Miracle-dz/UniFAR-FTUs huggingface dataset:
Efficacy of Anakinra for Various Types of Crystal-Induced Arthritis in Complex Hospitalized Patients: A Case Series and Review of the Literature

Background. There are few data on anakinra use after failure of conventional medications for crystal-induced peripheral arthritis and/or crowned dens syndrome among complex hospitalized patients. Methods. We retrospectively analyzed the outcome of six patients affected with subacute crystal-induced arthritis who had received anakinra in second or third line therapy, including three patients with crowned dens syndrome and three others with gouty arthritis. Patients' comorbidities, reasons for anakinra use and associated drugs, and outcomes were recorded. Results. All patients presented with elevated inflammatory syndrome, systemic symptoms with poly/oligoarthritis. Except for absolute contraindications, all patients were previously treated with full or decreased dose of NSAID, colchicine, and/or glucocorticoids, with unsatisfactory response. All three gouty patients exhibited complete responses in all acute involvements under anakinra within 3 to 5 days, including one of them who needed the reintroduction of colchicine treatment that was previously unsuccessful. Crowned dens syndrome patients, including two with pseudogout and one with subacute hydroxyapatite deposition disease, needed 9 to 11 days to achieve complete response. Tolerance to anakinra was good. Conclusion. In case series of complex hospitalized patients, anakinra showed good activity in crowned dens syndrome and associated crystal-induced peripheral arthritis, with longer treatment duration than in gouty arthritis.
Cortex Objective Metamemory Testing Captures Awareness of Deficit in Alzheimer ’ s Disease

For reasons that remain unknown, there is marked inter-person variability in awareness of episodic memory loss in patients with Alzheimer’s disease (AD). Existing research designs, primarily subjective in nature, have been at a relative disadvantage for evaluating disordered metamemory and its relation to the clinical and neuropathological heterogeneity of AD, as well as its prognosis for various disease outcomes. The current study sought to establish an objective means of evaluating metamemory in AD by modifying traditional metacognitive paradigms in which participants are asked to make predictions regarding their own memory performance. Variables derived from this measure were analyzed in relation to clinically rated awareness for memory loss. As predicted, a range of awareness levels existed across patients with mild to moderate AD (n = 24) and clinical ratings of awareness were significantly associated with verbal episodic memory monitoring (r = .46, p = .03). Further, patients who were rated as aware of their memory loss remained well calibrated over the course of the task whereas those rated as relatively unaware grew over-confident in their predictions F (1, 33) = 4.19, p = . 02. Findings suggest that over-confidence may be related to impaired online error recognition and compromised use of metamemory strategies such as the Memory for Past Test heuristic. Importantly, clinically rated awareness did not vary as a function of demographic variables, global cognition, or verbal memory. However, participants characterized as relatively unaware were impaired on a nonverbal memory task as compared to aware participants, F (1, 20) = 6.98, p = . 02. The current study provides preliminary support for the use of a recognition-based verbal episodic memory monitoring task as a quantitative measure of awareness for memory loss in AD, and offers insight into the manner in which metamemory breaks down. Discrepancies in nonverbal memory across the two awareness groups provide partial support for the idea that metamemory variability in AD may be related to the neuroanatomic presentation of the disease, with disordered awareness potentially reflective of a critical level of right hemisphere involvement.
Topical formulations of novel angiostatic steroids inhibit rabbit corneal neovascularization.

PURPOSE To evaluate the antiangiogenic potential of topical ophthalmic formulations of the novel angiostatic steroids AL-3789 and AL-4940, using a rabbit model of corneal neovascularization. METHODS Neovascularization was induced in the rabbit cornea by surgical implantation of a standard ethylene vinyl acetate copolymer (Elvax-40) pellet containing 1 microg lipopolysaccharide. Coded formulations of the control vehicle or the following test agents were administered in prevention and intervention treatment protocols: 1% formulations of AL-3789, AL-4940, and cortisol acetate as a positive drug control. Three doses of AL-3789 (0.01%, 0.1%, and 1%) were also evaluated in a prevention treatment protocol. Corneal responses were monitored throughout a 2-week treatment period, and 1 week after the last treatment dose. Observations included quantitative measurement of the area of new blood vessel growth and qualitative assessment of cellular infiltrate and edema. All treatments and observations were performed in a double-masked manner. RESULTS All tested formulations, except the vehicle and the 0.01% AL-3789 preparation, significantly inhibited corneal neovascularization and other lipopolysaccharide-induced responses in the various treatment protocols employed. AL-4940, the free alcohol form of AL-3789, was slightly less effective than cortisol acetate or AL-3789. The extent of inhibition of the angiogenic response by the 1% and 0.1% AL-3789 suspensions ranged from 76% to 100% 1 week after the last treatment. CONCLUSIONS The antiangiogenic steroid AL-3789 may be a therapeutically useful angiostatic agent for corneal neovascularization and potentially could be effective in other ocular neovascular diseases.
Neuromuscular and endocrine responses of elite players during an Australian rules football season.

