Miracle-dz/UniFAR-FTUs huggingface dataset:
Enriched acoustic environment rescales auditory sensitivity

Loudness perception may be controlled by a central gain, possibly dependent on the mean level of the acoustic environment. Owing to hearing loss, for instance, a decrease in sensory inputs could increase this central gain and cause an auditory hypersensitivity or hyperacusis. According to this model, individuals with hyperacusis, provided with an enriched acoustic environment specifically designed to compensate for the decrease in sensory inputs, should show an improvement in their hyperacusis. This study showed that such an enriched acoustic environment indeed decreased auditory hypersensitivity: stimuli initially considered as being too loud became comfortable after a few weeks of acoustic stimulation. Therefore, this original approach could provide a solution to the problem of hyperacusis.
Prospective associations of family conflict with alcohol expectancies in the adolescent brain cognitive development study: effects of race and ethnicity

Introduction Alcohol expectancies predict subsequent alcohol use and related problems among adolescents, although predictors of alcohol expectancies remain unclear. This study examined the longitudinal association between family conflict, a sociocultural factor strongly implicated in adolescent alcohol use, and positive and negative alcohol expectancies of adolescents of diverse racial/ethnic backgrounds. Methods Data were from the Adolescent Brain Cognitive Development Study 4.0 release, a multisite longitudinal study (N = 6,231, baseline age 9–10). Linear mixed-effects regression, with interactions between race/ethnicity and family conflict, tested the association between family conflict and alcohol expectancies, for each racial/ethnicity (e.g., Black vs. non-Black; White vs. non-White). Results Interactions of family conflict with race/ethnicity in predicting negative and positive alcohol expectancies were statistically significant for models testing Black and White adolescents, but not for Asian, Hispanic, and Other. Family conflict at baseline predicted lower negative alcohol expectancy for Black adolescents (B = −.166, p = 0.033) and positive alcohol expectancy for White adolescents (B = 0.71, p = 0.023) at the year 3 follow-up. All models controlled for sex, age, family socioeconomic status, alcohol expectancies at year 1, and family conflict at year 3. Conclusion The results indicate that family conflict is a potential risk factor for problematic alcohol expectancies for Black and White adolescents. Although we did not directly compare Black and White adolescents, our findings indicate that family conflict may operate differently for Black and White adolescents. Prevention and intervention efforts targeting family conflict may be relevant for different aspects of alcohol expectancies in Black and White families.
An Estimate of the Global Burden of Anthropogenic Ozone and Fine Particulate Matter on Premature Human Mortality Using Atmospheric Modeling

Background Ground-level concentrations of ozone (O3) and fine particulate matter [≤ 2.5 μm in aerodynamic diameter (PM2.5)] have increased since preindustrial times in urban and rural regions and are associated with cardiovascular and respiratory mortality. Objectives We estimated the global burden of mortality due to O3 and PM2.5 from anthropogenic emissions using global atmospheric chemical transport model simulations of preindustrial and present-day (2000) concentrations to derive exposure estimates. Methods Attributable mortalities were estimated using health impact functions based on long-term relative risk estimates for O3 and PM2.5 from the epidemiology literature. Using simulated concentrations rather than previous methods based on measurements allows the inclusion of rural areas where measurements are often unavailable and avoids making assumptions for background air pollution. Results Anthropogenic O3 was associated with an estimated 0.7 ± 0.3 million respiratory mortalities (6.3 ± 3.0 million years of life lost) annually. Anthropogenic PM2.5 was associated with 3.5 ± 0.9 million cardiopulmonary and 220,000 ± 80,000 lung cancer mortalities (30 ± 7.6 million years of life lost) annually. Mortality estimates were reduced approximately 30% when we assumed low-concentration thresholds of 33.3 ppb for O3 and 5.8 μg/m3 for PM2.5. These estimates were sensitive to concentration thresholds and concentration–mortality relationships, often by > 50%. Conclusions Anthropogenic O3 and PM2.5 contribute substantially to global premature mortality. PM2.5 mortality estimates are about 50% higher than previous measurement-based estimates based on common assumptions, mainly because of methodologic differences. Specifically, we included rural populations, suggesting higher estimates; however, the coarse resolution of the global atmospheric model may underestimate urban PM2.5 exposures.
Particulate Matter and Respiratory Symptoms among Adults Living in Windhoek, Namibia: A Cross Sectional Descriptive Study

