Miracle-dz/UniFAR-FTUs huggingface dataset:
Secreted frizzled-related protein 2 is epigenetically silenced and functions as a tumor suppressor in oral squamous cell carcinoma

The role of epigenetic inactivation of secreted frizzled-related protein 2 (SFRP2) and its functions in the development of oral squamous cell carcinoma (OSCC) remain to be elucidated. The present study demonstrated that SFRP2 mRNA was detected in 97.96% of tumor-adjacent normal tissues, while its expression was only detected in 16.33% of the tumor samples. In addition, the loss of SFRP2 expression was associated with hypermethylation of its promoter. As expected, the overexpression of SFRP2 in OSCC cell lines (Tca8113) suppressed cell proliferation and arrested the cell cycle in the G1 phase. Overexpression of SFRP2 also effectively repressed tumor growth in xenograft animals. Mechanistic investigations revealed that SFRP2 inhibited the development of OSCC in vitro and in vivo through an increase in the expression levels of glycogen synthase kinase-3β and a decrease in the expression level of cyclin D1, a direct read-out gene of active Wnt signaling. In addition, an increase in the expression of β-catenin was observed in the Tca8113/SFRP2 cells and in the animal models overexpressing SFRP2. Therefore, the results of the present study provide insight into the role of SFRP2 as a functional tumor suppressor in the development of OSCC through inhibition of the Wnt signaling pathway. Further studies on the precise mechanisms underlying the inhibition of Wnt signaling by SFRP2 and its association with β-catenin are required.
A Comparison of the Degree of Student Satisfaction using a Simulation or a Traditional Wet Lab to Teach Physical Properties of Ice

It is often difficult to offer food chemistry students traditional, hands-on laboratory experiences due to lack of funds for equipment, insufficient laboratory space, or the nature of distance education. A traditional wet laboratory exercise was developed to demonstrate the effects of the physical properties of ice formation when making high-quality sorbets, varying the amounts of sugar, water, and stabilizer. This wet lab was compared to a simulated, detective-based crime scene investigation (CSI) of why a famous food scientist's sorbet had become a “stiff. ” Forty-six food chemistry students were randomly assigned to groups, completing either the traditional wet lab or the simulated lab 1st before completing the 2nd type of laboratory. While there were preferences for one lab over another, there were no differences in the learning outcomes between the 2 laboratory formats. Students who preferred the simulated lab felt they could move at their own pace and were able to stop and review the simulation to understand the concepts more clearly. Traditional wet lab proponents liked working in groups and having immediate access to instructors. From the initial evaluation it appears that simulations could be used as replacements for hands-on laboratory experiences or could serve as effective introductions to laboratory principles and concepts, resulting in increased student learning.
Geographic Association of Rickettsia felis-Infected Opossums with Human Murine Typhus, Texas

Application of molecular diagnostic technology in the past 10 years has resulted in the discovery of several new species of pathogenic rickettsiae, including Rickettsia felis. As more sequence information for rickettsial genes has become available, the data have been used to reclassify rickettsial species and to develop new diagnostic tools for analysis of mixed rickettsial pathogens. R. felis has been associated with opossums and their fleas in Texas and California. Because R. felis can cause human illness, we investigated the distribution dynamics in the murine typhus–endemic areas of these two states. The geographic distribution of R. felis-infected opossum populations in two well-established endemic foci overlaps with that of the reported human cases of murine typhus. Descriptive epidemiologic analysis of 1998 human cases in Corpus Christi, Texas, identified disease patterns consistent with studies done in the 1980s. A close geographic association of seropositive opossums (22% R. felis; 8% R. typhi) with human murine typhus cases was also observed.
Dimerization of ABCG2 Analysed by Bimolecular Fluorescence Complementation

