Miracle-dz/UniFAR-FTUs huggingface dataset:
Bacteremia following tonsillectomy; effect of preoperative treatment with antibiotics in postoperative bacteremia and in bacterial content of tonsils.

This progress report on a clinical investigation was undertaken to throw light on the questions of: (1) the presence of a transient bacteremia after tonsillectomy that is similar to that observed after tooth extraction and its prevention by preoperative treatment with penicillin and other antibiotics, (2) the amount of information regarding the bacterial content of the deeper lymphoid tissue of the tonsils given by cultures from the surface of the throat, and (3) how antibiotic therapy affects the bacterial content of the deeper structures of the tonsil. METHOD Directly after the operation, while the patient was still in the operating room, blood was removed aseptically from the antecubital vein and added to Tryptose Phosphate broth and heart infusion agar for cultures of aerobic and anaerobic bacteria. Adequate penicillinase was added to the culture medium in the cases in which the subjects had been taking penicillin. Half the blood agar plates
Are U.S. Coral Reefs on the Slippery Slope to Slime?

Conservation of U.S. coral reefs has been sidetracked by the partial implementation of management plans without clearly achievable goals. Historical ecology reveals global patterns of coral reef degradation that provide a framework for reversing reef decline with ecologically meaningful metrics for success. The authors of this Policy Forum urge action now to address multiple threats simultaneously, because the harmful effects of stressors like overfishing, pollution, poor land-use practices, and global warming are interdependent. Prompt implementation of proven, practical solutions would lead to both short- and long-term benefits, including the return of keystone species and the economic benefits they entail.
Innovations in CT dose reduction strategy: application of the adaptive statistical iterative reconstruction algorithm.

OBJECTIVE The purpose of this article is to discuss the application of a new CT reconstruction algorithm, adaptive statistical iterative reconstruction (ASIR), to reduce radiation dose at body CT and to provide imaging examples in comparison with low-dose and standard-dose filtered back projection CT. CONCLUSION The ASIR reconstruction algorithm is a promising technique for providing diagnostic quality CT images at significantly reduced radiation doses.
Emotion and narrative fiction: Interactive influences before, during, and after reading

Emotions are central to the experience of literary narrative fiction. Affect and mood can influence what book people choose, based partly on whether their goal is to change or maintain their current emotional state. Once having chosen a book, the narrative itself acts to evoke and transform emotions, both directly through the events and characters depicted and through the cueing of emotionally valenced memories. Once evoked by the story, these emotions can in turn influence a person's experience of the narrative. Lastly, emotions experienced during reading may have consequences after closing the covers of a book. This article reviews the current state of empirical research for each of these stages, providing a snapshot of what is known about the interaction between emotions and literary narrative fiction. With this, we can begin to sketch the outlines of what remains to be discovered.
Medical ethics in peacetime and wartime: the case for a better understanding

Abstract Health-care workers face ethical dilemmas in their decision-making in every clinical intervention they make. In times of armed conflict the decisions may be different, and the circumstances can combine to raise ethical tensions. This article looks at the tensions in peacetime and in times of armed conflict and examines the types of cases that doctors and other health-care workers will face. It also discusses the common ethical decision-making framework and the role of communication within both clinical care and ethical analysis.
Studies on Genetic Male-Sterile Soybeans : II. Effect of Nodulation on Photosynthesis and Carbon Partitioning in Leaves.

Soybean (Glycine max L. Merr.) germplasm, essentially isogenic except for loci controlling male sterility (ms(1)) and nodulation (rj(1)), were developed to study the effects of reproductive development and nitrogen source on certain aspects of photosynthesis. Plants were sampled from flowering (77 days after transplanting) until maturity (150 days after transplanting). With all four genotypes, net carbon exchange rates were highest at flowering and declined thereafter. Photosynthetic rates of the sterile genotypes (nodulated and non-nodulated) declined more rapidly than the fertile genotypes, and after 105 days, both sterile genotypes maintained low but relatively constant carbon exchange rates (<3 milligrams CO(2)/gram fresh weight per hour). Photosynthetic rates and starch accumulation (difference between afternoon and morning levels) declined with time. The sterile genotypes attained the highest morning starch levels, which reflected reduced starch mobilization. After 92 days, the proportion of photosynthetically fixed carbon that was partitioning into starch (relative leaf starch accumulation) in the sterile genotypes increased dramatically. In contrast, relative leaf starch accumulation in the fertile genotypes remained relatively constant with time. Throughout the test period, all four genotypes maintained leaf sucrose levels between 5 and 15 micromoles glucose equivalents per gram fresh weight.The activities of sucrose phosphate synthase (SPS) in leaf extracts of the four genotypes declined from 77 to 147 days. Nodulated genotypes tended to maintain higher activities (leaf fresh weight basis) than did the non-nodulated genotypes. In general, relative leaf starch accumulation was correlated negatively with the activity of SPS (normalized with leaf net carbon exchange rate) in leaf extracts for all four genotypes during early reproductive development, and for the fertile genotypes at all sampling dates. In contrast, leaf sucrose content was correlated positively with SPS activity during early reproductive development. These results suggested that a direct relation existed between the activity of SPS and starch/sucrose levels in soybean leaves. However, the interaction between these processes also may be influenced by other factors, particularly when leaf photosynthetic rates and plant demand for assimilates is low, as in the sterile genotypes.
Novel Combinations of Synthesized ZnO NPs and Ceftazidime: Evaluation of their Activity against Standards and New Clinically Isolated Pseudomonas aeruginosa

