Miracle-dz/UniFAR-FTUs huggingface dataset:
EFFECT OF REGIONAL CHARACTERISTICS ON CRASH INJURY 1 SEVERITY OF LOCAL BUSES USING A HIERARCHICAL ORDERED 2 MODEL 3 4

1 As the importance of public transportation increases, the management of bus-involved crashes 2 has become a crucial issue for traffic safety. Currently, however, there are relatively few studies 3 on crash severity for buses in Korea. The present study investigated factors influencing injury 4 severity of local bus-involved crashes identified based on using commercial vehicle crash data 5 for a five-year period from 2010 to 2014 in Korea. In order to determine unobserved regional 6 effects on crash severity, a hierarchical ordered model was applied to the analysis. Individual 7 crash characteristics were set to lower level variables and regional characteristics were adopted 8 as upper level variables. At the lower level, the factors affecting severity of local bus injury 9 included vehicle speed, vehicle age, road alignment, surface status, road class and traffic light 10 installation as found in previous studies. At the upper level, ratio the factors included road 11 pavement, emergent medical environment, traffic rate of compliance and ratio of elderly in the 12 community. There was a 5.1% unobserved variation between regions from the intraclass 13 correlation analysis. The validity of a hierarchical model for local bus crashes was verified by 14 applying the same model on other types of long-distance buses and it appeared that there were no 15 regional effects. This study found a regional effect for local bus crash severity and thus this 16 factor is important when developing prevention plans to reduce local bus crashes. These results 17 contribute to the study of traffic safety. 18 19
Graphene-based Josephson junction single photon detector

We propose to use graphene-based Josephson junctions (gJjs) to detect single photons in a wide electromagnetic spectrum from visible to radio frequencies. Our approach takes advantage of the exceptionally low electronic heat capacity of monolayer graphene and its constricted thermal conductance to its phonon degrees of freedom. Such a system could provide high sensitivity photon detection required for research areas including quantum information processing and radio-astronomy. As an example, we present our device concepts for gJj single photon detectors in both the microwave and infrared regimes. The dark count rate and intrinsic quantum efficiency are computed based on parameters from a measured gJj, demonstrating feasibility within existing technologies.
Remote Ischemic Postconditioning for Ischemic Stroke: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Background: Remote ischemic postconditioning (RIPostC) appears to protect distant organs from ischemia-reperfusion injury (IRI). However, cerebral protection results have remained inconclusive. In the present study, a meta-analysis was performed to compare stroke patients with and without RIPostC. Methods: CNKI, WanFang, VIP, CBM, PubMed, and Cochrane Library databases were searched up to July 2016. Data were analyzed using both fixed-effects and random-effects models by Review Manager. For each outcome, risk ratio (RR) and mean difference (MD) with 95% confidence interval (CI) were calculated. Results: A total of 13 randomized controlled trials that enrolled a total of 794 study participants who suffered from or are at risk for brain IRI were selected. Compared with controls, RIPostC significantly reduced the recurrence of stroke or transient ischemic attacks (RR = 0.37; 95% CI: 0.26–0.55; P < 0.00001). Moreover, it can reduce the levels of the National Institutes of Health Stroke Scale score (MD: 1.96; 95% CI: 2.18–1.75; P < 0.00001), modified Rankin Scale score (MD: 0.73; 95% CI: 1.20–0.25; P = 0.00300), and high-sensitivity C-reactive protein (MD: 4.17; 95% CI: 4.71–3.62; P < 0.00001) between the two groups. There was no side effect of RIPostC using tourniquet cuff around the limb on ischemic stroke treating based on different intervention duration. Conclusion: The present meta-analysis suggests that RIPostC might offer cerebral protection for stroke patients suffering from or are at risk of brain IRI.
The Aquila Digital Community The Aquila Digital Community