ABCG2 is one of three human ATP binding cassette transporters that are functionally capable of exporting a diverse range of substrates from cells. The physiological consequence of ABCG2 multidrug transport activity in leukaemia, and some solid tumours is the acquisition of cancer multidrug resistance. ABCG2 has a primary structure that infers that a minimal functional transporting unit would be a homodimer. Here we investigated the ability of a bimolecular fluorescence complementation approach to examine ABCG2 dimers, and to probe the role of individual amino acid substitutions in dimer formation. ABCG2 was tagged with fragments of venus fluorescent protein (vYFP), and this tagging did not perturb trafficking or function. Co-expression of two proteins bearing N-terminal and C-terminal fragments of YFP resulted in their association and detection of dimerization by fluorescence microscopy and flow cytometry. Point mutations in ABCG2 which may affect dimer formation were examined for alterations in the magnitude of fluorescence complementation signal. Bimolecular fluorescence complementation (BiFC) demonstrated specific ABCG2 dimer formation, but no changes in dimer formation, resulting from single amino acid substitutions, were detected by BiFC analysis.
Extractive vs. NLG-based Abstractive Summarization of Evaluative Text: The Effect of Corpus Controversiality

Extractive summarization is the strategy of concatenating extracts taken from a corpus into a summary, while abstractive summarization involves paraphrasing the corpus using novel sentences. We define a novel measure of corpus controversiality of opinions contained in evaluative text, and report the results of a user study comparing extractive and NLG-based abstractive summarization at different levels of controversiality. While the abstractive summarizer performs better overall, the results suggest that the margin by which abstraction outperforms extraction is greater when controversiality is high, providing a context in which the need for generation-based methods is especially great.
Somewhere between Distrust and Dependence: Young People, the Police and Anti-Social Behaviour Management within Marginalised Communities.

Recent concerns in the UK about youth disaffection, anti-social behaviour and gang culture have led to an increase in pre-emptive intervention strategies focused on the policing of groups of young people. This article explores the literature on youth/police relationships and the evidence that suggests that preventive police strategies may have weakened these relationships and may also have had a negative impact on youth engagement in the law enforcement process. The article reports on the outcomes of a small-scale qualitative study conducted in two socially deprived communities in Glasgow (Scotland's largest city). The researchers gathered interview data from young people, police officers, youth workers and local community residents as a means of exploring the current relationship between young people and the police and the way in which local people view this relationship. The findings illustrate the existence of a localised cyclical relationship of mistrust alongside more ambivalent views by the local residents, youth and police. While resentful of police practices in general, young people and residents welcomed the prospect of a procedurally just police force to protect them; police officers valued the opportunity to uphold community safety, but still projected some cynical and stereotypical views. The article concludes with suggested implications for policy, practice and research.
Married to the Job : Wives' Incorporation in Men's Work

Acknowledgements. 1. Introduction Part 1: Hedging Her In: How Men's Work Structures Their Wives' Lives Introduction to Part 1. 2. Time Elements: Patterns, Structures and Competition 3. Work Characteristics: Implications Inside and Outside the Home 4. Spatial Elements: Aspects of the Location of Home and Work 5. Constraints, Identities and Room for Manoeuvre Part 2: Drawing Her In: Wives' Contributions to their Husband's Work Introduction to Part 2. 6. Domestic Labour and the Production of the Male Worker 7. Giving Moral Support 8. Two for the Price of One: Peripheral Activities 9. Two for the Price of One: Back-Up Services 10. Two for the Price of One: the Additional Worker 11. The Productive Work of Wives Part 3: Married to the Job: the Foundations of Wives' Incorporation Introduction to Part 3. 12. Varieties of Incorporation and the Occupational Dimension 13. Doing Three Jobs: the Hierarchy of Priorities 14. Making Sense of Being Married to the Job: Wives' Careers and Projects. Bibliography. Index.
Noninvasive Localization of Accessory Pathways in Patients with Wolff-Parkinson-White Syndrome: A Strain Imaging Study

