Miracle-dz/UniFAR-FTUs huggingface dataset:
The Long Noncoding RNA HOTAIR Contributes to Cisplatin Resistance of Human Lung Adenocarcinoma Cells via downregualtion of p21WAF1/CIP1 Expression

HOTAIR, a long intervening non-coding RNA (lincRNA), associates with the Polycomb Repressive Complex 2 (PRC2) and is reported to reprogram chromatin organization and promote tumor progression. However, little is known about the roles of this gene in the development of chemoresistance phenotype of lung adenocarcinoma (LAD). Thus, we investigated the involvement of HOTAIR in the resistance of LAD cells to cisplatin. In this study, we show that HOTAIR expression was significantly upregulated in cisplatin-resistant A549/DDP cells compared with in parental A549 cells. Knockdown of HOTAIR by RNA interference could resensitize the responses of A549/DDP cells to cisplatin both in vitro and in vivo. In contrast, overexpression of HOTAIR could decrease the sensitivity of A549 and SPC-A1 cells to cisplatin. We also found that the siRNA/HOTAIR1-mediated chemosensivity enhancement was associated with inhibition of cell proliferation, induction of G0/G1 cell-cycle arrest and apoptosis enhancement through regulation of p21WAF1/CIP1 (p21) expression. Also, pcDNA/p21or siRNA/p21 could mimic the effects of siRNA/HOTAIR1 or pcDNA/HOTAIR on the sensitivity of LAD cells to cisplatin. Importantly, siRNA/p21 or pcDNA/p21 could partially rescue the effects of siRNA/HOTAIR1 or pcDNA/HOTAIR on both p21 expression and cisplatin sensitivity in LAD cells. Further, HOTAIR was observed to be significantly downregulated in cisplatin-responding LAD tissues, and its expression was inversely correlated with p21 mRNA expression. Taken together, our findings suggest that upregulation of HOTAIR contributes to the cisplatin resistance of LAD cells, at least in part, through the regulation of p21 expression.
THE DEVELOPMENT OF SCIENTIFIC-APPROACH-BASED LEARNING INSTRUMENTSINTEGRATED WITH RED ONION FARMING POTENCY IN BREBES INDONESIA

This study aimed to describe the eligibility category of science learning instrument based on scientific approach integrated with onion farming potency. Also, this study aimed to analyze the effectiveness of the application of the science learning instrument in terms ofscience process skills development and the cognitive learning outcomes in the student of class VII SMPN 1 Bulakamba.This study used thedevelopment research methods by adapting the 4D model that includes define, design, develop, and disseminate. The learning instruments developed in this research were the learning implementation plan (RPP) and the student worksheet (LKS). The data collection was done by using non-test technique using interview guides, product validation sheet, students’ response sheet to the readability of LKS and the instructional observation sheets; as well as using theworksheet of process skills and cognitive learning outcomes. The results showed that the eligibility of the science learning instruments integrated with onion farming potency was categorized as excellent. The application of scientific-approach-based learning instruments was effective to improve the process skills and the students’ cognitive learning outcomes in class VII SMPN 1 Bulakamba.
Functionalized platinum nanoparticles with surface charge trigged by pH: synthesis, characterization and stability studies

In this work, the synthesis and characterization of functionalized platinum nanoparticles (PtNPs) have been investigated. PtNPs were obtained by a wet redox procedure using 2-diethylaminoethanethiol hydrochloride (DEA) as capping agent. By varying the Pt/thiol molar ratio, monodispersed and stable particles with diameters in the range of 3–40 nm were isolated. The amino functionality allows neutral particles to be obtained in basic water solution and positive charged nanoparticles in neutral or acidic water solution (pH 7–2), as confirmed by DLS and ζ-potential measurements. FTIR spectroscopy, FE-SEM, DLS and ζ-potential measurements confirmed the size and showed long term water stability (up to three months) of the colloidal system.
Critical Factors Influencing Decision to Adopt Human Resource Information System (HRIS) in Hospitals

The aim of this research is to explore factors influencing the management decisions to adopt human resource information system (HRIS) in the hospital industry of Bangladesh—an emerging developing country. To understand this issue, this paper integrates two prominent adoption theories—Human-Organization-Technology fit (HOT-fit) model and Technology-Organization-Environment (TOE) framework. Thirteen factors under four dimensions were investigated to explore their influence on HRIS adoption decisions in hospitals. Employing non-probability sampling method, a total of 550 copies of structured questionnaires were distributed among HR executives of 92 private hospitals in Bangladesh. Among the respondents, usable questionnaires were 383 that suggesting a valid response rate of 69.63%. We classify the sample into 3 core groups based on the HRIS initial implementation, namely adopters, prospectors, and laggards. The obtained results specify 5 most critical factors i.e. IT infrastructure, top management support, IT capabilities of staff, perceived cost, and competitive pressure. Moreover, the most significant dimension is technological dimension followed by organisational, human, and environmental among the proposed 4 dimensions. Lastly, the study found existence of significant differences in all factors across different adopting groups. The study results also expose constructive proposals to researchers, hospitals, and the government to enhance the likelihood of adopting HRIS. The present study has important implications in understanding HRIS implementation in developing countries.
Comparison of estimated energy intake using Web-based Dietary Assessment Software with accelerometer-determined energy expenditure in children

