Miracle-dz/UniFAR-FTUs huggingface dataset:
BRD7, a novel bromodomain gene, inhibits G1–S progression by transcriptionally regulating some important molecules involved in ras/MEK/ERK and Rb/E2F pathways

Bromodomain is a 110 amino acid domain. It is evolutionally conserved and is found in proteins strongly implicated in signal‐dependent transcriptional regulation. BRD7 is a novel bromodomain gene and it is downexpressed in nasopharyngeal carcinoma (NPC) biopsies and cell lines; its function is poorly understood. In the present study, tet‐on inducible expression system was used to investigate the role of BRD7 in cell growth and cell cycle progression. We found that ectopic expression of BRD7 in NPC cells inhibited cell growth and cell cycle progression from G1 to S. We further performed cell cycle cDNA array to screen potential transcriptional targets of BRD7 in cell cycle. Thirteen important signaling molecules, mainly implicated in ras/MEK/ERK and Rb/E2F pathways, were differentially expressed by induction of BRD7. Moreover, we observed that BRD7 could regulate the promoter activity of E2F3, one of its targets. Taken together, the present study indicated that BRD7 inhibited G1–S progression by transcriptionally regulating some important molecules involved in ras/MEK/ERK and Rb/E2F pathways and suggested that BRD7 may present a promising candidate of NPC™ associated tumor suppressor gene. © 2004 Wiley‐Liss, Inc.
Fine-tuning language policy in Hong Kong education: stakeholders’ perceptions, practices and challenges

The present study evaluates the impact of the fine-tuning medium of instruction (MOI) policy in Hong Kong in the early stages of its implementation. It explores the key stakeholders’ perspectives on a school-based policy via a case study, which gathered multiple sources of qualitative data (i.e. focus groups/interviews, open-ended questionnaires, school documents and lesson observations). The findings reveal that the increased amount of English-medium teaching encouraged by the new policy has led to the emergence of numerous controversial pedagogical and practical issues, many of which resemble those also occurring in bilingual education programmes worldwide. The evidence suggests that the school-based MOI policy and practices have only benefited the more capable students but sacrificed the interests and learning needs of less able students. The paper, therefore, highlights the need to inform local teachers and administrators on how to confront these difficulties based on their own experience so as to maximise the effectiveness and learning outcomes of the majority of the students.
The Making of Female Presidents and Prime Ministers: The Impact of Birth Order, Sex, of Siblings, and Father-Daughter Dynamics

Although research into the factors that may affect male achievement of political leadership is relatively robust, very few studies on the making of female presidents and prime ministers exist. This paper examines the literature on birth order, sex of siblings, and parent-daughter dynamics to see whether the findings for male political leaders—that first-born individuals will be overrepresented as compared with later-born siblings—also hold for female ones. Two other hypotheses were tested concerning differences in birth order and sex of siblings between female political leaders and a larger sample of women. A review of the literature on parent-daughter dynamics suggests that this may be another important variable for future research into explanations for the success of women who achieve senior-level positions of power. The findings suggest that first-born women, like first-born men, are overrepresented among political leaders; that first-born women are overrepresented among female political leaders as compared with their numbers in a larger sample population; and that fewer female political leaders have an older brother than would be expected to occur in a larger sample population. The last finding applies only for women who come to power in the period 1960–1989, not those who gained office more recently.
Temporal Discrimination and Parents with Learning Difficulties in the Child Protection System

This article shows how time works against parents with learning difficulties in the child protection system and Children Act proceedings. The prevailing wisdom, embedded in policy and the literature, is that delay in care cases is bad for the child and may jeop ardize his or her future. This paper shows how the pressure to avoid delay might itself be harming some families, especially parents with learning difficulties. Drawing on interviews with social work practitioners undertaken as part of a larger study, the authors describe the various forms of temporal discrimination that impact on this group of disabled parents. They conclude that procedural time limits make it harder for parents with learning difficulties to meet the standards and expectations enforced by Children's Services and the courts.
Do they [all] see my true self? Leader's relational authenticity and followers' assessments of transformational leadership

Responding to calls for a more positive and holistic perspective on leadership, Gardner, Avolio, Luthans, May, and Walumbwa (2005), Ilies, Morgeson, and Nahrgang (2005), and Luthans and Avolio (2003) have discussed the concept of authentic leadership. However, up to this point, little is known on how leader authenticity influences leader relationships with followers. Consistent with the overall theme of this special issue, we seek to fill this gap by investigating empirically how leader authenticity predicts transformational leadership behaviours. Specifically, we focus on relational authenticity as a component of authenticity because it has been argued to be particularly salient for interpersonal relationships (Ilies et al., 2005). We further propose that leader authenticity is associated with a greater convergence of followers' perceptions of transformational leadership behaviours. Finally, we predict that not all group members will be influenced by leader authenticity to the same extent. Instead, we hypothesize and find that more critical group members are especially likely to be positively influenced by leader authenticity.
Sensitivity and Specificity of 3-phase Bone Scintigraphy in the Diagnosis of Complex Regional Pain Syndrome of the Upper Extremity

