Miracle-dz/UniFAR-FTUs huggingface dataset:
On the Decidability and Complexity of Some Fragments of Metric Temporal Logic

Metric Temporal Logic, $\mtlfull$ is amongst the most studied real-time logics. It exhibits considerable diversity in expressiveness and decidability properties based on the permitted set of modalities and the nature of time interval constraints $I$. \oomit{The classical results of Alur and Henzinger showed that $\mtlfull$ is undecidable where as $\mitl$ which uses only non-singular intervals $NS$ is decidable. In a surprizing result, Ouaknine and Worrell showed that the satisfiability of $\mtl$ is decidable over finite pointwise models, albeit with NPR decision complexity, whereas it remains undecidable for infinite pointwise models or for continuous time. } In this paper, we sharpen the decidability results by showing that the satisfiability of $\mtlsns$ (where $NS$ denotes non-singular intervals) is also decidable over finite pointwise strictly monotonic time. We give a satisfiability preserving reduction from the logic $\mtlsns$ to decidable logic $\mtl$ of Ouaknine and Worrell using the technique of temporal projections. We also investigate the decidability of unary fragment $\mtlfullunary$ (a question posed by A. Rabinovich) and show that $\mtlfut$ over continuous time as well as $\mtlfullunary$ over finite pointwise time are both undecidable. Moreover, $\mathsf{MTL}^{pw}[\fut_I]$ over finite pointwise models already has NPR lower bound for satisfiability checking. We also compare the expressive powers of some of these fragments using the technique of EF games for $\mathsf{MTL}$.
Cardiac Micro–Computed Tomography Imaging of the Aging Coronary Vasculature

Background— Alterations at the level of the coronary circulation with aging may play an important role in the evolution of age-associated changes in left ventricular (LV) fibrosis and function. However these age-associated changes in the coronary vasculature remain poorly defined primarily due to the lack of high resolution imaging technologies. The current study was designed to utilize cardiac micro–computed tomography (micro-CT) technology as a novel imaging strategy, to define the 3-dimensional coronary circulation in the young and aged heart and its relationship to LV fibrosis and function. Methods and Results— Young (2 months old; n=10) and aged (20 months old; n=10) Fischer rats underwent cardiac micro-CT imaging as well as echocardiography, blood pressure, and fibrosis analysis. Importantly, when indexed to LV mass, which increased with age, the total and intramyocardial vessel volumes were lower, whereas the epicardial vessel volume, with and without indexing to LV mass, was significantly higher in the aged hearts compared with the young hearts. Moreover, the aged hearts had a significantly lower percentage of intramyocardial vessel volume and a significantly higher percentage of epicardial vessel volume, when normalized to the total vessel volume, compared with the young hearts. Further, the aged hearts had significant LV fibrosis and mild LV dysfunction compared with the young hearts. Conclusions— This micro-CT imaging study reports the reduction in normalized intramyocardial vessel volume within the aged heart, in association with increased epicardial vessel volume, in the setting of increased LV fibrosis, and mild LV dysfunction.
Navigation for People with Mild Dementia

Community dwelling is a problem for people with dementia. Can GPS route navigation support on a mobile device provide a solution? In a small scale exploratory research with this target group we studied the effects of two different types of audio instructions and assessed the pedestrian safety while operating the device. Methodological issues that limited the size and scope of data collection notwithstanding, evidence of unsafe behaviour was not found. Navigation instructions spoken by a familiar voice seemed to have a positive impact on the effectiveness of the navigation system, while the use of warning sounds seemed to have the opposite effect.
On the number of distributed measurement points for network tomography

Internet topology information is only made available in aggregate form by standard routing protocols. Connectivity information and latency characteristics must therefore be inferred using indirect techniques. In this paper we consider measurements using a distributed set of measurement points or beacons. We show that computing the minimum number of required beacons on a network under a BGP-like routing policy is NP-hard and at best Ω(log n)-approximable. In the worst case at least (n-1)/3 and at most (n+1)/3 beacons are required for a network with n nodes. We then introduce some observations that allow us to propose a relatively small candidate set of beacons for the current Internet topology. The set proposed has properties with relevant applications for all-paths routing on the public Internet and performance based routing.
Liver Transplant Recipients Quality of Life Instrument: Development and Psychometric Testing

