Miracle-dz/UniFAR-FTUs huggingface dataset:
Posaconazole: An Update of Its Clinical Use

Posaconazole (PCZ) is a relatively new addition to the azole antifungals. It has fungicidal activities against Aspergillus fumigatus, Blastomyces dermatitidis, selected Candida species, Crytopcoccus neoformans, and Trichosporon. PCZ also has fungistatic activities against Candida, Coccidioides, selected Fusarium spp. , Histoplasma, Scedosporium and Zygomycetes. In addition, combining the drug with caspofungin or amphotericin B results in a synergistic interaction against A. fumigatus, C. glabrata and C. neoformans. The absorption of PCZ suspension is enhanced when given with food, nutritional supplements, and carbonated beverages. Oral administration of PCZ in divided doses also increases its bioavailability. PCZ has a large volume of distribution and is highly protein bound (>95%). The main elimination route of PCZ is fecal. PCZ is an inhibitor of the CYP3A4 enzyme; therefore, monitoring for drug-drug interactions is warranted with other CYP3A4 substrates/inhibitors/inducers. The most common adverse effects include headache, fatigue, nausea, vomiting and elevated hepatic enzymes. PCZ, with its unique antifungal activities, expands the azole class of antifungal agents. Because of its limit in formulation, PCZ oral suspension is recommended in immunocompromised patients with functional gastrointestinaltracts who fail conventional antifungal therapies or who are suspected to have a breakthrough fungal infection. However, a delayed-release tablet formulation and intravenous (IV) injection became available in 2014, expanding the use of PCZ in other patient populations, including individuals who are unable to take oral formulations.
The Rendering of Ideology in the English-Indonesian Translation of Brontё‟s Jane Eyre

This study deals with the rendering of ideology found in the English-Indonesian translation of Brontё‘s Jane Eyre. The main objective of this study is to investigate the rendering ideology in Brontё‘s Jane Eyre from English into Indonesian which is realized in the vocabulary and grammar choices used by the translator in translating ideology in Jane Eyre from English into Indonesian. It used descriptive qualitative approach. Moreover, Critical Discourse Analysis (CDA) proposed by Fairclough (1989) is used as the framework of the study. The data obtained were taken from ‗Jane Eyre‘ by Charlotte Brontё and it is translated by Lulu Wijaya entitled Jane Eyre. The unit of analysis of the study was ideological content including word, phrase, clause, sentence, and paragraph contained in Jane Eyre and its translation.The results showed that there are 120 ideologically loaded-data which is categorized into Ideology. They are ideology as tacit assumptions, beliefs and value systems. Meanwhile, there are 32 (27%) data which are not lexically equivalent in the Indonesian translation. Thus, the remaining data represent the ideology of the source text in the same way. Based on those findings, the writers concluded that most of the ideologically-contested words, nominalizations, and voices are rendered into Indonesian. There are no ideological differences between the source text and its translation. Furthermore, the translators mostly expressed ideology of the source similarly by means of selecting similar lexical choices. It means that translator‘s ideology in the source text and their translation in the target text reach ideological equivalent.
On the Use of Instrumental Variables in Accounting Research

Instrumental variable (IV) methods are commonly used in accounting research (e.g., earnings management, corporate governance, executive compensation, and disclosure research) when the regressor variables are endogenous. While IV estimation is the standard textbook solution to mitigating endogeneity problems, the appropriateness of IV methods in typical accounting research settings is not obvious. Drawing on recent advances in statistics and econometrics, we identify conditions under which IV methods are preferred to OLS estimates and propose a series of tests for research studies employing IV methods. We illustrate these ideas by examining the relation between corporate disclosure and the cost of capital.
Blind Restoration of Remote Sensing Images by a Combination of Automatic Knife-Edge Detection and Alternating Minimization

