Miracle-dz/UniFAR-FTUs huggingface dataset:
Hormonal Treatment of Transgender Women with Oral Estradiol

Abstract Purpose: Maintaining cross-sex hormone levels in the normal physiologic range for the desired gender is the cornerstone of transgender hormonal therapy, but there are limited data on how to achieve this. We investigated the effectiveness of oral estradiol therapy in achieving this goal. Methods: We analyzed data on all transgender females seen in our clinic since 2008 treated with oral estradiol. We looked at the success of achieving serum levels of testosterone and 17-β estradiol in the normal range on various doses of estradiol (with and without antiandrogens spironolactone and finasteride). Results: There was a positive correlation between estradiol dose and 17-β estradiol, but testosterone suppression was less well correlated. Over 70% achieved treatment goals (adequate 17-β estradiol levels and testosterone suppression) on 4 mg daily or more. Nearly a third of patients did not achieve adequate treatment goals on 6 or even 8 mg daily of estradiol. Spironolactone, but not finasteride, use was associated with impairment of obtaining desired 17-β estradiol levels. Spironolactone did not enhance testosterone suppression, and finasteride was associated with higher testosterone levels. Conclusions: Oral estradiol was effective in achieving desired serum levels of 17-β estradiol, but there was wide individual variability in the amount required. Oral estradiol alone was not infrequently unable to achieve adequate testosterone suppression. Spironolactone did not aid testosterone suppression and seemed to impair achievement of goal serum 17-β estradiol levels. Testosterone levels were higher with finasteride use. We recommend that transgender women receiving estradiol therapy have hormone levels monitored so that therapy can be individualized.
Neural correlates underlying the attentional spotlight in human parietal cortex independent of task difficulty

Changes in the size of the attentional focus and task difficulty often co‐vary. Nevertheless, the neural processes underlying the attentional spotlight process and task difficulty are likely to differ from each other. To differentiate between the two, we parametrically varied the size of the attentional focus in a novel behavioral paradigm while keeping visual processing difficulty either constant or not. A behavioral control experiment proved that the present behavioral paradigm could indeed effectively manipulate the size of the attentional focus per se, rather than affecting purely perceptual processes or surface processing. Imaging results showed that neural activity in a dorsal frontoparietal network, including right superior parietal cortex (SPL), was positively correlated with the size of the attentional spotlight, irrespective of whether task difficulty was constant or varied across different sizes of attentional focus. In contrast, neural activity in the ventral frontoparietal network, including the right inferior parietal cortex (IPL), was positively correlated with increasing task difficulty. Data suggest that sub‐regions in parietal cortex are differentially involved in the attentional spotlight process and task difficulty: while SPL was involved in the attentional spotlight process independent of task difficulty, IPL was involved in the effect of task difficulty independent of the attentional spotlight process. Hum Brain Mapp 38:4996–5018, 2017. © 2017 Wiley Periodicals, Inc.
Clinico-microbiological Profile of Septic Diabetic Foot with Special Reference to Anaerobic Infection

Introduction Diabetic foot infections are a major cause of non-traumatic amputations. The role of anaerobes in the prognosis of these infections is particularly unclear. This study was conducted with the aim of correlating microbiological profiles with clinical outcomes in these diabetic foot ulcer patients. Methodology This prospective observational study was done in a tertiary care centre in South India. All patients admitted with diabetic foot ulcers for two years were included in the study. Tissue biopsies were collected from the ulcer for aerobic and anaerobic cultures. The patients were grouped as those with aerobic infection alone (anaerobe negative) and those with mixed aerobic and anaerobic infections (anaerobe positive). Anaerobic culture was performed using the Robertson cooked meat (RCM) medium. The ulcer of the foot was described with respect to site, size, duration, history of previous amputation(s), and history of number and class of antibiotic intake prior to hospitalization. Clinical course and Wagner’s grades of the diabetic foot ulcers were compared for aerobic and anaerobic infections. Results A total of 104 patients were included in the study. There were no significant differences between the two groups with regards to duration of diabetes, random blood sugar (RBS) at the time of admission, compliance to drugs, and mode of blood sugar control and prior intake of antibiotics. Patients with anaerobic infections were found to have a higher incidence of fever in this study (38.1% vs. 14.5%; p = 0.0057), as compared to patients with aerobic infections. More than half of the patients in the anaerobic infection group presented with Wagner’s grade IV and above, as compared to the aerobic infection group (59.5% vs. 32.2%; p = 0.0059), which was statistically significant. Patients with anaerobic infections also had high numbers of major and minor amputations when compared to patients with aerobic infections. Conclusion Septic diabetic foot patients with fever at the time of admission and a high Wagner’s grade have a greater chance of harbouring anaerobic infections. Drugs for anaerobic coverage should be considered for wounds beyond Wagner’s grade III. Anaerobic infections resulted in increased risk of morbidity in diabetic foot ulcer patients but did not have any influence on mortality.
On the Limitations of Unsupervised Bilingual Dictionary Induction

