Miracle-dz/UniFAR-FTUs huggingface dataset:
Perioperative changes in serum CA125 levels: a prognostic factor for disease-specific survival in patients with ovarian cancer

Objective In patients with advanced stage epithelial ovarian cancer (EOC) the volume of residual tumor after debulking is known as prognostic factor for survival. We wanted to examine the relationship between postoperative decline in serum CA125 and residual disease after cytoreductive surgery and evaluate perioperative changes in serum CA125 levels as predictor for disease-specific survival. Methods A retrospective study was conducted of patients with FIGO stage IIb-IV EOC treated with cytoreductive surgery, followed by chemotherapy between 1996 and 2010 in three hospitals in the Southeastern region of the Netherlands. Data were analyzed with the use of multilevel linear regression and Cox-proportional hazard regression models. Results A postoperative decline in serum CA125 level of ≥80% was associated with complete primary cytoreduction (p=0.035). Univariate analyses showed favorable associations with survival for both the degree of decline in serum CA125 and residual tumor after primary cytoreduction. In multivariate analyses the decline in serum CA125 but not the outcome of surgery remained significantly associated with better survival (HR50%–79%=0.52 [95% CI: 0.28–0.96] and HR≥80%=0.26 [95% CI: 0.13–0.54] vs. the serum CA125 decline of <50% [p<0.001]). Conclusion The current study, although hampered by possible biases, suggests that the perioperative decline in serum CA125 is an early biomarker that predicts disease-specific survival in patients who underwent primary cytoreductive surgery for advanced stage EOC. If confirmed prospectively, the perioperative change in serum CA125 could be a better marker for residual tumor volume after primary cytoreductive surgery (and therewith disease-specific survival) than the surgeons’ estimation of residual tumor volume.
The Topological Properties of Virus-Human Protein Interaction Networks

In the research of biological networks, it is an important problem how to use the quantity to identify essential protein-protein interactions. In this paper, a new definition "representative value of networks", denoted as " RV ", is presented and applied to analyze the topological properties of three protein-protein interaction networks. From calculation we find that the relationship between human protein-protein interactions is highly clustered, for example, the percentage of value of the top 20% proteins of representative value from high to low accounts for 71.96%. The virus-human protein interactions (i.e. virus attacks human) are selective. And the attack of the virus also has a high aggregation. These results show that the proposed new definition is reasonable and can be considered as an important index for analyzing the topological properties of biological networks.
Acute effects of inspiratory pressure support during exercise in patients with COPD

The aim of the present study was to evaluate the acute effects of inspiratory pressure support (IPS) of 5 cmH2O (IPS5) and 10 cmH2O (IPS10) on exercise endurance. Forty-five patients with COPD (mean forced expiratory volume in one second (FEV1)=39±14% pred) performed three constant-load endurance tests on a cycle ergometer at 75% of maximal workload. One test was without IPS, one test with IPS5, and one with IPS10. No statistically significant difference was found in exercise endurance between tests without IPS and IPS5 (4.2±2.6 versus 4.4±2.9 min). In contrast, IPS10 resulted in a statistically significant increase in endurance compared with exercise without IPS (6.3±6.7 versus 4.2±2.6 min), as well as compared with exercise with IPS5 (6.3±6.7 versus 4.4±2.9 min). A wide scatter in individual responses to IPS was found, ranging from a deterioration of 1.6 min (−36%) to an improvement of 16.3 min (+445%). In only 15 patients, the increase in endurance exceeded the upper limit of the 95% confidence interval. Stepwise multiple regression analysis showed that maximal inspiratory pressure was the most important determinant of the increase in exercise endurance due to the application of IPS10. It was concluded that in contrast to inspiratory pressure support of 5 cmH2O, the application of inspiratory pressure support of 10 cmH2O during exercise resulted in a statistically significant improvement in exercise endurance in patients with COPD compared with exercise without inspiratory pressure support. However, on an individual basis, large differences in responses were found. Inspiratory muscle weakness was revealed as a determinant of improvement in exercise endurance due to the application of inspiratory pressure support of 10 cmH2O, explaining only 24% of the variance in outcome.
Quantitative Inspection of Remanence of Broken Wire Rope Based on Compressed Sensing

