Miracle-dz/UniFAR-FTUs huggingface dataset:
Transcriptome Analysis of Adult C. elegans Cells Reveals Tissue-specific Gene and Isoform Expression

The biology and behavior of adults differ substantially from those of developing animals, and cell-specific information is critical for deciphering the biology of multicellular animals. Thus, adult tissue-specific transcriptomic data are critical for understanding molecular mechanisms that control their phenotypes. We used adult cell-specific isolation to identify the transcriptomes of C. elegans’ four major tissues (or “tissue-ome”), identifying ubiquitously expressed and tissue-specific “super-enriched” genes. These data newly reveal the hypodermis’ metabolic character, suggest potential worm-human tissue orthologies, and identify tissue-specific changes in the Insulin/IGF-1 signaling pathway. Tissue-specific alternative splicing analysis identified a large set of collagen isoforms and a neuron-specific CREB isoform. Finally, we developed a machine learning-based prediction tool for 70 sub-tissue cell types, which we used to predict cellular expression differences in IIS/FOXO signaling, stage-specific TGF-b activity, and basal vs. memory-induced CREB transcription. Together, these data provide a rich resource for understanding the biology governing multicellular adult animals
Comments on Nonfinite Adverbial Patterns in English Prose Fiction: A Simple Model for Analysis and Use

This study aims to present an accessible model of some frequent nonfinite adverbial types occurring in English prose fiction. As its main syntactic argument, it recognizes that these adverbials are mostly elliptical in that there are some dependent-clause markers one can assume to be implicit when supplying those elements back into the clause complex. Some comments are provided at the end on the interfaces existing between these adverbials and other systems and forces in language. These marry up with linguistic and discursive concepts like rank-shifting, necessary indeterminacy, and ambiguity as an integral part of literary semiosis, figures of speech, stylistic parallelism, cohesion, and so on. This study affords better and deeper insights into the nature of the clause and the creative verbal play brought off in natural situations of use. It also has implications for advanced students and teachers of English, program/syllabus designers and evaluators, linguists, and applied linguists.
Skull structure and evolution in tyrannosaurid dinosaurs

Tyrannosauridae can be subdivided into two distinct subfamilies—the Albertosaurinae and the Tyrannosaurinae. Previ− ously recognized subdivisions Aublysodontinae and Shanshanosaurinae are rejected because they are based on insuffi− cient material and juvenile specimens. Our results are based upon a phylogenetic analysis using PAUP program (Swofford 1999) of 77 skull characters and seven genera (Albertosaurus, Alioramus, Daspletosaurus, Gorgosaurus, Nanotyrannus, Tarbosaurus, and Tyrannosaurus); with Allosaurus as outgroup. Of the 77 characters used, more than half were parsimony informative. A single most parsimonious tree was obtained with the Tree Length being 88. The analysis of cranial characters and comparison of postcranial features reveal that Tarbosaurus bataar is not the sister taxon of Tyrannosaurus rex (contra Holtz 2001). Their similarities are partially due to the fact that both are extremely large ani− mals. Thus, Tarbosaurus should be considered a genus distinct from Tyrannosaurus.
Vegetable, fruit and nitrate intake in relation to the risk of Barrett's oesophagus in a large Dutch cohort

