Miracle-dz/UniFAR-FTUs huggingface dataset:
Intelligent surface normal measurement method of end effector for the aeronautical drilling robot

In order to solve the perpendicularity of robotic drilling in the aircraft assembly, this paper proposed a novel surface normal measurement method for the aeronautical drilling robot. Firstly, vision location module is used to mark the drilling point and get the coordinate of drilling point. Meanwhile, four laser range sensors start to measure the distance between the emitting laser points and their subpoints on the workpiece surface. Thus, the coordinates of four subpoints can be obtained. According to the four subpoints and drilling point, line or circle are used to approach two curves through the drilling point on the workpiece surface. Two tangent vectors of the two curves at drilling point can be obtained. Then the normal vector of drilling point can be calculated from the cross product of two tangent vectors. The angle between the normal vector and drill axis vector can be obtained. If the angle is greater than 0.5 degree, the two eccentric discs will rotate definite angles to meet the requirement. Finally, the simulation results and experimental results on the aeronautical drilling robot show that the surface normal measurement method is valid and effective to meet the requirement in aircraft assembly.
High-throughput screening for evidence of association by using mass spectrometry genotyping on DNA pools

To facilitate positional cloning of complex trait susceptibility loci, we are investigating methods to reduce the effort required to identify trait-associated alleles. We examined primer extension analysis by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry to screen single-nucleotide polymorphisms (SNPs) for association by using DNA pools. We tested whether this method can accurately estimate allele frequency differences between pools while maintaining the high-throughput nature of assay design, sample handling, and scoring. We follow up interesting allele frequency differences in pools by genotyping individuals. We tested DNA pools of 182, 228, and 499 individuals using 16 SNPs with minor allele frequencies 0.026–0.486 and allele frequency differences 0.001–0.108 that we had genotyped previously on individuals and 381 SNPs that we had not. Precision, as measured by the average standard deviation among 16 semidependent replicates, was 0.021 ± 0.011 for the 16 SNPs and 0.018 ± 0.008 for the 291/381 SNPs used in further analysis. For the 16 SNPs, the average absolute error in predicting allele frequency differences between pools was 0.009; the largest errors were 0.031, 0.028, and 0.027. We determined that compensating for unequal peak heights in heterozygotes improved precision of allele frequency estimates but had only a very minor effect on accuracy of allele frequency differences between pools. Based on these data and assuming pools of 500 individuals, we conclude that at significance level 0.05 we would have 95% (82%) power to detect population allele frequency differences of 0.07 for control allele frequencies of 0.10 (0.50).
Effects of glucocorticoids on STAT4 activation in human T cells are stimulus‐dependent

Glucocorticoids affect the immune system by a number of mechanisms, including modulation of cytokine production in lymphocytes. Glucocorticoids suppress T helper cell type 1 immune responses by decreasing the ability of T cells to respond to interleukin (IL)‐12, a major inducer of interferon (IFN)‐γ. IFN‐β increases the expression of the anti‐inflammatory cytokine IL‐10 and suppresses IL‐12. Signaling pathways through IFN‐β and the IL‐12 receptor (IL‐12R) involve activation by phosphorylation of signal transducer and activator of transcription 4 (STAT4). Our aim was to investigate the effects of dexamethasone on STAT4 activation by IFN‐β and IL‐12 in human T cell blasts. We report that dexamethasone decreases IL‐12‐induced STAT4 phosphorylation and IFN‐γ production and enhances IFN‐β‐induced STAT4 activation and IL‐10 production. These effects are associated with a down‐regulation of IL‐12Rβ1 expression but an up‐regulation of IFN‐βR. These results indicate that the effect of glucocorticoids on the STAT4 signaling pathway depends on the stimulus activating that pathway.
Clinical Validation of the Molecular BD GeneOhm StaphSR Assay for Direct Detection of Staphylococcus aureus and Methicillin-Resistant Staphylococcus aureus in Positive Blood Cultures

