Miracle-dz/UniFAR-FTUs huggingface dataset:
Risks vs benefits of glatiramer acetate: a changing perspective as new therapies emerge for multiple sclerosis

An understanding of the risks, benefits, and relative value of glatiramer acetate (GA) in multiple sclerosis (MS) has been evolving based on recently completed head-to-head studies: REGARD (REbif vs Glatiramer Acetate in Relapsing MS Disease); BEYOND (Betaseron Efficacy Yielding Outcomes of a New Dose); and BECOME (BEtaseron vs COpaxone in Multiple Sclerosis with Triple-Dose Gadolinium and 3-Tesla MRI Endpoints). Outcomes in the primary endpoints of these trials showed no significant differences between GA and high-dose beta-interferons (IFNβs). Results of the PreCISe (Early GA Treatment in Delaying Conversion to Clinically Definite Multiple Sclerosis [CDMS] in Subjects Presenting With a Clinically Isolated Syndrome [CIS]) trial led to the US Food and Drug Administration approval of GA in patients with a CIS. Furthermore, the ongoing follow-up study to the original pivotal GA trial, now extending beyond 15 years, continues to support the safety of GA. Currently, GA and IFNβs are no longer the only immunomodulators available for MS. Introduction of the monoclonal antibody, natalizumab (Tysabri®; Biogen Idec, Inc., Cambridge, MA, USA) provides an alternative immunomodulator for MS and has changed the therapeutic landscape dramatically. However, the rare but serious cases of progressive multifocal leukoencephalopathy that have occurred with natalizumab have raised concerns among clinicians and patients about using this agent and some of the emerging agents. The potential risks and benefits of the emerging therapies (cladribine, alemtuzumab, rituximab, fingolimod, laquinimod, teriflunomide, and dimethyl fumarate) based on phase II/III trials, as well as their use for indications other than MS, will be presented. This review provides available data on GA, natalizumab, and the emerging agents to support new developments in our understanding of GA and how its long-standing role as a first-line therapy in MS will evolve within the increasingly complex MS therapeutic landscape.
The Realized RSDC model

We introduce a new model for the joint dependence between returns and realized measures of volatility for multiple assets. This model borrows the methodology of the Realized GARCH of Hansen, Huang, and Shek (2012) to model the conditional variance of the returns. To model the dependence between the assets’ returns, we introduce a regime switching model where (i) the correlations are constant within the regimes but different across regimes and (ii) both the returns and realized measures are subject to this regime switching process. Contrary to the RSDC model of Pelletier (2006), we can estimate the correlation process of the returns using the realized measures on top of the returns. An empirical application using transaction level data illustrates the performance of the model. ∗Mailing address: Department of Economics, Campus Box 8110, North Carolina State University, Raleigh, 276958110, USA. e-mail: denis pelletier@ncsu.edu. Web site: http://www4.ncsu.edu/∼dpellet. †Mailing address: Department of Economics, Campus Box 8110, North Carolina State University, Raleigh, 276958110, USA. e-mail: ankassi@ncsu.edu.
Urban Lawyers: The New Social Structure of the Bar

Over the past several decades, the number of lawyers in large cities has doubled, women have entered the bar at an unprecedented rate, and the scale of firms has greatly expanded. This immense growth has transformed the nature and social structure of the legal profession. In the most comprehensive analysis of the urban bar to date, Urban Lawyers presents a compelling portrait of how these changes continue to shape the field of law today. Drawing on extensive interviews with Chicago lawyers, the authors demonstrate how developments in the profession have affected virtually every aspect of the work and careers of urban lawyers - their relationships with clients, job tenure and satisfaction, income, social and political values, networks of professional connections, and patterns of participation in the broader community. Yet despite the dramatic changes, much remains the same. Stratification of income and power based on gender, race, and religious background, for instance, still maintains inequality within the bar. The authors of Urban Lawyers conclude that organizational priorities will likely determine the future direction of the legal profession. And with this landmark study as their guide, readers will be able to make their own informed predictions.
Explaining the Impact of Social Policy on Child Mortality: A Cross-country Statistical Analysis and a Case Study of Vietnam

