Miracle-dz/UniFAR-FTUs huggingface dataset:
Comparative CD4 T-Cell Responses of Reverse Transcriptase Inhibitor Therapy With or Without Nelfinavir Matched for Viral Exposure

Abstract Background: Therapy of HIV infection with protease inhibitors (PIs) may be associated with improvements in CD4 T-cell number via a mechanism that is independent of effects on plasma viral load (VL). Purpose: To compare CD4 responses of patients who receive reverse transcriptase inhibitor (RTI) therapies with or without a PI, matched for viral exposure. METHODS: Patient data were analyzed from two prospective randomized trials of antiviral therapy with or without nelfinavir. Total viral exposure over 24 weeks was estimated by viral area under the curve (AUC), which reflects baseline viral load, slope of virologic decay, viral nadir, and duration of suppression. Patients were stratified into quartiles on the basis of viral AUC, and CD4 T-cell responses were evaluated between PI-containing and RTI-only treatment groups within each quartile. Results: In both trials, patients receiving nelfinavir had greater CD4 T-cell increases than patients receiving RTI alone. Analysis of variance modeling revealed increased CD4 T-cell responses in PI-treated groups at all time points after the second week. These differences were significant (p < .05) at weeks 12, 24, 28, 32, 36, 40, and 48 in one study, and weeks 1, 2, 4, 6, 8, 12, 16, 20, 24, 28, 32, 36, and 44 in the other. Within quartiles matched for viral AUC, absolute CD4 T-cell change from baseline was greater in the PI-treated patients at 84% (101/120) of time points analyzed. Conclusion: Nelfinavir-containing therapy is associated with enhanced increases in CD4 T-cell number compared to RTI therapy alone with equivalent antiviral effect. These data suggest that PIs influence CD4 T-cell number through a nonvirologic effect.
Data-driven models for mortality assessment at the Intensive Care Unit Research Paper Business Analytics

The Intensive Care Unit (ICU) is known as the department with the highest mortality numbers in any hospital. Patients at the ICU require extensive assessment by hospital staff. This is partially achieved through the use of state-oftheart monitoring devices that provide measurements and trends about each patient. This means that large amounts of useful data is available for research. With the increasing number of patients, maintaining a high standard of care at the ICU becomes time consuming and brings high operational costs with it. In this paper we develop data-driven models that can be used by hospital staff to assess the physical state of patients at the ICU. To be more precise, these models provide hospital staff with predictions about the risk of mortality of patients at the ICU. Two models were developed and compared based on accuracy and scalability. The first approach follows a pipeline that prepares the data for predictive modelling with logistic regression. The second approach allows the use of the instance-based learning model K-nearest neighbor (KNN) with Dynamic Time Warping (DTW). We show that logistic regression (AUC of 0.84) significantly outperforms KNN (AUC of 0.68) by conventional criteria. This paper provides insights on the performance of both algorithms and could be used as inspiration for further research.
Gamma Irradiation of in-Shell and Blanched Peanuts Protects against Mycotoxic Fungi and Retains Their Nutraceutical Components during Long-Term Storage

Peanut samples were irradiated (0.0, 5.2, 7.2 or 10.0 kGy), stored for a year (room temperature) and examined every three months. Mycotoxic fungi (MF) were detected in non-irradiated blanched peanuts. A dose of 5.2 kGy was found suitable to prevent MF growth in blanched samples. No MF was detected in in-shell peanuts, with or without irradiation. The colors of the control in-shell and blanched samples were, respectively, 44.72 and 60.21 (L *); 25.20 and 20.38 (Chroma); 53.05 and 86.46 (°Hue). The water activities (Aw) were 0.673 and 0.425. The corresponding fatty acids were 13.33% and 12.14% (C16:0), 44.94% and 44.92% (C18:1, ω9) and 37.10% and 37.63% (C18:2, ω6). The total phenolics (TP) were 4.62 and 2.52 mg GAE/g, with antioxidant activities (AA) of 16.97 and 10.36 μmol TEAC/g. Storage time negatively correlated with Aw (in-shell peanuts) or L *, linoleic acid, TP and AA (in-shell and blanched peanuts) but positively correlated with Aw (blanched peanuts), and with oleic acid (in-shell and blanched peanuts). Irradiation positively correlated with antioxidant activity (blanched peanuts). No correlation was found between irradiation and AA (in-shell samples) or fatty acids and TP (in-shell and blanched peanuts). Irradiation protected against MF and retained both the polyunsaturated fatty acids and polyphenols in the samples.
Temporal Residual Networks for Dynamic Scene Recognition

