Miracle-dz/UniFAR-FTUs huggingface dataset:
Obesity negatively impacts outcome in elderly female patients with aggressive B‐cell lymphomas treated with R‐CHOP : results from prospective trials of the German high grade non‐Hodgkin's lymphoma trial group

To study if obesity is a risk factor in elderly patients (>60 years) with aggressive B‐cell lymphoma, the outcomes of 576 elderly patients treated with rituximab in the RICOVER‐60 trial were analysed in a retrospective study with regard to body mass index (BMI) and gender. Of the 576 patients, 1% had low body weight (BMI < 18·5), 38% were normal weight (18·5 ≤ BMI < 25), 42% were overweight (25 ≤ BMI < 30) and 19% were obese (BMI ≥ 30). Event‐free (EFS), progression‐free (PFS) and overall survival (OS) according to BMI showed no significant differences for all and for male patients. EFS (P = 0·041), PFS (P = 0·038) and OS (P = 0·031) were significantly better for female non‐obese patients. A multivariate analysis adjusted for International Prognostic Index risk factors confirmed these results, with the following hazard ratios (HR) for obesity (BMI ≥ 30) for EFS/PFS/OS: all patients – 1·4/1·4/1·4 (not significant); male patients – 1·2/1·2/1·0 (not significant) and female patients – 1·7 (P = 0·032)/1·9 (P = 0·022)/2·0 (P = 0·017). In conclusion, obesity is a risk factor that influences treatment outcome in elderly female patients with aggressive B‐cell lymphoma treated with R‐CHOP (rituximab + cyclophosphamide, doxorubicin, vincristine, prednisolone). The inferior outcomes in obese female patients may be due to faster rituximab clearance in obese females.
Development of sputtered high temperature coatings for thrust chambers

Adherent insulating coatings were developed for thrust chamber service. The coatings consisted of nickel and a ceramic, and were graded in composition from pure nickel at the thrust chamber wall to pure ceramic at the coating surface. The coatings were deposited by rf sputtering from a target with a reversed composition gradient, which was produced by plasma spraying powder mixtures. The effect of deposition parameters on coating characteristics and adherence is discussed.
Geochronology and geochemistry of high‐pressure granulites of the Arthur River Complex, Fiordland, New Zealand: Cretaceous magmatism and metamorphism on the palaeo‐Pacific Margin

The Arthur River Complex is a suite of gabbroic to dioritic orthogneisses in northern Fiordland, New Zealand. The Arthur River Complex separates rocks of the Median Tectonic Zone, a Mesozoic island arc complex, from Palaeozoic rocks of the palaeo‐Pacific Gondwana margin, and is itself intruded by the Western Fiordland Orthogneiss. New SHRIMP U/Pb single zircon data are presented for magmatic, metamorphic and deformation events in the Arthur River Complex and adjacent rocks from northern Fiordland. The Arthur River Complex orthogneisses and dykes are dominated by magmatic zircon dated at 136–129 Ma. A dioritic orthogneiss that occurs along the eastern margin of the Complex is dated at 154.4 ± 3.6 Ma and predates adjacent plutons of the Median Tectonic Zone. Rims on zircon cores from this sample record a thermal event at c. 120 Ma, attributed to the emplacement of the Western Fiordland Orthogneiss. Migmatitic Palaeozoic orthogneiss from the Arthur River Complex (346 ± 6 Ma) is interpreted as deformed wall rock. Very fine rims (5–20 µm) also indicate a metamorphic age of c. 120–110 Ma. A post‐tectonic pegmatite (81.8 ± 1.8 Ma) may be related to phases of crustal extension associated with the opening of the Tasman Sea. The Arthur River Complex is interpreted as a batholith, emplaced at mid‐crustal levels and then buried to deep crustal levels due to convergence of the Median Tectonic Zone arc and the continental margin.
The replacement of assertive outreach services by reinforcing local community teams: a replication study reporting comparative outcomes and patient reported experience

