Miracle-dz/UniFAR-FTUs huggingface dataset:
Enteric Neuropathy Can Be Induced by High Fat Diet In Vivo and Palmitic Acid Exposure In Vitro

Objective Obese and/or diabetic patients have elevated levels of free fatty acids and increased susceptibility to gastrointestinal symptoms. Since the enteric nervous system is pivotal in regulating gastrointestinal functions alterations or neuropathy in the enteric neurons are suspected to occur in these conditions. Lipid induced intestinal changes, in particular on enteric neurons, were investigated in vitro and in vivo using primary cell culture and a high fat diet (HFD) mouse model. Design Mice were fed normal or HFD for 6 months. Intestines were analyzed for neuronal numbers, remodeling and lipid accumulation. Co-cultures of myenteric neurons, glia and muscle cells from rat small intestine, were treated with palmitic acid (PA) (0 – 10−3 M) and / or oleic acid (OA) (0 – 10−3 M), with or without modulators of intracellular lipid metabolism. Analyses were by immunocyto- and histochemistry. Results HFD caused substantial loss of myenteric neurons, leaving submucous neurons unaffected, and intramuscular lipid accumulation in ileum and colon. PA exposure in vitro resulted in neuronal shrinkage, chromatin condensation and a significant and concentration-dependent decrease in neuronal survival; OA exposure was neuroprotective. Carnitine palmitoyltransferase 1 inhibition, L-carnitine- or alpha lipoic acid supplementation all counteracted PA-induced neuronal loss. PA or OA alone both caused a significant and concentration-dependent loss of muscle cells in vitro. Simultaneous exposure of PA and OA promoted survival of muscle cells and increased intramuscular lipid droplet accumulation. PA exposure transformed glia from a stellate to a rounded phenotype but had no effect on their survival. Conclusions HFD and PA exposure are detrimental to myenteric neurons. Present results indicate excessive palmitoylcarnitine formation and exhausted L-carnitine stores leading to energy depletion, attenuated acetylcholine synthesis and oxidative stress to be main mechanisms behind PA-induced neuronal loss.High PA exposure is suggested to be a factor in causing diabetic neuropathy and gastrointestinal dysregulation.
Dsc+Mock: a test case + mock class generator in support of coding against interfaces

Coding against interfaces is a powerful technique in object-oriented programming. It decouples code and enables independent development. However, code decoupled via interfaces poses additional challenges for testing and dynamic execution, as not all pieces of code that are necessary to execute a piece of code may be available. For example, a client class may be coded against several interfaces. For testing, however, no classes may be available that implement the interfaces. This means that, to support testing, we need to generate mock classes along with test cases. Current test case generators do not fully support this kind of independent development and testing. In this paper, we describe a novel technique for generating test cases and mock classes for object-oriented programs that are coded against interfaces. We report on our initial experience with an implementation of our technique for Java. Our prototype implementation achieved higher code coverage than related tools that do not generate mock classes, such as Pex.
ROSAT PSPC detection of soft X-ray absorption in GB 1428+4217: the most distant matter yet probed with X-ray spectroscopy

We report on a ROSAT PSPC observation of the highly luminous z=4.72 radio-loud quasar GB 1428+4217 obtained between 1998 December 11 and 17, the final days of the ROSAT satellite. The low-energy sensitivity of the PSPC detector was employed to constrain the intrinsic X-ray absorption of the currently most distant X-ray detected object. Here we present the detection of significant soft X-ray absorption towards GB 1428+4217, making the absorbing material the most distant matter yet probed with X-ray spectroscopy. X-ray variability by 25±8 per cent is detected on a time-scale of 6500 s in the rest frame. The X-ray variation requires an unusually high radiative efficiency η of at least 4.2, further supporting the blazar nature of the source.
Broadening girls' horizons: Effects of life skills education programme in rural Uttar Pradesh

This report is the result of a collaborative project undertaken by Prerana and the Population Council to implement a life skills education programme for unmarried adolescent girls in rural Uttar Pradesh and to evaluate its effectiveness. The intervention programme aimed to empower unmarried adolescent girls aged 13–17 years and address their vulnerabilities by building their agency; fostering egalitarian gender role attitudes; building awareness about sexual and reproductive health matters; developing vocational skills and future work aspirations; and influencing perceptions about marriage and their ability to negotiate marriage-related decisions, delaying marriage and first pregnancy. Prerana is a not-for-profit voluntary organisation that works to enhance the quality of life of individuals and communities through the formation of self-help groups, building awareness of sexual and reproductive health and developing capacity at the community level. Prerana provides direct service intervention and supports technical assistance in advocacy and research initiatives. The Population Council is an international, non-profit, non-governmental organisation that seeks to improve the well-being and reproductive health of current and future generations around the world and to help achieve a humane, equitable and sustainable balance between people and resources. The Council conducts biomedical, social science and public health research, and helps build research capacities in developing countries.
Knowledge Graph Completion via Complex Tensor Factorization

