Miracle-dz/UniFAR-FTUs huggingface dataset:
A Novel H19 Antisense RNA Overexpressed in Breast Cancer Contributes to Paternal IGF2 Expression

ABSTRACT The H19/IGFf2 locus belongs to a large imprinted domain located on human chromosome 11p15.5 (homologue to mouse distal chromosome 7). The H19 gene is expressed from the maternal allele, while IGF2 is paternally expressed. Natural antisense transcripts and intergenic transcription have been involved in many aspects of eukaryotic gene expression, including genomic imprinting and RNA interference. However, apart from the identification of some IGF2 antisense transcripts, few data are available on that topic at the H19/IGF2 locus. We identify here a novel transcriptional activity at both the human and the mouse H19/IGF2 imprinted loci. This activity occurs antisense to the H19 gene and has the potential to produce a single 120-kb transcript that we called the 91H RNA. This nuclear and short-lived RNA is not imprinted in mouse but is expressed predominantly from the maternal allele in both mice and humans within the H19 gene region. Moreover, the transcript is stabilized in breast cancer cells and overexpressed in human breast tumors. Finally, knockdown experiments showed that, in humans, 91H, rather than affecting H19 expression, regulates IGF2 expression in trans.
Modeling and centralized sliding mode control of a two-flexible-link robot

In many applications, the use of slender and light flexible structures has increased due to the requirement of more efficient structures. One objective of this work is to generate an approximated model of a two flexible-link robot for control purposes, which includes rotational actuators, piezoelectric actuators, and different kinds of sensors (acceleration and deformation). The model is obtained under a classical mechanics approach: Lagrange Euler energy balance. The model of the actuators is also included. Some parts of the resulting model involving integral terms are calculated using symbolic programming software, whereas other parts are implemented and calculated dynamically during simulation. The model of the two flexible-link robot is simplified for the controller calculation. The resulting model is simulated in Matlab/Simulink. The second objective is to develop a MIMO joint tracking and active vibration sliding mode controller. The values required for the implementation of the controller are obtained from the formulated models. Experimental results show the effectiveness of the proposed controllers.
Efficient Structured Inference for Transition-Based Parsing with Neural Networks and Error States

Transition-based approaches based on local classification are attractive for dependency parsing due to their simplicity and speed, despite producing results slightly below the state-of-the-art. In this paper, we propose a new approach for approximate structured inference for transition-based parsing that produces scores suitable for global scoring using local models. This is accomplished with the introduction of error states in local training, which add information about incorrect derivation paths typically left out completely in locally-trained models. Using neural networks for our local classifiers, our approach achieves 93.61% accuracy for transition-based dependency parsing in English.
Perceptions of corporate social responsibility, organizational commitment and job satisfaction

Purpose – This paper aims to, first, investigate the impact of corporate social responsibility (CSR)’s various dimensions on organizational commitment and job satisfaction, and, second, to examine the moderating role of employee expectations in this relationship. Studies have increasingly focused the attention on the links between perceptions of CSR and employees’ attitudes. However, a majority of studies do concentrate on internal CSR impact. Design/methodology/approach – A field study based on data from 621 workers. The constructs were measured by validated self-report questionnaires. Findings – The results show that ethical and legal internal and external practices significantly influence the affective organizational commitment. The results also indicate that job satisfaction is positively influenced by internal and external ethico-legal practices as well as by philanthropic practices. Nonetheless, the role of expectation as moderator could not be demonstrated. This matter is discussed in the section d.
Light to Moderate Alcohol Consumption Is Protective for Type 2 Diabetes Mellitus in Normal Weight and Overweight Individuals but Not the Obese

Objective. To examine the association between alcohol consumption and risk of type 2 diabetes mellitus (T2DM) overall and by body mass index. Methods. Cross-sectional study of employed individuals. Daily alcohol intakes were calculated from a self-administered food frequency questionnaire by 5,512 Maori, Pacific Island, and European workers (3,992 men, 1520 women) aged 40 years and above. Results. There were 170 new cases of T2DM. Compared to the group with no alcohol consumption and adjusting for age, sex, and ethnicity, the group consuming alcohol had relative risks of T2DM of 0.23 (95% CI: 0.08, 0.65) in normal weight individuals, 0.38 (0.18, 0.81) in overweight individuals, and 0.99 (0.59, 1.67) in obese individuals. After further adjusting for total cholesterol, HDL-cholesterol, triglycerides, smoking habit, physical activity, socioeconomic status, body mass index, and hypertension, the relative risks of T2DM were 0.16 (0.05, 0.50) in normal weight individuals, 0.43 (0.19, 0.97) in overweight individuals, and 0.92 (0.52, 1.60) in overweight individuals. Across the categories of alcohol consumption, there was an approximate U-shaped relationship for new cases of T2DM. There was no significant association between alcohol consumption and IGT. Conclusions. Alcohol consumption was protective against diagnosis of T2DM in normal and overweight individuals but not in the obese.
Exploratory Metabolomic Analyses Reveal Compounds Correlated with Lutein Concentration in Frontal Cortex, Hippocampus, and Occipital Cortex of Human Infant Brain

