Miracle-dz/UniFAR-FTUs huggingface dataset:
Variations of fat tissue fraction in abnormal human bone marrow depend both on size and number of adipocytes: a stereologic study.

Studies dealing with the number or size of individual adipose cells in abnormal human bone marrow are lacking. To ascertain whether variations in fat tissue fraction depend on the size of individual adipocytes or their number or both, a stereologic study of 30 human bone marrow specimens (10 with aplasia, 10 with hyperplasia, and 10 with dysplasia) was performed. A total of 23,435 adipocyte profiles were measured and two stereologic parameters were obtained in each specimen: mean diameter and number of cells per mm3 of bone marrow. The fat tissue fraction correlated positively with the size (r = .79; P less than .001) and the number/volume (r = .77; P less than .001) of adipocytes. The significance of both adipocyte size and adipocyte number/volume was confirmed by stepwise multiple regression, in which the size alone explained 62.5% of fat tissue fraction and both size and number/volume explained 95.8% of fat tissue fraction. These results are discussed from a pathophysiologic point of view.
A Road Less Travelled

This article presents a research framework that understands any management innovation, such as total quality management (TQM), as discursive knowledge that can have certain power effects. It may transform individuals into subjects that secure some sense of their own meaning and identity through participating either as managers or employees in the practices the knowledge embraces. But TQM can also have the opposite effect, resulting in subjects resisting or distancing themselves from, rather than embracing, the discourse. The paper reviews three interpretations of TQM, which are described as rational managerialist, critical control, and processual. It critiques each of these approaches so as to offer an alternative way of understanding TQM, which would also have application to a wide variety of other innovations. In short, it attempts to build upon earlier approaches in the anticipation that we might move beyond our present understanding of innovations such as TQM.
Periodontal conditions among the middle-aged and the elderly in Hong Kong.

The aim of this study was to describe the periodontal conditions in 372 35-44-yr-old and 537 noninstitutionalized 65-74-yr-old Hong Kong Chinese who were examined clinically for loss of attachment, recession, probing depth, calculus, and bleeding after probing. Community Periodontal Index (CPI) data and treatment need indications were compiled from index teeth or their substitutes. The prevalence of loss of attachment varied considerably in both cohorts according to the definition of the threshold (> or = 6, > or = 9, and > or = 12 mm, respectively). The mean numbers of teeth with loss of attachment at the > or = 6-mm threshold and at higher thresholds were small. In both age cohorts, about one-fifth of subjects had probing depths > or = 6-mm, while at the > or = 9-mm threshold only 2-3% were so affected. Although recession was an important component of loss of attachment in the younger cohort, in the older cohort the prevalence and extent of recession were greater than for probing depths at thresholds > or = 4 mm. All subjects had one or more teeth with calculus, bleeding, or both, most teeth being so affected. Eighty-four of the 537 65-74-yr-old subjects were excluded either because of edentulousness or because extractions indicated for the remaining teeth would have rendered the subjects edentulous. The distribution of subjects according to their highest CPI score was remarkably similar for the two cohorts. No subjects in either age group were assessed as "healthy" (CPI code 0) or had "bleeding only" (code 1) as their highest score. While most subjects scored CPI code 2 or 3 as their highest score, only 17% of the younger and 15% of the older cohort scored Community Periodontal Index of Treatment Needs (CPITN) code 4. (ABSTRACT TRUNCATED AT 250 WORDS)
Shaping Science with Rhetoric: The Cases of Dobzhansky, Schrodinger, and Wilson

In considering how scientists persuade colleagues to cross the disciplinary divide, this text examines three scientific monographs in their historical contexts: Dodzhansky's "Genetics and the Origin of Species" (1937); Schrodinger's "What is Life? " (1944); and Wilson's "Consilience" (1998).
The abundance pattern of O, Mg, Si and Fe in the intracluster medium of the Centaurus cluster observed with XMM-Newton

