Miracle-dz/UniFAR-FTUs huggingface dataset:
Evolution of cooperation and skew under imperfect information

The evolution of cooperation in nature and human societies depends crucially on how the benefits from cooperation are divided and whether individuals have complete information about their payoffs. We tackle these questions by adopting a methodology from economics called mechanism design. Focusing on reproductive skew as a case study, we show that full cooperation may not be achievable due to private information over individuals’ outside options, regardless of the details of the specific biological or social interaction. Further, we consider how the structure of the interaction can evolve to promote the maximum amount of cooperation in the face of the informational constraints. Our results point to a distinct avenue for investigating how cooperation can evolve when the division of benefits is flexible and individuals have private information.
Unemployed citizen or ‘at risk’ client? Classification systems and employment services in Denmark and Australia

The paper explores recent developments in Australian and Danish unemployment policies with a special focus on the technologies used to classify and categorize unemployed people on government benefits. Using governmentality as our theoretical framework, we consider the implications of reducing complex social problems to statistical scores and differentiated categories — forms of knowledge that diminish the capacity to think about unemployment as a collective problem requiring collective solutions. What we argue is that classification systems, which are part and parcel of welfare state administration, are becoming more technocratic in the way in which they divide the population into different categories of risk.
The Effect of Inappropriate Calibration: Three Case Studies in Molecular Ecology

Time-scales estimated from sequence data play an important role in molecular ecology. They can be used to draw correlations between evolutionary and palaeoclimatic events, to measure the tempo of speciation, and to study the demographic history of an endangered species. In all of these studies, it is paramount to have accurate estimates of time-scales and substitution rates. Molecular ecological studies typically focus on intraspecific data that have evolved on genealogical scales, but often these studies inappropriately employ deep fossil calibrations or canonical substitution rates (e.g., 1% per million years for birds and mammals) for calibrating estimates of divergence times. These approaches can yield misleading estimates of molecular time-scales, with significant impacts on subsequent evolutionary and ecological inferences. We illustrate this calibration problem using three case studies: avian speciation in the late Pleistocene, the demographic history of bowhead whales, and the Pleistocene biogeography of brown bears. For each data set, we compare the date estimates that are obtained using internal and external calibration points. In all three cases, the conclusions are significantly altered by the application of revised, internally-calibrated substitution rates. Collectively, the results emphasise the importance of judicious selection of calibrations for analyses of recent evolutionary events.
In vitro fertilization and acupuncture: clinical efficacy and mechanistic basis.

OBJECTIVE To provide an overview of the use of acupuncture as an adjunct therapy for in vitro fertilization (IVF), including an evidence-based evaluation of its efficacy and safety and an examination of possible mechanisms of action. DESIGN Literature review using PubMed, the Science Citation Index, The Cochrane Library (Database of Systematic Reviews and Central Register of Controlled Trials), the New England School of Acupuncture library databases, and a cross-referencing of published data, personal libraries, and Chinese medicine textbooks. RESULTS Limited but supportive evidence from clinical trials and case series suggests that acupuncture may improve the success rate of IVF and the quality of life of patients undergoing IVF and that it is a safe adjunct therapy. However, this conclusion should be interpreted with caution because most studies reviewed had design limitations, and the acupuncture interventions employed often were not consistent with traditional Chinese medical principles. The reviewed literature suggests 4 possible mechanisms by which acupuncture could improve the outcome of IVF: modulating neuroendocrinological factors; increasing blood flow to the uterus and ovaries; modulating cytokines; and reducing stress, anxiety, and depression. CONCLUSIONS More high-quality randomized, controlled trials incorporating placebo acupuncture controls, authentic acupuncture interventions, and a range of outcome measures representative of both clinical outcomes and putative mechanistic processes are required to better assess the efficacy of acupuncture as an adjunct for IVF.
Acute respiratory failure in severe hematologic disorders