This study aimed to estimate the prevalence of respiratory symptoms and to assess respiratory health risks associated with Particulate Matter (PM) exposure among the residents of Windhoek, Namibia. Objectives: To measure particulate pollution concentration in Windhoek through monitoring of particulate matter concentration and to identify any associations between particulate pollution, individual location, and respiratory health among the Windhoek resident’s. Methods: an adapted standardized self-administered questionnaire was used to collect respiratory health related data as well as previous exposure, while PM monitoring was done using the ASTM (American Standard Test Method) D1739 reference method. Results: A high prevalence was observed for cough (43%), breathlessness (25%), and asthma (11.2%). PM was found to be a significant risk factor for episodes of coughing and phlegm, while high PM exposure category had an increased odds ratio (OR) for episodes of phlegm and cough (OR: 2.5, 95% CI (95% confidence intervals): 0.8–8.0). No association was observed between location and respiratory health outcomes. Conclusions: The study found high levels of PM concentration across all Windhoek suburbs which were above the German, American, and Environmental Protection Agency (EPA). Enactment of legislation relating to the control and monitoring of PM related emissions at the point of generation is required at both a country and city level.
Analysis of 51 patients with horseshoe kidney.

HORSESHOE kidney is considered to be one of the more common congenital urologic anomalies, probably occurring in about 0.25 per cent of the general population.1 It is estimated that over 1000 cases are recorded in the literature, either included in various series or as single case reports.2 It has been stated that the existence of horseshoe kidney strongly predisposes to serious renal disease,3 and the vast majority of articles in the literature suggest that the condition is not only prevalent but also of serious consequence.4 The literature deals mainly with the surgery of the horseshoe kidney and with the various .
Genetic Diversity and Identification of Chinese-Grown Pecan Using ISSR and SSR Markers

Pecan is an important horticultural nut crop originally from North America and now widely cultivated in China for its high ecological, ornamental and economic value. Currently, there are over one hundred cultivars grown in China, including introduced American cultivars and Chinese seedling breeding cultivars. Molecular markers were used to assess the genetic diversity of these cultivars and to identify the pedigrees of fine pecan plants with good characteristics and no cultivar-related data. A total of 77 samples grown in China were studied, including 14 introduced cultivars, 12 domestic seedling breeding cultivars, and 49 fine pecan plants with no cultivar data, together with Carya cathayensis and Juglans nigra. A total of 77 ISSR and 19 SSR primers were prescreened; 10 ISSR and eight SSR primers were selected, yielding a total of 94 amplified bands (100% polymorphic) in the range of 140–1,950 bp for the ISSR and 70 amplified bands (100% polymorphic) in the range of 50–350 bp for SSR markers. Genetic diversity analyses indicated Chinese-grown pecan cultivars and fine plants had significant diversity at the DNA level. The dengrograms constructed with ISSR, SSR or combined data were very similar, but showed very weak grouping association with morphological characters. However, the progeny were always grouped with the parents. The great diversity found among the Chinese cultivars and the interesting germplasm of the fine pecan plants analyzed in this study are very useful for increasing the diversity of the pecan gene pool. All 77 accessions in this study could be separated based on the ISSR and SSR fingerprints produced by one or more primers. The results of our study also showed that ISSR and SSR techniques were both suitable for genetic diversity analyses and the identification of pecan resources.
Methane oxidation potential of the arctic wetland soils of a taiga-tundra ecotone in northeastern Siberia