In statistical relational learning, knowledge graph completion deals with automatically understanding the structure of large knowledge graphs---labeled directed graphs---and predicting missing relationships---labeled edges. State-of-the-art embedding models propose different trade-offs between modeling expressiveness, and time and space complexity. We reconcile both expressiveness and complexity through the use of complex-valued embeddings and explore the link between such complex-valued embeddings and unitary diagonalization. We corroborate our approach theoretically and show that all real square matrices---thus all possible relation/adjacency matrices---are the real part of some unitarily diagonalizable matrix. This results opens the door to a lot of other applications of square matrices factorization. Our approach based on complex embeddings is arguably simple, as it only involves a Hermitian dot product, the complex counterpart of the standard dot product between real vectors, whereas other methods resort to more and more complicated composition functions to increase their expressiveness. The proposed complex embeddings are scalable to large data sets as it remains linear in both space and time, while consistently outperforming alternative approaches on standard link prediction benchmarks.
Association of genetic polymorphisms in CYP2E1, MPO, NQO1, GSTM1, and GSTT1 genes with benzene poisoning.

Metabolic enzymes involved in benzene activation or detoxification, including NAD(P)H, quinone oxidoreductase 1 (NQO1), cytochrome P450 2E1 (CYP2E1), myeloperoxidase (MPO), glutathione-S-transferase mu-1 (GSTM1), and glutathione-S-transferase theta-1 (GSTT1), were studied for their roles in human susceptibility to benzene poisoning. The potential interactions of these metabolic enzymes with lifestyle factors such as cigarette smoking and alcohol consumption were also explored. We studied 156 benzene-poisoning patients and 152 workers occupationally exposed to benzene in South China. Sequencing, denaturing HPLC, restriction fragment-length polymorphism, and polymerase chain reaction were used to detect polymorphisms on the promoters and complete coding regions of NQO1, CYP2E1, MPO, and the null genotypes of GSTM1 and GSTT1. Seventeen single nucleotide polymorphisms (SNPs) were identified in NQO1, CYP2E1, and MPO genes, including 6 novel SNPs in CYP2E1 and MPO. Of the subjects who smoked and drank alcohol, an 8.15-fold [95% confidence interval (CI), 1.43-46.50] and a 21.50-fold (95% CI, 2.79-165.79) increased risk of benzene poisoning, respectively, were observed among the subjects with two copies of NQO1 with a C-to-T substitution in cDNA at nucleotide 609 (c.609 C>T variation; i.e., NQO1 c.609 T/T) compared to those with the heterozygous or wild (NQO1 c.609 C/T and c.609 C/C) genotypes. Our data also indicated that individuals with CYP2E1 c. -1293 C/C and c. -1293 G/C, and NQO1 c.609 T/T, and GSTT1 null genotypes tended to be more susceptible to benzene toxicity. Our results suggest that the combined effect of polymorphisms in NQO1, CYP2E1, and GSTT1 genes and lifestyle factors might contribute to benzene poisoning.
Biofuels and the global food balance: bioenergy and agriculture promises and challenges

"Rising world fuel prices, the growing demand for energy, and concerns about global warming are the key factors driving the increasing interest in renewable energy sources, and in biofuels in particular. But some policymakers and analysts have voiced concern that aggressive growth in biofuel production could “crowd out” production of food crops in some developing countries, creating a tension between the need for energy and the need for food and feed. This brief investigates the interaction between crop demand for biofuel feedstock and the demand and production of crops for both food and feed, in order to see how scenarios for projected growth in biofuel production could affect food availability, prices, and consumption at global and regional levels between now and 2020. " from Text
Species of Political Parties

While the literature already includes a large number of party typologies, they are increasingly incapable of capturing the great diversity of party types that have emerged worldwide in recent decades, largely because most typologies were based upon West European parties as they existed in the late nineteenth through mid-twentieth centuries. Some new party types have been advanced, but in an ad hoc manner and on the basis of widely varying and often inconsistent criteria. This article is an effort to set many of the commonly used conceptions of parties into a coherent framework, and to delineate new party types whenever the existing models are incapable of capturing important aspects of contemporary parties. We classify each of 15 ‘species’ of party into its proper ‘genus’ on the basis of three criteria: (1) the nature of the party’s organization (thick/thin, elite-based or mass-based, etc.); (2) the programmatic orientation of the party (ideological, particularistic-clientele-oriented, etc.); and (3) tolerant and pluralistic (or democratic) versus proto-hegemonic (or anti-system). While this typology lacks parsimony, we believe that it captures more accurately the diversity of the parties as they exist in the contemporary democratic world, and is more conducive to hypothesistesting and theory-building than others.
Pose-robust albedo estimation from a single image

