Miracle-dz/UniFAR-FTUs huggingface dataset:
Cheat-Proof Playout for Centralized and Serverless Online Games

We explore exploits possible for cheating in realtime, multiplayer games for both client-server and serverless architectures. We offer the first formalization of cheating in online games and propose an initial set of strong solutions. We propose a protocol that has provable anti-cheating guarantees, is provably safe and live, but suffers a performance penalty. We then develop an extended version of this protocol, called asynchronous synchronization, which avoids the penalty, is serverless, offers provable anticheating guarantees, is robust in the face of packet loss, and provides for significantly increased communication performance. This technique is applicable to common game features as well as clustering and cellbased techniques for massively multiplayer games. Specifically, we provide a zero-knowledge proof protocol so that players are within a specific range of each other, and otherwise have no notion of their distance. Our performance claims are backed by analysis using a simulation based on real game traces.
A high-sensitivity fully passive wake-up radio front-end for wireless sensor nodes

A high-sensitivity fully passive 868-MHz wake-up radio (WUR) front-end for wireless sensor network nodes is presented. The front-end does not have an external power source and extracts the entire energy from the radio-frequency (RF) signal received at the antenna. A high-efficiency differential RF-to-DC converter rectifies the incident RF signal and drives the circuit blocks including a low-power comparator and reference generators; and at the same time detects the envelope of the on-off keying (OOK) wake-up signal. The front-end is designed and simulated 0. 13μm CMOS and achieves a sensitivity of -33 dBm for a 100 kbps wake-up signal.
TECHNIQUE FAILURE IN PERITONEAL DIALYSIS PATIENTS: INSIGHTS AND CHALLENGES

161 Technique failure (TF) in peritoneal dialysis (PD) patients is an important metric to track and understand. It can be used as an indicator of the quality of PD care in dialysis programs and is also a means to identify barriers to expanding PD utilization among the prevalent dialysis population. There are a number of reasons why individuals discontinue PD therapy. Patients may die or require a switch to hemodialysis (HD) due to infectious complications (e.g., PD peritonitis), mechanical complications (e.g., primary catheter failure), inadequate solute clearance, ultrafiltration failure, or psychosocial issues. In addition, patients that receive a transplant no longer require PD treatment. The majority of TF occurs during the first 2 years of therapy and age, black race, female sex, increased body mass index, decreased cholesterol levels, submodality (automated PD vs continuous ambulatory PD), high transport status, and center experience (cumulative experience and degree of specialization toward PD) have all been identified as risk factors (1–4). Previous work has also shown that the reasons for TF appear to evolve over time. Problems with PD catheters and psychosocial reasons for TF are most common early in the treatment course, ultrafiltration failure tends to become more common later, and infectious complications occur at a constant rate over time (5). In this issue of Peritoneal Dialysis International, Kolesnyk et al. (6) report the results of a retrospective analysis of data from the Netherlands Cooperative Study on the Adequacy of Dialysis (NECOSAD). They concluded that TF was highest during the first few months after the start of therapy. They also noted that transplantation was the main reason to stop PD therapy in their cohort and that transplantation and death became more common over time. Catheter and abdominal complications as well as psychosocial reasons for TF were most common early in the treatment course. Age, cardiovascular disease, diabetes mellitus, and residual glomerular filtration rate were identified as important predictors of TF, while center and submodality were not. This analysis has several strengths. First, it is a relatively large contemporary cohort of incident PD patients from 38 centers. Second, it confirms the findings of preTECHNIQUE FAILURE IN PERITONEAL DIALYSIS PATIENTS: INSIGHTS AND CHALLENGES
Transforming healthcare and medical telemetry through cognitive radio networks

