Miracle-dz/UniFAR-FTUs huggingface dataset:
Social Entrepreneurship Research: Past Achievements and Future Promises

The past decade has witnessed a surge of research interest in social entrepreneurship (SE). This has resulted in important insights concerning the role of SE in fostering inclusive growth and institutional change. However, the rapid growth of SE research, the emerging nature of the literature, and the fact that SE builds on different disciplines and fields (e.g., entrepreneurship, sociology, economics, ethics) have led to a rather fragmented literature without dominant frameworks. This situation risks leading to a duplication of efforts and hampers cumulative knowledge growth. Drawing on 395 peer-reviewed articles on SE, we (1) identify gaps in SE research on three levels of analysis (i.e., individual, organizational, institutional), (2) proffer an integrative multistage, multilevel framework, and (3) discuss promising avenues for further research on SE.
Municipal Benefits of a Mobile Government solution: a Study of the Swedish Cases

Mobile government (m-government) provides a high potential to facilitate internal work processes, improve the quality of service, and increase performance of organizations in the public sector. However, only a few investigations have been conducted to explore this research area. And we lack of knowledge of evaluating the value and benefits of m-government solutions. In the paper, we identify and analyse the benefits of a mobile government solution for problem and complaint management by adopting the PENG model. Data are collected from case studies of two municipalities in Sweden. We perform thematic analysis of the data. The results reveal two main benefits of the m-government solution. Firstly, it helps the municipalities to enhance their innovative appearance and increase transparency in administration, which result in an improved social image. Secondly, the solution provides a number of benefits that have an impact on the municipalities and citizens. In particular, these benefits include an improved quality of public service, reduced costs and improved democracy. Moreover, we summarize the strengths and weaknesses of the PENG model that arises in the study. This paper contributes knowledge to the research of mobile government and increases the understanding of benefit analysis of mobile solutions for public organizations.
Single-molecule observation of DNA compaction by meiotic protein SYCP3

In a previous paper (Syrjänen et al., 2014), we reported the first structural characterisation of a synaptonemal complex (SC) protein, SYCP3, which led us to propose a model for its role in chromosome compaction during meiosis. As a component of the SC lateral element, SYCP3 has a critical role in defining the specific chromosome architecture required for correct meiotic progression. In the model, the reported compaction of chromosomal DNA caused by SYCP3 would result from its ability to bridge distant sites on a DNA molecule with the DNA-binding domains located at each end of its strut-like structure. Here, we describe a single-molecule assay based on optical tweezers, fluorescence microscopy and microfluidics that, in combination with bulk biochemical data, provides direct visual evidence for our proposed mechanism of SYCP3-mediated chromosome organisation. DOI: http://dx.doi. org/10.7554/eLife.22582. 001
Characterisation of Mesothelioma-Initiating Cells and Their Susceptibility to Anti-Cancer Agents

Malignant mesothelioma (MM) is an aggressive type of tumour causing high mortality. One reason for this paradigm may be the existence of a subpopulation of tumour-initiating cells (TICs) that endow MM with drug resistance and recurrence. The objective of this study was to identify and characterise a TIC subpopulation in MM cells, using spheroid cultures, mesospheres, as a model of MM TICs. Mesospheres, typified by the stemness markers CD24, ABCG2 and OCT4, initiated tumours in immunodeficient mice more efficiently than adherent cells. CD24 knock-down cells lost the sphere-forming capacity and featured lower tumorigenicity. Upon serial transplantation, mesospheres were gradually more efficiently tumrigenic with increased level of stem cell markers. We also show that mesospheres feature mitochondrial and metabolic properties similar to those of normal and cancer stem cells. Finally, we show that mesothelioma-initiating cells are highly susceptible to mitochondrially targeted vitamin E succinate. This study documents that mesospheres can be used as a plausible model of mesothelioma-initiating cells and that they can be utilised in the search for efficient agents against MM.
Correlation of antemortem serum creatine kinase, creatine kinase-MB, troponin I, and troponin T with cardiac pathology.

