Miracle-dz/UniFAR-FTUs huggingface dataset:
International Journal of Production Research a Multi-variable Approach to Supplier Segmentation a Multi-variable Approach to Supplier Segmentation

This article may be used for research, teaching, and private study purposes. Any substantial or systematic reproduction, redistribution, reselling, loan, sub-licensing, systematic supply, or distribution in any form to anyone is expressly forbidden. The publisher does not give any warranty express or implied or make any representation that the contents will be complete or accurate or up to date. The accuracy of any instructions, formulae, and drug doses should be independently verified with primary sources. The publisher shall not be liable for any loss, actions, claims, proceedings, demand, or costs or damages whatsoever or howsoever caused arising directly or indirectly in connection with or arising out of the use of this material. The aim of this paper is to develop a new approach to supplier segmentation that considers the various variables used in existing literature to segment suppliers. A literature review reveals a serious problem from a management perspective. The problem is that many different supplier segmentation methods have been proposed in the last three decades, each of which uses different segmentation variables and hence results in different segments. An overarching supplier segmentation method, considering various segmentation variables, is lacking. Based on an extensive literature review, we have analysed the current methods and we conclude that the literature on supplier segmentation can be divided into three different schools of thoughts. By clearly identifying the deficiencies of the existing theory on supplier segmentation, we developed a new approach. As the basis for this new approach, we developed three requirements to make an overarching approach to supplier segmentation. Firstly, supplier segmentation should be based on their long-term potential, which we propose to assess in terms of supplier capabilities and willingness to cooperate. Secondly, other functional areas beyond purchasing have to be considered when segmenting suppliers. Thirdly, supplier segmentation should be viewed as a step in a longitudinal process that includes selecting suppliers, segmenting them, managing the relationship with them and actively developing their role over time. We illustrate the proposed approach by segmenting the suppliers of a company in the food industry. 1. Introduction Faced with a competitive global market, firms have downsized, focused on core competencies and attempted to achieve competitive advantage by managing their relationships with suppliers more effectively (Tan et al. 1999). The relationships between buyers and suppliers in a supply chain management (SCM) context are investigated in various recent studies. In most cases, the main objective is to …
Alternatively Spliced Homologous Exons Have Ancient Origins and Are Highly Expressed at the Protein Level

Alternative splicing of messenger RNA can generate a wide variety of mature RNA transcripts, and these transcripts may produce protein isoforms with diverse cellular functions. While there is much supporting evidence for the expression of alternative transcripts, the same is not true for the alternatively spliced protein products. Large-scale mass spectroscopy experiments have identified evidence of alternative splicing at the protein level, but with conflicting results. Here we carried out a rigorous analysis of the peptide evidence from eight large-scale proteomics experiments to assess the scale of alternative splicing that is detectable by high-resolution mass spectroscopy. We find fewer splice events than would be expected: we identified peptides for almost 64% of human protein coding genes, but detected just 282 splice events. This data suggests that most genes have a single dominant isoform at the protein level. Many of the alternative isoforms that we could identify were only subtly different from the main splice isoform. Very few of the splice events identified at the protein level disrupted functional domains, in stark contrast to the two thirds of splice events annotated in the human genome that would lead to the loss or damage of functional domains. The most striking result was that more than 20% of the splice isoforms we identified were generated by substituting one homologous exon for another. This is significantly more than would be expected from the frequency of these events in the genome. These homologous exon substitution events were remarkably conserved—all the homologous exons we identified evolved over 460 million years ago—and eight of the fourteen tissue-specific splice isoforms we identified were generated from homologous exons. The combination of proteomics evidence, ancient origin and tissue-specific splicing indicates that isoforms generated from homologous exons may have important cellular roles.
Multiple Cost Functions and Regularization Options for Improved Retrieval of Leaf Chlorophyll Content and LAI through Inversion of the PROSAIL Model

Lookup-table (LUT)-based radiative transfer model inversion is considered a physically-sound and robust method to retrieve biophysical parameters from Earth observation data but regularization strategies are needed to mitigate the drawback of ill-posedness. We systematically evaluated various regularization options to improve leaf chlorophyll content (LCC) and leaf area index (LAI) retrievals over agricultural lands, including the role of (1) cost functions (CFs); (2) added noise; and (3) multiple solutions in LUT-based inversion. Three families of CFs were compared: information measures, M-estimates and minimum contrast methods. We have only selected CFs without additional parameters to be tuned, and thus they can be immediately implemented in processing chains. The coupled leaf/canopy model PROSAIL was inverted against simulated Sentinel-2 imagery at 20 m spatial resolution (8 bands) and validated against ﬁeld data from the ESA-led SPARC (Barrax, Spain) campaign. For all 18 considered CFs with noise introduction and opting for the mean of multiple best solutions considerably improved retrievals; relative errors can be twice reduced as opposed to those without these regularization options. M-estimates were found most successful, but also data normalization inﬂuences the accuracy of the retrievals. Here, best LCC retrievals were obtained using a normalized “L1 -estimate” function with a relative error of 17.6% (r2 : 0.73), while best LAI retrievals were obtained through non-normalized “least-squares estimator” (LSE) with a relative error of 15.3% (r2 : 0.74).
Appearance-Based Loop Closure Detection for Online Large-Scale and Long-Term Operation