There are few epidemiological data on the dietary risk factors of Barrett's oesophagus, a precursor of oesophageal adenocarcinoma. The present study investigated the association between vegetable, fruit and nitrate intake and Barrett's oesophagus risk in a large prospective cohort. The Netherlands Cohort Study recruited 120 852 individuals aged 55–69 years in 1986. Vegetable and fruit intake was assessed using a 150-item FFQ, and nitrate intake from dietary sources and drinking water was determined. After 16·3 years of follow-up, 433 cases (241 men and 192 women) of Barrett's oesophagus with specialised intestinal metaplasia and 3717 subcohort members were analysed in a case–cohort design using Cox proportional hazards models while adjusting for potential confounders. Men exhibited a lower risk of Barrett's oesophagus in the highest v. the lowest quintile of total (multivariable-adjusted hazard ratio (HR): 0·66, 95 % CI 0·43, 1·01), raw (HR 0·63, 95 % CI 0·40, 0·99), raw leafy (HR 0·55, 95 % CI 0·36, 0·86) and Brassica (HR 0·64, 95 % CI 0·41, 1·00) vegetable intake. No association was found for other vegetable groups and fruits. No significant associations were found between vegetable and fruit intake and Barrett's oesophagus risk among women. Total nitrate intake was inversely associated with Barrett's disease risk in men (HR 0·50, 95 % CI 0·25, 0·99) and positively associated with it in women (HR 3·77, 95 % CI 1·68, 8·45) (P for interaction = 0·04). These results suggest that vegetable intake may contribute to the prevention of Barrett's oesophagus. The possible differential effect in men and women should be evaluated further.
Librarian-Faculty Partnerships in Instruction

Alors que les bibliothecaires de l'enseignement superieur se considerent comme des acteurs importants dans la societe savante, les enseignants n'ont pas le meme regard a leur egard et les etudiants pensent pouvoir se debrouiller seuls, certains meme ne connaissant pas le systeme d'information. Une instruction integree pour les etudiants, une instruction pour le personnel enseignant et un soutien administratif pour l'instruction bibliographique permettraient une meilleure consideration des bibliothecaires
Getting to the Right Place at the Right Time: Another Piece of the STEMI Puzzle.

Primary percutaneous coronary intervention (PCI) is the preferred revascularization strategy for patients presenting with ST-segment–elevation myocardial infarction (STEMI). 1 The association between timely performance of primary PCI and reduced mortality has been well established in several observational studies.2,3 These and other studies have resulted in a series of performance metrics, including door-to-balloon (D2B) time, first medical contact (FMC)-to-device time, and door-in-door-out time (for patients presenting to non–PCI-capable hospitals), which constitute goals for best medical practice. Current guidelines recommend FMC-to-device time of ≤90 minutes for patients presenting to PCI-capable hospitals and ≤120 minutes for patients presenting to non–PCI-capable hospitals.1 Despite substantial efforts during the past 2 decades to develop systems of care for the treatment of STEMI as well as to promote these recommendations, a significant percentage of patients (>30%) do not receive reperfusion therapy within guideline-recommended timeframes.4,5 See Article by Green et al Several barriers to timely treatment of patients with STEMI exist across the continuum of care. The recognition of symptoms by patients is often the largest delay in revascularization.6 In addition, the availability and delivery of emergency medical services (EMS) nationwide is heterogeneous and dependent on local resources. Although use of EMS transport is associated with reductions in ischemic time and treatment delays, previous data have shown that only ≈60% of patients with STEMI nationwide use EMS for transport to the hospital.7 The recognition of ST-segment elevation by prehospital ECG can be another barrier to timely care and has been the target of programs to improve early identification of patients with STEMI. Such prehospital diagnosis of STEMI can also be challenging because symptoms can at times be vague and nonspecific, and only a minority of patients presenting with chest pain are actually experiencing an STEMI. Even if symptoms are …
Analyzing Group Level Effects with Clustered Data Using Taylor Series Linearization.

Clustered data (e.g., students within schools) are often analyzed in educational research where data are naturally nested. As a consequence, multilevel modeling (MLM) has commonly been used to study the contextual or group-level (e.g., school) effects on individual outcomes. The current study investigates the use of an alternative procedure to MLM: regression using Taylor series linearization (TSL) variance estimation. Despite the name, regressions using TSL are straightforward to conduct, can yield consistent and unbiased estimates and standard errors (given the appropriate conditions), and can be performed using a variety of commerciallyand freely-available statistical software. I analyze a subsample of the High School and Beyond (HSB) dataset using MLM, regression using TSL, and ordinary least squares regression and compare results. In addition, 12,000 random samples are drawn from the HSB dataset of varying level-one and level-two sample sizes in order to compute biases in standard errors based on the different conditions. Sample R and SAS syntax showing how to run regressions using TSL are provided.
Towards Comprehensive User Modeling on the Social Web for Personalized Link Recommendations

