Miracle-dz/UniFAR-FTUs huggingface dataset:
Interplay between Intravitreal RvD1 and Local Endogenous Sirtuin-1 in the Protection from Endotoxin-Induced Uveitis in Rats

Rat endotoxin-induced uveitis (EIU) is a well-established model of human uveitis. In this model, intravitreal injection of resolvin D1 (RvD1, 10–100–1000 ng/kg) 1 hour after subcutaneous treatment of Sprague-Dawley rats with lipopolysaccharide (LPS, 200 μg/rat) significantly prevented the development of uveitis into the eye. RvD1 dose-dependently increased the expression of sirtuin-1 (SIRT1) within the eye, while it decreased the expression of acetyl-p53 and acetyl-FOXO1. These effects were accompanied by local downregulation of some microRNAs related to the expression and activity of SIRT1. These were miR-195-5p, miR-200a-3p, miR-34a-5p, and miR-145-5p. An increase of manganese superoxide dismutase and decrease of caspase 3 were evident after RvD1 treatment. In another set of experiments, the protective effects of RvD1 (1000 ng/kg) were partly abolished by the pretreatment of the rats with EX527 (10 mg/kg/day, i.p.), a specific inhibitor of SIRT1 activity, for 7 days prior to the induction of EIU in rats. Similarly, the effects of RvD1 (1000 ng/kg) on the SIRT1 protein expression were abolished by Boc2, N-t-butoxycarbonyl-PLPLP, a specific formyl-peptide receptor type 2/lipoxin A receptor antagonist. Therefore, an interplay of the SIRT1 activity on the RvD1 mediated resolution of EIU is argued.
Cross-company and single-company effort models using the ISBSG database: a further replicated study

Five years ago the ISBSG database was used by Jeffery et al. [6] (S1) to compare the effort prediction accuracy between cross- and single-company effort models. Given that more than 2,000 projects were later volunteered to this database, in 2005 Mendes et al. [17] (S2) replicated S1 but obtained different results. The difference in results between both studies could have resulted from legitimate differences in data set patterns but also could have been influenced by differences in experimental procedure. S2 was unable to employ exactly the same experimental procedure used in S1, as S1's procedure was not fully documented. Therefore this paper aimed to apply S2's experimental procedure to the ISBSG database version used in S1 (release 6) to assess if differences in experimental procedure would have contributed towards different results. Our results corroborated those from S1: we found that predictions based on a single-company model were significantly more accurate than those based on a cross-company model.
Bone Health in Athletes

Context: The health of the skeletal system is important for athletes young and old. From the early benefits of exercise on bones to the importance of osteoporosis prevention and treatment, bone health affects the ability to be active throughout life. Evidence Acquisition: PubMed articles dating from 1986 to 2016 were used for the review. Relevant terms such as keywords and section titles of the article were searched and articles identified were reviewed for relevance to this article. Study Design: Clinical review. Level of Evidence: Levels 1 through 4 evidence included. Results: There is strong evidence that exercise benefits bone health at every age and is a critical factor in osteoporosis prevention and treatment. Vitamin D, calcium, and hormones play vital roles in ensuring optimal bone health. When there is an imbalance between exercise and nutrition, as seen in the female athlete triad, bone health is compromised and can lead to bone stress injuries and early osteoporosis. Both of these can lead to morbidity and lost time from training and competition. Thus, early recognition and appropriate treatment of the female athlete triad and other stress fracture risk factors are vital to preventing long-term bone health problems. Conclusion: To optimize bone health, adequate nutrition, appropriate weightbearing exercise, strength training, and adequate calcium and vitamin D are necessary throughout life.
Exposure to Science is Not Enough: The Influence of Classroom Experiences on Belief in Paranormal Phenomena

