Miracle-dz/UniFAR-FTUs huggingface dataset:
Frequency distribution of Brugia malayi microfilariae in human populations

SUMMARY This study examines the effects of host age and sex on the frequency distribution of Brugia malayi infections in the human host. Microfilarial (mf) counts for a large data base on the epidemiology of brugian filariasis in Shertallai, Kerala, South India are analysed. Frequency distributions of microfilarial counts partitioned by age are successfully described by zero-truncated negative binomial distributions, fitted by maximum likelihood. This analysis provides estimates of the proportion of mf-positive individuals who are identified as negative due to sampling errors, allowing the construction of corrected mf age–prevalence curves, which indicate that the observed prevalence may under-estimate the true figures by between 18 and 47%. There is no evidence from these results for a decrease in the degree of over-dispersion of parasite frequency distributions with host age, such as might be produced by the acquired immunity to infection. This departure from the pattern in bancroftian filariasis (where there is evidence of such decreases in over-dispersion; Das et al. 1990) is discussed in terms of the long history of filariasis control (and consequently low infection prevalence) in Shertallai.
Identification of toxigenic Clostridium difficile by the polymerase chain reaction

Toxigenic strains of Clostridium difficile are causative agents of pseudomembranous colitis and antimicrobial agent-associated diarrhea and colitis. The toxigenicity is routinely assayed by using highly sensitive cell cultures. We used a simple and rapid polymerase chain reaction (PCR) assay to differentiate toxigenic and nontoxigenic strains of C. difficile. Two sets of oligonucleotide primer pairs derived from nonrepeating sequences of the toxin A gene were used to amplify 546- and 252-bp DNA fragments. A primer pair derived from repeating sequences of the toxin A gene was used to amplify a 1,266-bp DNA product. Amplified products were visualized by polyacrylamide gel electrophoresis followed by ethidium bromide staining. All 35 cytotoxic strains of C. difficile tested generated the expected amplified DNA. In contrast, none of the 26 noncytotoxic strains tested gave positive results. Although the toxins of C. difficile have been demonstrated to cross-react serologically with the toxins of Clostridium sordellii, we did not detect any amplified DNA in two cytotoxic strains or seven noncytotoxic strains of C. sordellii. PCR was negative in all 30 strains of 20 other Clostridium species. Southern hybridization of HindIII-digested genomic DNA by use of subgenomic probes showed a single hybridization band in toxigenic strains but not in nontoxigenic strains. PCR appears to be a sensitive and specific assay for the rapid identification of toxigenic C. difficile. Nontoxigenic C. difficile appeared to lack the C. difficile toxin A gene.
Human and social capital interplay among internationalizing SMEs

Purpose – This paper aims to provide an explanation for foreign small‐ and‐medium‐sized enterprise' (SMEs) internationalization results in China based on human and social capital interactions.Design/methodology/approach – The results of a qualitative comparative case study drawing on primary (interviews, observations) and secondary data (reports) are reported.Findings – The paper finds that human capital dimensions interact and influence social capital development for internationalization purposes. Different types of social capital can be developed (domestic or international) with different effects on internationalization. Similarities with Chinese guanxi practices are also established.Research limitations/implications – The present paper provides a starting‐point for further research in SME internationalization and entrepreneurs' characteristics in China regardless of cultural traits typically invoked: quantitative analysis, extension to a different context of internationalization or use of different des.
Building Competitiveness in Africa's Agriculture: A Guide to Value Chain Concepts and Applications

The development and business communities involved in the African agriculture and agribusiness sectors have recently experienced a strong resurgence of interest in promoting value chains as an approach that can help design interventions geared to add value, lower transaction costs, diversify rural economies, and contribute to increasing rural household incomes in Sub-Saharan Africa (SSA) countries. Enhancing value chain competitiveness is increasingly recognized as an effective approach to generating growth and reducing the rural poverty prevalent in the region. This is a welcome development for practitioners who have long been convinced of the need to look differently at agriculture not just as a means of survival, but as smaller or larger commercial businesses linked to domestic and global markets and of the need to identify and tap into new sources of potential growth and value addition in the sector. Hopefully, renewed engagement will lead to a substantial increase in the flow of financial resources and technical assistance devoted to supporting market-driven, competitive agro-enterprises and agricultural value chains throughout the African continent. However, there is danger that this renewed engagement may not last, or may even backfire, if the high expectations placed on promoting value chains are not met. Because the development literature is not clear about the concepts and methods relating to value chains, there is risk that sooner or later the benefits of the value chain approach will be overshadowed by unmet expectations. That in turn could cause the approach to be discarded categorically. Although there is no single way to mitigate such risks, this guide aims to offer practical advice and tools to businessmen, policy makers, representatives of farmer or trade organizations, and others who are engaged in SSA agro-enterprise and agribusiness development. This guide is particularly designed for those who want to know more about value chain based approaches, and how to use them in ways that can contribute to sound operational decisions and results for enterprise and industry development, as well as for policy making with respect to doing business, stimulating investment, and enhancing trade in the context of African agriculture.
Recovery of land costs: a land policy instrument missing in the Netherlands?

