Miracle-dz/UniFAR-FTUs huggingface dataset:
Chaotic Frequency Scaling in a Coupled Oscillator Model for Free Rhythmic Actions

The question of how best to model rhythmic movements at self-selected amplitude-frequency combinations, and their variability, is a long-standing issue. This study presents a systematic analysis of a coupled oscillator system that has successfully accounted for the experimental result that humans' preferred oscillation frequencies closely correspond to the linear resonance frequencies of the biomechanical limb systems, a phenomenon known as resonance tuning or frequency scaling. The dynamics of the coupled oscillator model is explored by numerical integration in different areas of its parameter space, where a period doubling route to chaotic dynamics is discovered. It is shown that even in the regions of the parameter space with chaotic solutions, the model still effectively scales to the biomechanical oscillator's natural frequency. Hence, there is a solution providing for frequency scaling in the presence of chaotic variability. The implications of these results for interpreting variability as fundamentally stochastic or chaotic are discussed.
A novel physical carrier sensing scheme for enhancing spatial reuse in multihop wireless networks

Recently, tuning the physical carrier sensing threshold (CSth) has been proposed as an efficient mechanism to enhance the network throughput in an IEEE 802.11-based multihop ad hoc networks. The physical carrier sensing method reduces the likelihood of collision by preventing nodes in the vicinity of each other from transmitting simultaneously, while allowing nodes that are separated by a safe margin to engage in concurrent transmission. In this paper, we propose a distributed adaptive scheme through which nodes dynamically adjust their CSth to eliminate the likelihood of collisions from hidden terminals and in turn enhances spatial reuse by reducing the number of exposed terminals. Specifically, a node adjusts its CSth based on both its success/ failure history attempts and the information it receives from neighboring nodes through CTS packets. Moreover, to reduce the effect of exposed terminals, the proposed scheme employs the RTS/CTS exchange only for the purpose of informing neighboring nodes of their CSth but not to silence them. The proposed scheme adaptively performs a dynamic switch between the RTS/CTS access scheme and the basic scheme based on a predefined policy in order to avoid the additional overhead caused by the RTS/CTS exchange. Simulations results have demonstrated the significant throughput gains that can be achieved by the proposed scheme, compared with other methods in recent literature.
The Role of Foreign Currency Debt in Financial Crises: 1880-1913 vs. 1972-1997

We show that exposure to foreign currency debt does not necessarily increase the risk of having a financial crisis. Some countries do not suffer from financial fragility despite original sin. Before 1913 British offshoots and Scandinavia afflicted with it avoided financial meltdowns. Today many advanced countries have original sin but few have had crises. In both periods, aggregate balance sheet mismatches are associated with a greater likelihood of a crisis. The evidence suggests that foreign currency debt is dangerous when mis-managed. This is part of the difference between developed countries and emerging markets both of which borrow in foreign currency.
Non-stop Haskell

We describe an efficient technique for incorporating Baker's incremental garbage collection algorithm into the Spineless Tagless G-machine on stock hardware. This algorithm eliminates the stop/go execution associated with bulk copying collection algorithms, allowing the system to place an upper bound on the pauses due to garbage collection. The technique exploits the fact that objects are always accessed by jumping to code rather than being explicitly dereferenced. It works by modifying the entry code-pointer when an object is in the transient state of being evacuated but not scavenged. An attempt to enter it from the mutator causes the object to "self-scavenge" transparently before resetting its entry code pointer. We describe an implementation of the scheme in v4.01 of the Glasgow Haskell Compiler and report performance results obtained by executing a range of applications. These experiments show that the read barrier can be implemented in dynamic dispatching systems such as the STG-machine with very short mutator pause times and with negligible overhead on execution time.
Fast Tac Metabolizers at Risk—It is Time for a C/D Ratio Calculation

Tacrolimus (Tac) is a part of the standard immunosuppressive regimen after renal transplantation (RTx). However, its metabolism rate is highly variable. A fast Tac metabolism rate, defined by the Tac blood trough concentration (C) divided by the daily dose (D), is associated with inferior renal function after RTx. Therefore, we hypothesize that the Tac metabolism rate impacts patient and graft survival after RTx. We analyzed all patients who received a RTx between January 2007 and December 2012 and were initially treated with an immunosuppressive regimen containing Tac (Prograf®), mycophenolate mofetil, prednisolone and induction therapy. Patients with a Tac C/D ratio <1.05 ng/mL × 1/mg at three months after RTx were characterized as fast metabolizers and those with a C/D ratio ≥1.05 ng/mL × 1/mg as slow metabolizers. Five-year patient and overall graft survival were noticeably reduced in fast metabolizers. Further, fast metabolizers showed a faster decline of eGFR (estimated glomerular filtration rate) within five years after RTx and a higher rejection rate compared to slow metabolizers. Calculation of the Tac C/D ratio three months after RTx may assist physicians in their daily clinical routine to identify Tac-treated patients at risk for the development of inferior graft function, acute rejections, or even higher mortality.
Potential of human induced pluripotent stem cells in studies of liver disease