ABSTRACT The rapid detection of Staphylococcus aureus bacteremia and a swift determination of methicillin susceptibility has serious clinical implications affecting patient mortality. This study evaluated the StaphSR assay (BD GeneOhm, San Diego, CA), a real-time PCR assay, for the identification and differentiation of methicillin-susceptible S. aureus (MSSA) and methicillin-resistant S. aureus (MRSA) from 300 positive blood cultures. The BD GeneOhm StaphSR assay was performed and interpreted according to the manufacturer's recommendations. Positive blood cultures (containing predominantly gram-positive cocci in clusters) were subcultured on 5% sheep blood agar plates. After 18 to 24 h of incubation, isolates morphologically consistent with S. aureus were presumptively identified by latex agglutination (Staphaurex Plus; Remel, Lenexa, KS). Susceptibility testing was initially performed with the Phoenix automated microbiology system (BD Diagnostics, Sparks, MD). Additional susceptibility testing of samples with discrepant results was done using BBL oxacillin screen agar (BD Diagnostics, Sparks, MD), oxacillin and cefoxitin Etests (AB Biodisk, Solna, Sweden) on Mueller-Hinton agar, an immunoassay for penicillin binding protein 2′ (Denka Seiken Co., Tokyo, Japan), and mecA PCR. The sensitivity, specificity, and positive and negative predictive values of the BD GeneOhm StaphSR assay for MSSA detection were 98.9, 96.7, 93.6, and 99.5%, respectively. For the detection of MRSA, the BD GeneOhm StaphSR assay was 100% sensitive and 98.4% specific; positive and negative predictive values for MRSA detection were 92.6 and 100%, respectively. Inhibition was seen with only one sample, and the issue was resolved upon retesting. The BD GeneOhm StaphSR assay appears to be a valuable diagnostic tool for quickly differentiating bacteremia caused by MSSA and MRSA from that caused by other gram-positive cocci.
Effect of a novel microbial phytase on production performance and tibia mineral concentration in broiler chickens given low-calcium diets

Abstract 1. In a 42-d feeding trial, 264 one-d-old, as hatched, Cobb 400 broiler chickens (6 pens per group, n = 11 per pen in a 2 × 2 factorial arrangement) were fed on two concentrations of dietary calcium (Ca) (9.0 and 7.5 g/kg in starter, 7.5 and 6 g/kg in grower phases) and supplemental phytase (0 and 500 U/kg diet). 2. During d 0–21, the high Ca + phytase diet improved body weight. During d 0–42, feed intake was increased by the low Ca diet and decreased by phytase supplementation. Feed conversion ratio during d 0–21 was improved by the high Ca + phytase diet. 3. At d 42, Ca in duodenal digesta was reduced by low dietary Ca and supplemental phytase. High dietary Ca reduced P in duodenal and jejunal digesta. Phytase reduced digesta P and increased serum P concentration. 4. Relative tibia length decreased with low dietary Ca and increased with phytase. The robusticity index of tibia was improved by the low Ca diet and phytase supplementation. Phytase supplementation increased tibia ash and concentrations of Ca, magnesium (Mg), manganese (Mn), copper (Cu), zinc (Zn) and iron (Fe) in tibia. The low Ca diet increased Mg, Mn and Fe and reduced Cu and Zn in tibia. 5. It was concluded that 7.5 g Ca/kg during weeks 0–3 and 6 g Ca/kg during weeks 3–6 sustained broiler performance and bone ash, while phytase supplementation facilitated tibia mineralisation, particularly during the grower phase.
**title** Asp Conference Series, Vol. **volume***, **year of Publication** **names of Editors** Properties of Galaxy Dark Matter Halos from Weak Lensing

