Miracle-dz/UniFAR-FTUs huggingface dataset:
Oxygen Effect on Magnetic Anisotropy Energy of Co Nanowires on Cu(210) Surface - An Ab Initio Study

An ab initio study of Co monatomic nanowires (NW) magnetic properties on pure and oxygen reconstructed Cu (210) surface was performed. Strong influence of oxygen surface impurity on MAE in Co nanowire was found. High value of magnetic moment and small energy of magnetic anisotropy (MAE) were obtained in Co nanowires on pure Cu (210) surface. After oxygen reconstruction of Cu (210) surface (Cu (210)-(2×1)O) the significant enhancement of MAE was found in Co nanowires, while the magnetic moment of Co atoms is practically unchanged. Oxygen on Cu (210) surface rotates easy magnetization axis in Co NW with respect to the pure surface.
A genetic CLOCK variant associated with cluster headache causing increased mRNA levels

Background Cluster headache is characterized by recurrent unilateral headache attacks of severe intensity. One of the main features in a majority of patients is a striking rhythmicity of attacks. The CLOCK (Circadian Locomotor Output Cycles Kaput) gene encodes a transcription factor that serves as a basic driving force for circadian rhythm in humans and is therefore particularly interesting as a candidate gene for cluster headache. Methods We performed an association study on a large Swedish cluster headache case-control sample (449 patients and 677 controls) screening for three single nucleotide polymorphisms (SNPs) in the CLOCK gene implicated in diurnal preference (rs1801260) or sleep duration (rs11932595 and rs12649507), respectively. We further wanted to investigate the effect of identified associated SNPs on CLOCK gene expression. Results We found a significant association with rs12649507 and cluster headache (p = 0.0069) and this data was strengthened when stratifying for reported diurnal rhythmicity of attacks (p = 0.0009). We investigated the effect of rs12649507 on CLOCK gene expression in human primary fibroblast cultures and identified a significant increase in CLOCK mRNA expression (p = 0.0232). Conclusions Our results strengthen the hypothesis of the involvement of circadian rhythm in cluster headache.
Towards Spatial Reasoning with Strings and Pins

Spatial problems and a variety of abstract problems can be solved by humans with more ease if the problem can be visualized and/or manipulated. Elaborating on the differences and interplay between representing spatial problems and solving them, this paper focuses on exploring the qualities of a strings and pins problem solving domain. This domain is compared to the straightedge and compass domain of Euclidean geometry. The strings and pins domain is described and two case studies are analyzed: (i) a strings and pins solution of the shortest path problem and (ii) a strings and pins solution to the Voronoi diagram problem; both approaches are compared to a formal solution. Differences and similarities between the straightedge and compass domain and the strings and pins domain are analyzed, and features and limitations of constructive and depictive geometry are discussed. Different problem solving phases are distinguished. Furthermore, cognitive aspects of different problem solving approaches are discussed.
Renin–angiotensin system gene expression and neurodegenerative diseases

Hypothesis: Single nucleotide polymorphisms and altered gene expression of components of the renin–angiotensin system (RAS) are associated with neurodegenerative diseases. Introduction: Drugs that interact with the RAS have been shown to affect the course of neurodegenerative disease, suggesting that abnormalities in the RAS may contribute to neurodegenerative disease. Materials and methods: A meta-analysis of genome-wide association studies and gene expression data for 14 RAS-related proteins was carried out for five neurodegenerative diseases: Alzheimer’s disease, Parkinson’s disease, narcolepsy, amyotrophic lateral sclerosis and multiple sclerosis. Results: No single nucleotide polymorphisms in any of the 14 RAS-related protein genes were significantly associated with the five neurodegenerative diseases investigated. There was an inverse association between expression of ATP6AP2, which encodes the (pro)renin receptor, and multiple sclerosis, Alzheimer’s disease and Parkinson’s disease. An association of AGTR, which encodes the AT1 angiotensin II receptor, and Parkinson’s disease and Alzheimer’s disease was also observed. Conclusions: To date, no single nucleotide polymorphisms in components of the RAS can be definitively linked to the neurodegenerative diseases evaluated in this study. However, altered gene expression of several components of the RAS is associated with several neurodegenerative diseases, which may indicate that the RAS contributes to the pathology of these diseases.
SRC Increases MYC mRNA Expression in Estrogen Receptor-Positive Breast Cancer via mRNA Stabilization and Inhibition of p53 Function