ABSTRACT Arctic wetlands are significant sources of atmospheric methane and the observed accelerated climate changes in the arctic could cause a change in methane dynamics. Methane oxidation would be the key process to control methane emission from wetlands. In this study, we determined the potential methane oxidation rate of the wetland soils of a taiga–tundra transition zone in northeastern Siberia. Peat soil samples were collected in summer from depressions covered with tussocks of sedges and Sphagnum spp. and from mounds vegetated with moss and larch trees. An aerobic bottle incubation experiment demonstrated that the soil samples collected from depressions in the moss- and sedge-dominated zones exhibited active methane oxidation with no time lag, while the mound soils showed no methane oxidation under the given conditions. The potential methane oxidation rates of the soils at 15°C ranged from 94 to 496 nmol h−1 g−1 dw. The immediate and active methane oxidation was observed over the depths studied (0–40 cm) including the water-saturated anoxic layers; the maximum methane oxidation rate was recorded in the layer above the water-saturated layer. The methane oxidation rate was temperature-dependent, but substantial methane oxidation was observed even at 0°C particularly for the moss soil samples. Soil samples collected from the frozen layer of Sphagnum peat also showed immediate methane consumption when incubated at 15°C. The present results suggest that the methane oxidizing bacteria in the wetland soils could survive under anoxic and frozen conditions keeping their potential activities and immediately utilize methane when the conditions become favorable. On the other hand, the inhibitor of methane oxidation (difluoromethane) did not affect the methane flux from the sedge and moss zones in situ, which suggested the minor role of plant-associated methane oxidation.
Analysis of Tumor Suppressor Genes Based on Gene Ontology and the KEGG Pathway

Cancer is a serious disease that causes many deaths every year. We urgently need to design effective treatments to cure this disease. Tumor suppressor genes (TSGs) are a type of gene that can protect cells from becoming cancerous. In view of this, correct identification of TSGs is an alternative method for identifying effective cancer therapies. In this study, we performed gene ontology (GO) and pathway enrichment analysis of the TSGs and non-TSGs. Some popular feature selection methods, including minimum redundancy maximum relevance (mRMR) and incremental feature selection (IFS), were employed to analyze the enrichment features. Accordingly, some GO terms and KEGG pathways, such as biological adhesion, cell cycle control, genomic stability maintenance and cell death regulation, were extracted, which are important factors for identifying TSGs. We hope these findings can help in building effective prediction methods for identifying TSGs and thereby, promoting the discovery of effective cancer treatments.
Rice Acreage Estimation in Thanjavur, Tamil Nadu Using Lands at 8 OLIIMAGES and GIS Techniques

Rice (Oryza sativa L.) is one of the most important food crops in the world occupying about 140 million hectares, feeding more than 50% of the world’s population (Khush, 2005). Asia accounts for 90% of the world’s rice production and consumption because of its favourable hot and humid climate. Rice crop grows between 55 0 N and 36 0 S latitudes under diverse conditions like flooded, irrigated and rain fed ecosystems. India contributed 21 per cent (155.4 million tonnes) of world’s rice production (738.2 million tonnes) during 2015 (FAO, 2016). Tamil Nadu has produced 79.14 lakh tonnes of rice from an area of 18.3 lakh hectares in 2014-15 (Vaithilingam, 2015). Timely and accurate estimation of rice areas and forecasting its production can provide vital information for governments, planners, and decision makers in formulating policies with respect to import/ export in the event of shortfall or surplus (Mostafa, 2015). Rice mapping during 1980s to early 1990s was mainly based on agricultural statistical data updated on regular time-intervals (Huke International Journal of Current Microbiology and Applied Sciences ISSN: 2319-7706 Volume 6 Number 7 (2017) pp. 2327-2335 Journal homepage: http://www.ijcmas. com
Diminished Expression and Function of TLR in Lymphatic Filariasis: A Novel Mechanism of Immune Dysregulation

