Miracle-dz/UniFAR-FTUs huggingface dataset:
Transabdominal Duplex Ultrasonography for Bedside Inferior Vena Cava Filter Placement: Examples, Technique, and Review

Pulmonary embolism remains an endemic challenge for public health care. The first line of treatment for venous thromboembolic disorder has been anticoagulation; however, in the absence of appropriate pharmacologic treatment, because of failure or contraindication, caval filter placement has been widely performed in the prevention of pulmonary embolism. Initially an open surgical procedure, technological advancements have allowed filter placement to be done percutaneously. Bedside filter placement in the intensive care unit with ultrasonographic imaging has been reported to be safe, effective, and reliable. In this report, we present an example, discuss our technique, and review the literature.
Activated factor X signaling via protease-activated receptor 2 suppresses pro-inflammatory cytokine production from lipopolysaccharide-stimulated myeloid cells

Vitamin K-dependent proteases generated in response to vascular injury and infection enable fibrin clot formation, but also trigger distinct immuno-regulatory signaling pathways on myeloid cells. Factor Xa, a protease crucial for blood coagulation, also induces protease-activated, receptor-dependent cell signaling. Factor Xa can bind both monocytes and macrophages, but whether factor Xa-dependent signaling stimulates or suppresses myeloid cell cytokine production in response to Toll-like receptor activation is not known. In this study, exposure to factor Xa significantly impaired pro-inflammatory cytokine production from lipopolysaccharide-treated peripheral blood mononuclear cells, THP-1 monocytic cells and murine macrophages. Furthermore, factor Xa inhibited nuclear factor-kappa B activation in THP-1 reporter cells, requiring phosphatidylinositide 3-kinase activity for its anti-inflammatory effect. Active-site blockade, γ-carboxyglutamic acid domain truncation and a peptide mimic of the factor Xa inter-epidermal growth factor-like region prevented factor Xa inhibition of lipopolysaccharide-induced tumor necrosis factor-α release. In addition, factor Xa anti-inflammatory activity was markedly attenuated by the presence of an antagonist of protease-activated receptor 2, but not protease-activated receptor 1. The key role of protease-activated receptor 2 in eliciting factor Xa-dependent anti-inflammatory signaling on macrophages was further underscored by the inability of factor Xa to mediate inhibition of tumor necrosis factor-α and interleukin-6 release from murine bone marrow-derived protease-activated receptor 2-deficient macrophages. We also show for the first time that, in addition to protease-activated receptor 2, factor Xa requires a receptor-associated protein-sensitive low-density lipoprotein receptor to inhibit lipopolysaccharide-induced cytokine production. Collectively, the findings of this study support a novel function for factor Xa as an endogenous, receptor-associated protein-sensitive, protease-activated receptor 2-dependent regulator of myeloid cell pro-inflammatory cytokine production.
Exploring El Niño mechanisms in climate models

Increasing our understanding of the equatorial Pacific climate phenomenon El Niño – Southern Oscillation (ENSO) is important for making progress in climate prediction and establishing the effects of Global Change on ENSO. The GCMs that are used for IPCC scenarios all show ENSO-like behavior, but the resemblance to the observed ENSO varies from model to model. We wonder whether we can analyse how these differences arise. Which mechanisms are important for ENSO? Are they modelled correctly in climate models? Are models good enough to describe the asymmetry between El Niño and La Niña? Can we say something about El Niño in a future climate? We trace the mechanisms governing El Niño in observations and in a set of 19 coupled global climate models (GCMs). To this end, we use a conceptual model that describes the relations between subsystems that play a role in ENSO using local linear regressions. The first relation describes a wind response to SST variability. The second and third relation describe the response of SST to both thermocline variability and wind stress variability. Finally, a temporal damping on SST is described. We categorize six GCMs as having the most realistic balance of the various feedback mechanisms compared to observations. In four of these models the interannual mode also resembles the observed ENSO both spatially and temporally. In the other 13 models at least one part in the feedback loop between the ocean and atmosphere behaves differently as in observations. We thus selected a subset of best models based on the mechanisms that are important to describe El Niño. For a subset of models as defined above we make projections into a future stable, warmer climate. Although there are large changes in the mean state, the overall ENSO properties do not change much. This is due to the fact that the effects of the changes in the different ENSO relations tend to cancel. In all models, the signs of the changes in ENSO mechanisms are similar. However, the sign of the small net effect differs from model to model. A description in terms of linear couplings leads to symmetry between El Niño and La Niña events. In general, however, El Niño is larger than La Niña. In other words, the distribution of SST anomalies in the East Pacific is positively skewed as a result of nonlinear interactions in the system. Can we use nonlinearities in our conceptual model for analysing what is the likely origin of the skewness of ENSO? What is the role of atmospheric noise in this respect? For observations the linear couplings are extended with a new description of atmospheric noise properties and some nonlinearities in the atmospheric terms. The effect of these nonlinearities are studied with an Intermediate Complexity Model (ICM) in which the fitted couplings and noise properties are implemented, but no further tuning is carried
Fyn Deficiency Promotes a Preferential Increase in Subcutaneous Adipose Tissue Mass and Decreased Visceral Adipose Tissue Inflammation

