Miracle-dz/UniFAR-FTUs huggingface dataset:
Treatment of Osteochondritis Dissecans of the Knee with Autologous Chondrocyte Transplantation: Results at Two to Ten Years

Background: Osteochondritis dissecans of the knee is a challenging clinical problem. We previously reported on the early successful results of autologous chondrocyte transplantation for the treatment of focal cartilage defects. The purpose of the present study was to assess the intermediate to long-term results of this technique in a large group of patients with osteochondritis dissecans.Methods: Fifty-eight patients with radiographically documented osteochondritis dissecans of the knee underwent treatment with autologous chondrocyte transplantation between 1987 and 2000 and were assessed clinically with use of standard rating scales. Twenty-two patients consented to arthroscopic second-look evaluation of graft integrity.Results: The mean age of the patients at the time of autologous chondrocyte transplantation was 26.4 years (range, fourteen to fifty-two years). Seven patients were less than eighteen years old. Thirty-five patients (60%) had juvenile-onset disease, and forty-eight patients (83%) had had a mean of 2.1 prior operations. The defect was located on the medial femoral condyle in thirty-nine patients and on the lateral femoral condyle in nineteen. The mean lesion size was 5.7 cm 2 (range, 1.5 to 12.0 cm 2 ), and the mean defect depth was 7.8 mm (range, 4 to 15 mm). After a mean duration of follow-up of 5.6 years, 91% of the patients had a good or excellent overall rating on the basis of a clinician evaluation and 93% had improvement on a patient self-assessment questionnaire. The Tegner-Wallgren, Lysholm, and Brittberg-Peterson VAS scores were all improved. The macroscopic quality of graft integrity averaged 11.2 on a 12-point scale, with only one graft having a score of <9 points. Two patients had a failure of treatment in the early postoperative period. Only one patient who had had a good or excellent rating at two years had a decline in clinical status at the time of the latest follow-up.Conclusions: Treatment of osteochondritis dissecans lesions of the knee with autologous chondrocyte transplantation produces an integrated repair tissue with a successful clinical result in >90% of patients. We recommend the wider use of autologous chondrocyte transplantation for this condition.
Defined mutations in a small region of the brome mosaic virus 2 gene cause diverse temperature-sensitive RNA replication phenotypes

The central portion of the brome mosaic virus (BMV) 2a protein represents the most conserved element among the related RNA replication components of a large group of positive-strand RNA viruses of humans, animals, and plants. To characterize the functions of the 2a protein, mutations were targeted to a conserved portion of the 2a gene, resulting in substitutions between amino acids 451 and 484. After the temperature profile of wild-type BMV RNA replication was defined, RNA replication by nine selected mutants was tested in barley protoplasts at permissive (24 degrees C) and nonpermissive (34 degrees C) temperatures. Four mutants did not direct RNA synthesis at either temperature. Various levels of temperature-sensitive (ts) replication occurred in the remaining five mutants. For two ts mutants, no viral RNA synthesis was detected at 34 degrees C, while for two others, an equivalent reduction in positive- and negative-strand RNA accumulation was observed. For one mutant, positive-strand accumulation was preferentially reduced over negative-strand accumulation at 34 degrees C. Moreover, this mutant and another displayed preferential suppression of genomic over subgenomic RNA accumulation at both 24 and 34 degrees C. The combination of phenotypes observed suggests that the 2a protein may play a role in the differential initiation of specific classes of viral RNA in addition to a previously suggested role in RNA elongation.
The Effect of Repeated Bilateral Electroconvulsive Therapy on Seizure Threshold

Seizure threshold was measured by empirical titration in 28 patients referred for bilateral electroconvulsive therapy to treat depressive illness at the outset of treatment and after another six treatments. No patient was given antiepileptic drug treatment, and anesthetic technique and concomitant psychotropic drug treatment were fixed. The average (± SD) initial seizure threshold measured by set charge was 79.5 mC (± 33.4 mC), and this increased to 95.5 mC (± 37.9 mC). The average percentage increase was 22.8% (95% confidence interval, 13.7% to 31.8%). The seizure threshold measured by set charge did not change in 15 patients (54%), and there was no significant relation between change in seizure threshold and patient sex, change in seizure duration measured by cuff technique, or global clinical improvement during the course of treatment.
A Theory of Focal Points

The paper presents a theoretical framework that distinguishes between the strategic structure of a game (the existential game) and the way the players describe the game to themselves. Each player works with a private description of the game in which strategies are identified by labels; labels are generated by a stochastic labeling procedure. Each player chooses a decision rule which, for each possible private description, picks one of the available strategy labels. A criterion of collective rationality is applied to choices among decision rules. The implications of collective rationality are explored for a range of games with different labeling procedures. Copyright 1995 by Royal Economic Society.
Accounting Harmonization and Compliance in Applying IASB Standards: An Empirical Survey about the First Time Adoption of IAS 7 by Italian Listed Groups

