Miracle-dz/UniFAR-FTUs huggingface dataset:
Arabidopsis TAF1 is an MRE11‐interacting protein required for resistance to genotoxic stress and viability of the male gametophyte

Repair of DNA double-strand breaks (DSBs) by recombination pathways is essential for plant growth and fertility. The recombination endonuclease MRE11 plays important roles in sensing and repair of DNA DSBs. Here we demonstrate protein interaction between Arabidopsis MRE11 and the histone acetyltransferase TAF1, a TATA-binding protein Associated Factor (TAF) of the RNA polymerase II transcription initiation factor complex TFIID. Arabidopsis has two TAF1 homologues termed TAF1 and TAF1b and mutant taf1b lines are viable and fertile. In contrast, taf1 null mutations are lethal, demonstrating that TAF1 is an essential gene. Heterozygous taf1+/- plants display abnormal segregation of the mutant allele resulting from defects in pollen tube development, indicating that TAF1 is important for gamete viability. Characterization of an allelic series of taf1 lines revealed that hypomorphic mutants are viable but display developmental defects and reduced plant fertility. Hypersensitivity of taf1 mutants lacking the C-terminal bromodomain to X-rays and mitomycin C, but not to other forms of abiotic stress, established a specific role for TAF1 in plant DNA repair processes. Collectively these studies reveal a function for TAF1 in plant resistance to genotoxic stress, providing further insight into the molecular mechanisms of the DNA damage response in plants.
GENDER AND SOCIAL-CLASS INEQUALITIES IN ACTIVE AGEING: POLICY MEETS THEORY

The concept of active ageing has gained a significant normative importance in European social policy in the XX century, as reflected in the 2012 European Year for Active Ageing and Solidarity between Generations. Despite this growing salience, the issues of possible inequalities in active ageing or in the ability to actively age have received much less attention in the normative discourse and research community. Still, the study of inequalities in the resources needed to lead a fulfilling life such as income, health, education, and social inclusion is of great relevance within the context of the active ageing discourse, as the availability of these resources may profoundly impact on an individual’s ability for well-being and quality of life in old age. In fact, the choices promoted by the active ageing discourse are rarely equally possible for men and women, for highand low-income individuals and for members of socially disadvantaged groups. We aim to reveal these gaps and to show that a country’s high achievement in active aging is not necessarily paralleled and should not be equated with an equal or fair distribution of key resources for successful ageing.
Processing Polarity: How the Ungrammatical Intrudes on the Grammatical

A central question in online human sentence comprehension is, "How are linguistic relations established between different parts of a sentence? " Previous work has shown that this dependency resolution process can be computationally expensive, but the underlying reasons for this are still unclear. This article argues that dependency resolution is mediated by cue-based retrieval, constrained by independently motivated working memory principles defined in a cognitive architecture. To demonstrate this, this article investigates an unusual instance of dependency resolution, the processing of negative and positive polarity items, and confirms a surprising prediction of the cue-based retrieval model: Partial-cue matches-which constitute a kind of similarity-based interference-can give rise to the intrusion of ungrammatical retrieval candidates, leading to both processing slow-downs and even errors of judgment that take the form of illusions of grammaticality in patently ungrammatical structures. A notable achievement is that good quantitative fits are achieved without adjusting the key model parameters.
Time-Dependent and Tissue-Specific Accumulation of mtDNA and Respiratory Chain Defects in Chronic Doxorubicin Cardiomyopathy

