Miracle-dz/UniFAR-FTUs huggingface dataset:
Rapid Identification of Burkholderia pseudomallei by Latex Agglutination Based on an Exopolysaccharide-Specific Monoclonal Antibody

ABSTRACT We recently identified a constitutively expressed exopolysaccharide of Burkholderia pseudomallei which is composed of a unique linear tetrasaccharide repeating unit consisting of three galactose residues and one 3-deoxy-d-manno-2-octulosonic acid residue. In this study we developed a latex agglutination test based on monoclonal antibody 3015, which is specific for this exopolysaccharide, and evaluated this test for rapid identification ofB. pseudomallei grown on agar plates. All 74 environmental and clinical B. pseudomallei strains tested, originating from different areas of Southeast Asia, northern Australia, and Africa, showed a strong and specific agglutination. B. pseudomallei-like organisms and a variety of other bacteria did not react. In conclusion this monoclonal antibody-based test is a simple, rapid, and highly specific method for identifying B. pseudomallei culture isolates from different geographic areas.
Harnessing Sequence Labeling for Sarcasm Detection in Dialogue from TV Series ‘Friends’

This paper is a novel study that views sarcasm detection in dialogue as a sequence labeling task, where a dialogue is made up of a sequence of utterances. We create a manuallylabeled dataset of dialogue from TV series ‘Friends’ annotated with sarcasm. Our goal is to predict sarcasm in each utterance, using sequential nature of a scene. We show performance gain using sequence labeling as compared to classification-based approaches. Our experiments are based on three sets of features, one is derived from information in our dataset, the other two are from past works. Two sequence labeling algorithms (SVM-HMM and SEARN) outperform three classification algorithms (SVM, Naive Bayes) for all these feature sets, with an increase in F-score of around 4%. Our observations highlight the viability of sequence labeling techniques for sarcasm detection of dialogue.
Cross-Cultural Adaptation, Reliability and Validity of the Chinese Version of the Fear Avoidance Beliefs Questionnaire

The Fear Avoidance Beliefs Questionnaire (FABQ) was translated and cross-culturally adapted for China. Its psychometric properties were then evaluated in Chinese-speaking patients with low-back pain and the scales were tested for internal consistency, reproducibility, ceiling-and-floor effects, construct validity and responsiveness. A total of 15 patients were selected for pre-testing and a further 230 patients completed the FABQ (and other scales) at baseline and 14 days later. A test–retest reliability analysis was carried out on 61 of the 230 patients. The FABQ was found to be easily understood. Explorative factor analysis by principal components analysis, yielded a two-factor model for the FABQ, relating to work and physical activity, and this was confirmed by confirmatory factor analysis using structural equation modelling. The FABQ yielded high values for internal consistency and reproducibility; no ceiling-and-floor effects were detected. Generally, the FABQ scales and baseline variables were weakly correlated. Cohen's effect size was 0.22 and responsiveness was low. It was concluded that the translation and adaptation of the FABQ into Chinese was successful; the scales had acceptable factor structure, internal consistency, test–retest reliability and construct validity.
Lack of Association Between Variations of PDE4D and Ischemic Stroke in the Japanese Population

Background and Purpose— After the first genomewide association study of ischemic stroke identified PDE4D as a susceptible gene, many replication studies have been conducted. However, the validity of the association has remained controversial because of the heterogeneity of both genetic markers and phenotypes. Methods— We investigated the association between variations of PDE4D and ischemic stroke by 3 methods: single-marker, haplotype, and tag-single nucleotide polymorphism (SNP) analyses. In the single-marker analysis, we evaluated the association using 2 large case–control samples (1112 cases and 1112 control subjects in a sample obtained from Kyushu, Japan, and 1711 cases and 1786 control subjects in BioBank Japan) and a prospective cohort with 14 years of follow-up. These samples were analyzed both separately and pooled. Haplotype and tag-SNP analyses were performed using the 2 case–control samples together. Results— In single-marker association tests, we found no significant association in the same direction among the 6 SNP reported in the initial study and ischemic stroke subtypes. Haplotype analysis revealed no significant association between the region around the 5′-end of the gene and combined atherothrombotic and cardioembolic infarction. Rs7730070, a SNP located around the 3′-end of PDE4D, showed the lowest nominal probability value by tag-SNP analysis but was not significant after adjustment for multiple testing (adjusted probability value =0.36). Conclusions— These results suggest that variations in PDE4D are not associated with ischemic stroke risk in the Japanese population.
Association of age and physical exercise with bodyweight and body composition in Asian Chinese men

