Miracle-dz/UniFAR-FTUs huggingface dataset:
Very high resolution precipitation climatologies from the Tropical Rainfall Measuring Mission precipitation radar

To investigate processes related to the interaction of topography and precipitation, a tropics‐wide (±36° latitude) high resolution (0.1°) ten year (1998–2007) rainfall climatology is presented from the Tropical Rainfall Measuring Mission (TRMM) precipitation radar (PR) using algorithm 2A25 version 6 near‐surface rain. We observe a tight coupling between precipitation and topography with distinct precipitation‐topography relationships present in northwest South America and South Asia. An error model is developed by subsampling the TRMM Multi‐satellite Precipitation Analysis as sampled by the PR. The error model predicts observed sampling error as a function of resolution, rain rate and sampling frequency with an r2 of 0.82. This error model indicates that the precipitation climatology at 0.1° resolution does resolve precipitation gradients in regions with large average daily rain totals including the Andes, Western Ghats, and Himalaya.
AMP-Activated Protein Kinase (AMPK) Mediates Nutrient Regulation of Thioredoxin-Interacting Protein (TXNIP) in Pancreatic Beta-Cells

Thioredoxin-interacting protein (TXNIP) regulates critical biological processes including inflammation, stress and apoptosis. TXNIP is upregulated by glucose and is a critical mediator of hyperglycemia-induced beta-cell apoptosis in diabetes. In contrast, the saturated long-chain fatty acid palmitate, although toxic to the beta-cell, inhibits TXNIP expression. The mechanisms involved in the opposing effects of glucose and fatty acids on TXNIP expression are unknown. We found that both palmitate and oleate inhibited TXNIP in a rat beta-cell line and islets. Palmitate inhibition of TXNIP was independent of fatty acid beta-oxidation or esterification. AMP-activated protein kinase (AMPK) has an important role in cellular energy sensing and control of metabolic homeostasis; therefore we investigated its involvement in nutrient regulation of TXNIP. As expected, glucose inhibited whereas palmitate stimulated AMPK. Pharmacologic activators of AMPK mimicked fatty acids by inhibiting TXNIP. AMPK knockdown increased TXNIP expression in presence of high glucose with and without palmitate, indicating that nutrient (glucose and fatty acids) effects on TXNIP are mediated in part via modulation of AMPK activity. TXNIP is transcriptionally regulated by carbohydrate response element-binding protein (ChREBP). Palmitate inhibited glucose-stimulated ChREBP nuclear entry and recruitment to the Txnip promoter, thereby inhibiting Txnip transcription. We conclude that AMPK is an important regulator of Txnip transcription via modulation of ChREBP activity. The divergent effects of glucose and fatty acids on TXNIP expression result in part from their opposing effects on AMPK activity. In light of the important role of TXNIP in beta-cell apoptosis, its inhibition by fatty acids can be regarded as an adaptive/protective response to glucolipotoxicity. The finding that AMPK mediates nutrient regulation of TXNIP may have important implications for the pathophysiology and treatment of diabetes.
Affective Mediation of Homophobic Reactions to Homosexual Males

Abstract In a test of the assumed dissimilarity/revulsion (AD/R) model of homophobia, 58 heterosexual males who differed in homophobia participated in an acquaintanceship exercise with a male partner who self-disclosed, midway through the exercise, that his sexual orientation was homosexual or heterosexual. As predicted by the AD/R model, (1) participants high in homophobia became less emotionally invested in their self-disclosures after learning of a homosexual partner's sexual orientation, whereas those low in homophobia disclosed with more emotion over time; (2) participants high in homophobia interacting with a homosexual partner reported more negative affect stemming from the acquaintanceship exercise, evaluated their partner less favorably and indicated greater desired and actual social distancing from their partner than did participants in the remaining three conditions; and (3) the relatively negative behavioral/evaluative responses of participants high in homophobia to homosexual (but not heterosexual) partners were mediated by their affective reactions to the acquaintanceship exercise.
ANAEROBIC AND AEROBIC BACTERIOLOGY OF THE SALIVA AND GINGIVA FROM 16 CAPTIVE KOMODO DRAGONS (VARANUS KOMODOENSIS): NEW IMPLICATIONS FOR THE “BACTERIA AS VENOM” MODEL