Background—Doxorubicin causes a chronic cardiomyopathy of unknown pathogenesis. We investigated whether acquired defects in mitochondrial DNA (mtDNA) and interconnected respiratory chain dysfunction may represent a molecular mechanism for its late onset. Methods and Results—Rats were treated weekly with intravenous doxorubicin (1 mg/kg) for 7 weeks, starting at 11 weeks of age (group B). Controls received saline. Group C received doxorubicin identically to group B, but the course was started at 41 weeks of age. All rats were killed at week 48. Doxorubicin was also injected once, either 6 days (group D) or 2 hours (group E) before euthanasia. Heart and skeletal muscle were examined. Only group B rats developed a significant clinical, macroscopic, histological, and ultrastructural cardiomyopathy. Group B hearts had the lowest cytochrome c oxidase (COX) activity (24% of controls; P =0.003), the highest citrate synthase activity (135% of controls; P =0.005), and the highest production of superoxide. In group B, the respiratory subunit COXI, which is encoded by mtDNA, was reduced (P <0.001), as was mtDNA (49% of controls, P <0.001). Group C hearts differed from group B in their lower cardiomyopathy score (P =0.006), higher COX activity (P =0.02), and higher mtDNA content (P =0.04). Group B and to a lesser extent group C hearts contained deleted mtDNA. There was no detectable mitochondrial toxicity in group D and E hearts or in skeletal muscle. Conclusions—In doxorubicin cardiomyopathy, mtDNA alterations, superoxide, and respiratory chain dysfunction accumulate long-term in the absence of the drug and are associated with a late onset.
Scientific Basis for Swedish Occupational Standards XXI

The labour market, occupational safety and health, and work organisation are our main fields of activity. The creation and use of knowledge through learning, information and documentation are important to the Institute, as is international cooperation. The Institute is collaborating with interested parties in various development projects. The areas in which the Institute is active include: • labour market and labour law, • work organisation, • musculoskeletal disorders, • chemical substances and allergens, noise and electromagnetic fields, • the psychosocial problems and strain-related disorders in modern working life. Preface The Criteria Group of the Swedish National Institute for Working Life (NIWL) has the task of gathering and evaluating data which can be used as a scientific basis for the proposal of occupational exposure limits given by the National Board of Occupational Safety and Health (NBOSH). In most cases a scientific basis is written on request from the NBOSH. The Criteria Group shall not propose a numerical occupational exposure limit value but, as far as possible, give a dose-response/dose-effect relationship and the critical effect of occupational exposure. In searching of the literature several data bases are used, such as RTECS, Toxline, Medline, Cancerlit, Nioshtic and Riskline. Also information in existing criteria documents is used, e.g. documents from WHO, EU, US NIOSH, the Dutch Expert Committee for Occupational Standards (DECOS) and the Nordic Expert Group. In some cases criteria documents are produced within the Criteria Group, often in collaboration with DECOS or US NIOSH. Evaluations are made of all relevant published original papers found in the searches. In some cases information from handbooks and reports from e.g. US NIOSH and US EPA is used. A draft consensus report is written by the secretariat or by a scientist appointed by the secretariat. The author of the draft is indicated under Contents. A qualified evaluation is made of the information in the references. In some cases the information can be omitted if some criteria are not fulfilled. In some cases such information is included in the report but with a comment why the data are not included in the evaluation. After discussion in the Criteria Group the drafts are approved and accepted as a consensus report from the group. They are sent to NBOSH. This is the 21st volume which is published and it contains consensus reports approved by the Criteria Group during the period July 1999 to August 2000. These and previously published …
Computers and the Collaborative Experience of Learning

Until now, the application of computers to educational practice has received little input from psychological theory. This text locates the topic within the contemporary movement of socio-cultural theory, drawing on the writing of Vygotsky and others. It takes an unconventional stance in considering how new technology can enhance rather than undermine the social experience of learning and instruction, and allow teachers to achieve more in the classroom. The author argues that computers can provide the conditions for effective collaboration and enhance the social dimension of education. With its blend of theory and practice, from the primary school to university settings, this study should be of interest to educational psychologists, as well as psychologists studying group processes, cognition and development. It is also aimed at advanced undergraduates and trainee teachers.
İŞKOLİKLİK VE TÜKENMİŞLİK SENDROMU

