Miracle-dz/UniFAR-FTUs huggingface dataset:
Transforming core emotional pain in a course of emotion-focused therapy for depression: A case study

Abstract Objective: To investigate the pattern of change in emotional states over a course of emotion-focused therapy using the model of sequential emotional processing as an initial framework for analysis. Method: This was a single case study observational design examining 15 sessions of therapy with one client. A qualitative analysis of moment-to-moment shifts in client emotional events was conducted. This conceptualised the interplay between experienced emotions using the sequential emotional processing model as an interpretative framework. The analysis was triangulated by using existing observer-based rating scales and reliability assessed with an independent rater. Results: The sequential emotional processing model was found to be an effective means to explain the sequence of expressed emotional events, although some emotional events and emotion scheme change processes pertaining to this particular case required additional explanation than provided in the original model descriptions. Conclusions: Observed nuances in this specific case included highlighting triggers to emotional experience and avoidance processes fuelled by anticipatory fear. The observations included a process of change through accessing core feelings of shame, fear, and loneliness and their transformation through the generation of self-compassion and assertive anger. Implications for practice are discussed in terms of case conceptualisation and therapeutic strategy.
Mechanical crimp texturizing of non-thermoplastic viscose rayon yarn

There are technological limitations in the processing of smooth, slippery and rather flat multifilament viscose rayon yarn. The present work describes a shorter route for viscose rayon modification through mechanical crimp texturizing. Texturizing was performed with different pre-twists and optimized texturizing twist. This work describes a shorter and cost effective route for viscose rayon modification through mechanical crimp texturizing. The prepared texturized viscose rayon yarn has achieved the desirable structural characteristics of spun yarn as depicted in SEM micrographs. The textured yarn has retained an almost identical fineness with the parent yarn. Unlike air jet texturizing, mechanical crimp texturizing has benefits in terms of retro-processing of costlier viscose rayon yarn. Although it was textured, it has not shown any significant drop in tenacity and, apart from that, shows enhanced the elongation property compared to the parent yarn.
Prediction of protein subcellular locations by support vector machines using compositions of amino acids and amino acid pairs

MOTIVATION The subcellular location of a protein is closely correlated to its function. Thus, computational prediction of subcellular locations from the amino acid sequence information would help annotation and functional prediction of protein coding genes in complete genomes. We have developed a method based on support vector machines (SVMs). RESULTS We considered 12 subcellular locations in eukaryotic cells: chloroplast, cytoplasm, cytoskeleton, endoplasmic reticulum, extracellular medium, Golgi apparatus, lysosome, mitochondrion, nucleus, peroxisome, plasma membrane, and vacuole. We constructed a data set of proteins with known locations from the SWISS-PROT database. A set of SVMs was trained to predict the subcellular location of a given protein based on its amino acid, amino acid pair, and gapped amino acid pair compositions. The predictors based on these different compositions were then combined using a voting scheme. Results obtained through 5-fold cross-validation tests showed an improvement in prediction accuracy over the algorithm based on the amino acid composition only. This prediction method is available via the Internet.
Impacts of dietary calcium, phytate, and phytase on inositol hexakisphosphate degradation and inositol phosphate release in different segments of digestive tract of broilers

