Miracle-dz/UniFAR-FTUs huggingface dataset:
Mindfulness in nursing: an evolutionary concept analysis.

AIM To report an analysis of the concept of mindfulness. BACKGROUND Mindfulness is an emerging concept in health care that has significant implications for a variety of clinical populations. Nursing uses this concept in limited ways, and subsequently requires conceptual clarity to further identify its significance, use and applications in nursing. DESIGN Mindfulness was explored using Rodgers evolutionary method of concept analysis. DATA SOURCES For this analysis, a sample of 59 English theoretical and research-based articles from the Cumulative Index to Nursing and Allied Health Literature database were obtained. The search was conducted between all-inclusive years of the database, 1981-2012. REVIEW METHODS Data were analysed with particular focus on the attributes, antecedents, consequences, references and related terms that arose in relation to mindfulness in the nursing literature. RESULTS The analysis found five intricately connected attributes: mindfulness is a transformative process where one develops an increasing ability to 'experience being present', with 'acceptance', 'attention' and 'awareness'. Antecedents, attributes and consequences appeared to inform and strengthen one another over time. Mindfulness is a significant concept for the discipline of nursing with practical applications for nurse well-being, the development and sustainability of therapeutic nursing qualities and holistic health promotion. CONCLUSION It is imperative that nurse well-being and self-care become a more prominent focus in nursing research and education. Further development of the concept of mindfulness could support this focus, particularly through rigorous qualitative methodologies.
Depression following critical illness: Analysis of incidence and risk factors

Purpose Depression is common in ICU survivors and is known to negatively affect health-related quality of life. The reported risk factors for depression include increasing age, gender and hospital and ICU length of stay. The aim of this study was to investigate the risk factors for depression in survivors of critical illness. Materials and methods Patients attending the ICU Follow-up Clinic completed the Hospital Anxiety and Depression Scale and data were also collected from their medical records. Risk factors investigated included age, gender, Apache II score, ICU length of stay and a diagnosis of sepsis during ICU admission. Results A total of 63 patients participated, with 29 (46%) patients suffering with depression. On multivariable logistic regression, the only significant risk factor for depression was sepsis (p < 0.05, odds ratio: 6.8; 95% CI: 1.8–25.8). Age, gender and ICU length of stay were not found to be risk factors for depression. Conclusions There are a number of potential causative factors as to why sepsis would cause long-term depression and this needs further investigation.
Using Bloom’s Taxonomy to Gauge Students’ Reading Comprehension Performance

Assessment is an essential part of the teaching-learning process. Students’ learning can be measured by different procedures. Despite a significant increase in test procedures, numerous issues surrounding testing of comprehension remain unresolved. This paper investigates the relationship between the level of thinking processes in comprehension questions and the students` performance. The findings indicate that the level of questions designed according to Bloom’s Taxonomy influence the students’ performance in answering comprehension questions. The findings conclude that there’s a relationship between the level of thinking processes needed and the students’ ability to answer these questions correctly. This paper provides a common base for further discussionsont the undergraduates’ competence in English Language as well as the recommendations on the techniques that could be used to handle higher order level questions. Keywords: Level of thinking process; Reading Comprehension Questions; Performance; Bloom’s Taxonomy; Multiple choice questions (MCQs) Resume: L'evaluation est une partie essentielle du processus de l'enseignement-apprentissage. L'apprentissage des eleves peut etre mesure par des procedures differentes. Malgre un accroissement significatif dans les procedures de test, de nombreuses questions concernant les tests de comprehension restent non resolues. Cet article etudie la relation entre le niveau des processus de pensee dans les questions de comprehension et de la performance des etudiants. Les resultats indiquent que le niveau de questions concues selon la taxonomie de Bloom influence sur la performance des eleves dans leurs reponses aux questions de comprehension. Les resultats concluent qu'il y a une relation entre le niveau de processus de pensee necessaire et la capacite des eleves a repondre a ces questions correctement. Ce document fournit une base commune pour des discussions plus approfondies sur la competence de l'anglais des eleves de premier cycle, ainsi que les recommandations sur les techniques qui pourraient etre utilisees pour traiter des questions d'un plus haut niveau.Mots-cles: niveau de processus de pensees; questions sur la comprehension ecrite; performance; taxonomie de Bloom; questions de choix multiple (MCQs)
U-HO1, a new cell line derived from a primary refractory classical Hodgkin lymphoma

