Miracle-dz/UniFAR-FTUs huggingface dataset:
Sampled-data feedback stabilization of age-structured chemostat models

We solve a problem of stabilizing an arbitrary equilibrium age profile in an age-structured chemostat. The model is a first-order hyperbolic partial differential equation, with the dilution rate as the control. Our sampled-data feedback ensures stabilization, with arbitrarily sparse sampling. Since the sampling control takes all of its values in a pre-specified bounded interval, we satisfy input constraints. The feedback does not require exact knowledge of the model, nor does it require measurement of the whole age profile.
Can certified health professionals treat obesity in a community-based programme? A quasi-experimental study

Objective To test the effectiveness of a non-pharmaceutical programme for obese participants in a rural Eastern Canadian Province using certified health professionals. Design A prospective quasi-experimental design with repeated premeasure and postmeasure. Participants 146 participants with obesity (body mass index >30 kg/m2) from rural and urban communities in an Eastern Canadian Province were divided into four groups. Intervention A 6-month intensive active community-based lifestyle intervention (InI) delivered by Certified Exercise Physiologists, Certified Personal Trainers and Registered Dietitians, followed by 6 months of self-management. A second intervention (InII) was nested in InI and consisted of group-mediated cognitive–behavioral intervention (GMCBI) delivered by an exercise psychologist to two of the four InI groups. Outcomes (1) Improving health outcomes among the participants’ preactive and postactive 6-month intervention and self-management period, (2) Documenting the impact of InII (GMCBI) and location of the intervention (urban vs rural). Results The 6-month active InI significantly improved cardiovascular health for participants who completed the intervention. InII (GMCBI) significantly lowered the attrition rate among the participants. The self-management period was challenging for the participants and they did not make further gains; however, most were able to maintain the gains achieved during the active intervention. The location of the intervention, urban or rural, had little impact on outcomes. Conclusions A community-based programme utilising healthcare professionals other than physicians to treat obese patients was effective based on premeasure and postmeasure. During the self-management phase, the participants were able to maintain the gains. Psychological support is essential to participant retention.
Sarcoidosis Occurring After Lymphoma

AbstractSarcoidosis is a granulomatous disease that most frequently affects the lungs with pulmonary infiltrates and/or bilateral hilar and mediastinal lymphadenopathy. An association of sarcoidosis and lymphoproliferative disease has previously been reported as the sarcoidosis-lymphoma syndrome. Although this syndrome is characterized by sarcoidosis preceding lymphoma, very few cases of sarcoidosis following lymphoma have been reported. We describe the clinical, biological, and radiological characteristics and outcome of 39 patients presenting with sarcoidosis following lymphoproliferative disease, including 14 previously unreported cases and 25 additional patients, after performing a literature review. Hodgkin lymphoma and non-Hodgkin lymphoma were equally represented. The median delay between lymphoma and sarcoidosis was 18 months. Only 16 patients (41%) required treatment. Sarcoidosis was of mild intensity or self-healing in most cases, and overall clinical response to sarcoidosis was excellent with complete clinical response in 91% of patients. Sarcoidosis was identified after a follow-up computerized tomography scan (CT-scan) or 18fluorodeoxyglucose-positron emission tomography/computerized tomography (18FDG-PET/CT) evaluation in 18/34 patients (53%). Sarcoidosis is therefore a differential diagnosis to consider when lymphoma relapse is suspected on a CT-scan or 18FDG-PET/CT, emphasizing the necessity to rely on histological confirmation of lymphoma relapse.
The mindfulness‐based cognitive therapy adherence scale: inter‐rater reliability, adherence to protocol and treatment distinctiveness

The development of the Mindfulness-Based Cognitive Therapy Adherence Scale (MBCT-AS) is described. This 17-item scale measures therapist adherence to the treatment protocol for Mindfulness-Based Cognitive Therapy (MBCT), a treatment for the prevention of recurrence in Major Depressive Disorder. The MBCT-AS assesses therapist behaviours specific to (MBCT) as well as therapy practices that MBCT shares with Cognitive Behaviour Therapy (CBT). To determine the utility of this scale, we compared delivery of group MBCT against group CBT, with independent ratings of taped sessions provided to measure adherence to MBCT and CBT for therapists in both groups. The results showed that: (a) raters can reliably use the MBCT-AS; (b) MBCT therapists demonstrated adherence to the treatment protocol, as measured by the MBCT-AS; and (c) MBCT is distinguishable from CBT on both the MBCT-AS and a scale measuring adherence to CBT (CBT-AS). These findings indicate that the MBCT-AS may be a useful tool for ensuring the proper delivery of MBCT in future research, and may be helpful in determining the elements of MBCT that are unique to that treatment. Copyright © 2002 John Wiley & Sons, Ltd.
KAJIAN NILAI PENDIDIKAN DALAM KAMUS PERIBAHASA JAWA KARYA F.S. DARMASOETJIPTA

