Miracle-dz/UniFAR-FTUs huggingface dataset:
Normalization of impaired coronary circulation in hypertrophied rat hearts.

We tested the hypothesis that impaired coronary autoregulation, decreased flow reserve, and diminished reactive hyperemic response in hypertrophied hearts with coronary arterial hypertension may be reversible after relief of pressure overload. In 4-week ascending aortic banded rats, in vivo peak systolic left ventricular pressure increased to 178 +/- 8 mm Hg (103 +/- 6 mm Hg in sham-operated control group). This increased pressure produced myocardial hypertrophy, and the left ventricular weight/body weight ratio was 46% above that of the control group. After the rats were killed, the coronary perfusion pressure-flow relations were obtained during resting conditions and maximal vasodilation after a 40-second period of ischemia in beating but nonworking isolated hearts perfused with Tyrode's solution with bovine red blood cells and albumin. In hearts from control rats, coronary autoregulation (i.e., a slight decrease in flow with reduction of pressure) was observed in the range of 50-100 mm Hg of perfusion pressure. A pronounced reactive hyperemic response was observed: a peak flow/resting flow ratio of 2.9 +/- 0.1 and a repayment ratio of 1.7 +/- 0.2 at 100 mm Hg of perfusion pressure. In hearts of banded rats the resting pressure-flow relation was rectilinear in the range of 25-175 mm Hg of perfusion pressure. Flow reserve and the time of reactive hyperemia to one half peak flow decreased at 50, 100, and 150 mm Hg of perfusion pressure compared with values in control rat hearts. Four weeks after debanding, peak systolic left ventricular pressure and cardiac hypertrophy had normalized. The impaired autoregulation, decreased flow reserve, and diminished reactive hyperemic response had completely reversed. (ABSTRACT TRUNCATED AT 250 WORDS)
The Parents' Perception of Nursing Support in their Neonatal Intensive Care Unit (NICU) Experience

NICU is an environment that has many challenges in information receiving and understanding. The infants that are cared for might have serious and complex medical problems. For Parents the NICU experience is filled with stress, fear, sadness, guilt and shock of having a sick baby in NICU. The aim of this research was to explore and describe parents' experience when their infant is admitted to the NICU. And assess their perception of nursing support of information provision and according to their emotional feelings. This study was undertaken at Neonatal Intensive Care Unit in King Abdulaziz Medical City (KAMC), Jeddah, Saudi Arabia which is part of National Guard Health Affairs (NGHA) organization in the kingdom. The study utilized a self-report questionnaire with likert scale measurement and telephone interview with closed questions. One hundred and four parents agree to be the part of study and provided their consent to include their children in the study. The majority of respondents were mothers (76%), the remaining (24%) from the total sample were Fathers. All their infants have been admitted to the NICU at 2014. Many parents did not able to receive enough information easily from the unit; most of them found the information by nurses was difficult to understand. The majority of parent's perceived high stress and anxiety level according to this information. Also, Most Parents was not agreed about the nurses' support towards their emotional feeling and care. Additional finding indicate that a decrease in support level being associated with an increase in stress and anxiety level. In order to provide a high level of support and decrease the level of stress, there is a need for developing support strategies. One strategy is through a technology to develop an automatic daily summary for parent.
Análisis factorial confirmatorio de la escala valencia de actitudes y creencias hacia la hipnosis (versión cliente revisada), en una muestra española

Title: Confirmatory factor analysis of the valencia scale of attitudes and be- liefs toward hypnosis (revised client version), with a spanish sample. Abstract: Several approaches to hypnosis have highlighted the importance of attitudes and beliefs on it to promote hypnotic responses, their power to predict the efficacy of interventions that include hypnosis, as well as to generate or prevent iatrogenic reactions in patients. The goal of this study is to investigate the new variation of the Valencia Scale of Attitudes and Beliefs toward Hypnosis Client version, written in Castilian. The scale was analyzed using confirmatory methodology to obtain its factor structure and psychometric properties, in order to confirm the results of previous ex- ploratory and confirmatory research, with samples from different coun- tries. A sample of 1.678 Spanish university students was used this time. Data show an eight factors structure (Fear, Memory, Help, Control, Col- laboration, Interest, Magic and Marginal), and an appropriate internal con- sistency and test-retest reliability. Results are similar to those found in pre- vious exploratory and confirmatory factorial analysis conducted in different countries.
Efficacy and Safety of a Fixed Combination of Tramadol and Paracetamol (Acetaminophen) as Pain Therapy Within Palliative Medicine