BACKGROUND Spurious increases in serum troponins, especially troponin T, have been reported in patients with and without acute myocardial syndromes. METHODS We studied 78 autopsied patients without clinical myocardial infarction (MI) and correlated histologic cardiac findings with antemortem serum creatine kinase (CK), its MB isoenzyme (CK-MB), cardiac troponin I (cTnI), and cardiac troponin T (cTnT). RESULTS There was no significant myocardial pathology in 15 patients. Cardiac pathologies were in five groups: scarring from previous MI or patchy ventricular fibrosis (n = 9), recent MI (n = 27), healing MI (n = 7), degenerative myocyte changes consistent with congestive heart failure (CHF; n = 12), and other cardiac pathologies (n = 8). The median concentrations in the five groups were not significantly different for either CK or CK-MB. Compared with the no-pathology group, only the MI group was significantly different for cTnI, and the MI and other pathology groups were significantly different for cTnT. For patients with MI, 22%, 19%, 48%, and 65% had increased CK, CK-MB, cTnI, and cTnT, respectively; for CHF and other cardiac pathologies combined, the percentages were 28%, 17%, 22%, and 50%. For patients with increased cTnI, 72% and 28% had MI and other myocardial pathologies, respectively; patients with increased cTnT had 64% and 36%, respectively. Patients without myocardial pathology had no increases in CK-MB, cTnI, or cTnT. CONCLUSIONS All patients with increased serum CK-MB, cTnI, and cTnT had significant cardiac histologic changes. The second-generation cTnT assay appears to be a more sensitive indicator of MI and other myocardial pathologies than the cTnI assay used in this study.
High-Risk Acute Coronary Syndrome in a Patient with Coronary Subclavian Steal Syndrome Secondary to Critical Subclavian Artery Stenosis

Patients with multivessel coronary artery disease are more likely to have extensive atherosclerosis that involves other major arteries. Critical subclavian artery (SCA) stenosis can result in coronary subclavian steal syndrome that may present as recurrent ischemia and even myocardial infarction in patients with coronary artery bypass graft (CABG). In patients with concomitant severe native coronary disease, occluded saphenous venous grafts (SVG) to other arteries, percutaneous intervention on critical subclavian artery (SCA) stenosis that will compromise the blood flow to left internal mammary graft (LIMA) and left anterior descending (LAD) artery will be a high-risk procedure and may be associated with cardiogenic shock, especially in patients with preexisting ischemic cardiomyopathy. The use of percutaneous left ventricular (LV) assist device like Impella will offer better hemodynamic support and coronary perfusion and therefore results in decreased myocardial damage, maximized residual cardiac function, and lower incidence of cardiogenic shock.
Phase II study of a triplet regimen of S-1 combined with irinotecan and oxaliplatin in patients with metastatic gastric cancer: clinical and pharmacogenetic results.

BACKGROUND The aim of this study was to investigate the efficacy and safety of S-1/irinotecan/oxaliplatin (TIROX) in metastatic gastric cancer (MGC) and the association between treatment outcome and uridine diphosphate-glucuronosyltransferase (UGT) 1A polymorphisms. PATIENTS AND METHODS Patients with previously untreated MGC received S-1 40 mg/m(2) b.i. d. on days 1-14 and irinotecan 150 mg/m(2) plus oxaliplatin 85 mg/m(2) on day 1 every 3 weeks. RESULTS Forty-four patients were enrolled. In intent-to-treat analysis, the objective response rate was 75%, including the complete response (CR) rate of 14%. The median time to progression and overall survival was 10.2 and 17.6 months, respectively. Ten (26%) of the 39 patients with primary gastric tumor showed biopsy-confirmed gastric CR. Grade 3/4 neutropenia developed in 66% of patients and grade 3 febrile neutropenia in 16%. The most common grade 3 nonhematologic toxic effects were abdominal pain (18%), anorexia (16%), and diarrhea (14%). UGT1A polymorphisms were associated with significantly higher incidence of grade 4 leukopenia (UGT1A1*6), neutropenia (UGT1A1*6, UGT1A6*2, and UGT1A7*3), grade 3/4 febrile neutropenia (UGT1A1*6), and grade 3 abdominal pain (UGT1A1*6). CONCLUSIONS The TIROX regimen induced marked tumor reduction and promising survival with a manageable toxicity profile in MGC patients. UGT1A genotype may be predictive of TIROX toxicity.
Introduction : Mechanisms of Ocular Dominance Plasticity

