Miracle-dz/UniFAR-FTUs huggingface dataset:
Utilization of automated external defibrillators installed in commonly used areas of Japanese hospitals

Objective. Since July 2004, it has become legal in Japan for laypersons to use automated external defibrillators (AEDs). We investigated the effect of AED installation in commonly used areas of Japanese Association for Acute Medicine accredited training (JAAM) hospitals. Methods. In 2008, we sent questionnaires to 419 JAAM hospitals enquiring about the systems, operations, outcome and characteristics of AED usage. Results. Valid responses were received from 271 hospitals (64.7%). A total of 251 (92.8%) hospitals installed AEDs, mostly in the outpatient departments. These AEDs could also be used by laypersons. Operational responsibility was mostly assumed by the medical emergency center staff. The Engineering Department was in charge of AED maintenance. Of the surveyed hospitals, 65.5% reported having guidelines for usage. The percentages of hospitals which kept records of AED use and outcomes were low. A total of 66.2% reported having a rapid response team and 98.1% provided a non-standardized resuscitation education program. In 68.3% of hospitals, an AED had been used. AEDs were used not only by medical doctors but also by other health professionals. Among the patients who received AED defibrillation, 42.5% survived without neurological deficit. Conclusion. The utilization of AEDs, installed in commonly used areas of JAAM hospitals, has shown beneficial and effective outcomes for improving the resuscitation and survival of patients who experience in-hospital cardiac arrest. AEDs can be used not only by doctors but also by laypersons, making them more accessible and useful. The strategic installation of AEDs can make hospitals safer.
Aberrant expression of aldehyde dehydrogenase 1A (ALDH1A) subfamily genes in acute lymphoblastic leukaemia is a common feature of T‐lineage tumours

The class 1A aldehyde dehydrogenase (ALDH1A) subfamily of genes encode enzymes that function at the apex of the retinoic acid (RA) signalling pathway. We detected aberrant expression of ALDH1A genes, particularly ALDH1A2, in a majority (72%) of primary paediatric T cell acute lymphoblastic leukaemia (T‐ALL) specimens. ALDH1A expression was almost exclusive to T‐lineage, but not B‐lineage, ALL. To determine whether ALDH1A expression may have relevance to T‐ALL cell growth and survival, the effect of inhibiting ALDH1A function was measured on a panel of human ALL cell lines. This revealed that T‐ALL proliferation had a higher sensitivity to modulation of ALDH1A activity and RA signalling as compared to ALL cell lines of B‐lineage. Consistent with these findings, the genes most highly correlated with ALDH1A2 expression were involved in cell proliferation and apoptosis. Evidence that such genes may be targets of regulation via RA signalling initiated by ALDH1A activity was provided by the TNFRSF10B gene, encoding the apoptotic death receptor TNFRSF10B (also termed TRAIL‐R2), which negatively correlated with ALDH1A2 and showed elevated transcription following treatment of T‐ALL cell lines with the ALDH1A inhibitor citral (3,7‐dimethyl‐2,6‐octadienal). These data indicate that ALDH1A expression is a common event in T‐ALL and supports a role for these enzymes in the pathobiology of this disease.
Infant and maternal health monitoring using a combined Nordic database on ART and safety

Objective. To evaluate infant and maternal health after assisted reproductive technology (ART), using data on over 90 000 ART children and their mothers in Denmark, Finland, Norway and Sweden. Data have been combined and will be compared with a control group of spontaneously conceived children and their mothers. The overall aim of this project is to evaluate the safety of ART. The size of the cohort should enable estimation of the prevalence of rare conditions such as birth defects, cancers, neurological impairments and imprinting diseases in the ART population compared to control children. Outcome data on the mothers of ART children can be used to study risks during pregnancy and obstetric complications after ART. Methods. A personal identification number given to all Nordic residents allows cross‐linkage of the national health registers and enables long‐term follow‐up of ART children. The medical birth registers in the Nordic countries make it possible to cross‐link data from mother and child. When a child is identified as conceived by ART, we can obtain a list of all International Classification of Diseases (ICD) codes ever registered on that specific child. Conclusion. Combining the Nordic ART and health registers is a complicated but feasible task. The main strengths of this ongoing study are the size of the cohort of ART children and their mothers and the possibility to follow the children through the health registers. The limitations are related to the national differences in reporting and recording of data together with the heterogeneity of data.
Is the Coefficient of Eddy Potential Vorticity Diffusion Positive? Part I: Barotropic Zonal Channel

