Miracle-dz/UniFAR-FTUs huggingface dataset:
A role for CCL2 in both tumor progression and immunosurveillance

The chemokine CCL2, which is best known for its chemotactic functions, is expressed not only by immune cells, but also by several types of malignant and stromal cells. CCL2 has been shown to exert both pro- and anti-tumor effects. However, recent results demonstrate a main role for CCL2 in tumor progression and metastasis, suggesting that this chemokine may constitute a therapeutic target for anticancer drugs. Mammary carcinoma models, including models of implantable, transgenic, and chemically-induced tumors, were employed in the setting of Ccl2 or Ccr2 knockout mice or CCL2 neutralization with a monoclonal antibody to further investigate the role of the CCL2/CCR2 signaling axis in tumor progression and metastatic spread. In our implantable tumor models, an anti-CCL2 monoclonal antibody inhibited the growth of primary malignant lesions in a biphasic manner and reduced the number of metastases. However, in Ccl2−/− or Ccr2−/− mice developing implanted or transgenic tumors, the number of pulmonary metastases was increased despite a reduction in the growth rate of primary neoplasms. Transgenic Mtag.Ccl2−/− or Mtag.Ccr2−/− mice also exhibited a significantly earlier of disease onset. In a chemical carcinogenesis model, anti-CCL2 monoclonal antibody inhibited the growth of established lesions but was ineffective in the tumor induction phase. In contrast to previous studies indicating a role for CCL2 in the establishment of metastases, we have demonstrated that the absence of CCL2/CCR2-signaling results in increased metastatic disease. Thus, the CCL2/CCR2 signaling axis appears to play a dual role in mediating early tumor immunosurveillance and sustaining the growth and progression of established neoplasms. Our findings support the use of anti-CCL2 therapies for the treatment of established breast carcinoma, although the complete abrogation of the CCL2 signaling cascade may also limit immunosurveillance and support metastatic spread.
The effector component of the cytotoxic T-lymphocyte response has a biphasic pattern after burn injury.

INTRODUCTION Burn injury delays allograft rejection and impairs the host defense against infection. These functions are mediated via the cytotoxic T-lymphocyte (CTL) response. The CTL response is divided into antigen recognition/processing and effector phases. Presensitization allows selective analysis of changes, induced by burn injury, in the effector limb of the CTL response in relation to time and burn size. METHODS Anesthetized CBA mice were primed with either a flank allograft from C57BL/6 (B6) mice or an autograft (negative control). Five weeks after grafting, animals were anesthetized and received either a 0, 20, or 40% burn. Spleens were harvested 3, 7, 10, and 14 days after burn injury (n = 96), cocultured with B6 stimulator splenocytes, and assessed for CTL response to radiolabeled allogeneic targets in a 51Cr release assay. In experiment 2, spleens were harvested from unburned and 40% burned animals on Postburn Days 3 and 14. After triple staining, cells were analyzed by flow cytometry for CD4, CD8, and CD25 antigens. In experiment 3, splenocytes from 0 and 40% burned animals on Postburn Days 3 and 14, were cocultured with B6 stimulators for 5 days. Supernatants were evaluated for interleukin (IL)-2, IL-5, and interferon-gamma (IFN-gamma) using ELISA: RESULTS The CTL response for 20 and 40% burned animals decreased 3 days postburn (-11.9 and -30.1%, P < 0.05), returned to baseline in 7-10 days, and was increased by 14 days postburn (15.8 and 22.6%, P < 0.05). The T-helper lymphocyte population (CD4) from 40% burn animals was significantly decreased on Postburn Days 3 and 14 (10.12 +/- 0.45% vs 11.78 +/- 0.29% and 10.19 +/- 0.24% vs 14.21 +/- 0.97%, respectively, P < 0.05). The CTL effector (CD8) splenocyte population was significantly higher in the burned animals on Postburn Day 14 (4.55% vs 3.71%, P < 0.05). On Postburn Day 3, average IL-5 production was higher in the burned animals (1.80 pg/ml vs 0.59 pg/ml, respectively, P < 0.05). The burn group, on Postburn Days 3 and 14, showed a decrease in mean IL-2 production (212.81 pg/ml vs 263.6 pg/ml and 342.7 pg/ml vs 421.4 pg/ml, respectively, P < 0.05). Mean IFN-gamma production on Postburn Days 3 and 14 was decreased in burned mice (263.75 pg/ml vs 285.57 pg/ml and 218.16 pg/ml vs 263.42 pg/ml, P < 0.05). CONCLUSIONS Burn injury impairs the effector limb of the CTL response as a function of burn size in the immediate postburn period. CTL activity returns to baseline within 7-10 days postburn and has a rebound increase by Day 14. Early CTL suppression, after burn injury, may be due to a decrease in the T-helper subpopulation. The late increase in cytotoxicity may be secondary to an increase in the effector CTL population in the late postburn period. Burn injury causes a T-helper-2 phenotype as demonstrated by depressed IL-2 and IFN-gamma production and increased IL-5 production.
A randomized, controlled trial of the effectiveness of cognitive-behavioral therapy and sertraline versus a waitlist control group for anxiety disorders in older adults.