ObjectivesJoint and bone alterations are seldom mentioned in the diagnostic criteria for complex regional pain syndrome (CRPS) even though they are important for long-term outcome. Altered periarticular bone metabolism can be detected by 3-phase bone scintigraphy (TPBS). Although frequently examining the diagnostic efficacy of TPBS is debatable. MethodsIn all, 78 TPBS (45 CRPS/33 control group) were evaluated qualitatively and quantitatively. Sensitivity and specificity of the qualitative blinded reviewer analysis (n=57) compared with quantitative region of interest (ROI)-based analysis over the metacarpophalangeal, proximal, and distal interphalangeal joints (n=74) were evaluated. Patients' sex, age, duration of CRPS, inciting event, extent of joint alteration, and handedness were included as covariables. ResultsQualitative blinded reviewer TPBS analysis had a high specificity (83%-100%). However, sensitivity was 31% to 50%. Interrater reliability was moderate (κ score 0.56). Using the ROI-based evaluation, the highest sensitivity (69%) and specificity (75%) (ROI score ≥1.32) was shown for phase 3, whereas sensitivity of phases 1 and 2 rapidly declined to 50%. Duration of CRPS until TPBS was the only variable with significant impact on ROI scores of phase 3 (F=23.7; P=0.000; R2=0.42). ROI scores declined with increasing duration of CRPS. DiscussionIn conclusion, TPBS is a highly specific tool for diagnosing CRPS of the upper limb. ROI evaluation of phase 3 within the first 5 months after onset of CRPS is an appropriate additional diagnostic tool to confirm or exclude CRPS of the upper extremity.
A new approach to dynamic self-tuning of database buffers

Current businesses rely heavily on efficient access to their databases. Manual tuning of these database systems by performance experts is increasingly infeasible: For small companies, hiring an expert may be too expensive; for large enterprises, even an expert may not fully understand the interaction between a large system and its multiple changing workloads. This trend has led major vendors to offer tools that automatically and dynamically tune a database system. Many database tuning knobs concern the buffer pool for caching data and disk pages. Specifically, these knobs control the buffer allocation and thus the cache miss probability, which has direct impact on performance. Previous methods for automatic buffer tuning are based on simulation, black-box control, gradient descent, and empirical equations. This article presents a new approach, using calculations with an analytically-derived equation that relates miss probability to buffer allocation; this equation fits four buffer replacement policies, as well as twelve datasets from mainframes running commercial databases in large corporations. The equation identifies a buffer-size limit that is useful for buffer tuning and powering down idle buffers. It can also replace simulation in predicting I/O costs. Experiments with PostgreSQL illustrate how the equation can help optimize online buffer partitioning, ensure fairness in buffer reclamation, and dynamically retune the allocation when workloads change. It is also used, in conjunction with DB2's interface for retrieving miss data, for tuning DB2 buffer allocation to achieve targets for differentiated service.
A Brief Report

The goal of the study was to assess positive factors that contribute to African American students’intentions to stay in school. Two hundred and thirty-one African American students participated in this study. Using the theory of planned behavior (TPB) as a conceptual model, surveys measured student attitudes toward school-year completion, social support for completing the academic year, and their perceptions of personal control over school completion. The contributions of self-esteemand racial self-esteemwere also examined for their influence on academic strivings. The TPB was a better predictor of intentions to complete the school year than student grade point averages (GPAs). Self-esteemadded only slightly to the variance explained in predicting intentions to complete the school year, but neither self-esteemnor racial self-esteemwas a significant predictor of GPAs.
The shifting lenses of academic development: on identities, careers, and programmes