ABSTRACT The transcription factor gene MYC is important in breast cancer, and its mRNA is maintained at a high level even in the absence of gene amplification. The mechanism(s) underlying increased MYC mRNA expression is unknown. Here, we demonstrate that MYC mRNA was stabilized upon estrogen stimulation of estrogen receptor-positive breast cancer cells via SRC-dependent effects on a recently described RNA-binding protein, IMP1 with an N-terminal deletion (ΔN-IMP1). We also show that loss of the tumor suppressor p53 increased MYC mRNA levels even in the absence of estrogen stimulation. However, in cells with wild-type p53, SRC acted to overcome p53-mediated inhibition of estrogen-stimulated cell cycle entry and progression. SRC thus promotes cell proliferation in two ways: by stabilizing MYC mRNA and by inhibiting p53 function. Since estrogen receptor-positive breast cancers typically express wild-type p53, these studies establish a rationale for p53 status to be predictive for effective SRC inhibitor treatment in this subtype of breast cancer.
Alloy Design and Microstructure of Advanced Permanent Magnets Using Rapid Solidification and Powder Processing

Current Nd 2 Fe 14 B magnet alloys exhibit excellent room-temperature magnetic properties and they are well suited for applications with operating temperatures ≤ 120°C, due in part to their low Curie temperature of ∼310°C. The poor temperature stability of these rare earth (RE) permanent magnet alloys above 120°C limits their current performance in existing motors and their potential application in advanced drive-motor designs. Consequently, it is necessary to find other compositions to improve the thermal stability of RE 2 Fe 14 B magnets. A systematic study was conducted by melt spinning on the magnetic properties of a series of isotropic nanocrystalline magnet alloys where a yttrium (Y)+dysprosium (Dy) mixture replaced neodymium (Nd) or praseodymium (Pr) as the dominant RE constituent in mixed rare earth (MRE) 2 Fe 14 B (MRE = Y+Dy+Nd). The most recent results have shown that the Y+Dy-based MRE 2 Fe 14 B alloy can result in isotropic bonded magnets with superior magnetic properties in competitive commercial isotropic bonded magnets above ∼30°C and well beyond 200°C by a judicious combination of Y, Dy, and Nd, along with a minor cobalt substitution for iron. Gasatomized powders of these advanced magnet alloys have also demonstrated improved magnetic strength over existing commercial spherical powders in a fine-powder-size range that is suitable for injection molding of bonded isotropic magnets.
Protein Storage Vacuoles Originate from Remodeled Preexisting Vacuoles in Arabidopsis thaliana1[OPEN]

Preexisting vacuoles are reprogrammed to give rise to protein storage vacuoles. Protein storage vacuoles (PSV) are the main repository of protein in dicotyledonous seeds, but little is known about the origins of these transient organelles. PSV are hypothesized to either arise de novo or originate from the preexisting embryonic vacuole (EV) during seed maturation. Here, we tested these hypotheses by studying PSV formation in Arabidopsis (Arabidopsis thaliana) embryos at different stages of seed maturation and recapitulated this process in Arabidopsis leaves reprogrammed to an embryogenic fate by inducing expression of the LEAFY COTYLEDON2 transcription factor. Confocal and immunoelectron microscopy indicated that both storage proteins and tonoplast proteins typical of PSV were delivered to the preexisting EV in embryos or to the lytic vacuole in reprogrammed leaf cells. In addition, sectioning through embryos at several developmental stages using serial block face scanning electron microscopy revealed the 3D architecture of forming PSV. Our results indicate that the preexisting EV is reprogrammed to become a PSV in Arabidopsis.
Innovation Providing New Multiple Functions in Phase-Change Materials To Achieve Cognitive Computing

