Miracle-dz/UniFAR-FTUs huggingface dataset:
Dynamic Evaluation of Job Search Assistance

This paper evaluates a job search assistance program for unemployment insurance recipients. The assignment to the program is dynamic. We provide a discussion on dynamic treatment effects and identification conditions. In the empirical analyses we use administrative data from a unique institutional environment. This allows us to compare different microeconometric evaluation estimators. All estimators find that the job search assistance program reduces the exit to work, in particular when provided early during the spell of unemployment. Furthermore, continuous-time (timing-of-events and regression discontinuity) methods are more robust than discrete-time (propensity score and regression discontinuity) methods.
Towards an Ecological Perspective on Age–Performance Relations

The layperson’s view associates aging with biological and cognitive losses, which could be associated with decrements in work productivity and overall contributions to society. In turn, ecological approaches to life span development suggest that successful performance can result from an adaptive employment of an individual’s physical, cognitive, or social capital in the appropriate environment. This ecological framework suggests that one must understand the demands of particular ecologies (i.e., niches) to predict whether aging is associated with failure, maintenance, or even improvements in performance. We provide examples that illustrate the importance of an ecological approach to understanding adaptation to challenging decision tasks both in the laboratory and in the wild. Overall, we propose that there are specific strategies and niches that can help older adults thrive and that more work is needed to understand the exact characteristics that lead to good performance in old age.
High Degree of Overlap between Responses to a Virus and to the House Dust Mite Allergen in Airway Epithelial Cells

Background Airway epithelium is widely considered to play an active role in immune responses through its ability to detect changes in the environment and to generate a microenvironment for immune competent cells. Therefore, besides its role as a physical barrier, epithelium affects the outcome of the immune response by the production of various pro-inflammatory mediators. Methods We stimulated airway epithelial cells with viral double stranded RNA analogue poly(I:C) or with house dust mite in a time course of 24 hours. In order to determine cytokines production by stimulated cells, we performed multiplex enzyme linked immunosorbant assay (ELISA). Results We demonstrate that the temporal pattern of the genes that respond to virus exposure in airway epithelium resembles to a significant degree their pattern of response to HDM. The gene expression pattern of EGR1, DUSP1, FOSL1, JUN, MYC, and IL6 is rather similar after viral (poly(I:C)) and HDM exposure. However, both triggers also induce a specific response (e.g. ATF3, FOS, and NFKB1). We confirmed these data by showing that epithelial cells produce a variety of similar mediators in response to both poly(I:C) and HDM challenge (IL1-RA, IL-17, IFN-α and MIP1-α), sometimes with a quantitative difference in response (IL2-R, IL-6, IL-8, MCP-1, MIG, and HGF). Interestingly, only four mediators (IL-12, IP-10, RANTES and VEGF) where up-regulated specifically by poly(I:C) and not by HDM. Additionally, we report that pre-exposure to HDM deregulates production of cytokines and mediators in response to poly(I:C). Conclusions Epithelial cells responses to the HDM-allergen and a virus strongly resemble both in gene expression and in protein level explaining why these two responses may affect each other.
The Illiquidity Puzzle: Theory and Evidence from Private Equity

This paper presents a theory of liquidity where we explicitly model the liquidity of the security as a choice variable, which enables the manager raising the funds to screen for 'deep pocket' investors, i.e. these that have a low likelihood of a liquidity shock. By choosing the degree of illiquidity of the security, the manager can influence the type of investors the firm will attract. The benefit of liquid investors is that they reduce the manager's cost of capital for future fund raising. If inside investors have fewer information asymmetries about the quality of the manager than the outside market, more liquid investors protect the manager from having to return to the outside market, where he would face higher cost of capital due to asymmetric information problems. We test the predictions of our model in the context of the private equity industry. Consistent with the theory, we find that transfer restrictions on investors are less common in later funds organized by the same private equity firm, where information problems are presumably less severe. Contracts involving the close-knit California venture capital community - where information on the relative performance of funds are more readily ascertained - are less likely to employ many of these provisions as well. Also, private equity partnerships whose investment focus is in industries with longer investment cycles display more transfer constraints. For example, funds focusing on the pharmaceutical industry have more constraints, while those specializing in computing and Internet investments have fewer constraints. Finally, we investigate whether the identity of the investors that invest in a private equity fund is related to the transferability of the stakes. We find that transferability constraints are less prevalent when private equity funds have limited partners that are known to have few liquidity shocks, for example endowments, foundations, and other investors with long-term commitments to private equity.
The Impact of Capital-Based Regulation on Bank Risk-Taking☆

