Miracle-dz/UniFAR-FTUs huggingface dataset:
A New Miniature Wind Turbine for Wind Tunnel Experiments. Part I: Design and Performance

Miniature wind turbines, employed in wind tunnel experiments to study the interaction of turbines with turbulent boundary layers, usually suffer from poor performance with respect to their large-scale counterparts in the field. Moreover, although wakes of wind turbines have been extensively examined in wind tunnel studies, the proper characterization of the performance of wind turbines has received relatively less attention. In this regard, the present study concerns the design and the performance analysis of a new three-bladed horizontal-axis miniature wind turbine with a rotor diameter of 15 cm. Due to its small size, this turbine, called WiRE-01, is particularly suitable for studies of wind farm flows and the interaction of the turbine with an incoming boundary-layer flow. Especial emphasis was placed on the accurate measurement of the mechanical power extracted by the miniature turbine from the incoming wind. In order to do so, a new setup was developed to directly measure the torque of the rotor shaft. Moreover, to provide a better understanding on the connection between the mechanical and electrical aspects of miniature wind turbines, the performance of three different direct-current (DC) generators was studied. It is found that electrical outputs of the tested generators can be used to provide a rather acceptable estimation of the mechanical input power. Force and power measurements showed that the thrust and power coefficients of the miniature turbine can reach 0.8 and 0.4 , respectively, which are close to the ones of large-scale turbines in the field. In Part II of this study, the wake structure and dynamic flow characteristics are studied for the new miniature turbine immersed in a turbulent boundary-layer flow.
Cross-cultural adaptation, reliability, and validation of the Korean version of the identification functional ankle instability (IdFAI)

Abstract Purpose: To cross-culturally adapt the Identification Functional Ankle Instability for use with Korean-speaking participants. Methods: The English version of the IdFAI was cross-culturally adapted into Korean based on the guidelines. The psychometric properties in the Korean version of the IdFAI were measured for test-retest reliability, internal consistency, criterion-related validity, discriminative validity, and measurement error 181 native Korean-speakers. Results: Intra-class correlation coefficients (ICC2,1) between the English and Korean versions of the IdFAI for test–retest reliability was 0.98 (standard error of measurement = 1.41). The Cronbach’s alpha coefficient was 0.89 for the Korean versions of IdFAI. The Korean versions of the IdFAI had a strong correlation with the SF-36 (rs = −0.69, p < .001) and the Korean version of the Cumberland Ankle Instability Tool (rs = −0.65, p < .001). The cutoff score of >10 was the optimal cutoff score to distinguish between the group memberships. The minimally detectable change of the Korean versions of the IdFAI score was 3.91. Conclusion: The Korean versions of the IdFAI have shown to be an excellent, reliable, and valid instrument. The Korean versions of the IdFAI can be utilized to assess the presence of Chronic Ankle Instability by researchers and clinicians working among Korean-speaking populations. Implications for rehabilitation The high recurrence rate of sprains may result into Chronic Ankle Instability (CAI). The Identification of Functional Ankle Instability Tool (IdFAI) has been validated and recommended to identify patients with Chronic Ankle Instability (CAI). The Korean version of the Identification of Functional Ankle Instability Tool (IdFAI) may be also recommend to researchers and clinicians for assessing the presence of Chronic Ankle Instability (CAI) in Korean-speaking population.
DIRECT AND INDIRECT ACCESS TO CORPORA : AN EXPLORATORY CASE STUDY COMPARING STUDENTS ’ ERROR CORRECTION AND LEARNING STRATEGY USE IN L 2 WRITING

