Miracle-dz/UniFAR-FTUs huggingface dataset:
Electronic Brainstorming: The Illusion of Productivity

Electronic brainstorming (EBS) has been proposed as a superior approach to both nominal brainstorming (working alone) and face-to-face brainstorming (verbal). However, existing empirical evidence regarding EBS's superiority over nominal brainstorming is weak. Through a comprehensive examination of the process gains and process losses inherent to different brainstorming approaches, this paper explains past results. The paper also suggests that the process gain versus process loss advantages of EBS technologies may not be large enough to enable EBS groups to outperform nominal groups. In an effort to find alternate ways of using EBS more productively, three conditions thought to increase EBS's process gains and decrease its process losses (thus improving its productivity) are identified. A laboratory experiment designed to compare the productivity of ad hoc and established groups using four brainstorming technologies (nominal, EBS-anonymous, EBS-nonanonymous, verbal), generating ideas on socially sensitive and less sensitive topics, in the presence and absence of contextual cues, is then described. The results of the experiment showed that overall, groups using nominal brainstorming significantly outperformed groups using the other three brainstorming approaches. Further, even under conditions thought to be favorable to EBS, nominal brainstorming groups were at least as productive as EBS groups. The paper explains these results by suggesting that the process gains of EBS may not be as large as expected and that the presence of four additional process losses inherent to EBS technologies impair its productivity. It is also argued that the prevailing popularity of group brainstorming (verbal or electronic) in organizations may be explained by the perceived productivity of those approaches. These perceptions, which are at odds with reality, create the illusion of productivity. A similar misperception may also cause an illusion of EBS productivity in the research community, especially when perceptual measures of group performance are used.
Race, Ethnicity, Psychosocial Factors, and Telomere Length in a Multicenter Setting

Background Leukocyte telomere length(LTL) has been associated with age, self-reported race/ethnicity, gender, education, and psychosocial factors, including perceived stress, and depression. However, inconsistencies in associations of LTL with disease and other phenotypes exist across studies. Population characteristics, including race/ethnicity, laboratory methods, and statistical approaches in LTL have not been comprehensively studied and could explain inconsistent LTL associations. Methods LTL was measured using Southern Blot in 1510 participants from a multi-ethnic, multi-center study combining data from 3 centers with different population characteristics and laboratory processing methods. Main associations between LTL and psychosocial factors and LTL and race/ethnicity were evaluated and then compared across generalized estimating equations(GEE) and linear regression models. Statistical models were adjusted for factors typically associated with LTL(age, gender, cancer status) and also accounted for factors related to center differences, including laboratory methods(i.e., DNA extraction). Associations between LTL and psychosocial factors were also evaluated within race/ethnicity subgroups (Non-hispanic Whites, African Americans, and Hispanics). Results Beyond adjustment for age, gender, and cancer status, additional adjustments for DNA extraction and clustering by center were needed given their effects on LTL measurements. In adjusted GEE models, longer LTL was associated with African American race (Beta(β)(standard error(SE)) = 0.09(0.04), p-value = 0.04) and Hispanic ethnicity (β(SE) = 0.06(0.01), p-value = 0.02) compared to Non-Hispanic Whites. Longer LTL was also associated with less than a high school education compared to having greater than a high school education (β(SE) = 0.06(0.02), p-value = 0.04). LTL was inversely related to perceived stress (β(SE) = -0.02(0.003), p<0.001). In subgroup analyses, there was a negative association with LTL in African Americans with a high school education versus those with greater than a high school education(β(SE) = -0.11(0.03), p-value<0.001). Conclusions Laboratory methods and population characteristics that differ by center can influence telomere length associations in multicenter settings, but these effects could be addressed through statistical adjustments. Proper evaluation of potential sources of bias can allow for combined multicenter analyses and may resolve some inconsistencies in reporting of LTL associations. Further, biologic effects on LTL may differ under certain psychosocial and racial/ethnic circumstances and could impact future health disparity studies.
IL-10 Paradoxically Promotes Autoimmune Neuropathy through S1PR1-Dependent CD4+ T Cell Migration

