Miracle-dz/UniFAR-FTUs huggingface dataset:
Telecare Services for Elderly: Predictive Factors of Continued Use Intention

Background: Several countries have recently attempted to implement telecare information technology to provide health care to older adults. This study applied self-determination theory (autonomy, relatedness, and competence) and the theory of planned behavior (subjective norm, perceived behavioral control, and attitudes toward using tools) to investigate a theoretical model for explaining the predictive factors influencing the intention of elderly patients to continue using telecare services. Methods: Elderly patients in Taiwan (N = 160) who used telecare systems and fall-detection systems completed a questionnaire. Hierarchical multiple regression analysis was applied to test hypotheses. Results: The results revealed that the main effects related to identification supported the notion that autonomy, relatedness, subjective norm, and attitudes toward using tools positively affect elderly patients’ intention to continue using telecare services. But, perceived competence and perceived behavioral control cannot be used as a predictor of intention to adopt telecare services. Conclusion: For an aging society, to provide appropriate ways to enhance elderly patients’ willingness to use telecare services is important. Our findings indicate that elderly patients’ perceived relatedness and subjective norm are both crucial predictors in intention to adopt telecare services. And it means that social influence may play a critical role in elderly patients’ intention to adopt telecare services; therefore, researchers can investigate social influence mechanisms in depth and examine them more closely in future research.
Granular Cell Astrocytomas Show a High Frequency of Allelic Loss but are not a Genetically Defined Subset

Granular cell astrocytomas (GCA) are an uncommon morphologic variant of infiltrative glioma that contains a prominent population of atypical granular cells. As a rule, they are biologically aggressive compared to similar tumors without granular features. We sought to determine whether GCAs possess distinct genotypic alterations that might reflect their unique morphology or clinical behavior. Eleven GCAs occurring in 7 men and 4 women ranging in age from 46 to 75 years were investigated for genetic alterations of known significance in glial tumorigenesis, including LOH at 1p, 9p, 10q, 17p, and 19q, point mutations of TP53, deletions of p16(CDKN2A) and p14ARF, as well as EGFR amplifications. Tumors included had an infiltrative growth pattern and consisted of large, round cells packed with eosinophilic, PAS‐positive granules that varied in quantity, ranging from 30 to 100% of tumor cells. Three tumors were of WHO grade II, one was grade III, and 7 were grade IV lesions. Overall, the tumors showed higher frequencies of LOH at 1p, 9p, 10q, 17p, and 19q than typical infiltrating astrocytomas of similar grades. Losses on 9p and 10q occurred in nearly all cases, including low grade lesions. TP53 mutations were identified in 2 grade IV GCAs, while combined p14ARF and p16(CDKN2A) homozygous deletions were noted in only one grade IV lesion. None showed EGFR amplification. We found no genetic alterations specific for GCA. Instead, it appears that granular cell change occurs across genetic subsets. The high frequency of allelic loss, especially on 9p and 10q, may confer aggressive growth potential and be related to their rapid clinical progression.
Follicular variant of papillary thyroid carcinoma: a long-term follow-up.