This thesis examines the impact of social policies on child mortality. It argues that structural factors explain most of the variation in child mortality across countries and time. But that in Vietnam the state implemented effective social policies; leading to this country having low child mortality for its structural factors (income, income equality and women’s power). This thesis uses panel data econometrics to investigate the structural determinants of child mortality. Our model shows that national income and women’s power reduce, and income inequality increases, child mortality. These independent variables are significant at the 1% level and explain over 90% of the variation in child mortality when our dependent variable is under-five mortality from the World Development Indicators dataset. These results are robust to changes in the functional form, lag structure, dataset and measure of child mortality used in our model. Vietnam is an outlier in our model; it has low child mortality for its structural factors. We consider that Vietnam’s effective social policies may explain why it is an outlier. This thesis also undertakes a detailed case study of Vietnam’s social policies. We argue and provide considerable evidence that in Vietnam the government implemented effective family planning, child immunization and female education policies and that these reduced child mortality. Developing countries are currently committed through MDG4 to reducing under-five mortality by two thirds between 1990 and 2015. Our results show that developing countries are unlikely to achieve this goal because social policies have a small impact on child mortality relative to structural factors.
Programmable thermal dissociation of reactive gaseous mercury – a potential approach to chemical speciation: results from a field study

Abstract. The use of programmable thermal dissociation (PTD) as an approach to investigating the chemical speciation of reactive gaseous mercury (RGM, Hg 2+ ) has been explored in a field study. In this approach RGM is collected on a denuder and analyzed using PTD. The denuder is placed in an oven and the dissociation of the RGM is measured, as a function of temperature, by monitoring the evolution of elemental mercury (GEM, Hg 0 ) in real time using laser-induced fluorescence (LIF). The technique was tested in a field campaign at a coal-fired power plant in Pensacola, Florida. Uncoated tubular denuders were used to obtain samples from the plant's stack exhaust gases and from the stack plume, downwind of the stack using an airship. The PTD profiles from these samples were compared with PTD profiles of HgCl 2 .
On the asymptotic behavior of flood peak distributions – theoretical results

This paper presents some analytical results and numerical illustrations on the asymptotic properties of flood peak distributions obtained through derived flood frequency approaches. It confirms and extends the results of previous works: i.e. the shape of the flood peak distributions are asymptotically controlled by the rainfall statistical properties, given limited and reasonable assumptions concerning the rainfall-runoff process. This previous result is partial so far: only two types of rainfall intensity distributions have been considered (extreme value distributions of types I and II), and the impact of the rainfall spatial heterogeneity has not been studied. From a practical point of view, it provides a general framework for analysis of the outcomes of previous works based on derived flood frequency approaches and leads to some proposals for the estimation of very large return-period flood quantiles. This paper, focussed on asymptotic distribution properties, does not propose any new approach for the extrapolation of flood frequency distribution to estimate intermediate return period flood quantiles. Nevertheless, the large distance between frequent flood peak values and the asymptotic values as well as the simulations conducted in this paper help quantifying the ill condition of the problem of flood frequency distribution extrapolation: it illustrates how large the range of possibilities for the shapes of flood peak distributions is.
Surgeons' Exposure to Radiation in Single- and Multi-Level Minimally Invasive Transforaminal Lumbar Interbody Fusion; A Prospective Study

