Miracle-dz/UniFAR-FTUs huggingface dataset:
FALSE-NEGATIVE RESULTS IN SCREENING PROGRAMS

Objectives: Assessment of the appropriateness of screening programs involves consideration of the harms as well as the benefits. These harms include the risk of false-negative results, the consequences of which have remained underinvestigated. This paper reports the results of a systematic literature review that aimed to assess the medical psychological, economic, and legal consequences of false-negative results in national screening programs. Methods: The review included a comprehensive literature search and contact with experts to identify relevant literature. Most studies that were identified presented only anecdotal evidence. However, thirteen studies presented quantitative information on medical consequences of false negatives, eight studies presented information on psychological consequences, and two studies presented information on economic consequences. Results: The strength of evidence from most of the primary studies was low. There is some evidence, however, that false-negative results may have a large legal impact. There is also a consensus in the literature that false negatives may have a negative impact on public confidence on screening; evidence is however limited. Conclusions: False negatives are evident even in high-quality screening programs. They may have the potential to delay the detection of breast and cervical cancer, but there is little evidence to help in assessing their psychological consequences. They also may lead to legal action being taken by those affected and may reduce public confidence in screening. Their impact may be reduced by provision of full information to participants about the benefits and limitations of screening programs and by increasing public education on these issues.
Life Satisfaction Differences between Workers and Non-Workers - The Value of Participation per se

Is working more than monetary income? This paper attempts to give an answer to this question on the basis of the German Socio-economic Panel data set. By comparing the satisfaction with life between workers and non-workers with the same household income, the monetary value of participating in the labour force is assessed. It is found that this monetary value is substantial for many individuals and that it varies strongly with personal characteristics such as age and gender.Women suffer less than men when loosing their job. Individuals about 65 and over do not seem to attach much value to working besides the income it generates.
DISCRETENESS WITHOUT SYMMETRY BREAKING: A THEOREM

This paper concerns random sprinklings of points into Minkowski spacetime (Poisson processes). It proves that there exists no equivariant measurable map from sprinklings to spacetime directions (even locally). Therefore, if a discrete structure is associated to a sprinkling in an intrinsic manner, then the structure will not pick out a preferred frame, locally or globally. This implies that the discreteness of a sprinkled causal set will not give rise to "Lorentz breaking" effects like modified dispersion relations. Another consequence is that there is no way to associate a finite-valency graph to a sprinkling consistently with Lorentz invariance.
Anti-carcinogenic activity of anandamide on human glioma in vitro and in vivo

The poor prognosis of gliomas is to a large extent attributed to the markedly proliferative and invasive nature of the disease. Endocannabinoids have emerged as novel potential anti-tumor agents. The present study aimed to investigate the anti-carcinogenic activity of anandamide (AEA), an endocannabinoid, on glioma cells. To assess the functional role of AEA in glioma, the effects of AEA on cell proliferation, migration, invasion, apoptosis and the cell cycle in vitro, and tumor growth in vivo, were investigated. AEA markedly inhibited the proliferation of U251 cells in a dose- and time-dependent manner. Flow cytometric assays revealed that the apoptosis rate of U251 cells upon treatment with AEA was increased. AEA also suppressed the adhesion, migration and invasion capabilities of the U251 cells. Furthermore, AEA inhibited tumor growth in vivo. These results highlighted the potential role of AEA in the tumorigenesis and progression of glioma, and suggested that AEA exhibits therapeutic potential in the management of human glioma.
Transcriptional control of the Saccharomyces cerevisiae PGK gene by RAP1

The promoter of the yeast glycolytic gene encoding phosphoglycerate kinase (PGK) contains an upstream activation sequence between bases -538 and -402 upstream of the initiating ATG. The upstream activation sequence contains multiple functional elements, including an essential region called the activator core (AC) sequence and three copies of the pentamer 5'-CTTCC-3'. The AC sequence shows strong homology to the consensus binding sites for the yeast proteins RAP1 (GRF1) and TUF. We have demonstrated that the yeast protein which interacts with the AC sequence is the DNA-binding protein RAP1. Expression of the PGK gene is found to be regulated according to the carbon source in the growth medium. PGK mRNA levels are high in yeast cells grown in glucose medium but low in yeast cells grown in media containing carbon sources such as pyruvate and acetate. This carbon source regulation of transcription was found to be mediated, in part, via regulation of RAP1 binding to the AC sequence. The promoters of many other yeast glycolytic genes also contain consensus RAP1-binding sites and copies of the CTTCC pentamer. This suggests that RAP1 may be involved in transcriptional control of many other glycolytic genes in addition to the PGK gene.
Depletion of gentamicin in the milk of Holstein cows after single and repeated intramammary and parenteral treatments.

