Miracle-dz/UniFAR-FTUs huggingface dataset:
Prospective survey of tick paralysis in dogs.

OBJECTIVE To obtain information on tick paralysis in dogs, including the nature of disease, host signalment, tick-host relationship, treatment, disease progression and recovery, and preventive measures. DESIGN A prospective survey of 577 dogs affected by tick paralysis was conducted during 1998. Forty-two veterinary clinics along the eastern coast of Australia were instructed to complete survey forms for the first 15 dogs that presented with tick paralysis during September to November. RESULTS Five percent of dogs died from tick paralysis. Younger dogs were more likely to survive. Long coat length was associated with a greater tick burden but not greater tick size, whereas coat thickness had no bearing on either. Dogs with mild disease recovered more quickly from tick paralysis. Respiratory and gait scores reflected disease severity and were good prognostic indicators. The size of the tick did not reflect the severity of the clinical condition it induced in the host. No method of tick removal or in situ treatment improved recovery time or reduced mortality. However, the time spent in hospital was significantly less for dogs from which the live tick was manually removed. Inspiratory stridor, evident in some dogs with tick paralysis, was not related to tick attachment on the neck. The use of acepromazine maleate or dexamethasone did not reduce recovery time or mortality. Increasing the dose of tick antitoxin serum (TAS) above 0.1 mL/kg had no effect on mortality or recovery time. Dogs with severe disease that received an additional dose of TAS were significantly less likely to survive. Subcutaneous use of TAS at the site of tick attachment was of no benefit in reducing mortality or time to initial clinical improvement. A registered preventative product had not been used on the majority of dogs. Clipping the coat to search for ticks did not reduce mortality. CONCLUSIONS Therapy needs to address cardiopulmonary dysfunction that may be due directly to the effect of tick toxin and not just respiratory compromise caused by progressive respiratory muscle failure.
Breakdown of Ar + SF6 under ac electric fields

In this study, alternating voltages with different values were employed to study the behavior of Ar mixed with SF6. The percentage of SF6 in Ar was varied from 5% to 90% at a total gas pressure of 50 kPa, 100 kPa, 150 kPa and 200 kPa, and the breakdown voltages of each gas mixture were recorded. Similar to earlier studies under static electric fields and impulse fields, it is observed that the breakdown strength of Ar has increased dramatically when mixed with a small percentage of SF6 under alternating voltages. However, the breakdown voltages did increase monotonically, but not dramatically for higher SF6 concentrations in Ar.
Projected changes in regional climate extremes arising from Arctic sea ice loss

The decline in Arctic sea ice cover has beenwidely documented and it is clear that this change is having profound impacts locally. An emerging and highly uncertain area of scientific research, however, is whether such Arctic change has a tangible effect onweather and climate at lower latitudes. Of particular societal relevance is the open question: will continued Arctic sea ice loss makemid-latitude weathermore extreme? Here we analyse idealized atmospheric general circulationmodel simulations, using two independentmodels, both forced by projected Arctic sea ice loss in the late twenty-first century.We identify robust projected changes in regional temperature and precipitation extremes arising solely due to Arctic sea ice loss. The likelihood and duration of cold extremes are projected to decrease over high latitudes and over central and eastern North America, but to increase over central Asia. Hot extremes are projected to increase in frequency and duration over high latitudes. The likelihood and severity of wet extremes are projected to increase over high latitudes, theMediterranean and central Asia; and their intensity is projected to increase over high latitudes and central and eastern Asia. The number of dry days over mid-latitude Eurasia and dry spell duration over high latitudes are both projected to decrease. There is closermodel agreement for projected changes in temperature extremes than for precipitation extremes. Overall, we find that extremeweather over central and easternNorth America ismore sensitive to Arctic sea ice loss than over othermid-latitude regions. Our results are useful for constraining the role of Arctic sea ice loss in shifting the odds of extremeweather, but must not be viewed as deterministic projections, as they do not account for drivers other than Arctic sea ice loss.
Assessment of modafinil on attentional processes in a five-choice serial reaction time test in the rat

