Miracle-dz/UniFAR-FTUs huggingface dataset:
Genetic Diversity and Genetic Differentiation in Daphnia Metapopulations With Subpopulations of Known Age

If colonization of empty habitat patches causes genetic bottlenecks, freshly founded, young populations should be genetically less diverse than older ones that may have experienced successive rounds of immigration. This can be studied in metapopulations with subpopulations of known age. We studied allozyme variation in metapopulations of two species of water fleas (Daphnia) in the skerry archipelago of southern Finland. These populations have been monitored since 1982. Screening 49 populations of D. longispina and 77 populations of D. magna, separated by distances of 1.5–2180 m, we found that local genetic diversity increased with population age whereas pairwise differentiation among pools decreased with population age. These patterns persisted even after controlling for several potentially confounding ecological variables, indicating that extinction and recolonization dynamics decrease local genetic diversity and increase genetic differentiation in these metapopulations by causing genetic bottlenecks during colonization. We suggest that the effect of these bottlenecks may be twofold, namely decreasing genetic diversity by random sampling and leading to population-wide inbreeding. Subsequent immigration then may not only introduce new genetic material, but also lead to the production of noninbred hybrids, selection for which may cause immigrant alleles to increase in frequency, thus leading to increased genetic diversity in older populations.
Summary of the evidence of breast cancer service screening outcomes in Europe and first estimate of the benefit and harm balance sheet

Accepted for publication 13 June 2012 . Objectives To construct a European ‘balance sheet’ of key outcomes of population-based mammographic breast cancer screening, to inform policy-makers, stakeholders and invited women. Methods From the studies reviewed, the primary benefit of screening, breast cancer mortality reduction, was compared with the main harms, over-diagnosis and false-positive screening results (FPRs). Results Pooled estimates of breast cancer mortality reduction among invited women were 25% in incidence-based mortality studies and 31% in case-control studies (38% and 48% among women actually screened). Estimates of over-diagnosis ranged from 1% to 10% of the expected incidence in the absence of screening. The combined estimate of over-diagnosis for screened women, from European studies correctly adjusted for lead time and underlying trend, was 6.5%. For women undergoing 10 biennial screening tests, the estimated cumulative risk of a FPR followed by noninvasive assessment was 17%, and 3% having an invasive assessment. For every 1000 women screened biennially from age 50–51 until age 68–69 and followed up to age 79, an estimated seven to nine lives are saved, four cases are over-diagnosed, 170 women have at least one recall followed by non-invasive assessment with a negative result and 30 women have at least one recall followed by invasive procedures yielding a negative result. Conclusions The chance of saving a woman’s life by population-based mammographic screening of appropriate quality is greater than that of over-diagnosis. Service screening in Europe achieves a mortality benefit at least as great as the randomized controlled trials. These outcomes should be communicated to women offered service screening in Europe.
Exact capacity distribution for dual MIMO systems in Ricean fading

It is well known that multiple input multiple output (MIMO) systems offer the promise of achieving very high spectrum efficiencies (many tens of bit/s/Hz) in a mobile environment. The gains in MIMO capacity are sensitive to the type of channel encountered in the radio environment. To date most analytical work has concentrated on Rayleigh fading channels. Hence, in this letter we consider the capacity outage performance of MIMO systems in Ricean channels. Due to analytical complexity we concentrate on dual antenna systems (either two transmit or two receive antennas) and derive exact densities and distribution functions for the capacity.
The distribution of tenascin-X is distinct and often reciprocal to that of tenascin-C

