Miracle-dz/UniFAR-FTUs huggingface dataset:
Object Detection for Comics using Manga109 Annotations

With the growth of digitized comics, image understanding techniques are becoming important. In this paper, we focus on object detection, which is a fundamental task of image understanding. Although convolutional neural networks (CNN)-based methods archived good performance in object detection for naturalistic images, there are two problems in applying these methods to the comic object detection task. First, there is no large-scale annotated comics dataset. The CNN-based methods require large-scale annotations for training. Secondly, the objects in comics are highly overlapped compared to naturalistic images. This overlap causes the assignment problem in the existing CNN-based methods. To solve these problems, we proposed a new annotation dataset and a new CNN model. We annotated an existing image dataset of comics and created the largest annotation dataset, named Manga109-annotations. For the assignment problem, we proposed a new CNN-based detector, SSD300-fork. We compared SSD300-fork with other detection methods using Manga109-annotations and confirmed that our model outperformed them based on the mAP score.
Burnout and Resiliency Among Family Medicine Program Directors.

BACKGROUND AND OBJECTIVES Nearly one-half (46%) of physicians report at least one symptom of burnout. Family medicine residency program directors may have similar and potentially unique levels of burnout as well as resiliency. The primary aims of this study were to examine burnout and resiliency among family medicine residency directors and characterize associated factors. METHODS The questions used were part of a larger omnibus survey conducted by the Council of Academic Family Medicine (CAFM) Educational Research Alliance (CERA) in 2016. Program and director-specific characteristics were obtained. Symptoms of burnout were assessed using two single-item measures adapted from the full Maslach Burnout Inventory, and level of resiliency was assessed using the Brief Resilience Scale. RESULTS The overall response rate for the survey was 53.7% (245/465). Symptoms of high emotional exhaustion or high depersonalization were reported in 27.3% and 15.8% of program directors, respectively. More than two-thirds of program directors indicated that they associated themselves with characteristics of resiliency. Emotional exhaustion and depersonalization were significantly correlated with never having personal time, an unhealthy work-life balance, and the inability to stop thinking about work. The presence of financial stress was significantly correlated with higher levels of emotional exhaustion and depersonalization. In contrast, the level of resiliency reported was directly correlated with having a moderate to great amount of personal time, healthy work-life balance, and ability to stop thinking about work, and negatively correlated with the presence of financial stress. CONCLUSIONS Levels of emotional exhaustion, depersonalization, and resiliency are significantly related to personal characteristics of program directors rather than characteristics of their program.
Telephone helplines as a source of support for eating disorders: Service user, carer, and health professional perspectives

ABSTRACT Access to care for eating disorders can be problematic for numerous reasons including lack of understanding and delays with treatment referrals. Previous research has highlighted the benefits of telephone helplines as an accessible source of support for those who may not wish to access face-to-face support or to fill a gap for those waiting for treatment. This study aimed to gain an insight into the perspectives of those who may use or refer others to a telephone helpline in order to identify the requirements of such a service. Triangulation of service user, carer and health professionals’ perspectives resulted in identification of themes relating to the type of support, delivery and practicalities of a helpline. The findings indicated that telephone helplines may offer numerous benefits for individuals with an eating disorder, whether accessed as a first step, alongside treatment or as an extension of this support when in recovery. Additionally helplines may provide an opportunity for carers to access information and discuss their own experiences, while supporting their loved one. Raising awareness of these services is important to encourage those affected by an eating disorder to access and make the most of this type of support. These findings offer an insight into the key requirements for new and existing service development with regard to both the type of support and the method of communication required by individuals with eating disorders.
Knowledge and attitude of sexually transmitted diseases among adolescents in Ikeji-Arakeji, Osun State, in South-Western Nigeria.