The question of whether the coefficient of diffusivity of potential vorticity by mesoscale eddies is positive is studied for a zonally reentrant barotropic channel using the quasigeostrophic approach. The topography is limited to the first mode in the meridional direction but is unlimited in the zonal direction. We derive an analytic solution for the stationary (time independent) solution. New terms associated with parameterized eddy fluxes of potential vorticity appear both in the equations for the mean zonal momentum balance and in the kinetic energy balance. These terms are linked with the topographic form stress exerted by parameterized eddies. It is demonstrated that in regimes with zonal flow (analogous to the Antarctic Circumpolar Current), the coefficient of eddy potential vorticity diffusivity must be positive.
Histone Deacetylase Inhibition Enhances the Antitumor Activity of a MEK Inhibitor in Lung Cancer Cells Harboring RAS Mutations

Non–small cell lung cancer (NSCLC) can be identified by precise molecular subsets based on genomic alterations that drive tumorigenesis and include mutations in EGFR, KRAS, and various ALK fusions. However, despite effective treatments for EGFR and ALK, promising therapeutics have not been developed for patients with KRAS mutations. It has been reported that one way the RAS–ERK pathway contributes to tumorigenesis is by affecting stability and localization of FOXO3a protein, an important regulator of cell death and the cell cycle. This is through regulation of apoptotic proteins BIM and FASL and cell-cycle regulators p21Cip1 and p27Kip1. We now show that an HDAC inhibitor affects the expression and localization of FOXO proteins and wanted to determine whether the combination of a MEK inhibitor with an HDAC inhibitor would increase the sensitivity of NSCLC with KRAS mutation. Combined treatment with a MEK inhibitor and an HDAC inhibitor showed synergistic effects on cell metabolic activity of RAS-mutated lung cancer cells through activation of FOXOs, with a subsequent increase in BIM and cell-cycle inhibitors. Moreover, in a mouse xenograft model, the combination of belinostat and trametinib significantly decreases tumor formation through FOXOs by increasing BIM and the cell-cycle inhibitors p21Cip1 and p27Kip1. These results demonstrate that control of FOXOs localization and expression is critical in RAS-driven lung cancer cells, suggesting that the dual molecular-targeted therapy for MEK and HDACs may be promising as novel therapeutic strategy in NSCLC with specific populations of RAS mutations. Mol Cancer Ther; 17(1); 17–25. ©2017 AACR.
Contribution of angiotensin-converting enzyme to the cardiac metabolism of bradykinin: an interspecies study.

The role of angiotensin-converting enzyme (ACE) in the metabolism of bradykinin (BK) has been studied in several tissues. However, and contrary to angiotensin I, the metabolism of BK at the cardiac level has not been investigated. In this study, we define the participation of ACE in the carboxy-terminal degradation of BK in heart membranes of the dog, human, rabbit, and rat. The calculation of the kinetic parameters characterizing the metabolism of BK and the generated des-Arg9-BK can be summarized as follows: the half-life ( t 1/2) of BK [dog (218 ± 32 s) > human (143 ± 9 s) = rat (150 ± 4 s) > rabbit (22 ± 2 s)] and of des-Arg9-BK [dog (1,042 ± 40 s) > human (891 ± 87 s) > rat (621 ± 65 s) > rabbit (89 ± 8 s)] both showed significant differences according to species. Enalaprilat, an ACE inhibitor, significantly prevented the rapid degradation of BK and des-Arg9-BK in all species studied, whereas retrothiorphan, a neutral endopeptidase inhibitor, and losartan, an angiotensin II type I receptor antagonist, did not affect this metabolism. The relative importance of ACE in the cardiac metabolism of BK was species related: dog (68.4 ± 3.2%) = human (72.2 ± 2.0%) > rabbit (47.7 ± 5.0%) = rat (45.3 ± 3.9%). ACE participation in the metabolism of des-Arg9-BK was as follows: rabbit (57.0 ± 4.0%) > dog (39.9 ± 8.8%) = human (25.4 ± 5.5%) = rat (36.0 ± 7.0%). The participation of cardiac kininase I (carboxypeptidase M) in the transformation of BK into des-Arg9-BK was minor: human (2.6 ± 0.1%) > dog (0.9 ± 0.1%) = rabbit (1.0 ± 0.1%) = rat (1.0 ± 0.1%). These results demonstrate that ACE is the major BK-degrading enzyme in cardiac membranes. However, the metabolism of exogenous BK by heart membranes is species dependent. Our observations could explain some discrepancies regarding the contribution of kinins in the cardioprotective effects of ACE inhibitors.
Basilar-membrane responses to tones at the base of the chinchilla cochlea.