PURPOSE To examine variations in neuromuscular and hormonal status and their relationship to performance throughout a season of elite Australian Rules Football (ARF). METHODS Fifteen elite ARF players performed a single jump (CMJ1) and 5 repeated countermovement jumps (CMJ5), and provided saliva samples for the analysis of cortisol (C) and testosterone (T) before the season commenced (Pre) and during the 22-match season. Magnitudes of effects were reported with the effect size (ES) statistic. Correlations were performed to analyze relationships between assessment variables and match time, training load, and performance. RESULTS CMJ1Flight time:Contraction time was substantially reduced on 60% of measurement occasions. Magnitudes of change compared with Pre ranged from 1.0+/-7.4% (ES 0.04+/-0.29) to -17.1+/-21.8% (ES -0.77+/-0.81). Cortisol was substantially lower (up to -40+/-14.1%, ES of -2.17+/-0.56) than Pre in all but one comparison. Testosterone response was varied, whereas T:C increased substantially on 70% of occasions, with increases to 92.7+/-27.8% (ES 2.03+/-0.76). CMJ1Flight time:Contraction time (r=.24+/-0.13) and C displayed (r=-0.16+/-0.1) small correlations with performance. CONCLUSION The response of CMJ1Flight time:Contraction time suggests periods of neuromuscular fatigue. Change in T:C indicates subjects were unlikely to have been in a catabolic state during the season. Increase in C compared with Pre had a small negative correlation with performance. Both CMJ1Flight time:Contraction time and C may be useful variables for monitoring responses to training and competition in elite ARF athletes.
Seismic Constraints on a Double‐Layered Asymmetric Whole‐Mantle Plume Beneath Hawai‘i

AbstrAct It is generally accepted that mantle plumes are responsible for hotspot chains and as such provide insight to mantle convection processes. Among all the hotspots, the Hawaiian chain is a characteristic example that has been extensively explored. However, many questions remain. If a plume does exist beneath the Hawaiian chain, what is the shape, size, and orientation of the plume conduit? To what extent can the seismic structure of the plume be mapped? Can we see a continuous plume conduit extending from the lower to the upper mantle? At what depth do melting processes occur? Here, we combine constraints from three data sets (body waves, ballistic surface waves, and ambient noise) to create 3D images of the velocity structure beneath the Hawaiian Islands from a depth of ~800 km to the surface. We use data from the Hawaiian Plume Lithosphere Undersea Melt Experiment (PLUME), which was a network of four‐component broadband ocean bottom seismometers that had a network aperture of ~1000 km. Our multiphase 3D model results indicate there is a large deep‐rooted low‐velocity anomaly rising from the lower mantle. At transition zone depths the conduit is located to the southeast of Hawai'i. A 2% S‐wave anomaly is observed in the core of the plume conduit around 700 km depth, which, once corrected for damping effects, suggests a 200–250°C temperature anomaly assuming a thermal plume. In the upper mantle, there is a horizontal plume " pancake " at shallow depths beneath the oceanic lithosphere, and there is also a second horizontal low‐ velocity layer in the 250 to 410 km depth range beneath the island chain. This second layer is only revealed after surface wave phase velocity data are incorporated into the inversion scheme to improve the constraints on the structure in the upper ~200 km. We suggest this feature is a deep eclogite pool (DEP), an interpretation consistent with geodynamic modeling [Ballmer et al., 2013]. The model also shows reduced lithospheric velocities compared to the typical ~100 Myr old lithosphere, implying lithospheric rejuvenation by the plume. In addition, a shallow (~20 km) low‐velocity anomaly is observed southeast of the Island of Hawai'i. This suggests a newly modified lithosphere, as might be expected in the location of an emerging new island in the Hawaiian chain. The Hawaiian Islands are an ideal place to study intra-plate hotspots. Many researchers consider it to be a case example of a deep‐rooted whole‐mantle …
Array-based evolution of DNA aptamers allows modelling of an explicit sequence-fitness landscape