Liver disease is a leading cause of death in the Western world. However, our insight into the underlying disease mechanisms and the development of novel therapeutic agents has been hindered by limited availability of primary tissue, intraspecies variability associated with the use of animal models, and reduced long‐term viability of isolated and diseased liver cells. The emergence of human induced pluripotent stem cells and differentiation protocols to generate hepatocyte‐like cells has opened the possibility of addressing these issues. Here, we discuss the recent progress and potential in the production of various cell types constituting the liver and their applications to model liver diseases and test drug toxicity in vitro. (Hepatology 2015;62:303‐311)
Extension and Validation of an Adult Gaming Addiction Scale

Video game addiction among adults is a serious mental health issue. Unfortunately, research on video game addiction is in its infancy and impeded by the lack of a valid and reliable measure for use with adults. Lemmens, Valkenburg, and Peter (2009) developed an adolescent video game addiction measure, the Gaming Addiction Scale (GAS); however, it has not been validated for use with an adult population. The primary aim of this study was to evaluate the appropriateness of the GAS for use with adults and evaluate whether the measure is a valid and reliable measure of adult video game addiction. The measure was administered to a population of 2,820 massively multiplayer online adult gamers through popular gaming websites. Factor analysis was conducted to evaluate whether the items sorted into the same seven underlying criteria (i.e., salience, tolerance, mood modification, relapse, withdrawal, conflict, and problems) of video game addiction as the original study. This analysis revealed a four-factor structure that differed from the adolescent version of the measure but still encompassed the seven criteria of gaming addiction in a coherent manner. The GAS exhibited strong reliability and concurrent validity with loneliness, life satisfaction, and time spent gaming. The GAS did not exhibit discriminant validity with a measure of social anxiety. A hypothesized moderating effect of time spent gaming on the relationship between video game addiction and playing with real-life friends was not supported. The GAS is reliable and compatible with current understandings and diagnostic criteria; it has potential as a useful measure of video game addiction for adults. Future research should focus on further validation of the measure for adults, and clarifying the relationship between social anxiety and gaming addiction.
Influence of Ohmic Heating on Advection-dominated Accretion Flows

Advection-dominated, high-temperature, quasi-spherical accretion flow onto a compact object, recently considered by a number of authors, assumes that the dissipation of turbulent energy of the flow heats the ions and that the dissipated energy is advected inward. It is suggested that the efficiency of conversion of accretion energy to radiation can be very much smaller than unity. However, it is likely that the flows have an equipartition magnetic field with the result that dissipation of magnetic energy at a rate comparable to that for the turbulence must occur by ohmic heating. We argue that this heating occurs as a result of plasma instabilities and that the relevant instabilities are current driven in response to the strong electric fields parallel to the magnetic field. We argue further that these instabilities heat predominantly the electrons. We conclude that the efficiency of conversion of accretion energy to radiation can be much smaller than unity only for the unlikely condition that the ohmic heating of the electrons is negligible.
Bone morphogenetic protein‐6 is a neurotrophic factor for calbindin‐positive striatal neurons

Bone morphogenetic proteins (BMPs) are a set of members of the transforming growth factor‐β superfamily recently described as promoting the differentiation of several neuronal populations within the basal ganglia. This study examined whether a member of this family, BMP‐6, could exert neurotrophic effects on the neurons of the striatum, in which BMP‐6 mRNA had been previously detected during development. Here we show that BMP‐6 increases the number and differentiation of calbindin‐positive neurons in vitro. Indeed, BMP‐6 increased the total area, the perimeter, and the degree of arborization of this neuronal population. This trophic factor promoted dendritic growth without modifying axonal length or soma area. Furthermore, BMP‐6 increased the number of glial fibrillary acidic protein‐positive cells while decreasing the number of nestin‐positive cells. The suppression of cell proliferation or glial development by the antimitotic fluorodeoxyuridine removed the effects on striatal neurons, suggesting the involvement of astroglial cells in the differentiation induced by BMP‐6. The current results confirm the relevance of BMPs in the development of the striatum and emphasize the crucial importance of the trophic interaction between glial and neuronal cells. © 2002 Wiley‐Liss, Inc.
Brain Metabolism during Hallucination-Like Auditory Stimulation in Schizophrenia

