Miracle-dz/UniFAR-FTUs huggingface dataset:
Integrated Annotation for Biomedical Information Extraction

We describe an approach to two areas of biomedical information extraction, drug development and cancer genomics. We have developed a framework which includes corpus annotation integrated at multiple levels: a Treebank containing syntactic structure, a Propbank containing predicate-argument structure, and annotation of entities and relations among the entities. Crucial to this approach is the proper characterization of entities as relation components, which allows the integration of the entity annotation with the syntactic structure while retaining the capacity to annotate and extract more complex events. We are training statistical taggers using this annotation for such extraction as well as using them for improving the annotation process.
Effects of Ethanol Addition on the Efficiency of Subcritical Water Extraction of Proteins and Amino Acids from Porcine Placenta

In a previous study, hydrolysates of porcine placenta were obtained and the extraction efficiency for proteins and amino acids was compared between sub- and super-critical water extraction systems; optimum efficiency was found to be achieved using subcritical water (170℃, 10 bar). In this study, the effects of adding ethanol to the subcritical water system were investigated. The lowest-molecular-weight extraction product detected weighed 434 Da, and the efficiency of extraction for low-molecular-weight products was increased when either the concentration of ethanol was decreased, or the extraction time was lengthened from 10 min to 30 min. The highest concentration of free amino acids (approximately 8 mM) was observed following 30 min extraction using pure distilled water. The concentration of free amino acids was significantly lower when ethanol was added or a shorter extraction time was used (p<0.05). Color change of the solution following extraction was measured. There were no significant differences in color between lysates produced with different extraction times when using distilled water (p>0.05); however, using different extraction times produced significant differences in color when using 20% or 50% ethanol solution for subcritical extraction (p<0.05). The range of pH for the hydrolysate solutions was 6.4-7.5. In conclusion, the investigated extraction system was successful in the extraction of ≤ 500 Da hydrolysates from porcine placenta, but addition of ethanol did not yield higher production of low-molecular-weight hydrolysates than that achieved by DW alone.
Predictors of public and private healthcare utilization and associated health system responsiveness among older adults in Ghana

ABSTRACT Background: Previous studies investigating factors associated with healthcare utilization by older Ghanaians lack distinction between public and private health services. The present study examined factors associated with public and private healthcare service use, and the resulting perceived health system responsiveness. Objectives: To identify factors associated with public and private healthcare utilization among older adults aged 50 and older in Ghana; and to compare perceived differences in health system responsiveness between the private and public sectors. Methods: Cross-sectional data was analyzed from the World Health Organization Study on global AGEing and adult health (SAGE) Wave 1 in Ghana. Using Andersen’s conceptual framework, public and private outpatient care utilization was examined using multinomial logistic regression to estimate and identify predictor variables associated with the type of outpatient healthcare facility accessed. Health system responsiveness was compared using chi-square tests. Results: Of 2517 respondents who used outpatient care in the 12 months preceding interview, 51.7% of respondents used a public facility, 17.8% a private facility, and 30.5% used other facilities. Older age group, higher education and higher wealth were associated with the use of private outpatient healthcare services. Using public outpatient care facilities was associated with having health insurance. Respondents with two or more chronic conditions were more likely to use public and private outpatient care than other facilities. Perceived health system responsiveness was better in private for-profit than in public and private not-for-profit healthcare facilities. Conclusions: This study suggested that higher wealth and multimorbidity were significant predictors of public and private outpatient healthcare utilization; however, health insurance was a predictor only for the use of public facilities. Future mixed-method studies could further elucidate factors influencing the choice of public and private outpatient healthcare use.
The Dynamic Formation of Prominence Condensations

We present simulations of a model for the formation of a prominence condensation in a coronal loop. The key idea behind the model is that the spatial localization of loop heating near the chromosphere leads to a catastrophic cooling in the corona. Using a new adaptive grid code, we simulate the complete growth of a condensation and find that after ~5000 s it reaches a quasi-steady state. We show that the size and growth time of the condensation are in good agreement with data and discuss the implications of the model for coronal heating and for observations of prominences and the surrounding corona.
The Akt Proto-oncogene Links Ras to Pak and Cell Survival Signals*

