Miracle-dz/UniFAR-FTUs huggingface dataset:
The bleeding risk and natural history of idiopathic thrombocytopenic purpura in patients with persistent low platelet counts.

BACKGROUND No firm data are available on the natural history of idiopathic thrombocytopenic purpura (ITP) or on mortality rates or frequency of major bleeding episodes associated with this condition. The disease is thought to have a relatively benign course, despite the frequent occurrence of very low platelet counts. This prevailing conception often guides therapeutic decisions. OBJECTIVE To estimate the bleeding risk of ITP involving persistent low platelet counts (<30 x 10(9)/L) and its impact on prognosis. DESIGN Age-adjusted bleeding risk was derived from a pooled analysis of ITP clinical series based on a systematic literature search. The risk estimate was incorporated into a Markov model to determine its impact on prognosis. RESULTS Seventeen case series complied with inclusion criteria, including 1,817 patients with ITP. There were 49 cases of fatal hemorrhage over an estimated 1,258 to 3,023 patient-years at risk. The rate of fatal hemorrhage before age adjustment was estimated at between 0.0162 and 0.0389 cases per patient-year. Age-adjusted rates were 0.004, 0.012, and 0.130 cases per patient-year for age groups younger than 40, 40 to 60, and older than 60 years, respectively. Predicted 5-year mortality rates ranged from 2.2% for patients younger than 40 years to 47.8% for those older than 60 years. A 30-year-old woman remaining thrombocytopenic due to ITP was predicted to lose 20.4 years (14.9 quality-adjusted life years) of her potential life expectancy. At age 70, predicted loss was 9.4 years (5.0 quality-adjusted life years). CONCLUSIONS Idiopathic thrombocytopenic purpura with persistent low platelet counts carries a grave prognosis. Therefore, an active therapeutic approach in the clinical management of affected patients should be considered. In view of the significant potential implications of the model results, we call for initiating a well-designed prospective inception cohort study of patients with ITP.
SPEECH ACT OF ILTIFAT AND ITS INDONESIAN TRANSLATION PROBLEMS

Abstract: Iltifat ( shifting ) speech act is distinctive and considered unique style of Arabic. It has potential errors when it is translated into Indonesian. Therefore, translation of iltifat speech act into another language can be an important issue. The objective of the study is to know translation procedures/techniques and ideology required in dealing with iltifat speech act. This research is directed at translation as a cognitive product of a translator. The data used in the present study were the corpus of Koranic verses that contain iltifat speech act along with their translation. Data analysis typically used descriptive-evaluative method with content analysis model. The data source of this research consisted of the Koran and its translation. The purposive sampling technique was employed, with the sample of the iltifat speech act contained in the Koran. The results showed that more than 60% of iltifat speech act were translated by using literal procedure. The significant number of literal translation of the verses asserts that the Ministry of Religious Affairs tended to use literal method of translation. In other words, the Koran translation made by the Ministry of Religious Affairs tended to be oriented to the source language in dealing with iltifat speech act. The number of the literal procedure used shows a tendency of foreignization ideology. Transitional pronouns contained in the iltifat speech act can be clearly translated when thick translations were used in the form of description in parentheses. In this case, explanation can be a choice in translating iltifat speech act.
Association of different primers and resin cements for adhesive bonding to zirconia ceramics.

