Miracle-dz/UniFAR-FTUs huggingface dataset:
The role of plasticity-related functional reorganization in the explanation of central dyslexias

This investigation explored the hypothesis that patterns of acquired dyslexia may reflect, in part, plasticity-driven relearning that dynamically alters the division of labour (DOL) between the direct, orthography → phonology (O → P) pathway and the semantically mediated, orthography → semantics → phonology (O → S → P) pathway. Three simulations were conducted using a variant of the triangle model of reading. The model demonstrated core characteristics of normal reading behaviour in its undamaged state. When damage was followed by reoptimization (mimicking spontaneous recovery), the model reproduced the deficits observed in the central dyslexias—acute phonological damage combined with recovery matched data taken from a series of 12 phonological dyslexic patients—whilst progressive semantic damage interspersed with recovery reproduced data taken from 100 observations of semantic dementia patients. The severely phonologically damaged model also produced symptoms of deep dyslexia (imageability effects, production of semantic and mixed semantic/visual errors). In all cases, the DOL changed significantly in the recovery period, suggesting that postmorbid functional reorganization is important in understanding behaviour in chronic-stage patients.
How can authorities support urban consolidation centres? A review of the accompanying measures

Freight transport affects urban welfare primarily through congestion and emissions. An urban consolidation centre is regarded as a solution that can reduce those negative impacts of freight vehicles on the city. However, previous experience has demonstrated the challenge that these centres face in being self-sustaining. Given their positive effects on the city, authorities have supported these logistics schemes with different types of accompanying measures. In order to bring to practitioners an overview of these measures, the paper presents the results of a literature review where the different measures are classified according to their financial support, their regulatory support and their indirect regulatory support.
Knowledge and Oral Health Attitudes among Parents of Children with Congenital Heart Disease

ABSTRACT Congenital heart disease (CHD) is a devastating complex of diseases resulting from defects of development. It affects more than 1 of every 100 live births. Early preventive dental care should be adjusted to the special needs of these children in their first years of life. Knowledge of parental attitudes and experiences of dental care are therefore important. Aim : This study was done to assess the knowledge and attitudes among parents of children with congenital heart disease towards oral health and dental care. Materials and methods : Parents (n = 105) of children with congenital heart disease of an age ranging from 0 to 16 years were included in the study. A questionnaire was used to assess the knowledge and oral health attitudes. Results : The parents’ knowledge was fair but the oral health attitudes were not very satisfactory. The parents in this study also recognized the importance of oral health for the well-being of rest of the body. Conclusion : The results of this study indicate that parents’ and children’s attitudes toward oral health and dental care need to be improved.
The Chisholm firestorm: observed microstructure, precipitation and lightning activity of a pyro-Cb

HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés. The Chisholm firestorm: observed microstructure, precipitation and lightning activity of a pyro-Cb D. Rosenfeld, M. Fromm, J. Trentmann, G. Luderer, M. O. Andreae, R. Servranckx
International Journal of Hospitality Management Total Quality Management, Market Orientation and Hotel Performance: the Moderating Effects of External Environmental Factors Keywords: Total Quality Management Market Orientation Hotel Performance External Environmental Factors Structural Equation Mode

With the market competition of hotel industry being heated, it is critical that hotels have a breadth of resource and more flexible forms to meet the needs of a changing marketplace. In the past, the relation of total quality management (TQM), market orientation, and performance are equivocal. These mixed results may be due to some factors or not to include the environmental factors. This study adopts the Input-Processing-Output (IPO) concept model to construct all variables research model. The research surveyed samples of 588 and used Structural Equation Model and discriminate analysis for analysis and testing. The results show that TQM positively affects hotel performance. Market orientation positively affects hotel performance. Market orientation has the mediating effect between TQM and hotel performance. External environment factors truly play a moderator between TQM, market orientation and hotel performance, especially when external environment factors greater changes are going to help to build relationship with customer, to enhance hotel performance and further to gain chance of hotel's survival.
The art of navigating through hypertext

Hypertext (3), (19), (25) is becoming a popular approach to many computer applications, especially those dealing with the on-line presentation of large amounts of loosely structured information such as on-line documentation or computer-aided learning. There are still many issues concerning hypertext that remain to be resolved, however, many of which are in the user interface area. One of the major usability problems with hypertext is the user's risk of disorientation while navigating the information space. For example, our studies [23] showed that 56 percent of the readers of a document written in one of the most popular commercial hypertext systems agreed fully or partly with the statement I was often confused about ‘where I was. ’ To investigate a number of user interface options in hypertext systems we designed a prototype system in the form of a hypertext report on events at the 1987 hypertext workshop. This system was implemented on an Apple Macintosh with Hypercard as the programming system. (To get a feel for our hypertext system, the reader is encouraged to review Figures 1 to 10 which contain screen dumps of a session with the system and thus constitute a kind of printed demonstration or guided tour.) Hypertext is a very dynamic form of human-computer interaction and can only be fully appreciated in an interactive environment. However, even these figures give a much better understanding of the system than a traditional textual description could give.
Long-term costs and effects of psychotherapy in personality disorders

