Miracle-dz/UniFAR-FTUs huggingface dataset:
Proactive career self-management: exploring links among psychosocial career attributes and adaptability resources

The study explored whether the positive links between individuals’ psychosocial career attributes and career adaptability resources empirically represent the characteristics associated with proactive career self-management behaviour. A cross-sectional convenience sample of Black and White (N = 248) working adults participated in the study. The redundancy analysis of the canonical correlation analysis indicated positive links between the career attributes of behavioural adaptability, career directedness, self-esteem, self/other skills, social connectivity, and career purpose, and the four career adaptability resources of career concern, career control, career curiosity, and career confidence. The common synthetic themes that emerged from the positive associations described the characteristics of proactive career self-management behaviour, including (1) self-efficacious adaptive goal-directed behaviour, (2) proactive psychosocial career engagement behaviour, and (3) career resilience. The three dimensions offer considerations for practitioners involved in career development and counselling discussions with employees who need to develop personal agency in their career development and management.
In search of candidate genes critically expressed in the human endometrium during the window of implantation.

BACKGROUND In this prospective randomized blinded clinical trial, we examined gene expression profiles of the human endometrium during the early and mid-luteal phases of the natural cycle. METHODS An endometrial biopsy was performed on day 16 (LH +3) or on day 21 (LH +8), followed by RNA extraction and microarray analysis using an Affymetrix HG-U95A microchip. Data analysis was carried out using pairwise multiple group comparison with the significance analysis of microarrays (SAM) software. RESULTS With a false discovery rate of 0, the analysis revealed that 107 genes were significantly and differently expressed (> or =2-fold) during the early versus the mid-luteal phase of the cycle. Forty-five of these genes have not been previously linked to endometrial receptivity. Validation of the microarray data was accomplished using semiquantitative RT-PCR. We demonstrated the presence of estrogen and progesterone response elements (ERE and PRE) by analysis of the 5'-flanking regions of a subset of differentially regulated genes. CONCLUSIONS Using a strict bioinformatics approach of microarray data, we demonstrated significant changes in candidate genes during the transition of the early to the mid-luteal phase of the human endometrium that may have functional significance for the opening and maintenance of the window of implantation.
Potential Savings of Harmonising Hospital and Community Formularies for Chronic Disease Medications Initiated in Hospital

Background Hospitals in Canada manage their formularies independently, yet many inpatients are discharged on medications which will be purchased through publicly-funded programs. We sought to determine how much public money could be saved on chronic medications if hospitals promoted the initiation of agents with the lowest outpatient formulary prices. Methods We used administrative databases for the province of Ontario to identify patients initiated on a proton pump inhibitor (PPI), angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) following hospital admission from April 1st 2008-March 31st 2009. We assessed the cost to the Ontario Drug Benefit Program (ODB) over the year following initiation and determined the cost savings if prescriptions were substituted with the least expensive agent in each class. Results The cost for filling all PPI, ACE inhibitor and ARB prescriptions was $ 2.48 million, $968 thousand and $325 thousand respectively. Substituting the least expensive agent could have saved $1.16 million (47%) for PPIs, $162 thousand (17%) for ACE inhibitors and $14 thousand (4%) for ARBs over the year following discharge. Interpretation In a setting where outpatient prescriptions are publicly funded, harmonising outpatient formularies with inpatient therapeutic substitution resulted in modest cost savings and may be one way to control rising pharmaceutical costs.
Newspaper Presentations of Homosexuality across Nations: Examining Differences by Religion, Economic Development, and Democracy

A lot of research attention has been devoted to understanding cross-national differences in attitudes about homosexuality. A key finding has been that richer, more democratic, and less religious nations are more supportive. However, aside from establishing these relationships, we know little about how public discourse about homosexuality differs across nations. To better understand how public discussions about sexual minorities are framed, this multimethods’ study examines over 800 newspaper articles from Muslim and Protestant-majority nations. Although there are no differences in the extent to which Muslim and Protestant nations discuss homosexuality in the context of religion, Muslim nations are more likely to frame homosexuality as a moral issue and use government claimsmakers. Very poor countries are also more likely to associate homosexuality with morality. Finally, more democratic nations are more likely to discuss homosexuality in the context of rights and include social movement leaders as claimsmakers.
Modeling perceptual similarity as analogy resolves the paradox of difference detection

There is a paradoxical dissociation between recognizing that two stimuli are different and recognizing how they are different. We show that this dissociation can be captured by modeling perceptual similarity as a species of analogical processes. Using SME to model comparison, we show that the dissociation arises naturally from different stages in the analogical mapping process. Rather than relying on hand-coded input representations, our model uses an automatic, incremental encoding process to generate representations from the same stimuli as given to human participants.
Towards a Theoretical Explanation of Time-Varying Trading

