Miracle-dz/UniFAR-FTUs huggingface dataset:
A Coastal Seawater Temperature Dataset for Biogeographical Studies: Large Biases between In Situ and Remotely-Sensed Data Sets around the Coast of South Africa

Gridded SST products developed particularly for offshore regions are increasingly being applied close to the coast for biogeographical applications. The purpose of this paper is to demonstrate the dangers of doing so through a comparison of reprocessed MODIS Terra and Pathfinder v5.2 SSTs, both at 4 km resolution, with instrumental in situ temperatures taken within 400 m from the coast. We report large biases of up to +6°C in places between satellite-derived and in situ climatological temperatures for 87 sites spanning the entire ca. 2 700 km of the South African coastline. Although biases are predominantly warm (i.e. the satellite SSTs being higher), smaller or even cold biases also appear in places, especially along the southern and western coasts of the country. We also demonstrate the presence of gradients in temperature biases along shore-normal transects — generally SSTs extracted close to the shore demonstrate a smaller bias with respect to the in situ temperatures. Contributing towards the magnitude of the biases are factors such as SST data source, proximity to the shore, the presence/absence of upwelling cells or coastal embayments. Despite the generally large biases, from a biogeographical perspective, species distribution retains a correlative relationship with underlying spatial patterns in SST, but in order to arrive at a causal understanding of the determinants of biogeographical patterns we suggest that in shallow, inshore marine habitats, temperature is best measured directly.
Sensitive to 1-Topoisomerase Inhibitors , or Staurosporine but Remains Enhanced Survival on Exposure to Serum Deprivation , An MCL 1-overexpressing Burkitt Lymphoma Subline Exhibits

Members of the BCL2 gene family influence cell viability and can, therefore, affect the susceptibility of cancer cells to multiple chemotherapeutic agents. Thus, it is a challenge to devise approaches for inducing the death of tumor cells in which the expression of prosurvival family members is elevated or deregulated. BL41-3, a spontaneously derived subline of BL41 Burkitt lymphoma cells, was found to have amplified the prosurvival MCL1 gene (3-fold) and overexpressed the MCL1 protein. The level of MCL1 protein was 5-fold elevated compared with ML-1 cells expressing maximal MCL1 on exposure to phorbol-12-myristate-13acetate. To assess whether this increase in MCL1 expression was associated with enhanced protection from cell death, cells were exposed to conditions of growth factor deprivation or to various cytotoxic agents. Whereas BL41-3 and BL41 cells exhibited similar growth rates in logarithmic phase, BL41-3 cells remained largely viable on reaching saturation phase in contrast to BL41 cells, which began to die. Similarly, the BL41-3 subline remained viable for an extended period under conditions of reduced serum. BL41-3 cells were also more resistant to the apoptosisinducing effects of etoposide, camptothecin, and staurosporine (>3-fold more than BL41 cells). Unexpectedly, these cells exhibited enhanced sensitivity to 1-D-arabinofuranosylcytosine, but only on exposure for an extended period (>10-fold more sensitive than BL41 cells with a 24-h but not a 6-h exposure). Thus, whereas cells expressing prosurvival BCL2 family members are frequently resistant to a variety of chemotherapeutic agents, the findings presented here, using a cell line exhibiting amplification and overexpression of MCL1, indicate that such cells may exhibit increased sensitivity to certain chemotherapeutic regimens.
Relative frequency, Possible Risk Factors, Viral Codetection Rates, and Seasonality of Respiratory Syncytial Virus Among Children With Lower Respiratory Tract Infection in Northeastern Brazil

