Miracle-dz/UniFAR-FTUs huggingface dataset:
Context Learning in the Rodent Hippocampus

We present a Bayesian statistical theory of context learning in the rodent hippocampus. While context is often defined in an experimental setting in relation to specific background cues or task demands, we advance a single, more general notion of context that suffices for a variety of learning phenomena. Specifically, a context is defined as a statistically stationary distribution of experiences, and context learning is defined as the problem of how to form contexts out of groups of experiences that cluster together in time. The challenge of context learning is solving the model selection problem: How many contexts make up the rodent's world? Solving this problem requires balancing two opposing goals: minimize the variability of the distribution of experiences within a context and minimize the likelihood of transitioning between contexts. The theory provides an understanding of why hippocampal place cell remapping sometimes develops gradually over many days of experience and why even consistent landmark differences may need to be relearned after other environmental changes. The theory provides an explanation for progressive performance improvements in serial reversal learning, based on a clear dissociation between the incremental process of context learning and the relatively abrupt context selection process. The impact of partial reinforcement on reversal learning is also addressed. Finally, the theory explains why alternating sequence learning does not consistently result in unique context-dependent sequence representations in hippocampus.
Immunogenicity and Efficacy of Flagellin-Envelope Fusion Dengue Vaccines in Mice and Monkeys

ABSTRACT The envelope (E) protein of flaviviruses includes three domains, EI, EII, and EIII, and is the major protective antigen. Because EIII is rich in type-specific and subcomplex-specific neutralizing epitopes and is easy to express, it is particularly attractive as a recombinant vaccine antigen. VaxInnate has developed a vaccine platform that genetically links vaccine antigens to bacterial flagellin, a Toll-like receptor 5 ligand. Here we report that tetravalent dengue vaccines (TDVs) consisting of four constructs, each containing two copies of EIII fused to flagellin (R3.2x format), elicited robust and long-lived neutralizing antibodies (geometric mean titers of 200 to 3,000), as measured with a 50% focus reduction neutralization test (FRNT50). In an immunogenicity study, rhesus macaques (n = 2) immunized subcutaneously with 10 μg or 90 μg of TDV three or four times, at 4- to 6-week intervals, developed neutralizing antibodies to four dengue virus (DENV) serotypes (mean post-dose 3 FRNT50 titers of 102 to 601). In an efficacy study, rhesus macaques (n = 4) were immunized intramuscularly with 16 μg or 48 μg of TDV or a placebo control three times, at 1-month intervals. The animals that received 48-μg doses of TDV developed neutralizing antibodies against the four serotypes (geometric mean titers of 49 to 258) and exhibited reduced viremia after DENV-2 challenge, with a group mean viremia duration of 1.25 days and 2 of 4 animals being completely protected, compared to the placebo-treated animals, which all developed viremia, with a mean duration of 4 days. In conclusion, flagellin-EIII fusion vaccines are immunogenic and partially protective in a nonhuman primate model.
Expression of the EGF Family in Gastric Cancer: Downregulation of HER4 and Its Activating Ligand NRG4

Gastric cancer is a major cause of cancer-related deaths in both men and women. The epidermal growth factor receptors are EGFR, HER2, HER3 and HER4. Of the four epidermal growth factor receptors, EGFR and HER2 are well-known oncogenes involved in gastric cancer. Little, however, is known about the role played by HER3 and HER4 in this disease. We obtained paired samples from the tumor and the adjacent normal tissue from the same patient undergoing surgery for gastric cancer. Using RT-qPCR, we quantified the mRNA expression of the four receptors including the HER4 splicing isoforms and all the ligands activating these receptors. Using immunohistochemistry, the protein expression of HER4 was also quantified. We found that HER2 mRNA expression was upregulated in the tumor tissue compared to the matched normal tissue (p = 0.0520). All ligands with affinity for EGFR were upregulated, whereas the expression of EGFR was unchanged. Interestingly, we found the mRNA expression of HER4 (p = 0.0002) and its ligand NRG4 (p = 0.0009) to be downregulated in the tumor tissue compared to the matched normal tissue. HER4 downregulation was demonstrated for all the alternatively spliced isoforms of this receptor. These results support the involvement of EGFR and HER2 in gastric cancer and suggest an interesting association of reduced HER4 expression with development of gastric cancer.
Mating type‐dependent partner sensing as mediated by VEL1 in T richoderma reesei

