Miracle-dz/UniFAR-FTUs huggingface dataset:
Depression Treatment Among Elderly Medicare Beneficiaries With Incident Cases of Cancer and Newly Diagnosed Depression.

OBJECTIVE Depression treatment can improve the health outcomes of elderly cancer survivors. There is a paucity of studies on the extent to which depression is treated among elderly cancer survivors. Therefore, this study estimated the rates of depression treatment among elderly cancer survivors and identified the factors affecting depression treatment. METHODS A retrospective cohort study design was adopted, and data were obtained from the linked Surveillance, Epidemiology and End Results (SEER) and Medicare database. Elderly individuals (≥ 66 years) with incident cases of breast, colorectal, or prostate cancer and newly diagnosed depression (N=1,673) were followed for six months after the depression diagnosis to identify depression treatment (antidepressants only, psychotherapy only, combined treatment with both antidepressants and psychotherapy, and no depression treatment). Chi-square tests and multinomial logistic regressions were used to analyze the factors associated with depression treatment. RESULTS In this study population, 46% received antidepressants only, 27% received no treatment, 18% received combined therapy, and 9% received psychotherapy only. Factors associated with depression treatment included anxiety, the percentage of psychologists at the county level, the number of visits to primary care physicians, ongoing cancer treatment, the presence of other chronic conditions, and race-ethnicity. CONCLUSIONS The study findings indicate that two-thirds of cancer survivors received depression treatment in the first six months after depression diagnosis. Our study findings indicate that racial-ethnic disparities in depression treatment persist and competing demands for cancer treatment may take priority over depression care. Also, the availability of psychologists may influence receipt of psychotherapy among cancer survivors.
Dietary exposure to non-dioxin-like PCBs of the Hong Kong adult population from a total diet study

ABSTRACT Dietary exposure of Hong Kong adults to the sum of the six indicator PCBs (Σ6 PCBs; PCB 28, 52, 101, 138, 153, and 180) was estimated in this study using the Total Diet Study (TDS) approach. Seventy one commonly-consumed food items of animal origin were sampled in four seasons and prepared as consumed in 2010–2011. The results showed that the main dietary source of Σ6 PCBs to the adult population was ‘fish, seafood and their products’ which accounted for 84.3% of the total exposure. About 50% of the total exposure was contributed by four fish species: salmon (cooked salmon and salmon sashimi, 19.9%), mandarin fish (14.7%), pomfret fish (8.5%) and yellow croaker (7.5%). Salmon was found to contain the highest mean level of Σ6 PCBs of 5.7 ng g−1 fresh weight at upper bound estimation, ranging from 4.4 to 6.3 ng g−1. The lower bound and upper bound exposure estimates of Ʃ6 PCBs to the average consumer of the population were found to be 0.68 and 1.38 ng kg−1 body weight day−1 respectively while for high consumers, the lower bound and upper bound exposure estimates were 3.08 and 3.84 ng kg−1 body weight day−1 respectively. In addition, the dietary exposures to individual indicator PCB congeners were also estimated.
[Analysis of withdrawal from noninvasive mechanical ventilation in patients with obesity-hypoventilation syndrome. Medium term results].

OBJECTIVE To evaluate the possibility of cessation of noninvasive mechanical ventilation or noninvasive positive pressure ventilation (NPPV) treatment in patients with obesity-hypoventilation syndrome (OHS). MATERIAL AND METHODS A study was carried out on 22 OHS patients who had received NPPV for a minimum of 1 year. Prior to evaluation of the cessation of ventilatory support, all patients underwent the following tests: diurnal and nocturnal arterial blood gases, nocturnal oximetry, nocturnal cardiorespiratory polygraphy, and lung function tests. Based on the results obtained, 12 patients who met the NPPV cessation criteria were selected. This group was liberated from ventilatory support for 3 months. At the end of this period, all of the tests initially carried out were repeated on all patients and the results were compared with those obtained at the time of NPPV cessation. RESULTS Three months after liberation from NPPV, no significant variations were observed in arterial blood gases or in lung function tests in comparison with the values found at the time of cessation. In terms of individual development, only 1 patient showed blood gas deterioration requiring a return to NPPV. In 7 cases, a polygraph showed obstructive sleep apnea syndrome (OSAS), 4 at the time of cessation and 3 at the follow-up examination carried out at the end of the 3 months. Finally, in 4 patients the respiratory situation remained stable, with no significant variations in the tests done before or after cessation of NPPV. CONCLUSIONS The majority of the OHS patients who receive prolonged treatment with NPPV continue to be stable 3 months after liberation from ventilatory support. A high percentage of these patients can be seen to have OSAS once the hypercapnia situation is corrected.
The Humble Leader: Association of Discrepancies in Leader and Follower Ratings of Implementation Leadership With Organizational Climate in Mental Health.

