Miracle-dz/UniFAR-FTUs huggingface dataset:
Children with type 1-diabetes from ethnic minorities: vulnerable patients needing a tailored medical support.

BACKGROUND AND AIM Newly diagnosed children with type 1 diabetes from ethnic minorities are a growing presence in outpatient pediatric clinics, and are reported as a group at risk of poor metabolic control. In the present study we investigated the barriers affecting chances of minority diabetic children to achieve the same metabolic targets of native peers with type 1 diabetes. MATERIALS AND METHODS The study investigated 35 children from ethnic minorities (group 1) admitted to the Children University Hospital of Parma, Italy, from 1st January 2000 to December 31st, 2011, and data concerning current age, gender, ethnicity, age at diabetes onset, HbA1c, DKA severity degree at diagnosis, insulin therapy, annual number of out patient clinic visits, number of admissions for acute decompensation, and treatment cost. A short questionnaire on background, family situation, difficulties in diabetes monitoring, and outpatient clinic procedures completed the study. The results were compared with data collected from 30 matched native peers (group 2). RESULTS Mean HbA1c level at admittance was higher in Group 1 (11.8 +/- 1.0%) than in Group 2 (9.0 +/- 2.2%; p=0.000). The differences were confirmed when HbAlc mean cumulative values (8.6 +/- 2.1 vs 7.6 +/- 1.1; p=0.022) were calculated. Group 1 children at admission showed poorer metabolic conditions and longer stay at hospital (16 +/- 3 days) than Group 2 patients (8 +/- 2 days; p=0.000). The total costs for DKA treatment and family education resulted higher in group 1 (+54%) than in group 2 patients. Discontinuous capillary blood glucose monitoring and outpatient clinic visits missed were more frequent in Group 1 than in group 2 patients. Thirteen patients in group 1 needed a re-admittance to hospital because of a hypoglycemia (5 cases) or a hyperglycemia (8 cases). The same episodes were not recorded in group 2 patients. Most of parents expressed the wish to be supported with educational material in their own language. CONCLUSIONS Children with TDM belonging to an ethnic minority had poorer metabolic control compared with native patients. This results from several cultural, educational, economic deficiencies which influence their family life and probably reduced their chances to obtain a better control.
Star Formation Rates and Extinction Properties of IR-luminous Galaxies in the Spitzer First Look Survey

We investigate the instantaneous star formation rates (SFRs) and extinction properties for a large (N = 274), near-infrared (NIR: 2.2 μm) + mid-infrared (MIR: 24 μm)-selected sample of normal to ultraluminous infrared galaxies (ULIRGs; 109 < LIR/L☉ < 1012.5) with ⟨z⟩ ~ 0.8 in the Spitzer Extragalactic First Look Survey (FLS). We combine 24 μm observations with high-resolution Keck DEIMOS spectroscopy to derive optical emission-line (Hα, Hβ, and [O II]) and infrared star formation rates (SFRopt and SFRIR, respectively). Comparison of SFR diagnostics reveals a wide extinction range (1.0 < AV < 4.0 mag) for this sample, even after removing spectroscopic and IRAC color-selected AGN candidates (≈12% of the sample). Objects with SFRs of a few M☉ yr-1 have extinction values consistent with normal spirals (AV ≈ 1.0 mag). By contrast, LIRGs at z ≳ 1, which comprise a fraction of our sample, have SFR ≈ 100 M☉ yr-1 and a mean AV ≈ 2.5 mag. This translates to a 97% mean [O II] λλ3727 attentuation and in extreme cases is as high as 99.7%. We derive an IR-luminosity-dependent A function [A = 0.75 log(LIR/L☉) - 6.35 mag] that we use to extinction correct our line luminosities. The resulting correlation between SFRIR and SFRopt has a dispersion of ~0.2 dex (semi-interquartile range). Comparison of the AV dependence on redshift and LIR reveals that for a fixed LIR, there is no significant AV evolution. Comparison to previous studies reveals a mean attenuation that is intermediate between that of local optical/UV- and radio-selected samples with a marginally stronger LIR dependence.
The relationship between empathy and burnout – lessons for paramedics: a scoping review

