Miracle-dz/UniFAR-FTUs huggingface dataset:
Characterization of JNJ-42847922, a Selective Orexin-2 Receptor Antagonist, as a Clinical Candidate for the Treatment of Insomnia

Dual orexin receptor antagonists have been shown to promote sleep in various species, including humans. Emerging research indicates that selective orexin-2 receptor (OX2R) antagonists may offer specificity and a more adequate sleep profile by preserving normal sleep architecture. Here, we characterized JNJ-42847922 ([5-(4,6-dimethyl-pyrimidin-2-yl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-(2-fluoro-6-[1,2,3]triazol-2-yl-phenyl)-methanone), a high-affinity/potent OX2R antagonist. JNJ-42847922 had an approximate 2-log selectivity ratio versus the human orexin-1 receptor. Ex vivo receptor binding studies demonstrated that JNJ-42847922 quickly occupied OX2R binding sites in the rat brain after oral administration and rapidly cleared from the brain. In rats, single oral administration of JNJ-42847922 (3–30 mg/kg) during the light phase dose dependently reduced the latency to non–rapid eye movement (NREM) sleep and prolonged NREM sleep time in the first 2 hours, whereas REM sleep was minimally affected. The reduced sleep onset and increased sleep duration were maintained upon 7-day repeated dosing (30 mg/kg) with JNJ-42847922, then all sleep parameters returned to baseline levels following discontinuation. Although the compound promoted sleep in wild-type mice, it had no effect in OX2R knockout mice, consistent with a specific OX2R-mediated sleep response. JNJ-42847922 did not increase dopamine release in rat nucleus accumbens or produce place preference in mice after subchronic conditioning, indicating that the compound lacks intrinsic motivational properties in contrast to zolpidem. In a single ascending dose study conducted in healthy subjects, JNJ-42847922 increased somnolence and displayed a favorable pharmacokinetic and safety profile for a sedative/hypnotic, thus emerging as a promising candidate for further clinical development for the treatment of insomnia.
Chloridobis{N-[(dimethylamino)dimethylsilyl]-2,6-dimethylanilido-κ2 N,N′}titanium(III)

In the monomeric title titanium(III) compound, [Ti(C12H21N2Si)2Cl], the metal atom is surrounded by two N–silylated anilide ligands in an N,N′′-chelating mode. The two ends of the N—Si—N chelating unit exhibit different affinity to the metal center. The Ti—Namine bond is longer than the Ti—Nanilide bond by about 0.29 Å. The two ligands are arranged trans to each other and the molecule demonstrates a pseudo-twofold rotation along the axis of the Ti—Cl bond. The five–coordinate Ti atom demonstrates a highly distorted trigonal-bipyramidal geometry.
Further Results on 3 − equitable Labeling

A mapping f from the vertex set of a graph G to the set {0, 1, 2} is called 3-equitable labeling, if the edge labels are produced by the absolute difference of labels of end vertices such that the absolute difference of number of vertices of G labeled with 0, 1 and 2 differ by atmost 1 and similarly the absolute difference of number of edges of G labeled with 0, 1 and 2 differ by atmost 1. A graph which admits 3-equitable labeling is called 3-equitable graph. In this paper we prove that the graph obtained by joining two copies of fan graph by a path of arbitrary length is 3-equitable. We also prove similar results for wheel, helm, gear and cycle with one pendant edge.
Hand eczema and long-term prognosis in atopic dermatitis.

