Miracle-dz/UniFAR-FTUs huggingface dataset:
Short-term effects of air pollution on a range of cardiovascular events in England and Wales: case-crossover analysis of the MINAP database, hospital admissions and mortality

Objective To inform potential pathophysiological mechanisms of air pollution effects on cardiovascular disease (CVD), we investigated short-term associations between ambient air pollution and a range of cardiovascular events from three national databases in England and Wales. Methods Using a time-stratified case-crossover design, over 400 000 myocardial infarction (MI) events from the Myocardial Ischaemia National Audit Project (MINAP) database, over 2 million CVD emergency hospital admissions and over 600 000 CVD deaths were linked with daily mean concentrations of carbon monoxide (CO), nitrogen dioxide (NO2), particulate matter less than 10 μm in aerodynamic diameter (PM10), particulate matter less than 2.5 μm in aerodynamic diameter (PM2.5) and sulfur dioxide (SO2), and daily maximum of 8-hourly running mean of O3 measured at the nearest air pollution monitoring site to the place of residence. Pollutant effects were modelled using lags up to 4 days and adjusted for ambient temperature and day of week. Results For mortality, no CVD outcome analysed was clearly associated with any pollutant, except for PM2.5 with arrhythmias, atrial fibrillation and pulmonary embolism. With hospital admissions, only NO2 was associated with a raised risk: CVD 1.7% (95% CI 0.9 to 2.6), non-MI CVD 2.0% (1.1 to 2.9), arrhythmias 2.9% (0.6 to 5.2), atrial fibrillation 2.8% (0.3 to 5.4) and heart failure 4.4% (2.0 to 6.8) for a 10th–90th centile increase. With MINAP, only NO2 was associated with an increased risk of MI, which was specific to non-ST-elevation myocardial infarction (non-STEMIs): 3.6% (95% CI 0.4 to 6.9). Conclusions This study found no clear evidence for pollution effects on STEMIs and stroke, which ultimately represent thrombogenic processes, though it did for pulmonary embolism. The strongest associations with air pollution were observed with selected non-MI outcomes.
Social support, occupational stress, and health.

The present paper is concerned with the buffering hypothesis that social support ameliorate. the impact of occupational stress on job-related strain and health. Previous studies of this hypothesis have yielded conflicting results. Our purpose, therefore, is twofold. First, we summarize the literature in this area and review several studies in detail, all of which found main effects of social support on perceived occupational stress and on some health outcome measures. Three of the studies were specifically designed to examine the buffering effects of support. Of the three, two found little or no evidence for buffering (LaRocco and Jones, 1978a; Pinneau, 1975), whereas the third reported buffering effects (House and Wells, 1978). Second, we attempt to reconcile these different conclusions by reanalyzing one data set-first analyzed by Caplan et al. (1975) and then by Pinneau (1975)-using a moderated regression technique identical to that used in the LaRocco and Jones (1978a) and House and Wells (1978) studies. The data usedfor this analysis consist of a randomly stratified sample of men from 23 occupations (N 636). Our review andfindings support the buffering hypothesis for mental and physical health variables (anxiety, depression, irritation, and somatic symptoms), but, as in the previous three studies, fail to support the buffering hypothesis in regard to job-related strains (job dissatisfaction, boredom, dissatisfaction with work load).
Unmet Health Care Needs Among CSHCN With Neurologic Conditions

