Miracle-dz/UniFAR-FTUs huggingface dataset:
Family decision-making to withdraw life-sustaining treatments from hospitalized patients.

BACKGROUND With a national trend toward less aggressive treatment of hospitalized terminally ill patients, families increasingly participate in decisions to withdraw life-sustaining treatment. Although prior research indicates decision making is stressful for families, there have been no psychometric reports of actual stress levels and few discussions of the reasoning used by families compared to clinicians in reaching the decision. OBJECTIVES The purpose of this study was to assess levels of family stress associated with decisions to withdraw life-sustaining treatments, to assess factors that affected stress, and to compare families and clinicians on their reasoning about the decision. METHODS Data were collected from hospital decedent charts, family members of decedents, and clinicians who cared for decedents. Data from families were collected in individual interviews, shortly after decedent death and 6 months later, using psychometric measures and semi-structured interview questions. Clinicians were interviewed once shortly following patient death. RESULTS Family stress associated with the withdraw decision was high immediately following the death of the decedent and, while it decreased over time, remained high a half a year later. Several factors affected stress; most notably, stress was highest in the absence of patient advance directives. In reaching the decision, both families and clinicians prioritized what the patient would want, although families, more strongly than clinicians, endorsed doing everything medically possible to prolong the patient's life. CONCLUSIONS Findings add compelling evidence for the power of advance directives, whether written or verbal, to reduce the stress associated with family decision-making.
Effects of workload on seat pressure while cycling with two different saddles.

INTRODUCTION Seat pressure during cycling and its relationship to urological disorders have been discussed extensively in recently published literature. The effects of exercise configuration on seat pressure, however, still have not been fully investigated. AIM This study evaluates the effects of two different pedaling workloads and two saddle designs on saddle pressure in 22 (11 men and 11 women) recreational cyclists (bicycling <2 hours per week). METHODS Seat pressure was measured in the saddle surface while pedaling at workloads of 150 and 300 W using a plain and a holed saddle model, both without any gel cushion characteristics. Analysis of variance was applied to compare seat pressure between situations. MAIN OUTCOME MEASURE Study the importance of bicycle saddle pressure. RESULTS Mean seat pressure was not different between men and women. For the plain saddle, the men's average seat pressure increased as the workload increased. Using a holed saddle, the mean pressure increased as the workload increased, regardless of gender. CONCLUSIONS The increase of workload increased the seat pressure for the subjects, with the main effects dependent on workload. The use of a holed saddle was not directly related to lesser seat pressure during cycling. Our results support our understanding of a similarity between genders related to mean seat pressure, and suggest that different workload ranges may present different results for seat pressure.
Changes observed in diabetic retinopathy: eight-year follow-up of a Spanish population

Background/aims To determine the changes in the incidence of diabetic retinopathy (DR), diabetic macular oedema (DMO) and their risk factors in a population-based study of patients with diabetes mellitus (DM) referred to our 16 Primary Health Care Areas (HCAs). Methods Prospective population-based study of a total of 15 396 Caucasian patients with DM, who represent 86.53% of the total patients with DM in our HCAs, were studied over an 8-year follow-up period. All patients were screened with a mean follow-up of 3.18±1.11 times for each patient over the 8 years. Results The yearly mean value of any DR was 8.37±2.19% (8.09%–8.99%); of advanced DR yearly mean value of 0.46±0.22% (0.03–0.78); and of DMO a yearly mean value of 2.19±0.18% (2%–2.49%). A clear increase was observed in the last 3 years, any DR increased from 8.09% in 2007 to 8.99% in 2014, and DMO from 2% in 2007 to 2.49% in 2014. These increases were more evident in some age groups. For patients with any DR aged 41–50 and 51–60 and for patients with advanced DR aged 41–50, 51–60 and 61–70, the increase was more marked, related to an increase in HbA1c values or to patients treated with insulin. Conclusions An increase in the incidence of DR and DMO was observed, especially in the younger patients aged between 31 and 70 years. This is linked to bad metabolic control of DM. Our results suggest a greater number of ocular complications in the near future, such as neovascular glaucoma, if these current findings are not addressed.
Attachment dynamics in a virtual world.

