Miracle-dz/UniFAR-FTUs huggingface dataset:
Peripheral Visions? A Cross-cultural Study of Rural Youths' Views on Migration

This study sets out to investigate anticipatory views concerning out-migration amongst rural youth. Utilising three age-group samples from rural Norway, Scotland and Sweden, young people were classified as prospective 'stayers', 'leavers' or 'returners'. Both qualitative and quantitative data show that 'stayers' see themselves as most contented with rurality. 'Leavers' are most negative to rural living. 'Returners', though also critical about rural living, are highly positive towards social relations in their communities. Furthermore, national and gender differences are evident. These varying adolescent constructions of rurality are discussed in relation to possible national policies.
Creativity and the Quantum: A Unified Theory of Creativity

ABSTRACT: Creativity theories are as diverse as the worldviews in which they are wrapped. Recently, an integrative science and an integrated worldview have been founded on two giant pillars of human thought—the philosophy of monistic idealism and quantum physics. In this article, a unification of the theories of creativity is accomplished based on this integrative science and worldview. New definitions for the phenomenon are proposed and justified. A theory of the creative process is formulated, and applications of the unified theory are briefly discussed.
Exploring Effective Dialogue Act Sequences in One-on-one Computer Science Tutoring Dialogues

We present an empirical study of one-on-one human tutoring dialogues in the domain of Computer Science data structures. We are interested in discovering effective tutoring strategies, that we frame as discovering which Dialogue Act (DA) sequences correlate with learning. We employ multiple linear regression, to discover the strongest models that explain why students learn during one-on-one tutoring. Importantly, we define "flexible" DA sequence, in which extraneous DAs can easily be discounted. Our experiments reveal several cognitively plausible DA sequences which significantly correlate with learning outcomes.
Electroencephalography/functional magnetic resonance imaging responses help predict surgical outcome in focal epilepsy

Simultaneous electroencephalography/functional magnetic resonance imaging (EEG/fMRI) recording can noninvasively map in the whole brain the hemodynamic response following an interictal epileptic discharge. EEG/fMRI is gaining interest as a presurgical evaluation tool. This study aims to determine how hemodynamic responses related to epileptic activity can help predict surgical outcome in patients considered for epilepsy surgery.
Comparative Pharmacophore Modeling of Organic Anion Transporting Polypeptides: A Meta-Analysis of Rat Oatp1a1 and Human OATP1B1

The organic anion transporting polypeptides OATPs are key membrane transporters for which crystal structures are not currently available. They transport a diverse array of xenobiotics and are expressed at the interface of hepatocytes, renal tubular cells, enterocytes, and the choroid plexus. To aid the understanding of the key molecular features for substrate-transporter interactions, pharmacophore models were produced for the two OATPs that have been most extensively studied, namely rat Oatp1a1 and human OATP1B1. Literature data from Chinese hamster ovary, HeLa, human embryonic kidney 293 cells, and Xenopus laevis oocytes were used to construct pharmacophores for each individual transporter which were later merged to show similarities across cell lines for the same transporter. Additionally, meta-pharmacophores were generated from the combined datasets of each cell system used with the same transporter. The pharmacophores for each transporter consisted of hydrogen bond acceptor and hydrophobic features. There was good agreement between the merged and meta-pharmacophores containing two hydrogen bond acceptors and two or three hydrophobic features for Oatp1a1 and OATP1B1. External test sets were used to validate the individual pharmacophores. The meta-pharmacophores were also used to make predictions for molecules not included in the models and provided new molecular insight into the key features for these OATP transporters. This approach can be extended to other transporters for which limited data are available.
Trirotor mechatronic design and reduction of dynamic model inputs by aerodynamic forces identification