The objective was to address aspects of the SCEPTRE study that had been left unexplored so far and which have not yet been addressed in earlier publications. We formulated the following three research questions: 1. Are the improvements previously observed in patients with a cluster A, B, or C PD or PDNOS stable over five years of follow-up? Are there differences in the effectiveness of outpatient, day hospital, and inpatient treatments on the long-term outcome in patients with a cluster A, B, or C PD or PDNOS? 2. What are the effectiveness and cost-effectiveness of Short-Term Inpatient Psychotherapy based on Transactional Analysis (STIP-TA) in PD patients? 3. Is there an interaction between the patient’s psychological strength and the treatment’s level of destabilization with respect to outcome?
Information technology in construction: how to realise the benefits?

Advancement in the utilisation of computers has, in recent years, become a major, even dominating research and development target in the architecture, engineering and construction industry. However, in empirical investigations, no major benefits accruing from construction IT have been found. Why do the many IT applications, which when separately analysed seem so well justified, fail to produce positive impacts when the totality of the construction project is analysed? The objective of this chapter is to find the explanation for this paradox and to provide initial guidelines as to what should be done to correct the situation.
Designs for Operationalizing Collaborative Problem Solving for Automated Assessment

Collaborative problem solving is a complex skill set that draws on social and cognitive factors. The construct remains in its infancy due to lack of empirical evidence that can be drawn upon for validation. The differences and similarities between two large-scale initiatives that reflect this state of the art, in terms of underlying assumptions about the construct and approach to task development, are outlined. The goal is to clarify how definitions of the nature of the construct impact the approach to design of assessment tasks. Illustrations of two different approaches to the development of a task designed to elicit behaviors that manifest the construct are presented. The method highlights the degree to which these approaches might constrain a comprehensive assessment of the construct.
PERCEPTION AND SIGNAL TRANSDUCTION OF CYTOKININS

■ Abstract Cytokinins are plant hormones implicated in diverse and essential processes in plant growth and development, and key genes for the metabolism and actions of cytokinins have recently been identified. Cytokinins are perceived by three histidine kinases—CRE1/WOL/AHK4, AHK2, and AHK3—which initiate intracellular phosphotransfer. The final destination of the transferred phosphoryl groups is response regulators. The type-BArabidopsisresponse regulators (ARRs) are DNA-binding transcriptional activators that are required for cytokinin responses. On the other hand, the type-A ARRs act as repressors of cytokinin-activated transcription. How phosphorelay regulate response regulators and how response regulators control downstream events are open questions and discussed in this review.
Prolonged Photoresponses and Defective Adaptation in Rods of Gβ5-/- Mice

Timely deactivation of G-protein signaling is essential for the proper function of many cells, particularly neurons. Termination of the light response of retinal rods requires GTP hydrolysis by the G-protein transducin, which is catalyzed by a protein complex that includes regulator of G-protein signaling RGS9-1 and the G-protein β subunit Gβ5-L. Disruption of the Gβ5 gene in mice (Gβ5-/-) abolishes the expression of Gβ5-L in the retina and also greatly reduces the expression level of RGS9-1. We examined transduction in dark- and light-adapted rods from wild-type and Gβ5-/- mice. Responses of Gβ5-/- rods were indistinguishable in all respects from those of RGS9-/- rods. Loss of Gβ5-L (and RGS9-1) had no effect on the activation of the G-protein cascade, but profoundly slowed its deactivation and interfered with the speeding of incremental dim flashes during light adaptation. Both RGS9-/- and Gβ5-/- responses were consistent with another factor weakly regulating GTP hydrolysis by transducin in a manner proportional to the inward current. Our results indicate that a complex containing RGS9-1-Gβ5-L is essential for normal G-protein deactivation and rod function. In addition, our light adaptation studies support the notion than an additional weak GTPase-accelerating factor in rods is regulated by intracellular calcium and/or cGMP.
The new final Clinical Skills examination in human medicine in Switzerland: Essential steps of exam development, implementation and evaluation, and central insights from the perspective of the national Working Group

