Miracle-dz/UniFAR-FTUs huggingface dataset:
Circulating microRNAs as Potential Biomarkers in Non-Alcoholic Fatty Liver Disease and Hepatocellular Carcinoma

Obesity and metabolic syndrome are growing epidemics worldwide and greatly responsible for many liver diseases, including nonalcoholic fatty liver disease (NAFLD). NAFLD often progresses to cirrhosis, end-stage liver failure and hepatocellular carcinoma (HCC), the most common primary liver cancer and one of the leading causes for cancer-related deaths globally. Currently available tools for the diagnosis of NAFLD staging and progression towards HCC are largely invasive and of limited accuracy. In light of the need for more specific and sensitive noninvasive molecular markers, several studies have assessed the potential of circulating microRNAs (miRNAs) as biomarkers of liver injury and hepatocarcinogenesis. Indeed, extracellular miRNAs are very stable in the blood, can be easily quantitated and are differentially expressed in response to different pathophysiological conditions. Although standardization procedures and larger, independent studies are still necessary, miRNAs constitute promising, clinically-useful biomarkers for the NAFLD-HCC spectrum.
Opportunities to Improve Skills and to Teach and Train Others: Employee Outcomes in the United States and Japan

Opportunities to improve skills and opportunities to teach or train others may be associated with job satisfaction, work engagement and organizational commitment. The analysis reported in this paper used a subsample of 823 employees within two Japanese and three American worksites. We tested not only the direct relationships of each type of training opportunity (to improve skills and to teach or train others) with each of three outcomes (job satisfaction, work engagement and organizational commitment) but also the potential moderating roles of performance orientation, job security and age. The relationships were assessed separately for Japanese and American respondents. The results highlight the importance of opportunities to improve skills for all three outcomes and of opportunities to teach and train for job satisfaction and work engagement. Performance orientation, job security and age generally were not significant moderators and, when they were, the effects were typically restricted to one country. The consistently positive coefficients for training opportunities should provide insight for cross‐national organizations seeking to identify human resource policies effective across varying cultural, economic and demographic contexts.
Fertility and borderline ovarian tumor: a systematic review of conservative management, risk of recurrence and alternative options.

BACKGROUND The aim of this systematic review was to evaluate the fertility outcome after borderline ovarian tumor (BOT) management and the results of conservative management, risk of recurrence and alternative options. METHODS The search strategy was based on relevant terms concerning BOT using Medline and the Central Cochrane Library. Both early and advanced stages of serous and mucinous BOT were included, but not rare entities such as endometrioid, Brenner or clear-cell BOT because of their low incidence. We considered all articles-case reports, original studies, meta-analyses and reviews-in English and French. RESULTS Overall, 230 articles were screened of which 120 were retained for review. Most pregnancies were spontaneous but some data were obtained from studies analyzing the contribution of assisted reproductive technology (ART). However, not all studies differentiated spontaneous pregnancy from those obtained after fertility treatment including ovulation induction, intrauterine insemination and IVF. Conservative management of early stage BOT resulted in a pooled estimate for spontaneous pregnancy rate of 54% with a low risk of lethal recurrence (pooled estimate: 0.5%). In patients with advanced stage BOT, the spontaneous pregnancy rates was lower (34% in the single series reporting pregnancy rate in this context) and the risk of lethal recurrence increased (pooled estimate: 2%). CONCLUSIONS This systematic review underlines that fertility subsequent to treatment of BOT depends mainly on histology and initial staging to distinguish early from advanced stages. In patients with advanced stage BOT, several alternative options to conservative management are available to allow patients to conceive without compromising their prognosis.
Promises and Lies: Can Observers Detect Deception

Although economic and social relationships can involve deception (Gneezy 2005), such relationships are often governed by informal contracts that require trust (Berg et al.1995). While important advances have been made concerning deception in economics, the research has focused little on written forms of communication. Are there certain systematic cues that signal written communications as dishonest? Are those signals accurately detected and used by message receivers? We fill this gap by studying messages written in a novel three-person trust game; (we call it the “Mistress Game”). We find that: (1) messages that use encompassing terms, or a greater number of words, are significantly more likely to be viewed as promises; and (2) promises that mention money are significantly more likely to be trusted. Notwithstanding the latter finding, we find senders who mention money within their promises to be significantly less likely to keep their word than those who do not; observers respond to cues but in the wrong way.
LIVER TRANSPLANTATION WITH REDUCED‐SIZE DONOR ORGANS