Unsupervised machine translation - i.e., not assuming any cross-lingual supervision signal, whether a dictionary, translations, or comparable corpora - seems impossible, but nevertheless, Lample et al. (2017) recently proposed a fully unsupervised machine translation (MT) model. The model relies heavily on an adversarial, unsupervised cross-lingual word embedding technique for bilingual dictionary induction (Conneau et al., 2017), which we examine here. Our results identify the limitations of current unsupervised MT: unsupervised bilingual dictionary induction performs much worse on morphologically rich languages that are not dependent marking, when monolingual corpora from different domains or different embedding algorithms are used. We show that a simple trick, exploiting a weak supervision signal from identical words, enables more robust induction and establish a near-perfect correlation between unsupervised bilingual dictionary induction performance and a previously unexplored graph similarity metric.
Determinants of regret in elderly dialysis patients

In Singapore, most elderly end‐stage renal disease (ESRD) patients choose dialysis over palliative management. However, dialysis may not be the optimal treatment option given only moderate survival benefits and high costs and treatment burden compared to non‐dialysis management. Elderly patients may therefore come to regret this decision. This study investigated: (i) extent of patients’ decision regret after starting dialysis, and (ii) potentially modifiable predictors of regret: satisfaction with chronic kidney disease education, decisional conflict, and decision‐making involvement.
External Dacryocystorhinostomy: Double-Flap Anastomosis or Excision of the Posterior Flaps?

Purpose: To compare the results of external dacryocystorhinostomy (DCR), using two different patterns of flap anastomosis with creation of both sac and nasal mucosal anterior and posterior flaps: one that includes suturing of both flaps and the other that involves excision of the posterior flaps. Methods: This randomized, clinical trial included 63 consecutive patients undergoing DCR. Patients were alternately assigned to two groups on the basis of the pattern of flap anastomosis. An H-shaped incision was created in the lacrimal sac and the nasal mucosa in all patients. In group A, posterior and anterior flaps were separately approximated; in group B, only the anterior flaps were sutured after resection of both posterior flaps. Postoperative hemorrhage, epiphora, and patency of the tract were assessed on follow-up visits. Final scores and success rates of the two groups were compared by using the Mann-Whitney U and &khgr;2. Results: The mean length of follow-up was 10.87 ± 4.75 months for all patients. One patient in group B was lost to follow-up. The difference between the groups in postoperative bleeding, epiphora, and patency scores was found to be statistically insignificant (p = 0.451, p = 0.974, p = 0.583, respectively). The final success rates in groups A and B were 93.75% and 96.67%, respectively. There was no statistically significant difference in success rate between the groups (p = 0.593). Conclusions: Our study suggests that DCR with double-flap anastomosis has no advantage over DCR with only anterior flaps. Anastomosis by suturing only anterior flaps and excision of the posterior flaps is easier to perform and does not appear to adversely affect the outcome of DCR surgery.
Molecular tracking of mountain lions in the Yosemite Valley region in California: genetic analysis using microsatellites and faecal DNA

Twelve microsatellite loci were characterized in California mountain lions (Puma concolor) and sufficient polymorphism was found to uniquely genotype 62 animals sampled at necropsy. Microsatellite genotypes obtained using mountain lion faecal DNA matched those from muscle for all of 15 individuals examined. DNA from potential prey species and animals whose faeces could be misidentified as mountain lion faeces were reliably distinguished from mountain lions using this microsatellite panel. In a field application of this technique, 32 faecal samples were collected from hiking trails in the Yosemite Valley region where seven mountain lions previously had been captured, sampled, and released. Twelve samples yielded characteristic mountain lion genotypes, three displayed bobcat‐type genotypes, and 17 did not amplify. The genotype of one of the 12 mountain lion faecal samples was identical to one of the mountain lions that previously had been captured. Three of the 12 faecal samples yielded identical genotypes, and eight new genotypes were detected in the remaining samples. This analysis provided a minimum estimate of 16 mountain lions (seven identified by capture and nine identified by faecal DNA) living in or travelling through Yosemite Valley from March 1997 to August 1998. Match probabilities (probabilities that identical DNA genotypes would be drawn at random a second time from the population) indicated that the samples with identical genotypes probably came from the same mountain lion. Our results demonstrate that faecal DNA analysis is an effective method for detecting and identifying individual mountain lions.
TGF-β induces changes in breast cancer cell deformability

