Miracle-dz/UniFAR-FTUs huggingface dataset:
Cost-effectiveness of adjuvant systemic therapy in low-risk breast cancer patients with nodal isolated tumor cells or micrometastases.

BACKGROUND The cost-effectiveness of adjuvant systemic therapy in patients with low-risk breast cancer and nodal isolated tumor cells or micrometastases is unknown. PATIENTS AND METHODS A cost-effectiveness analysis of adjuvant systemic therapy was carried out using the costs per 1% event prevented after 5 years of follow-up as incremental cost-effectiveness ratio (ICER). Secondary objective was to establish when adjuvant systemic therapy becomes cost saving. Patients included in the MIRROR study with isolated tumor cells or micrometastases who had a complete 5-year follow-up and who either did or did not receive systemic therapy were eligible. Sensitivity analyses were carried out. RESULTS In the no adjuvant therapy cohort (N = 366), 24.9% of patients had an event within 5 years versus 16.8% of patients in the adjuvant therapy cohort (N = 483) (P < 0.01). The ICER was €363 per 1% event prevented. Beyond 18 years after diagnosis, the extrapolated mean cumulative costs per patient in the no adjuvant therapy cohort exceeded those of the adjuvant therapy cohort. CONCLUSIONS In this population of breast cancer patients with isolated tumor cells or micrometastases, €36 300 had to be invested to prevent one event in 5 years of follow-up. Adjuvant systemic therapy was cost saving beyond 18 years after diagnosis.
Grain and food quality traits in some aromatic long and short grain rice varieties of India

Ten aromatic long and short grained rice varieties were evaluated for physico-chemical and proximate analysis to find out better varieties. It was revealed that high head rice recovery was observed in Kalajira (68.0%). Kernel length was highest in Pusa sugandh-2 (7.6 mm) and lowest in Kalajira (4.3 mm). Kernel breadth ranged from 1.72 (Pusa basmati-1) to 2.18 mm(Kalajira). Kernel length after cooking (KLAC) ranged from 7.33 (Tulsiphool) to 13.3 mm (Pusa basmati-1). Amylose content varied from 16.8 (CRM-839) to 25.05% (Geetanjali). Protein content was lowest in Dubraj (7.2%) and highest in Tarori basmati (8.96%). Carbohydrate content ranged from 64.6 (Pusa sugandh-2) to 89.15% (Kalanamak). The basmati varieties had more fat than the mean value whereas the aromatic short grained had low fat content. The sugar content varied from 0.54 (Kalanamak) to 0.87% (Pusabasmati-1). Low iron content was reported in Pusa sugandh-2 (7.09 mg/kg) and highest iron in Kalanamak (19.16 mg/kg). Zinc content ranged from 14.33 (Ketekijoha) to 32.04 mg/kg (Pusa sugandh-2).
Can Particulate Air Sampling Predict Microbial Load in Operating Theatres for Arthroplasty?

Several studies have proposed that the microbiological quality of the air in operating theatres be indirectly evaluated by means of particle counting, a technique derived from industrial clean-room technology standards, using airborne particle concentration as an index of microbial contamination. However, the relationship between particle counting and microbiological sampling has rarely been evaluated and demonstrated in operating theatres. The aim of the present study was to determine whether particle counting could predict microbiological contamination of the air in an operating theatre during 95 surgical arthroplasty procedures. This investigation was carried out over a period of three months in 2010 in an orthopedic operating theatre devoted exclusively to prosthetic surgery. During each procedure, the bacterial contamination of the air was determined by means of active sampling; at the same time, airborne particulate contamination was assessed throughout the entire procedure. On considering the total number of surgical operations, the mean value of the total bacterial load in the center of the operating theatre proved to be 35 CFU/m3; the mean particle count was 4,194,569 no./m3 for particles of diameter ≥0.5 µm and 13,519 no./m3 for particles of diameter ≥5 µm. No significant differences emerged between the median values of the airborne microbial load recorded during the two types of procedure monitored. Particulates with a diameter of ≥0.5 µm were detected in statistically higher concentrations (p<0.001) during knee-replacement procedures. By contrast, particulates with a diameter of ≥5 µm displayed a statistically higher concentration during hip-replacement procedures (p<0.05). The results did not reveal any statistically significant correlation between microbial loads and particle counts for either of the particle diameters considered (≥0.5 µm and ≥5 µm). Consequently, microbiological monitoring remains the most suitable method of evaluating the quality of air in operating theatres.
Gut microbiota of humans, dogs and cats: current knowledge and future opportunities and challenges

