Miracle-dz/UniFAR-FTUs huggingface dataset:
The rise and fall in incidence of malignant mesothelioma from a British Naval Dockyard, 1979-1999.

BACKGROUND The incidence of malignant mesothelioma in Britain is predicted to rise over the next 15-25 years because of past failure to protect the workforce against inhalation of asbestos. In British Naval dockyards, alternative insulation materials and respiratory protection were introduced from the mid-1960s. Aims This study was carried out to investigate the effects of these control measures on mesothelioma deaths in dockyard workers. METHODS Cases of mesothelioma of the pleura and peritoneum between 1979 and 1999 in workers from the Devonport Naval Dockyard, south-west England, were sought from coroners' and medico-legal records. RESULTS Three hundred and one cases were identified, 7% peritoneal. The peak incidence occurred in 1991 with 25 cases per annum (quadratic model fit R(2) = 74.2%, P < 0.001) and we predict that by 2003 the incidence will fall to fewer than five cases per annum. The mean time between first exposure and presentation was 48.5 years [95% confidence interval (CI) = 47.3-49.8], but this was significantly shorter in the more heavily exposed trades, when compared with the less heavily exposed (42 years, 95% CI = 39.0-45.0, versus 49.5 years, 95% CI = 48.2-50.9). Those with higher exposure were also at significantly greater risk of peritoneal disease (P < 0.023, Fisher's exact test). CONCLUSION The reduction in incidence of mesothelioma is greater than can be accounted for by reduction in numbers of dockyard workers over the last 50 years. Changes in insulation materials and improved industrial hygiene measures introduced into the Devonport Dockyard from the mid-1960s have resulted in an earlier decline in the incidence of malignant mesothelioma than that predicted for the British workforce as a whole.
Disruption of endothelial microfilaments selectively reduces the transendothelial migration of monocytes.

The transendothelial migration of leukocytes (diapedesis) is a central event in inflammatory and immunological processes. Although leukocyte-endothelium interactions occurring during diapedesis have been investigated intensively, little is known about the actual transmigration and the molecular mechanisms involved. Toward this end we analyzed whether the endothelial cytoskeleton plays a direct role during the transendothelial migration of monocytes. Filter-grown monolayers of human microvascular endothelial cells (HMEC-1) were treated with cytoskeleton stabilizing or destabilizing drugs and the effect of this treatment on the transmigration of peripheral blood monocytes was analyzed in a two-chamber assay. Our results show that taxol-induced stabilization of microtubules causes a reduction of leukocyte transmigration through HMEC-1, while the opposite effect is induced by the destabilization of microtubules with colchicine or nocodazol. Disruption of microfilaments with cytochalasin B or latrunculin A, on the other hand, significantly reduces the transendothelial migration although monocyte adhesion and endothelial permeability for macromolecules are slightly increased. An active participation of the endothelial microfilament system with a direct role of unconventional, calmodulin-regulated myosins is suggested by the finding that monocyte transmigration is decreased upon treatment of the endothelial cells with the Ca2+/CaM antagonist triflouperazine.
Components of Cell-Matrix Linkage as Potential New Markers for Prostate Cancer

Prostate cancer is one of the most common tumor diseases worldwide. Often being non-aggressive, prostate tumors in these cases do not need immediate treatment. However, about 20% of diagnosed prostate cancers tend to metastasize and require treatment. Existing diagnostic methods may fail to accurately recognize the transition of a dormant, non-aggressive tumor into highly malignant prostate cancer. Therefore, new diagnostic tools are needed to improve diagnosis and therapy of prostate carcinoma. This review evaluates existing methods to diagnose prostate carcinoma, such as the biochemical marker prostate-specific antigen (PSA), but also discusses the possibility to use the altered expression of integrins and laminin-332 in prostate carcinomas as diagnostic tools and therapeutic targets of prostate cancer.
Emerging therapies and challenges in spinal muscular atrophy