AbstractFew studies, each limited to a single major city, have investigated the prevalence and seasonal patterns of different viruses among children with low respiratory tract infections (LRTI) in Northeastern Brazil. The aim of this study was to determine the frequency of respiratory syncytial virus (RSV) and of 7 other viruses in children for LRTI in 4 capitals from this region, and investigate their association with several risk factors, including meteorological data.From April 2012 to March 2013, 507 children, aged up to 24 months and hospitalized with LRTI in one of the participating centers at Aracajú, Salvador, Recife, and Maceió, had a sample of nasopharyngeal aspirate collected and analyzed for the following viruses by reverse-transcription polymerase chain reaction followed by hybridization on low-density microarrays: RSV, influenza, parainfluenza, adenovirus, rhinovirus, metapneumovirus, bocavirus, and coronavirus.The result was positive in 66.5% of cases, RSV was the most common virus (40.2%). Except for rhinovirus (17%), all other virus had frequency rates lower than 6%. Viral coinfections were detected in 13.8% of samples. Possible related risk factors for RSV infection were low age upon entry, attendance of daycare, low gestational age, and low educational level of the father. The relative frequency of viral infections was associated with increasing temperature and decreasing humidity separately, but the results also suggested both associated with increased frequency of RSV. Some of these findings differ from those reported for other regions in Brazil and may be used to guide policies that address LRTI.
The Toxic Effects of Polychemotherapy onto the Liver Are Accelerated by the Upregulated MDR of Lymphosarcoma

Antitumor therapy of hematological malignancies is impeded due to the high toxicity of polychemotherapy toward liver and increasing multiple drug resistance (MDR) of tumor cells under the pressure of polychemotherapy. These two problems can augment each other and significantly reduce the efficiency of antineoplastic therapy. We studied the combined effect of polychemotherapy and upregulated MDR of lymphosarcoma RLS40 onto the liver of experimental mice using two treatment schemes. Scheme 1 is artificial: the tumor was subjected to four courses of polychemotherapy while the liver of the tumor-bearing mice was exposed to only one. This was achieved by threefold tumor retransplantation taken from animals subjected to chemotherapy into intact animals. Scheme 2 displays “real-life” status of patients with MDR malignancies: both the tumor and the liver of tumor-bearing mice were subjected to three sequential courses of polychemotherapy. Our data show that the strengthening of MDR phenotype of RLS40 under polychemotherapy and toxic pressure of polychemotherapy itself has a synergistic damaging effect on the liver that is expressed in the accumulation of destructive changes in the liver tissue, the reduction of the regeneration capacity of the liver, and increasing of Pgp expression on the surface of hepatocytes.
Department of Economics Econometrics Working Paper Ewp0505 Benford's Law and Naturally Occurring Prices in Certain Ebay Auctions*

We show that certain the winning bids for certain ebaY auctions obey Benford's Law. One implication of this is that it is unlikely that these bids are subject to collusion among bidders, or " shilling " on the part of sellers. Parenthetically, we also show that numbers from the naturally occurring Fibonacci and Lucas sequences also obey Benford's Law. 1. Introduction Consider the daily return on a stock on the NYSE. What is the probability that the first significant digit in the return is a " 1 " , or a " 9 " , for example? Contrary to what one might think, the answer is not (1/9) in either case. Newcomb (1881) appears to have been the first to notice that many naturally occurring decimal numbers have a first significant digit that is " 1 " with probability approximately 31%, while the probability of this digit being " 9 " is less than 5%. His examination of this phenomenon was motivated by observing that the first few pages of books of logarithm tables were generally dirtier (as a result of being thumbed more often) than were later pages. His results were not widely appreciated, and were unwittingly " rediscovered " by Benford (1938). Benford provided numerous examples of data that obey a particular non-uniform distribution with respect to first significant digits, and the phenomenon became known as " Benford's Law ". His examples included the areas of lakes, the lengths of rivers, and the molecular weights of have confirmed that Benford's Law holds for a very large range of phenomena, including certain economic data. The purpose of this note is to examine whether Benford's Law holds in the context of certain ebaY auction prices. The importance of the results that we obtain is that they can be used as a test of collusion in that market place In the next section we discuss Benford's Law and illustrate its application to two important naturally occurring data-sets. The main results of the paper are given in section 3, where we consider an analysis of ebaY auction prices; and section 4 concludes. Let d denote the first significant digit in a random decimal number, N. So, for example, if N = 194.23 then d = 1; and if N = 0.00476 then d = 4. Benford's Law dictates that)] / 1 (1 [ log ] . [ Pr 10 k k d + …
A novel infrastructure WLAN locating method based on neural network

