Miracle-dz/UniFAR-FTUs huggingface dataset:
SecHOG: Privacy-Preserving Outsourcing Computation of Histogram of Oriented Gradients in the Cloud

Abundant multimedia data generated in our daily life has intrigued a variety of very important and useful real-world applications such as object detection and recognition etc. Accompany with these applications, many popular feature descriptors have been developed, e.g., SIFT, SURF and HOG. Manipulating massive multimedia data locally, however, is a storage and computation intensive task, especially for resource-constrained clients. In this work, we focus on exploring how to securely outsource the famous feature extraction algorithm--Histogram of Oriented Gradients (HOG) to untrusted cloud servers, without revealing the data owner's private information. For the first time, we investigate this secure outsourcing computation problem under two different models and accordingly propose two novel privacy-preserving HOG outsourcing protocols, by efficiently encrypting image data by somewhat homomorphic encryption (SHE) integrated with single-instruction multiple-data (SIMD), designing a new batched secure comparison protocol, and carefully redesigning every step of HOG to adapt it to the ciphertext domain. Explicit Security and effectiveness analysis are presented to show that our protocols are practically-secure and can approximate well the performance of the original HOG executed in the plaintext domain. Our extensive experimental evaluations further demonstrate that our solutions achieve high efficiency and perform comparably to the original HOG when being applied to human detection.
Short-Term Exercise Training Improves Insulin Sensitivity but Does Not Inhibit Inflammatory Pathways in Immune Cells from Insulin-Resistant Subjects

Background. Exercise has an anti-inflammatory effect against, and immune cells play critical roles in the development, of insulin resistance and atherosclerotic vascular disease (AVD). Thus, the goal of this study was to determine whether exercise improves insulin sensitivity in insulin-resistant subjects by downregulating proinflammatory signaling in immune cells. Methods. Seventeen lean, 8 obese nondiabetic, and 11 obese type 2 diabetic individuals underwent an aerobic exercise program for 15 days and an insulin clamp before and after exercise. Peripheral mononuclear cells (PMNC) were obtained for determination of Toll-like receptor (TLR) 2 and 4 protein content and mitogen-activated protein kinase phosphorylation. Results. Compared with that in lean individuals, TLR4 protein content was increased by 4.2-fold in diabetic subjects. This increase in TLR4 content was accompanied by a 3.0-fold increase in extracellular signal-regulated kinase (ERK) phosphorylation. Exercise improved insulin sensitivity in the lean, obese, and type 2 diabetes groups. However, exercise did not affect TLR content or ERK phosphorylation. Conclusions. TLR4 content and ERK phosphorylation are increased in PMNC of type 2 diabetic individuals. While exercise improves insulin sensitivity, this effect is not related to changes in TLR2/TLR4 content or ERK phosphorylation in PMNC of type 2 diabetic individuals.
Mutations in the Epstein-Barr virus latent membrane protein-1 (BNLF-1) gene in spontaneous lymphoblastoid cell lines: effect on in vitro transformation associated parameters and tumorigenicity in SCID and nude mice

Aims—(1) To study the frequency of putative malignancy associated point mutations and a 30 base pair (bp) deletion in exon 3 of the C-terminus of the Epstein-Barr virus (EBV) encoded latent membrane protein (LMP)-1 (BNLF-1) gene in wild type EBV strains. (2) To assess the influence of these mutations on the tumorigenicity of lymphoblastoid cell lines (LCL). Methods—Eight spontaneous EBV (wild type) infected LCL were established from seven subjects. Deletions and single base mutations in the C-terminus of the BNLF-1 gene were demonstrated using bi-directional solid phase dideoxy sequencing following PCR amplification of viral DNA from the LCL. Tumorigenicity of the LCL was assessed in SCID and nude mice. Serum dependent growth and ability to form colonies in soft agarose were assessed for representative LCL. Results—All LCL showed sequence differences compared with the prototypic EBV strain B95-8. The 30 bp deletion could be detected in three of eight LCL and a 69 bp deletion (including the 30 bp deletion) was identified in an additional LCL. A range of single base mutations (including those described previously in association with EBV related neoplasias) was also seen in some of the LCL. In transformation studies, the genetic variations did not seem to influence the in vitro behaviour of the LCL. In the tumorigenicity studies, the presence of the 30 bp deletion had no influence on the behaviour of the LCL which were, as expected, tumorigenic in SCID mice but not in nude mice. In contrast, the LCL carrying the 69 bp deletion was tumorigenic in both SCID and nude mice. Conclusions—Genetic changes described previously in the C-terminus of the LMP-1 gene in various malignancy derived EBV strains are also present frequently in wild type viruses and do not simply define tumour specific EBV strains. Changes within this region may, however, still be important for the tumorigenicity of LMP-1 and thus play a role in EBV oncogenesis.
Metabolic fingerprinting to understand therapeutic effects and mechanisms of silybin on acute liver damage in rat

