Miracle-dz/UniFAR-FTUs huggingface dataset:
Impact of race on intraoperative parathyroid hormone kinetics: an analysis of 910 patients undergoing parathyroidectomy for primary hyperparathyroidism.

HYPOTHESIS African American patients exhibit different intraoperative parathyroid hormone (IOPTH) profiles than non-African American patients. DESIGN Retrospective review. SETTING University medical center. PATIENTS Nine hundred ten patients who underwent parathyroidectomy for primary hyperparathyroidism between July 2005 and August 2010. INTERVENTIONS All patients underwent preoperative imaging with ultrasonography and sestamibi; operative exploration; and IOPTH measurement at 2 points preexcision and 5 and 10 minutes postexcision. MAIN OUTCOME MEASURES Preexcision and postexcision IOPTH measurements. RESULTS Of the 910 patients, 734 self-reported their race as white (81%); 91, Latino/other (10%); 56, Asian (6%); and 28, African American (3%). African American patients had significantly higher initial preexcision IOPTH levels compared with white patients (348 vs 202 pg/mL; P = .048) and significantly higher 5-minute postexcision IOPTH levels (151 vs 80 pg/mL; P = .01). The 10-minute postexcision IOPTH levels were similar between the 2 groups (52 vs 50 pg/mL). A similar percentage of white and African American patients had a 50% drop in IOPTH level at 10 minutes postexcision. No differences in IOPTH kinetics were observed in the other racial groups examined. CONCLUSIONS African American patients with primary hyperparathyroidism exhibit significantly higher preincision and 5-minute postexcision IOPTH values when compared with white patients. The 10-minute postexcision IOPTH values did not differ between races. The altered IOPTH kinetics identified in African American patients may reflect the severity of biochemical disease but may also be related to genetically predetermined differences in parathyroid hormone metabolism.
Do Neighborhoods Influence Child and Adolescent Development?

The effects of neighborhood characteristics on the development of children and adolescents are estimated, using two data sets, each of which contains information gathered about individual children and the families and neighborhoods in which they reside. There are reasonalby powerful neighborhood effects-particularly effects of the presence of affluent neighbors-on Childhood IQ, teenage births, and school-leaving, even after the differences in the socioeconomic characteristics of families are adjusted for. The study finds that white teenagers benefit more from the presence of affluent neighbors than do black teenagers.
Organizations as Action Generators

Most of the time, organizations generate actions unreflectively and nonadaptively. To justify their actions, organizations create problems, successes, threats and opportunities. These are ideological molecules that mix values, goals, expectations, perceptions, theories, plans, and symbols. The molecules form while people are result watching, guided by the beliefs that they should judge results good or bad, look for the causes of results, and propose needs for action. Because Organizations modify their behavior programs mainly in small increments that make sense to top managers, they change too little and inappropriately, and nearly all organizations disappear within a few years.
Mood Symptoms in Stabilized Patients with Schizophrenia: A Bipolar Type with Predominant Psychotic Features?

BACKGROUND Schizophrenia (SZ) and bipolar disorder (BD) are traditionally distinguished on the basis of progressive deterioration and long-term outcome, but a more dimensional approach is warranted. There are limited data on the occurrence of manic symptoms in patients with schizophrenia. The aim of the current study was to search for patterns in the clinical symptomatology, which may suggest the presence of one or several mood disorders under the label of schizophrenia. SUBJECTS AND METHODS Hundred-seventy-five patients diagnosed with schizophrenia according to DSM-5 were included in the study. The psychometric assessment included the Positive and Negative Syndrome Scale, Young Mania Rating Scale, The Montgomery-Åsberg Depression Rating Scale and the Calgary Depression Scale. The statistical analysis included MANOVA, Pearson Correlation coefficient and principal components analysis. RESULTS Significant subthreshold manic symptoms were present in 25.14% of patients. Mood symptoms correlated with positive symptoms. The PCA revealed a complex structure with 15 factors (one positive, negative, somatic, anxiety, neurocognitive, disorganization and manic, five depressive and three psychomotor/excitement/hostility/violence). CONCLUSION Psychotic mood disorders are often phenotypically indistinguishable from schizophrenia, so it is likely that psychotic affective patients have been misdiagnosed with schizophrenia. The current study suggests that there seem to be patients with mania misdiagnosed as 'schizophrenics' because of the presence of psychotic features, a condition better described as 'schizophreniform bipolar disorder'.
Improving secondary students' academic achievement through a focus on reform reliability: 4- and 9-year findings from the High Reliability Schools project

The authors describe a reform effort in which characteristics derived from High Reliability Organization research were used to shape whole school reform. Longitudinal analyses of outcome data from 12 Welsh secondary schools indicated that 4 years after the effort was initiated, student outcomes at the sites were strongly positive. Additional quantitative and qualitative data, gathered 5 years after the end of the intervention, indicated that the majority of the schools continued using the high reliability principles and continued making strong academic progress. Results are discussed in terms of the original High Reliability Schools model, systemic effects, and sustainability.
Verbal definitions of familiar objects in blind children reflect their peculiar perceptual experience.

