Miracle-dz/UniFAR-FTUs huggingface dataset:
Spinopelvic Changes Based on the Simplified SRS-Schwab Adult Spinal Deformity Classification: Relationships With Disability and Health-Related Quality of Life in Adult Patients With Prolonged Degenerative Spinal Disorders

Study Design. Cross-sectional, observational study. Objective. To study the occurrence of sagittal malalignment, the adaptability of a simplified sagittal modifiers grading of the Scoliosis Research Society (SRS)-Schwab adult spinal deformity (ASD) classification, and the deformity-specific SRS questionnaire version 30 (SRS-30) in an unselected adult cohort with symptomatic degenerative spinal disorders. Summary of Background Data. The sagittal modifiers of the SRS-Schwab ASD classification correlate with health-related quality of life (HRQoL) measures in patients with ASD. The deformities and disabilities caused by sagittal malalignment in patients with common degenerative spinal disorders of multiple etiologies are rarely studied. A simplified and categorizing version of the SRS-Schwab ASD classification in relation to the Oswestry Disability Index (ODI) and the SRS-30 outcomes has not yet been developed. Methods. We recruited 874 consecutive patients with degenerative spinal disorders between March 2013 and February 2014. Full spine radiographs were taken and the patients divided into sagittal deformity severity groups: mild or none, moderate, and marked deformity. Participants completed the ODI, SRS-30, and a general health questionnaire. Results. We included 637 patients in the analysis. The severity of sagittal deformity was mild or none in 407 (63.9%) patients, moderate in 159 (25.0%), and marked in 71 (11.1%). Linearity across the modifier grades and deformity classes was found for ODI total score (P = 0.033), and the function/activity (P = 0.004) and self-image/appearance (P = 0.030) domains of the SRS-30. Age, body mass index, duration of symptoms, and the use of painkillers increased while physical activity, working, and educational status decreased significantly with deformity severity. Conclusion. Sagittal spinopelvic malalignment is significantly related to deterioration of the ODI and the SRS-30 in symptomatic adults with degenerative spinal disorders. The SRS-Schwab classification sagittal modifiers categorized into three groups is a practical tool to detect various clinically significant grades of deformity in a cohort with no recognized ASD. Level of Evidence: 3
Self-Perceived Mate Value, Facial Attractiveness, and Mate Preferences: Do Desirable Men Want It All?

Ten years ago, Buss and Shackelford demonstrated that high mate value (i.e., physically attractive) women held more discerning mate preferences relative to lower mate value women. Since then, researchers have begun to consider the equally important role of men’s sexual selectivity in human mate choice. Yet, little research has focused on whether high mate value men are similarly choosy in their mate preferences. In a sample of 139 undergraduate men, relationships between self-perceived mate value as well as female-rated facial attractiveness were examined in relation to men’s expressed mate preferences. Results showed that self-perceived mate value was unrelated to men’s facial attractiveness as rated by women. Men who believed they were of high mate value were more likely than lower mate value men to prefer to marry at a younger age; to have a spouse who was younger than them; and to have a partner who was sociable, ambitious, high in social status, with good financial prospects, a desire for children, health, good looks, and mutual attraction. Objective male facial attractiveness was generally unrelated to heightened mate preferences, with the exception of heightened preference for similar religious background and good physical health. Findings suggest that men who perceive themselves as high in overall mate value are selective in their mate choice in a manner similar to high mate value women.
Mycobacterium tuberculosis Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) Functions as a Receptor for Human Lactoferrin