A follow-up study of 1177 adult patients who had had atopic dermatitis (AD) (Groups 1 and 2) or respiratory allergy (Group 3) in childhood is reported. Patients who had had AD in childhood had received in-patient (Group 1) or out-patient treatment (Group 2) for their dermatitis. 183 patients in Group 1 and 162 in Group 2 were examined clinically. Further, 445 patients who had recently been treated for hand eczema at a department for occupational dermatoses were studied (Group 5). A group of 199 people who had no personal or family history of atopy served as controls (Group 4). The essential findings were as follows: The healing rate was lower (38%) in patients with severe (Group 1) than in those with moderate (60%) childhood dermatitis (Group 2). Although the healing rate was comparatively low in both groups, persistent eczema was in most cases of mild degree. The commonest localization of persistent dermatitis was the hands. The AD had developed earlier in patients who had had severe childhood dermatitis than in those whose childhood AD was moderate. Severe childhood AD was also associated with a significantly higher frequency of family history of atopy and associated respiratory allergy. The inheritance pattern was specific for the different types of atopic disease. A family history of AD was significantly commoner in people with AD than in people with respiratory allergy, and, conversely, people with a family history of respiratory allergy had developed asthma or allergic rhinitis rather than AD. The serum IgE level was raised in 45% and 26% of the clinically examined individuals in Groups 1 and 2, respectively. A comparatively large proportion of patients with persistent or recurrent dermatitis had normal IgE values. There was a strong correlation between the extent of persistent dermatitis and serum IgE levels. It is concluded that the serum IgE cannot be used to establish the diagnosis of atopic dermatitis. The number of contact sensitized people was greater in Group 2 (23%) than in Group 1 (17%). Occurrence of contact sensitivity, which was demonstrable in a total of 20% of the patch tested individuals from Groups 1 and 2, was not correlated to prevalence of healing at the time of examination. Fragrance-mix and balsam of Peru were the commonest contact sensitizers. People with a history of AD showed a higher incidence of recurrent (greater than 5 episodes per year) cold sores, upper respiratory infection, and herpes zoster than non-atopic controls. (ABSTRACT TRUNCATED AT 400 WORDS)
Hierarchical Analysis of Cardiovascular Risk Factors in Relation to the Development of Acute Coronary Syndromes, in Different Parts of Greece: The CARDIO2000 Study

During 2000 to 2002, 700 men (59 ± 10 years) and 148 women (65 ± 9 years) patients with first event of an ACS were randomly selected from cardiology clinics of Greek regions. Afterwards, 1078 population-based, age-matched and sex-matched controls were randomly selected from the same hospitals. The frequency ratio between men and women in the case series of patients was about 4:1, in both south and north Greek areas. Hierarchical classification analysis showed that for north Greek areas family history of coronary heart disease, hypercholesterolemia, hypertension, diabetes (explained variability 35%), and less significantly, dietary habits, smoking, body mass index, and physical activity status (explained variability 4%) were associated with the development of ACS, whereas for south Greek areas hypercholesterolemia, family history of coronary heart disease, diabetes, smoking, hypertension, dietary habits, physical activity (explained variability 34%), and less significantly body mass index (explained variability <1%), were associated with the development of the disease.
Learning complex cell invariance from natural videos: A plausibility proof

Abstract : One of the most striking features of the cortex is its ability to wire itself. Understanding how the visual cortex wires up through development and how visual experience refines connections into adulthood is a key question for Neuroscience. While computational models of the visual cortex are becoming increasingly detailed, the question of how such architecture could self-organize through visual experience is often overlooked. Here we focus on the class of hierarchical feed-forward models of the ventral stream of the visual cortex, which extend the classical simple-to-complex cells model by Hubel and Wiesel to extra-striate areas, and have been shown to account for a host of experimental data. Such models assume two functional classes of simple and complex cells with specific predictions about their respective wiring and resulting functionalities. In these networks, the issue of learning, especially for complex cells, is perhaps the least well understood. In fact, in most of these models, the connectivity between simple and complex cells is not learned but rather hard-wired. Several algorithms have been proposed for learning invariances at the complex cell level based on a trace rule to exploit the temporal continuity of sequences of natural images.
Effects of prior warm-up regime on severe-intensity cycling performance.