Abstract Background: This is the third in a series of papers on patient outcomes and other consequences of the withdrawal of specialist assertive outreach (AO) teams. We previously reported positive outcomes for patients receiving a less intensive service at up to four years, but had not systematically interviewed patients. Aims: To test the generalizability of earlier findings through replication in another service. To complement the analysis of service utilisation with patient reported experience between the two treatment models. Methods: Service level evaluation 12 months pre and post service change for 55 eligible AO patients. Thirty three consenting patients answered validated questionnaires. Results: There were no statistically significant changes in hospital bed use comparing the year before and the year after the change (850–712 bed days, median 34–20). No significant change in crisis activity occurred despite a highly significant reduction in face to face contacts from a mean of 90–40. There were no significant changes in patient reported experience. Conclusions: Results are consistent with earlier studies. Reinforcing community mental health teams can provide an integrated service model that is clinically effective and equally acceptable to patients, making this a viable and affordable alternative to orthodox AO teams.
Synthesis of graphene nanomaterials and their application in electrochemical energy storage

Xiong, Guoping. Ph.D., Purdue University, December 2013. Synthesis of Graphene Nanomaterials and Their Application in Electrochemical Energy Storage. Major Professor: Timothy S. Fisher, School of Mechanical Engineering. The need to store and use energy on diverse scales in a modern technological society necessitates the design of large and small energy systems, among which electrical energy storage systems such as batteries and capacitors have attracted much interest in the past several decades. Supercapacitors, also known as ultracapacitors, or electrochemical capacitors, with fast power delivery and long cycle life are complementing or even replacing batteries in many applications. The rapid development of miniaturized electronic devices has led to a growing need for rechargeable micropower sources with high performance. Among different sources, electrochemical microcapacitors or micro-supercapacitors provide higher power density than their counterparts and are gaining increased interest from the research and engineering communities. Rechargeable Li ion batteries with high energy and power density, long cycling life, high charge–discharge rate (1C – 3C) and safe operation are in high demand as power sources and power backup for hybrid electric vehicles and other applications. In the present work, graphene-based graphene materials have been designed and synthesized for electrochemical energy storage applications, e.g., conventional supercapacitors (macro-supercapacitors), microsupercapacitors and lithium ion batteries.
How to make a mature accreting magnetar

Several candidates for accreting magnetars have been proposed recently by different authors. Existence of such systems contradicts the standard magnetic field decay scenario where a large magnetic field of a neutron star reaches $\lesssim$ few$\times 10^{13}$G at ages $\gtrsim 1$ Myr. Among other sources, the high mass X-ray binary 4U0114+65 seems to have a strong magnetic field around $10^{14}$ G. We develop a new Bayesian estimate for the kinematic age and demonstrate that 4U0114+65 has kinematic age 2.4-5 Myr ($95\%$ credential interval) since the formation of the neutron star. We discuss which conditions are necessary to explain the potential existence of magnetars in accreting high-mass binaries with ages about few Myrs and larger. Three necessary ingredients are: the Hall attractor to prevent rapid decay of dipolar field, relatively rapid cooling of the crust in order to avoid Ohmic decay due to phonons, and finally, low values of the parameter $Q$ to obtain long Ohmic time scale due to impurities. If age and magnetic field estimates for proposed accreting magnetars are correct, then these systems set the strongest limit on the crust impurity for a selected sample of neutron stars and provide evidence in favour of the Hall attractor.
A community based mobility model for ad hoc network research

Validation of mobile ad hoc network protocols relies almost exclusively on simulation. The value of the validation is, therefore, highly dependent on how realistic the movement models used in the simulations are. Since there is a very limited number of available real traces in the public domain, synthetic models for movement pattern generation must be used. However, most widely used models are currently very simplistic, their focus being ease of implementation rather than soundness of foundation. As a consequence, simulation results of protocols are often based on randomly generated movement patterns and, therefore, may differ considerably from those that can be obtained by deploying the system in real scenarios. Movement is strongly affected by the needs of humans to socialise or cooperate, in one form or another. Fortunately, humans are known to associate in particular ways that can be mathematically modelled and that have been studied in social sciences for years.In this paper we propose a new mobility model founded on social network theory. The model allows collections of hosts to be grouped together in a way that is based on social relationships among the individuals. This grouping is then mapped to a topographical space, with movements influenced by the strength of social ties that may also change in time. We have validated our model with real traces by showing that the synthetic mobility traces are a very good approximation of human movement patterns.
Organization of choroid plexus epithelial and endothelial cell tight junctions and regulation of claudin‐1, ‐2 and ‐5 expression by protein kinase C

