Miracle-dz/UniFAR-FTUs huggingface dataset:
Teachers' and students' conceptions of the professional world

In the original 'Improving Student Learning' project led by Prof Graham Gibbs in 1991, one of the case studies focused on approaches to learning on a BA(Hons) Graphic Information Design course. The case study, led by Allan Davies, had the modest intention of trying to determine whether a particular curriculum innovation encouraged a deep approach to learning. Our only significant tool then was Bigg's SOLO taxonomy. Eleven years later and the innovators have moved on, the course has disappeared and the research context and methodologies have developed. During this period, research has suggested that both teachers and students describe their understanding of teaching and learning according to their perception of the teaching/ learning environment (Ramsden, 1992; Prosser & Trigwell, 1999). Studies have identified variation in the way that teachers experience teaching (Samuelowicz & Bain, 1992; Prosser, Trigwell & Taylor, 1994 for example) and variation in the way teachers experience student learning (Bruce & Gerber, 1995). More recently, Reid (1997) has widened the context of research by examining the relation between the experience of work and teaching/learning within the music discipline. In further research (Reid 1999), relations were found within the music discipline where teachers' and students' experience of one of three defined dimensions was strongly related to the ways in which they understood teaching and learning music. The musicians (and their students) described their experience of the professional world in three hierarchically related ways. This constitution has become known as the 'Music' Entity. In 1999, following a fortuitous meeting at the ISL conference in York, Davies and Reid conducted a joint enquiry, using a phenomenographic approach, to determine the 'Design' entity (Davies and Reid, 2001). This research focused on discerning the critical differences, or variation, in the way teachers and students experience and understand their subject and its relation to the professional design world. The outcomes of this research has, consequently, begun to impact on student learning through course design and, in particular, assessment. This paper will be a comparative study of the research already carried out by the authors in a number of disciplines in which the same focus and methodology has been used.
Ventricular distensibility and pressure-volume curve during sympathetic stimulation.

Experiments with an isovolumically contracting canine left ventricle preparation do not indicate that sympathetic cardiac nerve stimulation induces any alteration in ventricular distensibility. If the heart rate is sufficiently high to produce incomplete ventricular relaxation, sympathetic stimulation, by shortening systole, restores the relaxed pressure-volume relation without any indication, however, that ventricular distensibility is changed.
Intravenous glutamate enhances edema formation after a freezing lesion.

The effect of intravenous infusion of glutamate on edema formation after a freezing lesion in rats is reported. Twenty-four hours of continuous intravenous glutamate application led to a significant increase of hemispheric swelling, and of the water and sodium content as compared with animals receiving infusions of physiological saline after trauma. The results suggest that glutamate entering the e.c. space together with the edema fluid causes additional cytotoxic edema as a consequence of an enhanced glutamate uptake by the glia. Therefore, the use of amino acid infusions containing glutamate for parenteral nutrition may present an additional risk for neurosurgical patients with a disturbed BBB.
Unifying self-stabilization and fault-tolerance

In this paper we combine two previously disparate aspects of reliable distributed computing – selfstabllization, i.e., tolerance of systemic failures, and fault-tolerance, i.e., tolerance of process failures. We define what it means for a protocol to solve a problem while tolerating both types of failures and demonstrate a “compiler” that transforms a process failuretolerant protocol for a synchronous system into a process and systemic failure-tolerant protocol. For asynchronous systems, we present a protocol that solves a crucial problem (Consensus) while tolerating both process and systemic failures.
The Six-Point Dial of Treatment

The 6-point dial of treatment described in this case report is developed to guide graduate student psychological trainees through treatment and includes the following components: assessment of dangerousness, diagnosis, diagnosis-based treatment, ongoing evaluation of treatment response, obstacles to treatment, and motivation. The article describes the dial of treatment and present a case study of a client with paranoid schizophrenia (John) who presented at a graduate student training clinic to illustrate how this framework can be successfully applied. John exhibits marked improvement, based on both objective measures and clinician judgment of global functioning.
Homocysteine-Lowering by B Vitamins Slows the Rate of Accelerated Brain Atrophy in Mild Cognitive Impairment: A Randomized Controlled Trial

