Miracle-dz/UniFAR-FTUs huggingface dataset:
Quasi-gradient systems, modulational dichotomies, and stability of spatially periodic patterns

Extending the approach of Grillakis-Shatah-Strauss, Bronski-Johnson-Kapitula, and others for Hamiltonian systems, we explore relations between the constrained variational problem $\min_{X:C(X)=c_0} \mathcal{E}(X)$, $c_0\in \RM^r$, and stability of solutions of a class of degenerate "quasi-gradient" systems $dX/dt=-M(X)\nabla \mathcal{E}(X)$ admitting constraints, including Cahn-Hilliard equations, one- and multi-dimensional viscoelasticity, and coupled conservation law-reaction diffusion systems arising in chemotaxis and related settings. Using the relation between variational stability and the signature of $\partial c/\partial \omega \in \R^{r\times r}$, where $c(\omega)=C(X^*_\omega)\in \RM^r$ denote the values of the imposed constraints and $\omega\in \RM^r$ the associated Lagrange multipliers at a critical point $X^*_\omega$, we obtain as in the Hamiltonian case a general criterion for co-periodic stability of periodic waves, illuminating and extending a number of previous results obtained by direct Evans function techniques. More interestingly, comparing the form of the Jacobian arising in the co-periodic theory to Jacobians arising in the formal Whitham equations associated with modulation, we recover and substantially generalize a previously mysterious "modulational dichotomy" observed in special cases by Oh-Zumbrun and Howard, showing that co-periodic and sideband stability are incompatible. In particular, we both illuminate and extend to general viscosity/strain-gradient effects and multidimensional deformations the result of Oh-Zumbrun of universal modulational instability of periodic solutions of the equations of viscoelasticity with strain-gradient effects, considered as functions on the whole line. Likewise, we generalize to multi-dimensions corresponding results of Howard on periodic solutions of Cahn-Hilliard equations.
In Vitro Study of Nitric Oxide Metabolites Effects on Human Hydatid of Echinococcus granulosus

Hydatidosis is characterized by the long-term coexistence of larva Echinococcus granulosus and its host without effective rejection. Previous studies demonstrated nitric oxide (NO) production (in vivo and in vitro) during hydatidosis. In this study, we investigated the direct in vitro effects of NO species: nitrite (NO(2) (-)), nitrate (NO(3) (-)) and peroxynitrite (ONOO(-)) on protoscolices (PSCs) viability and hydatid cyst layers integrity for 24 hours and 48 hours. Our results showed protoscolicidal activity of NO(2) (-) and ONOO(-) 24 hours and 3 hours after treatment with 320 muM and 80 muM respectively. Degenerative effects were observed on germinal and laminated layers. The comparison of the in vitro effects of NO species on the PSCs viability indicated that ONOO(-) is more cytotoxic than NO(2) (-). In contrast, NO(3) (-) has no effect. These results suggest possible involvement of NO(2) (-) and ONOO(-) in antihydatic action and point the efficacy of these metabolites as scolicidal agents.
Safety and Efficacy of an Intravaginal Prebiotic Gel in the Prevention of Recurrent Bacterial Vaginosis: A Randomized Double-Blind Study

Objective. This study was performed to evaluate the efficacy and safety of a prebiotic treatment in the balance recovery of the vaginal flora in subjects previously treated for bacterial vaginosis (BV). Study Design. A randomized trial was carried out on 42 subjects with an active prebiotic group compared to a placebo group. The main evaluation criterion was the quantification of the vaginal flora measured by the Nugent score. Secondary criteria included vaginal pH and BV recurrence. Results. After 8 days of treatment, all subjects who received the prebiotic had a normal Nugent score, whereas 33% of the subjects treated with placebo had an intermediate or positive Nugent score. After 16 days of application, a normal Nugent score was maintained in all subjects treated with the prebiotic, whereas in the placebo group 24% of the subjects still had an elevated Nugent score. Moreover, the maintenance of (or reversion to) a normal flora was associated with the maintenance of (or reversion to) physiological pH values. Conclusions. The intravaginal gel treatment improves the recovery of a normal vaginal flora after the treatment of a BV episode, which should warrant a reduction in the risk of further recurrences.
Development and Validation of a Measurement to Assess College Students’ Reactions to Faculty Incivility

