Miracle-dz/UniFAR-FTUs huggingface dataset:
Infant pitch perception: evidence for responding to pitch categories and the missing fundamental.

While numerous studies on infant perception have demonstrated the infant's ability to discriminate sounds having different frequencies, little research has evaluated more sophisticated pitch perception abilities such as perceptual constancy and perception of the missing fundamental. In the present study 7-8-month-old infants demonstrated the ability to discriminate harmonic complexes from two pitch categories that differed in pitch by approximately 20% (e.g., 160 vs 200 Hz). Using a visually reinforced conditioned head-turning paradigm, a number of spectrally different tonal complexes that contained varying harmonic components but signaled the same two pitch categories were presented. After learning the basic pitch discrimination, the same infants learned to categorize spectrally different tonal complexes according to the pitches signaled by their fundamental frequencies. That is, the infants showed evidence of perceptual constancy for the pitch of harmonic complexes. Finally, infants heard tonal complexes that signaled the same pitch categories but for which the fundamental frequency was removed. Infants were still able to categorize the harmonic complexes according to their pitch categories. These results suggest that by 7 months of age infants show fairly sophisticated pitch perception abilities similar to those demonstrated by adults.
Rankings of Published Price-Earnings Ratios and Value Investor Attention

Price-earnings (P/E) ratios are the most popular proxy for fundamental value and are widely published using a common methodology. This paper explores whether stocks with high P/E rankings are especially salient to individual investors with attention constraints. Consistent with the role of attention, P/E rankings predict the returns of strategies based on size, liquidity, and short-term reversals as well as increases in trading volume and liquidity. Financial data providers publish P/E ratios for stocks with positive earnings, but do not publish P/E ratios for stocks with negative earnings. P/E rankings predict returns and changes in trading volumes for stocks with positive earnings, but not for stocks with negative earnings. In an event study of all stocks which cross the 0 P/E threshold, the value of a positive P/E ratio is around 2.25%. Stocks which cross into positive P/E territory trade more actively than stocks which cross into negative P/E territory. Overall, a value-weighted extreme decile P/E attention strategy earns average monthly returns of 119 basis points from 1973 to 2015 with an annual Sharpe ratio of 0.94. These strategy returns are robust to fundamental factors and momentum in prices and earnings individually.
Thermal Stress and Coral Cover as Drivers of Coral Disease Outbreaks

Very little is known about how environmental changes such as increasing temperature affect disease dynamics in the ocean, especially at large spatial scales. We asked whether the frequency of warm temperature anomalies is positively related to the frequency of coral disease across 1,500 km of Australia's Great Barrier Reef. We used a new high-resolution satellite dataset of ocean temperature and 6 y of coral disease and coral cover data from annual surveys of 48 reefs to answer this question. We found a highly significant relationship between the frequencies of warm temperature anomalies and of white syndrome, an emergent disease, or potentially, a group of diseases, of Pacific reef-building corals. The effect of temperature was highly dependent on coral cover because white syndrome outbreaks followed warm years, but only on high (>50%) cover reefs, suggesting an important role of host density as a threshold for outbreaks. Our results indicate that the frequency of temperature anomalies, which is predicted to increase in most tropical oceans, can increase the susceptibility of corals to disease, leading to outbreaks where corals are abundant.
Impact of Chronic Condition Status and Severity on Dental Utilization for Iowa Medicaid-Enrolled Children

Background:Although Medicaid-enrolled children with a chronic condition (CC) may be less likely to use dental care because of factors related to their CC, dental utilization for this population is poorly understood. Objective:To assess the relationship between CC status and CC severity, respectively, on dental utilization for Iowa Medicaid-enrolled children. Research Design:Retrospective cohort study of Iowa Medicaid data (January 1, 2003 to December 31, 2006). Subjects:Medicaid-enrolled children aged 3 to 14 (N = 71,115) years. Measures:The 3M Corporation Clinical Risk Grouping methods were used to assess CC status (no/yes) and CC severity (episodic/life-long/malignancy/complex). The outcome variable was any dental utilization in 2006. Secondary outcomes included use of diagnostic, preventive, routine restorative, or complex restorative dental care. Results:After adjusting for model covariates, Iowa Medicaid-enrolled children with a CC were significantly more likely to use each type of dental care except routine restorative care (P = 0.86) than those without a CC, although the differences in the odds were small (4%–6%). Compared with Medicaid-enrolled children with an episodic CC, children with a life-long CC were less likely to use routine restorative care (P < 0.0001), children with a malignancy were more likely to use complex restorative care (P < 0.03), and children with a complex CC were less likely to use each type of dental care except complex restorative care (P = 0.97). Conclusions:There were differences in dental utilization for Iowa Medicaid-enrolled children by CC status and CC severity. Children with complex CCs were the least likely to use dental care. Future research efforts should seek to understand why subgroups of Medicaid-enrolled children with a CC exhibit lower dental utilization.
Why Americans Hate the Media and How It Matters