Basilar-membrane responses to single tones were measured, using laser velocimetry, at a site of the chinchilla cochlea located 3.5 mm from its basal end. Responses to low-level (< 10-20 dB SPL) characteristic-frequency (CF) tones (9-10 kHz) grow linearly with stimulus intensity and exhibit gains of 66-76 dB relative to stapes motion. At higher levels, CF responses grow monotonically at compressive rates, with input-output slopes as low as 0.2 dB/dB in the intensity range 40-80 dB. Compressive growth, which is significantly correlated with response sensitivity, is evident even at stimulus levels higher than 100 dB. Responses become rapidly linear as stimulus frequency departs from CF. As a result, at stimulus levels > 80 dB the largest responses are elicited by tones with frequency about 0.4-0.5 octave below CF. For stimulus frequencies well above CF, responses stop decreasing with increasing frequency: A plateau is reached. The compressive growth of responses to tones with frequency near CF is accompanied by intensity-dependent phase shifts. Death abolishes all nonlinearities, reduces sensitivity at CF by as much as 60-81 dB, and causes a relative phase lead at CF.
Copaiba Oil-Resin Treatment Is Neuroprotective and Reduces Neutrophil Recruitment and Microglia Activation after Motor Cortex Excitotoxic Injury

The oil-resin of Copaifera reticulata Ducke is used in the Brazilian folk medicine as an anti-inflammatory and healing agent. However, there are no investigations on the possible anti-inflammatory and neuroprotective roles of copaiba oil-resin (COR) after neural disorders. We have investigated the anti-inflammatory and neuroprotective effects of COR following an acute damage to the motor cortex of adult rats. Animals were injected with the neurotoxin N-Methyl-D-Aspartate (NMDA) (n = 10) and treated with a single dose of COR (400 mg/kg, i.p.) soon after surgery (Group 1) or with two daily doses (200 mg/kg, i.p.) during 3 days (Group 2) alter injury. Control animals were treated with vehicle only. COR treatment induced tissue preservation and decreased the recruitment of neutrophils and microglial activation in the injury site compared to vehicle animals. The results suggest that COR treatment induces neuroprotection by modulating inflammatory response following an acute damage to the central nervous system.
Epistemic and Statistical Probabilistic Ontologies

We present DISPONTE, a semantics for probabilistic ontologies that is based on the distribution semantics for probabilistic logic programs. In DISPONTE the axioms of a probabilistic ontology can be annotated with an epistemic or a statistical probability. The epistemic probability represents a degree of confidence in the axiom, while the statistical probability considers the populations to which the axiom is applied.
Effects of Decreasing Arterial Blood Pressure on Cerebral Blood Flow in the Baboon: INFLUENCE OF THE SYMPATHETIC NERVOUS SYSTEM

The influence of the sympathetic nervous system on the cerebral circulatory response to graded reductions in mean arterial blood pressure was studied in anesthetized baboons. Cerebral blood flow was measured by the 133Xe clearance method, and arterial blood pressure was decreased by controlled hemorrhage. In normal baboons, the constancy of cerebral blood flow was maintained until mean arterial blood pressure was approximately 65lpercent of the base-line value; thereafter, cerebral blood flow decreased when arterial blood pressure was reduced. Superior cervical sympathectomy of 2–3 weeks duration did not affect the normal response. In contrast, both acute surgical sympathectomy (cervical trunk division) and α-receptor blockade (1.5 mgsolkg of phenoxybenzamine) enhanced the maintenance of cerebral blood flow in the face of hemorrhagic hypotension in that cerebral blood flow did not decrease until mean arterial blood pressure was approximately 35percent of the base-line value. The results indicate that the sympathetic nervous system is not involved in the maintenance of cerebral blood flow in the face of a fall in arterial blood pressure. Indeed, the implication is that the sympathicoadrenal discharge accompanying hemorrhagic hypotension is detrimental to, rather than responsible for, cerebral autoregulation.
Weakly supervised semantic segmentation with a multi-image model