Background Liver transplantation is a life-saving intervention for many patients with end-stage liver disease. In the past, evaluation of successful liver transplantation was based on patients’ survival rate. However, in recent years this evaluation has been based on patients’ quality of life. Various instruments have been developed to evaluate patients’ quality of life. Nonetheless, scholars still believe that it is crucial to develop a standardized and disease specific instrument for evaluating the quality of life in liver transplant recipients. Objectives The aim of this paper was to describe the development and psychometric testing process of a quality of life instrument specific to liver transplant recipients. Materials and Methods Initial items of this instrument were extracted from a conventional content analysis study, and then were completed with findings of related international literature. The face validity was assessed by interviewing with four liver transplant recipients, and the content validity was evaluated by eleven experts in the field of transplantation. The construct validity was achieved by involving 250 liver transplant recipients through exploratory factor analysis method, and reliability was calculated by Cronbach's alpha. Results Three main factors with 40 items were extracted from the exploratory factor analysis: Health Satisfaction, Concerns, and Complications. Reliability of the instrument was confirmed (alpha = 0.922). Conclusions Given the special considerations regarding liver transplant recipients, this questionnaire is more accurate in evaluating the success of liver transplantation.
miR148b is a major coordinator of breast cancer progression in a relapse‐associated microRNA signature by targeting ITGA5, ROCK1, PIK3CA, NRAS, and CSF1

Breast cancer is often fatal during its metastatic dissemination. To unravel the role of microRNAs (miRs) during malignancy, we analyzed miR expression in 77 primary breast carcinomas and identified 16 relapse‐associated miRs that correlate with survival and/or distinguish tumor subtypes in different datasets. Among them, miR‐148b, down‐regulated in aggressive breast tumors, was found to be a major coordinator of malignancy. In fact, it is able to oppose various steps of tumor progression when overexpressed in cell lines by influencing invasion, survival to anoikis, extravasation, lung metastasis formation, and chemotherapy response. miR‐148b controls malignancy by coordinating a novel pathway involving over 130 genes and, in particular, it directly targets players of the integrin signaling, such as ITGA5, ROCK1, PIK3CA/p110α, and NRAS, as well as CSF1, a growth factor for stroma cells. Our findings reveal the importance of the identified 16 miRs for disease outcome predictions and suggest a critical role for miR‐148b in the control of breast cancer progression. —Cimino, D. , De Pittà, C. , Orso, F. , Zampini, M. , Casara, C. , Penna, E. , Quaglino, E. , Forni, M. , Damasco, C. , Pinatel, E. , Ponzone, R. , Romualdi, C. , Brisken, C. , De Bortoli, M. , Biglia, N. , Provero, P., Lanfranchi, G. , Taverna, D. miR148b is a major coordinator of breast cancer progression in a relapse‐associated microRNA signature by targeting ITGA5, ROCK1, PIK3CA, NRAS, and CSF1. FASEB J. 27, 1223–1235 (2013). www.fasebj. org
Evaluation of the Injury Impairment Scale, a Tool to Predict Road Crash Sequelae, in a French Cohort of Road Crash Survivors

