Miracle-dz/UniFAR-FTUs huggingface dataset:
PREMEDICATION OF CHILDREN

Today the penal department and the psychiatric services Jive most harmoniously together (being nearly one and the same thing), and nearly all the advances Dr. Maddison has noted with respect to the mental hospitals are true for the prisons and prison hospitals. Similarly, all the various "groups" that he has enumerated as being practised in his province are equally practised within the penal framework.
Expert searcher, teacher, content manager, and patient advocate: an exploratory study of clinical librarian roles.

OBJECTIVE The research explored the roles of practicing clinical librarians embedded in a patient care team. METHODS Six clinical librarians from Canada and one from the United States were interviewed to elicit detailed descriptions of their clinical roles and responsibilities and the context in which these were performed. RESULTS Participants were embedded in a wide range of clinical service areas, working with a diverse complement of health professionals. As clinical librarians, participants wore many hats, including expert searcher, teacher, content manager, and patient advocate. Unique aspects of how these roles played out included a sense of urgency surrounding searching activities, the broad dissemination of responses to clinical questions, and leverage of the roles of expert searcher, teacher, and content manager to advocate for patients. CONCLUSIONS Detailed role descriptions of clinical librarians embedded in patient care teams suggest possible new practices for existing clinical librarians, provide direction for training new librarians working in patient care environments, and raise awareness of the clinical librarian specialty among current and budding health information professionals.
Type II Secretory Phospholipase A2 and Prognosis in Patients with Stable Coronary Heart Disease: Mendelian Randomization Study

Background Serum type II secretory phospholipase A2 (sPLA2-IIa) has been found to be predictive of adverse outcomes in patients with stable coronary heart disease. Compounds targeting sPLA2-IIa are already under development. This study investigated if an association of sPLA2-IIa with secondary cardiovascular disease (CVD) events may be of causal nature or mainly a matter of confounding by correlated cardiovascular risk markers. Methodology/Principal Findings Eight-year follow-up data of a prospective cohort study (KAROLA) of patients who underwent in-patient rehabilitation after an acute cardiovascular event were analysed. Associations of polymorphisms (SNP) in the sPLA2-IIa-coding gene PLA2G2A with serum sPLA2-IIa and secondary fatal or non-fatal CVD events were examined by multiple regression. Hazard ratios (HR) were compared with those expected if the association between sPLA2-IIa and CVD were causal. The strongest determinants of sPLA2-IIa (rs4744 and rs10732279) were associated with an increase of serum concentrations by 81% and 73% per variant allele. HRs (95% confidence intervals) estimating the associations of the SNPs with secondary CVD events were increased, but not statistically significant (1.16 [0.89–1.51] and 1.18 [0.91–1.52] per variant allele, respectively). However, these estimates were very similar to those expected when assuming causality (1.18 and 1.17), based on an association of natural log-transformed sPLA2-IIa concentration with secondary events with HR = 1.33 per unit. Conclusion The present findings regarding genetic polymorphisms, determination of serum sPLA2-IIa, and prognosis in CVD patients are consistent with a genuine causal relationship and thus might point to a valid drug target for prevention of secondary CVD events.
Hormone-Balancing Effect of Pre-Gelatinized Organic Maca (Lepidium peruvianum Chacon): (I) Biochemical and Pharmacodynamic Study on Maca using Clinical Laboratory Model on Ovariectomized Rats