The development of acute respiratory failure (ARF) in patients with hematologic disorders (HDs) is a life-threatening condition which does not respond well to intensive therapy. We present our experience in the use of intensive therapy for a group of 30 patients suffering from leukemia (21 cases), bone-marrow aplasia (6 cases), or lymphoma (3 cases). Seven had undergone bone-marrow transplantation. All 30 patients were hypoxemic and responded poorly to the administration of high oxygen concentrations via face mask. All were admitted to our intensive respiratory unit (IRU), where 26 received oxygen via mechanical ventilation, and 4 received continuous positive airway pressure (CPAP). Definitive diagnosis was established in 19 (63%) patients. A premortem diagnosis obtained in 8 (26%) cases did not change therapy. The diagnostic accuracy of serology and transbronchial biopsy was low. Of the 6 (20%) patients who recovered from ARF, only 2 were discharged from the hospital. The remaining 24 (80%) patients died in the IRU.
An updated systematic review and meta‐analysis on the association between Helicobacter pylori infection and iron deficiency anemia

We conducted an updated systematic review and meta‐analysis to examine the prevalence of depleted iron stores among persons infected with Helicobacter pylori compared to uninfected ones. We also assessed the impact of anti‐H. pylori eradication therapy plus iron therapy on ferritin and hemoglobin levels compared to iron therapy alone.
Quantum Non-Markovian Piecewise Dynamics from Collision Models

Recently, a large class of quantum non-Markovian piecewise dynamics for an open quantum system obeying closed evolution equations has been introduced [1]. These dynamics have been defined in terms of a waiting-time distribution between quantum jumps, along with quantum maps describing the effect of jumps and the system evolution between them. Here, we present a quantum collision model with memory, whose reduced dynamics in the continuous-time limit reproduces the above class of non-Markovian piecewise dynamics, thus providing an explicit microscopic realization.
Rapid impact of effective treatment on transmission of multidrug-resistant tuberculosis.

BACKGROUND Effective treatment for drug-susceptible tuberculosis (TB) rapidly renders patients non-infectious, long before conversion of sputum acid-fast smear or culture to negative. Multidrug-resistant TB (MDR-TB) patients on treatment are currently assumed to remain infectious for months. While the resources required for prolonged hospitalization are a barrier to the scale-up of MDR-TB treatment, the safety of community treatment is clear. OBJECTIVES To estimate the impact of treatment on infectiousness among MDR-TB patients. METHODS A series of five human-to-guinea pig TB transmission studies was conducted to test various interventions for infection control. Guinea pigs in adjacent chambers were exposed to exhaust air from a hospital ward occupied by mostly sputum smear- and culture-positive MDR-TB patients. The guinea pigs then underwent tuberculin skin testing for infection. Only the control groups of guinea pigs from each study (no interventions used) provide the data for this analysis. The number of guinea pigs infected in each study is reported and correlated with Mycobacterium tuberculosis drug susceptibility relative to treatment. RESULTS Despite exposure to presumably infectious MDR-TB patients, infection percentages among guinea pigs ranged from 1% to 77% in the five experiments conducted. In one experiment in which guinea pigs were exposed to 27 MDR-TB patients newly started on effective treatment for 3 months, there was minimal transmission. In four other experiments with greater transmission, guinea pigs had been exposed to patients with unsuspected extensively drug-resistant tuberculosis who were not on effective treatment. CONCLUSIONS In this model, effective treatment appears to render MDR-TB patients rapidly non-infectious. Further prospective studies on this subject are needed.
Am80‐GCSF synergizes myeloid expansion and differentiation to generate functional neutrophils that reduce neutropenia‐associated infection and mortality