Twenty-four healthy Holstein cows, 2.72 +/- 0.64 (mean +/- SD) years old, weighing 603.96 +/- 73.22 kg (mean +/- SD), and representing various levels of milk production, were used to determine the depletion of gentamicin (GT) in milk. The cows had not received antibiotics or other drugs that could interfere with study for at least 60 days before the beginning of the investigation. The cows were divided into six groups (n = 4) and treated with single (treatments A, B and C) or repeated (treatments D, E and F) doses of GT. Cows were acclimated for 7 days before administration of GT and milked twice a day at 12-h intervals (06.00 hours, 18.00 hours) throughout the duration of the study. Control milk samples were obtained after the arrival of the cows and assayed to establish their GT free status. On day 1 of each treatment, a baseline milk sample was collected from the milk produced (06.00 hours) by each cow. A single dose of GT was administered intramammarily (A, i.m.m. left front quarter, 500 mg), intravenously (B, i.v., 5 mg/kg body weight) or intramuscularly (C, i.m., 5 mg/kg body weight). Cows in treatments D (i.m.m., 500 mg), E (i.v., 5 mg/kg body weight) and F (simultaneous i.m.m. 500 mg plus i.v. 5 mg/kg body weight) were treated twice a day for 5 consecutive days just after the morning and evening milkings. Milk samples from individual cows were collected every day after each milking during and after dosing until GT concentration in the milk was below the safe level of < or = 30 ng/mL. The concentration of GT in milk was determined by a high-performance liquid chromatographic procedure. Depletion of GT to a concentration < or = 30 ng/mL occurred at the seventh (84 h), third (36 h), third (36 h), eleventh (132 h) third (36 h) and nineteenth (228 h) post-dosing milking, for cows in treatments A, B, C, D, E and F respectively. The highest mean +/- SEM) concentrations of GT were 14 710 +/- 1213.89, 167.87 +/- 46.94 and 91.62 +/- 14.55 ng/mL measured in the first milking post dosing (12 h) for cows in treatment A, B and C respectively; for cows in treatments D, E and F, during the dosing period, they were 14067.50 +/- 2989.09, 446.07 +/- 100.92, and 22900 +/- 2843.66 ng/mL and occurred at the seventh, third and eighth milking respectively. Because GT is not approved for use in dairy cattle and because of the long depletion time associated with some possible treatments, illegal and extra-label use is likely to cause residues in milk.
BMP‐4 affects the differentiation of metanephric mesenchyme and reveals an early anterior‐posterior axis of the embryonic kidney

Bone morphogenetic protein‐4 (BMP‐4), a member of the transforming growth factor‐β (TGF‐β) family, regulates several developmental processes during animal development. We have now studied the effects of BMP‐4 in the metanephric kidney differentiation by using organ culture technique. Human recombinant BMP‐4 diminishes the number of ureteric branches and changes the branching pattern. Our data suggest that BMP‐4 affects the ureteric branching indirectly via interfering with the differentiation of the nephrogenic mesenchyme. The clear positional preference of the defects to posterior mesenchyme might reflect an early anterior‐posterior patterning of the metanephric mesenchyme. The smooth muscle α‐actin expressing cell population around the ureteric stalk, highly expressing Bmp‐4 mRNA, is also expanded in kidneys treated with BMP‐4. Thus, BMP‐4 may be a physiological regulator of the development of the periureteric smooth muscle layer and ureteric elongation. Dev Dyn;217:146–158. © 2000 Wiley‐Liss, Inc.
Southern Hemisphere humpback whales wintering off Central America: insights from water temperature into the longest mammalian migration

