Miracle-dz/UniFAR-FTUs huggingface dataset:
Prognostic Implication of Dual-Phase PET in Adenocarcinoma of the Lung

The purpose of this study was to determine whether dual-phase 18F-FDG PET could be a prognostic factor for adenocarcinoma of the lung. Methods: One hundred patients with histologically proven adenocarcinoma of the lung were included in this retrospective analysis. All patients underwent dual-phase pretherapy 18F-FDG PET for which, after the intravenous administration of 18F-FDG, both early (∼60 min) and delayed (∼90 min) PET were acquired. The percentage change in the maximal standardized uptake values (SUVmax) of the cancer between the early and the delayed images was calculated. Overall survival of the SUVmax change over time together with the known prognostic factors were calculated by the Kaplan–Meier method and evaluated with the log-rank test. The prognostic significance was assessed by univariate and multivariate analyses. Results: Statistical analysis showed that SUVmax change over time between the early and the delayed PET was a strong independent predictor of outcome for lung adenocarcinoma. A cutoff of 25% change for SUVmax over time showed the best discriminative value. Patients with more than 25% increase in SUVmax had a median survival of 15 mo, compared with 39 mo for those with less than 25% increase in SUVmax. Conclusion: Dual-phase 18F-FDG PET reflects the dynamics of glucose metabolism. Our findings suggest that the percentage SUVmax change over time is a strong prognostic factor in patients with lung adenocarcinoma and can be complementary to the other well-known factors.
Response of the Ubiquitous Pelagic Diatom Thalassiosira weissflogii to Darkness and Anoxia

Thalassiosira weissflogii, an abundant, nitrate-storing, bloom-forming diatom in the world’s oceans, can use its intracellular nitrate pool for dissimilatory nitrate reduction to ammonium (DNRA) after sudden shifts to darkness and anoxia, most likely as a survival mechanism. T. weissflogii cells that stored 4 mM 15N-nitrate consumed 1.15 (±0.25) fmol NO3 - cell-1 h-1 and simultaneously produced 1.57 (±0.21) fmol 15NH4 + cell-1 h-1 during the first 2 hours of dark/anoxic conditions. Ammonium produced from intracellular nitrate was excreted by the cells, indicating a dissimilatory rather than assimilatory pathway. Nitrite and the greenhouse gas nitrous oxide were produced at rates 2-3 orders of magnitude lower than the ammonium production rate. While DNRA activity was restricted to the first few hours of darkness and anoxia, the subsequent degradation of photopigments took weeks to months, supporting the earlier finding that diatoms resume photosynthesis even after extended exposure to darkness and anoxia. Considering the high global abundance of T. weissflogii, its production of ammonium and nitrous oxide might be of ecological importance for oceanic oxygen minimum zones and the atmosphere, respectively.
Effects of Personal and Group Relative Deprivation on Personal and Collective Self-Esteem

The theory of relative deprivation (RD) distinguishes between personal and group RD, and links the two to personal and group identity. Models linking RD and identity suggest that identity causally precedes RD. These models are extended in the present study to allow for causal effects of RD on personal and group esteem. An experiment is reported which was designed to examine the causal effects of personal and group RD on personal self-esteem and collective self-esteem. It was predicted that experiencing personal RD would lower personal self-esteem but would not affect collective self-esteem, and, conversely, that experiencing group RD would lower collective self-esteem but would not affect personal self-esteem. The results of a 2 (sex of subject) X 2 (sex of others in group: either 3 males or 3 females) X 2 (reward condition: fair or unfair) experiment supported this prediction for personal self-esteem, but only partially supported the prediction for collective self-esteem. The implications of the results for understanding the failure of RD to translate into action, and the usefulness of the experimental paradigm for inducing personal or group RD are briefly discussed.
Comparison of effectiveness of curcumin with triamcinolone acetonide in the gel form in treatment of minor recurrent aphthous stomatitis: A randomized clinical trial.

