Miracle-dz/UniFAR-FTUs huggingface dataset:
Journal of Theoretical and Applied Information Technology Differential Evolution Based Optimal Reactive Power Dispatch for Voltage Stability Enhancement

Reactive power dispatch (RPD) is one of the important tasks in the operation and control of power system. This paper presents a Differential Evolution (DE)-based approach for solving optimal reactive power dispatch including voltage stability limit in power systems. The monitoring methodology for voltage stability is based on the L-index of load buses. The objective is to minimize the real power loss subjected to limits on generator real and reactive power outputs, bus voltages, transformer taps and shunt power control devices such as SVCs. The proposed algorithm has been applied to IEEE 30-bus system to find the optimal reactive power control variables while keeping the system under safe voltage stability limit and is found to be effective for this task. The optimal reactive power allocation results obtained using DE are compared with other methods. It is shown that the objective function value is less than those of other methods.
Versatile Processor for GF(pm) Arithmetic for use in Cryptographic Applications

There has been a lot of research in recent years into cryptographic applications over GF(2m), GF(pm), p ges 2 and, GF(p), p large prime. In this paper a general architecture for a cryptographic processor capable of handling operations over any field, and the software developed to generate it, were introduced. The processor presented implements a ROM instruction set to simplify control of the system and reduce hardware complexity. The post place and route results for a number of generated elliptic curve processors were presented
Soft tissue and bone penetration abilities of daptomycin in diabetic patients with bacterial foot infections.

OBJECTIVES In the attempt to overcome increasing glycopeptide- and methicillin-resistant soft tissue infections, daptomycin is presently considered as an attractive alternative to the class of glycopeptides. However, daptomycin dosing and its ability to penetrate into inflamed target tissues are still a matter of controversy. Thus, in the present investigation, we set out to evaluate daptomycin's ability to penetrate into inflamed subcutaneous adipose tissue and bone in diabetic patients presenting with severe bacterial foot infection. PATIENTS AND METHODS The microdialysis technique was utilized to collect interstitial space fluid from inflamed subcutaneous adipose tissue and metatarsal bone. Plasma and unaffected subcutaneous adipose tissue served as reference compartments. Serial sampling of specimens at steady-state was performed from 0 to 8 h post-dose in five patients (Group A) and from 8 to 16 h after study drug administration in another group of four patients (Group B). In all subjects, daptomycin was administered intravenously once daily at a dosage of 6 mg/kg body weight for 4 consecutive days at minimum. RESULTS Equilibrium between free tissue and plasma concentrations was achieved approximately 2 h post-infusion. Under steady-state conditions, the degree of tissue penetration was assessed by the calculation of the ratio of free (f) AUC of daptomycin in plasma to the fAUC in tissues. The mean ratios of the fAUC0-16 tissue to the fAUC0-16 plasma were 1.44, 0.98 and 1.08 for healthy tissue, inflamed subcutaneous adipose tissue and bone, respectively. The corresponding ratios of the fAUCs from 0 to 24 h were 1.54, 1.06 and 1.17, respectively. CONCLUSIONS With the reservation that pharmacokinetic-pharmacodynamic targets for daptomycin in tissues are currently not established, we conclude that daptomycin given at intravenous doses of 6 mg/kg body weight once daily may be considered an effective treatment regimen in diabetic patients suffering from bacterial foot infection and osteomyelitis.
Protein tyrosine phosphatase PTPN22 is dispensable for dendritic cell antigen processing and promotion of T-cell activation by dendritic cells

