Miracle-dz/UniFAR-FTUs huggingface dataset:
Location of the Supraorbital and Infraorbital Foramen With References to the Soft Tissue Landmarks in a Chinese Population

Abstract The purpose of the current study was to determine the supraorbital foramen (SOF) and infraorbital foramen (IOF) based on soft tissue landmarks, to facilitate prediction of the location of this structure during facial surgery. Forty-two hemispheres of 21 adult cadavers (16 men and 5 women; aged 30–75 years) were dissected to expose the SOF and IOF. The locations of the SOF and IOF were evaluated with direct and photographic measurements. The data gained were analyzed by statistical method. The SOF localized 23.11 ± 2.35 mm superior and 9.48 ± 3.06 mm lateral to the angulus oculi medialis (AOM). The vertical angle from AOM to SOF was 68.3 (SD, 6.44) degrees. The SOF localized 24.81 (SD, 3.39) mm inferior and 10.89 (SD, 2.78) mm lateral to the AOM on the front view. The vertical angle from AOM to IOF was 66.5 (SD, 5.18) degrees. The SOF localized 11.22 (SD, 2.01) mm inferior and 6.09 (SD, 2.32) mm lateral to the ala of the nose (AL) on the front view. The vertical angle from AL to IOF was 61.7 (SD, 7.61) degrees. These results were a little different from the results of some other populations. We found the IOFs located on the point of one-fifth proportion distant to the ALs along the vertical direction distance from AL to SOF, whereas the AOMs located on the point of three-fifths proportion distant from the AL. Our results may provide more detailed information to predict the location of the SOFs and IOFs and help to prevent nerve or vessel damage.
Local haemorrhage induced by Bothrops jararaca venom: relationship to neurogenic inflammation.

We investigated morphological alterations induced by s.c. injection of 2.5 microg of Bothrops jararaca venom in rats. Intense disorganisation of collagen fibres was observed 1 min after the venom injection, particularly at regions near vessels and nerves. Mast cells were degranulated, and erythrocytes were seen leaving venules throughout the endothelial junctions. At this time, damaged endothelial cells were not observed. In rats envenomed as above, but immediately after cardiorespiratory failure induced by deep ether anaesthesia, alterations in the connective tissue structures, as previously described, were not observed. The mediation of this haemorrhage was investigated by injecting the venom into the foot pad of mice and compared to the mediation of oedema. Local haemorrhage was significantly reduced in mice pre-treated with capsaicin or guanethidine or submitted to a surgical section of sciatic and saphenous nerves. In these animals, oedema was not affected. Groups treated with methysergide or morphine showed both haemorrhage and oedema significantly reduced. Indomethacin or dexamethasone pre-treatments significantly reduced the oedema, but not the haemorrhage. Moreover, in animals treated with promethazine or mepyramine, oedema and haemorrhage were not affected. These data suggest that local haemorrhage induced by Bothrops jararaca venom is partially controlled by serotonin and neurohumoral mediators. Furthermore, results indicate that haemorrhage and oedema are mediated by different pharmacological systems.
Federal Reserve Bank of New York Staff Reports Procyclical Leverage and Value-at-risk

paper presents preliminary findings and is being distributed to economists and other interested readers solely to stimulate discussion and elicit comments. The views expressed in this paper are those of the authors and are not necessarily reflective of views at the Federal Reserve Bank of New York or the Federal Reserve System. Any errors or omissions are the responsibility of the authors.
How does the social distance between an employee and a manager affect employee competition for a reward

This study examines how employees internalize differences in social distance between themselves and their managers when they are competing for a reward given by the manager. In an employer/employee relationship, this difference in social distance between the employer and the various employees leads to a disadvantageous situation for the socially distant workers when raises, promotions, special considerations etc. are given. Since social distance is present in most organizations, understanding how employees work effort changes in response to changes in social distance is of upmost importance. In prior literature, this disadvantage has always been assumed/shown to lead to lower effort than the advantaged worker. The results partially back up this claim and show that females who are socially distant from their manager contribute much less than females who are socially closer or males regardless of the social distance.
Purkinje and Ventricular Activation Sequences of Canine Papillary Muscle: Effects of Quinidine and Calcium on the Purkinje‐Ventricular Conduction Delay

