Miracle-dz/UniFAR-FTUs huggingface dataset:
A note on technical change in banking: the case of European savings banks

Using a Fourier flexible form cost function methodology, technical progress is estimated for a large sample of European savings banks between 1989 and 1997. On average, technical progress has reduced savings banks total costs by around 3.4% per annum. Since the European savings banks industry is characterized by technology sharing arrangements, a test is made to determine whether technical change is positively related to bank size. The estimates identify two important features of how technical progress has effected European savings banks' costs. First, costs reductions arising from technical change diminish between 1989 and 1997. Second, technical progress has a bigger impact on reducing large savings banks' costs, chiefly because of its influence on input prices, that is, non-neutral technical change increases systematically with size. This suggests that large savings banks have greater flexibility in reducing costs in response to technical progress, implying that technology sharing arrangements have not led to uniform reductions in banks' total cost. Rather, large savings banks are market leaders and small banks market followers. Since larger banks benefit more from technical progress this may be an important factor promoting consolidation in the European savings banks industry.
High-dose midazolam infusion for refractory status epilepticus

Objective: This study compares 2 treatment protocols allowing low vs high continuous IV midazolam (cIV-MDZ) doses. Methods: We compared adults with refractory status epilepticus treated with a protocol allowing for high-dose cIV-MDZ (n = 100; 2002–2011) with those treated with the previous lower-dose cIV-MDZ (n = 29; 1996–2000). We collected data on baseline characteristics, cIV-MDZ doses, seizure control, hospital course, and outcome. Results: Median maximum cIV-MDZ dose was 0.4 mg/kg/h (interquartile range [IQR] 0.2, 1.0) for the high-dose group and 0.2 mg/kg/h (IQR 0.1, 0.3) for the low-dose group (p < 0.001) with similar duration of infusion. Median time from status epilepticus onset to cIV-MDZ start was 1 day (IQR 1, 3) for the high-dose group and 2 days (IQR 1, 5) for the low-dose group (p = 0.016). “Withdrawal seizures” (occurring within 48 hours of discontinuation of cIV-MDZ) were less frequent in the high-dose group (15% vs 64%, odds ratio 0.10, 95% confidence interval 0.03–0.27). “Ultimate cIV-MDZ failure” (patients requiring change to a different cIV antiepileptic medication) and hospital complications were not different between groups. Hypotension was more frequent with higher cIV-MDZ doses but was not associated with worse outcome. Discharge mortality was lower in the high-dose group (40% vs 62%, odds ratio 0.34, 95% confidence interval 0.13–0.92 in multivariate analysis). Conclusions: High-dose cIV-MDZ treatment of refractory status epilepticus can be performed safely, is associated with a lower seizure rate after cIV-MDZ discontinuation, and may be associated with lower mortality than traditional lower-dose protocols. Classification of evidence: This study provides Class III evidence that midazolam at higher infusion rates is associated with a reduction in seizure recurrence within 48 hours after discontinuation and may be associated with lower mortality.
Repetitive regret, depression, and anxiety: findings from a nationally representative survey

Past research has established a connection between regret (negative emotions connected to cognitions about how past actions might have achieved better outcomes) and both depression and anxiety. In the present research, the relations between regret, repetitive thought, depression, and anxiety were examined in a nationally representative telephone survey. Although both regret and repetitive thought were associated with general distress, only regret was associated with anhedonic depression and anxious arousal. Further, the interaction between regret and repetitive thought (i.e., repetitive regret) was highly predictive of general distress but not of anhedonic depression nor anxious arousal. These relations were strikingly consistent across demographic variables such as sex, race/ethnicity, age, education, and income.
VSLS contribution to stratospheric chlorine

Y. Mébarki, V. Catoire, G. Berthet, N. Huret, and C. Robert Laboratoire de Physique et Chimie de l’Environnement et de l’Espace (LPC2E), UMR 6115 CNRS – Université d’Orléans, 45071 Orléans cedex 2, France Received: 11 July 2009 – Accepted: 21 July 2009 – Published: 29 July 2009 Correspondence to: V. Catoire (valery.catoire@cnrs-orleans.fr) Published by Copernicus Publications on behalf of the European Geosciences Union.
Progression of periodontitis in a sample of regular and irregular compliers under maintenance therapy: a 3-year follow-up study.