Iron is crucial for the survival of living cells, particularly the human pathogen Mycobacterium tuberculosis (M.tb) which uses multiple strategies to acquire and store iron. M.tb synthesizes high affinity iron chelators (siderophores), these extract iron from host iron carrier proteins such as transferrin (Tf) and lactoferrin (Lf). Recent studies have revealed that M.tb may also relocate several housekeeping proteins to the cell surface for capture and internalization of host iron carrier protein transferrin. One of the identified receptors is the glycolytic enzyme Glyceraldehyde-3-phosphate dehydrogenase (GAPDH). This conserved multifunctional protein has been identified as a virulence factor in several other bacterial species. Considering the close structural and functional homology between the two major human iron carrier proteins (Tf and Lf) and the fact that Lf is abundantly present in lung fluid (unlike Tf which is present in plasma), we evaluated whether GAPDH also functions as a dual receptor for Lf. The current study demonstrates that human Lf is sequestered at the bacterial surface by GAPDH. The affinity of Lf-GAPDH (31.7 ± 1.68 nM) is higher as compared to Tf-GAPDH (160 ± 24 nM). Two GAPDH mutants were analyzed for their enzymatic activity and interaction with Lf. Lastly, the present computational studies offer the first significant insights for the 3D structure of monomers and assembled tetramer with the associated co-factor NAD+. Sequence analysis and structural modeling identified the surface exposed, evolutionarily conserved and functional residues and predicted the effect of mutagenesis on GAPDH.
From Tradition to Modernity: Economic Growth in a Small World

This paper introduces the Small World model into the theory of economic growth and investigates how increasing economic integration affects firm size and efficiency, norm enforcement, and aggregate economic performance. When economic integration is low and local connectivity is high, informal norms control entrepreneurial behavior and more integration mainly improves search for investment opportunities. At a higher level of economic integration neighborhood enforcement deteriorates and formal institutions are needed to keep entrepreneurs in check. A gradual take-off to perpetual growth is explained by a feedback effect from investment to the formation of long-distance links and the diffusion of knowledge. If formal institutions are weak, however, the economy does not take off but stagnates at an intermediate income level. Structurally, the equilibrium of stagnation differs from balanced growth by the presence of many small firms with low productivity.
Changes in neurotic personality profile associated with reduction of suicidal ideation in patients who underwent psychotherapy in the day hospital for the treatment of neurotic and behavioral disorders.

AIM Analysis of associations between changes in neurotic personality profile and reductionof suicidal ideation (SI) - or lack of such reduction - defined as its elimination or reduction of its intensity in patients who underwent a course of intensive psychotherapy conducted in integrative approach with predominance of psychodynamic approach. METHODS Symptom Checklist KO"O", Neurotic Personality Questionnaire KON-2006 and Life Inventory completed by 461 women and 219 men treated due to neurotic, behavioral or personality disorders in a day hospital between 2005-2013. During the qualification for the therapy 134 women and 80 men reported SI, of whom 84.3% and 77.5% respectively improved. RESULTS Patients who improved in terms of SI obtained significantly greater reduction of global neurotic personality disintegration (neuroticism) than others (p<0.0005 in women and p=0.015 in men). Associations were found between improvement in terms of SI and greater reduction of many neurotic personality traits (p<0.05) in both genders: Negative self-esteem, Impulsiveness, Sense of alienation, Demobilization, Difficulties in emotional relations, Lack of vitality, Sense of lack of control, Sense of guilt, Difficulties in interpersonal relations, Sense of being in danger, Exaltation, Ponderings; and only in women: Feeling of being dependent on the Environment, Asthenia, Difficulties with decision making, Conviction of own resourcelessness in life, Deficit in internal locus of control and Imagination. indulging in fiction. CONCLUSIONS The results confirm effectiveness of intensive psychotherapy as a treatment method that leads to comprehensive improvement encompassing reduction of neurotic personality disorders (neuroticism) and of majority of neurotic personality traits, as well as SI reduction. The revealed associations weigh in favor of hypothesis on neuroticism as SI predisposing factor in patients with neurotic, behavioral and personality disorders.
Attentional Factorization Machines: Learning the Weight of Feature Interactions via Attention Networks

