Miracle-dz/UniFAR-FTUs huggingface dataset:
Anabolic ornithine carbamoyltransferase of Pseudomonas aeruginosa: nucleotide sequence and transcriptional control of the argF structural gene

In Pseudomonas aeruginosa PAO the anabolic ornithine carbamoyltransferase (OTCase, EC 2.1.3.3) is the product of the argF gene and the only arginine biosynthetic enzyme whose synthesis is repressible by arginine. We have determined the complete nucleotide sequence of the argF gene including its promoter-control region. The deduced amino acid sequence of the anabolic OTCase consists of 305 residues (Mr 33,924), and this was confirmed by the N-terminal amino acid sequence, the total amino acid composition, and the subunit Mr of the purified enzyme. The native anabolic OTCase (Mr 110,000 to 125,000) was found to be a trimer by cross-linking experiments. P. aeruginosa also has a catabolic OTCase (the arcB gene product), which catalyzes the reverse reaction of the anabolic conversion. At the nucleotide sequence level, the P. aeruginosa argF gene had 52.4% identity with the arcB gene. The Escherichia coli argF and argI genes, which code for anabolic OTCase isoenzymes, had 47.3 and 44.9% identity, respectively, with the P. aeruginosa argF sequence. This suggests that these four genes have evolved from a common ancestral gene. The arcB gene appears to be more closely related to the E. coli argF gene than to the P. aeruginosa argF gene. Two transcripts (mRNA-1, mRNA-2) of the P. aeruginosa argF gene were identified by S1 mapping. The transcription initiation site for mRNA-1 was preceded by sequences having partial homology with the E. coli -35 and -10 consensus promoter sequences. No sequence similar to consensus promoters of enteric bacteria was found upstream of the 5' end of mRNA-2. E. coli carrying a P. aeruginosa argF+ recombinant plasmid produced mRNA-1 with low efficiency but no (or very little) mRNA-2. Arginine repressed argF transcription in P. aeruginosa. In the argF promoter region no sequence homologous to the "arg box" (arginine operator module) of E. coli was found. The mechanism of arginine repression in P. aeruginosa thus appears to be different from that in E. coli.
Paramodulation with Well-founded Orderings

For many years, all existing completeness results for Knuth–Bendix completion and ordered paramodulation required the term ordering ≻ to be well-founded, monotonic and total(izable) on ground terms. Then, it was shown that well-foundedness and the subterm property were enough for ensuring completeness of ordered paramodulation. Here we show that the subterm property is not necessary either. By using a new restricted form of rewriting, we obtain a completeness proof of ordered paramodulation for Horn clauses with equality, where well-foundedness of the ordering suffices. Apart from the theoretical significance of this result, some potential applications motivating the interest of dropping the subterm property are given. The proof of the results included in this article, being still technical in some parts, is pretty much shorter and easier to read than the one we have in the preliminary version of this work presented at the CADE, 2002 conference (Bofill, and Rubio, 2002, CADE, Vol. 2392 of LNAI, pp. 456–470).
Deep venous thrombosis with suspected pulmonary embolism: detection with combined CT venography and pulmonary angiography.

PURPOSE To determine the frequency and location of deep venous thrombosis at computed tomographic (CT) venography after CT pulmonary angiography in a large series of patients clinically suspected of having pulmonary embolism and to compare the accuracy of CT venography with lower-extremity venous sonography. MATERIALS AND METHODS Venous phase images were acquired from the diaphragm to the upper calves after completion of CT pulmonary angiography in 650 patients (373 women, 277 men; age range, 18-99 years; mean age, 63 years) to determine the presence and location of deep venous thrombosis. Results of CT venography were compared with those of bilateral lower-extremity venous sonography in 308 patients. RESULTS A total of 116 patients had pulmonary embolism and/or deep venous thrombosis, including 27 patients with pulmonary embolism alone, 31 patients with deep venous thrombosis alone, and 58 patients with both. Among 89 patients with deep venous thrombosis, thrombosis was bilateral in 26, involved the abdominal or pelvic veins in 11, and was isolated to the abdominal or pelvic veins in four. In patients in whom sonographic correlation was available, CT venography had a sensitivity of 97% and a specificity of 100% for femoropopliteal deep venous thrombosis. CONCLUSION Combined CT venography and pulmonary angiography can accurately depict the femoropopliteal deep veins, permitting concurrent testing for venous thrombosis and pulmonary embolism. CT venography also defines pelvic or abdominal thrombus, which was seen in 17% of patients with deep venous thrombosis.
Teacher Mobility and Financial Incentives