PURPOSE The purpose of the present study was to determine the effect of three different warm-up regimes on cycling work output during a 7-min performance trial. METHODS After habituation to the experimental methods, 12 well-trained cyclists completed a series of 7-min performance trials, involving 2 min of constant-work rate exercise at approximately 90% VO2max and a further 5 min during which subjects attempted to maximize power output. This trial was performed without prior intervention and 10 min after bouts of moderate, heavy, or sprint exercise in a random order. Pulmonary gas exchange was measured breath by breath during all performance trials. RESULTS At the onset of the performance trial, baseline blood [lactate] was significantly elevated after heavy and sprint but not moderate exercise (mean +/- SD: control, 1.0 +/- 0.3 mM; moderate, 1.0 +/- 0.2 mM; heavy, 3.0 +/- 1.1 mM; sprint, 5.9 +/- 1.5 mM). All three interventions significantly increased the amplitude of the primary VO2 response (control, 2.59 +/- 0.28 L x min(-1); moderate, 2.69 +/- 0.27 L x min(-1); heavy, 2.78 +/- 0.26 L x min(-1); sprint, 2.78 +/- 0.30 L x min(-1)). Mean power output was significantly increased by prior moderate and heavy exercise but not significantly reduced after sprint exercise (control, 330 +/- 42 W; moderate, 338 +/- 39 W; heavy, 339 +/- 42 W; sprint, 324 +/- 45 W). CONCLUSIONS These data indicate that priming exercise performed in the moderate- and heavy-intensity domains can improve severe-intensity cycling performance by ~2-3%, the latter condition doing so despite a mild lactacidosis being present at exercise onset.
Association of haptoglobin phenotypes with clinical features of preterm labor disease.

Preterm birth means the birth before thirty seven week of pregnancy that causes a lot of complications for the baby. Variety factors are suggested to be involved in disease. In this study, we decided to evaluate haptoglobin (Hp) phenotypes association with clinical features of patients suffered from premature delivery to understand better the possible correlation of genetic and clinical features in this disease. This cross sectional analytic descriptive study has been carried out in two groups of 120 women, 60 with preterm and 60 with term labor. Patients were selected with previously diagnosed by a gynecologist with preterm birth in hospital during the study period. After performing diagnostic tests, the frequency of each haptoglobin phenotype in the two groups was analyzed using the X2 test and SPSS software. The maximum serum haptoglobin phenotype frequency in patients with Hp2-2, was 43 (71.7%) whereas in healthy individuals, 35 (58.3%). No statistically significant differences between the two groups was found (P=0.310). But based on some patients clinical features such as their history of preterm delivery, previous history of recurrent abortions and history of preterm delivery in their family, significant association was found with Hp2-2 compared with healthy control (P<0.003). This study showed that Hp2-2 phenotypes levels in the case group was higher than in control but the factors influencing the presence or absence of preterm labor is clinically various.
Examination of the social-environmental and motivational processes operating in dance contexts : a self-determination theory approach

Grounded in the self-determination (SDT; Deci & Ryan, 1985, 2000) and achievement goal (Nicholls, 1989) theories this thesis had the broad aim of expanding current knowledge and theoretical understanding of motivational processes. This was achieved via four studies in dance addressing contemporary conceptual and methodological issues raised in the motivation literature. The studies aimed to progress the conceptualisation and measurement of key motivational constructs (i.e., the teacher-created motivational climate and motivation regulations) by examining their application in dance using quantitative and qualitative methods. Additionally, the studies aimed to enhance understanding of the motivational processes via which the motivational climate, as a multi-dimensional construct, predicts dancers’ psychological well- and ill-being. Specifically, the mediating roles of basic psychological needs and motivation regulations between dancers’ perceptions of the motivational climate and affective states were examined. Collectively the thesis supports the central features of the SDT framework, including Duda’s (2013) conceptualisation of the motivational climate as multi-dimensional, and basic psychological need thwarting (as detailed in Bartholomew, Ntoumanis, Ryan, & Thogersen-Ntoumani, 2011b). The studies in this thesis will substantiate the need for and inform theoretically-grounded interventions which aim to educate teachers in how they can support dancers’ psychological well-being in a variety of dance settings.
Complexity Metrics in an Incremental Right-Corner Parser