BACKGROUND The aim of the present study was to examine to what extent the verbal definitions of familiar objects produced by blind children reflect their peculiar perceptual experience and, in consequence, differ from those produced by sighted children. METHODS Ninety-six visually impaired children, aged between 6 and 14 years, and 32 age-matched sighted children had to define 10 words denoting concrete animate or inanimate familiar objects. RESULTS The blind children evoked the tactile and auditory characteristics of objects and expressed personal perceptual experiences in their definitions. The sighted children relied on visual perception, and produced more visually oriented verbalism. In contrast, no differences were observed between children in their propensity to include functional attributes in their verbal definitions. CONCLUSIONS The results are discussed in line with embodied views of cognition that postulate mandatory perceptuomotor processing of words during access to their meaning.
Loss of Hyperpolarization-activated Cl− Current in Salivary Acinar Cells from Clcn2 Knockout Mice*

ClC-2 is localized to the apical membranes of secretory epithelia where it has been hypothesized to play a role in fluid secretion. Although ClC-2 is clearly the inwardly rectifying anion channel in several tissues, the molecular identity of the hyperpolarization-activated Cl− current in other organs, including the salivary gland, is currently unknown. To determine the nature of the hyperpolarization-activated Cl− current and to examine the role of ClC-2 in salivary gland function, a mouse line containing a targeted disruption of theClcn2 gene was generated. The resulting homozygousClcn2 −/− mice lacked detectable hyperpolarization-activated chloride currents in parotid acinar cells and, as described previously, displayed postnatal degeneration of the retina and testis. The magnitude and biophysical characteristics of the volume- and calcium-activated chloride currents in these cells were unaffected by the absence of ClC-2. Although ClC-2 appears to contribute to fluid secretion in some cell types, both the initial and sustained salivary flow rates were normal inClcn2 −/− mice following in vivostimulation with pilocarpine, a cholinergic agonist. In addition, the electrolytes and protein contents of the mature secretions were normal. Because ClC-2 has been postulated to contribute to cell volume control, we also examined regulatory volume decrease following cell swelling. However, parotid acinar cells from Clcn2 −/−mice recovered volume with similar efficiency to wild-type littermates. These data demonstrate that ClC-2 is the hyperpolarization-activated Cl− channel in salivary acinar cells but is not essential for maximum chloride flux during stimulated secretion of saliva or acinar cell volume regulation.
Thoracic injury: a review of 276 cases.

OBJECTIVE Chest injury, one of the most important aspects of trauma, directly accounts for 25% of all trauma-related deaths and plays a major contributing role in another 25% of trauma deaths. This paper aimed to explore the spectrum and outcome of thoracic injuries seen in a multi centric study of trauma patients. METHODS A total of 276 consecutive trauma patients in 6 general hospitals were analyzed. The feature of injury, injury severity score (ISS), clinical treatment and mortality were recorded in a prospective manner and analyzed retrospectively. Multiple logistic regression analysis was used to determine the independent predictors of mortality following the chest trauma. RESULTS There were 246 males (89.1%) and 30 females (10.9%) ranging from 3 to 80 years with a mean age of (34+/-17) years. Road traffic accident was the main cause of injury, especially for pedestrians, followed by stab wound (89 cases, 32.1%) and falling injuries (32 cases, 11.6%), respectively. Haemothorax or pneumothorax (50.4%) and rib fracture (38.6%) were the most common types of chest injury. Extremity fracture was the most common associated injury with the rate of 37% ( 85/230), followed by head injury (25.2%) and abdominal trauma (19.6%). These injuries contributed significantly to the morbidity and mortality of trauma patients. CONCLUSIONS According to the results, most patients with chest injury can be treated conservatively with close observation and tube thoracostomy. The presence of blunt trauma, head injury and abdominal injury independently adversely affect mortality after chest trauma. It is necessary to investigate the causes and patterns of injuries resulting from stab wound for effective prevention.
Social-Emotional Competence as Support for School Readiness: What Is It and How Do We Assess It?

