Miracle-dz/UniFAR-FTUs huggingface dataset:
Automatic transistor and physical design of FPGA tiles from an architectural specification

One of the most difficult and time-consuming steps in the creation of an FPGA is its transistor-level design and physical layout. Modern commercial FPGAs typically consume anywhere from 50 to 200 man-years simply in the layout step. To date, automated tools have only been employed in small parts of the periphery and programming circuitry. The core tiles, which are repeated many times, are subject to painstaking manual design and layout. In this paper we present a new system (called GILES, for Good Instant Layout of Erasable Semiconductors) that automatically generates a transistor-level schematic from a high-level architectural specification of an FPGA. It also generates a cell-level netlist that is placed and routed automatically. The architectural specification is the one used as input to the VPR [3] architectural exploration tool. The output is the mask-level layout of a single tile that can be replicated to form an FPGA array. We describe a new placement tool that simultaneously places and compacts the layout to minimize white space and wiring demand, and a special-purpose router built for this task.GILES can place and route a tile consisting of four 4-input LUT logic cells and all of its programmable wires in a 0. 18μm CMOS process using 8 layers of metal and 25983μm2 of area. When we generate the layout of an architecture similar to the Xilinx Virtex-E FPGA (built in a 0.18μm process) GILES requires only 47% more area than the original. The layout area of an architecture similar to the Altera Apex 20K400E (also built in a 0.18µm process) constructed by GILES requires 97% more area than the original.
Can Levothyroxine Be Taken as Evening Dose? Comparative Evaluation of Morning versus Evening Dose of Levothyroxine in Treatment of Hypothyroidism

152 drug naïve primary hypothyroid patients were divided into morning (Group 1) and evening (Group 2) dosing group and evaluated for change in biochemical profile, physical functioning and Quality of Life during the course of 12 weeks of study. At the end of 12 weeks 70 (90.90%) subjects in Group 1 and 72 (96%) in Group 2 achieved euthyroidism. On evaluation clinical symptoms and total clinical scores improved in both the groups at the end of 6 and 12 weeks. Significant improvement in thyroid profile was seen in both the groups at the end of 6 and 12 weeks (P value <.0001). On intergroup comparison, no significant difference in thyroid profile was seen at 6 and 12 weeks between the morning and the evening dose group. Similar dose of levothyroxine was required to achieve euthyroidism in both the groups. Though an early restoration of euthyroidism was seen in evening group, the difference when compared to the morning group was not statistically significant. On assessment of QoL, statistically significant improvement in various parameters was seen in both the groups. Hence, from the study we inferred that evening dose is as efficacious as morning dose and provides an alternate dosing regimen.
Interruptions and Distractions During Anesthesia Induction: A Pilot Study

Usually, the circulating registered nurse assists with anesthesia induction, but other personnel tend to interrupt the process to ask questions that are unrelated to the induction process. Interruptions and distractions can lead to loss of focus and result in medication errors if a certified registered nurse anesthetist (CRNA) swaps syringes during anesthesia induction. In this study, 8 CRNAs and cycles of anesthesia induction were observed, and the number of interruptions and distractions recorded. Results showed that most were from other personnel (M = 3 ± 0.53), conversation (M = 3 ± 1.19), and noise (M = 1.5 ± 1.3). With an average of 7.5 total interruptions per 9 min, these results indicate that CRNAs may experience 68 interruptions and distractions per hour. In another setting, this number is likely to be different. We have chosen to publish this provocative article to stimulate other similar studies of interruptions and distractions in the surgical setting. More research may show whether silence during induction is upheld as a safety measure, and what might be solutions to distractions and interruptions.
The p300 Acetylase Is Critical for Ligand-activated Farnesoid X Receptor (FXR) Induction of SHP*

