Miracle-dz/UniFAR-FTUs huggingface dataset:
Standardized Bacopa monnieri extract ameliorates acute paraquat-induced oxidative stress, and neurotoxicity in prepubertal mice brain

Objectives: Bacopa monnieri (BM), an ayurvedic medicinal plant, has attracted considerable interest owing to its diverse neuropharmacological properties. Epidemiological studies have shown significant correlation between paraquat (PQ) exposure and increased risk for Parkinson's disease in humans. In this study, we examined the propensity of standardized extract of BM to attenuate acute PQ-induced oxidative stress, mitochondrial dysfunctions, and neurotoxicity in the different brain regions of prepubertal mice. Methods: To test this hypothesis, prepubertal mice provided orally with standardized BM extract (200 mg/kg body weight/day for 4 weeks) were challenged with an acute dose (15 mg/kg body weight, intraperitoneally) of PQ after 3 hours of last dose of extract. Mice were sacrificed after 48 hours of PQ injection, and different brain regions were isolated and subjected to biochemical determinations/quantification of central monoamine (dopamine, DA) levels (by high-performance liquid chromatography). Results: Oral supplementation of BM for 4 weeks resulted in significant reduction in the basal levels of oxidative markers such as reactive oxygen species (ROS), malondialdehyde (MDA), and hydroperoxides (HP) in various brain regions. PQ at the administered dose elicited marked oxidative stress within 48 hours in various brain regions of mice. However, BM prophylaxis significantly improved oxidative homeostasis by restoring PQ-induced ROS, MDA, and HP levels and also by attenuating mitochondrial dysfunction. Interestingly, BM supplementation restored the activities of cholinergic enzymes along with the restoration of striatal DA levels among the PQ-treated mice. Discussion: Based on these findings, we infer that BM prophylaxis renders the brain resistant to PQ-mediated oxidative perturbations and thus may be better exploited as a preventive approach to protect against oxidative-mediated neuronal dysfunctions.
Semantic Technologies for the IoT - An Inter-IoT Perspective

The Inter-IoT project is aiming at the design and implementation of, and experimentation with, an open cross-layer framework and associated methodology, to provide voluntary interoperability among heterogeneous Internet of Things (IoT) platforms. The project is initially driven by uses cases from two domains: (e/m) Health and transportation and logistics in a port environment. While the Inter-IoT will provide interoperability across the software stack, here, we focus our attention on the semantic interoperability. In this context, we present a concise overview of existing IoT-related semantic approaches, which might either be directly applicable to, or serve as a source of inspiration for, the Inter-IoT applications.
A pilot clinical study of hair grafting in chronic leg ulcers

Epidermal sheets spread centrifugally postinjury from the hair follicle infundibulum to reepithelialize the wound bed. Healing progresses faster in skin areas rich in terminal hair follicles. These observations are consistent with the role of the hair follicle as a major reservoir for progenitor cells. To evaluate the feasibility and potential healing capacity of autologous scalp follicular grafts transplanted into the wound bed of chronic leg ulcers, 10 patients with ulcers of an average 36.8 cm2 size and a 10.5‐year duration were included in this pilot study. Within each ulcer we randomly assigned a 2 × 2 cm “experimental” square to receive 20 hair grafts and a nongrafted “control” square of equal size. The procedure seemed to be safe, although major unrelated complications occurred in two patients. At the 18‐week end point, we observed a 27.1% ulcer area reduction in the experimental square as compared with 6.5% in the control square (p = 0.046) with a maximum 33.5% vs. 9.7% reduction at week 4 (p = 0.007). Histological analyses showed enhanced epithelialization, neovascularization, and dermal reorganization. We conclude that terminal hair follicle grafting into wound beds is feasible in an outpatient setting and represents a promising therapeutic alternative for nonhealing chronic leg ulcers.
Signals for color and achromatic contrast in the goldfish inner retina

Abstract A moving stimulus paradigm was designed to investigate color contrast encoding in the retina. Recently, this paradigm yielded suggestive evidence for color contrast encoding in zebrafish but the significance and generality remain uncertain since the properties of color coding in the zebrafish inner retina are largely unknown. Here, the question of color contrast is pursued in the goldfish retina where there is much accumulated evidence for retinal mechanisms of color vision and opponent color-coding, in particular. Recordings of a sensitive local field potential of the inner retina, the proximal negative response, were made in the intact, superfused retina in the light-adapted state. Responses to color contrast and achromatic contrast were analyzed by comparing responses to a green moving bar on green versus red backgrounds. The quantitative form of the irradiance/response curves was distinctly different under a range of conditions in 32 retinas, thereby providing robust evidence for red–green color contrast. The color contrast is based on successive contrast, occurs in the absence of overt color opponency, and clearly differs from previous findings in the goldfish retina for simultaneous color contrast mediated by color-opponent neurons. The form of the irradiance/response curves suggests that successive color contrast is particularly important when achromatic contrast is low, as often occurs in natural environments. The present results provide a parallel with the well-known principle of human color vision, first proposed by Kirschmann as the third law of color contrast, and may also have implications for the evolution of vertebrate color vision.
The role of magnesium sulfate in tracheal intubation without muscle relaxation in patients undergoing ophthalmic surgery

