Miracle-dz/UniFAR-FTUs huggingface dataset:
Three-dimensional orthogonal tile sizing problem : mathematical programming approach

We discuss in this paper the problem of finding the optimal tiling transformation of three-dimensional uniform recurrences on a two-dimensional torus/grid of distributed-memory general-purpose machines. We show that even for the simplest case of recurrences which allows for such transformation, the corresponding problem of minimizing the total running time is a non-trivial non-linear integer programming problem. For the later we derive an O(1) algorithm for finding a good approximation solution. The theoretical evaluations and the experimental results show that the obtained solution approximates the original minimum sufficiently well in the context of the considered problem. Such analytical results are of obvious interest and can be successfully used in parallelizing compilers as well as in performance tuning of parallel codes.
Deconstructing normalisation: clearing the way for inclusion

This paper considers two major movements affecting the lives of people with an intellectual disability: normalisation and inclusion. The authors look back at the normalisation movement, reviewing its aims, processes and outcomes, and explore its relationship and compatibility with inclusion. In looking forward to the realisation of the inclusion agenda they ask whether normalisation is a suitable platform on which to build inclusion, or whether a process of deconstruction is needed. They discuss what lessons can be learnt from normalisation for the inclusion movement.
Magnetocentrifugal Winds in Three Dimensions: A Nonaxisymmetric Steady State

Outflows can be loaded and accelerated to high speeds along rapidly rotating, open magnetic field lines by centrifugal forces. Whether such magnetocentrifugally driven winds are stable is a long-standing theoretical problem. As a step toward addressing this problem, we perform the first large-scale 3D MHD simulations that extend to a distance ~102 times beyond the launching region, starting from steady 2D (axisymmetric) solutions. In an attempt to drive the wind unstable, we increase the mass loading on one half of the launching surface by a factor of and reduce it by the same factor on the other half. The evolution of the perturbed wind is followed numerically. We find no evidence for any rapidly growing instability that could disrupt the wind during the launching and initial phase of propagation, even when the magnetic field of the magnetocentrifugal wind is toroidally dominated all the way to the launching surface. The strongly perturbed wind settles into a new steady state, with a highly asymmetric mass distribution. The distribution of magnetic field strength is, in contrast, much more symmetric. We discuss possible reasons for the apparent stability, including stabilization by an axial poloidal magnetic field, which is required to bend field lines away from the vertical direction and produce a magnetocentrifugal wind in the first place.
Recognition of distress and psychiatric morbidity in cancer patients: a multi-method approach.

BACKGROUND This study aimed to determine the prevalence of psychiatric morbidity and distress among 189 consecutively recruited cancer patients upon admission to surgical oncology wards, and to investigate the recognition of distressed patients by medical staff. PATIENTS AND METHODS Assessment consisted of a diagnostic psychiatric interview (SCID, DSM-IV), patient-reported distress using a standardised questionnaire (Hospital Anxiety and Depression Scale), and physicians' and nurses' estimates of patients' distress. Twenty-eight per cent of patients were assigned a psychiatric diagnosis, with adjustment disorder predominating. RESULTS Surgeons accurately recognised marked distress in 77% of patients with a psychiatric disorder and nurses did so in 75%. Because of low specificity, the positive predictive value was only 39% in surgeons and 40% in nurses. However, recognition of distress translated into referral to the psychosocial liaison service for only a minor proportion of distressed patients. CONCLUSIONS Since a remarkable proportion of distressed patients remained unrecognised by the medical staff, only systematic screening of patients upon admission allows timely support to those who are most in need.
Infants Detect Patterns of Choices Despite Counter Evidence, but Timing of Inconsistency Matters