This paper deals with the First Time Adoption (FTA) of International Accounting Standards Board (IASB) standards by Italian entities, focusing on the cash flow statement (CFS) whose rules are stated by International Accounting Standards 7 (IAS 7). The purpose of this paper is to investigate both the degree of harmonization and compliance in applying IAS 7. To achieve this purpose, the research has been developed by analyzing a sample of 101 financial statements of Italian listed groups issued with reference to 2005. The results of this research show a high degree of heterogeneity in applying IASB standards and a high degree of noncompliance with IAS 7 by Italian groups. The high degree of heterogeneity could impair the comparability of financial statements across entities, requiring further efforts by IASB to reduce options permitted in its standards. The high degree of noncompliance creates the risk of misleading users who read audited financial statements thinking they are prepared according to IASB standards.
Differential transcriptome profiling of chilling stress response between shoots and rhizomes of Oryza longistaminata using RNA sequencing

Rice (Oryza sativa) is very sensitive to chilling stress at seedling and reproductive stages, whereas wild rice, O. longistaminata, tolerates non-freezing cold temperatures and has overwintering ability. Elucidating the molecular mechanisms of chilling tolerance (CT) in O. longistaminata should thus provide a basis for rice CT improvement through molecular breeding. In this study, high-throughput RNA sequencing was performed to profile global transcriptome alterations and crucial genes involved in response to long-term low temperature in O. longistaminata shoots and rhizomes subjected to 7 days of chilling stress. A total of 605 and 403 genes were respectively identified as up- and down-regulated in O. longistaminata under 7 days of chilling stress, with 354 and 371 differentially expressed genes (DEGs) found exclusively in shoots and rhizomes, respectively. GO enrichment and KEGG pathway analyses revealed that multiple transcriptional regulatory pathways were enriched in commonly induced genes in both tissues; in contrast, only the photosynthesis pathway was prevalent in genes uniquely induced in shoots, whereas several key metabolic pathways and the programmed cell death process were enriched in genes induced only in rhizomes. Further analysis of these tissue-specific DEGs showed that the CBF/DREB1 regulon and other transcription factors (TFs), including AP2/EREBPs, MYBs, and WRKYs, were synergistically involved in transcriptional regulation of chilling stress response in shoots. Different sets of TFs, such as OsERF922, OsNAC9, OsWRKY25, and WRKY74, and eight genes encoding antioxidant enzymes were exclusively activated in rhizomes under long-term low-temperature treatment. Furthermore, several cis-regulatory elements, including the ICE1-binding site, the GATA element for phytochrome regulation, and the W-box for WRKY binding, were highly abundant in both tissues, confirming the involvement of multiple regulatory genes and complex networks in the transcriptional regulation of CT in O. longistaminata. Finally, most chilling-induced genes with alternative splicing exclusive to shoots were associated with photosynthesis and regulation of gene expression, while those enriched in rhizomes were primarily related to stress signal transduction; this indicates that tissue-specific transcriptional and post-transcriptional regulation mechanisms synergistically contribute to O. longistaminata long-term CT. Our findings provide an overview of the complex regulatory networks of CT in O. longistaminata.
Learning processes, their impact on innovation performance and the moderating role of radicalness

Purpose – This study aims to extend the proposal of Holmqvist with regard to organisational processes of learning and their impact on firm performance.Design/methodology/approach – Based on a survey of 187 firms, the paper shows that certain organisational processes of learning are related to innovation performance. Further, it investigates the moderating role of product radicalness on such relationships.Findings – Based on a survey of 187 firms, the paper shows that certain organisational processes of learning are related to innovation performance. Further, it investigates the moderating role of product radicalness on such relationships and proves that the other two types of organisational learning processes are not related to innovation performance.Originality/value – The innovation performance of collaboration between firms has not received a great deal of attention in the literature. This research paper offers some guidelines on how to obtain great advantages from this collaboration.
Is cultural heritage really important for tourists? A contingent rating study

In this article we present the results of a contingent rating study carried out on a sample of tourisits visiting Scicli, a Sicilian town known for its baroque heritage. In particular, we focus on different attributes of tourism products – namely, season, accommodation and cultural heritage – to study how much each of these attributes weights in tourists’ preferences. We also study how the socio-demographic characteristics of people affect their evaluation of the different attributes of tourism products. The heritage endowment appears to be far from being the most important factor; this result is consistent across different socio-demographic subgroups of interviewed persons.
Studying the Studies: An Overview of Recent Research Into Taxation Operating Costs

