Miracle-dz/UniFAR-FTUs huggingface dataset:
To Be Connected, or Not to Be Connected: That is the Minimum Inefficiency Subgraph Problem

We study the problem of extracting a selective connector for a given set of query vertices Q subset of V in a graph G = (V,E). A selective connector is a subgraph of G which exhibits some cohesiveness property, and contains the query vertices but does not necessarily connect them all. Relaxing the connectedness requirement allows the connector to detect multiple communities and to be tolerant to outliers. We achieve this by introducing the new measure of network inefficiency and by instantiating our search for a selective connector as the problem of finding the minimum inefficiency subgraph. We show that the minimum inefficiency subgraph problem is NP-hard, and devise efficient algorithms to approximate it. By means of several case studies in a variety of application domains (such as human brain, cancer, and food networks), we show that our minimum inefficiency subgraph produces high-quality solutions, exhibiting all the desired behaviors of a selective connector.
A Preliminary Note on the Morphology of the Corpus Striatum and the Origin of the Neopallium.

will be revealed. The ventral parts of the hemisphere consist of solid masses of grey matter forming the paraterminal body (P.B.) and the basal nucleus of the lowlier vertebrates, for which I shall adopt Arieins Kappers's term "palaeostriatum. " The rest of the section consists of pallium containing a column of cortical cells, every part of which is in unbroken continuity with the rest. In the inner wall the cells of the cortical column (HIP.) are densely packed to form the hippocampal formation, as yet undifferentiated into a definite fascia dentata and hippocampus sensu stricto. In the roof of the hemisphere the cells become more loosely packed (at the point marked b), and the hippocampus passes without any such sudden break (such as is seen
A group-delivered self-management program reduces spasticity in people with multiple sclerosis: A randomized, controlled pilot trial

Background Spasticity affects more than 80% of people with multiple sclerosis (MS), affecting activity, participation, and quality of life. Based on an international guideline, an MS spasticity group education and stretching program, MS Spasticity: Take Control (STC), has been developed. Objective The objective of this paper is to determine whether STC with home stretching is associated with greater changes in spasticity than usual care (UC), consisting of an illustrated stretching booklet and home stretching but without group instruction or support, in people with MS. Methods Ambulatory MS patients with self-reported spasticity interfering with daily activities were randomized to STC or UC. Individuals completed questionnaires regarding MS, spasticity, walking, fatigue and mood, and physical measures of spasticity and walking. Results Thirty-eight of 40 participants completed both assessments. Mean total score and scores on two subscales of the MS Spasticity Scale-88 improved more with STC than with UC (p < 0.03). There was no significant change in the Modified Ashworth Scale in either group. Mean scores on the Modified Fatigue Impact Scale, the Beck Depression Inventory-II, and the physical component of the Multiple Sclerosis Impact Scale-29 showed statistically and clinically significant improvements in the STC group only. Conclusions Participation in STC improved self-reported impact of spasticity more than UC and provided encouraging improvements in other measures.
Comparison of functional antagonism between isoproterenol and M2 muscarinic receptors in guinea pig ileum and trachea.

