Miracle-dz/UniFAR-FTUs huggingface dataset:
Rapid identification of female haemophilia A carriers with deletions in the factor VIII gene by quantitative Real-Time PCR analysis

Summary Large deletions of the factorVIII gene account for approximately 5% of severe haemophilia A patients. Although deletions are readily detectable in males, the identification of heterozygosity in possible carriers of these families still constitutes a challenge. In order to identify a deleted allele over the background of the normal allele in these carriers, we developed a rapid real-time quantitative PCR approach by means of LightCycler technology and SYBR green I for monitoring product formation. The method was applied to families with independent deletions (one in exon 14 and the other in exons 23-24) of the Factor VIII gene, thereby allowing a reliable determination of carrier or non-carrier status. The method is extremely versatile and can be adapted to other deletions within the factor VIII gene as well as to other diseases whose molecular pathology consists of deletions or duplications.
Reduced Expression of the let-7 MicroRNAs in Human Lung Cancers in Association with Shortened Postoperative Survival

In this study, we report for the first time reduced expression of the let-7 microRNA in human lung cancers. Interestingly, 143 lung cancer cases that had undergone potentially curative resection could be classified into two major groups according to let-7 expression in unsupervised hierarchical analysis, showing significantly shorter survival after potentially curative resection in cases with reduced let-7 expression (P = 0.0003). Multivariate COX regression analysis showed this prognostic impact to be independent of disease stage (hazard ratio = 2.17; P = 0.009). In addition, overexpression of let-7 in A549 lung adenocarcinoma cell line inhibited lung cancer cell growth in vitro. This study represents the first report of reduced expression of let-7 and the potential clinical and biological effects of such a microRNA alteration.
Generation of microwave oscillations in a current-driven magnetic nanocontact with ferroelectric and multiferroic junction

In this work the generation of the microwave oscillations by multilayered structure, which consists of two nanosized ferromagnetic layers La2/3Sr1/3MnO3 (LSMO) and Au separated by barrier multiferroic layer (2nm thickness) La0.1Bi0. 9MnO3 (LBMO) mediated by dc-current, is considered. The proposed approach is based on the macrospin approximation and spin-wave analysis of the magnetization. We find the main characteristics of the spintronic microwave oscillator - the output power and generation frequency. We discuss the recent demonstrations of giant resistive switching observed in ferroelectric tunnel junctions and its potential applications in microwave generation. Summary the main result, that we find in our work, that the output power of the multiferroic tunnel-junction spin-torque nanooscillator is near tens of milliwatts, which is quite enough for teleccomunication applications of these samples.
3D micro-CT analysis of void formations and push-out bonding strength of resin cements used for fiber post cementation

PURPOSE To investigate the void parameters within the resin cements used for fiber post cementation by micro-CT (µCT) and regional push-out bonding strength. MATERIALS AND METHODS Twenty-one, single and round shaped roots were enlarged with a low-speed drill following by endodontic treatment. The roots were divided into three groups (n=7) and fiber posts were cemented with Maxcem Elite, Multilink N and Superbond C&B resin cements. Specimens were scanned using µCT scanner at resolution of 13.7 µm. The number, area, and volume of voids between dentin and post were evaluated. A method of analysis based on the post segmentation was used, and coronal, middle and apical thirds considered separately. After the µCT analysis, roots were embedded in epoxy resin and sectioned into 2 mm thick slices (63 sections in total). Push-out testing was performed with universal testing device at 0.5 mm/min cross-head speed. Data were analyzed with Kruskal–Wallis and Mann–Whitney U tests (α=.05). RESULTS Overall, significant differences between the resin cements and the post level were observed in the void number, area, and volume (P<.05). Super-Bond C&B showed the most void formation (44.86 ± 22.71). Multilink N showed the least void surface (3.51 ± 2.24 mm2) and volume (0.01 ± 0.01 mm3). Regional push-out bond strength of the cements was not different (P>.05). CONCLUSION µCT proved to be a powerful non-destructive 3D analysis tool for visualizing the void parameters. Multilink N had the lowest void parameters. When efficiency of all cements was evaluated, direct relationship between the post region and push-out bonding strength was not observed.
The battle over the FCC Blue Book: determining the role of broadcast media in a democratic society, 1945-8