OBJECTIVE Children with neurologic conditions require a variety of services. With this study we examined health care needs and unmet needs among children with neurologic conditions. METHODS Cross-sectional data reported by parents of 3-to 17-year-olds in the 2005–2006 National Survey of Children With Special Health Care Needs were analyzed. Demographic characteristics, health care needs, and unmet needs of children with special health care needs (CSHCN) and neurologic conditions were descriptively compared with an independent referent group of children without special health care needs; statistical contrasts were performed as a function of the type (conditions included in the Diagnostic and Statistical Manual of Mental Disorders [DSM] or not) and number of reported neurologic conditions. RESULTS Compared with the parents of children without special health care needs, parents of CSHCN with neurologic conditions were more likely to report unmet health care needs for their child. After adjustment for demographic factors and severity of functional limitation, CSHCN with at least 2 conditions had more visits to a health care provider, needed more services, and reported more unmet needs than CSHCN with a single DSM condition. The magnitude of need among CSHCN was greatest among those with at least 1 of each type of neurologic condition. CONCLUSIONS Unmet health care needs exist among CSHCN with neurologic conditions and are particularly pronounced among children with a combination of both DSM and non-DSM disorders. The health care needs among CSHCN with multiple neurologic conditions may be better served by targeted efforts to improve care coordination.
Extraction of gate level models from transistor circuits by four-valued symbolic analysis

The program TRANALYZE generates a gate-level representation of an MOS transistor circuit. The results model contains only four-valued unit and zero delay logic primitives, suitable for evaluation by conventional gate-level simulators and hardware simulation accelerators. TRANALYZE has the same generality and accuracy as switch-level simulation, generating models for a wide range of technologies and design styles, while expressing the detailed effects of bidirectional transistors, stored charge, and multiple signal strengths. It produces models with size comparable to ones generated by hand. <<ETX>>
Relationships among ecologically important dimensions of plant trait variation in seven neotropical forests.

BACKGROUND AND AIMS When ecologically important plant traits are correlated they may be said to constitute an ecological 'strategy' dimension. Through identifying these dimensions and understanding their inter-relationships we gain insight into why particular trait combinations are favoured over others and into the implications of trait differences among species. Here we investigated relationships among several traits, and thus the strategy dimensions they represented, across 2134 woody species from seven Neotropical forests. METHODS Six traits were studied: specific leaf area (SLA), the average size of leaves, seed and fruit, typical maximum plant height, and wood density (WD). Trait relationships were quantified across species at each individual forest as well as across the dataset as a whole. 'Phylogenetic' analyses were used to test for correlations among evolutionary trait-divergences and to ascertain whether interspecific relationships were biased by strong taxonomic patterning in the traits. KEY RESULTS The interspecific and phylogenetic analyses yielded congruent results. Seed and fruit size were expected, and confirmed, to be tightly related. As expected, plant height was correlated with each of seed and fruit size, albeit weakly. Weak support was found for an expected positive relationship between leaf and fruit size. The prediction that SLA and WD would be negatively correlated was not supported. Otherwise the traits were predicted to be largely unrelated, being representatives of putatively independent strategy dimensions. This was indeed the case, although WD was consistently, negatively related to leaf size. CONCLUSIONS The dimensions represented by SLA, seed/fruit size and leaf size were essentially independent and thus conveyed largely independent information about plant strategies. To a lesser extent the same was true for plant height and WD. Our tentative explanation for negative WD-leaf size relationships, now also known from other habitats, is that the traits are indirectly linked via plant hydraulics.
Molecular mechanisms of genetic variation and transcriptional regulation of CYP2C19

Inherited variation in the function of the drug metabolizing enzyme CYP2C19 was first observed 40 years ago. The SNP variants which underpin loss of CYP2C19 function have been elucidated and extensively studied in healthy populations. However, there has been relatively meagre translation of this information into the clinic. The presence of genotype-phenotype discordance in certain patients suggests that changes in the regulation of this gene, as well as loss of function SNPs, could play a role in deficient activity of this enzyme. Knowledge of the molecular mechanisms which control transcription of this gene, reviewed in this article, may aid the challenge of delivering CYP2C19 pharmacogenetics into clinical use.
Thermal Protective Performance of Silica AerogelFelt bedded Firefighters’ Protective Clothing under Fire Conditions