In The Ground Beneath Her Feet, one of Salman Rushdie’s characters remarks that ‘[t]he only people who see the whole picture . are the ones who step out of the frame’ (Rushdie, 1999, p. 43). It’s no coincidence that the narrator of that novel is a photographer – one who views the world through a lens, capturing it for posterity, sharing it with his audience. In some ways, the photographer’s world mirrors that of the researcher: our studies present metaphorical snapshots, providing readers with new perspectives as we seek to step back – out of the frame, as best we can – to see the larger picture, to consider the impact and implications of our findings. One of the pleasures of working with IJAD is having the opportunity to see the varied images captured by academic developers around the world and how they focus their lenses on different scales, from the big picture to the fine detail; in the behind-the-scenes review process, we also see how the feedback of expert colleagues helps authors bring into focus key insights from their projects. In this issue, we present articles from authors whose focus is trained on the nature of being an academic, on the careers of academic developers, and on the programmes and methods that academic developers commonly use. Our first pairing of articles examines academic identities. Neil McLean transfers a research method from psychology to a higher education setting. He proposes ‘discursive psychology’ as a means of interrogating new professors’ academic identity development, providing examples from a single tutor’s writing over a two-year period as part of a teaching portfolio. In so doing, McLean demonstrates how this approach can be used to track academics’ identity development and encourages us to consider adding it to our repertoire of qualitative methods in higher education research. The contribution from Damian Ruth and Kogi Naidoo – a developerturned-lecturer and an academic developer, respectively – contrasts with McLean’s: it is a study of their reflective journaling process over a medium timeframe, in which the authors analyse tensions in framing their enquiry, in separating (or not) the personal from the professional, and in professional academic practice itself. Their candid account and reflections offer academic developers insight into the potential of extended, structured one-on-one consultancy. Combined, these two articles ask us to consider the extent to which academic developers can nurture the identity formation of educators on our campuses and broaden our portfolio of approaches for this complex, messy, transformative work. For some of us, our own identity formation experiences a shift – in some cases a jolt – in transitioning roles from ‘regular’ academic to academic developer, dragInternational Journal for Academic Development Vol. 17, No. 2, June 2012, 93–95
LYMPHOID NEOPLASIA MOZ regulates B-cell progenitors and , consequently , Moz haploinsuf fi ciency dramatically retards MYC-induced lymphoma development

During hematopoiesis, relatively quiescent stem cells differentiate in a step-wise manner through progenitor stages to form mature blood cells. Chromatin modifications, and the nuclear enzymes that produce them, are intimately linked to gene transcription and play a central role in regulating hematopoiesis. Not surprisingly, given the importance of chromatin in regulating hematopoietic stem and progenitor cells, mutations in genes encoding epigenetic regulators are commonly found in leukemia and lymphoma. The monocytic leukemia zinc finger protein, MOZ (MYST3; KAT6A), regulates chromatin conformation by acetylating histones. MOZ was first identified in a recurrent t(8;16)(p11;p13) chromosomal translocation leading to the fusion ofMOZ with CBP in cases of acute myeloid leukemia (AML). Since its discovery, additional translocation partners ofMOZ including p300, TIF2, and NCOA3 have been described. TheMOZ-TIF2 chromosomal translocation has been studied in detail. The MOZ-TIF2 fusion protein confers selfrenewing properties upon hematopoietic progenitors leading to transplantable leukemia. AMLarising fromMOZ-chromosomal translocations is particularly aggressive. The median survival of patients with MOZ–translocation-driven leukemia is reported to be between 2 and 10 months post-diagnosis. This shows that the deregulation of MOZ has potent effects on the progression of hematopoietic malignancies. Consistent with its role in leukemia, the endogenous Moz gene is essential for the establishment of hematopoietic stem cells (HSCs) during murine development. This role of MOZ is dependent on its histone acetyltransferase activity, as mice homozygous for a point mutation that affects its catalytic domain show decreased HSC activity. Furthermore, the same mice have decreased numbers of immature B cells, suggesting that MOZ may regulate B-cell development at the chromatin level. Because the regulation of progenitor proliferation is critical for producing normal numbers of blood cells, and also because MOZ is a chromatin regulator intimately involved in hematopoiesis and leukemia, we have examined the role of MOZ in B-cell progenitors in healthy mice and in a mouse model of MYC-driven lymphoma. We examined Em-Myc transgenic mice, which model the genetic lesion found inhumanBurkitt lymphoma, t(8;14)(q24;q32). This translocation brings the Myc gene under the control of an immunoglobulin heavy chain regulatory element. The lymphoid-specific immunoglobulin
An Interactive Input–Process–Output Model of Social Influence in Decision-Making Groups

The first goal of this article is to demonstrate that the dichotomy between informational and normative influence in group decision making is long outdated and should be replaced with a distinction among compliance, comparison, and argumentation influence processes. The second goal of this article is to use this distinction as the basis for a literature review of the impact of various input factors on social influence during small group discussion. The third goal of this article is to present the Simplified Model of Group Social Influence Processes, an interactive input–process–output model relevant to decision-making groups. The article ends with a discussion of the implications of this model for future research and further model development.
Response to Pneumococcal Polysaccharide Vaccination in HIV-Positive Individuals on Long Term Highly Active Antiretroviral Therapy