Beliefs in scientifically unsubstantiated ideas were investigated with a study that contrasted college students' attitudes toward paranormal phenomena before and after exposure to skeptical arguments concerning these events. Specifically, students enrolled in 2 sections of a psychological statistics course were exposed to illustrations of statistical concepts that were either paranormal-themed or not, with a 3rd group of participants completing a class that focused on the critical analysis of believer- and skeptic-based ideas surrounding paranormal phenomena. Results revealed that skepticism increased, over time, only when direct exposure to paranormal phenomena was included in one's course work. Results are discussed in terms of the educational and societal implications for encouraging skepticism of scientifically questionable claims.
The Return of the Myth of the Mental

McDowell's claim that “in mature human beings, embodied coping is permeated with mindedness”,1 suggests a new version of the mentalist myth which, like the others, is untrue to the phenomenon. The phenomena show that embodied skills, when we are fully absorbed in enacting them, have a kind of non‐mental content that is non‐conceptual, non‐propositional, non‐rational and non‐linguistic. This is not to deny that we can monitor our activity while performing it. For solving problems, learning a new skill, receiving coaching, and so forth, such monitoring is invaluable. But monitoring what we are doing as we are doing it degrades performance to at best competence. On McDowell's view, there is no way to account for such a degradation in performance since the same sort of content would be involved whether we were fully absorbed in or paying attention to what we were doing. McDowell claims that it is an advantage of his conceptualism that it avoids any foundationalist attempt to build up the objective world on the basis of an indubitable Given or any other ground‐floor experience. And, indeed, if the world is all that is the case and our minds are unproblematically open to it, all experience is on the same footing. But one must distinguish motor intentionality, and the interrelated solicitations our coping body is intertwined with, from conceptual intentionality and the world of propositional structures it opens onto. The existential phenomenologist can then agree with McDowell in rejecting traditional foundationalisms, while yet affirming and describing the ground‐floor role of motor intentionality in providing the support on which all forms of conceptual intentionality are based. *. As presented at the Eastern Division Meeting of the American Philosophical Association, Washington DC, December 29, 2006.
Factors associated with dietary patterns among low-income adults

Abstract Objective To describe the association of socio-economic, demographic and lifestyle characteristics with three eating patterns identified among low-income adults living in the Rio de Janeiro metropolitan area, Brazil. Design Data were obtained in a population-based cross-sectional study. The analysed patterns were: (i) ‘Mixed’, in which diverse foods had similar factor loadings; (ii) ‘Western’, which included items with high energy density; and (iii) ‘Traditional’, which relied in rice and beans, traditional staple foods in Brazil. Hierarchical logistic analysis was performed to estimate the association between the independent variables and each one of the dietary patterns. The variables that presented statistical significance <0·20 in the univariate analysis (χ2 test) were included in the multivariate models. Setting Duque de Caxias, a low-income area in the Rio de Janeiro metropolitan region, Brazil. Subjects Adults (n 1009) aged 20 to 65 years (339 men and 670 women). Results The ‘Mixed’ pattern was positively associated with smoking (OR = 1·58, 95 % CI 1·00, 2·48 for current smoking v. those who never smoked). The ‘Western’ pattern was positively associated with family income (OR = 3·00, 95 % CI 1·81, 4·97 for those with monthly per capita family income ≥1·0 v. <0·5 times the official Brazilian minimum wage) and inversely associated with family food insecurity (OR = 0·55, 95 % CI 0·36, 0·84). The ‘Traditional’ pattern was associated with family food insecurity (OR = 1·79, 95 % CI 1·27, 2·51). Conclusions The results support previous findings relating improvement in economic conditions to reduced adherence to the traditional Brazilian food consumption pattern based on the combination of rice and beans.
A clinical assessment of mycophenolate drug monitoring after liver transplantation

