Miracle-dz/UniFAR-FTUs huggingface dataset:
Serum Fucosylated Haptoglobin as a Novel Diagnostic Biomarker for Predicting Hepatocyte Ballooning and Nonalcoholic Steatohepatitis

Nonalcoholic fatty liver disease (NAFLD) is a growing medical problem around the world. NAFLD patients with nonalcoholic steatohepatitis (NASH) can develop cirrhosis and hepatocellular carcinoma. The ability to distinguish NASH from simple steatosis would be of great clinical significance. Ballooning hepatocytes are characteristic of typical pathological NASH; here, the polarized secretion of proteins is disrupted due to destruction of the cytoskeleton. We previously reported that fucosylated glycoproteins are secreted into bile, but not into sera in normal liver. Therefore, we hypothesized that the fucosylation-based sorting machinery would be disrupted in ballooning hepatocytes, and serum fucosylated glycoproteins would increase in NASH patients. To confirm our hypothesis, we evaluated serum fucosylated haptoglobin (Fuc-Hpt) levels in biopsy-proven NAFLD patients (n = 126) using a lectin-antibody ELISA kit. Fuc-Hpt levels were significantly increased in NASH patients compared with non-NASH (NAFLD patients without NASH) patients. Interestingly, Fuc-Hpt levels showed a significant stepwise increase with increasing hepatocyte ballooning scores. Multiple logistic regression analysis showed that Fuc-Hpt levels were independent and significant determinants of the presence of ballooning hepatocytes. Moreover, Fuc-Hpt levels were useful in monitoring liver fibrosis staging. Next, to investigate the significance of serum Fuc-Hpt in a larger population, we measured Fuc-Hpt levels in ultrasound-diagnosed NAFLD subjects (n = 870) who received a medical health checkup. To evaluate NAFLD disease severity, we used the FIB-4 index (based on age, serum AST and ALT levels, and platelet counts). Fuc-Hpt levels increased stepwise with increasing FIB-4 index. Conclusion Measurement of serum Fuc-Hpt levels can distinguish NASH from non-NASH patients, and predict the presence of ballooning hepatocytes in NAFLD patients with sufficient accuracy. These results support the potential usefulness of measuring Fuc-Hpt levels in clinical practice.
Escherichia coli Nissle 1917 in Ulcerative Colitis Treatment: Systematic Review and Meta-analysis.

BACKGROUND AND AIMS Escherichia coli Nissle 1917 (EcN) has been recommended as a therapeutic tool for ulcerative colitis (UC) treatment. However, to date, no meta-analysis has been performed on this topic. METHODS We performed a literature search on PubMed, MEDLINE, Science Direct and EMBASE. We evaluated success rates for induction of remission, relapse rates and side effects, expressed as Intention-To-Treat. Odd ratios (OR), pooled OR and 95% confidence intervals (CI) were calculated, based on the Mantel-Haenszel method. Heterogeneity was assessed by using the χ2 and I2 statistics and, if present, a random-effects model was adopted. RESULTS We selected six eligible trials, with 719 patients, 390 assigned to the study group and 329 to the control group. EcN induced remission in 61.6% of cases, while in the control group (mesalazine) the remission was achieved in 69.5% of cases, with a mean difference of 7.9%. The pooled OR was 0.92 (95% CI 0.15-9.66, p=0.93). A single study showed a better performance of EcN than the placebo. A relapse of the disease occurred in 36.8% in the EcN group and in 36.1% in the control group (mesalazine), with a mean difference of 0.8%, OR=1.07, with a 95% CI of 0.70-1.64 (p=0.74). Side effects were comparable (OR=1.44, 95% CI 0.80-2.59, p=0.22). CONCLUSIONS EcN is equivalent to mesalazine in preventing disease relapse, thus confirming current guideline recommendations. EcN seems to be as effective as controls in inducing remission and therefore, its use cannot be recommended as in one study the comparison was performed against placebo. Further studies may be helpful for this subject.
Renin-angiotensin System Activation in Congenital Hepatic Fibrosis in the PCK Rat Model of Autosomal Recessive Polycystic Kidney Disease

