Miracle-dz/UniFAR-FTUs huggingface dataset:
Estimation of Seismic Earth Pressures Against Rigid Retaining Structures with Rotation Mode

The evaluation of seismic earth pressures is of vital importance for the earthquake resistant design of various retaining walls and infrastructures. It is one of the key research subjects in soil mechanics and geotechnical engineering. In engineering practices, the magnitude and distribution of seismic earth pressures are greatly affected by the mode and amount of wall displacement. However, classic Mononobe-Okabe solution can only compute the seismic earth pressures at the limit state and doesn't consider the effect of the mode and amount of wall movement on the seismic earth pressure. In this paper, the formation mechanism of earth pressures against rigid retaining wall with RTT and RBT mode is revealed based on the previous studies and a new method is proposed to calculate the seismic earth pressures in such conditions. Corresponding formula are derived and computer code is written to calculate the seismic earth pressure distribution based on the proposed methodology. Variation of seismic earth pressure coefficient for the rigid retaining wall with RTT and RBT mode is calculated and discussed. In addition, the effectiveness of the method is confirmed by the experimental results.
Treatment of Melanoma Brain Metastases: A New Paradigm

AbstractBrain metastases occur commonly in patients with metastatic melanoma, are associated with a poor prognosis, and cause significant morbidity. Both surgery and stereotactic radiosurgery are used to control brain metastases and, in selected patients, improve survival. In those with extensive brain involvement, whole-brain radiotherapy can alleviate symptoms. Historically, systemic therapy has had little role to play in the management of melanoma brain metastases; however, early clinical trials of BRAF inhibitors have shown promising activity. This review examines the evidence for local and systemic treatments in the management of patients with melanoma brain metastases. We present a new treatment algorithm for melanoma patients with brain metastases, which integrates the evolving evidence for the use of BRAF inhibitors.
Impact of P-Glycoprotein (ABCB1) and Breast Cancer Resistance Protein (ABCG2) Gene Dosage on Plasma Pharmacokinetics and Brain Accumulation of Dasatinib, Sorafenib, and Sunitinib

Low brain accumulation of anticancer drugs due to efflux transporters may limit chemotherapeutic efficacy, necessitating a better understanding of the underlying mechanisms. P-glycoprotein (Abcb1a/1b) and breast cancer resistance protein (Abcg2) combination knockout mice often display disproportionately increased brain accumulation of shared drug substrates compared with single transporter knockout mice. Recently developed pharmacokinetic models could explain this phenomenon. To experimentally test these models and their wider relevance for tyrosine kinase inhibitors and other drugs, we selected dasatinib, sorafenib, and sunitinib because of their divergent oral availability and brain accumulation profiles: the brain accumulation of dasatinib is mainly restricted by Abcb1, that of sorafenib mainly by Abcg2, and that of sunitinib equally by Abcb1 and Abcg2. We analyzed the effect of halving the efflux activity of these transporters at the blood-brain barrier by generating heterozygous Abcb1a/1b;Abcg2 knockout mice and testing the plasma and brain levels of the drugs after oral administration at 10 mg/kg. Real-time reverse transcription-polymerase chain reaction analysis confirmed the ∼2-fold decreased expression of both transporters in brain. Interestingly, whereas complete knockout of the transporters caused 24- to 36-fold increases in brain accumulation of the drugs, the heterozygous mice only displayed 1.6- to 1.9-fold increases of brain accumulation relative to wild-type mice. These results are well in line with the predictions of the pharmacokinetic models and provide strong support for their validity for a wider range of drugs. Moreover, retrospective analysis of fetal accumulation of drugs across the placenta in Abcb1a/1b heterozygous knockout pups suggests that these models equally apply to the maternal-fetal barrier.
Using Word Lattice Information for a Tighter Coupling in Speech Translation Systems

In this paper we present first experiments towards a tighter coupling between Automatic Speech Recognition (ASR) and Statistical Machine Translation (SMT) to improve the overall performance of our speech translation system. In coventional speech translation systems, the recognizer outputs a single hypothesis which is then translated by the SMT system. This approach has the limitation of being largely dependent on the word error rate of the first best hypothesis. The word error rate is typically lowered by generating many alternative hypotheses in the form of a word lattice. The information in the word lattice and the scores from the recognizer can be used by the translation system to obtain better performance. In our experiments, by switching from the single best hypotheses to word lattices as the interface between ASR and SMT, and by introducing weighted acoustic scores in the translation system, the overall performance was increased by 16.22%.
Modeling Deep Temporal Dependencies with Recurrent "Grammar Cells"

We propose modeling time series by representing the transformations that take a frame at time t to a frame at time t+1. To this end we show how a bi-linear model of transformations, such as a gated autoencoder, can be turned into a recurrent network, by training it to predict future frames from the current one and the inferred transformation using backprop-through-time. We also show how stacking multiple layers of gating units in a recurrent pyramid makes it possible to represent the "syntax" of complicated time series, and that it can outperform standard recurrent neural networks in terms of prediction accuracy on a variety of tasks.
Spatial Determinants of Land Prices in Auckland: Does the Metropolitan Urban Limit Have an Effect?