The Ras oncogene regulates cellular proliferation, differentiation, transformation, and survival through multiple downstream signals. Ras signals through its effector phosphoinositide 3 (PI3) kinase to the Pak protein kinase (p65 pak ), but the steps from Ras to Pak remain to be elucidated. PI3 kinase can stimulate the small G protein, Rac, a direct activator of Pak, as well as the Akt proto-oncogene, a serine-threonine protein kinase. We found that activated Akt stimulated Pak, whereas a dominant negative Akt inhibited Ras activation of Pak in transfection assays. Akt stimulation of Pak was not inhibited by dominant negative mutants of either Rac or Cdc42 suggesting that Akt activated Pak through a GTPase-independent mechanism. We also developed a novel cell-free system to study Ras activation of Pak. In this system Ras activated Pak only in the presence of a crude cell extract but failed to activate Pak when Akt was immunodepleted from the extract. Akt protects cells from apoptosis through phosphorylation of downstream targets such as the Bcl-2 family member, Bad. We found that activated Pak decreased apoptosis and increased phosphorylation of Bad, whereas dominant negative Pak increased apoptosis and decreased phosphorylation of Bad. These studies define a new oncogene-mediated cell survival signal.
Copy-Move Forgery Detection Based on SVD in Digital Image

Identifying the authenticity and integrity of digital images becomes increasingly important in digital forensics. In this paper, we propose an effective method for detecting Copy- Move forgery. This method is implemented by first extracting SV features, which are invariant to algebraic, geometric changes, and some disturbances. Due to similar texture characteristic between copied and pasted regions, each SV feature vector is represented as a query and is then matched to its nearest neighbors in image. Experiments are provided to demonstrate the efficiency of presented method on different forgeries and evaluate its robustness and sensitivity to tampered images with some post image processing.
Water storage and subglacial drainage conditions inferred from borehole measurements on Gornergletscher, Valais, Switzerland

Abstract Measurements of change in length of a borehole, or displacements of poles and of subglacial Water pressure were combined with drainage tests and electrode tests in boreholes, in experiments near the northern margin of Gornergletscher, Valais, Switzerland, at the upstream side of an overdeepening. The measurements suggest that the subglacial drainage system consisted of discrete conduits at that location, presumably linked cavities on “clean” bedrock. Changes in subglacial water pressure were followed by variations in subglacial water storage, together with similar variations in elevation of a pole. The variations in subglacial water storage caused changes in cross-sections of subglacial passageways and thereby changed the frequencies of slug-test oscillations. Similar experiments conducted near the center line of the glacier revealed different subglacial conditions: impeded drainage through a sediment layer, and different depths of water levels in different boreholes. These results are discussed in relation to previous studies.
Brain differences between bilinguals of differing proficiency: an empirical look at an emotional issue.

Difficulty with acquiring a second language is not by any stretch of the imagination an illness. Yet in some communities where social and political pressures to achieve proficiency in the mother tongue exist, those who are not facile in language acquisition experience suffering not dissimilar to what persons with a chronic illness experience: emotional pain, a sense of deficiency, restriction of access to educational and sometimes, career opportunities. Politicians and parents alike may argue the case for and against expecting children to be bilingual but in many instances, emotive arguments have been raised without the support of empirical evidence. If it is truly a more thoughtful society we wish to build and one where reason serves to guide action more than emotion, it behooves us to study the brain, the source of our ability to acquire language. My laboratory has been involved in the characterisation of the bilingual brain for several years (1-5). One of our goals was to seek clues as to why, despite being immersed in the same environment, some individuals have difficulty acquiring a second language even though they have an excellent command of their first language. Several lines of evidence suggest that phonological working memory (PWM) plays a crucial role in determining language acquisition ability (6). Working memory is a psychological construct based on observations on short-term memory. It refers to a short-term capacity limited system whose contents are organised into phonological and visuo-spatial sections. While there are many criticisms of this construct, it has motivated memory research in a resounding manner over the years and a credible alternative platform to study short-term memory that has broad-based appeal has yet to emerge. Previous theoretical and behavioural work points to the existence of two dissociable components in PWM: a subvocal rehearsal system and a short-term phonological store. Functional imaging results suggest that the subvocal rehearsal system is located in Broca's area (Brodmann's area (BA) 44), left premotor cortex (BA 6) and supplementary motor area (BA 6) whereas the phonological store resides in the left inferior parietal cortex (BA 40) (7,8). The obligatory role of the frontal opercular areas in phonological processing has been recently demonstrated using repetitive transcranial magnetic stimulation (rTMS) (9). PWM is thought to temporarily store unfamiliar sound patterns, while more permanent representations are being constructed for long-term memory storage (6). In support of these postulates, a number of behavioural studies have shown that measures …
A Benchmark Dataset for SSVEP-Based Brain–Computer Interfaces