The abundances of 0, Mg, Si, and Fe in the intracluster medium of the Centaurus cluster are derived. The Fe abundance has a negative radial gradient. In solar units, the Si abundance is close to the Fe abundance, while the O and Mg abundances are much lower. The high Fe/O and Si/O ratios indicate that the metal supply from supernovae la is important and that supernovae la synthesize Si as does Fe. Within 2', the O and Mg abundances are consistent with the stellar metallicity of the cD galaxy derived from the Mg 2 index. This result indicates that the central gas is dominated by the gas from the cD galaxy. The observed abundance pattern of the Centaurus cluster resembles those observed in the center of other clusters and groups of galaxies. However, the central Fe abundance and the Si/Fe ratio are 40% higher and 30% lower than those of M 87, respectively. Since the accumulation timescale of the supernovae la is greater in the Centaurus cluster, these differences imply a time dependence of nucleosynthesis by the supernovae la.
A Rare Case of Kikuchi Fujimoto's Disease with Subsequent Development of Systemic Lupus Erythematosus

Kikuchi Fujimoto's disease (KFD) is a rare, immune-mediated, self-limiting disorder with unique histopathological features. KFD is usually seen in young Asian females; however, cases have been reported throughout the world and in all ethnicities. It has been recognized that there is a rare association between Systemic Lupus Erythematosus (SLE) and KFD via sporadic case reports. The exact pathophysiological relationship between these two diseases is still unclear. We report a case of a young Asian female who presented with persistent fever and lymphadenopathy and was diagnosed with Kikuchi Fujimoto's disease based on lymph node biopsy; although an SLE workup was done, she did not meet the American Rheumatology Association (ARA) diagnostic criteria for lupus, and the lymph node biopsy did not show features of SLE. She improved clinically with a short course of steroid therapy. Two months later, the patient presented with central facial rash and arthralgia. SLE workup was repeated, a skin biopsy was done, and the results at this time supported a diagnosis of SLE.
Weak Lensing and Cosmology

We explore the dependence of weak lensing phenomena on the background cosmology. We first generalize the relation between Pψ(ω), the angular power spectrum of the distortion, and the power spectrum of density fluctuations to nonflat cosmologies. We then compute Pψ for various illustrative models. A useful cosmological discriminator is the growth of Pψ with source redshift, which is much stronger in low-matter density models and especially in Λ-dominated models. With even crude redshift information (say from broadband colors), it should be possible to constrain the cosmological world model. The amplitude of Pψ(ω) is also quite sensitive to the cosmology, but requires a reliable external normalization for the mass fluctuations. If one normalizes to galaxy clustering, with M/L fixed by small-scale galaxy dynamics, then low-density models predict a much stronger distortion. If, however, one normalizes to large-scale bulk flows, the predicted distortion for sources at redshifts Zs ~ 1-3 is rather insensitive to the background cosmology. The signals predicted here can be detected at a very high level of significance with a photometric survey covering, say, 10 deg2, but sparse sampling is needed to avoid large sampling variance. We discuss the factors influencing the design of an optimum survey. Turning to weak lensing by clusters, we find that for high lens redshifts (Zl ≃ 1) the critical density is substantially reduced in Λ-models, but that the ratio of the shear or convergence to the velocity dispersions or X-ray temperature of clusters is only very weakly dependent on the cosmology.
Improvement in outcome for children receiving allogeneic bone marrow transplantation in first remission of acute myeloid leukemia: a report from the Groupe d'Etude des Greffes de Moelle Osseuse.

PURPOSE We retrospectively analyzed the outcome of children with acute myeloid leukemia (AML) in first complete remission (CR) who received HLA-identical bone marrow transplantation (BMT) in 13 French transplant centers. PATIENTS AND METHODS Seventy-four children were treated from June 1979 through December 1990. The conditioning regimen included total-body irradiation (TBI) in 54 cases and busulfan in 20. Prophylaxis of graft-versus-host disease (GVHD) consisted of cyclosporine (CycloA) plus methotrexate (MTX) for 38 patients, MTX for 17, CycloA for 18, and T depletion without other prophylaxis for one. The mean value of the interval from diagnosis to transplantation was 167 days. RESULTS Sixteen patients died of transplant-related complications, 12 relapsed, and 46 are alive in continuous remission with a median follow-up of 46 months. We examined results obtained over three successive periods: 1979 to 1982 (n = 14 children), 1983 to 1986 (n = 29), and 1987 to 1990 (n = 31). Probabilities of event-free survival (EFS) were 43%, 48%, and 82% for the three successive periods, respectively (P < .02). This improvement in EFS was linked to a decreased risk of transplant-related mortality: 36%, 36%, and 3%, respectively (P < .01). Other factors associated with a better EFS in the univariate analysis were a short time interval from diagnosis to transplant (< 120 days), the absence of significant (grade > or = 2) acute GVHD, and the absence of chronic GVHD. In the multivariate analysis, two factors had a favorable impact on long-term survival: the year of transplantation (years 1987 to 1990 v others) and the absence of acute GVHD. CONCLUSION The outcome for children receiving allogeneic BMT in first CR of AML has improved in France during recent years.
Big boys don't cry : understanding barriers to seeking support for mental health problems among adolescent males

