Miracle-dz/UniFAR-FTUs huggingface dataset:
Analytic Element Modeling of Steady Interface Flow in Multilayer Aquifers Using AnAqSim

This paper presents the analytic element modeling approach implemented in the software AnAqSim for simulating steady groundwater flow with a sharp fresh‐salt interface in multilayer (three‐dimensional) aquifer systems. Compared with numerical methods for variable‐density interface modeling, this approach allows quick model construction and can yield useful guidance about the three‐dimensional configuration of an interface even at a large scale. The approach employs subdomains and multiple layers as outlined by Fitts (2010) with the addition of discharge potentials for shallow interface flow (Strack 1989). The following simplifying assumptions are made: steady flow, a sharp interface between fresh‐ and salt water, static salt water, and no resistance to vertical flow and hydrostatic heads within each fresh water layer. A key component of this approach is a transition to a thin fixed minimum fresh water thickness mode when the fresh water thickness approaches zero. This allows the solution to converge and determine the steady interface position without a long transient simulation. The approach is checked against the widely used numerical codes SEAWAT and SWI/MODFLOW and a hypothetical application of the method to a coastal wellfield is presented.
Chapter 10 Management of In-Transit Malignant Melanoma

In-transit melanoma is a unique pattern of recurrence that occurs in up to ten percent of pa‐ tients with melanoma. In-transit disease denotes multifocal tumor deposits occurring be‐ tween the site of the primary lesion and its regional draining lymph node basin [1, 2]. It is an independent adverse prognostic factor and is frequently associated with distant metastasis. This pattern of recurrence represents a challenging management problem, but provides unique treatment modalities as well. In addition, studying in-transit melanoma has the po‐ tential to shed additional light on melanoma biology. The goal of this chapter is to discuss the presentation, underlying disease biology, and various current treatment strategies for this unique pattern of recurrence in melanoma.
Socioeconomic status and trends in disparities in 4 major risk factors for cardiovascular disease among US adults, 1971-2002.

BACKGROUND It is unknown whether the previously recognized disparities in cardiovascular disease (CVD) risk factors related to annual income and educational level have diminished, persisted, or worsened in recent decades. The objective of this study was to examine 31-year trends in CVD risk factors by annual income and educational levels among US adults. METHODS Four cross-sectional national surveys were used: National Health and Nutrition Examination Survey I (1971-1974), II (1976-1980), III (1988-1994), and 1999-2002. The main outcome measure was prevalence of high cholesterol (> or =240 mg/dL [> or =6.2 mmol/L]), high blood pressure (140/90 mm Hg), smoking, and diabetes mellitus. RESULTS Between 1971 and 2002, the prevalence of all CVD risk factors, except diabetes, decreased in all income and education groups, but there has been little reduction in income- and education-related disparities in CVD risk factors and few improvements during the past 10 years. The prevalence of high blood pressure declined by about half in all income and education groups, ranging from 30.3% to 40.6% in 1971-1974 and 16.4% in 1999-2002, with the greatest reduction among those in the lowest income quartile and those with less than a high school education (18.0 and 15.9 percentage points, respectively). High cholesterol prevalence also declined in all groups and ranged from 28.8% to 32.4% in 1971-1974 and 15.3% to 22.0% in 1999-2002, with the largest decline (15.9 percentage points) among people with the highest incomes. Education- and income-related disparities in smoking widened considerably, because there were large declines in smoking prevalence among people with high incomes and education (from about 33% in 1971-1974 to about 14%-17% in 1999-2002) but only marginal reductions among those with low incomes and education (about 6-percentage point decline). Diabetes prevalence increased most among persons with low incomes and education. CONCLUSIONS Despite the general success in reducing CVD risk factors in the US population, not all segments of society are benefiting equally and improvements may have slowed. Education- and income-related disparities have worsened for smoking, and increases in diabetes prevalence have occurred primarily among persons with a lower socioeconomic status. Diabetes prevention and smoking prevention and cessation programs need to specifically target persons of lower income and education.
Low Dose Cranial Irradiation-Induced Cerebrovascular Damage Is Reversible in Mice

