Miracle-dz/UniFAR-FTUs huggingface dataset:
Increasing intake of long-chain n-3 PUFA enhances lipoperoxidation and modulates hepatic gene expression in a dose-dependent manner

Long-chain (LC) n-3 PUFA have a broad range of biological properties that can be achieved at the gene expression level. This has been well described in liver, where LC n-3 PUFA modulate the expression of genes related to lipid metabolism. However, the complexity of biological pathway modulations and the nature of bioactive molecules are still under investigation. The present study aimed to investigate the dose–response effects of LC n-3 PUFA on the production of peroxidised metabolites, as potential bioactive molecules, and on global gene expression in liver. Hypercholesterolaemic rabbits received by daily oral administration (7 weeks) either oleic acid-rich oil or a mixture of oils providing 0·1, 0·5 or 1 % (groups 1, 2 and 3 respectively) of energy as DHA. Levels of specific peroxidised metabolites, namely 4-hydroxyhexenal (4-HHE)–protein adducts, issued from LC n-3 PUFA were measured by GC/MS/MS in liver in parallel to transcription profiling. The intake of LC n-3 PUFA increased, in a dose-dependent manner, the hepatic production of 4-HHE. At the highest dose, LC n-3 PUFA provoked an accumulation of TAG in liver, which can be directly linked to increased mRNA levels of lipoprotein hepatic receptors (LDL-receptor and VLDL-receptor). In groups 1 and 2, the mRNA levels of microsomal TAG transfer protein decreased, suggesting a possible new mechanism to reduce VLDL secretion. These modulations of genes related to lipoprotein metabolism were independent of PPARα signalling but were probably linked to the activation of the farnesol X receptor pathway by LC n-3 PUFA and/or their metabolites such as HHE.
Probabilistic reference and grounding with PRAGR for dialogues with robots

In this paper, we present a system for effective referential human–robot communication in the face of perceptual deviation using the Probabilistic Reference And GRounding mechanism PRAGR and vague feature models based on prototypes. PRAGR can handle descriptions of arbitrary complexity including spatial relations and uses flexible concept assignment in generation and resolution of referring expressions for bridging conceptual gaps in referential robot–robot or human–robot interaction. We evaluate the benefit of using vague as compared to crisp properties regarding referential success and robustness towards perspective alignment error in referential robot–robot and human–robot communication.
Br Ief Definitive Repor T

IntroductIon The actin cytoskeleton is crucial for normal immune function , and a growing number of primary immunodeficiencies are caused by mutations in actin-regulating genes (Moulding et al., 2013). Autoinflammatory diseases (AIDs) are defined as diseases predominantly of the innate immune system resulting in abnormally increased inflammation (Standing et al., 2013), and it is recognized that autoinflammation and immunodefi-ciency may coexist (Frenkel, 2014). Recently, a new AID has been described in mice (WDR1 rd/rd mouse), caused by reces-sive mutation in WDR1 (Kile et al., 2007; Kim et al., 2015), a WD40 repeat protein that interacts with cofilin to promote F-actin severing and depolymerization (Okada et al.
Towards assistive human-robot micro manipulation

We propose a robotic system for assistive humanrobot micromanipulation. Using high-speed visual feedback operating at 1 kHz, the robot tracks the workpiece held by a human operator and using this information, it aligns the workpiece to the target which is mounted to the robot's actuator. The system is able to track and compensate for errors with an accuracy of less than one micrometer. As an example application, we perform experiments on the peg-in-hole task, where the robot continuously aligns a 70 μm hole, attached to the robot, to a 50 μm peg, held by the operator, in order to facilitate insertion. The results show that the proposed system outperforms the operators performing the same task with magnified visual feedback in terms of both completion time and number of successful insertions. In addition, by using the proposed system the test subjects experienced that they were subject to significantly less mental strain compared to using magnified visual feedback.
Study of completeness of registration at the Estonian cancer registry

Every cancer registry should be able to quantify the level of completeness of registration. The current study describes a routine quality control procedure in the Estonian Cancer Registry (ECR) for assessing the completeness of registration. The registry's database was compared with the databases of the Tartu University Lung Clinic and the Maarjamõisa Hospital of the Tartu University Clinics, and active retrieval to obtain missing cancer cases diagnosed in 1998 was carried out. The overall completeness of case ascertainment based on this study was 90.8%. As a result of this procedure, 67 cases of malignant neoplasms (1.1% of the total number of incident cancer cases for 1998) and 11 cases of other reportable neoplasms were detected and recorded at the ECR. Cancers of the lung, thyroid gland and prostate were most frequently under-notified. For these sites, the number of cancer cases for 1998 for Estonia as a whole increased 2.6%, 11.8% and 2.2%, respectively. To conclude, the existence of electronic databases is a positive development, but cancer registrars still need to employ labour-intensive methods to validate diagnostic codes and to decide whether to include in the ECR cases found by active retrieval. Based on the findings of our study, which is the first one of its kind in Estonia, the completeness of cancer reporting varied by cancer site, and it appeared to be a substantial concern for several sites.
The Mechanism of Photofrin Photobleaching and Its Consequences for Photodynamic Dosimetry

