Miracle-dz/UniFAR-FTUs huggingface dataset:
Screening for Language Disorders in Stroke: German Validation of the Language Screening Test (LAST)

Background: Screening of aphasia in acute stroke is crucial for directing patients to early language therapy. The Language Screening Test (LAST), originally developed in French, is a validated language screening test that allows detection of a language deficit within a few minutes. The aim of the present study was to develop and validate two parallel German versions of the LAST. Methods: The LAST includes subtests for naming, repetition, automatic speech, and comprehension. For the translation into German, task constructs and psycholinguistic criteria for item selection were identical to the French LAST. A cohort of 101 stroke patients were tested, all of whom were native German speakers. Validation of the LAST was based on (1) analysis of equivalence of the German versions, which was established by administering both versions successively in a subset of patients, (2) internal validity by means of internal consistency analysis, and (3) external validity by comparison with the short version of the Token Test in another subset of patients. Results: The two German versions were equivalent as demonstrated by a high intraclass correlation coefficient of 0.91. Furthermore, an acceptable internal structure of the LAST was found (Cronbach's α = 0.74). A highly significant correlation (r = 0.74, p < 0.0001) between the LAST and the short version of the Token Test indicated good external validity of the scale. Conclusion: The German version of the LAST, available in two parallel versions, is a new and valid language screening test in stroke.
The impact of Internet policy and topology on delayed routing convergence

This paper examines the role inter-domain topology and routing policy play in the process of delayed Internet routing convergence. In previous work, we showed that the Internet lacks effective inter-domain path fail-over. Unlike circuit-switched networks which exhibit fail-over on the order of milliseconds, we found Internet backbone routers may take tens of minutes to reach a consistent view of the network topology after a fault. In this paper, we expand an our earlier work by exploring the impact of specific Internet provider policies and topologies on the speed of routing convergence. Based on data from the experimental injection and measurement of several hundred thousand inter-domain routing faults, we show that the time for end-to-end Internet convergence depends on the length of the longest possible backup autonomous system path between a source and destination node. We also demonstrate significant variation in the convergence behavior of Internet service providers, with the larger providers exhibiting the fastest convergence latencies. Finally, we discuss possible modifications to BGP and provider routing policies which if deployed, would improve inter-domain routing convergence.
Prediction of chronic obstructive pulmonary disease (COPD) in asthma patients using electronic medical records.

OBJECTIVE Identify clinical factors that modulate the risk of progression to COPD among asthma patients using data extracted from electronic medical records. DESIGN Demographic information and comorbidities from adult asthma patients who were observed for at least 5 years with initial observation dates between 1988 and 1998, were extracted from electronic medical records of the Partners Healthcare System using tools of the National Center for Biomedical Computing "Informatics for Integrating Biology to the Bedside" (i2b2). MEASUREMENTS A predictive model of COPD was constructed from a set of 9,349 patients (843 cases, 8,506 controls) using Bayesian networks. The model's predictive accuracy was tested using it to predict COPD in a future independent set of asthma patients (992 patients; 46 cases, 946 controls), who had initial observation dates between 1999 and 2002. RESULTS A Bayesian network model composed of age, sex, race, smoking history, and 8 comorbidity variables is able to predict COPD in the independent set of patients with an accuracy of 83.3%, computed as the area under the Receiver Operating Characteristic curve (AUROC). CONCLUSIONS Our results demonstrate that data extracted from electronic medical records can be used to create predictive models. With improvements in data extraction and inclusion of more variables, such models may prove to be clinically useful.
Can Attention Control Conditions Have Detrimental Effects on Behavioral Medicine Randomized Trials?

