Miracle-dz/UniFAR-FTUs huggingface dataset:
Abrupt climate change: can society cope?

Consideration of abrupt climate change has generally been incorporated neither in analyses of climate–change impacts nor in the design of climate adaptation strategies. Yet the possibility of abrupt climate change triggered by human perturbation of the climate system is used to support the position of both those who urge stronger and earlier mitigative action than is currently being contemplated and those who argue that the unknowns in the Earth system are too large to justify such early action. This paper explores the question of abrupt climate change in terms of its potential implications for society, focusing on the UK and northwest Europe in particular. The nature of abrupt climate change and the different ways in which it has been defined and perceived are examined. Using the example of the collapse of the thermohaline circulation (THC), the suggested implications for society of abrupt climate change are reviewed; previous work has been largely speculative and has generally considered the implications only from economic and ecological perspectives. Some observations about the implications from a more social and behavioural science perspective are made. If abrupt climate change simply implies changes in the occurrence or intensity of extreme weather events, or an accelerated unidirectional change in climate, the design of adaptation to climate change can proceed within the existing paradigm, with appropriate adjustments. Limits to adaptation in some sectors or regions may be reached, and the costs of appropriate adaptive behaviour may be large, but strategy can develop on the basis of a predicted long–term unidirectional change in climate. It would be more challenging, however, if abrupt climate change implied a directional change in climate, as, for example, may well occur in northwest Europe following a collapse of the THC. There are two fundamental problems for society associated with such an outcome: first, the future changes in climate currently being anticipated and prepared for may reverse and, second, the probability of such a scenario occurring remains fundamentally unknown. The implications of both problems for climate policy and for decision making have not been researched. It is premature to argue therefore that abrupt climate change – in the sense referred to here – imposes unacceptable costs on society or the world economy, represents a catastrophic impact of climate change or constitutes a dangerous change in climate that should be avoided at all reasonable cost. We conclude by examining the implications of this contention for future research and policy formation.
SOS involvement in stress-inducible biofilm formation

Bacterial biofilm formation can be induced by antimicrobial and DNA damage agents. These agents trigger the SOS response, in which SOS sensor RecA stimulates auto-cleavage of repressor LexA. These observations lead to a hypothesis of a connection between stress-inducible biofilm formation and the RecA-LexA interplay. To test this hypothesis, three biofilm assays were conducted, viz. the standard 96-well assay, confocal laser scanning microscopy, and the newly developed biofilm-on-paper assay. It was found that biofilm stimulation by the DNA replication inhibitor hydroxyurea was dependent on RecA and appeared repressed by the non-cleavable LexA of Pseudomonas aeruginosa. Surprisingly, deletion of lexA led to reduction of both normal and stress-inducible biofilm formation, suggesting that the wild-type LexA contributes to biofilm formation. The decreases was not the result of poor growth of the mutants. These results suggest SOS involvement in hydroxyurea-inducible biofilm formation. In addition, with the paper biofilm assay, it was found that degradation of the biofilm matrix DNA by DNase I appeared to render the biofilms susceptible to the replication inhibitor. The puzzling questions concerning the roles of LexA in DNA release in the biofilm context are discussed.
Low Level Her2 Overexpression Is Associated with Rapid Tumor Cell Proliferation and Poor Prognosis in Prostate Cancer