ABSTRACT Understanding others’ preference for a relational category of objects (e.g., prefer darker colored shirts) can be challenging for young children, as it involves comparison of choice options within and across exemplars. Adding to the challenge is occasional inconsistency in choices made by others. Here the authors examined whether 14-month-olds could detect an experimenter’s preference for taller objects when they observed choices that were somewhat inconsistent. Infants watched four familiarization events involving different object pairs: The experimenter chose the taller of two objects thrice and the shorter object once—the inconsistent choice was presented at different time points of familiarization. The infants detected the experimenter’s preference for taller objects only when they had observed three consistent choices consecutively from the beginning. This finding is in line with relational learning, specifically the significant role of initial data in the extraction of relational commonality. It also connects to the hierarchical Bayesian models of rational learning: Inconsistency can be discounted when the initial data allow learners to distinguish a highly probable hypothesis.
Behaviors and Energy Source of Mycoplasma gallisepticum Gliding

Mycoplasmas, the smallest bacteria, are parasitic and occasionally commensal. Mycoplasma gallisepticum is related to human-pathogenic mycoplasmas—Mycoplasma pneumoniae and Mycoplasma genitalium—which cause so-called “walking pneumonia” and nongonococcal urethritis, respectively. These mycoplasmas trap sialylated oligosaccharides, which are common targets among inﬂuenza viruses, on host trachea or urinary tract surfaces and glide to enlarge the infected areas. Interestingly, this gliding motility is not related to other bacterial motilities or eukaryotic motilities. Here, we quantitatively analyze cell behaviors in gliding and clarify the direct energy source. The results provide clues for elucidating this unique motility mechanism. ABSTRACT Mycoplasma gallisepticum, an avian-pathogenic bacterium, glides on host tissue surfaces by using a common motility system with Mycoplasma pneumoniae. In the present study, we observed and analyzed the gliding behaviors of M. gallisepticum in detail by using optical microscopes. M. gallisepticum glided at a speed of 0.27 ± 0.09 μm/s with directional changes relative to the cell axis of 0.6 degree ± 44.6 degrees/5 s without the rolling of the cell body. To examine the effects of viscosity on gliding, we analyzed the gliding behaviors under viscous environments. The gliding speed was constant in various concentrations of methylcellulose but was affected by Ficoll. To investigate the relationship between binding and gliding, we analyzed the inhibitory effects of sialyllactose on binding and gliding. The binding and gliding speed sigmoidally decreased with sialyllactose concentration, indicating the cooperative binding of the cell. To determine the direct energy source of gliding, we used a membrane-permeabilized ghost model. We permeabilized M. gallisepticum cells with Triton X-100 or Triton X-100 containing ATP and analyzed the gliding of permeabilized cells. The cells permeabilized with Triton X-100 did not show gliding; in contrast, the cells permeabilized with Triton X-100 containing ATP showed gliding at a speed of 0.014 ± 0.007 μm/s. These results indicate that the direct energy source for the gliding motility of M. gallisepticum is ATP. IMPORTANCE Mycoplasmas, the smallest bacteria, are parasitic and occasionally commensal. Mycoplasma gallisepticum is related to human-pathogenic mycoplasmas—Mycoplasma pneumoniae and Mycoplasma genitalium—which cause so-called “walking pneumonia” and nongonococcal urethritis, respectively. These mycoplasmas trap sialylated oligosaccharides, which are common targets among inﬂuenza viruses, on host trachea or urinary tract surfaces and glide to enlarge the infected areas. Interestingly, this gliding motility is not related to other bacterial motilities or eukaryotic motilities. Here, we quantitatively analyze cell behaviors in gliding and clarify the direct energy source. The results provide clues for elucidating this unique motility mechanism.
Paper/Pencil Versus Online Data Collection

Abstract Usage of online data-collection methods are increasing in leisure research. Some potential benefits to using online methods over traditional paper/pencil techniques include financial savings and easier access to large populations. Disadvantages, however, include difficulty in sample selection and variations of the instruments' reliability. This study explores how subject responses potentially differ when collecting data online versus paper/pencil for six instruments commonly used within leisure research. A repeated measure design with paired sample t-tests and HLM was used with 207 college students to compare these methods of data collection. Responses differed between methods on three of the tested instruments. A general pattern was found suggesting participants perceived their anonymity was better protected when completing online questionnaires.
Revisiting the evaluation of defect prediction models