Most traditional strong magnetic inspection equipment has disadvantages such as big excitation devices, high weight, low detection precision, and inconvenient operation. This paper presents the design of a giant magneto-resistance (GMR) sensor array collection system. The remanence signal is collected to acquire two-dimensional magnetic flux leakage (MFL) data on the surface of wire ropes. Through the use of compressed sensing wavelet filtering (CSWF), the image expression of wire ropes MFL on the surface was obtained. Then this was taken as the input of the designed back propagation (BP) neural network to extract three kinds of MFL image geometry features and seven invariant moments of defect images. Good results were obtained. The experimental results show that nondestructive inspection through the use of remanence has higher accuracy and reliability compared with traditional inspection devices, along with smaller volume, lighter weight and higher precision.
Franchisee Use of Bootstrapping: An Exploratory Study of Financing Decisions.

According to the Census Bureau report in 2010, franchising accounts for 10.5% of businesses in the U.S. Despite the economic impact of franchising, little research examines financing decisions by franchisees in the startup phase of their businesses. We examine the use of debt financing, primarily bootstrapping, by franchisees to fund their businesses in the earliest stages of operation. The research analyzes data from the Kauffman Firm Survey (KFS), and we develop an exploratory model of franchisee activity. Consequences of the lack of loan availability will have detrimental effects on the success of franchise startups. Implications for practice, policy and future research are discussed.
Combined Conditional Random Fields and n -Gram Language Models for Gene Mention Recognition

In this paper, we propose the use of character n-gram and multiple conditional random field (CRF) models for BioCreAtIvE 2 Task 1, gene/protein name recognition. We investigated different state transition weighting schemes for CRFs and discovered that models provided independent nonoverlapping mentions. To improve recall, the results of multiple models are combined. To improve precision, character n-gram models classify gene/protein mention containing sentences. Our best approach achieved a precision of 84.35%, recall of 81.39% and F-measure of 82.85%.
A Clustering Routing Algorithm Based on Adaptive PSO in WSNs

The large-scale deployment of wireless sensor networks (WSNs) and the need for data aggregation necessitate efficient organization of the network topology for the purpose of balancing the load and prolonging the network lifetime. Clustering has proven to be an effective approach for organizing the network into a connected hierarchy. In this paper, we propose a novel clustering routing algorithm based on adaptive particle swarm optimization (APSO). As we know, PSO is a typical swarm intelligence algorithm, it's inspired by social behavior of bird flocking and acted as a fine optimization method. We utilize this advantage and improve it to gain better convergence. The performance of our protocol is compared with the well known cluster-based protocol LEACH. Simulation results demonstrate that our protocol can achieve better network lifetime over its comparative.
Predicting Sexual Intention to Engage in Premarital Sex Among Late Adolescent in Kuantan Government Secondary Schools: An Application of Theory of Planned Behaviour

The Theory of Planned Behavior (TPB) states that behaviour is determined by four main domains of social-cognitive factors; attitudes, social norms, self-efficacy and sexual intention. The aim of this study was to explore the correlation of the socio-cognitive factors predicting sexual intention to engage in premarital sex amongst late adolescent in Kuantan government secondary schools.
Overtaking frequency and advanced driver assistance systems

This paper shows results of an observation of overtaking frequencies on roads with opposing traffic. This observation is a first step of research regarding potential safety effects of advanced driver assistance systems on overtaking on two lane rural roads. We determine overtaking frequencies as a function of flow rates on both directions, distinguishing different vehicle types. Observed overtaking frequencies are lower than overtaking demand, especially when the directional split becomes more equal. Therefore we recommend adding directional split to the equation to calculate overtaking frequency.
Structure and stability of the compressible Stuart vortex

