Miracle-dz/UniFAR-FTUs huggingface dataset:
Regulatory mechanisms in cell-mediated immune responses. VI. Interaction of H-2 and non-H-2 genes in elaboration of mixed leukocyte reaction suppressor factor

Previous studies have shown that alloantigen-activated spleen T cells produce a soluble factor which suppresses mixed lymphocyte reaction proliferative responses, and that the interaction between suppressor and responder cells is controlled by genes of the H-2 complex. However a defect in the expression of suppressor activity was identified in the mouse strain C57BL/6J. Factor prepared from alloactivated B6 spleen cells failed to suppress MLR responses of syngeneic or H-2 compatible responder cells. Unimpaired suppressor factor production by other H-2 (b) strains and failure of suppressor factor production by a B6 congenic strain, B6.C-H-2(d) isolated the defective gene to the non-H-2 portion of the genome. In addition, the defect appeared to be related specifically to inability to produce an active factor, while the capacity to respond to suppressor molecules was unimpaired. The genetic character of the non-H-2 gene action was identified in F1 hybrid studies. Initially F(1) hybrids of the nondefective histoincompatible strains were studied. Suppressor factor from F1 cells suppressed the responses of both parental strains, and parental factors each suppressed the response of F(1) cells. Adsorption of F(1) factor with Con A-activated thymocytes of either parental strain removed suppressor activity specific for that strain, leaving activity against the other parental strain intact. The data support cedominant expression and production of distinct, parental H-2 haplotype-specific suppressor molecules by F(1) suppressor cells. An F(1) hybrid of the defective B6 strain with nondefective BALB/c produced suppressor factor which was also capable of suppressing both parental strains. Production of a suppressive B6-reactive factor by F(1) cells was verified by adsorption studies. Thus it appears that non-H-2 genes of the BALB/c parent acted in a genetically dominant fashion to provide the function required for expression of B6 suppressor molecules. We conclude that multiple genes control the expression of alloactivated suppressor cell activity, with at least one gene mapped to the I-C subregion of the murine major histocompatibility complex and one or more genes mapped to the non-H-2 gene complement.
Self-directed Learning Readiness of College Students in Thailand

In the knowledge-based society, where information rapidly changes and disseminates worldwide, self-directed learning is an important ability for college students to possess. In the current study, self-directed learning readiness of college students in Thailand was investigated, and comparisons of this readiness were made across years of education and majors. Undergraduate students (n = 156) in colleges of education in Thailand completed an online survey. The results revealed that Thai college students reported having self-directed learning readiness at a moderate to high level. The two dimensions (creativity and openness to learning) were at a moderate level, but the other six dimensions were at a high level. Also, self-directed learning readiness differed across years of education and majors. Implications of how to maximize learning opportunity based on current circumstances were also provided.
On the Electrical Origin of Flicker Noise in Vacuum Devices

We have recently shown that thermal noise in the space-charge regions of solid-state devices can account for most of their excess noise, whose 1/f spectrum is produced by the DC bias that was used to convert resistance noise into a voltage noise to be measured. This spectrum reflects the modulation of an energy barrier that confines carriers along the channel of such devices-a feature that was also found for electrons around cathodes of vacuum tubes. Using this novel theory, we can predict a flicker noise in vacuum tubes-a noise whose origin has eluded scientists since its early report by Johnson in 1925.
Children's expressive drawing strategies: the effects of mood, age and topic

The study aimed to investigate whether the impact of mood state on children's choice of expressive strategies (literal and non-literal content and abstract) varies as a function of mood valence, age and topic to be drawn. The sample (N = 96) consisted of four groups of children aged 5, 7, 9 and 11years, respectively. Half of the children in each age group were induced with a positive mood state and the other half with a negative mood state. Following mood induction, children were asked to draw one of two topics, an animate (person) or an inanimate one (tree). The results showed that: (a) happiness and sadness activated similar expressive drawing strategies; (b) from the age of five years onwards children were able to use both literal and non-literal expressive strategies in their drawings; (c) non-literal content strategies were used more frequently compared to abstract ones by all age groups; and (d) topic had an effect on the choice of expressive strategies: children used more literal strategies for the depiction of the person and more non-literal ones for the depiction of the tree. The implications of these findings and future directions for research are discussed.
Islamic values: a distinctive framework for moral education?