Mapping the landscape of possible macromolecular polymer sequences to their fitness in performing biological functions is a challenge across the biosciences. A paradigm is the case of aptamers, nucleic acids that can be selected to bind particular target molecules. We have characterized the sequence-fitness landscape for aptamers binding allophycocyanin (APC) protein via a novel Closed Loop Aptameric Directed Evolution (CLADE) approach. In contrast to the conventional SELEX methodology, selection and mutation of aptamer sequences was carried out in silico, with explicit fitness assays for 44 131 aptamers of known sequence using DNA microarrays in vitro. We capture the landscape using a predictive machine learning model linking sequence features and function and validate this model using 5500 entirely separate test sequences, which give a very high observed versus predicted correlation of 0.87. This approach reveals a complex sequence-fitness mapping, and hypotheses for the physical basis of aptameric binding; it also enables rapid design of novel aptamers with desired binding properties. We demonstrate an extension to the approach by incorporating prior knowledge into CLADE, resulting in some of the tightest binding sequences.
MAGIC upper limits on the high energy emission from GRBs

During its cycle-1 observation period, between April 2005 and March 2006, the MAGIC telescope was able to observe nine Gamma Ray Burst (GRB) events since their early beginning. Other observations were performed during the following months in the cycle-2 observation period. The observations, with an energy threshold spanning from 80 to 200 GeV, did not reveal any gamma ray emission. The computed upper limits are compatible with a power law extrapolation, where intrinsic fluxes are evaluated taking into account the attenuation due to the scattering in the metagalactic radiation field.
Relationship between cobalamin deficiency and delirium in elderly patients undergoing cardiac surgery

Background Delirium is common after cardiac surgery and is independently associated with increased morbidity, mortality, prolonged hospital stays, and higher costs. Cobalamin (vitamin B12) deficiency is a common cause of neuropsychiatric symptoms and affects up to 40% of elderly people. The relationship between cobalamin deficiency and the occurrence of delirium after cardiac surgery has not been examined in previous studies. We examined the relationship between cobalamin deficiency and delirium in elderly patients undergoing coronary artery bypass grafting (CABG) surgery. Material and methods A total of 100 patients with cobalamin deficiency undergoing CABG were enrolled in this retrospective study. Control group comprised 100 patients without cobalamin deficiency undergoing CABG. Patients aged 65 years or over were included. Diagnosis of delirium was made using Intensive Care Delirium Screening Checklist. Delirium severity was measured using the Delirium Rating Scale-revised-98. Results Patients with cobalamin deficiency had a significantly higher incidence of delirium (42% vs 26%; P=0.017) and higher delirium severity scores (16.5±2.9 vs 15.03±2.48; P=0.034) than patients without cobalamin deficiency. Cobalamin levels were significantly lower in patients with delirium than patients without delirium (P=0.004). Delirium severity score showed a moderate correlation with cobalamin levels (ρ=−0.27; P=0.024). Logistic regression analysis demonstrated that cobalamin deficiency was independently associated with postoperative delirium (OR 1.93, 95% CI 1.03–3.6, P=0.038). Conclusion The results of our study suggest that cobalamin deficiency may be associated with increased risk of delirium in patients undergoing CABG. In addition, we found that preoperative cobalamin levels were associated with the severity of delirium. This report highlights the importance of investigation for cobalamin deficiency in patients undergoing cardiac surgery, especially in the elderly.
Optimising Ambient Setting Bayer Derived Fly Ash Geopolymers

The Bayer process utilises high concentrations of caustic and elevated temperature to liberate alumina from bauxite, for the production of aluminium and other chemicals. Within Australia, this process results in 40 million tonnes of mineral residues (Red mud) each year. Over the same period, the energy production sector will produce 14 million tonnes of coal combustion products (Fly ash). Both industrial residues require impoundment storage, yet combining some of these components can produce geopolymers, an alternative to cement. Geopolymers derived from Bayer liquor and fly ash have been made successfully with a compressive strength in excess of 40 MPa after oven curing. However, any product from these industries would require large volume applications with robust operational conditions to maximise utilisation. To facilitate potential unconfined large-scale production, Bayer derived fly ash geopolymers have been optimised to achieve ambient curing. Fly ash from two different power stations have been successfully trialled showing the versatility of the Bayer liquor-ash combination for making geopolymers.
AVHRR‐NDVI‐based crop coefficients for analyzing long‐term trends in evapotranspiration in relation to changing climate in the U.S. High Plains

Studies in regions of extensive irrigation practices have revealed a significant influence of evaporative cooling on regional temperatures as a result of surface energy redistribution during evaporation. In the U.S. High Plains, maximum temperatures during the last quarter of the 20th century have been decreasing. We investigated the trends in evapotranspiration (ET or latent heat) fluxes originating from increasing irrigation practices in the High Plains region from 1981 to 2008. We estimated actual ET (ETc) over the entire High Plains from the spatial crop coefficients (Kc) and spatial reference (potential) ET (ETref). We proposed and validated a global linear relation between Kc and advanced very high resolution radiometer‐based normalized difference vegetation index. Our results show an increase in ETc trends over the region in the last three decades. The study shows that the increase in ETc flux was not in principal from increased atmospheric evaporative demand. Rather, the increase in ETc was due to significant increase in irrigated surfaces. The increase in ETc fluxes is likely a manifestation of increased redistribution of surface energy into latent heat and less partitioning into the sensible heat. We investigated the evolution of full canopy cover vegetation (normalized difference vegetation index >0.70) in relation to the maximum temperature anomalies during the study period. Results revealed a significant negative correlation between the two variables. These results appear to demonstrate that there is a regional evaporative cooling signal due to extensive irrigation practices, which impacts regional temperatures during the summer seasons.
Patterns of Innovation in Internet Banking