Background: Muscle relaxant agents usually use to facilitate tracheal intubation; however, sometimes limitations exist. Magnesium (Mg) sulfate is a candidate for muscle relaxant substitute. This study was designed to determine the effect of Mg sulfate accompanied with propofol and fentanyl in patients undergoing ophthalmic surgery. Materials and Methods: In a double-blind randomized protocol and before tracheal intubation, Mg sulfate 40, 45, or 50 mg/kg in 100 ml of saline (Groups 1–3, respectively) or saline alone (Group 4) were administrated intravenously in 100 patients (n = 25 in each group) with the American Society of Anesthesiologist (ASA) physical Status I, II, or III. The patients' intubation condition in all subjects were determined and described. Results: The patients' demographic data including age, ASA, systolic and diastolic blood pressures, intraocular pressure, and body mass index were not significantly different between the groups. A better mask ventilation feasibility in Mg sulfate 45 group (Group 2) was observed when compared with Mg sulfate 50 (Group 3) (P = 0.022) and saline group (Group 4) (P = 0.021). In addition, the vocal cord movement and muscle relaxant requirement in saline group were significantly different from others groups (P < 0.05). The laryngoscopic time in saline group was greater than other groups significantly (P < 0.0001). Conclusion: Intravenous administration of Mg sulfate accompanied with propofol and fentanyl facilitates the tracheal intubation without neuromuscular blocking agents. To avoid Mg level increasing in plasma; however, the low dose of Mg sulfate is suggested.
A Comparative Study of Refusals: Gender Distinction and Social Status in Focus

This study investigated the differences between Iranian EFL learners’ use of English and Persian refusals. It also examined the influence of social status and gender on the provided responses. The participants of this study were 60 graduate Iranian students mastering in English. They were divided equally into males and females. The study was done in two phases with an interval time of two months. The same participants participated in both phases. Once they sat for the English version of the test and once for the Persian one. The DCT's provided data were analyzed to show the average frequencies of direct and indirect strategy use, the types of employed strategies, and the effects of participants' social status and gender on the responses. The results showed that participants used more indirect strategies in the Persian in comparison to the English. No significant difference was observed between males and females refusal strategies. As for social status, the finding showed that the Persian group used more indirect strategy when talking to someone of a higher class.
In vivo study of indomethacin in bronchiectasis: effect on neutrophil function and lung secretion.

Bronchiectasis is associated with sputum containing high levels of the proteolytic enzyme elastase, which is thought to be involved in the pathogenesis of the disease. Agents which inhibit neutrophil function and interfere with neutrophil elastase release may have a beneficial effect on the development and progression of such diseases. We have studied the effects of the nonsteroidal anti-inflammatory agent indomethacin on neutrophil function in nine patients with clinically stable bronchiectasis. All patients remained clinically stable during the study. We observed a significant reduction in peripheral neutrophil chemotaxis to 10 nmol.L-1 N-formyl-methionyl-leucyl-phenylalanine (FMLP) from a mean of 19.86 (SEM 1.35) to 8.46 (0.68) cells.field-1 after 4 weeks of therapy. There was also a significant reduction in fibronectin degradation both by resting and FMLP-stimulated neutrophils, from a mean of 1.90 (0.19) micrograms x 3 x 10(5) cells at the start of therapy to 0.87 (0.08) micrograms after 4 weeks, and from 3.17 (0.35) micrograms to 1.48 (0.05) micrograms, respectively. There was no effect on spontaneous or stimulated superoxide anion generation by neutrophils. Despite the marked changes in peripheral neutrophil function, no adverse effect was observed on viable bacterial load in the bronchial secretions. In addition, there was no difference in sputum albumin, elastase or myeloperoxidase levels, and only minor changes in the chemotactic activity of the sputum. These results suggest that nonsteroidal anti-inflammatory agents have a major effect on peripheral neutrophil function but do not appear to have an adverse effect on bacterial colonization of the airways.
Evidence for an Interference of Selective Face Ventilation on Hyperprolactinemia Induced by Hyperthermic Treadmill Running

