Miracle-dz/UniFAR-FTUs huggingface dataset:
Fitness based Mutation in Artificial Bee Colony Algorithm

Artificial Bee Colony (ABC) optimization algorithm is a swarm intelligence based nature inspired algorithm which has been proved a competitive algorithm with some popular nature-inspired algorithms. However, it is found that the ABC algorithm prefers exploration at the cost of the exploitation. Therefore, in this paper a self adaptive fitness based mutation strategy is presented in which the perturbation in the solution is based on fitness of the solution. The proposed strategy is self-adaptive in nature and therefore no manual parameter setting is required.
Process models: Neutral ground for collaboration, but power matters

Models and other process visualizations are common artifacts in organizations to visualize, analyze and sustain processes. They also serve as artifacts for communication. In these settings, models serve as neutral ground taking away anxieties usually arising when different parties work together. Models can also become tools of power enabling inferior participants to state their opinion or becoming tools superior participants want to control. Facilitation of model usage and development can give room to the positive aspects of this usage and diminish possible downsides. This paper deals with the question whether these effects can also be achieved in situations in which people use models on their own. As we found in a study, some of these effects are present without facilitation, but there is some work remaining to support all of them in practice.
The Neural Integration of Speaker and Message

When do listeners take into account who the speaker is? We asked people to listen to utterances whose content sometimes did not match inferences based on the identity of the speaker (e.g., If only I looked like Britney Spears in a male voice, or I have a large tattoo on my back spoken with an upper-class accent). Event-related brain responses revealed that the speaker's identity is taken into account as early as 200300 msec after the beginning of a spoken word, and is processed by the same early interpretation mechanism that constructs sentence meaning based on just the words. This finding is difficult to reconcile with standard Gricean models of sentence interpretation in which comprehenders initially compute a local, context-independent meaning for the sentence (semantics) before working out what it really means given the wider communicative context and the particular speaker (pragmatics). Because the observed brain response hinges on voice-based and usually stereotype-dependent inferences about the speaker, it also shows that listeners rapidly classify speakers on the basis of their voices and bring the associated social stereotypes to bear on what is being said. According to our event-related potential results, language comprehension takes very rapid account of the social context, and the construction of meaning based on language alone cannot be separated from the social aspects of language use. The linguistic brain relates the message to the speaker immediately.
Collaborative cloud computing adoption in Australian regional municipal government: An exploratory study

Cloud computing is seen as an increasingly important enabler for improving productivity, efficiency and cost reduction. This research aims to identify factors that are perceived likely to influence the adoption of cloud computing for Australian municipal governments. The research model draws from the technology-organization-environment (TOE) framework and the diffusion of innovation (DOI) model. The research employed in-depth interviews of Australian councils' IT managers. The main factors that were identified as playing a significant role in Australian local council's adoption of cloud services were: relative advantage, compatibility, cost, technology readiness, competitive pressure.
The Effect of Subcutaneous Platelet-Rich Plasma Injection on Viability of Auricular Cartilage Grafts

Introduction:Although cartilage grafts are frequently used for structural integrity and volume restoration, one of the main concerns dealing with cartilage grafting is gradual volume loss and unpredictable viability rates of cartilage grafts. Platelet-rich plasma (PRP) is a well known platelet concentrate reported to enhance cartilage repair and stimulates chondrocyte proliferation and matrix biosynthesis. The purpose of the current study was to investigate the effect of subcutaneous PRP injection on improving the viability of cartilage grafts. Materials and Methods:Six circular cartilage grafts were obtained from auricular cartilages of 6 New Zealand white rabbits. Cartilage grafts were prepared in 3 forms: block, crushed, and crushed/wrapped with Surgicel (Surgical, Ethicon, Somerville, NJ). Grafts were placed to 6 dorsal subcutaneous pockets and pockets were closed. Autologous PRP was prepared and injected subcutaneously into the pockets of experiment groups. At the end of 8 weeks, cartilage grafts were removed. Cartilage mass reduction rates were measured. Resorption rates of cartilage grafts and formation of fibroelastic and bone tissue were microscopically evaluated. Results:All of the cartilage grafts lost significant weight. Viability scores of block cartilages were higher than crushed cartilages. Although less weight loss rates and higher histopathologic scores were obtained in subcutaneously PRP injected cartilage graft groups, these results were not statistically significant. Conclusions:Although our study gives a new insight about increasing the viability of cartilage grafts, the subcutaneous PRP injection did not result in improving the viability of cartilage grafts in this experimental design.
Association of psychological risk factors and acute myocardial infarction in China: the INTER-HEART China study.