Chronic inflammatory demyelinating polyneuropathy (CIDP) is a debilitating condition caused by autoimmune demyelination of peripheral nerves. CIDP is associated with increased IL-10, a cytokine with well-described anti-inflammatory effects. However, the role of IL-10 in CIDP is unclear. In this study, we demonstrate that IL-10 paradoxically exacerbates autoimmunity against peripheral nerves. In IL-10–deficient mice, protection from neuropathy was associated with an accrual of highly activated CD4+ T cells in draining lymph nodes and absence of infiltrating immune cells in peripheral nerves. Accumulated CD4+ T cells in draining lymph nodes of IL-10–deficient mice expressed lower sphingosine-1-phosphate receptor 1 (S1pr1), a protein important in lymphocyte egress. Additionally, IL-10 stimulation in vitro induced S1pr1 expression in lymph node cells in a STAT3-dependent manner. Together, these results delineate a novel mechanism in which IL-10–induced STAT3 increases S1pr1 expression and CD4+ T cell migration to accelerate T cell–mediated destruction of peripheral nerves.
Layout-dependent aging mitigation for critical path timing

Layout-dependent effects (LDEs) are becoming increasingly important as technology node continues to shrink into the regime of FinFET transistors. Prior LDE studies mainly focus on accurate transistor modeling and fast circuit performance evaluations at the early lifetime of a design. Few studies have been performed on the layout dependency of the circuit aging towards the end of life (EOL). This study demonstrates that, due to transistor-level layout-dependent aging (LDA) behaviors, circuit-level timing degradations are greatly impacted by layout configurations, including length of diffusion and oxide spacing. In this paper, we propose the first circuit-level aging mitigation framework to improve the critical-path timing towards the EOL. Our framework features comprehensive LDA evaluations for standard cell timing, which shows that multiple-row height cells lead to worse EOL timing than singlerow height cells due to length-of-diffusion effects. We further propose a min-cost-flow-based placement approach to concurrently allocate the oxide spacing among neighboring standard cells, which generates much better EOL timing than a conventional greedy approach. Experimental results demonstrate that under the concurrent approach in the proposed aging mitigation framework, the total and worst negative slacks for EOL timing are on average reduced by 42% and 25%, respectively.
The effect of gender on patients with moderate to severe head injuries.

BACKGROUND Male and female nervous systems respond differently to traumatic brain injury (TBI) and in vivo research relates this difference to neuroprotection from female sex hormones. Attempts to replicate female sex hormone-related neuroprotection in clinical studies have been unsuccessful. The objective of this study was to determine whether gender or menopausal status affects mortality in patients with moderate to severe TBI. METHODS A retrospective review of all patients with isolated moderate to severe TBI was undertaken using data from the National Trauma Database version 6.2 (2000-2005). Isolated TBI was defined as head Abbreviated Injury Score >/=3 in patients without significant extracranial injuries (Abbreviated Injury Score <3 for other anatomic regions). Demographics, Injury Severity Score, and outcomes (mortality, intensive care unit and hospital length of stay, and complications) were compared. The population was stratified into age subgroups: 14 to 45 years (premenopausal), 46 to 55 years (perimenopausal), and older than 55 years (postmenopausal). Logistic regression analysis was used to determine the relationship among female gender, mortality, and development of complications after moderate to severe TBI. RESULTS A total of 72,294 patients with moderate to severe TBI were evaluated. Females showed a significantly lower risk in both mortality (adjusted odds ratios [AOR], 0.82; 95% confidence intervals [CI], 0.77-0.87; p < 0.0001) and in developing any type of complications (AOR, 0.88; 95% CI, 0.84-0.93; p < 0.0001) than the male population after adjusting for differences in patient characteristics. After age stratification, perimenopausal women (46-55 years) and postmenopausal women (older than 55 years) showed a significantly lower risk in mortality (AOR, 0.76; 95% CI, 0.63-0.92; p < 0.0044 and AOR, 0.79; 95% CI, 0.73-0.86; p < 0.0001, respectively). There was no difference in mortality in premenopausal women compared with their male age-matched counterparts (AOR, 1.09; 95% CI, 0.99-1.21; p = 0.0917). CONCLUSIONS Female gender is independently associated with reduced mortality and decreased complications after TBI. As peri- and postmenopausal women demonstrated improved survival, and premenopausal women did not, estrogen unlikely confers neuroprotection in women after TBI. Future TBI treatment may benefit with further research focused on why peri- and postmenopausal women show decreased mortality after TBI.
Induced Microearthquake Patterns in Hydrocarbon and Geothermal Reservoirs : A Review