Factorization Machines (FMs) are a supervised learning approach that enhances the linear regression model by incorporating the second-order feature interactions. Despite effectiveness, FM can be hindered by its modelling of all feature interactions with the same weight, as not all feature interactions are equally useful and predictive. For example, the interactions with useless features may even introduce noises and adversely degrade the performance. In this work, we improve FM by discriminating the importance of different feature interactions. We propose a novel model named Attentional Factorization Machine (AFM), which learns the importance of each feature interaction from data via a neural attention network. Extensive experiments on two real-world datasets demonstrate the effectiveness of AFM. Empirically, it is shown on regression task AFM betters FM with a $8.6\%$ relative improvement, and consistently outperforms the state-of-the-art deep learning methods Wide&Deep and DeepCross with a much simpler structure and fewer model parameters. Our implementation of AFM is publicly available at: this https URL
Tomographic and anatomical study of the orbit and nasolacrimal duct in capybaras (Hydrochoerus hydrochaeris—Linnaeus, 1766)

The objective of this study was to describe the reference values of cranial measurements of capybaras, correlating the ocular orbit with the nasolacrimal duct. The documentation of its results can contribute to standardizing characteristics of anatomical normality and favouring the correct diagnosis and treatment of changes. The capybara carcasses, maintained by freezing, were distributed in two groups (G) designated GA (n = 12) adult animals (A) and GY (n = 13) for young animals (Y). All subjects underwent dacryocystography examination by computed tomography (CT) and cranial measurements. Descriptive analyses of cranial and nasolacrimal duct measurements and statistical analysis of the Pearson correlation with the variable weight were performed. In GA, there was no correlation between the nasolacrimal and cranial duct measurements. However, in the GY, a correlation was verified with facial length (r = .6233), facial width (r = .5771), cranial height (r = .6981), cranial length (r = .7116), total right length (r = .7517) and left length (r = .7999). Thus, in the young animals, cranial length measurements were strongly correlated with nasolacrimal duct lengths. However, this biological behaviour was not observed in adults, demonstrating stability in development. The capybara's ocular orbit was found to be circular and incomplete, with developed zygomatic process of the maxilla. CT dacryocystography is indicated to evaluate the nasolacrimal canal pathway in capybaras, emphasizing the importance of normal anatomical study to aid in treating animals affected by diseases.
The Effects of Dynamical Rates on Species Coexistence in a Variable Environment: The Paradox of the Plankton Revisited

Hutchinson’s famous hypothesis for the “paradox of the plankton” has been widely accepted, but critical aspects have remained unchallenged. Hutchinson argued that environmental fluctuations would promote coexistence when the timescale for environmental change is comparable to the timescale for competitive exclusion. Using a consumer-resource model, we do find that timescales of processes are important. However, it is not the time to exclusion that must be compared with the time for environmental change but the time for resource depletion. Fast resource depletion, when resource consumption is favored for different species at different times, strongly promotes coexistence. The time for exclusion is independent of the rate of resource depletion. Therefore, the widely believed predictions of Hutchinson are misleading. Fast resource depletion, as determined by environmental conditions, ensures strong coupling of environmental processes and competition, which leads to enhancement over time of intraspecific competition relative to interspecific competition as environmental shifts favor different species at different times. This critical coupling is measured by the covariance between environment and competition. Changes in this quantity as densities change determine the stability of coexistence and provide the key to rigorous analysis, both theoretically and empirically, of coexistence in a variable environment. These ideas apply broadly to diversity maintenance in variable environments whether the issue is species diversity or genetic diversity and competition or apparent competition.
Investigating capillary electrophoresis‐mass spectrometry for the analysis of common post‐translational modifications

