Miracle-dz/UniFAR-FTUs huggingface dataset:
A Case Study of the Impact of Religious Accommodations on Initial Military Training

Abstract : Deputy Chief of Staff G-1 (DCS, G-1) directed ARI to examine the effect of specific religious accommodations (uniform/grooming) standards on: attaining individual Soldier skill/task proficiency, individual health and safety, unit cohesion, morale, good order, and discipline in Basic Combat Training (BCT) and Advanced Individual Training (AIT).
Molecular definition of predictive indicators of stable protein expression in recombinant NS0 myeloma cells

We have generated a molecular description of the loci at which stability/instability of expression of a monoclonal antibody (MAb) (anti‐CD38) occurs within the GS‐NS0 expression system. Critically, these data show that, in the absence of changes to copy number for the recombinant gene sequences, all cell lines examined exhibit a progressive loss (instability) in expression of mRNA during prolonged culture. However, not all cell lines express instability at the level of MAb protein production. The molecular distinction between stable and unstable production at the protein level is a reflection of the cellular amount of recombinant mRNA encoding MAb. Our data indicate a threshold level, a putative saturation point for utilisation of mRNA in translational/secretory events, that defines stability or instability of protein production. Above this level of recombinant mRNA expression, cell lines are stable, whereas below this level cell lines will show instability of protein production. Our studies indicate that absolute levels of expression of recombinant mRNA encoding for MAb in the GS‐NS0 expression system offer a potential predictive indicator for the selection of stable cell lines for scale‐up. These studies identify molecular facets of host cell biology of generic interest for gene regulation and expression and define techniques and approaches for enhancement of recombinant protein expression and process development. © 2003 Wiley Periodicals, Inc.
Systematic effects in measurement of black hole masses by emission-line reverberation of active galactic nuclei: Eddington ratio and inclination

Context. Scatter around the relationship between central black hole masses in active galactic nuclei (AGNs) obtained by reverberation-mapping methods and host-galaxy bulge velocity dispersion indicates that the masses are uncertain typically by a factor of about three. Aims. In this paper, we try to identify the sources and systematics of this uncertainty. Methods. We characterize the broad Hemission-line profiles by the ratio of their full-width at half maximum (FWHM) to their line dispersion, i.e., the second moment of the line profile. We use this parameter to separate the reverberation-mapped AGNs into two populations, the first with narrower Hlines that tend to have relatively extended wings, and the second with broader lines that are relatively flat-topped. The first population is characterized by higher Eddington ratios than the second. Within each population, we calibrate the black-hole mass scale by comparison of the reverberation-based mass with that predicted by the bulge velocity dispersion. We also use the distribution of ratios of the reverberation-based mass to the velocity-dispersion mass prediction in a comparison with a "generalized thick disk" model in order to see if inclination can plausibly account for the observed distribution. Results. We find that the line dispersion is a less biased parameter in general than FWHM for black hole mass estimation, although we show that it is possible to empirically correct for the bias introduced by using FWHM to characterize the emission- line width. We also argue that inclination effects are apparent only in some small subset of the reverberation-based mass measurements; it is primarily the objects with the narrowest emission lines that seem to be most strongly affected. Conclusions. Our principal conclusion is that the Hprofile is sensitive primarily to Eddington ratio, but that inclination effects play a role in some cases.
The Kink Effect at Cryogenic Temperatures in Deep Submicron AlGaN/GaN HEMTs

The kink effect has been studied in deep submicron AlGaN/GaN high-electron mobility transistors by measuring their DC, RF and pulsed performance at cryogenic temperatures. In these devices, the kink effect is mainly due to traps: it appears at T< 260 K and can be removed either by applying UV light or biasing the gate with short pulses. Its appearance is related to the fluorine-based treatment (CF4/O2 plasma) used for etching the passivant, treatment which creates traps below and around the gate. This link between the kink and the etching treatment has also been confirmed in optically defined gate devices with different fluorine plasma exposure times.
Language-universal constraints on speech segmentation