Hierarchical HMM (HHMM) parsers make promising cognitive models: while they use a bounded model of working memory and pursue incremental hypotheses in parallel, they still achieve parsing accuracies competitive with chart-based techniques. This paper aims to validate that a right-corner HHMM parser is also able to produce complexity metrics, which quantify a reader's incremental difficulty in understanding a sentence. Besides defining standard metrics in the HHMM framework, a new metric, embedding difference, is also proposed, which tests the hypothesis that HHMM store elements represents syntactic working memory. Results show that HHMM surprisal outperforms all other evaluated metrics in predicting reading times, and that embedding difference makes a significant, independent contribution.
Clinical Significance of an HPV DNA Chip Test with Emphasis on HPV-16 and/or HPV-18 Detection in Korean Gynecological Patients

Background: Human papillomavirus (HPV) is a major risk factor for cervical cancer. Methods: We evaluated the clinical significance of the HPV DNA chip genotyping assay (MyHPV chip, Mygene Co.) compared with the Hybrid Capture 2 (HC2) chemiluminescent nucleic acid hybridization kit (Digene Corp.) in 867 patients. Results: The concordance rate between the MyHPV chip and HC2 was 79.4% (kappa coefficient, κ = 0.55). The sensitivity and specificity of both HPV tests were very similar (approximately 85% and 50%, respectively). The addition of HPV result (either MyHPV chip or HC2) to cytology improved the sensitivity (95%, each) but reduced the specificity (approximately 30%, each) compared with the HPV test or cytology alone. Based on the MyHPV chip results, the odds ratio (OR) for ≥ high-grade squamous intraepithelial lesions (HSILs) was 9.9 in the HPV-16/18 (+) group and 3.7 in the non-16/18 high-risk (HR)-HPV (+) group. Based on the HC2 results, the OR for ≥ HSILs was 5.9 in the HR-HPV (+) group. When considering only patients with cytological diagnoses of “negative for intraepithelial lesion or malignancy” and “atypical squamous cell or atypical glandular cell,” based on the MyHPV chip results, the ORs for ≥ HSILs were 6.8 and 11.7, respectively, in the HPV-16/18 (+) group. Conclusions: The sensitivity and specificity of the MyHPV chip test are similar to the HC2. Detecting HPV-16/18 with an HPV DNA chip test, which is commonly used in many Asian countries, is useful in assessing the risk of high-grade cervical lesions.
Adolescent Personality, Confucian Values, Parenting Typologies and Adolescent Behavioral Outcomes: A Study in South Korea

The purpose of this study was to examine the associations among adolescent personality traits, Confucian values, parenting styles (and psychological control), and aggressive behaviors in South Korean families. Although the use of aggression by Korean adolescents has increased in contemporary Korean society, there is a lack of research on how adolescent personality traits and cultural values impact adolescent behavioral outcomes through parenting styles and psychological control. The sample included 361 parents (mothers and fathers) and their adolescents (7 and 8 grade) and the teachers of participating adolescents. Results indicated that adolescents’ agreeableness, extraversion, and neuroticism were associated with adolescent overt, relational, and cyber aggression. Adolescents’ Confucian values were associated with their relational and cyber aggression. Mothers’ Confucian values were associated with their adolescents’ overt aggression, and fathers’ Confucian values were related to their adolescents’ cyber aggression. Mothers’ and fathers’ authoritarianism did play an important role as a mediator in the relationship between adolescents’ personality traits and their aggression. Adolescents’ personality traits were associated with their overt aggression via a mediating role of fathers’ and mothers’ psychological control. Findings revealed that parenting styles and psychological control did not mediate the relationship between adolescent and parental Confucian values and adolescents’ aggressive behavioral problems. ADOLESCENT PERSONALITY, CONFUCIAN VALUES, PARENTING TYPOLOGIES AND ADOLESCENT BEHAVIORAL OUTCOMES: A STUDY IN SOUTH KOREA By Yo Ok Chang B.A. Kyonggi University, Gyeonggi, Korea, 2002 M.A. Kyonggi University, Seoul, Korea, 2004 M.S. Syracuse University, 2008
The older sickle cell patient