Background and objectives Streptococcus pneumoniae continues to cause serious infections in HIV-positive individuals in the era of highly active anti-retroviral therapy. This led to the recommendation to revaccinate HIV-positive individuals with PPV23 five years after primary vaccination. The benefits of revaccination and the impact of long term highly active anti-retroviral therapy (HAART) on antigen-specific B cell reconstitution have remained unclear thus far and were investigated. Design and methods We assessed antibody levels, opsonophagocytic activity and phenotype of pneumococcal polysaccharide (PPS) specific-B cells post-revaccination in long term HAART cohorts stratified according to CD4 count as group A (CD4>200) and group B (CD4<200). Anti-PPS IgG, IgM and functional antibody response against vaccine serotypes 14 and 23F were measured by ELISA and opsonophagocytic assay followed by phenotypic analysis of PPS14 and 23F-specific B cells using fluorescently labeled PPS. Results Significant increases in total and functional antibody titers were noted in groups A and B post-vaccination concomitant with significant rise in PPS-specific IgM memory B cells, a critical B cell subset required for protection against PPS although the overall response remained significantly diminished compared to HIV-negative volunteers. Conclusion Comparable increases in opsonophagocytic titers between study groups A and B concomitant with a comparable rise in PPS-specific IgM memory B cells indicate revaccination to be beneficial regardless of the degree of CD4 T cell reconstitution. These findings emphasize the importance of defining effective vaccination practices amongst high-risk individuals.
[Relationship between genetic polymorphisms of N-acetyltransferase and susceptibility to hepatocellular carcinoma].

OBJECTIVE To study the possible relationship between genetic polymorphism of N-acetyltransferase 2 (NAT2) and susceptibility to hepatocellular carcinoma. METHODS Genetic polymorphisms of the four NAT2 genes in 78 patients with hepatocellular carcinoma and 112 healthy controls were analyzed by means of real-time fluorescence light-Cycler. The difference in frequencies between the hepatocellular carcinoma patients and the controls were compared. RESULTS The significant difference in slow acetylation genotype frequency was found between the controls and the hepatocellular carcinoma patients who were smokers (17.9% vs 37.5%, x(2)= 4.67, P<0.05) resulting in increased by 2.76 times the risk for hepatocellular carcinoma, but no evident difference between the controls and hepatocellular carcinoma patients who were non-smokers. CONCLUSION The smokers with slow acetylation genotype of N-acetyltransferase 2 may be the population with high risk for hepatocellular carcinoma.
Study of Charge Carrier Transport in GaN Sensors

Capacitor and Schottky diode sensors were fabricated on GaN material grown by hydride vapor phase epitaxy and metal-organic chemical vapor deposition techniques using plasma etching and metal deposition. The operational characteristics of these devices have been investigated by profiling current transients and by comparing the experimental regimes of the perpendicular and parallel injection of excess carrier domains. Profiling of the carrier injection location allows for the separation of the bipolar and the monopolar charge drift components. Carrier mobility values attributed to the hydride vapor phase epitaxy (HVPE) GaN material have been estimated as μe = 1000 ± 200 cm2/Vs for electrons, and μh = 400 ± 80 cm2/Vs for holes, respectively. Current transients under injection of the localized and bulk packets of excess carriers have been examined in order to determine the surface charge formation and polarization effects.
What and Where Information in the Caudate Tail Guides Saccades to Visual Objects

We understand the world by making saccadic eye movements to various objects. However, it is unclear how a saccade can be aimed at a particular object, because two kinds of visual information, what the object is and where it is, are processed separately in the dorsal and ventral visual cortical pathways. Here, we provide evidence suggesting that a basal ganglia circuit through the tail of the monkey caudate nucleus (CDt) guides such object-directed saccades. First, many CDt neurons responded to visual objects depending on where and what the objects were. Second, electrical stimulation in the CDt induced saccades whose directions matched the preferred directions of neurons at the stimulation site. Third, many CDt neurons increased their activity before saccades directed to the preferred objects and directions of the neurons in a free-viewing condition. Our results suggest that CDt neurons receive both “what” and “where” information and guide saccades to visual objects.
Leisure, nature and environmental movements in the mass media: comparing Jumbo Pass and the Tobeatic Wilderness Area, Canada

Media coverage from major provincial and national newspapers is used to examine two Canadian sites where leisure and tourism become objects of environmental movement mobilisation: the proposed Jumbo Glacier Resort ski development (British Columbia), and the Tobeatic Wilderness Area (Nova Scotia). In both cases, environmentalists and government appear as central news sources. A dominant discourse defines both of these places as wilderness landscapes that need protection from ecologically inappropriate modes of outdoor recreation (downhill skiing and off-highway vehicle use). There are also key differences between the two cases. First, while motorised recreation is defined as inherently incompatible with the wilderness values of the Tobeatic, environmentalists ally with heli-ski operators at Jumbo Pass in their opposition to resort development. Second, news coverage of Jumbo Pass offers more space to environmentalist opponents to question the ‘wilderness’ status of the region. Finally, in the Jumbo case, tourism is linked to economic development in opposition to ecological protection. By contrast, tourism in the Tobeatic is interpreted as a pro-environmental alternative to extractive development. Despite differences between these conflicts, both demonstrate that the relationship between outdoor recreation and environmentalism may be conflictual, rather than mutually supportive.