Miracle-dz/UniFAR-FTUs huggingface dataset:
PROSPECTS FOR THE FUTURE OF THE U.S. HEALTHCARE INDUSTRY: A SPECULATIVE ANALYSIS

This paper examines the future of U.S. healthcare industry. The paper identifies a collection of unprecedented forces that will dramatically reshape industry boundaries, structures, and practices over the next two decades. Key findings include: 1) Regulatory and legislative policy uncertainty raises questions about the long-term relevance of the Affordable Care Act (ACA), 2) industry transformation will be marked by significant and protracted structural changes as innovations in digital technologies, health sciences, health consumer engagement and medical practices play out, 3) regulatory directives and care delivery objectives will drive increased industry transparency, information sharing, and collaboration, 4) advances in genomics will reconceptualize disease typologies, diagnostic tools, and therapies, and, 5) a heightened emphasis on the quality of the health consumer experience will push policy makers and care providers to reform business models and industry economics. The paper concludes with implications and recommendations.
Hydroxychloroquine modulates elevated expression of S100 proteins in systemic lupus erythematosus

Objectives We investigated the effect of hydroxychloroquine (HCQ) on S100A8 and S100A9 serum levels in systemic lupus erythematosus (SLE) patients with low disease activity receiving immunosuppressants. Methods SELENA-SLEDAI, Cutaneous Lupus Erythematous Disease Area and Severity Index (CLASI) and serum levels of complement factors, anti-dsDNA antibodies, and white blood cell, lymphocyte, and platelet counts were used to evaluate disease activity, cutaneous disease activity, and immunological activity, respectively. Serum S100A8 and S100A9 were measured at HCQ administration and after 3 or 6 months using ELISA. Results S100A8 and S100A9 serum levels were elevated at baseline and the magnitude of decrease from baseline at 3 and 6 months after HCQ administration was greater in patients with renal involvement than in those without (baseline: S100A8, p = 0.034; S100A9, p = 0.0084; decrease: S100A8, p = 0.049; S100A9, p = 0.023). S100 modulation was observed in patients with (n = 17; S100A8, p = 0.0011; S100A9, p = 0.0002) and without renal involvement (n = 20; S100A8, p = 0.0056; S100A9, p = 0.0012), and was more apparent in patients with improved CLASI activity scores (improved: S100A8, p = 0.013; S100A9, p = 0.0032; unimproved: S100A8, p = 0.055; S100A9, p = 0.055). No associations were observed for immunological biomarkers. Conclusion HCQ may improve organ involvement in SLE by modulating S100 protein levels, especially in patients with renal or skin involvement.
The relationships between self-efficacy, self-control, chronotype, procrastination and sleep problems in young adults

ABSTRACT The main aim of our study was to examine whether there was a relationship between psychological characteristics such as self-efficacy, self-control and chronotype as well as procrastination on the one hand and sleep problems on the other. There were 315 young adults aged between 18 and 27 years (M = 20.57). We used the General Procrastination Scale, the General Self-Efficacy Scale (GSES), Brief Self-Control Scale, the Composite Scale of Morningness (CSM) and the Pittsburgh Sleep Quality Index (PSQI). Our results indicated that low self-efficacy, low self-control and eveningness were positive predictors of procrastination. The reciprocal relationship exists between procrastination and sleep problems. Procrastination positively contributed to sleep problems, whereas sleep problems were a negative predictor of procrastination.
Isolated Lung Perfusion as an Adjuvant Treatment of Colorectal Cancer Lung Metastases: A Preclinical Study in a Pig Model