This paper analyses the adoption and implementation of Internet banking on the basis of theories of organizational and information system innovation. It is one of the first studies examining innovation pattern and performance at the firm level in the service sector. Using survey data from 278 Danish, Finnish, Norwegian, and Swedish banks, it is shown how these banks – some of which are among the world leaders in the use of new banking technology – respond to the challenge of Web technologies. The different adoption patterns of the banks are analyzed using structural equation modeling. The results show that an early adoption of sophisticated, integrated Internet-banking solutions is associated with market orientation, inter-firm cooperation in joint ventures, and willingness to cannibalize older investments. The results also indicate that attractive Web sites depend on management support and line-crossing participation in the process of implementation. As for performance, there is argued against simple technological instrumentality and against the prediction that small late adopters are outperformed by large first movers.
Competition and facilitation structure plant communities under nurse tree canopies in extremely stressful environments

Abstract Nurse plant facilitation in stressful environments can produce an environment with relatively low stress under its canopy. These nurse plants may produce the conditions promoting intense competition between coexisting species under the canopy, and canopies may establish stress gradients, where stress increases toward the edge of the canopy. Competition and facilitation on these stress gradients may control species distributions in the communities under canopies. We tested the following predictions: (1) interactions between understory species shift from competition to facilitation in habitats experiencing increasing stress from the center to the edge of canopy of a nurse plant, and (2) species distributions in understory communities are controlled by competitive interactions at the center of canopy, and facilitation at the edge of the canopy. We tested these predictions using a neighbor removal experiment under nurse trees growing in arid environments. Established individuals of each of four of the most common herbaceous species in the understory were used in the experiment. Two species were more frequent in the center of the canopy, and two species were more frequent at the edge of the canopy. Established individuals of each species were subjected to neighbor removal or control treatments in both canopy center and edge habitats. We found a shift from competitive to facilitative interactions from the center to the edge of the canopy. The shift in the effect of neighbors on the target species can help to explain species distributions in these canopies. Canopy‐dominant species only perform well in the presence of neighbors in the edge microhabitat. Competition from canopy‐dominant species can also limit the performance of edge‐dominant species in the canopy microhabitat. The shift from competition to facilitation under nurse plant canopies can structure the understory communities in extremely stressful environments.
Disambiguation of social polarization concepts and measures

ABSTRACT This article distinguishes nine senses of polarization and provides formal measures for each one to refine the methodology used to describe polarization in distributions of attitudes. Each distinct concept is explained through a definition, formal measures, examples, and references. We then apply these measures to GSS data regarding political views, opinions on abortion, and religiosity—topics described as revealing social polarization. Previous breakdowns of polarization include domain-specific assumptions and focus on a subset of the distribution’s features. This has conflated multiple, independent features of attitude distributions. The current work aims to extract the distinct senses of polarization and demonstrate that by becoming clearer on these distinctions we can better focus our efforts on substantive issues in social phenomena.
Survey of the effectiveness of stunning procedures used in Spanish pig abattoirs

Two pig abattoirs (A and B) equipped with an automated head-only and head-to-chest electrical stunning system, and two (C and D) equipped with a manual carbon dioxide stunning system, were evaluated to compare the effectiveness of stunning in a total of 10,454 pigs slaughtered under commercial conditions. In the abattoirs with the electrical stunning system, the percentage of animals that responded to a nose prick was significantly lower (P<0.05) in abattoir B, where a higher current intensity was used (P<0.05), than in abattoir A. No righting reflex was observed in the electrically stunned pigs. In the abattoirs with the carbon dioxide stunning system, the percentage of animals that responded to a nose prick and showed a righting reflex was significantly lower (P<0.05) in abattoir C, where the duration of the carbon dioxide cycle was longer and the interval between discharge from the system to sticking was shorter (P<0.05), than in D. Comparing the electrical and carbon dioxide stunning systems, the pigs stunned with carbon dioxide were significantly more responsive to a nose prick (P<0.05) and 25 per cent of them showed a righting reflex. Under the conditions of the study the fully automated head-only stunning with additional chest electrodes appeared to be more effective and less susceptible to incorrect handling than the manual carbon dioxide stunning system.