Miracle-dz/UniFAR-FTUs huggingface dataset:
Involving the Community Elderly in the Planning and Provision of Health Services: Predictors of Volunteerism and Leadership*

ABSTRACT A rapidly growing older population has led to changes in health care, including a community health movement with an emphasis on community collaboration, self-help, and capacity building. This study examined factors in the lives of older individuals that influenced their ability and willingness to participate in a health-related community-capacity-building project to help their frailer, older neighbours. Using cross-sectional survey methodology, 107 volunteers who lived in a high density seniors' apartment complex known for its high health service utilization were compared with a random sample of 74 non-volunteers from the same community. Factors associated with volunteer involvement included age, activity level, functional ability, life satisfaction and certain personality characteristics. The study suggests that, within a community, the “younger-old” may be able to support their frailer, older neighbours so that they can remain living in the community. RÉSUMÉ La croissance rapide de la population âgée a engendré des changements en matière de soins de santé, y compris l'apparition d'un mouvement de santé communautaire qui met l'accent sur la collaboration, l'auto-assistance et le renforcement des capacités au sein de la collectivité. Cette recherche étudie les facteurs, dans la vie de personnes âgées, qui ont influencé leur aptitude et leur volonté de participer à un projet communautaire de renforcement des capacités en matière de santé, dans le but d'aider leurs voisins plus âgés à la santé fragile. Au moyen d'une étude transversale, nous avons comparé les résultats de 107 volontaires qui vivaient dans un complexe résidentiel à densité élevée pour personnes âgées réputé pour son niveau élevé d'utilisation des services de santé à ceux d'un échantillon aléatoire de 74 personnes non volontaires de la même collectivité. Parmi les facteurs liés à la participation volontaire, on compte l'âge, le niveau d'activité, l'aptitude à fonctionner, la satisfaction à l'égard de la vie ainsi que certaines caractéristiques relatives à la personnalité. Cette étude semble révéler que, au sein d'une collectivité, les personnes âgées les plus jeunes peuvent être en mesure de soutenir leurs voisins plus âgés à la santé fragile afin de leur permettre de continuer à vivre au sein de la collectivité.
Population-Based Incidence of Typhoid Fever in an Urban Informal Settlement and a Rural Area in Kenya: Implications for Typhoid Vaccine Use in Africa

Background High rates of typhoid fever in children in urban settings in Asia have led to focus on childhood immunization in Asian cities, but not in Africa, where data, mostly from rural areas, have shown low disease incidence. We set out to compare incidence of typhoid fever in a densely populated urban slum and a rural community in Kenya, hypothesizing higher rates in the urban area, given crowding and suboptimal access to safe water, sanitation and hygiene. Methods During 2007-9, we conducted population-based surveillance in Kibera, an urban informal settlement in Nairobi, and in Lwak, a rural area in western Kenya. Participants had free access to study clinics; field workers visited their homes biweekly to collect information about acute illnesses. In clinic, blood cultures were processed from patients with fever or pneumonia. Crude and adjusted incidence rates were calculated. Results In the urban site, the overall crude incidence of Salmonella enterica serovar Typhi (S. Typhi) bacteremia was 247 cases per 100,000 person-years of observation (pyo) with highest rates in children 5–9 years old (596 per 100,000 pyo) and 2–4 years old (521 per 100,000 pyo). Crude overall incidence in Lwak was 29 cases per 100,000 pyo with low rates in children 2–4 and 5–9 years old (28 and 18 cases per 100,000 pyo, respectively). Adjusted incidence rates were highest in 2–4 year old urban children (2,243 per 100,000 pyo) which were >15-fold higher than rates in the rural site for the same age group. Nearly 75% of S. Typhi isolates were multi-drug resistant. Conclusions This systematic urban slum and rural comparison showed dramatically higher typhoid incidence among urban children <10 years old with rates similar to those from Asian urban slums. The findings have potential policy implications for use of typhoid vaccines in increasingly urban Africa.
Volatile-Mediated Attraction of Greenhouse Whitefly Trialeurodes vaporariorum to Tomato and Eggplant

