Miracle-dz/UniFAR-FTUs huggingface dataset:
Tragedy into policy: a quantitative study of nurses' attitudes toward patient advocacy activities.

BACKGROUND In 2007 and 2008, 115 patients were found to be either certainly or presumptively infected with the hepatitis C virus through the reuse of contaminated medication vials at two southern Nevada endoscopy clinics. A subsequent joint investigation by federal and state agencies found multiple breaches of infection control protocols. There was also strong anecdotal evidence that among clinic staff, unsafe patient care conditions often went unreported because of a general fear of retaliation. At the request of the Nevada legislature's Legislative Committee on Health Care, a study was conducted to examine Nevada RNs' experiences with workplace attitudes toward patient advocacy activities. This article presents the study findings and reviews how one public health tragedy led to the creation of effective health care policy. METHODS A study questionnaire was developed and tested for reliability and validity. Questionnaires were then sent to an initial sample of 1,725 Nevada RNs, representing 10% of all RNs in the Nevada State Board of Nursing database with active licenses and current Nevada addresses. RESULTS The response rate was modest at 33% (564 respondents). Of those who responded, 34% indicated that they'd been aware of a patient care condition that could have caused harm to a patient, yet hadn't reported it. The most common reasons given for nonreporting included fears of workplace retaliation (44%) and a belief that nothing would come of reports that were made (38%). CONCLUSIONS The study findings underscore the need for a shift in organizational culture toward one that encourages clear and open communication when patient safety may be in jeopardy. These findings were ultimately used to support the passage of whistleblower protection legislation in Nevada. KEYWORDS Las Vegas hepatitis C outbreak, patient advocacy, whistleblower.
Comparison of two MR sequences for the detection of multiple sclerosis lesions in the spinal cord.

PURPOSE To compare cardiac-triggered dual-echo spin-echo and magnetization transfer-prepared gradient-echo (MT-GE) MR imaging in the detection of multiple sclerosis (MS) lesions in the spinal cord. METHODS The cervical spinal cord in 20 patients with MS and in nine healthy volunteers was examined with spin-echo and MT-GE MR imaging. Sagittal images were scored for number of lesions, certainty about lesions, image quality, and visual hindrance by artifacts in random order by two radiologists separately and in a blinded manner. RESULTS In one healthy volunteer, a lesion was seen on images obtained with both images. Lesion/cord contrast-to-noise ratio was equal on both the MT-GE and T2-weighted spin-echo images. MT-GE images showed better image quality and fewer artifacts than the spin-echo images did. The readers found approximately the same number of lesions. However, the number of definite lesions was higher for the spin-echo sequence than for the MT-GE sequence. One reader found 45 definite lesions with spin-echo and 34 definite lesions with MT-GE. For the other reader, these numbers were 37 (spin-echo) and 31 (MT-GE). On the spin-echo images, 90% of the patients were considered to have definite lesions; on the MT-GE images, the readers found definite lesions in 65% (reader 1) and in 70% (reader 2) of the patients. CONCLUSION Image quality was better with the MT-GE technique than with the spin-echo technique, and lesion/cord contrast-to-noise ratio on the MT-GE images was equal to that of T2-weighted spin-echo images. However, for detecting spinal cord MS lesions in the sagittal plane, the spin-echo images were preferred to the MT-GE images.
Power Management for Energy Systems

Considerable amounts of energy are consumed in supermarket refrigeration systems worldwide. Due to the thermal capacity of refrigerated goods and the rather simplistic control most commonly applied, there is a potential for distributing the system load over time in a more cost-optimal way. In this paper we describe a novel economic-optimizing Model Predictive Control (MPC) scheme that reduces operating costs by utilizing the thermal storage capabilities. A nonlinear optimization tool to handle a nonconvex cost function is utilized for simulations with validated scenarios. In this way we explicitly address advantages from daily variations in outdoor temperature and electricity prices. Secondly, we formulate a new cost function that enables the refrigeration system to contribute with ancillary services to the balancing power market. This involvement can be economically beneficial for the system itself, while crucial services can be delivered to a future flexible and intelligent power grid (Smart Grid). Furthermore, we discuss a novel incorporation of probabilistic constraints and Second Order Cone Programming (SOCP) with economic MPC. A Finite Impulse Response (FIR) formulation of the system models allows us to describe and handle model as well as prediction uncertainties in this framework. This means we can demonstrate means for robustifying the performance of the controller. 2011 Elsevier Ltd. All rights reserved.
Ulcerative colitis and Crohn's disease

