Miracle-dz/UniFAR-FTUs huggingface dataset:
Temporal Changes in Allocation and Partitioning of New Carbon as 11C Elicited by Simulated Herbivory Suggest that Roots Shape Aboveground Responses in Arabidopsis1[W][OA]

Summary: Radiotracer studies reveal how roots can regulate a plant's defensive responses to insect herbivory. Using the short-lived isotope 11C (t1/2 = 20.4 min) as 11CO2, we captured temporal changes in whole-plant carbon movement and partitioning of recently fixed carbon into primary and secondary metabolites in a time course (2, 6, and 24 h) following simulated herbivory with the well-known defense elicitor methyl jasmonate (MeJA) to young leaves of Arabidopsis (Arabidopsis thaliana). Both 11CO2 fixation and 11C-photosynthate export from the labeled source leaf increased rapidly (2 h) following MeJA treatment relative to controls, with preferential allocation of radiolabeled resources belowground. At the same time, 11C-photosynthate remaining in the aboveground sink tissues showed preferential allocation to MeJA-treated, young leaves, where it was incorporated into 11C-cinnamic acid. By 24 h, resource allocation toward roots returned to control levels, while allocation to the young leaves increased. This corresponded to an increase in invertase activity and the accumulation of phenolic compounds, particularly anthocyanins, in young leaves. Induction of phenolics was suppressed in sucrose transporter mutant plants (suc2-1), indicating that this phenomenon may be controlled, in part, by phloem loading at source leaves. However, when plant roots were chilled to 5°C to disrupt carbon flow between above- and belowground tissues, source leaves failed to allocate resources belowground or toward damaged leaves following wounding and MeJA treatment to young leaves, suggesting that roots may play an integral role in controlling how plants respond defensively aboveground.
Positive Association of the Endothelial Nitric Oxide Synthase Gene Polymorphisms With High-Altitude Pulmonary Edema

Background—A defect of nitric oxide (NO) synthesis in the lung of high-altitude pulmonary edema (HAPE) has been suggested to contribute to its exaggerated pulmonary hypertension. Several polymorphisms have been identified in the gene encoding endothelial nitric oxide synthase (eNOS), which is a key enzyme responsible for NO synthesis, some of which were reported to be associated with vascular disorders. Methods and Results—We studied 41 HAPE-susceptible subjects (HAPE-s) and 51 healthy climbers (control group) in a Japanese population. We examined 2 polymorphisms of the eNOS gene, including the Glu298Asp variant and 27-base pair (bp) variable numbers of tandem repeats using polymerase chain reaction followed by restriction fragment length polymorphism. The Asp allelic frequency of the Glu298Asp variant was 25.6% in the HAPE-s and 9.8% in the controls, which was significantly different between the two groups (P =0.0044). The eNOS4a allelic frequency of 27-bp variable numbers of tandem repeats was 23.2% in the HAPE-s, significantly higher than that of 6.9% in the controls (P =0.0016). In HAPE-s group, 11 of 41 (26.8%) subjects possessed simultaneously both of the two significant alleles, but among the controls, none did, which showed a high statistical difference between the two groups (P =0.000059). Conclusions—Both polymorphisms of the eNOS gene were significantly associated with HAPE. A genetic background may underlie the impaired NO synthesis in the pulmonary circulation of HAPE-s. These polymorphisms could be genetic markers for predicting the susceptibility to HAPE.
Quantum Cost Optimization for Reversible Sequential Circuit

Reversible sequential circuits are going to be the significant memory blocks for the forthcoming computing devices for their ultra low power consumption. Therefore design of various types of latches has been considered a major objective for the researchers quite a long time. In this paper we proposed efficient design of reversible sequential circuits that are optimized in terms of quantum cost, delay and garbage outputs. For this we proposed a new 3*3 reversible gate called SAM gate and we then design efficient sequential circuits using SAM gate along with some of the basic reversible logic gates.
A protocol for packet network intercommunication

A protocol that supports the sharing of resources that exist in different packet switching networks is presented. The protocol provides for variation in individual network packet sizes, transmission failures, sequencing, flow control, end-to-end error checking, and the creation and destruction of logical process-to-process connections. Some implementation issues are considered, and problems such as internetwork routing, accounting, and timeouts are exposed.
Seasonality and weather‐driven variability of transpacific transport