User modeling for individual users on the Social Web plays a significant role and is a fundamental step for personalization as well as recommendations. Previous studies have proposed various user modeling strategies in different dimensions such as (1) interest representation, (2) interest propagation, (3) content enrichment and (4) temporal dynamics of user interests. This research mainly focuses on the first two dimensions interest representation and propagation. In addition, we also investigate the combination of these four dimensions and their synergistic effect on the quality of user modeling. Different user modeling strategies will then be evaluated in the context of personalized link recommender systems using standard evaluation methodologies such as Mean Reciprocal Rank (MRR), recall (R@N) and success (S@N) at rank N.
Flow measurement using micro-PIV and related temperature distributions within evaporating sessile drops of self-rewetting mixtures of 1-pentanol and water

Recently interest has arisen in the use of so-call ed self-rewetting mixtures for micro-scale heat transfer systems. Such fluids, in which the surface tension can increase with increasing temperature, are expected to offer superior evaporative cooling perf ormance by extending the region of operation before dryout of the heated surface sets in. Whilst improved p rformance has been shown in some practical situat ions using these fluids, it is not entirely clear as to the mechanism of such improvements. We have studied the flow within evaporating sessile drops of 1-pentanol-water mixtures using micro-PIV and have observed three stages in the evaporation p rocess. During the first stage there appears to be a single toroidal vortex with flow inwards along the base of the drop. The vortex only occupies the central reg ion of the drop and appears to pulsate, reducing in size d uring evaporation. This is followed by a second tra nsition stage to a third stage in which the flow is directe d radially outward, as observed by us for pure wate r droplet evaporation and in the latter stages of ethanol/wat er drop evaporation. Temperature measurements, usin g IR thermography suggest that the initial stage of evap oration may be controlled by thermal Marangoni effe cts as opposed to the concentration driven Marangoni flows po tulated for ethanol-water mixtures.
Distinct Oral Neutrophil Subsets Define Health and Disease States

Neutrophils exit the vasculature and swarm to sites of inflammation and infection. Neutrophils are also actively recruited to the healthy periodontium without eliciting clinical signs of inflammation, suggesting a unique immune surveillance neutrophil function. We hypothesized that oral neutrophils in the healthy periodontium exist in a “para-inflammatory” state that allows neutrophils to symbiotically interact with the commensal oral microflora. Using the principles of immunophenotyping, we identified four distinct neutrophil subsets: resting circulatory neutrophils, two para-inflammatory and one pro-inflammatory tissue neutrophil phenotypes in the absence and presence of chronic inflammation, respectively. This work is the first to comprehensively characterize healthy oral neutrophils and identity the para-inflammatory neutrophil phenotype, thereby demonstrating that not all neutrophils trafficking through periodontium are fully activated. In addition to establishing possible diagnostic and treatment monitoring biomarkers, the oral tissue neutrophil phenotype model builds on existing literature suggesting that the healthy periodontium may be in a para-inflammatory state.
The Neurological Presentation of Ceruloplasmin Gene Mutations

Aceruloplasminemia is an autosomal recessive disorder of iron metabolism resulting from mutations of the ceruloplasmin gene. To better define the neurological phenotype of aceruloplasminemia we reviewed reports of published cases and sought details of unpublished ones. We identified 32 published reports and 1 unpublished case. The age at diagnosis ranged from 16 to 71 years with a mean of 51. For the 28 homozygous cases the most common presentation was with cognitive impairment (12/28, 42%) accompanied by craniofacial dyskinesia (8/28, 28%), cerebellar ataxia (13/28, 46%) and retinal degeneration (21/28, 75%). Four heterozygotes presented with cerebellar signs or tremor, whilst 1 had chorea-athetosis. There were no genotype-phenotype associations, but homozygotes tended to have severer disease.
Learning in the Oil Futures Markets: Evidence and Macroeconomic Implications

