Miracle-dz/UniFAR-FTUs huggingface dataset:
Athymic mice reveal a requirement for T-cell–microglia interactions in establishing a microenvironment supportive of Nf1 low-grade glioma growth

Murine Neurofibromatosis-1 (Nf1) optic low-grade glioma (LGG) stem cells (o-GSCs) form glioma-like lesions in wild-type, but not athymic, mice following transplantation. Here, Pan et al. show that the inability of athymic mice to support o-GSC engraftment results from impaired brain microglia/macrophage function, including reduced expression of Ccr2 and Ccl5, both of which are required for o-GSC engraftment and Nf1 optic glioma growth.
Bias in reporting of end points of efficacy and toxicity in randomized, clinical trials for women with breast cancer.

BACKGROUND Phase III randomized, clinical trials (RCTs) assess clinically important differences in end points that reflect benefit to patients. Here, we evaluate the quality of reporting of the primary end point (PE) and of toxicity in RCTs for breast cancer. METHODS PUBMED was searched from 1995 to 2011 to identify RCTs for breast cancer. Bias in the reporting of the PE and of toxicity was assessed using pre-designed algorithms. Associations of bias with the Journal Impact Factor (JIF), changes in the PE compared with information in ClinicalTrials.gov and funding source were evaluated. RESULTS Of 164 included trials, 33% showed bias in reporting of the PE and 67% in the reporting of toxicity. The PE was more likely to be reported in the concluding statement of the abstract when significant differences favoring the experimental arm were shown; 59% of 92 trials with a negative PE used secondary end points to suggest benefit of experimental therapy. Only 32% of articles indicated the frequency of grade 3 and 4 toxicities in the abstract. A positive PE was associated with under-reporting of toxicity. CONCLUSION Bias in reporting of outcome is common for studies with negative PEs. Reporting of toxicity is poor, especially for studies with positive PEs.
Accommodating Grief on Twitter: An Analysis of Expressions of Grief Among Gang Involved Youth on Twitter Using Qualitative Analysis and Natural Language Processing

There is a dearth of research investigating youths’ experience of grief and mourning after the death of close friends or family. Even less research has explored the question of how youth use social media sites to engage in the grieving process. This study employs qualitative analysis and natural language processing to examine tweets that follow 2 deaths. First, we conducted a close textual read on a sample of tweets by Gakirah Barnes, a gang-involved teenaged girl in Chicago, and members of her Twitter network, over a 19-day period in 2014 during which 2 significant deaths occurred: that of Raason “Lil B” Shaw and Gakirah’s own death. We leverage the grief literature to understand the way Gakirah and her peers express thoughts, feelings, and behaviors at the time of these deaths. We also present and explain the rich and complex style of online communication among gang-involved youth, one that has been overlooked in prior research. Next, we overview the natural language processing output for expressions of loss and grief in our data set based on qualitative findings and present an error analysis on its output for grief. We conclude with a call for interdisciplinary research that analyzes online and offline behaviors to help understand physical and emotional violence and other problematic behaviors prevalent among marginalized communities.
A Welfare Analysis of Secondary Use of Personal Data

Personal information on individuals is increasingly shared between companies that do not belong to the same industry. Such exchange may occur for purposes of risk assessment, identity veri cation or cross-marketing. Secondary purposes of data use are regulated under the European Data Protection Directive, but implementation in Europe di¤ers from one country to another. At the EU level, there is currently a controversial discussion whether such sharing is bene tial from a consumers perspective. In this paper, I discuss the impact of data protection regimes on rmscapabilities of information sharing and price discrimination. Data protection regimes induce rent-shifting among rms and consumers and it can be shown that given data protection rules not all consumers bene t equally from compensation for information disclosure. JEL-Classi cation: D43; L14; O30.
Effect of Different Adhesive Systems Used for Immediate Dentin Sealing on Bond Strength of a Self-Adhesive Resin Cement to Dentin.