It is well known that modafinil is an effective wake-promoting agent, but there is growing evidence to suggest that modafinil may also enhance some aspects of cognition. In man, modafinil has been shown to enhance vigilance in sleep-deprived and/or narcoleptic subjects and also to improve executive-type functioning (predominantly inhibitory response control processes) across a variety of human patient population groups. Preclinically, a delay-dependent improvement has been reported with modafinil in a mouse T-maze test of working memory. To investigate further the role of modafinil as a potential cognition enhancer, the effects of modafinil on attentional processes were assessed in the rat. The aim of the present study was to evaluate the potential of modafinil to enhance five-choice serial reaction time test (5-CSRT) performance. Lister Hooded rats received 32-128 mg/kg modafinil and 5-CSRT performance was assessed under standard and test parametric conditions in which the attentional load was increased, and also under conditions of scopolamine pre-treatment. Modafinil failed to significantly enhance 5-CSRT performance under standard conditions. Similarly, modafinil was unable to reverse the deficits in accuracy and/or increased omission errors induced by either parametric or pharmacological manipulations. Indeed, at higher doses, modafinil caused an increase in premature responding under certain test conditions, suggestive of increased impulsivity. The present findings suggest that, although modafinil may enhance vigilance in sleep-deprived human subjects, attentional processes in normal awake rats remain unaffected. No evidence was found to support a modafinil-induced improvement in response control; rather, under conditions of increased attentional load, modafinil appeared to facilitate impulsive responding. Finally, the failure of modafinil to improve a scopolamine-induced performance deficit suggests that modafinil does not act on the cholinergic system directly.
Development of a disease‐specific questionnaire to measure health‐related quality of life in liver transplant recipients

Currently, no disease‐targeted instrument is available for measuring health‐related quality of life (HRQOL) in liver transplant recipients. We developed and tested a post–liver transplant quality of life (pLTQ) instrument. Item selection for the pLTQ instrument was based on responses from liver transplant recipients, 12 liver experts, and a literature search. Impact scores were generated, and a factor analysis was conducted to organize the items into domains. Questions were constructed for each item, and redundant questions were removed. The pLTQ instrument was initially administered to 196 liver transplant patients and then was again administered to 77 patients 6 to 9 months later with a generic HRQOL survey [Medical Outcomes Study Short Form 36 (SF‐36)]. Analysis of variance was used to compare the scores of patients at different times since transplantation and with various indications for transplantation. After redundancies were eliminated, the pLTQ instrument included 32 items in 8 domains: Emotional Function, Worry, Medications, Physical Function, Healthcare, Graft Rejection Concern, Financial, and Pain. We found stable pLTQ instrument and SF‐36 instrument scores over time. Data 6 to 9 months after the initial assessment indicated stable quality of life outcomes. The pLTQ instrument is applicable to a variety of liver transplant recipients. The questionnaire was tested with a cross‐sectional and longitudinal approach. Liver Transpl 17:567‐579, 2011. © 2011 AASLD.
The control and importance of hyaluronan synthase expression in palatogenesis

Development of the lip and palate involves a complex series of events that requires the close co-ordination of cell migration, growth, differentiation, and apoptosis. Palatal shelf elevation is considered to be driven by regional accumulation and hydration of glycosoaminoglycans, principally hyaluronan (HA), which provides an intrinsic shelf force, directed by components of the extracellular matrix (ECM). During embryogenesis, the extracellular and pericellular matrix surrounding migrating and proliferating cells is rich in HA. This would suggest that HA may be important in both shelf growth and fusion. TGFβ3 plays an important role in palatogenesis and the corresponding homozygous null (TGFβ3−/−) mouse, exhibits a defect in the fusion of the palatal shelves resulting in clefting of the secondary palate. TGFβ3 is expressed at the future medial edge epithelium (MEE) and at the actual edge epithelium during E14.5, suggesting a role for TGFβ3 in fusion. This is substantiated by experiments showing that addition of exogenous TGFβ3 can “rescue” the cleft palate phenotype in the null mouse. In addition, TGFβ1 and TGFβ2 can rescue the null mouse palate (in vitro) to near normal fusion. In vivo a TGFβ1 knock-in mouse, where the coding region of the TGFβ3 gene was replaced with the full-length TGFβ1 cDNA, displayed complete fusion at the mid portion of the secondary palate, whereas the anterior and posterior regions failed to fuse appropriately. We present experimental data indicating that the three HA synthase (Has) enzymes are differentially expressed during palatogenesis. Using immunohistochemistry (IHC) and embryo sections from the TGFβ3 null mouse at days E13.5 and E14.5, it was established that there was a decrease in expression of Has2 in the mesenchyme and an increase in expression of Has3 in comparison to the wild-type mouse. In vitro data indicate that HA synthesis is affected by addition of exogenous TGFβ3. Preliminary data suggests that this increase in HA synthesis, in response to TGFβ3, is under the control of the PI3kinase/Akt pathway.
Diverse responses of phenology to global changes in a grassland ecosystem

