Miracle-dz/UniFAR-FTUs huggingface dataset:
Volcanic Radiative Forcing From 1979 to 2015

Using volcanic sulfur dioxide emissions in an aerosol‐climate model, we derive a time series of global‐mean volcanic effective radiative forcing (ERF) from 1979 to 2015. For 2005–2015, we calculate a global multiannual mean volcanic ERF of −0.08 W/m2 relative to the volcanically quiescent 1999–2002 period, due to a high frequency of small‐to‐moderate‐magnitude explosive eruptions after 2004. For eruptions of large magnitude such as 1991 Mt. Pinatubo, our model‐simulated volcanic ERF, which accounts for rapid adjustments including aerosol perturbations of clouds, is less negative than that reported in the Intergovernmental Panel on Climate Change (IPCC) Fifth Assessment Report (AR5) that only accounted for stratospheric temperature adjustments. We find that, when rapid adjustments are considered, the relation between volcanic forcing and volcanic stratospheric optical depth (SAOD) is 13–21% weaker than reported in IPCC AR5 for large‐magnitude eruptions. Further, our analysis of the recurrence frequency of eruptions reveals that sulfur‐rich small‐to‐moderate‐magnitude eruptions with column heights ≥10 km occur frequently, with periods of volcanic quiescence being statistically rare. Small‐to‐moderate‐magnitude eruptions should therefore be included in climate model simulations, given the >50% chance of one or two eruptions to occur in any given year. Not all of these eruptions affect the stratospheric aerosol budget, but those that do increase the nonvolcanic background SAOD by ~0.004 on average, contributing ~50% to the total SAOD in the absence of large‐magnitude eruptions. This equates to a volcanic ERF of about −0.10 W/m2, which is about two thirds of the ERF from ozone changes induced by ozone‐depleting substances.
Androgen receptor expression in male breast cancer predicts inferior outcome and poor response to tamoxifen treatment.

OBJECTIVE Androgen receptor (AR) plays an important role in male breast cancer (MBC). Additionally, endocrine therapy is the most important treatment in oestrogen receptor (ER)-positive advanced breast cancer. This study was aimed to investigate the role of AR in MBC treatment and prognosis and to analyse the relationship between AR and the effect of tamoxifen treatment in MBC patients. METHODS AR protein levels and other tumour characteristics (e.g. expression of ER (ESR1), PR (PGR), AR, HER2 (ERBB2) and Ki-67 (MKI67)) in breast cancer tissue from 102 MBC patients were determined using immunohistochemical analysis. Additionally, the relationship between AR status and clinicopathological features was analysed using the χ(2)-test. Association with survival was initially analysed using the Kaplan-Meier method and the log-rank test, and Cox regression analysis was used to adjust for other prognostic indicators. RESULTS High expression of AR was not correlated with T-stage, histological grade, HER2 status and the status of other sex hormone receptors, but was associated with lymph node metastases (P=0.032). AR-positive patients showed significantly shorter 5-year overall survival (OS) rates (P=0.045) and 5-year disease-free survival (DFS) rates (P=0.026) than AR-negative patients. By contrast, for patients who received tamoxifen therapy, AR-negative patients showed a higher clinical benefit rate than AR-positive patients (P=0.025). Additionally, the median TTP and OS were significantly different (P=0.02 for TTP; P=0.029 for OS). CONCLUSIONS AR expression correlates strongly with both OS and DFS in patients with MBC. AR-positive patients can predict a poorer clinical outcome than AR-negative patients after adjuvant tamoxifen therapy.
Theory Driven Hints in the Cheap Necklace Problem: A Preliminary Investigation