Bu calismanin temel amaci iskoliklik ile zihinsel, fiziksel ve duygusal tukenmislik arasindaki iliskiyi belirlemektir. Bu amacla Ataturk Universitesi’nde gorev yapan ogretim uyeleri arasindan belirlenen orneklemin iskoliklik ve tukenmislik duzeyleri anket yontemine dayali olarak arastirilmistir. Elde edilen bulgular iskoliklik duzeyindeki artisin zihinsel, fiziksel ve duygusal tukenmisligi artirdigini gostermistir. Ayrica arastirmada, yoneticilik gorevi olan, daha yali olan ve Yardimci Docent unvanina sahip olan ogretim uyelerinin hem iskoliklik hem de tukenmislik duzeylerinin daha yuksek oldugu gozlenmistir. Buna karin cinsiyet, gelir duzeyi ve sigara icme davranisi acisindan ogretim uyelerinin iskoliklik ve tukenmislik duzeyleri arasinda onemli bir farkliliga rastlanmamistir.
Senior Casino Gaming Motivation

Casino gaming is an emerging leisure activity for a s a leisure activity for the senior population. Fin ding out important motivations for older adults spending tim e in casino gaming is the fundamental way to determine their future casino patronage intention. This study ident ifies a comprehensive inventory of senior casino ga ming motivations by way of an exploratory approach. The research also generated a scale development procedure to find five distinctive senior casino gaming motivation di mensions: winning and thrill, socialization, escape , enjoyment, and curiosity. Ultimately, confirmatory factor mode l was parsimonious and captured various dimensions of senior casino gaming motivation.
A New Lumped-Parameter Model of Cerebrospinal Hydrodynamics During the Cardiac Cycle in Healthy Volunteers

Our knowledge of cerebrospinal fluid (CSF) hydrodynamics has been considerably improved with the recent introduction of phase-contrast magnetic resonance imaging (phase-contrast MRI), which can provide CSF and blood flow measurements throughout the cardiac cycle. Key temporal and amplitude parameters can be calculated at different sites to elucidate the role played by the various CSF compartments during vascular brain expansion. Most of the models reported in the literature do not take into account CSF oscillation during the cardiac cycle and its kinetic energy impact on the brain. We propose a new lumped-parameter compartmental model of CSF and blood flows in healthy subjects during the cardiac cycle. The system was divided into five submodels representing arterial blood, venous blood, ventricular CSF, cranial subarachnoid space, and spinal subarachnoid space. These submodels are connected by resistances and compliances. The model developed was used to reproduce certain functional characteristics observed in seven healthy volunteers, such as the distribution (amplitude and phase shift) of arterial, venous, and CSF flows. The results show a good agreement between measured and simulated intracranial CSF and blood flows
Learning Representations for Counterfactual Inference

Observational studies are rising in importance due to the widespread accumulation of data in fields such as healthcare, education, employment and ecology. We consider the task of answering counterfactual questions such as, "Would this patient have lower blood sugar had she received a different medication? ". We propose a new algorithmic framework for counterfactual inference which brings together ideas from domain adaptation and representation learning. In addition to a theoretical justification, we perform an empirical comparison with previous approaches to causal inference from observational data. Our deep learning algorithm significantly outperforms the previous state-of-the-art.
Linguistic Cues to Deception Assessed by Computer Programs: A Meta-Analysis

Research syntheses suggest that verbal cues are more diagnostic of deception than other cues. Recently, to avoid human judgmental biases, researchers have sought to find faster and more reliable methods to perform automatic content analyses of statements. However, diversity of methods and inconsistent findings do not present a clear picture of effectiveness. We integrate and statistically synthesize this literature. Our meta-analyses revealed small, but significant effect-sizes on some linguistic categories. Liars use fewer exclusive words, self- and other-references, fewer time-related, but more space-related, negative and positive emotion words, and more motion verbs or negations than truth-tellers.
Cognitive-behavioral therapies for trauma