The overall issue of assessment during early childhood, and its relation to school readiness and other decisions, is currently widely debated. Expanding early childhood education and child care enrollments, better scientific knowledge about early childhood development, and decisions about public spending, necessitate careful consideration of which assessment tools to use, as well as why and when to use them. More specifically, the disconnection between the importance of social and emotional domains of development, and their status within educational programming and assessment, has long been lamented. The last several years have, however, witnessed a blossoming of attention to these areas during early childhood, as crucial for both concurrent and later well-being and mental health, as well as learning and academic success. Teachers view children's "readiness to learn" and "teachability" as marked by positive emotional expressiveness, enthusiasm, and ability to regulate emotions and behaviors. Based on these assertions, I suggest a battery of preschool social–emotional outcome measures, tapping several constructs central to emotional and social competence theory, specifically emotional expression, emotion regulation, emotion knowledge, social problem solving, and positive and negative social behavior.
Cardioprotective Role of P38 MAPK During Myocardial Infarction Via Parallel Activation of α‐Crystallin B and Nrf2

Myocardial infarction (MI) is defined as cardiac cell death due to prolonged ischemia. Although necrotic cell death was considered to be solely responsible for myocyte death during MI, it was recently revealed that apoptosis also plays its part in this death process. Our laboratory has recently shown that endoplasmic reticulum (ER) stress‐induced apoptosis is the predominant route for apoptosis during MI and the conventional mitochondrial pathway is bypassed by activation of a small heat shock protein α‐crystallin B (CRYAB). Since CRYAB is a direct target of P38 mitogen‐activated protein kinase (MAPK) cascade, we were prompted to check the role of P38 MAPK in 20‐week‐old male Wister rats immediately after infarct formation. Interestingly, parallel activation of mitochondrial apoptotic pathway with an increase in ER stress‐induced apoptotic load was observed along with decreased activation of CRYAB and Nrf2 (a pro‐survival protein activated in response to ER stress) in MI rats treated with SB203580, a specific inhibitor of P38α and P38β compared to the MI alone. As a cumulative effect, this inhibitor treatment also resulted in significant increase in the levels of caspase3 activity and TUNEL positivity, the end point apoptotic markers. Furthermore, SB203580‐treated hypoxic adult cardiomyocytes showed formation of desmin aggregates which were previously associated with impaired cardiac function. Thus, this study shows for the first time the precise mechanism by which P38 MAPK plays a pro‐survival role and confers protection of cardiomyocytes, during infarct formation. J. Cell. Physiol. 229: 1272–1282, 2014. © 2014 Wiley Periodicals, Inc.
Life Events and Recurrent Depression in Borderline and Antisocial Personality Disorders

The temporal relationship between life events and the recurrence of depression was ascertained in a prospectively followed sample of adults with borderline or antisocial personality disorders or bipolar type II affective disorder. The 8-week period of risk immediately following a life event was temporally associated with annualized rates of depression recurrence (depending on the definition) 1.9 to 2.9 times higher compared to periods when no life events occurred. Whether rated by self-report or by objective raters, more stressful events were associated with higher rates of depression. Events caused by the subject were also associated with higher rates of depression. The pathogenicity of interpersonal exit events was not significantly supported overall, but there were differential trends depending on personality psychopathology. Higher scores on the Borderline Personality Disorder Scale predicted higher recurrence rates of depressive symptoms and nonacute major depressive episodes following life events, e.
The Quality of Life of Family Caregivers of Adults with Intellectual Disabilities in Taiwan

Background Taiwanese family carers of people with intellectual disabilities not only suffer from long-term stress but also need to cope with social difficulties. The aim of this study is to evaluate the quality of life (QOL) among family carers of people with intellectual disabilities. Materials and methods A census interview survey was conducted in Hsin-Chu City in Taiwan and included the primary family caregivers of 792 adults with intellectual disability who were living with their families. The survey packet contained the WHOQOL-BREF Taiwan-version scale with four core domains and the activities of daily life/instrumental activities of daily life (ADL/IADL) scales. Results The mean score for ‘physical’ was highest and that for ‘environment’ was lowest. The strongest predictors of caregivers QOL were the caregiver's health status, their family income and the level of severity of the intellectual disability of the adult. Conclusions The results of the study support the need to expand services and individualize support to families of adults with intellectual disability living in family homes.
Mechanism of anteroposterior axis specification in vertebrates. Lessons from the amphibians.