Neutrophils generated by granulocyte colony‐stimulating factor (GCSF) are functionally immature and, consequently, cannot effectively reduce infection and infection‐related mortality in cancer chemotherapy‐induced neutropenia (CCIN). Am80, a retinoic acid (RA) agonist that enhances granulocytic differentiation by selectively activating transcription factor RA receptor alpha (RARα), alternatively promotes RA‐target gene expression. We found that in normal and malignant primary human hematopoietic specimens, Am80‐GCSF combination coordinated proliferation with differentiation to develop complement receptor‐3 (CR3)‐dependent neutrophil innate immunity, through altering transcription of RA‐target genes RARβ2, C/EBPε, CD66, CD11b, and CD18. This led to generation of functional neutrophils capable of fighting infection, whereas neutralizing neutrophil innate immunity with anti‐CD18 antibody abolished neutrophil bactericidal activities induced by Am80‐GCSF. Further, Am80‐GCSF synergy was evaluated using six different dose‐schedule‐infection mouse CCIN models. The data demonstrated that during “emergency” granulopoiesis in CCIN mice undergoing transient systemic intravenous bacterial infection, Am80 effect on differentiating granulocytic precursors synergized with GCSF‐dependent myeloid expansion, resulting in large amounts of functional neutrophils that reduced infection. Importantly, extensive survival tests covering a full cycle of mouse CCIN with perpetual systemic intravenous bacterial infection proved that without causing myeloid overexpansion, Am80‐GCSF generated sufficient numbers of functional neutrophils that significantly reduced infection‐related mortality in CCIN mice. These findings reveal a differential mechanism for generating functional neutrophils to reduce CCIN‐associated infection and mortality, providing a rationale for future therapeutic approaches.
The regeneration of stellar bars by tidal interactions: numerical simulations of fly-by encounters

We study the regeneration of stellar bars triggered by a tidal interaction, using numerical simulations of either purely stellar or stellar+gas disc galaxies. We find that interactions which are sufficiently strong to regenerate the bar in the purely stellar models do not lead to a regeneration in the dissipative models, owing to the induced gas inflow in those models. In models in which the bar can be regenerated, we find a tight correlation between the strength and the pattern speed of the induced bar. This relation can be explained by a significant radial redistribution of angular momentum in the disc due to the interaction, similar to the processes and correlations found for isolated barred spirals. Furthermore, we show that the regenerated bars show the same dynamical properties as their isolated counterparts.
Tree-Ring Reconstruction of Debris-Flow Events Leading to Overbank Sedimentation on the Illgraben Cone (Valais Alps, Switzerland)

Dendrogeomorphological analyses of trees affected by debris flows have regularly been used to date past events. However, while previous studies in the Swiss Alps have focused primarily on granitic and gneissic debris-flow material and on Larix decidua Mill. and Picea abies (L.) Karst. trees, they have - at the same time - widely disregarded torrents dominated by finely fractured calcareous and dolomitic lithologies and forests populated with Pinus sylvestris L. In this paper, we report on results obtained from a debris-flow cone in the Rhone valley (Valais, Switzerland) where very fine and muddy material (limestone, dolomite, quartzite and calcite) occasionally affects P. sylvestris trees. Based on the results of a geomorphic map, 1004 increment cores from 451 disturbed P. sylvestris, 37 L. decidua and five P. abies trees were sampled, allowing reconstruction of 15 events between AD 1793 and 2005 as well as the determination of breakout locations of events. From the data, it also appears that debris-flow material only rarely left the incised channel over the last 200 years and that overbank sedimentation events did not occur after 1961, when a rockslide delivered large amounts of erodible material and subsequent debris flows caused an important incision of the canyon on the cone.
The expression of compassionate love in everyday compassionate acts

Compassionate love (CL) is a form of altruistic, caring love that emphasizes concern for the other’s well-being. How is CL expressed in marriage? To address this question, we adopted a behavioral acts perspective in which we examined among newlyweds the presence or absence of a series of behavioral manifestations of CL. A sample of 175 newlywed couples completed daily diaries for 2 weeks, describing their own compassionate acts and their perceptions of their partners’ compassionate acts. We found clear evidence that CL acts contributed to both spouses’ daily marital satisfaction. These effects were independent of general positivity or negativity of behavior. We also employed a quasi-signal detection analysis to determine whether acts that both partners recognize as compassionate are more influential than acts that only one of them acknowledges. This hypothesis was supported. Our findings indicate that CL-related behavior represents a beneficial form of caring interaction that merits further attention in relationship research.
The Macrophage Colony-Stimulating Factor 1 Response Signature in Breast Carcinoma