HYPOTHESIS The clinical behavior of the follicular variant of papillary thyroid carcinoma (FVPTC) is similar to pure papillary thyroid carcinoma (PPTC) and completely different from follicular thyroid carcinoma (FTC). DESIGN Retrospective analysis of prospectively documented data. SETTING Referral center of a university hospital. PATIENTS Two hundred thirty-seven consecutive patients with follicular cell-derived thyroid carcinomas were operated on in our institution during a 15-year period, from January 1, 1980, to December 31, 1994. Of the 154 PTC patients, 37 (24%) had FVPTC. The mean follow-up was 128.2 months (10.7 years). MAIN OUTCOME MEASURES Demographic features, tumor characteristics, local and distant spread, persistence or recurrence of disease, and carcinoma-related mortality were compared between the groups with FVPTC, PPTC, and non-Hürthle cell FTC (NHFTC). RESULTS The frequency of multicentricity was significantly higher in the FVPTC group than in the PPTC group (P =.03) or in the NHFTC group (P =.01) (12 [32%] of 37 patients vs 17 [15%] of 117 patients vs 6 [10%] of 58 patients, respectively). The incidence of cervical lymph node metastases was lower in the FVPTC group than in the PPTC group (P =.30) and higher than in NHFTC group (P =.004) (12 [32%] of 37 patients vs 53 [45%] of 117 patients vs 6 [10%] of 58 patients, respectively). At diagnosis, no patient with FVPTC showed distant metastases, compared with 5 patients (4%) with PPTC (P =.34) and 19 (33%) with NHFTC (P<.001). There was no carcinoma-related death in the FVPTC group. The strikingly poorer prognosis for the NHFTC group was statistically significant (P<.001), whereas the difference in carcinoma-specific survival between the PPTC and the FVPTC groups did show a trend toward better survival in the FVPTC group. CONCLUSION The clinical behavior of the FVPTC group did not differ significantly from that of the PPTC group, whereas compared with the NHFTC group, the FVPTC group showed statistically significant differences for most of the analyzed variables.
Neural Machine Translation by Minimising the Bayes-risk with Respect to Syntactic Translation Lattices

We present a novel scheme to combine neural machine translation (NMT) with traditional statistical machine translation (SMT). Our approach borrows ideas from linearised lattice minimum Bayes-risk decoding for SMT. The NMT score is combined with the Bayes-risk of the translation according the SMT lattice. This makes our approach much more flexible than n-best list or lattice rescoring as the neural decoder is not restricted to the SMT search space. We show an efficient and simple way to integrate risk estimation into the NMT decoder which is suitable for word-level as well as subword-unit-level NMT. We test our method on English-German and Japanese-English and report significant gains over lattice rescoring on several data sets for both single and ensembled NMT. The MBR decoder produces entirely new hypotheses far beyond simply rescoring the SMT search space or fixing UNKs in the NMT output.
Expression and localization of members of the thrombospondin family during final follicle maturation and corpus luteum formation and function in the bovine ovary

The aim of this study was to characterize the expression patterns and localization of the thrombospondin family members (THBS1, THBS2) and their receptors (CD36 and CD47) in bovine ovaries. First, the antral follicles were classified into 5 groups based on the follicle size and estradiol-17beta (E2) concentration in the follicular fluid (< 0.5, 0.5–5, 5–40, 40–180 and >180 E2 ng/ml). Second, the corpus luteum (CL) was assigned to the following stages: days 1–2, 3–4, 5–7, 8–12, 13–16 and >18 of the estrous cycle and of pregnancy (month 1–2, 3–4, 6–7 and > 8). Third, the corpora lutea were collected by transvaginal ovariectomy before and 0.5, 2, 4, 12, 24, 48 and 64 h after inducing luteolysis by injecting a prostaglandin F2alpha analog. The mRNA expression of examined factors was measured by RT-qPCR, steroid hormone concentration by EIA, and localization by immunohistochemistry. The mRNA expression of THBS1, THBS2, CD36, and CD47 in the granulosa cells and theca interna was high in the small follicles and reduced in the preovulatory follicles. The mRNA expression of THBS1, THBS2, and CD47 in the CL during the estrous cycle was high, but decreased significantly during pregnancy. After induced luteolysis, thrombospondins increased significantly to reach the maximum level at 12 h for THBS1, 24 h for THBS2, and 48 h for CD36. The temporal expression and localization pattern of the thrombospondins and their specific receptors in the antral follicles and corpora lutea during the different physiological phases of the estrous cycle and induced luteolysis appear to be compatible with their inhibitory role in the control of ovarian angiogenesis.
Distinctive effects of CCR5, CCR2, and SDF1 genetic polymorphisms in AIDS progression.