OBJECTIVE This study is the first to investigate the relative effectiveness of cognitive-behavioral therapy (CBT) compared with a selective serotonin reuptake inhibitor (SSRI; sertraline) in a randomized, controlled trial on the treatment of anxiety disorders in older adults. METHOD Eighty-four patients 60 years of age and over with a principal diagnosis of generalized anxiety disorder, panic disorder, agoraphobia, or social phobia were randomly assigned to one of three conditions: 15 sessions of CBT, pharmacologic treatment with an SSRI (sertraline; maximum dosage 150 mg), or a waitlist control group. Participants completed measures of primary outcome (anxiety) and coexistent worry and depressive symptoms at baseline, posttreatment, and at three-month follow up. RESULTS Attrition rates were high in both treatment groups. Consequently, findings are based on a relatively small sample of completers (N = 52). Although both CBT and sertraline led to significant improvement in anxiety, worry, and depressive symptoms both at posttreatment and at three-month follow up, sertraline showed superior results on worry symptoms. Effect size estimates for CBT were in the small to medium range both at posttreatment (mean d = 0.42) and at three-month follow up (mean d = 0.35), whereas effect sizes for sertraline fell into the large range (posttreatment mean d = 0.94 and three-month follow up mean d = 1.02). The waitlist condition showed virtually no effects (posttreatment mean d = .03). CONCLUSIONS Our findings strongly suggest that the pharmacologic treatment of late-life anxiety with SSRIs has not been given the proper attention in research to date.
Dynamic gridmaps: comparing building techniques

Mobile robots need to represent obstacles in their surroundings, even moving ones, to make right movement decisions. For higher autonomy the robot should automatically build such representation from its sensory input. This paper compares the dynamic character of several gridmap building techniques: probabilistic, fuzzy, theory of evidence and histogramic. Two criteria are defined to rank such dynamism in the representation: time to show a new obstacle and time to show a new hole. The update rules for first three such techniques hold associative property which confers them static character, inconvenient for dynamic environments. Major contribution of this paper is the
Interactions between cancer and bone marrow cells induce osteoclast differentiation factor expression and osteoclast-like cell formation in vitro.

Cancer cells metastasized to bone induce osteoclastogenesis for bone destruction. Coculture of either mouse melanoma B16 or breast cancer Balb/c-MC cells with mouse bone marrow cells (BMCs) induced osteoclast-like cells, which were not observed when cancer cells were segregated from BMCs. Osteoclast differentiation factor (ODF), also known as receptor activator of NF-kappaB ligand (RANKL), is a direct mediator of many osteotropic factors. Neither BMCs, B16 nor Balb/c-MC cells alone expressed ODF mRNA. However, coculture of these cancer cells with BMCs induced ODF expression, which was prevented by indomethacin. Moreover, the coculture with cancer cells inhibited secretion of osteoprotegerin/osteoclastogenesis inhibitory factor (OPG/OCIF), an inhibitory decoy receptor for ODF, from BMCs. Thus, enhanced osteoclastogenesis in the presence of cancer cells might be due to an increase in ODF activity. These results suggest that interactions between cancer cells and BMCs induce ODF expression and suppress OPG/OCIF level in metastatic foci resulting in pathological osteoclastogenesis for bone destruction.
Analysis of serum antibody profile against H pylori VacA and CagA antigens in Turkish patients with duodenal ulcer.

