Miracle-dz/UniFAR-FTUs huggingface dataset:
Activation of Endocytosis as an Adaptation to the Mammalian Host by Trypanosomes

ABSTRACT Immune evasion in African trypanosomes is principally mediated by antigenic variation, but rapid internalization of surface-bound immune factors may contribute to survival. Endocytosis is upregulated approximately 10-fold in bloodstream compared to procyclic forms, and surface coat remodeling accompanies transition between these life stages. Here we examined expression of endocytosis markers in tsetse fly stages in vivo and monitored modulation during transition from bloodstream to procyclic forms in vitro. Among bloodstream stages nonproliferative stumpy forms have endocytic activity similar to that seen with rapidly dividing slender forms, while differentiation of stumpy forms to procyclic forms is accompanied by rapid down-regulation of Rab11 and clathrin, suggesting that modulation of endocytic and recycling systems accompanies this differentiation event. Significantly, rapid down-regulation of endocytic markers occurs upon entering the insect midgut and expression of Rab11 and clathrin remains low throughout subsequent development, which suggests that high endocytic activity is not required for remodeling the parasite surface or for survival within the fly. However, salivary gland metacyclic forms dramatically increase expression of clathrin and Rab11, indicating that emergence of mammalian infective forms is coupled to reacquisition of a high-activity endocytic-recycling system. These data suggest that high-level endocytosis in Trypanosoma brucei is an adaptation required for viability in the mammalian host.
Visual saliency guided mode decision in video compression based on Laplace distribution of DCT coefficients

A visual saliency based approach for macroblock (MB) mode selection in video compression is presented. It is based on the Laplace distribution of transformed residuals. Visual saliency of a MB is used to make the encoder vote for a mode which requires less bits in a region which is visually less important. It shows a gain of up to 0.6 dB in terms of PSNR compared to conventional rate-distortion optimization (RDO) procedure in H.264/AVC. Moreover, it suggests to be a competitive alternative to a well-established perceptually based video coding method. At the same time it has no negative impact on the PSNR.
Reversal strategy in antagonizing the P2Y12‐inhibitor ticagrelor

Patients on antiplatelet therapy have a higher incidence of bleeding complications. Reversal of antiplatelet drug effects is an important issue at trauma or emergency departments. For old and conventional anticoagulants, reversal strategies are established. While the effects of ticagrelor are reversible, developing a method to restore platelet function in patients is of importance due to its longer half‐life (approximately 8 h), compared with other P2Y12‐inhibitors.
Transient Phase-locking and Dynamic Correlations: Are They the Same Thing?

This work represents an attempt to bring together two important themes in neuronal dynamics. The first is the characterization of dynamic correlations in multiunit recordings of spike activity using joint-peri-stimulus time histograms (J-PSTHs) [Aertsen and Preissl, 1991: Non Linear Dynamics and Neural Networks]. The second is transient phase-locking at high (gamma) frequencies, either in terms of spiking in separable spike trains [e. In this paper we suggest that transient phase-locking is necessary for frequency-specific, dynamic event-related correlations. This point is demonstrated using the gamma-frequency (36 Hz) component of neuromagnetic signals measured in the prefrontal and partial regions of a subject during self-paced movements. A J-PSTH analysis revealed dynamic changes in prefronto-parietal correlations in relation to movement onset. These frequency-specific dynamic correlations were associated with changes in the degree of phase-locking, of the sort reported by Desmedt and
First-principles calculations of atomic and electronic structure of SrTiO 3 (001) and (011) surfaces

