Miracle-dz/UniFAR-FTUs huggingface dataset:
A model for light‐limited continuous cultures: Growth, shading, and maintenance

Light‐limited growth in continuous cultures of phototrophic organisms is modeled. It is assumed that light energy up‐take rate depends hyperbolically on light intensity and that the maintenance costs are proportional to biomass. Modeling the light distribution caused by shading within the vessel is necessary to explain the existence of steady state in light‐limited chemostats. The model fits well to experimental data from literature on light‐limited chemostats and turbidostats. Attention is given to the implications of the model for the estimation of the specific maintenance rate constant in light‐limited continuous cultures.
Dynamic Programming for Linear-Time Incremental Parsing

Incremental parsing techniques such as shift-reduce have gained popularity thanks to their efficiency, but there remains a major problem: the search is greedy and only explores a tiny fraction of the whole space (even with beam search) as opposed to dynamic programming. We show that, surprisingly, dynamic programming is in fact possible for many shift-reduce parsers, by merging "equivalent" stacks based on feature values. Empirically, our algorithm yields up to a five-fold speedup over a state-of-the-art shift-reduce dependency parser with no loss in accuracy. Better search also leads to better learning, and our final parser outperforms all previously reported dependency parsers for English and Chinese, yet is much faster.
N- and O-Glycosylation in the Murine Synaptosome*

We present the first large scale study characterizing both N- and O-linked glycosylation in a site-specific manner on hundreds of proteins. We demonstrate that a lectin-affinity fractionation step using wheat germ agglutinin enriches not only peptides carrying intracellular O-GlcNAc, but also those bearing ER/Golgi-derived N- and O-linked carbohydrate structures. Liquid chromatography-MS (LC/MS) analysis with high accuracy precursor mass measurements and high sensitivity ion trap electron-transfer dissociation (ETD) were utilized for structural characterization of glycopeptides. Our results reveal both the identity of the precise sites of glycosylation and information on the oligosaccharide structures possible on these proteins. We report a novel iterative approach that allowed us to interpret the ETD data set directly without making prior assumptions about the nature and distribution of oligosaccharides present in our glycopeptide mixture. Over 2500 unique N- and O-linked glycopeptides were identified on 453 proteins. The extent of microheterogeneity varied extensively, and up to 19 different oligosaccharides were attached at a given site. We describe the presence of the well-known mucin-type structures for O-glycosylation, an EGF-domain-specific fucosylation and a rare O-mannosylation on the transmembrane phosphatase Ptprz1. Finally, we identified three examples of O-glycosylation on tyrosine residues.
Proof-Carrying Cloud Computation: The Case of Convex Optimization

Cloud computing offers a great opportunity to bridge the gap between the fast growing computation needs and limited local resources. However, without the adequate trust and strong integrity assurance, it would be difficult to expect clients to completely turn over control of their computation to the cloud. Hence, securing cloud computation becomes an imperative and challenging task, especially in the aspect of integrity verification. To address the challenge, we propose a hassle-free, fixed-rate, and job-based software as a service cloud model along with the integrity verification mechanisms, with particular focus on outsourcing the widely applicable engineering optimization problem, i.e., convex optimization. We aim to construct efficient integrity verification mechanisms using application-specific techniques. Our security design does not require the use of heavy cryptographic tools. Instead, we leverage the inherent structure of the optimization problems and make the computation outsourcing proof-carrying to achieve efficient integrity verification. The proposed design provides substantial computational savings on the client side and introduces marginal overhead on the cloud side. We further prove its correctness and soundness. The extensive experiments under the real cloud environment show our mechanisms ensure strong integrity assurance with high efficiency on both the client and the cloud sides and are readily applicable in current practice.
Growth Pattern, Nutrient use Ratio and Nutrient Harvest Index as Influenced by Nutrient Management in Pearlmillet