Orthotopic liver transplantation (OLT) of the pediatric patient is often limited by the availability of a size-matched donor organ. Use of reduced liver transplantation (RLT) can increase the proportion of candidates transplanted and may reduce overall mortality. We report herein the initial clinical application of RLT in the United States. Indications for RLT included fulminant hepatic failure (n=2), acute hepatic artery thrombosis (n=3), and chronic liver disease unresponsive to inpatient support and more than 30 days on transplant list (n=4). Donor hepatectomy was performed using standard techniques. Formal hepatic resection was performed ex-vivo to create a size-matched graft, from the larger donor organ, which was implanted in the orthotopic position. Between 11/84 and 4/87, 70 pediatric patients were evaluated for OLT, and 33 of these were transplanted. During this period only 5 patients (7%) died awaiting OLT. Of 33 patients treated at the University of Chicago, 5 received RLT. Donor: recipient weight ratios ranged from 2:1 to 8.1:1. For RLT median operative blood loss was 1.7 blood volumes (range 0.5–11.7) with an operative time of 9.3+3.5 hr. Acceptable early graft function was observed in five patients, all of whom were discharged from the hospital. Four of these five patients are alive between 2 and 48 months after transplantation. Marginal graft function with cholestasis and coagulopathy was associated with acute intracranial hemorrhage and neurologic death in one case. One patient died intraoperatively with non-function caused by the use of a liver from a donor with steatosis and a poor size match. Another patient died on day 5 with primary nonfunction and persistant hemorrhage. Systemic cytomegalovirus infection was the cause of death in the other two cases. RLT can provide life-sustaining liver function in urgent clinical settings. The graft can serve as a temporary or permanent liver replacement. With evolution of the technique RLT could eventually be offered to more elective candidates and increase the utilization of available donors by reducing size limitations in OLT.
Spiritual Diversity in Social Work Practice: The Heart of Helping

In Spiritual Diversity in Social Work Practice, Edward R. Canda and Leola Dyrud Furman introduce their breakthrough work on the importance of spirituality in social work teaching and practice. In this long-awaited textbook these leaders in social work education offer a first-of-its-kind integrated framework for dealing with the issues that professional helpers face. Designed for classroom use and as a reference for social workers already in the field, the book will revolutionize the way helping professionals explore the rich variety of religious and spiritual concerns of the individuals, families, and communities they serve. The authors integrate existentialist, transpersonal, and holistic systems theories with Buddhist, Christian, Hindu, Islamic, Judaic, and Shamanistic traditions of helping. They provide the knowledge, ethical guidelines, and practical skills and techniques that all social workers can follow, regardless of their particular theoretical approach. Stories, practice examples, insights from a national survey of social workers, and learning exercises support the reader's professional and personal growth.
Proceedings of the Workshop on Exploring Syntactically Annotated Corpora

This paper describes the integration of corpus-based syntactic subcate gorization frames and correlated semantic information into a large-scale, cross-theoretically informed lexical database for French (Romary et al. (2004)). This database is the first to implement the Lexica l Markup Framework (LMF), an international initiative towards ISO standards for lexical databases (ISO T C 37/SC 4). The subcategorization frames have been acquired via a dependency-based parser (Bick ( 2003)), whose verb lexicon is currently incomplete with respect to subcategorization frames. Therefore, we hav e implemented probabilistic filtering as a post-parsing treatment using the binomial distribution. Building on our disc ussion of what semantic information, e.g., participant roles, to include in the database, we describe ho w we plan to exploit our findings on subcategorization frames to derive this information via unsupervised lea rning techniques.
Coming into an inheritance: family support and Chinese Heritage Language learning

The critical role that family plays in Chinese Heritage Language learning (CHLL) has gained increasing attention from psychological, political and sociological scholarships. Guided by Bourdieu's notion of ‘habitus’, our mixed methods sociological study firstly addresses the need for quantitative evidence on the relationship between family support and Chinese Heritage Language (CHL) proficiency through a survey of 230 young Chinese Australians; and then explores the dynamics of family support of CHLL through multiple interviews with five participants. The interview data demonstrate ongoing intergenerational reproduction of CHL through various forms of family inculcation. Learners' transition from resistance to commitment is a focus of the analysis. Extant research struggles to theorise the reasons behind this transition. We offer a Bourdieusian explanation that construes the transition as ‘habitus realisation’. Our study has implications for CHL researchers, Chinese immigrant parents and Chinese teachers.
Peptides for Therapy and Diagnosis of Alzheimer’s Disease

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder with devastating effects. The greatest risk factor to develop AD is age. Today, only symptomatic therapies are available. Additionally, AD can be diagnosed with certainty only post mortem, whereas the diagnosis “probable AD” can be established earliest when severe clinical symptoms appear. Specific neuropathological changes like neurofibrillary tangles and amyloid plaques define AD. Amyloid plaques are mainly composed of the amyloid-β peptide (Aβ). Several lines of evidence suggest that the progressive concentration and subsequent aggregation and accumulation of Aβ play a fundamental role in the disease progress. Therefore, substances which bind to Aβ and influence aggregation thereof are of great interest. An enormous number of organic substances for therapeutic purposes are described. This review focuses on peptides developed for diagnosis and therapy of AD and discusses the pre- and disadvantages of peptide drugs.
Fertility intentions in a cross-cultural view: the value of children reconsidered

