Miracle-dz/UniFAR-FTUs huggingface dataset:
A Metazoan/Plant-like Capping Enzyme and Cap Modified Nucleotides in the Unicellular Eukaryote Trichomonas vaginalis

The cap structure of eukaryotic messenger RNAs is initially elaborated through three enzymatic reactions: hydrolysis of the 5′-triphosphate, transfer of guanosine through a 5′-5′ triphosphate linkage and N7-methylation of the guanine cap. Three distinctive enzymes catalyze each reaction in various microbial eukaryotes, whereas the first two enzymes are fused into a single polypeptide in metazoans and plants. In addition to the guanosine cap, adjacent nucleotides are 2′-O-ribose methylated in metazoa and plants, but not in yeast. Analyses of various cap structures have suggested a linear phylogenetic trend of complexity. These findings have led to a model in which plants and metazoa evolved a two-component capping apparatus and modification of adjacent nucleotides while many microbial eukaryotes maintained the three-component system and did not develop modification of adjacent nucleotides. Here, we have characterized a bifunctional capping enzyme in the divergent microbial eukaryote Trichomonas vaginalis using biochemical and phylogenetic analyses. This unicellular parasite was found to harbor a metazoan/plant-like capping apparatus that is represented by a two-domain polypeptide containing a C-terminus guanylyltransferase and a cysteinyl phosphatase triphosphatase, distinct from its counterpart in other microbial eukaryotes. In addition, T. vaginalis mRNAs contain a cap 1 structure represented by m7GpppAmpUp or m7GpppCmpUp; a feature typical of metazoan and plant mRNAs but absent in yeast mRNAs. Phylogenetic and biochemical analyses of the origin of the T. vaginalis capping enzyme suggests a complex evolutionary model where differential gene loss and/or acquisition occurred in the development of the RNA capping apparatus and cap modified nucleotides during eukaryote diversification.
RELATIONSHIP AMONG BRANDING, CAREER DEVELOPMENT AND TOURISM EDUCATION: AN IMPLICATION FROM TURKEY

The purpose of this study was to investigate possible impacts of branding of hotel enterprises on the career development of students in tourism education. A questionnaire was used to collect empirical data. The population of the research included the 3 rd and 4 th year students. Four tourism education institutions were selected and 450 students participated in the survey. Overall 392 valid questionnaires were taken into considerations. This paper reports the majority of the students have negative views and expectations and attitudes towards the tourism industry in Turkey. The findings show that a branded hotel enterprise can make significant contribution in helping students of tourism and hospitality management education professional approach to the industry in a more professional way and to solution of the most important problems suffered in relation to the hotel work mentioned in the context.
Graduates' Construction Systems and Career Development

The paper draws on the Chicago School's conceptualization of career and on Personal Construct Psychology to examine the relationships between graduates' construction systems and patterns of career development during the first 4 years of employment. It seeks to identify differences in trends of constructive revision between "successful" and "less successful" graduates. The study is based on 33 graduates who completed repertory grids on entering employment (T1), 6 months later (72), and 4 years later (T3), re-eliciting constructs each time. The results show some significant change in the nature of the constructs elicited by graduates over the 4 years; in particular, graduates made greater use of constructs related to achievement, cynicism, and organizational politics. Graduates whose career was more "successful" (i.e., who experienced one or two promotions during the 4 years of the study and felt generally satisfied with their careers) were more likely to use constructs related to social behavior and flexibility at T1, while graduates whose career was "less sucessful" (i.e., no promotion and felt dissatisfied with their careers) were more likely to construe themselves in terms of achievement and work competence at T1. Four years on, "successful" graduates tended to rely more on constructs related to achievement and flexibility, while "less successful" graduates were more likely to use constructs related to social behavior. The significance and implications of these results for organizational recruitment and development practices are discussed.
Audience Activity and Television News Gratifications

The variable nature of audience activity was examined with a sample of 329 local television news viewers. Instrumental news viewing was expected to be related to audience intentionality, selectivity, and involvement with local news. Hierarchical regression found that affinity, selectivity, and involvement predicted intentionality; pass time motives, perceived realism, and reduced intentionality predicted nonselectivity; pass time motives and reduced affinity predicted distractions; and information and nonentertainment motives, perceived realism, and intentionality predicted involvement. Canonical correlation found two news viewing orientations. Instrumental use, or seeking exciting and entertaining information gratifications, was related positively to perceived news realism, affinity, intentionality, and involvement. Ritualized use, or more habitual and time-consuming viewing, was related negatively to news affinity, selectivity, and intentionality, and positively to coviewing distractions. Implications of the links between instrumental media use and audience activity for uses and effects research are discussed.
H∞ filter design for a class of networked control systems via T-S fuzzy model approach

This paper is concerned with H∞ filter design for a class of networked control systems (NCSs) with multiple state-delays via Takagi-Sugeno (T-S) fuzzy model. The transfer delays and packet loss which are induced by the limited bandwidth of communication networks, are considered. The focus of this paper is on the analysis and design of a full-order H∞ filter such that the filtering error dynamics is stochastically stable and a prescribed H∞ attenuation level is guaranteed. Sufficient conditions are established for the existence of the desired filter in terms of linear matrix inequalities (LMIs). An example is given to illustrate the effectiveness and applicability of the proposed design method.
Morphologically normal spermatozoa of patients with secretory oligo-astheno-teratozoospermia have an increased aneuploidy rate.

