Miracle-dz/UniFAR-FTUs huggingface dataset:
Latin Journey: Cuban and Mexican Immigrants in the United States.

This in-depth study of the migration process is primarily concerned with recent Cuban and Mexican immigration into the United States. A theoretical overview of labor migration and a historical survey of immigration to the United States from 1890 to 1979 are first presented. The political and socioeconomic circumstances confronting the Mexicans and the Cubans in their home countries prior to migration are contrasted. Information is presented concerning place of residence social adaptation labor market participation and income for the two immigrant groups. These data are from interviews conducted at the time of the immigrants arrival in 1973 again in 1976 and finally in 1979. Detailed empirical findings are presented in 111 tables and an appendix. Particular attention is given to the Cuban enclave in Miami the economic and occupational mobility of Mexican immigrants immigrants perceptions of the United States and the social relationships of immigrants. Finally the theoretical and practical implications of the major trends observed in this study are summarized.
The perils of dating your boss

Engaging in romantic relationships at work, especially with one’s superiors (i.e., hierarchical workplace romance; [HWR]), has generally been shown to negatively impact the participants involved. However, less attention has focused on its impact on the career advancement of lower status romance participants and when such an impact is exacerbated. Two experiments show that third-party evaluators were less likely to promote (Study 1) and select lower status HWR participants for training opportunities (Study 2) than their counterparts not in an HWR. Moreover, the negative career ramification of an HWR was stronger for men romantically involved with their female superiors than women with their male superiors (Study 2). This research highlights the need for organizational members to be aware of biases associated with HWR and gender role–based status expectations because past achievements may be discounted for lower status HWR participants, especially men.
Prognostic Value of Cardiopulmonary Exercise Testing in Heart Failure With Reduced, Midrange, and Preserved Ejection Fraction

Background This study aimed to compare the independent and incremental prognostic value of peak oxygen consumption (VO 2) and minute ventilation/carbon dioxide production (VE/VCO 2) in heart failure (HF) with preserved (HFpEF), midrange (HFmEF), and reduced (HFrEF) ejection fraction (LVEF). Methods and Results In 195 HFpEF (LVEF ≥50%), 144 HFmEF (LVEF 40–49%), and 630 HFrEF (LVEF <40%) patients, we assessed the association of cardiopulmonary exercise testing variables with the composite outcome of death, left ventricular assist device implantation, or heart transplantation (256 events; median follow‐up of 4.2 years), and 2‐year incident HF hospitalization (244 events). In multivariable Cox regression analysis, greater association with outcomes in HFpEF than HFrEF were noted with peak VO 2 (HR [95% confidence interval]: 0.76 [0.67–0.87] versus 0.87 [0.83–0.90] for the composite outcome, P interaction=0.052; 0.77 [0.69–0.86] versus 0.92 [0.88–0.95], respectively for HF hospitalization, P interaction=0.003) and VE/VCO 2 slope (1.11 [1.06–1.17] versus 1.04 [1.03–1.06], respectively for the composite outcome, P interaction=0.012; 1.10 [1.05–1.15] versus 1.04 [1.03–1.06], respectively for HF hospitalization, P interaction=0.019). In HFmEF, peak VO 2 and VE/VCO 2 slope were associated with the composite outcome (0.79 [0.70–0.90] and 1.12 [1.05–1.19], respectively), while only peak VO 2 was related to HF hospitalization (0.81 [0.72–0.92]). In HFpEF and HFrEF, peak VO 2 and VE/VCO 2 slope provided incremental prognostic value beyond clinical variables based on the C‐statistic, net reclassification improvement, and integrated diagnostic improvement, with models containing both measures demonstrating the greatest incremental value. Conclusions Both peak VO 2 and VE/VCO 2 slope provided incremental value beyond clinical characteristics and LVEF for predicting outcomes in HFpEF. Cardiopulmonary exercise testing variables provided greater risk discrimination in HFpEF than HFrEF.
Induction of reactive oxygen species in chlamydomonas reinhardtii in response to contrasting trace metal exposures