Background: Metabolic fingerprinting is a rapid and noninvasive analysis, representing a powerful approach for the characterization of phenotypes and the distinction of specific metabolic states due to environmental alterations. It has become a valuable analytical approach for the characterization of phenotypes and is the rapidly evolving field of the comprehensive measurement of ideally all endogenous metabolites in bio-samples. Silybin has displayed bright prospects in the prevention and therapy of liver injury, and we had conducted a preliminary exploration on the molecular mechanism of the hepatoprotective effects of silybin. Because the knowledge on the metabolic responses of an acute liver damage rat to the silybin is still scarce, metabolic fingerprinting can provide relevant information on the intrinsic metabolic adjustments. Materials and Methods: Here, the physiological and metabolic changes in the acute liver damage rat were investigated by performing a metabolic analysis. The phenotypic response was assessed by liquid chromatography/mass spectrometry (LC/MS) combined with pattern recognition approaches such as principal components analysis and partial least squares projection to supervised latent structures and discriminant analysis. Multivariate analysis of the data showed trends in scores plots that were related to the concentration of the silybin. Results: Results indicate 10 ions (7 upregulated and 3 downregulated) as differentiating metabolites. Key observations include perturbations of metabolic pathways linked to glutathione metabolism, tryptophan metabolism, cysteine and methionine metabolism, etc., Overall, this investigation illustrates the power of the LC/MS combined with the pattern recognition methods that can engender new insights into silybin affecting on metabolism pathways of an acute liver damage rat. Conclusion: The present study demonstrates that the combination of metabolic fingerprinting with appropriate chemometric analysis is a valuable approach for studying cellular responses to silybin drug and can provide additional insight into the mechanisms.
Proposing Geo-Products for Ly Son Geopark, Vietnam

Ly Son district includes two off-shore volcanic islands: Ly Son Island (Re Isle) and Little Island (Bo Bai Isle), located in the eastern part of Quang Ngai Province, central Vietnam. It covers approximately 9.97 km2 of land. Ly Son and the surrounding area will be applying to become a UNESCO Global Geopark. The island district is a product of volcanic activity that creates a wide variety of geomorphology forms: modern marine deposition, marine sediment, basalt flow and volcanic eruptions, and other geo-features. As a result of the geosite inventory, together with the assessment of scientific value and additional values (ecology, culture/history, economics, aesthetics), this study was conducted to propose a wide range of geo-products for Ly Son Geopark. The suggested products include: tourist center; scientific interpretation services such as introduction, providing explanations of scientific values of Ly Son Geopark; geo-trails, geo-roads, and geo-adventures; as well as local products. Geo-products will definitely contribute to support local economic development, appealing to tourists and effectively enhancing Earth Sciences education and conservation.
Initial success of native grasses is contingent on multiple interactions among exotic grass competition, temporal priority, rainfall and site effects