Abstract: It has been speculated that the oral flora of the Komodo dragon (Varanus komodoensis) exerts a lethal effect on its prey; yet, scant information about their specific oral flora bacteriology, especially anaerobes, exists. Consequently, the aerobic and anaerobic oral bacteriology of 16 captive Komodo dragons (10 adults and six neonates), aged 2–17 yr for adults and 7–10 days for neonates, from three U.S. zoos were studied. Saliva and gingival samples were collected by zoo personnel, inoculated into anaerobic transport media, and delivered by courier to a reference laboratory. Samples were cultured for aerobes and anaerobes. Strains were identified by standard methods and 16S rRNA gene sequencing when required. The oral flora consisted of 39 aerobic and 21 anaerobic species, with some variation by zoo. Adult dragons grew 128 isolates, including 37 aerobic gram-negative rods (one to eight per specimen), especially Enterobacteriaceae; 50 aerobic gram-positive bacteria (two to nine per specimen), especially Staphylococcus sciuri and Enterococcus faecalis, present in eight of 10 and nine of 10 dragons, respectively; and 41 anaerobes (one to six per specimen), especially clostridia. All hatchlings grew aerobes but none grew anaerobes. No virulent species were isolated. As with other carnivores, captive Komodo oral flora is simply reflective of the gut and skin flora of their recent meals and environment and is unlikely to cause rapid fatal infection.
The Effect of Advertising Appeals in Activating Self-Construals: A Case of Bicultural Chinese Generation X Consumers

Adopting a dynamic constructivist approach to culture (Hong and Chiu 2001), this project examined the effect of advertising appeals in activating self-construals among Chinese Generation X consumers. In Study 1, the bicultural disposition of this generation was evident when its salient self-construals were found to shift toward independence or interdependence in response to individualistic versus collectivistic advertisements. Study 2 demonstrated further that this self-shifting effect emerged only among bicultural Generation X individuals. Specifically, compared to when exposed to collectivistic ads, when exposed to individualistic ads, low biculturals (low in both individualistic and collectivistic orientation measures) responded with more independent self-construals, whereas high biculturals (high in both orientation measures) responded with more interdependent self-construals. Overall, these results are consistent with the theoretical expectation about the impact of globalization on biculturalism. Moreover, the results also reveal new knowledge about the role that contemporary advertising in China plays in promoting cultural changes at the individual level.
Cell extrinsic alterations in splenic B cell maturation in Flt3-ligand knockout mice

B lymphopoiesis in bone marrow (BM) is critical for maintaining a diverse peripheral B cell pool to fight infection and establish lifelong immunity. The generation of immature B cells is reduced in Flt3‐ligand (FL‐/‐) mice leading to deficiencies in splenic B cells. Here, we sought to understand the cellular basis of the spleen B cell deficiency in FL‐/‐ mice. Significant reductions in transitional (TS) and follicular (FO) B cells were found in FL‐/‐ mice, and increased frequencies, but not absolute numbers, of marginal zone (MZ) B cells. BAFF‐R expression on splenic B cells and serum levels of B cell activating factor (BAFF) was comparable to wildtype (WT) mice. Mixed BM chimeras revealed that the reductions in TS and FO B cells were cell extrinsic. FL administration into FL‐/‐ mice restored the deficiency in TS B cells and normalized the MZ compartment. Ki67 analysis revealed a significant decrease in the proliferative capacity of TS B cells in FL‐/‐ mice. A Bcl2 transgene did not rescue TS cells in FL‐/‐ mice, uncoupling FL‐deficiency to Bcl2‐dependent survival pathways. Upregulation of CD1d expression and adoptive transfer experiments suggested MZ skewing in FL‐/‐ mice. These findings support an integral role for Flt3 signaling in peripheral B cell maturation.
OA-graphs: orientation agnostic graphs for improving the legibility of charts on horizontal displays