The study investigated the transfer of attachment working models onto autonomous agents in a virtual social environment (VSE). Participants from a community sample (N = 422; mean age = 29 years; mean relationship duration = 4.8 years) encountered three attachment-related key scenes in a VSE: a separation with a subsequent reunion, a conflict, and an illness. In these scenarios, participants gave instructions to the main character (the "protagonist"), who had a romantic relationship with one of the other agents (the "virtual spouse"). Recorded were numerous behaviors as well as emotions participants ascribed to the protagonist. Generally, participants' attachment styles correlated as predicted with their behavior toward the virtual spouse, with βs up to.42. Thus, the study demonstrates that internal working models are transferred to the virtual relationship. This approach opens new ways to investigate attachment-related behavior by using VSEs that allow experimental variations of the virtual partner's reactions and other situational variables.
HIGHLIGHTED TOPIC Pulmonary Physiology and Pathophysiology in Obesity Physiology of obesity and effects on lung function

Salome CM, King GG, Berend N. Physiology of obesity and effects on lung function. J Appl Physiol 108: 206–211, 2010. First published October 29, 2009; doi:10.1152/japplphysiol.00694. 2009. —In obese people, the presence of adipose tissue around the rib cage and abdomen and in the visceral cavity loads the chest wall and reduces functional residual capacity (FRC). The reduction in FRC and in expiratory reserve volume is detectable, even at a modest increase in weight. However, obesity has little direct effect on airway caliber. Spirometric variables decrease in proportion to lung volumes, but are rarely below the normal range, even in the extremely obese, while reductions in expiratory flows and increases in airway resistance are largely normalized by adjusting for lung volumes. Nevertheless, the reduction in FRC has consequences for other aspects of lung function. A low FRC increases the risk of both expiratory flow limitation and airway closure. Marked reductions in expiratory reserve volume may lead to abnormalities in ventilation distribution, with closure of airways in the dependent zones of the lung and ventilation perfusion inequalities. Greater airway closure during tidal breathing is associated with lower arterial oxygen saturation in some subjects, even though lung CO-diffusing capacity is normal or increased in the obese. Bronchoconstriction has the potential to enhance the effects of obesity on airway closure and thus on ventilation distribution. Thus obesity has effects on lung function that can reduce respiratory well-being, even in the absence of specific respiratory disease, and may also exaggerate the effects of existing airway disease.
Efficient defeasible reasoning systems

For many years, the non-monotonic reasoning community has focussed on highly expressive logics. Such logics have turned out to be computationally expensive, and have given little support to the practical use of non-monotonic reasoning. In this work we discuss defeasible logic, a less-expressive but more efficient non-monotonic logic. We report on two new implemented systems for defeasible logic: a query answering system employing a backward chaining approach, and a forward-chaining implementation that computes all conclusions. Our experimental evaluation demonstrates that the systems can deal with large theories (up to hundreds of thousands of rules). We show that defeasible logic has linear complexity, which contrasts markedly with most other non-monotonic logics and helps to explain the impressive experimental results. We believe that defeasible logic, with its efficiency and simplicity is a good candidate to be used as a modelling language for practical applications, including modelling of regulations and business rules.
Dysfunctional Long-Range Coordination of Neural Activity during Gestalt Perception in Schizophrenia