Abstract In this paper we model the dynamic portfolio choice problem facing banks, calibrate the model using empirical data from the banking industry for 1984–1993, and assess quantitatively the impact of recent regulatory developments related to bank capital. The model implies a U-shaped relationship between capital and risk-taking: As a bank's capital increases it first takes less risk, then more risk. A deposit insurance premium surcharge on undercapitalized banks induces them to take more risk. An increased capital requirement, whether flat or risk-based, tends to induce more risk-taking by ex-ante well-capitalized banks that comply with the new standard. Journal of Economic Literature Classification Numbers: G20, G28.
Locking Compression Plate in the Treatment of Forearm Fractures: A Prospective Study

Purpose. To evaluate the use of locking compression plates (LCPs) in diaphyseal forearm fractures. Methods. 9 women and 23 men (mean age, 35; range, 12–70 years) with 45 forearm fractures were treated by open reduction and internal fixation with 3.5-mm stainless steel LCPs. All patients were followed up monthly until union; the mean duration being 20 months. Radiographic assessment was performed at 3, 6, 12, and 18 months. Clinical assessments regarding pain and function were undertaken at the final follow-up. Results. Two patients had delayed union but none had nonunion. There was no deep infection and only one superficial infection. Two refractures occurred after implant removal, both were of simple transverse type and at the sites of the original fractures. 33% of the fractures were reduced anatomically. 56% of the fractures healed with no or minimal callus formation and 44% with moderate callus formation. In total, 13% of the anatomically reduced fractures had moderate or abundant callus formation. 22 patients opted for removal of the implants (29 LCPs), after a mean of 16 (range, 9–21) months. Conclusion. The LCP is an effective bridging device used for treating comminuted fractures, but for treating simple fractures its superiority over conventional plating is yet to be proven.
A review of lithium niobate modulators for fiber-optic communications systems

The current status of lithium-niobate external-modulator technology is reviewed with emphasis on design, fabrication, system requirements, performance, and reliability. The technology meets the performance and reliability requirements of current 2.5-, 10-, and 40-Gb/s digital communication systems, as well as CATV analog systems. The current trend in device topology is toward higher data rates and increased levels of integration. In particular, multiple high-speed modulation functions, such as 10-Gb/s return-to-zero pulse generation plus data modulation, have been achieved in a single device.
Diagnostic Value of MRI Proton Density Fat Fraction for Assessing Liver Steatosis in Chronic Viral C Hepatitis

Objective. To assess the diagnostic performance of a T1-independent, T2*-corrected multiecho magnetic resonance imaging (MRI) technique for the quantification of hepatic steatosis in a cohort of patients affected by chronic viral C hepatitis, using liver biopsy as gold standard. Methods. Eighty-one untreated patients with chronic viral C hepatitis were prospectively enrolled. All included patients underwent MRI, transient elastography, and liver biopsy within a time interval <10 days. Results. Our cohort of 77 patients included 43/77 (55.8%) males and 34/77 (44.2%) females with a mean age of 51.31 ± 11.27 (18–81) years. The median MRI PDFF showed a strong correlation with the histological fat fraction (FF) (r = 0.754, 95% CI 0.637 to 0.836, P < 0.0001), and the correlation was influenced by neither the liver stiffness nor the T2* decay. The median MRI PDFF result was significantly lower in the F4 subgroup (P < 0.05). The diagnostic accuracy of MRI PDFF evaluated by AUC-ROC analysis was 0.926 (95% CI 0.843 to 0.973) for S ≥ 1 and 0.929 (95% CI 0.847 to 0.975) for S = 2. Conclusions. Our MRI technique of PDFF estimation allowed discriminating with a good diagnostic accuracy between different grades of hepatic steatosis.
Milk fat globule E-8 and interleukin 17 in systemic lupus erythematosus: partners in crime?