BACKGROUND Globally, sexually transmitted disease (STD) is a public health problem. In Nigeria, adolescents form a substantial proportion (22%) of the population and are particularly prone to STDs because of the influence of peer pressure and urge to experiment sexual activity. The study examined the knowledge and attitude of adolescents towards the prevention of sexually transmitted diseases. METHOD The survey study was descriptive cross- sectional and carried out among consenting secondary school students aged 10-24 years completing a self- administered questionnaire on knowledge and attitude in relation to sexually transmitted diseases in Ikeji- Arakeji, Oriade Local government, Osun State, Nigeria. The proportionate sampling technique was used to recruit 341 participants into the study. Data were analyzed using descriptive and inferential statistics. RESULTS Male-Female distributions were 46.3% and 53.7% respectively. Mean age at first sex (sex initiation) was 16.8 years (approximately 17years) and about 97% of the respondents knew about STDs. The media/ magazine was the major source of information about STDs, accounting for more than half (57%) of the responses on sources of STD information followed closely from that from friends with 31%. Parent's source of information was about 11%. Knowledge of STDs centred mainly on HIV/AIDS with 83% and there was a poor knowledge (78%) of its symptoms. About 40% of all respondents had initiated sex at the time of the study and 46% of the adolescents, as against 54%, thought it was bad to initiate sex before marriage. There was a significant association between perception about initiating sex before marriage and ever having sex using bivariate analysis x(2)=268.4, P<0.001). Also, there was a significant difference between the different groups (sources of information) in influencing sex initiation (F=318.47 and P=0.000). Post-hoc analysis showed that each of the different groups (sources of information) was distinct. CONCLUSION Adolescents' knowledge of STDs generally limited to HIV/AIDS and perception about sex significantly influenced the decision to initiate sex. There is, therefore, a serious need to implement sexual education and other sexual and reproductive health interventions early for adolescents in Nigeria.
Three‐dimensional co‐culture of human hepatocytes and mesenchymal stem cells: improved functionality in long‐term bioreactor cultures

The development of human cell models that can efficiently restore hepatic functionality and cope with the reproducibility and scalability required for preclinical development poses a significant effort in tissue engineering and biotechnology. Primary cultures of human hepatocytes (HHs), the preferred model for in vitro toxicity testing, dedifferentiate and have short‐term viability in two‐dimensional (2D) cultures. In this study, hepatocytes isolated from human liver tissue were co‐cultured with human bone marrow mesenchymal stem cells (BM‐MSCs) as spheroids in automated, computer‐controlled, stirred‐tank bioreactors with perfusion operation mode. A dual‐step inoculation strategy was used, resulting in an inner core of parenchymal liver tissue with an outer layer of stromal cells. Hepatocyte polarization and morphology as well as the mesenchymal phenotype of BM‐MSCs were maintained throughout the culture period and the crosstalk between the two cell types was depicted. The viability, compact morphology and phenotypic stability of hepatocytes were enhanced in co‐cultures in comparison to monocultures. Gene expression of phase I and II enzymes was higher and CYP3A4 and CYP1A2 activity was inducible until week 2 of culture, being applicable for repeated‐dose toxicity testing. Moreover, the excretory activity was maintained in co‐cultures and the biosynthetic hepatocellular functions (albumin and urea secretion) were not affected by the presence of BM‐MSCs. This strategy might be extended to other hepatic cell sources and the characterization performed brings knowledge on the interplay between the two cell types, which may be relevant for therapeutic applications. Copyright © 2015 John Wiley & Sons, Ltd.
Comparison of Survival Models for Analyzing Prognostic Factors in Gastric Cancer Patients

