Miracle-dz/UniFAR-FTUs huggingface dataset:
Near real‐time radar interferometry of the Mw 7.1 Hector Mine Earthquake

The Hector Mine Earthquake (Mw 7.1, 16 October 1999) ruptured 45 km of previously mapped and unmapped faults in the Mojave Desert. The ERS‐2 satellite imaged the Mojave Desert on 15 September and again on 20 October, just 4 days after the earthquake. Using a newly‐developed ground station we acquired both passes and were able to form an interferogram within 20 hours of the second overflight. Estimates of slip along the main rupture are 1–2 meters greater than slip derived from geological mapping. The gradient of the interferometric phase reveals an interesting pattern of triggered slip on adjacent faults as well as a 30 mm deep sink hole along Interstate 40.
Shared energy storage management for renewable energy integration in smart grid

Energy storage systems (ESSs) are essential components of the future smart grid to smooth out the fluctuating output of renewable energy generators. However, installing large number of ESSs for individual energy consumers may not be practically implementable, due to both the space limitation and high investment cost. As a result, in this paper, we study the energy management problem of multiple users with renewable energy sources and a single shared ESS. To solve this problem, we propose an algorithm that jointly optimizes the energy charged/discharged to/from the shared ESS given a profit coefficient set that specifies the desired proportion of the total profit allocated to each user, subject to practical constraints of the system. We conduct simulations based on the real data from California, US, and show that the shared ESS can potentially increase the total profit of all users by 10% over the case that users own individual small-scale ESSs with no energy sharing.
The presence of pneumococcal bacteremia does not influence clinical outcomes in patients with community-acquired pneumonia: results from the Community-Acquired Pneumonia Organization (CAPO) International Cohort study.

BACKGROUND It remains unknown whether pneumococcal bacteremia increases the risk of poor outcomes in hospitalized patients with community-acquired pneumonia (CAP). The objective of this study was to investigate whether the presence of pneumococcal bacteremia influences the clinical outcomes of hospitalized patients with CAP. METHODS We performed secondary analyses of the Community-Acquired Pneumonia Organization database of hospitalized patients with CAP and pneumococcal bacteremia, and patients with CAP and negative blood culture findings. To identify the effect of pneumococcal bacteremia on patient outcomes, we modeled all-cause mortality and CAP-related mortality using logistic regression analysis, and time to clinical stability and length of hospital stay using Cox proportional hazards models. RESULTS We studied 125 subjects with pneumococcal bacteremic CAP and 1,847 subjects with nonbacteremic CAP. The multivariable regression analysis revealed a lack of association of pneumococcal bacteremic CAP and time to clinical stability (hazard ratio, 0.87; 95% confidence interval [CI], 0.7 to 1.1; p = 0.25), length of hospital stay (hazard ratio, 1.14; 95% CI, 0.91 to 1.43; p = 0.25), all-cause mortality (odds ratio [OR], 0.68; 95% CI, 0.36 to 1.3; p = 0.25), and CAP-related mortality (OR, 0.86; 95% CI, 0.35 to 2.06; p = 0.73). CONCLUSIONS Pneumococcal bacteremia does not increase the risk of poor outcomes in patients with CAP. Factors related to severity of disease are confounders of the association between pneumococcal bacteremia and poor outcomes. This study indicates that the presence of pneumococcal bacteremia by itself should not be a contraindication for deescalation of therapy in clinically stable hospitalized patients with CAP.
Border detection in dermoscopy images using statistical region merging

Background: As a result of advances in skin imaging technology and the development of suitable image processing techniques, during the last decade, there has been a significant increase of interest in the computer‐aided diagnosis of melanoma. Automated border detection is one of the most important steps in this procedure, because the accuracy of the subsequent steps crucially depends on it.
NOC-Out: Microarchitecting a Scale-Out Processor