BACKGROUND To our knowledge, prospective studies (matched for sex, smoking, and diabetes) that investigated the influence of compliance in the progression of periodontitis and tooth loss in periodontal maintenance therapy (PMT) programs were not previously reported. METHODS A total of 58 regular complier (RC) and 58 erratic complier (EC) individuals were recruited from a prospective cohort with 238 patients under PMT and matched by sex, diabetes, and smoking habits. A full-mouth periodontal examination that included bleeding on probing (BOP), probing depths (PDs), clinical attachment levels, and number of teeth were determined at all PMT visits during a 3-year interval. The influence of variables of interest was tested through multivariate logistic regression. RESULTS The progression of periodontitis and tooth loss was significantly lower among RC compared to EC patients. A higher progression of periodontitis was observed among EC patients who smoked. The final logistic model for the progression of periodontitis in the RC group included smoking (odds ratio [OR]: 4.2) and >30% of sites with BOP (OR: 2.8), and the final logistic model for the progression of periodontitis in the EC group included smoking (OR: 7.3), >30% of sites with BOP (OR: 3.2), PDs of 4 to 6 mm in 10% of sites (OR: 3.5), diabetes (OR: 1.9), and number of lost teeth (OR: 3.1). CONCLUSIONS RC patients presented a lower progression of periodontitis and tooth loss compared to EC patients. This result highlighted the influence of the pattern of compliance in maintaining a good periodontal status. Moreover, important risk variables such as smoking and diabetes influenced the periodontal status and should be considered when determining the risk profile and interval time for PMT visits.
Cache Invalidation Patterns in Shared-Memory Multiprocessors

The cache invalidation patterns of several parallel applications are analyzed. The results are based on multiprocessor simulations with 8, 16, and 32 processors. To provide deeper insight into the observed invalidation behavior the invalidations observed in the simulations are linked to the high-level objects causing them in the programs. To predict what the invalidation patterns would look like beyond 32 processors, a classification scheme for data objects found in parallel programs is proposed. The classification scheme provides a powerful conceptual tool to reason about the invalidation patterns of parallel applications. Results indicate that it should be possible to scale well-written parallel programs to a large number of processors without an explosion in invalidation traffic. At the same time, the invalidation patterns are such that directory-based schemes with just a few pointers per entry can be very effective. The variations in invalidation behavior with different cache line sizes are discussed. The results indicate that cache line sizes in the 32-byte range yield the lowest data and invalidation traffic. >
Gender and Marital Satisfaction: A Replication with a Sample of Spouses from the Christian Church (Disciples of Christ)

In a subsample of 57 husbands and 120 wives who had participated in a larger study of retention of church members, an effect size of 0.23 was found between gender and marital satisfaction as measured by the Kansas Marital Satisfaction Scale. The results are consistent with previous findings of a gender effect, the “his and hers” marriage.
MOBILISING YOUNG CITIZENS IN THE UK: A content analysis of youth and issue websites

This article reviews recent thinking and practice on the issue of youth mobilization in the United Kingdom. Developing young people's sense of civic efficacy has been shown to be the key to facilitating civic engagement. However, different approaches and online mobilization strategies have been adopted by top-down government or parliament-supported projects, and by non-governmental or ‘issue’ organizations. To address the question of whether UK mobilization sites are making the most of the internet to facilitate youth efficacy 20 youth and issue mobilization websites were analysed looking at content, design and interactivity. The study found that most top-down youth sites, such as youth parliaments and forums, lacked appealing, relevant content and a clear purpose; their aim was to generically ‘involve’ young people without a set of specific reasons and benefits that would motivate young users. Youth portals were an exception to the rule as they provided users with comprehensive, accessible and relevant information and tools. NGO sites were much more empowering and strategic in their agenda and reach, with slick, comprehensive and appealing pages, although quite focused on citizens already engaged with the issues. Overall, the study finds clear signs of a move towards the politics of everyday life and the model of the citizen-consumer. Political organizations providing promotional material, participation tools and practical tips that link to young visitors' lifeworld are more likely to succeed in boosting their sense of efficacy. However, that raises important questions about the gravitas of such online activities in traditional political terms.
News We Can Use: An Audience Perspective on the Tabloidisation of News in the United States

