Miracle-dz/UniFAR-FTUs huggingface dataset:
Detection of bacterial vaginosis in wet mount, Papanicolaou stained vaginal smears and in Gram stained smears

In a prospective study of 107 women, bacterial vaginosis was clinically diagnosed in 34 women. Compared with clinical diagnosis of bacterial vaginosis, detection of clue cells in Papanicolaou stained vaginal smears showed a sensitivity of 88.2%, a specificity of 98.6%, a positive predictive value of 96.8% and a negative predictive value of 94.7%. The corresponding values for detection of bacterial vaginosis in Gram stained smears compared with the clinical diagnosis were 100%, 97.3%, 94.4% and 100%, respectively. Compared with clue cells in wet smears, identification of clue cells in Papanicolaou stained vaginal smears showed a Kappa index of 0.87 and compared with Gram stain criteria a Kappa index of 0.94. The correlation between Gram stain and Papanicolaou stained vaginal smears showed a Kappa index of 0.89. In contrast to the results of earlier investigators our studies indicate that the demonstration of clue cells in Papanicolaou stained vaginal smears correlate reasonably well with the conventional clinical criteria. However, the Gram stain method may be more reliable than the Papanicolaou method.
X-Ray Cluster Associated with the z = 1.063 CSS Quasar 3C 186: The Jet is Not Frustrated

We report the Chandra discovery of an X-ray cluster at redshift z = 1.063 associated with the compact steep spectrum (CSS) radio-loud quasar 3C 186 (Q0740+380). Diffuse X-ray emission is detected out to ~120 kpc from the quasar and contains 741 ± 40 net counts. The X-ray spectrum of the extended emission shows strong Fe-line emission (EW = 412 eV) at the quasar redshift and confirms the thermal nature of this diffuse component. We measure a cluster temperature of 5.2 keV and an X-ray luminosity LX(0.5-2 keV) ~ 6 × 1044 ergs s-1, which are in agreement with the luminosity-temperature relation for high-redshift clusters. This is the first detection of a bright X-ray cluster around a luminous (Lbol ~ 1047 ergs s-1) CSS quasar at high redshift and is only the fifth z > 1 X-ray cluster detected. We find that the CSS radio source is highly overpressured with respect to the thermal cluster medium by about 3 orders of magnitude. This provides direct observational evidence that the radio source is not thermally confined as posited in the "frustrated" scenario for CSS sources. Instead, it appears that the radio source may be young and we are observing it at an early stage of its evolution. In that case the radio source could supply the energy into the cluster and potentially prevent its cooling.
Polymorphisms at the microRNA binding‐site of the stem cell marker gene CD133 modify susceptibility to and survival of gastric cancer

CD133 is one of the most common stem cell markers, and functional single nucleotide polymorphisms (SNPs) of CD133 may modulate its gene functions and thus cancer risk and patient survival. We hypothesized that potentially functional CD133 SNPs are associated with gastric cancer (GC) risk and survival. To test this hypothesis, we conducted a case‐control study of 371 GC patients and 313 cancer‐free controls frequency‐matched by age, sex, and ethnicity. We genotyped four selected, potentially functional CD133 SNPs (rs2240688A>C, rs7686732C>G, rs10022537T>A, and rs3130C>T) and used logistic regression analysis for associations of these SNPs with GC risk and Cox hazards regression analysis for survival. We found that compared with the miRNA binding site rs2240688 AA genotype, AC + CC genotypes were associated with significantly increased GC risk (adjusted OR = 1.52, 95% CI = 1.09–2.13); for another miRNA binding site rs3130C>T SNP, the TT genotype was associated with significantly reduced GC risk (adjusted OR = 0.68, 95% CI = 0.48–0.97), compared with CC + CT genotypes. In all patients, the risk rs3130 TT variant genotype was significantly associated with overall survival (OS) (adjusted Ptrend = 0.016 and 0.007 under additive and recessive models, respectively). These findings suggest that these two CD133 miRNA binding site variants, rs2240688 and rs3130, may be potential biomarkers for genetic susceptibility to GC and possible predictors for survival in GC patients but require further validation by larger studies. © 2013 Wiley Periodicals, Inc.
Damping Prediction Technique of the Bolted Joint Structure Considering Pretension Force

