Miracle-dz/UniFAR-FTUs huggingface dataset:
Control of Metabolic Homeostasis by Stress Signaling Is Mediated by the Lipocalin NLaz

Metabolic homeostasis in metazoans is regulated by endocrine control of insulin/IGF signaling (IIS) activity. Stress and inflammatory signaling pathways—such as Jun-N-terminal Kinase (JNK) signaling—repress IIS, curtailing anabolic processes to promote stress tolerance and extend lifespan. While this interaction constitutes an adaptive response that allows managing energy resources under stress conditions, excessive JNK activity in adipose tissue of vertebrates has been found to cause insulin resistance, promoting type II diabetes. Thus, the interaction between JNK and IIS has to be tightly regulated to ensure proper metabolic adaptation to environmental challenges. Here, we identify a new regulatory mechanism by which JNK influences metabolism systemically. We show that JNK signaling is required for metabolic homeostasis in flies and that this function is mediated by the Drosophila Lipocalin family member Neural Lazarillo (NLaz), a homologue of vertebrate Apolipoprotein D (ApoD) and Retinol Binding Protein 4 (RBP4). Lipocalins are emerging as central regulators of peripheral insulin sensitivity and have been implicated in metabolic diseases. NLaz is transcriptionally regulated by JNK signaling and is required for JNK-mediated stress and starvation tolerance. Loss of NLaz function reduces stress resistance and lifespan, while its over-expression represses growth, promotes stress tolerance and extends lifespan—phenotypes that are consistent with reduced IIS activity. Accordingly, we find that NLaz represses IIS activity in larvae and adult flies. Our results show that JNK-NLaz signaling antagonizes IIS and is critical for metabolic adaptation of the organism to environmental challenges. The JNK pathway and Lipocalins are structurally and functionally conserved, suggesting that similar interactions represent an evolutionarily conserved system for the control of metabolic homeostasis.
Performance-effective operation below Vcc-min

Continuous circuit miniaturization and increased process variability point to a future with diminishing returns from dynamic voltage scaling. Operation below Vcc-min has been proposed recently as a mean to reverse this trend. The goal of this paper is to minimize the performance loss due to reduced cache capacity when operating below Vcc-min. A simple method is proposed: disable faulty blocks at low voltage. The method is based on observations regarding the distributions of faults in an array according to probability theory. The key lesson, from the probability analysis, is that as the number of uniformly distributed random faulty cells in an array increases the faults increasingly occur in already faulty blocks. The probability analysis is also shown to be useful for obtaining insight about the reliability implications of other cache techniques. For one configuration used in this paper, block disabling is shown to have on the average 6.6% and up to 29% better performance than a previously proposed scheme for low voltage cache operation. Furthermore, block-disabling is simple and less costly to implement and does not degrade performance at or above Vcc-min operation. Finally, it is shown that a victim-cache enables higher and more deterministic performance for a block-disabled cache.
Glycylcyclines bind to the high-affinity tetracycline ribosomal binding site and evade Tet(M)- and Tet(O)-mediated ribosomal protection

N,N-dimethylglycylamido (DMG) derivatives of 6-demethyl-6-deoxytetracycline and doxycycline bind 5-fold more effectively than tetracycline to the tetracycline high-affinity binding site on the Escherichia coli 70S ribosome, which correlates with a 10-fold increase in potency for inhibition of E. coli cell-free translation. The potencies of DMG-doxycycline and DMG-6-demethyl-6-deoxytetracycline were unaffected by the ribosomal tetracycline resistance factors Tet(M) and Tet(O) in cell-free translation assays and whole-cell bioassays with a conditional Tet(M)-producing E. coli strain.
Characterization of secretory protein translocation: ribosome-membrane interaction in endoplasmic reticulum

