Miracle-dz/UniFAR-FTUs huggingface dataset:
In vivo investigation into the effects of haemodilution with hydroxyethyl starch (200/0.5) and normal saline on coagulation.

We have investigated the effects of haemodilution with either saline or hydroxyethyl starch (200/0.5) (HES) on blood coagulation in healthy volunteers in vivo. Standard haematological tests (packed cell volume (PCV), platelets, prothrombin time (PT), activated partial thromboplastin time (aPTT), fibrinogen, antithrombin III, bleeding time and platelet aggregation), and thrombelastography (TEG) were performed before and after administration of either 0.9% saline 1000 ml or HES 1000 ml i.v. over a 30-min period. Dilution of PCV and platelet concentrations as a result of volume load were 9% in the saline group and 19% in the HES group. Reductions in fibrinogen (18.6% and 28.8%) and antithrombin III (25.5% and 37.8%) were significantly greater than could be explained by haemodilution alone in both groups. Indices of platelet aggregation were significantly enhanced by saline haemodilution, but not by HES, which inhibited epinephrine-induced aggregation and prolonged bleeding time. TEG in the saline group showed significantly shortened r and k times (24% and 26%, respectively), and increased alpha angle (24%) and maximum amplitude (MA, 6%). HES haemodilution decreased MA (11%) but did not affect other TEG variables. We conclude that haemodilution of normal blood exerted a procoagulant effect, possibly by enhancement of thrombin formation. Circulating concentrations of antithrombin III were depleted more than could be explained by haemodilution alone, leading to a hypercoagulable state. This effect was offset by an antiplatelet action of HES, which was not seen with saline. The mechanism is unknown.
Pharmacokinetics and therapeutic efficacy of imipenem, ceftazidime, and ceftriaxone in experimental meningitis due to an ampicillin- and chloramphenicol-resistant strain of Haemophilus influenzae type b

The pharmacokinetics and therapeutic efficacy of imipenem, ceftazidime, and ceftriaxone were compared with those of ampicillin and chloramphenicol in rabbits with experimental meningitis due to an ampicillin- and chloramphenicol-resistant strain of Haemophilus influenzae type b. The mean bacterial colony counts in cerebrospinal fluid were reduced by 49% (-1.85 log10 CFU/ml), 92% (-3.37 log10 CFU/ml), and 92% (-4.30 log10 CFU/ml) after a single dose of imipenem, ceftazidime, and ceftriaxone, respectively. The median peak cerebrospinal fluid bactericidal titers against this multiply resistant strain of H. influenzae were 1:4 for thienamycin, 1:16 for ceftazidime, and 1:256 for ceftriaxone. By contrast, no bactericidal activity was observed in cerebrospinal fluid and the mean concentrations of H. influenzae were either unchanged or slightly increased in animals treated with ampicillin or chloramphenicol.
In vitro Intestinal Mucosal Epithelial Responses to Wild-Type Salmonella Typhi and Attenuated Typhoid Vaccines

Typhoid fever, caused by S. Typhi, is responsible for approximately 200,000 deaths per year worldwide. Little information is available regarding epithelium-bacterial interactions in S. Typhi infection. We have evaluated in vitro the effects of wild-type S. Typhi, the licensed Ty21a typhoid vaccine and the leading strains CVD 908-htrA and CVD 909 vaccine candidates on intestinal barrier function and immune response. Caco2 monolayers infected with wild-type S. Typhi exhibited alterations in the organization of tight junctions, increased paracellular permeability, and a rapid decrease in Trans-Epithelial Electrical Resistance as early as 4 h post-exposure. S. Typhi triggered the secretion of interleukin (IL)-8 and IL-6. Caco2 cells infected with the attenuated strains exhibited a milder pro-inflammatory response with minimal disruption of the barrier integrity. We conclude that wild-type S. Typhi causes marked transient alterations of the intestinal mucosa that are more pronounced than those observed with Ty21a or new generation attenuated typhoid vaccine candidates.
Anesthetic review of emergency peripartum hysterectomy following vaginal and cesarean delivery: a retrospective study