Introduction: Recurrent aphthous stomatitis (RAS) is an unfortunately most common disease occurring in oral cavity. Although the lesion is usually self-limited, its painful presentation, high frequency of occurrence, and multifactorial etiology leads to significant morbidity. So, an efficient therapeutic strategy is needed to provide relief to the patients. Aim: To assess and compare the efficacy of Curcumin with Triamcinolone acetonide in the gel form in treatment of minor RAS. Materials and Methods: As a randomized clinical trial, 60 patients of either sex with clinically diagnosed RAS were randomly divided into 2 groups-Curcumin gel group (Group I) and Triamcinolone Acetonide gel group (Group II). Patients in either group were asked to apply the gel three times a day on each ulcer. Assessment of efficacy of gel was done on the basis of time required for regression in pain, size, and number of the ulcers. Results: The results showed significant difference in size, pain, number, and duration of ulcers in Group I and Group II within a period of 7 days. However, no significant difference was noted in both the groups in the treatment of RAS. To evaluate the efficacy, Mann-Whitney U test was used and statistical analysis was done using Statistical Package for the Social Sciences (SPSS) 19 software. Conclusion: Curcumin has strong antioxidant, with anti-inflammatory, immunomodulatory and analgesic properties, which according to the results obtained from the present study, can be used as an effective alternative to steroids in treatment of RAS.
Comparison of simian immunodeficiency virus and human immunodeficiency virus encephalitides in the immature host

The simian immunodeficiency virus (SIV) is closely related to the human immunodeficiency virus (HIV) in genomic organization and morphology. More important, SIV and HIV are both primate lentiviruses that cause transmissible immunodeficiency and encephalitis, with an apparently increased virulence in the immature host. The neuropathological features in common between SIV encephalitis in juvenile macaque monkeys and HIV encephalitis in children include the invasion of brain with virus‐laden macrophages, the formation of multinucleated (syncytial) giant cells, and white matter lesions and subtle white matter astrocytosis. Important differences include giant cell leptomeningitis and evidence of necrosis and karyorrhexis in brain macrophage infiltrates in SIV‐infected monkeys. These changes probably represent a more acute inflammatory process. The importance of future studies to define pathogenetic features of SIV encephalitis, using molecularly characterized isolates with varying neurovirulence and host range, are emphasized.
Social Identities in an International Joint Venture: An Exploratory Case Study

International joint venture (IJV) research largely omits social and cognitive processes and, hence, overlooks their potentially important implications. This paper presents a four-year longitudinal investigation into the social identification and social enactment processes in a British-Italian, shared management joint venture. Using social identification and social enactment theories as conceptual anchors, the study reveals that national social identities were the dominant sense-making vehicle used by team members, although multiple sources of social identification were possible and present in this IJV. Contextual changes occurred that could be expected to favor organizational (IJV-based) social identities, but the dominant use of nationality-based identities did not change. Our findings suggest that social identity enactments (using particular boundaries to define primary social identities) by team members mediate the relationship of contextual variables, both environmental and structural, with group and organizational outcomes (such as role investment and job satisfaction). Our empirical results shed light on unresolved debates in the IJV literature, e.g., the implications of cultural distance and shared management for IJV performance. This study also contributes to social identity theory by highlighting promising directions for development of contextual and longitudinal dimensions in that research stream.
Brain MRI with laser‐polarized 129xe

The feasibility of brain MRI with laser‐polarized 129Xe in a small animal model is demonstrated. Naturally abundant 129Xe is polarized and introduced into the lungs of Sprague‐Dawley rats. Polarized xenon gas dissolves in the blood and is transported to the brain where it accumulates in brain tissue. Spectroscopic studies reveal a single, dominant, tissue‐phase NMR resonance in the head at 194.5 ppm relative to the gas phase resonance. Images of 129Xe in the rat head were obtained with 98‐μl voxels by 2D chemical shift imaging and show that xenon is localized to the brain. This work establishes that nuclear polarization produced in the gas phases survives transport to the brain where it may be imaged. Increases in polarization and delivered volume of 129Xe will allow clinical measurements of regional cerebral blood flow.
Possible adverse drug events leading to hospital admission in a Brazilian teaching hospital