Background: Antibiotic resistant bacteria can be considered as a main problem in infection management. Zinc oxide nanoparticles (ZnO NPs), individually or in combination with antibiotics, can be considered as good candidates for struggling against drug resistant bacteria. Methods: In this study, Zinc oxide nanoparticles were synthesized using sol-gel method in low temperature as a cost effective procedure and characterized by X-ray diffraction and Scanning Electron Microscopy. Antibacterial activity of 9 new combinations of Zinc oxide nanoparticles and ceftazidime was assessed against standards and new clinically isolated multi drug resistant Pseudomonas aeruginosa (P. aeruginosa), in order to evaluate enhancement effect of synthesized Zinc oxide nanoparticles on antibacterial activity of ceftazidime. Results: The results indicated that desirable effects can be seen at 6 and 7 mM of Zinc oxide nanoparticles (60 to 100% inhibition). Moreover, after evaluation of 9 new combinations with various concentrations of both components, it was demonstrated that Zinc oxide nanoparticles can enhance the antibacterial activity of ceftazidime, against some bacterial strains of P. aeruginosa. The highest activity was observed with the concentration of 20 μg/ml ceftazidime in the presence of 5, 6 or 7 mM of Zinc oxide nanoparticles. Conclusion: Zinc oxide nanoparticles in appropriate concentrations can be proposed as new and promising candidates for overcoming bacterial resistance.
Comparative evaluation of bite force analytical study following mandibular osteosysthesis using three-dimensional and conventional locking miniplates

Aims and Objectives: The aim is to study the effectiveness of 2 mm three-dimensional (3D) titanium miniplates and 2 mm conventional titanium miniplates in osteosynthesis of mandibular fractures by comparing the change in bite force. Methodology: The study comprised forty patients of age group 20–40 years, weighing 55–75 kg having mandibular fractures. Patients were randomly divided into two equal groups In Group A, twenty patients underwent osteosynthesis using 3D titanium miniplates (2.0 mm system), whereas in Group B, twenty patients underwent osteosynthesis using conventional titanium miniplates (2.0 mm system). After fixation of fracture segments with miniplates, the patients were assessed on the basis of evaluation of bite force at incisor, right molar and left molar region after 1, 3, 6 , and 8 weeks. Comparison of change in bite force was done between Group A and Group B at different follow-ups at incisor, right molar, and left molar. Results: Bite force recordings showed increasing values at subsequent follow-ups, corresponding to the healing of the fracture in both groups. At follow-up III (6 weeks) and IV (8 weeks), bite force values reached near to those in healthy individuals. A significant difference was observed in change in bite force of Group A and Group B at incisor left molar and right molar on subsequent followups. 3D titanium miniplate requires less surgical exposure of the underlying fracture site, with a minimal traction of the surrounding soft tissue. Interpretation and Conclusion: 3D miniplates in mandibular fractures are efficacious enough to bear masticatory loads during the osteosynthesis of fractures. It gives the advantage of greater stability, increased bite force, reduced implant material, and 3D stability.
The use of clozapine for the treatment of schizophrenia and implications for suicide prevention

Abstract Considerable progress has been made in the treatment of schizophrenia and other psychotic disorders ever since the discovery of chlorpromazine in the early 1950s and the subsequent discovery of the group of tricyclic chemical compounds including clozapine. On the spectrum of the contemporary pharmacological treatments for schizophrenia, atypical antipsychotic agents render a significant portion. Clozapine continues to play a pivotal role in the treatment of psychotic disorders, despite the emergence of new antipsychotic agents on the market. Among patients with schizophrenia, suicide is the main cause of death. Factors associated with suicide in patients with schizophrenia include previous suicide attempts, inadequate antipsychotic medication, non-compliance, substance abuse and non-response to antipsychotic medication. Clozapine reduces suicidal behavior in patients with schizophrenia. Clozapine has been shown to have a substantial effect on attempted suicide and completed suicide. The mode of action of clozapine in preventing suicide is not known. The various hypotheses proposed include its effects on neurotransmitters, on serum lipid levels, its antidepressant effects or the increased contact with healthcare workers during visits for blood monitoring.
Activity‐dependent modulation of the axonal conduction of action potentials along rat hippocampal mossy fibers