During the 1940s a media reform movement of grassroots activists and a progressive Federal Communication Commission (FCC) emerged to challenge the commercial interests consolidating control of US media. A key initiative born out of this movement was the so-called Blue Book, a high-water mark for FCC progressive activism that mandated social responsibility obligations for broadcasters in return for their use of the public airwaves. Ultimately, red-baiting tactics defeated the policy initiatives outlined in the Blue Book and the media reform movement was largely contained. The following analysis draws from archival materials to illuminate the resulting arrangement for US broadcasters.
Achievement Goal Orientations and Intrinsic Motivation in a Track and Field Event in School Physical Education

To date, substantial evidence exists that supports the health benefits associated with regular physical activity (Bouchard, Shephard & Stephens, 1994). Furthermore, school physical education has been recognised as being in a position to prepare children to make physical exercise a part of their way of life (Sallis & McKenzie, 1991). As Fox and giddle (1988), drawing from evidence accumulated from adults, suggest, an effective way of ’promoting long-term activity rests with the fostering and maintenance of intrinsic interest’ (p. 81). They go on to suggest that the two most important intrinsic elements for children
On the efficiency of the walrasian mechanism

Central results in economics guarantee the existence of efficient equilibria for various classes of markets. An underlying assumption in early work is that agents are price-takers, i.e., agents honestly report their true demand in response to prices. A line of research in economics, initiated by Hurwicz (1972), is devoted to understanding how such markets perform when agents are strategic about their demands. This is captured by the Walrasian Mechanism that proceeds by collecting reported demands, finding clearing prices in the reported market via an ascending price tatonnement procedure, and returns the resulting allocation. Similar mechanisms are used, for example, in the daily opening of the New York Stock Exchange and the call market for copper and gold in London. In practice, it is commonly observed that agents in such markets reduce their demand leading to behaviors resembling bargaining and to inefficient outcomes. We ask how inefficient the equilibria can be. Our main result is that the welfare of every pure Nash equilibrium of the Walrasian mechanism is at least one quarter of the optimal welfare, when players have gross substitute valuations and do not overbid. Previous analysis of the Walrasian mechanism have resorted to large market assumptions to show convergence to efficiency in the limit. Our result shows that approximate efficiency is guaranteed regardless of the size of the market. We extend our results in several directions. First, our results extend to Bayes-Nash equilibria and outcomes of no regret learning via the smooth mechanism framework. We also extend our bounds to any mechanism that maximizes welfare with respect to the declared valuations and never charges agents more than their bids. Additionally, we consider other classes of valuations and bid spaces beyond those satisfying the gross substitutes conditions. Finally, we relax the no-overbidding assumption, and present bounds that are parameterized by the extent to which agents are willing to overbid.
Are Australian fans of anime and manga motivated to learn Japanese language?

Recent research into Japanese as a foreign language education has strongly emphasized the link between Japanese popular culture and learning Japanese. However, these studies have only targeted Japanese language learners in formal education contexts and have largely ignored those who are not studying Japanese or studying Japanese informally. This present study claims that it is premature to link the two in this way. Using the notions of public pedagogy, the continuum of informal–formal learning, and out-of-school curriculum as our theoretical underpinnings, we examine how a cohort of fans deals with learning Japanese and about Japan in relation to their consumption of Japanese manga and anime. The results of an online survey of 451 Australia based manga and anime fans reveal that their interest in and motivation to consume these media may not necessarily lead them to enter into formal Japanese language education.
Subcision‐suction method: a new successful combination therapy in treatment of atrophic acne scars and other depressed scars

