Miracle-dz/UniFAR-FTUs huggingface dataset:
Antioxidant Activities of Melittis melissophyllum L. (Lamiaceae)

Extracts of Melittis melissophyllum leaves in ether, chloroform, ethyl acetate, n-butanol and water were evaporated to dryness and dissolved in 50% ethanol to make 10% (w/v) solutions. The potential protective action of the extracts was assessed by the corresponding in vitro and in vivo tests. In the in vitro experiments extracts were tested as potential scavengers of free radicals (DPPH, O2·−, NO, and OH radicals), as well as inhibitors of liposomal peroxidation (LPx). The results obtained show that all extracts (exept n-BuOH extract) are good scavengers of radicals and reduce LPx intensity in liposomes, which points to their protective (antioxidant) activity. In vivo experiments were concerned with antioxidant systems (activities of GSHPx, GSHR, Px, CAT, XOD, GSH content and intensity of LPx) in liver homogenate and blood-hemolysate of experimental animals after their treatment with extracts of M. melissophyllum leaves, or in combination with CCl4. On the basis of the results obtained it can be concluded that the examined extracts have protective (antioxidative) effect and this antioxidative behaviour is more pronounced in liver than in blood-hemolysate. The reason is probably the fact that liver contains other enzymatic systems, which can also participate in the antioxidative mechanism. Of all the extracts the H2O one showed the highest protective activity.
Orientation domain diversity in macaque area V2

Single orientation domains in primary (V1) and second (V2) visual cortical areas are known to encode the orientation of visual contours. However, the visual world contains multiple and complex contour types. How do these domains handle such complexity? Using optical imaging methods, we have examined orientation response to two types of contours: real (luminance-defined) and illusory (inferred). We find that, unlike area V1, there are multiple types of orientation domain in V2. These include “real only” domains, “higher-order” domains (which respond to an orientation whether real or illusory), and other domains with nonmatching real/illusory orientation preference. We suggest that this plurality of orientation domains in V2 enables the complexities of local and global contour extraction.
Developing New Understandings of Independence and Autonomy in the Personalised Relationship

The personalisation of adult social care has the potential to create support that is individualised, and it is the reality of this support relationship that forms the basis of this article. To date, there have been few studies that focus on the association between care users and their workers. Here, we consider research from a Ph.D. study that allows for comparison between two sets of relationships: between disabled adults and homecare workers employed by a local authority, and between disabled adults using direct payments to employ their own personal assistants. The research pays attention to the meanings attached to the concepts of independence and autonomy, with a model of autonomy applied to aid clarity and develop our understanding of complexities in support relationships. The research uses a grounded theory approach with qualitative interviews of matched samples of respondents, providing new evidence about the personalised relationship. Based on the research, we argue that direct employment of support workers appears to facilitate greater autonomy for disabled adults than traditional homecare relationships. However, the research goes on to suggest that greater autonomy for disabled adults may have a downside for support workers.
The role of propeller aerodynamics in the model of a quadrotor UAV

We study models of a quadrotor UAV. These models include various aerodynamic effects of the propellers and their interactions with the motion of the rigid body of the UAV. Two main assumptions are formulated: the twisting of the propellers is such that the local angle of attack is constant along the blades in stationary flight, and, secondly, that the local induced velocity is also constant along the blades. Under these assumptions (which correspond to an optimal hovering rotor), we conclude that the flexibility of the propellers plays an important role in the dynamics of the UAV (including the effects of the vertical location of the center of gravity), and that it is interesting to account for it when designing a closed loop controller.
Children classified as controlling at age six: Evidence of disorganized representational strategies and aggression at home and at school

