Miracle-dz/UniFAR-FTUs huggingface dataset:
The epidemiology of infantile hypertrophic pyloric stenosis in Sweden 1987–96

AIMS To find out whether the incidence of infantile hypertrophic pyloric stenosis (IHPS) has changed over the past decade, and if so, to investigate possible contributory factors. METHODS All infants undergoing pyloromyotomy for IHPS in Sweden between 1987 and 1996 were studied. Using the national patient registers the yearly incidence was determined and evaluated in relation to sex, latitude, urbanisation, and type of surroundings by use of a Poisson model. RESULTS There was a substantial decline from 2.7/1000 to 0.85/1000 over the time period. The incidence in the south was almost three times greater than in the north. CONCLUSION The declining incidence and geographical difference suggest that environmental factors are of importance in this disorder.
The first year of SN 2004dj in NGC 2403

New BV RI photometry and optical spectroscopy of the Type IIp supernova 2004dj in NGC 2403, obtained during the first year since discovery, are presented. The progenitor cluster, Sandage 96, is also detected on pre-explosion frames. The light curve indicates that the explosion occurred about 30 d before discovery, and the plateau phase lasted about +110 ± 20 d after that. The plateau-phase spectra have been modelled with the synow spectral synthesis code using H, Na i, Ti ii, Sc ii, Fe ii and Ba i lines. The SN distance is inferred from the expanding photosphere method and the standard candle method applicable for SNe IIp. They resulted in distances that are consistent with each other as well as earlier Cepheid and Tully–Fisher distances. The average distance, D= 3.47 ± 0.29 Mpc is proposed for SN 2004dj and NGC 2403. The nickel mass produced by the explosion is estimated as ∼0.02 ± 0.01 M⊙. The spectral energy distribution of the progenitor cluster is reanalysed by fitting population synthesis models to our observed BV RI data supplemented by U and JHK magnitudes from the literature. The χ2 minimization revealed a possible ‘young’ solution with cluster age Tcl= 8 Myr, and an ‘old’ solution with Tcl= 20–30 Myr. The ‘young’ solution would imply a progenitor mass M > 20 M⊙, which is higher than the previously detected progenitor masses for Type II SNe.
Efficacy of flupirtine on cognitive function in patients with CJD

Background: In cell culture experiments, flupirtine maleate (FLU), a triaminopyridine compound, was able to protect neuronal cells from apoptotic cell death induced by prion protein fragments and β-amyloid peptides. As FLU is a clinically safe drug, the authors started a double-blind placebo-controlled study in patients with Creutzfeldt–Jakob disease (CJD). Methods: Twenty-eight patients with CJD were randomized to an oral treatment with either FLU (n = 13) or matching placebo (PLA; n = 15). For inclusion and continuing the study, the patients had to achieve at least 50% in two of the subscales of the dementia tests employed. A battery of standardized questionnaires was employed to monitor the progression of the disease. The main outcome variable was the cognitive part of the Alzheimer’s Disease Assessment Scale (ADAS-Cog); the difference between baseline and the best score under treatment was defined as the primary efficacy variable for hypothesis testing. Results: CJD types were homogeneously distributed among the treatment groups. Patients treated with FLU showed significantly less deterioration in the dementia tests than patients treated with PLA. The mean change in ADAS-Cog (baseline to best) was +8.4 (±15.3) in the FLU group and +20.6 (±15.1) in the PLA group (p = 0.02, one-sided t-test). Conclusions: FLU has beneficial effects on cognitive function in patients with CJD. These positive results also may suggest a treatment potential of FLU in other neurodegenerative disorders. However, further studies are necessary.
Role of histopathological examination in nontraumatic perforation of colon.

