Miracle-dz/UniFAR-FTUs huggingface dataset:
Coping with a national trauma: A nationwide longitudinal study of responses to the terrorist attacks of September 11.

The terrorist attacks of September 11, 2001, exposed every person in the USA to an experience that, in recent decades, was unprecedented in its scope and traumatic impact. Perhaps over 100,000 individuals directly witnessed these events, and many others viewed the attacks and their aftermath via the media (Yehuda, 2002). It has been argued that this national trauma “influenced and will continue to influence the clinical presentation of patients seeking health care services” in the USA (Yehuda, 2002, p. 108). A wide range of responses can be expected following traumatic life events. Research conducted after the Oklahoma City, OK, bombing indicates that responses to a terrorist attack are likely to be highly variable (North et al. , 1999). Research in the broader field of stress and coping has also demonstrated considerable variability in emotional and cognitive responses to stressful experiences (Silver & Wortman, 1980;Wortman & Silver, 1989, 2001). Despite advances in understanding reactions to traumatic events, our understanding of responses to community-level events in general, and terror attacks in particular, is limited. Progress in understanding the social and psychological process following such occurrences requires examination of how responses to a variety of stressful events are similar and different at both the group and individual level. Research has matured to the point that large-scale, prospective, longitudinal studies with the scope to examine mediators and moderators of adjustment processes are not only possible, but also necessary (North & Pfefferbaum, 2002). Moreover, the threat of future terrorist attacks demands that a higher level of urgency and research sophistication be directed not only at understanding the effects of such attacks, but also at the individual and social variables that predict psychological outcomes to such events over time.
The crystal structure of 8-amino-7-oxononanoate synthase: a bacterial PLP-dependent, acyl-CoA-condensing enzyme.

8-Amino-7-oxononanoate synthase (or 8-amino-7-ketopelargonate synthase; EC 2.3.1.47; AONS) catalyses the decarboxylative condensation of l-alanine and pimeloyl-CoA in the first committed step of biotin biosynthesis. We have cloned, over-expressed and purified AONS from Escherichia coli and determined the crystal structures of the apo and PLP-bound forms of the enzyme. The protein is a symmetrical homodimer with a tertiary structure and active site organisation similar to, but distinct from, those of other PLP-dependent enzymes whose three-dimensional structures are known. The critical PLP-binding lysine of AONS is located at the end of a deep cleft that allows access of the pantothenate arm of pimeloyl-CoA. A cluster of positively charged residues at the entrance to this cleft forms a putative diphosphate binding site for CoA. The structure of E. coli AONS enables identification of the key residues of the PLP-binding site and thus provides a framework with which to understand the biochemical mechanism, which is similar to that catalysed by 5-aminolevulinate synthase and two other alpha-oxoamine synthases. Although AONS has a low overall sequence similarity with the catalytic domains of other alpha-oxoamine synthases, the structure reveals the regions of significant identity to be functionally important. This suggests that the organisation of the conserved catalytic residues in the active site is similar for all enzymes of this sub-class of PLP-dependent enzymes and they share a common mechanism. Knowledge of the three-dimensional structure of AONS will enable characterisation of the structural features of this enzyme sub-family that are responsible for this important type of reaction.
Cilostazol could ameliorate platelet responsiveness to clopidogrel in patients undergoing primary percutaneous coronary intervention.

BACKGROUND Cilostazol increases the cyclic adenosine monophosphate levels in platelets and might ameliorate the antiplatelet activity of clopidogrel. This study investigated the additional effect of cilostazol on platelet aggregation measured by a VerifyNow analyzer and soluble CD40 ligand (sCD40L) as a marker of activated platelet in patients undergoing primary percutaneous coronary intervention (PCI). METHODS AND RESULTS Sixty cases of primary PCI were randomly assigned to dual (aspirin and clopidogrel) or triple (dual plus cilostazol) therapy. The antiplatelet effects of aspirin and clopidogrel were evaluated by VerifyNow tests. The plasma sCD40L levels at admission, 24 h and 21 days were measured by the ELISA method. The arachidonic acid induced platelet aggregation was similar in both groups. However, the triple group had a significantly lower P2Y12 reaction unit (dual 208.8+/-69.0 vs triple 168.2+/-79.2, p=0.041) and higher % inhibition of adenosine diphosphate (ADP)-induced platelet aggregation (dual 23.8+/-21.4% vs triple 40.5+/-21.0%, p=0.004). In the multivariate analysis, cilostazol was a negative predictor for low responders to clopidogrel (95% confidence interval 0.067-0.711). The plasma sCD40L levels were not significantly different between the 2 groups at the same point of time. CONCLUSIONS The addition of cilostazol to the combination of aspirin plus clopidogrel significantly increases the inhibition of ADP-induced platelet aggregation. However, there was no additive effect on aspirin-induced antiplatelet activity or lowering of sCD40L.
DCU-SEManiacs at SemEval-2016 Task 1: Synthetic Paragram Embeddings for Semantic Textual Similarity

