Miracle-dz/UniFAR-FTUs huggingface dataset:
Long-Term Exposure to Traffic-Related Air Pollution Associated with Blood Pressure and Self-Reported Hypertension in a Danish Cohort

Background: Short-term exposure to air pollution has been associated with changes in blood pressure (BP) and emergency department visits for hypertension, but little is known about the effects of long-term exposure to traffic-related air pollution on BP and hypertension. Objectives: We studied whether long-term exposure to air pollution is associated with BP and hypertension. Methods: In 1993–1997, 57,053 participants 50–64 years of age were enrolled in a population-based cohort study. Systolic and diastolic BP (SBP and DBP, respectively) were measured at enrollment. Self-reported incident hypertension during a mean follow-up of 5.3 years was assessed by questionnaire. We used a validated dispersion model to estimate residential long-term nitrogen oxides (NOx), a marker of traffic-related air pollution, for the 1- and 5-year periods prior to enrollment and before a diagnosis of hypertension. We conducted a cross-sectional analysis of associations between air pollution and BP at enrollment with linear regression, adjusting for traffic noise, measured short-term NOx, temperature, relative humidity, and potential lifestyle confounders (n = 44,436). We analyzed incident hypertension with Cox regression, adjusting for traffic noise and potential confounders. Results: A doubling of NOx exposure during 1- and 5-year periods preceding enrollment was associated with 0.53-mmHg decreases [95% confidence interval (CI): –0.88, –0.19 mmHg] and 0.50-mmHg decreases (95% CI: –0.84, –0.16 mmHg) in SBP, respectively. Long-term exposure also was associated with a lower prevalence of baseline self-reported hypertension (per doubling of 5-year mean NOx: odds ratio = 0.96; 95% CI: 0.91, 1.00), whereas long-term NOx exposure was not associated with incident self-reported hypertension during follow-up. Conclusions: Long-term exposure to traffic-related air pollution was associated with a slightly lower prevalence of BP at baseline, but was not associated with incident hypertension.
Surface Co-Expression of Two Different PfEMP1 Antigens on Single Plasmodium falciparum-Infected Erythrocytes Facilitates Binding to ICAM1 and PECAM1

The Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) antigens play a major role in cytoadhesion of infected erythrocytes (IE), antigenic variation, and immunity to malaria. The current consensus on control of variant surface antigen expression is that only one PfEMP1 encoded by one var gene is expressed per cell at a time. We measured var mRNA transcript levels by real-time Q-PCR, analysed var gene transcripts by single-cell FISH and directly compared these with PfEMP1 antigen surface expression and cytoadhesion in three different antibody-selected P. falciparum 3D7 sub-lines using live confocal microscopy, flow cytometry and in vitro adhesion assays. We found that one selected parasite sub-line simultaneously expressed two different var genes as surface antigens, on single IE. Importantly, and of physiological relevance to adhesion and malaria pathogenesis, this parasite sub-line was found to bind both CD31/PECAM1 and CD54/ICAM1 and to adhere twice as efficiently to human endothelial cells, compared to infected cells having only one PfEMP1 variant on the surface. These new results on PfEMP1 antigen expression indicate that a re-evaluation of the molecular mechanisms involved in P. falciparum adhesion and of the accepted paradigm of absolutely mutually exclusive var gene transcription is required.
Segmented assimilation trajectories and Latino health : an analysis of the adaptation process over time

Cultural adaptation factors likely influence health status and social mobility. Using data from the Corazón Life Journey Studies, cross-sectional interviews of immigrant Latino, U.S.-born Latino, and Non-Hispanic White adults (n=272), we investigated acculturation factors, social mobility, and health outcomes across four time points, elementary school, middle school, high school and current adulthood. Using growth mixture modeling, lifetime segmented assimilation trajectories were developed describing different acculturation and social mobility changes. A four-class model best described the data. Significant differences emerged among the ethnic groups. Family Traditionalism significantly predicted acculturation’s starting point and change over time. Initial acculturation values predicted social mobility. Differences were also found in health outcomes. Findings have implications for clinical work, research and policy. Early life experiences can influence social mobility later in life, affecting individuals’ health. We encourage researchers to employ more complex models in order to reveal mechanisms underlying Latinos’ and other ethnic groups’ health inequities.
Automated 3D mapping of hippocampal atrophy and its clinical correlates in 400 subjects with Alzheimer's disease, mild cognitive impairment, and elderly controls