Interest in the problem of anteroposterior specification has quickened because of our near understanding of the mechanism in Drosophila and because of the homology of Antennapedia-like homeobox gene expression patterns in Drosophila and vertebrates. But vertebrates differ from Drosophila because of morphogenetic movements and interactions between tissue layers, both intimately associated with anteroposterior specification. The purpose of this article is to review classical findings and to enquire how far these have been confirmed, refuted or extended by modern work. The "pre-molecular" work suggests that there are several steps to the process: (i) Formation of anteroposterior pattern in mesoderm during gastrulation with posterior dominance. (ii) Regional specific induction of ectoderm to form neural plate. (iii) Reciprocal interactions from neural plate to mesoderm. (iv) Interactions within neural plate with posterior dominance. Unfortunately, almost all the observable markers are in the CNS rather than in the mesoderm where the initial specification is thought to occur. This has meant that the specification of the mesoderm has been assayed indirectly by transplantation methods such as the Einsteckung. New molecular markers now supplement morphological ones but they are still mainly in the CNS and not the mesoderm. A particular interest attaches to the genes of the Antp-like HOX clusters since these may not only be markers but actual coding factors for anteroposterior levels. We have a new understanding of mesoderm induction based on the discovery of activins and fibroblast growth factors (FGFs) as candidate inducing factors. These factors have later consequences for anteroposterior pattern with activin tending to induce anterior, and FGF posterior structures. Recent work on neural induction has implicated cAMP and protein kinase C (PKC) as elements of the signal transduction pathway and has provided new evidence for the importance of tangential neural induction. The regional specificity of neural induction has been reinvestigated using molecular markers and provides conclusions rather similar to the classical work. Defects in the axial pattern may be produced by retinoic acid but it remains unclear whether its effects are truly coordinate ones or are concentrated in certain regions of high sensitivity. In general the molecular studies have supported and reinforced the "pre-molecular ones". Important questions still remain: (i) How much pattern is there in the mesoderm (how many states? ) (ii) How is this pattern generated by the invaginating organizer? (iii) Is there one-to-one transmission of codings to the neural plate? (iv) What is the nature of the interactions within the neural plate? (v) Are the HOX cluster genes really the anteroposterior codings?
[Factor analysis of the health related quality of life of patients with stable chronic obstructive pulmonary disease].

OBJECTIVE To identify factors associated with the health-related quality of life (HRQL) perceived by patients with stable chronic obstructive pulmonary disease (COPD). PATIENTS AND METHODS DESIGN Prospective cohort study. SUBJECTS Patients with stable COPD (n = 204, alpha = 0.05, d = 6.9%). MEASURES AND INTERVENTIONS: For every patient we recorded sociodemographic and treatment data,severity of dyspnea, and the results of gasometry and lung function and stress testing, as well as responses to the Chronic Respiratory Disease Questionnaire (CRDQ). After studying the associations between variables we carried out factor analysis of those that were significantly related to HRQL. RESULTS Men made up 91.7% of the cohort. The mean age (standard deviation)was 71 (9), FEV1% was 45 (16) and FEV1/FVCwas 48 (10). HRQL was statically related to age, weight, body mass index (BMI), economic status, educational status, chronic treatment with oral corticosteroids, ODCA, PaO2, oxygen saturation, alveolar-arterial oxygen gradient, absolute FEV1, FEV1%, post-bronchodilatation FEV1, absolute FVC, FVC%, distance walked in six minutes, oxygen saturation before the walking test and lowest oxygen saturation during the test,difference in dyspnea before and after the test measured on a visual analog scale. Factor analysis reduced the main variables to six, which explained 74.6% of the variance, as follows: Factor1 PaO2, oxygen saturation and alveolar-arterial oxygen gradient (33.7%); Factor 2 absolute FEV1,FEV1%, FEV1 after bronchodilatation, absolute FVC and FVC% (11.9%); Factor 3 eight and BMI (8.8%); Factor 4 age, severity of dyspnea and walking test distance (8.4%);Factor 5: corticosteroid dependence and domiciliary oxygen therapy(6.3%); and Factor 6: economic and educational status (5.5%). CONCLUSION HRQL in stable COPD patients is partially related to severity of respiratory insufficiency, airflow obstruction, nutritional status, exercise capacity, severity of disease, and socioeconomic status.
Helicobacter pylori Activates IL‐6‐STAT3 Signaling in Human Gastric Cancer Cells: Potential Roles for Reactive Oxygen Species

Recent studies have shown that Helicobacter pylori (H. pylori) activates signal transducer and activator of transcription 3 (STAT3) that plays an important role in gastric carcinogenesis. However, the molecular mechanism underlying H. pylori‐mediated STAT3 activation is still not fully understood. In this study, we investigated H. pylori‐induced activation of STAT3 signaling in AGS human gastric cancer cells and the underlying mechanism.
Probationer training for neighborhood policing in England and Wales: fit for purpose?

Purpose – The purpose of this paper is to apply a consensus‐based definition of the adult‐learning theory of andragogy to police probationer training in England and Wales and to identify whether the requisite learning outcomes, when aligned to a community‐oriented policing strategy, are adequately addressed by the current police training methodology.Design/methodology/approach – The reasons behind the new approach to police probationer training are identified with reference to British government literature. Proposed revisions to the structure of the training regime are identified, taking cognizance of the community‐oriented neighborhood‐policing strategy advocated by the British government. Six criteria of a consensus‐based definition of the theory of andragogy are applied to the police model of training to establish whether or not it conforms to true andragogical principles. Furthermore, the proposals for a revised probationer program are examined to identify whether the training methodology and curricul.