Miracle-dz/UniFAR-FTUs huggingface dataset:
A qualitative study of client experiences of working with novice counsellors

Aims: This paper reports on a qualitative analysis of written accounts by clients who participated in a counselling relationship with beginning-level trainees. The purpose of the study was to explore how clients experience the process of counselling with novice practitioners. Method: Consensual qualitative research was used for data analysis. Findings: Three general thematic categories were identified – client perceptions of self in counselling; client perceptions of the counsellor; and client perception of the counselling process. Conclusions: Overall, the findings suggest that these clients saw the interpersonal qualities and skills of the counsellor as major contributors to their experience. Implications: Clinical training of novices should start by developing the interpersonal and collaborative skills of trainees.
Quality of life and voice in patients treated for early laryngeal cancer.

OBJECTIVES To evaluate quality of life and voice in patients previously treated for early laryngeal cancer versus healthy controls and to assess correlations between demographic and cancer characteristics and posttreatment quality of life and voice. MATERIAL AND METHODS A total of 49 patients diagnosed with early (Tis-T2N0) laryngeal carcinoma, treated by radiotherapy or endoscopic surgery at least 6 months before, who were alive and free of recurrence formed study group. Postservice with questionnaires was accomplished. Quality of life was evaluated using Medical Outcomes Study 36-Item Health Survey (SF-36), Hospital Anxiety and Depression (HAD) Scale, voice quality--by Voice Handicap Index (VHI). Normative data were obtained from database or concurrently assessed healthy adult subjects. RESULTS Hoarseness was the most frequent complain. Majority of patients consider their health as fair (69.4%), one third--good or excellent. The means of summary of SF-36 scores for physical and mental health differ significantly from normative age-matched population (P<0.001). Emotional distress on HAD scale was found in 40.8% of patients vs. 17.0% of healthy controls. Majority (87.8%) of patients rated their voice abnormal; vast majority of them had slight to moderate dysfunction. Mean VHI scores were slight elevated for patients and differed significantly from healthy ones. Correlation analysis revealed a significant relationship between patients' physical health and some demographic-clinic factors. CONCLUSIONS Quality of life in patients previously treated for early laryngeal cancer was worse than healthy subjects. Psychiatric morbidity was indicated in around of one-third of the patients. Voice changes were reported in most patients with low handicap level. Physical health perception was better for patients with higher grade of cancer differentiation, not using alcohol, and treated first.
Socioemotional Wealth and Corporate Responses to Institutional Pressures: Do Family-Controlled Firms Pollute Less?

This paper compares the environmental performance of family and nonfamily public corporations between 1998 and 2002, using a sample of 194 U.S. firms required to report their emissions. We found that family-controlled public firms protect their socioemotional wealth by having a better environmental performance than their nonfamily counterparts, particularly at the local level, and that for the nonfamily firms, stock ownership by the chief executive officer (CEO) has a negative environmental impact. We also found that the positive effect of family ownership on environmental performance persists independently of whether the CEO is a family member or serves both as CEO and board chair.
Vitamin-Like Supplementation in Dairy Ruminants: The Case of Choline

Recent developments in nutrition have established that choline is an essential nutrient for mammals when a sufficient supply in methionine and folates are not available in the diet. Vitamin B12 is also involved in this process. The dynamic interactions between these components introduced the concept of choline as vitamin-like compound. Two types of choline functions are known: as choline per se, for which the choline moiety is required, and functions as a methyl donor. Choline per se plays a major role in lipid metabolism, particularly in lipid transport, as lipotropic agent. Choline is also an important source of labile methyl groups for the biosynthesis of other methylated compounds. Based on this second function choline and methionine are interchangeable, as sources of methyl groups. Accordingly choline occupies a key position between energy and protein metabolism in mammals.
Advanced Mathematical-Thinking at Any Age: Its Nature and Its Development

