Miracle-dz/UniFAR-FTUs huggingface dataset:
( MICTs ) for clinical work practices ? A review of selected pilot studies What ’ s so different about mobile information communication technologies

can be found at: Health Informatics Journal Additional services and information for http://jhi.sagepub. com/cgi/alerts Email Alerts: http://jhi.sagepub. com/subscriptions Subscriptions: http://www.sagepub. com/journalsReprints.nav Reprints: http://www.sagepub. com/journalsPermissions.nav Permissions: http://jhi.sagepub. com/cgi/content/refs/11/2/123 SAGE Journals Online and HighWire Press platforms): (this article cites 14 articles hosted on the Citations
Ieee Transactions on Information Forensics and Security Security of Lattice-based Data Hiding against the Known Message Attack

Security of Quantization Index Modulation (QIM) watermarking methods is usually sought through a pseudorandom dither signal which randomizes the codebook. This dither plays the role of the secret key, i.e. a parameter only shared by the watermarking embedder and decoder, which prevents unauthorized embedding and/or decoding. However, if the same dither signal is reused, the observation of several watermarked signals can provide sufficient information for an attacker to estimate the dither signal. This paper focuses on the cases when the embedded messages are either known or constant. In the first part of this paper, a theoretical security analysis of QIM data hiding measures the information leakage about the secret dither as the mutual information between the dither and the watermarked signals. In the second part, we show how set-membership estimation techniques successfully provide accurate estimates of the dither from observed watermarked signals. The conclusion of this twofold study is that current QIM watermarking schemes have a relative low security level against this scenario because a small number of observed watermarked signals yield a sufficiently accurate estimate of the secret dither. The analysis presented in this paper also serves as the basis for more involved scenarios.
EVIDENCE BASED PUBLIC HEALTH POLICY AND PRACTICE Evaluation of the quality of cause of death statistics in rural China using verbal autopsies

Background: Death registration systems in rural China are in a developmental stage. The Disease Surveillance Points (DSP) system provides the only nationally representative information on causes of death. In this system, there are no standard procedures or instruments for ascertaining causes of death; hence available statistics require careful evaluation before use. Aim: To assess the reliability of data from the DSP. Methods: 14 DSP sites were selected through stratified sampling, enrolling 2482 deaths registered during June–November 2002. Defined verbal autopsy (VA) procedures were used to derive underlying causes of death. k Measures of agreement between VA and registered diagnoses were computed. VA diagnoses were used as references to compute sensitivity and positive predictive values. Finally, patterns of cause-specific discordance between the two data sources were studied. Results: k Scores indicate only moderate agreement for chronic obstructive pulmonary disease (COPD) and ischaemic heart disease (IHD). The results also suggest that COPD is undercounted in registration data. A significant degree of cross attribution of cause was found between the two data sources. Overall, the VA was successful in limiting deaths with ill-defined causes to ,10%. Conclusions: Diagnoses based on structured symptom questionnaires in the VA approach seem plausible and reliable as compared with lay-reported diagnoses in registration data. Concerns with attribution of cause of death due to COPD, IHD and tuberculosis in registration data suggest caution in their use for research and health programme purposes. The VA methods tested in this study offer promise for implementation in the routine registration system.
Evaluating Usability and Efficaciousness of an E-learning System: A Quantitative, Model-Driven Approach

Using an e-learning system as a case example of complex information systems, we tested a conceptual framework that expands upon the Technology Acceptance Model (TAM) and incorporate measures of self-efficacy. A survey instrument was developed to gather large samples of users' perceptions on system usability and usefulness. Advanced statistical tests such as structural equation modeling were carried out. The paper concludes with a discussion on efficacy of evaluation techniques and design implications for e-learning systems.
Primary cells in BCR/FGFR1‐positive 8p11 myeloproliferative syndrome are sensitive to dovitinib, ponatinib, and dasatinib

Translocations involving the fibroblast growth factor receptor 1 (FGFR1) gene are associated with the 8p11 myeloproliferative syndrome (EMS), a rare neoplasm that following a usually short chronic phase progresses into acute myeloid or lymphoid leukemia. The treatment commonly involves chemotherapy and, if possible, allogeneic stem cell transplantation which is the only therapeutic option for long‐term survival. Given the aggressive course of EMS, we here evaluated tyrosine kinase inhibitors as treatment options to delay disease progression.
Lateral Intraparietal Cortex and Reinforcement Learning during a Mixed-Strategy Game

