Miracle-dz/UniFAR-FTUs huggingface dataset:
Antipsychotic Augmentation of Serotonin Reuptake Inhibitors in Treatment-Resistant Obsessive-Compulsive Disorder: An Update Meta-Analysis of Double-Blind, Randomized, Placebo-Controlled Trials

Background: Many patients with obsessive-compulsive disorder do not respond adequately to serotonin reuptake inhibitors. Augmentation with antipsychotic drugs can be beneficial in this regard. However, since new relevant randomized controlled trials evaluating new antipsychotics were conducted, a recalculation of the effect sizes appears necessary. Methods: We meta-analyzed all double-blind, randomized, placebo-controlled trials comparing augmentation of serotonin reuptake inhibitors with antipsychotics to placebo supplementation in treatment-resistant obsessive-compulsive disorder. The primary outcome was mean change in the Yale-Brown Obsessive–Compulsive Scale total score. Secondary outcomes were obsessions, compulsions, response rates, and attrition rates. The data collection process was conducted independently by 2 authors. Hedges’s g and risks ratios were calculated as effect sizes. In preplanned meta-regressions, subgroup analyses, and sensitivity analyses, we examined the robustness of the results and explored reasons for potential heterogeneity. Results: Altogether, 14 double-blind, randomized, placebo-controlled trials (n=491) investigating quetiapine (N=4, n=142), risperidone (N=4, n=132), aripiprazole (N=2, n=79), olanzapine (N=2, n=70), paliperidone (N=1, n=34), and haloperidol (N=1, n=34) were incorporated. Augmentation with antipsychotics was significantly more efficacious than placebo in Yale-Brown Obsessive–Compulsive Scale total reduction (N=14, n=478; Hedges’s g=-0.64, 95% CI: -0.87 to -0.41; P=<.01). Aripiprazole (Hedges’s g=-1.35), haloperidol (Hedges’s g=-0.82), and risperidone (Hedges’s g=-0.59) significantly outperformed placebo. Antipsychotics were superior to placebo in treating obsessions, compulsions, and achieving response. There was no between-group difference concerning all-cause discontinuation. The nonsignificant meta-regressions suggest no influence of the antipsychotic dose or baseline symptom severity on the meta-analytic results. Conclusions: According to our findings, antipsychotic augmentation of serotonin reuptake inhibitors can be regarded as an evidence-based measure in treatment-resistant obsessive-compulsive disorder.
Gel filtration.

Gel filtration: For gel filtration 1,5mg protein was fractionated on a calibrated Ultrogel AcA34 (Pall Life Sciences, Vienna, Austria) or Superose 6 (GE Healthcare, Munich, Germany) filled Tricorn 10/600 column (GE Healthcare) run on a BioLogic Dual system (BioRad) at 4°C in lysis buffer at 0.5ml/min. 1ml fractions were collected, precipitated with TCA and analysed by immunoblotting as described previously (Geley et al., 2001;Wolf et al., 2006).
Positive direct antiglobulin tests due to clavulanic acid

Clavulanic acid, a beta-lactamase inhibitor, was found to be associated with the development of a positive direct antiglobulin test. Of 23 antibiotic courses in patients treated with ticarcillin, clavulanic acid, and tobramycin, 10 (43.5%) developed positive direct antiglobulin tests versus 2 of 26 (7.7%) patients treated with piperacillin and tobramycin (P = 0.0044). In vitro immunohematological studies showed that clavulanic acid caused a nonimmunologic adsorption of plasma proteins onto the erythrocyte surface. Hemolysis was not associated with such nonimmunologic adsorption. However, the resulting positive antiglobulin test might delay cross matching of blood products for transfusions or interfere with the evaluation of true immune-mediated hemolytic anemia.
Regular, brief mindfulness meditation practice improves electrophysiological markers of attentional control

Mindfulness-based meditation practices involve various attentional skills, including the ability to sustain and focus ones attention. During a simple mindful breathing practice, sustained attention is required to maintain focus on the breath while cognitive control is required to detect mind wandering. We thus hypothesized that regular, brief mindfulness training would result in improvements in the self-regulation of attention and foster changes in neuronal activity related to attentional control. A longitudinal randomized control group EEG study was conducted. At baseline (T1), 40 meditation naïve participants were randomized into a wait list group and a meditation group, who received three hours mindfulness meditation training. Twenty-eight participants remained in the final analysis. At T1, after eight weeks (T2) and after 16 weeks (T3), all participants performed a computerized Stroop task (a measure of attentional control) while the 64-channel EEG was recorded. Between T1 and T3 the meditators were requested to meditate daily for 10 min. Event-related potential (ERP) analysis highlighted two between group effects that developed over the course of the 16-week mindfulness training. An early effect at left and right posterior sites 160–240 ms post-stimulus indicated that meditation practice improved the focusing of attentional resources. A second effect at central posterior sites 310–380 ms post-stimulus reflects that meditation practice reduced the recruitment of resources during object recognition processes, especially for incongruent stimuli. Scalp topographies and source analyses (Variable Resolution Electromagnetic Tomography, VARETA) indicate relevant changes in neural sources, pertaining to left medial and lateral occipitotemporal areas for the early effect and right lateral occipitotemporal and inferior temporal areas for the later effect. The results suggest that mindfulness meditation may alter the efficiency of allocating cognitive resources, leading to improved self-regulation of attention.
Qualitative Self-Localization using a Spatio-Temporal Ontology: A Preliminary Report

