Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of four-month vertical whole body vibration on performance and balance.

PURPOSE This randomized controlled study was designed to investigate the effects of a 4-month whole body vibration-intervention on muscle performance and body balance in young, healthy, nonathletic adults. METHODS Fifty-six volunteers (21 men and 35 women, aged 19-38 yr) were randomized to either the vibration group or control group. The vibration-intervention consisted of a 4-month whole body vibration training (4 min.d(-1), 3-5 times a week) employed by standing on a vertically vibrating platform. Five performance tests (vertical jump, isometric extension strength of the lower extremities, grip strength, shuttle run, and postural sway on a stability platform) were performed initially and at 2 and 4 months. RESULTS Four-month vibration intervention induced an 8.5% (95% CI, 3.7-13.5%, P=0.001) net improvement in the jump height. Lower-limb extension strength increased after the 2-month vibration-intervention resulting in a 3.7% (95% CI, 0.3-7.2%, P=0.034) net benefit for the vibration. This benefit, however, diminished by the end of the 4-month intervention. In the grip strength, shuttle run, or balance tests, the vibration-intervention showed no effect. CONCLUSION The 4-month whole body vibration-intervention enhanced jumping power in young adults, suggesting neuromuscular adaptation to the vibration stimulus. On the other hand, the vibration-intervention showed no effect on dynamic or static balance of the subjects. Future studies should focus on comparing the performance-enhancing effects of a whole body vibration to those of conventional resistance training and, as a broader objective, on investigating the possible effects of vibration on structure and strength of bones, and perhaps, incidence of falls of elderly people.
Selecting Optimum Cloud Availability Zones by Learning User Satisfaction Levels

Cloud service providers enable enterprises with the ability to place their business applications into availability zones across multiple locations worldwide. While this capability helps achieve higher availability with smaller failure rates, business applications deployed across these independent zones may experience different quality of service (QoS) due to heterogeneous physical infrastructures. Since the perceived QoS against specific requirements are not usually advertised by cloud providers, selecting an availability zone that would best satisfy the user requirements is a challenge. In this paper, we introduce a predictive approach to identify the cloud availability zone that maximizes satisfaction of an incoming request against a set of requirements. The prediction models are built from historical usage data for each availability zone and are updated as the nature of the zones and requests change. Simulation results show that our method successfully predicts the unpublished zone behavior from historical data and identifies the availability zone that maximizes user satisfaction against specific requirements.
The role of RelA (p65) threonine 505 phosphorylation in the regulation of cell growth, survival, and migration

RelA (p65) phosphorylation at threonine 505 acts as a negative regulator of NF-κB function. In addition to its role in regulation of cell death, a role is demonstrated for T505 phosphorylation in regulating autophagy, proliferation, and migration. NOXA is also identified as a downstream, T505-dependent effector of RelA in cell death.
Improving personal health records for patient-centered care

OBJECTIVE To assess the patient-centeredness of personal health records (PHR) and offer recommendations for best practice guidelines. DESIGN Semi-structured interviews were conducted in seven large early PHR adopter organizations in 2007. Organizations were purposively selected to represent a variety of US settings, including medium and large hospitals, ambulatory care facilities, insurers and health plans, government departments, and commercial sectors. MEASUREMENTS Patient-centeredness was assessed against a framework of care that includes: (1) respect for patient values, preferences, and expressed needs; (2) information and education; (3) access to care; (4) emotional support to relieve fear and anxiety; (5) involvement of family and friends; (6) continuity and secure transition between healthcare providers; (7) physical comfort; (8) coordination of care. Within this framework we used evidence for patient preferences (where it exists) to compare existing PHR policies, and propose a best practice model. RESULTS Most organizations enable many patient-centered functions such as data access for proxies and minors. No organization allows patient views of clinical progress notes, and turnaround times for PHR reporting of normal laboratory results can be up to 7 days. CONCLUSION Findings suggest patient-centeredness for personal health records can be improved, and recommendations are made for best practice guidelines.
Steady, dynamic, creep/recovery, and textural properties of yoghurt/molasses blends: Temperature sweep tests and applicability of Cox–Merz rule