Objective: There are a number of models for determining risk factors for survival of patients with gastric cancer. This study was conducted to select the model showing the best fit with available data. Methods: Cox regression and parametric models (Exponential, Weibull, Gompertz, Log normal, Log logistic and Generalized Gamma) were utilized in unadjusted and adjusted forms to detect factors influencing mortality of patients. Comparisons were made with Akaike Information Criterion (AIC) by using STATA 13 and R 3.1. 3 softwares. Results: The results of this study indicated that all parametric models outperform the Cox regression model. The Log normal, Log logistic and Generalized Gamma provided the best performance in terms of AIC values (179.2, 179.4 and 181.1, respectively). On unadjusted analysis, the results of the Cox regression and parametric models indicated stage, grade, largest diameter of metastatic nest, largest diameter of LM, number of involved lymph nodes and the largest ratio of metastatic nests to lymph nodes, to be variables influencing the survival of patients with gastric cancer. On adjusted analysis, according to the best model (log normal), grade was found as the significant variable. Conclusion: The results suggested that all parametric models outperform the Cox model. The log normal model provides the best fit and is a good substitute for Cox regression.
Perceived importance and difficulty of online activities among visually impaired persons in Nigeria

ABSTRACT This study investigated perceived relevance of and difficulties in access to day-to-day online activities among visually impaired computer users who used screen readers. The 98 participants in the study were grouped into visually impaired adults (aged 20–59, n = 60) and visually impaired older adults (aged 60 and over, n = 38). Data were collected in structured interview questionnaires with Likert scales exploring ratings of perceived importance and difficulty of access to 11 online platforms of various internet activities. Analyses revealed that the two groups did not differ significantly in ratings of perceived importance of four major online activities, namely sending or reading email (p = 0.5224), online banking (p = 0.2833), online shopping (p = 0.1829), and health information seeking (p = 0.1414). The topmost rated activity of priority among both groups was sending and reading emails. Findings also show that, apart from sending and reading emails, activities rated as important were mostly perceived as difficult to access. The implications of the study for inclusive design and strategies and/or interventions to encourage uptake of internet use among the visually impaired population are discussed.
Long Non-Coding RNAs Responsive to Salt and Boron Stress in the Hyper-Arid Lluteño Maize from Atacama Desert

Long non-coding RNAs (lncRNAs) have been defined as transcripts longer than 200 nucleotides, which lack significant protein coding potential and possess critical roles in diverse cellular processes. Long non-coding RNAs have recently been functionally characterized in plant stress–response mechanisms. In the present study, we perform a comprehensive identification of lncRNAs in response to combined stress induced by salinity and excess of boron in the Lluteño maize, a tolerant maize landrace from Atacama Desert, Chile. We use deep RNA sequencing to identify a set of 48,345 different lncRNAs, of which 28,012 (58.1%) are conserved with other maize (B73, Mo17 or Palomero), with the remaining 41.9% belonging to potentially Lluteño exclusive lncRNA transcripts. According to B73 maize reference genome sequence, most Lluteño lncRNAs correspond to intergenic transcripts. Interestingly, Lluteño lncRNAs presents an unusual overall higher expression compared to protein coding genes under exposure to stressed conditions. In total, we identified 1710 putatively responsive to the combined stressed conditions of salt and boron exposure. We also identified a set of 848 stress responsive potential trans natural antisense transcripts (trans-NAT) lncRNAs, which seems to be regulating genes associated with regulation of transcription, response to stress, response to abiotic stimulus and participating of the nicotianamine metabolic process. Reverse transcription-quantitative PCR (RT-qPCR) experiments were performed in a subset of lncRNAs, validating their existence and expression patterns. Our results suggest that a diverse set of maize lncRNAs from leaves and roots is responsive to combined salt and boron stress, being the first effort to identify lncRNAs from a maize landrace adapted to extreme conditions such as the Atacama Desert. The information generated is a starting point to understand the genomic adaptabilities suffered by this maize to surpass this extremely stressed environment.
Language Sampling for Preschoolers With Severe Speech Impairments.