Objectives Systemic lupus erythematosus (SLE) is a multi-factorial, autoimmune disease with a wide array of manifestations. The pro-inflammatory cytokine interleukin (IL)-17 has been implicated in the inflammatory response and tissue damage in SLE; however, its correlation with disease activity is still questionable. Meanwhile, efficient clearance of apoptotic cells is required for immune tolerance. An abnormally low or high level of milk fat globule (MFG-E8) can result in impaired apoptotic cell clearance and the subsequent autoimmune response. In this study, we endeavoured to compare the levels of MFG-E8 and IL-17 in SLE patients and healthy controls and to reveal the alleged association of these levels with SLE disease activity. Material and methods Serum samples from 57 SLE patients and 30 healthy control subjects were examined for quantitation of MFG-E8 and IL-17 levels using ELISA. Systemic lupus erythematosus disease activity was calculated using the SLE Disease Activity Index (SLEDAI). Clinical manifestations and laboratory findings of the patients were also recorded. Results We report that serum MFG-E8 levels were significantly elevated in the sera of SLE patients compared to healthy controls (p-value = 0.019). Likewise, IL-17 levels were higher in SLE patients (p-value < 0.001). A positive correlation was revealed between MFG-E8 level and proteinuria. Surprisingly, there was a poor correlation between disease activity and the levels of either IL-17 or MFG-E8. Conclusions Although serum MFG-E8 and IL-17 levels were higher in SLE patients than in normal controls, our results indicate that they cannot accurately reflect the disease activity. Meanwhile, further studies are needed to assess MFG-E8 and IL-17 as potential therapeutic targets in SLE patients.
Infection Strategies of Intestinal Parasite Pathogens and Host Cell Responses

Giardia lamblia, Cryptosporidium sp. , and Entamoeba histolytica are important pathogenic intestinal parasites and are amongst the leading causes worldwide of diarrheal illness in humans. Diseases caused by these organisms, giardiasis, cryptosporidiosis, and amoebiasis, respectively, are characterized by self-limited diarrhea but can evolve to long-term complications. The cellular and molecular mechanisms underlying the pathogenesis of diarrhea associated with these three pathogens are being unraveled, with knowledge of both the strategies explored by the parasites to establish infection and the methods evolved by hosts to avoid it. Special attention is being given to molecules participating in parasite–host interaction and in the mechanisms implicated in the diseases’ pathophysiologic processes. This review focuses on cell mechanisms that are modulated during infection, including gene transcription, cytoskeleton rearrangements, signal transduction pathways, and cell death.
Selenoprotein Transcript Level and Enzyme Activity as Biomarkers for Selenium Status and Selenium Requirements of Chickens (Gallus gallus)

The NRC selenium (Se) requirement for broiler chicks is 0.15 μg Se/g diet, based primarily on weight gain and feed intake studies reported in 1986. To determine Se requirements in today’s rapidly growing broiler chick, day-old male chicks were fed Se-deficient basal diets supplemented with graded levels of Se (0, 0.025, 0.05, 0.075, 0.1, 0.2, 0.3, 0.5, 0.75, and 1.0 μg Se/g) as Na2SeO3 (5/treatment). Diets contained 15X the vitamin E requirement, and there were no gross signs of Se-deficiency. At 29 d, Se-deficient chicks weighed 62% of Se-supplemented chicks; 0.025 μg Se/g reversed this effect, indicating a minimum Se requirement of 0.025 μg Se/g diet for growth for male broiler chicks. Enzyme activities in Se-deficient chicks for plasma GPX3, liver and gizzard GPX1, and liver and gizzard GPX4 decreased dramatically to 3, 2, 5, 10 and 5%, respectively, of Se-adequate levels, with minimum Se requirements of 0.10–0.13 μg Se/g, and with defined plateaus above these levels. Pancreas GPX1 and GPX4 activities, however, lacked defined plateaus, with breakpoints at 0.3 μg Se/g. qPCR measurement of all 24 chicken selenoprotein transcripts, plus SEPHS1, found that SEPP1 in liver, GPX3 in gizzard, and SEPP1, GPX3 and SELK in pancreas were expressed at levels comparable to housekeeping transcripts. Only 33%, 25% and 50% of selenoprotein transcripts were down-regulated significantly by Se deficiency in liver, gizzard and pancreas, respectively. No transcripts could be used as biomarkers for supernutritional Se status. For export selenoproteins SEPP1 and GPX3, tissue distribution, high expression and Se-regulation clearly indicate unique Se metabolism, which may underlie tissues targeted by Se deficiency. Based on enzyme activities in liver, gizzard, and plasma, the minimum Se requirement in today’s broiler chick is 0.15 μg Se/g diet; pancreas data indicate that the Se requirement should be raised to 0.2 μg Se/g diet to provide a margin of safety.
Inequality in Infant Survival Rates in India : Identi fi cation of State-Dependence

