Miracle-dz/UniFAR-FTUs huggingface dataset:
The Effect of Walnut Oil Consumption on Blood Sugar in Patients With Diabetes Mellitus Type 2

Background Prevalence of diabetes mellitus type 2 (DM) is increasing globally. Considering the potential role of poly-unsaturated fatty acids in prevention of DM type 2 and lipid profiles improvement, some studies have been carried out on walnut. However, there are no studies on control of blood sugar in DM type 2 patients using walnut. Objectives The current study aimed to evaluate the effect of walnut oil on blood sugar in DM type 2 patients. Methods This randomized control clinical trial was performed on 100 patients with DM type 2. For the experiment group (n = 50), walnut oil (15 g/day for three months) was added to their diet, while the control group (n = 50) did not undergo any interventions. Before initiation of the experiment and after the experiment, the systolic and diastolic blood pressure (SBP and DBP) levels, fasting blood sugar (FBS) and HbA1c were measured. Results The two groups were not significantly different for SBP, DBP, body weight, and Body Mass Index. HbA1c level decreased significantly in the experiment group by 7.86% ± 21.97 (P = 0.005) from 7.00 ± 1.08 before the intervention to 6.37 ± 1.29 after the intervention. Also, FBS level decreased significantly by 8.24% ± 16.77 (P = 0.001); from 158.37 ± 48.16 before the intervention to 137.91 ± 23.24 after the intervention in the experimental group. These changes in the control group were not significant. Conclusions Consumption of walnut oil (15 g/day for three months) was shown to improve blood glucose level but, no changes were noted for bodyweight and blood pressure in type two diabetic patients.
Vitamin D3-dependent VDR signaling delays ron-mediated breast tumorigenesis through suppression of β-catenin activity

The Ron receptor is upregulated in human breast cancers and correlates with enhanced metastasis and reduced patient survival. Ron overexpression drives mammary tumorigenesis through direct β-catenin activation and augmented tumor cell proliferation, migration and invasion. Ron and β-catenin are also coordinately elevated in breast cancers. The vitamin D receptor (VDR) antagonizes β-catenin signaling. Herein, we examined mammary tumor onset and progression using a Ron-driven murine model of breast tumorigenesis crossed with VDR deficient mice. VDR ablation accelerated mammary tumor onset and led to tumors that exhibited a desmoplastic phenotype and enhanced metastases. Tumor levels of active β-catenin were markedly increased in the absence of VDR. In vitro, VDR activation in breast cancer cells reduced β-catenin activation and transcriptional activity leading to elevated expression of the extracellular Wnt inhibitor dickkopf-related protein 1, and a reduction in the interaction of β-catenin with the cyclin D1 promoter. Expression of a stabilized form or β-catenin ablated the protective effects of VDR activation. Collectively, these studies delineate a protective role for VDR signaling in Ron-induced mammary tumorigenesis through disruption of β-catenin activation.
Picture-based persuasion in advertising: the impact of attractive pictures on verbal ad’s content

The present study aims to further examine the persuasive effect of pictures in a print ad according to the recipient’s ability to process the information and to observe to what extent the presence of a picture could negatively influence recipients’ attitude toward the ad’s verbal claim. ,Two studies were designed to manipulate the presence vs absence of an attractive/unattractive picture, the kind of verbal claims (affectively based vs rationally based) and the recipient’s ability to process the ad (cognitive load vs no cognitive load). ,Main findings showed that the presence of an attractive picture elicited an unfavorable attitude toward the functional verbal claim when recipients were not cognitively charged. Furthermore, it proved to be a mediator of the influence of pictures on attitude toward the ad. The positive influence of an attractive picture on product evaluation and purchase intention was greater under a cognitive load but showed contrasting results for price perceptions. For the unattractive picture, cognitive load was found to be a moderator only when recipients had to infer the product price. ,The present research emphasized the negative influence of attractive pictures on functional verbal claims and the moderating role of cognitive load on pictorial stimuli either acting as peripheral or central cues in the persuasive process. ,Practitioners may want to consider that an attractive picture in advertising is not always the best route for persuasion, especially when the verbal ad content emphasizes the product’s properties. ,The present study provides new insights regarding the role of pictures in advertising persuasive effectiveness. Until now, no research had addressed the extent to which the presence of a picture could affect processing of an ad’s verbal claims. Additionally, the present study expands research on persuasive communication and affirms the necessity of more intensively investigating the role of pictures in advertising under the rubric of information processing level.
Opinion dynamics using Altafini's model with a time-varying directed graph

