Miracle-dz/UniFAR-FTUs huggingface dataset:
Temporal binding function of dorsal CA1 is critical for declarative memory formation

Significance Our ability to form declarative memories depends on the hippocampus, and this capacity degrades with age. To identify the critical determinants of this age-associated memory loss, we explored the relationships between two functions of the hippocampus known to be age-sensitive, temporal binding and relational organization. We found that (i) temporal binding relies on the activity of the dorsal (d)CA1 subfield across temporal gaps between events; and (ii) loss in this dCA1-dependent function, through ensuing disruption of relational organization, is the primary cause of declarative memory loss occurring in aging. Temporal binding, the process that enables association between discontiguous stimuli in memory, and relational organization, a process that enables the flexibility of declarative memories, are both hippocampus-dependent and decline in aging. However, how these two processes are related in supporting declarative memory formation and how they are compromised in age-related memory loss remain hypothetical. We here identify a causal link between these two features of declarative memory: Temporal binding is a necessary condition for the relational organization of discontiguous events. We demonstrate that the formation of a relational memory is limited by the capability of temporal binding, which depends on dorsal (d)CA1 activity over time intervals and diminishes in aging. Conversely, relational representation is successful even in aged individuals when the demand on temporal binding is minimized, showing that relational/declarative memory per se is not impaired in aging. Thus, bridging temporal intervals by dCA1 activity is a critical foundation of relational representation, and a deterioration of this mechanism is responsible for the age-associated memory impairment.
Derivation of Occupational Thresholds of Toxicological Concern for Systemically Acting Noncarcinogenic Organic Chemicals

Many substances in workplace do not have occupational exposure limits. The threshold of toxicological concern (TTC) principle is part of the hierarchy of approaches useful in occupational health risk assessment. The aim of this study was to derive occupational TTCs (OTTCs) reflecting the airborne concentrations below which no significant risk to workers would be anticipated. A reference dataset consisting of the 8-h threshold limit values-Time-Weighted Average for 280 organic substances was compiled. Each substance was classified into low (class I), intermediate (class II), or high (class III) hazard categories as per Cramer rules. For each chemical, n-octanol:water partition coefficient and vapor pressure along with the molecular weight were used to predict the blood:air partition coefficient. The blood:air partition coefficient along with data on water solubility and ventilation rate allowed the prediction of pulmonary retention factor and absorbed dose in workers. For each Cramer class, the distribution of the predicted doses was analyzed to identify the various percentile values corresponding to the OTTC. Accordingly, for Cramer classes I-III, the OTTCs derived in this study correspond to 0.15, 0.0085, and 0.006 mmol/d, respectively, at the 10th percentile level, while these values were 1.5, 0.09 and 0.03 mmol/d at the 25th percentile level. The proposed OTTCs are not meant to replace the traditional occupational exposure limits, but can be used in data-poor situations along with exposure estimates to support screening level risk assessment and prioritization.
Electrical physiological evidence for highand low-affinity vagal CCK-A receptors.

We have demonstrated that under physiological conditions CCK acts through vagal high-affinity CCK-A receptors to mediate pancreatic secretion. In this study, we evaluated the vagal afferent response to endogenous CCK in rats and defined the CCK-receptor affinity states and the vagal-receptive field responsive to CCK stimulation using electrophysiological studies. Experiments were performed on anesthetized rats prepared with bile-pancreatic fistula. Plasma CCK levels were elevated by diverting bile-pancreatic juice (BPJ). The single-unit discharge of sensory neurons supplying the gastrointestinal tract was recorded from the nodose ganglia. All units studied were either silent or they had a very low resting discharge frequency. Thirty-two single units were studied extensively; seven were shown to be stimulated by diversion of BPJ (2.6 ± 2 impulses/min at basal to 40 ± 12 impulses/min after diversion). Acute subdiaphragmatic vagotomy or perivagal capsaicin treatment abolished the response. The CCK-A-receptor antagonist CR-1409, but not the CCK-B antagonist L-365260, blocked the vagal response to endogenous CCK stimulation. Infusion of the low-affinity CCK-receptor antagonist CCK-JMV-180 completely blocked the vagal afferent response to the diversion of BPJ in three of seven rats tested but had no effect on the response in the remaining four. In a separate study, we demonstrated that gastric, celiac, or hepatic branch vagotomy abolished the response in different subgroups of neurons. In conclusion, under physiological conditions, CCK acts on both high- and low-affinity CCK-A receptors present on distinct vagal afferent fibers. The vagal CCK-receptor field includes the regions innervated by the gastric, celiac, and hepatic vagal branches. This study provides electrophysiological evidence that vagal CCK receptors are present on the vagal gastric, celiac, and hepatic branches and may occur in high- and low-affinity states.
EMISSION LINES FROM THE GAS DISK AROUND TW HYDRA AND THE ORIGIN OF THE INNER HOLE

