Miracle-dz/UniFAR-FTUs huggingface dataset:
Into the Intracellular Logistics of Cross-Presentation

The induction of cytotoxic CD8+ T cell responses requires the presentation of antigenic peptides by MHC class I molecules (MHC I). MHC I usually present peptides derived from endogenous proteins. However, some subtypes of dendritic cells have developed the ability to efficiently present peptides derived from exogenous antigens on MHC I via a process called cross-presentation. Cross-presentation is intimately linked to the induction of anti-viral, -bacterial, and -tumor cytotoxic T cell (CTL) responses, as well as a wide variety of CTL-mediated diseases and transplant rejections. The molecular and cellular mechanisms underlying cross-presentation have been studied intensively since its original description, yet understanding of this process is incomplete and on the forefront of immunological research. Numerous pathways and models, some of them conflicting, have been described so far. Here, we review the various pathways reported as involved in cross-presentation, highlighting the complexity of this process. We also discuss in detail the different intracellular steps required, from antigen capture and routing, to processing, and finally peptide loading, emphasizing the need for a better understanding of the cell biology of this phenomenon.
PREANNOUNCED OPTIMAL TAX REFORM

In constitutional democracies, laws take time to be deliberated upon, to be passed, and to be implemented. Motivated by this observation, we study the properties of optimal tax reform when it has to be announced in advance of its implementation. We find that a delay between announcement and implementation has large effects on the optimal fiscal policy during the transition to the new steady state. On the other hand, we find that the welfare gains from optimal tax reform are fairly robust to the introduction of an implementation lag. Increasing the lag from zero to four years reduces the welfare gains by less than a quarter. Moreover, it turns out that this reduction of the welfare gain is mainly due to the delay itself rather than the effect of preannouncement on the character of the optimal tax reform.
Intrinsic Coupling between Gamma Oscillations, Neuronal Discharges, and Slow Cortical Oscillations during Human Slow-Wave Sleep

In the first electrocorticograms, Richard [Caton (1877)][1] connected a mirror galvanometer to exposed rabbit brains and observed slow sleep-related fluctuations. Several decades later, [Loomis et al. (1937)][2] applied the then-fledgling technique of scalp EEG to classify sleep stages in humans,
Nonlinear damping in mechanical resonators based on graphene and carbon nanotubes

The theory of damping finds its roots in Newton’s Principia [1] and has been exhaustively tested in objects as disparate as the Foucault pendulum, mirrors used in gravitational-wave detectors, and submicron mechanical resonators. Owing to recent advances in nanotechnology it is now possible to explore damping in systems with transverse dimensions on the atomic scale. Here, we study the damping of mechanical resonators based on a carbon nanotube [2-11] as well as on a graphene sheet [12-15], the ultimate one and two-dimensional nanoelectromechanical systems (NEMS). The damping is found to strongly depend on the amplitude of the motion; it is well described by a nonlinear force
Repeated Nipple Fluid Aspiration: Compliance and Feasibility Results from a Prospective Multicenter Study

Background Despite intensive surveillance, a high rate of interval malignancies is still seen in women at increased breast cancer risk. Therefore, novel screening modalities aiming at early detection remain needed. The intraductal approach offers the possibility to directly sample fluid containing cells, DNA and proteins from the mammary ductal system where, in the majority of cases, breast cancer originates. Fluid from the breast can non-invasively be obtained by oxytocin-assisted vacuum aspiration, called nipple fluid aspiration (NFA). The goal of this feasibility study was to evaluate the potential of repeated NFA, which is a critical and essential step to evaluate its possible value as a breast cancer screening method. Methods In this multicenter, prospective study, we annually collected nipple fluid for up to 5 consecutive years from women at increased breast cancer risk, and performed a questionnaire-based survey regarding discomfort of the aspiration. Endpoints of the current interim analyses were the feasibility and results of 994 NFA procedures in 451 women with total follow-up of 560 person years of observation. Results In this large group of women at increased risk of breast cancer, repetitive NFA appeared to be feasible and safe. In 66.4% of aspirated breasts, nipple fluid was successfully obtained. Independent predictive factors for successful NFA were premenopausal status, spontaneous nipple discharge, smaller breast size, bilateral oophorectomy and previous use of hormone replacement therapy or anti-hormonal treatment. The procedure was well tolerated with low discomfort. Drop-out rate was 20%, which was mainly due to repeated unsuccessful aspiration attempts. Only 1.6% of women prematurely declined further participation because of side effects. Conclusions Repeated NFA in women at increased breast cancer risk is feasible and safe. Therefore, NFA is a promising method to non-invasively obtain a valuable source of potential breast cancer specific biomarkers.
Uncovering the Social Deficits in the Autistic Brain. A Source-Based Morphometric Study

