Miracle-dz/UniFAR-FTUs huggingface dataset:
Consensus-based distributed principal component analysis in wireless sensor networks

Principal component analysis is a powerful technique for data analysis and compression, with a wide range of potential applications in wireless sensor networks. However, its centralized implementation, with a fusion center collecting all the samples, is inefficient in terms of energy consumption, scalability, and fault tolerance. Previous distributed approaches reduce the communication cost, but not the lack of flexibility, as they require multi-hop communications if the network is not fully connected. We present two fully distributed consensus-based algorithms that are guaranteed to converge to the global results, using only local communications among neighbors, regardless of the data distribution or the sparsity of the network: CB-DPCA is based on finding the eigenvectors of local covariance matrices, while CB-EM-DPCA is a distributed version of the expectation maximization algorithm. Both offer a flexible trade-off between the tightness of the achieved approximation and the associated communication cost.
Auxin patterns Solanum lycopersicum leaf morphogenesis

One of the most striking aspects of plant diversity is variation in leaf shape. Much of this diversity is achieved by the modulation of leaf blade dissection to form lobes or leaflets. Here, we show that the phytohormone auxin is a crucial signal regulating the partitioned outgrowth necessary to develop a dissected leaf. In developing leaves, the asymmetric distribution of auxin, driven by active transport, delineates the initiation of lobes and leaflets and specifies differential laminar outgrowth. Furthermore, homologous members of the AUX/indole-3-acetic acid (IAA) gene family mediate the action of auxin in determining leaf shape by repressing outgrowth in areas of low auxin concentration during both simple and compound leaf development. These results provide molecular evidence that leaflets initiate in a process reminiscent of organogenesis at the shoot apical meristem, but that compound and simple leaves regulate marginal growth through an evolutionarily conserved mechanism, thus shedding light on the homology of compound and simple leaves.
Selenium Promotes T-Cell Response to TCR-Stimulation and ConA, but Not PHA in Primary Porcine Splenocytes

There is controversy in the literature over whether the selenium (Se) influences cellular immune responses, and the mechanisms possibly underlying these effects are unclear. In this study, the effects of Se on T-cell proliferation and IL-2 production were studied in primary porcine splenocytes. Splenocytes were treated with different mitogens in the presence of 0.5–4 µmol/L sodium selenite. Se significantly promoted T-cell receptor (TCR) or concanavalin A (ConA)-induced T-cell proliferation and IL-2 production but failed to regulate T-cell response to phytohemagglutinin (PHA). In addition, Se significantly increased the levels of cytosolic glutathione peroxidase (GPx1) and thioredoxin reductase 1 (TR1) mRNA, the activity of GPx1 and the concentration of reduced glutathione (GSH) in the unstimulated, or activated splenocytes. These results indicated that Se improved the redox status in all splenocytes, including unstimulated, TCR, ConA and PHA -stimulated, but only TCR and ConA-induced T-cell activation was affected by the redox status. N-acetylcysteine (NAC), a pharmacological antioxidant, increased T-cell proliferation and IL-2 production by TCR and ConA stimulated splenocytes but had no effect on the response to PHA in primary porcine splenocytes confirming that PHA-induced T-cell activation is insensitive to the redox status. We conclude that Se promotes GPx1 and TR1 expression and increases antioxidative capacity in porcine splenocytes, which enhances TCR or ConA -induced T-cell activation but not PHA-induced T-cell activation. The different susceptibilities to Se between the TCR, ConA and PHA -induced T-cell activation may help to explain the controversy in the literature over whether or not Se boosts immune responses.
Somatic Experiencing treatment with tsunami survivors in Thailand: Broadening the scope of early intervention.

follow-up, 90% of participants had complete or partial improvement in reported symptoms, and 96% had complete or partial improvement in initially observed symptoms. Given the small sample size and lack of an equivalent comparison group, results must be interpreted with caution. Nonetheless, the results suggest that integrative mind–body interventions have promise in disaster treatment.
Increased serum oxidized low-density lipoprotein levels in pregnancies complicated by gestational diabetes mellitus