We used a new method we developed for automated hippocampal segmentation, called the auto context model, to analyze brain MRI scans of 400 subjects from the Alzheimer's disease neuroimaging initiative. After training the classifier on 21 hand‐labeled expert segmentations, we created binary maps of the hippocampus for three age‐ and sex‐matched groups: 100 subjects with Alzheimer's disease (AD), 200 with mild cognitive impairment (MCI) and 100 elderly controls (mean age: 75.84; SD: 6.64). Hippocampal traces were converted to parametric surface meshes and a radial atrophy mapping technique was used to compute average surface models and local statistics of atrophy. Surface‐based statistical maps visualized links between regional atrophy and diagnosis (MCI versus controls: P = 0.008; MCI versus AD: P = 0.001), mini‐mental state exam (MMSE) scores, and global and sum‐of‐boxes clinical dementia rating scores (CDR; all P < 0.0001, corrected). Right but not left hippocampal atrophy was associated with geriatric depression scores (P = 0.004, corrected); hippocampal atrophy was not associated with subsequent decline in MMSE and CDR scores, educational level, ApoE genotype, systolic or diastolic blood pressure measures, or homocysteine. We gradually reduced sample sizes and used false discovery rate curves to examine the method's power to detect associations with diagnosis and cognition in smaller samples. Forty subjects were sufficient to discriminate AD from normal and correlate atrophy with CDR scores; 104, 200, and 304 subjects, respectively, were required to correlate MMSE with atrophy, to distinguish MCI from normal, and MCI from AD. Hum Brain Mapp 2009. © 2009 Wiley‐Liss, Inc.
Economic Valuation of the Environment

The increasing demands which society places on the natural environment have led us to seek new ways of estimating the monetary costs of environmental degradation so that they can be compared with the benefits of development. This book provides a comprehensive and readable examination of the major techniques used in cost–benefit analysis and project appraisal to value environmental goods and services.
Consistency and development of prosocial dispositions: a longitudinal study.

The issue of whether there is consistency in prosocial dispositions was examined with a longitudinal data set extending from ages 4 to 5 years into early adulthood (N = 32). Spontaneous prosocial behaviors observed in the preschool classroom predicted actual prosocial behavior, other- and self-reported prosocial behavior, self-reported sympathy, and perspective taking in childhood to early adulthood. Prosocial behaviors that were not expected to reflect an other-orientation (i.e., low cost helping and compliant prosocial behavior) generally did not predict later prosocial behavior or sympathy. Sympathy appeared to partially mediate the relation of early spontaneous sharing to later prosocial dispositions. The results support the view that there are stable individual differences in prosocial responding that have their origins in early childhood.
Determinants of girls' performance in science, mathematics and technology subjects in public secondary schools in Kenya

There has been incessant low academic performance in Science, Mathematics and Technology (SMT) subjects especially among girls at form four level in Kitui Central District over the years. The aim of this study was to investigate the determinants of girls’ performance in SMT subjects in public secondary schools. Using ex-post-facto survey research design, the study population covered all the six girls’ secondary schools in the district which also represented sample schools from which data was collected. Semi-structured questionnaires and document analysis sheets were used as instruments of data collection. The primary data collected was analysed by use of Statistical Package for Social Sciences (SPSS) version 17. Descriptive and inferential statistics were derived viz mean scores, percentages, correlation and regression coefficients. The Chi-square and one way ANOVA test statistics was used in hypothesis testing. Correlation and regression analysis were generated at 0.05 (2-tailed) and 0.001(2-tailed) significance levels. The findings from the study explained why form four girls in Kitui County were not doing well in SMT subjects. The outcome of the study is expected to influence policy and decision-making on girls’ better performance in the subjects. Different approaches were recommended based on the findings to improve girls’ performance in SMT subjects. Key words: determinants, girls’ performance, science, mathematics, technology, public secondary schools, Kenya.
Attitudes towards immigrants and the integration of ethnically diverse societies

The paper aims to clarify the possible determinants of peoples’ attitudes towards immigrants depending on their personal characteristics as well as attitudes towards households’ socio-economic stability and a country's institutions relying on the data of the European Social Survey fourth round database. The study intends to provide empirical evidence-based grounds for the development of policy measures to integrate ethnically diverse societies, taking into account the composition of the country's population as well as other country’s peculiarities. The results of the empirical analysis are consistent with several theoretical approaches explaining individual and collective determinants of people’s attitudes towards immigrants. Ethnic minorities, urban people, people with higher education and income, as well as people who have work experience abroad are, as a rule, more tolerant towards immigrants in Europe. Furthermore, people whose attitudes to socio-economic risks are lower and who evaluate the political and legal systems of a country and its police higher are more tolerant towards immigrants. The respondents’ labour market status (employed, unemployed) does not have a statistically significant relationship with their attitudes towards immigrants. In addition to the respondent’s personal characteristics and their attitudes, the collective determinants depending on country specific conditions measured by country dummies are valid in explaining people’s attitudes towards immigration.
Chronic Kidney Disease analysis using data mining classification techniques

