Miracle-dz/UniFAR-FTUs huggingface dataset:
Monitoring of early human fetal development in women exposed to large doses of chemicals

The toxicological in‐patient hospital in Budapest responsible for the care of chemically poisoned persons from a population of 3 million. A population‐based prospective epidemiological study of all pregnant women admitted from 1985 to 1993 was used to evaluate effects of large doses of chemicals on human fetal development. Of 559 self‐poisoned pregnant women identified, two died from the poisoning. A total of 213 fetuses were in the first month of their postconception development. Of these, 126 had evaluated pregnancy outcomes: 111 ended in is very early loss, 3 ended in clinical miscarriage, and 12 survived to delivery. (In addition 73 pregnancies were terminated and one pregnant woman died.) The 12 liveborn infants had two congenital abnormalities that were probably not related to their mother's self‐poisoning. Though based on small numbers, these findings are consistent with an “all‐or‐nothing” effect of chemical poisoning very early in human gestation. Environ. Mol. Mutagen. 30:240–244, 1997. © 1997 Wiley‐Liss, Inc.
Image Encryption Based on Diffusion and Multiple Chaotic Maps

In the recent world, security is a prime important issue, and encryption is one of the best alternative way to ensure security. More over, there are many image encryption schemes have been proposed, each one of them has its own strength and weakness. This paper presents a new algorithm for the image encryption/decryption scheme. This paper is devoted to provide a secured image encryption technique using multiple chaotic based circular mapping. In this paper, first, a pair of sub keys is given by using chaotic logistic maps. Second, the image is encrypted using logistic map sub key and in its transformation leads to diffusion process. Third, sub keys are generated by four different chaotic maps. Based on the initial conditions, each map may produce various random numbers from various orbits of the maps. Among those random numbers, a particular number and from a particular orbit are selected as a key for the encryption algorithm. Based on the key, a binary sequence is generated to control the encryption algorithm. The input image of 2-D is transformed into a 1- D array by using two different scanning pattern (raster and Zigzag ) and then divided into various sub blocks. Then the position permutation and value permutation is applied to each binary matrix based on multiple chaos maps. Finally the receiver uses the same sub keys to decrypt the encrypted images. The salient features of the proposed image encryption method are loss-less, good peak signal –to noise ratio (PSNR), Symmetric key encryption, less cross correlation, very large number of secret keys, and key-dependent pixel value replacement.
A Grapheme-Based Approach for Accent Restoration in Gikuyu

The orthography of Gikuyu includes a number of accented characters to represent the entire vowel system. These characters are however not readily available on standard computer keyboards and are usually represented as the nearest available character. This can render reading and understanding written texts more difficult. This paper describes a system that is able to automatically place these accents in Gikuyu text on the basis of local graphemic context. This approach avoids the need for an extensive digital lexicon, typically not available for resource-scarce languages. Using an extended trigram based-approach, the experiments show that this method can achieve a very high accuracy even with a limited amount of digitally available textual data. The experiments on Gikuyu are contrasted with experiments on French, German and Dutch.
Formation of acrylamide at temperatures lower than 100°C: the case of prunes and a model study

Acrylamide concentrations in prune products – baby strained prunes (range = 75–265 µg kg−1), baby apple/prune juice (33–61 µg kg−1), prune juice (186–916 µg kg−1) and prunes (58–332 µg kg−1) – on the Canadian market were determined. The formation of acrylamide in a simulated plum juice was also investigated under ‘drying conditions’ in an open vessel at temperatures <100°C for 24 h and under ‘wet conditions’ in a closed vessel at a temperature of 120°C for 1 h. Acrylamide was produced in a simulated plum juice under ‘drying conditions’ in amounts comparable with those found in prunes and prune juices. Acrylamide was not produced in simulated plum juice under ‘wet conditions’ in a closed vessel at temperature of 120°C for 1 h, but under the same condition an authentic prune juice doubled its acrylamide concentration. Formation of acrylamide in prune products was attributed to the presence of asparagine and sugars in the starting materials.
Fetal alcohol exposure increases mammary tumor susceptibility and alters tumor phenotype in rats.

