Miracle-dz/UniFAR-FTUs huggingface dataset:
Predictive utility of apolipoprotein E genotype for Alzheimer disease in outpatients with mild cognitive impairment.

BACKGROUND In cognitively impaired patients without dementia, the utility of apolipoprotein E (APOE) genotyping is unclear. OBJECTIVE To evaluate the predictive utility of the APOE epsilon4 genotype for conversion to probable Alzheimer disease (AD). DESIGN Naturalistic, longitudinal study. SETTING Memory disorders outpatient clinic. PATIENTS A total of 136 patients with memory complaints were determined to have mild cognitive impairment and were evaluated every 6 months. Fifty-seven age- and sex-matched healthy controls were evaluated annually. MAIN OUTCOME MEASURES Primary outcome measures included conversion to AD. Secondary outcome measures included change over time in Mini-Mental State Examination (MMSE) score and Selective Reminding Test (SRT) delayed recall score. RESULTS The APOE epsilon4 allele was present in 25% of patients and 21% of healthy controls. During a mean +/- SD follow-up of 35.2 +/- 24.3 months, 35 of 136 patients converted to AD. APOE epsilon4 carrier status did not differ between converters (31%) and nonconverters to AD (23%, P = .3) and did not affect the time trend in MMSE or SRT scores in the entire sample. Four of 5 APOE epsilon4 homozygotes converted to AD compared with 7 of 29 heterozygotes (P = .02). In a Cox proportional hazards model stratified by age quartiles, after controlling for sex, education, MMSE score, and SRT delayed recall score, APOE epsilon4 increased the risk of AD in patients 70 to 85 years old (n = 57; risk ratio, 2.77; 95% confidence interval, 1.1-7.3; P = .03) but not in patients 55 to 69 years old (n = 79; P = .7). CONCLUSIONS APOE epsilon4 carrier status was associated with conversion to AD in older outpatients after controlling for known demographic and clinical risk factors, and APOE epsilon4 homozygosity was associated with increased risk of conversion to AD. However, APOE epsilon4 carrier status by itself did not predict cognitive decline or conversion to AD, indicating that APOE genotyping in patients with mild cognitive impairment may have limited clinical applicability for prediction of outcome.
Trust in political institutions over the business cycle in Spain

The Great Recession has implied a strong increase of the unemployment rate in Spain that surpassed 25% in 2012, the highest rate in western economies. At the same time, trust in political institutions has greatly deteriorated. The goal of this research is to study how trust in political institutions has moved along the business cycle in Spain over the last twenty years by using a battery of standard statistical methods. Moreover, this study also investigates the existence of a long-run relationship applying the autoregressive distributed lag (ADRL) bounds testing approach to cointegration. Once the existence of a longrun relationship is evidenced, we construct a model that allows us to quantitatively evaluate the impact of the business cycle on Spanish political trust. The empirical findings reveal that the unemployment rate has had a significant lagged impact on trust in political institutions.
Phase Space Formulation of Population Dynamics in Ecology

A phase space theory for population dynamics in Ecology is presented. This theory applies for a certain class of dynamical systems, that will be called M-systems, for which a conserved quantity, the M-function, can be defined in phase space. This M-function is the generator of time displacements and contains all the dynamical information of the system. In this sense the M-function plays the role of the hamiltonian function for mechanical systems. In analogy with Hamilton theory we derive equations of motion as derivatives over the resource function in phase space. A M-bracket is defined which allows one to perform a geometrical approach in analogy to Poisson bracket of hamiltonian systems. We show that the equations of motion can be derived from a variational principle over a functional J of the trajectories. This functional plays for M-systems the same role than the action S for hamiltonian systems. Finally, three important systems in population dynamics, namely, Lotka-Volterra, self-feeding and logistic evolution, are shown to be M-systems.
Promise and Paradox

We used self-report surveys to gather information on a broad set of non-cognitive skills from 1,368 eighth graders. At the student level, scales measuring conscientiousness, self-control, grit, and growth mindset are positively correlated with attendance, behavior, and test-score gains between fourth grade and eighth grade. Conscientiousness, self-control, and grit are unrelated to test-score gains at the school level, however, and students attending over-subscribed charter schools score lower on these scales than do students attending district schools. Exploiting admissions lotteries, we find positive impacts of charter school attendance on achievement and attendance but negative impacts on these non-cognitive skills. We provide suggestive evidence that these paradoxical results are driven by reference bias or the tendency for survey responses to be influenced by social context.
Combining morphological analysis and Bayesian Networks for strategic decision support