Abstract The purpose of this study was to determine whether children classified as controlling in attachment differ from children classified into the traditional Ainsworth attachment categories in their symbolic representations of attachment and level of behavior problems. Sixty-nine middle-class kindergarten children and their mothers participated in a laboratory separation and reunion. Children enacted doll-play stories about attachment-related themes. A four-group representation classification scheme was developed from the doll-play transcripts of 27 children. Mothers (n = 44) completed Achenbach's Child Behavior Checklist and teachers (n = 40) completed a 30-item inventory of classroom behavior. Results showed significant agreement between the representational system and Main and Cassidy's classification system (1988) for children's reunion behavior. The doll-play of controlling children was characterized by themes of catastrophe and helplessness or by complete inhibition of play and suggested disorganization of representational processes. Controlling children also were described by mothers and teachers as significantly more aggressive than other children. The results validate the distinction between the controlling and traditional classification groups and suggest that controlling children are at risk for behavioral maladaptation at home and at school.
Examining the Effect of External Factors and Context-Dependent Beliefs of Teachers in the Use of ICT in Teaching

Research into teachers' attitudes, beliefs, competence, and inhibitions in relation to their use of technology may provide answers to a series of questions from administrators that relate to teachers' classroom implementation of Information and Communication Technology. The theory of planned behavior is a useful model for providing a framework for predicting and explaining behaviors and a guideline for intervention purposes that would produce effective behavioral change. In this study, the elaborated theory of planned behavior model, Information and Communication Technology Use Model was used as a specific theoretical framework for the purpose of identifying factors that can be used for designing intervention or mounting professional development workshops for Information and Communication Technology implementation that will effectively induce change in teachers' behavior.
Post-recurrence survival of patients with non-small-cell lung cancer after curative resection with or without induction/adjuvant chemotherapy.

OBJECTIVES Recently, the prognosis of patients with non-small-cell lung cancer (NSCLC) has improved, thanks to the standardization of adjuvant chemotherapy and the introduction of molecular-targeted drugs, notably epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors and other new anti-cancer agents. However, the survival characteristics and prognosis of patients with recurrent NSCLC after curative resection are not well understood. METHODS Of the 430 consecutive patients with NSCLC who underwent complete surgical resection at our institution between January 2004 and July 2011, we included 76 patients with recurrence whose post-recurrence treatment and outcome could be confirmed. We then retrospectively evaluated the effect of prognostic factors on post-recurrence survival. RESULTS There were 50 men and 26 women, and the median age at recurrence was 74.5 years. The median time from surgical resection to recurrence was 12.7 months. Thirty-eight of the 76 (50%) patients underwent multimodality treatment with surgery and preoperative and/or postoperative chemotherapy as their initial treatment. For recurrence, systemic chemotherapy was administered to 64 (84%) patients, and the disease control rate for first-line chemotherapy was 55%. The 1- and 2-year post-recurrence survival rates were 68.3 and 45.8%, respectively, and the median post-recurrence survival time was 17.7 months. Six independent prognostic factors were identified: wild-type EGFR, no adjuvant chemotherapy for the primary lung cancer, age ≥ 80 years at recurrence, a poor Eastern Cooperative Oncology Group performance status at recurrence, symptomatic at recurrence and no systemic chemotherapy for recurrence, which significantly decreased the post-recurrence survival. CONCLUSIONS The prognosis of patients with NSCLC recurrence after surgery is currently improving. Our results suggested two new prognostic factors, adjuvant chemotherapy and EGFR mutations, neither of which have been previously reported. Treatment strategies for postoperative recurrence should be established based on a more detailed subdivision of factors, such as histology and molecular markers, in the future.
Explaining Perceived Impacts of All-Inclusive Resorts through Community Attachment

Antalya, with its high percentage of all-inclusive resorts (hereafter abbreviated AIR), is a prime tourist destination in Turkey. The purpose of this study was to examine the interrelationships‖ between‖ residents’‖ attitudes‖ about‖ their‖attachment to their local community and attitudes about AIR impacts. A survey was conducted in four key districts in Antalya (based on the concentration of AIRs in the areas): the Antalya city center, Kemer, Serik and Manavgat, yielding a robust sample (n = 660). Exploratory factor analysis of the Perceptions of All-Inclusive Resorts Scale revealed four unique factors (e.g., three focused on negative impacts and one on positive impacts). The study adopted the Community Attachment (CA) Scale and Perceptions of All-Inclusive Resorts (PAIR) as conceptual frameworks. ‖The‖study’s‖findings‖demonstrated‖that‖highly‖attached residents tend to perceive negative impacts of AIR. Findings provide empirical support for the employment of the community attachment framework within studies concerning AIR perceptions. Implications are described and directions for future research are discussed
International Journal of Soft Computing and Engineering