Recent theoretical and empirical research on schizophrenia converges on the notion that core aspects of the pathophysiology of the disorder may arise from a dysfunction in the coordination of distributed neural activity. Synchronization of neural responses in the β-band (15–30 Hz) and γ-band range (30–80 Hz) has been implicated as a possible neural substrate for dysfunctional coordination in schizophrenia. To test this hypothesis, we examined the electroencephalography (EEG) activity in 19 patients with a Diagnostic and Statistical Manual of Mental Disorder, edition IV criteria, diagnosis of schizophrenia and 19 healthy control subjects during a Gestalt perception task. EEG data were analyzed for phase synchrony and induced spectral power as an index of neural synchronization. Schizophrenia patients were impaired significantly in the detection of images that required the grouping of stimulus elements into coherent object representations. This deficit was accompanied by longer reaction times in schizophrenia patients. Deficits in Gestalt perception in schizophrenia patients were associated with reduced phase synchrony in the β-band (20–30 Hz), whereas induced spectral power in the γ-band (40–70 Hz) was mainly intact. Our findings suggest that schizophrenia patients are impaired in the long-range synchronization of neural responses, which may reflect a core deficit in the coordination of neural activity and underlie the specific cognitive dysfunctions associated with the disorder.
Volunteering and subjective well-being in midlife and older adults: the role of supportive social networks.

OBJECTIVE This study examined the extent to which associations between volunteering and subjective well-being (SWB) could be related to volunteers having more supportive social networks relative to nonvolunteers. METHOD The sample consisted of 561 midlife and older adults (aged 55-94 years) from the TRAnsitions In Later Life study. Multiple mediation analyses examined associations between hours spent volunteering per week; availability of social support from friends, relatives, and neighbors; positive and negative social exchanges; and SWB. RESULTS The results indicated that the higher life satisfaction and positive affect reported by those who volunteer at moderate levels (up to 7 hr per week) are related to their higher levels of positive social exchanges and greater availability of social support from friends and family, relative to nonvolunteers. Those who volunteer at higher levels (7 hr or more per week) also reported greater levels of positive affect in comparison to nonvolunteers, and this was related to their greater availability of social support from friends. Availability of support from friends accounted for the greatest proportion of the volunteering-SWB associations. DISCUSSION The findings suggest that the positive SWB associated with volunteering is related to volunteers' more extensive friend and family networks.
SENSITIVITY ANALYSIS OF NARROW-BAND PHOTONIC MICRO CAVITIES AND ARRAY WAVEGUIDES 0 ω

Coupled Cavity Waveguides (CCW) is a linear array of equally spaced identical local-defect microcavities situated within an otherwise perfect photonic crystal. Tunneling of light between adjacent microcavities forms a guiding effect, with a central frequency and bandwidth controlled by the local defect parameters and by the array spacing, respectively. In this work we develop perturbation theory to investigate sensitivity of photonic crystal micro-cavities and CCW devices to structure parameters and random inaccuracies. It is shown that the CCW appealing properties are practically not affected by random inaccuracies below a certain threshold value, and degrade significantly if the structural noise levels exceed this threshold.
Protocol for Recording Enamel Hypoplasia in Modern and Archaeological Caprine Populations

This paper outlines the first methodology for recording dental enamel hypoplasia in the high-crowned dentition of modern and archaeological caprine teeth. The method has been developed and trialed on five caprine populations from Orkney (UK); two modern populations (Shetland and North Ronaldsay breeds) and three Neolithic assemblages from the archaeological sites of Knap of Howar, Skara Brae and Holm of Papa Westray. Problems associated with differential tooth wear, as well as the presence of coronal cementum are discussed, and recommendations are given on the identification and recording of hypoplastic dental defects in caprines.
Reuse of leather shavings as a reinforcing filler for poly (vinyl alcohol)