Mechanical properties of cells are shown to regulate cell behaviors leading to phenotypic changes that may aid in the development and progression of disease. In this study, we used atomic force microscopy (AFM) indentation with a spherical probe to characterize the elastic and viscoelastic properties of invasive (MDA-MB-231) and noninvasive (MCF-7) breast cancer cells treated with transforming growth factor-β (TGF-β). We also used confocal fluorescence imaging to investigate the sub-membrane cytoskeletal structure of the cells. Results showed significant alterations in moduli of both cell types after 24 h TGF-β treatment which had a context dependent response; moduli for MDA-MB-231 decreased whereas MCF-7 demonstrated stiffening response. Stress relaxation tests showed increased fluid-like nature of MDA-MB-231 following TGF-β treatment and lower fluidity for MCF-7 cells. We also observed significant alterations in the expression and orientation of actin stress fibers with TGF-β treatment which correlated with the changes in cell mechanics. Less invasive MCF-7 cells had a delayed overall increase in cell deformability after 48 h exposure to TGF-β; a similar trend was observed for MDA-MB cells. These changes may be important to facilitate migration, for instance, during metastasis of cancer cells through submicron sized spaces.
T784C LNK gene polymorphism and the risk of myeloproliferative disorders

Igor A. Olkhovskiy , Aleksey S. Gorbenko , Marina A. Stolyar , Evgeniy V. Vasiliev , Mikhail A. Mikhalev and Kseniya A. Tabakova Krasnoyarsk Branch of the “National Research Center for Hematology”, Krasnoyarsk, Russian Federation; Federal Research Center Krasnoyarsk Scientific Center of the Siberian Branch of the Russian Academy of Sciences, Krasnoyarsk, Russian Federation; Krasnoyarsk Regional Clinic Hospital, Krasnoyarsk, Russian Federation; Krasnoyarsk City Clinical Hospital @7, Krasnoyarsk, Russian Federation; Siberian Federal University, Krasnoyarsk, Russian Federation
The First 100 Milliseconds of a Face: On the Microgenesis of Early Face Processing

Face recognition involves both processing of information relating to features (e.g., eyes, nose, mouth, hair, i.e., featural processing), as well as the spatial relation between these features (configural processing). In a sequential matching task, participants had to decide whether two faces that differed in either featural or relational aspects were identical or different. In order to test for the microgenesis of face recognition (the development of processing onsets), presentation times of the backward-masked target face were varied (32, 42, 53, 63, 74, 84, or 94 msec.). To test for specific processing onsets and the processing of different facial areas, both featurally and relationally modified faces were manipulated in terms of changes to one facial area (eyes or nose or mouth), two, or three facial areas. For featural processing, an early onset for the eyes and mouth was at 32 msec. of presentation time, but a late onset for the nose was detected. For relationally differing faces, all onsets were delayed.
Flexible-Latency DRAM: Understanding and Exploiting Latency Variation in Modern DRAM Chips

This article summarizes key results of our work on experimental characterization and analysis of latency variation and latency-reliability trade-offs in modern DRAM chips, which was published in SIGMETRICS 2016, and examines the work's significance and future potential. The goal of this work is to (i) experimentally characterize and understand the latency variation across cells within a DRAM chip for these three fundamental DRAM operations, and (ii) develop new mechanisms that exploit our understanding of the latency variation to reliably improve performance. To this end, we comprehensively characterize 240 DRAM chips from three major vendors, and make six major new observations about latency variation within DRAM. Notably, we find that (i) there is large latency variation across the cells for each of the three operations; (ii) variation characteristics exhibit significant spatial locality: slower cells are clustered in certain regions of a DRAM chip; and (iii) the three fundamental operations exhibit different reliability characteristics when the latency of each operation is reduced. Based on our observations, we propose Flexible-LatencY DRAM (FLY-DRAM), a mechanism that exploits latency variation across DRAM cells within a DRAM chip to improve system performance. The key idea of FLY-DRAM is to exploit the spatial locality of slower cells within DRAM, and access the faster DRAM regions with reduced latencies for the fundamental operations. Our evaluations show that FLY-DRAM improves the performance of a wide range of applications by 13.3%, 17.6%, and 19.5%, on average, for each of the three different vendors' real DRAM chips, in a simulated 8-core system.
Screening for risk of violence using service users’ self‐perceptions: A prospective study from an acute mental health unit

