Miracle-dz/UniFAR-FTUs huggingface dataset:
Medication use and risk of ovarian carcinoma: A prospective study

Inflammation and gonadotropins are hypothesized to influence ovarian carcinogenesis. In a prospective study, we evaluated ovarian cancer risk associated with self‐reported use of medications that influence inflammation or gonadotropin levels. The Breast Cancer Detection Demonstration Project Follow‐Up Study enrolled 61,431 women in 1979 and used telephone interviews and 3 mailed questionnaires through 1998 to update risk factor information and identify incident ovarian cancers. The 1992–95 questionnaire ascertained medication use, including duration and frequency of use for aspirin, acetaminophen, other nonsteroidal anti‐inflammatory drugs (NSAIDs), tranquilizers and histamine‐receptor antagonists. A Poisson regression analysis generated rate ratios (RRs) and 95% confidence intervals (CIs) for the 31,364 women who were at risk of ovarian cancer and responded to the questionnaire that queried regular medication use. One hundred sixteen women developed ovarian cancer during follow‐up. None of the anti‐inflammatory medications was associated with ovarian cancer, but the RR for more than 1 aspirin per day for 1 year or longer was 0.56 (95% CI 0.20–1.5) and the RR for more than 5 years of regular “other NSAID” use was 2.0 (95% CI 0.95–4.2). Regular tranquilizer use was not associated with ovarian cancer, but histamine‐receptor antagonists used regularly for more than 5 years (RR = 3.6, 95% CI 1.4–9.1) or more than once daily (RR = 3.1, 95% CI 1.5–6.5) appeared to increase risk. In our study, neither anti‐inflammatory medications nor anti‐psychotic medications were associated with ovarian cancer. Potential associations with histamine‐receptor antagonists may warrant further study. © 2003 Wiley‐Liss, Inc.
CT contrast predicts pancreatic cancer treatment response to verteporfin-based photodynamic therapy

The goal of this study was to determine dominant factors affecting treatment response in pancreatic cancer photodynamic therapy (PDT), based on clinically available information in the VERTPAC-01 trial. This trial investigated the safety and efficacy of verteporfin PDT in 15 patients with locally advanced pancreatic adenocarcinoma. CT scans before and after contrast enhancement from the 15 patients in the VERTPAC-01 trial were used to determine venous-phase blood contrast enhancement and this was correlated with necrotic volume determined from post-treatment CT scans, along with estimation of optical absorption in the pancreas for use in light modeling of the PDT treatment. Energy threshold contours yielded estimates for necrotic volume based on this light modeling. Both contrast-derived venous blood content and necrotic volume from light modeling yielded strong correlations with observed necrotic volume (R2 = 0.85 and 0.91, respectively). These correlations were much stronger than those obtained by correlating energy delivered versus necrotic volume in the VERTPAC-01 study and in retrospective analysis from a prior clinical study. This demonstrates that contrast CT can provide key surrogate dosimetry information to assess treatment response. It also implies that light attenuation is likely the dominant factor in the VERTPAC treatment response, as opposed to other factors such as drug distribution. This study is the first to show that contrast CT provides needed surrogate dosimetry information to predict treatment response in a manner which uses standard-of-care clinical images, rather than invasive dosimetry methods.
Awareness and knowledge of pediatric cardio- pulmonary resuscitation in the community of Al-Khobar city

