Miracle-dz/UniFAR-FTUs huggingface dataset:
Making Schools Smarter: Leading With Evidence

Preface Acknowledgments About the Authors 1. Introduction Part I. Basic Assumptions About Schools and Districts 2. Clarifying Assumptions: Three Perspectives 3. What Is a Professional Learning Community? Part II. Educational Inputs and Outcomes 4. What Are Schools Given to Work With? 5. What Ought to Be Accomplished? Part III. Critical Processes and Conditions: A Systems Orientation to the Core Technology of Schooling 6. Leadership and Management 7. Mission and Goals, Culture and Community 8. Planning and Instructional Services 9. Structure and Organization, and Data-Driven Decision Making 10. Policies and Procedures, and Community Partnerships Part IV. Gathering and Using School and District Monitoring Information 11. Collecting, Analyzing, and Interpreting Monitoring Information 12. Using School and District Monitoring Information Appendix A: The School Surveys Appendix B: The District Surveys References Index
Video-based Human Activity Analysis : An Operator-based Approach

Human activity in video sequences may be viewed as a sampled trajectory on a low dimensional manifold embedded in a high dimensional ambient space. Due to the unknown underlying manifold structure of the image frames, we propose a novel framework to define a neighborhood for high dimensional data which, when acted upon by a mapping operator, results in a subset in an a priorily well defined range space. We exploit the so-called correlation filtering with a specifically selected output response to effectively approximate the data manifold by way of encoding local neighborhoods on it. This helps us propose an unsupervised learning algorithm of human activity, and demonstrate its performance in classifying and clustering of different activities taking place in observed video sequences.
Survey and Evaluation of Audio Fingerprinting Schemes for Mobile Query-by-Example Applications

We survey and evaluate popular audio fingerprinting schemes in a common framework with short query probes captured from cell phones. We report and discuss results important for mobile applications: Receiver Operating Characteristic (ROC) performance, size of fingerprints generated compared to size of audio probe, and transmission delay if the fingerprint data were to be transmitted over a wireless link. We hope that the evaluation in this work will guide work towards reducing latency in practical mobile audio retrieval applications.
Virus Host Protein Interaction Network Analysis Reveals That the HEV ORF3 Protein May Interrupt the Blood Coagulation Process

Hepatitis E virus (HEV) is endemic worldwide and a major cause of acute liver disease in developing countries. However, the molecular mechanisms of liver pathology and clinical disease are not well understood for HEV infection. Open reading frame 3 (ORF3) of HEV encodes a small phosphoprotein, which is assumed to be involved in liver pathology and clinical disease. In this study, the interactions between the HEV ORF3 protein and human proteins were investigated using a stringent, high-throughput yeast two-hybrid (Y2H) analysis. Thirty two proteins were shown to interact with genotype 1 ORF3, 28 of which have not been reported previously. These novel interactions were evaluated by coimmunoprecipitation of protein complexes from transfected cells. We found also that the ORF3 proteins of genotype 4 and rabbit HEV interacted with all of the human proteins identified by the genotype 1 ORF3 protein. However, the putative ORF3 protein derived from avian HEV did not interact with the majority of these human proteins. The identified proteins were used to infer an overall interaction map linking the ORF3 protein with components of the host cellular networks. Analysis of this interaction map, based on functional annotation with the Gene Ontology features and KEGG pathways, revealed an enrichment of host proteins involved in complement coagulation, cellular iron ion homeostasis and oxidative stress. Additional canonical pathway analysis highlighted the enriched biological pathways relevant to blood coagulation and hemostasis. Consideration of the clinical manifestations of hepatitis E reported previously and the results of biological analysis from this study suggests that the ORF3 protein is likely to lead to an imbalance of coagulation and fibrinolysis by interacting with host proteins and triggering the corresponding pathological processes. These results suggest critical approaches to further study of the pathogenesis of the HEV ORF3 protein.
Kent Academic Repository Versions of Research Enquiries Citation for Published Version Link to Record in Kar Document Version the Control of Attention to Faces

If you believe this document infringes copyright then please contact the KAR admin team with the take-down information provided at http://kar.kent. ac.uk/contact.html Citation for published version Bindemann, Markus and Burton, A. Mike and Langton, Stephen R. H. and Schweinberger, Stefan R. and Doherty, Martin J. (2007) The control of attention to faces. Journal of Vision, 7 (10:15). pp. 1-8. ISSN 1534-7362 .
Minimum Wage Increases Under Straightened Circumstances

