Miracle-dz/UniFAR-FTUs huggingface dataset:
Availability Verification of Effluent from BFT Inland Aquaculture for Urban Agricultural Fertilizer through Cherry Tomato Cultivation

As the interest in urban agriculture and people’s demand for eco-friendly food grow, the number of urban gardeners who directly grow and harvest will increase. The aim of this study was to compare the effect of conventional fertilizer with the effluent water from the biofloc technology inland aquaculture in the concept of resource circulation as a substitute for fertilizer used in urban agriculture. In order to verify the effect of fertilizer on the cultivation of cherry tomato, tomato seedlings were transplanted on the horticultural soil without nutrients and treated for 8 weeks. Experimental treatment was carried out in five treatments: control, hyponex solution (HS), slow-released fertilizer (SF), effluent water daily treatment (DE), and effluent water treatment once a week (WE). The growth characteristics of the cherry tomatoes showed significant differences among the treatments except for root length. In the case of plant length was shown HS=WE›DE=SF›control, and stem diameter was shown DE=SF ›WE=HS›control. It was found that HS and WE were not significantly different in shoot length and diameter, and DE and SF showed no difference. In the case of number of leaves, HS, DE, and WE showed a significantly higher level than SF and control. In other growth characteristics, DE and SF showed higher growth. As for the growth of cherry tomato fruit, the sugar content did not show any significant difference among the treatments except control. Weight per fruit and yield were significantly higher in HS and WE than DE and SF. Based on these results, it is considered that the use of effluent water is comparable to the use of urban agricultural fertilizer as compared with chemical fertilizers in cultivating crops.
Synonymous Somatic Variants in Human Cancer Are Not Infamous: A Plea for Full Disclosure in Databases and Publications

Single‐nucleotide variants (SNVs) are the most frequent genetic changes found in human cancer. Most driver alterations are missense and nonsense variants localized in the coding region of cancer genes. Unbiased cancer genome sequencing shows that synonymous SNVs (sSNVs) can be found clustered in the coding regions of several cancer oncogenes or tumor suppressor genes suggesting purifying selection. sSNVs are currently underestimated, as they are usually discarded during analysis. Furthermore, several public databases do not display sSNVs, which can lead to analytical bias and the false assumption that this mutational event is uncommon. Recent progress in our understanding of the deleterious consequences of these sSNVs for RNA stability and protein translation shows that they can act as strong drivers of cancer, as demonstrated for several cancer genes such as TP53 or BCL2L12. It is therefore essential that sSNVs be properly reported and analyzed in order to provide an accurate picture of the genetic landscape of the cancer genome.
Physical and mental health costs of traumatic war experiences among Civil War veterans.

BACKGROUND Hundreds of thousands of soldiers face exposure to combat during wars across the globe. The health effects of traumatic war experiences have not been adequately assessed across the lifetime of these veterans. OBJECTIVE To identify the role of traumatic war experiences in predicting postwar nervous and physical disease and mortality using archival data from military and medical records of veterans from the Civil War. DESIGN An archival examination of military and medical records of Civil War veterans was conducted. Degree of trauma experienced (prisoner-of-war experience, percentage of company killed, being wounded, and early age at enlistment), signs of lifetime physician-diagnosed disease, and age at death were recorded. SETTING AND PARTICIPANTS The US Pension Board surgeons conducted standardized medical examinations of Civil War veterans over their postwar lifetimes. Military records of 17,700 Civil War veterans were matched to postwar medical records. MAIN OUTCOME MEASURES Signs of physician-diagnosed disease, including cardiac, gastrointestinal, and nervous disease; number of unique ailments within each disease; and mortality. RESULTS Military trauma was related to signs of disease and mortality. A greater percentage of company killed was associated with signs of postwar cardiac and gastrointestinal disease (incidence risk ratio [IRR], 1.34; P < .02), comorbid nervous and physical disease (IRR, 1.51; P < .005), and more unique ailments within each disease (IRR, 1.14; P < .005). Younger soldiers (<18 years), compared with older enlistees (>30 years), showed a higher mortality risk (hazard ratio, 1.52), signs of comorbid nervous and physical disease (IRR, 1.93), and more unique ailments within each disease (IRR, 1.32) (P < .005 for all), controlling for time lived and other covariates. CONCLUSIONS Greater exposure to death of military comrades and younger exposure to war trauma were associated with increased signs of physician-diagnosed cardiac, gastrointestinal, and nervous disease and more unique disease ailments across the life of Civil War veterans. Physiological mechanisms by which trauma might result in disease are discussed.
Production and preservation of the smallest drumlins