Two word-spotting experiments are reported that examine whether the Possible-Word Constraint (PWC) is a language-specific or language-universal strategy for the segmentation of continuous speech. The PWC disfavours parses which leave an impossible residue between the end of a candidate word and any likely location of a word boundary, as cued in the speech signal. The experiments examined cases where the residue was either a CVC syllable with a schwa, or a CV syllable with a lax vowel. Although neither of these syllable contexts is a possible lexical word in English, word-spotting in both contexts was easier than in a context consisting of a single consonant. Two control lexical-decision experiments showed that the word-spotting results reflected the relative segmentation difficulty of the words in different contexts. The PWC appears to be language-universal rather than language-specific.
Evaluation of PCR Using TRC4 and IS6110 Primers in Detection of Tuberculous Meningitis

ABSTRACT We have evaluated a new set of primers (TRC4) in comparison with the IS6110 primers commonly used in PCR to detect tuberculous meningitis among children. The levels of concordance between the results of IS6110 PCR and TRC4 PCR with cerebrospinal fluid specimens from patients with clinically confirmed tuberculous meningitis were 80 and 86%, respectively. Results with the two primer sets were concordant for 55 positive and 22 negative specimens (n = 98). We conclude that the sensitivity of PCR can be increased by using both IS6110and TRC4 primers.
AGN-selected clusters as revealed by weak lensing

As a pilot study to investigate the distribution of matter in the fields of powerful AGN, we present weak lensing observations of deep fields centered on the radio-quiet quasar E1821+643, the radio galaxy 3C 295, and the two radio-loud quasars, 3C 334 and 3C 254. The host clusters of E1821+643 and 3C 295 are comfortably detected via their weak lensing signal, and we report the detection of a cluster-sized mass concentration in the field of the z = 0.734 quasar 3C 254. The data for the 3C 334 field are so far inconclusive. We find that the clusters are massive and have smooth mass distributions, although one shows some evidence of past merger activity. The mass-to-light ratios are found to be moderately high. We discuss the results in light of the cooling flow and the merger/interaction scenarios for triggering and fuelling AGN in clusters, but find that the data do not point unambiguously to neither of the two. Instead, we speculate that sub-cluster mergers may be responsible for generating close encounters or mergers of galaxies with the central cluster member, which could trigger the AGN.
Addressing Limitations with the MM-GB/SA Scoring Procedure using the WaterMap Method and Free Energy Perturbation Calculations

The MM-GB/SA scoring technique has become an important computational approach in drug design. We, and others, have demonstrated that for congeneric molecules the correlation with experimental data obtained with the physics-based scoring is usually superior to scoring functions from typical docking algorithms. Despite showing good accuracy when applied within a series, much work is necessary to improve the MM-GB/SA method in order to gain greater efficiency in drug design. Here, we investigate the poor estimation of protein desolvation provided by the GB/SA solvation model and the large dynamic range observed in the MM-GB/SA scoring compared to that of the experimental data. In the former, replacing the GB/SA protein desolvation in the MM-GB/SA method by the free energy associated with displacing binding site waters upon ligand binding estimated by WaterMap provides the best results when ranking congeneric series of factor Xa and cyclin-dependent kinase 2 (CDK2) inhibitors. However, the improvement is modest over results obtained with the MM-GB/SA and WaterMap methods individually, apparently due to the high correlation between the free energy liberation of the displaced solvent and the protein-ligand van der Waals interactions, which in turn may be interpretable as estimates of the hydrophobic effect and hydrophobic-like interactions, respectively. As for the large dynamic range, comparisons between MM-GB/SA and FEP calculations indicate that for the factor Xa test set this problem has its origin in the lack of shielding effects of protein--ligand electrostatic interactions; that overly favors ligands that engage in hydrogen bonds with the protein.
Riesz potential operators and inverses via fractional centred derivatives

Fractional centred differences and derivatives definitions are proposed, generalizing to real orders the existing ones valid for even and odd positive integer orders. For each one, suitable integral formulations are obtained. The computations of the involved integrals lead to new generalizations of the Cauchy integral derivative. To compute this integral, a special two-straight-line path was used. With this the referred integrals lead to the well-known Riesz potential operators and their inverses that emerge as true fractional centred derivatives, but that can be computed through summations similar to the well-known Grunwald-Letnikov derivatives.
Innovation of Knowledge-based Hyper-multimedia to Promote a Culture of Using ICT Creatively for Adolescents