We report on a wintering area off the Pacific coast of Central America for humpback whales (Megaptera novaeangliae) migrating from feeding areas off Antarctica. We document seven individuals, including a mother/calf pair, that made this migration (approx. 8300 km), the longest movement undertaken by any mammal. Whales were observed as far north as 11° N off Costa Rica, in an area also used by a boreal population during the opposite winter season, resulting in unique spatial overlap between Northern and Southern Hemisphere populations. The occurrence of such a northerly wintering area is coincident with the development of an equatorial tongue of cold water in the eastern South Pacific, a pattern that is repeated in the eastern South Atlantic. A survey of location and water temperature at the wintering areas worldwide indicates that they are found in warm waters (21.1–28.3°C), irrespective of latitude. We contend that while availability of suitable reproductive habitat in the wintering areas is important at the fine scale, water temperature influences whale distribution at the basin scale. Calf development in warm water may lead to larger adult size and increased reproductive success, a strategy that supports the energy conservation hypothesis as a reason for migration.
Why approximate when you can get the exact? Optimal targeted viral marketing at scale

One of the most central problems in viral marketing is Influence Maximization (IM), which finds a set of k seed users who can influence the maximum number of users in online social networks. Unfortunately, all existing algorithms to IM, including the state of the art SSA and IMM, have an approximation ratio of (1 − 1/e − ε). Recently, a generalization of IM, Cost-aware Target Viral Marketing (CTVM), asks for the most cost-effective users to influence the most relevant users, has been introduced. The current best algorithm for CTVM has an approximation ratio of (1 − 1/√e − ε). In this paper, we study the CTVM problem, aiming to optimally solve the problem. We first highlight that using a traditional two stage stochastic programming to exactly solve CTVM is not possible because of scalability. We then propose an almost exact algorithm TIPTOP, which has an approximation ratio of (1 — ε). This result significantly improves the current best solutions to both IM and CTVM. At the heart of TIPTOP lies an innovative technique that reduces the number of samples as much as possible. This allows us to exactly solve CTVM on a much smaller space of generated samples using Integer Programming. While obtaining an almost exact solution, TIPTOP is very scalable, running on billion-scale networks such as Twitter under three hours. Furthermore, TIPTOP lends a tool for researchers to benchmark their solutions against the optimal one in large-scale networks, which is currently not available.
An Analog-Assisted Tri-Loop Digital Low-Dropout Regulator

This paper presents an analog-assisted (AA) output-capacitor-free digital low-dropout (D-LDO) regulator with tri-loop control. For responding to instant load transients, the proposed high-pass AA loop momentarily adjusts the unit current of the power switch array, and significantly reduces the voltage spikes. In the proposed D-LDO, the overall 512 output current steps are divided into three sub-sections controlled by coarse/fine loops with carry-in/out operations. Therefore, the required shift register (SR) length is reduced, and a 9-bit output current resolution is realized by using only 28-SR bits. Besides, the coarse-tuning loop helps to reduce the recovery time, while the fine-tuning loop improves the output accuracy. To eliminate the limit cycle oscillation and reduce the quiescent current, a freeze mode is added after the fine-tuning operation. To reduce the output glitches and the recovery time, a nonlinear coarse word control is designed for the carry-in/out operations. The D-LDO is fabricated in a 65-nm general purpose CMOS process. A maximum voltage undershoot/overshoot of 105 mV is measured with a 10-mA/1-ns load step and a total capacitor of only 100 pF. Thus, the resulting figure-of-merit is 0.23 ps.
Visual Positions of Links and Clicks on Wikipedia

In this work, we study the visual position of links and their clicks on Wikipedia, particularly where links are visually located, at which screen positions users click on links, and which areas on the screen exhibit more or less clicks per links. For that purpose, we introduce a novel dataset containing the on-screen coordinate position for all links between pages in the English Wikipedia and additionally resort to navigation logs of Wikipedia users. Using this data, we can observe a preference of certain link and click locations on Wikipedia including first evidence of positional click bias. For example, our results suggest that users have a tendency to prefer to click on the left side of the screen which exceeds what one would expect from the presence of links on pages. We believe that presented data and research can be useful for optimizing the process of link creation and link consumption on Wikipedia and other Web platforms.
Bacteriological Assessment of the Indoor Air of Different Hospitals of Kathmandu District

