Miracle-dz/UniFAR-FTUs huggingface dataset:
Perinatal Outcomes in Singletons Following In Vitro Fertilization: A Meta-Analysis

OBJECTIVE: To estimate whether singleton pregnancies following in vitro fertilization (IVF) are at higher risk of perinatal mortality, preterm delivery, small for gestational age, and low or very low birth weight compared with spontaneous conceptions in studies that adjusted for age and parity. DATA SOURCES: We searched MEDLINE, BIOSIS, Doctoral Dissertations On-Line, bibliographies, and conference proceedings for studies from 1978–2002 using the terms “in vitro fertilization,” “female infertility therapy,” and “reproductive techniques” combined with “fetal death,” “mortality,” “fetal growth restriction,” “small for gestational age,” “birth weight,” “premature labor,” “preterm delivery,” “infant,” “obstetric,” “perinatal,” and “neonatal. ” METHODS OF STUDY SELECTION: Inclusion criteria were singleton pregnancies following IVF compared with spontaneous conceptions, control for maternal age and parity; 1 of the above outcomes; and risk ratios or data to determine them. Study selection and data abstraction were performed in duplicate after removing identifying information. TABULATION, INTEGRATION, AND RESULTS: Fifteen studies comprising 12,283 IVF and 1.9 million spontaneously conceived singletons were identified. Random-effects meta-analysis was performed. Compared with spontaneous conceptions, IVF singleton pregnancies were associated with significantly higher odds of each of the perinatal outcomes examined: perinatal mortality (odds ratio [OR] 2.2; 95% confidence interval [CI] 1.6, 3.0), preterm delivery (OR 2.0; 95% CI 1.7, 2.2), low birth weight (OR 1.8; 95% CI 1.4, 2.2), very low birth weight (OR 2.7; 95% CI 2.3, 3.1), and small for gestational age (OR 1.6; 95% CI 1.3, 2.0). Statistical heterogeneity was noted only for preterm delivery and low birth weight. Sensitivity analyses revealed no significant changes in results. Early preterm delivery, spontaneous preterm delivery, placenta previa, gestational diabetes, preeclampsia, and neonatal intensive care admission were also significantly more prevalent in the IVF group. CONCLUSION: In vitro fertilization patients should be advised of the increased risk for adverse perinatal outcomes. Obstetricians should not only manage these pregnancies as high risk but also avoid iatrogenic harm caused by elective preterm labor induction or cesarean.
Beneficial effect of prolonged heme oxygenase 1 activation in a rat model of chronic heart failure

SUMMARY We and others have previously demonstrated that heme oxygenase 1 (HO-1) induction by acute hemin administration exerts cardioprotective effects. Here, we developed a rat model of heart failure to investigate whether a long-term induction of HO-1 by chronic hemin administration exerted protective effects. Sprague Dawley rats that underwent permanent ligation of the left coronary artery were closely monitored for survival rate analysis and sacrificed on day 28 post-operation. Administration of hemin (4 mg/kg body weight) every other day for 4 weeks induced a massive increase in HO-1 expression and activity, as shown by the increased levels of the two main metabolic products of heme degradation, bilirubin and carbon monoxide (CO). These effects were associated with significant improvement in survival and reduced the extension of myocardial damage. The ischemic hearts of the hemin-treated animals displayed reduced oxidative stress and apoptosis in comparison with the non-treated rats, as shown by the decreased levels of lipid peroxidation, free-radical-induced DNA damage, caspase-3 activity and Bax expression. Besides, chronic HO-1 activation suppressed the elevated levels of myeloperoxidase (MPO) activity, interleukin 1β (IL-1β) production and tumor necrosis factor-α (TNFα) production that were evoked by the ischemic injury, and increased the plasma level of the anti-inflammatory cytokine IL-10. Interestingly, HO-1 inhibitor zinc protoporphyrin IX (ZnPP-IX; 1 mg/kg) lowered bilirubin and CO concentrations to control values, thus abolishing all the cardioprotective effects of hemin. In conclusion, the results demonstrate that chronic HO-1 activation by prolonged administration of hemin improves survival and exerts protective effects in a rat model of myocardial ischemia by exerting a potent antioxidant activity and disrupting multiple levels of the apoptotic and inflammatory cascade.
Liana infestation impacts tree growth in a lowland tropical moist forest

