Miracle-dz/UniFAR-FTUs huggingface dataset:
Epithelial dynamics of pancreatic branching morphogenesis

The mammalian pancreas is a highly branched gland, essential for both digestion and glucose homeostasis. Pancreatic branching, however, is poorly understood, both at the ultrastructural and cellular levels. In this article, we characterize the morphogenesis of pancreatic branches, from gross anatomy to the dynamics of their epithelial organization. We identify trends in pancreatic branch morphology and introduce a novel mechanism for branch formation, which involves transient epithelial stratification and partial loss of cell polarity, changes in cell shape and cell rearrangements, de novo tubulogenesis and epithelial tubule remodeling. In contrast to the classical epithelial budding and tube extension observed in other organs, a pancreatic branch takes shape as a multi-lumen tubular plexus coordinately extends and remodels into a ramifying, single-lumen ductal system. Moreover, our studies identify a role for EphB signaling in epithelial remodeling during pancreatic branching. Overall, these results illustrate distinct, step-wise cellular mechanisms by which pancreatic epithelium shapes itself to create a functional branching organ.
EFFECT OF COMPOST AND NUMBER OF CUTTINGS ON PRODUCTIVITY OF CORIANDRUM SATIVUM L. UNDER SINAI CONDITIONS

wo field experiments were carried out at El-Maghara Research Station (Middle Sinai) of the Desert Research Center (DRC), during 2014/2015 and 2015/2016 seasons, to study the effect of two doses of organic compost; 10 and 20 m 3 /feddan and three cuttings frequencies (without cutting, one cutting at 45 days after sowing and two successive cutting at 45 and 60 days after sowing) on the growth and essential oil content of Coriandrum sativum L. plant grown in sandy soil. The obtained results revealed that, the best growth parameters (plant height, number of branches, weight of 1000 seeds (g),weight of seeds per plant (g), yield of seeds (kg/feddan), oil percentage, oil yield (L/feddan), total nitrogen and carbohydrate percentages and essential oil composition were obtained by using a combination of 20 m 3 /feddan compost and one cutting, after 45 days after sowing, except for plant height that showed the beast results associated with “without cutting” treatment.
CZ: multiple inheritance without diamonds

Multiple inheritance has long been plagued with the "diamond" inheritance problem, spurring a variety of solutions, such as virtual inheritance, mixins and traits. We offer a different solution: a language that supports multiple inheritance but forbids diamond inheritance. We maintain expressiveness through a "requires" construct (inspired by Scala) that provides subtyping without inheritance diamonds. Our novel no-diamond restriction offers the benefit of allowing multiple inheritance to co-exist neatly with fields, without resorting to tactics such as virtual inheritance. We believe our solution is more expressive than previous attempts to solve the diamond inheritance problem.
A Multigrid Method Enhanced by Krylov Subspace Iteration for Discrete Helmholtz Equations

Standard multigrid algorithms have proven ineffective for the solution of discretizations of Helmholtz equations. In this work we modify the standard algorithm by adding GMRES iterations at coarse levels and as an outer iteration. We demonstrate the algorithm's effectiveness through theoretical analysis of a model problem and experimental results. In particular, we show that the combined use of GMRES as a smoother and outer iteration produces an algorithm whose performance depends relatively mildly on wave number and is robust for normalized wave numbers as large as 200. For fixed wave numbers, it displays grid-independent convergence rates and has costs proportional to the number of unknowns.
Smallcheck and lazy smallcheck: automatic exhaustive testing for small values

This paper describes two Haskell libraries for property-based testing. Following the lead of QuickCheck, these testing libraries SmallCheck and Lazy SmallCheck also use type-based generators to obtain test-sets of finite values for which properties are checked, and report any counter-examples found. But instead of using a sample of randomly generated values they test properties for all values up to some limiting depth, progressively increasing this limit. The paper explains the design and implementation of both libraries and evaluates them in comparison with each other and with QuickCheck.
Negative Regulation of NK Cell Activities by Inhibitory Receptor CD94/NKG2A Leads to Altered NK Cell-Induced Modulation of Dendritic Cell Functions in Chronic Hepatitis C Virus Infection1