Background The OPUS (Optimal well-being, development and health for Danish children through a healthy New Nordic Diet) project carried out a school meal study to assess the impact of a New Nordic Diet (NND). The random controlled trial involved 834 children aged 8–11 in nine local authority schools in Denmark. Dietary assessment was carried out using a program known as WebDASC (Web-based Dietary Assessment Software for Children) to collect data from the children. Objective To compare the energy intake (EI) of schoolchildren aged 8–11 estimated using the WebDASC system against the total energy expenditure (TEE) as derived from accelerometers worn by the children during the same period. A second objective was to evaluate the WebDASC's usability. Design Eighty-one schoolchildren took part in what was the pilot study for the OPUS project, and they recorded their total diet using WebDASC and wore an accelerometer for two periods of seven consecutive days: at baseline, when they ate their usual packed lunches and at intervention when they were served the NND. EI was estimated using WebDASC, and TEE was calculated from accelerometer-derived activity energy expenditure, basal metabolic rate, and diet-induced thermogenesis. WebDASC's usability was assessed using a questionnaire. Parents could help their children record their diet and answer the questionnaire. Results Evaluated against TEE as derived from the accelerometers worn at the same time, the WebDASC performed just as well as other traditional methods of collecting dietary data and proved both effective and acceptable with children aged 8–11, even with perhaps less familiar foods of the NND. Conclusions WebDASC is a useful method that provided a reasonably accurate measure of EI at group level when compared to TEE derived from accelerometer-determined physical activity in children. WebDASC will benefit future research in this area.
Visual Search in Medical Images

Searching is a common human activity. We search for a book in the library by looking systematically along the shelves; we search for a friend in a crowd by looking for a familiar face; we search for a pin on the floor by crawling around and feeling for the pin. The common elements in search tasks are a known object that is the purpose of the search, some knowledge about how and where the object is hidden, and a deliberate concentration on the performance of search. In technical terms, search involves a target, prior-knowledge about the target-background relationship, and selective attention. Visual search implies that the visual perceptual system is being used to conduct the search.
A Scaling Hypothesis for the Euclidean Bipartite Matching Problem

We propose a simple yet very predictive form, based on a Poisson's equation, for the functional dependence of the cost from the density of points in the Euclidean bipartite matching problem. This leads, for quadratic costs, to the analytic prediction of the large N limit of the average cost in dimension d = 1,2 and of the subleading correction in higher dimension. A nontrivial scaling exponent, γ(d) = d-2/d, which differs from the monopartite's one, is found for the subleading correction. We argue that the same scaling holds true for a generic cost exponent in dimension d > 2.
A STUDY OF STUDENT’S PROBLEMS IN DAILY ENGLISH SPEAKING ACTIVITY AT SMA POMOSDA TANJUNG ANOM NGANJUK

This research aimed at studying the student’s problems in daily English speaking activity at SMA POMOSDA Tanjunganom Nganjuk. This study tried to find the students’ problems, the causes, and the ways to cope with the problems in daily English speaking activity of this senior high school. This research was based on the fact that the students still have some problems in speaking English, although they have been encouraged to use English every day. This research was categorized as a descriptive research because the researcher wanted to describe the students’ problems in daily English speaking activity of the second grade students of SMA POMOSDA Tanjunganom Nganjuk. The population in this research was students in the second year of IPA and IPS, consisted of 112 students. The researcher took 25% from those students. The sampling technique used here was a simple random sampling. The research instruments applied were questionnaire and observation. These instruments were used to get the data of students’ problems in daily English speaking activity from different classes in the second year students. After giving and making questionnaire and observation, the researcher found that students of SMA POMOSDA Tanjunganom Nganjuk had many problems, such as: the students’ difficulty to make the sentence and difficulty to make the sentence with the correct structure. Students’ insufficient and difficulty to remember all of vocabularies used to communicate with others, students’ vernacular patois problem that gave bad effect of students’ pronunciation, intonation, accuracy, and fluency, and problem of punishment. The causes of students’ problems were because the students only had few vocabularies in their speaking and they seldom use all vocabulary in their speaking, the students only had few vocabularies and they had insufficient exercise to use the correct sentence, the students were not confident to speak with correct pronunciation, intonation, accuracy and fluency and vernacular patois which influenced their daily English speaking and students impinged regulation of language in the school. These show that students still have many problems of speaking English, although they used English in their daily activity. The students’ ways to cope with the student’s problems were the students doing more exercise and studied with the teacher and friends. The students used vocabulary in their daily communication, often did exercise with friends and studied from the book. The students learnt to pronounce the good word and studied from the book or dictionary, listened the record of native speaker, and learnt the right pronunciation and right spelling with the teacher. Finally, the students tried to increase their skill of speaking English.
BUREAU OF THE CENSUS STATISTICAL RESEARCH DIVISION REPORT SERIES SRD Research Report Number: CENSUS/SRD/RR-&l/09 ISSUES INVOLVED WITH THE SEASONAL ADJUSTMENT OF ECONOMIC TIME SERIES