: In this study, we examined how sensitivity to oil changes in combination with environmental stressors in Fundulus grandis embryos. We exposed embryos (< 24 hours post fertilization) to a range of High Energy Water Accommodated Fraction (HEWAF) concentrations (0-50 ppb total polycyclic aromatic hydrocarbons) made from Macondo oil in conjunction with various environmental conditions (temperature: 20, 30°C; salinity: 3, 7, 30 practical salinity units (PSU); DO: 2, 6 mg/L). Endpoints included mortality, hatching rates, and expression of cytochrome p450 1a and 1c ( cyp1a , cyp1c ) in hatched larvae. There was 100% mortality for all fish under the 2 ppm dissolved oxygen (DO) regimes. For the 6 mg/L DO treatments, mortality and mean lethal time were generally higher in the 30°C treatments versus the 20°C treatments. Oil increased mortality in fish exposed to the highest concentration in the 20-3-6 (°C-PSU-mg/L), 25-7-6, and 30-30-6 conditions. Hatching was driven by environmental conditions, with oil exposure only having a significant impact on hatching in the 25-7-6 and 30-30-6 groups at the highest HEWAF exposure. Expression of cyp1a was upregulated in most treatment groups versus the controls, with cyp 1 c expression exhibiting a similar pattern. These data suggest interactive effects among temperature, salinity, and PAHs, highlighting a need to further assess the effects of oil exposure under various environmental conditions. This article is protected by copyright. All rights reserved
Spatial and Temporal Variation in the Growth and Production of Ephoron leukon (Ephemeroptera:Polymitarcyidae)

Variation in growth rates, maximum nymphal sizes, densities, and production estimates of Ephoron leukon (Ephemeroptera:Polymitarcyidae) were investigated at two sites over a 3-yr period on the South River, Virginia. Ephoron leukon is univoltine with development confined to a short (3-4 mo) period during the summer followed by a long (8-9 mo) egg diapause. The short growing season combined with a high degree of developmental syncrony makes this species ideal for comparative field studies. Relative growth rates ranged from 0.014 to 0.028 mg/mg/day and significant differences were observed between sites and years. Spatial differences in growth rates were explained by between-site differences in thermal regime but between-year differences were not. Differences in average densities between years may have been important in explaining annual differences in growth rates. Maximum nymphal weights averaged between 3.22 and 4.78 mg (AFDM) and were significantly higher at the downstream site for all three years. Differences were attributed to faster growth rates combined with relatively small differences in cohort production intervals. Average densities ranged from 117 to 602 individuals/m2, and significant differences were observed between sites and years, with annual differences being most pronounced. Average densities were related more to initial densities than to mortality rates and thus factors governing number of eggs laid and hatching success were responsible for annual differences in densities. The data suggest that hatching success may have been influenced by the thermal regime of the previous winter. Annual production ranged from 398 to 2857 mg/m2/yr and differences were significant between sites and years. Much of the between-site variation in production estimates was explained by differences in maximum nymphal weight, while differences in mean densities explained much of the annual variation in production.
Decrease of Perivascular Adipose Tissue Browning Is Associated With Vascular Dysfunction in Spontaneous Hypertensive Rats During Aging

Functional perivascular adipose tissue (PVAT) is necessary to maintain vascular physiology through both mechanical support and endocrine or paracrine ways. PVAT shows a brown adipose tissue (BAT)-like feature and the browning level of PVAT is dependent on the anatomic location and species. However, it is not clear whether PVAT browning is involved in the vascular tone regulation in spontaneously hypertensive rats (SHRs). In the present study, we aimed to illustrate the effect of aging on PVAT browning and subsequent vasomotor reaction in SHRs. Herein we utilized histological staining and western blot to detect the characteristics of thoracic PVAT (tPVAT) in 8-week-old and 16-week-old SHR and Wistar-Kyoto (WKY) rats. We also detected vascular reactivity analysis to determine the effect of tPVAT on vasomotor reaction during aging. The results showed that tPVAT had a similar phenotype to BAT, including smaller adipocyte size and positive uncoupling protein-1 (UCP1) staining. Interestingly, the tPVAT of 8-week-old SHR showed increased BAT phenotypic marker expression compared to WKY, whereas the browning level of tPVAT had a more dramatic decrease from 8 to 16 weeks of age in SHR than age-matched WKY rats. The vasodilation effect of tPVAT on aortas had no significant difference in 8-week-old WKY and SHR, whereas this effect is obviously decreased in 16-week-old SHR compared to WKY. In contrast, tPVAT showed a similar vasoconstriction effect in 8- or 16-week-old WKY and SHR rats. Moreover, we identified an important vasodilator adenosine, which regulates adipocyte browning and may be a potential PVAT-derived relaxing factor. Adenosine is dramatically decreased from 8 to 16 weeks of age in the tPVAT of SHR. In summary, aging is associated with a decrease of tPVAT browning and adenosine production in SHR rats. These may result in attenuated vasodilation effect of the tPVAT in SHR during aging.
Learning Temporal Dynamics for Video Super-Resolution: A Deep Learning Approach

