Miracle-dz/UniFAR-FTUs huggingface dataset:
Subgraphs with Prescribed Valencies

In this paper a generalization of the factor problem for finite undirected graphs is detailed. We prescribe certain inequalities for the valencies of a subgraph. We deduce formulas for the minimum "deviation" of this prescription and characterize the "optimally approaching" subgraphs. These results include the conditions of Tutte and Ore for the existence of a factor and the characterization of maximal independent edge-systems given in [3] and [11]. Let us associate a non-negative integer f ( x ) with every vertex x o f a graph. 1 A subgraph is said to be an f-factor if its valency is f ( x ) in every vertex x. Here many problems arise: When does a graph contain an f fac to r? I f it does, how can these factors be characterized; if it does not, which are the subgraphs "approach ing" that wanted factor optimally ? Such problems were discussed first by Petersen. Two special cases were also discussed: the case o f 1-factors and the case o f bipartite graphs: these special questions can be considered to be solved essentially on the base o f many papers (see, e.g., references 1-5 and 7). In the general case Tutte gave a necessary and sufficient condition for the existence o f an f fac tor [8]. A different condition is due to Ore [6]. These conditions can be proved by the method of alternating path or by reducing the problem to the case o f a 1-factor [9]. In this paper we follow another method. We try to answer the questions asked above. We generalize the problem and prescribe for the valencies o f the wanted subgraph not an integer but an interval. 2 This generalization does not contain essentially more than the original problem, but it simplifies the discussion. A number 8 will be introduced to measure how 1 We consider finite undirected graphs. Directed graphs could be investigated similarly. Later (Section 1) we shall formulate this in a more symmetric way. 391
Serum From Patients With Acute Coronary Syndromes Displays a Proapoptotic Effect on Human Endothelial Cells: A Possible Link to Pan-Coronary Syndromes

Background—Endothelial apoptosis of atherosclerotic lesions is a possible determinant for the stable-to-vulnerable plaque transition. Recent data support the notion that plaque activation may be a pan-coronary process, advocating the existence of circulating triggers. Methods and Results—Serum from 40 healthy subjects (group 1) and 73 patients with stable angina (n=32; group 2) or acute coronary syndromes (n=41; group 3) was incubated with human umbilical vein endothelial cells. The percentage of apoptosis by flow cytometry and Fas, Bax, and Bcl-2 protein expression by immunoblotting were evaluated at entry in patients and control subjects and repeated after 12 months in group 3. At baseline, apoptotic nuclei were higher in group 3 (14±6%) than in group 2 (3.3±1.8%) and group 1 (1.35±0.8%) (P <0.001). Fas and Bcl-2 were increased in group 3 with respect to groups 1 and 2 (P <0.01). Coincubation of group 3 serum with anti–tumor necrosis factor-&agr; and anti–interleukin-6 monoclonal antibodies did not affect the human umbilical vein endothelial cell apoptotic process, whereas addition of Trolox decreased apoptosis to <50%. The percentage of apoptosis in group 3 significantly correlated to the numbers of coronary complex lesions at angiography (r =0.58, P <0.0005). In group 3, apoptosis and the Bax/Bcl-2 ratio decreased at 1 year (P <0.0001, P <0.05 respectively). Conclusions—Serum from patients with acute coronary syndromes displays a proapoptotic effect on human endothelial cells, supporting the theory of the existence of circulating triggers potentially able to activate atherosclerotic lesions.
A measurement study of GPU DVFS on energy conservation

Nowadays, GPUs are widely used to accelerate many high performance computing applications. Energy conservation of such computing systems has become an important research topic. Dynamic voltage/frequency scaling (DVFS) is proved to be an appealing method for saving energy for traditional computing centers. However, there is still a lack of firsthand study on the effectiveness of GPU DVFS. This paper presents a thorough measurement study that aims to explore how GPU DVFS affects the system energy consumption. We conduct experiments on a real GPU platform with 37 benchmark applications. Our results show that GPU voltage/frequency scaling is an effective approach to conserving energy. For example, by scaling down the GPU core voltage and frequency, we have achieved an average of 19.28% energy reduction compared with the default setting, while giving up no more than 4% of performance. For all tested GPU applications, core voltage scaling is significantly effective to reduce system energy consumption. Meanwhile the effects of scaling core frequency and memory frequency depend on the characteristics of GPU applications.
The relationship between egg size and helper number in cooperative breeders: a meta-analysis across species

