Miracle-dz/UniFAR-FTUs huggingface dataset:
Alexithymia and Sense of Coherence in Patients With Total Spinal Cord Transection

Objective The study investigated the possibility that total spinal cord transection leading to tetraplegia would affect the ability to experience and identify emotions. It also examined whether the dispositional orientation of “sense of coherence” contributed to self-rated quality of life after spinal cord transection. Methods Twenty patients with total spinal cord transection at the level of the sixth cervical vertebrae and 20 age- and sex-matched healthy control subjects completed measures of alexithymia, sense of coherence, and quality of life. Results There were no differences between the two groups on alexithymia scores. However, spinal injury patients reported significantly decreased quality of life relative to matched healthy control subjects. A strong sense of coherence was associated with better self-reported quality of life. This relationship remained after controlling for current affective status. Conclusions We conclude that 1) loss of afferent feedback to the brain via the spinal cord does not have a significant effect on alexithymia scores, particularly factor 1 (difficulty in identifying feelings), and 2) sense of coherence may be an important factor in determining psychological adjustment after serious injury.
Unsupervised Labeling for Supervised Anomaly Detection in Enterprise and Cloud Networks

Identifying anomalous events in the network is one of the vital functions in enterprises, ISPs, and datacenters to protect the internal resources. With its importance, there has been a substantial body of work for network anomaly detection using supervised and unsupervised machine learning techniques with their own strengths and weaknesses. In this work, we take advantage of the both worlds of unsupervised and supervised learning methods. The basic process model we present in this paper includes (i) clustering the training data set to create referential labels, (ii) building a supervised learning model with the automatically produced labels, and (iii) testing individual data points in question using the established learning model. By doing so, it is possible to construct a supervised learning model without the provision of the associated labels, which are often not available in practice. To attain this process, we set up a new property defining anomalies in the context of clustering, based on our observations from anomalous events in network, by which the referential labels can be obtained. Through our extensive experiments with a public data set (NSL-KDD), we will show that the presented method perform very well, yielding fairly comparable performance to the traditional method running with the original labels provided in the data set, with respect to the accuracy for anomaly detection.
Framing and temporality in political cartoons: A critical analysis of visual news discourse

Les caricatures politiques constituent une forme visuelle du discours des medias. Les sociologues rejettent generalement leur valeur ideologique en raison du fait qu'elles offrent aux lecteurs des exposes absurdes des conditions du « probleme » putatif et ne doivent pas etre prises au pied de la lettre. Toutefois, c'est par l'humour que les caricatures se sont emparees du bon sens et l'ont renfonce, et par consequent ont permis au public de classifier, d'organiser et d'inter-preter activement ce qu'ils percoivent ou vivent relativement a l'actu-alite dans le monde a un moment donne de facon significative. Dans le cadre des theories interactionnistes de Goffman et de Mead, deux caricatures illustrant la derniere « crise » des « vagues d'immigration » deferlant au Canada seront etudiees. Political cartoons are a form of visual news discourse. Sociologists normally dismiss their ideological import on the grounds that cartoons simply offer newsreaders absurd accounts of putative “problem” conditions and are not likely to be taken very seriously. Nevertheless, it is through comedic conventions that cartoons seize upon and reinforce common sense and thus enable the public to actively classify, organize and interpret in meaningful ways what they see or experience about the world at a given moment. Informed by the interactionist theories of Goffman and Mead, two cartoons illustrating the recent “crisis” of “migrant waves” to Canada will be examined.
A Common Minimal Motif for the Ligands of HLA-B*27 Class I Molecules

CD8+ T cells identify and kill infected cells through the specific recognition of short viral antigens bound to human major histocompatibility complex (HLA) class I molecules. The colossal number of polymorphisms in HLA molecules makes it essential to characterize the antigen-presenting properties common to large HLA families or supertypes. In this context, the HLA-B*27 family comprising at least 100 different alleles, some of them widely distributed in the human population, is involved in the cellular immune response against pathogens and also associated to autoimmune spondyloarthritis being thus a relevant target of study. To this end, HLA binding assays performed using nine HLA-B*2705-restricted ligands endogenously processed and presented in virus-infected cells revealed a common minimal peptide motif for efficient binding to the HLA-B*27 family. The motif was independently confirmed using four unrelated peptides. This experimental approach, which could be easily transferred to other HLA class I families and supertypes, has implications for the validation of new bioinformatics tools in the functional clustering of HLA molecules, for the identification of antiviral cytotoxic T lymphocyte responses, and for future vaccine development.
Applicability of the ICF checklist to traumatically brain-injured patients in post-acute rehabilitation settings.

