Miracle-dz/UniFAR-FTUs huggingface dataset:
The emotional turn in higher education: a psychoanalytic contribution

ABSTRACT This article contributes to contemporary debates about the significance of emotions within Higher Education. Using a psychoanalytic lens we analyse the ways in which experiences of anxiety and tension are essential for learning. The anxiety associated with learning can stimulate meaningful and reflexive outcomes but ‘learning inaction’ [Vince, R. 2014. ‘What Do HRD Scholars and Practitioners Need to Know About Power, Emotion, and HRD? ’ Human Resource Development Quarterly 25: 409–420] is also possible. In adopting a psychoanalytical lens we assert the agency of both learners and teachers in scholarly relationships and we draw attention to the emotions of educators as well as students. This has important implications for teacher education and academic formation activities.
(Non-)existence of Wilson bases for general time-frequency lattices

Motivated by a recent generalization of the Balian-Low theorem and by new research in wireless communications we analyze the construction of Wilson bases for general time-frequency lattices. We show that orthonormal Wilson bases for L(R) can be constructed for any time-frequency lattice whose volume is 1 2 . While this may be expected, our second result may come as a surprise. Namely we prove that there cannot exist Wilson bases (orthogonal or non-orthogonal) for general non-rectangular time-frequency lattices for l(Z) nor for the finite case C. These results should be compared to the fact that tight Gabor frames for general time-frequency lattices exist in abundance for L(R), l(Z), and C. We discuss some practical consequences of our theoretical findings.
Validation of a clinical prediction rule for the differentiation between septic arthritis and transient synovitis of the hip in children.

BACKGROUND The differentiation between septic arthritis and transient synovitis of the hip in children can be difficult. The purpose of the present study was to validate a previously published clinical prediction rule for this differentiation in a new patient population. METHODS We prospectively studied children who presented to a major children's hospital between 1997 and 2002 with an acutely irritable hip. As in the previous study, diagnoses of septic arthritis (fifty-one patients) and transient synovitis (103 patients) were operationally defined on the basis of the white blood-cell count in the joint fluid, the results of cultures of joint fluid and blood, and the clinical course. Univariate analysis and multiple logistic regression were used to compare the two groups. The predicted probability of septic arthritis of the hip from the prediction rule was compared with actual distributions in the current patient population. The area under the receiver operating characteristic curve was determined. RESULTS The same four independent predictors of septic arthritis of the hip (a history of fever, non-weight-bearing, an erythrocyte sedimentation rate of 40 mm/hr, and a serum white blood-cell count of >12,000 cells/mm(3) (>12.0 x 10(9)/L)) were identified in the current patient population. The predicted probability of septic arthritis of the hip from the prediction rule was similar to the actual distributions in the current patient population. The area under the receiver operating characteristic curve for the current patient population was 0.86, compared with 0.96 in the original population. CONCLUSIONS Clinical prediction rules typically demonstrate diminished performance in a new patient population because they are optimally modeled to the original data set. The previously published clinical prediction rule for the differentiation between septic arthritis and transient synovitis of the hip in children demonstrated diminished, but nevertheless very good, diagnostic performance in a new patient population.
Reliability and Validity of Chinese Version of Optimism and Pessimism Scale in Chinese College Students

Objective: To examine the reliability and validity of the Chinese version of the Optimism and Pessimism Scale (OPS -C) in Chinese college students. Methods: The questionnaire was administered to 540 college students. Results: The internal consistency reliability of the total score, optimism and pessimism subscale was 0.819, 0.791 and 0.751; and four-week test-retsest reliability coefficient was 0.724, 0.681 and 0.573; inter-item mean correlations was 0.115, 0.175 and 0.150; infraclass correlation coefficients (ICC) was 0.721, 0.630 and 0.493. The correlation coefficients between the total of the scale, optimism and pessimism subscale was 0.825, -0.803 and -0.330 respectively. The total and subscale of OPS -C had moderate correlation with corresponding scale of depression, anxiety, positive and negative emotion, life satisfaction and coping. And the results of confirmatory factor analyses (χ2/df=2.201, GFI=0.875, AGFI= 0.858, RMSEA=0.047) indicated that the two-factor structure of the OPS-C was suitable for the Chinese college students. Conclusion: The OPS-C with acceptable psychometric quality.
A Preliminary Comparison of the Thrombogenic Activity of Vitronectin and Other RGD‐containing Proteins When Bound to Surfaces a