We compare line emission calculated from theoretical disk models with optical to submillimeter wavelength observational data of the gas disk surrounding TW Hya and infer the spatial distribution of mass in the gas disk. The model disk that best matches observations has a gas mass ranging from ∼10−4 to 10−5 M☉ for 0.06 AU < r < 3.5 AU and ∼0.06 M☉ for 3.5 AU < r < 200 AU. We find that the inner dust hole (r < 3.5 AU) in the disk must be depleted of gas by ∼1–2 orders of magnitude compared with the extrapolated surface density distribution of the outer disk. Grain growth alone is therefore not a viable explanation for the dust hole. CO vibrational emission arises within r ∼ 0.5 AU from thermal excitation of gas. [O i] 6300 Å and 5577 Å forbidden lines and OH mid-infrared emission are mainly due to prompt emission following UV photodissociation of OH and water at r ≲ 0.1 AU and at r ∼ 4 AU. [Ne ii] emission is consistent with an origin in X-ray heated neutral gas at r ≲ 10 AU, and may not require the presence of a significant extreme-ultraviolet (hν > 13.6 eV) flux from TW Hya. H2 pure rotational line emission comes primarily from r ∼ 1 to 30 AU. [O i] 63 μm, HCO+, and CO pure rotational lines all arise from the outer disk at r ∼ 30–120 AU. We discuss planet formation and photoevaporation as causes for the decrease in surface density of gas and dust inside 4 AU. If a planet is present, our results suggest a planet mass ∼4–7 MJ situated at ∼3 AU. Using our photoevaporation models and the best surface density profile match to observations, we estimate a current photoevaporative mass loss rate of 4 × 10−9 M☉ yr−1 and a remaining disk lifetime of ∼5 million years.
Breast tumor characteristics as predictors of mammographic detection: comparison of interval- and screen-detected cancers.

BACKGROUND Although mammographic screening is useful for detecting early breast cancer, some tumors are detected in the interval between screening examinations. This study attempted to characterize fully the tumors detected in the two different manners. METHODS Our study utilized a case-control design and involved a cohort of women undergoing mammographic screening within the defined population of a health maintenance organization (the Group Health Cooperative of Puget Sound). Women were classified as having "interval" or "interval-detected" cancers (n = 150) if their diagnosis was made within 24 months after a negative-screening mammogram or one that indicated a benign condition. Cancers were classified as "screen detected" (n = 279) if the diagnosis occurred after a positive assessment by screening mammography. Tumors from women in each group were evaluated for clinical presentation, histology, proliferative characteristics, and expression of hormone receptors, p53 tumor suppressor protein, and c-erbB-2 protein. RESULTS Interval-detected cancers occurred more in younger women and were of larger tumor size than screen-detected cancers. In unconditional logistic regression models adjusted for age and tumor size, tumors with lobular (odds ratio [OR] = 1.9; 95% confidence interval [CI] = 0.9-4.2) or mucinous (OR = 5.5; 95% CI = 1.5-19.4) histology, high proliferation (by either mitotic count [OR = 2.9; 95% CI = 1.5-5.7] or Ki-67 antigen expression [OR = 2.3; 95% CI = 1.3-4.1]), high histologic grade (OR = 2.1; 95% CI = 1.2-4.0), high nuclear grade (OR = 2.0; 95% CI = 1.0-3.7), or negative estrogen receptor status (OR = 1.8; 95% CI = 1.0-3.1) were more likely to surface in the interval between screening examinations. Tumors with tubular histology (OR = 0.2; 95% CI = 0.0-0.8) or with a high percentage of in situ components (50%) (OR = 0.5; 95% CI = 0.2-1.2) were associated with an increased likelihood of screen detection. CONCLUSIONS Our data from a large group of women in a defined population indicate that screening mammography may miss tumors of lobular or mucinous histology and some rapidly proliferating, high-grade tumors.
Perceptions of Child Maltreatment by Parents from the Indian Subcontinent: Challenging Myths About Culturally Based Abusive Parenting Practices