This paper combines three contributions to establish a new state-of-the-art in dynamic scene recognition. First, we present a novel ConvNet architecture based on temporal residual units that is fully convolutional in spacetime. Our model augments spatial ResNets with convolutions across time to hierarchically add temporal residuals as the depth of the network increases. Second, existing approaches to video-based recognition are categorized and a baseline of seven previously top performing algorithms is selected for comparative evaluation on dynamic scenes. Third, we introduce a new and challenging video database of dynamic scenes that more than doubles the size of those previously available. This dataset is explicitly split into two subsets of equal size that contain videos with and without camera motion to allow for systematic study of how this variable interacts with the defining dynamics of the scene per se. Our evaluations verify the particular strengths and weaknesses of the baseline algorithms with respect to various scene classes and camera motion parameters. Finally, our temporal ResNet boosts recognition performance and establishes a new state-of-the-art on dynamic scene recognition, as well as on the complementary task of action recognition.
Predicting Delays in Software Projects Using Networked Classification (T)

Software projects have a high risk of cost and schedule overruns, which has been a source of concern for the software engineering community for a long time. One of the challenges in software project management is to make reliable prediction of delays in the context of constant and rapid changes inherent in software projects. This paper presents a novel approach to providing automated support for project managers and other decision makers in predicting whether a subset of software tasks (among the hundreds to thousands of ongoing tasks) in a software project have a risk of being delayed. Our approach makes use of not only features specific to individual software tasks (i.e. local data) -- as done in previous work -- but also their relationships (i.e. networked data). In addition, using collective classification, our approach can simultaneously predict the degree of delay for a group of related tasks. Our evaluation results show a significant improvement over traditional approaches which perform classification on each task independently: achieving 46% -- 97% precision (49% improved), 46% -- 97% recall (28% improved), 56% -- 75% F-measure (39% improved), and 78% -- 95% Area Under the ROC Curve (16% improved).
Assessing anger in people with intellectual disability

Abstract Background There is a growing interest in the use of cognitive approaches for the treatment of psychological difficulties with people who have intellectual disability. The aim of the present study was to investigate the properties of an anger inventory, the relationship between self-reported and staff-reported levels of anger, and the relationship between different staff measures. Method Two studies are described that use self-report and staff-report measures. The first study employs a cross sectional design and the second, a longitudinal design. Results No relationship was found between self-reported and staff-reported levels of anger on the first measurement occasion, but on the second measurement occasion after some intervention a significant relationship was found. If staff had accompanied individuals during an intervention a larger correlation was found. Conclusion These results suggest that staff may require specific training or exposure to a therapeutic environment before they can predict the response of people with intellectual disability on the anger inventory. This suggests that involvement of care staff in interventions may be useful therapeutically.
A Depletion-Mode a-IGZO TFT Shift Register With a Single Low-Voltage-Level Power Signal

We proposed and fabricated a new depletion-mode amorphous indium-gallium-zinc-oxide thin-film-transistor (a-IGZO TFT) shift register. Although only one low-voltage-level power signal (VGL) rather than widely used two ones was employed, the depletion-mode a-IGZO TFTs in the proposed shift register were turned off completely due to a series-connected two-transistor structure. The proposed shift register exhibited successfully a high-voltage output pulse. The power consumption of the shift register with ten stages is 1.67 mW at the high-voltage-level power signal of 20 V, the VGL of -5 V, and the clock frequency of 13.9 kHz.
Long-time visual functional results of cataract surgery on low vision patients