The ability of the M2 muscarinic receptor to mediate an inhibition of the relaxant effects of forskolin and isoproterenol was investigated in guinea pig ileum and trachea. In some experiments, trachea was first treated with 4-diphenylacetoxy-N-methylpiperidine (4-DAMP) mustard to inactivate M3 receptors. The contractile response to oxotremorine-M was measured subsequently in the presence of both histamine (10 microM) and isoproterenol (10 nM). Under these conditions, [[2-[(diethylamino)methyl]-1-piperidinyl]acetyl]-5, 11-dihydro-6H-pyrido[2,3b]-[1,4]benzodiazepine-6-one (AF-DX 116) antagonized the contractile response to oxotremorine-M in a manner consistent with an M3 mechanism. However, when the same experiment was repeated using forskolin (4 microM) instead of isoproterenol, the response to oxotremorine-M exhibited greater potency and was antagonized by AF-DX 116 in a manner consistent with an M2 mechanism. We also measured the effects of pertussis toxin treatment on the ability of isoproterenol to inhibit the contraction elicited by a single concentration of either histamine (0.3 microM) or oxotremorine-M (40 nM) in both the ileum and trachea. Pertussis toxin treatment had no significant effect on the potency of isoproterenol for inhibiting histamine-induced contractions in the ileum and trachea. In contrast, pertussis toxin treatment enhanced the relaxant potency of isoproterenol against oxotremorine-M-induced contractions in the ileum but not in the trachea. Also, pertussis toxin treatment enhanced the relaxant potency of forskolin against oxotremorine-M-induced contractions in the ileum and trachea. We investigated the relaxant potency of isoproterenol when very low, equi-effective (i.e., 20-34% of maximal response) concentrations of either histamine or oxotremorine-M were used to elicit contraction. Under these conditions, isoproterenol exhibited greater relaxant potency against histamine in the ileum but exhibited similar relaxant potencies against histamine and oxotremorine-M in the trachea. Following 4-DAMP mustard treatment, a low concentration of oxotremorine-M (10 nM) had no contractile effect in either the ileum or trachea. Nevertheless, in 4-DAMP mustard-treated tissue, oxotremorine-M (10 nM) reduced the relaxant potency of isoproterenol against histamine-induced contractions in the ileum, but not in the trachea. We conclude that in the trachea the M2 receptor mediates an inhibition of the relaxant effects of forskolin, but not isoproterenol, and the decreased relaxant potency of isoproterenol against contractions elicited by a muscarinic agonist relative to histamine is not due to activation of M2 receptors but rather to the greater contractile stimulus mediated by the M3 receptor compared with the H1 histamine receptor.
Cerebral Perivascular Spaces Visible on Magnetic Resonance Imaging: Development of a Qualitative Rating Scale and its Observer Reliability

Background: Perivascular spaces (PVS) are an important component of cerebral small vessel disease (SVD), several inflammatory disorders, hypertension and blood-brain barrier breakdown, but are difficult to quantify. A recent international collaboration of SVD experts has highlighted the need for a robust, easy-to-use PVS rating scale for the effective investigation of the diagnostic and prognostic significance of PVS. The purpose of the current study was to develop and extend existing PVS scales to provide a more comprehensive scale for the measurement of PVS in the basal ganglia, centrum semiovale and midbrain, and to test its intra- and inter-rater agreement, assessing reasons for discrepancy. Methods: We reviewed previously published PVS scales, including site of PVS assessed, rating method, and size and morphological criteria. Retaining key features, we devised a more comprehensive scale in order to improve the reliability of PVS rating. Two neuroradiologists tested the new scale in MRI brain scans of 60 patients from two studies (stroke, ageing population), chosen to represent a full range of PVS, and demonstrating concomitant features of SVD such as lacunes and white matter hyperintensities. We rated basal ganglia, centrum semiovale, and midbrain PVS. Basal ganglia and centrum semiovale PVS were rated 0 (none), 1 (1-10), 2 (11-20), 3 (21-40) and 4 (>40), and midbrain PVS were rated 0 (none visible) or 1 (visible). We calculated kappa statistics for rating, assessed consistency in use of PVS categories (Bhapkar test) and reviewed sources of discrepancy. Results: Intra- and inter-rater kappa statistics were highest for basal ganglia PVS (range 0.76-0.87 and 0.8-0.9, respectively) than for centrum semiovale PVS (range 0.68-0.75 and 0.61-0.8, respectively) or midbrain PVS (inter-rater range 0.51-0.52). Inter-rater consistency was better for basal ganglia compared to centrum semiovale PVS (Bhapkar statistic 2.49-3.72, compared to 6.79-21.08, respectively). Most inter-rater disagreements were due to very faint PVS, coexisting extensive white matter hyperintensities (WMH) or the presence of lacunes. Conclusions: We developed a more inclusive and robust visual PVS rating scale allowing rating of all grades of PVS severity on structural brain imaging. The revised PVS rating scale has good observer reliability for basal ganglia and centrum semiovale PVS, best for basal ganglia PVS, and moderate reliability for midbrain PVS. Agreement is influenced by PVS severity and the presence of background features of SVD. The current scale can be used in further studies to assess the clinical implications of PVS.
HHV-6A Infection of Endometrial Epithelial Cells Induces Increased Endometrial NK Cell-Mediated Cytotoxicity

