Miracle-dz/UniFAR-FTUs huggingface dataset:
Patent Foramen Ovale Closure or Anticoagulation vs. Antiplatelets after Stroke

BACKGROUND Trials of patent foramen ovale (PFO) closure to prevent recurrent stroke have been inconclusive. We investigated whether patients with cryptogenic stroke and echocardiographic features representing risk of stroke would benefit from PFO closure or anticoagulation, as compared with antiplatelet therapy. METHODS In a multicenter, randomized, open‐label trial, we assigned, in a 1:1:1 ratio, patients 16 to 60 years of age who had had a recent stroke attributed to PFO, with an associated atrial septal aneurysm or large interatrial shunt, to transcatheter PFO closure plus long‐term antiplatelet therapy (PFO closure group), antiplatelet therapy alone (antiplatelet‐only group), or oral anticoagulation (anticoagulation group) (randomization group 1). Patients with contraindications to anticoagulants or to PFO closure were randomly assigned to the alternative noncontraindicated treatment or to antiplatelet therapy (randomization groups 2 and 3). The primary outcome was occurrence of stroke. The comparison of PFO closure plus antiplatelet therapy with antiplatelet therapy alone was performed with combined data from randomization groups 1 and 2, and the comparison of oral anticoagulation with antiplatelet therapy alone was performed with combined data from randomization groups 1 and 3. RESULTS A total of 663 patients underwent randomization and were followed for a mean (±SD) of 5.3±2.0 years. In the analysis of randomization groups 1 and 2, no stroke occurred among the 238 patients in the PFO closure group, whereas stroke occurred in 14 of the 235 patients in the antiplatelet‐only group (hazard ratio, 0.03; 95% confidence interval, 0 to 0.26; P<0.001). Procedural complications from PFO closure occurred in 14 patients (5.9%). The rate of atrial fibrillation was higher in the PFO closure group than in the antiplatelet‐only group (4.6% vs. 0.9%, P=0.02). The number of serious adverse events did not differ significantly between the treatment groups (P=0.56). In the analysis of randomization groups 1 and 3, stroke occurred in 3 of 187 patients assigned to oral anticoagulants and in 7 of 174 patients assigned to antiplatelet therapy alone. CONCLUSIONS Among patients who had had a recent cryptogenic stroke attributed to PFO with an associated atrial septal aneurysm or large interatrial shunt, the rate of stroke recurrence was lower among those assigned to PFO closure combined with antiplatelet therapy than among those assigned to antiplatelet therapy alone. PFO closure was associated with an increased risk of atrial fibrillation. (Funded by the French Ministry of Health; CLOSE ClinicalTrials.gov number, NCT00562289.)
The Intraoral Ultrasonography in Dentistry

Ultrasonography (USG) is a diagnostic method that the ultrasonic image is created by ultrahigh-frequency sound waves, which have an acoustic frequency above the threshold of human hearing. Compared to other medical imaging methods, USG has several advantages of being real time, portable, inexpensive, radiation free, and noninvasive. In the medicine, most of the USG applications are transcutaneous. However, intraoral USG has been a relatively rare application, it has recently been drawing more interest. Intraoral USG is also used in dentistry for examining the salivary glands and ducts, as well as the mouth floor, the buccal, labial, and palatal mucosa, the tongue, periodontal tissues, and periapical lesions. The main purpose of this review is to provide detailed information about intraoral USG applications in dentistry.
Chinese Open Relation Extraction and Knowledge Base Establishment