Background The concepts of empathy and burnout are critical for practicing paramedics and the profession. While there has been an increasing body of research on the relationship between empathy and burnout with physicians and nurses, surprisingly, no research has been undertaken with paramedics. The aim of this scoping review was to explore the relationship between empathy and burnout. Method A scoping review was performed based on Arskey and O’Malley’s framework. Five databases were searched: CINAHL plus, EMBASE, MEDLINE, PsycINFO, and Scopus. Google Scholar was searched for gray literature. Two reviewers independently assessed eligibility and extracted the data. Results The initial search produced a yield of 1270 articles after removal of duplicates. All abstracts were screened for relevance, and 30 articles were selected for further screening. Twenty six articles were deemed relevant, of which there were 23 cross-sectional studies, two editorials, and one description article on the multidimensional aspect of burnout and empathy. The studies were conducted in Europe, USA, North America, and Asia. In most studies, there was an inverse correlation between empathy and emotional exhaustion and depersonalization but a positive correlation with personal accomplishment. Conclusion Although there seems to be a real relationship between empathy and burnout in physicians and nurses, the strength of the relationship differs to some extent depending on the samples and settings. Due to similarities between health professions, the relationship between empathy and burnout may also be relevant to the paramedic profession. Future paramedic research should focus on longitudinal studies to determine the factors that might influence empathy and burnout levels to provide a better understanding of these two key factors.
''Masked'' Span of Apprehension in Schizophrenic Subgroups

Background. This study explored the possible impairment in inhibiting irrelevant stimuli (as reflected in the backward masking version of the forced-choice span of apprehension task) in subgroups of individuals with schizophrenia. Method. Subjects included 48 schizophrenics and 54 nonpsychiatric controls. Letter arrays were presented at three stimulus onset asynchronies (SOAs; 60, 100, 250msec) and three levels of complexity (3, 7, 11 distractor letters). Results. As a group, schizophrenics (n = 54) were impaired relative to nonpsychiatric controls (n = 48) for 7-distractor displays at 60msec and 250msec SOA. Cluster analysis of SAPS and SANS ratings produced four symptom subgroups. Opposing masking performances were found for Psychomotor Poverty (impaired for long SOAs) and Reality Distortion (enhanced at short SOAs) subgroups, whereas the Disorganisation subgroup was globally impaired, and the Episodic subgroup performed similarly overall to controls. Conclusion. The results highlight the potential importance of symptomatology in further elucidating the span of apprehension impairment in schizophrenia.
Factors Contributing to Teachers’ Sustained Use of Kindergarten Peer-Assisted Learning Strategies

Abstract Factors were explored that predicted whether teachers sustained the use of a validated reading intervention. Seventy-three teachers from 37 schools in 3 states were asked in interviews whether they continued to use Kindergarten Peer Assisted Learning Strategies (KPALS) 1 year after their involvement in the program. A logistic regression model was created with teachers’ yes/no responses as the dependent variable and with predictors identified as important to sustainability. Findings were consonant with current theoretical models of sustainability. The logistic regression model captured many key elements of teachers’ decisions to sustain. Strongest predictors were teacher perceptions of the effectiveness of KPALS and degree of external technical support given them.
Identification and classification of Lactobacillus acidophilus, L. gasseri and L. johnsonii strains by SDS-PAGE and rRNA-targeted oligonucleotide probe hybridization.