Spinal muscular atrophy (SMA) is a hereditary neurodegenerative disease with severity ranging from progressive infantile paralysis and premature death (type I) to limited motor neuron loss and normal life expectancy (type IV). Without disease‐modifying therapies, the impact is profound for patients and their families. Improved understanding of the molecular basis of SMA, disease pathogenesis, natural history, and recognition of the impact of standardized care on outcomes has yielded progress toward the development of novel therapeutic strategies and are summarized. Therapeutic strategies in the pipeline are appraised, ranging from SMN1 gene replacement to modulation of SMN2 encoded transcripts, to neuroprotection, to an expanding repertoire of peripheral targets, including muscle. With the advent of preliminary trial data, it can be reasonably anticipated that the SMA treatment landscape will transform significantly. Advancement in presymptomatic diagnosis and screening programs will be critical, with pilot newborn screening studies underway to facilitate preclinical diagnosis. The development of disease‐modifying therapies will necessitate monitoring programs to determine the long‐term impact, careful evaluation of combined treatments, and further acceleration of improvements in supportive care. In advance of upcoming clinical trial results, we consider the challenges and controversies related to the implementation of novel therapies for all patients and set the scene as the field prepares to enter an era of novel therapies. Ann Neurol 2017;81:355–368
Cardiac cell networks on elastic microgrooved scaffolds

We sought to construct a model-engineered cardiac construct having anisotropic properties and consisting of inter-connected cardiac cells with syncytial tissuelike behavior. We report basic structural, electrophysiological and mechanical characterization of multicellular tissuelike engineered constructs developed using elastic matrices with 3-D surface microtopography. To properly assess functionality of the constructs in the tissue setting, we employed spatial optical fluorescence techniques enabling measurements at the micro- and macro-scale.
Liver Total Glycogen, Mitochondrial Protein and CoQ10 Analysis in CoQ10 Supplemented Broiler Chicken

ISSN: 2319-7706 Volume 8 Number 04 (2019) Journal homepage: http://www.ijcmas. com A Pilot study was conducted to find out the level of CoQ10 inclusion in broiler diet to bring about better performance and conducted during the period from November to December. Fifty numbers of day old broiler straight run chicks were wing banded, weighed and randomly allotted to five groups of ten chicks each based on the body weight. The treatments include, 20mg, 40mg, 60mg, 80mg, 100mg of CoQ10/kg diet. Based on the results of FCR in pilot study experiment II was conducted with Two hundred and forty (240) numbers of day old broiler straight run chicks were wing banded, weighed and randomly allotted to 5 groups 6 replicates of eight chicks each based on the body weight. The treatments were, Basal diet without CoQ10 supplementation, Low energy diet without CoQ10 supplementation, Low energy diet with 20mg of CoQ10/kg diet, Low energy diet with 40mg of CoQ10/kg diet, Low energy diet with 60mg of CoQ10 /kg diet. Glycogen content of the liver was estimated as per the method of Seifter et al., (1949). Hepatic mitochondria were obtained by differential centrifugation as outlined by Cawthon et al., (1999). Mitochondrial protein concentration was estimated as per the method of Lowry et al., (1971). The CoQ10 content of liver was extracted as per the method of (Barros et al., 2011) and liver CoQ10 level was estimated as per the method of (Ioana et al., 2009). The mean liver glycogen (μg/g) was 152.66, 167.55, 169.14, 171.13 in the treatment groups T2 to T5 as compared with 158.45 in the control group of broiler chickens. The mean liver glycogen was significantly (P˂0.05) highest in the Co Q10 supplemented groupof birds (T3, T4 and T5) in comparison to control and T2 group. There was no significant difference in mean liver glycogen among the treatment groups T4 and T5. The mean liver glycogen was significantly (P˂0.05) lowest in the control and T2 group of birds. The mean liver mitochondrial protein concentration (μg/g) was 15.90, 24.70, 22.00 and 23.20 in the treatment groups T2 to T5 as compared with 19.70 in the control group of broiler chickens. The mean liver mitochondrial protein concentration was significantly (P˂0.05) highest in the CoQ10 supplemented group of birds (T3, T4 and T5) in comparison to control and T2 groups. The mean liver CoQ10 (mg/kg) was 49.26, 54.53, 55.75 and 55.74 in the treatment groups as compared with 53.83 in the control group of chicken. K e y w o r d s
Pregnancy outcome after in utero exposure to itraconazole: a prospective cohort study.

