Miracle-dz/UniFAR-FTUs huggingface dataset:
Language comprehension and regional cerebral defects in frontotemporal degeneration and Alzheimer's disease

We related profiles of language comprehension difficulty to patterns of reduced cerebral functioning obtained with high-resolution single photon emission computed tomography (SPECT) in patients with neurodegenerative conditions. We found different patterns of reduced relative cerebral perfusion in patients with frontotemporal degeneration (FD) and patients with Alzheimer's disease (AD). Cognitive assessments also showed different patterns of impaired comprehension in patients with FD and patients with AD. Grammatical comprehension difficulty in FD correlated with relative cerebral perfusion in left frontal and anterior temporal brain regions; impaired semantic processing in AD correlated with relative cerebral perfusion in inferior parietal and superior temporal regions of the left hemisphere. These findings are consistent with the hypothesis that a neural network distributed throughout the left hemisphere subserving different aspects of language comprehension, rather than a single brain region, is responsible for understanding language.
The initial conditions of young globular clusters in the Large Magellanic Cloud

N-body simulations are used to model the early evolution of globular clusters. These simulations include residual gas which was not turned into stars, which is expelled from the globular cluster by the actions of massive (> 8 M0 ) stars. The results of these simulations are compared with observations of eight LMC globular clusters less than 100 Myr old. These observations are used to constrain the initial conditions that may have produced these clusters. It is found that the observations can be accounted for in a model where the globular clusters form from proto-cluster clouds similar to Plummer models with length-scales in the range 1 < Rs/pc < 3 where the star formation efficiency varies between 25 and 60 per cent. Using these derived initial conditions the survivability of these clusters in both the Galaxy and the LMC is assessed. If the slope of the initial mass function is around a = 2.35 then two or three of these clusters may be able to survive for a Hubble time even in the Galactic halo. In this case these clusters may represent young versions of the Galactic globular cluster popUlation which was severely depleted by the destruction of many of its original members. In the case where a = 1.50, however, none of these clusters would be expected to survive for more than a few Gyr at most, even within the LMC.
Status and Prospects

1 Abstract The KADoNiS (Karlsruhe Astrophysical Database of Nucleosynthesis in Stars) project is an astrophysical online database for cross sections relevant for nucleosynthesis in the s process and the γ process. The s-process database (www.kadonis.org) was started in 2005 and is presently facing its 4th update (KADoNiS v1.0). The γ-process database (KADoNiS-p, www.kadonis.org/pprocess) was recently revised and re-launched in March 2013. Both databases are compilations for experimental cross sections with relevance to heavy ion nucleosynthesis. For the s process recommended Maxwellian averaged cross sections for kT = 5-100 keV are given for more than 360 isotopes between 1 H and 210 Bi. For the γ-process database 70 Ge and 209 Bi in or close to the respective Gamow window were collected and can be compared to theoretical predictions. The aim of both databases is a quick and user-friendly access to the available data in the astrophysically relevant energy regions.
Comparative Genome Analyses of Vibrio anguillarum Strains Reveal a Link with Pathogenicity Traits