The behavior of the greenhouse whitefly, Trialeurodes vaporariorum Westwood (Hemiptera: Aleyrodidae), is known to be affected by plant volatile cues, but its attraction or repellent to specific volatile cues has not been deeply studied yet. Therefore, the aim of our study was to identify the most attractive plant among cultivars of tomato (Solanum lycopersicum) and eggplant (Solanum melongena) to evaluate the volatiles of plants to identify the chemical compound(s) that attract T. vaporariorum. We speculated that whitefly–host plant interaction primarily depends on plant volatile emissions and that once the plant is damaged, it might attract more whiteflies. Three intact (uninfested) tomato, four intact eggplant cultivars and whitefly infested plants of the most whitefly attractive tomato and eggplant cultivars were examined by behavioral assay experiments for attractiveness to T. vaporariorum and headspace volatile were determined by solid-phase microextraction (SPME) and gas chromatography-mass spectrometry. Whiteflies had the highest preference for the intact eggplant Kuai Yuan Qie (KYQ) among the eggplant and the tomato plant cultivars in bioassay experiments. Although both male and female whiteflies were significantly more attracted to infested KYQ plants than to intact plants, whitefly females did not select conspecific-infested YG plants. The volatile emissions among different plant cultivars in individual species and infested versus intact plants were significantly different. Among these volatiles, identified major green leaf volatiles [(Z)-3-hexen-1-ol] and terpenoids [α-pinene, (E)-β-caryophyllene, α-humulene, azulene] showed a constitutive relationship with the most whitefly preference plants. Our findings provide new insights into the chemical compounds that attract or repel whiteflies.
MEG evidence that the LIFG effect of object extraction requires similarity-based interference

This study addresses a much-debated effect on a much-debated region: the increase of left inferior frontal gyrus (LIFG) activation associated with object-extracted relative clauses. This haemodynamic result is one of the most central and most cited findings in the cognitive neuroscience of syntax and it has robustly contributed to the popular association of Broca's region with syntax. Our study had two goals: (1) to characterise the timing of this classic effect with magnetoencephalography (MEG) and (2) to connect it to psycholinguistic research on the effects of similarity-based interference during sentence processing. Specifically, behavioural studies have shown that object relatives are primarily only costly when the two preverbal noun phrases are parallel in their surface syntax, for example, both consisting of a definite determiner and a noun (e.g. the reporter who the senator attacked), as opposed to employing, for example, a definite noun phrase and a proper name (the reporter who Bill attacked). This finding suggests that the difficulty of object extraction lies not within its syntax but rather in similarity-based interference affecting working memory processes. Although working memory is a prominent hypothesis for the LIFG engagement in object extraction, the haemodynamic literature has routinely employed stimuli involving parallel as opposed to non-parallel syntax. Using written sentences presented word-by-word, we tested whether an LIFG effect of object extraction is obtained with MEG, allowing us to characterise its timing, and whether it reduces or disappears if the two preverbal noun phrases are non-parallel in their surface syntax. Our results show an LIFG increase for object relatives at around 600 ms after verb onset, but only when the preverbal arguments are parallel. These findings are consistent with memory and competition-based explanations of the LIFG effect of object extraction and challenge accounts attributing it to displacement.
Irbesartan in patients with atrial fibrillation.

