Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of Air‐Sea Environmental Conditions and Interfacial Processes on Extremely Intense Typhoon Haiyan (2013)

Typhoon Haiyan (2013) intensified rapidly and reached a central pressure of 895 hPa over the warm northwestern Pacific. To clarify why Haiyan became such an extraordinarily intense tropical cyclone (TC), we investigated the impacts of atmospheric and oceanic conditions and air‐sea interfacial processes on Haiyan's intensity. We performed ensemble experiments with many different initial oceanic conditions and a 7‐km‐mesh atmosphere‐wave‐ocean coupled model. We also performed sensitivity experiments to examine the impacts of sea spray and use of a 2‐km‐mesh horizontal resolution. Also, analogous experiments were performed with Typhoon Mike (1990), which followed a similar track but was less intense than Haiyan. For both TCs, ocean coupling helped alleviate uncertainty in the simulated intensities caused by different preexisting oceanic conditions. Increases in air‐sea latent heat fluxes helped increase the intensity of both TCs although the effect of sea spray depended on whitecap coverage. Preexisting oceanic conditions and air‐sea interfacial processes directly affected the secondary circulation via changes in latent heat fluxes and near‐surface moisture influxes. However, the 2‐km‐mesh resolution improved only Haiyan's simulation; the mean latent heat flux over the strength area was insufficient to simulate the intensity. It was easterly winds and specific humidity at 850 hPa that determined the small size, rapid translation, less sea surface cooling, and small decreases in latent heat fluxes beneath the frictional convergence area of simulated Haiyan. Understanding of the effect of preexisting oceanic conditions and air‐sea interfacial processes on simulated TCs will serve as a guideline for improvement of the atmosphere‐wave‐ocean coupled model.
Warming of SE Greenland shelf waters in 2016 primes large glacier
for runaway retreat

Abstract. Kangerdluqssuaq Glacier in south-east Greenland has now retreated further inland than at any time in the past 33 years and is fast approaching a region of retrograde bedslope, meaning that continued rapid retreat is likely. Here we show that the current retreat was driven by anomalously warm surface water on the continental shelf during 2016. The warm surface water likely penetrated the fjord and weakened the mixture of sea ice and icebergs known as mélange, which is normally rigid enough to inhibit calving in winter. As Kangerdlugssuaq Glacier continued to calve almost continuously throughout 2017 and 2018 it accelerated by 35 % and thinned by 35 m.
Sprouting and synapse formation produced by Carbocaine

Injury to one cutaneous pectoris nerve of the frog induces sprouting of and synapse formation by the contralateral homologous intact nerve. It was previously suggested that axotomy initiates a signal for growth in the cell bodies of the injured motor neurons and that this signal is transferred transneuronally across the spinal cord to intact motor neurons (e.g., Rotshenker, S. (1982) J. Neurosci. 2: 1359–1368). The present study was designed to test the hypothesis that axotomy initiated the signal for growth by depriving neuronal somata of a trophic substance derived from the target muscle. The superficial layer of muscle fibers comprising one cutaneous pectoris muscle, the source of the hypothetical trophic substance, was removed by means of local application of the myotoxic local anesthetic Carbocaine. An increased supernumerary pattern of innervation developed in drug-treated muscles first and in contralateral intact muscles thereafter. These results raise the possibility that target muscle fibers play a role as regulators of a signal for growth in the cell bodies of their innervating motor neurons.
Multi-experts for touching digit string recognition

84.6% of touching digit strings have only two digits touching, 12.3% have three digits touching and 3.1% have more than three digits touching. We present a multi-expert approach to recognize touching digit pairs (TDP) and touching digit triples (TDT). We combine holistic and traditional segmentation methods. 25,686 TDP training samples and 2,778 TDP testing samples collected from USPS mail are used in our experiment. The holistic method outperforms the traditional segmentation-based methods. The multi-expert combination has the best performance: a correct recognition rate of 91.1% on TDP.
A Survey of Multi-Agent based Intelligent Decision Support System for Medical Classification Problems