Background. The present study sought to examine the association between physical exercise as a lifestyle habit with anthropometric parameters and body composition and aging in men. Methods. Intensity of exercise was scored as metabolic equivalent-min/week (MET-min/week) from data of the questionnaire, while anthropometric parameters and body composition were carried out by standard measuring instruments and dual-energy X-ray absorptiometry scanner, respectively. Results. Age was associated with decreases in bodyweight, height, total lean mass and bone mass, but an increase in fat mass. The negative association of lean mass with age was predominantly due to the negative association of lean masses in the legs and arm, while the positive association of fat mass with age was primarily due to the positive association of fat masses in the trunk and abdomen. Exercise of intensity greater than 1000 MET-min/week was significantly associated with higher lean and bone masses and lower fat mass. The increase in lean mass was predominantly in the legs, while the decreases in fat mass were in the trunk and abdomen. Conclusion. The study showed that the high intensity of physical exercise, equivalent to greater than 1000 MET-min/week, is required to effect beneficial changes in the body composition. Hence, results from the study support the importance of promoting a lifestyle habit of exercise of sufficient intensity in order to mitigate the increase risks of sarcopenia and obesity and their attendant ill effects on health in men as they age.
An embedded crack model for failure analysis of concrete solids

We present a quadrilateral fi�nite element with an embedded crack that can be used to model tensile fracture in two-dimensional concrete solids and the crack growth. The element has kinematics that can represent linear jumps in both normal and tangential displacements along the crack line. The cohesive law in the crack is based on rigid-plasticity with soft-ening. The required material data for the concrete failure analysis are the constants of isotropic elasticity and the mode I softening curve. The results of two well known tests are presented in order to illustrate very satisfying performance of the presented approach to simulate failure of concrete solids.
Less than a Single Pass: Stochastically Controlled Stochastic Gradient

We develop and analyze a procedure for gradient-based optimization that we refer to as stochastically controlled stochastic gradient (SCSG). As a member of the SVRG family of algorithms, SCSG makes use of gradient estimates at two scales, with the number of updates at the faster scale being governed by a geometric random variable. Unlike most existing algorithms in this family, both the computation cost and the communication cost of SCSG do not necessarily scale linearly with the sample size $n$; indeed, these costs are independent of $n$ when the target accuracy is low. An experimental evaluation on real datasets confirms the effectiveness of SCSG.
Forty necessary and sufficient conditions for regularity of interval matrices: A survey

This is a survey of forty necessary and sufficient conditions for regularity of interval matrices published in various papers over the last thirty-five years. Afull list of references to the sources of all the conditions is given, and they are commented on in detail. 1. Introduction. During the last thirty-five years (1973-2008), considerable in- terest has been dedicated to the problemof regularity of interval m atrices. It has resulted in formulations of altogether forty necessary and sufficient conditions that constitute the subject matter of this survey paper. By definition, a square interval matrix A is called regular if each A ∈ A is nonsingular, and it is said to be singular otherwise (i.e., if it contains a singular matrix). It is the purpose of this paper to show that this property can be reformulated in surprisingly many surprisingly various ways. In the main Theorem 4.1 we show that regularity of interval matrices can be characterized in terms of determinants (Theorem 4.1, condition (xxxii)), matrix inverses (xxx), linear equations (xxv), absolute value equations (v), absolute value inequalities (ii), matrix equations (xxiv), solvability in each orthant (xvi), inclusions (xxxvii), set properties (xxxvi), real spectral radius (xxxiv), P -matrices (xxix) and edge nonsingularity (xli). We do not include the proof of mutual equivalence of all the conditions since that would make for a very lengthy
Multinational impact of the 1968 Hong Kong influenza pandemic: evidence for a smoldering pandemic.