PURPOSE To evaluate the shear bond strength (SBS) to zirconia ceramics using different associations of primers and resin cements. MATERIALS AND METHODS Two blocks of LAVA zirconia (3Y-TZP) were randomly submitted to an application of three different commercially available primers: Alloy Primer (AP), Z-Prime Plus (ZP), and Signum Zirconia Bond (SZB). Nonprimed specimens were considered controls. After treatment, the 80 specimens (5 mm × 5 mm × 2 mm) were randomly cemented with one of the resin cements: Panavia F, Multilink, seT, and NX3. For cementation, cylinders of resin cement were built on the ceramic surfaces using the SDI SBS apparatus. The specimens were submitted to the SBS test. Fractured surfaces were observed under stereomicroscopy to determine the failure mode, and mean bond strength values were analyzed using the Kruskal-Wallis and Mann-Whitney tests (α = 0.05). RESULTS Signum Zirconia Bond had the highest SBS compared to all other primers and the control group, regardless of the resin cement used. The highest values were obtained when associating Panavia F with Signum Zirconia Bond. Alloy Primer increased bonding values when associated with seT cement only. When no primer was used, no statistical difference was observed among resin cements. All specimens fractured due to adhesive failure. CONCLUSION Signum Zirconia Bond is capable of increasing bonding values of resin cements to zirconia ceramics. Its association with Panavia F shows enhanced results when considering short-term adhesion to zirconia.
Whole Body Vibration Does Not Potentiate the Stretch Reflex

Whole body vibration (WBV) is theorized to enhance neural potentiation of the stretch reflex. The purpose of this study was to determine if WBV affects the quadriceps reflex from a patellar tendon tap. Subjects were 22 volunteers (age 23 +/- 2 yrs, ht 172.8 +/- 10.8 cm, body mass 68.6 +/- 12.3 kg). The stretch reflex was elicited from the dominant leg pre, post, and 30-min post WBV treatment. A matched control group repeated the procedure without WBV. WBV treatment consisted of 5, 1-min bouts at 26 Hz with a 1-min rest period between bouts while maintaining a standardized squatting position. Two-way ANOVAs were used to detect differences between groups over time for vastus medialis (VM) and vastus lateralis (VL) latency, EMG amplitude, electromechanical delay (EMD), and force output. No group x time interactions were detected for latency (VM; F ((2,40)) = 1.20, p = . 313: VL; F ((2,40)) = 0.617, p = . 544), EMG mean amplitude (VM; F ((2,40)) = 0.169, p = . 845: VL; F ((2,40)) = 0.944, p = . 398), EMD (VM; F ((2,40)) = 0.715, p = . 495: VL; F ((2,40)) = 1.24, p = . 301), or quadriceps force (F ((2,40)) = 1.11, p = . 341) A single session WBV treatment does not affect the quadriceps stretch reflex in terms of timing or amplitude.
Offshoring, Transition, and Training: Evidence from Danish Matched Worker-Firm Data

We combine matched Danish worker-firm-trade data with detailed individual-worker training data. We find: 1) workers displaced from offshoring firms take up more vocational-training and have a harder time getting re-attached to the labor-force than other displaced workers, and they also exhibit higher vocational-training take-up rates 2 years before layoffs; 2) the staying workers with offshoring firms take up more vocational-training than those with non-offshoring firms; and 3) the post-secondary-training take-up rates for displaced workers are no different than for the general population.
Academic logic and corporate entrepreneurial intentions: A study of the interaction between cognitive and institutional factors in new firms

This article studies the extent to which corporate entrepreneurial intentions are enacted differently by academic and non-academic entrepreneurs. Using constructs from cognitive research and exploiting the theory of institutional logics, we observe that academic entrepreneurs, notwithstanding their engagement in entrepreneurship, still implement their corporate entrepreneurial intentions acting in accordance with the academic institutional environment to which they belong. Using a matched-pairs research design, our results show that academic entrepreneurs (compared to non-academic ones) leverage their awareness of technical competencies significantly more and their entrepreneurial self-efficacy and awareness of managerial skills considerably less. We discuss the theoretical and managerial implications related to how cognitive and institutional factors interact to foster entrepreneurial value in newly established firms.
An analysis of failed takeover attempts and merger cancellations