Distributed control policies (or protocols) for multi-agent consensus have been extensively studied in recent years, motivated by numerous applications in engineering and science. Most of these algorithms assume the agents to be mutually cooperative and “trustful” and correspondingly attractive couplings between the agents bring the values of the agents' states closer. Opinion dynamics of real social groups, however, require beyond conventional models of multi-agent consensus due to ubiquitous competition and distrust between some pairs of agents, which are usually characterized by the repulsive cou-pling. Antagonistic interactions prevent the averaging tendency of the opinions, which cooperative consensus protocols promote, and may lead to their polarization and clustering. A simple yet insightful model of opinion dynamics with both attractive and repulsive couplings was proposed recently by C. Altafini, who examined first-order consensus algorithms over static signed interaction graphs, where arcs of positive weights connect cooperating agents, and of negative weights correspond to antagonistic pairs. This protocol establishes modulus consensus, where the opinions become the same in modulus but may differ in sign. In the present paper, we extend the modulus consensus model to the case where the network topology is arbitrary time-varying, directed, signed graph. We show that under mild condition of uniform strong connectivity of the network, the protocol establishes agreement of opinions in moduli, whose signs may be opposite, so that the agents' opinions either reach consensus or polarize. This result is further extended to nonlinear consensus protocols. We show also that, unlike cooperative consensus algorithms, uniform strong connectivity cannot be relaxed to uniform quasi-strong connectivity (UQSC).
Universal function-specificity of codon usage

Synonymous codon usage has long been known as a factor that affects average expression level of proteins in fast-growing microorganisms, but neither its role in dynamic changes of expression in response to environmental changes nor selective factors shaping it in the genomes of higher eukaryotes have been fully understood. Here, we propose that codon usage is ubiquitously selected to synchronize the translation efficiency with the dynamic alteration of protein expression in response to environmental and physiological changes. Our analysis reveals that codon usage is universally correlated with gene function, suggesting its potential contribution to synchronized regulation of genes with similar functions. We directly show that coexpressed genes have similar synonymous codon usages within the genomes of human, yeast, Caenorhabditis elegans and Escherichia coli. We also demonstrate that perturbing the codon usage directly affects the level or even direction of changes in protein expression in response to environmental stimuli. Perturbing tRNA composition also has tangible phenotypic effects on the cell. By showing that codon usage is universally function-specific, our results expand, to almost all organisms, the notion that cells may need to dynamically alter their intracellular tRNA composition in order to adapt to their new environment or physiological role.
Model-independent diagnostics of highly reddened Milky Way star clusters: age calibration

Context. The next generation near- and mid-infrared Galactic surveys will yield a large number of new highly obscured star clusters. Detailed characterization of these new objects with spectroscopy is time-consuming. Aims. Diagnostic tools that will be able to characterize clusters based only on the available photometry will be needed to study large samples of the newly found objects. Methods. The brightness difference between the red clump and the main-sequence turn-off point have been used as a model-independent age calibrator for clusters with ages from a few 10 8 to 10 10 yr in the optical. Here we apply for the first time the method in the near-infrared. Results. We calibrated this difference in K -band, which is likely to be available for obscured clusters, and we apply it to a number of test clusters with photometry comparable to the one that will be yielded by the current or near-future surveys. Conclusions. The new calibration yields reliable ages over the range of ages for which the red clump is present in clusters. The slope of the relation is smoother than that of the corresponding V -band relation, reducing the uncertainty in the age determinations with respect to the optical ones.
The Distinct Gene Regulatory Network of Myoglobin in Prostate and Breast Cancer

