Miracle-dz/UniFAR-FTUs huggingface dataset:
Employer Voices, Employer Demands, and Implications for Public Skills Development Policy

Educators believe that they are adequately preparing youth for the labor market while employers lament the lack of skills. A possible source of the mismatch in perceptions is that employers and educators have different understandings of the types of skills valued in the labor market. This paper uses economics and psychology literature to define four skills sets: socio-emotional, higher-order cognitive, basic cognitive, and technical skills. The paper reviews the literature that quantitatively measures employer skill demand, as reported in preference surveys. A sample of 28 studies reveals remarkable consistency across the world in the skills demanded by employers. Although employers value all skill sets, there is a greater demand for socio-emotional and higher-order cognitive skills than for basic cognitive or technical skills. These results are robust across economy size and level of development, sector, export-orientation, and occupations. Employers perceive that the greatest skills gaps are in socio-emotional and technical skills. These findings suggest the need to re-conceptualize education and training systems. Taking into consideration the developmental process to acquire the skills identified by employers, this implies the need to recognize that (a) the job-skills development process necessarily begins at birth and continues throughout the life cycle so skills policy should, as well; (b) schools play a relevant, but limited, role in skills development and the role of parents, mentors, and the work place must be defined and enhanced; and (c) the skills most demanded by employers -- higher-order cognitive and socio-emotional skills -- are largely taught (the former) or refined in secondary school, which argues for a general education until these skills are formed.
p53 codon 72 polymorphism and Hematological Cancer Risk: An Update Meta-Analysis

Background Previous studies on the association of p53 codon 72 (Arg72Pro) polymorphism with hematological malignancies risk have produced conflicting results. The purpose of this meta-analysis is to define the effect of p53 Arg72Pro polymorphism on hematological malignancies risk. Methodology/Principal Findings Through searching PubMed databases (or hand searching) up to April 2012 using the following MeSH terms and keywords: “p53”, “codon 72” “polymorphism” and “leukemia”, or “lymphoma”, or “myeloma”, thirteen were identified as eligible articles in this meta-analysis for p53 Arg72Pro polymorphism (2,731 cases and 7, 356 controls), including nine studies on leukemia (1,266 cases and 4, 474 controls), three studies on lymphoma (1,359 cases and 2,652 controls), and one study on myeloma. The overall results suggested that p53 Arg72Pro polymorphism was not associated with hematological malignancies risk. In stratified analyses, significantly increased non-Hodgkin lymphomas risk was found in p53 Arg72Pro polymorphism heterozygote model (Arg/Pro vs. Arg/Arg: OR = 1.18, 95%CI: 1.02–1.35) and dominant model (Arg/Pro+Pro/Pro vs. Arg/Arg: OR = 1.18, 95%CI: 1.03–1.34), but no significant association was found between leukemia risk and p53 Arg72Pro polymorphism. Further studies showed no association between leukemia risk and p53 Arg72Pro polymorphism when stratified in subtypes of leukemias, ethnicities and sources of controls. Conclusions/Significance This meta-analysis indicates that the p53 Arg72Pro polymorphism may contribute to susceptibility to non-Hodgkin lymphomas.
Gaining control: trends in the processes of change for video lottery terminal gamblers

This study examined the processes of change used by problem gamblers in the action and maintenance stages of the Transtheoretical Model of Change (TTM) as proposed in the research by Prochaska and DiClemente. A sample of 25 problem gamblers in the action stage and 38 in the maintenance stage were compared in terms of usage of three of these processes (counterconditioning, stimulus control and reinforcement management). Two mediating variables, self-efficacy and situational temptation, were also assessed. As hypothesised, the usage of counterconditioning and stimulus control declined significantly between the action and maintenance stages. No change was found in reinforcement management between the stages. Self-efficacy increased and situational temptation declined between the action and maintenance stages. Problem gamblers made significant use of these processes suggesting the TTM model is applicable to problem gambling. The discussion focuses on possible regulatory and venue operator actions that might help the problem gambler utilise these processes in the natural recovery process.
First Months in Teaching—Novices Relate to Their Difficulties

