Miracle-dz/UniFAR-FTUs huggingface dataset:
Intent models for contextualising and diversifying query suggestions

The query suggestion or auto-completion mechanisms help users to type less while interacting with a search engine. A basic approach that ranks suggestions according to their frequency in query logs is suboptimal. Firstly, many candidate queries with the same prefix can be removed as redundant. Secondly, the suggestions can also be personalised based on the user's context. These two directions to improve the mechanisms' quality can be in opposition: while the latter aims to promote suggestions that address search intents that a user is likely to have, the former aims to diversify the suggestions to cover as many intents as possible. We introduce a contextualisation framework that utilises a short-term context using the user's behaviour within the current search session, such as the previous query, the documents examined, and the candidate query suggestions that the user has discarded. This short-term context is used to contextualise and diversify the ranking of query suggestions, by modelling the user's information need as a mixture of intent-specific user models. The evaluation is performed offline on a set of approximately 1.0M test user sessions. Our results suggest that the proposed approach significantly improves query suggestions compared to the baseline approach.
Porcine Dendritic Cells as an In Vitro Model to Assess the Immunological Behaviour of Streptococcus suis Subunit Vaccine Formulations and the Polarizing Effect of Adjuvants

An in vitro porcine bone marrow-derived dendritic cell (DC) culture was developed as a model for evaluating immune polarization induced by adjuvants when administered with immunogens that may become vaccine candidates if appropriately formulated. The swine pathogen Streptococcus suis was chosen as a prototype to evaluate proposed S. suis vaccine candidates in combination with the adjuvants Poly I:C, Quil A ®, Alhydrogel ®, TiterMax Gold ® and Stimune ®. The toll-like receptor ligand Poly I:C and the saponin Quil A ® polarized swine DC cytokines towards a type 1 phenotype, with preferential production of IL-12 and TNF-α. The water-in-oil adjuvants TiterMax Gold ® and Stimune ® favoured a type 2 profile as suggested by a marked IL-6 release. In contrast, Alhydrogel ® induced a type 1/type 2 mixed cytokine profile. The antigen type differently modified the magnitude of the adjuvant effect, but overall polarization was preserved. This is the first comparative report on swine DC immune activation by different adjuvants. Although further swine immunization studies would be required to better characterize the induced responses, the herein proposed in vitro model is a promising approach that helps assessing behaviour of the vaccine formulation rapidly at the pre-screening stage and will certainly reduce numbers of animals used while advancing vaccinology science.
3D calculation and modeling of eddy current losses in a large power transformer

Elimination of hot spots and reduction of eddy current losses in structural parts is one of the important constituents of transformer design. In this work, the eddy current losses in the clamping frame, transformer tank and electromagnetic shielding are calculated using a 3D finite element method. The clamping frame, transformer tank and electromagnetic shielding are modeled by surface impedance method. The paper analyses the effects of electromagnetic shielding and magnetic shunts on the eddy current loss reduction in the transformer tank.
Arginine enhancement of cell dissociation in suspension-cultured of aromatic rice cells (Oryza sativa L. var Khao Dawk Mali 105)

Suspension culture of Oryza sativa L. var. Khao Dawk Mali 105 was initiated from embryogenic region of callus derived from mature seeds cultured in the modified N6 medium supplemented with 1 mg/l 2,4-dichlorophenoxyacetic acid (2,4-D), 0.25 mg/l kinetin, 2 % sucrose, 5 mM proline and various nitrogen sources. Three types of suspension-cultured medium (SM) with the supplementation of inorganic nitrogen (SM1), or organic nitrogen plus arginine (SM2), or inorganic nitrogen plus arginine (SM3) were used.The suspension-cultured of rice callus in the SM gave cytoplasmically dense cell and homogeneous aggregation cell size larger than 1 mm, while those in the SM2 produced cytoplasmically clear cell and aggregated cell size smaller than 1 mm. The addition of arginine to SM with inorganic nitrogen (SM3) seemed to combine the desirable characters of finely dispersed cell aggregate and cytoplasmically dense cell. It was revealed by scanning electron micrographs indicating a difference in intercellular layer while cultured in 1 mM arginine containing SM medium was less deeply embedded in intercellular layer than in arginine-free medium. A finely dispersed cell suspension was obtained from rice callus tissue in SM supplemented with 1mM arginine. These results suggested that the suspension-cultured medium with inorganic nitrogen plus arginine should be suitable for generating an established suspension cell line for selection experiment as well as protoplast isolation.
Ieee Transactions on Pattern Analysis and Machine Intelligence 1 Mutual Information for Lucas-kanade Tracking (milk): an Inverse Compositional Formulation