BACKGROUND Altered fetal programming because of a suboptimal in utero environment has been shown to increase susceptibility to many diseases later in life. This study examined the effect of alcohol exposure in utero on N-nitroso-N-methylurea (NMU)-induced mammary cancer risk during adulthood. METHODS Study 1: Pregnant Sprague Dawley rats were fed a liquid diet containing 6.7% ethanol (alcohol-fed), an isocaloric liquid diet (pair-fed), or rat chow ad libitum (ad lib-fed) from day 11 to 21 of gestation. At birth, female pups were cross-fostered to ad lib-fed control dams. Adult offspring were given an I.P. injection of NMU at a dose of 50 mg/kg body weight. Mammary glands were palpated for tumors twice a week, and rats were euthanized at 23 weeks postinjection. Study 2: To investigate the role of estradiol (E2), animals were exposed to the same in utero treatments but were not given NMU. Serum was collected during the preovulatory phase of the estrous cycle. RESULTS At 16 weeks postinjection, overall tumor multiplicity was greater in the offspring from the alcohol-fed group compared to the control groups, indicating a decrease in tumor latency. At study termination, 70% of all animals possessed tumors. Alcohol-exposed animals developed more malignant tumors and more estrogen receptor-α-negative tumors relative to the control groups. In addition, IGF-binding protein-5 (IGFBP-5) mRNA and protein were decreased in tumors of alcohol-exposed animals. Study 2 showed that alcohol-fed animals had significantly increased circulating E2 when compared to either control group. CONCLUSIONS These data indicate that alcohol exposure in utero increases susceptibility to mammary tumorigenesis in adulthood and suggest that alterations in the IGF and E2 systems may play a role in the underlying mechanism.
4D frequency analysis of computational cameras for depth of field extension

Depth of field (DOF), the range of scene depths that appear sharp in a photograph, poses a fundamental tradeoff in photography---wide apertures are important to reduce imaging noise, but they also increase defocus blur. Recent advances in computational imaging modify the acquisition process to extend the DOF through deconvolution. Because deconvolution quality is a tight function of the frequency power spectrum of the defocus kernel, designs with high spectra are desirable. In this paper we study how to design effective extended-DOF systems, and show an upper bound on the maximal power spectrum that can be achieved. We analyze defocus kernels in the 4D light field space and show that in the frequency domain, only a low-dimensional 3D manifold contributes to focus. Thus, to maximize the defocus spectrum, imaging systems should concentrate their limited energy on this manifold. We review several computational imaging systems and show either that they spend energy outside the focal manifold or do not achieve a high spectrum over the DOF. Guided by this analysis we introduce the lattice-focal lens, which concentrates energy at the low-dimensional focal manifold and achieves a higher power spectrum than previous designs. We have built a prototype lattice-focal lens and present extended depth of field results.
The Traumatology of Life

As Ground Zero was still smoldering and the frantic search for survivors continued, Charles Figley and Joseph Boscarino met nearby at 100 Avenue of the Americas in New York City to discuss studying the impact of the terrorist attacks which had occurred just days ago. The authors were no strangers to studying trauma survivors. Figley and Boscarino had collaborated since 1981 on efforts to understand PTSD and the consequences of combat on those who fought in the Vietnam War.
Cell cycle regulation and interneuron production

The regulation of progenitor proliferation in developing brain in has been extensively studied in the cerebral cortex, but relatively little is known about progenitor divisions in ventral germinal zones. Recent observations pertinent to interneuron genesis in the ventral forebrain, especially in the medial ganglionic eminence, indicate similarities to cerebral cortical neurogenesis and hint at some interesting differences between ventral and dorsal telencephalon progenitors. Proliferation within the ganglionic eminences is discussed from the vantage point of neural precursor cell cycles, especially G1‐phase, and current models of neurogenic divisions in cortex that may apply to ventral forebrain as well. © 2010 Wiley Periodicals, Inc. Develop Neurobiol 71: 2–9, 2011
Detection of Faint BLR Components in the Starburst/Seyfert Galaxy NGC 6221 and Measure of the Central BH Mass