Named entity relation extraction is an important subject in the field of information extraction. Although many English extractors have achieved reasonable performance, an effective system for Chinese relation extraction remains undeveloped due to the lack of Chinese annotation corpora and the specificity of Chinese linguistics. Here, we summarize three kinds of unique but common phenomena in Chinese linguistics. In this article, we investigate unsupervised linguistics-based Chinese open relation extraction (ORE), which can automatically discover arbitrary relations without any manually labeled datasets, and research the establishment of a large-scale corpus. By mapping the entity relations into dependency-trees and considering the unique Chinese linguistic characteristics, we propose a novel unsupervised Chinese ORE model based on Dependency Semantic Normal Forms (DSNFs). This model imposes no restrictions on the relative positions among entities and relationships and achieves a high yield by extracting relations mediated by verbs or nouns and processing the parallel clauses. Empirical results from our model demonstrate the effectiveness of this method, which obtains stable performance on four heterogeneous datasets and achieves better precision and recall in comparison with several Chinese ORE systems. Furthermore, a large-scale knowledge base of entity and relation, called COER, is established and published by applying our method to web text, which conquers the trouble of lack of Chinese corpora.
Miller's Pyramid and Core Competency Assessment: A Study in Relationship Construct Validity

Introduction: Continuous professional development relies on the link between performance and an educational process aimed at improving knowledge and skill. One of the most broadly used frameworks for assessing skills is Miller's Pyramid. This Pyramid has a series of levels of achievement beginning with knowledge (at the base) and ending with routine application in the clinical setting. Methods: The purpose of this study was to determine the degree of convergence of two measurement methods, one based on Miller's framework, the second using the Accreditation Council for Graduate Medical Education/American Board of Medical Specialties (ACGME/ABMS) Core Competency framework. The data were gathered from the faculty of a large, Midwestern regional health care provider and hospital system. Data from 264 respondents were studied. The 360° data were from raters of physicians holding supervisory roles in the organization. The scale items were taken from an instrument that has been validated for both structure and known group prediction. Results: The Miller scale was purposely built for this application. The questions were designed to describe each level of the model. The Miller scale was reduced to a single dimension. This result was then regressed on the items from the 360° item ratings. Results of a multivariate analysis of variance isolated a significant relationship between the Miller's Pyramid score and the competency items (P < 0.001). Discussion: These findings demonstrate a relationship between measures based on Miller's framework and behavioral measures based on the ABMS/ACGME core competencies. Equally important is the finding that while they are related they are not identical. These findings have implications for continuous professional development programing design.
Acute Down-regulation of BDNF Signaling Does Not Replicate Exacerbated Amyloid-β Levels and Cognitive Impairment Induced by Cholinergic Basal Forebrain Lesion

Degeneration of basal forebrain cholinergic neurons (BFCNs) precedes hippocampal degeneration and pathological amyloid-beta (Aβ) accumulation, and underpins the development of cognitive dysfunction in sporadic Alzheimer’s disease (AD). We hypothesized that degeneration of BFCNs causes a decrease in neurotrophin levels in innervated brain areas, which in turn promotes the development of Aβ pathology and cognitive impairment. Here we show that lesion of septo-hippocampal BFCNs in a pre-symptomatic transgenic amyloid AD mouse model (APP/PS1 mice) increases soluble Aβ levels in the hippocampus, and induces cognitive deficits in a spatial memory task that are not seen in either unlesioned APP/PS1 or non-transgenic littermate control mice. Furthermore, the BFCN lesion results in decreased levels of brain-derived neurotrophic factor (BDNF). However, viral knockdown of neuronal BDNF in the hippocampus of APP/PS1 mice (in the absence of BFCN loss) neither increased the level of Aβ nor caused cognitive deficits. These results suggest that the cognitive decline and Aβ pathology induced by BFCN loss occur independent of dysfunctional neuronal BDNF signaling, and may therefore be directly underpinned by reduced cholinergic neurotransmission.
Involvement of Nrf2 in Ocular Diseases

The human body harbors within it an intricate and delicate balance between oxidants and antioxidants. Any disruption in this checks-and-balances system can lead to harmful consequences in various organs and tissues, such as the eye. This review focuses on the effects of oxidative stress and the role of a particular antioxidant system—the Keap1-Nrf2-ARE pathway—on ocular diseases, specifically age-related macular degeneration, cataracts, diabetic retinopathy, and glaucoma. Together, they are the major causes of blindness in the world.
Multiple Disease Risk Assessment With Uniform Model Based on Medical Clinical Notes