Background An increased rate of brain atrophy is often observed in older subjects, in particular those who suffer from cognitive decline. Homocysteine is a risk factor for brain atrophy, cognitive impairment and dementia. Plasma concentrations of homocysteine can be lowered by dietary administration of B vitamins. Objective To determine whether supplementation with B vitamins that lower levels of plasma total homocysteine can slow the rate of brain atrophy in subjects with mild cognitive impairment in a randomised controlled trial (VITACOG, ISRCTN 94410159). Methods and Findings Single-center, randomized, double-blind controlled trial of high-dose folic acid, vitamins B6 and B12 in 271 individuals (of 646 screened) over 70 y old with mild cognitive impairment. A subset (187) volunteered to have cranial MRI scans at the start and finish of the study. Participants were randomly assigned to two groups of equal size, one treated with folic acid (0.8 mg/d), vitamin B12 (0.5 mg/d) and vitamin B6 (20 mg/d), the other with placebo; treatment was for 24 months. The main outcome measure was the change in the rate of atrophy of the whole brain assessed by serial volumetric MRI scans. Results A total of 168 participants (85 in active treatment group; 83 receiving placebo) completed the MRI section of the trial. The mean rate of brain atrophy per year was 0.76% [95% CI, 0.63–0.90] in the active treatment group and 1.08% [0.94–1.22] in the placebo group (P = 0.001). The treatment response was related to baseline homocysteine levels: the rate of atrophy in participants with homocysteine >13 µmol/L was 53% lower in the active treatment group (P = 0.001). A greater rate of atrophy was associated with a lower final cognitive test scores. There was no difference in serious adverse events according to treatment category. Conclusions and Significance The accelerated rate of brain atrophy in elderly with mild cognitive impairment can be slowed by treatment with homocysteine-lowering B vitamins. Sixteen percent of those over 70 y old have mild cognitive impairment and half of these develop Alzheimer's disease. Since accelerated brain atrophy is a characteristic of subjects with mild cognitive impairment who convert to Alzheimer's disease, trials are needed to see if the same treatment will delay the development of Alzheimer's disease. Trial Registration Controlled-Trials.com ISRCTN94410159
Supranova Events from Spun-up Neutron Stars: An Explosion in Search of an Observation

We consider a formation scenario for supramassive neutron stars (SMNSs) that takes place through mass and angular momentum transfer from a close companion during a low-mass X-ray binary phase, with the ensuing suppression of the magnetic field. After the end of the mass transfer phase, SMNSs will lose, through magnetic dipole radiation, most of their angular momentum, triggering the star's collapse to a black hole. We discuss the rate of occurrence of these collapses and propose that these stars, because of the baryon-clear environment in which the implosion/explosion takes place, are the originators of gamma-ray bursts.
Can Recovery-Focused Multimodal Psychotherapy Facilitate Symptom and Function Improvement in People With Treatment-Resistant Psychotic Illness? A Comparison Study

Objective: To assess whether recovery-focused multimodal psychotherapy can facilitate symptom and function improvement in people with treatment-resistant psychotic illness. Method: Nine people with treatment-resistant schizophrenia or schizoaffective disorder whose symptoms and level of functioning necessitated inpatient care were engaged in individual multimodal psychotherapy for up to 21 months. In addition to the multimodal therapy they also received standard inpatient care. Twelve people retrospectively matched for diagnosis, age, sex, and chronicity of illness, formed a comparison group. They also received standard inpatient care. The standard inpatient care for both experimental and comparative groups consisted of custodial care, predominantly atypical antipsychotic drug therapy, and ongoing care from a key worker. Results: The treatment group showed clinically significant improvements in the overall Positive and Negative Symptom Scale (PANSS) scores which was significantly better than the changes found in the comparison group (p = 0.037). There was a 43% reduction in positive symptoms, a 30% reduction in negative symptoms, a 27.5% reduction in general psychopathology symptoms and a 30% reduction in overall scores on the PANSS. General behaviour scores on the Rehabilitation Evaluation of Hall and Baker were clinically improved, with a 32% reduction, as were deviant scores, with a 93.3% reduction. The change in the deviant scores was significantly better in the treatment group (p = 0.025). Conclusion: Recovery-focused multimodal psychotherapy may facilitate symptom and function improvement in people with treatment-resistant psychotic illness.
Dynamics of the plague–wildlife–human system in Central Asia are controlled by two epidemiological thresholds

