Miracle-dz/UniFAR-FTUs huggingface dataset:
Validation of the ASAR Global Monitoring Mode Soil Moisture Product Using the NAFE'05 Data Set

The Advanced Synthetic Aperture Radar (ASAR) Global Monitoring (GM) mode offers an opportunity for global soil moisture (SM) monitoring at much finer spatial resolution than that provided by the currently operational Advanced Microwave Scanning Radiometer for the Earth Observing System and future planned missions such as Soil Moisture and Ocean Salinity and Soil Moisture Active Passive. Considering the difficulties in modeling the complex soil-vegetation scattering mechanisms and the great need of ancillary data for microwave backscatter SM inversion, algorithms based on temporal change are currently the best method to examine SM variability. This paper evaluates the spatial sensitivity of the ASAR GM surface SM product derived using the temporal change detection methodology developed by the Vienna University of Technology. This evaluation is made for an area in southeastern Australia using data from the National Airborne Field Experiment 2005. The spatial evaluation is made using three different types of SM data (station, field, and airborne) across several different scales (1-25 km). Results confirmed the expected better agreement when using point (R station = 0.75) data as compared to spatial (R PLMR, 1 km = 0.4) data. While the aircraft-ASAR GM correlation values at 1-km resolution were low, they significantly improved when averaged to 5 km (R PLMR, 5 km = 0.67) or coarser. Consequently, this assessment shows the ASAR GM potential for monitoring SM when averaged to a spatial resolution of at least 5 km.
Bias and population structure in the actuation of sound change

Why do human languages change at some times, and not others? We address this longstanding question from a computational perspective, focusing on the case of sound change. Sound change arises from the pronunciation variability ubiquitous in every speech community, but most such variability does not lead to change. Hence, an adequate model must allow for stability as well as change. Existing theories of sound change tend to emphasize factors at the level of individual learners promoting one outcome or the other, such as channel bias (which favors change) or inductive bias (which favors stability). Here, we consider how the interaction of these biases can lead to both stability and change in a population setting. We find that population structure itself can act as a source of stability, but that both stability and change are possible only when both types of bias are active, suggesting that it is possible to understand why sound change occurs at some times and not others as the population-level result of the interplay between forces promoting each outcome in individual speakers. In addition, if it is assumed that learners learn from two or more teachers, the transition from stability to change is marked by a phase transition, consistent with the abrupt transitions seen in many empirical cases of sound change. The predictions of multiple-teacher models thus match empirical cases of sound change better than the predictions of single-teacher models, underscoring the importance of modeling language change in a population setting.
Pure neural leprosy: Diagnostic value of the polymerase chain reaction

Pure neural leprosy (PNL) is often difficult to diagnose when acid‐fast bacilli (AFB) cannot be detected. We undertook the present study to evaluate use of the polymerase chain reaction (PCR) in diagnosing PNL. Fifty‐eight patients (41 men and 17 women) suspected of pure neural leprosy (PNL) were examined. Patients were classified as borderline tuberculoid (BT, 40 cases) and polar tuberculoid (TT, 18 cases) types. Nerve biopsy was performed and was positive for AFB in 20 patients (all BT patients), i.e., 34.5% of total cases. DNA was extracted from the nerve biopsy samples and amplified using PCR for a specific repeated sequence of DNA from Mycobacterium leprae. PCR analysis was positive in the nerve samples from 29 patients (50%), 27 of the BT type, and 2 of the TT type patients. Further, PCR analysis was positive in 14 of 38 cases that were negative for AFB by nerve biopsy, of which 12 were of the BT type and 2 the TT type. PCR analysis proved to be a useful method to investigate pure neural leprosy, enabling confirmation of the diagnosis in more than a third of the cases that were negative for AFB by nerve biopsy. Muscle Nerve 2006
SurvivalHyporesponsiveness and Prolong Allograft Express Fas Ligand Induce Donor-Specific Dendritic Cells Genetically Engineered to