Thirty-two strains originally identified as Lactobacillus acidophilus and L. gasseri were screened for their taxonomic homogeneity by SDS-PAGE of whole-cell proteins. After numerical comparison of the resulting protein electrophoretic fingerprints, two well-delineated clusters were detected. The majority of the strains grouped in one electrophoretic cluster, which contained the type strain of L. acidophilus and corresponds to DNA group A1 of Johnson, J. L. , Phelps, C. F. , Cummins, C. S. , London, J. & Gasser, F. (1980; International Journal of Systematic Bacteriology 30, 53-68). Another cluster corresponded to DNA group B. It contained two subclusters, which agreed perfectly with DNA subgroups B1 (L. gasseri) and B2 (L. johnsonii), respectively. The 23S rRNA genes were partially sequenced and 23S-rRNA-targeted oligonucleotide probes were designed for identification of DNA groups A1, B1 and B2. Probe Lbg reacted with all strains of electrophoretic cluster B1 (L. gasseri), probe Lbj hybridized with strains of cluster B2 (L. johnsonii) and probe Lba with strains of cluster A1 (authentic L. acidophilus). The probes were successfully used for the identification of strains belonging to the respective species. The phylogenetic relationship of a representative of L. johnsonii was determined by comparative sequence analysis of the 16S rRNA genes. It is very closely related to L. gasseri.
Clinico-pathological studies of Plasmodium falciparum and Plasmodium vivax — malaria in India and Saudi Arabia

Malaria is one of the most devastating diseases of tropical countries with clinical manifestations such as anaemia, splenomegaly, thrombocytopenia, hepatomegaly and acute renal failures. In this study, cases of thrombocytopenia and haemoglobinemia were more prominent in subjects infected with Plasmodium falciparum (Welch, 1897) than those with Plasmodium vivax (Grassi et Feletti, 1890). However, anaemia, jaundice, convulsions and acute renal failure were significantly high (3–4 times) in subjects infected with P. falciparum than those infected with P. vivax. The incidence of splenomegaly and neurological sequelae were 2 and 6 times higher in P. falciparum infections compared to the infections of P. vivax. Both in P. vivax and P. falciparum malaria, the cases of splenomegaly, jaundice and neurological sequelae were almost double in children (<10 years) compared to older patients. The liver enzymes were generally in normal range in cases of low and mild infections. However, the AST, ALT, ALP activities and serum bilirubin, creatinine, and the urea content were increased in P. falciparum and P. vivax malaria patients having high parasitaemia, confirming liver dysfunction and renal failures in few cases of severe malaria both in India and Saudi Arabia.
Effective Mass Anomalies in Strained-Si Thin Films and Crystals

Using first-principles calculations, effective mass for silicon channel region is investigated as a function of strain and substrate thickness. In {111} and {110} biaxially strained-Si, it is found that the longitudinal effective mass is extraordinarily enhanced for both thin films and crystals. This mass enhancement is caused by the change of the band structure with double minima into that with a single minimum due to strain and confinement. It is analytically shown that the effective mass diverges at the transition point. Further, we suggest the parameter regions of the strain, thickness, and confinement direction, which are most suitable for the experimental observation of the anomalies.
Inhibition of nucleolar reformation after microinjection of antibodies to RNA polymerase I into mitotic cells

The formation of daughter nuclei and the reformation of nucleolar structures was studied after microinjection of antibodies to RNA polymerase I into dividing cultured cells (PtK2). The fate of several nucleolar proteins representing the three main structural subcomponents of the nucleolus was examined by immunofluorescence and electron microscopy. The results show that the RNA polymerase I antibodies do not interfere with normal mitotic progression or the early steps of nucleologenesis, i.e., the aggregation of nucleolar material into prenucleolar bodies. However, they inhibit the telophasic coalescence of the prenucleolar bodies into the chromosomal nucleolar organizer regions, thus preventing the formation of new nucleoli. These prenucleolar bodies show a fibrillar organization that also compositionally resembles the dense fibrillar component of interphase nucleoli. We conclude that during normal nucleologenesis the dense fibrillar component forms from preformed entities around nucleolar organizer regions, and that this association seems to be dependent on the presence of an active form of RNA polymerase I.
CD40 ligation during dendritic cell maturation reduces cell death and prevents interleukin‐10‐induced regression to macrophage‐like monocytes

