Miracle-dz/UniFAR-FTUs huggingface dataset:
Free vibration analysis of multilayered composite and soft core sandwich plates resting on Winkler–Pasternak foundations

Free vibration of laminated composite and soft core sandwich plates resting on Winkler–Pasternak foundations using four-variable refined plate theory are presented. The theory accounts for the hyperbolic distribution of the transverse shear strains through the plate thickness, and satisfies the zero traction boundary conditions on the surfaces of the plate without using shear correction factors. Equations of motion are derived from the dynamic version of the principle of virtual work. Navier technique is employed to obtain the closed-form solutions of antisymmetric cross-ply, angle-ply, and soft core laminates or soft core sandwich plates resting on elastic foundations. Numerical results obtained using present theory are compared with three-dimensional elasticity solutions and those computed using the first-order and the other higher-order theories. It can be concluded that the proposed theory is not only accurate, but also efficient in predicting the natural frequencies of laminated composite and soft core sandwich plates resting on Winkler–Pasternak foundations.
Coherent imaging of an attosecond electron wave packet

Attosecond pulses image the quantum mechanical nodal structure as an electron is expelled from a neon atom. A detailed look at an electron's exit When a burst of light ejects an electron from an atom, the later detection of two charged particles masks a great deal of intermittent quantum mechanical complexity. Villeneuve et al. provide a striking look at the wavelike properties of the electron just as it emerges from neon, expelled by two photons from an attosecond pulse train in a strong infrared field. The phase distribution displays the characteristic three-node structure of an f-wave, which the Stark shift from the strong field appears to select with a single magnetic quantum number of 0. Science, this issue p. 1150 Electrons detached from atoms or molecules by photoionization carry information about the quantum state from which they originate, as well as the continuum states into which they are released. Generally, the photoelectron momentum distribution is composed of a coherent sum of angular momentum components, each with an amplitude and phase. Here we show, by using photoionization of neon, that a train of attosecond pulses synchronized with an infrared laser field can be used to disentangle these angular momentum components. Two-color, two-photon ionization via a Stark-shifted intermediate state creates an almost pure f-wave with a magnetic quantum number of zero. Interference of the f-wave with a spherically symmetric s-wave provides a holographic reference that enables phase-resolved imaging of the f-wave.
Acute impact of drinking coffee on the cerebral and systemic vasculature

Previous studies have suggested that the risk of ischemic stroke increases immediately after drinking coffee. Indeed, drinking coffee, that is, caffeine, acutely increases arterial stiffness as well as blood pressure and peripheral vascular resistance. On the other hand, it has been reported that arterial stiffening is associated with elevation in the pulsatility index (PI) of cerebral blood flow (CBF), which increases the risk of brain disease. However, the effect of drinking coffee on the PI of the CBF and its interaction with arterial stiffness remain unknown. Against this background, we hypothesized that an acute increase in arterial stiffness induced by drinking coffee augments cerebral pulsatile stress. To test this hypothesis, in 10 healthy young men we examined the effects of drinking coffee on the PI of middle cerebral artery blood velocity (MCAv) and brachial‐ankle pulse wave velocity (baPWV) as indices of cerebral pulsatile stress and arterial stiffness, respectively. Mean arterial blood pressure and baPWV were higher (P < 0.01 and P = 0.02), whereas mean MCAV and mean cerebrovascular conductance index were lower upon drinking coffee (P = 0.02 and P < 0.01) compared with a placebo (decaffeinated coffee). However, there was no difference in the PI of MCAv between drinking coffee and the placebo condition. These findings suggest that drinking coffee does not increase cerebral pulsatile stress acutely despite an elevation in arterial stiffness in the systemic circulation.
Exploring Dutch surgeons’ views on volume-based policies: a qualitative interview study