Background Life history theory predicts that mothers should adjust reproductive investment depending on benefits of current reproduction and costs of reduced future reproductive success. These costs and benefits may in turn depend on the breeding female’s social environment. Cooperative breeders provide an ideal system to test whether changes in maternal investment are associated with the social conditions mothers experience. As alloparental helpers assist in offspring care, larger groups might reduce reproductive costs for mothers or alternatively indicate attractive conditions for reproduction. Thus, mothers may show reduced (load-lightening) or increased (differential allocation) reproductive investment in relation to group size. A growing number of studies have investigated how cooperatively breeding mothers adjust pre-natal investment depending on group size. Our aim was to survey these studies to assess, first, whether mothers consistently reduce or increase pre-natal investment when in larger groups and, second, whether these changes relate to variation in post-natal investment. Methods We extracted data on the relationship between helper number and maternal pre-natal investment (egg size) from 12 studies on 10 species of cooperatively breeding vertebrates. We performed meta-analyses to calculate the overall estimated relationship between egg size and helper number, and to quantify variation among species. We also tested whether these relationships are stronger in species in which the addition of helpers is associated with significant changes in maternal and helper post-natal investment. Results Across studies, there is a significant negative relationship between helper number and egg size, suggesting that in most instances mothers show reduced reproductive investment in larger groups, in particular in species in which mothers also show a significant reduction in post-natal investment. However, even in this limited sample, substantial variation exists in the relationship between helper number and egg size, and the overall effect appears to be driven by a few well-studied species. Discussion Our results, albeit based on a small sample of studies and species, indicate that cooperatively breeding females tend to produce smaller eggs in larger groups. These findings on prenatal investment accord with previous studies showing similar load-lightening reductions in postnatal parental effort (leading to concealed helper effects), but do not provide empirical support for differential allocation. However, the considerable variation in effect size across studies suggests that maternal investment is mitigated by additional factors. Our findings indicate that variation in the social environment may influence life-history strategies and suggest that future studies investigating within-individual changes in maternal investment in cooperative breeders offer a fruitful avenue to study the role of adaptive plasticity.
New Isocoumarin Derivatives and Meroterpenoids from the Marine Sponge-Associated Fungus Aspergillus similanensis sp. nov. KUFA 0013

Two new isocoumarin derivatives, including a new 5-hydroxy-8-methyl-2H, 6H-pyrano[3,4-g]chromen-2,6-dione (1) and 6,8-dihydroxy-3,7-dimethylisocoumarin (2b), a new chevalone derivative, named chevalone E (3), and a new natural product pyripyropene S (6) were isolated together with 6, 8-dihydroxy-3-methylisocoumarin (2a), reticulol (2c), p-hydroxybenzaldehyde, chevalone B, chevalone C, S14-95 (4), and pyripyropene E (5) from the ethyl acetate extract of the undescribed marine sponge-associated fungus Aspergillus similanensis KUFA 0013. The structures of the new compounds were established based on 1D and 2D NMR spectral analysis, and in the case of compound 3, X-ray analysis was used to confirm its structure and the absolute configuration of its stereogenic carbons. Compounds 1, 2a–c and 3–6 were evaluated for their antimicrobial activity against Gram-positive and Gram-negative bacteria, Candida albicans ATCC 10231, and multidrug-resistant isolates from the environment. Chevalone E (3) was found to show synergism with the antibiotic oxacillin against methicillin-resistant Staphylococcus aureus (MRSA).
Endoplasmic Reticulum Stress Contributes to Helicobacter Pylori VacA-Induced Apoptosis