Background The lung is a frequent site of colorectal cancer (CRC) metastases. After surgical resection, lung metastases recurrences have been related to the presence of micrometastases, potentially accessible to a high dose chemotherapy administered via adjuvant isolated lung perfusion (ILP). We sought to determine in vitro the most efficient drug when administered to CRC cell lines during a short exposure and in vivo its immediate and delayed tolerance when administered via ILP. Methods First, efficacy of various cytotoxic molecules against a panel of human CRC cell lines was tested in vitro using cytotoxic assay after a 30-minute exposure. Then, early (operative) and delayed (1 month) tolerance of two concentrations of the molecule administered via ILP was tested on 19 adult pigs using hemodynamic, biological and histological criteria. Results In vitro, gemcitabine (GEM) was the most efficient drug against selected CRC cell lines. In vivo, GEM was administered via ILP at regular (20 µg/ml) or high (100 µg/ml) concentrations. GEM administration was associated with transient and dose-dependant pulmonary vasoconstriction, leading to a voluntary decrease in pump inflow in order to maintain a stable pulmonary artery pressure. After this modulation, ILP using GEM was not associated with any systemic leak, systemic damage, and acute or delayed histological pulmonary toxicity. Pharmacokinetics studies revealed dose-dependant uptake associated with heterogenous distribution of the molecule into the lung parenchyma, and persistent cytotoxicity of venous effluent. Conclusions GEM is effective against CRC cells even after a short exposure. ILP with GEM is a safe and reproducible technique.
Faraday Rotation Measure Gradients from a Helical Magnetic Field in 3C 273

Using high-frequency (12-22 GHz) VLBA observations, we confirm the existence of a Faraday rotation measure gradient of ~500 rad m-2 mas-1 transverse to the jet axis in the quasar 3C 273. The gradient is seen in two epochs spaced roughly 6 months apart. This stable transverse rotation-measure gradient is expected if a helical magnetic field wraps around the jet. The overall order to the magnetic field in the inner projected 40 pc is consistent with a helical field. However, we find an unexpected increase in fractional polarization along the edges of the source, contrary to expectations. This high fractional polarization rules out internal Faraday rotation but is not readily explained by a helical field. After correcting for the rotation measure, the intrinsic magnetic field direction in the jet of 3C 273 changes from parallel to nearly perpendicular to the projected jet motion at two locations. If a helical magnetic field causes the observed rotation measure gradient, then the synchrotron-emitting electrons must be separate from the helical field region. The presence or absence of transverse rotation-measure gradients in other sources is also discussed.
Noninvasive assessment of fetal central nervous system insult: Potential application to prenatal diagnosis

We have developed novel methods for isolating fetal central nervous system (CNS)‐derived extracellular vesicles (FCEs) from maternal plasma as a non‐invasive platform for testing aspects of fetal neurodevelopment in early pregnancy. We investigate the hypothesis that levels of defined sets of functional proteins in FCEs can be used to detect abnormalities in fetal neuronal and glial proliferation, differentiation, and survival.
Posterior parietal cortex activity reflects the significance of others' actions during natural viewing

The posterior parietal cortex (PPC) has been associated with multiple stimulus‐driven (e.g., processing stimulus movements, providing visual signals for the motor system), goal‐directed (e.g., directing visual attention to a target, processing behavioral priority of intentions), and action‐related functions in previous studies with non‐naturalistic paradigms. Here, we examined how these functions reflect PPC activity during natural viewing. Fourteen healthy volunteers watched a re‐edited movie during functional magnetic resonance imaging (fMRI). Participants separately annotated behavioral priority (accounting for percepts, thoughts, and emotions) they had experienced during movie episodes. Movements in the movie were quantified with computer vision and eye movements were recorded from a separate group of subjects. Our results show that while overlapping dorsomedial PPC areas respond to episodes with multiple types of stimulus content, ventrolateral PPC areas exhibit enhanced activity when viewing goal‐directed human hand actions. Furthermore, PPC activity related to viewing goal‐directed human hand actions was more accurately explained by behavioral priority than by movements of the stimulus or eye movements. Taken together, our results suggest that PPC participates in perception of goal‐directed human hand actions, supporting the view that PPC has a special role in providing visual signals for the motor system (“how”), in addition to processing visual spatial movements (“where”). Hum Brain Mapp 35:4767–4776, 2014. © 2014 Wiley Periodicals, Inc.
Quantifying habitat selection and variability in habitat suitability for juvenile white sharks