The study aimed to identify the main hardships and challenges encountered by teaching interns and the ways in which they cope with these difficulties, as they emerged from personal diaries that the interns kept in the first year of teaching. Findings from the diaries identified the following main categories of hardship on entering the profession: 1) difficulties in the personal dimension, including difficulties involved in navigating between private and professional lives; 2) difficulties in the personal-professional dimension relating to the transition from the status of student to the status of internship; 3) difficulties in the inter-personal dimension including communication with colleagues and parents and a sense of isolation; 4) difficulties in the professional dimension including coping with the complexity of teaching, handling a class and burdensome workloads. The findings also relate to coping strategies employed by the interns to cope with these difficulties. Early pre-service teaching including exposure to the difficulties involved in teaching may facilitate initial work experiences, lessen the shock of the first plunge into the classroom and reduce the phenomenon of early dropout from the profession.
A Cluster of Nucleotide‐Binding Site–Leucine‐Rich Repeat Genes Resides in a Barley Powdery Mildew Resistance Quantitative Trait Loci on 7HL

Powdery mildew causes severe yield losses in barley production worldwide. Although many resistance genes have been described, only a few have already been cloned. A strong QTL (quantitative trait locus) conferring resistance to a wide array of powdery mildew isolates was identified in a Spanish barley landrace on the long arm of chromosome 7H. Previous studies narrowed down the QTL position, but were unable to identify candidate genes or physically locate the resistance. In this study, the exome of three recombinant lines from a high‐resolution mapping population was sequenced and analyzed, narrowing the position of the resistance down to a single physical contig. Closer inspection of the region revealed a cluster of closely related NBS‐LRR (nucleotide‐binding site–leucine‐rich repeat containing protein) genes. Large differences were found between the resistant lines and the reference genome of cultivar Morex, in the form of PAV (presence‐absence variation) in the composition of the NBS‐LRR cluster. Finally, a template‐guided assembly was performed and subsequent expression analysis revealed that one of the new assembled candidate genes is transcribed. In summary, the results suggest that NBS‐LRR genes, absent from the reference and the susceptible genotypes, could be functional and responsible for the powdery mildew resistance. The procedure followed is an example of the use of NGS (next‐generation sequencing) tools to tackle the challenges of gene cloning when the target gene is absent from the reference genome.
Ras/ERK signaling pathway is involved in curcumin-induced cell cycle arrest and apoptosis in human gastric carcinoma AGS cells

Curcumin, the biologically active compound from the rhizome of Curcuma longa, could inhibit cell growth and induce apoptosis in gastric carcinoma. However, the underlying mechanism of curcumin on gastric carcinoma cells still needs further investigation. In this study, morphological observation indicated that curcumin inhibited the proliferation of AGS cells in a dose-dependent manner. According to the flow cytometric analysis, curcumin treatment resulted in G2/M arrest in AGS cells, accompanied with an increased expression of cyclin B1 and a decreased expression of cyclin D1. In addition, DNA ladders were observed by gel electrophoresis. Meanwhile, the activities of caspase-3, -8, and -9 were also enhanced in curcumin-treated AGS cells. Nevertheless, the increased activities could be inhibited by benzyloxycarbonyl-Val-Ala-Asp (OME)-fluoromethylketone (z-VAD-fmk), which suggested that the apoptosis was caspase-dependent. Furthermore, downregulation of rat sarcoma (Ras) and upregulation of extracellular-signal-regulated kinase (ERK) were also observed in AGS cells treated with curcumin by Western blot. U0126, an ERK inhibitor, blocked curcumin-induced apoptosis. The results suggested that curcumin inhibited the growth of the AGS cells and induced apoptosis through the activation of Ras/ERK signaling pathway and downstream caspase cascade, and curcumin might be a potential target for the treatment of gastric carcinoma.
Comparison of temperature distribution in FinFETs and GAAFETs based on Dual-Phase-Lag heat transfer model

