Miracle-dz/UniFAR-FTUs huggingface dataset:
Verb impairment in aphasia: A priming study of body-part overlap

Background: Verb production impairments are well documented in aphasia, especially in non-fluent aphasias with lesions of the left frontal lobe. Evidence is inconclusive about whether the impaired verb production is accompanied by inefficient processing and comprehension of verbs. It is unknown if specific semantic features of verbs, such as knowledge of the effector (body-part used to implement the action), are automatically activated by aphasic individuals during verb processing. This question is especially relevant given the growing evidence that unimpaired speakers mentally simulate the action portrayed by a verb, and action simulation is an inherent part of language comprehension (embodied action semantics). There is additional evidence that reading or listening to verbs depicting hand, mouth, or leg actions activates frontal motor areas associated with implementing hand, mouth, and leg actions respectively in unimpaired individuals (semantic somatotopy). Aims: This study examined on-line verb processing in nonfluent aphasic participants who are impaired in production of verbs. We investigated (1) whether somatotopic (body-part) information is automatically accessed when processing verbs, (2) how the time course of this activation influences processing of other somatotopically related verbs, and (3) whether somatotopic information that is devoid of action context (as in line drawings of body-parts) can affect downstream verb processing. Methods & Procedures: A visual-visual lexical priming paradigm was used. In Experiments 1 and 2, the prime–target verb pairs were somatotopically congruent, incongruent, or neutral nonword (licking–kissing; licking–clapping, xxxx–clapping respectively), and the stimulus onset asynchrony (SOA) was short or long. Instead of verbs, the primes in Experiment 3 were line drawings of congruent or incongruent body-parts. Six nonfluent agrammatic aphasic individuals with verb retrieval difficulties participated in the study. Outcomes & Results: Aphasic participants were highly accurate in their responses. Lexical decision speed was influenced by the preceding primes in a specific pattern: somatotopically congruent primes caused a delay (interference) in response times, and this diminished with longer SOA. Incongruent primes had no effect on response times. Picture primes caused a general delay in lexical decision speed, but this was not a somatotopically specific effect. This pattern of results is identical to that observed with unimpaired participants. Conclusions: This group of verb-impaired aphasic individuals was able to automatically (and rapidly) activate somatotopic features of verbs, showing little evidence of impaired lexical-semantic representations. Hence verb processing and verb naming were found to dissociate. In addition, this study extends our understanding of language processing by showing that actions are simulated by the human brain, even when verbs are encountered as de-contextualised single words. Further, somatotopic information is necessary, but not sufficient, for action simulation.
The basic principles of medicine in the primitive mind.

THE DESIRE to maintain, reinforce or restore health, has everywhere followed initially two distinct trends-that of instinctive or empirical medicine, and that of magic or sacerdotal medicine. The fusion of these two accidental at first, then systematic and by intent-had as a happy and paradoxical consequence the progressive laicization of the profession; a preliminary condition necessary to its development. Instinctive and empirical medicine has had to start with a very limited field of action-that of morbid conditions, the cause or the agent of which is evident and directly recognizable. This means that it applied itself mainly to superficial traumatic complaints. Long before the appearance of Homo Sapiens, the instinct of the-animals had taught them how to immobilize a broken leg; to lick a wound; to get rid of a thorn; or even to absorb a purgative herb. Pliny considers that animal medicine has directly inspired that of man. Then man put to the service of his own instinct the resources of an elementary logic. Later, medical empirical knowledge was born from occasional and repeated findings, and from remembering and recording certain happy results fortuitously obtained. At this stage man learned how to summarily reduce, and later how to immobilize a fracture or a luxation; how to extract an accessible foreign body, manifestly causing his pain; and how to resort to baths and diet. The relief brought about by the spontaneous opening of an abscess prompted him to incise, with a stone splinter or a bronze blade, the superficial collections of pus. Aware of the fact that repeated ingestion of the same noxious substance regularly brings about the same disorders, he doubtless and precociously had the idea of evacuating it as soon as possible by using vegetable drugs, ofwhich he had noticed the emetic or purgative effects. Through the following ages, intuitive and intelligent empiricism has been at the origin of countless therapeutic discoveries. Fortuitous comparisons probably brought to light, in the East or in Byzantium, the antigouty virtues of colchicum; and thanks to the same mental process, the American Indian tribes used for the first time the febrifuge action ofcinchona bark and the antidiarrhoeic effect ofipecacuanha. For having at all times practised deep-sea fishing, the natives of Polynesia spontaneously conceived artificial breathing in case of drowning. Many other similar examples could indeed be quoted. Medical empiricism has thus been the earliest precursor of observation, and later of experimental medicine. It seems to have existed in the remotest times, and one *A lcture given at the Welcome Historical Medical Library on 12 July 1966. The author is highly indebted to Mr. and Mrs. James Black for their help in the translation.
Source apportionment of PM10 and PM2.5 in five Chilean cities using factor analysis.