has been growing on big data since last decade for discovering useful trends or patterns that are used in diagnosis and decision making. Intelligent decision support system an automated judgment that supports decision making is composed of human and computer interaction to help in decision making accuracy. Also multi-agent systems (MAS) are collections of independent intelligent entities that collaborate in the joint resolution of a complex problem. Multi-agent intelligent decision support systems can be used to solve large-scale convention problem. This paper is a survey of the recent research in multi- agent and intelligent decision support systems to support for classification problems. The purpose of the survey described in this paper is the development of a novel large-scale hybrid medical diagnosis system based on Multi-agent Intelligent Decision Support System (IDSS) for distributed database.
Human single-nucleotide polymorphisms alter p53 sequence-specific binding at gene regulatory elements

p53 coordinates the expression of an intricate network of genes in response to stress signals. Sequence-specific DNA binding is essential for p53-mediated tumor suppression. We evaluated the impact of single-nucleotide polymorphisms (SNPs) in p53 response elements (p53RE) on DNA binding and gene expression in response to DNA damage. Using a bioinformatics approach based on incorporating p53 binding strength into a position weight matrix, we selected 32 SNPs in putative and validated p53REs. The microsphere assay for protein–DNA binding (MAPD) and allele-specific expression analysis was employed to assess the impact of SNPs on p53-DNA binding and gene expression, respectively. Comparing activated p53 binding in nuclear extracts from doxorubicin- or ionizing radiation (IR)-treated human cells, we observed little difference in binding profiles. Significant p53 binding was observed for most polymorphic REs and several displayed binding comparable to the p21 RE. SNP alleles predicted to lower p53 binding indeed reduced binding in 25 of the 32 sequences. Chromatin immunoprecipitation-sequencing in lymphoblastoid cells confirmed p53 binding to seven polymorphic p53 REs in response to doxorubicin. In addition, five polymorphisms were associated with altered gene expression following doxorubicin treatment. Our findings demonstrate an effective strategy to identify and evaluate SNPs that may alter p53-mediated stress responses.
Critical appraisal of omega-3 fatty acids in attention-deficit/hyperactivity disorder treatment

Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder. The classical treatment of ADHD where stimulant medication is used has revealed severe side effects and intolerance. Consequently, the demand to search for alternative treatment has increased rapidly. When comparing levels of omega-3 polyunsaturated fatty acids (ω-3 PUFAs) in ADHD patients with those in age-matching controls, lower levels are found in ADHD patients’ blood. ω-3 PUFAs are essential nutrients and necessary for a proper brain function and development. Additionally, there are strong indications that ω-3 PUFA supplements could have beneficial effects on ADHD. However, the results of ω-3 PUFA supplementation studies show a high variability. Therefore, we reviewed recent studies published between 2000 and 2015 to identify effective treatment combinations, the quality of design, and safety and tolerability of ω-3-containing food supplements. We searched the databases MEDLINE, PubMed, and Web of Science with keywords such as “ADHD” and “ω-3/6 PUFA” and identified 25 studies that met the inclusion and exclusion criteria. The results of these ω-3 PUFA studies are contradictory but, overall, show evidence for a successful treatment of ADHD symptoms. Tolerability of the given supplements was high, and only mild side effects were reported. In conclusion, there is evidence that a ω-3 PUFA treatment has a positive effect on ADHD. It should be added that treatment could be more effective in patients with mild forms of ADHD. Moreover, the dosage of stimulant medication could be reduced when used in combination with ω-3 PUFA supplements. Further studies are necessary to investigate underlying mechanisms that can lead to a reduction of ADHD symptoms due to ω-3 PUFA treatments and also to determine the optimal concentrations of ω-3 PUFAs, whether used as single treatment or in combination with other medication.
An information-theoretic framework for resolving community structure in complex networks

To understand the structure of a large-scale biological, social, or technological network, it can be helpful to decompose the network into smaller subunits or modules. In this article, we develop an information-theoretic foundation for the concept of modularity in networks. We identify the modules of which the network is composed by finding an optimal compression of its topology, capitalizing on regularities in its structure. We explain the advantages of this approach and illustrate them by partitioning a number of real-world and model networks.
Body composition in HIV-infected patients receiving highly active antiretroviral therapy