Data mining has been a current trend for attaining diagnostic results. Huge amount of unmined data is collected by the healthcare industry in order to discover hidden information for effective diagnosis and decision making. Data mining is the process of extracting hidden information from massive dataset, categorizing valid and unique patterns in data. There are many data mining techniques like clustering, classification, association analysis, regression etc. The objective of our paper is to predict Chronic Kidney Disease(CKD) using classification techniques like Naive Bayes and Artificial Neural Network(ANN). The experimental results implemented in Rapidminer tool show that Naive Bayes produce more accurate results than Artificial Neural Network.
Melanoma Disease Progression or Associated Protection Ongoing Priming of Naive CD 8 T Cells for Autoimmune Vitiligo Does Not Require the

Vitiligo is a CD8 T cell–mediated autoimmune disease that has been shown to promote the longevity of memory T cell responses to melanoma. However, mechanisms whereby melanocyte/melanoma Ag-specific T cell responses are perpetuated in the context of vitiligo are not well understood. These studies investigate the possible phenomenon of naive T cell priming in hosts with melanoma-initiated, self-perpetuating, autoimmune vitiligo. Using naive pmel (gp100 25–33 –specific) transgenic CD8 T cells, we demonstrate that autoimmune melanocyte destruction induces naive T cell proliferation in skin-draining lymph nodes, in an Ag-dependent fashion. These pmel T cells upregulate expression of CD44, P-selectin ligand, and granzyme B. However, they do not downregulate CD62L, nor do they acquire the ability to produce IFN-g, indicating a lack of functional priming. Accordingly, adult thymectomized mice exhibit no reduction in the severity or kinetics of depigmentation or long-lived protection against melanoma, indicating that the continual priming of naive T cells is not required for vitiligo or its associated antitumor immunity. Despite this, depletion of CD4 T cells during the course of vitiligo rescues the priming of naive pmel T cells that are capable of producing IFN-g and persisting as memory, suggesting an ongoing and dominant mechanism of suppression by regulatory T cells. This work reveals the complex regulation of self-reactive CD8 T cells in vitiligo and demonstrates the overall poorly immunogenic nature of this autoimmune disease setting. T he autoimmune destruction of melanocytes, known as vit-iligo, has long been recognized as an independent positive prognostic factor for melanoma patients, correlating with improved overall and tumor-free survival rates (1–4). Our work has recently shown that vitiligo is also a key determinant for the generation of long-lived memory CD8 T cell responses to melanoma (5). We found that melanocyte Ags, which are liberated during the course of autoimmune vitiligo, are required to maintain nonexhausted and functional memory CD8 T cell responses against melanoma (5). Thus, there exists a causal relationship between tissue-specific autoimmunity and the maintenance of immunity to cancer. Understanding the mechanisms whereby autoimmunity is perpetuated is now an important component in understanding how antitumor immunity can be optimally maintained. However, the ontogeny of melanocyte/melanoma Ag-specific T cells in hosts with vitiligo remains incompletely understood. Although we have shown that vitiligo maintains populations of melanoma-primed CD8 T cells for many months as memory (5), it remains unclear whether the ongoing destruction of melanocytes also drives the continual priming of new …
Monetary Policy and the Political Support for a Labor Market Reform

Lagged benefits relative to costs can politically block an efficiency-enhancing labor market reform, lending support to the two-handed approach. An accommodating monetary policy, conducted alongside the reform, could help bringing the positive effects of the reform to the fore. In order to identify the mechanisms through which monetary policy may affect the political sustainability of a reform, we add stylized features of the labor market to a standard New-Keynesian model for monetary policy analysis. A labor market reform is modeled as a structural change inducing a permanent shift in the flexible-price unemployment and output levels. In addition to the permanent gains, the impact of the timing and magnitude of the reform-induced adjustments on the welfare of workers - employed and unemployed - is crucial to the political feasibility of the reform. Since the adjustments depend, on one hand, on the macroeconomic structure and, on the other hand, can be influenced by monetary policy, we simulate various degrees of output persistence across different policy rules. We find that, if inertias are present, monetary policy, even when conducted by an independent central bank, affects the political support for the reform. In general, the more expansionary (or the less contractionary) the policy is, the faster is the recovery to the new steady-state equilibrium and, thus, the stronger is the political support.
Applying the Uses and Gratifications Theory to Compare Higher Education Students' Motivation for Using Social Networking Sites: Experiences from Iran, Malaysia, United Kingdom, and South Africa.

