Miracle-dz/UniFAR-FTUs huggingface dataset:
Nearest-Neighbor and Clustering based Anomaly Detection Algorithms for RapidMiner

Unsupervised anomaly detection is the process of ﬁnding outlying records in a given dataset without prior need for training. In this paper we introduce an anomaly detection extension for RapidMiner in order to assist non-experts with applying eight diﬀerent nearest-neighbor and clustering based algorithms on their data. A focus on eﬃcient implementation and smart parallelization guarantees its practical applicability. In the context of clustering-based anomaly detection, two new algorithms are introduced: First, a global variant of the cluster-based local outlier factor (CBLOF) is introduced which tries to compensate the shortcomings of the original method. Second, the local density cluster-based outlier factor (LDCOF) is introduced which takes the local variances of clusters into account. The performance of all algorithms have been evaluated on real world datasets from the UCI machine learning repository. The results reveal the strengths and weaknesses of the single algorithms and show that our proposed clustering based algorithms out-perform CBLOF signiﬁcantly.
Myeloid-Derived Suppressor Cells in Bacterial Infections

Myeloid-derived suppressor cells (MDSCs) comprise monocytic and granulocytic innate immune cells with the capability of suppressing T- and NK-cell responses. While the role of MDSCs has been studied in depth in malignant diseases, the understanding of their regulation and function in infectious disease conditions has just begun to evolve. Here we summarize and discuss the current view how MDSCs participate in bacterial infections and how this knowledge could be exploited for potential future therapeutics.
Kinematical Analysis of Forehand and Backhand Smash in Badminton

In badminton, it demands excellent physical fitness and good motor coordination for the development ofsophisticated racquet movement. This study aims at identifying the difference of forehand and back handsmash performed by elite male badminton players during North-Zone intervarsity at A.M.U, Aligarh2009-2010. The parameters to study were focused on upper arm, forearm and wrist segments. SiliconCoach Pro-7 motion analysis software and two legria Canon SF-10 cameras system were used to recordand analyze the performance of the subjects. Six male participants served as the subjects. Results of thestudy shows that there is no significant differences exist between forehand and back hand smash inbadminton player as flight angle, shoulder angle, elbow angle and angular velocity of wrist joint. Whereassignificance differences exist between forehand and back hand smash in badminton players as shuttlevelocity, contact height, racket angle, wrist angle, angular velocity of shoulder joint and elbow joints.Appropriate coaching cues are devised to assist coaches and players in assessing and improvingperformance. Keywords : badminton, biomechanics, power strokes, joint actions
Detection of SARS Coronavirus in Patients with Suspected SARS

Cases of severe acute respiratory syndrome (SARS) were investigated for SARS coronavirus (SARS-CoV) through RNA tests, serologic response, and viral culture. Of 537 specimens from patients in whom SARS was clinically diagnosed, 332 (60%) had SARS-CoV RNA in one or more clinical specimens, compared with 1 (0.3%) of 332 samples from controls. Of 417 patients with clinical SARS from whom paired serum samples were available, 92% had an antibody response. Rates of viral RNA positivity increased progressively and peaked at day 11 after onset of illness. Although viral RNA remained detectable in respiratory secretions and stool and urine specimens for >30 days in some patients, virus could not be cultured after week 3 of illness. Nasopharyngeal aspirates, throat swabs, or sputum samples were the most useful clinical specimens in the first 5 days of illness, but later in the illness viral RNA could be detected more readily in stool specimens.
The Impact of Emotions on Trust Decisions

Researchers have recognized that interpersonal trust consists of different dimensions. These dimensions suggest that trust can be rational, cognitive, or affective. Affect, which includes moods and emotions, is likely to have a direct impact on the affective dimension. On the other hand, there are also studies showing that affect indirectly influence cognitive judgments. Nonetheless, in this chapter we argue that the impact of affect on judgment will not be the same on all individuals. In effect, the impact varies, depending on the individual's attention to affect, motivation to use or guard against affect, or regulation of affect. All this may suggest that an individual's abilities or tendencies to manage affect will have implication on his or her trust relationships with others.
PENGARUH KEJELASAN SASARAN ANGGARAN TERHADAP SENJANGAN ANGGARAN INSTANSI PEMERINTAH DAERAH DENGAN KOMITMEN ORGANISASI SEBAGAI PEMODERASI