NK cells are potent activators of dendritic cells (DCs), but it remains obscure how third-party cells affect the ability of NK cells to modulate DC functions. We show here that NK cells derived from healthy donors (N-NK), when cocultured with human liver epithelial cells, induced maturation as well as activation of DCs, such as increased migratory capacity as well as T cell stimulatory activity. In contrast, NK cells from chronic hepatitis C virus-infected donors (HCV-NK) were not capable of activating DCs under the same conditions. In comparison to N-NK, HCV-NK showed higher expression of CD94/NKG2A and produced IL-10 and TGFβ when cultured with hepatic cells, most of which express HLA-E, a ligand for CD94/NKG2A. Blockade of NKG2A restored the ability of HCV-NK to activate DCs, which appeared to result from the reduced NK cell production of IL-10 and TGFβ. The blockade also endowed HCV-NK with an ability to drive DCs to generate Th1-polarized CD4+ T cells. These findings show that NK cell modulation of DCs is regulated by third-party cells through NK receptor and its ligand interaction. Aberrant expression of NK receptors may have an impact on the magnitude and direction of DC activation of T cells under pathological conditions, such as chronic viral infection.
Polymorphism of the promoter region of C-509T of transforming growth factor-beta1 gene and ulcerative colitis.

BACKGROUND Transforming growth factor-beta is a regulatory protein that plays a key role in inflammatory, fibrotic, and immunological events in the intestinal mucosa. Recently, attention has been focused on the role of transforming growth factor-beta in the etiopathogenesis of inflammatory bowel disease. Enhanced expression of transforming growth factor-beta mRNA in the lamina propria and a disordered expression pattern of transforming growth factor-beta1 receptors I and II in epithelial cells have been documented in the colonic mucosa of patients with ulcerative colitis and Crohn's disease. Based on these associations, we report in this study, the restriction fragment length polymorphism-polymerase chain reaction and allele frequencies of the transforming growth factor-beta gene polymorphisms in a population of Iranian patients with ulcerative colitis and healthy controls. We analyzed whether these two polymorphisms are related with the disease characteristics. METHODS One hundred fifty-seven (75 males and 82 females) unrelated patients with ulcerative colitis attending the Departments of Gastroenterology, Nemazi and Faghihi Hospitals, affiliated to Shiraz University of Medical Sciences, Shiraz, Iran were enrolled into this study. Ninety-four age- and sex-matched healthy volunteers with no history of chronic bloody diarrhea and abdominal pain (41 males and 53 females) served as the control group. The change at position -509 (C/T) of the transforming growth factor-beta1 gene was studied using restriction fragment length polymorphism-polymerase chain reaction in this study. RESULTS The mean age of patients was 36.4 (range: 23 - 51) years. The genotype at position -509 (C/T) in 58 (37%) patients with ulcerative colitis, and 39 (41.5%) normal subjects, were homozygous as CC. In addition, 65 (41.5%) patients and 44 (47%) normal individuals were heterozygous as CT. Thirty-four (21.5%) of 157 patients, and 11 (11.5%) of 94 normal individuals, were homozygous as TT. There was no statistically significant difference between patients and normal female individuals in respect to genotype distribution and allele frequency at the said position (P = 0.138). CONCLUSION No association could be found between transforming growth factor-beta1 -509 (C/T) promoter gene polymorphism and patients with ulcerative colitis.
Male Circumcision in the General Population of Kisumu, Kenya: Beliefs about Protection, Risk Behaviors, HIV, and STIs

Using a population-based survey we examined the behaviors, beliefs, and HIV/HSV-2 serostatus of men and women in the traditionally non-circumcising community of Kisumu, Kenya prior to establishment of voluntary medical male circumcision services. A total of 749 men and 906 women participated. Circumcision status was not associated with HIV/HSV-2 infection nor increased high risk sexual behaviors. In males, preference for being or becoming circumcised was associated with inconsistent condom use and increased lifetime number of sexual partners. Preference for circumcision was increased with understanding that circumcised men are less likely to become infected with HIV.
Ventilation and the oculocardiac reflex