At the initial phase of the mechanical product development, it is very important to effectively obtain the modal damping ratio of the bolted joint structure for accurately predicting dynamic response. The energy dissipation has been es- timated using a finite element model incorporating the effect of pretension force of the bolted joint. First, the modal damp- ing ratios of the first four modes are extracted by experimental method. Secondly, the lap joint finite element model with pretension force parameter is constructed and based on which, modal analysis of the structure is conducted. The modal shape scaling results are used as the boundary conditions of the finite element model and the energy dissipations and mo- dal damping ratios of the lap joint under different pretension forces are calculated out. By comparing the numerical calcu- lation result and the experimental result, the validation of the damping prediction approach proposed in this paper is proved.
Total Graph Interpretation of the Numbers of the Fibonacci Type

We give a total graph interpretation of the numbers of the Fibonacci type. This graph interpretation relates to an edge colouring by monochromatic paths in graphs. We will show that it works for almost all numbers of the Fibonacci type. Moreover, we give the lower bound and the upper bound for the number of all -edge colourings in trees.
Blood cholesterol and uric acid of healthy medical students under the stress of an examination.

The examination of medical students at the end of their course of studies offers an opportunity to investigate physiological changes occurring in an emotionally stressful situation in healthy persons. Under such and similar circumstances eosinopenia1-4and accelerated coagulation5,6have been demonstrated. On close study of the life histories of a number of patients with coronary occlusion it has been found that mounting emotional stress frequently preceded such an event7,8; it was in a number of instances complicated by an acute additional stressful experience close to the occurrence of cardiac infarction. The similarity of this sequence of events with the situation of preexamination tension terminating in the stress of the examination itself prompted us to study the level of blood cholesterol and its fractions bound to α- and β-lipoprotein under these circumstances. Since a number of patients with coronary artery disease exhibit hyperuricemia, and since stress and corticotropin
BagBoo: a scalable hybrid bagging-the-boosting model

In this paper, we introduce a novel machine learning approach for regression based on the idea of combining bagging and boosting that we call BagBoo. Our BagBoo model borrows its high accuracy potential from. Friedman's gradient boosting [2], and high efficiency and scalability through parallelism from Breiman's bagging [1]. We run empirical evaluations on large scale Web ranking data, and demonstrate that BagBoo is not only showing superior relevance than standalone bagging or boosting, but also outperforms most previously published results on these data sets. We also emphasize that BagBoo is intrinsically scalable and parallelizable, allowing us to train order of half a million trees on 200 nodes in 2 hours CPU time and beat all of the competitors in the Internet Mathematics relevance competition sponsored by Yandex and be one of the top algorithms in both tracks of Yahoo ICML-2010 challenge. We conclude the paper by stating that while impressive experimental evaluation results are presented here in the context of regression trees, the hybrid BagBoo model is applicable to other domains, such as classification, and base training models.
Expression of Calnexin Reflects Paneth Cell Differentiation and Function

It has been suggested that the behavior and function of Paneth cells in metaplasia are different from those found in normal intestinal mucosa. In this study, we investigated whether calnexin, a protein involved in secretory pathways, might be associated with differentiation and function of Paneth cells in normal small intestine, in complete intestinal metaplasia of the stomach, and in Paneth cell–rich adenomas. Differentiation and function of Paneth cells was monitored by Ki67, lysozyme, and morphologic features. Using a newly established monoclonal antibody, we found that calnexin is regularly synthesized by Paneth cells of normal small intestine. In these cells, the staining intensity of calnexin was inversely correlated with their content of secretory granules (lysozyme). In contrast, Paneth cells of intestinal metaplasia and Paneth cell–rich adenomas showed a reduced immunostaining of both calnexin and lysozyme. Moreover, these Paneth cells synthesized the proliferation marker Ki67, a phenomenon that was never observed in Paneth cells of normal small intestine. In vitro experiments using CaCo2 cells showed that the expression of calnexin is not directly affected by the induction of mitosis. In conclusion, calnexin probably reflects the status of Paneth cell differentiation and function. The results do not necessarily indicate that calnexin has a function in Paneth cell proliferation.
Age, Gender and Disorder Related Personality Characteristics of Pediatric Patients Measured by Eysenck Personality Questionnaire -

