Miracle-dz/UniFAR-FTUs huggingface dataset:
Diuresis and Natriuresis Caused by Activation of VR1-Positive Sensory Nerves in Renal Pelvis of Rats

To test the hypothesis that activation of the vanilloid receptor 1 (VR1) expressed in sensory nerves innervating the renal pelvis leads to diuresis and natriuresis, a selective VR1 receptor agonist, capsaicin (2.4 nmol), or vehicle was perfused intravenously or into the left renal pelvis of anesthetized rats at a rate without changing renal perfusion pressure. Mean arterial pressure was not altered by capsaicin administered intravenously or into the renal pelvis. Capsaicin perfusion into the left renal pelvis but not intravenously caused significant increases in urine flow rate and urinary sodium excretion bilaterally in a dose-dependent manner, which were abolished by capsazepine, a selective VR1 receptor antagonist, given ipsilaterally to the renal pelvis or by ipsilateral renal denervation. Capsaicin given intravenously or into the left renal pelvis increased plasma calcitonin gene–related peptide levels to the same extent. Increased plasma calcitonin gene–related peptide levels induced by capsaicin (68.9±2.8 pg/mL) perfusion into the renal pelvis was prevented either by capsazepine (22.5±10.1 pg/mL) given ipsilaterally into the renal pelvis or by ipsilateral renal denervation (25.9±2.3 pg/mL). Taken together, our data show that unilateral activation of VR1-positive sensory nerves innervating the renal pelvis leads to bilateral diuresis and natriuresis via a mechanism that is independent of plasma calcitonin gene–related peptide levels. These data suggest that VR1-positive sensory nerves in the kidney enhance renal excretory function, a mechanism that may be critically involved in sodium and fluid homeostasis.
The Correspondence between Teacher Questions and Student Answers in Classroom Discourse.

The cognitive thought processes involved in students’ answers to different kinds of teachers’ questions were investigated using data obtained from a previous study. The dimensions examined were (a) the degree of correspondence between the cognitive level of teachers’ questions and the cognitive level of students’ answers, and (b) the relation of that correspondence to the type of cognitive coding system used, grade level, and clarity of the questions and answers. It was found that the chances are about even that there will be a correspondence between the cognitive level of the question asked and the cognitive level of the response that was elicited. The coding system used, grade level of the students, and clarity of the questions each moderated this effect.
Do Immediate Memory Deficits in Students with Learning Disabilities in Reading Reflect a Developmental Lag or Deficit?: A Selective Meta-Analysis of the Literature

The purpose of the present study was to synthesize research that directly compares children with and without learning disabilities in reading on immediate memory performance. Forty-one studies were included in the synthesis, which involved 161 effect sizes. The overall mean effect size estimate in favor of children without learning disabilities in reading was -. 61 (SD=.87). Effect size estimates were submitted to a descriptive and a weighted least-square regression analysis. Results from the full regression model indicated that children with learning disabilities were distinctly disadvantaged compared to average readers when memory manipulations required the naming of visual information and task conditions involved serial recall. Age, IQ, and reading scores were not significant predictors of effect size estimates. Most importantly, nonstrategic (type of task and materials) rather than strategic factors best predicted effect size estimates. The results also indicated that memory difficulties of readers with learning disabilities persisted across age, suggesting that a deficit model best captures the performance of children with learning disabilities. Results are discussed in relation to current developmental models of learning disabilities.
The Effect of the Relative Intensities of Dichotic Messages in Speech Shadowing

Prose messages were presented simultaneously and dichotically to a subject who was required to shadow one of them. Five different relative intensities were used. It is shown that once the two messages are of equal intensity there is little further improvement in shadowing performance if the message the subject accepts is made more intense than the message the subject rejects. Even when the accepted message is −5 db with respect to the rejected message there is no significant rise in errors when the number of mistakes is used as the criterion for assessing the subject's accuracy of response.
Creative Arts Teaching and Practice: Critical Reflections of Primary School Teachers in Australia