Unstructured clinical medical text, as an important part of the electronic health records, is characterized by large quantities and can store substantial disease-related information of patients. Currently, the disease risk assessment model based on the analysis of clinical medical text designs relevant characteristics aiming at certain diseases, and different characteristics are identified from the text using different methods. In this way, changes of disease performance characteristics are difficult to adapt. Furthermore, it is hard to use the risk assessment model in other disease applications. As a result, this paper establishes the universal disease risk assessment model using the data of clinical medical text, conducts the independent study, and extracts disease characteristics from substantial historical data to avoid the limitations designing disease characteristics. First, this paper analyzes the medial clinical text to determine the contents related to the disease characteristics of patients. Second, learn the representation of clinical text with unsupervised learning methods, and study and extract the disease characteristics from the substantial historical data of patients in the convolutional neural network to assess disease risks. Finally, make a contrast experiment of disease risk assessment using the clinical text data of patients with cerebral infarction, patients with pulmonary infection, and patients with coronary atherosclerotic heart disease from the data of a second grade-A hospital in China and related methods. The experiments show that the approach proposed in this paper achieves the disease risk assessment for different diseases with the same structure.
Kawasaki disease in infants below 6 months: a clinical conundrum?

Kawasaki disease (KD) is a medium vessel vasculitis of childhood. In infancy KD is often characterized by incomplete and atypical forms. There is paucity of literature on KD in children below 6 months and there are no data from any developing country. This study defines the profile of children with KD below 6 months at our centre.
Full Exploitation of Lightweight Design Potentials by Generating Pronounced Compressive Residual Stress Fields with Hydraulic Autofrettage

Internally pressurized components in hydraulic systems are subjected to high mechanical stresses. In case of dynamic pressure profiles this may lead to fatigue and hence a limited lifetime. This is particularly the case for fuel injection systems in combustion engines. Components of diesel injection systems in automobiles are popular examples for these demands. They have to withstand pressures of 2,200 bar and higher for at least 250,000 km. The increasing usage of high-strength materials and higher wall thicknesses will lead to a dead end as the weight and the complex manufacturing will tie up costs and resources. Autofrettage is a manufacturing process with high potential for the lightweight design of highly stressed hydraulic components. By considering the same wall thickness and applying optimal parameters, the fatigue strength may be increased by a factor of 3.5. If transferred to lightweight concepts wall thickness reductions as well as cost and resource savings by more than 45 % may be realized. However, from the manufacturing perspective the Autofrettage process poses some challenges. This paper presents results from Finite Element simulations and experiments and discusses the interaction between manufacturing processes with respect to residual stresses and deformations. The scientific findings may be used to tear down barriers in the application of Autofrettage and to optimize process chain layouts. It also serves to make a significant contribution to weight reduction in car manufacturing and other high performance hydraulic applications. Abbreviations: AF : Autofrettage; AFM : Abrasive Flow Machining; ECM : Electro-Chemical Machining; FEA : Finite Element Analysis; K-ratio : outer to inner radius ratio; L = length of the cylinder (mm); pAF : Autofrettage pressure (bar); pWP : working pressure (bar); piY : pressure to initiate yielding at the bore (bar); Ra : roughness average (μm); Rz : average maximum height of the roughness profile (μm); RPM : Revolutions Per Minute (1/min.); ri : inner radius (mm); ro : outer radius (mm); ρ : density (kg/dm3); σVM : von Mises equivalent stress (MPa); σy : yield stress (MPa); σt : tensile stress (MPa); σY : yield strength (MPa); SF : Safety Factor;
Neonatal Outcomes by Mode of Delivery in Preterm Birth

Abstract Objective We set out to test the hypothesis that infants born vaginally at ≤ 30 weeks gestation have less respiratory distress syndrome (RDS) than those born by cesarean delivery. Study Design We conducted a retrospective cohort study of 652 infants born between 24 and 30 6/7 weeks gestation from March 31, 1996 to May 31, 2014. Comparisons of neonatal outcomes by intended and actual mode of delivery were made using chi-square and t-tests (α = 0.05). Multiple logistic regression was performed to control for confounding variables. Results Neonates born by cesarean delivery were more likely to have RDS (odds ratio [OR], 1.79; 95% confidence interval [CI], 1.10–2.90), require intubation (OR, 1.80; 95% CI, 1.12–2.88), and have longer neonatal intensive care unit stay (70.0 ± 37.1 vs. 57.3 ± 40.1 days, p = 0.02). Conclusion Compared with cesarean delivery, vaginal delivery is associated with a significant reduction in RDS among infants born at ≤ 30 weeks gestation.
Food Literacy at Secondary Schools in Australia.

