Miracle-dz/UniFAR-FTUs huggingface dataset:
Touch Influences Visual Perception with a Tight Orientation-Tuning

Stimuli from different sensory modalities are thought to be processed initially in distinct unisensory brain areas prior to convergence in multisensory areas. However, signals in one modality can influence the processing of signals from other modalities and recent studies suggest this cross-modal influence may occur early on, even in ‘unisensory’ areas. Some recent psychophysical studies have shown specific cross-modal effects between touch and vision during binocular rivalry, but these cannot completely rule out a response bias. To test for genuine cross-modal integration of haptic and visual signals, we investigated whether congruent haptic input could influence visual contrast sensitivity compared to incongruent haptic input in three psychophysical experiments using a two-interval, two-alternative forced-choice method to eliminate response bias. The initial experiment demonstrated that contrast thresholds for a visual grating were lower when exploring a haptic grating that shared the same orientation compared to an orthogonal orientation. Two subsequent experiments mapped the orientation and spatial frequency tunings for the congruent haptic facilitation of vision, finding a clear orientation tuning effect but not a spatial frequency tuning. In addition to an increased contrast sensitivity for iso-oriented visual-haptic gratings, we found a significant loss of sensitivity for orthogonally oriented visual-haptic gratings. We conclude that the tactile influence on vision is a result of a tactile input to orientation-tuned visual areas.
Spontaneous origin from human embryonic stem cells of liver cells displaying conjoint meso-endodermal phenotype with hepatic functions

Understanding the identity of lineage-specific cells arising during manipulations of stem cells is necessary for developing their potential applications. For instance, replacement of crucial functions in organ failure by transplantation of suitable stem-cell-derived cells will be applicable to numerous disorders, but requires insights into the origin, function and fate of specific cell populations. We studied mechanisms by which the identity of differentiated cells arising from stem cells could be verified in the context of natural liver-specific stem cells and whether such differentiated cells could be effective for supporting the liver following cell therapy in a mouse model of drug-induced acute liver failure. By comparing the identity of naturally occurring fetal human liver stem cells, we found that cells arising in cultures of human embryonic stem cells (hESCs) recapitulated an early fetal stage of liver cells, which was characterized by conjoint meso-endoderm properties. Despite this fetal stage, hESC-derived cells could provide liver support with appropriate metabolic and ammonia-fixation functions, as well as cytoprotection, such that mice were rescued from acute liver failure. Therefore, spontaneous or induced differentiation of human embryonic stem cells along the hepatic endoderm will require transition through fetal-like stages. This offers opportunities to prospectively identify whether suitable cells have been generated through manipulation of stem cells for cell therapy and other applications.
Maternal antibodies reduce costs of an immune response during development

SUMMARY Young vertebrates are dependent primarily on innate immunity and maternally derived antibodies for immune defense. This reliance on innate immunity and the associated inflammatory response often leads to reduced growth rates after antigenic challenge. However, if offspring have maternal antibodies that recognize an antigen, these antibodies should block stimulation of the inflammatory response and reduce growth suppression. To determine whether maternal and/or offspring antigen exposure affect antibody transmission and offspring growth, female Japanese quail (Coturnix japonica) and their newly hatched chicks were immunized. Mothers were immunized with lipopolysaccharide (LPS), killed avian reovirus vaccine (AR), or were given a control, phosphate-buffered saline, injection. Within each family, one-third of offspring were immunized with LPS, one-third were immunized with AR, and one-third were given the control treatment. Maternal immunization significantly affected the specific types of antibodies that were transmitted. In general, immunization depressed offspring growth. However, offspring immunized with the same antigen as their mother exhibited elevated growth in comparison to siblings immunized with a different antigen. This suggests that the growth suppressive effects of antigen exposure during development can be partially ameliorated by the presence of maternal antibodies, but in the absence of specific maternal antibodies, offspring are dependent on more costly innate immune defenses. Together, the results suggest that the local disease environment of mothers prior to reproduction significantly affects maternal antibody transmission and these maternal antibodies may allow offspring to partially maintain growth during infection in addition to providing passive humoral immune defense.
IMP‐GMP 5′‐Nucleotidase from Rat Brain: Activation by Polyphosphates

