Miracle-dz/UniFAR-FTUs huggingface dataset:
Inception Score, Label Smoothing, Gradient Vanishing and -log(D(x)) Alternative

In this article, we mathematically study several GAN related topics, including Inception score, label smoothing, gradient vanishing and the -log(D(x)) alternative. --- An advanced version is included in arXiv:1703.02000 "Activation Maximization Generative Adversarial Nets". Please refer Section 6 in 1703.02000 for detailed analysis on Inception Score, and refer its appendix for the discussions on Label Smoothing, Gradient Vanishing and -log(D(x)) Alternative.
Automatic Facial Expression Recognition System Using Deep Network-Based Data Fusion

This paper presents a novel automatic facial expressions recognition system (AFERS) using the deep network framework. The proposed AFERS consists of four steps: 1) geometric features extraction; 2) regional local binary pattern (LBP) features extraction; 3) fusion of both the features using autoencoders; and 4) classification using Kohonen self-organizing map (SOM)-based classifier. This paper makes three distinct contributions. The proposed deep network consisting of autoencoders and the SOM-based classifier is computationally more efficient and performance wise more accurate. The fusion of geometric features with LBP features using autoencoders provides better representation of facial expression. The SOM-based classifier proposed in this paper has been improved by making use of a soft-threshold logic and a better learning algorithm. The performance of the proposed approach is validated on two widely used databases (DBs): 1) MMI and 2) extended Cohn–Kanade (CK+). An average recognition accuracy of 97.55% in MMI DB and 98.95% in CK+ DB are obtained using the proposed algorithm. The recognition results obtained from fused features are found to be distinctly superior to both recognition using individual features as well as recognition with a direct concatenation of the individual feature vectors. Simulation results validate that the proposed AFERS is more efficient as compared to the existing approaches.
Prediction of hot regions in protein-protein interactions based on complex network and community detection

In the protein-protein interactions (PPI), hot regions are the key factor to maintain metabolism and the cause of disease. The conformation and prediction of the hot regions effectively is a worth researching topics. This paper proposes a prediction method of hot regions based on complex network and community detection. In the prediction process, a hotspots retrieving strategy is used to exploit false positive (FP) and false negative (FN) residues, and these FP and FN residues achieved from the previous hotspots prediction. The method has advantage to identify hot regions in PPI, and experimental results show that the method not only improves the prediction accuracy of hot regions, but also has more reliability.
Short-term effectiveness of a community health worker intervention for HIV-infected pregnant women in Tanzania to improve treatment adherence and retention in care: A cluster-randomized trial

Introduction Community health workers (CHWs) are lay workers who have the potential to enhance services to prevent mother-to-child HIV transmission (PMTCT) and improve the health of women living with HIV infection. We conducted a cluster-randomized trial of an intervention to integrate CHWs with ‘Option B+’ PMTCT services in Shinyanga Region, Tanzania. Methods The intervention was implemented for 11 months and included four integrated components: 1) formal linkage of CHWs to health facilities; 2) CHW-led antiretroviral therapy (ART) adherence counseling; 3) loss to follow-up tracing by CHWs; and 4) distribution of Action Birth Cards (ABCs), a birth planning tool. We cluster-randomized 32 facilities offering PMTCT services, within strata of size, to the intervention (n = 15) or comparison (standard of care, n = 17) groups. Intervention effectiveness was determined with a difference-in-differences strategy based on clinical and pharmacy data from HIV-infected postpartum women at baseline (births in 2014) and endline (births April-Oct 2015). The primary outcome was retention in care between 60 and 120 days postpartum. Secondary outcomes included ART initiation, timing of ART initiation (as measured by week of gestation), and ART adherence 90 days postpartum, measured using the medication possession ratio (MPR≥95%). Results Intervention and comparison facilities were similar at baseline. Data were collected from 1,152 and 678 mother-infant pairs at baseline and endline, respectively. There were no significant differences in retention in care, ART initiation, or timing of ART initiation between the intervention and control groups. Adherence (MPR≥95%) at 90 days postpartum was 11.3 percentage points higher in the intervention group in ITT analyses (95% CI: -0.7, 23.3, p = 0.06), though this effect was attenuated after adjusting for baseline imbalance (9.5 percentage points, 95% CI: -2.9, 22.0, p = 0.13). Among only sites that had the greatest fidelity to the intervention, however, we found a stronger effect on adherence (13.6 percentage points, 95% CI: 2.5, 24.6). Conclusions Despite being feasible and acceptable, the CHW-based intervention did not have strong effects on most PMTCT indicators. CHW involvement in PMTCT programs may improve ART adherence among HIV-infected postpartum women, however, and success appears heavily dependent on program implementation. Trial registration Registry for International Development Impact Evaluations (RIDIE, ID 552553838b402) and ClinicalTrials.gov (NCT03058484)
Self-Rated Health, Activities of Daily Living, and Mobility Limitations Among Black and White Stroke Survivors