379 AbstractHydropower from the river is one of the best renewable sources. Hydropower source is predictable compared to wind or solar energy. For generation of electricity using the kinetic energy of natural water resources, Savonius rotor is one of the best types of turbine. The Savonius turbine is more popular as wind turbine. However, in present work, attempt is made for use of Savonius rotor as hydro turbine application. A 3D computational model built and analyzed using a Computational Fluid Dynamic (CFD) analysis using ANSYS. The effect of overlap ratio is investigated for performance enhancement Savonius turbine. In present investigation three different overlap ratios, 0.0, 0.1 and 0.2 are studied, at different angular speeds of rotor. It is found that the maximum torque can be obtained at overlap ratio of 0.2.
Behavioral / Systems / Cognitive Functional Magnetic Resonance Imaging Activity during the Gradual Acquisition and Expression of Paired-Associate Memory

Jon R. Law,1 Marci A. Flanery,1 Sylvia Wirth,2 Marianna Yanike,2 Anne C. Smith,3 Loren M. Frank,4 Wendy A. Suzuki,2 Emery N. Brown,5,6 and Craig E. L. Stark1 1Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, Maryland 21218, 2Center for Neural Science, New York University, New York, New York 10003, 3Department of Anesthesiology and Pain Medicine, University of California, Davis, California 95616, 4W. M. Keck Center for Integrative Neuroscience, University of California, San Francisco, San Francisco, California 94143, 5Neuroscience Statistics Research Laboratory, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, Massachusetts 02114, and 6Division of Health Sciences and Technology, Harvard Medical School/Massachusetts Institute of Technology, Cambridge, Massachusetts 02139
Clinical and Electrocardiographic Evaluation of Sickle-Cell Anaemia Patients with Pulmonary Hypertension

Pulmonary hypertension is an emerging complication of sickle cell anaemia with associated increased risk of mortality. In order to evaluate the clinical and electrocardiographic findings in adult sickle-cell patients with pulmonary hypertension, a cross sectional study was conducted on sixty two sickle cell anaemia patients and sixty two age and sex matched normal controls. Elevated pulmonary artery pressures (PAP), defined by PAP ≥ 30 mm Hg on echocardiography, was demonstrated in 41.9% of patients with sickle cell anaemia and in 3.2% of the controls; χ 2 = 26.571, P < 0.001. Right ventricular hypertrophy, increased P-wave duration, QTc interval, and QTc dispersion were significantly associated with pulmonary hypertension. Significant correlation was found between mean PAP and (1) Frequency of crisis (Spearman correlation = 0.320; P = 0.011), (2) body mass index (Pearson's correlation = −0.297; P = 0.019), and (3) QTc interval (Pearson's correlation 0.261; P = 0.040). Pulmonary hypertension in adult sickle anaemia patients is associated with electrocardiographic evidence of right ventricular hypertrophy, and correlates significantly with frequency of vaso-occlusive crisis, and QTc interval. The observations by this study tend to suggest that these parameters could be useful for early detection and prevention of pulmonary hypertension in patients with sickle cell anaemia.
IL‐21 enhances SOCS gene expression and inhibits LPS‐induced cytokine production in human monocyte‐derived dendritic cells

