Miracle-dz/UniFAR-FTUs huggingface dataset:
Ambient Noise Monitoring of Seismic Velocity Around the Longmenshan Fault Zone From 10 Years of Continuous Observation

We present 10‐year continuous seismic velocity changes from 2007 to 2017 around the Longmenshan fault zone, where the 2008 Mw 7.9 Wenchuan earthquake and the 2013 Mw 6.6 Lushan earthquake occurred. We collected continuous waveforms recorded by 20 broadband stations covering the entire Longmenshan fault zone and used three‐component ambient noise correlation techniques to measure the velocity changes in four different period bands. Our results show that a significant drop, 0.04–0.06%, occurred in the coseismic velocity at the time of the Wenchuan earthquake, near the rupture zone for the period bands of 1–3 and 3–8 s. In addition, only one fourth of the coseismic velocity drop has been recovered 9 years after the earthquake. We also observed a subtle velocity drop, 0.0066%, delayed by ~100 days relative to the time of the mainshock in the period bands of 6–15 s. In the source region of the Lushan earthquake, we detected a weak but reliable coseismic velocity change of ~0.01% in the period band of 1–3 s. The physical mechanism of the seismic velocity change could involve the damage in the shallow subsurface layer (<3 km), the damage in the fault zone at depth (~10 km), and the postseismic slip along the deep rupture zone up to ~20 km. The uncommonly slow postseismic velocity recovery indicates the slow healing of the Longmenshan fault zone after the Wenchuan earthquake, which may be associated with the low rate of stress loading onto the fault zone.
A Case of Hypersensitivity Syndrome to Both Vancomycin and Teicoplanin

Drug hypersensitivity syndrome to both vancomycin and teicoplanin has not been previously reported. We describe here a 50-yr-old male patient with vertebral osteomyelitis and epidural abscess who developed hypersensitivity syndrome to both vancomycin and teicoplanin. Skin rash, fever, eosinophilia, interstitial pneumonitis, and interstitial nephritis developed following the administration of each drug, and resolved after withdrawing the drugs and treating with high dose corticosteroids. The vertebral osteomyelitis was successfully treated with 6-week course of linezolid without further complications. Skin patch tests for vancomycin and teicoplanin was done 2 months after the recovery; a weak positive result for vancomycin (10% aq.,+at D2 and +at D4 with erythema and vesicles; ICDRG scale), and a doubtful result for teicoplanin (4% aq.-at D2 and±at D4 with macular erythema; ICDRG scale). We present this case to alert clinicians to the hypersensitivity syndrome that can result from vancomycin and teicoplanin, with possible cross-reactivity, which could potentially be life-threatening.
Insect bite-like reaction in patients with hematologic malignant neoplasms.

BACKGROUND Exaggerated reaction to insect bites, mainly to mosquitoes, is infrequently described in patients with chronic lymphocytic leukemia. Skin lesions usually appear months to years after the diagnosis of leukemia and are unrelated to laboratory findings, disease course, or therapy. OBSERVATIONS We describe 8 patients with various hematologic disorders (chronic lymphocytic leukemia, acute lymphoblastic leukemia, acute monocytic leukemia, mantle-cell lymphoma, large-cell lymphoma, and myelofibrosis) who developed insect bite-like reaction. Although the clinical picture and the histological characteristics of the lesions were typical for insect bites, none of the patients actually had a history, course, or response to treatment suggestive of arthropod assaults. In 2 patients, the eruption preceded the diagnosis of the malignant neoplasm. The rash persisted for months to years and was resistant to therapies other than systemic corticosteroids. The 3 patients with chronic lymphocytic leukemia seemed to have a worse prognosis than expected for their disease. In 1, the polymerase chain reaction detected leukemic cells in the infiltrate. CONCLUSIONS Insect bite-like reaction is an infrequent, disturbing, and difficult-to-treat nonspecific phenomenon in patients with hematologic malignant neoplasms. Since it may precede the hematologic disorder, oriented evaluation is warranted. We speculate that immunodeficiency plays a role in its pathogenesis; however, the exact pathogenesis and its prognostic implications await further studies.
Human and Drosophila Homeodomain Proteins That Enhance the DNA-Binding Activity of Serum Response Factor

Cells with distinct developmental histories can respond differentially to identical signals, suggesting that signals are interpreted in a fashion that reflects a cell's identity. How this might occur is suggested by the observation that proteins of the homeodomain family, including a newly identified human protein, enhance the DNA-binding activity of serum response factor, a protein required for the induction of genes by growth and differentiation factors. Interaction with proteins of the serum response factor family may allow homeodomain proteins to specify the transcriptional response to inductive signals. Moreover, because the ability to enhance the binding of serum response factor to DNA resides within the homeodomain but is independent of homeodomain DNA-binding activity, this additional activity of the homeodomain may account for some of the specificity of action of homeodomain proteins in development.
Differential dependencies: Reasoning and discovery