Objective: To explore racial differences in self-rated health (SRH) and its relationship to activities of daily living (ADLs) and mobility limitations among stroke survivors. Method: Data from 580 Black and White participants of the North Carolina Established Populations for Epidemiologic Studies of the Elderly (EPESE) were used to assess relationships between SRH, ADLs, and mobility variables. Fisher's exact tests, t tests, and logistic regression with backward selection (p < .20) were used. Results: No racial difference in SRH was found. SRH was significant in predicting ADL status among Whites only (OR = 0.23; CI = 0.08-0.69; p < .01). Participants older than 75 years had a greater likelihood of being in the lowest functioning ADL categories (OR = 2.31; CI = 1.48-3.60; p < .01). Discussion: Though no racial differences in SRH were found, the relationship between SRH, ADLs, and mobility status was moderated by race. SRH was predictive of limitations in Whites only. Observed differences suggest SRH construct may differ by race.
Effect of aqueous extract of Loranthus micranthus ( mistletoe ) on total protein , catalase and NOS activity in the kidney of albino rats induced with Pb

The effect of aqueous extract of Loranthus micranthus on the kidney of albino rat induced with Lead acetate on catalase activity, nitric oxide scavenging (NOS) activity and total protein was investigated. 30 albino rats were used and they were divided into 6 groups. 200 mg/kg of lead acetate was injected intraperitoneally into the rats to intoxify and the extract was administered orally as a therapeutic agent. Group1(Negative control) received a normal rat feed, while group 2 to 5 were intoxified and given 500 m/kg,100 mg/kg,1500 mg/kg, 2000 mg/kg of extract respectively and group 6 serves as the positive control (without treatment). Duration of the experiment lasted for 3 weeks. Results indicate that at low concentration, extract significantly ameliorates total protein, nitric oxide radical scavenging activity (RSA), catalase activity (p<0.05). 500 mg/kg of mistletoe extract significantly ameliorated the altered level of total protein, catalase activity and nitric oxide RSA status in group 2 when compared to group 6. The extract possessed antioxidant activity as seen from the ameliorating effect on oxidative stress in intoxicated rat. Therefore, it can be deduced that mistletoe extract has the potential of ameliorating the altered protein synthesis and antioxidant activity in a dose dependent manner. Keyword: Catalase, protein, activity, kidney, albino rats.
Comparative analysis of DNA methylation patterns of equine sarcoid and healthy skin samples

OBJECTIVE In this study, for the first time we report the genome-wide DNA methylation profile of skin tumour in horses and describe differentially methylated genomic regions (DMRs) with respect to healthy skin. MATERIALS & METHODS The comparative analysis of DNA methylation patterns detected using Reduced Representation Bisulfite Sequencing (RRBS) technique, allowed identification of 136 regions showing differential methylation between sarcoid and normal skin tissue. RESULTS Most of the identified DMRs were short fragments, less than 1 kb in size, located in the intergenic regions. Among identified DMRs there were also regions located within genes directly or indirectly related with oncogenesis. We additionally validated 9 CpG sites showing hypomethylation and 9 CpG sites that were hypermethylated in lesional sample, confirming the identified changes in the DNA methylation. CONCLUSION Knowledge on the changes taking place in the process of DNA methylation may provide a basis for the development of new alternative diagnostic or therapeutic approaches to equine sarcoids.
Quality of life among patients during subacute phase following stroke during hospitalisation period in Shanghai