Abstract: IMP‐GMP 5′‐nucleotidase has been purified to homogeneity from total rat brain extracts. This preparation showed a unique band (Mr 54,000 ± 1,509) in sodium dodecyl sulfate‐polyacrylamide gel electrophoresis. The enzyme presented the following properties: optimal pH value, 6.5–6.8; relative velocity measured in the presence of MgCl2, MnCl2, CoCl2, and NiCl2 (2 mM), 100, 60, 11, and <1, respectively; preferred substrates, IMP and GMP; and activation constant (Ka) found for Ap4A, Ap5A, and Ap6A, 83 ± 38, 77 ± 32, and 57 ± 12 µM, respectively. Under assay conditions where activation by Ap4A was fivefold, the activation produced by dinucleotides was as follows: Ap4G (4.0), Ap4I (2.9), Ap4X (3.3), Ap4C (0.7), Ap4U (1.1), Ap4εA (1.5), Ap4ddA (1.7), Gp4G (2.2), Ap3A (1.1), and Ap2A (1.2). Polyphosphates P18, P19, P20, and P35 were activators of the reaction with calculated Ka values of 3.5 ± 0.5, 0.9 ± 0.2, 0.6 ± 0.2, and 1.3 ± 0.5 µM, respectively. The following compounds, at 0.1 mM, were effectors of the phosphotransferase reaction producing the fold activation indicated: Ap4A (8.3), Ap5A (10.2), Ap6A (10.1), Ap4G (7.7), Ap4X (7.6), Ap4U (2.1), glycerate 2,3‐bisphosphate (3.9), and unpurified P15 (7.6). Two enzyme forms of IMP‐GMP 5′‐nucleotidase were detected when the extracts from rat tissues or from the crustacean Artemia were subjected to chromatography on a Dyematrex Green A column. The ratio of the hydrolytic activities under both peaks (peak I/peak II) was as follows: brain (1.5), heart (1.9), liver (1.6), lung (2.0), testis (3.8), and Artemia cysts (2.0).
Integrated one- and two-photon imaging platform reveals clonal expansion as a major driver of mutation load

The clonal expansion of mutant cells is hypothesized to be an important first step in cancer formation. To understand the earliest stages of tumorigenesis, a method to identify and analyze clonal expansion is needed. We have previously described transgenic Fluorescent Yellow Direct Repeat (FYDR) mice in which cells that have undergone sequence rearrangements (via homologous recombination events) express a fluorescent protein, enabling fluorescent labeling of phenotypically normal cells. Here, we develop an integrated one- and two-photon imaging platform that spans four orders of magnitude to permit rapid quantification of clonal expansion in the FYDR pancreas in situ. Results show that as mice age there is a significant increase in the number of cells within fluorescent cell clusters, indicating that pancreatic cells can clonally expand with age. Importantly, >90% of fluorescent cells in aged mice result from clonal expansion, rather than de novo sequence rearrangements at the FYDR locus. The spontaneous frequency of sequence rearrangements at the FYDR locus is on par with that of other classes of mutational events. Therefore, we conclude that clonal expansion is one of the most important mechanisms for increasing the burden of mutant cells in the mouse pancreas.
Virtual Reality and the Role of the Prefrontal Cortex in Adults and Children

In this review, the neural underpinnings of the experience of presence are outlined. Firstly, it is shown that presence is associated with activation of a distributed network, which includes the dorsal and ventral visual stream, the parietal cortex, the premotor cortex, mesial temporal areas, the brainstem and the thalamus. Secondly, the dorsolateral prefrontal cortex (DLPFC) is identified as a key node of the network as it modulates the activity of the network and the associated experience of presence. Thirdly, children lack the strong modulatory influence of the DLPFC on the network due to their unmatured frontal cortex. Fourthly, it is shown that presence-related measures are influenced by manipulating the activation in the DLPFC using transcranial direct current stimulation (tDCS) while participants are exposed to the virtual roller coaster ride. Finally, the findings are discussed in the context of current models explaining the experience of presence, the rubber hand illusion, and out-of-body experiences.
Efficient match kernel in fine-grained image categorization

In this paper, we study the problem of fine-grained image categorization, which is much more useful in real applications than basic image classification. Based on the most challenge dataset, CUB-200, we combine Efficient match kernel (EMK) with the weighted spatial pyramid to achieve state-of-art performance. Comparison with BoW, which can also be viewed as kernel matching approach, EMK digs the relations among vocabulary bases and finds a new mapping in kernel framework. By it, local features are mapped to a low dimensional feature space and average the resulting vectors to form a set level feature in EMK. It is proved that it is helpful to improve the system performance.
Can we Trust Information ?-The Case of Volunteered Geographic Information