[1] We quantify transport from the industrialized regions of E Asia using the transit-time probability density function, 𝒢, to isolate the role of transport from any other factors, such as chemistry and deposition. Using the offline transport model MATCH driven by NCEP reanalyses, we calculate 𝒢, which is the mass fraction of air that had its last contact with the E-Asian source region during a given day, for each day of a three-year period. Ensemble means of 𝒢 establish the climatological seasonal-mean transport from E Asia. Export from the source region is most efficient in spring, with nearly all E-Asian air involved in transpacific transport. In summer, E-Asian air is transported aloft across the Pacific and, in nearly equal measure, west over SE Asia to the Middle East. Winter transport is similar to that of spring, except winter has low-level transport to SE Asia. Fall transport is intermediate between that of summer and winter. For all seasons, the most probable transit times to N America are 6–8 days in the mid-to-upper troposphere and approximately one week (two for summer) longer at the surface. The surface signal of E-Asian air over N America is strongest in spring. Daily variability of transpacific transport is quantified in terms of the transit-time partitioned burden of E-Asian air over western N America. The standard deviation of the transit-time partitioned fluctuations has a nearly universal dependence on the corresponding seasonal-mean burden. The standard deviation peaks several days before the burden at a transit time of ∼7 days. Lagged event and nonevent composites, based on the western N-American burden of E-Asian air, reveal that transport events are associated with dipolar wind perturbations over the eastern Pacific that are positioned and phased to receive enhanced Asian outflow. Surface-pressure correlations are consistent with an associated strengthened Pacific High and weakened Aleutian Low.
Doctor-patient communication: a comparison of the USA and Japan.

BACKGROUND Little is known about the differences and similarities between doctor-patient communication patterns in different cultures. OBJECTIVES The aim of this study was to examine communication patterns of doctor-patient consultations in two different cultures, namely the USA and Japan, and to elucidate linguistic differences and similarities in communication. METHODS This cross-sectional study used quantitative discourse analysis from linguistics to compare 40 doctor-patient consultations: 20 out-patient consultations of five physicians in the USA and 20 out-patient consultations of four physicians in Japan. The main outcomes measured were time spent in each phase of the encounter, number of categorized speech acts, distribution of question types and frequencies of back-channel responses and interruptions. RESULTS The average length of doctor-patient encounters was 668.7 s in the USA and 505 s in Japan. US physicians spent relatively more time on treatment and follow-up talk (31%) and social talk (12%), whereas the Japanese had longer physical examinations (28%) and diagnosis or consideration talk (15%). Japanese doctor-patient conversations included more silence (30%) than those in the USA (8.2%). The doctor-patient ratios of total speech acts were similar (USA 55% versus 45%; Japan 59% versus 41%). Physicians in both countries controlled communication during encounters by asking more questions than the patients (75% in the USA; 78% in Japan). The Japanese physicians and patients used back-channel responses and interruptions more often than those in the USA. CONCLUSIONS While doctor-patient communication differed between the USA and Japan in the proportion of time spent in each phase of the encounter, length of pauses and the use of back-channel responses and interruptions, physician versus patient ratios of questions and other speech acts were similar. The variations may reflect cultural differences, whereas the similarities may reflect professional specificity stemming from the shared needs to fill the information gap between physician and patient. Adequate awareness of these differences and similarities could be used to educate clinicians about the best approaches to patients from particular cultural backgrounds.
Capacity Results for the Multicast Cognitive Interference Channel