Land prices within monocentric cities typically decline from the centre to the urban periphery. More complex patterns are observed in polycentric and coastal cities; discrete jumps in value can occur across zoning boundaries. Information on these patterns within Auckland is important to understand: (a) the nature of Auckland's development, including the impact of infrastructure investments; and (b) the effects of regulation in causing discrete land valuation changes. One such regulation in Auckland is the metropolitan urban limit (MUL); we specifically examine whether the existence of this growth limit affects land prices. We do so in the context of a model of all Auckland land values over a twelve-year period, finding a strong zoning boundary effect on land prices.
A security framework for executables in a ubiquitous computing environment

The vision of ubiquitous computing presents us with unique difficulties in terms of maintaining security. Many of these relate to privacy or quality of service issues, but underpinning these is the requirement for secure execution of code. We present a novel framework for utilising a hybrid method of code analysis combined with component composition techniques. The aim has been to allow sandboxing techniques to maintain security dynamically in a ubiquitous computing environment. We argue that whilst security issues for ubiquitous computing are particularly acute, characteristics of the environment can also be harnessed advantageously to fulfil these security requirements.
Women's Personality, Work, and Retirement in the Mills Longitudinal Study

This dissertation examined links between Big Five personality measures and work lives in two studies of women in the Mills Longitudinal Study who worked substantially during mid-life (N=91). Study 1 investigated effects of personality on work: how did women who as college seniors scored high on Extraversion (E), Openness (O), and Conscientiousness (C) express these traits in their work lives throughout ascending, maintaining, and descending phases of work involvement from young adulthood to age 70? Personality did not predict either work or education variables in the early years after college (the early 1960s) when the culture was traditionally gender-typed and family-oriented. However, as women's roles changed, E, O, and C became generally and substantially related to work variables as expected from personality theory and research. Nonetheless, specific cultural influences (e.g., such as the link between C and the traditional women's role) affected the timing of involvement in work, and some of the women made personality-syntonic choices (e.g., in terms of nature of work and partners) that affected their financial security at age 70.The second study investigated effects of work on personality: how can early work experiences be conducive to subsequent personality change? This study related work satisfaction and status level of work to decreasing levels of Neuroticism over a period of middle age in which many Mills women were highly engaged in work. Consistent with past research, higher work satisfaction at age 43 predicted decreases in Neuroticism from 43 to 61--that is, the women showed a significant improvement in a broad domain of psychological functioning. As predicted, this positive and lasting effect of work satisfaction was mediated by the positive impact that their work experience had on the women's self-confidence. In contrast, occupational attainment per se was not associated with decrease in Neuroticism.Together, the two studies illustrate the mutually interactive relation between personality and work: early personality traits can importantly shape subsequent work lives (Study 1) but, in turn,early work experiences can shape subsequent personality development (Study 2).
Bmc Microbiology

Correlations of mutations in katG, oxyR-ahpC and inhA genes and in vitro susceptibility in Mycobacterium tuberculosis clinical strains segregated by spoligotype families from tuberculosis prevalent countries in South America Abstract Background: Mutations associated with resistance to rifampin or streptomycin have been reported for W/Beijing and Latin American Mediterranean (LAM) strain families of Mycobacterium tuberculosis. A few studies with limited sample sizes have separately evaluated mutations in katG, ahpC and inhA genes that are associated with isoniazid (INH) resistance. Increasing prevalence of INH resistance, especially in high tuberculosis (TB) prevalent countries is worsening the burden of TB control programs, since similar transmission rates are noted for INH susceptible and resistant M. tuberculosis strains.
Dynamic multi-path routing and how it compares with other dynamic routing algorithms for high speed wide area network

In this paper we describe briefly a dynamic multi-path routing scheme that has been considered for connection oriented homogeneous high speed networks. The fundamental objective of the scheme is to bridge the gap between routing and congestion control as the network becomes congested. Because propagation delay far out shadows queueing and transmission delay in high speed networks, the proposed routing scheme works as a shortest path (minimum hop) first algorithm under light traffic conditions. However as the shortest path becomes congested, the source node uses multiple paths when and if available in order to distribute the load and reduce packet loss. The scheme is a cross between Alternate Path routing and Trunk Reservation. We compare the performance of the proposed scheme with the Shortest Path Only algorithm, the Alternate Path routing algorithm, the Random Routing algorithm, and the Trunk Reservation scheme. The throughput and packet loss performance are compared via simulations. These have been carried out concentrating on a 5 node network with varying traffic patterns, the intention being to gain insight into the strengths and weaknesses of the various schemes.
Agroforestry Practices Promote Biodiversity and Natural Resource Diversity in Atlantic Nicaragua