Autism is a neurodevelopmental disorder that mainly affects social interaction and communication. Evidence from behavioral and functional MRI studies supports the hypothesis that dysfunctional mechanisms involving social brain structures play a major role in autistic symptomatology. However, the investigation of anatomical abnormalities in the brain of people with autism has led to inconsistent results. We investigated whether specific brain regions, known to display functional abnormalities in autism, may exhibit mutual and peculiar patterns of covariance in their gray-matter concentrations. We analyzed structural MRI images of 32 young men affected by autistic disorder (AD) and 50 healthy controls. Controls were matched for sex, age, handedness. IQ scores were also monitored to avoid confounding. A multivariate Source-Based Morphometry (SBM) was applied for the first time on AD and controls to detect maximally independent networks of gray matter. Group comparison revealed a gray-matter source that showed differences in AD compared to controls. This network includes broad temporal regions involved in social cognition and high-level visual processing, but also motor and executive areas of the frontal lobe. Notably, we found that gray matter differences, as reflected by SBM, significantly correlated with social and behavioral deficits displayed by AD individuals and encoded via the Autism Diagnostic Observation Schedule scores. These findings provide support for current hypotheses about the neural basis of atypical social and mental states information processing in autism.
Taylor's rule and the Fed, 1970-1997

This paper estimates a simple model of the Federal Reserve's "reaction function" - that is, the relationship between economic developments and the fed's response to them. We focus on how this estimated reaction function has changed over time. Such changes are not surprising given compositional changes in the Federal Open Market Committee, and we consider three subsamples delineated by the terms of recent fed Chairmen. We find that the estimated reaction functions for each period vary in ways that seem broadly consistent with the success or failure during the period at controlling inflation. These results suggest that a Taylor-rule framework is a useful way to summarize key elements of monetary policy.
Time course of electromagnetic activity associated with detection of rare events

The neural origins of the cortical response to rare sensory events remain poorly understood. Using simultaneous event-related potentials and magnetic resonance imaging, we investigated the anatomical profile of regional activity at various processing stages during performance of auditory and visual variants of an oddball paradigm. The earliest rarity-detection response was found in sensory-specific cortices, rapidly spreading to tertiary association areas, mesial temporal and frontal cortices by 150–200 ms. P3m-related activity was not found in sensory-specific cortices. On the basis of the anatomic distribution of P3m-related activity, this component is likely to reflect more generalized cognitive abilities hosted by association cortical regions.
Dirac Action on M5 and M2 Branes with Bulk Fluxes

We derive an explicit form of the quadratic in fermions Dirac action on the M5 brane for an arbitrary on-shell background of 11D supergravity with non-vanishing fluxes and in presence of a chiral 2-form on M5. This action may be used to generalize the conditions for which the non-perturbative superpotential can be generated in M/string theory. We also derive the Dirac action with bulk fluxes on the M2 brane.
Diet diversity and nutritional status among adults in southwest China

Background With rapid urbanization in the past decades, diet diversity continues to increase in China. The present cross-sectional study aims to explore the association between dietary diversity and nutritional status among adults in southwest China. Methods This study used data from 2011–2012 National Nutritional Survey in Yunnan Province, southwest China (N = 1105). Data of three consecutive 24-hour dietary recalls were used to calculate dietary diversity scores (DDS) and nutrient adequacy ratio (NAR). Body mass index and waist circumference were used to determine nutritional status. Surveylogistic procedure of SAS 9.2 software was used to examine the association between DDS and obesity by estimating odds ratio (OR) and 95% confidence intervals (CI). Results The mean DDS was 5.2 (SD 1.1) out of nine points. Being female, younger age, belonging to Han ethnicity, having higher educational level and household income were positively associated with DDS (all P<0.05). As DDS increased, consumption also increased in most food groups except grains and vegetables. People with medium and high DDS (DDS = 5 and DDS ≥6, respectively) ingested more energy than the recommended quantity(NAR = 1.1 and 1.2, respectively). However, the intakes of Calcium and Vitamin A were seriously inadequate even for people with high DDS (NAR≤0.5). With potential confounders adjusted, people with medium and high DDS were at higher risk of general and central obesity than people with DDS ≤4 (OR = 1.4–1.9, P<0.01). Conclusions Our data indicated that high DDS was associated with excessive energy intake and obesity among adults in southwest China. Although dietary diversity is widely recommended, public health messages should give less emphasis on dietary diversity.
Intrusion-Related Gold Mineral Occurrences of the Bayonne Magmatic Belt