BACKGROUND The first pandemic season of A/H3N2 influenza virus (1968/1969) resulted in significant mortality in the United States, but it was the second pandemic season of A/H3N2 influenza virus (1969/1970) that caused the majority of deaths in England. We further explored the global pattern of mortality caused by the pandemic during this period. METHODS We estimated the influenza-related excess mortality in 6 countries (United States, Canada, England and Wales, France, Japan, and Australia) using national vital statistics by age for 1967-1978. Geographical and temporal pandemic patterns in mortality were compared with the genetic drift of the influenza viruses by analyzing hemagglutinin and neuraminidase sequences from GenBank. RESULTS In North America, the majority of influenza-related deaths in 1968/1969 and 1969/1970 occurred during the first pandemic season (United States, 70%; Canada, 54%). Conversely, in Europe and Asia, the pattern was reversed: 70% of deaths occurred during the second pandemic season. The second pandemic season coincided with a drift in the neuraminidase antigen. CONCLUSION We found a consistent pattern of mortality being delayed until the second pandemic season of A/H3N2 circulation in Europe and Asia. We hypothesize that this phenomenon may be explained by higher preexisting neuraminidase immunity (from the A/H2N2 era) in Europe and Asia than in North America, combined with a subsequent drift in the neuraminidase antigen during 1969/1970.
Horstschräer , Julia Working Paper Decentralizing university admission : Evidence from a natural experiment

Applying a differences-in-differences strategy, I study the decentralization of university admission as a natural experiment. Is the centralized or decentralized procedure better suited to match prospective students to universities? The analysis uses administrative data on all students within Germany and complements the prominent theoretical literature on college admission. The results show that the matching efficiency increased in course of the decentralization. This increase is mainly driven by enabling law schools to abolish admission restrictions. The matching quality is not significantly affected by the decentralization process but suggests that abolishing admission restrictions could be associated with increasing drop-out rates.
Protein kinase C beta inhibitor prevents diabetic peripheral neuropathy, but not histopathological abnormalities of retina in Spontaneously Diabetic Torii rat

Spontaneously Diabetic Torii (SDT) rat shows severe ocular complications such as tractional retinal detachment. In the present study, effect of protein kinase C beta (PKCβ) inhibitor JTT‐010 was evaluated to clarify the involvement of PKCβ in complications of SDT rat. SDT rats were administered JTT‐010 (10 or 50 mg/kg/day) for 48 weeks. SDT rats showed delayed oscillatory potentials in electroretinogram. Delayed motor nerve conduction velocity, decreased coefficients of variation of R–R intervals in electrocardiogram and thermal hypoalgesia were also observed. These functional disorders were prevented by administration of JTT‐010. Abnormal retinal vascular was formed and the optic disc was protruded in SDT rat; however, JTT‐010 did not prevent these hyperglycaemia‐induced retinal abnormalities. These findings indicate that PKCβ is intimately involved in diabetic complications; however, it seems that other factor(s) are primary contributors to histopathological abnormalities in retina. Therefore, PKCβ inhibitors require concurrent administration of antihyperglycaemic drugs to achieve maximum effect on diabetic complications.
Inhibition of Angiogenesis In Vitro by Chebulagic Acid: A COX-LOX Dual Inhibitor