Scale-out server workloads benefit from many-core processor organizations that enable high throughput thanks to abundant request-level parallelism. A key characteristic of these workloads is the large instruction footprint that exceeds the capacity of private caches. While a shared last-level cache (LLC) can capture the instruction working set, it necessitates a low-latency interconnect fabric to minimize the core stall time on instruction fetches serviced by the LLC. Many-core processors with a mesh interconnect sacrifice performance on scale-out workloads due to NOC-induced delays. Low-diameter topologies can overcome the performance limitations of meshes through rich inter-node connectivity, but at a high area expense. To address the drawbacks of existing designs, this work introduces NOC-Out -- a many-core processor organization that affords low LLC access delays at a small area cost. NOC-Out is tuned to accommodate the bilateral core-to-cache access pattern, characterized by minimal coherence activity and lack of inter-core communication, that is dominant in scale-out workloads. Optimizing for the bilateral access pattern, NOC-Out segregates cores and LLC banks into distinct network regions and reduces costly network connectivity by eliminating the majority of inter-core links. NOC-Out further simplifies the interconnect through the use of low-complexity tree-based topologies. A detailed evaluation targeting a 64-core CMP and a set of scale-out workloads reveals that NOC-Out improves system performance by 17% and reduces network area by 28% over a tiled mesh-based design. Compared to a design with a richly-connected flattened butterfly topology, NOC-Out reduces network area by 9x while matching the performance.
Patient perspectives on primary health care in rural communities: effects of geography on access, continuity and efficiency.

INTRODUCTION Examining how to deliver primary health care (PHC) services and increase their accessibility (regardless of geographic location) from the patient's perspective is needed. We conducted seven focus groups with people (n = 50) living in rural communities, in British Columbia, Canada, as they reflected on priorities for and use of PHC. METHODS In addition to discussing their priorities for PHC services, participants completed a brief questionnaire designed to collect information regarding socio-demographics, health status and utilization of primary healthcare providers. Descriptive statistics were obtained from questionnaire data. Focus group data were coded using an evaluation framework specifically developed for PHC; a thematic content analysis was then conducted on the coded data. RESULTS In total, 80% of participants had been patients of the same provider for more than one year and had an average of two chronic conditions. Participants described the challenges posed by geographical location in terms of: (1) making tradeoffs; (2) management, information, and relationship continuity of care; and (3) efficiency with health care delivery. Additional out-of-pocket expenses were associated with traveling to regional centers for health services. Those living in rural communities, especially people needing additional health services to manage their health problems, made tradeoffs between their safety of having to travel during times of poor road conditions and having their healthcare needs met. CONCLUSION Challenges to timely access to a regular healthcare provider, continuity of information and management of people's chronic disease conditions, and linkages to specialist services and diagnostic tests pose challenges for those living in rural communities. The geographic location of rural communities compounds the extent to which these people are able to access timely and continuous PHC.
Clusters of Trends Detection in Microblogging: Simple Natural Language Processing vs Hashtags – Which is More Informative?

In this paper we introduce the initial proposition and evaluation of the method that enables detection of clusters of trends among microblogging posts gathered from a given social graph. By the cluster of trends we mean the trending words that are popular among same group of people and which describes their common interests. The information about shared interests of group of people in the social network is very important for business. Knowing it we can for example perform directed advertising campaign aimed at single community of people. We validate our approach on large datasets that contains 22 030 252 tweets posted by 20 130 followers of the world-known actress. We found that clusters of trends detection in microblogging with simple natural language processing (namely lemmatization) did not give any valuable information for business. For the other side hashtags frequency filtering and probability conditional probabilities graph clustering resulted in valuable informative about structure of interest in social network.
Is case management effective in reducing the risk of unplanned hospital admissions for older people? A systematic review and meta-analysis.