Previous studies have demonstrated that Fyn knockout (FynKO) mice on a standard chow diet display increased glucose clearance and whole-body insulin sensitivity associated with decreased adiposity resulting from increased fatty acid use and energy expenditure. Surprisingly, however, despite a similar extent of adipose tissue (AT) mass accumulation on a high-fat diet, the FynKO mice remained fully glucose tolerant and insulin sensitive. Physiologic analyses demonstrated that the FynKO mice had a combination of skewed AT expansion into the subcutaneous compartment rather than to the visceral depot, reduced AT inflammation associated with reduced T-cell and macrophage infiltration, and increased proportion of anti-inflammatory M2 macrophages. These data demonstrate that Fyn is an important regulator of whole-body integrative metabolism that coordinates AT expansion, inflammation, and insulin sensitivity in states of nutrient excess. These data further suggest that inhibition of Fyn function may provide a novel target to prevent AT inflammation, insulin resistance, and the dyslipidemia components of the metabolic syndrome.
Inferring textual entailment with a probabilistically sound calculus*

Abstract We introduce a system for textual entailment that is based on a probabilistic model of entailment. The model is defined using a calculus of transformations on dependency trees, which is characterized by the fact that derivations in that calculus preserve the truth only with a certain probability. The calculus is successfully evaluated on the datasets of the PASCAL Challenge on Recognizing Textual Entailment.
Negative Thoughts and Health: Associations Among Rumination, Immunity, and Health Care Utilization in a Young and Elderly Sample

Objective: In the present study, it was tested whether rumination—negative, recurrent thoughts—would be associated with immune parameters and health care utilization. Because rumination has been associated with sadness and subjective sleep quality, it was tested whether these factors mediated the possible effects of rumination. A young sample and an elderly sample were included to test for age differences in the association between rumination and health-related measures. Methods: A representative sample of 196 young subjects (20 to 35 years) and 314 elderly subjects (70 to 85 years) completed questionnaire measures of rumination, sadness, and subjective sleep quality. Immune measures included leukocyte counts, lymphocyte subsets, natural killer cell activity, and T-cell proliferation. Contacts with primary care physicians were registered for 1 year through central registers. Results: Rumination displayed a positive association with total leukocyte count, total lymphocyte count, and number of B cells among the elderly, and this was not mediated by sadness or subjective sleep quality. Rumination was also positively associated with number of telephone consultations during the follow-up for the elderly, and this was partly mediated by sadness and subjective sleep quality. Although total leukocyte counts correlated with number of telephone consultations at the follow-up, none of the immune parameters mediated the association between rumination and health care utilization. No significant associations were found for the young participants. Conclusion: The results suggest that rumination may be associated with health-related measures in the elderly. Thus, negative thoughts may be detrimental to health, independently of negative affect.
Canadian public relations students' interest in government communication: An exploratory study