Objective Attention control (AC) conditions are used to balance nonspecific attention in randomized trials of behavioral interventions. Very little guidance about which behavioral interventions and outcomes merit AC is available in the literature. The primary aim of the present study is to demonstrate a scenario in which use of AC in a behavioral randomized trial was unnecessary and possibly detrimental. Methods Exploratory analyses were performed in a randomized controlled trial that tested whether a patient-centered counseling intervention reduced low-density lipoprotein cholesterol levels in 355 participants with peripheral arterial disease, compared with AC and usual care (UC) conditions. The patient-centered counseling intervention was designed to activate participants to ask their physician for lipid-lowering medication and/or increase dose intensity, increase medication adherence, and reduce fat intake. The AC condition involved attention-matched telephone-delivered health education, and the UC condition consisted of an educational pamphlet. Results At 12-month follow-up, the mean low-density lipoprotein cholesterol changes were −11.1 and −6.8 mg/dL in the UC and AC conditions, respectively (p = .17). The proportion of participants who increased the use or dose intensity of medication was significantly lower in AC than in UC: 17.5% versus 30.5% (p = .03). No significant difference in other outcomes was observed between AC and UC. Conclusions AC has significantly worse medication outcomes, and there is no indication of a therapeutic effect on other end points. Implications for the use of AC in behavioral randomized trials are discussed. Trial Registration clinicaltrials.gov Identifier: NCT00217919.
MultiLanes

OS-level virtualization is often used for server consolidation in data centers because of its high efficiency. However, the sharing of storage stack services among the colocated containers incurs contention on shared kernel data structures and locks within I/O stack, leading to severe performance degradation on manycore platforms incorporating fast storage technologies (e.g., SSDs based on nonvolatile memories). This article presents MultiLanes, a virtualized storage system for OS-level virtualization on manycores. MultiLanes builds an isolated I/O stack on top of a virtualized storage device for each container to eliminate contention on kernel data structures and locks between them, thus scaling them to manycores. Meanwhile, we propose a set of techniques to tune the overhead induced by storage-device virtualization to be negligible, and to scale the virtualized devices to manycores on the host, which itself scales poorly. To reduce the contention within each single container, we further propose SFS, which runs multiple file-system instances through the proposed virtualized storage devices, distributes all files under each directory among the underlying file-system instances, then stacks a unified namespace on top of them. The evaluation of our prototype system built for Linux container (LXC) on a 32-core machine with both a RAM disk and a modern flash-based SSD demonstrates that MultiLanes scales much better than Linux in micro- and macro-benchmarks, bringing significant performance improvements, and that MultiLanes with SFS can further reduce the contention within each single container.
HideM: Protecting the Contents of Userspace Memory in the Face of Disclosure Vulnerabilities

Memory disclosure vulnerabilities have become a common component for enabling reliable exploitation of systems by leaking the contents of executable data. Previous research towards protecting executable data from disclosure has failed to gain popularity due to large performance penalties and required architectural changes. Other research has focused on protecting application data but fails to consider a vulnerable application that leaks its own executable data. In this paper we present HideM, a practical system for protecting against memory disclosures in contemporary commodity systems. HideM addresses limitations in existing advanced security protections (e.g., fine-grained ASLR, CFI) wherein an adversary discloses executable data from memory, reasons about protection weaknesses, and builds corresponding exploits. HideM uses the split-TLB architecture, commonly found in CPUs, to enable fine-grained execute and read permission on memory. HideM enforces fine-grained permission based on policy generated from binary structure thus enabling protection of Commercial-Off-The-Shelf (COTS) binaries. In our evaluation of HideM, we find application overhead ranges from a 6.5% increase to a 2% reduction in runtime and observe runtime memory overhead ranging from 0.04% to 25%. HideM requires adversaries to guess ROP gadget locations making exploitation unreliable. We find adversaries have less than a 16% chance of correctly guessing a single gadget across all 28 evaluated applications. Thus, HideM is a practical system for protecting vulnerable applications which leak executable data.
Genomic Subtractive Hybridization and Selective Capture of Transcribed Sequences Identify a Novel Salmonella typhimurium Fimbrial Operon and Putative Transcriptional Regulator That Are Absent from the Salmonella typhi Genome