In the last decade, using single epoch virial based techniques in the optical band, it has been possible to measure the central black hole mass on large AGN1 samples. However these measurements use the width of the broad line region as a proxy of the virial velocities and are therefore difficult to be carried out on those obscured (type 2) or low luminosity AGN where the nuclear component does not dominate in the optical. Here we present the optical and near infrared spectrum of the starburst/Seyfert galaxy NGC 6221, observed with X-shooter/VLT. Previous observations of NGC 6221 in the X-ray band show an absorbed (N_H=8.5 +/- 0.4 x 10^21 cm^-2) spectrum typical of a type 2 AGN with luminosity log(L_14-195 keV) = 42.05 erg/s, while in the optical band its spectrum is typical of a reddened (A_V=3) starburst. Our deep X-shooter/VLT observations have allowed us to detect faint broad emission in the H_alpha, HeI and Pa_beta lines (FWHM ~1400-2300 km/s) confirming previous studies indicating that NGC 6221 is a reddened starburst galaxy which hosts an AGN. We use the measure of the broad components to provide a first estimate of its central black hole mass (M_BH = 10^(6.6 +/- 0.3) Msol, lambda_Edd=0.01-0.03), obtained using recently calibrated virial relations suitable for moderately obscured (N_H<10^24 cm^-2) AGN.
Joint Relay and Antenna Selection for Dual-Hop Amplify-and-Forward MIMO Relay Networks

Four joint relay and antenna selection strategies for dual-hop amplify-and-forward (AF) multiple-input multiple-output relay networks are studied. Two of them require full channel state information (CSI) whereas the other two require only partial CSI. The relays are either channel-assisted AF or fixed-gain AF type. The first joint selection strategy involves choosing the best relay and the best single transmit antennas at the source and the relay. The second strategy jointly involves choosing the best relay and the best single transmit/receive antenna pairs at the source-to-relay and relay-to-destination channels. Moreover, two partial selection strategies, which can be used when the global CSI is not available, are also proposed and analyzed. In order to quantify the system performance analytically, the exact outage probability of all selection strategies is derived in closed-form. Direct insights into the system-design are obtained by deriving the asymptotic outage probability, asymptotic average symbol error rate, diversity order and array gain.
Model-Based Security Analysis of a Water Treatment System

An approach to analyzing the security of a cyber-physical system (CPS) is proposed, where the behavior of a physical plant and its controller are captured in approximate models, and their interaction is rigorously checked to discover potential attacks that involve a varying number of compromised sensors and actuators. As a preliminary study, this approach has been applied to a fully functional water treatment testbed constructed at the Singapore University of Technology and Design. The analysis revealed previously unknown attacks that were confirmed to pose serious threats to the safety of the testbed, and suggests a number of research challenges and opportunities for applying a similar type of formal analysis to cyber-physical security.
Forest-to-pasture conversion increases the diversity of the phylum Verrucomicrobia in Amazon rainforest soils

The Amazon rainforest is well known for its rich plant and animal diversity, but its bacterial diversity is virtually unexplored. Due to ongoing and widespread deforestation followed by conversion to agriculture, there is an urgent need to quantify the soil biological diversity within this tropical ecosystem. Given the abundance of the phylum Verrucomicrobia in soils, we targeted this group to examine its response to forest-to-pasture conversion. Both taxonomic and phylogenetic diversities were higher for pasture in comparison to primary and secondary forests. The community composition of Verrucomicrobia in pasture soils was significantly different from those of forests, with a 11.6% increase in the number of sequences belonging to subphylum 3 and a proportional decrease in sequences belonging to the class Spartobacteria. Based on 99% operational taxonomic unit identity, 40% of the sequences have not been detected in previous studies, underscoring the limited knowledge regarding the diversity of microorganisms in tropical ecosystems. The abundance of Verrucomicrobia, measured with quantitative PCR, was strongly correlated with soil C content (r = 0.80, P = 0.0016), indicating their importance in metabolizing plant-derived carbon compounds in soils.
Interactive Customer Knowledge Management Systems : a Comparative Evaluation of Users ’ Perception of Trust and Level of Knowledge