This paper outlines a mechatronic design and a remote measurement system of a trirotor unmanned aerial vehicle (UAV). Furthermore, with particular emphasis on the experimental aspect, this study presents also a real dynamic model with reduced inputs made by experimental aerodynamic forces/torques identification. The trirotor presents a real control challenge compared with the quadrotor system. Indeed, in contrast to the quadrotor, the trirotor presents a non-symmetric structure and it has an odd number of rotors which causes a yaw moment issue. The developed mechanical design and the actuators characteristics are then presented. Experimental tests show that we can have a reduced dynamic model. Indeed, with empirical manipulations we deduce some relations between drag torque and thrust forces. Such result allows us to reduce the trirotor developed model inputs. Finally, this study is a preliminary phase before the real-time control implementation.
Dynamic Core Competences through Meta-Learning and Strategic Context

Traditional approaches to studying competitive advantage, while valuable, are not adequate to explain how firms can operate effectively in turbulent and often chaotic environments. A resource or skill-based view focusing on development and application of core competences is offered to supplement the traditional approaches. We present a model of the development and outcomes of dynamic core competences based on organizational meta-learning. A firm’s core competence(s) is defined as a set of problem-defining and problem-solving insights that fosters the development of idiosyncratic strategic growth alternatives. Dynamic core competences are based on the integration into systemic meta-learning of universal and tacit knowledge through information transfer, redefinition of heuristics and continuous improvement based on experimentation and the development of firm-specific skills based on dynamic routines. Dynamic core competences can be leveraged to create growth alternatives of global diversification, new applications of existing technologies and/or the development of new lines of business. Finally, dynamic core competences can be used to reduce uncertainty and to induce path dependencies that create causal ambiguity (making imitation from other firms difficult). In so doing, they can form the basis of competitive advantages.
In-Silico Modeling of the Mitotic Spindle Assembly Checkpoint

Background The Mitotic Spindle Assembly Checkpoint (MSAC) is an evolutionary conserved mechanism that ensures the correct segregation of chromosomes by restraining cell cycle progression from entering anaphase until all chromosomes have made proper bipolar attachments to the mitotic spindle. Its malfunction can lead to cancer. Principle Findings We have constructed and validated for the human MSAC mechanism an in silico dynamical model, integrating 11 proteins and complexes. The model incorporates the perspectives of three central control pathways, namely Mad1/Mad2 induced Cdc20 sequestering based on the Template Model, MCC formation, and APC inhibition. Originating from the biochemical reactions for the underlying molecular processes, non-linear ordinary differential equations for the concentrations of 11 proteins and complexes of the MSAC are derived. Most of the kinetic constants are taken from literature, the remaining four unknown parameters are derived by an evolutionary optimization procedure for an objective function describing the dynamics of the APC:Cdc20 complex. MCC:APC dissociation is described by two alternatives, namely the “Dissociation” and the “Convey” model variants. The attachment of the kinetochore to microtubuli is simulated by a switching parameter silencing those reactions which are stopped by the attachment. For both, the Dissociation and the Convey variants, we compare two different scenarios concerning the microtubule attachment dependent control of the dissociation reaction. Our model is validated by simulation of ten perturbation experiments. Conclusion Only in the controlled case, our models show MSAC behaviour at meta- to anaphase transition in agreement with experimental observations. Our simulations revealed that for MSAC activation, Cdc20 is not fully sequestered; instead APC is inhibited by MCC binding.
Team Effectiveness and Team Development in CSCL

There is a wealth of research on computer-supported cooperative work (CSCW) that is neglected in computer-supported collaborative learning (CSCL) research. CSCW research is concerned with contextual factors, however, that may strongly influence collaborative learning processes as well, such as task characteristics, team formation, team members’ abilities and characteristics, and role assignment within a team. Building on a critical analysis of the degree to which research on CSCW translates to CSCL, this article discusses the mediating variables of teamwork processes and the dynamics of learning-teams. Based on work-team effectiveness models, it presents a framework with key variables mediating learning-team effectiveness in either face-to-face or online settings within the perspective of learning-team development.
Prognostically useful gene-expression profiles in acute myeloid leukemia.

