Miracle-dz/UniFAR-FTUs huggingface dataset:
The effect of long-term housing in an aviary and battery cages on the physical condition of laying hens: body weight, feather condition, claw length, foot lesions, and tibia strength.

The physical condition of laying hens housed for 3 yr in either traditional battery cages or an aviary was compared. Aviary hens were significantly lighter than those in cages (2,021 vs 2,241 g; P = .0001), despite having consumed slightly more feed (121 vs 116 g per bird per d, P = .16). Caged hens had poorer feather cover (P = .0001); 39% of caged birds had denuded areas greater than 5 cm2, whereas 68% of aviary hens had complete plumage. The length of both center front and rear claws was significantly greater in caged hens (36.3 vs 30.3 mm, P = .001 and 19.2 vs 16.1 mm, P = .012, respectively). The total number of foot lesions did not differ with housing system; however, caged hens had significantly more toe injuries (P < .001), and aviary birds had more injuries on the soles of their feet (P = .005). All aviary birds with foot lesions had only a single lesion, whereas one-sixth of caged hens with lesions had more than one. No difference in tibial breaking strength was found due to housing system. Overall, the results suggest that aviary systems can offer some distinct advantages over traditional battery cages with regard to the physical condition of laying hens, given a high level of management.
A Framework of Rapid Regional Tsunami Damage Recognition From Post-event TerraSAR-X Imagery Using Deep Neural Networks

Near real-time building damage mapping is an indispensable prerequisite for governments to make decisions for disaster relief. With high-resolution synthetic aperture radar (SAR) systems, such as TerraSAR-X, the provision of such products in a fast and effective way becomes possible. In this letter, a deep learning-based framework for rapid regional tsunami damage recognition using post-event SAR imagery is proposed. To perform such a rapid damage mapping, a series of tile-based image split analysis is employed to generate the data set. Next, a selection algorithm with the SqueezeNet network is developed to swiftly distinguish between built-up (BU) and nonbuilt-up regions. Finally, a recognition algorithm with a modified wide residual network is developed to classify the BU regions into wash away, collapsed, and slightly damaged regions. Experiments performed on the TerraSAR-X data from the 2011 Tohoku earthquake and tsunami in Japan show a BU region extraction accuracy of 80.4% and a damage-level recognition accuracy of 74.8%, respectively. Our framework takes around 2 h to train on a new region, and only several minutes for prediction.
The robustness of seismic moment and magnitudes estimated using spectral analysis

We present an assessment of how microseismic moment magnitude, MW , estimates vary with the method and parameters used to calculate seismic moment. This is an important topic for operators and regulators who require good magnitude estimates when monitoring induced seismicity. It is therefore imperative that these parties know and understand what errors exist in given magnitude values, something that is poorly reported. This study concentrates on spectral analysis techniques and compares MW computed in the time and frequency domains. Using recordings of MW>−1.5 events at Cotton Valley, east Texas, the maximum discrepancy between MW estimated using the different methods is 0.6 units, a significant variation. By adjusting parameters in the MW calculation we find that the radiation pattern correction term can have the most significant effect on MW , generally up to 0.8 units. Following this investigation we make a series of recommendations for estimating microseismic MW using spectral methods. Noise should be estimated and removed from recordings and an attenuation correction should be applied. The spectral level can be measured by spectral fitting or taken from the low frequency level. Significant factors in obtaining reliable microseismic MW estimates include using at least four receivers recording at ⩾1000 Hz and making radiation pattern corrections based on focal mechanism solutions, not average values.
Interplay of multiple goods, ecosystem services, and property rights in large social-ecological marine protected areas