Tujuan penelitian ini adalah untuk mengetahui apakah kejelasan sasaran anggaran berpengaruh terhadap senjangan anggaran instansi pemerintah daerah dan untuk mengetahui apakah kejelasan sasaran anggaran dengan komitmen organisasi sebagai variabel moderating berpengaruh terhadap senjangan anggaran instansi pemerintah daerah. Penelitian ini menggunakan metode purposive sampling, jumlah kuesioner yang didistribusikan pada penelitian ini sebanyak 130 lembar dan yang dapat diolah sebanyak 87 lembar dengan rata-rata 66,92%. Penelitian ini menggunakan data dari 87 pejabat-pejabat struktural yang memiliki jabatan sebagai kepala dinas, kepala sub dinas, kepala bagian dan kepala sub bagian pada semua dinas pemerintah Kota Bengkulu. Hipotesis pertama diuji dengan regresi linier sederhana, sedangkan untuk hipotesis kedua menggunakan analisis Moderated Regression Analysis (MRA) dengan model selisih mutlak. Hasil penelitian ini menunjukkan bahwa yang pertama, kejelasan sasaran anggaran berpengaruh positif dan signifikan terhadap senjangan anggaran. Hal ini berarti bahwa adanya kejelasan sasaran anggaran akan meningkatkan terjadinya senjangan anggaran. Kedua, penelitian ini juga menemukan bahwa kejelasan sasaran anggaran dengan komitmen organisasi sebagai pemoderasi berpengaruh positif dan tidak signifikan terhadap senjangan anggaran pada instansi pemerintah Kota Bengkulu. Berdasarkan hasil penelitian, maka penelitian ini menyimpulkan bahwa komitmen organisasi bukan merupakan variabel moderating dalam hubungan antara kejelasan sasaran anggaran dan senjangan anggaran pada instansi pemerintah Kota Bengkulu.
Is athlete burnout more than just stress? A sport commitment perspective

This study examined athlete burnout from a commitment perspective, which suggests that athletes can be involved in sport for a combination of reasons related to sport attraction (want to be involved) and sport entrapment (have to be involved). According to this framework, athletes are likely to experience burnout if they are involved in sport primarily for entrapment-related reasons. Female and male age-group swimmers (N = 236) completed a questionnaire that assessed theoretical determinants of commitment and burnout (emotional/ physical exhaustion, swim devaluation, and reduced swim accomplishment). Cluster analysis was used to partition swimmers into profiles based on the theoretical determinants of commitment. Subsequent analyses of variance compared emergent cluster groups on burnout. Results revealed that athletes who exhibited characteristics reflecting sport entrapment generally demonstrated higher burnout scores than athletes who were primarily involved in sport for attraction-related reasons. The.
Clinical treatment of vulvar Paget's disease: a case report

Vulvar Paget's disease is very rare malignancy originating in vulvar apocrine-gland-bearing skin cells or as a manifestation of adjacent primary anal, rectal or bladder adenocarcinoma.1 It is also called extramammary Paget's disease and affects both sexes, in the vulvar, perineal or scrotal areas. Vulvar Paget's disease is most commonly seen in postmenopausal Caucasian females and appears clinically as red, eczematous and pruriginous – and sometimes painful – lesions. In most cases it is an intraepidermal adenocarcinoma in which tumor cells involve the epidermis and sometimes the underlying skin appendage, but sometimes there is focal dermal invasion.2 Probably because of its multicentric nature, Paget's disease has a chronic and relapsing course. Surgery has been the treatment of choice, but disease frequently extends far from the visible lesion and surgical margins are frequently positive. The Paget's cells are larger than keratinocytes, have clear chromatin, a prominent nucleolus and gray–blue cytoplasm and they may appear vacuolated with hematoxylin and eosin staining.3 All these characteristics are consistent with their glandular nature. Many patients undergo multiple surgical procedures, including wide local excision, simple vulvectomy or radical vulvectomy. However, the margins of primary surgical specimens are positive in more than half of the patients.3 Consequently, the recurrence rate is about 47%. 4 The disappointing results of surgical treatment and the high morbidity and side-effects of extensive vulvar resection have encouraged many authors to try innovative clinical treatment for vulvar Paget's disease.
Novel PKCα-mediated phosphorylation site(s) on cofilin and their potential role in terminating histamine release