In this paper we conducted three experiments using the cheap necklace problem, which is regarded as an insight problem. The effects of two hints derived from two contemporary theoretical accounts of insight—Criterion for Satisfactory Progress theory (CSP) and Representational Change Theory (RCT)—were investigated. In Experiment 1, 78 participants made a single attempt at the problem, and significantly fewer participants given the CSP hint used an incorrect (maximizing) first move than participants given the RCT hint or control participants given no hint, Fisher’s exact test for 2x3 table, p = . 029, with an approximation in χ² effect size, phi = . 340. Experiment 2 explored the performance of 60 participants in the same hint conditions over ten problem-solving trials. The number of trials to solution was significantly fewer in the CSP hint condition than in the control condition, t(30) = 2.23, p = . 033, η² = . 14; this was not so for the RCT hint condition, t(30) = . 44, p = . 666, η² = . 006. Furthermore, there were significantly fewer incorrect (maximizing) first moves in the CSP hint condition than in the other two conditions, F(2, 59) = 15.31, p < . 001, η² = . 35. The CSP hint here appears to promote the exploration of the problem space, such that the correct move may be found. The lack of effect of the RCT hint suggests in preliminary fashion that representational change may not be the primary cognitive process required to solve the cheap necklace problem. However, in Experiment 3 with 110 participants, the CSP and RCT hints were combined yielding a 75% solution rate over a 34.88% solution rate in the control condition, χ²(1) = 16.03, p < . 001, phi = . 402. This result indicates that perhaps aspects from both theories are employed during the problem solving process.
Reinforcement learning of coordination in cooperative multi-agent systems

We report on an investigation of reinforcement learning techniques for the learning of coordination in cooperative multi-agent systems. Specifically, we focus on a novel action selection strategy for Q-learning (Watkins 1989). The new technique is applicable to scenarios where mutual observation of actions is not possible.To date, reinforcement learning approaches for such <i>independent </i> agents did not guarantee convergence to the optimal joint action in scenarios with high miscoordination costs. We improve on previous results (Claus & Boutilier 1998) by demonstrating empirically that our extension causes the agents to converge almost always to the optimal joint action even in these difficult cases.
M2 muscarinic receptor contributes to contraction of the denervated rat urinary bladder.

In vitro bladder contractions in response to cumulative carbachol doses were measured in the presence of selective muscarinic antagonists from rats that had their major pelvic ganglion bilaterally removed. Denervation induced both hypertrophy and a supersensitivity of the bladders to agonist. The affinities in control bladders for antagonism of carbachol-induced contractions were consistent with M3-mediated contractions. Affinities in denervated bladders for 4-diphenlacetoxy- N-methylpiperidine methiodide (8.5) and p-fluoro hexahydrosilodifenidol (6.6) were consistent with M2-mediated contractions, although the methoctramine affinity (6.5) was consistent with M3-mediated contractions. Subtype-selective immunoprecipitation of muscarinic receptors revealed a 50% increase in total and a 60% increase in M2 receptor density with no change in M3 receptor density in denervated bladders compared with normal or sham-operated controls. This increase in M2 receptor density is consistent with the change in affinity of the antagonists for inhibition of carbachol-induced contractions and may indicate that M2 receptors or a combination of M2 and M3 receptors directly mediates smooth muscle contraction in the denervated bladder.
Patterned variation in murine MHC promoters

To compare variation in regulatory and coding DNA, promoter sequences have been obtained from wild-derived mice and laboratory rats. The sequences are from the proximal promoter of the H2Aa, H2Ab, H2Eb, and H2K genes of 24 wild-derived inbred strains and a sample of the corresponding exon 2 sequences and of the RT1.Ba gene of six strains of laboratory rat. They reveal a high level of variation in the mouse MHC class II promoters (H2A and H2E), a low level in MHC class I (H2K), and none in the rat. The variation is pronounced in and around the cAMP response element, a major binding site for modulating promoter activity in response to external stimulation. This finding, together with the different levels of variation in MHC classes I and II, is suggestive of natural selection. However, selection operating via the MHC coding sequences must also contribute, as indicated by the minimal variation in both the MHC class II promoter and coding sequences of the rat. Furthermore CIITA (trans-activator of class II) of the mouse has been reported to have minimal variation in its promoter and none in its coding sequence. Taken together these data suggest that the regulatory and coding sequences undergo coselection. Each of the mouse class II promoters has a pattern of variation that appears to be basically dimorphic, with further variation added by recombination/mutation. The dimorphic allelic lineages are in marginally detectable linkage disequilibrium with the exon 2 sequences, particularly in H2Aa, thus lending further support to the coevolution hypothesis.
Development of a Novel Yeast Cell-Based System for Studying the Aggregation of Alzheimer’s Disease-Associated Aβ Peptides in vivo