Secretory proteins are synthesized on ribosomes bound to the membrane of the endoplasmic reticulum (ER). After the selection of polysomes synthesizing secretory proteins and their direction to the membrane of the ER via signal recognition particle (SRP) and docking protein respectively, the polysomes become bound to the ER membrane via an unknown, protein-mediated mechanism. To identify proteins involved in protein translocation, beyond the (SRP-docking protein-mediated) recognition step, controlled proteolysis was used to functionally inactivate rough microsomes that had previously been depleted of docking protein. As the membranes were treated with increasing levels of protease, they lost their ability to be functionally reconstituted with the active cytoplasmic fragment of docking protein (DPf). This functional inactivation did not correlate with a loss of either signal peptidase activity, nor with the ability of the DPf to reassociate with the membrane. It did correlate, however, with a loss of the ability of the microsomes to bind ribosomes. Ribophorins are putative ribosome- binding proteins. Immunoblots developed with monoclonal antibodies against canine ribophorins I and II demonstrated that no correlation exists between the protease-induced inability to bind ribosomes and the integrity of the ribophorins. Ribophorin I was 85% resistant and ribophorin II 100% resistant to the levels of protease needed to totally eliminate ribosome binding. Moreover, no direct association was found between ribophorins and ribosomes; upon detergent solubilization at low salt concentrations, ribophorins could be sedimented in the presence or absence of ribosomes. Finally, the alkylating agent N- ethylmaleimide was shown to be capable of inhibiting translocation (beyond the SRP-docking protein-mediated recognition step), but had no affect on the ability of ribosomes to bind to ER membranes. We conclude that potentially two additional proteinaceous components, as yet unidentified, are involved in protein translocation. One is protease sensitive and possibly involved in ribosome binding, the other is N- ethylmaleimide sensitive and of unknown function.
Influence of soil type on strength and microstructure of carbonated reactive magnesia-treated soil

Abstract Accelerated carbonation of reactive magnesia (MgO)-treated soil is an innovative and sustainable method for improving ground through absorbing CO2. The strength and microstructural properties of various types of carbonated soils at varying initial water contents (w0) are explored, and liquid limit (wL), a parameter representing soil type, is highlighted in this paper. The strength properties of carbonated soils are investigated by unconfined compression tests. To explain the carbonation mechanism, the microstructural properties are obtained from different experimental tests: X-ray diffraction, scanning electron microscopy, thermogravimetric analysis and mercury intrusion porosimetry. The results indicate that large amounts of CO2 and water are consumed in the carbonation process, which results in the reduction of water content and the formation of carbonation products such as nesquehonite and hydromagnesite/dypingite. The strength of carbonated soils decreases with the increase in wL or water content. A simplified equation is proposed for predicting the strength of carbonated soils when both the wL and w0 are given. Silt is easier to absorb CO2 for carbonation than silty clay and clay. Moreover, the pore volume and the quantity of carbonation products decrease with increase in wL, and the content of CO2 absorbed decreases with increase in wL or w0.
Diagnostic yield and accuracy of CT angiography, MR angiography, and digital subtraction angiography for detection of macrovascular causes of intracerebral haemorrhage: prospective, multicentre cohort study

