Miracle-dz/UniFAR-FTUs huggingface dataset:
Schema- and Data-driven Discovery of SQL Keys

Keys play a fundamental role in all data models. They allow database systems to uniquely identify data items, and therefore, promote efficient data processing in many applications. Due to this, support is required to discover keys. These include keys that are semantically meaningful for the application domain, or are satisfied by a given database. We study the discovery of keys from SQL tables. We investigate the structural and computational properties of Armstrong tables for sets of SQL keys. Inspections of Armstrong tables enable data engineers to consolidate their understanding of semantically meaningful keys, and to communicate this understanding to other stake-holders. The stake-holders may want to make changes to the tables or provide entirely different tables to communicate their views to the data engineers. For such a purpose, we propose data mining algorithms that discover keys from a given SQL table. We combine the key mining algorithms with Armstrong table computations to generate informative Armstrong tables, that is, key-preserving semantic samples of existing SQL tables. Finally, we define formal measures to assess the distance between sets of SQL keys. The measures can be applied to validate the usefulness of Armstrong tables, and to automate the marking and feedback of non-multiple choice questions in database courses. Category: Smart and intelligent computing
Investigation of KIF6 Trp719Arg in a Case-Control Study of Myocardial Infarction: A Costa Rican Population

Background and Methodology The 719Arg allele of KIF6 (rs20455) was associated with coronary events in Caucasian participants of five prospective studies. We investigated whether this KIF6 variant was associated with non-fatal myocardial infarction (MI) in a case-control study of an admixed population from the Central Valley of Costa Rica. Genotypes of the KIF6 variant were determined for 4,134 men and women. Cases (1,987) had survived a first MI; controls (2,147) had no history of MI and were matched to cases by age, sex, and area of residence. We tested the association between the KIF6 719Arg allele and non-fatal MI by conditional logistic regression and adjusted for admixture of founder populations. Principal Findings Compared with the reference Trp/Trp homozygotes, KIF6 719Arg carriers were not at significantly higher risk for non-fatal MI in this study after adjustment for traditional risk factors or admixture (OR = 1.12; 95%CI, 0.98–1.28). Heterozygotes of the KIF6 Trp719Arg variant were at increased risk of non-fatal MI: the adjusted odds ratio was 1.16 (95% confidence interval, 1.01–1.34), but this association would not be significant after a multiple testing correction. Conclusions/Significance We found that carriers of the KIF6 719Arg allele were not at increased risk of non-fatal MI in a case-control study of Costa Ricans living in the Central Valley of Costa Rica.
Not going to take this anymore: Multi-objective overtime planning for Software Engineering projects

Software Engineering and development is well-known to suffer from unplanned overtime, which causes stress and illness in engineers and can lead to poor quality software with higher defects. In this paper, we introduce a multi-objective decision support approach to help balance project risks and duration against overtime, so that software engineers can better plan overtime. We evaluate our approach on 6 real world software projects, drawn from 3 organisations using 3 standard evaluation measures and 3 different approaches to risk assessment. Our results show that our approach was significantly better (p <; 0.05) than standard multi-objective search in 76% of experiments (with high Cohen effect size in 85% of these) and was significantly better than currently used overtime planning strategies in 100% of experiments (with high effect size in all). We also show how our approach provides actionable overtime planning results and investigate the impact of the three different forms of risk assessment.
Regulation of Adeno-Associated Virus DNA Replication by the Cellular TAF-I/Set Complex