AbstractIn the United States, television news is where the issue of tabloidisation is most loudly debated, as news merges into the countless talk shows and syndicated “reality” programming. While critics often place the blame on the journalism profession itself, I focus on the audience drive toward tabloidisation, critiquing both the uncritical celebration of the “active” audience, and the view that audiences are simply mindless recipients of whatever journalists feed them. Using data from a small study of news audiences, I argue that we must understand the value of dramatic, narrative news in everyday life. At the same time, I argue that the storytelling news style, characterised by disconnected, highly personal narratives, is in danger of replacing rational, considered, and critical analysis in news. In particular, young people are becoming less interested in news, and less critical of the techniques typical of tabloid style. I conclude that we must strive to develop a journalism that could embrace tabl.
Age Differences in Subjective Well-Being across Adulthood: The Roles of Savoring and Future Time Perspective

Prior research indicates there are age differences in subjective well-being during adulthood, but research on age differences in savoring (up-regulating positive emotion) is lacking. Using an online survey (N = 218, adults 18–77), this study investigated age differences in subjective well-being and savoring, and whether future time perspective (perceived amount of time left to live) mediated associations between age and savoring. Results indicated a nonlinear effect of age on subjective well-being. Although savoring was associated with subjective well-being, age was not directly associated with savoring. However, an indirect effect of future time perspective linking age and savoring indicated that younger adults reported more perceived time left in life and those perceiving more time left in life reported greater savoring. Overall, the results do not support savoring as a direct explanatory mechanism for age differences in subjective well-being, but future time perspective appears to play an important role in indirect associations between age and savoring.
Pathobiology of HIV/SIV‐associated changes in secondary lymphoid tissues

Acquired immunodeficiency syndrome (AIDS) is principally a disease of lymphoid tissues (LTs), due to the fact that the main target cell of human immunodeficiency virus (HIV) is the CD4+ T lymphocyte that primarily resides within organs of the immune system. The impact of HIV infection on secondary LTs, in particular lymph nodes, is critical to delineate, as these immune organs are the principal sites for initiating and facilitating immune responses and are critical for lymphocyte homeostatic maintenance and survival. The underlying structural elements of LTs, fibroblastic reticular cell (FRC) network, not only form the architectural framework for these organs, but also play in integral role in the production and storage of cytokines needed for T‐cell survival. There is an interdependent relationship between the FRC stromal network and CD4+ T lymphocytes for their survival and maintenance that is progressively disrupted during HIV disease. HIV infection results in profound pathological changes to LTs induced by persistent chronic immune activation and inflammation that leads to progressive collagen deposition and fibrosis disrupting and damaging the important FRC network. In this review, I focus on the process, mechanisms, and the implications of pathological damage to important secondary LTs, combining what we have learned from HIV‐infected individuals as well as the invaluable knowledge gained from studies in non‐human primate simian immunodeficiency virus infection models.
Deficiency of Src family kinases p59/61hck and p58c-fgr results in defective adhesion-dependent neutrophil functions