Do apparently large minimum wage increases in an environment of recession produce clearer evidence of disemployment effects than is typically observed in the new minimum wage literature? This paper augments the sparse literature on the most recent increases in the U.S. minimum wage, using three different data sets and the two main estimation strategies for handling geographically-disparate trends. The evidence is generally unsupportive of negative employment effects, still less of a 'recessionary multiplier. ' Minimum wage workers seem to be concentrated in sectors of the economy for which the labor demand response to wage mandates is minimal.
Correlation Analysis between Airfoil Icing and Icing Cloud Conditions Based on PLS Methods

Ice shape feature parameters include iced area, icing mass, lower horn angle, upper horn angle, lower icing limit, upper icing limit, lower horn thickness and upper horn thickness, etc. Using the Partial Least Square (PLS) method, regression models for the first four parameters are established, where the first two are presented in this paper and the other two are not due to the limitation of space; while models for the other four ice features parameters are not established successfully and some reasons are given. Variation trends of the first two parameters predicted by PLS regression models built are compared with those obtained byMiller. It shows the two agree quite well. Air Temperature (T) and Liquid Water Content (LWC) has the most effects on iced area. Median Volume Diameter (MVD), T and Freezing Fraction (h ) has the most effects on icing mass. Other icing cloud condition parameters have little effects on them.
Cerebellum in Levodopa-Induced Dyskinesias: The Unusual Suspect in the Motor Network

The exact mechanisms that generate levodopa-induced dyskinesias (LID) during chronic levodopa therapy for Parkinson’s disease (PD) are not yet fully established. The most widely accepted theories incriminate the non-physiological synthesis, release and reuptake of dopamine generated by exogenously administered levodopa in the striatum, and the aberrant plasticity in the cortico-striatal loops. However, normal motor performance requires the correct recruitment of motor maps. This depends on a high level of synergy within the primary motor cortex (M1) as well as between M1 and other cortical and subcortical areas, for which dopamine is necessary. The plastic mechanisms within M1, which are crucial for the maintenance of this synergy, are disrupted both during “OFF” and dyskinetic states in PD. When tested without levodopa, dyskinetic patients show loss of treatment benefits on long-term potentiation and long-term depression-like plasticity of the intracortical circuits. When tested with the regular pulsatile levodopa doses, they show further impairment of the M1 plasticity, such as inability to depotentiate an already facilitated synapse and paradoxical facilitation in response to afferent input aimed at synaptic inhibition. Dyskinetic patients have also severe impairment of the associative, sensorimotor plasticity of M1 attributed to deficient cerebellar modulation of sensory afferents to M1. Here, we review the anatomical and functional studies, including the recently described bidirectional connections between the cerebellum and the basal ganglia that support a key role of the cerebellum in the generation of LID. This model stipulates that aberrant neuronal synchrony in PD with LID may propagate from the subthalamic nucleus to the cerebellum and “lock” the cerebellar cortex in a hyperactive state. This could affect critical cerebellar functions such as the dynamic and discrete modulation of M1 plasticity and the matching of motor commands with sensory information from the environment during motor performance. We propose that in dyskinesias, M1 neurons have lost the ability to depotentiate an activated synapse when exposed to acute pulsatile, non-physiological, dopaminergic surges and become abnormally receptive to unfiltered, aberrant, and non-salient afferent inputs from the environment. The motor program selection in response to such non-salient and behaviorally irrelevant afferent inputs would be abnormal and involuntary. The motor responses are worsened by the lack of normal subcortico–cortical inputs from cerebellum and basal ganglia, because of the aberrant plasticity at their own synapses. Artificial cerebellar stimulation might help re-establish the cerebellar and basal ganglia control over the non-salient inputs to the motor areas during synaptic dopaminergic surges.
Physical Activity Improves Verbal and Spatial Memory in Older Adults with Probable Mild Cognitive Impairment: A 6-Month Randomized Controlled Trial