This paper seeks to explain the differences in fertility intentions between Turkey and Japan, based on a theoretical modification of the social-psychological concept of the ‘Value of Children’. We assume that the ‘Value of Children’ consists of their support for their parents in order to achieve general human goals. We investigate the causal structure between individual socio-economic characteristics and the ‘Value of Children’ and fertility intentions. We use data from the original “Value of Children Studies”, including women in their reproductive age, with children born in wedlock. Based on confirmatory factor analyses and structural equation models, we find that in both countries fertility intentions are related to the instrumentality of children to their parents as well as to socio-economic characteristics and institutionally defined opportunities. The ‘Value of Children’ is in part determined by socio-economic independent variables; however, we also observe direct effects that can not be reduced to the instrumentality of children. Therefore, the endogenization of the effects of the ‘Value of Children’ on fertility intentions is limited
Cutting: Understanding and Overcoming Self-Mutilation

In this work, author Steven Levenkron explains the phenomenon of self-mutilation. Written for sufferers, parents, friends and therapists, the book aims to unravel step by step the mindset of the self-mutilator. Le venkron explains why the disorder manifests in self-harming behaviour and describes how the self-mutilator can be helped. Through case-studies and conversations with his patients, the profile of the self-mutilator emerges: someone who is typically fearful of people and abandonment, whose attachments are hostile or tenuous at best, who lacks interpersonal trust and who often cannot stay focused in a relationship of any depth. In a voice that is compassionate and reassuring, "Cutting" tells the reader where to turn for help and offers information on important skills the self-mutilator must learn - what Levenkron calls the "Attachment-Dependency Trust Axis" - in order to overcome the affliction.
PENGETAHUAN DAN PENERAPAN SASARAN KESELAMATAN PASIEN PADA MAHASISWA SEMESTER 6 DI AKADEMI KEPERAWATAN ADI HUSADA SURABAYA

Patient safety incident can be done by nursing students when doing clinical practice in hospitals. This happens because of a lack of knowledge about patient safety. The purpose of this study was to identify the relationship between knowledge of patient safety with the implementation of patient safety in the 6th semester student at the Academy of Nursing Adi Husada Surabaya. This type of research is correlational, variable research is knowledge of patient safety and patient safety application. Total population of 143 and the number of samples is 131. The sampling technique is used directly probability sampling type simple random sampling. Measuring instruments used questionnaires and observation sheets. Data analysis using the spearman rank test, (α= 0.05,p=0.01,r= 0.817) indicating Ho refused meaning that there is a relationship between knowledge and application of patient safety. Results of the study recommended the need for the provision of special courses on patient safety for students in the 6th semester nursing Academy Adi Husada Surabaya. Insiden keselamatan pasien dapat dilakukan oleh mahasiswa saat melakukan praktik klinik di rumah sakit. Hal ini terjadi karena kurangnya pengetahuan tentang keselamatan pasien. Tujuan penelitian ini untuk mengidentifikasi hubungan antara pengetahuan tentang keselamatan pasien dengan penerapan keselamatan pasienpadamahasiswa semester 6 di Akademi Keperawatan Adi Husada Surabaya. Jenis penelitian ini adalah korelasional, variable penelitiannya adalah pengetahuan tentang keselamatan pasien dan penerapan keselamatan pasien. Jumlah populasi sebanyak 143 dan jumlah sampel adalah 131. Teknik sampling yang digunakan adalah probability sampling jenis simple random sampling. Alat ukur yang digunakan kuesioner dan lembar observasi. Analisis data menggunakan Spearman Rank Test, (α=0.05, p= 0.01, r=0.817) hal ini menunjukkan Ho ditolak artinya terdapat hubungan antara pengetahuan dan penerapan keselamatan pasien. Hasil penelitian merekomendasikan perlunya pemberian mata kuliah khusus tentang keselamatan pasien bagi mahasiswa semester 6 di Akademi Keperawatan Adi Husada Surabaya.
Investigating the development of children’s temporal memory across the primary school years

