Miracle-dz/UniFAR-FTUs huggingface dataset:
Micrometastasis in lymph nodes and microinvasion of the muscularis propria in primary lesions of submucosal gastric cancer.

BACKGROUND It is important to clarify the clinicopathologic characteristics of micrometastasis in lymph nodes and microinvasion in primary lesions for the treatment options with regard to submucosal gastric cancer. METHODS We examined 1945 lymph nodes and 68 primary tumors resected from 79 patients with submucosal gastric cancer. Two consecutive sections were prepared for simultaneous staining with ordinary hematoxylin and eosin and immunostaining with anticytokeratin antibody (CAM 5.2), respectively. RESULTS The incidence of nodal involvement in 79 patients with submucosal gastric cancer increased from 13% (10/79 patients) by hematoxylin and eosin staining to 34% (27/79 patients) by cytokeratin immunostaining. Micrometastases in the lymph nodes were found in 17 of 69 patients (25%), with cancer-free nodes examined by hematoxylin and eosin. Microinvasion to the muscularis propria was found in 11 of 68 patients (16%) who were histologically diagnosed with submucosal gastric cancer. Survival analysis demonstrated a lesser 5-year survival in the patients with micrometastasis in lymph nodes (82%) and with microinvasion to muscularis propria (73%). A high incidence of nodal involvement was found in submucosal cancers of large size (> 2 cm; 43%), a depressed type (48%), lymphatic invasion (73%), and deeper submucosal invasion (submucosal 3, 53%). A higher incidence of microinvasion was found with the diffuse-type carcinoma (33%). CONCLUSIONS Cytokeratin immunostaining is useful for detecting micrometastasis and microinvasion in submucosal gastric cancer. Tumor size, macroscopic type, lymphatic invasion, and the depth of submucosal invasion are strongly associated with lymph node involvement.
Factors influencing unspecified chest pain admission rates in England

Background Unspecified chest pain is an important and potentially avoidable cause of emergency hospital admission. We aimed to examine inter-hospital variation in admission rates with unspecified chest pain and identify population characteristics, services and technologies that might explain this variation. Methods We used Hospital Episodes Statistics data from 152 acute trusts in England to calculate a direct standardised annual admission rate per 100 000 population for each trust. Regression analysis was used to identify factors explaining variation, first, using routinely available data relating to the hospital catchment area and service and then using responses to a survey of emergency department (ED) management. Results The best predictors of admission rate using routine data were total beds per 1000 population (p=0.001), rapid access chest pain clinic (RACPC) attendances per year (p<0.001) and percentage of households in poverty (p=0.01). Including data from 105/142 (74%) survey responses, the best predictors of admission rate were total beds (p<0.001), RACPC attendances (p=0.001), mean ED waiting time (p=0.049) and percentage of households in poverty (p<0.001). All associations were positive (higher variable predicts higher rate) except ED waiting time. We found no significant associations between factors relating to acute chest pain management and admission rate. Conclusions Hospitals with higher admission rates for unspecified chest pain have greater bed provision, more RACPC attendances and serve populations with a higher percentage of households in poverty. These findings may be explained by services responding to demand in populations with greater need. We found no evidence that chest pain management influenced admission rates.
Gum Elastic Bougie-guided Insertion of the ProSeal™ Laryngeal Mask Airway

We tested the hypothesis that gum elastic-bougie-guided insertion of the ProSeal™ Laryngeal Mask Airway is more frequently successful than introducer tool guided insertion after failed digital insertion. One hundred anaesthetized patients (ASA 1-2, aged 18 to 80 years) were randomized for the second insertion attempt using either the gum elastic bougie-guided or introducer tool techniques. The bougie-guided technique involved priming the drain tube with the bougie, placing the bougie in the oesophagus using laryngoscope guidance, digital insertion along the palato-pharyngeal curve, and bougie removal. The introducer tool technique involved attaching the introducer tool, single-handed rotation along the palatopharyngeal curve, and introducer tool removal. Failed insertion was classified as (i) failed passage into the pharynx, (ii) malposition, or (iii) ineffective ventilation. Any blood staining was documented. Insertion was more frequently successful (50/50 vs 15/50, P=0.0002) and faster (35±17s vs 54±45s, mean±SD, P=0.006) with the bougie-guided technique. All failed insertions with the introducer tool technique were successful with the bougie-guided technique. The aetiology of failed insertion was similar for the digital and introducer tool techniques in 94% (33/35) of patients. There was no blood staining on the bougie, laryngoscope or introducer tool at removal, but blood staining was more common on the Proseal laryngeal mask airway with the introducer tool technique (9/50 vs 2/50, P=0.03). We conclude that the gum elastic bougie-guided insertion has a higher success rate and causes less trauma than the insertion tool insertion technique after failed digital insertion of the Proseal Laryngeal Mask Airway.
Evaluation of the Gratitude Questionnaire in a Chinese Sample of Adults: Factorial Validity, Criterion-Related Validity, and Measurement Invariance Across Sex

