Miracle-dz/UniFAR-FTUs huggingface dataset:
Evaluation of Factors Affecting Vaccine Efficacy of Recombinant Marek's Disease Virus Lacking the Meq Oncogene in Chickens

Abstract We previously reported that deletion of the Meq gene from the oncogenic rMd5 virus rendered it apathogenic for chickens. Here we examined multiple factors affecting Marek's disease vaccine efficacy of this nonpathogenic recombinant Meq null rMd5 virus (rMd5ΔMeq). These factors included host genetics (MHC haplotype), strain or dose of challenge virus, vaccine challenge intervals, and maternal antibody status of the vaccinated chicks. Studies on host genetics were carried out in five chicken lines comprising four different MHC B-haplotypes. Results showed that chicken lines tested were highly protected, with protective indexes of 100% (B*2/*15), 94% (B*2/*2), 87% (B*19/*19), and 83% (B*21/*21). At a challenge dose above 8000 plaque-forming units, differences in protection were observed between the two highly virulent strains examined (648A and 686). The interval between vaccination and challenge indicated a protective efficacy from 0 to 2 days varied greatly (12%–82%) after challenge with vv+686, the most virulent virus. Less variation and significant protection began at 3 days post vaccination and reached a maximum at 5 days post vaccination with about 80%–100% protection. Taken together, our results indicate that the factors examined in this study are important for vaccine efficacy and need to be considered in comparative evaluations of vaccines.
Personality Assessment Inventory substance-use scales: Convergent and discriminant relations with the Addiction Severity Index in a residential chemical dependence treatment setting.

This study examined the convergent and discriminant validity of the Alcohol Problems (ALC) and Drug Problems (DRG) scales of the Personality Assessment Inventory (PAI; Morey, 1991). Participants were 103 male veterans (mean age = 41.7 years) in a Veterans Affairs residential treatment for chemical dependence. The PAI was compared to the Addiction Severity Index (ASI; McLellan et al., 1992), a semi structured interview. The sampling strategy that was used resulted in a diverse sample (66% African American, 33% Caucasian; 59% with primary alcohol diagnosis, 38% with primary drug diagnosis, 56% with comorbid alcohol and drug diagnoses) and adequately variable ALC and DRG scores. Results supported the convergent validity of both the ALC and DRG scales in relation to both the ASI and substance-use diagnosis. The ALC scale also demonstrated excellent discriminant validity, whereas the discriminant validity of the DRG scale was less impressive. Despite this, the DRG scale performed better in the current diverse sample than observed in an earlier study (Alterman et al., 1995). Recommendations for the use of the PAI in chemical dependence treatment settings are discussed.
SL(2;Z) Action On Three-Dimensional Conformal Field Theories With Abelian Symmetry

On the space of three-dimensional conformal field theories with U(1) symmetry and a chosen coupling to a background gauge field, there is a natural action of the group $SL(2,{\bf Z})$. The generator $S$ of $SL(2,{\bf Z})$ acts by letting the background gauge field become dynamical, an operation considered recently by Kapustin and Strassler in explaining three-dimensional mirror symmetry. The other generator $T$ acts by shifting the Chern-Simons coupling of the background field. This $SL(2,{\bf Z})$ action in three dimensions is related by the AdS/CFT correspondence to $SL(2,{\bf Z})$ duality of low energy U(1) gauge fields in four dimensions.
Human In vivo Dose-Response to Controlled, Low-Dose Low Linear Energy Transfer Ionizing Radiation Exposure

