Miracle-dz/UniFAR-FTUs huggingface dataset:
Association between Toll-Like Receptor Gene Cluster (TLR6, TLR1, and TLR10) and Prostate Cancer

Background: Chronic inflammation may be a risk factor for prostate cancer. Previously, we found significant associations between single nucleotide polymorphisms (SNPs) and haplotypes in Toll-like receptor (TLR) 4 and the risk of prostate cancer. TLR6, TLR1, and TLR10 are also involved in the pathogen-mediated inflammation pathway. A Swedish study observed associations between sequence variants in the TLR6-TLR1-TLR10 gene cluster and the risk of prostate cancer. We assessed if genetic polymorphisms of this gene cluster were associated with the risk of prostate cancer in a U.S. population. Methods: In a nested case-control design within the Health Professionals Follow-Up Study, we identified 700 participants with prostate cancer who were diagnosed after they had provided a blood specimen in 1993 and by January 31, 2000. Controls were 700 age-matched men without prostate cancer who had had a prostate-specific antigen test. We genotyped 19 common (>5%) haplotype-tagging SNPs chosen from the SNPs discovered in a resequencing study spanning TLR6, TLR1, and TLR10 to test for the association between sequence variants cluster and prostate cancer. Results: Neither individual SNPs nor common haplotypes in the three gene regions were associated with altered risk of prostate cancer or subgroups of aggressive prostate cancer. No effect modification was observed for age, body mass index, or family history of prostate cancer, except that TLR6_3649 showed nominally significant interaction with family history at the P < 0.05 level. Conclusion: Inherited sequence variants of the innate immune gene cluster TLR6-TLR1-TLR10 were not appreciably associated with the risk of prostate cancer in this cohort. (Cancer Epidemiol Biomarkers Prev 2007;16(10):1982–9)
Virtual microscopy for learning and assessment in pathology

Virtual slides are high‐magnification digital images of tissue sections, stored in a multi‐resolution file format. Using appropriate software, these slides can be viewed in a web browser in a manner that closely simulates examination of glass slides with a real microscope. We describe the successful implementation of teaching microscopic pathology with virtual slides and, for the first time, their use in summative assessment. Both students and teaching staff readily adapted to the use of virtual microscopy. Questionnaire feedback from students strongly indicated that virtual slides solved a number of problems in their learning, while providing good to excellent image quality. A deliberate policy of allocating two students per workstation promoted collaboration and helped to maintain interest in microscopic pathology. The use of a secure browser facilitated assessment using virtual slides, with no technical or security issues arising despite high peak demand. The new Medicine programme at the University of New South Wales will exclusively utilize virtual microscopy for the study of both histology and histopathology. We believe that the use of high‐quality learning resources such as virtual slides can ensure that microscopic examination of tissues remains both meaningful and interesting. Copyright © 2004 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Effects of a writing-to-learn tutorial programme in a higher education setting: An interactive qualitative study

ABSTRACT Many higher education students embark on a study of accounting under the misconception that accounting requires a high level of proficiency in manipulating data and being good with numbers, while believing that linguistic competence, especially as it relates to writing, is of less importance. This article reports on a study that examined 15 managerial accounting and financial management (MAFM) students’ experiences of an 18-week writing intensive tutorial programme, based on writing-to-learn principles. Interactive qualitative analysis (IQA) informed the research design and data analysis. Following IQA protocols, nine affinities (themes) were generated. An account of how students’ experiences of a specific affinity, namely, written tasks, influenced their understanding of MAFM concepts is presented. The findings suggest that introducing writing-to-learn assignments contributed positively to students’ learning and understanding of MAFM concepts. This finding has implications for higher education pedagogy especially as it relates to the teaching of the accounting discipline.
Performance Analysis of BGP Security Proposals

Border Gateway Protocol (BGP), the only standard for interdomain routing in the Internet, is used to exchange information between Autonomous Systems (ASes). BGP possesses many security vulnerabilities, as it works with the information received from the neighboring routers, and neighbors can lie, deliberately or mistakenly. Many security approaches have been proposed, but due to reasons like increase in performance overhead, problems in real-world deployment etc, none of them have been adopted as a universal solution so far. In this paper, we discuss and analyze performance of many recently proposed security approaches for BGP and their deployment issues that keep them away from real-time implementation. We also suggest recommendations to reduce processing overheads and to maintain performance vs. security tradeoff.
Metabolic syndrome and periodontitis in Gullah African Americans with type 2 diabetes mellitus.