Study question What are the diagnostic yield and accuracy of early computed tomography (CT) angiography followed by magnetic resonance imaging/angiography (MRI/MRA) and digital subtraction angiography (DSA) in patients with non-traumatic intracerebral haemorrhage? Methods This prospective diagnostic study enrolled 298 adults (18-70 years) treated in 22 hospitals in the Netherlands over six years. CT angiography was performed within seven days of haemorrhage. If the result was negative, MRI/MRA was performed four to eight weeks later. DSA was performed when the CT angiography or MRI/MRA results were inconclusive or negative. The main outcome was a macrovascular cause, including arteriovenous malformation, aneurysm, dural arteriovenous fistula, and cavernoma. Three blinded neuroradiologists independently evaluated the images for macrovascular causes of haemorrhage. The reference standard was the best available evidence from all findings during one year’s follow-up. Study answer and limitations A macrovascular cause was identified in 69 patients (23%). 291 patients (98%) underwent CT angiography; 214 with a negative result underwent additional MRI/MRA and 97 with a negative result for both CT angiography and MRI/MRA underwent DSA. Early CT angiography detected 51 macrovascular causes (yield 17%, 95% confidence interval 13% to 22%). CT angiography with MRI/MRA identified two additional macrovascular causes (18%, 14% to 23%) and these modalities combined with DSA another 15 (23%, 18% to 28%). This last extensive strategy failed to detect a cavernoma, which was identified on MRI during follow-up (reference strategy). The positive predictive value of CT angiography was 72% (60% to 82%), of additional MRI/MRA was 35% (14% to 62%), and of additional DSA was 100% (75% to 100%). None of the patients experienced complications with CT angiography or MRI/MRA; 0.6% of patients who underwent DSA experienced permanent sequelae. Not all patients with negative CT angiography and MRI/MRA results underwent DSA. Although the previous probability of finding a macrovascular cause was lower in patients who did not undergo DSA, some small arteriovenous malformations or dural arteriovenous fistulas may have been missed. What this study adds CT angiography is an appropriate initial investigation to detect macrovascular causes of non-traumatic intracerebral haemorrhage, but accuracy is modest. Additional MRI/MRA may find cavernomas or alternative diagnoses, but DSA is needed to diagnose macrovascular causes undetected by CT angiography or MRI/MRA. Funding, competing interests, data sharing Dutch Heart Foundation and The Netherlands Organisation for Health Research and Development, ZonMw. The authors have no competing interests. Direct requests for additional data to the corresponding author.
A Method for Watermarking Java Programs via Opaque Predicates

In this paper, we present a method for watermarking Java programs that uses opaque predicates, improving upon those presented in two previous papers [13, 9]. We present two algorithms: the first is simpler to implement and to analyze, but certain distortive attacks can make watermark extraction difficult; the second is more complex, but under realistic assumptions yields good resistance to all usual types of attacks.
GloVe: Global Vectors for Word Representation

Recent methods for learning vector space representations of words have succeeded in capturing fine-grained semantic and syntactic regularities using vector arithmetic, but the origin of these regularities has remained opaque. We analyze and make explicit the model properties needed for such regularities to emerge in word vectors. The result is a new global logbilinear regression model that combines the advantages of the two major model families in the literature: global matrix factorization and local context window methods. Our model efficiently leverages statistical information by training only on the nonzero elements in a word-word cooccurrence matrix, rather than on the entire sparse matrix or on individual context windows in a large corpus. The model produces a vector space with meaningful substructure, as evidenced by its performance of 75% on a recent word analogy task. It also outperforms related models on similarity tasks and named entity recognition.
Kinematic model for the Main Central thrust in Nepal

We present a kinematic model for the Himalayan thrust belt that satisfies structural and metamorphic data and explains recently reported late Miocene‐Pliocene geochronologic and thermochronologic ages from rocks in the Main Central thrust zone in central Nepal. At its current exposure level, the Main Central thrust juxtaposes a hanging-wall flat in Greater Himalayan rocks with a footwall flat in Lesser Himalayan rocks of the Ramgarh thrust sheet, which is the roof thrust of a large Lesser Himalayan duplex. Sequential emplacement of the Main Central (early Miocene) and Ramgarh (middle Miocene) thrust sheets was followed by insertion of thrust sheets within the Lesser Himalayan duplex and folding of the Main Central and Ramgarh thrusts during late Miocene‐ Pliocene time. Thorium-lead (Th-Pb) ages of monazite inclusions in garnets from central Nepal record the timing of coeval, progressive metamorphism of Lesser Himalayan rocks in the footwall of the Main Central thrust. Although this model does not rule out minor, late-stage reactivation of the Main Central thrust, major late Miocene reactivation is not required.
A Review of the Theoretical Basis, Effects, and Cost Effectiveness of Online Smoking Cessation Interventions in the Netherlands: A Mixed-Methods Approach