Shifting plant phenology (i.e., timing of flowering and other developmental events) in recent decades establishes that species and ecosystems are already responding to global environmental change. Earlier flowering and an extended period of active plant growth across much of the northern hemisphere have been interpreted as responses to warming. However, several kinds of environmental change have the potential to influence the phenology of flowering and primary production. Here, we report shifts in phenology of flowering and canopy greenness (Normalized Difference Vegetation Index) in response to four experimentally simulated global changes: warming, elevated CO2, nitrogen (N) deposition, and increased precipitation. Consistent with previous observations, warming accelerated both flowering and greening of the canopy, but phenological responses to the other global change treatments were diverse. Elevated CO2 and N addition delayed flowering in grasses, but slightly accelerated flowering in forbs. The opposing responses of these two important functional groups decreased their phenological complementarity and potentially increased competition for limiting soil resources. At the ecosystem level, timing of canopy greenness mirrored the flowering phenology of the grasses, which dominate primary production in this system. Elevated CO2 delayed greening, whereas N addition dampened the acceleration of greening caused by warming. Increased precipitation had no consistent impacts on phenology. This diversity of phenological changes, between plant functional groups and in response to multiple environmental changes, helps explain the diversity in large-scale observations and indicates that changing temperature is only one of several factors reshaping the seasonality of ecosystem processes.
Frontiers in Synaptic Neuroscience Synaptic Neuroscience

lead to a strengthening of the synapse between the two cells. This hypothesis for associative synaptic plasticity was later extended by Stent (1973), who suggested the converse idea for bidirectional synaptic modification – that persistent failure of a presynaptic input to activate the postsynaptic neuron should lead to weakening of that synapse. In the years that followed, Hebb's postulate exerted a profound influence on theoretical and experimental neurophysiology. Spurred by the discovery of hippocampal long-term potentiation (LTP) by Bliss and Lømo (1973), along with other experimental reports of changes in cortical activity (Bindman et al., 1962), many different theoretical frameworks for long-term synaptic modification were proposed, such as the covariance model One of the most successful paradigms for the study of long-term synaptic plasticity is the Bienenstock–Cooper–Munro (BCM) sliding threshold model (Bienenstock et al., 1982). In this scheme, the sign and degree of synaptic modification is a nonlinear function of postsynaptic spike rate. When the postsynaptic spike frequency is above a certain threshold (θ m) LTP is induced, while long-term depression (LTD) is induced when the firing rate is below θ m but greater than zero. The value of θ m is not fixed, but varies so as to prevent runaway potentiation or depression to saturation. The BCM model was originally proposed as a method by which syn-aptic modifications could result in the development and plasticity
A truthful mechanism for fair load balancing in distributed systems

In this paper we consider the problem of designing load balancing protocols in distributed systems where the participants (e.g. computers, users) are capable of manipulating the load allocation algorithm in their own interest. Using techniques from mechanism design theory we design a mechanism for fair load balancing in heterogeneous distributed systems. We prove that our mechanism is truthful and satisfies the voluntary participation condition. Based on the proposed mechanism we derive a fair load balancing protocol called FAIR-LBM. Finally, we study the effectiveness of our protocol by simulations.
Negative-pressure ventilation: better oxygenation and less lung injury.