ABSTRACT The Rep proteins of the adeno-associated virus (AAV) are required for viral replication in the presence of adenovirus helper functions and as yet poorly characterized cellular factors. In an attempt to identify such factors, we purified Flag-Rep68-interacting proteins from human cell lysates. Several polypeptides were identified by mass spectrometry, among which was ANP32B, a member of the acidic nuclear protein 32 family which takes part in the formation of the template-activating factor I/Set oncoprotein (TAF-I/Set) complex. The N terminus of Rep was found to specifically bind the acidic domain of ANP32B; through this interaction, Rep was also able to recruit other members of the TAF-I/Set complex, including the ANP32A protein and the histone chaperone TAF-I/Set. Further experiments revealed that silencing of ANP32A and ANP32B inhibited AAV replication, while overexpression of all of the components of the TAF-I/Set complex increased de novo AAV DNA synthesis in permissive cells. Besides being the first indication that the TAF-I/Set complex participates in wild-type AAV replication, these findings have important implications for the generation of recombinant AAV vectors since overexpression of the TAF-I/Set components was found to markedly increase viral vector production.
[Restraint variables in a regional mental health hospital in Turkey].

OBJECTIVE To obtain a database to be used in the effort to reduce the use of restraint in mental health hospitals in Turkey, and to compare the data with results of similar studies. METHOD The sociodemographic characteristics, history of violent or suicidal behavior, and BPRS scores of patients restrained during a 1-month period, and data concerning the number of beds and staff working during day and night shifts were collected. The restraint variables, number of restraints used and duration of restraint use, in all wards were determined and adult psychosis wards were compared according to these variables. RESULTS Approximately 25% (194) of 810 hospitalized patients were restrained for a total of 1524.25 h (mean: 3.25 h) during 1 month. In all, 182 restrained patients were analyzed and most were male, elementary school graduates, never married, and living with first-degree relatives. There were no correlations between these variables, and the number of restraints used and the duration of their use. Mean age of the females (36.27 years) was higher than that of the males (32.46 years); the difference was significant. In all, 66.6% of restraint use was because of violent behavior or the probability of violent behavior. The rate of restraint use was lower during day shifts (43.82%). Patients on adult wards were not different in terms of diagnosis, BPRS score, rate of violent behavior, and reasons for using restraint, but were markedly different in terms of the number of restraints used and the duration of restraint. CONCLUSION The number of restraints used and the duration of restraint was on average level. Restraint was associated with being female and older, and having more severe symptoms. Night and weekend shifts were more risky for amount and duration of restraint. Non-clinical institutional factors were a determining factor in the use of restraint.
Effect of Buccal Gap Distance on Alveolar Ridge Alteration After Immediate Implant Placement: A Microcomputed Tomographic and Morphometric Analysis in Dogs

Introduction:The buccal bone resorption and the deformation of soft tissue contour are major problems of immediate implant treatment. This study aims to examine the changes of alveolar bone and soft tissue after immediate implant placement in different buccal gap distances. Materials and Methods:Eight implants were placed randomly in the mandibular premolar sockets of 6 hybrid dogs with 1, 2, and 3 mm buccal gap distances. The dogs were killed after 2 or 4 months for morphometric and microcomputed tomography analyses. Discussion:After 2 months, the 3-mm group had the highest buccal bone volume (BV), buccal bone/soft tissue thickness, and the lowest bone resorption. The wider the buccal gap, the more buccal bone and soft tissue were formed in this experimental setting. After 4 months, the buccal BV had decreased significantly in the 1-mm and the 2-mm groups, whereas the 3-mm group resisted to buccal bone resorption. This difference was more pronounced at the crest. Conclusion:The 3 mm is the optimal gap distance among the groups examined, which drastically influences the healing of bone and soft tissue surrounding the implants.
The C terminus of NS5A domain II is a key determinant of hepatitis C virus genome replication, but is not required for virion assembly and release