In this study, physicochemical, rheological (steady, dynamic, and creep/recovery), and textural properties of yoghurt/molasses blends (0, 5, 10, and 15% molasses) were investigated. The blends showed shear thinning behavior, as described by Ostwald de Waele model (R2 ≥ 0.955). Consistency coefficient value (K) of the blends decreased with increasing molasses concentration in the sample. Storage modulus (G′) of blends was higher than loss modulus (G″), exhibiting weak gel-like behavior. Molasses addition decreased G′ and G″ values. Temperature sweep tests indicated that blends followed Arrhenius relationship. A modified Cox–Merz rule was applicable using shift factors. Compliance values (J(t)) increased as molasses concentration increased, revealing that deformation stability and internal viscosity (η1) decreased with concentration. Creep behavior was characterized using Burger model. Obtained J data as a function of time could be satisfactorily fitted to Burger model (R2 ≥ 0.994). The final percentage recovery of blends remarkably decreased with the increase of molasses concentration. Firmness, consistency, cohesiveness, and viscosity index values decreased with molasses addition. According to the results of the current study, molasses amount to be added to the yoghurt should be determined regarding rheological properties since resistance of the sample to deformation decreased with increase in molasses concentration.
Perceptions of diabetes obtained through drawing in childhood and adolescence

Objective To examine whether drawing is useful in the detection of problems of psychosocial adaptation in children and adolescents with type 1 diabetes (T1D) and in improving communication with health professionals. Methods We performed an exploratory descriptive study in 199 children and adolescents with T1D aged 4–13 years. The participants were asked to render a drawing on a suggested topic. The variables analyzed were related to the drawing and to clinical and sociodemographic data. Results Most participants showed evidence of having a well-balanced personality, but there were also signs of affective or psychosocial difficulties. Conclusion Drawing is a useful technique by which to identify children’s and adolescents’ feelings and possible problems in adapting to T1D, as well as to gain information directly from the children themselves. Future studies should delimit the possibilities of this technique in clinical practice in greater detail.
Cetuximab-Activated Natural Killer and Dendritic Cells Collaborate to Trigger Tumor Antigen–Specific T-cell Immunity in Head and Neck Cancer Patients

Purpose: Tumor antigen–specific monoclonal antibodies (mAb) block oncogenic signaling and induce Fcγ receptor (FcγR)–mediated cytotoxicity. However, the role of CD8+ CTL and FcγR in initiating innate and adaptive immune responses in mAb-treated human patients with cancer is still emerging. Experimental Design: FcγRIIIa codon 158 polymorphism was correlated with survival in 107 cetuximab-treated patients with head and neck cancer (HNC). Flow cytometry was carried out to quantify EGF receptor (EGFR)–specific T cells in cetuximab-treated patients with HNC. The effect of cetuximab on natural killer (NK) cell, dendritic cell (DC), and T-cell activation was measured using IFN-γ release assays and flow cytometry. Results: FcγRIIIa polymorphism did not predict clinical outcome in cetuximab-treated patients with HNC; however, elevated circulating EGFR853–861–specific CD8+ T cells were found in cetuximab-treated patients with HNC (P < 0.005). Cetuximab promoted EGFR-specific cellular immunity through the interaction of EGFR+ tumor cells and FcγRIIIa on NK cells but not on the polymorphism per se. Cetuximab-activated NK cells induced IFN-γ–dependent expression of DC maturation markers, antigen processing machinery components such as TAP-1/2 and T-helper cell (TH1) chemokines through NKG2D/MICA binding. Cetuximab initiated adaptive immune responses via NK cell–induced DC maturation, which enhanced cross-presentation to CTL specific for EGFR as well as another tumor antigen, MAGE-3. Conclusion: Cetuximab-activated NK cells promote DC maturation and CD8+ T-cell priming, leading to tumor antigen spreading and TH1 cytokine release through “NK–DC cross-talk. ” FcγRIIIa polymorphism did not predict clinical response to cetuximab but was necessary for NK–DC interaction and mAb-induced cross-presentation. EGFR-specific T cells in cetuximab-treated patients with HNC may contribute to clinical response. Clin Cancer Res; 19(7); 1858–72. ©2013 AACR.
Convergence Trends for Profitability and Payout

