 13-acetate or ex vivo culture obtained from human aneurysmal tissues, 2-deoxyglucose abrogated the matrix metalloproteinase-9 activity and interleukin-6 expression in these cells/tissues. Moreover, 2-deoxyglucose attenuated the survival/proliferation of monocytes and the adherence of them to vascular endothelial cells. Conclusion—This study suggests that the enhanced glycolytic activity in aortic wall contributes to the pathogenesis of aneurysm development. In addition, pharmacological intervention in glycolytic activity might be a potential therapeutic target for the disorder.
One Hundred Prisoners and a Lightbulb - Logic and Computation

This is a case-study in knowledge representation. We analyze the 'one hundred prisoners and a lightbulb' puzzle. In this puzzle it is relevant what the agents (prisoners) know, how their knowledge changes due to observations, and how they affect the state of the world by changing facts, i.e., by their actions. These actions depend on the history of previous actions and observations. Part of its interest is that all actions are local, i.e. not publicly observable, and part of the problem is therefore how to disseminate local results to other agents, and make them global. The various solutions to the puzzle are presented as protocols (iterated functions from agent's local states, and histories of actions, to actions). The computational aspect is about average runtime termination under conditions of random ('fair') scheduling. The paper consists of three parts. First, we present different versions of the puzzle, and their solution. This includes a probabilistic version, and a version assuming synchronicity (the interval between prisoners' interrogations is known). The latter is very informative for the prisoners, and allows different protocols (with faster expected termination). Then, we model the puzzle in an epistemic logic incorporating dynamic operators for the effects of information changing events. Such events include both informative actions, where agents become more informed about the non-changing state of the world, and factual changes, wherein the world and the facts describing it change themselves as well. Finally, we give the expected termination results of several protocols when assuming random scheduling. This paper integrates the literature and presents novel contributions. Novel are: Firstly, Protocol 2 and Protocol 4. Secondly, the modelling in dynamic epistemic logic in its entirety — we do not know of a case study that combines factual and informational dynamics in a setting of non-public events, or of a similar proposal to handle asynchronous behaviour in a dynamic epistemic logic. Thirdly, our computational results on Protocol 2 and results from manuscript (Wu 2002).
National Character Does Not Reflect Mean Personality Trait Levels in 49 Cultures

Most people hold beliefs about personality characteristics typical of members of their own and others' cultures. These perceptions of national character may be generalizations from personal experience, stereotypes with a “kernel of truth,” or inaccurate stereotypes. We obtained national character ratings of 3989 people from 49 cultures and compared them with the average personality scores of culture members assessed by observer ratings and self-reports. National character ratings were reliable but did not converge with assessed traits. Perceptions of national character thus appear to be unfounded stereotypes that may serve the function of maintaining a national identity.
Achieving Enterprise Architecture Benefits: What Makes the Difference?

Enterprise Architecture (EA) is rapidly becoming an established discipline. However, this does not mean that the practice of EA is already fully standardized. Practitioners as well as researchers report various techniques being used in the EA practice. And although EA has various potential benefits, evidence of real benefits is only just emerging. This paper presents empirical evidence of the relations between EA techniques used and EA benefits perceived, as well as the influence of contextual factors. The evidence is based on the results of a survey (n=293) held among both architects and stakeholders of EA in a wide variety of organizations. Employing multivariate regression analysis we found that the combination of project compliance, EA choices being explicitly linked to business goals and organized knowledge exchange between architects is a strong predictor for EA being perceived as a good instrument. We also established that significant differences exist in EA practice effectiveness between different economic sectors. Government appears to reap less benefits from EA than other sectors. The empirical evidence furthermore shows only a small influence of organizational size and number of architects on EA effectiveness.
Underwater 3D Surface Measurement Using Fringe Projection Based Scanning Devices

In this work we show the principle of optical 3D surface measurements based on the fringe projection technique for underwater applications. The challenges of underwater use of this technique are shown and discussed in comparison with the classical application. We describe an extended camera model which takes refraction effects into account as well as a proposal of an effective, low-effort calibration procedure for underwater optical stereo scanners. This calibration technique combines a classical air calibration based on the pinhole model with ray-based modeling and requires only a few underwater recordings of an object of known length and a planar surface. We demonstrate a new underwater 3D scanning device based on the fringe projection technique. It has a weight of about 10 kg and the maximal water depth for application of the scanner is 40 m. It covers an underwater measurement volume of 250 mm × 200 mm × 120 mm. The surface of the measurement objects is captured with a lateral resolution of 150 μm in a third of a second. Calibration evaluation results are presented and examples of first underwater measurements are given.
On the Structure of Real-Time Encoders and Decoders in a Multi-Terminal Communication System