Clinicians and researchers emphasize the importance of recognizing differential cross-cultural definitions of child maltreatment, cautioning awareness that some ethnic groups may use harsher methods to discipline their children. Using a mixed-method research approach, based on questionnaire and focus group data, 29 parents of South Asian descent provided input on their attitudes toward child discipline, maltreatment, and neglect. Study findings suggest that South Asian parents do not differ significantly from other populations in their judgment of appropriate parenting approaches; that is, persistent and excessive use of physical discipline was considered to be inappropriate, behaviors of parents that may have negative emotional consequences for children were recognized as inappropriate, and lack of proper supervision of children was seen as a concern. Notably, though, participants voiced their reluctance to contact child protective services should they encounter families struggling with abuse. Implications for practice and directions for future research are suggested.
The relationship between double-diffusive intrusions and staircases in the Arctic Ocean

AbstractThe origin of double-diffusive staircases in the Arctic Ocean is investigated for the particular background setting in which both temperature and salinity increase with depth. Motivated by observations that show the coexistence of thermohaline intrusions and double-diffusive staircases, a linear stability analysis is performed on the governing equations to determine the conditions under which staircases form. It is shown that a double-diffusive staircase can result from interleaving motions if the observed bulk vertical density ratio is below a critical vertical density ratio estimated for particular lateral and vertical background temperature and salinity gradients. Vertical background temperature and salinity gradients dominate over horizontal gradients in determining whether staircases form, with the linear theory indicating that perturbations to stronger vertical temperature gradients are more likely to give rise to a staircase. Examination of Arctic Ocean temperature and salinity measurements.
An empirical comparison of visualization tools to assist information retrieval on the web

Visualizations of subspaces on the World Wide Web can provide users the ability to identify relevant information from a set of Web pages, while gaining new insights or understanding of the space. This study tested three classes of visualization techniques, distortion, zoom, and expanding outline, to better understand which classes of visualization techniques may better represent the underlying structure. The effects of different visualization techniques on user performance on information searching tasks and the effects of different sizes of the Web spaces were studied. Eighty participants were asked to search information with and without a visualization tool over the large Web space. The factors that may have caused cognitive overloads are further discussed.
Interdiffusion of PCBM and P3HT Reveals Miscibility in a Photovoltaically Active Blend

Developing a better understanding of the evolution of morphology in plastic solar cells is the key to designing new materials and structures that achieve photoconversion efficiencies greater than 10%. In the most extensively characterized system, the poly(3‐hexyl thiophene) (P3HT):[6,6]‐phenyl‐C61‐butyric‐acid‐methyl‐ester (PCBM) bulk heterojunction, the origins and evolution of the blend morphology during processes such as thermal annealing are not well understood. In this work, we use a model system, a bilayer of P3HT and PCBM, to develop a more complete understanding of the miscibility and diffusion of PCBM within P3HT during thermal annealing. We find that PCBM aggregates and/or molecular species are miscible and mobile in disordered P3HT, without disrupting the ordered lamellar stacking of P3HT chains. The fast diffusion of PCBM into the amorphous regions of P3HT suggests the favorability of mixing in this system, opposing the belief that phase‐pure domains form in BHJs due to immiscibility of these two components.
Expressing anger and joy with the size code

This paper reports our finding of the use of a proposed biological code – the size code in anger and joy speech. In searching for explanations for an F0 peak delay phenomenon related to angry speech that cannot be accounted for by known articulatory constraints, we hypothesized that the delay was due to the lowering of the larynx to exaggerate body size, a biological code known to be used by animals. Our analysis of the formant frequencies in existing emotional speech databases revealed that anger speech had lowered formants and joy speech had raised formants. The results confirm our hypothesis and suggest that the size code is being actively used by humans to express emotions.
Trends in Retention on Antiretroviral Therapy in National Programs in Low-Income and Middle-Income Countries