Chile is a fast-growing country with important industrial activities near urban areas. In this study, the mass and elemental concentrations of PM10 and PM2.5 were measured in five major Chilean urban areas. Samples of particles with diameter less than 10 microm (PM10) and 2.5 microm (PM2.5) were collected in 1998 in Iquique (northern Chile), Valparaiso, Viña del Mar, Rancagua (central Chile), and Temuco (southern Chile). Both PM10 and PM2.5 annual mean concentrations (PM10: 56.9-77.6 microg/m3; PM2.5: 22.4-42.6 microg/m3) were significantly higher than the corresponding European Union (EU) and U.S. Environmental Protection Agency (EPA) air quality standards. Moreover, the 24-hr PM10 and PM2.5 U.S. standards were exceeded infrequently for some of the cities (Rancagua and Valparaiso). Elements ranging from Mg to Pb were detected in the aerosol samples using X-ray fluorescence (XRF). For each of the five cities, factor analysis (FA) was applied to identify and quantify the sources of PM10 and PM2.5. The agreement between calculated and measured mass and elemental concentrations was excellent in most of the cities. Both natural and anthropogenic sources were resolved for all five cities. Soil and sea were the most important contributors to coarse particles (PM10-PM2.5), whereas their contributions to PM2.5 were negligible. Emissions from Cu smelters and oil refineries (and/or diesel combustion) were identified as important sources of PM2.5, particularly in the industrial cities of Rancagua, Valparaiso, and Viña del Mar. Finally, motor vehicles and wood burning were significant sources of both PM2.5 and PM10 in most of the cities (wood burning was not identified in Iquique).
Arginase Inhibition Prevents Inflammation and Remodeling in a Guinea Pig Model of Chronic Obstructive Pulmonary Disease

Airway inflammation and remodeling are major features of chronic obstructive pulmonary disease (COPD), whereas pulmonary hypertension is a common comorbidity associated with a poor disease prognosis. Recent studies in animal models have indicated that increased arginase activity contributes to features of asthma, including allergen-induced airway eosinophilia and mucus hypersecretion. Although cigarette smoke and lipopolysaccharide (LPS), major risk factors for COPD, may increase arginase expression, the role of arginase in COPD is unknown. This study aimed to investigate the role of arginase in pulmonary inflammation and remodeling using an animal model of COPD. Guinea pigs were instilled intranasally with LPS or saline twice weekly for 12 weeks and pretreated by inhalation of the arginase inhibitor 2(S)-amino-6-boronohexanoic acid (ABH) or vehicle. Repeated LPS exposure increased lung arginase activity, resulting in increased l-ornithine/l-arginine and l-ornithine/l-citrulline ratios. Both ratios were reversed by ABH. ABH inhibited the LPS-induced increases in pulmonary IL-8, neutrophils, and goblet cells as well as airway fibrosis. Remarkably, LPS-induced right ventricular hypertrophy, indicative of pulmonary hypertension, was prevented by ABH. Strong correlations were found between arginase activity and inflammation, airway remodeling, and right ventricular hypertrophy. Increased arginase activity contributes to pulmonary inflammation, airway remodeling, and right ventricular hypertrophy in a guinea pig model of COPD, indicating therapeutic potential for arginase inhibitors in this disease.
Going to College!

One afternoon we were on our way to meet students at the Physical Education Center at the local college. As we approached campus. we saw a group of students hanging out and laughing. Then we saw a familiar face. Bryan. in the very center of the circle. Certainly nothing unusual about that, to see college students hanging out having fun with their friends between classes. Yet Bryan is a student with severe disabilities; and before the advent of Public Law 94-142. he would not even have been able to attend his regular public school. Now this type of interaction takes place daily for Bryan and six other high school students with moderate and severe disabilities from his school district; they have each become a recognized part of college life on a vibrant campus located in their own community. This article depicts the efforts that the Jessamine County, Kentucky. Public Schools, community members, special education staff and administrators. students, and parents made to develop a program that would meet Bryan's-and other students'-needs in more age-
Growth and growth intentions: a meta-analysis of existing evidence

This white paper summarises what we know about the connection between entrepreneurs’ growth intentions and realised enterprise growth. It addresses the following questions: How strong is the association between entrepreneurial growth intentions and subsequent performance? What affects entrepreneurial growth intentions at the individual level and national level, and how big are these effects? What can be done to raise entrepreneurial growth intentions in the UK? What further research needs to be done in this area?
CD8 Memory Cells Develop Unique DNA Repair Mechanisms Favoring Productive Division