We present the results of a study of the average mass profile around galaxies using weak gravitational lensing. We use 45.5 deg 2 of R C band imaging data from the Red-Sequence Cluster Survey (RCS) and define a sample of ∼ 1.2 × 10 5 lenses with 19.5 < R C < 21, and a sample of ∼ 1.5 × 10 6 background galaxies with 21.5 < R < 24. We constrain the power law scaling relations between the B-band luminosity and the mass and size of the halo, and find that the results are in excellent agreement with observed luminosity-line-width relations. Under the assumption that the luminosity does not evolve with redshift, the best fit NFW model yields a mass M 200 = (8.8±0.7)×10 11 h −1 M ⊙ and a scale radius r s = 16.7 +3.7 −3.0 h −1 kpc for a galaxy with a fiducial luminosity of L B = 10 10 h −2 L B⊙. The latter result is in excellent agreement with predictions from numerical simulations for a halo of this mass. We also observe a signficant anisotropy of the lensing signal around the lenses, implying that the halos are flattened and aligned with the light distribution. We find an average (projected) halo ellipticity of e halo = 0.20 +0.04 −0.05 , in fair agreement with results from numerical simulations of CDM. Alternative theories of gravity (without dark matter) predict an isotropic lensing signal, which is excluded with 99.5% confidence. Hence, our results provide strong support for the existence of dark matter.
Loci associated with N-glycosylation of human IgG are not associated with rheumatoid arthritis: a Mendelian randomisation study

Objectives A recent study identified 16 genetic variants associated with N-glycosylation of human IgG. Several of the genomic regions where these single nucleotide polymorphisms (SNPs) reside have also been associated with autoimmune disease (AID) susceptibility, suggesting there may be pleiotropy (genetic sharing) between loci controlling both N-glycosylation and AIDs. We investigated this by testing variants associated with levels of IgG N-glycosylation for association with rheumatoid arthritis (RA) susceptibility using a Mendelian randomisation study, and testing a subset of these variants in a less well-powered study of treatment response and severity. Methods SNPs showing association with IgG N-glycosylation were analysed for association with RA susceptibility in 14 361 RA cases and 43 923 controls. Five SNPs were tested for association with response to anti-tumour necrosis factor (TNF) therapy in 1081 RA patient samples and for association with radiological disease severity in 342 patients. Results Only one SNP (rs9296009) associated with N-glycosylation showed an association (p=6.92×10–266) with RA susceptibility, although this was due to linkage disequilibrium with causal human leukocyte antigen (HLA) variants. Four regions of the genome harboured SNPs associated with both traits (shared loci); although statistical analysis indicated that the associations observed for the two traits are independent. No SNPs showed association with response to anti-TNF therapy. One SNP rs12342831 was modestly associated with Larsen score (p=0.05). Conclusions In a large, well-powered cohort of RA patients, we show SNPs driving levels of N-glycosylation have no association with RA susceptibility, indicating colocalisation of associated SNPs are not necessarily indicative of a shared genetic background or a role for glycosylation in disease susceptibility.
Infants' Reactions to Different Expressions of Emotions.

AUTHOR Kreutzer, Mary Anne; Charlesworth, William R. TITLE Infants' Reactions to Different Expressions of Emotions. INSTITUT:ZON Minnesota Univ., Minneapolis. Irst. of Child Development . SPONS AGENCY National Inst. of Child Health and Human Development (NIH), Bethesda, Md. REPORT NO HD-05027 PUB DATE Mar 73 NOTE 31p. ; Paper presented at the biennial meeting of the Society for Research in Child Developr. t (Philadelphia, Pennsylvania, March 29 April 1, 1973)
Atorvastatin reduces arterial stiffness in patients with rheumatoid arthritis

Background: Chronic systemic inflammation may contribute to accelerated atherosclerosis and increased arterial stiffness in patients with rheumatoid arthritis (RA). In addition to lowering cholesterol, statins have immunomodulatory effects which may be especially beneficial in patients with RA who have systemic immune activation. Objective: To investigate the effect of atorvastatin on the augmentation index (AIx: a measure of arterial stiffness) and systemic inflammation in RA. Methods: 29 patients with RA (mean (SD) age 55 (13) years) with moderately active disease of long duration were studied. AIx, lipid levels, serum inflammatory markers, and disease activity score were measured before and after 12 weeks of atorvastatin 20 mg daily. Results: AIx improved significantly from 34.1 (11.6)% to 29.9 (11)% (p = 0.0002), with the greatest improvements in AIx occurring in those subjects with the highest disease activity scores (r = −0.5, p = 0.007). Total and LDL cholesterol were reduced from 5.5 (0.9) to 3.9 (0.7) mmol/l and 3.3 (0.8) to 1.9 (0.6) mmol/l, respectively (p = 0.0001). Serum inflammatory markers remained unchanged during the study. Conclusions: Atorvastatin significantly reduced arterial stiffness in patients with RA. The greatest improvements were seen in patients with more active disease, suggesting that, in addition to the beneficial effects of cholesterol reduction, immune modulation may contribute to the cardioprotective effect of statins.
Factors influencing the adoption of health information technologies: a systematic review