Protected areas are a cornerstone of biodiversity conservation, and increasingly, conservation science is integrating ecological and social considerations in park management. Indeed, both social and ecological factors need to be considered to understand processes that lead to changes in environmental conditions. Here, we use a social-ecological systems lens to examine changes in governance through time in an extensive regional protected area network, the Great Barrier Reef Marine Park. We studied the peer-reviewed and nonpeer-reviewed literature to develop an understanding of governance of the Great Barrier Reef Marine Park and its management changes through time. In particular, we examined how interacting and changing property rights, as designated by the evolving marine protected area network and other institutional changes (e.g., fisheries management), defined multiple goods and ecosystem services and altered who could benefit from them. The rezoning of the Great Barrier Reef Marine Park in 2004 substantially altered the types and distribution of property rights and associated benefits from ecosystem goods and services. Initially, common-pool resources were enjoyed as common and private benefits at the expense of public goods (overexploited fisheries and reduced biodiversity and ecosystem health). The rezoning redefined the available goods and benefits and who could benefit, prioritizing public goods and benefits (i.e., biodiversity conservation), and inducing private costs (through reduced fishing). We also found that the original conceptualization of the step-wise progression of property rights from user to owner oversimplifies property rights based on its division into operational and collective-choice rule-making levels. Instead, we suggest that a diversity of available management tools implemented simultaneously can result in interactions that are seldom fully captured by the original conceptualization of the bundling of property rights. Understanding the complexities associated with overlapping property rights and multiple goods and ecosystem services, particularly within large-scale systems, can help elucidate the source and nature of some of the governance challenges that large protected areas are facing.
Alleviating catastrophic forgetting using context-dependent gating and synaptic stabilization

Significance Artificial neural networks can suffer from catastrophic forgetting, in which learning a new task causes the network to forget how to perform previous tasks. While previous studies have proposed various methods that can alleviate forgetting over small numbers (⩽10) of tasks, it is uncertain whether they can prevent forgetting across larger numbers of tasks. In this study, we propose a neuroscience-inspired scheme, called “context-dependent gating,” in which mostly nonoverlapping sets of units are active for any one task. Importantly, context-dependent gating has a straightforward implementation, requires little extra computational overhead, and when combined with previous methods to stabilize connection weights, can allow networks to maintain high performance across large numbers of sequentially presented tasks. Humans and most animals can learn new tasks without forgetting old ones. However, training artificial neural networks (ANNs) on new tasks typically causes them to forget previously learned tasks. This phenomenon is the result of “catastrophic forgetting,” in which training an ANN disrupts connection weights that were important for solving previous tasks, degrading task performance. Several recent studies have proposed methods to stabilize connection weights of ANNs that are deemed most important for solving a task, which helps alleviate catastrophic forgetting. Here, drawing inspiration from algorithms that are believed to be implemented in vivo, we propose a complementary method: adding a context-dependent gating signal, such that only sparse, mostly nonoverlapping patterns of units are active for any one task. This method is easy to implement, requires little computational overhead, and allows ANNs to maintain high performance across large numbers of sequentially presented tasks, particularly when combined with weight stabilization. We show that this method works for both feedforward and recurrent network architectures, trained using either supervised or reinforcement-based learning. This suggests that using multiple, complementary methods, akin to what is believed to occur in the brain, can be a highly effective strategy to support continual learning.
General self‐efficacy in various domains of human functioning: Evidence from five countries

Based on social-cognitive theory (Bandura, 1997), this paper examined whether perceived self-efficacy is a universal psychological construct that accounts for variance within various domains of human functioning. Perceived self-efficacy is not only of a task-specific nature, but it can also be identified at a more general level of functioning. General self-efficacy (GSE) is the belief in one’s competence to tackle novel tasks and to cope with adversity in a broad range of stressful or challenging encounters, as opposed to specific self-efficacy, which is constrained to a particular task at hand. The study aimed at exploring the relations between GSE and a variety of other psychological constructs across several countries. Relations between general self-efficacy and personality, well-being, stress appraisals, social relations, and achievements were examined among 8796 participants from Costa Rica, Germany, Poland, Turkey, and the USA. Across countries, the findings provide evidence for associations between perceived general self-efficacy and the selected variables. The highest positive associations were with optimism, self-regulation, and self-esteem, whereas the highest negative associations emerged with depression and anxiety. Academic performance is also associated with self-efficacy as hypothesized. The replication across languages or cultures adds significance to these findings. The relations between self-efficacy and other personality measures remained stable across cultures and samples. Thus, perceived general self-efficacy appears to be a universal construct that yields meaningful relations with other psychological constructs.
Therapeutic Administration of a Monoclonal Anti-Il-1β Antibody Protects Against Experimental Melioidosis