Purpose The purposes of this investigation were to determine if measures such as mean length of utterance (MLU) and percentage of comprehensible words can be derived reliably from language samples of children with severe speech impairments and if such measures correlate with tools that measure constructs assumed to be related. Method Language samples of 15 preschoolers with severe speech impairments (but receptive language within normal limits) were transcribed independently by 2 transcribers. Nonparametric statistics were used to determine which measures, if any, could be transcribed reliably and to determine if correlations existed between language sample measures and standardized measures of speech, language, and cognition. Results Reliable measures were extracted from the majority of the language samples, including MLU in words, mean number of syllables per utterance, and percentage of comprehensible words. Language sample comprehensibility measures were correlated with a single word comprehensibility task. Also, language sample MLUs and mean length of the participants' 3 longest sentences from the MacArthur-Bates Communicative Development Inventory (Fenson et al., 2006) were correlated. Conclusion Language sampling, given certain modifications, may be used for some 3-to 5-year-old children with normal receptive language who have severe speech impairments to provide reliable expressive language and comprehensibility information.
An Improved Subspace-Based Optimization Method and Its Implementation in Solving Three-Dimensional Inverse Problems

This paper proposes an improved subspace-based optimization method (SOM) by using a new construction method for the ambiguous part of the induced current. The new current construction method reduces not only the computational complexity of the current construction in every iteration of the optimization but also the computational complexity of the singular-value decomposition of the mapping from the induced current to scattered fields. Thus, the improved SOM is able to deal with the 3-D inverse-scattering problems. Numerical tests validate the algorithm.
Moiré interferometry for engineering mechanics: Current practices and future developments

In the past decade, the optical method called moire interferometry has matured rapidly to emerge as an invaluable tool, proved by many industrial and scientific applications. It has been applied to numerous problems in engineering mechanics. It measures in-plane displacement fields with high sensitivity and high spatial resolution. This paper reviews current practices of moire interferometry and its extensions. Applications in diverse fields are addressed to demonstrate the wide applicability of the method, especially the recent applications for thermal deformation analyses of microelectronics devices. Speculation on future developments and practices is presented.
Mycobacterium tuberculosis Infection and Innate Responses in a New Model of Lung Alveolar Macrophages

Lung alveolar macrophages (AMs) are in the first line of immune defense against respiratory pathogens and play key roles in the pathogenesis of Mycobacterium tuberculosis (Mtb) in humans. Nevertheless, AMs are available only in limited amounts for in vitro studies, which hamper the detailed molecular understanding of host-Mtb interactions in these macrophages. The recent establishment of the self-renewing and primary Max Planck Institute (MPI) cells, functionally very close to lung AMs, opens unique opportunities for in vitro studies of host-pathogen interactions in respiratory diseases. Here, we investigated the suitability of MPI cells as a host cell system for Mtb infection. Bacterial, cellular, and innate immune features of MPI cells infected with Mtb were characterized. Live bacteria were readily internalized and efficiently replicated in MPI cells, similarly to primary murine macrophages and other cell lines. MPI cells were also suitable for the determination of anti-tuberculosis (TB) drug activity. The primary innate immune response of MPI cells to live Mtb showed significantly higher and earlier induction of the pro-inflammatory cytokines TNFα, interleukin 6 (IL-6), IL-1α, and IL-1β, as compared to stimulation with heat-killed (HK) bacteria. MPI cells previously showed a lack of induction of the anti-inflammatory cytokine IL-10 to a wide range of stimuli, including HK Mtb. By contrast, we show here that live Mtb is able to induce significant amounts of IL-10 in MPI cells. Autophagy experiments using light chain 3B immunostaining, as well as LysoTracker labeling of acidic vacuoles, demonstrated that MPI cells efficiently control killed Mtb by elimination through phagolysosomes. MPI cells were also able to accumulate lipid droplets in their cytoplasm following exposure to lipoproteins. Collectively, this study establishes the MPI cells as a relevant, versatile host cell model for TB research, allowing a deeper understanding of AMs functions in this pathology.
Design of a high reliability and low thermal resistance interface material for microelectronics

Thermal interface materials (TIMs) play a key role in the thermal management of microelectronic devices by providing a path of low thermal impedance between heat generating devices and heat dissipating components (heat spreader/sink). In addition, TIMs often provide mechanical coupling between the silicon device and the heat spreader/sink. During device operation, the adhesive joint between the heat generating device and heat spreader/sink is subjected to thermomechanical stresses due to differences in thermal expansion coefficients of the silicon device and the heat spreader material. The adhesive joint can consequently delaminate or debond from the mating surfaces causing a significant increase in thermal impedance across the thermal interface material. Hence, a TIM needs to offer improved thermal performance as well as enhanced reliability. In addition to these characteristics, several other requirements such as adhesion strength, response to different assembly parameters, and volatile content need to be considered and addressed during the development of a TIM. This paper discusses the development of such an interface material and a comprehensive performance evaluation of the new TIM.
Differences in transglutaminase mRNA after polyamine depletion in two cell lines.