High-throughput DNA sequencing techniques allow for the identification and characterisation of microbes and their genes (microbiome). Using these new techniques, microbial populations in several niches of the human body, including the oral and nasal cavities, skin, urogenital tract and gastrointestinal tract, have been described recently. Very little data on the microbiome of companion animals exist, and most of the data have been derived from the analysis of the faeces of healthy laboratory animals. High-throughput assays provide opportunities to study the complex and dense populations of the gut microbiota, including bacteria, archaea, fungi, protozoa and viruses. Our laboratory and others have recently described the predominant microbial taxa and genes of healthy dogs and cats and how these respond to dietary interventions. In general, faecal microbial phylogeny (e.g. predominance of Firmicutes, Bacteroidetes, Proteobacteria and Actinobacteria) and functional capacity (e.g. major functional groups related to carbohydrate, protein, DNA and vitamin metabolism; virulence factors; and cell wall and capsule) of the canine and feline gut are similar to those of the human gut. Initial sequencing projects have provided a glimpse of the microbial super-organism that exists within the canine and feline gut, but leaves much to be explored and discovered. As DNA provides information only about potential functions, studies that focus on the microbial transcriptome, metabolite profiles, and how microbiome changes affect host physiology and health are clearly required. Future studies must determine how diet composition, antibiotics and other drug therapies, breed and disease affect or are affected by the gut microbiome and how this information may be used to improve diets, identify disease biomarkers and develop targeted disease therapies.
Inferior alveolar nerve damage following removal of mandibular third molar teeth.

Due to anatomical location, it is possible to traumatize inferior alveolar nerve. Inferior Alveolar Nerve (IAN) injury is a serious neurological complication which can result from a number of reasons, the most common of which is by performing oral and maxillofacial surgical procedures. These nerves can be damaged as the result of direct or indirect forces. Despite these complications, the removal of third molars associated with disease is generally justified. The purpose of this paper is to identify the incidence of IAN damage following the removal of mandibular third molar teeth.
Antioxidant Treatment Regulates the Humoral Immune Response during Acute Viral Infection

ABSTRACT Generation of reactive oxygen intermediates (ROI) following antigen receptor ligation is critical to promote cellular responses. However, the effect of antioxidant treatment on humoral immunity during a viral infection was unknown. Mice were infected with lymphocytic choriomeningitis virus (LCMV) and treated with Mn(III)tetrakis(4-benzoic acid)porphyrin chloride (MnTBAP), a superoxide dismutase mimetic, from days 0 to 8 postinfection. On day 8, at the peak of the splenic response in vehicle-treated mice, virus-specific IgM and IgG antibody-secreting cells (ASC) were decreased 22- and 457-fold in MnTBAP-treated animals. By day 38, LCMV-specific IgG ASC were decreased 5-fold in the bone marrow of drug-treated mice, and virus-specific antibodies were of lower affinity. Interestingly, antioxidant treatment had no effect on the number of LCMV-specific IgG memory B cells. In addition to decreases in ASC, MnTBAP treatment decreased the number of functional virus-specific CD4+ T cells. The decreased numbers of ASC observed on day 8 in drug-treated mice were due to a combination of Bim-mediated cell death and decreased proliferation. Together, these data demonstrate that ROI regulate antiviral ASC expansion and have important implications for understanding the effects of antioxidants on humoral immunity during infection and immunization.
Complexity induced anisotropic bimodal intermittent turbulence in space plasmas

