Miracle-dz/UniFAR-FTUs huggingface dataset:
Shallow circuits with high-powered inputs

A polynomial identity testing algorithm must determine whether an input polynomial (given for instance by an arithmetic circuit) is identically equal to 0. In this paper, we show that a deterministic black-box identity testing algorithm for (high-degree) univariate polynomials would imply a lower bound on the arithmetic complexity of the permanent. The lower bounds that are known to follow from derandomization of (low-degree) multivariate identity testing are weaker. To obtain a lower bound for the permanent it would be su-cient to derandomize identity testing for polynomials of a very speciflc norm: sums of products of sparse polynomials with sparse coe-cients. This observation leads to new versions of the Shub-Smale ? -conjecture on integer roots of univariate polynomials. In particular, we show that a lower bound for the permanent would follow if one could give a polynomial upper bound on the number of real roots of sums of products of sparse polynomials (Descartes' rule of signs gives such a bound for sparse polynomials and products thereof). In fact the same lower bound would follow even if one could only prove a slightly superpolynomial upper bound on the number of real roots. This is a consequence of a new result on reduction to depth 4 for arithmetic circuits which we establish in a companion paper. We also show that an even weaker bound on the number of real roots would su-ce to obtain a lower bound on the size of depth 4 circuits computing the permanent. These results suggest the intriguing possibility that tools from real analysis might be brought to bear on a longstanding open problem: what is the arithmetic complexity of the permanent polynomial?
Efferocytosis and Outside-In Signaling by Cardiac Phagocytes. Links to Repair, Cellular Programming, and Intercellular Crosstalk in Heart

Phagocytic sensing and engulfment of dying cells and extracellular bodies initiate an intracellular signaling cascade within the phagocyte that can polarize cellular function and promote communication with neighboring non-phagocytes. Accumulating evidence links phagocytic signaling in the heart to cardiac development, adult myocardial homeostasis, and the resolution of cardiac inflammation of infectious, ischemic, and aging-associated etiology. Phagocytic clearance in the heart may be carried out by professional phagocytes, such as macrophages, and non-professional cells, including myofibrolasts and potentially epithelial cells. During cardiac development, phagocytosis initiates growth cues for early cardiac morphogenesis. In diseases of aging, including myocardial infarction, heightened levels of cell death require efficient phagocytic debridement to salvage further loss of terminally differentiated adult cardiomyocytes. Additional risk factors, including insulin resistance and other systemic risk factors, contribute to inefficient phagocytosis, altered phagocytic signaling, and delayed cardiac inflammation resolution. Under such conditions, inflammatory presentation of myocardial antigen may lead to autoimmunity and even possible rejection of transplanted heart allografts. Increased understanding of these basic mechanisms offers therapeutic opportunities.
Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP)-mediated Calcium Signaling and Arrhythmias in the Heart Evoked by β-Adrenergic Stimulation*♦

Background: Initial studies on cardiac NAADP signaling were published, but no role for NAADP in cardiac arrhythmias has been reported. Results: NAADP affects spontaneous diastolic Ca2+ transients in cardiac myocytes and arrhythmias in awake mice. Conclusion: Results indicate a pivotal role for NAADP in fine-tuning of cardiac excitation-contraction coupling. Significance: First evidence is reported for involvement of NAADP in cardiac arrhythmias evoked by β-adrenergic stimulation. Nicotinic acid adenine dinucleotide phosphate (NAADP) is the most potent Ca2+-releasing second messenger known to date. Here, we report a new role for NAADP in arrhythmogenic Ca2+ release in cardiac myocytes evoked by β-adrenergic stimulation. Infusion of NAADP into intact cardiac myocytes induced global Ca2+ signals sensitive to inhibitors of both acidic Ca2+ stores and ryanodine receptors and to NAADP antagonist BZ194. Furthermore, in electrically paced cardiac myocytes BZ194 blocked spontaneous diastolic Ca2+ transients caused by high concentrations of the β-adrenergic agonist isoproterenol. Ca2+ transients were recorded both as increases of the free cytosolic Ca2+ concentration and as decreases of the sarcoplasmic luminal Ca2+ concentration. Importantly, NAADP antagonist BZ194 largely ameliorated isoproterenol-induced arrhythmias in awake mice. We provide strong evidence that NAADP-mediated modulation of couplon activity plays a role for triggering spontaneous diastolic Ca2+ transients in isolated cardiac myocytes and arrhythmias in the intact animal. Thus, NAADP signaling appears an attractive novel target for antiarrhythmic therapy.
Digital multi-carrier spread spectrum versus direct sequence spread spectrum for resistance to jamming and multipath

