Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of the neuronal nitric oxide synthase inhibitor 7-nitroindazole on methylphenidate-induced hyperlocomotion in mice

The psychostimulant methylphenidate (MPD) is used for the treatment of attention-deficit/hyperactivity disorders (ADHD) in adolescents. In the present study we investigated the effect of repeated administration of a low (10 mg/kg) and a high (40 mg/kg) dose of MPD on the locomotor activity of Swiss Webster mice, and the influence of inhibition of the neuronal nitric oxide synthase (nNOS) on MPD-induced hyperlocomotion. In the first experiment, mice were administered either vehicle or the nNOS inhibitor 7-nitroindazole (7-NI; 25 mg/kg), prior to the administration of MPD (10 or 40 mg/kg), for five consecutive days; injections were paired with the test cage (‘novel environment’) on days 1 and 5. A challenge injection of MPD (10 or 40 mg/kg), given after a 10-day drug-free period, resulted in sensitization to the motor stimulating effect of the low dose of MPD but tolerance to the high dose of MPD. 7-NI blocked the induction of sensitization but had no effect on the development of tolerance. The place-dependent-hyperlocomotion (e.g. conditioning) that developed after the administration of either the low or high dose of MPD was blocked by pretreatment with the nNOS inhibitor. In the second experiment, mice were administered MPD (10 or 40 mg/kg; 5 days) in their home cage and after a 10-day drug-free period were challenged with either vehicle/MPD or 7-NI/MPD. The low dose of MPD elicited a sensitized response that was blocked by the co-administration of 7-NI. The high dose of MPD produced neither sensitization nor tolerance; 7-NI did not affect the response to the high dose of MPD. These findings suggest: (a) MPD-induced sensitization and tolerance are dependent on the dose of the drug and the environment where the drug is delivered (home cage versus test cage); (b) context-dependent hyperlocomotion developed in the absence of a sensitized response to the drug; (c) nNOS is involved in the induction and expression of sensitization to MPD as well as in the conditioned locomotion produced by the drug; (d) no involvement of nNOS in the effects of a high dose of MPD was detected.
Defective expression of GPIb/IX/V complex in platelets from patients with May-Hegglin anomaly and Sebastian syndrome.

BACKGROUND AND OBJECTIVES May-Hegglin anomaly (MHA) and Sebastian syndrome (SBS) are inherited macrothrombocytopenias with D hle-like bodies in leukocytes. MHA-SBS are due to mutations of the gene (MYH9) for the heavy chain of non-muscle myosin IIA (NMMHC-IIA), the only myosin II expressed in platelets. The bleeding tendency is often more severe than expected on the basis of platelet count, but no abnormality of platelet function has been identified. To characterize platelet abnormalities deriving from MYH9 mutations better, we studied surface glycoproteins (GPs) in platelets from MHA-SBS patients. DESIGN AND METHODS Eight patients from 4 unrelated families were studied. Platelet surface GPs were studied by flow cytometry in both the whole platelet population and subpopulations of platelets identified according to their size. RESULTS Flow cytometry identified a defect of the GPIb/IX/V complex in the whole platelet population in 7 of 8 patients. Moreover, in all patients the subpopulation of large platelets had defective expression of this complex. INTERPRETATION AND CONCLUSIONS These findings indicate that MYH9 mutations may be responsible for reduced surface expression of GPIb/IX/V. This defect could contribute to the bleeding tendency of these patients. The identification of a GPIb/IX/V defect in MHA-SBS platelets raises the question of the differential diagnosis from heterozygous Bernard-Soulier syndrome.
Small games and long memories promote cooperation

