Miracle-dz/UniFAR-FTUs huggingface dataset:
Static and Dynamic Debugging of Modelica Models

The high abstraction level of equation-based objectoriented languages (EOO) such as Modelica has the drawback that programming and modeling errors are often hard to find. In this paper we present static and dynamic debugging methods for Modelica models and a debugger prototype that addresses several of those problems. The goal is an integrated debugging framework that combines classical debugging techniques with special techniques for equation-based languages partly based on graph visualization and interaction. To our knowledge, this is the first Modelica debugger that supports both transformational and algorithmic code debugging.
An underwater reconfigurable robot with bioinspired electric sense

Morphology, perception and locomotion are three key features highly inter-dependent in robotics. This paper gives an overview of an underwater modular robotic platform equipped with a bio-inspired electric sense. The platform is reconfigurable in the sense that it can split into independent rigid modules and vice-versa. Composed of 9 modules, the longer entity can swim like an eel over long distances, while once detached, each of its modules is efficient for small displacements with a high accuracy. Challenges are to mechanically ensure the morphology changes and to do it automatically. Electric sense is used to guide the modules during docking phases and to navigate in unknown scenes. Several aspects of the design of the robot are described and a particular attention is paid to the inter-module docking system. The feasibility of the design is assessed through experiments.
Role of CYP2B6 in Stereoselective Human Methadone Metabolism

Background:Metabolism and clearance of racemic methadone are stereoselective and highly variable, yet the mechanism remains largely unknown. Initial in vitro studies attributed methadone metabolism to cytochrome P4503A4 (CYP3A4). CYP3A4 was also assumed responsible for methadone clearance in vivo. Nevertheless, recent clinical data do not support a primary role for CYP3A4 and suggest that CYP2B6 may mediate methadone clearance. Expressed CYP2B6 and also CYP2C19 N-demethylate methadone in vitro. This investigation tested the hypothesis that CYPs 2B6, 3A4, and/or 2C19 are responsible for stereoselective methadone metabolism in human liver microsomes and in vivo. Methods:N-demethylation of racemic methadone and individual enantiomers by expressed CYPs 2B6, 2C19, and 3A4 was evaluated. Stereoselective microsomal methadone metabolism was quantified, compared with CYP 2B6 and 3A4 content, and probed using CYP isoform-selective inhibitors. A crossover clinical investigation (control, CYP2B6 and CYP3A4 induction by rifampin, CYP3A inhibition by troleandomycin and grapefruit juice) evaluated stereoselective methadone disposition. Results:At clinical concentrations, methadone enantiomer N-demethylation by recombinant CYPs 2B6, 3A4, and 2C19 was S > R, S = R, and S << R. Greater stereoselective metabolism (S > R) occurred in livers expressing high levels of CYP2B6 compared with CYP3A4. Clopidogrel, troleandomycin, and (+)-N-3-benzyl-nirvanol, selective inhibitors of CYPs 2B6, 3A4, and 2C19, respectively, inhibited microsomal methadone metabolism by 50–60%, 20–30%, and less than 10%. Only inhibition by clopidogrel was stereoselective. Clinically, rifampin diminished both R- and S-methadone plasma concentrations, but troleandomycin and grapefruit juice altered neither R- nor S-methadone concentrations. Plasma R/S-methadone ratios were increased by rifampin but unchanged by CYP3A inhibition. Conclusions:These results suggest a significant role for CYP2B6, but not CYP3A, in stereoselective human methadone metabolism and disposition.
Does the surgeon's experience have an impact on outcome after total arterial revascularization with composite T-grafts? A risk factor analysis.