OBJECTIVES Discrepancies, or perceptual distance, between leaders' self-ratings and followers' ratings of the leader are common but usually go unrecognized. Research on discrepancies is limited, but there is evidence that discrepancies are associated with organizational context. This study examined the association of leader-follower discrepancies in Implementation Leadership Scale (ILS) ratings of mental health clinic leaders and the association of those discrepancies with organizational climate for involvement and performance feedback. Both involvement and performance feedback are important for evidence-based practice (EBP) implementation in mental health. METHODS A total of 593 individuals-supervisors (leaders, N=80) and clinical service providers (followers, N=513)-completed surveys that included ratings of implementation leadership and organizational climate. Polynomial regression and response surface analyses were conducted to examine the associations of discrepancies in leader-follower ILS ratings with organizational involvement climate and performance feedback climate, aspects of climate likely to support EBP implementation. RESULTS Both involvement climate and performance feedback climate were highest where leaders rated themselves low on the ILS and their followers rated those leaders high on the ILS ("humble leaders"). CONCLUSIONS Teams with "humble leaders" showed more positive organizational climate for involvement and for performance feedback, contextual factors important during EBP implementation and sustainment. Discrepancy in leader and follower ratings of implementation leadership should be a consideration in understanding and improving leadership and organizational climate for mental health services and for EBP implementation and sustainment in mental health and other allied health settings.
Aberrant Frontoparietal Function during Recognition Memory in Schizophrenia: A Multimodal Neuroimaging Investigation

Prefrontal–parietal networks are essential to many cognitive processes, including the ability to differentiate new from previously presented items. As patients with schizophrenia exhibit structural abnormalities in these areas along with well documented decrements in recognition memory, we hypothesized that these patients would demonstrate memory-related abnormalities in prefrontal and parietal physiology as measured by both functional magnetic resonance imaging and magnetoencephalography (MEG). Medicated outpatients with schizophrenia (n = 18) and age-matched healthy control subjects (n = 18) performed an old–new recognition memory task while physiological data were obtained. Whereas controls exhibited strong, bilateral activation of prefrontal and posterior parietal regions during successful identification of old versus new items, patients exhibited greatly attenuated activation of the right prefrontal and parietal cortices. However, within the patient group, there was strong correlation between memory performance and activation of these right-sided regions as well as a tight correlation between old–new effect-related activations in frontal and parietal regions, a pattern not seen in control subjects. Using MEG, control subjects—but not patients—exhibited a sequential pattern of old > new activity in the left posterior parietal cortex and then right prefrontal cortex; however, patients uniquely exhibited old > new activity in right temporal cortex. Collectively, these findings point to markedly different distributions of regional specialization necessary to complete the old–new item recognition task in patients versus controls. Inefficient utilization of prefrontal–parietal networks, with compensatory activation in temporal regions, may thus contribute to deficient old–new item recognition in schizophrenia.
Taxonomies of psychological individual differences: biological perspectives on millennia-long challenges

This Editorial highlights a unique focus of this theme issue on the biological perspectives in deriving psychological taxonomies coming from neurochemistry, neuroanatomy, neurophysiology, genetics, psychiatry, developmental and comparative psychology—as contrasted to more common discussions of socio-cultural concepts (personality) and methods (lexical approach). It points out the importance of the distinction between temperament and personality for studies in human and animal differential psychophysiology, psychiatry and psycho-pharmacology, sport and animal practices during the past century. It also highlights the inability of common statistical methods to handle nonlinear, feedback, contingent, dynamical and multi-level relationships between psychophysiological systems of consistent psychological traits discussed in this theme issue. This article is part of the theme issue ‘Diverse perspectives on diversity: multi-disciplinary approaches to taxonomies of individual differences'.
Clustering patterns of oral and general health‐risk behaviours in Brazilian adolescents: Findings from a national survey