&NA; A total of 720 straight‐run Heritage 56 M × fast feathering Cobb 500F broiler chickens was fed from 11 to 13 d of age to determine the impacts of dietary calcium (Ca), phytate phosphorus (PP), and phytase concentrations on inositol phosphate (IP3‐6) profile in different digestive tract (GI) segments. The experiment was a 2 × 2 × 3 randomized block design with 2 Ca (0.7 and 1.0%) and 2 PP (0.23 and 0.34%) concentrations and 3 doses of Buttiauxella sp. phytase (0, 500, and 1,000 FTU/kg). The experiment was replicated in time (block) with 3 replicates per treatment (Trt) of 10 birds per block. Concentrations of IP3‐6 in the crop, proventriculus (Prov) plus (+) gizzard (Giz), and distal ileum, as well as the ileal IP6 and P disappearance were determined at 13 d of age. The detrimental impact of Ca on IP6 and P disappearance was observed only in the ileum, where 11% reduction in both IP6 and P disappearance was seen when Ca increased from 0.7 to 1.0% (P < 0.05). Higher IP5 and IP6 concentrations were seen in both the crop and Prov+Giz at 0.34% PP as compared to birds fed to 0.23% PP diets, regardless of Ca or phytase (P < 0.05), whereas IP3 and IP4 concentrations were not affected by PP (P > 0.05). Inclusion of phytase, at both 500 and 1,000 FTU/kg, resulted in lower IP6 and the accumulation of lower IP ester (IP3‐5) concentrations in all GI segments (P < 0.05). Improved IP6 and P disappearance was seen as a result of phytase inclusion, despite the degree of improvement affected by PP (P < 0.05). On average, 5.5 and 6.7 times improvement in IP6 was observed with 500 and 1,000 FTU phytase/kg inclusion, respectively, resulting in 41 and 64% greater P digestibility, respectively. In conclusion, phytase can effectively degrade IP6 to lower esters and increase P utilization. However, the efficacy of phytase can be affected by diet Ca and PP concentrations.
A review of glucosamine for knee osteoarthritis: why patented crystalline glucosamine sulfate should be differentiated from other glucosamines to maximize clinical outcomes

Abstract The European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) treatment algorithm for knee osteoarthritis (OA) recommends symptomatic slow-acting drugs for osteoarthritis (SYSADOAs) first line for the medium to long term management of OA, due to their ability to control pain, improve function, and delay joint structural changes. Among SYSADOAs, glucosamine is probably the most widely used intervention. In the present review of glucosamine for knee OA, we have investigated whether the evidence is greater for the patented crystalline glucosamine sulfate (pCGS) preparation (Rottapharm/Meda) than for other glucosamine formulations. Glucosamine is actually widely available in many forms, as the prescription-grade pCGS preparation, generic and over-the-counter formulations of glucosamine sulfate (GS) and food supplements containing glucosamine hydrochloride (GH), which vary substantially in molecular form, pharmaceutical formulation and dose regimens. Only pCGS is given as a highly bioavailable once daily dose (1500 mg) with a proven pharmacological effect. pCGS consistently reaches the plasma levels of around 10 μM required to inhibit interleukin-1 induced expression of genes involved in the pathophysiology of joint inflammation and tissue destruction, compared with sub-therapeutic levels achieved with GH. It is evident, from careful consideration of the evidence base, that only the pCGS formulation of glucosamine reliably provides an effect size on pain that is higher than that of paracetamol and equivalent to that provided by non-steroidal anti-inflammatory drugs. In comparison, the effect size on pain of non-crystalline GS preparations and GH from randomized controlled trials is repeatedly demonstrated to be zero. In addition, there is evidence that chronic administration of pCGS has disease-modifying effects, with a reduction in the need for total joint replacement surgery lasting for at least 5 years after treatment cessation. Consequently, the pCGS preparation (Rottapharm/Meda) is the logical choice, with demonstrated medium-term control of pain and lasting impact on disease progression.
Single or Multiple? Combining Word Representations Independently Learned from Text and WordNet

Text and Knowledge Bases are complementary sources of information. Given the success of distributed word representations learned from text, several techniques to infuse additional information from sources like WordNet into word representations have been proposed. In this paper, we follow an alternative route. We learn word representations from text and WordNet independently, and then explore simple and sophisticated methods to combine them. The combined representations are applied to an extensive set of datasets on word similarity and relatedness. Simple combination methods happen to perform better that more complex methods like CCA or retrofitting, showing that, in the case of WordNet, learning word representations separately is preferable to learning one single representation space or adding WordNet information directly. A key factor, which we illustrate with examples, is that the WordNet-based representations captures similarity relations encoded in WordNet better than retrofitting. In addition, we show that the average of the similarities from six word representations yields results beyond the state-of-the-art in several datasets, reinforcing the opportunities to explore further combination techniques.
Assessment of Renal and Hepatic Tissue-Protective Effects of N-Acetylcysteine via Ammonia Metabolism: A Prospective Randomized Study