We have isolated a cDNA encoding mouse tenascin-X (TN-X), a new member of the family of tenascin genes. The TN-X gene lies in the major histocompatibility complex (MHC) class III region, as it is the case for its human counterpart. On Northern blots we detected a TN-X mRNA of approximately 13 kb in most tissues analyzed, whereas in various mouse cell lines mRNAs of approximately 11 and 13 kb were detected, suggesting the possibility of alternative splicing of TN-X transcripts. We raised antibodies against mouse TN-X fragments expressed in bacteria and used these antibodies to identify the TN-X protein in heart cell extracts and in the conditioned medium of a renal carcinoma cell line. The subunit molecular size of TN-X is approximately 500 kD, suggesting that the protein may contain up to 40 fibronectin type III repeats, making it the largest tenascin family member known yet. TN-X in conditioned medium, as well as the purified protein bind to heparin, but no binding to tenascin-C (TN-C), fibronectin, laminin or collagens could be detected. Thus the heparin-binding activity may be a common feature of the tenascins. The TN-X mRNA as well as the protein are predominantly expressed in heart and skeletal muscle, but the mRNA is found in most tissues at a low level. Immunostaining showed the protein to be associated with the extracellular matrix of the muscle tissues and with blood vessels in all of the tissues analyzed. Although the TN- X gene lies in the MHC class III locus, it is not expressed in the lymphoid organs analyzed, except for the staining around blood vessels. In skin and tissues of the digestive tract often a reciprocal distribution of TN-X and TN-C was observed.
Counting without sampling: new algorithms for enumeration problems using statistical physics

We propose a new type of approximate counting algorithms for the problems of enumerating the number of independent sets and proper colorings in low degree graphs with large girth. Our algorithms are not based on a commonly used Markov chain technique, but rather are inspired by recent developments in statistical physics in connection with correlation decay properties of Gibbs measures and its implications to uniqueness of Gibbs measures on infinite trees, reconstruction problems and local weak convergence methods. On a negative side, our algorithms provide ∈-approximations only to the logarithms of the size of a feasible set (also known as free energy in statistical physics). But on the positive side, unlike Markov chain based algorithms, our approach provides deterministic as opposed to probabilistic guarantee on approximations. Moreover, for some regular graphs we obtain explicit values for the counting problem. For example, we show that every 4-regular n-node graph with large girth has asymptotically (1.494 .)n independent sets, and in every r-regular graph with n nodes and large girth the number of q ≥ r + 1-proper colorings is asymptotically (q(1-1/q)r/2)n for large n. In statistical physics terminology, we compute explicitly the partition function (free energy) in these cases. We extend our results to random regular graphs graphs also. The explicit results obtained in this paper would be hard to derive via Markov chain sampling technique.
Working memory and symptoms of attention deficit hyperactivity disorder in children

Attention Deficit Hyperactivity Disorder (ADHD) is a disorder mainly characterized by high levels of inattention, hyperactivity, and impulsiveness. Although ADHD is a topic of great interest in multiple domains, much remains to be explored before a thorough understanding will be possible. Recently, working memory (WM) has gained attention as a potential core deficit of ADHD. Therefore, theories of ADHD and WM may provide guidance for increased understanding of ADHD, and continued research on ADHD, guided by WM theory, will maximize the effectiveness of assessment and treatment for this disorder. The current study utilized a model integrating WM measurement and symptoms of ADHD. To investigate the relationship between continuous measurement of ADHD symptoms and WM functioning, experimental paradigms and clinical assessment of WM capacity were utilized. Results indicated computerized change-detection tasks are not effectively eliciting WM in children, as capacity was significantly lower than that of adults. A trend for developmental increase in WM was found. The WISC-IV Arithmetic subtest was the subtest most consistently related to other clinical and experimental WM measures. The Arithmetic and Digit Span Backward subtests were most consistently related to ADHD inattentive symptoms though significant variance was still unaccounted for, and no WM measure was consistently related to ADHD hyperactive/impulsive symptoms. Overall, continuous measurement of ADHD inattentive symptoms best characterized relationships between ADHD and WM functioning, and WM did not have utility in categorical classification of ADHD. Results highlight the need for advancement in WM measurement, as well as the utility of continuous characterization of dis-
Dietary fiber and the glycemic index: a background paper for the Nordic Nutrition Recommendations 2012