Cross-linking of the neutrophil-beta 2- or beta 3-related leukocyte response integrins by extracellular matrix (ECM) proteins or monoclonal antibodies (mAb) stimulates cytoskeletal rearrangement leading to cell spreading and respiratory burst. Tyrosin phosphorylation of a variety of proteins and activation of the Src family kinases within polymorphonuclear leukocytes (PMN) have recently been implicated in the intracellular signaling pathways generated by leukocyte integrins (Yan, S.R., L. Fumagalli, and G Berton. 1995. J. Inflammation. 45:217-311.) To directly test whether these functional responses are dependent on the Src family kinases p59/61hck and p58c-fgr, we examined adhesion- dependent respiratory burst in PMNs isolated from hck -/-, fgr -/-, and hck -/- fgr -/- knockout mice. Purified bone marrow PMNS from wild-type mice released significant amounts of O2- when adherent to fibrinogen-, fibronectin-, or collagen-coated surfaces, in the presence of activating agents such as tumor necrosis factor (TNF) or formyl- methionyl-leucyl-phenylalanine, as described for human PMNs. PMNs from hck-/-fgr-/- double-mutant mic, however, failed to respond. This defect was specific for integrin signaling, since respiratory burst was normal in hck-/-fgr-/-PMNs stimulated by immune complexes or PMA. Stimulation of respiratory burst was observed in TNF-primed wild-type PMN plated on surfaces coated with murine intracellular adhesion molecule-1 (ICAM-1), while hck-/-fgr-/- PMNs, failed to respond. Direct cross-linking of the subunits of beta 2 and beta 2 integrins by surface-bound mAbs was elicited O2- production by wild-type PMNs, while the double-mutant hck- /-fgr-/- cells failed to respond. Photomicroscopy and cell adhesion assays revealed that the impaired functional responses of hck-/-fgr-/- PMNs were caused by defective spreading and tight adhesion on either ECM protein- or mAb-coated surfaces. In contrast, hck-/-or fgr-/-single mutant cells produced O2- at levels equivalent to wild-type cells on ECM protein, murine ICAM-1, and antiintegrin mAb-coated surfaces. Hence, either p59/61 hck and p 58c-fgr is required for signaling through leukocyte beta 2 and beta 3 integrins leading to PMN spreading and respiratory burst. This is the first direct genetic evidence of the importance of Src family kinases in integrin signaling within leukocytes, and it is also the best example of overlapping function between members of this gene family within a defined signal transduction pathway.
Contrasting association of circulating sCD14 with insulin sensitivity in non-obese and morbidly obese subjects.

SCOPE In experimental studies, moderate to high concentrations of sCD14 (serum cluster of differentiation 14 protein) prevent lipopolysaccharide (LPS)-induced systemic inflammation, while low concentrations may promote inflammation. Given that metabolic endotoxemia is thought to initiate high-fat diet-induced insulin resistance, we explored the association between sCD14 concentrations and insulin sensitivity in humans. METHODS AND RESULTS Healthy non-obese (n = 12, BMI 26 ± 5y), obese (n = 11, BMI 33.45 ± 3.2) and morbidly obese participants (n = 38, BMI 45 ± 7) underwent measurement of body composition (dual energy X-ray absorptiometry) and a hyperinsulinemic-euglycemic clamp to measure insulin sensitivity (M value). Circulating sCD14 concentrations were measured by ELISA. Non-obese participants had lower circulating sCD14 concentrations compared to obese (p = 0.03). Circulating sCD14 concentrations were positively associated with percent body fat, waist circumference and white blood cell count and negatively associated with insulin sensitivity. In contrast, circulating sCD14 were positively associated with insulin sensitivity in morbidly obese participants. In regression analysis, insulin sensitivity (r = 0.52, p = 0.004) and fasting triglycerides (r = 0.49, p = 0.005) contributed independently to circulating sCD14 variance after controlling for age, sex and BMI in these morbidly obese subjects. CONCLUSION These findings suggest that circulating sCD14 concentrations, through its compensatory (in non-obese subjects) or buffering role (in morbidly obese subjects), could exert an important role in modulating insulin sensitivity.
DNA Damage Persistence as Determinant of Tumor Sensitivity to the Combination of Topo I Inhibitors and Telomere-Targeting Agents

