Miracle-dz/UniFAR-FTUs huggingface dataset:
Hemiepiphyseodesis for Late-Onset Tibia Vara

Background: The amount of correction obtained with tibial and/or femoral hemiepiphyseodesis in late-onset tibia vara is quite variable. The purpose of this study is to identify preoperative factors which might help to predict the amount of correction that is obtainable. Methods: Fifty-three patients (67 knees) have been treated with hemiepiphyseodesis and followed until skeletal maturity or a secondary realignment procedure before maturity. The amount of correction obtained was correlated with multiple preoperative factors including age, body weight, and degree of deformity. Results: In 65 limbs treated with tibial hemiepiphyseodesis, the average correction in the tibia was 9 degrees, ranging widely from 33 degrees of correction to 6 degrees worsening of the deformity. In 22 limbs treated with femoral hemiepiphyseodesis, the average correction in the femur was 8 degrees (range, 0-19 degrees). Ultimately, 19 of the 67 limbs have been treated with an osteotomy and 10 more were left with greater than 10 degrees of varus deformity at maturity. In addition, 14 of the 67 limbs overcorrected into excessive valgus and/or required medial hemiepiphyseodesis procedures to prevent overcorrection. Using multiple regression analysis it was found that younger age and lesser deformity were weakly predictive of greater correction with tibial hemiepiphyseodesis. No factors were statistically significant predictors of femoral correction. Conclusions: Variable amounts of correction are obtained with hemiepiphyseodesis in patients with late-onset tibia vara. Even very large amounts of correction may be obtainable in some cases, but unfortunately preoperative factors such as age, weight, and degree of deformity cannot be relied upon in clinical practice to predict outcome. Surgical decision making must weigh the safety and simplicity of this procedure against the much more extensive but much more predicable realignment obtained with osteotomy procedures. Level of Evidence: Level IV; retrospective and prospective longitudinal evaluation of a case series.
Pediatric Intestinal Failure Associated Liver Disease is Revered with Six Months of Intravenous Fish Oil

OF THE THESIS Pediatric intestinal failure associated liver disease (IFALD) is associated with a high morbidity and mortality. Studies have suggested that when intravenous (IV) soybean oil (SO) is replaced with fish oil (FO), direct hyperbilirubinemia is more likely to resolve. The necessary duration of FO has not been established. This study seeks to determine if 24 weeks of FO is an effective and safe therapy for IFALD.
Community-acquired bacterial meningitis in adults.

This review summarizes recent changes in the treatment of adults with community-acquired bacterial meningitis. It explains the initial assessment and management, the use of adjunctive corticosteroids, and intensive care monitoring. The authors detail the approach to complications such as transtentorial herniation, hydrocephalus, and focal seizures.
Identification of the Amyloid-Degrading Enzyme Neprilysin in Mouse Islets and Potential Role in Islet Amyloidogenesis

Islet amyloid contributes to loss of β-cell mass and function in type 2 diabetes. It is poorly understood how the building block of amyloid, islet amyloid polypeptide (IAPP), misfolds and accumulates within the islet to contribute to cellular dysfunction. We sought to determine whether neprilysin, an amyloid-degrading enzyme, is present in islets and plays a role in the accumulation of amyloid fibrils. Human IAPP (hIAPP) transgenic mice, a model of islet amyloid in which primarily male mice develop amyloid by 12 months of age, were studied at 10 weeks and 6 months of age, enabling investigation of islet changes before and during early amyloidogenesis. Neprilysin was present in islets, including β-cells, and islet neprilysin mRNA and activity were found to decline with age in nontransgenic mice as well as in hIAPP transgenic female mice. In contrast, neprilysin mRNA and activity did not decrease in amyloid-prone hIAPP transgenic male mice at 6 months compared with nontransgenic mice and female hIAPP transgenic mice. Islet amyloid was detected in 43% of the 6-month-old hIAPP transgenic male mice only, suggesting the sustained elevation of islet neprilysin in these mice was a compensatory mechanism aimed at preventing amyloid accumulation. In keeping with amyloid formation, the proportion of insulin-positive area to islet area was significantly reduced in 6-month-old hIAPP transgenic male mice, which also displayed mild fasting hyperglycemia compared with age-matched transgenic female and nontransgenic mice. Together, these findings demonstrate that neprilysin is a factor associated with islet amyloid accumulation and subsequent deterioration of β-cell function in hIAPP transgenic male mice.
Optimal conditions of mycelia growth of Laetiporus sulphureus sensu lato