Objective: The objective of the present study was to validate sequelae prediction by the Maximal Injury Impairment Score (M-IIS) in comparison with the Functional Independence Measure (FIM) assessed at 1-year follow-up of severe road crash victims. Methods: The study population came from “the Etude et Suivi d’une Population d’Accidentés de la Route dans le Rhône” (ESPARR; Rhône Area Road Crash Victim Follow-up Study) cohort: 178 victims (with Maximal Abbreviated Injury Scale ≥ 3) of road crashes in the Rhône administrative department of France, aged ≥ 16 years and with medical examination including FIM scoring 1 year postaccident. Two thresholds were tested for both scores. Firstly, the relation between FIM and M-IIS was assessed on logistic regression models adjusted on age and presence of complications at 1 year postaccident. The predictive capacity of M-IIS was expressed as its negative and positive predictive values and was considered good when 80 percent or better. Results: Sixty-three of the 178 adult subjects (mean age = 37.7 years; range = 16.1–82.9 years) showed postaccident complications. One-year sequelae prediction on M-IIS was greater in head, spine, and limb lesions but limited to slight impairments (M-IIS = 1). There was a significant correlation between FIM and M-IIS, although age and medical complications were confounding factors on certain multivariate models. The predictive capacity of M-IIS was low for all types of sequelae. Conclusions: M-IIS, in this severely injured population, failed to predict sequelae at 1 year as measured by the FIM, despite a good correlation between the two. Complications are to be taken into account in assessing the M-IIS's capacity to predict sequelae. Further evaluation will be needed on larger series or assessment of other indicators and measures of sequelae at 1 year to obtain a robust tool to predict road crash sequelae.
Semantic Frame Annotation on the French MEDIA corpus

This paper introduces a knowledge representation formalism used for annotation of the French MEDIA dialogue corpus in terms of high level semantic structures. The semantic annotation, worked out according to the Berkeley FrameNet paradigm, is incremental and partially automated. We describe an automatic interpretation process for composing semantic structures from basic semantic constituents using patterns involving words and constituents. This process contains procedures which provide semantic compositions and generating frame hypotheses by inference. The MEDIA corpus is a French dialogue corpus recorded using a Wizard of Oz system simulating a telephone server for tourist information and hotel booking. It had been manually transcribed and annotated at the word and semantic constituent levels. These levels support the automatic interpretation process which provides a high level semantic frame annotation. The Frame based Knowledge Source we composed contains Frame definitions and composition rules. We finally provide some results obtained on the automatically-derived annotation.
Overexpression of E2F3 promotes proliferation of functional human β cells without induction of apoptosis

The mechanisms that control proliferation, or lack thereof, in adult human β cells are poorly understood. Controlled induction of proliferation could dramatically expand the clinical application of islet cell transplantation and represents an important component of regenerative approaches to a functional cure of diabetes. Adult human β cells are particularly resistant to common proliferative targets and often dedifferentiate during proliferation. Here we show that expression of the transcription factor E2F3 has a role in regulating β-cell quiescence and proliferation. We found human islets have virtually no expression of the pro-proliferative G1/S transcription factors E2F1–3, but an abundance of inhibitory E2Fs 4–6. In proliferative human insulinomas, inhibitory E2Fs were absent, while E2F3 is expressed. Using this pattern as a “roadmap” for proliferation, we demonstrated that ectopic expression of nuclear E2F3 induced significant expansion of insulin-positive cells in both rat and human islets. These cells did not undergo apoptosis and retained their glucose-responsive insulin secretion, showing the ability to reverse diabetes in mice. Our results suggest that E2F4–6 may help maintain quiescence in human β cells and identify E2F3 as a novel target to induce proliferation of functional β cells. Refinement of this approach may increase the islets available for cell-based therapies and research and could provide important cues for understanding in vivo proliferation of β cells.
A Common Polymorphism near the ESR1 Gene Is Associated with Risk of Breast Cancer: Evidence from a Case-Control Study and a Meta-Analysis

Background Genome-wide association studies have reported that a polymorphism near the estrogen receptor gene (ESR1) (rs2046210) is associated with a risk of breast cancer, with the A allele conferring an increased risk. However, considering the controversial results from more recent replicated studies, we conducted a case-control study in an independent Chinese Han population and a meta-analysis to clarify the association of this polymorphism with breast cancer risk. Method and Findings A hospital-based case-control study including 461 cases and 537 controls from a Chinese Han population was conducted initially, and this study showed that the rs2046210 A allele was significantly associated with breast cancer risk, with an OR of 1.32 (95% CI = 1.10–1.59). Subsequently, a meta-analysis integrating the current study and previous publications with a total of 53,379 cases and 55,493 controls was performed to further confirm our findings. Similarly, a significant association between this polymorphism and breast cancer risk was also observed in the overall population especially among Asians, with ORs for per A allele of 1.14 (95% CI = 1.10–1.18) in the overall population and 1.27 (95% CI = 1.23–1.31) in the Asian population. Conclusion Our results provide strong evidence to support that the common polymorphism near the ESR1 gene, rs2046210, is associated with an increased risk of breast cancer in Asian and European populations but not in Africans, although the biological mechanisms need to be further investigated.
What Do Premiums Paid for Bank M&As Reflect? The Case of the European Union