Background Tobacco smoking is a worldwide public health problem. In 2015, 26.3% of the Dutch population aged 18 years and older smoked, 74.4% of them daily. More and more people have access to the Internet worldwide; approximately 94% of the Dutch population have online access. Internet-based smoking cessation interventions (online cessation interventions) provide an opportunity to tackle the scourge of tobacco. Objective The goal of this paper was to provide an overview of online cessation interventions in the Netherlands, while exploring their effectivity, cost effectiveness, and theoretical basis. Methods A mixed-methods approach was used to identify Dutch online cessation interventions, using (1) a scientific literature search, (2) a grey literature search, and (3) expert input. For the scientific literature, the Cochrane review was used and updated by two independent researchers (n=651 identified studies), screening titles, abstracts, and then full-text studies between 2013 and 2016 (CENTRAL, MEDLINE, and EMBASE). For the grey literature, the researchers conducted a Google search (n=100 websites), screening for titles and first pages. Including expert input, this resulted in six interventions identified in the scientific literature and 39 interventions via the grey literature. Extracted data included effectiveness, cost effectiveness, theoretical factors, and behavior change techniques used. Results Overall, many interventions (45 identified) were offered. Of the 45 that we identified, only six that were included in trials provided data on effectiveness. Four of these were shown to be effective and cost effective. In the scientific literature, 83% (5/6) of these interventions included changing attitudes, providing social support, increasing self-efficacy, motivating smokers to make concrete action plans to prepare their attempts to quit and to cope with challenges, supporting identity change and advising on changing routines, coping, and medication use. In all, 50% (3/6) of the interventions included a reward for abstinence. Interventions identified in the grey literature were less consistent, with inclusion of each theoretical factor ranging from 31% to 67% and of each behavior change technique ranging from 28% to 54%. Conclusions Although the Internet may provide the opportunity to offer various smoking cessation programs, the user is left bewildered as far as efficacy is concerned, as most of these data are not available nor offered to the smokers. Clear regulations about the effectiveness of these interventions need to be devised to avoid disappointment and failed quitting attempts. Thus, there is a need for policy regulations to regulate the proliferation of these interventions and to foster their quality in the Netherlands.
Monitoring and predicting the 2007 U.S. drought

Severe droughts developed in the West and Southeast of the U.S. starting early in 2007. The development of the droughts is well monitored and predicted by our model‐based Drought Monitoring and Prediction System (DMAPS). Using the North America Land Data Assimilation System (NLDAS) realtime meteorological forcing and the Variable Infiltration Capacity (VIC) land surface model, DMAPS is capable of providing a quantitative assessment of the drought in near realtime. Using seasonal climate forecasts from NCEP's Climate Forecast System (CFS) as one input, DMAPS successfully predicted the evolution of the droughts several months in advance. The realtime monitoring and prediction of drought with the system will provide invaluable information for drought preparation and drought impact assessment at national and local scales.
New ultra high density EPROM and flash EEPROM with NAND structure cell

In order to realize ultra high density EPROM and Flash EEPROM, a NAND structure cell is proposed. This new structure is able to shrink cell size without scaling of device dimensions. The NAND structure cell realizes a cell as small as 6.43 µm2using 1.0 µm design rule. As a result, cell area per bit can be reduced by 30% compared with that of a 4M bit EPROM using the conventional structure and the same design rule. It is confirmed that each bit in a NAND cell is able to be programmed selectively. This high performance NAND structure cell is applicable to high density nonvolatile memories as large as 8M bit EPROM and Flash-EEPROM or beyond.
Does the Experience of Electroconvulsive Therapy Improve Awareness and Perceptions of Treatment Among Relatives of Patients?

Objective: Evidence suggests that the actual experience of electroconvulsive therapy (ECT) has a positive impact on perceptions regarding the treatment among patients and their relatives. This assumption was tested by comparing relatives of patients treated with ECT with those of patients treated by other means. Design: Knowledge about and attitudes toward ECT were assessed using specifically designed questionnaires among 206 relatives of patients who were undergoing psychiatric treatment but had never received ECT (non-ECT group). The results were compared with those obtained among 77 relatives of patients who had undergone the treatment (ECT-treated group). Results: The relatives of the ECT-treated group were more likely to have acquired their information about ECT from physicians, whereas relatives of the non-ECT group usually relied on the media for this purpose. The relatives who obtained their information from physicians were more aware and more positive about ECT than those who obtained their information from the media. Knowledge about ECT was greater among relatives of the ECT-treated group than those of the non-ECT group. The relatives of the ECT recipients had significantly more positive attitudes toward the treatment, whereas the relatives of the non-ECT group were more often either ambivalent about ECT or critical of the treatment. Conclusions: Although the groups differed on certain clinical and demographic variables, these differences were unlikely to have influenced the results significantly. Thus, it was possible to conclude that sharing the experience of ECT with the patient had a significant and positive impact on the relative's knowledge and attitudes concerning the treatment.
The Role of Nrf2-Mediated Pathway in Cardiac Remodeling and Heart Failure