Throughout the western United States, native perennial grasses are being supplanted by aggressive non-native annuals. We show that giving native grasses just a two-week germination 'head start' over exotic invasive grasses shifts the competitive edge strongly in their favour. We also show that the strength of this advantage differs strikingly depending on the site where the experiment is carried out, and the weather in the initial weeks of the experiment. These results a) give insight into the reasons for the competitive advantage that annuals usually demonstrate, and b) are an example of the likelihood that ecological experiments often produce results that are limited to a particular time and place, and less general than we might wish to believe.
Dual-Band Coaxial Cavity Bandpass Filter With Helical Feeding Structure and Mixed Coupling

In this letter, stepped-impedance resonators are used in coaxial cavity filter to generate dual-band response. Two key merits of the proposed filter are the helical feeding structure and the introduction of mixed coupling for coupling control and generation of transmission zero. The helical feeding structure makes it possible to conveniently control the external quality factors of two bands. To illustrate the concept, a third-order dual-band coaxial cavity filter is designed, fabricated and measured. The measured results are in good agreement with the full-wave simulation results.
Purification and Identification of a 42-Kilodalton Abscisic Acid-Specific-Binding Protein from Epidermis of Broad Bean Leaves 1

Purification of abscisic acid (ABA)-binding proteins is considered to constitute a major step toward isolating ABA receptors. We report here that an ABA-binding protein was for the first time, to our knowledge, purified from the epidermis of broad bean (Vicia faba) leaves via affinity chromatography. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis, isoelectric focusing electrophoresis, and isoelectric focusing/sodium dodecyl sulfate-polyacrylamide gel electrophoresis twodimensional electrophoresis of the purified ABA-binding protein all identified a single protein band with a molecular mass of 42 kD and an isoelectric point 4.86. The Scatchard plot for the purified protein showed a linear function with a maximum binding activity of 0.87 mol mol 1 protein and an equilibrium dissociation constant of 21 nm, indicating that the purified protein may be a monomeric one, possessing one binding site. The ABA-binding protein was enriched more than 300-fold with a yield of 14%. ( )ABA and trans-ABA were substantially incapable of displacing H-( )ABA bound to the ABAbinding protein, and ( )ABA was less effective than ( )ABA in the competition. These findings allow establishment of the stereospecificity of the 42-kD protein and suggest its ABA receptor nature. Pretreatment of the guard cell protoplasts of broad bean leaves with the monoclonal antibody raised against the 42-kD protein significantly decreased the ABA specific-induced phospholipase D activity in a dose-dependent manner. This physiological significance provides more clear evidence for the potential ABA-receptor nature of the 42-kD protein.
From Bows to Arrows: Rolling Shutter Rectification of Urban Scenes

The rule of perspectivity that 'straight-lines-mustremain-straight' is easily inflected in CMOS cameras by distortions introduced by motion. Lines can be rendered as curves due to the row-wise exposure mechanism known as rolling shutter (RS). We solve the problem of correcting distortions arising from handheld cameras due to RS effect from a single image free from motion blur with special relevance to urban scenes. We develop a procedure to extract prominent curves from the RS image since this is essential for deciphering the varying row-wise motion. We pose an optimization problem with line desirability costs based on straightness, angle, and length, to resolve the geometric ambiguities while estimating the camera motion based on a rotation-only model assuming known camera intrinsic matrix. Finally, we rectify the RS image based on the estimated camera trajectory using inverse mapping. We show rectification results for RS images captured using mobile phone cameras. We also compare our single image method against existing video and nonblind RS rectification methods that typically require multiple images.
Quality deviations in cancer diagnosis: prevalence and time to diagnosis in general practice.