Defect Prediction Models aim at identifying error-prone parts of a software system as early as possible. Many such models have been proposed, their evaluation, however, is still an open question, as recent publications show. An important aspect often ignored during evaluation is the effort reduction gained by using such models. Models are usually evaluated per module by performance measures used in information retrieval, such as recall, precision, or the area under the ROC curve (AUC). These measures assume that the costs associated with additional quality assurance activities are the same for each module, which is not reasonable in practice. For example, costs for unit testing and code reviews are roughly proportional to the size of a module. In this paper, we investigate this discrepancy using optimal and trivial models. We describe a trivial model that takes only the module size measured in lines of code into account, and compare it to five classification methods. The trivial model performs surprisingly well when evaluated using AUC. However, when an effort-sensitive performance measure is used, it becomes apparent that the trivial model is in fact the worst.
Community Therapist Reports of Client Engagement Challenges During the Implementation of Multiple EBPs in Children’s Mental Health

ABSTRACT This study investigated therapist reports of client engagement challenges in delivering evidence-based practices (EBPs), within the context of a large-scale implementation of multiple practices in children’s mental health services. Data were drawn from an online survey of 668 therapists (88% female, 35.0% Non-Hispanic White). The majority of therapists (75.4%) endorsed at least one client engagement challenge during their implementation of an EBP with an identified client over the previous two months. Two types of EBP client engagement challenges with distinct correlates but similar overall frequencies could be readily differentiated – Expressed Client Concerns and Limited Client Engagement in therapy activities. Limited Client Engagement were more commonly reported for clients with externalizing problems and by therapists with higher emotional exhaustion and negative perceptions of the specific EBP being delivered, whereas Hispanic/Latino therapists were less likely to report Limited Client Engagement. In contrast, Expressed Client Concerns were more commonly reported by therapists with positive general attitudes towards EBPs, and among therapists delivering a parent training EBP. Limited Client Engagement but not Expressed Concerns were linked with therapists’ self-reported ability to carry out the EBP with the target client. Findings suggest that client engagement challenges are frequent during the delivery of EBPs, but may impact implementation differently based on whether they relate to challenges in engaging clients in therapy activities versus addressing concerns raised by clients
Retinal processing and opponent mechanisms mediating ultraviolet polarization sensitivity in rainbow trout (Oncorhynchus mykiss)

SUMMARY A number of teleost fishes have photoreceptor mechanisms to detect linearly polarized light. We studied the neuronal mechanism underlying this ability. It was found that a polarized signal could be detected in rainbow trout (Oncorhynchus mykiss) both in the electroretinogram (ERG) and in the compound action potential (CAP) measured in the optic nerve, indicating a strong retinal contribution to the processing of polarized light. The CAP recordings showed a W-shaped sensitivity curve, with a peak at 0°, 90° and 180°, consistent with processes for both vertical and horizontal orientation. By contrast, the ERG recordings reveal a more complex pattern. In addition to the peaks at 0°, 90° and 180°, two additional peaks appeared at 45° and 135°. This result suggests a specialized contribution of the outer retina in the processing of polarized light. The spectral sensitivity of the mechanisms responsible for these intermediate peaks was studied using chromatic adaptation. Here we show that long wavelength-sensitive (LWS) cone mechanism adaptation shifted the intermediate peaks towards 90°, whereas ultraviolet-sensitive (UVS) cone mechanism adaptation shifted the peaks away from 90° towards either 0° or 180°. These results provide further confirmation that the 90° peak is dominated by the LWS cone mechanism and the 0° and 180° peaks are dominated by the UVS cone mechanism. In addition, a pharmacological approach was used to examine the retinal neural mechanisms underlying polarization sensitivity. The effect of blocking negative feedback from horizontal cells to cones on the ERG was studied by making intraocular injections of low doses of cobalt, known to block this feedback pathway. It was found that the intermediate peaks seen in the ERG polarization sensitivity curves were eliminated after application of cobalt, suggesting that these peaks are due to outer retinal inhibition derived from feedback of horizontal cells onto cones. A simple computational model was developed to evaluate these results. The model consists of opponent and non-opponent processing elements for the two polarization detectors. This model provides a first approximation analysis suggesting that opponent processing occurs in the outer retina for polarization vision. Although it seems that polarization vision uses a slightly more complicated coding scheme than colour vision, the results presented in this paper suggest that opponent and non-opponent channels process polarization information.
Automatic role recognition in multiparty recordings using social networks and probabilistic sequential models