Lutein is a dietary carotenoid well known for its role as an antioxidant in the macula, and recent reports implicate a role for lutein in cognitive function. Lutein is the dominant carotenoid in both pediatric and geriatric brain tissue. In addition, cognitive function in older adults correlated with macular and postmortem brain lutein concentrations. Furthermore, lutein was found to preferentially accumulate in the infant brain in comparison to other carotenoids that are predominant in diet. While lutein is consistently related to cognitive function, the mechanisms by which lutein may influence cognition are not clear. In an effort to identify potential mechanisms through which lutein might influence neurodevelopment, an exploratory study relating metabolite signatures and lutein was completed. Post-mortem metabolomic analyses were performed on human infant brain tissues in three regions important for learning and memory: the frontal cortex, hippocampus, and occipital cortex. Metabolomic profiles were compared to lutein concentration, and correlations were identified and reported here. A total of 1276 correlations were carried out across all brain regions. Of 427 metabolites analyzed, 257 were metabolites of known identity. Unidentified metabolite correlations (510) were excluded. In addition, moderate correlations with xenobiotic relationships (2) or those driven by single outliers (3) were excluded from further study. Lutein concentrations correlated with lipid pathway metabolites, energy pathway metabolites, brain osmolytes, amino acid neurotransmitters, and the antioxidant homocarnosine. These correlations were often brain region—specific. Revealing relationships between lutein and metabolic pathways may help identify potential candidates on which to complete further analyses and may shed light on important roles of lutein in the human brain during development.
Decentralized Parameter Estimation by Consensus Based Stochastic Approximation

In this paper, an algorithm for decentralized multi-agent estimation of parameters in linear discrete-time regression models is proposed in the form of a combination of local stochastic approximation algorithms and a global consensus strategy. An analysis of the asymptotic properties of the proposed algorithm is presented, taking into account both the multi-agent network structure and the probabilities of getting local measurements and implementing exchange of inter-agent messages. In the case of non-vanishing gains in the stochastic approximation algorithms, an asymptotic estimation error covariance matrix bound is defined as the solution of a Lyapunov-like matrix equation. In the case of asymptotically vanishing gains, the mean-square convergence is proved and the rate of convergence estimated. In the discussion, the problem of additive communication noise is treated in a methodologically consistent way. It is also demonstrated how the consensus scheme in the algorithm can contribute to the overall reduction of measurement noise influence. Some simulation results illustrate the obtained theoretical results.
Polymer Combustion as a Basis for Hybrid Propulsion: A Comprehensive Review and New Numerical Approaches

Hybrid Propulsion is an attractive alternative to conventional liquid and solid rocket motors. This is an active area of research and technological developments. Potential wide application of Hybrid Engines opens the possibility for safer and more flexible space vehicle launching and manoeuvring. The present paper discusses fundamental combustion issues related to further development of Hybrid Rockets. The emphasis is made on the two aspects: (1) properties of potential polymeric fuels, and their modification, and (2) implementation of comprehensive CFD models for combustion in Hybrid Engines. Fundamentals of polymeric fuel combustion are discussed. Further, steps necessary to accurately describe their burning behaviour by means of CFD models are investigated. Final part of the paper presents results of preliminary CFD simulations of fuel burning process in Hybrid Engine using a simplified set-up.
A Midwifery Model of Care for Childbearing Women at High Risk: Genuine Caring in Caring for the Genuine

According to this paper’s synthesis of research, three constituents of ideal midwifery care emerge. First, a dignity-protective action takes place in a midwife’s caring relationship with a childbearing woman at high risk and includes mutuality, trust, ongoing dialogue, enduring presence, and shared responsibility. Secondly, the midwife’s embodied knowledge is based on genuineness to oneself and consists of theoretical, practical, intuitive, and reflective knowledge. Finally, nurse-midwives have a special responsibility to balance the natural and medical perspectives in the care of childbearing women at high risk, especially by promoting the woman’s inborn capacity to be a mother and to give birth in a natural manner. This midwifery model of care is labeled “Genuine Caring in Caring for the Genuine. ” Here, the word genuine expresses the nature of midwifery care, as well as the nature of each pregnant woman being cared for as a unique individual.
Methylenedioxymethamphetamine inhibits mitochondrial complex I activity in mice: a possible mechanism underlying neurotoxicity

