Miracle-dz/UniFAR-FTUs huggingface dataset:
Probably Role of Antioxidants Against EMFs-Induced Effects on Central Nervous System Structures: A Mini Review

Electric and magnetic fields (EMFs) are one of the main environmental pollutants inducing adverse effects on life quality. Waves emitted from industrial and domestic equipments always expose humans to the risk of some diseases. The central nervous system (CNS) is one of the structures sensitive to these waves, which could be damaged seriously. Complexity of the neural structure demands more researches based on morphological and histological changes. Important factors involved in EMFs effects on neural function concern the type, frequency, intensity of waves and duration of the exposure. Surely, increased dosage of the electromagnetic waves results in severe consequences on the function of brain neurons. However, antioxidants may prevent chronic injuries via different methods. The critical periods of fetal, childhood, or pregnancy are more susceptible to irreparable risks of electric magnetic waves. There are several strategies to reduce effects of such waves, by using antioxidants, for instance. However, different theories have been presented on their efficiency due to the abundance of antioxidants available in nature. In the present review, we conclude that even low-dosages of EMFs would have negative effects on CNS. According to some previous studies, various dosages of antioxidants have different effects on neural function leading to various theories on this subject. Keywords Author Keywords:Electromagnetic fields; Central nervous system; Antioxidants
Deletion of CDKAL1 Affects Mitochondrial ATP Generation and First-Phase Insulin Exocytosis

Background A variant of the CDKAL1 gene was reported to be associated with type 2 diabetes and reduced insulin release in humans; however, the role of CDKAL1 in β cells is largely unknown. Therefore, to determine the role of CDKAL1 in insulin release from β cells, we studied insulin release profiles in CDKAL1 gene knockout (CDKAL1 KO) mice. Principal Findings Total internal reflection fluorescence imaging of CDKAL1 KO β cells showed that the number of fusion events during first-phase insulin release was reduced. However, there was no significant difference in the number of fusion events during second-phase release or high K+-induced release between WT and KO cells. CDKAL1 deletion resulted in a delayed and slow increase in cytosolic free Ca2+ concentration during high glucose stimulation. Patch-clamp experiments revealed that the responsiveness of ATP-sensitive K+ (KATP) channels to glucose was blunted in KO cells. In addition, glucose-induced ATP generation was impaired. Although CDKAL1 is homologous to cyclin-dependent kinase 5 (CDK5) regulatory subunit-associated protein 1, there was no difference in the kinase activity of CDK5 between WT and CDKAL1 KO islets. Conclusions/Significance We provide the first report describing the function of CDKAL1 in β cells. Our results indicate that CDKAL1 controls first-phase insulin exocytosis in β cells by facilitating ATP generation, KATP channel responsiveness and the subsequent activity of Ca2+ channels through pathways other than CDK5-mediated regulation.
Plasma vitamin D and cytokines in periodontal disease and postmenopausal osteoporosis.

BACKGROUND AND OBJECTIVE Osteoporosis and periodontal disease are chronic diseases, in the pathogenesis of which plasma osteoprotogerin (OPG) and RANKL are important. The study aimed to investigate the relationship between periodontal disease and plasma cytokines, vitamin D and bone mineral density in postmenopausal women with and without osteoporosis. MATERIAL AND METHODS One hundred and eighty-five postmenopausal women with osteoporosis and 185 age- and sex-matched control subjects were recruited. Periodontal disease was subdivided into active or past periodontal disease. Osteoprotegerin, RANKL, 25-hydroxyvitamin D₃ (25OHD), biochemical markers of bone turnover (serum C-terminal telopeptide, CTX), anthropometry and bone mineral density were measured. RESULTS A significantly higher proportion of the women with osteoporosis had active or past periodontal disease or both compared with control subjects (87.6 vs. 37.8%, p < 0.001). Plasma 25OHD was significantly lower (p < 0.001) and RANKL and OPG significantly higher in the women with osteoporosis than in control subjects (p < 0.0001). RANKL, OPG and CTX were significantly higher in women with active periodontal disease than in those without (p < 0.001), as were OPG and CTX in past periodontal disease (p < 0.001). In active and past periodontal disease, 25OHD was significantly lower (p < 0.001). Multiple logistic regression analysis showed that periodontal disease was best predicted by RANKL, 25OHD, C-terminal telopeptide and weight, r² = 10.4%. CONCLUSION Periodontal disease is more common in women with osteoporosis and is associated with lower vitamin D and higher concentrations of RANKL and OPG. Raised cytokines may provide the underlying mechanism that links these two conditions.
Estudo morfométrico do coração fetal: sua utilização como parâmetro para análise ecocardiográfica

