Miracle-dz/UniFAR-FTUs huggingface dataset:
Retinoids and sebaceous gland activity.

BACKGROUND AND OBJECTIVE The marked efficacy of isotretinoin in the treatment of acne is undoubtedly due to its potential to inhibit sebaceous gland activity. The question arises if the anti-acne effect of new oral retinoids can be predicted by using the currently available experimental models. METHODS We reviewed the effects of various oral retinoids on sebum excretion in humans and their efficacy in acne. The human data were compared to the results obtained from in vitro and animal models. RESULTS Oral retinoids such as etretinate, acitretin and the so-called arotinoids were not able to inhibit the sebum production in humans and were ineffective against acne. In various animal models (i.e. sebum production in rats, flank organ size in hamsters, ear sebaceous gland size in hamster, most of these retinoids were shown to be effective. Furthermore, in addition to isotretinoin, some retinoids were able to suppress the proliferation of human sebocytes in vitro. CONCLUSIONS The elucidation of the mechanism of action of isotretinoin on the sebocyte biology is critical for the search of more reliable models and for the discovery of new retinoids with anti-acne activity.
Predictors of return-to-work in patients with chronic musculoskeletal pain: A randomized clinical trial.

OBJECTIVE To assess the predictive effect of a multidisciplinary intervention programme, pain, work-related factors and health, including anxiety/depression and beliefs, on return-to-work for patients sick-listed due to musculoskeletal pain. DESIGN A randomized clinical study. METHODS A total of 284 patients were randomized to either a multidisciplinary intervention programme (n = 141) or to a less resource-demanding brief intervention (n = 143). Work participation was estimated monthly from register data for 12 months. Return-to-work was defined as increased work participation in 3 consecutive months. RESULTS In the adjusted model, return-to-work by 3 months was associated with a multidisciplinary intervention programme (odds ratio (OR) = 2.7, 95% confidence interval (95% CI) = 1.1-6.9), the factor "belief that work was cause of the pain" (OR = 2.2, 95% CI = 1.1-4.3), anxiety and depression (OR = 0.5, 95% CI = 0.2-0.98), and by an interaction between the multidisciplinary intervention and perceived support at work (OR = 0.3, 95% CI = 0.1-0.9). At 12 months, only duration of sick leave was associated with return-to-work (OR = 0.6, 95% CI = 0.5-0.8). CONCLUSION Multidisciplinary intervention may hasten return-to-work and benefit those who perceive low support at work, but at 12 months only duration of sick leave at baseline was associated with return-to-work.
Transmission Dynamics of Schistosoma japonicum in the Lakes and Marshlands of China

Background Schistosoma japonicum is a major public health concern in China, with over one million people infected and another 40 million living in areas at risk of infection. Unlike the disease caused by S. mansoni and S. haematobium, schistosomiasis japonica is a zoonosis, involving a number of different mammalian species as reservoir hosts. As a result of a number of published reports from China, it has long been considered that bovines, particularly water buffaloes, play a major role in human S. japonicum transmission there, and a drug-based intervention study (1998–2003) around the Poyang Lake in Jiangxi Province provided proof of concept that water buffaloes are, indeed, major reservoirs of human infection in this setting. Methods and Findings In this study we incorporated recently obtained epidemiological information to model the steady-state S. japonicum transmission as well as the impact of the removal of S. japonicum transmission attributable to water buffaloes on human infection rates across six different endemic scenarios within three villages in the Dongting (Hunan) and Poyang (Jiangxi) lakes of southern China. Similar results were obtained for all scenarios. Steady-state S. japonicum infection rates remained constant and human prevalence and incidence were predicted to fall considerably over time. The model showed that the contribution of S. japonicum water buffalo transmission to human infection ranged from 39.1% to 99.1% and predicted that the removal of water buffalo transmission would reduce parasite reproductive rates below 1. This indicates that without the contribution of water buffaloes, S. japonicum transmission is interrupted and unsustainable. These scenarios are generalizable to other endemic villages in the lake and marshland areas of China where a similar cycle of snail infection and infection/reinfection of humans and bovines occurs. Conclusions Along with previous epidemiological data, our findings strongly support water buffaloes as an important component of the transmission cycle that affects humans in the lake and marshlands region of China, a feature which appears to differ from the situation prevalent in the Philippines where their contribution is less pronounced. Our conclusions underscore the rationale for removal, replacement or treatment of water buffaloes, and for the development and deployment of a transmission blocking buffalo vaccine against S. japonicum for this setting to achieve the goal of transmission control. The Chinese Government has recently commenced a new integrated national strategy to improve on existing approaches to control schistosomiasis in the lake and marshlands region by reducing bovines and humans as a source of S. japonicum infection to Oncomelania snails.
Genome-Wide Association Studies and Comparison of Models and Cross-Validation Strategies for Genomic Prediction of Quality Traits in Advanced Winter Wheat Breeding Lines