We report secondary findings from a randomized controlled trial on the effects of exercise on memory in older adults with probable MCI. We randomized 86 women aged 70–80 years with subjective memory complaints into one of three groups: resistance training, aerobic training, or balance and tone (control). All participants exercised twice per week for six months. We measured verbal memory and learning using the Rey Auditory Verbal Learning Test (RAVLT) and spatial memory using a computerized test, before and after trial completion. We found that the aerobic training group remembered significantly more items in the loss after interference condition of the RAVLT compared with the control group after six months of training. In addition, both experimental groups showed improved spatial memory performance in the most difficult condition where they were required to memorize the spatial location of three items, compared with the control group. Lastly, we found a significant correlation between spatial memory performance and overall physical capacity after intervention in the aerobic training group. Taken together, our results provide support for the prevailing notion that exercise can positively impact cognitive functioning and may represent an effective strategy to improve memory in those who have begun to experience cognitive decline.
HPV E6/E7 mRNA Testing Is More Specific than Cytology in Post-Colposcopy Follow-Up of Women with Negative Cervical Biopsy

Background In Norway, women with negative or low-grade cervical biopsies (normal/CIN1) are followed up after six months in order to decide on further follow-up or recall for screening at three-year intervals. A high specificity and positive predictive value (PPV) of the triage test is important to avoid unnecessary diagnostic and therapeutic procedures whereas a low risk of high-grade disease among triage negative women assures safety. Materials and Methods At the University Hospital of North Norway, cytology and the HPV mRNA test PreTect HPV-Proofer, detecting E6/E7 mRNA from HPV types 16, 18, 31, 33 and 45, are used in post-colposcopy follow-up of women with negative or low-grade biopsy. In this study, women with negative biopsy after high grade cytology (ASC-H/HSIL) and/or positive HPV mRNA test in the period 2005–2009 were included (n = 520). Histologically confirmed cervical intraepithelial neoplasia of grade 2 or worse (CIN2+) was used as study endpoint. Results Of 520 women with negative or low-grade biopsy, 124 women (23.8%) had CIN2+ in follow-up biopsy. The sensitivity and specificity of the HPV mRNA test were 89.1% (95% CI, 80.1–98.1) and 92.5% (95% CI, 88.2–96.7), respectively. The ratios of sensitivity, specificity and PPV of HPV mRNA testing compared to repeat cytology for finding CIN2+ was 1.05 (95% CI: 0.92–1.21), 1.21 (95% CI: 1.12–1.32), and 1.49 (95% CI: 1.20–1.86), respectively. The PPV of mRNA was 77.3% (95% CI, 59.8–94.8) in women aged 40 or older. Conclusion Women with negative cervical biopsy require follow-up before resumption of routine screening. Post-colposcopy HPV mRNA testing was as sensitive but more specific than post-colposcopy cytology. In addition, the HPV mRNA test showed higher PPV. A positive mRNA test post-colposcopy could justify treatment in women above 40 years.
Chemical Models of Collapsing Envelopes

We discuss recent models of chemical evolution in the developing and collapsing protostellar envelopes associated with low-mass star formation. In particular, the effects of depletion of gas-phase molecules onto grain surfaces is considered. We show that during the middle to late evolutionary stages, prior to the formation of a protostar, various species selectively deplete from the gas phase. The principal pattern of selective depletions is the depletion of sulfur-bearing molecules relative to nitrogen-bearing species: NH3 and N2H+. This pattern is shown to be insensitive to the details of the dynamics and marginally sensitive to whether the grain mantle is dominated by polar or non-polar molecules. Based on these results we suggest that molecular ions are good tracers of collapsing envelopes. The effects of coupling chemistry and dynamics on the resulting physical evolution are also examined. Particular attention is paid to comparisons between models and observations.
Identification and Expression of Two Novel Cytochrome P450 Genes, CYP6CV1 and CYP9A38, in Cnaphalocrocis medinalis (Lepidoptera: Pyralidae)