Background: The history of resuscitation going back thousands of years has been reported in literature throughout history. This concept has undergone several decisive revolutionary changes particularly in pediatrics. Although the cardio-pulmonary resuscitation (CPR) is relatively new in pediatrics, progress has been remarkable in the last a few decades. As it becomes more popular, especially under the influence of globalizing media, CPR also becomes a life requirement that is not restricted to health professionals. Materials and Methods: This was a cross-sectional community-based survey of 753 individuals of both sexes, visiting the first Pediatric Health Awareness Week held at Dammam University Hospital in April 2013. Data were collected by a personal face-to-face interview during which a short history was taken and a check list of sociodemographic data and questions related to infants' CPR was completed. Statistical analysis was performed by using SPSS. Results: The study was carried out on 753 subjects (602 Saudis, 151 non-Saudis, 483 females, and 270 males). The mean age of participants was 33.3 ± 10.9 years. The postsecondary school level of education was 37.5% among females versus 21.9% among males. Of the participants, 80.8% of the females and 86.5% of males were totally unaware of CPR. The mean number of children among participants was 3.5 ± 2.5 children. There were 150 participants (19.9%) with disabled children; 32% of them (6.4% of all participants) were completely unaware of CPR despite having disabled children. Overall, 15.5% of all female participants had attended some CPR course (s) compared with 6.1% of the males; 18.7% of the females had watched CPR program (s)/video (s) on TV or online compared to 11.1% of the males, and 59.4% of the females were willing and eager to participate in any CPR course compared with 29.3% of the males. The reasons for not wanting to attend CPR courses were as follows: 48.6% indicated that it was because of the unavailability of such courses, 41.4% said because of time constraints, and 10% gave financial reasons. Finally, the study showed that 365 females (84.3%) and 247 males (91.2%) did not know when to perform mouth-to-mouth resuscitation and/or chest compression, and would do it for the wrong reasons. Conclusion: Public awareness and knowledge on CPR was inadequate even among the younger population, and among parents with disabled children. The general public were willing to improve their knowledge and skills of CPR. We recommend that CPR courses/campaigns should be provided to the public and be included in high school curricula.
Open Access to Innovative Drugs: Treatment Substitutions or Treatment Expansion?

Granting open access to new antipsychotic medications by the California Medicaid Program fostered the desired substitution of second-generation medications for conventional antipsychotics. However, open access also generated an immediate but temporary influx of previously treated patients, many with a recent institutionalization, who restarted drug therapy using the new antipsychotics. Persistence with initial therapy declined, but cost outcomes improved due primarily to reduced nursing home use. Racial disparities were also reversed. Program administrators must use caution when evaluating the impact of unrestricted access on drug therapy outcomes and treatment costs given the changes in the characteristics of patients seeking treatment.
Trickle-down processes and their boundaries

It is possible to represent each of a number of Markov chains as an evolving sequence of connected subsets of a directed acyclic graph that grow in the following way: initially, all vertices of the graph are unoccupied, particles are fed in one-by-one at a distinguished source vertex, successive particles proceed along directed edges according to an appropriate stochastic mechanism, and each particle comes to rest once it encounters an unoccupied vertex. Examples include the binary and digital search tree processes, the random recursive tree process and generalizations of it arising from nested instances of Pitman's two-parameter Chinese restaurant process, tree-growth models associated with Mallows' $\phi$ model of random permutations and with Schutzenberger's non-commutative $q$-binomial theorem, and a construction due to Luczak and Winkler that grows uniform random binary trees in a Markovian manner. We introduce a framework that encompasses such Markov chains, and we characterize their asymptotic behavior by analyzing in detail their Doob-Martin compactifications, Poisson boundaries and tail $\sigma$-fields.
Random Projections for Classification: A Recovery Approach

Random projection has been widely used in data classification. It maps high-dimensional data into a low-dimensional subspace in order to reduce the computational cost in solving the related optimization problem. While previous studies are focused on analyzing the classification performance in the low-dimensional space, in this paper, we consider the recovery problem, i.e., how to accurately recover the optimal solution to the original high-dimensional optimization problem based on the solution learned after random projection. We present a simple algorithm, termed dual random projection, which uses the dual solution of the low-dimensional optimization problem to recover the optimal solution to the original problem. Our theoretical analysis shows that with a high probability, the proposed algorithm is able to accurately recover the optimal solution to the original problem, provided that the data matrix is (approximately) low-rank and/or optimal solution is (approximately) sparse. We further show that the proposed algorithm can be applied iteratively to reducing the recovery error exponentially.
Improved Annealing-Genetic Algorithm for Test Case Prioritization