The structure and two- and three-dimensional stability properties of a linear array of compressible Stuart vortices (CSV; Stuart 1967; Meiron et al. 2000) are investigated both analytically and numerically. The CSV is a family of steady, homentropic, two-dimensional solutions to the compressible Euler equations, parameterized by the free-stream Mach number $M_{\infty}$, and the mass flux $\epsilon$ inside a single vortex core. Known solutions have $0 \,{<}\,M_{\infty}\,{<}\,1$. To investigate the normal-mode stability of the generally spatially non-uniform CSV solutions, the linear partial-differential equations describing the time evolution of small perturbations to the CSV base state are solved numerically using a normal-mode analysis in conjunction with a spectral method. The effect of increasing $M_{\infty}$ on the two main classes of instabilities found by Pierrehumbert & Widnall (1982) for the incompressible limit $M_{\infty} \,{\rightarrow}\, 0$ is studied. It is found that both two- and three-dimensional subharmonic instabilities cease to promote pairing events even at moderate $M_{\infty}$. The fundamental mode becomes dominant at higher Mach numbers, although it ceases to peak strongly at a single spanwise wavenumber. We also find, over the range of $\epsilon$ investigated, a new instability corresponding to an instability on a parallel shear layer. The significance of these instabilities to experimental observations of growth in the compressible mixing layer is discussed. In an Appendix, we study the CSV equations when $\epsilon$ is small and $M_{\infty}$ is finite using a perturbation expansion in powers of $\epsilon$. An eigenvalue determining the structure of the perturbed vorticity and density fields is obtained from a singular Sturm–Liouville problem for the stream-function perturbation at $O(\epsilon)$. The resulting small-amplitude steady CSV solutions are shown to represent a bifurcation from the neutral point in the stability of a parallel shear layer with a tanh-velocity profile in a compressible inviscid perfect gas at uniform temperature.
The host galaxy of GRB 031203 : a new spectroscopic study

Aims. The host galaxy of the long-duration gamma-ray burst (GRB) 031203 (HG 031203) offers a precious opportunity to study in detail the environment of a nearby GRB. The aim is to better characterize this galaxy and analyse the possible evolution with time of the spectroscopic quantities we derive. Methods. We analyse HG 031203 using a set of optical spectra acquired with the ESO-VLT and Keck telescope. We compare the metallicity, luminosity and star formation properties of this galaxy and of the other supernova-long gamma-ray burst hosts in the local universe (z < 0.2) against the KPNO International Spectroscopic Survey. Results. HG031203 is a metal poor, actively star forming galaxy (star formation rate of 12.9 ± 2.2 M ⊙ yr -1 ) at z = 0.1054. From the emission-line analysis we derive an intrinsic reddening E HG (B - V) ≈ 0.4. This parameter doesn't show a compelling evidence of evolution at a month time-scale. We find an interstellar medium temperature of ≈12 500 K and an electronic density of N e = 160 cm -3 . After investigating for possible Wolf-Rayet emission features in our spectra, we consider dubious the classification of HG 031203 as a Wolf-Rayet galaxy. Long gamma-ray burst (LGRB) and supernova hosts in the local universe (z < 0.2) show, on average, specific star formation rates higher than ordinary star forming galaxy at the same redshift. On the other hand, we find that half of the hosts follows the metallicity-luminosity relation found for star-burst galaxies; HG 031203 is a clear outlier, with its really low metallicity (12 + log (O/H)= 8.12 ± 0.04).
Do Schooling Laws Matter? Evidence from the Introduction of Compulsory Attendance Laws in the United States

This paper examines the effects of introducing compulsory attendance laws on the schooling of U.S. children for three overlapping time periods: 1880-1927, 1890-1927, and 1898-1927. The previous literature finds little effect of the laws, which is somewhat surprising given that the passage of these laws coincided with rising attendance. Using administrative panel data, this paper finds that laws passed after 1880 had significant effects on enrollment and attendance. Laws passed after 1890, for which both administrative and retrospective census data are available, had significant effects on enrollment, attendance, and educational outcomes. In both cases, the timing of increases in enrollment and attendance is consistent with a causal effect of the laws. For men in the 1898-1927 period who reported positive wage income in the 1940 census, compulsory attendance laws increased schooling and wage income. The OLS estimates of the return to a year of schooling are 8 percent and the IV estimates are 11 to 14 percent.
LARGE-SCALE TESTS OF DISTRIBUTED SYSTEMS WITH INTEGRATED EMULATION OF ADVANCED NETWORK BEHAVIOR