The addition of silica aerogel felt (SAF) to firefighters’ protective clothing (FPC) is an innovation with the potential to enhance the thermal insulation capacity of FPC. In order to explore this technology, this paper describes the results of an experiment that determined the thermal protective performance of FPC with SAF under wood crib fire conditions. We also performed an experiment using FPC materials without SAF and compared the results. Finally, we compared the thermal decomposition of commercial thermal liner material and silica aerogel. The results demonstrate that the thermal performance of SAF bedded sample is better than that without. The maximum temperature difference was about 20 °C. The thermal performance of SAF bedded sample increased with increasing the SAF thick. Additionally, the thermal stability of silica aerogel is good, which can reduce the risk of thermal decomposition during high temperatures.
The Subsequence Composition of Polypeptides

The quantitative underpinning of the information content of biosequences represents an elusive goal and yet also an obvious prerequisite to the quantitative modeling and study of biological function and evolution. Several past studies have addressed the question of what distinguishes biosequences from random strings, the latter being clearly unpalatable to the living cell. Such studies typically analyze the organization of biosequences in terms of their constituent characters or substrings and have, in particular, consistently exposed a tenacious lack of compressibility on behalf of biosequences. This article attempts, perhaps for the first time, an assessement of the structure and randomness of polypeptides in terms on newly introduced parameters that relate to the vocabulary of their (suitably constrained) subsequences rather than their substrings. It is shown that such parameters grasp structural/functional information, and are related to each other under a specific set of rules that span biochemically diverse polypeptides. Measures on subsequences separate few amino acid strings from their random permutations, but show that the random permutations of most polypeptides amass along specific linear loci.
Clinical Features of Fitz-Hugh-Curtis Syndrome in the Emergency Department

Purpose Fitz-Hugh-Curtis Syndrome (FHCS) is a clinical entity characterized by inflammation of the liver capsule associated with genital tract infection. The aim of this study is to provide physicians with clinical suggestions for diagnostic approaches based on a series of patients who were diagnosed with FHCS. Materials and Methods We conducted a retrospective study of patients who were diagnosed with FHCS after presenting to the emergency department (ED). The symptoms, physical examinations, laboratory findings, radiological findings, and progress of the patients were reviewed. Results During the four-year study period, a total of 82 female patients received a final diagnosis of FHCS in the ED. Chlamydia trachomatis was identified as a pathogen in 89% of the patients. Their clinical characteristics and laboratory findings were described. Fifty-two patients (63.4%) were admitted to the hospital. All of the admitted patients improved after treatment combining antibiotic therapy with conservative care. Conclusion FHCS should be considered as a differential diagnosis for female patients of childbearing age with right upper abdominal pain. Timely diagnosis using biphasic computed tomography (CT) with arterial and portal phases may help ensure adequate medical treatment as well as avoid invasive procedures.
Optimizing Big Data in Bioinformatics with Swarm Algorithms

This paper describes the application of swarm algorithms on bioinformatics data namely protein sequences. The big data that exists in bioinformatics domains require an intelligent method that capable to increase the performance of classification as well as discovering the knowledge. The work optimizes the big features that exist in protein sequences using the two-tier hybrid model by applying the filter and wrapper method. The use of swarm algorithm namely particle swarm optimization has improved the classification accuracy as the features are optimized prior to classification. The study also compares the performance of swarm algorithms with the standard searching method.
Neurodevelopmental and functional outcomes of extremely low birth weight infants in the National Institute of Child Health and Human Development Neonatal Research Network, 1993-1994.