OBJECTIVES: Drug safety problems can lead to hospital admission. In Brazil, the prevalence of hospitalization due to adverse drug events is unknown. This study aims to estimate the prevalence of hospitalization due to adverse drug events and to identify the drugs, the adverse drug events, and the risk factors associated with hospital admissions. METHOD: A cross-sectional study was performed in the internal medicine ward of a teaching hospital in São Paulo State, Brazil, from August to December 2008. All patients aged ≥18 years with a length of stay ≥24 hours were interviewed about the drugs used prior to hospital admission and their symptoms/complaints/causes of hospitalization. RESULTS: In total, 248 patients were considered eligible. The prevalence of hospitalization due to potential adverse drug events in the ward was 46.4%. Overprescribed drugs and those indicated for prophylactic treatments were frequently associated with possible adverse drug events. Frequently reported symptoms were breathlessness (15.2%), fatigue (12.3%), and chest pain (9.0%). Polypharmacy was a risk factor for the occurrence of possible adverse drug events. CONCLUSION: Possible adverse drug events led to hospitalization in a high-complexity hospital, mainly in polymedicated patients. The clinical outcomes of adverse drug events are nonspecific, which delays treatment, hinders causality analysis, and contributes to the underreporting of cases.
Heavy metals in the vegetables collected from production sites.

BACKGROUND Contamination of vegetable crops (as an important part of people's diet) with heavy metals is a health concern. Therefore, monitoring levels of heavy metals in vegetables can provide useful information for promoting food safety. The present study was carried out in north-west of Iran (Tabriz) on the content of heavy metals in vegetable crops. METHODS Samples of vegetables including kurrat (n=20) (Allium ampeloprasumssp. Persicum), onion (n=20) (Allium cepa) and tomato (n=18) (Lycopersiconesculentum var. esculentum), were collected from production sites in west of Tabriz and analyzed for presence of Cd, Cr, Cu, Ni, Pb and Zn by atomic absorption spectroscopy (AAS) after extraction by aqua regia method (drying, grounding and acid diges-tion). RESULTS Mean ± SD (mg/kg DW) concentrations of Cd, Cu, Cr, Ni and Zn were 0.32 ± 0.58, 28.86 ± 28.79, 1.75 ± 2.05, 6.37± 5.61 and 58.01 ± 27.45, respec-tively. Cr, Cu and Zn were present in all the samples and the highest concentra-tions were observed in kurrat (leek). Levels of Cd, Cr and Cu were higher than the acceptable limits. There was significant difference in levels of Cr (P<0.05) and Zn (P<0.001) among the studied vegetables. Positive correlation was observed be-tween Cd:Cu (R=0.659, P<0.001) Cr:Ni (R=0.326, P<0.05) and Cr:Zn (R=0.308, P<0.05). CONCLUSION Level of heavy metals in some of the analyzed vegetables, especially kurrat samples, was higher than the standard levels. Considering the possi-ble health outcomes due to the consumption of contaminated vegetables, it is re-quired to take proper actions for avoiding people's chronic exposure.
Self-Regulatory Processes Employed During Self-Modeling: A Qualitative Analysis

Self-modeling involves the observation of oneself on an edited videotape to show a desired performance (Dowrick & Dove, 1980). While research has investigated the effects of self-modeling on physical performance and psychological mechanisms in relation to skill acquisition (e.g., Clark & Ste-Marie, 2007), no research to date has used a qualitative approach to examine the thought processes athletes engage in during the viewing of a self-modeling video in a competitive sport environment. The purpose of this study was to explore the self-regulatory processes of ten divers who viewed a self-modeling video during competitions. After competition, the divers were asked four questions relating to the self-modeling video. Zimmerman’s (2000) self-regulation framework was adopted for deductive analysis of the responses to those questions. The results indicated that a number of self-regulatory processes were employed, and they were mainly those in the forethought (75%) and self-reflection (25%) phases of Zimmerman’s model. Directions for future research in self-regulation and self-modeling are discussed. Modeling has been defined as a process where a learner observes a model dem
Comparison between HF radar current data and moored ADCP currentmeter