Reproducing the characteristics of complex network infrastructures is not supported by current testing environments for distributed systems. We argue that the emulation of multi-level topologies and fine-grained network behavior is necessary to provide an adequate testbed for experiments with distributed systems. Therefore, we developed an extensible emulation environment called NESSEE, which emulates application behavior as well as network aspects. Evaluation results show its applicability for large-scale tests. Furthermore, the developed NESSEE platform is actually used by our industry partner Citrix Online for testing video conferencing and eCollaboration systems
Providing public intradomain traffic matrices to the research community

This paper presents a new publicly available dataset from GÉANT, the European Research and Educational Network. This dataset consists of traffic matrices built using full IGP routing information, sampled Netflow data and BGP routing information of the GÉANT network, one per 15 minutes interval for several months. Potential benefits of publicly available traffic matrices comprise improving our understanding of real traffic matrices, their dynamics, and to make possible the benchmarking of intradomain traffic engineering methods
The significant others of subjective norm - A scientometric study of subjective norm in IS top-journals over two decades

Undoubtedly social influence in IS research is an issue that needs to be much more clearly examined. In order to assuage the wants for more research in this field we conducted a scientometric analysis of subjective norm in the IS top-journals of the JAIS ranking for the last two decades. In total 113 empirical and conceptual research models predominately in adoption research contained the factor subjective norm. The results revealed that subjective norm is just in seven of ten models a significant antecedent. To gain more knowledge about this problem we followed the ideas of social psychology and marketing researchers and correlated the strength of the impact of subjective norm with its measurement as well as the impact of intention with the impact on other endogenous variables. The results show a significant negative correlation between the significant antecedent subjective norm and its original measurement, the perceived opinion of important others. Furthermore it revealed a significant negative correlation between the significant impact of subjective norm on intention and the significant impact on other endogenous variables.
Somatostatin receptors and disease : role of receptor subtypes

The small cyclic peptide somatostatin (SST) is present in the human body in two molecular forms, SS14 and SS28, consisting of 14 and 28 amino acids, respectively (Brazean et al, 1973; Pradayrol et al, 1980). SST has widespread biological actions in different organ systems. Hypothalamic SST inhibits pituitary growth hormone and thyroid-stimulating hormone (TSH) release (as a neurohormone) and in the brain SST acts as a neurotransmitter having both stimulatory and inhibitory actions (Renaud et ai, 1975; Dodd and Kelly, 1978). Next to these actions, locally produced SST may play a regulatory role in an autocrine and/or paracrine fashion in the endocrine and exocrine pancreas and in the gastrointestinal tract (Guillemin and Gerich, 1976). SST is also synthesized by lymphoid cells and may have an immunomodulatory role in these cell types (van Hagen et al, 1994). Along with this variety of actions of SST, somatostatin receptors (SSTR) have been detected in most of the target organs of the peptide. By autoradiographic and membrane-homogenate binding studies, SSTR have been found in the central nervous system, the anterior pituitary gland, the endocrine and exocrine pancreas, the gastrointestinal tract and in (activated) immune cells in lymphoid tissues (Lamberts et al, 1991; van Hagen et al, 1994). The presence of SSTR in this variety of organ systems suggested that SST could have a role in the treatment of disease due to hyperfunction of these systems. However, several disadvantages of the native peptide hampered its practical use (Guillemin, 1978; Lamberts, 1988). Due to its very short half-life in the circulation (less than 3 minutes) the peptide has a short duration of action and must therefore be infused intravenously. Moreover, the post-infusion rebound hypersecretion of hormones by normal tissues is a major disadvantage (Besser et al, 1974a,b). The search for analogues of SST not having these disadvantages has led to the development of a class of octapeptide SST-analogues with a prolonged biological half-life. Octreotide is currently the most widely used SST-analogue. It has a halflife in the circulation of approximately 2 hours, can be given subcutaneously and in monkeys is 45 times more potent in inhibiting GH release, 11 times more potent in inhibiting glucagon release and only 1.3 times
Social Contagion and Cascade Behaviors on Twitter

