Miracle-dz/UniFAR-FTUs huggingface dataset:
Treatment of Peritoneal Carcinomatosis by Targeted Delivery of the Radio-Labeled Tumor Homing Peptide 213Bi-DTPA-[F3]2 into the Nucleus of Tumor Cells

Background α-particle emitting isotopes are effective novel tools in cancer therapy, but targeted delivery into tumors is a prerequisite of their application to avoid toxic side effects. Peritoneal carcinomatosis is a widespread dissemination of tumors throughout the peritoneal cavity. As peritoneal carcinomatosis is fatal in most cases, novel therapies are needed. F3 is a tumor homing peptide which is internalized into the nucleus of tumor cells upon binding to nucleolin on the cell surface. Therefore, F3 may be an appropriate carrier for α-particle emitting isotopes facilitating selective tumor therapies. Principal Findings A dimer of the vascular tumor homing peptide F3 was chemically coupled to the α-emitter 213Bi (213Bi-DTPA-[F3]2). We found 213Bi-DTPA-[F3]2 to accumulate in the nucleus of tumor cells in vitro and in intraperitoneally growing tumors in vivo. To study the anti-tumor activity of 213Bi-DTPA-[F3]2 we treated mice bearing intraperitoneally growing xenograft tumors with 213Bi-DTPA-[F3]2. In a tumor prevention study between the days 4–14 after inoculation of tumor cells 6×1.85 MBq (50 µCi) of 213Bi-DTPA-[F3]2 were injected. In a tumor reduction study between the days 16–26 after inoculation of tumor cells 6×1.85 MBq of 213Bi-DTPA-[F3]2 were injected. The survival time of the animals was increased from 51 to 93.5 days in the prevention study and from 57 days to 78 days in the tumor reduction study. No toxicity of the treatment was observed. In bio-distribution studies we found 213Bi-DTPA-[F3]2 to accumulate in tumors but only low activities were found in control organs except for the kidneys, where 213Bi-DTPA-[F3]2 is found due to renal excretion. Conclusions/Significance In conclusion we report that 213Bi-DTPA-[F3]2 is a novel tool for the targeted delivery of α-emitters into the nucleus of tumor cells that effectively controls peritoneal carcinomatosis in preclinical models and may also be useful in oncology.
Correlation between Autism Treatment Evaluation Checklist (ATEC) and Childhood Autism Rating Scale (CARS) in the evaluation of autism spectrum disorder.

Identification of health issues in children with autism spectrum disorder (ASD) is paramount to provide appropriate care and interventions. The Autism Treatment Evaluation Checklist (ATEC) is the one of the few current measures that assesses ASD-associated health problems thus informing intervention decisions. However, little research has been conducted to compare ATEC with other more recognized measures such as the Childhood Autism Rating Scale (CARS). It is unclear whether these two scales can be used interchangeably or whether high scores on one scale are comparable to the other. The aim of the current study was to compare the correlation between ATEC and CARS in the evaluation of children with ASD. This prospective cross-sectional study was conducted at the Developmental and Behavioural Paediatrics Outpatient Clinic at King Saud University, King Khalid University hospital (KKUH) in Riyadh, Saudi Arabia. Forty children with a prior diagnosis of ASD seen during the period from October 2014 to August 2015 were included. Each child was assessed using ATEC and CARS independently during the same visit. The Spearman's rank correlation coefficient test was used. The overall mean CARS score was 34.125 ± 5.535 (range from 22 to 42) and the mean ATEC score was 40.95± 9.1934. 1 (range from 24 to 72). The Spearman's rank correlation coefficient (rs) was 0.015, and p-value was 0.926 (> 0.05) meaning that there was no correlation between CARS and ATEC scales. No correlation between CARS and ATEC scale was found. ATEC should not be used instead of CARS to delineate co-morbid health issues. Future studies are needed to assess the validity of ATEC and its correlation with other well established scales.
How public key cryptography influences wireless sensor node lifetime

