Miracle-dz/UniFAR-FTUs huggingface dataset:
Proteomic analysis of grapevine resistance induced by Trichoderma harzianum T39 reveals specific defence pathways activated against downy mildew

Downy mildew is caused by the oomycete Plasmopara viticola and is one of the most serious diseases of grapevine. The beneficial microorganism Trichoderma harzianum T39 (T39) has previously been shown to induce plant-mediated resistance and to reduce the severity of downy mildew in susceptible grapevines. In order to better understand the cellular processes associated with T39-induced resistance, the proteomic and histochemical changes activated by T39 in grapevine were investigated before and 1 day after P. viticola inoculation. A comprehensive proteomic analysis of T39-induced resistance in grapevine was performed using an eight-plex iTRAQ protocol, resulting in the identification and quantification of a total of 800 proteins. Most of the proteins directly affected by T39 were found to be involved in signal transduction, indicating activation of a complete microbial recognition machinery. Moreover, T39-induced resistance was associated with rapid accumulation of reactive oxygen species and callose at infection sites, as well as changes in abundance of proteins involved in response to stress and redox balance, indicating an active defence response to downy mildew. On the other hand, proteins affected by P. viticola in control plants mainly decreased in abundance, possibly reflecting the establishment of a compatible interaction. Finally, the high-throughput iTRAQ protocol allowed de novo peptide sequencing, which will be used to improve annotation of the Vitis vinifera cv. Pinot Noir proteome.
Predicting mergers and acquisitions in the food industry

Two logit models are estimated to explain merger and acquisition (M&A) activities in US food manufacturing using firm level data for public firms: a “target model” predicting the likelihood of a firm being targeted for M&A and a “takeover model” predicting the likelihood of a targeted firm being taken over. Target model results suggest the importance of firm liquidity, debt|leverage, profitability, growth in sales, stock earnings capacity, percentage of common stocks traded in the stock market, and market-to-book ratio. Activity or turnover ratio, firm size, and price-earnings ratio were not statistically significant. Takeover model results suggest the importance of degree of officer control, attitude surrounding the transaction, number of prior bids, existence of litigation during negotiations, and involvement of the bidder and|or target in other takeovers during negotiations. With predictive accuracy of 74.5 and 62.9%, respectively, these models suggest the systematic nature of M&A activities. © 1999 John Wiley & Sons, Inc.
Theory of the Beautiful Game: The Unification of European Football

European football is in a spiral of intra-league and inter-league polarization of talent and wealth. The invariance proposition is revisited with adaptations for win-maximizing sportsman owners facing an uncertain Champions League prize. Sportsman and champion effects have driven European football clubs to the edge of insolvency and polarized competition throughout Europe. Revenue revolutions and financial crises of the Big Five leagues are examined and estimates of competitive balance are compared. The European Super League completes the open-market solution after Bosman. A 30-team Super League is proposed based on the National Football League.
Behavioural and Energetic Responses to Body State in Male and Female Barn Swallows (Hirundo rustica)

Abstract Females and males often have different roles when attending young. The factors responsible for shifts in the balance of effort when both sexes provision their young are not clear. This study asked if sex-specific behaviour and provisioning rules in barn swallows (Hirundo rustica) were dependent on individual body-state or affected by the state of their provisioning partner. To assess this male and female barn swallows underwent overnight warming manipulations whilst provisioning 10–14 day old nestlings, a time when energetic demands are maximal. The overnight warming treatment reduced thermoregulatory costs and provided birds with extra energy reserves at dawn. Only one member of a pair was manipulated in this way, whilst their partners were left un-manipulated to assess their response to their partner's elevated body-state. The energetic and behavioural responses to these manipulations were followed over the subsequent 24-h. I found that warmed male and female barn swallows increased their energy expenditure and nest visitation rates to the same extent after manipulation, implying a trade-off in resource allocation, which was biased towards reproductive effort. There was no effect of gender. Males paired with manipulated females showed no energetic or behavioural adjustments, however, females paired with manipulated males tended to increase both energy expenditure and nest visitation. This study provides evidence that energy reserves constrain behaviour, and that male and female swallows normally follow the same state-dependent rules when provisioning young.
Is There a Causal Effect of Working Part‐Time on Current and Future Wages?