Dendritic cells (DCs) play an important role in innate and adaptive immune responses. In addition to their phagocytic activity, DCs present foreign antigens to naïve T cells and regulate the development of adaptive immune responses. Upon contact with DCs, activated T cells produce large quantities of cytokines such as interferon‐γ (IFN‐γ) and interleukin (IL)‐21, which have important immunoregulatory functions. Here, we have analyzed the effect of IL‐21 and IFN‐γ on lipopolysaccharide (LPS)‐induced maturation and cytokine production of human monocyte‐derived DCs. IL‐21 and IFN‐γ receptor genes were expressed in high levels in immature DCs. Pretreatment of immature DCs with IL‐21 inhibited LPS‐stimulated DC maturation and expression of CD86 and human leukocyte antigen class II (HLAII). IL‐21 pretreatment also dramatically reduced LPS‐stimulated production of tumor necrosis factor α, IL‐12, CC chemokine ligand 5 (CCL5), and CXC chemokine ligand 10 (CXCL10) but not that of CXCL8. In contrast, IFN‐γ had a positive feedback effect on immature DCs, and it enhanced LPS‐induced DC maturation and the production of cytokines. IL‐21 weakly induced the expression Toll‐like receptor 4 (TLR4) and translation initiation region (TIR) domain‐containing adaptor protein (TIRAP) genes, whereas the expression of TIR domain‐containing adaptor‐inducing IFN‐β (TRIF), myeloid differentiation (MyD88) 88 factor, or TRIF‐related adaptor molecule (TRAM) genes remained unchanged. However, IL‐21 strongly stimulated the expression of suppressor of cytokine signaling (SOCS)‐1 and SOCS‐3 genes. SOCS are known to suppress DC functions and interfere with TLR4 signaling. Our results demonstrate that IL‐21, a cytokine produced by activated T cells, can directly inhibit the activation and cytokine production of myeloid DCs, providing a negative feedback loop between DCs and T lymphocytes.
Physical, sexual and emotional violence against women: a general practice‐based prevalence study

3. YipJ. Microalbuminuria collaborative studygroup,UnitedKingdom. Risk factors for development of microalbuminuria in insulindependentdiabeticpatients: a cohortstudy.BMJ1993; 306: 1235-1239. 4. Gall M-A, Barch-Johnsen K, Hougaard P, et al. Albuminuria andpoorglycemiccontrolpredictmortality in NiDDM. Diabetes 1995;44: 1303-1309. 5. Pedersen MM,SchmitzA, Pedersen EB,et al.Acuteand longterm renaleffectsof angiotensin convertingenzymeinhibition in normotensive, normoalbuminuric insulin dependentdiabetic patients.Diabetic Med 1988;5: 562-569. 0
The effects of performance expectations on total compensation of division i-fbs head coaches

The literature examining executive and upper management compensation has looked at a variety of factors. Within sport, coaches are equivalent to these positions with one of the major factors determining total compensation being on-field performance. However, little is known on how expectations of on-field performance compared to actual performance affect compensation. The purpose of this study is to analyze the effect of performance expectations on Division I - Football Bowl Subdivision head football coaches’ total compensation. Using data from 2006 to 2013, compensation increases when on-field performance expectations are exceeded. The impact of an additional on-field win relative to performance expectations is between 5.0 and 5.5% in terms of additional compensation. However, no statistically significant effect exists when comparing coaches at automatic qualifying versus non-automatic qualifying schools. In addition, off-field measures of performance as well as individual and university characteristics affect total compensation.
AIS Electronic

Interrupted work environments are commonplace in today’s organizations. In addition, organizational work is increasingly performed using some form of computer support. Consequently, there is a need to examine how the design and delivery of information systems can help to mitigate the potentially deleterious effects of interruptions on decision-maker performance. This paper reports the results of two experiments that investigate the influence of interruptions on different types of tasks and the ability of information presentation formats to alleviate them. Interruptions were found to facilitate performance on simple tasks, while inhibiting performance on more complex tasks. Furthermore, there was some evidence that the frequency of interruptions and similarity of the content of the primary and interruption tasks also negatively influenced performance. Finally, interruptions moderated the relationship between information presentation format and specific types of tasks.
Borel superrigidity and the classification problem for the torsion-free abelian groups of finite rank

In 1937, Baer solved the classification problem for the torsion-free abelian groups of rank 1. Since then, despite the efforts of many mathematicians, no satisfactory solution has been found of the classification problem for the torsion-free abelian groups of rank n . 2. So it is natural to ask whether the classification problem for the higher rank groups is genuinely difficult. In this article, I will explain how this question can be partially answered, using ideas from descriptive set theory and Zimmer�fs superrigidity theory.
Neuropharmacological Actions of Metformin in Stroke