A preliminary assessment of accuracy of a two-sites shore-based HF Radar network along the Venice Lagoon littoral was attempted by means of comparison with a 57.5 day-long ADCP current time series for the period September-October 2002. Results showed that radar measurements were accurate (< 7 cm/s) in more than 50% of the times, since more than 50% of the differences between both E-W (U) and N-S (V) components were under 7 cm/s, and more than 50% of the direction differences were under 35 degrees. The main differences between the HF radar and surface ADCP currents can be explained in terms of random errors affecting the measurement technique and the daily sea breeze forcing, since low-pass filtering of current time series significantly improved the correlation and decreased the RMS of the differences between the two measured data set. Comparison of the semidurnal (M2, S2) tidal band suggested good agreement between tidal ellipse amplitudes. Wind forcing on a daily time-scale (sea-breeze) was associated with larger differences between radar and ADCP currents at a diurnal band due to the presence of a vertical shear in the surface layer.
Changes in Chromatin Structure in NIH 3T3 Cells Induced by Valproic Acid and Trichostatin A

Valproic acid (VPA) and trichostatin A (TSA) are known histone deacetylase inhibitors (HDACIs) with epigenetic activity that affect chromatin supra‐organization, nuclear architecture, and cellular proliferation, particularly in tumor cells. In this study, chromatin remodeling with effects extending to heterochromatic areas was investigated by image analysis in non‐transformed NIH 3T3 cells treated for different periods with different doses of VPA and TSA under conditions that indicated no loss of cell viability. Image analysis revealed chromatin decondensation that affected not only euchromatin but also heterochromatin, concomitant with a decreased activity of histone deacetylases and a general increase in histone H3 acetylation. Heterochromatin protein 1‐α (HP1‐α), identified immunocytochemically, was depleted from the pericentromeric heterochromatin following exposure to both HDACIs. Drastic changes affecting cell proliferation and micronucleation but not alteration in CCND2 expression and in ratios of Bcl‐2/Bax expression and cell death occurred following a 48‐h exposure of the NIH 3T3 cells particularly in response to higher doses of VPA. Our results demonstrated that even low doses of VPA (0.05 mM) and TSA (10 ng/ml) treatments for 1 h can affect chromatin structure, including that of the heterochromatin areas, in non‐transformed cells. HP1‐α depletion, probably related to histone demethylation at H3K9me3, in addition to the effect of VPA and TSA on histone H3 acetylation, is induced on NIH 3T3 cells. Despite these facts, alterations in cell proliferation and micronucleation, possibly depending on mitotic spindle defects, require a longer exposure to higher doses of VPA and TSA. J. Cell. Biochem. 115: 1937–1947, 2014. © 2014 Wiley Periodicals, Inc.
The Multidimensional Assessment of Interoceptive Awareness (MAIA)

This paper describes the development of a multidimensional self-report measure of interoceptive body awareness. The systematic mixed-methods process involved reviewing the current literature, specifying a multidimensional conceptual framework, evaluating prior instruments, developing items, and analyzing focus group responses to scale items by instructors and patients of body awareness-enhancing therapies. Following refinement by cognitive testing, items were field-tested in students and instructors of mind-body approaches. Final item selection was achieved by submitting the field test data to an iterative process using multiple validation methods, including exploratory cluster and confirmatory factor analyses, comparison between known groups, and correlations with established measures of related constructs. The resulting 32-item multidimensional instrument assesses eight concepts. The psychometric properties of these final scales suggest that the Multidimensional Assessment of Interoceptive Awareness (MAIA) may serve as a starting point for research and further collaborative refinement.
Pilot Your Life Decisively for Well-Being and Flourishing