The purpose of the present research was to develop an innovative knowledge-based hyper-multimedia to promote a culture of using information and communication Technology (ICT) creatively for adolescents. Their learning processes and attitudes toward such innovation in their community were also examined. Thirty juveniles, 13-18 years of age in each Hangdong and Maerim districts, Chiang Mai province were employed in the study. Data collections were made through questionnaires, interview, test, group discussion and brainstorming. Analysis and evaluation were carried out with the applications of sufficient economy philosophy, constructivism theory and Torrance’s future problem-solving instructional model. Results showed that the learning innovation of hyper-multimedia presented by the use of animation, video, scene and sound with related action script synchronization was considerably effective. With the application of sufficient economy philosophy, the result indicated that performance efficiency (E1/E2) was 92.22 / 8 9.83 and the adolescents learning processes and attitudes were very good. These included purchasing of moderate ICT equipments, information screening for self-immunity and creative using of internet and ICT morally and ethically according to the computer laws. This independent learning system was properly designed for the juveniles with the right to retrieve the data or stop using at anytime. By using Torrance’s approach and constructivism theory emphasizing on brainstorming techniques, it was noted that learning process was very well adopted by the adolescents with high satisfaction. They had good attitudes toward the extension of sufficient ICT cultural using in their community with emphasis on brotherly relationship. Related organizations should educate their parents to instruct the juveniles to use the internet properly and encourage people to be aware of ICT business in order to protect social and cultural problems encountered in the future.
A theory of capitalist regulation : the US experience : with a new postface by the author

Aglietta's path-breaking book is the first attempt at a rigorous historical theory of the whole development of US capitalism, from the Civil War to the Carter presidency. A major document of the Regulation School of Marxist economists, it was received on publication as the boldest work in its field since the classic studies of Baran, Sweezy and Braverman. This edition includes a substantial new postface by Aglietta which brings regulation theory face to face with capitalism at the beginning of the new millennium.
Orally administered doxycycline accumulates in synovial fluid compared to plasma.

REASONS FOR PERFORMING STUDY Tetracycline compounds have been used to slow the progression of osteoarthritis (OA) and rheumatoid arthritis but the concentration of doxycycline attained in synovial fluid following oral, low-dose administration has yet to be determined. OBJECTIVE To determine the concentration of doxycycline in synovial fluid following oral, low-dose administration. METHODS Six mature horses received doxycycline (5 mg/kg bwt q. 12 h for 5 doses). Venous blood and synovial fluid samples were collected at t=0, 0.25, 0.5, 1, 12, 24, 48 and 72 h. Doxycycline concentrations were measured using reverse phase high pressure liquid chromatography with ultraviolet detection. RESULTS Doxycycline concentrations at all time points after t=0 were above the lower limit of quantification for the assay. Plasma concentrations of doxycycline were above 0.21 microg/ml at t=0.5 h. The mean+/-s.d. peak concentration (Cmax) of doxycycline in plasma was 0.37+/-0.22 microg/ml and time to peak concentration was 0.54+/-0.19 h. Synovial fluid concentrations of doxycycline were above 0.12 microg/ml 1 h after drug administration. The mean Cmax of doxycycline in the synovial fluid was 0.27+/-0.10 microg/ml. The penetration factor of doxycycline from plasma into synovial fluid, as determined by a ratio of the area-under-the-curve for synovial fluid:plasma during the sampling period, was 4.6. POTENTIAL RELEVANCE Orally administered doxycycline distributes easily into synovial fluid with a penetration factor of 4.6. Terminal half-life of the drug in synovial fluid was longer than in the plasma, indicating possible accumulation in this compartment. Further in vivo studies are warranted to define a medication protocol prior to routine clinical use of doxycycline for the treatment of OA.
Thrombolytic therapy in acute myocardial infarction: comparison of procoagulant effects of streptokinase and alteplase regimens with focus on the kallikrein system and plasmin.