OBJECTIVE This study was undertaken to determine whether itraconazole use during the first trimester of pregnancy was associated with increased risks of major malformations, spontaneous abortions, premature deliveries, and neonatal complications. STUDY DESIGN In a prospective cohort study pregnant women exposed to oral itraconazole were matched with control subjects not exposed to any known teratogens. Primary outcome was the rate of major malformations. Secondary outcomes were live birth rate, rates of spontaneous abortion and therapeutic abortion, gestational age at delivery, birth weight, and neonatal complications. RESULTS A total of 229 women exposed to itraconazole were reported to the manufacturer, 198 of whom used the drug during the first trimester of pregnancy. The rate of major malformations in the study group (156 live births) was 3.2%, compared with 4.8% in the control group (187 live births; relative risk, 0.67; 95% confidence interval, 0. 23-1.95). The rate of any pregnancy loss was higher in the exposed group (relative risk, 1.75; 95% confidence interval, 1.47-2.09). Birth weight was lower in the itraconazole group, although that difference may not be clinically significant. Gestational age at birth, rate of preterm delivery, Apgar scores at 1 and 5 minutes, and neonatal complications were comparable between the groups. CONCLUSION Our study supports the hypothesis that the use of itraconazole during pregnancy is safe. Further surveillance and reporting of pregnancy outcomes will help to support this conclusion.
Higher orbital integrals, Shalika germs, and the Hochschild homology of Hecke algebras

We give a detailed calculation of the Hochschild and cyclic homology of the algebra ∞ (G) of locally constant, compactly supported functions on a reductive p-adic group G. We use these calculations to extend to arbitrary elements the definition of the higher orbital integrals introduced by Blanc and Brylinski (1992) for regular semi-simple elements. Then we extend to higher orbital integrals some results of Shalika (1972). We also investigate the effect of the "induction morphism" on Hochschild homology. 2000 Mathematics Subject Classification. 19D55, 46L80, 16E40. 1. Introduction. Orbital integrals play a central role in the harmonic analysis of reductive p-adic groups; they are, for instance, one of the main ingredients in the Arthur-Selberg trace formula. An orbital integral on a unimodular group G is an im- portant particular case of an invariant distribution on G. Invariant distributions have been used in (3) to prove the irreducibility of certain induced representations of GLn over a p-adic field. Let G be a locally compact, totally disconnected topological group. We denote by ∞ (G) the space of compactly supported, locally constant, and complex valued func- tions on G. The choice of a Haar measure on G makes ∞ (G) an algebra with respect to the convolution product. We refer to ∞ (G) with the convolution product as the (full) Hecke algebra of G.I fG is unimodular, then any invariant distribution on G defines a trace on ∞ (G), and conversely, any trace on ∞ (G) is obtained in this way (this well-known fact follows also from Lemma 3.1). Since the space of traces on an algebra A identifies naturally with the first (i.e., 0th) Hochschild cohomology group of that algebra A, it is natural to ask what are all the Hochschild cohomology groups of ∞ (G). The Hochschild cohomology and homology groups of an algebra A are de- noted in this paper by HH q (A) and, respectively, by HHq(A). Since HH q ( ∞ (G)) is the algebraic dual of HHq( ∞ (G)), it is enough to determine the Hochschild homology groups of ∞ (G). In this paper, G is typically a p-adic group, which, we recall, means that G is the set of F-rational points of a linear algebraic group G defined over a finite extension F of the field Qp of p-adic numbers, p being a fixed prime number. The group G does not have to be reductive, although this is certainly the most interesting case. When we assume G (or G, by abuse of language) to be reductive, we state this explicitly. For us, the most important topology to consider on G is the locally compact, totally
Vacuity analysis for property qualification by mutation of checkers