In this paper, I study the causal effects of part‐time work on current and future wages. To estimate these effects, I use a random effects model with a wage equation capturing the employment history and a dynamic multinomial probit component for the choice of employment status. Exclusion restrictions from the institutional context are exploited to support identification. The results suggest that working part‐time with few hours has a large causal effect on current wages, but more extensive part‐time work does not reduce current wages. However, both types of part‐time work lead to negative long‐term wage effects.
Accumulation of External Reserves and Effects on Exchange Rates and Inflation in Nigeria

The study is to find out the effects of holding Foreign Exchange reserves on Exchange Rates in Nigeria. It is also to find out the effect of such reserves on inflation in Nigeria. Two hypotheses are proposed for the study. Hypothesis I has Null (H0) Hypothesis that foreign exchange reserves do not have significant effect on foreign exchange rate. There is the Hypothesis II where Null (H0) hypothesis is that foreign exchange reserves do not have significant effects on inflation in Nigeria. Secondary time series data are collated from CBN Statistical Bulletin. Simple linear regression was run for two models with Minitab 14 for windows. The regression equation shows that there is a negative relationship between Foreign Exchange rate leading to the rejection of first null hypothesis and accepting H1. The Second regression equation shows that inflation has positive relationship with foreign reserves. This means also rejecting second null hypothesis and accepting the second alternative hypothesis. Government is advised to ensure optimal management of the nations external reserves. Other causes such as Money Supply (M2) are suspected to be responsible for causing inflation in Nigeria. Key words: Foreign reserves; Foreign exchange; Balance of payments; Volatility; Guidotti–Greenspan rule; External shocks
Optimal Portfolio Allocation for Corporate Pension Funds

We model the asset allocation decision of a defined benefit pension fund using a stochastic dynamic programming approach. Our model recognizes the fact that asset allocation decisions are made by trustees who are mandated to act in the best interests of beneficiaries - not by sponsoring employers - and that trustees face payoffs that are linked in an indirect way to the value of the underlying assets. This is because of the presence of pension insurance - which may cover a portion of deficits in the event of a sponsor default - and a sponsoring employer who may make good any shortfall in assets, and who may reclaim some pension surplus. Our model includes an allowance for uncertainty both of the future value of assets (because of uncertain investment returns) and liabilities (because of uncertainty in future longevity and in future interest rates). We find that we are able to substantially replicate observed DB pension asset allocations in the UK and conclude that institutional details - in particular asymmetries in payoffs to pension trustees - are crucial in understanding pension asset allocation.
Homeopathic pathogenetic trials produce more specific than non-specific symptoms: results from two double-blind placebo controlled trials

We conducted two parallel, blinded homeopathic pathogenetic trials conducted at two different sites to determine whether symptoms reported by healthy volunteers were significantly different for homeopathic remedies than for placebos. Study 1 used a two-armed design, testing ozone against placebo. Study 2 used a three-armed design, testing ozone and iridium against placebo. We found significantly more remedy-specific symptoms in provers taking ozone or iridium than in provers taking placebo in the three-armed trial and in both trials pooled for ozone and placebo. We, therefore, conclude that homeopathic remedies produce more symptoms typical for a remedy than non-typical symptoms. The results furthermore suggest a somewhat non-classical pattern because symptoms of one remedy appear to be mimicked in the other trial arm. This might be indicative of entanglement in homeopathic systems.
The impact of HRM practices on organisational performance in the Indian hotel industry