BACKGROUND Thrombolytic therapy in patients with acute myocardial infarction (AMI) is hampered by procoagulant effects. In vitro studies have indicated that plasmin stimulation activates the kallikrein-contact-phase system, resulting in thrombin activation. This prospective comparative study was designed to examine the procoagulant effects of streptokinase or alteplase in AMI. METHODS AND RESULTS Sixty-one patients with AMI received 1.5 million U of streptokinase or front-loaded alteplase (up to 100 mg) and systemic heparin. Twenty-four patients with AMI and no thrombolytic therapy and 30 control subjects were examined for comparison. Molecular markers of thrombin, plasmin activation, and coagulation activities were determined before therapy and serially for up to 10 days. Moderate thrombin (initial thrombin-antithrombin [TAT] complex 18+/-5 versus 4+/-0.3 microg/L, P<0.05) and kallikrein (up to 45+/-4 versus 30+/-1 U/L at 3 hours, P<0.01) activation occurs in patients with AMI. D-Dimers are increased (P<0.01), and plasmin is stimulated (P<0.01). Streptokinase and alteplase increase TAT to 50+/-17 and 51+/-18 microg/L at 3 hours and to 50+/-17 and 33+/-14 microg/L at 6 hours, respectively (P<0.01). Kallikrein activity is elevated (P<0. 01) to 76+/-5 and 71+/-7 U/L at 3 hours and 64+/-6 and 47+/-5 U/L by streptokinase and alteplase, respectively, at 6 hours. Reductions in fibrinogen and increases in D-dimers and plasmin-antiplasmin complexes are more marked (P<0.05 and 0.01) after streptokinase versus alteplase. Correlations were found among TAT, kallikrein activity, and plasmin activation (P<0.01). CONCLUSIONS The data indicate a more marked procoagulant action of the streptokinase regimen compared with front-loaded alteplase, thus supporting the hypothesis of a plasmin-mediated kallikrein activation with consecutive procoagulant action in vivo.
A mathematical model of the cardiovascular system under graded exercise levels

This paper presents a nonlinear cardiovascular model for the study of cardiovascular response during graded exercise. There are two major innovations embedded in this model. Firstly, by tuning only three parameters, all major cardiovascular variables were accurately reproduced. Secondly, a robust and efficient function, which was built up using Support Vector Machine Regression, was added to the model to estimate metabolic demand. Experimental results for ten untrained males indicated that the established model is accurate in the sense that its predicted output was in good agreement with the measured data.
Ethnic and Gender Differences in the Relationship Between Hostility and Metabolic and Autonomic Risk Factors for Coronary Heart Disease

Objective: To examine the relationship between hostility and biological risk factors for coronary heart disease (CHD) in a population of white European and South Asian men and women living in the United Kingdom. Methods: This cross-sectional study involved a community-based sample of 1,757 healthy white and South Asian men and women aged between 35 years and 75 years from West London. Participants completed the Cook-Medley Hostility Scale, together with measures of standard biological risk factors and heart rate variability. Associations between hostility and CHD risk factors were evaluated, controlling for age, education, smoking, physical activity, body mass index, and waist/hip ratio, using regression models. Results: In white men, hostility was associated positively with fasting glucose, glycosylated hemoglobin, and negatively with high-density lipoprotein cholesterol. High levels of hostility were also related to increased prevalence of diabetes and the metabolic syndrome in white men. Hostility in South Asian men was associated with impaired autonomic function. Hostility was not related to any biological CHD risk factors in South Asian or white women. Conclusions: Our results showed that hostility was independently associated with glucose metabolism and dyslipidemia in white men, and with autonomic dysfunction in South Asian men. Hostility was found not to be relevant for measured CHD risk factors in females. Longitudinal data are required to establish whether the impact of hostility on CHD risk in men is mediated through metabolic and autonomic processes. CHD = coronary heart disease; LOLIPOP = London Life Sciences Prospective Population; HRV = heart rate variability; BMI = body mass index; WHR = waist/hip ratio; AF = autonomic function; HF = high-frequency; HDL = high-density lipoprotein; LDL = low-density lipoprotein.
A comparative performance study of the routing protocols LOAD and RPL with bi-directional traffic in low-power and lossy networks (LLN)

