Miracle-dz/UniFAR-FTUs huggingface dataset:
Procarbazine, CCNU, and Vincristine Chemotherapy in Gliomatosis Cerebri

A 49-year-old female patient was admitted due to memory disturbances. Magnetic resonance (MR) imaging suggested gliomatosis cerebri (GC), which had spread to both insular lobes, both frontal and basal ganglia and the brain stem. A stereotactic biopsy was performed at the high signal intensity area of the T2-weighted MR image, and the revealed a diffuse astrocytoma. Radiation therapy was judged not to be an appropriate treatment for the patient because of her cognitive impairment. A combinatorial chemotherapy regiment consisting of Procarbazine, CCNU, and Vincristine (PCV) was agreed upon after discussion. The patient underwent six cycles of PCV chemotherapy (a full dose was applied until the 3rd cycle, and dose then was reduced to 75% for the remaining cycles). Although the patient exhibited side effects such as bone marrow suppression and gastrointestinal symptoms, these were managed by medication. Over the 28 months following initiation of treatment, the high signal area in the right frontal and temporal lobes in the T2-weighted MR image decreased, and the patient's cognitive function [global deterioration scale (GDS) 4 points, mini-mental state examination (MMSE) 25 point] also improved (GDS 1 points, MMSE 29 points). PCV chemotherapy can therefore be an alternative therapeutic option for patients with GC who cannot be treated with radiation therapy or other chemotherapies.
Genetic signature of adult gliomas and correlation with MRI features

In recent years the amount of information concerning the genetics and the biology of gliomas, and particularly of glioblastoma multiforme, increased steadily. Such an increase has been paralleled by the technological progress of MRI. The merging of these scientific areas, as summarized in this review, is helping the stratification of glioma patients for clinical trials and their clinical follow-up. Although available therapeutic options appear limited in number, it is likely that in the next 5 years, both as a consequence of the increased knowledge due to genomic sequencing of hundreds of glioblastoma specimens and to continuous improvements of MRI, new perspectives will be available for these patients, with a sizable impact on their prognosis.
Transition from Localized Corrosion to Stress Corrosion Cracking in an Al-Li-Cu-Ag Alloy

Abstract The early stages of stress-assisted corrosion and stress corrosion crack (SCC) initiation from machine-notched aluminum alloy (AA) 2096 (UNS A92096) specimens, lacking prefatigue cracks, were investigated. Double-notched tensile specimens of an extremely SCC-susceptible underaged (i.e., 4-h artificially aging at 160°C) temper of AA2096 were exposed in an alternate immersion (A/I) 0.6 sodium chloride (NaCl) environment. Focused ion beam (FIB) sectioning/secondary electron imaging methods were used to study and document the earliest stages of pit, intersubgranular corrosion, corrosion fissure, and SCC development starting from LT surfaces. SCC in machine-notched AA2096 involved several stages: trenching of the alloy matrix along bands of constituent particles, constituent particle-induced pit or trench coalescence, elongated corrosion fissure growth initially by general dissolution on the length scale of subgrains and the transition to intersubgranular attack, followed by the initiation/transition .
Phyto-SERM Constitutes from Flemingia macrophylla

The methanolic extract of Flemingia macrophylla roots exhibited significant estrogenic activity in the transgenic plant assay system which was comparable to the activity of soybean extract. Utilizing estrogenic activity-guided fractionation, one new compound, fleminigin, together with 23 known compounds were isolated from F. macrophylla roots’ methanolic extract. The structure of the new compound was identified based on intensive spectroscopic analysis and the full spectral data for one of the isolated compounds, flemichin E, was introduced for the first time in the current investigation. The estrogenic and anti-estrogenic activities of the isolated compounds were evaluated revealing that the isolated isoflavonoids may act as partial estrogen agonists, as well as antagonists. Additionally, the anti-inflammatory and the cytotoxic activities of the isolated compounds were studied. These results suggested the potential applications of F. macrophylla extract and its isolated compounds as selective estrogen receptor modulators (SERMs).
The First International Chinese Word Segmentation Bakeoff