The Genetics of Resistance to Infection by HIV-1 (GRIV) cohort represents 200 nonprogressor/slow-progressor (Slowprog) and 90 fast-progressor (Fastprog) HIV-1-infected patients. Using this unique assembly, we performed genetic studies on three recently discovered polymorphisms of CCR5, CCR2, and SDF1, which have been shown to slow the rate of disease progression. The increased prevalence of mutant alleles among Slowprogs from the GRIV cohort was significant for CCR5 (p < .0001) but not for CCR2 (p = .09) or SDF1 (p = . 12), emphasizing the predominant role of CCR5 as the major HIV-1 coreceptor. However, the prevalence of the CCR2 mutant allele (64I) was significantly increased among Slowprogs homozygous for wild-type CCR5 compared with Fastprogs (p = .04). The prevalence of double mutants SDF1-3'A/3'A genotypes was also increased among Slowprogs homozygous for wild-type CCR5 compared with Fastprogs (p = .05). The effects of the CCR2 and SDF1 mutations are overshadowed by the protective effects of the CCR5 deletion. Predictive biologic markers such as CD4 cell counts or viral load in the Slowprog population did not show significant differences between Slowprog groups with wild-type or mutant alleles for the three genes. Thus, our data suggest that the effects of these genes are exerted earlier in infection and no longer evident in the Slowprog of the GRIV cohort whose average duration of HIV infection is 12 years. We conclude that these genes, whose products serve as viral coreceptors or their ligands, may play a role early in infection and delay the onset of disease. However, among Slowprogs, whose duration of infection is >8 years, they are no longer influential for maintenance of their longterm nonprogression status. Other genetic determinants may be responsible for late protective effects.
The Representation of Abstract Task Rules in the Human Prefrontal Cortex

We have previously reported sustained activation in the ventral prefrontal cortex while participants prepared to perform 1 of 2 tasks as instructed. But there are studies that have reported activation reflecting task rules elsewhere in prefrontal cortex, and this is true in particular when it was left to the participants to decide which rule to obey. The aim of the present experiment was to use functional magnetic resonance imaging (fMRI) to find whether there was activation in common, irrespective of the way that the task rules were established. On each trial, we presented a word after a variable delay, and participants had to decide either whether the word was abstract or concrete or whether it had 2 syllables. The participants either decided before the delay which task they would perform or were instructed by written cues. Comparing the self-generated with the instructed trials, there was early task set activation during the delay in the middle frontal gyrus. On the other hand, a conjunction analysis revealed sustained activation in the ventral prefrontal and polar cortex for both conditions. We argue that the ventral prefrontal cortex is specialized for handling conditional rules regardless of how the task rules were established.
Validation of the Social Security Death Index (SSDI): An Important Readily-Available Outcomes Database for Researchers

Study Objective To determine the accuracy of the online Social Security Death Index (SSDI) for determining death outcomes. Methods We selected 30 patients who were determined to be dead and 90 patients thought to be alive after an ED visit as determined by a web-based searched of the SSDI. For those thought to be dead we requested death certificates. We then had a research coordinator blinded to the results of the SSDI search, complete direct follow-up by contacting the patients, family or primary care physicians to determine vital status. To determine the sensitivity and specificity of the SSDI for death at six months in this cohort, we used direct follow-up as the criterion reference and calculated 95% confidence intervals. Results Direct follow-up was completed for 90% (108 of 120) of the patients. For those patients 20 were determined to be dead and 88 alive. The dead were more likely to be male (57%) and older [(mean age 83.9 (95% CI 79.1 – 88.7) vs. 60.9 (95% CI 56.4 – 65.4) for those alive]. The sensitivity of the SSDI for those with completed direct follow-up was 100% (95% CI 91 –100%) with specificity of 100% (95% CI 98–100%). Of the 12 patients who were not able to be contacted through direct follow-up, the SSDI indicated that 10 were dead and two were alive. Conclusions SSDI is an accurate measure of death outcomes and appears to have the advantage of finding deaths among patients lost to follow-up.
Comparison of the effect of supraperiosteal versus subperiosteal dissection on the growing rabbit maxilla.