The Gratitude Questionnaire (GQ; McCullough et al., 2002) is one of the most widely used instruments to assess dispositional gratitude. The purpose of this study was to validate a Chinese version of the GQ by examining internal consistency, factor structure, convergent validity, and measurement invariance across sex. A total of 1151 Chinese adults were recruited to complete the GQ, Positive Affect and Negative Affect Scales, and Satisfaction with Life Scale. Confirmatory factor analysis indicated that the original unidimensional model fitted well, which is in accordance with the findings in Western populations. Furthermore, the GQ had satisfactory composite reliability and criterion-related validity with measures of life satisfaction and affective well-being. Evidence of configural, metric and scalar invariance across sex was obtained. Tests of the latent mean differences found females had higher latent mean scores than males. These findings suggest that the Chinese version of GQ is a reliable and valid tool for measuring dispositional gratitude and can generally be utilized across sex in the Chinese context.
Risk factors for lacune subtypes in the Atherosclerosis Risk in Communities (ARIC) Study

Objective: Lacunar infarctions are mainly due to 2 microvascular pathologies: lipohyalinosis and microatheroma. Little is known about risk factor differences for these subtypes. We hypothesized that diabetes and glycated hemoglobin (HbA1c) would be related preferentially to the lipohyalinotic subtype. Methods: We performed a cross-section analysis of the brain MRI data from 1,827 participants in the Atherosclerosis Risk in Communities study. We divided subcortical lesions ≤20 mm in diameter into those ≤7 mm (of probable lipohyalinotic etiology) and 8–20 mm (probably due to microatheroma) and used Poisson regression to investigate associations with the number of each type of lesion. Unlike previous studies, we also fitted a model involving lesions <3 mm. Results: Age (prevalence ratio [PR] 1.11 per year; 95% confidence interval [CI] 1.08–1.14), black ethnicity (vs white, PR 1.66; 95% CI 1.27–2.16), hypertension (PR 2.12; 95% CI 1.61–2.79), diabetes (PR 1.42; 95% CI 1.08–1.87), and ever-smoking (PR 1.34; 95% CI 1.04–1.74) were significantly associated with lesions ≤7 mm. Findings were similar for lesions <3 mm. HbA1c, substituted for diabetes, was also associated with smaller lesions. Significantly associated with 8–20 mm lesions were age (PR 1.14; 95% CI 1.09–1.20), hypertension (PR 1.79; 95% CI 1.14–2.83), ever-smoking (PR 2.66; 95% CI 1.63–4.34), and low-density lipoprotein (LDL) cholesterol (PR 1.27 per SD; 95% CI 1.06–1.52). When we analyzed only participants with lesions, history of smoking (PR 1.99; 95% CI 1.23–3.20) and LDL (PR 1.33 per SD; 95% CI 1.08–1.65) were associated with lesions 8–20 mm. Conclusions: Smaller lacunes (even those <3 mm) were associated with diabetes and HbA1c, and larger lacunes associated with LDL cholesterol, differences which support long-held theories relating to their underlying pathology. The findings may contribute to broader understanding of cerebral microvascular disease.
GEOREFERENCING ACCURACY OF GEOEYE-1 STEREO IMAGERY: EXPERIENCES IN A JAPANESE TEST FIELD