The “physics of complexity” in space plasmas is the central theme of this exposition. It is demonstrated that the sporadic and localized interactions of magnetic coherent structures arising from the plasma resonances can be the source for the coexistence of nonpropagating spatiotemporal fluctuations and propagating modes. Non-Gaussian probability distribution functions of the intermittent fluctuations from direct numerical simulations are obtained and discussed. Power spectra and local intermittency measures using the wavelet analyses are presented to display the spottiness of the small-scale turbulent fluctuations and the nonuniformity of coarse-grained dissipation that can lead to magnetic topological reconfigurations. The technique of the dynamic renormalization group is applied to the study of the scaling properties of such type of multiscale fluctuations. Charged particle interactions with both the propagating and nonpropagating portions of the intermittent turbulence are also described.
InlA Promotes Dissemination of Listeria monocytogenes to the Mesenteric Lymph Nodes during Food Borne Infection of Mice

Intestinal Listeria monocytogenes infection is not efficient in mice and this has been attributed to a low affinity interaction between the bacterial surface protein InlA and E-cadherin on murine intestinal epithelial cells. Previous studies using either transgenic mice expressing human E-cadherin or mouse-adapted L. monocytogenes expressing a modified InlA protein (InlAm) with high affinity for murine E-cadherin showed increased efficiency of intragastric infection. However, the large inocula used in these studies disseminated to the spleen and liver rapidly, resulting in a lethal systemic infection that made it difficult to define the natural course of intestinal infection. We describe here a novel mouse model of oral listeriosis that closely mimics all phases of human disease: (1) ingestion of contaminated food, (2) a distinct period of time during which L. monocytogenes colonize only the intestines, (3) varying degrees of systemic spread in susceptible vs. resistant mice, and (4) late stage spread to the brain. Using this natural feeding model, we showed that the type of food, the time of day when feeding occurred, and mouse gender each affected susceptibility to L. monocytogenes infection. Co-infection studies using L. monocytogenes strains that expressed either a high affinity ligand for E-cadherin (InlAm), a low affinity ligand (wild type InlA from Lm EGDe), or no InlA (ΔinlA) showed that InlA was not required to establish intestinal infection in mice. However, expression of InlAm significantly increased bacterial persistence in the underlying lamina propria and greatly enhanced dissemination to the mesenteric lymph nodes. Thus, these studies revealed a previously uncharacterized role for InlA in facilitating systemic spread via the lymphatic system after invasion of the gut mucosa.
Pharmacotherapy for borderline personality disorder: Cochrane systematic review of randomised trials

Background Many patients with borderline personality disorder receive pharmacological treatment, but there is uncertainty about the usefulness of such therapies. Aims To evaluate the evidence of effectiveness of pharmacotherapy in treating different facets of the psychopathology of borderline personality disorder. Method A Cochrane Collaboration systematic review and meta-analysis of randomised comparisons of drug v. placebo, drug v. drug, or single drug v. combined drug treatment in adult patients with borderline personality disorder was conducted. Primary outcomes were overall disorder severity as well as specific core symptoms. Secondary outcomes comprised associated psychiatric pathology and drug tolerability. Results Twenty-seven trials were included in which first- and second-generation antipsychotics, mood stabilisers, antidepressants and omega-3 fatty acids were tested. Most beneficial effects were found for the mood stabilisers topiramate, lamotrigine and valproate semisodium, and the second-generation antipsychotics aripiprazole and olanzapine. However, the robustness of findings is low, since they are based mostly on single, small studies. Selective serotonin reuptake inhibitors so far lack high-level evidence of effectiveness. Conclusions The current evidence from randomised controlled trials suggests that drug treatment, especially with mood stabilisers and second-generation antipsychotics, may be effective for treating a number of core symptoms and associated psychopathology, but the evidence does not currently support effectiveness for overall severity of borderline personality disorder. Pharmacotherapy should therefore be targeted at specific symptoms.
Effects of Size-Fractionated Particulate Matter on Cellular Oxidant Radical Generation in Human Bronchial Epithelial BEAS-2B Cells

