Miracle-dz/UniFAR-FTUs huggingface dataset:
A refined U-Pb age for the Stockholm granite at Frescati, east-central Sweden

ABSTRACT A sample of fine-grained grey Stockholm granite from the Frescati area just north of central Stockholm, east-central Sweden, earlier dated to 1803 +23/−19 Ma by the U-Pb zircon method using TIMS on multigrain fractions, has been reanalyzed using the Nordsim ion microprobe. The new age obtained, 1792±4 Ma, is more precise, and replaces the earlier highly discordant date. It agrees well with other ages for the formation of the Stockholm-type granites and related pegmatites, indicating an age of around 1.79 Ga for this late-orogenic Svecofennian granite magmatism. The Stockholm granite thus formed toward the end of the 1.83–1.79 Ga late Svecofennian metamorphic phase, and crosscuts earlier formed migmatitic gneiss structures in a brittle manner at the present-day level of exposure.
Minimum Achievable Utilization for Fault-Tolerant Processing of Periodic Tasks

The Rate Monotonic Scheduling (RMS) policy is a widely accepted scheduling strategy for real-time systems due to strong theoretical foundations and features attractive to practical uses. For a periodic task set of n tasks with deadlines at the end of task periods, it guarantees a feasible schedule on a single processor as long as the utilization factor of the task set is below n(2/sup 1/n/-1) which converges to 0.69 for large n. We analyze the schedulability of a set of periodic tasks that is scheduled by the RMS policy and is susceptible to a single fault. The recovery action is the reexecution of all uncompleted tasks. The priority of the RMS policy is maintained even during recovery. Under these conditions, we guarantee that no task will miss a single deadline, even in the presence of a fault, if the utilization factor on the processor does not exceed 0.5. Thus, 0.5 is the minimum achievable utilization that permits recovery from faults before the expiration of the deadlines of the tasks. This bound is better than the trivial bound of 0.6912=0.345 that would be obtained if computation times were doubled to provide for reexecutions in the RMS analysis. Our result provides scheduling guarantees for tolerating a variety of intermittent and transient hardware and software faults that can be handled simply by reexecution. In addition, we demonstrate how permanent faults can be tolerated efficiently by maintaining common spares among a set of processors that are independently executing periodic tasks.
Quantitative microsatellite analysis to delineate the commonly deleted region 1p22.3 in mantle cell lymphomas

The molecular pathogenesis of mantle cell lymphomas (MCL), a subset of B‐cell non‐Hodgkin's lymphomas with a poor prognosis, is still poorly understood. In addition to the characteristic primary genetic alteration t(11;14)(q13;q32), several further genetic changes are present in most cases. One of the most frequent genomic imbalances is the deletion of 1p22.1–p31.1 observed in nearly one‐third of MCL cases. This might indicate the presence of tumor suppressor gene(s) in this critical region of deletion. Quantitative microsatellite analysis (QuMA) is a real‐time PCR‐based method to detect DNA copy number changes. Since QuMA has the resolving power to detect subtle genomic alterations, including homozygous deletions, this may help to identify candidate tumor suppressor genes from deleted regions. To gain more insight into the molecular pathogenesis of MCL, QuMA was performed on genomic DNA from 57 MCL cases. Eight microsatellite loci mapping to the chromosomal region 1p22.3 were analyzed. Losses were observed in 51 of the 57 (∼89.5%) samples. Two cases showed a homozygous deletion at the locus containing the gene SH3GLB1, which plays a key role in Bax‐mediated apoptosis. Two hotspots with copy number losses were detected at chromosomal localizations 85.4 and 86.6 Mb encompassing BCL10 and CLCA2. Both the genes seem to be attractive candidates to study tumor suppressor function in MCL. This article contains Supplementary material available at http://www.interscience. wiley.com/jpages/1045–2257/suppmat. © 2006 Wiley‐Liss, Inc.
A neural approach for robot navigation based on cognitive map learning

This paper presents a neural network architecture for a robot learning new navigation behavior by observing a human's movement in a room. While indoor robot navigation is challenging due to the high complexity of real environments and the possible dynamic changes in a room, a human can explore a room easily without any collisions. We therefore propose a neural network that builds up a memory for spatial representations and path planning using a person's movements as observed from a ceiling-mounted camera. Based on the human's motion, the robot learns a map that is used for path planning and motor-action codings. We evaluate our model with a detailed case study and show that the robot navigates effectively.
A controlled clinical trial investigating the effects of cycle ergometry training on exercise tolerance, balance and quality of life in patients with Parkinson’s disease