Sexual development in the filamentous model ascomycete Trichoderma reesei (syn. Hypocrea jecorina) was described only a few years ago. In this study, we show a novel role for VELVET in fungi, which links light response, development and secondary metabolism. Vel1 is required for mating in darkness, normal growth and conidiation. In light, vel1 was dispensable for male fertility but essential for female fertility in both mating types. VEL1 impacted regulation of the pheromone system (hpr1, hpr2, hpp1, ppg1) in a mating type‐dependent manner and depending on the mating partner of a given strain. These partner effects only occurred for hpp1 and hpr2, the pheromone precursor and receptor genes associated with the MAT1‐2 mating type and for the mating type gene mat1‐2‐1. Analysis of secondary metabolite patterns secreted by wild type and mutants under asexual and sexual conditions revealed that even in the wild type, the patterns change upon encounter of a mating partner, with again distinct differences for wild type and vel1 mutants. Hence, T. reesei applies a language of pheromones and secondary metabolites to communicate with mating partners and that this communication is at least in part mediated by VEL1.
Sense of coherence and life satisfaction in people suffering from mental health problems : an intervention study in talk-therapy groups with focus on salutogenesis

Background: The increasing number of people who live in the community for many years with mental health problems (MHP) brings into focus the need for recovery within a coping, health promotion and life satisfaction perspective. Although the theory of salutogenesis provides generic understanding of how coping as a sense of coherence (SOC) may be created, and thus decisively determines the ability to recuperate, this theoretical perspective has not been explored sufficiently within research of people suffering from MHP. Aims: The main aim of the present study was to increase knowledge about therapy and assessment of MHP in a health promotion and life satisfaction perspective. This was done firstly when developing salutogenic therapy principles; secondly, in a randomized controlled trial investigating the effect of these principles on coping (SOC) with MHP; thirdly, by exploring quality of life among people with MHP compared with the general population; and fourthly, by investigating the utility of SOC versus mental symptoms as predictors for life satisfaction development. Method: The main sample consisted of 107 residents in the community who have MHP. In addition, a general population sample (n = 1893) was used as a comparison group for life satisfaction. The following different designs were used: a randomized controlled trial (Paper II), a cross-sectional comparative design (Paper III), and a prospective one-year follow-up design (Paper IV). The MHP sample answered a mailed questionnaire three times during a one-year period. The Sense of Coherence Questionnaire was used as a measure of coping, while life satisfaction was measured by the Quality of Life Scale, and the Symptom Checklist–90 was used for a description of the participants’ mental
Is There an Association Between Empathic Speech and Change Talk in Motivational Interviewing Sessions?

Although empathy is identified as an important component of effective Motivational Interviewing, there is little research that explores clinician in-session empathic expressions and the relationship that these expressions have with other theoretically important behaviors, particularly client change language. This study identified empathic speech at the level of clinician utterances and explored the association of such speech with client change language, finding that the frequency of empathic speech was positively associated with client change talk and client sustain talk. This correlation between empathic speech and change talk was mediated by clinician reflections of client change talk. Similarly, the relationship between empathic speech and sustain talk was mediated by clinician reflections of it. Clinical implications and further directions for research are discussed.
A minimax robust decoding algorithm