We compare single user digital multi-carrier spread spectrum (MC-SS) modulation with direct sequence (DS) SS (with a modified implementation) in the presence of narrowband interference (NBI) and multipath fading. We derive closed-form expressions for the symbol error probability for both the linear MMSE receiver as well as the conventional matched-filter receiver under different scenarios: additive white Gaussian noise (AWGN) channel with NBI, multipath channel with or without NBI. We show that DS-SS can achieve the same performance as MC-SS if the spreading code is carefully designed to have perfect periodic autocorrelation function (PACF). On the other hand, MC-SS is more robust to narrowband interference and multipath fading than is DS-SS with the widely used spreading codes that do not possess perfect PACE. Our analysis reveals that the performance improvement of MC-SS is precisely due to the implicit construction of an equivalent spreading code having nonconstant amplitude but possessing perfect periodic autocorrelation.
N′-(3-Bromo-5-chloro-2-hydroxybenzylidene)-4-hydroxybenzohydrazide

The molecule of the title compound, C14H10BrClN2O3, is planar [dihedral angle between the aromatic rings = 3.0 (2)°] and shows a trans configuration with respect to the C=N double bond. The crystal structure is stabilized by intermolecular N—H⋯O hydrogen bonds and an intramolecular O—H⋯N interaction also occurs.
KINETICS OF HEAVY METAL IONS REMOVAL BY USE OF NATURAL ZEOLITE

ABSTRACT Kinetics of the uptake of cadmium, lead, copper, nickel and zinc ions from single ion solutions and from their mixture by zeolitic rock has been studied. Removal of ions obeyed the kinetic equation for adsorption. Corresponding adsorption constants and distribution coefficients were determined for each metal ion uptake from single ion solution or mixture. An attempt was made to explain zeolite selectivity to different metal ions and the influence of water hardness on the uptake in terms of metal ionic radii and enthalpy of hydration. It was found that lead ions were strongly immobilized by the zeolite investigated, both from single ion and mixed solutions, as well as from soft and hard water.
Observational evidence for expansion in the SSS spectra of novae

For several novae, a bright X-ray source with a spectrum resembling the class of Super Soft X-ray Sources (SSS) has been observed a few weeks to months after outburst. Novae are powered by explosive nuclear burning on the surface of a white dwarf, and enough energy is produced to power a radiatively driven wind. Owing to the evolution of the opacity of the ejecta, the observable spectrum gradually shifts from optical to soft X-rays (SSS phase). It has sometimes been assumed that at the beginning of the SSS phase no more mass loss occurs. However, high-resolution X-ray spectra of some novae have shown highly blue-shifted absorption lines, indicating a significant expansion. In this paper, I show that all novae that have been observed with X-ray gratings during their SSS phase show significant blue shifts. I argue that all models that attempt to explain the X-ray bright SSS phase have to accommodate the continued expansion of the ejecta (© 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)
In vitro effect of murine-derived transfer factor on Salmonella-specific rosette formation

The splenic lymphocytes from Salmonella-immune ICR Swiss or C3H/HeJ mice formed greater than 0.2% antigen-specific rosettes with sheep erythrocytes coated with a spent-medium protein antigen of Salmonella typhimurium. These rosette-forming lymphocytes were found to be sensitive to the effects of antithymocyte serum plus complement. Transfer factor prepared from the Salmonella-immune splenic lymphocytes of ICR Swiss mice was active in sensitizing nonimmune ICR Swiss or C3H/HeJ lymphocytes to form greater than or equal to 0.2% rosettes with salmonella antigen-coated sheep erythrocytes. These rosettes were also sensitive to antithymocyte serum and complement. Few rosettes were formed between the transfer factor-treated lymphocytes and sheep erythrocytes coated with a Listeria protein antigen. A nonimmune dialysate preparation was inactive in sensitizing nonimmune lymphocytes, as indicated by a lack of rosette formation. Neither the immune transfer factor nor the nonimmune dialysate had any enhancing or abrogating effect upon rosette formation by splenic lymphocytes from Salmonella-immune mice. The enumeration of antigen-specific rosettes may be a useful means of assaying for transfer factor activity.
Quantitive aspects of glucose and glutamine metabolism by intestinal cells