We have studied in vitro preparations of canine right and left papillary muscles to determine the excitation sequences of the Purkinje and ventricular cells, using both monopolar surface electrodes and intracellular microelectrodes. Our results show, for right papillary muscles, that the Purkinje layer covers the basal part of the muscle, and that activation from the right bundle branch propagates over all of the Purkinje layer, but directly activates the underlying ventricular layer only at specific junctional sites. Left papillary muscles have attachments to both apical and basal Purkinje strands and the Purkinje layer covers the entire muscle, but, as for right papillary muscles, activation from the Purkinje layer to the ventricular layer occurs only at basal junctional sites. Antidromic conduction in papillary muscles (propagation from the ventricular layer to the Purkinje layer) can occur at regions other than the specific sites through which the Purkinje layer activates the ventricular layer. At the identified junctional sites, the Purkinje cell action potential duration is significantly shorter than in the free-running strand, but it remains longer than that of the ventricular cells. The time delay at the junctional sites is increased by quinidine, increased calcium concentration, and increased pacing frequency.
Oscillations and temporal signalling in cells

The development of new techniques to quantitatively measure gene expression in cells has shed light on a number of systems that display oscillations in protein concentration. Here we review the different mechanisms which can produce oscillations in gene expression or protein concentration using a framework of simple mathematical models. We focus on three eukaryotic genetic regulatory networks which show ‘ultradian’ oscillations, with a time period of the order of hours, and involve, respectively, proteins important for development (Hes1), apoptosis (p53) and immune response (NF-κB). We argue that underlying all three is a common design consisting of a negative feedback loop with time delay which is responsible for the oscillatory behaviour.
Single sample modal identification of a nonstationary stochastic process

Gauss-Markov processes excited by nonstationary noises are encountered in the modeling of vibrating systems. We prove that the classical instrumental variable method, as well as the Ho-Kalman realization algorithm, for identifying the pole part (modal characteristics) of the model, are consistent when used on a single sample of the (nonstationary) signal.
Does timing of adjuvant chemotherapy for early breast cancer influence survival?

PURPOSE Theoretically, patients with early breast cancer might benefit from starting adjuvant chemotherapy soon after surgery, and this would have important clinical implications. We have addressed this question from a large, single-center database in which the majority of patients received anthracyclines. PATIENTS AND METHODS A total of 1161 patients from a prospectively maintained database treated with adjuvant chemotherapy for early breast cancer at the Royal Marsden Hospital (London, United Kingdom), including 686 (59%) receiving anthracyclines, were retrospectively analyzed. The disease-free survival (DFS) and overall survival (OS) of the 368 patients starting chemotherapy within 21 days of surgery (group A) were compared with those of the 793 patients commencing chemotherapy >or= 21 days after surgery (group B). Median follow-up time was 39 months (range, 12 to 147 months). RESULTS No significant difference in 5-year DFS was found between the two groups overall (70% for group A v 72% for group B; P =.4) or in any subgroup. Likewise, there was no difference in 5-year OS (82% for group A v 84% for group B; P =.2) or when the interval to the start of chemotherapy was considered as a continuous variable (P =.4). CONCLUSION We have been unable to identify any significant survival benefit from starting adjuvant chemotherapy early after surgery, either overall or in any subset of patients.
Ischemia-Reperfusion Injury and Ischemic-Type Biliary Lesions following Liver Transplantation

Ischemia-reperfusion (I-R) injury after liver transplantation (LT) induces intra- and/or extrahepatic nonanastomotic ischemic-type biliary lesions (ITBLs). Subsequent bile duct stricture is a significant cause of morbidity and even mortality in patients who underwent LT. Although the pathogenesis of ITBLs is multifactorial, there are three main interconnected mechanisms responsible for their formation: cold and warm I-R injury, injury induced by cytotoxic bile salts, and immunological-mediated injury. Cold and warm ischemic insult can induce direct injury to the cholangiocytes and/or damage to the arterioles of the peribiliary vascular plexus, which in turn leads to apoptosis and necrosis of the cholangiocytes. Liver grafts from suboptimal or extended-criteria donors are more susceptible to cold and warm I-R injury and develop more easily ITBLs than normal livers. This paper, focusing on liver I-R injury, reviews the risk factors and mechanisms leading to ITBLs following LT.
Turbulent airflow at young sea states with frequent wave breaking events: Large-eddy simulation