The first half of this Editorial examines the implications of the close link between morality and religion in Islamic thinking. There is no separate discipline of ethics in Islam, and the comparative importance of reason and revelation in determining moral values is open to debate. For most Muslims, what is considered halāl (permitted) and harām (forbidden) in Islam is understood in terms of what God defines as right and good. There are three main kinds of values: (a) akhlāq, which refers to the duties and responsibilities set out in the shari‘ah and in Islamic teaching generally; (b) adab, which refers to the manners associated with good breeding; and (c) the qualities of character possessed by a good Muslim, following the example of the Prophet Muhammad. Among the main differences between Islamic and western morality are the emphasis on timeless religious principles, the role of the law in enforcing morality, the different understanding of rights, the rejection of moral autonomy as a goal of moral education and the stress on reward in the Hereafter as a motivator of moral behaviour. The remainder of the Editorial is concerned with the two main aspects of moral education in Islam: disseminating knowledge of what people should and should not do, and motivating them to act in accordance with that knowledge. Ultimately, moral education is about inner change, which is a spiritual matter and comes about through the internalisation of universal Islamic values.
LEARNING AND DOING: THE IMPORTANCE OF SERVICE-LEARNING IN GERONTOLOGY

Service-learning is an approach to teaching and learning that has great potential for gerontology. The articles in this special issue present a wealth of conceptual and practical information about how to create service-learning opportunities, manage them effectively, and evaluate them appropriately. This article identifies several common themes in the articles and offers an administrative perspective on the role and value of service-learning.
Cognition and Improvisation: Differences in Mathematics Instruction by Expert and Novice Teachers

This study investigates the nature of pedagogical expertise by comparing the planning, teaching, and postlesson reflections of three student teachers (two secondary and one elementary) with those of the cooperating teachers with whom they were placed. Participants were observed teaching mathematics for 1 week of instruction and were interviewed prior to and following each lesson. Differences in the thinking and actions of these experts and novices were analyzed by perceiving teaching both as a complex cognitive skill and as improvisational performance Novices showed more time-consuming, less efficient planning, encountered problems when attempts to be responsive to students led them away from scripted lesson plans, and reported more varied, less selective postlesson reflections than experts. These differences were accounted for by the assumptions that novices’ cognitive schemata are less elaborate, interconnected, and accessible than experts’ and that their pedagogical reasoning skills are less well developed. We offer several recommendations for student teaching based on this analysis.
Effect of propranolol and phenothiazines on electrodermal orienting and habituation in schizophrenia

SYNOPSIS Bilateral electrodermal orienting responses were measured to repeated auditory stimuli in schizophrenic patients and controls. In 3 studies phasic activity to moderate intensity sounds of patients on no drugs or phenothiazines was predominantly hyper- or hypo-responsive. Controls showed moderate or slow habituation. Propranolol was found to facilitate habituation in slow habituators and to reinstate responses in half of non-responders, especially when given as the sole drug. The effects seldom had a counterpart in changes in non-specific responses or levels of skin conductance. Modulatory influences on stimulus and response processing and on lateral asymmetries in responses may underlie propranolol's efficacy in treating schizophrenia.
Effect of Server Introduction on Restaurant Tipping1

The effect of a server introducing herself by name on restaurant tipping was investigated. Forty-two, 2-person dining parties were randomly assigned to either a name or a no name introduction condition. The use of a buffet brunch reduced contact between server and diners and held bill size constant. Results indicated that having the server introduce herself by name resulted in a significantly higher tipping rate (23.4%) than when the server did not introduce herself by name (15.0%), p < . 001. Tipping rate also was affected by method of payment, with diners who charged the meal having a higher rate (22.6%) than those paying cash (15.9%), p < . 001. The findings suggest the importance of initial server-diner interactions. Possible alternative explanations and suggestions for future research are provided.
Genetic variation in cell cycle regulatory gene AURKA and association with intrinsic breast cancer subtype