This study investigates the convergence patterns of return on equity (ROE) and net payout to shareholders. We show analytically and empirically that typical ROE trends are nonlinear due to the effects of transitory earnings items and equity investments (including earnings reinvestments). Accordingly, quadratic trends for profitability provide a substantially better fit than linear interpolations, especially when the magnitude of transitory items or the rate of equity investment is relatively large. The dividend component of payout is relatively stable and its slow convergence can be approximated by a linear trend. The share transactions component of payout, reflecting net share repurchases, contains a potentially large transitory part and a more permanent part that behaves similar to dividends. These findings are relevant for forming expectations regarding future values of ROE and payout, which in turn determine equity value.
Allergen challenge of peripheral blood mononuclear cells from patients with seasonal allergic rhinitis increases IL‐17RB, which regulates basophil apoptosis and degranulation

Background Previously, expression profiling has been used to analyse allergen‐challenged T‐helper type 2 cells, nasal biopsies and nasal fluid cells from patients with seasonal allergic rhinitis (SAR). Allergen‐challenged peripheral blood mononuclear cells (PBMCs) provide a human in vitro model of how antigen‐presenting cells, CD4+ T cells and effector cells such as basophils interact in allergic inflammation.
Oxide Growth Rate Enhancement of Silicon Carbide (0001) Si-Faces in Thin Oxide Regime

Thermal oxidation process of silicon carbide (SiC) has been studied by performing in-situ spectroscopic ellipsometry. In our previous work, we, for the first time, found that the growth rates of SiC(0001) C-face at oxidation thicknesses less than around 20 nm are much higher than those given by the Deal–Grove (D–G) model. In this report, we show that such a growth rate enhancement occurs also in the oxidation of SiC(0001) Si-face. By applying the empirical equation proposed by Massoud et al. [J. Electrochem. Soc. 132 (1985) 2685] to the oxidation of SiC Si-face and comparing the temperature and oxygen partial pressure dependences of oxidation rate parameters obtained with those for C-face, we discuss the difference in oxidation mechanism between SiC Si- and C-faces.
Arrhythmia Management Devices

659 Implantable cardioverter-defibrillators (ICDs) reduce sudden cardiac death risk and improve survival in patients with a history of life-threatening arrhythmia or cardiac arrest (secondary prevention) and in high-risk patients without such a history (primary prevention). Patients with ICDs, however, may receive unnecessary shocks, which have been associated with proarrhythmia, anxiety, depression, poor quality of life, and possibly increased mortality. In contrast to drug therapy, in which a limited number of parameters (such as dose) are adjustable, hundreds of programmable parameters affect device therapy delivery. Moreover, selection of nonnominal parameter settings (ie, changing the out-of-the-box factory default settings) reduces morbidity and mortality compared with nominal settings in many clinical situations because of publication and regulatory delays. Thus, optimization of programming to prevent unnecessary shocks is paramount to minimize morbidity and mortality and is dependent on clinician proactivity.
Effects of the size of cosmological N-Body simulations on physical quantities — I: Mass Function