This paper details aspects of a research project that explored nineteen Australian primary (elementary) schoolteachers’ perspectives of Creative Arts education. The study investigated the participants’ personal Arts experiences and training, as well as their views of Arts pedagogy. In depth interviews with the participants highlighted the important influence that participants’ own interactions with the various Arts disciplines had upon their role as facilitators of Creative Arts education. The findings of this study also identify multiple ways of approaching and facilitating teaching and learning activities. The research not only revealed insights into the educational value each of the teachers ascribed to individual Arts disciplines, but also the level of confidence and preparedness they felt to teach these disciplines. The generalist primary teachers participating in this research
A recursive frequency-splitting scheme for broadcasting hot videos in VOD service

One way to broadcast a popular/hot video is to let multiple users share a few channels. The stress on the scarce channels can be alleviated without sacrificing viewer waiting time. One common approach is to partition the video into fixed-length segments, which are broadcast on several channels periodically. Two representative approaches are the fast broadcasting scheme and the PAGODA scheme, which can broadcast a video using k channels by having new viewers wait no longer than /spl Theta/(D/2/sup k/) and /spl Theta/(D/5/sup k/2/) time, respectively, where D is the length of the video. In this paper, we propose a new scheme, called recursive frequency splitting (RFS), that significantly improves on existing schemes in terms of viewer waiting time. Some lower bounds on the viewers' waiting time are also developed.
The development of a multi-level model for crisis preparedness and intervention in the Greek educational system

This article proposes a multi-level model for crisis preparedness and intervention in the Greek educational system. It presents: a) a brief overview of leading models of school crisis preparedness and intervention as well as cultural considerations for contextually relevant crisis response; b) a description of existing crisis intervention practices in Greek schools; and c) a model for crisis preparedness and intervention based on specific needs and characteristics of the Greek context. The proposed model consists of several domains including development of a synthetic conceptual framework, education and training, intervention, publications, and collaboration/partnerships. Finally, basic principles that need to be taken into account for the development of a multi-level model with cross-cultural and cross-national considerations regarding crisis preparedness and intervention are discussed.
Urinary podocalyxin as a marker of preeclampsia in a Hispanic population.

BACKGROUND Preeclampsia is associated with significant materno-fetal morbidity and mortality. Podocyturia due to podocyte damage seems to be associated with the disease. The objective of this study was to evaluate the usefulness of urinary podocalyxin as a marker of preeclampsia in a Hispanic population. METHODS 63 patients were studied. 25 patients had preeclampsia/eclampsia (PE-E). 38 patients had normal pregnancies and served as control group. 24 hour proteinuria, urine protein/creatinine (UPC), urinary podocalyxin and perinatal outcomes were measured. A Podocalyxin ELISA test was used to detect podocyturia. RESULTS Mean age (years), mean±SD was 30.5±5.4 in normal patients vs 30.6±5.8 in PE-E, p=0.98. Median gestational age (weeks) was, 38 (range 21-42) for normal pregnancies and 36 (range 24-40) for patients with PE-E, <0.001. Urine podocalyxin/creatinine on admission (ng/mg), median [IQR] in normal patients was 55.9 [29.4, 74.9] vs 109.7 [63.8, 234.1] in PE-E, p=0.001. After adjusting for admission proteinuria, urinary podocalyxin remained independently associated with preeclampsia: OR=1.0040 (95% CI 1.0003-1.0078), p=0.03. There was low to moderate correlation between UPC and urinary podocalyxin, Spearman's =0.31, p=0.01. In PE-E, post-partum urine podocalyxin was lower, median [IQR]: 69.7 [32.7, 184.8] p=0.19 vs admission. There was a trend towards more podocyturia and proteinuria in patients with eclampsia, comparing to those with preeclampsia. There was no association observed between podocyturia and neonatal mortality, IUGR or Apgar scores. CONCLUSIONS Significantly higher levels of urinary podocalyxin are seen in preeclampsia/eclampsia. They tend to normalize after delivery.
On Reflection of Stationary Sets in P Κ Λ

Let κ be an inaccessible cardinal, and let E0 = {x ∈ Pκκ + : cf λx = cf κx} and E1 = {x ∈ Pκκ : κx is regular and λx = κ + x }. It is consistent that the set E1 is stationary and that every stationary subset of E0 reflects at almost every a ∈ E1. Supported by NSF grants DMS-9401275 and DMS 97-04477. Typeset by AMS-TEX 1
Mild/Moderate Behaviorally Disordered Students