Myoglobin (MB) is not only strongly expressed in myocytes, but also at much lower levels in different cancer entities. 40% of breast tumors are MB-positive, with the globin being co-expressed with markers of tumor hypoxia in a proportion of cases. In breast cancer, MB expression is associated with a positive hormone receptor status and patient prognosis. In prostate cancer, another hormone-dependent cancer type, 53% of tumors were recently shown to express MB. Especially in more aggressive prostate cancer specimen MB expression also correlates with increased patient survival rates. Both findings might be due to tumor-suppressing properties of MB in cancer cells. In contrast to muscle, MB transcription in breast and prostate cancer mainly depends on a novel, alternative promoter site. We show here that its associated transcripts can be upregulated by hypoxia and downregulated by estrogens and androgens in MCF7 breast and LNCaP prostate cancer cells, respectively. Bioinformatic data mining of epigenetic histone marks and experimental verification reveal a hitherto uncharacterized transcriptional network that drives the regulation of the MB gene in cancer cells. We identified candidate hormone-receptor binding elements that may interact with the cancer-associated MB promoter to decrease its activity in breast and prostate cancer cells. Additionally, a regulatory element, 250 kb downstream of the promoter, acts as a hypoxia-inducible site within the transcriptional machinery. Understanding the distinct regulation of MB in tumors will improve unraveling the respiratory protein’s function in the cancer context and may provide new starting points for developing therapeutic strategies.
Inter-cell coordination with inhomogeneous traffic distribution

We study the optimal division of cells into different service areas served under different coordinated transmission modes, i.e. combinations of base stations simultaneously transmitting, in order to avoid the adverse effect of inter-cell interference and to maximize the system capacity. We focus on the general case where the traffic load is inhomogeneous and give a complete characterization of the optimum for two-cell and three-cell systems in terms of a set of necessary conditions. An example of a three-cell system with a traffic load having a gradient in an arbitrary direction is numerically worked out
Unmasking Motion-Processing Activity in Human Brain Area V5/MT+ Mediated by Pathways That Bypass Primary Visual Cortex

Most models of the human visual system argue that higher-order motion-processing cortical regions receive their inputs only via the primary visual cortex (striate cortex), rather than also via direct projections from the thalamus that bypass primary visual cortex. However, recent evidence in non-human primates, along with some evidence in humans with damaged primary visual cortex (e.g., "blindsight" for motion in the blind visual hemifield), have argued for the existence of a direct thalamic-to-extrastriate projection for motion processing. This evidence remains controversial. Here we tested the idea that direct thalamic input to extrastriate motion processing areas exists in humans but might be masked in scalp recordings by activity from early visual areas. To do this, we employed stimuli that induced strong refractory effects in primary visual cortex--thereby creating a brief "reversable lesion" in primary visual cortex--immediately before the presentation of a motion stimulus. Under these conditions, we then assessed whether motion areas of cortex were still able to process the motion stimuli by recording event-related potentials (ERPs) and event-related magnetic fields (ERFs/MEG). We found robust motion-related activity in extrastriate motion processing areas in the ERP and MEG signals even when primary visual cortex was heavily suppressed by our manipulation. This finding provides evidence for a direct thalamic functional pathway to extrastriate visual cortical motion processing areas in the human that bypasses primary visual cortex.
Bacterial Communities of Two Ubiquitous Great Barrier Reef Corals Reveals Both Site- and Species-Specificity of Common Bacterial Associates