Purpose: The effect of low doses of low–linear energy transfer (photon) ionizing radiation (LDIR, <10 cGy) on human tissue when exposure is under normal physiologic conditions is of significant interest to the medical and scientific community in therapeutic and other contexts. Although, to date, there has been no direct assessment of the response of human tissue to LDIR when exposure is under normal physiologic conditions of intact three-dimensional architecture, vasculature, and cell-cell contacts (between epithelial cells and between epithelial and stromal cells). Experimental Design: In this article, we present the first data on the response of human tissue exposed in vivo to LDIR with precisely controlled and calibrated doses. We evaluated transcriptomic responses to a single exposure of LDIR in the normal skin of men undergoing therapeutic radiation for prostate cancer (research protocol, Health Insurance Portability and Accountability Act–compliant, Institutional Review Board–approved). Using newly developed biostatistical tools that account for individual splice variants and the expected variability of temporal response between humans even when the outcome is measured at a single time, we show a dose-response pattern in gene expression in a number of pathways and gene groups that are biologically plausible responses to LDIR. Results: Examining genes and pathways identified as radiation-responsive in cell culture models, we found seven gene groups and five pathways that were altered in men in this experiment. These included the Akt/phosphoinositide-3-kinase pathway, the growth factor pathway, the stress/apoptosis pathway, and the pathway initiated by transforming growth factor-β signaling, whereas gene groups with altered expression included the keratins, the zinc finger proteins and signaling molecules in the mitogen-activated protein kinase gene group. We show that there is considerable individual variability in radiation response that makes the detection of effects difficult, but still feasible when analyzed according to gene group and pathway. Conclusions: These results show for the first time that low doses of radiation have an identifiable biosignature in human tissue, irradiated in vivo with normal intact three-dimensional architecture, vascular supply, and innervation. The genes and pathways show that the tissue (a) does detect the injury, (b) initiates a stress/inflammatory response, (c) undergoes DNA remodeling, as suggested by the significant increase in zinc finger protein gene expression, and (d) initiates a “pro-survival” response. The ability to detect a distinct radiation response pattern following LDIR exposure has important implications for risk assessment in both therapeutic and national defense contexts.
Environmental heterogeneity, dispersal mode, and co-occurrence in stream macroinvertebrates

Both environmental heterogeneity and mode of dispersal may affect species co-occurrence in metacommunities. Aquatic invertebrates were sampled in 20–30 streams in each of three drainage basins, differing considerably in environmental heterogeneity. Each drainage basin was further divided into two equally sized sets of sites, again differing profoundly in environmental heterogeneity. Benthic invertebrate data were divided into three groups of taxa based on overland dispersal modes: passive dispersers with aquatic adults, passive dispersers with terrestrial winged adults, and active dispersers with terrestrial winged adults. The co-occurrence of taxa in each dispersal mode group, drainage basin, and heterogeneity site subset was measured using the C-score and its standardized effect size. The probability of finding high levels of species segregation tended to increase with environmental heterogeneity across the drainage basins. These patterns were, however, contingent on both dispersal mode and drainage basin. It thus appears that environmental heterogeneity and dispersal mode interact in affecting co-occurrence in metacommunities, with passive dispersers with aquatic adults showing random patterns irrespective of environmental heterogeneity, and active dispersers with terrestrial winged adults showing increasing segregation with increasing environmental heterogeneity.
Clinical Characteristics and Outcome of Acute Heart Failure in Korea: Results from the Korean Acute Heart Failure Registry (KorAHF)

Background and Objectives The burden of heart failure has increased in Korea. This registry aims to evaluate demographics, clinical characteristics, management, and long-term outcomes in patients hospitalized for acute heart failure (AHF). Subjects and Methods We prospectively enrolled a total of 5625 consecutive subjects hospitalized for AHF in one of 10 tertiary university hospitals from March 2011 to February 2014. Descriptive statistics were used to determine the baseline characteristics of the study population and to compare them with those from other registries. Results The mean age was 68.5±14.5 years, 53.2% were male, and 52.2% had de novo heart failure. The mean systolic and diastolic blood pressures were 131.2±30.3 mmHg and 78.6±18.8 mmHg at admission, respectively. The left ventricular ejection fraction was ≤40% in 60.5% of patients. Ischemia was the most frequent etiology (37.6%) and aggravating factor (26.3%). Angiotensin converting enzyme inhibitors/angiotensin receptor blockers, beta-blockers, and aldosterone antagonists were prescribed in 68.8%, 52.2%, and 46.6% of the patients at discharge, respectively. Compared with the previous registry performed in Korea a decade ago, extracorporeal membrane oxygenation (ECMO) and heart transplantation have been performed more frequently (ECMO 0.8% vs. 2.8%, heart transplantation 0.3% vs. 1.2%), and in-hospital mortality decreased from 7.6% to 4.8%. However, the total cost of hospital care increased by 40%, and one-year follow-up mortality remained high. Conclusion While the quality of acute clinical care and AHF-related outcomes have improved over the last decade, the long-term prognosis of heart failure is still poor in Korea. Therefore, additional research is needed to improve long-term outcomes and implement cost-effective care.
Conventional tillage decreases the abundance and biomass of earthworms and alters their community structure in a global meta‐analysis