BACKGROUND High quality in every phase of cancer diagnosis is important to optimise the prognosis for the patient. General practice plays an important role in this phase. AIM The aim was to describe the prevalence and the types of quality deviations (QDs) that arise during the diagnostic pathway in general practice as assessed by GPs and to analyse the association between these QDs, the cancer type, and the GP's interpretation of presenting symptoms as well as the influence on the diagnostic interval. DESIGN AND SETTING A Danish retrospective cohort study based on questionnaire data from 1466 GPs on 5711 incident patients with cancer identified in the Danish National Patient Registry (response rate = 71.4%). The GP was involved in diagnosing in 4036 cases. METHOD Predefined QDs were prompted with the possibility for free text. QD prevalence was estimated as was the association between QDs and diagnosis, the GP's symptom interpretation, and time to diagnosis. RESULTS QDs were present for 30.4% (95% confidence interval [CI] = 29.0 to 31.9) of cancer patients. The most prevalent QD was 'retrospectively, one or more of my clinical decisions were less optimal'. QDs were most prevalent among patients with vague symptoms (24.1% for alarm symptoms versus 39.5% for vague symptoms [P<0.001]). QD presence implied a 41-day (95% CI = 38.4 to 43.6) longer median diagnostic interval. CONCLUSION GPs noted at least one QD, which often involved clinical decisions, for one-third of all cancer patients. QDs were more likely among patients with vague symptoms and increased the diagnostic interval considerably.
Chlamydomonas FAP133 is a dynein intermediate chain associated with the retrograde intraflagellar transport motor

Intraflagellar transport (IFT) is the bi-directional movement of particles along the length of axonemal outer doublet microtubules and is needed for the assembly and maintenance of eukaryotic cilia and flagella. Retrograde IFT requires cytoplasmic dynein 1b, a motor complex whose organization, structural composition and regulation is poorly understood. We have characterized the product of the Chlamydomonas FAP133 gene that encodes a new WD-repeat protein similar to dynein intermediate chains and homologous to the uncharacterized vertebrate protein WD34. FAP133 is located at the peri-basal body region as well as in punctate structures along the flagella. This protein is associated with the IFT machinery because it is specifically depleted from the flagella of cells with defects in anterograde IFT. Fractionation of flagellar matrix proteins indicates that FAP133 associates with both the LC8 dynein light chain and the IFT dynein heavy chain and light intermediate chain (DHC1b-D1bLIC) motor complex. In the absence of DHC1b or D1bLIC, FAP133 fails to localize at the peri-basal body region but, rather, is concentrated in a region of the cytoplasm near the cell center. Furthermore, we found that FAP133, LC8, DHC1b, D1bLIC, the FLA10 kinesin-2 necessary for anterograde IFT and other IFT scaffold components associate to form a large macromolecular assembly.
Investigation of a Generalized Nonlinear Form of the Complementary Principle for Evaporation Estimation

A generalized nonlinear form of the complementary principle for evaporation estimation was tested against evaporation measurements from seven flux stations in China representing different climatic conditions and ecosystem types. The method was implemented using routine meteorological data and pan evaporation measurements. The results indicate that the generalized nonlinear form with its regular boundary conditions can accurately estimate daily evaporation; its performance was somewhat better when the atmospheric evaporative demand was determined from the Penman equation than from pan evaporation. In addition, two formulations of the generalized nonlinear form, namely, a basic formulation and a more flexible quartic formulation, were compared. The comparisons indicate that the quartic formulation is not necessary and may only be needed possibly to accommodate unusual situations. The results should further advance and facilitate the application of the generalized nonlinear form to estimate daily evaporation; since only routine meteorological data are required as input, the method should be useful to generate long time series and their trends, wherever such data are available.
Optimal and Near-Optimal Signal Detection in Snapping Shrimp Dominated Ambient Noise

The optimal detection of signals requires detailed knowledge of the noise statistics. In many applications, the assumption of Gaussian noise allows the use of the linear correlator (LC), which is known to be optimal in these circumstances. However, the performance of the LC is poor in warm shallow waters where snapping shrimp noise dominates in the range 2-300 kHz. Since snapping shrimp noise consists of a large number of individual transients, its statistics are highly non-Gaussian. We show that the noise statistics can be described accurately by the symmetric alpha-stable family of probability distributions. Maximum-likelihood (ML) and locally optimal detectors based on the detailed knowledge of the noise probability distribution are shown to demonstrate enhanced performance. We also establish that the sign correlator, which is a nonparametric detector, performs better than the LC in snapping shrimp noise. Although the performance of the sign correlator is slightly inferior to that of the ML detector, it is very simple to implement and does not require detailed knowledge of the noise statistics. This makes it an attractive compromise between the simple LC and the complex ML detector
Toxic effects of spinosad on predatory insects

