Miracle-dz/UniFAR-FTUs huggingface dataset:
IL-33 activates tumor stroma to promote intestinal polyposis

Significance Colorectal cancer results from genetic lesions in epithelial cells. However, the tumor microenvironment, which is formed by nonepithelial stromal cells, also plays an important role in this disease. The influence of the microenvironment on tumorigenesis is mediated by paracrine signals between tumor epithelial cells and neighboring stromal cells. We found that expression of interleukin 33 (IL-33), an important mediator of type 2 immunity and wound repair, is induced in epithelial cells of human and mouse intestinal tumors. IL-33 promoted intestinal tumorigenesis in ApcMin/+ mice and activated two stromal cell types, subepithelial myofibroblasts and mast cells, known to mediate intestinal dysplasia. Tumor epithelial cells are proposed to coopt IL-33–mediated immune and wound-healing responses to create a microenvironment favorable to tumorigenesis. Tumor epithelial cells develop within a microenvironment consisting of extracellular matrix, growth factors, and cytokines produced by nonepithelial stromal cells. In response to paracrine signals from tumor epithelia, stromal cells modify the microenvironment to promote tumor growth and metastasis. Here, we identify interleukin 33 (IL-33) as a regulator of tumor stromal cell activation and mediator of intestinal polyposis. In human colorectal cancer, IL-33 expression was induced in the tumor epithelium of adenomas and carcinomas, and expression of the IL-33 receptor, IL1RL1 (also referred to as IL1-R4 or ST2), localized predominantly to the stroma of adenoma and both the stroma and epithelium of carcinoma. Genetic and antibody abrogation of responsiveness to IL-33 in the ApcMin/+ mouse model of intestinal tumorigenesis inhibited proliferation, induced apoptosis, and suppressed angiogenesis in adenomatous polyps, which reduced both tumor number and size. Similar to human adenomas, IL-33 expression localized to tumor epithelial cells and expression of IL1RL1 associated with two stromal cell types, subepithelial myofibroblasts and mast cells, in ApcMin/+ polyps. In vitro, IL-33 stimulation of human subepithelial myofibroblasts induced the expression of extracellular matrix components and growth factors associated with intestinal tumor progression. IL-33 deficiency reduced mast cell accumulation in ApcMin/+ polyps and suppressed the expression of mast cell-derived proteases and cytokines known to promote polyposis. Based on these findings, we propose that IL-33 derived from the tumor epithelium promotes polyposis through the coordinated activation of stromal cells and the formation of a protumorigenic microenvironment.
Evaluation Strategies for Planning as Satisfiability

We investigate different evaluation strategies for planning problems represented as constraint satisfaction or satisfiability problems. The standard evaluation strategy, evaluating the formulae by sequentially increasing the length one step at a time, guarantees that a plan corresponding to the first satisfiable formula is found first, yet this is often not the best possible strategy in terms of runtime. We present evaluation strategies based on parallel or interleaved evaluation of several formulae and show that with many problems this leads to substantially improved runtimes, sometimes several orders of magnitude. The cost of the improved runtimes is a possible decline in plan quality because an optimality guarantee of the standard evaluation strategy is lost.
Insomnia, Excessive Sleepiness, Excessive Fatigue, Anxiety, Depression and Shift Work Disorder in Nurses Having Less than 11 Hours in-Between Shifts

Study objective To assess if less than 11 hours off work between work shifts (quick returns) was related to insomnia, sleepiness, fatigue, anxiety, depression and shift work disorder among nurses. Methods A questionnaire including established instruments measuring insomnia (Bergen Insomnia Scale), sleepiness (Epworth Sleepiness Scale), fatigue (Fatigue Questionnaire), anxiety/depression (Hospital Anxiety and Depression Scale) and shift work disorder was administered. Among the 1990 Norwegian nurses who participated in the study; 264 nurses had no quick returns, 724 had 1–30 quick returns and 892 had more than 30 quick returns during the past year. 110 nurses did not report the number of quick returns during the past year. The prevalence of insomnia, excessive sleepiness, excessive fatigue, anxiety, depression and shift work disorder was calculated within the three groups of nurses. Crude and adjusted logistic regression analyses were performed to assess the relation between quick returns and such complaints. Results We found a significant positive association between quick returns and insomnia, excessive sleepiness, excessive fatigue and shift work disorder. Anxiety and depression were not related to working quick returns. Conclusions There is a health hazard associated with quick returns. Further research should aim to investigate if workplace strategies aimed at reducing the number of quick returns may reduce complaints among workers.
Fuzzy sets predict flexural strength and density of silicon nitride ceramics

