Miracle-dz/UniFAR-FTUs huggingface dataset:
A Volumetric/Iconic Frequency Domain Representation for Objects With Application for Pose Invariant Face Recognition

A novel method for representing 3D objects that unifies viewer and model centered object representations is presented. A unified 3D frequency-domain representation, called volumetric frequency representation (VFR), encapsulates both the spatial structure of the object and a continuum of its views in the same data structure. The frequency-domain image of an object viewed from any direction can be directly extracted employing an extension of the projection slice theorem, where each Fourier-transformed view is a planar slice of the volumetric frequency representation. The VFR is employed for pose-invariant recognition of complex objects, such as faces. The recognition and pose estimation is based on an efficient matching algorithm in a four-dimensional Fourier space. Experimental examples of pose estimation and recognition of faces in various poses are also presented.
Significance of TP53, CDKN2A, SMAD4 and KRAS in Pancreatic Cancer

The present review demonstrates the major tumor suppressor genes, including TP53, CDKN2A and SMAD4, associated with pancreatic cancer. Each gene’s role, prevalence and impact on tumor development and progression are analyzed, focusing on the intricate molecular landscape of pancreatic cancer. In addition, this review underscores the prognostic significance of specific mutations, such as loss of TP53, and explores some potential targeted therapies tailored to these molecular signatures. The findings highlight the importance of genomic analyses for risk assessment, early detection and the design of personalized treatment approaches in pancreatic cancer. Overall, this review provides a comprehensive analysis of the molecular intricacies of pancreatic tumors, paving the way for more effective and tailored therapeutic interventions.
Design and Performance Assessment of a Label- free Biosensor utilizing a Novel TFET Configuration

The present study presents an innovative idea: an original design for a label-free biosensor utilizing H-shape channel configuration within a dielectrically modulated (DM) double-gate TFET (DGTFET) framework, which includes the incorporation of a drain pocket (DP). This design concept is introduced In this study, an analytical model for the DM DPDG-TFET has been created for the first time was formulated and subsequently verified through comparison with industry-standard simulation software (Silvaco TCAD). In this paper we have examine both the biosensor's sensitivity and its effectiveness when employed as a tunnel field-effect transistor (TFET) device. A comprehensive analysis of the device's performance has been conducted. The innovative configuration of the suggested TFET results in heightened sensitivity. Incorporating a drain pocket (DP) at the junction between the drain and channel effectively eliminates ambipolarity, showcasing a successful approach. The H-shape DM DPDGTFET design demonstrates its superiority over various devices documented in the literature. The presence or lack of electric charge in various biomolecules is examined in order to evaluate the device's sensitivity as a label-free biosensor.
The need for speed

One of the key enabling features of coherent Raman scattering (CRS) techniques is the dramatically improved imaging speed over conventional vibrational imaging methods. It is this enhanced imaging acquisition rate that has guided the field of vibrational microscopy into the territory of real‐time imaging of live tissues. In this feature article, we review several aspects of fast vibrational imaging and discuss new applications made possible by the improved CRS imaging capabilities. In addition, we reflect on the current limitations of CRS microscopy and look ahead at several new developments towards real‐time, hyperspectral vibrational imaging of biological tissues. (© 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Factors Affecting Length of Stay in a Stroke Unit After Intravenous Thrombolytic Therapy: A Retrospective Study