The study of personality is important not only for psychology and related disciplines, but also in clinical practice. The starting point in this article is Eysenck theory of personality, based primarily on genetics and physiology which corresponds to the temperament. Main categories of temperament for Eysenck are extroversion vs. introversion, neuroticism vs. stability and psychoticism vs.socialisation. In this article, we tried to analyze personality characteristics of eight groups of children and adolescents applying Eysenck Personality Questionnaire (EPQ). EPQ is a 90-item scale for assessing personality in children and adolescents yielding four scales: extroversion (E), Neuroticism (N), Psychoticism (P) and Socialization/Lie scale (L). The examined sample comprised: a) group with mental anorexia; b) group with rheumatoid arthritis; c) patients with cystic fibrosis; d) neurotic patients; e) patients with tension type headache; f) patients with malignancies (leukemia or solid tumors); g) children with psychosomatic problems; f) 10 boys with ticks and h) healthy children, as a control group. Total number of examinees was N = 216 (90 girls, 126 boys). It was shown that EPQ is good choice for differentiation of the main personality traits in children which help in the assessment procedure measuring extroversion, neurotic and psychopathologic traits which is useful for planning treatment options.naire.
Seismology of the base of the solar convection zone

The base of the solar convection zone is a region of transition not just for the temperature gradient, but also for the internal rotation of the Sun. The discontinuity in the derivatives of the sound speed at the base of the overshoot layer below the solar convection zone (CZ) introduces a characteristic oscillatory component in the frequencies of solar p modes as a function of the radial order n. The amplitude of this signal can be calibrated using a sequence of solar models constructed with varying extent of overshoot below the CZ base. Using observed solar oscillation frequencies, we find an improved upper limit of 0.05Hp on the extent of overshoot. This technique also allows us to probe the composition profile at the CZ base, and we find that solar models with a sharp change in the composition gradients at the base of the CZ are ruled out from this study. It thus appears that there is some turbulent mixing just below the base of the CZ. The base of the CZ is also the region where the solar rotation rate changes from differential rotation in the CZ to nearly solid-body rotation in the radiative interior. Using modes that have their lower turning points near the transition region, we show that this transition occurs below the CZ base at a radial distance of 0.7050 ± 0.0027 R0 over a half width of 0.0098 ± 0.0026 R0 . We also find an upper limit of 0.3 MG on the toroidal magnetic field concentrated below the CZ base.
Acute-phase proteins, oxidative stress and enzyme activities of blood serum and peritoneal fluid in cattle with abomasal displacement.

BACKGROUND Blood serum and peritoneal fluid acute-phase proteins, oxidative stress indicators, and some enzymes could be used for evaluation of abomasal tissue damage because of displacement in displaced abomasum (DA) cases. OBJECTIVES The aim of this study was to investigate the concentrations of acute-phase proteins, oxidative stress indicators, and activities of enzymes in blood serum and peritoneal fluid in cattle with right displaced abomasum (RDA) and left displaced abomasum (LDA) and in healthy cows. ANIMALS A total of 60 Holstein Friesian cows in early lactation were used, 31 with left and 9 with right displaced abomasum without volvulus diagnosis and no other postpartum disease, and 20 healthy cows as a control. MATERIALS AND METHODS DA diagnosis in dairy cows consisted of physical examination, laboratory, and specific DA tests. Acute-phase proteins, oxidative stress indicators, and enzyme activities were measured in blood serum and peritoneal fluid. RESULTS In the RDA group, serum haptoglobin (HPG), serum amyloid A (SAA), malondialdehyde (MDA), adenosine deaminase (ADA), myeleperoxidase (MPO), aspartate aminotransferase (AST), creatine kinase (CK, creatine kinase-MB (CK-MB), and gamma-glutamyl transferase (GGT) activity increased significantly, and serum HPG, MDA, ADA, and AST concentrations increased significantly in the LDA group (P < .05). Peritoneal fluid HPG, MDA, ADA, MPO, ALP, GGT, and LDH concentrations increased significantly, whereas NO concentrations reduced significantly in the RDA group, and HPG, MDA, ADA, and TP concentrations increased significantly, whereas concentrations of NO reduced significantly in the LDA group (P < .05). CONCLUSIONS AND CLINICAL IMPORTANCE There are acute-phase responses, oxidative stress, and abomasal tissue damage because of displacement in DA cases. Especially, HPG, MDA, ADA, and MPO concentrations can provide specific information to help in understanding these changes.
Phylattrin, a New Cytotoxic Xanthone from Calophyllum soulattri