The aim of the this study was to identify SNP markers associated with five important wheat quality traits (grain protein content, Zeleny sedimentation, test weight, thousand-kernel weight, and falling number), and to investigate the predictive abilities of GBLUP and Bayesian Power Lasso models for genomic prediction of these traits. In total, 635 winter wheat lines from two breeding cycles in the Danish plant breeding company Nordic Seed A/S were phenotyped for the quality traits and genotyped for 10,802 SNPs. GWAS were performed using single marker regression and Bayesian Power Lasso models. SNPs with large effects on Zeleny sedimentation were found on chromosome 1B, 1D, and 5D. However, GWAS failed to identify single SNPs with significant effects on the other traits, indicating that these traits were controlled by many QTL with small effects. The predictive abilities of the models for genomic prediction were studied using different cross-validation strategies. Leave-One-Out cross-validations resulted in correlations between observed phenotypes corrected for fixed effects and genomic estimated breeding values of 0.50 for grain protein content, 0.66 for thousand-kernel weight, 0.70 for falling number, 0.71 for test weight, and 0.79 for Zeleny sedimentation. Alternative cross-validations showed that the genetic relationship between lines in training and validation sets had a bigger impact on predictive abilities than the number of lines included in the training set. Using Bayesian Power Lasso instead of GBLUP models, gave similar or slightly higher predictive abilities. Genomic prediction based on all SNPs was more effective than prediction based on few associated SNPs.
Essential oil of Croton Zehntneri attenuates lung injury in the OVA-induced asthma model

ABSTRACT Objective: Croton zehntneri Pax et Hoffm. is a Euphorbiaceae species, popularly known as “canela de cunhã,” a native plant of northeastern Brazil, whose essential oil (EOCZ) shows relatively specific myorelaxant action for the smooth muscle of the airways and in the respiratory tract. Based on this information, EOCZ figures as a candidate for testing in the treatment of asthma, and the present study investigated the benefits of using EOCZ in an ovalbumin-induced asthma model. Methods: 48 male BALB/c mice were divided into six groups (n = 8). In the ST, SO100, and SO300 groups, mice were sensitized and challenged with saline, and then treated with 200 µL of 0.1% Tween 80, 100 mg/kg EOCZ and 300 mg/kg EOCZ, respectively. In the OT, OO100, and OO300 groups, mice were sensitized and challenged with OVA, and then treated with 200 µL of 0.1% Tween 80, 100 mg/kg EOCZ and 300 mg/kg EOCZ, respectively. Results: Our results demonstrated significant changes in all respiratory mechanics variables analyzed between the OO300 and OT groups demonstrating the effectiveness of EOCZ to attenuate the OVA-induced lung injury. In addition, the use of EOCZ at a dose of 300 mg/kg showed an antioxidant effect and decreased inflammatory cells in the pulmonary parenchyma. In conclusion, our results demonstrated that EOCZ was able to improve the lesion in the respiratory system of mice subjected to OVA-induced asthma. Conclusions: The antioxidant action of EOCZ was likely the main mechanism of action in the reversal of this lesion, so more tests should be performed for its confirmation.
Comparison of therapeutic effect of aqueous extract of garlic and nystatin mouthwash in denture stomatitis.