Auditory verbal hallucinations (AVH) in schizophrenia are typically characterized by rich emotional content. Despite the prominent role of emotion in regulating normal perception, the neural interface between emotion-processing regions such as the amygdala and auditory regions involved in perception remains relatively unexplored in AVH. Here, we studied brain metabolism using FDG-PET in 9 remitted patients with schizophrenia that previously reported severe AVH during an acute psychotic episode and 8 matched healthy controls. Participants were scanned twice: (1) at rest and (2) during the perception of aversive auditory stimuli mimicking the content of AVH. Compared to controls, remitted patients showed an exaggerated response to the AVH-like stimuli in limbic and paralimbic regions, including the left amygdala. Furthermore, patients displayed abnormally strong connections between the amygdala and auditory regions of the cortex and thalamus, along with abnormally weak connections between the amygdala and medial prefrontal cortex. These results suggest that abnormal modulation of the auditory cortex by limbic-thalamic structures might be involved in the pathophysiology of AVH and may potentially account for the emotional features that characterize hallucinatory percepts in schizophrenia.
Spinal Fusion in the Next Generation: Gene and Cell Therapy Approaches

Bone fusion represents a challenge in the orthopedics practice, being especially indicated for spine disorders. Spinal fusion can be defined as the bony union between two vertebral bodies obtained through the surgical introduction of an osteoconductive, osteoinductive, and osteogenic compound. Autogenous bone graft provides all these three qualities and is considered the gold standard. However, a high morbidity is associated with the harvest procedure. Intensive research efforts have been spent during the last decades to develop new approaches and technologies for successful spine fusion. In recent years, cell and gene therapies have attracted great interest from the scientific community. The improved knowledge of both mesenchymal stem cell biology and osteogenic molecules allowed their use in regenerative medicine, representing attractive approaches to achieve bone regeneration also in spinal surgery applications. In this review we aim to describe the developing gene- and cell-based bone regenerative approaches as promising future trends in spine fusion.
G9a Histone Methyltransferase Contributes to Imprinting in the Mouse Placenta

ABSTRACT Whereas DNA methylation is essential for genomic imprinting, the importance of histone methylation in the allelic expression of imprinted genes is unclear. Imprinting control regions (ICRs), however, are marked by histone H3-K9 methylation on their DNA-methylated allele. In the placenta, the paternal silencing along the Kcnq1 domain on distal chromosome 7 also correlates with the presence of H3-K9 methylation, but imprinted repression at these genes is maintained independently of DNA methylation. To explore which histone methyltransferase (HMT) could mediate the allelic H3-K9 methylation on distal chromosome 7, and at ICRs, we generated mouse conceptuses deficient for the SET domain protein G9a. We found that in the embryo and placenta, the differential DNA methylation at ICRs and imprinted genes is maintained in the absence of G9a. Accordingly, in embryos, imprinted gene expression was unchanged at the domains analyzed, in spite of a global loss of H3-K9 dimethylation (H3K9me2). In contrast, the placenta-specific imprinting of genes on distal chromosome 7 is impaired in the absence of G9a, and this correlates with reduced levels of H3K9me2 and H3K9me3. These findings provide the first evidence for the involvement of an HMT and suggest that histone methylation contributes to imprinted gene repression in the trophoblast.
Effects of age on energy expenditure and substrate oxidation during experimental overfeeding in healthy men.

Relatively little is known about the influence of age on energy regulation during energy imbalance. We compared the effects of overfeeding on changes in energy expenditure, substrate oxidation, and energy deposition between young men (age 23.7 +/- 1.1 [SEM] years) and older men (age 70.0 +/- 7.0) of normal body weight who were leading unrestricted lives. Changes in total energy expenditure, resting energy expenditure (REE), the thermic effect of feeding (TEF), respiratory quotient (RQ), and body energy content were determined in response to overeating by 4.09 +/- 0.07 Megajoule (MJ)/day for 21 days in 16 healthy subjects consuming a typical diet. After excluding data from one young subject with unusual results and adjusting for individual differences in excess energy intake, there was a tendency towards a smaller increase in REE in older men compared to the young men (p = .07) which was accounted for by their lower fat-free mass (p = .016). There was also a significantly smaller increase in resting energy expenditure averaged over fasting and fed states (i.e, REE + TEF) with overfeeding in older men than in young men (p < .01). Combined, these smaller increases in energy expenditure with overfeeding in the older subjects averaged an estimated 365 kilojoule (kJ)/day (8.9% of the excess energy intake) (p < .02). There were also significant effects of age on fasting RQ (p < .001) and the change in RQ with overfeeding (p < .001), but no significant increase in energy expenditure for physical activity and thermoregulation with overfeeding in either age-group. These results are consistent with the suggestion that older individuals experience both a reduction in the ability to increase energy expenditure, and an alteration in the pattern of substrate utilization, in response to overfeeding. These changes may promote cumulative increases in body energy during normal cycles of positive energy balance unless compensated for by adaptive variations in energy intake.
Mothers Speak Less Clearly to Infants Than to Adults: A Comprehensive Test of the Hyperarticulation Hypothesis