Abstract: Dendritic cells (DCs) have become popular candidates in cancer vaccination because of their crucial role in inducing T‐cell responses. However, clinical studies greatly differ in their protocols for generating DCs and the efficacy in treating established tumors needs to be improved. We systematically analyzed DCs maturated by five different protocols for surface markers, the alloproliferative T‐cell response, the DC survival after cytokine deprivation, the stability of surface markers under the influence of interleukin‐10 (IL‐10) and the DC cytokine secretion pattern. Monocyte‐derived DCs were maturated by CD40‐ligand (CD40‐L), unmethylated cytosine–guanosine dinucleotides‐oligodinucleotides (CpG‐ODN), an inflammatory cytokine cocktail (ICC), a combination of ICC and CD40‐L, or ICC, CD40‐L and CpG‐ODN. A high co‐expression of DC maturation and costimulation markers was found after treatment with ICC plus CD40‐L (69.3 ± 9.6% CD83/CD80 double positive staining) and correlated with a significantly increased cell survival, a high expression of the antiapoptotic factor bcl‐XL, a stable CD83high/CD14low expression under the influence of IL‐10, and a strong alloproliferative T‐cell response. In conclusion, our data support the use of maturation protocols containing ICC plus CD40‐L in order to generate highly mature, phenotypically stable, cell‐death resistant, and T‐cell stimulatory DCs for clinical application in cancer patients.
Data-Flow Analysis for Multi-Core Computing Systems: A Reminder to Reverse Data-Flow Analysis

The increasing demands for highly performant, proven correct, easily maintainable, extensible programs together with the continuous growth of real-world programs strengthen the pressure for powerful and scalable program analyses for program development and code generation. Multi-core computing systems offer new chances for enhancing the scalability of program analyses, if the additional computing power offered by these systems can be used effectively. This, however, poses new challenges on the analysis side. In principle, it requires program analyses which can be easily parallelized and mapped to multi-core architectures. In this paper we remind to reverse data-flow analysis, which has been introduced and investigated in the context of demand-driven data-flow analysis, as one such class of program analyses which is particularly suitable for this.
Gender Justice in Advertisements: Study of Indian Commercials

Television commercials have more to convey than any other media of communication in the present day scenario. Very short, straight yet creative messages are conveyed to the target audience with a messenger. To convey any message women are used irrespective of the fact that they are the part of the product or utility. However, the stereotyped notions still get reflected even in the modern societies especially with respect to women. This paper analyses the select cases of Indian commercials with the content analysis from gender sensitivity perspective. It is an attempt of qualitative analysis along with the recent debates and reactions from the institutional perspective.
Influence of Selected Patient Variables and Operative Blood Loss on Six-Month Survival Following Liver Transplantation

A group of 118 adults who underwent primary, orthotopic transplantation of the liver over a 4-year period served as the subjects of a detailed examination of their ability to survive the first 6 months as a function of their preoperative condition. As a result, a scoring system was developed empirically in an attempt to separate very high-risk from relatively low-risk patients. The scoring method is based on the high degree of correlation between survival probability and various patient characteristics. It allows for additional scoring to account for the dramatic effect of operative blood loss on the eventual outcome. The curve that best describes the relationship between patient scores and survival probability is sigmoidal in shape. Many patients will have scores located on the curve between the inflection points. They represent a group whose relative risk is difficult to estimate but for whom operative blood loss or the occurrence of surgical complications may prove particularly telling.
Social Exclusion, Mobility and Access 1

Much of the literature on social exclusion ignores its ‘spatial’ or ‘mobility’ related aspects. This paper seeks to rectify this by examining the mobile processes and infrastructures of travel and transport that engender and reinforce social exclusion in contemporary societies. To the extent to which this issue is addressed, it is mainly organized around the notion of ‘access’ to activities, values and goods. This paper examines this discourse in some detail. It is argued that there are many dimensions of such access, that improving access is a complex matter because of the range of human activities that might need to be ‘accessed’, that in order to know what is to be accessed the changing nature of travel and communications requires examination, and that some dimensions of access are only revealed through changes in the infrastructure that ‘uncover’ previously hidden social exclusions. Claims about access and socio-spatial exclusion routinely make assumptions about what it is to participate effectively in society. We turn this question around, also asking how mobilities of different forms constitute societal values and sets of relations, participation in which may become important for social inclusion. This paper draws upon an extensive range of library, desk and field research to deal with crucial issues relating to the nature of a fair, just and mobile society.
Hypothermia Promotes Interleukin-22 Expression and Fine-Tunes Its Biological Activity