INTRODUCTION Denture stomatitis (DS) is the most common form of chronic oral candidiasis. The standard treatment for DS is nystatin, which is accompanied with complications such as a bitter taste. The aim of this study was to compare the effect of garlic with nystatin in DS. MATERIAL AND METHODS This randomised clinical trial study was performed on 40 patients with DS. After obtaining written consent, patients were divided into two groups while members of each group were given either nystatin or garlic extract for 4 weeks. The length and width of erythema area was measured at the end of the first, second, third, and the fourth weeks using a calliper. Data were analysed by SPSS and statistical tests including variance analysis with anova repeated measures, chi-square, and least square differences. RESULTS The changes in the length and width of erythema at different times according to the type of treatment were found to be significant while an accelerated recovery was demonstrated for nystatin (p < 0.001). Both regimens resulted in significant recovery (p < 0.0001). Greater satisfaction with the use of garlic rather than nystatin was mentioned (p < 0.0001). CONCLUSION Considering the efficacy of garlic and lack of side effects for this compound and also regarding the nystatin-associated complications, garlic extract can be introduced as a substitution for standard treatment in DS.
Awareness of cognitive and social behaviour in a CSCL environment

Most distributed and virtual online environments for and pedagogies of computer-supported collaborative learning CSCL neglect the social and social-emotional aspects underlying the group dynamics of learning and working in a CSCL group. These group dynamics often determine whether the group will develop into a well-performing team and whether a sound social space emerges. Using a theory-based CSCL framework, two studies evaluated whether two tools, Radar and Reflector, supported cognitive, social and socio-emotional aspects of team development, encouraging promotive interaction and group processing in the teams. While not affecting product quality, tool use did lead to groups who perceived their team as being better developed, as having higher levels of group satisfaction and lower levels of conflicts. The results support that promotive interaction and group processing was increased by using Radar and Reflector.
Sources and geographical origins of fine aerosols in Paris (France)

The present study aims at identifying and apportioning fine aerosols to their major sources in Paris (France) – the second most populated "larger urban zone" in Europe – and determining their geographical origins. It is based on the daily chemical composition of PM2.5 examined over 1 year at an urban background site of Paris (Bressi et al., 2013). Positive matrix factorization (EPA PMF3.0) was used to identify and apportion fine aerosols to their sources; bootstrapping was performed to determine the adequate number of PMF factors, and statistics (root mean square error, coefficient of determination, etc.) were examined to better model PM2.5 mass and chemical components. Potential source contribution function (PSCF) and conditional probability function (CPF) allowed the geographical origins of the sources to be assessed; special attention was paid to implement suitable weighting functions. Seven factors, namely ammonium sulfate (A.S.)-rich factor, ammonium nitrate (A.N.)-rich factor, heavy oil combustion, road traffic, biomass burning, marine aerosols and metal industry, were identified; a detailed discussion of their chemical characteristics is reported. They contribute 27, 24, 17, 14, 12, 6 and 1% of PM2.5 mass (14.7 μg m−3) respectively on the annual average; their seasonal variability is discussed. The A.S. - and A.N. -rich factors have undergone mid- or long-range transport from continental Europe; heavy oil combustion mainly stems from northern France and the English Channel, whereas road traffic and biomass burning are primarily locally emitted. Therefore, on average more than half of PM2.5 mass measured in the city of Paris is due to mid- or long-range transport of secondary aerosols stemming from continental Europe, whereas local sources only contribute a quarter of the annual averaged mass. These results imply that fine-aerosol abatement policies conducted at the local scale may not be sufficient to notably reduce PM2.5 levels at urban background sites in Paris, suggesting instead more coordinated strategies amongst neighbouring countries. Similar conclusions might be drawn in other continental urban background sites given the transboundary nature of PM2.5 pollution.
Stroke Prevention: Managing Modifiable Risk Factors

