Miracle-dz/UniFAR-FTUs huggingface dataset:
Subpleural block is less effective than thoracic epidural analgesia for post-thoracotomy pain: a randomised controlled study

Context Thoracic epidural and paravertebral blocks provide adequate analgesia for postoperative thoracotomy pain. Both procedures are usually performed percutaneously with considerable failure rates. A subpleural catheter placed in the space posterior to the parietal pleura and alongside the paravertebral area may provide superior postoperative pain relief. Objective To compare subpleural analgesia with thoracic epidural analgesia in patients undergoing thoracotomy. Design Randomised, double-blind study. Setting A tertiary care University Medical Centre between 26 June 2008 and 21 March 2011. Patients Forty-two patients scheduled for elective posterolateral thoracotomy. Patients with American Society of Anesthesiologists physical status ≥4, with a previous history of thoracotomy, on chronic pain medications or with a contraindication to receiving local anaesthetics or thoracic epidural block were excluded from the study. Interventions Patients were randomised to receive either subpleural analgesia or thoracic epidural analgesia for 24-h post-thoracotomy pain control. Main outcome measures A visual analogue scale was used to assess pain at rest and on coughing during the first 24 h postoperatively and the incidence of hypotension was recorded. Results Patients who received subpleural analgesia had higher visual analogue scores at rest and on coughing than those who received thoracic epidural analgesia. Seven patients who started with subpleural analgesia were treated with thoracic epidural analgesia at a mean (SD) of 3.9 (4.8) h. The remaining 14 patients had a median (IQR [range]) visual analogue score of 5 cm (4–5 [3–6]) at rest and were maintained on subpleural analgesia until the end of the study. The visual analogue score at rest was <7 cm in all 21 patients who received thoracic epidural analgesia and none was switched to subpleural analgesia during the study. None of the patients in the subpleural analgesia group experienced hypotension compared with five of the 21 patients in the thoracic epidural analgesia group (P = 0.047). Conclusion Thoracic epidural analgesia is superior to subpleural analgesia in relieving post-thoracotomy pain.
Recent Recombination Events in the Core Genome Are Associated with Adaptive Evolution in Enterococcus faecium

Reasons for the rising clinical impact of the bacterium Enterococcus faecium include the species’ rapid acquisition of adaptive genetic elements. Here, we focused on the impact of recombination on the evolution of E. faecium. We used the recently developed BratNextGen algorithm to detect recombinant regions in the core genome of 34 E. faecium strains, including three newly sequenced clinical strains. Recombination was found to have a significant impact on the E. faecium genome: of the original 1.2 million positions in the core genome, 0.5 million were predicted to have been affected by recombination in at least one strain. Importantly, strains in one of the two major E. faecium clades (clade B), which contains most of the E. faecium human gut commensals, formed the most important reservoir for donating foreign DNA to the second major E. faecium clade (clade A), which contains most of the clinical isolates. Also, several genomic regions were found to mainly recombine in specific hospital-associated E. faecium strains. One of these regions (the epa-like locus) likely encodes the biosynthesis of cell wall polysaccharides. These findings suggest a crucial role for recombination in the emergence of E. faecium as a successful hospital-associated pathogen.
The origin of the prion agent of kuru: molecular and biological strain typing

Kuru is an acquired human prion disease that primarily affected the Fore linguistic group of the Eastern Highlands of Papua New Guinea. The central clinical feature of kuru is progressive cerebellar ataxia and, in sharp contrast to most cases of sporadic Creutzfeldt–Jakob disease (CJD), dementia is a less prominent and usually late clinical feature. In this regard, kuru is more similar to variant CJD, which also has similar prodromal symptoms of sensory disturbance and joint pains in the legs and psychiatric and behavioural changes. Since a significant part of the clinicopathological diversity seen in human prion disease is likely to relate to the propagation of distinct human prion strains, we have compared the transmission properties of kuru prions with those isolated from patients with sporadic, iatrogenic and variant CJD in both transgenic and wild-type mice. These data have established that kuru prions have prion strain properties equivalent to those of classical (sporadic and iatrogenic) CJD prions but distinct from variant CJD prions. Here, we review these findings and discuss how peripheral routes of infection and other factors may be critical modifiers of the kuru phenotype.
A Hybrid Multi-Objective Optimization Framework for Preliminary Process Design Based on Health, Safety and Environmental Impact

Due to increasingly stringent legal requirements and escalating environmental control costs, chemical industries have paid close attention to sustainable development without compromising their economic performance. Thus, chemical industries are in need of systematic tools to conduct sustainability assessments of their process/plant design. In order to avoid making costly retrofits at later stages, assessments during the preliminary design stage should be performed. In this paper, a systematic framework is presented for chemical processes at the preliminary design stage. Gross profit, Health Quotient Index (HQI), Inherent Safety Index (ISI) and the Waste Reduction (WAR) algorithm are used to assess the economic performance, health, safety and environmental impact of the process, respectively. The fuzzy optimization approach is used to analyse the trade-off among the four aspects simultaneously, as they often conflict with each other. Deviation between the solution obtained from mathematical optimization model and process simulator is determined to ensure the validity of the model. To demonstrate the proposed framework, a case study on 1, 4-butanediol production is presented.
Effect of Low Level Subchronic Microwave Radiation on Rat Brain.