Objectives: Congenital hepatic fibrosis (CHF) is an important cause of morbidity and mortality in patients with autosomal recessive polycystic kidney disease (ARPKD). The pathogenesis of CHF remains undefined. Several recent studies suggest that the renin-angiotensin system (RAS) is an important mediator of progressive hepatic fibrosis through activation of profibrotic mediators, such as transforming growth factor-β (TGF-β). RAS activation has not previously been studied in patients with CHF or in animal models. The aim of the present study was to characterize RAS expression during the course of CHF in the PCK rat. Materials and Methods: Studies were conducted in the PCK rat, an orthologous ARPKD/CHF model, and age-matched normal control Sprague-Dawley rats. Expression of the RAS components, renin, angiotensinogen, angiotensin-converting enzyme (ACE), and angiotensin II type 1 receptor (AT1R), as well as the profibrotic mediator TGF-β, was examined in cystic PCK and control rat livers at 2, 4, and 6 months of age by quantitative real-time polymerase chain rection (qRT-PCR). Angiotensin II (ANG II) was examined by immunohistochemistry (IHC). Fibrosis was assessed by IHC using reticulin staining and Masson trichrome. Collagen content was determined by hydroxyproline analysis. Results: Progressive fibrosis and increased hepatic collagen content occurred in PCK rats with age. In 4- and 6-month-old PCK rat livers, ACE gene expression was markedly increased, 8- and 17-fold, respectively, compared with age-matched control livers. Expression of the other RAS components, renin, angiotensinogen, and AT1R were not significantly different. IHC demonstrated prominent ANG II protein expression in periportal regions in PCK rats. In contrast, no expression was noted in control livers. TGF-β expression was also increased in PCK rat livers with progressive disease. Conclusions: The present study demonstrates, for the first time, RAS upregulation in an orthologous rat ARPKD/CHF model. Increases in ACE and ANG II, as well as the downstream target, the profibrotic mediator TGF-β, suggest that RAS activation may be an important mediator of CHF disease progression. The findings also suggest that treatment with RAS inhibitors, specifically ACE inhibitors or AT1R blockers, could be therapeutic in slowing disease progression in CHF.
Revised conodont and fusuline biostratigraphy of the Bamchi Formation (Pyongan Supergroup) at the Bamchi section, Yeongwol and the Carboniferous–Permian boundary in South Korea

Wang, Q. , Wang, Y. , Qi, Y. , Wang, X. , Choh, S.J., Lee, D.C. & Lee, D.J., November 2017. Yeongwol and the Carboniferous–Permian boundary in South Korea. Alcheringa 42, 245–258. ISSN 0311-5518 Six conodont and one fusuline zones are recognized on basis of a total of 25 conodont and 13 fusuline species (including seven unidentified species or species given with cf. or aff. in total) from the Bamchi Formation, Yeongwol, Korea. The conodont zones include the Streptognathodus bellus, S. isolatus, S. cristellaris, S. sigmoidalis, S. fusus and S. barskovi zones in ascending order, which can be correlated with the conodont zones spanning the uppermost Gzhelian to Asselian Age of the Permian globally. The fusuline zone is named the Rugosofusulina complicata–Pseudoschwagerina paraborealis zone. The co-occurrence of the conodont Streptognathodus isolatus (the Global Boundary Stratotype Section and Point index for the base of Permian) and Pseudoschwagerina (a Permian inflated fusuline) indicates that the Carboniferous–Permian boundary can be placed in the lower part of the Bamchi Formation in South Korea. Qiulai Wang* [qlwang@nigpas.ac. cn] CAS Key Laboratory of Economic Stratigraphy and Palaeogeography, Nanjing Institute of Geology and Palaeontology, Chinese Academy of Sciences, East Beijing Road 39, Nanjing 210008, PR China; Yue Wang* [yuewang@nigpas.ac. cn] LPS, Nanjing Institute of Geology and Palaeontology, Chinese Academy of Sciences, East Beijing Road 39, Nanjing 210008, PR China; Yuping Qi* [ypqi@nigpas.ac. cn] Xiangdong Wang* [xdwang@nigpas.ac. cn] CAS Key Laboratory of Economic Stratigraphy and Palaeogeography, Nanjing Institute of Geology and Palaeontology, Chinese Academy of Sciences, East Beijing Road 39, Nanjing 210008, PR China; Suk-Joo Choh [sjchoh@korea.ac. kr] Department of Earth and Environmental Sciences, Korea University, Seoul 02841, Republic of Korea; Dong-Chan Lee [dclee@chungbuk.ac. kr] Department of Earth Sciences Education, Chungbuk National University, Cheongju 28644, Republic of Korea; Dong-Jin Lee [djlee@andong.ac. kr] Department of Earth and Environmental Sciences, Andong National University, Andong 36729, Republic of Korea. *Also affiliated with: University of Chinese Academy of Sciences, 19A Yuquan Road, Shijingshan District, Beijing 100049, PR China.
Optimization of Decision Support Tool using Medication Regimens to Assess Rehospitalization Risks