BACKGROUND Normal morphology is a major criterion for selecting spermatozoa to be injected. Given that teratozoospermia is one of the most critical parameters associated with sperm aneuploidy, the purpose of this study was to evaluate the aneuploidy rate of morphologically normal spermatozoa of patients with oligo-astheno-teratozoospermia (OAT). METHODS Ten patients with secretory OAT and six age-matched normozoospermic men with a normal karyotype were enrolled. After assignment to normal or abnormal category, the location of each spermatozoon was recorded using an electronic microstage locator. Slides were then subjected to triple-colour fluorescence in situ hybridization for chromosomes X, Y and 12. RESULTS OAT patients had a lower number of morphologically normal and abnormal spermatozoa carrying the X chromosome, compared with normozoospermic men. They also exhibited increased XY and XX disomy rates. Morphologically abnormal spermatozoa from normozoospermic men also had an increased XX disomy rate compared with normally shaped spermatozoa obtained from the same men. The total sperm aneuploidy rate of morphologically abnormal spermatozoa of normozoospermic men was 4.4-fold higher than that of spermatozoa with normal morphology. The total aneuploidy rates of spermatozoa with normal or abnormal head shape from OAT patients were similar to each other and to that of abnormally shaped spermatozoa from normozoospermic men, but they were higher than the rate found in normally shaped spermatozoa of normal men. CONCLUSIONS Normally shaped spermatozoa of OAT patients have an increased aneuploidy rate.
European assignments: international or quasi‐domestic?

Seeks to investigate the adjustment of business relocatees to their host environment. It explores the facets of the relocatees’ adjustment in the following three regions: Germany as the home country and destination for domestic assignments, Western Europe and other countries. It further investigates the stress levels the relocatees display and their motives for accepting or actively seeking relocation. If the results of this survey suggest the existence of Western Europe as a distinct assignment location, these findings will form a valuable basis for the development of policies for intra‐European personnel transfers, particularly in the area of selection, training, development and compensation.
Just need some satisfaction: examining the relationship between passion for exercise and the basic psychological needs

Individuals often pursue activities for which they are passionate about, and this passion is operationalized as being harmonious (an autonomous desireto engage in the activity) or obsessive (a controlled desire to engage in the activity) in nature (Vallerand et al., 2003). With regard to harmonious passion, Vallerand et al. (2003) suggests that it is fostered in environments that nurture innate needs for autonomy, competence, and relatedness. The purpose of the present study was to explore the nature of the passion-basic psychological needs (competence, autonomy, relatedness) relationship. Kinesiology students (N = 917; Mage = 18.54 SD = 1.66) completed the Passion Scale (Vallerand et al., 2003) and the Psychological Need Satisfaction in Exercise Scale (Wilson et al., 2006). Results from the SEM path analysis indicated that harmonious passion was positively related to competence (SPE = .43) and relatedness (SPE = .43) and obsessive passion was negatively related to autonomy (SPE = -.18)(CFI = .90, RMSEA = .07, SRMR = .07). Implications for exercise participation/enjoyment are discussed.
THE POWER OF FILIAL RELATIONSHIP ENHANCEMENT THERAPY AS AN INTERVENTION IN CHILD ABUSE AND NEGLECT

Identified variables that influence intervention in child abuse and neglect and proposes a constructive approach that can help these children and their families change. This is a difficult and complex societal problem, and it is difficult to tease out the specific elements that are responsible for the frequency of its occurrence. The family context is often recognized as having a significant influence. Filial Relationship Enhancement, using an improved family context to support gains, has a long history of research and practice to support its efficacy to intervene in difficulties that impede optimum functioning in children. Filial Relationship Enhancement helps parents learn to conduct weekly child-centered play therapy sessions with their own children at home. This article presents the basic assumptions and the rationale for considering the potential power of this approach. It also describes a program of intervention incorporated by a child protective unit of a county agency. Using informal measures, outcomes are described as well. (PsycINFO Database Record (c) 2012 APA, all rights reserved)
Role Patterns in Group Supervision

