Miracle-dz/UniFAR-FTUs huggingface dataset:
Key Concepts in Leisure Studies

Introduction Adding Leisure Values Articulation Authenticity Bodies Cultural Capital Disciplinary Apparatuses Disneyfication Ecstasy Education as Leisure Effects Analysis Escape Ethnography Fantasy Figurationalism Food Functionalism Gazes Gender Gramscianism Heritage Hyperreality Identities Ideology Illegal Leisure Leisure Policy McDonaldization Narratives Pleasures Pornography Postmodernism Posts Race and Leisure Semiotics Shopping Social Class Virtual Leisure Visitor Interpretation Work-Leisure Relationships Youth Subcultures
Identification of Phosphomethylethanolamine N-Methyltransferase from Arabidopsis and Its Role in Choline and Phospholipid Metabolism*

Three sequential methylations of phosphoethanolamine (PEA) are required for the synthesis of phosphocholine (PCho) in plants. A cDNA encoding an N-methyltransferase that catalyzes the last two methylation steps was cloned from Arabidopsis by heterologous complementation of a Saccharomyces cerevisiae cho2, opi3 mutant. The cDNA encodes phosphomethylethanolamine N-methyltransferase (PMEAMT), a polypeptide of 475 amino acids that is organized as two tandem methyltransferase domains. PMEAMT shows 87% amino acid identity to a related enzyme, phosphoethanolamine N-methyltransferase, an enzyme in plants that catalyzes all three methylations of PEA to PCho. PMEAMT cannot use PEA as a substrate, but assays using phosphomethylethanolamine as a substrate result in both phosphodimethylethanolamine and PCho as products. PMEAMT is inhibited by the reaction products PCho and S-adenosyl-l-homocysteine, a property reported for phosphoethanolamine N-methyltransferase from various plants. An Arabidopsis mutant with a T-DNA insertion associated with locus At1g48600 showed no transcripts encoding PMEAMT. Shotgun lipidomic analyses of leaves of atpmeamt and wild-type plants generated phospholipid profiles showing the content of phosphatidylmethylethanolamine to be altered relative to wild type with the content of a 34:3 lipid molecular species 2-fold higher in mutant plants. In S. cerevisiae, an increase in PtdMEA in membranes is associated with reduced viability. This raises a question regarding the role of PMEAMT in plants and whether it serves to prevent the accumulation of PtdMEA to potentially deleterious levels.
Ventilatory stability to transient CO2 disturbances in hyperoxia and normoxia in awake humans.

Modarreszadeh and Bruce (J. Appl. Physiol. 76: 2765-2775, 1994) proposed that continuous random disturbances in arterial PCO2 are more likely to elicit ventilatory oscillation patterns that mimic periodic breathing in normoxia than in hyperoxia. To test this hypothesis experimentally, in nine awake humans we applied pseudorandom binary inspired CO2 fraction stimulation in normoxia and hyperoxia to derive the closed-loop and open-loop ventilatory responses to a brief CO2 disturbance in terms of impulse responses and transfer functions. The closed-loop impulse response has a significantly higher peak value [0.143 +/- 0.071 vs. 0.079 +/- 0.034 (SD) l . min-1 . 0.01 l CO2-1, P = 0.014] and a significantly shorter 50% response duration (42.7 +/- 13.3 vs. 72.3 +/- 27.6 s, P = 0.020) in normoxia than in hyperoxia. Therefore, the ventilatory responses to transient CO2 disturbances are less damped (but generally not oscillatory) in normoxia than in hyperoxia. For the closed-loop transfer function, the gain in normoxia increased significantly (P < 0.0005), while phase delay decreased significantly (P < 0.0005). The gain increased by 108.5, 186.0, and 240.6%, while phase delay decreased by 26.0, 18.1, and 17.3%, at 0. 01, 0.03, and 0.05 Hz, respectively. Changes in the same direction were found for the open-loop system. Generally, an oscillatory ventilatory response to a small transient CO2 disturbance is unlikely during wakefulness. However, changes in parameters that lead to additional increases in chemoreflex loop gain are more likely to initiate oscillations in normoxia than in hyperoxia.
Thrombus formation during intracranial aneurysm coil placement: treatment with intra-arterial abciximab.