Purpose: To establish the effect of a 6-week programme of cycle ergometry training on exercise tolerance, balance, activities of daily living (ADL) and quality of life in individuals with Parkinson’s disease (PD). Method: Twenty-three subjects were recruited from the Parkinson’s database of the neurology service in a large urban teaching hospital. Quasi-experimental study of interrupted time-series design was conducted with subjects acting as their own control. Assessments were carried out at baseline, week 7 following the control phase, and week 14 following the intervention phase. Intervention consisted of 30-min cycle ergometry training once weekly. Outcome measures included Six Minute Walk Test, Physiological Cost Index, Berg Balance Scale, Timed Up and Go Test (TUAG), ADL and mobility sections of the Unified Parkinson’s disease Rating Scale (UPDRS) and the Parkinson’s disease questionnaire (PDQ). Results: Statistically significant improvements were noted for the Berg Balance Scale (p = 0.003), TUAG (p = 0.019) and ADL (p = 0.006) and mobility (p = 0.021) sections of the UPDRS. A trend towards improvement was found for exercise tolerance. No significant effect on quality of life was found. Conclusion: A 6-week programme of cycle ergometry training did not significantly influence exercise tolerance in this sample, but improved balance, functional abililty and PD-related disability were noted. Implications for Rehabilitation Individuals with Parkinson’s disease demonstrate lower levels of exercise tolerance than healthy controls. Individuals with Parkinson’s disease could participate in 30 min of cycle ergometry training, with no rest periods required. Cycle ergometry training has a positive effect on balance, function and PD-related disability.
PAC Bandits with Risk Constraints

We study the problem of best arm identiﬁcation with risk constraints within the setting of ﬁxed conﬁdence pure exploration bandits (PAC bandits). The goal is to stop as fast as possible, and with high conﬁdence return an arm whose mean is (cid:15) -close to the best arm among those that satisfy a risk constraint, namely their α -quantile functions are larger than a threshold β . For this risk-sensitive bandit problem, we propose an al-gorithm and prove an upper-bound on its sample complexity for the general case of sub-Gaussian arms’ distributions. We also prove a lower-bound for this general case that shows our derived upper-bound is near-optimal (up to logarithmic factors). Both our upper and lower bounds have similar form to the risk-neutral PAC bandits results of (Even-Dar et al. 2006) and (Mannor and Tsitsiklis 2004), respectively. We also prove a lower-bound for our problem when the arms’ distributions are Gaussian, which is smaller than our general lower-bound, but is stronger in the sense that it applies to any instance of the (Gaussian) problem. This lower-bound is in terms of the KL divergence and has similar behavior to the risk-neutral PAC bandits results of (Kaufmann et al. 2016).
Effects of Integrated Nutrient Management on Potato (Solanum tuberosum L.) Growth, Yield and Yield Components at Haramaya Watershed, Eastern Ethiopia

Potato is an important food security and cash crop in eastern Hararghe Zone. However, the productivity of the crop is constrained by low soil fertility and poor fertilizer management practices. Therefore, a field experiment was conducted at Haramaya watershed in Haramaya District, Eastern Ethiopia; during the 2014 off season using irrigation. The main objective of the study was to assess the effects of integrated nutrient management on potato growth, yield and yield components. The treatments were three rates of farmyard manure (0, 5, 10, t ha﹣1), three rates of N (0, 55.5, 111 kg N ha﹣1), and three rates of phosphorus (0, 46, 92 kg P2O5 ha﹣1). The experiment was laid out as a randomized complete block design in (RCBD) in a factorial arrangement with three replications. The results showed that the effect of integrated use of organic and inorganic fertilizer had significant influence on plant height, above ground biomass, day to maturity, total tuber yield, average tuber number/hill, average tuber mass/hill, marketable tuber number and tuber dry matter yield. The highest marketable tuber yields of 38.65 t ha﹣1 followed by 36.24 t ha﹣1 were obtained in response to a combined application of farm yard manure, N and P at the rates of 10 t FYM ha﹣1 111 kg N ha﹣1 92 kg P2O5 ha﹣1 and 10 ton FYM ha﹣1 111 kg N ha﹣1 46 kg P2O5 ha﹣1, respectively. The marketable and total tuber yields were positively and significantly correlated with all growth and yield components studied but negatively and significantly correlated with the number of main stem/hill, unmarketable tuber yield. In conclusion, application of farm yard manure with, N and P not only significantly improved productivity, but also profitability of the crop.
Convergent Evolution of Chromosomal Sex-Determining Regions in the Animal and Fungal Kingdoms

