Miracle-dz/UniFAR-FTUs huggingface dataset:
What’s in a Name? Entity Type Variation across Two Biomedical Subdomains

There are lexical, syntactic, semantic and discourse variations amongst the languages used in various biomedical subdomains. It is important to recognise such differences and understand that biomedical tools that work well on some subdomains may not work as well on others. We report here on the semantic variations that occur in the sublanguages of two biomedical subdomains, i.e. cell biology and pharmacology, at the level of named entity information. By building a classifier using ratios of named entities as features, we show that named entity information can discriminate between documents from each subdomain. More specifically, our classifier can distinguish between documents belonging to each subdomain with an accuracy of 91.1% F-score.
Structure and semantics in OODB class specifications

A class specification contains both structural aspects and semantic aspects. We introduce a mathematically based distinction between structural and semantic aspects. We show how this distinction is used to identify all structural aspects of a class specification to be included in the object type of a class. The model obtained is called the Dual Model due to the separation of structure and semantics in the class specification. Advantages of the separation of structure and semantics have been discussed in previous papers and include separate hierarchies for structural and semantic aspects, refined inheritance mechanisms, support of physical database design and structural integration which is impossible in other models.
The HECT-Type E3 Ubiquitin Ligase AIP2 Inhibits Activation-Induced T-Cell Death by Catalyzing EGR2 Ubiquitination

ABSTRACT E3 ubiquitin ligases, which target specific molecules for proteolytic destruction, have emerged as key regulators of immune functions. Several E3 ubiquitin ligases, including c-Cbl, Cbl-b, GRAIL, Itch, and Nedd4, have been shown to negatively regulate T-cell activation. Here, we report that the HECT-type E3 ligase AIP2 positively regulates T-cell activation. Ectopic expression of AIP2 in mouse primary T cells enhances their proliferation and interleukin-2 production by suppressing the apoptosis of T cells. AIP2 interacts with and promotes ubiquitin-mediated degradation of EGR2, a zinc finger transcription factor that has been found to regulate Fas ligand (FasL) expression during activation-induced T-cell death. Suppression of AIP2 expression by small RNA interference upregulates EGR2, inhibits EGR2 ubiquitination and FasL expression, and enhances the apoptosis of T cells. Therefore, AIP2 regulates activation-induced T-cell death by suppressing EGR2-mediated FasL expression via the ubiquitin pathway.
A general approximated two-dimensional model for piezoelectric array elements

In this paper we describe an approximate two-dimensional model of a single piezoelectric array element. Substantially, the element is a two-dimensional structure whose vibrations can be described by two coupled differential wave equations with coupled boundary conditions. We take as a solution of this system two orthogonal wave functions which depend only on one axis, corresponding to the propagation direction, and which satisfy the boundary conditions only in an integral form. This solution makes it necessary to neglect the piezoelectric coupling in the transverse direction; nevertheless this approximation does not substantially affect the computed results because the transverse elastic coupling is much stronger than the piezoelectric one. With our model, the external behavior of the element in the frequency domain can be described by a 5/spl times/5 matrix from which all the transfer functions of the element can be easily computed. We compared our results with those of the classical Mason-Sittig one dimensional model, finding, as expected, a small difference in the principal thickness resonance frequency and the presence of a lateral mode. To verify the results obtained with our model, we computed the frequency spectrum of the element varying the width/thickness ratio. We found a good agreement with the low branch of the spectrum computed by the coupled mode theory. Finally, we computed, in the frequency domain, the dynamic electromechanical coupling coefficient k/sub U/, evaluating the internal energy distribution of the element and applying the definition reported by Berlincourt. We compared the values at resonance with the appropriate quasistatic coupling factors k/sub 33/' and k/sub 31/' and with the effective coupling factor k/sub eff/ computed by the same model. <<ETX>>
Effects of maternal HIV on children's psychosocial adjustment with peers and with their mother