BACKGROUND In patients with acute myeloid leukemia (AML) a combination of methods must be used to classify the disease, make therapeutic decisions, and determine the prognosis. However, this combined approach provides correct therapeutic and prognostic information in only 50 percent of cases. METHODS We determined the gene-expression profiles in samples of peripheral blood or bone marrow from 285 patients with AML using Affymetrix U133A GeneChips containing approximately 13,000 unique genes or expression-signature tags. Data analyses were carried out with Omniviz, significance analysis of microarrays, and prediction analysis of microarrays software. Statistical analyses were performed to determine the prognostic significance of cases of AML with specific molecular signatures. RESULTS Unsupervised cluster analyses identified 16 groups of patients with AML on the basis of molecular signatures. We identified the genes that defined these clusters and determined the minimal numbers of genes needed to identify prognostically important clusters with a high degree of accuracy. The clustering was driven by the presence of chromosomal lesions (e.g., t(8;21), t(15;17), and inv(16)), particular genetic mutations (CEBPA), and abnormal oncogene expression (EVI1). We identified several novel clusters, some consisting of specimens with normal karyotypes. A unique cluster with a distinctive gene-expression signature included cases of AML with a poor treatment outcome. CONCLUSIONS Gene-expression profiling allows a comprehensive classification of AML that includes previously identified genetically defined subgroups and a novel cluster with an adverse prognosis.
Untersuchungen zur spezifischen Dauer deutscher Vokale

Abstract This paper examines the effects of vowel quality (formant frequencies), speaker and place of articulation of the surrounding consonants (/p/, /t/ or /k/) upon the duration of German vowels embedded in a fixed carrier sentence. The results obtained verify and complement known data from other investigations and make it possible to specify formulae, which can be used both in prosodic analysis and in automatic speech synthesis.
Economic Information Versus Quality Variation in Cross-Country Data

Data quality in the Penn World Tables varies systematically across countries that have different growth rates and at different stages of economic development, thus introducing measurement error correlated with variables of economic interest. We explore the seriousness of this problem with three examples from the literature, showing that the problem appears to be minor in growth convergence regressions but serious in estimating the effect of growth volatility on the average growth rate and in a cross-country test of the Permanent Income Hypothesis. The results suggest, at the very least, a need for performing appropriate sensitivity tests before drawing conclusions from analyses based on available cross-country data.
Development and Validation of a Work Domain Goal Orientation Instrument

This article describes the development and validation process for an instrument to assess goal orientation (an individual disposition toward developing or validating one's ability in achievement settings). In contrast to previous goal orientation instruments, three goal orientation dimensions are identified (learning, avoid, and prove), and the instrument is domain specific to work settings. The results of exploratory factor analysis, reliability analysis (internal consistency and test-retest), confirmatory factor analysis, and nomological network analysis all support the conclusion that the instrument operationalizes the theorized three-dimensional construct.
Update on genistein and thyroid: an overall message of safety

Genistein aglycone, one of the soy isoflavones, has been reported to be beneficial in the treatment of menopausal vasomotor symptoms, osteoporosis, and cardiovascular diseases, as well as in a variety of cancers. However, issues of potential harm on thyroid function resulting from soy isoflavones consumption have been raised. Much of the evidence for the goitrogenic effects of isoflavones is derived from experimental in vitro and in vivo studies. Goitrogenic effects were also noted in infants fed non-iodine-fortified, soy-based formula, a problem that was easily solved with iodine fortification. Recent studies suggest that genistein shows a good profile of safety on the thyroid although definitive conclusions have not reached. The aim of this brief review is to summarize and better clarify the effects of genistein on human thyroid health.
Jupiter’s decisive role in the inner Solar System’s early evolution