The PTPN22R620W single nucleotide polymorphism increases the risk of developing multiple autoimmune diseases including type 1 diabetes, rheumatoid arthritis and lupus. PTPN22 is highly expressed in antigen presenting cells (APCs) where the expression of the murine disease associated variant orthologue (Ptpn22R619W) is reported to dysregulate pattern recognition receptor signalling in dendritic cells (DCs) and promote T-cell proliferation. Because T-cell activation is dependent on DC antigen uptake, degradation and presentation, we analysed the efficiency of these functions in splenic and GM-CSF bone marrow derived DC from wild type (WT), Ptpn22-/- or Ptpn22R619W mutant mice. Results indicated no differential ability of DCs to uptake antigen via macropinocytosis or receptor-mediated endocytosis. Antigen degradation and presentation was also equal as was WT T-cell conjugate formation and subsequent T-cell proliferation. Despite the likely presence of multiple phosphatase-regulated pathways in the antigen uptake, processing and presentation pathways that we investigated, we observed that Ptpn22 and the R619W autoimmune associated variant were dispensable. These important findings indicate that under non-inflammatory conditions there is no requirement for Ptpn22 in DC dependent antigen uptake and T-cell activation. Our findings reveal that perturbations in antigen uptake and processing, a fundamental pathway determining adaptive immune responses, are unlikely to provide a mechanism for the risk associated with the Ptpn22 autoimmune associated polymorphism.
A Linear Programming Approach to the Synthesis of Fixed-Structure Controllers

This paper describes a new approach to the synthesis of fixed-structure and fixed-order controllers. Such controllers are required in many practical applications. A broad class of fixed-structure controller synthesis problems can be reduced to the determination of a real controller parameter vector (or simply, a controller) <i>K</i>=(<i>k</i> <sub>1</sub>, <i>k</i> <sub>2</sub>, . , <i>k</i> <sub>t</sub>), so that a given set of real or complex polynomials of the form <i>P</i>(<i>s</i>,<i>K</i>):=<i>Po</i>(<i>s</i>)+<i>k</i> <sub>1</sub> <i>P</i> <sub>1</sub>(<i>s</i>)+. +<i>k</i> <sub>t</sub> <i>P</i> <sub>t</sub>(<i>s</i>) is Hurwitz. The stability of the closed-loop system requires a real characteristic polynomial to be Hurwitz, while several performance criteria can be satisfied by ensuring that a family of complex polynomials is Hurwitz. A novel feature of this paper is the exploitation of the interlacing property (IP) of Hurwitz polynomials to construct arbitrarily tight approximations of the set of stabilizing controllers. This is done by systematically constructing sets of linear inequalities in <i>K</i>. The union of the feasible sets of linear inequalities provides an approximation of the set of all controllers <i>K</i>, which render <i>P</i>(<i>s</i>, <i>K</i>) Hurwitz. As the number of sets of linear inequalities increases and approaches infinity, we show that the union of the feasible sets <i>approaches</i> the set of <i>all</i> stabilizing controllers of the desired structure. The main tools that are used in the construction of the sets of linear inequalities are the Hermite-Biehler theorem, Descartes' rule of signs, and its generalization. We provide examples of the applicability of the proposed methodology to the synthesis of fixed-order stabilizing controllers.
A Conserved Domain in the Coronavirus Membrane Protein Tail Is Important for Virus Assembly

ABSTRACT Coronavirus membrane (M) proteins play key roles in virus assembly, through M-M, M-spike (S), and M-nucleocapsid (N) protein interactions. The M carboxy-terminal endodomain contains a conserved domain (CD) following the third transmembrane (TM) domain. The importance of the CD (SWWSFNPETNNL) in mouse hepatitis virus was investigated with a panel of mutant proteins, using genetic analysis and transient-expression assays. A charge reversal for negatively charged E121 was not tolerated. Lysine (K) and arginine (R) substitutions were replaced in recovered viruses by neutrally charged glutamine (Q) and leucine (L), respectively, after only one passage. E121Q and E121L M proteins were capable of forming virus-like particles (VLPs) when coexpressed with E, whereas E121R and E121K proteins were not. Alanine substitutions for the first four or the last four residues resulted in viruses with significantly crippled phenotypes and proteins that failed to assemble VLPs or to be rescued into the envelope. All recovered viruses with alanine substitutions in place of SWWS residues had second-site, partially compensating, changes in the first TM of M. Alanine substitution for proline had little impact on the virus. N protein coexpression with some M mutants increased VLP production. The results overall suggest that the CD is important for formation of the viral envelope by helping mediate fundamental M-M interactions and that the presence of the N protein may help stabilize M complexes during virus assembly.
TESTING FOR EQUAL DISTRIBUTIONS IN HIGH DIMENSION

