Miracle-dz/UniFAR-FTUs huggingface dataset:
Parallelizable Sampling of Markov Random Fields

Markov Random Fields (MRFs) are an important class of probabilistic models which are used for density estimation, classification, denoising, and for constructing Deep Belief Networks. Every application of an MRF requires addressing its inference problem, which can be done using deterministic inference methods or using stochastic Markov Chain Monte Carlo methods. In this paper we introduce a new Markov Chain transition operator that updates all the variables of a pairwise MRF in parallel by using auxiliary Gaussian variables. The proposed MCMC operator is extremely simple to implement and to parallelize. This is achieved by a formal equivalence result between arbitrary pairwise MRFs and a particular type of Restricted Boltzmann Machine. This result also implies that the later can be learned in place of the former without any loss of modeling power, a possibility we explore in experiments.
Endoscopic Transsphenoidal Pituitary Surgery with Intraoperative Magnetic Resonance Imaging

OBJECTIVE: The two most recent significant advances in pituitary surgery have been the endonasal endoscopic approach and intraoperative magnetic resonance imaging (IMRI). Each provides improved visualization of intra- and parasellar anatomy with the goal of attaining a complete resection. The combination of the two techniques has not been previously reported in the literature. METHODS: We performed endoscopic, endonasal resection of pituitary macroadenomas in 15 patients using the Polestar N-10 (0.12T) IMRI (Odin Medical Technologies, Inc., Newton, MA). Eleven patients had nonfunctioning tumors, three had acromegaly, and one had a medication-resistant prolactinoma. The effect of the magnetic field on the cathode ray tube screen and the image quality of the IMRI images were assessed. The presence of residual tumor on IMRI was noted and then re-examined with the endoscope. RESULTS: Although the Polestar N-10 is a low Tesla magnet, the IMRI caused significant distortion of the cathode ray tube screen regardless of the viewing angle. This was overcome with the use of a wall-mounted plasma screen. IMRI images were obtained in all cases and were of sufficiently high quality to demonstrate adequate decompression of the optic chiasm and the removal of all suprasellar tumor. In three cases, residual tumor was found with IMRI that was resected endoscopically before the completion of surgery. In four other cases, potential residual tumor was examined endoscopically and found to be normal postoperative change. In eight cases no residual intrasellar tumor was seen on the IMRI. Preresection visual deficits improved in all cases and the insulin-like growth factor levels normalized in two of three cases. There were no delayed cerebrospinal fluid leaks. CONCLUSION: Combining intraoperative endoscopy and IMRI is feasible and distortion of the cathode ray tube screen can be overcome with the use of either a plasma or liquid crystal display screen. Each technology provides complementary information, which can assist the surgeon in safely maximizing the extent of resection. In this small series using a low-field magnet, rates of residual tumor following endoscopic transsphenoidal surgery were less than have been reported following microscope-based transsphenoidal surgery.
How can the study of physiological reactivity contribute to our understanding of adversity and resilience processes in development?

Abstract The focus of this article is to present current progress in understanding the interplay among adversity, physiological sensitivity to context, and adaptive functioning, with an emphasis on implications and future directions for resilience researchers. It includes a review of current literature that demonstrates (a) links between various levels of adversity exposure and variability in physiological reactivity, (b) how the interplay between children's physiological reactivity and different sources of risk and adversity relates to variability in adaptive functioning, and (c) various approaches for capturing a more dynamic nature of physiological reactivity and related processes. Throughout, important conceptual and empirical issues are highlighted.
Derivational Morphological Analysis as a Strategy for Vocabulary Acquisition in Spanish

Although first language (L1) and second language (L2) research has indicated that the meanings of unknown words can be derived from the contexts in which they occur, research has also found limitations to the value of context. Using data gathered in a classroom experiment on L2 vocabulary acquisition (Frantzen, 1998), the present study sought to determine some of the reasons why the context in which a word appears does not always lead a language learner to an accurate interpretation of its meaning. It expands the existing research by using a natural, intact, unmanipulated text as the context (an aspect underrepresented in current L2 word inferencing literature). Analysis of the students’ answers, their self–reported guessing strategies, the contexts in which the words appeared, and the text's glossing revealed that the “blame” for the incorrect answers may be placed on: (a) the context itself, (b) the students’ behavior, and in a minor way (c) the story's glossing. Numerous patterns are presented and discussed in light of other L1 and L2 research and new patterns are reported.
High-dose therapy and autologous stem-cell transplantation versus conventional therapy for patients with advanced Hodgkin's lymphoma responding to front-line therapy.

