Miracle-dz/UniFAR-FTUs huggingface dataset:
Surgical outcomes following laparoscopic major hepatectomy for various liver diseases

Abstract The aim of the study was to report surgical outcomes (efficacy and safety) of laparoscopic major hepatectomy for various liver diseases. Although the number of laparoscopic liver resections has increased, expansion of laparoscopic major hepatic resection remains limited, mainly owing to the technical difficulties for the procedure as compared to open surgery. We describe our experiences with laparoscopic major hepatectomy for various liver diseases. We retrospectively reviewed the medical records of 192 patients who underwent laparoscopic major hepatectomy between October 2007 and March 2015 at Asan Medical Center, Korea. The mean age of the patients was 54 ± 11.6 years, and their mean body mass index was 23.5 kg/m2. The most common preoperative diagnosis was hepatocellular carcinoma (n = 82, 42.7%), followed by intrahepatic duct stones (n = 51, 26.6%). We performed 108 left hepatectomies, 55 right hepatectomies, 18 right posterior sectionectomies, 6 right anterior sectionectomies, 2 central bisectionectomies, and 3 donor right hepatectomies. The conversion rate was 1.6% (3 cases) due to bleeding, bile leakage, and uncontrolled hypercapnea during the operation. The mean operation time was 272 ± 80.2 minutes, and the mean estimated blood loss was 300.4 ± 252.2 mL. The mean postoperative hospital stay was 9.8 days. All resection margins were tumor-free in cases of malignant tumors. The morbidity rate was 3.1% (n = 6), including for case of biliary stricture. There were no deaths. Laparoscopic major hepatectomy, including donor hepatectomy, is a safe and feasible option for various liver diseases when careful selection criteria are used by a surgeon experienced with the relevant surgical techniques.
Hyaluronidase in the office: A necessity for every dermasurgeon that injects hyaluronic acid

Soft tissue augmentation plays an increasingly important role in the management of the aging face. The recent explosion of dermal filler use in aesthetic dermatology has brought with it the expected reporting of rare but significant side effects. These include the too‐superficial placement of product which can yield an undesirable bluish discoloration due to the Tyndall effect, the use of excessive product, persistent granulomatous foreign‐body reactions and, most significantly, the risk of injection necrosis.
Early structural changes in cartilage and bone are required for the attachment and invasion of inflamed synovial tissue during destructive inflammatory arthritis

Objective To elucidate the mechanisms involved in cartilage damage in an experimental model of rheumatoid arthritis (RA) by specifically addressing the time course of extracellular matrix degradation and the contribution of cell–matrix interactions for initiation and perpetuation of this process. Methods The human tumour necrosis factor (TNF) transgenic (hTNFtg) mouse model of RA was used to analyse the time course of pannus attachment to the cartilage and cartilage destruction, respectively, and crossed hTNFtg mice with interleukin (IL)-1−/− animals were used to investigate the role of IL-1 on these TNF-induced mechanisms in vivo. In addition, an in vitro attachment assay using synovial fibroblasts (SFs) from hTNFtg mice and freshly isolated articular cartilage was used to determine the role of proteoglycan loss in attachment of SFs and the role of the transmembrane heparan sulfate proteoglycan syndecan-4. Results In vivo analyses of hTNFtg mice showed that proteoglycan loss induced by IL-1 precedes and constitutes an important prerequisite for these processes as, in hTNFtg mice, IL-1 deficiency protected from the loss of cartilage proteoglycans and almost completely prevented the attachment and subsequent invasion of inflamed synovial tissue into cartilage. In vitro studies confirmed that loss of cartilage proteoglycans is required for attachment of SFs and that syndecan-4 is prominently involved in SF attachment and activation. Conclusions The results of this study suggest that the loss of cartilage proteoglycans is an early event in the course of destructive arthritis that facilitates the attachment of the inflamed synovial membrane and also initiates matrix degradation and inflammation through cell–matrix interactions.
Optimized MHealth Batch Verification for a Variant of DSA