Self-localization the correlation of current and former impressions of the world is an essential ability for most mobile agents. In an inhabited dynamic system, high precision metric approaches demand accurate sensor devices and large computational power. In contrast, during the last few years qualitative methods have been explored to overcome mainly problems regarding complexity and stability. This paper describes a qualitative approach to self-localization. With space-time as the ontological primitive and using distinct spatiotemporal patterns for categories of objects, selflocalization within an integrated spatio-temporal framework is investigated. Given a record of local surveys, we show how space-time history descriptions might be abduced from local surveys and spatio-temporal patterns. The qualitative mereotopological world model so constructed forms a basis for self-localization. keywords: spatio-temporal reasoning, selflocalization, space-time.
Simple Method for Predicting a Cable Shielding Factor , Based on Transfer Impedance

F or a shielded cable, an approximate relationship valid from few kHz up to the first cable resonance can be derived from its Transfer Impedance (Zt ) allowing to predict the cable shielding factor. This Cable Shielding factor, as a figure of merit, is often preferred by engineers dealing with product specifications and early design. Being not necessarily EMC specialists, they can relate it directly to the overall shielding performance required for a system boxes or cabinets. This article comes up with very simple, practical formulas, that directly express the cable shielding factor Kr, given its Zt and frequency.
Developmental differentiation of anxiety and affective neuroses

ABSTRACT– One hundred and fifty anxiety neurotic and neurotic depressive twin probands were differentiated into three groups by means of discriminant analysis, 50 in each group. The groups were named pure anxiety neurosis, mixed anxiety‐depression and pure neurotic depression. Childhood environmental factors seemed important in the development of pure neurotic depression, while mixed anxiety‐depression seemed to be determined by environmental factors in adult life. Further investigation showed that loss of a parent before the age of 16, and moving before the age of 14 seemed important in the development of pure neurotic depression. Loss, or threat of loss, of love objects appeared to be the most common precipitating event for the neurotic depression and mixed anxiety‐depression groups, while pregnancy and childbirth seemed to be of great significance in the development of pure anxiety neuroses. Furthermore, unmarried status was most frequent in the mixed anxiety‐depressive group of probands.
Research Note: The Relationship between Ethical Conflict, Organizational Commitment and Turnover Intentions in the Salesforce

Value congruence is believed to be an important determinant of job-related outcomes. The extent to which ethical conflict, resulting from incongruence in ethical values between salespeople and their organizations, affects given job related outcomes is not well understood. This study empirically examines the influence of ethical conflict on salespeople's organizational commitment and turnover intentions. Results suggest that ethical conflict is negatively associated with organizational commitment and positively associated with turnover intentions. Implications and directions for future research are provided.
Which Step Do I Take First? Troubleshooting with Bayesian Models

Online discussion forums and community question-answering websites provide one of the primary avenues for online users to share information. In this paper, we propose text mining techniques which aid users navigate troubleshooting-oriented data such as questions asked on forums and their suggested solutions. We introduce Bayesian generative models of the troubleshooting data and apply them to two interrelated tasks: (a) predicting the complexity of the solutions (e.g., plugging a keyboard in the computer is easier compared to installing a special driver) and (b) presenting them in a ranked order from least to most complex. Experimental results show that our models are on par with human performance on these tasks, while outperforming baselines based on solution length or readability.
Biochemical Studies on the Cardioprotective Effect of Glutamine on Tissue Antioxidant Defense System in Isoprenaline-Induced Myocardial Infarction in Rats