Ovariectomized rats were used in a model laboratory study to examine biochemical and pharmacodynamic effects of pre-gelatinized organic preparation of Lepidium peruvianum Chacon (Maca-GO). Biochemical and Pharmacodynamic effects of Maca-GO (250 mg Maca-GO per kg body weight (bw) administered by intubation twice daily) were assessed in a 28 day model laboratory study on ovariectomized (by laparoscopy) Wistar rats with pharmacodynamic tests performed at the conclusion of the trial followed by blood collection for morphology and biochemical tests. Toxicity of Maca-GO used in the study was determined in bioassay on mice and rats. Anti-depressive function (Porsolt’s test) and anxiolytic sedative and cognitive effects (using elevated-plus maze, locomotor activity and passive avoidance tests) were assessed against control (laparotomized female rats with intact ovaries). In addition to blood morphology, the following blood serum constituents were analyzed: Estrogen (E2), Progesterone (PGS), Cortisol (CT), Adrenocorticotropic Hormone (ACTH), Thyroid Hormones (TSH, T3, and T4), Iron (Fe) and lipid profile (Triglycerides, Total Cholesterol, LDL, HDL). Analytically-determined non-toxic status of Maca-GO was confirmed in bioassays when applied to mice and rats at levels of 0.5 and up to 15mg/kg bw which shows it safe use in humans with the LD50>15 mg/kg bw. Maca-GO showed a distinctive, (P<0.05) antidepressant-like and sedative effect in ovariectomized rats only, while there was no anxiolytic activity nor disturbance of cognitive function observed in both, test and control animals. Observed in this study balancing effect of Maca-GO on sex hormone levels show its potential as a safe preparation for use in correcting physiological symptoms characteristic in postmenopausal stage with an indication of potentially even more value for its use in pre-menopausal women.
Headache and biomarkers predictive of vascular disease in a representative sample of US children.

OBJECTIVE To examine the association of childhood headache disorders with markers of risk for cardiovascular and cerebrovascular disease. DESIGN Information was collected on severe or recurrent headache or migraine in childhood or adolescence and on biomarkers predictive of vascular disease. SETTING The National Health and Nutrition Survey, a nationally representative health survey. PARTICIPANTS Children or adolescents aged 4 to 19 years (n = 11 770) who took part in the National Health and Nutrition Survey in 1999 through 2004. MAIN EXPOSURE Headache. MAIN OUTCOME MEASURES Body mass index; levels of C-reactive protein, homocysteine, serum and red blood cell folate, vitamin B(12), methylmalonic acid, total cholesterol, high-density lipoprotein cholesterol, non-high-density lipoprotein cholesterol, triglycerides, and uric acid; and platelet count. RESULTS Mean values for body mass index, C-reactive protein, and homocysteine were higher in children with than without headaches, and more children with headaches were in the highest quintile of risk for these factors. Serum and red blood cell folate levels were lower in children with headache. More children with headache were in the highest quintile of risk for 3 or more of these factors. CONCLUSIONS Several important risk factors for long-term vascular morbidity cluster in children and adolescents with severe or recurrent headache or migraine. Further study and screening of children with headaches may permit improved preventive management.
Theories in Intercultural Communication.

PART ONE: OVERVIEW On Theorizing Intercultural Communication - Young Kun Kim A Taxonomic Approach to Intercultural Communication - Larry E Sarbaugh PART TWO: CULTURE AND MEANING A Constructivist Theory of Communication and Culture - James L Applegate and Howard E Sypher Coordinated Management of Meaning - Vernon E Cronen, Victoria Chen, and W Barnett Pearce A Critical Theory Cultural Identity - Mary Jane Collier and Milt Thomas An Interpretive Perspective PART THREE: INTERCULTURAL BEHAVIOR Uncertainty and Anxiety - William B Gudykunst Communication Accommodation in Intercultural Encounters - Cynthia Gallois, Arlene Franklyn-Stokes, Howard Giles, and Nikolas Coupland Episode Representations in Intercultural Communication - Joseph P Forgas Intercultural Conflict Styles - Stella Ting-Toomey A Face-Negotiation Theory PART FOUR: INTERCULTURAL ADAPTATION Network Theory in Intercultural Communication - June Ock Yum A Theory of Adaptation in Intercultural Dyads - Huber W Ellingsworth The Convergence Theory and Intercultural Communication - D Lawrence Kincaid Intercultural Transformation - Young Kun Kim and Brent D Ruben A Systems Theory
Proteomic Analysis Reveals a Novel Function of the Kinase Sat4p in Saccharomyces cerevisiae Mitochondria