The Wireless Medical Telemetry Services (WMTS) band has been established by the FCC in the United States for transmission of data related to a patient¿s health, and similar reserved channels exist for life-critical communications throughout the world. However, transmissions in the WMTS band are severely hampered by interferences from adjacent digital television channels, and due to non-uniform access priority, as this band is also shared by utility telemetry and government installations. In this article, we propose the use of cognitive radio technology to dynamically utilize the WMTS frequencies based on the activity patterns of the high priority users, and the quality of service constraints of the patients¿ data, while ensuring protection to existing higher priority transmissions and the safe operation of sensitive medical equipment. The priority users here are utility telemetry transmissions in certain portions of the WMTS band, government run radar sites, and legacy medical telemetry equipment without cognitive radio capability. We provide the first measurements on the complete WMTS spectrum activity at two major hospital locations in the Boston area, and outline an optimization framework that assigns frequency and transmission power jointly in this setting. The article also discusses the current state of the art and the major challenges in the implementation of this new cognitive radio assisted medical telemetry paradigm.
Virologic versus cytologic triage of women with equivocal Pap smears: a meta-analysis of the accuracy to detect high-grade intraepithelial neoplasia.

BACKGROUND The appropriate management of women with minor cytologic lesions in their cervix is unclear. We performed a meta-analysis to assess the accuracy of human papillomavirus (HPV) DNA testing as an alternative to repeat cytology in women who had equivocal results on a previous Pap smear. METHODS Data were extracted from articles published between 1992 and 2002 that contained results of virologic and cytologic testing followed by colposcopically directed biopsy in women with an index smear showing atypical cells of undetermined significance (ASCUS). Fifteen studies were identified in which HPV triage and the histologic outcome (presence or absence of a cervical intraepithelial neoplasia of grade II or worse [CIN2+]) was documented. Nine, seven, and two studies also documented the accuracy of repeat cytology when the cutoff for abnormal cytology was set at a threshold of ASCUS or worse, low-grade squamous intraepithelial lesion (LSIL) or worse, or high-grade squamous intraepithelial lesion (HSIL) or worse, respectively. Random-effects models were used for pooling of accuracy parameters in case of interstudy heterogeneity. Differences in accuracy were assessed by pooling the ratio of the sensitivity (or specificity) of HPV testing to that of repeat cytology. RESULTS The sensitivity and specificity were 84.4% (95% confidence interval [CI] = 77.6% to 91.1%) and 72.9% (95% CI = 62.5% to 83.3%), respectively, for HPV testing overall and 94.8% (95% CI = 92.7% to 96.9%) and 67.3% (95% CI = 58.2% to 76.4%), respectively, for HPV testing in the eight studies that used the Hybrid Capture II assay. Sensitivity and specificity of repeat cytology at a threshold for abnormal cytology of ASCUS or worse was 81.8% (95% CI = 73.5% to 84.3%) and 57.6% (95% CI = 49.5% to 65.7%), respectively. Repeat cytology that used higher cytologic thresholds yielded substantially lower sensitivity but higher specificity than triage with the Hybrid Capture II assay. The ratio of the sensitivity of the Hybrid Capture II assay to that of repeat cytology at a threshold of ASCUS or worse pooled from the four studies that used both triage tests was 1.16 (95% CI = 1.04 to 1.29). The specificity ratio was not statistically different from unity. CONCLUSION The published literature indicates that the Hybrid Capture II assay has improved accuracy (higher sensitivity, similar specificity) than the repeat Pap smear using the threshold of ASCUS for an outcome of CIN2+ among women with equivocal cytologic results. The sensitivity of triage at higher cytologic cutoffs is poor.
Sex Differences in Neural Activation to Facial Expressions Denoting Contempt and Disgust

