Miracle-dz/UniFAR-FTUs huggingface dataset:
Human brain serotonin synthesis capacity measured in vivo with alpha-[C-11]methyl-L-tryptophan.

Local cerebral serotonin synthesis capacity was measured with alpha-[C-11]methyl-L-tryptophan ([C-11]AMT) in normal adult human brain (n = 10; five males, five females; age range, 18-38 years, mean 28.3 years) by using positron emission tomography (PET). [C-11]AMT is an analog of tryptophan, the precursor for serotonin synthesis, and is converted to alpha-[C-11]methyl-serotonin ([C-11]AM-5HT), which is trapped in serotonergic neurons because [C-11]AM-5HT is not degraded by monoamine oxidase. Kinetic analysis of [C-11] activity in brain after injection of [C-11]AMT confirmed the presence of a compartment with unidirectional uptake that represented approximately 40% of the activity in the brain at 50 min after tracer administration. The undirectional rate constant K, which represents the uptake of [C-11]AMT from the plasma to brain tissue followed by the synthesis and physiologic trapping of [C-11]AM-5HT, was calculated using the Patlak graphic approach on a pixel-by-pixel basis, thus creating parametric images. The rank order of K values for different brain regions corresponded well to the regional concentrations of serotonin in human brain (P < .0001). High serotonin synthesis capacity values were measured in putamen, caudate, thalamus, and hippocampus. Among cortical regions, the highest values were measured in the rectal gyrus of the inferior frontal lobe, followed by transverse temporal gyrus; anterior and posterior cingulate gyrus; middle, superior, and inferior temporal gyri; parietal cortex; occipital cortex, in descending order. Values in women were 10-20% higher (P < .05, MANOVA) throughout the brain than those measured in men. Differences in the serotonin synthesis capacity between men and women measured in this study may reflect gender differences of importance to both normal and pathologic behavior. This study demonstrates the suitability of [C-11]AMT as a tracer for PET scanning of serotonin synthesis capacity in human brain and provides normal adult values for future comparison with patient groups.
Expanding Research Capacity at United States Universities: a Study of Academic Research and Development Investment from 1990–2005

Growing emphasis has been placed on universities to contribute to the innovation process and as a result academic research and development expenditures have increased in recent years. Nevertheless, little is known about the specific ways in which universities have expanded their research capacity.This paper examines how universities in the United States (US) have expanded research capacity as research funding has increased. Specifically, it identifies what type of research infrastructure, including various categories of human capital and research equipment, are most closely associated with increased academic research funding. Using data from 375 US universities spanning the period 1990‐2005, through multiple regression analysis this study finds that ‘traditional’and new‘market’based elements of research capacity are associated with increased research funding.The implications of this study extend beyond the US since many countries are both investing in expanding research capacity and transforming the way research is organised within universities.
Targeted Induction of Endoplasmic Reticulum Stress Induces Cartilage Pathology

Pathologies caused by mutations in extracellular matrix proteins are generally considered to result from the synthesis of extracellular matrices that are defective. Mutations in type X collagen cause metaphyseal chondrodysplasia type Schmid (MCDS), a disorder characterised by dwarfism and an expanded growth plate hypertrophic zone. We generated a knock-in mouse model of an MCDS–causing mutation (COL10A1 p.Asn617Lys) to investigate pathogenic mechanisms linking genotype and phenotype. Mice expressing the collagen X mutation had shortened limbs and an expanded hypertrophic zone. Chondrocytes in the hypertrophic zone exhibited endoplasmic reticulum (ER) stress and a robust unfolded protein response (UPR) due to intracellular retention of mutant protein. Hypertrophic chondrocyte differentiation and osteoclast recruitment were significantly reduced indicating that the hypertrophic zone was expanded due to a decreased rate of VEGF–mediated vascular invasion of the growth plate. To test directly the role of ER stress and UPR in generating the MCDS phenotype, we produced transgenic mouse lines that used the collagen X promoter to drive expression of an ER stress–inducing protein (the cog mutant of thyroglobulin) in hypertrophic chondrocytes. The hypertrophic chondrocytes in this mouse exhibited ER stress with a characteristic UPR response. In addition, the hypertrophic zone was expanded, gene expression patterns were disrupted, osteoclast recruitment to the vascular invasion front was reduced, and long bone growth decreased. Our data demonstrate that triggering ER stress per se in hypertrophic chondrocytes is sufficient to induce the essential features of the cartilage pathology associated with MCDS and confirm that ER stress is a central pathogenic factor in the disease mechanism. These findings support the contention that ER stress may play a direct role in the pathogenesis of many connective tissue disorders associated with the expression of mutant extracellular matrix proteins.
Factors associated with the income distribution of full-time physicians: a quantile regression approach.