BACKGROUND Food literacy can encourage adolescents to develop healthy dietary patterns. This study examined home economics teachers' (HET) perspectives of the importance, curriculum, self-efficacy, and food environments regarding food literacy in secondary schools in Australia. METHODS A 20-item cross-sectional survey was completed by 205 HETs. The survey focused on the importance of aspects of food literacy, HETs' self-efficacy, and attitudes toward food literacy and schools' food environments. Data were analyzed descriptively, and associations between participants' demographic characteristics and perceptions were investigated by chi-square analyses. RESULTS HETs rated aspects of food literacy including preparing and cooking food, knowing about healthy foods and food safety and hygiene practices as very important. They indicated animal welfare, where food comes from, and plan and manage time for food shopping to be the least important aspects of food literacy. HETs reported that students' involvement in food literacy activities resulted in healthier diets and improved food practices, but the schools' food environments are not comprehensively supportive of food literacy. CONCLUSIONS HETs report that food literacy is very important for adolescents to learn. The focus is more on microaspects in comparison to macroaspects of food literacy. Schools' food environments are ideally positioned to shape dietary intake of adolescents but their potential is not being realized.
Pleural Effusion: Diagnosis and Management

Pleural effusion is defined as an accumulation of fluid in the pleural space in excess of 15 to 20mls. The aetiology for the development of a pleural effusion includes changes in hydrostatic or colloid-osmotic pressure of pleural and pulmonary capillaries, changes in pleural vascular permeability and impaired lymphatic drainage. About 5% to 12% of patients referred for emergency medical treatment are diagnosed with a pleural effusion, making it a common finding on hospital admission. The excess of pleural fluid may be triggered by pleuro-pulmonary infection, malignancy, or conditions of cardiac, renal or hepatic origin. Subsequent management is guided mainly by aetiology and to a lesser degree by symptoms. This paper provides a review of pathophysiology, diagnosis and management of the condition and addresses specific issues regarding the perioperative care of these patients.
On the Unhappiness of Software Developers

The happy-productive worker thesis states that happy workers are more productive. Recent research in software engineering supports the thesis, and the ideal of flourishing happiness among software developers is often expressed among industry practitioners. However, the literature suggests that a cost-effective way to foster happiness and productivity among workers could be to limit unhappiness. Psychological disorders such as job burnout and anxiety could also be reduced by limiting the negative experiences of software developers. Simultaneously, a baseline assessment of (un)happiness and knowledge about how developers experience it are missing. In this paper, we broaden the understanding of unhappiness among software developers in terms of (1) the software developer population distribution of (un)happiness, and (2) the causes of unhappiness while developing software. We conducted a large-scale quantitative and qualitative survey, incorporating a psychometrically validated instrument for measuring (un)happiness, with 2 220 developers, yielding a rich and balanced sample of 1318 complete responses. Our results indicate that software developers are a slightly happy population, but the need for limiting the unhappiness of developers remains. We also identified 219 factors representing causes of unhappiness while developing software. Our results, which are available as open data, can act as guidelines for practitioners in management positions and developers in general for fostering happiness on the job. We suggest considering happiness in future studies of both human and technical aspects in software engineering.
Aberrant nigral diffusion in Parkinson's disease: A longitudinal diffusion tensor imaging study

Measuring microstructure alterations with diffusion tensor imaging in PD is potentially a valuable tool to use as a biomarker for early diagnosis and to track disease progression. Previous studies have reported a specific decrease of nigral fractional anisotropy in PD. However, to date the effect of disease progression on nigral or striatal diffusion indices has not been fully explored.
The role of executive control in resolving grammatical number conflict in sentence comprehension