Comparative genome analysis of strains of a pathogenic bacterial species can be a powerful tool to discover acquisition of mobile genetic elements related to virulence. Here, we compared 28 V. anguillarum strains that differed in virulence in fish larval models. By pan-genome analyses, we found that six of nine highly virulent strains had a unique core and accessory genome. In contrast, V. anguillarum strains that were medium to nonvirulent had low genomic diversity. Integration of genomic and phenotypic features provides insights into the evolution of V. anguillarum and can also be important for survey and diagnostic purposes. ABSTRACT Vibrio anguillarum is a marine bacterium that can cause vibriosis in many fish and shellfish species, leading to high mortalities and economic losses in aquaculture. Although putative virulence factors have been identified, the mechanism of pathogenesis of V. anguillarum is not fully understood. Here, we analyzed whole-genome sequences of a collection of V. anguillarum strains and compared them to virulence of the strains as determined in larval challenge assays. Previously identified virulence factors were globally distributed among the strains, with some genetic diversity. However, the pan-genome revealed that six out of nine high-virulence strains possessed a unique accessory genome that was attributed to pathogenic genomic islands, prophage-like elements, virulence factors, and a new set of gene clusters involved in biosynthesis, modification, and transport of polysaccharides. In contrast, V. anguillarum strains that were medium to nonvirulent had a high degree of genomic homogeneity. Finally, we found that a phylogeny based on the core genomes clustered the strains with moderate to no virulence, while six out of nine high-virulence strains represented phylogenetically separate clusters. Hence, we suggest a link between genotype and virulence characteristics of Vibrio anguillarum, which can be used to unravel the molecular evolution of V. anguillarum and can also be important from survey and diagnostic perspectives. IMPORTANCE Comparative genome analysis of strains of a pathogenic bacterial species can be a powerful tool to discover acquisition of mobile genetic elements related to virulence. Here, we compared 28 V. anguillarum strains that differed in virulence in fish larval models. By pan-genome analyses, we found that six of nine highly virulent strains had a unique core and accessory genome. In contrast, V. anguillarum strains that were medium to nonvirulent had low genomic diversity. Integration of genomic and phenotypic features provides insights into the evolution of V. anguillarum and can also be important for survey and diagnostic purposes.
Why Stocks May Disappoint *

Finance Association meeting and the Park City Western Finance Association meeting. We especially thank two anonymous referees whose comments greatly improved the paper. A detailed technical appendix is available at Abstract We provide a formal treatment of both static and dynamic portfolio choice using the Disappointment Aversion preferences of Gul (1991), which imply asymmetric aversion to gains versus losses. Our dynamic formulation nests the standard CRRA asset allocation problem as a special case. Using realistic data generating processes, we find reasonable equity portfolio allocations for disappointment averse investors with utility functions exhibiting low curvature. Moderate variation in parameters can robustly generate substantial cross-sectional variation in portfolio holdings, including optimal non-participation in the stock market.
COHERENCE AND CORRESPONDENCE IN THE NETWORK DYNAMICS OF BELIEF SUITES

ABSTRACT Coherence and correspondence are classical contenders as theories of truth. In this paper we examine them instead as interacting factors in the dynamics of belief across epistemic networks. We construct an agent-based model of network contact in which agents are characterized not in terms of single beliefs but in terms of internal belief suites. Individuals update elements of their belief suites on input from other agents in order both to maximize internal belief coherence and to incorporate ‘trickled in’ elements of truth as correspondence. Results, though often intuitive, prove more complex than in simpler models (Hegselmann and Krause 2002, 2006; Grim et al. 2015). The optimistic finding is that pressures toward internal coherence can exploit and expand on small elements of truth as correspondence is introduced into epistemic networks. Less optimistic results show that pressures for coherence can also work directly against the incorporation of truth, particularly when coherence is established first and new data are introduced later.
PAPP-A proteolytic activity enhances IGF bioactivity in ascites from women with ovarian carcinoma

Pregnancy-associated plasma protein-A (PAPP-A) stimulates insulin-like growth factor (IGF) action through proteolysis of IGF-binding protein (IGFBP)-4. In experimental animals, PAPP-A accelerates ovarian tumor growth by this mechanism. To investigate the effect of PAPP-A in humans, we compared serum and ascites from 22 women with ovarian carcinoma. We found that ascites contained 46-fold higher PAPP-A levels as compared to serum (P < 0.001). The majority (80%) of PAPP-A was enzymatically active. This is supported by the finding that ascites contained more cleaved than intact IGFBP-4 (P < 0.03). Ascites was more potent than serum in activating the IGF-I receptor (IGF-IR) in vitro (+31%, P < 0.05); in 8 of 22 patients by more than two-fold. In contrast, ascites contained similar levels of immunoreactive IGF-I, and lower levels of IGF-II (P < 0.001). Immunohistochemistry demonstrated the presence of IGF-IR in all but one tumor, whereas all tumors expressed PAPP-A, IGFBP-4, IGF-I and IGF-II. Addition of recombinant PAPP-A to ascites increased the cleavage of IGFBP-4 and enhanced IGF-IR activation (P < 0.05). In conclusion, human ovarian tumors express PAPP-A, IGFBP-4 and IGFs and these proteins are also present in ascites. We suggest that both soluble PAPP-A in ascites and tissue-associated PAPP-A serve to increase IGF bioactivity and, thereby, to stimulate IGF-IR-mediated tumor growth.
Asymmetry and time span of experimentally induced mood