Oxidative stress is one of the mechanisms with a central role involved in the pathogenesis of myocardial infarction. The protective effect of glutamine on myocardial antioxidant defense system was investigated during isoprenaline-induced myocardial infarction, an animal model of myocardial infarction of human beings. Levels of diagnostic marker enzymes in plasma, reduced glutathione (GSH) and lipid peroxides and the activities of glutathione peroxidase, glutathione-S-transferase, catalase and superoxide dismutase in heart tissue were determined. Injection of isoprenaline caused significant increases in the levels of diagnostic marker enzymes in plasma and lipid peroxidation in heart tissue. A parallel decline in the levels of ATP (Adenosine triphosphate) and GSH and the activities of glutathione-dependent antioxidant enzymes and antiperoxidative enzymes in heart tissue was also observed. Prior oral administration of glutamine significantly prevented isoprenaline-induced adverse effects and maintained myocardial antioxidant status at near normal status. The cardioprotective effect of glutamine is probably related to a strengthening of the myocardial membrane by its membrane stabilizing action, or to a counteraction of free radicals by its antioxidant property, or to its ability to maintain near to normal status the activities of free radical scavenging enzymes and the level of GSH, which protect myocardial membrane against oxidative damage by decreasing lipid peroxidation.
Cardiomyocyte Specific Ablation of p53 Is Not Sufficient to Block Doxorubicin Induced Cardiac Fibrosis and Associated Cytoskeletal Changes

Doxorubicin (Dox) is an anthracycline used to effectively treat several forms of cancer. Unfortunately, the use of Dox is limited due to its association with cardiovascular complications which are manifested as acute and chronic cardiotoxicity. The pathophysiological mechanism of Dox induced cardiotoxicity appears to involve increased expression of the tumor suppressor protein p53 in cardiomyocytes, followed by cellular apoptosis. It is not known whether downregulation of p53 expression in cardiomyocytes would result in decreased rates of myocardial fibrosis which occurs in response to cardiomyocyte loss. Further, it is not known whether Dox can induce perivascular necrosis and associated fibrosis in the heart. In this study we measured the effects of acute Dox treatment on myocardial and perivascular apoptosis and fibrosis in a conditional knockout (CKO) mouse model system which harbours inactive p53 alleles specifically in cardiomyocytes. CKO mice treated with a single dose of Dox (20 mg/kg), did not display lower levels of myocardial apoptosis or reactive oxygen and nitrogen species (ROS/RNS) compared to control mice with intact p53 alleles. Interestingly, CKO mice also displayed higher levels of interstitial and perivascular fibrosis compared to controls 3 or 7 days after Dox treatment. Additionally, the decrease in levels of the microtubule protein α-tubulin, which occurs in response to Dox treatment, was not prevented in CKO mice. Overall, these results indicate that selective loss of p53 in cardiomyocytes is not sufficient to prevent Dox induced myocardial ROS/RNS generation, apoptosis, interstitial fibrosis and perivascular fibrosis. Further, these results support a role for p53 independent apoptotic pathways leading to Dox induced myocardial damage and highlight the importance of vascular lesions in Dox induced cardiotoxicity.
Age-Related Changes in Human Anatomical and Functional Brain Networks

At rest, the brain’s sensorimotor and higher cognitive systems engage in organized patterns of correlated activity forming resting-state networks. An important empirical question is how functional connectivity and structural connectivity within and between resting-state networks change with age. In this study we use network modeling techniques to identify significant changes in network organization across the human lifespan. The results of this study demonstrate that whole-brain functional and structural connectivity both exhibit reorganization with age. On average, functional connections within resting-state networks weaken in magnitude while connections between resting-state networks tend to increase. These changes can be localized to a small subset of functional connections that exhibit systematic changes across the lifespan. Collectively, changes in functional connectivity are also manifest at a system-wide
Coping and Attitudes Toward Dying and Death in German Adults

The idea of an existential threat caused by the awareness of mortality has been rarely investigated within coping research. The study explores relationships between coping strategies and attitudes toward dying and death in a sample of German adults aged 20 to 93 years. Participants responded to a Stress Coping Inventory and a questionnaire for the multidimensional assessment of attitudes toward dying and death. Pearson correlations for men, women, and the young and old age-groups confirm the expectation that attitudes toward dying and death are mainly associated with disengagement and accommodative coping. Gender- and age-specific findings refer to drug intake and aggression. Results are discussed within both a coping and a thanatological frame of reference and issues for future research are outlined.
Exploitation of Herpesviral Transactivation Allows Quantitative Reporter Gene-Based Assessment of Virus Entry and Neutralization

Herpesviral entry is a highly elaborated process requiring many proteins to act in precise conjunction. Neutralizing antibodies interfere with this process to abrogate viral infection. Based on promoter transactivation of a reporter gene we established a novel method to quantify herpesvirus entry and neutralization by antibodies. Following infection with mouse and human cytomegalovirus and Herpes simplex virus 1 we observed promoter transactivation resulting in substantial luciferase expression (>1000-fold). No induction was elicited by UV-inactivated viruses. The response was MOI-dependent and immunoblots confirmed a correlation between luciferase induction and pp72-IE1 expression. Monoclonal antibodies, immune sera and purified immunoglobulin preparations decreased virus-dependent luciferase induction dose-dependently, qualifying this approach as surrogate virus neutralization test. Besides the reduced hands-on time, this assay allows analysis of herpesvirus entry in semi-permissive and non-adherent cells, which were previously non-assessable but play significant roles in herpesvirus pathology.
The Dwarf Spheroidal Companions to M31: WFPC2 Observations of Andromeda III