Abstract Few very small drumlins are typically mapped in previously glaciated landscapes, which might be an important signature of subglacial processes or an observational artefact. One hundred and forty-three newly emergent drumlins, recently sculpted by the Múlajökull glacier, have been mapped using high-resolution LiDAR and aerial photographs in addition to field surveying. In this paper, these are used as evidence that few small drumlins (e.g., height H 4 m, width W 40 m, length L 100 m) are produced; at least, few survive to pass outside the ice margin in this actively forming drumlin field. Specifically, the lack of a multitude of small features seen in other landforms (e.g., volcanoes) is argued not to be due to (i) Digital Elevation Model resolution or quality, (ii) mapper ability in complex (i.e., anthropogenically cluttered or vegetated) landscapes or (iii) post-glacial degradation at this site. So, whilst detection ability must still be at least acknowledged in drumlin mapping, and ideally corrected for in quantitative analyses, this observation can now be firmly taken as a constraint upon drumlin formation models (i.e., statistical, conceptual or numerical ice flow). Our preferred explanation for the scarcity of small drumlins, at least at sites similar to Múlajökull (i.e., ice lobes with near-margin drumlin genesis), is that they form stochastically during multiple surge cycles, evolving from wide and gentle pre-existing undulations by increasing rapidly in amplitude before significant streamlining occurs.
Progesterone receptor modulators in gynaecological practice

The sex steroid progesterone plays a major role in the regulation of female reproductive activity. Many synthetic progestogens have been developed and introduced into clinical practice and as contraceptive agents they have revolutionized fertility control and the management of benign gynecological conditions such as endometriosis. This article discusses the development of progesterone receptor modulators (PRMSs) and focuses on the evidence for the use of the PRMs that have been administered in clinical trials to date. Mifepristone is licensed for use in termination of pregnancy buts its potential advantages for use in contraception management of heavy menstrual bleeding uterine fibroids and endometriosis as well as in non-gynecological and oncological conditions have also been highlights. The further development of related compounds including Asoprisnil and Ulipristal has been obstructed by the controversial political issues concerning their abortifacient properties. In the future it is hoped that long-term studies will confirm the safety and efficacy of these compounds.
Why We Don't Need Self-Esteem: On Fundamental Needs, Contingent Love, and Mindfulness

Self-esteem would appear to be a laudable quality. Indeed, from a superficial view, what could be wrong with esteeming the self? Esteeming oneself would seem akin to the other prescriptions of modern social-cognitive psychology: Be optimistic; hold positive illusions; expect success; feel efficacious; be happy. But like many of these “positive” prescriptions, the admonition to esteem oneself is more complex and problematic than it seems. We believe that Kernis (this issue), in working to disentangle the issues of level of self-esteem from its stability, has brought some of the problematic dynamics of “self-esteeming” into the forefront. Our comments, derived from both self-determination theory (SDT; Ryan & Deci, 2000) and Buddhist perspectives, suggest some reasons why. Extending the issues raised by Kernis, previous SDT formulations of contingent and noncontingent self-esteem (e.g., Deci & Ryan, 1995), and our recent findings concerning mindfulness (Brown & Ryan, 2003), we suggest that when self-esteeming processes are salient there is something awry with self-regulation, and with well-being. Based on SDT, we argue that, although self-evaluation is a “natural” human tendency with both evolutionary (Sedikedes & Skowronski, 2000) and developmental (Ryan & Kuzckowski, 1994) foundations, ongoing concern with the worth of the self is a byproduct of need deprivation or conflict. Specifically, the salience of processes in which the self is esteemed or disparaged is etiologically linked with the experience of contingent regard by significant others. We hypothesize that contingent regard increases one’s proneness to introjection, a form of behavioral regulation in which one’s actions are motivated by desires to gain (or not lose) self or other approval. Introjection, in turn, leaves one vulnerable to exogenous social pressures, the pursuit of unfulfilling goals, and the inauthentic living that can follow from them. Based on Buddhist perspectives, we further suggest that regulation based on mindfulness, rather than on contingent self-regard, is associated with healthier and more vital living, and provides a basis for acting more authentically.
Is mindfulness research methodology improving over time? A systematic review

