Miracle-dz/UniFAR-FTUs huggingface dataset:
The Work of Elderly Men Caregivers

Approximately 1,000,000men currently care for spouses with cognitive impairment after leaving market-economy careers through normative or early retirement. In the process, they made the difficult transition from work in the public arena to the private, largely invisible world of family care. This article explores how elderly men caregivers adapt to such drastic changes in social location, what resources they call upon to ameliorate the impact of those changes, and what we can learn from their experiences that will inform future research and practice. Data are from a qualitative study of thirty elderly men care-givers in Rochester, New York. Two major themes emerged, demonstrating both struggle and success. The most significant struggle was coping with the isolation of home care; by contrast, many men were able to successfully make the transition through the use of a style of caregiving that incorporated a combination of management and nurturing skills.
Trivialization of C(X)-algebras with strongly self-absorbing fibres

Suppose $A$ is a separable unital $C(X)$-algebra each fibre of which is isomorphic to the same strongly self-absorbing and $K_{1}$-injective $C^{*}$-algebra $D$. We show that $A$ and $C(X) \otimes D$ are isomorphic as $C(X)$-algebras provided the compact Hausdorff space $X$ is finite-dimensional. This statement is known not to extend to the infinite-dimensional case.
Regulation of cell physiology and pathology by protein S-glutathionylation: lessons learned from the cardiovascular system.

SIGNIFICANCE Reactive oxygen and nitrogen species contributing to homeostatic regulation and the pathogenesis of various cardiovascular diseases, including atherosclerosis, hypertension, endothelial dysfunction, and cardiac hypertrophy, is well established. The ability of oxidant species to mediate such effects is in part dependent on their ability to induce specific modifications on particular amino acids, which alter protein function leading to changes in cell signaling and function. The thiol containing amino acids, methionine and cysteine, are the only oxidized amino acids that undergo reduction by cellular enzymes and are, therefore, prime candidates in regulating physiological signaling. Various reports illustrate the significance of reversible oxidative modifications on cysteine thiols and their importance in modulating cardiovascular function and physiology. RECENT ADVANCES The use of mass spectrometry, novel labeling techniques, and live cell imaging illustrate the emerging importance of reversible thiol modifications in cellular redox signaling and have advanced our analytical abilities. CRITICAL ISSUES Distinguishing redox signaling from oxidative stress remains unclear. S-nitrosylation as a precursor of S-glutathionylation is controversial and needs further clarification. Subcellular distribution of glutathione (GSH) may play an important role in local regulation, and targeted tools need to be developed. Furthermore, cellular redundancies of thiol metabolism complicate analysis and interpretation. FUTURE DIRECTIONS The development of novel pharmacological analogs that specifically target subcellular compartments of GSH to promote or prevent local protein S-glutathionylation as well as the establishment of conditional gene ablation and transgenic animal models are needed.
A 57-GHz CMOS VCO with 185.3% tuning-range enhancement using tunable LC source-degeneration

A 57-GHz CMOS Voltage-Controlled Oscillator (VCO) using tunable LC source-degeneration for operation frequency and tuning-range enhancement is demonstrated. The tunable LC source-degeneration is made by adding two tunable LC tanks, where varactors are used as the needed capacitors, to the source terminals of the cross-coupled transistor pair of the VCO. Compared with the traditional cross-coupled transistor pair, the proposed one significantly decreases the equivalent parallel capacitance (CEQ). This in turn results in the increase of both the operation frequency and the tuning-range of the VCO. The measurement result shows the tunable LC source-degeneration achieved a 185.3% enhancement (from 1.36 GHz (53.36–54.72 GHz) to 3.88 GHz (53.36–57.24 GHz)) in tuning-range by tuning the varactors of the proposed cross-coupled transistor pair.
The herpes simplex virus latency-associated transcript is spliced during the latent phase of infection

The herpes simplex virus type 1 latency-associated transcript (LAT) is expressed as a major species 2,100 to 2,200 bases in length and a less abundant one ca. 730 bases shorter in latently infected mouse and rabbit neurons. RNA blot hybridization experiments using 20- to 22-base synthetic oligonucleotides and mung bean nuclease protection assays have demonstrated that the smaller LAT species is colinear with the larger one, except for a 730-base intron. On the basis of Northern blot analysis, the spliced species which comprises as much as 50% of the total LAT in latent infections of mice with several strains of herpes simplex virus type 1 and latent infections of rabbits with either the McKrae or the KOS(M) strains of virus is not present in the acute phase of infection. Further and rather surprisingly, in mice latently infected with the KOS(M) strain of virus, the spliced LAT species is considerably less abundant. This suggests that both the strain of virus and the animal in which the latent infection occurs are important in either the processing or stability of spliced LAT. Finally, an exhaustive series of experiments failed to provide convincing evidence that a unique, poly(A)+ species of LAT exists in the latent phase of infection.
New Learning Environments for the 21st Century: Exploring the Edge