Polyamines serve as natural substrates for the transglutaminase that catalyzes covalent cross-linking of proteins and is involved in cellular adhesion and proliferation. This study tests the hypothesis that intracellular polyamines play a role in the regulation of transglutaminase expression in rat small intestinal crypt cells (IEC-6 cell line) and human colon carcinoma cells (Caco-2 cell line). Treatment with α-difluoromethylornithine (DFMO; a specific inhibitor of polyamine synthesis) significantly depleted the cellular polyamines putrescine, spermidine, and spermine in both cell lines. In IEC-6 cells, polyamine depletion was associated with a decrease in the levels of transglutaminase mRNA. In Caco-2 cells, however, polyamine depletion significantly increased the levels of transglutaminase mRNA and enzyme activity. In both cell lines, ornithine decarboxylase mRNA levels increased and protooncogene c- myc mRNA decreased in the presence of DFMO. Addition of polyamines to cells treated with DFMO reversed the effect of DFMO on the levels of mRNA for these genes in both lines. There was no significant change in the stability of transglutaminase mRNA between control and DFMO-treated IEC-6 cells. In contrast, the half-life of mRNA for transglutaminase in Caco-2 cells was dramatically increased after polyamine depletion. Spermidine, when given together with DFMO, completely prevented increased half-life of transglutaminase mRNA in Caco-2 cells. These results indicate that 1) expression of transglutaminase requires polyamines in IEC-6 cells but is inhibited by these agents in Caco-2 cells, 2) polyamines modulate transglutaminase expression at the level of mRNA through different pathways in these two cell lines, and 3) posttranscriptional regulation plays a major role in the induction of transglutaminase mRNA in polyamine-deficient Caco-2 cells.
Analysis of 6,515 exomes reveals a recent origin of most human protein-coding variants

Establishing the age of each mutation segregating in contemporary human populations is important to fully understand our evolutionary history 1,2 and will help facilitate the development of new approaches for disease gene discovery 3 . Large-scale surveys of human genetic variation have reported signatures of recent explosive population growth 4-6 , notable for an excess of rare genetic variants, qualitatively suggesting that many mutations arose recently. To more quantitatively assess the distribution of mutation ages, we resequenced 15,336 genes in 6,515 individuals of European (n=4,298) and African (n=2,217) American ancestry and inferred the age of 1,146,401 autosomal single nucleotide variants (SNVs). We estimate that ~73% of all protein-coding SNVs and ~86% of SNVs predicted to be deleterious arose in the past 5,000-10,000 years. The average age of deleterious SNVs varied significantly across molecular pathways, and disease
Generative Modeling Using the Sliced Wasserstein Distance

Generative Adversarial Nets (GANs) are very successful at modeling distributions from given samples, even in the high-dimensional case. However, their formulation is also known to be hard to optimize and often not stable. While this is particularly true for early GAN formulations, there has been significant empirically motivated and theoretically founded progress to improve stability, for instance, by using the Wasserstein distance rather than the Jenson-Shannon divergence. Here, we consider an alternative formulation for generative modeling based on random projections which, in its simplest form, results in a single objective rather than a saddle-point formulation. By augmenting this approach with a discriminator we improve its accuracy. We found our approach to be significantly more stable compared to even the improved Wasserstein GAN. Further, unlike the traditional GAN loss, the loss formulated in our method is a good measure of the actual distance between the distributions and, for the first time for GAN training, we are able to show estimates for the same.