Miracle-dz/UniFAR-FTUs huggingface dataset:
In vitro bactericidal effects of 625, 525, and 425 nm wavelength (red, green, and blue) light-emitting diode irradiation.

OBJECTIVE The purpose of this study was to evaluate the relationship of 625, 525, and 425 nm wavelengths, providing average power output and effects on three common pathogenic bacteria. BACKGROUND DATA Ultraviolet (UV) light kills bacteria, but the bactericidal effects of UV may not be unique, as 425 nm produces a similar effect. The bactericidal effects of light-emitting diode (LED) wavelengths such as 625 and 525 nm have not been described. Before conducting clinical trials, the appropriate wavelength with reasonable dose and exposure time should be established. MATERIALS AND METHODS The bactericidal effects of 625, 525, and 425 nm wavelength LED irradiation were investigated in vitro for the anaerobic bacterium Porphyromonas gingivalis and two aerobes (Staphylococcus aureus and Escherichia coli DH5α). Average power output was 6 mW/cm(2) for 1 h. The bacteria were exposed to LED irradiation for 1, 2, 4, and 8 h (21.6, 43.2, 86.4, and 172.8 J/cm(2), respectively). LED irradiation was performed during growth on agar and in broth. Control bacteria were incubated without LED irradiation. Bacterial growth was expressed in colony-forming units (CFU) and at an optical density at 600 nm in agar and broth. RESULTS The bactericidal effect of LED phototherapy depended upon wavelength, power density, bacterial viable number, and bacteria species. The bactericidal effect of 425 and 525 nm irradiation varied depending upon the bacterial inoculation, compared with unirradiated samples and samples irradiated with red light. Especially, P. gingivalis and E. coli DH5α were killed by 425 nm, and S. aureus growth was inhibited by 525 nm. However, the wavelength of 625 nm was not bactericidal for P. gingivalis, E. coli DH5α, or S. aureus. CONCLUSIONS Irradiation at 625 nm light was not bactericidal to S. aureus, E. coli, and P. gingivalis, whereas wavelengths of 425 and 525 nm had bactericidal effects. S. aureus was also killed at 525 nm.
Data Mining the Smartphone Manipulation Skills in a Coffee Farming Community: A Step for Risk Analysis

The Philippines is largely an agricultural country, and the importance of coffee in the Philippines cannot be undervalued. However, the coffee plantations are generally confronted with various insect pests and diseases. This is the reason why authorities continue to look for solutions through technological applications for coffee farming. Smartphones are becoming a functional tool in agriculture because its mobility served as an advantage to agriculture. However, challenges regarding the level of ICT, particularly of smartphones technology usage among the rural community is low due to limited knowledge and skills. Thus, this study has the primary objective to apply data mining to the smartphone manipulation skills of possible users' dataset in the province of Quirino, Philippines. Specifically, it sought to determine the optimal number of the types of potential users and to identify the different types of possible users and their skills that emerged from the clustering. The result shows that k=4 is the best choice for the dataset. The four clusters formed to represent the four groups of possible users are the good users with 25 instances, skilled users with 35 instances, the users with limited skills with 83 instances and finally, the expert users with 32 instances. Each of the groups possesses their distinct skills which emerged from the clustering technique implemented.
Fire Responses to the 2010 and 2015/2016 Amazonian Droughts

