Miracle-dz/UniFAR-FTUs huggingface dataset:
A critical evaluation of the concomitant use of the implantable Doppler probe and the Vacuum Assisted Closure system in free tissue transfer

Introduction of the Vacuum‐Assisted Closure (V.A.C.) system has revolutionized the approach to a multitude of clinical settings. Yet, its use precludes adequate clinical monitoring of skin‐grafted free flaps, thus, making a reliable monitoring system essential if broad clinical application is aspired. In a clinical study, the usefulness of the combination of the V.A. C. and implantable Doppler probe was critically evaluated in patients with microsurgical lower extremity reconstruction. We retrospectively analyzed the usefulness of the implantable Doppler probe in five consecutive patients treated in our department from January to July 2007. Inclusion criteria were lower extremity reconstruction by means of skin‐grafted free tissue transfers with subsequent application of the V.A. C. device. Five consecutive patients (four males, one female) with a mean age of 37.8 years (range, 8–58 years) matched the criteria mentioned above. Of note, the two pediatric patients (8‐year‐old male and 12‐year‐old female) suffered from significant posttraumatic stress disorder necessitating concomitant psychological care by the Department of Psychiatry. All flaps healed uneventfully displaying no signs of vascular compromise. Interpretation of the Doppler signal was simple and well received by the nursing staff. The combination of V.A. C. and the implantable Doppler probe enhances patient comfort due to a reduction of the number of dressing changes while still allowing continuous free flap monitoring. Interpretation of the signal transmitted by the probe is simple and potentially reduces misinterpretations due to different levels of experience. © 2008 Wiley‐Liss, Inc. Microsurgery, 2008.
Understanding Attitudes to the European Community: A Social-Psychological Study in Four Member States

List of tables List of illustrations Foreword Acknowledgements 1. The idea of Europe: dream and reality 2. Public opinion and European integration: a review and critique 3. Towards a social-psychological analysis of 'Europeanism' 4. Social representations of the European community: content-analyses of open-ended responses 5. The social psychology of the European community: cross-national comparisons 6. Predicting attitudes towards the European Community: towards a model of underlying structure 7. Conclusion: findings and implications Appendices Notes References Subject index Author index.
Socioeconomic Resources of Parents and Award of Child Support in the United States: Some Exploratory Models.

The American system of family and kinship is undergoing considerable change. Decreasing stability in the nuclear family has called into question the role of parents in providing for children across separate households. A significant proportion of absent parents do not make economic contributions to the well-being of their children. As a consequence, children living in single-parent homes run a greater risk of living in poverty than children in two-parent homes. This study examines the determinants of child support awards and amounts for a sample of ever-divorced women from the National Longitudinal Study of the High School Class of 1972. The argument is that the socioeconomic resources of parents at divorce influence the amount and award of child support. The results indicate that socioeconomic resources are significant predictors of child support outcomes.
Teaching strategies and gender in higher education instrumental studios

This study investigates instrumental music teaching strategies in higher education settings, in order to identify those employed and their frequency and context of use. An instrument- and gender-balanced sample of 24 lessons from five institutions was analysed using a researcher-designed observational instrument. The results reveal the predominance of teacher demonstration, general directives and praise as most frequent teaching strategies employed in lessons. Gender differences emerged in the teaching approaches: the male teachers gave more general directives and explanations and the female teachers offered more answers and practice discussions; the male students received the most specific teacher criticism despite uniform use of praise. The findings provide new evidence of teaching practices in advanced instrumental studios and raise questions regarding gender issues in music teaching.
The impact of moods generated by television programs on responses to advertising

The impact of television-program-generated moods on the processing of embedded advertisements was examined within an experimental setting. Results show that program-induced moods affected the amount of message recall and cognitive responses toward the advertisement. In addition, the results show that the affective bias in the cognitive responses toward the advertisement is affected by program-induced moods. The implications of the results and directions for a program of research are discussed.
A Contingency Approach to Adaptive Selling Behavior and Sales Performance: Selling Situations and Salesperson Characteristics

The Weitz (1981) model of adaptive selling suggests that situational variables will moderate the relationship between adaptive selling behavior and sales performance. In this paper, a path model is analyzed and supports the positive role of adaptive selling on sales performance under “adaptive” conditions. Surprisingly, there is also a positive relationship in the “nonadaptive” condition. Furthermore, salesperson characteristics such as the ability to monitor the selling situation and modify self-behaviors and strategies within the exchange setting are determined to be related to the intention to sell adaptively in the “adaptive” conditions. Finally, results of this study suggest that selling experience affects sales performance in both “adaptive” and “nonadaptive” situational contexts, but the sources of effects differ.
CATEGORY SPECIFICITY AND FEATURE KNOWLEDGE:EVIDENCE FROM NEW SENSORY-QUALITY CATEGORIES