ABSTRACT Salmonella typhi, the etiologic agent of typhoid fever, is adapted to the human host and unable to infect nonprimate species. The genetic basis for host specificity in S. typhi is unknown. The avirulence of S. typhi in animal hosts may result from a lack of genes present in the broad-host-range pathogenSalmonella typhimurium. Genomic subtractive hybridization was successfully employed to isolate S. typhimurium genomic sequences which are absent from the S. typhi genome. These genomic subtracted sequences mapped to 17 regions distributed throughout the S. typhimurium chromosome. A positive cDNA selection method was then used to identify subtracted sequences which were transcribed by S. typhimurium following macrophage phagocytosis. A novel putative transcriptional regulator of the LysR family was identified as transcribed by intramacrophage S. typhimurium. This putative transcriptional regulator was absent from the genomes of the human-adapted serovars S. typhi andSalmonella paratyphi A. Mutations within this gene did not alter the level of S. typhimurium survival within macrophages or virulence within mice. A subtracted genomic fragment derived from the ferrichrome operon also hybridized to the intramacrophage cDNA. Nucleotide sequence analysis of S. typhimurium and S. typhi chromosomal sequences flanking the ferrichrome operon identified a novel S. typhimurium fimbrial operon with a high level of similarity to sequences encoding Proteus mirabilis mannose-resistant fimbriae. The novel fimbrial operon was absent from the S. typhi genome. The absence of specific genes may have allowedS. typhi to evolve as a highly invasive, systemic human pathogen.
Sex Differences and Emotion Regulation: An Event-Related Potential Study

Difficulties in emotion regulation have been implicated as a potential mechanism underlying anxiety and mood disorders. It is possible that sex differences in emotion regulation may contribute towards the heightened female prevalence for these disorders. Previous fMRI studies of sex differences in emotion regulation have shown mixed results, possibly due to difficulties in discriminating the component processes of early emotional reactivity and emotion regulation. The present study used event-related potentials (ERPs) to examine sex differences in N1 and N2 components (reflecting early emotional reactivity) and P3 and LPP components (reflecting emotion regulation). N1, N2, P3, and LPP were recorded from 20 men and 23 women who were instructed to “increase,” “decrease,” and “maintain” their emotional response during passive viewing of negative images. Results indicated that women had significantly greater N1 and N2 amplitudes (reflecting early emotional reactivity) to negative stimuli than men, supporting a female negativity bias. LPP amplitudes increased to the “increase” instruction, and women displayed greater LPP amplitudes than men to the “increase” instruction. There were no differences to the “decrease” instruction in women or men. These findings confirm predictions of the female negativity bias hypothesis and suggest that women have greater up-regulation of emotional responses to negative stimuli. This finding is highly significant in light of the female vulnerability for developing anxiety disorders.
Burkholderia pseudomallei Capsular Polysaccharide Conjugates Provide Protection against Acute Melioidosis

ABSTRACT Burkholderia pseudomallei, the etiologic agent of melioidosis, is a CDC tier 1 select agent that causes severe disease in both humans and animals. Diagnosis and treatment of melioidosis can be challenging, and in the absence of optimal chemotherapeutic intervention, acute disease is frequently fatal. Melioidosis is an emerging infectious disease for which there are currently no licensed vaccines. Due to the potential malicious use of B. pseudomallei as well as its impact on public health in regions where the disease is endemic, there is significant interest in developing vaccines for immunization against this disease. In the present study, type A O-polysaccharide (OPS) and manno-heptose capsular polysaccharide (CPS) antigens were isolated from nonpathogenic, select-agent-excluded strains of B. pseudomallei and covalently linked to carrier proteins. By using these conjugates (OPS2B1 and CPS2B1, respectively), it was shown that although high-titer IgG responses against the OPS or CPS component of the glycoconjugates could be raised in BALB/c mice, only those animals immunized with CPS2B1 were protected against intraperitoneal challenge with B. pseudomallei. Extending upon these studies, it was also demonstrated that when the mice were immunized with a combination of CPS2B1 and recombinant B. pseudomallei LolC, rather than with CPS2B1 or LolC individually, they exhibited higher survival rates when challenged with a lethal dose of B. pseudomallei. Collectively, these results suggest that CPS-based glycoconjugates are promising candidates for the development of subunit vaccines for immunization against melioidosis.
Islet Allograft Rejection Is Independent of Toll-Like Receptor Signaling in Mice

