Miracle-dz/UniFAR-FTUs huggingface dataset:
Role of the 5.8S rRNA in ribosome translocation.

Studies on the inhibition of protein synthesis by specific anti 5.8S rRNA oligonucleotides have suggested that this RNA plays an important role in eukaryotic ribosome function. Mutations in the 5. 8S rRNA can inhibit cell growth and compromise protein synthesis in vitro . Polyribosomes from cells expressing these mutant 5.8S rRNAs are elevated in size and ribosome-associated tRNA. Cell free extracts from these cells also are more sensitive to antibiotics which act on the 60S ribosomal subunit by inhibiting elongation. The extracts are especially sensitive to cycloheximide and diphtheria toxin which act specifically to inhibit translocation. Studies of ribosomal proteins show no reproducible changes in the core proteins, but reveal reduced levels of elongation factors 1 and 2 only in ribosomes which contain large amounts of mutant 5.8S rRNA. Polyribosomes from cells which are severely inhibited, but contain little mutant 5.8S rRNA, do not show the same reductions in the elongation factors, an observation which underlines the specific nature of the change. Taken together the results demonstrate a defined and critical function for the 5.8S rRNA, suggesting that this RNA plays a role in ribosome translocation.
World Journal of Emergency Surgery Open Access Decision Making in Patients with Acute Abdominal Pain at a University and at a Rural Hospital: Does the Value of Abdominal Sonography Differ?

Introduction and objectives: Abdominal sonography is regarded as a quick and effective diagnostic tool for acute abdominal pain in emergency medicine. However, final diagnosis is usually based on a combination of various clinical examinations and radiography. The role of sonography in the decision making process at a hospital with advanced imaging capabilities versus a hospital with limited imaging capabilities but more experienced clinicians is unclear.
The Proliferative Inhibition and Apoptotic Mechanism of Saikosaponin D in Human Non-Small Cell Lung Cancer A549 Cells

Saikosaponin D is a saponin extract derived from several species of Bupleurum (Umbelliferae), which is used for the treatment of various liver diseases in traditional Chinese medicine. In this study, we report that Saikosaponin D inhibits the cell growth of human lung cancer cell line A549 and provide a molecular understanding of this effect. The results showed that Saikosaponin D inhibited the proliferation of A549 by inducing apoptosis and blocking cell cycle progression in the G1 phase. ELISA assay showed that Saikosaponin D significantly increased the expression of p53 and p21/WAFl protein, contributing to cell cycle arrest. An enhancement in Fas/APO-1 and its two form ligands, membrane-bound Fas ligand (mFasL) and soluble Fas ligand (sFasL), as well as Bax protein, was responsible for the apoptotic effect induced by Saikosaponin D. Taken together, our study suggests that the induction of p53 and activity of the Fas/FasL apoptotic system may participate in the antiproliferative activity of Saikosaponin D in A549 cells.
Classification of gait disorders Gait disorder Cautious gait Disequilibrium syndrome Isolated gait ignition failure Frontal gait disorder

Gait disturbance is common in patients with Alzheimer's disease (AD). The aim of this study was to analyse the clinical gait syndromes of patients with AD using Nutt's classification. Fifty-five patients who satisfied the NINCDS-ADRDA criteria for probable AD and 55 controls were recruited from a geriatric and a psychogeriatric unit. Patients with classical musculoskeletal or neurological syndromes causing gait disturbance were excluded. A standardized neurological examination was carried out in all subjects. Twenty-two (40%) patients and ten (18%) controls had a higher level gait disorder (p < 0.01). The pattern of gait disturbance in AD patients varied according to the stage of the disease. Cautious gait was the commonest gait disorder in AD patients with mild dementia, while frontal gait disorder was the commonest disturbance in patients with severe dementia. The prevalence of frontal release signs (gegenhalten or any primitive reflex) was highest among patients with frontal gait disorder.
Dopamine D3 Receptor Agonist Delivery to a Model of Parkinson's Disease Restores the Nigrostriatal Pathway and Improves Locomotor Behavior