Purpose: We previously reported that the G-quadruplex (G4) ligand RHPS4 potentiates the antitumor activity of camptothecins both in vitro and in tumor xenografts. The present study aims at investigating the mechanisms involved in this specific drug interaction. Experimental Design: Combination index test was used to evaluate the interaction between G4 ligands and standard or novel Topo I inhibitors. Chromatin immunoprecipitation was performed to study the presence at telomeres of various types of topisomerase, while immunolabeling experiments were performed to measure the activation of DNA damage both in vitro and in tumor xenografts. Results: We report that integration of the Topo I inhibitor SN-38, but not the Topo II poison doxorubicin with telomere-based therapy is strongly effective and the sequence of drug administration is critical in determining the synergistic interaction, impairing the cell ability to recover from drug-induced cytotoxicity. The synergistic effect of this combination was also observed by using novel camptothecins and, more interestingly, mice treated with ST1481/RHPS4 combination showed an inhibition and delay of tumor growth as well as an increased survival. The study of the mechanism(s) revealed that treatment with G4 ligands increased Topo I at the telomeres and the functional relevance of this observation was directly assessed by showing that standard and novel camptothecins stabilized DNA damage both in vitro and in xenografts. Conclusions: Our results demonstrate an outstanding efficacy of Topo I inhibitors/G4 ligands combination, which likely reflects an enhanced and persistent activation of DNA damage response as a critical determinant of the therapeutic improvement. Clin Cancer Res; 17(8); 2227–36. ©2011 AACR.
Dynamics of projective morphisms having identical canonical heights

Let ϕ, ψ:ℙN → ℙN be morphisms of degree at least 2 whose canonical heights ĥϕ and ĥψ are identical. We draw various conclusions about the Green functions, Julia sets, and canonical local heights of ϕ and ψ. We use this information to completely characterize ϕ and ψ in the following cases: (i) ϕ and ψ are polynomial maps in one variable; (ii) ϕ is the dth‐power map; (iii) ϕ is a Lattès map.
Glucosamine-Induced Endoplasmic Reticulum Stress Promotes ApoB100 Degradation: Evidence for Grp78-Mediated Targeting to Proteasomal Degradation

Objective—To investigate the role of glucosamine-mediated endoplasmic reticulum (ER) stress and Grp78 (BiP) in the intracellular degradation of apolipoprotein B100 (apoB100) in cultured hepatocytes. Methods and Results—Glucosamine treatment (2.5 to 10 mmol/L) of HepG2 cells increased levels of the ER chaperones, 78-kDa glucose-regulated protein (Grp78) and Grp94, in a dose-dependent manner and led to significant decreases in both cellular and secreted apoB100 by up to 97% (P<0.01). In contrast, no changes were observed in ER resident (ER60, PTP-1B) or secretory (albumin, apoE) control proteins. Glucosamine-induced apoB degradation was similarly observed in primary hamster hepatocytes and McA-RH7777 cells. Glucosamine treatment led to reduced tranlocational efficiency of apoB100 in the ER and enhanced its ubiquitination and proteasomal degradation. Adenoviral overexpression of Grp78 also led to significantly decreased levels of newly synthesized apoB100 in a dose-dependent manner (P<0.01). Grp78-induced downregulation of apoB100 was sensitive to inhibition by the proteasome inhibitor, lactacystin, but not lysosomal protease inhibitors, E64 and leupeptin, suggesting that overexpression of Grp78 selectively induced proteasomal degradation of apoB100. Conclusion—These findings suggest that binding and retention by Grp78 may play a critical role in proteasomal targeting and the ER quality-control of misfolded apoB. Interaction with core lipoprotein lipids may facilitate apoB transport out of the ER by reducing Grp78-mediated ER retention.
Dynamical System Analysis of Reynolds Stress Closure Equations

In this paper, we establish the causality between the model coefficients in the standard pressure-strain correlation model and the predicted equilibrium states for homogeneous turbulence. We accomplish this by performing a comprehensive fixed point analysis of the modeled Reynolds stress and dissipation rate equations. The results from this analysis will be very useful for developing improved pressure-strain correlation models to yield observed equilibrium behavior.