We experiment with learning word representations designed to be combined into sentence level semantic representations, using an objective function which does not directly make use of the supervised scores provided with the training data, instead opting for a simpler objective which encourages similar phrases to be close together in the embedding space. This simple objective lets us start with high quality embeddings trained using the Paraphrase Database (PPDB) (Wieting et al., 2015; Ganitkevitch et al., 2013), and then tune these embeddings using the official STS task training data, as well as synthetic paraphrases for each test dataset, obtained by pivoting through machine translation. Our submissions include runs which only compare the similarity of phrases in the embedding space, directly using the similarity score to produce predictions, as well as a run which uses vector similarity in addition to a suite of features we investigated for our 2015 Semeval submission. For the crosslingual task, we simply translate the Spanish sentences to English, and use the same system we designed for the monolingual task.
Robust and Sparse Fuzzy K-Means Clustering

The partition-based clustering algorithms, like K-Means and fuzzy K-Means, are most widely and successfully used in data mining in the past decades. In this paper, we present a robust and sparse fuzzy K-Means clustering algorithm, an extension to the standard fuzzy K-Means algorithm by incorporating a robust function, rather than the square data fitting term, to handle outliers. More importantly, combined with the concept of sparseness, the new algorithm further introduces a penalty term to make the object-clusters membership of each sample have suitable sparseness. Experimental results on benchmark datasets demonstrate that the proposed algorithm not only can ensure the robustness of such soft clustering algorithm in real world applications, but also can avoid the performance degradation by considering the membership sparsity.
Effects of “Teaching Method Workshop” on general surgery residents’ teaching skills

Introduction: Residents have an important role as teachers and need to know about teaching, teaching methods and skills. In developed countries, “resident-as-teacher” programs have been implemented progressively; but there is little information about this theme in developing countries such as Iran. This study aimed to determine effects of “teaching method” workshop on surgical residents’ teaching skills in Isfahan University of Medical Sciences. Materials and Methods: In this quasi-experimental study, 18 residents in 1st, 2nd, and 3rd years of surgical residency in Isfahan University of Medical Sciences have attended in a 10-hour workshop. Two questionnaires (validity and reliability) was verified: Clinical teaching self-assessment and clinical teaching evaluation was completed before and after the intervention (“teaching method” workshop) by attending residents and rater interns, respectively. Paired-samples T-test was used to analyze collecting data. Results: After intervention, Self-assessment mean scores were increased in two categories: feedback from 3.34 to 3.94 (P = 0.011) and promoting self- directed learning from 3.53 to 4.02 (P = 0.009); whereas, there was no significant differences in evaluation mean scores. Conclusion: Statistical results from self-assessment and evaluation scores show little improvement in residents’ teaching skills after the intervention, but residents assessed the workshop as useful. Lack of motivation in interns and little reward for residents who attend in educational activities could be responsible for these results. So, to promote role of residents’ as teachers, we offer revision in residency curriculum and residents’ formal duties as well as designing educational programs in teaching theme based on our needs and resources.
REFRACTIVE OUTCOMES OF PHACOEMULSIFICATION AND INTRAOCULAR LENS IMPLANTATION AFTER PARS PLANA VITRECTOMY