Summary Background: Unnecessary hospital readmissions are costly for the U.S. health care system. An automated algorithm was developed to target this problem and proven to predict elderly patients at greater risk of rehospitalization based on their medication regimens. Objective: Improve the algorithm for predicting elderly patients’ risks for readmission by optimizing the sensitivity of its medication criteria. Methods: Outcome and Assessment Information Set (OASIS) and medication data were reused from a study that defined and tested an algorithm for assessing rehospitalization risks of 911 patients from 15 Medicare-certified home health care agencies. Odds Ratio analyses, literature reviews and clinical judgments were used to adjust the scoring of patients’ High Risk Medication Regimens (HRMRs). Receiver Operating Characteristic (ROC) analysis evaluated whether these adjustments improved the predictive strength of the algorithm’s components. Results: HRMR scores are composed of polypharmacy (number of drugs), potentially inappropriate medications (PIM) (drugs risky to the elderly), and Medication Regimen Complexity Index (MRCI) (complex dose forms, dose frequency, instructions or administration). Strongest ROC results for the HRMR components were Areas Under the Curve (AUC) of . 68 for polypharmacy when excluding supplements; and . 60 for PIM and . 69 for MRCI using the original HRMR criteria. The “cut point” identifying MRCI scores as indicative of medication-related readmission risk was increased from 20 to 33. Conclusion: The automated algorithm can predict elderly patients at risk of hospital readmissions and its underlying criteria is improved by a modification to its polypharmacy definition and MRCI cut point. Citation: Olson CH, Dierich M, Adam T, Westra BL. Optimization of decision support tool using medication regimens to assess rehospitalization risks. Appl Clin Inf 2014; 5: 773–788 http://dx.doi. org/10.4338/ACI-2014-04-RA-0040
Vitamin D Metabolic Pathway Genes and Pancreatic Cancer Risk

Evidence on the association between vitamin D status and pancreatic cancer risk is inconsistent. This inconsistency may be partially attributable to variation in vitamin D regulating genes. We selected 11 vitamin D-related genes (GC, DHCR7, CYP2R1, VDR, CYP27B1, CYP24A1, CYP27A1, RXRA, CRP2, CASR and CUBN) totaling 213 single nucleotide polymorphisms (SNPs), and examined associations with pancreatic adenocarcinoma. Our study included 3,583 pancreatic cancer cases and 7,053 controls from the genome-wide association studies of pancreatic cancer PanScans-I-III. We used the Adaptive Joint Test and the Adaptive Rank Truncated Product statistic for pathway and gene analyses, and unconditional logistic regression for SNP analyses, adjusting for age, sex, study and population stratification. We examined effect modification by circulating vitamin D concentration (≤50, >50 nmol/L) for the most significant SNPs using a subset of cohort cases (n = 713) and controls (n = 878). The vitamin D metabolic pathway was not associated with pancreatic cancer risk (p = 0.830). Of the individual genes, none were associated with pancreatic cancer risk at a significance level of p<0.05. SNPs near the VDR (rs2239186), LRP2 (rs4668123), CYP24A1 (rs2762932), GC (rs2282679), and CUBN (rs1810205) genes were the top SNPs associated with pancreatic cancer (p-values 0.008–0.037), but none were statistically significant after adjusting for multiple comparisons. Associations between these SNPs and pancreatic cancer were not modified by circulating concentrations of vitamin D. These findings do not support an association between vitamin D-related genes and pancreatic cancer risk. Future research should explore other pathways through which vitamin D status might be associated with pancreatic cancer risk.
Effect of Korean red ginseng extract on liver damage induced by short-term and long-term ethanol treatment in rats

Korean red ginseng (KRG) is prepared by the process of steaming the roots of Panax ginseng. In this study, the feeding effects of KRG-water extract (KRGE) on ethanol-induced liver damage were elucidated by measuring serum biomarkers in rats. Serum γ-glutamyltranspeptidase (γ-GT) activity and the concentration of malondialdehyde (MDA) were significantly increased by short-term and long-term ethanol treatment in rats, whereas the activities of serum glutamate pyruvate transaminase (GPT) and glutamate oxaloacetate transaminase (GOT) did not respond. Pretreatment with KRGE maintained the activity of serum GPT, and the MDA concentration induced by short-term ethanol ingestion remained within the normal range. However, co-feeding of KRGE to rats decreased the concentration of MDA but failed to modulate the serum γ-GT activity induced by long-term ethanol treatment. Our studies suggest that in rats, it appears that KRGE does not sufficiently reverse the physiological response evoked by long-term ethanol ingestion to maintain normal conditions, in view of the serum biomarker γ-GT, regardless of KRGE’s favorable antioxidant activity.
Presurgical Nasoalveolar Molding and Primary Gingivoperiosteoplasty Reduce the Need for Bone Grafting in Patients with Bilateral Clefts