&NA; Claudins are components of the tight junctional complex in epithelial and endothelial cells. We characterized the composition of tight junctions in the choroid plexus of the lateral ventricle in the rat brain and tested whether protein kinase C induced changes in their composition. Claudin‐1, −2 and −5 were present in the epithelial cells at and near the tight junctions, respectively. In the endothelial cells, claudin‐5 was stronger expressed than claudin‐1 and ‐2. Twenty‐four hours after the phorbolester injection into the ventricle, claudin‐1 immunoreactivity of the epithelial cells was increased and spread to the cytoplasm. The claudin‐2 and ‐5 immunoreactivities were reduced. These findings are consistent with an influence of protein kinase C on the composition of the tight junctions in the choroid plexus.
EFEKAT LOKALNE PRIMENE PLAZME BOGATE TROMBOCITIMA I VO \ ENE

Osseointegration is a result of cellular migration, differentiation, bone formation, and bone remodelling on the surface of an implant. Each of these processes depends on platelets and blood coagulum. Platelet-rich plasma (PRP) is used to improve osseointegration and stability of implants. It is a blood fraction produced in a centrifuge which contains a high concentration of platelets. Platelets contain numerous growth factors which influence tissue reactions. The aim of the research is to test clinically the influence of PRP and guided tissue regeneration in bone defects on dental implant stability with early insertion. An experimental study has been done on 10 experimental dogs. 40 BCT implants were inserted, 4 for each dog (two on the left side and two on the right side, with guided tissue regeneration). Mobility of the implants was measured with the Periotest tool, first immediately after insertion and then 10 weeks after insertion. Results of measuring implant mobility according to the Periotest scale showed that all four groups of implants can be classified as belonging to the 0 degree implant mobility group. On the basis of the results we conclude that the mobility of dental implants was lowest in the protocol where PRP was applied combined with bovine deproteinized bone and resorbable membrane of bovine origin.
On the nonexistence of $[\binom{2m}{m-1}, 2m, \binom{2m-1}{m-1}]$, $m$ odd, complex orthogonal design

Complex orthogonal designs (CODs) are used to construct space-time block codes. COD $\mathcal{O}_z$ with parameter $[p, n, k]$ is a $p\times n$ matrix, where nonzero entries are filled by $\pm z_i$ or $\pm z^*_i$, $i = 1, 2,. , k$, such that $\mathcal{O}^H_z \mathcal{O}_z = (|z_1|^2+|z_2|^2+.+|z_k|^2)I_{n \times n}$. Adams et al. in "The final case of the decoding delay problem for maximum rate complex orthogonal designs," IEEE Trans. Inf. Theory, vol. 56, no. 1, pp. 103-122, Jan. 2010, first proved the nonexistence of $[\binom{2m}{m-1}, 2m, \binom{2m-1}{m-1}]$, $m$ odd, COD. Combining with the previous result that decoding delay should be an integer multiple of $\binom{2m}{m-1}$, they solved the final case $n \equiv 2 \pmod 4$ of the decoding delay problem for maximum rate complex orthogonal designs. In this paper, we give another proof of the nonexistence of COD with parameter $[\binom{2m}{m-1}, 2m, \binom{2m-1}{m-1}]$, $m$ odd. Our new proof is based on the uniqueness of $[\binom{2m}{m-1}, 2m-1, \binom{2m-1}{m-1}]$ under equivalence operation, where an explicit-form representation is proposed to help the proof. Then, by proving it's impossible to add an extra orthogonal column on COD $[\binom{2m}{m-1}, 2m-1, \binom{2m-1}{m-1}]$ when $m$ is odd, we complete the proof of the nonexistence of COD $[\binom{2m}{m-1}, 2m, \binom{2m-1}{m-1}]$.
Health information needs of pregnant women: information sources, motives and barriers

BACKGROUND Pregnant women should be provided with relevant and useful information to manage this specific period of their lives. Assessing information needs of this group is a prerequisite for providing this information. OBJECTIVE The aim of this study was to assess the information needs of pregnant women during their pregnancy and childbirth. METHODS This descriptive study was conducted on the pregnant women who attended antenatal clinics and obstetricians/gynaecologists' offices in Kerman, Iran, in 2015. Data were collected using a self-administered, valid and reliable questionnaire. A total of 400 women participated in the study. FINDINGS Most pregnant women needed information about care of the foetus (n = 344, 86%), physical and psychological complications after delivery (n = 333, 83%), development and growth of the foetus (n = 330, 82.5%), pregnancy nutrition (n = 327, 82%) and special tests during pregnancy (n = 326, 81.5%). They mostly (n = 195, 49%) looked for information when they were suffering from a disease or pregnancy complications. CONCLUSIONS As pregnant women need extensive information to be able to take care of themselves and their babies, their information needs should be identified and taken into consideration when planning educational programmes for this group of women.
Regulation of inflammatory responses by dynamic subcellular localization of RNA-binding protein Arid5a