Extreme droughts in Amazonia cause anomalous increase in fire occurrence, disrupting the stability of environmental, social and economic systems. Thus, understanding how droughts affect fire patterns in this region is essential for anticipating and planning actions for remediation of possible impacts. Focused on the Brazilian Amazon biome, we investigated fire responses to the 2010 and 2015/2016 Amazonian droughts using a remote sensing data. Our results revealed that the 2015/2016 drought surpassed the 2010 drought in intensity and extent. During the 2010 drought, we found a maximum area of 846,800 km2 (24% of the Brazilian Amazon biome) with significant (p<0.05) rainfall decrease in the first trimester, while during the 2015/2016 the maximum area reached 1,702,800 km2 (47% of the Brazilian Amazon biome) in the last trimester of 2016. On the other hand, the 2010 drought had a maximum area of 840,400 km2 (23% of the Brazilian Amazon biome) with significant (p<0.05) land surface temperature increase in the first trimester, while during the 2015/2016 drought the maximum area was 2,188,800 km2 (61% of the Brazilian Amazon biome) in the last trimester of 2015. Unlike the 2010 drought, during the 2015/2016 drought, significant positive anomalies of active fire and CO2 emissions occurred mainly during the wet season, between October 2015 and March 2016. During the 2010 drought positive active fire anomalies resulted from the simultaneous increase of burned forest, non-forest vegetation and productive lands. During the 2015/2016 drought, however, this increase was dominated by burned forests. The two analysed droughts emitted together 475 Tg CO2, with 233 Tg CO2 in 2010, 147 Tg CO2 in 2015 and 95 Tg CO2 in 2016, which represented respectively 209%, 136%, 82% of the Brazil’s national targets for reducing carbon emissions from deforestation by 2020 (1288 Tg CO2 from 1996-2005 average deforestation or a rate of 0.11 Pg CO2 year-1). Finally, we anticipate that the increase of fires during the droughts showed here may intensify and can become more frequent in Amazonia due to changes in climatic variability if no regulations on fire use are implemented.
Development of explanted rat embryos in circulating medium.

The inaccessibility of rat embryos in vivo has prompted several previous attempts to grow them in culture. It has been shown that embryos explanted at head fold or early somite stages with their membranes will develop on the surface of plasma-embryo extract clots (New & Stein, 1964; New, 1966 a ) or in homologous liquid plasma or serum (Nicholas & Rudnick, 1934, 1938; Jolly & Lieure, 1938; New, 1966 a, b ). The explants can conveniently be cultured in watch glasses, as in the standard tissue culture method of Fell & Robison (1929), and development is improved if they are incubated in 60–90% O 2 and 3–5% CO 2 . Under these conditions the older embryos grow well for 30–40 h developing to 25- to 30-somite stages. However, no embryos have been observed to develop much further than this, and those explanted at stages more advanced than 30 somites have always died fairly quickly.
Simple mechanisms for subadditive buyers via duality

A central problem in mechanism design is how to design simple and approximately revenue-optimal auctions in multi-item multi-buyer settings. Prior to our work, all results only apply to cases where the buyers' valuations are linear over the items. We unify and improve all previous results, as well as generalize the results to accommodate non-linear valuations [Cai and Zhao 2017]. In particular, we prove that a simple, deterministic and Dominant Strategy Incentive Compatible (DSIC) mechanism, namely, the sequential posted price with entry fee mechanism, achieves a constant fraction of the optimal revenue among all randomized, Bayesian Incentive Compatible (BIC) mechanisms, when buyers' valuations are XOS (a superclass of submodular valuations) over independent items. If the buyers' valuations are subadditive over independent items, the approximation factor degrades to O(log m), where m is the number of items. We obtain our results by first extending the Cai-Devanur-Weinberg duality framework to derive an effective benchmark of the optimal revenue for subadditive buyers, and then developing new analytic tools that combine concentration inequality of subadditive functions, prophet-inequality type of arguments, and a novel decomposition of the benchmark.
On the evolutionary ecology of multidrug resistance in bacteria