AIM To investigate the frequency of seropositivity against CagA, VacA proteins and to determine their independent effects on the development of duodenal ulcer (DU) in Turkish patients. METHODS The study was designed as a prospective one from a tertiary referral hospital. Dyspeptic patients who were referred to our endoscopy unit for upper gastrointestinal endoscopy between June 2003 and March 2004 and diagnosed to have DU or nonulcer dyspepsia (NUD) were included. Biopsies from the antrum and body of the stomach were taken in order to assess the current H pylori status by histology, rapid urease test and culture. Fasting sera were obtained from all patients and H pylori status of all sera was determined by IgG antibodies using an enzyme-linked immunosorbent assay (ELISA) kit. All seropositive patients were further analysed using Western blot assays detecting IgG antibodies against CagA and VacA proteins. The c2 test was used for statistical comparison of the values and age-sex adjusted multiple regression analysis was used to determine the independent effects of CagA and VacA seropositivities on the development of DU. RESULTS Sixty-three patients with DU and 62 patients with NUD were eligible for the final analysis. Seropositivity for anti-CagA was detected in 51 of 62 (82%), and in 55 of 63 (87%) patients with NUD and DU, respectively (P = no significance), and seropositivity for anti-VacA was found in 25 of 62 (40% ) and in 16 of 63 (25%) patients, with NUD and DU, respectively. CONCLUSION These findings suggest that none of these virulence factors is associated with the development of DU in the studied Turkish patients with dyspepsia.
Involvement in Alcoholics Anonymous by Persons with Dual Disorders

Forty subjects with serious mental illness and alcoholism were interviewed about their experiences with Alcoholics Anonymous. All had attended one or more meetings of special AA groups for dually diagnosed members. Information was obtained about their illness, heir first meeting, how they used the groups, and ways in which they participated in meetings. Investigators found that intensity of AA involvement was related to the degree of comfort they felt in groups. Demographic and personality characteristics did not correlate with involvement. A majority of subjects maintained their involvement in the meetings of special AA groups or in regular AA meetings.
Indigenous Rights in Chile: National Identity and Majority Group Support for Multicultural Policies

We examine support for policies affecting indigenous ethnic minorities in Chile. Specifically, we examine the role of national group definitions that include the largest indigenous group—the Mapuche—in different ways. Based on questionnaire data from nonindigenous Chilean students (N = 338), we empirically distinguish iconic inclusion, whereby the Mapuche are seen as an important part of Chile's history and identity on the one hand, from egalitarian inclusion, which represents the Mapuche as citizens of equal importance to the nonindigenous majority on the other. Both forms of inclusion positively predict support for indigenous rights, independent of participants' political affiliation, strength of national identification, and social distance. A second study (N = 277) replicates this finding whilst controlling for right-wing authoritarianism, social dominance orientation, blind patriotism, and constructive patriotism. It also finds iconic inclusion to be predictive of a pro-Mapuche position regarding the unrest over the issue of ancestral land in 2009. We conclude that understanding how national identity affects attitudes about minority rights necessitates appreciating the importance of particular meanings of nationality, and not only the strength of identification.
Reading Proficiency and Orthography Evidence from Hebrew and English