Objectives: This study aimed to examine the hospitalization duration in the stroke unit after IV thrombolytic therapy in acute ischemic stroke and the affecting factors. Methods: The research was designed as a retrospective study. From 334 patients admitted to a state hospital in Istanbul's stroke unit with a stroke diagnosis, 152 patients who received IV thrombolytic therapy constituted the study's sample. The hospital registry system, nurse observation notes, and patient files in the hospital archive were examined by the researcher to access the patients' socio-demographic and clinical data. Pearson correlation analysis was used to analyze the relationships between parameters conforming to a normal distribution, along with descriptive statistical methods. Results: The mean length of stay in the stroke unit was 3.2±3 days(2). Complications developed in 44.1% (67) of the patients during hospitalization. Among these complications, respiratory-related complications were the highest at 19.5% (13), followed by cerebral hemorrhage and cerebral edema at 18% (12). The most common reason for transferring patients was routine transfer at 82.3% (125). A statistically significant positive correlation was found (r=0.261; p<0.05) between the duration of stay in the stroke unit and the severity of the stroke. A positive (r=0.026; p<0.05) relationship was found between the stroke unit stay duration and the patient's age, and a negative relationship (r=-0.220; p<0.05) was found with the Glasgow Coma Scale before IV thrombolytic therapy. Conclusion: Short hospital stays and low mortality rates demonstrate the benefit of close observation of IV tPA patients. Complication development during stroke unit stay, stroke severity, age, as well as history of smoking and alcohol use in patients receiving IV thrombolytic therapy affect the length of hospital stay
Antifungal Activities of the Marine Green and Red Macro Algae Extracts Against Some Phytopathogenic Fungi

Plant pathogenic fungi, in particular are the source of several plant diseases,often regarded as one of the primary causes of decreased food supply around the world. The spread of such pathogenic fungi results in considerable crop losses degrades fruits and vegetables, reduces food availability, and costs billions of dollars annually. Although fungicides made of synthetic chemicals are commonly used for managing fungal diseases, they are harmful for the environment.
Characterisations of adverse events detected in a university hospital: a 4-year study using the Global Trigger Tool method

Objectives To describe the level, preventability and categories of adverse events (AEs) identified by medical record review using the Global Trigger Tool (GTT). To estimate when the AE occurred in the course of the hospital stay and to compare voluntary AE reporting with medical record reviewing. Design Two-stage retrospective record review. Setting 650-bed university hospital. Participants 20 randomly selected medical records were reviewed every month from 2009 to 2012. Primary and secondary outcome measures AE/1000 patient-days. Proportion of AEs found by GTT found also in the voluntary reporting system. AE categorisation. Description of when during hospital stay AEs occur. Results A total of 271 AEs were detected in the 960 medical records reviewed, corresponding to 33.2 AEs/1000 patient-days or 20.5% of the patients. Of the AEs, 6.3% were reported in the voluntary AE reporting system. Hospital-acquired infections were the most common AE category. The AEs occurred and were detected during the hospital stay in 65.5% of cases; the rest occurred or were detected within 30 days before or after the hospital stay. The AE usually occurred early during the hospital stay, and the hospital stay was 5 days longer on average for patients with an AE. Conclusions Record reviewing identified AEs to a much larger extent than voluntary AE reporting. Healthcare organisations should consider using a portfolio of tools to gain a comprehensive picture of AEs. Substantial costs could be saved if AEs were prevented.
Examining components of attitudes towards mathematics among senior secondary school students in Nigeria

The study investigated the components of attitudes towards mathematics among 1500 senior secondary school students from 20 co-educational public schools in the Lagos State of Nigeria using the quantitative research method within the blueprint of the descriptive survey design. Data collected using the component of attitudes toward mathematics scale (Cronbach alpha coefficient α=0.96) were analysed using the descriptive statistics of frequency count, percentage, mean, and standard deviation and inferential statistics of independent samples t-test and factor analysis. Findings revealed that senior secondary school students’ level of components of attitudes toward mathematics was at a moderate level. Components of attitudes towards mathematics scale was a multi-dimensional construct consisting of cognitive, behavioural and affective elements. Gender differences in components of attitudes towards mathematics among senior secondary school students were significant and in favour of the males. Based on this study, it was thus, recommended that future studies in Nigeria and elsewhere should investigate further the confirmatory factor analytic structure of the components of attitudes towards mathematics scale among senior secondary school students.
Negotiating Innovation: Product Renewal as the Outcome of a Complex Bargaining Process