PKCα phosphorylates cofilin at Ser-23 and/or Ser-24 during degranulation, and the novel phosphorylation contributes to F-actin remodeling by regulating the ability of cofilin to bind to 14-3-3ζ and to depolymerize and/or sever F-actin. This highly regulated mechanism is necessary for the proper termination of degranulation.
Stopping Rules for a Class of Sampling-Based Stochastic Programming Algorithms

Monte Carlo sampling-based algorithms hold much promise for solving stochastic programs with many scenarios. A critical component of such algorithms is a stopping criterion to ensure the quality of the solution. In this paper, we develop a stopping rule theory for a class of algorithms that estimate bounds on the optimal objective function value by sampling. We provide rules for selecting sample sizes and terminating the algorithm under which asymptotic validity of confidence intervals for the quality of the proposed solution can be verified. Empirical coverage results are given for a simple example.
A Chimeric Porcine Circovirus (PCV) with the Immunogenic Capsid Gene of the Pathogenic PCV Type 2 (PCV2) Cloned into the Genomic Backbone of the Nonpathogenic PCV1 Induces Protective Immunity against PCV2 Infection in Pigs

ABSTRACT Porcine circovirus type 2 (PCV2) is associated with postweaning multisystemic wasting syndrome in pigs, whereas PCV1 is nonpathogenic. We previously demonstrated that a chimeric PCV1-2 virus (with the immunogenic capsid gene of PCV2 cloned into the backbone of PCV1) induces an antibody response to the PCV2 capsid protein and is attenuated in pigs. Here, we report that the attenuated chimeric PCV1-2 induces protective immunity to wild-type PCV2 challenge in pigs. A total of 48 specific-pathogen-free piglets were randomly and equally assigned to four groups of 12 pigs each. Pigs in group 1 were vaccinated by intramuscular injection with 200 μg of the chimeric PCV1-2 infectious DNA clone. Pigs in group 2 were vaccinated by intralymphoid injection with 200 μg of a chimeric PCV1-2 infectious DNA clone. Pigs in group 3 were vaccinated by intramuscular injection with 103.5 50% tissue culture infective doses (TCID50) of the chimeric PCV1-2 live virus. Pigs in group 4 were not vaccinated and served as controls. By 42 days postvaccination (DPV), the majority of pigs had seroconverted to PCV2 capsid antibody. At 42 DPV, all pigs were challenged intranasally and intramuscularly with 2 × 104.5 TCID50 of a wild-type pathogenic PCV2 virus. By 21 days postchallenge (DPC), 9 out of the 12 group 4 pigs were viremic for PCV2. Vaccinated animals in groups 1 to 3 had no detectable PCV2 viremia after challenge. At 21 DPC the lymph nodes in the nonvaccinated pigs were larger (P < 0.05) than those of vaccinated pigs. The PCV2 genomic copy loads in lymph nodes were reduced (P < 0.0001) in vaccinated pigs. Moderate amounts of PCV2 antigen were detected in most lymphoid tissues of nonvaccinated pigs but in only 1 of 36 vaccinated pigs. Mild-to-severe lymphoid depletion and histiocytic replacement were detected in lymphoid tissues in the majority of nonvaccinated group 4 pigs but in only a few vaccinated group 1 to 3 pigs. The data from this study indicated that when given intramuscularly in pigs, the attenuated chimeric PCV1-2 live virus, as well as the chimeric PCV1-2 infectious DNA clone, induces protective immunity against PCV2 infection and could potentially serve as an effective vaccine.
Constructing and Evaluating a Novel Crowdsourcing-based Paraphrased Opinion Spam Dataset