Although minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) has widely been developed in patients with lumbar diseases, surgeons risk exposure to fluoroscopic radiation. However, to date, there is no studies quantifying the effective dose during MIS-TLIF procedure, and the radiation dose distribution is still unclear. In this study, the surgeons' radiation doses at 5 places on the bodies were measured and the effective doses were assessed during 31 consecutive 1- to 3-level MIS-TLIF surgeries. The operating surgeon, assisting surgeon, and radiological technologist wore thermoluminescent dosimeter on the unshielded thyroid, chest, genitals, right middle finger, and on the chest beneath a lead apron. The doses at the lens and the effective doses were also calculated. Mean fluoroscopy times were 38.7, 53.1, and 58.5 seconds for 1, 2, or 3 fusion levels, respectively. The operating surgeon's mean exposures at the lens, thyroid, chest, genitals, finger, and the chest beneath the shield, respectively, were 0.07, 0.07, 0.09, 0.14, 0.32, and 0.05 mSv in 1-level MIS-TLIF; 0.07, 0.08, 0.09, 0.18, 0.34, and 0.05 mSv in 2-level; 0.08, 0.09, 0.14, 0.15, 0.36, and 0.06 mSv in 3-level; and 0.07, 0.08, 0.10, 0.15, 0.33, and 0.05 mSv in all cases. Mean dose at the operating surgeon's right finger was significantly higher than other measurements parts (P<0.001). The operating surgeon's effective doses (0.06, 0.06, and 0.07 mSv for 1, 2, and 3 fusion levels) were low, and didn't differ significantly from those of the assisting surgeon or radiological technologist. Revision MIS-TLIF was not associated with higher surgeons' radiation doses compared to primary MIS-TLIF. There were significantly higher surgeons' radiation doses in over-weight than in normal-weight patients. The surgeons' radiation exposure during MIS-TLIF was within the safe level by the International Commission on Radiological Protection's guidelines. The accumulated radiation exposure, especially to surgeon's hands, should be carefully monitored.
Continuum electrostatics for ionic solutions with non-uniform ionic sizes

This work concerns electrostatic properties of an ionic solution with multiple ionic species of possibly different ionic sizes. Such properties are described by the minimization of an electrostatic free-energy functional of ionic concentrations. Bounds are obtained for ionic concentrations with low electrostatic free energies. Such bounds are used to show that there exists a unique set of equilibrium ionic concentrations that minimizes the free-energy functional. The equilibrium ionic concentrations are found to depend sorely on the equilibrium electrostatic potential, resembling the classical Boltzmann distributions that relate the equilibrium ionic concentrations to the equilibrium electrostatic potential. Unless all the ionic and solvent molecular sizes are assumed to be the same, explicit formulae of such dependence are, however, not available in general. It is nevertheless proved that in equilibrium the ionic charge density is a decreasing function of the electrostatic potential. This determines a variational principle with a convex functional for the electrostatic potential. Mathematics Subject Classification: 35J20, 35J60, 49S05, 81V55, 92E99
Intelligent Vehicle Recognition based on Wireless Sensor Network

One of the main requirements of any intelligent transportation system is to be able to identify vehicles in the traffic. This paper presents an intelligent vehicle identification system used within a complete solution for a traffic monitoring system thatusesa novelwireless sensor network architecture to monitor traffic. A novel wireless sensor network architecture to monitor traffic is proposed where a visual sensor node captures images of the traffic and sends them to the traffic control center for processing. Also, this paper compares between three main localization and recognition algorithms. To locate the vehicle logo in the traffic image a symmetry detection algorithm is used to detect the inherent symmetry in vehicle frontal images. A fine location of the logo is identified using three different methods in the region marked by the symmetry line. After locating the logo three feature sets are extracted and presented to the classifier to correctly identify the type of the vehicle. The results of the localization and recognition algorithms show the efficiency of the presented system in identifying vehicle types with a recognition rate over 90%.
Occupational Aspirations and Experiences of College Women.

