Miracle-dz/UniFAR-FTUs huggingface dataset:
Contribution of Pannexin1 to Experimental Autoimmune Encephalomyelitis

Pannexin1 (Panx1) is a plasma membrane channel permeable to relatively large molecules, such as ATP. In the central nervous system (CNS) Panx1 is found in neurons and glia and in the immune system in macrophages and T-cells. We tested the hypothesis that Panx1-mediated ATP release contributes to expression of Experimental Autoimmune Encephalomyelitis (EAE), an animal model for multiple sclerosis, using wild-type (WT) and Panx1 knockout (KO) mice. Panx1 KO mice displayed a delayed onset of clinical signs of EAE and decreased mortality compared to WT mice, but developed as severe symptoms as the surviving WT mice. Spinal cord inflammatory lesions were also reduced in Panx1 KO EAE mice during acute disease. Additionally, pharmacologic inhibition of Panx1 channels with mefloquine (MFQ) reduced severity of acute and chronic EAE when administered before or after onset of clinical signs. ATP release and YoPro uptake were significantly increased in WT mice with EAE as compared to WT non-EAE and reduced in tissues of EAE Panx1 KO mice. Interestingly, we found that the P2X7 receptor was upregulated in the chronic phase of EAE in both WT and Panx1 KO spinal cords. Such increase in receptor expression is likely to counterbalance the decrease in ATP release recorded from Panx1 KO mice and thus contribute to the development of EAE symptoms in these mice. The present study shows that a Panx1 dependent mechanism (ATP release and/or inflammasome activation) contributes to disease progression, and that inhibition of Panx1 using pharmacology or gene disruption delays and attenuates clinical signs of EAE.
HOUSEHOLD TIME ALLOCATION AND ENDOGENOUS FARM STRUCTURE: IMPLICATIONS FOR THE DESIGN OF AGRICULTURAL POLICIES

We evaluate relationships among time allocation decisions for farm operators and their spouses and endogenous farm structure. We consider two aspects of farm structure{ farm scale, represented by acreage operated and harvested, and farm scope, which is represented by an index of diversification. We are particularly interested in the role of policy expectations as a factor influencing labor decisions and farm structure. Our results indicate that farm structure and household time allocations are significantly related to one another. Operators on larger and more diversified farms tend to work less off the farm. Size may be endogenous to off-farm work decisions in that farms tend to be smaller when farmers pursue off-farm work opportunities, though the converse is true for the operators' spouses. Direct (decoupled) payments tend to be associated with less off-farm work by spouses, a smaller scale of production, and more diversification. This result has relevance to the ongoing debate over the production neutrality of decoupled payments. Coupled payments tend to be associated with more off-farm work by spouses and larger farms, thus suggesting a positive effect on farm labor.
Extrapolation methods for vector sequences

This is an expository paper that describes and compares five methods for extrapolating to the limit (or anti-limit) of a vector sequence without explicit knowledge of the sequence generator. The methods are the minimal polynomial extrapolation (MPE) studied by Cabay and Jackson, Mesina, and Skelboe; the reduced rank extrapolation (RRE) of Eddy (which we show to be equivalent to Mesina’s version of MPE); the vector and scalar versions of the epsilon algorithm (VEA, SEA) introduced by Wynn and extended by Brezinski and Gekeler; and the topological epsilon algorithm (TEA) of Brezinski. We cover the derivation and error analysis of iterated versions of the algorithms, as applied to both linear and nonlinear problems, and we show why these versions tend to converge quadratically. We also present samples from extensive numerical testing that has led us to the following conclusions: (a) TEA, in spite of its role as a theoretical link between the polynomial-type and the epsilon-type methods, has no practical appl.
MAPE-R : A RESCALED MEASURE OF ACCURACY FOR CROSS-SECTIONAL FORECASTS