OBJECTIVE Physician income is generally high, but quite variable; hence, physicians have divergent perspectives regarding health policy initiatives and market reforms that could affect their incomes. We investigated factors underlying the distribution of income within the physician population. DATA SOURCES Full-time physicians (N=10,777) from the restricted version of the 1996-1997 Community Tracking Study Physician Survey (CTS-PS), 1996 Area Resource File, and 1996 health maintenance organization penetration data. STUDY DESIGN We conducted separate analyses for primary care physicians (PCPs) and specialists. We employed least square and quantile regression models to examine factors associated with physician incomes at the mean and at various points of the income distribution, respectively. We accounted for the complex survey design for the CTS-PS data using appropriate weighted procedures and explored endogeneity using an instrumental variables method. PRINCIPAL FINDINGS We detected widespread and subtle effects of many variables on physician incomes at different points (10th, 25th, 75th, and 90th percentiles) in the distribution that were undetected when employing regression estimations focusing on only the means or medians. Our findings show that the effects of managed care penetration are demonstrable at the mean of specialist incomes, but are more pronounced at higher levels. Conversely, a gender gap in earnings occurs at all levels of income of both PCPs and specialists, but is more pronounced at lower income levels. CONCLUSIONS The quantile regression technique offers an analytical tool to evaluate policy effects beyond the means. A longitudinal application of this approach may enable health policy makers to identify winners and losers among segments of the physician workforce and assess how market dynamics and health policy initiatives affect the overall physician income distribution over various time intervals.
COMPRESSIBLE “TURBULENCE” OBSERVED IN THE HELIOSHEATH BY VOYAGER 2

This paper describes the multiscale structure of the compressible “turbulence” observed in the high-resolution (48 s) observations of the magnetic field strength B made by Voyager 2 (V2) in the heliosheath behind the termination shock from 2007 DOY 245.0–300.8 and in a unipolar region from 2008 DOY 2.9–75.6. The magnetic field strength is highly variable on scales from 48 s to several hours in both intervals. The distributions of daily averages and 48 s averages of B are lognormal in the post-termination shock (TS) region and Gaussian in the unipolar region, respectively. The amplitudes of the fluctuations were greater in the post-TS region than in the unipolar region, at scales less than several hours. The multiscale structure of the increments of B is described by the q-Gaussian distribution of nonextensive statistical mechanics on all scales from 48 s to 3.4 hr in the unipolar region and from 48 s to 6.8 hr in the post-TS region, respectively. The amplitudes of the fluctuations of increments of B are larger in the post-TS region than in the unipolar region at all scales. The probability density functions of the increments of B are non-Gaussian at all scales in the unipolar region, but they are Gaussian at the largest scales in the post-TS region. Time series of the magnitude and direction of B show that the fluctuations are highly compressive. The small-scale fluctuations are a mixture of coherent structures (semi-deterministic structures) and random structures, which vary significantly from day to day. Several types of coherent structures were identified in both regions.
Association of Waist-Height Ratio with Diabetes Risk: A 4-Year Longitudinal Retrospective Study

