Miracle-dz/UniFAR-FTUs huggingface dataset:
Harnessing Plasmon-Induced Hot Carriers at the Interfaces With Ferroelectrics

This article reviews the scientific understanding and progress of interfacing plasmonic particles with ferroelectrics in order to facilitate the absorption of low-energy photons and their conversion to chemical fuels. The fundamental principles of hot carrier generation and charge injection are described for semiconductors interfaced with metallic nanoparticles and immersed in aqueous solutions, forming a synergistic juncture between the growing fields of plasmonically-driven photochemistry and semiconductor photocatalysis. The underlying mechanistic advantages of a metal-ferroelectric vs. metal-nonferroelectric interface are presented with respect to achieving a more optimal and efficient control over the Schottky barrier height and charge separation. Notable recent examples of using ferroelectric-interfaced plasmonic particles have demonstrated their roles in yielding significantly enhanced photocurrents as well as in the photon-driven production of molecular hydrogen. Notably, plasmonically-driven photocatalysis has been shown to occur for photon wavelengths in the infrared range, which is at lower energies than typically possible for conventional semiconductor photocatalysts. Recent results thus demonstrate that integrated ferroelectric-plasmonic systems represent a potentially transformative concept for use in the field of solar energy conversion.
Activated Microglia in Cortical White Matter Across Cognitive Aging Trajectories

Activation of microglia, the primary mediators of inflammation in the brain, is a major component of gliosis and neuronal loss in a number of age-related neurodegenerative disorders, such as Alzheimer’s disease (AD). The role of activated microglia in white matter, and its relationship with cognitive decline during aging are unknown. The current study evaluated microglia densities in the white matter of postmortem specimens from cognitively normal young adults, cognitively normal older adults, and cognitive “SuperAgers,” a unique group of individuals over age 80 whose memory test scores are at a level equal to or better than scores of 50-to-65-year-olds. Whole hemisphere sections from cognitively normal old, young, and “SuperAgers” were used to quantify densities of human leukocyte antigen-D related (HLA-DR)-positive activated microglia underlying five cortical regions. Statistical findings showed a significant main effect of group on differences in microglia density where cognitively normal old showed highest densities. No difference between SuperAgers and young specimens were detected. In two autopsied SuperAgers with MRI FLAIR scans available, prominent hyperintensities in periventricular regions were observed, and interestingly, examination of corresponding postmortem sections showed only sparse microglia densities. In conclusion, activated microglia appear to respond to age-related pathologic changes in cortical white matter, and this phenomenon is largely spared in SuperAgers. Findings offer insights into the relationship between white matter neuroinflammatory changes and cognitive integrity during aging.
Modeling Analysis of Axonal After Potential at Hippocampal Mossy Fibers

Action potentials reliably propagate along the axons, and after potential often follows the axonal action potentials. After potential lasts for several tens of millisecond and plays a crucial role in regulating excitability during repetitive firings of the axon. Several mechanisms underlying the generation of after potential have been suggested, including activation of ionotropic autoreceptors, accumulation of K+ ions in the surrounding extracellular space, the opening of slow voltage-dependent currents, and capacitive discharge of upstream action potentials passively propagated through axon cable. Among them, capacitive discharge is difficult to examine experimentally, since the quantitative evaluation of a capacitive component requires simultaneous recordings from at least two different sites on the connecting axon. In this study, a series of numerical simulation of the axonal action potential was performed using a proposed model of the hippocampal mossy fiber where morphological as well as electrophysiological data are accumulated. To evaluate the relative contribution of the capacitive discharge in axonal after potential, voltage-dependent Na+ current as well as voltage-dependent K+ current was omitted from a distal part of mossy fiber axons. Slow depolarization with a similar time course with the recorded after potential in the previous study was left after blockade of Na+ and K+ currents, suggesting that a capacitive component contributes substantially in axonal after potential following propagating action potentials. On the other hand, it has been shown that experimentally recorded after potential often showed clear voltage-dependency upon changes in the initial membrane potential, obviously deviating from voltage-independent nature of the capacitive component. The simulation revealed that activation of voltage-dependent K+ current also contributes to shape a characteristic waveform of axonal after potential and reconstitute similar voltage-dependency with that reported for the after potential recorded from mossy fiber terminals. These findings suggest that the capacitive component reflecting passive propagation of upstream action potential substantially contributes to the slow time course of axonal after potential, although voltage-dependent K+ current provided a characteristic voltage dependency of after potential waveform.
Development and Validation of a Nomogram for Predicting Survival in Male Patients With Breast Cancer

