Miracle-dz/UniFAR-FTUs huggingface dataset:
An economic typology of small-scale rural enterprises in Central Province, Kenya

An economic typology of rural non-farm enterprises is developed using a large sample of enterprises located in Central Province, Kenya. Multivariate methods reduce 19 economic variables to 5 principal components representing the size, capital inten- sity, profitability, growth of capital, and profit margin of an enterprise. Within the 5-dimensional space defined by these components, five main types of enterprise are identified as follows: successful intermediate enterprises; profitable small enterprises; unprofitable small enterprises; larger static enterprises; and small enterprises with high profit margins. The results testify to the economic and functional diversity of this sector, and place in doubt broad generalizations about its economic and developmental role. Some implications of the typology for planning policy are discussed. for developing the typology. The second section presents the methodology in some detail, including discussion of data sources, the economic variables used in the classification procedure, and the techniques used to produce the classification. The five components derived from the analysis are interpreted in the third section, while the typology based on the component scores is the subject of the following section. The results are discussed in the fifth and final section,
Optimization of Helical Antennas

Helical antennas have been known for more than half a century, but it seems that reliable design data for helical antennas do not exist in the open literature. This paper points out some inaccurate data about helical antennas, and presents a new set of data related to the optimum design of helical antennas. The antenna's performance is optimized by varying the antenna's geometrical parameters for narrowband and broadband designs. Based on these results, a set of diagrams is provided to enable simple but accurate design of helical antennas above an infinite ground plane. Finally, the results are experimentally verified.
Risk factors of obesity in a five year old population. Parental versus environmental factors.

To be more effective, the prevention of obesity in childhood should be focused on the population at risk. The purpose of the present study is firstly to find correlations between certain environmental factors and obesity in childhood, and secondly to measure the influence of the environmental factors after taking the parental history of obesity into account. This case controlled study includes 704 controls vs. 327 cases selected in a population of five year old school children. The anthropometric assessment was completed at school. Obesity was defined as a weight for height > or = 2 s.d. using the French weight charts for French children based on sex and height. Interviews of the parents recorded parental overweight and child birth overweight as 'constitutional' factors and family structure, socio-economic level and daily lifestyle (sleep, TV viewing, after school care, etc.) as 'environmental' factors. The results show that parental overweight and birth overweight are closely related to the child's obesity at five years of age (estimated relative risks 3.1 and 2.4 respectively). The environmental factors which contribute to child obesity are: southern European origin of the mother, snacks, excessive television viewing and, more importantly, short sleep duration (estimated relative risks = 1.9, 1.3, 2.1 and 4.9 respectively). A logistic regression model, after taking parental overweight into account, shows that the relationship between obesity and short sleep duration persists independently of television viewing. The hypotheses raised by these findings are discussed.
Distinct Modes of Regulation by Chromatin Encoded through Nucleosome Positioning Signals

The detailed positions of nucleosomes profoundly impact gene regulation and are partly encoded by the genomic DNA sequence. However, less is known about the functional consequences of this encoding. Here, we address this question using a genome-wide map of ∼380,000 yeast nucleosomes that we sequenced in their entirety. Utilizing the high resolution of our map, we refine our understanding of how nucleosome organizations are encoded by the DNA sequence and demonstrate that the genomic sequence is highly predictive of the in vivo nucleosome organization, even across new nucleosome-bound sequences that we isolated from fly and human. We find that Poly(dA:dT) tracts are an important component of these nucleosome positioning signals and that their nucleosome-disfavoring action results in large nucleosome depletion over them and over their flanking regions and enhances the accessibility of transcription factors to their cognate sites. Our results suggest that the yeast genome may utilize these nucleosome positioning signals to regulate gene expression with different transcriptional noise and activation kinetics and DNA replication with different origin efficiency. These distinct functions may be achieved by encoding both relatively closed (nucleosome-covered) chromatin organizations over some factor binding sites, where factors must compete with nucleosomes for DNA access, and relatively open (nucleosome-depleted) organizations over other factor sites, where factors bind without competition.
THE LOW-BACK MERGER IN THE STEEL CITY: AFRICAN AMERICAN ENGLISH IN PITTSBURGH

This article investigates the status of the low-back vowels in African American English in Pittsburgh, Pennsylvania, where the vowels have been merged since at least the late 1800s. The low-back merger is currently spreading across much of the United States, but to date, its incidence in African American speech has been found to be limited. This article draws from a sample of 34 African Americans native to Pittsburgh. Using data from a word list along with an acoustic analysis of the low-back vowels in conversational speech from sociolinguistic interviews, this article shows that African Americans in Pittsburgh have merged the low-back vowels, thus sharing in this feature of the local phonological system. The article also explores the sociohistorical conditions that facilitated the spread of the merger from white to African American speech in the region.
Type 2 Diabetes Risk Alleles Are Associated With Reduced Size at Birth

