Miracle-dz/UniFAR-FTUs huggingface dataset:
Cognitive Impairment in Pain through Amygdala-Driven Prefrontal Cortical Deactivation

Cognitive deficits such as impaired decision-making can be a consequence of persistent pain. Normal functions of the intact amygdala and prefrontal cortex are required for emotion-based decision-making that relies on the ability to assess risk, attribute value, and identify advantageous strategies. We tested the hypothesis that pain-related cognitive deficits result from amygdala-driven impairment of medial prefrontal cortical (mPFC) function. To do this, we used electrophysiological single-unit recordings in vivo, patch clamp in brain slices, and various behavioral assays to show that increased neuronal activity in the amygdala in an animal model of arthritis pain was accompanied by decreased mPFC activation and impaired decision-making. Furthermore, pharmacologic inhibition (with a corticotropin-releasing factor 1 receptor antagonist) of pain-related hyperactivity in the basolateral amygdala (BLA), but not central amygdala (CeA), reversed deactivation of mPFC pyramidal cells and improved decision-making deficits. Pain-related cortical deactivation resulted from a shift of balance between inhibitory and excitatory synaptic transmission. Direct excitatory transmission to mPFC pyramidal cells did not change in the pain model, whereas polysynaptic inhibitory transmission increased. GABAergic transmission was reduced by non-NMDA receptor antagonists, suggesting that synaptic inhibition was glutamate driven. The results are consistent with a model of BLA-driven feedforward inhibition of mPFC neurons. In contrast to the differential effects of BLA versus CeA hyperactivity on cortical-cognitive functions, both amygdala nuclei modulate emotional-affective pain behavior. Thus, this study shows that the amygdala contributes not only to emotional-affective but also cognitive effects of pain. The novel amygdalo-cortical pain mechanism has important implications for our understanding of amygdala functions and amygdalo-cortical interactions.
Reference-Day Risk and the Use of Monthly Returns Data

Investment practitioners and the empirical finance literature make extensive use of monthly stock returns, where a monthly return is based on the change in stock price between one particular day of the calendar month—the reference day—and the corresponding day of the following month. We show that the choice of reference day seriously affects estimates of the properties of monthly returns, including their means, medians, variances, correlations, and betas. We find these effects both in individual stocks and in market indexes. Our evidence indicates the effects are generally unsystematic and are caused by sampling variation but are sufficiently pervasive and serious to suggest that studies that use estimates of the properties of monthly returns as inputs, and portfolio decisions based on such estimates, should be tested for robustness against different reference days.
First-time mothers: social support, maternal parental self-efficacy and postnatal depression.

AIMS AND OBJECTIVES To examine the relationships between social support, maternal parental self-efficacy and postnatal depression in first-time mothers at 6 weeks post delivery. BACKGROUND Social support conceptualised and measured in different ways has been found to positively influence the mothering experience as has maternal parental self-efficacy. No research exists which has measured the relationships between social support, underpinned by social exchange theory and maternal parental self-efficacy using a domain-specific instrument, underpinned by self-efficacy theory and postnatal depression, with first-time mothers at 6 weeks post delivery. DESIGN A quantitative correlational descriptive design was used. METHOD Data were collected using a five-part questionnaire package containing a researcher developed social support questionnaire, the Perceived Maternal Parental Self-Efficacy Scale and the Edinburgh Postnatal Depression Scale. Four hundred and ten mothers completed questionnaires at 6 weeks post delivery. RESULTS Significant relationships were found between functional social support and postnatal depression; informal social support and postnatal depression; maternal parental self-efficacy and postnatal depression and informal social support and maternal parental self-efficacy at 6 weeks post delivery. CONCLUSION Nurses and midwives need to be aware of and acknowledge the significant contribution of social support, particularly from family and friends in positively influencing first-time mothers' mental health and well-being in the postpartum period. The development of health care policy and clinical guidelines needs to define and operationalise social support to enhance maternal parental self-efficacy. RELEVANCE TO CLINICAL PRACTICE These findings suggest that nurses and midwives need to be cognisant of the importance of social support for first-time mothers in both enhancing maternal parental self-efficacy and reducing postnatal depressive symptomatology in the early postpartum period.
When supercolonies collide: territorial aggression in an invasive and unicolonial social insect