The Saccharomyces cerevisiae kinase Sat4p has been originally identified as a protein involved in salt tolerance and stabilization of plasma membrane transporters, implicating a cytoplasmic localization. Our study revealed an additional mitochondrial (mt) localization, suggesting a dual function for Sat4p. While no mt related phenotype was observed in the absence of Sat4p, its overexpression resulted in significant changes of a specific mitochondrial subproteome. As shown by a comparative two dimensional difference gel electrophoresis (2D-DIGE) approach combined with mass spectrometry, particularly two groups of proteins were affected: the iron-sulfur containing aconitase-type proteins (Aco1p, Lys4p) and the lipoamide-containing subproteome (Lat1p, Kgd2p and Gcv3p). The lipoylation sites of all three proteins could be assigned by nanoLC-MS/MS to Lys75 (Lat1p), Lys114 (Kgd2p) and Lys102 (Gcv3p), respectively. Sat4p overexpression resulted in accumulation of the delipoylated protein variants and in reduced levels of aconitase-type proteins, accompanied by a decrease in the activities of the respective enzyme complexes. We propose a regulatory role of Sat4p in the late steps of the maturation of a specific subset of mitochondrial iron-sulfur cluster proteins, including Aco1p and lipoate synthase Lip5p. Impairment of the latter enzyme may account for the observed lipoylation defects.
Awake reactivation predicts memory in humans

Significance How is new information converted into a memory trace? Here, we used functional neuroimaging to assess what happens to representations of new events after we first experience them. We found that a particular part of the medial temporal lobe, a brain region known to be critical for intact memory, spontaneously reactivates these events even when we are engaged in unrelated activities. Indeed, the extent to which such automatic reactivation occurs seems directly related to later memory performance. This finding shows that we can now study the dynamics of memory processes for specific experiences during the “offline” periods that follow the initial learning phase. How are new experiences transformed into memories? Recent findings have shown that activation in brain regions involved in the initial task performance reemerges during postlearning rest, suggesting that “offline activity” might be important for this transformation. It is unclear, however, whether such offline activity indeed reflects reactivation of individual learning experiences, whether the amount of event-specific reactivation is directly related to later memory performance, and what brain regions support such event-specific reactivation. Here, we used functional magnetic resonance imaging to assess whether event-specific reactivation occurs spontaneously during an active, postlearning delay period in the human brain. Applying representational similarity analysis, we found that successful recall of individual study events was predicted by the degree of their endogenous reactivation during the delay period. Within the medial temporal lobe, this reactivation was observed in the entorhinal cortex. Beyond the medial temporal lobe, event-specific reactivation was found in the retrosplenial cortex. Controlling for the levels of blood oxygen level-dependent activation and the serial position during encoding, the data suggest that offline reactivation might be a key mechanism for bolstering episodic memory beyond initial study processes. These results open a unique avenue for the systematic investigation of reactivation and consolidation of episodic memories in humans.
Implicit Surface-Based Geometric Fusion

This paper introduces a general purpose algorithm for reliable integration of sets of surface measurements into a single 3D model. The new algorithm constructs a single continuous implicit surface representation which is the zero-set of a scalar field function. An explicit object model is obtained using any implicit surface polygonization algorithm. Object models are reconstructed from both multiple view conventional 2.5D range images and hand-held sensor range data. To our knowledge this is the first geometric fusion algorithm capable of reconstructing 3D object models from noisy hand-held sensor range data.This approach has several important advantages over existing techniques. The implicit surface representation allows reconstruction of unknown objects of arbitrary topology and geometry. A continuous implicit surface representation enables reliable reconstruction of complex geometry. Correct integration of overlapping surface measurements in the presence of noise is achieved using geometric constraints based on measurement uncertainty. The use of measurement uncertainty ensures that the algorithm is robust to significant levels of measurement noise. Previous implicit surface-based approaches use discrete representations resulting in unreliable reconstruction for regions of high curvature or thin surface sections. Direct representation of the implicit surface boundary ensures correct reconstruction of arbitrary topology object surfaces. Fusion of overlapping measurements is performed using operations in 3D space only. This avoids the local 2D projection required for many previous methods which results in limitations on the object surface geometry that is reliably reconstructed. All previous geometric fusion algorithms developed for conventional range sensor data are based on the 2.5D image structure preventing their use for hand-held sensor data. Performance evaluation of the new integration algorithm against existing techniques demonstrates improved reconstruction of complex geometry.
High-rate distributed multi-source cooperation using complex field coding