Hyunsook Yoon, Hankuk University of Foreign Studies Jung Won Jo, Hankuk University of Foreign Studies Studies on students’ use of corpora in L2 writing have demonstrated the benefits of corpora not only as a linguistic resource to improve their writing abilities but also as a cognitive tool to develop their learning skills and strategies. Most of the corpus studies, however, adopted either direct use or indirect use of corpora by students, without comparing the effectiveness between the two applications. This case study seeks to develop new lines of inquiry by comparing the effectiveness and learning strategy use in corpus-based writing revision. Four Korean EFL students used introspective and retrospective research instruments in an investigation of the effects of corpus use on error correction, error correction patterns, and learning strategy use between the two approaches. While we caution about drawing a conclusion from this small case study, the needs-based approach to corpus use in L2 writing was found to be effective for restructuring the learners’ errant knowledge about language use. The approach drove students to actively adopt cognitive learning strategies by performing as “language detectives. ” Different effectiveness and learning strategy uses were also observed relative to the corpus use contexts as well as according to student proficiency levels. We also found pedagogical implications, which will be discussed, in relation to the two different corpus applications.
"We got mail": electronic communication between physicians and patients.

E-mail has the potential to improve both the quality and efficiency of healthcare service delivery. Despite the substantial growth of this form of communication over the past decade, its promise to patients, providers, and their health plans remains largely untapped. In this article we (1) review the literature on e-mail use between patients and providers; (2) identify challenges and opportunities facing managed care organizations that wish to maximize the potential of this form of communication; (3) describe the components of 2 systems aimed at enhancing e-mail use in clinical settings; and (4) discuss the implications of increased e-mail use for managed care.
Identification of Prodromal Signs and Symptoms and Early Intervention in Manic Depressive Psychosis Patients: A Case Example

Recent research has revealed that relapse in manic depressive psychosis and schizophrenia is preceded by specific prodromal signs and symptoms that include dysphoria, other non-psychotic symptoms and features unique to individual patients. Treatment studies in schizophrenia have shown that early pharmacological intervention during a prodromal phase of psychotic relapse may be effective in the prevention of hospitalization. This paper describes the procedure of prodromal signs identification in manic depressive psychosis and the negotiation of an appropriate plan of action with the mental health services in order to abort the relapse or reduce its severity through early pharmacological intervention. A case example is presented to demonstrate this approach.
An update on the pharmacological management of endometriosis

Introduction: Endometriosis is a common disease that causes pain symptoms and/or infertility in women in their reproductive years. The disease is characterised by the presence of endometrium-like tissue – glands and stroma – outside the uterine cavity. Different treatment options exist for endometriosis including medical and surgical treatments or a combination of the two approaches. The most commonly used medications are non-steroidal anti-inflammatory drugs, GnRH agonists, androgen derivatives such as danazol, combined oral contraceptive pills, progestogens and more recently the levonorgestrel intrauterine system. Areas covered: The authors review current medical treatments used for symptomatic endometriosis and also discuss new treatment approaches. The authors conducted a literature search for randomised controlled trials related to medical treatments of endometriosis in humans, searched the Cochrane library for reviews and also searched for registered trials that have not yet been published on ClinicalTrials.gov. Expert opinion: The medical treatment of endometriosis is effective at treating pain and preventing recurrence of disease after surgery. Remarkably, the oral contraceptive pill taken continuously is as effective as GnRH-a, while causing far less side-effects. Conversely, no treatment currently exists for enhancing fecundity in women whose infertility is associated with endometriosis. As all existing therapies of endometriosis are contraceptive, great efforts should be targeted at researching novel products that reduce the disease expression without shuttering ovulation.
KPFM/AFM imaging on TiO2(110) surface in O2 gas

We have carried out high-speed imaging of the topography and local contact potential difference (LCPD) on rutile TiO2(110) in O2 gas by atomic force microscopy (AFM) and Kelvin probe force microscopy (KPFM). We succeeded in KPFM/AFM imaging with atomic resolution at 1 frame min−1 and observed the adsorbate on a hydroxylated TiO2(110) surface. The observed adsorbate is considered to be oxygen adatoms (Oa), hydroperoxyls (HO2), or terminal hydroxyls (OHt). After adsorption, changes in the topography and the LCPD of the adsorbate were observed. This phenomenon is thought to be caused by the charge transfer of the adsorbate. This technique has the potential to observe catalytic behavior with atomic resolution.
A multidimensional approach to measuring well-being in students: Application of the PERMA framework