Even those of us who haven’t been teaching very long don’t have to be told that today’s college students engage with the world differently than we did when we were in school. Today’s students are comfortable satisfying their immense curiosity on their own. This capacity for independent learning is essential to their future well-being, since they are likely to have multiple careers and will need to continually learn new skills they were not taught in college. Our students will need to feel comfortable working in cross-disciplinary teams that encompass multiple ways of knowing. These challenges require that we re-conceptualize parts of our educational system and at the same time find ways to reinforce learning outside of formal schooling. Luckily, successful models of teaching and learning already exist that we could emulate and build on. In the architecture studio, for example, all work in progress is made public. As a consequence, every student can see what every other student is doing; every student witnesses the strategies that others use to develop their designs. And there is public critique, typically by the master and perhaps several outside practitioners. The students not only hear each other’s critiques, but because they were in some sense peripheral participants in the evolution of each other’s work, they also have a moderately nuanced understanding of the design choices and constraints that led to the final result. As a result, the critique has substantial significance for them all—not just for the student whose project is under review. Now compare the efficiency of the professor’s use of time in this situation with that in a typical office hour. Also consider how students in studios start to
The expression of inflammatory cytokines, TAM tyrosine kinase receptors and their ligands is upregulated in venous leg ulcer patients: a novel insight into chronic wound immunity

The systemic host defence mechanisms, especially innate immunity, in venous leg ulcer patients are poorly investigated. The aim of the current study was to measure Candida albicans killing activity and gene expressions of pro‐ and anti‐inflammatory cytokines and innate immune response regulators, TAM receptors and ligands of peripheral blood mononuclear cells separated from 69 venous leg ulcer patients and 42 control probands. Leg ulcer patients were stratified into responder and non‐responder groups on the basis of wound healing properties. No statistical differences were found in Candida killing among controls, responders and non‐responders. Circulating blood mononuclear cells of patients overexpress pro‐inflammatory (IL‐1α, TNFα, CXCL‐8) and anti‐inflammatory (IL‐10) cytokines as well as TAM receptors (Tyro, Axl, MerTK) and their ligands Gas6 and Protein S compared with those of control individuals. IL‐1α is notably overexpressed in venous leg ulcer treatment non‐responders; in contrast, Axl gene expression is robustly stronger among responders. These markers may be considered as candidates for the prediction of treatment response among venous leg ulcer patients.
Interstitial-oxygen-atom diffusion in MgO.

conﬁguration is the ~111! dumbbell centered at a regular oxygen site, whereas face-centered and cube-centered conﬁgurations are higher in energy by 1.45 eV and 3.57 eV, respectively. The~111! conﬁguration isclose in energy to the ~110! conﬁguration, which allows the dumbbell to rotate easily on a lattice site. In allthese four cases the interstitial oxygen atom attracts considerable additional electron density from its nearestregular O
‘I want them to see that I feel normal’: three children’s experiences from attending consultations in paediatric rehabilitation

This article describes and analyses three children’s experiences of taking part in consultations at a paediatric rehabilitation unit in Norway. The analyses focus on how the children express themselves through social life experiences during the consultation. It is discussed how the children apply their embodied knowledge and experience in identifying themselves as normal, and what challenges this identification during a consultation. The analyses emphasize what the children’s experiences can mean, and how these experiences represent professional practice and structural constraints in paediatric rehabilitation. By investigating the child’s embodied knowledge during consultations, a focus on biomedical issues may overshadow the child’s own perceptions of issues related to functioning in everyday life. The children’s descriptions are relevant for advocating children’s participation in matters concerning their own lives, and for disabled children’s participation in decision-making more specifically.
Developmental Aspects of the Renal Response to Hypoxemia in the Lamb Fetus

The effects of fetal hypoxemia on renal hemodynamics and renal function were studied in two groups of chronically catheterized young (<120 days of gestation) and near-term lamb fetuses (>130 days). Fetal hypoxemia produced, in both groups, a significant decrease in renal blood flow (RBF) and a significant increase in the filtration fraction. However, the glomerular filtration rate (GFR) did not change significantly, suggesting that the renal vasoconstriction associated with fetal hypoxemia was more important at the efferent than at the afferent arteriolar level. In the group of near-term fetuses, the decrease in RBF correlated closely with changes in plasma renin activity (PRA) (r = -0.77). No changes in PRA were observed during hypoxemia in the group of young fetuses. After hypoxemia, reactive hyperemia associated with a significant increase in urinary prostaglandin excretion (PGE and PGF2a) was observed in near-term fetuses but not in young fetuses. It also was demonstrated that fetal hypoxemia produced a significant increase in fetal plasma concentrations of vasopressin associated with an antidiuresis in all but one near-term fetus and in 50% of the young fetuses, suggesting that the ability of the fetal kidney to reabsorb free water is more developed in near-term fetuses. Finally, fetal hypoxemia had no effect on mean arterial pressure and heart rate in young fetuses; however, in nearterm fetuses, a significant increase in blood pressure and a decrease in heart rate were observed. In summary, it appears that the response of the fetal kidney to hypoxemia depends on the degree of fetal maturation. Circ Res 48: 128-138. 1981
A Further Examination of the Factors Influencing Current Identification with a Sports Team, a Response to Wann, et al. (1996)

