Miracle-dz/UniFAR-FTUs huggingface dataset:
Prognostic Significance of Defective Mismatch Repair and BRAF V600E in Patients with Colon Cancer

Purpose: Colon tumors with defective DNA mismatch repair (dMMR) have a well-characterized phenotype and accounts for ∼15% to 20% of sporadic colon cancer as well as those colon cancer patients with Lynch syndrome. Although the presence of dMMR seems to be a favorable prognostic marker, data suggest that these patients do not respond as well to adjuvant chemotherapy. Experimental Design: In this study, we examined the prognostic significance of tumor MMR deficiency and the presence of a specific mutation in BRAF (V600E) in a group of patients (n = 533) who participated in a randomized prospective clinical trial through the North Central Cancer Treatment Group. Results: Tumors with dMMR were found to be associated with higher tumor grade (P = 0.001), proximal location (P < 0.0001), and improved overall and disease-free survival (P = 0.05 and 0.04, respectively). Among all cases examined, evaluation of the BRAF V600E mutation status revealed no statistically significant differences in either disease-free or overall survival. Patients were then grouped into four categories for further analysis: dMMR/BRAF(−), dMMR/BRAF(+), pMMR/BRAF(−), and pMMR/BRAF(+). The dMMR/BRAF(−) group had a significantly improved overall survival (5-year overall survival of 100% versus 73%, P = 0.002) compared with all others. The remaining three groups had very similar survival outcomes. An additional cohort of tumors previously classified as having dMMR were also tested for the BRAF V600E alteration. Results remained significant (P = 0.006) when the two groups were combined for analysis. Conclusions: Overall, these data suggest that the underlying molecular etiology of those tumors having dMMR may influence the disease outcome in these patients.
Stroke Prevention in Patients With Atrial Fibrillation: Disease Burden and Unmet Medical Needs

Abstract The incidence of atrial fibrillation (AF), as well as the related morbidity and mortality, is increasing in step with the aging of the US population. Frequently, AF leads to untoward outcomes, including a 5-fold increased risk of stroke, hospitalization, impaired quality of life, and decreased work productivity. Therapeutic decision making for patients with AF at risk for stroke is a process that varies from one physician to the next. This lack of consistency in care is compounded by disrupted communication among caregivers coupled with barriers to health care resources. Improved application of evidence-based treatment guidelines for the diagnosis, staging, and tracking of AF-associated stroke is needed, especially because patients with AF are at high risk. In addition to affecting practice guidelines, the latest anticoagulants are poised to change the standard of care for preventing stroke in patients with AF. These novel agents, with their greater safety and ease of administration, have the potential to improve treatment outcomes.
Attention, Need for Sensation, and Health Communication Campaigns

Although attention to novelty is no longer as vital to survival as in our ancient past, the attention value of novelty has major implications for contemporary human communication. It also is affected by individual differences in reactivity to intense and novel stimulation. The studies reported in this article involve the roles of attention and sensation seeking in responses to drug abuse prevention campaigns in the mass media. Early studies have indicated that adolescent high-sensation seekers are two to seven times more likely to report using drugs—ranging from alcohol to cocaine—than lower sensation seekers, identifying them as prime target audiences for prevention campaigns. This article describes a series of studies, ranging from laboratory studies on differential effects of messages on high- and low-sensation seekers, and on effects of program context, to a field experiment in which high-sensation seekers were targeted.
Moderating and Mediating Effects of Social Support in the Relationship between Work-family Conflict, Job Satisfaction and Turnover Intention among Married Women Nurses

Purpose: The purpose of this study was to identify moderating and mediating effects of social support in the relationship between work-family conflict, job satisfaction and turnover intention among married women nurses. Methods: The sample for this study consisted of 225 married female nurses from two hospitals located in Seoul. Data were collected through structured questionnaires and analyzed using descriptive statistics, t-test, ANOVA, Pearson correlation coefficients and hierarchical multiple regression with the SPSS 21.0 program. Results: (a) Social support of married female nurses had significant moderating and mediating effects between work-family conflict and job satisfaction. (b) Social support of married female nurses had significant moderating and mediating effects between work-family conflict and turnover intention. Conclusion: The results of the study indicate that social support is an important factor in work-family conflict, job satisfaction and turnover intention among married female nurses. Supervisor support is important to married nurses as social support as it is controlled by the organization. Therefore, supportive relationships based on mutual respect between supervisors and nurses are necessary for a creative organizational atmosphere and system.
CD44+/CD24− phenotype predicts a poor prognosis in triple-negative breast cancer