In appearance-based localization and mapping, loop-closure detection is the process used to determinate if the current observation comes from a previously visited location or a new one. As the size of the internal map increases, so does the time required to compare new observations with all stored locations, eventually limiting online processing. This paper presents an online loop-closure detection approach for large-scale and long-term operation. The approach is based on a memory management method, which limits the number of locations used for loop-closure detection so that the computation time remains under real-time constraints. The idea consists of keeping the most recent and frequently observed locations in a working memory (WM) that is used for loop-closure detection, and transferring the others into a long-term memory (LTM). When a match is found between the current location and one stored in WM, associated locations that are stored in LTM can be updated and remembered for additional loop-closure detections. Results demonstrate the approach's adaptability and scalability using ten standard datasets from other appearance-based loop-closure approaches, one custom dataset using real images taken over a 2-km loop of our university campus, and one custom dataset (7 h) using virtual images from the racing video game “Need for Speed: Most Wanted”.
Integrated workforce capacity and inventory management under temporary labor supply uncertainty

In a manufacturing environment with volatile demand, inventory management can be coupled with dynamic capacity adjustments for handling the fluctuations more effectively. In this study, we consider the problem of integrated capacity and inventory management under non-stationary stochastic demand and flexible capacity uncertainty. The capacity planning problem is investigated from the workforce planning perspective where the capacity can be temporarily increased by utilizing contingent workers from an external labor supply agency. The contingent capacity received from the agency is subject to an uncertainty, but the supply of a certain number of workers can be guaranteed through contracts. We formulate a dynamic programming model to make the optimal capacity decisions at a tactical level (permanent workforce size and contracted number of workers) as well as the operational level (number of workers to be requested from the external labor supply agency in each period), integrated with the optimal operational decision of how much to produce in each period. We analyze the characteristics of the optimal policies and we conduct an extensive numerical analysis that helps us provide several managerial insights.
Arsenic trioxide inhibits translation of mRNA of bcr-abl, resulting in attenuation of Bcr-Abl levels and apoptosis of human leukemia cells.

Present studies demonstrate that treatment with arsenic trioxide (AT) lowered ectopically expressed or endogenous levels of Bcr-Abl protein, as well as induced apoptosis of Bcr-Abl-expressing cultured and primary chronic myeloid leukemia cells, including those refractory to imatinib mesylate. Treatment with AT neither affected bcr-abl mRNA transcript levels nor promoted the proteasomal degradation of Bcr-Abl. Importantly, in [(35)S]methionine-labeled leukemia cells, exposure to AT rapidly lowered the levels of the newly synthesized Bcr-Abl, indicating inhibition of bcr-abl mRNA translation. Treatment with AT rapidly inhibited the activity of 3-phosphoinositide-dependent protein kinase-1, as well as of p70 S6 kinase-1. p70 S6 kinase-1 is known to be a positive regulator of the translation of a group of mRNAs that possesses a long and highly structured 5'-untranslated region (UTR) containing a tract of oligopyrimidines (TOP). Because bcr-abl mRNA was discovered to possess a long and highly structured 5'-UTR containing a 12-pyrimidine TOP sequence in its 5'-UTR, we determined the effect of AT in Jurkat cells with ectopic expression of a 5'-UTR-deleted mutant of the bcr-abl gene, i.e., Jurkat/Bcr-Abl (5'UTR-) cells. Treatment with AT neither lowered the levels of the 5'-UTR-deleted mutant of Bcr-Abl nor induced apoptosis of Jurkat/Bcr-Abl (5'UTR-) cells. Taken together, these findings demonstrate a novel mechanism by which AT down-regulates Bcr-Abl levels and induces apoptosis of Bcr-Abl-positive chronic myelogenous leukemia cells.
Operation of a Six-Phase Induction Machine Using Series-Connected Machine-Side Converters

This paper discusses the operation of a multiphase system, which is aimed at both variable-speed drive and generating (e.g., wind energy) applications, using back-to-back converter structure with dual three-phase machine-side converters. In the studied topology, an asymmetrical six-phase induction machine is controlled using two three-phase two-level voltage source converters connected in series to form a cascaded dc link. The suggested configuration is analyzed, and a method for dc-link midpoint voltage balancing is developed. Voltage balancing is based on the use of additional degrees of freedom that exist in multiphase machines and represents entirely new utilization of these degrees. The validity of the topology and its control is verified by simulation and experimental results on a laboratory-scale prototype, thus proving that it is possible to achieve satisfactory dc-link voltage control under various operating scenarios.
Enabling Italian E-Government through a Cooperative Architecture