Accurately measuring a population and its attributes at past, present, and future points in time has been of great interest to demographers. Within discussions of forecast accuracy, demographers have often been criticized for their inaccurate prognostications of the future. Discussions of methods and data are usually at the center of these criticisms, along with suggestions for providing an idea of forecast uncertainty. The measures used to evaluate the accuracy of forecasts also have received attention and while accuracy is not the only criteria advocated for evaluating demographic forecasts, it is generally acknowledged to be the most important. In this paper, we continue the discussion of measures of forecast accuracy by concentrating on a rescaled version of a measure that is arguably the one used most often, Mean Absolute Percent Error (MAPE). The rescaled version, MAPE-R, has not had the benefit of a major empirical test, which is the central focus of this paper. We do this by comparing 10-year population forecasts for U.S. counties to 2000 census counts. We find that the MAPE-R offers a significantly more meaningful representation of average error than MAPE in the presence of outlying errors and provide guidelines for its implementation.
Dynamic Simulation and Static Matching for Action Prediction: Evidence From Body Part Priming

Accurately predicting other people's actions may involve two processes: internal real-time simulation (dynamic updating) and matching recently perceived action images (static matching). Using a priming of body parts, this study aimed to differentiate the two processes. Specifically, participants played a motion-controlled video game with either their arms or legs. They then observed arm movements of a point-light actor, which were briefly occluded from view, followed by a static test pose. Participants judged whether this test pose depicted a coherent continuation of the previously seen action (i.e., "action prediction task"). Evidence of dynamic updating was obtained after compatible effector priming (i.e., arms), whereas incompatible effector priming (i.e., legs) indicated static matching. Together, the results support action prediction as engaging two distinct processes, dynamic simulation and static matching, and indicate that their relative contributions depend on contextual factors like compatibility of body parts involved in performed and observed action.
Please Like Me: Facebook and Public Health Communication

Facebook, the most widely used social media platform, has been adopted by public health organisations for health promotion and behaviour change campaigns and activities. However, limited information is available on the most effective and efficient use of Facebook for this purpose. This study sought to identify the features of Facebook posts that are associated with higher user engagement on Australian public health organisations’ Facebook pages. We selected 20 eligible pages through a systematic search and coded 360-days of posts for each page. Posts were coded by: post type (e.g., photo, text only etc.), communication technique employed (e.g. testimonial, informative etc.) and use of marketing elements (e.g., branding, use of mascots). A series of negative binomial regressions were used to assess associations between post characteristics and user engagement as measured by the number of likes, shares and comments. Our results showed that video posts attracted the greatest amount of user engagement, although an analysis of a subset of the data suggested this may be a reflection of the Facebook algorithm, which governs what is and is not shown in user newsfeeds and appear to preference videos over other post types. Posts that featured a positive emotional appeal or provided factual information attracted higher levels of user engagement, while conventional marketing elements, such as sponsorships and the use of persons of authority, generally discouraged user engagement, with the exception of posts that included a celebrity or sportsperson. Our results give insight into post content that maximises user engagement and begins to fill the knowledge gap on effective use of Facebook by public health organisations.
Research Paper: Predictors of Student Success in Graduate Biomedical Informatics Training: Introductory Course and Program Success

OBJECTIVE To predict student performance in an introductory graduate-level biomedical informatics course from application data. DESIGN A predictive model built through retrospective review of student records using hierarchical binary logistic regression with half of the sample held back for cross-validation. The model was also validated against student data from a similar course at a second institution. MEASUREMENTS Earning an A grade (Mastery) or a C grade (Failure) in an introductory informatics course. RESULTS The authors analyzed 129 student records at the University of Texas School of Health Information Sciences at Houston (SHIS) and 106 at Oregon Health and Science University Department of Medical Informatics and Clinical Epidemiology (DMICE). In the SHIS cross-validation sample, the Graduate Record Exam verbal score (GRE-V) correctly predicted Mastery in 69.4%. Undergraduate grade point average (UGPA) and underrepresented minority status (URMS) predicted 81.6% of Failures. At DMICE, GRE-V, UGPA, and prior graduate degree significantly correlated with Mastery. Only GRE-V was a significant independent predictor of Mastery at both institutions. There were too few URMS students and Failures at DMICE to analyze. Course Mastery strongly predicted program performance defined as final cumulative GPA at SHIS (n=19, r=0.634, r2=0.40, p=0.0036) and DMICE (n=106, r=0.603, r2=0.36, p<0.001). CONCLUSIONS The authors identified predictors of performance in an introductory informatics course including GRE-V, UGPA and URMS. Course performance was a very strong predictor of overall program performance. Findings may be useful for selecting students for admission and identifying students at risk for Failure as early as possible.
Quadratic characterization and use of output stabilizable subspaces