Background: Elevated serum levels of oxidized Low-density Lipoprotein (oxLDL) have been found in type 2 and in poorly controlled diabetic patients. Gestational diabetes mellitus (GDM) has common features with type 2 diabetes. Objective: The aim of our study was to evaluate the serum levels of oxLDL in women with GDM compared to normal pregnant women. Materials and Methods: In this cross-sectional study, ninety-two subjects were randomly allocated to either GDM (n=46) or control (n=46) groups matched for age, body mass index and parity from March 2013 to March 2014. GDM was diagnosed according to the American Diabetes Association criteria at 24-26 weeks of gestation. OxLDL was measured using enzyme-linked immunosorbent assay. T-test and Pearson correlation coefficients were applied for analyzing the data by using SPSS version 17. Results: Compared to the controls, significantly higher oxLDL levels were found in the GDM group (17.16 ± 3.71 U/L vs. 8.77 ± 1.84 U/L, respectively, p < 0.001). No significant correlations were found between oxLDL and age and BMI of the patients in the groups. Conclusion: Our study found significant increase of oxLDL in GDM emphasizing the role of short-term hyperglycemia in the formation of oxLDL during GDM. The importance of aptly diagnosis of GDM in maternal health may also be concluded.
Health and Health Care Utilization among Obese and Diabetic Baby Boomers and Older Adults

Purpose. Examine how sociodemographic, health, behavioral, and health care utilization factors are associated with being obese or having diabetes among baby boomers and older adults. Design. Cross-sectional data were drawn from the 2007–2008 National Health and Nutrition Examination Survey. Setting. United States. Subjects. A sample of 3439 baby boomers and older adults included (mean age, 62 years). Measures. Covariates included sociodemographics, health outcomes, behaviors, and inpatient and outpatient health care utilization. Analysis. Multinomial logistic regression was used to explore which similar or different covariates were associated with different health states between baby boomers and older adults. Results. Approximately 8% of baby boomers and 10% of older adults had the twin diagnoses of obesity and diabetes. Having both obesity and diabetes was more common among baby boomers and older adults who were African-American (odds ratio [OR] = 1.79, p = .029 for baby boomers; OR = 3.45, p < .001 for older adults), perceived their general health as fair/poor (OR = 7.67, p < .001; OR = 4.13, p < .001), and utilized outpatient care more often (OR = 8.28, p < .001; OR = 5.35, p = .004). Being obese only was observed less among baby boomers who were current smokers (OR = .45, p < .001), whereas it was observed more among older adults who were former smokers (OR = 1.25, p = .046). Having diabetes only was observed more among baby boomers who had hypertension (OR = 2.44, p = .01), whereas it was observed more among older adults who had very high cholesterol (OR = 2.31, p = .029). Conclusion. Identifying chronic disease risk factors during middle age is important for ameliorating further complications in later life. Knowing more about the correlates of obesity and diabetes among different age groups can help health care planners better target preventive health care services.
Prevalence and common genotypes of HCV infection in Sudanese patients with hepatosplenic schistosomiasis

A cross‐sectional hospital based study was carried out at the National Center for Gastrointestinal and Liver Disease in Khartoum, Sudan to determine the prevalence, common genotypes and risk factors for hepatitis C virus infection in Sudanese patients with hepatosplenic schistosomiasis. A total of 176 patients with hepatosplenic schistosomiasis were tested for HCV antibodies and 4.5% of the samples were reactive. PCR was positive in 2.3% of cases and genotype 4 was the major genotype isolated with subtypes 4, 4e, and 4c/4d. It is concluded that HCV was of low seroprevalence in the study population and that parenteral antischistosomal therapy was not a significant risk factor in transmission of infection in the Sudan. J. Med. Virol. 79:1322–1324, 2007. © Wiley‐Liss, Inc.
Photometric properties of galaxy population in the cluster EIS 0048-2942 at z ∼ 0.64