Purpose: To describe the visual acuity outcomes of patients undergoing phacoemulsification and intraocular lens implantation after pars plana vitrectomy, and to compare of refractive errors after phacoemulsification and intraocular lens implantation in the cases of vitrectomized eyes and nonvitrectomized eyes. Methods: The subjects of this study were 45 eyes performed phacoemulsification after vitrectomy from January 2004 to February 2007. Office records were reviewed for best-corrected visual acuity before and after phacoemulsification. In 45 vitrectomized eyes (Group V) and 50 nonvitrectomized eyes (Group P), we compared the predicted refraction by preoperative data, and actual postoperative refraction of postoperative 2 months. Results: The average interval from pars plana vitrectomy to phacoemulsification was 11.5 months. In Group V, 41 of 45 eyes (91.1%) had improved best-corrected visual acuity more than one line, after phacoemulsification. Although, more hyperopic shift was noted in Group V than Group P, there was no significant difference between the predicted refraction by preoperative data and postoperative manifest refraction in both groups. Conclusion: Phacoemulsification after pars plana vitrectomy showed no significant difference between the predicted refraction by preoperative data and the actual postoperative refraction.
Diagnosis of Periprosthetic Infection: Novel Developments

Abstract The diagnosis of periprosthetic joint infections (PJIs) has traditionally been performed by obtaining a history and physical exam, measuring serology, and performing microbiology analysis of synovial fluid and tissue samples. The measurement of serum biomarkers, such as the erythrocyte sedimentation rate and the C-reactive protein (CRP), is routinely used to diagnose PJI. However, these markers are elevated in all inflammatory conditions, necessitating the need for more specific biomarkers to diagnose PJI. Serum biomarkers such as procalcitonin, interleukin (IL)-6, tumor necrosis factor (TNF)-α, short-chain exocellular lipoteichoic acid, soluble intercellular adhesion molecule-1, and monocyte chemoattractant protein-1 may be more specific to PJI. Synovial fluid biomarkers elevated in PJI include cytokines such as IL-1β, IL-6, IL-8, IL-17, TNF-α, interferon-δ, and vascular endothelial growth factor. More specific synovial fluid biomarkers include synovial CRP, α-defensin, human β-defensin-2 (HBD-2) and HBD-3, leukocyte esterase, and cathelicidin LL-37. These biomarkers are the future for sensitive and specific diagnosis of PJI.
Special Education for Today's Teachers: An Introduction

Part I: Becoming a Professional: What Are the Foundations of Special Education? Chapter 1 Teaching Students with Special Educational Needs: Finding Your Role Chapter 2 Special Education Today: An Unfinished History Part II: Teaching Effectively in the Classroom: What Can You Expect? Chapter 3 Accepting Responsibility for the Learning of All Students: What Does It Mean? Chapter 4 Identification and Planning for Students with Special Needs Chapter 5 Teaching, Learning, and Behavior Management Part III: Meeting the Multiple Needs of Students with Exceptionalities: What Is Effective Practice? Chapter 6 Learning Disabilities Chapter 7 Emotional and Behavioral Disabilities Chapter 8 Mild Intellectual Disabilities Chapter 9 Attention Deficit/Hyperactivity Disorders Chapter 10 Autism Spectrum Disorders Chapter 11 Communication Disorders Chapter 12 Severe Intellectual Disabilities and Multiple Disabilities Chapter 13 Sensory Impairments Chapter 14 Physical Disabilities, Traumatic Brain Injury, and Chronic Health Disorders Chapter 15 Academically Gifted or Talented Part IV: A Successful Career: Growing in Your Profession Chapter 16 Continuing a Successful Career: Professionalism, Collaborative Support, and Personal Development Appendix A PRAXISTM Standards Appendix B Appendix C Glossary. References. Name Index. Subject Index.
Consensus Document of the Italian Association of Hospital Cardiologists (ANMCO), Italian Society of Pediatric Cardiology (SICP), and Italian Society of Gynaecologists and Obstetrics (SIGO): pregnancy and congenital heart diseases