We present the results of calculations of surface relaxations, energetics, and bonding properties for CaTiO3 (001) and (011) surfaces using a hybrid B3PW description of exchange and correlation. We consider both CaO and TiO2 terminations of the non-polar (001) surface, and Ca, TiO and O terminations of the polar (011) surface. On the (001) surfaces, we find that all upper-layer atoms relax inwards on the CaO-terminated surface, while outward relaxations of all atoms in the second layer are found for both terminations. For the TiO2-terminated (001) surface, the largest relaxations are on the second-layer atoms. The surface rumpling is much larger for the CaO-terminated than for the TiO2-terminated (001) surface, but their surface energies are quite similar at 0.94eV and 1.13eV respectively. In contrast, different terminations of the (011) CaTiO3 surface lead to very different surface energies of 1.86eV, 1.91eV, and 3.13eV for the O-terminated, Ca-terminated, and TiO-terminated (011) surface respectively. Our results for surface energies contrast sharply with those of Zhang et al. [Phys. Rev. B 76, 115426 (2007)], where the authors found a rather different pattern of surface energies. We predict a considerable increase of the Ti-O chemical bond covalency near the (011) surface as compared both to the bulk and to the (001) surface.
The association between point-of-sale displays and youth smoking susceptibility.

INTRODUCTION According to tobacco industry documents, tobacco displays within the retail environment assume a much greater importance with the loss of other marketing channels. The impact of these displays upon young people and their future intentions to smoke (susceptibility) is, therefore, of significant interest to public health. METHODS A cross-sectional in-home survey was conducted in 2008 with young people (N = 1,401) aged 11-16 years, recruited from across the United Kingdom. We examine the salience of and attraction to cigarette displays at point-of-sale (POS), among youth, and whether this is associated with susceptibility. We concentrate exclusively on the 956 never-smokers. RESULTS Logistic regression, controlling for known risk factors of youth smoking, found that noticing cigarette displays was associated with higher levels of susceptibility (odds ratio [OR] = 1.77, p < .05) and greater attraction to displays was associated with higher susceptibility (OR = 1.07, p < .001). CONCLUSIONS It is difficult, if not impossible, to safeguard young people from exposure to displays of tobacco at POS. That these displays were associated with increased susceptibility suggests that moves to place tobacco out of sight in the United Kingdom, and elsewhere, are justified.
A Direct-Sum Theorem for Read-Once Branching Programs

We study a direct-sum question for read-once branching programs. If M(f) denotes the minimum average memory required to compute a function f(x_1,x_2, ., x_n) how much memory is required to compute f on k independent inputs that arrive in parallel? We show that when the inputs are sampled independently from some domain X and M(f) = Omega(n), then computing the value of f on k streams requires average memory at least Omega(k * M(f)/n). Our results are obtained by defining new ways to measure the information complexity of read-once branching programs. We define two such measures: the transitional and cumulative information content. We prove that any read-once branching program with transitional information content I can be simulated using average memory O(n(I+1)). On the other hand, if every read-once branching program with cumulative information content I can be simulated with average memory O(I+1), then computing f on k inputs requires average memory at least Omega(k * (M(f)-1)).
Learning New Grammatical Structures in Task‐Based Language Learning: The Effects of Recasts and Prompts

In the present study, we examine the effects of prompts and recasts on the acquisition of two new and different grammar structures in a task-based learning environment. Sixty-four 14-year-old 9th grade students (low intermediate) learning German as a foreign language were randomly assigned to three conditions: two experimental groups (one receiving prompts, the other recasts) and a control group. The study involves two subsequent interventions: The first targeted a complex structure, dative case after a preposition; the second a simple structure, comparatives. Pretests, immediate posttests, and delayed posttests included written and oral accuracy as well as oral fluency. Statistical comparisons on both written and oral posttests showed that prompts and recasts were effective, when compared to the control group, with prompts being superior to recasts. Furthermore, the effect of recasts depended on the structure: Recasts were more effective for the comparative than for the dative on written accuracy.
Instruction Set Usage Analysis for Application-Spe cific Systems Design