BACKGROUND The risk of cardiovascular events among patients with atrial fibrillation is high. We evaluated whether irbesartan, an angiotensin-receptor blocker, would reduce this risk. METHODS We randomly assigned patients with a history of risk factors for stroke and a systolic blood pressure of at least 110 mm Hg to receive either irbesartan at a target dose of 300 mg once daily or double-blind placebo. These patients were already enrolled in one of two trials (of clopidogrel plus aspirin versus aspirin alone or versus oral anticoagulants). The first coprimary outcome was stroke, myocardial infarction, or death from vascular causes; the second was this composite outcome plus hospitalization for heart failure. RESULTS A total of 9016 patients were enrolled and followed for a mean of 4.1 years. The mean reduction in systolic blood pressure was 2.9 mm Hg greater in the irbesartan group than in the placebo group, and the mean reduction in diastolic blood pressure was 1.9 mm Hg greater. The first coprimary outcome occurred at a rate of 5.4% per 100 person-years in both groups (hazard ratio with irbesartan, 0.99; 95% confidence interval [CI], 0.91 to 1.08; P=0.85). The second coprimary outcome occurred at a rate of 7.3% per 100 person-years among patients receiving irbesartan and 7.7% per 100 person-years among patients receiving placebo (hazard ratio, 0.94; 95% CI, 0.87 to 1.02; P=0.12). The rates of first hospitalization for heart failure (a prespecified secondary outcome) were 2.7% per 100 person-years among patients receiving irbesartan and 3.2% per 100 person-years among patients receiving placebo (hazard ratio, 0.86; 95% CI, 0.76 to 0.98). Among patients who were in sinus rhythm at baseline, there was no benefit of irbesartan in preventing hospitalization for atrial fibrillation or atrial fibrillation recorded on 12-lead electrocardiography, nor was there a benefit in a subgroup that underwent transtelephonic monitoring. More patients in the irbesartan group than in the placebo group had symptomatic hypotension (127 vs. 64) and renal dysfunction (43 vs. 24). CONCLUSIONS Irbesartan did not reduce cardiovascular events in patients with atrial fibrillation. (Funded by Bristol-Myers Squibb and Sanofi-Aventis; ClinicalTrials.gov number, NCT00249795.).
Diophantine approximation by cubes of primes and an almost prime. II

Let λ1, . , λs be non-zero with λ1/λ2 irrational and let S be the set of values attained by the form λ1x 3 1 + · · ·+ λsxs when x1 has at most 6 prime divisors and the remaining variables are prime. In the case s = 4, we establish that most real numbers are “close” to an element of S. We then prove that if s = 8, S is dense on the real line.
The cortisol level and its relationship with depression, stress and anxiety indices in chronic methamphetamine-dependent patients and normal individuals undergoing inguinal hernia surgery

Background: Stimulants addition and abuse can cause some functional and morphological changes in the normal function of glands and hormones. Methamphetamine as an addictive stimulant drug affects the Hypothalamic- pituitary-adrenal (HPA) axis and consequently makes some changes in the psychological state of the drug users. The present study aims to examine the relationship between plasma levels of cortisol with depression, stress and anxiety symptoms in chronic methamphetamine-dependent patients and normal individuals who have undergone the inguinal hernia surgery. Methods: To meet the purpose of the study, 35 chronic methamphetamine-dependent patients in the active phase of drug abuse and 35 non-users (N=70) who were homogenized regarding the demographic features were purposefully selected from among the patients referred to undergo inguinal hernia surgery since March 15 to June 9, 2015. The participants were then divided into the control and experiment group. The changes in cortisol levels in plasma were measured using Radioimmunoassay (RIA) in three-time series including 0 (upon the induction of anesthesia), 12 and 24 hours after the surgery. Further, three behavioral indices of depression, anxiety and stress were measured using the Depression Anxiety Stress Scale 21 (DASS-21) and then the data were analyzed using t-test and Pearson Correlation coefficient. Results: The plasma level of cortisol in the chronic methamphetamine-dependent patients (experiment group) had a significant increase in 24 hours after surgery (p<0.05). This study showed that cortisol levels in chronic methamphetamine-dependent patients were significantly higher than non-dependent patients in response to alarming events such as inguinal surgery. Changes in cortisol levels were intensified due to a confrontation with the phenomenon of pain and anxiety. In addition, depression index was higher in the chronic methamphetaminedependent patients than that in the non-dependent patients. However, there was no significant relationship between the cortisol level and depression index (p=0.001). Conclusion: The Hypothalamic-pituitary-adrenal (HPA) axis is considered as a key structure in the addiction to simulants, the reason which can explain the faster response of the chronic methamphetamine-dependent patients to the stressors such as surgery.
Effects of Repetitive Transcranial Magnetic Stimulation in Aphasic Stroke: A Randomized Controlled Pilot Study