OBJECTIVES When composite T-grafting is performed, total arterial revascularization (TAR) can be accomplished with only two grafts. There is the belief that composite grafting poses a risk of graft failure due to its single inflow via the left internal thoracic artery (LITA). High surgical quality is essential for left internal thoracic artery preparation, T-grafting and length estimation. We investigated whether the surgeon's experience influences postoperative outcome. METHODS We analysed the data of 1080 consecutive patients (88% male, age: 62 ± 9 years) who underwent composite T-grafting between 1996 and 2011 in our institution. Patients were operated on either by experienced surgeons (Group A) or by surgeons early on in their career (Group B). Primary end-points were mortality, myocardial ischaemia, graft dysfunction and low cardiac output syndrome. Secondary end-points were persistent neurologic deficits (PNDs), blood transfusions and re-thoracotomy. Logistic regression analysis was performed to reveal independent risk factors for adverse outcome. RESULTS Patients in Group B had a lower logistic EuroSCORE (2.8 vs 2.3%; P < 0.05), longer operative times (cross-clamp time: 41 ± 11 vs 47 ± 14 min; P < 0.001) and received less anastomoses (3.2 ± 0.7 vs 3.1 ± 0.7, P = 0.005). Mortality was low in both groups (Group A 0.6% vs Group B 0.4%; P = 1.0). Myocardial ischaemia occurred in 2.3% (Group A) and 2.5% (Group B; P = 0.82). Graft dysfunction was seen in 0.6% (Group A) and 1.4% (Group B; P = 0.25). Incidence of postoperative low cardiac output syndrome was comparable (Group A 1.4% vs Group B 0.7%; P = 0.53). Both groups showed similar incidence of secondary end-points (persistent neurologic deficit: Group A 2.9 vs 3.2% in Group B; P = 0.84; re-thoracotomy: 1.6% in Group A vs 1.8% in Group B, P = 1.0). Blood transfusions were more common in Group B (P = 0.005). Less surgical experience could only be identified as an independent risk factor for blood transfusion (P = 0.001). CONCLUSIONS Total arterial revascularization with composite T-grafts can be performed safely by surgeons with different surgical experience. Despite differences in surgical performance parameters (e.g. operation times, blood transfusions), complication rates were extremely low, irrespective of the surgeon's operative experience. Surgeons can be introduced to these procedures in an early phase of training.
The role of adipokines in chronic inflammation

Adipose tissue has traditionally been defined as connective tissue that stores excess calories in the form of triacylglycerol. However, the physiologic functions attributed to adipose tissue are expanding, and it is now well established that adipose tissue is an endocrine gland. Among the endocrine factors elaborated by adipose tissue are the adipokines; hormones, similar in structure to cytokines, produced by adipose tissue in response to changes in adipocyte triacylglycerol storage and local and systemic inflammation. They inform the host regarding long-term energy storage and have a profound influence on reproductive function, blood pressure regulation, energy homeostasis, the immune response, and many other physiologic processes. The adipokines possess pro- and anti-inflammatory properties and play a critical role in integrating systemic metabolism with immune function. In calorie restriction and starvation, proinflammatory adipokines decline and anti-inflammatory adipokines increase, which informs the host of energy deficits and contributes to the suppression of immune function. In individuals with normal metabolic status, there is a balance of pro- and anti-inflammatory adipokines. This balance shifts to favor proinflammatory mediators as adipose tissue expands during the development of obesity. As a consequence, the proinflammatory status of adipose tissue contributes to a chronic low-grade state of inflammation and metabolic disorders associated with obesity. These disturbances are associated with an increased risk of metabolic disease, type 2 diabetes, cardiovascular disease, and many other pathological conditions. This review focuses on the impact of energy homeostasis on the adipokines in immune function.
Social Support As a Moderating Factor Between Mental Health Disruption and College Adjustment in Student Veterans

Research has indicated that OEF/OIF veterans are experiencing mental health concerns following deployment. While there are increasing numbers of veterans returning to higher education institutions after discharging from the military, there is a scarcity of empirical research investigating student veterans’ experiences as they transition into college. The purpose of the current study was to examine whether social support moderates the effects of psychological distress on college adjustment among a sample of student veterans. Participants were administered a Background Information Questionnaire, measures of psychological distress (i.e., GAD-7, PHQ-9, IES-R), Multidimensional Scales of Perceived Social Support, and the Student Adjustment to College Questionnaire. Multiple regressions revealed significant main effects for the variables of interest, but analyses failed to support the hypothesis that perceived social support would moderate the effects of psychological distress on college adjustment.
Fast tracking after Ivor Lewis esophagogastrectomy.