This paper aimed at examining the role of various interactive technologies in aiding Electronic Customer Knowledge Management Systems (E-CKMS). The development of E-CKMS encounters several challenges including trust and knowledge hoarding, and comparative studies that evaluate the potential of interactive technologies are lacking. Therefore, an investigation was carried out to uncover this potential, and measure users’ perception of trust and level of knowledge in three E-CKMS interaction modes. This involved implementing three E-CKMS experimental platforms (text with graphics only (VCKMS), one aided by speech with earcons, and auditory icons (MCKMS), and another enhanced with speech, earcons, and facial expressions (ACKMS)). Three groups of users (n=20 each) were instructed to test the three platforms independently, and fill a questionnaire devised to measure aspects of perception of trust and level of knowledge. Results suggested that levels of users’ trust and knowledge were higher in the interactive conditions than in the traditional approach. Key-Words: Customer, Knowledge, Interactive, Trust, Earcons, Auditory icons, Facial Expressions, Speech
Feature-Rich Part-of-speech Tagging for Morphologically Complex Languages: Application to Bulgarian

We present experiments with part-of-speech tagging for Bulgarian, a Slavic language with rich inflectional and derivational morphology. Unlike most previous work, which has used a small number of grammatical categories, we work with 680 morpho-syntactic tags. We combine a large morphological lexicon with prior linguistic knowledge and guided learning from a POS-annotated corpus, achieving accuracy of 97.98%, which is a significant improvement over the state-of-the-art for Bulgarian.
Chronic Myelogenous Leukemia : A Concise Update

HRONIC MYELOGENOUS leukemia (CML) is a C clonal myeloproliferative disorder of the primitive hematopoietic stem cell. ’-3 It involves the myeloid, erythroid, megakaryocytic, B-, and sometimes T-lymphoid elements, but not the marrow fibrobla~ts. ~,~ CML is characterized by (1) the heterogeneity of the disease among patients, (2) a biphasic or triphasic course, and (3) the presence of a chromosomal marker, the Philadelphia chromosome (Ph), in the leukemic Proliferation is a shared feature of CML and other myeloproliferative disorders such as essential thrombocytosis, polycythemia vera, and myeloid metaplasia/myelofibrosis. Although these entities are usually distinct, overlap in presentation is occasionally observed, resulting in diagnostic confusion. Thus, it is important to confirm the diagnosis of CML by cytogenetic (Ph chromosome) or molecular studies, because the natural history and treatment of the myeloproliferative disorders are different.
Left Ventricular Outflow Tract Obstruction in Hypertrophic Cardiomyopathy Patients Without Severe Septal Hypertrophy: Implications of Mitral Valve and Papillary Muscle Abnormalities Assessed Using Cardiac Magnetic Resonance and Echocardiography.

BACKGROUND In patients with hypertrophic cardiomyopathy and left ventricular outflow tract (LVOT) obstruction, but without basal septal hypertrophy, we sought to identify mitral valve (MV) and papillary muscle (PM) abnormalities that predisposed to LVOT obstruction, using echo and cardiac magnetic resonance. METHODS AND RESULTS We studied 121 patients with hypertrophic cardiomyopathy hypertrophic cardiomyopathy (age, 49±17 years; 60% men; 57% on β-blockers) with a basal septal thickness of ≤1.8 cm who underwent echocardiography (rest+stress) and cine cardiac magnetic resonance. Echo measurements included maximal LVOT gradient (rest/provocable), MV leaflet length (parasternal long, 4 and 3-chamber views), and abnormal chordal attachment to mid/base of anterior MV. Cine cardiac magnetic resonance measurements included basal septal thickness, number/area of PM heads, and bifid PM mobility (in systole and diastole). Mean basal septal thickness, LVOT gradient, and LV ejection fraction were 1.5±0.3 cm, 72±54 mm Hg, and 61±6%, respectively. The number of anterolateral and posteromedial PM heads was 2.7±0.7 and 2.6±0.7, respectively. Anterolateral and posteromedial PM areas were 19.9±7 cm(2) and 17.1±6 cm(2), respectively. PM mobility was 11±6°. On multivariable analysis, predictors of maximal LVOT gradient were basal septal thickness, bifid PM mobility, anterior mitral leaflet length, and abnormal chordal attachment to base of anterior mitral leaflet. Forty-five patients underwent surgery to relieve LVOT obstruction, of which 52% needed an additional nonmyectomy (MV repair/replacement or PM reorientation) approach. CONCLUSIONS In hypertrophic cardiomyopathy patients without significant LV hypertrophy, in addition to basal septal thickness, anterior MV length, abnormal chordal attachment, and bifid PM mobility are associated with LVOT obstruction. In such patients, additional procedures on MV and PM (±myectomy) could be considered.
Optimizing a Personalized Multigram Cellphone Keypad