We propose a new nonparametric test for equality of two or more multivariate distributions based on Euclidean distance between sample elements. Several consistent tests for comparing multivariate distributions can be developed from the underlying theoretical results. The test procedure for the multisample problem is developed and applied for testing the composite hypothesis of equal distributions, when distributions are unspecified. The proposed test is universally consistent against all fixed alternatives (not necessarily continuous) with finite second moments. The test is implemented by conditioning on the pooled sample to obtain an approximate permutation test, which is distribution free. Our Monte Carlo power study suggests that the new test may be much more sensitive than tests based on nearest neighbors against several classes of alternatives, and performs particularly well in high dimension. Computational complexity of our test procedure is independent of dimension and number of populations sampled. The test is applied in a high dimensional problem, testing microarray data from cancer samples.
Lack of association between Helicobacter pylori infection and biliary tract diseases.

There are ambiguous results about the involvement of Helicobacter species in production of hepatobiliary diseases. This study was aimed to investigate any possible association between the presences of Helicobacter spp. , their genotypes and occurrence of different biliary diseases. Cultures of 102 bile samples for Helicobacter spp. did not show any growth, but the presence of Helicobacter genus specific DNA (16s rRNA gene) was detected in 3.92% of them. No significant association was found between development of the diseases and presence of the bacteria. All the Helicobacter genus positive samples belonged to H. pylori species and showed vacA+ (s1/m2), cagA- genotypes.
A new protocol and lower bounds for quantum coin flipping

We present a new protocol and two lower bounds for quantum coin flipping. In our protocol, no dishonest party can achieve one outcome with probability more than 0.75. Then, we show that our protocol is optimal for a certain type of quantum protocols. For arbitrary quantum protocols, we show that if a protocol achieves a bias of at most epsilon, it must use at least \Omega(\log \log \frac{1}{\epsilon}) rounds of communication. This implies that the parallel repetition fails for quantum coin flipping. (The bias of a protocol cannot be arbitrarily decreased by running several copies of it in parallel.)
A Comparison-Based Approach to Multicomputer System Diagnosis in Hybrid Fault Situations

A comparison-based system-level fault diagnosis model is considered. Provided the number of faulty units and the number of incorrect outcomes (in the sense that a fault-free unit evaluates a faulty one to be fault-free) do not exceed given bounds, the necessary and sufficient conditions for the comparison assignment to achieve correct and complete diagnosis are determined. An O(n mod E mod ) fault identification algorithm and optimal comparison assignments, in terms of minimum time of complete fault localization, are also proposed. The proposed diagnosis strategy can be performed concurrently with application tasks execution and the suitable comparison assignment can minimize the latency of fault identification. It makes the model more attractive for real-time applications. >
Analysis and Prediction of Mandelbugs in an Industrial Software System

Mandelbugs are faults that are triggered by complex conditions, such as interaction with hardware and other software, and timing or ordering of events. These faults are considerably difficult to detect with traditional testing techniques, since it can be challenging to control their complex triggering conditions in a testing environment. Therefore, it is necessary to adopt specific verification and/or fault-tolerance strategies for dealing with them in a cost-effective way. In this paper, we investigate how to predict the location of Mandelbugs in complex software systems, in order to focus V&V activities and fault tolerance mechanisms in those modules where Mandelbugs are most likely present. In the context of an industrial complex software system, we empirically analyze Mandelbugs, and investigate an approach for Mandelbug prediction based on a set of novel software complexity metrics. Results show that Mandelbugs account for a noticeable share of faults, and that the proposed approach can predict Mandelbug-prone modules with greater accuracy than the sole adoption of traditional software metrics.
Hinode EUV Imaging Spectrometer Observations of Solar Active Region Dynamics

