Miracle-dz/UniFAR-FTUs huggingface dataset:
Predetermined versus learned linkage models

The linkage tree genetic algorithm (LTGA) learns, each generation, a linkage model by building a hierarchical cluster tree. The LTGA is an instance of the more general gene-pool optimal mixing evolutionary algorithm (GOMEA) that uses a family of subsets (FOS) linkage model. We compare the performance of the linkage model learning LTGA with several predetermined FOS linkage models applied by GOMEA. The predetermined models are matched to the underlying problem structure of four benchmark functions: onemax, deceptive trap functions, maximal overlapping nearest-neighbor NK-landscapes, and weighted MAXCUT problems. Although the a priori fixed models are specifically designed to capture the interactions between the problem variables, experimental results show that - for problems with intricate interaction structure - they are actually less efficient than LTGA that dynamically learns a hierarchical tree model. Some of these observations were unexpected and raise the question of what exactly is the optimal linkage structure for a given problem as used by GOMEA. In the case of the NK-problem a linkage model that is an accurate description of the underlying additively decomposable fitness structure is clearly not an optimal linkage model. Being able to rebuild the linkage model each generation has clear benefits above using fixed, predetermined linkage models.
The efficacy of intrauterine devices for emergency contraception: a systematic review of 35 years of experience.

BACKGROUND Intrauterine devices (IUDs) have been studied for use for emergency contraception for at least 35 years. IUDs are safe and highly effective for emergency contraception and regular contraception, and are extremely cost-effective as an ongoing method. The objective of this study was to evaluate the existing data to estimate the efficacy of IUDs for emergency contraception. METHODS The reference list for this study was generated from hand searching the reference lists of relevant articles and our own article archives, and electronic searches of several databases: Medline, Global Health, Clinicaltrials.gov, Popline, Wanfang Data (Chinese) and Weipu Data (Chinese). We included studies published in English or Chinese, with a defined population of women who presented for emergency contraception and were provided with an IUD, and in which the number of pregnancies was ascertained and loss to follow-up was clearly defined. Data from each article were abstracted independently by two reviewers. RESULTS The 42 studies (of 274 retrieved) that met our inclusion criteria were conducted in six countries between 1979 and 2011 and included eight different types of IUD and 7034 women. The maximum timeframe from intercourse to insertion of the IUD ranged from 2 days to 10 or more days; the majority of insertions (74% of studies) occurred within 5 days of intercourse. The pregnancy rate (excluding one outlier study) was 0.09%. CONCLUSIONS IUDs are a highly effective method of contraception after unprotected intercourse. Because they are safe for the majority of women, highly effective and cost-effective when left in place as ongoing contraception, whenever clinically feasible IUDs should be included in the range of emergency contraception options offered to patients presenting after unprotected intercourse. This review is limited by the fact that the original studies did not provide sufficient data on the delay between intercourse and insertion of the IUD, parity, cycle day of intercourse or IUD type to allow analysis by any of these variables.
Photoplethysmography in the diagnosis of superficial venous valvular incompetence

Photoplethysmography was compared with clinical investigation combined with Doppler ultrasonography in the diagnosis of superficial venous valvular incompetence of the lower limb. In 268 consecutive patients, 536 limbs were investigated. A total of 22.I per cent of the photoplethysmographic investigations were uninterpretable because they did not allow reliable determination of the refilling time. Agreement between clinical investigation combined with Doppler ultrasonography and photoplethysmography was found to be poor (K = 0.30). These results suggest that photoplethysmography is not the non‐invasive method of choice for routine evaluation of superficial venous valvuular incompetence of the leg.
Successful aging: early influences and contemporary characteristics.

PURPOSE positing that successful aging has independent, yet related, dimensions that are both objective and subjective, we examine how early influences and contemporary characteristics define 4 groups of people. DESIGN AND METHODS data were gathered from 5,688 persons aged 50-74 years living in New Jersey who participated in telephone interviews. Latent profile analysis defined people who age successfully according to both objective and subjective criteria, neither criteria, and one, but not the other, criteria. Multinomial logistic regression was used to examine the extent to which early influences and contemporary characteristics predict group membership. RESULTS although characteristics observable early in life predict group membership, their influence is modified by current health behaviors and social support. The roles of education and incarceration feature prominently. Marital, work, and volunteer statuses, as well as moderate alcohol consumption, distinguish those aging successfully according to both criteria from the other 3 groups. IMPLICATIONS results help to define successful aging as a multidimensional construct having both objective and subjective dimensions, provide greater clarity regarding its correlates, and increase understanding of its modifiable aspects.
Influence of particle size and gradation on shear strength–dilation relation of granular materials