We conducted two experiments to test whether the orthography of readers’ first or second languages affects their reading time and comprehension in each. In both experiments, very skilled bilinguals read texts translated from Hebrew to English, or from English to Hebrew. Half the texts were originally written in Hebrew and the other half in English. In the first experiment, 24 native Hebrew speakers read two passages of four texts in the Hebrew version. Each read one of the texts voweled and the other one unvoweled. Twelve native English speakers read two passages from the same four texts in English. Participants in the study were either students or teachers at the University of Haifa. The English native speakers read the EngLish texts significantly faster than the native Hebrew speakers read the same texts in their Hebrew version. The origin of the text (English or Hebrew) and vowelization were nonsignificant, as was any interaction between the main factors. The comprehension of the Hebrew voweled texts was nearly significantly better than was the comprehension of the Hebrew unvoweled texts. In the second experiment, 24 advanced bilingual, Hebrew native speakers read two passages in Hebrew (one voweled and the other unvoweled) and two in English. Again, the reading time in English was significantly shorter. Post-hoc comparisons showed that readingtime was shorter in English than in unvoweled Hebrew, but not shorter than in voweled Hebrew. Comprehension of English was not significantly different from comprehension of voweled Hebrew, but was significantly better than comprehension of unvoweled Hebrew.
Exploring the Work and Family Relationship

This article examines gender differences in the influence of parenthood and social support on job satisfaction. This is important because there is ample evidence that work and family roles are managed and coordinated differently by men and women and therefore that home roles influence men's and women's job satisfaction differentially. Using a large random sample of the Toronto metropolitan area, gender differences in the impact of parenthood and social support from partners and coworkers on job satisfaction, controlling for job demands, are examined. Results indicate that mothers have higher job satisfaction than fathers and nonmothers. Coworker support is more important for men's job satisfaction than partner support. Partner support is highly significant for women's job satisfaction, whereas the influence of coworker support varies as a function of partner support. Implications for an understanding of gender differences in job satisfaction and in the experience of dual roles are discussed.
THE POLITICS OF CODESWITCHING AND LANGUAGE CHOICE

Using data from ethnographic studies of the use of French and English in Ontario and Quebec (Canada) in a variety of settings (hospital, factory, school, etc.) over the period 1978–1990, I discuss language choice as a political strategy, especially as a strategy of ethnic mobilisation. More broadly, I argue that codeswitching must be understood in terms of individual communicative repertoires and community speech economies, particularly as these are tied to a political economic analysis of the relationship between the availability and use of linguistic varieties, on the one hand, and the production and distribution of symbolic and material resources on the other.
Maltrato entre pares: conductas de intimidación y victimización en escolares chilenos

Se presenta un estudio de conductas de intimidacion y victmizacion en 1167 escolares de 6o, 7o y 8o ano Basico de la Region de Valparaiso, Chile. Se utilizo la bateria Insebull (Aviles & Elices, 2007). Los resultados indican que 9% ha sido victima del maltrato de sus companeros bastantes veces o casi todos los dias durante el ano escolar. El maltrato psicologico es mas frecuente que la agresion fisica, destacandose el uso de medios virtuales. Los participantes suelen ser varones que actuan en grupo. Los lugares mas frecuentes son la sala de clases y el patio de recreo, en ausencia del profesor. La mayoria senala no saber, o solo difusamente, las razones que subyacen a estos actos, y no hacer nada frente a actos observados. Estos resultados coinciden con los estudios a nivel internacional, y permiten comprender el maltrato entre pares en contextos especificos de la realidad educativa chilena.
Predicting Adolescent Healthy Eating Behavior Using Attitude, Subjective Norm, Intention, and Self-schema

Eating behavior established in adolescence has been linked to the risks of many chronic illnesses in adulthood. The present study aims to predict healthy eating behavior in Thai early adolescents using attitude, subjective norm, intention, and self-schema. The participants were 191 early adolescents studying in grade 7-9 in public schools in Bangkok Metropolitan. The questionnaires consist of the Attitude towards Healthy Eating Scale, the Subjective Norm for Healthy Eating Scale, the Intention to Eat Healthily Scale, and the Healthy Eater Self-Schema Scale. The Healthy Eating Index, using the Nutrition Flag and Dietary Reference Intake for Thai (DRI) 2003 as references, was used to determine healthy eating behavior of all participants through a 3-days food diary. All participants were also trained for food recording to ensure the accuracy of their intake data. Results from hierarchical multiple regression revealed that subjective norm was the only significant predictor of healthy eating intention in all participants (p < .05). Only in the girls group that attitude could predict healthy eating intention. However, self-schema could predict healthy eating behavior in the boys group (p < .05). These findings suggest that factors predicting healthy eating behavior among early adolescent girls and adolescent boys are different. Thus, different strategies based on specific cognitive factors should be employed when promoting healthy eating behavior in early adolescents.
Effect of 8-Week High-Intensity Stretching Training on Biceps Femoris Architecture