Mulyani . 082160241. Kajian Nilai Pendidikan Peribahasa Jawa Dalam Kamus Peribahasa Jawa Karya F.S. Darmasoetjipta. Skripsi.Pendidikan Bahasa dan Sastra Jawa. Universitas Muhammadiah Purworejo. 2013 Srikpsi yang berjudul Kajian Nilai Pendidikan Peribahasa Jawa Dalam Kamus Peribahasa Jawa Karya F.S. Darmasoetjipta, bertujuan untuk (1) mendeskripsikan jenis-jenis peribahasa yang terdapat dalam Kamus Peribahasa Jawa Karya F.S. Darmasoetjipta, (2) mendeskrisikan nilai pendidikan apa sajakah yangterdapat dalam Kamus Peribahasa Jawa Karya F.S. Darmasoetjipta. Subjeknya adalahmendeskripsikan jenis-jenis peribahasa yang terdapat dalam Kamus Peribahasa Jawa Karya F.S. Darmasoetjipta serta mendeskripsikan jenis-jenis peribahasa yang terdapat dalam Kamus Peribahasa Jawa Karya F.S. Darmasoetjipta, sementara Objek penelitian dalam penelitian ini adalah Kamus Peribahasa Jawa Karya F. S. Darmasoetjipta. Diterbitkan oleh Kanisius, Yogyakarta tahun 1992, dengan jumlah 218 halaman. Teknik pengumpulan data ini digunakan metode observasi dan studi pustaka. Teknik analisis data menggunakan metode analisis isi yang mengkaji isi teks dengan teliti dan menyeluruh.Kemudian penyajian hasil analisisnya menggunakan teknik penyajian hasil analisi informal di mana penyajian hasil analisis menggunakan kata-kata biasa. Hasil analisis dari skripsi ini adalah (1) Dari jumlah seribu peribahasa yang terdapat dalam Kamus Peribahasa Jawa Karya F. S. Darmasoetjipta ini, terdapat 318 paribasan, 466 bebasan, 106 saloka, 20 pepindhan, 3 panyandra. Adapun sisanya tidak dianalisis karena adanya persamaan peribahasa dan terdapat halaman yang hilang; (2) Dibedakan berdasarkan nilai pendidikan yang terdapat dalam Kamus Peribahasa Jawa Karya F. S. Darmasoetjipta, meliputi: nilai pendidikan religius berjumlah 19, nilai pendidikan estetis berjumlah 9, nilai pendidikan ekonomi berjumlah 27, nilai pendidikan politik berjumlah 30, nilai pendidikan teoretis berjumlah 16, dan 827 nilai sosial. Akan tetapi dalam penelitian ini, pembahasan mengenai nilai sosial hanya disajikan berjumlah duapuluh lima, disebabkan karena pembahasan yang kurang lebih sama dan untuk menghemat waktu.
Ehrlichiosis and related infections.