The lifespan of sickle cell patients has increased substantially. We chose to compare the attributes of older sickle cell patients with younger ones within the confines of a single institutional study serving the local Bronx population. Laboratory and clinical assessments from 40 patients with sickle cell disease over 40 years of age were compared to 40 patients under 30 years of age. When the older group was compared to the younger group, hemoglobin, indirect bilirubin, and platelet counts were significantly lower. Creatinine clearances were lower and BUN levels were higher in the older group. Although the prevalence of radiographically measured cardiomegaly was significantly higher in the older group, systolic and diastolic blood pressures remained unchanged. The number of crises and number of admissions were higher in the younger group than in the older, but there was wide variation, and no significant differences could be detected; days spent in hospital over the previous 2 years did not differ. No statistically significant differences were observed for absolute reticulocyte count, MCV, % HbF, white cell count, liver function tests, or oxygen saturation. Comparing genders within age groups, younger males had higher hemoglobin levels and absolute reticulocyte counts than younger females, while only the older females had higher HbF levels than the corresponding males. Lower levels of hemoglobin associated with older age may reflect decreased hematopoietic potential that may in part be due to decreased renal function. Lower platelet counts in older sickle cell patients may be a consequence of this decreased hematopoietic potential but may also represent a secondary survival benefit effect in sickle cell anemia. Am. J. Hematol. 76:101–106, 2004. © 2004 Wiley‐Liss, Inc.
Three-point correlations in weak lensing surveys: Model predictions and applications

We use the halo model of clustering to compute two- and three-point correlation functions for weak lensing, and apply them in a new statistical technique to measure properties of massive haloes. We present analytical results on the eight shear three-point correlation functions constructed using a combination of the two shear components at each vertex of a triangle. We compare the amplitude and configuration dependence of the functions with ray-tracing simulations and find excellent agreement for different scales and models. These results are promising, since shear statistics are easier to measure than the convergence. In addition, the symmetry properties of the shear three-point functions provide a new and precise way of disentangling the lensing E mode from the B mode due to possible systematic errors. We develop an approach based on correlation functions to measure the properties of galaxy-group and cluster haloes from lensing surveys. Shear correlations on small scales arise from the lensing matter within haloes of mass M ? 10 1 3 M O . Thus, the measurement of two- and three-point correlations can be used to extract information on halo density profiles, primarily the inner slope and halo concentration. We demonstrate the feasibility of such an analysis for forthcoming surveys. We include covariances in the correlation functions due to sample variance and intrinsic ellipticity noise to show that 10 per cent accuracy on profile parameters is achievable with surveys such as the CFHT Legacy survey, and significantly better with future surveys. Our statistical approach is complementary to the standard approach of identifying individual objects in survey data and measuring their properties. It can be extended to perform a combined analysis of the large-scale, perturbative regime down to small, subarcminute scales, to obtain consistent measurements of cosmological parameters and halo properties.
Designing PID Controller For DC Motor System By Means Of Enhanced PSO Algorithm With Discrete Chaotic Lozi Map

The main aim of this paper is the utilization of discrete chaotic Lozi map based chaos number generator to enhance the performance of PSO algorithm. This paper presents the results of research, in whichchaos enhanced PSO algorithm is used to design an optimal PID controller for DC motor system. Obtained results are compared with other non-heuristic and heuristic methods.
Scientific heading: Chemokines PF-4/CXCL4 and CXCL4L1 exhibit distinct subcellular localization and a differentially regulated mechanism of secretion

Prepublished online January 11, 2007; and Paola Romagnani Stefano Netti, Enrico Maggi, Francesco Annunziato, Mario Serio, Sergio Romagnani, Andreas Bikfalvi Francesco Liotta, Francesca Frosali, Elisa Ronconi, Nathalie Alain-Courtois, Lara Ballerini, Giuseppe Laura Lasagni, Renaud Grepin, Benedetta Mazzinghi, Elena Lazzeri, Claudia Meini, Costanza Sagrinati, differentially regulated mechanism of secretion PF-4/CXCL4 and CXCL4L1 exhibit distinct subcellular localization and a