List of Illustrations ix Acknowledgments xiii Chapter 1: Why Is Everyone Mad at the Mainstream Media? 1 Chapter 2: Political Conflict with the Press in the Pre-Polling Era 10 Chapter 3: The Emergence of the Institutional News Media in an Era of Decreasing Political Polarization 39 Chapter 4: The Institutional News Media in an Era of Political Polarization and Media Fragmentation 65 Chapter 5: Sources of Antipathy toward the News Media 108 Chapter 6: News Media Trust and Political Learning 138 Chapter 7: News Media Trust and Voting 176 Chapter 8: The News Media in a Democracy 194 References 221 Index 257
Social Capability and Economic Growth

The conventional wisdom is that postwar economic growth has been unpredictable. In the 1960s few observers accurately forecast which countries would grow quickly. In this paper we show that indexes of social development constructed in the early 1960s have considerable predictive power. These results indicate the importance of "social capability" for economic growth. We emphasize that social arrangements matter for reasons beyond those discussed in recent work on trust and social capital. However, we are also able to show that one of the indexes may be a useful proxy for social capital in developing countries.
Changes in myosin heavy chain and its localization in rat heart in association with hypobaric hypoxia‐induced pulmonary hypertension

Experimental pulmonary hypertension induced in a hypobaric hypoxic environment (HHE) is characterized by structural remodelling of the heart. In rat cardiac ventricles, pressure and volume overload are well known to be associated with changes in cardiac myosin heavy chain (MHC) isoforms. To study the effects of HHE on the MHC profile in the ventricles, 83 male Wistar rats were housed in a chamber at the equivalent of 5500 m altitude for 1–8 weeks. Pulmonary arterial pressure, right ventricular free wall (RVFW) weight, the ratio of RVFW weight over body weight (BW), the ratio of left ventricular free wall (LVFW) weight over BW, and myocyte diameter in both ventricles showed significant increases after 1 week, 2 weeks, 1 week, 6 weeks, and 4 weeks of HHE, respectively. Semi‐quantitative reverse transcriptase–polymerase chain reaction revealed that β‐MHC mRNA expression was increased significantly in both ventricles at 6 and 8 weeks of HHE, whereas α‐MHC mRNA expression was decreased significantly at 6 and 8 weeks of HHE in the right ventricle (RV) and at 6 weeks of HHE in the left ventricle (LV). The percentage of myosin containing the β‐MHC isoform was increased significantly at 4–8 weeks of HHE in RV and at 6 weeks of HHE in LV. In situ hybridization showed that the area of strong staining for β‐MHC mRNA was increased in both ventricles at 8 weeks of HHE, and showed a decrease from RVFW to cardiac septum, and from cardiac septum to LVFW. These results suggest that HHE has a significant effect on the expression of both MHC mRNA and protein in the heart, particularly in RV. These changes may reflect a role for cardiac MHC in the response to pulmonary hypertension in HHE. Copyright © 2002 John Wiley & Sons, Ltd.
Ticagrelor Versus Clopidogrel in Patients With ST-Elevation Acute Coronary Syndromes Intended for Reperfusion With Primary Percutaneous Coronary Intervention: A Platelet Inhibition and Patient Outcomes (PLATO) Trial Subgroup Analysis