Resistance against different antibiotics appears on the same bacterial strains more often than expected by chance, leading to high frequencies of multidrug resistance. There are multiple explanations for this observation, but these tend to be specific to subsets of antibiotics and/or bacterial species, whereas the trend is pervasive. Here, we consider the question in terms of strain ecology: explaining why resistance to different antibiotics is often seen on the same strain requires an understanding of the competition between strains with different resistance profiles. This work builds on models originally proposed to explain another aspect of strain competition: the stable coexistence of antibiotic sensitivity and resistance observed in a number of bacterial species. We first identify a partial structural similarity in these models: either strain or host population structure stratifies the pathogen population into evolutionarily independent sub-populations and introduces variation in the fitness effect of resistance between these sub-populations, thus creating niches for sensitivity and resistance. We then generalise this unified underlying model to multidrug resistance and show that models with this structure predict high levels of association between resistance to different drugs and high multidrug resistance frequencies. We test predictions from this model in six bacterial datasets and find them to be qualitatively consistent with observed trends. The higher than expected frequencies of multidrug resistance are often interpreted as evidence that these strains are out-competing strains with lower resistance multiplicity. Our work provides an alternative explanation that is compatible with long-term stability in resistance frequencies.
Identification of the Minimal Phosphoacceptor Site Required for in Vivo Activation of Interferon Regulatory Factor 3 in Response to Virus and Double-stranded RNA*

The ubiquitously expressed latent interferon regulatory factor (IRF) 3 transcription factor is activated in response to virus infection by phosphorylation events that target a cluster of Ser/Thr residues,382GGASSLENTVDLHISNSHPLSLTSDQY408at the C-terminal end of the protein. To delineate the minimal phosphoacceptor sites required for IRF-3 activation, several point mutations were generated and tested for transactivation potential and cAMP-response element-binding protein-binding protein/p300 coactivator association. Expression of the IRF-3 S396D mutant alone was sufficient to induce type I IFN β, IFNα1, RANTES, and the interferon-stimulated gene 561 promoters. Using SDS-PAGE and immunoblotting with a novel phosphospecific antibody, we show for the first time that, in vivo, IRF-3 is phosphorylated on Ser396 following Sendai virus infection, expression of viral nucleocapsid, and double-stranded RNA treatment. These results demonstrate that Ser396 within the C-terminal Ser/Thr cluster is targeted in vivo for phosphorylation following virus infection and plays an essential role in IRF-3 activation. The inability of the phosphospecific antibody to detect Ser396phosphorylation in lipopolysaccharide-treated cells suggests that other major pathways may be involved in IRF-3 activation following Toll-like receptor 4 stimulation.
VERSE: Bridging Screen Readers and Voice Assistants for Enhanced Eyes-Free Web Search

People with visual impairments often rely on screen readers when interacting with computer systems. Increasingly, these individuals also make extensive use of voice-based virtual assistants (VAs). We conducted a survey of 53 people who are legally blind to identify the strengths and weaknesses of both technologies, and the unmet opportunities at their intersection. We learned that virtual assistants are convenient and accessible, but lack the ability to deeply engage with content (e.g., read beyond the first few sentences of an article), and the ability to get a quick overview of the landscape (e.g., list alternative search results and suggestions). In contrast, screen readers allow for deep engagement with content (when content is accessible), and provide fine-grained navigation and control, but at the cost of reduced walk-up-and-use convenience. Based on these findings, we implemented VERSE (Voice Exploration, Retrieval, and SEarch), a prototype that extends a VA with screen-reader-inspired capabilities, and allows other devices (e.g., smartwatches) to serve as optional input accelerators. In a usability study with 12 blind screen reader users we found that VERSE meaningfully extended VA functionality. Participants especially valued having access to multiple search results and search verticals.
Relative age effects in international age group championships: A study of Spanish track and field athletes

The relative age effect is a well-researched phenomenon, however there is still a dearth of understanding in track and field and female sport. This study investigated the role of relative age on selection for international competition of Spanish age group athletes between 2006–2014. Six hundred and forty two athletes competed for Spain at U20 or U18 age group international competition (n = 359 males; 283 females) across 9 years. The birthdates of these athletes were compared against the population of registered athletes at that time (14,502 males; 10,096 females). The results highlighted the influential role of relative age on selection to these opportunities. In line with previous research, this effect was mediated by age and gender, with stronger effects for both males and younger athletes (U18). The data best supported the ‘maturation-selection’ hypothesis as a mechanism for RAEs. These results highlight the need to carefully consider the role and need for international competitive opportunities at different age groups. A number of possible context relevant solutions are discussed, including correction adjustments techniques and competition structure within track and field.
Highly Scalable Near Memory Processing with Migrating Threads on the Emu System Architecture