In sentences with a complex subject noun phrase, like “The key to the cabinets is lost”, the grammatical number of the head noun (key) may be the same or different from that of the modifier noun phrase (cabinets). When the number is the same, comprehension is usually easier than when it is different. Grammatical number computation may occur while processing the modifier noun (integration phase) or while processing the verb (checking phase). We investigated at which phase number conflict and plausibility of the modifier noun as subject for the verb affect processing, and we imposed a gaze-contingent tone discrimination task in either phase to test whether number computation involves executive control. At both phases, gaze durations were longer when a concurrent tone task was present. Additionally, at the integration phase, gaze durations were longer under number conflict, and this effect was enhanced by the presence of a tone task, whereas no effects of plausibility of the modifier were observed. The finding that the effect of number match was larger under load shows that computation of the grammatical number of the complex noun phrase requires executive control in the integration phase, but not in the checking phase.
DIETARY SURVEYS AND NUTRITIONAL EPIDEMIOLOGY High sodium:potassium intake ratio increases the risk for all-cause mortality: the REasons for Geographic And Racial Differences in Stroke (REGARDS) study JOURNAL OF NUTRITIONAL SCIENCE

Increased dietary Na intake and decreased dietary K intake are associated with higher blood pressure. It is not known whether the dietary Na:K ratio is associated with all-cause mortality or stroke incidence and whether this relationship varies according to race. Between 2003 and 2007, the REasons for Geographic And Racial Differences in Stroke (REGARDS) cohort enrolled 30 239 black and white Americans aged 45 years or older. Diet was assessed using the Block 98 FFQ and was available on 21 374 participants. The Na:K ratio was modelled in race- and sex-speci ﬁ c quintiles for all analyses, with the lowest quintile (Q1) as the reference group. Data on other covariates were collected using both an in-home assessment and telephone interviews. We identi ﬁ ed 1779 deaths and 363 strokes over a mean of 4 · 9 years. We used Cox proportional hazards models to obtain multivariable-adjusted hazard ratios (HR). In the highest quintile (Q5), a high Na:K ratio was associated with all-cause mortality (Q5 v . Q1 for whites: HR 1 · 22; 95 % CI 1 · 00, 1 · 47, P for trend = 0 · 084; for blacks: HR 1 · 36; 95 % CI 1 · 04, 1 · 77, P for trend = 0 · 028). A high Na:K ratio was not signi ﬁ cantly associated with stroke in whites (HR 1 · 29; 95 % CI 0 · 88, 1 · 90) or blacks (HR 1 · 39; 95 % CI 0 · 78, 2 · 48), partly because of the low number of stroke events. In the REGARDS study, a high Na:K ratio was associated with all-cause mortality and there was a suggestive association between the Na:K ratio and stroke. These data support the policies targeted at reduction of Na from the food supply and recommendations to increase K intake.
>1.3-Tb/s VCSEL-Based On-Board Parallel-Optical Transceiver Module for High-Density Optical Interconnects

This paper gives a detailed description of a >1.3-Tb/s VCSEL-based on-board parallel-optical transceiver module for high-density optical interconnects. The optical module integrates a 28-Gb/s × 24-channel transmitter and receiver into one package with a 1-in2 footprint, thereby yielding a data rate density as high as 1.34 Tb/s/in2. A unique module design is developed to utilize the whole top surface for thermal dissipation and the bottom surface for optical and electrical interfaces. The heat dissipation characteristics are studied in simulations and experiments. A test system of 24-channel optical loop-back link is built to evaluate the performance when operating all 24 channels by 28.05-Gb/s 231–1 PRBS bit streams simultaneously. With a total power consumption of 9.1 W, the optical module can be operated within the operating case temperature under a practical air cooling condition. When operating all 24 channels simultaneously, a total jitter margin at BER of 10–12 is larger than 0.4 U.I. at a monitor channel. The measured jitter margin is consistent regardless of any channel operation.