The presence of endogenous stem cell populations in the adult mammalian CNS suggests an innate potential for regeneration and represents a potential resource for neuroregenerative therapy aimed at the treatment of neurodegenerative disorders, such as Parkinson's disease. However, it is first necessary to examine the microenvironmental signals required to activate these innate reparative mechanisms. The small molecule neurotransmitter dopamine has been shown to regulate cell cycle in developing and adult brain, and the D3 receptor is known to play an important role in dopaminergic development. Pharmacological activation of the dopamine D3 receptor has been shown to trigger neurogenesis in the substantia nigra of the adult rat brain. Here, we examined the cell proliferative, neurogenic, and behavioral effects of the dopamine D3 receptor agonist 7-OH-DPAT (7-hydroxy-N,N-di-n-propyl-2-aminotetralin) in a 6-hydroxydopamine model of Parkinson's disease. Consistent with previous findings, we observed a significant induction of cell proliferation in the substantia nigra pars compacta (SNC) with a time-dependent adoption of a neuronal dopaminergic phenotype in many of these cells. Indices of nigrostriatal integrity were also affected. Dopaminergic cell counts in the lesioned SNC recovered substantially in a time-dependent manner. Similarly, retrograde tracing revealed a restoration of striatal innervation from these cells, with evidence for projections arising from newly generated cells. Finally, we observed a substantial and persistent recovery of locomotor function in these animals. The results of these studies will further our understanding of the environmental signals regulating neurogenesis in the adult brain and could have significant implications for the design of novel treatment strategies for Parkinson's disease.
Hardware implementation of MRF map inference on an FPGA platform

In this paper, we describe hardware for inference computations on Markov Random Fields (MRFs). MRFs are widely used in applications like computer vision, but conventional software solvers are slow. Belief Propagation (BP) solvers, which use patterns of local message passing on MRFs, have been studied in hardware, but their performance is unreliable. We show how a superior method-Sequential Tree-Reweighted message passing (TRW-S)-can be rendered in hardware. TRW-S has reliable convergence, guaranteed by its so-called “sequential” computation. Analysis reveals many opportunities for TRW-S hardware acceleration. We show how to implement TRW-S in FPGA hardware so that it exploits significant parallelism and memory bandwidth. Our implementation is capable of running a standard stereo vision benchmark at rates approaching 40 frames/sec; this represents the first time TRW-S methods have been accelerated to these speeds on an FPGA platform.
Weighted hybrid clustering by combining text mining and bibliometrics on a large-scale journal database

We propose a new hybrid clustering framework to incorporate text mining with bibliometrics in journal set analysis.The framework integrates two different approaches: clustering ensemble and kernel-fusion clustering. To improve the flexibility and the efficiency of processing large-scale data, we propose an information-based weighting scheme to leverage the effect of multiple data sources in hybrid clustering. Three different algorithms are extended by the proposed weighting scheme and they are employed on a large journal set retrieved from the Web of Science (WoS) database. The clustering performance of the proposed algorithms is systematically evaluated using multiple evaluation methods, and they were cross-compared with alternative methods. Experimental results demonstrate that the proposed weighted hybrid clustering strategy is superior to other methods in clustering performance and efficiency. The proposed approach also provides a more refined structural mapping of journal sets, which is useful for monitoring and detecting new trends in different scientific fields.
Multiple distributions for biased random test patterns

An efficient method has been presented to compute multiple distributions for random patterns, which can be applied successively. Using multiple distributions, all combinational circuits can be made random-testable, and complete fault coverage is provided by a few thousands of random patterns. The differently weighted random test sets can be applied to scan path circuits using an external chip, combining the advantages of a low cost test and of high fault coverage. Several facts about testing by random patterns have been proven. It has been shown that the number of random patterns required for a certain fault coverage can be computed without regarding the pseudorandom property and with the independence assumption for fault detection. <<ETX>>
Risk Management and Healthcare Policy Dovepress Psychosocial Support and Parents' Social Life Determine the Self-esteem of Orphan Children