Background Coral-associated bacteria are increasingly considered to be important in coral health, and altered bacterial community structures have been linked to both coral disease and bleaching. Despite this, assessments of bacterial communities on corals rarely apply sufficient replication to adequately describe the natural variability. Replicated data such as these are crucial in determining potential roles of bacteria on coral. Methodology/Principal Findings Denaturing Gradient Gel Electrophoresis (DGGE) of the V3 region of the 16S ribosomal DNA was used in a highly replicated approach to analyse bacterial communities on both healthy and diseased corals. Although site-specific variations in the bacterial communities of healthy corals were present, host species-specific bacterial associates within a distinct cluster of gamma-proteobacteria could be identified, which are potentially linked to coral health. Corals affected by “White Syndrome” (WS) underwent pronounced changes in their bacterial communities in comparison to healthy colonies. However, the community structure and bacterial ribotypes identified in diseased corals did not support the previously suggested theory of a bacterial pathogen as the causative agent of the syndrome. Conclusions/Significance This is the first study to employ large numbers of replicated samples to assess the bacterial communities of healthy and diseased corals, and the first culture-independent assessment of bacterial communities on WS affected Acroporid corals on the GBR. Results indicate that a minimum of 6 replicate samples are required in order to draw inferences on species, spatial or health-related changes in community composition, as a set of clearly distinct bacterial community profiles exist in healthy corals. Coral bacterial communities may be both site and species specific. Furthermore, a cluster of gamma-proteobacterial ribotypes may represent a group of specific common coral and marine invertebrate associates. Finally, the results did not support the contention that a single bacterial pathogen may be the causative agent of WS Acroporids on the GBR.
Firm training and wage rigidity

Although wage rigidity is among the most prominent subjects in modern economics, its effects on wage compression and firm training have thus far not been considered. This paper is trying to bridge this gap by using a simple two period model which can still by analyzed analytically. I am able to show that wage rigidity increases wage compression. However, contrary to previous work this is not sufficient to increase firms' training investments. The reason lies in the endogeneity of separations, which become more frequent.
Radiological Assessment of Bioengineered Bone in a Muscle Flap for the Reconstruction of Critical-Size Mandibular Defect

This study presents a comprehensive radiographic evaluation of bone regeneration within a pedicled muscle flap for the reconstruction of critical size mandibular defect. The surgical defect (20 mm×15 mm) was created in the mandible of ten experimental rabbits. The masseter muscle was adapted to fill the surgical defect, a combination of calcium sulphate/hydroxyapatite cement (CERAMENT™ |SPINE SUPPORT), BMP-7 and rabbit mesenchymal stromal cells (rMSCs) was injected inside the muscle tissue. Radiographic assessment was carried out on the day of surgery and at 4, 8, and 12 weeks postoperatively. At 12 weeks, the animals were sacrificed and cone beam computerized tomography (CBCT) scanning and micro-computed tomography (µ-CT) were carried out. Clinically, a clear layer of bone tissue was identified closely adherent to the border of the surgical defect. Sporadic radio-opaque areas within the surgical defect were detected radiographically. In comparison with the opposite non operated control side, the estimated quantitative scoring of the radio-opacity was 46.6% ±15, the mean volume of the radio-opaque areas was 63.4% ±20. Areas of a bone density higher than that of the mandibular bone (+35% ±25%) were detected at the borders of the surgical defect. The micro-CT analysis revealed thinner trabeculae of the regenerated bone with a more condensed trabecular pattern than the surrounding native bone. These findings suggest a rapid deposition rate of the mineralised tissue and an active remodelling process of the newly regenerated bone within the muscle flap. The novel surgical model of this study has potential clinical application; the assessment of bone regeneration using the presented radiolographic protocol is descriptive and comprehensive. The findings of this research confirm the remarkable potential of local muscle flaps as local bioreactors to induce bone formation for reconstruction of maxillofacial bony defects.
An RNA biosensor for imaging the first round of translation from single cells to living animals