The facial expression of contempt has been regarded to communicate feelings of moral superiority. Contempt is an emotion that is closely related to disgust, but in contrast to disgust, contempt is inherently interpersonal and hierarchical. The aim of this study was twofold. First, to investigate the hypothesis of preferential amygdala responses to contempt expressions versus disgust. Second, to investigate whether, at a neural level, men would respond stronger to biological signals of interpersonal superiority (e.g., contempt) than women. We performed an experiment using functional magnetic resonance imaging (fMRI), in which participants watched facial expressions of contempt and disgust in addition to neutral expressions. The faces were presented as distractors in an oddball task in which participants had to react to one target face. Facial expressions of contempt and disgust activated a network of brain regions, including prefrontal areas (superior, middle and medial prefrontal gyrus), anterior cingulate, insula, amygdala, parietal cortex, fusiform gyrus, occipital cortex, putamen and thalamus. Contemptuous faces did not elicit stronger amygdala activation than did disgusted expressions. To limit the number of statistical comparisons, we confined our analyses of sex differences to the frontal and temporal lobes. Men displayed stronger brain activation than women to facial expressions of contempt in the medial frontal gyrus, inferior frontal gyrus, and superior temporal gyrus. Conversely, women showed stronger neural responses than men to facial expressions of disgust. In addition, the effect of stimulus sex differed for men versus women. Specifically, women showed stronger responses to male contemptuous faces (as compared to female expressions), in the insula and middle frontal gyrus. Contempt has been conceptualized as signaling perceived moral violations of social hierarchy, whereas disgust would signal violations of physical purity. Thus, our results suggest a neural basis for sex differences in moral sensitivity regarding hierarchy on the one hand and physical purity on the other.
Unpacking (in)formal learning in an academic development programme: a mixed-method social network perspective

How and with whom academics develop and maintain formal and informal networks for reflecting on their teaching practice has received limited attention even though academic development (AD) programmes have become an almost ubiquitous feature of higher education. The primary goal of this mixed-method study is to unpack how 114 academics in an AD programme developed internal (within their programme) and external (outside their programme) learning and teaching relations. A secondary goal is to highlight the affordances of social network analysis (SNA) methods in conjunction with qualitative approaches for academic developers to understand the (in)formal learning processes in their AD programme. The quantitative results indicate that participants maintained 4.84 relations within their AD programme and 3.17 external ties. The qualitative results indicate that most academics developed a range of emotional, academic, and professional support links, which were mostly outside the AD context. Participants needed an outlet to share their feelings, challenges, and frustrations about their teaching and their experiences on the AD programme. These feelings were shared with people they trusted, primarily close friends and colleagues. This study provides a social perspective on the formal and informal relations of AD, and argues that SNA techniques can help academic developers to make these relationships visible.
Fossil water‐penny beetles (Coleoptera: Psephenidae: Eubrianacinae) from the Eocene of Europe, with remarks on their phylogenetic position and biogeography

Abstract: A species of water‐penny beetles is recorded from larval instars from the Middle Eocene Messel pit fossil site in Germany. This species clearly belongs to the psephenid subfamily Eubrianacinae, but its precise systematic affinities remain unclear. It is the second fossil species of this taxon recorded from Europe. The holotype of the first fossil species, Eubrianax vandeli Bertrand and Laurentiaux, 1963, is lost. The high number of fossil specimens from Messel allowed discussion of stratigraphic and spatial occurrence of the eubrianacine species in the Messel pit, but its larval ontogeny could not be unravelled. Because of the high number of fossils and their wide occurrence, it is inferred that the species from Messel gen. sp. 1 was an autochthonous faunal element of the Eocene Lake Messel, which might indicate that some parts of the former Lake Messel had a shore area with stones. The analysis of the phylogenetic position of both Eocene eubrianacine species showed that their phylogenetic placement cannot be resolved because preservational influences limit the evaluation of characters. The historical biogeography of Psephenidae and Eubrianacinae is analysed and discussed. The fossil record shows that psephenid beetles have fossil members occurring outside their current distribution range, so interpretations of their biogeography based only on extant members can be misleading.
From the Inside: Dispatches from a Women's Prison