Background: The development of combination antiretroviral therapies (cART) represents a significant advance in the treatment of (human immunodeficiency virus) HIV infection. However, several studies report that a large percentage of individuals with HIV, particularly those receiving cART, present body composition differences compared with the general population. The aim of this study was to explore body composition differences by dual-energy X-ray absorptiometry (DEXA), among HIV-positive patients receiving cART, in comparison to healthy controls. Methods: The cross-sectional study included 60 HIV-infected patients (all under 50 years old). We analyzed the association of antiretroviral medication use and different HIV-related factors, to the body composition parameters. Results: Our cohort had significantly lower fat mass and lower bone mass compared to non HIV-infected persons. Median time since HIV infection diagnosis was 5 years (interquartile range, [IQR], 2–10.25) and viral suppression was achieved in 49 (81.66%) patients. Treatment with protease inhibitors (PIs) was strongly correlated with low fat mass, reduced lean mass and loss of bone mineral density. Nucleoside reverse transcriptase inhibitors (NRTIs)-containing treatment was associated with decrease of lean tissue mass (LM). The prevalence of osteopenia was 41.67% at the lumbar spine (L1–L4) and 36.7% at the hip. We found osteoporosis in 10% of the patients at the lumbar spine. Reduced bone mass was associated, in the patient group, with the duration of PIs use and with smoking (in the males group). Conclusion: In our research, HIV-infected individuals compared to healthy controls had body composition differences, including fat mass atrophy and reduced bone mineral content.
GSICS Inter-Calibration of Infrared Channels of Geostationary Imagers Using Metop/IASI

The first products of the Global Space-based Inter-Calibration System (GSICS) include bias monitoring and calibration corrections for the thermal infrared (IR) channels of current meteorological sensors on geostationary satellites. These use the hyperspectral Infrared Atmospheric Sounding Interferometer (IASI) on the low Earth orbit (LEO) Metop satellite as a common cross-calibration reference. This paper describes the algorithm, which uses a weighted linear regression, to compare collocated radiances observed from each pair of geostationary-LEO instruments. The regression coefficients define the GSICS Correction, and their uncertainties provide quality indicators, ensuring traceability to the selected community reference, IASI. Examples are given for the Meteosat, GOES, MTSAT, Fengyun-2, and COMS imagers. Some channels of these instruments show biases that vary with time due to variations in the thermal environment, stray light, and optical contamination. These results demonstrate how inter-calibration can be a powerful tool to monitor and correct biases, and help diagnose their root causes.
Defense Mechanisms of Hepatocytes Against Burkholderia pseudomallei

The Gram-negative facultative intracellular rod Burkholderia pseudomallei causes melioidosis, an infectious disease with a wide range of clinical presentations. Among the observed visceral abscesses, the liver is commonly affected. However, neither this organotropism of B. pseudomallei nor local hepatic defense mechanisms have been thoroughly investigated so far. Own previous studies using electron microscopy of the murine liver after systemic infection of mice indicated that hepatocytes might be capable of killing B. pseudomallei. Therefore, the aim of this study was to further elucidate the interaction of B. pseudomallei with these cells and to analyze the role of hepatocytes in anti-B. pseudomallei host defense. In vitro studies using the human hepatocyte cell line HepG2 revealed that B. pseudomallei can invade these cells. Subsequently, B. pseudomallei is able to escape from the vacuole, to replicate within the cytosol of HepG2 cells involving its type 3 and type 6 secretion systems, and to induce actin tail formation. Furthermore, stimulation of HepG2 cells showed that IFNγ can restrict growth of B. pseudomallei in the early and late phase of infection whereas the combination of IFNγ, IL-1β, and TNFα is required for the maximal antibacterial activity. This anti-B. pseudomallei defense of HepG2 cells did not seem to be mediated by inducible nitric oxide synthase-derived nitric oxide or NADPH oxidase-derived superoxide. In summary, this is the first study describing B. pseudomallei intracellular life cycle characteristics in hepatocytes and showing that IFNγ-mediated, but nitric oxide- and reactive oxygen species-independent, effector mechanisms are important in anti-B. pseudomallei host defense of hepatocytes.
Quality Of Life among Caregivers of Elderly With Dementia and Its Associated Factors