OBJECTIVE The purpose of this study was to investigate the immediate and three-month water storage behavior of adhesives when used for immediate dentin sealing (IDS). METHODS AND MATERIALS Four adhesive systems were used to perform IDS: a one-step self-etch (Xeno V), a two-step self-etch (Clearfil SE Bond), a two-step etch-and-rinse (XP Bond), and a three-step etch-and-rinse (Optibond FL). For the control group, IDS was not performed. The self-adhesive resin cement RelyX Unicem was used for the luting procedures. After seven days of water storage, specimens (n=6) were sectioned into beams (n=5) with an approximately 1-mm2 cross-sectional area. Half of the specimens were tested in tension after seven days of water storage at 37°C, while the other half was stored for three months prior to testing in tension using a universal testing machine (1 mm/min). The failure pattern was determined using a stereomicroscope and scanning electron microscopy. Microtensile bond strength (μTBS) data were statistically analyzed by two-way analysis of variance and Tukey post hoc test (α=0.05). RESULTS After seven days, the control group presented the lowest μTBS but did not differ from XP Bond and Clearfil SE Bond. After three months, there was no μTBS difference between the IDS groups and the control. CONCLUSIONS After seven days of water storage, the groups with IDS presented higher μTBS values than the control group, although XP Bond and Clearfil SE Bond did not present significant differences. However, after three months of storage in water, IDS groups did not differ significantly from control group, which did not receive IDS.
Spectral slicing filters in titanium diffused lithium niobate (ti:linbo3)

Spectral Slicing Filters in Titanium Diffused Lithium Niobate (Ti:LiNbO3). (December 2008) Renato Cunha Rabelo, B.S., Instituto Tecnológico de Aeronáutica; M.S., Instituto Tecnológico de Aeronáutica Chair of Advisory Committee: Dr. Ohannes Eknoyan A tunable guided-wave optical filter that performs spectral slicing at the 1530nm wavelength regime in Ti:LiNbO3 was proposed and fabricated. It is aimed at minimizing crosstalk between channels in dense wavelength division multiplexing (DWDM) optical network applications. The design utilizes a sparse grating allowing the selection of equally spaced channels in the frequency domain. Between selected channels, equally spaced nulls are also produced. The sparse grating is formed by using N coupling regions with different lengths along the direction of propagation of light in the waveguide, generating N-1 equally spaced nulls between adjacent selected channels. The distance between the centers of adjacent coupling regions is kept constant. The filtering is based on codirectional polarization coupling between transverse electric (TE) and transverse magnetic (TM) orthogonal modes in a waveguide through an overlay of strain-induced index grating, via the strain-optic effect. Two types of devices were fabricated. In the first type, the sparse gratings were produced on straight channel waveguides. Selected channels emerge from the device in a
The Effects of Altitude Training on Erythropoietic Response and Hematological Variables in Adult Athletes: A Narrative Review

Background: One of the goals of altitude training is to increase blood oxygen-carrying capacity in order to improve sea-level endurance performance in athletes. The elevated erythropoietin (EPO) production in hypoxia is a key factor in the achievement of enhanced hematological variables. The level of the EPO increase and acceleration of erythropoiesis depend on the duration of exposure and degree of hypoxia. Furthermore, many other factors may affect the hematological response to altitude training. Aim: The purpose of this narrative review was to: (1) analyze the kinetics of EPO and hematological variables during and after altitude training; (2) summarize the current state of knowledge about the possible causes of individual or cohort differences in EPO and hematological response to altitude training; (3) formulate practical guidelines for athletes to improve the efficiency of altitude training. Methods: A narrative review was performed following an electronic search of the databases PubMed/MEDLINE and SPORTDiscus via EBSCO for all English-language articles published between 1997 and 2017. Results: Complete unification of results from studies on EPO kinetics was difficult due to different time and frequency of blood sampling by different researchers during and after altitude training, but the data presented in the reviewed literature allowed us to detect certain trends. The results of the reviewed studies were divergent and indicated either increase or no change of hematological variables following altitude training. Factors that may affect the hematological response to altitude training include hypoxic dose, training content, training background of athletes, and/or individual variability of EPO production. Conclusions: Despite the potential benefits arising from altitude training, its effectiveness in improving hematological variables is still debatable. Further research and better understanding of factors influencing the response to altitude, as well as factors affecting the suitable measurement and interpretation of study results, are needed.
Gender Bias, Social Impact Framing, and Evaluation of Entrepreneurial Ventures