This paper presents a benchmark steady-state visual evoked potential (SSVEP) dataset acquired with a 40-target brain– computer interface (BCI) speller. The dataset consists of 64-channel Electroencephalogram (EEG) data from 35 healthy subjects (8 experienced and 27 naïve) while they performed a cue-guided target selecting task. The virtual keyboard of the speller was composed of 40 visual flickers, which were coded using a joint frequency and phase modulation (JFPM) approach. The stimulation frequencies ranged from 8 Hz to 15.8 Hz with an interval of 0.2 Hz. The phase difference between two adjacent frequencies was $0.5\pi $ . For each subject, the data included six blocks of 40 trials corresponding to all 40 flickers indicated by a visual cue in a random order. The stimulation duration in each trial was five seconds. The dataset can be used as a benchmark dataset to compare the methods for stimulus coding and target identification in SSVEP-based BCIs. Through offline simulation, the dataset can be used to design new system diagrams and evaluate their BCI performance without collecting any new data. The dataset also provides high-quality data for computational modeling of SSVEPs. The dataset is freely available from http://bci.med.tsinghua.edu. cn/download.html.
Ground Ultra-Low Volume Adulticiding Field Trials Using Pyrethroids Against Aedes albopictus in the Baix Llobregat Region, Spain

Abstract Ground ultra-low volume (ULV) application against Aedes albopictus is a challenging methodology as its efficacy is strongly related to environmental conditions, insect behavior, and the pesticide formulation. Such operations are very relevant in many control programs, although their real efficacy is often unknown. Trials were carried out as part of real-world applications in urban scenarios in the Baix Llobregat region to evaluate the efficacy of 2 active ingredients, delatamethrin and alpha-cypermethrin. Both pyrethroids were tested against caged mosquitoes placed at a range of distances and under varying environmental conditions. Additionally, persistence on plants placed at the same distances was evaluated after 5 h, as well as droplet distribution using water-sensitive papers. The deltamethrin formulation used yielded significantly higher 24-h mortality than alpha-cypermethrin (100% direct mortality up to 25 m versus 10 m; and 73.9% residual 5-h mortality at 20 m compared to <50% at 5 m). The influence of environmental factors, a comparison with other field tests, and the real effect on uncaged mosquitoes is discussed.
Effect of L-ascorbic Acid on the hsp70 Expression and Tissue Damage in the Third Instar Larvae of Transgenic Drosophila melanogaster (hsp70-lacZ) Bg9

All living organisms respond to various physical or chemical stressors by the induction of heat shock protein (HSP). The present study was performed on transgenic Drosophila melanogaster (hsp70-lacZ) Bg 9 in which the transformation vector is inserted with a P-element, the line contains wild-type hsp70 sequence up to the lacZ fusion point. The effect of L-ascorbic acid on the hsp70 expression and tissue damage was studied at the doses of 1, 2, 4, and 8 × 10 -4 g/ml in the third instar larvae of transgenic D. melanogaster (hsp70-lacZ) Bg 9. The larvae were exposed to different doses of L-ascorbic acid for 24 and 48 hours. A dose-dependent significant increase in the hsp70 expression was observed at 2, 4, and 8 × 10 -4 g/ml of L-ascorbic acid for both 24 and 48 hours. The tissue damage was observed only in the 48 hours of exposure and mostly only in the salivary glands of the third instar larvae of transgenic D. melanogaster (hsp70-lacZ) Bg 9 . The present study also validates and supports the use of transgenic D. melanogaster (hsp70-lacZ) Bg 9 for the toxicological evaluations.
Functional coverage driven test generation for validation of pipelined processors