Parental death affects the life of children in many ways, one of which is self-esteem problems. Providing psychosocial support and equipping orphans play a vital role in their lifes. A cross-sectional study was conducted on 7–18-year-old orphans at 17 local districts of Gamo Gofa Zone, Southern Regional State of Ethiopia. From a total of 48,270 orphans in these areas, 4,368 were selected using stratified simple random sampling technique. Data were collected with a designed questionnaire based on the Rosenberg's rating scale to measure their self-esteem levels. Self-esteem with a score less than or equal to an average score was considered to be low self-esteem in the analysis. Binary logistic regression model was used to analyze the data using the SPSS software. The results of the study revealed that the probability of orphans suffering from low self-esteem was 0.59. Several risk factors were found to be significant at the level of 5%. Psychosocial support (good guidance, counseling and treatment, physical protection and amount of love shared, financial and material support, and fellowship with other children), parents living together before death, strong relationship between parents before death, high average monthly income, voluntary support, and consideration from the society are some of the factors that decrease the risk of being low in self-esteem. There are many orphans with low self-esteem in the study areas. The factors negatively affecting the self-esteem of orphans include the lack of psychosocial support, poor social life of parents, and death of parents due to AIDS. Society and parents should be aware of the consequences of these factors which can influence their children's future self-esteem.
Long-Term Results of Allograft Replacement in the Management of Bone Tumors

Over the past 24 years, the authors have implanted >870 massive frozen cadaveric allografts mostly for the treatment of defects created by the resection of a bone tumor. Most of the grafts were obtained from the authors' institutional bone bank. The results show that only stage and type of graft affected outcome predictably. Specifically, grafts for a Stage 2 or Stage 3 tumor had a poorer outcome than those for Stages 0 and 1. The results for allograft arthrodeses were considerably poorer than osteoarticular, intercalary, and allograft plus prosthesis. The other major factors in results were complications-recurrence, infection, fracture, and nonunion-with the former 2 having a profound negative effect on outcome. After the first year of susceptibility to infection (10%) and the third year of increased risk of fracture (19%), the grafts become stable, and approximately 75% are retained by patients and are considered to be successful for >20 years after implantation. Osteoarthritis becomes a problem at approximately 6 years for osteoarticular grafts, and so far, 16% of the patients with distal femoral, proximal tibial, or proximal femoral grafts have required total joint replacements. Although the current results are adequate, they are imperfect, and research should be directed at improving the results.
Extraction of shady roads using intrinsic colors on stereo camera

This paper addresses the problem of extracting the road region in different driving environments with dynamic lighting changes, for driver-assistance applications. In this paper, we propose a stereo visual sensor system and a vision-based road extraction method in a new color space. The color space is designed such that it is representative of intrinsic reflectance of the road surface, and independent of illumination source. Our basic model of road color is a mixture of Gaussians in that color space, constructed from road sample pixels. Those color samples are reliably collected from stereo-verified ground patches inside a pre-defined trapezoidal learning region. The advantages of this system with respect to other systems are that it is more economical for driver-assistance applications while giving robust results and, in particular, recognizing shadows on road as drivable road surface instead of non-road.
Chromosomes of two Australian lizards of the families Scincidae and Gekkonidae.

