Miracle-dz/UniFAR-FTUs huggingface dataset:
Large-Scale Sentiment Analysis for News and Blogs (system demonstration)

Newspapers and blogs express opinion of news entities (people, places, things) while reporting on recent events. We present a system that assigns scores indicating positive or negative opinion to each distinct entity in the text corpus. Our system consists of a sentiment identication phase, which associates expressed opinions with each relevant entity, and a sentiment aggregation and scoring phase, which scores each entity relative to others in the same class. Finally, we evaluate the signicance of our scoring techniques over large corpus of news and blogs.
PRB1 Is Required for Clipping of the Histone H3 N Terminal Tail in Saccharomyces cerevisiae

Cathepsin L, a lysosomal protein in mouse embryonic stem cells has been shown to clip the histone H3 N- terminus, an activity associated with gene activity during mouse cell development. Glutamate dehydrogenase (GDH) was also identified as histone H3 specific protease in chicken liver, which has been connected to gene expression during aging. In baker’s yeast, Saccharomyces cerevisiae, clipping the histone H3 N-terminus has been associated with gene activation in stationary phase but the protease responsible for the yeast histone H3 endopeptidase activity had not been identified. In searching for a yeast histone H3 endopeptidase, we found that yeast vacuolar protein Prb1 is present in the cellular fraction enriched for the H3 N-terminus endopeptidase activity and this endopeptidase activity is lost in the PRB1 deletion mutant (prb1Δ). In addition, like Cathepsin L and GDH, purified Prb1 from yeast cleaves H3 between Lys23 and Ala24 in the N-terminus in vitro as shown by Edman degradation. In conclusion, our data argue that PRB1 is required for clipping of the histone H3 N-terminal tail in Saccharomyces cerevisiae.
Stability of Fuzzy Differential Equations With the Second Type of Hukuhara Derivative

In this paper, we consider fuzzy differential equations with the second type of Hukuhara derivative. With the help of Lyapunov-like functions, we establish stability, uniform stability, and uniformly asymptotical stability theorems, respectively, for a class of fuzzy differential equations with the second type of Hukuhara derivative. Besides, a very useful comparison principle is derived, which connects the stability relationships between fuzzy differential equations with the second type of Hukuhara derivative and scalar differential equations. In addition, some examples are shown to illustrate the effectiveness of the results.
Quiescence unveils a novel mutational force in fission yeast

One Sentence Summary The quiescence-driven mutational landscape reveals a novel evolutionary force. Abstract During cell division, the spontaneous mutation rate is expressed as the probability of mutations per generation, whereas during quiescence it will be expressed per unit of time. In this study, we report that during quiescence, the unicellular haploid fission yeast accumulates mutations as a linear function of time. We determined that 3 days of quiescence generate a number of invalidating mutations equivalent to that of one round of DNA replication. The novel mutational landscape of quiescence is characterized by insertion/deletion accumulating as fast as single nucleotide variants, and elevated amounts of deletions. When we extended the study to 3 months of quiescence, we confirmed the replication-independent mutational spectrum at the whole-genome level of a clonally aged population and uncovered phenotypic variations that subject the cells to natural selection. Thus, our results support the idea that genomes continuously evolve under two alternating phases that will impact on their size and composition.
Repeatability of measurements of oxygen consumption, heart rate and Borg's scale in men during ergometer cycling