Angiogenesis is a crucial step in the growth of cancer and its metastasis. It is regulated by several endogenous factors which may stimulate or inhibit the new blood vessel growth. Besides these endogenous factors, several exogenous factors including some natural compounds are known to modulate angiogenesis. Angiogenesis being a potential target for drugs against a number of pathological conditions, search for compounds from natural sources that can affect angiogenesis is of great interest. The objective of our present study was to understand the effect of chebulagic acid, a COX-LOX dual inhibitor isolated from the fruits of Terminalia chebula Retz. , on angiogenesis. The model systems used were rat aortic rings and human umbilical vein endothelial cells. The results showed that chebulagic acid exerts an antiangiogenic effect. This was evidenced from decreased sprouting in rat aortic rings and decrease in biochemical markers in endothelial cells treated with chebulagic acid. It downregulated the production of CD31, E-selectin, and vascular endothelial growth factor in human umbilical vein endothelial cells in culture (HUVEC). Further studies to understand the molecular mechanism of action of chebulagic acid revealed that CA exerts its anti angiogenic effect by modulating VE cadherin-β catenin signalling in human umbilical vein endothelial cells.
Are fish less responsive to a flow stimulus when swimming?

SUMMARY Fish use the lateral line system to sense the water flow created by a predator's strike. Despite its potential importance to the survival of a diversity of species, it is unclear whether this ability becomes compromised when a fish swims. Therefore, the present study compared the behavioral responsiveness of swimming and motionless zebrafish (Danio rerio) larvae when exposed to the flow of a suction-feeding predator. This flow was generated with an impulse chamber, which is a device that we developed to generate a repeatable stimulus with a computer-controlled servo motor. Using high-speed video recordings, we found that about three-quarters (0.76, N=121) of motionless larvae responded to the stimulus with an escape response. These larvae were 66% more likely to respond to flow directed perpendicular than flow running parallel to the body. Swimming larvae exhibited a 0.40 response probability and were therefore nearly half as likely to respond to flow as motionless larvae. However, the latency between stimulus and response was unaffected by swimming or the direction of flow. Therefore, swimming creates changes in the hydrodynamics or neurophysiology of a larval fish that diminish the probability, but not the speed, of their response to a flow stimulus. These findings demonstrate a sensory benefit to the intermittent swimming behavior observed among a broad diversity of fishes.
Socioeconomic status and children with intellectual disability in China.

BACKGROUND Intellectual disability (ID) accounts for 70% of all disabilities among children in China's Second National Sampling Survey on Disability. Although studies have shown a relationship between social class and ID in children, none have investigated the association of socioeconomic variables in Chinese children with mild or severe ID. METHODS Data for children aged 0-6 years with and without ID were abstracted from the Second National Sampling Survey on Disability in China, conducted in 2006. Crude odds ratios showed the effect of sociodemographic factors on mild and severe ID. Adjusted odds ratios (OR(a) ) (95% confidence intervals) estimated the independent effects of these factors. RESULTS For both mild and severe ID, risk of having ID increased with male sex, birth to a woman aged 35 years and older, lower maternal education, mother's older age at delivery, lower income and rural residence. After age, gender and parent disability were controlled, mothers aged 35 years and older were more likely to have a child with ID: mild ID, OR(a) 1.47 (1.15-1.88); severe ID, OR(a) 1.32 (1.00-1.73). There was an approximate increasing monotonic risk of severe ID with increasing socioeconomic disadvantage: lowest income, OR(a) 3.00 (2.19-4.12); low income, OR(a) 2.28 (1.63-3.19); lower middle income, OR(a) 1.72 (1.27-2.33); middle income, OR(a) 1.73 (1.28-2.36). CONCLUSIONS There is a significant relationship between sociodemographic factors and ID. Similar patterns were found for both mild and severe ID. Recommendations are given for preventing ID in Chinese children.
Electrochemical attosyringe

The ability to manipulate ultrasmall volumes of liquids is essential in such diverse fields as cell biology, microfluidics, capillary chromatography, and nanolithography. In cell biology, it is often necessary to inject material of high molecular weight (e.g., DNA, proteins) into living cells because their membranes are impermeable to such molecules. All techniques currently used for microinjection are plagued by two common problems: the relatively large injector size and volume of injected fluid, and poor control of the amount of injected material. Here we demonstrate the possibility of electrochemical control of the fluid motion that allows one to sample and dispense attoliter-to-picoliter (10−18 to 10−12 liter) volumes of either aqueous or nonaqueous solutions. By changing the voltage applied across the liquid/liquid interface, one can produce a sufficient force to draw solution inside a nanopipette and then inject it into an immobilized biological cell. A high success rate was achieved in injections of fluorescent dyes into cultured human breast cells. The injection of femtoliter-range volumes can be monitored by video microscopy, and current/resistance-based approaches can be used to control injections from very small pipettes. Other potential applications of the electrochemical syringe include fluid dispensing in nanolithography and pumping in microfluidic systems.
Reference counting as a computational interpretation of linear logic