OBJECTIVE Low birth weight is associated with an increased risk of type 2 diabetes. The mechanisms underlying this association are unknown and may represent intrauterine programming or two phenotypes of one genotype. The fetal insulin hypothesis proposes that common genetic variants that reduce insulin secretion or action may predispose to type 2 diabetes and also reduce birth weight, since insulin is a key fetal growth factor. We tested whether common genetic variants that predispose to type 2 diabetes also reduce birth weight. RESEARCH DESIGN AND METHODS We genotyped single-nucleotide polymorphisms (SNPs) at five recently identified type 2 diabetes loci (CDKAL1, CDKN2A/B, HHEX-IDE, IGF2BP2, and SLC30A8) in 7,986 mothers and 19,200 offspring from four studies of white Europeans. We tested the association between maternal or fetal genotype at each locus and birth weight of the offspring. RESULTS We found that type 2 diabetes risk alleles at the CDKAL1 and HHEX-IDE loci were associated with reduced birth weight when inherited by the fetus (21 g [95% CI 11–31], P = 2 × 10−5, and 14 g [4–23], P = 0.004, lower birth weight per risk allele, respectively). The 4% of offspring carrying four risk alleles at these two loci were 80 g (95% CI 39–120) lighter at birth than the 8% carrying none (Ptrend = 5 × 10−7). There were no associations between birth weight and fetal genotypes at the three other loci or maternal genotypes at any locus. CONCLUSIONS Our results are in keeping with the fetal insulin hypothesis and provide robust evidence that common disease-associated variants can alter size at birth directly through the fetal genotype.
Managing organizational change: paradoxical problems, solutions, and consequences

Purpose – The purpose of this paper is to examine how paradox emerges during a planned change initiative to improve and dramatically transform inter‐agency information sharing. Based on interviews with key decision makers, the authors interrogate the relationships among institutional contradictions, emergent dualities, the communicative management of related organizational stakeholder paradoxes, and the consequences of enacted solutions.Design/methodology/approach – Interviews with government leaders serve as the data source. These decision makers are from justice agencies participating in planning an information‐sharing program to better protect citizens and their agencies' workforce.Findings – The data suggests that Seo and Creed's institutional contradiction “isomorphism conflicting with divergent interests” gave rise to three interdependent dualities: stakeholder self‐interest/collective good, stakeholder inclusion/exclusion, and emergent stakeholder consensus/leader driven decision making. These dual.
Assessing Mediation in Dyadic Data Using the Actor-Partner Interdependence Model

The assessment of mediation in dyadic data is an important issue if researchers are to test process models. Using an extended version of the actor–partner interdependence model the estimation and testing of mediation is complex, especially when dyad members are distinguishable (e.g., heterosexual couples). We show how the complexity of the model can be reduced by assuming specific dyadic patterns. Using structural equation modeling, we demonstrate how specific mediating effects and contrasts among effects can be tested by phantom models that permit point and bootstrap interval estimates. We illustrate the assessment of mediation and the strategies to simplify the model using data from heterosexual couples.
Raman spectroscopy as a tool to investigate the structure and electronic properties of carbon-atom wires

Graphene, nanotubes and other carbon nanostructures have shown potential as candidates for advanced technological applications due to the different coordination of carbon atoms and to the possibility of π-conjugation. In this context, atomic-scale wires comprised of sp-hybridized carbon atoms represent ideal 1D systems to potentially downscale devices to the atomic level. Carbon-atom wires (CAWs) can be arranged in two possible structures: a sequence of double bonds (cumulenes), resulting in a 1D metal, or an alternating sequence of single–triple bonds (polyynes), expected to show semiconducting properties. The electronic and optical properties of CAWs can be finely tuned by controlling the wire length (i.e., the number of carbon atoms) and the type of termination (e.g., atom, molecular group or nanostructure). Although linear, sp-hybridized carbon systems are still considered elusive and unstable materials, a number of nanostructures consisting of sp-carbon wires have been produced and characterized to date. In this short review, we present the main CAW synthesis techniques and stabilization strategies and we discuss the current status of the understanding of their structural, electronic and vibrational properties with particular attention to how these properties are related to one another. We focus on the use of vibrational spectroscopy to provide information on the structural and electronic properties of the system (e.g., determination of wire length). Moreover, by employing Raman spectroscopy and surface enhanced Raman scattering in combination with the support of first principles calculations, we show that a detailed understanding of the charge transfer between CAWs and metal nanoparticles may open the possibility to tune the electronic structure from alternating to equalized bonds.
This Work Is Licensed under a Creative Commons Attribution 4.0 International License Embargo Release Date: Resting State in Parkinson's Disease Dementia and Dementia with Lewy Bodies: Commonalities and Differences