The purpose of the present investigation was to examine the language skills of a group of 38 mildly to moderately behavior-disordered students. At issue was whether such students suffer from language disorders as has been reported for Children with more severe behavior disorders such as autism. The results from the Test of Language Development-Intermediate (TOLD-I) (Hammill & Newcomer, 1982) revealed that 37 of the children (97%) fell a minimum of one standard deviation below the normative mean on one or more of the TOLD-I subtests. These findings are offered in support of the notion that the mildly to moderately behavior-disordered child is at risk for language disorders.
Linker Insertion Mutations in the Herpes Simplex Virus Type 1 UL28 Gene: Effects on UL28 Interaction with UL15 and UL33 and Identification of a Second-Site Mutation in the UL15 Gene That Suppresses a Lethal UL28 Mutation

ABSTRACT The UL28 protein of herpes simplex virus type 1 (HSV-1) is one of seven viral proteins required for the cleavage and packaging of viral DNA. Previous results indicated that UL28 interacts with UL15 and UL33 to form a protein complex (terminase) that is presumed to cleave concatemeric DNA into genome lengths. In order to define the functional domains of UL28 that are important for DNA cleavage/packaging, we constructed a series of HSV-1 mutants with linker insertion and nonsense mutations in UL28. Insertions that blocked DNA cleavage and packaging were found to be located in two regions of UL28: the first between amino acids 200 to 400 and the second between amino acids 600 to 740. Insertions located in the N terminus or in a region located between amino acids 400 and 600 did not affect virus replication. Insertions in the carboxyl terminus of the UL28 protein were found to interfere with the interaction of UL28 with UL33. In contrast, all of the UL28 insertion mutants were found to interact with UL15 but the interaction was reduced with mutants that failed to react with UL33. Together, these observations were consistent with previous conclusions that UL15 and UL33 interact directly with UL28 but interact only indirectly with each other. Revertant viruses that formed plaques on Vero cells were detected for one of the lethal UL28 insertion mutants. DNA sequence analysis, in combination with genetic complementation assays, demonstrated that a second-site mutation in the UL15 gene restored the ability of the revertant to cleave and package viral DNA. The isolation of an intergenic suppressor mutant provides direct genetic evidence of an association between the UL28 and UL15 proteins and demonstrates that this association is essential for DNA cleavage and packaging.
The Ability of Psychological Flexibility and Job Control to Predict Learning, Job Performance, and Mental Health

Summary This longitudinal study tested the degree to which an individual characteristic, psychological flexibility, and a work organization variable, job control, predicted ability to learn new skills at work, job performance, and mental health, amongst call center workers in the United Kingdom (N = 448). As hypothesized, results indicated that job control, psychological flexibility, and the synergistic interaction between the two, predicted people's ability to learn a new computer software program, as well as their mental health and job performance, which was objectively measured. Discussion focuses on the implications of these, and previous findings, for organizational behavior.
Ab initio phonon thermal transport in monolayer InSe, GaSe, GaS, and alloys

We compare vibrational properties and phonon thermal conductivities (κ) of monolayer InSe, GaSe, and GaS systems using density functional theory and Peierls–Boltzmann transport methods. In going from InSe to GaSe to GaS, system mass decreases giving both increasing acoustic phonon velocities and decreasing scattering of these heat-carrying modes with optic phonons, ultimately giving κ InSe < κ GaSe < κ GaS . This behavior is demonstrated by correlating the scattering phase space limited by fundamental conservation conditions with mode scattering rates and phonon dispersions for each material. We also show that, unlike flat monolayer systems such as graphene, in InSe, GaSe and GaS thermal transport is governed by in-plane vibrations. Alloying of InSe, GaSe, and GaS systems provides an effective method for modulating their κ through intrinsic vibrational modifications and phonon scattering from mass disorder giving reductions ∼2–3.5 times. This disorder also suppresses phonon mean free paths in the alloy systems compared to those in their crystalline counterparts. This work provides fundamental insights of lattice thermal transport from basic vibrational properties for an interesting set of two-dimensional materials.
Evaluation of the ovine callipyge locus: III. genotypic effects on meat quality traits.