The coefficient of repeatability (COR), expressed as 2 SD of differences, was calculated between two measurements of oxygen consumption ( ), heart rate (HR) and rating of perceived exertion (RPE) during ergometer cycling by men. The two sets of measurements were performed 5 to 6 weeks apart. Nineteen healthy men performed an incremental maximal exercise test on an ergometer cycle. The load started at 50 W and increased by 5 W 20 s−1 until exhaustion was reached. At 40% of the individual maximum load of the pretest, the load was kept constant for 4 min in order to reach steady state. Gas measurements were recorded continuously by computerized instrumentation. The HR was monitored with electrocardiography (ECG) and the perceived exertion was evaluated using Borg's scale. The COR of at sub‐maximal load was 14% and at maximum load 11%. The values in absolute figures were 209 and 332 ml min−1. The corresponding COR of the HR was 16% at sub‐maximum load and 6% at maximum load, and an evaluation of the perceived exertion yielded CORs in absolute values of 4·8 and 1·3, respectively. The COR for , HR and ratings of perceived exertion when cycling on an ergometer cycle thus indicate a better agreement between the measurements at maximum load. The COR of the heart at sub‐maximal loads must be kept in mind when using HR for estimation of . The reported findings should be considered when using tests on an ergometer cycle for evaluating exercise capacity.
Duality and quasi-normability for complexity spaces

The complexity (quasi-metric) space was introduced in [23] to study complexity analysis of programs. Recently, it was introduced in [22] the dual complexity (quasi-metric) space, as a subspace of the function space [0,) ω . Several quasi-metric properties of the complexity space were obtained via the analysis of its dual. We here show that the structure of a quasi-normed semilinear space provides a suitable setting to carry out an analysis of the dual complexity space. We show that if (E,) is a biBanach space (i.e., a quasi-normed space whose induced quasi-metric is bicomplete), then the function space (B* E , B* ) is biBanach, where B* E = {f : E Σ ∞ n=0 2 -n ( V ) } and B* = Σ ∞ n=0 2 -n We deduce that the dual complexity space admits a structure of quasinormed semlinear space such that the induced quasi-metric space is order-convex, upper weightable and Smyth complete, not only in the case that this dual is a subspace of [0,) ω but also in the general case that it is a subspace of F ω where F is any biBanach normweightable space. We also prove that for a large class of dual complexity (sub)spaces, lower boundedness implies total boundedness. Finally, we investigate completeness of the quasi-metric of uniform convergence and of the Hausdorff quasi-pseudo-metric for the dual complexity space, in the context of function spaces and hyperspaces, respectively.
Fas-, Caspase 8-, and Caspase 3-dependent Signaling Regulates the Activity of the Aminophospholipid Translocase and Phosphatidylserine Externalization in Human Erythrocytes*

Apoptosis and erythrocyte senescence share the common feature of exposure of phosphatidylserine (PS) in the outer leaflet of the cells. Western analysis showed that mature red cells contain Fas, FasL, Fas-associated death domain (FADD), caspase 8, and caspase 3. Circulating, aged cells showed colocalization of Fas with the raft marker proteins Gαs and CD59; the existence of Fas-associated FasL, FADD and caspase 8; and caspase 8 and caspase 3 activity. Aged red cells had significantly lower aminophospholipid translocase activity and higher levels of PS externalization in comparison with young cells. In support of our contention that caspases play a functional role in the mature red cell, the oxidatively stressed red cell recapitulated apoptotic events, including translocation of Fas into rafts, formation of a Fas-associated complex, and activation of caspases 8 and 3. These events were independent of calpain but dependent on reactive oxygen species (ROS) as evident from the effects of the ROS scavenger N-acetylcysteine. Caspase activation was associated with loss of aminophospholipid translocase activity and with PS externalization. ROS was not generated by treatment of cells with t-butyl hydroperoxide at 10 °C, and Fas did not translocate into rafts. Concomitantly, neither formation of a Fas-associated signaling complex nor caspase activation could be observed, supporting the view that translocation of Fas into rafts was the trigger for the chain of events leading to caspase 3 activation. Our data demonstrate for the first time the novel involvement of Fas/caspase 8/caspase 3-dependent signaling in an enucleated cell leading to PS externalization, a central feature of erythrophagocytosis and erythrocyte biology.
On capacity of noncoherent MIMO with asymmetric link strengths