Background Among therapeutic modalities of acne scars, subcision is a simple, safe procedure with a different and basic mechanism for correcting atrophic and depressed scars. Subcision releases scar surfaces from underlying attachments and induces connective tissue formation beneath the scar directly, without injury to the skin surface. Therefore, subcision is a valuable method, but due to high recurrence rate, its efficacy is mild to moderate.
Vision and Relations: Elements for an Entrepreneurial Metamodel

Dr LOUIS JACQUES FILION WAS UNTIL recently director of the Master's programme in Small Business at the University of Quebec at Trois Rivieres. He has recently been appointed director of training and research at the Heart of Quebec Enterpreneurship Center attached to the same university. This research is based on a smaple of 59 enterpreneurs-51 in small firms and eight in large firms from five countries. The implict systemic model of each enterpreneur was mapped using the soft systems methodology developed by Peter Checkland at the University of Lancaster in Britain. Data was gathered through in-depth interviews with the enterpreneurs themselves and,in most cases, teh people around them. The metamodel presetned tin this paper is a result of superimposing the models derived from each enterpreneur studied. This model implies three categories of vision: emerging, central and secondary. Following presentation and explanation of each category, a visionary process is proposed, based on the study and analysis of what enterpreneur do. The main factor supporting both teh development of teh vision and visionary achievement seems to be the enterpreneur's relations systems. Although it is the man factor as far the development of the vision is concrened, theree otehr factors also contribute to the visionary process: leadership, energy and the perceptive system conditioned by each individual's own values. this latter is introduced as the concept of Weltancschauung. A visionary process presetns an interest for enterpreneurial activites as it offers as framework for reflection and actions. It also offers a way for the enterpreneurs to integrate a tam into what he is doing.
Dermatomyositis complicated with hemorrhagic shock of the iliopsoas muscle on both sides and the thigh muscle

A 65-year-old Japanese woman, diagnosed with dermatomyositis with myopathy and characteristic skin lesion, was intravenously administered methylprednisolone 500 mg per day for 3 days, followed by prednisolone 60 mg po per day. Four days later, she went into shock. Computed tomography of the abdomen showed hematoma in the iliopsoas muscle on both sides and a thigh muscle. Intravenously administered heparin was stopped, and 4 U of packed cells and 4 U of fresh frozen plasma were transfused. The patient subsequently developed pulmonary edema requiring assisted ventilation, and made a successful recovery, returning home after a short period of intensive rehabilitation.
Hearing threshold levels for an otologically screened population in Spain

Abstract Objective: The aim of the present study was to provide thresholds data as a function of age for an otologically normal population in Spain, compared to the current ISO 7029 (2000) standard. Design: A prospective study in an otologically screened population. Study sample: Data was collected from 1175 otologically-normal persons aged between 5 and 90 years. Inclusion criteria involved those listed in ISO 389-1 (1998) and the 8253-1 (2010). Suitability for inclusion was evaluated through interview, based on a questionnaire, and physical examination. Results: The hearing thresholds decreased slightly from 125 to 2000 Hz. From 2000 Hz onwards the thresholds increased; this increase being more pronounced with increasing frequency and age. No statistically significant sex differences were found. The hearing threshold levels in the present study were higher (poorer) than the ones provided by ISO 7029 (2000). Conclusions: Results from this study suggest that the thresholds listed in ISO 7029 (2000) may be too restrictive, and could be useful in formulating the ISO 7029 update.
Vision Assisted Autonomous Landing of an Unmanned Aerial Vehicle.