Mutual Information (MI) is popular for registration via function optimisation. This work proposes an inverse compositional formulation of MI for Levenberg-Marquardt optimisation. This yields a constant Hessian, which may be precomputed. Speed improvements of 15% were obtained, with convergence accuracies similar those of the standard formulation.
Bayesian sensor fusion with fast and low power stochastic circuits

As the physical limits of Moore's law are being reached, a research effort is launched to achieve further performance improvements by exploring computation paradigms departing from standard approaches. The BAMBI project (Bottom-up Approaches to Machines dedicated to Bayesian Inference) aims at developing hardware dedicated to probabilistic computation, which extends logic computation realised by boolean gates in current computer chips. Such probabilistic computing devices would allow to solve faster and at a lower energy cost a wide range of Artificial Intelligence applications, especially when decisions need to be taken from incomplete data in an uncertain environment. This paper describes an architecture where very simple operators compute on a time coding of probability values as stochastic signals. Simulation tests and a reconfigurable logic hardware implementation demonstrated the feasibility and performances of the proposed inference machine. Hardware results show this architecture can quickly solve Bayesian sensor fusion problems and is very efficient in terms of energy consumption.
The Impact of Consumer Credit Access on Unemployment

Unemployed households’ access to unsecured revolving credit more than tripled over the last three decades. This article analyses how both cyclical fluctuations and trend increases in credit access impact the business cycle. The main quantitative result is that credit expansions and contractions have contributed to moderately deeper and more protracted recessions over the last 40 years. As more individuals obtained credit from 1977 to 2010, cyclical credit fluctuations affected a larger share of the population and became more important determinants of employment dynamics. Even though business cycles are more volatile, newborns strictly prefer to live in the economy with growing, but fluctuating, access to credit markets.
Anti-oxidative effects of rooibos tea extract on autoxidation and thermal oxidation of lipids.

Powdered rooibos tea extract (RTE), which is rich in polyphenols, is made from rooibos tea by freeze-drying. "Rooibos" is Afrikaans for "red bush," and the scientific name is "Aspalathus linearis. " It is a broom-like member of the legume family of plants and is used to make an herbal tea which has been popular in South Africa for generations and is now consumed in many countries. In the present work, the anti-oxidative effect of RTE on oils and fats in autoxidation or thermal oxidation was studied, and it was confirmed that RTE has a very strong anti-oxidative effect on emulsifying oils owing to the water-soluble polyphenols such as rutin and quercetin contained in RTE. RTE was found to have a strong ability to quench radicals generated in the water phase, and to confer higher thermal stability against deep fat frying than tocopherol. But RTE showed little anti-oxidative effect on frying oil because of its lower oil-solubility.
The Kinematics and Physical Conditions of the Ionized Gas in Markarian 509. I. Chandra High Energy Grating Spectroscopy

We observed the Seyfert 1 galaxy Mrk 509 for ~59 ks with the Chandra high-energy transmission gratings, simultaneously with HST/STIS and RXTE. Here we present a detailed analysis of the soft X-ray spectrum observed with Chandra. We measure strong absorption lines from He-like Ne and Mg and from H-like N, O, and Ne. Weaker absorption lines may also be present. The lines are unresolved except for Ne X Lyα (λ12.134) and Ne IX 1s2-1s2p (λ13.447), which appear to be marginally resolved. The profiles are blueshifted with respect to the systemic velocity of Mrk 509, indicating an outflow of ~-200 km s-1. There is also a hint that the profiles may have a velocity component near systemic. The soft X-ray spectrum can be described in remarkable detail with a simple, single-zone photoionized absorber having an equivalent neutral hydrogen column density of 2.06 × 1021cm-2 and an ionization parameter of log ξ = 1.76 (or log U = 0.27). Although the photoionized gas almost certainly is comprised of matter in more than one ionization state and may consist of several kinematic components, data with better spectral resolution and signal-to-noise ratio would be required to justify a more complex model. The UV data, on the other hand, have a velocity resolution of ~10 km s-1 and can easily detect eight kinematic components, covering roughly the same velocities as the X-ray absorption profiles. Even though the X-ray and UV absorbers share the same velocity space, the UV absorbers have a much smaller column density and ionization state. We show that models of the X-ray data do not predict significant UV absorption and are therefore consistent with the UV data. Finally, we do not detect any soft X-ray emission lines.
Chronic Hepatitis B and Liver Cancer Risks among Asian Immigrants in New York City: Results from a Large, Community-Based Screening, Evaluation, and Treatment Program