Opinion spam, intentionally written by spammers who do not have actual experience with services or products, has recently become a factor that undermines the credibility of information online. In recent years, studies have attempted to detect opinion spam using machine learning algorithms. However, limitations of gold-standard spam datasets still prove to be a major obstacle in opinion spam research. In this paper, we introduce a novel dataset called Paraphrased OPinion Spam (POPS), which contains a new type of review spam that imitates real human opinions using crowdsourcing. To create such a seemingly truthful review spam dataset, we asked task participants to paraphrase truthful reviews, and include factual information and domain knowledge in their reviews. The classification experiments and semantic analysis results show that our POPS dataset most linguistically and semantically resembles truthful reviews. We believe that our new deceptive opinion spam dataset will help advance opinion spam research.
A Nonlinear Block Structure Identification Procedure Using Frequency Response Function Measurements

Based on simple frequency response function (FRF) measurements, we give the user some guidance in the selection of an appropriate nonlinear block structure for the system to be modeled. The method consists in measuring the FRF using a Gaussian-like input signal and varying in a first experiment the root-mean-square (rms) value of this signal while maintaining the coloring of the power spectrum. Next, in a second experiment, the coloring of the power spectrum is varied while keeping the rms value constant. Based on the resulting behavior of the FRF, an appropriate nonlinear block structure can be selected to approximate the real system. The identification of the selected block-oriented model itself is not addressed in this paper. A theoretical analysis and two practical applications of this structure identification method are presented for some nonlinear block structures.
Multiple factors correlating with wing malformations in the population of Parnassius apollo (Lepidoptera: Papilionidae) restituted from a low number of individuals: A mini review

The Apollo butterfly, Parnassius apollo (Linnaeus), was common in Europe over 100 years ago, but currently it is considered as near threatened. Different conservation programs have promoted the persistence of this species; however, it is still endangered. An example of such programs was the action devoted to reestablish the Apollo butterfly population in Pieniny National Park (Poland) from only 20–30 individuals which had survived till the last decade of the 20th century. This reintroduction has been successful; however, unexpected developmental problems appeared. Butterflies with deformed or reduced wings became frequent in the population living in the natural habitat, and particularly among those reared under seminatural conditions (in the same environment, but fenced by a net). Until recently, reasons for these malformations remained unknown. However, reports published during last months indicated that there are genetic, biochemical, and microbiological factors contributing to this phenomenon. In the malformed individuals, lesions in the wingless gene and dysfunctions of laccase 1 and 2 were found to be significantly more frequent than in normal insects. A large fraction of butterflies with deformed or reduced wings was devoid of the prokaryotic symbiont Wolbachia, which was present in most normal individuals. Moreover, Yersinia pseudotuberculosis (Pfeiffer) Smith and Thal, and Serratia sp. , bacteria pathogenic to insects, were detected in the biological material from both normal and malformed butterflies from this population. These findings are summarized and discussed in this review, in the light of conservation of insects and restitution of their populations from a low number of individuals.
Measuring situation awareness in emergency settings: a systematic review of tools and outcomes

Background Nontechnical skills have an impact on health care outcomes and improve patient safety. Situation awareness is core with the view that an understanding of the environment will influence decision-making and performance. This paper reviews and describes indirect and direct measures of situation awareness applicable for emergency settings. Methods Electronic databases and search engines were searched from 1980 to 2010, including CINAHL, Ovid Medline, Pro-Quest, Cochrane, and the search engine, Google Scholar. Access strategies included keyword, author, and journal searches. Publications identified were assessed for relevance, and analyzed and synthesized using Oxford evidence levels and the Critical Appraisal Skills Programme guidelines in order to assess their quality and rigor. Results One hundred and thirteen papers were initially identified, and reduced to 55 following title and abstract review. The final selection included 14 papers drawn from the fields of emergency medicine, intensive care, anesthetics, and surgery. Ten of these discussed four general nontechnical skill measures (including situation awareness) and four incorporated the Situation Awareness Global Assessment Technique. Conclusion A range of direct and indirect techniques for measuring situation awareness is available. In the medical literature, indirect approaches are the most common, with situation awareness measured as part of a nontechnical skills assessment. In simulation-based studies, situation awareness in emergencies tends to be suboptimal, indicating the need for improved training techniques to enhance awareness and improve decision-making.
Cold-nuclear-matter effects on heavy-quark production at forward and backward rapidity in d+Au collisions at sNN =200GeV