Vacuolating cytotoxin A (VacA) is one of the important virulence factors produced by H. pylori. VacA induces apoptotic cell death, which is potentiated by ammonia. VacA also causes cell death by mitochondrial damage, via signaling pathways that are not fully defined. Our aim was to determine whether endoplasmic reticulum (ER) stress is associated with VacA-induced mitochondrial dysfunction and apoptosis. We found that C/EBP homologous protein (CHOP), a key signaling protein of ER stress-induced apoptosis, was transcriptionally up-regulated following incubation of gastric epithelial cells with VacA. The effect of VacA on CHOP induction was significantly enhanced by co-incubation with ammonium chloride. Phosphorylation of eukaryotic initiation factor 2 (eIF2)-alpha, which is known to occur downstream of the ER stress sensor PKR-like ER-localized eIF2-alpha kinase (PERK) and to regulate CHOP expression, was also observed following incubation with VacA in the presence of ammonium chloride. Knockdown of CHOP by siRNA resulted in inhibition of VacA-induced apoptosis. Further studies showed that silencing of the PERK gene with siRNA attenuated VacA-mediated phosphorylation of eIF2-alpha, CHOP induction, expression of BH3-only protein Bim and Bax activation, and cell death induced by VacA with ammonium chloride, indicating that ER stress may lead to mitochondrial dysfunction during VacA-induced toxicity. Activation of ER stress and up-regulation of BH3-only proteins were also observed in human H. pylori-infected gastric mucosa. Collectively, this study reveals a possible association between VacA-induced apoptosis in gastric epithelial cells, and activation of ER stress in H. pylori-positive gastric mucosa.
Integrated Assessment of Artisanal and Small-Scale Gold Mining in Ghana—Part 1: Human Health Review

This report is one of three synthesis documents produced via an integrated assessment (IA) that aims to increase understanding of artisanal and small-scale gold mining (ASGM) in Ghana. Given the complexities surrounding ASGM, an IA framework was utilized to analyze economic, social, health, and environmental data, and co-develop evidence-based responses with pertinent stakeholders. The current analysis focuses on the health of ASGM miners and community members, and synthesizes extant data from the literature as well as co-authors’ recent findings regarding the causes, status, trends, and consequences of ASGM in Ghana. The results provide evidence from across multiple Ghanaian ASGM sites that document relatively high exposures to mercury and other heavy metals, occupational injuries and noise exposure. The work also reviews limited data on psychosocial health, nutrition, cardiovascular and respiratory health, sexual health, and water and sanitation. Taken together, the findings provide a thorough overview of human health issues in Ghanaian ASGM communities. Though more research is needed to further elucidate the relationships between ASGM and health outcomes, the existing research on plausible health consequences of ASGM should guide policies and actions to better address the unique challenges of ASGM in Ghana and potentially elsewhere.
Diffusion and consumption of oxygen in the resting frog sartorius muscle

Adaptations of the method of Takahashi et al. (1966. J. Gen. Physiol. 50:317-333) were used to test the validity of the one-dimensional diffusion equation for O2 in the resting excised frog sartorius muscle. This equation is: (formula: see text) where x is the distance perpendicular to the muscle surface. t is time, P(x, t) is the partial pressure of O2,D and alpha are the diffusion coefficient and solubility for O2 in the tissue, and Q is the rate of O2 consumption. P(O, t), the time-course of PO2 at one muscle surface, was measured by a micro- oxygen electrode. Transients in the PO2 profile of the muscle were induced by two methods: (a) after an equilibration period, one surface was sealed off by a disc in which the O2 electrode was embedded; (b) when PO2 at this surface reached a steady state, a step change was made in the PO2 at the other surface. With either method, the agreement between the measured P(O, t) and that predicted by the diffusion equation was excellent, making possible the calculation of D and Q. These two methods yielded statistically indistinguishable results, with the following pooled means (+/- SEM): (formula: see text) At each temperature, D was independent of muscle thickness (range, 0.67-1.34 mm). The activation energy (EA) for diffusion of oxygen in muscle was - 3.85 kcal/mol, which closely matches the corresponding value in water. Together with absolute values of D in water taken from the literature, the present data imply that (Dmuscle/DH2O) is in the range 0.59-0.69. This value, and that of EA, are in agreement with the theory of Wang (1954, J. Am. Chem. Soc. 76:4755-4763), suggesting that with respects to the diffusion of O2, to a useful approximation, frog skeletal muscle may be considered simply as a homogeneous protein solution.
Educational Performance and Psychological Disengagement Among Ethnic-Minority and Dutch Adolescents