Purpose: The HER2 oncogene is involved in the biology of many different tumor types and serves as a prognostic marker and a therapeutic target in breast cancer. In contrast to breast cancer, studies on Her2 overexpression and gene amplification in prostate cancer have yielded different results. The purpose of this study was to learn more on the prevalence and clinical significance of HER2 amplification and overexpression in prostate cancer. Experimental Design: A tissue microarray containing >2,000 prostate cancers with follow-up data was used. Tissue microarray sections were analyzed on protein and DNA level using two different antibodies (HercepTest, DAKO; Novocastra NCL-CB11) and fluorescence in situ hybridization. Results: Immunohistochemical analyses showed highly similar results for both antibodies. Detectable Her2 immunostaining was observed in 17.2% for the HercepTest and in 22.5% for the Novocastra antibody with the vast majority of cases showing 1+ or 2+ staining. For both antibodies (HercepTest/Novocastra), significant associations were found between positive staining and high Gleason grade (P < 0.0001, both), advanced pT stage (P < 0.0001/P = 0.0015), rapid tumor cell proliferation (P = 0.0004/P = 0.0071), and tumor recurrence (P < 0.0001, both). HER2 amplification was only found in 1 of 2,525 analyzable cases (0.04%). Conclusions: Low-level Her2 overexpression occurs at relevant frequency in prostate cancer and in the absence of gene amplification. Increased Her2 expression may potentially lead to an aggressive behavior of tumor cells through the stimulation of tumor cell proliferation because Her2 staining was shown to be significantly associated with Ki67 labeling index. These data argue for reconsidering anti-Her2 therapy, possibly with modified approaches. Clin Cancer Res; 16(5); 1553–60
PROTECTING LOCATION PRIVACY IN SENSOR NETWORKS AGAINST A GLOBAL EAVESDROPPER by KIRAN MEHTA

PROTECTING LOCATION PRIVACY IN SENSOR NETWORKS AGAINST A GLOBAL EAVESDROPPER KIRAN MEHTA, M.S. The University of Texas at Arlington, 2008 Supervising Professor: Donggang Liu While many protocols for sensor network security provide confidentiality for the content of messages, contextual information usually remains exposed. Such contextual information can be exploited by an adversary to derive sensitive information such as the locations of monitored objects and data sinks in the field. Attacks on these components can significantly undermine network applications. The existing techniques defend the leakage of location information only from an adversary who sees only local network traffic. However, a stronger adversary, the global eavesdropper, is realistic and can defeat all existing techniques. This paper first formalizes the location privacy issues in sensor networks under this strong adversary model and computes a lower bound on the communication overhead needed for achieving a certain level of location privacy. The paper then proposes two techniques to provide location privacy for monitored objects (source location privacy): periodic collection and source simulation, and two techniques to provide location privacy for data sinks (destination location privacy): destination simulation and backbone flooding. These techniques provide trade-offs between privacy, communication cost, and latency. The
E-Cigarette Surveillance With Social Media Data: Social Bots, Emerging Topics, and Trends

Background As e-cigarette use rapidly increases in popularity, data from online social systems (Twitter, Instagram, Google Web Search) can be used to capture and describe the social and environmental context in which individuals use, perceive, and are marketed this tobacco product. Social media data may serve as a massive focus group where people organically discuss e-cigarettes unprimed by a researcher, without instrument bias, captured in near real time and at low costs. Objective This study documents e-cigarette–related discussions on Twitter, describing themes of conversations and locations where Twitter users often discuss e-cigarettes, to identify priority areas for e-cigarette education campaigns. Additionally, this study demonstrates the importance of distinguishing between social bots and human users when attempting to understand public health–related behaviors and attitudes. Methods E-cigarette–related posts on Twitter (N=6,185,153) were collected from December 24, 2016, to April 21, 2017. Techniques drawn from network science were used to determine discussions of e-cigarettes by describing which hashtags co-occur (concept clusters) in a Twitter network. Posts and metadata were used to describe where geographically e-cigarette–related discussions in the United States occurred. Machine learning models were used to distinguish between Twitter posts reflecting attitudes and behaviors of genuine human users from those of social bots. Odds ratios were computed from 2x2 contingency tables to detect if hashtags varied by source (social bot vs human user) using the Fisher exact test to determine statistical significance. Results Clusters found in the corpus of hashtags from human users included behaviors (eg, #vaping), vaping identity (eg, #vapelife), and vaping community (eg, #vapenation). Additional clusters included products (eg, #eliquids), dual tobacco use (eg, #hookah), and polysubstance use (eg, #marijuana). Clusters found in the corpus of hashtags from social bots included health (eg, #health), smoking cessation (eg, #quitsmoking), and new products (eg, #ismog). Social bots were significantly more likely to post hashtags that referenced smoking cessation and new products compared to human users. The volume of tweets was highest in the Mid-Atlantic (eg, Pennsylvania, New Jersey, Maryland, and New York), followed by the West Coast and Southwest (eg, California, Arizona and Nevada). Conclusions Social media data may be used to complement and extend the surveillance of health behaviors including tobacco product use. Public health researchers could harness these data and methods to identify new products or devices. Furthermore, findings from this study demonstrate the importance of distinguishing between Twitter posts from social bots and humans when attempting to understand attitudes and behaviors. Social bots may be used to perpetuate the idea that e-cigarettes are helpful in cessation and to promote new products as they enter the marketplace.
Meta-Insight : Do People Really Know How Others See Them ?