Tropical forest conversion to pasture, which drives greenhouse gas emissions, soil degradation, and biodiversity loss, remains a pressing socio-ecological challenge. This problem has spurred increased interest in the potential of small-scale agroforestry systems to couple sustainable agriculture with biodiversity conservation, particularly in rapidly developing areas of the tropics. In addition to providing natural resources (i.e. food, medicine, lumber), agroforestry systems have the potential to maintain higher levels of biodiversity and greater biomass than lower diversity crop or pasture systems. Greater plant diversity may also enhance soil quality, further supporting agricultural productivity in nutrient-limited tropical systems. Yet, the nature of these relationships remains equivocal. To better understand how different land use strategies impact ecosystem services, we characterized the relationships between plant diversity (including species richness, phylogenetic diversity, and natural resource diversity), and soil quality within pasture, agroforests, and secondary forests, three common land use types maintained by small-scale farmers in the Pearl Lagoon Basin, Nicaragua. The area is undergoing accelerated globalization following the 2007 completion of the region’s first major road; a change which is expected to increase forest conversion for agriculture. However, farmer agrobiodiversity maintenance in the Basin was previously found to be positively correlated with affiliation to local agricultural NGOs through the maintenance of agroforestry systems, despite these farmers residing in the communities closest to the new road, highlighting the potential for maintaining diverse agroforestry agricultural strategies despite heightened globalization pressures. We found that agroforestry sites tended to have higher surface soil %C, %N, and pH relative to neighboring to secondary forest, while maintaining comparable plant diversity. In contrast, pasture reduced species richness, phylogenetic diversity, and natural resource diversity. No significant relationships were found between plant diversity and the soil properties assessed; however higher species richness and phylodiversity was positively correlated with natural resource diversity. These finding suggest that small, diversified agroforestry systems may be a viable strategy for promoting both social and ecological functions in eastern Nicaragua and other rapidly developing areas of the tropics.
The orientation-dependent visual spatial cut-off frequency in a spider

SUMMARY Cupiennius salei (Araneae, Ctenidae) has, like most spiders, eight camera-type eyes. The anterior median eyes are called principal eyes and have a movable retina; all of the other eyes are referred to as secondary eyes and are equipped with a reflecting tapetum. The photoreceptors in the secondary eyes are arranged in rows on the tapetum and the inter-receptor angle along such a row is smaller than normal to it. In this study, the vertical and horizontal spatial cut-off frequencies of moving gratings were measured for the posterior median (PM) eyes, and the data were then compared with the anatomical data reported in the literature. Detection of moving objects in the secondary eyes enhances the eye muscle potential frequency in the principal eyes. We thus recorded the eye muscle activity with a telemetric unit as a monitor for motion detection while moving stimuli – sinusoidally modulated bright and dark stripes – were presented to the PM eyes on a computer screen. A significant increase in the eye muscle activity was measured for gratings at an angular wavelength of 2.0 deg in the vertical orientation and of 2.7 deg in the horizontal direction. In the vertical orientation the critical wavelength is twice the inter-receptor angle; in the horizontal orientation the spiders responded to wavelengths that are smaller than twice the corresponding inter-receptor angle. The cut-off frequency seems thus to be limited by the visual field of the photoreceptors rather than the inter-receptor angle. The relative intensity modulations modelled for the two different grating orientations in single photoreceptor cells were in line with our data.
Photographs of manipulable objects are named more quickly than the same objects depicted as line-drawings: Evidence that photographs engage embodiment more than line-drawings

Previous research has shown that photographs of manipulable objects (i.e., those that can be grasped for use with one hand) are named more quickly than non-manipulable objects when they have been matched for object familiarity and age of acquisition. The current study tested the hypothesis that the amount of visual detail present in object depictions moderates these “manipulability” effects on object naming. The same objects were presented as photographs and line-drawings during a speeded naming task. Forty-six participants named 222 objects depicted in both formats. A significant object depiction (photographs versus line drawing) by manipulability interaction confirmed our hypothesis that manipulable objects are identified more quickly when shown as photographs; whereas, non-manipulable objects are identified equally quickly when shown as photographs versus line-drawings. These results indicate that factors such as surface detail and texture moderate the role of “action” and/or “manipulability” effects during object identification tasks, and suggest that photographs of manipulable objects are associated with more embodied representations of those objects than when they are depicted as line-drawings.
Pharmacokinetics and Safety of Intravenous and Oral Telmisartan 20 mg and 120 mg in Subjects with Hepatic Impairment Compared with Healthy Volunteers