Selective face ventilation, known to interfere with bloodstreamed temperature signals, should alter exercise-induced prolactinemic (PRL) responses if, as recently suggested, the latter responses are associated with body temperature increases generated by working muscles. To test this hypothesis, 15 trained adult male and female volunteers were submitted to 45-min hyperthermic treadmill runs with and without selective face ventilation. Tympanic (Tt) and rectal (Tr) temperatures were measured in these experiments, and serum immunoreactive PRL was assayed on venous blood sampled immediately before and immediately after the exercise. Hyperthermic running induced significant Tr elevations whether selective face ventilation was present or not. In the absence of face ventilation, serum PRL rose markedly in 11 of the 15 hyperthermic runners, the lack of response in 4 runners confirming that exercise per se is not necessarily hyperprolactinotrophic. When the 11 responders (11/15) ran with face ventilation, serum PRL response was abolished in 6 of them, indicating a significant interference from face ventilation on temperature signals streamed through carotid blood; serum PRL-maintained responses in 5 of these 11 ventilated runners suggest the absence of a learning effect. It is concluded that the blood-streamed temperature signals arising from working muscles represent an important but not a unique determinant of blood PRL response during aerobic running. The contribution of TRH and plasma volume changes to blood PRL variations during hyperthermic running appeared nonsignificant.
Intracranial pressure and cerebral perfusion pressure responses to head elevation changes in pediatric traumatic brain injury*

Objectives: To determine the effect of and dynamic interaction between head elevation on intracranial pressure and cerebral perfusion pressure in severe pediatric traumatic head injury. Design: Prospective, randomized, interventional cohort study. Setting: Two tertiary pediatric critical care referral units. Patients: Ten children admitted with severe traumatic brain injury defined as Glasgow Coma Score ⩽8 necessitating intracranial pressure monitoring (10 yrs ± 5 SD; range 2–16 yrs). Interventions: Head elevation was randomly increased or decreased between 0 and 40 degrees from baseline level (30 degrees) in increments or decrements of 10 degrees. Measurements and Main Results: Intracranial pressure and arterial blood pressure were continuously recorded in combination with time-stamped clinical notations. Data were available for analysis in eight subjects (seven males and one female; mean age, 10 yrs ± SD 5; range, 2–16 yrs) during 18 protocol sessions. This resulted in a total of 66 head-of-the-bed challenges. To compare results for a given change in head-of-the-bed elevation across age, we transformed head-of-the-bed angle to change in height (cm) at the level of Monro's foramen. An increase in head elevation of 10 cm resulted in an average change in intracranial pressure of −3.9 mm Hg (SD ±3.2 mm Hg; p < .001), whereas cerebral perfusion pressure remained unchanged (0.1 ± 5.6 mm Hg; p = .957). Individual subjects showed marked variability in intracranial pressure change (range, −8.4 to +1.9 mm Hg/10 cm). The overall regression analysis for intracranial pressure response was change in intracranial pressure = −0.39/cm &Dgr;h, r2 = 0.42, and p < . 001, where &Dgr;h is the change in vertical height at the level of foramen of Monro attributable to a change in the head of the bed. Conclusions: In severe pediatric traumatic brain injury, the relationship between change in head of the bed and change in intracranial pressure was negative and linear. The lowest intracranial pressure was usually, but not always, achieved at highest head-of-the-bed angles. The effect size of a head-of-the-bed angle change depended, in part, on the subject's height. In contrast, cerebral perfusion pressure was mostly unaffected by head-of-the-bed changes.
Truthful assignment without money

We study the design of truthful mechanisms that do not use payments for the generalized assignment problem (GAP) and its variants. An instance of the GAP consists of a bipartite graph with jobs on one side and machines on the other. Machines have capacities and edges have values and sizes; the goal is to construct a welfare maximizing feasible assignment. In our model of private valuations, motivated by impossibility results, the value and sizes on all job-machine pairs are public information; however, whether an edge exists or not in the bipartite graph is a job's private information. That is, the selfish agents in our model are the jobs, and their private information is their edge set. We want to design mechanisms that are truthful without money (henceforth strategyproof), and produce assignments whose welfare is a good approximation to the optimal omniscient welfare. We study several variants of the GAP starting with matching. For the unweighted version, we give an optimal strategyproof mechanism. For maximum weight bipartite matching, we show that no strategyproof mechanism, deterministic or randomized, can be optimal, and present a 2-approximate strategyproof mechanism along with a matching lowerbound. Next we study knapsack-like problems, which, unlike matching, are NP-hard. For these problems, we develop a general LP-based technique that extends the ideas of Lavi and Swamy [14] to reduce designing a truthful approximate mechanism without money to designing such a mechanism for the fractional version of the problem. We design strategyproof approximate mechanisms for the fractional relaxations of multiple knapsack, size-invariant GAP, and value-invariant GAP, and use this technique to obtain, respectively, 2, 4 and 4-approximate strategyproof mechanisms for these problems. We then design an O(log n)-approximate strategyproof mechanism for the GAP by reducing, with logarithmic loss in the approximation, to our solution for the value-invariant GAP. Our technique may be of independent interest for designing truthful mechanisms without money for other LP-based problems.
Coalition formation during technology adoption