Immune responses are efficient because the rare antigen-specific naïve cells are able to proliferate extensively and accumulate upon antigen stimulation. Moreover, differentiation into memory cells actually increases T cell accumulation, indicating improved productive division in secondary immune responses. These properties raise an important paradox: how T cells may survive the DNA lesions necessarily induced during their extensive division without undergoing transformation. We here present the first data addressing the DNA damage responses (DDRs) of CD8 T cells in vivo during exponential expansion in primary and secondary responses in mice. We show that during exponential division CD8 T cells engage unique DDRs, which are not present in other exponentially dividing cells, in T lymphocytes after UV or X irradiation or in non-metastatic tumor cells. While in other cell types a single DDR pathway is affected, all DDR pathways and cell cycle checkpoints are affected in dividing CD8 T cells. All DDR pathways collapse in secondary responses in the absence of CD4 help. CD8 T cells are driven to compulsive suicidal divisions preventing the propagation of DNA lesions. In contrast, in the presence of CD4 help all the DDR pathways are up regulated, resembling those present in metastatic tumors. However, this up regulation is present only during the expansion phase; i.e., their dependence on antigen stimulation prevents CD8 transformation. These results explain how CD8 T cells maintain genome integrity in spite of their extensive division, and highlight the fundamental role of DDRs in the efficiency of CD8 immune responses.
Distribution and spread of pyrethroid and DDT resistance among the Anopheles gambiae complex in Tanzania

The development of insecticide resistance is a threat to the control of malaria in Africa. We report the findings of a national survey carried out in Tanzania in 2011 to monitor the susceptibility of malaria vectors to pyrethroid, organophosphate, carbamate and DDT insecticides, and compare these findings with those identified in 2004 and 2010. Standard World Health Organization (WHO) methods were used to detect knock‐down and mortality rates in wild female Anopheles gambiae s.l. (Diptera: Culicidae) collected from 14 sentinel districts. Diagnostic doses of the pyrethroids deltamethrin, lambdacyhalothrin and permethrin, the carbamate propoxur, the organophosphate fenitrothion and the organochlorine DDT were used. Anopheles gambiae s.l. was resistant to permethrin in Muleba, where a mortality rate of 11% [95% confidence interval (CI) 6–19%] was recorded, Muheza (mortality rate of 75%, 95% CI 66–83%), Moshi and Arumeru (mortality rates of 74% in both). Similarly, resistance was reported to lambdacyhalothrin in Muleba, Muheza, Moshi and Arumeru (mortality rates of 31–82%), and to deltamethrin in Muleba, Moshi and Muheza (mortality rates of 28–75%). Resistance to DDT was reported in Muleba. No resistance to the carbamate propoxur or the organophosphate fenitrothion was observed. Anopheles gambiae s.l. is becoming resistant to pyrethoids and DDT in several parts of Tanzania. This has coincided with the scaling up of vector control measures. Resistance may impair the effectiveness of these interventions and therefore demands close monitoring and the adoption of a resistance management strategy.
Evaluation of Acceptance of Nursing Information System in a German and American Hospital

Nursing Information Systems (NIS) are not well-adopted and accepted in Germany. The evaluation of a NIS deployment in a German University Hospital supports this assumption. A second side study in the US should point out the differences regarding the technical and organizational differences. We use a questionnaire including standardized instruments like the Unified Theory of Acceptance (UTAUT). Results indicated that nurses in Germany compared to in the US do not use nursing process documentation to the same extent. The main reasons behind the low usage in comparison with the US are deficits in ease-of-use, system performance and the high expenditure of time and paper work for charting nursing plans.
Feedforward and feedback in speech perception: Revisiting analysis by synthesis

We revisit the analysis by synthesis (A×S) approach to speech recognition. In the late 1950s and 1960s, Stevens and Halle proposed a model of spoken word recognition in which candidate word representations were synthesised from brief cues in the auditory signal and analysed against the input signal in tightly linked bottom-up/top-down fashion. While this approach failed to garner much support at the time, recent years have brought a surge of interest in Bayesian approaches to perception, and the idea of A×S has consequently gained attention, particularly in the domain of visual perception. We review the model and illustrate some data from speech perception that are well-accounted for in the context of such an architecture. We focus on prediction in speech perception, an operation at the centre of the A×S algorithm. The data reviewed here and the current possibilities to study online measures of speech processing using cognitive neuroscience methods, in our view, add to a provocative series of arguments why A×S should be reconsidered as a contender in speech recognition research, complementing currently more dominant models.
Position-Specific Analysis and Prediction of Protein Pupylation Sites Based on Multiple Features