The Hodgkin cell line U-HO1 was established from a malignant pleural effusion of a 23-year-old male patient during the end stage of refractory nodular sclerosing classical Hodgkin lymphoma (cHL). Since its establishment in 2005, U-HO1 has maintained stable characteristics in vitro and has a doubling time of about 4 days under standard culture conditions. U-HO1 forms typical Reed-Sternberg cells in suspension, is EBV negative, lacks HLA-A, -B, -C but expresses HLA-D proteins/CD74 and exposes CD15 together with CD30 in the absence of CD19 and CD20 on the cell surface. Karyotype analysis of U-HO1 revealed a hyperdiploid karyotype with multiple clonal aberrations. Most significant is an elongated chromosome 2, der(2)t(2;10)(q35; q16.1)add(2)(p13). CGH analysis revealed the following imbalances: ish cgh dim(1)(p13p31)(p12q21), enh(2)(p13p23), dim(4)(q31.3qter), enh(6)(q22q27), enh(12), enh(18), enh(20) (q13.1pter). FISH analysis showed about six-fold amplification of REL and BCL11A, thus, U-HO1 is prototypical for cHL in every aspect tested so far. As an outstanding feature compared to the existing HL cell lines, U-HO1 has high levels of microRNA transcripts of MIRN216 and MIRN217 located in the amplicon 2p16. Compared to other HL cell lines, U-HO1 proved far less genetically aberrant suggesting that U-HO1’s imbalances suffice to cause the full-blown phenotype of primary refractory cHL.
EVOLUTIONARY CONSTRAINT AND ECOLOGICAL CONSEQUENCES

One of the most important shifts in evolutionary biology in the past 50 years is an increased recognition of sluggish evolution and failures to adapt, which seem paradoxical in view of abundant genetic variation and many instances of rapid local adaptation. I review hypotheses of evolutionary constraint (or restraint), and suggest that although constraints on individual characters or character complexes may often reside in the structure or paucity of genetic variation, organism‐wide stasis, as described by paleontologists, might better be explained by a hypothesis of ephemeral divergence, according to which the spatial or temporal divergence of populations is often short‐lived because of interbreeding with nondivergent populations. Among the many consequences of acknowledging evolutionary constraints, community ecology is being transformed as it takes into account phylogenetic niche conservatism and the strong imprint of deep history.
Adult clients' recall of oral health education services received in private practice.

PURPOSE The purpose of this study was to determine adult clients' recall of oral health education services they received in private practice settings. METHODS A written questionnaire was completed by a convenience sample of 199 adult clients who each had an appointment at a university dental hygiene clinic. Responses were statistically analyzed to generate frequency distributions of recall of oral health education services received in private practice and to determine if statistical differences existed in the number of services recalled according to selected client characteristics. RESULTS The results indicated that 14 of the 22 oral health education services included on the questionnaire were reported to have been provided to fewer than half of the study participants when they were treated in their private dental care setting. The subjects were most likely to recall they were given a toothbrush. Chi-square analysis of selected client characteristic variables indicated that only four of the services were statistically significant between the reported frequencies and client age and periodontal health status. The differences between the reported frequency of services for females and males were not statistically significant. Subjects recalled that more oral health education services had been provided in conjunction with a prophylaxis by a dental hygienist; the differences in the reported frequencies for 16 of the 22 services were statistically significant. (p < or = .05) CONCLUSIONS The convenience sample and data constraints, which depended on the clients' recall of services received in a private practice setting, must be considered in interpreting the results. Even though dental hygienists provide more oral health education services than other oral healthcare practitioners, the generally low frequencies of adult client recall of oral health education services received in private practice settings indicate that oral healthcare providers may not incorporate effective learning strategies into their health education programs.
Mechanisms by Which the G333D Mutation in Human Immunodeficiency Virus Type 1 Reverse Transcriptase Facilitates Dual Resistance to Zidovudine and Lamivudine