Background and Purpose— Although functional imaging studies suggest that recruitment of contralesional areas hinders optimal functional reorganization in patients with aphasic stroke, only limited evidence is available on the efficacy of noninvasive brain stimulation such as repetitive transcranial magnetic stimulation aimed at suppression of contralateral overactivation. Methods— In this randomized, controlled, blinded pilot study, the effect of 1-Hz repetitive transcranial magnetic stimulation over right-hemispheric Broca homolog in subjects with poststroke aphasia in the subacute stage was examined. According to their group allocation, patients received, in addition to conventional speech and language therapy, multiple sessions of repetitive transcranial magnetic stimulation either over the right-hemispheric inferior frontal gyrus (intervention group) or over the vertex (control group). The primary outcome parameter was the change in laterality indices as quantified by activation positron emission tomography before and after the 2-week intervention period. The clinical efficacy was evaluated with the Aachen Aphasia Test. Results— At baseline, no group differences were discovered for age, laterality indices, or mean Aachen Aphasia Test scores. Four patients were lost to follow-up, but none due to side effects of the transcranial magnetic stimulation. Positron emission tomography revealed an activation shift toward the right hemisphere in the control group (P=0.0165), which was absent in the intervention group. Furthermore, the latter improved significantly clinically by a mean of 19.8 points in the Aachen Aphasia Test total score (P=0.002), whereas the control group did not. There was however no clear linear relationship between the extent of laterality shift and clinical improvement (r=0.193, P=nonsignificant). Conclusions— Repetitive transcranial magnetic stimulation might be an effective, safe, and feasible complementary therapy for poststroke aphasia.
The Influence of Motion Paths and Assembly Sequences on the Stability of Assemblies

In this paper, we present an approach for the stability analysis of mechanical part disassembly considering part motion in the presence of physical forces such as gravity and friction. Our approach uses linear complementarity to analyze stability as parts are moved out of the assembly. As each part is removed from the assembly along a specified path during disassembly, we compute the contact forces between parts in the remaining assembly; positive contact forces throughout the disassembly process imply the disassembly sequence is stable (since the parts remain in contact with one another). However, if the part that is being taken out induces motion of other parts in the remaining subassembly, we conclude the disassembly sequence is unstable. Thus, we are able to simulate the entire disassembly considering physical forces and part motion, which has not previously been done. We then show the influence of part motion on stable disassembly. In contrast to prior work on disassembly that has focused either on planning part motions based on only geometric constraints, or on analyzing the stability of an assembly without considering part motions, we explore the relation between part motion and the selection of stable disassembly sequences in 2-D and 3-D. We establish conditions that characterize path-dependent assemblies, where motion paths can play a significant role in stable disassembly. Since we track the motion of all parts in an assembly, instability inducing motions can be identified and prevented by introducing appropriate fixtures by selecting alternative disassembly sequences or by changing the motion paths. We extend the stability analysis for single part disassembly to stability analysis of subassembly disassembly. We additionally show that in the presence of friction, assembly and disassembly can be noninvertible
Silica Nanoparticles Effects on Blood Coagulation Proteins and Platelets

Interaction of nanoparticles with the blood coagulation is important prior to their using as the drug carriers or therapeutic agents. The aim of present work was studying of the primary effects of silica nanoparticles (SiNPs) on haemostasis in vitro. We studied the effect of SiNPs on blood coagulation directly estimating the activation of prothrombin and factor X and to verify any possible effect of SiNPs on human platelets. It was shown that SiNPs shortened coagulation time in APTT and PT tests and increased the activation of factor X induced by RVV possibly due to the sorption of intrinsic pathway factors on their surface. SiNPs inhibited the aggregation of platelet rich plasma induced by ADP but in the same time partially activated platelets as it was shown using flow cytometry. The possibility of SiNPs usage in nanomedicine is strongly dependant on their final concentration in bloodstream and the size of the particles that are used. However SiNPs are extremely promising as the haemostatic agents for preventing the blood loss after damage.
Remineralization Capacity of Three Fissure Sealants with and without Gaseous Ozone on Non-Cavitated Incipient Pit and Fissure Caries.