Capillary electrophoresis coupled to mass spectrometry is a very efficient analytical method for the analysis of post‐translational modifications because of its high separation efficiency and high detection sensitivity. Here we applied CE‐MS using three differently coated separation capillaries for in‐depth analysis of a set of 70 synthetic post‐translationally modified peptides (including phosphorylation, acetylation, methylation, and nitration). We evaluated the results in terms of peptide detection and separation characteristics and found that the use of a neutrally coated capillary resulted in highest overall signal intensity of singly modified peptides. In contrast, the use of a bare‐fused silica capillary was superior in the identification of multi‐phosphorylated peptides (12 out of 15 were identified). Fast separations of approximately 12 min could be achieved using a positively coated capillary, however, at the cost of separation efficiency. A comparison to nanoLC‐MS revealed that multi‐phosphorylated peptides interact with the RP material very poorly so that these peptides were either washed out or elute as very broad peaks from the nano column which results in a reduced peptide identification rate (7 out of 15). Moreover, the methods applied were found to be very well suited for the analysis of the acetylated, nitrated and methylated peptides. All 36 synthetic peptides, which exhibit one of those modifications, could be identified regardless of the method applied. As a final step in this study and as a proof of principle, the phosphoproteome enriched from PC‐12 pheochromocytoma cells was analyzed by CE‐MS resulting in 5686 identified and 4088 quantified phosphopeptides. We compared the characterized analytes to those identified by a nanoLC‐MS proteomics study and found that less than one third of the phosphopeptides were identical, which demonstrates the benefit by combining different approaches quite impressively.
Computed tomography angiography study of variations of the celiac trunk and hepatic artery in 100 patients

Objective To describe the main anatomical variations of the celiac trunk and the hepatic artery at their origins. Materials and Methods This was a prospective analysis of 100 consecutive computed tomography angiography studies of the abdomen performed during a one-year period. The findings were stratified according to classification systems devised by Sureka et al. and Michels. Results The celiac trunk was "normal" (i.e., the hepatogastrosplenic trunk and superior mesenteric artery originating separately from the abdominal aorta) in 43 patients. In our sample, we identified four types of variations of the celiac trunk. Regarding the hepatic artery, a normal anatomical pattern (i.e., the proper hepatic artery being a continuation of the common hepatic artery and bifurcating into the right and left hepatic arteries) was seen in 82 patients. We observed six types of variations of the hepatic artery. Conclusion We found rates of variations of the hepatic artery that are different from those reported in the literature. Our findings underscore the need for proper knowledge and awareness of these anatomical variations, which can facilitate their recognition and inform decisions regarding the planning of surgical procedures, in order to avoid iatrogenic intraoperative injuries, which could lead to complications.
Harmonic Contrast-Enhanced Endoscopic Ultrasonography for the Guidance of Fine-Needle Aspiration in Solid Pancreatic Masses

Abstract Purpose The global accuracy of fine-needle aspiration guided by endoscopic ultrasound (EUS-FNA) for pancreatic adenocarcinoma is about 85 %. The use of contrast agents during EUS to highlight vessels and the necrotic parts of pancreatic masses may improve biopsy guidance. Our aim was to assess whether the guidance of FNA by harmonic contrast-enhanced endoscopic ultrasound (CH-EUS) would increase diagnostic accuracy relative to conventional EUS-FNA in the same pancreatic masses. Patients and Methods In a prospective study, EUS-FNA was performed in patients with pancreatic masses on CT scan, followed by harmonic CH-EUS using SonoVue. A second cluster of CH-EUS-FNA was performed on contrast-enhanced images. The final diagnosis was based on the results of EUS-FNA and surgery, or the findings after 12 months’ follow-up. Results The final diagnosis was adenocarcinoma (n = 35), chronic pancreatitis (n = 10), or other (n = 6). The diagnostic accuracy based on core histology was 78.4 % for EUS-FNA and 86.5 % for CH-EUS-FNA (p = 0.35). The accuracy increased to 94 % when the two methods’ results were combined. The two false-negative EUS-FNA cases were correctly appreciated by CH-EUS. Neither core histology size nor the presence of necrosis was significant for the true-positive diagnosis of malignancy. Conclusion CH-EUS-FNA had an insignificant incremental effect on diagnostic accuracy compared with conventional EUS-FNA in our small group. The presence of necrosis did not influence the results of CEUS-FNA. Qualitative assessment of the contrast uptake within the lesion was useful in false-negative EUS-FNA cases.
Replication of Extended Lifespan Phenotype in Mice with Deletion of Insulin Receptor Substrate 1