BACKGROUND AND PURPOSE The management of thrombus formation during coil placement in an intracranial aneurysm is important in minimizing periprocedural morbidity and mortality. We report on seven cases in which the primary treatment for thrombus formation during such coil placement was intra-arterial abciximab infusion. METHODS Clinical and radiologic records of 100 consecutive patients who underwent coil placement in intracranial aneurysms at our institution during a 1-year period were reviewed. We identified seven cases (four ruptured aneurysms, three unruptured aneurysms) in which thrombus formation occurred during the procedure. RESULTS Intra-arterial abciximab infusion, up to 5 mg, completely dissolved the thrombus in four of seven patients and almost completely dissolved it in two. In one patient with distal emboli, recanalization was not achieved. In two patients, an intravenous bolus of abciximab without 12-hour infusion was also given adjunctively. In one patient, leakage of contrast material occurred; this was related to the intra-arterial infusion. Clinically, no new neurologic deficits were directly related to the intra-arterial abciximab infusion. Six patients had good clinical outcome, and one patient died. CONCLUSION Relatively low-dose, intra-arterial abciximab infusion can immediately dissolve an acute thrombus that forms during intracranial aneurysm coil placement. Although neither the optimal dose of intra-arterial abciximab nor the need to supplement the intra-arterial infusion with intravenous administration was established, we preliminarily found that low-dose intra-arterial abciximab infusion may be relatively effective and safe in this setting, even in patients with acute subarachnoid hemorrhage.
Two Approximate Voting Schemes for Reliable Computing

This paper relies on the principles of inexact computing to alleviate the issues arising in static masking by voting for reliable computing in the nanoscales. Two schemes that utilize in different manners approximate voting, are proposed. The first scheme is referred to as inexact double modular redundancy (IDMR). IDMR does not resort to triplication, thus saving overhead due to modular replication. This scheme is crudely adaptive in its operation, i.e., it allows a threshold to determine the validity of the module outputs. IDMR operates by initially establishing the difference between the values of the outputs of the two modules; only if the difference is below a preset threshold, then the voter calculates the average value of the two module outputs. The second scheme (ITDMR) combines IDMR with TMR (triple modular redundancy) by using novel conditions in the comparison of the outputs of the three modules. Within an inexact framework, the majority is established using different criteria; in ITDMR, adaptive operation is carried further than IDMR to include approximate voting in a pairwise fashion. So, the validity of the three inputs is established and when only two of the three inputs satisfy the threshold condition, the IDMR operation is utilized. An extensive analysis that includes the voting circuits as well as a probabilistic framework is included. The proposed IDMR and ITDMR schemes improve the power dissipation and tolerance to variations compared to a traditional TMR. To further validate the applicability of the proposed schemes, inexact voting has been used in two applications (image processing and FIR filtering); the simulation results show that performance is substantially improved over TMR.
Cancer pain management among underserved minority outpatients

Minority patients with cancer are at risk for undertreatment of cancer‐related pain. Most studies of patient‐related barriers to pain control have surveyed primarily non‐Hispanic Caucasian patients. The purpose of the current study was to explore barriers to optimal pain management among African‐American and Hispanic patients with cancer through the use of structured patient interviews. Structured interviews allowed the authors to probe for previously unidentified barriers to pain management in these populations.
Family carers’ experience of caring for an older parent with severe and persistent mental illness

While the burden of caring for older people with chronic medical illness and dementia has been well documented, considerably less is known about how carers develop the strength and resilience to sustain this important role with older family members with mental illness. The aim of the study was to understand the lived experience of primary caregivers of older people with severe and persistent mental illness, and to explore what, if anything, helps to sustain them in their caring role. An interpretative phenomenological analysis approach was adopted, and qualitative interviews were used with 30 primary caregivers. Two overarching themes, and related subthemes, were abstracted from the data. First, caring is a difficult and demanding responsibility. It affects carers adversely, emotionally, physically, socially, and financially, and their lifestyle in general. This is reflected in three subthemes: (i) physically and emotionally draining; (ii) grieving about the loss; (iii) and adverse effects on lifestyle and social relationships. Second, carers develop resilience in caring, which helps sustain them in their role, as illustrated in three subthemes: (i) caring as purposeful and satisfying; (ii) harnessing social support from others; and (iii) purposefully maintaining their own well-being. Community mental health nurses have a key role in assessing carers’ needs and supporting them in their caring role.
Dynamic Topic Adaptation for SMT using Distributional Profiles