Extensive teacher mobility can undermine policy efforts to develop a high-quality workforce. In response, policymakers have increasingly championed financial incentives to retain teachers. In 2006, the Denver Public Schools adopted an alternative teacher compensation reform, the Professional Compensation System for Teachers (“ProComp”). Using longitudinal teacher-level data from 2001–2002 to 2010–2011, I estimate hazard models that identify the relationship between ProComp and teacher mobility. Specifically, I compare mobility patterns of teachers who received a ProComp incentive with those who did not, with special attention to teacher mobility in high-poverty schools. Results suggest receiving a ProComp incentive is associated with a significant decrease in the odds of departure. This appears to be driven by a decrease in a teacher’s odds of leaving the district rather than moving to a new school within the district, by voluntary ProComp participants and by teachers who receive incentives that total more than $5,000.
Human Resource Development in SMEs: A Systematic Review of the Literature

Human Resource Development (HRD) in small and medium-sized enterprises (SMEs) is a significant area of scholarship. However, the cumulativeness of research on HRD in SMEs remains relatively low when compared to HRD generally. This paper reports a systematic literature review (SLR) to synthesise research in this area. A disciplined screening process resulted in a final sample of 117 papers published in 31 journals from 1995 to 2014. The synthesis of these empirical and theoretical studies revealed that: (a) the literature utilises a narrow range of theoretical and conceptual perspectives; (b) HRD is being investigated across a variety of SME contexts, themes and units of analysis; (c) researchers define HRD in multiple ways and use a diverse set of measures of HRD activity; (d) there is significant potential for future research across the SME and HRD disciplines, SME settings and beyond existing theoretical perspectives. We offer suggestions for further advancing the development of this area of research in terms of theory, content and methodology.
Transplanted Organizations: The Transfer of Japanese Industrial Organization to the U.S.

Industrial sociology and organization theory suggest that it is difficult to transfer organizations from one environment to another and that organizations that are transferred will take on characteristics of the new environment. We hypothesize that the organization/environment relation works in both directions and that organizations have the resources to alter their environments in light of theirfunctional requirements. We explore these issues in light of recent debates over new models of production organization and interfirm production networks. Japanese automotive assembly plants and their suppliers in the United States provide an ideal case to explore such questions because they represent organizations that are being transferred from a supportive to a foreign environment. We find that these Japanese automotive transplants have effectively transferred both intraand interorganizational characteristics, e.g., team-based work organization and 'just-in-time" supplier relations to the United States. Thus, they have actively transformed their environments to suit their needs.
Work–home interference: How does it manifest itself from day to day?

Abstract Although work–home interference (WHI) refers to a process of negative interaction between the work and home domains, little attention has been paid to the actual processes involved in the within-person, day-to-day management of work and home. Therefore, this study investigated if, and how, a global report for the individual, of WHI (i.e., a general indicator of experienced WHI) is reflected in daily reports of WHI, in employees’ daily activity patterns in the work and home domain, and in their daily health and well-being. Effort-Recovery theory (Meijman & Mulder, 1998) provided the theoretical basis for this study. Data were collected among 120 academic staff members (62% male) who completed a general questionnaire, addressing global WHI as well as demographical information, and who also participated in a 5-day daily diary study. WHI was measured using the 8-item WHI subscale of the Survey Work–home Interaction Nijmegen (SWING), with an adapted version being used for the diary studies. Results showed that global WHI: (1) was positively related to daily WHI; (2) was positively related to the time spent daily on overtime work in the evening; (3) was negatively related to the time spent daily on low-effort activities; and (4) was positively related to daily fatigue and sleep complaints. We conclude that Effort-Recovery theory seems promising for the study of WHI, and that diary studies are valuable, as these provide detailed insight into what global reports of WHI actually signify from day to day.
El Ni�o Chaos: Overlapping of Resonances Between the Seasonal Cycle and the Pacific Ocean-Atmosphere Oscillator