We previously reported that global deletion of insulin receptor substrate protein 1 (Irs1) extends lifespan and increases resistance to several age-related pathologies in female mice. However, no effect on lifespan was observed in male Irs1 null mice. We suggested at the time that the lack of any effect in males might have been due to a sample size issue. While such lifespan studies are essential to our understanding of the aging process, they are generally based on survival curves derived from single experiments, primarily due to time and economic constraints. Consequently, the robustness of such findings as a basis for further investigation has been questioned. We have therefore measured lifespan in a second, separate cohort of Irs1 null female mice, and show that, consistent with our previous finding, global deletion of Irs1 significantly extends lifespan in female mice. In addition, an augmented and completed study demonstrates lifespan extension in male Irs1 null mice. Therefore, we show that reduced IRS1-dependent signalling is a robust mechanism through which mammalian lifespan can be modulated.
Effect of Co-Production of Renewable Biomaterials on the Performance of Asphalt Binder in Macro and Micro Perspectives

Conventional asphalt binder derived from the petroleum refining process is widely used in pavement engineering. However, asphalt binder is a non-renewable material. Therefore, the use of a co-production of renewable bio-oil as a modifier for petroleum asphalt has recently been getting more attention in the pavement field due to its renewability and its optimization for conventional petroleum-based asphalt binder. Significant research efforts have been done that mainly focus on the mechanical properties of bio-asphalt binder. However, there is still a lack of studies describing the effects of the co-production on performance of asphalt binders from a micro-scale perspective to better understand the fundamental modification mechanism. In this study, a reasonable molecular structure for the co-production of renewable bio-oils is created based on previous research findings and the observed functional groups from Fourier-transform infrared spectroscopy tests, which are fundamental and critical for establishing the molecular model of bio-asphalt binder with various biomaterials contents. Molecular simulation shows that the increase of biomaterial content causes the decrease of cohesion energy density, which can be related to the observed decrease of dynamic modulus. Additionally, a parameter of Flexibility Index is employed to characterize the ability of asphalt binder to resist deformation under oscillatory loading accurately.
Studying young people’ views on deployment of renewable energy sources in Iran through the lenses of Social Cognitive Theory

Renewable energy sources (RES) have potentials to address goals of climate change mitigation at the global level. Iran has abundant RES potentials and investment into renewable energy sources can contribute to its socio-economic development and to diversification of its energy mix. Economic and technical capacities but also human factors, such as stakeholders’ views, public and social acceptance, as well as willingness to use RES, willingness to pay for their deployment and to participate in decision-making processes on energy transition, are crucial factors for deployment of RES at scale. These human factors impact development and implementation of energy transition at the national and local governance levels. Deployment of new technology and energy transition can lead to conflicting views, believes and risks perceptions among involved stakeholders but also among people affected by deployment of new technology infrastructure deployment. To be sustainable and acceptable by all social groups, such process should be based on understanding of positions of different stakeholders and development of compromise solutions. It is crucial to understand the views of young people on deployment of RES as young people represent a significant share of population and are future decision makers. Their support and willingness to use RES will be a significant driver for RES deployment in short and medium term. Based on socio cognitive theory this paper examines the patters of behavior of young adults in relation to energy use. The results show positive influence of self-rewarding to encourage young adults to participate in energy transition. Another important driver is expectation of social outcome, which involves existing social norms in the community. Trust to the source of information is another important driver and the level of information about RES has an important influence on the willingness to use them.