Background High-dose radiation-induced blood-brain barrier breakdown contributes to acute radiation toxicity syndrome and delayed brain injury, but there are few data on the effects of low dose cranial irradiation. Our goal was to measure blood-brain barrier changes after low (0.1 Gy), moderate (2 Gy) and high (10 Gy) dose irradiation under in vivo and in vitro conditions. Methodology Cranial irradiation was performed on 10-day-old and 10-week-old mice. Blood-brain barrier permeability for Evans blue, body weight and number of peripheral mononuclear and circulating endothelial progenitor cells were evaluated 1, 4 and 26 weeks postirradiation. Barrier properties of primary mouse brain endothelial cells co-cultured with glial cells were determined by measurement of resistance and permeability for marker molecules and staining for interendothelial junctions. Endothelial senescence was determined by senescence associated β-galactosidase staining. Principle Findings Extravasation of Evans blue increased in cerebrum and cerebellum in adult mice 1 week and in infant mice 4 weeks postirradiation at all treatment doses. Head irradiation with 10 Gy decreased body weight. The number of circulating endothelial progenitor cells in blood was decreased 1 day after irradiation with 0.1 and 2 Gy. Increase in the permeability of cultured brain endothelial monolayers for fluorescein and albumin was time- and radiation dose dependent and accompanied by changes in junctional immunostaining for claudin-5, ZO-1 and β-catenin. The number of cultured brain endothelial and glial cells decreased from third day of postirradiation and senescence in endothelial cells increased at 2 and 10 Gy. Conclusion Not only high but low and moderate doses of cranial irradiation increase permeability of cerebral vessels in mice, but this effect is reversible by 6 months. In-vitro experiments suggest that irradiation changes junctional morphology, decreases cell number and causes senescence in brain endothelial cells.
qNVRAM: quasi Non-Volatile RAM for Low Overhead Persistency Enforcement in Smartphones

The persistent storage options in smartphones employ journaling or double-write to enforce atomicity, consistency and durability, which introduces significant overhead to system performance. Our in-depth examination of the issue leads us to believe that much of the overhead would be unnecessary if we rethink the volatility of memory considering the battery-backed characteristics of DRAM in modern-day smartphones. With this rethinking, we propose quasi Non-Volatile Memory (qNVRAM), a new design that makes the DRAM in smartphones quasi non-volatile, to help remove the performance overhead of enforcing persistency. We assess the feasibility and effectiveness of our design by implementing a persistent page cache in SQLite. Our evaluation on a real Android smartphone shows that qNVRAM speeds up the insert, update and delete transactions by up to 16.33×, 15.86× and 15.76× respectively.
Evaluation of the Mine-Merge Method for Data Mining Query Processing

In this paper we consider concurrent execution of multiple data mining queries in the context of discovery of frequent itemsets. If such data mining queries operate on similar parts of the database, then their overall I/O cost can be reduced by transforming the set of data mining queries into another set of non-overlapping queries, whose results can be used to efficiently answer the original queries. We discuss the problem of multiple data mining query optimization and experimentally evaluate the Mine Merge algorithm to efficiently execute sets of data mining queries.
Understanding the factors influencing user experience in social question and answer services

Introduction. The popularity of social question and answer sites has made it an important and convenient source for obtaining knowledge. This study quantifies how three different system characteristics (interface design, interaction and answer quality) affect users' perceptions (perceived usefulness, perceived ease of use and perceived enjoyment), which in turn alter the perceived user experience. Method. Using an online survey, this study investigated the experience of using a leading Chinese site, Baidu Knows. The study received 218 validated responses which were used to test the research model. Analysis. Structural equation modelling technique was used to evaluate the hypothesised research framework. Results. The results show that the influences of the system characteristics (interface design, interaction and answer quality) on user experience are well mediated by user perceptions of usefulness, ease of use and enjoyment. Additionally, perceived usefulness and perceived enjoyment have direct and significant influences on user experience. Against expectations, perceived ease of use is found to have no significant direct effect on user experience, but have an indirect effect mediated through perceived usefulness. Conclusion. Use experience is mainly determined by user perceptions about its usefulness,the ease of use and the enjoyment of using the social question and answer sites, which are derived from their evaluation in relation to specific service features. By identifying these service features and quantifying how they affect user experience, a number of practical suggestions for service design have been made to help social question and answer sites managers improve their customers' user experience, e.g. offering more attractive rewards and adding various entertainment activities to motivate users to actively participate in knowledge sharing and innovation.
Computer Literacy in Baccalaureate Nursing Students During the Last 8 Years

With the rapid integration of information technology in the healthcare field, equipping nurses with skills to effectively use the technology is vital. Evaluations of nursing students' nursing informatics competencies are scarce in nursing programs as reported in the literature. The current study was implemented to evaluate the self-reported nursing informatics competence of undergraduate baccalaureate students upon admission and graduation in the years from 1997 to 2005 and to compare the differences between admission and graduation. The Gassert/McDowell Computer Literacy Survey was used to survey 411 students on admission and 429 students on graduation from a baccalaureate nursing program. Results showed a significant increase during the 8-year period, both on admission and graduation, for reported level of experience with word processing, electronic mail, and World Wide Web. Areas of less experience that did not increase significantly were spreadsheet experience, database experience, and use of statistical programs. The nursing informatics competencies established for beginning nurses include databases, spreadsheets, word processing, presentation graphics, and keyboard skills. The results of this study indicate nursing education programs currently may not be providing beginning nurses with the tools needed to effectively and efficiently work in the technology-rich healthcare arena.
Human parvovirus B19 infection in patients with chronic hepatitis B or hepatitis C infection