Recently several proteins that share no extensive homology with one a n 0 t x have been shown to interact with a set of homologous receptors on the surfaces of cells. The proteins, called “cell adhesion proteins,” have two features in common: they each contain the sequence arginine-glycine-aspartic acid (RGD in the one-letter amino acid code) and the propensity to become deposited into the connective tissue matrix. The implication of this latter property is that the cell adhesion proteins are also structural proteins. Well-described examples of such proteins are found in blood plasma: fibronectin, vitronectin, von Willebrand factor, and fibrinogen. The cell surface receptors, called “integrins”’ or “cytoadhesin~,”~ are heterodimers of a and @ subunits. The a subunits are 130,000-170,000 daltons and are unique for each receptor, whereas @ subunits are 90,000-1 10,000 daltons and apparently have the capacity to bind to several different a subunits; thus a given (3 subunit can be found in a variety of receptors. The integrin-cell adhesion protein systems are thought to mediate the positioning and movement of cells. In support of this thesis, small tetraor pentapeptides that contain the RGD sequence possess remarkable properties. ’ The peptides inhibit processes as diverse as gastrulation, neural crest migration, migration of prethymocytes into the embryonic thymus, platelet aggregation, cancer metastasis, and locomotion of slime mold. It is reasonable to conclude that the peptides work by binding to integrins and blocking the interaction of integrins with cognate cell adhesion proteins. Over the past 7 years, we have used a canine ex vivo experimental model to characterize effects that various preadsorbed plasma proteins exert on thrombogenesis induced by candidate polymeric materialsu and to assess the intrinsic acute thrombogenicity possessed by these materials. ’ Among the proteins that have been studied are fibronectin, von Willebrand factor, fibrinogen, and in recent preliminary investigations, vitronectin. In this paper the properties of vitronectin are briefly reviewed and the effects of vitronectin in the canine model described.
Measurement of Inositol 1,4,5-Trisphosphate in Living Cells Using an Improved Set of Resonance Energy Transfer-Based Biosensors

Improved versions of inositol-1,4,5-trisphosphate (InsP 3) sensors were created to follow intracellular InsP 3 changes in single living cells and in cell populations. Similar to previous InsP 3 sensors the new sensors are based on the ligand binding domain of the human type-I InsP 3 receptor (InsP3R-LBD), but contain a mutation of either R265K or R269K to lower their InsP 3 binding affinity. Tagging the InsP 3R-LBD with N-terminal Cerulean and C-terminal Venus allowed measurement of InsP 3 in single-cell FRET experiments. Replacing Cerulean with a Luciferase enzyme allowed experiments in multi-cell format by measuring the change in the BRET signal upon stimulation. These sensors faithfully followed the agonist-induced increase in InsP 3 concentration in HEK 293T cells expressing the Gq-coupled AT1 angiotensin receptor detecting a response to agonist concentration as low as 10 pmol/L. Compared to the wild type InsP 3 sensor, the mutant sensors showed an improved off-rate, enabling a more rapid and complete return of the signal to the resting value of InsP 3 after termination of M3 muscarinic receptor stimulation by atropine. For parallel measurements of intracellular InsP 3 and Ca2+ levels in BRET experiments, the Cameleon D3 Ca2+ sensor was modified by replacing its CFP with luciferase. In these experiments depletion of plasma membrane PtdIns(4,5)P 2 resulted in the fall of InsP 3 level, followed by the decrease of the Ca2+-signal evoked by the stimulation of the AT1 receptor. In contrast, when type-III PI 4-kinases were inhibited with a high concentration of wortmannin or a more specific inhibitor, A1, the decrease of the Ca2+-signal preceded the fall of InsP 3 level indicating an InsP 3-, independent, direct regulation of capacitative Ca2+ influx by plasma membrane inositol lipids. Taken together, our results indicate that the improved InsP 3 sensor can be used to monitor both the increase and decrease of InsP 3 levels in live cells suitable for high-throughput BRET applications.
Food habits in a southern Italian town (Nicotera) in 1960 and 1996: still a reference Italian Mediterranean diet?