Purpose: Macrophages play an important role in breast carcinogenesis. The pathways that mediate the macrophage contribution to breast cancer and the heterogeneity that exists within macrophages are incompletely understood. Macrophage colony-stimulating factor 1 (CSF1) is the primary regulator of tissue macrophages. The purpose of this study was to define a novel CSF1 response signature and to evaluate its clinical and biological significance in breast cancer. Experimental Design: We defined the CSF1 response signature by identifying genes overexpressed in tenosynovial giant cell tumor and pigmented villonodular synovitis (tumors composed predominantly of macrophages recruited in response to the overexpression of CSF1) compared with desmoid-type fibromatosis and solitary fibrous tumor. To characterize the CSF1 response signature in breast cancer, we analyzed the expression of CSF1 response signature genes in eight published breast cancer gene expression data sets (n = 982) and did immunohistochemistry and in situ hybridization for CSF1 response genes on a breast cancer tissue microarray (n = 283). Results: In both the gene microarray and tissue microarray analyses, a consistent subset (17-25%) of breast cancers shows the CSF1 response signature. The signature is associated with higher tumor grade, decreased expression of estrogen receptor, decreased expression of progesterone receptor, and increased TP53 mutations (P < 0.001). Conclusions: Our data show that the CSF1 response signature is consistently seen in a subset of breast carcinomas and correlates with biological features of the tumor. Our findings provide insight into macrophage biology and may facilitate the development of personalized therapy for patients most likely to benefit from CSF1-targeted treatments.
Survey of patient opinion on tobacco cessation counseling and services in a dental teaching institution and hospital.

PURPOSE The objective of this study was to assess the opinion of dental patients who use tobacco towards receiving tobacco cessation counseling and services in a dental college and hospital setting. MATERIALS AND METHODS A cross-sectional descriptive survey method using a structured questionnaire was used in this study. Participants were patients attending The Oxford Dental College, Hospital, and Research Center, Bengaluru, India. Each patient in the clinic waiting room was asked by the investigator to complete a 29-item self-administered questionnaire. Descriptive statistics and bivariate analysis using Fisher's exact tests were used for statistical analysis of the data. RESULTS Ninety-six percent (n = 770) of tobacco users had previously attempted to quit tobacco and 95.7% were willing to quit. Sixteen percent (n = 132) of respondents reported that they currently used tobacco. About 83% of tobacco users agreed that the student dentist should ask patients whether or not they use tobacco, 79.4% agreed that the student dentist should advise tobacco users to quit, and 81.4% agreed that student dentists should offer information on quitting tobacco to patients who want to quit. Only 12.5% (n = 100) of the patients who use tobacco were aware of the community resources available to quit tobacco. CONCLUSION This study shows that patients expect and felt comfortable with receiving tobacco cessation counseling services by oral health professionals in a dental hospital setting.
ON THE RADIATIVE EFFICIENCIES, EDDINGTON RATIOS, AND DUTY CYCLES OF LUMINOUS HIGH-REDSHIFT QUASARS

We investigate the characteristic radiative efficiency ϵ, Eddington ratio λ, and duty cycle P0 of high-redshift active galactic nuclei (AGNs), drawing on measurements of the AGN luminosity function at z = 3–6 and, especially, on recent measurements of quasar clustering at z = 3–4.5 from the Sloan Digital Sky Survey. The free parameters of our models are ϵ, λ, and the normalization, scatter, and redshift evolution of the relation between black hole (BH) mass MBH and halo virial velocity Vvir. We compute the luminosity function from the implied growth of the BH mass function and the quasar correlation length from the bias of the host halos. We test our adopted formulae for the halo mass function and halo bias against measurements from the large N-body simulation developed by the MICE collaboration. The strong clustering of AGNs observed at z = 3 and, especially, at z = 4 implies that massive BHs reside in rare, massive dark matter halos. Reproducing the observed luminosity function then requires high efficiency ϵ and/or low Eddington ratio λ, with a lower limit (based on 2σ agreement with the measured z = 4 correlation length) ϵ ≳ 0. 7λ/(1 + 0.7λ), implying ϵ ≳ 0.17 for λ>0.25. Successful models predict high duty cycles, P0 ∼ 0.2, 0.5, and 0.9 at z = 3.1, 4.5, and 6, respectively, and they require that the fraction of halo baryons locked in the central BH is much larger than the locally observed value. The rapid drop in the abundance of the massive and rare host halos at z > 7 implies a proportionally rapid decline in the number density of luminous quasars, much stronger than simple extrapolations of the z = 3–6 luminosity function would predict. For example, our most successful model predicts that the highest redshift quasar in the sky with true bolometric luminosity L > 1047.5 erg s−1 should be at z ∼ 7.5, and that all quasars with higher apparent luminosities would have to be magnified by lensing.
Antagonistic and Detoxification Potentials of Trichoderma Isolates for Control of Zearalenone (ZEN) Producing Fusarium graminearum