This paper describes a basic new scientific and technological approach for information and computing use. It is based on Ovonic cognitive devices that utilize an atomically engineered Ovonic chalcogenide material as the active medium. We demonstrate how such a device possesses many unique functions including an intrinsic neurosynaptic functionality that permits the processing of information in a manner analogous to that of biological neurons and synapses. Our Ovonic cognitive devices can not only accomplish conventional binary computing, but are capable of non-binary generation of information, storage, encryption, higher mathematics, modular arithmetic and factoring. Uniquely, almost all of these functions can be accomplished in a single nanosized device. These devices and systems are robust at room temperature (and above). They are non-volatile and also can include other volatile devices such as the Ovonic Threshold Switch and Ovonic multi-terminal threshold and memory devices that can replace transistors.
Food Insecurity, Food “Deserts,” and Glycemic Control in Patients With Diabetes: A Longitudinal Analysis

OBJECTIVE Both food insecurity (limited food access owing to cost) and living in areas with low physical access to nutritious foods are public health concerns, but their relative contribution to diabetes management is poorly understood. RESEARCH DESIGN AND METHODS This was a prospective cohort study. A random sample of patients with diabetes in a primary care network completed food insecurity assessment in 2013. Low physical food access at the census tract level was defined as no supermarket within 1 mile in urban areas and 10 miles in rural areas. HbA1c measurements were obtained from electronic health records through November 2016. The relationship among food insecurity, low physical food access, and glycemic control (as defined by HbA1c) was analyzed using hierarchical linear mixed models. RESULTS Three hundred and ninety-one participants were followed for a mean of 37 months. Twenty percent of respondents reported food insecurity, and 31% resided in an area of low physical food access. In adjusted models, food insecurity was associated with higher HbA1c (difference of 0.6% [6.6 mmol/mol], 95% CI 0.4–0.8 [4.4–8.7], P < 0.0001), which did not improve over time (P = 0.50). Living in an area with low physical food access was not associated with a difference in HbA1c (difference 0.2% [2.2 mmol/mol], 95% CI −0.2 to 0.5 [−2.2 to 5.6], P = 0.33) or with change over time (P = 0.07). CONCLUSIONS Food insecurity is associated with higher HbA1c, but living in an area with low physical food access is not. Food insecurity screening and interventions may help improve glycemic control for vulnerable patients.
Temporal Variations in Metabolic and Autotrophic Indices for Acropora digitifera and Acropora spicifera – Implications for Monitoring Projects

Coral health indices are important components of the management assessments of coral reefs, providing insight into local variation in reef condition, as well as tools for comparisons between reefs and across various time scales. Understanding how such health indices vary in space and time is critical to their successful implementation as management tools. Here we compare autotrophic and heterotrophic coral health indices, examining specifically the temporal variation driven by the local environmental variation, at three scales (diel, daily and seasonal). We compared metabolic indices (RNA/DNA ratio, protein concentration) and autotrophic indices (Chlorophyll a (Chl a), zooxanthellae density, effective quantum yield (yield) and relative electron transport rate (rETR)) for two dominant Acropora species, A. digitifera and A. spicifera at Ningaloo Reef (north-western Australia) in August 2010 (austral winter) and February 2011 (austral summer). Clear seasonal patterns were documented for metabolic indices, zooxanthellae density and rETR, while cyclic diel patterns only occurred for yield and rETR, and RNA/DNA ratio. Significant daily variation was observed for RNA/DNA ratio, Chl a concentration, yield and rETR. Results suggest that zooxanthellae density and protein concentrations are good long-term indicators of coral health whose variance is largely seasonal, while RNA/DNA ratio and rETR can be used for both long-term (seasonal) and short-term (diel) coral monitoring. Chl a can be used to describe changes between days and yield for both diel and daily variations. Correlations between health indices and light history showed that short-term changes in irradiance had the strongest impact on all health indices except zooxanthellae density for A. digitifera; for A. spicifera no correlation was observed at all. However, cumulative irradiance over the several days before sampling showed significant correlations with most health indices suggesting that a time-lag effect has to be taken into account when interpreting diel variations in coral condition.
Simulating soil organic carbon in yedoma deposits during the Last Glacial Maximum in a land surface model