AIM Nontraumatic perforation of colon is an uncommon cause of peritonitis requiring early surgical intervention. This study was carried out to determine the prevalence patterns of the different etiologies of nontraumatic perforation of colon. METHODS AND RESULTS A total of 35 patients with segments of colon or perforation margins removed for perforation were included. Most of the perforations occurred in the caecum, of which two were seen at the ileocaecal junction. The commonest cause was infection (amoebiasis: 13 cases and tuberculosis: 5 cases) followed by ulcers of non specific ulcers (12 cases). There were three cases of adenocarcinoma causing secondary perforation and one case of idiopathic intestinal gangrene and volvulus each. CONCLUSION In tropics, non traumatic perforations of colon most often involves caecal and ileocaecal segment and the most common etiology is amoebiasis.
Corner-field induced drain leakage in thin oxide MOSFETs

A new type of leakage current between drain and substrate (n-well) in thin oxide (120A-285A) n- and p-channel MOSFET's fabricated with standard CMOS n-well process is investigated. Experimental results indicate that the origin of this leakage is due to band-to-band tunneling occurring at the deep-depleted drain junction corner. It is shown that the tunnelingI-Vbehavior can be adequately described by the analytical expression ofJ = B_{1}E_{si} \exp (-B_{2}/E_{si}). The critical drain voltage corresponding to the onset of tunneling is empirically found to be 1.3 V higher in p-channel than in n-channel. Device structures with graded junctions, such as double-diffused and LDD, are also studied and demonstrated to be effective in suppressing this leakage current.
Heavy Metals and Metalloids As a Cause for Protein Misfolding and Aggregation

While the toxicity of metals and metalloids, like arsenic, cadmium, mercury, lead and chromium, is undisputed, the underlying molecular mechanisms are not entirely clear. General consensus holds that proteins are the prime targets; heavy metals interfere with the physiological activity of specific, particularly susceptible proteins, either by forming a complex with functional side chain groups or by displacing essential metal ions in metalloproteins. Recent studies have revealed an additional mode of metal action targeted at proteins in a non-native state; certain heavy metals and metalloids have been found to inhibit the in vitro refolding of chemically denatured proteins, to interfere with protein folding in vivo and to cause aggregation of nascent proteins in living cells. Apparently, unfolded proteins with motile backbone and side chains are considerably more prone to engage in stable, pluridentate metal complexes than native proteins with their well-defined 3D structure. By interfering with the folding process, heavy metal ions and metalloids profoundly affect protein homeostasis and cell viability. This review describes how heavy metals impede protein folding and promote protein aggregation, how cells regulate quality control systems to protect themselves from metal toxicity and how metals might contribute to protein misfolding disorders.
Gravity as BF theory plus potential

Spin foam models of quantum gravity are based on Plebanski's formulation of general relativity as a constrained BF theory. We give an alternative formulation of gravity as BF theory plus a certain potential term for the B-field. When the potential is taken to be infinitely steep one recovers general relativity. For a generic potential the theory still describes gravity in that it propagates just two graviton polarizations. The arising class of theories is of the type amenable to spin foam quantization methods, and, we argue, may allow one to come to terms with renormalization in the spin foam context.
Carrageenans, Sulphated Polysaccharides of Red Seaweeds, Differentially Affect Arabidopsis thaliana Resistance to Trichoplusia ni (Cabbage Looper)

Carrageenans are a collective family of linear, sulphated galactans found in a number of commercially important species of marine red alga. These polysaccharides are known to elicit defense responses in plant and animals and possess anti-viral properties. We investigated the effect of foliar application of ι-, κ- and λ-carrageenans (representing various levels of sulphation) on Arabidopsis thaliana in resistance to the generalist insect Trichoplusia ni (cabbage looper) which is known to cause serious economic losses in crop plants. Plants treated with ι- and κ-carrageenan showed reduced leaf damage, whereas those treated with λ- carrageenan were similar to that of the control. In a no-choice test, larval weight was reduced by more than 20% in ι- and κ- carrageenan treatments, but unaffected by λ-carrageenan. In multiple choice tests, carrageenan treated plants attracted fewer T. ni larvae by the fourth day following infestation as compared to the control. The application of carrageenans did not affect oviposition behaviour of T. ni. Growth of T. ni feeding on an artificial diet amended with carrageenans was not different from that fed with untreated control diet. ι-carrageenan induced the expression of defense genes; PR1, PDF1.2, and TI1, but κ- and λ-carrageenans did not. Besides PR1, PDF1.2, and TI1, the indole glucosinolate biosynthesis genes CYP79B2, CYP83B1 and glucosinolate hydrolysing QTL, ESM1 were up-regulated by ι-carrageenan treatment at 48 h post infestation. Gas chromatography-mass spectrometry analysis of carrageenan treated leaves showed increased concentrations of both isothiocyanates and nitriles. Taken together, these results show that carrageenans have differential effects on Arabidopsis resistance to T. ni and that the degree of sulphation of the polysaccharide chain may well mediate this effect.
A multiplicative model for improving microvascular flow estimation in dynamic contrast-enhanced ultrasound (DCE-US): theory and experimental validation