Abstract Preoperative nasoalveolar molding (NAM) in combination with primary gingivoperiosteoplasty (GPP) reduces the need for secondary alveolar bone grafting by 60% in patients with unilateral cleft lip and palate (CL/P). Herein, we investigate the efficacy of NAM and primary GPP in patients with bilateral CL/P. All patients (n = 38) with bilateral CL/P who underwent NAM and primary GPP from 1988 to 1998 with at least 14 years of follow-up were included in this study. Panoramic and periapical radiographs were used to assess dentoalveolar bone formation. A total of 38 patients were identified with median follow-up of 18 years (range 14–26 years). Of the 27 patients who underwent bilateral GPP, 14 (51%) patients had successful dentoalveolar bone formation bilaterally and 13 (49%) had unilateral bone formation. No patient had a bilateral failure. Of the 11 patients who underwent unilateral GPP, 7 (63%) patients had successful dentoalveolar bone formation. Bilateral successful dentoalveolar bone formation following primary bilateral GPP has a dependent probability of 52% and a conditional probability of 82%.
Hypercholesterolemia in Minipigs Impairs Left Ventricular Response to Stress: Association With Decreased Coronary Flow Reserve and Reduced Capillary Density

Background—Hypercholesterolemia induces functional and structural changes of the microvasculature and reduces coronary flow reserve in humans and experimental animals. The effect of hypercholesterolemia on left ventricular (LV) function in the absence of coronary stenosis is, however, unknown. Our objective was therefore to assess the effect of hypercholesterolemia and cholesterol withdrawal on LV function in the presence of advanced coronary plaques that do not cause stenosis. Methods and Results—Twenty-eight minipigs on cholesterol diet for 34 weeks and 16 control pigs were studied. Seven hypercholesterolemic pigs were withdrawn from the diet for 26 weeks. LV function was assessed with cine-MRI, myocardial blood flow with colored microspheres, and capillary density with immunohistochemistry, and microvascular endothelial cell apoptosis with terminal dUTP nick-end labeling staining. Hypercholesterolemia (17±8 versus 268±150 versus 12±10 mg/dL LDL cholesterol, control versus hypercholesterolemic versus cholesterol withdrawal;P <0.001) induced atherosclerosis but not stenosis in the left coronary artery. Baseline cardiac output, ejection fraction, and stroke volume were similar in control and hypercholesterolemic pigs. In dobutamine stress test, cardiac output (P <0.05) and stroke volume (P <0.01) were lower in hypercholesterolemic pigs compared with controls. The impaired response to dobutamine was reversible by dietary cholesterol withdrawal. Hypercholesterolemia reduced endomyocardial coronary flow reserve (P <0.01) and capillary density (P <0.05) and induced capillary endothelial cell apoptosis. Hypercholesterolemic pigs failed to reduce vascular resistance in response to increased LV workload and pharmacological vasodilation. Conclusion—LDL hypercholesterolemia in minipigs impaired LV response to dobutamine stress in the absence of coronary stenosis.
Two contrasting accretion v. collision orogenies: insights from Early Paleozoic polyphase metamorphism in the Altun–Qilian–North Qaidam orogenic system, NW China

Abstract The Altun–Qilian–North Qaidam (AQQ) orogenic system in northern Tibet is considered to be the northernmost orogenic collage of the Prototethyan domain. It is regarded as resulting from collisions between various continental terranes derived from the northern margin of Gondwana, although the AQQ orogenic system also includes abundant ophiolites, arc magmatic rocks and subduction–accretion complexes. Some researchers regard the orogenic system of north Tibet as a typical accretionary orogen built by the development of an evolving arc–accretion complex growing southwards along the margin of the Tarim and North China cratons during the Paleozoic. We propose, based on both published data and our new data, that two distinct accretion and collision orogenies developed in the AQQ during the early Paleozoic. The diagnostic marks are HP–LT metamorphic rocks in the North Altun–North Qilian Mountains and UHP metamorphic rocks in the South Altun–North Qaidam Mountains. A review of metamorphic, geochronological, geochemical and structural data indicates that the North Altun–North Qilian HP–LT metamorphic belt is related to early Paleozoic subduction–accretion and, together with ophiolite mélanges and arc metamorphic–magmatic complexes, forms an early Paleozoic accretionary orogen. By contrast, the South Altun–North Qaidam UHP metamorphic belt is associated with continental subduction and collision, accompanied by Barrovian-type metamorphic overprinting and collision-related magmatism, reflecting an early Paleozoic collisional orogeny.
A 0.56 THz Phase-Locked Frequency Synthesizer in 65 nm CMOS Technology