OBJECTIVE The purpose of this study was to investigate the remineralization activation of the application of three fissure sealants (FSs), alone or with gaseous ozone (GO), on non-cavitated initial caries and evaluate the clinical success of FS. STUDY DESIGN Sixty children who had DIAGNOdent scores between 10-30 on bilateral symmetric mandibular first permanent molars were included in study. In a split-mouth design, teeth were assigned to experimental (with GO) and control (without GO) groups. GO was applied to teeth on one side and then the same brand of randomly selected FSs was applied to the teeth on both sides. Children were divided into 3 groups based on type of FS (Group 1: Aegis {Bosworth Co, North Hamlin Avenue Skokie, Illinois, USA}, Group 2: Fuji Triage {GC, Tokyo, Japan}, Group 3: Helioseal {Ivoclar Vivadent, Liechtenstein, Germany}). All FSs were then examined for retention rates at 1, 3, 6, 9, and 12 months; at the end of 12 months, all FSs were removed with an air-abrasion device and DIAGNOdent scores noted to compare with the initial values. RESULTS The application of GO with either Fuji Triage or Aegis FS was effective on remineralization (p<0.05); however, the application of Helioseal FSs was not effective (p>0.05). The 1(st) and 12(th) months' full retention rates of Fuji Triage FSs was a significant difference (p<0.05) from other FSs (Aegis and Helioseal) (p>0.05). CONCLUSIONS GO+Aegis FS showed the highest remineralization; and, at the end of 12 months, its clinical success was higher than other FSs.
Nitrogen and Water Interactions in Subsurface Drip‐Irrigated Cauliflower II. Agronomic, Economic, and Environmental Outcomes

Water x N rate experiments were conducted on subsurface drip-irrigated cauliflower (Brassica olearacea L. var. botrytis L.) during three winter growing seasons in southern Arizona. A range of water and N rates were selected to permit the calculation of appropriate water × N production functions. The objectives were to (i) determine the effects and interactions of irrigation water and N inputs on crop N uptake, residual soil NO 3 -N, N-use efficiency, and unaccounted fertilizer N, and (ii) evaluate agronomic, economic, and environmental production criteria during three growing seasons. Spatial analysis was used to identify overlap of acceptable zones of marketable yield, net return, and unaccounted fertilizer N within each growing season. Acceptable yields and net return were defined as ≥95% of the maximum predicted response within the range of the treatments; acceptable unaccounted fertilizer N was defined as ≤ 40 kg ha -1 . Net returns and aboveground plant biomass N were significantly affected (P < 0.01) by N rate and in 2 yr by irrigation. There were also significant irrigation treatment x N rate interactions for net returns and biomass N. Residual soil NO 3 -N concentrations increased with N rate and decreased with soil water tension (SWT). Average amounts of residual soil NO 3 -N (0-0.9 m) for the highest N rate during the three seasons were 317, 296, and 180 kg ha -1 for the low, medium, and high irrigation treatments, respectively. Unaccounted fertilizer N was significantly affected (P < 0.05) by irrigation treatment, N rate, and irrigation treatment x N rate interactions each year. Overlap of acceptable zones of marketable yields, net returns, and unaccounted N was achieved in one of the three years. The single combination of SWT and N rate that came closest to producing optimal or near-optimal agronomic, economic, and environmental outcomes in all three years was 10 to 12 kPa and 350 to 400 kg N ha -1 .