This study explored the possible barriers encountered by adolescents in developing and achieving positive mental health. Male adolescents in Perth, Western Australia were consulted in an attempt to provide insight into the motivating and inhibiting factors influencing help-seeking as a coping strategy. Barriers to seeking help for mental health problems were investigated through the inductive process of grounded theory (Glaser & Strauss, 1967) to obtain a more detailed understanding of help-seeking than previous studies have provided. The study found that the coping responses most frequently enacted by the adolescent males sampled included avoidance, diversion, and private resolution. Help-seeking was far less frequently enacted, and was suggested to be the course of last resort. The primary barrier to help-seeking was found to be the interviewees' fear of feeling and appearing incompetent in successfully enacting the traditional male role. This primary barrier appeared to stem from the interviewees' socialised perceptions of the ideal male, their perceptions of available help-sources, and their perceptions of those with mental ill-health. These factors thus constitute possible barriers faced by male adolescents in achieving positive mental health and provide insights into key areas that need to be addressed in social marketing strategies. In addition, practical information and recommendations are directed towards adolescents, parents, and educators.
Fourier Sparsity, Spectral Norm, and the Log-Rank Conjecture

We study Boolean functions with sparse Fourier spectrum or small spectral norm, and show their applications to the Log-rank Conjecture for XOR functions f(x ⊕ y) - a fairly large class of functions including well studied ones such as Equality and Hamming Distance. The rank of the communication matrix M<sub>f</sub> for such functions is exactly the Fourier sparsity of f. Let d = deg<sub>2</sub>(f) be the F<sub>2</sub>-degree of f and DCC(f · ⊕) stand for the deterministic communication complexity for f(x ⊕ y). We show that 1) DCC(f · ⊕) = O(2<sup>d2/2</sup> log<sup>d-</sup>2 ∥f̂∥<sub>1</sub>). In particular, the Log-rank conjecture holds for XOR functions with constant F<sub>2</sub>-degree. 2) D<sup>CC</sup>(f · ⊕) = O(d∥f̂∥<sub>1</sub>) = O(√(rank(M<sub>f</sub>))). This improves the (trivial) linear bound by nearly a quadratic factor. We obtain our results through a degree-reduction protocol based on a variant of polynomial rank, and actually conjecture that the communication cost of our protocol is at most log<sup>O(1)</sup> rank(M<sub>f</sub>). The above bounds are obtained from different analysis for the number of parity queries required to reduce f's F<sub>2</sub>-degree. Our bounds also hold for the parity decision tree complexity of f, a measure that is no less than the communication complexity. Along the way we also prove several structural results about Boolean functions with small Fourier sparsity ∥f̂∥<sub>0</sub> or spectral norm ∥f̂∥<sub>1</sub>, which could be of independent interest. For functions f with constant F<sub>2</sub>-degree, we show that: 1) f can be written as the summation of quasi-polynomially many indicator functions of subspaces with ±-signs, improving the previous doubly exponential upper bound by Green and Sanders; 2) being sparse in Fourier domain is polynomially equivalent to having a small parity decision tree complexity; and 3) f depends only on polylog∥f̂∥<sub>1</sub> linear functions of input variables. For functions f with small spectral norm, we show that: 1) there is an affine subspace of co dimension ∥f̂∥<sub>1</sub> on which f(x) is a constant, and 2) there is a parity decision ∥f̂∥<sub>1</sub>log∥f̂∥<sub>0</sub> for computing f.
SRSF6-regulated alternative splicing that promotes tumour progression offers a therapy target for colorectal cancer