BACKGROUND Most data about psychological factors relating to acute myocardial infarction (AMI) were obtained from studies carried out in western countries. Results from small descriptive cross-sectional studies in China were inconclusive. The aim of this study was to explore possible associations between psychological risk factors and AMI among the Chinese population with a large-scale case-control study. METHODS This study was part of the INTER-HEART China study, itself part of the large international INTER-HEART study of cardiovascular risk factors. In this case-control study, 2909 cases and 2947 controls were recruited from 17 cities. Psychological stress, negative life events, depression and controllability of life circumstances were assessed. RESULTS Cases reported more psychological stress at home or work and odds ratios (ORs) were 3.2 (95%CI 2.1 - 4.9) for permanent stress and 2.1 (95%CI 1.5 - 2.8) for several periods of stress respectively. More cases experienced depression compared with controls (19.6% vs. 9.3%) and ORs were 2.2 (95%CI 1.9 - 2.6). Subjects with 1, 2 and 3 or more depressive symptoms had increased risk of AMI by 2.1, 2.2 and 2.6 fold, respectively, i.e., more depressive symptoms were associated with higher risks of AMI (P for trend < 0.0001). Women had a greater risk of AMI from depression (OR 3.0, 95%CI 2.2 - 4.0) compared to men (OR 2.0, 95%CI 1.6 - 2.4), P for interaction = 0.0364. Negative life events in subjects were associated with increased risk of AMI, OR 1.7 (95%CI 1.4 - 2.0) for one event and 1.8 (95%CI 1.3 - 2.4) for two or more events. High levels of controllability of life circumstances reduced the risk for AMI (OR 0.8, 95%CI 0.7 - 1.0). CONCLUSIONS Several psychological factors were closely associated with increased AMI risk among Chinese population. Psychological stress had a greater AMI risk in men but depression was more significant among women.
Is single-unit blood transfusion bad post-coronary artery bypass surgery?

OBJECTIVES Publications in the surgical literature are very consistent in their conclusions that blood is dangerous with regard to in-hospital mortality, morbidity and long-term survival. Blood is frequently used as a volume expander while simultaneously increasing the haematocrit. We investigated the effects of a single-unit blood transfusion on long-term survival post-cardiac surgery in isolated coronary artery bypass grafting patients. METHODS A prospective single-institution cardiac surgery database was analysed involving 4615 patients. Univariate, multivariate stepwise Cox regression analysis and propensity matching were performed to identify whether a single-unit blood transfusion was detrimental to long-term survival. RESULTS Univariate analysis revealed that blood was significantly associated with a reduced long-term survival even with a single-unit transfused, P = 0.0001. Cox multivariate regression analysis identified age, ejection fraction, preoperative dialysis, logistic EuroSCORE, postoperative CKMB, blood transfusion, urgent operative status and atrial fibrillation as significant factors determining long-term survival. When the Cox regression was repeated with patients who received no blood or only one unit of blood, transfusion was not a risk factor for long-term survival. An interaction analysis revealed that blood transfusion was significantly interacting with preoperative haemoglobin levels, P = 0.02. Propensity analysis demonstrated that a single-unit transfusion is not associated with a detrimental long-term survival, P = 0.3. CONCLUSIONS Cox regression and propensity matching both indicate that a single-unit transfusion is not a significant cause of reduced long-term survival. Preoperative anaemia is a significant confounding factor. Despite demonstrating the negligible risks of a single-unit blood transfusion, we are not advocating liberal transfusion and would recommend changing from a double-unit to a single-unit transfusion policy. We speculate that blood is not bad, but that the underlying reason that it is given might be.
Compatibility of Shelah and Stupp's and Muchnik's iteration with fragments of monadic second order logic