OBJECTIVES We streamlined our care using an algorithm for the postoperative care of patients who undergo Ivor Lewis esophagogastrectomy to try to reduce hospital stay to 7 days and maintain safety and patient satisfaction. METHODS A consecutive series of 90 patients who underwent elective esophageal resection by one general thoracic surgeon were studied. An algorithm to guide postoperative care was used, featuring avoidance of the ICU, early ambulation, jejunal tube feeds starting on postoperative day (POD) 1, removal of nasogastric tube and epidural on POD 3, a gastrograffin swallow on PODs 4 or 5, and discharge on POD 7. RESULTS There were 90 patients (70 men). Fifty-two patients (58%) underwent preoperative radiation and chemotherapy. Esophagectomies were done for cancer or high-grade dysplasia. Forty-two of the last 55 patients (77%) went directly to the floor. Sixteen patients (17.7%) had major complications, which included pneumonia in 5 patients and aspiration pneumonia in 4 patients. There were no anastomotic leaks, and there were four operative deaths (4.4%). There was a greater incidence of failure to fast track, and to have a major complication in patients who underwent neoadjuvant treatment (p = 0.025 and p = 0.048, respectively). Median hospital stay was 7 days (range, 6 to 74 days). Complications or mortality could not be definitively attributed to fast tracking. Ninety-seven percent reported excellent satisfaction with their hospital stay, and four patients were readmitted within 1 month of discharge. CONCLUSIONS Fast tracking patients using an algorithm after esophageal resection is safe and delivers minimal morbidity and mortality, and a high patient satisfaction rate. A median hospital stay of 7 days is possible, and the ICU can be avoided in most patients.
A conditional entropy power inequality for dependent variables

We provide a condition under which a version of Shannon's entropy power inequality will hold for dependent variables. We first provide a Fisher information inequality extending that found in the independent case. The key ingredients are a conditional expectation representation for the score function of a sum, and the de Bruijn identity which relates entropy and Fisher information.
On Context-Dependent Clustering of Bandits

We investigate a novel cluster-of-bandit algorithm CAB for collaborative recommendation tasks that implements the underlying feedback sharing mechanism by estimating the neighborhood of users in a context-dependent manner. CAB makes sharp departures from the state of the art by incorporating collaborative effects into inference as well as learning processes in a manner that seamlessly interleaving explore-exploit tradeoffs and collaborative steps. We prove regret bounds under various assumptions on the data, which exhibit a crisp dependence on the expected number of clusters over the users, a natural measure of the statistical difficulty of the learning task. Experiments on production and real-world datasets show that CAB offers significantly increased prediction performance against a representative pool of state-of-the-art methods.
Is Drinking to Thirst Optimum?

Backgrounds/Aims: Prior to 1969, athletes were advised to avoid drinking during exercise. At least 4 subsequent events led to the adoption of a radically different approach. By 1996, all exercisers were advised to drink ‘as much as tolerable’ in order to insure that they did not lose any weight during exercise – the ‘zero percent dehydration’ doctrine. This advice requires that athletes drink enough to ‘stay ahead of thirst’. The act of drinking is a basic survival instinct that has been regulated by complex, unconscious controls ever since the first fish-like creatures moved onto land and should not require conscious adjustment. Methods: Literature survey of all studies comparing the effects of drinking to thirst (ad libitum) and drinking to prevent any weight loss during exercise – the ‘zero percent dehydration’ doctrine. Result: No study found that drinking more than ad libitum during exercise produced any biological advantage, but it could cause exercise-associated hyponatremia. Conclusion: Drinking ad libitum appears to optimize performance and safety during exercise in many situations. The presence of thirst, not of water loss, may be the biological signal that impairs exercise performance in those who drink less than their thirst dictates during exercise.
Skill acquisition in sport: Research, theory and practice