BACKGROUND Case management is a collaborative practice involving coordination of care by a range of health professionals, both within the community and at the interface of primary and secondary care. It has been promoted as a way of reducing unplanned admissions in older people. OBJECTIVE The objective was to systematically review evidence from randomized controlled trials regarding the effectiveness of case management in reducing the risk of unplanned hospital admissions in older people. METHODS Eighteen databases were searched from inception to June 2010. Relevant websites were searched with key words and reference lists of included studies checked. A risk-of-bias tool was used to assess included studies and data extraction performed using customized tables. The primary outcome of interest was enumeration of unplanned hospital admission or readmissions. RESULTS Eleven trials of case management in the older population were included. Risk of bias was generally low. Six were trials of hospital-initiated case management. Three were suitable for meta-analysis, of which two showed a reduction in unplanned admissions. Overall, there was no statistically significant reduction in unplanned admissions [relative rate: 0.71 (95% confidence interval, CI: 0.49 to 1.03)]. Three trials reported reduced length of stay. Five trials were of community-initiated case management. None showed a reduction in unplanned admissions. Three were suitable for meta-analysis [mean difference in unplanned admissions: 0.05 (95% CI: -0.04 to 0.15)]. CONCLUSIONS The identified trials included a range of case management interventions. Nine of the 11 trials showed no reduction of unplanned hospital admissions with case management compared with the same with usual care.
Pretreatment with oral contraceptive pills to identify poor responders that may benefit from rLH supplementation during GnRH-antagonist treatment for IVF: A pilot perspective study proposal

Controlled ovarian stimulation, using a gonadotrophin-releasing hormone (GnRH) antagonist protocol, is a potential treatment option for women with a low response to other fertility treatments as it appears to be at least as effective as GnRH agonists (long protocol). However, previous studies have indicated that the administration of GnRH antagonist may cause an excessive reduction in endogenous luteinizing hormone (LH) levels. The use of recombinant LH (rLH) supplementation during ovarian stimulation is controversial. The present article proposes a future study focused on women aged ≥40 years old, with the aim of identifying patients who are poor responders to GnRH-antagonist treatment that may benefit from rLH supplementation. We hypothesize that patients with suppressed hypothalamic-pituitary-axis activity may benefit from rLH supplementation, as GnRH-antagonist administration has the potential to induce a marked reduction in LH levels in such patients compared with that in patients that exhibit a regular recovery following the administration of oral contraceptive pills (OCPs). Furthermore, patients with hyper-responsive hypothalamic-pituitary-axis activity may be affected by ‘low-gonadotropin-responsiveness’, similar to that observed in patients with any mutation in the follicle-stimulating hormone (FSH) receptor, who are known to benefit from rLH supplementation. The proposed pilot study would include 120 women who are predicted to be poor responders to GnRH-antagonist treatment. All subjects will be allocated at random (using 2:1 computerized randomization) into two study groups: Group A (OCP-treated) and group B (control). For all patients, the serum values of FSH, LH and 17β estradiol (E2) will be detected on day 3 of the menstrual cycle preceding OCP treatment (baseline) and at day 4 following OCP treatment. The Δ-variation from baseline levels for all markers, the FSH/LH ratio and the E2/FSH ratio will be determined. Δ-variation from the baseline of the FSH and LH values will be used to further categorize group A patients into subgroups A1–4, based on respective quartile numbers (Q1–4). Patients admitted to each of the four subgroups A1–4, based on their FSH quartile, will be selected at random to receive rLH supplementation (ratio, 1:1) during ovarian stimulation. If the resulting data are able to identify women that may benefit from rLH supplementation during ovarian stimulation, a large part of inconclusive evidence regarding rLH supplementation will be clarified. If patients supplemented with rLH (according to abnormal recovery of hypothalamic-pituitary-axis activity after OCP treatment) exhibit an improved ovarian response during in vitro fertilization (IVF) and subsequent pregnancy rate, the pre-IVF OCP test could be adopted as a useful tool for improving the success rate of assisted reproductive technologies in poorly-responding patients.
Age-group differences in speech identification despite matched audiometrically normal hearing: contributions from auditory temporal processing and cognition