In this paper, a blind restoration method is presented to remove the blur in remote sensing images. An alternating minimization (AM) framework is employed to simultaneously recover the image and the point spread function (PSF), and an adaptive-norm prior is used to apply different constraints to smooth regions and edges. Moreover, with the use of the knife-edge features in remote sensing images, an automatic knife-edge detection method is used to obtain a good initial PSF for the AM framework. In addition, a no-reference (NR) sharpness index is used to stop the iterations of the AM framework automatically at the best visual quality. Results in both simulated and real data experiments indicate that the proposed AM-KEdge method, which combines the automatic knife-edge detection and the AM framework, is robust, converges quickly, and can stop automatically to obtain satisfactory results.
Bur1 Kinase Is Required for Efficient Transcription Elongation by RNA Polymerase II

ABSTRACT The Saccharomyces cerevisiae cyclin-dependent kinase (CDK) Bur1 (Sgv1) may be homologous to mammalian Cdk9, which functions in transcriptional elongation. Although Bur1 can phosphorylate the Rpb1 carboxy-terminal domain (CTD) kinase in vitro, it has no strong specificity within the consensus heptapeptide YSPTSPS for Ser2 or Ser5. BUR1 mutants are sensitive to the drugs 6-azauracil and mycophenolic acid and interact genetically with the elongation factors Ctk1 and Spt5. Chromatin immunoprecipitation experiments show that Bur1 and its cyclin partner Bur2 are recruited to transcription elongation complexes, cross-linking to actively transcribing genes. Interestingly, Bur1 shows reduced cross-linking to transcribed regions downstream of polyadenylation sites. In addition, bur1 mutant strains have a reduced cross-linking ratio of RNA polymerase II at the 3′ end of genes relative to promoter regions. Phosphorylation of CTD serines 2 and 5 appears normal in mutant cells, suggesting that Bur1 is not a significant source of cotranscriptional Rpb1 phosphorylation. These results show that Bur1 functions in transcription elongation but may phosphorylate a substrate other than the CTD.
Urban heat island features of southeast Australian towns

The purpose of this investigation was to examine the current urban heat island (UHI) effect in a number of southeast Australian towns and to provide discussion on its potential impact on the historical temperature record. High-quality long-term historical temperature data are fundamental in the examination of climate change. Observational datasets are essential for the monitoring of climate and the analysis of past trends, and the validation of climate models. It is therefore necessary to account for any possible bias in the record due to non-climatic influences. Changes affecting the record, such as site moves and instrument modifications, have been addressed on both regional (e.g. Easterling and Peterson 1994; Plummer et al. 1995) and global (Jones et al. 1986; Karl and Williams 1987) scales. Aust. Met. Mag. 50 (2001) 1-13
Fourth-Order Cumulant-Based Blind Identification of Underdetermined Mixtures

In this paper we study two fourth-order cumulant-based techniques for the estimation of the mixing matrix in underdetermined independent component analysis. The first method is based on a simultaneous matrix diagonalization. The second is based on a simultaneous off-diagonalization. The number of sources that can be allowed is roughly quadratic in the number of observations. For both methods, explicit expressions for the maximum number of sources are given. Simulations illustrate the performance of the techniques
Stress Proliferation across Generations? Examining the Relationship between Parental Incarceration and Childhood Health

Stress proliferation theory suggests that parental incarceration may have deleterious intergenerational health consequences. In this study, I use data from the 2011–2012 National Survey of Children’s Health (NSCH) to estimate the relationship between parental incarceration and children’s fair or poor overall health, a range of physical and mental health conditions, activity limitations, and chronic school absence. Descriptive statistics show that children of incarcerated parents are a vulnerable population who experience disadvantages across an array of health outcomes. After adjusting for demographic, socioeconomic, and familial characteristics, I find that parental incarceration is independently associated with learning disabilities, attention deficit disorder and attention deficit hyperactivity disorder, behavioral or conduct problems, developmental delays, and speech or language problems. Taken together, results suggest that children’s health disadvantages are an overlooked and unintended consequence of mass incarceration and that incarceration, given its unequal distribution across the population, may have implications for population-level racial-ethnic and social class inequalities in children’s health.
Spatial And Sectoral Productivity Convergence Between European Regions, 1975-2000