A longitudinal assessment of young adolescents' psychosocial outcomes affected by maternal HIV/AIDS was undertaken, focusing on both parent–child psychosocial ties and peer relationships. Data were taken from the Parents and Children Coping Together (PACT) study, a 15-year study assessing mothers with HIV/AIDS and their well children every six months. Families (N = 118) who participated in PACT II and PACT III are included in the current analyses, who were assessed every six months for 36 months in PACT II, and every six months for 18 months in PACT III (providing 11 time points of data across eight years). Growth curve modeling was applied to assess the associations of maternal health on adolescent's psychosocial outcomes. In terms of their relationship with their mothers living with HIV (MLH), adolescents' psychosocial functioning was negatively impacted by maternal illness, specifically viral load count and vitality levels, whereas several indicators of increased maternal illness (including viral load, vitality, illness symptoms, and health-related anxiety) predicted less attachment with peers. In addition, MLH increased illness was associated with more adolescent autonomy.
Disconnection of intracortical synaptic linkages disrupts synchronization of a slow oscillation

The intracortical synaptic linkages underlying the synchronization of a recently described slow (< 1 Hz) oscillation (Steriade et al., 1993b,c) were investigated in anesthetized cats by means of multisite extra- and intracellular recordings, including dual impalements, from rostral and caudal sites in the association cortical suprasylvian and marginal gyri, before and after reversible lidocaine inactivation or transections in the middle suprasylvian gyrus. Stimulus-evoked responses revealed that the rostral and caudal suprasylvian foci are reciprocally connected, with a preference for posterior-to-anterior responses. Lidocaine infusion between the stimulating and recording sites disrupted the intracortical synaptic linkage, while leaving unaffected the responses at the sites close to the stimulating electrodes. The high coherence between slowly oscillating field potentials and intracellular activities recorded from anterior and posterior suprasylvian foci was lost after reversible inactivation or transections in the middle suprasylvian gyrus, whereas the synchrony between adjacent foci within the anterior or posterior areas was preserved. Two to four hours after inactivation or transection the synchrony between all channels was totally or partially recovered. We introduced the synchrony coefficient (SyCo) and calculated the SyCo for closely located and distant sites. Lidocaine infusion or transection did not affect the SyCo between leads placed on the same site, but significantly (60%) decreased the SyCo between channels separated by the functionally inactivated or transected sector. Our results demonstrate that pathways within or beneath the suprasylvian gyrus sustain the synchronization of the slow oscillation between cortical sites. As the loss of long-range coherence was not permanent, intergyral paths and/or corticothalamocortical loops may exert compensatory functions after the disconnection of intrasuprasylvian synaptic linkages.
Treatment of recurrent periodontal disease by root planing and Ornidazole (Tiberal). Clinical and microbiological findings.

The purpose of this study was to evaluate the use of Ornidazole as an adjunct to root planing in the therapy of patients suffering from recurrent periodontal disease. In 10 individuals who had previously been treated with scaling, root planing and periodontal surgery and who had followed a regular maintenance program including recall visits every 3-5 months for 1-7 years, 2 sites with recurrent periodontitis and 1 shallow site were selected. Reinfected sites had a record of losing clinical attachment of more than 3 mm since the completion of initial therapy, were bleeding upon probing and had a mean pocket probing depth of 7.85 +/- 1.31 mm. They had been reinstrumented several times by a registered dental hygienist, when clinical signs of recurrence of disease had appeared and the root surfaces were judged to be smooth and free of deposits. Clinical parameters were recorded and microbial samples were collected twice prior to retreatment. Then, 500 mg Ornidazole, to be taken twice a day for 10 days, was administered, and the whole dentition was thoroughly scaled and root planed. At day 10 as well as 2, 5, 8 and 11 months thereafter, samples were again obtained. At baseline, reinfected sites showed over 20% spirochetes, over 20% motile rods and over 9% fusiform organisms in darkfield preparations of subgingival plaque samples. Culturally, over 1/10 of organisms were identified as black pigmenting Bacteroides and in 18% of all baseline samples collected, B. gingivalis was found. (ABSTRACT TRUNCATED AT 250 WORDS)
Educators' Experience of Teaching Nursing Research to Undergraduates