A randomised prospective study was carried out in children undergoing surgery for squint correction, to determine the value of controlled ventilation as a prophylaxis against the occurrence of the oculocardiac reflex. One hundred patients anaesthetised with nitrous oxideloxygen and halothane were randomly assigned to either ventilated or spontaneously breathing groups of 50 each. Half the patients in each group received glycopyrronium 7.5 μg/kg intravenously at the time of induction of anaesthesia. Heart rate, rhythm, blood pressure and end tidal CO2 concentration were monitored throughout. A positive oculocardiac reflex. defined as a fall in heart rate of 20% or more and/or the occurrence of dysrhythmias, was observed in 72% of spontaneously breathing patients and in 100% of ventilated patients not receiving prophylactic intravenous glycopyrronium. The incidence of a positive reflex in patients receiving glycopyrronium was 10% (4 and 16% respectively in spontaneously breathing and ventilated patients). It is concluded that controlled ventilation is of no value as a preventive measure against the occurrence of the oculocardiac reflex in patients undergoing squint surgery and that prophylaxis is safely achieved with the use of intravenous glycopyrronium.
The role of grounding in collaborative learning tasks

Collaborative learning tasks involve interaction between multiple participants, who thus need to maintain some degree of mutual understanding. The process by which this is accomplished is termed grounding . The way in which collaboration, grounding and learning take place is largely determined by the task, the situation and the tools available. This paper discusses relations between grounding, collaboration and learning, drawing on research from two main areas: the Language Sciences and Cultural-Historical Activity Theory ("CHAT"). We build a unifying perspective of mutual understanding mediated by material and semiotic tools that can be used for analysis as well as for design of collaborative learning tasks, especially those that are carried out via computermediated communication. We illustrate the perspective with reference to a particular computermediated collaborative learning situation in the domain of physics.
A Comparative Analysis of Clustering Algorithms

Clustering is a process of grouping a set of similar data objects within the same group based on similarity criteria (i.e. based on a set of attributes). There are many clustering algorithms. The objective of this paper is to perform a comparative analysis of four clustering algorithms namely Kmeans algorithm, Hierarchical algorithm, Expectation and maximization algorithm and Density based algorithm. These algorithms are compared in terms of efficiency and accuracy, using WEKA tool. The data for clustering is used in normalized and as well as unnormalized format. In terms of efficiency and accuracy K-means produces better results as compared to other algorithms.
Psychophysical Investigations into the Role of Low-Threshold C Fibres in Non-Painful Affective Processing and Pain Modulation

We recently showed that C low-threshold mechanoreceptors (CLTMRs) contribute to touch-evoked pain (allodynia) during experimental muscle pain. Conversely, in absence of ongoing pain, the activation of CLTMRs has been shown to correlate with a diffuse sensation of pleasant touch. In this study, we evaluated (1) the primary afferent fibre types contributing to positive (pleasant) and negative (unpleasant) affective touch and (2) the effects of tactile stimuli on tonic muscle pain by varying affective attributes and frequency parameters. Psychophysical observations were made in 10 healthy participants. Two types of test stimuli were applied: stroking stimulus using velvet or sandpaper at speeds of 0.1, 1.0 and 10.0 cm/s; focal vibrotactile stimulus at low (20 Hz) or high (200 Hz) frequency. These stimuli were applied in the normal condition (i.e. no experimental pain) and following the induction of muscle pain by infusing hypertonic saline (5%) into the tibialis anterior muscle. These observations were repeated following the conduction block of myelinated fibres by compression of sciatic nerve. In absence of muscle pain, all participants reliably linked velvet-stroking to pleasantness and sandpaper-stroking to unpleasantness (no pain). Likewise, low-frequency vibration was linked to pleasantness and high-frequency vibration to unpleasantness. During muscle pain, the application of previously pleasant stimuli resulted in overall pain relief, whereas the application of previously unpleasant stimuli resulted in overall pain intensification. These effects were significant, reproducible and persisted following the blockade of myelinated fibres. Taken together, these findings suggest the role of low-threshold C fibres in affective and pain processing. Furthermore, these observations suggest that temporal coding need not be limited to discriminative aspects of tactile processing, but may contribute to affective attributes, which in turn predispose individual responses towards excitatory or inhibitory modulation of pain.
Intravenous rt-PA for acute stroke: comparing its effectiveness in younger and older patients