Background: Hepatitis B virus (HBV) infection, the predominant cause of hepatocellular carcinoma (HCC) worldwide, disproportionately affects Asian Americans. Limited data exist on the variability and characteristics of infection that determine disease progression risk within U.S. Asian ethnic subgroups. Methods: Retrospective analyses were conducted on a large, community-based HBV screening and treatment program in New York City (NYC). From 2004 to 2008, the program enrolled 7,272 Asian-born individuals. Determinants of HBV seroprevalence were calculated and risk factors for HCC progression were compared across Asian subgroups. Results: Among newly tested individuals, 13% were HBV positive. Seroprevalence varied significantly with age, gender, education, birthplace, and family history of infection. Chinese-born individuals, particularly from the Fujian province, had the highest seroprevalence (23.2% and 33.1%, respectively). Clinical and virologic characteristics placed HBV-infected individuals at significant risk for HCC. Significant differences in HCC risk existed among Asian subgroups in bivariate analysis, including age, gender, HBV viral load, and HBeAg status. Differences in HBV genotype and family history of HCC may further HCC risk among subgroups. Conclusions: Asian immigrants in NYC have a high prevalence of HBV infection and are at significant risk of disease progression and HCC. Although heterogeneity in HBV seroprevalence was found by Asian subgroups, HCC risk among infected individuals was primarily explained by age and gender differences. Country and province of birth, age, and gender may further explain seroprevalence differences. Impact: Findings provide estimates of HBV burden in Asian ethnic subgroups and identify high-risk groups to target for screening and treatment that can prevent HCC. See all the articles in this CEBP Focus section, “Cancer in Asian and Pacific Islander Populations. ” Cancer Epidemiol Biomarkers Prev; 23(11); 2229–39. ©2014 AACR.
Ontogeny of the F8Famide‐like (morphine‐modulating) peptides in the central nervous system of rats

FLFQPQRF‐NH2 (F8Famide; FMRFamide‐like peptide; morphine‐modulating peptide) is a peptide isolated from bovine brain. It has some opiate analgesia modulating effects. In an adult rat central nervous system, F8Famide‐like immunoreactivity is found in high concentrations in the posterior pituitary, hypothalamus, pons, medulla, and dorsal spinal cord.
Maturation of selected human mitochondrial tRNAs requires deadenylation

Human mitochondria contain a genome (mtDNA) that encodes essential subunits of the oxidative phosphorylation system. Expression of mtDNA entails multi-step maturation of precursor RNA. In other systems, the RNA life cycle involves surveillance mechanisms, however, the details of RNA quality control have not been extensively characterised in human mitochondria. Using a mitochondrial ribosome profiling and mitochondrial poly(A)-tail RNA sequencing (MPAT-Seq) assay, we identify the poly(A)-specific exoribonuclease PDE12 as a major factor for the quality control of mitochondrial non-coding RNAs. The lack of PDE12 results in a spurious polyadenylation of the 3’ ends of the mitochondrial (mt-) rRNA and mt-tRNA. While the aberrant adenylation of 16S mt-rRNA did not affect the integrity of the mitoribosome, spurious poly(A) additions to mt-tRNA led to reduced levels of aminoacylated pool of certain mt-tRNAs and mitoribosome stalling at the corresponding codons. Therefore, our data uncover a new, deadenylation-dependent mtRNA maturation pathway in human mitochondria. DOI: http://dx.doi. org/10.7554/eLife.27596. 001
Usefulness of Gd‐EOB‐DTPA‐enhanced MR imaging in the evaluation of simple steatosis and nonalcoholic steatohepatitis