Purpose - This study seeks to analyze the differences between merger cancellations and three types of takeover failures: failures that are associated with targeted share repurchases (greenmail), failures in which the sole bidder simply withdraws the offer, and failures that are accompanied by a general share repurchase (buyback). Design/methodology/approach - The paper uses event study methods and regression analysis. Findings - The paper observes negative target stock price reactions around all types of takeover failures and merger cancellations. However, the cumulative effect of takeover attempts is positive, suggesting that even unsuccessful tender offers generate permanent gains to target firm shareholders, while the cumulative effect of canceled mergers is negative. Furthermore, the market reaction to greenmail-induced takeover failure announcements is no worse than that of voluntary withdrawals, suggesting that greenmail may play an efficient role in mitigating the effects of takeover bid withdrawals. Finally, while bidder wealth is destroyed in takeover failures, the effect of merger cancellations on bidders is considerably more devastating. Originality/value - The paper provides evidence of negative stock price reactions to all forms of merger failure. The paper also shows that the cumulative effect of all types of takeover failures is still positive: suggesting that being put into play is still beneficial overall but that canceled mergers destroy value for both targets and bidders. The paper shows that the market reaction to greenmail-induced failure announcements is no worse than other forms of failure. Finally, while there is an immediate downturn in target prices around a failure, the negative outcome is more severe for the bidders. Thus, the market sees that there was something useful about the anticipated change in corporate control, which was lost when it failed to be completed.
With Friends Like These, Who Needs Enemies? The Structure of the Investment Industry and its Reluctance to Exercise Governance Oversight

A continuing obstacle to the success of most corporate governance initiatives is the unwillingness of the majority of institutional portfolio managers to co-operate with governance activists even to the extent of merely voting in cases where clear benefits would flow to all shareholders from a positive result. Portfolio managers have given many excuses for their lack of participation in such efforts, but upon examination, most turn out to be facile rationalisations. Institutional investors' negative attitudes towards governance may be attributed to scepticism on the part of some individuals, but there also seem to be structural factors at work. Some are integral to corporate governance itself: the difficulty of quantifying governance information, and the longer time horizon necessary for the realisation of most governance initiatives. Others are, however, a function of the structure of the investment industry: the different backgrounds and aptitudes of most corporate governance specialists from most investment managers, reliance upon third-party consultants, a different orientation towards investment, short-termism, differing career paths and perceptions, fear of bureaucratic intervention and competition for performance compensation. It is proposed that some internal readjustment of investment management companies, coupled with a clearer commitment by senior executives at those companies to exploit governance initiatives, would be beneficial both to the cause of better corporate governance and to portfolio returns. Copyright Blackwell Publishing Ltd 2005.
The Value Relevance of Accounting Income Reported By DAX-30 German Companies

International Financial Reporting Standards (IFRS) are required for consolidated financial statements of all European Union (EU) publicly traded companies starting from the December 2005 fiscal year end [Regulation (EC)]; and endorsed by the International Organization of Securities Commission (IOSCO) for its member countries beginning in 2000. We examine the challenges and benefits, including value relevance, of the adoption of IFRS by DAX-30 companies, the German premium stock market. Based on a survey sent to DAX-30 company executives, we find most companies agreeing that implementing IFRS should improve the comparability of financial statements. The complex nature, high cost of adopting and lack of guidance for implementing IFRS, as well as increased volatility of earnings after adopting IFRS, are listed among the most important challenges of conversion to IFRS. We use regression to measure another benefit: the value relevance of book values of earnings and equity in explaining market values of DAX-30 companies during the period 1995–2004. Using 265 observations, we find that adopting IFRS or US Generally Accepted Accounting Principles or cross-listing on the New York Stock Exchange significantly increases the value relevance of earnings relative to market prices.
Mirror, mirror on the wall… Who's the most opportunistic and compliant of them all?