The adoption of less intensive soil cultivation practices is expected to increase earthworm populations and their contributions to ecosystem functioning. However, conflicting results have been reported on the effects of tillage intensity on earthworm populations, attributed in narrative reviews to site‐dependent differences in soil properties, climatic conditions and agronomic operations (e.g. fertilization, residue management and chemical crop protection). We present a quantitative review based on a global meta‐analysis, using paired observations from 165 publications performed over 65 years (1950–2016) across 40 countries on five continents, to elucidate this long‐standing unresolved issue. Results showed that disturbing the soil less (e.g. no‐tillage and conservation agriculture [CA]) significantly increased earthworm abundance (mean increase of 137% and 127%, respectively) and biomass (196% and 101%, respectively) compared to when the soil is inverted by conventional ploughing. Earthworm population responses were more pronounced when the soil had been under reduced tillage (RT) for a long time (>10 years), in warm temperate zones with fine‐textured soils, and in soils with higher clay contents (>35%) and low pH (<5.5). Furthermore, retaining organic harvest residues amplified this positive response to RT, whereas the use of the herbicide glyphosate did not significantly affect earthworm population responses to RT. Additional meta‐analyses confirmed that epigeic and, more importantly, the bigger‐sized anecic earthworms were the most sensitive ecological groups to conventional tillage. In particular, the deep burrower Lumbricus terrestris exhibited the strongest positive response to RT, increasing in abundance by 124% more than the overall mean of all 13 species analysed individually. The restoration of these two important ecological groups of earthworms and their burrowing, feeding and casting activities under various forms of RT will ensure the provision of ecosystem functions such as soil structure maintenance and nutrient cycling by “nature's plough. ”
Impact of Magnet Geometry on Output of a Dynamo-Type HTS Flux Pump

A superconducting flux pump based on a high-temperature superconducting (HTS) dynamo has been demonstrated which employs rotating permanent magnets and a ReBCO conductor stator wire. This device is capable of injecting large dc currents (>100 A) into industrial superconducting magnet coils. Dynamic resistance, due to the interaction of the dc current with the ac magnetic field at the stator, provides a performance limit for this type of HTS dynamo exciter. It has been shown for a given device, the output of the HTS dynamo can be described by a simple circuit model linking short-circuit current (<italic>I</italic><sub>sc</sub>), dynamic resistance (<italic>R</italic><sub>d</sub>), and open-circuit voltage (<italic>V</italic><sub>oc</sub>). <italic>I</italic><sub>sc</sub> represents the maximum dc current that can be delivered by the dynamo to a series-connected superconducting circuit and is found to be independent of rotational frequency for a fixed device geometry. We have recently demonstrated that this dynamo effect can be applied to excite a closed superconducting circuit through the cryostat wall, such that all active components of the dynamo are located outside of the cryogenic envelope. Here, we report experimental results which explore the relationship between rotor magnet geometry and ReBCO stator wire width on the output performance of a simple HTS dynamo. We characterize the effect of magnet orientation, aspect ratio and shape, at fixed flux gap, on <italic>I </italic><sub>sc</sub>, <italic>R</italic><sub>d</sub>, and <italic>V</italic><sub>oc</sub>.
The Rtr1p CTD phosphatase autoregulates its mRNA through a degradation pathway involving the REX exonucleases

Rtr1p is a phosphatase that impacts gene expression by modulating the phosphorylation status of the C-terminal domain of the large subunit of RNA polymerase II. Here, we show that Rtr1p is a component of a novel mRNA degradation pathway that promotes its autoregulation through turnover of its own mRNA. We show that the 3′UTR of the RTR1 mRNA contains a cis element that destabilizes this mRNA. RTR1 mRNA turnover is achieved through binding of Rtr1p to the RTR1 mRNP in a manner that is dependent on this cis element. Genetic evidence shows that Rtr1p-mediated decay of the RTR1 mRNA involves the 5′-3′ DExD/H-box RNA helicase Dhh1p and the 3′-5′ exonucleases Rex2p and Rex3p. Rtr1p and Rex3p are found associated with Dhh1p, suggesting a model for recruiting the REX exonucleases to the RTR1 mRNA for degradation. Rtr1p-mediated decay potentially impacts additional transcripts, including the unspliced BMH2 pre-mRNA. We propose that Rtr1p may imprint its RNA targets cotranscriptionally and determine their downstream degradation mechanism by directing these transcripts to a novel turnover pathway that involves Rtr1p, Dhh1p, and the REX family of exonucleases.
Work-family balance through border theory lens: the case of a company “driving in the fast lane”