Dementia is a progressive illness and it imposed a great challenge for the caregivers. The daunting tasks have an impact to the quality of life of these caregivers. Methods:A cross sectional study was conducted in five major hospitals in Sarawak, Malaysia,from June until December 2011. The objectives were to determine the quality of life among informal primary caregiversof elderly diagnosed with dementia and its associated factors.The respondents were informal primary caregivers of dementia patients who were on follow-up at the psychiatric clinic in five selected hospitals. They were recruited purposively from a list of elderly dementia cases. Guided interview was carried out either during clinic appointment or home visit for those who were not present during clinic follow-up. A set of questionnaire including socio-demographic characteristics, caregiving characteristics, patient characteristicsand SF 36 questionnaire for measurement of quality of life was administered. Results:Hundred forty five primary caregivers were interviewed. They had significant poor physical composite score (PCS) as compared to mental composite score (MCS (p<0.05)). Behaviour problem among patientsand being a Chinese carer were significantly associated with poor mental score (p<0.05). Meanwhile being unemployed (p<0.05) and taking care of severe type of dementia patients (p<0.05) were significantly associated with poor physical score. Conclusion: Dementia caregivers, experiencing poor physical and mental health. It was associated withChinese race, behaviour problems of the patients,employment statusand type of dementia.
Influence of body hair removal on physiological responses during breaststroke swimming.

Nine male collegiate swimmers (EXP) were studied 8 d before (PRE) and 1 d after (POST) shaving the hair from their arms, legs, and exposed trunk. A control group (CON, N = 4) of their teammates was also tested at these times but did not remove body hair. In PRE and POST, distance per stroke (SL), VO2, heart rate (HR), and post-swim blood lactate concentration (BL) were measured during a 365.8 m breaststroke swim at approximately 90% effort. Subjects also performed a tethered breaststroke swim with retarding forces of 6.27, 7.75, and 9.26 kg. The EXP group experienced a significant (P less than 0.05) reduction in BL (mean +/- SE: 8.48 +/- 0.78 to 6.74 +/- 0.74 mmol.l-1), a decreased VO2 (3.60 +/- 0.15 to 3.27 +/- 0.14 l.min-1), an increase in SL (2.07 +/- 0.08 to 2.31 +/- 0.10 m.stroke-1), and an insignificant (P = 0.08) decline in HR (174 +/- 5 to 168 +/- 4 beats.min-1) during the free swim. The CON group showed no changes in BL, SL, or HR. During the tethered swim, there were no significant PRE-POST differences in VO2, HR, or BL for either group. In a separate group of swimmers (nine who shaved body hair and nine controls), removing body hair significantly reduced the rate of velocity decay during a prone glide after a maximal underwater leg push-off. It is concluded that removing body hair reduces active drag, thereby decreasing the physiological cost of swimming.
Physical Training Increases eNOS Vascular Expression and Activity and Reduces Restenosis After Balloon Angioplasty or Arterial Stenting in Rats

Abstract— The effects of dynamic exercise on restenosis after vascular injury are still unknown. The consequences of balloon dilation–induced injury on neointimal hyperplasia, vascular negative remodeling, and reendothelialization were assessed in sedentary and trained rats. Ex vivo eNOS vascular expression and activity were investigated in carotid arteries isolated from sedentary and exercised rats. The in vivo effects of eNOS inhibition by L-NMMA on vessel wall after balloon dilation were evaluated in sedentary and exercised rats. We also investigated the effects of exercise on neointimal formation in a rat stent model of vascular injury. Compared with sedentary group, the arteries isolated from trained rats showed higher levels of eNOS protein expression and activity 7 days after balloon dilation. A significant reduction of both neointimal hyperplasia and negative remodeling was observed 14 days after balloon injury in trained compared with sedentary rats. Moreover, we demonstrated that exercise training produced accelerated reendothelialization of the balloon injured arterial segments compared with sedentary. L-NMMA administration eliminated the benefits of physical training on vessel wall after balloon dilation. Finally, a decrease of neointimal hyperplasia as well as of platelet aggregation was observed after stent deployment in trained rats compared with sedentary. In conclusion, physical exercise could favorably affect restenosis after balloon angioplasty and stenting. Increase in eNOS expression and activity might contribute to the potential beneficial effects of exercise on the vessel wall after vascular injury.
Quality of information in academic e-mailing lists