In the past four years three excellent and comprehensive books on inflammatory bowel disease have been published. *RF 1-3* In a total of 1812 pages 156 contributors provide detailed accounts of the recent striking rise in the incidence of Crohn's disease but not ulcerative colitis in most developed countries; patients' genetic disposition (the dis-eases are apparently not HLA related); and clinical features, immunology, pathology, complications, and management options. Can there be much left to find out? Regrettably for the 120 000 or so patients with inflammatory bowel disease in Britain, from toddlers to octogenarians, the answer is yes. And despite inflam-matory bowel disease being unfashionable and attracting little research funding, there is a wealth of research going on. Theories of the cause of inflammatory bowel disease abound. Current front runners include a range of types of immune dysregulation, such as abnormally vigorous stimulation of the gut immune system by products of the commensal flora, inappropriate activation of a single component among the many gut immune cells and mediators, or failure of an inhibitory signal that normally switches off a protective local inflammatory reaction. …
Spinal cord quantitative MRI discriminates between disability levels in multiple sclerosis

Objective: The clinicoradiologic paradox, or disconnect between clinical and radiologic findings, is frequently encountered in multiple sclerosis (MS), particularly in the spinal cord (SC), where lesions are expected to cause clinical impairment. We aimed to assess whether quantitative diffusion tensor and magnetization transfer imaging measures in the SC can distinguish MS cases of comparable lesion burdens with high and low disability. Methods: One hundred twenty-four patients with MS underwent 3-T cervical SC MRI and were categorized into 4 subgroups according to SC lesion count and disability level. Regions of interest circumscribed the SC cross-section axially between C3 and C4. Cross-sectional area, fractional anisotropy (FA), mean diffusivity (MD), perpendicular diffusivity (λ⊥), parallel diffusivity (λ‖), and magnetization transfer ratio (MTR) were calculated. Differences between patient subgroups were assessed using t tests and linear regression. Results: FA, MD, λ⊥, λ‖, MTR, and SC cross-sectional area were more abnormal in the high- vs low-disability subgroup of patients with low lesion counts (p < 0.05). MRI measures (except λ‖ and MTR) were more abnormal in the high- vs low-disability subgroup of patients with high lesion counts (p < 0.05). In age- and sex-adjusted comparisons of high- vs low-disability subgroups, all MRI measures retained differences in the low-lesion subgroup, except λ‖, whereas only FA, MD, and λ⊥ retained differences in the high-lesion subgroup. Conclusions: In this cross-sectional study of patients with MS, quantitative MRI reflects clinically relevant differences beyond what can be detected by conventional MRI. Our findings support the utility of quantitative MRI in clinical settings, where accurate measurement of disease burden is becoming increasingly critical for assessing treatment efficacy.
Fast Evolution from Precast Bricks: Genomics of Young Freshwater Populations of Threespine Stickleback Gasterosteus aculeatus

