Miracle-dz/UniFAR-FTUs huggingface dataset:
Extended double disc synergy testing reveals a low prevalence of extended-spectrum beta-lactamases in Enterobacter spp. in Vienna, Austria.

OBJECTIVES The aims of this study were to determine the prevalence of extended-spectrum beta-lactamases (ESBLs) in AmpC-carrying Enterobacter spp. in a tertiary care university hospital in Vienna, Austria, and to implement a cost-effective strategy to detect ESBLs in this particular genus on a routine basis. METHODS Clinical Enterobacter isolates (n=208) were investigated by means of (i) an inhibitor-potentiated diffusion test using cefpodoxime, (ii) an expanded double disc diffusion synergy test (discs of cefotaxime, ceftazidime, cefpodoxime and cefepime placed around amoxicillin/clavulanic acid), (iii) the Etest ESBL screening method and (iv) the cefoxitin-cefotaxime antagonist test. Cefepime MICs were determined by separate Etests. RESULTS Of 208 isolates, 76 (37%), 18 (9%) and 92 (44%) were derepressed, partially derepressed and inducible AmpC producers, respectively. Eight (4%) ESBL-producing Enterobacter strains could be detected, all of which would have been detected using disc-based tests. Six out of eight strains were genetically not related, as assessed by random amplification of polymorphic DNA. Typing results were confirmed by means of enterobacterial repetitive intergenic consensus PCR. The MIC(90) of cefepime was not different in ESBL carriers (range 2-4 mg/L), and was especially low in inducible AmpC producers (0.125 mg/L). More than half of all Enterobacter isolates (n=110; 53%) were partly derepressed or fully inducible AmpC producers. In the absence of cefoxitin, they appeared susceptible or intermediately susceptible to cefazolin (n=8; 9%), cefuroxime (n=75; 81.5%), ceftazidime (n=91; 99%), cefotaxime (n=92; 100%), cefpodoxime (n=75; 81.5%) and cefepime (n=91; 99%). CONCLUSIONS Susceptibility to third-generation cephalosporins would have been falsely assumed in more than half of all Enterobacter isolates, but ESBL in Enterobacter is currently rare in our institution. Integration of multiple double disc tests into the routine antibiogram seems a reliable approach to screen for emerging resistance mechanisms. Etests did not provide additional information in this study.
Multisensor multitarget bias estimation for general asynchronous sensors

A novel solution is provided for the bias estimation problem in multiple asynchronous sensors using common targets of opportunity. The decoupling between the target state estimation and the sensor bias estimation is achieved without ignoring or approximating the crosscovariance between the state estimate and the bias estimate. The target data reported by the sensors are usually not time-coincident or synchronous due to the different data rates. Since the bias estimation requires time-coincident target data from different sensors, a novel scheme is used to transform the measurements from the different times of the sensors into pseudomeasurements of the sensor biases with additive noises that are zero-mean, white, and with easily calculated covariances. These results allow bias estimation as well as the evaluation of the Cramer-Rao lower bound (CRLB) on the covariance of the bias estimate, i.e., the quantification of the available information about the biases in any scenario. Monte Carlo simulation results show that the new method is statistically efficient, i.e., it meets the CRLB. The use of this technique for scale and sensor location biases in addition to the usual additive biases is also presented.
Weak response of oceanic dimethylsulfide to upper mixing shoaling induced by global warming

The solar radiation dose in the oceanic upper mixed layer (SRD) has recently been identified as the main climatic force driving global dimethylsulfide (DMS) dynamics and seasonality. Because DMS is suggested to exert a cooling effect on the earth radiative budget through its involvement in the formation and optical properties of tropospheric clouds over the ocean, a positive relationship between DMS and the SRD supports the occurrence of a negative feedback between the oceanic biosphere and climate, as postulated 20 years ago. Such a natural feedback might partly counteract anthropogenic global warming through a shoaling of the mixed layer depth (MLD) and a consequent increase of the SRD and DMS concentrations and emission. By applying two globally derived DMS diagnostic models to global fields of MLD and chlorophyll simulated with an Ocean General Circulation Model coupled to a biogeochemistry model for a 50% increase of atmospheric CO2 and an unperturbed control run, we have estimated the response of the DMS-producing pelagic ocean to global warming. Our results show a net global increase in surface DMS concentrations, especially in summer. This increase, however, is so weak (globally 1.2%) that it can hardly be relevant as compared with the radiative forcing of the increase of greenhouse gases. This contrasts with the seasonal variability of DMS (1000–2000% summer-to-winter ratio). We suggest that the “plankton–DMS–clouds–earth albedo feedback” hypothesis is less strong a long-term thermostatic system than a seasonal mechanism that contributes to regulate the solar radiation doses reaching the earth's biosphere.
The effects of acute temperature change on swimming performance in bluegill sunfish Lepomis macrochirus