Background: Noninvasive techniques for the localization of the accessory pathways (APs) might help guide mapping procedures and ablation techniques. We sought to examine the diagnostic accuracy of strain imaging for the localization of the APs in Wolff-Parkinson-White syndrome. Methods: We prospectively studied 25 patients (mean age = 32 ± 17 years, 58.3% men) with evidence of pre-excitation on electrocardiography (ECG). Electromechanical interval was defined as the time difference between the onset of delta wave and the onset of regional myocardial contraction. Time differences between the onset of delta wave (δ) and the onset of regional myocardial contraction (δ-So), peak systolic motion (δ-Sm), regional strain (δ-ε), peak strain (δ-εp), and peak strain rate (δ-SRp) were measured. Results: There was a significant difference between time to onset of delta wave to onset of peak systolic motion (mean ± SD) in the AP location (A) and normal segments (B) versus that in the normal volunteers (C) [A: (57.08 ± 23.88 msec) vs. B: (75.20 ± 14.75) vs. C: (72.9 0 ± 11.16); p value (A vs. B) = 0.004 and p value (A vs. C) = 0.18] and [A: (49.17 ± 35.79) vs. B: (67.60 ± 14.51) vs. C: (67.40 ± 6.06 msec); p value (A vs. B) < 0.001 and p value (A vs. C) = 0.12, respectively]. Conclusion: Our study showed that strain imaging parameters [(δ-So) and (δ-Strain)] are superior to the ECG in the localization of the APs (84% vs. 76%).
Quantifying gene expression: the importance of being subtle

Gene expression is regulated at both the mRNA and protein level through on‐off switches and fine‐tuned control. In their recent study, Edfors et al (2016) use highly accurate, targeted proteomics methods and examine to what extent the amount of protein produced per mRNA transcript varies across different tissues. They find that the bulk part of protein concentrations is set at a per‐gene level: This relationship, the protein/mRNA ratio, is constant across cell types and tissues, but varies by several orders of magnitude across genes.
Isolated systolic hypertension in an elderly Danish population. Prevalence and daytime ambulatory blood pressure

Isolated systolic hypertension (ISH) is a major risk factor for cardiovascular complications. Nevertheless, data on the prevalence in a representative population do not seem to be available. The prevalence of ISH and the white coat effect was thus studied in a cross‐sectional survey of 2806 inhabitants aged 70–80 years. In untreated subjects, the prevalence of ISH was 17.4% (95% CI 14.9–20.2) in women and 13.5% (95% CI 11.3–15.9) in men using clinic blood pressure at first visit. The prevalence increased significantly with age. The prevalence was reduced to 10.4% when using the average of all‐visits clinic blood pressures. By a simulation model, it was demonstrated that his reduction mainly resulted from a regression towards the mean. Average all‐visits clinic blood pressure was 172.6 ±10.4/81.1±6.0 mmHg. Less than one‐third of those with all‐visit ISH had sustained ISH. Identifying subjects with sustained ISH requires measurements in more than three visits.
Facial Emotion Recognition and Discrimination Deficit in Idiopatic Parkinson Patients Introduction Idiopathic Parkinson Disease