Investors do not continuously modify their portfolio allocations with the arrival of new information. Rather, extended periods of inertia are alternated with brief moments of action where asset allocations are updated according to the current state of the economy. We explain this pattern of behavior by developing a theoretical framework that introduces information costs into a continuous-time model of asset allocation with time-varying investment opportunities. Our model explains why individuals’ attention to their investment portfolio is high when the expected gains from investing in the stock market are large, such as during recessions. It also explains why investors’ portfolio adjustments are lumpy in nature. The model implies a weak and time-varying co-variation between consumption growth and equity returns and so helps explain why the equity premium can be high despite the low correlation between stock returns and consumption changes. The microeconomic implications of our analysis are tested empirically against competing models of asset allocation using duration models estimated on Odean (1999)’s brokerage account data and through panel data estimates based on the PSID. Our macroeconomic predictions are supported by tests based on both high and low frequency economic and nancial time-series.
Effects of phase noise on performance of OFDM systems using an ICI cancellation scheme

This paper investigates the effects of phase noise on the performance of orthogonal frequency division multiplexing (OFDM) systems using an intercarrier interference (ICI) cancellation scheme. In this case, the common phase error (CPE) and ICI caused by phase noise depend on the overall spectrum of each weighted group of subcarriers rather than on the spectrum of each individual subcarrier. This means that the system performance can be improved by filtering the phase noise to fit a particular spectrum. It is shown that the ICI cancellation scheme can significantly improve the bit error rate (BER) performance in the presence of phase noise.
Retrotransposon-Induced Heterochromatin Spreading in the Mouse Revealed by Insertional Polymorphisms

The “arms race” relationship between transposable elements (TEs) and their host has promoted a series of epigenetic silencing mechanisms directed against TEs. Retrotransposons, a class of TEs, are often located in repressed regions and are thought to induce heterochromatin formation and spreading. However, direct evidence for TE–induced local heterochromatin in mammals is surprisingly scarce. To examine this phenomenon, we chose two mouse embryonic stem (ES) cell lines that possess insertionally polymorphic retrotransposons (IAP, ETn/MusD, and LINE elements) at specific loci in one cell line but not the other. Employing ChIP-seq data for these cell lines, we show that IAP elements robustly induce H3K9me3 and H4K20me3 marks in flanking genomic DNA. In contrast, such heterochromatin is not induced by LINE copies and only by a minority of polymorphic ETn/MusD copies. DNA methylation is independent of the presence of IAP copies, since it is present in flanking regions of both full and empty sites. Finally, such spreading into genes appears to be rare, since the transcriptional start sites of very few genes are less than one Kb from an IAP. However, the B3galtl gene is subject to transcriptional silencing via IAP-induced heterochromatin. Hence, although rare, IAP-induced local heterochromatin spreading into nearby genes may influence expression and, in turn, host fitness.
Culture, Contraception, and Colorblindess: Youth Sexual Health Promotion as a Gendered Racial Project

Feminist scholars have identified how race and gender discourses influence the creation and implementation of school-based sexual health education and the provision of health care, yet there are few studies that examine how race and gender work in sexual health promotion as it occurs through community-based public health efforts. Drawing on three years of ethnographic research in a low-income Puerto Rican community, this article demonstrates how a gendered racial project of essentializing Latinx culture surrounding young women’s sexuality and reproduction works to both obscure and reinforce race and racism in sexual health promotion. Professional stakeholders mobilize culture as an explanation for high birth rates among young Latinas in the city and reproduce a “Latino culture narrative” in which Latina gender and sexuality is understood as deterministic and homogenous. Simultaneously, an ideology of colorblindness enables the uncritical promotion of long-acting reversible contraception and obscures the history of reproductive oppression experienced by women of color. I consider how colorblindness and culture narratives allow stakeholders to abdicate responsibility for gendered racial inequality and conclude by advocating for the incorporation of racial and reproductive justice frameworks in sexual health promotion.
Evaluation of classification models for language processing

Naïve Bayes is a commonly used algorithm in text categorization because of its easy implementation and low complexity. Naïve Bayes has mainly two event models used for text categorization which are multivariate Bernoulli and multinomial models. A very large number of studies choose multinomial model and Laplace smoothing just based on the assumption that it performs better than multivariate model under almost any conditions. This study aims to shed some light into this widely adopted assumption by analyzing Naïve Bayes event models and smoothing methods from a different perspective. To clarify the difference between events models of Naïve Bayes, their classification performance are compared on different languages - English and Turkish - datasets. Results of our extensive experiments demonstrate that superior performance of multinomial model does not observed all the time. On the other hand, multivariate Bernoulli model can perform well when combined with an appropriate smoothing method under different training data size conditions.
COMPARING LEARNERS ’ AFFECT WHILE USING AN INTELLIGENT TUTOR AND AN EDUCATIONAL GAME