Background and Aim: Parvovirus B19 has been reported to be detected in the sera of patients with acute or chronic hepatitis. The prevalence and clinical significance of B19 DNA in serum samples from patients with chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infection were investigated.
Ulinastatin attenuates oxidation, inflammation and neural apoptosis in the cerebral cortex of adult rats with ventricular fibrillation after cardiopulmonary resuscitation

OBJECTIVE: The role of Ulinastatin in neuronal injury after cardiopulmonary resuscitation has not been elucidated. We aim to evaluate the effects of Ulinastatin on inflammation, oxidation, and neuronal injury in the cerebral cortex after cardiopulmonary resuscitation. METHODS: Ventricular fibrillation was induced in 76 adult male Wistar rats for 6 min, after which cardiopulmonary resuscitation was initiated. After spontaneous circulation returned, the rats were split into two groups: the Ulinastatin 100,000 unit/kg group or the PBS-treated control group. Blood and cerebral cortex samples were obtained and compared at 2, 4, and 8 h after return of spontaneous circulation. The protein levels of tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6) were assayed using an enzyme-linked immunosorbent assay, and mRNA levels were quantified via real-time polymerase chain reaction. Myeloperoxidase and Malondialdehyde were measured by spectrophotometry. The translocation of nuclear factor-κB p65 was assayed by Western blot. The viable and apoptotic neurons were detected by Nissl and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL). RESULTS: Ulinastatin treatment decreased plasma levels of TNF-α and IL-6, expression of mRNA, and Myeloperoxidase and Malondialdehyde in the cerebral cortex. In addition, Ulinastatin attenuated the translocation of nuclear factor-κB p65 at 2, 4, and 8 hours after the return of spontaneous circulation. Ulinastatin increased the number of living neurons and decreased TUNEL-positive neuron numbers in the cortex at 72 h after the return of spontaneous circulation. CONCLUSIONS: Ulinastatin preserved neuronal survival and inhibited neuron apoptosis after the return of spontaneous circulation in Wistar rats via attenuation of the oxidative stress response and translocation of nuclear factor-κB p65 in the cortex. In addition, Ulinastatin decreased the production of TNF-α, IL-6, Myeloperoxidase, and Malondialdehyde.
Gender and Culture in Newspaper Column Writing

This study examines differences between male and female as well as UK and US authors in newspaper text, specifically column writing. Many studies have shown that women have a tendency to show greater involvement in text by using personal and subjective reference. The present study applied corpus linguistic methods to 145 columns retrieved from two broadsheet newspapers, The Guardian and The New York Times . The usage of first person singular and plural pronouns was examined to determine whether there are gender-based or cultural differences in the way the authors show involvement in the texts. The data show no significant differences between male and female or UK and US authors. The uneven gender distribution of the sampling, conventions of journalism and column writing as well as women’s adaptation to the communication style of public sphere may be some of the reasons for the non-significant differences between the studied dimensions.
Anatomical and functional graft survival, 10 years after epikeratoplasty in keratoconus

Purpose: To report outcomes of epikeratoplasty in keratoconus (KC), utilizing manually-prepared plano donor lenticules in terms of flattening of the cone, reduction in astigmatism and improvement in the visual acuity. Materials and Methods: Patients with KC, having visual acuity <20/200, astigmatism >12 diopters (D) but without corneal opacity underwent epikeratoplasty, using manually prepared plano donor lenticules from fresh or M.K preserved corneas, between 1990 - 2000 and followed for 10 years, were included in this report. Visual acuity slit-lamp-biomicroscopy, keratometry, and refraction were performed at 8 weeks, 12 weeks, and 6 months for all 59 patients. The same were carried out at 1 year, 5 years, and 10 years depending upon the availability of the patient for that period. Results: Of the 59 patients, only 26 were available for follow-up after 10 years. At 3 months, 1 year and 5 years, best corrected visual acuity of (BCVA) ≥20/60 were achieved in 84.7%, 84.4% and 80.3% of eyes, respectively. BCVA was 73% at 10-year follow- up, which was due to the presence of posterior subcapsular cataract (PSC). The average keratometric astigmatism and average flattening in diopters stabilized at the end of 3 months, which remained constant at 1, 5, and 10-year follow-up. The average diopter of myopia was stabilized by 1 year, which was almost same at 10 year. Graft was clear in all but 1 eye at 10 year follow-up. Conclusion: Epikeratoplasty is a useful technique for keratoconic eyes without apical scarring who fail or unable to use contact lenses.
Handling Correlations Between Covariates and Random Slopes in Multilevel Models