Leather shavings, the by-products of leather industry, are usually treated by the landfill, which probably makes them hazardous to the human health and the environment due to the oxidation of the containing chromium (Cr) (III) to toxic Cr (VI). Therefore, efficient and environment-friendly reusing of leather shavings is not only of great interest but is also a huge challenge. This article reported a reuse method of leather shavings by combing two novel technologies, that is, the solid state shear milling (S3M) to mechanochemically pulverize and activate leather shavings, and the thermal processing of poly (vinyl alcohol) (PVA) to make them filled with PVA. The related mechanism, the structure, and properties of the obtained composites were investigated. The results showed that S3M method could efficiently pulverize and activate leather shavings through very strong shearing and compressing forces, promoting the formation of more hydrogen bonds and the chelation in the interfaces between PVA and leather shavings, and consequently enhancing their compatibility. In this way, PVA/leather shaving composites with pretty good performances, for example, better mechanical properties, thermal stability, and water resistance as compared with neat PVA, were obtained. This is a convenient, cost-efficient, and environment-friendly technology to recycle hazardous chrome-containing leather shavings.
Living beyond the Unanticipated Sudden Death of a Partner: A Phenomenological Study

This research project explored grief and its impact upon men and women who have experienced the sudden and unanticipated death of his or her partner. It included what grief meant to them, how it was manifested in his or her everyday lives and how his or her partner's death had impacted upon his or her relationship with themselves, with others and the world. A Husserlian phenomenological approach was used to explore the experiences of the ten women and five men whose partner had died up to five years prior to being interviewed. The need for the surviving partner to continue to participate in everyday life placed great strain upon the internal resources of the surviving partner. The surviving partner needed to reinvent him or herself, in an attempt to become independent and regain functionality, whilst dealing with the sadness and loss that they had experienced. The surviving partner discovered that a new life order emerged that included hope, optimism, planning for the future and perhaps the prospect of a new relationship. The death of a partner left the surviving partner with a loss that would always be a part of them, with the memories of his or her relationship being maintained within them that will never be replaced by somebody else. The results of this research project reinforce the need for ongoing education of the community in grief and bereavement issues in order to increase the awareness of the support needs of the bereaved person. The length of time and amount of energy required to incorporate the experience into the survivor's life, is greatly underestimated by the community, and perhaps by some of the health and caring professionals. Colonial and hospital based bereavement support services need to be established and be proactive using outreach programs, actively offering the suddenly bereaved partner and family support and information.
Reputation Management Survey

Electronic markets, distributed peer-to-peer applications and other forms of online collaboration are all based on mutual trust, which enables transacting peers to overcome the uncertainty and risk inherent in the environment. Reputation systems provide essential input for computational trust as predictions on future behaviour based on the past actions of a peer In order to analyze the maturity of current reputation systems, we compare eleven reputation systems within a taxonomy of the credibility aspects of a reputation system. The taxonomy covers three topics: 1) the creation and content of a recommendation, 2) the selection and use of recommenders, and 3) the interpretation and reasoning applied to the gathered information. Although we find it possible to form a trusted reputation management network over an open network environment, there are still many regulatory and technical obstacles to address. This survey reveals various good mechanisms and methods used, but the area still requires both a) formation of standard mechanisms and metrics for reputation system collaboration and b) standard metainformation of right granularity for evaluating the credibility of reputation information provided
Influence of neural adjustments and muscle oxygenation on task failure during sustained isometric contractions with elbow flexor muscles

This study investigated the adjustments in muscle activation and oxygenation in biceps and triceps brachii during two tasks sustained to failure at 20 and 60% of the maximal voluntary contraction (MVC) force. The tasks required participants either to push against a rigid restraint (force task) or to support an inertial load (position task) with the elbow flexor muscles. The surface EMG was recorded for biceps brachii, brachioradialis, triceps brachii and trapezius superior muscles. Muscle oxygenation of biceps and triceps brachii was measured by near‐infrared spectroscopy. The position task was briefer (404 ± 159 s) than the force task (533 ± 194 s) when performed at 20% MVC (P= 0.011), but endurance time did not differ at 60% MVC (54 ± 19 versus 64 ± 16 s, respectively; P= 0.13). Biceps brachii oxygenation decreased slightly (by ∼7%) during tasks performed at 20% MVC, whereas it dropped (−40%) for tasks sustained at 60% MVC. However, the decrease in muscle oxygenation was not a significant predictor of time to failure at the two target forces, although its contribution to muscle fatigue cannot be completely ruled out at 60% MVC. In contrast, time to failure was predicted by the increase in EMG of biceps brachii for both tasks at 20% MVC, and EMG of brachioradialis and trapezius for both tasks at 60% MVC. These results suggest that neural adjustments rather than muscle oxygenation limited the time to failure for the force and position tasks at low and high target forces.
Apomorphine in the Treatment of Parkinson's Disease