Studies into the operating costs of taxation compliance costs for taxpayers and administrative costs for revenue authorities have flourished in recent years. This paper provides an overview of these studies, and reveals both the breadth and the depth of the research in this area. The paper focuses upon studies that have taken place in the last 20 years or so, although the paper also briefly considers the broader historical context, including the reasons why research into tax operating costs has apparently flourished after some initial neglect. A summary of most of the major (and some minor) administrative and compliance cost studies that have been published (and some that have not been published) since 1980 is contained in an appendix. This summary highlights the geographical spread of operating cost research, the variety of taxes and aspects of tax systems that have been studied, and the range of methodologies employed. The outcomes of the research are also summarised. A key thesis of the paper is that tax law design should not take place without clear recognition of the impact of the proposed changes on the operating costs of the tax system. Sensible tax law design must be informed by an understanding of the impact that design will have on the burden that taxpayers will face and the administrative costs that the revenue authority will be required to carry.
Media-political skills, Candidate selection methods and electoral success

The analyses concentrate on the influences of the media and political skills of political actors on their electoral success. Many believe that demonstrating media skills is crucial for electoral success because it helps political actors to persuade media consumers to vote for them; but in some candidate selection methods, such as when a single leader selects the candidates, the media might not be an important factor. Therefore, the analyses take into account the interaction of media-political skills of political actors with candidate selection methods. This raises the question whether the democratisation of selection methods, now occurring in many countries, is making media-political skills more important. Multiple regression analyses show that media-political skills have a strong impact on the electoral success of 81 Israeli Members of the Knesset. They reveal a clear interaction with selection methods, and show that media-political skills have a greater impact in the more democratic methods of selection. The level of incumbents' parliamentary activity was found to have no impact at all on their electoral success in all candidate selection methods.
The Trade Creation Effect of Immigrants: Evidence from the Remarkable Case of Spain

There is abundant evidence that immigrant networks are associated with larger exports from the country where they settle to their countries of origin. The direction of causality of this association is less clearly established. Also, we do not know to what extent these increased exports are due to an increase in the number of exporting firms (i.e. the extensive margin of trade) or due to larger values exported by existing firm (i.e. the intensive margin). Using micro data on individual trade transactions from Spanish provinces between 1995 and 2008 and data on the stock of immigrants in those provinces by country of origin we can make progress on both fronts. The richness of our data allows us to control for a large set of fixed effects and to use an instrumental variable strategy to isolate the export creation effect of new immigrants. We are also able to quantify the impact of immigrants on the intensive and extensive margin of trade and how it varies between homogeneous, moderately differentiated and differentiated goods. Our findings can be interpreted, in the light of the Chaney (2008) gravity model, as consistent with the idea that immigrants reduce the fixed costs of trade. As implied by a decrease in fixed trade costs in that model we find that immigrants significantly increase exports (elasticity of 0.10), that the effect is almost entirely due to an increase in the extensive margin and that the effect is somewhat stronger for differentiated goods.
Disaggregate Energy Consumption, Agricultural Output and Economic Growth in Pakistan

The basic goal of the study is to analyse the impact of energy consumption (i.e., electricity, oil and gas) on economic growth and agriculture sector output in Pakistan. It is desirable to find out relationship between disaggregate energy consumption, economic growth and agricultural sector output of Pakistan because energy crisis has become a central issue now-a-days. Production sector of Pakistan relies on electricity and gas consumption to large extent and these sources of energy are falling short because of many reasons which is disrupting output and consequently exports and real output of the country. To analyse the relationship, we employed time series data from 1972 to 2011. In order to find out long run and short run effects of energy consumption on agricultural output and economic growth, ARDL modelling approach to cointegration is applied after scrutinising the stationarity of data through ADF Test. Where, bound testing procedure is utilised for cointegration to judge the existence of long run relationship among variables and ECM models are formulated for short run analysis. Our econometric models include agricultural output and economic growth as dependant variables and electricity, coal and gas consumption as independent and core variables. The findings of the study indicate that gas and oil consumption are important determinants of economic growth and agricultural output.
Cultural Constraints on Innovation‐Based Growth

type="main" xml:lang="en"> To what extent does the cultural composition of a society impose a constraint on its long-run growth potential? We study this question in the context of an innovation-based model of growth where cultural attitudes are endogenously transmitted from one generation to the next. Focusing on attitudes regarding patience, we analyze the two-way interaction between economic growth and the intergenerational transmission of patience. Exploiting this interaction, we compare the long-run growth performance of a culturally heterogeneous society where patience is initially underrepresented in the population with a culturally homogeneous society where all agents are perfectly patient. Our main result is that in the absence of any intrinsic preferences of patient parents to transmit their attitudes to their children, the development paths of the two societies are bound to diverge, with the culturally heterogeneous society experiencing lower growth rates. Yet, if patient parents ceteris paribus prefer their children to be patient like them, we show that the two societies can in the long run grow at the same rate. (JEL D91, E24, O30, O40, Z10)
Staff Reactions Toward Lesbian, Gay, or Bisexual (LGB) People Living in Residential Aged Care Facilities (RACFs) Who Actively Disclose Their Sexual Orientation