Perfusion parameter estimation from dynamic contrast-enhanced ultrasound (DCE-US) data relies on fitting parametric models of flow to curves describing linear echo power as a function of time. The least squares criterion is generally used to fit these models to data. This criterion is optimal in the sense of maximum likelihood under the assumption of an additive white Gaussian noise. In the current work, it is demonstrated that this assumption is not held for DCEUS. A better-adapted maximum likelihood criterion based on a multiplicative model is proposed. It is tested on simulated bolus perfusion data and on 11 sequences acquired in vivo during bolus perfusion of contrast agent in the cortex of healthy murine kidney, an area where the perfusion is expected to be approximately homogeneous. Results on simulated data show a significant improvement (p <; 0.05) of the precision and the accuracy for the estimations of perfusion parameters time to peak (TTP), wash-in rate (WiR), and mean transit time (MTT). On the 11 in vivo sequences, the new method leads to a significant reduction (p <; 0.05) in the variation of parametric maps for 9 sequences for TTP and 10 sequences for WiR and MTT. The mean percent decreases of the coefficient of variation are 40%, 25%, and 59% for TTP, WiR, and MTT, respectively. This method should contribute to a more robust and accurate estimation of perfusion parameters and an improved resolution of parametric imaging.
Evaluating marginal likelihood with thermodynamic integration method and comparison with several other numerical methods

Evaluating marginal likelihood is the most critical and computationally expensive task, when conducting Bayesian model averaging to quantify parametric and model uncertainties. The evaluation is commonly done by using Laplace approximations to evaluate semianalytical expressions of the marginal likelihood or by using Monte Carlo (MC) methods to evaluate arithmetic or harmonic mean of a joint likelihood function. This study introduces a new MC method, i.e., thermodynamic integration, which has not been attempted in environmental modeling. Instead of using samples only from prior parameter space (as in arithmetic mean evaluation) or posterior parameter space (as in harmonic mean evaluation), the thermodynamic integration method uses samples generated gradually from the prior to posterior parameter space. This is done through a path sampling that conducts Markov chain Monte Carlo simulation with different power coefficient values applied to the joint likelihood function. The thermodynamic integration method is evaluated using three analytical functions by comparing the method with two variants of the Laplace approximation method and three MC methods, including the nested sampling method that is recently introduced into environmental modeling. The thermodynamic integration method outperforms the other methods in terms of their accuracy, convergence, and consistency. The thermodynamic integration method is also applied to a synthetic case of groundwater modeling with four alternative models. The application shows that model probabilities obtained using the thermodynamic integration method improves predictive performance of Bayesian model averaging. The thermodynamic integration method is mathematically rigorous, and its MC implementation is computationally general for a wide range of environmental problems.
Self-Organizing Into Winning Teams: Understanding the Mechanisms That Drive Successful Collaborations

Contemporary teams are self-assembling with increasing frequency, meaning the component members are choosing to join forces with some degree of agency rather than being assigned to work with one another. However, the majority of the teams literature up until this point has focused on randomly assigned or staffed teams. Thus, the purpose of the current study was to investigate how people do form into teams and how people should form into teams. Specifically, we utilized a sample of digital traces from a massively multiplayer online role-playing game (N = 1,568) to evaluate the bases for and performance implications of team self-assembly. The results indicated that self-assembled teams form via three mechanisms: homophily, familiarity, and proximity. Moreover, results of the trace data analyses indicated that successful and unsuccessful teams were homogeneous in terms of different characteristics, and successful teams formed based on friendship more often than unsuccessful teams did.
A new megastigmane sulphoglycoside and polyphenolic constituents from pericarps of Garcinia mangostana