A real-time communication system with two encoders communicating with a single receiver over separate noisy channels is considered. The two encoders make distinct partial observations of a Markov source. Each encoder must encode its observations into a sequence of discrete symbols. The symbols are transmitted over noisy channels to a finite memory receiver that attempts to reconstruct some function of the state of the Markov source. Encoding and decoding must be done in real-time, that is, the distortion measure does not tolerate delays. Under the assumption that the encoders' observations are conditionally independent Markov chains given an unobserved time-invariant random variable, results on the structure of optimal real-time encoders and the receiver are obtained. It is shown that there exist finite-dimensional sufficient statistics for the encoders. The problem with noiseless channels and perfect memory at the receiver is then considered. A new methodology to find the structure of optimal real-time encoders is employed. A sufficient statistic with a time-invariant domain is found for this problem. This methodology exploits the presence of common information between the encoders and the receiver when communication is over noiseless channels.
Physicochemical processes in the magma chamber under the black mountain porphyry Cu-Au deposit, Philippines: insights from mineral chemistry and implications for mineralization

The Black Mountain porphyry Cu-Au deposit in the Baguio district, Northern Luzon (Philippines) is associated with late Miocene to Pliocene intrusive rocks that retain primary crystallization signatures, providing an excellent natural laboratory to study the details of magma chamber processes. Each igneous phase contains disequilibrium textures, including resorptive textures in plagioclase and distinct core rim textures in amphibole. High crystallization temperatures and pressures in felsic (~880°C and ~2.8 kbar) and mafic (~1,030°C and ~7.7 kbar) rocks recorded by amphibole phenocrysts reflect crystallization in the magma chamber. Amphibole in felsic rocks aged 6.39 ± 0.49 to 2.83 ± 0.23 Ma have similar crystallization temperatures and pressures, suggesting a long-lived and hot felsic magma chamber under the Black Mountain deposit. Four independent oxybarometers, including amphibole, coexisting magnetite-ilmenite, magmatic anhydrite, and zircon, consistently show a high oxidation state of >NNO+1 for the felsic magma and ~NNO+0.7 for the mafic magma. Element profiles across phenocrystic plagioclase display repeated oscillatory variations of Ca, Fe, and Sr contents with large anorthite variations and a positive correlation between CaO and FeO. The amphibole is classified as group 1 Mg hornblende to tschermakite-hornblende in felsic rocks and group 2 Mg hastingsite in mafic rocks. The group 1 amphiboles show a variety of major and trace element variations from core to rim in disequilibrated grains and transitional compositions to group 2 Mg hastingsite. Both mineral textures and chemistry recorded by phenocrysts of plagioclase and amphibole indicate repeated mafic magma recharge in the felsic magma chamber. The common occurrence of rounded or elongated sulfide inclusions in the megacrystic amphibole from the mafic rocks (2.81 ± 0.15 Ma) suggests a greater enrichment of Cu in mafic rocks relative to the ore-forming porphyries (2.91–2.83 Ma). This is also consistent with higher Cu contents (3.4 ± 0.9 ppm) in the megacrystic amphibole from the mafic rocks relative to amphibole in felsic rocks (1.0 ± 0.2 ppm) and may indicate up to 3.4 times higher Cu in the mafic magma relative to felsic magma. Therefore, large-scale mafic magma recharge (particularly at ~2.8 Ma), likely introduced ore-forming metals to the long-lived felsic magma chamber, further contributing to the fertility of the felsic rocks and ultimately to Cu-Au mineralization at the Black Mountain deposit.
Code Design for Short Blocks: A Survey

The design of block codes for short information blocks (e.g., a thousand or less information bits) is an open research problem which is gaining relevance thanks to emerging applications in wireless communication networks. In this work, we review some of the most recent code constructions targeting the short block regime, and we compare then with both finite-length performance bounds and classical error correction coding schemes. We will see how it is possible to effectively approach the theoretical bounds, with different performance vs. decoding complexity trade-offs.
A Harmonic Class-C CMOS VCO-Based on Low Frequency Feedback Loop: Theoretical Analysis and Experimental Results

A novel harmonic Class-C CMOS VCO architecture with improved phase noise performance and power efficiency is presented in this paper. The VCO is based on the widely adopted topology consisting in a crossed pair of NMOS devices refilling a symmetric resonator with a center tapered inductor and biased by a top PMOS current generator. The Class-C operation mode is obtained through a low frequency feedback loop constituted by an operational transconductance amplifier operating the difference between the inductor center tap voltage and a reference voltage, pushing gate polarization voltage of VCO crossed pair devices well below their threshold voltage. The Class-C VCO achieves a theoretical 2.9 dB phase noise improvement compared to the standard differential-pair LC-tank oscillator for the same current consumption. A prototype of the VCO is implemented in a standard RF 55 nm CMOS technology and compared to both a standard and an optimized VCO implemented in the same technology. All these VCOs share a copy of a unique resonator. The Class-C VCO is tunable over the frequency band 6.5-7.8 GHz and displaying an average phase noise lower than -127 dBc/Hz @ 1 MHz offset with a power consumption of 18 mW, for a state-of-the-art figure-of-merit of -187 dBc/Hz @ 1 MHz and -191 dBc/Hz @ 10 MHz offsets, respectively.
Lack of Buffering by Composites Promotes Shift to More Cariogenic Bacteria