Routing protocols for sensor networks are often designed with explicit assumptions, serving to simplify design and reduce the necessary energy, processing and communications requirements. Different protocols make different assumptions - and this paper considers those made by the designers of RPL - an IPv6 routing protocol for such networks, developed within the IETF. Specific attention is given to the predominance of bi-directional traffic flows in a large class of sensor networks, and this paper therefore studies the performance of RPL for such flows. As a point of comparison, a different protocol, called LOAD, is also studied. LOAD is derived from AODV and supports more general kinds of traffic flows. The results of this investigation reveal that for scenarios where bi-directional traffic flows are predominant, LOAD provides similar data delivery ratios as RPL, while incurring less overhead and being simultaneously less constrained in the types of topologies supported.
Recombinant p 51 as Antigen in an Immune Complex Transfer Enzyme Immunoassay of Immunoglobulin G Antibody to Human Immunodeficiency Virus Type 1

An ultrasensitive enzyme immunoassay (immune complex transfer enzyme immunoassay) of antibody immunoglobulin G (IgG) to human immunodeficiency virus type 1 (HIV-1) has been developed using recombinant HIV-1 reverse transcriptase (rRT) as antigen. However, some disadvantages were noted in the use of rRT as antigen: rRT was produced only with low efficiency in widely used strains of Escherichia coli using a rather long DNA fragment (3,012 bp) of the whole HIV-1 pol gene, and it was impossible to produce fusion proteins of RT for simple purification, since rRT is a heterodimer of p66 and p51. In this study, recombinant HIV-1 p51 and p66 with Ser-Ser at the N termini (Ser-Ser-rp51 and Ser-Ser-rp66) were produced in E. coli as fusion proteins with maltose binding protein containing a factor Xa site between the two proteins and were purified after digestion with factor Xa. Ser-Ser-rp51 was produced in larger amounts and purified in higher yields with less polymerization than Ser-Ser-rp66. Polymerized Ser-Ser-rp66 tended to be precipitated on mercaptoacetylation for conjugation to b-D-galactosidase (used as a label) and showed higher nonspecific and lower specific signals in an immune complex transfer enzyme immunoassay of antibody IgG to HIV-1 than Ser-Ser-rp51. The signals for serum samples of HIV-1-seropositive subjects by immune complex transfer enzyme immunoassay of antibody IgG to HIV-1 using Ser-Ser-rp51 as antigen (Y) were well correlated to those obtained using rRT as antigen (X) (log Y 5 0.99 log X 1 0.23; r 5 0.99). Thus, the use of rp51 as antigen was advantageous over that of rp66 and rRT in an immune complex transfer enzyme immunoassay of antibody IgG to HIV-1.
Guaranteed Minimum-Rank Solutions of Linear Matrix Equations via Nuclear Norm Minimization

The affine rank minimization problem consists of finding a matrix of minimum rank that satisfies a given system of linear equality constraints. Such problems have appeared in the literature of a diverse set of fields including system identification and control, Euclidean embedding, and collaborative filtering. Although specific instances can often be solved with specialized algorithms, the general affine rank minimization problem is NP-hard because it contains vector cardinality minimization as a special case. In this paper, we show that if a certain restricted isometry property holds for the linear transformation defining the constraints, the minimum-rank solution can be recovered by solving a convex optimization problem, namely, the minimization of the nuclear norm over the given affine space. We present several random ensembles of equations where the restricted isometry property holds with overwhelming probability, provided the codimension of the subspace is sufficiently large. The techniques used in our analysis have strong parallels in the compressed sensing framework. We discuss how affine rank minimization generalizes this preexisting concept and outline a dictionary relating concepts from cardinality minimization to those of rank minimization. We also discuss several algorithmic approaches to minimizing the nuclear norm and illustrate our results with numerical examples.
The First Report of Penicillium georgiense in Malaysia

Abstract Penicillium georgiense was isolated from sandy beach soil from Batu Ferringhi beach, Penang Island, Malaysia. The identification was based on morphological characteristics and phylogenetic analysis of internal transcribed spacer regions and β-tubulin sequences. To the best of our knowledge, this is the first report of P. georgiense in Malaysia.