Despite its potential to improve lexical selection, most state-of-the-art machine translation systems take only minimal contextual information into account. We capture context with a topic model over distributional profiles built from the context words of each translation unit. Topic distributions are inferred for each translation unit and used to adapt the translation model dynamically to a given test context by measuring their similarity. We show that combining information from both local and global test contexts helps to improve lexical selection and outperforms a baseline system by up to 1.15 BLEU. We test our topic-adapted model on a diverse data set containing documents from three different domains and achieve competitive performance in comparison with two supervised domain-adapted systems.
Why parents of children with neurodevelopmental disabilities requiring gastrostomy feeding need more support

This was a qualitative research study of parental perceptions of gastrostomy feeding before surgery using an in‐depth interview in the parental home to examine the factors parents consider when gastrostomy feeding is recommended and to identify the need for support. Participants were a subgroup of families taking part in a larger research study evaluating gastrostomy placement in children with severe neurodevelopmental disabilities at a major paediatric centre in the UK between 1998 and 2000. Parents of 22 children (13 males, nine females; mean age 4 years 8 months [SD 3 years 6 months]; age range 1 year 1 month to 13 years 3 months) were interviewed. Categories of disability were: cerebral palsy (n=10), a syndrome of chromosomal or genetic origin (n=10), and unconfirmed diagnoses (n=2). Thirteen children were recommended for a gastrostomy and seven were recommended for a gastrostomy with an antireflux procedure. Four families were undecided about surgery at the time of the interview, two of whom went ahead with the procedure some time later. Parental accounts of oral and tube feeding were both contradictory and ambivalent. Concerns about the loss of oral feeding, which was regarded as having a range of psychosocial effects for the child and family, were raised. Both oral and tube feeding have multiple meanings for parents and signify more than obtaining an adequate nutritional intake. The need for additional information about the risks and benefits of gastrostomy and how tube feeding fits into the context of everyday life were dominant themes. The biomedical emphasis on health and weight‐gains may fail to reflect parental concerns about tube and oral feeding. There is a need for greater practical and emotional support for families feeding children with severe disabilities.
Memory-based control with recurrent neural networks

Partially observed control problems are a challenging aspect of reinforcement learning. We extend two related, model-free algorithms for continuous control -- deterministic policy gradient and stochastic value gradient -- to solve partially observed domains using recurrent neural networks trained with backpropagation through time. We demonstrate that this approach, coupled with long-short term memory is able to solve a variety of physical control problems exhibiting an assortment of memory requirements. These include the short-term integration of information from noisy sensors and the identification of system parameters, as well as long-term memory problems that require preserving information over many time steps. We also demonstrate success on a combined exploration and memory problem in the form of a simplified version of the well-known Morris water maze task. Finally, we show that our approach can deal with high-dimensional observations by learning directly from pixels. We find that recurrent deterministic and stochastic policies are able to learn similarly good solutions to these tasks, including the water maze where the agent must learn effective search strategies.
Toll-Like Receptors in Esophageal Cancer

Esophageal squamous cell carcinoma and esophageal adenocarcinoma are cancers of high mortality. EAC develops through Barrett’s esophagus (BE) and columnar dysplasia, preceded by gastro-esophageal reflux disease. The risk of esophageal squamous cell carcinoma is increased by smoking and alcohol consumption. New treatment options for esophageal cancer are desperately needed. Toll-like receptors (TLRs) play a central role in mammalian immunity and cancer. TLRs are activated by microbial components, such as lipopolysaccharide, flagellin, DNA, and RNA, as well as endogenous ligands, including heat-shock proteins and endogenous DNA. This review summarizes the studies on TLRs in esophageal squamous cell carcinoma and EAC. It has been shown that TLRs 1–10 are expressed in the normal esophagus. In esophageal squamous cell carcinoma, TLRs3, 4, 7, and 9 have been studied, showing associations to aggressive disease properties. In BE and EAC, only TLRs4, 5, and 9 have been studied. In the review, we discuss the implications of TLRs in esophageal cancer.
Disability and physical activity behaviours : an application of theoretical frameworks