Intrusion-related gold deposits, as described by Thompson et al. (1999), are a new and economically important class of deposits that occur within felsic magmatic provinces known to host tungsten and/or tin mineralization. Traditionally these magmatic provinces were not believed to host significant gold mineralization and as a consequence are under explored for this type of deposit. Examples of intrusion-related gold deposits occur worldwide (Thompson et al., 1999, Lang and Baker, 2001), but those most applicable to exploration in British Columbia are the well-studied Alaska and Yukon deposits of the Tintina Gold Belt (Newberry et al., 1995; McCoy et al., 1997; Baker et al., 1996). Major deposits include Fort Knox (~210 t Au), Dublin Gulch (~36 t Au), Brewery Creek (~29 t Au) and Pogo (~161 t Au).
Fine cross slip of a screw dislocation in anti-plane shear

In this work we present the main results of Armano and Cermelli [1 ] regarding the motion of a screw dislocation in a crystalline solid. It is well known that dislocations can only move along a finite number of crystallographic directi ons: in two dimensions, the resulting trajectories are piecewise rectilinear paths. H owever, in special situations such as near an attractor, dislocations are forced to move along curv ed paths: we characterize this class of motions as fine mixtures of crystallographic motions, u sing the notion of generalized curves due to L. C. Young, and explicitly compute the parametri z d measure associated to a sequence of polygonals.
Endomicroscopy and Cancer: A New Approach to the Visualization of Neoangiogenesis

Probe-based Confocal Laser Endomicroscopy (pCLE) is a novel imaging technique for gastrointestinal endoscopy providing in vivo microscopy at subcellular resolution. It offers the possibility to analyze neoangiogenesis and vessel density in vivo. Angiogenetic switch is essential in cancer progression. Aim of the paper was to review the use of this imaging tool to analyze colorectal and gastric cancers vascularization in vivo. The aim is to provide the possibility of combining diagnostic evidences with vascularization and molecular profile to evaluate the efficacy of an antiangiogenic treatment in association with conventional therapy. pCLE can be considered a revolutionary method for real-time assessment of changes in vascularization pattern in this tumors and it may open the possibility to address the use of anti-angiogenic therapy in order to improve the outcome of the treatment.
Is Complexity Leadership Theory Complex Enough? A critical appraisal, some modifications and suggestions for further research

Scholars are increasingly seeking to develop theories that explain the underlying processes whereby leadership is enacted. This shifts attention away from the actions of ‘heroic’ individuals and towards the social contexts in which people with greater or lesser power influence each other. A number of researchers have embraced complexity theory, with its emphasis on non-linearity and unpredictability. However, some complexity scholars still depict the theory and practice of leadership in relatively non-complex terms. They continue to assume that leaders can exercise rational, extensive and purposeful influence on other actors to a greater extent than is possible. In effect, they offer a theory of complex organizations led by non-complex leaders who establish themselves by relatively non-complex means. This testifies to the enduring power of ‘heroic’ images of leader agency. Without greater care, the terminology offered by complexity leadership theory could become little more than a new mask for old theories that legitimize imbalanced power relationships in the workplace. This paper explores how these problems are evident in complexity leadership theory, suggests that communication and process perspectives help to overcome them, and outlines an agenda for further research on these issues.
The Social Interaction Of Students With Disabilities In Learning In Higher Education

Social interaction is a relationship between two people or more that happens because of connected communication and socialization. In this study, social interaction is defined as the interactions between students with disabilities and regular students in a class, the social interaction among students with disabilities, and the social interaction between students with disabilities and volunteers. The social interactions by the students with disabilities in class appear in various patterns because of the different conditions of each student, communication methods, language perceptions, peers acceptance in class, volunteers and the students with disabilities themselves. This research is conducted to know the pattern of students with disabilities social interaction in learning session in the classroom. The research method used is a qualitative research with a case study approach. The data were collected through observation, interview, and documentation. The research subjects were students with disabilities, regular students, and volunteers. The result revealed that there are two patterns of social interaction in a class learning session. The first is the positive social interaction, formed by cooperations, understanding in communication, and acceptances from two sides. The other is the negative social interaction, the one with difficulties because some factors such as communication barrier, introvert personalities of students with disabilities, and the fears to start a communication. Keywords—social interaction; students with disabilities; higher education; learning session.
Population-Based Passive Tick Surveillance and Detection of Expanding Foci of Blacklegged Ticks Ixodes scapularis and the Lyme Disease Agent Borrelia burgdorferi in Ontario, Canada