Sexual identity is governed by sex chromosomes in plants and animals, and by mating type (MAT) loci in fungi. Comparative analysis of the MAT locus from a species cluster of the human fungal pathogen Cryptococcus revealed sequential evolutionary events that fashioned this large, highly unusual region. We hypothesize that MAT evolved via four main steps, beginning with acquisition of genes into two unlinked sex-determining regions, forming independent gene clusters that then fused via chromosomal translocation. A transitional tripolar intermediate state then converted to a bipolar system via gene conversion or recombination between the linked and unlinked sex-determining regions. MAT was subsequently subjected to intra- and interallelic gene conversion and inversions that suppress recombination. These events resemble those that shaped mammalian sex chromosomes, illustrating convergent evolution in sex-determining structures in the animal and fungal kingdoms.
Total intravenous anesthesia vs single pharmacological prophylaxis to prevent postoperative vomiting in children: A systematic review and meta‐analysis

Postoperative nausea and postoperative vomiting are frequent but often missed complications after general anesthesia in pediatric patients. Because inhaled anesthetics are known to trigger postoperative vomiting, total intravenous anesthesia is often administered in high‐risk children to avoid the use of inhalational anesthesia. Since inhalational anesthesia might be advantageous in some situations, the question is raised whether administration of pharmacological prophylaxis offers equal protection from postoperative vomiting compared with total intravenous anesthesia alone.
Reduced risk of colorectal cancer up to 10 years after screening, surveillance, or diagnostic colonoscopy.

BACKGROUND & AIMS Data from randomized controlled trials on the effects of screening colonoscopies on colorectal cancer (CRC) incidence and mortality are not available. Observational studies have suggested that colonoscopies strongly reduce the risk of CRC, but there is little specific evidence on the effects of screening colonoscopies. METHODS We performed a population-based case-control study of 3148 patients with a first diagnosis of CRC (cases) and 3274 subjects without CRC (controls) from the Rhine-Neckar region of Germany from 2003 to 2010. Detailed information on previous colonoscopy and potential confounding factors was collected by standardized personal interviews. Self-reported information on colonoscopies and their indications was validated by medical records. We used multiple logistic regression to assess the association between colonoscopy conducted for specific indications within the past 10 years and risk of CRC. RESULTS A history of colonoscopy was associated with a reduced subsequent risk of CRC, independently of the indication for the examination. However, somewhat stronger associations were found for examinations with screening indications (adjusted odds ratio [OR] 0.09, 95% confidence interval [CI] 0.07-0.13) than for examinations with diagnostic indications, such as positive fecal occult blood test result (OR, 0.33; 95% CI, 0.19-0.57), surveillance after a preceding colonoscopy (OR, 0.33; 95% CI, 0.24-0.45), rectal bleeding (OR, 0.28; 95% CI, 0.20-0.40), abdominal symptoms (OR, 0.15; 95% CI, 0.10-0.21), or other (OR, 0.21; 95% CI, 0.14-0.30). Colonoscopy was also associated with a reduced risk of cancer in the right colon, regardless of the indication, although to a smaller extent than for other areas of the colon (OR for screening colonoscopy, 0.22; 95% CI, 0.14-0.33). CONCLUSIONS In a population-based case-control study, the risk of CRC was strongly reduced up to 10 years after colonoscopy for any indication. Risk was particularly low after screening colonoscopy, even for cancer in the right colon.
Adaptive Control for Nonaffine Nonlinear Systems Using Reliable Neural Network Approximation

This paper presents a once-differentiable control strategy for a class of uncertain nonaffine nonlinear systems based on self-structuring neural networks (SSNNs) approximation, such that the system output tracks the desired trajectory. The optimal weight for each neuron in current SSNN is time-varying signals factually, and current stability analysis is only fit for a dwell time. Current SSNN control laws are not smooth and even not continuous, due to addition or pruning of neurons in the approximation procedure. In this paper, a new SSNN estimator and a new weight update law are proposed to ensure the optimal SSNN weights being constant values and the control law being once-differentiable. The effectiveness of the proposed control law is illustrated by the stability analysis in the whole tracking procedure and shown by the simulation results.
Post‐glacial sediment load and subsidence in coastal Louisiana