The toxicity of metals to organisms is, in‐part, related to the formation of reactive oxygen species (ROS) in cells and subsequent oxidative stress. ROS are by‐products of normal respiration and photosynthesis processes in organisms, but environmental factors, like metal exposure, can stimulate excess production. Metals involved in several different mechanisms such as Haber‐Weiss cycling and Fenton‐type reactions can produce ROS. Some metals, such as Cd, may contribute to oxidative stress indirectly by depleting cellular antioxidants. We investigated the measurement of ROS as a sensitive biomarker of metal toxicity (that could possibly be implemented in a biotic ligand model for algae) and we compared ROS induction in response to several contrasting transition metals (Cu, V, Ni, Zn, and Cd). We also compared the ROS response to glutathione and growth toxicity endpoints measured in a previous study. The cell‐permeable dye, 2′7′dichlorodihydrofluorescein diacetate, was used as a probe to detect formation of ROS in Chlamydomonas reinhardtii cells. Metal‐exposed cells were incubated with the fluorescent dye in a 96‐well plate and monitored over 5.5 h. A dose‐response of ROS formation was observed with Cu exposure in the range of 20–500 nM. Cu produced more ROS compared with either Zn or Cd (both nonredox active metals). The redox‐active metal V produced increased ROS with increased concentration. The measurement of ROS may be a useful indicator of Cu toxicity, but the signal to noise ratio was better for the glutathione endpoint assay. © 2011 Wiley Periodicals, Inc. Environ Toxicol 28: 516–523, 2013.
Role of plasmacytoid dendritic cells in breast cancer bone dissemination

Elevated levels of plasmacytoid dendritic cells (pDC) have been observed as breast cancer disseminates to the bone. The selective depletion of pDC in mice led to a total abrogation of bone metastasis as well as to an increase in TH1 antitumor response, suggesting that pDC may be considered as a potential therapeutic target for metastatic breast cancer.
Structural, Biochemical, and Biophysical Characterization of Idelalisib Binding to Phosphoinositide 3-Kinase δ*

Background: Idelalisib is a PI3Kδ inhibitor used to treat hematological malignancies. Results: Idelalisib is selective, noncovalent, reversible, and ATP-competitive. Conclusion: The crystal structure helps explain the potency and selectivity of idelalisib. The biophysical and biochemical data clarify the details of the inhibitor's interactions with PI3Kδ. Significance: Its use in humans makes it important to understand how idelalisib inhibits PI3Kδ. Idelalisib (also known as GS-1101, CAL-101, IC489666, and Zydelig) is a PI3Kδ inhibitor that has recently been approved for the treatment of several hematological malignancies. Given its use in human diseases, we needed a clear picture of how idelalisib binds to and inhibits PI3Kδ. Our data show that idelalisib is a potent and selective inhibitor of the kinase activity of PI3Kδ. A kinetic characterization clearly demonstrated ATP-competitive inhibition, and several additional biochemical and biophysical assays showed that the compound binds reversibly and noncovalently to the kinase. A crystal structure of idelalisib bound to the p110δ subunit of PI3Kδ furthers our understanding of the binding interactions that confer the potency and selectivity of idelalisib.
Preventive Effects of Exenatide on Endothelial Dysfunction Induced by Ischemia-Reperfusion Injury via KATP Channels