The El Ni�o—Southern Oscillation (ENSO) cycle is modeled as a low-order chaotic process driven by the seasonal cycle. A simple model suggests that the equatorial Pacific ocean-atmosphere oscillator can go into nonlinear resonance with the seasonal cycle and that with strong enough coupling between the ocean and the atmosphere, the system may become chaotic as a result of irregular jumping of the ocean-atmosphere system among different nonlinear resonances. An analysis of a time series from an ENSO prediction model is consistent with the low-order chaos mechanism.
SRL in Online Cooperative Learning: implications for pre-service teacher training

The aim of this article is to investigate the relation between self-regulated learning and online collaborative environments. Based on the study of a blended course for trainee teachers, it explores the potential of the online collaborative component of the course for the practice and development of Self-Regulated Learning. The study made use of two questionnaires, developed within the TELEPEERS European project, to evaluate the potential support to SRL provided by technology-enhanced learning environments. The results provide information about the aspects of SRL practised in our environment. These include social competences, such as communication and negotiation with tutors and peers, emotional and motivational aspects, such as keeping up motivation and maintaining and restoring a positive working attitude, and cognitive and metacognitive skills such as management of time and learning environment and reflection on learning outcomes. The study also suggests the need to consider not only the SRL of the individuals involved in the learning process, but also the SRL of the whole community, that is, the result of the mediation between individual autonomy and group collaboration.
On the Security of an Efficient Group Key Agreement Scheme for MANETs

Yang et al. have proposed an efficient group key agreement scheme for Mobile Adhoc Networks. The scheme is efficient as only one bilinear computation is required for group members to obtain the session key. The scheme is analyzed for security without random oracle model. However, we prove that their scheme is not secure. In particular, we show that any passive adversary (or non-group member) can compute the session key without having access to the individual secret keys of the group members. Hence, Yang et al. scheme cannot be used for secure group communication. We also show that, the scheme cannot be used for secure group communication unless there exists a central entity, and hence cannot be used for secure communication in mobile adhoc networks.
Do Individual Response Styles Matter?: Assessing Differential Item Functioning for Men and Women in the NEO-PI-R

The occurrence of differential item functioning (DIF) for gender indicates that an instrument may not be functioning equivalently for men and women. Aside from DIF effects, item responses in personality questionnaires can also be influenced by response styles. This study analyzes the German NEO-PI-R regarding its differential item functioning for men and women while taking response styles into account. To this end, mixed Rasch models were estimated first to identify latent classes that differed in their response style. These latent classes were identified as extreme response style (ERS) and nonextreme response style (NERS). Then, DIF analyses were conducted separately for the different response styles and compared with DIF results for the complete sample. Several items especially on Neuroticism, Agreeableness, and Conscientiousness facets showed gender-DIF and thus function differentially between men and women. DIF results differed mainly in size between the complete sample and the response style subsampl.
Bayesian sparse representation for hyperspectral image super resolution

Despite the proven efficacy of hyperspectral imaging in many computer vision tasks, its widespread use is hindered by its low spatial resolution, resulting from hardware limitations. We propose a hyperspectral image super resolution approach that fuses a high resolution image with the low resolution hyperspectral image using non-parametric Bayesian sparse representation. The proposed approach first infers probability distributions for the material spectra in the scene and their proportions. The distributions are then used to compute sparse codes of the high resolution image. To that end, we propose a generic Bayesian sparse coding strategy to be used with Bayesian dictionaries learned with the Beta process. We theoretically analyze the proposed strategy for its accurate performance. The computed codes are used with the estimated scene spectra to construct the super resolution hyperspectral image. Exhaustive experiments on two public databases of ground based hyperspectral images and a remotely sensed image show that the proposed approach outperforms the existing state of the art.
Divergence in Signal Transduction Pathways of Platelet-derived Growth Factor (PDGF) and Epidermal Growth Factor (EGF) Receptors