BACKGROUND The present study sought to assess the renal and liver protective effect of N-acetylcysteine through NH3 and urea metabolism in patients with chronic obstructive pulmonary disease who were scheduled for coronary artery bypass grafting surgery. MATERIAL AND METHODS Patients with chronic obstructive pulmonary disease (COPD) who were scheduled for coronary artery bypass grafting were divided into 2 groups so as to receive (Group 1, n=35) or not receive (Group 2, n=35) 900 mg/day of n-acetylcysteine for 7 days before the operation starting from their admission to the service by a pulmonologist with the purpose of treating COPD until the day of surgery. Both groups were subjected to the same anesthesia protocol. Blood samples were taken preoperatively, within the first 15th minute following cessation of the cardiopulmonary bypass, at postoperative 24th hour, and at postoperative 48th hour. Blood tests included ammonia (NH3), lactate, blood urea nitrogen, creatinine, aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), troponin I (Tn I), and creatinine kinase-muscle brain (CKMB). RESULTS There was a significant difference between the groups' NH3 and lactate levels after cardiopulmonary bypass, postoperative 24th hour, and postoperative 48th hour (respectively, NH3: 39.0±8.8 vs. 55.4±19.6 and 40.1±8.4 vs. 53.2±20.2 mcg/dl, lactate: 1.7±0.9 vs. 2.1±1.2 and 1.2±0.5 vs. 1.8±1.4 mmol/L; p<0.01). Creatinine and BUN levels in Group 2 were found to be significantly higher at the postoperative 48th hour compared to the levels of Group 1 (P<0.05). CONCLUSIONS N-acetylcysteine pretreatment appears to improve renal and hepatic functions through regulation of ammonia and nitrogen metabolism and reduction of lactate in patients with chronic obstructive pulmonary disease who undergo coronary artery bypass grafting surgery. We found that N-acetylcysteine improved kidney and/or liver functions.
Development of wide band gap materials for thin film silicon solar cells

In the frame of this work, wide band gap materials, in particular amorphous and microcrystalline silicon-oxide (SiO) and -carbide (SiC) layers, prepared by 13.56 MHz PECVD, were developed for application in thin film silicon solar cells. By means of optical, electrical and structural material characterizations combined with plasma diagnostics, the influence of the deposition parameters on the film growth were investigated. For microcrystalline silicon oxide (μc-SiOx:H), it was found that with increasing deposition power, the crystallinity does not correlate with enhanced precursor dissociation as typical for pure microcrytalline silicon (μc-Si:H). Contrarily, it decreases significantly due to the higher observed oxygen incorporation. The crystallinity can be recovered by increasing the deposition pressure in the studied regime. This can be explained by reduced ion bombardment and/or increased silan depletion. The films were successfully applied as intermediate reflectors layer (IRL) in a-Si:H/μc-Si:H tandem solar cells. The deposition of a thin μc-Si:H n-layer behind the IRL was found to significantly improved the tunnel recombination junction resulting in a lower series resistance. The effect could be simulated using semi conductor theory. The effectiveness of the IRL in regard of the TCO substrate was investigated. Large differences regarding the effectiveness and the ideal thickness of the IRL were observed. Rigorous optical 2D simulations indicate that a low autocorrelation length of the TCO topography in the range of 100-300 nm increases the effectiveness significantly. SiC layers were deposited in a similar regime to the μc-SiOx:H layers. Although no crystallinity was achieved, the presented approach can be a basis for further experiments. The electron beam crystallization of near stoichiometric layers showed first indications of a crystalline SiC phase.
Discovery of Novel Bovine Viral Diarrhea Inhibitors Using Structure-Based Virtual Screening on the Envelope Protein E2