Background: Melioidosis, caused by the gram-negative bacterium Burkholderia pseudomallei, is a common cause of community-acquired sepsis in Southeast Asia and Northern Australia. The NLRP3 inflammasome and its downstream product interleukin-1 beta (IL-1&bgr;) have been proposed to play crucial roles in melioidosis. In this study, we characterized the role of IL-1&bgr; more closely and we assessed its therapeutic potential. Methods: mRNA expression of inflammasome components was determined in isolated leukocytes of 32 healthy controls and 34 patients with sepsis caused by B pseudomallei. Wild-type (WT), NLRP3-deficient (Nlrp3−/−), and Asc−/− mice were infected with B pseudomallei. In additional experiments, infected WT mice were treated with an anti-IL-1&bgr; antibody. After 24, 48, and 72 hours (h) mice were sacrificed and organs were harvested. Furthermore, survival studies were performed. Results: Patients with melioidosis exhibited lower mRNA levels of caspase-1, NLRP3, and ASC. Bacterial dissemination and organ damage were increased in B pseudomallei-infected Nlrp3−/− and Asc−/− mice, together with a reduced pulmonary cell influx. Anti-IL-1&bgr; treatment of B pseudomallei challenged mice resulted in strongly reduced bacterial counts, organ damage, and pulmonary granulocyte influx together with reduced mortality. Postponement of anti-IL-1&bgr; treatment for 24 h postinfection still protected mice during melioidosis. Conclusion: Expression of caspase-1, NLRP3, and ASC is altered in melioidosis patients. In mice, both NLRP3 and ASC contribute to the host defense against melioidosis. Anti-IL-1&bgr; treatment protects mice against B pseudomallei infection and might be a novel treatment strategy in melioidosis.
Lifestyle genomics and the metabolic syndrome: A review of genetic variants that influence response to diet and exercise interventions

ABSTRACT Metabolic syndrome (MetS) comprises a cluster of risk factors that includes central obesity, dyslipidemia, impaired glucose homeostasis and hypertension. Individuals with MetS have elevated risk of type 2 diabetes and cardiovascular disease; thus placing significant burdens on social and healthcare systems. Lifestyle interventions (comprised of diet, exercise or a combination of both) are routinely recommended as the first line of treatment for MetS. Only a proportion of people respond, and it has been assumed that psychological and social aspects primarily account for these differences. However, the etiology of MetS is multifactorial and stems, in part, on a person's genetic make-up. Numerous single nucleotide polymorphisms (SNPs) are associated with the various components of MetS, and several of these SNPs have been shown to modify a person's response to lifestyle interventions. Consequently, genetic variants can influence the extent to which a person responds to changes in diet and/or exercise. The goal of this review is to highlight SNPs reported to influence the magnitude of change in body weight, dyslipidemia, glucose homeostasis and blood pressure during lifestyle interventions aimed at improving MetS components. Knowledge regarding these genetic variants and their ability to modulate a person's response will provide additional context for improving the effectiveness of personalized lifestyle interventions that aim to reduce the risks associated with MetS.
PET imaging of cannabinoid type 2 receptors with [11C]A-836339 did not evidence changes following neuroinflammation in rats