Although people can accurately guess how others see them, many studies have suggested that this may only be because people generally assume that others see them as they see themselves. These findings raise the question: In their everyday lives, do people understand the distinction between how they see their own personality and how others see their personality? We examined whether people make this distinction, or whether people possess what we call meta-insight. In 3 studies, we assessed meta-insight for a broad range of traits (e.g., Big Five, intelligent, funny) across several naturalistic social contexts (e.g., first impression, friends). Our findings suggest that people can make valid distinctions between how they see themselves and how others see them. Thus, people seem to have some genuine insight into their reputation and do not achieve meta-accuracy only by capitalizing on the fact that others see them similarly to how they see themselves.
Eocene paleobotanical altimetry of Victoria's Eastern Uplands

ABSTRACT On the high-elevation, low-relief Bogong Plateau, within the Eastern Uplands in Victoria, well-preserved diverse macrofloras and microfloras have been recovered from Eocene sediments at two sites underlying Eocene–Oligocene basalts. Estimates of mean annual temperature (MAT) were made from the floras at each site, using a novel method calculating probability density functions and maximum likelihood co-occurrence climate envelopes of the nearest living relatives of multiple fossil taxa, and the proportion of non-toothed rather than toothed leaf margins of all fossil leaves. The most likely scenario is an Eocene MAT at Bogong Plateau of 18°C, consistent with the cloudy mesothermal montane environment indicated by the abundance of tree ferns and other flora. From the MAT, the maximum Eocene paleo-elevation of the flora sites on the plateau can be calculated using the ‘lapse rate’ method, and was probably around 550−700 m above sea-level (∼1000 m lower than at present), but with large uncertainties for these estimates. The macrofloras accumulated in stream valleys, so the maximum elevation of the Eastern Uplands at the time was greater, matching other estimates of >800 m. Uplift to the present elevation probably occurred ca 8–4 Ma, so the alpine environment on the high plains dates to this time, and the high-altitude biota has therefore developed in the last 8 million years.
Postoperative Sore Throat After Laryngoscopy With Macintosh or Glide Scope Video Laryngoscope Blade in Normal Airway Patients

Background: The Glide Scope videolaryngoscope provides a suitable view for intubation, with less force required. Objectives: The present study was conducted, to compare postoperative sore throat and hoarseness after laryngoscopy and intubation, by Macintosh blade or Glide Scope video laryngoscope in normal airway patients. Patients and Methods: Three hundred patients were randomly allocated into two groups of 150: Macintosh blade laryngoscope or Glide Scope video laryngoscope. The patients were evaluated for 48 hours for sore throat and hoarseness by an interview. Results: The incidence and severity of sore throat in the Glide Scope group, at 6, 24 and 48 hours after the operation, were significantly lower than in the Macintosh laryngoscope group. In addition, the incidence of hoarseness in the Glide Scope group, at 6 and 24 hours after the operation, were significantly lower than in the Macintosh laryngoscope group. The incidence and severity of sore throat in men, at 6 and 24 hours after the operation, were significantly lower than in the women. Conclusions: The incidence and severity of sore throat and hoarseness after tracheal intubation by Glide Scope were lower than in the Macintosh laryngoscope. The incidence and severity of sore throat were increased by intubation and longer operation times.
Added sugars and periodontal disease in young adults: an analysis of NHANES III data.

