Miracle-dz/UniFAR-FTUs huggingface dataset:
Pseudo-Triangulations - a Survey

A pseudo-triangle is a simple polygon with three convex vertices, and a pseudo-triangulation is a face-to-face tiling of a planar region into pseudo-triangles. Pseudo-triangulations appear as data structures in computational geometry, as planar bar-and-joint frameworks in rigidity theory and as projections of locally convex surfaces. This survey of current literature includes combinatorial properties and counting of special classes, rigidity theoretical results, representations as polytopes, straight-line drawings from abstract versions called combinatorial pseudo-triangulations, algorithms and applications of pseudo-triangulations.
A hybrid quality evaluation approach based on fuzzy inference system for medical video streaming over small cell technology

Small cell technology is expected to be an integral part of future 5G networks in order to meet the increasingly high user demands for traffic volume, frequency efficiency, and energy and cost reductions. Small cell networks can play an important role in enhancing the Quality of Service (QoS) and Quality of Experience (QoE) in m-health applications, and in particular, in medical video streaming. In this paper, we propose a hybrid medical QoE prediction model based on a Fuzzy Inference System (FIS) that correlates the network QoS (NQoS) and application QoS (AQoS) parameters to the QoE. The model is tested on the transmission of medical ultrasound video over small cell technology. The results show that the predicted QoE scores of our proposed model have a high correlation with the subjective scores of medical experts.
Nucleotide sequence of the ospAB operon of a Borrelia burgdorferi strain expressing OspA but not OspB

The nucleotide sequence of a 1.6-kb clone containing the gene for outer surface protein A (OspA) of a German strain (GO2) of Borrelia burgdorferi was determined. The deduced amino acid sequence showed a homology of 82% to the OspA molecules from three other B. burgdorferi strains. The best-conserved region was recognized at the 36-amino-terminal amino acids of OspA. OspB could not be identified in the strain investigated, probably because the nucleotide sequence of the ospAB operon prevented expression of the OspB gene.
The Smc5–Smc6 Complex Is Required to Remove Chromosome Junctions in Meiosis

Meiosis, a specialized cell division with a single cycle of DNA replication round and two consecutive rounds of nuclear segregation, allows for the exchange of genetic material between parental chromosomes and the formation of haploid gametes. The structural maintenance of chromosome (SMC) proteins aid manipulation of chromosome structures inside cells. Eukaryotic SMC complexes include cohesin, condensin and the Smc5–Smc6 complex. Meiotic roles have been discovered for cohesin and condensin. However, although Smc5–Smc6 is known to be required for successful meiotic divisions, the meiotic functions of the complex are not well understood. Here we show that the Smc5–Smc6 complex localizes to specific chromosome regions during meiotic prophase I. We report that meiotic cells lacking Smc5–Smc6 undergo catastrophic meiotic divisions as a consequence of unresolved linkages between chromosomes. Surprisingly, meiotic segregation defects are not rescued by abrogation of Spo11-induced meiotic recombination, indicating that at least some chromosome linkages in smc5–smc6 mutants originate from other cellular processes. These results demonstrate that, as in mitosis, Smc5-Smc6 is required to ensure proper chromosome segregation during meiosis by preventing aberrant recombination intermediates between homologous chromosomes.
A Plasmodium falciparum Transcriptional Cyclin-Dependent Kinase-Related Kinase with a Crucial Role in Parasite Proliferation Associates with Histone Deacetylase Activity

ABSTRACT Cyclin-dependent protein kinases (CDKs) are key regulators of the eukaryotic cell cycle and of the eukaryotic transcription machinery. Here we report the characterization of Pfcrk-3 (Plasmodium falciparum CDK-related kinase 3; PlasmoDB identifier PFD0740w), an unusually large CDK-related protein whose kinase domain displays maximal homology to those CDKs which, in other eukaryotes, are involved in the control of transcription. The closest enzyme in Saccharomyces cerevisiae is BUR1 (bypass upstream activating sequence requirement 1), known to control gene expression through interaction with chromatin modification enzymes. Consistent with this, immunofluorescence data show that Pfcrk-3 colocalizes with histones. We show that recombinant Pfcrk-3 associates with histone H1 kinase activity in parasite extracts and that this association is detectable even if the catalytic domain of Pfcrk-3 is rendered inactive by site-directed mutagenesis, indicating that Pfcrk-3 is part of a complex that includes other protein kinases. Immunoprecipitates obtained from extracts of transgenic parasites expressing hemagglutinin (HA)-tagged Pfcrk-3 by using an anti-HA antibody displayed both protein kinase and histone deacetylase activities. Reverse genetics data show that the pfcrk-3 locus can be targeted only if the genetic modification does not cause a loss of function. Taken together, our data strongly suggest that Pfcrk-3 fulfils a crucial role in the intraerythrocytic development of P. falciparum, presumably through chromatin modification-dependent regulation of gene expression.
Seamless Montage for Texturing Models