Background: The prevalence of disability increases with age; therefore with an aging population, interventions to reduce disability are crucial. This thesis adopts a behavioural conceptualisation of disability. The theoretical frameworks of the International Classification of Functioning, Disability and Health (ICF), the Theory of Planned Behaviour (TPB) and the integrated ICF/TPB model are applied to investigate disability and physical activity (PA) behaviours. The thesis aims to: (1) identify the factors involved in the prioritisation of patients for total joint replacement; (2) classify patient pre-operative expectations of total hip replacement (THR) and investigate the relationship between expectations and recovery after surgery, and; (3) test whether the TPB and theory-based interventions can predict and explain PA within individuals. Method: Five studies were conducted. In the first study, health professionals judged whether the items from two prioritisation tools measured each of the ICF constructs. In the second study, surgeons ranked patient vignettes, which differed by constructs from the integrated model, in order of priority for THR. In the third study, a large cohort of THR patients reported expectations of surgery pre-operatively. Health and functioning were also reported pre-operatively and 1-year post-operatively. The fourth and fifth studies were a series of experimental n-of-1 studies using diary methods assessing TPB cognitions and PA behaviours. Results: There is a lack of agreement between judges in relation to the content of many of the items from prioritisation tools. Behavioural and psychological factors can influence prioritisation for THR. The majority of patient expectations of THR addressed activities and social participation; however, the evidence for a relationship between expectations and recovery was limited. The TPB can predict PA within some individuals but the evidence in support of interventions to increase PA was limited. Discussion: The findings provide important clinical and theoretical implications for understanding disability and physical activity behaviours.
Growth stimulation leads to cellular senescence when the cell cycle is blocked

We tested a hypothesis that activation of growth-promoting pathways is required for cellular senescence. In the presence of serum, induction of p21 caused senescence, characterized by beta-Galactosidase staining, cell hypertrophy, increased levels of cyclin D1 and active TOR (target of rapamycin, also known as mTOR). Serum starvation and rapamycin inhibited TOR and prevented the expression of some senescent markers, despite high levels of p21 and cell cycle arrest. In the presence of serum, p21-arrested cells irreversibly lost proliferative potential. In contrast, when cells were arrested by p21 in the absence of serum, they retained the capacity to resume proliferation upon termination of p21 induction. In normal human cells such as WI38 fibroblasts and retinal pigment epithelial (RPE) cells, serum starvation caused quiescence, which was associated with low levels of cyclin D1, inactive TOR and slim-cell morphology. In contrast, cellular senescence with high levels of TOR activity was induced by doxorubicin (DOX), a DNA damaging agent, in the presence of serum. Inhibition of TOR partially prevented senescent phenotype caused by DOX. Thus growth stimulation coupled with cell cycle arrest leads to senescence, whereas quiescence (a condition with inactive TOR) prevents senescence.
Region‐specific epithelial cell dynamics during branching morphogenesis

Background: Epithelial cells of developing embryonic organs, such as salivary glands, can display substantial motility during branching morphogenesis. Their dynamic movements and molecules involved in their migration are not fully characterized. Results: We generated transgenic mice expressing photo‐convertible KikGR and tracked the movements of individual cells highlighted by red fluorescence in different regions of developing salivary glands. Motility was highest for outer bud epithelial cells adjacent to the basement membrane, lower in inner bud cells, and lowest in duct cells. The highly motile outer cells contacting the basement membrane were pleomorphic, whereas inner cells were rounded. Peripheral cell motility was disrupted by antibodies inhibiting α6+β1 integrins and the nonmuscle myosin II inhibitor blebbistatin. Inner bud cell migration was unaffected by these inhibitors, but their rate of migration was stimulated by inhibiting E‐cadherin. Conclusions: Cell motility in developing salivary glands was highest in cells in contact with the basement membrane. The basement membrane‐associated motility of these outer bud cells depended on integrins and myosin II, but not E‐cadherin. In contrast, motility of inner bud cells was restrained by E‐cadherin. These findings identify the importance of integrin‐dependent basement membrane association for the morphology, tissue organization, and lateral motility of morphogenetic epithelial cells. Developmental Dynamics 242:1066–1077, 2013. © 2013 Wiley Periodicals, Inc.
Role of Ubiquitylation in Controlling Suppressor of Cytokine Signalling 3 (SOCS3) Function and Expression

