Miracle-dz/UniFAR-FTUs huggingface dataset:
Recollection and familiarity in amnesic mild cognitive impairment.

OBJECTIVE To investigate whether, in patients with amnesic mild cognitive impairment (a-MCI), recognition deficits are mainly due to a selective impairment of recollection rather than familiarity. METHODS Nineteen patients with a-MCI and 23 sex-, age-, and education-matched healthy controls underwent two experimental investigations, using the Process Dissociation Procedure (PDP) and the Remember/Know (R/K) procedure, to assess the differential contribution of recollection and familiarity to their recognition performance. RESULTS Both experimental procedures revealed a selective preservation of familiarity in a-MCI patients. Moreover, the R/K procedure showed a statistically significant impairment of recollection in a-MCI patients for words that were either read or anagrammed during the study phase. CONCLUSIONS A-MCI is known to be commonly associated with a high risk of conversion to Alzheimer's disease (AD). Several previous studies have demonstrated a characteristic impairment of episodic memory in a-MCI, with an early dysfunction of recognition. Our findings are consistent with the knowledge of neurodegeneration occurring in AD, which is characterized, at the earliest disease stages, by a selective involvement of the entorhinal cortex. Moreover, the current study supports the dual process model of recognition, which hypothesizes recollection and familiarity to be independent processes associated with distinct anatomical substrates.
Efficient Pattern Recognition Using a New Transformation Distance

Memory-based classification algorithms such as radial basis functions or K-nearest neighbors typically rely on simple distances (Euclidean, dot product.), which are not particularly meaningful on pattern vectors. More complex, better suited distance measures are often expensive and rather ad-hoc (elastic matching, deformable templates). We propose a new distance measure which (a) can be made locally invariant to any set of transformations of the input and (b) can be computed efficiently. We tested the method on large handwritten character databases provided by the Post Office and the NIST. Using invariances with respect to translation, rotation, scaling, shearing and line thickness, the method consistently outperformed all other systems tested on the same databases.
Sentinel lymph node detection with Tc-99m tin colloids in patients with esophagogastric cancer.

BACKGROUND The aim of this study was to determine by radioisotope use whether the sentinel lymph node concept is applicable to esophagogastric cancers. In addition, we examined radioactivities of hot nodes and compared them with the sensitivity of a gamma probe. METHODS The subjects were 44 patients, 23 with esophageal cancer and 21 with gastric cancer. The day before surgery, patients underwent endoscopic submucosal injection of 184 MBq of Tc-99m tin colloids into sites surrounding the tumor. Radioisotope activities of lymph nodes dissected at surgery were measured with a well-typed gamma detector and each lymph node was categorized as a hot or cold node. Histopathology of the lymph nodes was examined by hematoxylin and eosin staining. Radioisotope activities and histopathological results were compared to determine whether radioisotope flow reflects lymphatic flow to regional lymph nodes. The sensitivity of a gamma probe was measured in a laboratory study and the relation between the radioisotope activities of hot nodes and the detection sensitivity of the gamma probe was examined. RESULTS Histopathological examination revealed lymph node metastasis in 18 of the 44 patients. In 15 of these 18 patients, metastatic foci were recognized in at least one hot node. Subsequent analysis was performed on the 36 patients in whom tumor invasion was confined to the muscle layer and in whom endoscopic clippings had not been applied. Lymph node metastases were observed in 12 of these 36 patients. In these 12 patients, at least one hot node was positive for metastasis. The laboratory study revealed that the gamma probe was able to detect radioisotope activities of >/=0.02 micro Ci. Thirty-two of 63 (51%) esophageal cancer hot nodes and 16 of 86 (19%) gastric cancer hot nodes showed radioisotope activities below the detection sensitivity of the gamma probe. CONCLUSION The sentinel lymph node concept is applicable to patients with esophageal and gastric cancers; however, further studies are necessary to identify hot nodes accurately using gamma probes.
Perceived neighborhood violence and use of verbal aggression, corporal punishment, and physical abuse by a national sample of parents in Israel

This study, based on an ecological perspective, examined the relation of perceived neighborhood violence, child misbehavior, parental attitudes to aggressive discipline tactics, and the actual use of aggressive discipline tactics. Research questions were: To what extent is perceived neighborhood violence associated with aggressive discipline by parents? What is the mechanism through which perceived neighborhood violence is linked to aggressive discipline? Data were obtained from a stratified probability sample of 1,649 women. Findings indicated that the more the study participants perceived their neighborhood as violent, the more frequent is the parental use of aggressive discipline. It seems that child misbehavior and parental approval of corporal punishment are affected by perceived neighborhood violence and, in turn, affect parental use of aggressive disciplines. Furthermore, the relationships of child misbehavior, parental approval of aggressive discipline, and the use of aggressive discipline are different in low and high levels of perceived neighborhood violence. © 2011 Wiley Periodicals, Inc.
Prevalence of undertreatment in cancer pain. A review of published literature.