Pearl millet [Pennisetum glaucum (L.) R. Br. Emend. Stuntz] is one of the most extensively cultivated cereal crops in the environmental conditions with limited and erratic rainfall, high temperature and poor soil condition with low nutrient levels too harsh for other cereals crops (Renu et al., 2017). It is impossible to beat the pearl millet in growing it in the world’s hardest agricultural production environment, due to its capacity to extract mineral nutrition and water even from the poorest soils. Pearl millet grain has higher protein content (11.6%), carbohydrate (67.3%), fat (5%) and fiber (12%), higher level of iron and zinc and insoluble dietary fiber (Sinha, 2015). To meet the ever growing food demand with limited resources, we need to increase the productivity by adopting better agronomic practices and efficient fertilization. Today, it is getting more attention due to increasing evidence of less seasonal rainfall, terminal heat, frequent occurrence of extreme weather events coupled with scanty water resources (Singh et al, 2013a). The increase in crop production has been mainly resulted from the application of N-P-K fertilizers (Brady and International Journal of Current Microbiology and Applied Sciences ISSN: 2319-7706 Volume 7 Number 08 (2018) Journal homepage: http://www.ijcmas. com
Chinese Military Modernization Implications for Strategic Nuclear Arms Control

In the preparatory meetings for the 2015 Review Conference (RevCon) of the Nuclear Nonproliferation Treaty (NPT), the nuclear abolition or disarmament movement has urgently reiterated the demand that nuclear-weapon states (NWS) must live up to their Article VI commitments as defined by the 1995 and 2000 RevCons' final reports. Increasingly, this demand is predicated on a humanitarian imperative to prevent the horrific effects of nuclear war or nuclear-weapon accident. The term humanitarian imperative is the most recent expression of a long-standing moral demand by the global antinuclear movement that the human and environmental suffering resulting from nuclear war or accident constitutes a supreme moral evil and, perhaps, a supreme moral emergency The NWS have resolutely resisted this demand, in part because they fear the effects of instability and insecurity that might result from nuclear abolition. Indeed, the results from all of the NPT RevCons have demonstrated that the demand for nuclear abolition has failed to pressure the NPT NWS to act beyond strategically and politically prudent nuclear arms reductions. Moreover, some of the NPT NWS have initiated nuclear-weapons modernization projects, which indicate their sustained commitment to nuclear deterrence for the indefinite future. The current political contest between antinuclear global civil-society groups and the NPT NWS raises two focal questions. First, assuming nuclear disarmament is truly a humanitarian and moral imperative, what are the policy preconditions for effective implementation? The academic and policy literature offers a variety of answers to this question that is important to review. A second and more important question is Thomas Doyle is an assistant professor of political science at Texas State University. His research focuses on the intersection of international security and international ethics. His recently published book is titled The Ethics of Nuclear Weapons Dissemination: Moral Dilemmas of Aspiration, Avoidance, and Prevention (Routledge, 2015). STRATEGIC STUDIES QUARTERLY ♦ Summer 2015 [19]
Deletion of smn-1, the Caenorhabditis elegans ortholog of the spinal muscular atrophy gene, results in locomotor dysfunction and reduced lifespan

Spinal muscular atrophy is the most common genetic cause of infant mortality and is characterized by degeneration of lower motor neurons leading to muscle wasting. The causative gene has been identified as survival motor neuron (SMN). The invertebrate model organism Caenorhabditis elegans contains smn-1, the ortholog of human SMN. Caenorhabditis elegans smn-1 is expressed in various tissues including the nervous system and body wall muscle, and knockdown of smn-1 by RNA interference is embryonic lethal. Here we show that the smn-1(ok355) deletion, which removes most of smn-1 including the translation start site, produces a pleiotropic phenotype including late larval arrest, reduced lifespan, sterility as well as impaired locomotion and pharyngeal activity. Mutant nematodes develop to late larval stages due to maternal contribution of the smn-1 gene product that allows to study SMN-1 functions beyond embryogenesis. Neuronal, but not muscle-directed, expression of smn-1 partially rescues the smn-1(ok355) phenotype. Thus, the deletion mutant smn-1(ok355) provides a useful platform for functional analysis of an invertebrate ortholog of the human SMN protein.
Altered Sphingolipid Balance in Capillary Cerebral Amyloid Angiopathy.