The EUV Imaging Spectrometer (EIS) on the Hinode satellite is capable of measuring emission line center positions for Gaussian line profiles to a fraction of a spectral pixel, resulting in relative solar Doppler-shift measurements with an accuracy of a less than a km s(-1) for strong lines. We show an example of the application of that capability to an active region sit-and-stare observation in which the EIS slit is placed at one location on the Sun and many exposures are taken while the spacecraft tracking keeps the same solar location within the slit. For the active region examined (NOAA 10930), we find that significant intensity and Doppler-shift fluctuations as a function of time are present at a number of locations. These fluctuations appear to be similar to those observed in high-temperature emission lines with other space-borne spectroscopic instruments. With its increased sensitivity over earlier spectrometers and its ability to image many emission lines simultaneously, EIS should provide significant new constraints on Doppler-shift oscillations in the corona.
Application Timing of Complex Magnetic Fields Delineates Windows of Posttraining- Pretesting Vulnerability for Spatial and Motivational Behaviors in Rats

Male Wistar rats were trained in a two-session-per-day. non-matching-lo-sample radial maze task. During the 2hr interval between training sessions and testing sessions subjects were exposed for 60min to either sham fields or to a low intensity (200 to 500 nT) electromagnetic (EM) complex pattern whose electrical (current) equivalent has been shown to elicit long-term potentiation (LTP) in hippocampal slices. This pattern was applied either immediately following the training sessions or immediately antecedent to the testing sessions. Exposures to the experimental field immediately following the training session were associated with an impairment in spatial memory as inferred by increased commissions of reference errors. Exposures immediately prior to the testing session were associated with decreased motivation as inferred by a reduction in speed of responding. These results suggest that the timing of the presentation of patterned magnetic fields may differentially affect the representations of habit strength and drive within the consolidating memory trace.
Using machine learning to predict learner emotional state from brainwaves

Intelligent Tutoring Systems (ITS) learner model has progressively evolved. Initially composed of a cognitive module it was extended with a psychological module and an emotional module. The learner model still remains non-exhaustive. Methods of data collection on the cognitive and emotional state of the learner often lack precision and objectivity. In this paper we introduce an emomental agent. It interacts with an ITS to communicate the emotional state of the learner based upon his mental state. The mental state is obtained from the learner's brainwaves. The agent learns to predict the learner's emotions by using machine learning techniques.
The Feasibility of Cooperation to Comply with Land Use Change Obligations in the Marosszög Area of South Hungary

Abstract In many years excess water inundations generate a major obstacle to farming in the lowland part of Hungary, including the Marosszög area. Diverting water to large distances requires an infrastructure that is costly to develop and maintain. Alternatively, low-lying local land segments could be withdrawn from cultivation and utilized to collect the surplus water. The Ecological Focus Area (EFA) requirement of the EU points to the same direction: it requires that 5% of arable land is converted to other, ecologically more beneficial uses. During the research project it was tested if it is feasible to apply a novel economic policy instrument, an auction to trade land use change obligations, to achieve the EFA requirement in a cost effective way through the cooperation of farmers, while also creating a practical solution to manage the seasonal surplus water cover on land. The research was carried out in an interdisciplinary way: a dynamically coupled fully integrated hydrological model, including surface and subsurface modules, was applied by engineers to better understand the interconnections of land use, local hydrology and the role of the water diversion infrastructure; while a pilot auction exercise was conducted by economists with the participation of farmers to understand if cost reductions can be achieved through cooperation, as opposed to individual fulfilment of EFA obligations. The analysis also revealed which segments of the water diversion network are economic to maintain. It was confirmed that it is possible to improve local water management and satisfy the EFA requirements at a reduced cost if appropriate economic incentives are applied to trigger the cooperation of farmers.
Korean Red Ginseng Suppresses Metastasis of Human Hepatoma SK-Hep1 Cells by Inhibiting Matrix Metalloproteinase-2/-9 and Urokinase Plasminogen Activator