Video super-resolution (SR) aims at estimating a high-resolution video sequence from a low-resolution (LR) one. Given that the deep learning has been successfully applied to the task of single image SR, which demonstrates the strong capability of neural networks for modeling spatial relation within one single image, the key challenge to conduct video SR is how to efficiently and effectively exploit the temporal dependence among consecutive LR frames other than the spatial relation. However, this remains challenging because the complex motion is difficult to model and can bring detrimental effects if not handled properly. We tackle the problem of learning temporal dynamics from two aspects. First, we propose a temporal adaptive neural network that can adaptively determine the optimal scale of temporal dependence. Inspired by the inception module in GoogLeNet [1], filters of various temporal scales are applied to the input LR sequence before their responses are adaptively aggregated, in order to fully exploit the temporal relation among the consecutive LR frames. Second, we decrease the complexity of motion among neighboring frames using a spatial alignment network that can be end-to-end trained with the temporal adaptive network and has the merit of increasing the robustness to complex motion and the efficiency compared with the competing image alignment methods. We provide a comprehensive evaluation of the temporal adaptation and the spatial alignment modules. We show that the temporal adaptive design considerably improves the SR quality over its plain counterparts, and the spatial alignment network is able to attain comparable SR performance with the sophisticated optical flow-based approach, but requires a much less running time. Overall, our proposed model with learned temporal dynamics is shown to achieve the state-of-the-art SR results in terms of not only spatial consistency but also the temporal coherence on public video data sets. More information can be found in http://www.ifp. illinois.edu/~dingliu2/videoSR/.
Trabeculectomy with mitomycin for open-angle glaucoma in phakic vs pseudophakic eyes after phacoemulsification.

OBJECTIVE To determine whether previous phacoemulsification adversely affects surgical prognosis of trabeculectomy with mitomycin for open-angle glaucoma. METHODS The study is a retrospective, consecutive, comparative case series. At 2 clinical centers, we reviewed 226 medical records of eyes with open-angle glaucoma undergoing initial trabeculectomy, including 175 phakic eyes (phakic group) and 51 pseudophakic eyes that had previously undergone phacoemulsification with superior conjunctival incision (pseudophakic group). Primary outcome was the probability of success after trabeculectomy. Surgical failure was defined as an additional glaucoma surgery or 1 of the following 3 criteria: intraocular pressure (IOP) of 21 mm Hg or greater (A); IOP of 18 mm Hg or greater (B); and IOP of 15 mm Hg or greater (C). Multivariable analysis was performed using the Cox proportional hazards model. RESULTS The mean follow-up period was 37.5 months. The probability of success for criteria A, B, and C at 1 and 3 years in the phakic vs the pseudophakic group was 97.8% and 92.6%, respectively, vs 78.6% and 65.1%, respectively, for criterion A (P < .001); 92.9% and 81.3%, respectively, vs 72.8% and 63.7%, respectively, for criterion B (P = .004); and 73.1% and 54.2%, respectively, vs 53.1% and 38.4%, respectively, for criterion C (P = .009). The multivariable model confirmed that pseudophakia independently contributes to surgical failure (criterion A relative risk, 4.59 [P < .001]; criterion B, 2.88 [P = .004]; and criterion C, 2.02 [P = .009]). The pseudophakic group required more postoperative laser suture lysis (P = .01). CONCLUSION Previous phacoemulsification is a prognostic factor for surgical failure of trabeculectomy with mitomycin for open-angle glaucoma.
An in vitro verification of strength estimation for moving an 125I source during implantation in brachytherapy