Wann, et al. (1996) have measured factors responsible for identification with American sports teams suggesting that success is the most important factor influencing current identification. This study identifies locality to the team as the most important factor for identification with an English professional football team. Considerable differences suggest that fans from various sporting contexts may have differing reasons for identification with a particular team.
Divergent HIV and Simian Immunodeficiency Virus Surveillance, Zaire

Recent HIV infection or divergent HIV or simian immunodeficiency virus (SIV) strains may be responsible for Western blot–indeterminate results on 70 serum samples from Zairian hospital employees that were reactive in an enzyme immunoassay. Using universal polymerase chain reaction HIV-1, HIV-2, and SIV primers, we detected 1 (1.4%) HIV-1 sequence. Except for 1 sample, no molecular evidence for unusual HIV- or SIV-like strains in this sampling was found.
Tissue expression of four troponin I genes and their molecular interactions with two troponin C isoforms in Caenorhabditis elegans

Gene duplication is a major genetic event that can produce multiple protein isoforms. Comparative sequence and functional analysis of related gene products can provide insights into protein family evolution. To characterize the Caenorhabditis elegans troponin I family, we analyzed gene structures, tissue expression patterns and RNAi phenotypes of four troponin I isoforms. Tissue expression patterns were determined using lacZ/gfp/rfp reporter gene assays. The tni‐1, tni‐2/unc‐27 and tni‐3 genes, each encoding a troponin I isoform, are uniquely expressed in body wall, vulval and anal muscles but at different levels; tni‐4 was expressed solely in the pharynx. Expressing tni‐1 and ‐2 gene RNAi caused motility defects similar to unc‐27 (e155) mutant, a tni‐2 null allele. The tni‐3 RNAi expression produced egg laying defects while the tni‐4 RNAi caused arrest at gastrulation. Overlay analyses were used to assay interactions between the troponin I and two troponin C isoforms. The three body wall troponin I isoforms interacted with body wall and pharyngeal troponin C isoforms; TNI‐4 interacted only with pharyngeal troponin C. Our results suggest the body wall genes have evolved following duplication of the pharynx gene and provide important data about gene duplication and functional differentiation of nematode troponin I isoforms.
NE-10 Neuroendocrine Cancer Promotes the LNCaP Xenograft Growth in Castrated Mice

Increases in neuroendocrine (NE) cells and their secretory products are closely correlated with tumor progression and androgen-independent prostate cancer. However, the mechanisms by which NE cells influence prostate cancer growth and progression, especially after androgen ablation therapy, are poorly understood. To investigate the role of NE cells on prostate cancer growth, LNCaP xenograft tumors were implanted into nude mice. After the LNCaP tumors were established, the NE mouse prostate allograft (NE-10) was implanted on the opposite flank of these nude mice to test whether NE tumor-derived systemic factors can influence LNCaP growth. Mice bearing LNCaP tumors with or without NE allografts were castrated 2 weeks after NE tumor inoculation, and changes in LNCaP tumor growth rate and gene expression were investigated. After castration, LNCaP tumor growth decreased in mice bearing LNCaP tumors alone, and this was accompanied by a loss of nuclear androgen receptor (AR) localization. In contrast, in castrated mice bearing both LNCaP and NE-10 tumors, LNCaP tumors continued to grow, had increased levels of nuclear AR, and secreted prostate-specific antigen. Therefore, in the absence of testicular androgens, NE secretions were sufficient to maintain LNCaP cell growth and androgen-regulated gene expression in vivo. Furthermore, in vitro experiments showed that NE secretions combined with low levels of androgens activated the AR, an effect that was blocked by the antiandrogen bicalutamide. Because an increase in AR level has been reported to be sufficient to account for hormone refractory prostate cancers, the NE cell population ability to increase AR level/activity can be another mechanism that allows prostate cancer to escape androgen ablation therapy.
Rape Causal Attitudes Among Adolescents