Gut fuel utilisation has several unique features. Arterial and luminal fuels provide nutrition for the enterocyte, the former being of more importance. This factor, and the heterogeneity of cell types within the gut makes it difficult to define its fuel utilisation. Metabolic control logic suggests that modulation of the maximal activity of any pathway resides in those enzymes that operate in vivo at rates far below their maximal capacity and that catalyse non-equilibrium reactions. On this basis, although enterocyte hexokinase activity is much higher than in other 'glycolytic' cells (for example, brain), potentially high rates of glucose utilisation are modulated by substrate cycling of glucose 6-phosphate back to glucose through glucose 6-phosphatase. Gluta-mine metabolism proceeds by glutaminase to produce glutamate, which may then be transaminated (aspartate-aminotrans-ferase and alanine-amino transferase) to produce a-ketoglutarate, alanine, and aspartate. The end products of glutamine metabolism by incubated gut preparations in vitro (mainly alanine), suggests that enterocytes, not immune cells, are responsible for most gut glutamine metabolism. High flux rates of glucose and glutamine metabolism in the enterocyte may result from the need for de novo synthesis of purines and pyrimidines and ribose sugars for nucleic acid synthesis. Sepsis reduces rates of glucose and glutamine metabolism, perhaps to preserve the increased consumption of these fuels by activated lymphocytes and macrophages in the gut wall. (Gut 1994; supplement 1: S 1 3-S 17)
Low-dose radioactive endovascular stents prevent smooth muscle cell proliferation and neointimal hyperplasia in rabbits.

BACKGROUND Restenosis induced by smooth muscle cell (SMC) migration and proliferation and neointimal thickening limits the clinical success of balloon angioplasty and stent implantation. In this study, the long-term effect of endovascular irradiation via low-dose radioactive stents on neointima formation was compared with conventional stent implantation in a rabbit model. METHODS AND RESULTS Palmaz-Schatz stents were made radioactive in a cyclotron. The stents had a very low activity (maximum, 35 microCi), and thus, manipulation did not require extensive radiation protection. One, 4, 12, and 52 weeks after the implantation of nonradioactive stents and radioactive stents in rabbit iliac arteries, neointimal thickening was analyzed by quantitative histomorphometry. Immunostaining for endothelial cell von Willebrand factor, macrophages, SMC alpha-actin, collagen type I, and proliferating cell nuclear antigen (PCNA) was performed to determine radiation-induced changes in the arterial wall. SMC proliferation was quantified by computer-assisted cell counting of PCNA-immunoreactive cells. Neointima formation was markedly suppressed by the implantation of radioactive stents in a dose-dependent fashion at all observed time points. At peak proliferative activity of SMCs 1 week after nonradioactive stent implantation, 30 +/- 2% of SMCs in the neointima were proliferating, compared with 0.5 +/- 0.1% of SMCs after implantation of stents with an initial activity of 35 microCi (P < .001). The neointima covering radioactive stents was characterized by decreased smooth muscle cellularity and increased extracellular matrix formation. Further, we observed a delayed endothelialization depending on the radiation dose. No difference in vascular thrombosis was found after nonradioactive and radioactive stent implantation. CONCLUSIONS The results of this study clearly indicate that low-dose radioactive endovascular stents potently inhibit SMC proliferation and neointimal hyperplasia in rabbits.
TOA location estimation based on cognitive radio channel occupancy prediction