The importance of difference semantics (e.g., “similar” or “dissimilar”) has been recently recognized for declaring dependencies among various types of data, such as numerical values or text values. We propose a novel form of Differential Dependencies (dds), which specifies constraints on difference, called differential functions, instead of identification functions in traditional dependency notations like functional dependencies. Informally, a differential dependency states that if two tuples have distances on attributes X agreeing with a certain differential function, then their distances on attributes Y should also agree with the corresponding differential function on Y. For example, [date(≤ 7)]→[price(< 100)] states that the price difference of any two days within a week length should be no greater than 100 dollars. Such differential dependencies are useful in various applications, for example, violation detection, data partition, query optimization, record linkage, etc. In this article, we first address several theoretical issues of differential dependencies, including formal definitions of dds and differential keys, subsumption order relation of differential functions, implication of dds, closure of a differential function, a sound and complete inference system, and minimal cover for dds. Then, we investigate a practical problem, that is, how to discover dds and differential keys from a given dataset. Due to the intrinsic hardness, we develop several pruning methods to improve the discovery efficiency in practice. Finally, through an extensive experimental evaluation on real datasets, we demonstrate the discovery performance and the effectiveness of dds in several real applications.
Correction: Morphological Evolution Is Accelerated among Island Mammals

In PLoS Biology, volume 4, issue 10: DOI: 10.1371/journal.pbio. 0040321 The legend to Figure 4 incorrectly identifies the dotted line as representing evolutionary rate and the solid line as representing the size of a morphological character. This identification is reversed in the caption. The dotted line represents the morphological trait's magnitude and the solid is the rate of evolution.
Bees associate colour cues with differences in pollen rewards

In contrast to the wealth of knowledge concerning sucrose-rewarded learning, the question of whether bees learn when they collect pollen from flowers has been little addressed. The nutritional value of pollen varies considerably between species, and it may be that bees learn the features of flowers that produce pollen best suited to the dietary requirements of their larvae. It is still unknown, however, whether a non-ingestive reward pathway for pollen learning exists, and how foraging bees sense differences between pollen types. Here we adopt a novel experimental approach testing the learning ability of bees with pollen rewards. Bumblebees were reared under controlled laboratory conditions. To establish which pollen rewards are distinguishable, individual bees were given the choice of collecting two types of pollen, diluted to varying degrees with indigestible α-cellulose. Bees preferentially collected a particular pollen type, but this was not always the most concentrated sample. Preferences were influenced by the degree of similarity between samples and also by the period of exposure, with bees more readily collecting samples of lower pollen concentration after five trials. When trained differentially, bees were able to associate an initially less-preferred contextual colour with the more concentrated sample, whilst their pollen preferences did not change. Successful learning of contextual cues seems to maintain pollen foraging preferences over repeated exposures, suggesting that fast learning of floral cues may preclude continuous sampling and evaluation of alternative reward sources, leading to constancy in pollen foraging.
Predictive factors of incomplete aneurysm occlusion after endovascular treatment with the Pipeline embolization device.

OBJECTIVEThe Pipeline embolization device (PED) is a routine choice for the endovascular treatment of select intracranial aneurysms. Its success is based on the high rates of aneurysm occlusion, followed by near-zero recanalization probability once occlusion has occurred. Therefore, identification of patient factors predictive of incomplete occlusion on the last angiographic follow-up is critical to its success.METHODSA multicenter retrospective cohort analysis was conducted on consecutive patients treated with a PED for unruptured aneurysms in 3 academic institutions in the US. Patients with angiographic follow-up were selected to identify the factors associated with incomplete occlusion.RESULTSAmong all 3 participating institutions a total of 523 PED placement procedures were identified. There were 284 procedures for 316 aneurysms, which had radiographic follow-up and were included in this analysis (median age 58 years; female-to-male ratio 4.2:1). Complete occlusion (100% occlusion) was noted in 76.6% of aneurysms, whereas incomplete occlusion (≤ 99% occlusion) at last follow-up was identified in 23.4%. After accounting for factor collinearity and confounding, multivariable analysis identified older age (> 70 years; OR 4.46, 95% CI 2.30-8.65, p < 0.001); higher maximal diameter (≥ 15 mm; OR 3.29, 95% CI 1.43-7.55, p = 0.005); and fusiform morphology (OR 2.89, 95% CI 1.06-7.85, p = 0.038) to be independently associated with higher rates of incomplete occlusion at last follow-up. Thromboembolic complications were noted in 1.4% and hemorrhagic complications were found in 0.7% of procedures.CONCLUSIONSIncomplete aneurysm occlusion following placement of a PED was independently associated with age > 70 years, aneurysm diameter ≥ 15 mm, and fusiform morphology. Such predictive factors can be used to guide individualized treatment selection and counseling in patients undergoing cerebrovascular neurosurgery.
Reply: Neural detection of complex sound sequences or of statistical regularities in the absence of consciousness?