Abstract We develop an operational model for a language based on linear logic. Our semantics is ‘low-level’ enough to express sharing and copying while still being ‘high-level’ enough to abstract away from details of memory layout, and thus can be used to test potential applications of linear logic for analysis of programs. In particular, we demonstrate a precise relationship between type correctness for the linear-logic-based language and the correctness of a reference-counting interpretation of the primitives, and formulate and prove a result describing the possible run-time reference counts of values of linear type.
Cardiac magnetic resonance imaging in systemic sclerosis: a cross-sectional observational study of 52 patients

Objectives: To assess the prevalence and patterns of cardiac abnormalities as detected by cardiac magnetic resonance imaging (MRI) in systemic sclerosis (SSc). Methods: Fifty-two consecutive patients with SSc underwent cardiac MRI to determine morphological, functional, perfusion at rest and delayed enhancement abnormalities. Results: At least one abnormality on cardiac MRI was observed in 39/52 patients (75%). Increased myocardial signal intensity in T2 was observed in 6 patients (12%), thinning of left ventricle (LV) myocardium in 15 patients (29%) and pericardial effusion in 10 patients (19%). LV and right ventricle (RV) ejection fractions were altered in 12 patients (23%) and 11 patients (21%), respectively. LV diastolic dysfunction was found in 15/43 patients (35%). LV kinetic abnormalities were found in 16/52 patients (31%) and myocardial delayed contrast enhancement was detected in 11/52 patients (21%). No perfusion defects at rest were found. Patients with limited SSc had similar MRI abnormalities to patients with diffuse SSc. Seven of 40 patients (17%) without pulmonary arterial hypertension had RV dilatation. Conclusions: This study shows that MRI is a reliable and sensitive technique for diagnosing heart involvement in SSc and for analysing its mechanisms, including its inflammatory, microvascular and fibrotic components. Compared with echocardiography, MRI appears to provide additional information by visualising myocardial fibrosis and inflammation. RV dilatation appeared to be non-specific for pulmonary arterial hypertension but could also reflect myocardial involvement related to SSc. Further studies are needed to determine whether cardiac MRI abnormalities have an impact on the prognosis and treatment strategy.
Heart failure disease management programmes: a new paradigm for research

“ The transition from a paradigm in crisis to a new one … changes some of the field's most elementary theoretical generalizations as well as many of its paradigm methods and applications. ”Thomas S Kuhn.1 Few areas of non-pharmacological research have had as much study or success as heart failure disease management programmes (HFDMPs). The first pioneering trial published 17 years ago has been followed by over 60 randomised trials and 15 meta-analyses of home, hospital or telehealth interventions.2 Thirteen of these reviews identified 15%–20% improvements in all-cause mortality, nine identified 30%–56% improvements in HF-related hospitalisation, and 10 identified reductions in all-cause readmission of 15%–25%. 2 Accordingly, guidelines recommended HFDMPs widely and enthusiastically.3 The effectiveness of these non-pharmacological interventions appears assured. Thomas Kuhn famously argued that periods of relative stability in science, known as ‘Normal Science’, are characterised by such consistent successes.1 However, these periods of scientific successes are frequently disturbed by anomalies that cannot be explained using the very approaches that produced past successes.1 Indeed, in recent years, a series of comparatively large and high-quality trials have found no or small benefits from different kinds of HFDMPs.4 Recently, the Medicare Health Support Pilot Program trial of over 250 000 patients achieved only small improvements in a third of the outcomes measured, and identified that commercial disease management programmes for patients …