AIM To assess associations of metabolic syndrome, and its individual components, with extent of severe periodontitis among patients with type 2 diabetes mellitus (T2DM). MATERIALS & METHODS We performed a secondary data analysis (N = 283) using a cross-sectional study population of Gullah African Americans with T2DM. Extent of severe periodontitis was assessed as total diseased tooth-sites/person [evaluated as separate outcomes: 6+mm clinical attachment level (CAL), 5+mm periodontal probing depth (PPD)] using negative binomial regression techniques. Primary independent variables assessed in separate models included metabolic syndrome (yes/no), each metabolic syndrome component (low HDL, hypertension, high triglycerides, large waist circumference) and glycemic control (poor/good). RESULTS Multivariable CAL-model results showed a significant association for metabolic syndrome status with extent of severe periodontitis (RR = 2.77, p = 0.03). The separate multivariable CAL-model including each metabolic syndrome component showed marginally increased rates among those with large waist circumference (RR = 2.33, p = 0.09) and those with HbA1c ≥ 7% (RR = 1.73, p = 0.06). Multivariable PPD-models showed marginally increased rates among those with metabolic syndrome (RR = 2.18, p = 0.06). CONCLUSION Metabolic syndrome is associated with the extent of severe periodontitis in this Gullah population with T2DM.
A Study of Occurrence of Domestic Accidents in Semi-Urban Community

Context: Domestic accidents are worldwide public health problems. The consequences of a domestic accident may prove disastrous as it may result in disability and loss of productivity. In this context, the present study was carried out to characterize the occurrence of domestic accidents in a semi-urban community. Aims: To study the incidence of domestic accident in a semi-urban community and its association with various epidemiological factors. Settings and Design: Community-based cross-sectional study of 796 households consisting of 4086 individuals residing in a semi-urban area. Materials and Methods: Complete information from 796 households consisting of 4086 individuals was collected through semi-structured, pre-tested questionnaire. Domestic accident was considered when any of these individuals had met with an accident inside the house or in the immediate surroundings of the house during the last 6 months from the date of survey. The collected data were tabulated and analyzed. Statistical Analysis Used: Simple proportions and Chi-squared test. Results: The incidence of domestic accidents was found to be 1.7%. The most common accident reported was fall. Occurrence of falls was found to be associated with age and overcrowding. Other accidents noted were burns, scalds, electrocution, injuries and accidental poisoning. Accidents were reported in significantly higher proportion in extreme age groups and in females. Higher proportion of accidents occurred during the morning and evening hours. About 10.1% were treated at home, 72.5% as outdoor patients and 17.4% as indoor patients. The mean duration of hospital stay was found to be 2 weeks. Full recovery was observed in 82.6% cases, whereas permanent disability was found in only 2.9% subjects, while 14.5% reported chronic pain after the accident. No death related to domestic accident was reported in the present study. Conclusions: Domestic accidents are more common in extreme age groups and in females. The reasons may be the higher amount of time spent at home and greater participation in daily home activities. Falls being the most frequent type of accidents, proper designing of house and adequate illumination may help in reducing their occurrence, as the majority of accidents occurred during the morning and evening hours in our study.
The Effects of Fenugreek on Radiation Induced Toxicity for Human Blood T-Cells in Radiotherapy

Many cellular damages either in normal or cancerous tissues are the outcome of molecular events affected by ionizing radiation. T-cells are the most important among immune system agents and are used for biological radiation dose measurement in recommended standard methods. The herbs with immune modulating properties may be useful to reduce the risk of the damages and subsequently the diseases. The T-cells as the most important immune cells being targeted for biological dosimetry of radiation. This study proposes a flowcytometric-method based on fluorescein isothiocyanate- and propidium iodide (PI)-labeled annexin-V to assess apoptosis in blood T-cells after irradiation in both presence and absence of fenugreek extract. T-cells peripheral blood lymphocyte isolated from blood samples of healthy individuals with no irradiated job background. The media of cultured cells was irradiated 1-h after the fenugreek extract was added. The number of apoptotic cells was assessed by annexin-V protocol and multicolor flowcytometry. An obvious variation in apoptotic cells number was observed in presence of fenugreek extract (>80%). The results suggest that fenugreek extract can potentiate the radiation induced apoptosis or radiation toxicity in blood T-cells (P < 0.05).
A critique of Dopfer and Potts's evolutionary realism