Our continuing studies on secondary metabolites from the stem bark of Calophyllum soulattri has led to the isolation of another new diprenylated xanthone, phylattrin (1), in addition to five other xanthones and two common sterols. The xanthones are soulattrin (2), caloxanthone C (3), macluraxanthone (4), brasixanthone B (5) and trapezifolixanthone (6) while the sterols are stigmasterol (7) and β-sitosterol (8). The structures of these compounds were determined on the basis of spectroscopic analyses such as 1D and 2D-NMR, HRESIMS, IR and UV. Compounds 1–7 exhibited moderate cytotoxic activities against SNU-1, HeLa, Hep G2, NCI-H23, K562, Raji, LS174T, IMR-32 and SK-MEL-28 cells.
Effect Personality Matching on Robot Acceptance 1 Effect of Robot-user Personality Matching on the Acceptance of Domestic Assistant Robots for Elderly Effect Personality Matching on Robot Acceptance 2

Lack of acceptance of social assistive robots by elderly could obstruct this technology to bridge the gap between demand and supply of elderly care. Two experiments were conducted with 22 older adults (63 to 87 years old) in a home-like room of the Experience-Lab of Philips. The aim of the first experiment was to test the effect of user-robot personality matching on the acceptance by elderly of a robot that provides agenda and medication reminders. The second experiment explored the mechanism behind robot personality preferences. The results of the first experiment show that the perceived sociability was significantly higher for the extravert robot compared to the introvert robot(p<.05). Sociability is the most prominent characteristic of extraverted people (Tapus & Matari, 2008). Therefore, we concluded that the designed personalities were recognized. In line with previous studies we found that the feeling of social presence (p<.05) and the perceived enjoyability (p<.01) were higher for the extravert robot compared to the introvert robot. Contrary to our expectations, results indicated marginally significant more anxiety for the robot with a similar extraversion level compared to a robot with a complementary extraversion level. On the other hand, the results of our second experiment indicate that similarity attraction influenced the preferred personality of participants. The reasons that participants provided for their robot personality preference suggest that the role that participants believe the robot should have (e.g. a companion or a service oriented machine) and the appreciation of expressed self-confidence influenced their robot personality preferences. The appreciation of expressed self-confidence seems to be related to similarity attraction.
Association between Estrogen Receptor α Gene (ESR1) PvuII (C/T) and XbaI (A/G) Polymorphisms and Hip Fracture Risk: Evidence from a Meta-Analysis

Background and Objective Genetic factors are important in the pathogenesis of fractures. Notably, estrogen receptor α (ESR1) has been suggested as a possible candidate gene for hip fractures; however, published studies of ESR1 gene polymorphisms have been hampered by small sample sizes and inconclusive or ambiguous results. The aim of this meta-analysis is to investigate the associations between two novel common ESR1 polymorphisms (intron 1 polymorphisms PvuII-rs2234693: C>T and XbaI-rs9340799: A>G) and hip fracture. Methods Crude odds ratios (ORs) with 95% confidence intervals (CIs) were used to evaluate the strength of the association. Results Five case-control and three cohort studies were assessed, including a total of 1,838 hip fracture cases and 14,972 healthy controls. This meta-analysis revealed that the PvuII T allele is a highly significant risk factor for hip fracture susceptibility, with an effect magnitude similar in male and pre-menopausal and post-menopausal female patients. In stratified analysis based on ethnicity, the PvuII T allele remained significantly correlated with increased risk of hip fracture in Caucasian populations; this correlation, however, was not found in Asian populations. Unlike the PvuII polymorphism, we did not find significant differences in the XbaI (A>G) polymorphism allele or genotype distributions of hip fracture patients and controls. We also found no obvious association between the XbaI polymorphism and hip fracture in any of the racial or gender subgroups. Conclusion Our findings show that the ESR1 PvuII T allele may increase the risk of hip fracture and that the XbaI polymorphism is not associated with hip fracture.
Gender Differences in Domain-Specific Self-Esteem:

This meta-analysis examines gender differences in 10 specific domains of self-esteem across 115 studies, including 428 effect sizes and 32,486 individuals. In a mixed-effects analysis, men scored significantly higher than women on physical appearance (d 0.35), athletic (d 0.41), personal self (d 0.28), and self-satisfaction self-esteem (d 0.33). Women scored higher than men on behavioral conduct (d 0.17) and moral‐ethical self-esteem (d 0.38). The gender difference in physical appearance self-esteem was significant only after 1980 and was largest among adults. No significant gender differences appeared in academic, social acceptance, family, and affect self-esteem. The results demonstrate the influence of reflected appraisals on self-esteem.
Channel signal-to-noise ratio constrained feedback control: performance and robustness

The limitations in performance and robustness imposed by explicitly considering a communication channel in a control loop have received increased attention in recent years. Previous results in the literature have stated these limitations in terms of a minimal transmission data rate necessary for stabilisation. In this paper a signal-to-noise ratio (SNR) approach is used to study two specific cases: (i) performance in terms of model matching and (ii) robustness against a multiplicative uncertainty in the plant model. The analysis performed leads to closed-form expressions that allow the quantification of the extra SNR required in both cases.
Estimating Markov model structures

The author investigates the derivation of Markov model structures from text corpora. The structure of a Markov model is its number of states plus the set of outputs and transitions with non-zero probability. The domain of the investigated models is part-of-speech tagging. The investigations concern two methods to derive Markov models and their structures. Both are able to form categories and allow words to belong to more than one of them. The first method is model merging, which starts with a large and corpus-specific model and successively merges states to generate smaller and more general models. The second method is model splitting, which is the inverse procedure and starts with a small and general model. States are successively split to generate larger and more specific models. In an experiment, the author shows that the combination of these techniques yields tagging accuracies that are at least equivalent to those of standard approaches.
Dynamic relocation of the TORC1–Gtr1/2–Ego1/2/3 complex is regulated by Gtr1 and Gtr2

Ego2 is characterized as a new subunit of Ego protein complex (the yeast Ragulaor counterpart) that is a scaffold of Gtr (the yeast Rag counterpart) and TORC1. Gtr1 and Gtr2 regulate the dynamic translocation of the Ego/Gtr/TORC1 supercomplex between the vacuolar limiting membrane and perivacuolar foci. This localization shift is closely associated with the TORC1 activity level.
Prognostic significance of p27Kip1, p45Skp2 and Ki67 expression profiles in Merkel cell carcinoma, extracutaneous small cell carcinoma, and cutaneous squamous cell carcinoma

Aims: To compare the immunohistochemical expression of prognostic markers p27Kip1, p45Skp2 and Ki67 in Merkel cell carcinoma (primary neuroendocrine carcinoma of the skin, MCC), small cell neuroendocrine carcinoma of lung and urinary bladder (SNC), and cutaneous squamous cell carcinoma (SCC).
Contributions of lipids and proteins to the surface charge of membranes. An electron microscopy study with cationized and anionized ferritin

The surface charge of cultured neurons was investigated with the electron microscope markers anionized ferritin (AF) and cationized ferritin (CF). To determine which membrane components could react with the markers, model reactions were used. Both protein-coated Sepharose beads and lipid vesicles were reacted at physiological pH. Results with these model reactions indicate that the following groups may contribute to the surface charge: acidic groups--the sialic acid of both glycoproteins and gangliosides, the carboxyl group of proteins, and the phosphates of phospholipids; basic groups--the amines of proteins. The effect of chemical fixation on the surface charge was investigated. Glutaraldehyde fixation was shown to increase the charge of neutral proteins but not by a mechanism involving unbound aldehydes. Glutaraldehyde fixation of phospholipid vesicles in the presence of CF showed that amine-containing phospholipids were cross-linked to CF. This cross-linkage was seen with the electron microscope as the clumping of CF and the burying of CF in the membrane. Paraformaldehyde fixation had a lesser effect on the charge of proteins but did react with phospholipids as did glutaraldehyde. It is concluded that at physiological pH: (a) most of the charged proteins and lipids on cell surface can contribute to the membrane surface charge, and (b) the membrane surface charge of cells can be greatly changed by chemical fixation.