While adult white sharks (Carcharodon carcharias) are apex predators with a circumglobal distribution, juvenile white sharks (JWS) feed primarily on bottom dwelling fishes and tend to be coastally associated. Despite the assumedly easier access to juveniles compared to large, migratory adults, limited information is available on the movements, environments, and distributions of individuals during this life stage. To quantify movement and understand their distribution in the southern California Bight, JWS were captured and fitted with dorsal fin-mounted satellite transmitters (SPOT tags; n = 18). Nine individuals crossed the U.S. border into Baja California, Mexico. Individuals used shallow habitats (134.96 ± 191.1 m) close to shore (7.16 ± 5.65 km). A generalized linear model with a binomial distribution was used to predict the presence of individuals based on several environmental predictors from these areas. Juveniles were found to select shallow habitats (< 1000 m deep) close to land (< 30 km of the shoreline) in waters ranging from 14 to 24°C. Southern California was found to be suitable eight months of the year, while coastal habitats in Baja California were suitable year-round. The model predicted seasonal movement with sharks moving from southern California to Baja California during winter. Additionally, habitat distribution changed inter-annually with sharks having a more northerly distribution during years with a higher Pacific Decadal Oscillation index, suggesting sharks may forego their annual fall migrations to Baja California, Mexico, during El Niño years. Model predictions aligned with fishery-dependent catch data, with a greater number of sharks being captured during periods and/or areas of increased habitat suitability. Thus, habitat models could be useful for predicting the presence of JWS in other areas, and can be used as a tool for potentially reducing fishery interactions during seasons and locations where there is increased susceptibility of incidental catch.
Hospital-Based Study of Epithelial Malignancies of Endometrial Cancer Frequency in Lahore, Pakistan, and Common Diagnostic Pitfalls

The current study was conducted to see the frequency of epithelial malignancies of endometrium with focus on the common diagnostic pitfalls and identify morphological and immunohistochemical markers helpful in the differential diagnosis between different subtypes. It is a retrospective descriptive study carried out on 52 specimens of endometrial tumors received in Fatima Memorial Hospital, Lahore, Pakistan, during three years (2010–2012). Patients were divided into 5 age groups: <40, 41–50, 51–60, 61–70, and >70 yrs. Tissues were fixed in 10% formalin and processed and stained with haematoxylin-eosin. Stained slides were examined to determine the histological types by WHO classification, and immunohistochemistry for WT1, p53, ER/PR, and MIB1 was done in cases where morphology alone was not helpful in making a confirmed diagnosis. 80% of specimens were of endometrioid adenocarcinomas, 11% of serous tumors, 4% of clear cell carcinoma, and 4% of squamous cell carcinomas involving both cervix and endometrium. Most of the patients (28.84%) with endometrial carcinomas fall in the age range of 51–60 yrs. Endometrioid adenocarcinoma is the most common type of epithelial endometrial malignancies. Morphology is the keystone in the evaluation of these tumors, but immunohistochemistry can also be helpful in establishing the correct diagnosis.
The Impacts of the Cruise Industry on Tourism Destinations

In this paper we describe the evolution of the cruise tourism industry and we analyze different impacts on tourism destinations of this segment of the travel industry. The study includes the discussion of economic, social, environmental, cultural and political effects. We present data to analyze and compare the performance of the main cruise destinations and cruise lines. Analysis and data are based mainly on a selection of information taken from different official worldwide reports (OMT, CTO), press releases and previous studies. The economic impact is estimated from tourist expenditure and local information. Environmental impacts are compiled from historical and current data. We also describe different activities related to the cruise ship industry to identify costs and benefits to different actors of the local economies. From the analysis, we discuss some stylized facts about the cruise ship industry and we show that some optimist evaluations of local decision makers are not completely
On-line Estimation of Diffuse Materials

Determining the reflectance properties of real materials is an important task for augmented reality applications with consistent illumination. The main application is the insertion of virtual objects with shadows with correct brightness. Moreover, for displaying real objects with user-defined materials, the original materials must be known. Many research results have shown, that a material reconstruction is possible from digital photographs. This reconstruction is often performed under laboratory conditions in a time-consuming pre-process. We present a new method for the on-line reconstruction of diffuse materials given arbitrary, time-varying illumination including soft shadows. Our method uses graphics hardware (GPU) and two high dynamic range (HDR) video cameras to record both the environment and the object.
The Yin and Yang of Processing Data Warehousing Queries on GPU Devices