The PHENIX experiment has measured open heavy-flavor production via semileptonic decay over the transverse momentum range 1 < p(T) < 6 GeV/c at forward and backward rapidity (1.4 < vertical bar y vertical bar < 2.0) in d + Au and p + p collisions at root s(NN) = 200 GeV. In central d + Au collisions, relative to the yield in p + p collisions scaled by the number of binary nucleon-nucleon collisions, a suppression is observed at forward rapidity (in the d-going direction) and an enhancement at backward rapidity (in the Au-going direction). Predictions using nuclear-modified-parton-distribution functions, even with additional nuclear-p(T) broadening, cannot simultaneously reproduce the data at both rapidity ranges, which implies that these models are incomplete and suggests the possible importance of final-state interactions in the asymmetric d + Au collision system. These results can be used to probe cold-nuclear-matter effects, which may significantly affect heavy-quark production, in addition to helping constrain the magnitude of charmonia-breakup effects in nuclear matter.
Modeling Adoption Intention of Online Education in Thailand Using the Extended Decomposed Theory of Planned Behavior (DTPB) With Self-Directed Learning

This study aimed to explore the determinants of online education adoption based upon the extended Decomposed Theory of Planned Behavior with self-directed learning attributes. Quantitative research method was employed for data collection from a sample of 542 students in Thailand. Data was analyzed using Structural Equation Modeling (SEM). Results showed that all four main variables based on the extended DTPB with self-directed learning were significantly related to adoption intention. However, perceived relative advantage and perceived trialability were found to be insignificantly related to attitude towards online education. Interpersonal influences include peers, family, and the community were found to be significantly related to subjective norms, while superiors’ influence was not. In addition, self-efficacy, technology and resources facilitations were found to be significantly related to perceived behavioral control, and subsequently related to adoption intention towards online education. Surprisingly, more importance was given to factors such as whether online education is personally and socially compatible, simple to use, and seeing other people studying online. Interpersonal referents are influential factors rather than external referents in the students’ decisions, with the exception of more distant relationships with superiors or employers. Findings also indicate that if Thai students are autonomous learners (self-directed learning), have confidence in their capabilities, and have sufficient resources as well as technological facilitations, they are more likely to have intention to adopt online education. This study then provides discussion on both academic and practical implications based on the findings.
Anaphylaxis in children: a 5-year experience.

OBJECTIVES To identify the causative agents, presenting signs and symptoms, and course of disease in children diagnosed with anaphylaxis. Design. Five-year retrospective chart review. SETTING Urban children's hospital pediatric emergency department, operating suite, and inpatient units. PARTICIPANTS Fifty-five cases of anaphylaxis in 50 patients 1 to 19 years of age. INTERVENTIONS None. RESULTS The most common inciting agents in this population were latex (27%), food (25%), drugs (16%), and venoms (15%). Thirty-two cases (58%) occurred outside of the hospital, including 3 of 11 severe cases. Nineteen (35%) had histories of prior allergy to the causative agent. Most agent exposures were intravenous (38%), oral (27%), or dermal (20%). The most common systems involved were respiratory (93%), skin (93%), cardiovascular (26%), and neurologic (26%). Features distinguishing the 11 patients requiring intensive care included latex agents (45%), nonenteral route of exposure (91%), and presence of cardiovascular symptoms (45%). Of the 17 patients with known past anaphylaxis, only 5 had epinephrine self-administration devices available, and 3 had used them. CONCLUSIONS (1) Most patients with anaphylaxis present with skin or respiratory symptoms. (2) Severely ill children more commonly have nonenteral and/or latex exposures that occur in the hospital. (3) Most children with anaphylaxis have no stated histories of prior reaction to the causative agent. (4) Those patients who have had past episodes of anaphylaxis infrequently have epinephrine self-administration devices available for use.
Fourteen Years of Software Engineering at ETH Zurich

A Chair of Software Engineering existed at ETH Zurich, the Swiss Federal Insti-tute of Technology, from 1 October 2001 to 31 January 2016, under my leader-ship. Our work, summarized here, covered a wide range of theoretical and practi-cal topics, with object technology in the Eiffel method as the unifying thread .