Alzheimer’s disease is the most common neurodegenerative disease, affecting ∼50% of humans by age 85. The disease process is associated with aggregation of the Aβ peptides, short 39–43 residue peptides generated through endoproteolytic cleavage of the Alzheimer’s precursor protein. While the process of aggregation of purified Aβ peptides in vitro is beginning to be well understood, little is known about this process in vivo. In the present study, we use the yeast Saccharomyces cerevisiae as a model system for studying Aβ-mediated aggregation in an organism in vivo. One ofthis yeast’s endogenous prions, Sup35/[PSI+], loses the ability to aggregate when the prion-forming domain of this protein is deleted. We show that insertion of Aβ peptide sequences in place of the original prion domain of this protein restores its ability to aggregate. However, the aggregates are qualitatively different from [PSI+] prions in their sensitivity to detergents and in their requirements on trans-acting factors that are normally needed for [PSI+] propagation. We conclude that we have established a useful new tool for studying the aggregation of Aβ peptides in an organism in vivo.
A Review on the Western North Pacific Monsoon: Synoptic-to-Interannual Variabilities

In this paper we review the observed structure and evolution characteristics of the western North Pacific monsoon on various time scales, including its annual cycle, synoptic wave activity, intraseasonal oscillations, and interannual variabilities. On the synoptic (2-10-day) timescale, summertime synoptic waves and equatorial symmetric and anti-symmetric modes are often observed, and they may be responsible for triggering tropical cyclone genesis. On the intraseasonal scale, there are significant spectrum peaks at bi-weekly (10-20-day) and lower-frequency (20-70-day) bands. On the interannual time scale, the monsoon is greatly modulated by and possibly feeds back to the El Nino-Southern Oscillation (ENSO). The paper reviews our current understanding of physical mechanisms that give rise to the synoptic-scale, intraseasonal and interannual variabilities, and multi- scale interactions among these motions. The comparison between the Indian monsoon and the western North Pacific monsoons in terms of their differences in precipitation and circulation patterns, dominant time scales, and global teleconnection is also illustrated. Finally we discuss some remaining issues related to the western North Pacific monsoon variabilities.
Performance Evaluation of Non-Orthogonal Multiple Access in Visible Light Communication

In this paper, the performance of non-orthogonal multiple access (NOMA) is characterized in a downlink visible light communication system for two separate cases. In the case of guaranteed quality of service (QoS) provisioning, we derive an analytical expression of the system coverage probability and show the existence of optimal power allocation coefficients on two-user paired NOMA. In the case of opportunistic best-effort service provisioning, we formulate a closed-form expression of the ergodic sum rate, which is applicable for arbitrary power allocation strategies. The probability that NOMA achieves higher individual rates than OMA is derived. Also, we give an upper bound of the sum rate gain of NOMA over OMA in the high signal-to-noise ratio regime. Both the theoretical and simulation results prove that the performance gain of NOMA over OMA can be further enlarged by pairing users with distinctive channel conditions. We also find out that the choice of light emitting diodes (LEDs) have a significant impact on the system performance. In the case of guaranteed QoS provisioning, the LEDs with larger semi-angles have better performance; while in the case of opportunistic best-effort service provisioning, the LEDs with 35° semi-angle give nearly optimal performance.
Integrating Sample-Based Planning and Model-Based Reinforcement Learning