We propose a novel method for weakly supervised semantic segmentation. Training images are labeled only by the classes they contain, not by their location in the image. On test images instead, the method predicts a class label for every pixel. Our main innovation is a multi-image model (MIM) - a graphical model for recovering the pixel labels of the training images. The model connects superpixels from all training images in a data-driven fashion, based on their appearance similarity. For generalizing to new test images we integrate them into MIM using a learned multiple kernel metric, instead of learning conventional classifiers on the recovered pixel labels. We also introduce an “objectness” potential, that helps separating objects (e.g. car, dog, human) from background classes (e.g. grass, sky, road). In experiments on the MSRC 21 dataset and the LabelMe subset of [18], our technique outperforms previous weakly supervised methods and achieves accuracy comparable with fully supervised methods.
Age-Dependent Decline of Endogenous Pain Control: Exploring the Effect of Expectation and Depression

Although chronic pain affects all age ranges, it is particularly common in the elderly. One potential explanation for the high prevalence of chronic pain in the older population is impaired functioning of the descending pain inhibitory system which can be studied in humans using conditioned pain modulation (CPM) paradigms. In this study we investigated (i) the influence of age on CPM and (ii) the role of expectations, depression and gender as potential modulating variables of an age-related change in CPM. 64 healthy volunteers of three different age groups (young = 20–40 years, middle-aged = 41–60 years, old = 61–80 years) were studied using a classical CPM paradigm that combined moderate heat pain stimuli to the right forearm as test stimuli (TS) and immersion of the contralateral foot into ice water as the conditioning stimulus (CS). The CPM response showed an age-dependent decline with strong CPM responses in young adults but no significant CPM responses in middle-aged and older adults. These age-related changes in CPM responses could not be explained by expectations of pain relief or depression. Furthermore, changes in CPM responses did not differ between men and women. Our results strongly support the notion of a genuine deterioration of descending pain inhibitory mechanisms with age.
Dust-obscured star formation and the contribution of galaxies escaping UV/optical color selections at z~2

Context. A substantial amount of the stellar mass growth across cosmic time occurred within dust-enshrouded environments. So far, identification of complete samples of distant star-forming galaxies from the short wavelength range has been strongly biased by the effect of dust extinction. Nevertheless, the exact amount of star-forming activity that took place in high-redshift dusty galaxies but that has currently been missed by optical surveys has barely been explored. Aims. Our goal is to determine the number of luminous star-forming galaxies at 1.5 ≲ z ≲ 3 that are potentially missed by the traditional color selection techniques because of dust extinction. We also aim at quantifying the contribution of these sources to the IR luminosity and cosmic star formation density at high redshift. Methods. We based our work on a sample of 24 μm sources brighter than 80 μJy and taken from the Spitzer survey of the COSMOS field. Almost all of these sources have accurate photometric redshifts. We applied to this mid-IR selected sample the BzK and BM/BX criteria, as well as the selections of the IRAC peakers and the Optically-Faint IR-bright (OFIR) galaxies. We analyzed the fraction of sources identified with these techniques. We also computed 8 μm rest-frame luminosity from the 24 μm fluxes of our sources, and considering the relationships between L_(8μm) and L_(Pa_α) and between L_(8μm) and L_IR, we derived ρIR and then ρ_SFR for our MIPS sources. Results. The BzK criterion offers an almost complete (~90%) identification of the 24 μm sources at 1.4 < z < 2.5. In contrast, the BM/BX criterion misses 50% of the MIPS sources. We attribute this bias to the effect of extinction, which reddens the typical colors of galaxies. The contribution of these two selections to the IR luminosity density produced by all the sources brighter than 80 μJy are on the same order. Moreover the criterion based on the presence of a stellar bump in their spectra (IRAC peakers) misses up to 40% of the IR luminosity density, while only 25% of the IR luminosity density at z ~ 2 is produced by OFIR galaxies characterized by extreme mid-IR to optical flux ratios. Conclusions. Color selections of distant star-forming galaxies must be used with care given the substantial bias they can suffer. In particular, the effect of dust extinction strongly affects the completeness of identifications at the bright end of the bolometric luminosity function, which implies large and uncertain extrapolations to account for the contribution of dusty galaxies missed by these selections. In the context of forthcoming facilities that will operate at long wavelengths (e.g., JWST, ALMA, SAFARI, EVLA, SKA), this emphasizes the importance of minimizing the extinction biases when probing the activity of star formation in the early Universe.
Risk Factors for Microbial Bioburden During Daily Wear of Silicone Hydrogel Contact Lenses