A multisource cooperative protocol is developed capable of achieving diversity order up to the number of cooperating users at a high throughput. In this design each source jointly encodes its own new information symbol with the information symbols received from other sources at past instants. Joint encoding is done using linear complex-field coefficients. Throughput analysis shows gains with respect to existing multi-source protocols and approaches the throughput of non-cooperative schemes. Diversity analysis shows that full spatial diversity is achievable. Simulations confirm the analytically established assessments.
An Analysis of Natural T Cell Responses to Predicted Tumor Neoepitopes

Personalization of cancer immunotherapies such as therapeutic vaccines and adoptive T-cell therapy may benefit from efficient identification and targeting of patient-specific neoepitopes. However, current neoepitope prediction methods based on sequencing and predictions of epitope processing and presentation result in a low rate of validation, suggesting that the determinants of peptide immunogenicity are not well understood. We gathered published data on human neopeptides originating from single amino acid substitutions for which T cell reactivity had been experimentally tested, including both immunogenic and non-immunogenic neopeptides. Out of 1,948 neopeptide-HLA (human leukocyte antigen) combinations from 13 publications, 53 were reported to elicit a T cell response. From these data, we found an enrichment for responses among peptides of length 9. Even though the peptides had been pre-selected based on presumed likelihood of being immunogenic, we found using NetMHCpan-4.0 that immunogenic neopeptides were predicted to bind significantly more strongly to HLA compared to non-immunogenic peptides. Investigation of the HLA binding strength of the immunogenic peptides revealed that the vast majority (96%) shared very strong predicted binding to HLA and that the binding strength was comparable to that observed for pathogen-derived epitopes. Finally, we found that neopeptide dissimilarity to self is a predictor of immunogenicity in situations where neo- and normal peptides share comparable predicted binding strength. In conclusion, these results suggest new strategies for prioritization of mutated peptides, but new data will be needed to confirm their value.
Assessment of Cognitive Decline in Old Age with Brief Tests Amenable to Telephone Administration

The adequacy with which brief cognitive tests suitable for telephone administration can assess cognitive decline due to aging and Alzheimer’s disease is uncertain. The authors examined these issues with data from the Religious Orders Study, which involves annual clinical evaluations and brain donation at death. Participants are 996 older Catholic clergy members. Analyses focused on seven cognitive tests which can be administered in person or by telephone in less than 15 min. Composite measures of global cognition and of episodic, semantic and working memory were formed. During a mean of 5.8 years of follow-up, performance on each composite measure declined in persons with and without dementia at baseline. Among those without dementia, possession of the apolipoprotein E ε4 allele was associated with more rapid cognitive decline, especially in episodic and working memory. Level of performance on each cognitive measure proximate to death was inversely related to the level of cortical plaques and tangles in the brain. In a subset of persons who were given the tests by telephone, there was no evidence that performance differed from in-person administration. The results suggest that briefly assessing cognition with tests amenable to telephone administration may prove useful in longitudinal epidemiologic studies of older persons.
Abnormal anal cytology in high-risk human papilloma virus infection in HIV-infected Australians