Recent advancements in model-based reinforcement learning have shown that the dynamics of many structured domains (e.g. DBNs) can be learned with tractable sample complexity, despite their exponentially large state spaces. Unfortunately, these algorithms all require access to a planner that computes a near optimal policy, and while many traditional MDP algorithms make this guarantee, their computation time grows with the number of states. We show how to replace these over-matched planners with a class of sample-based planners — whose computation time is independent of the number of states — without sacrificing the sample-efficiency guarantees of the overall learning algorithms. To do so, we define sufficient criteria for a sample-based planner to be used in such a learning system and analyze two popular sample-based approaches from the literature. We also introduce our own sample-based planner, which combines the strategies from these algorithms and still meets the criteria for integration into our learning system. In doing so, we define the first complete RL solution for compactly represented (exponentially sized) state spaces with efficiently learnable dynamics that is both sample efficient and whose computation time does not grow rapidly with the number of states.
Temperature 1 self-assembly: deterministic assembly in 3D and probabilistic assembly in 2D

We investigate the power of the Wang tile self-assembly model at temperature 1, a threshold value that permits attachment between any two tiles that share even a single bond. When restricted to deterministic assembly in the plane, no temperature 1 assembly system has been shown to build a shape with a tile complexity smaller than the diameter of the shape. In contrast, we show that temperature 1 self-assembly in 3 dimensions, even when growth is restricted to at most 1 step into the third dimension, is capable of simulating a large class of temperature 2 systems, in turn permitting the simulation of arbitrary Turing machines and the assembly of n x n squares in near optimal O(log n) tile complexity. Further, we consider temperature 1 probabilistic assembly in 2D, and show that with a logarithmic scale up of tile complexity and shape scale, the same general class of temperature τ = 2 systems can be simulated, yielding Turing machine simulation and O(log2 n) assembly of n x n squares with high probability. Our results show a sharp contrast in achievable tile complexity at temperature 1 if either growth into the third dimension or a small probability of error are permitted. Motivated by applications in nanotechnology and molecular computing, and the plausibility of implementing 3 dimensional self-assembly systems, our techniques may provide the needed power of temperature 2 systems, while at the same time avoiding the experimental challenges faced by those systems.
Growth and Endogenous Political Institutions

In this paper we study the dynamics of political institutions and the different public policies they imply. While political institutions are influenced by economic development, they are in turn a key determinant of the development process. In particular, democratic institutions implement different public policies than oligarchies, and therefore imply different economic outcomes. Economic development in turn increases the likelihood of transitions from oligarchy to democracy because it changes the relative costs for and benefits from the public policies arising under democratic regimes. We show that different scenarios of political development can arise endogenously: democratic transitions under the shadow of social conflict and democratic transitions initiated by the oligarchic elite. Moreover, we show that democratic regimes tend to provide more efficient public policies, and more redistribution than oligarchic regimes. The results are compared to historical and empirical evidence, and the consequences of the simplifying assumptions are discussed in detail.
Pathologic Response Rates of Gemcitabine/Cisplatin versus Methotrexate/Vinblastine/Adriamycin/Cisplatin Neoadjuvant Chemotherapy for Muscle Invasive Urothelial Bladder Cancer

Objectives. To compare pathologic outcomes after treatment with gemcitabine and cisplatin (GC) versus methotrexate, vinblastine, adriamycin, and cisplatin (MVAC) in the neoadjuvant setting. Methods. Data was retrospectively collected on 178 patients with T2-T4 bladder cancer who underwent radical cystectomy between 2003 and 2011. Outcomes of interest included those with complete response (pT0) and any response (≤pT1). Odds ratios were calculated using multivariate logistic regression. Results. Compared to those who did not receive neoadjuvant chemotherapy, there were more patients with complete response (28% versus 9%, OR 3.11 (95% CI: 1.45–6.64), P = 0.03) and any response (52% versus 25%, OR 3.23 (95% CI: 1.21–8.64), P = 0.01). Seventy-two patients received GC (n = 41) or MVAC (n = 31). CR was achieved in 29% and 22% of GC and MVAC patients, respectively (multivariate OR 0.39, 95% CI 0.10–1.58). Any response (≤pT1) was achieved in 56% of GC and 45% of MVAC patients (multivariate OR 0.45, 95% CI 0.12–1.71). Conclusions. We observed similar pathologic response rates for GC and MVAC neoadjuvant chemotherapy in this cohort of patients with muscle invasive urothelial cancer (MIBC). Our findings support the use of GC as an alternative regimen in the neoadjuvant setting.
Replication Data for: Climate smart agriculture rapid appraisal (CSA-RA): A tool for prioritizing context-specific climate smart agriculture technologies