Activity of the neurons in the lateral intraparietal cortex (LIP) displays a mixture of sensory, motor, and memory signals. Moreover, they often encode signals reflecting the accumulation of sensory evidence that certain eye movements might lead to a desirable outcome. However, when the environment changes dynamically, animals are also required to combine the information about its previously chosen actions and their outcomes appropriately to update continually the desirabilities of alternative actions. Here, we investigated whether LIP neurons encoded signals necessary to update an animal's decision-making strategies adaptively during a computer-simulated matching-pennies game. Using a reinforcement learning algorithm, we estimated the value functions that best predicted the animal's choices on a trial-by-trial basis. We found that, immediately before the animal revealed its choice, ∼18% of LIP neurons changed their activity according to the difference in the value functions for the two targets. In addition, a somewhat higher fraction of LIP neurons displayed signals related to the sum of the value functions, which might correspond to the state value function or an average rate of reward used as a reference point. Similar to the neurons in the prefrontal cortex, many LIP neurons also encoded the signals related to the animal's previous choices. Thus, the posterior parietal cortex might be a part of the network that provides the substrate for forming appropriate associations between actions and outcomes.
Modeling evolutionary landscapes: mutational stability, topology, and superfunnels in sequence space.

Random mutations under neutral or near-neutral conditions are studied by considering plausible evolutionary trajectories on "neutral nets"-i.e., collections of sequences (genotypes) interconnected via single-point mutations encoding for the same ground-state structure (phenotype). We use simple exact lattice models for the mapping between sequence and conformational spaces. Densities of states based on model intrachain interactions are determined by exhaustive conformational enumeration. We compare results from two very different interaction schemes to ascertain robustness of the conclusions. In both models, sequences in a majority of neutral nets center around a single "prototype sequence" of maximum mutational stability, tolerating the largest number of neutral mutations. General analytical considerations show that these topologies by themselves lead to higher steady-state evolutionary populations at prototype sequences. On average, native thermodynamic stability increases toward a maximum at the prototype sequence, resulting in funnel-like arrangements of native stabilities in sequence space. These observations offer a unified perspective on sequence design, native stability, and mutational stability of proteins. These principles are generalizable from native stability to any measure of fitness provided that its variation with respect to mutations is essentially smooth.
The TFIID subunit TAF4 regulates keratinocyte proliferation and has cell-autonomous and non-cell-autonomous tumour suppressor activity in mouse epidermis

The TAF4 subunit of transcription factor TFIID was inactivated in the basal keratinocytes of foetal and adult mouse epidermis. Loss of TAF4 in the foetal epidermis results in reduced expression of the genes required for skin barrier function, leading to early neonatal death. By contrast, TAF4 inactivation in adult epidermis leads to extensive fur loss and an aberrant hair cycle characterised by a defective anagen phase. Although the mutant epidermis contains few normal anagen-phase hair follicles, many genes expressed at this stage are strongly upregulated indicating desynchronised and inappropriate gene expression. The TAF4 mutant adult epidermis also displays interfollicular hyperplasia associated with a potent upregulation of several members of the EGF family of mitogens. Moreover, loss of TAF4 leads to malignant transformation of chemically induced papillomas and the appearance of invasive melanocytic tumours. Together, our results show that TAF4 is an important regulator of keratinocyte proliferation and has cell-autonomous and non-cell-autonomous tumour suppressor activity.
Correlation of hyperglycemia with mortality after acute ischemic stroke

Background: Hyperglycemia has been considered a predictor of stroke outcomes. In this article we study the correlation between blood glucose levels within the first 24 h after stroke onset and patients’ outcomes in mortality and hemorrhagic transformations. Methods: Ninety-one non-diabetic patients with acute ischemic stroke admitted to a neurological intensive unit were recruited. Their blood glucose was measured twice within 6 h (baseline) and at every hour after stroke onset. Patients were collected into four groups as follows: those in which normoglycemia and no hyperglycemia were observed at either baseline or 24 h; those with baseline hyperglycemia and hyperglycemia only at baseline; those with 24 h hyperglycemia and hyperglycemia only at 24 h after stroke; and those with persistent hyperglycemia and hyperglycemia at both baseline and at 24 h. Endpoints were designated as the patient’s death within 30 days and/or hemorrhagic transformation under computerized tomography within the first 7 days after stroke onset. Results: Persistent hyperglycemia was correlated with an increased risk of mortality within 30 days (OR = 24.0; 95% CI = 2.8–199.3) and it was also correlated with hemorrhagic transformation (OR = 13.3; 95% CI = 2.7–66.1). Baseline or delayed hyperglycemia were not correlated with any outcome. Conclusions: Persistent hyperglycemia was correlated with mortality after acute ischemic stroke.
Personal models of diabetes in relation to self-care, well-being, and glycemic control. A prospective study in adolescence.