We present a stochastic filtering approach to perform albedo estimation from a single non-frontal face image. Albedo estimation has far reaching applications in various computer vision tasks like illumination-insensitive matching, shape recovery, etc. We extend the formulation proposed in [3] that assumes face in known pose and present an algorithm that can perform albedo estimation from a single image even when pose information is inaccurate. 3D pose of the input face image is obtained as a byproduct of the algorithm. The proposed approach utilizes class-specific statistics of faces to iteratively improve albedo and pose estimates. Illustrations and experimental results are provided to show the effectiveness of the approach. We highlight the usefulness of the method for the task of matching faces across variations in pose and illumination. The facial pose estimates obtained are also compared against ground truth.
Dissociable Contributions of Prefrontal and Parietal Cortices to Response Selection

The ability to select between possible responses to a given situation is central to human cognition. The goal of this study was to distinguish between brain areas representing candidate responses and areas selecting between competing response alternatives. Event-related fMRI data were acquired while 10 healthy adults performed a task used to examine response competition: the Eriksen flanker task. Left parietal cortex was activated by either of two manipulations that increased the need to maintain a representation of possible responses. In contrast, lateral prefrontal and rostral anterior cingulate cortices were specifically engaged by the need to select among competing response alternatives. These findings support the idea that parietal cortex is involved in activating possible responses on the basis of learned stimulus-response associations, and that prefrontal cortex is recruited when there is a need to select between competing responses.
Reference-Dependent Preferences : Models and Experiments

In economic situations people form expectations prior to their decisions. These expectations represent a reference point and exert a strong influence on decision making and preferences. This paper surveys the theory of referencedependent preferences. I will summarize the theoretical framework and present experimental evidence in support of preferences being reference-dependent. Additionally, I will address the still open and fundamental questions of how expectations are formed. That is: How are reference points formed?
TWO BRIGHT SUBMILLIMETER GALAXIES IN A z = 4.05 PROTOCLUSTER IN GOODS-NORTH, AND ACCURATE RADIO-INFRARED PHOTOMETRIC REDSHIFTS

We present the serendipitous discovery of molecular gas CO emission lines with the IRAM Plateau de Bure interferometer coincident with two luminous submillimeter galaxies (SMGs) in the Great Observatories Origins Deep Survey North (GOODS-N) field. The identification of the millimeter emission lines as CO[4–3] at z = 4.05 is based on the optical and near-IR photometric redshifts, radio-infrared photometric redshifts, and Keck+DEIMOS optical spectroscopy. These two galaxies include the brightest submillimeter source in the field (GN20; S850 μm = 20.3 mJy, zCO = 4.055 ± 0.001) and its companion (GN20.2; S850 μm = 9.9 mJy, zCO = 4.051 ± 0.003). These are among the most distant submillimeter-selected galaxies reliably identified through CO emission and also some of the most luminous known. GN20.2 has a possible additional counterpart and a luminous active galactic nucleus inside its primary counterpart revealed in the radio. Continuum emission of 0.3 mJy at 3.3 mm (0.65 mm in the rest frame) is detected at 5σ for GN20, the first dust continuum detection in an SMG at such long wavelength, unveiling a spectral energy distribution that is similar to local ultra luminous IR galaxies. In terms of CO to bolometric luminosities, stellar mass, and star formation rates (SFRs), these newly discovered z > 4 SMGs are similar to z ∼ 2–3 SMGs studied to date. These z ∼ 4 SMGs have much higher specific star formation rates than those of typical B-band dropout Lyman break galaxies at the same redshift. The stellar mass–SFR correlation for normal galaxies does not seem to evolve much further, between z ∼ 2 and z ∼ 4. A significant z = 4.05 spectroscopic redshift spike is observed in GOODS-N, and a strong spatial overdensity of B-band dropouts and IRAC selected z > 3.5 galaxies appears to be centered on the GN20 and GN20.2 galaxies. This suggests a protocluster structure with total mass ∼1014 M☉. Using photometry at mid-IR (24 μm), submillimeter (850 μm), and radio (20 cm) wavelengths, we show that reliable photometric redshifts (Δz/(1 + z) ∼ 0.1) can be derived for SMGs over 1 ≲ z ≲ 4. This new photometric redshift technique has been used to provide a first estimate of the space density of 3.5 < z < 6 hyper-luminous starburst galaxies, and to show that they both contribute substantially to the SFR density at early epochs and that they can account for the presence of old galaxies at z ∼ 2–3. Many of these high-redshift starbursts will be within reach of Herschel. We find that the criterion S1.4 GHz ≳ S24 μm, coupled to optical, near-IR and mid-IR photometry, can be used to select z > 3.5 starbursts, regardless of their submillimeter/millimeter emission.
A Monetary History of the United States