Background and purpose: 3,4‐methylenedioxymethamphetamine (MDMA) causes a persistent loss of dopaminergic cell bodies in the substantia nigra of mice. Current evidence indicates that such neurotoxicity is due to oxidative stress but the source of free radicals remains unknown. Inhibition of mitochondrial electron transport chain complexes by MDMA was assessed as a possible source.
Employee Satisfaction of SAINSBURY'S An Exploratory Study

This paper focuses on employee satisfaction with reward system at UK retail industry considering SAINSBURY’S as the prime case. The sample was drawn randomly from SAINSBURY’S store. A structured questionnaire was used to collect data. The results showed that the employees of the company were happy with the reward system. An issue of strategies significance was revealed in the survey that employees kept themselves aware of the marker reward system, so the employers should strive hard to continuously improve the reword system of the company.
Evaluation of TB Case Finding through Systematic Contact Investigation, Chhattisgarh, India

Rationale. Contact investigation is an established tool for early case detection of tuberculosis (TB). In India, contact investigation is not often conducted, despite national policy, and the yield of contact investigation is not well described. Objective. To determine the yield of evaluating household contacts of sputum smear-positive TB cases in Rajnandgaon district, Chhattisgarh, India. Methods. Among 14 public health care facilities with sputum smear microscopy services, home visits were conducted to identify household contacts of all registered sputum smear-positive TB cases. We used a standardized protocol to screen for clinical symptoms suggestive of active TB with additional referral for chest radiograph and sputa collection. Results. From December 2010 to May 2011, 1,556 household contacts of 312 sputum smear-positive TB cases were identified, of which 148 (9.5%) were symptomatic. Among these, 109 (73.6%) were evaluated by sputum examination resulting in 11 cases (10.1%) of sputum smear-positive TB and 4 cases (3.6%) of smear-negative TB. Household visits contributed additional 63% TB cases compared to passive case detection alone. Conclusion. A standard procedure for conducting household contact investigation identified additional TB cases in the community and offered an opportunity to initiate isoniazid chemoprophylaxis among children.
Trastornos de Personalidad en Hombres Maltratadores a la Pareja: Perfil Diferencial entre Agresores en Prisión y Agresores con Suspensión de Condena

In this paper a study of personality disorders most frequently related to 217 male batterers is carried out. All of them form part of a specialized psychological treatment programme for gender violence, which is developed by PSIMAE Institute of Forensic and Legal Psychology, belonging to the Social Service of Justice, Government of Navarra (Spain). All the participants were assessed with the MCMI-II before beginning the treatment programme. Furthermore, a comparison of all the personality variables studied among the subjects referred by the court to the treatment programme (137 males with a suspended sentence) and those who were imprisoned (n = 80) was conducted. According to the results, 79.3% of the sample showed at least one personality disorder. The most prevalent one was the obsessive-compulsive personality disorder (61.3% of cases), followed by the paranoid personality disorder (30%) and the dependent personality disorder (28.1% of cases). Moreover, the results showed the existence of numerous statistically significant differences between groups. In general, imprisoned batterers showed a higher severity in personality variables than those who were referred by the court to the treatment programme. Implications of these results for further research and clinical practice are also commented.
Safety and Pharmacokinetics of Once-Daily Regimens of Soft-Gel Capsule Saquinavir plus Minidose Ritonavir in Human Immunodeficiency Virus-Negative Adults

ABSTRACT Human immunodeficiency virus type 1 (HIV-1) protease inhibitors have dramatically improved treatment options for HIV infection, but frequent dosing may impact adherence to highly active antiretroviral treatment regimens (HAART). Previous studies demonstrated that combined therapy with ritonavir and saquinavir allows a decrease in frequency of saquinavir dosing to twice daily. In this study, we evaluated the safety and pharmacokinetics of combining once-daily doses of the soft-gel capsule (SGC) formulation of saquinavir (saquinavir-SGC) and minidose ritonavir. Forty-four healthy HIV-negative volunteers were randomized into groups receiving once-daily doses of saquinavir-SGC (1,200 to 1,800 mg) plus ritonavir (100 to 200 mg) or a control group receiving only saquinavir-SGC (1,200 mg) three times daily. Saquinavir-SGC alone and saquinavir-SGC–ritonavir combinations were generally well tolerated, and there were no safety concerns. Addition of ritonavir (100 mg) to saquinavir-SGC (1,200 to 1,800 mg/day) increased the area under the concentration-time curve (AUC) for saquinavir severalfold, and the intersubject peak concentration in plasma and AUC variability were reduced compared to those achieved with saquinavir-SGC alone (3,600 mg/day), while trough saquinavir levels (24 h post-dose) were substantially higher than the 90% inhibitory concentration calculated from HIV-1 clinical isolates. Neither increasing the saquinavir-SGC dose to higher than 1,600 mg nor increasing ritonavir from 100 to 200 mg appeared to further enhance the AUC. These results suggest that an all once-daily HAART regimen, utilizing saquinavir-SGC plus a more tolerable low dose of ritonavir, may be feasible. Studies of once-daily saquinavir-SGC (1,600 mg) in combination with ritonavir (100 mg) in HIV-infected patients are underway.
New NRZ-mode resonant tunneling bistable-to-monostable-to-bistable transition logic element operating up to 36 Gb/s