Purpose - The purpose of this paper is to determine Generation Y communicators' interest in government communications. Design/methodology/approach - This paper outlines the results of a descriptive quantitative survey conducted with 39 students and recent public relations graduates at Calgary, Canada's Mount Royal University. Findings - The results from the small, purposive sample confirm some assumptions employers have about Generation Y and challenge others. The results identify key themes requiring future research. Research limitations/implications - The research is limited in its sample size, but is not meant to be representative. It is a purposive, exploratory study that provides valuable insight into future research. Originality/value - The paper sheds further light on this important topic and fills a gap in the research specific to Generation Y government communicators, offering valuable insight into the recruitment and retention of Generation Y staff in Canadian governments.
Determinants of Internet Mediation:

This article empirically examines if parents apply new types of mediation for the internet, using data from the Dutch EU Kids Online project. The high internet penetration in the Netherlands makes this study especially relevant because almost all parents and children use the internet. Factor analyses applied to reports by parents and children (aged 9–16) revealed four mediation types that are comparable for both groups: active safety mediation, restrictive content mediation, restrictive technical mediation, and monitoring. Demographics (age, gender, education, family size), measures of internet usage, and parental views towards internet use were analysed as determinants of the parental mediation types. Parents monitored younger children in particular, more often actively mediated girls and more often restricted children's internet use in larger families. The use of virtually all mediation types was related to children's diversity in internet use and the parents' view on the benefits of their involvement.
Myocardial ischemic contracture. Metabolites affect rigor tension development and stiffness.

Myocardial ischemia is characterized by a decrease in phosphocreatine (PCr) and Mg(2+)-ATP contents as well as an accumulation of myosin ATPase reaction products (inorganic phosphate [P(i)], protons, and Mg(2+)-ADP). The possibility that these metabolites play a role in rigor tension development was checked in rat ventricular Triton X-100-skinned fibers. Rigor tension was induced by stepwise decreasing [Mg(2+)-ATP] in the presence or in the absence of 12 mmol/L PCr. To mimic the diastolic ionic environment of the myofibrils, [free Ca2+] was set at 100 nmol/L (pCa 7); [free Mg2+], at 1 mmol/L; and ionic strength, at 160 mmol/L. In control conditions (pH 7.1, with no added P(i) or Mg(2+)-ADP), the pMg(2+)-ATP for half-maximal rigor tension (pMg(2+)-ATP50) was 5.07 +/- 0.03 in the presence of PCr. After withdrawal of PCr, the pMg2+)-ATP50 value was shifted toward higher Mg(2+)-ATP values (3.57 +/- 0.03). Addition of 20 mmol/L P(i) shifted the pMg(2+)-ATP50 to 3.71 +/- 0.04 (P < .05) in the absence of PCr and in the opposite direction to 4.98 +/- 0.02 (P < .01) in the presence of PCr. Acidic pH (6.6) strongly increased pMg(2+)-ATP50 in both the absence (3.90 +/- 0.03, P < .001) and presence (5.44 +/- 0.02, P < .001) of PCr. Conversely, Mg(2+)-ADP (250 mumol/L) decreased pMg(2+)-ATP50 to 3.26 +/- 0.06 (P < .001) in the absence of PCr; at pMg(2+)-ATP 4, no rigor tension was observed until PCr concentration was decreased to < 2 mmol/L. At acidic pH, maximal rigor tension was lower by 29% compared with control conditions, whereas in the presence of Mg(2+)-ADP, maximal rigor tension developed to 143% of the control value; P(i) had no effect. The tension-to-stiffness (measured by the quick length-change technique) ratio was lower in rigor (no PCr and pMg(2+)-ATP 6) than during Ca2+ activation in the presence of both PCr and ATP. Compared with control rigor conditions, this parameter was unchanged by Mg(2+)-ADP and decreased by acidic pH, suggesting a proton-induced decrease in the amount of force per crossbridge. In addition to their known effects on active tension, Mg(2+)-ADP and protons affect rigor tension and influence ischemic contracture development. It is concluded that ischemic contracture and increased myocardial stiffness may be mediated by a decreased PCr and local Mg(2+)-ADP accumulation. This emphasizes the importance of myofibrillar creatine kinase activity in preventing ischemic contracture.
Forming a Personal Sense of Identity in the Contemporary World: Challenges and Difficulties