Background. Islet transplantation is a promising therapy for type 1 diabetes; however, most islet grafts fail within 5 years. Innate immunity has been suggested to play a role in islet allograft rejection, potentially mediated by toll-like receptors (TLRs), a class of innate immune receptors. Lack of TLR4, in particular, has been reported to improve allograft survival. Therefore, we hypothesized that TLRs may be involved in islet allograft rejection, and that deletion of TLR4 may improve islet graft survival. Methods. Islets were isolated from C57BL/10ScNJ (Tlr4−/−) and C57BL/10 (wild-type [WT]) animals and transplanted into Balb/cJ recipients with streptozotocin-induced diabetes. Blood glucose levels were used to determine graft viability and immunostaining to assess graft morphology and immune cell infiltration. The roles of the TLR4 adaptor molecules MyD88 and TLR adaptor molecule 1 (Ticam-1) were assessed using islets isolated from mice lacking MyD88 (MyD88−/−), Ticam-1 (Ticam-1−/−), or the combined double knockout (MyD88−/−/Ticam-1−/−). Results. Contrary to our hypothesis, Tlr4−/− and WT islet allografts had similar failure rates; grafts failed at 23.2±1.2 and 24.5±1.5 days posttransplant, respectively (P=NS). Syngeneic grafts of Tlr4−/− and WT islets maintained normoglycemia for up to 10 weeks posttransplant, indicating that failure of Tlr4−/− islet allografts could not be attributed to an intrinsic defect in Tlr4−/− islets. Similarly, islet allotransplants from MyD88−/−, Ticam-1−/−, and MyD88−/−/Ticam-1−/− donors did not have improved allograft survival compared with WT controls. Conclusions. These findings indicate that islet allograft rejection in mice is independent of TLR4 and the TLR adaptor molecules MyD88 and Ticam-1, speaking against an essential role for TLR signaling in islet allograft rejection.
Is Cancer Risk Associated With Anger Control and Negative Affect? Findings From a Prospective Cohort Study

Objective: To examine the associations between anger control and negative affect and the risk of five common cancers and total cancers. Possible associations between emotional states and the risk of cancer have long been postulated. Methods: Prospective cohort study with average follow-up of 9 years. A total of 19,730 adults (99% aged between 40 and 69 years) answered questions on negative affect and anger control at baseline. A total of 1952 cancers were diagnosed, including 352 breast cancers, 318 prostate cancers, 88 lung cancers, 280 colorectal cancers, and 261 melanomas. Results: After adjustment for potential confounders, there was no significant association between anger control or negative affect and risk of breast cancer, melanoma, or total cancers. Weak associations were identified between anger control and prostate cancer, hazards ratio (HR) 1.17 (1.04–1.30) for a 1-unit increase in the standardized scale, negative affect, and lung cancer, HR 1.24 (1.01–1.52) and colorectal cancer, HR 1.14 (1.01–1.28). There was no evidence of an interaction effect between anger control and negative affect. Conclusions: Results suggest that anger control and negative affect are not associated with breast cancer, melanoma, or total cancer risk, although they may have a small role in risk of prostate, colorectal, and lung cancer. Although more research is needed to confirm these latter associations, the results suggest that if affective states are associated with cancer development, the association may differ for different cancers and argue against the use of total cancer as an outcome measure for studies in this area. BMI = body mass index; CECS = Courtauld Emotional Control Scale; CI = confidence interval; HR = hazards ratio; HRT = hormone replacement therapy; MCCS = Melbourne Collaborative Cohort Study; MMPI = Minnesota Multiphasic Personality Inventory; PANAS = Positive And Negative Affect Scale.
How Important Are Work-Family Support Policies? A Meta-Analytic Investigation of Their Effects on Employee Outcomes