ABSTRACT Recent studies have identified a role for mutations in the connection and RNase H domains of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) resistance to nucleoside analog RT inhibitors (NRTI). To provide insight into the biochemical mechanism(s) involved, we investigated the effect of the G333D mutation in the connection domain of RT on resistance to zidovudine (AZT) and lamivudine (3TC) in enzymes that contain both M184V and thymidine analog mutations (TAMs; M41L, L210W, and T215Y). Our results from steady-state kinetic, pre-steady-state kinetic, and thermodynamic analyses indicate that G333D facilitates dual resistance to AZT and 3TC in two ways. First, in combination with M184V, G333D increased the ability of HIV-1 RT to effectively discriminate between the normal substrate dCTP and 3TC-triphosphate. Second, G333D enhanced the ability of RT containing TAMs and M184V to bind template/primer terminated by AZT-monophosphate (AZT-MP), thereby restoring ATP-mediated excision of AZT-MP under steady-state assay conditions. This study is the first to elucidate a molecular mechanism whereby a mutation in the connection domain of RT can affect NRTI susceptibility at the enzyme level.
Should I just listen to you or change your mind too? Target's perceived efficacy of agents’ interpersonal affect improvement strategies

People shape and influence others' emotions every day. If these attempts are perceived as successful, they may have a positive effect on people's relationships and well-being. Across two studies, targets' perceived efficacy of regulation strategies to improve their sadness and anxiety/stress has been investigated. In Study 1, participants (n = 120) were provided with two scenarios depicting sadness and anxiety/stress and asked to imagine themselves in these situations. Afterwards, they were provided with different regulation strategies and asked to rate their perceived efficacy to downregulate their sadness and anxiety. In Study 2, participants (n = 120) were asked to describe a situation where they felt sad and another one where they felt anxious. They were then provided with strategies aimed at reducing their sadness and anxiety. Results from both studies showed that whereas for sadness higher perceived efficacy was predicted by affective engagement, for anxiety/stress was predicted by cognitive engagement.
Cellular/molecular Mechanisms Underlying Developmental Speeding in Ampa-epsc Decay Time at the Calyx of Held

The time course of synaptic conductance is important in temporal precision of information processing in the neuronal network. The AMPA receptor (AMPAR)-mediated EPSCs at the calyx of Held become faster in decay time as animals mature. To clarify how desensi-tization and deactivation of AMPARs contribute to developmental speeding of EPSCs, we compared the decay time of quantal EPSCs (qEPSCs) with the deactivation and desensitization times of AMPAR currents induced in excised patches by fast glutamate application (AMPA patch currents). Both the deactivation and desensitization times of AMPA patch currents became markedly faster from postnatal day 7 (P7) to P14 and changed little thereafter. In individual neurons, throughout development (P7–P21), the time constants of deacti-vation and fast desensitization in AMPA patch currents were similar to each other and close to the qEPSC decay time constant. Cyclothia-zide (CTZ) abolished the fast desensitization, prolonged deactivation of AMPA patch currents, and slowed the decay time of EPSCs. The effects of CTZ on AMPA patch currents were unchanged throughout development, whereas its effect on EPSCs became weaker as animals matured. In single-cell reverse transcription-PCR analysis, glutamate receptor subunit 4 (GluR4) flop increased from P7 to P14 and changed little thereafter. At P7, the GluR4 flop abundance had an inverse correlation with the qEPSC decay time. These results together suggest that both desensitization and deactivation of AMPARs are involved in the EPSC decay time, but the contribution of desensitiza-tion decreases during postnatal development at the calyx of Held.
The Pharmacologic and Clinical Effects of Medical Cannabis