Polarization of an immune response toward tolerance or immunity is dictated by the interactions between T cells and dendritic cells (DC), which in turn are modulated by the expression of distinct cell surface molecules, and the cytokine milieu in which these interactions are taking place. Genetic modiﬁcation of DC with genes coding for speciﬁc immunoregulatory cell surface molecules and cytokines offers the potential of inhibiting immune responses by selectively targeting Ag-speciﬁc T cells. In this study, the immunomodulatory effects of transfecting murine bone marrow-derived DC with Fas ligand (FasL) were investigated. In this study, we show that FasL transfection of DC markedly augmented their capacity to induce apoptosis of Fas 1 cells. FasL-trans-fected DC inhibited allogeneic MLR in vitro, and induced hyporesponsiveness to alloantigen in vivo. The induction of hyporesponsiveness was Ag speciﬁc and was dependent on the interaction between FasL on DC and Fas on T cells. Finally, we show that transfusion of FasL-DC signiﬁcantly prolonged the survival of fully MHC-mismatched vascularized cardiac allografts. Our ﬁnd-ings suggest that DC transduced with FasL may facilitate the development of Ag-speciﬁc unresponsiveness for the prevention of organ rejection. Moreover, they highlight the potential of genetically engineering DC to express other genes that affect immune responses. The Journal of Immunology, 2000, 164: 161–167.
The Proteomic Landscape of the Suprachiasmatic Nucleus Clock Reveals Large-Scale Coordination of Key Biological Processes

The suprachiasmatic nucleus (SCN) acts as the central clock to coordinate circadian oscillations in mammalian behavior, physiology and gene expression. Despite our knowledge of the circadian transcriptome of the SCN, how it impacts genome-wide protein expression is not well understood. Here, we interrogated the murine SCN proteome across the circadian cycle using SILAC-based quantitative mass spectrometry. Of the 2112 proteins that were accurately quantified, 20% (421 proteins) displayed a time-of-day-dependent expression profile. Within this time-of-day proteome, 11% (48 proteins) were further defined as circadian based on a sinusoidal expression pattern with a ∼24 h period. Nine circadianly expressed proteins exhibited 24 h rhythms at the transcript level, with an average time lag that exceeded 8 h. A substantial proportion of the time-of-day proteome exhibited abrupt fluctuations at the anticipated light-to-dark and dark-to-light transitions, and was enriched for proteins involved in several key biological pathways, most notably, mitochondrial oxidative phosphorylation. Additionally, predicted targets of miR-133ab were enriched in specific hierarchical clusters and were inversely correlated with miR133ab expression in the SCN. These insights into the proteomic landscape of the SCN will facilitate a more integrative understanding of cellular control within the SCN clock.
Artemin promotes functional long-distance axonal regeneration to the brainstem after dorsal root crush

Significance Recovery after a spinal cord injury requires that axons regenerate and reconnect with their original targets. Here we report that after interruption of sensory axons in dorsal roots, systemic treatment with a naturally occurring growth factor, artemin (ARTN), promotes regeneration of these axons 3–4 cm away from their original target region in the brainstem, where they reestablish functional connections. In contrast to earlier studies, we also find that GDNF family receptor, a known receptor for ARTN, is expressed on both myelinated and unmyelinated sensory neurons, consistent with ARTN’s ability to promote regeneration of large and small sensory neurons. Recovery after a spinal cord injury often requires that axons restore synaptic connectivity with denervated targets several centimeters from the site of injury. Here we report that systemic artemin (ARTN) treatment promotes the regeneration of sensory axons to the brainstem after brachial dorsal root crush in adult rats. ARTN not only stimulates robust regeneration of large, myelinated sensory axons to the brainstem, but also promotes functional reinnervation of the appropriate target region, the cuneate nucleus. ARTN signals primarily through the RET tyrosine kinase, an interaction that requires the nonsignaling coreceptor GDNF family receptor (GFRα3). Previous studies reported limited GFRα3 expression on large sensory neurons, but our findings demonstrate that ARTN promotes robust regeneration of large, myelinated sensory afferents. Using a cell sorting technique, we demonstrate that GFRα3 expression is similar in myelinated and unmyelinated adult sensory neurons, suggesting that ARTN likely induces long-distance regeneration by binding GFRα3 and RET. Although ARTN is delivered for just 2 wk, regeneration to the brainstem requires more than 3 mo, suggesting that brief trophic support may initiate intrinsic growth programs that remain active until targets are reached. Given its ability to promote targeted functional regeneration to the brainstem, ARTN may represent a promising therapy for restoring sensory function after spinal cord injury.
Neural Substrates for Semantic Memory of Familiar Songs: Is There an Interface between Lyrics and Melodies?