The NS5A protein of hepatitis C virus (HCV) plays roles in both virus genome replication and the assembly of infectious virus particles. NS5A comprises three domains, separated by low-complexity sequences. Whilst the function of domain I appears to be predominantly involved with genome replication, the roles of domains II and III are less well defined. It has been reported previously that a deletion spanning the majority of domain II but retaining the C-terminal 35 residues had no effect on virus production; however, deletion of the entire domain II eliminated genome replication, pointing to a key role for the C terminus of this domain. Recent work has also highlighted this region as the potential binding site of the host factor cyclophilin A (CypA). To define this requirement for replication in more detail, and to investigate the involvement of CypA, we conducted a mutagenic study of the C-terminal 30 residues of domain II within the context of both the infectious JFH-1 virus and a JFH-1-derived subgenomic replicon. We showed that 12 of these residues were absolutely required for virus genome replication, whilst mutations of the remainder either had no phenotype or exhibited a partial reduction in genome replication. There was an absolute correlation between the datasets for virus and subgenomic replicon, indicating that this region is involved solely in the process of genome replication. Comparison of our data with a previously published analysis of the same region in genotype 1b revealed some important differences between the two genotypes of HCV.
Relationship between chronic otitis media with effusion and overweight or obesity in children

Abstract Objectives: Otitis media with effusion and obesity are both common in childhood and might share some immunological alterations. This study aimed to investigate the relationship between chronic otitis media with effusion and childhood overweight or obesity, including the potential effects of adenoid or tonsillar hypertrophy on that relationship. Methods: This study included 60 children with chronic otitis media with effusion and 86 healthy children aged from 2 to 10 years. Measures of height and weight were used to calculate the body mass index, weight for height and weight z score. Results: The prevalence of overweight or obesity was higher in children with chronic otitis media with effusion, according to the weight for height percentiles (p = 0.012). However, neither the presence of adenoid or tonsillar hypertrophy nor the degree of adenoid hypertrophy was associated with overweight or obesity. Conclusion: Overweight and obesity might be risk factors for developing chronic otitis media with effusion, or vice versa.
Distinct CpG DNA and Polyinosinic-Polycytidylic Acid Double-Stranded RNA, Respectively, Stimulate CD11c− Type 2 Dendritic Cell Precursors and CD11c+ Dendritic Cells to Produce Type I IFN1

Two classes of nucleic acids, bacterial DNA containing unmethylated CpG motifs and dsRNA in viruses, induce the production of type I IFN that contributes to the immunostimulatory effects of these microbial molecules. Thus, it is important to determine which cells produce type I IFN in response to CpG DNA and dsRNA. CD4+CD11c− type 2 dendritic cell precursors (pre-DC2) were identified as the main producers of type I IFN in human blood in response to viruses. Here we asked whether pre-DC2 also produce type I IFN in response to CpG DNA and dsRNA. Oligodeoxynucleotides containing particular palindromic CpG motifs induced pre-DC2, but not CD11c+ blood DC or monocytes, to produce IFN-α. In contrast, a synthetic dsRNA, polyinosinic polycytidylic-acid, induced CD11c+ DC, but not pre-DC2 or monocytes, to produce IFN-αβ. These data indicate that CpG DNA and polyinosinic-polycytidylic acid stimulate different types of cells to produce type I IFN and that it is important to select oligodeoxynucleotides containing particular CpG motifs to induce pre-DC2 to produce type I IFN, which may play a key role in the strong adjuvant effects of CpG DNA.
Enhanced pulmonary expression of the TrkB neurotrophin receptor in hypoxic rats is associated with increased acetylcholine‐induced airway contractility

Aim: We have recently reported that hypoxia stimulates transcription of the TrkB neurotrophin receptor in cultured cells via stabilization of hypoxia‐inducible factor‐1α. Here we investigated whether the expression of TrkB and other neurotrophin receptors is oxygen‐sensitive also in vivo, and explored the functional consequences of an oxygen‐regulated TrkB expression.
Decimal Floating Point Multiplication using RPS Algorithm

Floating-point representation can support a much wider range of values over fixed point representation. The performance of decimal floating-point operations is an important measure in many application domains such as financial, commercial, and internet-based computations. In this research, an iterative decimal floating-point multiplier design in IEEE 754-2008 format is proposed. This design uses a decimal fixed point multiplier using RPS algorithm that generates partial products for column accumulation from the least significant end in an iterative manner. It also incorporates the necessary decimal floating-point exponent processing, rounding and exception detection capability. The rounding process is initiated in parallel with the decimal fixed point multiplication of significand digits. The intermediate exponent, the product sign, sticky bit, round digit and the guard digit are determined on the fly with the accumulation of partial products. Simulation result for a 32-bit data in comparison with the existing designs in literature gives a delay reduction of 25.12%. General Terms Decimal arithmetic, VLSI Design.
Dimerization of Protein Tyrosine Phosphatase σ Governs both Ligand Binding and Isoform Specificity

