Miracle-dz/UniFAR-FTUs huggingface dataset:
The Shakespeare Authorship Question

Many in academic world accept as fact that William Shakespeare of Stratford-upon-Avon was the pen behind such works as Romeo and Juliet, King Lear etc. However there has been a debate dating back to the 18th century about whether the works attributed to the famed playwrite where actually composed by another writer. The debate thus far has been focused on the lack of historic records concerning Shakespeare’s life, as well as the evidence of a level of higher learning present in Shakespeare’s works inconsistant with Shakespeare’s background. This paper however well use modern text-analysis and datamining techniques to analize the works attributed to Shakespeare and several leading alternaive candidates in an attempt to provide a more concrete answer to the authorship question.
Performance Optimization of Saturated PID Controller for Robot Manipulators

In this paper a new approach to performance tuning of saturated PID controller for robot manipulators is presented. The proposed approach is based on construction of a parameter dependent Lyapunov function. With the appropriate choice of the free parameter, which is not included in stability conditions, a estimation of integral performance index is obtained. The performance index depends on controller parameters and few parameters which characterize the robot dynamics. The optimal values of the controller gains are obtained by minimization of the performance index. An example is given to demonstrate the obtained results.
Aviation-Climate Change Research Initiative (ACCRI) Subject Specific White Paper (SSWP) on Contrail/Cirrus Optics and Radiation

Persistent contrails and contrail-cirrus that are formed in the upper troposphere and lower stratosphere may play an important role in regulating the radiation balance in the Earth-atmosphere system through the competition between the solar-albedo and greenhouse effects that are determined by the ice crystal microphysical and radiative properties within these clouds. The major issue is whether increasing jet air traffic will enhance the generation of additional cirrus clouds, which can lead to an amplification of global warming caused by the build-up of carbon dioxide and other trace gases in the atmosphere. This paper presents a literature review of developments regarding the impact of contrails and contrail cirrus on the radiation field of the Earth’s atmosphere and climate. It also provides recommendations for future actions.
Integration of Analytical Quality Assurance Methods into Agile Software Construction Practice Research Proposal for a Family of Controlled Experiments

Defects in early software development products, e.g., design specifications, can have a major impact on product quality. Analytical quality assurance methods, like Software Inspections and Testing are common practices for detecting non-conformities in software products. Often, these quality assurance (QA) activities are not seen as integral part of software construction process but rather as time-and-budget-consuming add-on activities, which may be cut short if the remaining budget becomes tight. Agile software development practices, such as pair programming, focus on software construction, with some basic elements of quality assurance, e.g., continuous reviews. Several empirical studies reported on defect reduction in software products and on productivity improvements of pairs compared to solo programming. To bundle the benefits from agile development practice and structured quality assurance activities, we propose a pair programming (PP) approach that integrates best-practice inspection and usage-based testing (see ISERN 2004 poster session). This approach is expected to bring several benefits: (a) increased product quality, (b) increased business value contribution of PP by applying prioritized use cases, (c) improved understanding of customer requirements, and (d) extending application opportunities of agile methods to more critical software systems, which require auditable QA activities. Based on this integrated PP model we propose to conduct a family of experiments to investigate defect detection capability and learning effects. Additionally, the experiment setup will address the theoretical background (Empirical Software Engineering theory building) on the necessary number of participants to achieve empirical evidence, improve reporting theory of empirical studies and improve hypothesis building processes.
Morphological and Pathological Evolution of the Brain Microcirculation in Aging and Alzheimer’s Disease

Key pathological hallmarks of Alzheimer’s disease (AD), including amyloid plaques, cerebral amyloid angiopathy (CAA) and neurofibrillary tangles do not completely account for cognitive impairment, therefore other factors such as cardiovascular and cerebrovascular pathologies, may contribute to AD. In order to elucidate the microvascular changes that contribute to aging and disease, direct neuropathological staining and immunohistochemistry, were used to quantify the structural integrity of the microvasculature and its innervation in three oldest-old cohorts: 1) nonagenarians with AD and a high amyloid plaque load; 2) nonagenarians with no dementia and a high amyloid plaque load; 3) nonagenarians without dementia or amyloid plaques. In addition, a non-demented (ND) group (average age 71 years) with no amyloid plaques was included for comparison. While gray matter thickness and overall brain mass were reduced in AD compared to ND control groups, overall capillary density was not different. However, degenerated string capillaries were elevated in AD, potentially suggesting greater microvascular “dysfunction” compared to ND groups. Intriguingly, apolipoprotein ε4 carriers had significantly higher string vessel counts relative to non-ε4 carriers. Taken together, these data suggest a concomitant loss of functional capillaries and brain volume in AD subjects. We also demonstrated a trend of decreasing vesicular acetylcholine transporter staining, a marker of cortical cholinergic afferents that contribute to arteriolar vasoregulation, in AD compared to ND control groups, suggesting impaired control of vasodilation in AD subjects. In addition, tyrosine hydroxylase, a marker of noradrenergic vascular innervation, was reduced which may also contribute to a loss of control of vasoconstriction. The data highlight the importance of the brain microcirculation in the pathogenesis and evolution of AD.
Relational Communication Messages and Employee Outcomes in Supervisor/Employee Relationships