The automatic analysis of social interactions is attracting significant interest in the multimedia community. This work addresses one of the most important aspects of the problem, namely the recognition of roles in social exchanges. The proposed approach is based on Social Network Analysis, for the representation of individuals in terms of their interactions with others, and probabilistic sequential models, for the recognition of role sequences underlying the sequence of speakers in conversations. The experiments are performed over different kinds of data (around 90 hours of broadcast data and meetings), and show that the performance depends on how formal the roles are, i.e. on how much they constrain people behavior.
Measuring Hemoglobin Levels in the Optic Disc of Parkinson's Disease Patients Using New Colorimetric Analysis Software

Objective. To evaluate a new method of measuring hemoglobin (Hb) levels and quantifying the color changes in the optic nerve head of Parkinson's disease (PD) patients. We also compared differences in retinal nerve fiber layer (RNFL) thicknesses obtained using spectral domain optical coherence tomography (OCT) device between PD group and healthy group. Methods. One hundred and fifty-five PD patients and 91 sex- and age-matched healthy subjects were included in this cross-sectional study. OCT examinations and one photograph of the optic disc were performed. The Laguna ONhE (“optic nerve hemoglobin”; Insoft SL, Tenerife, Spain) software was used to analyze the Hb level on the acquired optic disc photographs. Results. PD patients exhibited significantly reduced mean optic disc Hb percentages (57.56% in PD, 67.63% in healthy subjects; P = 0.001) as well as reduced Hb in almost all analyzed sectors, with the largest differences detected in the inferior and nasal sectors. RNFL parameters were significantly reduced in PD patients compared with healthy subjects, especially in the inferior quadrant. Conclusions. Measurements of optic disc Hb levels obtained with the Laguna ONhE software had good ability to detect optic nerve color changes (more papillary paleness and consequently this could suggest optic atrophy and axonal loss) in PD patients.
Representation of Abstract Quantitative Rules Applied to Spatial and Numerical Magnitudes in Primate Prefrontal Cortex

Processing quantity information based on abstract principles is central to intelligent behavior. Neural correlates of quantitative rule selectivity have been identified previously in the prefrontal cortex (PFC). However, whether individual neurons represent rules applied to multiple magnitude types is unknown. We recorded from PFC neurons while monkeys switched between “greater than/less than” rules applied to spatial and numerical magnitudes. A majority of rule-selective neurons responded only to the quantitative rules applied to one specific magnitude type. However, another population of neurons generalized the magnitude principle and represented the quantitative rules related to both magnitudes. This indicates that the primate brain uses rule-selective neurons specialized in guiding decisions related to a specific magnitude type only, as well as generalizing neurons that respond abstractly to the overarching concept “magnitude rules. ”
Approximate False Positive Rate Control in Selection Frequency for Random Forest

Random Forest has become one of the most popular tools for feature selection. Its ability to deal with high-dimensional data makes this algorithm especially useful for studies in neuroimaging and bioinformatics. Despite its popularity and wide use, feature selection in Random Forest still lacks a crucial ingredient: false positive rate control. To date there is no efficient, principled and computationally light-weight solution to this shortcoming. As a result, researchers using Random Forest for feature selection have to resort to using heuristically set thresholds on feature rankings. This article builds an approximate probabilistic model for the feature selection process in random forest training, which allows us to compute an estimated false positive rate for a given threshold on selection frequency. Hence, it presents a principled way to determine thresholds for the selection of relevant features without any additional computational load. Experimental analysis with synthetic data demonstrates that the proposed approach can limit false positive rates on the order of the desired values and keep false negative rates low. Results show that this holds even in the presence of a complex correlation structure between features. Its good statistical properties and light-weight computational needs make this approach widely applicable to feature selection for a wide-range of applications.
Characterization of SiCN Ceramic Material Dielectric Properties at High Temperatures for Harsh Environment Sensing Applications