Heart failure (HF) is frequently the consequence of sustained, abnormal neurohormonal, and mechanical stress and remains a leading cause of death worldwide. The key pathophysiological process leading to HF is cardiac remodeling, a term referring to maladaptation to cardiac stress at the molecular, cellular, tissue, and organ levels. HF and many of the conditions that predispose one to HF are associated with oxidative stress. Increased generation of reactive oxygen species (ROS) in the heart can directly lead to increased necrosis and apoptosis of cardiomyocytes which subsequently induce cardiac remodeling and dysfunction. Nuclear factor-erythroid-2- (NF-E2-) related factor 2 (Nrf2) is a transcription factor that controls the basal and inducible expression of a battery of antioxidant genes and other cytoprotective phase II detoxifying enzymes that are ubiquitously expressed in the cardiovascular system. Emerging evidence has revealed that Nrf2 and its target genes are critical regulators of cardiovascular homeostasis via the suppression of oxidative stress, which is the key player in the development and progression of HF. The purpose of this review is to summarize evidence that activation of Nrf2 enhances endogenous antioxidant defenses and counteracts oxidative stress-associated cardiac remodeling and HF.
Aerodynamic Leidenfrost effect

When deposited on a plate moving quickly enough, any liquid can levitate as it does when it is volatile on a very hot solid (Leidenfrost effect). In the aerodynamic Leidenfrost situation, air gets inserted between the liquid and the moving solid, a situation that we analyze. We observe two types of entrainment. (i) The thickness of the air gap is found to increase with the plate speed, which is interpreted in the Landau-Levich-Derjaguin frame: Air is dynamically dragged along the surface and its thickness results from a balance between capillary and viscous effects. (ii) Air set in motion by the plate exerts a force on the levitating liquid. We discuss the magnitude of this aerodynamic force and show that it can be exploited to control the liquid and even to drive it against gravity.
IL-33 Reverses an Obesity-Induced Deficit in Visceral Adipose Tissue ST2+ T Regulatory Cells and Ameliorates Adipose Tissue Inflammation and Insulin Resistance

Obesity is associated with insulin resistance and inflammation thought to be caused by a visceral adipose tissue (VAT)–localized reduction in immunoregulatory cells and increase in proinflammatory immune cells. We previously found that VAT regulatory T cells (Tregs) normally express high levels of IL-10 and that expression of this cytokine in VAT Tregs is specifically reduced in mice fed a high-fat diet. In this study, we further investigated the phenotype of VAT Tregs and found that the majority of IL-10–expressing Tregs in the VAT of lean mice also expressed the ST2 chain of the IL-33R. In addition to high expression of IL-10, ST2+ Tregs in lean VAT expressed higher proportions of Th2-associated proteins, including GATA3 and CCR4, and Neuropillin-1 compared with ST2− Tregs. The proportion of ST2+ Tregs in VAT was severely diminished in obese mice that had been fed a high-fat/sucrose diet, and this effect could be completely reversed by treatment with IL-33. IL-33 treatment also reversed VAT inflammation in obese mice and resulted in a reduction of hyperinsulinemia and insulin resistance. These data suggest that IL-33 contributes to the maintenance of the normal pool of ST2+ Tregs in the VAT, and that therapeutic administration of IL-33 results in multiple anti-obesity effects, including the reversal of VAT inflammation and alleviation of insulin resistance.