Goal: The goal of the research was to determine the efficacy of a fixed combination of tramadol and paracetamol (acetaminophen) in the treatment of pain of patients with the advanced stage of cancer. Material and methods: A prospective study was conducted at the Center for Palliative Care, University Clinical Center Tuzla, Bosnia and Herzegovina, from January 1st to December 31st 2013. A total of 353 patients who were treated with a fixed combination of tramadol and acetaminophen (37.5 mg and 325 mg) at the initial dosage 3x1 tablet (112.5 mg tramadol and 975 mg acetaminophen) for pain intensity 4, up to 4x2 tablets (300 mg of tramadol and 2600 mg paracetamol) for pain intensity 7 and 8. If the patient during previous day has two or more pain episodes that required a “rescue dose” of tramadol, increased was the dose of fixed combination tramadol and acetaminophen to a maximum of 8 tablets daily (300 mg of tramadol and 2600 mg paracetamol). Statistical analysis was performed by biomedical software MedCalc for Windows version 9.4. 2.0. The difference was considered significant for P<0.05. Results: The average duration of treatment with a fixed combination tramadol and acetaminophen was 57 days (13-330 days). Already after 24 hours of treatment the average pain score was significantly lower (p<0.0001) compared to the admission day [5.00 (4:00 to 8:00) during the first days versus 2.00 (1:00 to 7:00) during the second day of treatment]. The average dose of the fixed combination tramadol and acetaminophen tablets was 4.8 ± 1.8 (180 mg of tramadol and 1560 mg paracetamol). Side effects, in the treatment of pain with a fixed combination tramadol and acetaminophen, were found in 29.18% of patients, with a predominance of nausea and vomiting. Conclusion: Fixed combination of tramadol and acetaminophen can be used as an effective combination in the treatment of chronic cancer pain, with frequent dose evaluation and mild side effects.
Multicast capacity of multihop cognitive networks

In this paper, we study the capacity of cognitive networks. We focus on the network model consisting of two overlapping ad hoc networks, called the primary ad hoc network (PaN) and secondary ad hoc network (SaN), respectively. PaN and SaN operate on the same space and spectrum. For PaN (or SaN resp.) we assume that primary (or secondary resp.) nodes are placed according to a Poisson point process of intensity n (or m resp.) over a unit square region. We randomly choose ns (or ms resp.) nodes as the sources of multicast sessions in PaN (or SaN resp.), and for each primary source vp (or secondary source vs), we pick uniformly at random nd primary nodes (or md secondary nodes) as the destinations of vp (or vs). Above all, we assume that PaN can adopt the optimal protocol in terms of the throughput. Our main work is to design the multicast strategy for SaN by which it can achieve the optimal throughput, without any negative impact on the throughput for PaN in order sense. Specifically, depending on nd and n, we choose the optimal strategy for PaN from two candidates called percolation strategy and connectivity strategy, respectively. Subsequently, we design the corresponding throughput-optimal strategy for SaN. We further derive the regimes for n, nd, m and md where the throughputs for PaN and SaN can simultaneously achieve the upper bound of their capacities asymptotically.
When Parents Relinquish Care: Informal Support Networks of Older People with Intellectual Disability