Background/aims To assess longitudinal 5-year results of cataract surgery on low vision patients. Methods In this prospective, long-time, observational case-series, we report the outcome regarding the subjective visual function (n = 35) assessed by a visual function questionnaire (VF-14) and the visual acuity (n = 30) of surviving low vision patients 5 years after surgery. We compare with data recorded on the same patients before surgery and 4 months postoperatively. Results Five years after surgery, 57% had unchanged or better VF-14 score compared with preoperatively, and 37% compared with postoperatively. Maculopathy patients had a significantly larger deterioration 5 years after surgery compared with postoperatively (40.2 versus 51.7, p = 0.004), but for the glaucoma patients there was no significant change (52.6 versus 53.1). There were no significant associations between age of the patient and change in VF-14 score or change in visual acuity 5 years after surgery, neither compared with before surgery nor postoperatively. Conclusion Results suggest a favorable functional outcome 5 years after cataract surgery on most low-vision patients. Glaucoma patients have a more stable outcome than patients with macular degeneration. The severity of the disease-process for each individual patient might be the most important factor affecting the long-time results.
Technological innovation systems for microgeneration in the UK and Germany – a functional analysis

This paper examines the deployment of microgeneration in Germany and the UK from a technological innovation systems (TIS) perspective. Based on the TIS functions approach, we condense supportive and obstructive factors and discuss the differences in the respective national setting for small-scale renewable and combined heat and power (CHP) technologies. The findings underline the relevance of legitimation and of institutional and financial support. High degrees of legitimacy were achieved in both the UK and Germany. In Germany, early institutional and financial support reduced uncertainty for new market entrants and consumers, and fuelled a self-reinforcing diffusion dynamic for small renewables. In the UK, by comparison, microgeneration enjoys little support. The paper concludes that distributed generation will not be successful without a more focussed and technology-oriented innovation policy.
Cardio-oncology: a new medical issue

Due to the increasing number of long-term cancer survivors, the ageing of the population, as well as the increased incidence and prevalence of oncologic and cardiovascular diseases, the number of patients presenting oncologic and cardiologic co-morbidities are increasing. Accordingly, there is a rapidly growing need for a comprehensive and proficient management of patients in whom the two co-morbidities exist, and for cancer patients whose clinical history and oncologic treatment put them at higher risk for developing cardiovascular problems, in order to provide the optimal treatment in every situation, and to avoid the possibility that the development of the second disease does not lead to a reduction of therapeutic opportunities for the patient. A new discipline, cardio-oncology, has been created to deal with this need. Its aim is to investigate new strategies, collect new evidence-based indications and develop interdisciplinary expertise in order to manage this growing category of patients. Cardio-oncology deals with the following main clinical and research areas: early diagnosis of cardiotoxicity, risk stratification and preventions, treatment and monitoring of cardiotoxicity.
The Effectiveness of a Flipped Classroom Approach Unit on Student Knowledge, Skill Development, and Perception of Collegiate Physical Education

ii Acknowledgments iii List of Tables vi List of Figures vii Chapter 1 Introduction 1 Chapter 2 Literature Review 13 Chapter 3 Research Methods 40 Chapter 4 Findings 59 Chapter 5 Discussion and Conclusion 97 References 115 Appendix A 125 Appendix B 146 Appendix C 151 Appendix D 178 Appendix E 179 Appendix F 181 Appendix G 183 Appendix H 184 Appendix I 186 Appendix J 188
Impact of a Designed Nursing Teaching Protocol on Quality of Life of Patients with Chronic Lower Limb Ischemia at Assiut University Hospital