Regression testing, which can improve the quality of software systems, is a useful but time consuming method. Many techniques have been introduced to reduce the time cost of regression testing. Among these techniques, test case prioritization is an effective technique which can reduce the time cost by processing relatively more important test cases at an earlier stage. Previous works have demonstrated that some greedy algorithms are effective for regression test case prioritization. Those algorithms, however, have lower stability and scalability. For this reason, this paper proposes a new regression test case prioritization approach based on the improved Annealing-Genetic algorithm which incorporates Simulated Annealing algorithm and Genetic algorithm to explore a bigger potential solution space for the global optimum. Three Java programs and five C programs were employed to evaluate the performance of the new approach with five former approaches such as Greedy, Additional Greedy, GA, etc. The experimental results showed that the proposed approach has relatively better performance as well as higher stability and scalability than those former approaches.
Understanding human resource management in the context of organizations and their environments.

INTRODUCTION . 238 The Need jor Understanding Hwnan Resource Management (HRM) in Context . 238 Theoretical Perspectives Relevant to Understanding HRM in Context 238 REVIEW OF EMPIRICAL RESEARCH 244 HRM and the Internal Contexts of Organizations . 244 HRM and the External Contexts oj Organizations 248 AN INTEGRATIVE PERSPECTIVE FOR RESEARCH ON HRM IN CONTEXT . 253 Theory-Driven Research 255 Methodological Issues 256
Development and Characterization of an Effective Food Allergy Model in Brown Norway Rats

Background Food allergy (FA) is an adverse health effect produced by the exposure to a given food. Currently, there is no optimal animal model of FA for the screening of immunotherapies or for testing the allergenicity of new foods. Objective The aim of the present study was to develop an effective and rapid model of FA in Brown Norway rats. In order to establish biomarkers of FA in rat, we compared the immune response and the anaphylactic shock obtained in this model with those achieved with only intraperitoneal immunization. Methods Rats received an intraperitoneal injection of ovalbumin (OVA) with alum and toxin from Bordetella pertussis, and 14 days later, OVA by oral route daily for three weeks (FA group). A group of rats receiving only the i.p. injection (IP group) were also tested. Serum anti-OVA IgE, IgG1, IgG2a, IgG2b and IgA antibodies were quantified throughout the study. After an oral challenge, body temperature, intestinal permeability, motor activity, and mast cell protease II (RMCP-II) levels were determined. At the end of the study, anti-OVA intestinal IgA, spleen cytokine production, lymphocyte composition of Peyer’s patches and mesenteric lymph nodes, and gene expression in the small intestine were quantified. Results Serum OVA-specific IgG1, IgG2a and IgG2b concentrations rose with the i.p. immunization but were highly augmented after the oral OVA administration. Anti-OVA IgE increased twofold during the first week of oral OVA gavage. The anaphylaxis in both IP and FA groups decreased body temperature and motor activity, whereas intestinal permeability increased. Interestingly, the FA group showed a much higher RMCP II serum protein and intestinal mRNA expression. Conclusions These results show both an effective and relatively rapid model of FA assessed by means of specific antibody titres and the high production of RMCP-II and its intestinal gene expression.
Aggressive Early Debridement in Treatment of Acute Periprosthetic Joint Infections After Hip and Knee Replacements

Background: Periprosthetic Joint Infection Remains a Dreaded Complication After Hip and Knee Replacement Surgery. Treatment Options for Acute Postoperative and Acute Hematogenous Infections Include Arthroscopic or Open Debridement With Retention or Exchange of the Prostheses. This Review Article Aims to Summarize the Evidence for Management of Acute Postoperative And Acute Hematogenous Infections. Methods: A Systematic Literature Search Was Performed Using a Computer-based Search Engine Covering Medline (OvidSP), PubMed Database (U.S. National Library of Medicine, National Institutes of Health), Embase, Web of Science, Cochrane and Google Scholar for Relevant Articles. Results: Common Themes Around Treatment of Acute Postoperative and Acute Hematogenous Infections Discussed in this Review Include the Timing of Intervention, Description of the Optimal Procedure and How we Perform it at our Institution, the Role of Arthroscopic Debridement, Most Commonly Isolated Micro-organisms and Prognostic Factors for Infection Control. Conclusion: Success in Treating Acute Postoperative and Acute Hematogenous Infections Depends on Early Diagnosis and Aggressive Surgical Debridement Combined With Effective Antibiotic Therapy.
Training Deterministic Parsers with Non-Deterministic Oracles