Approaches that aim to identify and prioritize locally appropriate climate smart agriculture (CSA) technologies will need to address the context-specific multi-dimensional complexity in agricultural systems. The climate smart agriculture rapid appraisal (CSA-RA) is a mixed method approach that draws on participatory bottom-up, qualitative, and quantitative tools to assess the heterogeneity of local contexts, and prioritize context-specific CSA options. This is an imperative if countries are to respond to the COP21 agreement and meet their intended nationally determined contributions (INDCs). The CSA-RA is designed to assess biophysical including climatic, socio-cultural, economic and technological characteristics at the household, farm and community/regional level. The CSA-RA employs gender-disaggregated methods, including gender differences in perceptions of climate change and its impacts. The CSA-RA combines common participatory rural appraisal (PRA) and rapid rural appraisal (RRA) tools into one methodology, that disaggregates the gender dimension, and includes resource mapping; climate calendars; historical calendars; cropping calendars; organization mapping; transect walks; key informant interviews; farmer interviews; and pairwise ranking matrix. The tool collects qualitative and quantitative data from various stakeholders (farmers, local leaders, researchers, local-level agricultural experts, private sector actors, donor organizations, and policy implementers), allowing expansive analysis, triangulation and validation. Application of the CSA-RA in Tanzania and Uganda reveals heterogeneity across the sites in terms of vulnerability, constraints and CSA priorities among different social groups (gender) and agro-ecological zones. Thus, the CSA-RA allows stakeholders to simultaneously take into account biophysical and socio-economic aspects to target and implement CSA.
The integration of computerised accounting in the accounting curriculum as an educational learning curve for students entering the business world

At universities, educating students on real-life practices is one of the key drivers in a changing academic environment. Academic institutions encourage the study of the learning environment and ensure that appropriate strategies are in place for educating students. A first-year Accounting I student stated the importance of computerised accounting: ‘Computerised accounting is used in the workplace and therefore using it in varsity, grants students a view on how things will be after completion of their respective degrees. ’ Accordingly, the purpose of this study was to empirically investigate the perceived acquisition of information technology (IT) knowledge and determine the skills required for students to convert the knowledge gained into actions as a learning curve for accounting students entering the business world. The results indicated that students’ knowledge of Accounting I increased with the integration of computerised Accounting in the Accounting I Curriculum.
T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines

Analysis of the cDNA encoding murine interleukin (IL) 17 (cytotoxic T lymphocyte associated antigen 8) predicted a secreted protein sharing 57% amino acid identity with the protein predicted from ORF13, an open reading frame of Herpesvirus saimiri. Here we report on the cloning of human IL-17 (hIL-17), the human counterpart of murine IL-17. hIL-17 is a glycoprotein of 155 amino acids secreted as an homodimer by activated memory CD4+ T cells. Although devoid of direct effects on cells of hematopoietic origin, hIL-17 and the product of its viral counterpart, ORF13, stimulate epithelial, endothelial, and fibroblastic cells to secrete cytokines such as IL-6, IL-8, and granulocyte-colony- stimulating factor, as well as prostaglandin E2. Furthermore, when cultured in the presence of hIL-17, fibroblasts could sustain the proliferation of CD34+ hematopoietic progenitors and their preferential maturation into neutrophils. These observations suggest that hIL-17 may constitute (a) an early initiator of the T cell-dependent inflammmatory reaction; and (b) an element of the cytokine network that bridges the immune system to hematopoiesis.