Preface Have you ever realized that the language you have learned when you were young, the language you grew up with, will always be more permanent then any language you learn later in life? It does not matter what language you come in contact with in the rest of your lifetime, or how well you understand the ins and outs of such communication. You will think, write and talk in your native language better than any other and it will take a tremendous effort to lose this preference. Not only language but also the familiarities of your environment when you grow up, your mothers smell, her voice, the sounds, the images, the temptations in life and other sensory information that you take up and experience will make you into who you are. It will render you unique in the sense that no other has experienced exactly this pattern of coming into contact with the world. Besides this you might learn how to for example ride a bike, study mathematics, and play sports. You adopt intricate motor programs that will stay dormant for years if necessary and pop-up at any useful occasion. All this mostly really is like riding a bike. All of these properties can be learned more easily when you are young. It makes sense to develop these properties early in life in a permanent way so they will be advantageous in your further life. Knowing what mechanisms underlie the switch from a time where we learn more easily to an age where learning requires much more effort has been the interest of decades of research. Plasticity One of the most important abilities of the brain is to adapt and change under influence of our environment. This can include visual or auditory stimuli, the sense of touch or social interactions. These adaptations can be initiated, modulated and ended, and depend on the genetic programs of the cells in our brain enabling them to strengthen or weaken the neuronal connectivity upon experience. This process is called plasticity (Hebb, 1949). Plasticity can also occur when normal experience is changed due to injury or disease. The cortical structures where this plasticity occurs are built up of intricate networks of (largely glutamatergic) excitatory and GABAergic inhibitory neurons (Douglas and Martin, 2007; Brown and Hestrin, 2009). Either structural changes or changes in the strength of neuronal connections within such circuits are a hallmark of …
Central retinal thickness measured with HD-OCT shows a weak correlation with visual acuity in eyes with CSME

Aims To investigate the correlation between increased retinal thickness (RT) measured with spectral domain high-definition optical coherence tomography (OCT) (Cirrus HD-OCT (Carl Zeiss Meditec, Dublin, California, USA)) and best-corrected visual acuity (BCVA) in eyes with clinically significant macular oedema (CSME) and type 2 diabetes. Methods Seventy eyes with CSME were included in this observational study. Sixty-two eyes were considered for analysis and were classified as having/not having retinal thickening in the central fovea (central 500-μm-diameter circle) by Cirrus HD-OCT. RT measurements were computed and correlated with BCVA. For comparison purposes, the Stratus OCT (Carl Zeiss Meditec, Dublin, California, USA) central point thickness was also obtained in these eyes. Results In the 19 eyes with CMSE identified by Cirrus HD-OCT without increased RT in the central fovea (500-μm-diameter circle), no correlation was found between RT and BCVA (R=0.062; 95% CI −0.404 to 0.502). In the 43 eyes where the Cirrus HD-OCT identified an increased RT in the central fovea (central 500-μm-diameter circle), only a moderate correlation between RT and BCVA was found (R=−0.459; 95% CI −0.667 to −0.184). Conclusion Correlations between RT and BCVA in CSME are only present when the central 500-μm-diameter circle is involved. However, even in this circumstance, a correlation was found in only 48.8% of the cases. RT cannot, therefore, be used as a surrogate outcome for visual acuity changes.
Magnetic susceptibility of insulators from first principles.