Background The purpose of this study was to review incidence, indications, complications, and the anesthetic management of emergency obstetric hysterectomies. Methods This was a retrospective study of the cases of emergency obstetric hysterectomies performed at the Woman's Hospital over a 3 year period between January 2008 and December 2010. The indication for surgery, anesthetic management, operating time, estimated blood loss, pre- and postoperative hemoglobin and hematocrit values, need for blood transfusion, and perioperative complications were obtained. Results During the study period there were 46 emergency obstetric hysterectomies for 20147 deliveries, giving an incidence of 2.28/1000 deliveries. The number of emergency hysterectomies was significantly higher with the cesarean deliveries than with the vaginal deliveries. The most common indication for emergency obstetric hysterectomy was placenta accreta. Postoperatively, Dissemimated Intravascular Coagulation (DIC) was the most common complication. Conclusions Abnormal placenta has been an main indication of emergency hysterectomy. Anesthesiologists should be eligible to aware of high risk of emergency hysterectomy and deal with massive hemorrhage.
Radiolabeled fragments of monoclonal antibodies against carcinoembryonic antigen for localization of human colon carcinoma grafted into nude mice

Four monoclonal antibodies against carcinoembryonic antigen (CEA) have been selected from 32 hybrids that produce antibodies against this antigen, by the criteria of high affinity for CEA and low cross- reactivity with granulocyte glycoprotein(s). The specificity of tumor localization in vivo of the four MAb, and their F(ab')2 and Fab fragments was compared in nude mice bearing grafts of a serially transplanted, CEA-producing, human colon carcinoma. The distribution of radiolabeled MAb and their fragments after intravenous injection was analyzed by direct measurement of radioactivity in tumor and normal organs, as well as by whole-body scanning and by autoradiography of tumor sections. Paired labeling experiments, in which 131I-labeled antibody or fragments and 125I-labeled control IgG are injected simultaneously, were undertaken to determine the relative tumor uptakes of each labeled protein. The tumor antibody uptake divided by that of control IgG defines the specificity index of localization. Tumor antibody uptakes (as compared with the whole mouse), ranging between 7 and 15, and specificity indices ranging between 3.4 and 6.8, were obtained with the four intact MAb at day 4-5 after injection. With F(ab')2 fragments of the four MAb, at day 3, the tumor antibody uptakes ranged between 12 and 24 and the specificity indices between 5.3 and 8.2. With the Fab fragments prepared from the two most promising MAb, the antibody uptakes reached values of 34 and 82 at day 2-3 and the specificity indices were as high as 12 and 19. The scanning results paralleled those obtained by direct measurement of radioactivity. With intact MAb, tumor grafts of 0.5-1 g gave very contrasted positive scans 3 d after injection. Using MAb fragments, tumors of smaller size were detectable earlier. The best results were obtained with Fab fragments of MAb 35, which gave clear detections of tumors weighing only 0.1 g as early as 48 h after injection. Autoradiographs of tumor sections from mice injected with 125I-labeled MAb demonstrated that the radioactivity was localized in the tumor tissues and not in the stromal connective tissue of mouse origin. The highest radioactivity concentration was localized in areas known to contain CEA such as the pseudolumen of glands and the apical side of carcinoma cells. The penetration of radioactivity in the central part of tumor nodules and the pseudolumen appeared to be increased with the use of MAb fragments.
Filtering Based Adaptive Visual Odometry Sensor Framework Robust to Blurred Images

Visual odometry (VO) estimation from blurred image is a challenging problem in practical robot applications, and the blurred images will severely reduce the estimation accuracy of the VO. In this paper, we address the problem of visual odometry estimation from blurred images, and present an adaptive visual odometry estimation framework robust to blurred images. Our approach employs an objective measure of images, named small image gradient distribution (SIGD), to evaluate the blurring degree of the image, then an adaptive blurred image classification algorithm is proposed to recognize the blurred images, finally we propose an anti-blurred key-frame selection algorithm to enable the VO robust to blurred images. We also carried out varied comparable experiments to evaluate the performance of the VO algorithms with our anti-blur framework under varied blurred images, and the experimental results show that our approach can achieve superior performance comparing to the state-of-the-art methods under the condition with blurred images while not increasing too much computation cost to the original VO algorithms.
Cornea CTG 18 . 1 Expansion in TCF 4 Among African Americans With Fuchs ’ Corneal Dystrophy