Background: We have recently reported the presence of Human herpesvirus-6A (HHV-6A) DNA in the 43% of endometrial epithelial cells from primary idiopathic infertile women, with no positivity in fertile women. To investigate the possible effect of HHV-6A infection in endometrial (e)NK cells functions, we examined activating/inhibitory receptors expressed by eNK cells and the corresponding ligands on endometrial cells during HHV-6A infection. Methods: Endometrial biopsies and uterine flushing samples during the secretory phase were obtained from 20 idiopathic infertile women and twenty fertile women. HHV-6A infection of endometrial epithelial cells was analyzed by Real-Time PCR, immunofluorescence and flow cytometry. eNKs receptors and endometrial ligands expression were evaluated by immunofluorescence and flow cytometry. Results: We observed the presence of HHV-6A infection (DNA, protein) of endometrial epithelial cells in the 40% of idiopathic infertile women. The eNK from all the subgroups expressed high levels of NKG2D and NKG2A receptors. Functional studies showed that NKG2D activating receptor and FasL are involved in the acquired cytotoxic function of eNK cells during HHV-6A infection of endometrial epithelial cells. In the presence of HHV-6A infection, eNK cells increased expression of CCR2, CXCR3 and CX3CR1 chemokine receptors (p = 0.01) and endometrial epithelial cells up-modulated the corresponding ligands: MCP1 (Monocyte chemotactic protein 1, CCL2), IP-10 (Interferon gamma-induced protein 10, CXCL10) and Eotaxin-3 (CCL26). Conclusion: Our results, for the first time, showed the implication of eNK cells in controlling HHV-6A endometrial infection and clarify the mechanisms that might be implicated in female idiopathic infertility.
Serum and Pleural Fluid Procalcitonin in Predicting Bacterial Infection in Patients with Parapneumonic Effusion

This study evaluated the value of procalcitonin (PCT) levels in pleural effusion to differentiate the etiology of parapneumonic effusion (PPE). Forty-one consecutive PPE patients were enrolled and were divided into bacterial and non-bacterial PPE. Blood and pleural effusion samples were collected for PCT measurement on admission and analyzed for diagnostic evaluation. PCT of pleural fluid was significantly increased in the bacterial PPE group (0.24 ng/mL) compared to the non-bacterial PPE group (0.09 ng/mL), but there was no significant difference for serum PCT. A PCT concentration of pleural fluid >0.174 ng/mL (best cut-off value) was considered positive for a diagnosis of bacterial PPE (sensitivity, 80%; specificity, 76%; AUC, 0.84). Pleural effusion PCT in the bacterial PPE is significantly different from those of the non-bacterial PPE and control groups, so the diagnostic use of PCT still warrants further investigation.
Gremlin – a putative pathogenic player in progressive renal disease

Progressive renal fibrosis is the end process of renal injury leading to kidney failure. Current therapies for chronic renal failure aim to slow this process but fail to halt its progression. As the mechanisms involved in glomerulosclerosis and tubulointerstitial fibrosis are unravelled, potential treatments for this growing clinical problem should emerge. Gremlin, a developmental regulator of bone morphogenetic proteins (BMPs), has recently been implicated in processes such as glomerulosclerosis, tubulointerstitial fibrosis and cellular hypertrophy, and may represent a novel therapeutic target in progressive renal diseases.
Incentivizing outsourced computation

We describe different strategies a central authority, the boss, can use to distribute computation to untrusted contractors. Our problem is inspired by volunteer distributed computing projects such as SETI@home, which outsource computation to large numbers of participants. For many tasks, verifying a task's output requires as much work as computing it again; additionally, some tasks may produce certain outputs with greater probability than others. A selfish contractor may try to exploit these factors, by submitting potentially incorrect results and claiming a reward. Further, malicious contractors may respond incorrectly, to cause direct harm or to create additional overhead for result-checking. We consider the scenario where there is a credit system whereby users can be rewarded for good work and fined for cheating. We show how to set rewards and fines that incentivize proper behavior from rational contractors, and mitigate the damage caused by malicious contractors. We analyze two strategies: random double-checking by the boss, and hiring multiple contractors to perform the same job. We also present a bounty mechanism when multiple contractors are employed; the key insight is to give a reward to a contractor who catches another worker cheating. Furthermore, if we can assume that at least a small fraction h of the contractors are honest (1% - 10%), then we can provide graceful degradation for the accuracy of the system and the work the boss has to perform. This is much better than the Byzantine approach, which typically assumes h > 60%.
Real‐Time Earthquake Monitoring during the Second Phase of the Deep Fault Drilling Project, Alpine Fault, New Zealand