BACKGROUND A follow-up analysis of cohorts surveyed in the "Seven Countries Study" has provided increasing evidence of an association between diet and morbidity or mortality from coronary heart disease (CHD) and cancer. The effects of the "Mediterranean diet" on mortality is still evident in Italy, where food patterns differ significantly in different geographical areas. OBJECTIVE To examine differences in food habits in Nicotera, one of the Italian rural areas of the Seven Countries Study, between 1960 and 1996. METHODS In 1996, 80 subjects, 37 females and 43 males, aged 40-59 years, were examined in Nicotera assessing food intake by means of a semiquantitative questionnaire of food frequency, validated for the Italian population. In 1960, food intake of a sample of Nicotera subjects was assessed by weighed record method for three seasons. RESULTS Food choices differed markedly between 1960 and 1996. Consumption of animal foods increased, as did that of cakes, pies and cookies and sweet beverages in both male and female groups; an increase of alcoholic beverages was observed only in females. CONCLUSIONS In 1960, Nicotera inhabitants were following a diet defined as a "reference Italian Mediterranean diet", but by 1996 the Nicotera diet approached that of an average Italian diet, whose characteristics fall short of a true Mediterranean diet. This change in dietary habits may be responsible for an increased risk of CHD and cancer in the general population in the absence of other factors.
Determination of Accessory Gene Patterns Predicts the Same Relatedness among Strains of Streptococcus pneumoniae as Sequencing of Housekeeping Genes Does and Represents a Novel Approach in Molecular Epidemiology

ABSTRACT Relatedness between isolates of Streptococcus pneumoniae can be determined from sequences of multiple genes belonging to the core genome (multilocus sequence typing [MLST]), but these do not provide information on gene content that may affect the potential of isolates to cause invasive pneumococcal disease. Gene content data, obtained using microarrays, were gathered for 40 clinical isolates of 12 serotypes belonging to 30 multilocus sequence types. We found that sequence variations in housekeeping genes assessed by MLST correlated well with whole-genome microarray analyses identifying the presence/absence of accessory genes/regions. However, isolates belonging to the same clonal complex, as determined by MLST, may not have identical gene contents, potentially affecting virulence. We found fewer intraclonal (same MLST sequence type) differences associated with pneumococcal serotypes of high invasive disease potential, i.e., serotypes rarely found among carriers compared to serotypes frequently found in carriage. Molecular typing of pneumococci based on the presence/absence of 25 genes localized to accessory regions shows the same relatedness among pneumococcal strains as MLST does. We conclude that molecular typing of pneumococci based on variation in the nucleotide sequences of parts of housekeeping genes (MLST) correlates with the presence/absence of genes in the accessory part of the genome. This covariation is likely due to the fact that both sequence variations and gene content variations are created primarily by recombination events in pneumococci.
Association between mobile phone addiction and mental health among college students

Objective In order to explore the association between mobile phone addiction and mental health among college students,this study aimed at investigating the related basic status of mental health education.Methods By using stratified cluster sampling method,investigation was conducted among 1 172 subjects.They were assessed with the Mobile Phone Addiction Index Scale and Symptom Checklist 90(SCL-90). Results The rate of mobile phone addiction was 15.4%. There was significant difference in gender or major(P 0.05). Mobile phone addiction score of students majoring in arts or girls was higher.Mobile phone addiction was correlated with the total score of SCL-90 and the score of nine factors(P 0.01). Moreover,anxious,psychotic,obsessive-compulsive and terror had the significant prediction function on mobile phone addiction(Beta = 0.22,0.11,0.10,0.08). Conclusion There is different mental health problems in mobile phone addicts.It suggests that mental health might be important variable to influence mobile phone addiction in college students.
A Prediction Model for Lung Cancer Diagnosis that Integrates Genomic and Clinical Features