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. Objective: Dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD) are two demen-tias with overlapping phenotypes. Clinically, these are differentiated by the one-year precedence rule between the onset of dementia with respect to Parkinsonism. In this report we aimed to find differences between DLB and PDD in functional connectivity (FC) using resting state functional magnetic resonance imaging, which we hypothesised would reflect the underlying pathological differences between DLB and PDD. Methods: The study cohort comprised of 18 patients with DLB, 12 with PDD and 17 healthy control (HC) groups. Eight cortical and four subcortical seeds were chosen, and time series extracted to estimate correlation maps. We also implemented a voxel-based morphometry (VBM) analysis to assess regional grey matter differences. FC analysis was corrected for age, sex and regional grey matter differences. Results: The FC analysis showed greater alterations in DLB than in PDD for seeds placed within the fronto-parietal network (FPN), whilst in contrast, for the supplementary motor area seed FC alterations were more apparent in PDD than in DLB. However, when comparing DLB and PDD, no significant differences were found. In addition, VBM analysis revealed greater atrophy in PDD than HC and DLB in the bilateral motor cortices and precuneus respectively. Conclusions: PDD and DLB demonstrate similar FC alterations in the brain. However, attention-and motor-related seeds revealed subtle differences between both conditions when compared with HC, which may relate to the neuropathology and chronological precedence of core symptoms in the Lewy body dementias.
Assessment of Chemistry Laboratory Classroom Environments

Abstract The Science Laboratory Environment Inventory (SLEI) is a recently developed classroom environment instrument for assessing students' or teachers' perceptions of their science laboratory classroom environment. This paper describes its development and reports on the validation and application of its modified form, the Chemistry Laboratory Environment Inventory (CLEI), with a Singapore secondary school sample. The sample consisted of 1 592 final-year secondary school (i.e. tenth grade) chemistry students from 56 intact classes from 28 randomly selected co-educational government secondary schools in Singapore. Various item and factor analyses supported the reliability and validity of the instrument for assessing students' perceptions of their chemistry laboratory environment specifically in Singapore.
Release of immune modulation factors from platelet concentrates during storage after photochemical pathogen inactivation treatment

BACKGROUND: Blood platelets (PLTs) are critical for hemostasis, and they contain biologically active constituents with the potential to modulate inflammatory responses. This study examined the effects of photochemical pathogen inactivation treatment (PCT) on the release of cytokines and/or chemokines from PLT components.
Renal interstitial adenosine metabolism during ischemia in dogs.

The present study was conducted to determine the metabolism of renal interstitial adenosine under resting conditions and during ischemia. By using a microdialysis method with HPLC-fluorometric analysis, renal interstitial concentrations of adenosine, inosine, and hypoxanthine were assessed in pentobarbital-anesthetized dogs. Average basal renal interstitial concentrations of adenosine, inosine, and hypoxanthine were 0.18 +/- 0.04, 0.31 +/- 0.05, and 0.35 +/- 0.05 micromol/l, respectively. Local inhibition of adenosine kinase with iodotubercidin (10 micromol/l in perfusate) or inhibition of adenosine deaminase with erythro-9-(2-hydroxy-3-nonyl)adenine (EHNA; 100 micromol/l in perfusate) did not change adenosine concentrations in the nonischemic kidneys (0.18 +/- 0.04 and 0.24 +/- 0.05 micromol/l, respectively). On the other hand, treatment with iodotubercidin+EHNA significantly increased adenosine concentration (0.52 +/- 0.07 micromol/l) with significant decreases in inosine and hypoxanthine levels (0.13 +/- 0.03 and 0.19 +/- 0.04 micromol/l, respectively). During 30 min of ischemia, adenosine, inosine, and hypoxanthine were significantly increased to 0.76 +/- 0.29, 2.14 +/- 0.45, and 21.8 +/- 4.7 micromol/l, respectively. The treatment with iodotubercidin did not alter ischemia-induced increase in adenosine (0.84 +/- 0.18 micromol/l); however, EHNA alone markedly enhanced adenosine accumulation (13.54 +/- 2.16 micromol/l), the value of which was not augmented by an addition of iodotubercidin (15.80 +/- 1.24 micromol/l). In contrast, ischemia-induced increases in inosine and hypoxanthine were inversely diminished by the treatment with iodotubercidin+EHNA (0.90 +/- 0.20 and 9.86 +/- 1.96 micromol/l, respectively). These results suggest that both adenosine kinase and adenosine deaminase contribute to the metabolism of renal interstitial adenosine under resting conditions, whereas adenosine produced during ischemia is mainly metabolized by adenosine deaminase and the rephosphorylation of adenosine by adenosine kinase is small.sent
Visibility and Natural Quiet in National Parks and Wilderness Areas