This study was aimed at constructing and validating a measurement to assess students’ responses to faculty incivility (FI). A mixed-method approach was implemented. A qualitative method was used to analyze responses to FI as described by college students. The results foregrounded four categories—exit, voice, loyalty, and neglect—in line with the theoretical EVLN model for describing reactions to stressful conditions (such as, but not limited to, incivility). The students’ descriptions were formulated as short items. Following the qualitative results, a quantitative method was used to validate the developed EVLN questionnaire and to assess the relationships between student characteristic variables (mainly, religious affiliation), experiences of FI (active FI and passive FI), and the four EVLN responses. Data were gathered from 744 undergraduate college students, yet only those who experienced FI to some extent were selected to assess reactions to FI. According to the structural equation modeling results, FI was positively linked solely to the exit response. In addition, the findings indicated that merely the active FI subfactor was linked to the exit factor. Interpretation of these results, their congruence within the context of the theoretical frameworks, limitations, and practical implications are discussed.
Built Environment and Physical Functioning in Hispanic Elders: The Role of “Eyes on the Street”

Background Research on neighborhood effects increasingly includes the influences of the built environment on health and social well-being. Objectives In this population-based study in a low-socioeconomic-status (SES), Hispanic neighborhood, we examined whether architectural features of the built environment theorized to promote direct observations and interactions (e.g., porches, stoops) predicted Hispanic elders’ social support and psychological and physical functioning. Methods We coded built-environment features for all 3,857 lots in the 403-block area of an urban Miami, Florida, community. We then conducted three annual assessments of social support, psychological distress, and physical functioning in a population-based sample of 273 low-SES Hispanic elders (70–100 years of age). We used structural equation modeling analytic techniques to examine hypothesized relationships between the built environment and elders’ social support, psychological distress, and physical functioning over a 3-year period. Results After controlling for age, sex, and income, architectural features of the built environment theorized to facilitate visual and social contact had a significant direct relationship with elders’ physical functioning as measured 3 years later, and an indirect relationship through social support and psychological distress. Further binomial regression analyses suggested that elders living on blocks marked by low levels of positive front entrance features were 2.7 times as likely to have subsequent poor levels of physical functioning, compared with elders living on blocks with a greater number of positive front entrance features [b = 0.99; χ2 (1 df) = 3.71; p = 0.05; 95% confidence interval, 1.0–7.3]. Conclusions Architectural features that facilitate visual and social contacts may be a protective factor for elders’ physical functioning.
Social network concordance in food choice among spouses, friends, and siblings.

OBJECTIVES We investigated whether eating behaviors were concordant among diverse sets of social ties. METHODS We analyzed the socioeconomic and demographic distribution of eating among 3418 members of the Framingham Heart Study observed from 1991 to 2001. We used a data-classification procedure to simplify choices into 7 nonoverlapping patterns that we matched with information on social network ties. We used correlation analysis to examine eating associations among 4 types of peers (spouses, friends, brothers, and sisters). Longitudinal multiple logistic regression was used to evaluate evidence for peer influences on eating. RESULTS Of all peer types, spouses showed the strongest concordances in eating patterns over time after adjustment for social contextual factors. Across all peers, the eating pattern most likely to be shared by socially connected individuals was "alcohol and snacks. " Models estimating one's current eating pattern on the basis of a peer's prior eating provided supportive evidence of a social influence process. CONCLUSIONS Certain eating patterns appeared to be socially transmissible across different kinds of relationships. These findings represent an important step in specifying the relevant social environment in the study of health behaviors to include eating.
Significant excess of early deaths after prehospital ticagrelor: The ATLANTIC trial challenge