Adults with intellectual disability lack the two key providers of informal support in later life, children and a spouse. This qualitative study examined the informal support networks of 62 older people with intellectual disability who had left parental care after mid-life. Semi-structured interviews with multiple informants were used to collect data about their supportive relationships. Informal networks were found to be small, dense and dominated by family members. A striking feature was the existence of a ‘key person’ who combined frequent contact, strong commitment and performance of a range of instrumental tasks. Key people were predominantly siblings but also included more distant relatives and friends. These findings indicate that, for this subgroup of older people, normative family roles such as ‘protector’ and ‘facilitator’ (Sussman, 1985) were fulfilled by informal network members despite the absence of spouses or children.
The German multi‐centre study on smoking‐related behavior—description of a population‐based case‐control study

Tobacco smoking is a major risk factor for most of the diseases leading in mortality. Nicotine dependence (ND), which sustains regular smoking, is now acknowledged to be under substantial genetic control with some environmental contribution. At present, however, genetic studies on ND are mostly conducted in populations that have been poorly characterized with regard to ND‐related phenotypes for the simple reason that the respective populations were not primarily collected to study ND. The German multi‐centre study ‘Genetics of Nicotine Dependence and Neurobiological Phenotypes’, which is funded by the German Research Foundation (Deutsche Forschungsgemeinschaft, DFG) as part of the Priority Program (Schwerpunktprogramm) SPP1226: ‘Nicotine—Molecular and Physiological Effects in CNS’, was intended to overcome some of these inherent problems of current genetic studies of ND. The multi‐centre study is a population‐based case‐control study of smokers and never‐smokers (n = 2396). The study was unique worldwide because it was the first large‐scale genetic study specifically addressing ND with the collection of a wide range of environmental, psychosocial and neurobiological phenotypes. Study design and major population characteristics with emphasis on risk prediction of smoking status were presented in this paper.
Skeletal pattern in subjects with temporomandibular joint disorders

Introduction To establish the skeletal pattern in subjects with malocclusions and temporomandibular disorders (TMD); to assess the relationship between craniofacial skeletal structures and TMD in subjects with malocclusions. Material and methods Sixty-four subjects with malocclusions, over 18 years of age, were included in the study. Temporomandibular disorders were clinically assessed according to the Helkimo Anamnestic Index. Subjects underwent a lateral cephalogram. Subjects were grouped according to the sagittal skeletal pattern (ANB angle) into class I, II and III. Parametric Student tests with equal or unequal variations were used (variations were previously tested with Levene test). Results Twenty-four patients with TMD (experimental sample); 40 patients without TMD (control group); interincisal angle was higher in class I and II (p < 0.05) experimental subjects; overjet was larger in experimental subjects; midline shift and Wits appraisal were broader in the experimental group in all three classes. In class III subjects, the SNB angle was higher in the experimental group (p = 0.01). Joint noises followed by reduced mandible mobility, muscular pain and temporomandibular joint (TMJ) pain were the most frequent symptoms in subjects with TMD and malocclusions. Conclusions Temporomandibular joint status is an important factor to consider when planning orthodontic treatment in patients with severe malocclusions; midline shift, large overjet and deep overbite have been associated with signs and symptoms of TMD.
Lesbian and bisexual women's experiences of sexuality-based discrimination and their appearance concerns

Lesbian and bisexual women frequently experience sexuality-based discrimination, which is often based on others' judgements about their appearance. This short article aims to explore whether there is a relationship between lesbian and bisexual women's experiences of sexuality-based discrimination and their satisfaction with the way that they look. Findings from an online survey suggest that discrimination is negatively related to appearance satisfaction for lesbian women, but not for bisexual women. It is argued that this difference exists because lesbian appearance norms are more recognisable and distinctive than bisexual women's appearance norms.
The embodied state: governmentality in a Brazilian favela

Given that the influence of the state apparatus tends to vary across space, it has been frequently presumed that the state develops a stronger presence in wealthier neighborhoods (where levels of capital accumulation are higher) than it does in poorer ones. In Brazilian favelas (urban slums), as a prominent example, ethnographic accounts have previously suggested that the presence of the ‘official’ state is limited and on the decline. Based on the results of intensive fieldwork in Fortaleza, Brazil, this paper complicates that argument, positing that the state, through the effects of governmentality, may actually have a much stronger presence in favelas than has often been presumed. Drawing upon case research with favela residents, and interpreting through a Foucaultian perspective, this paper explains the increasing presence of the state through the governmentality produced in urban space. By recognizing how the state manifests both in and through bodies and space, researchers are provided better traction for understanding proliferating urban slums and explaining the political landscapes they engender.
Predictors of Parenting Stress in Families of Children With Spina Bifida