SUMMARY Many fish change gait within their aerobically supported range of swimming speeds. The effects of acute temperature change on this type of locomotor behavior are poorly understood. Bluegill sunfish swim in the labriform mode at low speeds and switch to undulatory swimming as their swimming speed increases. Maximum aerobic swimming speed (Umax), labriform-undulatory gait transition speed (Utrans) and the relationships between fin beat frequency and speed were measured at 14, 18, 22, 26 and 30°C in bluegill acclimated to 22°C. At temperatures below the acclimation temperature (Ta), Umax, Utrans and the caudal and pectoral fin beat frequencies at these speeds were reduced relative to the acclimation level. At temperatures above Ta there was no change in these variables relative to the acclimation level. Supplementation of oxygen levels at 30°C had no effect on swimming performance. The mechanical power output of the abductor superficialis, a pectoral fin abductor muscle, was measured in vitro at the same temperatures used for the swimming experiments. At and below Ta, maximal power output was produced at a cycle frequency approximately matching the in vivo pectoral fin beat frequency. At temperatures above Ta muscle power output and cycle frequency could be increased above the in vivo levels at Utrans. Our data suggest that the factors triggering the labriform–undulatory gait transition change with temperature. Muscle mechanical performance limited labriform swimming speed at Ta and below, but other mechanical or energetic factors limited labriform swimming speed at temperatures above Ta.
Prevalence of Optic Disc Hemorrhages in Rural Central India. The Central India Eye and Medical Study

Purpose To determine the frequency of optic disc hemorrhages in a rural Indian population. Methods The population-based Central Indian Eye and Medical Study included 4711 subjects. Mean age was 48.5±12.9 years (range: 30-100 years). Color optic disc photographs were examined. Results Optic disc photographs were available for 4570 (97.0%) subjects. Prevalence of disc hemorrhages was 17/8869 (0.19%; 95%CI:0.10,0.28) per eye and 16/4570 (0.35±0.09%; 95%CI:0.18,0.52) per subject. Prevalence of disc hemorrhages increased from 0.05% (95%CI:0.00,0.13) in the age group of 30-39 years to 0.25% (95CI:0.00,0.49) in the age group of 60-69 years and to 0.91% (95%CI:0.24,1.58) in the age group of 70+ years. After adjusting for older age, higher systolic blood pressure, diabetes mellitus, myopic refractive error, smaller neuroretinal rim area and thinner retinal nerve fiber layer, occurrence of disc hemorrhages was associated only with glaucomatous optic nerve damage (P<0.001; Odds ratio: 87; 95%CI:32,239). Eleven of the 17 (65%; 95%CI:39,90) disc hemorrhages were found in glaucomatous eyes. Out of 193 glaucomatous eyes, 11 eyes (5.7%; 95%CI:2.4,9.0) showed a disc hemorrhage. Out of the 8676 non-glaucomatous eyes, 6 eyes (0.07%; 95%CI:0.01,0.12) had an optic disc hemorrhage. Conclusions Prevalence of disc hemorrhages (0.2% per eye; 0.4% per subject) in Indians aged 30+ years was strongly associated with glaucoma after adjustment for age, blood pressure and diabetes mellitus. A disc hemorrhage suggested glaucomatous optic nerve damage with a positive predictive value of 65%. About 6% of glaucomatous eyes showed a disc hemorrhage at the time of clinical examination highlighting the importance of optic disc hemorrhages for the diagnosis of glaucoma.
Three Essays In Macroeconomics and Monetary Economics Using Bayesian Multivariate Smooth Transition Approaches

A feedback-based adaptive network is described wherein at least a portion of the network elements report operating information relating to network conditions to a centralized data store. The information which is reported to the data store is analyzed by a policy engine which includes a plurality of application specific plug-in policies for analyzing selected information from the data store and for computing updated control information based upon the analysis of the information. The updated control information is fed back to selected network elements to thereby affect operation of the selected elements. Additionally the adaptive, feedback-based network of the present invention may include a network quality monitoring system for evaluating performance characteristics or other aspects of the network based upon predetermined standards or criteria.
Going Public without Governance: Managerial Reputation Effects

This paper addresses the agency problem between controlling shareholders and minority shareholders. This problem is common among public firms in many countries where the legal system does not effectively protect minority shareholders against oppression by controlling shareholders. We show that even without any explicit corporate governance mechanisms protecting minority shareholders, controlling shareholders can implicitly commit not to expropriate them. Stock prices of such companies are significantly higher and firms are more likely go public because of this reputation effect. Moreover, insiders divest shares gradually over time, at a rate that is negatively related to the degree of moral hazard. Copyright The American Finance Association 2000.
Cell reprogramming modelled as transitions in a hierarchy of cell cycles