Disturbed homeostasis as a result of tissue stress can provoke leukocyte responses enabling recovery. Since mild hypothermia displays specific clinically relevant tissue-protective properties and interleukin (IL)-22 promotes healing at host/environment interfaces, effects of lowered ambient temperature on IL-22 were studied. We demonstrate that a 5-h exposure of endotoxemic mice to 4°C reduces body temperature by 5.0° and enhances splenic and colonic il22 gene expression. In contrast, tumor necrosis factor-α and IL-17A were not increased. In vivo data on IL-22 were corroborated using murine splenocytes and human peripheral blood mononuclear cells (PBMC) cultured upon 33°C and polyclonal T cell activation. Upregulation by mild hypothermia of largely T-cell-derived IL-22 in PBMC required monocytes and associated with enhanced nuclear T-cell nuclear factor of activated T cells (NFAT)-c2. Notably, NFAT antagonism by cyclosporin A or FK506 impaired IL-22 upregulation at normothermia and entirely prevented its enhanced expression upon hypothermic culture conditions. Data suggest that intact NFAT signaling is required for efficient IL-22 induction upon normothermic and hypothermic conditions. Hypothermia furthermore boosted early signal transducer and activator of transcription 3 activation by IL-22 and shaped downstream gene expression in epithelial-like cells. Altogether, data indicate that hypothermia supports and fine-tunes IL-22 production/action, which may contribute to regulatory properties of low ambient temperature.
Processing of Hand-Related Verbs Specifically Affects the Planning and Execution of Arm Reaching Movements

Even though a growing body of research has shown that the processing of action language affects the planning and execution of motor acts, several aspects of this interaction are still hotly debated. The directionality (i.e. does understanding action-related language induce a facilitation or an interference with the corresponding action? ), the time course, and the nature of the interaction (i.e. under what conditions does the phenomenon occur? ) are largely unclear. To further explore this topic we exploited a go/no-go paradigm in which healthy participants were required to perform arm reaching movements toward a target when verbs expressing either hand or foot actions were shown, and to refrain from moving when abstract verbs were presented. We found that reaction times (RT) and percentages of errors increased when the verb involved the same effector used to give the response. This interference occurred very early, when the interval between verb presentation and the delivery of the go signal was 50 ms, and could be elicited until this delay was about 600 ms. In addition, RTs were faster when subjects used the right arm than when they used the left arm, suggesting that action–verb understanding is left-lateralized. Furthermore, when the color of the printed verb and not its meaning was the cue for movement execution the differences between RTs and error percentages between verb categories disappeared, unequivocally indicating that the phenomenon occurs only when the semantic content of a verb has to be retrieved. These results are compatible with the theory of embodied language, which hypothesizes that comprehending verbal descriptions of actions relies on an internal simulation of the sensory–motor experience of the action, and provide a new and detailed view of the interplay between action language and motor acts.
Evaluation of radiographers’ mammography screen-reading accuracy in Australia

This study aimed to evaluate the accuracy of radiographers’ screen‐reading mammograms. Currently, radiologist workforce shortages may be compromising the BreastScreen Australia screening program goal to detect early breast cancer. The solution to a similar problem in the United Kingdom has successfully encouraged radiographers to take on the role as one of two screen‐readers. Prior to consideration of this strategy in Australia, educational and experiential differences between radiographers in the United Kingdom and Australia emphasise the need for an investigation of Australian radiographers’ screen‐reading accuracy.