In this paper we take a fresh look at the problem of information quality for user contributed content. We assert that the traditional quality criteria for assessing the quality of geographic information are difficult to apply to Volunteered Geographic Information. The notion of informational trust is introduced and linked to the established notion of interpersonal trust. We then propose to use informational trust and reputation as proxy measures for information quality and outline the spatial and temporal dimensions of trust that have to be considered.
Teachers' use of classroom-based management strategies : a survey of New Zealand teachers : a thesis presented in partial fulfilment of the requirements for the degree of Master of Educational Psychology, Massey University, Albany, New Zealand

Behavioural problems are a constant threat to student learning and the learner environment, namely, the classroom. Researchers have identified empirically validated classroom-based strategies to support teachers to manage/deal with problem behaviours, but there has been very little research on whether these strategies are used in New Zealand (NZ) classrooms. The purpose of this present study is to fill the gap by conducting a survey of teachers’ selfreported use of management strategies, to increase students’ learning engagement and academic outcomes, and reduce behaviour interruptions. The present study is a partial replication and extension of a cross-cultural comparative study conducted in the United States (US) and Greece by Akin-Little, Little, and Laniti (2007) to determine the extent to which teachers’ utilized research-based management strategies in their classroom. The process and methodology of the present study was similar in that it used the same questionnaire but a different sample of teachers. The replication was an opportunity to compare the US-Greek findings with the situation here in NZ. The survey questionnaire was slightly modified to cater for the New Zealand demographic, such as the racial/ethnic background of the participants and the racial/ethnic composition of the classes. Another change was made regarding the use of “corporal punishment” in the school, which was replaced with the use of “restraint,” as non-violent crisis physical restraint is used as a last resort in some NZ schools/classrooms as a safety strategy to manage acting out students’ extreme behaviour. The use of corporal punishment was banned in all NZ schools (including Early Childhood Centres) in 1990. Participants for this study comprised 53 practising teachers from a range of co-educational primary schools within the metropolitan area of Auckland. The survey questionnaire contained four sections which gathered information on teacher characteristics, classroom rules, classroom child-management systems, and teachers’ perceptions of their role as a teacher, relative to their use of classroom-based management strategies. The results
An investigation into circle dance as a medium to promote occupational well-being

Circle dance, which derives from the tradition of folk dances, is a popular form of dance and is practised worldwide. As a form of meaningful physical and leisure activity, circle dance can be explored in the context of occupational therapy principles and practices to promote health and well-being. However, to date, the synergy between circle dance, occupational therapy and well-being has yet to be explored. This research develops an understanding of the complexity and meanings attributed to circle dance and its impact on occupational well-being and considers how pedagogic practice might facilitate a sense of well-being in participants. Using a constructivist approach to grounded theory (Charmaz, 2006), thirty nine in-depth interviews with participants, teachers and coordinators of teacher training programmes from the circle dance network in the United Kingdom (U.K.) were undertaken. The process of simultaneous data collection and analysis culminated in the development of three major categories, representing the meanings and experiences of circle dance participants, teachers and training coordinators. From the intersection of the three major categories, a core category was generated and named by an in-vivo code “There is a place for everybody”. The findings of this study suggest that engagement in circle dance creates meaning and can influence people’s health and well-being; they also highlight the important role that pedagogical practice plays in enriching the experience of the participants and in sustaining occupational engagement and continued involvement. This investigation provides a detailed knowledge of the process of being engaged in circle dance, whilst informing occupational therapy practice and advancing occupation-based knowledge in the field of leisure, physical activity and wellbeing. It also makes a unique contribution in relation to the pedagogy of circle dance and informs teachers from within the U.K. network offering a comprehensive understanding of the benefits of circle dance.
The Role of Peristriate Cortex in Visually Guided Behavior in the Rat

This Dissertation is brought to you for free and open access by the Theses and Dissertations at Loyola eCommons. It has been accepted for inclusion in Dissertations by an authorized administrator of Loyola eCommons. For more information, please contact ecommons@luc.edu. Acknowledgements I would like to take this opportunity to express my gratitude to several people who, through their encouragement for clear thinking and their constructive criticism for clouded thinking, made parts of my graduate education what all of it should have been: Naturally, I am grateful to the members of my doctoral dissertation committee for their time and efforts during the course of this project. Finally, I thank my wife Sandra for her patience and technical assistance which made the completion of this dis-sertation possible. '
Chaucer, Ethics, and Gender