Abstract. Ecosystem-level estimates of the effect of lianas on tree growth in mature tropical forests are needed to evaluate the functional impact of lianas and their potential to affect the ability of tropical forests to sequester carbon, but these are currently lacking. Using data collected on tree growth rates, local growing conditions and liana competition in five permanent sampling plots in Amazonian Peru, we present the first ecosystem-level estimates of the effect of lianas on above-ground productivity of trees. By first constructing a multi-level linear mixed effect model to predict individual-tree diameter growth model using individual-tree growth conditions, we were able to then estimate stand-level above-ground biomass (AGB) increment in the absence of lianas. We show that lianas, mainly by competing above-ground with trees, reduce tree annual above-ground stand-level biomass increment by ~10%, equivalent to 0.51 Mg dry weight ha−1 yr−1 or 0.25 Mg C ha−1 yr−1. AGB increment of lianas themselves was estimated to be 0.15 Mg dry weight ha−1 yr−1 or 0.07 Mg C ha−1 yr−1, thus only compensating ~29% of the liana-induced reduction in ecosystem AGB increment. Increasing liana pressure on tropical forests will therefore not only tend to reduce their carbon storage capacity, by indirectly promoting tree species with low-density wood, but also their rate of carbon uptake, with potential consequences for the rate of increase in atmospheric carbon dioxide.
Barycentric Graph Clustering

Clustering is an essential aid to human understanding. In its application to graphs, clustering allows a large graph to be partitioned into pieces that can be studied independently or collapsed to give a coarse picture. More importantly, it can be used to identify coherent subgraphs that bear particular attention. As the size of graphs under examination has continued to increase, it has become increasingly important to devise graph algorithms that scale well. This need is felt particularly for graph clustering and for extracting subgraphs of interest, precisely because human comprehension of large graphs is impractical. This paper presents a family of stochastic methods for clustering graphs into coherent subgraphs. These methods scale linearly with the graph size and do not require a priori specification of the number or size of clusters. After a physical motivation, an exposition of the methods is presented, followed by experimental results on some sample graphs.
Health Literacy and Older Adults

Objective: The objective of this review was to assess published literature relating to health literacy and older adults. Method: The current review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta Analyses. Results: Eight articles met inclusion criteria. All studies were conducted in urban settings in the United States. Study sample size ranged from 33 to 3,000 participants. Two studies evaluated health-related outcomes and reported significant associations between low health literacy and poorer health outcomes. Two other studies investigated the impact of health literacy on medication management, reporting mixed findings. Discussion: The findings of this review highlight the importance of working to improve health care strategies for older adults with low health literacy and highlight the need for a standardized and validated clinical health literacy screening tool for older adults.
"With-Me-Ness": A Gaze-Measure for Students' Attention in MOOCs

We propose a gaze-based indicator of students’ attention in a MOOC video lecture. We report the results from an eye-tracking study during a MOOC lecture. We define the gaze- based indicator of students’ attention as “with-me-ness”. This answers a question from teachers’ perspective “how much are the students with me? ” With-me-ness is defined at two levels: perceptual, following teacher’s deictic acts- and conceptual – following teacher discourse. We conducted an experiment with 40 participants and observed a significant and positive correlation between the two levels of with-me-ness and the posttest scores.
Learning from School Reform.