This paper analyzes the evolution of labor productivity disparities among 145 European regions over 1975-2000 according to the concepts of sigma- and beta-convergence and emphasizes the importance of including both spatial effects and a disaggregated analysis at a sectoral level. We detect sigma-convergence in aggregate labor productivity and in the service sectors but not in the other sectors. This result can be explained by a transfer of resources from the agricultural sector to the more productive sectors that has been more marked in the poor regions. Empirical results also indicate that the common indicator of sigma-convergence lead to a bias when spatial effects are not included in the analysis. We then estimate beta-convergence models including the relevant spatial effects for each sector. The results show that inequality in productivity levels between core and peripheral regions persist and highlight how convergence speeds and the nature of spatial effects vary from one sector to another.
Hardware Synthesis of Weakly Consistent C Concurrency

Lock-free algorithms, in which threads synchronise not via coarse-grained mutual exclusion but via fine-grained atomic operations ('atomics'), have been shown empirically to be the fastest class of multi-threaded algorithms in the realm of conventional processors. This paper explores how these algorithms can be compiled from C to reconfigurable hardware via high-level synthesis (HLS). We focus on the scheduling problem, in which software instructions are assigned to hardware clock cycles. We first show that typical HLS scheduling constraints are insufficient to implement atomics, because they permit some instruction reorderings that, though sound in a single-threaded context, demonstrably cause erroneous results when synthesising multi-threaded programs. We then show that correct behaviour can be restored by imposing additional intra-thread constraints among the memory operations. We implement our approach in the open-source LegUp HLS framework, and provide both sequentially consistent (SC) and weakly consistent ('weak') atomics. Weak atomics necessitate fewer constraints than SC atomics, but suffice for many concurrent algorithms. We confirm, via automatic model-checking, that we correctly implement the semantics defined by the 2011 revision of the C standard. A case study on a circular buffer suggests that circuits synthesised from programs that use atomics can be 2.5x faster than those that use locks, and that weak atomics can yield a further 1.5x speedup.
The Capsid of Infectious Bursal Disease Virus Contains Several Small Peptides Arising from the Maturation Process of pVP2

ABSTRACT The capsid proteins VP2 and VP3 of infectious bursal disease virus, a birnavirus, are derived from the processing of a large polyprotein: NH2-pVP2-VP4-VP3-COOH. Although the primary cleavage sites at the pVP2-VP4 and VP4-VP3 junctions have been identified, the proteolytic cascade involved in the processing of this polyprotein is not yet fully understood, particularly the maturation of pVP2. By using different approaches, we showed that the processing of pVP2 (residues 1 to 512) generated VP2 and four small peptides (residues 442 to 487, 488 to 494, 495 to 501, and 502 to 512). We also showed that in addition to VP2, at least three of these peptides (residues 442 to 487, 488 to 494, and 502 to 512) were associated with the viral particles. The importance of the small peptides in the virus cycle was assessed by reverse genetics. Our results showed that the mutants lacking the two smaller peptides were viable, although the virus growth was affected. In contrast, deletions of the domain 442 to 487 or 502 to 512 did not allow virus recovery. Several amino acids of the peptide 502 to 512 appeared essential for virus viability. Substitutions of the P1 and/or P1" position were engineered at each of the cleavage sites (P1-P1": 441-442, 487-488, 494-495, 501-502, and 512-513). Most substitutions at the pVP2-VP4 junction (512-513) and at the final VP2 maturation cleavage site (441-442) were lethal. Mutations of intermediate cleavage sites (487-488, 494-495, and 501-502) led to viable viruses showing different but efficient pVP2 processing. Our data suggested that while peptides 488 to 494 and 495 to 501 play an accessory role, peptides 442 to 487 and 502 to 512 have an unknown but important function within the virus cycle.
Nouns and verbs as grammatical classes in the lexicon: 2680