Laetiporus sulphureus is an edible wood-rotting basidiomycete, growing on decaying logs, stumps, and trunks of many deciduous and coniferous tree species. This fungus produces relatively large striking yellowish or orange-coloured bracket-like fruitbodies. L. sulphureus is widely consumed as a nutritional food because of its fragrance and texture. In this study, two L. sulphureus strains, MFLUCC 12-0546 and MFLUCC 12-0547, isolated from Chiang Rai, Thailand, were investigated for optimal conditions of mycelia growth. Potato dextrose agar and malt extract agar were observed as the favourable medium for mycelia growth. The optimum pH and temperature for the mushroom mycelia were 6–8 and 25–30°C, respectively.
Evaluation of Possible Prognostic Factors for the Success, Survival, and Failure of Dental Implants

Purpose:To analyze the prognostic factors that are associated with the success, survival, and failure rates of dental implants. Material and Methods:Data including implant sizes, insertion time, implant location, and prosthetic treatment of 1656 implants have been collected, and the association of these factors with success, survival, and failure of implants was analyzed. Results:The success rate was lower for short and maxillary implants. The failure rate of maxillary implants exceeded that of mandibular implants, and the failure rate of implants that were placed in the maxillary anterior region was significantly higher than other regions. The failure rates of implants that were placed 5 years ago or more were higher than those that were placed later. Conclusions:Anterior maxilla is more critical for implant loss than other sites. Implants in the anterior mandible show better success compared with other locations, and longer implants show better success rates. The learning curve of the clinician influences survival and success rates of dental implants.
The alteration history of the Jbilet Winselwan CM carbonaceous chondrite: An analog for C‐type asteroid sample return

Jbilet Winselwan is one of the largest CM carbonaceous chondrites available for study. Its light, major, and trace elemental compositions are within the range of other CM chondrites. Chondrules are surrounded by dusty rims and set within a matrix of phyllosilicates, oxides, and sulfides. Calcium‐ and aluminum‐rich inclusions (CAIs) are present at ≤1 vol% and at least one contains melilite. Jbilet Winselwan is a breccia containing diverse lithologies that experienced varying degrees of aqueous alteration. In most lithologies, the chondrules and CAIs are partially altered and the metal abundance is low (<1 vol%), consistent with petrologic subtypes 2.7–2.4 on the Rubin et al. ( ) scale. However, chondrules and CAIs in some lithologies are completely altered suggesting more extensive hydration to petrologic subtypes ≤2.3. Following hydration, some lithologies suffered thermal metamorphism at 400–500 °C. Bulk X‐ray diffraction shows that Jbilet Winselwan consists of a highly disordered and/or very fine‐grained phase (73 vol%), which we infer was originally phyllosilicates prior to dehydration during a thermal metamorphic event(s). Some aliquots of Jbilet Winselwan also show significant depletions in volatile elements such as He and Cd. The heating was probably short‐lived and caused by impacts. Jbilet Winselwan samples a mixture of hydrated and dehydrated materials from a primitive water‐rich asteroid. It may therefore be a good analog for the types of materials that will be encountered by the Hayabusa‐2 and OSIRIS‐REx asteroid sample‐return missions.
Characteristics of populations of granulosa cells from individual follicles in women undergoing 'coasting' during controlled ovarian stimulation (COS) for IVF.