Greedy transition-based parsers are very fast but tend to suffer from error propagation. This problem is aggravated by the fact that they are normally trained using oracles that are deterministic and incomplete in the sense that they assume a unique canonical path through the transition system and are only valid as long as the parser does not stray from this path. In this paper, we give a general characterization of oracles that are nondeterministic and complete, present a method for deriving such oracles for transition systems that satisfy a property we call arc decomposition, and instantiate this method for three well-known transition systems from the literature. We say that these oracles are dynamic, because they allow us to dynamically explore alternative and nonoptimal paths during training — in contrast to oracles that statically assume a unique optimal path. Experimental evaluation on a wide range of data sets clearly shows that using dynamic oracles to train greedy parsers gives substantial improvements in accuracy. Moreover, this improvement comes at no cost in terms of efficiency, unlike other techniques like beam search.
Truth Serums for Massively Crowdsourced Evaluation Tasks

Incentivizing effort and eliciting truthful responses from agents in the absence of verifiability is a major challenge faced while crowdsourcing many types of evaluation tasks like labeling images, grading assignments in online courses, etc. In this paper, we propose new reward mechanisms for such settings that, unlike most previously studied mechanisms, impose minimal assumptions on the structure and knowledge of the underlying generating model, can account for heterogeneity in the agents' abilities, require no extraneous elicitation from them, and furthermore allow their beliefs to be (almost) arbitrary. Moreover, these mechanisms have the simple and intuitive structure of output agreement mechanisms, which, despite not incentivizing truthful behavior, have nevertheless been quite popular in practice. We achieve this by leveraging a typical characteristic of many of these settings, which is the existence of a large number of similar tasks.
Topology of the microsomal glycerol‐3‐phosphate acyltransferase Gpt2p/Gat1p of Saccharomyces cerevisiae

All glycerophospholipids are made from phosphatidic acid, which, according to the traditional view, is generated at the cytosolic surface of the ER. In yeast, phosphatidic acid is synthesized de novo by two acyl‐CoA‐dependent acylation reactions. The first is catalysed by one of the two homologous glycerol‐3‐phosphate acyltransferases Gpt2p/Gat1p and Sct1p/Gat2p, the second by one of the two 1‐acyl‐sn‐glycerol‐3‐phosphate acyltransferases Slc1p and Ale1p/Slc4p. To study the biogenesis and topology of Gpt2p we observed the location of dual topology reporters inserted after various transmembrane helices. Moreover, using microsomes, we probed the accessibility of natural and substituted cysteine residues to a membrane impermeant alkylating agent and tested the protease sensitivity of various epitope tags inserted into Gpt2p. Finally, we assayed the sensitivity of the acyltransferase activity to membrane impermeant agents targeting lysine residues. By all these criteria we find that the most conserved motifs of Gpt2p and its functionally relevant lysines are oriented towards the ER lumen. Thus, the first step in biosynthesis of phosphatidic acid in yeast seems to occur in the ER lumen and substrates may have to cross the ER membrane.
Sandpile behaviour in discrete water-wave turbulence

I construct a sandpile model for the evolution of the energy spectrum of water waves in finite basins. This model takes into account loss of resonant wave interactions in discrete Fourier space and restoration of these interactions at larger nonlinearity levels. For weak forcing, the wave action spectrum takes a critical ω−10 shape where the nonlinear resonance broadening overcomes the effect of the Fourier grid spacing. The energy cascade in this case takes the form of rare weak avalanches on the critical slope background. For larger forcing, this regime is replaced by a continuous cascade and a Zakharov–Filonenko ω−8 wave action spectrum. For intermediate forcing levels, both scalings will be relevant, ω−10 at small frequencies and ω−8 at large frequencies, with a transitional region in between, characterized by strong avalanches.
Outcome of Orthoses Intervention in the Rheumatoid Foot