In this paper, a strategy for an autonomous landing maneuver for an underactuated, unmanned aerial vehicle (UAV) using position information obtained from a single monocular on-board camera is presented. Although the UAV is underactuated in translational control inputs (i.e., a lift force can only be produced), the proposed controller is shown to achieve globally uniform ultimate boundedness (GUUB) in position regulation error during the landing approach. The proposed vision-based control algorithm is built upon homography-based techniques and Lyapunov design methods.
Passive immunization in experimental Herpesvirus hominis infection of newborn mice

Infection of newborn mice with Herpesvirus hominis type 2(HVH-2) was used as an experimental model of disseminated HVH infection in newborn humans. Mice were challenged with 103 plaque-forming units of HVH-2 intranasally and were given 0.2 ml of rabbit serum intraperitoneally. Passive immunizations with rabbit anti-HVH-2 serum resulted in a significant decrease in mortality and prolongation of survival time. This effect correlated with the neutralizing antibody titer of the serum against HVH-2 and was more pronounced when immune serum was administered 1 h after infection as compared with 24 h. These results suggest that administration of high-titer anti-HVH-2 immunoglobulins shortly after delivery could afford significant protection to the newborn of a mother with genital HVH-2 infection.
Analysis of Myosin Heavy Chain Isoforms from Longissimus Thoracis Muscle of Hanwoo Steer by Electrophoresis and LC-MS/MS

The purpose of this study was to analyze myosin heavy chain (MHC) isoforms in bovine longissimus thoracis (LT) muscle by liquid chromatography (LC) and mass spectrometry (MS). LT muscles taken from Hanwoo (Korean native cattle) steer (n=3) used to separate myosin bands by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The peptide queries were obtained from the myosin bands by LC-MS/MS analysis following in-gel digestion with trypsin. A total of 33 and 43 queries were identified as common and unique peptides, respectively, of MHC isoforms (individual ions scores >43 indicate identity or extensive homology, p<0.05). MHC-1 (IIx), -2 (IIa), -4 (IIb), and -7 (slow/I) were identified based on the Mowse score (5118, 3951, 2526, and 2541 for MHC-1, -2, -4, and -7, respectively). However, more analysis is needed to confirm the expression of MHC-4 in bovine LT muscle because any query identified as a unique peptide of MHC-4 was not found. The queries that were identified as unique peptides could be used as peptide markers to confirm MHC-1 (14 queries), -2 (8 queries), and -7 (21 queries) in bovine LT muscle; no query identified as a unique peptide of MHC-4 was found. LC-MS/MS analysis is a useful approach to study MHC isoforms at the protein level.
Effects of Specificity on the Interpretation of Anaphoric Noun Phrases

Reading-time experiments on anaphor resolution have produced conflicting results. Some studies have been taken to support a schema-based theory of text comprehension, which claims that the ease of interpreting an anaphor depends on the schemata that are currently activated. Other studies suggest that more specific factors, such as the amount of new information carried by an anaphor, affect the amount of time needed to understand it. This paper reports an experiment designed to confirm the importance of an anaphor's information content in determining how much processing it requires. The experiment also investigates the role of schemata in anaphor resolution. It provides no evidence for schema-based processing. However, it is difficult to decide whether the materials used in the experiment should produce schematic effects. It is argued that this is a fault of schema theory, and unless this fault is rectified the theory cannot be regarded as a serious contender for an account of anaphor resolution.
Clioquinol for the treatment of Alzheimer's Disease.

BACKGROUND Alzheimer's disease (AD) may result in senile plaques being formed outside the brain as accumulation of beta-amyloid (Ass). OBJECTIVES To evaluate the efficacy of clioquinol for the treatment of cognitive impairment due to Alzheimer's disease. SEARCH STRATEGY The Cochrane Dementia and Cognitive Improvement Group's Specialized Register was searched on 20 May 2005 using the terms clioquinol and PBT1. The Register contains records from major health care databases and many ongoing trial databases and is updated regularly. The Internet was searched using the term: clioquinol PBT1 Alzheimer*. SELECTION CRITERIA Randomised double-blind trials in which treatment with clioquinol was administered to participants with Alzheimer's disease in parallel group comparison with placebo are included. DATA COLLECTION AND ANALYSIS Two reviewers (RM, LJ) independently assessed the quality of trials according to the Cochrane Collaboration Handbook. The primary outcome measures of interest were cognitive function (as measured by psychometric tests) and global impression. The secondary outcome measures of interest were in the following areas: quality of life, functional performance, effect on carer, safety and adverse effects, and death. MAIN RESULTS There was one included trial of clioquinol compared with placebo in 36 patients. AUTHORS' CONCLUSIONS It is not clear from the trial that clioquinol shows any positive clinical result on patients with AD. The two statistically significant positive results were seen for the more severely affected subgroup of patients. This effect was not maintained at the 36 week end-point. The sample size was small. Details of randomisation procedure or blinding were not reported. Further studies are needed to evaluate the potential for clioquinol as a treatment of AD. Trials of longer duration are also required, particularly because information about the side-effects of long-term use of clioquinol is limited.
Gender as a Personal and Cultural Construction