BACKGROUND Added sugar consumption seems to trigger a hyperinflammatory state and may result in visceral adiposity, dyslipidemia, and insulin resistance. These conditions are risk factors for periodontal disease. However, the role of sugar intake in the cause of periodontal disease has not been adequately studied. OBJECTIVE We evaluated the association between the frequency of added sugar consumption and periodontal disease in young adults by using NHANES III data. DESIGN Data from 2437 young adults (aged 18-25 y) who participated in NHANES III (1988-1994) were analyzed. We estimated the frequency of added sugar consumption by using food-frequency questionnaire responses. We considered periodontal disease to be present in teeth with bleeding on probing and a probing depth ≥3 mm at one or more sites. We evaluated this outcome as a discrete variable in Poisson regression models and as a categorical variable in multinomial logistic regression models adjusted for sex, age, race-ethnicity, education, poverty-income ratio, tobacco exposure, previous diagnosis of diabetes, and body mass index. RESULTS A high consumption of added sugars was associated with a greater prevalence of periodontal disease in middle [prevalence ratio (PR): 1.39; 95% CI: 1.02, 1.89] and upper (PR: 1.42; 95% CI: 1.08, 1.85) tertiles of consumption in the adjusted Poisson regression model. The upper tertile of added sugar intake was associated with periodontal disease in ≥2 teeth (PR: 1.73; 95% CI: 1.19, 2.52) but not with periodontal disease in only one tooth (PR: 0.85; 95% CI: 0.54, 1.34) in the adjusted multinomial logistic regression model. CONCLUSION A high frequency of consumption of added sugars is associated with periodontal disease, independent of traditional risk factors, suggesting that this consumption pattern may contribute to the systemic inflammation observed in periodontal disease and associated noncommunicable diseases.
Detection of extrapulmonary lesions with integrated PET/CT in the staging of lung cancer

The aim of the present study was to assess retrospectively the additional value of positron emission tomography (PET)/computed tomography (CT) in the detection of unexpected extrapulmonary lesions in the staging of patients with a malignant pulmonary lesion in comparison with CT and PET used alone. A total of 217 patients with a pathologically proven lung tumour underwent PET/CT. CT, PET and PET/CT were evaluated in the detection of extrapulmonary lesions. These abnormalities were compared with the final diagnosis obtained from the medical records and statistical analysis was carried out. In total, 108 lesions were clinically detected. PET/CT showed a sensitivity, specificity, positive and negative predictive values and accuracy of 100, 81, 71, 100 and 87%, respectively, for the detection of extrapulmonary lesions and 92, 98, 89, 98 and 97%, respectively, for the detection of malignant extrapulmonary lesions. PET/CT was significantly better than CT and PET used alone. Conventional staging work-up has a poor sensitivity in detecting second primary cancers or unexpected metastases. The detection of malignant extrapulmonary lesions is necessary for correct tumour staging. By combining both metabolic and anatomical information, positron emission tomography/computed tomography is able to depict more unexpected extrapulmonary lesions than computed tomography and positron emission tomography used alone, and positron emission tomography/computed tomography provides more additional information of malignancy or benignancy of lesions detected with one of the two imaging modalities alone.
Water spin dynamics during apoptotic cell death in glioma gene therapy probed by T1ρ and T2ρ

Longitudinal and transverse relaxations in the rotating frame, with characteristic time constants T1ρ and T2ρ, respectively, have potential to provide unique MRI contrast in vivo. On‐resonance spin‐lock T1ρ with different spin‐lock field strengths and adiabatic T2ρ with different radiofrequency‐modulation functions were measured in BT4C gliomas treated with Herpes Simplex Virus thymidine kinase (HVS‐tk) gene therapy causing apoptotic cell death. These NMR tools were able to discriminate different treatment responses in tumor tissue from day 4 onward. An equilibrium two‐site exchange model was used to calculate intrinsic parameters describing changes in water dynamics. Observed changes included increased correlation time of water associated with macromolecules and a decreased fractional population of this pool. These results are consistent with destructive intracellular processes associated with cell death and the increase of extracellular space during the treatment. Furthermore, association between longer exchange correlation time and decreased pH during apoptosis is discussed. In this study, we demonstrated that T1ρ and T2ρ MR imaging are useful tools to quantify early changes in water dynamics reflecting treatment response during gene therapy. Magn Reson Med 59:1311–1319, 2008. © 2008 Wiley‐Liss, Inc.
Interobserver Variation of ASPECTS in Real Time