This paper presents the results from the ACL-SIGHAN-sponsored First International Chinese Word Segmentation Bakeoff held in 2003 and reported in conjunction with the Second SIGHAN Workshop on Chinese Language Processing, Sapporo, Japan. We give the motivation for having an international segmentation contest (given that there have been two within-China contests to date) and we report on the results of this first international contest, analyze these results, and make some recommendations for the future.
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: Linear right-of-ways are ubiquitous in the United States and may alter vertebrate populations, yet they remain little studied. We examined the relationship between these areas and common raven ( Corvus corax ) and red-tailed hawk ( Buteo jamaicensis ) populations in the Mojave Desert of California by flying helicopter transects along paved highways, transmission powerlines, and control areas (i.e., no highways nor powerlines within 3.2 km). Ravens were equally (P > 0.10) common along highway and powerline transects, but were more (P < 0.02) abundant along these transects than along controls. Raven nests were more (P < 0.0001) abundant along powerlines than along either highways or controls. Red-tailed hawks and their nests were more (P < 0.0001) abundant along powerlines than along either highway or control transects. Neither species used potential nest or perch sites in proportion to their availability. Ravens used power poles as nest sites more (P < 0.001) than expected based on availability, but not (P > 0.10) as perch sites. Red-tailed hawks used power poles for both nesting and perching more (P < 0.001) than expected based on availability. Our data suggest that ravens are more abundant along highways because of automobile-generated carrion, whereas both ravens and red-tailed hawks are more common along powerlines because of the presence of superior perch and nest sites. We recommend that land managers evaluate possible changes in vertebrate populations and community-level interactions when assessing the effects of future linear right-of-way projects.
A Dynamic Logic of Normative Systems

We propose a logical framework to represent and reason about agent interactions in normative systems. Our starting point is a dynamic logic of propositional assignments whose satisfiability problem is PSPACE-complete. We show that it embeds Coalition Logic of Propositional Control CL-PC and that various notions of ability and capability can be captured in it. We illustrate it on a water resource management case study. Finally, we show how the logic can be easily extended in order to represent constitutive rules which are also an essential component of the modelling of social reality.
Consistent updates for software-defined networks: change you can believe in!

Configuration changes are a common source of instability in networks, leading to broken connectivity, forwarding loops, and access control violations. Even when the initial and final states of the network are correct, the update process often steps through intermediate states with incorrect behaviors. These problems have been recognized in the context of specific protocols, leading to a number of point solutions. However, a piecemeal attack on this fundamental problem, while pragmatic in the short term, is unlikely to lead to significant long-term progress. Software-Defined Networking (SDN) provides an exciting opportunity to do better. Because SDN is a clean-slate platform, we can build general, reusable abstractions for network updates that come with strong semantic guarantees. We believe SDN desperately needs such abstractions to make programs simpler to design, more reliable, and easier to validate using automated tools. Moreover, we believe these abstractions should be provided by a runtime system, shielding the programmer from these concerns. We propose two simple, canonical, and effective update abstractions, and present implementation mechanisms. We also show how to integrate them with a network programming language, and discuss potential applications to program verification.
Ect2 and MgcRacGAP regulate the activation and function of Cdc42 in mitosis

Although Rho regulates cytokinesis, little was known about the functions in mitosis of Cdc42 and Rac. We recently suggested that Cdc42 works in metaphase by regulating bi-orient attachment of spindle microtubules to kinetochores. We now confirm the role of Cdc42 by RNA interference and identify the mechanisms for activation and down-regulation of Cdc42. Using a pull-down assay, we found that the level of GTP-Cdc42 elevates in metaphase, whereas the level of GTP-Rac does not change significantly in mitosis. Overexpression of dominant-negative mutants of Ect2 and MgcRacGAP, a Rho GTPase guanine nucleotide exchange factor and GTPase activating protein, respectively, or depletion of Ect2 by RNA interference suppresses this change of GTP-Cdc42 in mitosis. Depletion of Ect2 also impairs microtubule attachment to kinetochores and causes prometaphase delay and abnormal chromosomal segregation, as does depletion of Cdc42 or expression of the Ect2 and MgcRacGAP mutants. These results suggest that Ect2 and MgcRacGAP regulate the activation and function of Cdc42 in mitosis.
Vicarious Trauma Among Sexual Assault Nurse Examiners

ABSTRACT Vicarious trauma (VT), the phenomenon of changes in cognition and worldview that result from empathic response and repeated exposure to narratives of trauma, is a risk for helping professionals. This descriptive, correlational study sought to examine levels of VT among sexual assault nurse examiners (SANEs) as compared with other women’s health nurses. It also explored whether levels of VT are different for nurses who have experienced primary trauma alone, VT alone, or both personal trauma and VT. VT was assessed through an anonymous online survey using the nurses’ total scores on the Trauma and Attachment Belief Scale. Trauma and Attachment Belief Scale scores were significantly higher for SANEs (M = 178.5, SD = 42.6) than for women’s health nurses (M = 168.1, SD = 41.4; p = 0.025), indicating higher levels of trauma-related cognitive disruption in the SANE group. Scores were also significantly higher for both groups with personal trauma histories at the p < 0.05 level compared with the women’s health nurses with no personal history. SANEs who had no personal history of trauma did not differ significantly from either group of nurses who did, suggesting that VT from working as an SANE is associated with levels of cognitive disruption similar to oneself having experienced trauma. Nurses should be aware of this phenomenon and its sequelae when choosing to pursue the specialty of sexual assault nursing. Hospitals and other organizations employing SANEs should also be aware of VT and provide a support system with resources in place to mitigate these effects. Future research should further explore effects of primary trauma versus VT, clinical manifestations and significance of varying levels of VT, and interventions and strategies for dealing with VT.
CTCF and its protein partners: divide and rule?