To evaluate the usefulness of gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid (Gd‐EOB‐DTPA)‐enhanced MR imaging (EOB‐MRI) in differentiating between simple steatosis and nonalcoholic steatohepatitis (NASH), as compared with MR in‐phase/out‐of‐phase imaging. The correlations between the MR features and histological characteristics were preliminarily investigated.
Active Complementary Control for Affine Nonlinear Control Systems With Actuator Faults

This paper is concerned with the problem of active complementary control design for affine nonlinear control systems with actuator faults. The outage and loss of effectiveness fault cases are considered. In order to achieve the performance enhancement of the faulty control system, the complementary control scheme is designed in two steps. Firstly, a novel fault estimation scheme is developed. Then, by using the fault estimations to reconstruct the faulty system dynamics and introducing a cost function as the optimization objective, a nearly optimal complementary control is obtained online based on the adaptive dynamic programming (ADP) method. Unlike most of the previous ADP methods with the addition of a probing signal, new adaptive weight update laws are derived to guarantee the convergence of neural network weights and the stability of the closed-loop system, which strongly supports the online implementation of the ADP method. Finally, two simulation examples are given to illustrate the performance and effectiveness of the proposed method.
FGF-1/-3/FGFR4 signaling in cancer-associated fibroblasts promotes tumor progression in colon cancer through Erk and MMP-7

Cancer‐associated fibroblasts (CAFs), as the activated fibroblasts in the tumor stroma, are important modifiers of tumour progression. In the present study, we observed that azoxymethane and dextran sodium sulfate treatments induced increasingly severe colorectal mucosal inflammation and the intratumoural accumulation of CAFs. Fibroblast growth factor (FGF)‐1 and FGF‐3 were detected in infiltrating cells, and FGFR4, the specific receptor for FGF‐1 and FGF‐3, was detected in colon cancer tissues. The phosphorylation of FGFR4 enhanced the production of metalloproteinase (MMP)‐7 and mitogen‐activated protein kinase kinase (Mek)/extracellular signal‐regulated kinase (Erk), which was accompanied by excessive vessel generation and cell proliferation. Moreover, we separated CAFs, pericarcinoma fibroblasts (PFs), and normal fibroblasts (NFs) from human colon tissue specimens to characterize the function of CAFs. We observed that CAFs secrete more FGF‐1/‐3 than NFs and PFs and promote cancer cell growth and angiogenesis through the activation of FGFR4, which is followed by the activation of Mek/Erk and the modulation of MMP‐7 expression. The administration of FGF‐1/‐3‐neutralizing antibodies or the treatment of cells with FGFR4 siRNA or the FGFR4 inhibitor PD173074 markedly suppressed colon cancer cell proliferation and neovascularization. These observations suggest a crucial role for CAFs and FGF signaling in the initiation and progression of colorectal cancer. The inhibition of the FGF signaling pathway may be a useful strategy for the treatment of colon cancer.
Parametric Analysis of Vehicle Design Influence on the Four Phases of Whiplash Motion

Objective. The objective is to establish a basis for motor vehicle test requirements that measure component contributions to Whiplash Associated Disorders (WAD). Methods. Selected vehicle design features are evaluated with regard to their relative contributions to WAD measures. The motion of the occupant cervical spine associated with WAD is divided into four phases: retraction, extension, rebound, and protraction. Injury measures from the literature (NIC, extension moment, N km , and flexion moment) represent the injury potential during each of these phases. Four vehicle design factors that affect WAD motion (vehicle stiffness, seat stiffness, head restraint height and head restraint backset) were evaluated for their contributions to the injury measures. A detailed 50th percentile male model with a biofidelic neck was used in a 100-run Monte Carlo analysis of a rear impact, varying the design factors across the values documented in the literature. Total energy was held constant and Delta V was 10 kph. Results. Vehicle stiffness has a strong influence on the retraction (70%), rebound (43%), and protraction (47%) phases. Headrest backset demonstrates a strong influence on the extension (49%) and rebound (39%) phases. Conclusions. For WAD protection rating, the vehicle should be viewed as a system whereby the complex interactions among the vehicle, seat, and occupant characteristics all contribute to the WAD potential.
Genetics of dyslexia: the evolving landscape