Background— The Alberta Stroke Program Early CT Score (ASPECTS) has been used to quantify early ischemic changes on computed tomography (CT) brain scans of acute stroke patients. We sought to assess the reliability of the score when performed in real time as compared with an expert rating performed at a later time point. Methods— Two hundred fourteen patients presenting with acute ischemic stroke or transient ischemic attack were prospectively recruited if they had a brain CT scan performed within 12 hours of symptom onset. Each scan was read for ASPECTS prospectively by the treating physician and later by 1 expert reader. A weighted kappa statistic was used to determine the interobserver agreement. Results— The median baseline National Institutes of Health Stroke Scale score was 5 (range: 0 to 32) and the median time to CT scan was 152 minutes (range: 22 to 769). The interobserver agreement between ASPECTS performed in real time and expert ASPECTS was substantial (κw=0.69). The mean difference between real-time ASPECTS and expert ASPECTS was 0 (SD: 1.1). Conclusions— ASPECTS is a reliable clinical scale for rating early ischemic changes on CT when performed in real time.
Inhibitory effect of blue light emitting diode on migration and invasion of cancer cells

The aim of this study was to determine the effects and molecular mechanism of blue light emitting diode (LED) in tumor cells. A migration and invasion assay for the metastatic behavior of mouse colon cancer CT‐26 and human fibrosarcoma HT‐1080 cells was performed. Cancer cell migration‐related proteins were identified by obtaining a 2‐dimensional gel electrophoresis (2‐DE) in total cellular protein profile of blue LED‐irradiated cancer cells, followed by matrix‐assisted laser desorption/ionization‐time of flight (MALDI‐TOF) analysis of proteins. Protein levels were examined by immunoblotting. Irradiation with blue LED inhibited CT‐26 and HT‐1080 cell migration and invasion. The anti‐metastatic effects of blue LED irradiation were associated with inhibition of matrix metalloproteinase (MMP)‐2 and MMP‐9 expression. P38 MAPK phosphorylation was increased in blue LED‐irradiated CT‐26 and HT‐1080 cells, but was inhibited after pretreatment with SB203580, a specific inhibitor of p38 MAPK. Inhibition of p38 MAPK phosphorylation by SB203580 treatment increased number of migratory cancer cells in CT‐26 and HT‐1080 cells, indicating that blue LED irradiation inhibited cancer cell migration via phosphorylation of p38 MAPK. Additionally blue LED irradiation of mice injected with CT‐26 cells expressing luciferase decreased early stage lung metastasis compared to untreated control mice. These results indicate that blue LED irradiation inhibits cancer cell migration and invasion in vitro and in vivo.
Bmc Infectious Diseases the Impact and Effectiveness of Pneumococcal Vaccination in Scotland for Those Aged 65 and over during Winter 2003/2004

Background: For winter 2003/2004 in Scotland, it was recommended that all those aged 65 and over be eligible to receive 23-valent polysaccharide pneumococcal vaccine (23vPPV), which has been shown to be effective in reducing the risk of invasive pneumococcal disease (IPD). We assessed the success of the vaccination programme by examining the age specific incidence rates of IPD compared to four previous winter seasons and estimating vaccination effectiveness.
Community-Based Reasoning in Games: Salience, Rule-Following, and Counterfactuals

This paper develops a game-theoretic and epistemic account of a peculiar mode of practical reasoning that sustains focal points but also more general forms of rule-following behavior which I call community-based reasoning (CBR). It emphasizes the importance of counterfactuals in strategic interactions. In particular, the existence of rules does not reduce to observable behavioral patterns but also encompasses a range of counterfactual beliefs and behaviors. This feature was already at the core of Wittgenstein’s philosophical account of rule-following. On this basis, I consider the possibility that CBR may provide a rational basis for cooperation in the prisoner’s dilemma.