This paper asserts that creating successful school reform can be difficult. The first part discusses the concept of school culture to explain challenges to school reform, examining why existing school culture is necessary for a smoothly functioning and stable school but an obstacle to educational change and noting that attempts to transform school culture through external means usually fail. It introduces the alternative concept of internal transformation of culture, which empowers school participants to change their practices, expectations, and attitudes via a change process that sets new goals and provides tools to help reach them. The second part introduces the Accelerated Schools Project (ASP) in the United States and Hong Kong, which transforms traditional schools that rely on rote learning into schools that utilize approaches typically used with gifted and talented students. The paper examines whether a reform model developed in one country can successfully transform schools in another, culturally different, country. It introduces facets of the ASP process, linking them to their role in internal cultural transformation. The final section addresses what has been learned in the 50 Hong Kong schools and describes a strategy for ascertaining the conditions under which the ASP approach has shown success, noting how those conditions might be replicated. (Contains 16 references.) (SM) Reproductions supplied by EDRS are the best that can be made from the original document.
Intercellular Communication by Exchange of Cytoplasmic Material via Tunneling Nano-Tube Like Structures in Primary Human Renal Epithelial Cells

Transfer of cellular material via tunneling nanotubes (TNT) was recently discovered as a novel mechanism for intercellular communication. The role of intercellular exchange in communication of renal epithelium is not known. Here we report extensive spontaneous intercellular exchange of cargo vesicles and organelles between primary human proximal tubular epithelial cells (RPTEC). Cells were labeled with two different quantum dot nanocrystals (Qtracker 605 or 525) and intercellular exchange was quantified by high-throughput fluorescence imaging and FACS analysis. In co-culture, a substantial fraction of cells (67.5%) contained both dyes indicating high levels of spontaneous intercellular exchange in RPTEC. The double positive cells could be divided into three categories based on the preponderance of 605 Qtracker (46.30%), 525 Qtracker (48.3%) and approximately equal content of both Qtrackers (4.57%). The transfer of mitochondria between RPTECs was also detected using an organelle specific dye. Inhibition of TNT genesis by actin polymerization inhibitor (Latrunculin B) markedly reduced intercellular exchange (>60%) suggesting that intercellular exchange in RPTEC was in part mediated via TNT-like structures. In contrast, induction of cellular stress by Zeocin treatment increased tube-genesis in RPTEC. Our data indicates an unexpected dynamic of intercellular communication between RPTEC by exchange of cytosolic material, which may play an important role in renal physiology.
Boom-bust cycles and financial liberalization

The volatility that has hit many middle-income countries (MICs) after liberalizing their financial markets has prompted critics to call for new policies to stabilize these boom-bust cycles. But, as Aaron Tornell and Frank Westermann point out in this book, over the last two decades most of the developing countries that have experienced lending booms and busts have also exhibited the fastest growth among MICs. Countries with more stable credit growth, by contrast, have exhibited, on average, lower growth rates. Factors that contribute to financial fragility thus appear, paradoxically, to be a source of long-run growth as well. Tornell and Westermann analyze boom-bust cycles in the developing world and discuss how these cycles are generated by credit market imperfections. They explain why the financial liberalization that allows countries to overcome imperfections impeding rapid growth also generates the financial fragility that leads to greater volatility and occasional crises. The conceptual framework they present illustrates this linkage and allows Tornell and Westermann to address normative questions regarding liberalization policies. The authors also characterize key macroeconomic regularities observed across MICs, showing that credit markets play a key role not only in boom-bust episodes but in the strong "credit channel" observed during tranquil times. A theoretical framework is then presented that explains how credit market imperfections can account for these empirical patterns. Finally, Tornell and Westermann provide microeconomic evidence on the credit market imperfections that drive the results of the theoretical framework, finding that asymmetries between tradables and nontradables are key to understanding the patterns in MIC data.
Thymidylate synthase binds to c-myc RNA in human colon cancer cells and in vitro