We present an {ital ab} {ital initio} approach for the computation of the magnetic susceptibility {chi} of insulators. The approach is applied to compute {chi} in diamond and in solid neon using density functional theory in the local density approximation, obtaining good agreement with experimental data. In solid neon, we predict an observable dependence of {chi} upon pressure. {copyright} {ital 1996 The American Physical Society. }
The relationship between regular physical activity with spiritual intelligence and psychological well-being among the elderly in Tehran

Background and Objective: This study aimed to examine the relationship between regular physical activity with spiritual intelligence and psychological well-being among the elderly in Tehran. Method: The study adopted a cross-sectional design. The study population included all the seniors (over 60 years old) living in Tehran. In total, 200 participants were selected through purposive convenience sampling. Data were collected using King’s Spiritual Intelligence Self-Report Inventory, International Physical Activity Questionnaire, Ryff’s Psychological Well-being Questionnaire, and a demographic questionnaire. Pearson product moment correlation and linear regression were employed for data analysis. All ethical issues were observed in this study and the researchers declared no conflict of interests. Results: The obtained results indicated a significant positive relationship between spiritual intelligence (and all its subscales) and regular physical activity (P≥ 0.05). Furthermore, three subscales of psychological well-being (namely individual growth, positive communications with others, and self-acceptance) significantly correlated with regular physical activity (P≥ 0.05). It was also found that seniors’ spiritual intelligence and psychological well-being were measurably interrelated (P≥ 0.05).
Comparison of Procedural Sedation for the Reduction of Dislocated Total Hip Arthroplasty

Introduction: Various types of sedation can be used for the reduction of a dislocated total hip arthroplasty. Traditionally, an opiate/benzodiazepine combination has been employed. The use of other pharmacologic agents, such as etomidate and propofol, have more recently gained popularity. Currently no studies directly comparing these sedation agents have been carried out. The purpose of this study is to compare differences in reduction and sedation outcomes, including recovery times, of these 3 sedation agents. Methods: We performed a retrospective chart review examining 198 patients who presented with dislocated total hip arthroplasty at 2 academic affiliated medical centers. The patients were grouped according to the type of sedation agent. We calculated percentages of reduction and sedation complications along with recovery times. Reduction complications included fracture, skin or neurovascular injury, and failure of reduction requiring general anesthesia. Sedation complications included use of bag-valve mask and artificial airway, intubation, prolonged recovery, use of a reversal agent, and inability to achieve sedation. We then compared the data for each sedation agent. Results: We found reduction complications rates of 8.7% in the propofol, 24.7% in the etomidate, and 28.9% in the opiate/benzodiazepine groups. The propofol group was significantly different from the other 2agents (p ≤ 0.01). Sedation complications were found 7.3% of the time in the propofol , 11.7% in the etomidate , and 21.3% in the opiate/benzodiazepine group, (p=0.02 propofol vs. others) . Average recovery times were 25.2 minutes for propofol, 30.8 minutes for etomidate, and 44.4 minutes for opiate/benzodiazepine (p = 0.05 for propofol vs. other agents). Conclusion: For reduction of dislocated total hip arthroplasty under procedural sedation, propofol appears to have fewer complications and a trend toward more rapid recovery than both etomidate and opiate/benzodiazepine. These data support the use of propofol as first line agent for procedural sedation of dislocated total hip arthroplasty, with fewer complications and a shorter recovery period.
Factors influencing plagiarism by accounting lecturers

ABSTRACT This study examines the possible factors affecting plagiarism by accounting lecturers in the Special Region of Yogyakarta, a province in Indonesia. 108 completed questionnaires were quantitatively analyzed. The multiple regression analysis reveals that working pressure and unfair competition significantly influence the intention to undertake plagiarism. These results indicate that Fraud Triangle theory partially explains the phenomenon of plagiarism among accounting lecturers. The main implication of this research is that accounting lecturers have overload works in their daily activities so that they do not have enough time to write scientific works professionally. Another implication is the presence of an unfair competition among accounting lecturers so that in order to meet the publication target, plagiarism becomes a way. The important contribution of this paper is the finding regarding the influences of working pressure and unfair competition on plagiarism by accounting lecturers.
ON CHAOS OF THE LOGISTIC MAPS