In this paper we try to estimate the real influence of public key cryptography (PKC) to the lifetime of a sensor node in wireless sensor networks. We investigate four types of nodes; MICA2DOT, MICA2, MICAz and TelosB. For all these nodes we estimate the power consumption for most common RSA and ECC operations, i.e., signature generation and verification as well as key exchange mechanisms. We also estimate the power consumed by the transmission of their results. Our results show that the application of strong cryptography is feasible. Even for the most constrained node performing the ECC-160 signature once every 10 minutes increases the duty cycle only by about 0.5 per cent, i.e., the influence to the lifetime is not significant. Nevertheless, the public key cryptography shall be used with care.
Neuronal Early Endosomes Require EHD1 for L1/NgCAM Trafficking

In neurons, the endosomal system is essential for membrane receptor trafficking to dendrites and axons and thereby participates in various neuronal functions, such as neurite outgrowth and synaptic plasticity. A multitude of regulators coordinates trafficking through endosomes, but most of them have not been studied in detail in neurons. In non-neuronal cells, EHD1 (Eps15 homology-domain containing protein 1) functions in the recycling endosome and is required for endosome-to-plasma membrane transport of multiple cargos. In this study, we analyze the role of EHD1 in neurons. In particular, we investigate whether EHD1 is required for polarized trafficking of the dendritically targeted transferrin and the axonal adhesion molecule L1/NgCAM (neuron–glia cell adhesion molecule) and, if so, in what compartment it is required. We find that endosomal recycling of both L1/NgCAM and transferrin is impaired when EHD1 is downregulated. We show that EHD1 colocalizes with L1/NgCAM and transferrin mostly in EEA1 (early endosome antigen 1)-positive early endosomes and less extensively with recycling endosomes. Using live imaging, we observe that EHD1 is stably associated with endosomal membranes during their maturation into EEA1-positive compartments and often persists on them longer than EEA1. Finally, we show that downregulation of EHD1 causes a delay of L1/NgCAM in exiting EEA1-positive endosomes, resulting in impaired targeting of L1/NgCAM to the axonal membrane. We conclude that, in neurons, EHD1 functions in early endosomes rather than (or possibly in addition to) recycling endosomes. These findings point to the existence of neuronal adaptations of the endosomal system.
Face Recognition using Optimal Representation Ensemble

Recently, the face recognizers based on linear representations have been shown to deliver state-of-the-art performance. These approaches assume that the faces, belonging to one individual, reside in a linear-subspace with a respectively low dimensionality. In real-world applications, however, face images usually suffer from expressions, disguises and random occlusions. The problematic facial parts undermine the validity of the subspace assumption and thus the recognition performance deteriorates significantly. In this work, we address the problem in a learning-inference-mixed fashion. By observing that the linear-subspace assumption is more reliable on certain face patches rather than on the holistic face, some Bayesian Patch Representations (BPRs) are randomly generated and interpreted according to the Bayes’ theory. We then train an ensemble model over the patchrepresentations by minimizing the empirical risk w.r. t. the “leave-one-out margins”. The obtained model is termed Optimal Representation Ensemble (ORE), since it guarantees the optimality from the perspective of Empirical Risk Minimization. To handle the unknown patterns in test faces, a robust version of BPR is proposed by taking the non-face category into consideration. Equipped with the Robust-BPRs, the inference ability of ORE is increased dramatically and several record-breaking accuracies (99:9% on Yale-B and 99:5% on AR) and desirable efficiencies (below 20 ms per face in Matlab) are achieved. It also overwhelms other modular heuristics on the faces with random occlusions, extreme expressions and disguises. Furthermore, to accommodate immense BPRs sets, a boosting-like algorithm is also derived. The boosted model, a.k. a. Boosted-ORE, obtains similar performance to its prototype. Besides the empirical superiorities, two desirable features of the proposed methods, namely, the training-determined model-selection and the data-weight-free boosting procedure, are also theoretically verified. They reduce the training complexity immensely, while keeps the generalization capacity not changed.
Reward‐Related Responses in the Human Striatum