RATIONALE Conventional positive-pressure ventilation delivers pressure to the airways; in contrast, negative pressure is delivered globally to the chest and abdomen. OBJECTIVES To test the hypothesis that ventilation with negative pressure results in better oxygenation and less injury than with positive pressure. METHODS Anesthetized, surfactant-depleted rabbits were ventilated for 2.5 hours in pairs (positive or negative). Tidal volume was 12 ml . kg(-1), normocapnia was maintained by adjusting respiratory rate, and Fi(O(2)) was 1.0. MEASUREMENTS AND MAIN RESULTS Lung injury was assessed with histologic scoring, perfusion using thermodilution (global perfusion), and injected intravascular microspheres (regional perfusion); and dynamic computed tomography was used to determine inflation patterns. Negative pressure was associated with a higher Pa(O(2)), a lower Pa-Pet(CO(2)) gradient (despite identical minute ventilation), and less lung injury. Lung perfusion (global and regional) was similar with positive and negative pressure. Positive end-expiratory pressure applied to the airway was more efficiently transmitted to the pleural space than comparable levels of negative end-expiratory pressure applied to the chest wall; however, the oxygenation associated with any level of end-expiratory lung volume was greater when achieved by negative versus positive pressure. Dynamic computed tomography suggested that lung distension achieved with negative pressure is characterized by greater proportions of normally aerated lung (with less atelectasis) during inspiration and at end-expiration. CONCLUSIONS Negative-pressure ventilation results in superior oxygenation that is unrelated to lung perfusion and may be explained by more effective inflation of lung volume during both inspiration and expiration.
Asymmetry of the Indian Ocean Dipole. Part I: Observational Analysis*

Abstract The physical mechanism for the amplitude asymmetry of SST anomalies (SSTA) between the positive and negative phases of the Indian Ocean dipole (IOD) is investigated, using Simple Ocean Data Assimilation (SODA) and NCAR–NCEP data. It is found that a strong negative skewness appears in the IOD east pole (IODE) in the mature phase [September–November (SON)], while the skewness in the IOD west pole is insignificant. Thus, the IOD asymmetry is primarily caused by the negative skewness in IODE. A mixed-layer heat budget analysis indicates that the following two air–sea feedback processes are responsible for the negative skewness. The first is attributed to the asymmetry of the wind stress–ocean advection–SST feedback. During the IOD developing stage [June–September (JJAS)], the ocean linear advection tends to enhance the mixed-layer temperature tendency, while nonlinear advection tends to cool the ocean in both the positive and negative events, thus contributing to the negative skewness in IODE. The se.
Oxygen-Independent Stabilization of Hypoxia Inducible Factor (HIF)-1 during RSV Infection

Background Hypoxia-inducible factor 1 (HIF)-1α is a transcription factor that functions as master regulator of mammalian oxygen homeostasis. In addition, recent studies identified a role for HIF-1α as transcriptional regulator during inflammation or infection. Based on studies showing that respiratory syncytial virus (RSV) is among the most potent biological stimuli to induce an inflammatory milieu, we hypothesized a role of HIF-1α as transcriptional regulator during infections with RSV. Methodology, Principal Findings We gained first insight from immunohistocemical studies of RSV-infected human pulmonary epithelia that were stained for HIF-1α. These studies revealed that RSV-positive cells also stained for HIF-1α, suggesting concomitant HIF-activation during RSV infection. Similarly, Western blot analysis confirmed an approximately 8-fold increase in HIF-1α protein 24 h after RSV infection. In contrast, HIF-1α activation was abolished utilizing UV-treated RSV. Moreover, HIF-α-regulated genes (VEGF, CD73, FN-1, COX-2) were induced with RSV infection of wild-type cells. In contrast, HIF-1α dependent gene induction was abolished in pulmonary epithelia following siRNA mediated repression of HIF-1α. Measurements of the partial pressure of oxygen in the supernatants of RSV infected epithelia or controls revealed no differences in oxygen content, suggesting that HIF-1α activation is not caused by RSV associated hypoxia. Finally, studies of RSV pneumonitis in mice confirmed HIF-α-activation in a murine in vivo model. Conclusions/Significance Taking together, these studies suggest hypoxia-independent activation of HIF-1α during infection with RSV in vitro and in vivo.
KissKissBan: a competitive human computation game for image annotation