We study the generalized degrees of freedom (gDoF) of the block-fading noncoherent MIMO channel with asymmetric distributions of link strengths, and a coherence time of T symbol durations. We first derive the optimal signaling structure for communication over this channel, which is distinct from that for the i.i. d MIMO setting. We prove that for T = 1, the gDoF is zero for MIMO channels with arbitrary link strength distributions, extending the result for MIMO with i.i. d links. We then show that selecting the statistically best antenna is gDoF-optimal for both Multiple Input Single Output (MISO) and Single Input Multiple Output (SIMO) channels. We also derive the gDoF for the 2×2 MIMO channel with different exponents in the direct and cross links. In this setting, we show that it is always necessary to use both antennas to achieve the optimal gDoF, in contrast to the results for 2 × 2 MIMO with identical link distributions. We also show that having weaker crosslinks gives gDoF gain compared to the case with identically distriuted links.
Accurate and Rapid Differentiation of Acinetobacter baumannii Strains by Raman Spectroscopy: a Comparative Study

ABSTRACT In recent years, matrix-assisted laser desorption ionization–time of flight mass spectrometry (MALDI-TOF MS) has become the standard for routine bacterial species identification due to its rapidity and low costs for consumables compared to those of traditional DNA-based methods. However, it has been observed that strains of some bacterial species, such as Acinetobacter baumannii strains, cannot be reliably identified using mass spectrometry (MS). Raman spectroscopy is a rapid technique, as fast as MALDI-TOF, and has been shown to accurately identify bacterial strains and species. In this study, we compared hierarchical clustering results for MS, genomic, and antimicrobial susceptibility test data to hierarchical clustering results from Raman spectroscopic data for 31 A. baumannii clinical isolates labeled according to their pulsed-field gel electrophoresis data for strain differentiation. In addition to performing hierarchical cluster analysis (HCA), multiple chemometric methods of analysis, including principal-component analysis (PCA) and partial least-squares discriminant analysis (PLSDA), were performed on the MS and Raman spectral data, along with a variety of spectral preprocessing techniques for best discriminative results. Finally, simple HCA algorithms were performed on all of the data sets to explore the relationships between, and natural groupings of, the strains and to compare results for the four data sets. To obtain numerical comparison values of the clustering results, the external cluster evaluation criteria of the Rand index of the HCA dendrograms were calculated. With a Rand index value of 0.88, Raman spectroscopy outperformed the other techniques, including MS (with a Rand index value of 0.58).
Multi-objective Flexible Job-Shop scheduling problem with DIPSO: More diversity, greater efficiency

The Flexible Job Shop Problem is one of the most important NP-hard combinatorial optimization problems. Evolutionary computation has been widely used in research concerning this problem due to its ability for dealing with large search spaces and the possibility to optimize multiple objectives. Particle Swarm Optimization has shown good results, but algorithms based on this technique have premature convergence, therefore some proposals have introduced genetic operators or other local search methods in order to avoid the local minima. Therefore, this paper presents a hybrid and multi-objective algorithm, Particle Swarm Optimization with Diversity (DIPSO), based on Particle Swarm Optimization along with genetic operators and Fast Non-dominated Sorting. Thus, to maintain a high degree of diversity in order to guide the search for a better solution while ensuring convergence, a new crossover operator has been introduced. The efficiency of this operator was tested in relation to the proposed objectives by using typical examples from literature. The results were compared to other studies that have shown good results by means Evolutionary Computation technique, for instance MOEA-GLS, MOGA, PSO + SA and PSO + TS.
GENERALIZED TRANSFORMATIONS AND THE THEORY OF GRAMMAR

The compositional approach to phrase structure proposed in Chomsky's ‘Minimalist Program’ paper (1992) can be implemented in various ways. This paper explores the use of Tree Adjoining Grammar (Kroch & Joshi 1985, 1986; Frank 1992, inter alia) as a formal mechanism for syntactic composition and compares it to the operations proposed in Chomsky (1992). The TAG approach avoids the need for distinguishing two modes of phrase structure composition, ‘GT’ and ‘adjunction’, and allows the elimination of the requirement ‘extension requirement’. Further, it permits a purely local interpretation of transformational movement and a simplification of the conception of derivational economy. It also has important consequences for the proper treatment of the binding and scope effects of successive cyclic movement.
Pharyngeal airway space, hyoid bone position, and head posture after bimaxillary orthognathic surgery in Class III patients: long-term evaluation.