This paper discusses women who enter male-dominated professions, so-called "Role Innovators", and some of the personality and background characteristics of these women. Findings include that Role-Innovators* more to be working and to Role-Innovative professions themselves; although the daughters 1 aspirations and commitments were greater than their mothers 1 Role-Innovators, the Avoid Success significantly and negatively related to the importance given to having opportunities for leadership in choosing one's occupation, suggesting that embarrassment over prominence, particularly among male colleagues, the
Metabolic Gene Polymorphism Frequencies in Control Populations 1

Using the International Project on Genetic Susceptibility to Environmental Carcinogens (GSEC) database containing information on over 15,000 control (noncancer) subjects, the allele and genotype frequencies for many of the more commonly studied metabolic genes (CYP1A1, CYP2E1, CYP2D6, GSTM1, GSTT1, NAT2, GSTP, and EPHX) in the human population were determined. Major and significant differences in these frequencies were observed between Caucasians ( n 12,525), Asians (n 2,136), and Africans and African Americans (n 996), and some, but much less, heterogeneity was observed within Caucasian populations from different countries. No differences in allele frequencies were seen by age, sex, or type of controls (hospital patients versus population controls). No examples of linkage disequilibrium between the different loci were detected based on comparison of observed and expected frequencies for combinations of specific alleles.
Propagating Oscillatory Shock Model for QPOS in GRO J1655-40 During the March 2005 Outburst

GRO 1655-40, a well known black hole candidate, showed renewed X-ray activity in March 2005 after being dormant for almost eight years. It showed very prominent quasi-periodic oscillations. We analysed the data of two observations in this {\it Rapid Communication}, one taken on March 2nd, 2005 and the other taken on the March 11th, 2005. On March 2nd, 2005 the shock was weak and the QPO was seen in roughly all energies. On March 11th, 2005 the power density spectra showed that quasi-periodic oscillations (QPOs) were exhibited in harder X-rays. On the first day, the QPO was seen at 0.13Hz and on the second day, the QPO was seen at $\sim 6.5$Hz with a spectral break at $\sim 0.1$Hz. We analysed the QPOs for the period 25th Feb. 2005 to 12th of March, 2005 and showed that the frequency of QPO increased monotonically from 0.088Hz to 15.01Hz. This agrees well if the oscillating shock is assumed to propagate with a constant velocity. On several days we also noticed the presence of very high frequency QPOs and for the first time we detected QPOs in the 600-700Hz range, the highest frequency range so far reported for any black hole candidate.
Analyzing the evolutionary history of the logical design of object-oriented software

Today, most object-oriented software systems are developed using an evolutionary process model. Therefore, understanding the phases that the system's logical design has gone through and the style of their evolution can provide valuable insights in support of consistently maintaining and evolving the system, without compromising the integrity and stability of its architecture. In this paper, we present a method for analyzing the evolution of object-oriented software systems from the point of view of their logical design. This method relies on UMLDiff, a UML-structure differencing algorithm, which, given a sequence of UML class models corresponding to the logical design of a sequence of system code releases, produces a sequence of "change records" that describe the design-level changes between subsequent system releases. This change-records sequence is subsequently analyzed from the perspective of each individual system class, to produce the class-evolution profile, i.e., a class-specific change-records' sequence. Three types of longitudinal analyses - phasic, gamma, and optimal matching analysis - are applied to the class-evolution profiles to recover a high-level abstraction of distinct evolutionary phases and their corresponding styles and to identify class clusters with similar evolution trajectories. The recovered knowledge facilitates the overall understanding of system evolution and the planning of future maintenance activities. We report on one real-world case study evaluating our approach.
Responses to crizotinib in patients with ALK-positive lung adenocarcinoma who tested immunohistochemistry (IHC)-positive and fluorescence in situ hybridization (FISH)-negative