Seligman recently introduced the PERMA model with five core elements of psychological well-being: positive emotions, engagement, relationships, meaning, and accomplishment. We empirically tested this multidimensional theory with 516 Australian male students (age 13–18). From an extensive well-being assessment, we selected a subset of items theoretically relevant to PERMA. Factor analyses recovered four of the five PERMA elements, and two ill-being factors (depression and anxiety). We then explored the nomological net surrounding each factor by examining cross-sectional associations with life satisfaction, hope, gratitude, school engagement, growth mindset, spirituality, physical vitality, physical activity, somatic symptoms, and stressful life events. Factors differentially related to these correlates, offering support for the multidimensional approach to measuring well-being. Directly assessing subjective well-being across multiple domains offers the potential for schools to more systematically understand and promote well-being.
The association of multiple sclerosis and Hodgkin's disease: the role of Epstein—Barr virus infection

The aetiology of multiple sclerosis (MS) is still an unresolved question. Several recently reported studies are implicating Epstein—Barr virus (EBV) as one of the key players in MS pathogenesis. We present a 21-year-old male patient with a history of EBV-related infectious mononucleosis in puberty and Hodgkin's disease two years previously treated with irradiation and chemotherapy. The patient presented with spastic paraparesis that resolved promptly on corticosteroid treatment. There were no signs of Hodgkin's disease relapse. In the next three years he had three more bouts of the disease and he was diagnosed with relapse—remitting MS. There is evidence of EBV involvement in MS pathogenesis; the association of MS with EBV-related infectious mononucleosis and Hodgkin's disease being just one of them. Although there are many unanswered questions, it is clear that without EBV seropositivity MS in adults is extremely rare. Multiple Sclerosis 2008; 14: 284—287. http://msj.sagepub. com
Medial septum regulates the hippocampal spatial representation

The hippocampal circuitry undergoes attentional modulation by the cholinergic medial septum. However, it is unclear how septal activation regulates the spatial properties of hippocampal neurons. We investigated here what is the functional effect of selective-cholinergic and non-selective septal stimulation on septo-hippocampal system. We show for the first time selective activation of cholinergic cells and their differential network effect in medial septum of freely-behaving transgenic rats. Our data show that depolarization of cholinergic septal neurons evokes frequency-dependent response from the non-cholinergic septal neurons and hippocampal interneurons. Our findings provide vital evidence that cholinergic effect on septo-hippocampal axis is behavior-dependent. During the active behavioral state the activation of septal cholinergic projections is insufficient to evoke significant change in the spiking of the hippocampal neurons. The efficiency of septo-hippocampal processing during active exploration relates to the firing patterns of the non-cholinergic theta-bursting cells. Non-selective septal theta-burst stimulation resets the spiking of hippocampal theta cells, increases theta synchronization, entrains the spiking of hippocampal place cells, and tunes the spatial properties in a timing-dependent manner. The spatial properties are augmented only when the stimulation is applied in the periphery of the place field or 400–650 ms before the animals approached the center of the field. In summary, our data show that selective cholinergic activation triggers a robust network effect in the septo-hippocampal system during inactive behavioral state, whereas the non-cholinergic septal activation regulates hippocampal functional properties during explorative behavior. Together, our findings uncover fast septal modulation on hippocampal network and reveal how septal inputs up-regulate and down-regulate the encoding of spatial representation.
Integrative models of nutrient balancing: application to insects and vertebrates