In Part I of this paper we briefly review the history of seasonal adjustment and statistical time series analysis in order to understand why seasonal adjustment methods have evolved into their present form. This provides insight into some of the problems that must be addressed by seasonal adjustment procedures, and points out that advances in modern time series analysis raise the question of why seasonal adjustment should be performed at all. This leads to a discussion in Part II of issues involved in seasonal adjustment. We state our own opinions . about the issues raised and review some of the work of other authors. First, we comment on reasons that have been given for seasonal adjustment and suggest a new possible jusitification. Then we emphasize the need to precisely define the seasonal and nonseasonal components and offer our own definitions. Finally we discuss criteria for evaluating seasonal adjustments. We contend proposed criteria based upon empirical comparisons of estimated components are of little value, and suggest that seasonal adjustment methods can be evaluated based upon whether or not they are consistent with the information in the observed data. This idea is illustrated with "an example.
Drawing suspended polymer micro-/nanofibers using glass micropipettes

This letter proposes a method for fabricating suspended micro-/nanoscale polymer fibers continuously, in which polymeric micro-/nanofibers are formed by drawing and solidification of a viscous liquid polymer solution which is pumped through a glass micropipette. By controlling the drawing parameters, this method is demonstrated to form networks of suspended fibers having amorphous internal structure and uniform diameters from micrometers down to sub-50-nm for different molecular weights of polystyrene dissolved in xylene.
ADOLESCENTS' PERCEPTIONS OF STRESSORS CONTRIBUTING TO SUICIDAL BEHAVIOUR

South African adolescents show increased levels of suicidal behaviour. This article explores the perceptions of adolescents at risk of suicide regarding the psychosocial stressors they believe contribute to suicidal behaviour among South African adolescents. This study was conducted on 214 adolescents from the Western Cape Province with a high suicide risk. The group was selected on the basis of their high scores on the Suicidal Ideation Questionnaire. A qualitative content analysis was performed with their responses on a question about the reasons for adolescent suicide. The analysis highlighted risk factors relating to substance abuse, negative emotional experiences, lack of self-esteem, problem-solving ability and hope for the future; negative family environment and conflict in family relationships; peer group and romantic relationships; stressful life events; and socioeconomic factors. Guided by the Conservation of Resources (COR) theory suggestions were made for adolescent resource development to counter-act the impact of the various stressors they experience.
A person-centered exploration of children of immigrants’ social experiences and their school-based well-being

ABSTRACT This study aimed to explore commonalities among discrimination, stereotyping, and peer-related social experiences of children of immigrants, and to see if these experiences might relate to children’s school-based well-being. Two age-based cohorts of 294 children and their immigrant parents from Portugal, the Dominican Republic, and Cambodia were interviewed. Person-centered analyses resulted in four unique clusters of children’s social experiences. Notably, children in clusters with positive views of cultural in-group and out-group members also reported positive school-based well-being. Person-centered analyses on parent variables found three clusters based on parents’ ethnic/racial socialization practices. There was no overlap between parent and child clusters, indicating unique profiles between parent socialization and child social experiences within immigrant families. Implications of connections among social experiences and school-based emotional well-being for children of immigrants are discussed.
Peptide redesign for inhibition of the complement system: Targeting age-related macular degeneration

Purpose To redesign a complement-inhibiting peptide with the potential to become a therapeutic for dry and wet age-related macular degeneration (AMD). Methods We present a new potent peptide (Peptide 2) of the compstatin family. The peptide is developed by rational design, based on a mechanistic binding hypothesis, and structural and physicochemical properties derived from molecular dynamics (MD) simulation. The inhibitory activity, efficacy, and solubility of Peptide 2 are evaluated using a hemolytic assay, a human RPE cell–based assay, and ultraviolet (UV) absorption properties, respectively, and compared to the respective properties of its parent peptide (Peptide 1). Results The sequence of Peptide 2 contains an arginine-serine N-terminal extension (a characteristic of parent Peptide 1) and a novel 8-polyethylene glycol (PEG) block C-terminal extension. Peptide 2 has significantly improved aqueous solubility compared to Peptide 1 and comparable complement inhibitory activity. In addition, Peptide 2 is more efficacious in inhibiting complement activation in a cell-based model that mimics the pathobiology of dry AMD. Conclusions We have designed a new peptide analog of compstatin that combines N-terminal polar amino acid extensions and C-terminal PEGylation extensions. This peptide demonstrates significantly improved aqueous solubility and complement inhibitory efficacy, compared to the parent peptide. The new peptide overcomes the aggregation limitation for clinical translation of previous compstatin analogs and is a candidate to become a therapeutic for the treatment of AMD.
Neural network-based underwater image classification for Autonomous Underwater Vehicles