Abstract The success of cardiac surgery over the past 50 years has increased numbers and median age of survivors with congenital heart disease (CHD). Adults now represent two-thirds of patients with CHD; in the USA alone the number is estimated to exceed 1 million. In this population, many affected women reach reproductive age and wish to have children. While in many CHD patients pregnancy can be accomplished successfully, some special situations with complex anatomy, iatrogenic or residual pathology are associated with an increased risk of severe maternal and fetal complications. Pre-conception counselling allows women to come to truly informed choices. Risk stratification tools can also help high-risk women to eventually renounce to pregnancy and to adopt safe contraception options. Once pregnant, women identified as intermediate or high risk should receive multidisciplinary care involving a cardiologist, an obstetrician and an anesthesiologist with specific expertise in managing this peculiar medical challenge. This document is intended to provide cardiologists working in hospitals where an Obstetrics and Gynecology Department is available with a streamlined and practical tool, useful for them to select the best management strategies to deal with a woman affected by CHD who desires to plan pregnancy or is already pregnant.
Forearm vascular responsiveness to alpha 1- and alpha 2-adrenoceptor stimulation in patients with congestive heart failure.

BACKGROUND The alpha-adrenergic component of the sympathetic nervous system plays a major role in the pathophysiology, clinical manifestations, and natural history of human congestive heart failure (CHF). However, the functional integrity of vascular alpha 1- and alpha 2-adrenoceptors in CHF remains to be elucidated. The present study was designed to assess the vascular responsiveness of alpha 1- and alpha 2-adrenoceptors in patients with CHF. METHODS AND RESULTS To evaluate alpha 1- and alpha 2-adrenoceptor responsiveness, we studied the effects of the regional infusion into the brachial artery of increasing doses of phenylephrine (a selective alpha 1-adrenoceptor agonist) and BHT 933 (a selective alpha 2-adrenoceptor agonist) on vascular responses in 12 healthy subjects and in 24 patients with CHF secondary to primary dilated cardiomyopathy or ischemic heart disease. Left ventricular ejection fraction was measured by radionuclide angiography, and forearm blood flow was determined by venous occlusion plethysmography. Phenylephrine reduced forearm blood flow in normal subjects from 5.2 +/- 0.9 to 2.5 +/- 0.6 mL per 100 mL of tissue/min (P < .05) at the highest dose (-50.8 +/- 4.8% versus baseline). A similar vasoconstriction was obtained in patients with CHF (from 3.5 +/- 0.5 to 1.5 +/- 0.2 mL per 100 mL of tissue/min (P < .05) (-58.7 +/- 5.0% versus baseline). The dose-response curves produced by phenylephrine in the two groups were comparable. The highest dose of BHT 933 reduced forearm blood flow in normal subjects from 5.3 +/- 0.9 to 2.3 +/- 0.6 mL per 100 mL of tissue/min (P < .05) (-59.0 +/- 4.9% versus baseline). In patients with CHF, a similar vasoconstriction was obtained (from 4.2 +/- 0.8 to 1.5 +/- 0.3 mL per 100 mL of tissue/min, P < .05, -62.1 +/- 6.5% versus baseline). The dose-response curves produced by BHT 933 also were comparable in the two groups. In patients with CHF, plasma concentrations of norepinephrine were significantly higher than in normal subjects. CONCLUSIONS The results of the present study demonstrate that alpha 1- and alpha 2-adrenoceptor stimulations produced an equivalent vasoconstriction in patients with CHF and in normal subjects. This indicates that the vascular responsiveness to alpha-adrenoceptor agonists may be preserved in the limb vessels of patients with CHF.
Information retrieval and the philosophy of language

L'A. met en avant les implications de la philosophie du langage pour la recherche d'information, notamment en ce qui concerne les difficultes de la description des contenus intellectuels. Les echecs du processus de recherche d'information sur le plan linguistique se situent aux niveaux de la description et de la discrimination, et dans l'equilibre entre resultat (recall) et precision. L'A. rappelle l'impact des travaux de L. Wittgenstein sur la theorie du langage et plus particulierement sur le sens linguistique : les mots nomment des objets, chaque mot a un sens, le sens d'un mot est independent du contexte, le sens des phrases est constitue du sens des mots. La theorie externaliste des echaffaudages (scaffolding) devrait avoir un impact important sur la description et la classification en recherche d'information. La part de la philosophie du langage dans la litterature sur la recherche d'information demeure toutefois modeste.
Structure of the Leanyer orthobunyavirus nucleoprotein–RNA complex reveals unique architecture for RNA encapsidation