In this paper the comparison of the temperature distribution in nanosized FinFET and Gate-All-Around FET (GAAFET) structures is presented. Two different heat transfer models are taken into considerations. The first one is the classical Fourier-Kirchhoff model, while the second one is called the Dual-Phase-Lag model. The thermal analyses include the comparison of the transient and steady-state temperatures inside the FinFET and GAAFET channels. In order to make the analysis more convenient, the normalization of the temperature values have been introduced. All thermal parameter values have been taken from the specialist literature.
Health care agreements as a tool for coordinating health and social services

Introduction In 2007, a substantial reform changed the administrative boundaries of the Danish health care system and introduced health care agreements to be signed between municipal and regional authorities. To assess the health care agreements as a tool for coordinating health and social services, a survey was conducted before (2005–2006) and after the reform (2011). Theory and methods The study was designed on the basis of a modified version of Alter and Hage's framework for conceptualising coordination. Both surveys addressed all municipal level units (n = 271/98) and a random sample of general practitioners (n = 700/853). Results The health care agreements were considered more useful for coordinating care than the previous health plans. The power relationship between the regional and municipal authorities in drawing up the agreements was described as more equal. Familiarity with the agreements among general practitioners was higher, as was the perceived influence of the health care agreements on their work. Discussion Health care agreements with specific content and with regular follow-up and systematic mechanisms for organising feedback between collaborative partners exemplify a useful tool for the coordination of health and social services. Conclusion There are substantial improvements with the new health agreements in terms of formalising a better coordination of the health care system.
High-Content Screening with siRNA Optimizes a Cell Biological Approach to Drug Discovery: Defining the Role of P53 Activation in the Cellular Response to Anticancer Drugs

Deciphering the effects of compounds on molecular events within living cells is becoming an increasingly important component of drug discovery. In a model application of the industrial drug discovery process, the authors profiled a panel of 22 compounds using hierarchical cluster analysis of multiparameter high-content screening measurements from nearly 500,000 cells per microplate. RNAi protein knockdown methodology was used with high-content screening to dissect the effects of 2 anticancer drugs on multiple target activities. Camptothecin activated p53 in A549 lung carcinoma cells pretreated with scrambled siRNA, exhibited concentration-dependent cell cycle blocks, and induced moderate microtubule stabilization. Knockdown of camptothecin-induced p53 protein expression with p53 siRNA inhibited the G1/S blocking activity of the drug and diminished its microtubule-stabilizing activity. Paclitaxel activated p53 protein at low concentrations but exhibited G2/M cell cycle blocking activity at higher concentrations where microtubules were stabilized. In cells treated with p53 siRNA, paclitaxel failed to activate p53 protein, but the knockdown did not have a significant effect on the ability of paclitaxel to stabilize microtubules or induce a G2/M cell cycle block. Thus, this model application of the use of RNAi technology within the context of high-content screening shows the potential to provide massive amounts of combinatorial cell biological information on the temporal and spatial responses that cells mount to treatment by promising therapeutic candidates.
Microsatellite and morphological analysis of population structure in the parthenogenetic freshwater snail Melanoides tuberculata: insights into the creation of clonal variability

The distribution of variability was studied at various geographical scales in the tropical freshwater snail Melanoides tuberculata, in order to analyse the role of factors shaping this distribution, including the mating system and population dynamics. This parthenogenetic polyploid species reproduces mainly asexually, with males occurring at low frequency. About 800 individuals (38 sites) were sampled from Africa and the Middle East, where the species originated, and from recently colonized habitats in South and Central America, and especially the island of Martinique. We first described variation of general aspects and ornamentation of the shells. This analysis confirms the existence of discrete morphs. Second, individuals were studied at three microsatellite loci, showing that each morph is a genetic clone with some minor variation compatible with models of microsatellite evolution. The genetic analysis also showed much more variation within than between clones. However, two populations from Africa exhibited a large amount of variability, and a mixture of sexual and asexual reproduction might explain these genetic patterns. The worldwide distribution of variability is, therefore, compatible with the African origin of the species, and the introduction of a few clones in other parts of the world. These results also suggest that the distribution of variability in Martinique is influenced by flooding events, and that two morphs from Martinique can be interpreted as hybrids between two pre‐existing morphs, based on morphological, genetic and geographical arguments.
Digoxin reveals a functional connection between HIV-1 integration preference and T-cell activation