High-resolution satellite imagery (HRSI) is being increasingly employed for large-scale topographic mapping, and especially for geodatabase updating. As the spatial resolution of HRSI sensors increases, so the potential georeferencing accuracy also improves. However, accuracy is not a function of spatial resolution alone, as it is also dependent upon radiometric image quality, the dynamics of the image scanning, and the fidelity of the sensor orientation model, both directly from orbit and attitude observations and indirectly from ground control points (GCPs). Users might anticipate accuracies of, say, 1 pixel in planimetry and 1-3 pixels in height when using GCPs. However, there are practical and in some cases administrative/legal imperatives for the georeferencing accuracy of HRSI systems to be quantified through well controlled tests. This paper discusses an investigation into the georeferencing accuracy attainable from the GeoEye-1 satellite, and specifically the 3D accuracy achievable from stereo imagery. Both direct georeferencing via supplied RPCs and indirect georeferencing via ground control and bias-corrected RPCs were examined for a stereo pair of pansharpened GeoEye-1 Basic images covering the Tsukuba Test Field in Japan, which contains more than 100 precisely surveyed and image identifiable GCPs. Salient aspects of the investigation are discussed, including aspects of sensor orientation via bias-corrected RPCs, whether GCPs are required, and the relationship between geolocation accuracy and the number and quality of GCPs. The paper discusses the results obtained, which indicated that the direct georeferencing accuracy obtained was within that specified for GeoEye-1, namely a 2m Circular Error 90% (CE90) in planimetry and a 3m Linear Error 90% (LE90) in height. The use of a few GCPs improved geopositioning accuracy to around 0.35m (0.7 pixel) in planimetry and 0.7m (1.4 pixel) in height. * Corresponding author.
Active Learning for Autonomous Intelligent Agents: Exploration, Curiosity, and Interaction

In this survey we present different approaches that allow an intelligent agent to explore autonomous its environment to gather information and learn multiple tasks. Different communities proposed different solutions, that are in many cases, similar and/or complementary. These solutions include active learning, exploration/exploitation, online-learning and social learning. The common aspect of all these approaches is that it is the agent to selects and decides what information to gather next. Applications for these approaches already include tutoring systems, autonomous grasping learning, navigation and mapping and human-robot interaction. We discuss how these approaches are related, explaining their similarities and their differences in terms of problem assumptions and metrics of success. We consider that such an integrated discussion will improve inter-disciplinary research and applications.
Integrating Spirituality into Undergraduate Nursing Curricula

Nursing programs have done a commendable job keeping pace with the rapid advances in disease management. Yet, spirituality has received far less attention in nursing curricula (Keefe, 2005) and nursing students often do not have a strong foundation in this area. The purpose of this project was to integrate spirituality into the undergraduate nursing curricula and measure student outcomes related to spiritual knowledge and attitudes. Nursing faculty participated in a spirituality education program and followed this with sessions focused on integration of spiritual content into individual nursing courses. Student pre and post-tests were administered using a standard instrument to evaluate the effectiveness of the program. Significant differences in spirituality knowledge and attitudes among senior-level nursing students (t = -3.059, p = .004) were revealed. As the healthcare system becomes increasingly complex, providing students with tools to identify and strengthen inner resources is essential to patient care.
THE USE OF COMPUTERIZED CONTRAST SENSITIVITY, ARDEN GRATINGS AND LOW CONTRAST LETTER CHARTS IN THE ASSESSMENT OF AMBLYOPIA

Abstract—Contrast sensitivity measured with an electronic display was compared with Arden gratings and low contrast letter charts in normal and amblyopic children and adults. The low contrast letter charts and the Arden gratings used in the conventional manner revealed no additional information over that obtained by conventional Snellen acuity. However, the interocular differences found with each plate of the Arden gratings compared favourably with the computerized CSF. With the addition of an extra plate to test at a higher spatial frequency, the Arden gratings would be a useful technique for monitoring amblyopia therapy.
Down‐Regulation of the Noradrenaline Transporter by Interferon‐α in Cultured Bovine Adrenal Medullary Cells

