Miracle-dz/UniFAR-FTUs huggingface dataset:
Lost Daughters and Fragile Sons: Patterns of Differential Parental Investment Across Thirty-five Countries

Survivorship of children is unsurprisingly dependent upon numerous variables, not least of which is the role that preferential treatment plays in biasing the birth and survival of sons and daughters across cultures. This study draws upon an evolutionary approach by examining the "Trivers-Willard hypothesis" concerning condition-dependent sex allocation and differential parental investment. The central idea is that within a polygynous social mating structure – where reproductive variance is higher for males than for females as an intrinsic function of polygyny – mothers in optimal condition (defined by high status, good health, and abundant resources) are more likely to produce and invest in male offspring whereas mothers in poor condition (defined by low status, poor health, and resource deprivation) are more likely to produce and invest in female offspring so as to maximize potential lifetime reproductive success. Previous research on humans concerning this hypothesis tends to be restricted to one cultural group and thereby limited in sample size. For this study, nationally representative household survey data collected by the Demographic and Health Surveys (DHS+) program across 35 countries was used to test biological, resource-oriented, and behavioral aspects affecting maternal condition, sex allocation, and parental investment in humans. Country samples ranged from 732 to 21,839 women interviewed within South Asia, Sub-Saharan Africa, the Caribbean/Latin America, and the Near East/North Africa. The units of analysis were the mothers and their lastborn child (N = 128,039 woman-child pairs). A sequence of hierarchical regressions theoretically pre-specified a causal model concerning four constructed scales measuring maternal socioeconomic resources, maternal biological
Mechanisms of translational regulation by a human eIF5-mimic protein

The translation factor eIF5 is an important partner of eIF2, directly modulating its function in several critical steps. First, eIF5 binds eIF2/GTP/Met-tRNAiMet ternary complex (TC), promoting its recruitment to 40S ribosomal subunits. Secondly, its GTPase activating function promotes eIF2 dissociation for ribosomal subunit joining. Finally, eIF5 GDP dissociation inhibition (GDI) activity can antagonize eIF2 reactivation by competing with the eIF2 guanine exchange factor (GEF), eIF2B. The C-terminal domain (CTD) of eIF5, a W2-type HEAT domain, mediates its interaction with eIF2. Here, we characterize a related human protein containing MA3- and W2-type HEAT domains, previously termed BZW2 and renamed here as eIF5-mimic protein 1 (5MP1). Human 5MP1 interacts with eIF2 and eIF3 and inhibits general and gene-specific translation in mammalian systems. We further test whether 5MP1 is a mimic or competitor of the GEF catalytic subunit eIF2Bε or eIF5, using yeast as a model. Our results suggest that 5MP1 interacts with yeast eIF2 and promotes TC formation, but inhibits TC binding to the ribosome. Moreover, 5MP1 is not a GEF but a weak GDI for yeast eIF2. We propose that 5MP1 is a partial mimic and competitor of eIF5, interfering with the key steps by which eIF5 regulates eIF2 function.
Direct interhemispheric visual input to human speech areas

Very little is known about the connectivity of the human cerebral cortex. Nonhuman primates often serve as a model, but they are very unsatisfactory when it comes to specifically human functions. Evidence from (human) lesion and activation studies indicates that Broca's and Wernicke's areas play a critical role in language functions, whereas the inferior temporal cortex of the right hemisphere tends to be associated with high‐level visual recognition. We describe here monosynaptic interhemispheric input from the right inferior temporal cortex to Wernicke's and Broca's areas. The connections were traced in a brain with a right inferior temporal infarction by means of the Nauta method for anterogradely degenerating axons. Afferents were found both in Broca's and Wernicke's areas, with a higher density in the latter. Three organizational principles emerge from this study. First, the presence of direct connections from the right inferior temporal cortex to the speech areas indicates that human interhemispheric connections can be widely heterotopic. Second, the fact that connections from the inferior temporal cortex terminate in both Wernicke's and Broca's areas speaks in favor of parallel pathways in visuo‐verbal processing. And third, the patchy distribution of visual interhemispheric afferents in Wernicke's area hints at a possible functional compartmentalization within this area. Hum. Brain Mapping 5:347–354, 1997. © 1997 Wiley‐Liss, Inc.
Moses Illusion: Implication for Human Cognition

When asked, "How many animals did Moses take on the Ark? " most people respond, "two", even though they know that it was Noah, not Moses, who took the animals on the Ark. When a term in a sentence or a question is replaces by a semantically similar but incorrect term, people have difficulty in detecting the distortion. This tendency to overlook distortions is known as the Moses illusion.
Maxillary Central Incisor with Two Roots: A Case Report