Abstract Freitas, SR and Mil-Homens, P. Effect of 8-week high-intensity stretching training on biceps femoris architecture. J Strength Cond Res 29(6): 1737–1740, 2015—Previous studies have reported no changes on muscle architecture (MA) after static stretching interventions; however, authors have argued that stretching duration and intensity may not have been sufficient. A high-intensity stretching intervention targeting the knee flexors with an 8-week duration was conducted to observe the effects on biceps femoris long head (BF) architecture. Participants (n = 5) performed an average of 3.1 assisted-stretching sessions per week, whereas a control group (n = 5) did not perform stretching. The knee extension passive maximal range of motion (ROM), and BF fascicle length (FL), fascicle angle, and muscle thickness were assessed before and after the intervention. A significant increase was observed for FL (+12.3 mm, p = 0.04) and maximal ROM (+14.2°, p = 0.04) for the stretching group after the intervention. No significant changes were observed for the control group in any parameter. An 8-week high-intensity stretching program was observed to efficiently increase the BF FL, as well as the knee extension maximal ROM. Stretching intensity and duration may play an important role on MA adaptation.
Number and Quality of Roles: A Longitudinal Personality View

We used longitudinal personality data to test whether number and quality of roles were associated with health and self-enhancement in 100 privileged midlife women. Number of roles (from the set of partner, parent, and worker) was not related to autonomy, individuality, and complexity, as had been hypothesized, but to respect for norms, being well-organized and considering oneself like other people. Though women with one role were lower in well-being than women with more than one, hierarchical multiple regression showed no advantage to number of roles after psychological health at age 21 was taken into account. However, quality of role, as assessed by marital satisfaction and status level in work, was associated with contentment and effective functioning, respectively, even after antecedent psychological functioning was taken into account. Particular roles were associated with particular advantages. The enhancement model of the accumulation of roles is compared with Erikson's theory of the development of personality.
An airborne 95 GHz dual-polarized radar for cloud studies

A 95 GHz dual-polarization radar system was developed and flown on the University of Wyoming King Air research aircraft, from which it measured reflectivity, depolarization, and Doppler-derived velocity mean and standard deviation of a variety of clouds. This paper describes the radar and a data acquisition system that uses commercially available digitizers, signal processors, and signal generators. The authors also describe the tradeoffs between spatial resolution and ability to estimate reflectivity and velocity. This paper presents the first known airborne measurements of clouds made at 95 GHz; these are thought to be the most highly resolved millimeter-wave cloud images made to date. Depolarization, measured in terms of the linear depolarization ratio (LDR), was especially high in the melting band and in regions containing pristine ice crystals. These measurements demonstrate the advantages that high-spatial-resolution airborne millimeter-wave radars offer for the study of cloud microphysical properties. >
Individualist and collectivist norms: when it's ok to go your own way

We conducted two studies to investigate the influence of group norms endorsing individualism and collectivism on the evaluations of group members who display individualist or collectivist behaviour. It was reasoned that, overall, collectivist behaviour benefits that group and would be evaluated more positively than would individualist behaviour. However, it was further predicted that this preference would be attenuated by the specific content of the group norm. Namely when norms prescribed individualism, we expected that preferences for collectivist behaviour over individualist behaviour would be attenuated, as individualist behaviour would, paradoxically, represent normative behaviour. These predictions were supported across two studies in which we manipulated norms of individualism and collectivism in an organizational role-play. Furthermore, in Study 2, we found evidence for the role of group identification in moderating the effects of norms. The results are discussed with reference to social identify theory and cross-cultural work on individualism and collectivism. Copyright (C) 2002 John Wiley Sons, Ltd.