The Italian approach to e-Government is based on the development and deployment of the Unitary Network, a “secure Intranet” interconnecting all the public administrations. The Cooperative Architecture, currently designed on top of it, is the reference distributed computing model in which each administration is represented as a Domain, exchanging data and application services with the others through Cooperative Gateways. Some issues have been, and currently need to be, addressed, such as the presence of legacy systems, the need of a cooperative development process, the identification of the more effective cooperative approaches. In this paper some first experimental projects carried out in the years 1998-2000, aiming at validating the Cooperative Architecture, will be described; then some lessons gained by these first experiences will be presented, leading to a proposal for a joint development process.
Microphone-Array Localization Error Estimation with Applicationto Sensor

This paper presents a means for predicting the error region associated with a speech-source location estimate obtained from a set of microphones in a room environment. The error predictor presented is derived assuming a speci c source-sensor geometry consisting of pairs of closely-spaced sensors for which a delay estimate associated with the potential source has been evaluated. The accuracy of the predictor is evaluated through a set of Monte Carlo simulations and an application of the predictor to microphone-array design in the context of a video-conferencing scenario is presented. PACS: 43.72 Michael S. Brandstein et al JASA submission 1
Initial Experience of a Digital Training Resource for Modified Rankin Scale Assessment in Clinical Trials

Background and Purpose— The modified Rankin Scale (mRS) is the preferred measure of disability in cerebrovascular clinical trials, but its value is restricted by interobserver variability. Poor reliability reduces the statistical power of clinical trials and leads to underestimation of effect size. Strategies to improve mRS grading are required. Video training has previously improved application of the National Institutes of Health Stroke Scale in clinical research. We developed an mRS training resource in an attempt to minimize interobserver variability. Methods— We produced a complete training resource comprising an instructional DVD with accompanying written materials and assessment recordings of patient interviews. Formal assessment of training involved grading of real-life cases. Results of initial training and recertification were collected centrally and scored. Results— Data from 1564 assessments are presented. The majority of assessors were participating in 2 large prospective clinical stroke trials. Assessors represented a mixed group of disciplines and nationalities. After training, most trainees (90%) achieved certification in mRS assessment. The majority (85%) of investigators who did not reach an acceptable score on initial testing achieved certification after further exposure to the package. Conclusions— Mass training in mRS assessment for clinical trials is possible. We outline the development of a video-based training package, including technical issues, patient selection procedures, and methods of scoring and assessment. Certification results suggest that use of the resource can improve mRS grading. Acceptability of the training has been demonstrated by its successful use in 2 international acute stroke trials, SAINT 1 and CHANT.
Geochemical and mineralogical indicators for aqueous processes in the Columbia Hills of Gusev crater, Mars

[1] Water played a major role in the formation and alteration of rocks and soils in the Columbia Hills. The extent of alteration ranges from moderate to extensive. Five distinct rock compositional classes were identified; the order for degree of alteration is Watchtower ≅ Clovis > Wishstone ≅ Peace > Backstay. The rover's wheels uncovered one unusual soil (Paso Robles) that is the most S-rich material encountered. Clovis class rocks have compositions similar to Gusev plains soil but with higher Mg, Cl, and Br and lower Ca and Zn; Watchtower and Wishstone classes have high Al, Ti, and P and low Cr and Ni; Peace has high Mg and S and low Al, Na, and K; Backstay basalts have high Na and K compared to plains Adirondack basalts; and Paso Robles soil has high S and P. Some rocks are corundum-normative, indicating that their primary compositions were changed by loss and/or gain of rock-forming elements. Clovis materials consist of magnetite, nanophase ferric-oxides (npOx), hematite, goethite, Ca-phosphates, Ca- and Mg-sulfates, pyroxene, and secondary aluminosilicates. Wishstone and Watchtower rocks consist of Fe-oxides/oxyhydroxides, ilmenite, Ca-phosphate, pyroxene, feldspar, Mg-sulfates, and secondary aluminosilicates. Peace consists of magnetite, npOx, Mg- and Ca-sulfates, pyroxene, olivine, feldspar, apatite, halides, and secondary aluminosilicates. Paso Robles consists of Fe3+-, Mg-, Ca-, and other sulfates, Ca-phosphates, hematite, halite, allophane, and amorphous silica. Columbia Hills outcrops and rocks may have formed by the aqueous alteration of basaltic rocks, volcaniclastic materials, and/or impact ejecta by solutions that were rich in acid-volatile elements.
Measurement automation and result processing in timing analysis of a Linux-based CAN-to-CAN gateway