Bovine viral diarrhea virus (BVDV) is a member of the genus Pestivirus within the family Flaviviridae. BVDV causes both acute and persistent infections in cattle, leading to substantial financial losses to the livestock industry each year. The global prevalence of persistent BVDV infection and the lack of a highly effective antiviral therapy have spurred intensive efforts to discover and develop novel anti-BVDV therapies in the pharmaceutical industry. Antiviral targeting of virus envelope proteins is an effective strategy for therapeutic intervention of viral infections. We performed prospective small-molecule high-throughput docking to identify molecules that likely bind to the region delimited by domains I and II of the envelope protein E2 of BVDV. Several structurally different compounds were purchased or synthesized, and assayed for antiviral activity against BVDV. Five of the selected compounds were active displaying IC50 values in the low- to mid-micromolar range. For these compounds, their possible binding determinants were characterized by molecular dynamics simulations. A common pattern of interactions between active molecules and aminoacid residues in the binding site in E2 was observed. These findings could offer a better understanding of the interaction of BVDV E2 with these inhibitors, as well as benefit the discovery of novel and more potent BVDV antivirals.
Direct Observation of Field Emission Sites in a Single Multiwalled Carbon Nanotube by Lorenz Microscopy

Emission sites were observed as bright spots near the tip end of a multiwalled carbon nanotube (MWNT) by means of Lorenz microscopy. The bright spots appeared above electric fields as electrons were emitted. A marked fluctuation was observed in the emission current above 20–30 µA, which was closely related to structural changes at the tip of the MWNT. The layers of the MWNT were peeled off during field emission and they functioned as the second emission sites for the concentration of electric field.
Differences in Teaching Self-Determination between General and Special Education Teachers in Elementary Schools

The purpose of this study was to investigate whether there are differences in the teaching of self-determination between general and special education teachers in Taiwan. The participants were 380 teachers recruited from elementary schools nationwide in Taiwan. Among them, 128 were general education teachers, while the others were special educators providing services in either resource rooms ( n = 125) or self-contained classrooms ( n = 127). The Teaching Self-Determination Scale (TSDS) was used to collect data. Descriptive statistics, t tests, analyses of variance (ANOVAs) and multivariate analyses of variance (MANOVAs) were employed to analyze data. Findings showed that both general and special education teachers’ level of teaching self-determination was in the range of “ sometimes to often ”. Nevertheless, general education teachers’ level in teaching psychological empowerment, self-regulation, and autonomous skills was higher than that of their special education counterparts. Additionally, general educators tended to focus the most on instructing psychological empowerment abilities, while the self-contained classroom teachers paid intense attention to the teaching of autonomous skills. Resource room teachers demonstrated a relatively balanced instruction of various skills. Findings of this study enabled us to further understand elementary school teachers’ level of teaching self-determination and its characteristics as well. Suggestion and implications are provided.
Chronic high glucose and insulin stimulate bone‐marrow stromal cells adipogenic differentiation in young spontaneously hypertensive rats

We evaluated whether genetic predisposition is sufficient to induce changes due to chronic high glucose (HG; 25 mmol/L) in the presence or absence of insulin (HGI; 10 μg/ml) on osteogenic differentiation and markers in bone‐marrow mesenchymal stem cells (BMSCs) from young Wistar (WBMSCs) and spontaneous hypertensive rats (SBMSCs) without hypertension. HG suppressed osteogenic differentiation in both the strains, observed by mineralization inhibition and decreased levels of the osteogenic markers Runx2, osterix, osteopontin, and bone sialoprotein, compared to osteogenic medium (OM) cells. In WBMSCs, the effects of HG were associated with the down regulation of ERK1/2 and up regulation of p38 activities; however, HGI did not revert the effects of HG on MAPK activities. Moreover, HG did not affect MAPK signaling in SBMSCs compared to that in OM. HGI increased mineralization in WBMSCs compared to that in OM, but not in SBMSCs. High expression of peroxisome proliferator‐activated receptor‐gamma and glucose transporter type 4 in OM could be related with the predisposition to adipogenic differentiation noted in SBMSCs and was confirmed by emergence of adipocyte‐like cells by HGI treatment. Downregulation of p38 and upregulation of JNK activities were observed in both BMSCs treated with HGI compared to those treated by HG. Ma (osmotic control) also suppressed osteogenic differentiation in both the strains. In conclusion, we demonstrated that SBMSCs from young spontaneous hypertensive rats, without hypertension but with genetic and epigenetic predisposition, exhibited decreased osteoblastic differentiation under HG and HGI did not revert the effects of HG in SBMSCs but increased adipogenic differentiation.
Association of Flooring Materials with Milk Yield and its Composition in Crossbred cows