HIV-1 integrates more frequently into transcribed genes, however the biological significance of HIV-1 integration targeting has remained elusive. Using a selective high-throughput chemical screen, we discovered that the cardiac glycoside digoxin inhibits wild-type HIV-1 infection more potently than HIV-1 bearing a single point mutation (N74D) in the capsid protein. We confirmed that digoxin repressed viral gene expression by targeting the cellular Na+/K+ ATPase, but this did not explain its selectivity. Parallel RNAseq and integration mapping in infected cells demonstrated that digoxin inhibited expression of genes involved in T-cell activation and cell metabolism. Analysis of >400,000 unique integration sites showed that WT virus integrated more frequently than N74D mutant within or near genes susceptible to repression by digoxin and involved in T-cell activation and cell metabolism. Two main gene networks down-regulated by the drug were CD40L and CD38. Blocking CD40L by neutralizing antibodies selectively inhibited WT virus infection, phenocopying digoxin. Thus the selectivity of digoxin depends on a combination of integration targeting and repression of specific gene networks. The drug unmasked a functional connection between HIV-1 integration and T-cell activation. Our results suggest that HIV-1 evolved integration site selection to couple its early gene expression with the status of target CD4+ T-cells, which may affect latency and viral reactivation.
Near-Infrared Surface Properties of the Two Intrinsically Brightest Minor Planets: (90377) Sedna and (90482) Orcus

We present low-resolution K-band spectra taken at the Gemini 8 m telescope of (90377) Sedna and (90482) Orcus (provisional designations 2003 VB12 and 2004 DW, respectively), currently the two minor planets with the greatest absolute magnitudes (i.e., the two most reflective minor planets). We place crude limits on the surface composition of these two bodies using a Hapke model for a wide variety of assumed albedos. The unusual minor planet Sedna was discovered on UT 2003 November 14 at roughly 90 AU, with 1.6 times the heliocentric and perihelion distances of any other bound minor planet. It is the first solar system object discovered between the Kuiper Belt and the Oort Cloud and may represent a transition population between the two. The reflectance spectrum of Sedna appears largely featureless at the current signal-to-noise ratio, suggesting a surface likely to be highly processed by cosmic rays. For large-grain models (100 μm to 1 cm) we find that Sedna cannot have more than 70% surface coverage of water ice and cannot have more than 60% surface coverage of methane ice, to 3 σ confidence. Minor planet Orcus shows strong water ice absorption corresponding to less than a 50% surface fraction for grain models 25 μm and larger. Orcus cannot have more than 30% of its surface covered by large (100 mm to 1 cm) methane grains, to 3 σ confidence.
In vitro anthelmintic activity of crude extracts of selected medicinal plants against Haemonchus contortus from sheep

Abstract Ethanol extracts of 25 plant species were screened for anthelmintic effects against Haemonchus contortus. Ethanol extracts of each plant were used at various concentrations (10, 20 and 30%) to treat 10-day faecal cultures, incubated at 27°C with control cultures which were treated with ethanol for 48 h. Five plants with high efficacies (Ananas comosus, Aloe ferox, Allium sativum, Lespedeza cuneata and Warburgia salutaris) were selected from the first screening for further investigation using ethanol, dichloromethane and water extracts at four concentrations (2.5, 5, 10 and 20%). Ethanol was the most effective solvent. Larval counts decreased with increasing extract concentrations, of which 10 and 20% had similar effects. Lespedeza cuneata caused more than 70% mortality at all concentrations. However, there remains a need to assess in vivo efficacy of these plants.
Leukocyte-Rich Platelet-Rich Plasma Injections Do Not Up-Modulate Intra-Articular Pro-Inflammatory Cytokines in the Osteoarthritic Knee