Cannabinoid type 2 receptors (CB2R) have emerged as promising targets for the diagnosis and therapy of brain pathologies. However, no suitable radiotracers for accurate CB2R mapping have been found to date, limiting the investigation of the CB2 receptor expression using positron emission tomography (PET) imaging. In this work, we report the evaluation of the in vivo expression of CB2R with [11C]A-836339 PET after cerebral ischemia and in two rat models of neuroinflammation, first by intrastriatal LPS and then by AMPA injection. PET images and in vitro autoradiography showed a lack of specific [11C]A-836339 uptake in these animal models demonstrating the limitation of this radiotracer to image CB2 receptor under neuroinflammatory conditions. Further, using immunohistochemistry, the CB2 receptor displayed a modest expression increase after cerebral ischemia, LPS and AMPA models. Finally, [18F]DPA-714-PET and immunohistochemistry demonstrated decreased neuroinflammation by a selective CB2R agonist, JWH133. Taken together, these findings suggest that [11C]A-836339 is not a suitable radiotracer to monitor in vivo CB2R expression by using PET imaging. Future studies will have to investigate alternative radiotracers that could provide an accurate binding to CB2 receptors following brain inflammation.
Clinical examination, critical care ultrasonography and outcomes in the critically ill: cohort profile of the Simple Intensive Care Studies-I

Purpose In the Simple Intensive Care Studies-I (SICS-I), we aim to unravel the value of clinical and haemodynamic variables obtained by physical examination and critical care ultrasound (CCUS) that currently guide daily practice in critically ill patients. We intend to (1) measure all available clinical and haemodynamic variables, (2) train novices in obtaining values for advanced variables based on CCUS in the intensive care unit (ICU) and (3) create an infrastructure for a registry with the flexibility of temporarily incorporating specific (haemodynamic) research questions and variables. The overall purpose is to investigate the diagnostic and prognostic value of clinical and haemodynamic variables. Participants The SICS-I includes all patients acutely admitted to the ICU of a tertiary teaching hospital in the Netherlands with an ICU stay expected to last beyond 24 hours. Inclusion started on 27 March 2015. Findings to date On 31 December 2016, 791 eligible patients fulfilled our inclusion criteria of whom 704 were included. So far 11 substudies with additional variables have been designed, of which six were feasible to implement in the basic study, and two are planned and awaiting initiation. All researchers received focused training for obtaining specific CCUS images. An independent Core laboratory judged that 632 patients had CCUS images of sufficient quality. Future plans We intend to optimise the set of variables for assessment of the haemodynamic status of the critically ill patient used for guiding diagnostics, prognosis and interventions. Repeated evaluations of these sets of variables are needed for continuous improvement of the diagnostic and prognostic models. Future plans include: (1) more advanced imaging; (2) repeated clinical and haemodynamic measurements; (3) expansion of the registry to other departments or centres; and (4) exploring possibilities of integration of a randomised clinical trial superimposed on the registry. Study registration number NCT02912624; Pre-results.
Impact of Coronary Artery Disease Severity Assessed With the SYNTAX Score on Outcomes Following Transcatheter Aortic Valve Replacement

Background The influence of coronary artery disease (CAD) on clinical and echocardiographic outcomes after transcatheter aortic valve replacement (TAVR) is still controversial. We sought to evaluate the impact of CAD severity as measured by the SYNTAX score (SS) on patients undergoing TAVR. Methods and Results A total of 377 patients who underwent TAVR in 2 high‐volume centers in North America were included in our retrospective analysis. A blinded angiographic core laboratory calculated the SS on all available coronary angiograms with the use of quantitative coronary analysis. Patients were stratified into 4 groups: (1) no CAD (SS=0); (2) low SS (SS between 1 and 22); (3) intermediate SS (SS between 23 and 32); and (4) high SS (SS ≥33). Patients who had undergone percutaneous coronary intervention within 6 months prior to TAVR were separated into 2 categories based on their residual SS (<8 and ≥8). Patients with previous coronary artery bypass grafting (CABG) were divided into 2 groups: (1) low CABG SS and (2) high CABG SS. The primary end point was a composite of all‐cause mortality, myocardial infarction, and stroke. At 30 days and 1 year, both the presence and the severity of CAD had no impact on the rate of the combined primary end point and on all‐cause mortality, cardiovascular mortality, and myocardial infarction. Patients with less complete revascularization (residual SS ≥8 versus residual SS <8 and low CABG SS versus high CABG SS, had similar rates of the combined primary end point, all‐cause mortality, cardiovascular mortality, MI, and stroke, at both 30 days and 1 year. Conclusions In our core laboratory–validated study, neither the severity of CAD nor completeness of revascularization after percutaneous coronary intervention or CABG were associated with clinical outcomes after TAVR, at both 30 days and 1 year.
Influence of provider experience on antiretroviral adherence and viral suppression