The aim of this paper is to describe the method used to analyze timing properties of a Linux-based CAN-to-CAN gateway and to briefly present some of the analysis results. The considered gateway, implemented as an embedded system, can significantly simplify rapid prototyping of CAN-based distributed systems such as those used in automotive applications. The main interest was to measure the latencies induced by the gateway under the wide range of conditions such as various types of traffic, gateway configurations, additional system load and Linux kernel versions. The combinations of these conditions resulted in almost 400 different experiments and more than 600 graphs visualizing the results. A simple method to automate the experiments and to effectively draw conclusions from such a high number of experiments is proposed.
Using SOLO to Evaluate an Educational Virtual Environment in a Technology Education Setting

The present research investigates the contribution of an interactive educational virtual environment on milk pasteurization to the learning outcomes of 40 students in a technical secondary school using SOLO taxonomy. After the interaction with the virtual environment the majority of the students moved to higher hierarchical levels of understanding on the structure and operation of the pasteurization apparatus, the different paths and temperatures of fresh and pasteurized milk, hot and cold water, and the way heat is exchanged. The functional nature knowledge the students constructed, led them to develop physical nature knowledge, knowledge of the relationship between physical and functional nature, and finally process knowledge. The design of the three dimensional virtual environment, its content and the meaningful learning tasks are important for technology knowledge.
Occipital Nerve Blockade in Chronic Cluster Headache Patients and Functional Connectivity Between Trigeminal and Occipital Nerves

Headache syndromes often involve occipital and neck symptoms, suggesting a functional connectivity between nociceptive trigeminal and cervical afferents. Although reports regarding effective occipital nerve blockades in cluster headache exist, the reason for the improvement of the clinical symptoms is not known. Using occipital nerve blockade and nociceptive blink reflexes, we were able to demonstrate functional connectivity between trigeminal and occipital nerves in healthy volunteers. The R2 components of the nociceptive blink reflex and the clinical outcome in 15 chronic cluster headache patients were examined before and after unilateral nerve blockade of the greater occipital nerve with 5 ml prilocain (1%) on the headache side. In contrast to recent placebo-controlled studies, only nine of the 15 cluster patients reported some minor improvement in their headache. Six patients did not report any clinical change. Exclusively on the injection side, the R2 response areas decreased and R2 latencies increased significantly after the nerve blockade. These neurophysiological and clinical data provide further evidence for functional connectivity between cervical and trigeminal nerves in humans. The trigeminocervical complex does not seem to be primarily facilitated in cluster headache, suggesting a more centrally located pathology of the disease. However, the significant changes of trigeminal function as a consequence of inhibition of the greater occipital nerve were not mirrored by a significant clinical effect, suggesting that the clinical improvement of occipital nerve blockades is not due to a direct inhibitory effect on trigeminal transmission.
A Comparison Between Malay and English Research Article Discussions

This study investigated the rhetorical organization of Malay and English research article discussions. A move analysis was carried out for the two sets of data of the present study based on a modified version of Peacock’s model for the discussion section. For this purpose, a total of 40 research article discussions restricted to empirical studies (20 from each corpus) were randomly selected from journals in the field of education. Results show that Malay discussions are more context dependent while English discussions are more context independent and standalone. In addition, compared with its English-language counterparts, the fit between Peacock’s model and Malay discussions is partial. This phenomenon may be due to the preference for rhetorical concepts and values in the local writing community. The findings have pedagogical implications in an English for Academic Purposes classroom.
A role for the Golgi matrix protein giantin in ciliogenesis through control of the localization of dynein-2

Summary The correct formation of primary cilia is central to the development and function of nearly all cells and tissues. Cilia grow from the mother centriole by extension of a microtubule core, the axoneme, which is then surrounded with a specialized ciliary membrane that is continuous with the plasma membrane. Intraflagellar transport moves particles along the length of the axoneme to direct assembly of the cilium and is also required for proper cilia function. The microtubule motor, cytoplasmic dynein-2 mediates retrograde transport along the axoneme from the tip to the base; dynein-2 is also required for some aspects of cilia formation. In most cells, the Golgi lies adjacent to the centrioles and key components of the cilia machinery localize to this organelle. Golgi-localized proteins have also been implicated in ciliogenesis and in intraflagellar transport. Here, we show that the transmembrane Golgi matrix protein giantin (GOLGB1) is required for ciliogenesis. We show that giantin is not required for the Rab11–Rabin8–Rab8 pathway that has been implicated in the early stages of ciliary membrane formation. Instead we find that suppression of giantin results in mis-localization of WDR34, the intermediate chain of dynein-2. Highly effective depletion of giantin or WDR34 leads to an inability of cells to form primary cilia. Partial depletion of giantin or of WDR34 leads to an increase in cilia length consistent with the concept that giantin acts through dynein-2. Our data implicate giantin in ciliogenesis through control of dynein-2 localization.