Cannabis, or marijuana, has been used for medicinal purposes for many years. Several types of cannabinoid medicines are available in the United States and Canada. Dronabinol (schedule III), nabilone (schedule II), and nabiximols (not U.S. Food and Drug Administration approved) are cannabis‐derived pharmaceuticals. Medical cannabis or medical marijuana, a leafy plant cultivated for the production of its leaves and flowering tops, is a schedule I drug, but patients obtain it through cannabis dispensaries and statewide programs. The effect that cannabinoid compounds have on the cannabinoid receptors (CB1 and CB2) found in the brain can create varying pharmacologic responses based on formulation and patient characteristics. The cannabinoid Δ9‐tetrahydrocannabinol has been determined to have the primary psychoactive effects; the effects of several other key cannabinoid compounds have yet to be fully elucidated. Dronabinol and nabilone are indicated for the treatment of nausea and vomiting associated with cancer chemotherapy and of anorexia associated with weight loss in patients with acquired immune deficiency syndrome. However, pain and muscle spasms are the most common reasons that medical cannabis is being recommended. Studies of medical cannabis show significant improvement in various types of pain and muscle spasticity. Reported adverse effects are typically not serious, with the most common being dizziness. Safety concerns regarding cannabis include the increased risk of developing schizophrenia with adolescent use, impairments in memory and cognition, accidental pediatric ingestions, and lack of safety packaging for medical cannabis formulations. This article will describe the pharmacology of cannabis, effects of various dosage formulations, therapeutics benefits and risks of cannabis for pain and muscle spasm, and safety concerns of medical cannabis use.
Time Perception and Retirement Saving: Lessons from Behavioral Decision Research

This chapter provides a behavioral decision perspective on the implications of intertemporal choice research for retirement savings. In particular, we focus on two cognitive mechanisms explaining how and why future monetary outcomes are discounted: (1) changes in the perception of delayed outcomes due to changes in mental representations and perceived slack, and (2) changes in the perception of temporal distance to delayed outcomes. Relevant recent findings are reviewed and the implications for retirement savings are discussed.
Leveraging Customer Involvement for Fueling Innovation: The Role of Relational and Analytical Information Processing Capabilities

How do IT-enabled capabilities influence the ability of firms to leverage customer involvement to shape amount of innovation? This study argues and theorizes that effective processing and management of customer information flows requires that organizations possess what we call as relational information processing capability (RIPC) and analytical information processing capability (AIPC). Drawing on and extending the theories of absorptive capacity and complementarities in the context of innovation, we posit that RIPC and AIPC complement product-focused customer involvement and information-intensive customer involvement practices respectively to enhance the amount of firm innovation. To test our hypotheses, we collected archival data from more than 300 large U.S. manufacturing firms and map the relational and analytical information processing capabilities to specific IT applications. Consistent with our theorizing, we find that RIPC positively moderates the relationship between product-focused customer involvement and amount of firm innovation; and AIPC positively moderates the relationship between information-intensive customer involvement and amount of firm innovation. In further exploratory analysis, we find a positive three-way interaction between AIPC, RIPC, and product-focused customer involvement. Taken together, our results suggest that configurations of IT-enabled capabilities alone are not enough for innovation; instead firms benefit more when specific configurations of IT-enabled capabilities are leveraged in unison with specific types of customer involvement. The study contributes to theory and practice by shedding light on important complementarities between specific types of customer involvement (product-focused customer involvement and information-intensive customer involvement) and specific IT-enabled capabilities (relational information processing capability and analytical information processing capability).
A study of math anxiety in developmental courses in a Texas community college