Category-specific deficits and their relation to types of feature knowledge are addressed with respect to three semantic domains: artefacts, living things, and mass-kinds. The performance of a herpes encephalitic patient with a classic category-specific pattern of knowledge, MU, was compared to that of the other HSE patients and normal subjects. In a feature verification task involving over 4000 questions, MU showed a severe impairment with the mass-kind category, where his sensory features knowledge was at chance and much worse than his functional knowledge. In the feature production task, however, MU was grossly impaired with respect to sensory relative to functional features across all categories. Control experiments suggest that the deficits were of knowledge. Overall, these findings give some support to the sensory-functional theory, and are difficult to explain on the domain-specific knowledge theory. However, an account is still needed of the differences observed in MU's performance between the two paradigms.
Phase Ib/II pharmacokinetic/pharmacodynamic (PK/PD) study of combination voreloxin and cytarabine in relapsed or refractory AML patients.

7005 Background: Voreloxin is a naphthyridine analog that intercalates DNA and inhibits topoisomerase II, inducing apoptosis. Clinical activity is observed in ovarian cancer and AML. Voreloxin combined with cytarabine (Ara-C) show supra-additive activity preclinically. Interim results from a phase Ib/II study in relapsed or refractory AML are reported. METHODS Dose-escalation in relapsed/refractory AML patients (pts) with ≤ 3 prior induction regimens; phase II expansion in first-relapse pts (CR1 ≥ 3 months) at MTD. Voreloxin given d1 and d4, combined with: A) continuous infusion 400 mg/m2/d x 5d Ara-C (CIV), or B) bolus 1 g/m2/d IV x 5d Ara-C. Voreloxin starting dose: A) 10 mg/m2/dose; B) 70 mg/m2/dose. TREATMENT induction, reinduction if needed, and up to 2 courses for consolidation. DLT, PK, and PD were assessed in cycle 1. Pts' PBMC were evaluated for induction of DNA damage response markers. Ex vivo sensitivity of pt BMA to voreloxin and Ara-C were evaluated by CellTiter-Glo proliferation assay. RESULTS 52 pts treated to date (A: 41 pts, dose-escalation; 5 pts Phase 2; B: 6 pts dose-escalation). A) MTD is 80 mg/m2/dose voreloxin. Infections are the most common G3 or higher toxicity. Voreloxin PK were dose proportional to 50 mg/m2, then plateaued. Evaluation of PBMC pre- and posttreatment suggests modulation of pDNA-PKcs and pChk2 may reflect response. Ex vivo BMA assay results suggest that voreloxin is the primary contributor to the majority of CRs observed. Phase Ib: 9 CRs + CRp were observed in multiply relapsed or 1° refractory pts. B) 70 mg/m2/dose voreloxin, no DLT; too early to evaluate activity. CONCLUSIONS Voreloxin in combination with CIV Ara-C is generally well-tolerated, with CR in relapsed/refractory pts. Enrollment continues: A) phase II; B) phase Ib. Ex vivo activity assay results suggest that voreloxin is the primary contributor to the majority of CR. Induction of pDNA-PKcs and pChk2 in PBMCs from treated pts may reflect response. [Table: see text].
Autistic Children and Different Tense Forms

Autism spectrum disorder is characterized by abnormalities in social communication, language abilities and repetitive behaviors. The present study focused on some grammatical deficits in autistic children. We evaluated the impairment of correct use of different Persian verb tenses in autistic children’s speech. Two standardized Language Test were administered then gathered data were analyzed. The main result of this study was significant difference between the mean scores of correct responses to present tense in comparison with past tense in Persian language. This study demonstrated that tense is severely impaired in autistic children’s speech. Our findings indicated those autistic children’s production of simple present/ past tense opposition to be better than production of future and past periphrastic forms (past perfect, present perfect, past progressive). Keywords—Autism, Past, Persian Language, Present, Tense
Changes in Mitochondrial Function Resulting from Synaptic Activity in the Rat Hippocampal Slice

