Miracle-dz/UniFAR-FTUs huggingface dataset:
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sychological trauma can result from witnessing an event that is perceived to be life-threatening or to pose the potential of serious bodily injury to self or others. Such experiences, which are often accompanied by intense fear, horror, and helplessness, can lead to the development of, and are required for the diagnosis of, post-traumatic stress disorder (PTSD). It was originally thought that PTSD represented a normative response, at the extreme end of a response continuum, the severity of which related primarily to trauma/stressor intensity. However, it has become clear over time that the response of an individual to trauma depends not only on stressor characteristics, but also on factors specific to the individual. For the vast majority of the population, the psychological trauma brought about by the experience of profound threat is limited to an acute, transient disturbance. Though transient, such reactions can be quite unpleasant and are typically characterized by phenomena that can be grouped for the most part into three primary domains: (i) reminders of the exposure (including S t a t e o f t h e a r t
The influence of Ulrich Beck’s work on social-environmental studies in Brazil

This short article aims to reflect on the impacts of Ulrich Beck’s work in Brazilian sociology. Particularly, it will be argued that Beck’s work has had a significant impact on the establishment of the conceptual field of environmental sociology in Brazil. His book Risk Society, for instance, had a great influence – since the late 1980s – among the Brazilian research groups dedicated to the debate on the relationship between society and nature in modern contexts. Although placed in the critical target condition through the years, the notion of risk developed by Beck is still undoubtedly an important pillar in the constitution of the field of socioenvironmental studies at an international level and in Brazil, in particular.
Unusual functional manifestations of a novel STX11 frameshift mutation in two infants with familial hemophagocytic lymphohistiocytosis type 4 (FHL4)

Familial hemophagocytic lymphohistiocytosis (FHL) is typically an autosomal recessive, early‐onset, life‐threatening immune disorder. Loss‐of‐function mutations in STX11 have been found to impair NK cell degranulation and cytotoxicity. Here, we describe two unrelated infants of Punjabi descent presenting with FHL and carrying a novel, homozygous STX11 frameshift mutation [c.867dupG]. Western blot analysis indicated absence of syntaxin‐11. Unexpectedly, degranulation by NK cells from one of the patients was not impaired, although patient NK cells showed mildly and significantly decreased cytotoxicity, respectively. Importantly, these observations imply that STX11 should be sequenced in HLH patients even when impaired NK cell degranulation is not found. Pediatr Blood Cancer 2011;56:654–657. © 2010 Wiley‐Liss, Inc.
Projection defocus correction using adaptive kernel sampling and geometric correction in dual-planar environments

Defocus blur correction for projectors using a camera is useful when the projector is used in ad hoc environments. However, past literature has not explicitly considered the common situation when the projection surface includes a corner made up of two planar surfaces that abut each other, such as the ubiquitous office cubicle. In this paper, we advance the state of the art by demonstrating defocus correction in a non-parametric setting. Our method differs from prior methods in that (a) the luminance and chrominance channels are independently considered, and (b) a sparse sampling of the surface is used to discover the spatially varying defocus kernel.
Novel Pharmacokinetic-Pharmacodynamic Model for Prediction of Outcomes with an Extended-Release Formulation of Ciprofloxacin