Most research pertaining to the teaching of nursing research has focused on learning outcomes and students' attitudes toward research. Few scholars have explored what it is like to teach nursing research. The purpose of this study was to describe the experience of teaching undergraduate nursing research. Data were obtained from 12 nurse educators through e-mail interviews and analyzed using Giorgi's method of descriptive phenomenology. Four meaning units describe the experience: marketing research content, introducing the research process, enhancing student abilities to learn about research, and enhancing personal abilities to teach research. The three meaning units that focus on faculty intentions toward students are somewhat consistent with prior research but include interesting new ideas. Concerning the last meaning unit, participants reported an interest in learning about teaching strategies, advanced statistics, and informational technology. Deans and directors should explore the learning needs of such faculty and offer appropriate ongoing education.
Geographical Distribution of Thundersnow Events and Their Properties From GPM Ku‐Band Radar

Six‐years (2010–2015) of snow lightning characteristics and climatology, including seasonal, diurnal, and surface temperature distribution, are generated. The World Wide Lightning Location Network (WWLLN) and the National Lightning Detection Network lightning observations are collocated with Modern‐Era Retrospective Analysis for Research and Application (MERRA‐2) temperatures. Cold season lightning events are identified as lightning with the MERRA‐2 two‐meter surface temperature colder than 0 °C and then further classified as snow lightning or thundersnow, when the entire vertical temperature profile is below 2 °C, and as freezing rain lightning when there is a temperature warmer than 2 °C somewhere in the column above the freezing surface. The statistics of snow lightning events from WWLLN and National Lightning Detection Network are well matched and are consistent with the climatology of thundersnow days reported at ground‐based stations over the United States. Using 4 years of observations from the Global Precipitation Measuring Mission Ku band radar, 443 Thunder Snow Features (TSFs) are defined, having a contiguous area of nonzero near surface snow precipitation derived from the Ku band radar and MERRA‐2 data, along with collocated WWLLN lightning flashes. The majority (about 394) are found over high mountainous regions such the Himalayas, Tibet, the Andes, and the Zagros mountain regions. Low‐elevation TSFs (45) are observed over the continental and coastal regions. Though only a small number of TSFs are identified with 4 years of Global Precipitation Mission data, most TSFs have maximum radar reflectivity above 30 dBZ at temperature colder than −10 °C, which indicates the importance of the noninductive charging process in these events.
Degradation Mechanisms in CMOS Power Amplifiers Subject to Radio-Frequency Stress and Comparison to the DC Case

An in-depth study of the degradation dynamics in CMOS power amplifiers is presented. The transistor was operated at 1.9 GHz under real-world load and power conditions. Threshold voltage and sub-threshold slope were monitored as a measure of the device degradation versus stress time. Experimental evidence is provided, which demonstrates that damage severity strongly depends on the features of drain voltage and current waveforms, rather than on average dissipated power. The results of RF stress tests are compared to dc hot carrier and Fowler-Nordheim experiments. Large discrepancies are found between measurements and the quasi-static model.
Gender-specific Mental Health Care Needs of Women Veterans Treated for Psychiatric Disorders in a Veterans Administration Women’s Health Clinic