Male breast cancer (MBC) is rare, and most patients are diagnosed at an advanced stage. We aimed to develop a reliable nomogram to predict breast cancer-specific survival (BCSS) for MBC patients, thus helping clinical diagnosis and treatment. Based on data from the Surveillance, Epidemiology, and End Results (SEER) database, 2,451 patients diagnosed with MBC from 2010 to 2015 were selected for this study. They were randomly assigned to either a training cohort (n = 1715) or a validation cohort (n = 736). The Multivariate Cox proportional hazards regression analysis was used to determine the independent prognostic factors, which were then utilized to build a nomogram for predicting 3- and 5-year BCSS. The discrimination and calibration of the new model was evaluated using the Concordance index (C-index) and calibration curves, while its accuracy and benefits were assessed by comparing it to the traditional AJCC staging system using the net reclassification improvement (NRI), the integrated discrimination improvement (IDI), and the decision curve analysis (DCA). Multivariate models revealed that age, AJCC stage, ER status, PR status, and surgery all showed a significant association with BCSS. A nomogram based on these variables was constructed to predict survival in MBC patients. Compared to the AJCC stage, the C-index (training group: 0.840 vs. 0.775, validation group: 0.818 vs. 0.768), the areas under the receiver operating characteristic curve of the training set (3-year AUC: 0.852 vs. 0.778, 5-year AUC: 0.841 vs. 0.774) and the validation set (3-year AUC: 0.778 vs. 0.752, 5-year AUC: 0.852 vs. 0.794), and the calibration plots of this model all exhibited better performance. Additionally, the NRI and IDI confirmed that the nomogram was a great prognosis tool. Finally, the 3- and 5-year DCA curves yielded larger net benefits than the traditional AJCC stage. In conclusion, we have successfully established an effective nomogram to predict BCSS in MBC patients, which can assist clinicians in determining the appropriate therapy strategies for individual male patients.
The Relationship Between Austrian Tax Auditors and Self-Employed Taxpayers: Evidence From a Qualitative Study

A constructive, highly professional relationship between tax authorities and taxpayers is essential for tax compliance. The aim of the present paper was to explore systematically the determinants of this relationship and related tax compliance behaviors based on the extended slippery slope framework. We used in-depth qualitative interviews with 33 self-employed taxpayers and 30 tax auditors. Interviewees described the relationship along the extended slippery slope framework concepts of power and trust. However, also novel sub-categories of power (e.g., setting deadlines) and trust (e.g., personal assistance) were mentioned. Furthermore, also little-studied categories of tax behavior emerged, such as accepting tax behavior, e.g., being available to the tax authorities, or stalling tax behavior, e.g., the intentional creation of complexity. The results comprehensively summarize the determinants of the tax relationship and tax compliance behaviors. Additionally, results highlight future research topics and provide insights for policy strategies.
A Perspective on Objective Measurement of the Perceived Challenge of Walking

Perceived challenge of walking is a broad term that we use to encompass walking-related anxiety, balance self-efficacy/confidence, and fear of falling. Evidence shows that even after accounting for physical performance capabilities, a higher perceived challenge can cause individuals to self-impose restrictions in walking-related activities. Perceived challenge is typically measured by self-report, which is susceptible to subjective measurement bias and error. We assert that measurement of perceived challenge can be enhanced by augmenting self-report with objective, physiologically based measures. A promising approach that has emerged in the literature is measurement of sympathetic nervous system (SNS) activity by recording skin conductance. Heightened SNS activity is a physiological stress response to conditions that are cognitively, emotionally, or physically challenging. In the present article, we explain the rationale and physiological basis for measuring SNS activity to assess perceived challenge of walking. We also present existing and new evidence supporting the feasibility of this approach for assessing perceived challenge in lab-based and real-world walking environments. Future research directions are also discussed.
Shyness Weakens the Agreeableness-Prosociality Association via Social Self-Efficacy: A Moderated-Mediation Study of Chinese Undergraduates

Using a sample of 1383 undergraduate students (Mage = 20.06, Nfemale = 817), this study tested a moderated mediation model in which shyness moderated the association between agreeableness and prosocial behavior, as well as the relation between agreeableness and social self-efficacy (SSE). Results showed (when gender, age, and family socio-economic status were controlled) that agreeableness exerted a positive effect on prosocial behavior (PSB) toward three types of recipients (i.e., family members, friends/acquaintances, strangers), and this effect was mediated by SSE and moderated by shyness. The relationships between agreeableness and PSB were more positive under low shyness than that under high shyness condition. In addition, shyness also moderated the first stage of mediation model (i.e., the agreeableness-SSE association), showing that the relation between agreeableness and SSE was more positive under low shyness than that under high shyness condition. Identifying the moderation effect of shyness provides evidence that personality traits may operate in an interactive manner. This may shed new light on why there are inconsistent findings regarding the agreeableness-prosociality association.
Temporal Markov Processes for Transport in Porous Media: Random Lattice Networks