AbstractA neutrally stratified turbulent airflow over a very young sea surface at a high-wind condition was investigated using large-eddy simulations. In such a state, the dominant drag at the sea surface occurs over breaking waves, and the relationship between the dominant drag and local instantaneous surface wind is highly stochastic and anisotropic. To model such a relationship, a bottom boundary stress parameterization was proposed for the very young sea surface resolving individual breakers. This parameterization was compared to the commonly used parameterization for isotropic surfaces. Over both the young sea and isotropic surfaces, the main near-surface turbulence structure was wall-attached, large-scale, quasi-streamwise vortices. Over the young sea surface, these vortices were more intense, and the near-surface mean velocity gradient was smaller. This is because the isotropic surface weakens the swirling motions of the vortices by spanwise drag. In contrast, the young sea surface exerts little sp.
Survival in HIV-Infected Patients after a Cancer Diagnosis in the cART Era: Results of an Italian Multicenter Study

Objectives We studied survival and associated risk factors in an Italian nationwide cohort of HIV-infected individuals after an AIDS-defining cancer (ADC) or non-AIDS-defining cancer (NADC) diagnosis in the modern cART era. Methods Multi-center, retrospective, observational study of HIV patients included in the MASTER Italian Cohort with a cancer diagnosis from January 1998 to September 2012. Malignancies were divided into ADC or NADC on the basis of the Centre for Disease Control-1993 classification. Recurrence of cancer and metastases were excluded. Survivals were estimated according to the Kaplan-Meier method and compared according to the log-rank test. Statistically significant variables at univariate analysis were entered in a multivariate Cox regression model. Results Eight hundred and sixty-six cancer diagnoses were recorded among 13,388 subjects in the MASTER Database after 1998: 435 (51%) were ADCs and 431 (49%) were NADCs. Survival was more favorable after an ADC diagnosis than a NADC diagnosis (10-year survival: 62.7%±2.9% vs. 46%±4.2%; p = 0.017). Non-Hodgkin lymphoma had lower survival rates than patients with Kaposi sarcoma or cervical cancer (10-year survival: 48.2%±4.3% vs. 72.8%±4.0% vs. 78.5%±9.9%; p<0.001). Regarding NADCs, breast cancer showed better survival (10-year survival: 65.1%±14%) than lung cancer (1-year survival: 28%±8.7%), liver cancer (5-year survival: 31.9%±6.4%) or Hodgkin lymphoma (10-year survival: 24.8%±11.2%). Lower CD4+ count and intravenous drug use were significantly associated with decreased survival after ADCs or NADCs diagnosis. Exposure to cART was found to be associated with prolonged survival only in the case of ADCs. Conclusions cART has improved survival in patients with an ADC diagnosis, whereas the prognosis after a diagnosis of NADCs is poor. Low CD4+ counts and intravenous drug use are risk factors for survival following a diagnosis of ADCs and Hodgkin lymphoma in the NADC group.
Važnost obiteljskog podrijetla i roda za uspjeh iz matematike i odabir srednje škole

U radu su prezentirani rezultati empirijskog istraživanja koje, oslonom na Bourdiea (1977.), ispituje povezanost rodnih, socioekonomskih i sociokulturnih karakteristika ucenika/ca s njihovim uspjehom iz matematike i izborom srednje skole. Istraživanje je provedeno na uzorku od 693 ucenika/ca 8. razreda osnovnih skola u Gradu Zagrebu i Zagrebackoj županiji. Rezultati pokazuju da ucenice imaju bolje ocjene iz matematike od ucenika te da cesce nego ucenici namjeravaju upisati gimnazije, ali znatno rjeđe strukovne skole sa zastupljenijom matematikom (tehnicke skole). Ucenici/e viseg ekonomskog i kulturnog statusa postižu bolji uspjeh iz matematike i cesce biraju srednje skole sa zastupljenijom nastavom matematike. Bolji uspjeh iz matematike najsnažnije predviđaju rod, obrazovanje roditelja, posjedovanje klasicne literature te pristup Internetu. Pri analiziranom odabiru srednje skole, odabir gimnazije je prvenstveno objasnjen kulturnim resursima obitelji ucenika/ca, dok je odabir tehnicke skole vise objasnjen rodom ucenika/ce. Dobiveni nalazi o rodnoj i socijalnoj diferencijaciji u skladu su s nalazima istraživanja u drugim zemljama.
Social Trust: Toward a Cosmopolitan Society