Upon close scrutiny of data reported in the literature, taking into account particle-scale characteristics to optimize the precision of the well-known empirical Bolton’s equations and imposing particle-size limits on them is recommended. The present paper examines the potential influence of particle size and grading on the shear strength–dilation relation of granular materials from the results of 276 symmetrical direct shear tests. The applicability of physical symmetrical direct shear tests to interpret the plane strain frictional shearing resistance of granular materials has been widely discussed using the discrete element method (DEM) computer code SiGran. Sixteen different grain-size distribution curves of three different materials were tested at different normal pressures and initial relative densities. It is demonstrated that while the contribution of dilatancy to shear strength is not influenced by the variation in the coefficient of uniformity, Cu, in the investigated range, it significantly decreases with increasing mean particle size, D50. The coefficients of Bolton’s equations have been, therefore, adjusted to account for D50. A comparison of the predictions by the proposed empirical formulas with plane strain friction angle, [Formula: see text], and dilation angle, ψ, data from the literature shows that accounting for the grain size yields more accurate results.
Inhibitory Activities of Colicins against Escherichia coli Strains Responsible for Postweaning Diarrhea and Edema Disease in Swine

ABSTRACT The efficacies of colicins E1 and N against Escherichia coli strains responsible for postweaning diarrhea and edema disease, two of the most prevalent disease problems for pigs in the United States, were determined in vitro. These proteins may provide an environmentally sound means for the prevention of these infections in swine.
An Educational and Physical Program to Reduce Headache, Neck/Shoulder Pain in a Working Community: A Cluster-Randomized Controlled Trial

Background Noninvasive physical management is often prescribed for headache and neck pain. Systematic reviews, however, indicate that the evidence of its efficacy is limited. Our aim was to evaluate the effectiveness of a workplace educational and physical program in reducing headache and neck/shoulder pain. Methodology/Principal Findings Cluster-randomized controlled trial. All municipal workers of the City of Turin, Italy, were invited to participate. Those who agreed were randomly assigned, according to their departments, to the intervention group (IG) or to the control group and were given diaries for the daily recording of pain episodes for 1 month (baseline). Subsequently, only the IG (119 departments, 923 workers) began the physical and educational program, whereas the control group (117 departments, 990 workers) did not receive any intervention. All participants were again given diaries for the daily recording of pain episodes after 6 months of intervention. The primary outcome was the change in the frequency of headache (expressed as the proportion of subjects with a ≥50% reduction of frequency; responder rate); among the secondary outcomes there were the absolute reduction of the number of days per month with headache and neck/shoulder pain. Differences between the two groups were evaluated using mixed-effect regression models. The IG showed a higher responder rate [risk ratio, 95% confidence interval (CI)] for headache (1.58; 1.28 to 1.92) and for neck/shoulder pain (1.53; 1.27 to 1.82), and a larger reduction of the days per month (95% CI) with headache (−1.72; −2.40 to −1.04) and with neck/shoulder pain (−2.51; −3.56 to −1.47). Conclusions The program effectively reduced headache and neck/shoulder pain in a large working community and appears to be easily transferable to primary-care settings. Further trials are needed to investigate the program effectiveness in a clinical setting, for highly selected patients suffering from specific headache types. Trial Registration ClinicalTrials.gov NCT00551980
Understanding the Mechanisms of Proteinuria: Therapeutic Implications

A large body of evidence indicates that proteinuria is a strong predictor of morbidity, a cause of inflammation, oxidative stress and progression of chronic kidney disease, and development of cardiovascular disease. The processes that lead to proteinuria are complex and involve factors such as glomerular hemodynamic, tubular absorption, and diffusion gradients. Alterations in various different molecular pathways and interactions may lead to the identical clinical end points of proteinuria and chronic kidney disease. Glomerular diseases include a wide range of immune and nonimmune insults that may target and thus damage some components of the glomerular filtration barrier. In many of these conditions, the renal visceral epithelial cell (podocyte) responds to injury along defined pathways, which may explain the resultant clinical and histological changes. The recent discovery of the molecular components of the slit diaphragm, specialized structure of podocyte-podocyte interaction, has been a major breakthrough in understanding the crucial role of the epithelial layer of the glomerular barrier and the pathogenesis of proteinuria. This paper provides an overview and update on the structure and function of the glomerular filtration barrier and the pathogenesis of proteinuria, highlighting the role of the podocyte in this setting. In addition, current antiproteinuric therapeutic approaches are briefly commented.
Bidirectional thermotaxis in Caenorhabditis elegans is mediated by distinct sensorimotor strategies driven by the AFD thermosensory neurons