Complex social behaviors lie at the heart of many of the challenges facing evolutionary biology, sociology, economics, and beyond. For evolutionary biologists in particular the question is often how such behaviors can arise \textit{de novo} in a simple evolving system. How can group behaviors such as collective action, or decision making that accounts for memories of past experience, emerge and persist? Evolutionary game theory provides a framework for formalizing these questions and admitting them to rigorous study. Here we develop such a framework to study the evolution of sustained collective action in multi-player public-goods games, in which players have arbitrarily long memories of prior rounds of play and can react to their experience in an arbitrary way. To study this problem we construct a coordinate system for memory-$m$ strategies in iterated $n$-player games that permits us to characterize all the cooperative strategies that resist invasion by any mutant strategy, and thus stabilize cooperative behavior. We show that while larger games inevitably make cooperation harder to evolve, there nevertheless always exists a positive volume of strategies that stabilize cooperation provided the population size is large enough. We also show that, when games are small, longer-memory strategies make cooperation easier to evolve, by increasing the number of ways to stabilize cooperation. Finally we explore the co-evolution of behavior and memory capacity, and we find that longer-memory strategies tend to evolve in small games, which in turn drives the evolution of cooperation even when the benefits for cooperation are low.
Tourism and Pilgrimage: Paying Homage to Literary Heroes

By exploring the experiences of visiting the grave of famous authors, this study highlights the place of literary tourism in the tourism pilgrimage literature. It is based on an observational study of visitors to the grave of Jean-Paul Sartre and Simone de Beauvoir in Paris. Analysis reveals that visitors were motivated by a desire for closeness, a wish to pay their respects and to acknowledge the influence on their life of the two writers. The study notes a strong parallel between the religious and the literary pilgrim and contributes to knowledge on the phenomenon of the secular pilgrimage. Copyright © 2015 John Wiley & Sons, Ltd.
Minimum-Energy Broadcast Using Practical Directional Antennas in All-Wireless Networks

Energy-efficient broadcast communication is an important problem in wireless ad hoc networks. Previously, minimum-energy broadcast that exploits the broadcast nature of radio transmission has been studied and shown to be NP-complete for omnidirectional antennas. In this paper, we investigate the minimum-energy broadcast problem under a wide spectrum of directional antenna models, including sectored antennas with fixed sectors and beamwidth and antenna array-based smart antennas with varying degrees of beam orientation and beamwidth. We first propose the RF design and implementation of each model, which suggests the practical parameters of antennas under that model. We then show that the minimum-energy broadcast problem under each of the antenna models is NP-complete. Lastly, we present a heuristic algorithm based on BIP for the above problem under each directional antenna model and experimentally compare the energy efficiency of using different directional antennas using these heuristics. Our results show that using antennas with adjustable orientation and variable beamwidth gives the best results. For such antennas, the scanning angle is the dominant factor in improving the quality of the broadcast trees. The number of antennas per node is not that critical to obtaining a better broadcast tree as long as it is large enough to cover the entire 360◦ around a node so as to prevent network partitioning.
Sensitivity of human auditory cortex to rapid frequency modulation revealed by multivariate representational similarity analysis

Functional Magnetic Resonance Imaging (fMRI) was used to investigate the extent, magnitude, and pattern of brain activity in response to rapid frequency-modulated sounds. We examined this by manipulating the direction (rise vs. fall) and the rate (fast vs. slow) of the apparent pitch of iterated rippled noise (IRN) bursts. Acoustic parameters were selected to capture features used in phoneme contrasts, however the stimuli themselves were not perceived as speech per se. Participants were scanned as they passively listened to sounds in an event-related paradigm. Univariate analyses revealed a greater level and extent of activation in bilateral auditory cortex in response to frequency-modulated sweeps compared to steady-state sounds. This effect was stronger in the left hemisphere. However, no regions showed selectivity for either rate or direction of frequency modulation. In contrast, multivoxel pattern analysis (MVPA) revealed feature-specific encoding for direction of modulation in auditory cortex bilaterally. Moreover, this effect was strongest when analyses were restricted to anatomical regions lying outside Heschl's gyrus. We found no support for feature-specific encoding of frequency modulation rate. Differential findings of modulation rate and direction of modulation are discussed with respect to their relevance to phonetic discrimination.
Physical Self-Perceptions in Adolescence