Comparing to the client based locating, infrastructure based methods do not require install special software or hardware at client side. So it not only fits for real deployment, but also supports some specific requirement (ex target tracking). Former researchers mainly adopt k-NN method in infrastructure based locating. However, its computing complexity is proportional to the size of sample set, which makes it unscalable when the system grows large. This paper proposes a novel infrastructure WLAN locating method by utilizing neural networks and a new training method to overcome the effect of different power levels of client devices. Through real deployment and testing, the result shows that the computing complexity is much lower than the k-NN method, while the accuracy is very close.
Differential Associations of Depressive Symptom Dimensions with Cardio-Vascular Disease in the Community: Results from the Gutenberg Health Study

A current model suggested that the somatic symptom dimension accounts for the adverse effect of depression in patients with coronary heart disease (CHD). In order to test this model we sought to determine in a large population-based sample how symptom dimensions of depression are associated with CHD, biomarkers and traditional risk factors. The associations of cognitive and somatic symptom dimensions of depression with CHD, risk factors, endothelial function, and biomarkers of inflammation and myocardial stress were analyzed cross-sectionally in a sample of n = 5000 Mid-Europeans aged 35–74 years from the Gutenberg Health Study (GHS). Only the somatic symptom dimension of depression was associated with CHD, biomarkers (inflammation, vascular function) and cardio-vascular risk factors. When multivariable adjustment was applied by demographic and cardiovascular risk factors, the weak associations of the somatic symptom dimension with the biomarkers disappeared. However, the associations of the somatic symptom dimension with CHD, myocardial infarction, obesity, dyslipidemia and family history of myocardial infarction remained. Both dimensions of depression were independently associated with a previous diagnosis of depression and distressed personality (type D). Thus, our results partly confirm current models: Somatic, but not cognitive-affective symptom dimensions are responsible for the association between depression and CHD, inflammation, vascular function and cardiovascular risk factors in the general population. However, our findings challenge the assumptions that somatic depression might be due to inflammation or vascular dysfunction as consequence of progressed atherosclerotic disease. They rather emphasize a close interplay with life-style factors and with a family history of MI.
Using Templates to Predict Execution Time of Scientific Workflow Applications in the Grid

Workflow execution time predictions for Grid infrastructures is of critical importance for optimized workflow executions, advance reservations of resources, and overhead analysis. Predicting workflow execution time is complex due to multeity of workflow structures, involvement of several Grid resources in workflow execution, complex dependencies of workflow activities and dynamic behavior of the Grid. In this paper we present an online workflow execution time prediction system exploiting similarity templates. The workflows are characterized considering the attributes describing their performance at different Grid infrastructural levels. A “supervised exhaustive search” is employed to find suitable templates. We also make a provision of including expert user knowledge about the workflow performance in the procession of our methods. Results for three real world applications are presented to show the effectiveness of our approach.
Substrate-Dependent Inhibition of the Human Organic Cation Transporter OCT2: A Comparison of Metformin with Experimental Substrates

The importance of the organic cation transporter OCT2 in the renal excretion of cationic drugs raises the possibility of drug-drug interactions (DDIs) in which an inhibitor (perpetrator) drug decreases OCT2-dependent renal clearance of a victim (substrate) drug. In fact, there are clinically significant interactions for drugs that are known substrates of OCT2 such as metformin. To identify drugs as inhibitors for OCT2, individual drugs or entire drug libraries have been investigated in vitro by using experimental probe substrates such as 1-methyl-4-phenylpyridinium (MPP+) or 4–4-dimethylaminostyryl-N-methylpyridinium (ASP+). It has been questioned whether the inhibition data obtained with an experimental probe substrate such as MPP+ or ASP+ might be used to predict the inhibition against other, clinical relevant substrates such as metformin. Here we compared the OCT2 inhibition profile data for the substrates metformin, MPP+ and ASP+. We used human embryonic kidney (HEK 293) cells stably overexpressing human OCT2 as the test system to screen 125 frequently prescribed drugs as inhibitors of OCT2-mediated metformin and MPP+ uptake. Data on inhibition of OCT2-mediated ASP+ uptake were obtained from previous literature. A moderate correlation between the inhibition of OCT2-mediated MPP+, ASP+, and metformin uptake was observed (pairwise r s between 0.27 and 0.48, all P < 0.05). Of note, the correlation in the inhibition profile between structurally similar substrates such as MPP+ and ASP+ (Tanimoto similarity T = 0.28) was even lower (r s = 0.27) than the correlation between structurally distinct substrates, such as ASP+ and metformin (T = 0.01; r s = 0.48) or MPP+ and metformin (T = 0.01; r s = 0.40). We identified selective as well as universal OCT2 inhibitors, which inhibited transport by more than 50% of one substrate only or of all substrates, respectively. Our data suggest that the predictive value for drug-drug interactions using experimental substrates rather than the specific victim drug is limited.
LARP7 is a stable component of the 7SK snRNP while P-TEFb, HEXIM1 and hnRNP A1 are reversibly associated