Significance Immune cell activation is accompanied by dynamic changes in expression of genes related to inflammation. Concomitantly, immune reactions are tightly controlled to prevent harmful pathologies due to sustained inflammation. Gene expression is controlled at multiple checkpoints. Among these, the post-transcriptional regulation of the balance between Arid5a and Regnase-1 is important for the induction of inflammation. Our findings provide important insight into the role of the regulation of nucleocytoplasmic localization of Arid5a in the development of inflammation through the induction of a change in the ratio of Arid5a to Regnase-1. Adenine-thymine (AT)-rich interactive domain 5a (Arid5a) is an RNA-binding protein found in the cytoplasm and nucleus of normally growing cells. Although Arid5a is known to play an important role in immune regulation, whether and how Arid5a subcellular localization impacts immune regulation has remained unclear. In this study, we generated Arid5a transgenic (TG) mice to address this question. While ectopic Arid5a overexpression did not affect expression of inflammatory cytokines under unstimulated conditions, significantly higher levels of inflammatory cytokines, such as IL-6, were produced in response to lipopolysaccharide (LPS) stimulation. Consistent with this, TG mice were more sensitive to LPS treatment than wild-type mice. We also found that Arid5a is imported into the nucleus via a classical importin-α/β1–mediated pathway. On stimulation, nuclear Arid5a levels were decreased, while there was a concomitant increase in cytoplasmic Arid5a. Arid5a is associated with up-frameshift protein 1, and its nuclear export is regulated by a nuclear export receptor, chromosomal region maintenance 1. Taken together, these data indicate that Arid5a is a dynamic protein that translocates to the cytoplasm from the nucleus so as to properly exert its dual function in mRNA stabilization and transcriptional regulation during inflammatory conditions.
Properties of Graphite Fiber Reinforced Copper Matrix Composites for Space Power Applications

The thermal and mechanical properties of pitch-based graphite fiber reinforced copper matrix (Gr/Cu) composites usable for space applications such as radiator fins were investigated. Thermal conductivity was measured as a function of fiber volume fraction and architecture. Results showed for unidirectional P-100 Gr/Cu composites, the longitudinal thermal conductivity was nearly independent of fiber volume fraction. Transverse thermal conductivities (perpendicular to the fibers) were strongly affected by the fiber volume fraction with higher volume fractions resulting in lower thermal conductivities. The effect of architecture on thermal conductivity followed the cosine squared law for simple architectures. Insufficient data are available currently to model more complex architectures, but adding fibers in the direction of the heat flow increases the thermal conductivity as low conductivity plies are supplemented by high conductivity plies. Thermal expansion tests were conducted on the Gr fibers and Gr/Cu composites. The results show a considerable thermal expansion mismatch between the fibers and the Cu matrix. The longitudinal thermal expansion showed a strong dependence on the architecture of the Gr/Cu composites. The composites also show a thermal expansion hysteresis. The hysteresis was eliminated by an engineered interface. Mechanical testing concentrated on the dynamic modulus and strength of the composites. The dynamic modulus of the Gr/Cu composites was 305 GPa up to 400 C, a value equivalent to Be. The strengths of the composites were less than expected, but this is attributed to the poor bond across the interface between the Gr fibers and Cu matrix. Testing of composites with an engineered interface is expected to yield strengths nearer the values predicted by the rule of mixtures.
Tissue Engineering: Engineering Principles for the Design of Replacement Organs and Tissues

PART 1: TISSUE EXCHANGE AND TISSUE DEVELOPMENT 1. The State-of-the-Art in Tissue Exchange 2. Objectives of Tissue Engineering 3. Elements of Tissue Development PART 2: TISSUE ENGINEERING FUNDAMENTALS 4. Cell Growth and Differentiation 5. Cell and Tissue Mechanics 6. Cell Adhesion 7. Cell Migration 8. Cell Aggregation and Tissue Equivalents 9. Tissue Barriers to Molecular and Cellular Transport PART 3: TISSUE ENGINEERING PRACTICE 10. Cell Delivery and Recirculation 11. Delivery of Molecular Agents in Tissue Engineering 12. Cell Interactions With Polymers 13. Approaches to Tissue Engineering 14. Case Studies in Tissue Engineering Appendices A. Introduction to Polymers B. Analysis of Molecular Transport C. Useful Data D. Nomenclature and Abbreviations
Flavodiiron Protein Substitutes for Cyclic Electron Flow without Competing CO2 Assimilation in Rice1[OPEN]