Ad dress for Cor res pon den ce/Ya z›fl ma Ad re si: Dr. Ersin Kasım Ulusoy, Develi Hatice Muammer Kocatürk State Hospital, Clinic of Neurology, Kayseri, Turkey Phone: +90 506 668 93 92 E-mail: ersinkasim_ulusoy@hotmail.com Re cei ved/Ge lifl Ta ri hi: 08.10. 2014 Ac cep ted/Ka bul Ta ri hi: 26.01. 2015 Objective: Motor symptoms are the primary focus in diagnosis and treatment of idiopathic Parkinson disease (IPD). But facial emotion recognition disorder, one of non-motor symptoms of the disease, reduces quality of life significantly by disrupting social interaction. Facial emotion recognition and discrimination ability is an important part of social interaction. Neuroimaging studies highlight amigdala as the locus of facial emotion recognition disorder in IPD. The aim of this study is to investigate the relationship between clinical features and impairments in facial emotion recognition and discrimination ability. Materials and Methods: This study involves 41 patients followed with IPD in neurology outpatient clinic and 38 healthy controls. Facial Emotion Identification Test (FEIT) and Facial Emotion Discrimination Test (FEDT) were carried out for both groups. Clinical and demographic features of patient and control groups were recorded. Hoehn-Yahr (H and Y) scale was used for staging of disease and Unified Parkinson’s Disease Rating Scale (UPDRS) was used for assessment of clinical severity. The results of both groups were compared with Kruskal Wallis and Pearson’s Chi Square tests. Results: Average of FEIT and FEDT in patients with IPD are 12.64±5.55 and 17.84±4.94, respectively. When these values were compared with control group, they were worse than control group (p<0.01). This impairment was correlated with H and Y and UPDRS stages. The most impaired one among facial exogenous sensations was fear sensation with 2.29±1.26. Conclusion: This study shows that patients with IPD have more difficulty than normal population in recognition and discrimination of facial exogenous emotions. This difficulty was correlated with stage and clinical severity of disease. We hope that these findings will be an important step in regulation of impaired social intercourse and functionality in IPD and will help determining rehabilitation targets. (Turkish Journal of Neurology 2015; 21:16-21)
Not All Selfies Took Alike: Distinct Selfie Motivations Are Related to Different Personality Characteristics

Selfies have become a frequent and commonplace occurrence, though the reasons which lead people to take selfies remain unclear. This research explores what motivates selfie taking, and suggests that this is not a uniform phenomenon and varying motivations may be found among selfie takers. In addition, the connection between these distinct selfie motivations and personality characteristics, including the big five, narcissism, and self-esteem, as well as types of selfie behaviors are examined. At the first stage of the research, 117 participants filled out a questionnaire dealing with their reasons for taking selfies. An explanatory factor analysis revealed three distinct selfie motivations: self-approval, belonging, and documentation. At the second stage, 191 different participants answered both the same questionnaire, and personality traits questionnaires. A confirmatory factor analysis verified that the three selfie motivations model has a good fit. Our results suggested that each selfie motivator is differently related to personality characteristics: self-approval was negatively related to: conscientiousness, emotional stability, openness to experiences, and self-esteem, and positively correlated to frequent checking for “likes. ” Belonging was related to openness to experiences. Documentation was related to agreeableness and extroversion. Unlike previous studies, none of the selfie motivating factors was found to relate to narcissism. The reasons for these differences, as well as the need to refer to selfie taking as a multidimensional phenomenon, are discussed.
Exploring the “Situation” of Situational Willingness to Communicate: A Volunteer Youth Exchange Perspective

This paper presents the perspectives of youth participating in the Society for Educational Visits and Exchanges in Canada's Volunteer Youth Experience (VYE) as gathered by way of pre- and post-program questionnaires, observations, interviews, and journals. The pan-Canadian questionnaire results suggest that this short, bilingual volunteer experience enhances participant motivation to learn a second official language and to be part of the target community. Triangulated findings from observations, interviews and journals indicate that participants' willingness to communicate (WTC) in the second language (MacIntyre, Dornyei, Clement, & Noels, 1998) may have been influenced by situational factors inherent to the volunteer experience such as access to native speakers of the target language and opportunities for authentic community participation.
Identity Negotiating: Redefining Stigmatized Identities through Adaptive Sports and Recreation Participation among Individuals with a Disability

Abstract The purpose of this study was to investigate the meanings and outcomes of adaptive sport and recreation participation among individuals with disabilities. In-depth open-ended interviews were conducted with 17 individuals. Analysis of the data followed qualitative data analysis and classical grounded theory utilizing line by line coding, identification of emergent themes, and identification of a core category grounded in the data. Results indicated that participants felt stigmatized and stereotyped, but their adaptive sports and recreation participation provided them with opportunities to build social networks, experience freedom and success, positively compare themselves with others without disabilities, and feel a sense of normalcy. The core variable identified adaptive sports and recreation participation as an opportunity structure that facilitated the identity negotiating process.
Transactors, Transformers and Beyond. A Multi-Method Development of a Theoretical Typology of Leadership.