Objective In many countries, the evidence for volume–outcome associations in surgery has been transferred into policy. Despite the large body of research that exists on the topic, qualitative studies aimed at surgeons’ views on, and experiences with, these volume-based policies are lacking. We interviewed Dutch surgeons to gain more insight into the implications of volume–outcome policies for daily clinical practice, as input for effective surgical quality improvement. Methods Semi-structured interviews were conducted with 20 purposively selected surgeons from a stratified sample for hospital type and speciality. The interviews were recorded, transcribed verbatim and underwent inductive content analysis. Results Two overarching themes were inductively derived from the data: (1) minimum volume standards and (2) implications of volume-based policies. Although surgeons acknowledged the premise ‘more is better’, they were critical about the validity and underlying evidence for minimum volume standards. Patients often inquire about caseload, which is met with both understanding and discomfort. Surgeons offered many examples of controversies surrounding the process of determining thresholds as well as the ways in which health insurers use volume as a purchasing criterion. Furthermore, being held accountable for caseload may trigger undesired strategic behaviour, such as unwarranted operations. Volume-based policies also have implications for the survival of low-volume providers and affect patient travel times, although the latter is not necessarily problematic in the Dutch context. Conclusions Surgeons in this study acknowledged that more volume leads to better quality. However, validity issues, undesired strategic behaviour and the ways in which minimum volume standards are established and applied have made surgeons critical of current policy practice. These findings suggest that volume remains a controversial quality measure and causes polarization that is not conducive to a collective effort for quality improvement. We recommend enforcing thresholds that are based on the best achievable level of consensus and assessing additional criteria when passing judgement on quality of care.
Understanding the nature of online emotional experiences: a study of enjoyment as a web experience

Have you ever felt frustrated, annoyed or even enraged when interacting online with one service provider, but thoroughly enjoyed your experiences with another? Do you find some websites not only easier to use, but more enjoyable too? Online service providers now need to think beyond basic concepts of functionality and ease-of-use and consider the emotional experiences that their services engender. This paper indicates a new fundamental direction for research that links online service design with emotional experiences. It is necessary to connect information systems (IS) research with psychology, philosophy, and even physiology and neuroscience to take advantage of the rapid advances in these fields. One positive online emotional experience, namely enjoyment, was selected as the research theme. Three studies with seven websites were conducted. The research is significant as it shows how assessment of a complex emotion can deepen understanding of online service provision and go beyond attention to functional needs. Subsequent innovations in services have high potential benefit in terms of productivity gains, increased exports and more satisfied clients in the community.
Numerical abilities in Williams syndrome: Dissociating the analogue magnitude system and verbal retrieval

Two numerical systems—the analogue magnitude system and verbal retrieval—were investigated in Williams syndrome (WS) with three numerical tasks: simple addition, simple multiplication, and number comparison. A new matching technique was introduced in selecting the proper control groups. The WS group was relatively fast in the addition and multiplication tasks, but was slow in number comparison. No reverse numerical effect was observed in the comparison task, and the distance effect was stronger than that in the control groups. The findings indicate a profile with an impaired analogue magnitude system and less impaired verbal retrieval in Williams syndrome.
Shaping of ceramic parts by selective laser melting of powder bed

Laser additive manufacturing allows the production of polymeric or metallic parts with complex shapes. A major advantage of this contactless technology is that it allows reaching very high energy densities with an excellent precision in short times. This is very suitable for processing hard refractory metals for instance. Unfortunately, current results are less satisfactory for ceramics as a consequence of their intrinsic properties such as a low thermal shock resistance and very high refractoriness. Another significant limitation is related to the poor absorptivity of oxide ceramics in the near-infrared region which is typical for most commercial selective laser melting (SLM) machines. This study considers an alternative to overcome the above-mentioned limitations, especially the lack of absorptivity. SLM of oxide ceramics has become possible. Large parts with complex shapes and relative densities up to 90% have been manufactured on a commercial SLM machine.
Gestational Outcome in Thrombophilic Women with Recurrent Pregnancy Loss Treated by Enoxaparin