A resource flock of 362 F2 lambs provided phenotypic and genotypic data to estimate effects of callipyge (CLPG) genotypes (NN, NC, CN, and CC) on meat quality traits. The mutant allele is represented as C, the normal allele(s) as N, and the paternal allele of a genotype is given first. Lambs of each genotype born in 1994 and 1995 were serially slaughtered in six groups at 3-wk intervals starting at 23 wk of age. Warner-Bratzler shear force and subjective evaluation of marbling were collected during both years from longissimus. Calpastatin activity was measured on longissimus from the 1994 group, and ELISA quantification of calpastatin protein was obtained from the 1995 group. Significant additive and paternal polar overdominance effects on meat quality traits were detected. This is in contrast to previous research that detected only polar overdominance effects on slaughter and carcass traits in this population. The magnitude of genotypic effects on shear force differed significantly between years; however, additive (P < .01), paternal polar overdominance (P < .001), and maternal dominance (P < .01) effects adjusted for variation in carcass weight were detected within each year. Shear force data adjusted to the mean slaughter age or carcass weight indicated that the means and variances of CN and CC genotypes were greater than values of NC and NN. Shear force values were greatest for CN and were intermediate for CC. The difference in shear force (adjusted for variation in slaughter age) between homozygous genotypes (additive effect) was supported by calpastatin activity data with 2-df F-tests of 3.66 (P < .05) and 11.84 (P < .001) at d 0 and 7 postmortem, respectively. Corresponding values for the paternal polar overdominance effects on calpastatin activity were 53.80 (P < .001) and 87.43 (P < .001). Calpastatin ELISA data (d 0, adjusted for slaughter age) exhibited a paternal polar overdominance effect exclusively with a 2-df F-test of 57.63 (P < .001). Additive and paternal polar overdominance effects on marbling adjusted for slaughter age had F-tests of 6.41 (P < .01) and 93.29 (P < .001), respectively. Consequences of increased longissimus shear force must be addressed if the advantages of CN lambs for dressing percentage and carcass composition are to be realized. Further research is needed to establish whether selection targeted at changing the background genome can mitigate the negative effects of the C allele on meat tenderness.
Current and Potential Uses of Immunocytokines as Cancer Immunotherapy

Immunocytokines (ICs) are a class of molecules created by linking tumor-reactive monoclonal antibodies to cytokines that are able to activate immune cells. Tumor selective localization is provided by the ability of the mAb component to bind to molecules found on the tumor cell surface or molecules found selectively in the tumor microenvronment. In this way the cytokine component of the immunocytokine is selectively localized to sites of tumor and can activate immune cells with appropriate receptors for the cytokine. Immunocytokines have been made and tested by us, and others, using a variety of tumor-reactive mAbs linked to distinct cytokines. To date, the majority of clinical progress has been made with ICs that have linked human interleukin-2 (IL2) to a select number of tumor reactive mAbs that had already been in prior clinical testing as non-modified mAbs (Figure 1). Here we briefly review the background for the creation of ICs, summarize current clinical progress, emphasize mechanisms of action for ICs that are distinct from those of their constituent components, and present some directions for future development and testing.
Crime and reactions to crime in 34 Swedish birth cohorts: from historical descriptions to forecasting the future

This article analyses 34 Swedish birth cohorts with regard to their participation in crime as measured by data from the convictions database maintained by Statistics Sweden. Most existing cohort studies are limited to one or a few cohorts. By contrast, the present study includes 34 cohorts, i.e. all persons born in Sweden between 1958 and 1991. The article discusses methodological problems associated with this type of approach and examines the possibility of making forecasts. The central results are that the number of males with a criminal record has decreased, whereas the number of females has remained fairly stable. Forecasts indicate that the cohorts' participation in crime will continue to decrease. Research and policy implications of the findings are outlined. It is proposed to introduce cohort statistics as a standard branch within regular criminal justice statistics.
The Impact of Student Performance on Large-Scale Assessments: A View of Long-Term Health, Career, and Societal Outcomes

