Miracle-dz/UniFAR-FTUs huggingface dataset:
Quantifying Location Sociality

The emergence of location-based social networks provides an unprecedented chance to study the interaction between human mobility and social relations. This work is a step towards quantifying whether a location is suitable for conducting social activities, and the notion is named location sociality. Being able to quantify location sociality creates practical opportunities such as urban planning and location recommendation. To quantify a location's sociality, we propose a mixture model of HITS and PageRank on a heterogeneous network linking users and locations. By exploiting millions of check-in data generated by Instagram users in New York and Los Angeles, we investigate the relation between location sociality and several location properties, including location categories, rating and popularity. We further perform two case studies, i.e., friendship prediction and location recommendation, experimental results demonstrate the usefulness of our quantification.
Power efficient charge pump in deep submicron standard CMOS technology

A power efficient charge pump is proposed. The use of low voltage transistors and of a simple 2-phase clocking scheme allows the use of higher frequencies compared to conventional solutions, thus obtaining high current, high efficiency and small area. Measurements show good results for frequencies around 100MHz. Two testpatterns have been fabricated, one with three stages and one with five stages, in a 1.8V 0.18micro;m standard CMOS digital process (6 metals) with triple well. High voltage capacitors have been implemented using metal to metal parasitic capacitance.
Notoginsenoside R1 attenuates glucose-induced podocyte injury via the inhibition of apoptosis and the activation of autophagy through the PI3K/Akt/mTOR signaling pathway

Injury to terminally differentiated podocytes contributes ignificantly to proteinuria and glomerulosclerosis. The aim of this study was to examine the protective effects of notoginsenoside R1 (NR1) on the maintenance of podocyte number and foot process architecture via the inhibition of apoptosis, the induction of autophagy and the maintenance pf podocyte biology in target cells. The effects of NR1 on conditionally immortalized human podocytes under high glucose conditions were evaluated by determining the percentage apoptosis, the percentage autophagy and the expression levels of slit diaphragm proteins. Our results revealed that NR1 protected the podocytes against high glucose-induced injury by decreasing apoptosis, increasing autophagy and by promoting cytoskeletal recovery. The phosphoinositide 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling pathway was further investigated in order to elucidate the mechanisms responsible for the protective effects of NR1 on podocytes. Our data indicated that treatment with NR increased the phosphorylation levels of PI3K, Akt and mTOR, leading to the activation of the PI3K/Akt/mTOR signaling pathway in podocytes. To the best of our knowledge, this is the first in vitro study to demonstrate that NR1 protects podocytes by activating the PI3K/Akt/mTOR pathway.
STORIES FROM PLANET FOOTBALL AND SPORTSWORLD

The profile of sport journalism has increased as the scale and media profile of large-scale international sporting events have escalated. This article considers the ways in which sport journalists have responded to such changes. It concentrates upon the nature of sport journalists’ relationships with their sources; their relationship with gatekeepers; and the issue of collusion, between journalists themselves and journalists and their subjects and sources. Drawing upon extensive periods of participation and observation at the Olympic Games, the FIFA (men's) football World Cup, and international football club and national championships and tournaments, and citing in-depth interviews with a senior wires-based journalist, the authors examine the practices of the sport journalism profession. These are also discussed in the light of journalists’ own published accounts, memoirs and reflections, and the wider, limited literature of research into the professional culture of sport journalism. In conclusion, the article argues that traditional legacies of source relations combine with current trends in promotional culture to confirm the collusive dynamic, and in widespread cases to intensify the trivialisation of the subject matter of the sport journalist.
Correlation of Molecular Markers, Pfmdr1-N86Y and Pfcrt-K76T, with In Vitro Chloroquine Resistant Plasmodium falciparum, Isolated in the Malaria Endemic States of Assam and Arunachal Pradesh, Northeast India