Nosocomial infection is the infection that has been caught in a hospital and is potentially caused by organisms that are not susceptible to antibiotics. Nosocomial infections are transmitted directly or indirectly through air and may cause different types of infections. This study was undertaken with an objective to determine the prevalence of nosocomial bacteria present in hospital indoor environment. A total of 16 air samples were taken from general wards and emergency wards of 8 different hospitals using an impactor air sampler in nutrient agar, mannitol salt agar, blood agar, cetrimide agar, and MacConkey agar. The bacteriological agents were isolated and identified by cultural characteristics, Gram staining, and biochemical tests, and their antibiotic susceptibility pattern was determined using CLSI Guideline, 2015. According to the European Union Guidelines to Good Manufacturing Practices, the hospitals were under C- and D-grade air quality. According to the European Commission, most of the hospitals were intermediately polluted. Out of 16 indoor air samples, 47.18% of Staphylococcus aureus and 1.82% Pseudomonas spp. were isolated. CoNS, Streptococcus spp. , Micrococcus spp. , and Bacillus spp. and Gram-negative bacteria E.coli and Proteus spp. were identified. The bacterial load was found to be high in the emergency ward (55.8%) in comparison to that in the general ward (44.2%). There is statistically no significant difference between bacterial load and 2 wards (general and emergency) of different hospitals and among different hospitals. The most effective antibiotic against S. aureus was gentamicin (81.81%) and ofloxacin (81.81%). Among the antibiotics used for Pseudomonas spp. , ceftriaxone (83.3%) and ofloxacin (83.3%) were effective. High prevalence of S. aureus and Gram-negative bacteria was found in this study; it is therefore important to monitor air quality regularly at different hospitals to prevent HAI.
Object-related activity revealed by functional magnetic resonance imaging in human occipital cortex.

The stages of integration leading from local feature analysis to object recognition were explored in human visual cortex by using the technique of functional magnetic resonance imaging. Here we report evidence for object-related activation. Such activation was located at the lateral-posterior aspect of the occipital lobe, just abutting the posterior aspect of the motion-sensitive area MT/V5, in a region termed the lateral occipital complex (LO). LO showed preferential activation to images of objects, compared to a wide range of texture patterns. This activation was not caused by a global difference in the Fourier spatial frequency content of objects versus texture images, since object images produced enhanced LO activation compared to textures matched in power spectra but randomized in phase. The preferential activation to objects also could not be explained by different patterns of eye movements: similar levels of activation were observed when subjects fixated on the objects and when they scanned the objects with their eyes. Additional manipulations such as spatial frequency filtering and a 4-fold change in visual size did not affect LO activation. These results suggest that the enhanced responses to objects were not a manifestation of low-level visual processing. A striking demonstration that activity in LO is uniquely correlated to object detectability was produced by the "Lincoln" illusion, in which blurring of objects digitized into large blocks paradoxically increases their recognizability. Such blurring led to significant enhancement of LO activation. Despite the preferential activation to objects, LO did not seem to be involved in the final, "semantic," stages of the recognition process. Thus, objects varying widely in their recognizability (e.g., famous faces, common objects, and unfamiliar three-dimensional abstract sculptures) activated it to a similar degree. These results are thus evidence for an intermediate link in the chain of processing stages leading to object recognition in human visual cortex.
A simplified approach to minimally invasive parathyroidectomy

To assess the feasibility of a simplified approach for the use of a rapid intraoperative parathyroid hormone (IOPTH) assay based on a single 10‐minute post‐excision level using the workup parathyroid hormone level (wPTH) as the baseline in minimally invasive parathyroidectomy (MIP) and to compare the predictive value of this criterion with other recommended criteria.
Quantitative assessment of the left atrial myocardial deformation in patients with chronic mitral regurgitation by strain and strain rate imaging: an observational study.