We investigate the relation between the theory of the iterations in the sense of Shelah-Stupp and of Muchnik, resp. , and the theory of the base structure for several logics. These logics are obtained from the restriction of set quantification in monadic second order logic to certain subsets like, e.g., finite sets, chains, and finite unions of chains. We show that these theories of the Shelah-Stupp iteration can be reduced to corresponding theories of the base structure. This fails for Muchnik's iteration.
An epidemiological study of hyperhidrosis.

BACKGROUND Hyperhidrosis affects approximately 3% of the population. The nature of those patients presenting for treatment has not been well studied, however. OBJECTIVE The objective was to perform a descriptive, multicenter study of patterns of patients referred for treatment of focal hyperhidrosis. METHODS AND MATERIALS A convenience sampling of consecutive patients referred for consideration of BTX-A therapy was surveyed. RESULTS A total of 508 patient records (266 patients from Canada; 242 from the United States) were reviewed; 62.8% of those patients were female. The most common presentation was axillary hyperhidrosis in 73.0% of patients. Most of the patients were moderately to severely affected by their hyperhidrosis, with Hyperhidrosis Disease Severity Scale scores of 3 or 4. There were trends found of facial and scalp hyperhidrosis affecting more men than women and being triggered by food much more frequently than in other sites of hyperhidrosis. CONCLUSION This study has demonstrated novel findings, especially in the differing presentations of hyperhidrosis between men and women.
CXCL12α/SDF‐1 from perisynaptic Schwann cells promotes regeneration of injured motor axon terminals

The neuromuscular junction has retained through evolution the capacity to regenerate after damage, but little is known on the inter‐cellular signals involved in its functional recovery from trauma, autoimmune attacks, or neurotoxins. We report here that CXCL12α, also abbreviated as stromal‐derived factor‐1 (SDF‐1), is produced specifically by perisynaptic Schwann cells following motor axon terminal degeneration induced by α‐latrotoxin. CXCL12α acts via binding to the neuronal CXCR4 receptor. A CXCL12α‐neutralizing antibody or a specific CXCR4 inhibitor strongly delays recovery from motor neuron degeneration in vivo. Recombinant CXCL12α in vivo accelerates neurotransmission rescue upon damage and very effectively stimulates the axon growth of spinal cord motor neurons in vitro. These findings indicate that the CXCL12α‐CXCR4 axis plays an important role in the regeneration of the neuromuscular junction after motor axon injury. The present results have important implications in the effort to find therapeutics and protocols to improve recovery of function after different forms of motor axon terminal damage.
A Knowledge-Based Perspective for Software Process Modeling

As the acquisition and sharing of knowledge form the backbone of the software development process, it is important to identify knowledge discrepancies between the process elements. Explicit representation of the knowledge components within a software process model can provide a means to expose these discrepancies. This paper presents an extension of the Software and System Process Engineering Metamodel (SPEM), to be used as a new knowledge modeling layer. The approach, which is based on ontologies for knowledge representation, constitutes an explicit method for representing knowledge within process models. A concept matching indicator shows the state of the process model in terms of the concept gaps for each task within the process. This indicator could lead to more informed decision making and better management of the associated risks, in terms of team competency, documentation quality, and the training required to mitigate them.
A survey on signals and systems in ambulatory blood pressure monitoring using pulse transit time