Present study was conducted to evaluate the effect of concrete or rubber surface, in combination with open yard with either brick paving or sand bed on milk production and composition in crossbred dairy cows under loose housing system. Total 20 crossbred cows, were assigned to four treatment groups (5 per group) viz. Control group (T0): Concrete floor (in covered feeding area) + Brick paving (in loafing area); Treatment 1 (T1): Concrete floor + Sand bed; Treatment 2 (T2): Rubber mat + Sand bed; Treatment 3 (T3): Rubber mat + Brick paving. Milk yield did not differed significantly (P>0.05) among groups, but it was higher in T2 followed by T3, T0 (control) and T1. Fat %, SNF % and Total Solids % were almost similar (P > 0.05) in all the groups. Therefore, it can be concluded that provision of rubber mat or sand floor alone does not affect milk production and composition. However, floor combination of rubber mat and sand bed in loose houses showed higher production.
Mechanical Characterization of Si3N4-BN(pl) Composites

The solid lubrication properties of BN led to the development of Si3N4BN composites, aiming the production of self-lubricated high performance materials. Composites containing 10, 18 and 25vol% of hexagonal BN were hot-pressed at 1650°C, 25MPa. The microstructure was characterized by SEM, X-ray diffraction and stereologic image analysis. Vickers indentations were performed to evaluate hardness and indentation fracture toughness. The hardness ranged from HV=12.9GPa to HV=2.1GPa with increasing BN amount. For a given amount of BN, hardness is higher in the surfaces parallel to the hot-pressing direction, as the basal planes of the BN platelets tend to align perpendicularly to this direction. The anisotropy in the microstructure also affects the values of KIc, since the cracks deflect, aligning themselves with the platelets, or, in some cases, they cannot even propagate. When the propagation direction of the cracks is not perpendicular to the basal planes of the platelets, the fracture toughness does not change significantly with the amount or orientation of BN, having values between KIc=3.5MPa. m 1/2 and KIc=5.9MPa. m 1/2 .
Characteristic S-N Property of High Carbon Chromium Bearing Steel under Axial Loading in Long Life Fatigue

Fatigue properties of a bearing steel (SUJ 2) including long life region were experimentally examined under axial loading and discussed from viewpoints of fractography and fracture mechanics. Thus, the complicated S-N property in the wide life region was well explained as the duplex S-N characteristics superimposed two different S-N curves for surface induced fracture and interior inclusion induced fracture. Fish-eye was formed on the fracture surface of each specimen in the interior inclusion induced fracture. Fine granular area (FGA) was necessarily observed around the inclusion at the center of the fish-eye. Stress intensity factor ranges at FGA, fish-eye and final fracture stage were in good agreement with their corresponding levels in the crack propagation law confirmed by CT specimens.
Psychiatric Priorities in Developing Countries

Summary Many psychiatrists assert that an expansion of mental health services in the developing countries is overdue. This will only take place if: (i) the tasks of mental health care are undertaken by a wide range of non-specialist health workers, including those responsible for primary health care; and (ii) services are directed initially at a very limited range of priority conditions. The method of priority selection is discussed, and the process required for translation of priority decisions into health action is exemplified by two illustrations.