Secondary caries (SC) remains a very important problem with composite restorations. The objectives of this study were to test the acid-buffering ability of several restorative materials and to evaluate whether buffering of the restorative material has an impact on the microbial composition of the biofilm. Disk-shaped specimens of conventional composite, composite with surface prereacted glass-ionomer filler particles (so-called giomer), glass-ionomer cement (GIC), amalgam, and hydroxyapatite (HAp) (control) were exposed to aqueous solutions with pH 4, 5, 6, and 7 and to the medium containing bacteria-produced acids, and pH changes were recorded over several days. Next, material specimens were immersed in bacterial growth medium with pH adjusted to 5. After a 24-h incubation, the extracts were collected and inoculated with a cariogenic (Streptococcus mutans) and a noncariogenic (Streptococcus sanguinis) species. The bacterial growth was monitored both in a single-species model by spectrophotometry and in a dual-species model by viability quantitative polymerase chain reaction. Amalgam and HAp showed the strongest acid-buffering ability, followed by the GIC and the giomer, while the conventional composite did not exhibit any buffering capacity. Furthermore, due to the lack of acid-buffering abilities, composite was not able to increase the pH of the medium (pH 5), which, in the absence of antibacterial properties, allowed the growth of S. mutans, while the growth of S. sanguinis, a less aciduric species, was completely inhibited. A similar effect was observed when bacteria were cultured together: there was a higher percentage of S. mutans and lower percentage of S. sanguinis with the conventional composite than with other materials and HAp. In conclusion, conventional composites lack the ability to increase the local pH, which leads to the outgrowth of more acidogenic/aciduric bacteria and higher cariogenicity of the biofilm. Together with lack of antibacterial properties, lack of buffering may account for the higher susceptibility of composites to SC.
Lexical neighborhood effects in phonetic processing.

Previous research on spoken word recognition has demonstrated that identification of a phonetic segment is affected by the lexical status of the item in which the segment occurs. W. F. Ganong (1980) demonstrated that a category boundary shift occurs when the voiced end of 1 voice-onset time continuum is a word but the voiceless end of another series is a word; this is known as the "lexical effect. " A series of studies was undertaken to examine how lexical neighborhood; in contrast to lexical status, might influence word perception. Pairs of nonword series were created in which the voiced end of 1 series had a higher frequency-weighted neighborhood density, whereas the reverse was true for the other series. Lexical neighborhood was found to affect word recognition in much the same way as lexical status.
Research Paper: Types of Unintended Consequences Related to Computerized Provider Order Entry

OBJECTIVE To identify types of clinical unintended adverse consequences resulting from computerized provider order entry (CPOE) implementation. DESIGN An expert panel provided initial examples of adverse unintended consequences of CPOE. The authors, using qualitative methods, gathered and analyzed additional examples from five successful CPOE sites. METHODS Using a card sort method, the authors developed a categorization scheme for the 79 unintended consequences initially identified and then iteratively modified the scheme to categorize 245 additional adverse consequences resulting from fieldwork. Because the focus centered on consequences requiring prevention or remedial action, the authors did not further analyze reported unintended beneficial (positive) consequences. RESULTS Unintended adverse consequences (UACs) fell into nine major categories (in order of decreasing frequency): 1) more/new work for clinicians; 2) unfavorable workflow issues; 3) never ending system demands; 4) problems related to paper persistence; 5) untoward changes in communication patterns and practices; 6) negative emotions; 7) generation of new kinds of errors; 8) unexpected changes in the power structure; and 9) overdependence on the technology. Clinical decision support features introduced many of these unintended consequences. CONCLUSION Identifying and understanding the types and in some instances the causes of unintended adverse consequences associated with CPOE will enable system developers and implementers to better manage implementation and maintenance of future CPOE projects.
A central region of Gli2 regulates its localization to the primary cilium and transcriptional activity

ABSTRACT Signaling through vertebrate Hedgehog (Hh) proteins depends on the primary cilium. In response to Hh signals, the transcriptional activator of the pathway, Gli2, accumulates at the ciliary tip, raising the possibility that ciliary localization is important for Gli2 activation. To test this hypothesis, we used the Floxin system to create knock-in Gli2 alleles in embryonic stem cells (ESCs) to allow methodical testing of which domains and residues are essential for the ciliary localization of Gli2. The Gli2 zinc fingers, transcriptional activation domain, repressor domain, phosphorylation cluster and a Sufu binding motif were each dispensable for ciliary localization. Mutating residues that are required for Gli2 sumoylation and nuclear trafficking also did not abrogate ciliary localization. By contrast, several other domains restricted Gli2 nuclear localization, and a central region, distinct from previously characterized domains, was required for ciliary localization. In addition to an inability to localize to cilia, Gli2 lacking this central domain was unable to activate target genes. Thus, our systematic analysis in ESCs reveals that distinct regions of Gli2 regulate its nuclear and ciliary localization. The identification of a domain essential for both ciliary localization and transcriptional activity suggests that ciliary localization of Gli2 is required for its activation.