The mechanism of chloroquine (CQ) resistance in Plasmodium falciparum is not clearly understood. However, CQ resistance has been shown to be associated with point mutations in Pfcrt and Pfmdr1. These genes encode for digestive vacuole transmembrane proteins Pfcrt and Pgh1, respectively. The present study was carried out to analyze the association of Pfcrt-K76T and Pfmdr1-N86Y mutations with CQ resistance in Northeast Indian P. falciparum isolates. 115 P. falciparum isolates were subjected to in vitro CQ sensitivity testing and PCR-RFLP analysis for the Pfmdr1-N86Y and Pfcrt-K76T mutations. 100 isolates of P. falciparum were found to be resistant to CQ by the in vitro susceptibility test (geometric mean EC50 2.21 µM/L blood) while 15 were found to be CQ sensitive (geometric mean EC50 0.32 µM/L blood). All the CQ resistant isolates showed the presence of Pfmdr1 and Pfcrt mutations. CQ sensitive isolates were negative for these mutations. Strong linkage disequilibrium was observed between the alleles at these two loci (Pfmdr1-N86Y and Pfcrt-K76T). The results indicate that Pfmdr1-N86Y and Pfcrt-K76T mutations can be used as molecular markers to identify CQ resistance in P. falciparum. The result necessitates the evaluation of CQ in vivo therapeutic efficacy in endemic areas for more effective malaria control strategies.
Adaptive Energy Storage Management in Green Wireless Networks

Time-varying wireless channel as well as the variability of renewable energy supply and energy prices are practically unknown in advance. To address such dynamic statistics of wireless networks, this letter develops an adaptive strategy inspired by combinatorial multiarmed bandit model for energy storage management and cost-aware coordinated load control at the base stations. The proposed strategy makes online foresighted decisions on the amount of energy to be stored in storage to minimize the average energy cost over long-time horizon. Simulation results validate the superiority of the proposed strategy over a recently proposed storage-free learning-based design.
Extended Minus-Strand DNA as Template for R-U5-Mediated Second-Strand Transfer in Recombinational Rescue of Primer Binding Site-Modified Retroviral Vectors

ABSTRACT We have previously demonstrated recombinational rescue of primer binding site (PBS)-impaired Akv murine leukemia virus-based vectors involving initial priming on endogenous viral sequences and template switching during cDNA synthesis to obtain PBS complementarity in second-strand transfer of reverse transcription (Mikkelsen et al., J. Virol. 70:1439–1447, 1996). By use of the same forced recombination system, we have now found recombinant proviruses of different structures, suggesting that PBS knockout vectors may be rescued through initial priming on endogenous virus RNA, read-through of the mutated PBS during minus-strand synthesis, and subsequent second-strand transfer mediated by the R-U5 complementarity of the plus strand and the extended minus-strand DNA acceptor template. Mechanisms for R-U5-mediated second-strand transfer and its possible role in retrovirus replication and evolution are discussed.
Informatik Minimal and Hyper-Minimal Biautomata

We compare deterministic finite automata (DFAs) and biautomata under the following two aspects: structural similarities between minimal and hyper-minimal automata, and computational complexity of the minimization and hyper-minimization problem. Concerning classical minimality, the known results such as isomorphism between minimal DFAs, and NL-completeness of the DFA minimization problem carry over to the biautomaton case. But surprisingly this is not the case for hyper-minimization: the similarity between almostequivalent hyper-minimal biautomata is not as strong as it is between almost-equivalent hyper-minimal DFAs. Moreover, while hyper-minimization is NL-complete for DFAs, we prove that this problem turns out to be computationally intractable, i.e., NP-complete, for biautomata.
Decreased Damage From Transient Focal Cerebral Ischemia by Transfusion of Zero-Link Hemoglobin Polymers in Mouse