ABSTRACT The pharmacokinetics of an extended-release (XR) formulation of ciprofloxacin has been compared to that of the immediate-release (IR) product in healthy volunteers. The only significant difference in pharmacokinetic parameters between the two formulations was seen in the rate constant of absorption, which was approximately 50% greater with the IR formulation. The geometric mean plasma ciprofloxacin concentrations were applied to an in vitro pharmacokinetic-pharmacodynamic model exposing three different clinical strains of Escherichia coli (MICs, 0.03, 0.5, and 2.0 mg/liter) to 24 h of simulated concentrations in plasma. A novel mathematical model was derived to describe the time course of bacterial CFU, including capacity-limited replication and first-order rate of bacterial clearance, and to model the effects of ciprofloxacin concentrations on these processes. A “mixture model” was employed which allowed as many as three bacterial subpopulations to describe the total bacterial load at any moment. Comparing the two formulations at equivalent daily doses, the rates and extents of bacterial killing were similar with the IR and XR formulations at MICs of 0.03 and 2.0 mg/liter. At an MIC of 0.5 mg/liter, however, the 1,000-mg/day XR formulation showed a moderate advantage in antibacterial effect: the area under the CFU-time curve was 45% higher for the IR regimen; the nadir log CFU and 24-h log CFU values for the IR regimen were 3.75 and 2.49, respectively; and those for XR were 4.54 and 3.13, respectively. The mathematical model explained the differences in bacterial killing rate for two regimens with identical AUC/MIC ratios.
A protocol for assessment of risk in wheelchair driving within a healthcare facility

Purpose: The purpose of this article is to describe how a skilled nursing facility with significant wheelchair traffic developed a protocol for the multidisciplinary assessment and intervention management of patients whose wheelchair use represents a risk to self and others. This article describes the procedure and two case studies illustrating the utility of the protocol. Method: Staff of the facility developed a protocol for responding to sentinel events related to patients hurting themselves and others while using a wheelchair or observed using the wheelchair in an unsafe manner. The goal of the protocol is to determine the cause of the event, identify the necessary multidisciplinary interventions, and the evaluation of the effectiveness of the interventions. Results: Case study analysis of the interventions indicated that a multidisciplinary evaluation and treatment plan leads to treatment interventions that suit the patient's medical condition while affording the patient the greatest amount of independence. Conclusion: Many patients who live in a long-term skilled nursing facility must use either a manual or a power wheelchair for mobility. For these patients, the wheelchair may represent one of the last forms of independence they enjoy. The implementation of the protocol helped staff respond to important changes to the patient's condition and prepare a coordinated intervention. The patients found the protocol to be a helpful component of their treatment.
Frequência do uso de psicofármacos entre jovens estudantes que cursam pré-vestibular

Objective:This study explores the use of psychoactive drugs among pupils between 17 and 21 years old in university entrance courses, according to their selected academic fi elds. Methods: Forms were distributed to random classes at two leading university entrance schools, for voluntary completion by these pupils, preserving their anonymity. Results: The total sample consisted of 886 pupils, completing the forms in the presence of the researcher, who collected each form as it was completed. it was ascertained that 182 pupils take some type of psychoactive drug, separated into pharmacological groups, with anti-depressants being the most widely used. The highest rate was among the 21 year-olds, with no signifi cant statistical difference among their selected academic fi elds and psychoactive drug use. The chi-square test for independence indicates that taking psychoactive drugs and selected academic fi elds are not related (p-value: 0.117). Conclusion: This leads to the conclusion that psychoactive drug use is high among university entrance course pupils, refl ecting diffi culties in coping with increasingly keener competition, social and family pressures, doubts about choice of profession and other anxieties that might be age-related or could be linked to other factors. A serious problem of self-medication with psychoactive drugs was noted, despite restricted sales and retained prescriptions, which can have severe and unexpected consequences. Some questions were raised about the use of these drugs and the factors triggering their use.
Phenotypic Basis of Reproductive Success in a Social Insect: Genetic and Social Determinants

Social insects live in societies that include both reproductive and nonreproductive adults. Understanding the factors that determine which individuals become successful reproductives is necessary to explain the evolution of these societies. The phenotypic effects of the gene Pgm-3 (or a closely linked gene) that may cause workers of the fire ant Solenopsis invicta to selectively execute all queens of a specific genotype were investigated. These effects, which involve differences in queen reproductive development, are expressed only in colonies exhibiting a particular type of social organization (multiple-queen colonies), and it is only in such colonies that selective execution on the basis of genotype occurs. This is an unusual example of genotype-environment interaction in gene expression in which the environmental component is the social environment. The queens executed are, surprisingly, those with the greatest reproductive development. Thus, there is a counterintuitive relation between the potential and realized reproductive success of queens in multiple-queen societies of this ant.
Defining Down Sovereignty: The Rights and Responsibilities of Nations