Regulation of the elongation phase of RNA polymerase II transcription by P-TEFb is a critical control point for gene expression. The activity of P-TEFb is regulated, in part, by reversible association with one of two HEXIMs and the 7SK snRNP. A recent proteomics survey revealed that P-TEFb and the HEXIMs are tightly connected to two previously-uncharacterized proteins, the methyphosphate capping enzyme, MEPCE, and a La-related protein, LARP7. Glycerol gradient sedimentation analysis of lysates from cells treated with P-TEFb inhibitors, suggested that the 7SK snRNP reorganized such that LARP7 and 7SK remained associated after P-TEFb and HEXIM1 were released. Immunodepletion of LARP7 also depleted most of the 7SK regardless of the presence of P-TEFb, HEXIM or hnRNP A1 in the complex. Small interfering RNA knockdown of LARP7 in human cells decreased the steady-state level of 7SK, led to an initial increase in free P-TEFb and increased Tat transactivation of the HIV-1 LTR. Knockdown of LARP7 or 7SK ultimately caused a decrease in total P-TEFb protein levels. Our studies have identified LARP7 as a 7SK-binding protein and suggest that free P-TEFb levels are determined by a balance between release from the large form and reduction of total P-TEFb.
Non�?Native Speakers of English in the Classroom: What are the Effects on Pupil Performance?

In recent years there has been an increase in the number of children going to school in England who do not speak English as a first language. We investigate whether this has an impact on the educational outcomes of native English speakers at the end of primary school. We show that the negative correlation observed in the raw data is mainly an artefact of selection: non-native speakers are more likely to attend school with disadvantaged native speakers. We attempt to identify a causal impact of changes in the percentage of non-native speakers within the year group. In general, our results suggest zero effect and rule out negative effects.
An intronic microRNA silences genes that are functionally antagonistic to its host gene

MicroRNAs (miRNAs) are short noncoding RNAs that down-regulate gene expression by silencing specific target mRNAs. While many miRNAs are transcribed from their own genes, nearly half map within introns of ‘host’ genes, the significance of which remains unclear. We report that transcriptional activation of apoptosis-associated tyrosine kinase (AATK), essential for neuronal differentiation, also generates miR-338 from an AATK gene intron that silences a family of mRNAs whose protein products are negative regulators of neuronal differentiation. We conclude that an intronic miRNA, transcribed together with the host gene mRNA, may serve the interest of its host gene by silencing a cohort of genes that are functionally antagonistic to the host gene itself.
Suzaku Observations of the Cluster of Galaxies Abell 2052

The results from Suzaku XIS observations of the relaxed cluster of galaxies Abell2052 are presented. Offset pointing data are used to estimate the Galactic foreground emission in the direction to the cluster. Significant soft X-ray excess emission above this foreground, the intra-cluster medium emission, and other background components is confirmed and resolved spectroscopically and radially. This excess can be described either by (a) local variations of known Galactic emission components or (b) an additional thermal component with temperature of about 0.2 keV, possibly associated with the cluster. The radial temperature and metal abundance profiles of the intra-cluster medium are measured within \sim 20 in radius (about 60% of the virial radius) from the cluster center . The temperature drops radially to 0.5-0.6 of the peak value at a radius of \sim 15'. The gas-mass-weighted metal abundance averaged over the observed region is found to be 0.21 +- 0.05 times solar.
Communicative Behaviors of Sibling Dyads With a Child With Autism