Objective To investigate the molecular function of splicing factor SRSF6 in colorectal cancer (CRC) progression and discover candidate chemicals for cancer therapy through targeting SRSF6. Design We performed comprehensive analysis for the expression of SRSF6 in 311 CRC samples, The Cancer Genome Atlas and Gene Expression Omnibus (GEO) database. Functional analysis of SRSF6 in CRC was performed in vitro and in vivo. SRSF6-regulated alternative splicing (AS) and its binding motif were identified by next-generation RNA-sequencing and RNA immunoprecipitation sequencing (RIP-seq), which was validated by gel shift and minigene reporter assay. ZO-1 exon23 AS was investigated to mediate the function of SRSF6 in vitro and in vivo. Based on the analysis of domain-specific role, SRSF6-targeted inhibitor was discovered de novoby virtual screening in 4855 FDA-approved drugs and its antitumour effects were evaluated in vitroand in vivo. Results SRSF6 was frequently upregulated in CRC samples and associated with poor prognosis, which promoted proliferation and metastasis in vitro and in vivo. We identified SRSF6-regulated AS targets and discovered the SRSF6 binding motif. Particularly, SRSF6 regulates ZO-1 aberrant splicing to function as an oncogene by binding directly to its motif in the exon23. Based on the result that SRSF6 RRM2 domain plays key roles in regulating AS and biological function, indacaterol, a β2-adrenergic receptor agonist approved for chronic obstructive pulmonary disease treatment, is identified as the inhibitor of SRSF6 to suppress CRC tumourigenicity. Conclusions SRSF6 functions the important roles in mediating CRC progression through regulating AS, and indacaterol is repositioned as an antitumour drug through targeting SRSF6. Accession numbers The accession numbers for sequencing data are SRP111763 and SRP111797.
Characterization of Differentiation of Bovine Mammary Epithelial Cells

2 Acknowledgements 3 Review of Literature Introduction 5 Development of the Mammary Gland 5 Mammary Epithelial Cells (MEC) 11 Caseins 13 Growth Hormone 15 Rationale 16 Materials and Methods Excising Tissue From Bovine Mammary Gland 18 Isolation of Primary MEC 18 Cell Culture 19 Removal of Fibroblast Cells 20 Differentiation of MEC 20 Results 22 Figures 23 Discussion 26 Conclusion 30 References 31
Holomorphic disks and three-manifold invariants: Properties and applications

In [27], we introduced Floer homology theories HF - (Y,s), HF∞(Y,s), HF + (Y, t), HF(Y,s),and HF red (Y, s) associated to closed, oriented three-manifolds Y equipped with a Spiny structures s ∈ Spin c (Y). In the present paper, we give calculations and study the properties of these invariants. The calculations suggest a conjectured relationship with Seiberg-Witten theory. The properties include a relationship between the Euler characteristics of HF ± and Turaev's torsion, a relationship with the minimal genus problem (Thurston norm), and surgery exact sequences. We also include some applications of these techniques to three-manifold topology.
Positive and Negative Circuits in Dynamical Systems

We state precisely and demonstrate two conjectures of R. Thomas following which (a) the existence of a positive circuit in the oriented interaction graph of a differential system is a necessary condition for the existence of several steady states, and (b) the existence of a negative non-oriented circuit of length at least two is a necessary condition for the existence of a stable periodic orbit.
Functional Heterogeneity within the Default Network during Semantic Processing and Speech Production

This fMRI study investigated the functional heterogeneity of the core nodes of the default mode network (DMN) during language processing. The core nodes of the DMN were defined as task-induced deactivations over multiple tasks in 94 healthy subjects. We used a factorial design that manipulated different tasks (semantic matching or speech production) and stimuli (familiar words and objects or unfamiliar stimuli), alternating with periods of fixation/rest. Our findings revealed several consistent effects in the DMN, namely less deactivations in the left inferior parietal lobule during semantic than perceptual matching in parallel with greater deactivations during semantic matching in anterior subdivisions of the posterior cingulate cortex (PCC) and the ventromedial prefrontal cortex (MPFC). This suggests that, when the brain is engaged in effortful semantic tasks, a part of the DMN in the left angular gyrus was less deactivated as five other nodes of the DMN were more deactivated. These five DMN areas, where deactivation was greater for semantic than perceptual matching, were further differentiated because deactivation was greater in (i) posterior ventral MPFC for speech production relative to semantic matching, (ii) posterior precuneus and PCC for perceptual processing relative to speech production, and (iii) right inferior parietal cortex for pictures of objects relative to written words during both naming and semantic decisions. Our results thus highlight that task difficulty alone cannot fully explain the functional variability in task-induced deactivations. Together these results emphasize that core nodes within the DMN are functionally heterogeneous and differentially sensitive to the type of language processing.
Mindfulness and Schema Therapy: A Practical Guide