Purpose – The purpose of this paper is to seek to provide support and extend work-family Border Theory (BT) in order to investigate organizational and individual factors that determine the complex nature of work-family balance (WFB). Design/methodology/approach – Qualitative research was conducted in a company in Greece. In total, 20 in-depth interviews were conducted. Data analysis was guided by interpretative phenomenological analysis. Findings – The key findings illustrate that strong borders protect the investigated, powerful, work domain and expand only to accommodate its’ needs. In congruence with BT, employees choose to be central participants in the powerful, highly impermeable and inflexibly bordered, work domain. The deeply entrenched organizational culture, as well as leaders’ behavior and leadership style, support the development of an array of positive work attitudes which boost central participation in the work domain. Due to the strongly bordered work setting, employees were found to choose.
Pathologic Findings in Weedy (Phyllopteryx taeniolatus) and Leafy (Phycodurus eques) Seadragons

A retrospective study of the pathologic findings in weedy (Phyllopteryx taeniolatus) and leafy (Phycodurus eques) seadragons was performed on specimens submitted to 2 reference laboratories from 1994 to 2012 to determine the range and occurrence of diseases affecting aquarium-held populations. One hundred two and 94 total diagnoses were recorded in weedy and leafy seadragons, respectively. Two of the more common etiologic diagnoses in both species were mycobacteriosis and scuticociliatosis, whereas myxozoanosis was common in weedy seadragons. Metazoan parasite infections were less common etiologic diagnoses. There were no correlations between mycobacteriosis and ciliate protozoan infections in either species. Myxozoanosis was usually found in combination with other diseases and, except for 1 case, was restricted to weedy seadragons. Phaeohyphomycosis, nonmycobacterial bacterial infections, and trauma were also important but less frequent diagnoses. Intestinal coccidiosis was found in weedy but not leafy seadragons. Mineralization of the swim bladder was detected in 26 of 197 leafy seadragons and only 2 of 257 weedy seadragons. Although weedy and leafy seadragons share certain diseases of significance to exhibit populations, there are diseases unique to each species about which the veterinary pathologist, clinician, or diagnostician should be aware.
PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer

Immune checkpoint inhibition represents a major recent breakthrough in the treatment of malignant diseases including breast cancer. Blocking the programmed death receptor-1 (PD-1) and its ligand, PD-L1, has shown impressive antitumor activity and may lead to durable long-term disease control, especially in the triple-negative subtypes of breast cancer (TNBC). Although immune checkpoint blockade is generally well tolerated, specific immune-related adverse events (irAEs) may occur. This review summarizes the clinical efficacy, perspectives, and future challenges of using PD-1/PD-L1-directed antibodies in the treatment of breast cancer.
Discovery of 10 μm silicate emission in quasars : Evidence of the agn unification scheme

According to the unified scheme, AGN are surrounded by a dust-torus, and the observed diversity of AGN properties results from the different orientations relative to our line of sight. The strong resonance of silicate dust at 10 μ m is therefore, as expected, seen in absorption towards many type-2 AGN. In type-1 AGN, it should be seen in emission because the hot inner surface of the dust torus becomes visible. However, this has not been observed so far, thus challenging the unification scheme or leading to exotic modifications of the dust-torus model. Here we report the discovery of the 10 μ m silicate feature in emission in two luminous quasars with the Infrared Spectrograph of the Spitzer Space Telescope.
Achievable Capacity of a Spectrum Sharing System over Hyper Fading Channels