Abstract The authors used a questionnaire (N = 587) among ethnic-minority and majority group adolescents in The Netherlands to examine the idea that under certain conditions minority group members tend to psychologically disengage their self-evaluation from educational performance. The results showed that only among ethnic minorities, perceived discrimination in school was related to psychological disengagement. Furthermore, among both groups of participants, perceived diagnosticity of performance feedback was negatively related to disengagement. However, among the ethnic minority group this effect was found for only those participants with relatively high educational performance. The results showed that negative experiences in school can lead to psychological disengagement from the academic domain and that disengagement is not restricted to African American students.
Recruitment and Patch Establishment by Seed in the Seagrass Posidonia oceanica: Importance and Conservation Implications

Seagrasses are declining globally, and deeper understanding is needed on the recruitment potential and distribution of new populations for many threatened species to support conservation planning in the face of climate change. Recruitment of Posidonia oceanica, a threatened seagrass endemic to the Mediterranean, has long been considered rare due to infrequent flowering, but mounting evidence demonstrates that the species is responding to a changing climate through greater reproductive effort. Due to the fragmentary information on recruit occurrence and distribution, little is known about reproductive success in the species and its contribution to persistence. We assembled P. oceanica recruitment data from published and unpublished sources, including our own, to examine the frequency and extent of recruitment events (establishment of seedlings in a site), seedling growth potential and habitat characteristics at recruitment sites. Results show that at least one recruitment event has occurred about every 3 years, and 18 localities were colonized at least one time since the first seedling record in 1986. Notably, consistently high seedling inputs were observed in four localities of the Western Mediterranean. Seedlings established mainly on unoccupied substrate areas along the coasts of islands, in sheltered sites and at shallower depths (<3 m) than the upper limit of adjacent P. oceanica meadows. Seedling establishment occurred more frequently on rocky than on sandy substrate, and rarely on dead “matte” or meadows of the seagrass Cymodocea nodosa. The chance of colonization success on rock was two times higher than on sand. Our 11 years of observations have allowed for the first time the documentation of the formation and development of patches by P. oceanica seed. These findings contradict the historical assumption that sexual recruitment is rare and usually unsuccessful for P. oceanica, and highlight the potential importance of recruitment for the long-term persistence and adaptation of the species to sea level rise predicted in the next century in the Mediterranean. Unfortunately, management actions have mainly focused on established meadows, ignoring the presence of recruits in outside areas. Therefore, it will be useful to identify and consider regeneration sites in designing future management strategies to improve seagrass conservation effectiveness.
Development of a mariner-Based Transposon and Identification of Listeria monocytogenes Determinants, Including the Peptidyl-Prolyl Isomerase PrsA2, That Contribute to Its Hemolytic Phenotype