Objective: Since 2011, the new national final examination in human medicine has been implemented in Switzerland, with a structured clinical-practical part in the OSCE format. From the perspective of the national Working Group, the current article describes the essential steps in the development, implementation and evaluation of the Federal Licensing Examination Clinical Skills (FLE CS) as well as the applied quality assurance measures. Finally, central insights gained from the last years are presented. Methods: Based on the principles of action research, the FLE CS is in a constant state of further development. On the foundation of systematically documented experiences from previous years, in the Working Group, unresolved questions are discussed and resulting solution approaches are substantiated (planning), implemented in the examination (implementation) and subsequently evaluated (reflection). The presented results are the product of this iterative procedure. Results: The FLE CS is created by experts from all faculties and subject areas in a multistage process. The examination is administered in German and French on a decentralised basis and consists of twelve interdisciplinary stations per candidate. As important quality assurance measures, the national Review Board (content validation) and the meetings of the standardised patient trainers (standardisation) have proven worthwhile. The statistical analyses show good measurement reliability and support the construct validity of the examination. Among the central insights of the past years, it has been established that the consistent implementation of the principles of action research contributes to the successful further development of the examination. Conclusion: The centrally coordinated, collaborative-iterative process, incorporating experts from all faculties, makes a fundamental contribution to the quality of the FLE CS. The processes and insights presented here can be useful for others planning a similar undertaking.
TV Series Production and the Urban Restructuring of Istanbul

This article explores the entangled relationship between Turkish TV series and the city of Istanbul examining both the series’ representation of the city and the effects of flourishing series’ production on the city. We argue that TV series production and representation changes and is changed by the urban restructuring of globalizing Istanbul since the late 1980s. Analyzing internationally popular series such as Noor, Valley of the Wolves, and 1001 Nights and building on television, urban and cultural studies, this article explores the ways that Istanbul’s neoliberal renovation process appears in and is shaped by TV series. The three segments of the article probe how series reflect and push forth the gentrification of historical neighborhoods, their increasing use of abandoned post-industrial areas as shooting locations, and their promotion of spaces associated with creative industries and luxury lifestyles. We show that both images and image making are connected to city making.
Genome Sequence of Lactobacillus helveticus, an Organism Distinguished by Selective Gene Loss and Insertion Sequence Element Expansion

ABSTRACT Mobile genetic elements are major contributing factors to the generation of genetic diversity in prokaryotic organisms. For example, insertion sequence (IS) elements have been shown to specifically contribute to niche adaptation by promoting a variety of genetic rearrangements. The complete genome sequence of the cheese culture Lactobacillus helveticus DPC 4571 was determined and revealed significant conservation compared to three nondairy gut lactobacilli. Despite originating from significantly different environments, 65 to 75% of the genes were conserved between the commensal and dairy lactobacilli, which allowed key niche-specific gene sets to be described. However, the primary distinguishing feature was 213 IS elements in the DPC 4571 genome, 10 times more than for the other lactobacilli. Moreover, genome alignments revealed an unprecedented level of genome stability between these four Lactobacillus species, considering the number of IS elements in the L. helveticus genome. Comparative analysis also indicated that the IS elements were not the primary agents of niche adaptation for the L. helveticus genome. A clear bias toward the loss of genes reported to be important for gut colonization was observed for the cheese culture, but there was no clear evidence of IS-associated gene deletion and decay for the majority of genes lost. Furthermore, an extraordinary level of sequence diversity exists between copies of certain IS elements in the DPC 4571 genome, indicating they may represent an ancient component of the L. helveticus genome. These data suggest a special unobtrusive relationship between the DPC 4571 genome and its mobile DNA complement.
Testing model predictions of the cold dark matter cosmology for the sizes, colours, morphologies and luminosities of galaxies with the SDSS

The huge size and uniformity of the Sloan Digital Sky Survey (SDSS) make possible an exacting test of current models of galaxy formation. We compare the predictions of the galform semi-analytical galaxy formation model for the luminosities, morphologies, colours and scalelengths of local galaxies. galform models the luminosity and size of the disc and bulge components of a galaxy, and so we can compute quantities which can be compared directly with SDSS observations, such as the Petrosian magnitude and the Sersic index. We test the predictions of two published models set in the cold dark matter cosmology: the Baugh et al. model, which assumes a top-heavy initial mass function (IMF) in starbursts and superwind feedback, and the Bower et al. model, which uses active galactic nucleus feedback and a standard IMF. The Bower et al. model better reproduces the overall shape of the luminosity function, the morphology–luminosity relation and the colour bimodality observed in the SDSS data, but gives a poor match to the size–luminosity relation. The Baugh et al. model successfully predicts the size–luminosity relation for late-type galaxies. Both models fail to reproduce the sizes of bright early-type galaxies. These problems highlight the need to understand better both the role of feedback processes in determining galaxy sizes, in particular the treatment of the angular momentum of gas reheated by supernovae, and the sizes of the stellar spheroids formed by galaxy mergers and disc instabilities.
3-D FEA of hard turning: Investigation of PCBN cutting tool micro-geometry effects