Platelet-derived growth factor (PDGF) and serum, but not epidermal growth factor (EGF), stimulated sphingosine kinase activity in Swiss 3T3 fibroblasts and increased intracellular concentrations of sphingosine 1-phosphate (SPP), a sphingolipid second messenger (Olivera, A., and Spiegel, S. (1993) Nature 365, 557–560). We report herein thatdl-threo-dihydrosphingosine (DHS), a competitive inhibitor of sphingosine kinase that prevents PDGF-induced SPP formation, specifically inhibited the activation of two cyclin-dependent kinases (p34 cdc2 kinase and Cdk2 kinase) induced by PDGF, but not by EGF. SPP reversed the inhibitory effects of DHS on PDGF-stimulated cyclin-dependent kinases and DNA synthesis, demonstrating that the DHS effects were mediated via inhibition of sphingosine kinase. DHS also markedly reduced PDGF-stimulated but not EGF-stimulated mitogen-activated protein kinase activity and DNA binding activity of activator protein-1. Examination of the early signaling events of PDGF action revealed that DHS did not affect PDGF-induced autophosphorylation of the growth factor receptor or phosphorylation of the SH2/SH3 adaptor protein Shc and its association with Grb2. This sphingosine kinase inhibitor did not abrogate activation of phosphatidylinositol 3-kinase by PDGF. In agreement, treatment with SPP had no effect on these responses but did, however, potently stimulate phosphorylation of Crk, another SH2/SH3 adaptor protein. Moreover, DHS inhibited PDGF-stimulated, but not EGF-stimulated, Crk phosphorylation. Thus, regulation of sphingosine kinase activity defines divergence in signal transduction pathways of PDGF and EGF receptors leading to mitogen-activated protein kinase activation.
Conditioned Medium from Malignant Breast Cancer Cells Induces an EMT-Like Phenotype and an Altered N-Glycan Profile in Normal Epithelial MCF10A Cells

Epithelial-mesenchymal transition (EMT) is a key process in cancer development and progression. Communication (crosstalk) between cancer cells and normal (nonmalignant) cells may facilitate cancer progression. Conditioned medium (CM) obtained from cultured cancer cells contains secreted factors capable of affecting phenotypes and the behaviors of normal cells. In this study, a culture of normal breast epithelial MCF10A cells with CM from malignant breast cancer cells (termed 231-CM and 453-CM) resulted in an alteration of morphology. CM-treated MCF10A, in comparison with control cells, showed a reduced expression of the epithelial marker E-cadherin, increased expression of the mesenchymal markers fibronectin, vimentin, N-cadherin, and TWIST1, meanwhile cell proliferation and migration were enhanced while cell apoptosis was decreased. N-glycan profiles of 231-CM-treated and control MCF10A cells were compared by MALDI-TOF/TOF-MS (Matrix-Assisted Laser Desorption/ Ionization Time of Flight Mass Spectrometry) and a lectin microarray analysis. The treated cells showed lower levels of high-mannose-type N-glycan structures, and higher levels of complex-type and hybrid-type structures. Altered N-glycan profiles were also detected in 453-CM-treated and non-treated MCF10A cells by MALDI-TOF/TOF-MS, and we found that the expression of five fucosylated N-glycan structures (m/z 1406.663, 1590.471, 1668.782, 2421.141, and 2988.342) and one high-mannose structure m/z 1743.722 have the same pattern as 231-CM-treated MCF10A cells. Our findings, taken together, show that CM derived from breast cancer cells induced an EMT-like process in normal epithelial cells and altered their N-glycan profile.
Identification and Nearly Full-Length Genome Characterization of Novel Porcine Bocaviruses