Increasing epidemiologic evidence suggests that metformin, a well-established AMPK activator and the most favorable first-line anti-diabetic drug, reduces stroke incidence and severity. However, the mechanism for this remains unclear. Moreover, previous experimental studies have reported controversial results about the effects of metformin on stroke outcomes during the acute phase. However, recent studies have consistently suggested that AMPK-mediated microglia/macrophage polarization and angioneurogenesis may play essential roles in metformin-promoted, long-term functional recovery following stroke. The present review summarizes the neuropharmacological actions of metformin in experimental stroke with an emphasis on the recent findings that the cell-specific effects and duration of AMPK activation are critical to the effects of metformin on stroke outcomes.
The AS87_04050 Gene Is Involved in Bacterial Lipopolysaccharide Biosynthesis and Pathogenicity of Riemerella anatipestifer

Riemerella anatipestifer is reported worldwide as a cause of septicemic and exudative diseases of domestic ducks. In this study, we identified a mutant strain RA2640 by Tn4351 transposon mutagenesis, in which the AS87_04050 gene was inactivated by insertion of the transposon. Southern blot analysis indicated that only one insertion was found in the genome of the mutant strain RA2640. SDS-PAGE followed by silver staining showed that the lipopolysaccharide (LPS) pattern of mutant strain RA2640 was different from its wild-type strain Yb2, suggesting the LPS was defected. In addition, the phenotype of the mutant strain RA2640 was changed to rough-type, evident by altered colony morphology, autoaggregation ability and crystal violet staining characteristics. Bacterial LPS is a key factor in virulence as well as in both innate and acquired host responses to infection. The rough-type mutant strain RA2640 showed higher sensitivity to antibiotics, disinfectants and normal duck serum, and higher capability of adherence and invasion to Vero cells, compared to its wild-type strain Yb2. Moreover, the mutant strain RA2640 lost the agglutination ability of its wild-type strain Yb2 to R. anatipestifer serotype 2 positive sera, suggesting that the O-antigen is defected. Animal experiments indicated that the virulence of the mutant strain RA2640 was attenuated by more than 100,000-fold, compared to its wild-type strain Yb2. These results suggested that the AS87_04050 gene in R. anatipestifer is associated with the LPS biosynthesis and bacterial pathogenicity.
Study of Risky Behaviors in Adolescents with Psychiatric Disorders Attending a Mental Health Department

Background: Risky behaviors can have damaging consequences in physical or mental health in adolescents, even more causing the majority of adolescent morbidity and mortality. In line with the Problem behavior theory, the balance between protective and risk factors will define the proneness for problem behaviors. The purpose of this study was to assess the prevalence of risky behaviors in adolescents with psychiatric disorders and to assess the possible predictive role of the presence of a psychiatric diagnosis, age and gender. Methods: A questionnaire was developed, to assess environmental factors and risky behaviors in adolescents with psychiatric disorders who attended the Department of Child and Adolescent Psychiatry and Psychology in a general public hospital in Barcelona. Results: It was observed that almost half of the sample presented at least a second diagnose. It should be noted that more than half of the sample had had feelings of hopelessness and that almost half presented suicidal thoughts. A logistic regression analysis showed that, except for going on a restrictive diet and doing physical exercise to control or lose weight, all problem behaviors were predicted by constitutional and environmental factors, rather than by having a psychiatric diagnosis. Conclusion: Most of the risky behaviors were mainly predicted by environmental factors, such as having both parents present, restructured family, friends consume marijuana, peers’ opinion more valued than parents’ opinion or retaking a school year, and diagnostic categories had a low influence on the different risky behaviors. Out of these findings, it is evident that the Problem behavior theory was confirmed in a clinical sample and that there is need for screening tools on a regular base, to detect problem behaviors, protective and risk factors in each adolescent’s case,to do an improved prevention and intervention, promoting protective factors related to adolescent’s values and expectations, encouraging parental controls and support and boosting peer models of healthy behaviors.