We study the decoding problem in an uncertain noise environment. If the receiver knows the noise probability density function (PDF) at each time slot or its a priori probability, the standard Viterbi (1967) algorithm (VA) or the a posteriori probability (APP) algorithm can achieve optimal performance. However, if the actual noise distribution differs from the noise model used to design the receiver, there can be significant performance degradation due to the model mismatch. The minimax concept is used to minimize the worst possible error performance over a family of possible channel noise PDFs. We show that the optimal robust scheme is difficult to derive; therefore, alternative, practically feasible, robust decoding schemes are presented and implemented on a VA decoder and two-way APP decoder. The performance analysis and numerical results show our robust decoders have a performance advantage over standard decoders in uncertain noise channels, with no or little computational overhead. Our robust decoding approach can also explain why for turbo decoding overestimating the noise variance gives better results than underestimating it.
The positive educational practices framework: A tool for facilitating the work of educational psychologists in promoting pupil wellbeing

This paper outlines the Positive Educational Practices (PEPs) Framework, an organising tool for facilitating the work of educational psychologists in promoting pupil wellbeing and supporting pupils to achieve learning outcomes and engage in pro-social behaviour. The PEPs Framework is an example of applied positive psychology, in itself a movement which has shifted the primary focus of psychologists from deficits, problems and treatment to a preventative focus on positive experiences, strengths and the intentional promotion of wellbeing and resilience. PEPs is a wide-ranging prevention framework based on five foundations of wellbeing drawn not only from research in positive psychology but also from research in other contemporary psychological and educational movements that are consistent with positive psychology. The five foundations: social and emotional competency, positive emotions, positive relationships, engagement through strengths and a sense of meaning and purpose are outlined along with examples of practical suggestions that can contribute to their achievement.
Firm, strategic group, and industry influences on performance

A long-standing debate has focused on the extent to which different levels of analysis shape firm performance. The strategic group level has been largely excluded from this inquiry, despite evidence that group membership matters. In this study, we use hierarchical linear modeling to simultaneously estimate firm-, strategic group-, and industry-level influences on short-term and long-term measures of performance. We assess the three levels' explanatory power using a sample of 1,165 firms in 12 industries with data from a 7-year period. To enhance comparability to previous research, we also estimate the effects using the variance components and ANOVA methods relied on in past studies. To assess the robustness of strategic group effects, we examine both deductively and inductively defined groups. We found that all three levels are significantly associated with performance. The firm effect is the strongest, while the strategic group effect rivals and for some measures outweighs the industry effect. We also found that the levels have varying effects in relation to different performance measures, suggesting more complex relationships than depicted in previous studies. Copyright © 2007 John Wiley & Sons, Ltd.
A SINGULARITY-FREE COSMOLOGICAL MODEL WITH A CONFORMALLY COUPLED SCALAR FIELD

We explore the possibility of describing our universe with a singularity--free, closed, spatially homogeneous and isotropic cosmological model, using only general relativity and a suitable equation of state which produces an inflationary era. A phase transition to a radiation--dominated era occurs as a consequence of boundary conditions expressing the assumption that the temperature cannot exceed the Planck value. We find that over a broad range of initial conditions, the predicted value of the Hubble parameter is approximately $47$ km$\cdot$~s$^{-1}\cdot$~Mpc$^{-1}$. Inflation is driven by a scalar field, which must be conformally coupled to the curvature if the Einstein equivalence principle has to be satisfied. The form of the scalar field potential is derived, instead of being assumed a priori.
Systems Biology Studies of Adult Paragonimus Lung Flukes Facilitate the Identification of Immunodominant Parasite Antigens