Infants learn language at an incredible speed, and one of the first steps in this voyage is learning the basic sound units of their native languages. It is widely thought that caregivers facilitate this task by hyperarticulating when speaking to their infants. Using state-of-the-art speech technology, we addressed this key theoretical question: Are sound categories clearer in infant-directed speech than in adult-directed speech? A comprehensive examination of sound contrasts in a large corpus of recorded, spontaneous Japanese speech demonstrates that there is a small but significant tendency for contrasts in infant-directed speech to be less clear than those in adult-directed speech. This finding runs contrary to the idea that caregivers actively enhance phonetic categories in infant-directed speech. These results suggest that to be plausible, theories of infants’ language acquisition must posit an ability to learn from noisy data.
Clinical significance of subcutaneous calcinosis in patients with systemic sclerosis. Does diltiazem induce its regression?

OBJECTIVE To establish whether diltiazem reduces subcutaneous calcinosis (SCC) in patients with systemic sclerosis (SSc), and whether this calcinosis is related to other signs or symptoms. METHODS 47 patients with SSc were evaluated and divided into two groups according to the presence or absence of SCC. RESULTS Among the 12 patients with SCC who were treated with diltiazem and had sequential hand radiographs (differential time between the two radiographs: 7.8±4 years), there was a slight radiological improvement in three patients only. More patients with SCC had anticentromere antibodies than patients without (p=0.003), fewer had anti-Scl 70 antibodies (p=0.01), more had telangiectasia and giant capillaries (p=0.04 and 0.048 respectively), and SCC patients had significantly fewer capillaries at the nailfold (p=0.03). CONCLUSION These results do not clearly indicate that diltiazem is effective in calcinosis associated with SSc. Among the patients with SSc, those who also had SCC exhibited a distinctive autoimmune profile and more severe cutaneous capillary injury than those without SCC.
Improving Localization Accuracy Using Selective 3-Anchor DV-Hop Algorithm

Localization is a fundamental issue which is studied for many wireless networks applications like robotic networks. However, the existing range-free indoor localization algorithms haven't provided sufficient accuracy. In this paper, we propose a Selective 3- Anchor DV-hop algorithm with the following idea: the normal node first selects any three anchors to form a 3-anchor group, then it calculates the candidate positions based on each 3-anchor group, and finally according to the relation between candidate positions and the minimum hop counts to anchors, the normal node chooses the best candidate position. Simulation results show that our new algorithm achieves a better precision, compared with the existing relative algorithms.
Grammatical Gender and Number Agreement in Spanish: An ERP Comparison

The role of grammatical gender and number representations in syntactic processes during reading in Spanish was studied using the event-related potentials (ERPs) technique. The electroencephalogram was recorded with a dense array of 128 electrodes while Spanish speakers read word pairs (Experiment 1) or sentences (Experiment 2) in which gender or number agreement relationships were manipulated. Disagreement in word pairs formed by a noun and an adjective (e.g., faroalto [lighthousehigh]) produced an N400-type effect, while word pairs formed by an article and a noun (e.g., elpiano [the-piano]) showed an additional left anterior negativity effect (LAN). Agreement violations with the same words inserted in sentences (e.g., El piano estaba viejo y desafinado [the m-s piano m-s was old m-s and off-key]) resulted in a pattern of LANP600. This effect was found both when the violation occurred in the middle of the sentence (at the adjective), as well as when this happened at the beginning of the sentence (at the noun), but the last segment of the P600 effect was greater for the middle sentence position, which could indicate differences in the complexity of reanalysis processes. Differences between grammatical gender and number disagreement were found in late measures. In the word pairs experiment, P3 peak latency varied across conditions, being later for gender than for number disagreement. Similarly, in the sentence experiment, the last segment of the P600 effect was greater for gender than for number violations. These event-related potentials (ERPs) effects lend support to the idea that reanalysis or repair processes after grammatical disagreement detection could involve more steps in the case of gender disagreement, as grammatical gender is a feature of the lexical representation in contrast to number, which is considered a morphological feature that combines with the stem of the word.
Phenotypic discordance in a pair of monozygotic twins with Huntington’s disease

To the Editor: Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder characterized by involuntary movements, cognitive deterioration and behavioral changes. Reports of monozygotic (MZ) twins with HD are rare, with phenotypic concordance being the rule (1). Significant phenotypic discordance is very rare (2). We present a pair of MZ twins with HD who showed considerable differences in the age at onset as well as in the clinical picture.