“Defining down sovereignty” refers to the normative thesis that sovereignty should not grant a state absolute protection against armed intervention in its internal affairs by other states, and that instead the international community should condition such immunity on states living up to particular standards. This essay suggests two modifications to this thesis. First, the international community should spell out the kinds of failures to protect civilians that can justify armed interventions by other states, as well as which agency has the authority to determine when such failures have occurred. In other words, the international community should determine how low to set the bar for intervention, and who makes the rules. Second, the international community needs to establish an additional international responsibility, namely, a responsibility to prevent international terrorism. The essay treats both of these modifications as shared international normative understandings; it does not attempt to translate these changes into international law.
The Boundaries of the Firm Revisited

Both transaction cost-economics and property-rights theories offer explanations of the boundaries of the firm based on ideas of ex post bargaining and holdup. These theories are quite distinct in their empirical predictions, but neither offers a satisfactory account of a large variety of observed practices. The authors discuss a number of such examples, where the boundaries of the firm seem to be determined by factors other than the need to protect investments, and where other mechanisms than the allocation of asset ownership are used to provide investment incentives. These examples indicate the need to enrich their theory of firm boundaries.
Different battlegrounds, similar concerns? The ‘history wars’ and the teaching of history in Australia and England

Debates about the purpose and content of history education in schools have been prevalent in most Westernised democratic nations over the last 30 years. Under discussion are essential questions concerning national identity/ies, competing narratives and the aims of history education. The impact of ‘history wars’ has been felt within both Australia and England, as conservative commentators – including politicians and historians – have raised concerns about the depth and effectiveness of history education and have sought to make significant changes to the history curriculum for schools. This analysis examines the history wars in Australia and England, exploring the view that history education has been in danger and/or crisis and examining the curricular implications of a move toward greater recognition of national narratives. It raises some essential tensions that remain regarding two aspects of history teaching in both nations: (1) historiography and (2) chronological understanding.
Whither the indigenous languages of Brunei Darussalam

L'article examine la situation linguistique changeante au Brunei Darussalam, (sultanat sur la cote nord de Borneo), ou sont parlees au moins huit langues austronesiennes. Il veut montrer la vitalite actuelle des langues indigenes en examinant l'histoire sociolinguistique de la communaute bruneienne et les facteurs environnementaux (historiques, demographiques, economiques, politiques et religieux) qui ont affecte le systeme linguistique du Brunei
Asp299Gly and Thr399Ile genotypes of the TLR4 gene are associated with a reduced prevalence of diabetic neuropathy in patients with type 2 diabetes.

OBJECTIVE To establish whether single nucleotide polymorphisms (Asp299Gly and Thr399Ile) of the toll-like receptor 4 have an association with late diabetic complications. RESEARCH DESIGN AND METHODS The study was conducted in 246 type 1 and 530 type 2 diabetic patients. The alleles of both polymorphisms were detected using PCR and subsequent cleavage by NcoI and HinfI restriction endonucleases. RESULTS No difference was found between type 1 and type 2 diabetic patients in the prevalence of alleles of the Asp299Gly and Thr399Ile polymorphisms. In most cases, the alleles Gly299 and Ile399 occurred in a co-segregatory manner. The prevalence of the Gly299/Ile399 haplotype was 10.6 and 12.1% in type 1 and type 2 diabetic patients, respectively (P = 0.63). No association with diabetic nephropathy or diabetic neuropathy was found in type 1 diabetic patients. In type 2 diabetic patients, however, heterozygote carriers of the Asp299Gly and Thr399Ile genotypes had a significantly reduced prevalence of diabetic neuropathy (odds ratio 0.35 [95% CI 0.19-0.61]; P = 0.0002); no association with diabetic nephropathy was found. CONCLUSIONS Our data indicate that Asp299Gly and Thr399Ile genotypes of the TLR4 gene are associated with reduced prevalence of diabetic neuropathy in type 2, but not in type 1, diabetes. Thus different mechanisms may be involved in the pathophysiology of diabetic neuropathy in type 1 and type 2 diabetes.
Moral Affects, Empathy, and Integrative Self-Knowledge in Iran