The Technology Acceptance Model (TAM) is a prominent framework that addresses the challenge of organisations to understand and promote the factors that lead to acceptance of new technologies. Nevertheless, our understanding of one of the model's key variables – social influence – remains limited. Drawing upon earlier studies that address the role of referent individuals to technology acceptance, this paper introduces the notion of ‘coalition’ as a social group that can affect the opinion of other members within an organisation. Our empirical study centres on an organisation that has recently decided to introduce Big Data into its formal operations. Through a unique empirical approach that analyses sentiments expressed by individuals about this technology on the organisation's online forum, we demonstrate the emergence of a central referent, and in turn the dynamics of a coalition that builds around this referent as the attitudes of individuals converge upon the Big Data issue. Our paper contributes to existing TAM frameworks by elaborating the social influence variable and providing a dynamic lens to the technology acceptance process. We concurrently offer a methodological tool for organisations to understand social dynamics that form about a newly introduced technology and accelerate its acceptance by employees.
Comparison of Body Composition Assessment Methods in Pediatric Intestinal Failure

Objectives: The aim of the study was to examine the agreement of multifrequency bioelectric impedance analysis (BIA) and anthropometry with reference methods for body composition assessment in children with intestinal failure (IF). Methods: We conducted a prospective pilot study in children 14 years or younger with IF resulting from either short bowel syndrome or motility disorders. Bland-Altman analysis was used to examine the agreement between BIA and deuterium dilution in measuring total body water (TBW) and lean body mass (LBM), and between BIA and dual-energy x-ray absorptiometry (DXA) techniques in measuring LBM and fat mass (FM). FM and percent body fat (%BF) measurements by BIA and anthropometry were also compared in relation to those measured by deuterium dilution. Results: Fifteen children with IF, median (interquartile range) age 7.2 (5.0, 10.0) years, and 10 (67%) boys, were studied. BIA and deuterium dilution were in good agreement with a mean bias (limits of agreement) of 0.9 (−3.2 to 5.0) for TBW (L) and 0.1 (−5.4 to 5.6) for LBM (kg) measurements. The mean bias (limits) for FM (kg) and %BF measurements were 0.4 (−3.8 to 4.6) kg and 1.7 (−16.9 to 20.3)%, respectively. The limits of agreement were within 1 standard deviation of the mean bias in 12 of 14 (86%) subjects for TBW and LBM, and in 11 of 14 (79%) for FM and %BF measurements. Mean bias (limits) for LBM (kg) and FM (kg) between BIA and DXA were 1.6 (−3.0 to 6.3) kg and −0.1 (−3.2 to 3.1) kg, respectively. Mean bias (limits) for FM (kg) and %BF between anthropometry and deuterium dilution were 0.2 (−4.2 to 4.6) and −0.2 (−19.5 to 19.1), respectively. The limits of agreement were within 1 standard deviation of the mean bias in 10 of 14 (71%) subjects. Conclusions: In children with IF, TBW and LBM measurements by multifrequency BIA method were in agreement with isotope dilution and DXA methods, with small mean bias and clinically acceptable limits of agreement. In comparison with deuterium dilution, BIA was comparable to anthropometry for FM and %BF assessments with small mean bias, but the limits of agreement were large. BIA is a reliable method for TBW and LBM assessments in population studies; however, its reliability in individual patients, especially for FM assessments, cannot be guaranteed.
Effects of positive interventions and orientations to happiness on subjective well-being

This study examined the effects of positive interventions and orientations to happiness on well-being. Participants were 218 self-selected adults randomly assigned to one of four positive interventions (pleasure, engagement, meaning or a combination), or daily events or no intervention control groups. Participants completed the Mental Health Continuum-Short Form and Orientations to Happiness Questionnaire. Analysis of variance results supported the hypothesis that well-being would significantly increase for participants in all intervention groups with those in the meaning, engagement, pleasure and combination groups showing larger increases than those in the control groups. Contrary to expectations, the control group also showed an increase in well-being. The prediction that participants’ dominant orientation to happiness would influence the success of the positive interventions in increasing well-being was supported at post-intervention but not at follow-up. Findings support the effectiveness of positive interventions in increasing well-being and underscore the importance of including individual difference factors such as Orientations to Happiness.