OBJECTIVE: To evaluate the diameter, perimeter and area of atrioventricular valves as well thickness of ventricular walls and diameter of ventricular cavity of fetal hearts. MATERIALS AND METHODS: Twenty fetal hearts at gestational age between 28 and 36 weeks were dissected. A paquimeter with 1/10 mm accuracy was utilized for the following morphological measurements: anteroposterior and transverse diameters, mitral and tricuspid valves areas and perimeters. RESULTS: Anteroposterior and transverse diameters of the left atrioventricular valve measured 10.35 ± 1.62 mm and 9.90 ± 1.79 mm, respectively; and anteroposterior and transverse diameters of the right atrioventricular valve measured 10.98 ± 1.90 mm and 9.51 ± 1.81 mm, respectively. Mitral valve area and perimeter were, respectively, 84.06 ± 25.09 mm² and 29.87 ± 3.96 mm. Tricuspid valve area and perimeter were, respectively, 84.49 ± 26.79 mm² and 28.44 ± 3.85 mm. The thicknesses of the anterior and posterior right ventricular walls were, respectively, 5.00 ± 1.70 mm and 3.83 ± 0.91 mm. The thicknesses of the anterior and posterior left ventricular walls were, respectively, 4.25 ±0.87 mm and 4.14 ± 0.89 mm. The thickness of the interventricular septum measured 4.10 ± 1.13 mm. The anteroposterior diameter of the right ventricle was 9.25 ± 0.85 mm, and the transverse diameter was 8.24 ± 0.42 mm. The anteroposterior diameter of the left ventricle measured 9.95 ± 0.37 mm, and transverse diameter measured 9.20 ± 0.40 mm. CONCLUSION: The role of morphometric data of fetal atrioventricular valves is highly significant in the echocardiographic diagnosis of possible congenital cardiac malformations.
User involvement in healthcare technology development and assessment: structured literature review.

PURPOSE Medical device users are one of the principal medical device technology stakeholders. The involvement of users in medical device technology development and assessment is central to meet their needs. This study aims to examine this issue. DESIGN/METHODOLOGY/APPROACH A structured review of the literature published from 1980 to 2005 in peer-reviewed journals was carried out from a social science perspective to investigate user involvement practice in the development and assessment of medical device technologies. This was followed by a qualitative thematic analysis. FINDINGS Medical device users include clinicians, patients, carers and others. Different kinds of medical devices are developed and assessed by user involvement. The user involvement occurs at different stages of the medical device technology lifecycle and the degree of user involvement is in the order of: design > testing and trials > deployment > concept stages. The methods most commonly used for capturing users' perspectives are usability tests, interviews and questionnaire surveys. RESEARCH LIMITATIONS/IMPLICATIONS The relevant engineering, medical and nursing literature, which might have been useful, was not reviewed. However, useful findings emerge that apply to health care generally. ORIGINALITY/VALUE This study shows that medical device users are not homogeneous but heterogeneous in several aspects, such as needs, skills and working environments. This is an important consideration for incorporating users' perspectives in medical device technologies.
AI4AI: Quantitative Methods for Classifying Host Species from Avian Influenza DNA Sequence