This study was carried out to determine the effect of foot orthoses on pain, gait, and energy expenditure in patients with rheumatoid arthritis. Eighteen patients were evaluated for these parameters. Each patient was given a foot insert or shoe modification suitable for his or her foot deformity. Following 3 months of orthosis use, a significant difference was found in regards to pain (p <.05), step length and stride length (p <.05), and physiological cost index (p <.05). The results suggest that foot orthoses are an important feature in the rehabilitation of the rheumatoid foot.
Leishmania amazonensis Arginase Compartmentalization in the Glycosome Is Important for Parasite Infectivity

In Leishmania, de novo polyamine synthesis is initiated by the cleavage of L-arginine to urea and L-ornithine by the action of arginase (ARG, E.C. 3.5.3.1). Previous studies in L. major and L. mexicana showed that ARG is essential for in vitro growth in the absence of polyamines and needed for full infectivity in animal infections. The ARG protein is normally found within the parasite glycosome, and here we examined whether this localization is required for survival and infectivity. First, the localization of L. amazonensis ARG in the glycosome was confirmed in both the promastigote and amastigote stages. As in other species, arg− L. amazonensis required putrescine for growth and presented an attenuated infectivity. Restoration of a wild type ARG to the arg − mutant restored ARG expression, growth and infectivity. In contrast, restoration of a cytosol-targeted ARG lacking the glycosomal SKL targeting sequence (argΔSKL) restored growth but failed to restore infectivity. Further study showed that the ARGΔSKL protein was found in the cytosol as expected, but at very low levels. Our results indicate that the proper compartmentalization of L. amazonensis arginase in the glycosome is important for enzyme activity and optimal infectivity. Our conjecture is that parasite arginase participates in a complex equilibrium that defines the fate of L-arginine and that its proper subcellular location may be essential for this physiological orchestration.
Can Housing Risk Be Diversified? A Cautionary Tale from the Housing Boom and Bust

This study evaluates the effectiveness of geographic diversification in reducing housing investment risk. To characterize diversification potential, we estimate spatial correlation and integration among 401 US metropolitan housing markets. The 2000s boom brought a marked uptrend in housing market integration associated with eased residential lending standards and rapid growth in private mortgage securitization. As boom turned to bust, macro factors, including employment and income fundamentals, contributed importantly to the trending up in housing return integration. Portfolio simulations reveal substantially lower diversification potential and higher risk in the wake of increased market integration.
SoC implementation issues for synthesizable embedded programmable logic cores

As integrated circuits have become more and more complex, the ability to make post-fabrication changes will become more and more attractive. This ability can be realized using programmable logic cores. Currently, such cores are available from vendors in the form of a "hard" layout. An alternative approach is to use a "soft", or synthesizable programmable logic core that can be synthesized using standard library cells. In this paper, we describe the design of an integrated circuit that incorporates such a synthesizable programmable logic core. We focus on implementation issues that arose; specifically, the choice of core size, the connection of the core to the rest of the integrated circuit, and clock tree synthesis. We also present area and delay overhead results.
Numerical Analysis of Subsoil-Reinforced Concrete Slab Interaction

This article presents the numerical modeling of interaction between a reinforced concrete slab and subsoil using ABAQUS. Subsoil was simulated as both homogeneous half-space and inhomogeneous half-space. Reinforcement bars in the concrete slab were accurately modelled allowing capturing a precise deformation profile of the slab in interaction with subsoil. Input data for numerical analysis were adopted from a published work. Results of the study were verified on the basis of comparison with those of the previous study.
Safety and effectiveness of collagenase clostridium histolyticum in the treatment of Peyronie's disease using a new modified shortened protocol

To evaluate the efficacy and safety of collagenase clostridium histolyticum (CCH; Xiapex®, Xiaflex®) in the treatment of Peyronie's disease (PD) using a new modified treatment protocol that aims at reducing the number of injections needed and reducing patient visits, thus reducing the duration and cost of treatment.