OBJECTIVE Personal models of diabetes have been shown to be proximal determinants of self-care behavior in adults with diabetes, both cross-sectionally and prospectively. This study set out to test the predictive utility of this approach in adolescents with diabetes. RESEARCH DESIGN AND METHODS Participants were recruited from four regional hospitals in southern England (n = 54). They completed questionnaires assessing diabetes self-care, well-being, and personal models of diabetes (perceived impact, perceived seriousness, and short- and long-term treatment effectiveness) at baseline and 1-year follow-up. GHb assays performed as part of the patients' usual diabetes care were used to assess glycemic control. RESULTS After controlling for baseline anxiety, change in perceived impact of diabetes prospectively predicted adolescents' anxiety (beta = -0.21; t = -2.65; P < 0.01). After controlling for baseline dietary self-care, change in perceived effectiveness of the diabetes treatment regimen to control diabetes predicted dietary self-care (beta = -0.39; t = -3.28; P < 0.0005). Poorer dietary self-care and being female were predictive of poorer glycemic control (r2 = 0.29; F = 2.74; P < 0.005). CONCLUSIONS This study provides further support for the role of personal models of illness in determining responses to illness. As adolescents take responsibility for the management of their diabetes, parents, clinicians, educators, and interventionists should consider these adolescents' beliefs about their diabetes and its treatment as key factors influencing self-care, emotional well-being. and glycemic control.
Structure and function of endogenous feline leukemia virus long terminal repeats and adjoining regions

The nucleotide sequence of the 5' long terminal repeat (LTR) of three independent loci (CFE-6, CFE-16, and CF-14) of endogenous feline leukemia virus (FeLV) DNAs of the domestic cat genome was determined. The 3' LTR of the CFE-6 clone was also sequenced. The endogenous FeLV LTRs, which were very similar to each other in sequence and in organization of the functional domains, differed considerably from the exogenous FeLV LTR in the U3 region. The major differences in U3 included variations in sets of small (14 to 19 base pair) direct repeats, altered location of the simian virus 40 core enhancer-like sequence, and occurrence of three segments of largely nonhomologous sequences. There was extensive homology between endogenous and exogenous FeLV LTRs in sequences beginning from the TATA box through the R region down to the 3' end of the U5 region. The DNA sequence downstream of the 5' LTR encompassing the primer-binding site, leader, and almost to the end of the p15gag coding region, a point up to which the sequencing was carried out, also revealed a high degree of conservation. However, the detection of frameshift and nonsense mutations in this region of a nearly full-length endogenous provirus sequence (CFE-6) predicted its defectiveness and correlated with the lack of infectivity of this DNA. The functional studies of the endogenous LTRs, based on linkage to the bacterial cat gene and transient expression in feline cell lines, indicated that although the basic characteristics for promotion and enhancement of transcription were retained in each LTR, there was a significant variation in the activity of the cat constructs. Reconstruction and deletion analyses with the CFE-6 5' LTR revealed the presence of strong transcription regulatory sequences in the 702-base-pair region immediately upstream of the 5' boundary of the endogenous LTR. These and related data suggest that in addition to the transcription-modulating elements occurring within the LTR, the cis-acting nucleotide sequences in the upstream cellular DNA may determine the overall efficiency of transcription of the defective endogenous FeLV provirus loci of the felid genome.
Teens Who Hurt: Clinical Interventions to Break the Cycle of Adolescent Violence

Introduction. Part I: The Model. Adolescent Violence in a Sociocultural Context. Devaluation. Disruption of Community. The Dehumanization of Loss. Rage. Part II: Strategies. Adolescent Axioms. Counteracting Devaluation. Restoration of Community. Rehumanizing Loss. Rechanneling Rage. Final Reflections.
Morphologic characteristics of periprosthetic tissues from hip prostheses with ceramic-ceramic couples: A comparative histologic investigation of 18 revision and 30 autopsy cases

Pseudocapsules and interface membranes from 18 revision cases having hip prostheses with ceramic-ceramic couples and 30 autopsy specimens (6 with ceramic-ceramic couples, 7 with ceramic-polyethylene combinations and 17 with metal-polyethylene combinations) were histomorphologically analyzed, including a semiquantitative grading of the wear particles and histologic changes. Unlike the revision cases, which usually showed ceramic wear particles in the adjacent tissues, only half of the autopsy cases revealed ceramic wear. As compared to the ceramic-polyethylene and metal-polyethylene couples, the alumina on alumina combinations showed a thinner synovial layer with reduced villous transformation and smaller infiltrates of macrophages and necroses, which can be explained by the absence of polyethylene wear. Metal-polyethylene couplings produced more than twice as many polyethylene wear particles with correspondingly more marked foreign body reaction than the ceramic-polyethylene couplings.
Generalization with Precision: The Role of Negative Teaching Examples in the Instruction of Generalized Grocery Item Selection