Abstract— We report experimental results that support a theory of self‐sensitized singlet oxygen‐mediated bleaching of the porphyrin photosensitizer Photofrin. Microelectrode measurements of photodynamic oxygen consumption were made near the surface of individual, Photofrin‐sensitized EMT6 spheroids during laser irradiation. The progressive decrease in photochemical oxygen consumption with sustained irradiation is consistent with a theory in which bleaching occurs via self‐sensitized singlet oxygen reaction with the photosensitizer ground state. A bleaching model based solely on absorbed optical energy density is inconsistent with the data. Photobleaching has a significant effect on calculated photodynamic dose distributions in 500 pin diameter spheriods. Dose distributions corrected for the effects of bleaching produce a new estimate (12.1 ± 1.2 mM) for the threshold dose of reacting singlet oxygen in this system.
Dissection of Antibacterial and Toxic Activity of Melittin

Melittin, a naturally occurring antimicrobial peptide, exhibits strong lytic activity against both eukaryotic and prokaryotic cells. Despite a tremendous amount of work done, very little is known about the amino acid sequence, which regulates its toxic activity. With the goal of understanding the basis of toxic activity and poor cell selectivity in melittin, a leucine zipper motif has been identified. To evaluate the possible structural and functional roles of this motif, melittin and its two analogs, after substituting the heptadic leucine by alanine, were synthesized and characterized. Functional studies indicated that alanine substitution in the leucine zipper motif resulted in a drastic reduction of the hemolytic activity of melittin. However, interestingly, both the designed analogs exhibited antibacterial activity comparable to melittin. Mutations caused a significant decrease in the membrane permeability of melittin in zwitterionic but not in negatively charged lipid vesicles. Although both the analogs exhibited similar secondary structures in the presence of negatively charged lipid vesicles as melittin, they failed to adopt a significant helical structure in the presence of zwitterionic lipid vesicles. Results suggest that the substitution of heptadic leucine by alanine impaired the assembly of melittin in an aqueous environment and its localization only in zwitterionic but not in negatively charged membrane. Altogether, the results suggest the identification of a structural element in melittin, which probably plays a prominent role in regulating its toxicity but not antibacterial activity. The results indicate that cell selectivity in some antimicrobial peptides can probably be introduced by modulating their assembly in an aqueous environment.
Active visual SLAM for robotic area coverage: Theory and experiment

This paper reports on an integrated navigation algorithm for the visual simultaneous localization and mapping (SLAM) robotic area coverage problem. In the robotic area coverage problem, the goal is to explore and map a given target area within a reasonable amount of time. This goal necessitates the use of minimally redundant overlap trajectories for coverage efficiency; however, visual SLAM’s navigation estimate will inevitably drift over time in the absence of loop closures. Therefore, efficient area coverage and good SLAM navigation performance represent competing objectives. To solve this decision-making problem, we introduce perception-driven navigation, an integrated navigation algorithm that automatically balances between exploration and revisitation using a reward framework. This framework accounts for SLAM localization uncertainty, area coverage performance, and the identification of good candidate regions in the environment for visual perception. Results are shown for both a hybrid simulation and real-world demonstration of a visual SLAM system for autonomous underwater ship hull inspection.
ff ects of transcranial direct current stimulation over the supplementary motor area body weight-supported treadmill gait training in hemiparetic patients after stroke

Transcranial direct current stimulation (tDCS) is used in a variety of disorders after stroke including upper limb motor dysfunctions, hemispatial neglect, aphasia, and apraxia, and its effectiveness has been demonstrated. Although gait ability is important for daily living, there were few reports of the use of tDCS to improve balance and gait ability. The supplementary motor area (SMA) was reported to play a potentially important role in balance recovery after stroke. We aimed to investigate the effect of combined therapy body weight-supported treadmill training (BWSTT) and tDCS on gait function recovery of stroke patients. Thirty stroke inpatients participated in this study. The two BWSTT periods of 1 weeks each, with real tDCS (anode: front of Cz, cathode: inion, 1 mA, 20 min) on SMA and sham stimulation, were randomized in a double-blind crossover design. We measured the time required for the 10 m Walk Test (10MWT) and Timed Up and Go (TUG) test before and after each period. We found that the real tDCS with BWSTT significantly improved gait speed (10MWT) and applicative walking ability (TUG), compared with BWSTT + sham stimulation periods (p < 0.05). Our findings demonstrated the feasibility and efficacy of tDCS in gait training after stroke. The facilitative effects of tDCS on SMA possibly improved postural control during BWSTT. The results indicated the implications for the use of tDCS in balance and gait training rehabilitation after stroke.
Increased Phenotypic Plasticity to Climate May Have Boosted the Invasion Success of Polyploid Centaurea stoebe