Findings on song perception and song production have increasingly suggested that common but partially distinct neural networks exist for processing lyrics and melody. However, the neural substrates of song recognition remain to be investigated. The purpose of this study was to examine the neural substrates involved in the accessing “song lexicon” as corresponding to a representational system that might provide links between the musical and phonological lexicons using positron emission tomography (PET). We exposed participants to auditory stimuli consisting of familiar and unfamiliar songs presented in three ways: sung lyrics (song), sung lyrics on a single pitch (lyrics), and the sung syllable ‘la’ on original pitches (melody). The auditory stimuli were designed to have equivalent familiarity to participants, and they were recorded at exactly the same tempo. Eleven right-handed nonmusicians participated in four conditions: three familiarity decision tasks using song, lyrics, and melody and a sound type decision task (control) that was designed to engage perceptual and prelexical processing but not lexical processing. The contrasts (familiarity decision tasks versus control) showed no common areas of activation between lyrics and melody. This result indicates that essentially separate neural networks exist in semantic memory for the verbal and melodic processing of familiar songs. Verbal lexical processing recruited the left fusiform gyrus and the left inferior occipital gyrus, whereas melodic lexical processing engaged the right middle temporal sulcus and the bilateral temporo-occipital cortices. Moreover, we found that song specifically activated the left posterior inferior temporal cortex, which may serve as an interface between verbal and musical representations in order to facilitate song recognition.
Waterfall City (Johannesburg): Privatized Urbanism in Extremis

Located halfway between Johannesburg and Pretoria, the mixed-use megadevelopment called Waterfall City is a master-planned, holistically designed, urban enclave built entirely from scratch on 2200 ha of vacant land. This expansive city-building project at Waterfall City combines a hypermodernist stress on ‘smart’ growth, cutting-edge technologies, and state-of-the-art infrastructure with the New Urbanist focus on mixed-use facilities, a human-scale built environment, and pedestrian-friendly precincts. By performing all the conventional functions expected of a municipal administration, the real estate developers at Waterfall City have effectively replaced public authority with private management and control. With its private governance structures and ‘go-it-alone’ mentality, Waterfall City is an exemplary expression of a privately managed municipality that falls within the broad tradition of company towns, treaty concessions, free ports, and independent city-states. Apart from its sheer size and scale and administrative autonomy, the outstanding feature of Waterfall City is its unique blend of stern religious conformity (grounded in a traditional interpretation of Islamic principles) combined with a forward-looking commitment to private enterprise and consumerist consumption.
Email lists and participatory democracy in the European Social Forum

The Global Justice Movement burst into the public consciousness in Seattle in late 1999. Since then ‘almost every summit of a transnational (economic) organization has led to street mobilizations’ (van Aelst and Walgrave, 2004: 102), attracting thousands of activists and extensive media coverage. Targets include international economic institutions, such as the World Bank or the International Monetary Fund, which are considered as the main regulators of the neoliberal globalization project. Apart from protests and demonstrations, global justice activists have also launched another type of convergence space, the social forums. These ‘have largely eclipsed mass protests as the primary vehicles where diverse movement networks converge across urban space to make themselves visible, generate affective attachments, and communicate alternatives and critiques’ (Juris, 2005: 255). According to its Charter of Principles, the World Social Forum (WSF) constitutes ‘an open meeting place’ that is meant to operate as a ‘public square’ for actors to meet and network (Whitaker, 2004: 113). The WSF was founded in 2001 as an alternative to the ‘World Economic Forum’ (WEF), an independent organization consisting of the 1000 leading businesses in the world (Patomäki and Teivanen, 2004: 145). The WSF idea met with such success that, since its inception, regional or even national and local social forums have swiftly started to crop up around the world, in Asia, Europe and the Americas. The first European Social Forum (ESF) took place in Florence in October 2002, drawing around 60,000
A portrait of benchmark school: How a school produces high achievement in students who previously failed.