In this work, we utilize fuzzy sets theory to evaluate and make predictions of flexural strength and density of NASA 6Y silicon nitride ceramic. Processing variables of milling time, sintering time, and sintering nitrogen pressure are used as an input to the fuzzy system. Flexural strength and density are the output parameters of the system. Data from 273 Si3N4 modulus of rupture bars tested at room temperature and 135 bars tested at 1370 C are used in this study. Generalized mean operator and Hamming distance are utilized to build the fuzzy predictive model. The maximum test error for density does not exceed 3.3 percent, and for flexural strength 7.1 percent, as compared with the errors of 1.72 percent and 11.34 percent obtained by using neural networks, respectively. These results demonstrate that fuzzy sets theory can be incorporated into the process of designing materials, such as ceramics, especially for assessing more complex relationships between the processing variables and parameters, like strength, which are governed by randomness of manufacturing processes.
Rate-Distortion Function for a Heegard-Berger Problem With Two Sources and Degraded Reconstruction Sets

In this paper, we investigate an instance of the Heegard-Berger problem with two sources and arbitrarily correlated side information sequences at two decoders, in which the reconstruction sets at the decoders are degraded. Specifically, two sources are to be encoded in a manner that one of the two is reproduced losslessly by both the decoders, and the other is reproduced within some prescribed distortion level at one of the two decoders. We establish a single-letter characterization of the rate-distortion function for this model. In particular, we show that the optimal coding scheme for this setting is one in which the common description to be recovered by both the decoders should allow to involve all or part of the source that is to be reproduced at only one decoder. Furthermore, we also generalize our result to the setting in which the source component that is to be recovered by both users is reconstructed in a lossy fashion, under the requirement that all terminals (i.e., the encoder and both the decoders) can share an exact copy of the compressed version of this source component, i.e., a common encoder-decoder reconstruction constraint. For this model as well, we establish a single-letter characterization of the associated rate-distortion function.
The Synaptic Organization of the Claustral Projection to the Cat's Visual Cortex

The claustrum is a subcortical structure reciprocally connected with most areas of neocortex. This strategic location suggests an integrative role of the claustrum across different sensory modalities. However, our knowledge of the synaptic relationship between the neocortex and the claustrum is basic. In this study, we address this question through a structural investigation of the claustral projection to the ipsilateral primary visual cortex of the cat. Light microscopic reconstructions of axons from the entire thickness of cortex showed a very sparse innervation of the entire cortical depth, with most synaptic boutons in layers 2/3 and 6. Axons bearing numerous boutons terminaux and boutons en passant branched in these laminae. The sparse innervation did not seem to be compensated by particularly large synapses, given that the postsynaptic densities in the superficial layers are of comparable sizes (0.1 μm2) to other cortical synapses. All claustral synapses were asymmetric and in most cases targeted spines (87% in layer 4, 94% in layers 2/3 and 97% in layer 6). The pattern of innervation together with the known physiology of this projection suggests that the claustrum has a modulatory effect on visual cortex.
Nasopharyngeal Bacterial Colonization and Gene Polymorphisms of Mannose-Binding Lectin and Toll-Like Receptors 2 and 4 in Infants