PURPOSE To determine whether high-dose therapy (HDT) with autologous stem-cell transplantation (ASCT) should be included in the initial consolidative treatment of patients with advanced, unfavorable Hodgkin's lymphoma (HL). PATIENTS AND METHODS One hundred sixty-three patients achieving complete remission (CR) or partial remission (PR) with four initial courses of doxorubicin, bleomycin, vinblastine, and dacarbazine, or other doxorubicin-containing regimens, were randomly assigned to receive HDT plus ASCT (83 patients) versus four courses of conventional chemotherapy (80 patients). Unfavorable HL was defined as the presence of at least two of the following poor prognostic factors: high lactate dehydrogenase level, large mediastinal mass (greater than at least 33% of the thoracic diameter), more than one extranodal site, low hematocrit level, and inguinal involvement. RESULTS At the end of the treatment program, 92% of patients in arm A and 89% in arm B achieved a CR (P =.6). After a median follow-up of 48 months, the 5-year failure-free survival rates were 75% (95% confidence interval [CI], 65 to 85) in arm A and 82% (95% CI, 73 to 90) in arm B (P =.4). The 5-year overall survival rates were 88% (95% CI, 80 to 96) in arm A and 88% (95% CI, 79 to 96) in arm B (P =.99). The 5-year relapse-free survival rates were 88% in arm A (95% CI, 80 to 96) and 94% in arm B (95% CI, 88 to 100), and the difference was not significant (P =.3). CONCLUSION Patients with advanced unfavorable HL achieving CR or PR after four courses of doxorubicin-containing regimens have a favorable outcome with conventional chemotherapy. No benefit from an early intensification with HDT and ASCT was shown.
Animal Health and Welfare Issues Facing Organic Production Systems

Simple Summary The demand for organically grown, animal derived produce is increasing due to a growing desire for consumer products that have minimal chemical inputs and high animal welfare standards. Evaluation of the scientific literature suggests that a major challenge facing organic animal production systems is the management and treatment of health-related issues. However, implementation of effective management practices can help organic animal producers achieve and maintain high standards of health and welfare, which is necessary to assure consumers that organic animal-based food and fibre has not only been produced with minimal or no chemical input, but under high standards of animal welfare. Abstract The demand for organically-grown produce is increasing worldwide, with one of the drivers being an expectation among consumers that animals have been farmed to a high standard of animal welfare. This review evaluates whether this expectation is in fact being met, by describing the current level of science-based knowledge of animal health and welfare in organic systems. The primary welfare risk in organic production systems appears to be related to animal health. Organic farms use a combination of management practices, alternative and complementary remedies and convenional medicines to manage the health of their animals and in many cases these are at least as effective as management practices employed by non-organic producers. However, in contrast to non-organic systems, there is still a lack of scientifically evaluated, organically acceptable therapeutic treatments that organic animal producers can use when current management practices are not sufficient to maintain the health of their animals. The development of such treatments are necessary to assure consumers that organic animal-based food and fibre has not only been produced with minimal or no chemical input, but under high standards of animal welfare.
Personality disorders in patients in a day-treatment programme for eating disorders

The present study examined the prevalence of DSM-III-R personality disorders (PDs) and levels of depressive symptoms in patients in a day-hospital programme for eating disorders. Sixty-five patients diagnosed with anorexia nervosa and bulimia nervosa were administered the Personality Diagnostic Questionnaire Revised (PDQ-R), the Eating Disorder Inventory (EDI) and the Beck Depression Inventory (BDI). In total, 49.2 per cent of all patients had at least one PD diagnosis. No significant difference was found between patients with bulimia nervosa and anorexia nervosa. Eating Disorder patients with at least one PD had higher scores on the BDI and three EDI subscales compared to patients without a PD. In general, the prevalence of Personality Disorders in the present sample tended to be closer to results quoted by studies with eating-disordered outpatients rather than inpatients. Axis I disorders may affect personality state measures. Copyright (C) 2000 John Wiley and Sons, Ltd and Eating Disorders Association.
Mean platelet volume is increased in hyperthyroidism