Data from a number of regions indicate that childhood deaths are unequally distributed across families. This has been identified, in previous research, with (observed and unobserved) heterogeneity between families. In this paper, we investigate whether, on top of these correlated risks, there is a causal process at work within families, whereby the death of a child elevates the risk of death of the succeeding sibling. Borrowing language from the unemployment literature, the causal process is termed state dependence or scarring. To the extent that scarring exists, a social multiplier comes into play, raising the payoff to policies that reduce infant mortality. Acknowledging scarring effects is also potentially relevant to understanding the relation of mortality and fertility behaviour within families. The analysis is conducted using data for the 15 major states of India. Large scarring effects are observed in 14 of the 15 states.
Action prediction modulates both neurophysiological and psychophysical indices of sensory attenuation

Sensory attenuation refers to the observation that stimuli that are predicted based on one’s action are attenuated. This phenomenon has primarily been observed as a neurophysiological phenomenon, with reduced Event-Related Potential (ERP) (e.g., Bäss et al., 2008) and BOLD (e.g., Blakemore et al., 1998). However, psychophysical investigations (e.g., Sato, 2008; Cardoso-Leite et al., 2010; Roussel et al., 2013) have confirmed that action prediction also influences the perception of sensory action effects. The present study recorded both neurophysiological and psychophysical measures in a single experiment, to confirm whether the two phenomena are related. In addition, by measuring the ERP modulations of both stimulus contrast and prediction congruency, we sought to directly relate the neurophysiological phenomenon to the magnitude of sensory processing in the brain. Participants performed left- and right-hand voluntary actions that were previously associated with the letters A and H. In the test phase, participants were presented with these same two letters, at one of two possible contrasts. Participants were required to report which of the two possible contrasts had been presented. We observed both reduced contrast discrimination (in line with Roussel et al., 2013) and a reduced ERP response for congruent action-effects. Furthermore, our congruency modulation was observed on the same component that differed as a function of stimulus contrast. Taken together these results strongly suggest that neurophysiological indices of sensory attenuation reflect reduced sensory processing of voluntary action effects.
The Role of Islamic Banking in Economic Growth

Islamic banking is currently one of the fastest growing segments of the financial market industry, operating in over 75 countries through 300 institutions. While past literature has established the development of financial institutions as a determinant of economic growth, research on the correlation of the diffusion of Islamic banking with economic growth is limited. This study seeks to add to the literature by empirically analyzing the economic growth determinative power of Islamic banks. Confirming past research, Muslim prevalence in a population is found to be the most significant determinant of the diffusion of Islamic banks. Using this exogenous instrument in 2SLS regressions, results show that Islamic banks are not significantly correlated with economic growth. Most notably, including the Islamic banking instrument affects the strength of beta-convergence. Basic Solovian specifications show that convergence occurs; countries with higher initial GDP per capita grow more slowly. After accounting for the intensity of Islamic banking, this effect becomes much less statistically significant, suggesting that some of the effect of convergence may operate through the propensity to adopt Islamic banking. Empirical analysis disaffirms the hypothesis that Islamic banks minimize the explanatory power of legal origin on economic growth due to their independent implementation of Shariah law; the results show that accounting for Islamic banks has no effect on the determinative power of legal origin. Finally, the correlation of Islamic banking and financial deepening is largely dependent on legal origin, resulting in negative effects for countries with British legal origin and positive for those with French legal origin.
The Cyclin-Dependent Kinase 5 Activators p35 and p39 Interact with the α-Subunit of Ca2+/Calmodulin-Dependent Protein Kinase II and α-Actinin-1 in a Calcium-Dependent Manner