Ruzek, Follette, Introduction. Monson, Friedman, Back to the Future of Understanding Trauma: Implications for Cognitive-Behavioral Therapies for Trauma. Part I: Assessment. Follette, Naugle, Functional Analytic Clinical Assessment in Trauma Treatment. Pratt, Brief, Keane, Recent Advances in Psychological Assessment of Adults with Posttraumatic Stress Disorder. Part II: Interventions. Riggs, Cahill, Foa, Prolonged Exposure Treatment of Posttraumatic Stress Disorder. Shipherd, Street, Resick, Cognitive Therapy for Posttraumatic Stress Disorder. Wagner, Linehan, Applications of Dialectical Behavior Therapy to Posttraumatic Stress Disorder and Related Problems. Walser, Hayes, Acceptance and Commitment Therapy in the Treatment of Posttraumatic Stress Disorder: Theoretical and Applied Issues. B. Kohlenberg, Tsai, R. Kohlenberg, Functional Analytic Psychotherapy and the Treatment of Complex Posttraumatic Stress Disorder. Part III: Specialized Populations and Delivery Considerations. Bryant, Cognitive-Behavioral Therapy for Acute Stress Disorder. Najavits, Seeking Safety: Therapy for Posttraumatic Stress Disorder and Substance Use Disorder. Kubany, Ralston, Cognitive Therapy for Trauma-related Guilt and Shame. Shear, Frank, Treatment of Complicated Grief: Integrating Cognitive-Behavioral Methods with Other Treatment Approaches. Cloitre, Rosenberg, Sexual Revictimization: Risk Factors and Prevention. Leonard, Follette, Compton, A Principle-based Intervention for Couples Affected by Trauma. Foy, Larson, Group Therapies for Trauma Using Cognitive-Behavioral Therapy. Deblinger, Thakkar-Kolar, Ryan, Trauma in Childhood. Ruzek, Bringing Cognitive-Behavioral Psychology to Bear on Early Intervention with Trauma Survivors: Accident, Assault, War, Disaster, Mass Violence, and Terrorism.
Strategic Orientations and Organisational Types: A Theoretical Link

The aim of this study is to explore the extant literature with respect to the effect of organisational types on SO-performance relationship. The type of an organisation is a mental model or metaphorical representation manifested through the structural characteristics such as systems, processes, nature of business and workforce. It is also manifested through values, norms, shared vision (known as culture) and strategic orientations. Authors of this study therefore firmly believe and propose a significant connection between type of organization and SO-performance relationship. The paper discusses this conceptual link through the review of literature systematically based on last three years research publications i.e. 2010-2012. Firstly, authors highlight the existence of SO-performance relationships and then purport the links between frequently cited SOs and organisational types. The study concludes with several propositions based on a theoretical framework and provokes attention of future researchers towards this crucial issue.
A Level Set Formulation of Eulerian Interface Capturing Methods for Incompressible Fluid Flows

A level set formulation is derived for incompressible, immiscible Navier? Stokes equations separated by a free surface. The interface is identified as the zero level set of a smooth function. Eulerian finite difference methods based on this level set formulation are proposed. These methods are robust and efficient and are capable of computing interface singularities such as merging and reconnection. Numerical experiments are presented to demonstrate the effectiveness of the methods.
Development and adult phase plasticity of syllable repetitions in the birdsong of captive zebra finches (Taeniopygia guttata).

Oscines learn their birdsongs from tutors. The authors found that a small fraction (approximately 7%) of captive male zebra finches (Taeniopygia guttata) produce variant acoustic birdsong profiles consisting of repetitions of single song syllables at high frequencies. Juvenile offspring of nonrepeaters can selectively learn the syntactic rule or habit of repeating syllables from repeaters. Adult tutored syllable repeaters, unlike spontaneous repeaters, undergo a form of song plasticity involving progressive reduction of the mean number and variance of repeated syllables as a function of long-term exposure to nonrepeater songs without altering the number or sequence of syllables within motifs. These findings suggest that aspects of song syntax or temporal frame can be acquired independently of song syllable or spectral content, and plasticity involving restorative alteration of acquired variant temporal frames can occur after the closure of the critical period for song learning.
Neurodevelopment: The Impact of Nutrition and Inflammation During Infancy in Low-Resource Settings