BACKGROUND The aim of this study was to evaluate the functional characteristics of granulosa cell populations of individual follicles of women undergoing controlled ovarian stimulation (COS) for IVF/ICSI in whom gonadotrophin had been withheld ('coasted') for the prevention of OHSS. METHODS Follicular fluid and granulosa cells were isolated from 224 individual follicles in 41 women who had been coasted and from 257 individual follicles in 50 women who had a 'normal' response to COS. Cells were cultured at 10,000 cells per well, to evaluate progesterone secretion. Follicular fluid was assayed for progesterone and estradiol (E2). RESULTS No significant differences were observed between the two groups with respect to granulosa cell number or follicular fluid progesterone and E2 and follicle size, the retrieval of an oocyte and the subsequent fertilization of the oocyte. However, the granulosa cells derived from the coasted group showed a higher rate of progesterone secretion per cell at 72 h which was sustained for longer. Differences were also seen at 72 and 120 h of culture with a loss of correlation between progesterone secretion and follicle diameter in the coasted group. CONCLUSIONS Our findings suggest that coasting has an effect on the functional capacity of the granulosa cells and the duration of their function. It is likely that in women at risk of OHSS who are not coasted, the granulosa cells have the capacity to produce significantly more chemical mediators per cell and for a more prolonged period of time.
The role of condensed tannins in the nutritional value of Lotus pedunculatus for sheep

1. Primary growth vegetative Lotus pedunculatus containing 46 and 106 g/kg dry matter (DM) of total condensed tannin and 3 and 14 g/kg DM of free condensed tannin, was cut and fed fresh at hourly intervals (750 g DM/d) to sheep fitted with permanent cannulas into the rumen and duodenum. Low- and high-tannin lotus contained respectively 41.3 and 31.6 g total nitrogen/kg DM and 132 and 152 g lignin/kg DM. The two forms of lotus were similar in carbohydrate composition. 2. Nutrient intake was recorded and faecal output measured by direct collection. Digesta flow to the duodenum was estimated by measuring dilution at the duodenum of inert ruthenium phenanthroline (Ru-P) and chromium-EDTA markers continuously infused into the rumen. 3. Effects attributable to condensed tannins were assessed by comparing the digestion of the two diets, and by comparing the digestion of each with predicted values for non-tannin-containing fresh forages fed at similar intakes. 4. Apparent digestibility of all nutrients measured was less for high- than for low-tannin lotus (P < 0.01). The levels of cellulose digested ruminally and post-ruminally in both forms of lotus were similar to predicted values. However, less hemicellulose and readily fermentable carbohydrate (RFC; soluble carbohydrate + pectin) was digested in the rumen in sheep given both forms of lotus than would be predicted for non-tannin-containing fresh forage diets, but this was compensated for by greater post-ruminal absorption of both nutrients. 5. Total N gains across the rumen (duodenal N flow – total N intake) were 1.8 and 10.5 g/d for low- and high-tannin lotus v. predicted losses of 3.7 and 2.1 g/d for non-tannin-containing fresh forages given at the same total N intakes. Post-ruminal digestion of non-amonia-N (NAN; proportion NAN flowing at duodenum) was 0.71 and 0.67 for low- and high-tannin lotus respectively v. 0.76 for comparable non-tannin-containing fresh forages. Energy absorbed as amino acids from the small intestine was calculated to be 0.29 of metabolizable energy for both forms of lotus, compared with 0.17 and 0.21 for perennial ryegrass and white clover. 6. It was concluded that the presence of condensed tannins in lotus markedly increased post-ruminal NAN absorption compared with non-tannin-containing fresh forage diets, but depressed ruminal digestion of RFC and hemicellulose.
Centennial-Scale Temperature Change in Last Millennium Simulations and Proxy-Based Reconstructions