In the more individualistic West, guilt promotes and shame interferes with empathic sensitivity. This investigation sought to determine if similar results would appear in the presumably more interdependent cultural context of Iran. Iranian university students (N = 220) responded to guilt and shame scales along with measures of other-oriented empathy and empathic distress. As in the West, guilt predicted greater other-oriented empathy, shame correlated positively with empathic distress, and relationships with integrative self-knowledge, self-esteem, covert narcissism, depression, and anxiety confirmed guilt and other-oriented empathy as adaptive and shame and empathic distress as maladaptive. Integrative self-knowledge mediated shame but not guilt relationships with other measures. In contrast to Western findings, Iranian women did not score higher on shame, and guilt correlated positively with empathic distress. These data confirmed Iranian parallels with the previously reported dynamics of empathy and moral affects in the West, but Iranian differences also pointed toward the need for additional research.
Functional GI disorders: from animal models to drug development

Despite considerable efforts by academic researchers and by the pharmaceutical industry, the development of novel pharmacological treatments for irritable bowel syndrome (IBS) and other functional gastrointestinal (GI) disorders has been slow and disappointing. The traditional approach to identifying and evaluating novel drugs for these symptom-based syndromes has relied on a fairly standard algorithm using animal models, experimental medicine models and clinical trials. In the current article, the empirical basis for this process is reviewed, focusing on the utility of the assessment of visceral hypersensitivity and GI transit, in both animals and humans, as well as the predictive validity of preclinical and clinical models of IBS for identifying successful treatments for IBS symptoms and IBS-related quality of life impairment. A review of published evidence suggests that abdominal pain, defecation-related symptoms (urgency, straining) and psychological factors all contribute to overall symptom severity and to health-related quality of life. Correlations between readouts obtained in preclinical and clinical models and respective symptoms are small, and the ability to predict drug effectiveness for specific as well as for global IBS symptoms is limited. One possible drug development algorithm is proposed which focuses on pharmacological imaging approaches in both preclinical and clinical models, with decreased emphasis on evaluating compounds in symptom-related animal models, and more rapid screening of promising candidate compounds in man.
Human metapneumovirus infection in hospital referred South African children

Human metapneumovirus (hMPV) was first described in Dutch children with acute respiratory symptoms. A prospective analysis of the epidemiology, clinical manifestation, and seroprevalence of hMPV and other respiratory viruses in South African children referred to hospital for upper or lower respiratory tract infection were carried out during a single winter season, by using RT‐PCR, viral culture, and enzyme‐linked immunosorbent assays. In nasopharyngeal aspirates from 137 children, hMPV was detected by RT‐PCR in 8 (5.8%) children (2–43 months of age) as a sole viral pathogen, respiratory syncytial virus (RSV) in 21 (15%), influenza A virus in 18 (13%) and influenza B virus in 20 (15%). Pneumonia was diagnosed in seven children and upper respiratory tract infection in one of the hMPV‐infected children. One hMPV‐infected child was admitted to the intensive care unit in need of mechanical ventilation and one child was infected with human immunodeficiency virus (HIV). No statistically significant differences were found between hMPV, RSV, and influenza virus infected groups with regard to clinical signs and symptoms and chest radiograph findings. The seropositive rate of hMPV specific IgG antibodies was 92% in children aged 24–36 months, the oldest seronegative child in our study was 7 years and 6 months of age. In conclusion, hMPV contributes to upper and lower respiratory tract morbidity in South African children. J. Med. Virol. 73:486–493, 2004. © 2004 Wiley‐Liss, Inc.
The effect of H-polarization on backscattering enhancement for partially convex targets of large sizes in continuous random media