ABSTRACT Signaling through receptor protein tyrosine phosphatases (RPTPs) can influence diverse processes, including axon development, lymphocyte activation, and cell motility. The molecular regulation of these enzymes, however, is still poorly understood. In particular, it is not known if, or how, the dimerization state of RPTPs is related to the binding of extracellular ligands. Protein tyrosine phosphatase σ (PTPσ) is an RPTP with major isoforms that differ in their complements of fibronectin type III domains and in their ligand-binding specificities. In this study, we show that PTPσ forms homodimers in the cell, interacting at least in part through the transmembrane region. Using this knowledge, we provide the first evidence that PTPσ ectodomains must be presented as dimers in order to bind heterophilic ligands. We also provide evidence of how alternative use of fibronectin type III domain complements in two major isoforms of PTPσ can alter the ligand binding specificities of PTPσ ectodomains. The data suggest that the alternative domains function largely to change the rotational conformations of the amino-terminal ligand binding sites of the ectodomain dimers, thus imparting novel ligand binding properties. These findings have important implications for our understanding of how heterophilic ligands interact with, and potentially regulate, RPTPs.
The Effect of Milankovitch Variations in Insolation on Equatorial Seasonality

Although the sun crosses the equator 2 times per year at the equinoxes, at times in the past the equatorial insolation has had only one maximum and one minimum throughout the seasonal cycle because of Milankovitch orbital variations. Here a state-of-the-art coupled atmosphere‐ocean general circulation model is used to study the effect of such insolation forcing on equatorial surface properties, including air and sea temperature, salinity, winds, and currents. It is shown that the equatorial seasonality is altered according to the insolation with, for example, either maximum sea surface temperature (SST) close to the vernal equinox and minimum SST close to the autumnal equinox or vice versa. The results may have important implications for understanding tropical climate as well as for the interpretation of proxy data collected from equatorial regions.
The effect of social cues on the eating behavior of obese and normal subjects.

Schachter's externality hypothesis suggests that overweight individuals are more likely to be induced to eat by salient external cues than normal weight individuals. While a range of studies have demonstrated the plausibility of this hypothesis in the case of sensory stimuli (e.g., taste cues), there is little evidence that the hypothesis applies to social stimuli. The current study examines this latter proposition by exposing male and female, overweight and normal weight subjects to a same-sex or opposite-sex peer model. Under the guise of engaging in a taste experiment, the subjects were either exposed to a model who tasted no crackers (no eat), one cracker (low eat), or twenty crackers (high eat). In addition, control model-absent conditions were also run for purposes of establishing baseline eating rates. If the externality hypotheses were to prevail in social domains, one would expect overweight subjects to be more prone to model the cracker-eating behavior of the peer than normal weight individuals. However, the findings indicate that all subject groups regardless of weight evidence a rather clear modeling effect and all subjects evidence social inhibition effects on their eating behavior as well. Several intriguing interactions among subject sex, model sex, subject weight, and social condition were also found. The discussion explores the relevance of an externality model of overweight eating in social domains, and focuses upon the interesting and somewhat distinct pattern of socially mediated eating exhibited by overweight females.
Bioadhesive delivery systems for mucosal vaccine delivery