Abstract Objective: This study aimed to investigate the factors influencing the quality of life of in-hospital subacute stroke patients. Methods: The patients of subacute stroke (within four weeks) in our institution between 2015 and 2016 were recruited. Patients’ characteristics and QOL were obtained from medical charts and stroke-specific quality of life scale (SS-QOL). Associations of each domain in SS-QOL with socio-demographic, clinical factors and patient satisfaction were investigated using the linear regression models. Results: Among the 203 subjects, 60 were diagnosed as large artery atherosclerosis (LAA), 80 were small-artery occlusion (SAO), 28 were cardioembolism (CE) and 35 were intracranial haemorrhage (ICH). The ICH group had the worst self-care ability and upper extremity function. Worse severity of stroke was associated with lower levels of language ability, mobility, mood status and upper-extremity function. Participants who had better satisfaction had high levels of capability of conducting family roles, positive emotions, personality consistency, self-care ability and capacity of conducting social roles. Conclusions: The level of patient satisfaction, duration of hospitalisation and the severity of stroke were found to be the three important factors associated with SS-QOL at hospital discharge, indicating doctors might assist patients adjust to the consequences of stroke and improve the QOL of subacute stroke.
MIX PROPORTIONS AND PROPERTIES OF POLYESTER RESIN CONCRETE

Polyester resin concrete is a type of concrete that is prepared by binding aggregate with polyester resin (as a binder) without inorganic cements. The mix proportions of polyester resin concrete have not been studied systematically until now. This paper contains a summary of the method used to obtain the most satisfactory mix proportion of polyester resin concrete and a discussion on the properties of this concrete. /ACI/
Synthesis in Distributed Environments

Most approaches to the synthesis of reactive systems study the problem in terms of a two-player game with complete observation. In many applications, however, the system's environment consists of several distinct entities, and the system must actively communicate with these entities in order to obtain information available in the environment. In this paper, we model such environments as a team of players and keep track of the information known to each individual player. This allows us to synthesize programs that interact with a distributed environment and leverage multiple interacting sources of information. The synthesis problem in distributed environments corresponds to solving a special class of Petri games, i.e., multi-player games played over Petri nets, where the net has a distinguished token representing the system and an arbitrary number of tokens representing the environment. While, in general, even the decidability of Petri games is an open question, we show that the synthesis problem in distributed environments can be solved in polynomial time for nets with up to two environment tokens. For an arbitrary but fixed number of three or more environment tokens, the problem is NP-complete. If the number of environment tokens grows with the size of the net, the problem is EXPTIME-complete.
The gastrointestinal tract of farmed mink (Neovison vison) maintains a diverse mucosa‐associated microbiota following a 3‐day fasting period

Although it is well documented that the gut microbiota plays an important role in health and disease in mammalian species, this area has been poorly studied among carnivorous animals, especially within the mustelidae family. The gastrointestinal tract of carnivores is characterized by its short length and fast transit time, as compared to omnivores and herbivores, which is due to the low level of inherent fermentation. Mink represents an example of this, which have a GI tract only four times the length of the body and a transit time of approximately 4–5 hr. In this study, we used high‐throughput 16S rRNA gene sequencing to explore the resident gut microbiota of the mink in terms of intra‐and interindividual diversity. We report, for the first time, that the mucosa‐associated bacterial community within the colon is diverse and dissimilar from the community found in the feed. We found large interindividual differences in bacterial composition between individual animals being dominated generally by the phylum Firmicutes, but in some cases also Proteobacteria or Fusobacteria. The bacterial load and community structure within the mucus was not severely impacted by 3 days of fasting, which implies that a resident and stable microbiota is hosted by these animals.
Assessment of bone turnover markers and bone mineral density in normal short boys