Until recently it has been usual in the Netherlands for local authorities to acquire land for development, to prepare it for building, and then make building lots available through sale or leasehold. In the 1990s housing production shifted from social housing to owner-occupied housing. Project developers became interested in the ownership of land as the key to build dwellings. These land purchases changed the context in which local authorities had to operate in the development of land. Instead of making arrangements for the recovery of costs via a public monopoly, local authorities now have to revert to a set of statutory instruments, or enter negotiations with market parties to come to an agreement on a voluntary contribution to development costs. In this contribution, we report the current state of the discussion in the Netherlands on the recovery of costs and we analyse various alternative instruments.
An Approach for Measuring Urban Deprivation Change: The Example of East Montréal and the Montréal Urban Community, 1986 – 96

The concept of urban deprivation has emerged as an important theme in urban geography and urban studies. In light of the significant problems and issues affecting cities in North America and Europe there is a growing need for researchers to acquire a better understanding of the process of urban social change. In this paper the author proposes a model of urban deprivation change and applies it with the use of census indicators to East Montréal, a section of the central city, and the Montréal Urban Community. The changing spatial structure and nature of urban deprivation is examined at the neighbourhood level in this study area over the period 1986 – 96. The author finds that urban deprivation is largely an economic problem, with declining conditions apparent throughout a large part of Montréal's central city and in several inner-suburban municipalities. The model, selection of indicators, and statistical techniques presented in this paper can be used as a guide for further research into urban deprivation change in other urban centres.
Degradation of Dispersants and Dispersed Oil

Chemical oil dispersants are proprietary mixtures of surfactants and solvents which are directly applied to a spill in order to reduce the natural attractive forces of the oil. When oil treated with dispersants is exposed to mixing energy, typically from wind and wave action, it is broken up into small droplets which may then become entrained in the water column (Li et al., 2009a; Li et al., 2009b; Li, 2008; Lunel, 1995). Many of these droplets are small enough to be neutrally buoyant, and therefore, advection and diffusion forces dilute the plume and transport the droplets far from the site of the original spill. As compared to a surface oil slick or larger and more buoyant physically dispersed oil droplets, these chemically dispersed droplets are much easier for oil-degrading bacteria to colonize and break down (Venosa and Holder, 2007; Venosa and Zhu, 2003). In addition, small droplets enhance dissolution of soluble and semi-volatile compounds into surrounding waters, wherein biodegradation is carried out by aqueous phase microbes. Under these conditions, oil concentration are effectively reduced below toxicity threshold limits, and biodegradation becomes the most important process in reducing the total mass of petroleum hydrocarbons in the environment. By enabling rapid dispersion and biodegradation of surface oil slicks at sea, the use of chemical oil dispersants can be effective in preventing heavy oiling of sensitive coastal environments such as beaches and wetlands, and consequently mitigates risk associated with marine and terrestrial wildlife coming into direct contact with a slick.
Clinical performance of a new silver dressing, Contreet Foam, for chronic exuding venous leg ulcers.

OBJECTIVE This study aimed to evaluate the safety and performance of a new sustained silver-releasing dressing, Contreet Foam (Coloplast A/S), in the treatment of moderately to highly exuding chronic venous leg ulcers in which healing is delayed due to the presence of bacteria. METHOD The clinical performance of Contreet Foam was studied for four weeks in 25 patients with moderately to highly exuding delayed-healing venous leg ulcers. Healing was assessed on a weekly basis with reference to the wound-bed tissue composition, degree of odour and pain, dressing performance and the dressing's effect on the peri-ulcer area. Blood samples were analysed for silver content. RESULTS Twenty-three out of 25 patients completed the study. One ulcer healed and no wound infections occurred during the study period. A mean 56% reduction in ulcer area (from 15.6 to 6.9 cm2) was recorded during the four weeks, and there was a mean 25% reduction in granulation tissue from dull to healthy after one week. Wound odour reduced significantly after one week. Mean dressing wear time was 3.1 days, and there were only minimal incidences of leakage. Serum silver levels did not exceed reference values. CONCLUSION Contreet Foam was found to be safe and performed well when used in the treatment of delayed-healing chronic venous leg ulcers, combining effective antibacterial properties with excellent exudate management. DECLARATION OF INTEREST This study was supported by Coloplast A/S, Humlebaek, Denmark.
Unemployment Insurance and the Rate of Re-employment of Displaced Workers