Writing in the June  issue of the Economic Journal, Harry G. Johnson begins with a sentence seemingly calibrated to the scale of the book he set himself to review: “The long-awaited monetary history of the United States by Friedman and Schwartz is in every sense of the term a monumental scholarly achievement—monumental in its sheer bulk, monumental in the definitiveness of its treatment of innumerable issues, large and small . monumental, above all, in the theoretical and statistical effort and ingenuity that have been brought to bear on the solution of complex and subtle economic issues. ” Friedman and Schwartz marshaled massive historical data and sharp analytics to support the claim that monetary policy—steady control of the money supply—matters profoundly in the management of the nation’s economy, especially in navigating serious economic fluctuations. In their influential chapter , “The Great Contraction”—which Princeton published in  as a separate paperback—they address the central economic event of the century, the Depression. According to Hugh Rockoff, writing in January : “If Great Depressions could be prevented through timely actions by the monetary authority (or by a monetary rule), as Friedman and Schwartz had contended, then the case for market economies was measurably stronger. ” Milton Friedman won the Nobel Prize in Economics in  for work related to A Monetary History as well as to his other Princeton University Press book, A Theory of the Consumption Function ().
Type definitions with parameters

It has long been known that recursively defined types in a highly typed language such as Algol 68 or Pascal may be tested for structural equivalence by the same algorithm that compares finite automata [5,11]. Several authors (for example, [3,8,9,16]) have proposed that classes of types be simultaneously defined by the use of parameterized type definitions, such asType list(x) = record val:x; next:↑list(x) end . This paper shows that unless the use of such parameterized definitions is restricted, new (unparameterized) types may be defined which more closely resemble deterministic context-free languages. In fact, the equivalence problem for such types becomes as hard as the (currently unsolved) deterministic pushdown automaton equivalence problem. Several restrictions on type definitions are considered which allow known equivalence algorithms to be applied.
Public Voting and Prosocial Behavior

Abstract One argument against secret ballots is that such procedures lead to more selfish voting behavior and that public voting can increase prosocial voting and the likelihood of prosocial outcomes when voters are not subject to intimidation and coercion from outside interests. We investigate this supposition as well as voter preferences over observability in voting in this context. We find that voters are significantly more likely to choose unselfishly when voting is public. These differences in behavior advantage prosocial choices in elections (by 27%) when voting is public. Moreover, voters appear to recognize these differences and a substantial minority of voters whose selfish preference is not the prosocial choice willingly choose public voting even though the likely outcome will be costly to themselves.
Effects of cereal fiber on leptin resistance and sensitivity in C57BL/6J mice fed a high-fat/cholesterol diet

Background Cereal fiber is reported to be associated with obesity and metabolic diseases. However, whether cereal fiber improves leptin resistance and sensitivity remains unclear. Design For 24 weeks, 48 male C57BL/6J mice were randomly given a normal chow diet (Chow), high-fat/cholesterol diet (HFD), HFD with 0.8% oat fiber (H-oat) or HFD with 0.8% wheat bran fiber (H-wheat). At the end of feeding period, both the serum insulin and leptin levels were determined by ELISA kits. Western blotting was used to assess the protein expressions of the leptin receptor (LepR) and the leptin-signaling pathway in the adipose tissues. Results Our results suggested that mice fed oat or wheat bran fiber exhibited lower body weight, serum lipids, as well as insulin and leptin levels. The two cereal fibers potently increased the protein expressions of LepR in the adipose tissue. In addition, protein expressions of Janus kinase 2 (JAK2) and transcription 3 (STAT3) (induced by LepR), which enhances leptin signaling, were significantly higher and the expression of cytokine signaling-3 (SOCS3), which inhibits leptin signaling, was significantly lower in the two cereal fiber groups than in the HFD group. Conclusion Taken together, our findings suggest that cereal fiber can improve leptin resistance and sensitivity by the JAK2/STAT3 pathway in C57BL/6J mice fed a HFD; furthermore, oat fiber is more effective in the improvement of leptin sensitivity than wheat bran fiber, in this murine model.