Spectrum, environment and location awareness capabilities play a vital role in the autonomous and adaptive characteristics of cognitive radio. Knowledge of a cognitive radio (CR) user's location and type of environment may enhance optimisation of dynamic spectrum management and channel allocation. In this paper, a method for determining the near future location of a secondary user (SU) in a CR network, is proposed. This method incorporates a Time-of Arrival (TOA) location estimation algorithm with a Hidden Markhov Model (HMM) based channel occupancy prediction model. Using this method, location estimation under various channel conditions and for a range of available channel bandwidths, is investigated. Results indicate that non-line-of-sight conditions have a profoundly negative effect on location estimation accuracy, but that employing multiple future bandwidths as opposed to a single set of instantaneous bandwidths, does improve the situation, i.e. an average relative improvement in positional accuracy of 27%.
Reconstruction of Populations by Age, Sex and Level of Educational Attainment for 170 Countries for 1970-2010 Using Demographic Back-Projection Methods

Using demographic multi-state methods for back projecting the populations of 120 countries by age, sex and level of educational attainment from 2000 to 1970 (covering 93 percent of the 2000 world population), this paper presents an ambitious effort to reconstruct human capital data which are essential for empirically studying the aggregate level returns to education. Unlike earlier reconstruction efforts, this new dataset jointly produced at the International Institute for Applied Systems Analysis (IIASA) and the Vienna Institute of Demography (VID) gives the full educational attainment distributions for four categories (no education, primary, secondary and tertiary education) by five-year age groups and with definitions that are strictly comparable across time. Based on empirical distributions of educational attainment by age and sex for the year 2000, the method moves backward along cohort lines while explicitly considering the fact that men and women with different education have different levels of mortality. The resulting dataset will allow new estimates on the impact of agespecific human capital growth on economic growth and first results show—unlike earlier studies—a consistently positive effect. ∗ Wolfgang Lutz (author for correspondence), World Population Program, International Institute for Applied Systems Analysis (IIASA), Schlossplatz 1, 2361 Laxenburg, Austria and Vienna Institute of Demography, Austrian Academy of Sciences, Vienna, Austria. Email: lutz@iiasa.ac. at Anne Goujon, Vienna Institute of Demography, Austrian Academy of Sciences, Vienna, Austria and World Population Program, International Institute for Applied Systems Analysis (IIASA), Laxenburg, Austria. Samir K.C. , World Population Program, International Institute for Applied Systems Analysis (IIASA), Laxenburg, Austria. Warren Sanderson, Departments of Economics and History, State University of New York at Stony Brook, USA and World Population Program, International Institute for Applied Systems Analysis (IIASA), Laxenburg, Austria. DOI: 10.1553/populationyearbook2007s193 Reconstruction of populations by age, sex and level of educational attainment 194
Antimicrobial and Antiproliferative Potential of Anadenanthera colubrina (Vell.) Brenan

The aim of the present study was to perform an in vitro analysis of the antimicrobial and antiproliferative potential of an extract from Anadenanthera colubrina (Vell.) Brenan (angico) and chemically characterize the crude extract. Antimicrobial action was evaluated based on the minimum inhibitory concentration (MIC), minimum bactericidal/fungicidal concentration, and the inhibition of formation to oral biofilm. Cell morphology was determined through scanning electron microscopy (SEM). Six strains of tumor cells were used for the determination of antiproliferative potential. The extract demonstrated strong antifungal activity against Candida albicans ATCC 18804 (MIC = 0.031 mg/mL), with similar activity found regarding the ethyl acetate fraction. The extract and active fraction also demonstrated the capacity to inhibit the formation of Candida albicans to oral biofilm after 48 hours, with median values equal to or greater than the control group, but the difference did not achieve statistical significance (P > 0.05). SEM revealed alterations in the cell morphology of the yeast. Regarding antiproliferative activity, the extract demonstrated cytostatic potential in all strains tested. The present findings suggest strong antifungal potential for Anadenanthera colubrina (Vell.) Brenan as well as a tendency toward diminishing the growth of human tumor cells.
Attachment, Growth, and Detachment of Human Mesenchymal Stem Cells in a Chemically Defined Medium