Adaptation is driven by natural selection; however, many adaptations are caused by weak selection acting over large timescales, complicating its study. Therefore, it is rarely possible to study selection comprehensively in natural environments. The threespine stickleback (Gasterosteus aculeatus) is a well-studied model organism with a short generation time, small genome size, and many genetic and genomic tools available. Within this originally marine species, populations have recurrently adapted to freshwater all over its range. This evolution involved extensive parallelism: pre-existing alleles that adapt sticklebacks to freshwater habitats, but are also present at low frequencies in marine populations, have been recruited repeatedly. While a number of genomic regions responsible for this adaptation have been identified, the details of selection remain poorly understood. Using whole-genome resequencing, we compare pooled genomic samples from marine and freshwater populations of the White Sea basin, and identify 19 short genomic regions that are highly divergent between them, including three known inversions. 17 of these regions overlap protein-coding genes, including a number of genes with predicted functions that are relevant for adaptation to the freshwater environment. We then analyze four additional independently derived young freshwater populations of known ages, two natural and two artificially established, and use the observed shifts of allelic frequencies to estimate the strength of positive selection. Adaptation turns out to be quite rapid, indicating strong selection acting simultaneously at multiple regions of the genome, with selection coefficients of up to 0.27. High divergence between marine and freshwater genotypes, lack of reduction in polymorphism in regions responsible for adaptation, and high frequencies of freshwater alleles observed even in young freshwater populations are all consistent with rapid assembly of G. aculeatus freshwater genotypes from pre-existing genomic regions of adaptive variation, with strong selection that favors this assembly acting simultaneously at multiple loci.
Prenatal and Postnatal Serum PCB Concentrations and Cochlear Function in Children at 45 Months of Age

Background: Some experimental and human data suggest that exposure to polychlorinated biphenyls (PCBs) may induce ototoxicity, though results of previous epidemiologic studies are mixed and generally focus on either prenatal or postnatal PCB concentrations exclusively. Objectives: Our aim was to evaluate the association between pre- and postnatal PCB concentrations in relation to cochlear status, assessed by distortion product otoacoustic emissions (DPOAEs), and to further clarify the critical periods in development where cochlear status may be most susceptible to PCBs. Methods: A total of 351 children from a birth cohort in eastern Slovakia underwent otoacoustic testing at 45 months of age. Maternal pregnancy, cord, and child 6-, 16-, and 45-month blood samples were collected and analyzed for PCB concentrations. At 45 months of age, DPOAEs were assessed at 11 frequencies in both ears. Multivariate, generalized linear models were used to estimate the associations between PCB concentrations at different ages and DPOAEs, adjusting for potential confounders. Results: Maternal and cord PCB-153 concentrations were not associated with DPOAEs at 45 months. Higher postnatal PCB concentrations at 6-, 16-, and 45-months of age were associated with lower (poorer) DPOAE amplitudes. When all postnatal PCB exposures were considered as an area-under-the-curve metric, an increase in PCB-153 concentration from the 25th to the 75th percentile was associated with a 1.6-dB SPL (sound pressure level) decrease in DPOAE amplitude (95% CI: –2.6, –0.5; p = 0.003). Conclusions: In this study, postnatal rather than maternal or cord PCB concentrations were associated with poorer performance on otoacoustic tests at age 45 months. Citation: Jusko TA, Sisto R, Iosif AM, Moleti A, Wimmerová S, Lancz K, Tihányi J, Šovčíková E, Drobná B, Palkovičová L, Jurečková D, Thevenet-Morrison K, Verner MA, Sonneborn D, Hertz-Picciotto I, Trnovec T. 2014. Prenatal and postnatal serum PCB concentrations and cochlear function in children at 45 months of age. Environ Health Perspect 122:1246–1252; http://dx.doi. org/10.1289/ehp.1307473
Infusion of Brain-Derived Neurotrophic Factor into the Lateral Ventricle of the Adult Rat Leads to New Neurons in the Parenchyma of the Striatum, Septum, Thalamus, and Hypothalamus