This study examines the generalizability of the form, structural parameters, and latent means of a hierarchical multidimensional model of physical self-perceptions in adolescents from three cultures. A children's version of the physical self-perception profile (PSPP-C) was administered to samples of British, Hong Kong, and Russian high school students. A structural equation model that hypothesized a hierarchical structure with global self-esteem as a super ordinate construct and physical self-worth as a domain-level construct governing the PSPP-C subdomains fit the data adequately. Tests of the cross-cultural generalizability of the proposed model supported the invariance of the factor pattern and model parameters across the samples. Latent means analysis suggested that the factor means were significantly higher in the British sample, a finding that supports the results of cross-cultural studies of self-esteem in other domains.
PENGARUH KEPEMIMPINAN, KOMUNIKASI DAN LINGKUNGAN KERJA TERHADAP SEMANGAT KERJA PEGAWAI PADA PT. ANGKASA PURA 1 DIVISI KOMERSIAL

Efficacy of company in giving service to consumer very determined by human resource had. reliable human resource have ability, skillful, and high loyalitas to each duty area, so that they earn to execute duty very seriously and full of responsibility and also have the spirit of and job of loyalitas high to company Target of this research is to know influence of leadership, communications, and environment work to spirit of job at PT. Ankasa Gate 1 Commercial Division of Bali. By using counted 32 respoden, data-processing use doubled regresi with test of f test and of t. Pursuant to result of analysis found that leadership, environment and communications work by simultan have an effect on signifikan to spirit of officer job. Leadership, environment and communications work by parsial have an effect on signifikan to spirit of officer job. Leadership variable have an effect on dominant to spirit of job at PT. Space Gate 1Divisi is Commercial of Bali. Suggestion the given is to revise leadership and give coherent sanction to officer doing collision, intensifying open communications between subordinate and head, re-arranging balmy work path and hygiene of job environment Keyword: Leadership, Communications, Environmental of Job, Spirit of job
A Live Birth Subsequent to IVF following Egg Retrieval Only 12 Hours after hCG Priming

Introduction. To report a live birth following egg retrieval after only 12 hours from hCG priming. Patients. A childless couple with five-years-lasting secondary infertility. Methods. IVF was performed according to the long protocol. Two immature oocytes were retrieved following only 12 hours after hCG priming due to the patient misunderstanding. The eggs were cultured in vitro and ICSI was performed following polar body extruded after 24 hours in culture. After additional 24 hours a 4-cell embryo was developed and ET was performed. Results. A viable pregnancy was achieved and a healthy baby girl was delivered at 38 weeks of gestation. Conclusion. In a rare and unexpected situation when immature oocytes are retrieved following a short hCG priming, the eggs should be cultured in vitro, late ICSI should be performed, and a pregnancy may be expected.
Stimulating Knowledge Sharing by Error Management and Leader-Member Exchange: Psychological Safety as a Mediator

The present study investigated how knowledge sharing within teams is related to employees’perceptions of the work environment. Questionnaires measuring error management, leadermemberexchange (LMX), psychological safety, and knowledge sharing were administered to159 Dutch and Romanian employees from 51 teams in 8 organizations. Hierarchical regressionanalysis showed that error management and LMX were significantly related to knowledge sharingand that these relationships were mediated by psychological safety. The results for the Dutchand the Romanian samples were not significantly different. It was concluded that, to stimulateknowledge sharing, managers should create safety feelings within teams by being more lenientwhen subordinates make errors and by building trustful relationships with their subordinates
Expanding textual entailment corpora fromWikipedia using co-training

In this paper we propose a novel method to automatically extract large textual entailment datasets homogeneous to existing ones. The key idea is the combination of two intuitions: (1) the use of Wikipedia to extract a large set of textual entailment pairs; (2) the application of semisupervised machine learning methods to make the extracted dataset homogeneous to the existing ones. We report empirical evidence that our method successfully expands existing textual entailment corpora.
PROMOTING RESILIENCE IN YOUNG PEOPLE IN LONG‐TERM CARE — THE RELEVANCE OF ROLES AND RELATIONSHIPS IN THE DOMAINS OF RECREATION AND WORK