Deep photometric data in the V -, R -, I -, z - and K -bands for the cluster of galaxies EIS 0048-2942 are used to investigate the properties of the galaxy populations at ${z\sim0.64}$ in a field of $\mathrm{2.5\times 2.5~Mpc^2}$. The sample of candidate cluster members (${N = 171}$) is selected by the photometric redshift technique and is complete up to $I=22.5$. Galaxies were classified as spheroids and disks according to the shape of the light profile in the I -band, as parametrized by the Sersic index. In both optical and NIR, spheroids define a sharp colour-magnitude sequence, whose slope and zero points are consistent with a high formation redshift (${z_{\rm f} > 2}$). The disk population occupies a different region in the colour-magnitude diagram, having bluer colours with respect to the red sequence. Interestingly, we find some level of mixing between the properties of the two classes: some disks lie on the colour-magnitude sequence or are redder, while some spheroids turn out to be bluer. The spatial distribution of cluster galaxies shows a clumpy structure, with a main over-density of radius ~$0.5~$Mpc, and at least two other clumps distant ~1 Mpc from the center. The various sub-structures are mostly populated by the red galaxies, while the blue population has an almost uniform distribution. The fraction of blue galaxies in EIS 0048-2942 is $f_B=0.11 \pm 0.07$. This is much lower than what expected on the basis of the Butcher-Oemler effect at lower redshifts.
Assessment of Diffuse Myocardial Fibrosis in Rats Using Small-Animal Look-Locker Inversion Recovery T1 Mapping

Background— The concentration of gadopentetate dimeglumine in myocardium and blood can be assessed from T1 measurements and can be used to calculate the extracellular volume (ECV) of the myocardium. We hypothesized that diffuse myocardial fibrosis in a small-animal model could be quantitatively assessed by measuring myocardial ECV using small-animal Look-Locker inversion recovery T1 mapping. Methods and Results— Sprague-Dawley rats (n=10) were subjected to continuous angiotensin-2 (AT2) infusion for 2 weeks via a subcutaneously implanted minipump system. Magnetic resonance imaging (MRI) was performed both before and after AT2 infusion. The MRI protocol included multislice cine imaging and before-and-after contrast small-animal Look-Locker inversion recovery T1 mapping and late gadolinium enhancement imaging. Myocardial ECV was calculated from hematocrit and T1 values of blood and myocardium. During the course of AT2 infusion, the mean±SD systolic blood pressure increased from 122±10.9 to 152±27.5 mm Hg (P=0.003). Normalized heart weight was significantly higher in AT2-treated animals than in control littermates (P=0.033). Cine MRI documented concentric left ventricular hypertrophy. Postcontrast myocardial T1 times were shortened after treatment (median [interquartile range], 712 [63] versus 820 [131] ms; P=0.002). Myocardial ECV increased from 17.2% (4.3%) before to 23.0% (6.2%) after AT2 treatment (P=0.031), which was accompanied by perivascular fibrosis and microscarring on myocardial histological analysis. There was a moderate level of correlation between ECV and collagen volume fraction, as assessed by histological analysis (r=0.69, P=0.013). Conclusions— In a small-animal model of left ventricular hypertrophy, contrast-enhanced T1 mapping can be used to detect diffuse myocardial fibrosis by quantification of myocardial ECV.
Integrative Survival-Based Molecular Profiling of Human Pancreatic Cancer

Purpose: To carry out an integrative profile of human pancreatic ductal adenocarcinoma (PDAC) to identify prognosis-significant genes and their related pathways. Experimental Design: A concordant survival-based whole genome in silico array analysis of DNA copy number, and mRNA and miRNA expression in 25 early-stage PDAC was carried out. A novel composite score simultaneously integrated gene expression with regulatory mechanisms to identify the signature genes with the most levels of prognosis-significant evidence. The predominant signaling pathways were determined via a pathway-based approach. Independent patient cohorts (n = 148 and 42) were then used as in vitro validation of the array findings. Results: The composite score identified 171 genes in which expressions were able to define two prognosis subgroups (P = 3.8e-5). Eighty-eight percent (151 of 171) of the genes were regulated by prognosis-significant miRNAs. The phosphoinositide 3-kinase/AKT pathway and SRC signaling were densely populated by prognosis-significant genes and driven by genomic amplification of SRC and miRNA regulation of p85α and CBL. On tissue microarray validation (n = 148), p85α protein expression was associated with improved survival for all patients (P = 0.02), and activated P-SRC (Y418) was associated shorter survival for patients with low-grade histology tumors (P = 0.04). Interacting P-SRC and p85α revealed that they define two distinct PDAC patient subgroups (P = 0.0066). Furthering the importance of these pathways, CBL protein expression was associated with improved survival (P = 0.03) on a separate cohort (n = 42). Conclusions: These pathways and related genes may represent putative clinical biomarkers and possible targets of individualized therapy in the distinct patient subgroups they define. Clin Cancer Res; 18(5); 1352–63. ©2012 AACR.
Improved LCU level rate control for 3D-HEVC