Abstract Lung cancer is the leading cause of cancer death due, in part, to lack of early diagnostic tools. Bronchoscopy represents a relatively noninvasive initial diagnostic test in smokers with suspect disease, but it has low sensitivity. We have reported a gene expression profile in cytologically normal large airway epithelium obtained via bronchoscopic brushings, which is a sensitive and specific biomarker for lung cancer. Here, we evaluate the independence of the biomarker from other clinical risk factors and determine the performance of a clinicogenomic model that combines clinical factors and gene expression. Training (n = 76) and test (n = 62) sets consisted of smokers undergoing bronchoscopy for suspicion of lung cancer at five medical centers. Logistic regression models describing the likelihood of having lung cancer using the biomarker, clinical factors, and these data combined were tested using the independent set of patients with nondiagnostic bronchoscopies. The model predictions were also compared with physicians' clinical assessment. The gene expression biomarker is associated with cancer status in the combined clinicogenomic model (P < 0.005). There is a significant difference in performance of the clinicogenomic relative to the clinical model (P < 0.05). In the test set, the clinicogenomic model increases sensitivity and negative predictive value to 100% and results in higher specificity (91%) and positive predictive value (81%) compared with other models. The clinicogenomic model has high accuracy where physician assessment is most uncertain. The airway gene expression biomarker provides information about the likelihood of lung cancer not captured by clinical factors, and the clinicogenomic model has the highest prediction accuracy. These findings suggest that use of the clinicogenomic model may expedite more invasive testing and definitive therapy for smokers with lung cancer and reduce invasive diagnostic procedures for individuals without lung cancer.
Density estimation by wavelet thresholding

Density estimation is a commonly used test case for nonparametric estimation methods. We explore the asymptotic properties of estimators based on thresholding of empirical wavelet coefficients. Minimax rates of convergence are studied over a large range of Besov function classes B σpq and for a range of global L' p error measures, 1 ≤ p' p, some form of nonlinearity is essential, since the minimax linear estimators are suboptimal by polynomial powers of n. A second approach, using an approximation of a Gaussian white-noise model in a Mallows metric, is used to attain exactly optimal rates of convergence for quadratic error (p' = 2).
Agency in Assistive Technology Adoption: Visual Impairment and Smartphone Use in Bangalore

Studies on technology adoption typically assume that a user's perception of usability and usefulness of technology are central to its adoption. Specifically, in the case of accessibility and assistive technology, research has traditionally focused on the artifact rather than the individual, arguing that individual technologies fail or succeed based on their usability and fit for their users. Using a mixed-methods field study of smartphone adoption by 81 people with visual impairments in Bangalore, India, we argue that these positions are dated in the case of accessibility where a non-homogeneous population must adapt to technologies built for sighted people. We found that many users switch to smartphones despite their awareness of significant usability challenges with smartphones. We propose a nuanced understanding of perceived usefulness and actual usage based on need-related social and economic functions, which is an important step toward rethinking technology adoption for people with disabilities.
Deficits in the miRNA-34a-regulated endogenous TREM2 phagocytosis sensor-receptor in Alzheimer's disease (AD); an update