Systematic comparisons of proxy-based reconstructions and climate model simulations of past millennium temperature variability offer insights into climate sensitivity and feedback mechanisms, besides allowing model evaluation independently from the period covered by instrumental data. Such simulation–reconstruction comparisons can help to distinguish more skillful models from less skillful ones, which may subsequently help to develop more reliable future projections. This study evaluates the low-frequency simulation–reconstruction agreement within the past millennium through assessing the amplitude of temperature change between the Medieval Climate Anomaly (here, 950–1250 CE) and the Little Ice Age (here, 1450–1850 CE) in PMIP3 model simulations compared to proxy-based local and continental-scale reconstructions. The simulations consistently show a smaller temperature change than the reconstructions for most regions in the Northern Hemisphere, but not in the Southern Hemisphere, as well as a partly different spatial pattern. A cost function analysis assesses how well the various simulations agree with reconstructions. Disregarding spatial correlation, significant differences are seen in the agreement with the local temperature reconstructions between groups of models, but insignificant differences are noted when compared to continental-scale reconstructions. This result points toward a limited possibility to “rank” models by means of their low-frequency temperature variability alone. The systematically lower amplitude of simulated versus reconstructed temperature change indicates either too-small simulated internal variability or that the analyzed models lack some critical forcing or have missing or too-weak feedback mechanisms. We hypothesize that too-cold initial ocean conditions in the models—in combination with too-weak internal variability and slow feedbacks over longer time scales—could account for much of the simulation–reconstruction disagreement.
Perceptual Design of Haptic Icons

The bulk of applications for haptic feedback employ direct rendering approaches wherein a user touches a virtual model of some "real" thing, often displayed graphically as well. We propose a new class of applications based on abstract messages, ranging from "haptic icons" - brief signals conveying an ob- ject's or event's state, function or content - to an expressive haptic language for interpersonal communication. Building this language requires us to understand how synthetic haptic signals are perceived, and what they can mean to us. Experiments presented here address the perception question by using an effi- cient version of Multidimensional Scaling (MDS) to extract perceptual axes for complex haptic icons: once this space is mapped, icons can be designed to maximize both differentiability and individual salience. Results show that a set of icons constructed by varying the frequency, magnitude and shape of 2-sec, time-invariant wave shapes map to two perceptual axes, which differ depending on the signals' frequency range; and suggest that expressive capability is maxi- mized in one frequency subspace.
Validation of antroduodenal motility measurements made by echo‐planar magnetic resonance imaging

Echo planar imaging, a development of magnetic resonance imaging, can produce snapshot images of the stomach and antroduodenal segment in as little as 64 msec and can be more useful than conventional techniques when assessing motility. The aim of this study was to compare antroduodenal motility measured by simultaneous perfused tube manometry and echo planar imaging. Ten volunteers were studied following the ingestion of 500 mL water or 500 mL porridge. Antroduodenal images, with acquisition times of 130 msec, were taken at 3‐sec intervals, synchronized with motility traces and presented as a split‐screen video. This allowed direct visual comparison of gastric wall movement and motility to be made. Contractions were confined to either the stomach or the duodenum or propagated across the antroduodenal segment. Over 4550 images were available for analysis. A larger number of propagated contractions were recorded with echo planar imaging in both water (P = 0.03) and food (P = 0.02) groups, whereas manometry detected a greater number of isolated duodenal pressure waves (P = 0.005). The contraction rate for water and food studies was similar, but direct visualization indicated that the manometric technique under‐detected propagated events. The ability of echo planar imaging to record antroduodenal contractile activity provides a new insight into the role of occlusive and nonocclusive contractions during gastric emptying.
Bmc Developmental Biology Zebrafish Con/disp1 Reveals Multiple Spatiotemporal Requirements for Hedgehog-signaling in Craniofacial Development

Background: The vertebrate head skeleton is derived largely from cranial neural crest cells (CNCC). Genetic studies in zebrafish and mice have established that the Hedgehog (Hh)-signaling pathway plays a critical role in craniofacial development, partly due to the pathway's role in CNCC development. Disruption of the Hh-signaling pathway in humans can lead to the spectral disorder of Holoprosencephaly (HPE), which is often characterized by a variety of craniofacial defects including midline facial clefting and cyclopia [1,2]. Previous work has uncovered a role for Hh-signaling in zebrafish dorsal neurocranium patterning and chondrogenesis, however Hh-signaling mutants have not been described with respect to the ventral pharyngeal arch (PA) skeleton. Lipid-modified Hh-ligands require the transmembrane-spanning receptor Dispatched 1 (Disp1) for proper secretion from Hh-synthesizing cells to the extracellular field where they act on target cells. Here we study chameleon mutants, lacking a functional disp1(con/disp1).
Doctor-reported hospital management of acute coronary syndrome in China: A nationwide survey of 1029 hospitals in 30 provinces