Plague (caused by the bacterium Yersinia pestis) is a zoonotic reemerging infectious disease with reservoirs in rodent populations worldwide. Using one-half of a century of unique data (1949–1995) from Kazakhstan on plague dynamics, including data on the main rodent host reservoir (great gerbil), main vector (flea), human cases, and external (climate) conditions, we analyze the full ecoepidemiological (bubonic) plague system. We show that two epidemiological threshold quantities play key roles: one threshold relating to the dynamics in the host reservoir, and the second threshold relating to the spillover of the plague bacteria into the human population.
Hidden effects of chronic tuberculosis in African buffalo

Infectious diseases can bring about population declines and local host extinctions, contributing significantly to the global biodiversity crisis. Nonetheless, studies measuring population-level effects of pathogens in wild host populations are rare, and taxonomically biased toward avian hosts and macroparasitic infections. We investigated the effects of bovine tuberculosis (bTB), caused by the bacterial pathogen Mycobacterium bovis, on African buffalo (Syncerus caffer) at Hluhluwe-iMfolozi Park, South Africa. We tested 1180 buffalo for bTB infection between May 2000 and November 2001. Most infections were mild, confirming the chronic nature of the disease in buffalo. However, our data indicate that bTB affects both adult survival and fecundity. Using an age-structured population model, we demonstrate that the pathogen can reduce population growth rate drastically; yet its effects appear difficult to detect at the population level: bTB causes no conspicuous mass mortalities or fast population declines, nor.
GENETIC ANALYSIS OF THE C 677 T AND A 1298 C MTHFR POLYMORPHISMS IN A COHORT OF ROMANIAN PATIENTS WITH SPORADIC COLORECTAL CANCER 15

Background: One of the mutated genes associated with a lower level of 5MTHF necessary for DNA methylation and possibly implicated in the carcinogenesis of sporadic colorectal cancer (CRC) is the gene encoding the methylenetetrahydrofolate reductase enzyme (MTHFR). Objectives: to investigate the frequency of the C667T and A1298C MTHFR variants in patients with sporadic CRC and controls; to establish the relative risk for sporadic CRC in association with these two polymorphisms. Patients and methods: Genotyping of C677T and A1298C MTHFR polymorphisms using PCRRFLP methods was done in 69 patients diagnosed with CRC and referred from the Surgical Clinic III Cluj. Sixty seven individuals without any signs of malignancy formed the control group. Results: The CT677 and TT677 genotypes were greater in patients with sporadic CRC compared to controls (34.78% vs. 25.37%, OR 1.57; 95% CI [0.74-3.28], p=0.23 and 8.69% vs. 4.47%, OR 2.13; 95% CI [0.51-8.91], p=0.47, respectively). The 1298AC and CC1298 genotypes were associated with an OR of 1.63 (49.27% vs. 37.31%, 95% CI [0.82-3.23], p= 0.15) and 3.00 (4.34% vs. 1.49%, 95% CI [0.3-29.58], p=0.6) for sporadic CRC. Patients positive for C677T and A1298C polymorphisms have a higher frequency of colon cancer in the left side than in the right side (18.84% vs. 4.34%, OR 5.11, 95%CI [1.38-18.83], p< 0.01, and 23.18% vs. 10.14%, OR 2.67, 95%CI [1.02-6.98], p=0.03, respectively). Moreover, patients positive for C677T and A1298C polymorphisms have a higher frequency of colon cancer than rectal cancer (34.78% vs. 18.84%, OR 2.3, 95%CI [1.05-5.01], p= 0.03, and 28.98% vs. 15.94%, OR 2.15, 95%CI [0.94-4.92], p= 0.06, respectively). Conclusions: Our study confirms the relationship between MTHFR genotypes and sporadic colorectal cancer. High risk individuals could benefit from effective prevention and treatment with 5FU strategies in order to reduce the mortality of sporadic colorectal cancer.
Investigation of low-temperature electroluminescence of InGaN/GaN based nanorod light emitting arrays