Preface Social Trust: Past Social Trust: An Introduction Social Trust: Traditional Interpretations Complexity and Social Trust Social Trust: Present Strategies for Simplicity, One: High Resource Demand, Individual Focus Strategies for Simplicity, Two: High Resource Demand, Community Focus Strategies for Simplicity, Three: Low Resource Demand, Individual Focus Strategies for Simplicity, Four: Low Resource Demand, Community Focus Social Trust: Future Social Trust Based on Cultural Values Narrative, Human Life, and Social Trust Social Trust: Moving from a Pluralistic to a Cosmopolitan Society References Index
Recurrent brief depression: 'nasty, brutish and short'

Overview of Recurrent Brief Depression including: Historical background, development of the concept of recurrent brief depression; The Zurich Study; Diagnostic criteria; results of further epedemiological studies; similarities and differences with major depression;distinction from bipolar illness, cyclothymia and dysthymia; pharmacological treatment; future research and conclusions.
Length of Stay: A Case of Northern Norway

Abstract Length of stay (LOS) is one of the most commonly used variables in visitor surveys. The economic theory of consumer behavior postulates that a rational consumer maximizes utility subject to his /her budgetary restrictions. The objective of this study was to combine socio-demographic and travel behavior variables in order to examine the determinants of LOS for northern Norway as a vacation destination. Using data generated from a cross-sectional survey of visitors, the study employed truncated negative binomial regression analysis to examine the relationship between LOS and selected determinants of LOS. The results indicated that not all demographic variables but gender of visitors and income influenced LOS. Motivation, perception of the destination (brand personality) and perceived experience value also exerted varying degrees of influence on LOS. Visitors perceiving northern Norway as wholesome, cheerful, charming and sporty/outdoorsy stayed longer in the destination. Further, those with strong social motivations and experiences also stayed longer. Subsequently, it is recommended that managers carry out goal-directed product development and promotion strategies for attractions in northern Norway.
Antecedents and Employee Outcomes of Line Managers' Perceptions of Enabling HR Practices

To learn more about the role of line managers in the implementation of HR practices, we propose and test a model of line managers' perceptions of enabling HR practices on the one hand and employee outcomes on the other. In a field study of 89 line managers and 631 employees, we observed that the relationship between line managers' perceptions of enabling HR practices and employees' intrinsic motivation, affective organizational commitment, and turnover intention was mediated by employees' perceived supervisor support. Line managers' perceptions of enabling HR practices, in turn, were predicted by line managers' perceived quality of the HR training they received. Theoretical and practical implications and directions for future research are discussed.
Bowen's disease with invasive carcinoma showing sweat gland differentiation

A 75‐year‐ear‐old Japanese woman presented an erythematous macular lesion on the flexor aspect of her left wrist. A reddish nodule, 4 mm in diameter, was observed at the medial portion of the macule. The macular lesion was histologically confirmed to be a typical Bowen's disease. The nodular lesion was composed of intradermal solid nests of bowenoid neoplastic cells, and in some areas of the dermal component, prominent gland‐like structures were observed. Immunohistochemically, most neoplastic cells of the intradermal solid nests were positive with S‐100 protein, and the cells lining the gland‐like structures along with amorphous material within the lumens were positive with carcinoembryonic antigen. Judging from these findings, this case was diagnosed as Bowen's disease with invasive carcinoma, whose dermal component showed sweat gland differentiation not only morphologically but also immunohistochemically.
DNA polymorphisms of the apolipoprotein B gene (XbaI, EcoRI, and MspI RFLPs) in Norwegians at risk of atherosclerosis and healthy controls.