Hearing loss with increasing age adversely affects the ability to understand speech, an effect that results partly from reduced audibility. The aims of this study were to establish whether aging reduces speech intelligibility for listeners with normal audiograms, and, if so, to assess the relative contributions of auditory temporal and cognitive processing. Twenty-one older normal-hearing (ONH; 60–79 years) participants with bilateral audiometric thresholds ≤ 20 dB HL at 0.125–6 kHz were matched to nine young (YNH; 18–27 years) participants in terms of mean audiograms, years of education, and performance IQ. Measures included: (1) identification of consonants in quiet and in noise that was unmodulated or modulated at 5 or 80 Hz; (2) identification of sentences in quiet and in co-located or spatially separated two-talker babble; (3) detection of modulation of the temporal envelope (TE) at frequencies 5–180 Hz; (4) monaural and binaural sensitivity to temporal fine structure (TFS); (5) various cognitive tests. Speech identification was worse for ONH than YNH participants in all types of background. This deficit was not reflected in self-ratings of hearing ability. Modulation masking release (the improvement in speech identification obtained by amplitude modulating a noise background) and spatial masking release (the benefit obtained from spatially separating masker and target speech) were not affected by age. Sensitivity to TE and TFS was lower for ONH than YNH participants, and was correlated positively with speech-in-noise (SiN) identification. Many cognitive abilities were lower for ONH than YNH participants, and generally were correlated positively with SiN identification scores. The best predictors of the intelligibility of SiN were composite measures of cognition and TFS sensitivity. These results suggest that declines in speech perception in older persons are partly caused by cognitive and perceptual changes separate from age-related changes in audiometric sensitivity.
Panpulmonate transcriptomes reveal candidate genes involved in the adaptation to freshwater and terrestrial habitats in gastropods

Background The conquest of the land from aquatic habitats is a fascinating evolutionary event that happened multiple times in different phyla. Mollusks are among the organisms that successfully invaded the non-marine realm, resulting in the radiation of terrestrial panpulmonate gastropods. We compared transcriptomes from panpulmonates to study the selective pressures that modeled the transitions from marine into freshwater and terrestrial realms in this molluscan lineage. Results De novo assembly of six panpulmonate transcriptomes resulted in 55,000 - 97,000 predicted open reading frames, of which 9 - 14% were functionally annotated. Adding published transcriptomes, we predicted 791 ortholog clusters shared among fifteen panpulmonate species, resulting in 702 amino acid and 736 codon-wise alignments. The branch-site test of positive selection applied to the codon-wise alignments showed twenty-eight genes under positive selection in the freshwater lineages and seven in the terrestrial lineages. Gene ontology categories of these candidate genes include actin assembly, transport of glucose, and the tyrosine metabolism in the terrestrial lineages; and, DNA repair, metabolism of xenobiotics, mitochondrial electron transport, and ribosome biogenesis in the freshwater lineages. Conclusions We identified candidate genes representing processes that may have played a key role during the water-to-land transition in Panpulmonata. These genes were involved in energy metabolism and gas-exchange surface development in the terrestrial lineages and in the response to the abiotic stress factors (UV radiation, osmotic pressure, xenobiotics) in the freshwater lineages. Our study expands the knowledge of possible adaptive signatures in genes and metabolic pathways related to the invasion of non-marine habitats in invertebrates.
Low birthweight and Type 2 diabetes: a study on 11 162 Swedish twins.

BACKGROUND To investigate the association between low birthweight and diabetes in a population-based Swedish twin sample. Method A cohort of 11 162 same-sexed Swedish twins born between 1906 and 1958 was used in order to investigate the risk of developing Type 2 diabetes between and within twin pairs by utilizing random effects linear models. RESULTS Between pairs there was a significant increase in risk of developing Type 2 diabetes for a 1-kg increase in their mean birthweight (odds ratio [OR] = 2.13; P < 0.01), adjusted for age, sex, body mass index (BMI), and smoking status. The corresponding risk within pair was 2.03 (P = 0.07) for monozygotic twins and 1.15 (P = 0.71) for dizygotic twins. The test of the heterogeneity of the within and between effects showed no significant difference between the estimates. CONCLUSIONS The study suggests that reduced fetal growth increase the risk of Type 2 diabetes due to an in utero programming effect possibly caused by intrauterine malnutrition. However, it does not exclude the possibility of a common genetic mechanism.
Complex interplay between β-catenin signalling and Notch effectors in intestinal tumorigenesis