BACKGROUND The majority of patients with Alzheimer's disease (AD) exhibit amyloid-β (Aβ) deposits at the brain vasculature, a process referred to as cerebral amyloid angiopathy (CAA). In over 51% of AD cases, Aβ also accumulates in cortical capillaries, which is termed capillary CAA (capCAA). It has been postulated that the presence of capCAA in AD is a specific subtype of AD, although underlying mechanisms are not yet fully understood. Sphingolipids (SLs) are implicated in neurodegenerative disorders, including AD. However, to date it remains unknown whether alterations in the SL pathway are involved in capCAA pathogenesis and if these differ from AD. OBJECTIVE To determine whether AD cases with capCAA have an altered SL profile compared to AD cases without capCAA. METHODS Immunohistochemistry was performed to assess the expression and localization of ceramide, acid sphingomyelinase (ASM), and sphingosine-1-phosphate receptors (S1P1, S1P3). In addition, we determined the concentrations of S1P as well as different chain-lengths of ceramides using HPLC-MS/MS. RESULTS Immunohistochemical analysis revealed an altered expression of ceramide, ASM, and S1P receptors by reactive astrocytes and microglial cells specifically associated with capCAA. Moreover, a shift in the balance of ceramides with different chain-lengths and S1P content is observed in capCAA. CONCLUSION Here we provide evidence of a deregulated SL balance in capCAA. The increased levels of ASM and ceramide in activated glia cells suggest that the SL pathway is involved in the neuroinflammatory response in capCAA pathogenesis. Future research is needed to elucidate the role of S1P in capCAA.
Gender differences in the perception of security of mobile phones

In this paper we describe observed gender differences in the perception of security of mobile phones, especially on authentication and payment-related features and application on smartphones. The data was gathered in a focus group, two surveys and an experiment during November 2009 and September 2011. The data shows significant differences in perceived security and future use of security-related features and applications.
Detection of dust aerosol by combining CALIPSO active lidar and passive IIR measurements

Abstract. The version 2 Cloud-Aerosol Lidar and Infrared Pathfinder Satellite Observations (CALIPSO) dust layer detection method, which is based only on lidar measurements, misclassified about 43% dust layers (mainly dense dust layers) as cloud layers over the Taklamakan Desert. To address this problem, a new method was developed by combining the CALIPSO Cloud-Aerosol Lidar with Orthogonal Polarization (CALIOP) and passive Infrared Imaging Radiometer (IIR) measurements. This combined lidar and IR measurement (hereafter, CLIM) method uses the IIR tri-spectral IR brightness temperatures to discriminate between ice cloud and dense dust layers, and lidar measurements alone to detect thin dust and water cloud layers. The brightness temperature difference between 10.60 and 12.05 μm (BTD11−12) is typically negative for dense dust and generally positive for ice cloud, but it varies from negative to positive for thin dust layers, which the CALIPSO lidar correctly identifies. Results show that the CLIM method could significantly reduce misclassification rates to as low as ~7% for the active dust season of spring 2008 over the Taklamakan Desert. The CLIM method also revealed 18% more dust layers having greatly intensified backscatter between 1.8 and 4 km altitude over the source region compared to the CALIPSO version 2 data. These results allow a more accurate assessment of the effect of dust on climate.
Distance to hospital and socioeconomic status influence secondary health care use

Abstract Objective. The aim of this study was to investigate how distance to hospital and socioeconomic status (SES) influence the use of secondary health care (SHC) when taking comorbidity into account. Design and setting. A register-based study in Östergötland County. Subjects. The adult population of Östergötland County. Main outcome measures. Odds of SHC use in the population and rates of SHC use by patients were studied after taking into account comorbidity level assigned using the Adjusted Clinical Groups (ACG) Case-Mix System. The baseline for analysis of SES was individuals with the lowest education level (level 1) and the lowest income (1st quartile). Results. The study showed both positive and negative association between SES and use of SHC. The risk of incurring SHC costs was 12% higher for individuals with education level 1. Individuals with income in the 2nd quartile had a 4% higher risk of incurring SHC costs but a 17% lower risk of emergency department visits. Individuals with income in the 4th quartile had 9% lower risk of hospitalization. The risk of using SHC services for the population was not associated with distance to hospital. Patients living over 40 km from hospital and patients with higher SES had lower use of SHC services. Conclusions. It was found that distance to hospital and SES influence SHC use after adjusting for comorbidity level, age, and gender. These results suggest that GPs and health care managers should pay a higher degree of attention to this when planning primary care services in order to minimize the potentially redundant use of SHC.
Integrity of N‐ and C‐termini is important for E. coli Hsp31 chaperone activity