OBJECTIVE To evaluate the applicability of the International Classification of Functioning, Disability and Health (ICF) checklist in post-acute traumatically brain-injured patients in rehabilitation settings. DESIGN A cross-sectional study based on the written documents of an interdisciplinary rehabilitation team. SUBJECTS A sample of 55 patients with traumatic brain injury. METHODS Two raters extracted information from the patients' medical documents using the ICF checklist. The most common ICF categories were identified and the agreement between the raters was evaluated. RESULTS Of the 123 checklist categories, 30 reached a prevalence of 30% or more in the ratings of both raters, and 18 further categories reached a prevalence of 30% or more in the ratings of either one rater. Seventy-five categories (61%) did not reach the cut-off point and were thus considered irrelevant. Fourteen ICF categories not included in the checklist were also considered important. Extracting the data from pre-existing documents seems to be reliable: in 86% of the most relevant categories the difference between the raters in the qualifier values was at most 1. CONCLUSION A checklist is a practical tool in clinical work. However, the current ICF checklist seems not to be adequate in characterizing patients with post-acute traumatic brain injury. Developing an ICF core set for these patients might prove useful.
Expletives of lower working-class women

ABSTRACT For many decades, women's speech has been seen as being very different from that used by men. Stereotyped as swearing less, using less slang, and as aiming for more standard speech style, women were judged according to their sex rather than other aspects of their lives, such as class and economic situation. With many critics now challenging these ideas, this article sets out to look at the reality of the swearing used by a group of women from a deprived inner-city area. Their constant use of strong expletives flies in the face of the theories proffered of the “correctness” of the language of women. (Expletives, taboo words, working-class women, female speech, female group, social networks, sociolinguistics, inner-city England)
Optimization over polynomials: Selected topics

Minimizing a polynomial function over a region defined by polynomial inequalities models broad classes of hard problems from combinatorics, geometry and optimization. New algorithmic approaches have emerged recently for computing the global minimum, by combining tools from real algebra (sums of squares of polynomials) and functional analysis (moments of measures) with semidefinite optimization. Sums of squares are used to certify positive polynomials, combining an old idea of Hilbert with the recent algorithmic insight that they can be checked efficiently with semidefinite optimization. The dual approach revisits the classical moment problem and leads to algorithmic methods for checking optimality of semidefinite relaxations and extracting global minimizers. We review some selected features of this general methodology, illustrate how it applies to some combinatorial graph problems, and discuss links with other relaxation methods.
Finding long and similar parts of trajectories

A natural time-dependent similarity measure for two trajectories is their average distance at corresponding times. We give algorithms for computing the most similar subtrajectories under this measure, assuming the two trajectories are given as two polygonal, possibly self-intersecting lines. When a minimum duration is specified for the subtrajectories, and they must start at exactly corresponding times in the input trajectories, we give a linear-time algorithm for computing the starting time and duration of the most similar subtrajectories. The algorithm is based on a result of independent interest: We present a linear-time algorithm to find, for a piece-wise monotone function, an interval of at least a given length that has minimum average value. When the two subtrajectories can start at different times in the two input trajectories, it appears difficult to give an exact algorithm for the most similar subtrajectories problem, even if the duration of the desired two subtrajectories is fixed to some length. We show that the problem can be solved approximately, and with a performance guarantee. More precisely, we present (1 + ε)-approximation algorithms for computing the most similar subtrajectories of two input trajectories for the case where the duration is specified, and also for the case where only a minimum on the duration is specified.
Effect of gap junction uncoupling in full-grown Bufo arenarum ovarian follicles: participation of cAMP in meiotic arrest

The aim of the present study was to determine the presence of the connexins Cx43, Cx32 and Cx26 in Bufo arenarum ovarian follicles during the breeding season as well as to analyse the possible alterations in the meiotic process when connexins are blocked by specific antibodies. Western blot analysis revealed that the Cx43 and Cx32 proteins were present but not Cx26. We demonstrated that the anti-Cx43 and anti-Cx32 antibodies produced the uncoupling of the gap junctions. When these junctions are blocked the maturation process is triggered in the oocytes. We determined that dbcAMP exerts an inhibitory effect on the maturation induced by the uncoupling of the gap junctions when the oocytes are injected or pretreated with this metabolite. We propose the idea that cAMP is the regulatory molecule in meiotic arrest in this amphibian species.
Acute Migraine Treatment in Emergency Settings Executive Summary

Migraine is a chronic neurovascular disorder characterized by dysfunction of the central and peripheral nervous systems and intracranial vasculature.1 Acute exacerbations of episodic and chronic migraine cause severe and disabling pain that often results in visits to an emergency department (ED), as well as decreased productivity and missed time from work, school, and other activities.2 Migraine has a negative impact on overall quality of life3 and is associated with psychiatric and medical comorbidities.4,5 In the United States, migraine and related medical issues result in costs of more than $13 billion per year due to lost productivity.6
The neuroanatomy of bilingualism: how to turn a hazy view into the full picture