In 28 unselected patients with hyperthyroidlsm, platelet count, platelet hematocrft, mean platelet volume, and platelet distribution width were measured at the time of presentation and again when the patients were euthyroid. On return to the euthyroid state, there were highly significant falls in the mean values of the mean platelet volume (16% decline, P < 0.001) and the platelet hematocrit (16% decline, P < 0.001) and a slight but highly significant increase in the mean value of the platelet distribution width (2% increase, P < 0.01). A decline in mean platelet volume was observed in 24 of 28 patients (86%); three patients showed no change. There was no significant change in the mean value of the platelet count. The observed effects of thyrotoxicosis on platets appeared to be largely independent of the well‐known effects on erythrocytes and white blood cells. An increase in mean platelet volume is a regular feature of hyperthyroidism that has not previously been described.
Reliability of the Emotion-Related Parenting Styles Scale Across Gender and Parent Status Groups

Research Findings: Emotional and social competence are critical to a child’s current and future well-being. A. D. Paterson et al. (2012) studied a sample of mothers and proposed that an adult’s approach to the socialization of a child’s emotions can be summarized in his or her parenting style as measured by the Emotion-Related Parenting Styles (ERPS) scale. These styles are emotion approving, emotion disapproving, active socialization, and uncertain/ineffective socialization of negative emotions. This study aimed to determine whether the ERPS scale is a reliable measure of the emotion socialization styles of parents and non-parents of both genders. Participants were 521 undergraduate students—males (n = 76), females (n = 445), parents (n = 290), non-parents (n = 231)—with a mean age of 32.26 years (SD = 9.92, range = 18–61 years). There were no significant differences between the ERPS subscale scores of parents and non-parents, but males and younger adults showed higher disapproving and uncertain responses. The factor structure of the ERPS was confirmed for females. One factor was found to be unreliable for males. Practice or Policy: The ERPS is a reliable measure of the emotion socialization styles of females. Further research is required to establish the scale’s reliability with males.
Bounds on the Bethe Free Energy for Gaussian Networks

We address the problem of computing approximate marginals in Gaussian probabilistic models by using mean field and fractional Bethe approximations. As an extension of Welling and Teh (2001), we define the Gaussian fractional Bethe free energy in terms of the moment parameters of the approximate marginals and derive an upper and lower bound for it. We give necessary conditions for the Gaussian fractional Bethe free energies to be bounded from below. It turns out that the bounding condition is the same as the pairwise normalizability condition derived by Malioutov et al. (2006) as a sufficient condition for the convergence of the message passing algorithm. By giving a counterexample, we disprove the conjecture in Welling and Teh (2001): even when the Bethe free energy is not bounded from below, it can possess a local minimum to which the minimization algorithms can converge.
Functional Characterization of Caenorhabditis elegans Heteromeric Amino Acid Transporters*

Mammalian heteromeric amino acid transporters (HATs) are composed of a multi-transmembrane spanning catalytic protein covalently associated with a type II glycoprotein (e.g. 4F2hc, rBAT) through a disulfide bond. Caenorhabditis elegans has nine genes encoding close homologues of the HAT catalytic proteins. Three of these genes (designated AAT-1 to AAT-3) have a much higher degree of similarity to the mammalian homologues than the other six, including the presence of a cysteine residue at the position known to form a disulfide bridge to the glycoprotein partner in mammalian HATs. C. elegans also has two genes encoding homologues of the heteromeric amino acid transporter type II glycoprotein subunits (designated ATG-1 and ATG-2). Both ATG, and/or AAT-1, -2, -3 proteins were expressed in Xenopus oocytes and tested for amino acid transport function. This screen revealed that AAT-1 and AAT-3 facilitate amino acid transport when expressed together with ATG-2 but not with ATG-1 or the mammalian type II glycoproteins 4F2hc and rBAT. AAT-1 and AAT-3 covalently bind to both C. elegans ATG glycoproteins, but only the pairs with ATG-2 traffic to the oocyte surface. Both of these functional, surface-expressed C. elegans HATs transport most neutral amino acids and display the highest transport rate for l-Ala and l-Ser (apparent Km 100 μm range). Similar to their mammalian counterparts, the C. elegans HATs function as (near) obligatory amino acid exchangers. Taken together, this study demonstrates that the heteromeric structure and the amino acid exchange function of HATs have been conserved throughout the evolution of nematodes to mammals.
Anomalous Systemic Arterial Supply to Normal Basal Segments of Left Lower Lobe: Characteristic Imaging Findings