Morphological analysis (MA) and Bayesian networks (BN) are two closely related modelling methods, each of which has its advantages and disadvantages for strategic decision support modelling. MA is a method for defining, linking and evaluating problem spaces. BNs are graphical models which consist of a qualitative and quantitative part. The qualitative part is a cause-and-effect, or causal graph. The quantitative part depicts the strength of the causal relationships between variables. Combining MA and BN, as two phases in a modelling process, allows us to gain the benefits of both of these methods. The strength of MA lies in defining, linking and internally evaluating the parameters of problem spaces and BN modelling allows for the definition and quantification of causal relationships between variables. Short summaries of MA and BN are provided in this paper, followed by discussions how these two computer aided methods may be combined to better facilitate modelling procedures. A simple example is presented, concerning a recent application in the field of environmental decision support.
Linking radio to infrared: a radio source count model

We investigate the populations and evolution of normal and active galaxies by extending the recent infrared source count model of Rowan-Robinson into the radio. The far-infrared-radio correlation is used to extend the spectral energy distributions to the radio region, and it is assumed that there are two distinct populations of quasar: radio-loud and radio-quiet. It is found that the radio luminosity function and source count data are best fitted when the fraction of quasars that are radio-loud is allowed to increase with optical luminosity. The implications for this are discussed, as are the possible causes for the variation in radio-loud fraction.
Comparative analysis of three phase AC-DC controlled multi pulse converter

This paper addresses the comparative study of three phase controlled multi pulse converters used to drive the biomass, gas turbine, hydro, diesel and wind system based power plant which are the viable sources of renewable energy having different nature in respect of speed and voltage This paper approaches the input current shaping of controlled rectifier using multipulse current shaping concept. The developed mathematical model of multi pulse converters emulates the behavior of various multi pulse current shaping methods. The mathematical model is capable of replicating the operating behavior for converters with any number of rectifiers; 6-, 12-, 18-, 24-, 36-, and 48-pulse thyristor converters. The comparative study given in this paper covers cases on controlled rectifiers. As part of the simulated results on converter performance, data related to the Total Harmonic Distortion (THD), ripple in the output voltage, and power efficiency is given.
Negotiating the neurochemical self: anti-depressant consumption in women's recovery from depression

Anti-depressant treatment can be viewed as an exercise of biopower that is articulated through policies and practices aimed at the reduction of depression, population healthcare costs and effects on labour force productivity. Drawing upon a feminist governmentality perspective, this article examines the discourses that shaped women's experiences of anti-depressant medication in an Australian qualitative study on recovery from depression. The majority of women had been prescribed anti-depressants to treat a chemical imbalance in the brain, manage symptoms and restore normal functioning. One-third of participants identified anti-depressants as helpful in their recovery, while two-thirds were either highly ambivalent about, or critical of, medication as a solution to depression. Thirty-one women who identified the `positive' benefits of anti-depressants actively constituted themselves as biomedical consumers seeking to redress a chemical imbalance. The problem of depression, the emergence of molecular science and the push for pharmacological solutions are contributing to the discursive formation of new subject positions — such as the neurochemically deficient self. Three themes were identified in relation to medication use, namely restoring normality, signifying recovery success and control/uncertainty. Anti-depressant medication offered women a normalized pathway to successful recovery that stood in stark contrast to the biologically deficient and morally failing self. These women's stories importantly reveal the gender relations and paradoxes arising from biopolitical technologies that shape selfhood for women in advanced liberal societies.
Habitat-specific foraging strategies in Australasian gannets

ABSTRACT Knowledge of top predator foraging adaptability is imperative for predicting their biological response to environmental variability. While seabirds have developed highly specialised techniques to locate prey, little is known about intraspecific variation in foraging strategies with many studies deriving information from uniform oceanic environments. Australasian gannets (Morus serrator) typically forage in continental shelf regions on small schooling prey. The present study used GPS and video data loggers to compare habitat-specific foraging strategies at two sites of contrasting oceanographic regimes (deep water near the continental shelf edge, n=23; shallow inshore embayment, n=26), in south-eastern Australia. Individuals from the continental shelf site exhibited pelagic foraging behaviours typical of gannet species, using local enhancement to locate and feed on small schooling fish; in contrast only 50% of the individuals from the inshore site foraged offshore, displaying the typical pelagic foraging strategy. The remainder adopted a strategy of searching sand banks in shallow inshore waters in the absence of conspecifics and other predators for large, single prey items. Furthermore, of the individuals foraging inshore, 93% were male, indicating that the inshore strategy may be sex-specific. Large inter-colony differences in Australasian gannets suggest strong plasticity in foraging behaviours, essential for adapting to environmental change. Summary: Australasian gannets from two colonies in south-eastern Australia were equipped with GPS and miniature video data loggers to record foraging location and the prey preference.
Evaluation of methods for the prediction of membrane spanning regions