This note treats the problem of stabilization of linear systems by static output feedback using the concept of (C, A, B)-invariant subspaces. The work provides a new characterization of output stabilizable (C, A, B)-invariant subspaces through two coupled quadratic stabilization conditions. An equivalence is shown between the existence of a solution to this set of conditions and the possibility to stabilize the system by static output feedback. An algorithm is provided and numerical examples are reported to illustrate the approach.
The Physiologic and Behavioral Implications of Playing Active and Sedentary Video Games in a Seated and Standing Position

Previous studies have assessed physiologic response while playing video games per manufacturer instructions with participants standing during active video game play and seated during sedentary game play. It is not known whether an assigned seated or standing position affects positional preference and oxygen consumption (VO2) while gaming. The purpose of the study was to assess VO2 and preference of playing active and sedentary video games in a seated and standing position. VO2 was assessed in 25 participants during four, 20-minute conditions; resting, PlayStation 2 Madden NFL Football 2011, Nintendo Wii-Sports Boxing and Nintendo Wii Madden NFL Football 2011. Each condition was divided into two positional conditions (10 minutes seated, 10 minutes standing) and each participant indicated their positional preference after each 20-minute condition. Standing VO2 (4.4 ± 0.2 ml • kg−1 • min−1 PS2, 4.6 ± 0.1 ml • kg−1 • min−1 Wii Madden, 6.8 ± 0.3 ml • kg−1 • min−1Wii Boxing) was significantly (p ≤ 0.001) greater than seated VO2 (4.0 ± 0.1 ml • kg−1 • min−1 PS2, 4.2 ± 0.1 ml • kg−1 • min−1 Wii Madden, 6.1 ± 0.3 ml • kg−1 • min−1Wii Boxing) for each gaming condition. Participants preferred (p ≤ 0.001) to sit for all gaming conditions except Wii Boxing. Playing video games while standing increases VO2 to a greater extent than playing the same games in a seated position. Standing was only preferred for the most physiologically challenging game, Wii Boxing. Gaming position should be considered when assessing the physiologic and behavioral outcomes of playing video games.
Statistical Multiplexing of Sporadic Sources - Exact and Approximate Performance Analysis

The flexibility of fast packet switching has initiated the development of the Asynchronous Trans fer Mode (ATM) which is the transmission, multiplexing, and switching technique for the future Broadband ISDN. The dimensioning of resources and the definition of an appropriate conges tion control require careful analysis of switching and multiplexing facilities. This paper presents an exact and an approximate performance analysis of the statistical multiplexing of sporadic and constant bitrate sources based on a multi-variate Markov chain. The results confirm that the dimensioning of buffers is related to short-term characteristics described by simple queueing models (for example, M/D/l-S), and connection admission control can be mainly based on long term characteristics covered by a fluid flow approximation or a simple convolution approach.
Childhood injury after a parental cancer diagnosis

A parental cancer diagnosis is psychologically straining for the whole family. We investigated whether a parental cancer diagnosis is associated with a higher-than-expected risk of injury among children by using a Swedish nationwide register-based cohort study. Compared to children without parental cancer, children with parental cancer had a higher rate of hospital contact for injury during the first year after parental cancer diagnosis (hazard ratio [HR] = 1.27, 95% confidence interval [CI] = 1.22-1.33), especially when the parent had a comorbid psychiatric disorder after cancer diagnosis (HR = 1.41, 95% CI = 1.08-1.85). The rate increment declined during the second and third year after parental cancer diagnosis (HR = 1.10, 95% CI = 1.07-1.14) and became null afterwards (HR = 1.01, 95% CI = 0.99-1.03). Children with parental cancer also had a higher rate of repeated injuries than the other children (HR = 1.13, 95% CI = 1.12-1.15). Given the high rate of injury among children in the general population, our findings may have important public health implications. DOI: http://dx.doi. org/10.7554/eLife.08500. 001
A SERUM FACTOR IN CHRONIC HYPOCOMPLEMENTEMIC NEPHRITIS DISTINCT FROM IMMUNOGLOBULINS AND ACTIVATING THE ALTERNATE PATHWAY OF COMPLEMENT