The paper tackles the problem of property qualification focusing in particular on the identification of vacuous properties. It proposes a methodology based on a combination of dynamic and static techniques that, given a set of properties defined to check the correctness of a design implementation, performs vacuity detection. Existing approaches for vacuity checking are as complex as model checking, and they require to define and model check further properties, thus increasing the verification time. Moreover, for some formulae they fail to detect vacuity, as for example in case of tautology. These problems are overcome by our approach. It is based on mutation analysis, thus, it does not require the definition of new properties granting a speed-up of the vacuity analysis process. Moreover, it provides highly accurate vacuity alerts which capture also propositional and temporal tautologies.
Assessing the Impact of Typhoons on Historic Iron Shipwrecks in Chuuk Lagoon Through Changes in the Corrosion Microenvironment

Abstract The corrosion microenvironment of a dozen Second World War iron shipwrecks in Chuuk Lagoon, Federated States of Micronesia, was investigated to see if there were any measurable changes caused by a recent major typhoon. Seven previously inspected wreck sites were used for calibration to assess the environmental impacts. Five new wrecks, including the Fumitzuki, a destroyer of the Imperial Japanese Navy, were assessed at up to twice the depth of previous studies. The new data showed that the logarithm of the corrosion rate falls linearly with depth to 36 m. Measurements of corrosion potentials, concretion thickness and pH showed that many of the vessels suffered partial deconcretion during the typhoon Maysak in April 2015 with concomitant increases in the rate of decay. Regrowth of the colonising marine organisms are presently ameliorating the impact of the typhoon.
From the representation theory of vertex operator algebras to modular tensor categories in conformal field theory.

Two-dimensional conformal quantum field theory (CFT) has inspired an immense amount of mathematics and has interacted with mathematics in very rich ways, in great part through the mathematically dynamic world of string theory. One notable example of this interaction is provided by Verlinde's conjecture: E. Verlinde (1) conjectured that certain matrices formed by numbers called the “fusion rules” in a “rational” CFT are diagonalized by the matrix given by a certain natural action of a fundamental modular transformation (essentially, a certain distinguished element of the group of two-by-two matrices of determinant one with integer entries). His conjecture led him to the “Verlinde formula” for the fusion rules and, more generally, for the dimensions of spaces of “conformal blocks” on Riemann surfaces of arbitrary genera. A great deal of progress has been achieved in interpreting and proving Verlinde's (physical) conjecture and the Verlinde formula in mathematical settings, in the case of the Wess–Zumino–Novikov-Witten models in CFT, which are based on affine Lie algebras. On the other hand, Moore and Seiberg (2, 3) showed, on a physical level of rigor, that the general form of the Verlinde conjecture is a consequence of the axioms for rational CFTs, thereby providing a conceptual understanding of the conjecture. In the process, they formulated a CFT analogue, later termed “modular tensor category” (discussed in refs. 4 and 5) by I. Frenkel, of the classical …
First Attempt to Automatically Generate Hungarian Semantic Verb Classes

Aiming to create verb paraphrases to lay the foundation of sentence paraphrases I automatically created Hungarian semantic verb classes with k-means algorithm. The vector representation of verbs was special: dimensions were cases and values were sets of lemmas that can fill the verb frame position defined by the case. I clustered 900 frequent verbs, from which 243 got into 71 smaller clusters, which tend to be semantically coherent. I evaluated the method intuitively, and verified the good classes by contrasting them with a machine readable synonym dictionary, and also by contrasting them with the new Hungarian WordNet.
lationships between nurses ’ empathy , self-compassion and mensions of professional quality of life : A cross-sectional udy