Aims The activation of β-catenin signalling is a key step in intestinal tumorigenesis. Interplay between the β-catenin and Notch pathways during tumorigenesis has been reported, but the mechanisms involved and the role of Notch remain unclear. Methods Notch status was analysed by studying expression of the Notch effector Hes1 and Notch ligands/receptors in human colorectal cancer (CRC) and mouse models of Apc mutation. A genetic approach was used, deleting the Apc and RBP-J or Atoh1 genes in murine intestine. CRC cell lines were used to analyse the control of Hes1 and Atoh1 by β-catenin signalling. Results Notch signalling was found to be activated downstream from β-catenin. It was rapidly induced and maintained throughout tumorigenesis. Hes1 induction was mediated by β-catenin and resulted from both the induction of the Notch ligand/receptor and Notch-independent control of the Hes1 promoter by β-catenin. Surprisingly, the strong phenotype of unrestricted proliferation and impaired differentiation induced by acute Apc deletion in the intestine was not rescued by conditional Notch inactivation. Hyperactivation of β-catenin signalling overrode the forced differention induced by Notch inhibition, through the downregulation of Atoh1, a key secretory determinant factor downstream of Notch. This process involves glycogen synthase kinase 3 β (GSK3β) and proteasome-mediated degradation. The restoration of Atoh1 expression in CRC cell lines displaying β-catenin activation was sufficient to increase goblet cell differentiation, whereas genetic ablation of Atoh1 greatly increased tumour formation in Apc mutant mice. Conclusion Notch signalling is a downstream target of β-catenin hyperactivation in intestinal tumorigenesis. However, its inhibition had no tumour suppressor effect in the context of acute β-catenin activation probably due to the downregulation of Atoh1. This finding calls into question the use of γ-secretase inhibitors for the treatment of CRC and suggests that the restoration of Atoh1 expression in CRC should be considered as a therapeutic approach.
Education, migration, and job satisfaction: The regional returns of human capital in the EU. Bruges European Economic Research (BEER) Papers 1/November 2004

The paper looks at the link between human capital and regional economic performance in the EU. Using indicators of educational stock, the matching of educational supply and labour demand, and migration extracted from the European Community Household Panel (ECHP), it identifies that the economic performance of European regions over the last few years is generally associated with differences in human capital endowment. However, and in contrast to previous studies, the results highlight that factors such as the matching of educational supply and local labour needs, job satisfaction, and migration may have a stronger connection to economic performance than the traditional measures of educational stock.
Estimating Relative Fitness in Viral Competition Experiments

ABSTRACT The relative fitness of viral variants has previously been defined as the slope of the logarithmic ratio of the genotype or phenotype frequencies in time plots of pairwise competition experiments. Developing mathematical models for such experiments by employing the conventional coefficient of selection s, we demonstrate that this logarithmic ratio gives the fitness difference, rather than the relative fitness. This fitness difference remains proportional to the actual replication rate realized in the particular experimental setup and hence cannot be extrapolated to other situations. Conversely, the conventional relative fitness (1 + s) should be more generic. We develop an approach to compute the generic relative fitness in conventional competition experiments. This involves an estimation of the total viral replication during the experiment and requires an estimate of the average lifetime of productively infected cells. The novel approach is illustrated by estimating the relative fitness, i.e., the relative replication rate, of a set of zidovudine-resistant human immunodeficiency virus type 1 variants. A tool for calculating the relative fitness from observed changes in viral load and genotype (or phenotype) frequencies is publically available on the website athttp://www-binf.bio. uu.nl/∼rdb/fitness.html .