Abstract Image processing has been one of hot issues for real world robot applications such as navigation and visual servoing. In case of underwater robot application, however, conventional optical camera-based images have many limitations for real application due to visibility in turbid water, image saturation under underwater light in the deep water, and short visible range in the water. Thus, most of underwater image applications use high frequency sonar to get precise acoustic image. There have been some approaches to apply optical image processing methods to acoustic image, but performance is still not good enough for automatic classification/recognition. In this paper, a neural network-based image processing algorithm is proposed for acoustic image classification. Especially, shadow of an acoustic object is mainly used as a cue of the classification. The neural network classifies a pre-taught image from noisy and/or occlude object images. In order to get fast learning and retrieving, a Bidirectional Associative Memory (BAM) is used. It is remarked that the BAM doesn't need many learning trials, but just simple multiplication of two vectors for generating a correlation matrix. However, because of the simple calculation, it is not guaranteed to learn and recall all data set. Thus, it is needed to modify the BAM for improving its performance. In this paper, complement data set and weighted learning factor are used to improve the BAM performance. The test results show that the proposed method successfully classified 4 pre-taught object images from various underwater object images with up to 50% of B/W noise.
Kirillov–Schilling–Shimozono Bijection as Energy Functions of Crystals

The Kirillov-Schilling-Shimozono (KSS) bijection appearing in theory of the Fermionic formula gives an one-to-one correspondence between the set of elements of tensor products of the Kirillov-Reshetikhin crystals (called paths) and the set of rigged configurations. It is a generalization of Kerov-Kirillov-Reshetikhin bijection and plays inverse scattering formalism for the box-ball systems. In this paper, we give an algebraic reformulation of the KSS map from the paths to rigged configurations, using the combinatorial R and energy functions of crystals. It gives a characterization of the KSS bijection as an intrinsic property of tensor products of crystals.
Association of serum Leptin and Adiponectin with Atherosclerosis in obese and non-obese Type 2 Diabetes Mellitus patients

Obesity is a major risk factor for insulin resistance, type 2 diabetes, heart disease, and many other chronic diseases The current study was designed to investigate the endogenous mechanism by which obesity may increase the risk of CVD by examining whether serum adiponectin, Leptin or insulin mediate the association of obesity and type2 diabetes and cardiovascular risk factors in Egyptian adult patients. Patients and Methods: This study included 82 subjects, 30 patients suffering from type 2 diabetes and 52 patients suffering from type 2 diabetes together with coronary artery disease (CAD) together with another group having CAD without diabetes. They were classified according to their body mass index (BMI) into obese and non-obese groups, also 25 healthy volunteers were considered as controls. All patients were subjected to anthropometric assessment and laboratory determination of serum Adiponectin, Leptin, insulin and glucose. Insulin resistance was established by homeostasis model assessment (HOMA-IR) Differences in clinical or laboratory parameters among groups were compared by using one-way ANOVA test. Results revealed highly significant decrease in Adiponectin levels and highly significant increase in serum Leptin in non obese groups (G1 (T2D), G2 (CAD) and G3 (T2D+ CAD) as compared to controls. However, there were no statistical variations between non obese groups when compared to each others. HOMA-IR showed highly significant increase in non obese groups as compared to both controls and each other. Also, the results showed high significant decrease in Adiponectin and highly significant increase in Leptin in obese groups (G4 (T2D), G5 (CAD) and G6 (T2D+CAD) when compared to controls. However, there were no statistical variations between obese groups when compared to each others as regard Adiponectin, while Leptin showed statistical increase between (G4) and (G5) groups when compared to each others, HOMA-IR showed highly significant increase in the two obese groups only (G4 and G6) as compared to controls, while there was no significant variation in (G5) when compared to controls. Moreover, there was a significant increase in all obese groups when compared to each other. Also, there was significant correlation between serum Adiponectin and Leptin in obese DM patients. Conclusion: The coexistence of correlation between serum leptin and Adiponectin levels in addition to increase of serum leptin and decrease serum Adiponectin levels in obese DM patients in the current study; support the hypothesis of their susceptibility to atherosclerosis. (Journal of American Science 2010;6(5):153- 164). (ISSN: 1545-1003).