Cancer stem cells are enriched in triple-negative breast cancer (TNBC) tumor tissues, which present strong capacities of proliferation and tumorigenicity. The present study detected the distribution of cancer stem cell markers cluster of differentiation (CD)44/CD24 and analyzed the clinical outcomes of different CD44/CD24 phenotypes in patients with TNBC. Multivariate Cox regression analyses were performed with regard to the prognostic value of cancer stem cell markers CD44/CD24, aldehyde dehydrogenase 1 and other baseline clinical characteristics, including tumor size, lymph node involved, adjuvant chemotherapy, Ki-67, breast cancer susceptibility gene 1, cellular tumor antigen p53, vimentin and basal-like status. The multivariate analyses showed that three of these factors, CD44/CD24 phenotype, basal-like status and number of lymph nodes involved, had an impact on overall survival. Furthermore, patients with CD44+/CD24− phenotype, basal-like tumors and ≥4 lymph nodes involved had a significantly worse prognosis. The expression of CD44 and CD24 was detected by double-staining immunohistochemistry, which can locate cancer stem cells individually. Overall, the present results indicated that CD44/CD24 status evaluated by double-staining immunohistochemistry constitutes an independent prognostic factor for TNBC.
Psychosocial Processes Associated with Bullying and Victimization

Bullying and victimization are timely, robust areas of inquiry throughout various psychological paradigms. Humanistic psychology has a history of investigating victimized individuals, but unfortunately, as this review of the literature demonstrates, the Humanistic voice has not remained active in these investigations. I contend that by exploring the research of these behaviors, Humanistic researchers may identify areas in need of Humanistic-oriented inquiries. This discussion explores the relevant literature focused on psychosocial processes associated with bullying and victimization. Also reviewed are individual characteristic variables, developmental trajectories of both bullies and victims, the role of social cognitive processes, social status and power, social networks, and bully and victim psychopathological trajectories.
Diversity-Based Reasoning in Children

One of the hallmarks of inductive reasoning by adults is the diversity effect, namely that people draw stronger inferences from a diverse set of evidence than from a more homogenous set of evidence. However, past developmental work has not found consistent diversity effects with children age 9 and younger. We report robust sensitivity to diversity in children as young as 5, using everyday stimuli such as pictures of objects with people. Experiment 1 showed the basic diversity effect in 5- to 9-year-olds. Experiment 2 showed that, like adults, children restrict their use of diversity information when making inferences about remote categories. Experiment 3 used other stimulus sets to overcome an alternate explanation in terms of sample size rather than diversity effects. Finally, Experiment 4 showed that children more readily draw on diversity when reasoning about objects and their relations with people than when reasoning about objects' internal, hidden properties, thus partially explaining the negative findings of previous work. Relations to cross-cultural work and models of induction are discussed.
Coronally advanced flap combined with a subepithelial connective tissue graft using full- or partial-thickness flap reflection.