Background Waist-to-height ratio (WHtR) is an easy and inexpensive adiposity index that reflects central obesity. In this study, we examined the association of various baseline adiposity indices, including WHtR, with the development of diabetes over 4 years of follow-up in apparently healthy Korean individuals. Methods A total of 2,900 nondiabetic participants (mean age, 44.3 years; 2,078 men) in a health screening program, who repeated the medical check-up in 2005 and 2009, were recruited. Subjects were divided into two groups according to development of diabetes after 4 years. The cut-off values of baseline body mass index (BMI), waist circumference (WC), and WHtR for the development of diabetes over 4 years were calculated. The sensitivity, specificity, and mean area under the receiver operator characteristic curve (AUROC) of each index were assessed. The odds ratio (OR) for diabetes development was analyzed for each of the three baseline adiposity indices. Results During the follow-up period, 101 new cases (3.5%) of diabetes were diagnosed. The cut-off WHtR value for diabetes development was 0.51. Moreover, WHtR had the highest AUROC value for diabetes development among the three adiposity indices (0.716, 95% confidence interval [CI], 0.669 to 0.763; 0.702, 95% CI, 0.655 to 0.750 for WC; 0.700, 95% CI, 0.651 to 0.750 for BMI). After adjusting for confounding variables, the ORs of WHtR and WC for diabetes development were 1.95 (95% CI, 1.14 to 3.34) and 1.96 (95% CI, 1.10 to 3.49), respectively. No significant differences were observed between the two groups regarding BMI. Conclusion Increased baseline WHtR and WC correlated with the development of diabetes after 4 years. WHtR might be a useful screening measurement to identify individuals at high risk for diabetes.
Racial disparity of epidermal growth factor receptor expression in prostate cancer.

PURPOSE The epidermal growth factor receptor (EGFR) plays a critical role in prostate cancer (PC) signal transduction and is the target of a novel class of anticancer agents. Despite recent reports of interethnic variation in response to EGFR inhibitors, limited information exists regarding differences in expression of EGFR in PC patients. This has therapeutic relevance because a better understanding of the molecular basis underlying the ethnic variability will help in the design of individualized treatment regimens using EGFR inhibitors. PATIENTS AND METHODS We investigated EGFR expression in a well-characterized cohort of PC patients to determine the association between EGFR expression and race. Tumor tissues from 202 radical prostatectomies performed between 1990 and 2000 at the Veterans Administration Medical Center (New York, NY) were studied (142 African Americans, 60 whites; median age, 67 years; stage T2, n = 130; stage > or = T3, n = 72; Gleason score < 7, n = 110; Gleason score > or = 7, n = 92). Membrane-specific EGFR expression was evaluated immunohistochemically. RESULTS EGFR overexpression, defined as complete membrane staining in more than 10% of tumor cells, was observed in 75 of 202 patients (37%). There was a significant association between EGFR overexpression and African American race (P = .0006), higher pretreatment prostate-specific antigen (PSA; P = .02), and stage (P = .02), but not Gleason score (P = .33). The association between African American race and EGFR overexpression remained significant in a multivariate model after controlling for grade, stage, and pretreatment PSA simultaneously (P = .003). CONCLUSION Our data demonstrate that race contributes significantly to variability of EGFR expression in prostate cancer. Racial background may have an impact on the design of clinical trials to test the efficacy of anti-EGFR agents.
The relationship between perceived risk, thought intrusiveness and emotional well‐being in women receiving counselling for breast cancer risk in a family history clinic