OBJECTIVE The present study was designed to investigate the effects of subchronic low level microwave radiation (MWR) on cognitive function, heat shock protein 70 (HSP70) level and DNA damage in brain of Fischer rats. METHODS Experiments were performed on male Fischer rats exposed to microwave radiation for 90 days at three different frequencies: 900, 1800, and 2450 MHz. Animals were divided into 4 groups: Group I: Sham exposed, Group II: animals exposed to microwave radiation at 900 MHz and specific absorption rate (SAR) 5.953 × 10-4 W/kg, Group III: animals exposed to 1800 MHz at SAR 5.835 × 10-4 W/kg and Group IV: animals exposed to 2450 MHz at SAR 6.672 × 10-4 W/kg. All the animals were tested for cognitive function using elevated plus maze and Morris water maze at the end of the exposure period and subsequently sacrificed to collect brain tissues. HSP70 levels were estimated by ELISA and DNA damage was assessed using alkaline comet assay. RESULTS Microwave exposure at 900-2450 MHz with SAR values as mentioned above lead to decline in cognitive function, increase in HSP70 level and DNA damage in brain. CONCLUSION The results of the present study suggest that low level microwave exposure at frequencies 900, 1800, and 2450 MHz may lead to hazardous effects on brain.
Error analysis of exponential integrators for oscillatory second-order differential equations

In this paper, we analyse a family of exponential integrators for second-order differential equations in which high-frequency oscillations in the solution are generated by a linear part. Conditions are given which guarantee that the integrators allow second-order error bounds independent of the product of the step size with the frequencies. Our convergence analysis generalizes
Dr. Pangloss restrained by the Red Queen : steps towards a unified defence theory

Animals and plants defend themselves against a variable community of biological enemies. We argue that the effectiveness of allocation to defence (the success of defence per unit allocation) may be expected to decrease as the diversity of attack types increases, and asked how the optimal allocation to defence covaries with the effectiveness of defence. Variation in effectiveness links optimal defence to coevolutionary processes; the prime characteristic of coevolutionary interactions is that they promote and maintain genetic variation in both hosts and their enemies, leading to variation in the effectiveness of defence. We present a simple model suggesting that as effectiveness decreases, the fitness benefit of defence disappears. In other words, when effectiveness is low, the optimal strategy is to tolerate damage. As effectiveness increases, the optimal allocation flips rapidly from no-defence (tolerance) to high allocation to defence, and then decreases at a decelerating pace as effectiveness increases. We conclude that diversifying coevolution, as it covaries with the effectiveness of defence, constrains the evolution of optimal defence strategies and may be a very important component in determining the optimal allocation to defence and variation in the success of defence as it is seen in the wild.
The Association between APOE Genotype and Memory Dysfunction in Subjects with Mild Cognitive Impairment Is Related to Age and Alzheimer Pathology

Background: Memory problems are a main feature of mild cognitive impairment (MCI) and may be related to the apolipoprotein E (APOE) Ε4 allele. We investigated whether the effect of the APOE genotype on memory in subjects with MCI was dependent on age and underlying Alzheimer disease (AD) pathology. Methods: Subjects with MCI (n = 180) were selected from a memory clinic setting. Subjects with at least one APOE Ε4 allele (n = 83) were compared to non-carriers on several memory measures. Subjects were reassessed 5–10 years later in order to identify those who developed AD. Results: In the middle-aged subgroup, the APOE Ε4 allele was most strongly related to decreased subjective organization and in the old subgroup to a decreased delayed recall. After excluding subjects with incipient AD (n = 33), results remained similar in the middle-aged subgroup, but in the old subgroup the APOE genotype was no longer associated with memory dysfunction. Conclusion: The presence of the APOE Ε4 allele is associated with impaired memory functioning in both middle-aged and old subjects with MCI, although the memory function affected varies with age. Its effect on memory function may be dependent on underlying AD pathology in elderly subjects, but not in middle-aged subjects.
Effectiveness of Dry Eye Therapy Under Conditions of Environmental Stress