In this study, 3-D finite element modeling of precision hard turning has been used to investigate the effects of cutting edge microgeometry on tool forces, temperatures and stresses in machining of AISI H13 steel using polycrystalline cubic boron nitrite (PCBN) inserts with two distinct edge preparations. Hard turning experiments were conducted to investigate the effects of cutting edge geometry, feed rate and cutting speed on tool flank wear and resultant forces. During hard turning experiments, lowgrade PCBN inserts with honed and chamfered edge preparations and through-hardened AISI H13 steel bars were used. Three components of tool forces and flank wear of the inserts were measured. PCBN inserts with honed microgeometry cutting edge resulted in lower tool flank wear in all cutting conditions. The feasibility of using finite element analysis to investigate the cutting tool micro-geometry effects in 3D hard turning is also explored.
Resveratrol Attenuates Copper-Induced Senescence by Improving Cellular Proteostasis

Copper sulfate-induced premature senescence (CuSO4-SIPS) consistently mimetized molecular mechanisms of replicative senescence, particularly at the endoplasmic reticulum proteostasis level. In fact, disruption of protein homeostasis has been associated to age-related cell/tissue dysfunction and human disorders susceptibility. Resveratrol is a polyphenolic compound with proved antiaging properties under particular conditions. In this setting, we aimed to evaluate resveratrol ability to attenuate cellular senescence induction and to unravel related molecular mechanisms. Using CuSO4-SIPS WI-38 fibroblasts, resveratrol is shown to attenuate typical senescence alterations on cell morphology, senescence-associated beta-galactosidase activity, and cell proliferation. The mechanisms implicated in this antisenescence effect seem to be independent of senescence-associated genes and proteins regulation but are reliant on cellular proteostasis improvement. In fact, resveratrol supplementation restores copper-induced increased protein content, attenuates BiP level, and reduces carbonylated and polyubiquitinated proteins by autophagy induction. Our data provide compelling evidence for the beneficial effects of resveratrol by mitigating CuSO4-SIPS stressful consequences by the modulation of protein quality control systems. These findings highlight the importance of a balanced cellular proteostasis and add further knowledge on molecular mechanisms mediating resveratrol antisenescence effects. Moreover, they contribute to identifying specific molecular targets whose modulation will prevent age-associated cell dysfunction and improve human healthspan.
Assessment of Psychological Status of Orphans in Orphanagesin Baghdad City

Objectives: To assess of psychological status of orphans in orphanages in Baghdad city. Methodology: A descriptive correlation analytical study included purposive (non-probability) sample of (50) orphan was selected for the present study. The data had been collection in 9th January 2015 to 20th February 2015.Data were collected through the use of the constructed questionnaire and the process of interviewing to orphans children. Data were analyzed through the application of descriptive statistical analysis (percentage, frequency, mean of score and S.D) and inferential data analysis (Chi-square) with (SPSS, Version 20). Results: The findings of the study indicate that most of the samples (34%) have both sever, moderate anxiety level and (32%) of the samples have mild anxiety level. There is highly significant relation in anxiety level with sociodemographic data (age, education level, loss of parents), there was significant relation in anxiety level with sociodemographic data (age at admission, financial support). The findings of the study indicate that most (48%) of the samples have mild depression, (30%) of the samples have severe depression level and (22%) have moderate depression level. There is highly significant relation in depression level with sociodemographic data (age, loss of parents), there was significant relation in anxiety level with sociodemographic data (education level). Conclusion: All orphans affected with the psychological problems in different levels and there are weak relationship between females and males in gender group with psychological problems. Recommendation: The study recommends that give an educational program to those who were responsible about the orphanage to increase their knowledge toward the psychological problems such as (anxiety, depression). A guidance towards religious and moral education specialist to reduce the conflict between the orphans and development of psychosocial problems.
Chip and package co-design for high performance mixed IC

In this paper, we propose an efficient approach to reduce the effect of the Simultaneous Switching Noise (SSN) for mixed System on Chip (SoC). In order to validate the approach, we have designed a 14-bits 100MHz pipeline ADC as an example. Finite Element Method (FEM) and Method of Moment (MoM) are chose to do the electromagnetic extraction of package and bond-wires separately. The proposed approach combines the equivalent lump model with the ADC chip to perform co-design. A RC network is designed to suppress the SSN. As a result of measurement, the SFDR of the ADC `s output can reach 84dB at an input clock of 100MHz with an input signal of 10MHz, which coincides with the expectation by this approach.