For over a century, authorities have recognized cultural and psychological benefits of preserving national parks and wilderness areas. Yet, with increasesin visitation and mechanized travel, air and noise pollution are intruding moreand more into preserved natural areas. Psychological research shows that humans can detect very lowlevels of these pollutants in natural and laboratory settings, that air and noise pollution detract from the enjoyment of the visitor experience, and that people place a high value on naturally quiet, pollution-free settings. This article discusses how psychological research is essential for a more complete understanding of the value and the influence of both visibility and quiet surroundings with a focus on applied, field-based research in national parks and wilderness areas. The article concludes with recommendations for future directions in research in these areas and argues that implications of psychological research results should be addressed in the natural resource policy-making process.
Outcomes of initial noninvasive Helicobacter pylori testing in U.S. primary care patients with uninvestigated dyspepsia

OBJECTIVE:Recent European trials demonstrate that testing and treatment for Helicobacter pylori (H. pylori) is an effective alternative to prompt endoscopy in uninvestigated dyspepsia. The eventual endoscopy rate after H. pylori testing, which is a key determinant of cost-effectiveness, is unknown in the United States. Our aim was to determine the endoscopy rate after H. pylori testing in primary care practice in the United States and to compare outcomes among seropositive and seronegative patients.METHODS:We performed a retrospective review with mean 13 month follow-up of primary care patients with dyspeptic symptoms tested with office-based H. pylori serology.RESULTS:Of 268 adults tested (37 ± 11 yr, 58% women), 57 (21%) were seropositive and 49/57 (86%) received eradication therapy. Endoscopy or contrast radiography was performed on 19% of seropositive and 19% of seronegative patients (p = 0.97). Annualized median disease-related expenditures were similar among seropositive and seronegative patients ($228 [$93–$654] vs $ 366 [$107–$1268], p = 0.19). However, aggregate expenditures were substantially lower than the cost of endoscopy alone ($816 [$296–$970]). On follow-up, seropositive and seronegative patients had similar numbers of primary care visits (2.9 ± 3.2 vs 3.5 ± 3.6, p = 0.23), prolonged antisecretory medication use (25 vs 33%, p = 0.27), and specialist referrals (23 vs 24%, p = 0.83). CONCLUSION:In a United States center, 81% of primary care patients tested for H. pylori did not undergo endoscopy, and patients incurred significantly lower median expenditures after noninvasive H. pylori testing than the cost of endoscopy alone. Seropositive and seronegative patients experienced comparable outcomes after H. pylori testing.
Empirically based assessment and taxonomy : applications to clinical research

The empirically based paradigm uses standardized procedures to assess problems reported by different informants. Multivariate analyses are used to derive taxonomic constructs comprising syndromes that are robust across samples and assessment procedures. The taxonomic constructs are operationally defined via scales that are normed in relation to participants' characteristics and the sources of data. New cases can be evaluated via the same assessment procedures that are used to derive and operationalize the constructs. Spanning from age 2 to 27, applications of the paradigm were illustrated with cross-cultural, longitudinal, accelerated longitudinal, treatment, and diagnostic studies. The empirically based approach provides productive alternatives to the agendas for research and services implied by the Diagnostic and Statistical Manual of Mental Disorders, especially in managed care contexts.
Model Predictive Control for Underwater Robots in Ocean Waves

Underwater robots beneath ocean waves can benefit from feedforward control to reduce position error. This letter proposes a method using model predictive control (MPC) to predict and counteract future disturbances from an ocean wave field. The MPC state estimator employs a linear wave theory (LWT) solver to approximate the component fluid dynamics under a wave field. Wave data from deployed ocean buoys are used to construct the simulated wave field. The MPC state estimator is used to optimize a set of control actions by gradient descent along a prediction horizon. The optimized control input minimizes a global cost function, the squared distance from the target state. The robot then carries out the optimized trajectory with an emphasis on real-time execution. Several prediction horizons are compared, with a horizon of 0.8 s selected as having a good balance of low error and fast computation. The controller with the chosen prediction horizon is simulated and found to show a 74% reduction in position error over traditional feedback control. Additional simulations are run where the MPC takes in noisy measurements of the wave field parameters. The MPC algorithm is shown to be resistant to sensor noise, showing a mean position error 44% lower than the noise-free feedback control case.
A Tale of Two Copenhagens: Carbon Markets and Climate Governance

Assessments of the UN Climate Change Conference in Copenhagen in December 2009 have tended to see it as a ‘return to realism’ — as the triumph of hard interstate bargaining over institutional or normative development about climate change. This article contests that interpretation by showing how it focuses too closely on the interstate negotiations and neglects the ongoing development of carbon markets as governance practices and systems to deal with climate change. It shows that there remains a strong normative consensus about such markets, and a deepening set of transnational governance practices. These governance practices only partly depend on the interstate negotiations. Thinking about the future of global climate governance needs to start with the complexity of interactions between these transnational governance systems and the interstate negotiations.