ABSTRACT The neuroanatomical bases of bilingualism have recently received intensive attention. However, it is still a matter of debate how the brain structure changes due to bilingual experience since current findings are highly variable. The aim of this review is to examine these structural studies from a methodological perspective and to discuss two major methodological problems that could give rise to this variability. The first problem is sample selection, an issue directly related to the heterogeneous nature of bilingualism. The second problem is the inconsistency in the methods used for the analysis of brain imaging data. This review reveals that although structural changes related to bilingualism have been reported in regions comprising language/cognitive control and language processing, these results are not yet sufficiently numerous or consistent to allow important generalizations to be reached. Consequently, current evidence offers ambiguous support for neural models of bilingualism. This shortcoming in the field is exacerbated by critical methodological differences between studies that only further complicate the matter. We conclude by identifying issues that should be taken into consideration so that studies are more comparable and results are easier to aggregate and interpret. We also point out future directions that would allow for progress in the field.
New Sports Stadiums, Community Self-Esteem, and Community Collective Conscience

Sports economists have created a sizable literature on the costs and benefits of publicly funded major-league sports stadiums. This research suggests a growing consensus that stadiums provide little economic advantage for local communities. In response, some stadium supporters have modified their tactics to increasingly avoid claims of tangible economic benefits. Instead, they insist that new stadiums offer communities more intangible social benefits. These alleged intangible benefits can take many specific forms but usually have something to do with a community’s self esteem or its collective conscience. This article draws on the authors’ primary research in 10 U.S. cities that are involved in different stages of new stadium construction. The authors demonstrate how local elites socially construct ideas such as community self-esteem and community collective conscience to help them reap large amounts of public dollars for their private stadiums.
The Nuclear Exosome Is Active and Important during Budding Yeast Meiosis

Nuclear RNA degradation pathways are highly conserved across eukaryotes and play important roles in RNA quality control. Key substrates for exosomal degradation include aberrant functional RNAs and cryptic unstable transcripts (CUTs). It has recently been reported that the nuclear exosome is inactivated during meiosis in budding yeast through degradation of the subunit Rrp6, leading to the stabilisation of a subset of meiotic unannotated transcripts (MUTs) of unknown function. We have analysed the activity of the nuclear exosome during meiosis by deletion of TRF4, which encodes a key component of the exosome targeting complex TRAMP. We find that TRAMP mutants produce high levels of CUTs during meiosis that are undetectable in wild-type cells, showing that the nuclear exosome remains functional for CUT degradation, and we further report that the meiotic exosome complex contains Rrp6. Indeed Rrp6 over-expression is insufficient to suppress MUT transcripts, showing that the reduced amount of Rrp6 in meiotic cells does not directly cause MUT accumulation. Lack of TRAMP activity stabilises ∼1600 CUTs in meiotic cells, which occupy 40% of the binding capacity of the nuclear cap binding complex (CBC). CBC mutants display defects in the formation of meiotic double strand breaks (DSBs), and we see similar defects in TRAMP mutants, suggesting that a key function of the nuclear exosome is to prevent saturation of the CBC complex by CUTs. Together, our results show that the nuclear exosome remains active in meiosis and has an important role in facilitating meiotic recombination.
A Prospective, Randomized Comparison of Promus Everolimus-Eluting and TAXUS Liberte Paclitaxel-Eluting Stent Systems in Patients with Coronary Artery Disease Eligible for Percutaneous Coronary Intervention: The PROMISE Study

We aimed comparing two-year clinical outcomes of the Everolimus-Eluting Promus and Paclitaxel-Eluting TAXUS Liberte stents used in routine clinical practice. Patients with objective evidence of ischemia and coronary artery disease eligible for PCI were prospectively randomized to everolimus-eluting stent (EES) or paclitaxel-eluting stent (PES) groups. The primary end-point was ischemia-driven target vessel revascularization (TVR) at 2 yr after intervention, and the secondary end-point was a major adverse cardiac event (MACE), such as death, myocardial infarction (MI), target lesion revascularization (TLR), TVR or stent thrombosis. A total of 850 patients with 1,039 lesions was randomized to the EES (n=425) and PES (n=425) groups. Ischemic-driven TVR at 2 yr was 3.8% in the PES and 1.2% in the EES group (P for non-inferiority=0.021). MACE rates were significantly different; 5.6% in PES and 2.5% in EES (P = 0.027). Rates of MI (0.8% in PES vs 0.2% in EES, P = 0.308), all deaths (1.5% in PES vs 1.2% in EES, P = 0.739) and stent thrombosis (0.3% in PES vs 0.7% in EES, P = 0.325) were similar. The clinical outcomes of EES are superior to PES, mainly due to a reduction in the rate of ischemia-driven TVR.
Discovery of novel frizzled-7 inhibitors by targeting the receptor’s transmembrane domain