BACKGROUND Although the use of a subepithelial connective tissue graft (SCTG) in conjunction with a coronally advanced flap (CAF) is a widely performed periodontal procedure, the creation of a partial-thickness flap can incur a risk of perforation or overthinning of the flap itself. Therefore, the aim of the present trial is to compare the efficacies of partial- and full-thickness flap reflections combined with an SCTG. METHODS Twenty patients with Miller Class I or II defects (52 teeth) were selected, and teeth with defects were randomly assigned to the test group (25 teeth) for a CAF and SCTG using a full-thickness flap reflection or to the control group (27 teeth) for a CAF associated with an SCTG and partial-thickness flap reflection. The probing depth (PD), gingival recession (GR), and width of the keratinized tissue (KT) were assessed at baseline and 6 months after surgery. RESULTS The mean root coverage was 97% in the test group (mean reduction in GR: 2.27 ± 1.15 mm) and 95% in the control group (mean reduction in GR: 1.68 ± 0.74 mm). The gain in KT was 0.46 ± 1.47 mm in the test group and 0.49 ± 1.3 mm in the control group, the PD ranged from 1.33 to 1.55 mm in the test group and from 1.31 to 1.64 mm in the control group; no statistically significant difference was found between the two groups for all of these parameters (P >0.05). CONCLUSIONS The elevation of a full- or partial-thickness flap did not appear to influence the amount of KT or the percentage of root coverage achieved post-surgically. More expanded studies are needed to confirm the present findings.
Why Do Social Work Students Engage in Lesbian and Gay Rights Activism?

This paper considers the contexts and motivations as to why some social work students engage in lesbian and gay rights activism. To explain electoral and protesting modes of activism, this study utilized variables from resource, mobilizing, and framing theories of political participation to explain activism related to gay and lesbian rights. After gathering data on 159 undergraduate social work majors, regressions suggest that economic resources failed to explain participation in gay and lesbian politics. Instead, the predictors of gay and lesbian activism more closely aligned with four key variables: educational attainment, communicating with full-fledged activists, having an ability to recognize heterosexism, and maintaining a commitment to social justice.
The Pathophysiology of Migraine

BACKGROUND—Migraine results from episodic changes in central nervous system physiologic function in hyperexcitable brain manifested by abnormal energy metabolism, lowered threshold for phosphene generation, and increased contingent negative variation. Human functional magnetic resonance imaging and magnetoencepholography data strongly suggest that aura is caused by cortical spreading depression. REVIEW SUMMARY–Brain hyperexcitability may be caused by low magnesium levels, mitochondrial abnormalities with abnormal phosphorylation of adenosine 5’-diphosphate, a dysfunction related to nitric oxide, or calcium channelopathy. Low magnesium can result in opening of calcium channels, increased intracellular calcium, glutamate release, and increased extracellular potassium, which may in turn trigger cortical spreading depression. Mitochondrial dysfunction has been suggested by a low phosphocreatine:Pi ratio and a possible response by migraine patients to riboflavin prophylaxis. Nitroglycerine administration results in a delayed migraine-like headache in migraine patients but not in control patients, and a nonspecific nitric oxide synthase inhibitor aborted migraine at 2 hours in the majority of tested migraine patients compared to controls. Many patients with familial hemiplegic migraine have a missense mutation in the P/Q calcium channel, so that this form of migraine, at least, is associated with a demonstrable calcium channelopathy. CONCLUSIONS–The generation of migraine occurs centrally in the brain stem, sometimes preceded by cortical spreading depression and aura. Activation of the trigeminovascular system stimulates perivascular trigeminal sensory afferent nerves with release of vasoactive neuropeptides, resulting in vasodilation and transduction of central nociceptive information. There is then a relay of pain impulses to central second- and third-order neurons and activation of brain stem autonomic nuclei to induce associated symptoms.
The effect of forage source and particle size on finishing yearling steer performance and ruminal metabolism.

Two finishing trials and a metabolism trial were conducted to evaluate the effect of forage source and particle size in dry-rolled corn finishing diets. In Exp. 1, 224 crossbred yearling steers (BW = 342+/-11 kg) were used in a randomized complete block design consisting of seven treatments. Treatments were an all-concentrate diet or diets containing equal NDF levels provided by alfalfa hay or wheat straw (three treatments each) with each forage source ground to pass through a . 95-, 7.6-, or 12.7-cm screen. Steers fed diets containing forage had greater (P < .05) DMI than steers fed an all-concentrate diet. Steers fed alfalfa diets gained faster (P < .05) with a greater (P < .05) concentrate efficiency than steers fed either all-concentrate or straw diets. In Exp. 2, 120 crossbred yearling steers (BW = 307+/-2 kg) were used in a completely randomized design and fed dry-rolled corn diets containing 10% alfalfa ground to pass through either a . 95- or 7.6-cm screen. Alfalfa particle size had no effect on performance or carcass measurements. In Exp. 3, six ruminally fistulated steers (BW = 508+/-34 kg) were used in a 6 x 6 Latin square design and fed an all-concentrate diet or diets containing equal NDF levels provided by alfalfa hay, wheat straw, or ground corncobs with alfalfa and straw ground to pass through either a 2.54- or 12.7-cm screen. Steers fed straw diets spent more time (P < .10) chewing than those receiving the other diets. In conclusion, forage particle size had no effect on finishing cattle performance or ruminal metabolism data. However, cattle consuming different forage sources in dry-rolled corn finishing diets may not respond similarly in animal performance.
Lactobacilli and Bifidobacteria in Human Breast Milk: Influence of Antibiotherapy and Other Host and Clinical Factors