This study describes a procedure for experimentally inducing positive and negative mood states in the laboratory. Following Seibert and Ellis' procedure (1991), our purpose was to induce sad or happy moods in subjects having read self-referencing sentences. The results point to the existence of an emotional asymmetry, namely, a happy mood is more short-lived than a sad mood. This result is discussed in terms of a difference in the cognitive effort involved in emotional situations resulting either from a sad or from a happy feeling.
RCUBE: Parallel Multi-Dimensional RolaP Indexing 1

This article addresses the query performance issue for Relational OLAP (ROLAP) datacubes. We present RCUBE, a distributed multidimensional ROLAP indexing scheme which is practical to implement, requires only a small communication volume, and is fully adapted to distributed disks. Our solution is efficient for spatial searches in high dimensions and scalable in terms of data sizes, dimensions, and number of processors. Our method is also incrementally maintainable. Using “surrogate” group-bys, it allows for the efficient processing of arbitrary OLAP queries on partial cubes, where not all of the group-bys have been materialized. Our experiments with RCUBE show that the ROLAP advantage of better scalability, in comparison to MOLAP, can be maintained while providing a fast and flexible index for OLAP queries.
Technical and Patient Performance Using a Virtual Reality-Integrated Telerehabilitation System: Preliminary Finding

Telerehabilitation is the provision of rehabilitation services at a distance by a therapist at a remote location. Integration with virtual reality (VR) is a relatively new addition to this field. This paper describes the technical and patient performance of a telerehabilitation application the remote console (ReCon) that is integrated with a VR system. The VR system consists of the Rutgers Ankle prototype robot, a local PC which is connected with a remote PC connected over the Internet. Six individuals in the chronic phase poststroke participated in a four week training program. They used the robot to interact with two VR simulations, while the therapist was in the same room during the first three weeks or in another room during the fourth week. Technical and patient performance was assessed in the transition from the third to the fourth week of training. Technical performance of the system was assessed based on bandwidth and lag of message transmission, which were found to be suitable for clinic-to-clinic communication. Patient performance (in terms of accuracy of ankle movement, exercise duration and training efficiency, mechanical power of the ankle, and number of repetitions) did not decrease during telerehabilitation in the fourth week. These preliminary findings over a short telerehabilitation intervention support the feasibility of remote monitoring of VR-based telerehabilitation without adverse effects on patient performance
The influence of familiarity among group members and extraversion on verbal interaction in proximate GSS sessions

Although computer-mediated communication (CMC) is popular, past research shows that face-to-face (FTF) interaction is also important in CMC environments. The question is what are the accelerators for FTF interaction in CMC scenarios? A literature review finds the accelerators of familiarity among group members and personality factors related to E/I (extraversion/introversion) important factors to consider in FTF interaction. The focus, therefore, of this study is on proximate group support system (GSS) environments that have both CMC and FTF interactions. The objective of the study is to reveal the impacts of familiarity among group members and E/I on verbal interaction in GSS sessions. A proposed causal model, in which verbal and GSS interactions are mediators between the combinations of "group member familiarity & E/I factors," and "meeting satisfaction & group cohesion," is tested. To examine the model, eight proximate GSS sessions are observed and data are gathered using questionnaires from 59 participants. The data are then analyzed using path analysis. Results show that verbal and GSS interactions do not positively mediate between the combinations of "group member's familiarity & E/I factors," and "meeting satisfaction & group cohesion. " This means that verbal interaction is independent from personal factors such as familiarity or E/I and, probably, meeting management factors are important to accelerate verbal interaction among participants. Implications of these findings are discussed within the context of virtual and/or asynchronous meetings.
Notch1 Signaling in Pyramidal Neurons Regulates Synaptic Connectivity and Experience-Dependent Modifications of Acuity in the Visual Cortex