1 Laboratoire de Recherche en Neuroimagerie (LREN), Department of Clinical Neuroscience, Lausanne University and University Hospital, Lausanne, CH-1011, Switzerland 2 Department of Psychiatry, Psychotherapy, and Psychosomatics, University of Zurich, CH-8032, Switzerland 3 Department of Clinical Neurosciences, University Hospital, Lausanne, CH-1011, Switzerland 4 Adult Intensive Care Medicine, CH-1011, Lausanne University Hospital, Switzerland
Expression of Conventional and Unconventional Actins in Chlamydomonas reinhardtii upon Deflagellation and Sexual Adhesion

ABSTRACT Chlamydomonas has two actin genes, one coding for a conventional actin and the other coding for a highly divergent actin. The divergent actin NAP (for “novel actin-like protein”) is expressed only negligibly in wild-type cells but abundantly in a null mutant of conventional actin, the ida5 mutant. The presence of the dormant NAP gene suggests that NAP may also have its own function in wild-type cells under some conditions. However, no specific functions have been suggested. In this study, we examined the expression of actin and NAP in wild-type and ida5 cells under conditions where actin function has been shown to be important. We found that deflagellation induces the expression of NAP as well as that of actin in wild-type cells. The expressed NAP becomes localized to the regrown flagella, apparently without being associated with dynein. Mating of gametes also increased the expression of actin in wild-type cells and that of NAP in ida5 cells, resulting in accumulation of these proteins in flagella (in both wild-type and ida5 cells) and the fertilization tubule (only in wild-type cells). However, it did not induce significant NAP expression in wild-type cells. These and other observations suggest that the expression of actin and NAP mRNAs is controlled by two discrete mechanisms and that NAP plays a role in flagellar formation in wild-type cells.
Collaborative learning in networks

Complex problems in science, business, and engineering typically require some tradeoff between exploitation of known solutions and exploration for novel ones, where, in many cases, information about known solutions can also disseminate among individual problem solvers through formal or informal networks. Prior research on complex problem solving by collectives has found the counterintuitive result that inefficient networks, meaning networks that disseminate information relatively slowly, can perform better than efficient networks for problems that require extended exploration. In this paper, we report on a series of 256 Web-based experiments in which groups of 16 individuals collectively solved a complex problem and shared information through different communication networks. As expected, we found that collective exploration improved average success over independent exploration because good solutions could diffuse through the network. In contrast to prior work, however, we found that efficient networks outperformed inefficient networks, even in a problem space with qualitative properties thought to favor inefficient networks. We explain this result in terms of individual-level explore-exploit decisions, which we find were influenced by the network structure as well as by strategic considerations and the relative payoff between maxima. We conclude by discussing implications for real-world problem solving and possible extensions.
The British Infantile and Childhood Glaucoma (BIG) Eye Study.

PURPOSE Pediatric glaucoma is a rare, potentially blinding condition, yet, in the United Kingdom, there is a paucity of contemporary epidemiologic and clinical data regarding this condition. The British Infantile and Childhood Glaucoma (BIG) Eye Study is the first national population-based study conducted to examine the incidence, detection patterns, current management, and intraocular pressure (IOP) control at 1 year in children with newly diagnosed glaucoma in the United Kingdom. METHODS A prospective study was conducted wherein children in the United Kingdom and Republic of Ireland aged <or=16 years with newly diagnosed primary or secondary glaucoma, were identified by consultant ophthalmologists through active surveillance from December 2001 until November 2002. Eligible cases were re-evaluated 12 months after notification. RESULTS Of the 99 eligible children with newly diagnosed glaucoma, 47 had primary and 52 secondary glaucoma. The annual incidence of diagnosis of primary congenital glaucoma (PCG) in Great Britain was 5.41 in 100,000 (1/18,500) live births and in the Republic of Ireland, 3.31 in 100,000 (1/30,200). The incidence of PCG in children of Pakistani origin was almost nine times that of Caucasians. IOP control of <or=21 mm Hg was achieved in 94% with medications (60% without medications) in cases of PCG and in 86% with medications (28% without medications) in cases of secondary glaucoma. CONCLUSIONS The British annual incidence of PCG diagnosis is comparable to that reported for other similar populations. Ethnic minorities from South Asia are at significantly increased risk of PCG. Successful IOP control in PCG after surgery in Britain is comparable to that in the published literature.
Medusiform fossil of Kaili fauna from Taijiang, Guizhou