Current layouts for alphabetic input on mobile phone keypads are very inefficient. We propose a genetic algorithm (GA) to find a suitable keypad layout for each user, based on their personal text history. It incorporates codes for frequent multigrams, which may be directly input. This greatly reduces the average number of strokes required for typing. We optimize for two-handed use, the left thumb covering the leftmost rows and vice versa. The GA mini- mizes the number of strokes, consecutive use of the same key, and consecutive use of the same hand. Using these criteria, the algorithm re-arranges the 26 alphabetic characters, plus 14 additional multigrams, on the 10-key pad. We demonstrate that this arrangement can generate a more effective layout, especially for SMS-style messages. Substantial savings are verified by both computational analysis and human evaluation.
Paired electron pockets in the hole-doped cuprates

We propose a theory for the underdoped hole-doped cuprates, focusing on the “nodal-anti-nodal dichotomy” observed in recent experiments. Our theory begins with an ordered antiferromagnetic Fermi liquid with electron and hole pockets. We argue that it is useful to consider a quantum transition at which the loss of antiferromagnetic order leads to a hypothetical metallic “algebraic charge liquid” (ACL) with pockets of charge −e and +e fermions, and an emergent U(1) gauge field; the instabilities of the ACL lead to the low temperature phases of the underdoped cuprates. The pairing instability leads to a superconductor with the strongest pairing within the −e Fermi pockets, a d-wave pairing signature for electrons, and very weak nodal-point pairing of the +e fermions near the Brillouin zone diagonals. The influence of an applied magnetic field is discussed using a proposed phase diagram as a function of field strength and doping. We describe the influence of gauge field and pairing fluctuations on the quantum Shubnikov-de Haas oscillations in the normal states induced by the field. For the finite temperature pseudogap region, our theory has some similarities to the phenomenological two-fluid model of −2e bosons and +e fermions proposed by Geshkenbein, Ioffe, and Larkin [Phys. Rev. B 55, 3173 (1997)], which describes anomalous aspects of transverse transport in a magnetic field.
Cardamonin Inhibits Metastasis of Lewis Lung Carcinoma Cells by Decreasing mTOR Activity

The mammalian target of rapamycin (mTOR) regulates the motility and invasion of cancer cells. Cardamonin is a chalcone that exhibits anti-tumor activity. The previous study had proved that the anti-tumor effect of cardamonin was associated with mTOR inhibition. In the present study, the anti-metastatic effect of cardamonin and its underlying molecule mechanisms were investigated on the highly metastatic Lewis lung carcinoma (LLC) cells. The proliferation, invasion and migration of LLC cells were measured by MTT, transwell and wound healing assays, respectively. The expression and activation of mTOR- and adhesion-related proteins were assessed by Western blotting. The in vivo effect of cardamonin on the metastasis of the LLC cells was investigated by a mouse model. Treated with cardamonin, the proliferation, invasion and migration of LLC cells were significantly inhibited. The expression of Snail was decreased by cardamonin, while that of E-cadherin was increased. In addition, cardamonin inhibited the activation of mTOR and its downstream target ribosomal S6 kinase 1 (S6K1). Furthermore, the tumor growth and its lung metastasis were inhibited by cardamonin in C57BL/6 mice. It indicated that cardamonin inhibited the invasion and metastasis of LLC cells through inhibiting mTOR. The metastasis inhibitory effect of cardamonin was correlated with down-regulation of Snail and up-regulation of E-cadherin.