The aim of this study is to review recent data on dietary fiber (DF) and the glycemic index (GI), with special focus on studies from the Nordic countries regarding cardiometabolic risk factors, type 2 diabetes, cardiovascular disease, cancer, and total mortality. In this study, recent guidelines and scientific background papers or updates on older reports on DF and GI published between 2000 and 2011 from the US, EU, WHO, and the World Cancer Research Fund were reviewed, as well as prospective cohort and intervention studies carried out in the Nordic countries. All of the reports support the role for fiber-rich foods and DF as an important part of a healthy diet. All of the five identified Nordic papers found protective associations between high intake of DF and health outcomes; lower risk of cardiovascular disease, type 2 diabetes, colorectal and breast cancer. None of the reports and few of the Nordic papers found clear evidence for the GI in prevention of risk factors or diseases in healthy populations, although association was found in sub-groups, e.g. overweight and obese individuals and suggestive for prevention of type 2 diabetes. It was concluded that DF is associated with decreased risk of different chronic diseases and metabolic conditions. There is not enough evidence that choosing foods with low GI will decrease the risk of chronic diseases in the population overall. However, there is suggestive evidence that ranking food based on their GI might be of use for overweight and obese individuals. Issues regarding methodology, validity and practicality of the GI remain to be clarified.
Boredom-Induced Switching Behavior in the Restaurant Industry: The Mediating Role of Attachment

While it is well documented that boredom with a particular product or service can result in switching behavior, the extent to which emotional attachment can affect this relationship is not well understood. The purpose of this research is to address this gap in the literature by exploring the role of place attachment in the relationships among boredom, satisfaction, and switching behavior in the domain of full-service restaurant patronage. The results indicate that while boredom can, in fact, result in switching intentions (particularly to unfamiliar alternatives), the reduction/elimination of boredom can actually lead to feelings of attachment that subsequently translate into lower levels of switching intention. The findings enhance the theoretical understanding of both restaurant switching behavior and hedonic adaptation in several important ways as well as provide meaningful implications for restaurant marketers interested in minimizing switching behavior attributable to repeat visitation and boredom.
Size of Multilayer Networks for Exact Learning: Analytic Approach

This article presents a new result about the size of a multilayer neural network computing real outputs for exact learning of a finite set of real samples. The architecture of the network is feedforward, with one hidden layer and several outputs. Starting from a fixed training set, we consider the network as a function of its weights. We derive, for a wide family of transfer functions, a lower and an upper bound on the number of hidden units for exact learning, given the size of the dataset and the dimensions of the input and output spaces.
Social cognition and transcranial stimulation of the temporoparietal junction

This study examined behavioural and electrophysiological effects of transcranial stimulation on social cognitive abilities. Positive effects on aspects of emotion processing were observed, which were also related to neurophysiological markers. Stimulation also interacted with autism-relevant trait scores, underlining the relevance of this research to potential clinical applications.
Inflation Targeting: Lessons from the International Experience

List of FiguresPrefacePt. 1Inflation Targeting: The Issues11Introduction32The Rationale for Inflation Targeting103Issues of Design and Implementation26Pt. 2Case Studies and Empirical Evidence394German and Swiss Monetary Targeting: Precursors to Inflation Targeting415New Zealand: Inflation-Targeting Pioneer866Canada: Inflation Targets as Tools of Communication1157United Kingdom: The Central Bank as Counterinflationary Conscience1458Sweden: Searching for a Nominal Anchor1729Three Small Open Economies: Israel, Australia, and Spain20310Inflation Targeting: How Successful Has It Been? 252Pt. 3Conclusions28511What Have We Learned? 28712Inflation Targeting for the United States and the European Monetary Union309Notes335References355Index367
As Time Goes by: A Simple Fool's Guide to Molecular Clock Approaches in Invertebrates*