Database community has made significant research efforts to optimize query processing on GPUs in the past few years. However, we can hardly find that GPUs have been truly adopted in major warehousing production systems. Preparing to merge GPUs to the warehousing systems, we have identified and addressed several critical issues in a three-dimensional study of warehousing queries on GPUs by varying query characteristics, software techniques, and GPU hardware configurations. We also propose an analytical model to understand and predict the query performance on GPUs. Based on our study, we present our performance insights for warehousing query execution on GPUs. The objective of our work is to provide a comprehensive guidance for GPU architects, software system designers, and database practitioners to narrow the speed gap between the GPU kernel execution (the fast mode) and data transfer to prepare GPU execution (the slow mode) for high performance in processing data warehousing queries. The GPU query engine developed in this work is open source to the public.
BWIBots: A platform for bridging the gap between AI and human–robot interaction research

Recent progress in both AI and robotics have enabled the development of general purpose robot platforms that are capable of executing a wide variety of complex, temporally extended service tasks in open environments. This article introduces a novel, custom-designed multi-robot platform for research on AI, robotics, and especially human–robot interaction for service robots. Called BWIBots, the robots were designed as a part of the Building-Wide Intelligence (BWI) project at the University of Texas at Austin. The article begins with a description of, and justification for, the hardware and software design decisions underlying the BWIBots, with the aim of informing the design of such platforms in the future. It then proceeds to present an overview of various research contributions that have enabled the BWIBots to better (a) execute action sequences to complete user requests, (b) efficiently ask questions to resolve user requests, (c) understand human commands given in natural language, and (d) understand human intention from afar. The article concludes with a look forward towards future research opportunities and applications enabled by the BWIBot platform.
The educational intervention "Focusing" as a strategy to stress reduction among health care workers: a pilot study in an Italian teaching hospital.

BACKGROUND An educational intervention for stress management of healthcare workers based on a mindfulness approach called Focusing in an Italian teaching hospital. METHODS In 2017 a pilot mandatory training on stress management targeted to healthcare workers was organized in the 447 bed teaching hospital Sant'Andrea in Rome. We implemented a mindfulness intervention called Focusing. Training with an adult learning approach was adopted. A mixed model using quantitative and qualitative methods was used to evaluate the course's effects on stress reduction. Quantitative data were collected with the Perceived Stress Scale and data were analyzed at two different time points: pre-intervention and post-intervention. Qualitative data were collected via a focus group interview at the end of the course. RESULTS A total of 20 healthcare workers participated in the course and was divided in 2 groups: 7 physicians and 13 nurses. 15 (75%) were women and ages ranged from 31 to 56 (median age 46,5 years). 5 (25%) were men and ages ranged from 39 to 54 (median age 47 years). Perceived stress decreased with significant change (P=,0195) from 21,4 +/- 4,4 at baseline to 17,5 +/- 6.18 at the end of the course. The major changes the participants noted in their focus group were a greater sense of calmness, enhanced emotional self-regulation, improved coping, increased mental clarity and a sense of empowerment in dealing with the fear, anxiety, and other issues related to their work. CONCLUSIONS Our initial aim was to investigate whether the course, based on improve of self-empathy by Focusing, could help healthcare workers face the negative effects of stress. There was a significant reduction in perceived stress and qualitative results showed an improvement in reactivity to inner experience and a more attentive perception of internal and external experiences.
Optimizing Krylov Subspace Solvers on Graphics Processing Units