Purpose – The study has a two‐fold purpose: to investigate whether some specific characteristics of hotels affect organisational performance in the hotel industry in India; and to investigate whether some HRM systems affect organisational performance in the hotel industry in India.Design/methodology/approach – A total of 439 hotels, ranging from three‐star to five‐star deluxe, responded to a self‐administered questionnaire that measured 27 HRM practices, five organisational performance variables, and ten demographic variables. Factor analysis was performed to identify HRM systems, one‐way ANOVA was employed to test the association of the demographic variables with organisational performance, and correlation analysis was used to test the relation between HRM systems and organisational performance.Findings – The results indicate that hotel performance is positively associated with hotel category and type of hotel (chain or individual). Furthermore, hotel performance is positively related to the HRM systems .
‘Can’t get no satisfaction?’ Evaluating the sale of the family business from the family's perspective and deriving implications for new venture activities

The scarce research on the sale of family businesses suggests that business-owning families take different factors into account than non-family owners when evaluating a business sale. This paper builds on a utility-oriented framework and analyses literature to identify the key factors that affect the family's appraisal of the sale. We integrate these factors into an explanatory model which shows that the family's evaluation of a business sale takes longer and is often different compared to a non-family business sale. In contrast to the paradigm of family business succession, our model advocates the exit option, which in a second step can foster new entrepreneurial family activity. We discuss how satisfaction might affect new venture activities and apply a case to show how our model can be generally used to analyse a family business sale.
Genotype-Phenotype Effects of Bmpr2 Mutations on Disease Severity in Mouse Models of Pulmonary Hypertension

More than 350 mutations in the type-2 BMP (bone morphogenetic protein) receptor, BMPR2, have been identified in patients with heritable pulmonary arterial hypertension (HPAH). However, only 30% of BMPR2 mutation carriers develop PAH, and we cannot predict which of these carriers will develop clinical disease. One possibility is that the nature of the BMPR2 mutation affects disease severity. This hypothesis has been difficult to test clinically, given the rarity of HPAH and the complexity of the confounding genetic and environmental risk factors. To test this hypothesis, therefore, we evaluated the susceptibility to experimental pulmonary hypertension (PH) of mice carrying different HPAH-associated Bmpr2 mutations on otherwise identical genetic backgrounds. Mice with Bmpr2ΔEx4–5 mutations (Bmpr2+/−), in which the mutant protein is not expressed, develop less severe PH in response to hypoxia or hypoxia with vascular endothelial growth factor receptor inhibition than mice with an extracellular-domain Bmpr2ΔEx2 mutation (Bmpr2ΔEx2/+), in which the mutant protein is expressed. This was associated with a marked decrease in stabilizing phosphorylation of threonine 495 endothelial nitric oxide synthase (pThr495 eNOS) in Bmpr2ΔEx2/+ compared to wild-type and Bmpr2+/− mouse lungs. These findings provide the first experimental evidence that BMPR2 mutation types influence the severity of HPAH and suggest that patients with BMPR2 mutations who express mutant BMPR2 proteins by escaping non-sense-mediated messenger RNA decay (NMD– mutations) will develop more severe disease than HPAH patients with NMD+ mutations who do not express BMPR2 mutant proteins. Since decreased levels of pThr495 eNOS are associated with increased eNOS uncoupling, our data also suggest that this effect may result from defects in eNOS function.
Does Conservatism Matter? A Time-Series Approach to Central Bank Behaviour

Empirical studies crediting 'independent and conservative central banks' with lowering inflation and inflation volatility have been criticised for their focus on policy outcomes instead of policies, and for their unsystematic conflation of independence and conservatism. We present results from time-series models for the German Bundesbank that avoid these shortfalls. Conservatism matters in the following sense: ("i"h) more conservative Bundesbank Councils tend to react stronger to changes in inflation and output, and ("ii"h) an increase in conservatism leads to a more activist stabilisation policy. This is in line with simple policy models incorporating economic persistence with implementation lags for monetary policy. Copyright 2005 Royal Economic Society.
Outline of a Theory of Statistical Estimation Based on the Classical Theory of Probability

We shall distinguish two aspects of the problems of estimation . (i) the practical and (ii) the theoretical. The practical aspect may be described as follows: (i a ) The statistician is concerned with a population, π, which for some reason or other cannot be studied exhaustively. It is only possible to draw a sample from this population which may be studied in detail and used to form an opinion the values of certain constants describing the properties of the population π. For example, it may be desired to calculate approximately the mean of a certain character possessed by the individuals forming the population π, etc.
Rules for DNA target-site recognition by a lactococcal group II intron enable retargeting of the intron to specific DNA sequences.