MOTIVATION A variety of tools are available to predict the topology of transmembrane proteins. To date no independent evaluation of the performance of these tools has been published. A better understanding of the strengths and weaknesses of the different tools would guide both the biologist and the bioinformatician to make better predictions of membrane protein topology. RESULTS Here we present an evaluation of the performance of the currently best known and most widely used methods for the prediction of transmembrane regions in proteins. Our results show that TMHMM is currently the best performing transmembrane prediction program.
Comparison of cognitive flexibility and planning ability in patients with obsessive compulsive disorder, patients with obsessive compulsive personality disorder, and healthy controls

Background Cognitive functioning in individuals with Obsessive Compulsive Disorder (OCD) and with Obsessive Compulsive Personality Disorder (OCPD) has not been adequately studied. Aim Examine the cognitive flexibility and planning ability of individuals with OCD and OCPD. Methods Twenty patients with OCD and 25 patients with OCPD who had not taken medication in the previous two weeks were identified in an outpatient psychology clinic in Tehran, and 25 healthy control subjects were identified from the university staff and local community residents. All participants were administered the 28-item version of the General Health Questionnaire (GHQ-28), the Wisconsin Card Sorting Test (WCST), and the Tower of London (TOL) test. Two measures of the WCTS (number of perseverative errors and number of categories completed) were used to assess cognitive flexibility and three measures of the TOL (total number of moves in 12 trials, total response time, and planning time) were used to assess planning ability. Results The level of current psychological distress in the two patient groups was significantly greater than that in the control group. After adjusting for demographic variables and the level of psychological distress, both OCD patients and OCPD patients made more perseverative errors on the WCST than control subjects, and the OCD patients (but not the OCPD patients) completed significantly fewer categories than the control subjects. Both the OCD patients and OCPD patients required significantly more moves than control subjects to complete the 12 TOL tasks and OCD patients took significantly longer than both OCPD patients and control subjects to complete the tasks. Conclusions Individuals with OCD and OCPD have impaired cognitive flexibility and planning ability compared to healthy controls, and there are some differences in these measures of cognitive functioning between OCD and OCPD. Long term follow-up studies of OCD and OCPD that assess changes in cognitive measures as the severity of obsessive compulsive symptoms wax and wane will be needed to determine whether or not such cognitive measures have diagnostic or clinical relevance for obsessive compulsive disorders.
Achieving high availability in wireless networks by an optimal number of Rayleigh-fading links

Future cellular networks have to meet enormous, unprecedented, and multifaceted requirements, such as high availability and low latency, in order to provide service to new applications in, e.g., vehicular communication, smart grids, and industrial automation. Such applications often demand a temporal availability of six nines or higher. In this work, we investigate how high availability can be achieved in wireless networks. To elaborate, we focus on the joint availability of power-controlled Rayleigh-fading links while using selection combining. By applying a basic availability model for uncorrelated links, we determine whether it is more efficient in terms of power to utilize multiple links in parallel rather than boosting the power of a stand-alone link. The results reveal that, for high availability, it can actually be beneficial to use multiple links in parallel. For instance, an availability of 1-1012 is achieved with 100 dB less power when power is shared among multiple links. Depending upon the availability desired, an optimal number of parallel links in terms of power consumption exists. Additionally, we extend the availability model to correlated links and investigate the performance degradation due to correlation.
Orthographic/Phonological Facilitation of Naming Responses in the Picture–Word Task: An Event-Related fMRI Study Using Overt Vocal Responding

In the picture-word interference task, naming responses are facilitated when a distractor word is orthographically and phonologically related to the depicted object as compared to an unrelated word. We used event-related functional magnetic resonance imaging (fMRI) to investigate the cerebral hemodynamic responses associated with this priming effect. Serial (or independent-stage) and interactive models of word production that explicitly account for picture-word interference effects assume that the locus of the effect is at the level of retrieving phonological codes, a role attributed recently to the left posterior superior temporal cortex (Wernicke's area). This assumption was tested by randomly presenting participants with trials from orthographically related and unrelated distractor conditions and acquiring image volumes coincident with the estimated peak hemodynamic response for each trial. Overt naming responses occurred in the absence of scanner noise, allowing reaction time data to be recorded. Analysis of this data confirmed the priming effect. Analysis of the fMRI data revealed blood oxygen level-dependent signal decreases in Wernicke's area and the right anterior temporal cortex, whereas signal increases were observed in the anterior cingulate, the right orbitomedial prefrontal, somatosensory, and inferior parietal cortices, and the occipital lobe. The results are interpreted as supporting the locus for the facilitation effect as assumed by both classes of theoretical model of word production. In addition, our results raise the possibilities that, counterintuitively, picture-word interference might be increased by the presentation of orthographically related distractors, due to competition introduced by activation of phonologically related word forms, and that this competition requires inhibitory processes to be resolved. The priming effect is therefore viewed as being sufficient to offset the increased interference. We conclude that information from functional imaging studies might be useful for constraining theoretical models of word production.
Accelerating Self-Motion Displays Produce More Compelling Vection in Depth