Functional verification of microprocessors is one of the most complex and expensive tasks in the current system-on-chip design process. A significant bottleneck in the validation of such systems is the lack of a suitable functional coverage metric. The paper presents a functional coverage based test generation technique for pipelined architectures. The proposed methodology makes three important contributions. First, a general graph-theoretic model is developed that can capture the structure and behavior (instruction-set) of a wide variety of pipelined processors. Second, we propose a functional fault model that is used to define the functional coverage for pipelined architectures. Finally, test generation procedures are presented that accept the graph model of the architecture as input and generate test programs to detect all the faults in the functional fault model. Our experimental results on two pipelined processor models demonstrate that the number of test programs generated by our approach to obtain a fault coverage is an order of magnitude less than those generated by traditional random or constrained-random test generation techniques.
Age-related Neural Changes during Memory Conjunction Errors

Human behavioral studies demonstrate that healthy aging is often accompanied by increases in memory distortions or errors. Here we used event-related fMRI to examine the neural basis of age-related memory distortions. We used the memory conjunction error paradigm, a laboratory procedure known to elicit high levels of memory errors. For older adults, right parahippocampal gyrus showed significantly greater activity during false than during accurate retrieval. We observed no regions in which activity was greater during false than during accurate retrieval for young adults. Young adults, however, showed significantly greater activity than old adults during accurate retrieval in right hippocampus. By contrast, older adults demonstrated greater activity than young adults during accurate retrieval in right inferior and middle prefrontal cortex. These data are consistent with the notion that age-related memory conjunction errors arise from dysfunction of hippocampal system mechanisms, rather than impairments in frontally mediated monitoring processes.
Older Single Gay Men’s Body Talk: Resisting and Rigidifying the Aging Discourse in the Gay Community

ABSTRACT Previous research saw older gay men as subject to structural marginalization of ageism but yet possessing agency to interpret aging in diverse ways. I move beyond this duality, drawing on the theory of defensive othering to understand how older gay men live with the aging discourse in the gay community. Informed by grounded theory, I analyzed interviews with 25 self-identified single gay men aged 50 or above in England inductively. It emerged that many older gay men found it difficult to escape the discourse that marginalizes the aging body. Even when they argued they were the exception and “looked good,” they were discursively producing a two-tier system: they themselves as the “good older gay men,” as opposed to the other “bad older gay men,” who “had given up. ” Such a defensive othering tactic seemingly allowed them to resist age norms from applying to them personally, but unintentionally reinforced an ageist discourse.
A novel function for the Caenorhabditis elegans torsin OOC-5 in nucleoporin localization and nuclear import

Mutation in the human AAA+ protein torsinA leads to DYT1 dystonia. Loss of a Caenorhabditis elegans torsin, OOC-5, leads to defects in nucleoporin localization and nuclear import, a novel phenotype for a torsin mutant. NE ultrastructural defects similar to those in mouse and fly torsin mutants are also found, showing conservation of function.
In Vivo Studies Evaluating the Use of Contact Lenses for Drug Delivery