Some species of ants possess an unusual form of social organization in which aggression among nests is absent. This type of social organization, called unicoloniality, has been studied in only a handful of species and its evolutionary origins remain unclear. To date, no study has examined behavioural and genetic patterns at points of contact between the massive supercolonies that characterize unicoloniality. Since interactions at territory boundaries influence the costs of aggression and the likelihood of gene flow, such data may illuminate how supercolonies are formed and maintained. Here we provide field data on intraspecific territoriality for a widespread and invasive unicolonial social insect, the Argentine ant (Linepithema humile). We observed abrupt and well‐defined behavioural boundaries at 16 contact zones between three different pairs of supercolonies. We visited nine of these zones weekly during a six‐month period and observed consistent and intense intercolony aggression that resulted in variable, but often large, levels of worker mortality. Microsatellite variation along six transects across territory borders showed that FST values were lower within supercolonies (0.08 ± 0.01 (mean ± SE)) than between supercolonies (0.29 ± 0.01) and that this disparity was especially strong right at territory borders, despite direct and prolonged contact between the supercolonies. Matrix correspondence tests confirmed that levels of aggression and genetic differentiation were significantly correlated, but no relationship existed between geographic distance and either intraspecific aggression or genetic differentiation. Patterns of FST variation indicated high levels of gene flow within supercolonies, but little to no gene flow between them. Overall, these findings are inconsistent with a model of relaxed ecological constraints leading to colony fusion and suggest that environmentally derived cues are not the prime determined of nestmate recognition in field populations of Argentine ants.
Colors, colored overlays, and reading skills

In this article, we are concerned with the role of colors in reading written texts. It has been argued that colored overlays applied above written texts positively influence both reading fluency and reading speed. These effects would be particularly evident for those individuals affected by the so called Meares-Irlen syndrome, i.e., who experience eyestrain and/or visual distortions – e.g., color, shape, or movement illusions – while reading. This condition would interest the 12–14% of the general population and up to the 46% of the dyslexic population. Thus, colored overlays have been largely employed as a remedy for some aspects of the difficulties in reading experienced by dyslexic individuals, as fluency and speed. Despite the wide use of colored overlays, how they exert their effects has not been made clear yet. Also, according to some researchers, the results supporting the efficacy of colored overlays as a tool for helping readers are at least controversial. Furthermore, the very nature of the Meares-Irlen syndrome has been questioned. Here we provide a concise, critical review of the literature.
A Quantitative Study of the Mechanisms behind Thymic Atrophy in Gαi2-Deficient Mice during Colitis Development

Mice deficient for the G protein subunit Gαi2 spontaneously develop colitis, a chronic inflammatory disease associated with dysregulated T cell responses. We and others have previously demonstrated a thymic involution in these mice and an aberrant thymocyte dynamics. The Gαi2−/− mice have a dramatically reduced fraction of double positive thymocytes and an increased fraction of single positive (SP) thymocytes. In this study, we quantify a number of critical parameters in order to narrow down the underlying mechanisms that cause the dynamical changes of the thymocyte development in the Gαi2−/− mice. Our data suggest that the increased fraction of SP thymocytes results only from a decreased number of DP thymocytes, since the number of SP thymocytes in the Gαi2−/− mice is comparable to the control littermates. By measuring the frequency of T cell receptor excision circles (TRECs) in the thymocytes, we demonstrate that the number of cell divisions the Gαi2−/− SP thymocytes undergo is comparable to SP thymocytes from control littermates. In addition, our data show that the mature SP CD4+ and CD8+ thymocytes divide to the same extent before they egress from the thymus. By estimating the number of peripheral TREC+ T lymphocytes and their death rate, we could calculate the daily egression of thymocytes. Gαi2−/− mice with no/mild and moderate colitis were found to have a slower export rate in comparison to the control littermates. The quantitative measurements in this study suggest a number of dynamical changes in the thymocyte development during the progression of colitis.
HIV and cancer registry linkage identifies a substantial burden of cancers in persons with HIV in India