Examining predictors of stress in a diverse population of caregivers of children with spina bifida, we examined whether any of the same factors characterized caregivers who choose to access available support services. Participants were caretakers of 56 children with spina bifida, ages 1-17 years, who completed paper-and-pencil measures of parenting stress and social support. Multiple regression analyses revealed that maternal age emerged as the sole predictor of parenting stress, with older mothers reporting higher stress. Caregivers with higher stress related to child interaction were less likely to participate in support services. Findings were interpreted to suggest that traditional models of family support and outreach might not be sufficient to reach caregivers who report higher stress. In addition to family-centered early intervention, families might need sustained support throughout their children's school years.
The Group Paradigm for Concurrency Control Protocols

The authors propose a paradigm for developing, describing, and proving the correctness of concurrency control protocols for replicated databases in the presence of failures or communication restrictions. The approach used is to hierarchically divide the problem of achieving one-copy serializability by introducing the notion of a 'group' that is a higher level of abstraction than transactions. Instead of dealing with the overall problem, the paradigm breaks it into two simpler ones: (1) a local policy for each group that ensures a total order of all transactions in that group; and (2) a global policy that ensures a correct serialization of all groups. The paradigm is used to demonstrate the similarities between several concurrency control protocols by comparing the way they achieve correctness. >
State policy and regional diversity in the provision of secondary education for the youth of Sydney, 1960-2001

Introduction The capacity of regions within nation-states to produce substantially different histories of school provision and access despite the pretensions of overarching state policy has long been recognized in the UK and the USA. Indeed the governmental arrangements associated with schooling in those nations have usually and formally recognized a significant role for local authorities in the provision of public education. Although this role has diminished in the UK from the period of the educational reforms of the Thatcher government, local variation in schooling provision remains significant, as it does in the USA where new central initiatives, such as those associated with charter schools, often increase distinctive regional patterns. Regional diversity in education may take several forms. In this paper, the two forms that are addressed are the public provision of different kinds of schools, and the variations in social participation in those schools. Both are responsive to state policy. In Australia, the analysis of regional diversity as a means of understanding school access and provision has been limited. The tradition of Australian public schooling since the colonial education acts establishing compulsion (mainly in the 1870s, and in New South Wales, 1880) was vigorously centralizing in act and deed. Explaining ‘centralization’ and the parallel development of intrusive regimes of bureaucratic surveillance and governance in public schooling has been an important and necessary focus of much Australian educational historiography. Nevertheless, regional variations remained even at the historical high points of centralized control and, as will be argued in this paper, have grown rapidly as the decentralization and devolutionary policies associated with late twentieth-century neoliberalism have had their impact on schooling arrangements. In Australia, the rural–urban divide has produced substantial diversity but, as this paper will show, the diversity within urban areas has also been substantial.
Enhancement of Mechanical and Thermal Properties of Polycaprolactone/Chitosan Blend by Calcium Carbonate Nanoparticles

This study investigates the effects of calcium carbonate (CaCO3) nanoparticles on the mechanical and thermal properties and surface morphology of polycaprolactone (PCL)/chitosan nanocomposites. The nanocomposites of PCL/chitosan/CaCO3 were prepared using a melt blending technique. Transmission electron microscopy (TEM) results indicate the average size of nanoparticles to be approximately 62 nm. Tensile measurement results show an increase in the tensile modulus with CaCO3 nanoparticle loading. Tensile strength and elongation at break show gradual improvement with the addition of up to 1 wt% of nano-sized CaCO3. Decreasing performance of these properties is observed for loading of more than 1 wt% of nano-sized CaCO3. The thermal stability was best enhanced at 1 wt% of CaCO3 nanoparticle loading. The fractured surface morphology of the PCL/chitosan blend becomes more stretched and homogeneous in PCL/chitosan/CaCO3 nanocomposite. TEM micrograph displays good dispersion of CaCO3 at lower nanoparticle loading within the matrix.
Invasive Carcinoma Derived From Intestinal-Type Intraductal Papillary Mucinous Neoplasm Is Associated With Minimal Invasion, Colloid Carcinoma, and Less Invasive Behavior, Leading to a Better Prognosis