This article discusses estimation of multilevel/hierarchical linear models that include cluster-level random intercepts and random slopes. Viewing the models as structural, the random intercepts and slopes represent the effects of omitted cluster-level covariates that may be correlated with included covariates. The resulting correlations between random effects (intercepts and slopes) and included covariates, which we refer to as “cluster-level endogeneity,” lead to bias when using standard random effects (RE) estimators such as (restricted) maximum likelihood. While the problem of correlations between unit-level covariates and random intercepts is well known and can be handled by fixed-effects (FE) estimators, the problem of correlations between unit-level covariates and random slopes is rarely considered. When applied to models with random slopes, the standard FE estimator does not rely on standard cluster-level exogeneity assumptions, but requires an “uncorrelated variance assumption” that the variances of unit-level covariates are uncorrelated with their random slopes. We propose a “per-cluster regression” (PC) estimator that is straightforward to implement in standard software, and we show analytically that it is unbiased for all regression coefficients under cluster-level endogeneity and violation of the uncorrelated variance assumption. The PC, RE, and an augmented FE estimator are applied to a real data set and evaluated in a simulation study that demonstrates that our PC estimator performs well in practice.
Determination of the Hubble Constant, the Intrinsic Scatter of Luminosities of Type Ia Supernovae, and Evidence for Nonstandard Dust in Other Galaxies

A sample of 109 Type Ia supernovae (SNe Ia) with recession velocity ≲30,000 km s-1 is compiled from published SN Ia light curves to explore the expansion rate of the local universe. Based on the color parameter ΔC12 and the decline rate Δm15, we found that the average absorption-to-reddening ratios for SN Ia host galaxies are RUBVI = 4.37 ± 0.25, 3.33 ± 0.11, 2.30 ± 0.11, and 1.18 ± 0.11, which are systematically lower than the standard values in the Galaxy. We investigated the correlations of the intrinsic luminosity with light-curve decline rate, color index, and SN environmental parameters. In particular, we found that SNe Ia in E/S0 galaxies close to the central region are brighter than those in the outer region, which may suggest a possible metallicity effect on SN luminosity. The dependence of SN luminosity on galactic environment disappears after corrections for the extinction and ΔC12. The Hubble diagrams constructed using 73 Hubble flow SNe Ia yield a 1 σ scatter of ≲0.12 mag in BVI bands and ~0.16 mag in U band. The luminosity difference between normal SNe Ia and peculiar objects (including SN 1991bg-like and SN 1991T-like events) has now been reduced to within 0.15 mag via ΔC12 correction. We use the same precepts to correct the nearby SNe Ia with Cepheid distances and found that the fully corrected absolute magnitudes of SNe Ia are MB = -19.33 ± 0.06 and MV = -19.27 ± 0.05. We deduced a value for the Hubble constant of H0 = 72 ± 6 (total) km s-1 Mpc-1.
Writing, Reading, and Listening Differentially Overload Working Memory Performance Across the Serial Position Curve

Previous research has assumed that writing is a cognitively complex task, but has not determined if writing overloads Working Memory more than reading and listening. To investigate this, participants completed three recall tasks. These were reading lists of words before recalling them, hearing lists of words before recalling them, and hearing lists of words and writing them as they heard them, then recalling them. The experiment involved serial recall of lists of 6 words. The hypothesis that fewer words would be recalled overall when writing was supported. Post-hoc analysis revealed the same pattern of results at individual serial positions (1 to 3). However, there was no difference between the three conditions at serial position 4, or between listening and writing at positions 5 and 6 which were both greater than recall in the reading condition. This suggests writing overloads working memory more than reading and listening, particularly in the early serial positions. The results show that writing interferes with working memory processes and so is not recommended when the goal is to immediately recall information.
Do Early Dental Visits Reduce Treatment and Treatment Costs for Children?

PURPOSE The purpose of this paper was to determine if number and cost of dental treatments in high caries-risk children differs in children with early dental intervention compared to children with later intervention. METHODS Billing data from children age zero to seven years old, whose first dental visit was between January 1, 2004 and December 31, 2004, were collected from 20 corporate treatment centers serving children from lower socioeconomic status backgrounds. Data included age at first visit, dental treatment codes, and associated costs for eight years after the first dental visit. Treatment included restorations, crowns, pulpotomies, and extractions. First visit age was categorized into early starters (younger than four years old) and late starters (four years of age or older). Linear regression with cluster adjustment for clinic determined a difference in costs and dental treatments by early and late starters. RESULTS Of 42,532 subjects, 17,040 (40 percent) were early starters and 25,492 (60 percent) were late starters. There were 3.58 more dental procedures per- formed on late starters, over eight years of follow-up, than on early starters (P < .001). Late starters spent $360 more over eight years of follow-up than early starters (P < .001). CONCLUSION In this study, number of procedures per- formed were fewer and cost of treatment less for children seen earlier versus later.