Purpose The purpose of this study was to describe the characteristic findings in each imaging modality of anomalous systemic arterial supply to normal basal segments of the left lower lobe of the lung. Method Five patients with anomalous systemic arterial supply to normal basal segments of the left lower lobe were retrospectively reviewed. Chest radiography, contrast-enhanced CT scan, angiography, and other imaging modalities were analyzed. Results The imaging findings of this anomaly were characterized by three issues as follows: an anomalous systemic artery arising from the thoracic aorta, absence of pulmonary arterial supply, and normal bronchial system as well as normal pulmonary parenchyma in the affected segments. The anomalous systemic artery was demonstrated on chest radiography, contrast-enhanced CT scan, MRI, and thoracic aortography. Absence of pulmonary arterial supply was revealed by pulmonary angiography, radiolabeled perfusion scan, and CT scan. Normal bronchial system was confirmed by radiolabeled ventilation scan, bronchography, and CT scan. Conclusion CT is useful in making the correct diagnosis of this anomaly because it is the only diagnostic method that can demonstrate the anomalous systemic artery, absence of pulmonary arterial supply, and normal bronchial system in the affected segments.
Impact of Ocean Acidification on Energy Metabolism of Oyster, Crassostrea gigas—Changes in Metabolic Pathways and Thermal Response

Climate change with increasing temperature and ocean acidification (OA) poses risks for marine ecosystems. According to Pörtner and Farrell [1], synergistic effects of elevated temperature and CO2-induced OA on energy metabolism will narrow the thermal tolerance window of marine ectothermal animals. To test this hypothesis, we investigated the effect of an acute temperature rise on energy metabolism of the oyster, Crassostrea gigas chronically exposed to elevated CO2 levels (partial pressure of CO2 in the seawater ~0.15 kPa, seawater pH ~ 7.7). Within one month of incubation at elevated Pco2 and 15 °C hemolymph pH fell (pHe = 7.1 ± 0.2 (CO2-group) vs. 7.6 ± 0.1 (control)) and Peco2 values in hemolymph increased (0.5 ± 0.2 kPa (CO2-group) vs. 0.2 ± 0.04 kPa (control)). Slightly but significantly elevated bicarbonate concentrations in the hemolymph of CO2-incubated oysters ([HCO− 3]e = 1.8 ± 0.3 mM (CO2-group) vs. 1.3 ± 0.1 mM (control)) indicate only minimal regulation of extracellular acid-base status. At the acclimation temperature of 15 °C the OA-induced decrease in pHe did not lead to metabolic depression in oysters as standard metabolism rates (SMR) of CO2-exposed oysters were similar to controls. Upon acute warming SMR rose in both groups, but displayed a stronger increase in the CO2-incubated group. Investigation in isolated gill cells revealed a similar temperaturedependence of respiration between groups. Furthermore, the fraction of cellular energy demand for ion regulation via Na+/K+-ATPase was not affected by chronic hypercapnia or temperature. Metabolic profiling using 1H-NMR spectroscopy revealed substantial changes in some tissues following OA exposure at 15 °C. In mantle tissue alanine and ATP levels decreased significantly whereas an increase in succinate levels was observed in gill tissue. These findings suggest shifts in metabolic pathways following OA-exposure. Our study confirms that OA affects energy metabolism in oysters and suggests that climate change may affect populations of sessile coastal invertebrates such as mollusks.
From Transition To Transitioning: An Anthropological Study of Female To Male Transsexuality