The primary bile acid receptor farnesoid X receptor (FXR) maintains lipid and glucose homeostasis by regulating expression of numerous bile acid-responsive genes, including an orphan nuclear receptor and metabolic regulator SHP. Using SHP as a model gene, we studied how FXR activity is regulated by p300 acetylase. FXR interaction with p300 and their recruitment to the SHP promoter and acetylated histone levels at the promoter were increased by FXR agonists in mouse liver and HepG2 cells. In contrast, p300 recruitment and acetylated histones at the promoter were not detected in FXR-null mice. p300 directly interacted with and acetylated FXR in vitro. Overexpression of p300 wild type increased, whereas a catalytically inactive p300 mutant decreased, acetylated FXR levels and FXR transactivation in cells. While similar results were observed with a related acetylase, CBP, GCN5 did not enhance FXR transactivation, and its recruitment to the promoter was not increased by FXR agonists, suggesting functional specificity of acetylases in FXR signaling. Down-regulation of p300 by siRNA decreased acetylated FXR and acetylated histone levels, and occupancy of FXR at the promoter, resulting in substantial inhibition of SHP expression. These results indicate that p300 acts as a critical coactivator of FXR induction of SHP by acetylating histones at the promoter and FXR itself. Surprisingly, p300 down-regulation altered expression of other metabolic FXR target genes involved in lipoprotein and glucose metabolism, such that beneficial lipid and glucose profiles would be expected. These unexpected findings suggest that inhibition of hepatic p300 activity may be beneficial for treating metabolic diseases.
Correlation between Intake of Dietary Fiber and Adherence to the Korean National Dietary Guidelines in Adolescents from Jeonju

This study surveyed dietary intake and adherence to the Korean national dietary guidelines in Korean adolescents. To elucidate basic data for use in nutrition education, which aims to improve adolescent compliance with the national dietary guidelines and to increase the intake of dietary fiber, we evaluated the sources of fiber in adolescent diets. This study included 182 male and 212 female students from 2 middle schools in the Jeonju province. From November 15~20, 2011, we surveyed the students for general characteristics, adherence to the Korean national dietary guidelines, and dietary intake. Dietary fiber intake was 16.57 ± 6.95 g/day for male students and 16.14 ± 7.11 g/day for female students. The food groups that contributed most to dietary fiber intake were (in descending order) cereals, vegetables, seasoning, and fruits. The fiber-containing food items consumed most were cabbage- kimchi, cooked rice, instant noodles, and cabbage. Based on adherence to the Korean national dietary guidelines, the vegetable-based intake of dietary fiber in groups 1 (score 15~45), 2 (score 46~52), and 3 (score 53~75) were 4.41 ± 2.595 g/day, 4.12 ± 2.692 g/day, and 5.49 ± 3.157 g/day, respectively (p<0.001). In addition, the total intake of dietary fiber varied significantly among the three groups (p<0.001) as follows: Group 1, 14.99 ± 6.374 g/day; Group 2, 15.32 ± 6.772 g/day; and Group 3, 18.79 ± 7.361 g/day. In this study, we discovered that adherence to the Korean national dietary guidelines correlates with improved intake of dietary fiber. Therefore, marketing and educational development is needed to promote adherence to the Korean national dietary guidelines. In addition, nutritional education is needed to improve dietary fiber consumption through the intake of vegetables and fruits other than kimchi.
Characterization of Protein Hubs by Inferring Interacting Motifs from Protein Interactions

The characterization of protein interactions is essential for understanding biological systems. While genome-scale methods are available for identifying interacting proteins, they do not pinpoint the interacting motifs (e.g., a domain, sequence segments, a binding site, or a set of residues). Here, we develop and apply a method for delineating the interacting motifs of hub proteins (i.e., highly connected proteins). The method relies on the observation that proteins with common interaction partners tend to interact with these partners through a common interacting motif. The sole input for the method are binary protein interactions; neither sequence nor structure information is needed. The approach is evaluated by comparing the inferred interacting motifs with domain families defined for 368 proteins in the Structural Classification of Proteins (SCOP). The positive predictive value of the method for detecting proteins with common SCOP families is 75% at sensitivity of 10%. Most of the inferred interacting motifs were significantly associated with sequence patterns, which could be responsible for the common interactions. We find that yeast hubs with multiple interacting motifs are more likely to be essential than hubs with one or two interacting motifs, thus rationalizing the previously observed correlation between essentiality and the number of interacting partners of a protein. We also find that yeast hubs with multiple interacting motifs evolve slower than the average protein, contrary to the hubs with one or two interacting motifs. The proposed method will help us discover unknown interacting motifs and provide biological insights about protein hubs and their roles in interaction networks.
Application of mechanism-based CYP inhibition for predicting drug–drug interactions