Citation: Eghrari AO, Vahedi S, Afshari NA, Riazuddin SA, Gottsch JD. CTG18.1 expansion in TCF4 among African Americans with Fuchs’ corneal dystrophy. Invest Ophthalmol Vis Sci. 2017;58:6046–6049. DOI: 10.1167/iovs.17-21661 PURPOSE. Studies of Fuchs’ dystrophy have largely focused on individuals of European origin. Characterization of disease among African Americans is required to ensure prognostic factors and therapeutic approaches are applicable across diverse patient populations.
Phenotyping primary human microglia: Tight regulation of LPS responsiveness

Much is still unknown about mechanisms underlying the phenotypical and functional versatility of human microglia. Therefore, we developed a rapid procedure to isolate pure microglia from postmortem human brain tissue and studied their immediate ex vivo phenotype and responses to key inflammatory mediators. Microglia were isolated, along with macrophages from the choroid plexus by tissue dissociation, density gradient separation, and selection with magnetic microbeads. By flow cytometry, microglia were identified by a CD11b+CD45dim phenotype and a smaller size compared with CD11b+CD45high macrophages. Interestingly, white matter microglia from donors with peripheral inflammation displayed elevated CD45 levels and increased size and granularity, but were still distinct from macrophages. The phenotype of isolated microglia was further specified by absent surface expression of CD14, CD200 receptor, and mannose receptor (MR, CD206), all of which were markedly expressed by macrophages. Microglia stimulated immediately after isolation with LPS and IFNγ failed to upregulate TNFα or CCR7. Notably, responsiveness to LPS and IFNγ was clearly instigated in microglia after overnight preculture, which coincided with a strong upregulation of CD14. Culture of microglia with IL‐4 resulted in the induction of HLA‐DR and CCL18 but not MR, whereas culture with dexamethasone did induce MR, in addition to CD163 and CCL18. In conclusion, this study demonstrates phenotypic changes of microglia associated with peripheral inflammation, and reveals tight regulation of responses to LPS and IFNγ as well as distinct microglial responses to IL‐4 and glucocorticoids. These findings are of high relevance to studies on human microglia functioning in health and disease. © 2012 Wiley Periodicals, Inc.
Relationship between airway ion transport and a mild pulmonary disease mutation in CFTR.

Patients with cystic fibrosis (CF) display defects in airway ion transport, but the influence of airway transport phenotype on improved prognosis is not known. We studied airway bioelectric properties in five CF patients with the rare A455E mutation that is associated with mild pulmonary disease. We also evaluated five patients possessing premature truncation mutations (G542X and R553X) for which an association with mild pulmonary disease has not been as well established. We found no evidence in vivo that a mild lung disease mutation in the CF transmembrane regulator gene (CFTR) led to correction or partial correction of: (1) unstimulated Cl- secretion; (2) beta-agonist-activated Cl- secretion; (3) basal sodium reabsorption; or (4) amiloride-sensitive airway sodium transport. Early phase therapeutic trials in CF, including human gene transfer trials, rely heavily on improvements in airway potential difference to identify promising interventions and an improved prognosis. Based on our findings in a naturally occurring group of CF patients with an improved pulmonary prognosis (A455E), one can argue that marked clinical benefit might be possible without any improvement whatsoever in airway bioelectric phenotype. Moreover, if genetic modifiers exist that influence the severity of a particular CFTR mutation (e.g., A455E), these may be independent of human airway Cl-secretion in vivo, since we detected minimal Cl--secretory responses in patients with A455E.
Ataxia telangiectasia mutated impacts insulin‐like growth factor 1 signalling in skeletal muscle

• What is the central question of this study? In some cultured cells, ataxia telangiectasia mutated (ATM) is required for activation of Akt by insulin. However, this is not the case in other cell or tissue types, including skeletal muscle. Furthermore, it is not known whether ATM plays a role in skeletal muscle insulin‐like growth factor 1 (IGF‐1) signalling. • What is the main finding and its importance? We found that IGF‐1 caused autophosphorylation of ATM in skeletal muscle. However, IGF‐1‐stimulated phosphorylation of Akt, p70 S6 kinase and mammalian target of rapamycin (but not insulin receptor substrate 1) was impaired in C2C12 myotubes with reduced ATM expression and/or muscle from ATM‐haploinsufficient mice. These findings demonstrate activation of ATM by IGF‐1 and a role for ATM in IGF‐1 signalling downstream of insulin receptor substrate 1.
A large-scale Shape Benchmark for 3D object retrieval: Toyohashi shape benchmark