The medusiform fossils described here were discovered by Zhao Yuan-long et al. in 1982 from the middle part of the Kaili Formation(early Middle Cambrian)of Taijiang, eastern Guizhou, SW China. Since then, more than 100 specimens have been collected, consisting of Rotadiscus guizhouensis sp. nov., a new species of the Lower Cambrian genus Rotadiscus from Chengjiang, eastern Yunnan, and an undeterminable species. The specimens from Taijiang are preserved as moulds and casts of medusiform body, which were compressed into very thin discs and completely flattened into films in mudstone and silty mudstone. Up to now 5-horizons of medusiform fossils have been discovered in the middle part of the Kaili Formation. Tentacles protruding from the mouth can be traced on a few specimens. which is quite similar to Rotadiscus grandis from Lower Cambrian of Yunnan, despite of little difference in preservation. The fossils of R.guizhouensis sp. nov. from Taijiang are associated with abundant trilobites, such as Oryctocephalus, Pagetia, Peronopsis, Kaotaia, Olennoides, and echinoderms, brachipods, hyolithid, large bivalved arthropods etc. It is very interesting to note that there are many large.
Estimation of the number of mutations necessary to cause chronic myeloid leukaemia from epidemiological data

The exponential increase in incidence of most malignancies with age can be explained by the requirement for a number of independent somatic mutations. A simple mathematical model can be applied to chronic myeloid leukaemia, which predicts three stem cell mutations necessary for the disease; progression to blast crisis is caused by only one more stem cell mutation or mutations restricted to committed cells.
Leptin corrects host defense defects after acute starvation in murine pneumococcal pneumonia.

RATIONALE Leptin is an adipocyte-derived hormone that declines dramatically during fasting and plays a pivotal role in the neuroendocrine response to starvation. Previously, we employed leptin-deficient (ob/ob) mice to identify an important role for leptin in the host defense against Klebsiella pneumonia. OBJECTIVES To assess the effects of fasting on the innate immune response against pneumococcal pneumonia and to determine the effects of maintaining circulating leptin levels on host defense in fasted mice. METHODS C57BL/6 mice were either fed ad libitum or fasted for 48 h and given an intraperitoneal injection of saline or recombinant leptin (1 microg/g of body weight) twice daily for 48 h before bacterial challenge. Mice were challenged with 10(5) cfu of Streptococcus pneumoniae via the intranasal route. MEASUREMENTS AND MAIN RESULTS Lung homogenate S. pneumoniae burden was nearly 20-fold greater in the fasted as compared with fed mice. The impairment in bacterial clearance observed in fasted animals was associated with reduced bronchoalveolar lavage neutrophil counts and interleukin-6 and macrophage inflammatory protein-2 levels. Alveolar macrophages from fasted animals also exhibited defective phagocytosis and killing of S. pneumoniae and reduced calcium-ionophore-stimulated leukotriene B(4) synthesis in vitro. In contrast, the provision of exogenous leptin to fasted animals restored bacterial clearance, bronchoalveolar lavage levels of neutrophils and cytokines, alveolar macrophage bacterial killing, and leukotriene B(4) synthesis. CONCLUSIONS These results suggest that reduced leptin levels substantially contribute to the suppression of pulmonary antibacterial host defense during starvation and that administration of this adipokine may be of therapeutic benefit clinically.
Quadrilateral H(div) Finite Elements

We consider the approximation properties of quadrilateral finite element spaces of vector fields defined by the Piola transform, extending results previously obtained for scalar approximation. The finite element spaces are constructed starting with a given finite dimensional space of vector fields on a square reference element, which is then transformed to a space of vector fields on each convex quadrilateral element via the Piola transform associated to a bilinear isomorphism of the square onto the element. For affine isomorphisms, a necessary and sufficient condition for approximation of order r + 1 in L2 is that each component of the given space of functions on the reference element contain all polynomial functions of total degree at most r. In the case of bilinear isomorphisms, the situation is more complicated and we give a precise characterization of what is needed for optimal order L2-approximation of the function and of its divergence. As applications, we demonstrate degradation of the convergence order on quadrilateral meshes as compared to rectangular meshes for some standard finite element approximations of H(div). We also derive new estimates for approximation by quadrilateral Raviart--Thomas elements (requiring less regularity) and propose a new quadrilateral finite element space which provides optimal order approximation in H(div). Finally, we demonstrate the theory with numerical computations of mixed and least squares finite element approximations of the solution of Poisson's equation.