Objective: To study the short and long term differences in outcome between patients ⩾80 years of age and those ⩽79 years of age who received intravenous recombinant tissue plasminogen activator (iv rt-PA) for acute stroke within the first 3 hours of symptom onset. Methods: We studied consecutive patients treated with iv rt-PA for acute stroke, with prospective follow up of up to 3 years. Outcome measures included National Institutes of Health Stroke Scale (NIHSS) score, Barthel Index (BI), modified Rankin score (MRS), and stroke mortality. Patients were split into two groups: younger (⩽79 years) and older (⩾80 years). Results: There were 65 patients in the younger cohort and 31 patients in the older. Older patients were more likely to present with more severe baseline stroke (p = 0.04; odds ratio (OR) 3.04; 95% confidence interval (CI) 1.03 to 8.98). Stroke mortality at 90 days was 10.8% in the younger and 32.3% in the older cohort (p = 0.01). At 90 days’ follow up, patients in the older cohort with more severe stroke (NIHSS score ⩾11) were nearly 10 times more likely to have poor outcome compared with their younger counterparts presenting with severe stroke (p = 0.001; OR = 10.36; 95% CI 2.16 to 49.20). Baseline stroke severity and age were the only independent and equal predictors for stroke outcome. No threshold was found for age or baseline stroke severity predicting outcome. Conclusion: Older patients presenting with more severe baseline stroke are much less likely to benefit from iv rt-PA as compared with their younger counterparts.
ON GROTHENDIECK'S CONJECTURE ABOUT PRINCIPAL HOMOGENEOUS SPACES FOR SOME CLASSICAL ALGEBRAIC GROUPS

In the present paper we investigate the question about the injectivity of the map F(R) ! F(K) induced by the canonical inclusion of a local regular ring of geometric type R to its field of fractions K for a homotopy invariant functor F with transfers satisfying some additional properties. As an application we get the original proof of Special Unitary Case of Grothendieck's conjecture about principal homogeneous spaces and some other interesting examples.
Human-inspired walking via unified PD and impedance control

This paper describes a torque control scheme unifying feedback PD control and feed-forward impedance control to realize human-inspired walking on a novel planar footed bipedal robot: AMBER2. It starts with high fidelity modeling of the robot including nonlinear dynamics, motor model, and impact dynamics. Human data is then used by an optimization algorithm to produce a human-like gait that can be implemented on the robot. To realize the bipedal walking, first a PD controller is utilized to track the optimized trajectory. Next, impedance control parameters are estimated from the experimental data. Finally, the unified PD, impedance torque control law is experimentally realized on the bipedal robot AMBER2. Through the evidence of sustainable and unsupported walking on AMBER2 showing high consistency with the simulated gait, the feasibility of AMBER2 walking scheme will be verified.
Osteopenia of prematurity.

INTRODUCITON . 169 CLINICAL CASES . 170 INCIDENCE . • . •. 173 PATHOPHYSIOLOGy 173 DIAGNOSIS . 176 TREATMENT/OUTCOME 180
Polymorphisms in CYP1B1, CYP3A5, GSTT1, and SULT1A1 Are Associated with Early Age Acute Leukemia

Based on observational studies, early age leukemia (EAL) was associated with maternal hormone exposure during pregnancy. We studied the association between genetic polymorphisms of estrogen metabolism and EAL. Using data from the Brazilian Collaborative Study Group of Infant Acute Leukemia (2000–2012), 350 cases and 404 age-matched controls and 134 mothers of cases and controls were genotyped to explore polymorphisms in genes of the estrogen metabolism pathway: CYP1B1 (c.1294C>G, rs1056836), CYP3A4 (c.-392A>G, rs2740574), CYP3A5 (c.219-237G>A, rs776746), GSTM1/GSTT1 deletions, and SULT1A1 (c.638G>A, rs9282861; and c.667A>G, rs1801030). Logistic regression was used to calculate the odds ratios (OR) with 95% confidence intervals (CIs), and unconditional logistic regression was used to estimate adjusted odds ratios (aORs) by ethnicity. Because of multiple testing, p values < 0.01 were significant after Bonferroni correction. SULT1A1 (c.638G>A) was associated to infant acute lymphoblastic leukemia and acute myeloid leukemia (AML) risk in males (additive model: aOR = 0.52; 95% CI: 0.29–0.95, p = 0.03; dominant model: aOR = 2.18; 95% CI: 1.17–4.05, p = 0.01, respectively). CYP1B1 polymorphism was associated with a decreased risk of AML either for non-white or female children (additive model: OR = 0.24; 95% CI: 0.08–0.76, p < 0.01; additive model: aOR = 0.27; 95% CI: 0.08–0.89, p = 0.03, respectively). Since polymorphisms of Cytochrome P450 genes presented gender-specific risk associations, we also investigated their expression. CYP1B1 was not expressed in 57.1% of EAL cases, and its expression varied by genotype, gender, and leukemia subtype. Maternal-fetal GSTT1 null genotype was associated with risk of EAL. This study shows that polymorphisms in genes of estrogen metabolism confer genetic susceptibility to EAL, mainly in males, and maternal susceptibility genes modify the risk for developing EAL in newborns.
Biallelic mutations in BRCA1 cause a new Fanconi anemia subtype.