The genus bocavirus includes bovine parvovirus (BPV), minute virus of canines (MVC), and a group of human bocaviruses (HBoV1-4). Using sequence-independent single primer amplification (SISPA), a novel bocavirus group was discovered with high prevalence (12.59%) in piglet stool samples. Two nearly full-length genome sequences were obtained, which were approximately 5,100 nucleotides in length. Multiple alignments revealed that they share 28.7–56.8% DNA sequence identity with other members of Parvovirinae. Phylogenetic analyses indicated their closest neighbors were members of the genus bocavirus. The new viruses had a putative non-structural NP1 protein, which was unique to bocaviruses. They were provisionally named porcine bocavirus 1 and 2 (PBoV1, PBoV2). PBoV1 and PBoV2 shared 94.2% nucleotide identity in NS1 gene sequence, suggesting that they represented two different bocavirus species. Two additional samples (6V, 7V) were amplified for 2,407 bp and 2,434 bp products, respectively, including a partial NP1 gene and the complete VP1 gene; Phylogenetic analysis indicated that 6Vand 7V grouped with PBoV1 and PBoV2 in the genus of bocavirus, but were in the separate clusters. Like other parvoviruses, PBoV1, PBoV2, 6Vand 7V also contained a putative secretory phospholipase A2 (sPLA2) motif in the VP1 unique region, with a conserved HDXXY motif in the catalytic center. The conserved motif YXGXF of the Ca2+-binding loop of sPLA2 identified in human bocavirus was also found in porcine bocavirus, which differs from the YXGXG motif carried by most other parvoviruses. The observation of PBoV and potentially other new bocavirus genus members may aid in molecular and functional characterization of the genus bocavirus.
Age and gender patterns of sport involvement among the Swiss labor force.

Under the influence of the Sport for All movement the sport system in Switzerland has changed. Sport has become a leisure-time activity for an increasing number of people and has gained new meanings and forms. Many traditional limitations to participation appear to have been removed. By focusing on gender and age, this study, based on a survey of 1,103 employees, explores the extent to which particularisms and inequalities in contemporary recreational Swiss sport still exist. Although the involvement in sport by men and women, and involvement of different age groups, are quite similar in terms of frequency, their forms and meanings remain different. Using correspondence analysis we identify different sports fields and different sporting patterns by gender and age in terms of motives, places, and activities.
Locus of control and the flow experience: An experimental analysis

The present research addresses the notion that the compatibility of skills and task demands involved in a given activity elicits a flow experience that renders the respective activity rewarding. The study employed an experimental paradigm to document the causal impact of skills–demands compatibility on the emergence of flow and revealed that participants characterized by a strong internal locus of control (LOC) were most sensitive to the manipulation of skills–demands compatibility and experienced flow under conditions of a fit of skills and task demands, whereas individuals with a weak internal LOC did not enter the state of flow. In line with previous findings, this suggests that distinct personality attributes are of critical relevance for the experience of flow to emerge. Copyright © 2008 John Wiley & Sons, Ltd.
Full-Duplex Multi-Antenna Relay Assisted Cooperative Non-Orthogonal Multiple Access

We consider a cooperative non-orthogonal multiple access (NOMA) network in which a full-duplex (FD) multi-antenna relay assists transmission from a base station (BS) to a set of far users with poor channel conditions, while at the same time the BS transmits to a set of near users with strong channel conditions. We assume imperfect self- interference (SI) cancellation at the FD relay and imperfect inter-user interference cancellation at the near users. In order to cancel the SI at the relay a zero-forcing based beamforming scheme is used and the corresponding outage probability analysis of two user selection strategies, namely random near user and random far user (RNRF), and nearest near user and nearest far user (NNNF), are derived. Our finding suggests that significant performance improvement can be achieved by using the FD multi- antenna relay compared to the counterpart system with a half-duplex relay. The achieved performance gain depends on network parameters such as the user density, user zones, path loss and the strength of the inter-user interference in case of near users. We also show that the NNNF strategy exhibits a superior outage performance compared to the RNRF strategy, especially in the case of near user.
Forging a Link Between Conduct Disorder and Adolescent/Adult Offending Via Externalizing Behavior and Reading Performance

The current study tested whether teacher-rated externalizing behavior and academic (reading) performance mediate the relationship between childhood onset conduct disorder and self-reported adolescent delinquency and officially recorded adult offending. All 411 boys from the Cambridge Study of Delinquent Development served as participants in this study. Mediation analysis revealed that the direct effect of childhood onset conduct disorder and the indirect effect of reading performance on mid-adolescent delinquency and early adult offending were nonsignificant, but that adolescent externalizing behavior had a significant indirect effect on both delinquency and adult offending.