Dyslexia is among the most common neurodevelopmental disorders, with a prevalence of 5–12%. At the phenotypic level, various cognitive components that enable reading and spelling and that are disturbed in affected individuals can be distinguished. Depending on the phenotype dimension investigated, inherited factors are estimated to account for up to 80%. Linkage findings in dyslexia are relatively consistent across studies in comparison to findings for other neuropsychiatric disorders. This is particularly true for chromosome regions 1p34–p36, 6p21–p22, 15q21 and 18q11. Four candidate genes have recently been identified through systematic linkage disequilibrium studies in linkage region 6p21–p22, and through cloning approaches at chromosomal breakpoints. Results indicate that a disturbance in neuronal migration is a pathological correlate of dyslexia at the functional level. This review presents a summary of the latest insights into the genetics of dyslexia and an overview of anticipated future developments.
A Chinese Herbal Formula, Gengnianchun, Ameliorates β-Amyloid Peptide Toxicity in a Caenorhabditis elegans Model of Alzheimer's Disease

Alzheimer's disease (AD) is an age-related neurodegenerative disorder, and the few drugs that are currently available only treat the symptoms. Traditional medicine or phytotherapy has been shown to protect against AD. In our previous studies, Gengnianchun (GNC), a traditional Chinese medicine formula with a prolongevity effect, protected against Aβ-induced cytotoxicity in pheochromocytoma cells (PC-12 cells) and hippocampal cells. Here, we investigated the effects and possible mechanisms by which GNC protected against Aβ toxicity using transgenic Caenorhabditis elegans CL4176. Our results showed that GNC effectively delayed the Aβ toxicity-triggered body paralysis of CL4176 worms. GNC decreased Aβ by reducing Aβ mRNA levels. Moreover, GNC significantly reduced reactive oxygen species in the AD model worms compared with the controls. In addition, GNC upregulated the daf-16, sod-3, hsp-16.2 genes, and enhanced DAF-16 translocation from the cytoplasm to the nuclei under oxidative stress conditions. GNC treatment of C. elegans strains lacking DAF-16 did not affect the paralysis phenotype. Taken together, these findings suggest that GNC could protect against Aβ-induced toxicity via the DAF-16 pathway in C. elegans. Further studies are required to analyze its effectiveness in more complex animals.
Gabapentin attenuates late but not acute pain after abdominal hysterectomy

Background and objective: Gabapentin has been suggested to decrease acute postoperative pain. We evaluated the effect of gabapentin on pain after abdominal hysterectomy. Methods: Sixty patients scheduled for abdominal hysterectomy were randomized to receive orally gabapentin 400 mg 6 hourly or placebo. Treatment started 18 h preoperatively and continued for 5 postoperative days. Pain (visual analogue score) and consumption of morphine for 48 h and of oral paracetamol/codeine were recorded after 2, 4, 8, 24 and 48 h and on days 3‐5 postoperatively. After 1 month, patients were interviewed by phone for pain, and analgesic intake after hospital discharge. Results: Morphine consumption (mean ± SD) was 35 ± 15.7 mg in the control and 28 ± 12.1 mg in the gabapentin group (P = 0.21). Median number (range) of paracetamol 500 mg/codeine 30 mg tablets taken during days 3‐5 was 1.0 (0‐6) in the control and 2.0 (0‐9) in the gabapentin group (P = 0.35). The visual analogue scores at rest and after cough did not differ between the two groups (F = 0.92, df = 1, P = 0.34 and F = 0.56, df = 1, P = 0.46, respectively). One month after surgery, 22/27 (81%) of the control group and 9/25 (36%) of the gabapentin group reported pain in the surgical area (χ2 = 11.15, P = 0.002), while 11/27 (41%) of controls and 7/25 (28%) of gabapentin patients consumed analgesics for pain (χ2 = 0.93, P = 0.39). The intensity of pain was decreased in the gabapentin group (χ2 = 12.6, P = 0.003). Conclusions: Gabapentin has no effect on immediate pain after abdominal hysterectomy but decreases pain 1 month postoperatively.