ABSTRACT. Cnaphalocrocis medinalis Güenée can cause severe losses in rice. Cytochrome P450s play crucial roles in the metabolism of allelochemicals in herbivorous insects. Two novel P450 cDNAs, CYP6CV1 and CYP9A38, were cloned from the midgut of C. medinalis. CYP6CV1 encodes a protein of 500 amino acid residues, while CYP9A38-predicted protein has 531 amino acid residues. Both cDNApredicted proteins contain the conserved functional domains for all P450s. Phylogenetic analyses showed that CYP6CV1 is grouped in the cluster containing CYP6B members, while CYP9A38 is in the cluster including CYP9 members. However, both clusters are contained in the same higher lineage. Homologous analysis revealed that CYP6CV1 is most similar to CYP6B8, CYP6B7, CYP6B6, CYP6B2, and CYP6B4 with the highest amino acid identity of 41%. CYP9A38 is closest to CYP9A17, CYP9A21, CYP9A20, and CYP9A19 with the highest amino acid identity of 66%. Studies of temporal expression profiles revealed that CYP9A38 showed a steady increase in mRNA level during the five instar stages, but a low-expression level in pupae, and then presented at a high-expression level again in adults. Similar expression patterns were obtained with CYP6CV1. In the fifth instar larvae, CYP6CV1 was mainly expressed in midgut and fat bodies, whereas CYP9A38 was mainly expressed in midgut. Expression studies also revealed a 3.20-fold over-expression of CYP6CV1 and 3.54-fold over-expression of CYP9A38 after larval exposure to host rice resistance. Our results suggest that both CYP6CV1 and CYP9A38 may be involved in detoxification of rice phytochemicals.
Effective treatment of ductal carcinoma in situ with a HER-2-targeted alpha-particle emitting radionuclide in a preclinical model of human breast cancer

The standard treatment for ductal carcinoma in situ (DCIS) of the breast is surgical resection, followed by radiation. Here, we tested localized therapy of DCIS in mice using the immunoconjugate 225Ac linked-trastuzumab delivered through the intraductal (i.duc) route. Trastuzumab targets HER-2/neu, while the alpha-emitter 225Ac (half-life, 10 days) delivers highly cytotoxic, focused doses of radiation to tumors. Systemic 225Ac, however, elicits hematologic toxicity and at high doses free 213Bi, generated by its decay, causes renal toxicity. I.duc delivery of the radioimmunoconjugate could bypass its systemic toxicity. Bioluminescent imaging showed that the therapeutic efficacy of intraductal 225Ac-trastuzumab (10-40 nCi per mammary gland; 30-120 nCi per mouse) in a DCIS model of human SUM225 cancer cells in NSG mice was significantly higher (p<0.0003) than intravenous (120 nCi per mouse) administration, with no kidney toxicity or loss of body weight. Our findings suggest that i.duc radioimmunotherapy using 225Ac-trastuzumab deserves greater attention for future clinical development as a treatment modality for early breast cancer.
Effect of Intermittent Hypoxia and Rimonabant on Glucose Metabolism in Rats: Involvement of Expression of GLUT4 in Skeletal Muscle

Background Obstructive sleep apnea (OSA) and its main feature, chronic intermittent hypoxia (IH) during sleep, is closely associated with insulin resistance (IR) and diabetes. Rimonabant can regulate glucose metabolism and improve IR. The present study aimed to assess the effect of IH and rimonabant on glucose metabolism and insulin sensitivity, and to explore the possible mechanisms. Material/Methods Thirty-two rats were randomly assigned into 4 groups: Control group, subjected to intermittent air only; IH group, subjected to IH only; IH+NS group, subjected to IH and treated with normal saline; and IH+Rim group, subjected to IH and treated with 10 mg/kg/day of rimonabant. All rats were killed after 28 days of exposure. Then, the blood and skeletal muscle were collected. We measured fasting blood glucose levels, fasting blood insulin levels, and the expression of glucose transporter 4 (GLUT4) in both mRNA and protein levels in skeletal muscle. Results IH can slow weight gain, increase serum insulin level, and reduce insulin sensitivity in rats. The expressions of GLUT4 mRNA, total GLUT4, and plasma membrane protein of GLUT4 (PM GLUT4) in skeletal muscle were decreased. Rimonabant treatment was demonstrated to improve weight gain and insulin sensitivity of the rats induced by IH. Rimonabant significantly upregulated the expression of GLUT4 mRNA, PM GLUT4, and total GLUT4 in skeletal muscle. Conclusions The present study demonstrates that IH can cause IR and reduced expression of GLUT4 in both mRNA and protein levels in skeletal muscle of rats. Rimonabant treatment can improve IH – induced IR, and the upregulation of GLUT4 expression may be involved in this process.
Familial aggregation of primary open angle glaucoma in Shanghai, China