We examined the vection in depth induced when simulated random self-accelerations (jitter) and periodic self-accelerations (oscillation) were added to radial expanding optic flow (simulating constant-velocity forward self-motion). Contrary to the predictions of sensory-conflict theory frontal-plane jitter and oscillation were both found to significantly decrease the onsets and increase the speeds of vection in depth. Depth jitter and oscillation had lesser, but still significant, effects on the speed of vection in depth. A control experiment demonstrated that adding global perspective motion which simulated a constant-velocity frontal-plane self-motion had no significant effect on vection in depth induced by the radial component of the optic flow. These results are incompatible with the notion that constant-velocity displays produce optimal vection. Rather, they indicate that displays simulating self-acceleration can often produce more compelling experiences of self-motion in depth.
A note on the equilibrium existence problem in discontinuous games

In this note, we prove an equilibrium existence theorem for games with discontinuous payoffs and convex and compact strategy spaces. It generalizes the classical result of Reny (1999), as well as the recent paper of McLennan, Monteiro, and Tourky (2011). Our conditions are simple and easy to verify. Importantly, examples of spatial location models show that our conditions allow for economically meaningful payoff discontinuities, that are not covered by other conditions in the literature.
New Insights into the PPARγ Agonists for the Treatment of Diabetic Nephropathy

Diabetic nephropathy (DN) is a severe complication of diabetes and serves as the leading cause of chronic renal failure. In the past decades, angiotensin-converting enzyme inhibitors (ACEIs)/angiotensin II receptor blockers (ARBs) based first-line therapy can slow but cannot stop the progression of DN, which urgently requests the innovation of therapeutic strategies. Thiazolidinediones (TZDs), the synthetic exogenous ligands of nuclear receptor peroxisome proliferator-activated receptor-γ (PPARγ), had been thought to be a promising candidate for strengthening the therapy of DN. However, the severe adverse effects including fluid retention, cardiovascular complications, and bone loss greatly limited their use in clinic. Recently, numerous novel PPARγ agonists involving the endogenous PPARγ ligands and selective PPARγ modulators (SPPARMs) are emerging as the promising candidates of the next generation of antidiabetic drugs instead of TZDs. Due to the higher selectivity of these novel PPARγ agonists on the regulation of the antidiabetes-associated genes than that of the side effect-associated genes, they present fewer adverse effects than TZDs. The present review was undertaken to address the advancements and the therapeutic potential of these newly developed PPARγ agonists in dealing with diabetic kidney disease. At the same time, the new insights into the therapeutic strategies of DN based on the PPARγ agonists were fully addressed.
Investigation of Endoglin Wild-Type and Missense Mutant Protein Heterodimerisation Using Fluorescence Microscopy Based IF, BiFC and FRET Analyses

The homodimeric transmembrane receptor endoglin (CD105) plays an important role in angiogenesis. This is highlighted by mutations in its gene, causing the vascular disorder HHT1. The main role of endoglin function has been assigned to the modulation of transforming growth factor β and bone morphogenetic protein signalling in endothelial cells. Nevertheless, other functions of endoglin have been revealed to be involved in different cellular functions and in other cell types than endothelial cells. Compared to the exploration of its natural function, little experimental data have been gathered about the mode of action of endoglin HHT mutations at the cellular level, especially missense mutations, and to what degree these might interfere with normal endoglin function. In this paper, we have used fluorescence-based microscopic techniques, such as bimolecular fluorescence complementation (BiFC), immunofluorescence staining with the endoglin specific monoclonal antibody SN6, and protein interaction studies by Förster Resonance Energy Transfer (FRET) to investigate the formation and cellular localisation of possible homo- and heterodimers composed of endoglin wild-type and endoglin missense mutant proteins. The results show that all of the investigated missense mutants dimerise with themselves, as well as with wild-type endoglin, and localise, depending on the position of the affected amino acid, either in the rough endoplasmic reticulum (rER) or in the plasma membrane of the cells. We show that the rER retained mutants reduce the amount of endogenous wild-type endoglin on the plasma membrane through interception in the rER when transiently or stably expressed in HMEC-1 endothelial cells. As a result of this, endoglin modulated TGF-β1 signal transduction is also abrogated, which is not due to TGF-β receptor ER trafficking interference. Protein interaction analyses by FRET show that rER located endoglin missense mutants do not perturb protein processing of other membrane receptors, such as TβRII, ALK5 or ALK1.