The injection or production of fluids can induce microseismic events in hydrocarbon and geothermal reservoirs. By deploying sensors downhole, data sets have been collected that consist of a few hundred to well over 10,000 induced events. We find that most induced events cluster into well-defined geometrical patterns. In many cases, we must apply high-precision, relative location techniques to observe these patterns. At three sedimentary sites, thin horizontal strands of activity are commonly found within the location patterns. We believe this reflects fracture containment between stratigraphic layers of differing mechanical properties or states of stress. At a massive carbonate and two crystalline sites, combinations of linear and planar features indicate networks of intersecting fractures and allow us to infer positions of aseismic fractures through their influence on the location patterns. In addition, the fine-scale seismicity patterns often evolve systematically with time. At sedimentary sites, migration of seismicity toward the injection point has been observed and may result from slip-induced stress along fractures that initially have little resolved shear. In such cases, triggering events may be critical to generate high levels of seismic activity. At one crystalline site, the early occurrence of linear features that traverse planes of activity indicate permeable zones and possible flow paths within fractures. We hope the continued development of microseismic techniques and refinement of conceptual models will further increase our understanding of fluid behavior and lead to improved resource management in fractured reservoirs.
Nonsuicidal Self‐Injury in Adolescents: Characterization of the Disorder and the Issue of Distress and Impairment

Nonsuicidal self-injury disorder (NSSID) is a condition in need of further study to assess the validity of the potential diagnosis and its suggested criteria. This study examined the NSSID diagnosis and investigated the distress/impairment criterion by comparing community adolescents who met all criteria for NSSID (n = 186) to adolescents with five or more nonsuicidal self-injury (NSSI) episodes (n = 314), and to a group of adolescents who met all criteria but negated that their NSSI caused them any distress or impairment, thus failing to meet criterion E (n = 29). The NSSID group delimited from the ≥ 5 NSSI group by reporting significantly more frequent and severe self-injurious thoughts and behaviors, as well as having more experiences of negative life events and higher levels of trauma symptoms. There were also some differences between the NSSID group and adolescents without distress/impairment, which together contribute valuable information on the potential NSSID diagnosis, as well as the discussion of criterion E.
Gender differences in the acceptance of information and communication technologies: the case of internet usage

Information and Communication Technologies (ICTs) are not evenly accessible for all the individuals in different regions or countries. Several factors including income, education, literacy levels, race, ethnicity and gender influence this disparity. The gender digital divide is still present in both the developed and developing countries. The generally negative perceptions of women regarding the utilisation of ICTs prevent them from participating and benefitting in the new information society. The aim of this study is to investigate the effects of gender difference on internet users' beliefs and usage behaviours. The results revealed that men's assessments of ease of use, usage enjoyment and Behavioural Control (BC) were higher than that of women's. The findings of this study suggest that researchers and practitioners should take into consideration gender differences during the development, validation, implementation and control stages of internet acceptance theories, e-commerce practices and distance education alternatives.
HSP70‐hom gene polymorphisms modify the association of diethylhexyl phthalates with insulin resistance