The capacity region of the multicast Cognitive Inter-Ference Channel (CIFC) is investigated. This channel consists of two independent transmitters that wish to multicast two different messages, each to a different set of users. In addition, one of the transmitters—commonly referred to as the cognitive transmitter—has prior non-causal knowledge of both messages to be transmitted. This scenario subsumes some long-standing open problems, such as the <italic>interference channel</italic>, the <italic>broadcast channel</italic>, and <italic>multicast communications</italic>. The aim of this paper is the derivation of optimal interference mitigation techniques under different interference regimes. To this end, two settings, namely the <italic>multi-primary CIFC</italic>, i.e., <inline-formula> <tex-math notation="LaTeX">$M=1$ </tex-math></inline-formula> and <inline-formula> <tex-math notation="LaTeX">$N \geq 1$ </tex-math></inline-formula>, and its complementary, the <italic>multi-secondary CIFC</italic>, i.e., <inline-formula> <tex-math notation="LaTeX">$N=1$ </tex-math></inline-formula> and <inline-formula> <tex-math notation="LaTeX">$M \geq 1$ </tex-math></inline-formula>, are investigated as an attempt to build a thorough understanding for the more general multicast CIFC setting. It is shown that, for some interference regimes, well-known coding techniques for the standard CIFC remain still optimal under the constraint of multicasting to multiple users. However, in other interference regimes, capacity achieving coding and decoding schemes prove to be more involved. A careful combination of these coding schemes and new outer bounding techniques allows to characterize the capacity region for several classes of discrete memoryless and Gaussian multicast CIFC under different interference regimes.
The galanin receptor 2/3 agonist Gal2‐11 protects the SN56 cells against β‐amyloid25–35 toxicity

The neuropeptide galanin is a modulator of cholinergic function and may play a role in Aβ peptide‐induced degeneration of cholinergic forebrain neurons. We have studied the effect of galanin and its galanin receptor subtype 2/3 agonist Gal2‐11on toxicity induced by freshly‐prepared β‐amyloid25–35 in the cholinergic cell line SN56. Both nuclear fragmentation and caspase‐3 expression were analysed. β‐amyloid25–35‐exposure induced a significant increase in caspase‐3 mRNA expression after 30, 60, 90 or 150 min of β‐amyloid25–35 exposure. These effects were abolished in the presence of Gal2‐11 (10 nM). Similarly, β‐amyloid25–35‐induced nuclear fragmentation was prevented by the galanin agonist at all time points studied. These findings indicate that the galanin 2/3 agonist Gal2‐11 protects SN56 cholinergic cells from β‐amyloid25–35‐induced cell death and that this action is mediated by an early reduction of caspase‐3 expression. © 2009 Wiley‐Liss, Inc.
Ultrasound of Muscle Abnormalities

Ultrasound is well suited to evaluate a wide variety of abnormalities involving skeletal muscle, including traumatic injuries, inflammatory or infectious myositis, atrophy, and tumors. Ultrasound can accurately localize and characterize a lesion, or grade the severity of injury. The unique ability of ultrasound to assess the dynamic function of muscles on the real-time or perform Doppler evaluation of vascularity provides insights that are not readily obtained with other imaging modalities. With ultrasound, image-guided biopsy can be performed in conjunction with a diagnostic evaluation. This article presents a pictorial review of lesions and abnormalities involving skeletal muscles, and discusses characteristic findings, classifications, and imaging methods.
Psychopathy, intelligence and emotional responding in a non-forensic sample: an experimental investigation

This study examined the relationships between psychopathy (primary and secondary), intelligence and emotional responding in a sample of 50 university students, using a task measuring autonomic responses to 40 pictorial stimuli (20 neutral and 20 emotionally provoking). Results indicated no significant direct relationship between primary or secondary psychopathy and emotional response, or primary or secondary psychopathy and intelligence. However, a significant moderating effect of intelligence on the association between both psychopathy factors and emotional response was observed, indicating those scoring higher on psychopathy but with lower intelligence portray the expected emotional responses to the affective stimuli (primary: β = −.56, p < .05; secondary: β = .80, p < .001). These findings indicate abnormal reactivity to emotional stimuli in lower intelligence, higher psychopathic individuals, and suggest differing roles for the two facets of psychopathy in affective responsiveness deviations.
Hydro-Adsorption Study by Dynamic Laser Speckle of Natural Zeolite for Adsorbent and Fertilizer Applications