Group II intron homing occurs primarily by a mechanism in which the intron RNA reverse splices into a DNA target site and is then reverse transcribed by the intron-encoded protein. The DNA target site is recognized by an RNP complex containing the intron-encoded protein and the excised intron RNA. Here, we analyzed DNA target-site requirements for the Lactococcus lactis Ll.LtrB group II intron in vitro and in vivo. Our results suggest a model similar to yeast mtDNA introns, in which the intron-encoded protein first recognizes a small number of nucleotide residues in double-stranded DNA and causes DNA unwinding, enabling the intron RNA to base-pair with the DNA for reverse splicing. Antisense-strand cleavage requires additional interactions between the protein and 3' exon. Key nucleotide residues are recognized directly by the intron-encoded protein independent of sequence context, and there is a stringent requirement for fixed spacing between target site elements recognized by the protein and RNA components of the endonuclease. Experiments with DNA substrates containing GC-clamps or "bubbles" indicate a requirement for DNA unwinding in the 3' exon but not the distal 5' exon region. Finally, by applying the target-site recognition rules, we show that the L1.LtrB intron can be modified to insert at new sites in a plasmid-borne thyA gene in Escherichia coli. This strategy should be generally applicable to retargeting group II introns and to delivering foreign sequences to specific sites in heterologous genomes.
COMT Val158Met and 5-HT1A-R -1019 C/G polymorphisms: effects on the negative symptom response to clozapine.

AIM Clozapine is still considered the gold standard for treatment-resistant schizophrenia patients; however, up to 40% of patients do not respond adequately. Identifying potential predictors of clinical response to this last-line antipsychotic could represent an important goal for treatment. Among these, functional polymorphisms involved in dopamine system modulation, known to be disrupted in schizophrenia, may play a role. We examined the COMT Val158Met polymorphism, which plays a key role in dopamine regulation at the prefrontal level, and the 5-HT1A-R -1019 C/G polymorphism, a target of clozapine activity involved in the interaction between the serotonin and dopamine systems. MATERIALS & METHODS 107 neuroleptic-refractory, biologically unrelated Italian patients (70 males and 37 females) with a DSM-IV diagnosis of schizophrenia who were being treated with clozapine were recruited. Psychopathology was assessed by the Positive and Negative Symptoms Scale (PANSS) at the beginning of treatment, and at weeks 8 and 12. Genomic DNA was extracted from venous blood samples. COMT rs4680 (Val158Met) and 5-HT1A-R rs6295 (-1019 C/G) polymorphisms were analyzed by PCR-based restriction fragment length and direct sequencing, respectively. RESULTS We found a significant effect of COMT and 5-HT1A-R on the PANSS Negative Subscale variation, with greater improvement among COMT Val/Val and 5-HT1A-R G/G subjects. CONCLUSION The findings support the hypothesis that COMT rs4680 and 5-HT1A-R rs6295 polymorphisms could influence the negative symptom response to clozapine, probably through modulation of the dopaminergic system.
Return Decomposition and the Intertemporal CAPM

The Intertemporal CAPM (ICAPM) from Merton (1973) has had a strong impact in empirical asset pricing leading to numerous multifactor models. This paper shows that the explanatory power of the ICAPM application by Campbell and Vuolteenaho (2004) relies critically on the computation of Dimson (1979) covariances (betas). If one employs the standard factor covariances (excluding lagged factors), the two-factor ICAPM has virtually no explanatory power for the average returns of the 25 size/book-to-market portfolios. More specifically, it is the covariance with the lagged innovation in one of the state variables (the value spread) that drives the explanatory power of the model. These results are inconsistent with the central economic intuition from the ICAPM. By specifying a more general version of the ICAPM, the fit of the model improves relative to the Campbell and Vuolteenaho (2004) model.
Therapy for neurocysticercosis: a reappraisal.