OBJECTIVES The purposes of this study were to report the neurodevelopmental, neurosensory, and functional outcomes of 1151 extremely low birth weight (401-1000 g) survivors cared for in the 12 participating centers of the National Institute of Child Health and Human Development Neonatal Research Network, and to identify medical, social, and environmental factors associated with these outcomes. STUDY DESIGN A multicenter cohort study in which surviving extremely low birth weight infants born in 1993 and 1994 underwent neurodevelopmental, neurosensory, and functional assessment at 18 to 22 months' corrected age. Data regarding pregnancy and neonatal outcome were collected prospectively. Socioeconomic status and a detailed interim medical history were obtained at the time of the assessment. Logistic regression models were used to identify maternal and neonatal risk factors for poor neurodevelopmental outcome. RESULTS Of the 1480 infants alive at 18 months of age, 1151 (78%) were evaluated. Study characteristics included a mean birth weight of 796 +/- 135 g, mean gestation (best obstetric dates) 26 +/- 2 weeks, and 47% male. Birth weight distributions of infants included 15 infants at 401 to 500 g; 94 at 501 to 600 g; 208 at 601 to 700 g; 237 at 701 to 800 g; 290 at 801 to 900 g; and 307 at 901 to 1000 g. Twenty-five percent of the children had an abnormal neurologic examination, 37% had a Bayley II Mental Developmental Index <70, 29% had a Psychomotor Developmental Index <70, 9% had vision impairment, and 11% had hearing impairment. Neurologic, developmental, neurosensory, and functional morbidities increased with decreasing birth weight. Factors significantly associated with increased neurodevelopmental morbidity included chronic lung disease, grades 3 to 4 intraventricular hemorrhage/periventricular leukomalacia, steroids for chronic lung disease, necrotizing enterocolitis, and male gender. Factors significantly associated with decreased morbidity included increased birth weight, female gender, higher maternal education, and white race. CONCLUSION ELBW infants are at significant risk of neurologic abnormalities, developmental delays, and functional delays at 18 to 22 months' corrected age.
Warning Reliability and Driver Performance in Naturalistic Driving

Objective: This study examines how naturalistic driving performance is influenced by the perceived reliability of an in-vehicle warning system using a unique measure of perceived reliability. Background: Prior studies of warning reliability conducted in simulator and test-track experiments demonstrate that the objective reliability of a warning can influence a driver's responsiveness to that warning. Methods: Driver responses to lateral drift warnings (LDWs) were examined to determine if the latency to initiate a corrective steering response was related to the subjective reliability of prior system performance. An operational definition of subjective reliability was developed based on measures of the proportion of LDWs responded to by a steering correction in the preceding 24-hr period — the day proportion. Age, gender, weather condition, light level, road class, weekday status, and day proportion were used to model correction latency in a linear model. Results: A main effect of day proportion was found, suggesting that reaction time to respond decreases by about 375 ms as the day proportion increases from 0 to 1. Conclusion: The study illustrates a method of quantifying subjective reliability and performance using naturalistic data. The results suggest that latency to make a steering correction is inversely related to the perceived reliability of the warning system in the 24 hr preceding the warning. Application: The results have direct application to the method of assessing the efficacy of in-vehicle collision warning systems, suggesting that use of a perceived reliability measure may better predict a driver's disposition to respond to a warning.
Global Transcriptional Responses of the Toxic Cyanobacterium, Microcystis aeruginosa, to Nitrogen Stress, Phosphorus Stress, and Growth on Organic Matter

Whole transcriptome shotgun sequencing (RNA-seq) was used to assess the transcriptomic response of the toxic cyanobacterium Microcystis aeruginosa during growth with low levels of dissolved inorganic nitrogen (low N), low levels of dissolved inorganic phosphorus (low P), and in the presence of high levels of high molecular weight dissolved organic matter (HMWDOM). Under low N, one third of the genome was differentially expressed, with significant increases in transcripts observed among genes within the nir operon, urea transport genes (urtBCDE), and amino acid transporters while significant decreases in transcripts were observed in genes related to photosynthesis. There was also a significant decrease in the transcription of the microcystin synthetase gene set under low N and a significant decrease in microcystin content per Microcystis cell demonstrating that N supply influences cellular toxicity. Under low P, 27% of the genome was differentially expressed. The Pho regulon was induced leading to large increases in transcript levels of the alkaline phosphatase phoX, the Pst transport system (pstABC), and the sphX gene, and transcripts of multiple sulfate transporter were also significantly more abundant. While the transcriptional response to growth on HMWDOM was smaller (5–22% of genes differentially expressed), transcripts of multiple genes specifically associated with the transport and degradation of organic compounds were significantly more abundant within HMWDOM treatments and thus may be recruited by Microcystis to utilize these substrates. Collectively, these findings provide a comprehensive understanding of the nutritional physiology of this toxic, bloom-forming cyanobacterium and the role of N in controlling microcystin synthesis.
Mining the plant–herbivore interface with a leafmining Drosophila of Arabidopsis