AURKA is a putative low‐penetrance tumor susceptibility gene due to its prominent role in cell cycle regulation and centrosomal function. Germline variation in AURKA was evaluated for association with breast cancer and intrinsic breast cancer subtypes in the Carolina Breast Cancer Study (CBCS), a population‐based case‐control study of African Americans (AA) and Caucasians (Cau). Tag and candidate single nucleotide polymorphisms (SNPs) on AURKA were genotyped in 1946 cases and 1747 controls. In race‐stratified analyses adjusted for age and African ancestry, odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to evaluate SNP associations with breast cancer. In a race‐combined analysis with similar adjustment, these associations were also examined by intrinsic breast cancer subtype. Using dominant models, most AURKA SNPs demonstrated no association with breast cancer in the race‐stratified analyses. Among AA, rs6092309 showed an inverse association with breast cancer (OR = 0.69, 95% CI = 0.53–0.90). In the race‐combined analyses, rs6099128 had reduced ORs for luminal A (OR = 0.76, 95% CI = 0.60–0.95) and basal‐like breast cancer (OR = 0.54, 95% CI = 0.37–0.80). Rs6092309 showed a similar pattern of association with each subtype. Three SNPs (rs6014711, rs911162, rs1047972) had positive associations with basal‐like breast cancer, and ORs reduced or close to 1.00 for other subtypes. Our results suggest inverse associations between some AURKA SNPs and overall breast cancer in AA. We found differential associations by specific subtypes and by race. Replication of these findings in larger AA populations would allow more powerful race‐stratified subtype analyses. © 2014 Wiley Periodicals, Inc.
Characterization of the Priming Effect by Pituitary Canine Growth Hormone on Canine Polymorphonuclear Neutrophil Granulocyte Function

ABSTRACT In this report, we demonstrate that canine growth hormone (cGH) is capable of priming canine polymorphonuclear neutrophil granulocytes (PMN) in a manner resembling that of human PMN. The cGH influences important functions that are involved in the process of recruitment of PMN, i.e., shape change, chemotaxis, CD11b/CD18 expression, adhesion, and subsequent transendothelial migration. Also, intracellular O2− production was evaluated. We investigated the priming effect by incubating PMN with purified pituitary cGH at various concentrations (10 to 800 μg/liter). The capacity for shape change was significantly (P < 0.05) enhanced, whereas the chemotactic response under agarose was significantly (P < 0.05) reduced. The chemotactic migration in Boyden chambers (10-μm-thick polycarbonate filter; lower surface count technique) was significantly (P < 0.05) enhanced, presumably due to cGH-induced hyperadhesiveness to the lower surface of the filters. The adhesion in albumin-coated microtiter plates and adherence to canine pulmonary fibroblasts were significantly (P < 0.05) increased, and the increased adhesion resulted in a significant (P < 0.01) increase in transendothelial migration using canine jugular vein endothelial cells. The increase in adhesion was associated with a significant increase in CD11b/CD18 expression. Furthermore, intracellular O2− production was significantly enhanced in response to both phorbol myristate acetate (P < 0.01) and opsonized zymosan (P < 0.05). In the absence of a PMN-stimulating agent, cGH did not influence the effector functions investigated except for an increased expression of CD11b/CD18.
The effect of prenotification techniques on refusal rate in telephone surveys: A real-life study in light of the Compliance and Elaboration Likelihood Theories