Hsp31 is a stress‐inducible molecular chaperone involved in the management of protein misfolding at high temperatures and in the development of acid resistance in starved E. coli. Each subunit of the Hsp31 homodimer consists of two structural domains connected by a flexible linker that sits atop a continuous tract of nonpolar residues adjacent to a hydrophobic bowl defined by the dimerization interface. Previously, we proposed that while the bowl serves as a binding site for partially folded species at physiological temperatures, chaperone function under heat shock conditions requires that folding intermediates further anneal to high‐affinity binding sites that become uncovered upon thermally induced motion of the linker. In support of a mechanism requiring that client proteins first bind to the bowl, we show here that fusion of a 20‐residue‐long hexahistidine tag to the N‐termini of Hsp31 abolishes chaperone activity at all temperatures by inducing reversible structural changes that interfere with substrate binding. We further demonstrate that extending the C‐termini of Hsp31 with short His tags selectively suppresses chaperone function at high temperatures by interfering with linker movement. The structural and functional sensitivity of Hsp31 to lengthening is consistent with the high degree of conservation of class I Hsp31 orthologs and will serve as a cautionary tale on the implications of affinity tagging.
Luminal Cholera Toxin Alters Motility in Isolated Guinea-Pig Jejunum via a Pathway Independent of 5-HT3 Receptors

Cholera toxin (CT) is well established to produce diarrhea by producing hyperactivity of the enteric neural circuits that regulate water and electrolyte secretion. Its effects on intestinal motor patterns are less well understood. We examined the effects of luminal CT on motor activity of guinea-pig jejunum in vitro. Segments of jejunum were cannulated at either end and mounted horizontally. Their contractile activity was video-imaged and the recordings were used to construct spatiotemporal maps of contractile activity with CT (1.25 or 12.5 μg/ml) in the lumen. Both concentrations of CT induced propulsive motor activity in jejunal segments. The effect of 1.25 μg/ml CT was markedly enhanced by co-incubation with granisetron (5-HT3 antagonist, 1 μM), which prevents the hypersecretion induced by CT. The increased propulsive activity was not accompanied by increased segmentation and occurred very early after exposure to CT in the presence of granisetron. Luminal CT also reduced the pressure threshold for saline distension evoked propulsive reflexes, an effect resistant to granisetron. In contrast, CT prevented the induction of segmenting contractions by luminal decanoic acid, so its effects on propulsive and segmenting contractile activity are distinctly different. Thus, in addition to producing hypersecretion, CT excites propulsive motor activity with an entirely different time course and pharmacology, but inhibits nutrient-induced segmentation. This suggests that CT excites more than one enteric neural circuit and that propulsive and segmenting motor patterns are differentially regulated.
Clustering of Socioeconomic, Behavioural, and Neonatal Risk Factors for Infant Health in Pregnant Smokers

Background Tobacco smoking is a major cause of morbidity and mortality, including during pregnancy. Although effective ways of promoting smoking cessation during pregnancy exist, the impact of these interventions has not been studied at a national level. We estimated the prevalence of smoking throughout pregnancy in the Netherlands and quantified associations of maternal smoking throughout pregnancy with socioeconomic, behavioural, and neonatal risk factors for infant health and development. Methodology/Principal Findings Data of five national surveys, containing records of 14,553 Dutch mothers and their offspring were analyzed. From 2001 to 2007, the overall rate of smoking throughout pregnancy fell by 42% (from 13.2% to 7.6%) mainly as a result of a decrease among highly educated women. In the lowest-educated group, the overall rate of smoking throughout pregnancy was six times as high as in the highest-educated group (18.7% versus 3.2%). Prenatal tobacco smoke exposure was associated with increased risk of extremely preterm (≤28 completed weeks) (OR 7.25; 95% CI 3.40 to 15.38) and small-for-gestational age (SGA) infants (OR 3.08; 95% CI 2.66 to 3.57). Smoking-attributable risk percents in the population (based on adjusted risk ratios) were estimated at 29% for extremely preterm births and at 17% for SGA outcomes. Infants of smokers were more likely to experience significant alcohol exposure in utero (OR 2.08; 95%CI 1.25 to 3.45) and formula feeding in early life (OR 1.91; 95% CI 1.69 to 2.16). Conclusions The rates of maternal smoking throughout pregnancy decreased significantly in the Netherlands from 2001 to 2007. If pregnant women were to cease tobacco use completely, an estimated 29% of extremely preterm births and 17% of SGA infants may be avoided annually.
Hospitalization for Ambulatory Care Sensitive Conditions (ACSC) in Ile-de-France: A View from Across the Atlantic