Hwang S, Lee S‐G, Ahn C‐S, Kim K‐H, Moon D‐B, Ha T‐Y, Song G‐W, Jung D‐H, Choi N‐K, Kim K‐W, Yu Y‐D, Park G‐C, Park P‐J, Choi Y‐I. A clinical assessment of mycophenolate drug monitoring after liver transplantation. Clin Transplant 2010 DOI: 10.1111/j.1399‐0012.2009. 01166.x © 2010 John Wiley & Sons A/S.
Diabetic versus non-diabetic colour vision after cataract surgery

AIMS To examine whether the colour vision abnormalities found in phakic patients with diabetes mellitus is preserved after removal of the lens by cataract surgery. METHODS 21 diabetic (16 IDDM and five NIDDM) and 19 non-diabetic patients of comparable age, postoperative visual acuity, and sex distribution, all aphakic or pseudophakic following cataract surgery, had their monocular colour vision examined using the Farnsworth-Munsell 100 hue test. The fundus status of the diabetic patients ranged from no retinopathy to photocoagulation treated proliferative diabetic retinopathy. Patients with macular oedema were specifically excluded from the study. RESULTS The error scores of both the diabetic (mean 146 (SD 94)) and the non-diabetic patients (83 (79)) did not deviate significantly from the age related normal range. The error score in the diabetic group was significantly higher than in the non-diabetic group (p=0.02) but the amplitude of the difference was small in comparison with previous studies of phakic subjects. The error scores in the diabetic group were not correlated with the degree of retinopathy (p>0.2). CONCLUSION After cataract surgery only a minor difference exists between the colour vision scores of diabetic and non-diabetic patients. This indicates that accelerated yellowing of the lens in diabetes is the predominant cause of the colour vision anomaly found in phakic diabetic patients.
Binary and Millisecond Pulsars at the New Millennium

We review the properties and applications of binary and millisecond pulsars. Our knowledge of these exciting objects has greatly increased in recent years, mainly due to successful surveys which have brought the known pulsar population to over 1300. There are now 56 binary and millisecond pulsars in the Galactic disk and a further 47 in globular clusters. This review is concerned primarily with the results and spin-offs from these surveys which are of particular interest to the relativity community.
International talent flow and intention to repatriate: an identity explanation

Using a sample of 563 Australian professionals currently working overseas, we investigate the relationships between intention to repatriate and national identity, demographic variables, quality of life, career advancement, personal networks, social context, and situational characteristics. Our findings show that national identity, length of time already spent overseas, quality of life available in the home country, employment in a multinational enterprise (MNE) and expatriate location were predictive of intention to repatriate to Australia. This research has implications for individuals, employers and government policy with regard to the management of talent flows of skilled workers.
In Their Own Words: Addicts' Reasons for Initiating and Withdrawing from Heroin

Samples were drawn from each of three narcotic addict-client populations: adult male addicts (N=105), adult female addicts (N = 36), and juvenile male addicts (N = 77). Each person was given a structured interview containing questions regarding his initial use of heroin, his efforts at withdrawal, his initial criminal act, and selected items of demographic information. The findings indicated that addicts, particularly juvenile addicts, are encouraged to begin using heroin by friends in their communities, but the impetus to stop using heroin must come largely from within the self with little support available in the community. Moreover, the treatment program must expect to contend with the addict's own ambivalence about giving up drugs. On the one hand, he feels a very genuine dissatisfaction with the addict-criminal life style and, on the other hand, he feels a continuing psychological hunger for the drug.It was also found that illegal activity by these male street-visible addicts—and indeed arrests of th.
Treatment of incest and pedophilic offenders: A pilot study

Twenty-nine incest and 22 heterosexual pedophilic offenders, under sentence, participated in a study of therapeutic outcome. RESULTS showed the two groups were remarkably similar in their pretreatment level of psychosocial functioning. However, pedophiles had a significantly higher recidivism rate than incestuous men. Incest offenders, on the whole, changed most relative to single or married pedophiles. Pedophiles appeared more treatment resistant in dealing with their disturbed family relations, verbal hostility, irritability, and feelings of anger that, in part, underlie their sexual anomaly. At follow-up 36 months later, only 2 incest and 4 pedophilic men had recidivated. The discussion links these findings with earlier research and proposes a multimodal, group-oriented approach to treating sex offenders. Language: en
Young People,Time Horizons and Planning