Preface - NICOLA HODGES and MARK WILLIAMS I. PRESENTING INFORMATION 1. The roles and uses of augmented feedback in motor skill acquisition - RICHARD MAGILL and DAVID ANDERSON 2. Mixing it up a little: How to schedule observational practice - NICOLE ONG and NICOLA HODGES 3. Attentional focus affects movement efficiency - KEITH LOHSE, GABRIELE WULF and REBECCA LEWTHWAITE 4. Advances in implicit motor learning - RICHARD S. W. MASTERS and JAMIE POOLTON II: OPTIMIZING PRACTICE CONDITIONS 5. Scheduling practice - TIMOTHY LEE 6. Mental imagery, action observation and skill learning - AIDAN MORAN, MARK CAMPBELL, PAUL HOLMES and TADHG MACINTYRE 7. Ecological dynamics and motor learning design in sport - KEITH DAVIDS, DUARTE ARAUJO, ROBERT HRISTOVSKI, PEDRO PASSOS AND JIA YI CHOW 8. The representation, production, and transfer of simple and complex movement sequences - CHARLES SHEA and DAVID WRIGHT 9. Physical guidance research: Assisting principles and supporting evidence - NICOLA HODGES and PAUL CAMPAGNARO III: ISSUES IN MOTOR LEARNING 10. Motor learning through a motivational lens - REBECCA LEWTHWAITE and GABRIELE WULF 11. Motor skill consolidation - MAXIME TREMPE and LUC PROTEAU 12. Critical periods, readiness and skill learning - DAVID ANDERSON, RICHARD MAGILL and REGIS THOUVARECQ 13. Mechanisms of skilled joint action performance - TERRY ESKENAZI, ROBRECHT VAN DER WEL and NATALIE SEBANZ 14. Motor skill learning and its neurophysiology - KATIE WADDEN, MICHAEL BORICH and LARA BOYD IV: SKILLED PERFORMANCE 15. The development of skill in sport - JEAN COTE, JENNIFER MURPHY MILLS and BRUCE ABERNETHY 16. Experts have all the time in the world - BRUCE ABERNETHY, DAMIAN FARROW, ADAM GORMAN and DAVID MANN 17. Perceptual expertise: what can be trained? JOE CAUSER, CHRISTOPHER JANELLE, JOAN VICKERS and A. MARK WILLIAMS 18. Embodied cognition: from the playing field to the classroom - CARLY KONTRA, NEIL ALBERT and SIAN BEILOCK 19. Especial skills: generality and specificity in motor learning - GAVIN BRESLIN, RICHARD SCHMIDT and TIMOTHY LEE V: RESEARCH, THEORY & PRACTICE: CHALLENGES & SOLUTIONS 20. Translating Theory into Practice: Working at the 'Coal Face' in the UK! - A. MARK WILLIAMS, PAUL FORD, JOE CAUSER, OLIVER LOGAN and STAFFORD MURRAY 21. Working in the field: A Southern hemisphere perspective - CHRIS BUTTON and DAMIAN FARROW
Parasitic cysts of the liver - practical approach to diagnosis and differentiation.

BACKGROUND The aim of the study was to determine the incidence of parasitic liver cysts. MATERIAL AND METHODS In 1996-2000 at the Department of Infectious Diseases parasitic liver cysts were diagnosed in 31 patients. The diagnosis was based on imaging examinations (ultrasound, computerised tomography), serological reactions (ELISA, IHA) and histopathological investigation of the specimens obtained through fine-needle aspiration biopsy. RESULTS AND CONCLUSION The latter followed the pre-treatment with antiparasitic drug and no significant complications were observed. On the basis of the criteria developed by our team (evident, highly probable and probable diagnosis), hydatid disease of the liver was diagnosed in 8 patients (25.8%). The remaining subjects, excluding one patient who underwent surgical treatment, received repeated treatment with imidazole derivatives (Zentel or Vermox).
Use of an Immunoperoxidase Test for the Detection of Bovine Herpesvirus-1 in Aborted Fetal Tissue

An indirect immunoperoxidase (IP) procedure using a specific monoclonal antibody and an avidinbiotin-peroxidase complex was developed and applied to detect virus antigen in formalin-fixed, paraffin-embedded tissue sections. This IP procedure was compared with currently used diagnostic tests for detection of virus-induced abortions caused by bovine herpesvirus-1 (BHV–1). The IP procedure was applied to detect BHV-1 antigen in sections of liver and lung from 87 aborted fetuses. Sixteen of these cases were positive for viral antigen by IP staining. Sections from both liver and lung were positive in 15 of the 16 cases. A fluorescent antibody test (FA), which was applied to acetone-fixed frozen sections of liver and lung, gave positive results on 12 of the 87 fetuses, 11 of which were also positive by IP. Seven of the 12 FA-positive cases were positive on both sections of liver and lung. When FA and IP were compared, FA had a sensitivity of 67% and IP had a sensitivity of 94%. Virus was isolated from one of the 67 cases tested. The tissues in which antigen was most frequently detected by IP were liver, lung, and kidney. Distinct multifocal staining was seen in positive sections of all these tissues.
A Novel Triband E-Shaped Printed Monopole Antenna for MIMO Application