Abstract Purpose: Dry eye is often characterized by increased tear evaporation due to poor tear film quality, especially of the lipid component of the tear film. Using an environmental chamber to induce environmental stress, this study compared the effect of three lubricant eye drops on various aspects of tear physiology in a crossover design (evaporation was the principal outcome measure). Methods: Three eye drop formulas were tested: 0.5% carmellose sodium (Drop C), 0.5% carmellose sodium with added lipid (Drop C-L) and 1.0% glycerine with added lipid (Drop G-L). Nineteen control and 18 dry eye subjects used each product for 2 weeks, three times per day, in a random order, with a minimum 1-week washout between treatment periods. Tear evaporation, break up time, osmolarity, tear structure (by interferometry) and patient symptoms were assessed with the subjects adapted for 10 min in an environmental chamber controlled at 20% relative humidity and 22 °C. The treatment effects were analyzed using general linear model repeated measures analyses of variance. Results: In dry eye subjects, evaporation, break up time, osmolarity and symptoms improved for all formulas (p < 0.05). Normal subjects showed some improvements: evaporation with C-L, osmolarity with C and symptoms with C-L and G-L. Change in evaporation was greater for both C-L and G-L versus C (p < 0.05), and there was a trend for C-L to reduce evaporation more than G-L (p < 0.11). There were no significant treatment effects on tear film structure. Conclusion: Overall, the eye drop formula containing both carmellose sodium and lipid (C-L) produced a greater treatment effect on tear evaporation than the other formulations containing only one of these ingredients. This study also demonstrates the utility of a controlled environmental chamber in showing the difference in performance between dry eye treatments.
Automatic Keyword Extraction from Documents Using Conditional Random Fields

Keywords are subset of words or phrases from a document that can describe the meaning of the document. Many text mining applications can take advantage from it. Unfortunately, a large portion of documents still do not have keywords assigned. On the other hand, manual assignment of high quality keywords is expensive, time-consuming, and error prone. Therefore, most algorithms and systems aimed to help people perform automatic keywords extraction have been proposed. Conditional Random Fields (CRF) model is a state-of-the-art sequence labeling method, which can use the features of documents more sufficiently and effectively. At the same time, keywords extraction can be considered as the string labeling. In this paper, keywords extraction based on CRF is proposed and implemented. As far as we know, using CRF model in keyword extraction has not been investigated previously. Experimental results show that the CRF model outperforms other machine learning methods such as support vector machine, multiple linear regression model etc. in the task of keywords extraction.
Mode of Action of Ticlopidine in Inhibition of Platelet Aggregation in the Rat

Summary Ticlopidine, when orally administered to rats, resulted in activation of basal and prostaglandin E1 (PGE1)-stimulated adenylate cylase activity through increase in affinity of the cyclase in platelet membrane to PGE1, although it failed to affect adenosine- or sodium fluoride-stimulated activity of the enzyme. In washed platelets, Ticlopidine also activated basal and PGE1-stimulated activity of the cyclase and prevented reduction in the cyclase activity caused by low concentrations of PGE2. Furthermore, Ticlopidine inhibited malondialdehyde formation in platelets induced by thrombin but failed to inhibit that caused by exogenous arachidonic acid. Adenosine 3’,5’-cyclic monophosphate (c-AMP): phosphodiesterase activity of platelet lysate was not significantly affected by Ticlopidine treatment. These findings indicate that Ticlopidine inhibits platelet aggregation and prostaglandin synthesis from endogenous substrate through activating basal and PGE1-stimulated activity of the cyclase, preventing PGE2-induced depression of the cyclase activity and thus increasing platelet c-AMP level.
Don't trust traceroute (completely)

In this work, we propose a methodology based on the alias resolution process to demonstrate that the IP level view of the route provided by traceroute may be a poor representation of the real router-level route followed by the traffic. More precisely, we show how the traceroute output can lead one to (i) inaccurately reconstruct the route by overestimating the load balancers along the paths toward the destination and (ii) erroneously infer routing changes.
Microclimate and Larval Habitat Density Predict Adult Aedes albopictus Abundance in Urban Areas

The Asian tiger mosquito, Aedes albopictus, transmits several arboviruses of public health importance, including chikungunya and Zika. Since its introduction to the United States in 1985, the species has invaded over forty states, including temperate areas not previously at risk of Aedes-transmitted arboviruses. Mathematical models incorporate climatic variables in predictions of site-specific Ae. albopictus abundances to identify human populations at risk of disease. However, these models rely on coarse resolutions of environmental data that may not accurately represent the climatic profile experienced by mosquitoes in the field, particularly in climatically-heterogeneous urban areas. In this study, we pair field surveys of larval and adult Ae. albopictus mosquitoes with site-specific microclimate data across a range of land use types to investigate the relationships between microclimate, density of larval habitat, and adult mosquito abundance and determine whether these relationships change across an urban gradient. We find no evidence for a difference in larval habitat density or adult abundance between rural, suburban, and urban land classes. Adult abundance increases with increasing larval habitat density, which itself is dependent on microclimate. Adult abundance is strongly explained by microclimate variables, demonstrating that theoretically derived, lab-parameterized relationships in ectotherm physiology apply to the field. Our results provide support for the continued use of temperature-dependent models to predict Ae. albopictus abundance in urban areas.
Extracting rare failure events in composite system reliability evaluation via subset simulation