Supervisors’ relational communication messages were used to predict specific employee outcomes. In the study, 307 participants working in various industries completed measures of relational communication about their direct supervisor along with measures of their job satisfaction, motivation, and organizational commitment. As predicted, intimacy, composure, and equality messages were positively related to job satisfaction, motivation, and organizational commitment. Dominance and formality messages were negatively related to job satisfaction, motivation, and organizational commitment. Regression analyses determined that affection/involvement, similarity/depth, and composure were the strongest predictors of employee outcomes.
Growing Hierarchical Scale-Free Networks by Means of Nonhierarchical Processes

We introduce a fully nonhierarchical network growing mechanism, that furthermore does not impose explicit preferential attachment rules. The growing procedure produces a graph featuring power-law degree and clustering distributions, and manifesting slightly disassortative degree-degree correlations. The rigorous rate equations for the evolution of the degree distribution and for the conditional degree-degree probability are derived.
DNA Methylation in Cosmc Promoter Region and Aberrantly Glycosylated IgA1 Associated with Pediatric IgA Nephropathy

IgA nephropathy (IgAN) is one of the most common glomerular diseases leading to end-stage renal failure. Elevation of aberrantly glycosylated IgA1 is a key feature of it. The expression of the specific molecular chaperone of core1ß1, 3galactosyl transferase (Cosmc) is known to be reduced in IgAN. We aimed to investigate whether the methylation of CpG islands of Cosmc gene promoter region could act as a possible mechanism responsible for down-regulation of Cosmc and related higher secretion of aberrantly glycosylated IgA1in lymphocytes from children with IgA nephropathy. Three groups were included: IgAN children (n = 26), other renal diseases (n = 11) and healthy children (n = 13). B-lymphocytes were isolated and cultured, treated or not with IL-4 or 5-Aza-2’-deoxycytidine (AZA). The levels of DNA methylation of Cosmc promotor region were not significantly different between the lymphocytes of the three children populations (P = 0.113), but there were significant differences between IgAN lymphocytes and lymphocytes of the other two children populations after IL-4 (P<0.0001) or AZA (P<0.0001). Cosmc mRNA expression was low in IgAN lymphocytes compared to the other two groups (P<0.0001). The level of aberrantly glycosylated IgA1 was markedly higher in IgAN group compared to the other groups (P<0.0001). After treatment with IL-4, the levels of Cosmc DNA methylation and aberrantly glycosylated IgA1 in IgAN lymphocytes were remarkably higher than the other two groups (P<0.0001) with more markedly decreased Cosmc mRNA content (P<0.0001). After treatment with AZA, the levels in IgAN lymphocytes were decreased, but was still remarkably higher than the other two groups (P<0.0001), while Cosmc mRNA content in IgAN lymphocytes were more markedly increased than the other two groups (P<0.0001). The alteration of DNA methylation by IL-4 or AZA specifically correlates in IgAN lymphocytes with alterations in Cosmc mRNA expression and with the level of aberrantly glycosylated IgA1 (r = −0.948, r = 0. 707). Our results suggested that hypermethylation of Cosmc promoter region could be a key mechanism for the reduction of Cosmc mRNA expression in IgAN lymphocytes with associated increase in aberrantly glycosylated IgA1.
Phubbed and Alone: Phone Snubbing, Social Exclusion, and Attachment to Social Media

Preoccupation with our cellphones has irrevocably changed how we interact with others. Despite many advantages of smartphones, they may undermine both our in-person relationships and our well-being. As the first to investigate the impact of phubbing (phone-snubbing), the present research contributes to our nascent understanding of the role of smartphones in consumer behavior and well-being. We demonstrate the harmful effects of phubbing, revealing that phubbed individuals experience a sense of social exclusion, which leads to a heightened need for attention and results in individuals attaching to social media in hopes of regaining a sense of inclusion. Although the stated purpose of technology like smartphones is to help us connect with others, in this particular instance, it does not. Ironically, the very technology that was designed to bring humans closer together has isolated us from these very same people.
Distributed versus Localist Representations: Evidence from a Study of Item Consistency in a Case of Classical Anomia