Recent studies find that female-led ventures are penalized relative to male-led ventures as a result of role incongruity or a perceived “lack of fit” between female stereotypes and expected personal qualities of business entrepreneurs. We examine whether social impact framing that emphasizes a venture’s social–environmental welfare benefits, which research has shown to elicit stereotypically feminine attributions of warmth, diminishes these penalties. We initially investigate this proposition in a field study of evaluations of early-stage ventures and find evidence of lessened gender penalties for female-led ventures that are presented using a social impact frame. In a second study, we experimentally validate this effect and show that it is mediated by the effect of social impact framing on perceptions of the entrepreneur’s warmth. The effect of social impact frames on venture evaluations did not apply to men, was not a result of perceptions of increased competence, and was not conditional on the gender o.
Size Effect Tests of High Strength Concrete

Results of failure of cylinders under the uniaxial compression are reported. Cylinders of three different diameters (37.5, 75, and 150 mm) were tested. For all the cylinders, the height to diameter ratio was \ih/\id=2. The cylinders were made of microconcrete with maximum aggregate size 4.76 mm and the compressive strength (\if\i\dc’) of concrete was found between 34 and 48 MPa depending on the size of specimens. The concrete mix proportions of water:cement:aggregate:silica fume:superplasticizer were 0.3:1:4:0.1:0.08. The results reveal the existence of a significant size effect that can be approximately described by the size effect law previously proposed by Bazant. The experiments indicate that larger specimens tend to fail in a more brittle manner, while smaller specimens tend to fail in a less brittle or more plastic failure.
Prognostic value of increased integrin-beta 1 expression in solid cancers: a meta-analysis

Integrin-beta 1 (ITGB1) is aberrantly overexpressed or downregulated in solid cancers; however, its prognostic value remains controversial. Therefore, we conducted a meta-analysis to explore whether ITGB1 expression is correlated with overall survival (OS) and the clinicopathological characteristics of patients with solid cancers. We systematically searched the PubMed, Embase, and Web of Science databases for eligible studies published up to June 1, 2017. In total, 22 studies involving 3,666 patients were included. A sensitivity analysis was performed to assess the validity and reliability of the pooled OS. Among the 22 studies, 7 focused on lung cancer, 3 focused on colorectal cancer, 6 focused on breast cancer, 3 involved melanoma, and 3 involved pancreatic cancer. The pooled results showed that high ITGB1 expression was significantly associated with worse OS in lung cancer (pooled hazard ratio [HR]=1.78, 95% CI: 1.19–2.65, p<0.05) and breast cancer (pooled HR=1.88, 95% CI: 1.46–2.42, p<0.01). In addition, a significant association was observed between high ITGB1 expression and disease-free survival in breast cancer (pooled HR=1.63, 95% CI: 1.17–2.25, p<0.001) and pancreatic cancer (pooled HR=2.49, 95% CI: 1.35–4.61, p<0.001). However, high ITGB1 expression was not related to OS in colorectal cancer, pancreatic cancer, or melanoma. The pooled HRs used to evaluate the prognostic value of increased ITGB1 expression in lung cancer, breast cancer, and pancreatic cancer were not significantly altered, which indicates that the pooled results were robust. The results of this study indicate that the prognostic value of decreased ITGB1 expression varies among solid cancers.
Do wild-caught urban house sparrows show desensitized stress responses to a novel stressor?