In this paper, we propose a competitive human computation game, KissKissBan (KKB), for image annotation. KKB is different from other human computation games since it integrates both collaborative and competitive elements in the game design. In a KKB game, one player, the blocker, competes with the other two collaborative players, the couples; while the couples try to find consensual descriptions about an image, the blocker's mission is to prevent the couples from reaching consensus. Because of its design, KKB possesses two nice properties over the traditional human computation game. First, since the blocker is encouraged to stop the couples from reaching consensual descriptions, he will try to detect and prevent coalition between the couples; therefore, these efforts naturally form a player-level cheating-proof mechanism. Second, to evade the restrictions set by the blocker, the couples would endeavor to bring up a more diverse set of image annotations. Experiments hosted on Amazon Mechanical Turk and a gameplay survey involving 17 participants have shown that KKB is a fun and efficient game for collecting diverse image annotations.
Single T Cell Receptor-Mediated Recognition of an Identical HIV-Derived Peptide Presented by Multiple HLA Class I Molecules1

A dual specific human CTL clone harboring one β and two inframe α transcripts of TCR was previously reported to recognize an HIV Pol-derived nonapeptide (IPLTEEAEL) endogenously presented by both syngeneic HLA-B*3501 and HLA-B*5101. In the current study, a retrovirus-mediated TCR transfer of individual α- and β-chains to TCR-negative hybridoma showed that Vα12. 1 TCR in complex with Vβ5. 6 were responsible for the peptide-specific response in the context of both HLA-B*3501 and HLA-B*5101, confirming single TCR-mediated dual specificity. The second TCR-α chain was not somehow expressed on the cell surface. Remarkably, the Vα12. 1/Vβ5. 6 TCR also recognized the same peptide presented by allogeneic HLA class I molecules that share the similar peptide-binding motifs, such as HLA-B*5301 and HLA-B*0702. The sensitivity of peptide recognition by the Vα12/Vβ5. 6 TCR appeared to be comparable when the peptide was presented by syngeneic and allogeneic HLA class I molecules, with changes in T cell responsiveness caused largely by peptide-binding capacity. Moreover, the CTL clone bearing Vα12. 1/Vβ5. 6 TCR showed substantial cytolytic activity against the peptide-loaded cells expressing HLA-B*3501, HLA-B*5101, HLA-B*5301, or HLA-B*0702, providing further evidence that a single TCR complex can recognize the same peptide presented by a broad range of HLA class I molecules. A TCR with fine specificity for an HIV Ag but broad specificity to multiple HLA molecules may provide an advantage to the generation of allorestricted, peptide-specific T cells, and thus could be a potent candidate for immunotherapy against HIV infection.
Progression of nuclear sclerosis based on changes in refractive values after lens-sparing vitrectomy in proliferative diabetic retinopathy

Background Nuclear sclerosis (NS) based on the Emery–Little classification and refractive values after lens-sparing vitrectomy was compared between proliferative diabetic retinopathy (DR) patients and nondiabetic patients. Methods Progression of NS based on the Emery–Little classification and changes in refractive values were compared between 13 proliferative DR patients (14 eyes, DR group) and 14 nondiabetic patients (14 eyes, non-DR group) who underwent lens-sparing vitrectomy. All patients revealed grade I NS based on the Emery–Little classification. Mean patient age and refractive value just after surgery were 56.07 years and −0.33 diopters (D) in the DR group, and 57.06 years and −0.96 D in the non-DR group. Results The Emery–Little classification in the DR group at 6 and 24 months postoperative were grade I (13 eyes)/grade II (one eye) and grade I (eleven eyes)/grade II (three eyes), respectively. Mean refractive values in the DR group at 6, 12, and 24 months postoperative were +0.28 D, +0.27 D, and +0.37 D, respectively. The Emery–Little classification in the non-DR group at 6 and 24 months (or preoperative for patients undergoing cataract surgery) were grade I (five eyes)/grade II (eight eyes) and grade I (zero eyes)/grade II (eight eyes)/grade III (five eyes), respectively. The mean refractive value in the non-DR group at 6 months postoperative was −3.20 D. All eyes exhibited myopic changes and progression of NS. Conclusion The findings of this study show that the progression of NS postvitrectomy is mild, even for DR patients 50 years of age or older, thus suggesting the need to reconsider the indications for simultaneous cataract surgery with vitrectomy.