This paper seeks to highlight the resilience‐enhancing potential for vulnerable young people of roles and relationships in the domains of recreation and work. The paper explores its theme through a specific focus on the needs of young people in long‐term care. The paper has four sections: the first deals with some key conceptual propositions relevant to understanding resilience‐related processes; the second with the resilience‐enhancing potential of recreational activities; the third with the resilience‐enhancing potential of work roles; and the fourth with the implications for practices by carers and professionals in relation to helping young people in care to derive benefits from the positives that recreation and work experiences may have to offer. The paper reviews relevant research evidence from a range of perspectives and through related case examples.
Contribution of short sleep duration to ethnic differences in cardiovascular disease: results from a cohort study in the Netherlands

Objectives We analysed association between short sleep duration and prevalence of cardiovascular disease (CVD) in a multiethnic population living in the Netherlands, and the contribution of short sleep to the observed ethnic differences in the prevalence of CVD, independent of CVD risk factors. Methods 20 730 participants (aged 18–71 years) of the HELIUS (Healthy Life in an Urban Setting) Study were investigated. Self-reported sleep duration was classified as: short (<7 hours/night) and healthy (7–9 hours/night). Prevalence of CVD was assessed using the Rose Questionnaire on angina pectoris, intermittent claudication and possible myocardial infarction. Association of short sleep duration with prevalent CVD and the contribution of short sleep to the observed ethnic differences in the prevalence of CVD were analysed using adjusted prevalence ratio(s) (PRs) with 95% CI. Results Results indicate that short sleep was associated with CVD among all ethnic groups with PRs ranging from 1.41 (95% CI 1.21 to 1.65) in Moroccans to 1.62 (95% CI 1.20 to 2.18) in Dutch after adjustment for age, sex and conventional CVD risk factors. The independent contributions of short sleep (in percentage) to ethnic differences in CVD compared with Dutch were 10%, 15%, 15%, 5% and 5% in South-Asian Surinamese, African-Surinamese, Ghanaian, Turkish and Moroccan, respectively. Conclusion Short sleep contributed to ethnic differences in CVD independent of well-known CVD risk factors particularly in Surinamese and Ghanaian groups. Reducing sleep deprivation may be a relevant entry point for reducing increased CVD risks among the various ethnic minority groups.
Differential Effects of Age on Brain Gray Matter in Bipolar Patients and Healthy Individuals

This study examined possible differences in total gray and white matter brain content in bipolar patients and healthy individuals, and their relationship with age. 22 DSM-IV bipolar patients and 22 healthy controls underwent a 1.5-tesla Spoiled Gradient Recalled Acquisition (SPGR) MRI. Evaluators blind to patients’ identities measured total brain, gray and white matter volumes using a semi-automated software. No differences were found for total brain volume, gray matter or white matter volumes between bipolar patients and healthy controls (MANCOVA, age as covariate, p > 0.05). Age was inversely correlated with total gray matter volume in patients (r = –0.576, p = 0.005), but not in controls (r = –0.193, p = 0.388). Our findings suggest that any existing gray matter deficits in bipolar disorder are likely to be localized to specific brain regions, rather than generalized. The inverse correlation between age and brain gray matter volumes in bipolar patients, not present in healthy controls, in this sample of mostly middle-aged adults, could possibly indicate more pronounced age-related gray matter decline in bipolar patients, and may be of potential relevance for the pathophysiology of the disorder.
The rexinoid LG100268 and the synthetic triterpenoid CDDO-methyl amide are more potent than erlotinib for prevention of mouse lung carcinogenesis