Karyotypic studies of the Scincidae and Gekkonidae are not plentiful. Naka mura (1931), Asana and Mahabale (1941), Makino and Momma (1949), Matthey (1949) and Dallai and Talluri (1969) have karyotyped some 10 species of the Scin cidae. Sixteen species of the family Gekkonidae have also been examined (Mat they 1931, 1933, Nakamura 1932, Asana and Mahabale 1941, Makino and Momma 1949, Matthey 1949, Werner 1956, Cohen et al. 1967, Kluge and Eckardt 1969). Much of the earlier work, however, is lacking in accurate karyotype data due to the many technical difficulties encountered. In the suborder Sauria, most families which have been studied chromosomally are reported to have microchromosomes. These include the Agamidae, Iguanidae, Amphisbaenidae and Varanidae (Matthey 1949, Gorman 1965, Gorman and At kins 1966, Gorman et al. 1967, Huang et al. 1967, Cohen et al. 1967, Pennock et al. 1969, Dutt 1969). On the other hand, it has been suggested that the Scincidae and Gekkonidae are families characterized by the absence of microchromosomes (Mat they 1949, Cohen et al. 1967). The present study establishes the presence of micro chromosomes in two species from these families. The chromosome number and karyotype morphology of these species (Tiliqua rugosa, Scincidae and Diplodactylus tessellatus, Gekkonidae) are also reported.
Psychological Stress and Recurrent Aphthous Stomatitis

INTRODUCTION AND OBJECTIVES: Recurrent aphthous stomatitis (RAS) is the most common type of ulcerative disease of the oral mucosa. Despite its worldwide occurrence and the extensive amount of research that has been devoted to the subject, the etiology of RAS remains unclear. Nevertheless, several hereditary, nutritional, infectious and psychological factors have been associated with RAS. The aim of this case-control study was to assess the influence of psychological stress on the manifestation of RAS. METHOD: Fifty patients were enrolled in the trial. Twenty-five RAS patients constituted the study group and another 25 non-RAS patients who were similarly matched for sex, age and socioeconomic status constituted the control group. Each patient was evaluated in terms of the four domains of stress (emotional, physical, social and cognitive) using an internationally validated questionnaire, which was comprised of 59 items and measured the frequency and intensity of stress symptoms. The RAS group was interviewed during an active RAS episode. Completed questionnaires were submitted to proper analytical software and interpreted by an expert psychologist. RESULTS: There was a higher level of psychological stress among RAS group patients when compared to the control group (P < 0.05). CONCLUSION: Psychological stress may play a role in the manifestation of RAS; it may serve as a trigger or a modifying factor rather than being a cause of the disease.
Modelling epidermis homoeostasis and psoriasis pathogenesis

We present a computational model to study the spatio-temporal dynamics of epidermis homoeostasis under normal and pathological conditions. The model consists of a population kinetics model of the central transition pathway of keratinocyte proliferation, differentiation and loss and an agent-based model that propagates cell movements and generates the stratified epidermis. The model recapitulates observed homoeostatic cell density distribution, the epidermal turnover time and the multilayered tissue structure. We extend the model to study the onset, recurrence and phototherapy-induced remission of psoriasis. The model considers psoriasis as a parallel homoeostasis of normal and psoriatic keratinocytes originated from a shared stem cell (SC) niche environment and predicts two homoeostatic modes of psoriasis: a disease mode and a quiescent mode. Interconversion between the two modes can be controlled by interactions between psoriatic SCs and the immune system and by normal and psoriatic SCs competing for growth niches. The prediction of a quiescent state potentially explains the efficacy of multi-episode UVB irradiation therapy and recurrence of psoriasis plaques, which can further guide designs of therapeutics that specifically target the immune system and/or the keratinocytes.
Proper extensions of Noether's symmetry theorem for nonsmooth extremals of the calculus of variations

For nonsmooth Euler-Lagrange extremals, Noether's conservation laws cease to be valid. We show that Emmy Noether's theorem of the calculus of variations is still valid in the wider class of Lipschitz functions, as long as one restrict the Euler-Lagrange extremals to those which satisfy the DuBois-Reymond necessary condition. In the smooth case all Euler-Lagrange extremals are DuBois-Reymond extremals, and the result gives a proper extension of the classical Noether's theorem. This is in contrast with the recent developments of Noether's symmetry theorems to the optimal control setting, which give rise to non-proper extensions when specified for the problems of the calculus of variations. Results are also obtained for variational problems with higher-order derivatives.
Effectiveness of computer ergonomics interventions for an engineering company: a program evaluation.