Objective—The purpose of this study was to evaluate whether exenatide administration can prevent impairment in endothelium-dependent vasodilatation induced by ischemia-reperfusion (IR) injury and whether this effect is mediated by KATP channel opening. Methods and Results—In a double-blind, placebo-controlled, crossover design, 20 volunteers were randomly assigned to 2 groups: subcutaneous exenatide (10 &mgr;g) or placebo administration. At 30 minutes after the study drug administration, endothelium-dependent flow-mediated dilatation (FMD) of the radial artery was measured before and after IR (15 minutes of ischemia at the level of the brachial artery followed by 15 minutes of reperfusion) injury. Seven days later, both groups were crossed over and received the other treatment (ie, placebo or exenatide) and underwent the same protocol. Pre-IR radial artery diameter, FMD, and baseline radial artery diameter after IR injury were similar between 2 groups (P=no significant difference). After placebo administration, IR significantly blunted FMD (before IR: 12.0±6.23%; after IR: 4.6±3.57%, P=0.02). Exenatide prevented this impairment (FMD before IR: 15.0±7.14%; FMD after IR: 15.0±5.96%, P=no significant difference; P<0.001 compared with placebo). In a separate protocol, this protective effect was completely abolished by pretreatment with glibenclamide (glyburide, 5 mg), a blocker of KATP channels (n=7; FMD before IR: 12.0±2.2%; after IR: 3.2±2.1%, P<0.001). Conclusion—The present study demonstrates that subcutaneous exenatide protects IR-induced endothelial dysfunction through opening of KATP channels in human IR injury model.
The manifestations of perfectionistic self-presentation in a clinical sample

Perfectionism has long been recognized as an important personality trait that has a significant impact on emotional and social well-being. More recently, it has been recognized that there is a stylistic aspect to perfectionism that focuses on a desire to appear perfect. This perfectionistic self-presentation, and in particular, the desire for concealment of imperfections, has been related to psychopathology in past research. However, it is proposed that perfectionistic selfpresentation presents a particular concern from a clinical perspective because of it's indirect effects on pathology; a desire to conceal imperfections is especially problematic to the extent that it impacts the experience of therapy and the therapy relationship. The current study examined the cognitive, affective/physiological, and behavioral manifestations of perfectionistic selfpresentation in a clinical sample. Ninety clinical subjects completed self-report measures of perfectionistic self-presentation, trait perfectionism, impression management, mood, appraisals, and self-handicapping. A brief structured assessment interview that included a discussion of past mistakes, was conducted by trained clinical interviewers. Physiological monitors recorded heart rate and skin conductance level throughout the interview, and the interview was videotaped. Post-interview measures of mood, appraisals, and self-handicapping, were also completed. Results at the bivariate level showed that the self-protective dimensions of perfectionistic selfpresentation were associated with more distress both prior to and following the interview, higher heart rate and greater change in heart rate when discussing mistakes (and greater skin conductance for men), greater claims of disability from self-handicaps, and appraisals of the interviewer as both threatening (wanting more than the participant could provide) and disappointed following the interview. Regression analyses showed that the desire to avoid disclosing imperfections was a unique predictor of appraisals of threat over and above demographics, trait perfectionism, and other measures of distress (interaction anxiety and
The Manchester Driver Behaviour Questionnaire as a predictor of road traffic accidents

The Driver Behaviour Questionnaire (DBQ) has mainly been used as a predictor of self-reported road traffic accidents. The associations between crashes and the violation and error factors of the DBQ, however, may be spuriously high due to reporting bias. In the present study, the DBQ was tested as a predictor of self-reported and recorded accidents in four samples of private and professional drivers. The findings show that the DBQ scale only predicts self-reported accidents, not recorded crashes, despite the higher validity of company data and the higher means of the recorded data across these samples. The results can be explained by a common method variance bias. In a review of the DBQ research, the use of the instrument was found to be heterogeneous concerning the number of items, scales used and factor analytic methods applied. Thus, the DBQ may not be as homogeneous and as successful in predicting accidents as is often claimed.
THE THEORY OF MORAL SENTIMENTS

Book file PDF easily for everyone and every device. You can download and read online The Theory of Moral Sentiments file PDF Book only if you are registered here. And also you can download or read online all Book PDF file that related with The Theory of Moral Sentiments book. Happy reading The Theory of Moral Sentiments Bookeveryone. Download file Free Book PDF The Theory of Moral Sentiments at Complete PDF Library. This Book have some digital formats such us :paperbook, ebook, kindle, epub, fb2 and another formats. Here is The Complete PDF Book Library. It's free to register here to get Book file PDF The Theory of Moral Sentiments.
Does Wikipedia Information Help Netflix Predictions?