UNLABELLED Deficiency in BRCA-dependent DNA interstrand crosslink (ICL) repair is intimately connected to breast cancer susceptibility and to the rare developmental syndrome Fanconi anemia. Bona fide Fanconi anemia proteins, BRCA2 (FANCD1), PALB2 (FANCN), and BRIP1 (FANCJ), interact with BRCA1 during ICL repair. However, the lack of detailed phenotypic and cellular characterization of a patient with biallelic BRCA1 mutations has precluded assignment of BRCA1 as a definitive Fanconi anemia susceptibility gene. Here, we report the presence of biallelic BRCA1 mutations in a woman with multiple congenital anomalies consistent with a Fanconi anemia-like disorder and breast cancer at age 23. Patient cells exhibited deficiency in BRCA1 and RAD51 localization to DNA-damage sites, combined with radial chromosome formation and hypersensitivity to ICL-inducing agents. Restoration of these functions was achieved by ectopic introduction of a BRCA1 transgene. These observations provide evidence in support of BRCA1 as a new Fanconi anemia gene (FANCS). SIGNIFICANCE We establish that biallelic BRCA1 mutations cause a distinct FA-S, which has implications for risk counselling in families where both parents harbor BRCA1 mutations. The genetic basis of hereditary cancer susceptibility syndromes provides diagnostic information, insights into treatment strategies, and more accurate recurrence risk counseling to families.
Midodrine Versus Albumin in the Prevention of Paracentesis-Induced Circulatory Dysfunction in Cirrhotics: A Randomized Pilot Study

OBJECTIVES:Intravenous albumin has been used to prevent paracentesis-induced circulatory dysfunction (PICD) in cirrhotics; however, its use is costly and controversial. Splanchnic arterial vasodilatation is primarily responsible for PICD. There are no reports of use of midodrine in the prevention of PICD. In this pilot study, we evaluated midodrine and albumin in the prevention of PICD.METHODS:Forty patients with cirrhosis underwent therapeutic paracentesis with midodrine or albumin in a randomized controlled trial at a tertiary center. Effective arterial blood volume was assessed by plasma renin activity.RESULTS:Plasma renin activity at baseline and at 6 days after paracentesis did not differ in the two groups (43.18 ± 10.73 to 45.90 ± 8.59 ng/mL/h, P= 0.273 in the albumin group and 44.44 ± 8.44 to 41.39 ± 10.21 ng/mL/h, P= 0.115 in the midodrine group). Two patients had an increase in plasma renin activity of more than 50% from baseline in the albumin group, and none in the midodrine group. A significant increase in 24-h urine volume and urine sodium excretion was noted in the midodrine group. Midodrine therapy was cheaper than albumin therapy.CONCLUSIONS:The study suggests that midodrine may be as effective as albumin in preventing PICD in cirrhotics, but at a fraction of the cost, and can be administered orally. Midodrine also resulted in an increase in 24-h urine volume and sodium excretion.
A Head-Driven Approach to Incremental and Parallel Generation of Syntactic Structures

This paper describes the construction of syntactic structures within an incremental multi-level and parallel generation system. Incremental and parallel generation imposes special requirements upon syntactic description and processing. A head-driven grammar represented in a unification-based formalism is introduced which satisfies these demands. Furthermore the basic mechanisms for the parallel processing of syntactic segments are presented.