For InGaN/GaN based nanorod devices using a top-down etching process, the optical output power is affected by non-radiative recombination due to sidewall defects (which decrease light output efficiency) and the mitigated quantum confined Stark effect (QCSE) due to strain relaxation (which increases internal quantum efficiency). Therefore, the exploration of low-temperature optical behaviors of nanorod light emitting diodes (LEDs) will help identify the correlation between these two factors. In this work, low-temperature electroluminescent (EL) spectra of InGaN/GaN nanorod arrays were explored and compared with those of planar LEDs. The nanorod LED exhibits a much higher optical output percentage increase when the temperature decreases. The increase is mainly attributed to the increased carriers in the quantum wells for radiative recombination. Also, due to a better spatial overlap of electrons and holes in the quantum wells, the increased number of carriers can be more efficiently recombined in the nanorod device. Next, while the nanorod array shows nearly constant peak energy in the EL spectra at various injection currents at the temperature of 300 K, a blue shift has been observed at 190 K. The results suggest that with less non-radiative recombination and thus more carriers in the quantum wells, carrier screening and band filling still prevail in the partially strain relaxed nanorods. Moreover, when the temperature drops to 77 K, the blue shift of both nanorod and planar devices disappears and the optical output power decreases since there are fewer carriers in the quantum wells for radiative recombination.
Work limitations among working persons with rheumatoid arthritis: results, reliability, and validity of the work limitations questionnaire in 836 patients.

OBJECTIVE To describe workplace limitations and the validity and reliability of the Work Limitations Questionnaire (WLQ) in persons with rheumatoid arthritis (RA). METHODS A total of 836 employed persons with RA reported clinical and work related measures and completed the WLQ, a 25 item questionnaire that assesses the impact of chronic health conditions on job performance and productivity. Limitations are categorized into 4 domains: physical demands (PDS), mental demands (MDS), time management demands (TMS), and output demands (ODS), which are then used to calculate the WLQ index. RESULTS Of the 836 completed WLQ, about 10% (85) could not be scored, as more than half the items in each domain were not applicable to the patient's job. Demographic and clinical variables were associated with missing WLQ scores including older age (OR 1.7, 95% CI 1.3-2.1), male sex (OR 1.9, 95% CI 1.2-3.0), and Health Assessment Questionnaire (HAQ) scores (OR 1.4, 95% CI 1.0-2.0). Work limitations were present in all work domains: PDS (27.5%), MDS (15.7%), ODS (19.4%), and TMS (28.6%), resulting in a mean WLQ index of 5.9 (SD 5.6), which corresponds to a 4.9% decrease in productivity and a 5.1% increase in work hours to compensate for productivity loss. The WLQ index was inversely associated with Medical Outcomes Study Short Form 36 (SF-36) Mental Component Score (MCS; r = -0.60) and Physical Component Score (PCS; r = -0.49). Fatigue (0.5), pain (0.46), and HAQ (0.56) were also significantly associated with the WLQ index. Weaker associations were seen with days unable to perform (0.29), days activities cut down (0.38), and annual income (-0.10). CONCLUSION The WLQ is a reliable tool for assessing work productivity. However, persons with RA tend to select jobs that they can do with their RA limitations, with the result that the WLQ does not detect functional limitations as well as the HAQ and SF-36. The WLQ provides special information that is not available using conventional measures of assessment, and can provide helpful knowledge about individual patient problems in the workplace. Whether this information will have greater predictive ability and clinical relevance compared with surrogate measures such as the HAQ and SF-36 has not been determined, but should be the subject of future studies.
Structural and Logical Analysis of a Comprehensive Hedgehog Signaling Pathway to Identify Alternative Drug Targets for Glioma, Colon and Pancreatic Cancer