Background Despite an exponential growth in research on mindfulness-based interventions, the body of scientific evidence supporting these treatments has been criticized for being of poor methodological quality. Objectives The current systematic review examined the extent to which mindfulness research demonstrated increased rigor over the past 16 years regarding six methodological features that have been highlighted as areas for improvement. These feature included using active control conditions, larger sample sizes, longer follow-up assessment, treatment fidelity assessment, and reporting of instructor training and intent-to-treat (ITT) analyses. Data sources We searched PubMed, PsychInfo, Scopus, and Web of Science in addition to a publically available repository of mindfulness studies. Study eligibility criteria Randomized clinical trials of mindfulness-based interventions for samples with a clinical disorder or elevated symptoms of a clinical disorder listed on the American Psychological Association’s list of disorders with recognized evidence-based treatment. Study appraisal and synthesis methods Independent raters screened 9,067 titles and abstracts, with 303 full text reviews. Of these, 171 were included, representing 142 non-overlapping samples. Results Across the 142 studies published between 2000 and 2016, there was no evidence for increases in any study quality indicator, although changes were generally in the direction of improved quality. When restricting the sample to those conducted in Europe and North America (continents with the longest history of scientific research in this area), an increase in reporting of ITT analyses was found. When excluding an early, high-quality study, improvements were seen in sample size, treatment fidelity assessment, and reporting of ITT analyses. Conclusions and implications of key findings Taken together, the findings suggest modest adoption of the recommendations for methodological improvement voiced repeatedly in the literature. Possible explanations for this and implications for interpreting this body of research and conducting future studies are discussed.
FEATURE ARTICLE Distinctive Neurons of the Anterior Cingulate and Frontoinsular Cortex: A Historical Perspective

Human anterior cingulate and frontoinsular cortices participate in healthy social-emotional processing. These regions feature 2 related layer 5 neuronal morphotypes, the von Economo neurons and fork cells. In this paper, we review the historical accounts of these neurons and provide a German-to-English translation of von Economo’s seminal paper describing the neurons which have come to bear his name. We close with a brief discussion regarding the functional and clinical relevance of these neurons and their home regions.
Enhanced antibiotic multi-resistance in nasal and faecal bacteria after agricultural use of streptomycin

Streptomycin is used in arboriculture to control fire blight. Using sheep as a model, multidrug-resistant bacteria in mammals were found to be selected after the intentional release of streptomycin into the environment. Escherichia coli and Staphylococcus spp. were isolated from the faeces and nasal cavities, respectively, of sheep grazing on a field sprayed with streptomycin at concentrations used in orchards (test group) and on a field without streptomycin (control group). Before the application of streptomycin, the percentage of streptomycin-resistant E. coli isolates in faeces was 15.8% in the control group and 14.7% in the test group. After the application of streptomycin, the overall number of streptomycin-resistant E. coli isolates was significantly higher in the test group (39.9%) than in the control group (22.3%). Streptomycin-resistant Staphylococcus isolates were only detected after the application of streptomycin. Streptomycin resistance was frequently associated with resistance to sulfamethoxazole, ampicillin, tetracycline and chloramphenicol and less frequently to cefotaxime in E. coli, and to tetracycline, fusidic acid and tiamulin in Staphylococcus spp. This study shows that the application of low concentrations of streptomycin on grass, as occurs during the spraying of orchards, selects for multidrug-resistant nasal and enteric bacterial flora, including extended-spectrum beta-lactamase-producing E. coli.
Study protocol: a phase III randomised, double-blind, parallel arm, stratified, block randomised, placebo-controlled trial investigating the clinical effect and cost-effectiveness of sertraline for the palliative relief of breathlessness in people with chronic breathlessness