Abstract We present and apply to data for insects, chickens and rats a conceptual and experimental framework for studying nutrition as a multi-dimensional phenomenon. The framework enables the unification within a single geometrical model of several nutritionally relevant measures, including: the optimal balance and amounts of nutrients required by an animal in a given time (the intake target), the animal's current state in relation to these requirements, available foods, the amounts of ingested nutrients which are retained and eliminated, and animal performance. Animals given a nutritionally balanced food, or two or more imbalanced but complementary foods, can satisfy their nutrient requirements, and hence optimize performance. However, animals eating noncomplementary imbalanced foods must decide on a suitable compromise between overingesting some nutrients and underingesting others. The geometrical models provide a means of measuring nutritional targets and rules of compromise, and comparing these among different animals and within similar animals at different developmental stages or in different environments. They also provide a framework for designing and interpreting experiments on the regulatory and metabolic mechanisms underlying nutritional homeostasis.
Larynx Organ Preservation in Patients with Hypopharyngeal-Laryngeal Cancer

Object: The therapeutic options for advanced laryngeal-hypopharyngeal cancer have broadened in the last decades, in the attempt to cure the cancer sparing laryngeal functions and to improve quality of life (functional surgery, chemo- radiotherapy, combined therapy). Methods: We propose a single-centre based retrospective study on the results of the treatment of larynx-hypopharynx cancer on the basis of the different therapies offered, focusing on advanced-stage cancers. Among 146 patients with laryngeal-hypopharyngeal cancer treated in the period 1999-2006, we focused on 64 patients with advanced stage resectable cancer. In the larynx cancer group ? n = 40-, 32 patients had surgery and 8 patients had CT-RT (refusal of laryngectomy or relative contraindications to surgery). In the hypopharynx cancer group ? n = 24-, 16 patients underwent surgery and 8 patients had CT-RT. The outcome measure considered has been overall survival. Results: Larynx cancer group. Overall survival: after surgery we observed a 3-year survival of 62%, and a 5-year survival of 44%, while after CT-RT we had a 3-year survival of 25% and a 5-year survival of 12%. Hypopharynx cancer group. Overall survival: surgery: 3-year survival: 40%, 5-year survival 32%; CT-RT: 3-year survival: 50%, 5-year survival: 34%. Conclusion: The results emphasize the use of larynx-preserving approaches for appropriately selected patients without a compromise in survival; in our case series, surgery had better outcome than CT-RT in advanced-stage larynx cancer; whilst no significant differences were observed in the treatment of hypopharynx cancer.
Development and Preclinical Application of an Immunocompetent Transplant Model of Basal Breast Cancer with Lung, Liver and Brain Metastases

Triple negative breast cancer (TNBC) is an aggressive subtype of breast cancer that is associated with a poor prognosis and for which no targeted therapies currently exist. In order to improve preclinical testing for TNBC that relies primarily on using human xenografts in immunodeficient mice, we have developed a novel immunocompetent syngeneic murine tumor transplant model for basal-like triple-negative breast cancer. The C3(1)/SV40-T/t-antigen (C3(1)/Tag) mouse mammary tumor model in the FVB/N background shares important similarities with human basal-like TNBC. However, these tumors or derived cell lines are rejected when transplanted into wt FVB/N mice, likely due to the expression of SV40 T-antigen. We have developed a sub-line of mice (designated REAR mice) that carry only one copy of the C3(1)/Tag-antigen transgene resulting from a spontaneous transgene rearrangement in the original founder line. Unlike the original C3(1)/Tag mice, REAR mice do not develop mammary tumors or other phenotypes observed in the original C3(1)/Tag transgenic mice. REAR mice are more immunologically tolerant to SV40 T-antigen driven tumors and cell lines in an FVB/N background (including prostate tumors from TRAMP mice), but are otherwise immunologically intact. This transplant model system offers the ability to synchronously implant the C3(1)/Tag tumor-derived M6 cell line or individual C3(1)/Tag tumors from various stages of tumor development into the mammary fat pads or tail veins of REAR mice. C3(1)/Tag tumors or M6 cells implanted into the mammary fat pads spontaneously metastasize at a high frequency to the lung and liver. M6 cells injected by tail vein can form brain metastases. We demonstrate that irradiated M6 tumor cells or the same cells expressing GM-CSF can act as a vaccine to retard tumor growth of implanted tumor cells in the REAR model. Preclinical studies performed in animals with an intact immune system should more authentically replicate treatment responses in human patients.
Increased Survival of Antibiotic-Resistant Escherichia coli inside Macrophages