The aim of the present study was to investigate the effects of size-fractionated (i.e., <1; 1–2.5, and 2.5–10 µm in an aerodynamic diameter) ambient particulate matter (PM) on reactive oxygen species (ROS) activity and cell viability in human bronchial epithelial cells (BEAS-2B). The PM samples were collected from an urban site (uPM) in Beijing and a steel factory site (sPM) in Anshan, China, from March 2013 to December 2014. Metal elements, organic and elemental carbon, and water-soluble inorganic ions in the uPM and sPM were analyzed. The cell viability and ROS generation in PM-exposed BEAS-2B cells were measured by MTS and DCFH-DA. The results showed that both uPM and sPM caused a decrease in the cell viability and an increase in ROS generation. The level of ROS measured in sPM1.0 was approximately triple that in uPM1.0. The results of correlation analysis showed that the ROS activity and cytotoxicity were related to different PM composition. Moreover, deferoxamine (DFO) significantly prevented the increase of ROS generation and the decrease of cell viability. Taken together, our results suggest that the metals absorbed on PM induced oxidant radical generation in BEAS-2B cells that could lead to impairment of pulmonary function.
Dietary patterns associated with metabolic syndrome, sociodemographic and lifestyle factors in young adults: the Bogalusa Heart Study

Abstract Objective To examine the association between dietary patterns (DP) and risk for metabolic syndrome (MetS); and to identify differences in DP by socio-economic, demographic and lifestyle factors. Design Dietary intake (from an FFQ), anthropometric/biochemical parameters and sociodemographic/lifestyle information (from a self-reported questionnaire) were evaluated, using a cross-sectional design. Statistical methods included principal component factor analysis, analysis of covariance and linear regression. All analyses were covariate-adjusted. Setting The Bogalusa Heart Study (1995–1996), USA. Subjects Young adults (19–39 years; n 995; 61 % females/39 % males; 80 % whites/20 % blacks) from a semi-rural southern US community were examined. Results The ‘Western Dietary Pattern’ (WDP) consisted of refined grains, French fries, high-fat dairy foods, cheese dishes, red meats, processed meats, eggs, snacks, sweets/desserts, sweetened beverages and condiments. The ‘Prudent Dietary Pattern’ (PDP) consisted of whole grains, legumes, vegetables, fruits, 100 % fruit juices, low-fat dairy products, poultry, clear soups and low-fat salad dressings. The DP explained 31 % of the dietary intake variance. Waist circumference (P = 0·02), triceps skinfold (P = 0·01), plasma insulin (P = 0·03), serum TAG (P = 0·05), and the occurrence of MetS (P = 0·03) were all inversely associated with PDP. Insulin sensitivity (P < 0·0005) was positively associated with PDP. Serum HDL cholesterol (P = 0·05) was inversely associated with WDP. Blacks consumed more servings from WDP than whites (P = 0·02). Females consumed more servings from PDP than males (P = 0·002). Those with >12 years of education consumed more servings from PDP than their counterparts (P < 0·0001). Current smokers consumed more servings from WDP than current non-smokers (P < 0·0001). Physically very active young adults consumed fewer servings from WDP than their sedentary counterparts (P = 0·02). Conclusions More studies are warranted to confirm these findings in other populations.
Long-term compliance with lipid-lowering medication after genetic screening for familial hypercholesterolemia.

BACKGROUND Familial hypercholesterolemia is a common lipid disorder that predisposes to premature cardiovascular disease. Lipid-lowering treatment of affected individuals is widely advocated, and maximum benefit can be obtained if medication is started early. A screening program for familial hypercholesterolemia is ongoing in the Netherlands since 1994. To assess the extent of treatment and therapy compliance, patients were followed up for 2 years after the diagnosis was established. METHODS Data were obtained by questionnaire. The 747 patients with familial hypercholesterolemia participating in the study were from the general community, and 62.4% were not receiving cholesterol-lowering medication. RESULTS The overall percentage of treated patients had risen from 37.6% at screening to 92.5% 1 year later and then decreased to 85.9% 2 years after screening. During follow-up, 6.4% of patients discontinued their medication and 12.0% of untreated patients never started medication for various reasons, but in the majority of cases as advised by their own physicians. The mean reduction in low-density lipoprotein cholesterol levels in previously untreated patients was 30.1% (from 219 to 153 mg/dL [5.7 to 4.0 mmol/L]). For those already receiving treatment, an additional reduction of 10.3% (from 195 to 175 mg/dL [5.0 to 4.5 mmol/L]) was obtained. CONCLUSIONS Most patients were receiving treatment 2 years after identification and had a positive attitude toward the screening program. However, the reduction of cholesterol levels still did not meet the internationally accepted goals of treatment. This underscores the fact that additional education is required to improve the treatment of individuals with familial hypercholesterolemia.
Computing the Expected Makespan of Task Graphs in the Presence of Silent Errors