Background: A mechanism-based inhibition of CYPs is characterized by NADPH-, time- and concentration-dependent enzyme inactivation and substrate protection. A significant inactivation of CYPs and particularly the main human hepatic and intestinal CYPs could result in clinical drug–drug interactions (DDIs) and adverse drug reactions. Objective: To address whether DDIs owing to mechanism-based CYP inhibition is predictable based on in vitro inhibitory data. Method: Medline (by means of PubMed up to 26 March 2009) has been searched using proper relevant terms. Result/conclusion: It is possible to predict DDIs caused by mechanism-based CYP inhibition, although the in vitro data do not necessarily translate directly into relative extents of inhibition in vivo because in vivo clinical consequences depend on additional factors that are not easily accounted for in vitro and for reversible inhibition. Incorporation of other important parameters such as CYP degradation rate (kdeg), relative contribution of the CYP inactivated to the victim drug elimination (fm(CYP)) and inhibition of intestinal CYP-mediated first-pass metabolism of the object drug (F'gut/Fgut ratio) into the prediction models significantly improves the prediction. Uncertainty of the prediction is mainly from the variability in the estimates of these critical parameters.
Consumption of 2 and 4 egg yolks/d for 5 wk increases macular pigment concentrations in older adults with low macular pigment taking cholesterol-lowering statins.

BACKGROUND Lutein and zeaxanthin may reduce the risk of dry, age-related macular degeneration because of their photo-oxidative role as macular pigment. OBJECTIVE The present study evaluated serum lutein, zeaxanthin, and macular pigment optical density (MPOD) responses at 0.25 degrees , 0.5 degrees , and 1 degree retinal eccentricities to the consumption of 2 and 4 egg yolks/d by older adults taking cholesterol-lowering medications. DESIGN Subjects consumed foods containing 2 followed by 4 egg yolks/d for 5 wk each with a 4-wk egg-free period at baseline and between the 2 interventions. RESULTS Changes in MPOD (n = 37) with egg yolk consumption were inversely associated (P < 0.05) with baseline MPOD. Subjects with low-baseline MPOD (defined as MPOD < or =0.5 at 0.25 degrees , < or =0.4 at 0.5 degrees , and < or =0.35 at 1 degrees ) showed increases of < or =50% (P < 0.05) with 4 egg yolks at the 3 retinal eccentricities. MPOD increased by 31% (P = 0.059) at 0.5 degrees with 2 egg yolks. Serum lutein increased by only 16% and 24% (P < 0.05) compared with increases of 36% and 82% (P < 0.001) in serum zeaxanthin (n = 52) after consumption of 2 and 4 egg yolks, respectively. Serum HDL cholesterol increased by 5% (P < 0.05) after consumption of 2 and 4 egg yolks. Serum LDL cholesterol did not change with either egg yolk treatment. CONCLUSIONS Consumption of 4 egg yolks/d, and possibly of 2 egg yolks/d, for 5 wk benefited macular health in older adults with low MPOD. Serum HDL cholesterol increased without an increase in LDL cholesterol in this study population, most of whom were taking cholesterol-lowering statins.
Crouch gait can be an effective form of forced-use/no constraint exercise for the paretic lower limb in stroke