The present study addresses the issue of the distinction between nouns and verbs in the lexicon and investigates if and to what extent the grammatical properties of nouns and verbs play a role in organizing the lexical knowledge. Evidence from linguistics, cognitive psychology and cognitive neuropsychology of language is reviewed in order to support the conclusions that, among many other dimensions, nouns and verbs are represented as grammatical classes in speakers’ lexical knowledge. Furthermore, the grammatical knowledge of the two classes of words plays the role of an organizational principle in the lexicon, and contributes to explain the organization and the format of words’ representations as well as their possible neural and functional damages * .
Molecular and phylogenetic characterization of Ornithobacterium rhinotracheale isolates from turkey, quail, partridge and domestic pigeon in Iran.

Ornithobacterium rhinotracheale (ORT) is a respiratory pathogen which has been isolated throughout the world from numerous bird species. The present study was designed to investigate molecular and phylogenetic characterization of ORT isolates from turkey, quail, partridge and domestic pigeon. For this purpose, one bacterial strain from each bird species which was isolated in a previous work was compared with chicken and some other bird species isolates. Isolates were streaked on 5% sheep blood agar containing gentamicin. Genomic DNA was extracted from fresh cultures by boiling of bacteria suspension. PCR was performed by using of specific primers for partial amplification of 16S rRNA gene. PCR products of ORT isolates were sequenced in both directions by an automatic sequencer. Our ORT isolates showed high identity (98.1% to 100%) in sequence of 16S rRNA gene to related data in GenBank. Phylogenetic analysis of these sequences showed that Iranian turkey and pigeon isolates were classified into a distinctive cluster with pigeon isolates from Taiwan, while Iranian quail and partridge isolates showed more relationship with the native isolates of chicken as well as some foreign isolates from different sources in the GenBank.
A Preliminary Look at the Privacy of SSH Tunnels

Secure Shell (SSH) tunnels are commonly used to provide two types of privacy protection to clear-text application protocols. First and foremost, they aim at protecting the privacy of the data being exchanged between two peers, such as passwords, details of monetary transactions and so on. Second, they are supposed to protect the privacy of the behavior of end-users, by preventing an unauthorized observer from detecting which application protocol is being transported by an SSH tunnel. In this paper we introduce a GMM-based (Gaussian Mixture Model) technique that, under a set of reasonable assumptions, can be used to identify which application is being tunneled inside an SSH session by simply observing the stream of encrypted packets. This technique can therefore break the presumption of privacy in its second incarnation as described above. Although still preliminary, experimental results show that the technique can be quite effective, and that the standard bodies might need to take this approach under consideration when designing new obfuscation techniques for SSH.
Pilot Assessment of Brain Metabolism in Perinatally HIV-Infected Youths Using Accelerated 5D Echo Planar J-Resolved Spectroscopic Imaging

Purpose To measure cerebral metabolite levels in perinatally HIV-infected youths and healthy controls using the accelerated five dimensional (5D) echo planar J-resolved spectroscopic imaging (EP-JRESI) sequence, which is capable of obtaining two dimensional (2D) J-resolved spectra from three spatial dimensions (3D). Materials and Methods After acquisition and reconstruction of the 5D EP-JRESI data, T1-weighted MRIs were used to classify brain regions of interest for HIV patients and healthy controls: right frontal white (FW), medial frontal gray (FG), right basal ganglia (BG), right occipital white (OW), and medial occipital gray (OG). From these locations, respective J-resolved and TE-averaged spectra were extracted and fit using two different quantitation methods. The J-resolved spectra were fit using prior knowledge fitting (ProFit) while the TE-averaged spectra were fit using the advanced method for accurate robust and efficient spectral fitting (AMARES). Results Quantitation of the 5D EP-JRESI data using the ProFit algorithm yielded significant metabolic differences in two spatial locations of the perinatally HIV-infected youths compared to controls: elevated NAA/(Cr+Ch) in the FW and elevated Asp/(Cr+Ch) in the BG. Using the TE-averaged data quantified by AMARES, an increase of Glu/(Cr+Ch) was shown in the FW region. A strong negative correlation (r < -0.6) was shown between tCh/(Cr+Ch) quantified using ProFit in the FW and CD4 counts. Also, strong positive correlations (r > 0.6) were shown between Asp/(Cr+Ch) and CD4 counts in the FG and BG. Conclusion The complimentary results using ProFit fitting of J-resolved spectra and AMARES fitting of TE-averaged spectra, which are a subset of the 5D EP-JRESI acquisition, demonstrate an abnormal energy metabolism in the brains of perinatally HIV-infected youths. This may be a result of the HIV pathology and long-term combinational anti-retroviral therapy (cART). Further studies of larger perinatally HIV-infected cohorts are necessary to confirm these findings.
A computational model of the integration of landmarks and motion in the insect central complex