A 16 year old female was referred to an oral and maxillofacial radiologist for evaluation of a radiolucent area at mesial radicular aspect of right maxillary central incisor which was detected accidentally during pre-orthodontic treatment check ups. Clinical examination showed no particular signs or symptoms except for slightly tenderness to lateral percussion. Second radiograph with altered horizontal angulations showed a mesial supernumerary root which the radiolucency seemed to be associated with that. In order to treat the tooth, the composite filling was removed and canals were cleaned, shaped, and obturated by lateral condensation technique.
The evolution of the luminosity functions in the FORS Deep Field from low to high redshift: I. The blue bands

We use the very deep and homogeneous I-band selected dataset of the FORS Deep Field (FDF) to trace the evolution of the luminosity function over the redshift range 0.5 < z < 5.0. We show that the FDF I-band selection down to I(AB)=26.8 misses of the order of 10 % of the galaxies that would be detected in a K-band selected survey with magnitude limit K(AB)=26.3 (like FIRES). Photometric redshifts for 5558 galaxies are estimated based on the photometry in 9 filters (U, B, Gunn g, R, I, SDSS z, J, K and a special filter centered at 834 nm). A comparison with 362 spectroscopic redshifts shows that the achieved accuracy of the photometric redshifts is (Delta z / (z_spec+1)) < 0.03 with only ~ 1 % outliers. This allows us to derive luminosity functions with a reliability similar to spectroscopic surveys. In addition, the luminosity functions can be traced to objects of lower luminosity which generally are not accessible to spectroscopy. We investigate the evolution of the luminosity functions evaluated in the restframe UV (1500 Angstroem and 2800 Angstroem), u', B, and g' bands. Comparison with results from the literature shows the reliability of the derived luminosity functions. Out to redshifts of z ~ 2.5 the data are consistent with a slope of the luminosity function approximately constant with redshift, at a value of -1.07 +- 0.04 in the UV (1500 Angstroem, 2800 Angstroem) as well as u', and -1.25 +- 0.03 in the blue (g', B). We do not see evidence for a very steep slope (alpha < -1.6) in the UV at z ~ 3.0 and z ~ 4.0 favoured by other authors. There may be a tendency for the faint-end slope to become shallower with increasing redshift but the effect is marginal. We find a brightening of M_star and a decrease of Phi_star with redshift for all analyzed wavelengths. [abridged]
Species distribution models: A comparison of statistical approaches for livestock and disease epidemics

In livestock industries, reliable up-to-date spatial distribution and abundance records for animals and farms are critical for governments to manage and respond to risks. Yet few, if any, countries can afford to maintain comprehensive, up-to-date agricultural census data. Statistical modelling can be used as a proxy for such data but comparative modelling studies have rarely been undertaken for livestock populations. Widespread species, including livestock, can be difficult to model effectively due to complex spatial distributions that do not respond predictably to environmental gradients. We assessed three machine learning species distribution models (SDM) for their capacity to estimate national-level farm animal population numbers within property boundaries: boosted regression trees (BRT), random forests (RF) and K-nearest neighbour (K-NN). The models were built from a commercial livestock database and environmental and socio-economic predictor data for New Zealand. We used two spatial data stratifications to test (i) support for decision making in an emergency response situation, and (ii) the ability for the models to predict to new geographic regions. The performance of the three model types varied substantially, but the best performing models showed very high accuracy. BRTs had the best performance overall, but RF performed equally well or better in many simulations; RFs were superior at predicting livestock numbers for all but very large commercial farms. K-NN performed poorly relative to both RF and BRT in all simulations. The predictions of both multi species and single species models for farms and within hypothetical quarantine zones were very close to observed data. These models are generally applicable for livestock estimation with broad applications in disease risk modelling, biosecurity, policy and planning.
Elasticity of sphere packings: pressure and initial state dependence

Elastic properties and internal states of isotropic sphere packings are studied by numerical simulations. Several numerical protocols to assemble dense configurations are compared. One, which imitates experiments with lubricated contacts, produces well coordinated states, while another, mimicking the effect of vibrations, results, for the same density, in a much smaller coordination number z, as small as in much looser systems. Upon varying the confining pressure P, simulations show a very nearly reversible variation of density, while z is irreversibly changed in a pressure cycle. Elastic moduli are shown to be mainly related to the coordination number. Their P dependence notably departs from predictions of simple homogenization approaches in the case of the shear moduli of poorly coordinated systems.
The problem of culture and English language teaching in Europe