Cognitive radio with spectrum sharing feature is a promising technique to address the spectrum under-utilization problem in dynamically changing environments. In this paper, achievable capacity gain of spectrum sharing systems over dynamic fading environments is studied. For the analysis, a theoretical fading model called hyper fading model that is suitable to the dynamic nature of cognitive radio channel is proposed. Closed-form expression of probability density function (PDF) and cumulative density function (CDF) of the signal-to-noise ratio (SNR) for secondary users in spectrum sharing systems are derived. In addition, the capacity gains achievable with spectrum sharing systems in high and low power regions are obtained. Numerical simulations are performed to study the effects of different fading figures, average powers, interference temperature, and number of secondary users on the achievable capacity.
5'-Chloro-5'-deoxy-(±)-ENBA, a Potent and Selective Adenosine A1 Receptor Agonist, Alleviates Neuropathic Pain in Mice Through Functional Glial and Microglial Changes without Affecting Motor or Cardiovascular Functions

This study was undertaken in order to investigate the effect of chronic treatment with 5′-chloro-5′-deoxy-(±)-ENBA, a potent and highly selective agonist of human adenosine A1 receptor, on thermal hyperalgesia and mechanical allodynia in a mouse model of neuropathic pain, the Spared Nerve Injury (SNI) of the sciatic nerve. Chronic systemic administration of 5′-chloro-5′-deoxy-(±)-ENBA (0.5 mg/kg, i.p.) reduced both mechanical allodynia and thermal hyperalgesia 3 and 7 days post-SNI, in a way prevented by DPCPX (3 mg/kg, i.p.), a selective A1 adenosine receptor antagonist, without exerting any significant change on the motor coordination or arterial blood pressure. In addition, a single intraperitoneal injection of 5′-chloro-5′-deoxy-(±)-ENBA (0.5 mg/kg, i.p.) 7 days post-SNI also reduced both symptoms for at least two hours. SNI was associated with spinal changes in microglial activation ipsilaterally to the nerve injury. Activated, hypertrophic microglia were significantly reduced by 5′-chloro-5′-deoxy-(±)-ENBA chronic treatment. Our results demonstrated an involvement of adenosine A1 receptor in the amplified nociceptive thresholds and in spinal glial and microglial changes occurred in neuropathic pain, without affecting motor coordination or blood pressure. Our data suggest a possible use of adenosine A1 receptor agonist in neuropathic pain symptoms.
Relationships of consumer sensory ratings, marbling score, and shear force value to consumer acceptance of beef strip loin steaks.

Logistic regression was used to quantify and characterize the effects of changes in marbling score, Warner-Bratzler shear force (WBSF), and consumer panel sensory ratings for tenderness, juiciness, or flavor on the probability of overall consumer acceptance of strip loin steaks from beef carcasses (n = 550). Consumers (n = 489) evaluated steaks for tenderness, juiciness, and flavor using nine-point hedonic scales (1 = like extremely and 9 = dislike extremely) and for overall steak acceptance (satisfied or not satisfied). Predicted acceptance of steaks by consumers was high (> 85%) when the mean consumer sensory rating for tenderness,juiciness, or flavor for a steak was 3 or lower on the hedonic scale. Conversely, predicted consumer acceptance of steaks was low (< or = 10%) when the mean consumer rating for tenderness, juiciness, or flavor for a steak was 5 or higher on the hedonic scale. As mean consumer sensory ratings for tenderness, juiciness, or flavor decreased from 3 to 5, the probability of acceptance of steaks by consumers diminished rapidly in a linear fashion. These results suggest that small changes in consumer sensory ratings for these sensory traits have dramatic effects on the probability of acceptance of steaks by consumers. Marbling score displayed a weak (adjusted R2 = 0.053), yet significant (P < 0.01), relationship to acceptance of steaks by consumers, and the shape of the predicted probability curve for steak acceptance was approximately linear over the entire range of marbling scores (Traces67 to Slightly Abundant97), suggesting that the likelihood of consumer acceptance of steaks increases approximately 10% for each full marbling score increase between Slight to Slightly Abundant. The predicted probability curve for consumer acceptance of steaks was sigmoidal for the WBSF model, with a steep decline in predicted probability of acceptance as WBSF values increased from 3.0 to 5.5 kg. Changes in WBSF within the high (> 5.5 kg) or low (< 3.0 kg) portions of the range of WBSF values had little effect on the probability of consumer acceptance of steaks.