The findings that brain-derived neurotrophic factor (BDNF) promotes in vitro the survival and/or differentiation of postnatal subventricular zone (SVZ) progenitor cells and increasesin vivo the number of the newly generated neurons in the adult rostral migratory stream and olfactory bulb prompted us to investigate whether the infusion of BDNF influences the proliferation and/or differentiation of cells in other regions of the adult forebrain. We examined the distribution and phenotype of newly generated cells in the adult rat forebrain 16 d after intraventricular administration of BDNF in conjunction with the cell proliferation marker bromodeoxyuridine (BrdU) for 12 d. BDNF infusion resulted in numerous BrdU+ cells, not only in the SVZ lining the infused lateral ventricle, but moreover, in specific parenchymal structures lining the lateral and third ventricles, including the striatum and septum, as well as the thalamus and hypothalamus, in which neurogenesis had never been demonstrated previously during adulthood. In each region, newly generated cells expressed the neuronal marker microtubule-associated protein-2, or neuron-specific tubulin, identified by the antibody TuJ1. The percentage of the newly generated cells expressing TuJ1 ranged from 27 to 42%, suggesting that the adult forebrain has a more profound capacity to produce neurons than recognized previously. The extent of cell proliferation after BDNF infusion was correlated with the level of expression of full-length TrkB, the high-affinity receptor for BDNF, despite the fact that the BrdU+ cells were not themselves TrkB+. Collectively, our results demonstrate that the adult brain parenchyma may recruit and/or generate new neurons, which could replace those lost as a result of injury or disease.
Performance Analysis of a New Real-Time Elastographic Time Constant Estimator

New elastographic techniques such as poroelastography and viscoelasticity imaging aim at imaging the temporal mechanical behavior of tissues. These techniques usually involve the use of curve fitting methods being applied to noisy data to estimate new elastographic parameters. As of today, however, current elastographic implementations of poroelastography and viscoelasticity imaging methods are in general too slow and not optimized for clinical applications. Furthermore, image quality performance of these new elastographic techniques is still largely unknown due to a paucity of data and the lack of systematic studies that analyze their performance limitations. In this paper, we propose a new elastographic time constant (TC) estimator, which is based on the use of the least square error (LSE) curve-fitting method and the Levenberg-Marquardt (LM) optimization rule as applied to noisy elastographic data obtained from a material in a creep-type experiment. The algorithm is executed on a massively parallel general purpose graphics processing unit (GPGPU) to achieve real-time performance. The estimator's performance is analyzed using simulations. Experimental results obtained from poroelastic phantoms are presented as a proof of principle of the new estimator's technical applicability on real experimental data. The results of this study demonstrate that the newly proposed elastographic estimator can produce highly accurate and sensitive elastographic TC estimates in real-time and at high signal-to-noise ratios.
Lipid and lipoprotein levels in children with malaria parasitaemia

It is a common advice in the eastern region of Nigeria that anyone with high fever suspected to be malaria should not take much fatty meal. There is not yet definite biochemical reason for this. We assessed lipid profiles of twenty (20) children, aged between one and twelve years, suffering from malaria. Another fifteen (15) age-matched, uninfected children, were used as controls. Our parameters included total cholesterol, high density lipoprotein (HDL), low density lipoprotein (LDL), very low density lipoprotein (VLDL) and triglyceride. Pa-tients were later classified according to the severity of the infection represented by the den-sity of malaria parasites seen per high field of thick film. Our results showed that these lipo-proteins significantly decreased (p<0.05) in the patients than in the control group. However there was no correlation between the malaria density and the levels of these lipoproteins. We suggest that mild fatty nutrients should be recommended to this class of patients for effec-tive stability and prevention of weight loss during the treatment, bearing in mind that they are not even at risk of any condition caused by hyperlipidaemia.
Age-dependent allocation of carotenoids to coloration versus antioxidant defences

SUMMARY Aging is commonly attributed to age-related changes in oxidative damage due to an increased production of reactive oxygen species (ROS) and a weakened efficacy of enzymatic antioxidants. These age-related changes might therefore modify the use of dietary antioxidants, including carotenoids. As carotenoids are closely associated with the expression of secondary sexual signals, the allocation of carotenoids to sexual signal versus antioxidant defences may vary with age. In this study, we explored how carotenoid-based ornament and antioxidant activity varied with age and how an inflammatory-induced oxidative burst affected ornament and antioxidant activity across a range of ages. Using zebra finches (Taeniopygia guttata) as a model species, we assessed circulating carotenoids, beak coloration and the plasma antioxidant status of birds of different ages before and after an inflammatory challenge. Our results show that old individuals display similar carotenoid-based sexual signals regardless of the availability of circulating carotenoids, suggesting a terminal investment of old individuals in their last reproductive event. Additionally, we found that an inflammatory insult induced a decrease in the total antioxidant activity and in the expression of a carotenoid-based sexual signal in the oldest individuals. These results suggest that old individuals pay an extra cost of immune activation possibly because the efficiency of antioxidant machinery varies with age.
Barriers to use of modern contraceptives among women in an inner city area of Osogbo metropolis, Osun state, Nigeria