&NA; Apomorphine is a potent, nonselective, directacting dopamine‐receptor agonist. Given subcutaneously, it has a rapid onset of antiparkinsonian action qualitatively comparable to that of levodopa. Despite its long history, it was not until peripheral dopaminergic side effects could be controlled by oral domperidone that the clinical usefulness of apomorphine in Parkinson's disease began to be investigated thoroughly in the mid‐1980s. Although several routes have been tried, subcutaneous administration, either as intermittent injections or continuous infusion, is so far the best and most applied in the treatment of advanced, fluctuating Parkinson's disease. Clinical trials have shown stable efficacy with markedly reduced time spent in “off” phases as well as, for infusion therapy, reduced levodopa requirements. In the most successful cases, motor fluctuations disappear and the need for oral medication is eliminated. Adverse events are usually mild and dominated by cutaneous reactions. Neuropsychiatric side effects occur, but the influence of apomorphine on these remains controversial. Controlled long‐term clinical trials are highly warranted to reveal the full potentials of this treatment. Careful patient selection and follow‐up, where the specialized movement disorder nurse has a crucial role, are paramount for a successful long‐term outcome. Apomorphine warrants a wider application in the treatment of advanced Parkinson's disease and should be tried before more invasive interventions are considered.
Perceived performance effects of ICT in manufacturing SMEs

Purpose – The purpose of this paper is to investigate whether information and communication technologies (ICT) resources, including investment and use of specific types of ICT as well as innovative work practices, have a positive impact on several dimensions of firm performance, taking into account both direct and indirect effects and both short and long‐term effects.Design/methodology/approach – An empirical study using data from a sample of 267 Spanish manufacturing SMEs was conducted. Path analysis was used to study direct and indirect ICT impacts and OLS regression was the estimation method employed.Findings – The findings show a positive relationship between ICT adoption and all the measures of perceived performance analyzed, although the impact is not always immediate since the lag effects and length differ according to the type of ICT. Managers' perceptions of ICT impact are related to the adoption of new work practices but the effects also depend positively on the number of years since new work pr.
Paediatric tuberculosis

Children are important in the epidemiology of tuberculosis as a marker of recent disease transmission and a reservoir for the future. Once infected they have a higher risk of progressing to tuberculous disease. Chest radiography and tuberculin testing with or without tissue for culture are still the standard tools for confirming the diagnosis once this is considered. Well researched treatment protocols are available but multidrug resistant tuberculosis and coexistent HIV are a challenge. Ensuring compliance with treatment is a major concern. Controversy still surrounds the place of BCG. Advances in the molecular genetics of tuberculosis hold out the possibility of better vaccines.
Immersive Recommendation: News and Event Recommendations Using Personal Digital Traces

We propose a new user-centric recommendation model, called Immersive Recommendation, that incorporates cross-platform and diverse personal digital traces into recommendations. Our context-aware topic modeling algorithm systematically profiles users' interests based on their traces from different contexts, and our hybrid recommendation algorithm makes high-quality recommendations by fusing users' personal profiles, item profiles, and existing ratings. Specifically, in this work we target personalized news and local event recommendations for their utility and societal importance. We evaluated the model with a large-scale offline evaluation leveraging users' public Twitter traces. In addition, we conducted a direct evaluation of the model's recommendations in a 33-participant study using Twitter, Facebook and email traces. In the both cases, the proposed model showed significant improvement over the state-of-the-art algorithms, suggesting the value of using this new user-centric recommendation model to improve recommendation quality, including in cold-start situations.