This paper is concerned with chaos of a family of logistic maps. It is first proved that a regular and nondegenerate snap-back repeller implies chaos in the sense of both Devaney and Li-Yorke for a map in a metric space. Based on this result, it is shown that the logistic system is chaotic in the sense of both Devaney and Li-Yorke, and has uniformly positive Lyapunov exponents in an invariant set for a certain parameter interval with a lower bound less than a specific value, at which the unique 3-periodic orbit appears. In addition, it shows the exact parameter range for the existence of an asymptotically stable 3-periodic point, and consequently the exact parameter range for the biggest periodic window, i.e., 3-periodic window, in the period-doubling bifurcation diagram.
Feature encoding for unsupervised segmentation of color images

In this paper, an unsupervised segmentation method using clustering is presented for color images. We propose to use a neural network based approach to automatic feature selection to achieve adaptive segmentation of color images. With a self-organizing feature map (SOFM), multiple color features can be analyzed, and the useful feature sequence (feature vector) can then be determined. The encoded feature vector is used in the final segmentation using fuzzy clustering. The proposed method has been applied in segmenting different types of color images, and the experimental results show that it outperforms the classical clustering method. Our study shows that the feature encoding approach offers great promise in automating and optimizing the segmentation of color images.
Association of Insulin Resistance with Chronic Kidney Disease in Non-Diabetic Subjects with Normal Weight

Objective To the best of our knowledge, the association of insulin resistance (IR) with chronic kidney disease (CKD) has not been well studied in normal-weight individuals. The aim of this study is to examine whether IR is associated with CKD in non-diabetic subjects with normal weight. We also examine whether the presence of obesity modifies the association of IR with CKD. Methods Data were drawn from a cross-sectional survey in China. Both estimated glomerular filtration rate and urinary albumin to creatinine ratio were used as markers of CKD. Logistic regression models and the quartiles of homeostatic model assessment of insulin resistance were used to explore the associations of IR with CKD in entire cohort, normal-weight and overweight/obese subpopulations. Results In normal-weight subpopulation, the prevalence of IR and metabolic syndrome were 11.11% and 8.99%, respectively. In the entire cohort, the highest quartile HOMA-insulin resistance had a 70% increased risk for CKD (RR 1.70, 95% CI 1.07, 2.71, P=0.03, comparing the highest to the lowest quartile). However, when adding obesity to the model, the association was abolished. IR was associated with CKD in overweight/obese subpopulation but not in normal-weight subpopulation. Conclusion IR and MetS in normal-weight individuals is common in the Chinese population. IR is associated with CKD in overweight/obese subpopulation but not in normal-weight subpopulation and the presence of obesity modifies the association of IR with CKD.
Innovations in Credit Risk Transfer: Implications for Financial Stability

Banks and other lenders often transfer credit risk to liberate capital for further loan intermediation. This paper aims to explore the design, prevalence and effectiveness of credit risk transfer (CRT). The focus is on the costs and benefits for the efficiency and stability of the financial system. After an overview of recent credit risk transfer activity, the following points are discussed: motivations for CRT by banks; risk retention; theories of CDO design; specialty finance companies. As an illustration of CLO design, an example is provided showing how the credit quality of the borrowers can deteriorate if efforts to control their default risks are costly for issuers. An appendix is provided on CDS index tranches.
The Role of Auditory and Premotor Cortex in Sensorimotor Transformations

This review first summarizes three functional magnetic resonance imaging studies conducted to elucidate the neural basis for interactions between the auditory and motor systems in the context of musical rhythm perception and production. The second part of the paper discusses these findings in the context of a proposed model for auditory–motor interactions that engage the posterior aspects of the superior temporal gyrus, and the ventral and dorsal premotor cortex. In the last section, we present outstanding issues that encompass topics, such as the role of auditory versus parietal cortex in sensorimotor integration, sensorimotor integration as an emergent property, the role of mirror neurons, and clinical applications.