Objectives: Although intestinal-type intraductal papillary mucinous carcinoma (IPMC) is reported to have a better prognosis, few studies have addressed its invasive pattern. The meaning of "minimal invasion" (MI) in IPMC also remains unclear. We investigated the prognosis of intraductal papillary mucinous neoplasm (IPMN) focusing on MI and subtypes. Methods: We evaluated 71 patients with IPMC among a total of 179 patients with resected IPMN. Results: Although 2 of 10 MI-IPMC patients had lymph node metastasis, there were no disease-specific deaths among the MI-IPMC patients. Minimally invasive IPMCs were more frequently observed in intestinal-type IPMC (23/33 cases) than in non-intestinal-type IPMCs (16/38 cases; P = 0.019). Among 32 patients with massively invasive IPMC, the prognosis was significantly better for patients with intestinal-type IPMC than for patients with non-intestinal-type IPMC (P = 0.013). When confined to massively invasive IPMC, tubular invasion (P < 0.001) and lymphatic (P = 0.001) or serosal (P = 0.021) invasion were less frequently observed in intestinal-type IPMC than in non-intestinal-type IPMC. Conclusions: Invasive carcinoma derived from intestinal-type IPMN is associated with MI, colloid carcinoma, and less invasive behavior.
Two Novel Motifs of Watermelon Silver Mottle Virus NSs Protein Are Responsible for RNA Silencing Suppression and Pathogenicity

The NSs protein of Watermelon silver mottle virus (WSMoV) is the RNA silencing suppressor and pathogenicity determinant. In this study, serial deletion and point-mutation mutagenesis of conserved regions (CR) of NSs protein were performed, and the silencing suppression function was analyzed through agroinfiltration in Nicotiana benthamiana plants. We found two amino acid (aa) residues, H113 and Y398, are novel functional residues for RNA silencing suppression. Our further analyses demonstrated that H113 at the common epitope (CE) (109KFTMHNQ117), which is highly conserved in Asia type tospoviruses, and the benzene ring of Y398 at the C-terminal β-sheet motif (397IYFL400) affect NSs mRNA stability and protein stability, respectively, and are thus critical for NSs RNA silencing suppression. Additionally, protein expression of other six deleted (ΔCR1-ΔCR6) and five point-mutated (Y15A, Y27A, G180A, R181A and R212A) mutants were hampered and their silencing suppression ability was abolished. The accumulation of the mutant mRNAs and proteins, except Y398A, could be rescued or enhanced by co-infiltration with potyviral suppressor HC-Pro. When assayed with the attenuated Zucchini yellow mosaic virus vector in squash plants, the recombinants carrying individual seven point-mutated NSs proteins displayed symptoms much milder than the recombinant carrying the wild type NSs protein, suggesting that these aa residues also affect viral pathogenicity by suppressing the host silencing mechanism.
In Vitro Cultivation of Microsporidia of Clinical Importance

SUMMARY Although attempts to develop methods for the in vitro cultivation of microsporidia began as early as 1937, the interest in the culture of these organisms was confined mostly to microsporidia that infect insects. The successful cultivation in 1969 of Encephalitozoon cuniculi, a microsporidium of mammalian origin, and the subsequent identification of these organisms as agents of human disease heightened interest in the cultivation of microsporidia. I describe the methodology as well as the cell lines, the culture media, and culture conditions used in the in vitro culture of microsporidia such as Brachiola (Nosema) algerae, Encephalitozoon cuniculi, E. hellem, E. intestinalis, Enterocytozoon bieneusi, Trachipleistophora hominis, and Vittaforma corneae that cause human disease.