The dynamic behavior caused by hydro-adsorption process of materials based on a rich mineral clinoptilolite together with their acidic, basic and calcinated forms has been studied by the dynamic laser speckle (DLS) technique. We propose a modified Peleg’s equation to improve fitting of DLS data. Textural (BET), structural (XRD) and spectroscopic (FTIR) properties were also studied and compared. We demonstrated that DLS was the most sensitive, simple and inexpensive method for comparing the performance of adsorptive materials with slightly modified surfaces. It also allowed the correlation with physicochemical properties.
On rational series in one variable over certain dioids

We give a characterization of rational series in one variable over certain idempotent semirings (commutative dioids) such as for instance the ``$(\max,+)$ ''semiring. We show that a series is rational iff it is merge of ultimately geometric series. As a by-product, we obtain a new proof of the periodicity theorem for powers of irreducible matrices and also some more general auxiliary results. We apply this characterization of rational series to the minimal realization problem for which we obtain an upper bound. We also obtain a lower bound in terms of minors in a symmetrized semiring
A synthesis of two decades of research documenting the effects of noise on wildlife

Global increases in environmental noise levels – arising from expansion of human populations, transportation networks, and resource extraction – have catalysed a recent surge of research into the effects of noise on wildlife. Synthesising a coherent understanding of the biological consequences of noise from this literature is challenging. Taxonomic groups vary in auditory capabilities. A wide range of noise sources and exposure levels occur, and many kinds of biological responses have been observed, ranging from individual behaviours to changes in ecological communities. Also, noise is one of several environmental effects generated by human activities, so researchers must contend with potentially confounding explanations for biological responses. Nonetheless, it is clear that noise presents diverse threats to species and ecosystems and salient patterns are emerging to help inform future natural resource‐management decisions. We conducted a systematic and standardised review of the scientific literature published from 1990 to 2013 on the effects of anthropogenic noise on wildlife, including both terrestrial and aquatic studies. Research to date has concentrated predominantly on European and North American species that rely on vocal communication, with approximately two‐thirds of the data set focussing on songbirds and marine mammals. The majority of studies documented effects from noise, including altered vocal behaviour to mitigate masking, reduced abundance in noisy habitats, changes in vigilance and foraging behaviour, and impacts on individual fitness and the structure of ecological communities. This literature survey shows that terrestrial wildlife responses begin at noise levels of approximately 40 dBA, and 20% of papers documented impacts below 50 dBA. Our analysis highlights the utility of existing scientific information concerning the effects of anthropogenic noise on wildlife for predicting potential outcomes of noise exposure and implementing meaningful mitigation measures. Future research directions that would support more comprehensive predictions regarding the magnitude and severity of noise impacts include: broadening taxonomic and geographical scope, exploring interacting stressors, conducting larger‐scale studies, testing mitigation approaches, standardising reporting of acoustic metrics, and assessing the biological response to noise‐source removal or mitigation. The broad volume of existing information concerning the effects of anthropogenic noise on wildlife offers a valuable resource to assist scientists, industry, and natural‐resource managers in predicting potential outcomes of noise exposure.
Prediction of Preeclampsia and Delivery of Small for Gestational Age Babies Based on a Combination of Clinical Risk Factors in High-Risk Women

Objective. To develop clinical risk tools for preeclampsia and small for gestational age (SGA) in high-risk women. Methods. Individual risk scores based on clinical risk factors were calculated using logistic regression and validated in 1687 women with obesity in first pregnancy, chronic hypertension, or previous preeclampsia. Results. The risk of preeclampsia varied from 7% in obese primiparae without hypertension to 30% when previous preeclampsia and chronic hypertension occurred together. A prediction model incorporating these risk factors had a sensitivity of 48 and 89% for preeclampsia delivered <34 weeks' gestation. Conclusion. Multiple clinical risk factors increase the risk of preeclampsia and SGA.
Differences between breeds of dog in a measure of heart rate variability

The vasovagal tonus index (VVTI), a time-domain indicator of heart rate variability, was measured in 92 dogs of six breeds (German shepherd dogs, labrador retrievers, cocker spaniels, boxers, bulldogs and cavalier King Charles spaniels). There was a significant difference in VvTi between the six breeds (P=0.003). Brachycephalic dogs had a higher vvTI than other types of dog (P<0.005), and when comparing individual breeds brachycephalic breeds tended to have a higher vvri than non-brachycephalic breeds, although the difference was not always significant. The VVTI was negatively correlated with heart rate (P<0.01) and dogs suffering from congestive heart failure had a lower VVTI than other dogs, whether compared within or between breeds (P<0.001).
Nievergelt-Pearlman syndrome. Synostosis in feet and hands with dysplasia of elbows. Report of a case.