Phenotypic plasticity may allow organisms to cope with altered environmental conditions as e.g. after the introduction into a new range. In particular polyploid organisms, containing more than two sets of chromosomes, may show high levels of plasticity, which could in turn increase their environmental tolerance and invasiveness. Here, we studied the role of phenotypic plasticity in the invasion of Centaurea stoebe (Asteraceae), which in the native range in Europe occurs as diploids and tetraploids, whereas in the introduced range in North America so far only tetraploids have been found. In a common garden experiment at two sites in the native range, we grew half-sibs of the three geo-cytotypes (native European diploids, European tetraploids and invasive North American tetraploids) from a representative sample of 27 populations. We measured the level and the adaptive significance of phenotypic plasticity in eco-physiological and life-history traits in response to the contrasting climatic conditions at the two study sites as well as three different soil conditions in pots, simulating the most crucial abiotic differences between the native and introduced range. European tetraploids showed increased levels of phenotypic plasticity as compared to diploids in response to the different climatic conditions in traits associated with rapid growth and fast phenological development. Moreover, we found evidence for adaptive plasticity in these traits, which suggests that increased plasticity may have contributed to the invasion success of tetraploid C. stoebe by providing an advantage under the novel climatic conditions. However, in invasive tetraploids phenotypic plasticity was similar to that of native tetraploids, indicating no evolution of increased plasticity during invasions. Our findings provide the first empirical support for increased phenotypic plasticity associated with polyploids, which may contribute to their success as invasive species in novel environments.
Molecular Pathways Molecular Pathways : Fibroblast Growth Factor Signaling : A New Therapeutic Opportunity in Cancer

The fibroblast growth factor/fibroblast growth factor receptor (FGF/FGFR) signaling axis plays an important role in normal organ, vascular, and skeletal development. Deregulation of FGFR signaling through genetic modification or overexpression of the receptors (or their ligands) has been observed in numerous tumor settings, whereas the FGF/FGFR axis also plays a key role in driving tumor angiogenesis. A growing body of preclinical data shows that inhibition of FGFR signaling can result in antiproliferative and/or proapoptotic effects, both in vitro and in vivo, thus confirming the validity of the FGF/FGFR axis as a potential therapeutic target. In the past, development of therapeutic approaches to target this axis has been hampered by our inability to develop FGFR-selective agents.With the advent of a number of newmodalities for selectively inhibiting FGF/FGFR signaling, we are now in a unique position to test and validate clinically the many hypotheses that have been generated preclinically. Clin Cancer Res; 18(7); 1–8. 2012 AACR.
Acute Kidney Injury in Patients with Newly Diagnosed High-Grade Hematological Malignancies: Impact on Remission and Survival

Background Optimal chemotherapy with minimal toxicity is the main determinant of complete remission in patients with newly diagnosed hematological malignancies. Acute organ dysfunctions may impair the patient’s ability to receive optimal chemotherapy. Design and Methods To compare 6-month complete remission rates in patients with and without acute kidney injury (AKI), we collected prospective data on 200 patients with newly diagnosed high-grade malignancies (non-Hodgkin lymphoma, 53.5%; acute myeloid leukemia, 29%; acute lymphoblastic leukemia, 11.5%; and Hodgkin disease, 6%). Results According to RIFLE criteria, 137 (68.5%) patients had AKI. Five causes of AKI accounted for 91.4% of cases: hypoperfusion, tumor lysis syndrome, tubular necrosis, nephrotoxic agents, and hemophagocytic lymphohistiocytosis. Half of the AKI patients received renal replacement therapy and 14.6% received suboptimal chemotherapy. AKI was associated with a lower 6-month complete remission rate (39.4% vs. 68.3%, P<0.01) and a higher mortality rate (47.4% vs. 30.2%, P<0.01) than patients without AKI. By multivariate analysis, independent determinants of 6-month complete remission were older age, poor performance status, number of organ dysfunctions, and AKI. Conclusion AKI is common in patients with newly diagnosed high-grade malignancies and is associated with lower complete remission rates and higher mortality.
The Course and Impact of Poststroke Insomnia in Stroke Survivors Aged 18 to 65 Years: Results from the Psychosocial Outcomes In StrokE (POISE) Study