Abstract This study aims to demonstrate the feasibility of a method for estimating the strength of a moving brachytherapy source during implantation in a patient. Experiments were performed under the same conditions as in the actual treatment, except for one point that the source was not implanted into a patient. The brachytherapy source selected for this study was 125I with an air kerma strength of 0.332 U (μGym2h−1), and the detector used was a plastic scintillator with dimensions of 10 cm × 5 cm × 5 cm. A calibration factor to convert the counting rate of the detector to the source strength was measured and then the accuracy of the proposed method was investigated for a manually driven source. The accuracy was found to be under 10% when the shielding effect of additional needles for implantation at other positions was corrected, and about 30% when the shielding was not corrected. Even without shielding correction, the proposed method can detect dead/dropped source, implantation of a source with the wrong strength, and a mistake in the number of the sources implanted. Furthermore, when the correction was applied, the achieved accuracy came close to within 7% required to find the Oncoseed 6711 (125I seed with unintended strength among the commercially supplied values of 0.392, 0.462 and 0.533 U).
Neural Progenitors in the Developing Neocortex of the Northern Tree Shrew (Tupaia belangeri) Show a Closer Relationship to Gyrencephalic Primates Than to Lissencephalic Rodents

The neocortex is the most complex part of the mammalian brain and as such it has undergone tremendous expansion during evolution, especially in primates. The majority of neocortical neurons originate from distinct neural stem and progenitor cells (NPCs) located in the ventricular and subventricular zone (SVZ). Previous studies revealed that the SVZ thickness as well as the abundance and distribution of NPCs, especially that of basal radial glia (bRG), differ markedly between the lissencephalic rodent and gyrencephalic primate neocortex. The northern tree shrew (Tupaia belangeri) is a rat-sized mammal with a high brain to body mass ratio, which stands phylogenetically mid-way between rodents and primates. Our study provides – for the first time – detailed data on the presence, abundance and distribution of bRG and other distinct NPCs in the developing neocortex of the northern tree shrew (Tupaia belangeri). We show that the developing tree shrew neocortex is characterized by an expanded SVZ, a high abundance of Pax6+ NPCs in the SVZ, and a relatively high percentage of bRG at peak of upper-layer neurogenesis. We further demonstrate that key features of tree shrew neocortex development, e.g., the presence, abundance and distribution of distinct NPCs, are closer related to those of gyrencephalic primates than to those of ferret and lissencephalic rodents. Together, our study provides novel insight into the evolution of bRG and other distinct NPCs in the neocortex development of Euarchontoglires and introduces the tree shrew as a potential novel model organism in the area of human brain development and developmental disorders.
Neural Models for Reasoning over Multiple Mentions Using Coreference

Many problems in NLP require aggregating information from multiple mentions of the same entity which may be far apart in the text. Existing Recurrent Neural Network (RNN) layers are biased towards short-term dependencies and hence not suited to such tasks. We present a recurrent layer which is instead biased towards coreferent dependencies. The layer uses coreference annotations extracted from an external system to connect entity mentions belonging to the same cluster. Incorporating this layer into a state-of-the-art reading comprehension model improves performance on three datasets – Wikihop, LAMBADA and the bAbi AI tasks – with large gains when training data is scarce.
Searching for Clinically Relevant Biomarkers in Geriatric Oncology