With more and more research focusing on Health Care services, there is need for efficient authentication by use of digital signatures. Currently, the DSA is one of the most commonly used digital signature scheme. This paper proposes an Optimized Health Batch Verification Scheme on a variant of DSA. The proposed system is based on a new optimal DSA-type digital signature scheme, which is also proposed in this paper. Our scheme makes use of Small Exponents Test and Bucket Test subroutines for optimization. Performance evaluation shows that our scheme is significantly more efficient in batch verification of digital signatures, making it suitable for Health applications. The Scheme is secure against authentication threats, message integrity threats and replay attack threats.
Active control of vibration using a neural network

Feedforward control of sound and vibration using a neural network-based control system is considered, with the aim being to derive an architecture/algorithm combination which is capable of supplanting the commonly used finite impulse response filter/filtered-x least mean square (LMS) linear arrangement for certain nonlinear problems. An adaptive algorithm is derived which enables stable adaptation of the neural controller for this purpose, while providing the capacity to maintain causality within the control scheme. The algorithm is shown to be simply a generalization of the linear filtered-x LMS algorithm. Experiments are undertaken which demonstrate the utility of the proposed arrangement, showing that it performs as well as a linear control system for a linear control problem and better for a nonlinear control problem. The experiments also lead to the conclusion that more work is required to improve the predictability and consistency of the performance before the neural network controller becomes a practical alternative to the current linear feedforward systems.
Mild auditory cognitive impairment

auditory cognitive and behavioral functions ent-Related Potentials (ERPs) were studied by using DR and RAVLTTS otal 18 subjects were recruited (n= ; 16-27 weeks was used during ERP study. Subjects counted silently only target the target and standard stimuli were measured . The N100 and The P300 ERP component Higher amplitudes (4/6) and (4/6) of the N100 component were found. Shorter (1/6) and longer latencies (3/6) of the P300 component were in the pregnant group compared to the control group. scores of PAS, WCST, RAVLTDR and RAVLTTS among both hat there is mild auditory cognitive impairment during second Auditory cognition, Pregnancy, Standard stimuli,
Spatial extent of neighboring plants influences the strength of associational effects on mammal herbivory. Insights from a meta-analysis

There is high variability in the level of herbivory between individual plants from the same species with potential effects on population dynamics, community composition, and ecosystem structure and function. This variability can be partly explained by associational effects i.e. the impact of the presence of neighboring plants on the level of herbivory experienced by a focal plant, but it is still unclear how the spatial scale of plant neighborhood modulates foraging choice of herbivores; an inherently spatial process in itself. Using a meta-analysis, we investigated how spatial scale modifies associational effects on the susceptibility to browsing by herbivores with movement capacities similar to deer. From 2496 articles found in literature databases, we selected 46 studies providing a total of 168 differences of means in damage by herbivores or survival to woody plants (mostly) with and without neighboring plants. Spatial scales were reported as distance between plants or as plot size. We estimated the relationships between the effect sizes and spatial scale, type of associational effects and nature of the experiment using meta-analysis mixed models. The strength of associational effects declined with increasing plot size, regardless of the type of associational effects. Associational defences (i.e. decrease in herbivory for focal plants associated with unpalatable neighbors) had stronger magnitude than associational susceptibilities. The high remaining heterogeneity among studies suggests that untested factors modulate associational effects, such as nutritional quality of focal and neighboring plants, density of herbivores, timing of browsing, etc. Associational effects are already considered in multiple restoration contexts worldwide, but a better understanding of these relationships could improve their use in conservation, restoration and forest exploitation when browsing is a concern. This study is the first to investigate spatial patterns of associational effects across species and ecosystems, an issue that is essential to determine differential herbivory damages among plants.
The N-Terminal Region of Nurr1 (a.a 1–31) Is Essential for Its Efficient Degradation by the Ubiquitin Proteasome Pathway