Significance The Solar System is an unusual member of the galactic planetary census in that it lacks planets that reside in close proximity to the Sun. In this work, we propose that the primordial nebula-driven process responsible for retention of Jupiter and Saturn at large orbital radii and sculpting Mars’ low mass is also responsible for clearing out the Solar System’s innermost region. Cumulatively, our results place the Solar System and the mechanisms that shaped its unique orbital architecture into a broader, extrasolar context. The statistics of extrasolar planetary systems indicate that the default mode of planet formation generates planets with orbital periods shorter than 100 days and masses substantially exceeding that of the Earth. When viewed in this context, the Solar System is unusual. Here, we present simulations which show that a popular formation scenario for Jupiter and Saturn, in which Jupiter migrates inward from a > 5 astronomical units (AU) to a ≈ 1.5 AU before reversing direction, can explain the low overall mass of the Solar System’s terrestrial planets, as well as the absence of planets with a < 0.4 AU. Jupiter’s inward migration entrained s ≳ 10−100 km planetesimals into low-order mean motion resonances, shepherding and exciting their orbits. The resulting collisional cascade generated a planetesimal disk that, evolving under gas drag, would have driven any preexisting short-period planets into the Sun. In this scenario, the Solar System’s terrestrial planets formed from gas-starved mass-depleted debris that remained after the primary period of dynamical evolution.
Abysmal prognosis of patients with type 2 diabetes entering dialysis.

INTRODUCTION The importance of non-insulin-dependent diabetes mellitus (type II diabetes) as a leading cause of end-stage renal disease is now widely recognized. The purpose of this study was to assess life-prognosis and its predictors in a cohort of patients newly entering dialysis. MATERIAL AND METHODS Eighty-four consecutive type II diabetes patients (40% of all patients) starting dialysis between 01/01/95 and 31/12/96 were studied retrospectively, focusing on clinical data at inception and life-prognosis after a mean follow-up of 211 days. Patients were divided into three groups, according to onset of renal failure: acute 11% (9/84), chronic 61% (51/84) and acutely aggravated chronic renal failure 28% (25/84). RESULTS Patients (mean age 67 years) had long-standing diabetes (mean duration approximately 15 years), heavy proteinuria (approximately 3 g/24h) and diabetic retinopathy (67%). The average creatinine clearance (Cockcroft's formula) was 13 ml/min. Cardiovascular diseases were highly prevalent at the start of dialysis: history of myocardial infarction (26%), angina (36%) and acute left ventricular dysfunction (67%). More than 80% of the patients underwent the first session dialysis under emergency conditions, a situation in part related to late referral to the nephrology division (63% for chronic patients). A great majority of the patients were overhydrated when starting dialysis, as evidenced by the average weight loss of 6 kg, during the first month of dialysis, required to reach dry weight. Nearly 64% of the patients presented high blood pressure (> 140/90 mmHg) when starting dialysis despite antihypertensive therapy (mean: 2.3 drugs). The outcome of this type II diabetes population was dramatic: 32% (27/84) died after a mean follow-up of 211 days, mostly from cardiovascular diseases. The rate of recovery of renal function was low in both the acute and the acutely aggravated renal failure group (30% and 24%, respectively). Of note, iatrogenic nephrotoxic agents accounted for renal function impairment in nearly 30% of patients. CONCLUSION Our observational study illustrates the high burden of cardiovascular diseases contrasting with sub-optimal cardiovascular therapeutic interventions in type II diabetes patients entering dialysis. Factors aggravating renal failure were mainly iatrogenic, and therefore largely avoidable. Late referral generally implied a poor clinical condition at the start of dialysis.
A 78.8–92.8 GHz 4-bit 0–360° active phase shifter in 28nm FDSOI CMOS with 2.3 dB average peak gain

A 78.8-92.8 GHz 4-bit (16 phases) digitally controlled vector modulator active phase shifter has been designed and implemented in 28nm FDSOI CMOS by STMicroelectronics. The phase shifter exploits a novel IQ generator based on a cascode amplifier incorporating a lumped element coupled line quadrature coupler to generate the in-phase (I) and quadrature (Q) signals. The phase shifter consumes 18 mA from a 1.2 V supply. The measured performances are: average gain of 2.3 dB at 87.4 GHz (between 3.2 and -1.6 dB for the 16 phase states) and -3 dB bandwidth (B3dB) from 78.8 to 92.8 GHz; RMS gain error equal to 1.68 dB at 87.4 GHz and lower than 2 dB in the B3dB; RMS phase error equal to 9.4o at 87.4 GHz and lower than 11.9o in the B3dB; S11 lower than -10.5 dB in the B3dB; average input referred 1 dB compression point of -7 dBm (between -8 and -5 dBm for the 16 phase states); average noise figure equal to 10.8 dB at 87 GHz (between -9 and -12 dB for the 16 phase states).
Predictors of Flexibility in Social Identity Among People Entering a Therapeutic Community for Substance Abuse