A moss flavodiiron protein can substitute the function of cyclic electron transport around photosystem I without any decrease in CO2 assimilation or biomass production in rice. Flavodiiron protein (FLV) mediates photoreduction of O2 to H2O. It is conserved from cyanobacteria to gymnosperms but not in angiosperms. The introduction of a moss (Physcomitrella patens) FLV (PpFLV) gene into Arabidopsis (Arabidopsis thaliana) made photosystem I (PSI) resistant to fluctuating light. Here, we used the same strategy with three rice (Oryza sativa) genotypes. PpFLV in the wild-type rice background functioned as an efficient PSI electron sink and increased resistance to PSI photodamage under fluctuating light. The introduction of PpFLV into the PGR5-RNAi mutant [defective in PROTON GRADIENT REGULATION5 (PGR5)-dependent cyclic electron transport around PSI, CET-PSI], the crr6 mutant [defective in chloroplast NAD(P)H-dehydrogenase-like complex (NDH)-dependent CET-PSI], and the PGR5-RNAi crr6 double mutant (double defective in CET-PSI activity) alleviated PSI photodamage under fluctuating light. Furthermore, PpFLV substituted for the function of PGR5- and NDH-dependent CET-PSI without competing for CO2 assimilation under constant light, as there was no difference in CO2 assimilation per Rubisco content and biomass production was recovered to the wild-type level. Thus, the exogenous FLV system could act not only as a safety valve under fluctuating light, but also generate a proton motive force for balancing the ATP/NADPH production ratio during steady-state photosynthesis.
Characterizing Implicit Bias in Terms of Optimization Geometry

We study the implicit bias of generic optimization methods, such as mirror descent, natural gradient descent, and steepest descent with respect to different potentials and norms, when optimizing underdetermined linear regression or separable linear classification problems. We explore the question of whether the specific global minimum (among the many possible global minima) reached by an algorithm can be characterized in terms of the potential or norm of the optimization geometry, and independently of hyperparameter choices such as step-size and momentum.
Synthetic or Real? The Equilibrium Effects of Credit Default Swaps on Bond Markets

We provide a model of nonredundant credit default swaps (CDSs), building on the observation that CDSs have lower trading costs than bonds. CDS introduction involves a trade-off: it crowds out existing demand for the bond, but improves the bond allocation by allowing long-term investors to become levered basis traders and absorb more of the bond supply. We characterize conditions under which CDS introduction raises bond prices. The model predicts a negative CDS-bond basis, as well as turnover and price impact patterns that are consistent with empirical evidence. We also show that a ban on naked CDSs can raise borrowing costs.
The Spectrum of ELANE Mutations and their Implications in Severe Congenital and Cyclic Neutropenia

Neutrophil elastase gene (ELANE) mutations are responsible for the majority of cases of severe congenital neutropenia (CN) and cyclic neutropenia (CyN). We screened CN (n = 395) or CyN (n = 92) patients for ELANE mutations and investigated the impact of mutations on mRNA expression, protein expression, and activity. We found 116 different mutations in 162 (41%) CN patients and 26 in 51 (55%) CyN patients, 69 of them were novel. CyN‐associated mutations were predicted to be more benign than CN‐associated mutations, but the mutation severity largely overlapped. The frequency of acquired CSF3R mutations, malignant transformation, and the need for hematopoietic stem cell transplantation was significantly higher in CN patients with ELANE mutation than in ELANE mutation negative patients. Cellular elastase activity was reduced in neutrophils from CN/CyN patients, irrespective of the mutation status. In CN, enzymatic activity was significantly lower in patients with ELANE mutations compared with those with wild‐type ELANE. Despite differences in the spectrum of mutations in CN or CyN, type or localization of mutation only partially determine the clinical phenotype. Specific ELANE mutations have limited predictive value for leukemogenesis; the risk for leukemia was correlated with disease severity rather than with occurrence of an ELANE mutation.