Nephritic factor (C3NeF) has been isolated from plasma of patients with hypocomplementemic chronic glomerulonephritis (HCG) by ion exchange and molecular sieve chromatography. This material was further treated with solidified anti-Ig antiserum. The purified material failed to react with antiserum to human IgG, IgG3, Fab, Fc, and kappa and lambda chains, but retained full C3NeF activity. The nonidentity of C3NeF with IgG was further demonstrated by Ouchterlony analysis using anti-IgG and anti-C3NeF. Isolated C3NeF was found to be a protein with a sedimentation coefficient of 7S and a mol wt of 150,000 daltons, which on microzone electrophoresis and gel electrophoresis at pH 8.6 behaved as a γ-globulin. C3NeF is not a C1q precipitin and does not activate the classical complement pathway. Unlike cobra venom factor, it failed to enter into a complex with C3 proactivator (C3PA) when incubated with normal human serum (NHS) and then subjected to sucrose density gradient ultracentrifugation. The action of isolated C3NeF on C3 requires C3PA, C3PA convertase (C3PAse), and properdin (P). Similarly, C3PA conversion by C3NeF requires P, C3PAse, and C3. Total hemolytic activity was lost by incubation of 64 µg of C3NeF/1 ml NHS at 37°C for 30 min. Both C3a and C5a anaphylatoxin could be generated by C3NeF in serum previously depleted of anaphylatoxin inactivator. Anti-C3NeF was found to detect an antigen in all NHS tested. Treatment of NHS with solidified anti-C3NeF caused impairment of the alternate complement pathway. It failed to sustain lysis of glutathione-treated human erythrocytes initiated by inulin. It is conceivable that the normal serum constituent which is removed by anti-C3NeF constitutes the inactive precursor of C3NeF, and a heretofore unrecognized component of the alternate pathway.
Toward a More Efficient Implementation of Antifibrillation Pacing

We devise a methodology to determine an optimal pattern of inputs to synchronize firing patterns of cardiac cells which only requires the ability to measure action potential durations in individual cells. In numerical bidomain simulations, the resulting synchronizing inputs are shown to terminate spiral waves with a higher probability than comparable inputs that do not synchronize the cells as strongly. These results suggest that designing stimuli which promote synchronization in cardiac tissue could improve the success rate of defibrillation, and point towards novel strategies for optimizing antifibrillation pacing.
Personalized treatment in advanced ALK-positive non-small cell lung cancer: from bench to clinical practice

The discovery of anaplastic lymphoma kinase (ALK) gene rearrangements and the development of tyrosine kinase inhibitors (TKI) that target them have achieved unprecedented success in the management of patients with ALK-positive non-small cell lung cancer (NSCLC). Despite the high efficacy of crizotinib, the first oral ALK TKI approved for the treatment of ALK-positive NSCLC, almost all patients inevitably develop acquired resistance, showing disease progression in the brain or in other parenchymal sites. Second- or third-generation ALK TKIs have shown to be active in crizotinib-pretreated or crizotinib-naïve ALK-positive patients, even in those with brain metastases. In this review, the current knowledge regarding ALK-positive NSCLC, focusing on the biology of the disease and the available therapeutic options are discussed.
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 810 Mild Traumatic Brain Injury Studies on outcome and prognostic factors