Background: Despite recent improvements in the hospital treatment of ACS, little is known about current cardiological practice in China or use of evidence-based approach in Chinese hospitals. Methods: A questionnaire about doctor-reported hospital management of ACS was posted to the head of the cardiology department of 1397 hospitals across 30 provinces of China. Reported use of various clinical procedures and treatments were analysed and compared between different types of hospital. Results: Of the 1029 (74%) hospitals that responded, 43% were tier III (tertiary) hospitals. For STEMI, primary PCI was used as the main reperfusion therapy by 50.2% of tier III and 9.3% of tier II/I (secondary) hospitals. Most of hospitals also used various proven therapy routinely for STEMI and NSTEMI/UA, including anti-platelet therapy (98% and 93%), anticoagulant (96% and 90%), statin (97% and 94%), oral β-blockers (87% and 86%) and ACE-I (88% and 83%). However, certain therapies with little or no proven value (eg, G.I.K., magnesium and Chinese tradition medicine) remained used routinely by 25% - 40% of tier II/I hospitals. After discharge, statin, antiplatelet, β-blockers and ACE-I were reportedly used routinely by 85% - 95% of the responders for secondary prevention. Conclusions: With a few exceptions, doctor-reported hospital management of ACS in China is largely consistent with that recommended by current guidelines. Large nationwide registries are needed to assess long-term adherence to treatments after hospital discharge.
Reanalysis of the spectrum of the z=10 galaxy

In a recent paper Pello et al. reported observations of a faint galaxy, gravitationally lensed by the galaxy cluster Abell 1835. Deep J -band spectroscopy revealed a weak emission line near 1.34 microns, detected in two spectra with different central wavelengths. The line was interpreted as Ly α at redshift $z=10.0$. This interpretation is supported by the broad-band photometric spectral energy distribution, and by the location of the galaxy close to the lens critical line for this redshift. We have reanalysed the two spectra, just released from the data archive. Our analysis includes allowance for wavelength shifts due to transverse drift of the object in the slit. We do not detect a significant emission line at the reported location, or nearby, at either grating setting, nor in the combined spectrum. We provide a possible explanation for the reported detection as due to spurious positive flux introduced in the sky-subtraction stage as a result of variable hot pixels. We provide our final reduced 2D frame, and corresponding error array.
Polyphasic Analysis of Intraspecific Diversity in Epicoccum nigrum Warrants Reclassification into Separate Species

Background Epicoccum nigrum Link (syn. E. purpurascens Ehrenb. ex Schlecht) is a saprophytic ascomycete distributed worldwide which colonizes a myriad of substrates. This fungus has been known as a biological control agent for plant pathogens and produces a variety of secondary metabolites with important biological activities as well as biotechnological application. E. nigrum produces darkly pigmented muriform conidia on short conidiophores on sporodochia and is a genotypically and phenotypically highly variable species. Since different isolates identified as E. nigrum have been evaluated as biological control agents and used for biocompound production, it is highly desirable that this species name refers to only one lineage. However, according to morphological and genetic variation, E. nigrum present two genotypes that may comprise more than one species. Methodology/Principal Findings We report the application of combined molecular (ITS and β-tubulin gene sequence analysis, PCR-RFLP and AFLP techniques), morphometric, physiological, genetic compatibility and recombination analysis to study the taxonomic relationships within an endophytic population that has been identified as E. nigrum. This combined analysis established two genotypes showing morphological, physiological and genetic divergence as well as genetic incompatibility characterized by colony inhibition, strongly indicating that these genotypes correspond to different species. Genotype 1 corresponds to E. nigrum while genotype 2 represents a new species, referred to in this study as Epicoccum sp. Conclusions/Significance This research contributes to the knowledge of the Epicoccum genus and asserts that the classification of E. nigrum as a single variable species should be reassessed. In fact, based on the polyphasic approach we suggest the occurrence of cryptic species within E. nigrum and also that many of the sequences deposited as E. nigrum in GenBank and culture collection of microbial strains should be reclassified, including the reference strain CBS 161.73 sequenced in this work. In addition, this study provides valuable tools for differentiation of Epicoccum species.