Female A/J mice injected with the carcinogen vinyl carbamate develop atypical adenomatous hyperplasias in lungs 4 weeks after injection with the carcinogen. The number and severity of tumors then increase over time, making these mice a useful model for evaluating potential chemopreventive agents. The rexinoid LG100268 (LG268), a selective ligand for the retinoid X receptor, and the methyl amide of the synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid (CDDO) both significantly reduced the number, size, and severity of the histopathology of lung tumors in female A/J mice when fed in diet for 14 to 20 weeks. The total tumor burden was 85% to 87% lower in mice fed LG268 and CDDO-MA than in controls, and the percentage of high-grade tumors decreased from 59% in the controls to 25% or 30% with CDDO-MA and LG268. Erlotinib, which is used to treat lung cancer patients and is an inhibitor of the epidermal growth factor receptor, was less effective in this model. Immunohistochemical staining of geminin, a marker of cell cycle progression, was higher in lung sections from control mice than in mice treated with LG268. Because rexinoids and triterpenoids signal through different biological pathways, they should be tested in combination for the prevention of lung cancer. [Mol Cancer Ther 2008;7(5):1251–7]
Information Technology and Educational Amnesia

Waves of enthusiasm for technological innovations that promise to revitalize teaching and learning are at least a century old. Unfortunately, the record of accomplishment for the many varieties of hardware and software introduced into schools over the decades is remarkably thin. Today's promoters of technology in education tend to forget similar efforts in the past, launching forth with initiatives that use the latest hardware and software, as if such projects were unprecedented. While initiatives like the iClass network in Europe show considerable promise, their development would benefit from recalling the history of earlier attempts to develop and market sophisticated technical instruments for the schools. Reflection up basic philosophical questions about teaching and learning can help us decide which technical devices are of genuine value and which are not.
AMP: Program Context Specific Buffer Caching

We present Adaptive Multi-Policy disk caching (AMP), which uses multiple caching policies within one application, and adapts both which policies to use and their relative fraction of the cache, based on program-context specific information. AMP differentiate disk requests based on the program contexts, or code locations, that issue them. Compared to recent work, AMP is unique in that it employs a new robust scheme for detecting looping patterns in access streams, as well as a low-overhead randomized way of managing many cache partitions. We show that AMP outperforms non-detection-based caching algorithms on a variety of workloads by up to 50% in miss rate reduction. Compared to other detection-based schemes, we show that AMP detects access patterns more accurately for a series of synthesized workloads, and incurs up to 15% fewer misses for one application trace.
Perceptions of the Best and Worst Climates for Creativity: Preliminary Validation Evidence for the Situational Outlook Questionnaire

This article reports the results of 2 studies conducted to examine the ability of the Situational Outlook Questionnaire(tm) (SOQ) to effectively discern climates that either encourage or discourage creativity and the ability to initiate change. The purpose of the studies is to examine the concurrent criterion-related validity of the SOQ. The climate for creativity and change is defined, and the context for the use of the measure in organizational settings is established through the development of a model for organizational change. The article presents the history of the SOQ's development and gives a description of the SOQ. The methodology and results of both studies, including 3 groups, are reported. The results of both studies show that when individuals complete the SOQ based on their recollection of a best- and worst-case work experience, the measure is able to consistently and significantly discriminate between the 2 types of experiences. Conclusions, implications, and areas for future research to further examine the validity of the SOQ are explored.
Indian Fathers: Family Dynamics and Investment Patterns

Despite unprecedented economic and social changes within the Indian family, not much attention is paid to the role of the father in the socialisation of young children. This overview provides a contemporary look at the Indian father in the context of ideological beliefs about roles and responsibilities, levels and quality of involvement with infants and young children, and maternal employment and caregiving patterns. Ideological beliefs about men’s and women’s roles and responsibilities within the family have not changed appreciably. Fathers appear responsive to the needs of young children, but mothers still assume major responsibility for childrearing. Maternal employment affects caregiving patterns modestly. There is a need for studies on fathers’ involvement and investment in infants and young children within changing work and family patterns using more complex research designs.