In hemiplegic gait the paretic lower limb provides less muscle power and shows a briefer stance compared with the unaffected limb. Yet, a longer stance and a higher power can be obtained from the paretic lower limb if gait speed is increased. This supports the existence of a ‘learned non-use’ phenomenon, similar to that underlying some asymmetric impairments of the motion of the eyes and of the upper limbs. Crouch gait (CG) (bent-hip bent-knee, about 30° minimum knee flexion) might be an effective form of ‘forced-use’ treatment of the paretic lower limb. It is not known whether it also stimulates a more symmetric muscle power output. Gait analysis on a force treadmill was carried out in 12 healthy adults and seven hemiplegic patients (1–127 months after stroke, median: 1.6). Speed was imposed at 0.3 m/s. Step length and single and double stance times, sagittal joint rotations, peak positive power, and work in extension of the hip, knee, and ankle (plantar flexion), and surface electromyography (sEMG) area from extensor muscles during the generation of power were measured on either side during both erect and crouch walking. Significance was set at P less than 0.05; corrections for multiplicity were applied. Patients, compared with healthy controls, adopted in both gait modalities and on both sides a shorter step length (61–84%) as well as a shorter stance (76–90%) and swing (63–83%) time. As a rule, they also provided a higher muscular work (median: 137%, range: 77–250%) paralleled by a greater sEMG area (median: 174%, range: 75–185%). In erect gait, the generation of peak extensor power across hip, knee, and ankle joints was in general lower (83–90%) from the paretic limb and higher (98–165%) from the unaffected limb compared with control values. In CG, peak power generation across the three lower limb joints was invariably higher in hemiparetic patients: 107–177% from the paretic limb and 114–231% from the unaffected limb. When gait shifted from erect to crouch, only for hemiplegic patients, at the hip, the paretic/unaffected ratio increased significantly. For peak power, work, sEMG area, and joint rotation, the paretic/unaffected ratio increased from 55 to 85%, 56 to 72%, 68 to 91%, and 67 to 93%, respectively. CG appears to be an effective form of forced-use exercise eliciting more power and work from the paretic lower limb muscles sustained by a greater neural drive. It also seems effective in forcing a more symmetric power and work from the hip extensor muscles, but neither from the knee nor the ankle.
Simulation of cold-test characteristics for TWT slow-wave structures

A method has been established to accurately calculate cold-test data for helical slow-wave structures using the three-dimensional (3D) electromagnetic computer code MAFIA [Kory, 1996]. Compared with the experiment data, absolute average differences across the bandwidth of 0.2% and 3.4 Ohms for the dispersion and impedance, respectively. The computer code MAFIA is also used in this analysis to determine the effect on dispersion and on-axis interaction impedance of the wedge support rod geometry parameter variation.
Illuminating the Role for Chloride Dysregulation in Network Activity

Commentary Perturbation in GABAergic inhibition is often a prominent feature of epilepsies, and treatments aimed at enhancing GABA currents are part of the standard clinical arsenal to stop seizures. Apart from loss of interneurons, functional deficits in inhibition are also known to occur in epilepsy (1). GABAmediated inhibition in the mammalian brain largely depends on the Chloride ion (Cl) gradient (2). Gradient driven influx of negatively charged Cl into the cell hyperpolarizes the cell membrane, thereby driving the membrane away from the threshold for action potential generation. Physiologically, homeostasis of Cl is maintained by cation-chloride cotransporters (CCC) NKCC1 and KCC2, which regulate Cl influx and efflux. Dysregulation of CCCs leads to intracellular accumulation of Cl and a positive shift in GABA reversal potential (EGABA). Interestingly, dysregulation of NKCC1 and KCC2 have been observed in human temporal lobe epilepsy and in animal models (3–6). However, whether such a reversal in the polarity of GABA alone would be sufficient to initiate seizures is still not clear. The study by Alfonsa and coworkers is aimed at answering this question. Alfonsa and coworkers make novel use of optogenetic technology, which involves expression of light-activated channels or transporters to control neuronal activity, to manipulate Cl levels in cortical pyramidal neurons. Activation of halorhodopsin (NpHR) by amber light induces membrane hyperpolarization by transporting Cl into the cell. The intracellular chloride load, deemed an unfortunate side effect due to its potential impact on GABA currents, spearheaded the development of Archaerhodopsin (Arch), which extrudes protons on light activation without altering chloride homeostasis (7). The authors have brilliantly used halorhodopsin and Arch to address the role of intracellular Cl dysregulation in seizure induction. They effectively distinguish between effects of hyperpolarization, which is common to both opsins, from those due to the Cl dysregulation, which is unique to halorhodopsin. Using this strategy together with electrical and chemical activation of slices and computational modeling, the authors examine how enhancing intracellular Cl impacts network rhythms and seizure generation. Using perforated patch recordings, which prevent exchange of chloride from recording solution to the cell, the authors first determine the magnitude and duration of shift in EGABA following light activation in cultured cortical The Contribution of Raised Intraneuronal Chloride to Epileptic Network Activity.
Potential GPRS 900/180-MHz and WCDMA 1900-MHz Interference to Medical Devices