Summary Inherited and acquired thrombophilia are associated with recurrent pregnancy loss (RPL). We have evaluated the efficacy and safety of the low molecular weight heparin enoxaparin in 50 women, (mean age 26 ± 3 years) with RPL (>3 losses in 1st, >2 losses in 2nd and >1 loss in 3rd trimester) who were found to harbor thrombophilia. Twentyseven had a solitary thrombophilic defect, and twenty-three women had combined thrombophilic defects: 17 – two defects and 6 – three defects. Following diagnosis of thrombophilia, sixty-one subsequent pregnancies were treated with the low molecular weight heparin enoxaparin throughout gestation until 4 weeks after delivery. Dosage was 40 mg/day in women with solitary defect and 80 mg/day in combined defects. Aspirin, 75 mg daily was given in addition to enoxaparin to women with antiphospholipid syndrome. Forty-six out of 61 (75%) gestations treated by enoxaparin resulted in live birth compared to only 38/193 (20%) of the untreated pregnancies in these 50 women prior to diagnosis of thrombophilia (p <0.00001). In 23 women without a single living child following 82 untreated gestations, antithrombotic therapy resulted in 26/31 (84%) successful deliveries (p <0.0001). In 20 women with a prior living child, antithrombotic therapy improved successful delivery from 33/86 (38%) to 20/21 (95%) (p <0.0001). Enoxaparin dose of 40 mg/day resulted in live birth in 24/35 (69%) of gestations, compared to 19/23 (83%) gestations in women treated with 80 mg/day (p = 0.37). Only one thrombotic episode and one mildbleeding episode were noticed during enoxaparin therapy. Enoxaparin is safe and effective in prevention of pregnancy loss in women with inherited and acquired thrombophilia.
Effects of n-3 long-chain PUFA supplementation to lactating mothers and their breastfed children on child growth and morbidity: a 2 × 2 factorial randomized controlled trial in rural Ethiopia.

Background Recurrent infections and inflammation contribute to growth faltering in low-income countries. n-3 (ω-3) Long-chain polyunsaturated fatty-acids (LC-PUFAs) may improve immune maturation, resistance to infections, and growth in young children who are at risk. Objective We evaluated the independent and combined effects of fish oil (500 mg n-3 LC-PUFAs/d) supplementation to lactating mothers and their breastfed children, aged 6-24 mo, on child morbidity, systemic inflammation, and growth in southwest Ethiopia. Design A 4-arm double-blind randomized controlled trial was conducted by enrolling 360 mother-infant pairs with infants 6-12 mo old. Study arms were both the lactating mother and child receiving fish oil intervention (MCI), only the lactating mother receiving fish oil intervention and child receiving placebo control (MI), only the child receiving intervention and mother receiving placebo control (CI), and both mother and child receiving a placebo supplement or control (C). The primary study outcome was linear growth using monthly changes in length-for-age z score. Anthropometric measurements were taken monthly, and hemoglobin, C-reactive protein, and blood LC-PUFAs were measured at baseline and after 6 and 12 mo of follow-up. Weekly morbidity surveillance was conducted throughout the study. Results Fish-oil supplementation significantly increased blood n-3 LC-PUFA concentration (P < 0.01) and decreased the arachidonic acid:(docosahexaenoic acid + eicosapentaenoic acid) ratio (P < 0.001) in all intervention arms. No significant intervention effect was found on linear growth, morbidity, or systemic inflammation. Compared to the control group, a small positive effect on monthly changes in weight-for-length z scores was found in the CI arm (effect size: 0.022/mo; 95% CI: 0.005, 0.039/mo; P = 0.012) and the MCI arm (effect size: 0.018/mo; 95% CI: 0.001, 0.034/mo; P = 0.041). Conclusions n-3 LC-PUFA supplementation of lactating mothers and children did not affect child linear growth and morbidity in a low-income setting. n-3 LC-PUFA supplementation given directly to children modestly increased relative weight gain. This trial was registered at clinicaltrials.gov as NCT01817634.
Shear-Thinning Nanocomposite Hydrogels for the Treatment of Hemorrhage