_I -W R I T E T H I S A R T I C L E motivated by my concern (with Mahoney and Yngvesson 1992) that recent academic feminist theory seems to have moved away from psychology. I believe that two directions in contemporary feminist thought underlie this move. My article tries to accommodate one of these directions; it takes issue with the other. For despite the recent disenchantment with psychology, the ongoing development of psychoanalytic feminism as an academic enterprise suggests that some feminists continue to think that the psychology of gender is important. We turned to the psychology of gender in the first place because it seemed directly, experientially important to our lives as women and because we thought that there was something in psychology that helped account for the tenacity of gender relations. First, contemporary feminism has been rightfully wary of universalizing claims about gender and of accounts that seem to reduce gender to a single defining or characterizing feature. Psychological claims of all sorts have been a special focus of this criticism. Psychoanalytic feminism, feminist psychologies, and feminist psychoanalysis and therapy (the last of these not so much noticed by academic feminists) have not paid sufficient attention to differences and variation among women and to the variety, instability, multiplicity, and contested nature of gender meanings. Psychoanalytic feminism and other feminist psychologies also often claim a single factor or aspect of psychology as most important in defining women or femininity. I offer in this article a more clinically and less theoretically or developmentally based way of thinking about psychological gender in order to respond to these feminist criticisms of psychology and psychoanalysis while at the same time retaining insights from psychology that feminism has found useful. Such an approach also pro
Reconfigurable FIR filter using distributed arithmetic on FPGAs

An architecture for a dynamically run-time reconfigurable finite impulse response (FIR) filter is presented in this work. It is based on distributed arithmetic (DA) combined with a look-up table (LUT) reduction technique which allows the direct mapping to reconfigurable LUTs (CFGLUT) of the latest Xilinx FPGAs. The resulting FIR filter can be reconfigured with arbitrary coefficients which are only limited by their length and word size. The number of filter instances for reconfiguration is only limited by the block memory of the FPGA which typically allows hundreds of different configurations. The proposed reconfigurable architecture consumes 16% less slices on average than a fixed coefficient DA filter generated by Xilinx Coregen. As the direct mapping to CFGLUTs leads to invalid filter output during reconfiguration, an alternative architecture is proposed which avoids this limitation at the cost of 19% more slice resources on average. Using a parallel reconfiguration scheme, reconfiguration times of about 100ns could be achieved.
Ubuntu and the recent phenomenon of the Charter for Compassion

ABSTRACTArguably for the first time in human history there is now the emergence of an inclusive existential ethical sensibility that claims to transcend religious and cultural categorizations and is accessible to, and potentially resonates with, a diverse and multifarious mainstream majority. Compassion stands at the centre of this project as a collective commonality and a cohesive driver of contemporary imagination and discourse. The recent global Charter for Compassion is a signpost and codification of this new movement. But how does it correspond with the challenges of an African context, where the concept of ubuntu has a long history? South Africa is indeed a microcosm of the rest of the world and our engagement with the questions of a modern-day moral vacuum and religion is important for its significance on a global scale. This article aims to engage with contemporary discourses around ubuntu and the Charter for Compassion in order to investigate possible correspondences between these two humanitaria.