Avian Influenza breakouts cause millions of dollars in damage each year globally, especially in Asian countries such as China and South Korea. The impact magnitude of a breakout directly correlates to time required to fully understand the influenza virus, particularly the interspecies pathogenicity. The procedure requires laboratory tests that require resources typically lacking in a breakout emergency. In this study, we propose new quantitative methods utilizing machine learning and deep learning to correctly classify host species given raw DNA sequence data of the influenza virus, and provide probabilities for each classification. The best deep learning models achieve top-1 classification accuracy of 47%, and top-3 classification accuracy of 82%, on a dataset of 11 host species classes.
Isolation of Brucella abortus ssb and uvrA genes from a genomic library by use of lymphocytes as probes

Brucella abortus proteins from virulent S2308 expressed from a pBluescript II SK- genomic library stimulated peripheral blood mononuclear (PBM) cell proliferation from cattle vaccinated with B. abortus S19. The method described here permits a rapid and directed approach to isolate genes encoding antigens of B. abortus that interact with lymphocytes primed to the living bacterium. The supernatants from the bacterial host JM109 (DE3) were cultured with freshly isolated bovine PBM cells. A total of 300 clones were evaluated. Ten clones were identified that stimulated T-lymphocyte proliferation. Among them, one clone with a 2.5-kb insert stimulated T-lymphocyte proliferation in all three animals, suggesting that the proteins encoded by genes within this fragment may represent immunodominant antigens. DNA sequencing of this clone reveals two large open reading frames (ORFs). ORF II has a high degree of similarity to the Escherichia coli ssb gene, which codes for the single-stranded DNA binding protein. ORF I, in the opposite direction to ORF II, shows similarity to the N terminus of the E. coli uvrA gene, which codes for one of the three subunits of the E. coli ABC excision nuclease. The observation that the PBM cells recognized and proliferated in response to proteins expressed from single clones provides a novel strategy to select bacterial antigens that may prove useful in designing alternative vaccines against brucellosis.
Structure theorems for certain Gorenstein ideals

The main achievement of this paper is to provide a structure theorem for Artinian, Gorenstein local rings with the property that the square of the maximal ideal is generated by two elements. The moduli problem for this class of local algebras is also discussed. Finally, upper and lower bounds for the minimal number of generators of perfect ideals are given.
Federal Reserve Bank of Minneapolis Research Department Staff Report 276 Endogenous Policy Choice: the Case of Pollution and Growth

What determines the relationship between pollution and growth? Are the forces that explain the behavior over time of these quantities potentially useful to understand more generally the relationship between policies and growth? In this paper, we make a first attempt to analyze the equilibrium behavior of two quantities—the level of pollution and the level of income—in a setting in which societies choose, via voting, how much to regulate pollution. Our major finding is that, consistent with the evidence, the relationship between pollution and growth need not be monotone and that the precise equilibrium nature of the relationship between the two variables depends on whether individuals vote over effluent charges or directly restrict the choice of technology. Moreover, our analysis of the pollution problem suggests that, more generally, endogenous policy choices should be taken seriously as potential sources of heterogeneity when studying cross country differences in economic performance.mond; the editors and referees for their comments; and the National Science Foundation for financial support. The views expressed herein are those of the authors and not necessarily those of the Federal Reserve Bank of Minneapo-lis or the Federal Reserve System.
Optimizing healthcare research data warehouse design through past COSTAR query analysis

Over the past two years we have reviewed and implemented the specifications for a large relational database (a data warehouse) to find research cohorts from data similar to that contained within the clinical COSTAR database at the Massachusetts General Hospital. A review of 16 years of COSTAR research queries was conducted to determine the most common search strategies. These search strategies are relevant to the general research community, because they use the Medical Query Language (MQL) developed for the COSTAR M database which is extremely flexible (much more so than SQL) and allows searches by coded fields, text reports, and laboratory values in a completely ad hoc fashion. By reviewing these search strategies, we were able to obtain user specifications for a research oriented healthcare data warehouse that could support 90% of the queries. The data warehouse was implemented in a relational database using the star schema, allowing for highly optimized analytical processing. This allowed queries that performed slowly in the M database to be performed very rapidly in the relational database. It also allowed the data warehouse to scale effectively.
One-loop phi-MHV amplitudes using the unitarity bootstrap: the general helicity case