Abstract Aim: To investigate whether there is a change in bone turnover-related biochemical markers and bone mineral density of children with constitutional delay of growth and puberty (CDGP) in the prepubertal period. Methods: We measured serum calcium, phosphorus, alkaline phosphatase, parathormone, 25-OH vitamin D, osteocalcin, osteoprotogerin and urinary deoxypyridinoline levels (D-pyd), and bone mineral density (BMD) in 31 prepubertal boys with CDGP. These children were compared with 22 prepubertal boys with familial short stature (FSS) and 27 normal prepubertal boys. Results: Urinary D-pyd was significantly high in CDGP group as compared to control group (p=0.010). Volumetric BMD did not significantly differ between CDGP, FSS, and control groups (p=0.450). Volumetric BMD and urinary D-pyd levels of FSS and control groups were similar. Mean or median levels of calcium, phosphorus, alkaline phosphatase, parathormone, and osteoprotegerin did not significantly differ between CDGP, FSS, and control groups. Conclusions: Our data suggest that prepubertal boys with CDPG have normal bone turnover. However, their significantly higher urinary D-pyd levels relative to those of FSS and control groups might be an indicator of later development of osteoporosis. Therefore, long-term follow-up studies monitoring bone mineral status of prepubertal boys with CDPG from prepuberty to adulthood are needed to better understand bone metabolism of these patients.
Men’s hopes, fears and challenges in engagement in perinatal health and the prevention of mother-to-child transmission of HIV in rural Kenya

Abstract Male involvement in antenatal care has been shown to improve health outcomes for women and infants. However, little is known about how best to encourage male partners to support essential perinatal health activities. We explored men’s perceptions of facilitators and barriers to involvement in antenatal care and HIV prevention including fears, hopes and challenges. Forty in-depth interviews were conducted with the male partners of HIV-positive and HIV-negative pregnant women in southwest Kenya. Most male partners believed engaging in pregnancy health-related activities was beneficial for keeping families healthy. However, thematic analysis revealed several obstacles that hindered participation. Poor couple relationship dynamics seemed negatively to influence male engagement. Some men were apprehensive that clinic staff might force them to test for HIV and disclose the results; if HIV-positive, men feared being labelled as ‘victimisers’ in situations of serodiscordancy, and described fears of abandonment by their wives. Some men avoided accompanying their wives, citing local culture as rationale for avoiding the ‘effeminate’ act of antenatal care attendance. Amidst these obstacles, some men chose to use their partners’ HIV status as proxy for their own. Findings suggest that improving male engagement in essential maternal and child health-related activities will require addressing both structural and interpersonal barriers.
Serum 25‐hydroxyvitamin D concentrations in Mid‐adulthood and Parkinson's disease risk

Low vitamin D levels are common among patients with Parkinson's disease (PD). Experimental evidence further suggests that vitamin D may be protective against PD. The objective of this study was to prospectively assess the association between serum 25‐hydroxyvitamin D and PD among 12,762 participants of the Atherosclerosis Risk in Communities Study cohort.
Analysis of sensitive skin barrier function: basic indicators and sebum composition

Sensitive skin (SS) is a condition characterised by high reactivity, low tolerance, and susceptibility to allergies of the skin. Owing to changes in the environment and marketing strategies, as well as the increasing public awareness about skin care, attention to skin condition is gradually increasing. The aim of this study is to explore the differences in the skin barrier of SS and normal skin (NS).
Environmental filtering and phylogenetic clustering correlate with the distribution patterns of cryptic protist species.

The community composition of any group of organisms should theoretically be determined by a combination of assembly processes including resource partitioning, competition, environmental filtering, and phylogenetic legacy. Environmental DNA studies have revealed a huge diversity of protists in all environments, raising questions about the ecological significance of such diversity and the degree to which they obey to the same rules as macroscopic organisms. The fast-growing cultivable protist species on which hypotheses are usually experimentally tested represent only a minority of the protist diversity. Addressing these questions for the lesser known majority can only be inferred through observational studies. We conducted an environmental DNA survey of the genus Nebela, a group of closely related testate (shelled) amoeba species, in different habitats within Sphagnum-dominated peatlands. Identification based on the mitochondrial cytochrome c oxidase 1 gene, allowed species-level resolution as well as phylogenetic reconstruction. Community composition varied strongly across habitats and associated environmental gradients. Species showed little overlap in their realized niche, suggesting resource partitioning, and a strong influence of environmental filtering driving community composition. Furthermore, phylogenetic clustering was observed in the most nitrogen-poor samples, supporting phylogenetic inheritance of adaptations in the group of N. guttata. This study showed that the studied free-living unicellular eukaryotes follow to community assembly rules similar to those known to determine plant and animal communities; the same may be true for much of the huge functional and taxonomic diversity of protists.
Controlling of glutamate release by neuregulin3 via inhibiting the assembly of the SNARE complex