Abstract We utilized computerized record-linkage methods to link HIV and cancer databases with limited unique identifiers in Pune, India, to determine feasibility of linkage and obtain preliminary estimates of cancer risk in persons living with HIV (PLHIV) as compared with the general population. Records of 32,575 PLHIV were linked to 31,754 Pune Cancer Registry records (1996–2008) using a probabilistic-matching algorithm. Cancer risk was estimated by calculating standardized incidence ratios (SIRs) in the early (4–27 months after HIV registration), late (28–60 months), and overall (4–60 months) incidence periods. Cancers diagnosed prior to or within 3 months of HIV registration were considered prevalent. Of 613 linked cancers to PLHIV, 188 were prevalent, 106 early incident, and 319 late incident. Incident cancers comprised 11.5% AIDS-defining cancers (ADCs), including cervical cancer and non-Hodgkin lymphoma (NHL), but not Kaposi sarcoma (KS), and 88.5% non-AIDS-defining cancers (NADCs). Risk for any incident cancer diagnosis in early, late, and combined periods was significantly elevated among PLHIV (SIRs: 5.6 [95% CI 4.6–6.8], 17.7 [95% CI 15.8–19.8], and 11.5 [95% CI 10–12.6], respectively). Cervical cancer risk was elevated in both incidence periods (SIRs: 9.6 [95% CI 4.8–17.2] and 22.6 [95% CI 14.3–33.9], respectively), while NHL risk was elevated only in the late incidence period (SIR: 18.0 [95% CI 9.8–30.20]). Risks for NADCs were dramatically elevated (SIR > 100) for eye-orbit, substantially (SIR > 20) for all-mouth, esophagus, breast, unspecified-leukemia, colon-rectum-anus, and other/unspecified cancers; moderately elevated (SIR > 10) for salivary gland, penis, nasopharynx, and brain-nervous system, and mildly elevated (SIR > 5) for stomach. Risks for 6 NADCs (small intestine, testis, lymphocytic leukemia, prostate, ovary, and melanoma) were not elevated and 5 cancers, including multiple myeloma not seen. Our study demonstrates the feasibility of using probabilistic record-linkage to study cancer/other comorbidities among PLHIV in India and provides preliminary population-based estimates of cancer risks in PLHIV in India. Our results, suggesting a potentially substantial burden and slightly different spectrum of cancers among PLHIV in India, support efforts to conduct multicenter linkage studies to obtain precise estimates and to monitor cancer risk in PLHIV in India.
Estimating the Effect of Common Currencies on Trade: The Case Study of EU and Turkey

Here is estimated the effect of monetary union and the exchange rate volatility on trade. First of all, Frankel and Rose (1997, 1998) have developed the idea that the suitability of European countries for the EMU cannot be judged on the basis of historical data. I use an augmented gravity model to estimate the effects of currency unions and exchange rate volatility on trade. The model is “augmented” in that the standard gravity model only includes income and distance variables. The estimated results show that two countries that use the same currency trade more, but it can be seen that the currency union effect of trade is not large. These findings are similar to those in Nardis and Vicarelli (2003). That is, they are not as large as those found in Rose (2000) and Glick and Rose (2002). The effect of the variable of ECU is also positive und significant. These findings are similar to those in Berger and Nitsch (2005), which claim that the potential trade-creating affects of the EMU must be viewed and analyzed in the proper historical perspective.
Survey error in measuring socio-economic risk factors of health status: a comparison of a survey and a census.