ABSTRACT While urbanization exposes individuals to novel challenges, urban areas may also constitute stable environments in which seasonal fluctuations are buffered. Baseline and stress-induced plasma corticosterone (cort) levels are often found to be similar in urban and rural populations. Here we aimed to disentangle two possible mechanisms underlying such pattern: (i) urban environments are no more stressful or urban birds have a better ability to habituate to stressors; or (ii) urban birds developed desensitized stress responses. We exposed wild-caught urban and rural house sparrows (Passer domesticus) to combined captivity and diet treatments (urban versus rural diet) and measured corticosterone levels both in natural tail feathers and in regrown homologous ones (cortf). Urban and rural house sparrows showed similar cortf levels in the wild and in response to novel stressors caused by the experiment, supporting the growing notion that urban environments are no more stressful during the non-breeding season than are rural ones. Still, juveniles and males originating from urban populations showed the highest cortf levels in regrown feathers. We did not find evidence that cortf was consistent within individuals across moults. Our study stresses the need for incorporating both intrinsic and environmental factors for the interpretation of variation in cortf between populations. Summary: Corticosterone in natural and regrown feathers was similar between urban and rural birds. Sex and age related to corticosterone in regrown feathers. Feather corticosterone was not consistent across different moults.
Qualitative Multi-Armed Bandits: A Quantile-Based Approach

We formalize and study the multi-armed bandit (MAB) problem in a generalized stochastic setting, in which rewards are not assumed to be numerical. Instead, rewards are measured on a qualitative scale that allows for comparison but invalidates arithmetic operations such as averaging. Correspondingly, instead of characterizing an arm in terms of the mean of the underlying distribution, we opt for using a quantile of that distribution as a representative value. We address the problem of quantile-based online learning both for the case of a finite (pure exploration) and infinite time horizon (cumulative regret minimization). For both cases, we propose suitable algorithms and analyze their properties. These properties are also illustrated by means of first experimental studies.
In vivo bioassay to test the pathogenicity of missense human AIP variants

Background Heterozygous germline loss-of-function mutations in the aryl hydrocarbon receptor-interacting protein gene (AIP) predispose to childhood-onset pituitary tumours. The pathogenicity of missense variants may pose difficulties for genetic counselling and family follow-up. Objective To develop an in vivo system to test the pathogenicity of human AIP mutations using the fruit fly Drosophila melanogaster. Methods We generated a null mutant of the Drosophila AIP orthologue, CG1847, a gene located on the Xchromosome, which displayed lethality at larval stage in hemizygous knockout male mutants (CG1847exon1_3 ). We tested human missense variants of ‘unknown significance’, with ‘pathogenic’ variants as positive control. Results We found that human AIP can functionally substitute for CG1847, as heterologous overexpression of human AIP rescued male CG1847exon1_3 lethality, while a truncated version of AIP did not restore viability. Flies harbouring patient-specific missense AIP variants (p.C238Y, p.I13N, p.W73R and p.G272D) failed to rescue CG1847exon1_3 mutants, while seven variants (p.R16H, p.Q164R, p.E293V, p.A299V, p.R304Q, p.R314W and p.R325Q) showed rescue, supporting a non-pathogenic role for these latter variants corresponding to prevalence and clinical data. Conclusion Our in vivo model represents a valuable tool to characterise putative disease-causing human AIP variants and assist the genetic counselling and management of families carrying AIP variants.
Photobiomodulation Leads to Reduced Oxidative Stress in Rats Submitted to High-Intensity Resistive Exercise

The aim of this study was to determine whether oxidative stress markers are influenced by low-intensity laser therapy (LLLT) in rats subjected to a high-intensity resistive exercise session (RE). Female Wistar rats divided into three experimental groups (Ctr: control, 4J: LLLT, and RE) and subdivided based on the sampling times (instantly or 24 h postexercise) underwent irradiation with LLLT using three-point transcutaneous method on the hind legs, which was applied to the gastrocnemius muscle at the distal, medial, and proximal points. Laser (4J) or placebo (device off) were carried out 60 sec prior to RE that consisted of four climbs bearing the maximum load with a 2 min time interval between each climb. Lipoperoxidation levels and antioxidant capacity were obtained in muscle. Lipoperoxidation levels were increased (4-HNE and CL markers) instantly post-RE. LLLT prior to RE avoided the increase of the lipid peroxidation levels. Similar results were also notified for oxidation protein assays. The GPx and FRAP activities did not reduce instantly or 24 h after RE. SOD increased 24 h after RE, while CAT activity did not change with RE or LLLT. In conclusion, LLLT prior to RE reduced the oxidative stress markers, as well as, avoided reduction, and still increased the antioxidant capacity.
DataInk: Direct and Creative Data-Oriented Drawing