ABSTRACT The Deep Fault Drilling Project (DFDP) is a multinational scientific drilling effort to study the evolution, structure, and seismogenesis of the Alpine fault, New Zealand, via in situ measurements of fault rock properties. The second phase of drilling (DFDP‐2), undertaken in the Whataroa Valley in late 2014, was intended to intersect the Alpine fault at a depth of around 1 km. In conjunction with the drilling and on‐site science activities, a real‐time seismic monitoring scheme and traffic‐light response protocol were established to detect, locate, and if necessary respond to seismicity within 30 km of the drill site. This network was operated around the clock between late August 2014 and early January 2015, and we detected and located 493 earthquakes of M L 0.6–4.2. None of these earthquakes occurred within 3 km of the drill site, and nor did any of the seismicity detected require changes to drilling operations. The monitoring was undertaken using open‐source software operated by an international team of 16 seismologists (including eight postgraduate students) working in 7 institutions and 3 countries to provide rapid on‐ and off‐site manual checking and relocating of events. The team’s standard response time between detection and final location was less than 30 min under normal background seismicity conditions and up to 1 hr during swarm activity and for low‐priority, distant (≥30 km epicentrally from the drill site) earthquakes. This article documents the methodology, infrastructure, protocols, outcomes, and key lessons of this monitoring.
Estimation of Quasi-Stiffness of the Human Hip in the Stance Phase of Walking

This work presents a framework for selection of subject-specific quasi-stiffness of hip orthoses and exoskeletons, and other devices that are intended to emulate the biological performance of this joint during walking. The hip joint exhibits linear moment-angular excursion behavior in both the extension and flexion stages of the resilient loading-unloading phase that consists of terminal stance and initial swing phases. Here, we establish statistical models that can closely estimate the slope of linear fits to the moment-angle graph of the hip in this phase, termed as the quasi-stiffness of the hip. Employing an inverse dynamics analysis, we identify a series of parameters that can capture the nearly linear hip quasi-stiffnesses in the resilient loading phase. We then employ regression analysis on experimental moment-angle data of 216 gait trials across 26 human adults walking over a wide range of gait speeds (0.75–2.63 m/s) to obtain a set of general-form statistical models that estimate the hip quasi-stiffnesses using body weight and height, gait speed, and hip excursion. We show that the general-form models can closely estimate the hip quasi-stiffness in the extension (R2 = 92%) and flexion portions (R2 = 89%) of the resilient loading phase of the gait. We further simplify the general-form models and present a set of stature-based models that can estimate the hip quasi-stiffness for the preferred gait speed using only body weight and height with an average error of 27% for the extension stage and 37% for the flexion stage.
What are the dominant cytokines in early rheumatoid arthritis?

Purpose of review Rheumatoid arthritis is a systemic disease of evolving immune dysregulation that culminates in joint destruction and disability. The principle by which pro-inflammatory cytokines may be therapeutically targeted to abrogate disease is well established, but has yet to translate into reliable cures for patients. Emerging insights into cytokine-mediated pathobiology during rheumatoid arthritis development are reviewed, and their implications for future treatment strategies considered. Recent findings Accumulating data highlight cytokine perturbations before the clinical onset of rheumatoid arthritis. Some of these have now been linked to the arthritogenic activation of autoantibodies and associated pain and bone destruction in affected joints. These observations suggest cytokines may trigger the transition from systemic immunity to arthritis. Cytokine exposure could furthermore ‘prime’ synovial stromal cells to perpetuate a dominant pro-inflammatory environment. By facilitating cross-talk between infiltrating immune cells and even sustaining ectopic lymphoid structure development in some cases, cytokine interplay ultimately underpins the failure of arthritis to resolve. Summary Successful therapeutic stratification will depend upon an increasingly sophisticated appreciation of how dominant players amongst cytokine networks vary across time and anatomical space during incipient rheumatoid arthritis. The prize of sustained remission for all patients justifies the considerable effort required to achieve this understanding.
Deliverable 6.6 Report on the role winter convection in controlling the basin-scale C budget