OBJECTIVE (1) To determine the effect of bimaxillary orthognathic surgery on pharyngeal airway, hyoid bone, and craniocervical posture in Class III bimaxillary surgery patients. (2) To evaluate short-term and long-term results. (3) To compare short- and long-term values. MATERIALS AND METHODS Twenty-six Class III adult patients treated with bimaxillary surgery were included in the study. Cephalometric records were taken before treatment (T1), before surgery (T2), and 5 months (T3), 1.4 years (T4), 3 years (T5), and 5 years (T6) postsurgery. RESULTS No significant differences were identified in craniocervical angulation between time intervals. There was a significant superior movement of hyoid bone at postsurgery (T3; P < .05); however, adaptation occurred to the normal position in the long term. A nonsignificant decrease occurred at the oropharyngeal middle pharyngeal distance parameter; however, this was compensated with a significant increase between T5 and T6 (P < .001). A significant decrease was observed in the hypopharyngeal Go-P parameter between T3 and T1 (P < .01), but it recovered with a nonsignificant increase in the long term. A significant increase in nasopharyngeal area was observed between T3 and T1 (P < .05). The hypopharyngeal area significantly increased between T5 and T6, and PNS-R significantly increased between T3 and T1 (P < .05). CONCLUSION The pharyngeal areas adversely affected after surgery recover at long-term follow-up; thus, adaptation occurs after bimaxillary surgery.
Précis of Bayesian Rationality: The Probabilistic Approach to Human Reasoning

Abstract According to Aristotle, humans are the rational animal. The borderline between rationality and irrationality is fundamental to many aspects of human life including the law, mental health, and language interpretation. But what is it to be rational? One answer, deeply embedded in the Western intellectual tradition since ancient Greece, is that rationality concerns reasoning according to the rules of logic – the formal theory that specifies the inferential connections that hold with certainty between propositions. Piaget viewed logical reasoning as defining the end-point of cognitive development; and contemporary psychology of reasoning has focussed on comparing human reasoning against logical standards. Bayesian Rationality argues that rationality is defined instead by the ability to reason about uncertainty. Although people are typically poor at numerical reasoning about probability, human thought is sensitive to subtle patterns of qualitative Bayesian, probabilistic reasoning. In Chapters 1–4 of Bayesian Rationality (Oaksford & Chater 2007), the case is made that cognition in general, and human everyday reasoning in particular, is best viewed as solving probabilistic, rather than logical, inference problems. In Chapters 5–7 the psychology of “deductive” reasoning is tackled head-on: It is argued that purportedly “logical” reasoning problems, revealing apparently irrational behaviour, are better understood from a probabilistic point of view. Data from conditional reasoning, Wason's selection task, and syllogistic inference are captured by recasting these problems probabilistically. The probabilistic approach makes a variety of novel predictions which have been experimentally confirmed. The book considers the implications of this work, and the wider “probabilistic turn” in cognitive science and artificial intelligence, for understanding human rationality.
Topological Interference Management With User Admission Control via Riemannian Optimization