N-Body simulations are a very important tool in the study of formation of large scale structures. Much of the progress in understanding the physics of galaxy formation and comparison with observations would not have been possible without N-Body simulations. Given the importance of this tool, it is essential to understand its limi tations as ignoring these can easily lead to interesting but unreliable results. In this paper we study the limitations due to the finite size of the simulation volume. We explicitly construct the correction term arising due to a finite box size and study its generic features for clustering o f matter and also on mass functions. We show that the correction to mass function is maximum near the scale of non-linearity, as a corollary we show that the correction to the number density of haloes of a given mass changes sign at this scale; the number of haloes at small masses is over estimated in simulations. This over estimate results from a delay in mergers that lead to formation of more massive haloes. The same technique can be used to study corrections to other physical quantities. The corrections are typically small if the scale of non-linearity i s much smaller than the box-size. However, there are some cases of physical interest in which the relative correction term is of order unity even though a simulation box much larger than the scale of non-linearity is used. Within the context of the concordance model, our analysis suggests that it is very difficult for present day simulations to resolve mass scales smaller than 10 2 M⊙ accurately and the level of difficulty increases as we go to even smaller masses, thoug h this constraint does not apply to multi-scale simulations.
Alleviation of Osmotic Stress Effects by Exogenous Application of Salicylic or Abscisic Acid on Wheat Seedlings

The aim of the study was to assess the role of salicylic acid (SA) and abscisic acid (ABA) in osmotic stress tolerance of wheat seedlings. This was accomplished by determining the impact of the acids applied exogenously on seedlings grown under osmotic stress in hydroponics. The investigation was unique in its comprehensiveness, examining changes under osmotic stress and other conditions, and testing a number of parameters simultaneously. In both drought susceptible (SQ1) and drought resistant (CS) wheat cultivars, significant physiological and biochemical changes were observed upon the addition of SA (0.05 mM) or ABA (0.1 μM) to solutions containing half-strength Hoagland medium and PEG 6000 (−0.75 MPa). The most noticeable result of supplementing SA or ABA to the medium (PEG + SA and PEG + ABA) was a decrease in the length of leaves and roots in both cultivars. While PEG treatment reduced gas exchange parameters, chlorophyll content in CS, and osmotic potential, and conversely, increased lipid peroxidation, soluble carbohydrates in SQ1, proline content in both cultivars and total antioxidants activity in SQ1, PEG + SA or PEG + ABA did not change the values of these parameters. Furthermore, PEG caused a two-fold increase of endogenous ABA content in SQ1 and a four-fold increase in CS. PEG + ABA increased endogenous ABA only in SQ1, whereas PEG + SA caused a greater increase of ABA content in both cultivars compared to PEG. In PEG-treated plants growing until the harvest, a greater decrease of yield components was observed in SQ1 than in CS. PEG + SA, and particularly PEG + ABA, caused a greater increase of these yield parameters in CS compared to SQ1. In conclusion, SA and ABA ameliorate, particularly in the tolerant wheat cultivar, the harmful effects and after effects of osmotic stress induced by PEG in hydroponics through better osmotic adjustment achieved by an increase in proline and carbohydrate content as well as by an increase in antioxidant activity.
Abortion counselling according to healthcare providers: A qualitative study in the Lisbon metropolitan area, Portugal

Objective To gain a deeper understanding of healthcare providers' perceptions on the abortion counselling they provide and its usefulness. Method We conducted in-depth interviews with 16 healthcare providers working in the Lisbon metropolitan area. The interviews were then subjected to content analysis. Results We identified the following themes on abortion counselling description: receiving the woman and understanding her request; providing information; supporting decision-making; managing emotional and psychological issues; addressing contraception; managing third-party involvement; offering psychological counselling; informing about the State's support and offering social counselling. All participants described counselling as useful but valued different aspects of it: information provision; addressing contraception to prevent future unplanned pregnancy/abortion; emotional support; decision-making support; addressing emotional issues beyond abortion; enticing women to seek healthcare in the future; preventing poor emotional post-abortion adjustment. Counselling was considered of no use to change the woman's abortion decision. Conclusion The abortion counselling provided in Portugal is in tune with the latest literature on the subject, following a client-centred approach focused on the provision of information and emotional support. It can be improved, however, particularly in what concerns the staff's communication and counselling skills. Further research is needed to improve the provision of abortion care in Portugal.
Unsupervised Geometry Calibration of Acoustic Sensor Networks Using Source Correspondences