Abstract A megastigmane sulphoglycoside together with three phenolic compounds were isolated from the water-soluble fraction of the pericarps of Garcinia mangostana. The structure of the new compound was determined as 4-O-sulpho-β-d-glucopyranosyl abscisate (1) by spectroscopic data. Proanthocyanidin A2 (2) showed potent α-glucosidase inhibitory and DPPH scavenging activities with IC50 values of 3.46 and 11.6 μM, respectively.
Interaction of the PAS B Domain with HSP90 Accelerates Hypoxia-Inducible Factor-1α Stabilization

Hypoxia-inducible factor (HIF) α subunits are induced under hypoxic conditions, when limited oxygen supply prevents prolyl hydroxylation-dependent binding of the ubiquitin ligase pVHL and subsequent proteasomal degradation. A short normoxic half-life of HIF-α and a very rapid hypoxic protein stabilization are crucial to the cellular adaptation to changing oxygen supply. However, the molecular requirements for the unusually rapid mechanisms of protein synthesis, folding and nuclear translocation are not well understood. We and others previously found that the chaperone heat-shock protein 90 (HSP90) can interact with HIF-1α in vitro. Here we show that HSP90 also interacts with HIF-2α and HIF-3α, suggesting a general involvement of HSP90 in HIF-α stabilization. The PAS B domain, common to all three α subunits, was required for HSP90 interaction. ARNT competed with HSP90 for binding to the PAS B domain since an excess of either component inhibited the activity of the other. HSP90 as well as the heterocomplex members HSP70 and p23, but not HSP40, were detected in immunoprecipitations of endogenous cellular HIF-1α. While HSP90 and HSP70 bound to HIF-1α predominantly under normoxic conditions, ARNT bound to HIF-1α primarily under hypoxic conditions, suggesting that ARNT displaced HSP90 from HIF-1α following nuclear translocation. Hypoxic accumulation of HIF-1α was delayed in a novel cell model deficient for HSP90β as well as after treatment of wild-type cells with the HSP90 inhibitor geldanamycin, suggesting that HSP90 activity is involved in the rapid HIF-1α protein induction.
Reliability and Validity of the Japanese Version of the Coping Inventory for Adults for Stressful Situations in Healthy People

The present study examined the validity and reliability of the Japanese version of the Coping Inventory for Stressful Situations-2nd Edition™ (CISS; hereafter the CISS–J). The participants were 1,268 healthy Japanese individuals. The factor analyses yielded three major scales (task-, emotion-, and avoidance-oriented coping) corresponding to the original version. In addition, the avoidance-oriented scale of the CISS–J contained two subscales (Distraction and Social diversion), as in the original version. Cronbach's α coefficient was found to be . 75–. 89 for the three scales and two subscales. Results show that the CISS–J is useful for assessing the coping strategies among this sample of Japanese individuals.
A Fast Signal–Induced Activation of Poly(Adp-Ribose) Polymerase

We present the first evidence for a fast activation of the nuclear protein poly(ADP-ribose) polymerase (PARP) by signals evoked in the cell membrane, constituting a novel mode of signaling to the cell nucleus. PARP, an abundant, highly conserved, chromatin-bound protein found only in eukaryotes, exclusively catalyzes polyADP-ribosylation of DNA-binding proteins, thereby modulating their activity. Activation of PARP, reportedly induced by formation of DNA breaks, is involved in DNA transcription, replication, and repair. Our findings demonstrate an alternative mechanism: a fast activation of PARP, evoked by inositol 1,4,5,-trisphosphate–Ca2+ mobilization, that does not involve DNA breaks. These findings identify PARP as a novel downstream target of phospholipase C, and unveil a novel fast signal–induced modification of DNA-binding proteins by polyADP-ribosylation.
A class of edit kernels for SVMs to predict translation initiation sites in eukaryotic mRNAs