Abstract Using oil futures, we examine expectation formation and how it alters the macroeconomic transmission of shocks. Our empirical framework, where investors learn about the persistence of oil-price movements, successfully replicates the fluctuations in oil-price futures since the Late 1990s. By embedding this learning mechanism in an estimated model, we document that an increase in the persistence of TFP-driven fluctuations in oil demand largely accounts for investors' perceptions that oil-price movements became increasingly permanent during the 2000s. Learning alters the macroeconomic impact of shocks, making the responses time dependent and conditional on perceptions of shocks' likely persistence.
Infrared and visible image fusion using Latent Low-Rank Representation

Infrared and visible image fusion is an important problem in the field of image fusion which has been applied widely in many fields. To better preserve the useful information from source images, in this paper, we propose a novel image fusion method based on latent low-rank representation(LatLRR) which is simple and effective. Firstly, the source images are decomposed into low-rank parts(global structure) and saliency parts(local structure) by LatLRR. Then, the lowrank parts are fused by weighted-average strategy to preserve more contour information. Then, the saliency parts are simply fused by sum strategy which is a efficient operation in this fusion framework. Finally, the fused image is obtained by combining the fused low-rank part and the fused saliency part. Compared with other fusion methods experimentally, the proposed method has better fusion performance than stateof-the-art fusion methods in both subjective and objective evaluation. The Code of our fusion method is available at this https URL Infrared visible latlrr
The Effect of Peer Tutoring in Physical Education for Middle School Students with Severe Disabilities

This study assessed the effect of peer tutoring on physical, instructional and social interaction behaviors between middle school age students with severe and multiple disabilities (SMD) and peers without disabilities. Additional measures addressed the activity time of students with SMD. The study was conducted in inclusive general physical education settings under two instructional support conditions for students with SMD: (a) teacher-directed, and (b) peer-mediated. During teacher-directed conditions students with SMD had frequent interactions with education personnel while interactions with peers were minimal. When peer –mediated conditions were implemented, the interactions between target students and trained peer tutors increased, however, data did not present stability and clear trend. The trained peer tutors delivered fewer instructions during intervention than teachers during baseline. The activity engagement time did not change across the two conditions for both students with SMD. The social interactions remained low throughout the study.
The effects of happy and angry expressions on identity and expression memory for unfamiliar faces

We investigated the influence of happy and angry expressions on memory for new faces. Participants were presented with happy and angry faces in an intentional or incidental learning condition and were later asked to recognise the same faces displaying a neutral expression. They also had to remember what the initial expressions of the faces had been. Remember/know/guess judgements were made both for identity and expression memory. Results showed that faces were better recognised when presented with a happy rather than an angry expression, but only when learning was intentional. This was mainly due to an increase of the "remember" responses for happy faces when encoding was intentional rather than incidental. In contrast, memory for emotional expressions was not different for happy and angry faces whatever the encoding conditions. We interpret these findings according to the social meaning of emotional expressions for the self.
FAST TRACK PAPER: Inference of mantle viscosity from GRACE and relative sea level data

A biomass management system using sunlight during the daytime for purifying water having impurities. The biomass management system of the present invention is adapted for use in an impoundment holding water which has an inlet for delivering impure water into the impoundment and an outlet for delivering purified water out of the impoundment. A first type of rooted bottom dwelling plant grows on the bottom of the impoundment and removes some of the impurities in the water. A plurality of elongated channels float on the surface of the water in the impoundment above the bottom dwelling plants. Each of the plurality of the elongated channels are secured in the impoundment in a substantially North-South orientation. Each of the plurality of elongate channels have a holding region with inwardly shaped sides. A second type of floating rootless plant grows in the holding region on the surface of the water in each of the channels and removes some of the impurities in the water. The North-South orientation of the elongated channels and their inwardly shaped sides of the channels allow sunlight to be delivered to all of the bottom dwelling plants.
Effects of Fengliao-Changweikang in Diarrhea-predominant Irritable Bowel Syndrome Rats and Its Mechanism Involving Colonic Motility