Influenced by both the Classical Economics of Malthus and Marx and the Austrian economics of Joseph Schumpeter, Evolutionary Economics has developed into a significant school of economic thought that offers a conception of growth and innovation markedly different to that afforded by neoclassical economics. This paradigm has informed analysis in economic geography and regional economics, and contributed to the development and evaluation of science and technology policy. In Australia, the recent Venturous Australia policy document prepared by Terry Cutler and Associates for the Commonwealth Government, owes much to the Evolutionary Economic way of thinking about innovation. In a recent methodology paper Dopfer and Potts (2004) establish three axioms of 'evolutionary realism' with the intention of illuminating the ontological commitments of Evolutionary Economics. This paper subjects these axioms, and the manner in which they are applied, to a critical interrogation grounded in a comprehensive interpretation of Whitehead's categorical logic. On this basis it is argued that Dopfer and Pott's axiomatic approach lacks in both rigour and depth, thus failing to achieve its methodological objectives. While theoretical cross-overs between thermodynamics and economics are well known, the paper goes on to examine recent developments in nonequilibrium thermodynamics and complexity theory, arguing that Dopfer and Potts provide few insights into how recent developments in non-equilibrium thermodynamics could inform economic analysis.
A Scalable Computational Framework for Establishing Long-Term Behavior of Stochastic Reaction Networks

Reaction networks are systems in which the populations of a finite number of species evolve through predefined interactions. Such networks are found as modeling tools in many biological disciplines such as biochemistry, ecology, epidemiology, immunology, systems biology and synthetic biology. It is now well-established that, for small population sizes, stochastic models for biochemical reaction networks are necessary to capture randomness in the interactions. The tools for analyzing such models, however, still lag far behind their deterministic counterparts. In this paper, we bridge this gap by developing a constructive framework for examining the long-term behavior and stability properties of the reaction dynamics in a stochastic setting. In particular, we address the problems of determining ergodicity of the reaction dynamics, which is analogous to having a globally attracting fixed point for deterministic dynamics. We also examine when the statistical moments of the underlying process remain bounded with time and when they converge to their steady state values. The framework we develop relies on a blend of ideas from probability theory, linear algebra and optimization theory. We demonstrate that the stability properties of a wide class of biological networks can be assessed from our sufficient theoretical conditions that can be recast as efficient and scalable linear programs, well-known for their tractability. It is notably shown that the computational complexity is often linear in the number of species. We illustrate the validity, the efficiency and the wide applicability of our results on several reaction networks arising in biochemistry, systems biology, epidemiology and ecology. The biological implications of the results as well as an example of a non-ergodic biological network are also discussed.
Formal and Informal Social Controls of Employee Deviance

Using the phenomenon of deviance by employees against the rules of the formal work organization as the behavior of interest, the differential saliences of both formal (i.e., management) and informal (i.e., co-worker) sanction severity are empirically compared. As hypothesized, the perceived threat of informal sanctions by one's fellow co-workers explains both property deviance and production deviance far better than the perceived severity of the more formal responses initiated by management. Further, if the two forms of social control are causally ordered, we find that management actions to constrain deviant employees do have an effect, albeit indirect, in that formal sanctions operate on deviance indirectly by shaping the informal sanctions.
Impressions of Liusanjie: a study of motivation, theatrical performance evaluation, and satisfaction

This paper examines the relationships between motivation to visit, performance evaluation, satisfaction, and behavioural intentions for tourists experiencing ‘Impressions of Liusanjie’, an iconic, outdoor, theatrical performance in Guilin, China. The study finds that motivation does not affect satisfaction directly but that performance evaluation is an intervening variable between motivation and satisfaction. It also finds that experiential evaluation of the theatrical performance has more effect on satisfaction than evaluation of technical and functional attributes. Tourists were surveyed after the performance and the results analysed using cluster, correlation analysis and structural equation modelling (SEM). The first two techniques were used to identify existing relationships amongst the study variables. SEM was applied to determine if a causal relationship existed and, if so, their strength. This research provides a contribution to the understanding of tourist motivation, theatrical performance evaluation, satisfaction, and behavioural intentions.
Erectile dysfunction in end-stage liver disease men.