We explore several ways to estimate movie similarity from the free encyclopedia Wikipedia with the goal of improving our predictions for the Netflix Prize. Our system first uses the content and hyperlink structure of Wikipedia articles to identify similarities between movies. We then predict a user's unknown ratings by using these similarities in conjunction with the user's known ratings to initialize matrix factorization and k-Nearest Neighbours algorithms. We blend these results with existing ratings-based predictors. Finally, we discuss our empirical results, which suggest that external Wikipedia data does not significantly improve the overall prediction accuracy.
Manipulation of Plant Host Susceptibility: An Emerging Role for Viral Movement Proteins?

Viruses encode viral suppressors of RNA silencing (VSRs) to counteract RNA silencing, a major antiviral defense response in plants. Recent studies indicate a role of virus-derived siRNAs in manipulating the expression of specific host genes and that certain plant viral movement proteins (MPs) can act as viral enhancers of RNA silencing (VERs) by stimulating the spread of silencing between cells. This suggests that viruses have evolved complex responses capable to efficiently hijack the host RNA silencing machinery to their own advantage. We draw here a dynamic model of the interaction of plant viruses with the silencing machinery during invasion of the host. The model proposes that cells at the spreading front of infection, where infection starts from zero and the VSR levels are supposedly low, represent potential sites for viral manipulation of host gene expression by using virus- and host-derived small RNAs. Viral MPs may facilitate the spread of silencing to produce a wave of small RNA-mediated gene expression changes ahead of the infection to increase host susceptibility. When experimentally ascertained, this hypothetical model will call for re-defining viral movement and the function of viral MPs.
Adverse effect of diabetes and hyperglycaemia on arterial stiffness in Europeans, South Asians, and African Caribbeans in the SABRE study

Objectives: Ethnic minority groups in the UK experience marked differences in cardiovascular disease risk. We investigated differences in arterial central haemodynamics, stiffness, and load in a tri-ethnic population-based cohort. Methods: A total of 1312 participants (70 ± 6 years) underwent echocardiography and measurement of brachial and central blood pressure to assess central arterial haemodynamics including central pulse pressure (cPP), arterial stiffness [cPP/stroke volume (SV)], systemic vascular resistance (SVR), and load (Ea). Results: Brachial and central SBPs were similar in all ethnic groups. Compared with Europeans, cPP, cPP/SV, and Ea were higher in South Asians. In contrast, cPP/SV was lower in African Caribbeans despite higher mean arterial pressure, higher SVR, and higher diabetes prevalence. cPP/SV and Ea remained significantly higher in South Asians and significantly lower in African Caribbeans after multivariate adjustment. Diabetes and higher HbA1c were more strongly associated with higher cPP/SV in South Asians than in Europeans (Pinteraction = 0.045 and 0.005, respectively); higher HbA1c was also more strongly associated with increased Ea in South Asians than Europeans (Pinteraction = 0.01). There was no evidence of an interaction between glycaemia and cPP/SV in African Caribbeans. Conclusions: Compared with Europeans, South Asians have unfavorable arterial function. Diabetes and hyperglycaemia have a more deleterious effect on cPP/SV and Ea in South Asians. In contrast, African Caribbeans have more favourable arterial function than Europeans and South Asians. These differences may contribute to the differential ethnic rates of cardiovascular disease.
GAST, a Genomic Alignment Search Tool

Alignment to a genomic sequence is a common task in modern bioinformatics. By improving the methods used, significant amount of time and resources can be saved. We have developed a new genomic alignment search tool, called GAST, for sequences of at least 160 nt. GAST is many times faster than commonly used alignment tools BLAT and Mega BLAST. As the sizes of query sequences and the database increase, the advantage grows. This paper describes the principles of GAST and reports a comparison of GAST with BLAT and Mega BLAST. The effects the query sequence length and the number of queries have on run times were studied using the full human genome and the chromosome 1 of human genome separately. Additionally, the error tolerance and behaviour of GAST when handling sequences with lower similarity to a database was studied. Lastly, we compared the quality of exon mappings produced by the three tools and the genomic
Confirmatory Factor Analysis of the Male Body Attitudes Scale (MBAS) among Spanish Adolescent Males