NURR1/NR4A2 is an orphan nuclear receptor that is critical for the development and maintenance of mesencephalic dopaminergic neurons and regulates transcription of genes involved in the function of dopaminergic neurons directly via specific NGFI-B response elements (NBRE). and substantial data support a possible role of Nurr1 in the pathogenesis of Parkinson's disease (PD). Here we show that Nurr1 is degraded by the ubiquitin-proteasome pathway and determined that N-terminal region (a.a 1–31) of Nurr1 is essential for an efficient targeting of Nurr1 to degradation in the cell. Nurr1 Δ1–31 has a much longer half-life, and as a consequence its steady-state protein levels were higher, than full-length Nurr1 in the cell. Nurr1 Δ1–31 was as potent as Nurr1 full length in transcriptional luciferase reporter assays after normalization with the corresponding steady-state protein expression levels, either in trans-activation of NBRE or trans-repression of iNOS (inducible NO synthase) reporters. These results suggest that Nurr1 Δ1–31, because of longer persistence in the cell, can be a good candidate for gene and cell therapies in the treatment of PD.
Creatine phosphokinase activity and clinical symptomatology. A study in acute schizophrenic patients.

Serum creatine phosphokinase (CPK) and aldolase activities determined at admission and throughout hospitalization in 34 acute schizophrenic patients revealed 22 with increased activity of one or both enzymes. There was no difference in the percentage of paranoid and nonparanoid schizophrenic diagnoses in the patients with or without increased serum CPK or aldolase activities, nor were the magnitude of the increases in serum CPK or aldolase activities significantly different. The second-order factor scores of the Inpatient Multidimensional Psychiatric Scale also did not differentiate patients with elevated or normal serum enzyme activities. Results indicate the necessity of studying psychotic patients from the onset of gross psychotic symptoms with repeated study of both serum CPK and aldolase activities throughout hospitalization before subgroups of psychotic patients with and without increased serum CPK or aldolase activities may be reliably discriminated.
The association of weapon carrying and fighting on school property and other health risk and problem behaviors among high school students.

OBJECTIVE To examine the association between weapon carrying on school property and engaging in health risk and problem behaviors such as fighting and substance use on school property, fear of attending school, and victimization at school. DESIGN A complex 2-stage probability survey (Massachusetts Youth Risk Behavior Survey). SETTING High schools in Massachusetts. PARTICIPANTS Three thousand fifty-four high school students. MAIN OUTCOME MEASURE Number of days a weapon was carried on school property during the 30 days prior to the survey. RESULTS The prevalence of self-reported weapon carrying on school property was 15% among male students and 5% among female students (P < .001). Weapon carrying on school property was significantly (P < .001) associated with frequency of physical fights on school property (r = 0.26), being a victim of threat or injury with a weapon on school property (r = 0.27), being a victim of stolen or damaged goods on school property (r = 0.14), not attending school owing to fear (r = 0.15), and substance use while at school, including smoking cigarettes (r = 0.20), using chewing tobacco (r = 0.18), smoking marijuana (r = 0.24), and using alcohol (r = 0.29). The association between weapon carrying and alcohol use in school was higher among students who were afraid to come to school (r = 0.49) than among students who were not afraid (r = 0.28). Students who had engaged in same-sex sexual activity (P < .001) or had been offered, given, or sold illicit drugs at school (P < .001) were more likely to carry a weapon at school. Multiple regression analysis showed that male sex and the frequencies of physical fighting, being a victim of a threat or injury, drinking alcohol, smoking cigarettes, and being offered or sold an illicit drug while on school property accounted for 21% of the variance in weapon carrying in school. When weapon carrying was dichotomized and analyzed with logistic regression, a model containing age, male sex, lower academic achievement, days not attending school owing to fear, times threatened or injured with a weapon at school, frequency of fighting at school, cigarette smoking, alcohol use, and being offered or sold illicit drugs on school property correctly classified 91.83% of the students who did or did not carry weapons. CONCLUSIONS Weapon carrying at school was more strongly associated more with use of violence and the use of substances at school than with previous victimization and fear of attending school. However, there is a subgroup of students that seems to have been victimized at school, is afraid to come to school, is using alcohol at school, and is carrying weapons at school.
Technological viewpoints (frames) about electronic prescribing in physician practices