BACKGROUND Pain is a major health care problem for patients with cancer: despite the existence of guidelines for cancer pain management, undertreatment is a widespread problem. Pain Management Indexes (PMIs) evaluate the congruence between the patient's reported level of pain and the intensity/strength of the analgesic therapy. Negative scores indicate inadequate prescriptions. MATERIALS AND METHODS We conducted a Medline search using terms for 'pain management', 'index' or 'measure' to select studies which measured undertreatment in cancer settings. Univariate and multivariate logistic regression identified associations between independent predictors and high prevalence of undertreatment. RESULTS Among the 44 studies identified, 26 studies used the PMI as proposed by Cleeland. The range of negative PMI varied from 8% to 82% with a weighted mean value of 43%. In multivariate analyses, factors associated with negative PMI were date of publication before 2001, provenance from Europe or Asia and countries with a gross national income per capita < $40,000 per year and a care setting not specific for cancer. Age was not a significant predictor for undertreatment. CONCLUSION Nearly one of two patients with cancer pain is undertreated. The percentage is high, but consists of a large variability of undertreatment across studies and settings.
Proteomic identification of nitrated proteins in Alzheimer's disease brain

Nitration of tyrosine in biological conditions represents a pathological event that is associated with several neurodegenerative diseases, such as amyotrophic lateral sclerosis, Parkinson's disease and Alzheimer's disease (AD). Increased levels of nitrated proteins have been reported in AD brain and CSF, demonstrating the potential involvement of reactive nitrogen species (RNS) in neurodegeneration associated with this disease. Reaction of NO with leads to formation of peroxynitrite ONOO–, which following protonation, generates cytotoxic species that oxidize and nitrate proteins. Several findings suggest an important role of protein nitration in modulating the activity of key enzymes in neurodegenerative disorders, although extensive studies on specific targets of protein nitration in disease are still missing.
Political Polarization as a Social Movement Outcome

Radical social movements can exacerbate tensions in local settings while drawing attention to how movement goals align with political party agendas. Short-term movement influence on voting outcomes can endure when orientations toward the movement disrupt social ties, embedding individuals within new discussion networks that reinforce new partisan loyalties. To demonstrate this dynamic, we employ longitudinal data to show that increases in Republican voting, across several different time intervals, were most pronounced in southern counties where the Ku Klux Klan had been active in the 1960s. In an individual-level analysis of voting intent, we show that decades after the Klan declined, racial attitudes map onto party voting among southern voters, but only in counties where the Klan had been active.
Exploring Individual Brain Variability during Development based on Patterns of Maturational Coupling of Cortical Thickness: A Longitudinal MRI Study

Structural covariance has recently emerged as a tool to study brain connectivity in health and disease. The main assumption behind the phenomenon of structural covariance is that changes in brain structure during development occur in a coordinated fashion. However, no study has yet explored the correlation of structural brain changes within individuals across development. Here, we used longitudinal magnetic resonance imaging scans from 141 normally developing children and adolescents (scanned 3 times) to introduce a novel subject-based maturational coupling approach. For each subject, maturational coupling was defined as similarity in the trajectory of cortical thickness (across the time points) between any two cortical regions. Our approach largely captured features seen in population-based structural covariance, and confirmed strong maturational coupling between homologous and near-neighbor cortical regions. Stronger maturational coupling among several homologous regions was observed for females compared to males, possibly indicating greater interhemispheric connectivity in females. Developmental changes in maturational coupling within the default-mode network (DMN) aligned with developmental changes in structural and functional DMN connectivity. Our findings indicate that patterns of maturational coupling within individuals may provide mechanistic explanation for the phenomenon of structural covariance, and allow investigation of individual brain variability with respect to cognition and disease vulnerability.
Calpains Contribute to Vascular Repair in Rapidly Progressive Form of Glomerulonephritis: Potential Role of Their Externalization

Objective—Calpains, calcium-activated proteases, mediate the angiogenic signals of vascular endothelial growth factor. However, their involvement in vascular repair has not been investigated and the underlying mechanisms remain to be fully elucidated. Methods and Results—A rapidly progressive form of glomerulonephritis in wild type and transgenic mice expressing high levels of calpastatin, a calpain-specific inhibitor, was studied. Calpastatin transgene expression prevented the repair of peritubular capillaries and the recovery of renal function, limiting mouse survival. In vitro analysis detected a significant reduction of both intracellular and extracellular calpain activities in transgene expressing cells, whereas Western blotting revealed that proangiogenic factors vascular endothelial growth factor and norepinephrine increased calpain exteriorization. In vitro, extracellular calpains increased endothelial cell proliferation, migration and capillary tube formation. In vivo, delivery of nonpermeable extracellular calpastatin was sufficient to blunt angiogenesis and vascular repair. Endothelial cell response to extracellular calpains was associated with fibronectin cleavage, generating fibronectin fragments with proangiogenic capacity. In vivo, fibronectin cleavage was limited in the kidney of calpastatin transgenic mice with nephritis. Conclusion—This study demonstrates that externalized calpains participate in angiogenesis and vascular repair, partly by promoting fibronectin cleavage and thereby amplifying vascular endothelial growth factor efficiency. Thus, manipulation of calpain externalization may have therapeutic implications to control angiogenesis.
Financial support systems: the student experience in England and France