Extends the transactional‐transformational model of leadership by deductively developing four theoretical behavioral types of leadership based on a historical analysis of leadership literature. Then, in an exploratory empirical phase, uses two data sets to inductively develop alternative models of leadership types. Finally, with a third data set, tests several theoretically plausible typologies using second‐order confirmatory factor analysis (CFA). The results of the CFA generally support the existence of four leadership types: directive leadership, transactional leadership, transformational leadership, and empowering leadership.
Optimal sizing of hybrid power system using genetic algorithm

This paper presents an optimized design of stand-alone multi sources hybrid power system includes sources like, wind farm, photovoltaic array, diesel generator and battery bank based on an evolutionary algorithm. In this work, the battery bank has been used to cover the emergency loads energy. For this approach, economic aspects such as interest rate, inflation, capital recovery factor, sinking found factor have been expressed for each power sources, and then an objective function with aim to minimizing of all system costs, has been clarified. A genetic algorithm approach is employed to obtain the best cost value of hybrid power system construction. Simulation results show this method calculates the electrification costs (capital cost, replacement costs, operation and maintenance cost and fuel cost) over a period of 20 years for two different cases
Multiscale Representations for Fast Pattern Matching in Stream Time Series

Similarity-based time-series retrieval has been a subject of long-term study due to its wide usage in many applications, such as financial data analysis, weather data forecasting, and multimedia data retrieval. Its original task was to find those time series similar to a pattern (query) time-series data, where both the pattern and data time series are static. Recently, with an increasing demand on stream data management, similarity-based stream time-series retrieval has raised new research issues due to its unique requirements during the stream processing, such as one-pass search and fast response. In this paper, we address the problem of matching both static and dynamic patterns over stream time-series data. We will develop a novel multiscale representation, called multiscale segment mean, for stream time-series data, which can be incrementally computed and thus perfectly adapted to the stream characteristics. Most importantly, we propose a novel multistep filtering mechanism, step by step, over the multiscale representation. Analysis indicates that the mechanism can greatly prune the search space and thus offer fast response. Furthermore, batch processing optimization and the dynamic case where patterns are also from stream time series are discussed. Extensive experiments show the multiscale representation together with the multistep filtering scheme can efficiently filter out false candidates and detect patterns, compared to the multiscale wavelet.
Compensation for Work‐Related Injuries and Rehabilitation of Patients With Chronic Pain

A group of 61 patients with problems of chronic pain were managed through a rehabilitation program based on the principles of operant conditioning. Of these patients, 35 were receiving compensation for work-related accidents, and 26 were receiving no financial compensation for their chronic pain. Of the patients not receiving compensation, 69% (18) made significant increases in their functional performances, while only 43% (15) of the compensation group made similar increases.
International Journal of Hospitality Management Exploring the Antecedents of Effectiveness and Efficiency

Our knowledge of determinants of effectiveness and efficiency of firms continues to expand. However , this knowledge remains quite fragmented and non-cumulative in the service industry. Herein, this study explores the effect of entrepreneurial and financial orientations as two key contributors to performance in the service industry. Data for this study were collected from 182 hotels in Switzerland to examine the effect of a financial strategic orientation and an entrepreneurial strategic orientation on two widely-used standards of business performance—effectiveness and efficiency. We hypothesized that these effects would be more pronounced under certain dynamic environment conditions. Findings provide new insights about the merits of building bridges between the entrepreneurial orientation and financial orientation. Within the context of existing research on strategic management, we discuss the implications of our findings for hotel managers and address the study's limitations and future research directions.
Analysis and simulation of speed control of PMBLDC motor by PI controller

This paper deals with analysis and design of a speed controller for PMBLDC motor. The brushless DC motor has permanent-magnets on rotor and the stator windings are wound such that the back electromotive force is trapezoidal in nature. The control unit used is a PI controller, which governs the duty cycle of the PWM pulses applied to the switches of the inverter to run the motor at desired speed. The simulation of the proposed scheme was done using MATLAB software package in SIMULINK environment.