1. A case of massive tarsal synostosis with supination of the forefeet, synostosis in the carpus with brachydactylia, clinicocamptodactylia, symphalangism and dysplasia of the elbows is presented. 2. This conforms to the description by Nievergelt (1944) and Pearlman et al . (1964).
Inhibition of Hepatitis B Virus Replication by cIAP2 Involves Accelerating the Ubiquitin-Proteasome-Mediated Destruction of Polymerase

ABSTRACT Cellular inhibitor of apoptosis protein 2 (cIAP2) is a potent suppressor of apoptotic cell death. We have shown previously that cIAP2 is involved in the tumor necrosis factor alpha (TNF-α)-induced anti-hepatitis B virus (HBV) response; however, the mechanism for this antiviral effect remains unclear. In the present study, we demonstrate that cIAP2 can significantly reduce the levels of HBV DNA replication intermediates but not the total viral RNA or core protein levels. Domain-mapping analysis revealed that the carboxy-terminal domains of cIAP2 were indispensable for this anti-HBV ability and that an E3 ligase-deficient mutant of cIAP2 (termed cIAP2*) completely lost its antiviral activity. We further identified HBV polymerase as the target of cIAP2. Overexpression of cIAP2 but not cIAP2* reduced polymerase protein levels, while cIAP2 knockdown increased polymerase expression. In addition, we observed that cIAP2 promoted the degradation of the viral polymerase through a proteasome-dependent pathway. Further experiments demonstrated that cIAP2 can bind to polymerase and promote its polyubiquitylation. Finally, we found that cIAP2 downregulated the encapsidation of HBV pregenomic RNA. Taken together, these data reveal a novel mechanism for the inhibition of HBV replication by cIAP2 via acceleration of the ubiquitin-proteasome-mediated decay of polymerase and reduction of the encapsidation of HBV pregenomic RNA, making this mechanism a novel strategy for HBV therapy.
Electroconvulsive seizures increase hippocampal neurogenesis after chronic corticosterone treatment

Major depression is often associated with elevated glucocorticoid levels. High levels of glucocorticoids reduce neurogenesis in the adult rat hippocampus. Electroconvulsive seizures (ECS) can enhance neurogenesis, and we investigated the effects of ECS in rats where glucocorticoid levels were elevated in order to mimic conditions seen in depression. Rats given injections of corticosterone or vehicle for 21 days were at the end of this period treated with either a single or five daily ECSs. Proliferating cells were labelled with bromodeoxyuridine (BrdU). After 3 weeks, BrdU‐positive cells in the dentate gyrus were quantified and analyzed for co‐labelling with the neuronal marker neuron‐specific nuclear protein (NeuN). In corticosterone‐treated rats, neurogenesis was decreased by 75%. This was counteracted by a single ECS. Multiple ECS further increased neurogenesis and no significant differences in BrdU/NeuN positive cells were detected between corticosterone‐ and vehicle‐treated rats given five ECS. Approximately 80% of the cells within the granule cell layer and 10% of the hilar cells were double‐labelled with BrdU and NeuN.
A study of birth order, academic performance, and personality

This study aimed to investigate birth order effect on personality and academic performance amongst 120 Malaysians. Besides, it also aimed to examine the relationship between personality and academic achievement. Thirty firstborns, 30 middle children, 30 lastborns, and 30 only children, who shared the mean age of 20.0 years (SD= 1.85), were recruited into this study. Participants’ Sijil Pelajaran Malaysia (SPM) results were recorded and their personality was assessed by Ten Item Personality Inventory (TIPI). Results indicated that participants of different birth positions did not differ significantly in terms of personality and academic performance. However, Pearson’s correlation showed that extraversion correlated positively with academic performance. Keywordsbirth order; personality; academic achievement