We compare the affect associated with students learning from an intelligent tutoring system, Aplusix, and a game, Math Blaster 9-12, covering very similar mathematical content. Quantitative field observations of student affect were conducted in classrooms in private schools in the Philippines. Students experienced large amounts of positive affect in both environments. It has been hypothesized that educational games will lead to better affect than other forms of educational software, but it was found that students experienced more positive affect (specifically, engaged concentration) and less negative affect (specifically, boredom) in the intelligent tutor than in the game, though there was a trend towards more delight within the game. These results suggest that intelligent tutors may be more affectively successful than had previously been realized. An alternate possible implication is that games’ motivational benefits are not solely in terms of moment-tomoment affective experience. At the same time, the differential affective benefits of the two genres of educational software suggests that some blend of the two types of learning environments may be more engaging than any existing educational software.
Effects of Thyroid Hormone Analogue and a Leukotrienes Pathway-Blocker on Reperfusion Injury Attenuation after Heart Transplantation

Background. Global myocardial ischemia reperfusion injury after heart transplantation is believed to impair graft function and aggravate both acute and chronic rejection episodes. Objectives. To assess the possible protective potential of MK-886 and 3,5-diiodothyropropionic acid DITPA against global myocardial ischemia reperfusion injury after heart transplantation. Materials and Methods. Adult albino rats were randomized into 6 groups as follows: group I sham group; group II, control group; groups III and IV, control vehicles (1,2); group V, MK-886 treated group. Donor rats received MK-886 30 min before transplantation, and the same dose was repeated for recipients upon reperfusion; in group VI, DITPA treated group, donors and recipients rats were pretreated with DITPA for 7 days before transplantation. Results. Both MK-886 and DITPA significantly counteract the increase in the levels of cardiac TNF-α, IL-1β, and ICAM-1 and plasma level of cTnI (P < 0.05). Morphologic analysis showed that both MK-886 and DITPA markedly improved (P < 0.05) the severity of cardiac injury in the heterotopically transplanted rats. Conclusions. The results of our study reveal that both MK-886 and DITPA may ameliorate global myocardial ischemia reperfusion injury after heart transplantation via interfering with inflammatory pathway.
A ‘real’ fantasy: hybridity, Korean drama, and pop cosmopolitans

This study examines the complex, multidirectional process of media transnationalization and online fandom within the new media environment, focusing on the transnational media flows from the East to the West. Based on an online ethnography examining the fan culture surrounding Korean television drama (K-drama) in the West, this study explores the appeal of K-drama to Western fans and its impact on fans’ identities and worldviews. The analysis suggests that scholars should take a closer look at transnational media fandom as a key site for identity creation and embrace of pop cosmopolitanism.
The Performance of Pre‐Founding Entrepreneurial Teams: The Importance of Learning and Leadership

Entrepreneurial teams often struggle with simultaneous task and team challenges at an early stage of new venture creation. The way in which teams shape their teamwork is key in leveraging performance in the pre-founding phase. Learning should help the team in establishing good teamwork and in expanding its members entrepreneurial capabilities. Leadership is needed to facilitate and guide this learning. Accordingly, we investigated learning and leadership as facilitators of performance in the pre-founding phase. Specifically, we examined team reflexivity as a collective internal learning process and boundary spanning behaviour as an externally directed individual activity, operating at different levels in fostering team and individual performance. Charismatic team leadership was examined as a catalyst of learning, shaping team and individual performance ultimately. The multilevel mediation model was tested based on data from 196 members of 58 teams of a venture creation programme. Team reflexivity predicted team and individual performance. Boundary spanning behaviour was not related to performance. As hypothesised, charismatic team leadership predicted team and individual performance, both mediated by team reflexivity. This research highlights the relevance of team learning in pre-founding teams and emphasises leadership in shaping learning and moving new ventures forward.
Temporal abundance of Aedes aegypti in Manaus, Brazil, measured by two trap types for adult mosquitoes

A longitudinal study was conducted in Manaus, Brazil, to monitor changes of adult Aedes aegypti (L.) abundance. The objectives were to compare mosquito collections of two trap types, to characterise temporal changes of the mosquito population, to investigate the influence of meteorological variables on mosquito collections and to analyse the association between mosquito collections and dengue incidence. Mosquito monitoring was performed fortnightly using MosquiTRAPs (MQT) and BG-Sentinel (BGS) traps between December 2008-June 2010. The two traps revealed opposing temporal infestation patterns, with highest mosquito collections of MQTs during the dry season and highest collections of BGS during the rainy seasons. Several meteorological variables were significant predictors of mosquito collections in the BGS. The best predictor was the relative humidity, lagged two weeks (in a positive relationship). For MQT, only the number of rainy days in the previous week was significant (in a negative relationship). The correlation between monthly dengue incidence and mosquito abundance in BGS and MQT was moderately positive and negative, respectively. Catches of BGS traps reflected better the dynamic of dengue incidence. The findings help to understand the effects of meteorological variables on mosquito infestation indices of two different traps for adult dengue vectors in Manaus.
The Intracellular Delivery of a Recombinant Peptide Derived from the Acidic Domain of PIAS3 Inhibits STAT3 Transactivation and Induces Tumor Cell Death