It has been found in a variety of face-to-face networks that diffusion of information, behaviors and sentiments extend up to two to four degrees of distance from the original source. This regularity has been popularized as the three degrees of influence phenomenon. Prior works have suggested a number of possible explanations to this pattern. In this paper, we study it in the context of an online network. We find similar results in this online setting to those already found offline. However, our approach suggests that two of the previously proposed explanations (increasing instability of connections at greater distances from the source and simple information decay) should not be central to explain the pattern.
An Integrated Model for Customer Online Repurchase Intention

The explosion of e-commerce activities required industry and academia to understand the key determinants of consumers' online repurchase intention. We developed an integrated model by examining how utilitarian factors (perceived ease of use and perceived usefulness), the hedonic factor (perceived enjoyment), and social/psychological factors (confirmation, satisfaction and trust) directly or indirectly influenced consumers' continuance intention in the context of online shopping. Results from confirmatory factor analysis and structural equation model analysis with LISREL 8.72 indicate that both utilitarian factors and hedonic factors examined through this model provide statistically significant explanations of the variation in consumers' online repurchase intention. In the post-purchase stage, utilitarian factors play a more important role than hedonic factors in predicting customer online repurchase intention. The integrated theoretical framework explains 63% of the variations in online repurchase intention.
Deuterium toward Two Milky Way Disk Stars: Probing Extended Sight Lines with the Far Ultraviolet Spectroscopic Explorer

We have carried out an investigation of the abundance of deuterium along two extended sight lines through the interstellar medium (ISM) of the Galactic disk. The data include Far Ultraviolet Spectroscopic Explorer (FUSE) observations of HD 195965 (B1 Ib) and HD 191877 (B0 V), as well as Space Telescope Imaging Spectrograph (STIS) observations of HD 195965. The distances to HD 195965 and HD 191877, derived from spectroscopic parallax, are 794 ± 200 and 2200 ± 550 pc, respectively, making these the longest Galactic disk sight lines in which deuterium has been investigated with FUSE. The FUSE spectra contain all of the H I Lyman series transitions (and the corresponding D transitions) except Lyα. The higher Lyman lines clearly show the presence of deuterium. We use a combination of curve-of-growth analyses and line profile fitting to determine the D I abundance toward each object. We also present column densities for O I and N I toward both stars, as well as H I measured from Lyα absorption in the STIS spectrum of HD 195965. Toward HD 195965 we find D/H = (0.85) × 10-5 (2 σ), O/H = (6.61) × 10-4, and N/H = (7.94) × 10-5. Toward HD 191877 we find D/H = (0.78) × 10-5 (2 σ) and N/H = (6.76) × 10-5. The O I column density toward HD 191877 is very uncertain. Our preferred value gives O/H = (3.09) × 10-4, but we cannot rule out O/H values as low as O/H = 1.86 × 10-4, so the O/H value for this sight line should be taken with caution. The D/H ratios along these sight lines are lower than the average value of (1.52 ± 0.15) × 10-5 (2 σ in the mean) found with FUSE for the local interstellar medium (~37-179 pc from the Sun). These observations lend support to earlier detections of variation in D/H over distances greater than a few hundred parsecs. The O/H ratio toward HD 195965 is supersolar. This star is part of an OB association, so there may be local enrichment by nearby massive stars. The D/H and O/H values measured along these sight lines support the expectation that the ISM is not well mixed on distances of ~1000 pc. These observations demonstrate that although D/H studies through Lyman absorption may become impractical at d > 2500 pc and log N(H ) > 21, D/H studies in the distance range from 500 to 2500 pc may be very useful for investigating mixing and chemical evolution in the ISM.