We consider a Higgs boson coupled to gluons via the five-dimensional effective operator HtrGμνGμν. We treat H as the real part of a complex field that couples to the selfdual gluon field strengths and compute the one-loop corrections to the -MHV amplitudes involving , two negative helicity gluons and an arbitrary number of positive helicity gluons. Our results generalise earlier work where the two negative helicity gluons were constrained to be colour adjacent. We use four-dimensional unitarity to construct the cut-containing contributions and the recently developed recursion relations to obtain the rational contribution for an arbitrary number of external gluons. We solve the recursion relations and give explicit results for up to four external gluons. These amplitudes are relevant for Higgs plus jet production via gluon fusion in the limit where the top quark mass is large compared to all other scales in the problem.
Inhibition of androgen receptor and β-catenin activity in prostate cancer

Androgen receptor (AR) is the major therapeutic target in aggressive prostate cancer. However, targeting AR alone can result in drug resistance and disease recurrence. Therefore, simultaneous targeting of multiple pathways could in principle be an effective approach to treating prostate cancer. Here we provide proof-of-concept that a small-molecule inhibitor of nuclear β-catenin activity (called C3) can inhibit both the AR and β-catenin–signaling pathways that are often misregulated in prostate cancer. Treatment with C3 ablated prostate cancer cell growth by disruption of both β-catenin/T-cell factor and β-catenin/AR protein interaction, reflecting the fact that T-cell factor and AR have overlapping binding sites on β-catenin. Given that AR interacts with, and is transcriptionally regulated by β-catenin, C3 treatment also resulted in decreased occupancy of β-catenin on the AR promoter and diminished AR and AR/β-catenin target gene expression. Interestingly, C3 treatment resulted in decreased AR binding to target genes accompanied by decreased recruitment of an AR and β-catenin cofactor, coactivator-associated arginine methyltransferase 1 (CARM1), providing insight into the unrecognized function of β-catenin in prostate cancer. Importantly, C3 inhibited tumor growth in an in vivo xenograft model and blocked renewal of bicalutamide-resistant sphere-forming cells, indicating the therapeutic potential of this approach.
Text entry using soft keyboards

Text entry rates are explored for several variations of soft keyboards. We present a model to predict novice and expert entry rates and present an empirical test with 24 subjects. Six keyboards were examined: the Qwerty, ABC, Dvorak, Fitaly, JustType, and telephone. At 8-10 wpm, novice predictions are low for all layouts because the dominant factor is the visual scan time, rather than the movement time. Expert predictions are in the range of 22-56 wpm, although these were not tested empirically. In a quick, novice test with a representative phrase of text, subjects achieved rates of 20.2 wpm (Qwerty), 10.7 wpm (ABC), 8.5 wpm (Dvorak), 8.0 wpm (Fitaly), 7.0 wpm (JustType), and 8.0 wpm (telephone). The Qwerty rate of 20.2 wpm is consistent with observations in other studies. The relatively high rate for Qwerty suggests that there is skill transfer from users' familiarity with desktop computers to the stylus tapping task.
Applying the balanced scorecard for better performance of intellectual capital

Purpose – One of the responses to criticisms of traditional forms of accounting reports for knowledge‐based firms has been the development of the balanced scorecard (BSC), a strategic performance measurement framework and methodology based on a family of performance measures. This paper aims to examine the issue of measuring performance in relation to a major Australian company, The Fosters Brewing Group, where a newly appointed CEO reversed a decline in performance by adopting, among other initiatives, the balanced scorecard approach to management.Design/methodology/approach – The paper takes the form of a case study, applying the theoretical framework of the BSC to a declining business in order to achieve a turnaround.Findings – The paper discusses how a newly appointed CEO of The Fosters Brewing Group reversed a decline in performance by adopting, among other initiatives, the balanced scorecard approach to management.Research limitations/implications – The BSC is a practical framework to deal with the .
Clinical Characteristics of 2 Groups of Children With Feeding Difficulties