Using an immunoprecipitation-reverse transcription-PCR technique, we characterized a thymidylate synthase (TS) ribonucleoprotein complex in cultured human colon cancer cells that consists of TS protein and the mRNA of the nuclear oncogene c-myc. TS protein is complexed in intact cells with the C-terminal coding region of c-myc mRNA that includes nucleotide positions 1625 to 1790. RNA electrophoretic gel mobility shift assays confirm a specific interaction between TS protein and c-myc mRNA and provide additional evidence that the C-terminal coding region represents an important cis-acting regulatory element. Further evidence demonstrates that the in vitro translational efficiency of c-myc mRNA is inhibited as a result of its direct interaction with TS protein. In addition, the presence of exogenous c-myc mRNA specifically relieves the inhibitory effects of TS protein on TS mRNA translation.
Dividend Reductions and Interim Effect: UK Evidence

Short-term price reactions to dividend reductions of UK firms that did not reduce their dividends in the previous three-year period are studied. Price reactions to interim and final dividend reductions are found to be significantly negative and stronger for interim dividend reductions. Though market reacted negatively around final dividend reduction announcements it bounced back to its prior level within one month of announcements. The magnitude of price reactions to dividend reductions is found to be statistically related to the size of the dividend reduction, the post-announcement effect from day 2 to day 20, the gearing ratio and dummy variable interim versus final dividend reduction. Interim dividend reductions were found to have incremental information about future annual earnings changes. No incremental information content was found for the final dividend reductions; however, they have information content when included as the only independent variable.
INFLUENCING STUDENTS TO JOIN THEIR AITP STUDENT CHAPTER

The Association of Information Technology Professionals (AITP) is a professional organization that offers students, especially those majoring in Computer Information Systems (CIS) and related majors, a number of opportunities and benefits. We have discovered that a majority of CIS majors at our university, as well as other schools, have not joined their local AITP student chapter. To better understand why some students have not joined AITP, we first conducted interviews with CIS majors, both AITP members and non-AITP members, to elicit their perceptions and opinions about AITP. Based upon the findings from the interviews, we then surveyed 105 CIS students at our institution. We tested for significant differences between AITP members and non-AITP members. We discovered that some students have misperceptions about AITP. We also found that several factors, such as lack of time and money, may deter students from joining AITP. Some students have strong feelings, both positive and negative, about AITP. We used the Theory of Planned Behavior, along with Cognition and Affect constructs, to determine what factors significantly influence students’ intentions to join or remain an AITP student member. As expected, Attitude and Perceived Behavioral Control significantly influence Intention. We also discovered that both Affect and Cognition are important predictors of Attitude. However, we were surprised to find that Subjective Norm does not significantly influence students’ intentions. The model shows an impressive amount of variance explained for Behavioral Intention (R = .743). Our findings provide us evidence of which cognitive, affective, attitudinal, and control beliefs to target in order to better influence students to join their AITP student chapter.
Identification of miRs-143 and -145 that Is Associated with Bone Metastasis of Prostate Cancer and Involved in the Regulation of EMT

The principal problem arising from prostate cancer (PCa) is its propensity to metastasize to bone. MicroRNAs (miRNAs) play a crucial role in many tumor metastases. The importance of miRNAs in bone metastasis of PCa has not been elucidated to date. We investigated whether the expression of certain miRNAs was associated with bone metastasis of PCa. We examined the miRNA expression profiles of 6 primary and 7 bone metastatic PCa samples by miRNA microarray analysis. The expression of 5 miRNAs significantly decreased in bone metastasis compared with primary PCa, including miRs-508-5p, -145, -143, -33a and -100. We further examined other samples of 16 primary PCa and 13 bone metastases using real-time PCR analysis. The expressions of miRs-143 and -145 were verified to down-regulate significantly in metastasis samples. By investigating relationship of the levels of miRs-143 and -145 with clinicopathological features of PCa patients, we found down-regulations of miRs-143 and -145 were negatively correlated to bone metastasis, the Gleason score and level of free PSA in primary PCa. Over-expression miR-143 and -145 by retrovirus transfection reduced the ability of migration and invasion in vitro, and tumor development and bone invasion in vivo of PC-3 cells, a human PCa cell line originated from a bone metastatic PCa specimen. Their upregulation also increased E-cadherin expression and reduced fibronectin expression of PC-3 cells which revealed a less invasive morphologic phenotype. These findings indicate that miRs-143 and -145 are associated with bone metastasis of PCa and suggest that they may play important roles in the bone metastasis and be involved in the regulation of EMT Both of them may also be clinically used as novel biomarkers in discriminating different stages of human PCa and predicting bone metastasis.
State dependence and labour market transitions in the European Union