We identified ticks submitted by the public from 2008 through 2012 in Ontario, Canada, and tested blacklegged ticks Ixodes scapularis for Borrelia burgdorferi and Anaplasma phagocytophilum. Among the 18 species of ticks identified, I. scapularis, Dermacentor variabilis, Ixodes cookei and Amblyomma americanum represented 98.1% of the 14,369 ticks submitted. Rates of blacklegged tick submission per 100,000 population were highest in Ontario's Eastern region; D. variabilis in Central West and Eastern regions; I. cookei in Eastern and South West regions; and A. americanum had a scattered distribution. Rates of blacklegged tick submission per 100,000 population were highest from children (0–9 years old) and older adults (55–74 years old). In two health units in the Eastern region (i.e., Leeds, Grenville & Lanark District and Kingston-Frontenac and Lennox & Addington), the rate of submission for engorged and B. burgdorferi-positive blacklegged ticks was 47× higher than the rest of Ontario. Rate of spread for blacklegged ticks was relatively faster and across a larger geographic area along the northern shore of Lake Ontario/St. Lawrence River, compared with slower spread from isolated populations along the northern shore of Lake Erie. The infection prevalence of B. burgdorferi in blacklegged ticks increased in Ontario over the study period from 8.4% in 2008 to 19.1% in 2012. The prevalence of B. burgdorferi-positive blacklegged ticks increased yearly during the surveillance period and, while increases were not uniform across all regions, increases were greatest in the Central West region, followed by Eastern and South West regions. The overall infection prevalence of A. phagocytophilum in blacklegged ticks was 0.3%. This study provides essential information on ticks of medical importance in Ontario, and identifies demographic and geographic areas for focused public education on the prevention of tick bites and tick-borne diseases.
Order-Dependent Modulation of Directional Signals in the Supplementary and Presupplementary Motor Areas

To maximize reward and minimize effort, animals must often execute multiple movements in a timely and orderly manner. Such movement sequences must be usually discovered through experience, and during this process, signals related to the animal's action, its ordinal position in the sequence, and subsequent reward need to be properly integrated. To investigate the role of the primate medial frontal cortex in planning and controlling multiple movements, monkeys were trained to produce a series of hand movements instructed by visual stimuli. We manipulated the number of movements in a sequence across trials, making it possible to dissociate the effects of the ordinal position of a given movement and the number of remaining movements necessary to obtain reward. Neurons in the supplementary and presupplementary motor areas modulated their activity according to the number of remaining movements, more often than in relation to the ordinal position, suggesting that they might encode signals related to the timing of reward or its temporally discounted value. In both cortical areas, signals related to the number of remaining movements and those related to movement direction were often combined multiplicatively, suggesting that the gain of the signals related to movements might be modulated by motivational factors. Finally, compared with the supplementary motor area, neurons in the presupplementary motor area were more likely to increase their activity when the number of remaining movements is large. These results suggest that these two areas might play complementary roles in controlling movement sequences.
Working together: Collaborative strategies for developing effective professional relationships in the practicum

INTRODUCTION This paper derives from research which examined the development of the professional relationship between associate teachers and student teachers during the final block practicum. Through my professional experiences as an associate teacher in primary schools and more recently as a school liaison lecturer in the School of Education, University of Waikato, I developed an interest in the way professional relationships developed between associate teachers and student teachers. The main purpose of the study was to firstly identify principles which appeared to be important to the development of the professional relationship, and secondly to identify specific strategies associate teachers employed to support and enhance the professional development of their student teachers. As the study developed four main themes emerged. The first theme, personal connectedness, highlighted how important it was to make connections on both a personal and professional level. The second theme, collaboration, emphasised the
HCV treatment rates and sustained viral response among people who inject drugs in seven UK sites: real world results and modelling of treatment impact

Hepatitis C virus (HCV) antiviral treatment for people who inject drugs (PWID) could prevent onwards transmission and reduce chronic prevalence. We assessed current PWID treatment rates in seven UK settings and projected the potential impact of current and scaled‐up treatment on HCV chronic prevalence. Data on number of PWID treated and sustained viral response rates (SVR) were collected from seven UK settings: Bristol (37–48% HCV chronic prevalence among PWID), East London (37–48%), Manchester (48–56%), Nottingham (37–44%), Plymouth (30–37%), Dundee (20–27%) and North Wales (27–33%). A model of HCV transmission among PWID projected the 10‐year impact of (i) current treatment rates and SVR (ii) scale‐up with interferon‐free direct acting antivirals (IFN‐free DAAs) with 90% SVR. Treatment rates varied from <5 to over 25 per 1000 PWID. Pooled intention‐to‐treat SVR for PWID were 45% genotypes 1/4 [95%CI 33–57%] and 61% genotypes 2/3 [95%CI 47–76%]. Projections of chronic HCV prevalence among PWID after 10 years of current levels of treatment overlapped substantially with current HCV prevalence estimates. Scaling‐up treatment to 26/1000 PWID annually (achieved already in two sites) with IFN‐free DAAs could achieve an observable absolute reduction in HCV chronic prevalence of at least 15% among PWID in all sites and greater than a halving in chronic HCV in Plymouth, Dundee and North Wales within a decade. Current treatment rates among PWID are unlikely to achieve observable reductions in HCV chronic prevalence over the next 10 years. Achievable scale‐up, however, could lead to substantial reductions in HCV chronic prevalence.