The purpose of this study was to document the communicative behaviors exhibited by sibling dyads comprised of one typically developing child (TDC) and their sibling diagnosed with autism spectrum disorder (SibA). Six families (five families were Caucasian and one family was African American) participated in one 45-minute home observation, one semi-structured interview with the TDCs, and one semi-structured interview with the parents. Sibling dyads varied across birth order, ages, and genders. Observations revealed that the sibling dyads produced a variety of communicative behaviors. Observational data were coded to provide information on the types of communicative behaviors produced and their frequency of occurrence. Data were analyzed to reveal the types of communicative behaviors that both the TDCs and the SibAs produced, as well as the types of communicative behaviors produced only by the TDCs and only by the SibAs. The TDCs provided relevant answers to semi-structured interview questions about their interactions with their SibAs, and the parents provided relevant answers to semi-structured interview questions about their children’s relationships. Four out of the six families provided strong evidence that suggested the possibility of sibling-mediated interventions for children with autism spectrum disorder. Two out of the six families provided some evidence that suggested the possibility of sibling-mediated interventions for children with autism spectrum disorder.
A Mutual Information Characterization for Sparse Signal Processing

Abstract. Suppose among a set of N covariatesX1; X2; . ; XN there is a subsetS of covariates that are salient for predicting outcomes Y . Specifically, we suppose that when Y is conditioned on{Xk}k∈S it is independent of the other covariates. Our goal is to identify the subset S from data samples of the covariates and associated outcomes. We present a precise mutual inform ati n expression that characterizes the sample complexity for accurately id ent fying the subset S
Endotoxin and Cancer

Objective Exposure to endotoxin, a component of gram-negative bacterial cell walls, is widespread in many industrial settings and in the ambient environment. Heavy-exposure environments include livestock farms, cotton textile facilities, and saw mills. Concentrations are highly variable in non-occupational indoor and outdoor environments. Endotoxin is a potent inflammagen with recognized health effects, including fever, shaking chills, septic shock, toxic pneumonitis, and respiratory symptoms. Somewhat paradoxically, given the putative role of inflammation in carcinogenesis, various lines of evidence suggest that endotoxin may prevent cancer initiation or limit tumor growth. The hypothesis that components of bacteria may retard cancer progression dates back to William B. Coley’s therapeutic experiments (“bacterial vaccine”) in the 1890s. Data sources In this article, we review epidemiologic, clinical trial, and experimental studies pertinent to the hypothesis that endotoxin prevents cancer. Since the 1970s, epidemiologic studies of cotton textile and other endotoxin-exposed occupational groups have consistently demonstrated reduced lung cancer risks. Experimental animal toxicology research and some limited therapeutic trials in cancer patients offer additional support for an anticarcinogenic potential. The underlying biological mechanisms of anticarcinogenesis are not entirely understood but are thought to involve the recruitment and activation of immune cells and proinflammatory mediators (e.g., tumor necrosis factor α and interleukin-1 and -6). Conclusions In view of the current state of knowledge, it would be premature to recommend endotoxin as a cancer-chemopreventive agent. Nonetheless, further epidemiologic and experimental investigations that can clarify further dose–effect and exposure–timing relations could have substantial public health and basic biomedical benefits.
Extremes of the discrete two-dimensional Gaussian free field

We consider the lattice version of the free field in two dimensions and study the fractal structure of the sets where the field is unusually high (or low). We then extend some of our computations to the case of the free field conditioned on being everywhere nonnegative. For example, we compute the width of the largest downward spike of a given length. Through the prism of these results, we find that the extrema of the free field under entropic repulsion (minus its mean) and those of the unconditioned free field are identical. Finally, when compared to previous results these findings reveal a suggestive analogy between the square of the free field and the two-dimensional simple random walk on the discrete torus.