Purpose – To investigate how the financial status of students in England and France affects their experience of university life. Design/methodology/approach – A questionnaire survey was carried out among undergraduates in two countries. There were 168 responses from students studying at a French university and 325 responses from students studying at an English university. Findings – The financial burden in France rests with parents, while in England students are largely responsible for their own funding. Indicators suggest that English students may be suffering from financial difficulties.Students continue the tradition of enjoying themselves and socialising, whatever their nationality and financial status. Research limitations/implications – The comparison made was not between institutions of equal status. The Institut de Formation Internationale in Rouen is part of a Grande Ecole group which is private, and may attract students from higher income families. The students at Manchester Metropolitan University Cheshire study in a rural locale (the towns of Crewe and Alsager in south Cheshire), which is unusual for a UK university and it may well be that a lower proportion of these undergraduates come from higher income families than the French students. Practical implications – While it would seem to be more equitable and economically efficient for individuals to pay directly for services they receive, rather than those services being funded by higher tax, this study highlights certain problems. The quality of the educational experience for English students may be reduced by their continuing to live at home with parents and carrying out low level work while studying. Originality/value – No other research appears to have been carried out in the UK or in France on this topic.
Effects of insulin-like growth factor on nitrogen balance during hypoxic exposure

Acute exacerbations of chronic obstructive pulmonary disease (COPD) accompanied with hypoxaemia may induce net protein catabolism and hypoxaemia could be an important trigger of a systemic catabolic response. The aim of this study was to examine the anabolic effects of recombinant human insulin-like growth factor‐I (IGF‐I) in rats exposed to hypoxia. Although acute hypoxia is usually accompanied with a decrease in dietary intake, the usual nitrogen intake was maintained in this study. Sprague-Dawley rats were maintained by continuous infusion of solution for total parenteral nutrition for 6 days. The animals were then randomly assigned to a normoxic (N) or a hypoxic (H) group. During the last 3 days of the experiment N and H rats were randomised to receive either IGF‐I or vehicle. Exposure to hypoxia caused a decrease in body-weight gain accompanied by a negative nitrogen balance, which was mainly due to increased urinary nitrogen excretion. No effect of recombinant human IGF‐I treatment on body weight was observed during exposure to hypoxia, although nitrogen balance normalised. The co-infusion of recombinant human insulin-like growth factor‐1 and total parenteral nutrition has a significant net anabolic effect, as demonstrated by nitrogen retention and reduction in urine protein excretion observed in rats. Insulin-like growth factor‐1 may help to ameliorate the protein catabolism observed under hypoxic conditions.
Recidivism Among a White-Collar Sample: Does Personality Matter?

Abstract With the exception of correctional research, the role of personality has been understudied in criminology in general and in the study of white-collar crime in particular. The usefulness of personality has typically been restricted to use as a diagnostic tool in differentiating among offenders for correctional classification purposes. The current research focuses on a sample of white-collar offenders who were convicted in federal courts to explain what role personality plays in explaining their rates of recidivism. Using the Jesness Inventory as a measure of personality, findings reveal that personality type is a significant predictor of offender recidivism with neurotic personality type significantly predicting probability of rearrest.
Legal Responses to Trafficking in Narcotics and Other Narcotic Offenses in China

Narcotics offenses have been surging since the economic reforms in China. As a response, laws and governmental decrees have been promulgated and revised to curb these emerging and changing crimes. This article focuses on these evolving laws and policies pertinent to narcotics offenses in China. Using criminal court judgment documents of 362 cases tried after 1978, the authors further analyze the sentencing patterns of these narcotics offenses and examine whether and to what extent sentencing decisions were affected by legal and extralegal factors. The authors conclude with discussions of some theoretical and practical implications based on this research.
Comparison of continuous arterial pressure waveform analysis with the lithium dilution technique to monitor cardiac output in conscious dogs with systemic inflammatory response syndrome.