Zoonosis Update T he term ehrlichiosis has been broadly applied to a variety of diseases of humans and animals caused by pathogens formerly classified in the genus Ehrlichia. However, a recently proposed taxonomic reorganization 1 has recommended the reclassifications of some former Ehrlichia species under the genera Anaplasma and Neorickettsia and Cowdria ruminantium under the genus Ehrlichia. 1 Therefore, the term ehrlichiosis is no longer accurately descriptive of the nature of infections caused by these diverse pathogens, but usage of the term persists, and it will be used here for simplicity. The purpose of this review is to summarize pertinent points regarding a few of these pathogens that may infect both humans and animals and are of zoonotic importance in the United States, specifically Anaplasma phagocytophilum (formerly Ehrlichia phagocytophila), E chaffeensis, E ewingii, and E canis (Table 1). Several related pathogens will not be discussed in this review; although E sennetsu causes infections in humans, this pathogen is not found in the United States, and additional pathogens of veterinary interest in the United States such as Neorickettsia risticii (formerly E risticii, the agent of Potomac horse fever or equine monocytic ehrlichiosis), E platys (the agent of canine cyclic throm-bocytopenia), and E bovis are not known to cause infections in humans. Pathogen Characteristics Ehrlichia and Anaplasma species belong to the family Anaplasmataceae. 1 These organisms are small (0.5-to 1.5-µm), gram-negative, pleomorphic, obligate intracel-lular bacteria that reside and replicate in membrane-bound vacuoles of eukaryotic cells. 2 Anaplasma phagocy-tophilum, E chaffeensis, E ewingii, and E canis primarily invade mammalian leukocytes, in which they multiply and form membrane-bound, intracytoplasmic colonies called morulae. 2 The diseases caused by these pathogens have traditionally been categorized by the type of blood cell most commonly infected. For example, E chaffeensis and E canis reside primarily in monocytes, and the disease caused by these agents is frequently called mono-cytic (or monocytotropic) ehrlichiosis. Anaplasma phago-cytophilum and E ewingii reside primarily in granulo-cytes, and the disease caused by these agents is often referred to as granulocytic (or granulocytotropic) ehrli-chiosis. However, some Ehrlichia and Anaplasma species have been found in cells other than their chief target cell type. In addition, more than 1 genus or species may be responsible for monocytic or granulocytic ehrlichiosis. Thus, the traditional cell-based classification scheme is not adequately descriptive of these diseases. The Ehrlichia and Anaplasma species discussed in this review are zoonotic tick-borne pathogens. These agents …
The Actin-Polymerizing Activity of SipA Is Not Essential for Salmonella enterica Serovar Typhimurium-Induced Mucosal Inflammation

ABSTRACT Salmonella enterica serovar Typhimurium depends on type III secretion systems to inject effector proteins into host cells to promote bacterial invasion and to induce intestinal inflammation. SipA, a type III effector, is known to play important roles in both the invasion and the elicitation of intestinal inflammation. The actin-modulating activity of SipA has been shown to promote Salmonella entry into epithelial cells. To investigate whether the actin-modulating activity of SipA is required for its ability to induce an inflammatory response in vivo, we generated the SipAK635A E637W mutant, which is deficient in actin-modulating activity. Salmonella strains expressing the chromosomal SipAK635A E637W point mutation had reduced invasion abilities but still caused colitis similar to that caused by the wild-type strain in a mouse model of infection. Our data indicate that the SipA actin-polymerizing activity is not essential for the SipA-induced inflammatory response in the mouse model of infection.
Gene-Based Single Nucleotide Polymorphisms and Linkage Disequilibrium Patterns of 29 Asthma Candidate Genes in the Chromosome 5q31–33 Region in Koreans

Background and Methods: Numerous genetic studies have mapped asthma susceptibility genes to a region on chromosome 5q31–33 in several populations. This region contains a cluster of cytokines and other immune-related genes important in immune response. In the present study, to determine the genetic variations and patterns of linkage disequilibrium (LD), we resequenced all the exons and promoter regions of the 29 asthma candidate genes in the chromosome 5q31–33 region. Results: We identified a total of 314 genetic variants, including 289 single nucleotide polymorphisms (SNPs), 22 insertion/deletion polymorphisms and 3 microsatellites. Standardized variance data for allele frequency revealed substantial differences in SNP allele frequencies among different ethnic groups. Interestingly, significant ethnic differences were observed mainly in intron SNPs. LD block analysis using 174 common SNPs with a frequency of >10% disclosed strong LD within most candidate genes. No significant LD was observed across genes, except for one LD block (CD14-IK block). Gene-based haplotype analyses showed that 1–5 haplotype-tagging SNPs may be used to define the six or fewer common haplotypes with a frequency of >5%, regardless of the number of SNPs. Conclusion: Overall, our results provide useful information for the identification of immune-mediated disease genes in the chromosome 5q31–33 region, as well as valuable evidence for gene-based haplotype analysis in disease association studies.
Early Performance of Accountable Care Organizations in Medicare.