OBJECTIVE To achieve closure of wide unilateral cleft lip repair without tension of the cleft lip margins, a large undermining, especially of the anterolateral surface of the maxilla, is needed. Two types of dissection are feasible: supraperiosteal or subperiosteal. The aim of this study was to investigate whether there are differences in maxillary growth between healthy rabbits after supraperiosteal or subperiosteal dissection. METHODS Twenty-four male 7-week-old New Zealand white rabbits were divided randomly into three groups: eight control animals (untreated); eight animals undergoing supraperiosteal dissection of the left surface of the maxilla, and eight animals undergoing subperiosteal dissection of the left surface of the maxilla. All of the treated animals were operated on by the same surgeon at age of 7 weeks and sacrificed at 27 weeks together with control group animals. Seven cephalometric measures (representing aspects of maxillary length, width, and height), on the left side, were taken on the cleaned skull of the rabbits, and the results were analyzed statistically. RESULTS No significant differences in maxillary growth were noted across the three study groups. CONCLUSIONS The supraperiosteal or subperiosteal undermining of the anterolateral surface of the maxilla does not seem to interfere with the growth of the normal maxilla in the rabbit.
Signed difference analysis : A brief introduction By

The following is a introduction to a method, called signed difference analysis (or SDA), that I have been developing, off and on, over the last seven years. SDA is a general technique for evaluating psychological models using only the “non-metric” or ordinal properties of dependent variables. Although still a work in progress, the following is an outline of its main elements which, hopefully, will communicate the basic idea of SDA and give some indication of how and where it can be applied. The article is divided into four parts. In the first part, I discuss the central problem of psychological measurement that SDA attempts to address. In the second part, I present a concrete example of a psychological model and, in the third part, show how SDA can be used to derive predictions that use only ordinal information. In the final part, I discuss the possible application of SDA to cognitive neuropsychology.
Inhibition of dipeptidyl peptidase-4: The mechanisms of action and clinical use of vildagliptin for the management of type 2 diabetes

Postprandial hyperglycemia in type 2 diabetes is characterized by impaired insulin secretion and action, decreased glucose effectiveness and defective suppression of glucagon secretion. Newly available therapies for type 2 diabetes target the pathway of the incretin hormone glucagon-like peptide-1 (GLP-1). Oral inhibitors of dipeptidyl peptidase-4 (DPP-4) raise the level of endogenous GLP-1 by inhibiting its clearance thereby lowering fasting and postprandial glucose concentrations. Unlike compounds which act as agonists of the GLP-1 receptor, DPP-4 inhibitors are not associated with significant effects on gastrointestinal motility, which led to a controversy around the mechanisms responsible for their glucose-lowering effects. Here we review the evidence in regards to the mechanisms whereby DPP-4 inhibitors lower glucose concentrations. Their effects are most likely mediated by an increase in endogenous GLP-1, although additional mechanisms may be involved. The pharmacology, efficacy and safety of vildagliptin, a novel DPP-4 inhibitor, are also discussed.
Does basal luteinizing hormone help predict the fate of in vitro fertilization?