This article argues that advanced mathematical thinking, usually conceived as thinking in advanced mathematics, might profitably be viewed as advanced thinking in mathematics (advanced mathematical-thinking). Hence, advanced mathematical-thinking can properly be viewed as potentially starting in elementary school. The definition of mathematical thinking entails considering the epistemological and didactical obstacles to a particular way of thinking. The interplay between ways of thinking and ways of understanding gives a contrast between the two, to make clearer the broader view of mathematical thinking and to suggest implications for instructional practices. The latter are summarized with a description of the DNR system (Duality, Necessity, and Repeated Reasoning). Certain common assumptions about instruction are criticized (in an effort to be provocative) by suggesting that they can interfere with growth in mathematical thinking.
Changes in mitochondrial function during EMT induced by TGFβ-1 in pancreatic cancer

Mitochondrial dysfunction is linked to cancer. Differences in the number, morphology and function of mitochondria have been observed between normal cells and cancer cells. However, changes in mitochondrial function during epithelial-mesenchymal transition (EMT) in pancreatic cancer are less known. In the present study, the cultured human pancreatic cancer cell line Panc-1 was treated with transforming growth factor (TGF)β-1. Mitochondrial functions following TGFβ-1 exposure in pancreatic cancer were investigated. It was noticed that TGFβ-1 treatment induces morphologic changes and a shift from epithelial to mesenchymal phenotype in pancreatic cancer. Furthermore, increased mitochondrial mass was detected in pancreatic cancer following TGFβ-1 treatment. Besides, the production of reactive oxygen species in TGFβ-1-treated pancreatic cancer cells significantly increased compared with the control cells. Our results indicate that the phenomenon of EMT in pancreatic cancer has an association with mitochondrial dysfunction. Mitochondrial dysfunction may be a cause of EMT in pancreatic cancer, which leads to heterogeneity in pancreatic cancer, and may be a potential therapeutic target in the future.
Hepatic Heme-Regulated Inhibitor (HRI) Eukaryotic Initiation Factor 2α Kinase: A Protagonist of Heme-Mediated Translational Control of CYP2B Enzymes and a Modulator of Basal Endoplasmic Reticulum Stress Tone

We have reported previously that the hepatic heme-regulated inhibitor (HRI)-eukaryotic initiation factor 2α (eIF2α) kinase is activated in acute heme-deficient states, resulting in translational shut-off of global hepatic protein synthesis, including phenobarbital (PB)-mediated induction of CYP2B enzymes in rats. These findings revealed that heme regulates hepatic CYP2B synthesis at the translational level via HRI. As a proof of concept, we have now employed a genetic HRI-knockout (KO) mouse hepatocyte model. In HRI-KO hepatocytes, PB-mediated CYP2B protein induction is no longer regulated by hepatic heme availability and proceeds undeterred even after acute hepatic heme depletion. It is noteworthy that genetic ablation of HRI led to a small albeit significant elevation of basal hepatic endoplasmic reticulum (ER) stress as revealed by the activation of ER stress-inducible RNA-dependent protein kinase-like ER-integral (PERK) eIF2α-kinase, and induction of hepatic protein ubiquitination and ER chaperones Grp78 and Grp94. Such ER stress was further augmented after PB-mediated hepatic protein induction. These findings suggest that HRI normally modulates the basal hepatic ER stress tone. Furthermore, because HRI exists in both human and rat liver in its heme-sensitive form and is inducible by cytochrome P450 inducers such as PB, these findings are clinically relevant to acute heme-deficient states, such as the acute hepatic porphyrias. Activation of this exquisitely sensitive heme sensor would normally protect cells by safeguarding cellular energy and nutrients during acute heme deficiency. However, similar HRI activation in genetically predisposed persons could lead to global translational arrest of physiologically relevant enzymes and proteins, resulting in the severe and often fatal clinical symptoms of the acute hepatic porphyrias.
Neighbourhood ethnic composition and voting for the radical right in the Netherlands: The role of perceived neighbourhood threat and interethnic neighbourhood contact