The pharmacokinetics and safety of telmisartan were assessed in subjects with hepatic impairment in a single‐center, open‐label study. Single oral doses of telmisartan 20 mg and 120 mg, separated by a washout period of 14 days, were given to 12 hepatically impaired subjects and 12 healthy subjects. In 5 hepatically impaired subjects who received both oral doses, a single IV infusion of telmisartan 120 mg was later administered. After oral dosing, the pharmacokinetic profile of telmisartan was characterized by rapid absorption and disposition kinetics and a slow terminal elimination phase with mean half‐lives of 27 to 42 hours. The maximum plasma concentration and area under the telmisartan plasma concentration‐time curve (AUC0‐∞) increased in hepatically impaired subjects compared with healthy volunteers 6.4‐fold and 2.7‐fold, respectively, for telmisartan 20 mg and 3.2‐fold and 3.1‐fold, respectively, for telmisartan 120 mg. Maximum plasma concentrations and AUC0‐∞ after IV infusion were markedly elevated compared with values obtained from other studies conducted in healthy volunteers. Hepatic impairment resulted in an apparent increase in the absolute bioavailability of telmisartan, and total clearance following oral and IV administration was significantly reduced compared with healthy volunteers. Plasma protein binding of telmisartan was ≥ 99.5% in hepatically impaired and healthy subjects and was not changed when compared to healthy subjects. Oral and IV telmisartan were well tolerated in both the hepatically impaired and the healthy; headache was the most common potentially telmisartan‐related adverse event. Changes in vital signs and clinical laboratory parameters were transient and of no clinical relevance. The good tolerability of telmisartan in hepatically impaired patients demonstrated in this study, the proven sustained blood pressure control in hypertensive patients, and the increased exposure in patients with hepatic dysfunction suggest that effective treatment of hypertensive patients with impaired hepatic function would be achieved even with the lowest dose of telmisartan available. The increased bioavailability of telmisartan suggests that lower doses of telmisartan should be considered when the drug is administered to patients with hepatic impairment.
Energy-efficient concurrent testing approach for many-core systems in the dark silicon age

Dark Silicon issue stresses that a fraction of silicon chip being able to switch in a full frequency is dropping and designers will soon face a growing underutilization inherent in future technology scaling. On the other hand, by reducing the transistor sizes, susceptibility to internal defects increases and large range of defects such as aging or transient faults will be shown up more frequently. In this paper, we propose an online concurrent test scheduling approach for the fraction of chip that cannot be utilized due to the restricted utilization wall. Dynamic voltage and frequency scaling including near-threshold operation is utilized in order to maximize the concurrency of the online testing process under the constant power. As the dark area of the system is dynamic and reshapes at a runtime, our approach dynamically tests unused cores in a runtime to provided tested cores for upcoming application and hence enhance system reliability. Empirical results show that our proposed concurrent testing approach using dynamic voltage and frequency scaling (DVFS) improves the overall test throughput by over 250% compared to the state-of-the-art dark silicon aware online testing approaches under the same power budget.
Practicability of Hygienic Wrapping of Touchscreen Operated Mobile Devices in a Clinical Setting

Background To prove effectiveness of wrapping tablet computers in order to reduce microbiological contamination and to evaluate whether a plastic bag-covered tablet leads to impaired user satisfaction or touchscreen functionality. Materials and Methods Within a period of 11 days 115 patients were provided with a tablet computer while waiting for their magnetic resonance imaging examination. Every day the contamination of the surface of the tablet was determined before the first and after the final use. Before the device was handed over to a patient, it was enclosed in a customized single-use plastic bag, which was analyzed for bacterial contamination after each use. A questionnaire was applied to determine whether the plastic bag impairs the user satisfaction and the functionality of the touchscreen. Results Following the use by patients the outside of the plastic bags was found to be contaminated with various bacteria (657.5 ± 368.5 colony forming units/day); some of them were potentially pathogenic. In contrast, the plastic bag covered surface of the tablet was significantly less contaminated (1.7 ± 1.9 colony forming units/day). Likewise, unused plastic bags did not show any contamination. 11% of the patients reported problems with the functionality of the touchscreen. These patients admitted that they had never used a tablet or a smartphone before. Conclusions Tablets get severely contaminated during usage in a clinical setting. Wrapping with a customized single-use plastic bag significantly reduces microbiological contamination of the device, protects patients from the acquisition of potentially pathogenic bacteria and hardly impairs the user satisfaction and the functionality of the touchscreen.