We present an automatic method to recover high‐resolution texture over an object by mapping detailed photographs onto its surface. Such high‐resolution detail often reveals inaccuracies in geometry and registration, as well as lighting variations and surface reflections. Simple image projection results in visible seams on the surface. We minimize such seams using a global optimization that assigns compatible texture to adjacent triangles. The key idea is to search not only combinatorially over the source images, but also over a set of local image transformations that compensate for geometric misalignment. This broad search space is traversed using a discrete labeling algorithm, aided by a coarse‐to‐fine strategy. Our approach significantly improves resilience to acquisition errors, thereby allowing simple and easy creation of textured models for use in computer graphics.
Comparative Time‐Resolved Photosystem II Chlorophyll a Fluorescence Analyses Reveal Distinctive Differences between Photoinhibitory Reaction Center Damage and Xanthophyll Cycle‐Dependent Energy Dissipation *

Abstract— The photosystem II (PSII) reaction center in higher plants is susceptible to photoinhibitory molecular damage of its component pigments and proteins upon prolonged exposure to excess light in air. Higher plants have a limited capacity to avoid such damage through dissipation, as heat, of excess absorbed light energy in the PSII light‐harvesting antenna. The most important pho‐toprotective heat dissipation mechanism, induced under excess light conditions, includes a concerted effect of the trans‐thylakoid pH gradient (ΔpH) and the carotenoid pigment interconversions of the xanthophyll cycle. Co‐incidentally, both the photoprotective mechanism and photoinhibitory PSII damage decrease the PSII chlorophyll a (Chi a) fluorescence yield. In this paper we present a comparative fluorescence lifetime analysis of the xanthophyll cycle‐ and photoinhibition‐dependent changes in PSII Chi a fluorescence. We analyze multifrequency phase and modulation data using both multicomponent exponential and bimodal Lorentzian fluorescence lifetime distribution models; further, the lifetime data were obtained in parallel with the steady‐state fluorescence intensity. The photoinhi‐bition was characterized by a progressive decrease in the center of the main fluorescence lifetime distribution from ∼2 ns to ∼0.5 ns after 90 min of high light exposure. The damaging effects were consistent with an increased nonra‐diative decay path for the charge‐separated state of the PSII reaction center. In contrast, the ΔpH and xanthophyll cycle had concerted minor and major effects, respectively, on the PSII fluorescence lifetimes and intensity (Gilmore et ah, 1996, Photosynth. Res., in press). The minor change decreased both the width and lifetime center of the longest lifetime distribution; we suggest that this change is associated with the ΔpH‐induced activation step, needed for binding of the deepoxidized xanthophyll cycle pigments. The major change increased the fractional intensity of a short lifetime distribution at the expense of a longer lifetime distribution; we suggest that this change is related to the concentration‐dependent binding of the deepoxidized xanthophylls in the PSII inner antenna. Further, both the photoinhibition and xanthophyll cycle mechanisms had different effects on the relationship between the fluorescence lifetimes and intensity. The observed differences between the xanthophyll cycle and photoinhibition mechanisms confirm and extend our current basic model of PSII exciton dynamics, structure and function.
Claims on demand – an initial demonstration of a system for automatic detection and polarity identification of context dependent claims in massive corpora

While discussing a concrete controversial topic, most humans will find it challenging to swiftly raise a diverse set of convincing and relevant claims that should set the basis of their arguments. Here, we demonstrate the initial capabilities of a system that, given a controversial topic, can automatically pinpoint relevant claims in Wikipedia, determine their polarity with respect to the given topic, and articulate them per the user's request.
MicroRNA Post-transcriptional Regulation of the NLRP3 Inflammasome in Immunopathologies

Inflammation has a crucial role in protection against various pathogens. The inflammasome is an intracellular multiprotein signaling complex that is linked to pathogen sensing and initiation of the inflammatory response in physiological and pathological conditions. The most characterized inflammasome is the NLRP3 inflammasome, which is a known sensor of cell stress and is tightly regulated in resting cells. However, altered regulation of the NLRP3 inflammasome is found in several pathological conditions, including autoimmune disease and cancer. NLRP3 expression was shown to be post-transcriptionally regulated and multiple miRNA have been implicated in post-transcriptional regulation of the inflammasome. Therefore, in recent years, miRNA based post-transcriptional control of NLRP3 has become a focus of much research, especially as a potential therapeutic approach. In this review, we provide a summary of the recent investigations on the role of miRNA in the post-transcriptional control of the NLRP3 inflammasome, a key regulator of pro-inflammatory IL-1β and IL-18 cytokine production. Current approaches to targeting the inflammasome product were shown to be an effective treatment for diseases linked to NLRP3 overexpression. Although utilizing NLRP3 targeting miRNAs was shown to be a successful therapeutic approach in several animal models, their therapeutic application in patients remains to be determined.
Xanthogranuloma of the sellar region diagnosed by frozen section