Korean red ginseng and ginsenosides have been claimed to possess wide spectrum of medicinal effects, of which anticancer effect is one. The present study was undertaken to investigate the antimetastatic effect of Korean red ginseng on human hepatoma as well as possible mechanisms. The inhibitory effect of the water extract of Korean red ginseng (WKRG) on the invasion and motility of SK-Hep1 cells was evaluated by the Boyden chamber assay in vitro. Without causing cytotoxicity, WKRG exerted a dose-dependent inhibitory effect on the invasion and motility, but not adhesion, of highly metastatic SK-Hep1 cells. Zymography analyses revealed significant downregulating effects on MMP-2, MMP-9, and uPA activities in SK-Hep1 cells. Western blot analyses also showed that WKRG treatment caused dose-dependent decreases in MMP-2 and MMP-9 protein expressions. Moreover, WKRG increased the levels of TIMP-1, TIMP-2, and PAI-1. The present study not only demonstrated that invasion and motility of cancer cells were inhibited by WKRG, but also indicated that such effects were likely associated with the decrease in MMP-2/-9 and uPA expressions of SK-Hep1 cells.
Hole Filling Through Photomontage

To fill holes in photographs of structured, man made environments, we propose a technique which automatically adjusts and clones large image patches that have similar structure. These source patches can come from elsewhere in the same image, or from other images shot from different perspectives. Two significant developments of this work are the ability to automatically detect and adjust source patches whose macrostructure is compatible with the hole region, and alternately, to interactively specify a user's desired search regions. In contrast to existing photomontage algorithms which either synthesize microstructure or require careful user interaction to fill holes, our approach handles macrostructure with an adjustable degree of automation.
Passive Mitigation of Aero-Induced Mechanical Jitter of Flat-Window Turrets

Extensive experimental studies of mechanical vibrations or jitter imposed by a complex flow on a turret with a flat-window aperture were performed. The main goal of this investigation was to test passive flow control, such as pins upstream of the flat window and to document their impact on an overall turret jitter for different azimuthal angles of 73, 90, and 125 degrees. Local measurements of unsteady pressure on the surface of the turret for all tested configurations were conducted. Also, independent measurements of the turret jitter were conducted using a turret-mounted 3-axis accelerometer, three load cells placed on the base of the turret and a Malley probe, which measured laser beam deflections off a mirror attached to the flat window. It was shown that small and medium pins arranged in a single row were the most effective configurations in reducing the overall jitter of the turret. The physical mechanism of the flow control effect on the turret jitter is proposed and discussed. Finally, a finite-element model was built to predict turret jitter. Using experimentally-obtained unsteady pressure, the model confirmed the mitigation effect of the pin configurations.
Transcranial Doppler and Near-Infrared Spectroscopy Can Evaluate the Hemodynamic Effect of Carotid Artery Occlusion

Background and Purpose— Cerebral hemodynamic and metabolic changes can compensate for the decrease in cerebral blood flow occurring in patients with carotid occlusive disease. At present, a complete assessment of the cerebral adaptive status is only possible with positron-emission tomography. Near-infrared spectroscopy (NIRS) is a noninvasive technique that, providing a real time assessment of fluctuations in cerebral hemoglobin, has been used to estimate the cerebral blood volume and to measure cerebral vasomotor reactivity (VMR). Moreover, NIRS technology, by allowing the absolute measurement of absorption and scattering coefficients of brain, can determine the oxyhemoglobin and deoxyhemoglobin concentrations in situ in the blood stream. Methods— In order to evaluate different aspects of the cerebral hemodynamic status, 27 subjects with symptomatic and asymptomatic carotid artery occlusion and 30 healthy subjects underwent a simultaneous examination by means of transcranial Doppler (TCD), able to reliably detect collateral circulation and VMR, and NIRS at rest condition and during CO2 reactivity test. Results— The main finding of this study was the demonstration of a difference between asymptomatic and symptomatic patients in terms of mean flow velocity increase (52.4% versus 21.0%; P <0.001) estimated by TCD and of hemoglobin saturation increase measured by NIRS (6.8% versus 3.8%; P =0.015). Conclusions— The opportunity to perform NIRS and TCD simultaneously provides useful information about both hemodynamic and metabolic cerebral adaptive status in patients with occlusive disease in a simple, noninvasive, and reliable way.