BACKGROUND Individuals of lower socio-economic status (SES) are less likely to participate in health surveys than individuals of a higher SES. It is, however, not known whether this difference in participation is associated with health status. This study sets out to assess whether a population health survey gives biased estimates of socio-economic inequalities in self-reported health. METHODS We compared two independent cross-national data collections, a national health interview survey (n = 10,164) and a census (n = 8,491,528), both carried out in Belgium in 2001 and posing the same health question. We computed the prevalence ratios of poor subjective health among socio-economic groups. To estimate the bias, a relative odds ratio (ROR) was computed as the ratio of the survey prevalence ratio to the census prevalence ratio. RESULTS Less-educated individuals had a lower risk of poor health status in the survey [Prevalence ratio = 1.66, 95% confidence interval (CI): 1.48-1.86] than in the census (Prevalence ratio = 2.23) leading to an underestimation of the risk associated with low education (ROR = 0.74, 95% CI 0.66-0.83). Compared with better-off groups, those who were not working or who were less educated were generally less likely to participate in the survey when they had a poor health status. CONCLUSIONS Overall, the health survey underestimated the effects of low SES on poor health status, due to selection bias. We conclude that strategies to improve participation among disadvantaged socio-economic groups should be identified.
Financial Instability and Optimal Monetary Policy Rule

This paper investigates the effect of financial instability on the design of monetary policy rule for a small open economy. We find evidence that optimal monetary policy rule reacts directly to financial imbalances and, as a result, to the real exchange rate movements. However, optimal rule would not react to the real exchange rate changes directly if central bank does not care about the financial instability. For a quantitative analysis, impulse responses of some macroeconomic variables and financial instability to the domestic productivity and foreign country output shocks, resulting from simulation, are also analysed in this paper.
An Enhanced H/ACA RNP Assembly Mechanism for Human Telomerase RNA

ABSTRACT The integral telomerase RNA subunit templates the synthesis of telomeric repeats. The biological accumulation of human telomerase RNA (hTR) requires hTR H/ACA domain assembly with the same proteins that assemble on other human H/ACA RNAs. Despite this shared RNP composition, hTR accumulation is particularly sensitized to disruption by disease-linked H/ACA protein variants. We show that contrary to expectation, hTR-specific sequence requirements for biological accumulation do not act at an hTR-specific step of H/ACA RNP biogenesis; instead, they enhance hTR binding to the shared, chaperone-bound scaffold of H/ACA core proteins that mediates initial RNP assembly. We recapitulate physiological H/ACA RNP assembly with a preassembled NAF1/dyskerin/NOP10/NHP2 scaffold purified from cell extract and demonstrate that distributed sequence features of the hTR 3′ hairpin synergize to improve scaffold binding. Our findings reveal that the hTR H/ACA domain is distinguished from other human H/ACA RNAs not by a distinct set of RNA-protein interactions but by an increased efficiency of RNP assembly. Our findings suggest a unifying mechanism for human telomerase deficiencies associated with H/ACA protein variants.
Working Memory and Its Relation to Deterministic Sequence Learning

Is there a relation between working memory (WM) and incidental sequence learning? Nearly all of the earlier investigations in the role of WM capacity (WMC) in sequence learning suggest no correlations in incidental learning conditions. However, the theoretical view of WM and operationalization of WMC made strong progress in recent years. The current study related performance in a coordination and transformation task to sequence knowledge in a four-choice incidental deterministic serial reaction time (SRT) task and a subsequent free generation task. The response-to-stimulus interval (RSI) was varied between 0 ms and 300 ms. Our results show correlations between WMC and error rates in condition RSI 0 ms. For condition RSI 300 ms we found relations between WMC and sequence knowledge in the SRT task as well as between WMC and generation task performance. Theoretical implications of these findings for ongoing processes during sequence learning and retrieval of sequence knowledge are discussed.
Facilitating information and communication technology (ICT) adoption among research scientists in Ghana