Using conditional dynamic multinomial logit models that allow to disentangle between state dependence and unobserved heterogeneity, this article proposes an empirical analysis of labour market mobility in the European Union based on EU-SILC data. It shows that the role of true state dependence varies a lot across social groups (according to age, sex and education) and across countries. In particular, state dependence can be related for the different social groups and country groups studied to various structural explanations in terms of institutional arrangements (education and retirement policies, leave policies, childcare policies, labour market policies…) and/or to employers' behaviour.
Histopathology of Incidental Findings in Beagles Used in Toxicity Studies

The purpose of our publication is to widely communicate the pictures of spontaneous findings occurring in beagles. Spontaneous arteritis occurs commonly in beagles. Frequent sites of arteritis are the heart, spleen, pancreas, epididymis and spinal cord. Morphological similarities between spontaneous and drug-induced arterial lesions may cause confusion when evaluating vascular toxicity of chemicals such as vasodilating agents. Focal and minimal inflammatory lesions are occasionally seen in the lung and may be associated with aspiration of food particles or of unknown causes. A cystic change with copious mucin production occurs occasionally in the mucosal epithelium of the gall bladder. Nesidioblastosis is seen rarely in the pancreas of beagles. C-cell complex and lymphocytic thyroiditis are common thyroid lesions. Spontaneous focal hypospermatogenesis and lobular Sertoli-cell-only seminiferous tubules occurring frequently in beagles must be distinguished from drug-induced damage of the seminiferous tubules in toxicity studies. The morphological differences of the female genital system in each cycle need to be understood; therefore, we present the normal features of the cyclic changes of the female genital organs. Further, we provide more information on spontaneous findings in beagles for exact diagnoses in toxicity studies.
Overlapping Networks Engaged during Spoken Language Production and Its Cognitive Control

Spoken language production is a complex brain function that relies on large-scale networks. These include domain-specific networks that mediate language-specific processes, as well as domain-general networks mediating top-down and bottom-up attentional control. Language control is thought to involve a left-lateralized fronto-temporal-parietal (FTP) system. However, these regions do not always activate for language tasks and similar regions have been implicated in nonlinguistic cognitive processes. These inconsistent findings suggest that either the left FTP is involved in multidomain cognitive control or that there are multiple spatially overlapping FTP systems. We present evidence from an fMRI study using multivariate analysis to identify spatiotemporal networks involved in spoken language production in humans. We compared spoken language production (Speech) with multiple baselines, counting (Count), nonverbal decision (Decision), and “rest,” to pull apart the multiple partially overlapping networks that are involved in speech production. A left-lateralized FTP network was activated during Speech and deactivated during Count and nonverbal Decision trials, implicating it in cognitive control specific to sentential spoken language production. A mirror right-lateralized FTP network was activated in the Count and Decision trials, but not Speech. Importantly, a second overlapping left FTP network showed relative deactivation in Speech. These three networks, with distinct time courses, overlapped in the left parietal lobe. Contrary to the standard model of the left FTP as being dominant for speech, we revealed a more complex pattern within the left FTP, including at least two left FTP networks with competing functional roles, only one of which was activated in speech production.
Adaptive ensemble size reduction and inflation

An important question in ensemble based data assimilation scheme is how many ensembles do we require to correctly capture the important features in either our atmospheric or oceanic models given a set of observations. In this paper we present a method to evaluate how many ensembles we require. This method is based on the ensembles representing the modes of the system that contain the directions of maximum variability. We present the theory behind this method as well as an example with a global shallow water equations model on the sphere in conjunction with a ensemble filter under development at Florida State University and the Cooperative Institute for Research in the Atmosphere at Colorado State University.