For generalization to be functional, it must occur with a precision that results in acquired responses occurring under appropriate, nontrained conditions, and acquired responses not occurring under inappropriate, nontrained conditions. This study examines the effect of differing types of negative teaching examples on the precision with which generalized grocery item selection is learned. Within a split-multiple baseline design, six young adults identified as mildly, moderately, or severely mentally retarded were trained to select or to reject grocery items using picture cards as cues. The dependent variables were correct selection of 10 trained “positive” grocery items and the correct rejection of 20 nontrained “negative” grocery items in a nontrained grocery store. Participants were trained in a grocery store to select 10 positive grocery examples matching their picture cards and to reject either (a) a set of negative examples that were maximally different from the positive examples, or (b) a set of negative examples that were minimally different from the positive examples. Both training sets resulted in participants correctly selecting the 10 positive items in a nontrained store. Training with the “minimally different” negative examples was functionally related to improved rejection of nontrained negative items in the nontrained store. The implications of teaching with minimally different, negative examples are discussed.
Psychophysical Stress of Arm Motions at Varying External Load and Repetition

This study aims to investigate effect of external load and motion repetitiveness on perceived discomfort. An experiment was performed for measuring discomfort scores at varying conditions, in which external load, motion repetitiveness and arm posture were employed as experimental variables. The arm posture was controlled by shoulder flexion and abduction, and by elbow flexion. Fifteen healthy college-age students without history of musculoskeletal disorders voluntarily participated in the experiment. The results showed that the effect of external load, motion repetitiveness and shoulder posture on discomfort were statistically significant, but that elbow posture did not significantly affect discomfort ratings. The effect of external load was much larger than that of any other variables, and that of repetitiveness was second only to external load. Discomfort scores significantly increased linearly as the levels of external load and motion repetitiveness increased. This implies that although they were not fully reflected in the existing posture classification scheme such as OWAS, RULA, etc., the effect of external load and motion repetitiveness should be taken into consideration for precisely quantifying work load in industry. Based on regression analysis, equivalent values of external load and motion repetitiveness in terms of discomfort scores were provided, which would be useful for better understanding the degree of their effect on work load.
Introducing the `gay gene': media and scientific representations

In 1993 a paper in the prestigious scientific journal Science announced the discovery of a linkage between genetics and male homosexuality. The linkage was promptly dubbed the `gay gene' by the media, and the paper was widely reported. This article examines the reporting of the `gay gene' in the British press and television news, and compares it with commentary in scientific journals. The article focuses on the representation of homosexuality and the representation of science. It considers the charges levelled at the media by some critics and finds many of them wanting. Finally, it concludes with some comments about the public understanding of science and the need for the scientific understanding of the media and the public.
Synchronization Error Estimation and Controller Design for Delayed Lur'e Systems With Parameter Mismatches

This paper investigates the problem of master-slave synchronization of two delayed Lur'e systems in the presence of parameter mismatches. First, by analyzing the corresponding synchronization error system, synchronization with an error level, which is referred to as quasi-synchronization, is established. Some delay-dependent quasi-synchronization criteria are derived. An estimation of the synchronization error bound is given, and an explicit expression of error levels is obtained. Second, sufficient conditions on the existence of feedback controllers under a predetermined error level are provided. The controller gains are obtained by solving a set of linear matrix inequalities. Finally, a delayed Chua's circuit is chosen to illustrate the effectiveness of the derived results.
Simulation studies of multiple dipole neuromagnetic source localization: model order and limits of source resolution

Numerical simulation studies were performed using a multiple-dipole source model and a spherical approximation of the head to determine how the resolution of simultaneously active neuromagnetic sources depends on source modeling assumptions (i.e., number of assumed dipoles), actual source parameters (e.g., location, orientation, and moment), and measurement errors. Forward calculations were made for a series of source configurations in which the number of dipoles, specific dipole parameters, and noise levels were systematically varied. Simulated noisy field distributions were fit by multiple dipole models of increasing model order (1,2, . . ., 6), and alternative statistical approaches (i.e., percent of variance, reduced chi-square, and F-ratio) were compared for their effectiveness in determining adequate model order. Limits of spatial resolution were established for a variety of multisource configurations and noise conditions. Implications for the analysis of empirical data are discussed. <<ETX>>