This article considers some normative cultural changes that have contributed to the identity “crises” faced at least by persons living in Western cultures. Identity is conceptualized as a self-structure that provides a frame of reference for processing self-relevant information, answering questions about the meaning and purpose of one’s life, and regulating the processes that individuals use to cope and adapt in everyday life. Individuals living in the modern world characterized by accelerating technological, social, and economic changes face major challenges and problems as they attempt to form and maintain a coherent sense of personal identity. Not all people, however, deal with these identity confl icts in the same fashion. Research reveals reliable differences in how individuals negotiate or manage to avoid the tasks of constructing, maintaining, and reconstructing a sense of identity in the modern world. Three identity processing orientations are highlighted: informational, normative, and diffuse-avoidant. Although an informational processing orientation is associated with resources and skills that maximize adaptability in the modern world, those resources do not provide a set of values or frame of reference for deciding what goals people should commit to or what they should live for. Some of values used to justify identity choices in the modern world are considered.
Antinociceptive and Antioxidant Activities of Phytol In Vivo and In Vitro Models

The objective of the present study was to evaluate the antinociceptive effects of phytol using chemical and thermal models of nociception in mice and to assess its antioxidant effects in vitro. Phytol was administered intraperitoneally (i.p.) to mice at doses of 25, 50, 100, and 200 mg/kg. In the acetic acid-induced writhing test, phytol significantly reduced the number of contortions compared to the control group (P < 0.001). In the formalin test, phytol reduced significantly the amount of time spent in paw licking in both phases (the neurogenic and inflammatory phases), this effect being more pronounced in the second phase (P < 0.001). Phytol also provoked a significant increase in latency in the hot plate test. These antinociceptive effects did not impaire the motor performance, as shown in the rotarod test. Phytol demonstrated a strong antioxidant effect in vitro in its capacity to remove hydroxyl radicals and nitric oxide as well as to prevent the formation of thiobarbituric acid reactive substances (TBARS). Taken as a whole, these results show the pronounced antinociceptive effects of phytol in the nociception models used, both through its central and peripheral actions, but also its antioxidant properties demonstrated in the in vitro methods used.
Full-Cycle Assessment of Critical Thinking in an Ethics and Science Course

Enhancing critical thinking skills for undergraduate students is important across the curriculum and between disciplines. We report on a method of improving critical thinking skills, which was studied through an Ethics and Science First-Year Seminar course. We used full cycle assessment over a three-year period to assess students’ development and to modify the course teaching and assignments with the goal of increasing student development of critical thinking skills. Data were obtained from student writing throughout the semester during each offering. Modest, but significant, overall gains of ~0.7 on a 4 point scale are reported between early and midterm assignments in the course using a seven trait assessment rubric. Key factors that contribute to the increase in critical thinking skills are identified including peer review, scaffolded assignments, and the use of a grading rubric for each assignment.
When Will I See you Again: Modelling the Influence of Social Networks on Social Activities

Social activities account for a large amount of travel, yet due to their irregularity and the number of options regarding location, participants, and timing, they are difficult to model and predict. We assume that social activities are constrained by one’s social network, which consists of people you are close to, both socially and spatially. Therefore, a model of social activity behaviour should be sensitive to the network. In this paper, an agent-based model to describe social activities between two people over time is described and four different input networks (random, based on spatial distance, based on social distance, based on both distances) are experimented with. The results show that the overall social network has an effect on the number of activities generated in the entire system and also between pairs of friends.
Effects of Omega-3 Long Chain Polyunsaturated Fatty Acid Supplementation on Cardiovascular Mortality: The Importance of the Dose of DHA