Abstract In our previous work, we have proved that the spatial coherence length (SCL) of the incident waves around the target together with the target configuration play a leading role in the determination of the enhancement in the radar cross-section (ERCS) of a target in a random medium. Owing to the double-passage effect, the ERCS is almost two when the SCL is much smaller or larger than the target size. However, for a SCL comparable with the target size, the ERCS deviates from two, depending on the target parameters and the SCL. The last conclusion was proved only for E-polarization. The polarization of incident waves is one of the key parameters in scattering problems. In this work, we extend our study and investigate the effect of H-polarization on the radar cross-section and the ERCS for large-size targets.
Echo-detected electron paramagnetic resonance spectra of spin-labeled lipids in membrane model systems

The dynamics of spin-labeled lipid chains in the low-temperature phases of dipalmitoyl phosphatidylcholine (DPPC) membranes, with and without equimolar cholesterol, have been investigated by pulsed electron paramagnetic resonance (EPR) spectroscopy. Echo-detected spectra from the two-pulse, primary spin-echo (pulse sequence: π/2-τ-π-τ-echo) are used to detect rapid angular motions, on the time scale of the phase memory time (T 2 M ) that is in the nanosecond regime. Echo-detected spectra from the three-pulse, stimulated spin-echo (pulse sequence: π/2-τ-π/2-T-π/2-τ-echo) are used to detect slow angular motions, on the time scale of the spin-lattice relaxation time (T 1 ) that is in the microsecond regime. Spectra recorded at very low temperature (77 K) are used to correct the two-pulse echo spectra for instantaneous diffusion that arises from dipolar spin-spin interactions between different spin labels. Echo-detected inversion recovery spectra are used to correct the three-pulse echo spectra for intrinsic spin-lattice relaxation and large-scale spectral diffusion induced by nitrogen nuclear spin flips. The dependence of the echo-detected spectral line shapes on the two time delays, r and T, can be simulated adequately by using a simple two-state model to represent the small-amplitude librational motions in the low-temperature membrane phases. The fast librational motion has isotropic character, no singly defined direction of the librational axis, and is segmental in nature, depending on chain position and also on the presence of cholesterol. The slow librational motion is of a more global, cooperative nature, being independent of chain position and cholesterol content.
Increased Migration of Monocytes in Essential Hypertension Is Associated with Increased Transient Receptor Potential Channel Canonical Type 3 Channels

Increased transient receptor potential canonical type 3 (TRPC3) channels have been observed in patients with essential hypertension. In the present study we tested the hypothesis that increased monocyte migration is associated with increased TRPC3 expression. Monocyte migration assay was performed in a microchemotaxis chamber using chemoattractants formylated peptide Met-Leu-Phe (fMLP) and tumor necrosis factor-α (TNF-α). Proteins were identified by immunoblotting and quantitative in-cell Western assay. The effects of TRP channel-inhibitor 2–aminoethoxydiphenylborane (2-APB) and small interfering RNA knockdown of TRPC3 were investigated. We observed an increased fMLP-induced migration of monocytes from hypertensive patients compared with normotensive control subjects (246±14% vs 151±10%). The TNF-α-induced migration of monocytes in patients with essential hypertension was also significantly increased compared to normotensive control subjects (221±20% vs 138±18%). In the presence of 2-APB or after siRNA knockdown of TRPC3 the fMLP-induced monocyte migration was significantly blocked. The fMLP-induced changes of cytosolic calcium were significantly increased in monocytes from hypertensive patients compared to normotensive control subjects. The fMLP-induced monocyte migration was significantly reduced in the presence of inhibitors of tyrosine kinase and phosphoinositide 3-kinase. We conclude that increased monocyte migration in patients with essential hypertension is associated with increased TRPC3 channels.