Introduction Breathlessness remains a highly prevalent and distressing symptom for many patients with progressive life-limiting illnesses. Evidence-based interventions for chronic breathlessness are limited, and there is an ongoing need for high-quality research into developing management strategies for optimal palliation of this complex symptom. Previous studies have suggested that selective serotonin reuptake inhibitors such as sertraline may have a role in reducing breathlessness. This paper presents the protocol for a large, adequately powered randomised study evaluating the use of sertraline for chronic breathlessness in people with progressive life-limiting illnesses. Methods and analysis A total of 240 participants with modified Medical Research Council Dyspnoea Scale breathlessness of level 2 or higher will be randomised to receive either sertraline or placebo for 28 days in this multisite, double-blind study. The dose will be titrated up every 3 days to a maximum of 100 mg daily. The primary outcome will be to compare the efficacy of sertraline with placebo in relieving the intensity of worst breathlessness as assessed by a 0–100 mm Visual Analogue Scale. A number of other outcome measures and descriptors of breathlessness as well as caregiver assessments will also be recorded to ensure adequate analysis of participant breathlessness and to allow an economic analysis to be performed. Participants will also be given the option of continuing blinded treatment until either study data collection is complete or net benefit ceases. Appropriate statistical analysis of primary and secondary outcomes will be used to describe the wealth of data obtained. Ethics and dissemination Ethics approval was obtained at all participating sites. Results of the study will be submitted for publication in peer-reviewed journals and the key findings presented at national and international conferences. Trial registration number ACTRN12610000464066.
Regulation of protein synthesis in vesicular stomatitis virus-infected mouse L-929 cells by decreased protein synthesis initiation factor 2 activity

Infection of mouse L-cell spinner cultures by vesicular stomatitis virus (VSV) effected the selective translation of viral mRNA by 4h after viral adsorption. Cell-free systems prepared from mock- and VSV-infected cells reflected this phenomenon; protein synthesis was reduced in the virus-infected cell lysate by approximately 75% compared with the mock-infected (control) lysate. This effect appeared to be specific to protein synthesis initiation since (i) methionine incorporation into protein from an exogenous preparation of initiator methionyl-tRNA gave completely analogous results and (ii) the addition of a ribosomal salt wash (containing protein synthesis initiation factors) stimulated protein synthesis by the infected cell lysate but had no effect on protein synthesis by the control. Micrococcal nuclease-treated (initiation-dependent) VSV-infected cell lysates were not able to translate L-cell mRNA unless they were supplemented with a ribosomal salt wash; a salt wash from ribosomes from uninfected cells effected a quicker recovery than a salt wash from ribosomes from infected cells. When salt wash preparations from ribosomes from uninfected and infected cells were tested for initiation factor 2 (eIF-2)-dependent ternary complex capacity with added GTP and initiator methionyl-tRNA, we found that the two preparations contained equivalent levels of eIF-2. However, initiation complex formation by the factor from virus-infected cells proceeded at a reduced initial rate compared with the control. When the lysates were supplemented with a partially purified eIF-2 preparation, recovery of activity by the infected cell lysate was observed. Mechanisms by which downward regulation of eIF-2 activity might direct the selective translation of viral mRNA in VSV-infected cells are proposed.
Use of a Multiantigen Detection Algorithm for Diagnosis of Kaposi's Sarcoma-Associated Herpesvirus Infection