OBJECTIVE Evaluate the role of baseline serum luteinizing hormone (LH) in predicting the success of in-vitro fertilization (IVF) in terms of clinical pregnancy and live birth rate. METHODS Women who underwent IVF and/or intracytoplasmic sperm injection (ICSI), following either the agonist or the antagonist protocol, were retrospectively evaluated over a period of two years at the All India Institute of Medical Sciences, New Delhi. We investigated the correlation of serum LH levels in the follicular phase with pregnancy outcomes. A P-value lower than 0.05 was considered as statistically significant. RESULTS The individuals (351) were divided into four groups based on LH and FSH baseline values, and the levels were correlated with clinical pregnancy and live births. The highest clinical pregnancy rate (25%) was achieved in women with low LH (< 2IU/l); whereas the miscarriage rate was almost similar in all the groups. The pregnancy rate was the lowest (16%) in women with high LH levels (> 8IU/L). Pregnancy rates were intermediate (20%) if LH was intermediate (2-8IU/L). However, none of the results had statistical significance. CONCLUSIONS Early follicular serum LH levels before an IVF/ICSI treatment cycle did not have any clear relationship with clinical pregnancy or live birth rates.
Managing the human component of fire regimes: lessons from Africa

Human impacts on fire regimes accumulated slowly with the evolution of modern humans able to ignite fires and manipulate landscapes. Today, myriad voices aim to influence fire in grassy ecosystems to different ends, and this is complicated by a colonial past focused on suppressing fire and preventing human ignitions. Here, I review available evidence on the impacts of people on various fire characteristics such as the number and size of fires, fire intensity, fire frequency and seasonality of fire in African grassy ecosystems, with the intention of focusing the debate and identifying areas of uncertainty. Humans alter seasonal patterns of fire in grassy systems but tend to decrease total fire emissions: livestock have replaced fire as the dominant consumer in many parts of Africa, and fragmented landscapes reduce area burned. Humans alter the season and time of day when fires occur, with important implications for fire intensity, tree–grass dynamics and greenhouse gas (GHG) emissions. Late season fires are more common when fire is banned or illegal: these later fires are far more intense but emit fewer GHGs. The types of fires which preserve human livelihoods and biodiversity are not always aligned with the goal of reducing GHG concentrations. Current fire management challenges therefore involve balancing the needs of a large rural population against national and global perspectives on the desirability of different types of fire, but this cannot happen unless the interests of all parties are equally represented. In the future, Africa is expected to urbanize and land use to intensify, which will imply different trajectories for the continent's fire regimes. This article is part of the themed issue ‘The interaction of fire and mankind.
Strongylocentrotus drobachiensis oocytes maintain a microtubule organizing center throughout oogenesis: Implications for the establishment of egg polarity in sea urchins

Although it has been known for over a century that sea urchin eggs are polarized cells, very little is known about the mechanism responsible for establishing and maintaining polarity. Our previous studies of microtubule organization during sea urchin oogenesis described a cortical microtubule‐organizing center (MTOC) present during germinal vesicle (GV) migration in large oocytes. This MTOC was localized within the future animal pole of the mature egg. In this study we have used electron microscopy and immunocytochemistry to characterize the structure of this MTOC and have established that this organelle appears prior to GV migration. We show that the cortical MTOC contains all the components of a centrosome, including a pair of centrioles. Although a centrosome proper was not found in small oocytes, the centriole pair in these cells was always found in association with a striated rootlet, a structural remnant of the flagellar apparatus present in precursor germinal cells (PGCs). The centrioles/striated rootlet complex was asymmetrically localized to the side of the oocyte closest to the gonadal wall. These data are consistent with the previously proposed hypothesis that in echinoderms the polarity of the PGCs in the germinal epithelium influences the final polarity of the mature egg. Mol. Reprod. Dev. 74: 76–87, 2007. © 2006 Wiley‐Liss, Inc.
Minority Language Twitter: Part-of-Speech Tagging and Analysis of Irish Tweets

Noisy user-generated text poses problems for natural language processing. In this paper, we show that this statement also holds true for the Irish language. Irish is regarded as a low-resourced language, with limited annotated corpora available to NLP researchers and linguists to fully analyse the linguistic patterns in language use in social media. We contribute to recent advances in this area of research by reporting on the development of part-ofspeech annotation scheme and annotated corpus for Irish language tweets. We also report on state-of-the-art tagging results of training and testing three existing POStaggers on our new dataset.