Monte Carlo (MC) simulations of transport in random porous networks indicate that for high variances of the lognormal permeability distribution, the transport of a passive tracer is non‐Fickian. Here we model this non‐Fickian dispersion in random porous networks using discrete temporal Markov models. We show that such temporal models capture the spreading behavior accurately. This is true despite the fact that the slow velocities are strongly correlated in time, and some studies have suggested that the persistence of low velocities would render the temporal Markovian model inapplicable. Compared to previously proposed temporal stochastic differential equations with case‐specific drift and diffusion terms, the models presented here require fewer modeling assumptions. Moreover, we show that discrete temporal Markov models can be used to represent dispersion in unstructured networks, which are widely used to model porous media. A new method is proposed to extend the state space of temporal Markov models to improve the model predictions in the presence of extremely low velocities in particle trajectories and extend the applicability of the model to higher temporal resolutions. Finally, it is shown that by combining multiple transitions, temporal models are more efficient for computing particle evolution compared to correlated CTRW with spatial increments that are equal to the lengths of the links in the network.
Differential Cellular Expression of Galectin-1 and Galectin-3 After Intracerebral Hemorrhage

Intracerebral hemorrhage (ICH) is a devastating sub-type of stroke with no proven treatment. Given the emerging role of Galectin-1 and Galectin-3 in neuroimmune responses, the objective of the current manuscript is to elucidate hemorrhagic-injury induced modulation and cellular expression of Galectin-1 and Galectin-3 in the brain in a pre-clinical model of ICH. To address this, ICH was induced in male CD1 mice by collagenase injection method. Western blotting as well as Immunofluorescence staining was performed to characterize the temporal expression pattern as well as cellular localization of Galectin-1 and Galectin-3 after ICH. Further, genetic studies were conducted to assess the functional role of Galectin-1 and Galectin-3 in inflammatory response employing a murine macrophage cell line, RAW 264.7. Galectin-1 and Galectin-3 exhibited very profound and increased expression from day 3 to day 7-post-injury, in the perihematomal brain region after ICH in comparison to Sham. Further, Galectin-1 expression was mostly observed in GFAP-positive astrocytes whereas Galectin-3 expression was observed mostly in Iba1-positive microglia/macrophages as well as CD16/32 (M1 microglial/macrophage marker)-positive cells. Moreover, genetic studies revealed a negative regulatory role of both Galectin-1 and Galectin-3 in the release of a proinflammatory cytokine, IL-6 from RAW 264.7 cells depending on the stimulus. Altogether, the present manuscript demonstrates for the first time, increased expression as well as cellular localization of Galectin-1 and Galectin-3 in the perihematomal brain regions after ICH. In addition, the manuscript raises the potential of Galectin-1 and Galectin-3 in modulating glial responses and thereby brain injury after ICH, warranting further investigation.
Are Insomnia Type Sleep Problems Associated With a Less Physically Active Lifestyle? A Cross-Sectional Study Among 7,700 Adults From the General Working Population

Background: Sleep problems are common in the general population and negatively affect both private and work life. A vicious circle may exist between poor sleep and an unhealthy lifestyle. For example, poor sleep may drain the energy to do health-promoting physical activity during leisure-time after work. The aim of the present study was to investigate the association between sleep problems and the duration of low- and high-intensity leisure-time physical activity in sedentary and physical workers. Methods: This cross-sectional study employ data from the Danish Work Environment Cohort Study in 2010, where currently employed wage-earners in Denmark on daytime schedule (N = 7,706) replied to questions about sleep quality (cf. the Bergen Insomnia Scale) and participation in low- and high-intensity leisure-time physical activity. Associations were modeled using general linear models controlling for various confounders. Results: Workers with high levels of sleep problems reported less high-intensity leisure-time physical activity. Specifically, the weekly duration of high-intensity leisure-time physical activity was 139 (95%CI 111–168), 129 (95%CI 101–158), and 122 (95%CI 92–151) min in sedentary workers with sleep problems < 1, 1–3, and ≥3 days per week, respectively. The same pattern was observed among physical workers. In sedentary workers ≥50 years, the fully adjusted model showed a weekly duration in high-intensity physical activity during leisure of 122 (95%CI 83–161), 102 (95%CI 64–141), and 90 (95%CI 51–130) among those with sleep problems < 1, 1–3, and ≥3 days per week, respectively. Conclusions: Workers, particularly sedentary older workers, having sleep problems report less high-intensity leisure-time physical activity. These data suggest that a vicious circle may indeed exist between poor sleep and reduced leisure-time physical activity.
The mechanism of topoisomerase I poisoning by a camptothecin analog

