Miracle-dz/UniFAR-FTUs huggingface dataset:
Cognitive Aspects of Learning and Teaching Science.

This paper discusses the nature of cognitive research and its implications for learning and teaching science. In addition to needing adequate financial support, active involvement of scientists and educators, and education of teachers, two other factors should loom large in the development of new instructional materials in science and in the design of new instructional strategies. The first is cognitive research findings on teaching, learning, and problem solving. The second factor is the nature of science as it is practiced by scientists. The paper is divided into sections on research on learning and problem solving in science, lack of alignment between instructional practices and current views of learning, and factors necessary to bring about alignment between instructional practices and current views of learning. (Contains 115 references.) (MM) ******************************************************************************** Reproductions supplied by EDRS are the best that can be made from the original document. ******************************************************************************** Reproductions supplied by EDRS are the best that can be made from the original document. COGNITIVE ASPECTS OF LEARNING AND TEACHING SCIENCE
Efficient Policy Learning

We consider the problem of using observational data to learn treatment assignment policies that satisfy certain constraints specified by a practitioner, such as budget, fairness, or functional form constraints. This problem has previously been studied in economics, statistics, and computer science, and several regret-consistent methods have been proposed. However, several key analytical components are missing, including a characterization of optimal methods for policy learning, and sharp bounds for minimax regret. In this paper, we derive lower bounds for the minimax regret of policy learning under constraints, and propose a method that attains this bound asymptotically up to a constant factor. Whenever the class of policies under consideration has a bounded Vapnik-Chervonenkis dimension, we show that the problem of minimax-regret policy learning can be asymptotically reduced to first efficiently evaluating how much each candidate policy improves over a randomized baseline, and then maximizing this value estimate. Our analysis relies on uniform generalizations of classical semiparametric efficiency results for average treatment effect estimation, paired with sharp concentration bounds for weighted empirical risk minimization that may be of independent interest.
Buccodental health and oral mucositis. Clinical study in patients with hematological diseases.

OBJECTIVES The objective of the present study is to assess whether a good buccodental status (evaluated by means of dentogingival indices), is associated with a lower incidence and severity of oral mucositis in patients with hematological diseases who receive treatment with chemotherapy or bone marrow transplant. STUDY DESIGN The study was carried out on 97 patients admitted to the Hematology Service of the Hospital Duran y Reynals in Barcelona during 2002-2003. These patients received treatment with chemotherapy or conditioning prior to bone marrow transplant. A descriptive study was made, analyzing oral hygiene, one dental index, and two gingivales indices, and evaluating their relationship with the appearance of mucositis. RESULTS The patients with high plaque (PI) and gingival (GI) indices during chemotherapy presented a higher percentage of mucositis (77.4% and 65.7% respectively) against those who had little or no visible plaque. In the case of the PI, the differences were statistically significant (p=0.015). Likewise, patients who brushed their teeth 3 times/day presented mucositis in only 26.7% of cases, against those who did not brush, or brushed only once a day (65.9% and 68.4%), these differences also being statistically significant (p=0.013). The CAO showed similar results in patients with or without mucositis (7.59 and 7.03 respectively). CONCLUSIONS In our study, a good gingival status as well as good oral hygiene during chemoradiotherapy is associated with a lower incidence and severity of mucositis.
Chemotactic Signaling by an Escherichia coli CheA Mutant That Lacks the Binding Domain for Phosphoacceptor Partners

ABSTRACT CheA is a multidomain histidine kinase for chemotaxis in Escherichia coli. CheA autophosphorylates through interaction of its N-terminal phosphorylation site domain (P1) with its central dimerization (P3) and ATP-binding (P4) domains. This activity is modulated through the C-terminal P5 domain, which couples CheA to chemoreceptor control. CheA phosphoryl groups are donated to two response regulators, CheB and CheY, to control swimming behavior. The phosphorylated forms of CheB and CheY turn over rapidly, enabling receptor signaling complexes to elicit fast behavioral responses by regulating the production and transmission of phosphoryl groups from CheA. To promote rapid phosphotransfer reactions, CheA contains a phosphoacceptor-binding domain (P2) that serves to increase CheB and CheY concentrations in the vicinity of the adjacent P1 phosphodonor domain. To determine whether the P2 domain is crucial to CheA's signaling specificity, we constructed CheAΔP2 deletion mutants and examined their signaling properties in vitro and in vivo. We found that CheAΔP2 autophosphorylated and responded to receptor control normally but had reduced rates of phosphotransfer to CheB and CheY. This defect lowered the frequency of tumbling episodes during swimming and impaired chemotactic ability. However, expression of additional P1 domains in the CheAΔP2 mutant raised tumbling frequency, presumably by buffering the irreversible loss of CheAΔP2-generated phosphoryl groups from CheB and CheY, and greatly improved its chemotactic ability. These findings suggest that P2 is not crucial for CheA signaling specificity and that the principal determinants that favor appropriate phosphoacceptor partners, or exclude inappropriate ones, most likely reside in the P1 domain.
HUBUNGAN KETERAMPILAN MATEMATIKA DENGAN KEMAMPUAN MENYELESAIKAN SOAL FISIKA TERHADAP MISKONSEPSI SISWA PADA IMPULS MOMENTUM