The aim of this study was to examine the factor structure of the Male Body Attitudes Scale (MBAS) among a sample of 212 adolescent males by conducting a confirmatory factor analysis. The data revealed that while muscularity and low body fat factors were appropriate for the male sample, the height factor was not supported. The composite MBAS-Spanish version (MBAS-S) and its two factors had high internal consistency and were not significantly related to the traditionally used measure of body image (Eating Disorder Inventory–Body Dissatisfaction [BD]), confirming that this subscale only appears to evaluate female body concerns. Correlations with psychological well-being variables (anxiety, emotional regulation, and self-esteem) supported the concurrent validity of the instrument. These findings provide further evidence in support of the hypothesis that BD in males has been inappropriately evaluated by measures designed specifically for females. Despite the fact that our results did not replicate the original factorial structure of the instrument, the MBAS-S presents adequate psychometric properties and can be considered as a valuable assessment tool for BD among adolescent males.
Attitude toward the Ad: An Assessment of Diverse Measurement Indices under Different Processing “Sets”

The authors examine two concerns that have emerged in research involving the attitude toward the ad (Aad) construct. The first pertains to conceptualization and measurement. Drawing on recent social cognition and consumer research, the authors propose a distinction for cognitive evaluation and affective reaction as separate dimensions of Aad. Empirical evidence is provided that supports the meaningfulness of this distinction in advertising-response data. The second concern involves processing set and its implications for the external validity of Aad research. The results suggest that processing individuals under disguised versus nondisguised “sets” will influence the nature of their affective versus cognitive responses to an ad.
Analysis of obesity-related outcomes and bariatric failure rates with the duodenal switch vs gastric bypass for morbid obesity.

OBJECTIVE To compare the outcomes of a large cohort undergoing biliopancreatic diversion/duodenal switch (DS) vs gastric bypass (GB). DESIGN Retrospective review of the Bariatric Outcomes Longitudinal Database from 2007 to 2010. All inpatient and outpatient follow-up data were analyzed. SETTING Multicenter database. PATIENTS Patients undergoing primary DS were compared with a concurrent cohort undergoing GB. MAIN OUTCOME MEASURES The main outcome measures were (1) weight loss; (2) control of comorbidities including diabetes mellitus, hypertension, and sleep apnea; and (3) failure to achieve at least 50% excess body weight loss. RESULTS One thousand five hundred forty-five patients underwent DS and 77 406 underwent GB, with a mean preoperative body mass index (BMI; calculated as weight in kilograms divided by height in meters squared) of 52 and 48, respectively (P < .01). The DS was associated with longer operative times, greater blood loss, and longer lengths of hospital stay (all P < .05). Early reoperation rates were higher in the DS group (3.3% vs 1.5%). Percentage of change in BMI was significantly greater in the DS group at all follow-up intervals (P < .05). Subgroup analysis of the superobese population (BMI >50) revealed significantly greater percentage of excess body weight loss in the DS group at 2 years (79% vs 67%; P < .01). Comorbidity control of diabetes, hypertension, and sleep apnea were all superior with the DS (all P < .05). The risk of weight loss failure was significantly reduced with DS vs GB for all patients, with a greater reduction in the BMI more than 50 subgroup. CONCLUSIONS The DS is a less commonly used bariatric operation, with higher early risks compared with GB. However, the DS achieved better weight and comorbidity control, with even more pronounced benefits among the superobese.
SEMIAUTOMATED FLUORIMETRIC DETERMINATION OF TYROSINE IN RAT BRAIN AND HUMAN PLASMA

Abstract— The evidence is presented to show that the fiuorimetric method of Waalkes & Udenfriend (1957) cannot be used directly for the determination of free tyrosine in acid deproteinized extracts of rat brain, owing to the reaction of peptide bound tyrosine in some proteins present in the acid extracts. A method is given to obtain a fraction containing free tyrosine in the acid extracts of rat brain and to determine its tyrosine content fluorimetrically by autoanalysis. An autoanalysis method is also given for the fiuorimetric determination of free tyrosine directly in 50 trichloroacetic acid extracts of the plasma.