Objectives. This study was designed to assess changes in perceived risk, cognitive intrusions and distress in women undergoing counselling for familial risk of developing breast cancer. Design. A longitudinal design in which 90 consecutive women attending a family history clinic were asked to indicate their concerns before counselling and then again 3 and 6 months post-counselling. Method. Questionnaires included measures of thought content and intrusiveness, cancer specific distress (Cockburn, De Luise, Hurley, & Clover, 1992), a Visual Analogue scale (VAS) of perceived risk, and the Hospital Anxiety and Depression (HAD) scale (Zigmond & Snaith, 1983). Results. Sixty-nine women agreed to take part in the study, with 49 completing all three sets of questionnaires. Before counselling, thought intrusiveness and HAD depression scores accounted for 69% of the variance in the measure of cancer specific distress. Women who dropped out of the study before the post-counselling assessments reported higher levels of intrusiveness at baseline than those who completed the study. Perceived risk was only moderately related to actual risk post-counselling and increases/ decreases in thought introsiveness correlated positively with increases/decreases in both perceived risk and distress. Conclusions. Psychological distress is related to levels of perceived risk, a relationship which may be mediated by thought intrusiveness. It could be more appropriate for genetic counselling services to provide strategies for managing intrusiveness of worries rather than attempting to modify risk perceptions.
TOWARDS A THEORY OF SPIRITUALITY IN THE WORKPLACE

In spite of the importance of spirituality and the attention given to it by the media, research on the impact of spirituality in the workplace has been lacking. This paper attempts to stimulate academic interest in the topic by reviewing some of the management and psychology literature on spirituality. The paper takes a few steps towards resolving some of the definitional problems, and advances some preliminary propositions on the relationship between spirituality and job performance and behavior.
Perceived Discrimination, Identification, Social Capital, and Well-Being

This study examined racism, ethnic and majority identification, cognitive aspects of social capital (i.e., a sense of trust), and perceived stress and evaluated the relationships between these variables and two indices of adjustment (physical health, psychological well-being) in three minority ethnic community samples in Scotland, United Kingdom. Pakistani (n = 211, 101 female), Indian (n = 155, 81 female), and African and Caribbean (n = 244, 119 female) individuals participated in semistructured interviews. Racism was associated with higher levels of perceived stress, lower levels of social capital, higher levels of minority identity, and lower levels of majority identity. Racism was also associated with psychological well-being (though in different ways for different groups) and with poorer physical health. Minority identification was positively associated with psychological well-being and negatively with perceived stress, while majority identification was positively associated with social capital and negatively with physical health. Implications of these findings are discussed with reference to the literature.
Experimental Incubations Elicit Profound Changes in Community Transcription in OMZ Bacterioplankton

Sequencing of microbial community RNA (metatranscriptome) is a useful approach for assessing gene expression in microorganisms from the natural environment. This method has revealed transcriptional patterns in situ, but can also be used to detect transcriptional cascades in microcosms following experimental perturbation. Unambiguously identifying differential transcription between control and experimental treatments requires constraining effects that are simply due to sampling and bottle enclosure. These effects remain largely uncharacterized for “challenging” microbial samples, such as those from anoxic regions that require special handling to maintain in situ conditions. Here, we demonstrate substantial changes in microbial transcription induced by sample collection and incubation in experimental bioreactors. Microbial communities were sampled from the water column of a marine oxygen minimum zone by a pump system that introduced minimal oxygen contamination and subsequently incubated in bioreactors under near in situ oxygen and temperature conditions. Relative to the source water, experimental samples became dominated by transcripts suggestive of cell stress, including chaperone, protease, and RNA degradation genes from diverse taxa, with strong representation from SAR11-like alphaproteobacteria. In tandem, transcripts matching facultative anaerobic gammaproteobacteria of the Alteromonadales (e.g., Colwellia) increased 4–13 fold up to 43% of coding transcripts, and encoded a diverse gene set suggestive of protein synthesis and cell growth. We interpret these patterns as taxon-specific responses to combined environmental changes in the bioreactors, including shifts in substrate or oxygen availability, and minor temperature and pressure changes during sampling with the pump system. Whether such changes confound analysis of transcriptional patterns may vary based on the design of the experiment, the taxonomic composition of the source community, and on the metabolic linkages between community members. These data highlight the impressive capacity for transcriptional changes within complex microbial communities, underscoring the need for caution when inferring in situ metabolism based on transcript abundances in experimental incubations.
Investigating the role of psychoticism and sensation seeking in predicting emotional reactions to music