Chronic lower limb ischemia is a prevalent systemic atherosclerotic disease that impairs a patient's quality of life and untreated disease can lead to limb loss. The aim was; to evaluate the impact of a designed nursing teaching protocol on quality of life of patients with chronic lower limb ischemia. Research hypotheses; Participants will have less disease symptoms as compared to prior application of nursing protocol, The functional capacity will improve as presented by ankle brachial index, The knowledge of studied patients after application of nursing protocol will be higher than their knowledge before protocol, and quality of life of participants will improve. A quasi – experimental research design was utilized. The study was conducted at vascular surgery department and its outpatient clinics of Assuit University Hospital. A convenience sample of sixty adult male and female patients. Tools for data collection; tool I "Patients' structured assessment sheet", tool II “Vascular quality of life questionnaire". The control group exposed to routine hospital care and assessed two times by using tool I and tool II. While study group patients received the contents of the designed nursing teaching protocol and assessed two times also by using the same tools. Data was collected & analyzed. Results concluded that; all patients in both groups were having unsatisfactory level of knowledge about disease in the time of admission. While in the time of follow up; the control group still had unsatisfactory level of knowledge and most of the study group patients became having satisfactory level of knowledge which reflected into their quality of life. As their quality of life became good. Theses study findings documented that; the more information the patient is provided the better equips to manage this chronic disorder . Keywords: Nursing teaching protocol, Quality of life, Chronic lower limb ischemia.
Synthesis , characterization and photocatalytic activity of TiO 2 supported natural palygorskite micro fi bers

Bouna, L. and Rhouta, B. and Amjoud, M. and Maury, Fr ancis and Lafont, Marie-Christine and Jada, A. and Senocq, François and D aoudi, L. Synthesis, characterization and photocatalytic activity of TiO2 supported natural palygorskite microfibers. (2011) Applied Clay Science, vol. 52 (n° 3). pp. 301-311. ISSN 0169-1317 Open Archive Toulouse Archive Ouverte (OATAO) OATAO is an open access repository that collects the work of Toulouse researchers and makes it freely available over the web where possible .
Sparsity-constrained generalized bilinear model for hyperspectral unmixing

Generalized bilinear model (GBM) has been widely used for nonlinear hyperspectral image unmixing. However, it does not take the sparse information of abundance into account, which is a significant characteristic resulting from the correlation of hyperspectral data. This paper aims to extend the GBM by incorporating the sparsity constraint of abundance matrix with the semi-nonnegative matrix factorization, by dividing GBM into the linear part and the second-order part, which are optimized using an alternating optimization algorithm respectively. L1/2-norm is used to explore the sparse characteristic, and the L1/2-constrained semi-nonnegative matrix factorization (L1/2-semi-NMF) algorithm is presented, which leads to better results on both synthetic and real data.
Tip-of-the-tongue states and related phenomena

1. Why tip-of-the-tongue states are important Alan S. Brown and Bennett L. Schwartz 2. Tip-of-the-tongue (TOT) states: mechanisms and metacognitive control Bennett L. Schwartz and Janet Metcalfe 3. There it is again on my tongue: tracking repeat TOTs Alan S. Brown and Katie Croft Caderao 4. Retrieval failures for the names of familiar people J. Richard Hanley 5. The effect of tip-of-the-tongue states on other cognitive judgments Anne M. Cleary, Shelly R. Staley and Kimberly R. Klein 6. Why the journey to a word takes you no closer Trevor A. Harley 7. Tip-of-the-tongue in mild cognitive impairment (MCI) Onesimo Juncos-Rabadan, David Facal and Arturo X. Pereiro 8. Metamemory and Parkinson's disease Justin D. Oh-Lee and Hajime Otani 9. Psychopharmacological approach of the metamemory and TOT phenomenon Marie Izaute and Elisabeth Bacon 10. Neurofunctional correlates of the tip-of-the-tongue state Fernando Diaz, Monica Lindln, Santiago Galdo-Alvarez and Ana Bujan 11. The blank in the mind experience: another manifestation of tip-of-the-tongue state or something else? Anastasia Efklides 12. On the empirical study of dej. vu: borrowing methodology from the study of the tip-of-the-tongue phenomenon Anne M. Cleary 13. Dej. vu in older adults Chris J. A. Moulin, Celine Souchay, Sarah Buchanan, Rosemary Bradley, Dilay Zeynep Karadoller and Melisa Akan 14. Odor knowledge, odor naming, and the 'tip-of-the-nose' experience Frederik U. Jonsson and Richard J. Stevenson 15. What do we know when we forget? Asher Koriat and Ravit Nussinson.
Cytoskeleton Aberrations in Alkaptonuric Chondrocytes