Background Human nasopharynx is often colonized by potentially pathogenic bacteria. Gene polymorphisms in mannose-binding lectin (MBL), toll-like receptor (TLR) 2 and TLR4 have been reported. The present study aimed to investigate possible association between nasopharyngeal bacterial colonization and gene polymorphisms of MBL, TLR2 and TLR4 in healthy infants. Methodology/Principal Findings From August 2008 to June 2010, 489 nasopharyngeal swabs and 412 blood samples were taken from 3-month-old healthy Finnish infants. Semi-quantitative culture was performed and pyrosequencing was used for detection of polymorphisms in MBL structural gene at codons 52, 54, and 57, TLR2 Arg753Gln and TLR4 Asp299Gly. Fifty-nine percent of subjects were culture positive for at least one of the four species: 11% for Streptococcus pneumoniae, 23% for Moraxella catarrhalis, 1% for Haemophilus influenzae and 25% for Staphylococcus aureus. Thirty-two percent of subjects had variant types in MBL, 5% had polymorphism of TLR2, and 18% had polymorphism of TLR4. Colonization rates of S. pneumoniae and S. aureus were significantly higher in infants with variant types of MBL than those with wild type (p = .011 and p = .024). Colonization rates of S. aureus and M. catarrhalis were significantly higher in infants with polymorphisms of TLR2 and of TLR4 than those without (p = .027 and p = .002). Conclusions Our study suggests that there is an association between nasopharyngeal bacterial colonization and genetic variation of MBL, TLR2 and TLR4 in young infants. This finding supports a role for these genetic variations in susceptibility of children to respiratory infections.
Scoped types for real-time Java

A memory model based on scoped areas is one of the distinctive features of the Real-Time Specification for Java (RTSJ). Scoped types ensure timely reclamation of memory and predictable performance. The price to pay for these benefits is an unfamiliar programming model that, at the same time, is complex, requires checking all memory accesses, and rewards design-time errors with run-time crashes. We investigate an alternative approach, referred to as scoped types, that simplifies the task of managing memory in real-time codes. The key feature of our proposal is that the run-time partition of memory imposed by scoped areas is straightforwardly mirrored in the program text. Thus cursory inspection of a program reveals which objects inhabit the different scopes, significantly simplifying the task of understanding real-time Java programs. Moreover, we introduce a type system which ensures that no run-time errors due to memory access checks occur. Thus a RTSJ-compliant virtual machine does not require memory access checks. The contributions of this paper are the concept of scoped types, and a proof soundness of the type system. Experimental results are described in future work.
A Critical Role for Cd40–Cd40 Ligand Interactions in Amplification of the Mucosal Cd8 T Cell Response

The role of CD40 ligand (CD40L) in CD8 T cell activation was assessed by tracking antigen-specific T cells in vivo using both adoptive transfer of T cell receptor transgenic T cells and major histocompatibility complex (MHC) class I tetramers. Soluble antigen immunization induced entry of CD8 cells into the intestinal mucosa and cytotoxic T lymphocyte (CTL) differentiation, whereas CD8 cells in secondary lymphoid tissue proliferated but were not cytolytic. Immunization concurrent with CD40L blockade or in the absence of CD40 demonstrated that accumulation of CD8 T cells in the mucosa was CD40L dependent. Furthermore, activation was mediated through CD40L expressed by the CD8 cells, since inhibition by anti-CD40L monoclonal antibodies occurred after adoptive transfer to CD40L-deficient mice. However, mucosal CD8 T cells in normal and CD40−/− mice were equivalent killers, indicating that CD40L was not required for CTL differentiation. Appearance of virus-specific mucosal, but not splenic, CD8 cells also relied heavily on CD40–CD40L interactions. The mucosal CTL response of transferred CD8 T cells was MHC class II and interleukin 12 independent. The results established a novel pathway of direct CD40L-mediated CD8 T cell activation.
Managing children's cancer pain in Morocco.