I have been a pilot, aviation instructor and FAA Pilot Examiner for over 40 years. Aviation requires a “pilot in command” mindset consistent with the tenets of positive psychology. This paper explains and advocates for this daily empowered, adaptive decision making process used by pilots in aviation as a necessary life skill to eliminate mind wandering and disengagement and optimize human performance consistent with the goals of positive psychology. Exploring the concepts of “pilot-in-command” (decisive control and self-efficacy) and “situational awareness” (alert mental functioning) I will offer techniques and suggestions for developing and deploying these critical skills in everyday life. I will examine the heuristic-based, “fast and frugal” (time and data limited) decision-making used every day in aviation and apply this to life for optimal performance and flourishing for individual lives and organizational effectiveness.
Compositional semantics for open Petri nets based on deterministic processes

In order to model the behaviour of open concurrent systems by means of Petri nets, we introduce open Petri nets, a generalisation of the ordinary model where some places, designated as open, represent an interface between the system and the environment. Besides generalising the token game to reflect this extension, we define a truly concurrent semantics for open nets by extending the Goltz–Reisig process semantics of Petri nets. We introduce a composition operation over open nets, characterised as a pushout in the corresponding category, suitable for modelling both interaction through open places and synchronisation of transitions. The deterministic process semantics is shown to be compositional with respect to such a composition operation. If a net $Z_3$ results as the composition of two nets $Z_1$ and $Z_2$, having a common subnet $Z_0$, then any two deterministic processes of $Z_1$ and $Z_2$ that ‘agree’ on the common part, can be ‘amalgamated’ to produce a deterministic process of $Z_3$. Conversely, any deterministic process of $Z_3$ can be decomposed into processes of the component nets. The amalgamation and decomposition operations are shown to be inverse to each other, leading to a bijective correspondence between the deterministic processes of $Z_3$ and the pair of deterministic processes of $Z_1$ and $Z_2$ that agree on the common subnet $Z_0$. Technically, our result is similar to the amalgamation theorem for data-types in the framework of algebraic specification. A possible application field of the proposed constructions and results is the modelling of interorganisational workflows, recently studied in the literature. This is illustrated by a running example.
The resource based theory: dissemination and main trends

Papers published on the resource-based theory (RBT) have made clear its widespread application, heterogeneity, and usefulness as a strategic approach. This paper empirically analyzes the assumptions underlying the theory from an inductive perspective. The paper differs from previous works by identifying the main trends within the theory and by noting their diffusion among the leading management-oriented journals. Three main trends are shown to coexist within RBT: the resource-based view, the knowledge-based view, and the relational view. Copyright © 2006 John Wiley & Sons, Ltd.
Early fixation of the vertically unstable pelvis: the role of iliosacral screw fixation of the posterior lesion.

OBJECTIVES To evaluate the effectiveness of the use of iliosacral screw fixation in the management of the vertically unstable pelvis. STUDY DESIGN Retrospective analysis with clinical follow-up of patients to assess functional outcome. METHODS Thirty-eight vertically unstable pelvic fractures were treated using iliosacral screw fixation. Anterior fixation was by means of plating in sixteen pelves and by external fixation in fifteen pelves. Four pelves had no anterior fixation. Complications were recorded and radiographs were analyzed to classify fractures and identify screw misplacement and malunion. Twenty-six patients had a functional evaluation. RESULTS Five patients (13 percent) suffered a pulmonary embolus in the early postoperative period, one of which was fatal, a hospital mortality of 2.6 percent. Screw misplacement occurred in five patients but there were no adverse sequelae. In thirty-four cases with radiographic follow-up, malunion was noted in fifteen cases (44 percent). A lower rate of malunion (36 percent) was noted with internal fixation of the anterior lesion. Of twenty-six patients with long-term follow-up, only four (15 percent) had no pain. Sacroiliac fusion for pain was performed in three patients (11 percent). Twelve patients (46 percent) returned to their preinjury occupation, six patients (23 percent) changed occupation, and nine patients (30 percent) had not yet returned to work by last follow-up. CONCLUSIONS Iliosacral screw fixation is a useful method of fixation in the vertically unstable pelvis but needs to be augmented by rigid anterior fixation to minimize malunion.