Group Schema Therapy for Borderline Personality DisorderBreaking Negative Thinking PatternsCognitive Behavior Therapy of DSM-5 Personality DisordersContextual Schema TherapySchema TherapySchema Therapy with CouplesHandbook of Cognitive-Behavioral Therapies, Fourth EditionAcceptance and Commitment Therapy for CouplesHandbook of Cognitive-Behavioral Therapies, Third EditionMindfulness and Schema TherapyDisarming the NarcissistAcceptance and Mindfulness in Cognitive Behavior TherapyEmotional Schema TherapySchema TherapyExperiencing Schema Therapy from the Inside OutIntegrating CBT and Third Wave TherapiesWorking with Emotion in Cognitive-Behavioral TherapyThe Mindful Menopause WorkbookThe Therapeutic Relationship in Cognitive Behavioural TherapyLove Me, Don't Leave MeSchema TherapyBreaking Negative Relationship PatternsThe Schema Therapy Clinician's GuideNo More Narcissists! Schema Therapy for Eating DisordersCognitive Therapy for Personality DisordersMindfulness e schema therapy. Guida praticaSchema Therapy in PracticeMindfulness and Schema TherapySchema Therapy for Borderline Personality DisorderEmotional Schema TherapyAcceptance and Commitment Therapy for Interpersonal ProblemsEmotional AlchemyMindfulness for TherapistsReinventing Your LifeThe Wiley-Blackwell Handbook of Schema TherapyThe Interpersonal Problems WorkbookThe Application of the Third Generation of Cognitive-Behavioral Approaches to ParentingEveryday Mindfulness for OCDMindfulness-Based Cognitive Therapy for Depression, Second Edition
Effect of COD/SO ratio on anaerobic treatment of landfill leachate during the start-up period

This study investigates the performance of an anaerobic baffled reactor (ABR) during the start-up period of raw young landfill leachate treatment at two chemical oxygen demand (COD) to SO ratios of 20 and 4. The reactor was operated at ambient temperature and low organic loading rates (0.52, 0.76 and 1.05 kg COD/m3 per day). During the study, sulfate-reducing bacteria (SRB) activity increased at the lower ratio of COD/SO producing higher levels of sulfide and alkalinity. The dissolved sulfide concentration reached an inhibitory level above 250 mg/L, which caused a sharp reduction in the total COD removal efficiency from 77–80% to 32%. Total volatile fatty acid (TVFA) production proceeded at a constant level despite increased organic loading. As the effluent total and organic COD concentrations increased, the inhibitory effect of the inborn sulfide was correlated to the limitation experienced in the hydrolysis/acidogenesis stages, and thus VFA production and organic matter removal.
Application of inter simple sequence repeat (ISSR) markers to plant genetics

Microsatellites or simple sequence repeats (SSRs) are ubiquitous in eukaryotic genomes. Single‐locus SSR markers have been developed for a number of species, although there is a major bottleneck in developing SSR markers whereby flanking sequences must be known to design 5′‐anchors for polymerase chain reaction (PCR) primers. Inter SSR (ISSR) fingerprinting was developed such that no sequence knowledge was required. Primers based on a repeat sequence, such as (CA)n, can be made with a degenerate 3′‐anchor, such as (CA)8RG or (AGC)6TY. The resultant PCR reaction amplifies the sequence between two SSRs, yielding a multilocus marker system useful for fingerprinting, diversity analysis and genome mapping. PCR products are radiolabelled with 32P or 33P via end‐labelling or PCR incorporation, and separated on a polyacrylamide sequencing gel prior to autoradiographic visualisation. A typical reaction yields 20–100 bands per lane depending on the species and primer. We have used ISSR fingerprinting in a number of plant species, and report here some results on two important tropical species, sorghum and banana. Previous investigators have demonstrated that ISSR analysis usually detects a higher level of polymorphism than that detected with restriction fragment length polymorphism (RFLP) or random amplified polymorphic DNA (RAPD) analyses. Our data indicate that this is not a result of greater polymorphism genetically, but rather technical reasons related to the detection methodology used for ISSR analysis.