In this paper we propose a procedure for estimating the geometric configuration of an arbitrary acoustic sensor placement. It determines the position and the orientation of microphone arrays in 2D while locating a source by direction-of-arrival (DoA) estimation. Neither artificial calibration signals nor unnatural user activity are required. The problem of scale indeterminacy inherent to DoA-only observations is solved by adding time difference of arrival (TDOA) measurements. The geometry calibration method is numerically stable and delivers precise results in moderately reverberated rooms. Simulation results are confirmed by laboratory experiments.
Carbonylated Proteins Are Detectable Only in a Degradation-Resistant Aggregate State in Escherichia coli

ABSTRACT Carbonylation is currently used as a marker for irreversible protein oxidative damage. Several studies indicate that carbonylated proteins are more prone to degradation than their nonoxidized counterparts. In this study, we observed that in Escherichia coli, more than 95% of the total carbonyl content consisted of insoluble protein and most were cytosolic proteins. We thereby demonstrate that, in vivo, carbonylated proteins are detectable mainly in an aggregate state. Finally, we show that detectable carbonylated proteins are not degraded in vivo. Here we propose that some carbonylated proteins escape degradation in vivo by forming carbonylated protein aggregates and thus becoming nondegradable. In light of these findings, we provide evidence that the accumulation of nondegradable carbonylated protein presented in an aggregate state contributes to the increases in carbonyl content observed during senescence.
Using ancient DNA techniques to identify the origin of unprovenanced museum specimens, as illustrated by the identification of a 19th century lion from Amsterdam

In natural history collections throughout Europe, there are many old lion specimens of unknown origin. If these specimens can be shown to have originated from now-extinct populations their value would significantly increase, as would the value of the collections. Recently, a 200-year old mounted skeleton in the Zoological Museum Amsterdam has been identified as the extinct Cape lion Panthera leo melanochaita (Smith, 1842), based primarily on morphological information inferred from a painting of this specimen while it was still alive. To test this hypothesis, we used ancient DNA (aDNA) techniques to extract and sequence mitochondrial DNA (mtDNA) from this specimen, and compared the genetic results with previously published lion mtDNA sequences. Our results show that the specimen is not a Cape lion, but that it instead possesses the mtDNA haplotype of the Asiatic lions P. l. persica (Meyer, 1826) from India. This Indian origin hypothesis is further supported by an investigation of its cranial morphology. As the amount of genetic information available for lions increases, in particular data from across their historic distribution, the potential for aDNA techniques to identify the origins of previously unassigned museum specimens continues to grow.
Psychosocial Well-Being Associated With Activity of Daily Living Stages Among Community-Dwelling Older Adults

Objectives: Activity of daily living (ADL) stages demonstrated ordered associations with risk of chronic conditions, hospitalization, nursing home use, and mortality among community-living elderly. This article explores the association of stages with psychosocial well-being. We hypothesized that higher ADL stages (greater ADL limitation) are associated with more restricted social networks, less perceived social support, greater social isolation, and poorer mental health. Methods: Cross-sectional data from the National Social Life, Health, and Aging Project (N = 3,002) were analyzed in regression models and latent factor models. Results: Although ADL stages had a nearly monotonic relationship with most mental health measures (e.g., Center for Epidemiologic Studies Depression Scale [CES-D]), only the complete limitation stage (Stage IV) showed significant disadvantage in the majority of social network measures. Discussion: The study may aid clinicians and policy makers to better understand the social and mental health needs of older adults at different ADL stages and provide well-planned social and mental health care.