Lymphatic filariasis is a disease characterized by immune dysregulation involving APC and T cell populations. To assess the contribution of TLR in mediating this dysregulation, we examined the expression of TLR1, TLR2, TLR4, and TLR9 on B cells and monocytes of filaria-infected and uninfected individuals. Baseline expression of TLR was significantly lower in B cells but not in monocytes of the filaria-infected group compared with the uninfected group. Upon stimulation with filarial Ag, a diminished up-regulation of TLR was observed in both B cells and monocytes of infected individuals. Finally, stimulation of B cells and monocytes with TLR ligands resulted in decreased B cell and monocyte activation/cytokine production, indicating a state of immune tolerance. This dysregulation is associated with diminished CD4+ T cell production of IFN-γ and IL-5. The diminished expression and function of TLR is thus a likely consequence of chronic Ag stimulation and could serve as a novel mechanism underlying the dysfunctional immune response in filariasis.
Advanced Glycation Endproducts Induce Changes in Glucose Consumption, Lactate Production, and ATP Levels in SH-SY5Y Neuroblastoma Cells by a Redox-Sensitive Mechanism

Advanced glycation endproducts (AGEs) accumulate on long-lived proteins, including β-amyloid plaques in Alzheimer's disease, and are suggested to contribute to neuronal dysfunction and cell death. We have investigated the effects of a model AGE upon glucose metabolism and energy production in a neuroblastoma cell line. AGEs decrease cellular ATP levels and increase glucose consumption and lactate production. All of the AGE-induced metabolic changes can be attenuated by antioxidants such as (R+)-α-lipoic acid and 17β-estradiol. These antioxidants may become useful drugs against (AGE-mediated) effects in neurodegeneration through their positive effects on cellular energy metabolism.
Fast and Robust Numerical Solution of the Richards Equation in Homogeneous Soil

We derive and analyze a solver-friendly finite element discretization of a time discrete Richards equation based on Kirchhoff transformation. It can be interpreted as a classical finite element discretization in physical variables with nonstandard quadrature points. Our approach allows for nonlinear outflow or seepage boundary conditions of Signorini type. We show convergence of the saturation and, in the nondegenerate case, of the discrete physical pressure. The associated discrete algebraic problems can be formulated as discrete convex minimization problems and, therefore, can be solved efficiently by monotone multigrid methods. In numerical examples for two and three space dimensions we observe $L^2$-convergence rates of order $\mathcal{O}(h^2)$ and $H^1$-convergence rates of order $\mathcal{O}(h)$ as well as robust convergence behavior of the multigrid method with respect to extreme choices of soil parameters.
Salicylic Acid Diminishes Staphylococcus aureus Capsular Polysaccharide Type 5 Expression

ABSTRACT Capsular polysaccharides (CP) of serotypes 5 (CP5) and 8 (CP8) are major Staphylococcus aureus virulence factors. Previous studies have shown that salicylic acid (SAL), the main aspirin metabolite, affects the expression of certain bacterial virulence factors. In the present study, we found that S. aureus strain Reynolds (CP5) cultured with SAL was internalized by MAC-T cells in larger numbers than strain Reynolds organisms not exposed to SAL. Furthermore, the internalization of the isogenic nonencapsulated Reynolds strain into MAC-T cells was not significantly affected by preexposure to SAL. Pretreatment of S. aureus strain Newman with SAL also enhanced internalization into MAC-T cells compared with that of untreated control strains. Using strain Newman organisms, we evaluated the activity of the major cap5 promoter, which was significantly decreased upon preexposure to SAL. Diminished transcription of mgrA and upregulation of the saeRS transcript, both global regulators of CP expression, were found in S. aureus cultured in the presence of SAL, as ascertained by real-time PCR analysis. In addition, CP5 production by S. aureus Newman was also decreased by treatment with SAL. Collectively, our data demonstrate that exposure of encapsulated S. aureus strains to low concentrations of SAL reduced CP production, thus unmasking surface adhesins and leading to an increased capacity of staphylococci to invade epithelial cells. The high capacity of internalization of the encapsulated S. aureus strains induced by SAL pretreatment may contribute to the persistence of bacteria in certain hosts.
Effect of climate change on vegetation phenology of different land-cover types on the Tibetan Plateau