Introduction The successful implementation of health information technologies requires investigating the factors affecting the acceptance and use of them. The aim of this study was to determine the most important factors affecting the adoption of health information technologies by doing a systematic review on the factors affecting the acceptance of health information technology. Methods This systematic review was conducted by searching the major databases, such as Google Scholar, Emerald, Science Direct, Web of Science, Pubmed, and Scopus. We used various keywords, such as adoption, use, acceptance of IT in medicine, hospitals, and IT theories in health services, and we also searched on the basis of several important technologies, such as Electronic Health Records (HER), Electronic Patient Records (EPR), Electronic Medical Records (EMR), Computerized Physician Order Entry (CPOE), Hospital Information System (HIS), Picture Archiving and Communication System (PACS), and others in the 2004–2014 period. Results The technology acceptance model (TAM) is the most important model used to identify the factors influencing the adoption of information technologies in the health system; also, the unified theory of acceptance and use of technology (UTAUT) model has had a lot of applications in recent years in the health system. Ease of use, usefulness, social impact, facilitating conditions, attitudes and behavior of users are effective in the adoption of health information technologies. Conclusion By considering various factors, including ease of use, usefulness, and social impact, the rate of the adoption of health information technology can be increased.
Parents as tutors of their own children: Effects of reading strategies on third-grade students

PARENTS AS TUTORS OF THEIR OWN CHILDREN: EFFECTS OF READING STRATEGIES ON THIRD GRADE STUDENTS MAY 1994 CAROL A. MacDONALD, B.S. BOSTON UNIVERSITY M.Ed. BRIDGEWATER STATE COLLEGE Ed.D. UNIVERSITY OF MASSACHUSETTS AMHERST Directed by: Associate Professor Alfred L. Karlson The study was designed to investigate the effects of a parent intervention training program and its impact on reading achievement at the third grade level. Parents of grade three students in a suburban community west of Boston, Massachusetts were trained to use specific reading strategies to tutor their own children. The study attempted to show what would result when parents were trained as tutors to deliver specific oral reading strategies such as: (a) correcting miscues only when they disrupt meaning and after waiting for the child to selfcorrect; (b) using sustaining cues to encourage the child to use context to identify words; and (c) praising the child for self-correcting and using context. Parents participated in three training sessions that lasted
Flux and color variations of the quadruply imaged quasar HE 0435-1223

Aims. We present VRi photometric observations of the quadruply imaged quasar HE0435-1223, carried out with the Danish 1.54 m telescope at the La Silla Observatory. Our aim was to monitor and study the magnitudes and colors of each lensed component as a function of time. Methods. We monitored the object during two seasons (2008 and 2009) in the VRi spectral bands, and reduced the data with two independent techniques: difference imaging and point spread function (PSF) fitting. Results. Between these two seasons, our results show an evident decrease in flux by ≈ 0.2–0.4 magnitudes of the four lensed components in the three filters. We also found a significant increase ( ≈ 0.05–0.015) in their V − R and R − i color indices. Conclusions. These flux and color variations are very likely caused by intrinsic variations of the quasar between the observed epochs. Microlensing effects probably also affect the brightest “A” lensed component.
Production and characterization of monoclonal antibodies to tetanus toxin