is a contribution to T6.2. 4: Development of CIBM and evaluation of parameterisations. CIBM will be run in selected regions with T-S-profiles and external met-forcing from our basin-models. Its predictions will be used to optimise the 'biological' parameterisation of convection. This work will be informed by fieldwork undertaken in WP’s 2&4 on the METEOR convection cruise. The CIBM, thus, serves as a benchmark for checking the quality of the parameterisation. These parameterisations will then be implemented in the ¼ coupled physical-biological models of basin to quantify the role of the winter biomass in terms of the carbon- or CO2-budget in comparison to 'conventional' models.
Home enteral nutrition after minimally invasive esophagectomy can improve quality of life and reduce the risk of malnutrition.

BACKGROUND AND OBJECTIVES The potential benefits of home enteral nutrition (HEN) and the effects of HEN on quality of life (QOL) after esophagectomy remain unclear. The aim was to investigate the effect of 3 months HEN on health related QOL and nutritional status of esophageal cancer patients who were preoperatively malnourished. METHODS AND STUDY DESIGN 142 malnourished (PG-SGA stage B or C) patients with esophageal cancer were assigned to receive Ivor Lewis minimally invasive esophagectomy (MIE group) with laparoscopic jejunal feeding tube placement or open esophagectomy (OE group) with nasojejunal feeding tube placement. After discharge, patients in the MIE group received HEN with 500-1000 kcal/d for 3 months, while the OE group patients did not receive HEN, as nasojejunal feeding tubes had been removed. QLQ-C30 and PG-SGA questionnaires were used to evaluate the QOL and the risk of malnutrition. RESULTS 67 patients were enrolled in the MIE group and 75 patients were enrolled in the OE group. Symptoms related to fatigue, nausea, vomiting, pain, and appetite loss were significantly decreased in the patients treated with 3 months HEN. Similarly, patients treated with 3 months HEN had a lower risk of malnutrition than patients did not receive HEN (PG-SGA score, 5.7 vs 7.9, p<0.01). More patients in the MIE group (received 3 months HEN) were able to complete postoperative chemoradiotherapy than patients in the OE group (p<0.01). CONCLUSIONS MIE and subsequent treatment with 3 months HEN can improve the QOL and reduce the risk of malnutrition in preoperatively malnourished patients.
Low-Power Wireless ECG Acquisition and Classification System for Body Sensor Networks

A low-power biosignal acquisition and classification system for body sensor networks is proposed. The proposed system consists of three main parts: 1) a high-pass sigma delta modulator-based biosignal processor (BSP) for signal acquisition and digitization, 2) a low-power, super-regenerative on-off keying transceiver for short-range wireless transmission, and 3) a digital signal processor (DSP) for electrocardiogram (ECG) classification. The BSP and transmitter circuits, which are the body-end circuits, can be operated for over 80 days using two 605 mAH zinc-air batteries as the power supply; the power consumption is 586.5 μW. As for the radio frequency receiver and DSP, which are the receiving-end circuits that can be integrated in smartphones or personal computers, power consumption is less than 1 mW. With a wavelet transform-based digital signal processing circuit and a diagnosis control by cardiologists, the accuracy of beat detection and ECG classification are close to 99.44% and 97.25%, respectively. All chips are fabricated in TSMC 0.18-μm standard CMOS process.
High-fidelity modeling of MEMS resonators. Part I. Anchor loss mechanisms through substrate

A computational model is developed for the prediction of wave propagation in the substrate of a MEMS resonator to study energy loss mechanisms from the vibrating beams to the substrate, viz., anchor loss. The model employs a modified classical Fourier transform method under periodic excitations at the anchor area. The present substrate model, when applied to a typical commercially fabricated substrate, estimates that the anchor loss of an ends-anchored resonator with its center frequency of 50 MHz can reach as high as 0.05% in terms of equivalent damping ratio. Anchor loss versus resonator center frequency is assessed by varying the beam dimension, which predicts that anchor loss increases a hundredfold for every tenfold increase in resonator center frequency in the case of two ends-anchored beam resonators. The substrate model has been integrated into a coupled beam-substrate-electrostatics model and validated with experimental data. Development of the detailed coupled-physics model and its validation is presented in Part II as a companion paper.