Background and aim Early in the combination antiretroviral therapy (cART) era, provider experience (as measured by panel size) was associated with improved outcomes. We explored that association and other characteristics of provider experience. Methods We performed a retrospective cohort analysis in Kaiser Permanente California (an integrated health care system in the United States), examining all human immunodeficiency virus seropositive (HIV+) patients initiating a first cART regimen (antiretroviral therapy [ART]-naïve, N = 7071) or initiating a second or later cART regimen (ART-experienced, N = 3730) from 1996–2006. We measured ART adherence through 12 months (pharmacy fill and refill records) and determined HIV viral load levels below limits of quantification at 12 months. Provider experience, updated annually, was measured as (1) HIV panel size (0–10 patients as reference strata), (2) years treating HIV (less than 1 year as reference), and (3) specialty ( noninfectious disease specialty, non-HIV expert as reference). We assessed associations by utilizing mixed modeling analyses (clustered by provider and medical center), controlling for patient age, sex, race/ethnicity, HIV risk behavior, hepatitis C coinfection, ART regimen class, and calendar year. Results Among the ART-experienced, improved adherence was associated with greater years experience (mean increase 3.1% 2–5 years experience; 3.7% 5–10 years; 2.7% 11–20 years; P = 0.07, categorical). In adjusted analyses, viral suppression among ART-naïve was positively associated with panel size (odds ratio 26–50 patients: 1.31, P = 0.03, categorical), but negatively associated with years experience (18% less for greater than 100 patients; P = 0.003). No provider characteristic was significantly associated with improved adherence among ART-naïve or odds of maximal viral suppression among ART-experienced in adjusted analysis. Conclusions Except for panel size and years experience among ART-naïve, provider characteristics did not significantly influence ART adherence or likelihood of viral suppression.
Does audiovisual distraction reduce dental anxiety in children under local anesthesia? A systematic review and meta-analysis.

OBJECTIVES To perform a systematic review and meta-analysis on the effects of audiovisual distraction on reducing dental anxiety in children during dental treatment under local anesthesia. METHODS The authors identified eligible reports published through August 2017 by searching PubMed, EMBASE, and Cochrane Central Register of Controlled Trials. Clinical trials that reported the effects of audiovisual distraction on children's physiological measures, self-reports, and behavior rating scales during dental treatment met the minimum inclusion requirements. The authors extracted data and performed a meta-analysis of appropriate articles. RESULTS Nine eligible trials were included and qualitatively analyzed; some of these trials were also quantitatively analyzed. Among the physiological measures, heart rate or pulse rate was significantly lower (p = .01) in children subjected to audiovisual distraction during dental treatment under local anesthesia than in those who were not; a significant difference in oxygen saturation was not observed. The majority of the studies using self-reports and behavior rating scales suggested that audiovisual distraction was beneficial in reducing anxiety perception and improving children's cooperation during dental treatment. CONCLUSION The audiovisual distraction approach effectively reduces dental anxiety among children. Therefore, we suggest the use of audiovisual distraction when children need dental treatment under local anesthesia.