We analyze the takeover premiums paid for a sample of European bank mergers between 1997 and 2007. We find that acquiring banks value profitable, high-growth and low risk targets. We also find that the strength of bank regulation and supervision as well as deposit insurance regimes in Europe have measurable effects on takeover pricing. Stricter bank regulatory regimes and stronger deposit insurance schemes lower the takeover premiums paid by acquiring banks. This result, presumably in anticipation of higher compliance costs, is mainly driven by domestic deals. Also, we find no conclusive evidence that bidders seek to extract benefits from regulators either by paying a premium for deals in less regulated regimes or by becoming "too big to fail".
Rate of elimination of homologous globulins (including antibody) from the circulation.

Schoenheimer, Ratner, Rittenberg & Heidelberger (1942) and Heidelberger, Treffers, Schoenheimer, Ratner & Rittenberg (1942) showed that pneumococcus antibodies are synthesized and eliminated from the circulation in actively immunized rabbits in much the same way as other 15N-labelled plasma proteins, and also that antibodies passively transfused to a non-immune animal do not incorporate 15N administered as glycine in the diet. They arrived at a half-life for antibody and normal plasma proteins of 20 days, which is much longer than the values later obtained for rabbit plasma proteins by the use of 14C-labelled amino acids (cf. review by McFarlane, 1952). It is probable that the discrepancy is due to repeated utilization of labelled amino nitrogen. We thought it worth while, therefore, to repeat their work both on actively and passively immunized rabbits, but using [14C]lysine and [14C]phenylalanine instead of glycine. It seemed to us particularly important to investigate whether passively transfused antibody takes up amino acid carbon. If antibody molecules take up neither nitrogen nor carbon from free amino acids, we may assume that they are not subject in the circulation to chemical reactions affecting their amino acid composition, and by analogy that normal plasma-protein molecules also enjoy the
Fabrication of a Photonic Crystal using self-assembly : A potentially new rear reflector for thin solar cells

The major issue with solar cells today, is the price per watt. To tackle this challenge several approaches are being made. One possible approach is to reduce the amount of silicon raw material used in todays wafer-based solar cells by making the wafers thinner. This approach does however bring with it another problem; much of the incident light will escape the cell before being absorbed. One possible way to solve this problem is to use a photonic crystal (PC) as a rear reflector. PCs is a periodic dielectric structure that can reflect light in a non-specular manner, which can substantially increase the optical pathlength for the light within the cell, and hence increase the probability of absorption- One such PC is the inverted opal. To make an inverted opal, one first fabricates a synthetic opal, consisting of microspheres of some kind, that can be used as a template. The gaps between the spheres of such an opal can then be filled with a suitable dielectric, e.g. silicon, and the spheres can be removed by a selective process, leaving the inverted opal structure. In this master project, opals were attempted made with Ugelstad spheres and polysterene (PS) spheres. With the Ugelstad spheres, wafer sized monolayers were made, but opals were not achieved. The PS spheres however, proved very suitable, and opals with a grain size of 150x300$mu m$ were successfully made. These opals were then partially inverted, by first filling in the gaps between the spheres with silicon, using a low temperature low pressure PECVD process, and then heating the samples to 600 degrees Celsius for 2.5 hours.
Comprehensive Analysis of Sequential and Combinational Soft Errors in an Embedded Processor