In a recent article in Sociology, Anderson et al. (2005) explore the plans Scottish young adults formulated for their future lives, drawing largely on survey evidence. They do so in the context of taking issue with qualitative research conducted by Brannen and Nilsen (2002) concerning how British young people and young Norwegians think about the future.This article compares the respective studies in greater depth. First, it examines the different aims of the respective studies and their conceptualizations. Second, it looks at issues of methodological difference.
Jet Physics of Accreting Super-Massive Black Holes in the Era of the Fermi Gamma-ray Space Telescope

The Fermi Gamma-ray Space Telescope with its main instrument on-board, the Large Area Telescope (LAT), opened a new era in the study of high-energy emission from Active Galactic Nuclei (AGN). When combined with contemporaneous ground- and space-based observations, Fermi-LAT achieves its full capability to characterize the jet structure and the emission mechanisms at work in radio-loud AGN with different black hole mass and accretion rate, from flat spectrum radio quasars to narrow-line Seyfert 1 (NLSy1) galaxies. Here, I discuss important findings regarding the blazar population included in the third LAT catalog of AGN and the gamma-ray emitting NLSy1. Moreover, the detection of blazars at redshift beyond three in gamma rays allows us to constrain the growth and evolution of heavy black holes over cosmic time, suggesting that the radio-loud phase may be important for a fast black hole growth in the early Universe. Finally, results on extragalactic objects from the third catalog of hard LAT sources are presented.
Intense pulsed light in the treatment of non‐aesthetic facial and neck vascular lesions: report of 85 cases

Background Intense pulsed light (IPL) treatment is one of the most effective procedures for patients with non‐aesthetic vascular lesions in addition to signs of skin photoageing, and it has been reported as very successful in the treatment of telangiectasias, spider nevi, erythrosis, and above all, rosacea and poikiloderma. Its use is based on the principle of selective photothermolysis, which exploits the haemoglobin absorption peak among its range of wavelengths.
Using action research to address the mental health needs of older people: a reflection and discussion of real‐world problems

Action research provides an opportunity to implement and understand the process of change in practice settings, as well as develop theoretical insights into complex social situations. The provision of mental healthcare for older people within the general hospital is one such situation, and this paper presents a discussion and reflection on the use of action research in this setting. The background to the project is described, followed by a discussion of three major issues that emerged for us: the extent to which we were able to promote democracy and maintain and demonstrate democratic behaviour, the problems and pitfalls of operationalising grounded theory methodology within an action research approach, and the challenges of developing an authentic and credible account of the care of older people with mental health needs. This paper aims to add to a discourse regarding action research and will be of value to researchers using this approach across a range of health, social care and educational settings.
High Ability/Learning Disabled Students: How Are They Different?

The purpose of the research was to investigate what characteristics distinguish High Ability/LD students from learning disabled students with average cognitive ability and from high ability students. One hundred-twelve high ability or learning disabled students in grades four through six participated in the study: High Ability, High Ability/LD, and LD/Average. A variety of instruments was used to assess and compare cognitive and motivational patterns in the three groups. Discriminant analyses indicated that the three groups are distinguishable. As might be expected, the greatest group difference existed between high ability nondisabled students and both learning disabled populations. A second discriminant function provided information about differences between the two learning disabled populations.
Principals and the professional learning community: learning to mobilize knowledge