Digital imaging microfluorimetry was used to visualize changes in mitochondrial potential and intracellular Ca2+concentration, [Ca2+]i, in thick slices of rat hippocampus. Electrical activity, especially stimulus train-induced bursting (STIB) activity, produced slow, prolonged changes in mitochondrial potential within hippocampal slices as revealed by fluorescence measurements with rhodamine dyes. Changes in mitochondrial potential showed both temporal and spatial correlations with the intensity of the electrical activity. Patterned changes in mitochondrial potential were observed to last from tens of seconds to minutes as the consequence of epileptiform discharges. STIB-associated elevations in [Ca2+]iwere also prolonged and exhibited a spatial pattern similar to that of the mitochondrial depolarization. The mitochondrial depolarization was sensitive to TTX and glutamate receptor blockers ([Mg2+]o and CNQX or DNQX plusd-AP-5) and to the inhibition of glutamate release by activation of presynaptic NPY receptors. The monitoring of mitochondrial potential in slice preparations provides a new tool for mapping synaptic activity in the brain and for determining the roles of mitochondria in regulation of brain synaptic activity.
High-speed indoor visible light communication system employing laser diodes and angle diversity receivers

The two main challenges facing high data rate visible light communication (VLC) are the low modulation bandwidth of the current transmitters (i.e. light emitting diodes, LEDs) and the inter symbol interference (ISI) caused by multipath propagation. In this paper, we evaluate laser diodes (LDs) as a source of illumination and communication instead of LEDs for a VLC system in conjunction with an angle diversity receiver (ADR). The main advantage of using LDs is their high modulation bandwidth that enables communication at data rates of multi gigabits per second for VLC when using a suitable receiver, such as an ADR, which mitigates the ISI. Our proposed system uses simple on-off keying (OOK) modulation, and it is able to provide data rates of 5 Gbps and a bit-error-rate (BER) of 10-6 in the worst case scenario.
The working alliance within time-limited therapy: A case analysis.

A travers deux etudes de cas intensives, cet article traite des alliances professionneles a travers les differentes etapes d'un traitement a orientation psychodynamique a court terme. L'analyse est realisee sur des donnees issues des perceptions de 2 patients, du therapeute, et d'un juge independant. Les implications des resultats sur l'etablissement d'un modele des processus d'evolution (des etapes) d'un traitement a court terme et sur les recherches futures sont egalement discutees
Poselet Conditioned Pictorial Structures

In this paper we consider the challenging problem of articulated human pose estimation in still images. We observe that despite high variability of the body articulations, human motions and activities often simultaneously constrain the positions of multiple body parts. Modelling such higher order part dependencies seemingly comes at a cost of more expensive inference, which resulted in their limited use in state-of-the-art methods. In this paper we propose a model that incorporates higher order part dependencies while remaining efficient. We achieve this by defining a conditional model in which all body parts are connected a-priori, but which becomes a tractable tree-structured pictorial structures model once the image observations are available. In order to derive a set of conditioning variables we rely on the poselet-based features that have been shown to be effective for people detection but have so far found limited application for articulated human pose estimation. We demonstrate the effectiveness of our approach on three publicly available pose estimation benchmarks improving or being on-par with state of the art in each case.
Evolutionary and functional implications of hypervariable loci within the skin virome

Localized genomic variability is crucial for the ongoing conflicts between infectious microbes and their hosts. An understanding of evolutionary and adaptive patterns associated with genomic variability will help guide development of vaccines and anti-microbial agents. While most analyses of the human microbiome have focused on taxonomic classification and gene annotation, we investigated genomic variation of skin-associated viral communities. We evaluated patterns of viral genomic variation across 16 healthy human volunteers. HPV and Staphylococcus phages contained 106 and 465 regions of diversification, or hypervariable loci, respectively. Propionibacterium phage genomes were minimally divergent and contained no hypervariable loci. Genes containing hypervariable loci were involved in functions including host tropism and immune evasion. HPV and Staphylococcus phage hypervariable loci were associated with purifying selection. Amino acid substitution patterns were virus dependent, as were predictions of their phenotypic effects. We identified diversity generating retroelements as one likely mechanism driving hypervariability. We validated these findings in an independently collected skin metagenomic sequence dataset, suggesting that these features of skin virome genomic variability are widespread. Our results highlight the genomic variation landscape of the skin virome and provide a foundation for better understanding community viral evolution and the functional implications of genomic diversification of skin viruses.
Sequential Analysis: Design Methods and Applications Data-efficient Quickest Change Detection with On–off Observation Control Data-efficient Quickest Change Detection with On–off Observation Control