Fifty-three staff members currently working in residential aged care facilities located in Barcelona, Spain, were asked about the way they would react if a resident told them that he or she felt sexually attracted and had maintained sexual relationships with another resident of the same gender. Acceptance of non-heterosexual sexual orientation was a frequent answer, and around one in four professionals stated that they would try helping the resident in question, by offering a private space or giving some emotional support. However, some reactions were not consistent with a respectful approach toward sexual diversity, as, for instance, informing the resident’s family or advising the resident to keep his or her sexual orientation hidden. We highlight the importance of developing formal policies and offering formal training to staff in order to address the specific needs of older LGB people living in RACFs.
Some factors affecting the absorption of paracetamol

Blood concentration and urinary excretion data demonstrated that subjects who had ingested 1 g of paracetamol after fasting overnight absorbed the drug up to 5 times more rapidly but to the same extent as when they ingested the drug after a substantial high carbohydrate breakfast. Subjects who had ingested 1 g of paracetamol immediately before sleep at night excreted up to 36% less than when they took the drug at 8.30 a.m.
Reputational Threat and Image Repair Strategies: Northern Ireland Water’s Crisis Communication in a Freeze/Thaw Incident

December 2010 saw exceptionally harsh winter weather cause major water supply disruption for thousands of Northern Ireland’s citizens. Sustained low temperatures followed by a rapid thaw led to burst water pipes on an unprecedented scale, triggering a water shortage crisis that attracted global media attention. Government-owned Northern Ireland Water (NI Water) received severe criticism for their response to the incident. This article analyzes the reputational threat posed by the crisis and examines the image repair strategies employed by NI Water before, during, and after the event. The crisis was complex and dynamic, requiring a multistrategy response including bolstering, corrective action, mortification, and shifting the blame. However, this was ultimately deemed largely ineffectual since it was more operationally focused than consumer-oriented. The case study adds to the limited research in public sector crisis communication and illustrates how politics and the governmental organizational structure complicated the threat to NI Water’s image.
Chaos Control: Climate Stabilization by Closing the Global Carbon Cycle

The central idea behind the control of chaotic systems is that the same feedbacks that destabilize a complex system producing chaotic dynamics can be used to relatively easily stabilize it. While many argue that the carbon cycle feedbacks are destabilizing the climate, it will be argued here that those same feedbacks can stabilize the climate. The controlling variable is the amount of CO2 in the atmosphere and the control strategy is to close the global carbon cycle of our planet, including human and planetary components, so the ambient concentration is fixed. The stabilization requires less energy per year than used to stabilize the climate in our buildings and for less cost than 1% of the global GDP.
The Success of Acquisitions: Evidence from Disvestitures

This paper studies a sample of large acquisitions completed between 1971 and 1982. By the end of 1989, acquirers have divested almost 44 percent of the target companies. The authors characterize the ex post success of the divested acquisitions and consider 34 percent to 50 percent of classified divestitures as unsuccessful. Acquirer returns and total (acquirer and target) returns at the acquisition announcement are significantly lower for unsuccessful divestitures than for successful divestitures and acquisitions not divested. Although diversifying acquisitions are almost four times more likely to be divested than related acquisitions, they do not find strong evidence that diversifying acquisitions are less successful than related ones. Copyright 1992 by American Finance Association.
Rethinking an old empirical puzzle: econometric evidence on the forward discount anomaly

Using both semiparametric and parametric estimation methods, this paper corroborates earlier findings of fractionally integrated behaviour in the forward premium. Two new explanations are also proposed to help reconcile earlier conflicting empirical evidence on the time series properties of the forward premium. Traditional regression approaches used to test the forward rate unbiasedness hypothesis are then evaluated, including regression in levels, in returns (Fama's, 1984, regression), and in error-correction format. Interesting statistical and|or interpretive implications are found in all three cases. For example, the predictions of the appropriate nonstandard limit theory are consistent with many of the standard empirical results reported from Fama's regression, including the commonly occurring, yet puzzling negative correlations between spot returns and the forward premium. It is suggested that the principal failure of unbiasedness, may be due instead to the difference in persistence between these two series. Copyright © 2001 John Wiley & Sons, Ltd.