The realisation that unregulated activation of the Janus kinase–signal transducer and activator of transcription (JAK–STAT) pathway is a key driver of a wide range of diseases has identified its components as targets for therapeutic intervention by small molecule inhibitors and biologicals. In this review, we discuss JAK-STAT signalling pathway inhibition by the inducible inhibitor “suppressor of cytokine signaling 3 (SOCS3), its role in diseases such as myeloproliferative disorders, and its function as part of a multi-subunit E3 ubiquitin ligase complex. In addition, we highlight potential applications of these insights into SOCS3-based therapeutic strategies for management of conditions such as vascular re-stenosis associated with acute vascular injury, where there is strong evidence that multiple processes involved in disease progression could be attenuated by localized potentiation of SOCS3 expression levels.
Is water H[2]O? : evidence, realism and pluralism

Introduction. - Water and the Chemical Revolution. - Piles of Confusion: the Mixed Blessing of Electrolysis. - HO or H2O? -Evidence in Action (or, The Contextuality of Evidence). - Pluralism in Practice. - Realism in a Free Society. - Epilogue: Complementary Science Continued.
Eurographics Symposium on Geometry Processing 2015 Partial Functional Correspondence

Figure 1: Partial functional correspondence between two pairs of shapes with large missing parts. For each pair we show the matrix C representing the functional map in the spectral domain, and the action of the map by transferring colors from one shape to the other. The special slanted-diagonal structure of C induced by the partiality transformation is first estimated from spectral properties of the two shapes, and then exploited to drive the matching process. Abstract In this paper, we propose a method for computing partial functional correspondence between non-rigid shapes. We use perturbation analysis to show how removal of shape parts changes the Laplace-Beltrami eigenfunctions, and exploit it as a prior on the spectral representation of the correspondence. Corresponding parts are optimization variables in our problem and are used to weight the functional correspondence; we are looking for the largest and most regular (in the Mumford-Shah sense) parts that minimize correspondence distortion. We show that our approach can cope with very challenging correspondence settings.
Spam filter evaluation with imprecise ground truth

When trained and evaluated on accurately labeled datasets, online email spam filters are remarkably effective, achieving error rates an order of magnitude better than classifiers in similar applications. But labels acquired from user feedback or third-party adjudication exhibit higher error rates than the best filters -- even filters trained using the same source of labels. It is appropriate to use naturally occuring labels -- including errors -- as training data in evaluating spam filters. Erroneous labels are problematic, however, when used as ground truth to measure filter effectiveness. Any measurement of the filter's error rate will be augmented and perhaps masked by the label error rate. Using two natural sources of labels, we demonstrate automatic and semi-automatic methods that reduce the influence of labeling errors on evaluation, yielding substantially more precise measurements of true filter error rates.
Ascorbic acid responsive genes during neuronal differentiation of embryonic stem cells

Ascorbic acid has been reported to enhance differentiation of embryonic stem (ES) cells into neurons, however, the specific functions of ascorbic acid have not been defined yet. To address this issue, gene expression profiling was performed using cDNA microarray. Ascorbic acid increased the expressions of genes involved in neurogenesis, maturation, and neurotransmission. Furthermore, statistical analysis using Fisher's exact test revealed ascorbic acid significantly modulated the genes involved in cell adhesion and development category. These results provide information on the role for ascorbic acid during neuronal differentiation of ES cells and might contribute to large-scale generation of neurons for future clinical treatment.