Creating whimsical, personal data visualizations remains a challenge due to a lack of tools that enable for creative visual expression while providing support to bind graphical content to data. Many data analysis and visualization creation tools target the quick generation of visual representations, but lack the functionality necessary for graphics design. Toolkits and charting libraries offer more expressive power, but require expert programming skills to achieve custom designs. In contrast, sketching affords fluid experimentation with visual shapes and layouts in a free-form manner, but requires one to manually draw every single data point. We aim to bridge the gap between these extremes. We propose DataInk, a system supports the creation of expressive data visualizations with rigorous direct manipulation via direct pen and touch input. Leveraging our commonly held skills, coupled with a novel graphical user interface, DataInk enables direct, fluid, and flexible authoring of creative data visualizations.
Seeded Growth Route to Noble Calcium Carbonate Nanocrystal

A solution-phase route has been considered as the most promising route to synthesize noble nanostructures. A majority of their synthesis approaches of calcium carbonate (CaCO3) are based on either using fungi or the CO2 bubbling methods. Here, we approached the preparation of nano-precipitated calcium carbonate single crystal from salmacis sphaeroides in the presence of zwitterionic or cationic biosurfactants without external source of CO2. The calcium carbonate crystals were rhombohedron structure and regularly shaped with side dimension ranging from 33–41 nm. The high degree of morphological control of CaCO3 nanocrystals suggested that surfactants are capable of strongly interacting with the CaCO3 surface and control the nucleation and growth direction of calcium carbonate nanocrystals. Finally, the mechanism of formation of nanocrystals in light of proposed routes was also discussed.
Constitutive activation of kappa opioid receptors at ventral tegmental area inhibitory synapses following acute stress

Stressful experiences potently activate kappa opioid receptors (κORs). κORs in the ventral tegmental area regulate multiple aspects of dopaminergic and non-dopaminergic cell function. Here we show that at GABAergic synapses on rat VTA dopamine neurons, a single exposure to a brief cold-water swim stress induces prolonged activation of κORs. This is mediated by activation of the receptor during the stressor followed by a persistent, ligand-independent constitutive activation of the κOR itself. This lasting change in function is not seen at κORs at neighboring excitatory synapses, suggesting distinct time courses and mechanisms of regulation of different subsets of κORs. We also provide evidence that constitutive activity of κORs governs the prolonged reinstatement to cocaine-seeking observed after cold water swim stress. Together, our studies indicate that stress-induced constitutive activation is a novel mechanism of κOR regulation that plays a critical role in reinstatement of drug seeking. DOI: http://dx.doi. org/10.7554/eLife.23785. 001
Spec: a framework for the specification and reuse of UIs and their models

Implementing UIs is often a tedious task. To address this, UI Builders have been proposed to support the description of widgets, their location, and their logic. A missing aspect of UI Builders is however the ability to reuse and compose widget logic. In our experience, this leads to a significant amount of duplication in UI code. To address this issue, we built Spec: a UIBuilder for Pharo with a focus on reuse. With Spec, widget properties are defined declaratively and attached to specific classes known as composable classes. A composable class defines its own widget description as well as the model-widget bridge and widget interaction logic. This paper presents Spec, showing how it enables seamless reuse of widgets and how these can be customized. After presenting Spec and its implementation, we discuss how its use in Pharo 2.0 has cut in half the amount of lines of code of six of its tools, mostly through reuse. This shows that Spec meets its goals of allowing reuse and composition of widget logic.