Abstract: Biologists have used a wide range of organisms to study the origin of taxa and their subsequent evolutionary change in space and time. One commonly used tool is the molecular clock approach, relating substitution rates of nucleotide or amino acid sequences to divergence times. The accuracy of the molecular clock, however, has long been subject to controversy, and numerous papers have addressed problems associated with estimating divergence times. Some workers pointed out a striking imbalance between sophisticated software algorithms used for molecular clock analyses on the one hand, and the poor data on the other hand. Moreover, there is often unease among workers relative to molecular clocks because of the controversy surrounding the approach, the complex mathematical background of many molecular clock tools, the still limited number of available, user-friendly software packages, the often confusing terminology of molecular clock approaches, and the general lack of reliable calibration points and/or external clock rates. The current review therefore briefly provides an overview of analytical strategies, covering approaches based on calibration points and/or bounds, approaches based on external clock rates, and approaches that attempt to estimate relative divergence times in the absence of information that can be used for estimating substitution rates. It also deals with major problems and pitfalls associated with data and analyses, including potential errors of calibration points and bounds, the performance of the gene(s) used, estimation of confidence limits, and misinterpretation of the results of clock analyses due to problems with sampling design. A substantial part of the review addresses the question of “universal” molecular clock rates and summarizes important biological and life history variables that account for deviations from rate constancy both between lineages and at different times within lineages. The usefulness of these factors is discussed within the framework of “trait-specific” molecular clock rates. One such clock rate is introduced here for the cytochrome c oxidase subunit I (COI) gene in small dioecious, tropical and subtropical Protostomia with a generation time of approximately one year. A flow chart is provided as a “simple fool's guide” to molecular clock analyses, together with a glossary of widely used terms in molecular clock approaches. Finally, step-by-step examples are provided for calculating divergence times in the caenogastropod subfamily Pyrgulinae based on both an internal calibration point and a “trait-specific” molecular clock rate, and it is demonstrated how a relative clock approach can be used for testing evolutionary hypotheses. Our review encourages a judicious use of molecular clock analyses in evolutionary studies of invertebrates by demonstrating their great potential on the one hand and (often-manageable) problems and pitfalls on the other hand.
New Image Quality Evaluation Metric for Underwater Video

This work presents a new vectorial underwater image quality metric, dubbed the CQ, that integrates the power spectrum. Unlike existing objective underwater image quality metrics, the proposed metric consists of a discriminator C based on the slope of the log-contrast power spectrum that is able to distinguish between marine habitats when a large number of images of different environments are to be processed, and a patch-based metric Q to predict the objective quality of underwater images. Experimental results illustrate that the proposed CQ metric is able to recognize underwater images with similar sharpness and correlates better with enhancement results compared to other methods, and also meet real-time requirements.
Log-time and Log-space Extreme Classification

We present LTLS, a technique for multiclass and multilabel prediction that can perform training and inference in logarithmic time and space. LTLS embeds large classification problems into simple structured prediction problems and relies on efficient dynamic programming algorithms for inference. We train LTLS with stochastic gradient descent on a number of multiclass and multilabel datasets and show that despite its small memory footprint it is often competitive with existing approaches.
Long-Term Spectral and Timing Behavior of the Black Hole Candidate XTE J1908+094

We present the long-term X-ray light curves and detailed spectral and timing analyses of XTE J1908+094 using the Rossi X-Ray Timing Explorer Proportional Counter Array observations covering two outbursts in 2002 and early 2003. At the onset of the first outburst, the source was found in a spectrally low/hard state lasting for ~40 days, followed by a 3 day long transition to the high/soft state. The source flux (in 2-10 keV) reached ~100 mcrab on 2002 April 6, then decayed rapidly. In power spectra, we detect strong band-limited noise and varying low-frequency quasi-periodic oscillations that evolved from ~0.5 to ~5 Hz during the initial low/hard state of the source. We find that the second outburst closely resembled the spectral evolution of the first. The X-ray transient's overall outburst characteristics led us to classify XTE J1908+094 as a black hole candidate. Here we also derive precise X-ray position of the source using Chandra observations that were performed during the decay phase of the first outburst and following the second outburst.
Photochemical Internalization of Therapeutic Macromolecular Agents: A Novel Strategy to Kill Multidrug-Resistant Cancer Cells