Objective:This pilot study aims to ascertain the prevalence of self-reported premenstrual, perinatal, and perimenopausal influences on mental health, and of gynecologic conditions that could interact with psychiatric conditions, among women veterans receiving psychiatric care within a Veterans Administration (VA) Women’s Health Clinic (WHC). Methods:Participants included all women veterans (N=68) who received psychiatric evaluations within a VA WHC over a 5-month period. This setting encompasses colocated and coordinated primary care, gynecologic and mental health services. Evaluations included a Women’s Mental Health Questionnaire, a psychiatric interview, and medical record review. Deidentified data were extracted from a clinical data repository for this descriptive study. Results:High proportions of study participants reported that their emotional problems intensified premenstrually (42.6%), during pregnancy (33.3%), in the postpartum period (33.3%), or during perimenopause (18.2%). Unintended pregnancy (70.0% of pregnancies) and pregnancy loss (63.5% of women who had been pregnant) were prominent sex-linked stressors. Dyspareunia (22.1% of participants) and pelvic pain (17.6% of participants) were frequent comorbidities. Conclusions:Among women veterans receiving psychiatric care within a VA WHC, there are high rates of self-reported premenstrual, perinatal, and perimenopausal influences on mental health. This population also has substantial comorbidity of psychiatric disorders with dyspareunia and pelvic pain. This underscores the importance of recognizing and addressing women veterans’ sex-specific care needs, including interactions among reproductive cycle phases, gynecologic pain, and psychiatric symptoms. The findings support the need for greater awareness of the sex-specific mental health needs of women veterans, and for more definitive studies to further characterize these needs.
Plate load test of base taken from coal ash and slag mixture in experimental tray and on experimental section of embankment

The soil study in experimental trays has a number of advantages in comparison with field experiments. It is easier to create the required conditions in the laboratory, it is possible to exclude the superfluous factors influence on the experiment course. However, in a reinforced concrete tray of insufficient size, a special stressed state is created, which influence on the test results is to be taken into account additionally. The paper discusses the results of two experimental studies on the ash and slag mixture (ASM) modulus of elasticity determination: one was carried out in the experimental section of base from the ash and slag mixture; the second - in the experimental tray filled with the same ash and slag mixture. Both experiments were carried out using the same method of stamp test at the same moisture content and the compaction coefficient of the ASM. Based on the test results, the analysis of deformation parameters, determined in different conditions, is carried out. The dependences of the change in the modulus of elasticity on the moistening degree of the ASM are analyzed.
Hermite functions and uncertainty principles for the Fourier and the windowed Fourier transforms

We extend an uncertainty principle due to Beurling into a characterization of Hermite functions. More precisely, all functions f on Rd which may be written as P(x)exp(-(Ax,x)), with A a real symmetric definite positive matrix, are characterized by integrability conditions on the product f(x)f(y). We then obtain similar results for the windowed Fourier transform (also known, up to elementary changes of functions, as the radar ambiguity function or the Wigner transform). We complete the paper with a sharp version of Heisenberg's inequality for this transform.
First Detection of Heartland Virus (Bunyaviridae: Phlebovirus) from Field Collected Arthropods

Heartland virus (HRTV), the first pathogenic Phlebovirus (Family: Bunyaviridae) discovered in the United States, was recently described from two Missouri farmers. In 2012, we collected 56,428 ticks representing three species at 12 sites including both patients' farms. Amblyomma americanum and Dermacentor variabilis accounted for nearly all ticks collected. Ten pools composed of deplete nymphs of A. americanum collected at a patient farm and a nearby conservation area were reverse transcription-polymerase chain reaction positive, and eight pools yielded viable viruses. Sequence data from the nonstructural protein of the Small segment indicates that tick strains and human strains are very similar, ≥ 97.6% sequence identity. This is the first study to isolate HRTV from field-collected arthropods and to implicate ticks as potential vectors. Amblyomma americanum likely becomes infected by feeding on viremic hosts during the larval stage, and transmission to humans occurs during the spring and early summer when nymphs are abundant and actively host seeking.
Emotion-Related Self-Regulation in Children

In this article, the authors review basic conceptual issues in research on children’s emotion-related self-regulation, including the differentiation between self-regulation that is effortful and voluntary and control-related processes that are less amenable to effortful control. In addition, the authors summarize what researchers know about developmental changes in self-regulatory capacities, give examples of various methods used to assess these abilities, and summarize findings on the relations between self-regulation or effortful control and positive adjustment and maladjustment. Finally, the authors discuss some strategies for effectively teaching students about emotion regulation.
Transcriptional repression of ANGPT1 by histone H3K9 demethylase KDM3B