Abstract An analysis was made of 22 supervision groups in two psychotherapy training programmes at different levels. Its main focus concerned role patterns based on self-image ratings and changes over time. The results showed no significant differences between the two categories of supervisees, whereas the differences between the supervisors and the supervisees, independent of level of training, were highly significant. The results indicate that it is just as difficult to find one's voice and role in a supervision group at an advanced as at a basic level. For the supervisors the result was interpreted in terms of their roles in relation to the supervisees and the aim of the supervision.
Assessing School Achievement Progress: Comparing Alternative Approaches

Purpose : Currently under the No Child Left Behind Act, cut scores of successive cohorts of students are used to identify schools that are successful and others that are failing. For many schools, however, this score does not provide an accurate, fair, or comprehensive performance assessment. The focus of this study is to compare three alternative approaches for estimating student progress with respect to their accuracy, equity, and usefulness in making inferences about school effectiveness. Research Design : The study compares achievement estimates compiled across a 4-year period from successive and longitudinal cohorts in a multilevel sample of 123 elementary schools and several thousand students. Findings : First, method effects associated with the designs interact with estimates of school effectiveness. Less than 20% of the schools are similarly identified as meeting performance standards across all three designs investigated. Second, in each approach, contextual indicators (e.g., student composition) dominate in explaining between-school differences in proficiency levels. Third, the longitudinal-cohort approach provides more comprehensive results about performance because of the simultaneous focus on student proficiency and growth. Equity and usefulness are also increased in comparisons of student growth because student composition and context effects are diminished and, conversely, process effects (e.g., academic expectations) are increased in explaining school differences. Conclusions : The comparisons suggest caution in making decisions about schools based on proficiency levels because both method effects and extraneous variables interact with the validity of estimates obtained. Modeling students' growth trajectories, however, can uncover positive school results that are missed in the current proficiency-status approach.
Ubiquitous Inequality: The Home Market Effect in a Multicountry Space

We show that spatial inequalities in an economic space of multiple countries in terms of both nominal income and real income are ubiquitous in the sense that they appear when countries are differentiated by population only. A new trade theory model is constructed without any freely traded homogeneous good, so that we can examine the home market effect (HME) and the non-monotonic relation between income inequalities and globalization. Meanwhile, there are three HME definitions for a two-country space in terms of firm share, labor wage, and trade pattern. The first two remain applicable in a multicountry space, and they are shown to be equivalent. However, a natural extension of the third is not equivalent.
On the Determination of Magnesium Degradation Rates under Physiological Conditions

The current physiological in vitro tests of Mg degradation follow the procedure stated according to the ASTM standard. This standard, although useful in predicting the initial degradation behavior of an alloy, has its limitations in interpreting the same for longer periods of immersion in cell culture media. This is an important consequence as the alloy’s degradation is time dependent. Even if two different alloys show similar corrosion rates in a short term experiment, their degradation characteristics might differ with increased immersion times. Furthermore, studies concerning Mg corrosion extrapolate the corrosion rate from a single time point measurement to the order of a year (mm/y), which might not be appropriate because of time dependent degradation behavior. In this work, the above issues are addressed and a new methodology of performing long-term immersion tests in determining the degradation rates of Mg alloys was put forth. For this purpose, cast and extruded Mg-2Ag and powder pressed and sintered Mg-0.3Ca alloy systems were chosen. DMEM Glutamax +10% FBS (Fetal Bovine Serum) +1% Penicillin streptomycin was used as cell culture medium. The advantages of such a method in predicting the degradation rates in vivo deduced from in vitro experiments are discussed.
Implicit and explicit measures of prejudice and stereotyping: do they assess the same underlying knowledge structure?

Do implicit and explicit measures of ethnic attitudes assess the same underlying knowledge structure in long term memory? This study uses both a correlational and an experimental design (N ¼133) in order to address this central question. In the first part, we suggest that self-presentational strategies can partly explain why the relation between implicit and explicit measures is inconsistent in the existing literature. More specifically, we show that when there are strong norms against prejudice, implicit and explicit measures are significantly negatively related. In the second part, an experimental manipulation of relative gratification (RG), the opposite of relative deprivation, reveals that when the level of explicit prejudice increases (RG condition), a similar effect is also observed at the implicit level. Together, these results suggest that implicit and explicit measures assess similar knowledge structure. Copyright # 2004 John Wiley & Sons, Ltd. A substantial number of studies have now shown that it is possible to obtain measures of prejudice and stereotyping outside of the individual’s control and awareness (e.g. see Wittenbrink, Judd, & Park, 2001). Implicit attitudes are assumed to operate in an unconscious mode, reflecting an automatic mental process. On the other hand, explicit measures of attitudes operate in a conscious fashion and are almost entirely under the control of the respondent (Wilson, Lindsey, & Schooler, 2000). One important theoretical question raised by this work concerns the extent to which implicit and explicit techniques assess the same underlying knowledge structure in long-term memory. We propose to examine this question using two different methodological approaches. The first approach seeks an answer by studying the relationship between implicit and explicit attitudes. However, another approach can also be used to answer this fundamental question. Research in social psychology has identified several factors that can explain why people are prejudiced (e.g. see Brown, 1995; Fiske, 2000). If we manipulate one of these factors, we should therefore expect a higher level of prejudice in the group in which this factor is introduced. If implicit and explicit measures of prejudice assess a similar construct in long term memory, then we should observe a parallel effect on these two measures. We will develop this experimental approach in the second part of the paper.
Craving Facebook? Behavioral addiction to online social networking and its association with emotion regulation deficits.