Five possible causes of rape—male dominance, female precipitation, society, male sexuality, and male pathology—were compared among high school students from California. Participants (N = 453) completed a group‐administered questionnaire as part of a rape‐education high school outreach provided by two rape crisis centers. Gender, ethnicity, age, and communication sources about rape, including pornography, were related to attitudes about the causes of rape. Within gender, girls rated male pathology the highest of the five causes of rape, and boys rated female precipitation highest. Between genders, girls rated male pathology and male dominance higher and female precipitation lower than did boys. In particular, both female precipitation and male sexuality scores were related to gender, communicating about rape with parents, exposure to pornography, the number of socializing agents with whom girls have discussed rape, girls’ beliefs that they have learned about sex from pornography, and the number of pornogra.
Labor market integration, immigration experience, and psychological distress in a multi-ethnic sample of immigrants residing in Portugal

ABSTRACT Objectives: This study aims at examining how factors relating to immigrants’ experience in the host country affect psychological distress (PD). Specifically, we analyzed the association among socio-economic status (SES), integration in the labor market, specific immigration experience characteristics, and PD in a multi-ethnic sample of immigrant individuals residing in Lisbon, Portugal. Design: Using a sample (n = 1375) consisting of all main immigrant groups residing in Portugal’s metropolitan area of Lisbon, we estimated multivariable linear regression models of PD regressed on selected sets of socio-economic independent variables. A psychological distress scale was constructed based on five items (feeling physically tired, feeling psychologically tired, feeling happy, feeling full of energy, and feeling lonely). Results: Variables associated with a decrease in PD are being a male (demographic), being satisfied with their income level (SES), living with the core family and having higher number of children (social isolation), planning to remain for longer periods of time in Portugal (migration project), and whether respondents considered themselves to be in good health condition (subjective health status). Study variables negatively associated with immigrants’ PD were job insecurity (labor market), and the perception that health professionals were not willing to understand immigrants during a clinical interaction. Conclusion: The study findings emphasized the importance of labor market integration and access to good quality jobs for immigrants’ psychological well-being, as well as the existence of family ties in the host country, intention to reside long term in the host country, and high subjective (physical) health. Our research suggests the need to foster cross-national studies of immigrant populations in order to understand the social mechanisms that transverse all migrant groups and contribute to lower psychological well-being.
CT for the diagnosis of venous thromboembolic disease

Spiral CT, venous ultrasound, ventilation-perfusion scanning, and D-dimer tests are routinely used in the diagnosis of venous thromboembolic disease. Advances in multidetector spiral CT and the combination of CT pulmonary angiography and venography as a one-step evaluation of venous thromboembolic disease have markedly improved detection of subsegmental emboli and deep pelvic venous thrombi and decreased the role of conventional pulmonary angiography. As CT has improved, many have questioned what “gold standard” CT should be compared with. Recent clinical outcome studies suggest that CT results are as good as pulmonary angiography and conventional imaging algorithms. Because the sensitivity of CT pulmonary angiography now exceeds 85%, it also appears that it is also more cost effective than other diagnostic approaches.
A Fast Implementation of Parallel Discrete-Event Simulation on GPGPU

Modern General Purpose Graphics Processing Units(GPGPUs) offer much more computational power than recent CPUs by providing a vast number of simple, data parallel, multithreaded cores. In this study, we focus on the use of a GPGPU to perform parallel discrete-event simulation. Our approach is to use a modified service time distribution function to allow more independent events to be processed in parallel. The implementation issues and alternative strategies will be discussed in detail. We use Thrust, an open-source parallel algorithms library which resembles the C++ Standard Template Library (STL), to build our tool. The experimental results show that our implementation can be more than 60 times faster than the sequential simulation. Furthermore, the speedup curve scales well which indicates that our implementation is suitable for large-scale discreteevent simulation models.
Nanoclustering as a dominant feature of plasma membrane organization

ABSTRACT Early studies have revealed that some mammalian plasma membrane proteins exist in small nanoclusters. The advent of super-resolution microscopy has corroborated and extended this picture, and led to the suggestion that many, if not most, membrane proteins are clustered at the plasma membrane at nanoscale lengths. In this Commentary, we present selected examples of glycosylphosphatidyl-anchored proteins, Ras family members and several immune receptors that provide evidence for nanoclustering. We advocate the view that nanoclustering is an important part of the hierarchical organization of proteins in the plasma membrane. According to this emerging picture, nanoclusters can be organized on the mesoscale to form microdomains that are capable of supporting cell adhesion, pathogen binding and immune cell-cell recognition amongst other functions. Yet, a number of outstanding issues concerning nanoclusters remain open, including the details of their molecular composition, biogenesis, size, stability, function and regulation. Notions about these details are put forth and suggestions are made about nanocluster function and why this general feature of protein nanoclustering appears to be so prevalent.