This article may be used for research, teaching, and private study purposes. Any substantial or systematic reproduction, redistribution, reselling, loan, sub-licensing, systematic supply, or distribution in any form to anyone is expressly forbidden. The publisher does not give any warranty express or implied or make any representation that the contents will be complete or accurate or up to date. The accuracy of any instructions, formulae, and drug doses should be independently verified with primary sources. The publisher shall not be liable for any loss, actions, claims, proceedings, demand, or costs or damages whatsoever or howsoever caused arising directly or indirectly in connection with or arising out of the use of this material. Abstract: In this article we extend Shiryaev's quickest change detection formulation by also accounting for the cost of observations used before the change point. The observation cost is captured through the average number of observations used in the detection process before the change occurs. The objective is to select an on–off observation control policy that decides whether or not to take a given observation, along with the stopping time at which the change is declared, to minimize the average detection delay, subject to constraints on both the probability of false alarm and the observation cost. By considering a Lagrangian relaxation of the constraint problem and using dynamic programming arguments, we obtain an a posteriori probability-based two-threshold algorithm that is a generalized version of the classical Shiryaev algorithm. We provide an asymptotic analysis of the two-threshold algorithm and show that the algorithm is asymptotically optimal—that is, the performance of the two-threshold algorithm approaches that of the Shiryaev algorithm— for a fixed observation cost, as the probability of false alarm goes to zero. We also show, using simulations, that the two-threshold algorithm has good observation cost-delay trade-off curves and provides significant reduction in observation cost compared to the naïve approach of fractional sampling, where samples are skipped randomly. Our analysis reveals that, for practical choices of constraints, the two thresholds can be set independent of each other: one based on the constraint of false alarm and another based on the observation cost constraint alone.
Monoterpenoids (thymol, carvacrol and S-(+)-linalool) with anesthetic activity in silver catfish (Rhamdia quelen): evaluation of acetylcholinesterase and GABAergic activity

This study evaluated the anesthetic potential of thymol and carvacrol, and their influence on acetylcholinesterase (AChE) activity in the muscle and brain of silver catfish (Rhamdia quelen). The AChE activity of S-(+)-linalool was also evaluated. We subsequently assessed the effects of thymol and S-(+)-linalool on the GABAergic system. Fish were exposed to thymol and carvacrol (25, 50, 75, and 100 mg/L) to evaluate time for anesthesia and recovery. Both compounds induced sedation at 25 mg/L and anesthesia with 50–100 mg/L. However, fish exposed to carvacrol presented strong muscle contractions and mortality. AChE activity was increased in the brain of fish at 50 mg/L carvacrol and 100 mg/L thymol, and decreased in the muscle at 100 mg/L carvacrol. S-(+)-linalool did not alter AChE activity. Anesthesia with thymol was reversed by exposure to picrotoxin (GABAA antagonist), similar to the positive control propofol, but was not reversed by flumazenil (antagonist of benzodiazepine binding site), as observed for the positive control diazepam. Picrotoxin did not reverse the effect of S-(+)-linalool. Thymol exposure at 50 mg/L is more suitable than carvacrol for anesthesia in silver catfish, because this concentration did not cause any mortality or interference with AChE activity. Thymol interacted with GABAA receptors, but not with the GABAA/benzodiazepine site. In contrast, S-(+)-linalool did not act in GABAA receptors in silver catfish.
Exponential stability of impulsive high-order Hopfield-type neural networks with time-varying delays

This paper considers the problems of global exponential stability and exponential convergence rate for impulsive high-order Hopfield-type neural networks with time-varying delays. By using the method of Lyapunov functions, some sufficient conditions for ensuring global exponential stability of these networks are derived, and the estimated exponential convergence rate is also obtained. As an illustration, an numerical example is worked out using the results obtained.
Adaptive VM Handoff Across Cloudlets

Cloudlet ofﬂoad is a valuable technique for ensuring low end-to-end latency of resource-intensive cloud processing for many emerging mobile applications. This paper examines the impact of user mobility on cloudlet ofﬂoad, and shows that even modest user mobility can result in signiﬁcant network degradation. We propose VM handoff as a technique for seamlessly transferring VM-encapsulated execution to a more optimal ofﬂoad site as users move. Our approach can perform handoff in roughly a minute even over limited WANs by adaptively reducing data transferred. We present experimental results to validate our implementation and to demonstrate effectiveness of adaptation to changing network conditions and processing capacity. This research was supported by the National Science Foundation (NSF) under grant number IIS-1065336. Additional support was provided by the Intel Corporation, Google, Vodafone, and the Conklin Kistler family fund. Any opinions, ﬁndings, conclusions or recommendations expressed in this material are those of the authors and should not be attributed to their employers or funding sources.
Jean Vanier: An Alternative Voice for the Social Work Profession

Social work has tended, in recent years toward an embrace of professionalism and of praxis founded in science and management theory. This article proposes that social work, in its narrowing emphasis on evidence-based practice and on professionalism, moves not only away from its founding traditions, but ignores the informal and unarticulated interventions of its own practitioners. The thought of Jean Vanier related to his deep religious commitment to Christianity, his vision of a caring and loving community, and his use of evocative language to articulate his vision, all contribute to a conception of helping others that challenges the limits of the rational-technical and professional model so endorsed by contemporary social work.