The manner in which the resources of a microprocess or are used affects its performance, power consumption and size. In this work we show how inc reasing the size of a processor's instruction set, in turn, increases the amount of hardware needed to impleme nt that processor. We also study how efficiently th e hardware resources of four processor architectures are used by measuring the static instruction set u tilization of a group of benchmark applications. The architect ures examined are the Intel x86, Intel x86-64, MIP S64, and PowerPC. We introduce the notions of instruction sexact cores and general-purpose cores, and then we use these concepts to propose a new measure of pro cessor resource utilization, core density. Based on the core density measure we show that on average 9 exact cor es are equivalent to a single general-purpose core in the existing architectures and that in particular insta nces this multiplier can go up to 48 exact cores.
Estudo comparativo entre o aproveitamento escolar de alunos de escola de 1º grau e teste de inibição de emissões otoacústicas transientes

School learning can be hampered if there are defects on the central auditory process. Since those with auditory deficiency can be rehabilitated, it is fundamental that we identify them. Otoacoustic emissions test has low cost and operational ease. Study design: clinical and experimental. AIM: to study the relationship between school learning and transient otoacoustic emission suppression by contralateral stimuli. MATERIAL AND METHODS: 39 individuals, from 7 to 12 years of age were evaluated, 19 (48.7%) with good school performance and 20 (51.3%) poor performers. RESULTS: A transient otoacoustic emission suppression failure for contralateral acoustic stimuli was more frequently found among children with poor school performance. We established a value of 1.6 dB SPL for emission reduction that characterized those children as belonging to the poor learning performance group: sensitivity 65%, specificity 72,2%, accuracy of 68.4%, positive predictive value of 72.2%. CONCLUSION: The contralateral emission suppression test of the right ear can be predictive of school difficulties in individuals from six to twelve years of age.
Triacylglyceride, Antioxidant and Antimicrobial Features of Virgin Camellia oleifera, C. reticulata and C. sasanqua Oils

Virgin oils obtained from seeds of Camellia oleifera (CO), Camellia reticulata (CR) and Camellia sasanqua (CS) were studied for their triacylglyceride composition, antioxidant and antimicrobial activities. Levels of fatty acids determined by 1H-nuclear magnetic resonance analysis were similar to those reported for olive oils (82.30%–84.47%; 5.69%–7.78%; 0.26%–0.41% and 8.04%–11.2%, for oleic, linoleic, linolenic and saturated acids, respectively). The CR oil showed the best antioxidant potential in the three in vitro models tested. With regard to EC50 values (µg/mL), the order in DPPH radical-scavenging was CR (33.48) < CO (35.20) < CS (54.87). Effectiveness in reducing power was CR (2.81) < CO (3.09) < CS (5.32). IC50 for LPO inhibition were 0.37, 0.52 and 0.75 µg/mL for CR, CO and CS, respectively. All the oils showed antimicrobial activity, and exhibited different selectivity and MICs for each microorganism tested (E. coli, B. cereus and C. albicans). B. cereus was the less sensitive species (MIC: 52.083 ± 18.042 for CO; 41.667 ± 18.042 for CR; 104.167 ± 36.084 for CS mg/mL) and the E. coli was the most sensitive to camellia oil’s effect. The standard gentamicin presented higher MIC for E. coli (4.2) than the CR (MIC= 2.6) and CO (MIC = 3.9) oils.
The Evolution of Gay Travel Research

This paper explores literature relating to the gay travel market. It argues that the current discourse in this area has largely concentrated on the demand–led approaches such as the motivations and demographic profiles of gay travellers and the use of gay space. However, in light of societal change as well as the increasing role of technology, there is a need to revisit the demographic, motivational and behavioural characteristics of gay travellers, particularly in the context of their use of gay space. With this in mind, this paper highlights a number of significant opportunities for future research into the gay travel market.
Student Role Supports for Younger and Older Middle- Aged Women: Application of a Life Event Model

This paper is a report on a study of 276 women aged 35 to 64 who have re- entered university. We used the life-event framework to focus on the stress of university life, on the methods these women use to cope with stress and on their adaptations to the demands of school. We compared the re-entry experience of two sub-groups in our population: students aged 35 to 44 (with young families) and those aged 45 to 64 (with mature families). We found that each group had different motives for attending school, each group felt different strains during the school year and each group used different methods and resources to cope with the demands of student life. The paper concludes with a review of the literature on programs that meet the needs of re-entry women. We note the applicability of these programs to the distinct needs of younger and older re- entry women and we encourage the development of more programs to meet both groups' needs.
Serendipitous active galactic nuclei in the XMM—Newton fields of Markarian 205 and QSO 0130−403