Models of word production and comprehension can be split into two broad classes: localist and distributed. In localist architectures each word within the lexicon is represented by a single unit. The distributed approach, on the other hand, encodes each lexical item as a pattern of activation across a set of shared units. If we assume that the localist representations are more than a convenient shorthand for distributed representations at the neuroanatomical level, it should be possible to find patients who, after brain injury, have lost specific words from their premorbid vocabulary. Following a closed head injury, JS had severe word-finding difficulties with no measurable semantic impairment nor did he make phonological errors in naming. Cueing with an initial phoneme proved relatively ineffective. JS showed a high degree of item consistency across three administrations of two tests of naming to confrontation. This consistency could not be predicted from a linear combination of psycholinguistic variables but the distribution fitted a stochastic model in which it is assumed that a proportion of items have become consistently unavailable. Further evidence is presented which suggests that these items are not, in fact, lost but rather have a very low probability of retrieval. Given phonemic cueing of sufficient length, or delayed repetition priming from a written word, the consistently unnamed items were produced by JS. Additional data is reported which seems to support a distributed model of speech production. JS's naming accuracy for one set of pictures was found to predict his performance on a second set of items only when the names of the pictures were both semantically and phonologically related (e.g., cat-rat). There was no association for pairs of pictures if they were only semantically (e.g., cat-dog) or phonologically related (e.g., cat-cap). It is argued that JS's data are best described in terms of a graded, non-linear, distributed model of speech production.
Cytological Findings of the Micropapillary Variant of Urothelial Carcinoma: A Comparison with Typical High-Grade Urothelial Carcinoma

Background Micropapillary variant of urothelial carcinoma (MPUC) showed distinct pathologic features and aggressive behavior. The cytologic findings of MPUC are still indistinct. In this study, we evaluated the cytological findings of MPUC compared with those of high-grade urothelial carcinoma (HGUC). Methods The voided urine cytology of 8 cases of MPUC and 8 cases of HGUC was reviewed. Following cytological parameters were evaluated: cellularity, background, number of small, tight papillary clusters, small acinar structure, scattered single cells, cytoplasmic features, nuclear-to-cytoplasmic ratio, nuclear pleomorphism, nuclear membrane irregularity, hyperchromasia, chromatin pattern and nucleoli. Results Compared to that of HGUC, cytology of MPUC showed large numbers of small, tight papillary clusters, small acinar structure, few numbers of single cells, and hyperchromatic nuclei. Other parameters were similar between the two groups; both groups showed similar cellularity, dense or vacuolated cytoplasm, moderate to severe nuclear pleomorphism, irregular nuclear membrane, coarse granular chromatin, and small and prominent nucleoli. Conclusions The urine cytology of MPUCs showed smaller and tighter papillary cell clusters, more small acinar structures, fewer numbers of scattered single cells, and more hyperchromatic nuclei than that of HGUC. These features can help to distinguish MPUC and HGUC and offer an early cytological diagnosis of MPUC.
Knowledge about human sexuality among under graduate medical students

In India, talking about sex is taboo. Little is known about the knowledge, attitude, and sexual behavior of young adults. 1 This study is carried out with the purpose of exploring knowledge about human sexuality among undergraduate medical students.Recent studies indicate that sexual health topics are often not broached by physicians within the medical encounter. Among the barriers to communication about sexual health are: lack of provider comfort and knowledge; provider biases about sexual issues; fear of offending patients; and time constraints within the typical patient encounter. 2-4 Recent national and global initiatives have drawn attention to the importance of sexual health to individuals’ well-being. These initiatives advocate enhancement of efforts to address this underrepresented topic in health professions curricula. Medical school training can be an important means of promoting the appropriate and effective management of sexual functioning problems. 6-8 Currently, a significant gap in knowledge regarding existing sexual health components of undergraduate medical education exists. 9-11 Only a few studies have addressed the attitudes and values that may underlie physicians’ medical practices, especially those related to emotionally sensitive issues such as sexuality. 5,12.
A train-the-trainer design for green ambassadors in an environmental education programme on plastic waste recycling

ABSTRACT To educate a sustainable future, a train-the-trainer (TTT) approach was adopted to train student teachers (STs) from a teacher education institute to be green ambassadors (GAs) in an environmental education (EE) programme with the aim of promoting plastic waste recycling among primary school pupils. The design of the TTT course for the GAs not only focused on the input of subject matter knowledge, but also on pedagogical practices to help them develop pedagogical content knowledge (PCK) for effective teaching. The GAs were interviewed to find out their PCK understanding after the programme. The features related to PCK identified in this study can be used to inform TTT design, which is important for educators in the future development of GAs in EE programmes.
Potenciais evocados auditivos de estado estável em crianças com perdas auditivas cocleares*** Auditory steady-state response in children with cochler hearing loss