The examination of children’s knowledge of, and memory for, temporal information is an under-researched area. In particular, very few studies have directly examined the relationship between different aspects of temporal memory. The current thesis therefore aimed to explore whether there was a relationship between short-term, episodic and semantic temporal memory for sequencing, duration and dating performance across the primary school years. Experiment 1 revealed that children’s knowledge about time was independent of their ability to order elements within an experienced event, according to both the sequence in which the elements occurred and the duration of each element. Experiment 2 expanded upon this research; children’s short-term temporal memory for sequencing and duration was found to develop independently of their knowledge about time and their episodic memory for sequencing and duration. Finally, Experiment 4 aimed to see whether there was a relationship between children’s ability to date novel events, and their knowledge about dating concepts. This study found that these two abilities were not related during development. A further aim of this thesis was to explore whether novel methods could be employed to improve children’s temporal performance. Experiment 3 found that a counting strategy could increase the accuracy of children’s short-term duration reproductions, whilst a cumulative rehearsal technique aided children’s short-term sequencing recall. Other methods to aid temporal performance were also explored in Experiment 5; while a timeline tool was not found to increase children’s ability to sequence elements within an event, using a duration timeline was an effective way for children to represent the durations between daily activities. The implications of the current findings are highlighted, whilst further avenues of research are considered.
Open data: opportunities and challenges

Open data is seen as a promising source of new business, especially in the SME sector, in the form of new products, services and innovative solutions. High importance is seen also in fostering citizens' participation in political and social life and increasing the transparency of public authorities. The forerunners of the open data movement in the public sector are the USA and the UK, which started to open their public data resources in 2009. The first European Union open data related directive was drawn up as early as 2003; however progress in putting the idea into practice has been slow and adoptions by the wider member states are placed in the early 2010s. The beneficial use of open data in real applications has progressed hand in hand with the improvement of other ICT-related technologies. The (raw) data itself has no high value. The economic value comes from a balanced combination of high quality open (data) resources combined with the related value chain. This paper builds up a "big picture" of the role of open data in current society. The approach is analytical and it clarifies the topic from the viewpoints of both opportunities and challenges. The paper covers both general aspects related to open data and results of the research and regional development project conducted by the authors.
Testing visual angle car following models using different sets of data

The basic assumption in visual angle car following models is that the following distance between successive vehicles is a function of the object (i.e. leading vehicle) width. This paper examines the validity of this assumption using two types of data. Published real traffic data from instrumented vehicles in the USA and Germany have been used to check the ability of these models to replicate real traffic movements when both leading and following vehicles are “small cars”. Also, another type of data was used based on over 4 million cases of individual vehicles which have been abstracted from inductive loop detectors installed on the M25 and the M42 motorways in the UK. The data was then filtered and analysed to examine the following distance according to the type of the leader (i.e. Car or Heavy Goods Vehicle - HGV). The results show that while the visual angle car following models can successfully replicate real traffic movements based on the instrumented vehicles data, the assumption of leaving larger following distance if the leader is an HGV is found to be not the case for the majority of UK drivers. This will have a negative impact on the use of visual angle car following models to represent real traffic behaviour.
Exploring Mindfulness in Self-Injuring Adolescents in a Psychiatric Setting

This study explored mindfulness amongst eight self-injuring psychiatric adolescents. A mixed-method design was used. Interviews and clinical records comprised the qualitative data, while quantitative data was gathered using the Five-Facet Mindfulness Questionnaire (FFMQ: Baer, Smith, Hopkins, Krietemeyer & Toney, 2006). Thematic analysis was used to generate themes and subthemes. Findings suggest that those who sometimes act mindfully tend to be more self-critical, report more severe injuries and more often self-punish. Those who often act mindfully self-injure more often, they show more self-compassion and report less severe injuries and less lethal methods. Mindfulness-based interventions might be useful in increasing mindfulness and decreasing self-injuring behaviour in psychiatric patients.
GM-CSF upregulates the expression of CCL 2 by T lymphocytes in mammary tumor-bearing mice

(monocyte chemoattractant protein-1/CC chemokine ligand 2) is a ß or CC chemokine that is expressed by a variety of cell types, including fibroblasts, endothelial, smooth muscle, and glial cells. In addition, cells involved in immunity, such as monocytes/macrophages, neutrophils, and eosinophils have also been shown to express this chemoattractant. Using a murine model of the D1-DMBA-3 mammary adenocarcinoma, we demonstrated the unique production of CCL2 by splenic T lymphocytes from tumor-bearing animals. Because this tumor produces GM-CSF, and this factor is also up-regulated in the B lymphocytes of tumor-bearing mice, we looked at the ability of GM-CSF to induce CCL2 production by T cells. Treatment of normal and tumor bearers' T cells with GM-CSF resulted in an increased secretion of this chemokine. This up-regulation was seen with or without stimulation by Concanavalin A, although these treatments were additive in their effects. The induction of CCL2 was studied at the molecular level by analyzing the effect(s) of a variety of physiological and pharmacological agents on cultured T cells. These results suggest that the tumor-derived factor GM-CSF activates various signaling pathways within splenic T cells to up-regulate CCL2 expression.