Purpose - – The present research aims to revisit the relationships between buyer dependence on suppliers, relational norms between two parties in a buyer-supplier dyad, and a buyer's tendency to either engage in opportunistic behaviors or comply with a supplier's request as an exception condition. The authors adopt a supplier's perspective to examine the supplier's anticipation of the buyer's behaviors. Design/methodology/approach - – Based on the original studies conducted by Joshi and Arnold, the authors extend both works using a similar methodology but with a different data sample. The previously validated buyer-supplier relationship supply disruption scenario presented in the original studies is rewritten from a supplier's perspective to examine the supplier's anticipation of the buyer's behaviors. Subjects are asked to assume the role of an account manager within the key supplier firm for an electronic equipment manufacturer and to respond to how they deal with the supplier's expectation of how the buying firm may behave in terms of compliance and opportunism. Findings - – The results show that buyer dependence is positively related to buyer compliance behaviors and that this relationship holds irrespective of the buyer's or supplier's perspective on the supply disruption scenario and irrespective of professional or student subjects. Other findings include the contingency of the moderating effect of relational norms on the link between dependence and buyer compliance on various factors, and the existence of a boundary condition for the moderation effect of relational norms on the link between dependence and buyer opportunism. Originality/value - – The study should prove valuable to academics and professionals alike. It reinforces the notion that buyers that are more dependent and reliant on suppliers are more willing to comply with supplier's needs. Also, it considers the possibility that supply chain agents from both the buyer and supplier sides may value the effect of relational norms differently, with suppliers perceiving that relational norms have more of a direct influence on a buyer's behavior. Lastly, the replication study extends the understanding of the generalizability of the original studies.
Correlation of non‐uniform protein expression with variation in transmitter release probability

The strength of synaptic transmission is highly variable between different synapses. The present study examined some factors that may contribute to this variation in the strength of neurotransmission in sympathetic varicosities of the mouse vas deferens. Transmitter release was measured using a focal macropatch electrode placed over pairs of visualised varicosities. By regulating the calcium concentration of the solutions inside the recording electrode and in the bath independently of each other, transmitter release was restricted to one or two surface varicosities at each recording site. Using this technique, transmitter release probability was shown to be highly variable, even between adjacent varicosities on single axon branches. Very little variation was observed in the calcium influx following single impulse nerve stimulation between adjacent Oregon Green BAPTA‐1 loaded varicosities. However, the staining intensities of three vesicular proteins, SV2, synaptophysin, and synaptotagmin 1, showed considerable variation between adjacent varicosities on single axon branches. This variation in staining intensity may be partly explained by variation in the density of synaptic vesicles. However, double staining experiments using two vesicular antigens showed some varicosities staining for one vesicular antigen, but not for the second, suggesting that the expression of these release machinery proteins is regulated locally within the varicosities. The results of the present study strengthen suggestions that synaptic strength is at least in part, regulated by variation in the expression of vesicular proteins. Synapse 55:110–121, 2005. © 2004 Wiley‐Liss, Inc.
Significant Other Burden and Factors Related to it in Traumatic Brain Injury

Feelings of burden and factors related to it were examined in a sample of 180 relatives of moderately to severely traumatically brain injured (TBI) subjects 6 months postinjury. Relatives were enrolled onto the study based on their family member's head injury and not on outcome. The results indicate that although both positive and negative experiences were common, the majority of the relatives reported an overall positive experience. The significant other's (SO's) experience was significantly and systematically related to many factors with overall negative experience associated with increased brain injury severity, worse neuropsychological functioning, increased dependency on others, SO's report of changes in the TBI subject, changes in the SO's life as a result of caregiving and SO depression.
The Fundaments of Applying the Concept of Public Service Motivation in the South-Eastern European States

Public Service Motivation (PSM) is a relatively recent concept, defined for the first time in the 1990s in the United States by Perry and Wise as being the general predisposition of an individual to respond to motives, values which are to be encountered only in public institutions. These values, which represent the basis for the construction of PSM are not institutionalized in the same degree and in the same manner everywhere, which creates differences according to the specificity of the region, the state or the organizational environment. European studies regarding PSM have mainly focused on Western Europe: France, The Netherlands, Belgium. For this reason, in this article we aim to analyze the concept of PSM and set the basis for a thorough research in order to make it operational in the countries of South-Eastern Europe: Romania and Bulgaria. Thus, we wish to bring our own contribution to the development of a theoretical and methodological framework for PSM in Romania and in South-Eastern European countries. The objectives of the article focus on: formulating an exhaustive definition of the concept, analysing Perry's measurement scale based on 24 items and the relevance of these items in the above-mentioned countries, adapting/adjusting the measurement scale according to the national/regional specificities of the public service values.
Dendritic cell maturation and chemotaxis is regulated by TRPM2‐mediated lysosomal Ca2+ release