Krylov subspace solvers are often the method of choice when solving sparse linear systems iteratively. At the same time, hardware accelerators such as graphics processing units (GPUs) continue to offer significant floating point performance gains for matrix and vector computations through easy-to-use libraries of computational kernels. However, as these libraries are usually composed of a well optimized but limited set of linear algebra operations, applications that use them often fail to leverage the full potential of the accelerator. In this paper we target the acceleration of the BiCGSTAB solver for GPUs, showing that significant improvement can be achieved by reformulating the method and developing application-specific kernels instead of using the generic CUBLAS library provided by NVIDIA. We propose an implementation that benefits from a significantly reduced number of kernel launches and GPU-host communication events, by means of increased data locality and a simultaneous reduction of multiple scalar products. Using experimental data, we show that, depending on the dominance of the untouched sparse matrix vector products, significant performance improvements can be achieved compared to a reference implementation based on the CUBLAS library. We feel that such optimizations are crucial for the subsequent development of high-level sparse linear algebra libraries.
How Effective are Online Reputation Mechanisms? An Experimental Study

Electronic reputation or "feedback" mechanisms aim to mitigate the moral hazard problems associated with exchange among strangers by providing the type of information available in more traditional close-knit groups, where members are frequently involved in one another's dealings. In this paper, we compare trading in a market with online feedback (as implemented by many Internet markets) to a market without feedback, as well as to a market in which the same people interact with one another repeatedly (partners market). We find that while the feedback mechanism induces quite a substantial improvement in transaction efficiency, it also exhibits a kind of public goods problem in that, unlike in the partners market, the benefits of trust and trustworthy behavior go to the whole community and are not completely internalized. We discuss the implications of this perspective for improving feedback systems.
Active Learning with Mixed Query Types in Learning from Demonstration

Active Learning (AL) has recently drawn a lot of attention within the Learning from Demonstration (LfD) community. We are particularly interested in the potential of AL to significantly improve the efficiency of learning new skills from human demonstrators. In this paper we review the different types of queries proposed in the AL literature and exemplify how they can be applied to LfD problems. We also discuss the factors that affect query selection in a mixed querytype scenario.
A UNIFIED FRAMEWORK FOR INTEREST MANAGEMENT AND DYNAMIC LOAD BALANCING IN DISTRIBUTED SIMULATION

The paper discusses the distributed simulation of systems w ith large shared state and addresses issues related to interest management and dynamic load balancing. It identifies the efficie nt partitioning and distribution of the shared state as a key pr oblem in such simulations and discusses a hierarchical multilevel interest management scheme which facilitates dynami c
10-Year Overview of the Hospital-Based Prevalence and Treatment of Congenital Cataracts: The CCPMOH Experience

A review of 6 years of hospitalization charts from Zhongshan Ophthalmic Center (ZOC) revealed that congenital cataracts (CC) accounted for 2.39% of all cataract in-patient cases and that the age at surgery was decreasing before the establishment of the Childhood Cataract Program of the Chinese Ministry of Health (CCPMOH) in December 2010. We aimed to investigate data from the 4 years (January 2011 to December 2014) following the establishment of the CCPMOH, compared, and combined with data from the previous study period (January 2005 to December 2010) to generate a 10-year overview of the hospital-based prevalence and treatment of CC. In the 4-year period after CCPMOH establishment, the prevalence of CC was 2.01% in all hospitalizations, and was 2.78% in all cataract in-patients. Most of the eligible CC in-patients (71%) lived in south China. The ratio of boys to girls was 1.42:1. Nearly 2/3 of the patients underwent cataract extraction with primary intraocular lens (IOL) implantation at a mean age of 78.40±51.45 months, and cataract extraction surgeries without IOL implantation were performed in the remaining 1/3 of patients at a mean age of 10.03±15.92 months. After CCPMOH establishment, an increased incidence of CC was revealed, and the CC in-patients were younger than the patients in the previous period. The 10-year overview (2421 CC in-patients from 206630 hospitalizations) revealed upward trends in both the number and the prevalence of CC and a further reduction in age at surgery. In conclusion, the data from 4-year period after CCPMOH establishment and the 10-year overview showed upward trends in the hospital-based prevalence of CC cases and a further reduction in age at surgery, likely reflecting the effects of the CCPMOH establishment and providing useful information for further CC studies and a valuable foundation for the prevention and treatment of this cause of childhood blindness.