Summary The recently published Administration of Ticagrelor in the Cath Lab or in the Ambulance for New ST Elevation Myocardial Infarction to Open the Coronary Artery (ATLANTIC) trial concluded that prehospital administration of ticagrelor in patients with acute STEMI appeared to be safe but did not improve pre-PCI coronary reperfusion. The ATLANTIC data fully support the PLATO Angiographic Substudy denying early benefit of ticagrelor, and correspond well with lack of immediate clinical benefit including the early PCI “death paradox„ in PLATO-USA patients. Finally, there were significantly (p=0.043) more deaths in early ticagrelor ATLANTIC arm (odds ratio 3.18 (1.02–9.90) challenging stent thrombosis reduction. Indeed, ATLANTIC represents an important step for our better understanding of ticagrelor, although the confirmation of the PLATO mortality wonder in an adequately powered PEGASUS (TIMI-54) to be reported in 2015 will be vital for ticagrelor future.
Embryo development of fresh ‘versus’ vitrified metaphase II oocytes after ICSI: a prospective randomized sibling-oocyte study

BACKGROUND A successful oocyte cryopreservation programme is of utmost importance where a limited number of oocytes can be inseminated per cycle, to overcome legal and ethical issues related to embryo storage, for oocyte donation programmes and for fertility preservation (especially for cancer patients). Vitrification has been recently proposed as an effective procedure for this purpose. METHODS In order to validate the effectiveness of oocyte vitrification a non-inferiority trial was started on sibling metaphase II (MII) oocytes. To demonstrate the non-inferiority based on an absolute difference of 17% in the fertilization rate per sibling oocyte, a minimum of 222 oocytes were required. After oocyte denudation, MII oocytes with normal morphology were randomly allocated to fresh ICSI insemination or to vitrification procedure. If pregnancy was not obtained a subsequent ICSI cycle was performed with warmed oocytes of the same cohort. In both groups, three oocytes were inseminated per cycle by ICSI procedure. Primary end-points were fertilization rates calculated per warmed and per injected oocytes. Secondary end-points were zygote and embryo morphology. RESULTS A total of 244 oocytes were involved in this study. Of the 120 fresh sibling oocytes inseminated, 100 were fertilized (83.3%). Survival rate of sibling vitrified oocytes was 96.8% (120/124 oocytes). Fertilization rate after ICSI was 76.6% (95/124) per warmed oocyte and 79.2% (95/120) per survived/inseminated oocyte. No statistical difference in fertilization rates was observed between the two groups when calculated per sibling oocytes (absolute difference −6.73%; OR: 0.65; 95% CI = 0.33–1.29; P = 0.20) and per inseminated oocyte (absolute difference −4.17%; OR: 0.76; 95% CI = 0.37–1.53; P = 0.50). Embryo development was also similar in both treatment groups up till Day 2. The percentage of excellent quality embryos was 52.0% (52/100) in the fresh group and 51.6% (49/95) in the vitrification group (absolute difference −0.43%; OR: 0.98; 95% CI = 0.53–1.79; P = 0.9). The mean age of the 40 patients included in this study was 35.5 ± 4.8 years (range 26–42). Fifteen clinical pregnancies were obtained in the vitrification cycles of 39 embryo transfers performed (37.5% per cycle, 38.5% per embryo transfer), with an implantation rate of 20.2% (19/94). Three spontaneous miscarriages occurred (20%). Twelve pregnancies are ongoing (30.0% per cycle, 30.8% per embryo transfer) beyond 12 weeks of gestation. CONCLUSIONS Our results indicate that oocyte vitrification procedure followed by ICSI is not inferior to fresh insemination procedure, with regard to fertilization and embryo developmental rates. Moreover, ongoing clinical pregnancy is compatible with this procedure, even with a restricted number of oocytes available for insemination. The promising clinical results obtained, in a population of infertile patients, need to be confirmed on a larger scale. Clinical Trials Registration number: iSRCTN60158641.
Scaling and power-laws in ecological systems

SUMMARY Scaling relationships (where body size features as the independent variable) and power-law distributions are commonly reported in ecological systems. In this review we analyze scaling relationships related to energy acquisition and transformation and power-laws related to fluctuations in numbers. Our aim is to show how individual level attributes can help to explain and predict patterns at the level of populations that can propagate at upper levels of organization. We review similar relationships also appearing in the analysis of aquatic ecosystems (i.e. the biomass spectra) in the context of ecological invariant relationships (i.e. independent of size) such as the `energetic equivalence rule' and the `linear biomass hypothesis'. We also discuss some power-law distributions emerging in the analysis of numbers and fluctuations in ecological attributes as they point to regularities that are yet to be integrated with traditional scaling relationships and which we foresee as an exciting area of future research.
Action-reaction learning : analysis and synthesis of human behaviour