ABSTRACT The ability to readily and accurately diagnose Kaposi's sarcoma-associated herpesvirus (KSHV, or human herpesvirus 8) infection in individuals remains a demanding task. Among the available diagnostic methods, sensitivities and specificities range widely, and many are inadequate for large-scale screening studies. We examined a serological algorithm for detecting KSHV in human sera having high sensitivity and specificity. This method uses previously described open reading frame (ORF) K8.1 and ORF65 peptide-based enzyme-linked immunosorbent assays and a novel purified recombinant full-length LANA1 protein. We generated two multiantigen algorithms: one that maximized sensitivity and one that maximized specificity. These serological algorithms were then used to evaluate seroprevalence rates among populations of clinical and epidemiological importance. The serological algorithms yielded sensitivities of 96% and 93% and specificities of 94% and 98% for the more sensitive and specific algorithms, respectively. Among kidney donors, seroprevalence was low, 4.0% (2/50), and similar to that of blood donors (P = 0.46; odds ratio [OR], 1.4; confidence interval [CI], 0.14 to 7.9) using the highly specific algorithm. Using the sensitive algorithm, 8.0% (4/50) were infected compared to 6.4% (16/250) observed among blood donors (OR, 1.3; CI, 0.41 to 4.0; P = 0.43). Among subjects requiring bone marrow transplantation, seroprevalence rates were not elevated compared to those of blood donors (OR, 2.0; 95% CI, 0.10 to 122.9; P = 0.50). Because the need for high-quality KSHV detection methods are warranted and because questions remain about the optimal methods for assessing KSHV infection in individuals, we propose a systematic approach to standardize and optimize the assessment of KSHV infection rates using a combination of established and novel serological assays and methods.
Temporal Disaggregation Using Multivariate Structural Time Series Models

In this paper, we provide a multivariate framework for temporal disaggregation of time series observed at a given frequency into higher frequency time series. The suggested method uses the seemingly unrelated time series equations model and it is estimated by the Kalman filter. The methodology is flexible enough to allow for almost any kind of temporal disaggregation problems of both raw and seasonally adjusted time series. Comparisons with other temporal disaggregation methods proposed in the literature are presented using a wide OECD data set. Copyright 2005 Royal Economic Society
Coordination and navigation of heterogeneous MAV–UGV formations localized by a ‘hawk-eye’-like approach under a model predictive control scheme

An approach for coordination and control of 3D heterogeneous formations of unmanned aerial and ground vehicles under hawk-eye-like relative localization is presented in this paper. The core of the method lies in the use of visual top-view feedback from flying robots for the stabilization of the entire group in a leader–follower formation. We formulate a novel model predictive control-based methodology for guiding the formation. The method is employed to solve the trajectory planning and control of a virtual leader into a desired target region. In addition, the method is used for keeping the following vehicles in the desired shape of the group. The approach is designed to ensure direct visibility between aerial and ground vehicles, which is crucial for the formation stabilization using the hawk-eye-like approach. The presented system is verified in numerous experiments inspired by search-and-rescue applications, where the formation acts as a searching phalanx. In addition, stability and convergence analyses are provided to explicitly determine the limitations of the method in real-world applications.
Are elemental and strontium isotopic microchemistry of otolith and histomorphometrical characteristics of vertebral bone useful to resolve the eel Anguilla obscura status in Lalolalo lake in Wallis Island

Otolith Sr/Ca, Ba/Ca and 87 Sr/ 86 Sr ratios and vertebral bone histomorphometry were used to investigate the life-history of Anguilla obscura eels from an enclosed lake, Lalolalo (Wallis Island in the Pacific), with no apparent connection with the sea. 87 Sr/ 86 Sr isotopic ratio from the core region gives evidence of indisputable marine origin of eels caught in the lake suggesting that underground connections between the lake and the sea exist. Sr/Ca and Ba/Ca ratios recorded after the elver mark are undifferentiated from seawater ones, thus limiting their used as marker of entrance in the lake and movement. However, 87 Sr/ 86 Sr isotopic ratio demonstrated that: 1) eels enter in the lake just after their metamorphosis and spend their entire adult life in the lake and 2) the lake chemistry is consistent with 1 % seawater-like contribution and 99 % basalt weathering and/or geothermal spring contribution. The vertebrae do not show a particular demineralization of bone matrix (45-52 %). Reversely, the study of bone compactness shows an important loss of bone that favors the hypothesis of a genital maturation that arises in the ecological state of the lake.