This is a case study of Benchmark School, which educates 6- to 15-year-olds with a history of school failure. Grounded theory methodology was employed to generate a theory about how the school promotes achievement. Many elements potentially promoting academic achievement were identified, including ones informed by psychological theory and research (e.g., evidence-based literacy instructional practices, strategies instruction, conceptually focused content instruction, many mechanisms to motivate students) but also, selective admissions, human resources (i.e., well-trained teachers, supportive parents, skilled counselors), small class size, and a supportive physical context. The theory that emerges is that many elements must be articulated to remediate struggling elementary students, although some are more important than others.
The Assessment of Present-Moment Awareness and Acceptance

The purpose of this project was to develop a bidimensional measure of mindfulness to assess its two key components: present-moment awareness and acceptance. The development and psychometric validation of the Philadelphia Mindfulness Scale is described, and data are reported from expert raters, two nonclinical samples (n = 204 and 559), and three clinical samples including mixed psychiatric outpatients (n = 52), eating disorder inpatients (n = 30), and student counseling center outpatients (n = 78). Exploratory and confirmatory factor analyses support a two-factor solution, corresponding to the two constituent components of the construct. Good internal consistency was demonstrated, and relationships with other constructs were largely as expected. As predicted, significant differences were found between the nonclinical and clinical samples in levels of awareness and acceptance. The awareness and acceptance subscales were not correlated, suggesting that these two constructs can be examined independently. Potential theoretical and applied uses of the measure are discussed.
Type A behavior and its relation to personality variables in Swedish male and female university students

A questionnaire based on the Jenkins Activity Survey (JAS), given to 181 male and 280 female Swedish university students, showed that females had significantly higher Type A scores than males. Three factors were extracted by factor analysis, two of which, “speed and impatience” and “hard-driving”, corresponded to two of the factors obtained by JAS in an American population of employed men (Zyzanski & Jenkins, 1970). The third factor was tentatively termed “engagement-involvement”. Twelve male and 12 female subjects from opposite ends of the distribution were compared in terms of 22 personality variables measured by questionnaires. It was found that Type A subjects of both sexes scored higher on scales measuring anxiety-proneness, aggression-hostility, extraversion and neuroticism.
A Comparative Study of Osteogenic Differentiation Human Induced Pluripotent Stem Cells and Adipose Tissue Derived Mesenchymal Stem Cells

Objective Human induced pluripotent stem cells (iPSCs) have been shown to have promising capacity for stem cell therapy and tissue engineering applications. Therefore, it is essential to compare the ability of these cells with the commonly used mesenchymal stem cells (MSC) for bone tissue engineering in vitro. Materials and Methods In this experimental study, the biological behavior and osteo- genic capacity of the iPSCs were compared with MSCs isolated from human adipose tissue (AT-MSCs) using 3-(4,5-di-methylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, Alizarin red staining, alkaline phosphatase (ALP) activity measurements, calcium content assay and common osteogenic-related genes. Data were reported as the mean ± SD. One-way analysis of variance (ANOVA) was used to compare the results. A p value of less than 0.05 was considered statistically significant. Results There was a significant difference between the rate of proliferation of the two types of stem cells; iPSCs showed increased proliferation compared to AT-MSCs. During osteogenic differentiation, ALP activity and mineralization were demonstrated to be significantly higher in iPSCs. Although AT-MSCs expressed higher levels of Runx2, iPSCs expressed higher levels of osteonection and osteocalcin during differentiation. Conclusion iPSCs showed a higher capacity for osteogenic differentiation and hold promising potential for bone tissue engineering and cell therapy applications.
Moderating effects of work-based support on the relationship between job insecurity and its consequences.