One of the key aspects of recovery from substance dependence is making a transition from a social network supportive of substance use to one that supports recovery. This study assessed this transition in social identity in an adult therapeutic community (TC) at baseline and 2 weeks into treatment. Where residents increased identification with the TC, and reduced social identification with using groups, retention in treatment improved. As retention is a proxy measure of positive outcomes, this pilot suggests that facilitating residents' positive identification with the community in the first weeks of treatment may be central to retaining residents and improving treatment outcomes.
International Conference on Information Systems ( ICIS ) 1-1-2010 Information Sharing When Firms Compete for Common-Value Customers

Extant research suggests that the sharing of individual-level customer information benefits competing firms by allowing them to better discriminate their customers and soften the price competition. This paper shows that the information sharing may benefit competing firms even without price discrimination. Based on a common-value auction framework, the paper studies the case where two firms compete head-to-head for common-value customers who have no brand preference. Firms differ in their information about the customers’ preferences on the product/service. Our model illustrates that the better informed firm would like to sell its customer data to the competitor when the data reveals more valuable customers and when the information asymmetry between firms is large. The model also examines the optimal degree of information sharing between firms. The insights from this study complement the extant literature in illustrating how information sharing allows firms to better profit from different types of customers.
A Review on the Relationship between Organizational Culture and Performance

Abstract The performance of organizational culture effectiveness has been supported by several researchers. Since Peters & Waterman acclaimed that the excellent companies have their unique culture type, the effectiveness of organization culture have been practically supported. Organization culture is closely related to employees' satisfaction and commitment and contributed to the subjective performance and financial performance in terms of individual and organizational level. Organizational culture is a valuable resources and competitive advantage for the successful growth. Thefore, I have proposed some proposition regarding the type and strength of organization culture and the interaction effect of internal consistency which should be studied for more fundamental study of the effectiveness of organizational culture. Key Words : Organization Culture, Culture Strength, Organization Culture and Performance 1. 서론 조직문화(organizational culture)의 조직성과에 대한 유효성은 지난 수십 년간 많은 연구들에서 지지되어 왔다. 우수기업들에서 공통적으로 나타나는 문화적 특성들이 존재한다는 사실을 확인한 Peters & Waterman[47]의 연구 이후, 동서양을 막론하고 수많은 연구들에서 조직문화는 조직의 효과성에 기여하는 것으로 실증되고 있다 . 조직문화는 조직 구성원의 만족이나 몰입 등의 개인 수준의 조직유효성과 밀접한 관련성을 가지고 있으며[1,2,6,14,15,25,34,40,42], 개인성과뿐만 아니라 조직 수준의 주관적 성과 및 재무적 성과에도 기여를 하는 것으로 나타났다[4,27,30,32,34,40,63]. 이와 같이, 조직문화는 조직의 성과에 기여하는 가치 있는 자원일 뿐만 아니라 희소하며, 인과적으로 모호하여 다른 조직이 모방하기 어렵기 때문에 조직의 지속적인 경쟁우위의 원천으로 간주되
Antecedents of Moral Pride: the Harder the Action, the Greater the Pride?

Abstract The study’s aim was to analyze if some specific types of action generate higher levels of moral pride. Three variables were analyzed: whether the actions involved going against the group majority, whether they involved a personal cost of a different kind and whether they were the result of a prior intention. Participants were 160 adolescents aged between 14 and 16. Sixteen scenarios were designed (two for each combination of the three variables) in which someone needed help. Half of the participants were presented with 8 of these scenarios, and half with the other 8. In each scenario, participants were asked to state what they would feel and do and how much pride they would feel if they helped. Curiously enough, both prosocial behaviors which involved going against the majority, F(1, 140) = 60.36, p = . 001, η2 = . 301 and those which involved a personal cost of a different kind, F(1, 140) = 10.17, p = . 002, η2 = . 068 generated less moral pride.