Recent studies have examined reactions to music within the framework of the circumplex model of emotion. The present study employed questionnaire measures of psychoticism (P) and impulsive sensation seeking (ISS) to explore the relationship between personality and reactions to music selected to produce the emotions in the quadrants of the circumplex. The 65 female and 27 male undergraduate students listened to four excerpts of music representing each of the four quadrants, with music in each quadrant selected to reflect classical/contemporary and familiar/unfamiliar distinctions. Participants rated each excerpt with respect to liking, familiarity, pleasantness and arousal potential, and on seven pairs of emotion-related adjectives. P was associated with the tendency to enjoy music that was unsettling and boring: that is, in the `unpleasant' half of the circumplex. P was also linked with negative emotional responses to music that was relaxing and exciting: that is, in the `pleasant' half of the circumplex. There were few significant correlations with ISS, although high scorers reported being sadder, and less happy, than low scorers when listening to relaxing/peaceful music. The results provided general support to previous studies relating psychoticism to liking for music sometimes characterized as `problem' or `deviant'.
Periodontoloji kliniğine başvuran hastalarda periodontal durum ve sistemik hastalıkların değerlendirilmesi

Objectives: The present study aims to determine the periodontal status and frequencies of the systemic diseases encountered in individuals admitted to Periodontology Department of Faculty of Dentistry at Cumhuriyet University. Materials and Methods: The present study included 1400 individuals aged between 12-82, 834 of whom were female, and 566 of whom were male. The factors investigated were periodontal status, oral hygiene habits, smoking and presence of systemic diseases. Clinical and radiological examinations were utilized in the diagnosis of periodontal disease. Results: When periodontal conditions were investigated, it was found that 0.3% of the patients were healthy, 51.9% had gingivitis, 46,4% had chronic periodontitis and 1.4% had aggressive periodontitis. The prevalence of systemic diseases in the sample group of the study was 39.2%. 31.4 % of the patients with gingivitis, 47.9% of the patients with chronic periodontitis and 50% of the patients with aggressive periodontitis were also found to have systemic disease. 2.1% of the patients included in the study had hepatitis and 24.4% were smokers. Conclusions: The prevalence of periodontal and systemic diseases in the sample group of the study was found to be high. A detailed medical history of all patients with periodontal disease should be obtained and investigated and an appropriate treatment should be planned accordingly. OZET Amac: Bu calismada, Cumhuriyet Universitesi Dis hekimligi Fakultesi Periodontoloji Anabilim Dalina basvuran bireylerin periodontal durumlarinin ve bu hastalarda karsilasilan sistemik hastaliklarin sikliklarinin belirlenmesi amaclandi. Gerec ve Yontem: 834 kadin, 566 erkek 12-82 yas arasindaki 1400 birey calismaya dahil edildi. Periodontal durum, oral hijyen aliskanliklari, sigara aliskanligi ve sistemik hastalik varligi arastirildi. Klinik ve radyolojik muayene sonrasi periodontal hastalik teshisi konuldu. Bulgular: Periodontal durumlarina gore hastalarin %0,3 periodontal acidan saglikli, %51.9’u gingivitis, %46,4 kronik periodontitis, %1,4 agresif periodontitis olarak saptandi. Calismadaki bireylerin sistemik hastalik prevalansi %39.2 olarak tespit edildi. Gingivitis tanisi olan hastalarin %31,4’de, kronik periodontitisli hastalarin %47,9 ve agresif periodontitisli hastalarin %50'sinde sistemik hastalik gozlendi. Bu calismaya katilan bireylerin %2,1’nin hepatit oldugu ve %24,4’nun sigara ictigi tespit edildi. Sonuclar: Bu calisma, periodontal ve sistemik hastaliklarin gorulme sikliginin incelenen bireyler arasinda yuksek oldugunu gosterdi. Periodontal hastaligi bulunan tum bireylerden tedavi oncesi detayli anamnez alinmali, buna gore uygun tedavi planlanmalidir. Anahtar Kelimeler: Periodontal hastalik, tibbi oyku, sistemik hastalik.