Horizontal displays are emerging as a standard platform for engaging participants in collaborative tasks. Little is known about how groups of people view visualizations in these collaborative settings. Several techniques have been proposed to assist, such as duplicating or reorienting the visual displays. However, when visualizations compete for pixels on the display, prior solutions do not work effectively. We first ran an experiment to identify whether orientation on horizontal displays impacts the legibility of simple visualizations such as charts. The results reveal that users are best at reading a chart when it is the right side up, taking them 20% less time to read than when it is upside down. This insight led us to develop the Orientation Agnostic Graph (OA-Graph), making use of a radial layout designed to be legible regardless of orientation. In a second experiment we found that users can read OA-Graphs better than when the graphs are upside down but less well than traditional graphs in the right side up. The design of our novel visualization, informed by radial visualization methods will assist designers in developing charts that are not easily affected by user orientation, an issue that is prevalent in collaborative table-top systems. Certain tasks such as observing relative differences can benefit from OA-Graphs.
Student Voting and Political Engagement in College: Should Higher Education Be Doing More to Promote Civic Agency?

As the nation prepares for a pivotal general election this fall, it is timely to consider what role colleges and universities should play in promoting student participation in the political process. While colleges and universities have become deeply invested over the past 20 years in promoting community service and integrating service learning into the curriculum, there continues to be considerable uncertainty about the role of promoting student involvement in the political process and in the broader arena of public work.
He who dares only wins sometimes: physiological stress and contest behaviour in Xiphophorus helleri

While many factors influence contest outcome and social dominance in animals, there is increasing interest in behavioural-physiological stress-coping styles. Causality, however, is often ambiguous; is physiological state determined by contest outcome or vice versa? Furthermore, experimental protocols may themselves induce stress responses that impact individual behaviour and, thus, potentially contest outcome. Here we test whether latency to recover from acute stress, measured both physiologically and behaviourally, predicts who initiates and who wins dyadic contests between pairs of male green swordtails (Xiphophorous helleri). In line with our predictions, animals that recovered faster (behaviourally) from disturbance created by the experimental protocol prior to meeting an opponent were more likely to initiate contests; however, they were not more likely to win and, contrary to expectations, had higher pre-contest cortisol levels than their opponents. They also showed greater physiological stress responses to the experiment as determined from the difference between pre- and post-contest cortisol levels. Moreover, stress response was independent of whether a contest escalated. In contradiction to evidence found in other taxa and fish systems, the suite of traits that we measured were not correlated in a manner that allowed classification of the animals into the usual reactive and proactive stress-coping styles. Our results suggest that coping style may play a key role in determining which individual initiates a contest, but that other factors govern contest outcome.
An age-related shift of resting-state functional connectivity of the subthalamic nucleus: a potential mechanism for compensating motor performance decline in older adults

Healthy aging is associated with decline in basic motor functioning and higher motor control. Here, we investigated age-related differences in the brain-wide functional connectivity (FC) pattern of the subthalamic nucleus (STN), which plays an important role in motor response control. As earlier studies revealed functional coupling between STN and basal ganglia, which both are known to influence the conservativeness of motor responses on a superordinate level, we tested the hypothesis that STN FC with the striatum becomes dysbalanced with age. To this end, we performed a seed-based resting-state analysis of fMRI data from 361 healthy adults (mean age: 41.8, age range: 18–85) using bilateral STN as the seed region of interest. Age was included as a covariate to identify regions showing age-related changes of FC with the STN seed. The analysis revealed positive FC of the STN with several previously described subcortical and cortical regions like the anterior cingulate and sensorimotor cortex, as well as not-yet reported regions including central and posterior insula. With increasing age, we observed reduced positive FC with caudate nucleus, thalamus, and insula as well as increased positive FC with sensorimotor cortex and putamen. Furthermore, an age-related reduction of negative FC was found with precuneus and posterior cingulate cortex. We suggest that this reduced de-coupling of brain areas involved in self-relevant but motor-unrelated cognitive processing (i.e. precuneus and posterior cingulate cortex) from the STN motor network may represent a potential mechanism behind the age-dependent decline in motor performance. At the same time, older adults appear to compensate for this decline by releasing superordinate motor control areas, in particular caudate nucleus and insula, from STN interference while increasing STN-mediated response control over lower level motor areas like sensorimotor cortex and putamen.
Kinematics of the 1991 Randa rockslides (Valais, Switzerland)