Background and Purpose— Transfusion of large polymers of hemoglobin avoids the peripheral extravasation and hypertension associated with crosslinked tetrameric hemoglobin transfusion and may be more effective in rescuing brain from focal ischemia. Effects of transfusion of high-oxygen-affinity hemoglobin polymers of different weight ranges were determined. Methods— Hypervolemic exchange transfusion was performed during 2 hours of middle cerebral artery occlusion in mice. Results— Compared to transfusion with a 5% albumin solution or no transfusion, infarct volume was reduced 40% by transfusion of a 6% solution containing hemoglobin polymers in the nominal range 500 to 14 000 kDa. Infarct volume was not significantly reduced by transfusion of a lower concentration of 2% to 3% of this size range of polymers, 6% hemoglobin solutions without removal of polymers <500 kDa or >14000 kDa, or crosslinked hemoglobin tetramers with normal oxygen affinity. Exchange transfusion with the 6% solution of the 500 to 14 000 kDa hemoglobin polymers did not improve the distribution of cerebral blood flow during focal ischemia and, in mice without ischemia, did not affect flow to brain or other major organs. Conclusion— An intermediate size range of polymerized bovine hemoglobin possessing high oxygen affinity appears optimal for rescuing mouse brain from transient focal cerebral ischemia. A minimum concentration of a 6% solution is required, the rescue is superior to that obtained with crosslinked tetrameric hemoglobin possessing normal oxygen affinity, and tissue salvage is not associated with increased blood flow. This polymer solution avoids the adverse effects of severe renal and splanchnic vasoconstriction seen with crosslinked tetrameric hemoglobin.
Antioxidant vitamins intake and the risk of coronary heart disease: meta-analysis of cohort studies

Background Many epidemiological studies have reported that antioxidant vitamin intake from diet or supplements are associated with a lower risk of coronary heart disease (CH D), the findings are, however, inconsistent. We undertook a meta-analysis of cohort studies to examine the relations between antioxidant vitamins (vitamins C, E, and β-carotene) and CHD risk. Methods and results We included all the relevant cohort studies if they provided a relative risk and corresponding 95% confidence interval (CI) of CHD in relation to antioxidant vitamins intake from diet or supplement. Fifteen cohort studies were identified involving a total of 7415 incident CHD cases and 374488 participants with a median follow-up of approximately 10, 8.5, and 15 years for vitamins C, E, and β-carotene, respectively. Pooled estimates across studies were obtained by random-effects model. The potential sources of heterogeneity and publication bias were also estimated. For vitamins C, E, and β-carotene, a comparison of individuals in the top third with those in the bottom third of baseline value yielded a combined relative risk of 0.84 (95% CI, 0.73-0.95), 0.76 (95% CI, 0.63-0.89), and 0.78 (95% CI, 0.53-1.04), respectively. Subgroup analyses show that dietary intake of vitamins C and E and supplement use of vitamin E have an inverse association with CHD risk, but supplement use of vitamin C has no significant association with CHD risk. In the dose-response meta-analysis, each 30 mg/day increase in vitamin C, 30IU/day increase in vitamin E, and 1 mg/day increase in β-carotene yielded the estimated overall relative risk for CHD of 1.01 (95% CI, 0.99-1.02), 0.96 (95% CI, 0.94-0.99), and 1.00 (95% CI, 0.88-1.14), respectively. Conclusions Our findings in this meta-analysis suggest that an increase in dietary intake of antioxidant vitamins has encouraging prospects for possible CHD prevention.
Cognitive Psychology: A Student's Handbook

Introduction. Visual Perception: Basic Processes. Perception, Movement and Action. Object Recognition. Attention and Performance Limitations. Memory: Structure and Processes. Theories of Long-term Memory. Everyday Memory. Knowledge: Propositions and Images. Objects, Concepts and Categories. Speech Perception and Reading. Language Comprehension. Language Production. Puzzles and Expertise. Creativity and Analogy. Reasoning: Conditionals. Judgement and Decision Making. Cognition and Emotion. Present and Future.
Arthroscopic Hill-Sachs remplissage: a systematic review.