Background: Insomnia symptoms are common in the population and have negative psychosocial and functional sequelae. There are no prospective studies of the course of such symptoms and their impact, if any, in stroke survivors. This prospective cohort study investigated insomnia after stroke in working-age adults and evaluated its impact on psychological and functional outcomes over the subsequent year. Methods: We prospectively recruited 441 young (<65 years) consecutive stroke survivors from 20 public hospitals in the New South Wales Stroke Service network. Participants were assessed by self-report and interview at 28 days, 6 months, and 12 months after stroke. Insomnia was defined using a common epidemiological measure of sleep disturbance and daytime consequences. Depression, anxiety, disability, and return to work were assessed through standardized measures. Results: The point prevalence of insomnia at each time point in the year after stroke was stable at 30–37% and more common in females. Fifty-eight (16%) of all participants reported “chronic” insomnia, with symptoms at both baseline and 6 months later. At 12 months, this group was more likely to be depressed (OR 6.75, 95% CI 2.78–16.4), anxious (OR 3.31, 95% CI 1.54–7.09), disabled (OR 3.60, 95% CI 2.07–6.25), and not have returned to work, compared to those without insomnia over the same period. Conclusions: Chronic insomnia has a negative effect on disability and return to work 1 year after stroke even after adjusting for demographic, psychiatric, and disability factors. Identifying and appropriately targeting insomnia through known effective treatments may improve functional outcomes after stroke.
Practical Reasoning for Very Expressive Description Logics

Description Logics (DLs) are a family of knowledge representation formalisms mainly characterised by constructors to build complex concepts and roles from atomic ones. Expressive role constructors are important in many applications, but can be computationally problematical. We present an algorithm that decides satisfiability of the DL ALC extended with transitive and inverse roles and functional restrictions with respect to general concept inclusion axioms and role hierarchies; early experiments indicate that this algorithm is well-suited for implementation. Additionally, we show that ALC extended with just transitive and inverse roles is still in PSPACE. We investigate the limits of decidability for this family of DLs, showing that relaxing the constraints placed on the kinds of roles used in number restrictions leads to the undecidability of all inference problems. Finally, we describe a number of optimisation techniques that are crucial in obtaining implementations of the decision procedures, which, despite the worst-case complexity of the problem, exhibit good performance with real-life problems.
High point walking for health: creating built and social environments that support walking in a public housing community.

OBJECTIVES We implemented and evaluated multiple interventions to increase walking activity at a multicultural public housing site. METHODS A community-based participatory research partnership and community action teams assessed assets and barriers related to walking and developed multiple interventions to promote walking activity. Interventions included sponsoring walking groups, improving walking routes, providing information about walking options, and advocating for pedestrian safety. A pre-post study design was used to assess the changes in walking activity. RESULTS Self-reported walking activity increased among walking group participants from 65 to 109 minutes per day (P = .001). The proportion that reported being at least moderately active for at least 150 minutes per week increased from 62% to 81% (P = .018). CONCLUSIONS A multicomponent intervention developed through participatory research methods that emphasized walking groups and included additional strategies to change the built and social environments increased walking activity at a public housing site in Seattle.
A Markov Decision Process-based service migration procedure for follow me cloud

The Follow-Me Cloud (FMC) concept enables service mobility across federated data centers (DCs). Following the mobility of a mobile user, the service located in a given DC is migrated each time an optimal DC is detected. The detailed criterion for optimality is defined by operator policy, but it may be typically derived from geographical proximity or load. Service migration may be an expensive operation given the incurred cost in terms of signaling messages and data transferred between DCs. Decision on service migration defines therefore a tradeoff between cost and user perceived quality. In this paper, we address this tradeoff by modeling the service migration procedure using a Markov Decision Process (MDP). The aim is to formulate a decision policy that determines whether to migrate a service or not when the concerned User Equipment (UE) is at a certain distance from the source DC. We numerically formulate the decision policies and compare the proposed approach against the baseline counterpart.
Profiling-as-a-Service in Multi-tenant Cloud Computing Environments

Cloud computing integrates data, applications, users and servers on a vast scale and enables a global optimization of computing resources. However, due to security threats from both outside and inside the cloud, security remains as a significant challenge and obstacle in the wide adoptions of cloud computing paradigms. To enhance the security of networks, applications and data in the cloud, this position paper proposes to develop a profiling-as-a-service architecture to characterize, understand and profile network traffic at multiple layers in the multi-tenant cloud computing environment: network routers, hyper visors, virtual instances and applications. The proposed architecture will not only provide an in-depth understanding on traffic patterns of cloud tenants, but also enhance the security of cloud computing by collaboratively detecting and filtering unwanted traffic towards cloud instances.
Simultaneous Search

We introduce and solve a new class of "downward-recursive" static portfolio choice problems. An individual simultaneously chooses among ranked stochastic options, and each choice is costly. In the motivational application, just one may be exercised from those that succeed. This often emerges in practice, such as when a student applies to many colleges. We show that a greedy algorithm finds the optimal set. The optimal choices are "less aggressive" than the sequentially optimal ones, but "more aggressive" than the best singletons. The optimal set in general contains gaps. We provide a comparative static on the chosen set.