Applications structured as Directed Acyclic Graphs (DAGs) of tasks correspond to a general model of parallel computation that occurs in many domains, including popular scientific workflows. DAG scheduling has received an enormous amount of attention, and several list-scheduling heuristics have been proposed and shown to be effective in practice. Many of these heuristics make scheduling decisions based on path lengths in the DAG. At large scale, however, compute platforms and thus tasks are subject to various types of failures with no longer negligible probabilities of occurrence. Failures that have recently received increasing attention are "silent errors," which cause a task to produce incorrect results even though it ran to completion. Tolerating silent errors is done by checking the validity of the results and re-executing the task from scratch in case of an invalid result. The execution time of a task then becomes a random variable, and so are path lengths. Unfortunately, computing the expected makespan of a DAG (and equivalently computing expected path lengths in a DAG) is a computationally difficult problem. Consequently, designing effective scheduling heuristics is preconditioned on computing accurate approximations of the expected makespan. In this work we propose an algorithm that computes a first order approximation of the expected makespan of a DAG when tasks are subject to silent errors. We compare our proposed approximation to previously proposed such approximations for three classes of application graphs from the field of numerical linear algebra. Our evaluations quantify approximation error with respect to a ground truth computed via a brute-force Monte Carlo method. We find that our proposed approximation outperforms previously proposed approaches, leading to large reductions in approximation error for low (and realistic) failure rates, while executing much faster.
Optimization of Enzymatic Hydrolysis of Channel Catfish Bones for Preparing Antimicrobial Agents

The bones of channel catfish (Ictalurus punctatus), a kind of fish processing waste, were hydrolyzed with one of five proteases (alcalase, neutrase, papain, pepsin, and trypsin) in order to generate antibacterial agents. The antibacterial activity of hydrolysates recovered through enzyme hydrolysis was tested by radial diffusion assay (RDA). Pepsin hydrolysate was found to have the greatest antibacterial activity. Thus, the conditions of hydrolysis with pepsin were optimized by response surface methodology (RSM). After screening and optimization, a quadratic model was proposed. The model predicted that the maximum diameter of clear zone, which suggests the optimum antibacterial activity, was around 20.2 mm with a hydrolysis condition of pH 3.5, reaction temperature of 40°C, enzyme-substrate ratio of 1.97/100 (g/g), substrate concentration of 0.15 g/mL, and reaction time of 4 h. Verification experiments under this condition showed a clear zone of 19.8 mm, which agreed well with the model's predicted value. This result indicates that RSM is an effective way to optimize the enzymatic hydrolysis of channel catfish bones to increase antibacterial activity, and the bones of channel catfish are promising resources for generating antibacterial components.
A Dynamic Approach to Secondary Processes in Associative Recognition

Associative recognition—the ability to discriminate between studied and novel associations—has been attributed to the operation of a recall-like process that is not engaged during recognition of single items. An alternative mechanism for associative recognition is the formation of a compound memory cue that incorporates relational information between the two elements of the association. These alternatives make different predictions about the dynamics of associative recognition as revealed by speed-accuracy trade-off (SAT) functions: if recall were operating, SAT functions should approach asymptotic performance at a faster rate for stronger associations, whereas a compound cue mechanism predicts that only asymptotic performance, not rate, should be affected by strength. In a review of the literature, we find that only asymptotic performance, not rate, is affected by the strength of studied associations, supporting the operation of a compound cue mechanism. We present a formal model of this mechanism as a direct outgrowth of a model of single-item recognition (Cox & Shiffrin, 2012) and use it to predict observed SAT curves for both single-item and associative recognition in a variety of experiments.