Accepted approaches to therapy for the different forms of neurocysticercosis are reviewed. Therapy must be individualized according to the level of disease activity and the location of the parasite. Patients with inactive disease should receive only symptomatic treatment. In contrast, patients with parenchymal brain cysts must receive a course of anticysticercal drugs. Both albendazole and praziquantel are useful; however, recent evidence favors the former as the drug of choice for this form of the disease. Albendazole (but not praziquantel) is also effective in the treatment of giant subarachnoid cysts; such medical treatment obviates surgery in some cases. Patients with ventricular cysts may also benefit from medical therapy; however, surgery is the current approach to this type of lesion, as it is to spinal cysticercosis. Although intraocular cysts have classically been resected by surgery, a recent study indicates that albendazole is equally effective. For patients with mixed forms of neurocysticercosis, therapeutic measures related to--but not directly targeting--the disease (i.e., steroid administration for brain edema or shunt placement for hydrocephalus) should be contemplated before therapy with anticysticercal drugs is instituted.
How can sanitary infrastructures reduce child malnutrition and health inequalities? Evidence from Guatemala

With the propensity score matching method, we carried out an average benefit incidence analysis that helps disclose those who really benefited from the sanitary services in Guatemala. Specifically, we tested the role of income, maternal education and social capital on how sanitary infrastructures affect child health. Results indicated that the child health benefits from infrastructure increase (decrease) with the household's socio-economic status when the infrastructure is a complement (substitute) of the private inputs provided by the household, and that the role of the infrastructure (complement or substitute) itself depends on the household's socio-economic status. Finally, results revealed that the battle against child malnutrition and health inequalities could be improved by combining sanitary infrastructure investments with effective public promotion of maternal education, social trust, and poverty reduction.
An Investigation of Market Microstructure Impacts on Event Study Returns

The authors investigate the importance of bid-ask spread-induced biases on event date returns as exemplified by seasoned equity offerings by NYSE listed firms. They document significant negative return biases on the offering day, which explain a large portion of the negative event date returns documented in the literature. Buy-sell order flow imbalance is prominent around the offering and induces a relatively large spread bias. If order imbalances are suspected, the researcher can use returns calculated from the midpoint of the closing bid and ask quotes instead of returns calculated from closing transaction prices to avoid this return bias. Copyright 1991 by American Finance Association.
Press Coverage of Mayoral Candidates

Some research on gender bias in news coverage of political campaigns indicates that the media portray male and female candidates differently. Research to date, however, has focused only on elections to national or statewide offices, where confounding variables such as party, incumbency, and competitiveness are present. The authors resolve this problem by focusing their analysis of media campaign coverage on nonpartisan, open-seat, and competitive mayoral races. The authors' content analysis of press coverage in six mayoral elections suggests that press coverage is not biased in favor of male candidates. The authors, however, find that the presence of a woman on the ballot expands the range of issue coverage in local campaigns in ways favorable to perceived strengths of female candidates.
Effect of pollution control on corporate financial performance in a transition economy

This study analyzes the effect of pollution control on corporate financial performance in a transition economy. In particular, it assesses whether better pollution control, as measured by lower air pollutant emissions, improves or undermines financial success, as captured by accounting-based measures of financial performance, e.g. profitability. For this assessment, this study analyzes the effect of air pollution control using a panel of Czech firms for the years 1996–1998. The analytical results indicate that better pollution control neither improves nor undermines financial success. These results provide no support for the hypothesis that pollution prevention, generated by improved production processes, led to lower costs, and thus, greater profitability. Copyright © 2007 John Wiley & Sons, Ltd and ERP Environment.