Introduction The presence of leukocytes in platelet concentrates is deemed to cause deleterious effects when injected intra articularly. The aim of this study is to analyse both local and systemic effects induced by leukocyte-rich Platelet-rich Plasma (PRP) injections through a proteomic characterization of serial synovial fluid and blood samples obtained from subjects treated for knee OA. Secondary aim was to compare the effects on knee homeostasis and systemic response with those obtained with visco-supplementation. Methods Thirty-six OA patients treated either by autologous L-PRP or HA intra-articular knee injections, administered in series of three at one-week intervals, were analyzed. Just before the injection, 1 ml of synovial fluid was collected through the same needle way. In the same time, a peripheral blood sample was obtained and plasma separated. A further peripheral blood sample was collected at 2, 6, and 12 months. L-PRP, plasma and synovial fluid were tested by multiplex bead-based sandwich immunoassay by means of the Bio-Plex suspension array system (Bio-Rad Laboratories) for the presence of pro- and anti-inflammatory cytokines (IL-1beta, IL-6, IL-8, IL-17 and IL-4, IL-10, IL-13) and growth factors (FGF-b, HGF, PDGF-AB/BB). Results In general, pro-inflammatory cytokine levels were similar at basal condition and after treatment whereas anti-inflammatory ones were nearly undetectable. L-PRP administration did not modulate significant changes of cytokine concentrations either in synovial fluid or plasma, whatever the time points analyzed. No different trend was observed between L-PRP and HA administration in terms of pro- and anti-inflammatory cytokines, as well as growth factors. Conclusions In contrast with the evidence reported by “in vitro” studies, where a cellular pro-inflammatory response appears to be induced by the presence of leukocytes, these results suggest that the presence leukocyte-rich PRP doesn’t induce a relevant in vivo up regulation of pro-inflammatory mediators.
Collateral Consequences and Community Re-Entry for Registered Sex Offenders with Child Victims: Are the Challenges Even Greater?

Abstract Sex offender registries are designed to enhance public safety (especially for children) by making community members aware of the identities and residential locations of convicted sex offenders in their neighborhoods. An emerging body of literature shows that registered sex offenders experience difficulties finding employment, housing, and generally reintegrating back into the community, all of which may have significant negative impacts on successful (and law-abiding) re-entry. To date the literature has not specifically assessed if and how collateral consequences and re-entry challenges may be more severe for sex offenders who victimize children. Drawing on data from registered sex offenders in five urban counties the present research finds that sex offenders who victimize children do not experience greater residential disadvantage than their adult-targeting counterparts. Therefore, issues of re-entry, reintegration and facilitators of rehabilitative efforts may not be more difficult or significant for sex offenders who victimize children.
“What Is Your Evidence?” A Study of Controversial Topics on Social Media

In recent years, social media has revolutio n-ized how people communicate and share i n-formation. On e function of social media, b e-sides connecting with friends, is sharing opi n-ions with others. Micro blogging sites , like Twitter , ha ve often provided an online forum for social activism. When users debat e about controversial topics on social media , they ty p-ically share different types of evidence to support their claim s . C lassif ying these types of evidence can provide an estimate for how adequately the arguments have been suppor t-ed. We first introduce a manually built gold standard dataset of 3000 tweets related to the recent FBI and Apple encryption debate. We develop a framework for automatically class i-fying six evidence types typically used o n Twitter to discu ss the debate. Our findings show that a Support Vector Machine (SVM) classifier trained with n - gram and additional features is capable of capturing the different forms of represent ing evidence o n Twitter , and exhibit s significant improvements over the unig ram baseline, achieving a F 1 ma cro - averaged of 82.8%.