(This chapter is modified version of an article published in the e-journal Library Philosophy and Practice in 2012. Editors are thankful to the Journal for providing necessary permissions to include this article in this book.) Abstract. This study examines the impact of Information and Communication Technology (ICT) on information provision for research officers in six selected institutes of the Council for Scientific and Industrial Research (CSIR), Ghana. It seeks to determine the levels of awareness, access to, and use of ICT facilities and services of research officers; the extent to which research officers are given training in the use of ICT and levels of skills acquired; and the effects of ICT use on the research activities of research officers. Questionnaires and interviews are used in the data collection. Questionnaires were administered to 100 respondents. The respondents include the Directors and the Librarians who were interviewed as well. The study reveals that the levels of awareness, access to, and use of computers, the Internet, and databases by research officers are high. The study also shows that generally, the level of skills acquired in the use of ICT was high. The research also reveals that the use of ICT enhanced work performance of the research officers. The basic conclusion of this study is that the use of ICT infrastructure has impacted positively on information provision for research officers in the six selected institutes of CSIR. The study recommends the need for librarians in CSIR to effectively publicize the ICT facilities and services available in their institutes in order to increase awareness and patronage. The study also recommends the need for adequate and continuous training for the research officers in the use of ICT facilities and services.
Population dynamics and potential of fisheries stock enhancement: practical theory for assessment and policy analysis

The population dynamics of fisheries stock enhancement, and its potential for generating benefits over and above those obtainable from optimal exploitation of wild stocks alone are poorly understood and highly controversial. I review pertinent knowledge of fish population biology, and extend the dynamic pool theory of fishing to stock enhancement by unpacking recruitment, incorporating regulation in the recruited stock, and accounting for biological differences between wild and hatchery fish. I then analyse the dynamics of stock enhancement and its potential role in fisheries management, using the candidate stock of North Sea sole as an example and considering economic as well as biological criteria. Enhancement through release of recruits or advanced juveniles is predicted to increase total yield and stock abundance, but reduce abundance of the naturally recruited stock component through compensatory responses or overfishing. Economic feasibility of enhancement is subject to strong constraints, including trade–offs between the costs of fishing and hatchery releases. Costs of hatchery fish strongly influence optimal policy, which may range from no enhancement at high cost to high levels of stocking and fishing effort at low cost. Release of genetically maladapted fish reduces the effectiveness of enhancement, and is most detrimental overall if fitness of hatchery fish is only moderately compromised. As a temporary measure for the rebuilding of depleted stocks, enhancement cannot substitute for effort limitation, and is advantageous as an auxiliary measure only if the population has been reduced to a very low proportion of its unexploited biomass. Quantitative analysis of population dynamics is central to the responsible use of stock enhancement in fisheries management, and the necessary tools are available.
Biosimilars 101: considerations for U.S. oncologists in clinical practice

Biosimilars of biologics used for cancer treatment and supportive care are expected to enter the U.S. market soon. Biosimilars will be highly similar to their reference products, but unlike generic drugs, not identical. Differences between a biosimilar and its reference product may arise because of the complexity of biologics, and differences in the cell lines and processes used during manufacturing. Biosimilars will be approved in the United States through a regulatory pathway based on comparative analytical and clinical studies for their characterization and demonstration of no clinically meaningful differences from their reference products. Unlike generics, initial approval may not include interchangeability, as additional evidence may be required before a biosimilar could be approved as interchangeable with its reference product; interchangeable designation could allow pharmacy‐level substitution without prescriber intervention. In some cases, the U.S. Food and Drug Administration (FDA) may extrapolate an indication that has not been formally investigated for the biosimilar but that is approved for the reference product. Robust safety monitoring of all biologics is important to track and accurately attribute adverse events, particularly because their inherent complexity and manufacturing differences make them susceptible to structural changes that can affect safety (e.g., immunogenicity). Accuracy of postapproval safety reports will partly depend on the biosimilar naming approach. Potential cost savings should be evaluated in the context of differences in manufacturers' patient‐assistance programs, copayments, and institutional costs. A manufacturer's ability to ensure reliable supply of high‐quality biosimilars should also be considered. Broad understanding of these issues is critical for oncologists preparing for their use in clinical practice.