Objectives: The primary aim of this study was to describe and compare the clinical characteristics of 2 groups of children presenting to a feeding clinic: children with autism spectrum disorder (ASD) and children with a nonmedically complex history (NMC). A secondary aim was to compare participants according to the degree of oral motor impairment, presence of oral hypersensitivity, and clinically significant parent stress. Methods: Children with feeding difficulties ages between 2 and 6 years were recruited. Prospective data were collected on dietary intake, general development, mealtime behaviors, oral motor skills, oral sensory processing, and parental stress via parent questionnaire and clinical assessment. Results: In total, 68 children (ASD = 33 and NMC = 35) participated in the study. Both groups presented with a large number of difficult mealtime behaviors. Although stress was elevated in both groups, parents of children in the ASD group reported significantly higher stress levels than those with children in the NMC group (mean difference 27.3 on a percentile scale, 95% confidence interval [CI] 15.5–39.2, P < 0.01). Across both groups, the majority of children presented with mild-to-moderate oral motor impairments (ASD = 28, 85%; NMC = 28, 80%). Children with heightened oral sensory sensitivity consumed significantly fewer unprocessed fruits and vegetables (mean difference 3.3 foods, 95% CI 1.3–5.3, P < 0.01), and their parents reported a significantly greater frequency of difficult mealtime behaviors (mean difference 5.8 behaviors, 95% CI 3.4–8.1, P < 0.01). Conclusions: Features of feeding difficulty presented similarly across the ASD and NMC groups in this study. Oral motor impairment, oral sensory sensitivity, and parental stress should not be overlooked in the management of children with feeding difficulties, regardless of etiology.
Optimized Active Disturbance Rejection Control for DC-DC Buck Converters With Uncertainties Using a Reduced-Order GPI Observer

The output voltage regulation problem of a PWM-based dc-dc buck converter under various sources of uncertainties and disturbances is investigated in this paper via an optimized active disturbance rejection control (ADRC) approach. Aiming to practical implementation, a new reduced-order generalized proportional integral (GPI) observer is first designed to estimate the lumped (possibly time-varying) disturbances within the dc-dc circuit. By integrating the disturbance estimation information raised by the reduced-order GPI observer into the output prediction, an optimized ADRC method is developed to achieve optimized tracking performance even in the presence of disturbances and uncertainties. It is shown that the proposed controller will guarantee the rigorous stability of the closed-loop system, for any bounded uncertainties of the circuit, by appropriately choosing the observer gains and the bandwidth factor. Experimental results illustrate that the proposed control solution is characterized by improved robustness performance against various disturbances and uncertainties compared with traditional ADRC and integral model predictive control (MPC) approaches.
Brane Worlds, the Subanthropic Principle and the Undetectability Conjecture

In the recent article ‘Conflict between anthropic reasoning and observation’ (gr-qc/0303070) Ken D. Olum, using some inflation-based ideas and the anthropic premise that we should be typical among all intelligent observers in the Universe, arrives at the puzzling conclusion that ‘we should find ourselves in a large civilization (of galactic size) where most observers should be, while in fact we do not’. In this note we discuss the intriguing possibility whether we could be in fact immersed in a large civilization without being aware of it. Our conclusion is that this possibility cannot be ruled out provided two conditions are met, that we call the Subanthropic Principle and the Undetectability Conjecture. The Subanthropic Principle states that we are not typical among the intelligent observers from the Universe. Typical civilizations of typical galaxies would be hundreds of thousands, or millions, of years more evolved than ours and, consequently, typical intelligent observers would be orders of magnitude more intelligent than us. The Undetectability Conjecture states that, generically, all advanced civilizations camouflage their planets for security reasons, so that no signal of civilization can be detected by external observers, who would only obtain distorted data for disuasion purposes. These conditions predict also a low probability of success for the SETI project. We also argue that it is brane worlds, and not inflation, what dramatically could aggravate the ‘missing-alien’ problem pointed out first in the fifties by Enrico Fermi.