A novel multiband E-shaped printed monopole antenna for multiple-input-multiple-output (MIMO) system is presented. The proposed E-shaped monopole antenna can create a single resonance within the WLAN range. Placement of two slots within the E-shaped monopole antenna creates two extra resonances whose center frequencies can be adjusted by the E-shaped monopole and the slots parameters. The antenna parameters for WLAN application, covering 2.4, 5.4, and 5.8 GHz, are given. Various configurations of array of this E-shaped monopole antenna for MIMO application are also studied. It is shown that good MIMO performance can be achieved even for small element spacing. Simulation and measurement results are compared and discussed.
Can AI planners solve practical problems?

While there has been recent interest in research on planning and reasoning about actions, nearly all research results have been theoretical. We know of no previous examples of a planning system that has made a significant impact on a problem of practical importance. One of the primary goals during the development of the SIPE‐2 planning system has been the balancing of efficiency with expressiveness and flexibility. With a major new extension, SIPE‐2 has begun to address practical problems. This paper describes this new extension and the new applications of the planner. One of these applications is the problem of producing products from raw materials on process lines under production and resource constraints. This is a problem of commercial importance and SiPE‐2's application to it is described in some detail.
Aging mothers and their adult daughters : a study in mixed emotions

The mother/daughter tie is one that persists well past childhood and it takes on unique characteristics as daughter enter midlife and mothers enter old age. Incorporating vivid descriptions by mothers and daughters about their relationships, this book addresses both the rewards and the costs that mothers and daughters incur in maintaining their relationships into old age. It is useful for psychologists, gerontologists, and sociologists, as well as academics and researchers in women's and family studies.
Thymidylate synthetase inhibition in malignant tumors and normal liver of patients given intravenous 5-fluorouracil.

Single surgical biopsies of solid tumor were obtained at 20 to 240 min after drug administration in 21 patients given first-dose bolus i.v. 5-fluorouracil (5-FUra), 500 mg/sq m, and assayed for 5-fluorodeoxyuridylate (FdUMP), deoxyuridylate (dUMP), total thymidylate synthetase (TS), and non-FdUMP-bound, free enzyme. Nineteen patients had cancer of gastrointestinal origin, 13 of these colorectal, and 2 patients had breast adenocarcinoma. In 9 patients, synchronous biopsies of surgically normal liver were obtained along with samples of hepatic tumors metastatic from gastrointestinal sites. Total TS averaged 4.18 pmol/g in the malignant tissues and 2.23 pmol/g in liver. FdUMP levels in the gastrointestinal tumors were higher than in normal liver, were highest at the earliest time interval studied, 20 to 30 min, and appeared to decrease exponentially through 120 min. TS inhibition averaged 70 to 80% in gastrointestinal tumor biopsies and less than 50% in normal liver. Levels of dUMP were low and varied little with time. Those gastrointestinal tumors with higher FdUMP:dUMP ratios showed significantly greater TS inhibition. Tumors of 3 patients who benefited from 5-FUra therapy (1 patient with colonic adenocarcinoma and the 2 patients with breast adenocarcinoma) showed greater TS inhibition than did tumors of remaining patients. It is concluded that the apparent time course changes observed in FdUMP, dUMP, and TS in the grouped data are qualitatively similar to findings of murine studies in vivo and that the relationship between FdUMP:dUMP ratios and TS inhibition are consistent with established in vitro enzymic kinetics. Thus, biopsies of tumors at short time periods after 5-FUra administration may be usefully studied for biochemical parameters of TS inhibition, with the objectives of correlation of sensitivity to subsequent 5-FUra therapy and clarification of mechanisms of drug resistance.