Sea level rise in the Gulf of Mexico has occurred at a rate of 1.8–2.2 mm/yr during the 20th century, or nearly the same as observed globally due to combined steric and water mass changes. Tide gauges in coastal Louisiana, however, record a substantially larger rate of rise and while a number of causal mechanisms may be responsible, their specific contribution is poorly understood. Using a realistic viscoelastic Earth model, detailed geologic parameters for south Louisiana and new GPS data, we demonstrate that Holocene sedimentary loading in the Gulf and Mississippi River delta is capable of contributing to 1–8 mm/yr of subsidence over areas of 30–0.75 × 103 km2.
On the isotypic decomposition of cohomology modules of symmetric semi-algebraic sets: polynomial bounds on multiplicities

We consider symmetric (under the action of products of finite symmetric groups) real algebraic varieties and semi-algebraic sets, as well as symmetric complex varieties in affine and projective spaces, defined by polynomials of degrees bounded by a fixed constant $d$. We prove that if a Specht module, $\mathbb{S}^\lambda$, appears with positive multiplicity in the isotypic decomposition of the cohomology modules of such sets, then the rank of the partition $\lambda$ is bounded by $O(d)$. This implies a polynomial (in the dimension of the ambient space) bound on the number of such modules. Furthermore, we prove a polynomial bound on the multiplicities of those that do appear with positive multiplicity in the isotypic decomposition of the above mentioned cohomology modules. We give some applications of our methods in proving lower bounds on the degrees of defining polynomials of certain symmetric semi-algebraic sets, as well as improved bounds on the Betti numbers of the images under projections of (not necessarily symmetric) bounded real algebraic sets, improving in certain situations prior results of Gabrielov, Vorobjov and Zell.
Progress and Challenges in the Search for the Mechanisms of Pulsatile Gonadotropin-Releasing Hormone Secretion

Fertility relies on the proper functioning of the hypothalamic–pituitary–gonadal axis. The hormonal cascade begins with hypothalamic neurons secreting gonadotropin-releasing hormone (GnRH) into the hypophyseal portal system. In turn, the GnRH-activated gonadotrophs in the anterior pituitary release gonadotropins, which then act on the gonads to regulate gametogenesis and sex steroidogenesis. Finally, sex steroids close this axis by feeding back to the hypothalamus. Despite this seeming straightforwardness, the axis is orchestrated by a complex neuronal network in the central nervous system. For reproductive success, GnRH neurons, the final output of this network, must integrate and translate a wide range of cues, both environmental and physiological, to the gonadotrophs via pulsatile GnRH secretion. This secretory profile is critical for gonadotropic function, yet the mechanisms underlying these pulses remain unknown. Literature supports both intrinsically and extrinsically driven GnRH neuronal activity. However, the caveat of the techniques supporting either one of the two hypotheses is the gap between events recorded at a single-cell level and GnRH secretion measured at the population level. This review aims to compile data about GnRH neuronal activity focusing on the physiological output, GnRH secretion.
blaI and blaR1 regulate beta-lactamase and PBP 2a production in methicillin-resistant Staphylococcus aureus

For Staphylococcus aureus, it is hypothesized that two genes located upstream of the beta-lactamase gene, blaZ, are required for the inducible expression of beta-lactamase. blaR1 is predicted to encode a signal-transducing membrane protein, and blaI is predicted to encode a repressor protein. These same two genes may also regulate the production of penicillin-binding protein 2a (PBP 2a), a protein essential for expression of methicillin resistance. To confirm that these two genes encode products that can control both beta-lactamase and PBP 2a production, blaI, blaR1, and blaZ with a 150-nucleotide deletion at the 3' end were subcloned from a 30-kb staphylococcal beta-lactamase plasmid and three beta-lactamase-negative strains of methicillin-resistant S. aureus were transformed with the recombinant plasmid containing that insert. The production of PBP 2a and a nonfunctional beta-lactamase was detected by fluorography and by immunoblots with polyclonal antisera directed against each of the proteins. Whereas the parent strains did not produce beta-lactamase and constitutively produced PBP 2a, PBP 2a and a truncated beta-lactamase were now inducible in the transformants. Therefore, two plasmid-derived genes regulate the production of both PBP 2a and beta-lactamase.
Oxidative stress and antioxidant status in beta-thalassemia major: iron overload and depletion of lipid-soluble antioxidants.