Significance Neuregulin3 (NRG3) is a growth factor of the neuregulin (NRG) family and a risk gene of various severe mental illnesses. However, the physiological function of NRG3 remains poorly understood. We showed that, unlike the prototype Nrg1, the effect of which is mediated by activating ErbB4 in interneurons, Nrg3 acts in a cell-autonomous manner in pyramidal neurons. By using a combination of genetic, electrophysiological, biochemical, and molecular biological techniques, we uncovered a function of Nrg3—to regulate glutamate release—and identified Nrg3 as a regulator of the assembly of the SNARE complex. We demonstrate that increasing Nrg3 expression, mimicking higher levels in mental illness patients, impairs glutamate release, revealing a pathophysiological mechanism of hypofunction of glutamatergic function. Neuregulin3 (NRG3) is a growth factor of the neuregulin (NRG) family and a risk gene of various severe mental illnesses including schizophrenia, bipolar disorders, and major depression. However, the physiological function of NRG3 remains poorly understood. Here we show that loss of Nrg3 in GFAP-Nrg3f/f mice increased glutamatergic transmission, but had no effect on GABAergic transmission. These phenotypes were observed in Nex-Nrg3f/f mice, where Nrg3 was specifically knocked out in pyramidal neurons, indicating that Nrg3 regulates glutamatergic transmission by a cell-autonomous mechanism. Consequently, in the absence of Nrg3 in pyramidal neurons, mutant mice displayed various behavioral deficits related to mental illnesses. We show that the Nrg3 mutation decreased paired-pulse facilitation, increased decay of NMDAR currents when treated with MK801, and increased minimal stimulation-elicited response, providing evidence that the Nrg3 mutation increases glutamate release probability. Notably, Nrg3 is a presynaptic protein that regulates the SNARE-complex assembly. Finally, increased Nrg3 levels, as observed in patients with severe mental illnesses, suppressed glutamatergic transmission. Together, these observations indicate that, unlike the prototype Nrg1, the effect of which is mediated by activating ErbB4 in interneurons, Nrg3 is critical in controlling glutamatergic transmission by regulating the SNARE complex at the presynaptic terminals, identifying a function of Nrg3 and revealing a pathophysiological mechanism for hypofunction of the glutamatergic pathway in Nrg3-related severe mental illnesses.
Optimizing Screening for Sexually Transmitted Infections in Men Using Self-Collected Swabs — A Systematic Review

Background Sexually transmitted infection (STI) rates are increasing in the United States while funding for prevention and treatment programs has declined. Sample self-collection for STI testing in men may provide an acceptable, easy, rapid, and potentially cost-effective method for increasing diagnosis and treatment of STIs. Methods We conducted a systematic review of articles assessing self-collection of anal, oral, or genital swab samples among adult men for detection of STIs and/or human papillomavirus–related dysplasia. We searched for English-language articles in which men 18 years or older were recruited to participate. Results Our literature search resulted in 1053 citations, with 20 meeting inclusion criteria. Self-collection methods were highly sensitive and comparable with clinician collection for detection of multiple STI pathogens. However, self-collected samples were less likely to be of adequate quality for anorectal cytology and less sensitive for detection of anal intraepithelial neoplasia than clinician-collected samples. Self-collection was highly acceptable. Overall, studies were small and heterogeneous and used designs providing lower levels of evidence. Conclusions Self-collection methods are a viable option for collecting samples for STI testing in adult men based on their high feasibility, acceptability, and validity. Implementation of self-collection procedures in STI testing venues should be performed to expand opportunities for STI detection and treatment.