Objective: To assess the prevalence of abnormal anal cytology and high-risk human papilloma virus (HPV)-type infection in HIV-infected people with a CD4 cell count >300 cells/μl. Methods: The clinic-based patient population included 126 HIV-infected people: 124 men who have sex with men, and two women (median age 45 years; CD4 cell count >300 cells/μl). Anal cytology swabs were placed into liquid-based medium for HPV typing by Hybrid Capture-2 assay and cytological assessment, by a single cytopathologist. Results: 106 (84%) participants were infected with high-risk HPV; 17 (14%) had no high-risk types of HPV detected; three (2%) had no HPV assay result because of an inadequate sample. Sixteen (13%) participants had cytological evidence of high-grade squamous intraepithelial (HGSIL) changes, 100% of whom had high-risk HPV types detected, and 13 (10%) had atypical squamous cells of undetermined significance with possible high-grade changes (ASCUS-H), 92% of whom had high-risk HPV types detected. Low-grade changes (LSIL) were detected in 24 (19%) participants, 96% of whom had high-risk HPV types, 32 (25%) had ASCUS with 88% high-risk HPV types, 30 (24%) had normal cytology with 73% high-risk HPV types, and 11 (9%) samples were inadequate for cytological assessment. The odds ratio of participants with high-risk HPV having abnormal anal cytology on anal swab was 5.03 (95% CI 1.45 to 17.39). Discussion: High-risk HPV types are common in this HIV+ population with a CD4 cell count >300 cells/μl. The presence of high-risk HPV types was associated with abnormal anal cytology such as HGSIL and ASCUS-H.
The Effect of Amplification on Cortical Synchrony in Children with Auditory Neuropathy Spectrum Disorder (ANSD)

The benefit of hearing aids as a clinical intervention strategy for children with Auditory Neuropathy Spectrum Disorder (ANSD) remains controversial. The goal of this study was to determine whether amplification through hearing aid use increases cortical phase synchrony in children with ANSD. Using inter-trial coherence (ITC) of the EEG signal as our measure of cortical phase-locking, we examined differences in cortical phase synchrony in children with ANSD using a cross-sectional design (n=58) and a longitudinal design (n=16). Results in the cross-sectional portion of the study revealed no significant difference in ITC between unaided and aided children. The longitudinal data revealed no significant increase in ITC over time with hearing aid use. Interestingly, half of the subjects in the longitudinal sample showed a significant decrease in ITC from the unaided to the aided conditions. Overall, our results suggest that hearing aids are not a beneficial intervention strategy for increasing neural synchrony in ANSD and that amplification may actually reduce cortical phase-locking in some children with ANSD.
The metabolomic profile of gamma-irradiated human hepatoma and muscle cells reveals metabolic changes consistent with the Warburg effect

The two human cell lines HepG2 from hepatoma and HMCL-7304 from striated muscle were γ-irradiated with doses between 0 and 4 Gy. Abundant γH2AX foci were observed at 4 Gy after 4 h of culture post-irradiation. Sham-irradiated cells showed no γH2AX foci and therefore no signs of radiation-induced double-strand DNA breaks. Flow cytometry indicated that 41.5% of HepG2 cells were in G2/M and this rose statistically significantly with increasing radiation dose reaching a plateau at ∼47%. Cell lysates from both cell lines were subjected to metabolomic analysis using Gas Chromatography-Mass Spectrometry (GCMS). A total of 46 metabolites could be identified by GCMS in HepG2 cell lysates and 29 in HMCL-7304 lysates, most of which occurred in HepG2 cells. Principal Components Analysis (PCA) showed a clear separation of sham, 1, 2 and 4 Gy doses. Orthogonal Projection to Latent Structures-Discriminant Analysis (OPLS-DA) revealed elevations in intracellular lactate, alanine, glucose, glucose 6-phosphate, fructose and 5-oxoproline, which were found by univariate statistics to be highly statistically significantly elevated at both 2 and 4 Gy compared with sham irradiated cells. These findings suggested upregulation of cytosolic aerobic glycolysis (the Warburg effect), with potential shunting of glucose through aldose reductase in the polyol pathway, and consumption of reduced Glutathione (GSH) due to γ-irradiation. In HMCL-7304 myotubes, a putative Warburg effect was also observed only at 2 Gy, albeit a lesser magnitude than in HepG2 cells. It is anticipated that these novel metabolic perturbations following γ-irradiation of cultured cells will lead to a fuller understanding of the mechanisms of tissue damage following ionizing radiation exposure.