Fungi belonging to Fusarium genus can infect crops in the field and cause subsequent mycotoxin contamination, which leads to yield and quality losses of agricultural commodities. The mycotoxin zearalenone (ZEN) produced by several Fusarium species (such as F. graminearum and F. culmorum) is a commonly-detected contaminant in foodstuffs, posing a tremendous risk to food safety. Thus, different strategies have been studied to manage toxigenic pathogens and mycotoxin contamination. In recent years, biological control of toxigenic fungi is emerging as an environment-friendly strategy, while Trichoderma is a fungal genus with great antagonistic potentials for controlling mycotoxin producing pathogens. The primary objective of this study was to explore the potentials of selected Trichoderma isolates on ZEN-producing F. graminearum, and the second aim was to investigate the metabolic activity of different Trichoderma isolates on ZEN. Three tested Trichoderma isolates were proved to be potential candidates for control of ZEN producers. In addition, we reported the capacity of Trichoderma to convert ZEN into its reduced and sulfated forms for the first time, and provided evidences that the tested Trichoderma could not detoxify ZEN via glycosylation. This provides more insight in the interaction between ZEN-producing fungi and Trichoderma isolates.
Vonoprazan 20 mg vs lansoprazole 30 mg for endoscopic submucosal dissection-induced gastric ulcers

AIM To compare the healing effects of vonoprazan and lansoprazole on gastric ulcers induced by endoscopic submucosal dissection (ESD). METHODS Data were obtained from a total of 26 patients. Fourteen patients were randomized to the vonoprazan group and 12 were randomized to the lansoprazole group. Patients were administered either 20 mg vonoprazan or 30 mg lansoprazole per day after ESD. Endoscopic images just after ESD, on day 8, and on day 28 were used for the evaluation of the shrinking rate of ESD ulcers. The shrinking rates and the incidence of delayed bleeding were compared between the 2 groups. RESULTS The shrinking rates of ESD ulcers on day 8 [vonoprazan group: 61.8% (range: 24.0%-91.1%), lansoprazole group: 71.3% (range: 25.2%-88.6%)] and on day 28 [vonoprazan group: 95.3% (range: 76.2%-100%), lansoprazole group: 97.2% (range: 81.1%-99.8%)] were not statistically different between the 2 groups. On day 28, most of the ulcers in both groups healed to more than 90%, whereas 3 of 14 (21.4%) in the vonoprazan group and 1 of 12 (8.3%) in the lansoprazole group had delayed ulcer healing, which was not statistically different (P = 0.356). The frequency of delayed bleeding was 0 in the both groups. Taken together, there were no significant differences between the two drug groups. CONCLUSION Our study indicates that vonoprazan is potent for the management of ESD ulcers although lansoprazole is also sufficient and cost-effective.
Alloantigen‐specific de novo‐induced Foxp3+ Treg revert in vivo and do not protect from experimental GVHD

Induced antigen‐specific Foxp3+ T cells (iTreg) are being discussed as a promising alternative to polyclonal natural Foxp3+ T cells (nTreg) for cell‐based therapies, particularly to achieve transplantation tolerance. Using Foxp3eGFP‐reporter mice, we here establish an efficient protocol to induce and expand alloantigen‐specific iTreg from Foxp3−CD4+ T cells with cluster‐disrupted DC. These iTreg were mainly CD62L+ and showed efficient suppressive activity in vitro. However, in contrast to nTreg, adoptively transferred iTreg entirely failed to prevent lethal graft versus host disease (GVHD). Within irradiated recipients, the majority of adoptively transferred Foxp3+ iTreg, but not Foxp3+ nTreg quickly reverted to Foxp3−CD4+ T cells. We therefore suggest that therapeutic approaches to treat GVHD should rely on nTreg, whereas the use of de novo alloantigen‐induced iTreg should be handled with caution since the stability of the regulatory phenotype of the iTreg could be of major concern.