A novel method is presented in this paper to precisely characterize the dielectric properties of silicon carbon nitride (SiCN) ceramic materials at high temperatures for wireless passive sensing applications. This technique is based on a high quality factor (Q) dielectrically loaded cavity resonator, which allows for accurate characterization of both dielectric constant and loss tangent. The dielectric properties of SiCN ceramics are characterized from 25 °C to 1000 °C. Two different metallization processes are implemented for the measurements with the highest temperatures of 500 °C and 1000 °C, respectively. A custom-made thru-reflect-line calibration kit is used to maximize the measurement accuracy at every temperature point. It is observed that the dielectric constant and loss tangent of the SiCN sample without Boron doping increase from 3.707 to 3.883 and from 0.0038 to 0.0213, respectively, when the temperature is raised from 25 °C to 500 °C, and for the SiCN with Boron doping (SiBCN), the dielectric constant and loss tangent increase from 4.817 to 5.132 and from 0.0020 to 0.0186, respectively, corresponding to the temperature ranging from 25 °C to 1000 °C. Experimental uncertainties for extracted εr and tanδ are no more than 0.0004 and 0.0001, respectively. The temperature dependency of Si(B)CN dielectric properties, as well as the dielectrically loaded cavity resonator structure, provides the basis for the development of wireless passive temperature sensors for high-temperature applications.
Message framing and counseling of parents on children’s physical activity – an experimental study

ABSTRACT How messages are framed (gain or loss frame) modulate the effect of health information on physical activity level in adults. The role of framing of health information messages to parents about their child's physical activity is unknown. Adult participants (parents) were randomized to see a video that either emphasized the benefits of physical activity (gain frame) or the risks of physical inactivity (loss frame) in children. The primary outcome was the change in the reported level of physical activity for their children between baseline and two-week follow-up. 92 individuals participated in the study and we obtained follow-up data for 48 participants (20 gain frame and 28 loss frame). Using a generalized linear model, we found that the frame presented to parents significantly influenced the trajectory of their child’s physical activity (p = 0.03), with the loss frame condition resulting in more favorable trajectory. Both the willingness to pay for organized physical activities and the perceived barriers to physical activity were similar between the two intervention groups. The change in the reported level of activity of the child over a two-week period was significantly different whether parents were exposed to a loss frame or a gain frame video message.
Galactose Oxidase from Fusarium oxysporum - Expression in E. coli and P. pastoris and Biochemical Characterization

A gene coding for galactose 6-oxidase from Fusarium oxysporum G12 was cloned together with its native preprosequence and a C-terminal His-tag, and successfully expressed both in Escherichia coli and Pichia pastoris. The enzyme was subsequently purified and characterized. Among all tested substrates, the highest catalytic efficiency (k cat/Km) was found with 1-methyl-β-D-galactopyranoside (2.2 mM−1 s−1). The Michaelis constant (Km) for D-galactose was determined to be 47 mM. Optimal pH and temperature for the enzyme activity were 7.0 and 40°C, respectively, and the enzyme was thermoinactivated at temperatures above 50°C. GalOx contains a unique metalloradical complex consisting of a copper atom and a tyrosine residue covalently attached to the sulphur of a cysteine. The correct formation of this thioether bond during the heterologous expression in E. coli and P. pastoris could be unequivocally confirmed by MALDI mass spectrometry, which offers a convenient alternative to prove this Tyr-Cys crosslink, which is essential for the catalytic activity of GalOx.