Blood pressure monitoring based on pulse transit or arrival time has been the focus of much research in order to design ambulatory blood pressure monitors. The accuracy of these monitors is limited by several challenges, such as acquisition and processing of physiological signals as well as changes in vascular tone and the pre-ejection period. In this work, a literature survey covering recent developments is presented in order to identify gaps in the literature. The findings of the literature are classified according to three aspects. These are the calibration of pulse transit/arrival times to blood pressure, acquisition and processing of physiological signals and finally, the design of fully integrated blood pressure measurement systems. Alternative technologies as well as locations for the measurement of the pulse wave signal should be investigated in order to improve the accuracy during calibration. Furthermore, the integration and validation of monitoring systems needs to be improved in current ambulatory blood pressure monitors.
Ageing reduces nitric‐oxide‐ and prostaglandin‐mediated vasodilatation in exercising humans

In older humans, infusions of endothelial agonists suggest endothelial dysfunction, due in part to less nitric oxide (NO)‐ and prostaglandin (PG)‐mediated vasodilatation, and a shift toward PG‐mediated vasoconstriction. Ageing can also be associated with lower exercise blood flow (exercise hyperaemia), but the vascular mechanisms mediating this remain unknown. Notably, in young adults, inhibition of NO and PGs during exercise decreases exercise hyperaemia by ∼20 and ∼12%, respectively. We tested our first hypothesis that in older humans inhibition of NO would decrease hyperaemia, but that inhibition of PGs would increase hyperaemia by blocking vasoconstrictor PGs. Fifteen older subjects (65 ± 3 years) performed dynamic forearm exercise for 20 min (20 contractions min−1). Forearm blood flow (FBF) was measured beat‐to‐beat with Doppler ultrasound, while saline or drugs were infused sequentially via brachial artery catheter in the exercising forearm. After achieving steady‐state exercise, l‐NAME (25 mg) was infused over 5 min to inhibit NO synthase. After a further 2 min of exercise (saline), ketorolac (6 mg) was infused over 5 min to inhibit PGs, followed by a futher 3 min of exercise with saline. Drug order was reversed in seven subjects. l‐NAME reduced steady‐state exercise hyperaemia by 12 ± 3% in older subjects (P < 0.01), whereas ketorolac had no net effect on blood flow (3 ± 6%, P > 0.4). The effects of l‐NAME and ketorolac were independent of drug order. By comparing these results with our previous results in young adults, we tested our second hypothesis that in older humans inhibition of NO or PGs would have less impact on exercise hyperaemia due to less vasodilatation from these signals. Our results suggest that, compared with young adults, in older humans the relative contribution of NO to exercise hyperaemia is reduced ∼45% (22 ± 4 versus 12 ± 3%), but the role of PG in mediating vasodilatation is lost in ageing human skeletal muscle. Lower exercise hyperaemia in older humans may be mediated in part by less NO‐ and PG‐mediated vasodilatation during exercise.
Stock Market Expectations of Dutch Households

Despite its importance for the analysis of life-cycle behavior and, in particular, retirement planning, stock ownership by private households is poorly understood. Among other approaches to investigate this puzzle, recent research has started to elicit private households' expectations of stock market returns. This paper reports findings from a study that collected data over a two-year period both on households' stock market expectations (subjective probabilities of gains or losses) and on whether they own stocks. We document substantial heterogeneity in financial market expectations. Expectations are correlated with stock ownership. Over the two years of our data, stock market prices increased, and expectations of future stock market price changes also increased, lending support to the view that expectations are influenced by recent stock gains or losses.
Energy-Efficient Opportunistic Routing in Wireless Sensor Networks