Alkaptonuria (AKU) is an ultra‐rare autosomal genetic disorder caused by a defect in the activity of the enzyme homogentisate 1,2‐dioxygenase (HGD) that leads to the accumulation of homogentisic acid (HGA) and its oxidized product, benzoquinone acetic acid (BQA), in the connective tissues causing a pigmentation called “ochronosis. ” The consequent progressive formation of ochronotic aggregates generate a severe condition of oxidative stress and inflammation in all the affected areas. Experimental evidences have also proved the presence of serum amyloid A (SAA) in several AKU tissues and it allowed classifying AKU as a secondary amyloidosis. Although AKU is a multisystemic disease, the most affected system is the osteoarticular one and articular cartilage is the most damaged tissue. In this work, we have analyzed for the first time the cytoskeleton of AKU chondrocytes by means of immunofluorescence staining. We have shown the presence of SAA within AKU chondrocytes and finally we have demonstrated the co‐localization of SAA with three cytoskeletal proteins: actin, vimentin, and β‐tubulin. Furthermore, in order to observe the ultrastructural features of AKU chondrocytes we have performed TEM analysis, focusing on the Golgi apparatus structure and, to demonstrate that pigmented areas in AKU cartilage are correspondent to areas of oxidation, 4‐HNE presence has been evaluated by means of immunofluorescence. J. Cell. Physiol. 232: 1728–1738, 2017. © 2016 Wiley Periodicals, Inc.
School-Based Curriculum Development in China

In an attempt to give a general but critical review of school-based curriculum development (SBCD) in China's new curriculum reform (NCR), this article discusses at length some issues remaining in SBCD, including misconceptions in Chinese discussions about SBCD, most significantly, the Chinese literal expression of the policy statement on three-level curriculum management and its vague implications for SBCD; the tensions between curriculum reform experts and curriculum scholars; and the chasm between the policy and its practice. The article has three interrelated parts: a text analysis of the policy statement, an argumentation analysis of some illustrative controversial theoretical viewpoints on SBCD, and a practical analysis of the explorations in schools in various areas of China.
Effects of Arrest on Intimate Partner Violence Incidence and Revictimization: Logistic Regression and Regression Time Series Analysis of the National Crime Victimization Survey from 1987 to 2003

The police have actively intervened in intimate partner violence (IPV) since the 1980’s to hold batterers accountable by legal punishment, to prevent future violence, and to provide victims’ safety. However, research results of the effectiveness of the police intervention are inconclusive. Moreover, the majority of studies focused on batterers, overlooking victim-related factors in examining the effectiveness of the police intervention. This paper used the National Crime Victimization Survey from 1987 to 2003 to examine whether arrest of batterers has an effect in reducing revictimization. Overall, younger, separated victims are more likely to be revictimized than the older, married women. Rape or sexual assault victims and those without injury from the previous victimization are more vulnerable to revictimization. Also, IPV incidence rates declined by half, and arrest rates of batterers were doubled from 1987 to 2004. With regard to the effect of arrest, the study results support the specific effect of arrest on victims’ safety. Logistic regression analysis of data from 2,462 victims showed that when the police arrested batterers, their chance of revictimization fell by half. However, the general effect of arrest on incidence rates is not as apparent as the specific effect. The time-lagged effect of arrest on incidence rates, which was shown in this study, needs future research for meaningful interpretation because there is no theory to explain such a delayed effect. Since dual-examination of the specific effect and the general effect showed the overall effectiveness of arrest in reducing IPV incidence and revictimization, social work policy and practice fields will be able to develop informed, effective intervention strategies in IPV.
Teacher Activities and Adolescent Students’ Participation in a Colombian EFL Classroom

The present study concerns the activities teachers develop and ninth-graders’ participation in responses to those activities. The objectives of this study were to identify and describe the types of teaching activities developed and how students respond to them and to show how the target language is used in the classroom. The data collection was conducted through daily field notes and a diary. The findings show that in the classroom, the teacher develops twelve types of activities, and the percentage of use of the target language is low.