The rate of transition from unemployment to re-employment for a sample of displaced workers is estimated using a semiparametric specification which allows the effects of unemployment insurance benefits to vary over time. Three results which would be missed by more restrictive specifications demonstrate the value of this approach: (1) The effects of UI benefits decline and eventually disappear as the date of expiration approaches, (2) Expiration of UI benefits are an inadequate explanation of the spikes commonly observed in nonparametric sample hazard rates for re-employment, (3) UI benefits do not significantly affect the rate at which a displaced worker becomes re-employed in his or her previous industry, but reduce the rate for transitions to other industries. Copyright 1991 by MIT Press.
Do clusters capabilities matter? An empirical application of the resource-based view in clusters

The resource-based view (RBV) of the firm has been applied to territories, although academia has not frequently undertaken exploration of RBV applied to clusters in an empirical base. The goal of this paper aims at empirically translating RBV to the territory with a double objective. First, the work seeks to understand which are the cluster's resources and capabilities. Second, the paper evaluates whether a cluster's unique set of resources and capabilities could influence a cluster's performance. Research is applied to leading European ceramic tile clusters located in Spain (Castellon) and Italy (Emilia-Romagna). Comparing clusters in the same industry allows benchmarking and the metrics make more sense. Secondary data and face-to-face semi-structured interviews with managers from the R&D Institutes, institutional agents and Castellon (59) and Emilian (19) firms assess a cluster's resources and capabilities. The employed variables address skilled labour availability, social capital, linkages, business sophistication and network effects. In addition, and through the utilization of financial and productivity data the work analyses whether there are performance differences. Results indicate that clusters have a unique set of resources and capabilities and a certain performance level. On the whole, a cluster's unique set of resources and capabilities matter. The paper offers a methodological approach to tackle empirically the RBV application to clusters.
MEDICAL director.

which will be glad to provlde the latest information on any changes made to the text, plans for new edltlons, and reprints and translations already available. Publications of the World Health Organization enjoy copyright protection in accordance with the provisions of Protocol 2 of the Universal Copyr~ght Convention. All rlghts reserved. The designations employed and the presentation of the material ~n this publication do not imply the expression of any oplnlon whatsoever on the part of the Secretariat of the World Health Organ~zatlon concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. The mentlon of specific companies or of certain manufacturers' products does not Imply that they are endorsed or recommended by the World Health Organization In preference to others of a similar nature that are not mentioned. Errors and omissions excepted, the names of proprietary products are distlngulshed by initial capital letters.
Price-Cost Margins and Structural Change: Sub-Contracting within the Salmon Marketing Chain

Some recent studies have benefited from advances in time series econometrics in order to evaluate price transmission mechanisms along the marketing chain. Due to the length of time series, structural changes may affect the evaluation of price-cost margins. In the case of the fresh salmon trade between Norway and France, the gross margin between producers and retailers has changed in level between January 1988 and December 1999. This article accurately identifies the date of a structural change using a range of recent ADF testing procedures (Gregory-Hansen tests, forward and backward recursive tests), before looking for the causes of the change through a survey. Two major factors can be identified: the product form and the marketing channel. Interestingly, both the increasing level of processing and the development of supermarket chains have resulted in a new role for the intermediaries, shifting from mere commercial intermediation to sub-contracting for the big retailers. Copyright Blackwell Publishing Ltd 2005.
EVALUATING THE PERFORMANCE OF LOCAL GOVERNMENT

Compared with most other industrialised nations, the UK government places greatest weight on performance assessments of local authorities as a tool to ensure high levels of public service standards and efficiency of public spending in areas such as education, social services, housing, culture, and benefits administration. Annual comprehensive performance assessments (CPA), published by the Audit Commission for England, are now an integral part of the central–local government nexus. By contrast, Wales and Scotland have embarked on different routes in the post-devolution era and have developed assessment frameworks that are much less prescriptive, less intrusive, and more reliant on self-assessment. Drawing on 20 semi-structured elite interviews with auditors, auditees, and other stakeholders in the three nations, this article evaluates the lessons learned from the respective assessment regimes. It also assesses critically the plans to replace the English CPA system from 2008 onwards with a regime that emulates Wales and Scotland-style self-assessments carried out by auditees themselves.
Acute Middle East Respiratory Syndrome Coronavirus: Temporal Lung Changes Observed on the Chest Radiographs of 55 Patients.