In this paper, it is argued that innovation can be the result of a repetitive, multi-actor negotiation process. We present the case of an environment-related product innovation in a large multinational company that emerged as the outcome of a complex interaction process in which numerous external and internal actors negotiated to safeguard their own interests. This negotiation perspective challenges conventional economic views of innovations, in which new products and processes are regarded as exogenous variables, the outcomes of deliberately planned research, or the combination of technology (pushing) and market (pulling) inducements. Instead, innovation may be a non-linear, unpredictable process that involves multiple actors with divergent interests and that leads to outcomes that are collectively acceptable but not necessarily (sub)optimal.
Non-linear Metric Learning

In this paper, we introduce two novel metric learning algorithms, Χ2-LMNN and GB-LMNN, which are explicitly designed to be non-linear and easy-to-use. The two approaches achieve this goal in fundamentally different ways: Χ2-LMNN inherits the computational benefits of a linear mapping from linear metric learning, but uses a non-linear Χ2-distance to explicitly capture similarities within histogram data sets; GB-LMNN applies gradient-boosting to learn non-linear mappings directly in function space and takes advantage of this approach's robustness, speed, parallelizability and insensitivity towards the single additional hyper-parameter. On various benchmark data sets, we demonstrate these methods not only match the current state-of-the-art in terms of kNN classification error, but in the case of Χ2-LMNN, obtain best results in 19 out of 20 learning settings.
Compressing Proteomes: The Relevance of Medium Range Correlations

We study the nonrandomness of proteome sequences by analysing the correlations that arise between amino acids at a short and medium range, more specifically, between amino acids located 10 or 100 residues apart; respectively. We show that statistical models that consider these two types of correlation are more likely to seize the information contained in protein sequences and thus achieve good compression rates. Finally, we propose that the cause for this redundancy is related to the evolutionary origin of proteomes and protein sequences.
The Impact of Macroeconomic Events on Marketing Relationships

This paper addresses one issue that has been somewhat neglected in the marketing literature. Namely, whether basic marketing relationships at the establishment level are robust to major changes in the macroeconomic environment where they operate. What allows us to address this issue is a combination of two factors: passage of a law liberalizing retail gas prices in Spain and the availability of a survey of gas stations in Pamplona focusing on customer satisfaction and future patronage intentions prior to the passage of the law. By conducting a similar survey in 2007 we were able to ascertain the extent to which the main determinants of these two important marketing outcome variables were robust to the macroeconomic changes of the intervening years. While the main attributes or distribution services determining customer satisfaction were inter-temporally stable, customer perceptions of store price levels were not. In the case of future patronage intentions, only customer satisfaction was an inter-temporally stable determinant of the relationship. Important customer characteristics and objective characteristics of the establishments had different effects on future patronage intentions before and after the price liberalization.
Analysis of HPV distribution in patients with cervical precancerous lesions in Western China

Abstract Cervical human papillomavirus (HPV) infection is a dangerous disease, whose subtypes exhibit different distribution patterns in particular countries, regions, and races. In this study, the HPV distribution in patients with cervical precancerous lesions in Western China was investigated to assess a probability for prevention of cervical cancer and the clinical application of an HPV vaccine in China. The retrospective study of patients with different HPV subtypes and cervical precancerous lesions, who have undergone loop eelectrosurgical excision procedure, cold knife conization, or a total hysterectomy in our hospital from January 2016 to August 2016, was performed. All patients were tested for 27 HPV subtypes via the liquid suspension chip technology (Luminex 200). A total of 3393 cases of cervical intraepithelial neoplasia (CIN) were investigated, including 1098 cases of CIN I, 762 cases of CIN II, and 1533 cases of CIN III. The overall HPV infection rate was 82.58%. The high-risk HPV infection rate was 76.61%, and the low-risk rate was 9.88%. The most common 5 subtypes were HPV16, HPV52, HPV58, HPV33, and HPV18. The patients were grouped into 6 age groups: ⩽20, 21 to 30, 31 to 40, 41 to 50, 50 to 64, and ≥65. The HPV subtypes’ distribution varied across different age groups. In patients with cervical precancerous lesions in Western China, the top 5 HPV subtypes with the highest infection rates were HPV16, HPV52, HPV58, HPV33, and HPV18. The rate of cervical precancerous lesions unrelated to HPV was 17.42%. Thus, HPV screening with no cytology may leave unobserved about 20% of cervical precancerous lesions, which is worth of significant clinical attention.
Heroin inhibits HIV-restriction miRNAs and enhances HIV infection of macrophages