The axonal conduction of action potentials in the nervous system is generally considered to be a stable signal for the relaying of information, and its dysfunction is involved in impairment of cognitive function. Recent evidence suggests that the conduction properties and excitability of axons are more variable than traditionally thought. To investigate possible changes in the conduction of action potentials along axons in the central nervous system, we recorded action potentials from granule cells that were evoked and conducted antidromically along unmyelinated mossy fibers in the rat hippocampus. To evaluate changes in axons by eliminating any involvement of changes in the somata, two latency values were obtained by stimulating at two different positions and the latency difference between the action potentials was measured. A conditioning electrical stimulus of 20 pulses at 1 Hz increased the latency difference and this effect, which lasted for approximately 30 s, was inhibited by the application of an α‐amino‐3‐hydroxy‐5‐methylisoxazole‐4‐propionate (AMPA)/kainate receptor antagonist or a GluK1‐containing kainate receptor antagonist, but not by an AMPA receptor‐selective antagonist or an N‐methyl‐d‐aspartate receptor antagonist. These results indicated that axonal conduction in mossy fibers is modulated in an activity‐dependent manner through the activation of GluK1‐containing kainate receptors. These dynamic changes in axonal conduction may contribute to the physiology and pathophysiology of the brain.
A Robust and Scalable Constant-$g_m$  Rail-to-Rail CMOS Input Stage With Dynamic Feedback for VLSI Cell Libraries

In this paper, we propose a robust and scalable constant- rail-to-rail CMOS input stage for VLSI cell libraries. The proposed circuit does not rely on the characteristics and particular operation (strong, moderate, and weak inversion) regions of the input transistors and is insensitive to mismatches between p- and n-channel devices. Only standard CMOS transistors are used in the circuit without any special devices, such as floating-gate or depletion-mode transistors. Very small variations (less than ) have been achieved without sacrificing the large-signal behavior. The proposed circuit is proven effective for both long-channel and deep sub-micron CMOS technologies and is suitable for VLSI cell libraries, audio/video, embedded mixed-signal system-on-chip (SoC), and other applications. A prototype amplifier with rail-to-rail input common-mode range has been designed and fabricated in a standard 0.35-m CMOS technology. Experimental results confirm the effectiveness and robustness of proposed techniques.
Effects of local vanadium delivery on diabetic fracture healing

This study evaluated the effect of local vanadyl acetylacetonate (VAC), an insulin mimetic agent, upon the early and late parameters of fracture healing in rats using a standard femur fracture model. Mechanical testing, and radiographic scoring were performed, as well as histomorphometry, including percent bone, percent cartilage, and osteoclast numbers. Fractures treated with local 1.5 mg/kg VAC possessed significantly increased mechanical properties compared to controls at 6 weeks post‐fracture, including increased torque to failure (15%; p = 0.046), shear modulus (89%; p = 0.043), and shear stress (81%; p = 0.009). The radiographic scoring analysis showed increased cortical bridging at 4 weeks and 6 weeks (119%; p = 0.036 and 209%; p = 0.002) in 1.5 mg/kg VAC treated groups. Histomorphometry of the fracture callus at days 10 and 14 showed increased percent cartilage (121%; p = 0.009 and 45%; p = 0.035) and percent mineralized tissue (66%; p = 0.035 and 58%; p = 0.006) with local VAC treated groups compared to control. Additionally, fewer osteoclasts were observed in the local VAC treated animals as compared to controls at day 14 (0.45% ± 0.29% vs. 0.83% ± 0.36% of callus area; p = 0.032). The results suggest local administration of VAC acts to modulate osteoclast activity and increase percentage of early callus cartilage, ultimately enhancing mechanical properties comparably to non‐diabetic animals treated with local VAC. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:2174–2180, 2017.
The Effectiveness of a Technologically Facilitated Classroom-Based Early Reading Intervention

The purpose of this study was to evaluate the efficacy of a classroom-teacher-delivered reading intervention for struggling readers called the Targeted Reading Intervention (TRI), designed particularly for kindergarten and first-grade teachers and their struggling students in rural, low-wealth communities. The TRI was delivered via an innovative Web-conferencing system using laptop computers and webcam technology. Seven schools from the southwestern United States were randomly assigned to experimental and control conditions in a cluster randomized design. All children in the study (n = 364) were administered a battery of standardized reading skill tests in the fall and spring of the school year. Intent-to-treat analyses were conducted to estimate mixed models of children’s 1-year growth in Word Attack, Letter/Word Identification, Passage Comprehension, and Spelling of Sounds. Results showed that struggling readers from experimental schools outperformed those from control schools on all spring reading outcomes, controlling for fall scores.
Model Selection in Continuous Test Norming With GAMLSS