There is growing evidence that current architectures do not well handle cache-unfriendly applications such as sparse math operations, data analytics, and graph algorithms. This is due, in part, to the irregular memory access patterns demonstrated by these applications, and in how remote memory accesses are handled. This paper introduces a new, highly-scalable PGAS memory-centric system architecture where migrating threads travel to the data they access. Scaling both memory capacities and the number of cores can be largely invisible to the programmer.The first implementation of this architecture, implemented with FPGAs, is discussed in detail. A comparison of key parameters with a variety of today's systems, of differing architectures, indicates the potential advantages. Early projections of performance against several well-documented kernels translate these advantages into comparative numbers. Future implementations of this architecture may expand the performance advantages by the application of current state of the art silicon technology.
Trends in prevalence, incidence and mortality of diagnosed and silent coronary heart disease in Quebec.

INTRODUCTION Of all cardiovascular causes of mortality, coronary heart disease (CHD) remains the leading cause of death. Our objectives were to establish trends in the prevalence and incidence of CHD in the province of Quebec, and to determine the proportion of CHD mortality that had no previous CHD diagnosis. METHODS Trends in prevalence, incidence and mortality were examined with a population-based study using the Quebec Integrated Chronic Disease Surveillance System, which links several health administrative databases. Data are presented using two case definitions for Quebecers aged 20 years and over: 1) a validated definition, and 2) CHD causes of death codes added to estimate the proportion of deaths that occurred without any previous CHD diagnosis as a proxy for sudden cardiac death (SCD). RESULTS In 2012/2013, the crude prevalence of CHD was 9.4% with the first definition (593 000 people). Between 2000/2001 and 2012/2013, the age-standardized prevalence increased by 14%, although it has been decreasing slightly since 2009/2010. Age-standardized incidence and mortality rates decreased by 46% and 26% respectively, and represented a crude rate of 6.9 per 1000 and 5.2% in 2012/2013. The proportion identified only by CHD mortality, our SCD proxy, was only significant for the incident cases (0.38 per 1000 in 2009/2010) and declined over the study period. CONCLUSION The prevalence of CHD has tended to decrease in recent years, and incidence and mortality have been declining in Quebec. Most CHD mortality occurs in previously diagnosed patients and only a small proportion of incident cases were not previously identified.
Endovascular Recanalization of Non-acute Symptomatic Middle Cerebral Artery Total Occlusion and Its Short-Term Outcomes

Background and Purpose: The optimal treatment for patients with non-acute symptomatic middle cerebral artery (MCA) total occlusion and a high risk of recurrent ischemic stroke despite medical management is not well-established. We aimed to assess the feasibility, safety, and short-term outcomes of angioplasty and stenting for these patients. Methods: Data of 22 patients with non-acute symptomatic MCA total occlusion who have failed medical management and undergone endovascular recanalization were retrospectively collected in our prospective database. All occlusive lesions were predilated with conventional balloons, followed by paclitaxel-coated coronary balloon inflation or not, and then a remedial stenting was performed or not, depending on the discretion of the operator. The rate of successful recanalization, perioperative outcomes, and short-term outcomes, such as restenosis and stroke recurrence, was analyzed. Results: Successful recanalization was achieved in 95.5% of patients, with 14 patients undergoing balloon angioplasty and 7 patients undergoing remedial stenting. Seven patients developed perioperative complications, including one patient with persistent neurological deficit. Over a median clinical follow-up duration of 5.0 months, only one patient had recurrent ischemic symptoms attributed to the cessation of antiplatelet treatment owing to postoperative intracranial hemorrhage. The proportion of patients who achieved favorable clinical outcome (modified ranking scale score of 0–2) was 85.7%. Post-procedural repeat vascular imaging was performed at 4.5 ± 1.84 months, with nine and one patient undergoing cerebral angiography and magnetic resonance angiography, respectively. One (10%) artery presented with asymptomatic reocclusion. Conclusions: Angioplasty and stenting may be feasible for the patients with non-acute symptomatic atherosclerotic MCA total occlusive disease who have failed medical management.
Changes of mucosal immunity and antioxidation activity in elite male Taiwanese taekwondo athletes associated with intensive training and rapid weight loss