Pupylation is one of the most important posttranslational modifications of proteins; accurate identification of pupylation sites will facilitate the understanding of the molecular mechanism of pupylation. Besides the conventional experimental approaches, computational prediction of pupylation sites is much desirable for their convenience and fast speed. In this study, we developed a novel predictor to predict the pupylation sites. First, the maximum relevance minimum redundancy (mRMR) and incremental feature selection methods were made on five kinds of features to select the optimal feature set. Then the prediction model was built based on the optimal feature set with the assistant of the support vector machine algorithm. As a result, the overall jackknife success rate by the new predictor on a newly constructed benchmark dataset was 0.764, and the Mathews correlation coefficient was 0.522, indicating a good prediction. Feature analysis showed that all features types contributed to the prediction of protein pupylation sites. Further site-specific features analysis revealed that the features of sites surrounding the central lysine contributed more to the determination of pupylation sites than the other sites.
Kinship between parents reduces offspring fitness in a natural population of Rhododendron brachycarpum.

BACKGROUND AND AIMS A reduction in offspring fitness resulting from mating between neighbours is interpreted as biparental inbreeding depression. However, little is known about the relationship between the parents' genetic relatedness and biparental inbreeding depression in their progeny in natural populations. This study assesses the effect of kinship between parents on the fitness of their progeny and the extent of spatial genetic structure in a natural population of Rhododendron brachycarpum. METHODS Kinship coefficients between 11,858 pairs of plants among a natural population of 154 R. brachycarpum plants were estimated a priori using six microsatellite markers. Plants were genotyped, and pairs were selected from among 60 plants to vary the kinship from full-sib to unrelated. After a hand-pollination experiment among the 60 plants, offspring fitness was measured at the stages of seed maturation (i.e. ripening) under natural conditions, and seed germination and seedling survival under greenhouse conditions. In addition, spatial autocorrelation was used to assess the population's genetic structure. KEY RESULTS Offspring fitness decreased significantly with increasing kinship between parents. However, the magnitude and timing of this effect differed among the life-cycle stages. Measures of inbreeding depression were 0.891 at seed maturation, 0.122 (but not significant) at seed germination and 0.506 at seedling survival. The local population spatial structure was significant, and the physical distance between parents mediated the level of inbreeding between them. CONCLUSIONS The level of inbreeding between individuals determines offspring fitness in R. brachycarpum, especially during seed maturation. Genetic relatedness between parents caused inbreeding depression in their progeny. Therefore, biparental inbreeding contributes little to reproduction and instead acts as a selection force that promotes outcrossing, as offspring of more distant (less related) parents survive better.
Why Is That Relevant? Collecting Annotator Rationales for Relevance Judgments

When collecting subjective human ratings of items, it can be difficult to measure and enforce data quality due to task subjectivity and lack of insight into how judges’ arrive at each rating decision. To address this, we propose requiring judges to provide a specific type of rationale underlying each rating decision. We evaluate this approach in the domain of Information Retrieval, where human judges rate the relevance of Webpages to search queries. Cost-benefit analysis over 10,000 judgments collected on Mechanical Turk suggests a win-win: experienced crowd workers provide rationales with almost no increase in task completion time while providing a multitude of further benefits, including more reliable judgments and greater transparency for evaluating both human raters and their judgments. Further benefits include reduced need for expert gold, the opportunity for dual-supervision from ratings and rationales, and added value from the rationales themselves.
Physiological Trade-Offs Along a Fast-Slow Lifestyle Continuum in Fishes: What Do They Tell Us about Resistance and Resilience to Hypoxia?

It has recently been suggested that general rules of change in ecological communities might be found through the development of functional relationships between species traits and performance. The physiological, behavioural and life-history traits of fishes are often organised along a fast-slow lifestyle continuum (FSLC). With respect to resistance (capacity for population to resist change) and resilience (capacity for population to recover from change) to environmental hypoxia, the literature suggests that traits enhancing resilience may come at the expense of traits promoting resistance to hypoxia; a trade-off may exist. Here I test whether three fishes occupying different positions along the FSLC trade-off resistance and resilience to environmental hypoxia. Static respirometry experiments were used to determine resistance, as measured by critical oxygen tension (Pcrit), and capacity for (RC) and magnitude of metabolic reduction (RM). Swimming respirometry experiments were used to determine aspects of resilience: critical (U crit) and optimal swimming speed (U opt), and optimal cost of transport (COTopt). Results pertaining to metabolic reduction suggest a resistance gradient across species described by the inequality Melanotaenia fluviatilis (fast lifestyle) < Hypseleotris sp. (intermediate lifestyle) < Mogurnda adspersa (slow lifestyle). The Ucrit and COTopt data suggest a resilience gradient described by the reverse inequality, and so the experiments generally indicate that three fishes occupying different positions on the FSLC trade-off resistance and resilience to hypoxia. However, the scope of inferences that can be drawn from an individual study is narrow, and so steps towards general, trait-based rules of fish community change along environmental gradients are discussed.