Infancy and early childhood (ie, birth through age 24 months) represent a period of life with both exquisite opportunity and vulnerability for neurodevelopment. This is due to rapid brain development, both anatomic and functional, as well as to high nutrient requirements during a time of dependence on human milk and complementary foods. Complex interactions exist among nutrition, social, and physical environments and exposures. The newborn brain also reflects maternal exposures that occurred as the product of many interacting forces during gestation. Connections between nutrient use and acute and chronic inflammation are increasingly recognized, but the evidence base linking both nutrition and inflammation to neurodevelopment is relatively modest and quite limited for this young age group specifically. This article provides an overview of key interactions of nutritional requirements relevant to brain development and function; nutritional vulnerabilities related to maternal nutritional status and function; and the impact of environmental exposures and inflammation on nutrient homeostasis and neurodevelopment during this critical developmental window.
Pathogenesis of West Nile Virus Infection: a Balance between Virulence, Innate and Adaptive Immunity, and Viral Evasion

West Nile virus (WNV) is a neurotropic flavivirus that has emerged globally as a significant cause of viral encephalitis. WNV is maintained in an enzootic cycle between mosquitoes and birds (reviewed in reference [75][1]) but can also infect and cause disease in horses and other vertebrate animals.
Beyond Public vs. Private: The Transformative Potential of Democratic Feminist Management

The transformative potential of public administration is forestalled by the portrayal of management as sphere-specific or apolitical and the resultant portrayal of marginality as natural. The lived experiences of people at the organizational level and beyond deny the objectivity of separating public and private management and thus, through the exposure of the politics of management, open a space for discussion of the transformative potential of public administration. This paper suggests a more holistic "management"1 approach, built on the ideas of feminist and democratic theories and the praxis of Mary Parker Follett, Jane Addams, and more contemporary feminist theories of management. We conclude that a democratic feminist theory of management is potentially transformative in its recognition of the conditions under which all forms of marginalization are sustained and the discovery of the potential to change them.
Racial Differences in Psychotic-like Experiences: A Study of Schizotypy in African Americans and Caucasians

Title of dissertation: RACIAL DIFFERENCES IN PSYCHOTIC-LIKE EXPERIENCES: A STUDY OF SCHIZOTYPY IN AFRICAN-AMERICANS AND CAUCASIANS Kimberly Anne Adams, Doctor of Philosophy, 2007 Dissertation directed by: Professor Jack J. Blanchard Department of Psychology A considerable literature has long indicated that African Americans consistently receive more clinical diagnoses of psychosis than their Caucasian counterparts although higher rates of schizophrenia in African Americans have not been reliably documented. Prior studies are limited in that while many have found elevations in psychotic symptoms and schizophrenia diagnoses in African Americans patients, it is unclear whether these race differences indicate true rates of psychosis or whether other mechanisms such as lowered medication compliance and limited access to treatment might be complicating these findings. Further, comparisons between racial groups in studies of psychosisproneness have focused primarily on mean group differences in overall psychotic symptoms. While helpful in establishing the existence of symptom differences in racial groups, these finding do not provide more qualitative information regarding the specific nature of these differences. It can therefore be suggested that a comprehensive understanding of the role of race in schizophrenia remains elusive. The goal of the current study was to extend the available research on race differences in the experience of psychotic-like experiences by addressing the following hypotheses in a sample of putative schizotypes (social anhedonics): 1) Social anhedonics will report more psychotic-like symptoms and experiences than controls, regardless of race, 2) Psychotic-like experiences will be more prevalent in socially anhedonic African Americans compared to socially anhedonic Caucasians, and 3) socially anhedonic African Americans will report more psychotic-like experiences with religious and paranoid themes than socially anhedonic Caucasians. Possible reasons for differential symptom expression will be explored, followed by assessment and treatment implications. Finally, suggestions for future directions of study will be discussed. RACIAL DIFFERENCES IN PSYCHOTIC-LIKE EXPERIENCES: A STUDY OF SCHIZOTYPY IN AFRICAN-AMERICANS AND CAUCASIANS