Objective: The objective of this work was to study the lactobacilli and bifidobacteria population in human milk of healthy women, and to investigate the influence that several factors (including antibioteraphy during pregnancy and lactation, country and date of birth, delivery mode, or infant age) may exert on such population. Methods: A total of 160 women living in Germany or Austria provided the breast milk samples. Initially, 66 samples were randomly selected and cultured on MRS-Cys agar plates. Then, the presence of DNA from the genera Lactobacillus and Bifidobacterium, and from most of the Lactobacillus and Bifidobacterium species that were isolated, was assessed by qualitative polymerase chain reaction (PCR) using genus- and species-specific primers. Results: Lactobacilli and bifidobacteria could be isolated from the milk of 27 (40.91%) and 7 (10.61%), respectively, of the 66 cultured samples. On the contrary, Lactobacillus and Bifidobacterium sequences were detected by PCR in 108 (67.50%) and 41 (25.62%), respectively, of the 160 samples analyzed. The Lactobacillus species most frequently isolated and detected was L salivarius (35.00%), followed by L fermentum (25.00%) and L gasseri (21.88%), whereas B breve (13.75%) was the bifidobacterial species most commonly recovered and whose DNA was most regularly found. The number of lactobacilli- or bifidobacteria-positive samples was significantly lower in women who had received antibiotherapy during pregnancy or lactation. Conclusions: Our results suggest that either the presence of lactobacilli and/or bifidobacteria or their DNA may constitute good markers of a healthy human milk microbiota that has not been altered by the use of antibiotics.
Probing the Active Site Loop Motif of Murine Ferrochelatase by Random Mutagenesis*

Ferrochelatase catalyzes the terminal step of the heme biosynthetic pathway by inserting ferrous iron into protoporphyrin IX. A conserved loop motif was shown to form part of the active site and contact the bound porphyrin by molecular dynamics calculations and structural analysis. We applied a random mutagenesis approach and steady-state kinetic analysis to assess the role of the loop motif in murine ferrochelatase function, particularly with respect to porphyrin interaction. Functional substitutions in the 10 consecutive loop positions Gln248–Leu257 were identified by genetic complementation in Escherichia coli strain Δvis. Lys250, Val251, Pro253, Val254, and Pro255 tolerated a variety of replacements including single substitutions and contained low informational content. Gln248, Ser249, Gly252, Trp256, and Leu257 possessed high informational content, since permissible replacements were limited and only observed in multiply substituted mutants. Selected active loop variants exhibited kcat values comparable with or higher than that of wild-type murine ferrochelatase. The Km values for porphyrin increased, except for the single mutant V251L. Other than a moderate increase observed in the triple mutant S249A/K250Q/V251C, the Km values for Fe2+ were lowered. The kcat/Km for porphyrin remained largely unchanged, with the exception of a 10-fold reduction in the triple mutant K250M/V251L/W256Y. The kcat/Km for Fe2+ was improved. Molecular modeling of these active loop variants indicated that loop mutations resulted in alterations of the active site architecture. However, despite the plasticity of the loop primary structure, the relative spatial positioning of the loop in the active site appeared to be maintained in functional variants, supporting a role for the loop in ferrochelatase function.
The significance of individuals' dispositions in workplace learning: a case study of two teachers