In this paper, we present new resonant tunneling bistable-to-monostable-to-bistable transition logic element with non-return-to-zero (NRZ) mode output. The proposed circuit is composed of resonant tunneling diode (RTD)/high electron mobility transistor (HEMT) series connection (RHS) and RTD/HEMT parallel connection (RHP). Novel high-speed and low-power NRZ delayed flip-flop (D-F/F) operation has been successfully achieved using RTD/HEMT integration technology on an InP substrate. The operation of the fabricated circuit was confirmed up to 36 Gb/s with a very low power dissipation of about 3 mW at a power supply voltage of 0.9 V.
Exchange, Value and Affect: Bourdieu and ‘The Self’

A meeting ground for mainstream social theory and contemporary feminist theory. Brings feminist theory face to face with Pierre Bourdieu s social theory. Demonstrates how much Bourdieu s theory has to offer to contemporary feminism. Comprises a series of contributions from key contemporary feminist thinkers. Defines new territories for feminist theorizing. Transforms and advances Bourdieu s social and cultural theory.
Beyond disabilities: broadening the view of special needs and the inclusive education challenges facing primary teachers

Previous research on teacher attitudes and responses to inclusion has focused predominantly on the pedagogical challenges posed by students with disabilities in regular classrooms. The special education literature has been slow to recognise the significance of the impact of student diversity on the work of teachers and the reality that classrooms are populated with children who, while they may not have a recognised disability, nevertheless have a wide variety of special educational needs. This paper reports the findings of a study of the relative inclusive education challenges posed to primary teachers of a diverse group of students. Teachers were presented with 14 case descriptions of students in the form of vignettes. The students depicted where characterised has having special needs associated with such factors as disability, cultural background, dysfunctional family background, emotional/psychiatric condition, socio-economic disadvantage, mobility, homelessness etc. The teachers were asked to rate the students depicted in the vignettes on the level of difficulty they would have in providing an inclusive education for them and to identify what specific characteristics or attributes of the students they would find most challenging. This paper reports the findings of this survey and discusses the implications of the findings for both pre-service and in-service professional development
Learning from "Shadow Security": Why understanding non-compliant behaviors provides the basis for effective security

Over the past decade, security researchers and practitioners have tried to understand why employees do not comply with organizational security policies and mechanisms. Past re-search has treated compliance as a binary decision: people comply, or they do not. From our analysis of 118 in-depth interviews with individuals (employees in a large multinational organization) about security non-compliance, a 3rd response emerges: shadow security. This describes the instances where security-conscious employees who think they cannot comply with the prescribed security policy create a more fitting alter-native to the policies and mechanisms created by the organization’s official security staff. These workarounds are usually not visible to official security and higher management – hence ‘shadow security’. They may not be as secure as the ‘official’ policy would be in theory, but they reflect the best compromise staff can find between getting the job done and managing the risks that the assets they understand face. We conclude that rather than trying to ‘stamp out’ shadow security practices, organizations should learn from them: they provide a starting point ‘workable’ security: solutions that offer effective security and fit with the organization’s business, rather than impede it.
Conjunctive Choice Logic

Handling preferences in presence of constraints is an important concept in many applications. The main purpose of this paper is to provide a new non-classical logic for representing and reasoning with preferences and functional constraints in uncertain environments. This logic, called Conjunctive Choice Logic (CCL), aims to determine feasible solutions in such environments and evaluate their satisfaction degrees. Our logic extends the propositional logic with a new logical connective called ordered conjunction. This operator, viewed as a kind of prioritized conjunction, is used when there are preferences and constraints between pieces of information.
Measuring patient changes in mood, anxiety, and personality disorders : toward a core battery

Overview and Summary of the Core Battery Conference Dimensions of Outcome Measurement Some Implications of Priming Methodologies for Measures of Change Following Psychological and Pharmacological Interventions Measuring Treatment Outcome for Posttraumatic Stress Disorder and Social Phobia - A Review of Current Instruments and Recommendations for Future Research Measuring Change in Patients following Psychological and Pharmacological Interventions - Anxiety Disorders Measuring Progress and Outcome in the Treatment of Affective Disorders Measuring Change in Depression after Psychotherapy - Criteria for Core Batteries Using Empirical Research Findings to Develop a Behavioural Measure of Depression - A Proposed Direction for Future Research Measurement Issues Relevant to Personality Disorders Outcomes Evaluation of Psychosocial Treatment for Personality Disorders - Functions, Obstacles, Goals, and Strategies.