The purpose of this study was three fold 1) to investigate the effects of math anxiety with respect to its impact on developmental students in a community college, 2) to determine if math anxiety could significantly reduced in one semester and 3) to determine if addressing anxiety issues and pedagogical practices would result in students having a more positive attitudinal perspective towards math. The final purpose was to determine if math anxiety was a significant variable contributing to math deficiencies among developmental students. A mixed methods design was most effective to quantitatively capture the results of a comparative experimental design and qualitatively capture the experience of the student. In the quantitative section of this study, a pre-test/posttest design was utilized to measure and compare math anxiety reduction ix (dependent variable). The study consisted of a pre-test measuring math anxiety levels and attitudes towards math at the beginning of the semester. A parallel form was given at the end of the semester. There was a comparison (control) group and a treatment (experimental) group for the purposes of comparing data. The researcher delivered an intervention in the form of a presentation to address math anxiety issues. In this presentation she provided cognitive-behavioral techniques aimed at reducing math anxiety. Post-test scores were then compared to pre-test scores to determine if there were any significant changes in the math anxiety variable. The overall findings of the study revealed the treatment group did not have a significant reduction in anxiety scores. However, the researcher found math anxiety scores to be higher among college algebra students. Thus, the overall effect of the intervention served as an inhibitor to math anxiety when scores were compared between the treatment and control groups.
Dynamic shape capture using multi-view photometric stereo

We describe a system for high-resolution capture of moving 3D geometry, beginning with dynamic normal maps from multiple views. The normal maps are captured using active shape-from-shading (photometric stereo), with a large lighting dome providing a series of novel spherical lighting configurations. To compensate for low-frequency deformation, we perform multi-view matching and thin-plate spline deformation on the initial surfaces obtained by integrating the normal maps. Next, the corrected meshes are merged into a single mesh using a volumetric method. The final output is a set of meshes, which were impossible to produce with previous methods. The meshes exhibit details on the order of a few millimeters, and represent the performance over human-size working volumes at a temporal resolution of 60Hz.
AD Award Number : DAMD 17-001-0314 TITLE : Radiation-Induced Chemosensitization : Pbtentiation of Antitumor Activity of Polymer-Drug Conjugates

s: Li, C, Ke, Milas, L. , Chamsangavej, C, and Wallace S. Sensitization of macromolecular chemotehrapy: modulation of EPR effect by radiation. 27* International Symposium on Controlled Release of Bioactive Materials, Paris, France, July 7-13,2000. Ke, S. , Chamsagavei, C, Wallace, S. , Li, C. Elevated Semm VEGF level as a prognostic marker in combined PG-TXL (CT-2103) and radiation therapy in mice with murine ovarian OCA-1 tumor, 92nd American Association for Cancer Research Annual Meeting March 24-28, New Orleans, LA, 2001. List of Personnel Received Pay from the Research EfFort Xiaoxia Wen, MS, Senior Research Assistant Shi Ke, MD, Instractor
What constitutes a prescribing error in paediatrics?

Objective: To develop a practitioner led definition of a prescribing error for use in prevalence/incidence studies in paediatric practice. Design: A two stage Delphi technique was used to obtain the views of a panel of expert health professionals working in the hospital paediatric setting. The extent of their agreement on a definition of a prescribing error, and on 40 scenarios that might be classified as prescribing errors in paediatric practice, was obtained. Results: Response rates were 84% (n = 42) in the first Delphi round and 95% (n = 40) in the second. Consensus was to accept the general definition of a prescribing error. In addition, there was consensus that 27 of the 40 scenarios should be included as prescribing errors, 10 should be excluded, and three may be considered prescribing errors depending on the individual clinical situation. Failure to communicate essential information, transcription errors and the use of drugs, formulations, or doses inappropriate for the individual patient were considered prescribing errors. Deviations from policies or guidelines, use of unlicensed and off-label drugs, and omission of non-essential information were not considered prescribing errors. Conclusion: A general definition of a prescribing error has been developed that is applicable to the paediatric setting, together with more detailed guidance regarding the types of events that should be included. These findings are suitable for use in future research into the incidence and nature of prescribing errors in paediatrics.