The insect central complex (CX) is an enigmatic structure whose computational function has evaded inquiry, but has been implicated in a wide range of behaviours. Recent experimental evidence from the fruit fly (Drosophila melanogaster) and the cockroach (Blaberus discoidalis) has demonstrated the existence of neural activity corresponding to the animal’s orientation within a virtual arena (a neural ‘compass’), and this provides an insight into one component of the CX structure. There are two key features of the compass activity: an offset between the angle represented by the compass and the true angular position of visual features in the arena, and the remapping of the 270° visual arena onto an entire circle of neurons in the compass. Here we present a computational model which can reproduce this experimental evidence in detail, and predicts the computational mechanisms that underlie the data. We predict that both the offset and remapping of the fly’s orientation onto the neural compass can be explained by plasticity in the synaptic weights between segments of the visual field and the neurons representing orientation. Furthermore, we predict that this learning is reliant on the existence of neural pathways that detect rotational motion across the whole visual field and uses this rotation signal to drive the rotation of activity in a neural ring attractor. Our model also reproduces the ‘transitioning’ between visual landmarks seen when rotationally symmetric landmarks are presented. This model can provide the basis for further investigation into the role of the central complex, which promises to be a key structure for understanding insect behaviour, as well as suggesting approaches towards creating fully autonomous robotic agents.
Using Strategy Improvement to Stay Alive

We design a novel algorithm for solving Mean-Payoff Games (MPGs). Besides solving an MPG in the usual sense, our algorithm computes more information about the game, information that is important with respect to applications. The weights of the edges of an MPG can be thought of as a gained/consumed energy – depending on the sign. For each vertex, our algorithm computes the minimum amount of initial energy that is sufficient for player Max to ensure that in a play starting from the vertex, the energy level never goes below zero. Our algorithm is not the first algorithm that computes the minimum sufficient initial energies, but according to our experimental study it is the fastest algorithm that computes them. The reason is that it utilizes the strategy improvement technique which is very efficient in practice.
Psychological Capital and Employee Performance in Federal Neuro-Psychiatric Hospital, Benn City, Edo State, Nigeria

Declining employees’ performance has emerged as part of the criticisms leveled against government hospitals in Nigeria. Perhaps, the problem of employees apathy and lack of effort is not simply a matter of individual laziness, rather there are often healthy reaction by normal people to an unhealthy environment created by uncommon organizational or government policies. This underscores the importance of investing in and developing the positive psychological capacities of organizational members for the benefit of boosting organizational performance and remains competitive. This study therefore examines the relationship between psychological capital and employee performance in Federal Neuro-Psychiatric Hospital in Benin City using survey research method. A sample size of one hundred and twenty two (122) was selected for the study using accidental sampling technique. Data collected were analyzed using Pearson product moment correlation and multiple regression analysis. The study found that there is significant relationship between psychological capital and employee performance in Federal Neuro-Psychiatric Hospital Benin City, Edo State, Nigeria. Requisite conclusion and recommendations were provided in the light of empirical and theoretical findings.