Background Paragonimiasis is a food-borne trematode infection acquired by eating raw or undercooked crustaceans. It is a major public health problem in the far East, but it also occurs in South Asia, Africa, and in the Americas. Paragonimus worms cause chronic lung disease with cough, fever and hemoptysis that can be confused with tuberculosis or other non-parasitic diseases. Treatment is straightforward, but diagnosis is often delayed due to a lack of reliable parasitological or serodiagnostic tests. Hence, the purpose of this study was to use a systems biology approach to identify key parasite proteins that may be useful for development of improved diagnostic tests. Methodology/Principal Findings The transcriptome of adult Paragonimus kellicotti was sequenced with Illumina technology. Raw reads were pre-processed and assembled into 78,674 unique transcripts derived from 54,622 genetic loci, and 77,123 unique protein translations were predicted. A total of 2,555 predicted proteins (from 1,863 genetic loci) were verified by mass spectrometric analysis of total worm homogenate, including 63 proteins lacking homology to previously characterized sequences. Parasite proteins encoded by 321 transcripts (227 genetic loci) were reactive with antibodies from infected patients, as demonstrated by immunoaffinity purification and high-resolution liquid chromatography-mass spectrometry. Serodiagnostic candidates were prioritized based on several criteria, especially low conservation with proteins in other trematodes. Cysteine proteases, MFP6 proteins and myoglobins were abundant among the immunoreactive proteins, and these warrant further study as diagnostic candidates. Conclusions The transcriptome, proteome and immunolome of adult P. kellicotti represent a major advance in the study of Paragonimus species. These data provide a powerful foundation for translational research to develop improved diagnostic tests. Similar integrated approaches may be useful for identifying novel targets for drugs and vaccines in the future.
Knowledge and Management of Sports Concussions among Coaches and Certified Athletic Trainers in Alabama

Objectives To identify modifiable barriers in resources, knowledge, and management that may improve the care of young athletes with concussions in the state of Alabama. Methods An electronic survey was distributed to 2668 middle and high school coaches of contact sports in Alabama, and a paper survey was completed by 79 certified athletic trainers (ATCs) in 2010. Questions focused on their resource availability, knowledge of concussions based on the 2008 Consensus Statement on Concussion in Sport: the 3rd International Conference on Concussion in Sport (commonly known as the Zurich consensus statement), and management of concussions. Results A total of 402 (16% response rate) coaches and 55 ATCs (70% response rate) responded to the survey. This study highlights that ATC coverage often is limited to the high school level, football, and competitions. Both coaches and ATCs primarily use physicians to make return-to-play decisions, although coaches (43.7%) usually refer to primary care physicians, whereas ATCs (43.6%) refer to orthopedic or sports medicine physicians. The study also revealed that coaches and ATCs desire education and could expand concussion awareness by providing education to parents and athletes. No overall difference was seen in the knowledge and management of concussions between coaches and ATCs; however, ATCs were more likely to identify symptoms that are positive for concussions (P = 0.04). Both groups had difficulty recognizing subtle symptoms such as trouble sleeping, personality changes, and dizziness; they also were unaware that strenuous mental activities could delay concussion recovery, although ATCs scored significantly better than coaches (P < 0.001). Neither coaches nor ATCs consistently use standardized measures such as the Sports Concussion Assessment Tool 2 (7.5% vs 56.4%) or neuropsychological testing (5.3% vs 14.5%). Conclusions This study describes coaches’ and ATCs’ varying knowledge and management techniques and highlights areas in which targeted interventions and outreach could be useful. These areas include increased ATC availability, coach/ATC concussion education, improved parent/athlete education, increased “return to think” awareness, and more consistent use of Sports Concussion Assessment Tool 2.
Spectral analysis of the Forel-Ule ocean colour comparator scale

Francois Alphonse Forel (1890) and Willi Ule (1892) composed a colour comparator scale, with tints varying from indigo-blue to coca-cola brown, to quantify the colour of natural waters, like seas, lakes and rivers. For each measurement, the observer compares the colour of the water above a submersed white disc (Secchi disc) with the hand-held scale of pre-defined colours. The scale can be well reproduced from a simple recipe for twenty-one coloured chemical solutions and because the ease of its use, the Forel-Ule (FU) scale has been applied globally and intensively by oceanographers and limnologists from the year 1890. Indeed, the archived FU data belong to the oldest oceanographic data sets and do contain information on the changes in geobiophysical properties of natural waters during the last century. In this article we describe the optical properties of the FU-scale and its ability to cover the colours of natural waters, as observed by the human eye. The recipe of the scale and its reproduction is described. The spectral transmission of the tubes, with belonging chromaticity coordinates, is presented. The FU scale, in all its simplicity, is found to be an adequate ocean colour comparator scale. The scale is well characterized, is stable and observations are reproducible. This supports the idea that the large historic data base of FU measurements is coherent and well calibrated. Moreover, the scale can be coupled to contemporary multi-spectral observations with hand-held and satellite-based spectrometers.
Work and Family: a complex interplay. An Italian application of the DISC Model on health care workers