Service users' self-perception of risk has rarely been emphasized in violence risk assessments. A recent review pointed to the importance of a multidisciplinary approach, because different perspectives may provide a deeper and improved understanding of risk assessment. The aim of this study was to investigate service users' perceptions of their own risk of committing violence, using a self-report risk scale, to determine the feasibility and efficacy of this potential violence risk marker during acute mental health hospitalization. All service users admitted to a psychiatric emergency hospital in Norway during one calendar year were included (N = 512). Nearly 80% self-reported no risk or low risk; only seven (1.4%) reported moderate risk or high risk. Service users who reported moderate risk, high risk, don't know, or won't answer were more likely to be violent (OR = 4.65, 95% CI = 2.79-7.74) compared with those who reported no risk or low risk. There was a significant gender interaction with higher OR for women on both univariate and multivariate analyses. Although the OR was higher for women, women's violence rate (11.0%) was almost half that of men (21.8%). For women, sensitivity and specificity were 0.55 and 0.88, respectively; corresponding values for men were 0.40 and 0.80. Inclusion of self-perception of violence risk is the first step towards service users' collaborative involvement in violence prediction; these results indicate that self-perception can contribute to violence risk assessments in acute mental health settings. Findings also indicate that there are gender differences in these assessments.
Nature and origins of the lexicon in 6-mo-olds

Significance Infants start understanding words at 6 mo, when they also excel at subtle speech–sound distinctions and simple multimodal associations, but don’t yet talk, walk, or point. However, true word learning requires integrating the speech stream with the world and learning how words interrelate. Using eye tracking, we show that neophyte word learners already represent the semantic relations between words. We further show that these same infants’ word learning has ties to their environment: The more they hear labels for what they’re looking at and attending to, the stronger their overall comprehension. These results provide an integrative approach for investigating home environment effects on early language and suggest that language delays could be detected in early infancy for possible remediation. Recent research reported the surprising finding that even 6-mo-olds understand common nouns [Bergelson E, Swingley D (2012) Proc Natl Acad Sci USA 109:3253–3258]. However, is their early lexicon structured and acquired like older learners? We test 6-mo-olds for a hallmark of the mature lexicon: cross-word relations. We also examine whether properties of the home environment that have been linked with lexical knowledge in older children are detectable in the initial stage of comprehension. We use a new dataset, which includes in-lab comprehension and home measures from the same infants. We find evidence for cross-word structure: On seeing two images of common nouns, infants looked significantly more at named target images when the competitor images were semantically unrelated (e.g., milk and foot) than when they were related (e.g., milk and juice), just as older learners do. We further find initial evidence for home-lab links: common noun “copresence” (i.e., whether words’ referents were present and attended to in home recordings) correlated with in-lab comprehension. These findings suggest that, even in neophyte word learners, cross-word relations are formed early and the home learning environment measurably helps shape the lexicon from the outset.
Treatment efficacy of probiotics on atopic dermatitis, zooming in on infants: a systematic review and meta‐analysis

Probiotic treatment of atopic dermatitis is widely studied with controversial results. The objective of this study is to review the efficacy of probiotics for the treatment of atopic dermatitis in infants. PubMed, Embase, and Cochrane Central Register of Controlled Trials databases, and reference lists were searched up to July 2017. Double‐blinded randomized clinical trials were included. The primary outcome was the Scoring Atopic Dermatitis index. Subgroups analyses were conducted on probiotic species, treatment duration, participant age, and disease severity. Eight clinical trials (741 infants) were included in the quantitative synthesis. The overall pooled change in Scoring Atopic Dermatitis index (95% CI) in infants was −5.71 (−8.37, −3.04), P < 0.01. Subgroup analysis revealed that the effect was protective in moderate‐to‐severe patients −8.32 (−16.35, −0.28), with preparations containing Lactobacillus −5.76 (−9.21, −2.30). Probiotics for the treatment of infantile atopic dermatitis is beneficial.
Money, Sex and Self-Control: Predicting the Disposition Effect?

The widely-observed behavior of holding losing stocks longer than winning ones, is known as the disposition effect. This failure to realise paper losses is a major cause of eventual loss in investing. There is increasing evidence that financial choices, particularly those where there is threat of loss, such as the disposition effect, could be related to elements of psychophysiology. There is a well-known relationship between the psychophysiological and behavioral responses to threat and aspects of autonomic nervous system function. This study investigates the relationship between failure to realise paper losses during simulated stock trading and autonomic nervous system function as indexed by heart rate variability (HRV). Resting HRV was measured before participants played a stock trading game. After playing, a disposition effect index (DEX) was calculated for each player, from the time spent in losing stocks, as a proportion of total time in the market. HRV, specifically, a high level of high frequency HRV (HFHRV), is known to be significantly associated with reduced inappropriate responsiveness to threat, and inhibition of arousal. The group showed a significant inverse correlation between HF HRV ( %HRV) and DEX. This was carried mostly by males. Men who had a faster heart rate at baseline also held losing stocks longer, as did those with a higher LF/HF ratio. Men who have high HFHRV are more able to exert parasympathetic control over arousal, and are less likely to stay in losing stocks in a stock market trading game. The gender difference in correlations may be related to gender-specific responses to threat.