Signaling components, which confer an “addiction” phenotype on cancer cells, represent promising drug targets. The transcription factor signal transducers and activators of transcription 3 (STAT3) is constitutively activated in many different types of tumor cells and its activity is indispensible in a large fraction. We found that the expression of the endogenous inhibitor of STAT3, protein inhibitor of activated STAT3 (PIAS3), positively correlates with STAT3 activation in normal cells. This suggests that PIAS3 controls the extent and the duration of STAT3 activity in normal cells and thus prevents its oncogenic function. In cancer cells, however, the expression of PIAS3 is posttranscriptionally suppressed, possibly enhancing the oncogenic effects of activated STAT3. We delimited the interacting domains of STAT3 and PIAS3 and identified a short fragment of the COOH-terminal acidic region of PIAS3, which binds strongly to the coiled-coil domain of STAT3. This PIAS3 fragment was used to derive the recombinant STAT3-specific inhibitor rPP-C8. The addition of a protein transduction domain allowed the efficient internalization of rPP-C8 into cancer cells. This resulted in the suppression of STAT3 target gene expression, in the inhibition of migration and proliferation, and in the induction of apoptosis at low concentrations [half maximal effective concentration (EC50), <3 μmol/L]. rPP-C8 did not affect normal fibroblasts and represents an interesting lead for the development of novel cancer drugs targeting the coiled-coil domain of STAT3. Mol Cancer Res; 8(4); 539–53. ©2010 AACR.
The Indeterminacy/Attestation Model of Metathesis

This paper addresses three key observations relating to crosslinguistic patterns of metathesis. First, the order of sounds resulting from metathesis can differ from language to language such that a similar combination of sounds can be realized in one order in one language, but in the reverse order in another language. Second, for some sound combinations, only one order is commonly attested as the result of metathesis, while for other combinations, either order can be observed. Third, the acoustic/auditory cues to the identification of the sequence resulting from metathesis are often better than those of the expected, yet nonoccurring, order. These patterns receive a straightforward explanation when we consider the phonetic nature of the sounds involved as well as the speaker/hearer's knowledge of native sound patterns and their frequency of occurrence. Neither factor alone is sufficient to provide a predictive account of metathesis. This study shows, however, that by taking into account both factors, we are able to understand why certain sound combinations tend to undergo metathesis, why others are common results of metathesis, why patterns of metathesis differ across languages, and, importantly, why metathesis occurs in the first place.
C‐LOD: Context‐aware Material Level‐of‐Detail applied to Mobile Graphics

Attention‐based Level‐Of–Detail (LOD) managers downgrade the quality of areas that are expected to go unnoticed by an observer to economize on computational resources. The perceptibility of lowered visual fidelity is determined by the accuracy of the attention model that assigns quality levels. Most previous attention based LOD managers do not take into account saliency provoked by context, failing to provide consistently accurate attention predictions. In this work, we extend a recent high level saliency model with four additional components yielding more accurate predictions: an object‐intrinsic factor accounting for canonical form of objects, an object‐context factor for contextual isolation of objects, a feature uniqueness term that accounts for the number of salient features in an image, and a temporal context that generates recurring fixations for objects inconsistent with the context. We conduct a perceptual experiment to acquire the weighting factors to initialize our model. We design C‐LOD, a LOD manager that maintains a constant frame rate on mobile devices by dynamically re‐adjusting material quality on secondary visual features of non‐attended objects. In a proof of concept study we establish that by incorporating C‐LOD, complex effects such as parallax occlusion mapping usually omitted in mobile devices can now be employed, without overloading GPU capability and, at the same time, conserving battery power.
Is oversensitive spectrum sensing the door opener for initial cognitive radio deployments?

It is often stated that sensing based opportunistic spectrum sharing requires several tens of sensors or infrastructure support to achieve a reliable Primary User (PU) detection. This is considered a significant entry barrier for opportunistic, sensing based Cognitive Radio (CR) networks. In this paper we suggest an approach making deployment of small configurations of such networks feasible without the need of infrastructure sensing support and discuss the resulting strategy of gradual deployment of such CR networks.