Support for radical right parties has grown rapidly in many Western countries over the past few decades. In recent years, many studies have addressed the relationship between the presence of ethnic minorities in people's living environment and their support for a radical right party, but consensus is hard to find as to how ethnic minority density is related to support for the radical right, let alone why. In this contribution, we demonstrate that in The Netherlands, ethnic minority density is positively related to the likelihood to vote for the Party for Freedom. This is particularly the case when the size of the minority group exceeds 15 per cent of the total neighbourhood population. We could establish this relationship by using the Dutch 1Vandaag Opinion Panel data set, a unique large-scale, individual-level data set comprising 21,200 native Dutch respondents living in 3,068 different neighbourhoods. We enriched this data set with contextual information derived from Statistics Netherlands. The reason why ethnic minority density is linked to support for the radical right is that these residents see non-Western migrants as a threat for their neighbourhood. This is particularly true for residents who do not mingle with their non-coethnic neighbours.
Detection of autoantibodies to killer immunoglobulin-like receptors using recombinant fusion proteins for two killer immunoglobulin-like receptors in patients with systemic autoimmune diseases.

OBJECTIVE To investigate the existence of autoantibodies to killer immunoglobulin-like receptors (KIRs), especially p58.1 (KIR2DL1) and p58.2 (KIR2DL3), in patients with systemic autoimmune diseases. METHODS Sera from 30 patients with systemic lupus erythematosus (SLE), 30 patients with rheumatoid arthritis (RA), 22 patients with Behçet's disease, and 20 healthy control subjects were tested for anti-p58.1 and anti-p58.2 antibodies by Western blot analysis using recombinant p58.1 and p58.2 proteins. Furthermore, clinical features and laboratory data were compared between the anti-p58.1/58.2 antibody-positive and -negative patients. RESULTS Anti-p58.1 antibodies were detected in 7 (23.3%) of the 30 patients with SLE, 9 (30%) of the 30 patients with RA, and 6 (27.3%) of the 22 patients with Behçet's disease. Anti-p58.2 antibodies were detected in the same 22 patients who were positive for the anti-p58.1 antibodies. None of the serum samples from the healthy donors were positive for antibodies to the recombinant p58.1 or p58.2 molecules. Compared with the anti-p58.1/ 58.2 antibody-negative patients, the anti-p58.1/58.2 antibody-positive patients had significantly elevated levels of serum IgG in all 3 diseases tested, an accelerated erythrocyte sedimentation rate in RA and SLE, and decreased white blood cell counts in RA. CONCLUSION This report is the first to describe the presence of autoantibodies to KIR2DL (p58.1 and p58.2) in the sera of patients with systemic autoimmune diseases. Considering the correlation with several clinical features, these autoantibodies may be involved in the pathologic process of the autoimmune diseases.
Motor outcome prediction using diffusion tensor tractography of the corticospinal tract in large middle cerebral artery territory infarct.

BACKGROUND Middle cerebral artery (MCA) territory infarct is the most common type of cerebral vascular territory infarct. Accurate prediction of motor outcome is important for stroke rehabilitation. OBJECTIVES We conducted an investigation of prognostic factors of motor outcome in patients with a large MCAterritory infarction, using diffusion tensor tractography (DTT) of the corticospinal tract (CST). METHODS A total of 37 consecutive hemiparetic patients with a large MCA territory infarct were recruited for this study; DTT was performed within 5-30 days after onset. Patients were classified into three groups according to DTT findings: in group A - CST integrity was preserved around infarct regions, in group B - CSTs were discontinuous, and, in group C - the upper ends of CSTs did not reach infarcted regions. Fractional anisotropy (FA) ratio of the affected CST (versus the unaffected ipsilateral CST) was calculated, and evaluation of motor function was performed using the Motricity Index (MI), modified Brunnstrom classification (MBC) score, and the functional ambulation category (FAC) score at onset and at six months after onset. RESULTS Significantly greater changes in motor function (MI, MBC, and FAC) were observed between onset and six months post-onset in group A, compared with groups B and C (p < 0.05). However, no significant difference was observed between groups B and C (p > 0.05). FA ratios showed positive correlation with six-month MIs, and scores for MBC and FAC (p < 0.05). CONCLUSIONS Results of this study demonstrate the usefulness of early DTT findings of CSTs for prediction of motor outcome in patients with a large MCA territory infarct.
ZINC - A Free Database of Commercially Available Compounds for Virtual Screening