The X-ray spectra of serendipitously observed active galactic nuclei (AGN) in the XMM-Newton fields of Mrk 205 and QSO 0130-403 are analysed. The sample consists of 23 objects, none of which is detected at radio frequencies, with a median X-ray luminosity of ∼4 x 10 4 4 erg s - 1 and redshifts ranging from ∼0.1 to just over 3. The mean photon index was found to be 1.89 ′ 0.04. In contrast with past ASCA and ROSAT observations of high-redshift radio-loud quasars, we find little evidence for excess intrinsic absorption in these radio-quiet objects, with only three sources requiring a column density in excess of the Galactic value. Comparing the measured spectral indices over the redshift range, we also find there is no X-ray spectral evolution of quasi-stellar objects (QSOs) with time, up to redshift of 3. Within the sample there is no evidence for evolution of the optical to X-ray spectral index, α o x , with redshift, the mean value being -1.66 ′ 0.04. However, upon comparing the values from the Bright Quasar Survey at low redshift (z 4), a slight steepening of α o x is noted for the more distant objects. In most of the sources there is no significant requirement for a soft excess, although a weak thermal component (≤10 per cent of L X ) cannot be excluded. There is an indication of spectral flattening (by ΔΓ = 0.2) at higher energies (>3 keV, QSO rest frame) for the sample as a whole. This is consistent with the presence of a Compton reflection component in these radio-quiet AGN, with the scattering medium (such as an accretion disc or molecular torus) occupying a solid angle of 2π sr to the X-ray source.
Avian migrants adjust migration in response to environmental conditions en route

The onset of migration in birds is assumed to be primarily under endogenous control in long-distance migrants. Recently, climate changes appear to have been driving a rapid change in breeding area arrival. However, little is known about the climatic factors affecting migratory birds during the migration cycle, or whether recently reported phenological changes are caused by plastic behavioural responses or evolutionary change. Here, we investigate how environmental conditions in the wintering areas as well as en route towards breeding areas affect timing of migration. Using data from 1984 to 2004 covering the entire migration period every year from observatories located in the Middle East and northern Europe, we show that passage of the Sahara Desert is delayed and correlated with improved conditions in the wintering areas. By contrast, migrants travel more rapidly through Europe, and adjust their breeding area arrival time in response to improved environmental conditions en route. Previous studies have reported opposing results from a different migration route through the Mediterranean region (Italy). We argue that the simplest explanation for different phenological patterns at different latitudes and between migratory routes appears to be phenotypic responses to spatial variability in conditions en route.
Role of Neuroepithelial Sonic hedgehog in Hypothalamic Patterning

The hypothalamus is a region of the diencephalon with particularly complex patterning. Sonic hedgehog (Shh), encoding a protein with key developmental roles, shows a peculiar and dynamic diencephalic expression pattern. Here, we use transgenic strategies and in vitro experiments to test the hypothesis that Shh expressed in the diencephalic neuroepithelium (neural Shh) coordinates tissue growth and patterning in the hypothalamus. Our results show that neural Shh coordinates anteroposterior and dorsoventral patterning in the hypothalamus and in the diencephalon–telencephalon junction. Neural Shh also coordinates mediolateral hypothalamic patterning, since it is necessary for the lateral hypothalamus to attain proper size and is required for the specification of hypocretin/orexin cells. Finally, neural Shh is necessary to maintain expression of differentiation markers including survival factor Foxb1.
HIV surveillance among injecting drug users.