Prevention plays a crucial role in counteracting morbidity and mortality related to ischemic stroke. It has been estimated that 50% of stroke are preventable through control of modifiable risk factors and lifestyle changes. Antihypertensive treatment is recommended for both prevention of recurrent stroke and other vascular events. The use of antiplatelets and statins has been shown to reduce the risk of recurrent stroke and other vascular events. Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs) are indicated in stroke prevention because they also promote vascular health. Effective secondary-prevention strategies for selected patients include carotid revascularization for high-grade carotid stenosis and vitamin K antagonist treatment for atrial fibrillation. The results of recent clinical trials investigating new anticoagulants (factor Xa inhibitors and direct thrombin inhibitors) clearly indicate alternative strategies in stroke prevention for patients with atrial fibrillation. This paper describes the current landscape and developments in stroke prevention with special reference to medical treatment in secondary prevention of ischemic stroke.
A retrospective observational analysis of post-pandemic influenza-related outcomes in the United Kingdom, 2010–2014

ABSTRACT This study set out to evaluate influenza- and respiratory-related illnesses recorded during primary care physician consultations in England following the H1N1 pandemic in 2009 and to enable the development of a dynamic disease model. Data were obtained from the Clinical Practice Research Datalink of primary care records over four influenza seasons (2010–2014). The primary outcome of the study was incidence of influenza- and respiratory-related diagnoses, calculated per practice and by season and age group. Upper respiratory tract infection diagnoses were most frequently recorded (mean seasonal practice level incidence; 3,762 consultations per 100,000 [SD = 1,989]), and influenza-related diagnoses were least frequently recorded across all seasons, except one. Incidence rates for the under 18 population were higher than those for the general population, in particular for upper respiratory tract infection (range of 8,024–9,950 versus 3,228–4,120, respectively) and otitis media diagnoses (2,668–3,652 versus 782–1,057, respectively). For influenza-related diagnoses, the 65+ age group, the 0 to <2 and 2 to <4 groups had a higher risk (risk ratio = 1.33, 1.12 and 1.16, respectively) than other age groups. This study provides valuable insight into the incidence of influenza- and respiratory-related diagnoses in the primary care setting in England, and suggests a higher burden of disease in young children and the elderly. The study also indicates that some influenza illness is likely to be reported under respiratory-related diagnoses, given the low incidence of influenza-related diagnoses in the study.
Sea Surface Temperature changes analysis, an Essential Climate Variable for Ecosystem Services provisioning

Sea Surface Temperature is an Essential Climate Variable (ECV) that allows an effective quantitative estimation of recent changes in large marine ecosystem like the Mediterranean Sea. Sea Surface Temperature (SST) continues to rise, threatening marine ecosystem status and Ecosystem Services (ESS) provisioning. One of the questions that multitemporal analysis of Earth Observation (EO) time series should address is the response to variations in SST spatial distribution due to climate change. Ecosystem indicators like the fish growth rates across Mediterranean regions reveal temporal trends and regional variability. This study addresses the changes of the SST of the Mediterranean Sea “Large Marine Ecosystem” over the last three decades in order to evaluate trends, identify spatial and temporal patterns of SST variability from multitemporal analysis of EO products. Time series of daily SST estimated for the period 1982–2016 from multi-sensor satellite data were collected from operational Copernicus Marine Environment Monitoring Service (CMEMS). A wide range of statistical approaches are considered, like Seasonal Trend decomposition, Empirical Orthogonal Function, Self-Organizing Maps. Focusing on the thermal habitat of fish species, a fish growth model is used to reveal different scenarios in the potential growth of fish populations under past and current conditions as well as future climate projections. Results indicate that in the past three decades the eastern part of the Mediterranean Sea experienced greater SST increase than the western part, producing different scenarios of fish growth rates across the Mediterranean regions.
Fast and compact elliptic-curve cryptography