How the visual cortex responds to specific stimuli is strongly influenced by visual experience during development. Monocular deprivation, for example, changes the likelihood of neurons in the visual cortex to respond to input from the deprived eye and reduces its visual acuity. Because these functional changes are accompanied by extensive reorganization of neurite morphology and dendritic spine turnover, genes regulating neuronal morphology are likely to be involved in visual plasticity. In recent years, Notch1 has been shown to mediate contact inhibition of neurite outgrowth in postmitotic neurons and implicated in the pathogenesis of various degenerative diseases of the CNS. Here, we provide the first evidence for the involvement of neuronal Notch1 signaling in synaptic morphology and plasticity in the visual cortex. By making use of the Cre/Lox system, we expressed an active form of Notch1 in cortical pyramidal neurons several weeks after birth. We show that neuronal Notch1 signals reduce dendritic spine and filopodia densities in a cell-autonomous manner and limit long-term potentiation in the visual cortex. After monocular deprivation, these effects of Notch1 activity predominantly affect responses to visual stimuli with higher spatial frequencies. This results in an enhanced effect of monocular deprivation on visual acuity.
Conditional clauses in novice academic English: A comparison of Norwegian learners and native speakers

This study concerns the syntactic, semantic and pragmatic features of conditional clauses in novice academic English. The material comes from the VESPA corpus, representing Norwegian advanced learners of English, and the BAWE corpus, representing English L1 students in British universities. The learners are shown to overuse conditionals in general, but to mostly master their syntactic and semantic features. The overuse may be associated with the interpersonal functions of conditionals. The epistemic use in argument building is more apparent among the native speakers.
The Novel Caspase-3 Substrate Gap43 is Involved in AMPA Receptor Endocytosis and Long-Term Depression*

The cysteine protease caspase-3, best known as an executioner of cell death in apoptosis, also plays a non-apoptotic role in N-methyl-d-aspartate receptor-dependent long-term depression of synaptic transmission (NMDAR-LTD) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor endocytosis in neurons. The mechanism by which caspase-3 regulates LTD and AMPA receptor endocytosis, however, remains unclear. Here, we addressed this question by using an enzymatic N-terminal peptide enrichment method and mass spectrometry to identify caspase-3 substrates in neurons. Of the many candidates revealed by this proteomic study, we have confirmed BASP1, Dbn1, and Gap43 as true caspase-3 substrates. Moreover, in hippocampal neurons, Gap43 mutants deficient in caspase-3 cleavage inhibit AMPA receptor endocytosis and LTD. We further demonstrated that Gap43, a protein well-known for its functions in axons, is also localized at postsynaptic sites. Our study has identified Gap43 as a key caspase-3 substrate involved in LTD and AMPA receptor endocytosis, uncovered a novel postsynaptic function for Gap43 and provided new insights into how long-term synaptic depression is induced.
Ownership Structure and Risk in Publicly Held and Privately Owned Banks