Injecting drug users (IDUs) should be considered a 'partially hidden population' at high risk for HIV infection. In almost all locations it should be possible to locate and conduct research with IDUs, but it will probably never be possible to enumerate or draw random samples from an IDU population. Surveillance research studies with IDUs should include risk behaviors, as surveillance of HIV infection only will not be sufficiently time sensitive, and be used to develop and refine HIV prevention programming for the population. Contacts with IDUs can be developed at multiple settings, including voluntary treatment programs, law enforcement settings, and through 'street outreach. ' Each type of setting has different advantages, disadvantages and ethical concerns. HIV testing as part of surveillance also raises additional important ethical concerns. The primary risk behaviors that should be included in surveillance studies are 'sharing' of drug injection equipment, the potential for rapid partner change among risk partners, and sexual risk behavior. Additional important objectives for surveillance research include: (1) the size of the local IDU population, (2) patterns of drug use, (3) availability injection equipment, (4) participation in prevention activities, and (5) access to and use of anti-retroviral treatments. HIV incidence is an ultimate objective for surveillance research, but there are no currently available cost-efficient methods for studying HIV incidence, so estimation from indirect measurements is usually required.
A survey of blindness and poor vision in leprosy patients.

OBJECTIVE To determine the prevalence, cause and distributions of blindness and poor vision in patients with leprosy. METHODS An epidemiological survey of blindness and poor vision among 1045 cases of leprosy was carried out in Taixing City of Jiangsu Province, China. RESULTS The prevalence of bilateral blindness was 7.67%, unilateral blindness 4.4%, bilateral poor vision of various degrees 9.28% and unilateral poor vision 5.84%. The prevalence of eye complications varied significantly among different groups of patients; females had a higher prevalence than males, multibacillary patients higher than paucibacillary patients, and in-patients higher than out-patients. Corneal disease was the most common cause of blindness in study groups, followed by iritic disease and cataract; while the main cause of poor vision was cataract, then corneal and iritic diseases. Treatable blindness accounted for 62.7% of the cases and treatable poor vision for 88.6% of the patients studied. 56.62% of cases with eye complications expressed their willingness to be treated. CONCLUSIONS Although prevention and treatment of low vision and blindness in leprosy patients is very hard, it is necessary for doctors and medical workers to make clear of the factors to cause low vision and blindness, especially those in leprosy patients so that some measures for prevention and treatment of the disease could be taken accordingly.
The chimerical and multifaceted marine acoel Symsagittifera roscoffensis: from photosymbiosis to brain regeneration

A remarkable example of biological engineering is the capability of some marine animals to take advantage of photosynthesis by hosting symbiotic algae. This capacity, referred to as photosymbiosis, is based on structural and functional complexes that involve two distantly unrelated organisms. These stable photosymbiotic associations between metazoans and photosynthetic protists play fundamental roles in marine ecology as exemplified by reef communities and their vulnerability to global changes threats. Here we introduce a photosymbiotic tidal acoel flatworm, Symsagittifera roscoffensis, and its obligatory green algal photosymbiont, Tetraselmis convolutae (Lack of the algal partner invariably results in acoel lethality emphasizing the mandatory nature of the photosymbiotic algae for the animal's survival). Together they form a composite photosymbiotic unit, which can be reared in controlled conditions that provide easy access to key life-cycle events ranging from early embryogenesis through the induction of photosymbiosis in aposymbiotic juveniles to the emergence of a functional “solar-powered” mature stage. Since it is possible to grow both algae and host under precisely controlled culture conditions, it is now possible to design a range of new experimental protocols that address the mechanisms and evolution of photosymbiosis. S. roscoffensis thus represents an emerging model system with experimental advantages that complement those of other photosymbiotic species, in particular corals. The basal taxonomic position of S. roscoffensis (and acoels in general) also makes it a relevant model for evolutionary studies of development, stem cell biology and regeneration. Finally, it's autotrophic lifestyle and lack of calcification make S. roscoffensis a favorable system to study the role of symbiosis in the response of marine organisms to climate change (e.g., ocean warming and acidification). In this article we summarize the state of knowledge of the biology of S. roscoffensis and its algal partner from studies dating back over a century, and provide an overview of ongoing research efforts that take advantage of this unique system.