ABSTRACT Research in vegetation phenology change has been one heated topic of current ecological and climate change study. The Tibetan Plateau, as the highest plateau of the earth, is more vulnerable and sensitive to climate change than many other regions. In this region, shifts in vegetation phenology have been intensively studied during recent decades, primarily based on satellite-retrieved data. In this study, we explored the spatiotemporal changes of vegetation phenology for different land-cover types in the Tibetan Plateau and characterized their relationship with temperature and precipitation by using long-term time-series datasets of normalized difference vegetation index (NDVI) from 1982 to 2014. Diverse phenological changes were observed for different land-cover types, with an advancing start of growing season (SOS), delaying end of growing season (EOS) and increasing length of growing season (LOS) in the eastern Tibetan Plateau where meadow was the dominant vegetation type, but with the opposite changes in the steppe and sparse herbaceous or sparse shrub regions which are mostly located in the northwestern and western edges of the Tibetan Plateau. Correlation analysis indicated that sufficient preseason precipitation may delay the SOS of evergreen forests in the southeastern Plateau and advance the SOS of steppe and sparse herbaceous or sparse shrub in relatively arid areas, while the advance of SOS in meadow areas could be related to higher preseason temperature. For EOS, because it is less sensitive to climate change than SOS, the response of EOS for different land-cover types to precipitation and temperature were more complicated across the Tibetan Plateau.
Variability in immune response to pathogens: using measles vaccine to probe immunogenetic determinants of response.

“The measles had not prevailed on the Faroes since 1781; they broke out early in April, 1846. … of the 7,782 inhabitants, about 6,000 were taken with measles … 225 persons in all died … of the many old people still living on the Faroes who had had the measles in 1781, not one … was attacked the second time. ” [P. L. Panum, Observations Made during the Epidemic of Measles on the Faroe Islands in the Year 1846]
On generating EEG for controlling musical systems

The objective of our research is to develop Brain-Computer Interfacing (BCI) for musical applications. This paper reviews initial work on protocols to generate EEG data associated with musical imagination. The paper presents two experiments (referred to as auditory imagery and musical focusing, respectively). The results strongly suggest that it is possible to design effective protocols to detect EEG associated with musical mental tasks for a BCI system.
Design of optimal convolutional codes for joint decoding of correlated sources in wireless sensor networks

We consider a wireless sensors network scenario where two nodes detect correlated sources and deliver them to a central collector via a wireless link. Differently from the Slepian-Wolf approach to distributed source coding, in the proposed scenario the sensing nodes do not perform any pre-compression of the sensed data. Original data are instead independently encoded by means of low-complexity convolutional codes. The decoder performs joint decoding with the aim of exploiting the inherent correlation between the transmitted sources. Complexity at the decoder is kept low thanks to the use of an iterative joint decoding scheme, where the output of each decoder is fed to the other decoder's input as a-priori information. For such scheme, we derive a novel analytical framework for evaluating an upper bound of joint-detection packet error probability and for deriving the optimum coding scheme. Experimental results confirm the validity of the analytical framework, and show that recursive codes allow a noticeable performance gain with respect to non-recursive coding schemes. Moreover, the proposed recursive coding scheme allows to approach the ideal Slepian-Wolf scheme performance in AWGN channel, and to clearly outperform it over fading channels on account of diversity gain due to correlation of information.
Ray Tracing Technique based 60 GHz Band Propagation Modelling and Influence of People Shadowing

—The main objectif of this paper is to present a tool that we have developed subject to characterize and modelling indoor radio channel propagation at millimetric wave. The tool is based on the ray tracing technique (RTT). As, in realistic environment we cannot neglect the signiﬁcant impact of Human Body Shadowing and other objects in motion on indoor 60 GHz propagation channel. Hence, our proposed model allows a simulation of propagation in a dynamic indoor environment. First, we describe a model of human body. Second, RTT with this model is used to simulate the propagation of millimeter waves in the presence of persons in motion. Results of the simulation show that this tool gives results in agreement with those reported in the literature. Specially, the effects of people motion on temporal channel properties.