Using detailed ownership data for a sample of European commercial banks, we analyze the link between ownership structure and risk in both privately owned and publicly held banks. We consider five categories of shareholders that are specific to our dataset. We find that ownership structure is significant in explaining risk differences but mainly for privately owned banks. A higher equity stake of either individuals/families or banking institutions is associated with a decrease in asset risk and default risk. In addition, institutional investors and non-financial companies impose the riskiest strategies when they hold higher stakes. For publicly held banks, changes in ownership structure do not affect risk taking. Market forces seem to align the risk-taking behavior of publicly held banks, such that ownership structure is no longer a determinant in explaining risk differences. However, higher stakes of banking institutions in publicly held banks are associated with lower credit and default risk.
Oocyte morphology and transcriptional silencing in relation to chromatin remodeling during the final phases of bovine oocyte growth

The complexity of the events which orchestrate mammalian oocyte growth and ultimate acquisition of developmental competence is still unclear and under continuous investigation. Starting from the observation that germinal vesicle (GV) bovine oocytes exhibit different patterns of chromatin configuration (from GV0 to GV3), the present study aimed at analyzing the morphology of the nuclear and the cytoplasmic compartments and to determine the total transcriptional activity of immature oocytes sorted on the basis of their chromatin configuration. The oocyte morphology was analyzed by light microscopy (LM) on semi‐thin sections and transmission electron microscopy, and the global transcriptional activity was analyzed by H3‐Uridine incorporation and subsequent autoradiography on semi‐thin sections. LM confirmed the increase in chromatin condensation from GV0 to GV3. Ultrastructurally, the nucleolus was fibrillo granular at GV0 while the other stages displayed an electron‐dense fibrillar sphere with the remnant of a fibrillar center on the surface. Organelles were dispersed in the cytoplasm at GV0 while at GV1 and GV2 most of them were homogenously distributed in the oocyte cortex. At GV3 most organelles were found in clusters in the oocyte cortex. Typical features of completion of the oocyte growth phase, like undulation of the nuclear envelope and reduction of the size of Golgi complex were found at GV2 and GV3. Moreover, GV3 oocytes presented cortical granules that displayed varying degrees of degeneration. Autoradiographic labeling showed that oocytes with GV0 configuration exhibited high level of RNA synthesis, GV1 and GV2 stages showed a remarkable decrease of transcription, and the acquisition of GV3 configuration was associated with global repression of transcriptional activity. Our findings suggest a temporal relationship between the chromatin remodeling process and the main morpho‐functional events that characterize the final growth phase in bovine oocyte. Mol. Reprod. Dev. 75: 915–924, 2008. © 2007 Wiley‐Liss, Inc.
Identification of MicroRNAs as Potential Prognostic Markers in Ependymoma

Introduction We have examined expression of microRNAs (miRNAs) in ependymomas to identify molecular markers of value for clinical management. miRNAs are non-coding RNAs that can block mRNA translation and affect mRNA stability. Changes in the expression of miRNAs have been correlated with many human cancers. Materials and Methods We have utilized TaqMan Low Density Arrays to evaluate the expression of 365 miRNAs in ependymomas and normal brain tissue. We first demonstrated the similarity of expression profiles of paired frozen tissue (FT) and paraffin-embedded specimens (FFPE). We compared the miRNA expression profiles of 34 FFPE ependymoma samples with 8 microdissected normal brain tissue specimens enriched for ependymal cells. miRNA expression profiles were then correlated with tumor location, histology and other clinicopathological features. Results We have identified miRNAs that are over-expressed in ependymomas, such as miR-135a and miR-17-5p, and down-regulated, such as miR-383 and miR-485-5p. We have also uncovered associations between expression of specific miRNAs which portend a worse prognosis. For example, we have identified a cluster of miRNAs on human chromosome 14q32 that is associated with time to relapse. We also found that miR-203 is an independent marker for relapse compared to the parameters that are currently used. Additionally, we have identified three miRNAs (let-7d, miR-596 and miR-367) that strongly correlate to overall survival. Conclusion We have identified miRNAs that are differentially expressed in ependymomas compared with normal ependymal tissue. We have also uncovered significant associations of miRNAs with clinical behavior. This is the first report of clinically relevant miRNAs in ependymomas.