Background— Aspirin and clopidogrel are recommended for patients with acute coronary syndromes (ACS) or undergoing coronary stenting. Ticagrelor, a reversible oral P2Y12-receptor antagonist, provides faster, greater, and more consistent platelet inhibition than clopidogrel and may be useful for patients with acute ST-segment elevation (STE) ACS and planned primary percutaneous coronary intervention. Methods and Result— Platelet Inhibition and Patient Outcomes (PLATO), a randomized, double-blind trial, compared ticagrelor with clopidogrel for the prevention of vascular events in 18 624 ACS patients. This report concerns the 7544 ACS patients with STE or left bundle-branch block allocated to either ticagrelor 180-mg loading dose followed by 90 mg twice daily or clopidogrel 300-mg loading dose (with provision for 300 mg clopidogrel at percutaneous coronary intervention) followed by 75 mg daily for 6 to 12 months. The reduction of the primary end point (myocardial infarction, stroke, or cardiovascular death) with ticagrelor versus clopidogrel (10.8% versus 9.4%; hazard ratio [HR], 0.87; 95% confidence interval, 0.75 to 1.01; P=0.07) was consistent with the overall PLATO results. There was no interaction between presentation with STE/left bundle-branch block and randomized treatment (interaction P=0.29). Ticagrelor reduced several secondary end points, including myocardial infarction alone (HR, 0.80; P=0.03), total mortality (HR, 0.82; P=0.05), and definite stent thrombosis (HR, 0.66; P=0.03). The risk of stroke, low in both groups, was higher with ticagrelor (1.7% versus 1.0%; HR,1.63; 95% confidence interval, 1.07 to 2.48; P=0.02). Ticagrelor did not affect major bleeding (HR, 0.98; P=0.76). Conclusion— In patients with STE-ACS and planned primary percutaneous coronary intervention, the effects of ticagrelor were consistent with those observed in the overall PLATO trial. Clinical Trial Registration— URL: http://www.ClinicalTrials. gov. Unique identifier: NCT00391872.
On the number of samples needed in light field rendering with constant-depth assumption

While several image-based rendering techniques have been proposed to successfully render scenes/objects from a large collection (e.g., thousands) of images without explicitly recovering 3D structures, the minimum number of images needed to achieve a satisfactory rendering result remains an open problem. This paper is the first attempt to investigate the lower bound for the number of samples needed in the Lumigraph/light field rendering. To simplify the analysis, we consider an ideal scene with only a point that is between a minimum and a maximum range. Furthermore, constant-depth assumption and bilinear interpolation are used for rendering. The constant-depth assumption serves to choose "nearby" rays for interpolation. Our criterion to determine the lower bound is to avoid horizontal and vertical double images, which are caused by interpolation using multiple nearby rays. This criterion is based on the causality requirement in scale-space theory, i.e., no "spurious details" should be generated while smoothing. Using this criterion, closed-form solutions of lower bounds are obtained for both 3D plenoptic function (Concentric Mosaics) and 4D plenoptic function (light field). The bounds are derived completely from the aspect of geometry and are closely related to the resolution of the camera and the depth range of the scene. These tower bounds are further verified by our experimental results.
Simultaneous ultrasound identification of acute appendicitis, septic thrombophlebitis of the portal vein and pyogenic liver abscess.

A 17-year-old youth from a rural background presented to a secondary hospital with a 3-week history of epigastric pain, constipation and weight loss. He had a temperature of 40°C, marked right upper quadrant tenderness and a white cell count of 21.1 × 10/l. The chest and abdominal radiographs were normal, but an abdominal ultrasound scan showed two small areas of low echogenicity in the left lobe of the liver consistent with abscesses (Fig. 1). The main portal vein was distended, measuring 16 mm in diameter, and contained echogenic material indicative of thrombus (Fig. 2). In the right iliac fossa there were features of an inflamed appendix, as demonstrated by an 8 mm diameter tubular, non-compressible, fluid-filled viscus, with a distal blind end and an echogenic focus filling the lumen proximally (Fig. 3). A diagnosis was made of acute appendicitis, complicated by septic thrombophlebitis of the portal vein (pylephlebitis) and pyogenic liver abscesses. Appendicectomy was performed later that day, revealing an inflamed appendix, confirmed histologically. The patient was treated with perioperative intravenous triple antibiotics and commenced on anticoagulants following surgery. Discharge was on the 10th postoperative day. Regular out-patient follow-up documented progressive decrease in the size of the portal vein thrombus and the liver abscesses. The abdominal ultrasound scan 4 months post surgery demonstrated a completely normal upper abdomen.
Inhibition of Cytokine-Induced Fractalkine Production by Bacterial Invasion of Human-Dermal Fibroblasts