Objectives To determine the knowledge and attitudes on modern contraceptive use of women living in an inner city area of Osogbo. Materials and methods Three hundred and fifty nine women of childbearing age were studied utilizing a community-based, descriptive, cross-sectional study design. A multistage random sampling technique was used in recruiting respondents to the study. A four-part questionnaire was applied dually, by interviewers and by respondents’ self administration, and the data was analyzed using the SPSS software version 17.0. Results The mean age of respondents was 28.6 ± 6.65 years. The majority (90.3%) of respondents were aware of modern methods of family planning (FP), 76.0% claimed awareness of where to obtain FP services, and 74.9% knew of at least five methods. However, only 30.6% had ever used contraceptives, while only 13.1% were current users. The most frequently used method was the male condom. The commonly perceived barriers accounting for low use of FP methods were fear of perceived side effects (44.0%), ignorance (32.6%), misinformation (25.1%), superstition (22.0%), and culture (20.3%). Some reasons were proffered for respondents’ nonuse of modern contraception. Predictors of use of modern contraceptives include the awareness of a place of FP service provision, respondents’ approval of the use of contraceptives, higher education status, and being married. Conclusion Most of the barriers reported appeared preventable and removable and may be responsible for the reported low point prevalence of use of contraceptives. It is recommended that community-based behavioral-change communication programs be instituted, aimed at improving the perceptions of women with respect to bridging knowledge gaps about contraceptive methods and to changing deep-seated negative beliefs related to contraceptive use in Nigeria.
Verification of relational data-centric dynamic systems with external services

Data-centric dynamic systems are systems where both the process controlling the dynamics and the manipulation of data are equally central. We study verification of (first-order) mu-calculus variants over relational data-centric dynamic systems, where data are maintained in a relational database, and the process is described in terms of atomic actions that evolve the database. Action execution may involve calls to external services, thus inserting fresh data into the system. As a result such systems are infinite-state. We show that verification is undecidable in general, and we isolate notable cases where decidability is achieved. Specifically we start by considering service calls that return values deterministically (depending only on passed parameters). We show that in a mu-calculus variant that preserves knowledge of objects appeared along a run we get decidability under the assumption that the fresh data introduced along a run are bounded, though they might not be bounded in the overall system. In fact we tie such a result to a notion related to weak acyclicity studied in data exchange. Then, we move to nondeterministic services and we investigate decidability under the assumption that knowledge of objects is preserved only if they are continuously present. We show that if infinitely many values occur in a run but do not accumulate in the same state, then we get again decidability. We give syntactic conditions to avoid this accumulation through the novel notion of "generate-recall acyclicity", which ensures that every service call activation generates new values that cannot be accumulated indefinitely.
Essential genes for astroglial development and axon pathfinding during zebrafish embryogenesis

The formation of the central nervous system depends on the coordinated development of neural and glial cell types that arise from a common precursor. Using an existing group of zebrafish mutants generated by viral insertion, we performed a “shelf‐screen” to identify genes necessary for astroglial development and axon scaffold formation. We screened 274 of 315 viral insertion lines using antibodies that label axons (anti‐Acetylated Tubulin) and astroglia (anti‐Gfap) and identified 25 mutants with defects in gliogenesis, glial patterning, neurogenesis, and axon guidance. We also identified a novel class of mutants affecting radial glial cell numbers. Defects in astroglial patterning were always associated with axon defects, supporting an important role for axon‐glial interactions during axon scaffold development. The genes disrupted in these viral lines have all been identified, providing a powerful new resource for the study of axon guidance, glio‐ and neurogenesis, and neuron‐glial interactions during development of the vertebrate CNS. Developmental Dynamics 239:2603–2618, 2010. © 2010 Wiley‐Liss, Inc.