The prediction of translation initiation sites (TISs) in eukaryotic mRNAs has been a challenging problem in computational molecular biology. In this paper, we present a new algorithm to recognize TISs with a very high accuracy. Our algorithm includes two novel ideas. First, we introduce a class of new sequence-similarity kernels based on string edit, called the edit kernels, for use with support vector machines (SVMs) in a discriminative approach to predict TISs. The edit kernels are simple and have significant biological and probabilistic interpretations. Second, we convert the region of an input mRNA sequence downstream to a putative TIS into an amino acid sequence before applying SVMs to avoid the high redundancy in the genetic code. The algorithm has been implemented and tested on previously published data. Our experimental results on real mRNA data show that both ideas improve the prediction accuracy greatly and our method performs significantly better than those based on neural networks and SVMs with polynomial kernels or Salzberg kernel.
Murine dendritic cells loaded in vitro with soluble protein prime cytotoxic T lymphocytes against tumor antigen in vivo

The priming of an immune response against a major histocompatibility complex class I-restricted antigen expressed by nonhematopoietic cells involves the transfer of that antigen to a host bone marrow-derived antigen presenting cell (APC) for presentation to CD8+ T lymphocytes. Dendritic cells (DC), as bone marrow-derived APC, are first candidates for presentation of tumor-associated antigens (TAA). The aim of this study was to see whether DC are able to prime in vivo antigen-specific cytotoxic T lymphocytes after exposure to a soluble protein antigen in vitro. Lacking a well-defined murine TAA, we took advantage of beta- galactosidase (beta-gal)-transduced tumor cell lines as a model in which beta-gal operationally functions as TAA. For in vivo priming both a DC line, transduced or not transduced with the gene coding for murine GM-CSF, and fresh bone marrow-derived DC (bm-DC), loaded in vitro with soluble beta-gal, were used. Priming with either granulocyte macrophage colony-stimulating factor-transduced DC line or fresh bm-DC but not with untransduced DC line generated CTL able to lyse beta-gal- transfected target cells. Furthermore, GM-CSF was necessary for the DC line to efficiently present soluble beta-gal as an H-2Ld-restricted peptide to a beta-gal-specific CTL clone. Data also show that a long- lasting immunity against tumor challenge can be induced using beta-gal- pulsed bm-DC as vaccine. These results indicate that effector cells can be recruited and activated in vivo by antigen-pulsed DC, providing an efficient immune reaction against tumors.
Cancer bytes.

Background: It is not clear whether environmental exposure to dioxin affects the general population. The aim of this research is to evaluate sarcoma risk in relation to the environmental pollution caused by dioxin emitted by waste incinerators and industrial sources of airborne dioxin. The study population lives in a part of the Province of Venice (Italy), where a population-based cancer registry (Veneto Tumour Registry – RTV) has been active since 1987. Methods: Two hundred and five cases of visceral and extravisceral sarcoma, confirmed by microscopic examination, diagnosed from 01.01. 1990 to 31.12. 1996, were extracted from the RTV database. Diagnoses were revised using the actual pathology reports and clinical records. For each sarcoma case, three controls of the same age and sex were randomly selected from the population files of the Local Health Units (LHUs). The residential history of each subject, whether case or control, was reconstructed, address by address, from 1960 to the date of diagnosis. All waste incinerators and industrial sources of airborne dioxin in the Province of Venice were taken into account, as was one very large municipal waste incinerator outside the area but close to its boundaries. The Industrial Source Complex Model in Long Term mode, version 3 (ISCLT3), was used to assess the level of atmospheric dispersion. A specific value for exposure was calculated for each point (geo-referenced address) and for each calendar year; the exposure value for each subject is expressed as the average of specific time-weighted values. The analysis takes into account 172 cases and 405 controls, aged more than 14 years. Results: The risk of developing a sarcoma is 3.3 times higher (95% Confidence Interval – 95% CI: 1.24 – 8.76) among subjects, both sexes, with the longest exposure period and the highest exposure level ; a significant excess of risk was also observed in women (Odds Ratio OR = 2.41, 95% CI: 1.04 – 5.59) and for cancers of the connective and other soft tissue (International Classification of Diseases, ninth Revision – ICD-IX 171), both sexes (OR = 3.27, 95% CI: 1.35 – 7.93). Conclusion: Our study supports the association between modelled dioxin exposure and sarcoma risk. Published: 16 July 2007 Environmental Health 2007, 6:19 doi:10.1186/1476-069X-6-19 Received: 15 January 2007 Accepted: 16 July 2007 This article is available from: http://www.ehjournal. net/content/6/1/19 © 2007 Zambon et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.