Response rate is of great importance for the representativeness of a study. When it is low, there is a chance that response is selective, as the people who refuse may constitute a selective sample of the target population. Much research has already been done into the sociopsychological aspects affecting response, but so far little attention has been paid to the effect of different communicative approaches. In our study we examine the effects of a two-phased communication plan on refusal rate in telephone surveys. In real-life experiments, we investigated the effects of two prenotification techniques: sending advance letters and leaving a message on an answeringmachine or voice mail. Sending advance letters led to a statistically significant decrease in refusals by 25%, but leaving a message on answering machines or voice mail led to no statistically significant decrease in refusals. The results are interpreted in the light of Compliance Theory and Elaboration Likelihood Theory. Possible consequences for research bureaus that conduct telephone surveys are discussed.
Design of an optimal nearest neighbor classifier using an intelligent genetic algorithm

The goal of designing an optimal nearest-neighbor classifier is to maximize the classification accuracy while minimizing the sizes of both the reference and feature sets. A novel intelligent genetic algorithm (IGA), which is superior to conventional genetic algorithms (GAs) in solving large parameter optimization problems, is used to effectively achieve this goal. It is shown empirically that the IGA-designed classifier outperforms existing GA-based and non-GA-based classifiers in terms of classification accuracy and the total number of parameters of the reduced sets.
Long-Term Sertraline Intake Reverses the Behavioral Changes Induced by Prenatal Stress in Rats in a Sex-Dependent Way

Early life stress is a major factor underlying the vulnerability to respond to stressful events later in life. The present study attempted to evaluate the role of prenatal stress affecting the development of stress-related disorders and their reversion by postnatal exposure to Sertraline (SERT), a front-line medication for medication for posttraumatic stress disorder (PTSD) in humans. To achieve this, adult male and female prenatally stressed (PS) or unstressed (Controls) offspring rats, following oral chronic treatment with SERT (5 mg/kg/day; from 1 month to 4 months old), or not, were studied prior to and after a traumatic event. First, anxiety-like behavior during the prepulse inhibition (PPI) test, a modulation of the startle reflex, was examined in all animals. Subsequently, the animals were subjected to a session of mild inescapable footshocks (IS; 0.35 mA, 5 s) in a shuttle box that was followed by 4 days of situational reminders in the aversive context. Prior to the footshocks no effects of PS or SERT were shown, and no changes in PPI and the habituation to the shuttle box were found. After them, PS led animals to exhibit behavioral alterations. When compared to the Controls, PS animals of both sexes displayed less rearing activity in the aversive environment. PS males responded less to footshock delivery and, in most of the animals, fear extinction was impaired. Moreover, the early postnatal exposure to SERT lessened the behavioral impact of PS in females, while in males it had no effect. Current results extend previous data from our laboratory, showing that PS heightened vulnerability to stress later on, and that SERT acts differently in males and females.
Locus of control, attributions and impression management in the selection interview

Surprisingly little is known about the ways in which candidates create positive impressions during employment interviews. Three studies are presented which investigate how candidate and interviewer locus of control influence preferences for three categories of explanations proffered by candidates during graduate recruitment interviews. In Study 1, we asked 139 undergraduate students and 37 personnel managers to rate internal-controllable, internal-uncontrollable and externaluncontrollable candidate attributions for hypothetical past events according to the likelihood of each producing a positive impression during a selection interview. Students also completed Rotter's Locus of Control questionnaire and the Interview Behaviour Scales. Students and personnel managers rated internal-controllable attributions most likely to create a positive impression. However, students with an external LoC rated external-uncontrollable explanations and internal-controllable explanations as being equally likely to convey a positive impression. In Study 2 a group of 62 candidates applying for actual positions with a company completed the same attribution questionnaire prior to first-stage interviews. Interviewer ratings of candidate performance correlated positively with ratings of internal-controllable explanations (r =.36, p< .001). In Study 3, a sample of 103 experienced interviewers completed the attribution questionnaire and the WLOC. All interviewers rated internal-controllable attributions most likely to convey a positive impression of a candidate. However, locus of control mediated preference for candidate attributions such that ‘External’ interviewers rated external-uncontrollable attributions significantly more likely to convey a positive impression than ‘Internal’ interviewers. The implications of these findings for impression management and interview selection decisions are discussed.
Cocoa Phenolic Extract Protects Pancreatic Beta Cells against Oxidative Stress