Recent evidence on the relationship between omega-3 long chain polyunsaturated fatty acid (n-3 LCPUFA) supplementation and cardiovascular health suggests that n-3 LCPUFA may no longer be efficacious. This review summarises the randomised controlled trials (RCTs) that assess the effect of n-3 LCPUFA supplementation on cardiovascular mortality. It appears that in the RCTs that showed no effect of n-3 LCPUFA on cardiovascular mortality, the dose of n-3 LCPUFA (in particular docosahexaenoic acid (DHA)) and hence the n-3 LCPUFA status, may not have been sufficiently high to demonstrate the efficacy, and/or the baseline n-3 LCPUFA status was already too high. The intention-to-treat analysis (ITT) is the gold standard for analysing RCTs and ITT is used for drug intervention trials where exposure to the drug versus no drug exposure provides two clearly distinct groups to determine the efficacy of the drug being studied. This differs in nutrition trials as often the nutrient of interest being studied is already being consumed by both groups (placebo and active) and therefore a true placebo group with absolutely no intake of the nutrient being studied is highly unlikely. Therefore, in n-3 LCPUFA supplementation trials, as there is no clear distinction between the two groups (placebo and n-3 LCPUFA), a per-protocol analysis (comparison of groups that includes only those participants that fully completed the original intervention allocation) should be conducted in addition to ITT analysis. Furthermore, blood analysis pre- and post-supplementation should be conducted to ensure that: (1) that the baseline n-3 status is not too high, in order to alleviate a potential ceiling effect; and (2) that the dose is high enough and hence the increase in omega-3 status will be high enough in order to assess the efficacy of n-3 LCPUFA supplementation.
Prognosis Related to Metastatic Burden Measured by 18F-Fluorocholine PET/CT in Castration-Resistant Prostate Cancer

This study investigated the prognostic significance of metabolically active tumor volume (MATV) measurements applied to 18F-fluorocholine PET/CT in castration-resistant prostate cancer (CRPC). Methods: 18F-fluorocholine PET/CT imaging was performed on 30 patients with CRPC. Metastatic disease was quantified on the basis of maximum standardized uptake value (SUVmax), MATV, and total lesion activity (TLA = MATV × mean standardized uptake value). Tumor burden indices derived from whole-body summation of PET tumor volume measurements (i.e., net MATV and net TLA) were evaluated as variables in Cox regression and Kaplan–Meier survival analyses. Results: Net MATV ranged from 0.12 cm3 to 1,543.9 cm3 (median, 52.6 cm3). Net TLA ranged from 0.40 to 6,688.7 g (median, 225.1 g). Prostate-specific antigen level at the time of PET correlated significantly with net MATV (Pearson r = 0.65, P = 0.0001) and net TLA (r = 0.60, P = 0.0005) but not highest lesional SUVmax of each scan. Survivors were followed for a median 23 mo (range, 6–38 mo). On Cox regression analyses, overall survival had a significant association with net MATV (P = 0.0068), net TLA (P = 0.0072), and highest lesion SUVmax (P = 0.0173) and a borderline association with prostate-specific antigen level (P = 0.0458). Only net MATV and net TLA remained significant in univariate-adjusted survival analyses. Kaplan–Meier analysis demonstrated significant differences in survival between groups stratified by median net MATV (log-rank P = 0.0371), net TLA (log-rank P = 0.0371), and highest lesion SUVmax (log-rank P = 0.0223). Conclusion: Metastatic prostate cancer detected by 18F-fluorocholine PET/CT can be quantified on the basis of volumetric measurements of tumor metabolic activity. The prognostic value of 18F-fluorocholine PET/CT may stem from this capacity to assess whole-body tumor burden. With further clinical validation, 18F-fluorocholine PET-based indices of global disease activity and mortality risk could prove useful in patient-individualized treatment of CRPC.
Inside the College Gates: How Class and Culture Matter in Higher Education

Chapter 1: Inside the College Gates: Education as a Social and Cultural Process Chapter 2: New Student Orientation: How Class and Culture Matter for Settling into College Life Chapter 3: At the Activities Fair: How Class and Culture Matter for Becoming Involved at College Chapter 4: Pulled In or Pushed Out? : How the Organizational Habitus Matters for Working-Class Students' Extra-Curricular Involvement Chapter 5: Ahead of the Class? : The Social Class Worldviews of Upper-Middle-Class Students Chapter 6: Class is in Session: The Social Class Worldviews of Working-Class Students Chapter 7: Lessons Learned: Theoretical and Practical Conclusions