This paper argues that we are still some way from developing a coherent theory of the ways in which culture and language interact and what implications such a theory might have for second language teaching. It is suggested that dominant theories of first and second language acquisition tend to treat language as though it were a culturally homogeneous phenomenon, whereas any particular language is made up of a number of different varieties each one of which expresses its own cultural meanings. Because language learners are taught a 'core' variety of the target language, they are often unaware of the cultural differences, tending instead to see the 'core' language as representative of a unified, monolithic culture. This is discussed in relation to the teaching of English within Europe, and suggestions are made as to how language teachers can remedy the situation by making pupils more aware of the cultural diversity of Britain. It is suggested that this would make the language classroom not only instrumental but also educative in function.
Age-associated molecular changes are deleterious and may modulate life span through diet

Age-associated molecular changes are deleterious and causally linked with aging and may affect life span through diet. Transition through life span is accompanied by numerous molecular changes, such as dysregulated gene expression, altered metabolite levels, and accumulated molecular damage. These changes are thought to be causal factors in aging; however, because they are numerous and are also influenced by genotype, environment, and other factors in addition to age, it is difficult to characterize the cumulative effect of these molecular changes on longevity. We reasoned that age-associated changes, such as molecular damage and tissue composition, may influence life span when used in the diet of organisms that are closely related to those that serve as a dietary source. To test this possibility, we used species-specific culture media and diets that incorporated molecular extracts of young and old organisms and compared the influence of these diets on the life span of yeast, fruitflies, and mice. In each case, the “old” diet or medium shortened the life span for one or both sexes. These findings suggest that age-associated molecular changes, such as cumulative damage and altered dietary composition, are deleterious and causally linked with aging and may affect life span through diet.
On the Evaluation of Structured Information Retrieval-Based Bug Localization on 20 C# Projects

Software projects can grow very rapidly, reaching hundreds or thousands of files in a relatively short time span. Therefore, manually finding the source code parts that should be changed in order to fix a failure is a difficult task. Static bug localization techniques provide cost-effective means of finding files related to the failure described in a bug report. Recently, structured information retrieval (IR) has been used to improve the effectiveness of static bug localization, being successfully applied by techniques such as BLUiR, BLUiR+, and AmaLgam. However, there are some significant shortcomings on how these techniques were evaluated. First, virtually all evaluations have been limited to very few projects written in only one object-oriented programming language, particularly Java. Therefore, the effectiveness of these techniques in other widely-used object-oriented languages such as C# is still unknown. Second, the experimental setup for most of the evaluations make simplistic assumptions that do not hold on real-world scenarios, thereby raising doubts about the reported effectiveness of these techniques. In this paper, we evaluate BLUiR, BLUiR+, and AmaLgam on 20 C# projects, providing a first assessment of these techniques on a previously untested object-oriented language. Moreover, we set up an experiment that addresses the simplistic assumptions commonly present in bug localization studies, thereby providing evidence on how their findings may be biased. Finally, we extend the algorithms of existing techniques in order to understand if structured information retrieval can benefit from the use of a wider range of program constructs, including C# constructs inexistent in Java.
Impact of an education intervention using email for the prevention of weight gain among adult workers

Abstract Objective To evaluate the impact of a worksite intervention to prevent weight gain among adult workers. Design A controlled community trial was performed by dividing the workers into two groups: intervention group (IG) and control group (CG). The theoretical framework applied was Intervention Mapping Protocol and the intervention was implemented through interactive software for weight self-monitoring. To evaluate the impact of the intervention, the differences in weight, BMI and waist circumference between the IG and CG were assessed before and 6 months after the intervention by regression models. Additionally, the sustainability of the intervention was evaluated at 12 months after the intervention. Settings São Paulo, Brazil. Subjects Four companies; 281 workers for the analysis of effectiveness and 427 for the analysis of sustainability. Results The intervention resulted in significant reductions in weight, BMI and waist circumference in the IG compared with the CG. The impact of the intervention on IG individuals’ body weight was −0·73 kg, while the weight of CG individuals increased. IG individuals with adequate initial weights did not show significant variations, while those who were overweight demonstrated a significant reduction in body weight. The intervention resulted in a reduction of 0·26 kg/m2 in BMI and 0·99 cm in waist circumference, and the sustainability analysis after 12 months showed a continued reduction in body weight (−0·72 kg). Conclusions The behavioural intervention was effective, resulting in weight maintenance among participants with adequate initial weight and in significant reductions among those who were overweight. More research on longer-term weight maintenance is needed.
Resources and resilience in the transition to adulthood: Continuity and change