Abstract. About 22 mio m3 of rock fell from a cliff near the village of Randa (10 km north of Zermatt, Switzerland) on 18 April 1991. A second retrogressive rockslide of about 7 mio m3 followed on 9 May 1991. At present, a rock mass situated above the scarp is still slowly moving toward the valley, involving several mio m 3 of rock. A kinematic approach to study of this well-documented rockslide was made "a posteriori" in order to identify the parameters relevant to the detection of such failures involving large volumes of rock. A 3-D model of the pre-rockslide geometry is presented, and is used to interpret the geostructural, hydrogeological, and chronological data. The steepness of the cliff, the massive lithology (mainly orthogneiss), the location on a topographic ridge outcropping at the confluence between a glacial cirque and the main valley, and the existence of previous events of instability were the preexisting field conditions that affected the stability of the area. The structural cause of instability was a 30 dipping, more than 500-m-long, persistent fault, which cut the base of the rock face. Together with a steeply dipping set of persistent joints, this basal discontinuity delimited a 20- mio-m 3 rock block, with a potential sliding direction approximately parallel to the axis of the valley. To the North, the fractures delimiting the unstable mass were less persistent and separated by rock bridges; this rock volume acted as key block. This topographic and structural configuration was freed from glacier support about 15 000 years BP. The various mechanisms of degradation that led to the final loss of equilibrium required various amounts of time. During the late-and post-glacial periods, seismic activity and weathering of the orthogneiss along the fissure network due to infiltration of meteoric water, joined to reduce the mechanical resistance of the sliding surfaces and the rocks bridges. In addition, crystallisation of clay minerals due to mineralogical alteration of the fault gouge accumulated along the sliding surface, reducing its angle of internal friction, and sealing the surface against water circulation. Once this basal fracture began to act as an aquiclude, the seasonal increase of the hydraulic head in the fissures promoted hydraulic fracturing on the highly stressed edges of the key block. Acceleration of this mechanical degradation occurred during the 20-year period before the 1991 rockslides, giving rise to an increasing rockfall activity, that constituted a forewarning sign. The final triggering event corresponded to a snow-melt period with high water table, leading to fracturation around the key block. On 18 April 1991, the key block finally failed, allowing subsidiary orthogneiss blocks to slide. They fell in turn over a period of several hours. The 9 May 1991, rockslide was the first of a series of expected future retrogressive reequilibrium stages of the very fractured and decompressed paragneisses, which lie on the orthogneiss base cut by the 18 April event.
Use of Operon Fusions in Mannheimia haemolytica To Identify Environmental andcis-Acting Regulators of Leukotoxin Transcription