Background: auditory steady-state response (ASSR) is indicated as a promising technique in the assessment of the hearing status of children. Aim: to investigate the level of agreement between the results of the ASSR and the visual reinforcement audiometry (VRA) in a group of children, thus examining the clinical applicability of this technique in hearing assessment of children. Method: participants were 14 children with ages between 4 and 36 months (mean 16 months) with the diagnosis of cochlear hearing loss. The ASSR was recorded in the frequencies of 0.5, 1, 2 and 4kHz for multiple simultaneous stimulation and the results were compared with the visual reinforcement audiometry (VRA). Results: the intraclass correlation coefficients between ASSR and VRA were 0.90, 0.93, 0.93 and 0.89 respectively for the frequencies of 0.5, 1, 2 and 4kHz, indicating a strong correlation between the techniques. Conclusion: the ASSR can provide accurate information to support the selection of hearing aids for children when it is not possible to perform the VRA.
Multilingual Training of Crosslingual Word Embeddings

Crosslingual word embeddings represent lexical items from different languages using the same vector space, enabling crosslingual transfer. Most prior work constructs embeddings for a pair of languages, with English on one side. We investigate methods for building high quality crosslingual word embeddings for many languages in a unified vector space.In this way, we can exploit and combine strength of many languages. We obtained high performance on bilingual lexicon induction, monolingual similarity and crosslingual document classification tasks.
A Decrease in Anandamide Signaling Contributes to the Maintenance of Cutaneous Mechanical Hyperalgesia in a Model of Bone Cancer Pain

Tumors in bone are associated with pain in humans. Data generated in a murine model of bone cancer pain suggest that a disturbance of local endocannabinoid signaling contributes to the pain. When tumors formed after injection of osteolytic fibrosarcoma cells into the calcaneus bone of mice, cutaneous mechanical hyperalgesia was associated with a decrease in the level of anandamide (AEA) in plantar paw skin ipsilateral to tumors. The decrease in AEA occurred in conjunction with increased degradation of AEA by fatty acid amide hydrolase (FAAH). Intraplantar injection of AEA reduced the hyperalgesia, and intraplantar injection of URB597, an inhibitor of FAAH, increased the local level of AEA and also reduced hyperalgesia. An increase in FAAH mRNA and enzyme activity in dorsal root ganglia (DRG) L3–L5 ipsilateral to the affected paw suggests DRG neurons contribute to the increased FAAH activity in skin in tumor-bearing mice. Importantly, the anti-hyperalgesic effects of AEA and URB597 were blocked by a CB1 receptor antagonist. Increased expression of CB1 receptors by DRG neurons ipsilateral to tumor-bearing limbs may contribute to the anti-hyperalgesic effect of elevated AEA levels. Furthermore, CB1 receptor protein-immunoreactivity as well as inhibitory effects of AEA and URB597 on the depolarization-evoked Ca2+ transient were increased in small DRG neurons cocultured with fibrosarcoma cells indicating that fibrosarcoma cells are sufficient to evoke phenotypic changes in AEA signaling in DRG neurons. Together, the data provide evidence that manipulation of peripheral endocannabinoid signaling is a promising strategy for the management of bone cancer pain.
The Partial Line Digraph Technique in the Design of Large Interconnection Networks

The following problem arises in the design of some interconnection networks for distributed systems. Namely, to construct digraphs with given maximum out-degree, reduced diameter, easy routing, good connectivity, and good expandability. To this end, a method based on the concept of partial line digraph is presented. This proposal, which turns out to be a generalization of the so-called line digraph technique, allows digraphs that satisfy all the above-mentioned requirements to be obtained. In particular, it is shown that the partial line digraphs of Kautz digraphs solve the (d, N) digraph problem, i.e. to minimize the diameter D in a digraph of maximum out-degree d and number of vertices N, for any N in the range d/sup D-1/+d/sup D-2/+. +1 >
Forecasting and combining competing models of exchange rate determination

This article investigates the out-of-sample forecast performance of a set of competing models of exchange rate determination. We compare standard linear models with models that characterize the relationship between exchange rate and the underlying fundamentals by nonlinear dynamics. Linear models tend to outperform at short forecast horizons especially when deviations from long-term equilibrium are small. In contrast, nonlinear models with more elaborate mean-reverting components dominate at longer horizons especially when deviations from long-term equilibrium are large. The results also suggest that combining different forecasting procedures generally produces more accurate forecasts than can be attained from a single model.
Expert by experience research as grounding for social work education

Abstract This article is based on an investigation that involves five experts by experience in the field of mental health and eight students of social work. Both groups investigated the experiences of people with mental ill-health living in group homes. The article identifies the advantages if the researchers are expert by experience and the epistemological shift produced by the inclusion of people with the lived experience. Expert by experience research is a challenge to both experts by experience and for social work practice since it promotes the basic principle of social work as the science of doing. This study was based on the assertion that the real integration of theory and practice will not come from a rigid body of knowledge, but from the humility to learn from experts by experience.