Summary form only given. This paper proposes an efficient method for evaluating composite system reliability via subset simulation. The central idea is that a small failure probability can be expressed as a product of larger conditional probabilities, thereby turning the problem of simulating a rare failure event into several conditional simulations of more frequent intermediate failure events. In existing methods, system states are simply assessed in a binary secure/failure manner. To fit into the context of subset simulation, the adequacy of system states is parametrized with a metric based on linear programming, thus allowing for an adaptive choice of intermediate failure events. Samples conditional on these events are generated by Markov chain Monte Carlo simulation. The proposed method requires no prior information before simulation. Different models for renewable energy sources can also be accommodated. Numerical tests show that this method is significantly more efficient than standard Monte Carlo simulation, especially for simulating rare failure events.
Eye gaze estimation from a single image of one eye

We present a novel approach, called the "one-circle " algorithm, for measuring the eye gaze using a monocular image that zooms in on only one eye of a person. Observing that the iris contour is a circle, we estimate the normal direction of this iris circle, considered as the eye gaze, from its elliptical image. From basic projective geometry, an ellipse can be back-projected into space onto two circles of different orientations. However, by using an anthropometric property of the eyeball, the correct solution can be disambiguated. This allows us to obtain a higher resolution image of the iris with a zoom-in camera and thereby achieving higher accuracies in the estimation. The robustness of our gaze determination approach was verified statistically by the extensive experiments on synthetic and real image data. The two key contributions are that we show the possibility of finding the unique eye gaze direction from a single image of one eye and that one can obtain better accuracy as a consequence of this.
Vitamin D levels predict the response to cardiac resynchronization therapy in patients with systolic heart failure.

OBJECTIVE The aim of this study was to examine the relationship between vitamin D levels in patients with heart failure (HF) and response to cardiac resynchronization therapy (CRT). METHODS We studied 57 patients (mean age: 60.47±13.09 years) with New York Heart Association Class II or III heart failure, QRS duration ? 120 milliseconds, and ejection fraction <35% (mean: 27.1±4.4%) who underwent CRT. All patients were taking optimal medical treatment for HF. Patients were classified as CRT responders if they had >15% decrease in left ventricular end-systolic volume at 6 months compared with baseline measurements. Vitamin D levels were evaluated before CRT implantation with ELISA. RESULTS Of the 57 patients, 34 patients (59.6%) were classified as responders and 23 patients (40.4%) were classified as non-responders. Baseline features, laboratory findings, and echocardiographic characteristics were nearly the same in both groups. High vitamin D level was detected in responder group compared to non-responder group (26.17±7.5 ng/mL vs 21.15±5.9 ng/mL; p=0.009). Age, hypertension, diabetes mellitus, ischemic cardiomyopathy, QRS morphology and duration, and levels of B-type natriuretic peptide (BNP) and vitamin D were associated with CRT response in our study population. In multivariate regression analysis, preimplantation QRS duration, and BNP and vitamin D levels remained independent predictors (QRS duration Odds ratio [OR]: 1.047, CI: 1.019-1.417, p=0.006; BNP OR: 0.997, 95% CI: 0.994-0.999, p=0.029; vitamin D OR: 1.121, 95% CI: 1.011-1.242, p=0.030). CONCLUSION In the present study, preimplantation level of vitamin D was found to be predictor of response to CRT.
A Risk Assessment Framework for Automotive Embedded Systems

The automotive industry is experiencing a paradigm shift towards autonomous and connected vehicles. Coupled with the increasing usage and complexity of electrical and/or electronic systems, this introduces new safety and security risks. Encouragingly, the automotive industry has relatively well-known and standardised safety risk management practices, but security risk management is still in its infancy. In order to facilitate the derivation of security requirements and security measures for automotive embedded systems, we propose a specifically tailored risk assessment framework, and we demonstrate its viability with an industry use-case. Some of the key features are alignment with existing processes for functional safety, and usability for non-security specialists. The framework begins with a threat analysis to identify the assets, and threats to those assets. The following risk assessment process consists of an estimation of the threat level and of the impact level. This step utilises several existing standards and methodologies, with changes where necessary. Finally, a security level is estimated which is used to formulate high-level security requirements. The strong alignment with existing standards and processes should make this framework well-suited for the needs in the automotive industry.