Patterns of continuity and change in competence and resilience over the transition to adulthood were examined in relation to adversity and psychosocial resources, with a focus on adaptive resources that may be particularly important for this transition. Variable-focused and person-focused analyses drew on data from the Project Competence longitudinal study of a school cohort followed over 20 years from childhood through emerging adulthood (EA) into the young adulthood (YA) years with excellent retention (90%). Success in age-salient and emerging developmental tasks from EA to YA was examined in a sample of 173 of the original participants with complete data on adversity, competence, and key resources. Regressions and extreme-group analyses indicated striking continuity in competence and resilience, yet also predictable change. Success in developmental tasks in EA and YA was related to core resources originating in childhood (IQ, parenting quality, socioeconomic status) and also to a set of EA adaptive resources that included planfulness/future motivation, autonomy, adult support, and coping skills. EA adaptive resources had unique predictive significance for successful transitions to adulthood, both overall and for the small group of individuals whose pattern of adaptation changed dramatically from maladaptive to resilient over the transition. Results are discussed in relation to the possibility that the transition to adulthood is a window of opportunity for changing the life course.This article is based on data collected as part of the Project Competence longitudinal study, which was initiated under the leadership of Norman Garmezy, and was supported through grants to Ann Masten, Auke Tellegen, and Norman Garmezy from the William T. Grant Foundation, the National Science Foundation (SBR-9729111), the National Institute of Mental Health (MH33222), and the University of Minnesota. Preliminary results of this study were presented at the biennial meeting of the Society for Research on Adolescence in Baltimore (March 2004). The authors gratefully acknowledge the contributions to this study by the participants, who shared their lives over time to benefit others, and by the many research team members, students, and faculty, who added ideas and data to this endeavor over the years. The authors particularly want to acknowledge the role of Doug Coatsworth in designing the emerging adulthood assessments pertinent to this article and the current members of the Project Competence research team who improved this article through their thoughtful critiques and comments as the analyses and writing progressed.
Effects of Red Grape Juice Consumption on High Density Lipoprotein-Cholesterol, Apolipoprotein AI, Apolipoprotein B and Homocysteine in Healthy Human Volunteers

It has suggested that grape juice consumption has lipid- lowering effect and it is associated with a decreased risk of heart disease. We aimed to evaluate the effects of red grape juice (RGj) consumption on high density lipoprotein-cholesterol (HDL-C), apolipoprotein AI (apoAI), apolipoprotein B (apoB) and homocysteine (Hcy) levels in healthy human volunteers. Twenty six healthy and nonsmoking males, aged between 25-60 years, who were under no medication asked to consume 150 ml of RGj twice per day for one month. Serum HDL-C, apoAI, apoB and plasma Hcy levels were measured before and after one month RGj consumption. HDL-C levels after RGj consumption were significantly higher than the corresponding levels before the RGj consumption (41.44 ± 4.50 and 44.37 ± 4.30 mg/dl; P<0.0001). Also, apoB was significantly increased after RGj consumption (149.0 ± 22.35 and 157.19 ± 18.60 mg/dl; P<0.002). But apoAI levels were not changed significantly before and after of RGj consumption (154.27 ± 21.55 and 155.35 ± 21.07 mg/dl; P>0.05). Hcy levels were decreased after RGj consumption (7.70 ± 2.80 and 6.20 ± 2.30 µmol/l; P<0.001). The present study demonstrates that RGj consumption can significantly increase serum HDL-C levels and decrease Hcy levels. These findings may have important implications for the prevention of atherosclerosis in healthy individuals.
Global slab deformation and centroid moment tensor constraints on viscosity

We analyze moment tensor solutions from deep subduction zone earthquakes to determine global slab deformation patterns. Inferred strain rates are compared to predicted deformation patterns from fluid models to help constrain the first‐order radial and lateral viscosity structure of the Earth. While all slabs that reach the lower mantle are compressed at their tip, intermediate depth patterns are more complex. We compute 3‐D spherical flow with various slab rheologies and compare the angular misfit between the compressive eigenvectors of the resultant stress field and global centroid moment tensor (gCMT) solutions. We find that upper mantle slab viscosities of ∼10–100 and lower mantle viscosities of ∼30–100 times the upper mantle produce the best match to gCMTs. A 0.1 viscosity reduction in the asthenosphere seems preferred. Slab geometry and lower mantle viscosity exert significant control on deformation. Inclusion of the phase changes at 410 km and 660 km increases extensional deformation at intermediate depth and compressional deformation at the lower mantle, improving the match to gCMTs for strong slabs. Our conclusions are fairly insensitive to surface boundary conditions. However, models which include net rotations of the surface with respect to the lower mantle produce compression at intermediate depths for west directed slabs and extension for east directed slabs. Without allowing for regional variations, these models yield the best match to gCMTs. While significant deviations between model and seismicity remain, our results show that seismicity provides an underutilized constraint for slab dynamics.