Elliptic curve cryptosystems have improved greatly in speed over the past few years. In this paper we outline a new elliptic curve signature and key agreement implementation. We achieve record speeds for signatures while remaining relatively compact. For example, on Intel Sandy Bridge, a curve with about 2250 points produces a signature in just under 60k clock cycles, verifies in under 169k clock cycles, and computes a Diffie-Hellman shared secret in under 153k clock cycles. Our implementation has a small footprint: the library is under 55kB. We also post competitive timings on ARM processors, verifying a signature in under 618k Tegra-2 cycles. We introduce faster field arithmetic, a new point compression algorithm, an improved fixed-base scalar multiplication algorithm and a new way to verify signatures without inversions or coordinate recovery. Some of these improvements should be applicable to other systems.
Imaging of Single and Double Scatterers in Urban Areas via SAR Tomography

Microwave scattering is a rather complex mechanism, especially in urban areas. Three-dimensional (3-D) synthetic aperture radar (SAR) tomography is a technique that uses multiple views to map the scattering power at different heights, thus extending the capability of SAR sensors to fully image the scene in the 3-D space. This paper presents a first validation of spaceborne long-term SAR tomography by demonstrating the capability to resolve a simple layover case, i.e., to separate single- and double-scattering mechanisms within imaged pixels. Results obtained with real data acquired by the European Remote Sensing 1 and 2 (ERS-1 and ERS-2) satellites over the urban area of Napoli are presented. As an additional contribution, an innovative algorithm estimating residual topography and surface deformation, called the spatial-differencing technique, is also discussed in detail at the data calibration stage
Fatigue of shot peened 7075‐T7351 SENB specimen – A 3‐D analysis

As-received or shot peened 7075-T7351 single-edged notch bend (SENB) specimens, 8.1-mm thick, were fatigued at a constant maximum load and at stress ratios of R = 0.1 and 0.8 to predetermined numbers of fatigue cycles or to failure. The SENB specimens were then fractured by overload and the tunnelling crack profiles were recorded. The crack-growth rate, da/dN, after crack initiation at the notch was determined by crack-profile measurement and fractography at various fatigue cycles. The shot peened surface topography and roughness was also evaluated by three-dimensional (3-D) laser scanning microscopy. Residual stresses in the as-received specimens and those generated by shot peening at Almen scales of 0.004A, 0.008A, 0.012A and 0.016A, were measured by an X-ray diffraction stress analyser with an X-ray target, CrK, every 0.1 mm to a depth of 1 mm. The 3-D stress intensity factor of the curved crack front was determined by the superposition of the 3-D finite element solutions of the stress intensity factor of the loaded SENB specimen without the residual stress and the stress intensity factor of the unloaded SENB specimen with a prescribed residual stress distribution. da/dN versus the resultant stress intensity factor amplitude, ΔK I , plots showed that while the residual stress locally retarded the crack-growth rate it had no effect on the overall crack-propagation rate.
Evaluation of the Antipsoriatic Activity of Aloe Vera Leaf Extract Using a Mouse Tail Model of Psoriasis

Aloe vera gel is used traditionally for the treatment of skin diseases, including psoriasis. An ethanolic extract of the gel was assessed for antipsoriatic activity using a mouse tail model of psoriasis. The extract produced a significant differentiation in the epidermis, as seen from its degree of orthokeratosis (85.07 ± 3.36%) when compared with the negative control (17.30 ± 4.09%). This was equivalent to the effect of the standard positive control, tazarotene (0.1%) gel, which showed a 90.03 ± 2.00% degree of orthokeratosis. The ethanolic extract of Aloe vera leaf gel also produced a significant increase in relative epidermal thickness when compared with the control group, whereas the standard tazarotene showed no change. Taken together, the extract showed an overall antipsoriatic activity of 81.95%, compared with 87.94 for tazarotene, in the mouse tail model for psoriasis. Copyright © 2011 John Wiley & Sons, Ltd.