A critical barrier to entry into structure-based virtual screening is the lack of a suitable, easy to access database of purchasable compounds. We have therefore prepared a library of 727,842 molecules, each with 3D structure, using catalogs of compounds from vendors (the size of this library continues to grow). The molecules have been assigned biologically relevant protonation states and are annotated with properties such as molecular weight, calculated LogP, and number of rotatable bonds. Each molecule in the library contains vendor and purchasing information and is ready for docking using a number of popular docking programs. Within certain limits, the molecules are prepared in multiple protonation states and multiple tautomeric forms. In one format, multiple conformations are available for the molecules. This database is available for free download (http://zinc.docking.org) in several common file formats including SMILES, mol2, 3D SDF, and DOCK flexibase format. A Web-based query tool incorporating a molecular drawing interface enables the database to be searched and browsed and subsets to be created. Users can process their own molecules by uploading them to a server. Our hope is that this database will bring virtual screening libraries to a wide community of structural biologists and medicinal chemists.
Attribute information and the feeling-of-knowing

It has been demonstrated that Iceling-of-knowing judgements about unrecallcd items predict subsequent recognition performance with above-chance accuracy, but little is understood about the basis of the feeling of knowing. The present experiment examined the hypothesis that subjects' tendency to make positive fecling-of-knowing judgements depends upon gaining access to attribute information concerning unrecalled items. Results indicated that when subjects made positive feeling-of-knowing judgements, attribute identification was more accurate than when subjects made negative feeling-of-knowing judgements. However, it was also observed that subjects tended to make positive fcclingof-knowing judgements when they were confident that they had retrieved an attribute of an unrecallcd item, even when attribute retrieval was inaccurate. Implications for an attribute view of the feeling of knowing are discussed.
Auditory cortical processing in noise in younger and older adults

Abstract Objective: A common clinical complaint among older adults is difficulty hearing in noise, even in those with normal or near-normal peripheral hearing sensitivity. Researchers have demonstrated behavioral hearing in noise deficits in older adults, but to date limited evidence, particularly objective, exists elucidating the effects of age on auditory cortical processing in noise. The purpose of this investigation was to explore age related differences in auditory cortical processing at multiple signal-to-noise ratios (SNRs). Study design: Twenty normal-hearing young adults and 15 normal-hearing older adults participated in the study. Late auditory evoked potential (N1 and P2) latencies and amplitudes were measured in quiet and at three signal-to-noise ratios (SNRs) (+ 20, + 10, and 0 SNR). Repeated measures analyses of variance (ANOVA) were utilized to determine if statistically significant differences existed. Results: Significant group by listening condition interactions existed for N1 and P2 amplitudes. P2 latencies were significantly longer for the older adult group compared to the younger adult group. In addition, N1 and P2 amplitudes were significantly smaller for the younger adult group compared to the older adult group. Conclusion: Results suggest a possibly greater reduction in the synchronous neuronal response from quiet to noisy conditions in older adults than in younger adults.
Exploring the Effects of Environmental Experience on Attachment to Urban Natural Areas

This study explored the relationship between place attachment and both environmental experience and environmental attributes within three urban natural areas in Michigan. To understand these relationships, 328 park users—including neighbors, visitors, volunteers, and staff—were asked about their attachment, use, environmental knowledge, and attitudes toward management using a photo questionnaire. The results showed that attachment has different manifestations related to experience—a place-specific attachment was generally held by neighbors and recreational users, whereas a conceptual attachment was held by volunteers, staff, and those with extensive natural-areas knowledge. Each form of attachment was associated with distinctive perspectives on management. The study showed that the expert’s vision of appropriate management of a natural area may differ from those of neighbors and users, which can readily lead to conflict. If, however, attachment is recognized as a multifaceted and far-reaching component of people’s relationship to a place, such conflicts can be mitigated.
Optimizing antimetabolite‐based chemotherapy for the treatment of childhood acute lymphoblastic leukaemia