OBJECTIVE Physician practices may adopt and use electronic prescribing (eRx) in response to mandates, incentives, and perceived value of the technology. Yet, for the most part, diffusion has been limited and geographically confined, and even when adopted, use of eRx in many practices has been low. One explanation for this phenomenon is that decision-makers in the practices possess different technological viewpoints (frames) related to eRx and these frames have formed the basis for the adoption decision, expectations about the technology, and patterns of use. In this study eRx technological frames were examined. DESIGN Focus groups, direct observation, and semi-structured interviews were conducted with physicians, practice managers, nurses, and other medical staff. MEASUREMENTS Focus groups were observed, taped, transcribed, and analyzed to reveal themes. These themes guided the observational visits and subsequent interviews. A triangulation process was used to confirm the findings. RESULTS Seven frames emerged from the qualitative analysis ranging from positive to neutral to negative: (1) eRx as an efficiency and effectiveness enhancing tool; (2) eRx as the harbinger of new practices; (3) eRx as core to the clinical workflow; (4) eRx as an administrative tool; (5) eRx: the artifact; (6) eRx as a necessary evil; and (7) eRx as an unwelcome disruption. CONCLUSION Frames provide a unique perspective within which to explore the adoption and use of eRx and may explain why perceptions of value vary greatly. Some frames facilitate effective use of eRx while others impose barriers. Electronic prescribing can be viewed as a transitional technology on the path to greater digitization at the physician practice level. Understanding the impact of technological frames on the effectiveness of eRx use may provide lessons for the implementation of future health information technology innovations.
Adoptive Immunotherapy in Chimeras with Donor Lymphocytes

Allogeneic stem cell transplantation has a well-defined indication in the treatment of hematological malignancies. The beneficial immune effect of allogeneic marrow transplantation has long been known, but only recently have methods been developed to separate the graft-versus-leukemia (GVL) effect from graft-versus-host disease (GVHD). Animal experiments have shown that lymphocytes from the marrow donor can be transfused without causing severe GVHD if stable chimerism and tolerance is established. First clinical studies have been preformed in patients with recurrent chronic myelogenous leukemia. In these patients complete molecular remissions were induced that persist without further maintenance treatment. These results have been confirmed in larger multicenter studies in Europe and the USA. The best results were obtained in chronic myelogenous leukemia (CML); repeated successes have been reported in relapsing acute myeloid leukemia (AML), myelodysplastic syndromes and multiple myeloma (MMY), and rare responses were reported for acute lymphoid leukemia. Contrary to animal experiments GVHD has been observed in human patients although to a lesser extent than expected in transplants not given immunosuppression. Secondly myelosuppression has been observed in patients treated with relapsing CML. In CML the incidence of GVHD could be reduced by depleting CD8+ T cells from the donor lymphocyte concentrate. Alternatively only small numbers of T lymphocytes can be transfused and in the case of failing responses, the numbers of donor lymphocytes may be increased. Results in recurrent AML have been improved by the use of low-dose cytosine arabinoside, granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor mobilized blood cells as compared to lymphocytes only. In MMY the response rate is higher than in AML, but the remissions are of limited duration in most patients. Several protocols have been designed to include preemptive donor lymphocyte transfusion in patients with a high relapse risk after transplantation. Problems remain to avoid chronic GVHD and to circumvent the immune escape mechanisms of leukemia.
Effect of expandable graphite particle size on the flame retardant, mechanical, and thermal properties of water‐blown semi‐rigid polyurethane foam