OBJECTIVE Ergonomic principles at the computer workstation may reduce the occurrence of work related injuries commonly associated with intensive computer use. A program implemented in 2001 by an occupational therapist and a physical therapist utilized these preventative measures with education about ergonomics, individualized evaluations of computer workstations, and recommendations for ergonomic and environmental changes. METHOD This study examined program outcomes and perceived effectiveness based on review of documents, interviews, and surveys of the employees and the plant manager. RESULTS The program was deemed successful as shown by 59% of all therapist recommendations and 74% of ergonomic recommendations being implemented by the company, with an 85% satisfaction rate for the ergonomic interventions and an overall employee satisfaction rate of 70%. Eighty-one percent of the physical problems reported by employees were resolved to their satisfaction one year later. CONCLUSION Successful implementation of ergonomics programs depend upon effective communication and education of the consumers, and the support, cooperation and collaboration of management and employees.
Synaptic depression and slow oscillatory activity in a biophysical network model of the cerebral cortex

Short-term synaptic depression (STD) is a form of synaptic plasticity that has a large impact on network computations. Experimental results suggest that STD is modulated by cortical activity, decreasing with activity in the network and increasing during silent states. Here, we explored different activity-modulation protocols in a biophysical network model for which the model displayed less STD when the network was active than when it was silent, in agreement with experimental results. Furthermore, we studied how trains of synaptic potentials had lesser decay during periods of activity (UP states) than during silent periods (DOWN states), providing new experimental predictions. We next tackled the inverse question of what is the impact of modifying STD parameters on the emergent activity of the network, a question difficult to answer experimentally. We found that synaptic depression of cortical connections had a critical role to determine the regime of rhythmic cortical activity. While low STD resulted in an emergent rhythmic activity with short UP states and long DOWN states, increasing STD resulted in longer and more frequent UP states interleaved with short silent periods. A still higher synaptic depression set the network into a non-oscillatory firing regime where DOWN states no longer occurred. The speed of propagation of UP states along the network was not found to be modulated by STD during the oscillatory regime; it remained relatively stable over a range of values of STD. Overall, we found that the mutual interactions between synaptic depression and ongoing network activity are critical to determine the mechanisms that modulate cortical emergent patterns.
Microbiological aspects of peritonitis in patients on continuous ambulatory peritoneal dialysis

The objective of the study was to identify the microbiological spectrum and drug-sensitivity pattern of peritonitis in patients on continuous ambulatory peritoneal dialysis. This was a prospective study done over a period of a year-and-a-half at a tertiary-care hospital in a hilly state of India. The effluent dialysate bags from 36 consecutive patients with peritonitis were studied. One hunderd ml dialysate fluid was processed under aseptic conditions by lysis centrifugation method. Microscopy and culture was done from the deposits for bacteriological, fungal, and mycobacterial isolates. They were identified by colony morphology and their biochemical reactions. Drug susceptibility testing was done by Kirby-Bauer disc diffusion method. In 36 dialysates, 33 (91.6%) dialysates were culture-positive and in 3 (8.4%), the culture was negative. A total of 36 microorganisms were isolated in 33 cultures. Among the 36 microorganisms, 19 (52.8%) isolates were gram-positive, 10 (27.8%) were gram-negative, 5 (13.9%) were fungi, and 2 (5.6%) were mycobacterial isolates. All gram-positive organisms were sensitive to ampicillin, amoxi-clavulanic acid, cefazolin, clindamycin, and vancomycin. Neither a methicillin-resistant Staphylococci aureus nor a vancomycin-resistant Enterococcus was isolated in gram-positive isolates. Gram-negative organisms were sensitive to ciprofloxacin, ceftriaxone, ceftazidime, cefepime, gentamicin, piperacillin–tazobactam and imipenem. One of the gram-negative isolate was an extended spectrum beta-lactamase producer. Gram-positive peritonitis was more frequent than gram-negative peritonitis in our continuous ambulatory peritoneal dialysis patients. Mycobacterial causes were responsible for peritonitis in patients with culture-negative peritonitis which was not responding to the conventional antimicrobial therapy.