Topological interference management (TIM) provides a promising way to manage interference only based on the network connectivity information. Previous works on the TIM problem mainly focus on using the index coding approach and graph theory to establish conditions of network topologies to achieve the feasibility of topological interference management. In this paper, we propose a novel user admission control approach via sparse and low-rank optimization to maximize the number of admitted users for achieving the feasibility of topological interference management. However, the resulting sparse and low-rank optimization problem is non-convex and highly intractable, for which the <italic>conventional convex relaxation approaches</italic> are inapplicable, e.g., a simple <inline-formula> <tex-math notation="LaTeX">$\ell _{1}$ </tex-math></inline-formula>-norm relaxation approach yields the objective unbounded and non-convex. To assist efficient algorithms design for the formulated rank-constrained (i.e., degrees-of-freedom (DoFs) allocation) <inline-formula> <tex-math notation="LaTeX">$\ell _{0}$ </tex-math></inline-formula>-norm <italic>maximization</italic> (i.e., user capacity maximization) problem, we propose a novel <italic>non-convex</italic> but <italic>smoothed</italic> <inline-formula> <tex-math notation="LaTeX">$\ell _{1}$ </tex-math></inline-formula>-regularized minimization approach to induce sparsity pattern with bounded objective values. We further develop a Riemannian trust-region algorithm to solve the resulting rank-constrained smooth non-convex optimization problem via exploiting the quotient manifold of fixed-rank matrices. Simulation results demonstrate the effectiveness and optimality of the proposed Riemannian algorithm to maximize the number of admitted users for topological interference management.
Immunohistochemical molecular markers as predictors of curability of endoscopically resected submucosal colorectal cancer.

AIM To clarify the usefulness of immunohistochemical molecular markers in predicting lymph node metastasis of submucosal colorectal cancer. METHODS We examined microvessel density, lymphatic vessel density, the Ki-67 labeling index, expression of MUC1 and Matrix metalloproteinase-7 (MMP-7) in tumor cells, and expression of cathepsin D in stromal cells at the invasive front by immunostaining of samples resected from 214 patients with submucosal colorectal cancer. Pathologic features were assessed on hematoxylin-eosin-stained samples. We evaluated the relations between clinicopathologic/immunohistochemical features and lymph node metastasis. RESULTS Lesions of the superficial type, with an unfavorable histologic grade, budding, lymphatic involvement, high microvessel density (>or= 40), high lymphatic vessel density (>or= 9), high Ki-67 labeling index (>or= 42), and positivity of MUC1, cathepsin D, and MMP-7 showed a significantly high incidence of lymph node metastasis. Multivariate analysis revealed that high microvessel density, unfavorable histologic grade, cathepsin D positivity, high lymphatic vessel density, superficial type, budding, and MUC1 positivity were independent risk factors for lymph node metastasis. A combined examination with four independent immunohistochemical markers (microvessel density, cathepsin D, lymphatic vessel density, and MUC1) revealed that all lesions that were negative for all markers or positive for only one marker were negative for lymph node metastasis. CONCLUSION Analysis of a combination of immuno-histochemical molecular markers in endoscopically resected specimens of submucosal colorectal cancer allows prediction of curability regardless of the pathologic features visible of hematoxylin-eosin-stained sections.
Geographically Weighted Visualization: Interactive Graphics for Scale-Varying Exploratory Analysis

We introduce a series of geographically weighted (GW) interactive graphics, or geowigs, and use them to explore spatial relationships at a range of scales. We visually encode information about geographic and statistical proximity and variation in novel ways through gw-choropleth maps, multivariate gw-boxplots, gw-shading and scalograms. The new graphic types reveal information about GW statistics at several scales concurrently. We impement these views in prototype software containing dynamic links and GW interactions that encourage exploration and refine them to consider directional geographies. An informal evaluation uses interactive GW techniques to consider Guerry's dataset of 'moral statistics', casting doubt on correlations originally proposed through visual analysis, revealing new local anomalies and suggesting multivariate geographic relationships. Few attempts at visually synthesising geography with multivariate statistical values at multiple scales have been reported. The geowigs proposed here provide informative representations of multivariate local variation, particularly when combined with interactions that coordinate views and result in gw-shading. We argue that they are widely applicable to area and point-based geographic data and provide a set of methods to support visual analysis using GW statistics through which the effects of geography can be explored at multiple scales.