Fractalkine (FKN/CX3CL1) is an atypical chemokine, for which a major biological function has not yet emerged. However, recent data suggest a role in immune responses in the skin. In this study, we analyzed fractalkine (FKN) secretion by human-dermal fibroblasts after exposure to pro-inflammatory cytokines or to invasive and noninvasive strains of Escherichia coli. Incubation of fibroblasts with TNF-α and IL-1β induced a delayed expression of soluble FKN, compared with the rapid secretion of other chemokines including IL-8 (CXCL8), monocyte chemotactic protein-1 (CCL2), and RANTES (regulated upon activation, normal T cell expressed and secreted; CCL5). TNF-α and IFN-γ gamma were more potent at inducing FKN secretion than was IL-1β. Very little FKN was detected on the cell surface. FKN was not detected after incubation with the bacteria, regardless of the strain used. In contrast, both invasive and noninvasive E. coli triggered the release of IL-8 and monocyte chemotactic protein-1 in a dose-response manner, whereas RANTES was produced only in response to the invasive strain. Finally, incubation of fibroblasts with the invasive strain of E. coli inhibited TNF-α– and IFN-γ–induced production of FKN. These results demonstrate for the first time that human-dermal fibroblasts express FKN, and that the characteristics of FKN secretion are distinct from those of other chemokines produced by these cells during immune responses in the dermis. In addition, our data indicate that bacterial invasion of dermal fibroblasts actively modulates FKN expression.
(N-sec-Butyl-N-n-propyldithiocarbamato-κ2 S,S′)triphenyltin(IV)

The Sn atom in the title compound, [Sn(C6H5)3(C8H16NS2)], is pentacoordinated by two S atoms, derived from an asymmetrically coordinating dithiocarbamate ligand, and three ipso-C atoms. The coordination geometry is intermediate between square-pyramidal and trigonal-bipyramidal, with a leaning towards the latter. The presence of close intramolecular C—H⋯S contacts preclude the S atoms from forming significant intermolecular interactions. Rather, molecules are consolidated in the crystal structure by C—H⋯π interactions.
Application of Ultrasound in a Closed System: Optimum Condition for Antioxidants Extraction of Blackberry (Rubus fructicosus) Residues

Blackberry processing generates up to 20% of residues composed mainly of peel, seeds and pulp that are abundant in flavonoids. The objective of this study was to optimize the ultrasound conditions, in a closed system, for antioxidants extraction, using the response surface methodology. Blackberry (Rubus fructicosus) residues were analyzed for total phenolics, total anthocyanins, and antioxidant activity by ABTS and DPPH. The selected independent variables were ultrasound amplitude (X1: 80%–90%) and extraction time (X2: 10–15 min), and results were compared with conventional extraction methods. The optimal conditions for antioxidants extraction were 91% amplitude for 15 min. The results for total phenolic content and anthocyanins and antioxidant activity by ABTS and DPPH were of 1201.23 mg gallic acid equivalent (GAE)/100 g dry weight basis (dw); 379.12 mg/100 g·dw; 6318.98 µmol Trolox equivalent (TE)/100 g·dw and 9617.22 µmol TE/100 g·dw, respectively. Compared to solvent extraction methods (water and ethanol), ultrasound achieved higher extraction of all compounds except for anthocyanins. The results obtained demonstrated that ultrasound is an alternative to improve extraction yield of antioxidants from fruit residues such as blackberry.
Monitoring Training in Elite Soccer Players: Systematic Bias between Running Speed and Metabolic Power Data

Abstract We compared measurements of high-intensity activity during field-based training sessions in elite soccer players of different playing positions. Agreement was appraised between measurements of running speed alone and predicted metabolic power derived from a combination of running speed and acceleration. Data was collected during a 10-week phase of the competitive season from 26 English Premier League outfield players using global positioning system technology. High-intensity activity was estimated using the total distance covered at speeds >14.4 km · h−1 (TS) and the equivalent metabolic power threshold of >20 W · kg−1 (TP), respectively. We selected 0.2 as the minimally important standardised difference between methods. Mean training session TS was 478±300 m vs. 727±338 m for TP (p<0.001). This difference was greater for central defenders (~ 85%) vs. wide defenders and attackers (~ 60%) (p<0.05). The difference between methods also decreased as the proportion of high-intensity distance within a training session increased (R2=0.43; p<0.001). We conclude that the high-intensity demands of soccer training are underestimated by traditional measurements of running speed alone, especially in training sessions or playing positions associated with less high-intensity activity. Estimations of metabolic power better inform the coach as to the true demands of a training session.
Upper Respiratory Tract Colonization by Gram-Negative Rods in Patients with Chronic Lymphocytic Leukemia: Analysis of Risk Factors