Frizzled (Fzd) proteins are seven transmembrane receptors that belong to a novel and separated family of G-protein-coupled receptors (GPCRs). The Fzd receptors can respond to Wnt proteins to activate the canonical β-catenin pathway which is important for both initiation and progression of cancers. Disruption of the Wnt/β-catenin signal thus represents an opportunity for rational cancer prevention and therapy. Of the 10 members of the Fzd family, Fzd7 is the most important member involved in cancer development and progression. In the present studies, we applied structure-based virtual screening targeting the transmembrane domain (TMD) of Fzd7 to select compounds that could potentially bind to the Fzd7-TMD and block the Wnt/Fzd7 signaling and further evaluated them in biological assays. Six small molecule compounds were confirmed as Fzd7 inhibitors. The best hit, SRI37892, significantly blocked the Wnt/Fzd7 signaling with IC50 values in the sub-micromolar range and inhibited cancer cell proliferation with IC50 values around 2 μM. Our results provide the first proof of concept of targeting Fzd-TMD for the development of Wnt/Fzd modulators. The identified small molecular Fzd7 inhibitors can serve as a useful tool for studying the regulation mechanism(s) of Wnt/Fzd7 signaling as well as a starting point for the development of cancer therapeutic agents.
The impact of news announcements on volatility spillovers : International evidence from implied volatility markets *

This paper investigates the role of scheduled news announcements in explaining the transmission of volatility, both within European markets and across U.S. and European ones. To this end, a novel approach is taken by employing a set of widely followed implied volatility indices. Aggregate, regional, and individual event dummies and surprise measures for U.S. and European news announcements are constructed. We find that implied volatility spillovers exist between U.S. and European markets and within European countries. Furthermore, these volatility linkages continue to show up even after the effect of news announcements is taken into account. In this case, aggregate and regional releases account partially for the reported volatility spillovers. Finally, aggregate and regional releases affect also the magnitude of volatility spillovers when their content is considered. These findings are consistent with the market efficiency hypothesis for option markets. JEL Classification: G13, G14, G15
A Double-Blind, Placebo-Controlled Clinical Trial of Fluoxetine in Geriatric Patients With Major Depression

Depression in the geriatric population is a frequents, serious, and potentially reversible disorder, yet relatively few blinded, controlled, antidepressant trial have been reported. A number of age-related issues complicate safe and effective pharmacotherapy. In a 6-week, double-blind trial in moderately to severely depressed (nonpsychotic) outpatients over age 60, fluoxetine (N = 335) was statistically significantly more efficacious than placebo (N = 336) in overall response (43.9% vs. 31.6%, p = .002) and remission (31.6% vs. 18.6%, p < .001) rates. Analyses of early discontinuations because of an adverse drug event revealed no statistically significantly greater rate with fluoxetine (n = 39; 11.6%) than was seen with placebo (n = 29; 8.6%). These results corroborate that major depression in an older population is responsive to antidepressant pharmacotherapy. Specifically, fluoxetine, at a conventional 20-mg dose, was both safe and effective relative to placebo in this special population.
Reasons for non-attendance: audit findings from a nurse-led clinic.

BACKGROUND AND CONTEXT Evidence has shown that non-attendance at clinics occurs for a variety of reasons and impacts negatively on client outcomes and effective use of clinic resources. This paper reports an audit of non-attendance at Care Plus and diabetes clinics undertaken between October 2007 and October 2008, in a large general practice in the Wellington region. ASSESSMENT OF PROBLEM A retrospective and prospective audit of the non-attendance rate at nurse-led wellness clinics was completed using the Query Builder function in Medtech32, collecting data from 142 people who did not attend a scheduled appointment. RESULTS Thirty-three people were unable to be contacted about their reason for not attending. Of those contacted, 68 did not attend because they were unaware of the appointment, confused regarding the appointment time, or simply forgot. Eighty-four people were aged between 18 and 65 years, yet of those contacted, only four cited work had prevented their attendance at the clinic. Difficulty with transport was reported by only two people. STRATEGIES FOR IMPROVEMENT The audit highlighted the importance of administration processes for scheduling routine appointments and reminding patients about appointments. It provided evidence that administrative support for nurse-led clinics is necessary. LESSONS Involvement in clinical audit was a new experience for many of the staff and the usefulness of the findings led to more positive views about how audit can be used. The importance of appropriate administrative support was highlighted. Lessons learned for future audits included the importance of a complete data set and consistent use of codes for data entry.