Internal hemorrhaging is a leading cause of death after traumatic injury on the battlefield. Although several surgical approaches such as the use of fibrin glue and tissue adhesive have been commercialized to achieve hemostasis, these approaches are difficult to employ on the battlefield and cannot be used for incompressible wounds. Here, we present shear-thinning nanocomposite hydrogels composed of synthetic silicate nanoplatelets and gelatin as injectable hemostatic agents. These materials are demonstrated to decrease in vitro blood clotting times by 77%, and to form stable clot-gel systems. In vivo tests indicated that the nanocomposites are biocompatible and capable of promoting hemostasis in an otherwise lethal liver laceration. The combination of injectability, rapid mechanical recovery, physiological stability, and the ability to promote coagulation result in a hemostat for treating incompressible wounds in out-of-hospital, emergency conditions.
Regional dementia care networks in Germany: changes in caregiver burden at one-year follow-up and associated factors

ABSTRACT Background: Recently, regional dementia care networks (DCNs) have been established in Germany to provide timely support for persons with dementia (PwDs) and their families. There is a lack of research in this setting. This study was conducted to describe the burden experienced by informal caregivers over the course of one year when utilizing a DCN and the factors affecting potential changes in caregiver burden during that time. Methods: The study was part of the DemNet-D project, a multi-center observational study of DCNs in Germany. Standardized questionnaires were administered during face-to-face interviews at baseline and at a one-year follow-up with PwDs and their informal caregivers who used a DCN. Based on qualitative data, four DCN governance types were identified and used in a multivariate analysis of burden categories. Results: A total of 389 PwD-informal caregiver dyads completed the follow-up assessment. At follow-up, the dyads reported significantly lower scores for burden in relation to practical care tasks, conflicts of need, and role conflicts. This change was associated with the PwD–caregiver relationship, the caregiver's gender and health status, and the PwD's socio-economic status. The governance structure of the DCNs was associated with change in one of the four burden categories. Conclusions: Our data provide the first indications that different governance structures of DCNs seem to be similarly well suited to support network users and might contribute to reducing caregiver burden. However, further studies set in DCNs examining factors that mediate changes in burden are needed to draw strong conclusions regarding the effectiveness of DCNs. Gender differences and the PwD–caregiver relationship should be considered by DCN stakeholders when developing support structures.
Nubbin isoform antagonism governs Drosophila intestinal immune homeostasis

Gut immunity is regulated by intricate and dynamic mechanisms to ensure homeostasis despite a constantly changing microbial environment. Several regulatory factors have been described to participate in feedback responses to prevent aberrant immune activity. Little is, however, known about how transcriptional programs are directly tuned to efficiently adapt host gut tissues to the current microbiome. Here we show that the POU/Oct gene nubbin (nub) encodes two transcription factor isoforms, Nub-PB and Nub-PD, which antagonistically regulate immune gene expression in Drosophila. Global transcriptional profiling of adult flies overexpressing Nub-PB in immunocompetent tissues revealed that this form is a strong transcriptional activator of a large set of immune genes. Further genetic analyses showed that Nub-PB is sufficient to drive expression both independently and in conjunction with nuclear factor kappa B (NF-κB), JNK and JAK/STAT pathways. Similar overexpression of Nub-PD did, conversely, repress expression of the same targets. Strikingly, isoform co-overexpression normalized immune gene transcription, suggesting antagonistic activities. RNAi-mediated knockdown of individual nub transcripts in enterocytes confirmed antagonistic regulation by the two isoforms and that both are necessary for normal immune gene transcription in the midgut. Furthermore, enterocyte-specific Nub-PB expression levels had a strong impact on gut bacterial load as well as host lifespan. Overexpression of Nub-PB enhanced bacterial clearance of ingested Erwinia carotovora carotovora 15. Nevertheless, flies quickly succumbed to the infection, suggesting a deleterious immune response. In line with this, prolonged overexpression promoted a proinflammatory signature in the gut with induction of JNK and JAK/STAT pathways, increased apoptosis and stem cell proliferation. These findings highlight a novel regulatory mechanism of host-microbe interactions mediated by antagonistic transcription factor isoforms.
MODELING THE EFFECTS OF DAMAGE AND MICROSTRUCTURAL EVOLUTION ON THE CREEP BEHAVIOR OF ENGINEERING ALLOYS