Radiation-induced soft errors have become a key challenge in advanced commercial electronic components and systems. We present the results of a soft error rate (SER) analysis of an embedded processor. Our SER analysis platform accurately models generation, propagation, and masking effects starting from a technology response model derived using TCAD simulations at the device level all the way to application masking. The platform employs a combination of accurate models at the device level, analytical error propagation at gate level, and fault emulation at the architecture/application level to provide the detailed contribution of each component (flip-flops, combinational gates, and SRAMs) to the overall SER. At each stage in the modeling hierarchy, an appropriate level of abstraction is used to propagate the effect of errors to the next higher level. Unlike previous studies which are based on very simple test chips, analyzing the entire processor gives more insight into the relative contributions of combinational and sequential SER. The results of this analysis can assist circuit designers to adopt effective hardening techniques to reduce the overall SER while meeting the required power and performance constraints.
Web-Based Newborn Screening System for Metabolic Diseases: Machine Learning Versus Clinicians

The metabolic disorders may hinder an infant's normal physical or mental development during the neonatal period. The metabolic diseases can be treated by effective therapies if the diseases are discovered in the early stages. Therefore, newborn screening program is essential to prevent neonatal from these damages. In the paper, a support vector machine (SVM) based algorithm is introduced in place of cut-off value decision to evaluate the analyte elevation raw data associated with Phenylketonuria. The data were obtained from tandem mass spectrometry (MS/MS) for newborns. In addition, a combined feature selection mechanism is proposed to compare with the cut-off scheme. By adapting the mechanism, the number of suspected cases is reduced substantially, it also handles the medical resources effectively and efficiently.
Secondary metabolites from Aspergillus japonicus CAM231, an endophytic fungus associated with Garcinia preussii

Abstract Chemical investigation of Aspergillus japonicus CAM231, isolated from the leaf of Garcina preussii collected in Cameroon, yielded two new compounds; one pyrone derivative, hydroxy neovasinin (1) and one phenol derivative, asperolan (2), together with two known compounds neovasifurarone B (3) and variecolin (4). The structures of the two new compounds were established using intensive NMR spectroscopy and HRMS spectra in comparison with data found in literature. The structure of compound 1 was confirmed by single-crystal X-ray crystallographic analysis in combination with NOESY experiment. The new compounds were screened for their cytotoxic and antibacterial properties; however, the tested compounds displayed no significant activities.
Evaluation of fine‐needle aspiration cytology for renal masses

Objective To evaluate the accuracy and use of fine‐needle aspiration (FNA) cytology for the diagnosis of renal masses because with the improved quality and increasing use of ultrasonography and computed tomography (CT), asymptomatic renal masses, par‐ticularly small (< 5 cm) tumours, are being discovered more frequently.
The Instrument-Rate Projection under Inflation Targeting: The Norwegian Example

The introduction of inflation targeting has led to major progress in practical monetary policy. Recent debate has focused on the interest-rate assumption underlying published projections of inflation and other target variables. This paper discusses the role of alternative interest-rate paths in the monetary-policy decision process and the recent publication by Norges Bank (the central bank of Norway) of optimal interest-rate projections with fan charts.
Spectral thresholds in the bipartite stochastic block model

We consider a bipartite stochastic block model on vertex sets $V_1$ and $V_2$, with planted partitions in each, and ask at what densities efficient algorithms can recover the partition of the smaller vertex set. When $|V_2| \gg |V_1|$, multiple thresholds emerge. We first locate a sharp threshold for detection of the partition, in the sense of the results of \cite{mossel2012stochastic,mossel2013proof} and \cite{massoulie2014community} for the stochastic block model. We then show that at a higher edge density, the singular vectors of the rectangular biadjacency matrix exhibit a localization / delocalization phase transition, giving recovery above the threshold and no recovery below. Nevertheless, we propose a simple spectral algorithm, Diagonal Deletion SVD, which recovers the partition at a nearly optimal edge density. The bipartite stochastic block model studied here was used by \cite{feldman2014algorithm} to give a unified algorithm for recovering planted partitions and assignments in random hypergraphs and random $k$-SAT formulae respectively. Our results give the best known bounds for the clause density at which solutions can be found efficiently in these models as well as showing a barrier to further improvement via this reduction to the bipartite block model.