Abstract: The aim of this study was to investigate the effect of long‐term treatment with interferon (IFN)‐α on the noradrenaline transporter of bovine adrenal medullary cells. Treatment of cultured adrenal medullary cells with IFN‐α caused a decrease in uptake of [3H]noradrenaline by the cells in time (4–48 h)‐ and concentration (300–1,000 U/ml)‐dependent manners. IFN‐β also inhibited [3H]noradrenaline uptake to a lesser extent than did IFN‐α, whereas IFN‐γ had little effect. An anti‐IFN‐α antibody reduced the effect of IFN‐α on [3H]noradrenaline uptake. Saturation analysis of [3H]noradrenaline uptake showed that the inhibitory effect of IFN‐α was due to a reduction in the maximal uptake velocity (Vmax) values without altering apparent Michaelis constant (Km) values. Incubation of cells with IFN‐α caused a translocation of protein kinase C from the soluble to the particulate fraction in the cells. The effect of IFN‐α on [3H]noradrenaline uptake was diminished in protein kinase C‐down‐regulated cells. Incubation of cells with IFN‐α for 48 h significantly reduced the specific binding of [3H]desipramine to crude plasma membranes isolated from cells. Scatchard analysis of [3H]desipramine binding revealed that IFN‐α decreased the maximal binding (Bmax) values without any change in the dissociation constant (KD) values. These findings suggest that IFN‐α suppresses the function of noradrenaline transporter by reducing the density of the transporter in cell membranes through, at least in part, a protein kinase C pathway.
The structure and stability of molecular cloud cores in external radiation fields

We have considered the thermal equilibrium in pre-protostellar cores in the approximation where the dust tempera- ture is independent of interactions with the gas and where the gas is heated both by collisions with dust grains and ionization by cosmic rays. We have then used these results to study the stability of cores in hydrostatic equilibrium in the limit where thermal pressure dominates over magnetic field and turbulence. We compare the density distribution derived in this manner with results obtained in the isothermal case. We find that for cores with characteristics similar to those observed in nearby molecular clouds, the gas and dust temperatures are coupled in the core interior with densities above ∼3×10 4 cm −3 . As a consequence, one expects that the gas temperature like the dust temperature decreases towards the center of these objects. However, the regime where gas and dust temperatures are coupled coincides approximately with that in which CO and many other molecular species deplete onto dust grain surfaces. At larger radii and lower densities, the gas and dust temperatures decouple and the gas temperature tends to the value expected for cosmic ray heating alone. The density structure which one computes taking into account such deviations from isothermality are not greatly different from that expected for an isothermal Bonnor-Ebert sphere. It is impossi- ble in the framework of these models to have a stable equilibrium core with mass above ∼5 Mand column density compatible with observed values (NH > 2 × 10 22 cm −2 or AV > 10 mag). We conclude from this that observed high mass cores are either supported by magnetic field or turbulence or are already in a state of collapse. Lower mass cores on the other hand have stable states where thermal pressure alone provides support against gravitation and we conclude that the much studied object B68 may be in a state of stable equilibrium if the internal gas temperature is computed in self-consistent fashion. Finally we note that in molecular clouds such as Ophiuchus and Orion with high radiation fields and pressures, gas and dust temperatures are expected to be well coupled and hence in the absence of an internal heat source, one expects temperatures to decrease towards core centers and to be relatively high as compared to low pressure clouds like Taurus.
MODULAR NEURAL NETWORK BASED ARRHYTHMIA CLASSIFICATION SYSTEM USING ECG SIGNAL DATA

This research is on presenting a new approach for cardiac arrhythmia disease classification. The proposed method uses Modular neural network (MNN) model to classify arrhythmia into normal and abnormal classes. We have performed experiments on UCI Arrhythmia data set [8]. Missing attribute values of this data set are replaced by closest column value of the concern class. We have constructed neural network model by varying number of hidden layers from one to three and are trained by varying training percentage in data set partitions. In this study, we are mainly interested in producing high confident arrhythmia classification results to be applicable in diagnostic decision support systems. This data set is a good environment to test classifiers as it is incomplete and ambiguous bio-signal data collected from total 452 patient cases. The classification performance is evaluated using six measures; sensitivity, specificity, classification accuracy, mean squared error (MSE), receiver operating characteristics (ROC) and area under curve (AUC). The experimental results presented in this paper show that more than 82.22% testing classification accuracy may be obtained.
Alterations in T 1 of normal and reperfused infarcted myocardium after Gd‐BOPTA versus GD‐DTPA on inversion recovery EPI†