Although opioids have been extensively studied for their impact on the immune system, limited information is available about the specific actions of opioids on intracellular antiviral innate immunity against HIV infection. Thus, we investigated whether heroin, one of the most abused drugs, inhibits the expression of intracellular HIV restriction microRNA (miRNA) and facilitates HIV replication in macrophages. Heroin treatment of macrophages enhanced HIV replication, which was associated with the downregulation of several HIV restriction miRNAs. These heroin-mediated actions on the miRNAs and HIV could be antagonized by naltrexone, an opioid receptor antagonist. Furthermore, the in vitro negative impact of heroin on HIV-associated miRNAs was confirmed by the in vivo observation that heroin addicts had significantly lower levels of macrophage-derived HIV restriction miRNAs than those in the control subjects. These in vitro and in vivo findings indicate that heroin use compromises intracellular anti-HIV innate immunity, providing a favorable microenvironment for HIV survival in the target cells.
P-Selectin Glycoprotein Ligand-1 Is Expressed on Endothelial Cells and Mediates Monocyte Adhesion to Activated Endothelium

Objective—The purpose of this study was to investigate the presence and functionality of P-selectin glycoprotein ligand-1 (PSGL-1) on activated endothelial cells (ECs). Methods and Results—We show here that PSGL-1 is expressed at the mRNA and protein levels in umbilical vein and microvascular ECs. Furthermore, this endothelial PSGL-1 (ePSGL-1) is functional and mediates adhesion of monocytes or platelet-monocyte complexes (PMCs) to the activated endothelium in a flow model. ePSGL-1 expression was not affected by treating ECs with inflammatory stimuli (tumor necrosis factor α, interleukin-1β, thrombin, or histamine). However, the functional binding capacity of ePSGL-1 to monocytes or P-selectin/Fc chimera significantly increased by stimulation of the ECs with TNFα. By means of a siRNA approach to specifically knock-down the genes involved in the glycosylation of PSGL-1 we could show that tumor necrosis factor α–induced glycosylation of ePSGL-1 is critical for its binding capacity. Conclusion—Our results show that ECs express functional PSGL-1 which mediates tethering and firm adhesion of monocytes and platelets to inflamed endothelium.
Subunit composition of VRAC channels determines substrate specificity and cellular resistance to Pt‐based anti‐cancer drugs

Although platinum‐based drugs are widely used chemotherapeutics for cancer treatment, the determinants of tumor cell responsiveness remain poorly understood. We show that the loss of subunits LRRC8A and LRRC8D of the heteromeric LRRC8 volume‐regulated anion channels (VRACs) increased resistance to clinically relevant cisplatin/carboplatin concentrations. Under isotonic conditions, about 50% of cisplatin uptake depended on LRRC8A and LRRC8D, but neither on LRRC8C nor on LRRC8E. Cell swelling strongly enhanced LRRC8‐dependent cisplatin uptake, bolstering the notion that cisplatin enters cells through VRAC. LRRC8A disruption also suppressed drug‐induced apoptosis independently from drug uptake, possibly by impairing VRAC‐dependent apoptotic cell volume decrease. Hence, by mediating cisplatin uptake and facilitating apoptosis, VRAC plays a dual role in the cellular drug response. Incorporation of the LRRC8D subunit into VRAC substantially increased its permeability for cisplatin and the cellular osmolyte taurine, indicating that LRRC8 proteins form the channel pore. Our work suggests that LRRC8D‐containing VRACs are crucial for cell volume regulation by an important organic osmolyte and may influence cisplatin/carboplatin responsiveness of tumors.
Consumption Commitments and Risk Preferences