Cyclin-dependent kinase 5 (Cdk5) is a critical regulator of neuronal migration in the developing CNS, and recent studies have revealed a role for Cdk5 in synaptogenesis and regulation of synaptic transmission. Deregulation of Cdk5 has been linked to the pathology of neurodegenerative diseases such as Alzheimer's disease. Activation of Cdk5 requires its association with a regulatory subunit, and two Cdk5 activators, p35 and p39, have been identified. To gain further insight into the functions of Cdk5, we identified proteins that interact with p39 in a yeast two-hybrid screen. In this study we report that α-actinin-1 and the α-subunit of Ca2+/calmodulin-dependent protein kinase II (CaMKIIα), two proteins localized at the postsynaptic density, interact with Cdk5 via their association with p35 and p39. CaMKIIα and α-actinin-1 bind to distinct regions of p35 and p39 and also can interact with each other. The association of CaMKIIα and α-actinin-1 to the Cdk5 activators, as well as to each other, is stimulated by calcium. Further, the activation of glutamate receptors increases the association of p35 and p39 with CaMKIIα, and the inhibition of CaMKII activation diminishes this effect. The glutamate-mediated increase in association of p35 and CaMKIIα is mediated in large part by NMDA receptors, suggesting that cross talk between the Cdk5 and CaMKII signal transduction pathways may be a component of the complex molecular mechanisms contributing to synaptic plasticity, memory, and learning.
A Comparative Analysis of Students’ Performance in Economics in Private and Public Secondary Schools in Lagos State, Nigeria

Abstract The study was carried out to compare the academic performance of students in the private and public secondary schools in the subject of economics in Lagos State. Samples of 120 students and 60 teachers were randomly selected from five private secondary schools and five public secondary schools in Oshodi/Isolo and Alimosho Local Government areas of Lagos State. The instrument used for the collection of data was a questionnaire. The data collected was analyzed using simple percentages, means and standard deviations. All hypotheses were subjected to a one-way analysis of variance at a 0.05 level of significance. The findings revealed that the school location, socio-economic status of teachers and the availability of instructional materials have an impact on the students’ performance in private secondary schools in Lagos State. It was concluded that the students in private schools did better than their counterparts in public schools academically.
The Study And Comparision Of The Level Of Motivation, Attributional Style, Locus Of Control, And Career Indecision Between Black

The purpose of this study was to investigate the difference between Black and White 9 grade suburban students in regard to career indecision and certainty, and to determine what relationship exists between career indecision/certainty, motivational level, locus of control, and attributional style. The sample size of this study was 95 ninth grade students from a Seminole County high school in the state of Florida. Some of the demographic variables taken into account for this study were student socioeconomic status, involvement in special programming at school (i.e. Exceptional Education, or Advanced Placement), parental education level, and parental occupation. The data in this study was collected through the use of the Career Decision Scale (CDS), Children’s Attributional Style Questionnaire-Revised (CASQ-R), Children’s Nowicki-Strickland Internal External Locus of Control Scale (CNISE), and the Five Item Polarized Motivation Scale. The results of this study came as a result of the use of an ANOVA and Mann Whitney test, as well as a series of simple linear regression analyses. The ANOVA and Mann Whitney test determined if there was a difference in career indecision/ certainty level based on race. The linear regression analysis compared the variables of career indecision/certainty, motivation level, attributional style, and locus of control to uncover any predictive relationships. Post hoc analyses were also conducted to determine if the variables of motivational level, locus of control, attributional style, and career indecision/certainty are predictors for race.