Recent studies suggest that diethylhexyl phthalates (DEHP) could contribute to the development of insulin resistance (IR) through oxidative stress, and that heat shock protein (HSP) could be related with the association between DEHP and IR. Therefore, we evaluated the effect modification of genetic polymorphisms of HSP70‐hom, an oxidative stress related gene, on the relation between exposure to DEHP and IR. We obtained repeated blood and urine samples from 414 elderly female participants and measured urinary levels of mono‐(2‐ethyl‐5‐hydroxyhexyl) phthalate (MEHHP) and mono‐(2‐ethyl‐5‐oxohexyl) phthalate (MEOHP) as metabolites of DEHP. We also measured serum levels of fasting glucose and insulin, derived the homeostatic model assessment (HOMA) index to assess IR, and genotyped two HSP70‐hom polymorphisms (rs2227956 and rs2075800). A mixed effect model and penalized regression spline were used to estimate the associations between DEHP exposure and IR by genetic polymorphisms. The molar sum of MEHHP and MEOHP (∑DEHP) were significantly associated with HOMA (β = 0.30, P = 0.022). When stratified by genotype at rs2227956, the relationship between ∑DEHP and HOMA was statistically significant in participants with TT (β = 0.32, P = 0.048) or TC (β = 0.60, P = 0.008), while at rs2075800 there was a marginal association for the GA genotype (β = 0.33, P = 0.097). When haplotypes were constituted across the two HSP70‐hom polymorphisms (rs2227956 and rs2075800), the association was apparent only in participants with the T‐A haplotype (β = 0.39, P = 0.029). Our study suggests that HSP70‐hom polymorphisms modify the association of DEHP with IR. Environ. Mol. Mutagen. 55:727–734, 2014. © 2014 Wiley Periodicals, Inc.
Meta-analysis of aspirin use and risk of lung cancer shows notable results

Aspirin is a promising agent for chemoprevention of lung cancer. We assessed the association of aspirin use and the development of lung cancer, with a focus on heterogeneity between studies. Databases were searched for relevant studies until September 2014. Studies evaluating the relationship of aspirin use and incidence of lung cancer were considered. Relative risks (RR) were extracted and a pooled estimate was calculated. Heterogeneity was assessed by the I2 measure, random-effects models, and finite-mixture models. Sources of heterogeneity were investigated using a meta-regression. A decreased risk of lung cancer was found including 20 studies [RR=0.87, 95% confidence interval (CI): 0.79–0.95] on the basis of a random-effects model. Strong heterogeneity was observed (&tgr;2=0.0258, I2=74.4%). As a result, two subpopulations of studies were identified on the basis of a mixture model. The first subpopulation (42%) has an average RR of 0.64. The remaining subpopulation (58%) shows an RR of 1.04. Different results were found for case–control (RR=0.74, 95% CI: 0.60–0.90) and cohort studies (RR=0.99, 95% CI: 0.93–1.06) in a stratified analysis. In a subgroup analysis, use of aspirin was associated with a decreased risk of non-small-cell lung cancer in case–control studies (RR=0.74; 95% CI: 0.58–0.94). At first glance, our meta-analysis shows an average protective effect. A second glance indicates that there is strong heterogeneity. This leads to a subpopulation with considerable benefit and another subpopulation with no benefit. For further investigations, it is important to identify populations that benefit from aspirin use.
A 16.6-pJ/b 150-Mb/s body-channel communication transceiver with decision feedback equalization improving >200x area efficiency

This paper presents a body-channel communication (BCC) transceiver adopted with decision feedback equalization (DFE). The proposed transceiver, fabricated in 65-nm CMOS process, achieves reliable (BER<10−6) data rates of 150 Mb/s (16.6 pJ/b), and 100 Mb/s (23.5 pJ/b) over 20-cm and 1.3-m channels on human limbs. The transceiver occupies a total core area of 5580 qm2, which is less than 1% compared to any previously-presented work.
Faecal haemoglobin concentration influences risk prediction of interval cancers resulting from inadequate colonoscopy quality: analysis of the Taiwanese Nationwide Colorectal Cancer Screening Program