In this paper, we propose an improved Largest Coding Unit (LCU) level rate control algorithm for the 3D video coding extension of the high efficiency video coding (3D-HEVC). In the proposed algorithm, bit allocation for extended views is investigated in combination with temporal and inter-view Mean Absolute Difference (MAD) predictions. Upon prediction weights generated by MAD prediction errors, accurate bitrate for LCU can be obtained. Then, a weight-based R-λ model is designed based on the prediction weights by improving the model parameters consistent with video content. Experimental results show that the proposed algorithm can achieve better rate distortion performance and bitrate accuracy in comparison with the R-λ model based rate control benchmark algorithm in HTM.
One-and-a-halfth-order logic

The practice of first-order logic is replete with meta-level concepts. Most notably there are the meta-variables themselves (ranging over predicates, variables, and terms), assumptions about freshness of variables with respect to these meta-variables, alpha-equivalence and capture-avoiding substitution. We present one-and-a-halfth-order logic, in which these concepts are made explicit. We exhibit both algebraic and sequent specifications of one-and-a-halfth-order logic derivability, show them equivalent, show that the derivations satisfy cut-elimination, and prove correctness of an interpretation of first-order logic within itWe discuss the technicalities in a wider context as a case-study for nominal algebra, as a logic in its own right, as an algebraisation of logic, as an example of how other systems might be treated, and also as a theoretical foundation for future implementation.
Gene Expression Profiling in Response to Ultraviolet Radiation in Maize Genotypes with Varying Flavonoid Content 1 [ w ]

Microarray hybridization was used to assess acclimation responses to four UV regimes by near isogenic maize (Zea mays) lines varying in flavonoid content. We found that 355 of the 2,500 cDNAs tested were regulated by UV radiation in at least one genotype. Among these, 232 transcripts are assigned putative functions, whereas 123 encode unknown proteins. UV-B increased expression of stress response and ribosomal protein genes, whereas photosynthesis-associated genes were down-regulated; lines lacking UV-absorbing pigments had more dramatic responses than did lines with these pigments, confirming the shielding role of these compounds. Sunlight filtered to remove UV-B or UV-B plus UV-A resulted in significant expression changes in many genes not previously associated with UV responses. Some pathways regulated by UV radiation are shared with defense, salt, and oxidative stresses; however, UV-B radiation can activate additional pathways not shared with other stresses.
Toll-Like Receptor 4 Protects against Lethal Leptospira interrogans Serovar Icterohaemorrhagiae Infection and Contributes to In Vivo Control of Leptospiral Burden

ABSTRACT The roles of innate immune responses in protection from or pathogenesis of severe leptospirosis remain unclear. We examined the role of Toll-like receptors (TLRs) in mouse infection and macrophage responses to Leptospira. C3H/HeJ mice (TLR4 deficient) and C3H/HeJ-SCID mice, but not C3H/OuJ mice (TLR4 intact), died after intraperitoneal infection with Leptospira interrogans serovar Icterohaemorrhagiae. Death in both C3H/HeJ mouse strains was associated with jaundice and pulmonary hemorrhage, similar to the patient from whom the isolate was obtained. In chronic sublethal infection, TLR4-deficient mice harbored more leptospires in liver, lung, and kidney than control mice. Heat-killed Leptospira stimulated macrophages to secrete proinflammatory cytokines, tumor necrosis factor alpha, interleukin-6, and macrophage inflammatory protein 2 not inhibited by polymyxin B, suggesting that leptospiral lipopolysaccharide (LPS) did not drive these responses. Anti-TLR4 and anti-MD-2 but not anti-CD14 monoclonal antibodies inhibited cytokine production. Peritoneal macrophages from CD14−/− and TLR2−/− mice exhibited no defect in cytokine responses to Leptospira compared to controls. Macrophages from C3H/HeJ, TLR4−/−, and MyD88−/− mice secreted far-lower levels of cytokines than wild-type macrophages in response to Leptospira. TLR4 plays a crucial role in protection from acute lethal infection and control of leptospiral burden during sublethal chronic infection. Cytokine responses in macrophages correlated with leptospiral clearance. These TLR4-dependent but CD14/TLR2-independent responses are likely mediated by a leptospiral ligand(s) other than LPS.
Estrogen Receptor Beta (ERβ) in Endometrial Simple Hyperplasia and Endometrioid Carcinoma