Lannsjö, M. 2012. Mild Traumatic Brain Injury: Studies on outcome and prognostic factors. Acta Universitatis Upsaliensis. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 810. 43 pp. Uppsala. ISBN 978-91-554-8464-4. Objectives: To explore the prevalence and structure of self-reported disability after mild traumatic brain injury and the impact of traumatic brain pathology on such outcome. Material and methods: In study 1-3, symptoms data were collected by use of Rivermead Postconcussion Symptoms Questionnaire (RPQ) and data on global function by use of Glasgow Outcome Scale Extended (GOSE) from 2602 patients at 3 months after MTBI. RPQ data were subject to factor and Rasch-analyses Head CT data from 1262 patients were used in a prediction analysis that also included age and gender. In study 4, MRI and symptoms data were collected at 2-3 days and at 3-7 months follow-up after MTBI in 19 patients. Global function was assessed at follow-up by use of the Rivermead Head Injury Follow-Up Questionnaire (RHIFUQ) and GOSE. Results: I. Most respondents reported no remaining symptoms but 24% reported ≥3 and 10% ≥7 remaining symptoms. The factor analysis demonstrated that all symptoms are correlated but also identified subgroups of symptoms. II. Rasch-analysis of RPQ showed disordered category function, local dependency of items, poor targeting of persons to items and indications of 3 or more dimensions. There was no differential item functioning. III. Head CT pathology with no need for acute intervention was observed in 52 patients (4%) but was not associated with either frequency of remaining symptoms or global outcome at 3 months post injury. Female gender and age over 30 years were associated with less favourable outcome with respect to symptoms and GOSE. IV. Post-acute MRI indicated trauma-related pathology in one patient and followup MRI indicated loss of brain volume in 4 patients. Conclusions: A substantial proportion of patients with MTBI report remaining problems at three months after MTBI. RPQ is useful but not optimal to assess symptoms outcome after MTBI and calculation of a total sum score is not recommended. Female gender and older age are negative prognostic factors while brain pathology according to CT has no effect on self-reported outcome. Loss of brain volume after MTBI according to MRI may be a sensitive marker of traumatic brain pathology and deserves further studies.
Absence of generalised employment instability in the French and British labour markets

This paper aims to enlighten the debate around the increase of instability in contemporary labour markets. Based on the case of France and the UK, we analyse the position in the national employment system of employees, from 30 to 55 years old, concerning their job stability. National employment systems are broken down into four stability regimes created from the stability variable we generate. This variable is calculated on the basis of the ratio of tenure in current job to total time spent in the labour market. Both descriptive statistics of the stability variable and probabilities for employees to joint one regime or another, show the absence of a generalised employment instability for this “central” work force.
The Mrelation in simulations of isolated and merging disk galaxies with kinetic or thermal AGN feedback

We investigate two modes of coupling the feedback energy from a central AGN to the neighboring gas in galaxy simulations: kinetic - velocity boost, and thermal heating. We formulate kinetic feedback models for energy-driven wind (EDW) and momentum-driven wind (MDW), using two free parameters: feedback efficiencyǫf, and AGN wind velocity vw. A novel numerical algorithm is implemented in the SPH code GADGET-3, to prevent the expansion of a hole in the gas distribution around the BH. We perform simulations of isolated evolution and merger of disk galaxies, of Milky-Way mass as well as lower and higher masses. We find that in the isolated galaxy BH kinetic feedback generates intermittent bipolar jet-like gas outflows. We infer that current prescriptions for BH subgrid physics in galaxy simulations can grow the BH to observed values even in an isolated disk galaxy. The BH growth is enhanced in a galaxy merger, which consequently requires different model parameters to fit the observations than an isolated case. Comparing the [MBH σ⋆] relation obtained in our simulations with observational data, we conclude that it is possible to find parameter sets for a fit in all the models (e.g. vw = 10000 km/s and ǫf = 0.25 for BH kinetic EDW), except for the case with MDW feedback in a galaxy merger, in which the BH is always too massive. The BH thermal feedback implementation of Springel, Di Matteo & Hernquist (2005) within the multiphase star-formation model is found to have negligible impact on gas properties; and the effect claimed in all previous studies is attributed to gas depletion around the BH by the creation of an artificial hole. The BH mass accretion rate in our simulations exhibit heavy fluctuations. The star formation rate is quenched with feedback by removal of gas. The circumgalactic medium (CGM) gas at galactocentric distances (20 100)h 1 kpc are found to give the best metallicity observational diagnostic to distinguish between BH models.