OBJECTIVES Apo B is the exclusive protein constituent of LDL and is ligand on LDL, recognized and bound by the LDL receptor. Several restriction fragment length polymorphisms (RFLPs) of the apo B gene have been shown to be associated with variation in serum lipid levels in different populations. In this study we sought to determine the frequency of XbaI, EcoRI, and MspI polymorphisms and the haplotypes generated by these three polymorphic sites of the apo B gene and their influence on lipid levels in a sample of Norwegian subjects at risk of atherosclerosis and healthy control subjects. METHODS AND RESULTS 108 White Norwegians at risk of atherosclerosis (cases) and 64 healthy individuals (controls) were examined for possible association between the alleles at the XbaI (X), EcoRI (R), and MspI (M) polymorphic restriction sites of the apolipoprotein B gene and serum lipid levels. The frequency of the M allele (absence of restriction site) was significantly higher in cases with high total cholesterol (TC), high low-density lipoprotein cholesterol (LDLC), and high apolipoprotein B (apo B) than in controls with normal TC, LDLC, and apo B (P < 0.04, P < 0.02, and P < 0.01, respectively). The frequencies of apo B genotypes detected with XbaI, EcoRI, and MspI did not differ significantly between cases and control subjects. A significant association between MspI genotypes and TC (P < 0.02), LDLC (P = 0.03), and apo B (P = 0.001) was observed only in cases. However, cases with the genotype M+/M+ had the lowest and those with the genotype M+/M- had the highest levels of serum TC, LDLC, and apo B. We did not observe any significant association between the alleles or genotypes detected with XbaI or EcoRI and serum lipid levels. In cases, genotypes defined by EcoRI and MspI RFLP paired loci differed significantly for apo B (chi 2 = 19; P = 0.007) but not for other blood lipids. EcoRI and MspI RFLPs change glutamic acid (Glu) 4154 to lysine (Lys) and arginine (Arg) 3611 to glutamine (Gln), respectively, which lie near the low density lipoprotein receptor binding region of apo B. Haplotypes containing "Lys/Arg Lys/Arg" (all basic amino acids) in cases were associated with low serum TC, LDLC, and apo B. In individuals at risk of atherosclerosis the concentration of serum lipids tends to be inversely related to the number of lysine and arginine. CONCLUSION We conclude that variations in the apo B gene, resulting in changes of charged amino acids, affect the circulating blood lipids and that these may contribute to the risk of atherosclerosis.
Self‐Ratings of Memory versus Psychometric Ratings of Memory and Hypochondriasis

ABSTRACT: Self‐ratings of memory were studied in 69 institutionalized women. The patients also were evaluated by means of three screening tests for organic brain syndrome (OBS) and a hypochondriasis scale. A negative correlation existed between self‐rating of memory and actual memory as measured by the screening tests for OBS, but it was significant (p < .05) for only one of the tests. There was also a negative correlation (p < .01) between memory rating and scores on the hypochondriasis scale. Therefore, clinicians should not take patients' memory complaints as valid indicators of OBS, but as possible indicators of hypochondriasis.
Inactivation of key factors of the plasma proteinase cascade systems by Bacteroides gingivalis

The effect of Bacteroides gingivalis W83 on various key components of the human plasma proteinase cascade systems was studied. When purified C1-inhibitor was incubated with the bacterium, the inhibitor was rapidly inactivated by limited proteolytic cleavage. In citrated whole plasma, C1-inhibitor, antithrombin, plasminogen, prekallikrein, prothrombinase complex, the clotting factor X, and most of the alpha 2-antiplasmin were functionally eliminated after 30 min of incubation with the bacterium. Fibrinogen disappeared from the plasma almost immediately upon mixing with the bacterial suspension. In contrast, there was no appreciable decrease in the bulk of other plasma proteins, such as various transport proteins (albumin, prealbumin, transferrin) and immunoglobulins, during 4 h of incubation with the bacterium. Most of the observed effects can be assigned to the proteolytic activity of the bacterium itself, since there was little evidence for generation of intrinsic plasma proteinase activity, despite the loss of proteinase inhibitory activities. B. gingivalis W83 thus seems to be equipped with proteolytic enzyme systems which selectively recognize and rapidly inactivate the most important proteinase inhibitors and proenzymes present in human plasma. This bacterium therefore seems to be able to efficiently paralyze the host's various defenses against invading microorganisms.