Drug resistance is a major problem for chemotherapy. Entrapment of anticancer drugs in endolysosomal compartments or active extrusions by plasma membrane proteins of the ATP-binding cassette (ABC) superfamily are important resistance mechanisms. This study evaluated photochemical internalization (PCI) of membrane-impermeable macromolecules that are not the target of ABC drug pumps for treating multidrug-resistant (MDR) cancer cells. We used the drug-sensitive uterine fibrosarcoma cell line MES-SA and its MDR, P-glycoprotein (P-gp)-overexpressing derivative MES-SA/Dx5 with the photosensitizer disulfonated meso-tetraphenylporphine (TPPS2a) and broad spectrum illumination. The PCI of doxorubicin, the ribosome-inactivating protein gelonin and adenoviral transduction were assessed in both cell lines, together with the uptake and excretion of TPPS2a and of two fluid phase markers easily detectable by fluorescence [lucifer yellow (LY) and fluorescein isothiocyanate (FITC)-dextran], as a model of gelonin uptake. Both cell lines were resistant to PCI of doxorubicin, but equally sensitive to PCI of gelonin, even though the endocytosis rates of LY and FITC-dextran were significantly lower in the MDR cells. In control studies, MES-SA/Dx5 cells were more resistant to photodynamic therapy (TPPS2a + light only). This was not mediated by P-gp, as there were no differences in the uptake and efflux of TPPS2a between the cell lines. After adenoviral infection, PCI enhanced gene delivery in both cell lines. In conclusion, PCI of macromolecular therapeutic agents that are not targets of P-gp is a novel therapeutic strategy to kill MDR cancer cells.
www.econstor.eu Zentrum für Europäische Integrationsforschung Center for European Integration Studies

This paper derives a stochastic endogenous growth model that investigates the impact of European Union integration on convergence and productivity growth. We deviate from the general strand of literature by not only deriving a theoretical model for the effects of integration on the rate of economic growth, but also by using more appropriate estimation techniques. The outcome of a series of panel and structural break tests examining the accession process of five recent members to the Union generally show improved rates of productivity growth and convergence to EU standards. We then draw from the experience of these recent members to derive implications for the first-round EU candidate countries. Subsequent tests on the first-round candidate countries find a high level of heterogeneity in growth rates, and a fast-paced convergence to EU standards.
Dietary Adequacies among South African Adults in Rural KwaZulu-Natal

Background Food quality, determined by micronutrient content, is a stronger determinant of nutritional status than food quantity. Health concerns resulting from the co-existence of over-nutrition and under-nutrition in low income populations in South Africa have been fully recognized in the last two decades. This study aimed to further investigate dietary adequacy amongst adults in rural KwaZulu-Natal, by determining daily energy and nutrient intakes, and identifying the degree of satisfaction of dietary requirements. Methods Cross-sectional study assessing dietary adequacy from 24-hour dietary recalls of randomly selected 136 adults in Empangeni, KwaZulu-Natal, South Africa. Results Results are presented for men (n = 52) and women (n = 84) 19–50 and >50 years old. Mean energy intake was greatest in women >50 years (2852 kcal/day) and exceeded Dietary Reference Intake’s for both men and women, regardless of age. Mean daily energy intake from carbohydrates was 69% for men and 67% for women, above the Dietary Reference Intake range of 45–65%. Sodium was also consumed in excess, and the Dietary Reference Intakes of vitamins A, B12, C, D, and E, calcium, zinc and pantothenic acid were not met by the majority of the population. Conclusion Despite mandatory fortification of staple South African foods, micronutrient inadequacies are evident among adults in rural South African communities. Given the excess caloric intake and the rising prevalence of obesity and other non-communicable diseases in South Africa, a focus on diet quality may be a more effective approach to influence micronutrient status than a focus on diet quantity.