Purpose To identify familial aggregation of primary open angle glaucoma (POAG) in first-degree relatives in Shanghai, China. Methods This was a prospective case-control study. First-degree relatives of 113 POAG patients and 119 normal controls underwent a standardized ophthalmic examination. Each participant was diagnosed as normal, glaucoma suspect or glaucoma. The prevalence of glaucoma and glaucoma suspect in each group was calculated, and the odds ratio (OR) and 95% confidence interval (CI) for family history were estimated using the Generalized Estimating Equations model. Results Of 531 first-degree relatives in the case group, 67 (12.62%) were identified to have POAG, a rate eight times higher than that of the control group (8 of 526, 1.52%). In family units, the prevalence OR value of glaucoma was 8.77 (95% CI: 3.73–20.62). The effect of family history on parents, siblings, and offspring of probands was statistically significant, with OR values of 6.92 (95% CI: 1.90–25.18), 11.29 (95% CI: 3.63–35.11), and 11.35 (95% CI: 1.69–76.21), respectively. In the case of glaucoma suspect, a significant effect was found for both family units (OR 5.60; 95% CI: 1.15–27.21) and offspring (10.83 OR; 95% CI: 1.34–87.73). Conclusions In Shanghai, relatives of glaucoma patients have a strongly increased risk of glaucoma, and priorities for glaucoma screening should target this population. The study demonstrates that familial aggregation of POAG transcends racial and cultural boundaries.
Volatile FPGA design security { a survey

Volatile FPGAs, the dominant type of programmable logic devices, are used in space, military, automotive, and consumer electronics applications which require them to operate in a wide range of environments. The continuous growth in both their capability and capacity now requires signicant resources to be invested in the designs that are created for them. This has brought increased interest in the security attributes of FPGAs; specically, how well do they protect the information processed within it, how are designs protected during distribution, and how developers’ ownership rights are protected while designs from multiple sources are combined. This survey establishes the foundations for discussing \FPGA security", examines a wide range of attacks and defenses along with the current state of industry oerings, and nally, outlines on-going research and latest developments.
Clinical significance of high anti-entamoeba histolytica antibody titer in asymptomatic HIV-1-infected individuals.

BACKGROUND Anti-Entamoeba histolytica antibody (anti- E. histolytica) is widely used in seroprevalence studies though its clinical significance has not been assessed previously. METHODS Anti-E. histolytica titer was measured at first visit to our clinic (baseline) in 1303 patients infected with human immunodeficiency virus type 1 (HIV-1). The time to diagnosis of invasive amebiasis was assessed by Kaplan-Meier method and risk factors for the development of invasive amebiasis were assessed by Cox proportional-hazards regression analysis. For patients who developed invasive amebiasis, anti-E. histolytica titers at onset were compared with those at baseline and after treatment. RESULTS The anti-E. histolytica seroprevalence in the study population was 21.3% (277/1303). Eighteen patients developed invasive amebiasis during the treatment-free period among 1207 patients who had no history of previous treatment with nitroimidazole. Patients with high anti-E. histolytica titer at baseline developed invasive amebiasis more frequently than those with low anti-E. histolytica titer. Most cases of invasive amebiasis who had high anti-E. histolytica titer at baseline developed within 1 year. High anti-E. histolytica titer was the only independent predictor of future invasive amebiasis. Anti-E. histolytica titer was elevated at the onset of invasive amebiasis in patients with low anti-E. histolytica titer at baseline. CONCLUSIONS Asymptomatic HIV-1-infected individuals with high anti-E. histolytica titer are at risk of invasive amebiasis probably due to exacerbation of subclinical amebiasis.
Hedging and Portfolio Optimization in Financial Markets with a Large Trader

We introduce a general continuous‐time model for an illiquid financial market where the trades of a single large investor can move market prices. The model is specified in terms of parameter‐dependent semimartingales, and its mathematical analysis relies on the nonlinear integration theory of such semimartingale families. The Itô–Wentzell formula is used to prove absence of arbitrage for the large investor, and, using approximation results for stochastic integrals, we characterize the set of approximately attainable claims. We furthermore show how to compute superreplication prices and discuss the large investor's utility maximization problem.