AimsThe aim of this study was to analyze the expression of estrogen receptor (ER) β in endometrioid carcinoma in comparison to non-neoplastic endometrium. MethodsFifty-seven histopathologically confirmed non-neoplastic endometria (22 proliferative phase, 15 secretory phase, and 20 simple hyperplasia without atypia), and 26 cases of endometrioid carcinoma were studied. The ERβ/ERα transcript ratio was determined by semiquantitative reverse transcription-polymerase chain reaction. The receptor protein expression was evaluated by immunohistochemistry using the Allred Scoring System. ResultsDecreased expression of ERβ, ERα, and progesterone receptor proteins was observed in endometrioid carcinoma compared with proliferative endometrium and simple hyperplasia (P<0.01, Mann-Whitney U test). Within the group of endometrioid carcinoma, a correlation of increased ERβ expression with tumors exhibiting ≥50% myoinvasion (P=0.034) was observed, whereas there was no correlation with the grade of tumor (P=0.314). There was a significant association of ERβ with ERα expression in both non-neoplastic and neoplastic endometrium indicating interdependence of expression. Progesterone receptor protein expression was influenced by ERα levels and not by ERβ as shown by regression analysis in non-neoplastic and neoplastic endometrium. ConclusionsThus, ERβ alterations are important in endometrioid carcinoma. The relationship of ERβ expression to myoinvasion warrants further investigation.
Analysis of a cone-based distributed topology control algorithm for wireless multi-hop networks

The topology of a wireless multi-hop network can be controlled by varying the transmission power at each node. In this paper, we give a detailed analysis of a cone-based distributed topology control algorithm. This algorithm, introduced in [16], does not assume that nodes have GPS information available; rather it depends only on directional information. Roughly speaking, the basic idea of the algorithm is that a node <i>u</i> transmits with the minimum power <i>p<subscrpt>u, α</subscrpt></i> required to ensure that in every cone of degree α around <i>u</i>, there is some node that <i>u</i> can reach with power <i>p<subscrpt>u, α</subscrpt></i>. We show that taking α = 5π/6 is a necessary and sufficient condition to guarantee that network connectivity is preserved. More precisely, if there is a path from <i>s</i> to <i>t</i> when every node communicates at maximum power then, if α ⪇ 5π/6, there is still a path in the smallest symmetric graph <i>G</i><subscrpt>α</subscrpt> containing all edges (<i>u, v</i>) such that <i>u</i> can communicate with <i>v</i> using power <i>p<subscrpt>u, α</subscrpt></i>. On the other hand, if α > 5π/6, connectivity is not necessarily preserved. We also propose a set of optimizations that further reduce power consumption and prove that they retain network connectivity. Dynamic reconfiguration in the presence of failures and mobility is also discussed. Simulation results are presented to demonstrate the effectiveness of the algorithm and the optimizations.
Isolation and identification of Burkholderia pseudomallei from soil using selective culture techniques and the polymerase chain reaction

An environmental soil survey to detect Burkholderia pseudomallei was performed during the dry and wet seasons in Darwin, Northern Territory, Australia. Soil was sampled at regular intervals during a 15‐month period at different depths from areas which were representative of the local, soil environment. Selective culture techniques using Ashdown's and Galimand and Dodin's methods and the polymerase chain reaction (PCR) using specific 16S rRNA primers were used to detect and identify the organism and determine its distribution within the soil stratum over the change in seasons. Results showed that Ashdown's method gave higher isolation rates in the dry season, and Galimand and Dodin's method gave higher isolation rates during the wet season. PCR of the soil enrichment proved to be a more sensitive method than culture and was also a useful confirmatory test in determining the identification of isolates where biochemical tests gave inconsistent results. The PCR primers were specific and able to detect 101 cfu g‐1 soil and 104 cfu g‐1 of soil using Ashdown's enrichment broth and Galimand and Dodin's broth, respectively. Overall the isolation of B. pseudomallei was greatest during the dry season and at the higher and lower soil depths, which is contradictory to epidemiological evidence that melioidosis occurs primarily during the wet season among patients exposed to contaminated surface soil and water.