This study compared the potential for interference to medical devices from radio frequency (RF) fields radiated by GSM 900/1800-MHz, general packet radio service (GPRS) 900/1800-MHz, and wideband code division multiple access (WCDMA) 1900-MHz handsets. The study used a balanced half-wave dipole antenna, which was energized with a signal at the standard power level for each technology, and then brought towards the medical device while noting the distance at which interference became apparent. Additional testing was performed with signals that comply with the requirements of the international immunity standard to RF fields, IEC 61000-4-3. The testing provides a sense of the overall interference impact that GPRS and WCDMA (frequency division duplex) may have, relative to current mobile technologies, and to the internationally recognized standard for radiated RF immunity. Ten medical devices were tested: two pulse oximeters, a blood pressure monitor, a patient monitor, a humidifier, three models of cardiac defibrillator, and two models of infusion pump. Our conclusion from this and a related study on consumer devices is that WCDMA handsets are unlikely to be a significant interference threat to medical electronics at typical separation distances.
A Diffusion Tensor Imaging Study in Children With ADHD, Autism Spectrum Disorder, OCD, and Matched Controls: Distinct and Non-Distinct White Matter Disruption and Dimensional Brain-Behavior Relationships.

OBJECTIVE Neurodevelopmental disorders (NDDs) (attention deficit hyperactivity disorder [ADHD], autism spectrum disorder [ASD], and obsessive-compulsive disorder [OCD]) share genetic vulnerability and symptom domains. The authors present direct comparison of structural brain circuitry in children and adolescents with NDDs and control subjects and examine brain circuit-behavior relationships across NDDs using dimensional measures related to each disorder. METHOD Diffusion imaging and behavioral measures were acquired in 200 children and adolescents (ADHD: N=31; OCD: N=36; ASD: N=71; controls: N=62; mean age range: 10.3-12.6 years). Following Tract-Based Spatial Statistics, multigroup comparison of white matter indices was conducted, followed by pairwise comparisons. Relationships of fractional anisotropy with dimensional measures of inattention, social deficits, obsessive-compulsive symptoms, and general adaptive functioning were conducted across the NDD sample. RESULTS Lower fractional anisotropy within the splenium of the corpus callosum was found in each NDD group, compared with the control group. Lower fractional anisotropy in additional white matter tracts was found in the ASD and ADHD groups, compared with the control group, but not in the OCD group. Fractional anisotropy was lower in the ASD and ADHD groups compared with the OCD group but was not different in ADHD participants compared with ASD participants. A positive relation between fractional anisotropy (across much of the brain) and general adaptive functioning across NDDs was shown. CONCLUSIONS This study identified disruption in interhemispheric circuitry (i.e., fractional anisotropy alterations in the corpus callosum) as a shared feature of ASD, ADHD, and OCD. However, fractional anisotropy alterations may be more widespread and severe in ASD and ADHD than in OCD. Higher fractional anisotropy throughout the brain appears to be related to better adaptive function across NDDs.
Antioxidants for prevention of preterm delivery.

Introduction Preterm delivery is the major cause of infant morbidity and mortality in developed countries. Although many patients deliver prematurely secondary to preterm labor, a significant portion of preterm births can be attributed to delivery that is indicated for maternal or fetal problems. The problem of preterm delivery can therefore be indirectly addressed by attempting to ameliorate maternal conditions that result in indicated preterm delivery. In this chapter, we will address the pathophysiology underlying 2 important causes of preterm delivery— pre-eclampsia and preterm premature rupture of membranes—and examine the role of oxidative stress and thus the rationale for treatment with antioxidants.