Chemokines induce calcium (Ca2+) signaling and chemotaxis in dendritic cells (DCs), but the molecular players involved in shaping intracellular Ca2+ changes remain to be characterized. Using siRNA and knockout mice, we show that in addition to inositol 1,4,5‐trisphosphate (IP3)‐mediated Ca2+ release and store‐operated Ca2+ entry (SOCE), the transient receptor potential melastatin 2 (TRPM2) channel contributes to Ca2+ release but not Ca2+ influx in mouse DCs. Consistent with these findings, TRPM2 expression in DCs is restricted to endolysosomal vesicles, whereas in neutrophils, the channel localizes to the plasma membrane. TRPM2‐deficient DCs show impaired maturation and severely compromised chemokine‐activated directional migration as well as bacterial‐induced DC trafficking to the draining lymph nodes. Defective DC chemotaxis is due to perturbed chemokine‐receptor‐initiated Ca2+ signaling mechanisms, which include suppression of TRPM2‐mediated Ca2+ release and secondary modification of SOCE. DCs deficient in both TRPM2 and IP3 receptor signaling lose their ability to perform chemotaxis entirely. These results highlight TRPM2 as a key player regulating DC chemotaxis through its function as Ca2+ release channel and confirm ADP‐ribose as a novel second messenger for intracellular Ca2+ mobilization. —Sumoza‐Toledo, A. , Lange, I. , Cortado, H. , Bhagat, H. , Mori, Y. , Fleig, A. , Penner, R. , Partida‐Sánchez, S. Dendritic cell maturation and chemotaxis is regulated by TRPM2‐mediated lysosomal Ca2+ release. FASEB J. 25, 3529–3542 (2011). www.fasebj. org
Significance of Neoplastic Involvement of Margins Obtained by Endoscopic Mucosal Resection in Barrett's Esophagus

OBJECTIVES:Although EMR has been used for elimination of neoplasia in BE, the significance of positive carcinoma margins and depth of invasion on endoscopic resection pathology has not been assessed using a valid standard. The aim of this study was to assess the accuracy of tumor staging by EMR using esophagectomy as the standard.METHODS:Medical records of patients, who underwent endoscopic resection for esophageal carcinoma or high-grade dysplasia in BE followed by esophagectomy, were reviewed. Data were abstracted from a prospectively maintained EMR database. Endosonography and endoscopic resection were performed by a single experienced endoscopist. Two experienced GI pathologists interpreted all histological results. Standard statistical tests were used to compare continuous and categorical variables.RESULTS:Twenty-five patients were included in the study. Three patients had mucosal carcinoma and 16 had submucosal carcinoma following endoscopic resection. Surgical pathology staging was consistent with preoperative EMR staging in all patients. No patient with negative mucosal resection margins had residual tumor at the resection site at esophagectomy. In patients with submucosal carcinoma, 8 had residual carcinoma at the EMR site at surgery and 5 patients had metastatic lymphadenopathy.CONCLUSIONS:Tumor staging using EMR pathology is accurate when compared with surgical pathology following esophagectomy. Negative margins on EMR pathology correlate with absence of residual disease at the EMR site at esophagectomy. Submucosal carcinoma on EMR specimens was associated with a high prevalence of residual disease at surgery (50%) and metastatic lymphadenopathy (31%).
Upper-Limb Discoordination in Hemiparetic Stroke: Implications for Neurorehabilitation

Abstract Clinically, upper-limb discoordination after stroke is evident in the form of stereotypic movement patterns that reflect a loss of independent joint control. These movement abnormalities, in conjunction with our recent quantitative findings under isometric conditions, provide evidence for an impaired capacity to generate certain muscle coactivation patterns in the impaired limb. In this article, we examine the parallels that exist between coordination disturbances observed under isometric and movement conditions. Our results suggest that discoordination in stroke may largely represent a manifestation of additional neural constraints on motor outflow. The neurotherapeutic implications of our findings are discussed.