Abstrak: Penelitian ini bertujuan untuk mengetahui apakah terdapat hubungan keterampilan matematika dengan kemampuan menyelesaikan soal fisika terhadap miskonsepsi siswa pada materi impuls momentum. Metode penelitian yang digunakan adalah analisis deskriptif korelasi. Sampel penelitian ini adalah 25 siswa. Instrumen penelitian yang dibuat berupa 5 soal esai mencakup tumbukan lenting sempurna dan tumbukan tidak lenting sama sekali. Hasil analisis data menunjukkan bahwa terdapat hubungan yang signifikan antara keterampilan matematika dengan kemampuan menyelesaikan soal fisika dengan besar koefisien korelasi 0,9041 termasuk dalam kategori tinggi. Hal ini menunjukkan bahwa apabila keterampilan matematika tinggi maka kemampuan menyelesaikan soalnya tinggi pula. Beberapa siswa yang memiliki keterampilan matematika tinggi tetapi kemampuan menyelesaikan soalnya rendah. Hal ini disebabkan siswa mengalami miskonsepsi berupa kesalahan fisis dan matematis, dengan besar kesalahan fisis dan matematis masing-masing sebesar 75% dan 65%. Kata kunci: Keterampilan Matematika, Miskonsepsi, Impuls Momentum Abstract: The purpose of this research is to determine the relationship between mathematics skill with the ability to solve physics problems to students misconception about impuls and momentum. Method of the research is descriptive correlation. The sample are 25 students. The instrument used 5 essay about elastic collision and inelastic collision. The data showed that mathematics skill and ability to solve physics problem have a significant relationship with a correlation coefficient 0,9041 that included in the high category. It shows someone that have high mathematics skills, the ability to solve problem be high too. There are some students that have high mathematics skill but the ability to solve problem is low. This is because the student have misconception there are physical and mathematical errors with each of these errors by 75% and 65%. Keywords: Mathematics Skill, Misconception, Impuls Momentum
Function of the growth-regulated transcription initiation factor TIF-IA in initiation complex formation at the murine ribosomal gene promoter

Alterations in the rate of cell proliferation are accompanied by changes in the transcription of rRNA genes. In mammals, this growth-dependent regulation of transcription of genes coding for rRNA (rDNA) is due to reduction of the amount or activity of an essential transcription factor, called TIF-IA. Extracts prepared from quiescent cells lack this factor activity and, therefore, are transcriptionally inactive. We have purified TIF-IA from exponentially growing cells and have shown that it is a polypeptide with a molecular mass of 75 kDa which exists as a monomer in solution. Using a reconstituted transcription system consisting of purified transcription factors, we demonstrate that TIF-IA is a bona fide transcription initiation factor which interacts with RNA polymerase I. Preinitiation complexes can be assembled in the absence of TIF-IA, but formation of the first phosphodiester bonds of nascent rRNA is precluded. After initiation, TIF-IA is liberated from the initiation complex and facilitates transcription from templates bearing preinitiation complexes which lack TIF-IA. Despite the pronounced species specificity of class I gene transcription, this growth-dependent factor has been identified not only in mouse but also in human cells. Murine TIF-IA complements extracts from both growth-inhibited mouse and human cells. The analogous human activity appears to be similar or identical to that of TIF-IA. Therefore, despite the fact that the RNA polymerase transcription system has evolved sufficiently rapidly that an rDNA promoter from one species will not function in another species, the basic mechanisms that adapt ribosome synthesis to cell proliferation have been conserved.
Mineralocorticoid Receptors Guide Spatial and Stimulus-Response Learning in Mice