Here we report that the H3K9 demethylase KDM3B represses transcription of the angiogenesis regulatory gene, ANGPT1. Negative regulation of ANGPT1 by KDM3B is independent of its Jumonji (JmjC) domain-mediated H3K9 demethylase activity. We demonstrate that KDM3B downregulates ANGPT1 via interaction with SMRT, and suggest that the repressor complex is formed at the promoter area of ANGPT1. Using MTT and wound healing assays, depletion of KDM3B was found to increase cell proliferation and cell motility, indicating that KDM3B has a role in angiogenesis. [BMB Reports 2015; 48(7): 401-406]
Cerebral autoregulation in carotid artery occlusive disease assessed from spontaneous blood pressure fluctuations by the correlation coefficient index.

BACKGROUND AND PURPOSE Estimation of dynamic cerebral autoregulation from spontaneous fluctuations of arterial blood pressure (ABP) and cerebral blood flow velocity (CBFV) is an attractive monitoring option for cerebral hemodynamic impairment. We evaluated the correlation coefficient index method in patients with severe obstructive carotid disease and compared it with transfer function analysis (frequency domain approach to cerebral autoregulation) and CO2 vasomotor reactivity. METHODS In 139 patients with severe unilateral carotid stenosis (>or=70%) or occlusion, CBFV (transcranial Doppler) and ABP (Finapres method) were recorded over 10 minutes. Correlations between systolic pressure, diastolic pressure, and mean ABP and CBFV oscillations over 1-minute epochs were averaged over 10 minutes to form the correlation coefficient indexes (Sx, Dx, Mx, respectively). Transfer function parameters (phase shift and gain between ABP and CBFV oscillations) were determined from the entire 10-minute period. CO2 reactivity was assessed by inhalation of 7% CO2. RESULTS The correlation indexes Dx and Mx were significantly higher ipsilateral to stenosis and increased with degree of stenosis, indicating increasing dependence of CBFV on ABP and thus impairment of cerebral autoregulation. Dx and Mx correlated moderately but highly significantly with transfer function parameters and CO2 reactivity and showed a good level of agreement in detecting pathological values. Patients with a small variance of the 1-minute source correlations of Dx and Mx showed clearly better correlation values. Transfer function parameters and CO2 reactivity but not Dx and Mx were significantly poorer in patients with symptomatic stenosis or occlusion. CONCLUSIONS The potential of the correlation coefficient indexes Dx and Mx in detecting hemodynamic impairment in patients with carotid stenosis is comparable to that of transfer function analysis and CO2 reactivity testing. In future, a combination of various hemodynamic tests might help to identify patients at risk for ischemic events.
CRISP-DM: Towards a Standard Process Model for Data Mining

The CRISP-DM (CRoss Industry Standard Process for Data Mining) project proposed a comprehensive process model for carrying out data mining projects. The process model is independent of both the industry sector and the technology used. In this paper we argue in favor of a standard process model for data mining and report some experiences with the CRISP-DM process model in practice. We applied and tested the CRISP-DM methodology in a response modeling application project. The final goal of the project was to specify a process which can be reliably and efficiently repeated by different people and adapted to different situations. The initial projects were performed by experienced data mining people; future projects are to be performed by people with lower technical skills and with very little time to experiment with different approaches. It turned out, that the CRISP-DM methodology with its distinction of generic and specialized process models provides both the structure and the flexibility necessary to suit the needs of both groups. The generic CRISP-DM process model is useful for planning, communication within and outside the project team, and documentation. The generic check-lists are helpful even for experienced people. The generic process model provides an excellent foundation for developing a specialized process model which prescribes the steps to be taken in detail and which gives practical advice for all these steps.