Therapy with antimetabolites forms an important part of the treatment of childhood acute lymphoblastic leukaemia (ALL). However, the use of these agents varies for dose, route and schedule of administration world-wide. Although the overall survival rates for children receiving predominantly antimetabolite-based therapy (Veerman et al, 1996) and regimens containing anthracyclines and alkylating agents (Reiter et al, 1994) are similar, the pharmacological guidance of antimetabolite-based therapy in childhood ALL has been shown to be associated with improved survival (Evans et al, 1998). Moreover, the high lymphoid marrow relapse-free survival reported by Winick et al (1996) for children receiving a treatment regimen containing intensive oral methotrexate, oral 6-mercaptopurine and intravenous etoposide and cytosine arabinoside are among the highest reported to date. The optimization of antimetabolite-based therapy using schedules of administration which are based on the known clinical and cellular pharmacological properties of these agents may further improve the survival of childhood acute leukaemia. The purpose of this review will be to discuss the possible optimization of methotrexate, cytosine arabinoside, thiopurines and epipodophyllotoxins in the therapy of childhood ALL. For this, the discussion will focus on the known mechanisms of cytotoxicity of these agents in vitro, on their activity as single agents and on studies of the clinical and cellular pharmacology of these agents in the therapy of childhood ALL.
What do we talk about when we talk about rhythm?

1 Department of Psychology, University of Lübeck, Lübeck, Germany, 2 Brain and Mind Institute, Department of Psychology, The University of Western Ontario London, Ontario, Canada, 3 Cognitive Neuroscience and Schizophrenia Program, Nathan Kline Institute, Orangeburg, New York, United States of America, 4 Department of Psychiatry, New York University School of Medicine, New York, New York, United States of America
Assessment of the Mass Balance Recovery and Metabolite Profile of Avibactam in Humans and In Vitro Drug-Drug Interaction Potential

Avibactam, a novel non-β-lactam β-lactamase inhibitor with activity against Ambler class A, class C, and some class D enzymes is being evaluated in combination with various β-lactam antibiotics to treat serious bacterial infections. The in vivo mass balance recovery and metabolite profile of [14C] avibactam (500 mg/1-h infusion) was assessed in six healthy male subjects, and a series of in vitro experiments evaluated the metabolism and drug-drug interaction potential of avibactam. In the mass balance study, measurement of plasma avibactam (using a validated liquid chromatography-tandem mass spectrometry method) and total radioactivity in plasma, whole blood, urine, and feces (using liquid scintillation counting) indicated that most of the avibactam was excreted unchanged in urine within 12 hours, with recovery complete (>97% of the administered dose) within 96 hours. Geometric mean avibactam renal clearance (158 ml/min) was greater than the product of unbound fraction of drug and glomerular filtration rate (109.5 ml/min), suggesting that active tubular secretion accounted for some renal elimination. There was no evidence of metabolism in plasma and urine, with unchanged avibactam the major component in both matrices. Avibactam demonstrated in vitro substrate potential for organic anion transporters 1 and 3 (OAT1 and OAT3) proteins expressed in human embryonic kidney 293 cells (Km > 1000 μM; >10-fold the Cmax of a therapeutic dose), which could account for the active tubular secretion observed in vivo. Avibactam uptake by OAT1 and OAT3 was inhibited by probenecid, a potent OAT1/OAT3 inhibitor. Avibactam did not interact with various other membrane transport proteins or cytochrome P450 enzymes in vitro, suggesting it has limited propensity for drug–drug interactions involving cytochrome P450 enzymes.
THE GOULD’S BELT DISTANCES SURVEY (GOBELINS). III. THE DISTANCE TO THE SERPENS/AQUILA MOLECULAR COMPLEX

We report on new distances and proper motions to seven stars across the Serpens/Aquila complex. The observations were obtained as part of the Gould’s Belt Distances Survey (GOBELINS) project between 2013 September and 2016 April with the Very Long Baseline Array (VLBA). One of our targets is the proto-Herbig AeBe object EC 95, which is a binary system embedded in the Serpens Core. For this system, we combined the GOBELINS observations with previous VLBA data to cover a total period of 8 years, and derive the orbital elements and an updated source distance. The individual distances to sources in the complex are fully consistent with each other, and the mean value corresponds to a distance of 436.0 ± 9.2 pc for the Serpens/W40 complex. Given this new evidence, we argue that Serpens Main, W40, and Serpens South are physically associated and form a single cloud structure.