Significance The nematode Caenorhabditis elegans offers the opportunity to map complex behaviors to the specific roles of each neuron in a 302-neuron nervous system. Thermotaxis is a complex behavior where the worm inverts the behavioral mode—positive thermotaxis up gradients or negative thermotaxis down gradients—to move toward a remembered temperature. How are both long-term memory and multiple behavioral modes encoded? A long-standing model has been that separate circuits for positive and negative thermotaxis compete for control of body movement. In contrast, we find that different modes of thermotaxis are driven by one set of AFD thermosensory neurons. Circuits for different thermotactic behaviors diverge from the AFD neurons, probably by coupling sensory inputs to motor programs in different ways to create different thermotactic behaviors. The nematode Caenorhabditis elegans navigates toward a preferred temperature setpoint (Ts) determined by long-term temperature exposure. During thermotaxis, the worm migrates down temperature gradients at temperatures above Ts (negative thermotaxis) and performs isothermal tracking near Ts. Under some conditions, the worm migrates up temperature gradients below Ts (positive thermotaxis). Here, we analyze positive and negative thermotaxis toward Ts to study the role of specific neurons that have been proposed to be involved in thermotaxis using genetic ablation, behavioral tracking, and calcium imaging. We find differences in the strategies for positive and negative thermotaxis. Negative thermotaxis is achieved through biasing the frequency of reorientation maneuvers (turns and reversal turns) and biasing the direction of reorientation maneuvers toward colder temperatures. Positive thermotaxis, in contrast, biases only the direction of reorientation maneuvers toward warmer temperatures. We find that the AFD thermosensory neuron drives both positive and negative thermotaxis. The AIY interneuron, which is postsynaptic to AFD, may mediate the switch from negative to positive thermotaxis below Ts. We propose that multiple thermotactic behaviors, each defined by a distinct set of sensorimotor transformations, emanate from the AFD thermosensory neurons. AFD learns and stores the memory of preferred temperatures, detects temperature gradients, and drives the appropriate thermotactic behavior in each temperature regime by the flexible use of downstream circuits.
Characterization of the male ApcMin/+ mouse as a hypogonadism model related to cancer cachexia

Summary Cancer cachexia, the unintentional loss of lean body mass, is associated with decreased quality of life and poor patient survival. Hypogonadism, involving a reduction in circulating testosterone, is associated with the cachectic condition. At this time there is a very limited understanding of the role of hypogonadism in cancer cachexia progression. This gap in our knowledge is related to a lack of functional hypogonadal models associated with cancer cachexia. The ApcMin/+ mouse is an established colorectal cancer model that develops an IL-6 dependent cachexia which is physiologically related to human disease due to the gradual progression of tumor development and cachexia. The purpose of this study was to assess the utility of the ApcMin/+ mouse for the examination of hypogonadism during cancer cachexia and to investigate if IL-6 has a role in this process. We report that ApcMin/+ mice that are weight stable have comparable testosterone levels and gonad size compared to wild type mice. Cachectic ApcMin/+ mice exhibit a reduction in circulating testosterone and gonad size, which has a significant association with the degree of muscle mass and functional strength loss. Circulating testosterone levels were also significantly associated with the suppression of myofibrillar protein synthesis. Skeletal muscle and testes androgen receptor expression were decreased with severe cachexia. Although testes STAT3 phosphorylation increased with severe cachexia, systemic IL-6 over-expression for 2 weeks was not sufficient to reduce either testes weight or circulating testosterone. Inhibition of systemic IL-6 signaling by an IL-6 receptor antibody to ApcMin/+ mice that had already initiated weight loss was sufficient to attenuate a reduction in testes size and circulating testosterone. In summary, the ApcMin/+ mouse becomes hypogonadal with the progression of cachexia severity and elevated circulating IL-6 levels may have a role in the development of hypogonadism during cancer cachexia.
High‐pressure minerals in shocked meteorites

Heavily shocked meteorites contain various types of high‐pressure polymorphs of major minerals (olivine, pyroxene, feldspar, and quartz) and accessory minerals (chromite and Ca phosphate). These high‐pressure minerals are micron to submicron sized and occur within and in the vicinity of shock‐induced melt veins and melt pockets in chondrites and lunar, howardite–eucrite–diogenite (HED), and Martian meteorites. Their occurrence suggests two types of formation mechanisms (1) solid‐state high‐pressure transformation of the host‐rock minerals into monomineralic polycrystalline aggregates, and (2) crystallization of chondritic or monomineralic melts under high pressure. Based on experimentally determined phase relations, their formation pressures are limited to the pressure range up to ~25 GPa. Textural, crystallographic, and chemical characteristics of high‐pressure minerals provide clues about the impact events of meteorite parent bodies, including their size and mutual collision velocities and about the mineralogy of deep planetary interiors. The aim of this article is to review and summarize the findings on natural high‐pressure minerals in shocked meteorites that have been reported over the past 50 years.
Patient and referring health care provider satisfaction with a physiotherapy spinal triage assessment service