The aim of the study was to assess the frequency and predisposing factors of colonization of upper respiratory tract by Gram-negative rods (GNRs) in chronic lymphocytic leukemia (CLL) patients. Antimicrobial susceptibility of the isolated strains was determined. A significantly higher frequency of GNR colonization in CLL patients was observed (36.7%) in comparison to healthy volunteers (8.3%). GNR isolates mainly belonged to the Enterobacteriaceae family. Three isolates of GNR demonstrating presence of AmpC β-lactamases and one ESBL-producing strain were obtained from CLL patients. GNR colonization rate was higher among CLL patients with lower level of IgG in serum (P = 0.017), with higher number of neutrophils (P = 0.039) or higher number of lymphocytes in serum (P = 0.053). The longer the time elapsed since diagnosis, the higher the frequency of GNR colonization observed. Multivariate analysis showed importance of the Rai stage, number, and type of infections as independent predictors of GNR colonization in CLL patients.
Monte Carlo study elucidates the type 1/type 2 choice in apoptotic death signaling in normal and cancer cells

Apoptotic cell death is coordinated through two distinct (type 1 and type 2) intracellular signaling pathways. How the type 1/type 2 choice is made remains a fundamental problem in the biology of apoptosis and has implications for apoptosis related diseases and therapy. We study the problem of type 1/type 2 choice in silico utilizing a kinetic Monte Carlo model of cell death signaling. Our results show that the type 1/type 2 choice is linked to deterministic versus stochastic cell death activation, elucidating a unique regulatory control of the apoptotic pathways. Consistent with previous findings, our results indicate that caspase 8 activation level is a key regulator of the choice between deterministic type 1 and stochastic type 2 pathways, irrespective of cell types. Expression levels of signaling molecules downstream also regulate the type 1/type 2 choice. A simplified model of DISC clustering elucidates the mechanism of increased active caspase 8 generation, and type 1 activation, in cancer cells having increased sensitivity to death receptor activation. We demonstrate that rapid deterministic activation of the type 1 pathway can selectively target those cancer cells, especially if XIAP is also inhibited; while inherent cell-to-cell variability would allow normal cells stay protected.
Women's compliance with current folic acid recommendations and achievement of optimal vitamin status for preventing neural tube defects.

BACKGROUND The timing of folic acid supplement usage is critical to preventing pregnancies affected by neural tube defects (NTDs) because the neural tube closes by Day 28 post-conception. We investigated compliance of pregnant women with current folic acid recommendations (400 µg/day from preconception to 12 weeks) in relation to achieving a folate status associated with lowest risk of NTDs. METHODS From a sample of 296 women with singleton uncomplicated pregnancies attending an antenatal clinic in Northern Ireland, those who reported taking folic acid in the first trimester (n = 226) were investigated. Samples were taken at 14 weeks gestation to measure serum concentrations of folate and vitamin B12 (related to folate and an independent predictor of NTD), and dietary B-vitamin intake and folic acid usage were investigated. RESULTS Although the majority of the overall sample (84%) reported taking folic acid supplements in the first trimester, only 19% had started before conception, as recommended. Multigravidae compared with primigravidae women were less likely to have followed the recommendations correctly (P= 0.001). At 14 weeks, red cell folate (considered a reliable biomarker of previous 3 months, covering time of neural tube closure) was correlated (r = 0.320, P < 0.001) with the reported duration of folic acid usage, and was lower (P< 0.0001) in women who started folic acid after conception. CONCLUSIONS Red cell folate concentrations in women not complying with recommendations were suboptimal in relation to NTD risk. The findings generally support the recent official recommendation to the Chief Medical Officer for mandatory fortification of food with folic acid in the UK.