Follow this and additional works at: http://scholarship.shu. edu/dissertations Part of the Applied Statistics Commons, Curriculum and Instruction Commons, Educational Leadership Commons, Educational Psychology Commons, Education Economics Commons, Elementary and Middle and Secondary Education Administration Commons, Secondary Education and Teaching Commons, Social and Philosophical Foundations of Education Commons, Social Statistics Commons, Statistical Methodology Commons, and the Statistical Models Commons
Fructose‐1,6‐bisphosphate aldolase (class II) is the primary site of nickel toxicity in Escherichia coli

Nickel is toxic to all forms of life, but the mechanisms of cell damage are unknown. Indeed, environmentally relevant nickel levels (8 µM) inhibit wild‐type Escherichia coli growth on glucose minimal medium. The same concentration of nickel also inhibits growth on fructose, but not succinate, lactate or glycerol; these results suggest that fructose‐1,6‐bisphosphate aldolase (FbaA) is a target of nickel toxicity. Cells stressed by 8 µM Ni(II) for 20 min lost 75% of their FbaA activity, demonstrating that FbaA is inactivated during nickel stress. Furthermore, overexpression of fbaA restored growth of an rcnA mutant in glucose minimal medium supplemented with 4 µM Ni(II), thus confirming that FbaA is a primary target of nickel toxicity. This class II aldolase has an active site zinc and a non‐catalytic zinc nearby. Purified FbaA lost 80 % of its activity within 2 min when challenged with 8 µM Ni(II). Nickel‐challenged FbaA lost 0.8 zinc and gained 0.8 nickel per inactivated monomer. FbaA mutants (D144A and E174A) affecting the non‐catalytic zinc were resistant to nickel inhibition. These results define the primary site of nickel toxicity in E. coli as the class II aldolase FbaA through binding to the non‐catalytic zinc site.
Aging and the Lateralization of Oscillatory Activities Related to External and Internal Motor Preparation

Selection of action may rely on external guidance or be motivated internally, engaging partially distinct cerebral networks. With age, there is an increased allocation of sensorimotor processing resources, accompanied by a reduced differentiation between the two networks of action selection. The present study examines the age effects on the motor-related oscillatory patterns related to the preparation of externally and internally guided movements. Thirty-two older and 30 younger adults underwent three delayed motor tasks with S1 as preparatory and S2 as imperative cue: Full, laterality instructed by S1 (external guidance); Free, laterality freely selected (internal guidance); None, laterality instructed by S2 (no preparation). Electroencephalogram (EEG) was recorded using 64 surface electrodes. Motor-Related Amplitude Asymmetries (MRAA), indexing the lateralization of oscillatory activities, were analyzed within the S1-S2 interval in the mu (9-12 Hz) and low beta (15-20 Hz) motor-related frequency bands. Reaction times to S2 were slower in older than younger subjects, and slower in the Free than in the Full condition in older subjects only. In the Full condition, there were significant mu MRAA in both age groups, and significant low beta MRAA only in older adults. The Free condition was associated with large mu MRAA in younger adults and limited low beta MRAA in older adults. In younger subjects, the lateralization of mu activity in both Full and Free conditions indicated effective external and internal motor preparation. In older subjects, external motor preparation was associated with lateralization of low beta in addition with mu activity, compatible with an increase of motor-related resources. In contrast, absence of mu and limited low beta lateralization in internal motor preparation was concomitant with reaction time slowing and suggested less efficient cerebral processes subtending free movement selection in older adults, indicating reduced capacity for internally driven action with age.
Situated Learning in Physical Education

In this paper we argue that a version of situated learning theory, as one component of a broader constructivist theory of learning in physical education, can be integrated with other forms of social constructionist research to provide some new ways of thinking about a range of challenges currently facing physical educators, such as the alienation of many young people from physical education. The paper begins with a brief comment on some uses of the term “constructivism” in the physical activity pedagogy literature, then provides a more detailed outline of some of the key tenets of Lave and Wenger’s (1991) theory of situated learning. We then go on to show how this theory of situated learning can be applied to thinking about the social construction of school physical education, using the example of sport education.