Purpose To evaluate participant and referring care provider satisfaction associated with a spinal triage assessment service delivered by physiotherapists in collaboration with orthopedic surgeons. Methods People with low back-related complaints were recruited from those referred to a spinal triage assessment program delivered by physiotherapists. Measures of patient and provider satisfaction were completed at approximately 4 weeks after the assessment. The satisfaction surveys were analyzed quantitatively with descriptive statistics and qualitatively with an inductive thematic approach of open and axial coding. Results A total of 108/115 participants completed the posttest satisfaction survey. Sixty-six percent of participants were “very satisfied” with the service and 55% were “very satisfied” with the recommendations that were made. Only 18% of referring care providers completed the satisfaction survey and 90.5% of those were “very satisfied” with the recommendations. Sixty-one participants and 14 care providers provided comments which revealed a diverse range of themes which were coded into positive (ie, understanding the problem, communication, customer service, efficiency, and management direction), negative (ie, lack of detail, time to follow-up, cost) and neutral related to the triage service, and an “other” category unrelated to the service (ie, chronic symptoms, comorbidities, and limited access to health care.) Conclusion The quantitative results of the participant survey demonstrated very high levels of satisfaction with the service and slightly less satisfaction with the recommendations that were made. Satisfaction of referring care providers with the recommendations and report was also high, but given the low response rate, these results should be interpreted with caution. Qualitative analysis of participant and provider comments revealed a diverse range of themes. These other issues may be important contextual factors that have the potential to impact patient relevant outcomes.
Optical monitoring of the gravitationally lensed quasar Q2237+0305 from APO between June 1995 and January 1998

We present a data set of images of the gravitationally lensed quasar Q2237+0305, that was obtained at the Apache Point Observatory (APO) between June 1995 and January 1998. Although the images were taken under variable, often poor seeing conditions and with coarse pixel sampling, photometry is possible for the two brighter quasar images A and B with the help of exact quasar image positions from HST observations. We obtain a light curve with 73 data points for each of the images A and B. There is evidence for a long (>100 day) brightness peak in image A in 1996 with an amplitude of about 0.4 to 0.5 mag (relative to 1995), which indicates that microlensing has been taking place in the lensing galaxy. Image B does not vary much over the course of the observation period. The long, smooth variation of the light curve is similar to the results from the OGLE monitoring of the system (Wozniak et al. 2000a).
Prediction in social path following

Path following in games mostly focuses on avoiding collisions with dynamic physical objects that appear along a chosen path to a given destination. Some work also attempts to humanize the abstract path returned by a path finding algorithm through methods like smoothing. Games typically do not consider social factors during path following, even though many depict social environments. Social path following considers the social environment in particular, carving a trajectory that reflects awareness of other human beings and their social activities. This includes awareness of territories that have social significance but no concrete physical form, such as the space between those having a conversation. This paper describes work that extends a state-of-the-art predictive method for path following with social awareness, predicting and avoiding social collisions. The work builds on a platform for social simulation, which already models social territoriality and gaze behavior. The results appear promising and highlight the importance of perceiving and dealing with the social space along with the physical one.
From Traction to Friction in Thailand: The Emerging Southeast Asian Development Problematique

Abstract Using the notion of an emerging development problematique in Southeast Asia, this paper uses Thailand to argue that the development challenge is not being solved by economic growth, but reworked. Furthermore, while the policy aims of the early development era could be quite easily identified, measured and addressed, those that have emerged since the Millennium have proved to be more difficult to specify and less amenable to resolution. Drawing on village studies in northeast Thailand, this paper argues that the social adjustments and perturbations engendered by development have created second-order, often more intractable problems and challenges. In this way, the development traction of the early development decades has frequently turned into friction, with the state and its planning and development agencies increasingly struggling to meet both their own objectives and the aspirations of those for whom development was intended. It is also argued that Thailand's problematique is reflected in three emerging gaps: a development gap between what the Thai government is attempting to achieve and the willingness of the Thai population to join in that journey; a political gap reflected in Thailand's Red Shirt/Yellow Shirt conflict; and an aspirational gap between what has been achieved and what is aspired to.
Code compression based on operand factorization

This paper proposes a code compression technique called operand factorization. The central idea of operand factorization is the separation of program expression trees into sequences of tree-patterns (opcodes) and operand patterns (registers and immediates). Using this technique, we show that tree and operand patterns have exponential frequency distributions. A set of experiments were designed to explore this feature. They reveal an average compression ratio of 43% for SPECInt95 programs. A decompression engine is proposed, which assembles tree and operand patterns into uncompressed instruction sequences. An encoding that improves the design of the decompression engine results in a 48% compression ratio. Compression ratio numbers take into consideration an estimate of the decompression engine size.