OBJECTIVE To assess the agreement between cardiac output (CO) measured by use of arterial pressure waveform analysis (PulseCO) and lithium dilution (LiDCO) in conscious dogs with systemic inflammatory response syndrome (SIRS). ANIMALS 14 dogs with naturally occurring SIRS. PROCEDURES Pulse power analysis was performed on critically ill patients with a PulseCO monitor. All measurements were obtained with an indwelling arterial line and in accordance with the manufacturer's instructions. Intermittent measurements of CO were obtained with the LiDCO method to validate the PulseCO measurements at initial calibration (baseline; time 0) and at 4, 8, 16, and 24 hours. The 2 methods for measuring CO were compared by use of Bland-Altman analysis. An error rate for the limits of agreement between the 2 methods of < 30% was defined as being acceptable. RESULTS Bland-Altman analysis did not indicate good agreement between measurements obtained by use of the PulseCO and LiDCO methods, despite no significant change in cardiac index (CI) over time as measured with the LiDCO method. The percentage error for the overall difference in CI values between the PulseCO and LiDCO measurements was 122%, which indicated that the PulseCO method was not an acceptable means of CO measurement when compared with the LiDCO method for this patient population. CONCLUSIONS AND CLINICAL RELEVANCE Agreement between the PulseCO and LiDCO methods for measurement of CO was not acceptable at 4- and 8-hour intervals after calibration in conscious dogs with naturally occurring SIRS.
Juxtapositioning Geriatrics and Art: The Essence of Caring, Carer, and Cared-for in Films

The need to revolutionize geriatric nursing is dawning. However, there is a negative view regarding this nursing field. The dearth of literature on the use of theatrical films to surface universal realities in a care-driven profession has led to this attempt of bringing to reality the essences of caring, carer, and cared-for and their interactions with each other. This paper presents an innovation of selecting a film (Away From Her) to surface the essences, or lebenswelt, of three universal realities: caring, carer, and cared-for. Content analysis and appreciative inquiry were utilized to achieve the objectives of this study. This bold attempt to tap the field of art, particularly films, has led to the genesis of three themes that resulted from the interaction of the objects under study. The C3 (Carer-Caring-Cared-for) Interaction Model crystallizes the nexus between and among living, learning, and loving in geriatric practice.
Application of Fuzzy Logic Approach for an Aircraft Model with and without Winglet

—The measurement of aerodynamic forces and moments acting on an aircraft model is important for the development of wind tunnel measurement technology to predict the performance of the full scale vehicle. The potentials of an aircraft model with and without winglet and aerodynamic characteristics with NACA wing No. 65-3- 218 have been studied using subsonic wind tunnel of 1 m × 1 m rectangular test section and 2.5 m long of Aerodynamics Laboratory Faculty of Engineering (University Putra Malaysia). Focusing on analyzing the aerodynamic characteristics of the aircraft model, two main issues are studied in this paper. First, a six component wind tunnel external balance is used for measuring lift, drag and pitching moment. Secondly, Tests are conducted on the aircraft model with and without winglet of two configurations at Reynolds numbers 1.7×10 5 , 2.1×10 5 , and 2.5×10 5 for different angle of attacks. Fuzzy logic approach is found as efficient for the representation, manipulation and utilization of aerodynamic characteristics. Therefore, the primary purpose of this work was to investigate the relationship between lift and drag coefficients, with free-stream velocities and angle of attacks, and to illustrate how fuzzy logic might play an important role in study of lift aerodynamic characteristics of an aircraft model with the addition of certain winglet configurations. Results of the developed fuzzy logic were compared with the experimental results. For lift coefficient analysis, the mean of actual and predicted values were 0.62 and 0.60 respectively. The coreelation between actual and predicted values (from FLS model) of lift coefficient in different angle of attack was found as 0.99. The mean relative error of actual and predicted valus was found as 5.18% for the velocity of 26.36 m/s which was found to be less than the acceptable limits (10%). The goodness of fit of prediction value was 0.95 which was close to 1.0.
Dealing with Urban Terror: Heritages of Control, Varieties of Intervention, Strategies of Research*

The events of September 11th bring urgency to problems of urban security, both in terms of finding ways to protect cities from attacks by terrorists and also protecting urban life from repressive measures that form in reaction to those attacks. We outline a rationale for urbanists to participate in analysis and policy‐formulation on security issues and examine the utility of past urban research strategies, including criminology, in terms of their relevance to the current challenge. We suggest principles to guide future urban policy in light of past experiences. Les evenements du 11 septembre rendent urgents les problemes de securite urbaine, a la fois pour trouver des facons de proteger les villes contre des attaques terroristes et pour preserver la vie urbaine de mesures repressives en reponse a ces attaques. L'article argumente en faveur de la participation d'urbanistes a l'analyse et a la formulation d'une politique publique sur les questions de securite. Il examine le parti a tirer des strategies de recherches urbaines anterieures (y compris en criminologie) en fonction de leur pertinence par rapport au defi actuel. De plus, il suggere des principes permettant d'orienter la politique urbaine future a la lumiere des experiences passees.