Objectives:To document regional and global trends for patients retained on antiretroviral therapy (ART) 12-48 months after treatment initiation, in low-income and middle-income countries. Methods:Data reported by national programs to WHO/UNICEF/UNAIDS in 2008 were aggregated to produce regional and global estimates. The proportion of patients on ART at 12, 24, 36, and 48 months is derived from cohort monitoring systems in ART dispensing facilities. Results:Of 149 countries, 70 (47%) reported on retention at 12 months, 54 (36%) at 24 months, 38 (26%) at 36 months, and 30 (20%) at 48 months. Regional and global trends showed that the majority of attrition from ART programs occurred within the first year and declined thereafter. Among countries in sub-Saharan Africa, retention on ART was estimated at 75.2% at 12 months, 66.8% at 24 months, and remained at a similar level up to 48 months. Conclusions:After high attrition in the first year, retention on ART tends to stabilize. In the literature, attrition in the first year was related to early mortality. Earlier presentation for diagnosis of HIV infection, timely screening, and access to ART are fundamental to reduce it. Countries need support in reporting on outcomes on ART.
Purification of a 54-kilodalton protein (OprJ) produced in NfxB mutants of Pseudomonas aeruginosa and production of a monoclonal antibody specific to OprJ

The 54-kDa outer membrane protein (designated OprJ) of a norfloxacin-resistant nfxB mutant of Pseudomonas aeruginosa PAO1 was purified by ion-exchange high-performance liquid chromatography. Mobility of OprJ in sodium dodecyl sulfate-polyacrylamide gel electrophoresis was not affected by reduction and heating. A murine monoclonal antibody (MAb) against OprJ was prepared to investigate existence of this protein in fluoroquinolone-susceptible and -resistant strains of P. aeruginosa. Western blot (immunoblot) analysis with this MAb revealed a single band at the position corresponding to OprJ in outer membrane proteins of NfxB mutants derived from clinical isolates. However, the MAb did not react with any outer membrane proteins of the respective parent strains. Complementation of the NfxB mutation by transformation with plasmid pNF111, which contained the wild-type nfxB gene, led to disappearance of the single band corresponding to OprJ. The existence of OprJ was associated with fluoroquinolone resistance. Furthermore, the MAb did not react with any outer membrane proteins of other fluoroquinolone-resistant nalB and nfxC mutants. These results suggest that OprJ is newly produced in NfxB mutants of P. aeruginosa and is involved in fluoroquinolone resistance specific to NfxB, and it appears that the MAb to OprJ should aid in detection of the NfxB mutation in P. aeruginosa.
Treatment technologies and mechanisms for three odorants at trace level: IPMP, IBMP, and TCA

Odour episodes caused by algal metabolites are gaining more and more attention in recent years. Besides geosmin and 2-methylisoborneol (MIB), 2-isopropyl-3-methoxypyrazine (IPMP), 2-isobutyl-3-methoxypyrazine (IBMP), and 2,4,6-trichloroanisole (TCA) have emerged to be important off-flavour sources. Their low odour threshold concentrations (several ng ·L−1), which are even lower than those of MIB and geosmin, pose challenges for treatment strategies. Hence, a practical and efficient mitigation technology is needed. The possible practical technologies, including powdered activated carbon (PAC) adsorption and oxidation by chlorine and potassium permanganate, were investigated. The results indicated that chlorine and potassium permanganate oxidation of the three odorants were unfeasible while PAC adsorption was effective. As for adsorption, TCA, followed by IBMP and IPMP, was most easily removed by PAC. The Freundlich model could well describe the adsorption isotherm data. The adsorption capacities for IPMP, IBMP, and TCA were described as follows: , , and . For five earthy/musty odorants including geosmin and MIB, octanol/water partition coefficient, molecular weight, and polarizability all promoted adsorption while aqueous solubility showed a negative influence. The hydrophobic interaction was believed to be the dominant force in the adsorption mechanism while the π-electron interaction enhanced adsorption when a benzene ring was present. This result could be used to predict the adsorption performance of emerging odorants.
BMP4 Sufficiency to Induce Choroid Plexus Epithelial Fate from Embryonic Stem Cell-Derived Neuroepithelial Progenitors