OBJECTIVES To evaluate how oral and general health-risk behaviours cluster among Brazilian adolescents. METHODS The study comprised a total of 109 104 adolescents (52.2% female) participating in the Brazilian National School-based Student Health Survey (PeNSE). Seventeen behaviours (including diet; oral and hand hygiene; frequency of dental visits; tobacco, alcohol and drug use; sexual behaviour; physical activity, and risk for external causes) were measured using a self-reported questionnaire. Pairwise correlations between the health-risk behaviours were performed, and clustering was assessed by the hierarchical agglomerative cluster analysis (HACA), which was used to identify stable cluster solutions of the health-risk behaviours. RESULTS All health-risk behaviours were correlated with at least 1 behaviour (P < .01). HACA indicated 2 broad stable clusters (n = 105 604). The first cluster included current smoking, illegal drug use, no hand washing before meals, unprotected sex, no helmet use, less frequent toothbrushing, no seatbelt use, physical fighting, skipping breakfast, current drinking, high sugar intake and, at the final stage, no dental visits. The second cluster included insufficient physical activity, eating while watching TV or studying, and low fruit intake. CONCLUSIONS The health-risk behaviours clustered into 2 specific patterns among Brazilian adolescents. One cluster gathered a combination of lack of adherence to preventive behaviours and the undertaking of risky conduct, while the second reflected an unhealthy lifestyle (sedentary habits and low fruit diet). Knowledge about the clustering patterns of oral and general health behaviours in adolescents can better direct the integration of oral and general health promotion interventions.
Case Studies of Teacher Effectiveness in Second Grade Physical Education

The purpose of this study was to describe the teaching behaviors of four teachers who had varying degrees of expertise in working with second grade students and to improve the teachers’ effectiveness. Four experienced teachers were asked to teach a six-lesson unit in jumping and landing skills to an intact class of their choice. Students were pre- and posttested on their ability to produce and reduce force using a force platform and a jump for distance without the platform. OSCD-PE (Rink, 1979) was used to describe the more general aspects of the teachers’ content development and managerial skills. Task presentation, nature of feedback, and appropriateness of student responses were obtained using the QMTPS (Rink & Werner, 1989). Additional information was obtained by counting practice trials and analyzing teacher written plans and approaches to content. Following the first teaching experience, the researchers gave feedback to the teachers and asked them to reteach the unit to a different class. Product an.
Text Messaging and Mobile Phone Apps as Interventions to Improve Adherence in Adolescents With Chronic Health Conditions: A Systematic Review

Background The number of adolescents with chronic health conditions (CHCs) continues to increase. Medication nonadherence is a global challenge among adolescents across chronic conditions and is associated with poor health outcomes. While there has been growing interest in the use of mHealth technology to improve medication adherence among adolescents with CHCs, particularly text messaging and mobile phone apps, there has been no prior systematic review of their efficacy. Objective The purpose of this review was to systematically evaluate the most recent evidence for the efficacy of text messaging and mobile phone apps as interventions to promote medication adherence among adolescents with CHCs. Methods PubMed, Embase, CENTRAL, PsycINFO, Web of Science, Google Scholar, and additional databases were searched from 1995 until November 2015. An additional hand search of related themes in the Journal of Medical Internet Research was also conducted. The Preferred Reporting Results of Systematic Reviews and Meta-Analyses guidelines were followed. Two reviewers independently screened titles/abstracts, assessed full-text articles, extracted data from included articles, and assessed their quality using Grades of Recommendation, Assessment, Development, and Evaluation criteria. Included studies were described in original research articles that targeted adherence in adolescents with CHCs (12-24 years-old). Results Of the 1423 records examined, 15 met predefined criteria: text messaging (n=12) and mobile phone apps (n=3). Most studies were performed in the United States (11/15, 73%), were randomized-controlled trials (8/15, 53%), had a sample size <50 (11/15, 73%), and included adherence self-report and/or biomarkers (9/15, 60%). Only four studies were designed based on a theoretical framework. Approaches for text messaging and mobile phone app interventions varied across studies. Seven articles (7/15, 47%) reported significant improvement in adherence with moderate to large standardized mean differences. Most of the included studies were of low or moderate quality. Studies varied in sample size, methods of adherence assessment, and definition of adherence, which prohibited performing a meta-analysis. Conclusions The use of text messaging and mobile phone app interventions to improve medication adherence among adolescents with CHCs has shown promising feasibility and acceptability, and there is modest evidence to support the efficacy of these interventions. Further evaluation of short- and long-term efficacy and cost-effectiveness of these interventions is warranted given the early and evolving state of the science.
Optimal deployment of large wireless sensor networks