A quantitative representation of the creep behavior of materials is required to determine the operating lives of high temperature plant. Although the creep performance of such materials is normally governed by the development of microstructural features that can either be associated with the normal aging phenomena or by the development of damage in the material, most previous analyses of creep data have been empirical. It has been implicitly assumed that similar forms of creep curves can be adequately represented by a single generic equation. However, it is clear that different materials are subject to different combinations of structural change during their creep lives (e.g., cavitation/cracking, particle coarsening, phase changes, dislocation accumulation) all of which can influence the creep performance. An empirical representation can always be made to fit an available database, but effective extrapolation to longer lives and more complex loading conditions requires that the differing mechanisms be integrated in the creep equations. This paper will explore the implications of the evolution of microstructure and damage on the creep performance of a range of materials and will consider the potential of a microstructure-based state-variable (or damage-mechanics) approach for improved design life prediction of new plant and remaining life assessment of geriatric plant.
Optimal project feature weights in analogy-based cost estimation: improvement and limitations

Cost estimation is a vital task in most important software project decisions such as resource allocation and bidding. Analogy-based cost estimation is particularly transparent, as it relies on historical information from similar past projects, whereby similarities are determined by comparing the projects' key attributes and features. However, one crucial aspect of the analogy-based method is not yet fully accounted for: the different impact or weighting of a project's various features. Current approaches either try to find the dominant features or require experts to weight the features. Neither of these yields optimal estimation performance. Therefore, we propose to allocate separate weights to each project feature and to find the optimal weights by extensive search. We test this approach on several real-world data sets and measure the improvements with commonly used quality metrics. We find that this method 1) increases estimation accuracy and reliability, 2) reduces the model's volatility and, thus, is likely to increase its acceptance in practice, and 3) indicates upper limits for analogy-based estimation quality as measured by standard metrics.
Measurement of breakage energy of coarse granular aggregates

Particle breakage of coarse granular aggregates changes its structure directly, influencing its dilatancy and friction angle. In the course of shearing, normal stress and shear stress do work on volume strain and shear strain. This energy is transformed into particle elastic energy storage, particle friction energy consumption, work done by particle dilatancy and particle breakage energy. The accurate measurement on breakage energy of coarse granular aggregates in the course of shearing aims that it provides a method to analyze the particle breakage influence on constitutive relation in the perspective of energy, creating conditions for development of coarse granular aggregates constitutive relations considering particle breakage. The breakage energy of coarse granular aggregates in the course of shearing is calculated by analyzing the results of the coarse granular aggregates in triaxial compression test. The results indicate that the breakage energy during triaxial tests is mainly influenced by confining stress and friction coefficient.
Effect of Elastic Modulus of Adhesives on Stress Distribution in Weld-bonded Joints

The effect of the elastic modulus of adhesives on the stress distribution in aluminumalloy weld-bonded single lap joint under loading was investigated using the elastic-plastic finite element method(FEM). The results showed that the stress distribution in the overlap zone was more uniform as the elastic modulus of the adhesive increased along the horizontal plane and the peak stresses occurred adjacent to the adhesive layer decreased evidently,but the peak stresses in mid-bondline near the free end of the lap zone was increased.At the plane 0.05 mm away from the mid-bondline,the peak stresses at the point corresponding to the center of the spot nugget at the joint decreased greatly when the elastic modulus increased.