INTRODUCTION In men, erectile dysfunction (ED) is an important issue. Data concerning ED in men with end-stage liver disease (ESLD) is limited, and the risk factors for ED in this population are still unknown. AIMS To determine the prevalence, timescale, and risk factors for ED in ESLD patients candidates to liver transplantation. METHODS Patients candidates for a liver transplantation were asked to participate in a mailed survey about sexual function. Among the 123 eligible men, 98 (84%) agreed to complete the questionnaire. MAIN OUTCOME MEASURES The quality of erection was evaluated using the five-item International Index of Erectile Function (IIEF-5) score, and satisfaction for sexuality, using the patient-baseline Treatment-Satisfaction Scale (TSS) score. Other questions also focused on patient perception of changes over time. RESULTS On the overall population, 28 patients (29%) were nonsexually active. Among the 70 patients who were sexually active, 52 patients (74%) had ED. Regarding the development of ED, 50% of the patients perceived that a deterioration of erectile function occurred within the six previous months. The absence of sexual activity was more frequent in hepatitis B or C patients (P = 0.02). The risk factors for ED were alcohol intake (P = 0.03), tobacco use (P = 0.03), and cardiovascular disease (P = 0.004). The significant risk factors for having a low TSS score were having viral hepatitis (P = 0.01), and cardiovascular disease (P = 0.01). CONCLUSION Population of men with ESLD who are candidates for a liver transplantation is characterized by a high frequency of lack of sexual activity, and by a high prevalence of ED and should be targeted by interventions to improve sexual functioning. These preliminary data need further validation in prospective trial using more comprehensive questionnaires.
Optimization of artemether-loaded NLC for intranasal delivery using central composite design

Abstract The objective of the study was to optimize artemether-loaded nanostructured lipid carriers (ARM-NLC) for intranasal delivery using central composite design. ARM-NLC was prepared by microemulsion method with optimized formulation having particle size of 123.4 nm and zeta potential of −34.4 mV. Differential scanning calorimetry and powder X-ray diffraction studies confirmed that drug existed in amorphous form in NLC formulation. In vitro cytotoxicity assay using SVG p12 cell line and nasal histopathological studies on sheep nasal mucosa indicated the developed formulations were non-toxic and safe for intranasal administration. In vitro release studies revealed that NLC showed sustained release up to 96 h. Ex vivo diffusion studies using sheep nasal mucosa revealed that ARM-NLC had significantly lower flux compared to drug solution (ARM-SOL). Pharmacokinetic and brain uptake studies in Wistar rats showed significantly higher drug concentration in brain in animals treated intranasally (i.n.) with ARM-NLC. Brain to blood ratios for ARM-NLC (i.n.), ARM-SOL (i.n.) and ARM-SOL (i.v.) were 2.619, 1.642 and 0.260, respectively, at 0.5 h indicating direct nose to brain transport of ARM. ARM-NLC showed highest drug targeting efficiency and drug transport percentage of 278.16 and 64.02, respectively, which indicates NLC had better brain targeting efficiency compared to drug solution.
Development and significance of resistance to protease inhibitors in HIV‐1‐infected adults under triple‐drug therapy in clinical practice

Development of drug resistance is considered a major cause for failure of antiretroviral therapy in human immunodeficiency virus type 1 (HIV‐1)‐infected patients adherent to treatment. However, the rate of emergence and the significance of HIV‐1 drug resistance in clinical practice have been not investigated thoroughly. Selection of HIV‐1 variants that are genotypically resistant to protease inhibitors was studied in all the patients (n = 169) who completed at least 18 months of treatment with a protease inhibitor plus two nucleoside reverse transcriptase inhibitors at two urban Italian hospitals. HIV‐1 carrying primary protease inhibitor resistance mutations was detected in 70 (41.4%) patients. The estimated proportion of patients developing genotypic resistance to protease inhibitors at 12 and 24 months was 18.3% (95% CI, 12.5–24.2%) and 33.9% (95% CI, 26.4–41.5%), respectively. Independent predictors of development of resistance to protease inhibitors were higher HIV‐1 RNA levels at the nadir (P < 0.0001) and inclusion of ritonavir or saquinavir versus indinavir in the starting regimen (P = 0.0313). Resistance to protease inhibitors was strongly associated with a lower response to treatment, as shown by HIV‐1 RNA load (P = 0.0001) and CD4 cell counts (P = 0.005). However, a linear increase in CD4 cell counts was maintained up to the end of follow‐up even in the protease inhibitor‐resistant population. Resistance to protease inhibitors develops in a relevant proportion of patients under long‐term triple‐drug therapy in clinical practice and is associated with virological treatment failure and limitation of CD4 cell increase. J. Med. Virol. 66:143–150, 2002. © 2002 Wiley‐Liss, Inc.
CLOUDS: A Decision Tree Classifier for Large Datasets

Classification for very large datasets has many practical applications in data mining. Techniques such as discretization and dataset sampling can be used to scale up decision tree classifiers to large datasets. Unfortunately, both of these techniques can cause a significant loss in accuracy. We present a novel decision tree classifier called CLOUDS, which samples the splitting points for numeric attributes followed by an estimation step to narrow the search space of the best split. CLOUDS reduces computation and I/O complexity substantially compared to state of the art classifiers, while maintaining the quality of the generated trees in terms of accuracy and tree size. We provide experimental results with a number of real and synthetic datasets.