Abstract Xanthogranuloma (XG) of the sellar region is uncommon and is difficult to diagnose based on intraoperative frozen sections. This study is a case presentation and review of the literature, highlighting the need to explore underlying diseases in order to guarantee an accurate patient diagnosis. Herein, we presented the case of a 43-year-old woman who was afflicted with xanthogranuloma of the sellar region; the patient had a history of headache and lengthened menstrual cycles over the 6 months prior to presentation. Endocrinology tests revealed that the patient’s levels of prolactin were high and the MRI of the patient showed a clearly defined sellar mass. As a result, the patient was considered to have prolactinoma prior to undergoing surgery. The tumor was completely removed using a transsphenoidal approach, and intraoperative frozen section revealed histology similar to xanthogranuloma. When the tumor was removed by surgical operation, the patient’s visual field defects and headache were relieved. Although intraoperative frozen section should provide some guidance with regard to the diagnosis, a pathological study is conducted to confirm the actual diagnosis.
Lightweight closure conversion

We consider the problem of lightweight closure conversion, in which multiple procedure call protocols may coexist in the same code. A lightweight closure omits bindings for some of the free variables of the procedure that is represents. Flow analysis is used to match the protocol expected by each procedure and the protocol used at its possible call sites. We formulate the flow analysis as a deductive system that generates a labeled transition system and a set of constraints. We show that any solution to the constraints justifies the resulting transformation. Some of the techniques used are similar to those of abstract interpretation, but others appear to be novel.
H i Clouds in LITTLE THINGS Dwarf Irregular Galaxies

We identify 814 discrete H i clouds in 40 dwarf irregular galaxies from the LITTLE THINGS survey using an automated cloud-finding algorithm. The cloud masses range from ∼103 to 107 M⊙, have a surface density averaged over all of the clouds of ∼9.65 M⊙ pc−2, and constitute 2%–53% of the total H i mass of the host galaxy. For individual clouds, the mass including He varies with cloud radius as × and the internal velocity dispersion varies as × . The H i clouds tend to be in the outer regions of the galaxies, with 72% of the galaxies having more than 70% of their clouds outside one disk scale length and 32% of the galaxies having more than 50% of their clouds outside the radius encircling the H ii emission. Thirty-six percent of the clouds are essentially non-self-gravitating from H i alone, with a virial parameter that exceeds αvir ∼ 10, and 5% have αvir ≤ 2. We estimate the missing molecular mass, based on the total star formation rate and a typical molecular consumption time of 2 Gyr, as observed in CO-rich galaxies. The resulting molecular fraction has a value averaged over the galaxies of 0.23 and correlates with both the surface density of star formation and the fraction of H i clouds in the outer regions. We conclude that a significant fraction of the inner parts of these dwarf galaxy disks is in the form of dark molecular gas, and that this fraction could be high enough to make the inner disks mildly gravitationally unstable as a precursor to star formation.
A simultaneous perturbation stochastic approximation-based actor-critic algorithm for Markov decision processes

A two-timescale simulation-based actor-critic algorithm for solution of infinite horizon Markov decision processes with finite state and compact action spaces under the discounted cost criterion is proposed. The algorithm does gradient search on the slower timescale in the space of deterministic policies and uses simultaneous perturbation stochastic approximation-based estimates. On the faster scale, the value function corresponding to a given stationary policy is updated and averaged over a fixed number of epochs (for enhanced performance). The proof of convergence to a locally optimal policy is presented. Finally, numerical experiments using the proposed algorithm on flow control in a bottleneck link using a continuous time queueing model are shown.
An Empirical Evaluation of Thompson Sampling

Thompson sampling is one of oldest heuristic to address the exploration / exploitation trade-off, but it is surprisingly unpopular in the literature. We present here some empirical results using Thompson sampling on simulated and real data, and show that it is highly competitive. And since this heuristic is very easy to implement, we argue that it should be part of the standard baselines to compare against.
Care of children and adolescents with type 1 diabetes: a statement of the American Diabetes Association.