OBJECTIVE We evaluated regional left atrial (LA) myocardial deformations by strain (S) and strain rate (SR) imaging during LA pump, reservoir, and conduit phases in patients with chronic rheumatic mitral regurgitation (MR). METHODS This cross-sectional observational study included 42 patients with moderate-to-severe MR who had normal left ventricular (LV) function, and 36 healthy control subjects. Conventional echocardiographic data were used to calculate LV and LA dimensions, volumes and functional indices (LA ejection fraction, LA active and passive emptying fraction). Longitudinal S/SR indices of the mid and superior segments of LA walls were measured during the three LA phases. Student t-test, Mann-Whitney U test, Chi-square test and Bland-Altman analysis were used for statistical analysis. RESULTS LV systolic functions were similar in the patient and control groups. LV diameters, LA diameters and LA volumes were greater in the patient group compared with the control group (p<0.05, p<0.001, and p<0.001). LA ejection fraction and LA active emptying fraction values were lower in the patient group than in the control group (56 ± 7 vs. 63 ± 5%, 33 ± 9 vs. 40 ± 4%, p<0.05 for both). During the three LA phases, longitudinal S/SR values were significantly lower in all the segments in the patient group compared with the control group (p<0.001 for S, p<0.001 and p<0.05 for SR). CONCLUSION Regional LA longitudinal myocardial deformations are observed to be impaired during all the mechanical phases in patients with moderate-to-severe MR. Volume overload, remodeling and rheumatic effects may be responsible for the LA myocardial dysfunction in these patients.
A robust approach for process variation aware mask optimization

As the minimum feature size continues to shrink, whereas the wavelength of light used for lithography remains constant, Resolution Enhancement Techniques are widely used to optimize mask, so as to improve the subwavelength printability. Besides correcting for error between the printed image and target shape, a mask optimization method also needs to consider process variation. In this paper, a robust mask optimization approach is proposed to optimize the process window as well as the Edge Placement Error (EPE) of the printed image. Experiments results on the public benchmarks are encouraging.
1-Methylpiperazine-1,4-diium dipicrate

In the crystal structure of the title compound [systematic name: 1-methylpiperazine-1,4-diium bis(2,4,6-trinitrophenolate)], C5H14N2 2+·2C6H2N3O7 −, the ionic components are connected by relatively strong N—H⋯O hydrogen bonds into centrosymmetric six-membered conglomerates, which comprise two dications and four anions. Besides Coulombic interactions, only weak C—H⋯O interactions and some stacking between picrates (separation between the planes of ca. 3.4 Å but only a small overlapping) can be identified between these ‘building blocks’ of the crystal structure. The piperazine ring adopts a chair conformation with the methyl substituent in the equatorial position. In the picrate anions, the twist angles of the nitro groups depend on their positions relative to the phenolate O atom: it is much smaller for the NO2 groups para to the C—O− group [15.23 (9)and 3.92 (14)°] than for the groups in the ortho positions [28.76 (13)–39.84 (11)°].
Carotid Atheromatosis in Nondiabetic Renal Transplant Recipients: The Role of Prediabetic Glucose Homeostasis Alterations

Background. Prediabetic glucose homeostasis alterations are important cardiovascular risk factors but their role in renal transplant recipients (RTR) has not been established. Methods. In 172 RTRs without pretransplant or de novo diabetes, we measured carotid intima media thickness (c-IMT) and performed an oral glucose tolerance test (OGTT). Results. In multivariate analysis, age, hypertension and male sex were independently associated with a c-IMT in the third tertile. A significant interaction between gender and glucose homeostasis parameters was observed. Among male RTR, those with a c-IMT in the third tertile showed significantly higher plasma glucose and HbA1c levels (5±0.5% vs. 5.1±0.5% vs. 5.5±0.4%; P<0.01 tertile 3 vs. 2 or 1) than those in other tertiles. Insulin action parameters were not significantly different. The odds ratio of being in the higher c-IMT tertile was 2.9 (95% CI: 1.05–8.1) per each 1% increase of HbA1c. By contrast, glucose and HbA1c levels were not significantly different between c-IMT tertiles in female RTR. However, age-adjusted insulin levels after OGTT were higher (86±10 vs. 51.7±9.4; P=0.02) and the insulin sensitivity index lower (0.8±0.3 vs. 0.048±0.03; P=0.04) among females in the third tertile as compared to the first one. Conclusion. Prediabetic glucose homeostasis alterations in RTRs are related to carotid atherosclerosis, although there may be gender differences in the underlying alteration.