PURPOSE To identify issues in managing pain of children with cancer in the two pediatric oncology centers in Morocco. METHODS Focus groups were conducted with pediatric oncology nurses and physicians. FINDINGS Four themes were identified: (a) children's cancer pain is an overwhelming concern to the Moroccan nurses and physicians who participated in this study; (b) training and resources for children's cancer pain management are lacking in Morocco; (c) some impediments to pain relief were verbalized, such as a stoic approach to suffering and limited use of some drugs; and (d) a critical need exists for a comprehensive pain management approach for children with cancer in Morocco. CONCLUSIONS This study elucidated issues in managing children's cancer pain in Morocco and increased knowledge of current practice issues. A program of policy research has been initiated with the aim of establishing guidelines for practice policies for managing children's cancer pain in Morocco.
Five-Brane Thermodynamics from the Matrix Model

A certain sector of the matrix model for M-theory on a plane wave background has recently been shown to produce the transverse five-brane. We consider this theory at finite temperature. We find that, at a critical temperature it has a Gross-Witten phase transition which corresponds to deconfinement of the matrix model gauge theory. We interpret the phase transition as the Hagedorn transition of M-theory and of type II string theory in the five-brane background. We also show that there is no Hagedorn behaviour in the transverse membrane background case.
BOLD Response Selective to Flow-Motion in Very Young Infants

In adults, motion perception is mediated by an extensive network of occipital, parietal, temporal, and insular cortical areas. Little is known about the neural substrate of visual motion in infants, although behavioural studies suggest that motion perception is rudimentary at birth and matures steadily over the first few years. Here, by measuring Blood Oxygenated Level Dependent (BOLD) responses to flow versus random-motion stimuli, we demonstrate that the major cortical areas serving motion processing in adults are operative by 7 wk of age. Resting-state correlations demonstrate adult-like functional connectivity between the motion-selective associative areas, but not between primary cortex and temporo-occipital and posterior-insular cortices. Taken together, the results suggest that the development of motion perception may be limited by slow maturation of the subcortical input and of the cortico-cortical connections. In addition they support the existence of independent input to primary (V1) and temporo-occipital (V5/MT+) cortices very early in life.
Optimal costs of HIV pre-exposure prophylaxis for men who have sex with men

Introduction Men who have sex with men (MSM) are disproportionately affected by HIV due to their increased risk of infection. Oral pre-exposure prophylaxis (PrEP) is a highly effictive HIV-prevention strategy for MSM. Despite evidence of its effectiveness, PrEP uptake in the United States has been slow, in part due to its cost. As jurisdictions and health organizations begin to think about PrEP scale-up, the high cost to society needs to be understood. Methods We modified a previously-described decision-analysis model to estimate the cost per quality-adjusted life-year (QALY) gained, over a 1-year duration of PrEP intervention and lifetime time horizon. Using updated parameter estimates, we calculated: 1) the cost per QALY gained, stratified over 4 strata of PrEP cost (a function of both drug cost and provider costs); and 2) PrEP drug cost per year required to fall at or under 4 cost per QALY gained thresholds. Results When PrEP drug costs were reduced by 60% (with no sexual disinhibition) to 80% (assuming 25% sexual disinhibition), PrEP was cost-effective (at <$100,000 per QALY averted) in all scenarios of base-case or better adherence, as long as the background HIV prevalence was greater than 10%. For PrEP to be cost saving at base-case adherence/efficacy levels and at a background prevalence of 20%, drug cost would need to be reduced to $8,021 per year with no disinhibition, and to $2,548 with disinhibition. Conclusion Results from our analysis suggest that PrEP drug costs need to be reduced in order to be cost-effective across a range of background HIV prevalence. Moreover, our results provide guidance on the pricing of generic emtricitabine/tenofovir disoproxil fumarate, in order to provide those at high risk for HIV an affordable prevention option without financial burden on individuals or jurisdictions scaling-up coverage.
Search for Non-Gaussian Signals in the BOOMERANG Maps: Pixel-Space Analysis