Abstract This study examined the moderating effects of work-based support (i.e. support provided by work colleagues and supervisor) on the relationship between job insecurity and (1) job dissatisfaction, and (2) non-compliant job behaviours. Data were collected through a questionnaire sent by post to MBA alumni of a large university in the USA (n = 306). The results of moderated regression analysis showed that supervisor support and work colleague support significantly moderated the relationship between job insecurity and the two outcomes examined. These findings suggest that support derived from others at the workplace can contribute significantly in buffering individuals against job dissatisfaction and non-compliant job behaviours when their job security is at stake. The processes through which work-based support operates in moderating the relationship between job insecurity and its outcomes are discussed.
Luminescent Dual Sensors Reveal Extracellular pH-Gradients and Hypoxia on Chronic Wounds That Disrupt Epidermal Repair

Wound repair is a quiescent mechanism to restore barriers in multicellular organisms upon injury. In chronic wounds, however, this program prematurely stalls. It is known that patterns of extracellular signals within the wound fluid are crucial to healing. Extracellular pH (pHe) is precisely regulated and potentially important in signaling within wounds due to its diverse cellular effects. Additionally, sufficient oxygenation is a prerequisite for cell proliferation and protein synthesis during tissue repair. It was, however, impossible to study these parameters in vivo due to the lack of imaging tools. Here, we present luminescent biocompatible sensor foils for dual imaging of pHe and oxygenation in vivo. To visualize pHe and oxygen, we used time-domain dual lifetime referencing (tdDLR) and luminescence lifetime imaging (LLI), respectively. With these dual sensors, we discovered centripetally increasing pHe-gradients on human chronic wound surfaces. In a therapeutic approach, we identify pHe-gradients as pivotal governors of cell proliferation and migration, and show that these pHe-gradients disrupt epidermal barrier repair, thus wound closure. Parallel oxygen imaging also revealed marked hypoxia, albeit with no correlating oxygen partial pressure (pO2)-gradient. This highlights the distinct role of pHe-gradients in perturbed healing. We also found that pHe-gradients on chronic wounds of humans are predominantly generated via centrifugally increasing pHe-regulatory Na+/H+-exchanger-1 (NHE1)-expression. We show that the modification of pHe on chronic wound surfaces poses a promising strategy to improve healing. The study has broad implications for cell science where spatial pHe-variations play key roles, e.g. in tumor growth. Furthermore, the novel dual sensors presented herein can be used to visualize pHe and oxygenation in various biomedical fields.
Effects of the Copy-Cover-Compare Strategy on Acquisition, Maintenance, and Generalization of Spelling Sight Words for Elementary Students With Attention Deficit/Hyperactivity Disorder

Students with attention deficit/hyperactivity disorder (ADHD) often struggle with spelling. Research shows this population benefits from self-management interventions, structured practice opportunities, and immediate feedback—all components of the copy-cover-compare strategy. This empirical investigation used a multiple-baseline experimental design to determine the effects of the copy-cover-compare strategy on acquisition, generalization, and maintenance of spelling words for four students with ADHD in Grades 1 through 3. Results showed a functional relation between copy-cover-compare and mastery, maintenance, and generalization of three sets of spelling words for each student. Limitations, implications for practice, and suggestions for future research are discussed.
‘I Would Have Been Able to Hear What They Think’: Tensions in Achieving Restorative Outcomes in the English Youth Justice System

This article presents findings from in-depth, semi-structured interviews with young offenders and Victim Liaison Officers, and observations of youth offender panels. It focuses upon the attitudes of young offenders towards victims and their reactions to the prospect of meeting the victim of their offending face-to-face as part of their referral order. Significant tensions between the aspirations of restorative justice and the reality of present practice in the English system are examined. The article proposes change in relation to justice disposals for incipient young offenders, particularly in relation to the ubiquitous use of restorative justice approaches for this group.