This study tested whether Gd‐BOPTA/Dimeg or Gd‐DTPA exerts greater relaxation enhancement for blood and reperfused infarcted myocardium. Relaxivity of Gd‐BOPTA is increased by weak binding to serum albumin. Thirty‐six rats were subjected to reperfused infarction before contrast (doses = 0.05, 0.1, and 0.2 mmol/kg). ΔR1 was repeatedly measured over 30 min. Gd‐BOPTA caused greater ΔR1 for blood and myocardium than did Gd‐DTPA clearance of both agents from normal and infarcted myocardium was similar to blood clearance; plots of ΔR1myocardium/ΔR1blood showed equilibrium phase contrast distribution. Fractional contrast agent distribution volumes were approximately 0.24 for both agents in normal myocardium, 0.98 and 1.6 for Gd‐DTPA and Gd‐BOPTA, respectively, in reperfused infarction. The high value for Gd‐BOPTA was ascribed to greater relaxivity in infarction versus blood. It was concluded that Gd‐BOPTA/Dimeg causes a greater ΔR1 than Gd‐DTPA in regions which contain serum albumin.
Assessing acceptance of assistive social robots by aging adults

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Pantoprazole before Endoscopy in Patients with Gastroduodenal Ulcer Bleeding: Does the duration of Infusion and Ulcer Location Influence the Effects?

The aim of this study was to investigate the effect of preemptive pantoprazole infusion on early endoscopic findings in patients with acute ulcer bleeding. Records of 333 patients admitted with acute ulcer bleeding were analyzed. Ulcer bleeders were given either 80 mg bolus of pantoprazole followed by continuous infusion of 8 mg per hour or saline infusion until endoscopy. In 93 patients saline infusion whereas in 240 patients bolus plus infusion of pantoprazole was administrated with mean (±SD) durations of 5.45 ± 12.9 hours and 6.9 ± 13.2 hours, respectively (P = 0.29). Actively bleeding ulcers were detected in 46/240 (19.2%) of cases in the pantoprazole group as compared with 23/93 (24.7%) in the saline infusion group (P = 0.26). Different durations of pantoprazole infusion (0–4 hours, >4 hours, and >6 hours) had no significant effect on endoscopic and clinical outcome parameters in duodenal ulcer bleeders. Gastric ulcer bleeders on pantoprazole infusion longer than 4 and 6 hours before endoscopy had actively bleeding ulcers in 4.3% and 5% compared to the 19.5% active bleeding rate in the saline group (P = 0.02 and P = 0.04). Preemptive infusion of high-dose pantoprazole longer than 4 hours before endoscopy decreased the ratio of active bleeding only in gastric but not in duodenal ulcer patients.
Optimizing Content Caching to Maximize the Density of Successful Receptions in Device-to-Device Networking

Device-to-device (D2D) communication is a promising approach to optimize the utilization of air interface resources in 5G networks, since it allows decentralized opportunistic short-range communication. For D2D to be useful, mobile nodes must possess content that other mobiles want. Thus, intelligent caching techniques are essential for D2D. In this paper, we use results from stochastic geometry to derive the probability of successful content delivery in the presence of interference and noise. We employ a general transmission strategy, where multiple files are cached at the users and different files can be transmitted simultaneously throughout the network. We then formulate an optimization problem, and find the caching distribution that maximizes the density of successful receptions (DSR) under a simple transmission strategy, where a single file is transmitted at a time throughout the network. We model file requests by a Zipf distribution with exponent γr, which results in an optimal caching distribution that is also a Zipf distribution with exponent γc, which is related to γr through a simple expression involving the path loss exponent. We solve the optimal content placement problem for more general demand profiles under Rayleigh, Ricean, and Nakagami small-scale fading distributions. Our results suggest that it is required to flatten the request distribution to optimize the caching performance. We also develop strategies to optimize content caching for the more general case with multiple files, and bound the DSR for that scenario.