Objectives Interval colorectal cancer (CRC) after colonoscopy may affect effectiveness and cost-effectiveness of screening programmes. We aimed to investigate whether and how faecal haemoglobin concentration (FHbC) of faecal immunochemical testing (FIT) affected the risk prediction of interval cancer (IC) caused by inadequate colonoscopy quality in a FIT-based population screening programme. Design From 2004 to 2009, 29 969 subjects underwent complete colonoscopy after positive FIT in the Taiwanese Nationwide CRC Screening Program. The IC rate was traced until the end of 2012. The incidence of IC was calculated in relation to patient characteristics, endoscopy-related factors (such adenoma detection rate (ADR)) and FHbC. Poisson regression analysis was performed to assess the potential risk factors for colonoscopy IC. Results One hundred and sixty-two ICs developed after an index colonoscopy and the estimated incidence was 1.14 per 1000 person-years of observation for the entire cohort. Increased risk of IC was most remarkable in the uptake of colonoscopy in settings with ADR lower than 15% (adjusted relative risk (aRR)=3.09, 95% CI 1.55 to 6.18) and then higher FHbC (μg Hb/g faeces) (100–149: aRR=2.55, 95% CI 1.52 to 4.29, ≥150: aRR=2.74, 95% CI 1.84 to 4.09) with adjustment for older age and colorectal neoplasm detected at baseline colonoscopy. Similar findings were observed for subjects with negative index colonoscopy. Conclusions Colonoscopy ICs arising from FIT-based population screening programmes were mainly influenced by inadequate colonoscopy quality and independently predicted by FHbC that is associated with a priori chance of advanced neoplasm. This finding is helpful for future modification of screening logistics based on FHbC.
Testing of Seasonal Fractional Integration in UK and Japanese Consumption and Income

The seasonal structure of quarterly UK and Japanese consumption and income is examined by means of fractionally-based tests proposed by Robinson (1994). These series were analysed from an autoregressive unit root viewpoint by Hylleberg, Engle, Granger and Yoo (HEGY, 1990) and Hylleberg, Engle, Granger and Lee (HEGL, 1993). We find that seasonal fractional integration, with amplitudes possibly varying across frequencies, is an alternative plausible way of modelling these series.
Faulty Adaptation to Repeated Face-Name Associative Pairs in Mild Cognitive Impairment is Predictive of Cognitive Decline

Objective We examined BOLD (Blood-Oxygen-Level Dependent) activity reduction upon stimuli repetition of face-name pairs in older adults with amnestic (aMCI) and non-amnestic (naMCI) mild cognitive impairment diagnosed using a comprehensive actuarial method, and relationships between activity reduction and behavioral indices. Method Twenty-nine cognitively healthy older adults (CHs) and 20 with MCI (n = 12 aMCI; n = 8 naMCI) underwent functional MRI event-related imaging, a comprehensive neuropsychological battery, and 1-year follow-up exam. During scanning, participants were shown face-name pairs 1-3 times and administered a post-scan recognition task. Results The MCI group demonstrated less activity reduction upon repetition of face-name pairs within the MTL and other regions compared to CHs. Less activity reduction was associated with poorer Time 1 neuropsychological performance for the CH group and poorer post-scan recognition performance for the MCI group. Less activity reduction was related to poorer neuropsychological performance at Time 2 in the MCI group. Within MCIs, those with aMCI demonstrated less activity reduction upon repetition of face-name pairs than those with naMCI. Conclusions Distinct patterns of brain activity were identified in the MCI group compared to CHs, and aMCI compared to naMCI. Activated regions were not restricted to traditional memory circuitry, implicating a wider network of regions involved in the encoding of associative tasks. Findings add support to the hypothesis that lack of reduced BOLD activity reflects "faulty adaptation" to repeated stimuli and that reduction in activity represents successful encoding processes. They also provide further support for use of the face-name paradigm as a marker of prodromal Alzheimer's disease, and method to distinguish between MCI subtypes.