Ageing, which is associated with a progressive decline and functional deterioration in multiple organ systems, is highly heterogeneous, both inter- and intraindividually. For this, tailored-made theranostics and optimum patient stratification become fundamental, when decision-making in elderly patients is considered. In particular, when cancer incidence and cancer-related mortality and morbidity are taken into account, elderly patient care is a public health concern. In this review, we focus on oncogeriatrics and highlight current opportunities and challenges with an emphasis on the unmet need of clinically relevant biomarkers in elderly cancer patients. We performed a literature search on PubMed and Scopus databases for articles published in English between 2000 and 2017 coupled to text mining and analysis. Considering the top insights, we derived from our literature analysis that information knowledge needs to turn into knowledge growth in oncogeriatrics towards clinically relevant biomarkers, cost-effective practices, updated educational schemes for health professionals (in particular, geriatricians and oncologists), and awareness of ethical issues. We conclude with an interdisciplinary call to omics, geriatricians, oncologists, informatics, and policy-makers communities that Big Data should be translated into decision-making in the clinic.
Lysosome enlargement during inhibition of the lipid kinase PIKfyve proceeds through lysosome coalescence

ABSTRACT Lysosomes receive and degrade cargo from endocytosis, phagocytosis and autophagy. They also play an important role in sensing and instructing cells on their metabolic state. The lipid kinase PIKfyve generates phosphatidylinositol-3,5-bisphosphate to modulate lysosome function. PIKfyve inhibition leads to impaired degradative capacity, ion dysregulation, abated autophagic flux and a massive enlargement of lysosomes. Collectively, this leads to various physiological defects, including embryonic lethality, neurodegeneration and overt inflammation. The reasons for such drastic lysosome enlargement remain unclear. Here, we examined whether biosynthesis and/or fusion-fission dynamics contribute to swelling. First, we show that PIKfyve inhibition activates TFEB, TFE3 and MITF, enhancing lysosome gene expression. However, this did not augment lysosomal protein levels during acute PIKfyve inhibition, and deletion of TFEB and/or related proteins did not impair lysosome swelling. Instead, PIKfyve inhibition led to fewer but enlarged lysosomes, suggesting that an imbalance favouring lysosome fusion over fission causes lysosome enlargement. Indeed, conditions that abated fusion curtailed lysosome swelling in PIKfyve-inhibited cells. Summary: PIKfyve inhibition causes lysosomes to coalesce, resulting in fewer, enlarged lysosomes; TFEB-mediated lysosome biosynthesis does not contribute to swelling.
Hyperandrogenic athletes: performance differences in elite-standard 200m and 800m finals

ABSTRACT The purpose of this study was to examine whether the difference in elite-standard track and field performance between women athletes with and without hyperandrogenism reaches the 10–12% difference in performance between men and women, using only results from elite-standard track and field final competitions. Officially available data from two hyperandrogenic women (Caster Semenya and Dutee Chand) were compared with the characteristic performance of 200m and 800m elite-standard finals. The finishing times of Caster Semenya, before her ineligibility to compete in 2009 and after the suspension of the 2011 IAAF Hyperandrogenism Regulations were found to be respectively 1.24% and 1.49% faster than the predicted performance in 800m finals. When compared with the result of the second classified, the difference was respectively 0.65% and 2.08%. The analysis of the finishing times of Dutee Chand did not lead to any conclusions due to the lack of available data. The present study indicates that the percentage difference in performance between women with and women without hyperandrogenism does not reach the 3% difference requested by the Court of Arbitration for Sport for the reinstatement of the Hyperandrogenism Regulations, neither does it reach the 10% accepted range of difference in performance between men and women.
Laboratory experiments on dynamo action and magnetically triggered flow instabilities

Magnetic fields of planets, stars and galaxies are generated by self-excitation in moving electrically conducting fluids. Once produced, magnetic fields can play an active role in cosmic structure formation by destabilizing rotational flows that would be otherwise hydrodynamically stable. For a long time, both hydromagnetic dynamo action as well as magnetically triggered flow instabilities had been the subject of purely theoretical research. Meanwhile, however, the dynamo effect has been observed in large-scale liquid sodium experiments in Riga, Karlsruhe and Cadarache. In this paper, we summarize the results of liquid metal experiments devoted to the dynamo effect and various magnetic instabilities such as the helical and the azimuthal magnetorotational instability and the Tayler instability. We discuss in detail our plans for a precession-driven dynamo experiment and a large-scale Tayler-Couette experiment using liquid sodium, and on the prospects to observe magnetically triggered instabilities of flows with positive shear.