We propose Action-Reaction Learning as an approach for analyzing and synthesizing human behaviour. This paradigm uncovers causal mappings between past and future events or between an action and its reaction by observing time sequences. We apply this method to analyze human interaction and to subsequently synthesize human behaviour. Using a time series of perceptual measurements, a system automatically uncovers a mapping between gestures from one human participant (an action) and a subsequent gesture (a reaction) from another participant. A probabilistic model is trained from data of the human interaction using a novel estimation technique, Conditional Expectation Maximization (CEM). The system drives a graphical interactive character which probabilistically predicts the most likely response to the user's behaviour and performs it interactively. Thus, after analyzing human interaction in a pair of participants, the system is able to replace one of them and interact with a single remaining user.
Scheduling issues in high-performance computing

In this paper we consider the problem of scheduling computational resources across a range of high-performance systems, from tightly coupled parallel systems to loosely coupled ones like networks of workstations and geographically dispersed meta-computing environments. We review the role of architecture issues in the choice of scheduling discipline and we present a selected set of policies that address different aspects of the scheduling problem. This discussion serves as the motivation for addressing the success of academic research in scheduling as well as its common criticisms.
Workforce issues in nursing in Queensland: 2001 and 2004.

AIM AND OBJECTIVES The aim of the study was to identify the factors having an impact upon nursing work and to use the results to inform strategic planning of the Queensland Nurses Union. BACKGROUND In 2001 and 2004, a study was undertaken to gather data on the level of satisfaction of nurses with their working life. This paper reports the 2004 results on workload, skill mix, remuneration and morale. Where applicable, the results are compared with 2001 data. METHODS A questionnaire was mailed to 3000 Assistants-in-Nursing, Enrolled and Registered Nurses in October 2004. All participants were members of the Queensland Nurses Union. The results are reported in three sectors - public, private and aged care. A total of 1349 nurses responded to the survey, a response rate of 45%. RESULTS Nurses in the 2004 study believed: their workload was heavy; their skills and experience poorly rewarded; work stress was high; morale was perceived to be poor and, similar to 2001, deteriorating; the skill mix was often inadequate; and the majority of nurses were unable to complete their work in the time available. Nursing morale was found to be associated with autonomy, workplace equipment, workplace safety, teamwork, work stress, the physical demand of nursing work, workload, rewards for skills and experience, career prospects, status of nursing and remuneration. CONCLUSIONS Overall the findings of the study are consistent with those determined by the 2001 survey. RELEVANCE TO CLINICAL PRACTICE The findings of this study indicate the importance of factors such as workplace autonomy, teamwork, the levels of workplace stress, workload and remuneration on nursing morale. The data also indicate that workplace safety and workplace morale are linked. These findings provide information for policy makers and nurse managers on areas that need to be addressed to retain nurses within aged care, acute hospital and community nursing.
The number of retrieved lymph nodes needed for accurate staging differs based on the presence of preoperative chemoradiation for rectal cancer