ABSTRACT Mutations causing antibiotic resistance usually incur a fitness cost in the absence of antibiotics. The magnitude of such costs is known to vary with the environment. Little is known about the fitness effects of antibiotic resistance mutations when bacteria confront the host's immune system. Here, we study the fitness effects of mutations in the rpoB, rpsL, and gyrA genes, which confer resistance to rifampin, streptomycin, and nalidixic acid, respectively. These antibiotics are frequently used in the treatment of bacterial infections. We measured two important fitness traits—growth rate and survival ability—of 12 Escherichia coli K-12 strains, each carrying a single resistance mutation, in the presence of macrophages. Strikingly, we found that 67% of the mutants survived better than the susceptible bacteria in the intracellular niche of the phagocytic cells. In particular, all E. coli streptomycin-resistant mutants exhibited an intracellular advantage. On the other hand, 42% of the mutants incurred a high fitness cost when the bacteria were allowed to divide outside of macrophages. This study shows that single nonsynonymous changes affecting fundamental processes in the cell can contribute to prolonged survival of E. coli in the context of an infection.
Measuring the Impact of Electronic Publishing on Citation Indicators of Education Journals

With the growth in electronic availability and distribution of scholarly journals, citation indicators of these journals may be expected to change. This study estimated how electronic publishing affects citation indicators, Impact Factors and Immediacy Indexes, from 1995 to 2003. Two citation indicators of 70 journals in education, educational research, and special education in Journal Citations Reports were analysed in this study. The result shows that Impact Factors remain essentially unchanged while Immediacy Indexes increased significantly. For all journals, 75% had their Immediacy Indexes increase drastically recently and had higher Impact Factors than average. Because more journal articles are available in electronic form, both as part of complete electronic journals and within databases of separate articles, many more scientists access and use new articles without delay than in the past. Electronic publishing can be regarded as one of the factors affecting not only citation frequencies but also citation indicators. Digital access to scholarly journals promises to bring changes in citation indicators, especially Immediacy Indexes of well-established journals in education.
Dwarf Spheroidal Satellite Galaxies without Dark Matter: Results from Two Different Numerical Techniques

Self-consistent simulations of the dynamical evolution of a low-mass satellite galaxy without dark matter are reported. The orbits have eccentricities of 0.41 ≤ e ≤ 0.96 in a Galactic dark halo with a mass of 2.85 × 1012 M☉ and 4.5 × 1011 M☉. A particle-mesh code with nested subgrids and a direct-summation N-body code running with the special-purpose hardware device GRAPE are used for the simulations. Initially, the satellite is spherical with an isotropic velocity distribution and a mass of 107 M☉. Simulations with 1.3 × 105 up to 2 × 106 satellite particles are performed. The calculations proceed for many orbital periods, until well after the satellite disrupts. In all cases, the dynamical evolution converges to a remnant that contains roughly 1% of the initial satellite mass. The stable remnant results from severe tidal shaping of the initial satellite. To an observer from Earth, these remnants appear strikingly similar to the Galactic dwarf spheroidal satellite galaxies. Their apparent mass-to-light ratios are very large, despite the fact that they contain no dark matter. These computations show that a remnant without dark matter displays larger line-of-sight velocity dispersions, σ, for more eccentric orbits, as a result of projection onto the observational plane. Assuming that they are not dark matter dominated, it follows that the Galactic dSph satellites with σ > 6 km s-1 should have orbital eccentricities of e > 0.5. Some remnants have substructure along the line of sight that may be apparent in the morphology of the horizontal branch.