BACKGROUND In the Medicare Shared Savings Program (MSSP), accountable care organizations (ACOs) have financial incentives to lower spending and improve quality. We used quasi-experimental methods to assess the early performance of MSSP ACOs. METHODS Using Medicare claims from 2009 through 2013 and a difference-in-differences design, we compared changes in spending and in performance on quality measures from before the start of ACO contracts to after the start of the contracts between beneficiaries served by the 220 ACOs entering the MSSP in mid-2012 (2012 ACO cohort) or January 2013 (2013 ACO cohort) and those served by non-ACO providers (control group), with adjustment for geographic area and beneficiary characteristics. We analyzed the 2012 and 2013 ACO cohorts separately because entry time could reflect the capacity of an ACO to achieve savings. We compared ACO savings according to organizational structure, baseline spending, and concurrent ACO contracting with commercial insurers. RESULTS Adjusted Medicare spending and spending trends were similar in the ACO cohorts and the control group during the precontract period. In 2013, the differential change (i.e., the between-group difference in the change from the precontract period) in total adjusted annual spending was -$144 per beneficiary in the 2012 ACO cohort as compared with the control group (P=0.02), consistent with a 1.4% savings, but only -$3 per beneficiary in the 2013 ACO cohort as compared with the control group (P=0.96). Estimated savings were consistently greater in independent primary care groups than in hospital-integrated groups among 2012 and 2013 MSSP entrants (P=0.005 for interaction). MSSP contracts were associated with improved performance on some quality measures and unchanged performance on others. CONCLUSIONS The first full year of MSSP contracts was associated with early reductions in Medicare spending among 2012 entrants but not among 2013 entrants. Savings were greater in independent primary care groups than in hospital-integrated groups.
Image of God and personality pathology: An exploratory study among psychiatric patients

The associations between personality pathology according to DSM-IV, symptomatology and God image were examined among a group of 46 psychiatric patients. Features of personality disorders were assessed using the 'Questionnaire to Assess Personality Pathology', a self-report screener. God image was measured by means of the 'Questionnaire God Image'. Symptomatology was assesed by means of the SCL-90. The more personality pathology present, the more negative the image of God. The negative image of God appeared to be associated with personality pathology, in particular with pathology from the DSM-IV A- and C-cluster, even after controlling for the influence of symptomatology, suggesting that the association between symptomatology and the God image is mediated by personality pathology. When symptoms of the A-cluster are present God is experienced as detached and passive. When C-cluster symptoms prevail, God is experienced as a harsh judge. Results are discussed both from a psychodynamic object-relational as well as from a cognitive schema focused perspective.
Social Studies Education in the Age of Testing and Accountability

With 3 years and counting since its inception, the scope and impact of No Child Left Behind is now being felt in classrooms across the nation. Although some successes have been identified, concerns about the implementation and expectations of the legislation are emerging. As a result of the legislation's emphasis on the development of standards and assessment systems in reading, mathematics, and science, educators of other core and elective subjects are weighing the impact of being left out of the No Child Left Behind formula of testing and accountability. In an attempt to ascertain the perceptions and sentiments of social studies teachers concerning the impact of No Child Left Behind and the concomitant issue of state-level testing and accountability policy, a tristate study was conducted. The findings of this research indicate that although elementary, middle, and high school social studies educators recognize the negative consequences of being left out of No Child Left Behind, they are not convinced that being included would be better for them, their students, or social studies education in general.
CMV INFECTION, CLASS II ANTIGEN EXPRESSION, AND HUMAN KIDNEY ALLOGRAFT REJECTION

After successful transplantation, the major histocom-patibility complex (MHC) antigens of kidney parenchymal cells are lost and no longer detectable in the graft, presumably due to administration of glucocorticosteroids. During rejection, the MHC antigens reappear in the graft parenchymal cells. The upregulation is possibly due to gamma-interferon released in situ by the allograft activated T (blast) cells. In this communication we demonstrate that cytomegalovirus (CMV) infection is invariably associated with an upregulation of the antigen display in the graft. In 12 of 14 (86%) cases with proved CMV disease, the display of class II antigens was associated with a cytological and/or clinical episode of rejection. In 223 transplant recipients without proved CMV disease transplanted during the same period, the frequency of late rejections was 17% (P<0.001). The results suggest that the display of class II antigens on the graft, mediated presumably by gamma-interferon as a consequence of CMV infection, is the reason for graft rejection in context of CMV disease.
Elevated LDH and paranasal sinus involvement are risk factors for central nervous system involvement in patients with peripheral T-cell lymphoma