Although the Ventana immunohistochemistry (IHC) platform for detecting anaplastic lymphoma kinase gene (ALK) (D5F3) expression was recently approved by the US Food and Drugs Administration (FDA), fluorescence in situ hybridization (FISH) is still the “gold-standard” method recommended by the US National Comprehensive Cancer Network (NCCN) guideline for NSCLC. We evaluated 6 ALK-positive lung adenocarcinoma patients who tested Ventana IHC-positive and FISH-negative and assessed their clinical responses to the ALK tyrosine kinase inhibitor (TKI) crizotinib. Histologic and cytologic specimens from the 6 patients were stained with Ventana anti-ALK(D5F3) rabbit monoclonal primary antibody using the OptiView™ DAB IHC detection kit and OptiView™ amplification kit on a Ventana BenchMark XT processor. In addition, they were also tested by FISH, qRT-PCR, next-generation sequencing (NGS), and RNAscope ISH analysis. All patients received crizotinib treatment and their follow-up clinical data were recorded. The objective response rate achieved with crizotinib therapy was 66.7% (4/6 partial responses and 2/6 stable disease). One patient in whom a new fusion type (EML4->EXOC6B->ALK fusion) was identified obtained a partial response. These findings indicate that patients with ALK-positive lung adenocarcinoma who test Ventana IHC-positive and FISH-negative may still respond to crizotinib therapy.
Kinematic and electromyographic analysis of steady pectoral fin swimming in the surfperches

The musculoskeletal mechanism of pectoral fin propulsion was investigated in representatives of the two subfamilies of the Embiotocidae (surfperches). Kinematic and electromyographic records of steady swimming by the open-water cruiser Amphistichus rhodoterus and the benthic maneuverer Embiotoca lateralis were compared at 80 % of the species' respective pectoral­caudal gait transition speeds. Synchronized records of fin movement and the intensity of pectoral muscle activity allowed previous hypotheses of muscle function, based on anatomical lines of action, to be tested. Divisions of the pectoral musculature inserting on the central and trailing- edge fin rays serve simple functions of abduction and adduction. Muscles controlling the fin's leading edge, by contrast, play more complex roles during the fin stroke, including deceleration of the fin at the downstroke­upstroke transition and rotation of the adducted fin during the non-propulsive period between fin beats. In spite of their phylogenetic and ecological divergence, the surfperches exhibit a number of mechanistic similarities which probably characterize the family. The timings of kinematic events and the maximal excursions of the fin tip, as well as the temporal order of muscle activation and the time to peak activity, are largely conserved. The predominant dorsoventral component of fin movement during the stride is consistent with a lift-based mechanism of propulsion. E. lateralis exhibits a greater anteroposterior range of motion and a more continuous period of fine motor control of the fin than A. rhodoterus, differences which may correspond to the species' respective capacities for maneuvering. Mechanistic variation in the family is associated with rather minor structural differences (in fin shape and fin base orientation). Owing to the similar functional demands placed on the pectoral fins of many fishes, it is probable that the mechanistic details of embiotociform swimming are widely distributed within the Perciformes.
Student Progress in Higher Education: What We Have Learned from Large-Scale Studies

This review examines student progress in higher education based on 28 articles examining 25 large-scale samples of first-year entrants in higher education programs in nine countries. These articles were obtained from a search of published and publicly available research on student departure. Although the results of the studies reviewed are heterogeneous, generalized trends emerge from the synthesis of this body of research on dropout behavior, completion, and time-to-degree. The vast majority of the empirical works reviewed indicate that personal characteristics, family background, prior attainment, and financial aid are important factors influencing students' progress. Although almost every empirical work estimates the impact of these variables, little attention has been directed toward understanding how university characteristics affect student departure; more research and more data clearly are needed to analyze these issues.
Characterization of Thermotolerant Chitinases Encoded by a Brevibacillus laterosporus Strain Isolated from a Suburban Wetland

To isolate and characterize chitinases that can be applied with practical advantages, 57 isolates of chitin-degrading bacteria were isolated from the soil of a suburban wetland. 16S rRNA gene analysis revealed that the majority of these strains belonged to two genera, Paenibacillus and Brevibacillus. Taking thermostability into account, the chitinases (ChiA and ChiC) of a B. laterosporus strain were studied further. Ni-NTA affinity-purified ChiA and ChiC were optimally active at pH 7.0 and 6.0, respectively, and showed high temperature stability up to 55 °C. Kinetic analysis revealed that ChiC has a lower affinity and stronger catalytic activity toward colloidal chitin than ChiA. With their stability in a broad temperature range, ChiA and ChiC can be utilized for the industrial bioconversion of chitin wastes into biologically active products.