In this paper, we describe the Toyohashi Shape Benchmark (TSB), a publicly available new database of polygonal models collected from the World Wide Web, consisting of 10,000 models, as the largest 3D shape models to our knowledge used for benchmark testing. TSB includes 352 categories with labels. It can be used for both 3D shape retrieval and 3D shape classification. Until now, the most well-known 3D shape benchmark has been the PSB, or the Princeton Shape Benchmark, consisting of 1,814 models, including the half as training data and the remaining half as testing. The TSB is approximately 6 times larger than the PSB. Unlike textual data such as TREC and NTCIR data collections, 3D shape repositories have been suffering from the shortage of data, and from the difficulty in testing the scalability of any algorithms that work on top of given benchmark data set. In addition to the TSB, we propose a new shape descriptor which we call DB-VLAT (Depth-Buffered Vector of Locally Aggregated Tensors). During the comparison with the TSB, we will demonstrate that our new shape descriptor exhibits the best search performance among those known programs to which we have had access on the Internet, including the Spherical Harmonic Descriptor and Light-Field Descriptor. We consider that the TSB can be a step toward the next generation 3D shape benchmark having massive 3D data collection, and hope it will serve for many purposes in both academia and industry.
Odor discrimination in neural populations Molecular features of odorants systematically influence slow temporal responses across clusters of coordinated antennal lobe units in the moth Manduca sexta

This work was supported by an award from NIH-NCRR (9 R01 RR14166) to BHS & NIH-NIDCD (1 R03 DC05535) to KCD. Initial support was provided by a contract from DARPA/CBS to J.G. Hildebrand. The authors also wish to thank the University of Michigan Center for Neural Communication Technology (NIH/NCRR grant P41 RR09754) for electrode supply. We would also like to thank T.A. Christensen, H. Lei, L. P. Tolbert, A. , Dacks, & G. L. Gerstein for their comments on this work.
Identification of Widespread Ultra-Edited Human RNAs

Adenosine-to-inosine modification of RNA molecules (A-to-I RNA editing) is an important mechanism that increases transciptome diversity. It occurs when a genomically encoded adenosine (A) is converted to an inosine (I) by ADAR proteins. Sequencing reactions read inosine as guanosine (G); therefore, current methods to detect A-to-I editing sites align RNA sequences to their corresponding DNA regions and identify A-to-G mismatches. However, such methods perform poorly on RNAs that underwent extensive editing (“ultra”-editing), as the large number of mismatches obscures the genomic origin of these RNAs. Therefore, only a few anecdotal ultra-edited RNAs have been discovered so far. Here we introduce and apply a novel computational method to identify ultra-edited RNAs. We detected 760 ESTs containing 15,646 editing sites (more than 20 sites per EST, on average), of which 13,668 are novel. Ultra-edited RNAs exhibit the known sequence motif of ADARs and tend to localize in sense strand Alu elements. Compared to sites of mild editing, ultra-editing occurs primarily in Alu-rich regions, where potential base pairing with neighboring, inverted Alus creates particularly long double-stranded RNA structures. Ultra-editing sites are underrepresented in old Alu subfamilies, tend to be non-conserved, and avoid exons, suggesting that ultra-editing is usually deleterious. A possible biological function of ultra-editing could be mediated by non-canonical splicing and cleavage of the RNA near the editing sites.
Parental bonding and depressive disorders in adolescents.