BACKGROUND Failure to address humeral osseous defects during arthroscopic stabilization surgery for glenohumeral instability leads to an increased rate of recurrence. Arthroscopic remplissage has been proposed as a treatment option for substantial Hill-Sachs lesions. The aim of this systematic review was to examine the outcomes of the remplissage procedure for the treatment of anterior glenohumeral instability of the shoulder with a humeral head defect. METHODS A systematic literature review was performed to evaluate the outcomes of arthroscopic Hill-Sachs remplissage. Studies that reported on patients who underwent arthroscopic infraspinatus tenodesis concomitant with a standard Bankart repair were included if they had relevant clinical outcomes and associated complications. The frequency-weighted mean was calculated for outcome measures that were similar across several studies. RESULTS Six studies fulfilled the inclusion criteria and were included in the review. The studies included 167 patients (mean age, 27.5 years) with a mean follow-up of 26.8 months (range, twelve to forty-three months). Patients had a frequency-weighted mean adjusted Rowe score of 36.1 preoperatively compared with 87.6 postoperatively (p < 0.001). In the studies with motion measurements, shoulder motion was not affected postoperatively (p > 0.05); mean forward elevation changed from 165.7° preoperatively to 170.3° postoperatively, and mean external rotation changed from 57.2° to 54.6°. Nine of 167 shoulders experienced an episode of recurrent glenohumeral instability (overall recurrence rate, 5.4%). CONCLUSIONS Postoperative clinical outcome scores were generally good to excellent following arthroscopic remplissage. No studies indicated a significant loss of shoulder motion following the procedure. The failure rate following Hill-Sachs remplissage compared favorably with previously published rates for patients without clinically important Hill-Sachs lesions who underwent arthroscopic Bankart repair alone. The overall complication rate across the studies was low, further supporting the use of this technique along with Bankart repair in the treatment of glenohumeral instability with a concurrent osseous defect of the humeral head.
Single Molecule Studies of Physiologically Relevant Telomeric Tails Reveal POT1 Mechanism for Promoting G-quadruplex Unfolding*

Human telomeres are composed of duplex TTAGGG repeats and a 3′ single-stranded DNA tail. The telomeric DNA is protected and regulated by the shelterin proteins, including the protection of telomeres 1 (POT1) protein that binds telomeric single-stranded DNA. The single-stranded tail can fold into G-quadruplex (G4) DNA. Both POT1 and G4 DNA play important roles in regulating telomere length homeostasis. To date, most studies have focused on individual quadruplexes formed by four TTAGGG repeats. Telomeric tails in human cells have on average six times as many repeats, and no structural studies have examined POT1 binding in competition with G4 DNA folding. Using single molecule atomic force microscopy imaging, we observed that the majority of the telomeric tails of 16 repeats formed two quadruplexes even though four were possible. The result that physiological telomeric tails rarely form the maximum potential number of G4 units provides a structural basis for the coexistence of G4 and POT1 on the same DNA molecule, which is observed directly in the captured atomic force microscopy images. We further observed that POT1 is significantly more effective in disrupting quadruplex DNA on long telomeric tails than an antisense oligonucleotide, indicating a novel POT1 activity beyond simply preventing quadruplex folding.
PENGARUH ASESMEN KINERJA DALAM MODEL PEMBELAJARAN ARIAS TERHADAP KEMAMPUAN PEMECAHAN MASALAH

Penelitian ini bertujuan mengetahui:(1) kemampuan pemecahan masalah peserta didik pada pembelajaran ARIAS dengan asesmen kinerja dan pembelajaran ARIAS mencapai ketuntasan; (2) perbedaan kemampuan pemecahan masalah peserta didik pada pembelajaran ARIAS dengan asesmen kinerja, pada pembelajaran ARIAS , dan pada pembelajaran ekspositori; (3) kemampuan pemecahan masalah peserta didik pada pembelajaran ARIAS dengan asesmen kinerja lebih baik dari pembelajaran ARIAS ; (4) kualitas pembelajaran, kinerja guru dan aktivitas peserta didik baik. Populasi penelitian ini adalah semua peserta didik kelas VIII MTsN Sumber, Rembang tahun pelajaran 2012/2013. Teknik sampel dalam penelitian ini cluster random sampling. Data diperoleh dengan metode tes dan metode observasi. Berdasarkan hasil penelitian disimpulkan bahwa: kemampuan pemecahan masalah peserta didik pada pembelajaran ARIAS dengan asesmen kinerja dan pembelajaran ARIAS tuntas, ada perbedaan kemampuan pemecahan masalah peserta didik pada pembelajaran ARIAS dengan asesmen kinerja, pembelajaran ARIAS , dan pembelajaran ekspositori; kemampuan pemecahan masalah peserta didik pada pembelajaran ARIAS dengan asesmen kinerja lebih baik daripada pembelajaran ARIAS ; kualitas pembelajaran, kinerja guru dan aktivitas peserta didik baik.
Physical Implications of the X-ray Properties of Galaxy Groups and Clusters