This meta-analysis examines relationships between work-family support policies, which are policies that provide support for dependent care responsibilities, and employee outcomes by developing a conceptual model detailing the psychological mechanisms through which policy availability and use relate to work attitudes. Bivariate results indicated that availability and use of work-family support policies had modest positive relationships with job satisfaction, affective commitment, and intentions to stay. Further, tests of differences in effect sizes showed that policy availability was more strongly related to job satisfaction, affective commitment, and intentions to stay than was policy use. Subsequent meta-analytic structural equation modeling results indicated that policy availability and use had modest effects on work attitudes, which were partially mediated by family-supportive organization perceptions and work-to-family conflict, respectively. Additionally, number of policies and sample characteristics (percent women, percent married-cohabiting, percent with dependents) moderated the effects of policy availability and use on outcomes. Implications of these findings and directions for future research on work-family support policies are discussed.
An rRNA variable region has an evolutionarily conserved essential role despite sequence divergence

Regions extremely variable in size and sequence occur at conserved locations in eukaryotic rRNAs. The functional importance of one such region was determined by gene reconstruction and replacement in Tetrahymena thermophila. Deletion of the D8 region of the large-subunit rRNA inactivates T. thermophila rRNA genes (rDNA): transformants containing only this type of rDNA are unable to grow. Replacement with an unrelated sequence of similar size or a variable region from a different position in the rRNA also inactivated the rDNA. Mutant rRNAs resulting from such constructs were present only in precursor forms, suggesting that these rRNAs are deficient in either processing or stabilization of the mature form. Replacement with D8 regions from three other organisms restored function, even though the sequences are very different. Thus, these D8 regions share an essential functional feature that is not reflected in their primary sequences. Similar tertiary structures may be the quality these sequences share that allows them to function interchangeably.
Group Equivariant Convolutional Networks

We introduce Group equivariant Convolutional Neural Networks (G-CNNs), a natural generalization of convolutional neural networks that reduces sample complexity by exploiting symmetries. G-CNNs use G-convolutions, a new type of layer that enjoys a substantially higher degree of weight sharing than regular convolution layers. G-convolutions increase the expressive capacity of the network without increasing the number of parameters. Group convolution layers are easy to use and can be implemented with negligible computational overhead for discrete groups generated by translations, reflections and rotations. G-CNNs achieve state of the art results on CI- FAR10 and rotated MNIST.
Contrast-Enhanced Ultrasound for the Evaluation of Neovascularization in Atherosclerotic Carotid Artery Plaques

Background and Purpose— Neovascularization associated with plaque vulnerability, particularly in the plaque shoulder, is susceptible to rupture, causing ischemic events. We aimed to use contrast-enhanced ultrasound to evaluate neovessels in carotid plaques quantitatively, focusing on plaque shoulders. Methods— Using contrast-enhanced ultrasound with perflubutane, we analyzed 50 consecutive patients who underwent carotid endarterectomy. We measured enhanced intensity and assessed the correlation between contrast effect and histopathology, comparing symptomatic and asymptomatic plaques. Results— Enhanced intensity of the plaque shoulder was associated with neovessel density (P<0.01; &rgr;=0.43). Enhanced intensity of the plaque shoulder was higher in plaques with rupture than in those without (P<0.05), and in symptomatic plaques (n=31) than in asymptomatic ones (n=19; P<0.01). Conclusions— Quantitative evaluation of the contrast effect using contrast-enhanced ultrasound enabled the assessment of neovascularization of plaque shoulders in vivo real time, which may help stratify plaque vulnerability.