Substantial quantities of organic carbon (OC) are stored in the thick, ice‐rich, and organic‐rich sediments called yedoma deposits, distributed in eastern Siberia and Alaska today. Quantifying yedoma carbon stocks during the glacial period is important for understanding how much carbon could have been decomposed during the last deglaciation. Yet processes that yield the formation of thick frozen OC in yedoma deposits are missing in global carbon cycle models. Here we incorporate sedimentation parameterizations into the Organizing Carbon and Hydrology In Dynamic Ecosystems (ORCHIDEE‐MICT) land surface model, which leads to reasonable results in OC vertical distribution and regional budgets, compared with site‐specific observations and inventories for today's nondegraded yedoma region. Simulated total soil OC stock for the northern permafrost region during the Last Glacial Maximum (LGM) is 1536–1592 Pg C, of which 390–446 Pg C is within today's yedoma region. This result is an underestimation since we did not account for the potentially much larger yedoma area during the LGM than the present day.
Associations between physical function, dual-task performance and cognition in patients with mild Alzheimer's disease

Objective: Alzheimer's disease (AD) causes a gradual decline in cognition, limitations of dual-tasking and physical function leading to total dependence. Hence, information about the interaction between physical function, dual-task performance and cognition may lead to new treatment strategies with the purpose of preserving function and quality of life. The objective of this study was to investigate the associations between physical function, dual-task performance and cognition in community-dwelling patients with mild AD. Methods: Baseline results from 185 participants (50–90 years old) in the single blinded multicenter RCT ‘ADEX’ (Alzheimer's disease: the effect of physical exercise) were used. Assessments included tests of physical function: 400-m walk test, 10-m walk test, Timed Up and Go test and 30-s chair stand test; dual-task performance, i.e., 10-m walk while counting backwards from 50 or naming the months backwards; and cognition, i.e., Mini Mental State Examination, Symbol Digit Modalities Test, the Stroop Color and Word Test, and Lexical verbal fluency test. Results: Results in the 30-s chair stand test correlated significantly with all tests of cognition (r = .208–.242) while the other physical function tests only randomly correlated with tests of cognition. Results in the dual-task counting backwards correlated significantly with results in all tests of cognition (r = .259–.388), which accounted for 7%–15% of the variation indicating that a faster time to complete dual-task performance was associated with better cognitive performance. Conclusion: The evidence of the associations between physical function, dual-task performance and cognition is important when creating new rehabilitation interventions to patients with mild AD.
Classifying children with 3D depth cameras for enabling children's safety applications

In this work, we present ChildSafe, a classification system which exploits human skeletal features collected using a 3D depth camera to classify visual characteristics between children and adults. ChildSafe analyzes the histograms of training samples and implements a bin-boundary-based classifier. We train and evaluate ChildSafe using a large dataset of visual samples collected from 150 elementary school children and 43 adults, ranging in the ages of 7 and 50. Our results suggest that ChildSafe successfully detects children with a proper classification rate of up to 97%, a false negative rate of as low as 1.82%, and a low false positive rate of 1.46%. We envision this work as an effective sub-system for designing various child protection applications.
Anti-osteoporotic Effects of Unripe Fructus of Rubus coreanus Miquel in Osteoblastic and Osteoclastic Cells