Many households devote a large fraction of their budgets to "consumption commitments" -- goods that involve transaction costs and are infrequently adjusted. This paper characterizes risk preferences in an expected utility model with commitments. We show that commitments affect risk preferences in two ways: (1) they amplify risk aversion with respect to moderate-stake shocks and (2) they create a motive to take large-payoff gambles. The model thus helps resolve two basic puzzles in expected utility theory: the discrepancy between moderate-stake and large-stake risk aversion and lottery playing by insurance buyers. We discuss applications of the model such as the optimal design of social insurance and tax policies, added worker effects in labor supply, and portfolio choice. Using event studies of unemployment shocks, we document evidence consistent with the consumption adjustment patterns implied by the model.
A dose–response study of salivary cortisol after dexamethasone suppression test in Cushing's disease and its potential use in the differential diagnosis of Cushing's syndrome

objective A dose–response study with different doses of dexamethasone (dex) to assess the corticotrophic resistance in Cushing's disease (CD) using salivary cortisol as an end point has not yet been evaluated. We also reported our experience with salivary cortisol compared to plasma cortisol determination during dex suppression test (DST) and after ovine corticotrophin release hormone (oCRH) test in the differential diagnosis of Cushing's syndrome (CS).
Coe Genes Are Expressed in Differentiating Neurons in the Central Nervous System of Protostomes

Genes of the coe (collier/olfactory/early B-cell factor) family encode Helix-Loop-Helix transcription factors that are widely conserved in metazoans and involved in many developmental processes, neurogenesis in particular. Whereas their functions during vertebrate neural tube formation have been well documented, very little is known about their expression and role during central nervous system (CNS) development in protostomes. Here we characterized the CNS expression of coe genes in the insect Drosophila melanogaster and the polychaete annelid Platynereis dumerilii, which belong to different subgroups of protostomes and show strikingly different modes of development. In the Drosophila ventral nerve cord, we found that the Collier-expressing cells form a subpopulation of interneurons with diverse molecular identities and neurotransmitter phenotypes. We also demonstrate that collier is required for the proper differentiation of some interneurons belonging to the Eve-Lateral cluster. In Platynereis dumerilii, we cloned a single coe gene, Pdu-coe, and found that it is exclusively expressed in post mitotic neural cells. Using an original technique of in silico 3D registration, we show that Pdu-coe is co-expressed with many different neuronal markers and therefore that, like in Drosophila, its expression defines a heterogeneous population of neurons with diverse molecular identities. Our detailed characterization and comparison of coe gene expression in the CNS of two distantly-related protostomes suggest conserved roles of coe genes in neuronal differentiation in this clade. As similar roles have also been observed in vertebrates, this function was probably already established in the last common ancestor of all bilaterians.
Human activity was a major driver of the mid‐Holocene vegetation change in southern Cumbria: implications for the elm decline in the British Isles

The dramatic decline in elm (Ulmus) across a large swathe of north‐west Europe in the mid‐Holocene has been ascribed to a number of possible factors, including climate change, human activity and/or pathogens. A major limitation for identifying the underlying cause(s) has been the limited number of high‐resolution records with robust geochronological frameworks. Here, we report a multiproxy study of an upland (Blea Tarn) and lowland (Urswick Tarn) landscape in southern Cumbria (British Isles) to reconstruct vegetation change across the elm decline in an area with a rich and well‐dated archaeological record to disentangle different possible controls. Here we find a two‐stage decline in Ulmus taking place between 6350–6150 and 6050–5850 cal a BP, with the second phase coinciding with an intensification of human activity. The scale of the decline and associated human impact is more abrupt in the upland landscape. We consider it likely that a combination of human impact and disease drove the Ulmus decline within southern Cumbria.