CTCF is a ubiquitous transcription factor that is involved in numerous, seemingly unrelated functions. These functions include, but are not limited to, positive or negative regulation of transcription, enhancer-blocking activities at developmentally regulated gene clusters and at imprinted loci, and X-chromosome inactivation. Here, we review recent data acquired with state-of-the-art technologies that illuminate possible mechanisms behind the diversity of CTCF functions. CTCF interacts with numerous protein partners, including cohesin, nucleophosmin, PARP1, Yy1 and RNA polymerase II. We propose that CTCF interacts with one or two different partners according to the biological context, applying the Roman principle of governance, `divide and rule' (divide et impera).
Evaluating & improving fault localization techniques

A fault localization technique takes as input a faulty program, and it produces as output a ranked list of suspicious code locations at which the program may be defective. When researchers propose a new fault localization technique, they evaluate it on programs with known faults; they score the technique based on where in its output list the defective code appears. This enables comparison of multiple fault localization techniques to determine which one is better. Previous research has evaluated fault localization techniques using artificial faults, generated either by mutation tools or manually. In other words, previous research has determined which fault localization techniques are best at finding artificial faults. However, it is not known which fault localization techniques are best at finding real faults. It is not obvious that the answer is the same, given previous work showing that artificial faults have both similarities to and differences from real faults. We performed a replication study to evaluate 10 claims in the literature that compared fault localization techniques. We used 2273 artificial faults in 5 real-world programs. Our results refute 3 of the previous claims. Then, we evaluated the same 10 claims, using 297 real faults from the 5 programs. Every previous result was refuted or was statistically insignificant. In other words, our experiments show that artificial faults are not useful for predicting which fault localization techniques perform best on real faults. In light of these results, we identified a design space that includes many previously-studied fault localization techniques as well as hundreds of new techniques. We experimentally determined which factors in the design space are most important. Then, we extended it with new techniques. Several of our novel techniques outperform all existing techniques, notably in terms of ranking defective code in the top-5 or top-10 reports.
Solving Cooperative Reliability Games

Cooperative games model the allocation of profit from joint actions, following considerations such as stability and fairness. We propose the reliability extension of such games, where agents may fail to participate in the game. In the reliability extension, each agent only "survives" with a certain probability, and a coalition's value is the probability that its surviving members would be a winning coalition in the base game. We study prominent solution concepts in such games, showing how to approximate the Shapley value and how to compute the core in games with few agent types. We also show that applying the reliability extension may stabilize the game, making the core non-empty even when the base game has an empty core.
Mechanical tests for validation of seismic isolation elastomer constitutive models

High damping laminated elastomeric bearings are becoming the preferred device for seismic isolation of large buildings and structures, such as nuclear power plants. The key component of these bearings is a filled natural rubber elastomer. This material exhibits nonlinear behavior within the normal design range. The material damping cannot be classified as either viscous or hysteritic, but it seems to fall somewhere in between. This paper describes a series of tests that can be used to characterize the mechanical response of these elastomers. The tests are designed to determine the behavior of the elastomer in the time scale of the earthquake, which is typically from 30 to 60 seconds. The test results provide data for use in determining the material parameters associated with nonlinear constitutive models. 4 refs.
The Significance of Interferon-γ in HIV-1 Pathogenesis, Therapy, and Prophylaxis

Interferon-γ (IFNγ) plays various roles in the pathogenesis of HIV/AIDS. In an HIV-1 infected individual, the production of IFNγ is detected as early as the acute phase and continually detected throughout the course of infection. Initially produced to clear the primary infection, IFNγ together with other inflammatory cytokines are involved in establishing a chronic immune activation that exacerbates clinical diseases associated with AIDS. Unlike Type 1 IFNs, IFNγ has no direct antiviral activity against HIV-1 in primary cultures, as supported by the in vivo findings of IFNγ therapy in infected subjects. Results from both in vitro and ex vivo studies show that IFNγ can instead enhance HIV-1 replication and its associated diseases, and therapies aimed at decreasing its production are under consideration. On the other hand, IFNγ has been shown to enhance cytotoxic T lymphocytes and NK cell activities against HIV-1 infected cells. These activities are important in controlling HIV-1 replication in an individual and will most likely play a role in the prophylaxis of an effective vaccine against HIV-1. Additionally, IFNγ has been used in combination with HIV-1 vaccine to augment antiviral immunity. Technological advancements have focused on using IFNγ as a biological marker to analyze the type(s) of immunity generated by candidate HIV vaccines and the levels of immunity restored by anti-retroviral drug therapies or novel immunotherapies. Hence, in addition to its valuable ancillary role as a biological marker for the development of effective HIV-1 prophylactic and therapeutic strategies, IFNγ has a vital role in promoting the pathogenesis of HIV.
Transient Expression of PG‐M/Versican, a Large Chondroitin Sulfate Proteoglycan in Developing Chicken Retina