Background: The incidence and risk factors of central nervous system (CNS) involvement in peripheral T-cell lymphomas (PTCLs) are still unclear. Patients and methods: We analyzed 228 patients with PTCLs, excluding cases of extranodal natural killer/T-cell lymphoma and primary cutaneous T-cell lymphoma, by retrospectively collecting the clinical features and outcomes of the patients. Results: Twenty events (8.77%, 20/228) of CNS involvement were observed during a median follow-up period of 13.9 months (range 0.03–159.43). Based on univariate analysis, elevated serum lactate dehydrogenase (LDH) level [P = 0.019, relative risk (RR) 5.904, 95% confidence interval (CI) 1.334–26.123] and involvement of the paranasal sinus (P = 0.032, RR 3.137, 95% CI 1.105–8.908) adversely affect CNS involvement. In multivariate analysis, both were independently poor prognostic factors for CNS relapse [elevated LDH level: P = 0.011, hazard ratio (HR) 6.716, 95% CI 1.548–29.131; involvement of the paranasal sinus: P = 0.008, HR 3.784, 95% CI 1.420–10.083]. The survival duration of patients with CNS involvement was significantly shorter than that of the patients without CNS involvement (P = 0.009), with median overall survival of 7.60 months (95% CI of 4.92–10.28) versus 27.43 months (95% CI of 0.00–57.38), respectively. Conclusions: Elevated LDH level and involvement of the paranasal sinus are two risk factors for CNS involvement in patients with PTCLs. Considering the poor prognoses after CNS relapse, prophylaxis should be considered with the presence of any risk factor.
Personalized procedural map generation in games via evolutionary algorithms

In digital games, the map (sometimes referred to as the level) is the virtual environment that outlines the boundaries of play, aids in establishing rule systems, and supports the narrative. It also directly influences the challenges that a player will experience and the pace of gameplay, a property that has previously been linked to a player's enjoyment of a game [1]. In most industry leading games, creating maps is a lengthy manual process conducted by highly trained teams of designers. However, for many decades procedural content generation (PCG) techniques have posed as an alternative to provide players with a larger range of experiences than would normally be possible. In recent years, PCG has even been proposed as a means of tailoring game content to meet the preferences and skills of a specific player, in what has been termed Experience-driven PCG (EDPCG) [2].
Reference Frame Activation during Spatial Term Assignment

Abstract Spatial terms such as "above" must be used and interpreted with respect to a frame of reference whose vertical and horizontal axes serve to parse up space. Our interest was in the on-line activation and selection of a reference frame for assigning a direction to "above. " Specifically, we explored whether the alignment of the reference frame′s vertical axis was based on a single source of information (the Single Frame Activation hypothesis) or whether the alignment was selected or calculated on the basis of multiple sources of information (the Multiple Frame Activation hypothesis). In three experiments, we measured response time and acceptance rate for sentences as descriptions of pictures in conditions in which we varied the perceptual cues for verticality in order to test between these hypotheses. Our data suggest that multiple reference frames are active, and they compete during spatial term assignment.
Dual-process theories in social psychology

This informative volume presents the first comprehensive review of research and theory on dual-process models of social information processing. These models distinguish between qualitatively different modes of information processing in making decisions and solving problems (e.g., associative versus rule-based, controlled versus uncontrolled, and affective versus cognitive modes). Leading contributors review the basic assumptions of these approaches and review the ways they have been applied and tested in such areas as attitudes, stereotyping, person perception, memory, and judgment. Also examined are the relationships between different sets of processing modes, the factors that determine their utilization, and how they work in combination to affect responses to social information.
Health care professionals' reactions to working with eating disorder patients

A survey of 71 health care professionals involved in work with eating disorder patients revealed that 20 (28%) of the participants in the survey perceived themselves as moderately to greatly affected by their work with these patients. Among the changes they attributed to their work were an increased awareness of food, their physical condition, their appearance, and feelings about their body. In addition, they reported a positive change in body image and an increased ingestion of healthier foods. The group of health care professionals who perceived themselves as moderately to greatly affected by their work with eating disorder patients was composed approximately equally of normal eaters, binge eaters, and those who reported having experienced eating disorder symptoms at some time in their lives. Length of experience in the field of eating disorders was not a significant factor in being affected or unaffected by work in this area.