This paper presents the design and characterization of a 0.56 THz frequency synthesizer implemented in standard 65 nm CMOS technology. Its front end consists of triple-push Colpitts oscillators (TPCOs), followed by the first and second stage injection locking frequency dividers (ILFDs) and a divide-by-16 chain. TPCOs are used to triple their fundamental frequencies to 0.53-0.56 THz, while ILFDs and the subsequent divider chain are used to divide such frequencies to 2.7-2.9 GHz. Its back end consists of separate frequency and phase-locked loops with unique CMOS circuit designs to accomplish the desirable frequency/phase locking, including: 1) band-selection inductor switches; 2) simultaneous bulk voltage tuning over TPCOs and the first ILFD; and 3) a dual port injection architecture for the first ILFD. The resultant prototype realizes a 21 GHz frequency locking range with phase noise lower than -74 dBc/Hz at 1 MHz offset, and consumes 174 mW dc power.
[Comparison of pre-induction ultrasonographic cervical length and Bishop score in predicting risk of cesarean section after labor induction with prostaglandins].

OBJECTIVE To compare pre-induction ultrasonographic cervical length and Bishop score in predicting risk of caesarean section after labor induction with prostaglandins. PATIENTS AND METHODS Assessment of the Bishop score and measurement of the cervical length by transvaginal sonography were performed by two operators, blinded to each other's results among women with singleton pregnancies at between 34(+0) - 41(+3) weeks of gestation requiring induction of labor with prostaglandins for medical indications. Fisher's exact test and regression logistic models were used for statistics analysis. In order to measure the strength of the association between ultrasonographic cervical length or Bishop score on one hand, and the caesarean sections rate (global or for failed induction or failure to progress) on the other hand, we computed odds ratios with 95% confidence interval. RESULTS Among the 266 patients included in the study, multivariate analysis has shown that only Bishop score was predictive for the global caesarean section risk (OR [95% CI] 0.63 [0.45-0.87] ; P =0.005). However, neither Bishop score (OR [95% CI] 0.68 [0.42-1.09] ; P =0.11), nor ultrasonographic cervical length (OR [95% CI] 1.01 [0.95-1.08] ; P =0.59) was predictive for failed induction or failure to progress caesarean section risk. DISCUSSION AND CONCLUSION The Bishop score appears to be a better predictor of the global caesarean section risk than ultrasonographic cervical length after induction of labor for medical reasons.
Trauma histories among justice-involved youth: findings from the National Child Traumatic Stress Network

Background Up to 90% of justice-involved youth report exposure to some type of traumatic event. On average, 70% of youth meet criteria for a mental health disorder with approximately 30% of youth meeting criteria for post-traumatic stress disorder (PTSD). Justice-involved youth are also at risk for substance use and academic problems, and child welfare involvement. Yet, less is known about the details of their trauma histories, and associations among trauma details, mental health problems, and associated risk factors. Objective This study describes detailed trauma histories, mental health problems, and associated risk factors (i.e., academic problems, substance/alcohol use, and concurrent child welfare involvement) among adolescents with recent involvement in the juvenile justice system. Method The National Child Traumatic Stress Network Core Data Set (NCTSN-CDS) is used to address these aims, among which 658 adolescents report recent involvement in the juvenile justice system as indexed by being detained or under community supervision by the juvenile court. Results Age of onset of trauma exposure was within the first 5 years of life for 62% of youth and approximately one-third of youth report exposure to multiple or co-occurring trauma types each year into adolescence. Mental health problems are prevalent with 23.6% of youth meeting criteria for PTSD, 66.1% in the clinical range for externalizing problems, and 45.5% in the clinical range for internalizing problems. Early age of onset of trauma exposure was differentially associated with mental health problems and related risk factors among males and females. Conclusions The results indicate that justice-involved youth report high rates of trauma exposure and that this trauma typically begins early in life, is often in multiple contexts, and persists over time. Findings provide support for establishing trauma-informed juvenile justice systems that can respond to the needs of traumatized youth.