Background/Aims This study was designed to investigate the effect of Fengliao-Changweikang (FLCWK) in diarrhea-predominant irritable bowel syndrome (IBS-D) rats and explore its underlying mechanisms. Methods IBS-D model rats were induced by neonatal maternal separation (NMS) combined with restraint stress (RS). In in vivo experiments, the model rats were randomly divided into 5 groups: NMS + RS, FLCWK (low dose, middle dose, and high dose), and pinaverium bromide. The normal control (no handling) rats were classified as the NH group. The therapeutic effect of FLCWK was evaluated by fecal characteristics, electromyographic response and abdominal withdrawal reflex scores. In in vitro experiments, the model rats were randomly divided into 2 groups: NMS + RS, FLCWK (middle dose), and no handling rats were used as the NH group. The differences in basic tension and ACh-induced tension of isolated colonic longitudinal smooth muscle strips (CLSMs) among the 3 groups were observed. In addition, different inhibitors (nifedipine, TMB-8, L-NAME, methylene blue, and 4-AP) were pretreated to explore the underlying mechanisms. Results In in vivo experiments, fecal characteristics, electromyographic response, and abdominal withdrawal reflex scores significantly improved in the FLCWK group, compared with the NMS + RS group. In in vitro experiments, the basic tension and ACh-induced tension of CLSMs in IBS-D rats were significantly inhibited by FLCWK. After pre-treatment with different inhibitors, the ACh-induced tension of CLSMs in each group showed no significant difference. Conclusions FLCWK manifested curative effect in IBS-D rats by inhibiting colonic contraction. The underlying mechanisms may be related to regulatory pathway of nitric oxide/cGMP/Ca2+ and specific potassium channels.
Effect of dietary conjugated linoleic acid on body composition and energy balance in broiler chickens

The effect of dietary conjugated linoleic acid (CLA) on body composition and energy metabolism was investigated in broiler chickens. Male broiler chicks were assigned to receive either a control diet (1 % sunflower oil) or a diet containing CLA (1 % of a 1:1 mixture of trans-10, cis-12 and cis-9, trans-11 isomers of octadecadienoic acid). The diets were fed ad libitum for 3 weeks and there were eight replicates per diet, each replicate including four chickens so that each treatment had thirty-two animals. The proportion of body fat was lower in the control group than in the CLA group. No significant differences as to the proportions of body water, ash and protein were observed. Feed and energy intake were significantly lower in CLA-fed birds. The percentage of ingested energy lost in excreta was higher after CLA feeding and heat expenditure as a percentage of ingested energy was lower in the CLA-fed group. The CLA-fed group showed a higher percentage of SFA and lower percentages of MUFA and PUFA in carcass fat. It is concluded that CLA stimulated de novo fatty acid synthesis and lowered desaturase activity.
Reliable and Performant Identification of Low-Energy Conformers in the Gas Phase and Water

Prediction of compound properties from structure via quantitative structure-activity relationship and machine-learning approaches is an important computational chemistry task in small-molecule drug research. Though many such properties are dependent on three-dimensional structures or even conformer ensembles, the majority of models are based on descriptors derived from two-dimensional structures. Here we present results from a thorough benchmark study of force field, semiempirical, and density functional methods for the calculation of conformer energies in the gas phase and water solvation as a foundation for the correct identification of relevant low-energy conformers. We find that the tight-binding ansatz GFN-xTB shows the lowest error metrics and highest correlation to the benchmark PBE0-D3(BJ)/def2-TZVP in the gas phase for the computationally fast methods and that in solvent OPLS3 becomes comparable in performance. MMFF94, AM1, and DFTB+ perform worse, whereas the performance-optimized but far more expensive functional PBEh-3c yields energies almost perfectly correlated to the benchmark and should be used whenever affordable. On the basis of our findings, we have implemented a reliable and fast protocol for the identification of low-energy conformers of drug-like molecules in water that can be used for the quantification of strain energy and entropy contributions to target binding as well as for the derivation of conformer-ensemble-dependent molecular descriptors.