The article analyzes how researchers evaluate the quality of information in Internet e-mailing lists and whether the embeddedness of academic e-mailing lists in offline networks of a scientific community is related to it. The idea is that embeddedness gives researchers more opportunities to build up a reputation through contributing high-quality information to the group. Survey and archive data are used to test hypotheses about the effects of offline networks in 47 academic e-mailing lists used by a random sample of university researchers. Results indicate that the information in embedded online groups is regarded as more valuable than in purely virtual groups.
High-Performance Prediction of Human Estrogen Receptor Agonists Based on Chemical Structures

Many agonists for the estrogen receptor are known to disrupt endocrine functioning. We have developed a computational model that predicts agonists for the estrogen receptor ligand-binding domain in an assay system. Our model was entered into the Tox21 Data Challenge 2014, a computational toxicology competition organized by the National Center for Advancing Translational Sciences. This competition aims to find high-performance predictive models for various adverse-outcome pathways, including the estrogen receptor. Our predictive model, which is based on the random forest method, delivered the best performance in its competition category. In the current study, the predictive performance of the random forest models was improved by strictly adjusting the hyperparameters to avoid overfitting. The random forest models were optimized from 4000 descriptors simultaneously applied to 10,000 activity assay results for the estrogen receptor ligand-binding domain, which have been measured and compiled by Tox21. Owing to the correlation between our model’s and the challenge’s results, we consider that our model currently possesses the highest predictive power on agonist activity of the estrogen receptor ligand-binding domain. Furthermore, analysis of the optimized model revealed some important features of the agonists, such as the number of hydroxyl groups in the molecules.
DSRTrust: A Dynamic Trust Model of Distinguishing Service and Recommendation for Internet-based Virtual Computing Environment

Internet-based virtual computing environments (iVCE) are open, anonymous and dynamic in nature. Such characteristics bring about threats and vulnerabilities in providing trusted services and improving resource utilization. Therefore, a dynamic trust model for distinguishing service and recommendation is proposed. In this paper, we analyze multidimensional decision factors related to the evaluation of autonomous node, such as user satisfaction, reward function, punishment function and time decay function. According to the network connection degree of node, our model assigns a new trust weight that specifically describes the relationship between network and trust in iVCE. We then propose a dynamic quantitative model for measuring different kinds of trust. Simulation results indicate that our model can effectively cope with malicious behavior and exhibits evident advantages in resource utilization compared with existing models.
Intracellular Distribution of a Biotin-labeled Ganglioside, GM1, by Immunoelectron Microscopy After Endocytosis in Fibroblasts

A radioactive and biotin-labeled analogue of GM1 (biotin-GM1) was synthesized which enabled us to analyze its intracellular distribution in the compartments of the endocytic route by electron microscopic immunocytochemistry using thin sections of human skin fibroblasts labeled with gold-conjugated antibiotin antibodies. Metabolic studies with the biotin-GM1 showed its partial degradation to the corresponding GM2 and GM3 derivatives. Further degradation was inhibited by the biotin residue. The distribution of biotin-GM1 after uptake by cells was studied by postembedding labeling techniques. On the plasma membrane the biotin-GM1 was detectable in the form of patches (0.1 μm in diameter), in caveola-like structures and, to a much lesser extent, in coated pits or vesicles. During endocytic uptake, the biotin-GM1 became detectable in organelles identified as late endosomes and lysosomes. The intracellular distribution of the biotin-GM1 was compared to the localization of the EGF receptor in EGF-stimulated fibroblasts. Both the biotin-GM1 and the EGF receptor were transported to intraendosomal and intralysosomal membranes, indicating that both membrane constituents follow the same pathway of endocytosis. Our observations show that biotin-GM1 can be successfully incorporated into the plasma membrane and be used as a tool for morphological detection of its pathway to lysosomes. (J Histochem Cytochem 47:1005–1014, 1999)