Osteoporosis is a progressive bone disease characterized by low bone mass which is caused by disturbance in the balance between the activities of osteoblasts and osteoclasts. Postmenopausal osteoporosis is one of the most common disorders in women after menopause, which is linked to an estrogen deficiency and characterized by an excessive loss of trabecular bone. Rubus coreanus has been used for their various pharmacological properties in Asia as a traditional medicine. To investigate the effect of unripe fruits of R. coreanus 30% ethanol extract (RCE) on osteoblast-like cells (MG63) differentiation, we examined the effects of RCE on in vitro osteoblastic differentiation markers, alkaline phosphatase (ALP) activity and receptor activator of nuclear factor κ-B ligand (RANKL) and osteoprotegerin (OPG) expression. The high concentration (50 and 100 μg/mL) of RCE markedly increased ALP activity, whereas decreased the RANKL/OPG. We also investigated the effect of RCE on M-CSF plus RANKL-induced differentiation of pre-osteoclast cells (RAW 264.7). RCE treatment remarkably inhibited M-CSF/RANKL-induced formation of osteoclast-like multinuclear cells from RAW 264.7 cells. Moreover, the inhibitory effect of RCE was reduced by selective estrogen receptor-α antagonist. Our research suggests that suggested that unripe fruits of R. coreanus may act beneficial effects on bone mass by regulating both osteoblast and osteoclast.
Interdecadal Changes in the ENSO Teleconnection to the Caribbean Region and the North Atlantic Oscillation

Abstract The El Nino–Southern Oscillation (ENSO) phenomenon and variability in the subtropical North Atlantic high sea level pressure (SLP) are known to affect rainfall in the Caribbean region. An El Nino event is associated with drier-than-average conditions during the boreal summer of year (0), and wetter-than-average conditions during the spring of year (+1). Dry conditions during the summer of year (0) of an El Nino are associated with the locally divergent surface circulation engendered by the eastward shift of deep convection in the Pacific Ocean. Wet conditions during the spring of year (+1) of an El Nino are associated with the lagged warming of the tropical North Atlantic Ocean. Variability in the strength of the North Atlantic high is governed mainly by the North Atlantic oscillation (NAO) with a positive NAO phase implying a stronger than normal high and vice versa. The NAO is negatively correlated with Caribbean rainfall indirectly via anomalous sea surface temperatures (SST) associated with a.
Relevance of chronotype for eating patterns in adolescents

ABSTRACT During adolescence, a shift from morningness to eveningness occurs, yet school continues to start early in the morning. Hence, adolescents are at risk for social jetlag, i.e. a discrepancy between biological and social timing. It remains to be determined whether chronotype associates with daily and daytime-specific eating patterns during this potentially critical period. Therefore, the aim of the present study was to investigate whether chronotype is decisive for daily eating patterns [total energy intake (TEI, kcal), total macronutrient intake (% of TEI), eating occasion frequency (n/day), meal frequency (n/day), snack frequency (n/day), duration of nightly fasting], or daytime-specific eating patterns [morning (before 11 am) energy intake (% of TEI), morning macronutrient intake (% of morning energy intake), regular breakfast skipping (no morning energy intake at least on 2 of 3 days, yes/no), evening (after 6 pm) energy intake (% of TEI), evening macronutrient intake (% of evening energy intake), regular dinner skipping (no evening energy intake at least on 2 of 3 days, yes/no)] in German adolescents. Chronotype was assessed by use of the Munich Chronotype Questionnaire and is defined as the midpoint of sleep corrected for sleep-debt accumulated over the workweek (the later the midpoint of sleep, the later the chronotype). A total of 223 participants (10–18 years) provided 346 questionnaires and concurrent 3-day weighed dietary records. Associations between chronotype and eating patterns were analyzed cross-sectionally using multivariable linear and logistic mixed-effects regression models. Adolescents with earlier and later chronotypes did not differ in their daily eating patterns. With respect to daytime-specific eating patterns, 1 h delay in chronotype was associated with 4.0 (95% CI 2.5–6.6) greater odds of regular breakfast skipping (p < 0.0001). In addition, later chronotype was associated with higher evening energy intake (p = 0.0009). In conclusion, our data show that a later chronotype among adolescents is associated with a shift of food consumption toward later times of the day. Hence, adolescents’ eating patterns appear to follow their internal clock rather than socially determined schedules.