Objective The aim of this study was to investigate the cumulative effects of prolonged, intensive training and rapid weight loss on immunological parameters and antioxidation activity of elite male Taiwanese taekwondo athletes. Design 16 Elite male taekwondo athletes (mean age, 21.6 (1.3) years; mean height, 173.7 (5.5) cm) volunteered to participate in this study. Beginning at 30 days before a national competition, saliva samples were obtained during a 7-week training, the competition and the postcompetition period. Levels of salivary IgA, cortisol, lactoferrin and free-radical scavenging activity were measured at 30-, 14-, 7- and 1-day precompetition and 1-, 7- and 19-day postcompetition. Body weight and body fat were also recorded. Results The mean body weight was notably decreased during the week immediately before the competition. Results reveal that the levels of salivary IgA were differentially regulated during the training, competition and recovery period, while the salivary cortisol and lactoferrin concentrations and free-radical scavenging activity were not appreciably affected during the training and the competition period. Furthermore, the results of an upper respiratory tract infection incidence indicate that following the decreases of mucosal immunity, the risk of acquiring infection was significantly increased. Conclusions Our results demonstrated that mucosal immunity in elite male taekwondo athletes is modulated by exercise and rapid weight reduction during the training, competition and recovery period. Cumulative effects of prolonged intensive training and rapid weight reduction suppressed mucosal immunity. Furthermore, because of the “open window” of impaired immunity during the precompetition period, the incidence of upper respiratory tract infection was significantly increased after the competition.
Impact of the Food Additive Titanium Dioxide (E171) on Gut Microbiota-Host Interaction

The interaction between gut microbiota and host plays a central role in health. Dysbiosis, detrimental changes in gut microbiota and inflammation have been reported in non-communicable diseases. While diet has a profound impact on gut microbiota composition and function, the role of food additives such as titanium dioxide (TiO2), prevalent in processed food, is less established. In this project, we investigated the impact of food grade TiO2 on gut microbiota of mice when orally administered via drinking water. While TiO2 had minimal impact on the composition of the microbiota in the small intestine and colon, we found that TiO2 treatment could alter the release of bacterial metabolites in vivo and affect the spatial distribution of commensal bacteria in vitro by promoting biofilm formation. We also found reduced expression of the colonic mucin 2 gene, a key component of the intestinal mucus layer, and increased expression of the beta defensin gene, indicating that TiO2 significantly impacts gut homeostasis. These changes were associated with colonic inflammation, as shown by decreased crypt length, infiltration of CD8+ T cells, increased macrophages as well as increased expression of inflammatory cytokines. These findings collectively show that TiO2 is not inert, but rather impairs gut homeostasis which may in turn prime the host for disease development.
Factors affecting the Social Networks Acceptance: An Empirical Study using PLS-SEM Approach

There is an increase in the number of studies being carried out on the acceptance of social media applications. Nonetheless, the identification of the factors affecting its acceptance in educational purposes is still neglected. Hence, the objective of this study is to develop a conceptual model through the extension of the Technology Acceptance Model (TAM) with perceived playfulness to measure the students' acceptance of social networks in education. A total of 320 valid questionnaire surveys were collected from the students enrolled at University of Fujairah in the United Arab of Emirates (UAE). The partial least squares-structural equation modeling (PLS-SEM) approach was used to analyze the collected data. The empirical results indicated that perceived playfulness, perceived usefulness, and perceived ease of use are significant indicators of students' intention to use social networks in education.