Within the standard framework of structure formation, where clusters and groups of galaxies are built up from the merging of smaller systems, the physical properties of the intracluster medium, such as the gas temperature and the total X-ray luminosity, are predicted to possess well defined self-similar scaling relations. Observed clusters and groups, however, show strong deviations from these predicted relations. We argue that these deviations are unlikely to be entirely due to observational biasses; we assume they are physically based, due to the presence of excess entropy in the intracluster medium in addition to that generated by accretion shocks during the formation of the cluster. Several mechanisms have been suggested as a means of generating this entropy. Focussing on those mechanisms that preheat the gas before it becomes a constituent of the virialized cluster environment, we present a simple, intuitive, physically motivated, analytic model that successfully captures the important physics associated with the accretion of high entropy gas onto group and cluster-scale systems. We use the model to derive the new relationships between the observable properties of clusters and groups of galaxies, as well as the evolution of these relations. These include the luminosity-temperature and luminosity-� relations, as well as the temperature distribution function and X-ray luminosity function. These properties are found to be a more accurate description of the observations than those predicted from the standard framework. Future observations that will further test the efficacy of the preheated gas scenario are also discussed.
Carboxypeptidases B of Anopheles gambiae as Targets for a Plasmodium falciparum Transmission-Blocking Vaccine

ABSTRACT Anopheles gambiae is the major African vector of Plasmodium falciparum, the most deadly species of human malaria parasite and the most prevalent in Africa. Several strategies are being developed to limit the global impact of malaria via reducing transmission rates, among which are transmission-blocking vaccines (TBVs), which induce in the vertebrate host the production of antibodies that inhibit parasite development in the mosquito midgut. So far, the most promising components of a TBV are parasite-derived antigens, although targeting critical mosquito components might also successfully block development of the parasite in its vector. We previously identified A. gambiae genes whose expression was modified in P. falciparum-infected mosquitoes, including one midgut carboxypeptidase gene, cpbAg1. Here we show that P. falciparum up-regulates the expression of cpbAg1 and of a second midgut carboxypeptidase gene, cpbAg2, and that this up-regulation correlates with an increased carboxypeptidase B (CPB) activity at a time when parasites establish infection in the mosquito midgut. The addition of antibodies directed against CPBAg1 to a P. falciparum-containing blood meal inhibited CPB activity and blocked parasite development in the mosquito midgut. Furthermore, the development of the rodent parasite Plasmodium berghei was significantly reduced in mosquitoes fed on infected mice that had been immunized with recombinant CPBAg1. Lastly, mosquitoes fed on anti-CPBAg1 antibodies exhibited reduced reproductive capacity, a secondary effect of a CPB-based TBV that could likely contribute to reducing Plasmodium transmission. These results indicate that A. gambiae CPBs could constitute targets for a TBV that is based upon mosquito molecules.
Fluid limit of generalized Jackson queueing networks with stationary and ergodic arrivals and service times

We use a sample-path technique to derive asymptotics of generalized Jackson queueing networks in the fluid scale; that is, when space and time are scaled by the same factor n. The analysis only presupposes the existence of long-run averages and is based on some monotonicity and concavity arguments for the fluid processes. The results provide a functional strong law of large numbers for stochastic Jackson queueing networks, since they apply to their sample paths with probability 1. The fluid processes are shown to be piecewise linear and an explicit formulation of the different drifts is computed. A few applications of this fluid limit are given. In particular, a new computation of the constant that appears in the stability condition for such networks is given. In a certain context of a rare event, the fluid limit of the network is also derived explicitly.