Background: Job stress and burnout are common among healthcare professionals, and nurses in particular. In addition to the heavy workload and lack of recourses, nurses are also confronted with emotionally intense situations associated with illness and suffering, which require empathic abilities. Although empathy is one of the core values in nursing, if not properly balanced it can also have detrimental consequences, such as compassion fatigue. Self-compassion, on the other hand, has been shown to be a protective factor for a wide range of well-being indicators and has been associated with compassion for others. Objectives: The main goal of this study was to explore how empathy and self-compassion related to professional quality of life (compassion satisfaction, compassion fatigue and burnout). In addition, we wanted to test whether self-compassion may be a protective factor for the impact of empathy on compassion fatigue. Methods and participants: Using a cross-sectional design, 280 registered nurses from public hospitals in Portugal’s north and center region were surveyed. Professional quality of life (Professional Quality of Life), empathy (Interpersonal Reactivity Index) and selfcompassion (Self-compassion Scale) were measured using validated self-report measures. Results: Correlations and regression analyses showed that empathy and self-compassion predicted the three aspects of professional quality of life. Empathic concern was positively associated with compassion satisfaction as well as with compassion fatigue. Mediation models suggested that the negative components of self-compassion explain some of these effects, and self-kindness and common humanity were significant moderators. The same results were found for the association between personal distress and compassion fatigue. Conclusions: High levels of affective empathy may be a risk factor for compassion fatigue, whereas self-compassion might be protective. Teaching self-compassion and self-care skills may be an important feature in interventions that aim to reduce burnout and
Responses of Japanese and American University Students to the STAI Items That Assess the Presence or Absence of Anxiety

Symptom endorsements and item response patterns on the anxiety-present and anxiety-absent items of the State-Trait Anxiety Inventory Form Y (Spielberger, 1983) for 149 Japanese (99 living in Japan and 50 studying in the United States) and 76 American university students were compared. Although mean scores for the state and trait anxiety-absent items were comparable for Japanese students living in Japan and Japanese international students studying in the United States, the scores of both Japanese groups were significantly higher than those of American students. These differences were attributable to much higher scores of Japanese students on anxiety-absent items that corresponded to a lack of positive feelings. Japanese students had a tendency to inhibit positive (anxiety-absent) feelings, resulting in higher anxiety scores. Responses to anxiety-present and anxiety-absent items should be considered independently in scoring anxiety scales.
Temporal Fine-Structure Cues to Speech and Pure Tone Modulation in Observers with Sensorineural Hearing Loss

Objective: The purpose of this study was to examine the effect of sensorineural hearing loss on the ability to make use of fine temporal information and to evaluate the relation between this ability and the ability to recognize speech. Design: Fourteen observers with normal hearing and 12 observers with sensorineural hearing loss were tested on open-set word recognition and on psychophysical tasks thought to reflect use of fine-structure cues: the detection of 2 Hz frequency modulation (FM) and the discrimination of the rate of amplitude modulation (AM) and quasifrequency modulation (QFM). Results: The results showed relatively poor performance for observers with sensorineural hearing loss on both the speech recognition and psychoacoustical tasks. Of particular interest was the finding of significant correlations within the hearing-loss group between speech recognition performance and the psychoacoustical tasks based on frequency modulation, which are thought to reflect the quality of the coding of temporal fine structure. Conclusions: These results suggest that sensorineural hearing loss may be associated with a reduced ability to use fine temporal information that is coded by neural phase-locking to stimulus fine-structure and that this may contribute to poor speech recognition performance and to poor performance on psychoacoustical tasks that depend on temporal fine structure.
Upgrading HTTPS in mid-air: An empirical study of strict transport security and key pinning

We have conducted the first in-depth empirical study of two important new web security features: strict transport security (HSTS) and public-key pinning. Both have been added to the web platform to harden HTTPS, the prevailing standard for secure web browsing. While HSTS is further along, both features still have very limited deployment at a few large websites and a long tail of small, security-conscious sites. We find evidence that many developers do not completely understand these features, with a substantial portion using them in invalid or illogical ways. The majority of sites we observed trying to set an HSTS header did so with basic errors that significantly undermine the security this feature is meant to provide. We also identify several subtle but important new pitfalls in deploying these features in practice. For example, the majority of pinned domains undermined the security benefits by loading non-pinned resources with the ability to hijack the page. A substantial portion of HSTS domains and nearly all pinned domains leaked cookie values, including login cookies, due to the poorly-understood interaction between HTTP cookies and the same-origin policy. Our findings highlight that the web platform, as well as modern web sites, are large and complicated enough to make even conceptually simple security upgrades challenging to deploy in practice.