AIMS To assess disordered online social networking use via modified diagnostic criteria for substance dependence, and to examine its association with difficulties with emotion regulation and substance use. DESIGN Cross-sectional survey study targeting undergraduate students. Associations between disordered online social networking use, internet addiction, deficits in emotion regulation and alcohol use problems were examined using univariate and multivariate analyses of covariance. SETTING A large University in the Northeastern United States. PARTICIPANTS Undergraduate students (n = 253, 62.8% female, 60.9% white, age mean = 19.68, standard deviation = 2.85), largely representative of the target population. The response rate was 100%. MEASUREMENTS Disordered online social networking use, determined via modified measures of alcohol abuse and dependence, including DSM-IV-TR diagnostic criteria for alcohol dependence, the Penn Alcohol Craving Scale and the Cut-down, Annoyed, Guilt, Eye-opener (CAGE) screen, along with the Young Internet Addiction Test, Alcohol Use Disorders Identification Test, Acceptance and Action Questionnaire-II, White Bear Suppression Inventory and Difficulties in Emotion Regulation Scale. FINDINGS Disordered online social networking use was present in 9.7% [n = 23; 95% confidence interval (5.9, 13.4)] of the sample surveyed, and significantly and positively associated with scores on the Young Internet Addiction Test (P < 0.001), greater difficulties with emotion regulation (P = 0.003) and problem drinking (P = 0.03). CONCLUSIONS The use of online social networking sites is potentially addictive. Modified measures of substance abuse and dependence are suitable in assessing disordered online social networking use. Disordered online social networking use seems to arise as part of a cluster of symptoms of poor emotion regulation skills and heightened susceptibility to both substance and non-substance addiction.
An Interactionist Perspective on Interpersonal Dependency

Interpersonal dependency—the tendency to look to others for nurturance, guidance, protection, and support, even in situations where autonomous functioning is possible—has become associated with passivity, immaturity, and dysfunction in the minds of mental health professionals. However, research suggests that dependent persons behave quite actively—even aggressively—in certain contexts. Although dependency is associated with certain forms of dysfunction (e.g., perpetration of domestic violence when close relationships are threatened), it is also linked with an array of adaptive behaviors (e.g., conscientiousness in complying with medical and psychotherapeutic treatment regimens). The cognitive/interactionist (C/I) model of interpersonal dependency provides a framework for understanding contextual variations in dependency-related responding: Although dependent behaviors vary from situation to situation based on perceived opportunities and risks, the dependent person’s core beliefs (a perception of oneself as helpless and weak) and motives (a desire to strengthen ties to potential caregivers) remain constant. Here I discuss theoretical and practical implications of the C/I model and summarize current trends in research on interpersonal dependency.
Trauma, PTSD, and substance use disorders: findings from the Australian National Survey of Mental Health and Well-Being.

OBJECTIVE The aim of the present study was to examine the association between trauma and posttraumatic stress disorder (PTSD) and substance use disorders and to examine the correlates of substance use disorder plus PTSD comorbidity in the Australian general population. METHOD Data were collected from a stratified sample of 10,641 participants as part of the Australian National Survey of Mental Health and Well-Being. A modified version of the Composite International Diagnostic Interview was used to determine the presence of DSM-IV anxiety, affective, and substance use disorders and ICD-10 personality disorders. RESULTS Substance use disorder plus PTSD was experienced by a significant minority of the Australian general population (0.5%). Among those with PTSD, the most common substance use disorder was an alcohol use disorder (24.1%), whereas among those with a substance use disorder, PTSD was most common among individuals with an opioid use disorder (33.2%). Consistent with U.S. clinical literature, individuals with substance use disorder plus PTSD experience significantly poorer physical and mental health and greater disability than those with substance use disorder alone. In contrast, individuals with PTSD alone and those with substance use disorder plus PTSD shared a remarkably similar clinical profile. CONCLUSIONS It is important that individuals entering treatment for substance use disorder or PTSD be assessed for this comorbidity. The addition of either disorder may present complications that need to be considered for the provision of appropriate treatment. Further research is necessary to ascertain which treatments are most effective in treating comorbid substance use disorder plus PTSD.