This thesis explores Female To Male processes of transition through ethnographic and qualitative data gathered during fieldwork in the trans community in London, and through critical engagement with existing discourses of trans sexuality. Despite the greater visibility of Male to Female transsexuality in academic texts and popular culture, FTM transition remains largely under theorised. This research is an anthropological contribution to this field, as well as to current developments in social anthropology and the anthropology of gender. Transition has been traditionally theorised through the sex/gender distinction, where sex and gender hold different ontological and political values, and it is understood as the passage from 'female' to 'male' in terms of the intersection of a series of biological, psychological, social and legal changes. Even though recent discourses of sexuality have pointed out the limitations of this paradigm, they still reinforce universal models of the relation between sex and gender and abstract categories such as subjectivity, time and experience. However, my informants understood that their transitions were complex and unique, and that their experience of transitioning was not necessarily exclusively about sex/gender. They described their experiences of transition in very different ways, where hormones, surgery and other transitional technologies were not mechanistic agents in their processes, but part of particular assemblages through which change, continuity and time are brought into experience through becoming 'FTM'. Therefore, in this thesis FTM is understood as a particular kind of becoming rather than the passage between static categories. In the first part of the thesis I explore existing ways of conceptualising transsexuality and transition through a series of theoretical, medical and political' coordinates'. I focus on how the emergence of protocols of clinical management of transsexuality were grounded in the distinction between sex and gender, and unpack some of the ways in which this distinction informed the emergence of political discourses of sexuality and sexual formation through which trans people in Britain construct their individual and collective identities. In the second part I explore three subjects privileged by the participants in my primary research: testosterone, narrative and thresholds. I argue that these domains both reproduce categories and the language of linear passage and demand a different analytic approach. Each chapter explicates 'FTM' by exploring different kinds, scales and temporalities of experience, as well as the kinds, scales and temporalities of the relations between them.
A 17.5-to-20.94GHz and 35-to-41.88GHz PLL in 65nm CMOS for wireless HD applications

This work shows a complete PLL that is integrated in standard industrial 65nm CMOS technology. This frequency synthesizer is fully compliant with IEEE 802.15. 3c normalization [1–4]. This PLL delivers a quadrature LO signal around 20GHz and a differential LO signal around 40GHz and has 17.9% tuning range. The wide tuning range of 17.9% permits to cover the full IEEE 802.15. 3c band with industrial margin. The phase noise is −100dBc/Hz at 1MHz offset and the total power dissipation is only 80mW including the output buffers and amplifiers. Short-range wireless multi-Gb/sec communication systems use the mm-wave band of 57GHz to 66GHz, according to the IEEE 802.15. 3c normalization. The frequency synthesis is one of the key elements for these transceivers. Indeed, one must take into account the antagonist tradeoff between large band tuning range of the frequency synthesizer and phase noise performance. In transceivers using super-heterodyne architecture with double conversion, the frequency synthesizer signal fLO can be equal to 2fRF /3 and fRF /3. In this case, to cover the four channels of the IEEE 802.15. 3c normalization, the frequency synthesizer has to deliver a first local oscillator (LO) signal between 19.44GHz and 21.6GHz and a second LO signal between 38.88GHz and 43.2GHz, respectively. This architecture offers a good trade off between the required large frequency tuning range (≫15%) and low phase noise (≪−95dBc/Hz).
The management of gastric polyps

Background Gastric polyps are important as some have malignant potential. If such polyps are left untreated, gastric cancer may result. The malignant potential depends on the histological type of the polyp. The literature base is relatively weak and any recommendations made must be viewed in light of this. Definition Gastric polyps are sessile or pedunculated lesions that originate in the gastric epithelium or submucosa and protrude into the stomach lumen. Malignant potential Depending on histological type, some gastric polyps (adenomas and hyperplastic polyps) have malignant potential and are precursors of early gastric cancer. They may also indicate an increased risk of intestinal or extra-intestinal malignancy.