Abstract: We previously showed the expression of PG‐M/versican in embryonic chicken retina. In this study, we characterized the alternatively spliced forms of PG‐M/versican and their developmental regulation to investigate the implication of PG‐M/versican in neurite outgrowth from retinal cells during development. On day 5, the immunolocalization of PG‐M was first observed at the inner surface of neural retina. On day 7, the pronounced staining was observed in the nerve fiber layer and inner plexiform layer where neural networks of ganglion cells were being formed. As the development proceeded, more intensive staining was observed in these layers. The staining peaked on day 14 and then decreased. Northern analysis and western blotting revealed the presence of a single‐sized transcript (13 kb) and the PG‐M/versican core protein (550 kDa) on day 14, but the absence of any transcripts or protein bands on day 20, indicating a transient expression of PG‐M+ (VO), the alternatively spliced form with the most abundant sites for the chondroitin sulfate attachment. Taken together, it is likely that PG‐M/versican is involved in neurite outgrowth from ganglion cells during retinal development, and antiadhesion activity of its chondroitin sulfate chains may be important for regulation.
Oral versus intravenous antibiotic treatment for febrile neutropenia in cancer patients.

BACKGROUND Fever occurring in a neutropenic patient remains a common life-threatening complication of cancer chemotherapy. The common practice is to admit the patient to hospital and treat him or her empirically with intravenous broad-spectrum antibiotics. Oral therapy could be an alternative approach for selected patients. OBJECTIVES To compare the efficacy of oral antibiotics versus intravenous (IV) antibiotic therapy in febrile neutropenic cancer patients. SEARCH METHODS The Cochrane Central Register of Controlled Trials (CENTRAL) (2013, Issue 1) in The Cochrane Library, MEDLINE (1966 to January week 4, 2013), EMBASE (1980 to 2013 week 4) and LILACS (1982 to 2007). We searched several databases for ongoing trials. We checked the conference proceedings of the Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC) (1995 to 2007), and all references of included studies and major reviews were scanned. SELECTION CRITERIA Randomised controlled trials (RCTs) comparing oral antibiotic(s) to intravenous antibiotic(s) for the treatment of neutropenic cancer patients with fever. The comparison between the two could be started initially (initial oral) or following an initial course of intravenous antibiotic treatment (sequential). DATA COLLECTION AND ANALYSIS Two review authors independently assessed trial eligibility and methodological quality and extracted data. Data concerning mortality, treatment failures and adverse events were extracted from the included studies assuming an 'intention-to-treat' basis for the outcome measures whenever possible. Risk ratios (RR) with 95% confidence intervals (CI) were estimated for dichotomous data. Risk of bias assessment was also made in line with methodology of The Cochrane Collaboration. MAIN RESULTS Twenty-two trials (3142 episodes in 2372 patients) were included in the analyses. The mortality rate was similar when comparing oral to intravenous antibiotic treatment (RR 0.95, 95% CI 0.54 to 1.68, 9 trials, 1392 patients, median mortality 0, range 0% to 8.8%). Treatment failure rates were also similar (RR 0.96, 95% CI 0.86 to 1.06, all trials). No significant heterogeneity was shown for all comparisons but adverse events. The effect was stable in a wide range of patients. Quinolones alone or combined with another antibiotic were used with comparable results. Adverse reactions, mostly gastrointestinal, were more common with oral antibiotics. AUTHORS' CONCLUSIONS Based on the present data, oral treatment is an acceptable alternative to intravenous antibiotic treatment in febrile neutropenic cancer patients (excluding patients with acute leukaemia) who are haemodynamically stable, without organ failure, and do not have pneumonia, infection of a central line or a severe soft-tissue infection. The wide CI for mortality allows the present use of oral treatment in groups of patients with an expected low risk for mortality, and further research should be aimed at clarifying the definition of low risk patients.
Inferring deterministic causal relations

We consider two variables that are related to each other by an invertible function. While it has previously been shown that the dependence structure of the noise can provide hints to determine which of the two variables is the cause, we presently show that even in the deterministic (noise-free) case, there are asymmetries that can be exploited for causal inference. Our method is based on the idea that if the function and the probability density of the cause are chosen independently, then the distribution of the effect will, in a certain sense, depend on the function. We provide a theoretical analysis of this method, showing that it also works in the low noise regime, and link it to information geometry. We report strong empirical results on various real-world data sets from different domains.