A spatially distributed set of sources is creating data that must be delivered to a spatially distributed set of sinks. A network of wireless nodes is responsible for sensing the data at the sources, transporting them over a wireless channel, and delivering them to the sinks. The problem is to find the optimal placement of nodes, so that a minimum number of them is needed. The critical assumption is made that the network is massively dense, i.e., there are so many sources, sinks, and wireless nodes, that it does not make sense to discuss in terms of microscopic parameters, such as their individual placements, but rather in terms of macroscopic parameters, such as their spatial densities. Assuming a particular interference-limited, capacity-achieving physical layer, and specifying that nodes only need to transport the data (and not to sense them at the sources, or deliver them at the sinks once their location is reached), the optimal node placement induces a traffic flow that is identical to the electrostatic field created if the sources and sinks are replaced by a corresponding distribution of positive and negative charges. Assuming a general model for the physical layer, and specifying that nodes must not only transport the data, but also sense them at the sources and deliver them at the sinks, the optimal placement of nodes is given by a scalar nonlinear partial differential equation found by calculus of variations techniques. The proposed formulation and derived equations can help in the design of large wireless sensor networks that are deployed in the most efficient manner, not only avoiding the formation of bottlenecks, but also striking the optimal balance between reducing congestion and having the data packets follow short routes.
Rod-through-plate fixator in the treatment of long bone fractures of small animals

This study is part of a larger project for finding optimal methods for fracture fixation of tubular bones in small animals. Strong fracture fixation is important in animals to ensure early weight bearing and quick fracture healing. In this study, plate fixation was used to treat experimental tibial fractures of sheep. Radiographical, histological and immunohistochemical methods were used for evaluation of the healing process. Plate fixation gives good stability for the healing process but traumatisation of soft tissues during the operation is quite extensive. The regeneration process is also slow and, therefore, this method cannot be considered as most appropriate for treatment of fractures of long tubular bones in small animals.
Classical Structured Prediction Losses for Sequence to Sequence Learning

There has been much recent work on training neural attention models at the sequence-level using either reinforcement learning-style methods or by optimizing the beam. In this paper, we survey a range of classical objective functions that have been widely used to train linear models for structured prediction and apply them to neural sequence to sequence models. Our experiments show that these losses can perform surprisingly well by slightly outperforming beam search optimization in a like for like setup. We also report new state of the art results on both IWSLT’14 German-English translation as well as Gigaword abstractive summarization. On the large WMT’14 English-French task, sequence-level training achieves 41.5 BLEU which is on par with the state of the art.
Oncogenic RAS-induced downregulation of ATG12 is required for survival of malignant intestinal epithelial cells

ABSTRACT Activating mutations of RAS GTPase contribute to the progression of many cancers, including colorectal carcinoma. So far, attempts to develop treatments of mutant RAS-carrying cancers have been unsuccessful due to insufficient understanding of the salient mechanisms of RAS signaling. We found that RAS downregulates the protein ATG12 in colon cancer cells. ATG12 is a mediator of autophagy, a process of degradation and reutilization of cellular components. In addition, ATG12 can kill cells via autophagy-independent mechanisms. We established that RAS reduces ATG12 levels in cancer cells by accelerating its proteasomal degradation. We further observed that RAS-dependent ATG12 loss in these cells is mediated by protein kinases MAP2K/MEK and MAPK1/ERK2-MAPK3/ERK1, known effectors of RAS. We also demonstrated that the reversal of the effect of RAS on ATG12 achieved by the expression of exogenous ATG12 in cancer cells triggers both apoptotic and nonapoptotic signals and efficiently kills the cells. ATG12 is known to promote autophagy by forming covalent complexes with other autophagy mediators, such as ATG5. We found that the ability of ATG12 to kill oncogenic RAS-carrying malignant cells does not require covalent binding of ATG12 to other proteins. In summary, we have identified a novel mechanism by which oncogenic RAS promotes survival of malignant intestinal epithelial cells. This mechanism is driven by RAS-dependent loss of ATG12 in these cells.
Indigenous identity transformations: The pivotal role of student-to-student abuse in Indian Residential Schools

Embracing a shared social identity typically serves to protect group members in the face of threats. However, under some conditions, intragroup dynamics are diverted so that instead, they contribute to disturbances in collective well-being. The present analysis applies a social identity framework to understand how intragroup processes elicited in Indian Residential Schools (IRS) altered the capacity of Indigenous peoples to overcome damage to their identity and collective functioning. With the alleged goal of assimilating the Indigenous population, residential schools in Canada entailed the forced removal of Indigenous children from their communities. A Truth and Reconciliation Commission established in 2008 confirmed the extensive abuse perpetrated by IRS staff, but also raised awareness of the pervasiveness of student-to-student abuse. Supported by qualitative analyses of the reports of social service providers working with IRS survivors (N = 43), it is argued that a key part of the dynamics in the IRSs was the subversion of intragroup processes among Indigenous children in attendance. Understanding intragroup dynamics provides a basis for recognizing the persistent effects of IRSs, and for identifying strategies to heal and reclaim a positive collective identity.