During recent years, the American Diabetes Association (ADA) has published detailed guidelines and recommendations for the management of diabetes in the form of technical reviews, position statements, and consensus statements. Recommendations regarding children and adolescents have generally been included as only a minor portion of these documents. For example, the most recent ADA position statement on “Standards of Medical Care for Patients With Diabetes Mellitus” (last revised October 2003) included “special considerations” for children and adolescents (1). Other position statements included age-specific recommendations for screening for nephropathy (2) and retinopathy (3) in children with diabetes. In addition, the ADA has published guidelines pertaining to certain aspects of diabetes that apply exclusively to children and adolescents, including care of children with diabetes at school (4) and camp (5) and a consensus statement on type 2 diabetes in children and adolescents (6). The purpose of this document is to provide a single resource on current standards of care pertaining specifically to children and adolescents with type 1 diabetes. It is not meant to be an exhaustive compendium on all aspects of the management of pediatric diabetes. However, relevant references are provided and current works in progress are indicated as such. The information provided is based on evidence from published studies whenever possible and, when not, supported by expert opinion or consensus (7). Several excellent detailed guidelines and chapters on type 1 diabetes in pediatric endocrinology texts exist, including those by the International Society of Pediatric and Adolescent Diabetes (ISPAD) (8), by the Australian Pediatric Endocrine Group (www.chw.edu/au/prof/services/endocrinology/apeg), in Lifshitz’s Pediatric Endocrinology (9–11), and by Plotnick and colleagues (12,13). Children have characteristics and needs that dictate different standards of care. The management of diabetes in children must take the major differences between children of various ages and …
Photosensitivity and epilepsy: a follow‐up study

To understand the evolution of photosensitivity and to evaluate if its disappearance is related to the response to anticonvulsant therapy, we performed a long‐term study of 42 patients (17 males, 25 females; age at onset 6 years 9 months, SD 5 years 2 months, range 5 years to 12 years 1 month) who had electroencephalography (EEG) evidence of photosensitive epilepsy. Of the patients, 36 were treated with valproate (VPA) monotherapy and four received VPA in combination with other antiepileptic drugs (AEDs), which were carbamazepine and lamotrigine. Two patients were given no drugs, but treated with stimuli avoidance. All patients were investigated with EEG by using intermittent photic stimulation. The photoparoxysmal response indicated the presence of photosensitivity. At the end of follow‐up, the photoparoxysmal response had disappeared in 25 patients. Thirty‐three patients became seizure‐free. Our study confirms that photosensitive epilepsy has a good prognosis for seizure control that is independent of the persistence or disappearance of photosensitivity.
Genome-wide association study identiﬁes nidogen 1 ( NID1 ) as a susceptibility locus to cutaneous nevi and melanoma risk

We conducted a genome-wide association study on the number of melanocytic nevi reported by 9136 individuals of European ancestry, with follow-up replication in 3581 individuals. We identiﬁed the nidogen 1 ( NID1 ) gene on 1q42 associated with nevus count (two linked single nucleotide polymorphisms with r 2 > 0.9: rs3768080 A allele associated with reduced count, P 5 6.5 3 10 2 8 ; and rs10754833 T allele associated with reduced count, P 5 1.5 3 10 2 7 ). We further determined that the rs10754833 [T] was associated with a decreased melanoma risk in 2368 melanoma cases and 7432 controls [for CT genotype: odds ratio (OR) 5 0.86, 95% conﬁdence interval (CI) 5 0.75–0.99, P 5 0.04; for TT genotype: OR 5 0.84, 95% CI 5 0.71–0.98, P 5 0.03]. Expression level of the NID1 locus was 2-fold higher for the rs10754833 T allele carriers than that with the CC genotype ( P 5 0.017) in the 87 HapMap CEU cell lines. The NID1 gene is a biologically plausible locus for nevogenesis and melanoma development, with decreased expression levels of NID1 in benign nevi ( P 5 3.5 3 10 2 6 ) and in primary melanoma ( P 5 4.6 3 10 2 4 ) compared with the normal skin.
Transfer of intestinal bacterial components to mammary secretions in the cow

Results from large multicentre epidemiological studies suggest an association between the consumption of raw milk and a reduced incidence of allergy and asthma in children. Although the underlying mechanisms for this association are yet to be confirmed, researchers have investigated whether bacteria or bacterial components that naturally occur in cow’s milk are responsible for modulating the immune system to reduce the risk of allergic diseases. Previous research in human and mice suggests that bacterial components derived from the maternal intestine are transported to breast milk through the bloodstream. The aim of our study was to assess whether a similar mechanism of bacterial trafficking could occur in the cow. Through the application of culture-independent methodology, we investigated the microbial composition and diversity of milk, blood and feces of healthy lactating cows. We found that a small number of bacterial OTUs belonging to the genera Ruminococcus and Bifidobacterium, and the Peptostreptococcaceae family were present in all three samples from the same individual animals. Although these results do not confirm the hypothesis that trafficking of intestinal bacteria into mammary secretions does occur in the cow, they support the existence of an endogenous entero-mammary pathway for some bacterial components during lactation in the cow. Further research is required to define the specific mechanisms by which gut bacteria are transported into the mammary gland of the cow, and the health implications of such bacteria being present in milk.