Measuring translation in space and time The ribosome translates the information contained within messenger RNAs (mRNAs) into proteins. When and where ribosomes encounter mRNAs can regulate gene expression. Halstead et al. developed an RNA biosensor that allows single molecules of mRNAs that have never been translated to be distinguished from ones that have undergone translation by the ribosome in living cells (see the Perspective by Popp and Maquat). The authors demonstrated the utility of their technique by examining the spatial and temporal regulation of translation in single cells and in Drosophila oocytes during development. Science, this issue p. 1367; see also p. 1316 Engineered reporters visualize the translation of single molecules of messenger RNA in living cells. [Also see Perspective by Popp and Maquat] Analysis of single molecules in living cells has provided quantitative insights into the kinetics of fundamental biological processes; however, the dynamics of messenger RNA (mRNA) translation have yet to be addressed. We have developed a fluorescence microscopy technique that reports on the first translation events of individual mRNA molecules. This allowed us to examine the spatiotemporal regulation of translation during normal growth and stress and during Drosophila oocyte development. We have shown that mRNAs are not translated in the nucleus but translate within minutes after export, that sequestration within P-bodies regulates translation, and that oskar mRNA is not translated until it reaches the posterior pole of the oocyte. This methodology provides a framework for studying initiation of protein synthesis on single mRNAs in living cells.
The Effect of Therapy Dogs on Exam Stress and Memory

ABSTRACT Therapy dogs have been shown in many different situations to reduce stress and improve outcomes, but their effects on academic performance are unknown. I hypothesized that interaction with therapy dogs prior to exams would reduce stress in students and improve exam scores. In study 1, participants who chose to interact with the therapy dogs showed a significantly larger stress decrease and scored 5.5 points higher on their final exam than those who did not interact. In study 2, investigating memory retrieval, participants assigned to interact with therapy dogs immediately prior to their final exam showed a marginally larger stress reduction, but no difference in exam score, compared with those who watched a movie about dogs. To investigate memory consolidation, in study 3, participants were assigned to interact with therapy dogs or watch a movie immediately after learning some material. A significant interaction between condition and exam question type suggests that, compared with those who watched a movie about dogs, interacting with therapy dogs impaired memory for material learned just prior to the manipulation, but enhanced memory for material encountered at other times. Overall, interaction with therapy dogs appears to reduce stress, but had no effect on memory retrieval in study 2, and differentially affected memory consolidation of associated material in study 3.
Evaluation of the effectiveness of highly active antiretroviral therapy in persons with human immunodeficiency virus using biomarker-based equivalence of disease progression.

The association of different CD4(+) cell counts with the same disease risk in treated and untreated populations reflects the effectiveness of highly active antiretroviral therapy (HAART) in persons with human immunodeficiency virus (HIV). Clinical progression of disease following initiation of HAART was determined for 679 HIV-infected men in the Multicenter AIDS Cohort Study by means of Kaplan-Meier survival analyses. Cox proportional hazards models were used to assess the effects of markers of HIV disease, antiretroviral history, and demographic factors. Men who had been followed since January 1993 (pre-HAART) were used to identify CD4(+) levels associated with the acquired immunodeficiency syndrome (AIDS)-free time equivalent to that of men starting HAART with CD4(+) cell counts of <200 cells/microl. Within 3.5 years following HAART initiation, 11.3% of the subjects developed AIDS and 8.5% died. Determinants of AIDS were a CD4(+) cell count of <200 cells/microl at initiation (relative hazard = 2.25, 95% confidence interval: 1.13, 4.49) and age >45 years at initiation (relative hazard = 1.92, 95% confidence interval: 0.98, 3.77). An increase in CD4(+) cell count of >50 cells/microl immediately after HAART initiation also improved prognosis (relative hazard = 0.34, 95% confidence interval: 0.16, 0.71). AIDS risk in men starting HAART with CD4(+) counts of <200 cells/microl (median = 132) was similar to that of non-HAART users with CD4(+) counts of 375-475 cells/microl (median = 432). The equivalence of disease progression to that of nonusers with approximately 300 more cells per microl demonstrates that HAART users have a broader reconstitution of the immune system beyond that of observed increases in CD4(+) cell count.