The present exploratory study was designed to determine whether a sample of depressed adolescents differed from demographically similar samples of normal and non-depressed psychiatric controls as a function of their perceived patterns of parental bonding. All research participants were recruited from the general population. Diagnoses were based on a structured diagnostic interview keyed to DSM-III criteria. Parental bonding was assessed using the Parental Bonding Instrument [PBI; Parker, G. Tupling, H. & Brown, L.B. (1979). A parental bonding instrument. British Journal of Medical Psychology, 52, 1-10]. The results of this study suggest that parental bonding plays an important but non-specific role in the occurrence of adolescent psychopathology.
A Study of the Hand-Hold Impact on the EM Interaction of a Cellular Handset and a Human

This paper investigates the impact of the hand-hold positions on both antenna performance and the specific absorption rate (SAR) induced in the user’s head. A cellular handset with external antenna operating at GSM-900 frequency is modeled and simulated using a finite difference time-domain (FDTD)-based platform SEMCAD-X. A specific anthropomorphic mannequin (SAM) is adopted to simulate the user’s head, whereas a semirealistic CAD-model of three-tissues is designed to simulate the user’s hand. The results show that in case of the handset in hand close to head at different positions; the antenna total efficiency gets reduced to (14.5% 5.9%) at cheek-position and to (27.5% to 11.8%) at tilt-position. The peak averaged SAR1g values in head close to handset without hand, are 4.67 W/Kg and 2.66 W/Kg at cheek and tilt-position, respectively. Due to the presence of hand, the SAR1g in head gets reduced to (3.67-3.31 W/Kg) at cheek-position and to (1.84-1.64 W/Kg) at tilt-position, depending on the hand-hold position. Keywords—FDTD, phantom, specific absorption rate (SAR), cellular handset exposure.
Co–Residence between Males and Their Mothers and Grandmothers Is More Frequent in Bonobos Than Chimpanzees

In long–lived social mammals such as primates, individuals can benefit from social bonds with close kin, including their mothers. In the patrilocal chimpanzee (Pan troglodytes spp.) and bonobo (Pan paniscus), sexually mature males reside and reproduce in their natal groups and can retain post-dependency bonds with their mothers, while immatures of both sexes might also have their paternal grandmothers available. However, quantitative information on the proportion of males and immatures that co-reside with both types of these close female relatives is limited for both species. Combining genetic parentage determination and group composition data from five communities of wild chimpanzees and three communities of wild bonobos, we estimated the frequency of co-residence between (1) mature males and their mothers, and (2) immature males and females and their paternal grandmothers. We found that adult males resided twice as frequently with their mothers in bonobos than in chimpanzees, and that immature bonobos were three times more likely to possess a living paternal grandmother than were immature chimpanzees. Patterns of female and male survivorship from studbook records of captive individuals of both species suggest that mature bonobo females survive longer than their chimpanzee counterparts, possibly contributing to the differences observed in mother–son and grandmother–immature co-residency levels. Taking into account reports of bonobo mothers supporting their sons' mating efforts and females sharing food with immatures other than their own offspring, our findings suggest that life history traits may facilitate maternal and grandmaternal support more in bonobos than in chimpanzees.
Adaptive proportional routing: a localized QoS routing approach

Most of the QoS routing schemes proposed so far require periodic exchange of QoS state information among routers, imposing both communication overhead on the network and processing overhead on core routers. Furthermore, stale QoS state information causes the performance of these QoS routing schemes to degrade drastically. In order to circumvent these problems, we focus on localized QoS routing schemes where the edge routers make routing decisions using only "local" information and thus reducing the overhead at core routers. We first describe virtual capacity-based routing (VCR), a theoretical scheme based on the notion of virtual capacity of a route. We then propose proportional sticky routing (PSR), an easily realizable approximation of VCR and analyze its performance. We demonstrate through extensive simulations that adaptive proportional routing is indeed a viable alternative to the global QoS routing approach.
Cache Invalidation and Propagation in Distributed caching

Replication and caching strategies are increasingly being used to improve performance and reduce user perceived delays in distributed environments. A query can be answered much faster by accessing a cached copy than by making a database roundtrip. This setting creates a number of important issues such as maintaining consistency among copies of the same data item. Numerous techniques have been proposed to achieve caching and replication while maintaining consistency among the replicas. A closer investigation of these schemes reveals that no one scheme can be optimal for all environments. In this study we look at invalidation protocols for achieving consistency in systems that use distributed caching. We propose heuristics for dynamic adaptation of these protocols for cache consistency. These heuristics aim at propagating invalidations while reducing the cost of data transfer.