Different particle size of expandable graphite (EG) were incorporated into water-blown semi-rigid polyurethane foams (SPFs), which acted as the fire shield, in order to enhance the fire retardant properties. In this study, the particle size of EG was systematically varied from 70 µm to 960 µm. The effect of EG particle size on the density, mechanical properties, and thermal stability of SPFs was also investigated. Results showed that EG with smaller particle size showed almost no effect on the fire retardant properties of SPFs while the larger particle size of EG could effectively enhance it. It was observed that the flame retardancy of the composite improved with the increase of EG size which was attribute to the formation and densification of isolation layer with the increase in volume of expanded graphite. Limiting oxygen index (LOI) value of EG/SPF composites increased linearly by two steps with the increase in EG particle size. Horizontal burning test confirmed the above conclusion. Thermogravimetric analysis (TGA) indicated that EG particles and its size exhibited minor effect on the thermal stability of the SPF composites. Moreover, SPF filled with medium particle size of EG (about 400 µm) exhibited a poor compression performance compared with the others. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 39885.
Effects of Peripapillary Scleral Stiffening on the Deformation of the Lamina Cribrosa

Purpose Scleral stiffening has been proposed as a treatment for glaucoma to protect the lamina cribrosa (LC) from excessive intraocular pressure–induced deformation. Here we experimentally evaluated the effects of moderate stiffening of the peripapillary sclera on the deformation of the LC. Methods An annular sponge, saturated with 1.25% glutaraldehyde, was applied to the external surface of the peripapillary sclera for 5 minutes to stiffen the sclera. Tissue deformation was quantified in two groups of porcine eyes, using digital image correlation (DIC) or computed tomography imaging and digital volume correlation (DVC). In group A (n = 14), eyes were subjected to inflation testing before and after scleral stiffening. Digital image correlation was used to measure scleral deformation and quantify the magnitude of scleral stiffening. In group B (n = 5), the optic nerve head region was imaged using synchrotron radiation phase-contrast microcomputed tomography (PC μCT) at an isotropic spatial resolution of 3.2 μm. Digital volume correlation was used to compute the full-field three-dimensional deformation within the LC and evaluate the effects of peripapillary scleral cross-linking on LC biomechanics. Results On average, scleral treatment with glutaraldehyde caused a 34 ± 14% stiffening of the peripapillary sclera measured at 17 mm Hg and a 47 ± 12% decrease in the maximum tensile strain in the LC measured at 15 mm Hg. The reduction in LC strains was not due to cross-linking of the LC. Conclusions Peripapillary scleral stiffening is effective at reducing the magnitude of biomechanical strains within the LC. Its potential and future utilization in glaucoma axonal neuroprotection requires further investigation.
Immune consequences of penfluridol treatment associated with inhibition of glioblastoma tumor growth

Glioblastoma is the most common and lethal brain tumor associated with only 12% median survival rate of patients. Despite the development of advanced surgical, radiation or use of combinations of anti-cancer drugs, treatment for glioblastoma patients is still a challenge. The major contributing factor in glioblastoma progression and resistive nature is its ability to evade the immune surveillance. Hence, modulating the immune system in glioblastoma tumors could be an important strategy for anticancer therapeutics. Penfluridol, an antipsychotic drug has been shown to have anti-cancer properties in our recently published studies. The present study evaluates the immune response of penfluridol in glioblastoma tumors. Our results demonstrated that penfluridol treatment significantly suppressed glioblastoma tumor growth. Our current results demonstrated about 72% suppression of myeloid derived suppressor cells (MDSCs) with penfluridol treatment in mouse bearing U87MG glioblastoma tumors. MDSCs are known to increase regulatory T cells (Treg), which are immunosuppressive in nature and suppresses M1 macrophages that are tumor suppressive in nature. Our results also showed suppression of regulatory T cells as well as elevation of M1 macrophages with penfluridol treatment by 58% and 57% respectively. Decrease in CCL4 as well as IFNγ with penfluridol treatment was also observed indicating decrease in overall tumor inflammation. This is the first report demonstrating immune modulations by penfluridol treatment associated with glioblastoma tumor growth suppression prompting further investigation to establish penfluridol as a treatment option for glioblastoma patients.