Because of continuous blood transfusions, thalassemia patients are subjected to peroxidative tissue injury by the secondary iron overload. In accordance, analysis of serum from 42 beta-thalassemia patients, aged 4 to 40 years, showed that the mean concentrations of conjugated diene lipid hydroperoxides (CD), lipoperoxides evaluated as malondialdehyde/ thiobarbituric acid (MDA/TBA) adducts, and protein carbonyls increased about twofold with respect to control. Ferritin levels were positively correlated with the amount of MDA (r = .41; P = .007) and showed a positive trend with CD (r = .31; P = .07) and protein carbonyls (r = .35; P = .054), as further evidence of the deleterious effects of high tissue iron levels. Marked changes in the antioxidant pattern were also observed in all patients. Evidence is presented of a net drop in the concentration of ascorbate (-44%), vitamin E (-42%), vitamin A(-44%), beta-carotene (-29%), and lycopene (-67%). On the other hand, an increase of uric acid and bilirubin was observed, whereas serum albumin and glutathione were in the normal range in all patients. As a result, the total serum antioxidant potential, measured as trolox equivalent antioxidant capacity appeared significantly decreased by 14%. Serum levels of vitamin E were inversely correlated with ferritin (r = -.45; P = .003), suggesting a major consumption of this antioxidant under iron overload. Nontransferrin bound iron (NTBI) was in the range 4.5 to 54.8 micrograms/dL (mean, 21.8 +/- 13.9). Although NTBI had a positive trend with ferritin (r = .37, P = .03), no clear correlation was found with either MDA or vitamin E. A mild to severe hepatic damage, as assessed by serum transaminases, was shown in 24 of 42 patients. Serum levels of vitamin E (r = -.49, P = .015), vitamin A (r = -.48, P = .016) and lycopene (r = -.47, P = .020), were inversely correlated with the levels of transminases. On the other hand, lipid-soluble antioxidants in thalassemia patients were depleted to the same extent in hepatitis C virus (HCV)-infected (31 subjects) and in HCV-uninfected (10 subjects), while in the normal range in serum from 30 nonthalassemic patients with HCV-related chronic hepatitis. These results point out that the iron-induced liver damage in thalassemia may play a major role in the depletion of lipid-soluble antioxidants. The variations of the parameters evaluated in the present study were not correlated with the age of the patients. Our results suggest that the measurement of peroxidation products, matched with evaluation of antioxidants, may be a simple measure of iron toxicity in thalessemia, in addition to the conventional indices of iron status.
Evidence for nonmigrating tides produced by the interaction between tides and stationary planetary waves in the stratosphere and lower mesosphere

In this work, 11 years (2002–2012) of Thermosphere, Ionosphere, Mesosphere Energetics, and Dynamics/Sounding of the Atmosphere using Broadband Emission Radiometry (SABER) global temperature data are used to study the nonlinear interaction between stationary planetary waves (SPWs) and tides in the stratosphere and mesosphere. The holistic behavior of the nonlinear interactions between all SPWs and tides is analyzed from the point of view of energetics. The results indicate that the intensities of nonmigrating diurnal, semidiurnal, terdiurnal, and 6 h tides are strongest during winter and almost vanish during summer, synchronous with SPW activity. Temporal correlations between the SPWs and nonmigrating tides for these four tidal components are strong in the region poleward of 20° and below about 80 km. In the tropics, where the SPWs are very weak in all seasons, the correlations are small. Bispectral analysis between triads of waves and tides shows which particular interactions are likely to be responsible for the generation of the nonmigrating tides that are largest in the midlatitude stratosphere. Based on the more limited SABER observations at high latitudes, the correlations there are similar to those in midlatitudes during spring, summer, and autumn; there are no high‐latitude observations by SABER in winter. These results show that nonlinear interactions between SPWs and tides in the stratosphere and the lower mesosphere may be an important source of the nonmigrating tides that then propagate into the upper mesosphere and lower thermosphere.