Hedgehog is an evolutionarily conserved developmental pathway, widely implicated in controlling various cellular responses such as cellular proliferation and stem cell renewal in human and other organisms, through external stimuli. Aberrant activation of this pathway in human adult stem cell line may cause different types of cancers. Hence, targeting this pathway in cancer therapy has become indispensable, but the non availability of detailed molecular interactions, complex regulations by extra- and intra-cellular proteins and cross talks with other pathways pose a serious challenge to get a coherent understanding of this signaling pathway for making therapeutic strategy. This motivated us to perform a computational study of the pathway and to identify probable drug targets. In this work, from available databases and literature, we reconstructed a complete hedgehog pathway which reports the largest number of molecules and interactions to date. Using recently developed computational techniques, we further performed structural and logical analysis of this pathway. In structural analysis, the connectivity and centrality parameters were calculated to identify the important proteins from the network. To capture the regulations of the molecules, we developed a master Boolean model of all the interactions between the proteins and created different cancer scenarios, such as Glioma, Colon and Pancreatic. We performed perturbation analysis on these cancer conditions to identify the important and minimal combinations of proteins that can be used as drug targets. From our study we observed the under expressions of various oncoproteins in Hedgehog pathway while perturbing at a time the combinations of the proteins GLI1, GLI2 and SMO in Glioma; SMO, HFU, ULK3 and RAS in Colon cancer; SMO, HFU, ULK3, RAS and ERK12 in Pancreatic cancer. This reconstructed Hedgehog signaling pathway and the computational analysis for identifying new combinatory drug targets will be useful for future in-vitro and in-vivo analysis to control different cancers.
Information-theoretic criterion for the performance of single-photon avalanche photodiodes

A channel-capacity metric is introduced for assessing the performance of single-photon avalanche photodiodes (SPADs) when used as detectors in laser communication systems. This metric is employed to theoretically optimize, with respect to the device structure and operating voltage, the performance of SPADs with simple InP or In/sub 0.52/Al/sub 0.48/As-InP heterojunction multiplication regions. As the multiplication-region width increases, an increase is predicted in both the peak and the full-width at half-maximum of the channel capacity curve versus the normalized excess voltage. Calculations also show the existence of an optimal In/sub 0.52/Al/sub 0.48/As-InP heterojunction multiplication region that maximizes the peak channel capacity beyond that of InP.
Associative Memory via a Sparse Recovery Model

An associative memory is a structure learned from a dataset M of vectors (signals) in a way such that, given a noisy version of one of the vectors as input, the nearest valid vector from M (nearest neighbor) is provided as output, preferably via a fast iterative algorithm. Traditionally, binary (or q-ary) Hopfield neural networks are used to model the above structure. In this paper, for the first time, we propose a model of associative memory based on sparse recovery of signals. Our basic premise is simple. For a dataset, we learn a set of linear constraints that every vector in the dataset must satisfy. Provided these linear constraints possess some special properties, it is possible to cast the task of finding nearest neighbor as a sparse recovery problem. Assuming generic random models for the dataset, we show that it is possible to store super-polynomial or exponential number of n-length vectors in a neural network of size O(n). Furthermore, given a noisy version of one of the stored vectors corrupted in near-linear number of coordinates, the vector can be correctly recalled using a neurally feasible algorithm.
Soil Carbon and Nitrogen Changes in Forests of Walker Branch Watershed, 1972 to 2004

Changes in soil C and N concentrations and contents in four samplings during a 32-yr period on Walker Branch watershed in Tennessee were determined and compared with previously measured C and N fluxes and with changes in ecosystem C and N pools during this period. Soils showed significant increases in C and N concentrations in surface horizons from 1972 to 2004, and most of this increase occurred between 1972 and 1982. A previously observed decline in soil C and N contents between 1982 and 1993 was reversed in 2004 such that the latter increased to near 1982 values. The changes in soil C content could be approximately accounted for by previously measured litterfall and soil C0 2 -C fluxes. Changes in soil N could not be accounted for by leaching, increments in vegetation, or by laboratory bias, changes during sample storage, or reasonable estimates of field sampling errors. We conclude that, although vegetation C and N pools increased steadily during the sampling period in most cases, changes in soil C and N pools on Walker Branch watershed are highly variable in both space and time, and there has been no unidirectional trend during the time period of this study.