Negative-stranded RNA viruses cover their genome with nucleoprotein (N) to protect it from the human innate immune system. Abrogation of the function of N offers a unique opportunity to combat the spread of the viruses. Here, we describe a unique fold of N from Leanyer virus (LEAV, Orthobunyavirus genus, Bunyaviridae family) in complex with single-stranded RNA refined to 2.78 Å resolution as well as a 2.68 Å resolution structure of LEAV N–ssDNA complex. LEAV N is made up of an N- and a C-terminal lobe, with the RNA binding site located at the junction of these lobes. The LEAV N tetramer binds a 44-nucleotide-long single-stranded RNA chain. Hence, oligomerization of N is essential for encapsidation of the entire genome and is accomplished by using extensions at the N and C terminus. Molecular details of the oligomerization of N are illustrated in the structure where a circular ring-like tertiary assembly of a tetramer of LEAV N is observed tethering the RNA in a positively charged cavity running along the inner edge. Hydrogen bonds between N and the C2 hydroxyl group of ribose sugar explain the specificity of LEAV N for RNA over DNA. In addition, base-specific hydrogen bonds suggest that some regions of RNA bind N more tightly than others. Hinge movements around F20 and V125 assist in the reversal of capsidation during transcription and replication of the virus. Electron microscopic images of the ribonucleoprotein complexes of LEAV N reveal a filamentous assembly similar to those found in phleboviruses.
[Depressive symptoms and health service utilisation among persons 50 years or older in Germany. A population-based cross-sectional study].

OBJECTIVE To examine the association between depressive symptoms and the use of health services among people aged 50 years or older in Germany. METHODS Data came from the German subsample of the "Survey of Health, Ageing and Retirement in Europe (SHARE)", comprising a nationally representative sample of 2890 German residents aged 50 years or older (mean age 65 years, 55 % women). The cross-sectional association between depressive symptoms (EURO-D scale ≥ 4 points) and health service use was examined by multivariable regression analysis. RESULTS Depressive symptoms were found in 21 % of respondents and were associated with a higher utilisation of health care services (odds ratio [OR] 2.3, 95 % confidence interval [CI] 1.2 - 4.3) and social care services (OR 2.6, 95 % CI 1.5 - 4.7) even after adjusting for sociodemographic and psychosocial factors, cognitive function and indicators of physical health. CONCLUSION Participants with depressive symptoms had a higher service utilisation independent of somatic comorbidity and other potential confounders.
Researching Theories of Crime and Deviance

1. Introduction 2. Rational Choice/Deterrence Theory 3. Trait Theories 4. Social Disorganization Theory 5. Anomie/Strain Theory 6. Social Learning Theory 7. Social Control Theory 8. Labeling Theory 9. Conflict Theory 10. Integrated Theory 11. Conclusion
Matching Vector Codes

A locally decodable code encodes a message by a codeword, such that even if the codeword is corrupted by noise, each message bit can be recovered with high probability by a randomized decoding procedure that reads only few bits of the codeword. Recently a new class of locally decodable codes, based on families of vectors with restricted dot products has been discovered. We refer to those codes as Matching Vector (MV) codes. In this work we develop a new view of MV codes and uncover certain similarities between them and classical Reed Muller codes. Our view allows us to obtain a deeper insight into the power and limitations of MV codes. We use it to construct codes that can tolerate more errors or are shorter than previously known codes for certain parameter settings. We also show super-linear lower bounds on the codeword length of any MV code.
A crossed-domain sentiment analysis system for the discovery of current careers from social networks

In recent years, the sentiment analysis on data messages from social networks has attracted high attention of researchers. However, most of their works have been focused on classifying user messages to positive (or like) and negative (or dislike) on social issues or discussion topics. In addition, they usually only worked with English messages from a single data source, or a domain. In this paper, we proposed a crossed-domain sentiment analysis system for the discovery of current careers from social networks. The proposed system can capture sentiment of career-related messages from two famous social networks, including Twitter and Facebook. The experimental results clearly pointed out that the most favorite careers which enjoy the highest positive sentiment and the least favorite careers that have the highest negative sentiment. The performance results of the proposed system are promising for crossed-domain sentiment analysis, with the precision of over 85% and the recall of over 90%.