This book makes a vigorous reassessment of the moral dimension in Chaucer's writings. For the Middle Ages, the study of human behaviour generally signified the study of the morality of attitudes, choices, and actions. Moreover, moral analysis was not gender neutral: it presupposed that certain virtues and certain failings were largely gender-specific. Alcuin Blamires - mainly concentrating on The Canterbury Tales - discloses how Chaucer adapts the composite inherited traditions of moral literature to shape the significance and the gender implications of his narratives. Chaucer, Ethics, and Gender is therefore not a theorization of ethical reading but a discussion of Chaucer's engagement with the literature of practical ethical advice. Working with the commonplace primary sources of the period, Blamires demonstrates that Stoic ideals, somewhat uncomfortably absorbed within medieval Christian moral codes as Chaucer realized, penetrate the poet's constructions of how women and men behave in matters (for instance) of friendship and anger, sexuality and chastity, protest and sufferance, generosity and greed, credulity and foresight.
Long-Term Restriction by APOBEC3F Selects Human Immunodeficiency Virus Type 1 Variants with Restored Vif Function

ABSTRACT Tandem stop mutations K26X and H27X in human immunodeficiency virus type 1 (HIV-1) vif compromise virus replication in human T-cell lines that stably express APOBEC3F (A3F) or APOBEC3G (A3G). We previously reported that partial resistance to A3G could develop in these Vif-deficient viruses through a nucleotide A200-to-T/C transversion and a vpr null mutation, but these isolates were still susceptible to restriction by A3F. Here, long-term selection experiments were done to determine how these A3G-selected isolates might evolve to spread in the presence of A3F. We found that A3F, like A3G, is capable of potent, long-term restriction that eventually selects for heritable resistance. In all 7 instances, the selected isolates had restored Vif function to cope with A3F activity. In two isolates, Vif Q26-Q27 and Y26-Q27, the resistance phenotype recapitulated in molecular clones, but when the selected vif alleles were analyzed in the context of an otherwise wild-type viral background, a different outcome emerged. Although HIV-1 clones with Vif Q26-Q27 or Y26-Q27 were fully capable of overcoming A3F, they were now susceptible to restriction by A3G. Concordant with prior studies, a lysine at position 26 proved essential for A3G neutralization. These data combine to indicate that A3F and A3G exert at least partly distinct selective pressures and that Vif function may be essential for the virus to replicate in the presence of A3F.
Use of the Phantom Electrode strategy to improve bass frequency perception for music listening in cochlear implant users

Abstract Objectives The Phantom Electrode strategy makes use of partial bipolar stimulation on the two most apical electrodes in an effort to extend the frequency range available to cochlear implant (CI) users. This study aimed to quantify the effect of the Phantom Electrode strategy on bass frequency perception in music listening in CI users. Methods Eleven adult Advanced Bionics users with the Fidelity 120 processing strategy and 16 adult normal hearing (NH) individuals participated in the study. All subjects completed the CI-multiple stimulus with hidden reference and anchor (MUSHRA), a test of an individual's ability to make discriminations in sound quality following the removal of bass frequency information. NH participants completed the CI-MUSHRA once, whereas CI users completed the task twice – once with their baseline clinical program and once with the Phantom Electrode strategy, in random order. CI users’ performance was assessed in comparison with NH performance. Results The Phantom Electrode strategy improved CI users performance on the CI-MUSHRA compared with Fidelity 120. Discussion Creation of a Phantom Electrode percept through partial bipolar stimulation of the two most apical electrodes appears to improve CI users’ perception of bass frequency information in music, contributing to greater accuracy in the ability to detect alterations in musical sound quality. Conclusion The Phantom Electrode processing strategy may enhance the experience of listening to music and thus acoustic stimuli more broadly by improving perception of bass frequencies, through direction of current towards the apical portion of the cochlea beyond the termination of the electrode.
A Bandwidth-Aware Scheduling Strategy for P2P-TV Systems

P2P-TV systems distribute live streaming contents by organizing the information flow in small chunks that are exchanged among peers. Different strategies can be implemented at the peers to select the chunk to distribute and the destination neighboring peer. Recent work showed that a good strategy consists in selecting the latest received chunk and a random neighboring peer (latest useful chunk, random peer). In this paper, leveraging on the idea that it is convenient to favor those peers that can contribute the most to the chunk distribution, we propose to select the destination peer with a probability proportional to the peer upload bandwidth. We show that the proposed scheme has a limited sensitivity to cheating peers that maliciously declare higher bandwidth than they actually have. Considering the overlay topology, we evaluate both systems in which nodes have fixed degree and systems whose overlay setup takes into account the actual peer bandwidth by assigning more neighbors to peer with higher bandwidth. We evaluate the performance in terms of delay percentiles and loss probability and evaluate the achieved improvements. Simulation results considering scenarios with up to 10,000 peers shows that the proposed schemes significantly outperform the traditional ones, so that the chunk distribution delay drops to less than 2 s from about 12 s.