Abstract: Much of our knowledge of how reward information is processed in the brain comes from a rich animal literature. Recently, the advancement of neuroimaging techniques has allowed researchers to extend such investigations to the human brain. A common finding across species and methodologies is the involvement of the striatum, the input structure of the basal ganglia, in a circuit responsible for mediating goal‐directed behavior. Central to this idea is the role of the striatum in the processing of affective stimuli, such as rewards and punishments. The goal of this article is to probe the human reward circuit, specifically the striatum and its subdivisions, with an emphasis on how the affective properties of outcomes or feedback influence the underlying neural activity and subsequent decision making. Discussion will first focus on anatomical and functional considerations regarding the striatum that have emerged from animal models. The rest of the article will center on how human neuroimaging studies map to findings from the animal literature, and how more recently, this research can be extended into the social and economic domains.
The spectrum of Poincaré recurrence

Abstract We investigate the relationship between Poincaré recurrence and topological entropy of a dynamical system (X,f). For $0 \leq \alpha \leq \beta \leq \infty $, let D(α,β) be the set of x with lower and upper recurrence rates α and β, respectively. Under the assumptions that the system is not minimal and that the map f is positively expansive and satisfies the specification condition, we show that for any open subset $\emptyset \neq U \subseteq X$, $D(\alpha , \beta ) \cap U$ has the full topological entropy of X. This extends a result of Feng and Wu [The Hausdorff dimension of recurrence sets in symbolic spaces. Nonlinearity 14 (2001), 81–85] for symbolic spaces.
Late Complications of Clinical Clostridium Histolyticum Collagenase Use in Dupuytren's Disease

Introduction While Dupuytren's disease can cause disabling contractures requiring open surgery, a less-invasive option using Clostridium Histolyticum collagenase (CHC) via percutaneous injection was recently reported. A recent prospective, randomized trial demonstrated few complications during 90 days follow-up, however did not assess any longer term follow-up for these patients. Long-term outcomes in this setting have not been adequately reported, and the current manuscript aims to identify late complications from the clinical use of percutaneous CHC. Methods The current manuscript reports an extended 12-month follow-up for a cohort of twelve of patients enrolled in the original prospective, randomized trial, treated at a single institution. An analysis of complications requiring surgical intervention was undertaken. Results Two of twelve patients reported debilitating pain and triggering requiring surgical intervention. Extensive deep-tissue scarring and adhesions were identified, providing the first visual and qualitative analysis of the pathologic effects of CHC. Conclusion Late complications from CHC use can and have occurred, outside the follow-up period of the initial phase III trials. Longer term follow-up of such patients is thus essential, and further investigation and characterization of the late effects of CHC use is warranted.
A typical problem gambler affects six others

Abstract While the financial and psychological burden on problem gamblers can be severe, at least some of the ill effects are also passed on to family or other close social ties. The present study estimated the number of affected-others for the typical problem gambler. Australian members of an online panel with gambling problems (N = 3076) and panel members who indicated that they had been affected by someone else’s gambling (N = 2129) were asked to estimate the number of other people who were negatively affected by their gambling. Using robust statistics to analyse this data, the study found lower estimates made by problem gamblers (four affected people) compared to estimates made by affected others (six affected people, including the respondent). It was concluded that a point-estimate of six people affected is a more accurate figure since it does not suffer from self-presentation effects of problem gamblers. Low-risk and moderate-risk gamblers, unsurprisingly, affected far fewer other people (one and three, respectively). Both gamblers and affected-others most often identified close family members, including spouses and children, as the people impacted by others’ gambling problems. These results provide an approximate measure of the number of people affected, per problem gambler, to facilitate accurate accounting of the harms accruing from gambling problems.
Athlete and coach agreement: Identifying successful performance

Traditional coaching views the coach as an informed resource and the athlete as a reflection of expert knowledge. Recent approaches have criticised a strictly coach driven model of expertise, and in doing so have acknowledged the unique and developing knowledge of athletes, which emerges from extended practice. The growth of the athlete’s contribution in the coach–athlete dyad invites interesting questions about the usefulness of athlete knowledge and the changing role of the coach. Athlete–coach agreement was assessed via a triangulation of quantitative boat speed data from a single sculler and matched to phases of successful rowing that rowers and coaches both agreed on. Coach and rower were able to identify when the boat was travelling its fastest or slowest. However, when the performance was marginally faster or slower, they disagreed, and generally the rowers were more accurate about the performance than their coach. Implications for contemporary coaching practices are considered.
GDNF secreted from adipose-derived stem cells stimulates VEGF-independent angiogenesis