Drawing from the Uses and Gratifications Theory, this study examined the Gratification Sought and the Gratification Obtained from using Social Networking Sites among Iranian, Malaysian, British, and South African higher education students. This comparison allowed to drawing conclusions about how social networking sites fulfill users’ needs with different cultures. Data were collected through a quantitative study applying online and paper- based questionnaire carried out in 2013, using a representative sample (N=320). Findings showed differences in students’ motivation to join to and to use of social network sites in each country. Interestingly, the researchers found that cultural differences may determine the uses and gratifications of social networking sites.
Real-Time Counting People in Crowded Areas by Using Local Empirical Templates and Density Ratios

In this paper, a fast and automated method of counting pedestrians in crowded areas is proposed along with three contributions. We firstly propose Local Empirical Templates (LET), which are able to outline the foregrounds, typically made by single pedestrians in a scene. LET are extracted by clustering foregrounds of single pedestrians with similar features in silhouettes. This process is done automatically for unknown scenes. Secondly, comparing the size of group foreground made by a group of pedestrians to that of appropriate LET captured in the same image patch with the group foreground produces the density ratio. Because of the local scale normalization between sizes, the density ratio appears to have a bound closely related to the number of pedestrians who induce the group foreground. Finally, to extract the bounds of density ratios for groups of different number of pedestrians, we propose a 3D human models based simulation in which camera viewpoints and pedestrians’ proximity are easily manipulated. We collect hundreds of typical occluded-people patterns with distinct degrees of human proximity and under a variety of camera viewpoints. Distributions of density ratios with respect to the number of pedestrians are built based on the computed density ratios of these patterns for extracting density ratio bounds. The simulation is performed in the offline learning phase to extract the bounds from the distributions, which are used to count pedestrians in online settings. We reveal that the bounds seem to be invariant to camera viewpoints and humans’ proximity. The performance of our proposed method is evaluated with our collected videos and PETS 2009’s datasets. For our collected videos with the resolution of 320x240, our method runs in real-time with good accuracy and frame rate of around 30 fps, and consumes a small amount of computing resources. For PETS 2009’s datasets, our proposed method achieves competitive results with other methods tested on the same datasets [1], [2]. key words: local empirical templates, local density ratios, density ratio bounds, and people counting
The Influence of the Annual Number of Storms on the Derivation of the Flood Frequency Curve through Event-Based Simulation

This study addresses the question of how to select the minimum set of storms that should be simulated each year in order to estimate an accurate flood frequency curve for return periods ranging between 1 and 1000 years. The Manzanares basin (Spain) was used as a study case. A continuous 100,000-year hourly rainfall series was generated using the stochastic spatial–temporal model RanSimV3. Individual storms were extracted from the series by applying the exponential method. For each year, the extracted storms were transformed into hydrographs by applying an hourly time-step semi-distributed event-based rainfall–runoff model, and the maximum peak flow per year was determined to generate the reference flood frequency curve. Then, different flood frequency curves were obtained considering the N storms with maximum rainfall depth per year, with 1 ≤ N ≤ total number of storms. Main results show that: (a) the degree of alignment between the calculated flood frequency curves and the reference flood frequency curve depends on the return period considered, increasing the accuracy for higher return periods; (b) for the analyzed case studies, the flood frequency curve for medium and high return period (50 ≤ return period ≤ 1000 years) can be estimated with a difference lower than 3% (compared to the reference flood frequency curve) by considering the three storms with the maximum total rainfall depth each year; (c) when considering only the greatest storm of the year, for return periods higher than 10 years, the difference for the estimation of the flood frequency curve is lower than 10%; and (d) when considering the three greatest storms each year, for return periods higher than 100 years, the probability of achieving simultaneously a hydrograph with the annual maximum peak flow and the maximum volume is 94%.
Subcontracting and Supplier Innovativeness in a Developing Economy: Evidence from China's Information and Communication Technology Industry

Sun Y. , Zhou Y. , Lin G. C. S. and Wei Y. H. D. Subcontracting and supplier innovativeness in a developing economy: evidence from China's information and communication technology industry, Regional Studies. This study critically evaluates the relevance of the global value chains theory against the actual practices of subcontracting and technological innovation in China based on a large-scale empirical firm survey in the information and communication technology industry. The results suggest that the impact of subcontracting depends on local suppliers’ absorptive capabilities; that the impact of global value chains on local technology upgrading is not linear; and an overdependence on subcontracting for the global market could hurt technological innovation.
Lost in Transition: The Reality of Reform in a Local SOE in Modernising China

China? s SOE restructuring has always been an important challenge in the country? s economic reform. However, despite a growing literature dealing with the macro perspective of China? s SOE reform and the large national champions in the country, there have been few attempts to focus on the smaller local SOEs and their employees who also endured all these massive economic and social changes. This study, based on interviewing employees of a once successful small SOE in Suzhou China about their dramatic work-life changes provides another angle to examine China? s SOE reform. It also presents the impacts of the reform measures on a company and, more importantly, on its employees, by allowing the employees to make their own interpretation on the SOE reform and the changes. By doing so, it brings recognition to the employees of China? s local SOEs who seemed to be ignored in past studies and connects the macroeconomic policies and reform measures in China? s transitional period to a more concrete discussion of the actual individuals involved.