In November 1999, at Cambridge Crown Court, Ruth Wyner and her co-defendant John Brock were found guilty under the Misuse of Drugs Act. Their 'crime', as charity workers devoted to funning the Wintercomfort hostel for Cambridge's homeless population, was in the eyes of the police to have made insufficient efforts to prevent drug dealing on the premises. Such injustice was astonishing enough, but an even greater shock was the sentence: five years, no less, and the following day Ruth Wyner found herself in Holloway Prison. "From the Inside" is Ruth Wyner's account of her time in a women's prison, first at Holloway and then at Highpoint Prison in Norfolk. She had to serve seven months before the appeal hearing that quashed her sentence - though not her conviction - by which time the "Cambridge Two" campaign had attracted high-profile support from Joan Baez to Tom Stoppard and Jo Brand. It is not only the first full account in years of what life is like in one of Britain's women's prisons - and therefore of sociological interest; it is also the frank and moving story of how one woman - even with the benefits of a loving family, education and mental stability denied to her infinitely more vulnerable fellow inmates - struggled to cope with the unhealthy, dehumanising, incessantly noisy and nerve-jangling daily life of a women's jail.
Hepatoblastoma and hypoplastic kidneys: A new association

Both hepatoblastoma and hypoplastic kidneys are rare in children. A review of all patients with hepatoblastoma treated at our institution between 1993 and 2011 revealed three cases of hepatoblastoma occurring in children with hypoplastic kidneys and significantly impaired renal function. Two patients were treated with doxorubicin‐based therapy without cisplatin. One was treated with carboplatin. The former two are long‐term survivors while the third patient died of sepsis following chemotherapy. This association is unlikely due to chance alone and chemotherapy regimens without cisplatin may be effective in treating these children. Pediatr Blood Cancer 2014; 61:1476–1478. © 2014 Wiley Periodicals, Inc.
QuickCSG: Fast Arbitrary Boolean Combinations of N Solids

QuickCSG computes the result for general N-polyhedron boolean expressions without an intermediate tree of solids. We propose a vertex-centric view of the problem, which simplifies the identification of final geometric contributions, and facilitates its spatial decomposition. The problem is then cast in a single KD-tree exploration, geared toward the result by early pruning of any region of space not contributing to the final surface. We assume strong regularity properties on the input meshes and that they are in general position. This simplifying assumption, in combination with our vertex-centric approach, improves the speed of the approach. Complemented with a task-stealing parallelization, the algorithm achieves breakthrough performance, one to two orders of magnitude speedups with respect to state-of-the-art CPU algorithms, on boolean operations over two to dozens of polyhedra. The algorithm also outperforms GPU implementations with approximate discretizations, while producing an output without redundant facets. Despite the restrictive assumptions on the input, we show the usefulness of QuickCSG for applications with large CSG problems and strong temporal constraints, e.g. modeling for 3D printers, reconstruction from visual hulls and collision detection.
In vivo anabolic effect of strontium on trabecular bone was associated with increased osteoblastogenesis of bone marrow stromal cells

In vitro studies have demonstrated that strontium (Sr) could increase osteogenic differentiation of bone marrow stromal cells (BMSCs). We investigated the in vivo effect of Sr on BMSCs. Thirty‐six female rats were randomly divided into the following groups: sham operated and treated with either vehicle (Sham + Veh) or Sr compound (Sham + Sr) and ovariectomized and treated with either vehicle (OVX + Veh) or Sr compound (OVX + Sr). Vehicle and Sr were orally administrated daily starting immediately after the surgery and continuing for 12 weeks. The anabolic effect of Sr on trabecular bone was determined at the structural and tissue level by microCT and histomorphometry, respectively. Colony formation assays demonstrated that BMSCs exhibited higher osteogenic colony but lower adipogenic colony in Sr‐treated versus Veh‐treated OVX rats. The mRNA level of osteogenic genes was higher, while the mRNA level of adipogenic genes was lower in BMSCs from Sr‐treated versus Veh‐treated Sham and OVX rats. The effect of Sr on rat BMSCs was reproducible in human BMSCs. Taken together, this study suggests that the anabolic effect of Sr on normal or osteoporotic bones is associated with increased osteoblastic differentiation of BMSCs. © 2010 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 28:1208–1214, 2010
Psychosocial outcomes at 18 months after good neurological recovery from aneurysmal subarachnoid haemorrhage