Adipose tissue stroma contains a population of mesenchymal stem cells (MSC) promote new blood vessel formation and stabilization. These adipose-derived stem cells (ASC) promote de novo formation of vascular structures in vitro. We investigated the angiogenic factors secreted by ASC and discovered that glial-derived neurotrophic factor (GDNF) is a key mediator for endothelial cell network formation. It was found that both GDNF alone or present in ASC-conditioned medium (ASC-CM) stimulated capillary network formation by using human umbilical vein endothelial cells (HUVECs) and such an effect was totally independent of vascular endothelial growth factor (VEGF) activity. Additionally, we showed stimulation of capillary network formation by GDNF, but not VEGF, could be blocked by the Ret (rearranged during transfection) receptor antagonist RPI-1, a GDNF signaling inhibitor. Furthermore, GDNF were found to be overexpressed in cancer cells that were resistant to the anti-angiogenic treatment using the VEGF antibody. Cancer cells in the liver hepatocellular carcinoma (HCC), a non-nervous related cancer, highly overexpressed GDNF as compared to normal liver cells. Our data strongly suggest that, in addition to VEGF, GDNF secreted by ASC and HCC cells, may be another important factor promoting pathological neovascularization. Thus, GDNF may be a potential therapeutic target for HCC and obesity treatments.
Pure States, Mixed States and Hawking Problem in Generalized Quantum Mechanics

This paper is the continuation of a study into the information paradox problem started by the author in his earlier works. As before, the key instrument is a deformed density matrix in quantum mechanics of the early universe. It is assumed that the latter represents quantum mechanics with fundamental length. It is demonstrated that the obtained results agree well with the canonical viewpoint that in the processes involving black holes pure states go to the mixed ones in the assumption that all measurements are performed by the observer in a well-known quantum mechanics. Also it is shown that high entropy for Planck's remnants of black holes appearing in the assumption of the generalized uncertainty relations may be explained within the scope of the density matrix entropy introduced by the author previously. It is noted that the suggested paradigm is consistent with the holographic principle. Because of this, a conjecture is made about the possibility for obtaining the generalized uncertainty relations fro.
Susceptibility to smoking among South East Asian youth: a multilevel analysis

Objective: To estimate the extent to which susceptibility to smoking is associated with between-context differences (schools and classes) and to identify factors at school, class and individual levels that influence individual susceptibility to smoking among young never-smokers in South East Asia. Methods: Cross-sectional data from the Global Youth Tobacco Survey conducted in Cambodia (2002), Laos (2003) and Vietnam (2003) are used to conduct multilevel analyses that account for the nesting of students in classes and classes in schools. The outcome variable is smoking susceptibility, defined as the absence of a firm decision not to smoke. Explanatory variables include school-level (current tobacco use prevalence in school, exposure to anti-smoking media messages and exposure to tobacco billboard advertising), class-level (classroom prevention) and individual-level influences (parents’ and friends’ smoking behaviour, knowledge of the harmful effects of and exposure to secondhand smoke at home, age, sex and pocket income). Results: Multilevel analyses indicate that 4.5 and 4.2 of the variation in smoking susceptibility is associated with school and class differences, respectively. Students who have parents or friends who smoke, who are exposed to secondhand smoke at home and those who have access to pocket income are found to be more susceptible while greater knowledge of the harmful effects of secondhand smoke appears to diminish susceptibility to smoking. For girls only, billboard tobacco advertising increases the risk of susceptibility and classroom prevention decreases risk while for boys only, attendance at schools with higher prevalence of tobacco use increases risk of susceptibility and anti-smoking media messages decreases risk. Conclusions: This study highlights a number of modifiable factors associated with smoking susceptibility and identifies interactions between teen sex and several factors associated with the susceptibility to smoking. This finding provides support for the call to move beyond gender-blind tobacco control policies.
The Importance of Timing in Reciprocity: An Investigation of Reciprocity Norms Among Indians and Americans