Experimental infections of Arabidopsis thaliana (Arabidopsis) with genomically characterized plant pathogens such as Pseudomonas syringae have facilitated the dissection of canonical eukaryotic defence pathways and parasite virulence factors. Plants are also attacked by herbivorous insects, and the development of an ecologically relevant genetic model herbivore that feeds on Arabidopsis will enable the parallel dissection of host defence and reciprocal resistance pathways such as those involved in xenobiotic metabolism. An ideal candidate is Scaptomyza flava, a drosophilid fly whose leafmining larvae are true herbivores that can be found in nature feeding on Arabidopsis and other crucifers. Here, we describe the life cycle of S. flava on Arabidopsis and use multiple approaches to characterize the response of Arabidopsis to S. flava attack. Oviposition choice tests and growth performance assays on different Arabidopsis ecotypes, defence‐related mutants, and hormone and chitin‐treated plants revealed significant differences in host preference and variation in larval performance across Arabidopsis accessions. The jasmonate and glucosinolate pathways in Arabidopsis are important in mediating quantitative resistance against S. flava, and priming with jasmonate or chitin resulted in increased resistance. Expression of xenobiotic detoxification genes was reduced in S. flava larvae reared on Arabidopsis jasmonate signalling mutants and increased in plants pretreated with chitin. These results and future research directions are discussed in the context of developing a genetic model system to analyse insect–plant interactions.
Tag Me Maybe: Perceptions of Public Targeted Sharing on Facebook

Social network sites allow users to publicly tag people in their posts. These tagged posts allow users to share to both the general public and a targeted audience, dynamically assembled via notifications that alert the people mentioned. We investigate people's perceptions of this mixed sharing mode through a qualitative study with 120 participants. We found that individuals like this sharing modality as they believe it strengthens their relationships. Individuals also report using tags to have more control of Facebook's ranking algorithm, and to expose one another to novel information and people. This work helps us understand people's complex relationships with the algorithms that mediate their interactions with each another. We conclude by discussing the design implications of these findings.
A bridge too far? Findings of bridging anticoagulation use and outcomes in the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF).

In the current issue of Circulation , Steinberg et al1 describe the use and outcomes associated with bridging anticoagulation (AC) in patients with atrial fibrillation (AF) in the contemporary Outcomes Registry for Better Informed Treatment of AF (ORBIT-AF). Chronic oral anticoagulation (OAC) significantly reduces the risk of stroke or thromboembolism in patients with AF. Despite the growing population burden of AF,2 the increasing use of OAC, and the frequent need for cardiac and noncardiac procedures in this population, remarkably little contemporary data exist to help guide the clinician with respect to periprocedural AC decision making. Although guidelines exist on the topic, they are based on limited and largely observational data.3,4 Current guideline-supported periprocedural AC management supports the discontinuation of OAC and the use of short-acting AC, most commonly low-molecular-weight heparin or unfractionated heparin, to bridge AF patients at high risk for thromboembolic complications during the immediate pre- and postprocedure period (American College of Chest Physicians grade 2C; American Heart Association grade 1C). 3,4 Article see p 488 “To bridge or not to bridge,” is a question often asked in clinical practice, with an estimated 250 000 patients on OAC undergoing cardiac and noncardiac procedures annually in North America.3 The authors are therefore to be congratulated for examining the topic of use and outcomes of bridging AC in an effort to better inform us and enhance the safety of our AF patients. Currently, the periprocedural management of patients who are receiving OAC is often informed by a clinician’s (1) assessment of patient risk for thromboembolism, (2) assessment of risk for perioperative bleeding, and (3) the type of procedure. Although CHADS2, CHA2DS2-VASc, HAS-BLED, and ATRIA scores are used in clinical practice to assess the risks of …