Purpose – The purpose of this paper is to use the Objective Knowledge Growth Framework (OKGF) in the development and maintenance of the Canadian Principal Learning Network (CPLN) to advance principals’ knowledge and skills in the area of decision making. First, the paper presents the inception of the CPLN, to assist principals in making decisions and resolving common problems. Second, the evolution of the CPLN web site is presented and recount the challenges faced and collaborative solved by principals. Finally, the paper describes the OKGF based on the critical rationalism of Karl Popper and how principals, engaging and interacting in an online learning community (CPLN) informed their decision-making process. Design/methodology/approach – The paper mindfully assembled an international team of researchers with administration experience, curriculum knowledge and pedagogy, and whose research interests lay in educational leadership, education administration, change theory, educational policy and professional.
Assessment by a multidisciplinary clinical nutrition team before percutaneous endoscopic gastrostomy placement reduces early postprocedure mortality.

BACKGROUND The purpose of this study was to determine whether preassessment by a multidisciplinary nutrition team before percutaneous endoscopic gastrostomy (PEG) placement can reduce postprocedure mortality. This was a prospective single-center audit. METHODS Patients who had been referred to the Gastroenterology Department for consideration of PEG placement between 1995 and 2004 were included. In the index year, 2003-2004, where a formal nutrition team assessment was commenced, 79 patients were enrolled into our study group on a consecutive basis. These patients were subdivided into 3 groups; group A, PEG placed (51 patients); group B, PEG not placed due to severe comorbidity (19 patients); and group C, PEG not placed as deemed unnecessary (9 patients). Comparison was made with previous years where no formal preassessment had occurred. At Staffordshire General Hospital, a comparison of mortality post-PEG placement was made between the index group and previous years. Secondary measures included complication rates and frequency of biochemical monitoring. RESULTS One week post-PEG mortality fell from 10%-20% in previous years to 0% in the index year (p < .02). This improved survival extended to 3 months postprocedure (p < .016). Three patients (6%) had biochemical evidence of refeeding syndrome postplacement. Biochemical monitoring was inadequate, with only 27/51 (53%) patients being completely monitored. No complications pertaining to the endoscopy were reported. CONCLUSIONS This study demonstrates that early post-PEG mortality can be reduced by preassessment of patients by a multidisciplinary nutrition team and is evidence supporting the recommendations of the National Confidential Enquiry into Patient Outcome and Death report.
Turbulent Energy Decay Along the Path of Least Action

A fluctuation law of the energy in freely-decaying, homogeneous and isotropic turbulence is derived within a Gaussian closure ansatz for 3D incompressible flow. In particular, a fluctuation-dissipation relation is derived which relates the strength of a stochastic backscatter term in the energy decay equation to the mean of the energy dissipation rate. The theory is based on the so-called “effective action” of the energy history and illustrates a Rayleigh-Ritz method recently developed to evaluate the effective action approximately within probability density-function (PDF) closures. These effective actions generalize the Onsager-Machlup action of nonequilibrium statistical mechanics to turbulent flow and yield detailed, concrete predictions for fluctuations, such as multi-time correlation functions of arbitrary order. They also characterize the mean histories by a variational principle.
Everolimus-induced activation of latent Mycobacterium tuberculosis infection in a patient with metastatic renal cell carcinoma

Copyright © 2017 The Korean Association of Internal Medicine This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/ by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Korean J Intern Med 2017;32:365-368 https://doi.org/10.3904/kjim.2015. 121
Comparison of Social Responsibility Information Disclosure Media Used by Canadian Firms

This study examines the social responsibility information disclosed through mass media vehicles by Canadian companies operating in the banking and petroleum industries. The analysis compares disclosures, made through mass media vehicles such as magazine, radio and television advertisements and company brochures, with those made through the company′s annual reports. Results indicated that the mass media vehicles were used extensively, but that they provided less information in the quantitative and monetary form than did the annual reports. In addition, information provided through the mass media vehicles dealt with only a few information categories. Comparison across the firms by industry indicated that there was a large interfirm difference in the usage of these media for making social disclosure. It is, therefore, felt that annual reports alone perhaps do not adequately represent the information disclosure activities of a firm or an industry.