We report the x-ray crystal structure of human topoisomerase I covalently joined to double-stranded DNA and bound to the clinically approved anticancer agent Topotecan. Topotecan mimics a DNA base pair and binds at the site of DNA cleavage by intercalating between the upstream (−1) and downstream (+1) base pairs. Intercalation displaces the downstream DNA, thus preventing religation of the cleaved strand. By specifically binding to the enzyme–substrate complex, Topotecan acts as an uncompetitive inhibitor. The structure can explain several of the known structure–activity relationships of the camptothecin family of anticancer drugs and suggests that there are at least two classes of mutations that can produce a drug-resistant enzyme. The first class includes changes to residues that contribute to direct interactions with the drug, whereas a second class would alter interactions with the DNA and thereby destabilize the drug-binding site.
Contaminant and Environmental Influences on Thyroid Hormone Action in Amphibian Metamorphosis

Aquatic and terrestrial environments are increasingly contaminated by anthropogenic sources that include pharmaceuticals, personal care products, and industrial and agricultural chemicals (i. e., pesticides). Many of these substances have the potential to disrupt endocrine function, yet their effect on thyroid hormone (TH) action has garnered relatively little attention. Anuran postembryonic metamorphosis is strictly dependent on TH and perturbation of this process can serve as a sensitive barometer for the detection and mechanistic elucidation of TH disrupting activities of chemical contaminants and their complex mixtures. The ecological threats posed by these contaminants are further exacerbated by changing environmental conditions such as temperature, photoperiod, pond drying, food restriction, and ultraviolet radiation. We review the current knowledge of several chemical and environmental factors that disrupt TH-dependent metamorphosis in amphibian tadpoles as assessed by morphological, thyroid histology, behavioral, and molecular endpoints. Although the molecular mechanisms for TH disruption have yet to be determined for many chemical and environmental factors, several affect TH synthesis, transport or metabolism with subsequent downstream effects. As molecular dysfunction typically precedes phenotypic or histological pathologies, sensitive assays that detect changes in transcript, protein, or metabolite abundance are indispensable for the timely detection of TH disruption. The emergence and application of ‘omics techniques—genomics, transcriptomics, proteomics, metabolomics, and epigenomics—on metamorphosing tadpoles are powerful emerging assets for the rapid, proxy assessment of toxicant or environmental damage for all vertebrates including humans. Moreover, these highly informative ‘omics techniques will complement morphological, behavioral, and histological assessments, thereby providing a comprehensive understanding of how TH-dependent signal disruption is propagated by environmental contaminants and factors.
Limitation in the Photosynthetic Acclimation to High Temperature in Canopy Leaves of Quercus serrata

As temperature dependence in many biological precesses is generally a bell-shaped curve, warming may be benefitial at cooler climate but deterimental at warmer climate. Although warming responses are expected to vary between different temperature regimes even in the same species, such variations are poorly understood. We established open-top canopy chambers, in which average daytime leaf temperature was increased by ca. 1.0°C, at the canopy top of Quercus serrata in a deciduous forest in high (HL) and low (LL) latitude sites and studied temperature dependence of photosynthesis in the leaves across seasons. In control leaves, photosynthetic rates were higher in LL than in HL. Reponse to warming was different between HL and LL; an increase in growth temperature increased photosynthetic rates at higher leaf temperatures in HL but decreased in LL. Lower photosynthetic rate in the warming treatment in LL was partly explained by lower leaf mass per area and leaf nitrogen content per unit leaf area. Optimal temperature that maximizes photosynthetic rate (Topt) linearly increased with increasing growth temperature (GT) in HL, whereas it was saturating against GT in LL, suggesting that Topt in Q. serrata has an upper limit. The variation in Topt was explained by the activation energy of the maximum carboxylation rate (EaV). Our results suggest an upper limit in temperature acclimation of photosynthesis, which may be one of the determinants of southern limitation of the distribution.
Beyond Social Exchange: Career Adaptability Linking Work Stressors and Counterproductive Work Behavior

Drawing upon career construction theory (Savickas, 2002, 2013) and the job demand-control-support model (JDCS; Johnson and Hall, 1988; Van der Doef and Maes, 1999), the present study aims to explore the adaptability resources mechanism of the relationship between work stressors and counterproductive work behavior (CWB). Two-wave data were collected from 305 employees working in the operation department of an e-commerce company. The results showed that career adaptability mediated the relationship between work stressors and CWB against both coworkers (CWB-I) and the organization (CWB-O), going above, and beyond the mediation effect of job satisfaction (i.e., an indicator of a social exchange path). Also, the association between career adaptability and CWB-O was stronger among employees who perceived a low (vs. high) level of organizational support. This study sheds light on how work stressors are related to CWBs indirectly through career adaptability. The findings also offer practical advice for organizations to prevent CWBs by developing employees’ adaptability.