Monoclonal antibodies against tetanus toxin were produced to obtain highly specific antisera. Ten hybridoma cell lines producing monoclonal antibodies were derived from the fusion of rat myeloma cells and spleen cells from rats immunized with tetanus toxoid. Eight produced monoclonal antibodies specific for determinants on toxin and toxoid, whereas two were specific only for determinants on the toxoid. The antibodies produced by hybridomas were characterized by determination of the class of light and heavy chain components, epitope specificity, toxin neutralization, and subunit specificity. All of the antibodies contained kappa light chain, eight contained the gamma 1 heavy chain, and the remaining two contained the gamma 2a heavy chain. Five distinct epitopes were indicated by competition assay of paired monoclonal antibodies, and 4 of the 10 monoclonal antibodies neutralized the in vivo activity of tetanus toxin. The four neutralizing monoclonal antibodies and one other were specific for the C fragment of the heavy chain of the toxin molecule.
False Memories for Affective Information in Schizophrenia

Studies have shown a direct link between memory for emotionally salient experiences and false memories. In particular, emotionally arousing material of negative and positive valence enhanced reality monitoring compared to neutral material since emotional stimuli can be encoded with more contextual details and thereby facilitate the distinction between presented and imagined stimuli. Individuals with schizophrenia appear to be impaired in both reality monitoring and memory for emotional experiences. However, the relationship between the emotionality of the to-be-remembered material and false memory occurrence has not yet been studied. In this study, 24 patients and 24 healthy adults completed a false memory task with everyday episodes composed of 12 photographs that depicted positive, negative, or neutral outcomes. Results showed how patients with schizophrenia made a higher number of false memories than normal controls (p < 0.05) when remembering episodes with positive or negative outcomes. The effect of valence was apparent in the patient group. For example, it did not affect the production causal false memories (p > 0.05) resulting from erroneous inferences but did interact with plausible, script consistent errors in patients (i.e., neutral episodes yielded a higher degree of errors than positive and negative episodes). Affective information reduces the probability of generating causal errors in healthy adults but not in patients suggesting that emotional memory impairments may contribute to deficits in reality monitoring in schizophrenia when affective information is involved.
Polynomial time quantum algorithm for the computation of the unit group of a number field

We present a quantum algorithm for the computation of the irrational period lattice of a function on Zn which is periodic in a relaxed sense. This algorithm is applied to compute the unit group of finite extensions of Q. Execution time for fixed field degree over Q is polynomial in the discriminant of the field. Our algorithms generalize and improve upon Hallgren's work [9] for the one-dimensional case corresponding to real-quadratic fields.
Why detecting a misspelling in lenguage is easier than in languege: Segmental and suprasegmental influences on orthographic processing

Four studies were conducted to determine the range of phonological information that can affect orthographic processes during reading under different conditions, and to investigate how the influence of phonology on orthography is affected by other relevant factors, such as linguistic context and individual differences in reading-related skills. Study 1 employed a spelling decision task in which phonemic, lexical stress, and syllabic variables were factorially manipulated in misspelled words. Both phonemes and lexical stress affected the speed and accuracy with which misspellings were detected, indicating that both segmental and suprasegmental phonological information can influence orthographic processing. Study 2 comprised two separate experiments designed to compare phonological effects on orthographic processing in a spelling decision task versus a lexical decision task. Both stress and phoneme effects were reduced in the lexical decision experiment relative to the spelling decision experiment, suggesting that the influence of phonology on orthography is stronger when more extensive phonological processing is required or allowed by a task. Study 3 included two series of analyses examining the roles of phonological feedback and individual differences in Study 2 outcomes. The analyses indicated that better spellers are less sensitive than poorer spellers to the influence of phonological feedback during reading, which supports the hypothesis that phonological feedback is a mechanism for orthographic learning. Study 4 embedded stimuli in a proofreading passage to test the hypothesis that the role of stress in reading is enhanced when upcoming stress patterns can be more easily predicted. Misspellings were detected more often in words misspelled in stressed syllables, and in words that were less predictable from context. Spelling error detection for more predictable words was improved when the misspelling occurred in a stressed syllable. These results were consistent with our hypothesis, and suggest that stress plays a greater role in orthographic processing under more natural reading conditions compared to isolated-word reading. Taken together, these studies suggest that phonological information, including both segmental and suprasegmental phonological information, can affect orthographic processing during reading, and that the influence of phonology on orthography can be moderated by reading task, linguistic context, and individual characteristics of the reader.