This article presents an indicator used in the United States and other OECD nations (hospitalizations for ambulatory-care sensitive conditions – ACSC) to assess access to primary care services and their capacity to handle a set of medical conditions before they require acute hospital treatment. Based on a study of Ile de France, which relies on residence-based hospital discharge data on patient diagnoses and treatments, the indicator identifies areas where hospitalizations for ACSC appear particularly high. Such hospital stays are considered potentially avoidable. Based on data from the Programme de medicalisation des systemes d’information (PMSI), disparities are measured. We rely on logistic regression analysis to identify a range of individual factors and neighborhood-level factors that explain these disparities. Access to primary care appears to be worse among residents in areas with average household income in the lowest quartile and among those hospitalized in public hospitals. This raises an important question for the future of health policy. Should areas with higher hospital discharge rates of ACSC be understood as having populations with poor health-seeking behaviors or health care systems not well enough organized to target higher-risk populations ?
Influence of serum HMW adiponectin level in patients with pregnancy-induced hypertension syndrome on the occurrence of eclampsia in secondary pregnancy

In the present study, we studied the influence of serum high-molecular weight adiponectin (HMWA) levels in patients with pregnancy-induced hypertension (PIH) on the occurrence of eclampsia in secondary pregnancy and its related mechanisms. In total, 130 patients who were diagnosed with PIH for the first time were selected for this study; the median interval of the secondary pregnancy was 28.5 months. The serum HMWA and leptin levels both times were detected, and the insulin resistance indexes (HOMA-IR) were calculated. The serum inflammatory indexes in the secondary pregnancy included interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) levels, and the oxidative stress indexes included methane dicarboxylic aldehyde (MDA) and oxidized low-density lipoprotein (ox-LDL) levels. The expression levels of adiponectin receptor 2 and cyclooxygenase-2 (COX-2) in placental tissue were detected. In secondary pregnancy, there were a total of 20 cases of eclampsia (15.38%), including 2 cases of mild PIH, 8 cases of moderate PIH and 10 cases of severe PIH; differences were statistically significant when compared to patients without eclampsia (p<0.001). The serum HMWA levels in patients with severe PIH in the first pregnancy were significantly lower than those in patients with mild and moderate PIH, and the serum levels in patients with mild PIH were the highest. The leptin levels in patients with severe PIH were significantly higher than those in patients with mild and moderate PIH, and the leptin levels in patients with mild PIH were the lowest (p<0.05). The HMWA levels in patients with eclampsia in the secondary pregnancy was significantly lower than those in patients without eclampsia, and the leptin levels in patients with eclampsia were significantly increased. The HMWA levels in patients with eclampsia in the secondary pregnancy were lower than that in the first pregnancy, whereas the leptin levels were higher than that in the first pregnancy (p<0.05). HOMA-IR, IL-6, TNF-α, MDA and ox-LDL levels in patients with eclampsia were significantly higher than those in patients without eclampsia (p<0.05), and the adiponectin receptor 2 and COX-2 expression levels in the placental tissue were significantly higher than those in patients without eclampsia (p<0.05). Therefore, the serum HMWA levels are closely related to the occurrence of eclampsia in PIH patients in secondary pregnancy, and it influences insulin resistance, inflammatory response and oxidative stress response, which is correlated with increased adiponectin receptor 2 and COX-2 protein expression in placental tissue. Consequently, HMWA may be an important target for the intervention of preventing eclampsia for PIH patients in secondary pregnancy.