ABSTRACT This review highlights the current state of knowledge of in vivo testing of drug-delivering contact lenses. There has been a significant increase in interest in alternative means to deliver ocular pharmaceuticals, and within the past few decades, contact lenses have emerged as a vehicle of interest because of their biocompatibility and acceptance by both eye care professionals and the public. Using techniques such as molecular imprinting, vitamin E diffusion barriers, ionic reservoirs, and drug-impregnated films, significantly improved drug release kinetics have been observed in vitro. Extension of these results into in vivo studies has thus far been limited but has led to evidence of the viability of this drug delivery platform by demonstrating improved drug residence time, drug penetration, and clinical outcomes when compared with conventional therapy such as eye drops. The evidence supporting these improvements has occurred in both animal models and small human trials and is presented within this review.
The prevalence and clinical significance of 18F–2‐fluoro‐2‐deoxy‐D‐glucose (FDG) uptake in the thyroid gland on PET or PET‐CT in patients with lymphoma

F18–2‐fluoro‐2‐deoxy‐D‐glucose (FDG) positron emission tomography (PET) has become a well established tool in staging and assessing therapy response in lymphoma. Incidental thyroid uptake on PET is not uncommon and can pose a diagnostic and management challenge. We retrospectively evaluate the prevalence and clinical significance of incidental FDG uptake in the thyroid gland in patients with lymphoma. 1868 lymphoma patients underwent PET and PET‐CT between August 2002 and August 2008. 52 patients (2.8%) demonstrated FDG thyroid uptake (M = 17, F = 35; mean age 63 yr). Thyroid uptake was determined as focal or diffuse, maximum standardized uptake values (SUVmax) recorded as well as SUV max ratio compared to background mediastinum activity (SUVR). Corresponding CT findings on PET‐CT were evaluated independently. Results were correlated with clinical, histopathological and imaging follow‐up. 30 (1.6%) patients had focal thyroid uptake. 16 (53%) had histological confirmation either by surgery (n = 7) or FNA under USS (n = 9). The final diagnosis was benign in 12/30 patients and malignant in 9/30. The malignancy risk for focal thyroid uptake was 30%. Five patients had intercurrent thyroid cancer (four papillary, one microinvasive follicular) and four had lymphomatous involvement. There was no significant difference between the mean sizes of benign (23.7 mm, range 12–34) and malignant nodules (23.6 mm, range 8–48). The mean SUVmax of malignant and benign nodules was 4.4 (range 1.8–10.1) and 3.2 (range 1.8–6.9) respectively with no statistically significant difference. 22 (1.2%) patients had diffuse FDG uptake in thyroid and benign aetiology was found in all with adequate follow‐up (15/22). Focal FDG thyroid uptake on PET or PET‐CT in lymphoma patients warrants further investigations. The malignancy risk is 30% either due to intercurrent thyroid cancer or lymphomatous involvement. SUVmax, SUVR and CT attenuation characteristics are not helpful in distinguishing between benign and malignant aetiologies. Diffuse thyroid uptake has a benign aetiology. Copyright © 2010 John Wiley & Sons, Ltd.
Changes in satellite‐derived spring vegetation green‐up date and its linkage to climate in China from 1982 to 2010: a multimethod analysis

The change in spring phenology is recognized to exert a major influence on carbon balance dynamics in temperate ecosystems. Over the past several decades, several studies focused on shifts in spring phenology; however, large uncertainties still exist, and one understudied source could be the method implemented in retrieving satellite‐derived spring phenology. To account for this potential uncertainty, we conducted a multimethod investigation to quantify changes in vegetation green‐up date from 1982 to 2010 over temperate China, and to characterize climatic controls on spring phenology. Over temperate China, the five methods estimated that the vegetation green‐up onset date advanced, on average, at a rate of 1.3 ± 0.6 days per decade (ranging from 0.4 to 1.9 days per decade) over the last 29 years. Moreover, the sign of the trends in vegetation green‐up date derived from the five methods were broadly consistent spatially and for different vegetation types, but with large differences in the magnitude of the trend. The large intermethod variance was notably observed in arid and semiarid vegetation types. Our results also showed that change in vegetation green‐up date is more closely correlated with temperature than with precipitation. However, the temperature sensitivity of spring vegetation green‐up date became higher as precipitation increased, implying that precipitation is an important regulator of the response of vegetation spring phenology to change in temperature. This intricate linkage between spring phenology and precipitation must be taken into account in current phenological models which are mostly driven by temperature.