The Hubble Space Telescope Wide Field Planetary Camera 2 has been used to image Andromeda III, a dwarf spheroidal (dSph) companion to M31. The resulting color-magnitude diagrams (CMDs) reveal for the first time the morphology of the horizontal branch (HB) in this dwarf galaxy. We find that like Andromeda I and Andromeda II, and like most of the Galactic dSph companions, the HB morphology of And III is predominantly red, redder indeed than that of both And I and And II, despite And III having a lower mean metallicity. The And III HB morphology is also somewhat redder than that of the Galactic dSph Draco, which has a similar mean abundance to And III. We interpret this red HB morphology as indicating that the bulk of the And III population is ∼3 Gyr younger than the age of the majority of Galactic globular clusters. Nevertheless, the And III CMD does reveal the presence of a few blue HB stars, and a number of RR Lyrae variables are also evident in the data. This indicates that And III does contain an "old" population of age comparable to that of the Galactic globular clusters. There is no evidence, however, for any young stars in And III despite a claimed association between this dSph and an H I cloud. As was the case for And II, but not And I, no radial gradient was detected in the And III HB morphology. The mean V magnitude of the HB is 25.06 ± 0.04, leading to (m - M)0 = 24.38 ± 0.06 for this dwarf. And III is then ∼75 kpc from the center of M31, comparable to the Galactocentric distances of Sculptor and Draco. Comparison with standard globular cluster red giant branches indicates a mean abundance for And III of ⟨[Fe/H]⟩ = -1.88 ± 0.11, the lowest mean abundance of any of M31's companions. This value, however, is consistent with the absolute magnitude–mean abundance relation followed by dSph galaxies. The same comparison yields an intrinsic abundance dispersion for And III of σint([Fe/H]) = 0.12, a low value compared to And I and And II and to the Galactic dSph's of comparable luminosity to And III. If confirmed by future spectroscopic studies, this low value would suggest that And III retained relatively little of the enrichment products generated during its evolutionary history. The list of candidate variables reveals one definite and one probable anomalous Cepheid variable star in And III. Such variables are common in Galactic dSph's, so their discovery in And III is not unexpected.
Impact of Coronary Artery Bypass Graft Surgery upon Patient ’ s Physical Aspects related to Coronary Artery Diseases at Baghdad Cardiac Centers

As a result of increasing incidence of coronary artery diseases (CAD), the use of coronary artery bypass graft surgery (CABG) has increased. But it still remains that CABG surgery is not a cure for CAD. Many factors are considered to effect the physical aspect in patient’s life as an impact of the surgery. Objective: The study aims to assess the patient’s physical aspects related to coronary artery diseases and to find out the relationship between patients’ physical aspects and their certain demographic characteristics such as ( age, gender, marital status, and smoking). Methodology: A descriptive analytical study was conducted on Non-probability (purposive sample) of (100) patients who had done a coronary artery bypass graft surgery in one of Baghdad cardiac centers (Ibn Al-Bitar specialized center for cardiac surgery and Iraqi center for heart diseases). A questionnaire was used as a tool of data collection for the period of 22 th March to 10 th May 2015. Descriptive statistical analyses were used to analyze the data. Results : The results of the study indicated that (68%) of the study sample were male, their advance age ≤ 60 years (36%), living in rural areas (69%), smokers (80%), approximately (72%) of study sample presented with a history of chronic disease (diabetes mellitus and hypertension), and more than (74%) of the study sample had developed moderate complications that required a (4-6) day period in surgical ward. Conclusions: There was a significant association between patient’s physical aspect and some sociodemographic characteristics (age, marital status, level of education, occupation, and smoking). Recommendations: The study recommended that current strategies used to prevent this problem may not be as effective as previously thought and new approaches are needed to minimize these effects. There is a need to find the suitable CABG model that helps improve patient’s general health and minimize the restricts in his physical activity post-operatively. Designating and distributing a booklet to all patients undergoing CABG surgery filled with instructions pre and post-operative cardiac rehabilitation are recommended.
[Feelings of nursing professionals who work in emergency units].

OBJECTIVE to know the meanings fo the work in an emergency unit for nursing professionals. METHOD qualitative research with phenomenological approach. Data collection was obtained by means of 14 interviews with nursing professionals. RESULTS coexisting feelings of nursing professionals are fatigue, exhaustion, anguish and revolt for the work overload and resources limitations face the situations that involve death risk. CONCLUSION although stress faced by nursing professionals during the daily work, they keep the commitment in assisting with quality and humanization, existing a trend for emotional exhaustion, loss of heart and feelings of anguish, what reaffirms the importance of heath prevention in work environment.