We search the BOOMERANG (Balloon Observations Of Millimetric Extragalactic Radiation ANd Geophysics) maps of the anisotropy of the cosmic microwave background (CMB) for deviations from Gaussianity. In this Letter, we focus on analysis techniques in pixel space and compute skewness, kurtosis, and Minkowski functionals for the BOOMERANG maps and for Gaussian simulations of the CMB sky. We do not find any significant deviation from Gaussianity in the high galactic latitude section of the 150 GHz map. We do find deviations from Gaussianity at lower latitudes and at 410 GHz, and we ascribe them to Galactic dust contamination. Using non-Gaussian simulations of instrumental systematic effects, of foregrounds, and of sample non-Gaussian cosmological models, we set upper limits to the non-Gaussian component of the temperature field in the BOOMERANG maps. For fluctuations distributed as a 1 degree of freedom χ2 mixed to the main Gaussian component, our upper limits are in the few percentile range.
Comparative study of carbon fabric reinforced and glass fabric reinforced thin sandwich panels under impact and static loading

Glass fabric reinforced thin sandwich panel and carbon fabric reinforced thin sandwich panel of thickness close to 2.5 mm were studied to explore an alternative skin material for the outer body of various machines and appliances. The polyester foam Coremat XM of 2 mm thickness was used as core material in the thin sandwich panels. The panels were fabricated by vacuum bagging process and characterized through two plate tests: (i) low-velocity normal impact loading under a drop weight impact test set up and (ii) transverse static loading of a plate. The damage area, indentation depth and permanent depression over damage area, energy absorption capability, load-deflection relation and failure modes were observed under the test. The impact drop test was simulated by LS-DYNA. The properties of glass fabric reinforced thin sandwich panel and carbon fabric reinforced thin sandwich panel were compared with those of 0.8-mm-thick MS sheet, a widely used skin material for the outer body of various machines and appliances.
A New Characterization of Fine Scale Diffusion on the Cell Membrane

We use a large single particle tracking data set to analyze the short time and small spatial scale motion of quantum dots labeling proteins in cell membranes. Our analysis focuses on the jumps which are the changes in the position of the quantum dots between frames in a movie of their motion. Previously we have shown that the directions of the jumps are uniformly distributed and the jump lengths can be characterized by a double power law distribution. Here we show that the jumps over a small number of time steps can be described by scalings of a {\em single} double power law distribution. This provides additional strong evidence that the double power law provides an accurate description of the fine scale motion. This more extensive analysis provides strong evidence that the double power law is a novel stable distribution for the motion. This analysis provides strong evidence that an earlier result that the motion can be modeled as diffusion in a space of fractional dimension roughly 3/2 is correct. The form of the power law distribution quantifies the excess of short jumps in the data and provides an accurate characterization of the fine scale diffusion and, in fact, this distribution gives an accurate description of the jump lengths up to a few hundred nanometers. Our results complement of the usual mean squared displacement analysis used to study diffusion at larger scales where the proteins are more likely to strongly interact with larger membrane structures.
Efficacy of retinol palmitate eye drops for dry eye in rabbits with lacrimal gland resection

Purpose We examined the efficacy of retinol palmitate (VApal) for dry eyes using dry eye model rabbits whose lacrimal glands were resected. Materials and methods After alkaline injury on keratoconjunctival epithelium, VApal eye drops were administered 6 times a day for 7 days. The efficacy of VApal was also compared with that of 0.1% hyaluronic acid eye drops. Results The fluorescein staining and rose bengal scores showed a significant decrease compared with the score in the vehicle group at 7 days (P < 0.05) in the 1000 IU/mL VApal group and at both 3 days (P < 0.05) and 7 days (P < 0.01) in the 1500 IU/mL VApal group. Histological examination revealed recovery of the corneal epithelium, and PAS staining disclosed the recovery of mucin-producing lower palpebral conjunctival goblet cells after 7 days in the 1500 IU/mL VApal group compared with the vehicle group. Results from impression cytology showed a significant increase in density of conjunctival goblet cells compared with that in the vehicle group after 7 days in the 1000 IU/mL VApal group and after 3 and 7 days in the 1500 IU/mL VApal group. There were no significant changes in tear flow in either group. Topical application of VApal at 1500 IU/mL showed greater improvement than 0.1% hyaluronic acid in both fluorescein and rose bengal score and in the density of conjunctival goblet cells. Conclusion It is suggested that VApal is effective for the improvement of keratoconjunctival epithelial damage associated with tear abnormalities, such as dry eyes.