This article about workplace learning examines the relationship between, firstly, individual learners positions and dispositions, and secondly, their working and learning within the workplace community and practices. Drawing on research with secondary school teachers, it presents case study accounts of two teachers from the same school to illustrate the significance of these relationships. In order to understand these relationships from a broadly participatory perspective, the article then presents a theoretical discussion, extending Lave and Wenger's work on communities of practice, through the use of Bourdieu's concepts of habitus, capital and field. It concludes that such a combination offers a valuable means of understanding these relationships, in a wider social, economic and political context. It is necessary to offer an account of learning for work which acknowledges the independence of individuals acting within the interdependence of the social practice of work. (Billett, 2001, p. 22)
The use of amisulpride in the treatment of acute psychosis

The management of acute episodes in schizophrenia is frequently initiated in the psychiatric emergency department and requires rapid intervention to relieve distress and psychiatric symptoms. Both non-pharmacological and pharmacological interventions are needed to calm the patient and prevent potential harm to the patient or others. Treatment is a step-by-step process including management of behavioral symptomatology, diagnosis of potential organic causes, and evaluation of potential substance abuse. Better care is delivered if predefined standard operating procedures are adopted systematically. The ultimate goal of treatment is to establish a therapeutic alliance with the patient. Atypical antipsychotics given orally are recommended as a first-line treatment. As the treatment endpoint is calmness rather than sleep, a non-sedative antipsychotic agent is usually preferred. Drug tolerance is a major issue for the patient. Amisulpride is an effective atypical antipsychotic agent in this context. The optimal dose is 800 mg/day, which is effective on positive and negative symptoms and can be given from the first day with a low risk of extrapyramidal symptoms. Since drug–drug interactions are limited, agitation and anxiety may be controlled by short-term adjunctive therapy with benzodiazepines. In conclusion, amisulpride is an appropriate first-line treatment for the management of acute psychosis.
Injuries caused by pets in Asian urban households: a cross-sectional telephone survey

Objectives Little is known about pet-related injuries in Asian populations. This study primarily aimed to investigate the incidence rate of pet-related household injuries in Hong Kong, an urban Chinese setting. Setting Cantonese-speaking non-institutionalised population of all ages in Hong Kong accessible by telephone land-line. Participants A total of 43 542 telephone numbers were dialled and 6570 residents successfully completed the interviews. Primary and secondary outcome measures Data of pet-related household injuries in the previous 12 months, pet ownership and socio-demographic characteristics were collected with a questionnaire. Direct standardisation of the incidence rates of pet-related household injuries by gender and age to the 2009 Hong Kong Population Census was estimated. Univariate and multivariate analyses were performed to estimate risks of socio-demographic factors and pet ownership for the injury. Results A total of 84 participants experienced pet-related household injuries in the past 12 months, with an overall person-based incidence rate of 1.28%. The majority of the victims were injured once (69.6%). Cats (51.6%) were the most common pets involved. Pet owners were at an extremely higher risk after controlling for other factors (adjusted OR: 52.0, 95% CI 22.1 to 98.7). Females, the unmarried, those with higher monthly household income and those living in lower-density housing were more likely to be injured by pets. Conclusions We project a pet-related household injury incidence rate of 1.24% in the general Hong Kong population, with 86 334 residents sustaining pet-related injuries every year. Pet ownership puts people at extremely high risk, especially the unmarried. Further studies should focus on educating pet owners to reduce pet-related injuries in urban Greater China.
Costs and rewards in barbershop singing

Barbershop singing is a hobbyist form of serious leisure which, like other hobbies and amateur pursuits, has its own pattern of costs and rewards that is characteristic of the activity. To discover this pattern, observations were made of the principal activities of four male and female barbershop chapters in Calgary and interviews undertaken with 32 of their members. The object of the larger study was to develop a grounded theory of barbershop singing as serious leisure using a qualitative-exploratory research design. That part of the study reported here deals with the rewards and thrills of barbershop, which are compared with its costs: the disappointments, dislikes, and tensions. Overall, barbershop singers find a substantial ‘profit’ after weighing these positives and negatives, which indicates that, in their hobby, the bitter is well-offset by the sweet.