Choroid plexus epithelial cells (CPECs) have essential developmental and homeostatic roles related to the CSF and blood–CSF barrier they produce. Accordingly, CPEC dysfunction has been implicated in many neurological disorders, such as Alzheimer's disease, and transplant studies have provided proof-of-concept for CPEC-based therapies. However, such therapies have been hindered by the inability to expand or generate CPECs in culture. During development, CPECs differentiate from preneurogenic neuroepithelial cells and require bone morphogenetic protein (BMP) signaling, but whether BMPs suffice for CPEC induction is unknown. Here we provide evidence for BMP4 sufficiency to induce CPEC fate from neural progenitors derived from mouse embryonic stem cells (ESCs). CPEC specification by BMP4 was restricted to an early time period after neural induction in culture, with peak CPEC competency correlating to neuroepithelial cells rather than radial glia. In addition to molecular, cellular, and ultrastructural criteria, derived CPECs (dCPECs) had functions that were indistinguishable from primary CPECs, including self-assembly into secretory vesicles and integration into endogenous choroid plexus epithelium following intraventricular injection. We then used BMP4 to generate dCPECs from human ESC-derived neuroepithelial cells. These findings demonstrate BMP4 sufficiency to instruct CPEC fate, expand the repertoire of stem cell-derived neural derivatives in culture, and herald dCPEC-based therapeutic applications aimed at the unique interface between blood, CSF, and brain governed by CPECs.
Analysis of millimetre-wave polarization diverse multiple-input multiple-output capacity

Millimetre-waves offer the possibility of wide bandwidth and consequently high data rate for wireless communications. For both uni- and dual-polarized systems, signals sent over a link may suffer severe degradation due to antenna misalignment. Orientation robustness may be enhanced by the use of mutual orthogonality in three dimensions. Multiple-input multiple-output polarization diversity offers a way of improving signal reception without the limitations associated with spatial diversity. Scattering effects often assist propagation through multipath. However, high path loss at millimetre-wave frequencies may limit any reception enhancement through scattering. We show that the inclusion of a third orthogonal dipole provides orientation robustness in this setting, as well as in a rich scattering environment, by means of a Rician fading channel model covering all orientations for a millimetre-wave, tri-orthogonal, half-wave dipole transmitter and receiver employing polarization diversity. Our simulation extends the analysis into three dimensions, fully exploiting individual sub-channel paths. In both the presence and absence of multipath effects, capacity is observed to be higher than that of a dual-polarized system over the majority of a field of view.
A Measurement‐Model Fusion Approach for Improved Wet Deposition Maps and Trends

Air quality models provide spatial fields of wet deposition (WD) and dry deposition that explicitly account for the transport and transformation of emissions from thousands of sources. However, many sources of uncertainty in the air quality model including errors in emissions and meteorological inputs (particularly precipitation) and incomplete descriptions of the chemical and physical processes governing deposition can lead to bias and error in the simulation of WD. We present an approach to bias correct Community Multiscale Air Quality model output over the contiguous United States using observation‐based gridded precipitation data generated by the Parameter‐elevation Regressions on Independent Slopes Model and WD observations at the National Atmospheric Deposition Program National Trends Network sites. A cross‐validation analysis shows that the adjusted annual accumulated WD for NO3−, NH4+, and SO42− from 2002 to 2012 has less bias and higher correlation with observed values than the base model output without adjustment. Temporal trends in observed WD are captured well by the adjusted model simulations across the entire contiguous United States. Consistent with previous trend analyses, WD NO3− and SO42− are shown to decrease during this period in the eastern half of the United States, particularly in the Northeast, while remaining nearly constant in the West. Trends in WD of NH4+ are more spatially and temporally heterogeneous, with some positive trends in the Great Plains and Central Valley of CA and slightly negative trends in the south.