Diabetes mellitus is associated with reductions in glutathione, supporting the critical role of oxidative stress in its pathogenesis. Antioxidant food components such as flavonoids have a protective role against oxidative stress-induced degenerative and age-related diseases. Flavonoids constitute an important part of the human diet; they can be found in most plant foods, including green tea, grapes or cocoa and possess multiple biological activities. This study investigates the chemo-protective effect of a cocoa phenolic extract (CPE) containing mainly flavonoids against oxidative stress induced by tert-butylhydroperoxide (t-BOOH) on Ins-1E pancreatic beta cells. Cell viability and oxidative status were evaluated. Ins-1E cells treatment with 5–20 μg/mL CPE for 20 h evoked no cell damage and did not alter ROS production. Addition of 50 μM t-BOOH for 2 h increased ROS and carbonyl groups content and decreased reduced glutathione level. Pre-treatment of cells with CPE significantly prevented the t-BOOH-induced ROS and carbonyl groups and returned antioxidant defences to adequate levels. Thus, Ins-1E cells treated with CPE showed a remarkable recovery of cell viability damaged by t-BOOH, indicating that integrity of surviving machineries in the CPE-treated cells was notably protected against the oxidative insult.
Plasma homocyst(e)ine concentration, but not MTHFR genotype, is associated with variation in carotid plaque area.

BACKGROUND AND PURPOSE Elevated plasma homocyst(e)ine [H(e)] concentration is associated with premature atherosclerosis. A common cause of elevated plasma H(e) concentration is a thermolabile mutation (677T) in the gene encoding methylenetetrahydrofolate reductase (MTHFR). We sought to determine whether plasma H(e) concentration or MTHFR genotype would be more strongly associated with carotid plaque area (CPA), a potential intermediate phenotype of atherosclerosis. METHODS In 307 subjects who were ascertained through a premature atherosclerosis clinic, we measured CPA with 2-dimensional ultrasound and also determined traditional atherosclerosis risk factors, in addition to plasma H(e) concentration and MTHFR genotypes. RESULTS We found that the frequency of the MTHFR 677T allele was 0.363 in this sample. Mean plasma H(e) concentration was significantly higher in 677T/T homozygotes than in 677T/C heterozygotes and 677C/C homozygotes (17. 1+/-13.7 versus 13.5+/-6.1 versus 12.6+/-5.9 micromol/L, respectively, P<0.001). Analysis of variance showed that CPA was significantly associated with age, sex, smoking, diabetes, hypertension, and hyperlipidemia (each P<0.05). When plasma H(e) concentration was included in the model, it was significantly associated with CPA (P<0.05). However, when the MTHFR genotype was included in the model, it was not associated with CPA (P=0.50). Furthermore, there was a significant correlation of CPA with plasma H(e) (r=0.23, P<0.0001). However, the mean CPA did not differ between subjects according to genotype. CONCLUISONS: Thus, plasma H(e), but not MTHFR genotype, is significantly associated with carotid atherosclerosis, suggesting that the biochemical test may be sufficient to identify patients who may be at increased risk of atherosclerosis through this mechanism.
A Validation of Elements, Methods, and Barriers to Inclusive High School Service-Learning Programs

A statewide survey of coordinators of inclusive high school service-learning programs was conducted to validate elements, methods, and barriers to including students with and without disabilities in service-learning. Surveys were mailed to 655 service-learning coordinators; 190 (29%) returned a completed survey. Findings support the validity of the elements and methods. Respondents consistently rated the elements and methods higher in importance than actual use. Few barriers were identified although some individual respondents reported extreme barriers. Lack of money and time to co-plan were the greatest barriers shared across respondents. School size, presence of a service-learning graduation requirement, and inclusion of students with intellectual disability did not account for significant differences among service-learning coordinators.