Adrenal corticosteroid hormones act via mineralocorticoid (MR) and glucocorticoid receptors (GR) in the brain, influencing learning and memory. MRs have been implicated in the initial behavioral response in novel situations, which includes behavioral strategies in learning tasks. Different strategies can be used to solve navigational tasks, for example hippocampus-dependent spatial or striatum-dependent stimulus-response strategies. Previous studies suggested that MRs are involved in spatial learning and induce a shift between learning strategies when animals are allowed a choice between both strategies. In the present study, we further explored the role of MRs in spatial and stimulus-response learning in two separate circular holeboard tasks using female mice with forebrain-specific MR deficiency and MR overexpression and their wildtype control littermates. In addition, we studied sex-specific effects using male and female MR-deficient mice. First, we found that MR-deficient compared to control littermates and MR-overexpressing mice display altered exploratory and searching behavior indicative of impaired acquisition of novel information. Second, female (but not male) MR-deficient mice were impaired in the spatial task, while MR-overexpressing female mice showed improved performance in the spatial task. Third, MR-deficient mice were also impaired in the stimulus-response task compared to controls and (in the case of females) MR-overexpressing mice. We conclude that MRs are important for coordinating the processing of information relevant for spatial as well as stimulus-response learning.
Peripheral blood monitoring of chronic myeloid leukemia during treatment with imatinib, second‐line agents, and beyond

The current study was conducted to compare simultaneously obtained bone marrow (BM) cytogenetics (CTG), peripheral blood (PB) and BM fluorescence in situ hybridization (FISH), and quantitative real‐time polymerase chain reaction (Q‐PCR) for BCR‐ABL1 in monitoring response to treatment with tyrosine kinase inhibitors and homoharringtonine (HHT) in patients with chronic myeloid leukemia (CML).
HOW TO TREAT HYPERTENSION IN BLACKS: REVIEW OF THE EVIDENCE

Abstract Presentation, response to therapy, and clinical outcome differ according to race for patients with hypertension. Black patients have a higher prevalence and earlier onset of hypertension than other ethnic groups, with poorer prognosis than white patients. Blacks are more likely to be salt-sensitive, and to have a low plasma renin activity than are whites. They are at much greater risk of developing cardiovascular and renal complications. Despite many advances in the understanding and treatment of cardiovascular diseases, black patients continue to have increased morbidity and mortality from the end-organ complications of hypertension. The explanations for these observations remain incompletely understood, but genetic differences, added to socio-economic and environmental factors, have been proposed to explain this disparity. The first therapeutic approach is to decrease salt and increase potassium intakes. Diuretics (thiazides and potassium-sparing agents) and calcium channel blockers constitute the first antihypertensive drug choices. The angiotensin-converting-enzyme inhibitors, the angiotensin II receptor blockers and beta-blockers appear to be less effective in blacks with regard to uncomplicated hypertension, especially in older people, but addition of a small dose of diuretic improves their efficacy. These combinations are preferred among patients with chronic kidney disease or heart failure. The goal for blood pressure target is the same in blacks as it is in whites, being a blood pressure of less than 140/90 mmHg in uncomplicated hypertension and less than 130/80 mmHg in patients with diabetes mellitus or chronic kidney disease.
Association between border cell responses and localized root infection by pathogenic Aphanomyces euteiches.

BACKGROUND AND AIMS The oomycete Aphanomyces euteiches causes up to 80 % crop loss in pea (Pisum sativum). Aphanomyces euteiches invades the root system leading to a complete arrest of root growth and ultimately to plant death. To date, disease control measures are limited to crop rotation and no resistant pea lines are available. The present study aims to get a deeper understanding of the early oomycete-plant interaction at the tissue and cellular levels. METHODS Here, the process of root infection by A. euteiches on pea is investigated using flow cytometry and microscopic techniques. Dynamic changes in secondary metabolism are analysed with high-performance liquid chromatography with diode-array detection. KEY RESULTS Root infection is initiated in the elongation zone but not in the root cap and border cells. Border-cell production is significantly enhanced in response to root inoculation with changes in their size and morphology. The stimulatory effect of A. euteiches on border-cell production is dependent on the number of oospores inoculated. Interestingly, border cells respond to pathogen challenge by increasing the synthesis of the phytoalexin pisatin. CONCLUSIONS Distinctive responses to A. euteiches inoculation occur at the root tissue level. The findings suggest that root border cells in pea are involved in local defence of the root tip against A. euteiches. Root border cells constitute a convenient quantitative model to measure the molecular and cellular basis of plant-microbe interactions.
Infliximab prevents Crohn's disease recurrence after ileal resection.

BACKGROUND & AIMS Crohn's disease commonly recurs after intestinal resection. We evaluated whether the administration of infliximab after resective intestinal surgery for Crohn's disease reduces postoperative recurrence. METHODS We randomly assigned 24 patients with Crohn's disease who had undergone ileocolonic resection to receive intravenous infliximab (5 mg/kg), administered within 4 weeks of surgery and continued for 1 year, or placebo. The primary end point was the proportion of patients with endoscopic recurrence at 1 year. Secondary end points were clinical recurrence and remission and histologic recurrence. RESULTS The rate of endoscopic recurrence at 1 year was significantly lower in the infliximab group (1 of 11 patients; 9.1%) compared with the placebo group (11 of 13 patients; 84.6%) (P = .0006). There was a nonsignificant higher proportion of patients in clinical remission in the infliximab group (8 of 10; 80.0%) compared with the placebo group (7 of 13; 53.8%) (P = .38). The histologic recurrence rate at 1 year was significantly lower in the infliximab group (3 of 11 patients; 27.3%) compared with the placebo group (11 of 13 patients; 84.6%) (P = .01). The occurrence of adverse events was similar between the placebo and infliximab groups, and none occurred in the immediate postoperative period. CONCLUSIONS Administration of infliximab after intestinal resective surgery was effective at preventing endoscopic and histologic recurrence of Crohn's disease.
Toward an Integration of Training Theory and Technique