Mucosal vaccine delivery potentially induces mucosal as well as systemic immune responses and may have advantages particularly for optimal protection against pathogens that infect the host through mucosal surfaces. However, the delivery of antigens through mucosal membranes remains a major challenge due to unfavorable physiological conditions (pH and enzymes) and significant biological barriers, which restrict the uptake of antigens. To improve mucosal vaccine delivery, the use of bioadhesive delivery systems offers numerous advantages, including protection from degradation, increasing concentration of antigen in the vicinity of mucosal tissue for better absorption, extending their residence time, and/or targeting them to sites of antigen uptake. Although some bioadhesives have direct immune stimulating properties, it appears most likely that successful mucosal vaccination will require the addition of vaccine adjuvants for optimal immune responses, particularly if they are to be used in an unprimed population. Thus, complex vaccine formulations and delivery strategies have to be carefully designed to appropriately stimulate immune response for the target pathogen. In addition, careful consideration is needed to define the “best” route for mucosal immunization for each individual pathogen.
A study of 25 zygomatic dental implants with 11 to 49 months' follow-up after loading.

PURPOSE The purpose of this study was to evaluate indications, surgical problems, complications, and treatment outcomes related to the placement of zygomatic implants. A second aim was to determine any prosthetic difficulties and complications. MATERIALS AND METHODS Twenty-five zygomatic implants were placed in 13 patients between April 1999 and December 2001. The patient age range was between 49 and 73 years, with a mean age of 59 years. All patients showed severe resorption of alveolar bone in the maxilla. All but 2 patients were smokers. Two patients had a history of cleft palate surgery, and 2 patients were known to be bruxers. Standard recommended surgical protocol was followed, and treatment was performed under general anesthesia. After abutment surgery, 9 patients received bar-retained overdentures, and 4 patients received fixed prostheses. RESULTS No implants were lost, and few surgical complications were experienced. The follow-up period was 11 to 49 months. DISCUSSION Although surgical problems precipitated by difficult anatomy in cleft patients and a patient with reduced interarch access were experienced, the results were favorable. Fabricating a functional and esthetic prosthesis can be a challenge. CONCLUSION Zygomatic implants provide a treatment option for patients with severe maxillary resorption, defects, or situations where previous implant treatment has failed. In this experience, treatment with zygomatic implants was a predictable method with few complications, even in a group of patients that would not be considered ideal for implant treatment.
Exclusive Breastfeeding, Diarrhoeal Morbidity and All-Cause Mortality in Infants of HIV-Infected and HIV Uninfected Mothers: An Intervention Cohort Study in KwaZulu Natal, South Africa

Introduction Antiretroviral drug interventions significantly reduce the risk of HIV transmission to infants through breastfeeding. We report diarrhoea prevalence and all-cause mortality at 12 months of age according to infant feeding practices, among infants born to HIV-infected and uninfected mothers in South Africa. Methods A non-randomised intervention cohort study that followed both HIV-infected and HIV-uninfected mothers and their infants until 18 months of age. Mothers were supported in their infant feeding choice. Detailed morbidity and vital status data were collected over the first year. At the time, only single dose nevirapine was available to prevent mother-to-child transmission of HIV. Results Among 2,589 infants, detailed feeding data and vital status were available for 1,082 HIV-exposed infants and 1,155 HIV non-exposed infants. Among exclusively breastfed (EBF) infants there were 9.4 diarrhoeal days per 1,000 child days (95%CI. 9.12-9.82) while among infants who were never breastfed there were 15.6 diarrhoeal days per 1,000 child days (95%CI. 14.62-16.59). Exclusive breastfeeding was associated with fewer acute, persistent and total diarrhoeal events than mixed or no breastfeeding in both HIV-exposed infants and also infants of HIV uninfected mothers. In an adjusted cox regression analysis, the risk of death among all infants by 12 months of age was significantly greater in those who were never breastfed (aHR 3.5, p<0.001) or mixed fed (aHR 2.65, p<0.001) compared with those who were EBF. In separate multivariable analyses, infants who were EBF for shorter durations had an increased risk of death compared to those EBF for 5-6 months [aHR 2.18 (95% CI, 1.56-3.01); p<0.001]. Discussion In the context of antiretroviral drugs being scaled-up to eliminate new HIV infections among children, there is strong justification for financial and human resource investment to promote and support exclusive breastfeeding to improve HIV-free survival of HIV-exposed and non-exposed infants.