Opportunistic routing, has been shown to improve the network throughput, by allowing nodes that overhear the transmission and closer to the destination to participate in forwarding packets, i.e., in forwarder list. The nodes in forwarder list are prioritized and the lower priority forwarder will discard the packet if the packet has been forwarded by a higher priority forwarder. One challenging problem is to select and prioritize forwarder list such that a certain network performance is optimized. In this paper, we focus on selecting and prioritizing forwarder list to minimize energy consumption by all nodes. We study both cases where the transmission power of each node is fixed or dynamically adjustable. We present an energy-efficient opportunistic routing strategy, denoted as EEOR. Our extensive simulations in TOSSIM show that our protocol EEOR performs better than the well-known ExOR protocol (when adapted in sensor networks) in terms of the energy consumption, the packet loss ratio, and the average delivery delay.
Goal-setting to Promote a Healthier Lifestyle in Later Life: Qualitative Evaluation of the AgeWell Trial

ABSTRACT Objective: We report a mixed method evaluation of the feasibility and implementation of the AgeWell goal-setting intervention to promote healthy ageing later life. Method: Researcher field notes, goal-setting interview content, and semi-structured interviews with participants were content analysed to review trial implementation and participants’ perspective on the goal-setting and mentoring intervention. Results: 75 people were recruited: 21 in the goal-setting and 22 in the goal-setting with mentoring arms of the intervention. Goal-setting was feasible in the main domains of interest. Adherence to the protocol was good and the mentoring schedule was adhered to. Participants reported satisfaction with their goal attainment, but barriers for non-achievement were also identified. Recommendations for small changes to the intervention included reducing the number of goals. Conclusions: Participants understood the goal-setting process, and were able to set realistic and achievable lifestyle goals. The intervention and the procedures were acceptable but changes in how goal-setting is both introduced and monitored are needed for wider implementation. Clinical Implications: Goal-setting can be a useful process to help people alter their lifestyle to allow them to age more successfully and reduce risk factors associated with dementia.
Facultative Symbiont Infections Affect Aphid Reproduction

Some bacterial symbionts alter their hosts reproduction through various mechanisms that enhance their transmission in the host population. In addition to its obligatory symbiont Buchnera aphidicola, the pea aphid Acyrthosiphon pisum harbors several facultative symbionts influencing several aspects of host ecology. Aphids reproduce by cyclical parthenogenesis whereby clonal and sexual reproduction alternate within the annual life cycle. Many species, including the pea aphid, also show variation in their reproductive mode at the population level, with some lineages reproducing by cyclical parthenogenesis and others by permanent parthenogenesis. While the role of facultative symbionts has been well studied during the parthenogenetic phase of their aphid hosts, very little is known on their possible influence during the sexual phase. Here we investigated whether facultative symbionts modulate the capacity to produce sexual forms in various genetic backgrounds of the pea aphid with controlled symbiont composition and also in different aphid genotypes from natural populations with previously characterized infection status and reproductive mode. We found that most facultative symbionts exhibited detrimental effects on their hosts fitness under sex-inducing conditions in comparison with the reference lines. We also showed that the loss of sexual phase in permanently parthenogenetic lineages of A. pisum was not explained by facultative symbionts. Finally, we demonstrated that Spiroplasma infection annihilated the production of males in the host progeny by inducing a male-killing phenotype, an unexpected result for organisms such as aphids that reproduce primarily through clonal reproduction.
Reproductive Biology and Endocrinology Spatio-temporal Expression Patterns of Anandamide-binding Receptors in Rat Implantation Sites: Evidence for a Role of the Endocannabinoid System during the Period of Placental Development

Background: Although there is growing evidence that endocannabinoids play a critical role in early pregnancy, there are no studies describing the possible targets for this system after implantation. The endometrial stroma, which undergoes extensive proliferation and differentiation giving rise to the decidua and the trophoblast cells that invade after the initial stages of implantation, are potential targets. Since high anandamide (AEA) levels, the main endocannabinoid, are detrimental to implantation and in order to gain insight into the role of the endocannabinoid system in the development of the fetoplacental unit, the spatio-temporal pattern of expression of the anandamide-binding receptors, CB1, CB2 and the vanilloid receptor (TRPV1), were investigated by quantitative RT-PCR, western blot and immunohistochemistry.