Reviewers of the training literature have generally concluded that training theory and practice are not well integrated, and that research findings are not often translated into useful training methods. In an effort to bridge the gap between training theory and practice, an organizing framework for conceptualizing training research is presented. The purpose of the framework is to highlight the linkages between training-related theory and technique in the areas of training analysis, design, and evaluation. The linkages are described in detail, and illustrated via consideration of research into mental models. We hope that the framework will lead to future research programs that enhance the transition of training research from theory into practice, and integrate more fully these two perspectives
Predicting Acculturative Orientations of American College Students toward International Students

Acculturation refers to the degree to which immigrants maintain their ethnic culture and accept or reject the new dominant culture. While considerable studies have focused on immigrants’ acculturative processes, little is known about acculturation from the perspective of the host culture. This study examined American students’ acculturation orientations toward international students based on the concept of interactive acculturation and investigated the influence of ethnocentrism, sex, and Facebook use on such acculturation attitudes. Results from a survey of 346 American college students indicated a high degree of individualism and integrationism over other orientations, namely transformation-integrationism, exclusionism, assimilationism, and segregationism. The model with ethnocentrism, sex, and Facebook usage predicted five of the six acculturation orientations, with ethnocentrism being the most important predictor.
The Effect of Apical and Basolateral Lipids on the Function of the Band 3 Anion Exchange Protein

Although many polarized proteins are sorted to the same membrane domain in all epithelial tissues, there are some that exhibit a cell type–specific polarity. We recently found that band 3 (the anion exchanger AE1) was present in the apical membrane of a renal intercalated cell line when these cells were seeded at low density, but its targeting was reversed to the basolateral membrane under the influence of an extracellular matrix protein secreted when the cells were seeded at high density. Because apical and basolateral lipids differ in epithelia, we asked what effect might these lipids have on band 3 function. This question is especially interesting since apical anion exchange in these cells is resistant to disulfonic stilbene inhibitors while basolateral anion exchange is quite sensitive. Furthermore, the apical anion exchanger cannot be stained by antibodies that readily identify the basolateral protein. We used short chain sphingolipid analogues and found that sphingomyelin was preferentially targeted to the basolateral domain in the intercalated cell line. The ganglioside GM1 (Gal 1β1, 3GalNAcβ1, 4Gal-NeuAcα2, 3Galβ1, 4Glc ceramide) was confined to the apical membrane as visualized by confocal microscopy after addition of fluorescent cholera toxin to filter grown cells. We reconstituted erythrocyte band 3 into liposomes using apical and basolateral types of lipids and examined the inhibitory potency of 4,4′-dinitorsostilbene-2,2′-disulfonic acid (DNDS; a reversible stilbene) on 35SO4/SO4 exchange. Although anion exchange in sphingomyelin liposomes was sensitive to inhibition, the addition of increasing amounts of the ganglioside GM1 reduced the potency of the inhibitor drastically. Because these polarized lipids are present in the exofacial surface of the bilayer, we propose that the lipid structure might influence the packing of the transmembrane domains of band 3 in that region, altering the binding of the stilbenes to these chains. These results highlight the role of polarized lipids in changing the function of unpolarized proteins or of proteins whose locations differ in different epithelia.
The Impact of Food‐Related Values on Food Purchase Behavior and the Mediating Role of Attitudes: A Swiss Study

Personal values and attitudes can help to explain food choice. This study confirmed a hierarchical organization of the value–attitude–behavior chain: Food-related values influence attitudes, and these, in turn, impact behavior. Contrary to previous findings, values are only partially mediated by attitudes: Some food-related values are fully mediated, whereas others are partially mediated, and still others have exclusively direct effects on purchase behavior. Questionnaire data from a roughly representative sample of 851 adults living in Switzerland was complemented with actual food purchase behavior measured by a loyalty card of a Swiss retailer over the period of one year. Four theoretically derived structural equation models were compared across eight different food product categories (organic, fair trade, low-budget, fresh convenience, ready-to-eat, light, functional foods, fruits and vegetables). The results question central assumptions of the theory of planned behavior and emphasize the role of food-related values in food consumption. Implications for marketing and future product developments of food companies are discussed.