OBJECTIVE The objective of our study was to describe lung changes on serial chest radiographs from patients infected with the acute Middle East respiratory syndrome corona-virus (MERS-CoV) and to compare the chest radiographic findings and final outcomes with those of health care workers (HCWs) infected with the same virus. Chest radiographic scores and comorbidities were also examined as indicators of a fatal outcome to determine their potential prognostic value. MATERIALS AND METHODS Chest radiographs of 33 patients and 22 HCWs infected with MERS-CoV were examined for radiologic features indicative of disease and for evidence of radiographic deterioration and progression. Chest radiographic scores were estimated after dividing each lung into three zones. The scores (1 [mild] to 4 [severe]) for all six zones per chest radiographic examination were summed to provide a cumulative chest radiographic score (range, 0-24). Serial radiographs were also examined to assess for radiographic deterioration and progression from type 1 (mild) to type 4 (severe) disease. Multivariate logistic regression analysis, Kaplan-Meier survival curve analysis, and the Mann-Whitney U test were used to compare data of deceased patients with those of individuals who recovered to identify prognostic radiographic features. RESULTS Ground-glass opacity was the most common abnormality (66%) followed by consolidation (18%). Overall mortality was 35% (19/55). Mortality was higher in the patient group (55%, 18/33) than in the HCW group (5%, 1/22). The mean chest radiographic score for deceased patients was significantly higher than that for those who recovered (13 ± 2.6 [SD] vs 5.8 ± 5.6, respectively; p = 0.001); in addition, higher rates of pneumothorax (deceased patients vs patients who recovered, 47% vs 0%; p = 0.001), pleural effusion (63% vs 14%; p = 0.001), and type 4 radiographic progression (63% vs 6%; p = 0.001) were seen in the deceased patients compared with those who recovered. Univariate and logistic regression analyses identified the chest radiographic score as an independent predictor of mortality (odds ratio [OR], 1.38; 95% CI, 1.07-1.77; p = 0.01). The number of comorbidities in the patient group (n = 33) was significantly higher than that in the HCW group (n = 22) (mean number of comorbidities, 1.90 ± 1.27 vs 0.17 ± 0.65, respectively; p = 0.001). The Kaplan-Meier analysis revealed a median survival time of 15 days (95% CI, 4-26 days). CONCLUSION Ground-glass opacity in a peripheral location was the most common abnormality noted on chest radiographs. A higher chest radiographic score coupled with a high number of medical comorbidities was associated with a poor prognosis and higher mortality in those infected with MERS-CoV. Younger HCWs with few or no comorbidities had a higher survival rate.
Assessing Measurement Invariance of Export Market Orientation: A Study of Chinese and Non-Chinese Firms in China

In response to numerous calls for the cross-cultural validation of measures used in international research, the authors assess measurement invariance of the export market orientation (EMO) and export performance (EP) constructs using 491 Chinese and non-Chinese export ventures in China. The results show that both the EMO and the EP scales are invariant between Chinese and non-Chinese export ventures. In addition, different EMO components have differential effects on EP for Chinese versus non-Chinese firms. To achieve higher EP, Chinese firms should focus on export intelligence responsiveness, and non-Chinese firms should concentrate their efforts on export intelligence generation. The authors discuss implications and suggest directions for further research.
Premorbid functioning in a national population of male twins discordant for psychoses.

OBJECTIVE The goal of the current study was to compare premorbid behavioral and cognitive functioning between co-twins discordant for psychotic disorder and between these pairs of twins and pairs of twins with no psychotic disorders. METHOD The authors linked data from the Israeli Draft Board Registry, which contains cognitive and behavioral assessments of all 16-17-year-old male Israeli twins, with data from the National Psychiatric Hospitalization Case Registry. Pairs of male twins who were healthy at the time of testing but discordant for psychoses later on were compared with one another and with pairs of healthy male twins. RESULTS The affected twins performed significantly worse than healthy twins on measures of individual autonomy, social functioning, and physical activity and nonsignificantly worse on measures of abstract reasoning. There were no significant differences in cognitive or behavioral scores between the co-twins who did or did not develop psychotic disorders. CONCLUSIONS The authors conclude that these findings underscore the familial nature of behavioral and cognitive deficits antecedent to psychoses.
Pricing, Distribution and Adoption of Genetically Modified Seeds Under Alternative Information Regimes

This paper considers genetically modified (GM) seed adoption decisions by farmers in a developing country under two alternative information regimes (with and without perfect information regarding production conditions) that allows the monopolist producer of GM seeds to either practice perfect discrimination or uniform pricing. Under each regime we analyze two scenarios: when the government can and cannot credibly commit to the announced form of welfare enhancing intervention in the domestic seed market. We show that the optimal policy under either information regime is to subsidize the price of conventional seeds. The optimal size of the conventional seed subsidy depends systematically, in turn, on the (i) marginal cost of GM and conventional seeds, (ii) price of chemical pesticides, (iii) degree to which GM seeds increase productivity, (iv) range of pest pressure among farmers, and (v) intensity of seed usage (GM and conventional). Nonetheless, our findings pinpoint time-inconsistency of government policies as a possible reason for sub-optimal coverage of GM seeds in developing countries.