After receiving help, individuals tend to experience an immediate increase in obligation to be responsive to the helper. Cross-cultural research has shown that whereas this sense of obligation dissipates for Americans after reciprocation, it remains unchanged after reciprocation for Indians. Is this decrease in obligation felt by Americans temporary, or can it endure over years such that it provides immunity from responding to the helper? And is there a statute of limitations on the experience of obligation for Indians? If individuals do not reciprocate, can obligation expire? We addressed these questions in a vignette-based experimental investigation involving American and Indian adults. Study 1 (N = 153) demonstrated that Americans but not Indians felt less obligation to aid the helper after reciprocation than in situations in which they had not reciprocated years after receiving a benefit. Reciprocation thus provided Americans, but not Indians, with immunity from being responsive to the helper. Study 2 (N = 141) demonstrated that Americans but not Indians felt less obligation years after as compared with months after receiving a benefit. The passage of time thus expired obligation to be responsive to the helper for Americans but not for Indians. Study 3 (N = 129) provided ecological validity to our hypotheses by assessing real-life friendships, showing how both reciprocations and time passage affect obligation independently and in combination. The findings imply that prosocial behavior is affected by both time passage and reciprocation among Americans but not Indians.
Peningkatan Motivasi dan Kemampuan Menulis Puisi Melalui Teknik Timlo Aplikasi Copy The Master Peserta Didik Kelas VIII A SMP N 3 Sragi Kabupaten Pekalongan

This researcher was motivated to conduct this study because of the less ability of the leaener to write poetry. It coud be seen from the average score of the pretest of poetry writing which only reached 73. The purpose of the study was to improve motivation and the learning result of poetry writing in the students of VIIIA of SMPN 3 Sragi, Pekalongan by applying Timlo aplication of Copy the Master Technique. The method used in this Class Action Research was using two cycles. The subjects were 32 students of class VIII A. The result showed that there was a significant improvement in learning the technique of poetry wriring. The average score of pretest was 73. After the applying Timlo technique, the average score of the cycle I was 79.88 and it increased in the cycle II to 84.00. The increasing score from the pretest to the first cycle was 68.8%. Meanwhile, the increasing score from cycle I to cycle II was 41.2%. In addition, there was an increasing motivation of the students for learning to poetry writing. Thus, it was suggested for Indonesian subject's teacher for using this model in teching and learning process.
Delaying the Mitochondrial Decay of Aging with Acetylcarnitine

Abstract: Oxidative mitochondrial decay is a major contributor to aging. Some of this decay can be reversed in old rats by feeding them normal mitochondrial metabolites, acetylcarnitine (ALC) and lipoic acid (LA), at high levels. Feeding the substrate ALC with LA, a mitochondrial antioxidant, restores the velocity of the reaction (Km) for ALC transferase and mitochondrial function. The principle appears to be that, with age, increased oxidative damage to protein causes a deformation of structure of key enzymes with a consequent lessening of affinity (Km) for the enzyme substrate. The effect of age on the enzyme‐binding affinity can be mimicked by reacting it with malondialdehyde (a lipid peroxidation product that increases with age). In old rats (vs. young rats), mitochondrial membrane potential, cardiolipin level, respiratory control ratio, and cellular O2 uptake are lower; oxidants/O2, neuron RNA oxidation, and mutagenic aldehydes from lipid peroxidation are higher. Ambulatory activity and cognition decline with age. Feeding old rats ALC with LA for a few weeks restores mitochondrial function; lowers oxidants, neuron RNA oxidation, and mutagenic aldehydes; and increases rat ambulatory activity and cognition (as assayed with the Skinner box and Morris water maze). A recent meta‐analysis of 21 double‐blind clinical trials of ALC in the treatment of mild cognitive impairment and mild Alzheimer's disease showed significant efficacy vs. placebo. A meta‐analysis of 4 clinical trials of LA for treatment of neuropathic deficits in diabetes showed significant efficacy vs. placebo.