One characteristic feature of Alzheimer's disease (AD) neuropathology is the progressive generation, aggregation and deposition of the 42 amino acid amyloid beta (Aβ42) peptide, and other related amyloidogenic molecules, into dense clumps of insoluble, pro-inflammatory senile plaque cores in the extracellular space of the brain. It is not generally appreciated that the Aβ42 peptide, derived via tandem beta-gamma secretase cleavage of the larger ~770 amino acid transmembrane beta-amyloid precursor protein (βAPP) is one of the “stickiest” peptides known, due in part to its high content of lipophillic and hydrophobic peptide domains (21.4% valine-isoleucine; Mager, 1998; Watson et al., 2005). Aβ42 peptide monomers have tremendously high potential for relatively rapid self-aggregation into Aβ42 peptide dimers and higher order fibrillar structures via long-range, non-covalent hydrophobic forces that over time promote β-pleated sheet conformations (Mager, 1998; Watson et al., 2005; Boutajangout and Wisniewski, 2013; Chang et al., 2013). There is abundant evidence that under normal, homeostatic conditions, Aβ42 peptide monomers and perhaps other higher order Aβ42 peptides are effectively “cleared” from the brain's extracellular medium by highly active and efficient innate-immune surveillance and phagocytic systems that limit excessive Aβ42 peptide dimerization, accumulation and further self-aggregation into pathological senile plaque lesions. Recently described, one of the key phagocytosis sensor-receptors responsible for Aβ42 peptide clearance from the human central nervous system (CNS) is very likely the triggering receptor expressed in myeloid/microglial cells 2 (TREM2) enriched in myeloid cells and microglial cells of the CNS (Benitez et al., 2013; Forabosco et al., 2013; Gonzalez Murcia et al., 2013; Guerreiro et al., 2013; Neumann and Daly, 2013; Zhao et al., 2013; Jones et al., 2014; Figure ​Figure1). 1). This short paper is an update on some very recent observations on TREM2 neurobiology, on newly discovered roles for miRNA-34a-mediated signaling in human degenerative disease, including miRNA-34a-mediated effects on TREM2 expression, and how dysfunctional TREM2 signaling may contribute to amyloidogenesis in AD and in related progressive, inflammatory neurodegenerative diseases of the human CNS.
Evaluation Of Hypoglycemic Potential Of Extracts Of Balanites Aegyptiaca Parts

Medicinal plants have been employed in the management of diabetes and are well recognized as important source of new drug (Newman and Cragg, 2007). Polyphenols are molecules from plants that represent a wide range of substances with various structures. Evidence from several in vitro, animal model and human studies have provided the rationale for the use of polyphenols in disease interventions (Sasidharan et al., 2011; Atawodi et al., 2011; Wang et al., 2013; Tain et al., 2013). The plant ‘Balanites aegyptiaca Del. ’, also known as ‘desert date’ in English, a member of Zygophyllaceae family, is a common plant species of the dry land areas of Africa and Asia (Hall and Waijer, 1991; Hall, 1992). In Nigeria, it is found in abundant in the Northern region. It is known as ‘Aduwa’ in Hausa, ‘Utazi’ in Igbo, and ‘Teji’ in Yoruba. Literature survey revealed that B. aegyptiaca has a long history of traditional uses for wide ranges of disease including diabetes (Daya and Vegahasiya, 2011). Phytochemical investigation of Balanites aegyptiaca parts revealed the presence of various polyphenols; coumarins and quercetins were found in the leaves, alkaloids and coumarins were seen in the stem-bark while rutins was found in the fruit among others (Salwa et al., 1988; Sarker et al., 2000) [27,28]. In a bid to identify the part that exhibit better antidiabetic activity and hence promote the use and acceptance of the plant as antidiabetic remedy, this study attempt to identify Balanites aegyptiaca parts with better antidiabetic activity. Abstract: This study was aimed to evaluate hypoglycemic potential of extracts of Balanites aegyptica leaves, stembark and fruit-mesocarp. Balanites aegyptiaca leaves, stem-bark and fruit-mesocarp were extracted using ethanol followed by solvent-solvent fractionation with ethyl acetate and water. The solvent-fractions thus obtained were subjected to acute oral toxicity study on wistar rats. Phenolics and flavoniods content of the fractions were assayed. Solventfractions were evaluated in vivo in pursuit for those with hypoglycemic property. The solvent-fractions were orally administered at a dose of 400 mg/kg body wt. (i.e.1/10 th of lethal dose) to normoglycemic/diabetic rats, positive control were given metformin (200 mg/kg body wt.) and negative controls received 10 % dimethyl sulfurdioxide (DMSO). Results obtained showed no death or lethal effect in the acute oral toxicity study up to a dose of 4000 mg/kg body wt. therefore, the LD50 value was considered to be greater than 4000 mg/kg body wt. Phenolics and flavoniods content showed varying levels; phenolics was highest compared to flavonoids in all the solvent-fractions. Acute effect of solvent-fractions on fasting blood sugar and oral glucose loaded test in normoglycemic/diabetic rats showed hypoglycemic effects. In sum, these results indicated that phenolics and flavonoids in Balanites aegyptiaca leaves, stem-bark and fruit-mesocarp exhibit antidiabetic effect; leaves and fruit mesocarp showed the better activity.