To compute norms from reference group test scores, continuous norming is preferred over traditional norming. A suitable continuous norming approach for continuous data is the use of the Box–Cox Power Exponential model, which is found in the generalized additive models for location, scale, and shape. Applying the Box–Cox Power Exponential model for test norming requires model selection, but it is unknown how well this can be done with an automatic selection procedure. In a simulation study, we compared the performance of two stepwise model selection procedures combined with four model-fit criteria (Akaike information criterion, Bayesian information criterion, generalized Akaike information criterion (3), cross-validation), varying data complexity, sampling design, and sample size in a fully crossed design. The new procedure combined with one of the generalized Akaike information criterion was the most efficient model selection procedure (i.e., required the smallest sample size). The advocated model selection procedure is illustrated with norming data of an intelligence test.
Expression profiling and functional analysis reveals that TOR is a key player in regulating photosynthesis and phytohormone signaling pathways in Arabidopsis

Target of rapamycin (TOR) acts as a master regulator to control cell growth by integrating nutrient, energy, and growth factors in all eukaryotic species. TOR plays an evolutionarily conserved role in regulating the transcription of genes associated with anabolic and catabolic processes in Arabidopsis, but little is known about the functions of TOR in photosynthesis and phytohormone signaling, which are unique features of plants. In this study, AZD8055 (AZD) was screened as the strongest active-site TOR inhibitor (asTORi) in Arabidopsis compared with TORIN1 and KU63794 (KU). Gene expression profiles were evaluated using RNA-seq after treating Arabidopsis seedlings with AZD. More than three-fold differentially expressed genes (DEGs) were identified in AZD-treated plants relative to rapamycin-treated plants in previous studies. Most of the DEGs and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways involved in cell wall elongation, ribosome biogenesis, and cell autophagy were common to both AZD- and rapamycin-treated samples, but AZD displayed much broader and more efficient inhibition of TOR compared with rapamycin. Importantly, the suppression of TOR by AZD resulted in remodeling of the expression profile of the genes associated with photosynthesis and various phytohormones, indicating that TOR plays a crucial role in modulating photosynthesis and phytohormone signaling in Arabidopsis. These newly identified DEGs expand the understanding of TOR signaling in plants. This study elucidates the novel functions of TOR in photosynthesis and phytohormone signaling and provides a platform to study the downstream targets of TOR in Arabidopsis.
PhD Students in the Entrepreneurial University - Perceived Support for Academic Entrepreneurship

Universities are currently in the process of change and adaptation to shifting expectations that for example include closer engagement with businesses and increased facilitation of entrepreneurship among faculty and graduates. By supporting academic entrepreneurship, universities can address these expectations whilst also becoming more entrepreneurial institutions. However, more knowledge is needed on how this support provided by different levels in the university organisation is perceived by academics. This is particularly relevant in the case of PhD students because many of them will go on to become the next generation of senior faculty and because PhD education constitutes a considerable part of most universities’ activities with PhD students performing a large share of university research. Our study is based on survey responses of 464 PhD students from all faculties at one of the biggest universities in Sweden. The results show that the perceived support of commercialisation of research results varies at different hierarchical levels within the university. The score for perceived support from the highest level (central administration) did not differ much between the faculties, while significant differences were found at lower levels. We argue that variations between faculties and departments with regard to norms and cultures should be considered when stimulating entrepreneurial engagement, for example by using multiple channels of communication, as well as tailor-made strategies and activities.
Phenotypical and genotypical characterization of Shewanella putrefaciens strains isolated from diseased freshwater fish.

Between 2007 and 2012, a variety of disease outbreaks most often characterized by skin disorders were observed among different species of freshwater fish in Poland. In most cases, the clinical signs included focally necrotized gills, necrotic skin lesions or ulcers. Internally, haemorrhages, oedematous kidney and abnormal spleen enlargement were generally noted. The disorders were accompanied by increased mortality. Most of the problems concerned cultured common carp Cyprinus carpio L. and rainbow trout Oncorhynchus mykiss (Walbaum). Fish have been examined from a number of these farms, and additionally, the wild and ornamental fish with similar clinical signs of diseases were also tested. Bacteria were isolated consistently from lesions and internal organs. They had characteristic orange-pigmented colonies which grew in pure culture or constituted 55-95% of total bacterial flora. One hundred and eighteen isolates were collected and biochemically identified as Shewanella putrefaciens group, and this was confirmed by sequencing. Challenge tests confirmed the pathogenicity of these bacteria. This is the first report characterizing and describing S. putrefaciens as a pathogen of different species of freshwater fish in Europe.