Spinosad (Dow AgroSciences) is a mixture of tetracyclic-macrolide compounds produced by a soil actinomycete and has been classified as a bioinsecticide. Spinosad is highly active against Lepidoptera but is reported to be practically nontoxic to insect natural enemies. We assessed the impact of Spinosad in a granular maize-flour formulation on a selection of insect predators over periods of 2‐14 days. In all cases, the quantities of Spinosad used were less than the maximum recommended rates given on the product label. Adults of Aleochara bilineata Gyllenhal (Coleoptera: Staphylinidae) suffered a high prevalence of mortality following consumption of 1000 or 2000 ppm Spinosad active ingredient (a.i.), but little mortality at 200 ppm. Larvae of Chrysoperla carnea (Stephens) (Neuroptera: Chrysopidae) did not consume the granular formulation and suffered little overall mortality. After 14 days of exposure, the earwig, Doru taeniatum (Dohrn) (Dermaptera:Forficulidae), suffered 48% mortality in the 1.2 ppm Spinosad treatment increasing to 98% in the 1200 ppm Spinosad treatment compared to 20% in controls. Earwigs suffered 86% mortality/intoxication 72 h after feeding on Spinosad-contaminated Spodoptera frugiperda J. E. Smith (Lepidoptera:Noctuidae) larvae. A field trial was performed to compare applications of commercial granular chlorpyrifos and Spinosad in maize-flour granules (200 and 2000 ppm a.i.; 4.8 ‐ 48 g a.i./ha, respectively) or as an aqueous spray (160 ppm a.i.; 48 g a.i./ha) on earwigs held inside gauze bags. Mortality of earwigs on control plants was less than 15% at 2 days postapplication compared to 33% on plants treated with granular chlorpyrifos, 83% on plants sprayed with 160 ppm Spinosad, and 91‐95% on plants treated with 200 ‐2000 ppm Spinosad granules, respectively. Further mortality in the 24-h period postsampling ranged from <5% in control treatments, to 9% in the chlorpyrifos treatment, and to 55‐ 65% in the Spinosad spray and granule treatments. We conclude that Spinosad cannot be considered to have an
An Exocellular Protein from the Oil-Degrading Microbe Acinetobacter venetianus RAG-1 Enhances the Emulsifying Activity of the Polymeric Bioemulsifier Emulsan

ABSTRACT The oil-degrading microorganism Acinetobacter venetianus RAG-1 produces an extracellular polyanionic, heteropolysaccharide bioemulsifier termed emulsan. Emulsan forms and stabilizes oil-water emulsions with a variety of hydrophobic substrates. Removal of the protein fraction yields a product, apoemulsan, which exhibits much lower emulsifying activity on hydrophobic substrates such as n-hexadecane. One of the key proteins associated with the emulsan complex is a cell surface esterase. The esterase (molecular mass, 34.5 kDa) was cloned and overexpressed in Escherichia coli BL21(DE3) behind the phage T7 promoter with the His tag system. After overexpression, about 80 to 90% of the protein was found in inclusion bodies. The overexpressed esterase was recovered from the inclusion bodies by solubilization with deoxycholate and, after slow dialysis, was purified by metal chelation affinity chromatography. Mixtures containing apoemulsan and either the catalytically active soluble form of the recombinant esterase isolated from cell extracts or the solubilized inactive form of the enzyme recovered from the inclusion bodies formed stable oil-water emulsions with very hydrophobic substrates such as hexadecane under conditions in which emulsan itself was ineffective. Similarly, a series of esterase-defective mutants were generated by site-directed mutagenesis, cloned, and overexpressed in E. coli. Mutant proteins defective in catalytic activity as well as others apparently affected in protein conformation were also active in enhancing the apoemulsan-mediated emulsifying activity. Other proteins, including a His-tagged overexpressed esterase from the related organism Acinetobacter calcoaceticus BD4, showed no enhancement.