The present thesis investigates the issue of work-family conflict and facilitation in a sanitarian contest, using the DISC Model (De Jonge and Dormann, 2003, 2006). The general aim has been declined in two empirical studies reported in this dissertation chapters. Chapter 1 reporting the psychometric properties of the Demand-Induced Strain Compensation Questionnaire. Although the empirical evidence on the DISC Model has received a fair amount of attention in literature both for the theoretical principles and for the instrument developed to display them (DISQ; De Jonge, Dormann, Van Vegchel, Von Nordheim, Dollard, Cotton and Van den Tooren, 2007) there are no studies based solely on psychometric investigation of the instrument. In addition, no previous studies have ever used the DISC as a model or measurement instrument in an Italian context. Thus the first chapter of the present dissertation was based on psychometric investigation of the DISQ. Chapter 2 reporting a longitudinal study contribution. The purpose was to examine, using the DISC model, the relationship between emotional job characteristics, work-family interface and emotional exhaustion among a health care population. We started testing the Triple Match Principle of the DISC Model using solely the emotional dimension of the strain-stress process (i.e. emotional demands, emotional resources and emotional exhaustion). Then we investigated the mediator role played by w-f conflict and w-f facilitation in relation to emotional job characteristics and emotional exhaustion. Finally we compared the mediator model across workers involved in chronic illness home demands and workers who are not involved. Finally, a general conclusion, integrated and discussed the main findings of the studies reported in this dissertation.
A rational route to randomness

Complex dynamics in economics arise from nonlinear systems that do not converge to a fixed point, a limit cycle, or explode or implode exponentially due to endogenous factors. They arise from cybernetics, catastrophe theory, chaos theory, or the varieties of modern complexity theory, including models with heterogeneous, interacting agents. This major three-volume collection presents the most important papers in the area of complexity in economics.
Increasing Incidence of Canine Leptospirosis in Switzerland

A marked increase in canine leptospirosis was observed in Switzerland over 10 years with a peak incidence of 28.1 diagnosed cases/100,000 dogs/year in the most affected canton. With 95% affected dogs living at altitudes <800 m, the disease presented a seasonal pattern associated with temperature (r2 0.73) and rainfall (r2 0.39), >90% cases being diagnosed between May and October. The increasing yearly incidence however was only weakly correlated with climatic data including number of summer (r2 0.25) or rainy days (r2 0.38). Serovars Australis and Bratislava showed the highest seropositivity rates with 70.5% and 69.1%, respectively. Main clinical manifestations included renal (99.6%), pulmonary (76.7%), hepatic (26.0%), and hemorrhagic syndromes (18.2%), leading to a high mortality rate (43.3%). Similar to the human disease, liver involvement had the strongest association with negative outcome (OR 16.3). Based on these data, canine leptospirosis presents similar features and severity as the human infection for which it therefore can be considered a model. Its re-emergence in a temperate country with very high incidence rates in canines should thus be viewed as a warning and emphasize the need for increased awareness in other species.
Public Spaces, Private Lives: Democracy Beyond 9/11

Chapter 1 Introduction Chapter 2 Cultural Studies and the Culture of Politics Chapter 3 Youth, Domestic Militarization, and the Politics of Zero Tolerance Chapter 4 Private Satisfactions and Public Disorders Chapter 5 Pedagogy of the Depressed Chapter 6 "Something's Missing" Chapter 7 Afterword