ABSTRACT The leukotoxin of Mannheimia haemolytica is an important virulence factor that contributes to much of the pathology observed in the lungs of animals with bovine shipping fever pneumonia. We believe that identification of factors that regulate leukotoxin expression may provide insight into M. haemolyticapathogenicity. The DNA sequence upstream of the leukotoxin operon is divergently shared by PlapT, which transcribes an arginine permease gene. The intergenic region contains several elements that are potential sites for transcriptional modulation of the promoters. We have developed plasmid-borne chloramphenicol acetyltransferase (cat) operon fusions, as well aslktC::cat chromosomal fusions, to study transcription initiation in M. haemolytica. Using these genetic tools, we have identified cis-acting sequences and environmental conditions that modulate transcription of the leukotoxin and lapT promoters. By deletion analysis, promoters were shown to rely on sequences upstream of their −10 and −35 regions for full activity. Direct repeats of the sequence TGT-N(11)-ACA and a static bend region caused by phased adenine tracts were necessary for full activation of Plkt. A computer-generated model of the promoter's structure shows how DNA bending brings the repeat sequences within close proximity to the Plkt RNA polymerase, and we hypothesize that these repeats are a binding site for an activator of leukotoxin transcription. ThelktC::cat operon fusion was also used to demonstrate that, like that of other RTX toxins, leukotoxin transcription is environmentally regulated. Roles for iron deprivation and temperature change were identified.
The Role of the Mentor in Supporting New Teachers: Associations with Self-Efficacy, Reflection, and Quality

In our study, we examined variation in mentoring aspects of an induction program for 77 novice teachers and associations with self-efficacy, reflection, and quality of student–teacher interactions. Mentors’ previous experience and full- vs. part-time status predicted novices’ perception of support, reflection, and observed student–teacher interactions. Time spent with a mentor, participation in mentor-facilitated professional development activities and the quality of mentors’ interactions with novice teachers were related to novice teachers’ perceptions of mentoring success, self-reflection, and efficacy. The data in our study add to the growing research suggesting the need to look within the mentoring experience to more fully understand the working mechanisms and important contributors to their success.
Differences in Trading and Pricing between Stock and Index Options

We find that the demand for stock options that increases exposure to the underlying is positively related to the individual investor sentiments and past market returns, whereas the demand for index options is invariant to these factors. These differences in trading patterns are also reflected in the differences in the composition of traders with different types of options---options on stocks are actively traded by individual investors, whereas trades in index options are more often motivated by the hedging demand of sophisticated investors. Consistent with a demand-based view of option pricing, the individual investor sentiments and past market returns are related to time-series variations in the slope of the implied volatility smile of stock options, but they have little impact on the prices of index options. The pricing impact is more pronounced in options with a higher concentration of unsophisticated investors and those with higher delta hedging costs. Our results provide evidence that factors not related to fundamentals also impact security prices. This paper was accepted by Brad Barber, finance.
A Reorientation of Niche Theory in Human Ecology

Symptomatic of social forces is the character of the relationship between the individual and society; study of that relationship is central to sociology, a part-whole problem shared with other social sciences. A number of sociological concepts have been developed at least in part to examine this relationship. In the past couple of decades, sociologists and other social scientists have borrowed from niche theory in biological ecology, applying niche in a number of ways. In this article, the Hutchinsonian revolution in niche theory is stressed to establish that adaptations of niche into sociological human ecology are based on misleading analogies and are derived from a failure to recognize the implications of changes in niche theory. The difficulties issue in part from “the species problem” and from unclear differentiation between niche and more established sociological concepts, particularly role and status. These differences are specified and clarified prior to a radical reorientation of niche in human ecology. The reorientation resolves the species problem, updates and reinforces ties with biological ecology, and enlarges the potential for study of the linkages between individual and society and between micro and macro in complex systems.
Policy implications of population ageing in West Africa

Purpose – The purpose of this paper is to discuss trends in demographic ageing in West Africa and asks the question of what policy challenges are posed by the increasing presence of older persons in the subregion. We explore the unique dimensions of population ageing in the subregion, including its rural‐urban and gendered distributions, the occupational history of older persons, among others with the view to identifying the health, housing, and income security implications of ageing. The paper discovers and reviews what policy initiatives are being pursued in respect of older persons and suggests ways for their improvement.Design/methodology/approach – The paper draws on the existing literature on ageing and policy in both published and grey sources, including national and international policy documents. The discussion looks at policy responses in Ghana as a case example for the West African context. Policy information pertaining to Ghana is interpreted in light of the first author's personal familiarity.