Objectives: To evaluate functioning, 18 months after surgery, of 49 patients with good neurological recovery following aneurysmal subarachnoid haemorrhage (SAH), and to determine the extent of any improvements in disturbances of mood, cognitive functioning, and levels of activity and participation previously observed at 9 month follow up. Methods: SAH patients, matched for age, gender, and occupation with healthy control participants, completely quantitative measures of mood (HADS, FIES, BDI) and activity/participation (BICRO-39 scales), and a brief cognitive assessment battery (verbal fluency, digit span, prose recall). Controls completed the HADS and the BICRO-39. Results: Patients showed some recovery of cognitive functioning, though impairments of prose recall persisted. Anxiety and depression symptoms were higher in patients than in controls, but fewer than 20% scored in the clinical range on any questionnaires except for RIES-Intrusive thoughts (22%); only three showed signs of full blown post-traumatic stress disorder. Almost half showed elevated dependence on others for domestic activities and organisation and abnormally low levels of employment. Very little variance in outcome was predicted by demographic variables, neurological or cognitive impairment, prior life stress, or mood. However, levels of social activity and self-organisation were related to persisting fatigue. Conclusions: The observed decline in intrusive thoughts and avoidance over time is consistent with that seen after life threatening illness or trauma. The persistent reductions in independence and levels of employment may in some cases reflect considered lifestyle adjustments rather than adverse and unwanted changes but in others indicate a need for focused rehabilitation.
Timing matters: the processing of pitch relations

The human central auditory system can automatically extract abstract regularities from a variant auditory input. To this end, temporarily separated events need to be related. This study tested whether the timing between events, falling either within or outside the temporal window of integration (~350 ms), impacts the extraction of abstract feature relations. We utilized tone pairs for which tones within but not across pairs revealed a constant pitch relation (e.g., pitch of second tone of a pair higher than pitch of first tone, while absolute pitch values varied across pairs). We measured the mismatch negativity (MMN; the brain’s error signal to auditory regularity violations) to second tones that rarely violated the pitch relation (e.g., pitch of second tone lower). A Short condition in which tone duration (90 ms) and stimulus onset asynchrony between the tones of a pair were short (110 ms) was compared to two conditions, where this onset asynchrony was long (510 ms). In the Long Gap condition, the tone durations were identical to Short (90 ms), but the silent interval was prolonged by 400 ms. In Long Tone, the duration of the first tone was prolonged by 400 ms, while the silent interval was comparable to Short (20 ms). Results show a frontocentral MMN of comparable amplitude in all conditions. Thus, abstract pitch relations can be extracted even when the within-pair timing exceeds the integration period. Source analyses indicate MMN generators in the supratemporal cortex. Interestingly, they were located more anterior in Long Gap than in Short and Long Tone. Moreover, frontal generator activity was found for Long Gap and Long Tone. Thus, the way in which the system automatically registers irregular abstract pitch relations depends on the timing of the events to be linked. Pending that the current MMN data mirror established abstract rule representations coding the regular pitch relation, neural processes building these templates vary with timing.
Primitive Variable Determination in Conservative Relativistic Magnetohydrodynamic Simulations

In nonrelativistic hydrodynamics and magnetohydrodynamics, conservative integration schemes for the fluid equations of motion are generally employed. The computed quantities, namely, the mass density, (vector) momentum density, and energy density, can readily be converted back into the primitive variables that define the problem, namely, the mass density, (vector) velocity, and thermal pressure. In practical terms, the primitive variables can be “peeled away” from the computed variables. In relativistic problems, however, the appearance of the Lorentz factor in the computed quantities dramatically complicates the problem owing to its near-singular dependence upon relativistic velocities. Conservative integration schemes for the hyperbolic partial differential equations of special relativistic magnetohydrodynamics (RMHD) yield estimates of the five conserved quantities that are related in a highly nonlinear way to the five primitive variables. We also observe that an equivalent set of five nonlinear equati.