ABSTRACT Listeriolysin O (LLO) is a pore-forming toxin that mediates phagosomal escape and cell-to-cell spread of the intracellular pathogen Listeria monocytogenes. In order to identify factors that control the production, activity, or secretion of this essential virulence factor, we constructed a Himar1 mariner transposon delivery system and screened 50,000 mutants for a hypohemolytic phenotype on blood agar plates. Approximately 200 hypohemolytic mutants were identified, and the 51 most prominent mutants were screened ex vivo for intracellular growth defects. Eight mutants with a phenotype were identified, and they contained insertions in the following genes: lmo0964 (similar to yjbH), lmo1268 (clpX), lmo1401 (similar to ymdB), lmo1575 (similar to ytqI), lmo1695 (mprF), lmo1821 (similar to prpC), lmo2219 (prsA2), and lmo2460 (similar to cggR). Some of these genes are involved in previously unexplored areas of research with L. monocytogenes: the genes yjbH and clpX regulate the disulfide stress response in Bacillus subtilis, and the prpC phosphatase has been implicated in virulence in other gram-positive pathogens. Here we demonstrate that prsA2, an extracytoplasmic peptidyl-prolyl cis/trans isomerase, is critical for virulence and contributes to the folding of LLO and to the activity of another virulence factor, the broad-range phospholipase C (PC-PLC). Furthermore, although it has been shown that prsA2 expression is linked to PrfA, the master virulence transcription factor in L. monocytogenes pathogenesis, we demonstrate that prsA2 is not directly controlled by PrfA. Finally, we show that PrsA2 is involved in flagellum-based motility, indicating that this factor likely serves a broad physiological role.
An Evidentiary Paradox: Defending the Character Evidence Prohibition by Upholding a Non-Character Theory of Logical Relevance, the Doctrine of Chances

In the past 35 years, the doctrine of objective chances has emerged as one of the most important non-character theories of logical relevance. When a person suffers a particular type of loss with extraordinary frequency, the coincidence is circumstantial evidence that one or some of the incidents were not accidents. The courts accept the evidence because the relevance of the evidence arguably rests on the objective improbability of so many accidents rather than any assumptions about the defendant's personal, subjective bad character. When a civil rights plaintiff wants to prove discriminatory animus, she frequently offers evidence of other allegedly discriminatory acts by the defendant. When an accused denies any knowledge of drugs found in an automobile he was driving, the prosecutor often presents testimony about other occasions when the accused was arrested with drugs in his possession. Perhaps most importantly, in a child abuse prosecution in which the accused claims that the child's injury was accidental, the prosecutor typically offers testimony about other injuries sustained by that child or other children in the accused's custody. The probative value of the evidence seems so obvious that many would regard it as an affront to common sense to exclude the evidence. However, in the past ten years, there has been growing criticism that the doctrine of chances lacks legitimate non-character relevance. The thrust of the criticism is that evidence admitted under the doctrine is irrelevant unless one assumes that the defendant has a constant, unchanging propensity over time. If based on that criticism the courts begin to exclude the evidence admitted in the past under the doctrine, that development will increase the pressure to abolish what remains of the character evidence prohibition. Within the past decade, Congress has selectively abolished the prohibition in sexual assault and child molestation cases; and 10 states have followed suit. If the courts begin to routinely exclude this highly probative evidence in child abuse prosecutions and civil rights actions, as a backlash the character evidence prohibition itself might be abolished. The thesis of this article is that the criticisms of the doctrine of chances are mistaken. The article argues that evidence admitted under the doctrine possesses genuine non-character relevance. The criticisms rest on a simplistic, determinist view of human behavior. Doctrine of chances reasoning enables the trier of fact to negatively reject the hypothesis that random chance accounts for all the outcomes. By allowing the trier to reject that hypothesis, the evidence affirmatively increases the probability that one or some of the incidents are the product of situational choice, not prompted by the person's character traits. There may be a case for abolishing the character evidence prohibition, but that case cannot be premised on the argument that the doctrine of chances is a spurious non-character theory.
Rough Clustering Using an Evolutionary Algorithm

Cluster analysis is a fundamental technique in traditional data analysis and many clustering methods have been identified, including the commonly used k-means approach, which requires the number of clusters to be specified in advance and is dependent on initial starting points. We present an evolutionary-based rough clustering algorithm, which is designed to overcome these limitations. Rough clusters are defined in a similar manner to Pawlak's rough set concept, with a lower and upper approximation, allowing multiple cluster membership for objects in the data set. The paper describes the template, the data structure used to describe rough clusters. It also provides an overview of the evolutionary algorithm used to develop viable cluster solutions, consisting of an optimal number of templates providing descriptions of the clusters. This algorithm was tested on a small data set and a large data set.