The manufacture of human mesenchymal stem cells (hMSCs) for clinical applications requires an appropriate growth surface and an optimized, preferably chemically defined medium (CDM) for expansion. We investigated a new protein/peptide-free CDM that supports the adhesion, growth, and detachment of an immortalized hMSC line (hMSC-TERT) as well as primary cells derived from bone marrow (bm-hMSCs) and adipose tissue (ad-hMSCs). We observed the rapid attachment and spreading of hMSC-TERT cells and ad-hMSCs in CDM concomitant with the expression of integrin and actin fibers. Cell spreading was promoted by coating the growth surface with collagen type IV and fibronectin. The growth of hMSC-TERT cells was similar in CDM and serum-containing medium whereas the lag phase of bm-hMSCs was prolonged in CDM. FGF-2 or surface coating with collagen type IV promoted the growth of bm-hMSCs, but laminin had no effect. All three cell types retained their trilineage differentiation capability in CDM and were detached by several enzymes (but not collagenase in the case of hMSC-TERT cells). The medium and coating did not affect detachment efficiency but influenced cell survival after detachment. CDM combined with cell-specific surface coatings and/or FGF-2 supplements is therefore as effective as serum-containing medium for the manufacture of different hMSC types.
Expert credibility in climate change

Although preliminary estimates from published literature and expert surveys suggest striking agreement among climate scientists on the tenets of anthropogenic climate change (ACC), the American public expresses substantial doubt about both the anthropogenic cause and the level of scientific agreement underpinning ACC. A broad analysis of the climate scientist community itself, the distribution of credibility of dissenting researchers relative to agreeing researchers, and the level of agreement among top climate experts has not been conducted and would inform future ACC discussions. Here, we use an extensive dataset of 1,372 climate researchers and their publication and citation data to show that (i) 97–98% of the climate researchers most actively publishing in the field surveyed here support the tenets of ACC outlined by the Intergovernmental Panel on Climate Change, and (ii) the relative climate expertise and scientific prominence of the researchers unconvinced of ACC are substantially below that of the convinced researchers.
UVB phototherapy and photochemotherapy (PUVA) in the treatment of polymorphic light eruption and solar urticaria

Forty subjects (36 with polymorphic light eruption and four with solar urticaria) were treated during the spring and early summer of the years 1982 to 1985 with either UVB phototherapy (a total of 54 treatment courses in subjects with polymorphic light eruption) or photochemotherapy (PUVA) (18 treatment courses in polymorphic light eruption and eight in solar urticaria patients). Both forms of prophylactic therapy were found to be effective in 90%, of those with polymorphic light eruption, and PUVA in all those with solar urticaria. The optimum duration of treatment was 5 weeks. Adverse reactions, although common, were usually slight and rarely required alteration of the treatment regimen.
Hierarchical Affinity Propagation

Affinity propagation is an exemplar-based clustering algorithm that finds a set of data-points that best exemplify the data, and associates each datapoint with one exemplar. We extend affinity propagation in a principled way to solve the hierarchical clustering problem, which arises in a variety of domains including biology, sensor networks and decision making in operational research. We derive an inference algorithm that operates by propagating information up and down the hierarchy, and is efficient despite the high-order potentials required for the graphical model formulation. We demonstrate that our method outperforms greedy techniques that cluster one layer at a time. We show that on an artificial dataset designed to mimic the HIV-strain mutation dynamics, our method outperforms related methods. For real HIV sequences, where the ground truth is not available, we show our method achieves better results, in terms of the underlying objective function, and show the results correspond meaningfully to geographical location and strain subtypes. Finally we report results on using the method for the analysis of mass spectra, showing it performs favorably compared to state-of-the-art methods.
Revisiting the hemispheric asymmetry in midlatitude ozone changes following the Mount Pinatubo eruption: A 3‐D model study

Following the eruption of Mount Pinatubo, satellite and in situ measurements showed a large enhancement in stratospheric aerosol in both hemispheres, but significant midlatitude column O3 depletion was observed only in the north. We use a three‐dimensional chemical transport model to determine the mechanisms behind this hemispheric asymmetry. The model, forced by European Centre for Medium‐Range Weather Forecasts ERA‐Interim reanalyses and updated aerosol surface area density, successfully simulates observed large column NO2 decreases and the different extents of ozone depletion in the two hemispheres. The chemical ozone loss is similar in the Northern (NH) and Southern Hemispheres (SH), but the contrasting role of dynamics increases the depletion in the NH and decreases it in the SH. The relevant SH dynamics are not captured as well by earlier ERA‐40 reanalyses. Overall, the smaller SH column O3 depletion can be attributed to dynamical variability and smaller SH background lower stratosphere O3 concentrations.