AbstractThe aim of this study is to investigate if retrieval of 12 lymph nodes (LNs) is sufficient to avoid stage migration as well as to evaluate the prognostic impact of insufficient LN retrieval in different treatment settings of rectal cancer, particularly in the case of preoperative chemoradiotherapy (pCRT). The data of all patients with biopsy proven rectal adenocarcinoma who underwent curative surgery between January 2005 and December 2012 were analyzed. Univariate and multivariate analyses for oncologic outcomes were performed in LN metastasis or no LN metastasis (LN−) group. Subgroup analyses were performed according to whether a patient had received pCRT.A total of 1825 patients were enrolled into the study. The maximal Chi-square method revealed the minimum number of harvested LNs required to be 12. Univariate and multivariate analyses found LNs ≥ 12 to be an independent prognostic factor for both overall survival (OS) (hazard ratio [HR] = 0.5, 95% confidence intervals [CIs]: 0.3–0.8; P = 0.002) and disease-free survival (DFS) (HR = 0.6, 95% CI: 0.4–0.7; P < 0.001) in the LN− group. In the LN− group, LNs ≥ 12 continued to be a significant prognostic factor both for OS and DFS in the subgroup of patients who did not undergo pCRT. However, in the subgroup of the LN− patients who underwent pCRT, LN ≥ 8 was significant for DFS and OS.Retrieval of LNs ≥ 12 and LNs ≥ 8 should be achieved to obtain accurate staging and optimal treatment for the non-pCRT and pCRT groups in rectal cancer, respectively.
AMPA Receptor Facilitation Accelerates Fear Learning without Altering the Level of Conditioned Fear Acquired

Rats treated with the AMPA receptor-facilitating drug 1-(quinoxolin-6-ylcarbonyl)piperidine (BDP-12) during training acquired fear conditioning to a tone faster than vehicle-treated controls. The effect on acquisition was dependent on the dose given. BDP-12-treated rats and vehicle-treated controls reached the same level of conditioned fear and extinguished at the same rate. The dissociation of learning rate from these other normally covariant measures suggests that the drug had a specific and isolated effect on acquisition. Controls for drug effects on stimulus sensitivity, locomotor activity, generalized fearfulness, and other performance factors support this interpretation. The known action of BDP-12 on receptor dynamics suggests that its effect on acquisition may be attributed to specific modulation of an AMPA and NMDA receptor-dependent plasticity mechanism. The finding that the drug accelerates acquisition but does not affect the level of conditioned fear acquired parallels the effect of the drug on long-term potentiation (LTP) (increasing the rate but not the ceiling of potentiation) and suggests that common mechanisms may underlie fear conditioning and LTP.
Impact of different infliximab dose regimens on treatment response and drug survival in 462 patients with psoriatic arthritis: results from the nationwide registries DANBIO and ICEBIO.

OBJECTIVE The aim of this study was to describe dose regimens, dose escalation and clinical outcomes in TNF-α inhibitor (TNFi)-naive patients with PsA treated with infliximab in routine rheumatology care. METHODS We conducted an observational cohort study based on the nationwide Danish Rheumatologic Database (DANBIO) and Center for Rheumatology Research (ICEBIO) registries. Stratified by country, characteristics of patients treated with ≤3 mg infliximab/kg body weight, 3-5 mg/kg or ≥5 mg/kg every 8 weeks were described. Outcomes were evaluated by ACR 20%, 50% and 70% (ACR20/50/70) responses and European League Against Rheumatism good response after 6 months, disease activity after 12 months, Kaplan-Meier plots and regression analyses. RESULTS Four hundred and sixty-two patients (376 Danish, 86 Icelandic) received treatment with infliximab. In Danish patients, the starting dose was ≤3 mg/kg in 110 patients (29%), 3-5 mg/kg in 157 (42%), ≥5 mg/kg in 38 (10%) and unregistered in 71 (19%). In Icelandic patients, corresponding numbers were 64 (74%), 17 (27%), 0 (0%) and 5 (6%). Patients with a higher body weight received lower doses per kilogram. Danish patients received higher doses than Icelandic patients at baseline [median 3.1 (interquartile range 3.0-3.8) vs 2.3 (2.1-2.9) mg/kg, P < 0.05] and after 12 months [3.3 (3.0-4.5) vs 2.9 (2.2-3.5) mg/kg, P < 0.0001]. After 12 months, 58% of Danish and 66% of Icelandic patients maintained treatment. Danish patients had shorter drug survival than Icelandic patients (1183 vs 483 days). In univariate analyses stratified by country, time until dose escalation, response rates, drug survival and 1-year's disease activity were independent of starting dose. Drug survival was shorter among patients not receiving concomitant MTX. CONCLUSION In clinical practice, > 70% of Icelandic and Danish PsA patients treated with infliximab received sustained doses below the 5 mg/kg every 8 weeks recommended in international guidelines. Lower starting doses did not affect drug survival or response.