Purpose: To assess risk factors associated with substantial microbial bioburden of lids, conjunctivae, contact lenses, and storage cases during daily wear of silicone hydrogel contact lenses. Methods: Two hundred eighteen patients were fit to lotrafilcon A lenses, randomized to use either a multipurpose solution or a hydrogen peroxide care system, and followed up for 1 year. Lenses, lens transport saline, lids, conjunctivae, and storage cases were cultured and considered to have substantial microbial bioburden when they harbored high levels of commensal or pathogenic organisms. Univariate and multivariate logistic regression analyses were conducted to examine which demographic covariates were associated with significant bioburden at each location while controlling for solution use. Results: In multivariate analyses, smoking trended toward an association with lens bioburden (odds ratio [OR]=2.15, 95% confidence interval [CI]: 0.95–4.88). Clerical occupations were found to be associated with more frequent overall storage case contamination (OR=3.51, 95% CI: 1.15–10.70) and, specifically, higher gram-positive storage case contamination (OR=5.57, 95% CI: 1.82–17.06). The peroxide system was associated with more frequent storage case contamination (OR=7.6, 95% CI: 3.79–15.19). Coagulase-negative staphylococci (CNS) were the most frequently cultured organisms within storage cases, and in multivariate analyses, CNS were more frequently found in storage cases of peroxide users (OR=6.12, 95% CI: 2.91–13.09). Conclusions: Clerical occupations were associated with increased microbial bioburden of storage cases during daily wear of silicone hydrogel lenses. Smoking may increase the risk of lens contamination. Storage cases are most frequently contaminated with normal skin flora, and peroxide cases were associated with more frequent contamination. However, the solution type was not associated with lid or lens contamination nor with corneal infiltrative events in this study.
Obesity, Serum Resistin and Leptin Levels Linked to Coronary Artery Disease

Background Clinical studies have demonstrated that adipocytokines play an important role in developing atherosclerotic cardiovascular diseases. Objective The aim of study was to evaluate the relationship between serum resistin and leptin levels with obesity and coronary artery disease (CAD). Methods In a cross-sectional study, we assessed the levels of serum resistin and leptin, C-reactive protein (CRP), lipid profile and cardiac enzyme tests (AST, CPK, LDH, CK-MB) in 40 CAD patients compared to 40 healthy controls. Anthropometric measurements including weight and height for calculating of body mass index (BMI), and waist circumference (WC) were performed for evaluation of obesity. Results CAD patients had increased levels of leptin and CRP, (p < 0.001), cholesterol (p < 0.05), triglyceride (p < 0.01), and WC (p < 0.05) compared to healthy controls. There was no statistical difference between CAD and control subjects for resistin (p = 0.058). In a multiple regression analysis, only an association between serum leptin with BMI (β = 0.480, p < 0.05) and WC (β = 1.386, p < 0.05) was found. Conclusions The findings suggest that leptin is a better marker of fat mass value than resistin and may be considered an independent risk factor for cardiac disorders that is largely dependent on obesity. However, further prospective studies are needed to confirm these results.
A Case Study: NLG meeting Weather Industry Demand for Quality and Quantity of Textual Weather Forecasts

In the highly competitive weather industry, demand for timely, accurate and personalized weather reports is always on the rise. In this paper we present a case study where Arria NLG and the UK national weather agency, the Met Office came together to test the hypothesis that NLG can meet the quality and quantity demands of a real-world use case.