We construct a model of cell reprogramming (the conversion of fully differentiated cells to a state of pluripotency, known as induced pluripotent stem cells, or iPSCs) which builds on key elements of cell biology viz. cell cycles and cell lineages. Although reprogramming has been demonstrated experimentally, much of the underlying processes governing cell fate decisions remain unknown. This work aims to bridge this gap by modelling cell types as a set of hierarchically related dynamical attractors representing cell cycles. Stages of the cell cycle are characterised by the configuration of gene expression levels, and reprogramming corresponds to triggering transitions between such configurations. Two mechanisms were found for reprogramming in a two level hierarchy: cycle specific perturbations and a noise induced switching. The former corresponds to a directed perturbation that induces a transition into a cycle-state of a different cell type in the potency hierarchy (mainly a stem cell) whilst the latter is a priori undirected and could be induced, e.g. by a (stochastic) change in the cellular environment. These reprogramming protocols were found to be effective in large regimes of the parameter space and make specific predictions concerning reprogramming dynamics which are broadly in line with experimental findings.
Research Commentary - Too Big to Fail: Large Samples and the p-Value Problem

The Internet has provided IS researchers with the opportunity to conduct studies with extremely large samples, frequently well over 10,000 observations. There are many advantages to large samples, but researchers using statistical inference must be aware of the p-value problem associated with them. In very large samples, p-values go quickly to zero, and solely relying on p-values can lead the researcher to claim support for results of no practical significance. In a survey of large sample IS research, we found that a significant number of papers rely on a low p-value and the sign of a regression coefficient alone to support their hypotheses. This research commentary recommends a series of actions the researcher can take to mitigate the p-value problem in large samples and illustrates them with an example of over 300,000 camera sales on eBay. We believe that addressing the p-value problem will increase the credibility of large sample IS research as well as provide more insights for readers.
Degree centrality and eigenvector centrality in twitter

Network formed between users in a social media can be used to encourage information spreading among them. This research applied Social Network Analysis which further can be used to social media marketing to improve the marketing process effectively. Based on previous research, information spreading speed among the social media is affected by the users' activity connection which can be represented in centrality value. The centrality value itself is very affected by the graph structure and weights. This research applied degree and eigenvector centrality to observe the effect of centrality value for twitter data. The result shows that there is significant difference among 10 most influential users. This result will be used for the future research that will be focused in small and medium enterprise (SME) twitter data.
A MAP-based Online Estimation Approach to Ensemble Speaker and Speaking Environment Modeling

An ensemble speaker and speaking environment modeling (ESSEM) approach was recently developed. This ESSEM process consists of offline and online phases. The offline phase establishes an environment structure using speech data collected under a wide range of acoustic conditions, whereas the online phase estimates a set of acoustic models that matches the testing environment based on the established environment structure. Since the estimated acoustic models accurately characterize particular testing conditions, ESSEM can improve the speech recognition performance under adverse conditions. In this work, we propose two maximum a posteriori (MAP) based algorithms to improve the online estimation part of the original ESSEM framework. We first develop MAP-based environment structure adaptation to refine the original environment structure. Next, we propose to utilize the MAP criterion to estimate the mapping function of ESSEM and enhance the environment modeling capability. For the MAP estimation, three types of priors are derived; they are the clustered prior (CP), the sequential prior (SP), and the hierarchical prior (HP) densities. Since each prior density is able to characterize specific acoustic knowledge, we further derive a combination mechanism to integrate the three priors. Based on the experimental results on the Aurora-2 task, we verify that using the MAP-based online mapping function estimation can enable ESSEM to achieve better performance than using the maximum-likelihood (ML) based counterpart. Moreover, by using an integration of the online environment structuring adaptation and mapping function estimation, the proposed MAP-based ESSEM framework is found to provide the best performance. Compared with our baseline results, MAP-based ESSEM achieves an average word error rate reduction of 15.53% (5.41 to 4.57%) under 50 testing conditions at a signal-to-noise ratio (SNR) of 0 to 20 dB over the three standardized testing sets.
BASEL II: OPERATIONAL RISK MEASUREMENT IN THE PORTUGUESE BANKING SECTOR

The present work focuses on one of the principal themes associated to the New Basel Accord – operational risk and its respective methodologies for calculating minimum capital requirements. The new capital accord encourages financial institutions to gradually evolve from basic to sophisticated methodologies. Institutions applying sophisticated methods will be rewarded with deductions on capital allocated when calculating the capital ratio. The methodologies related to operational risk will be applied to a group of national banking institutions. These methodologies are referred to in Pillar I of the new capital accord: (i) basic indicator approach, (ii) the standardized approach and (iii) the alternative standardized approach. The purpose of this practical application is to evaluate and quantify the impact on several national banks of the different approaches linked to operational risk, introduced by Basel II.
Responsiveness of the Spanish Version of the “Skin Cancer Index”

Background. Skin Cancer Index (SCI) is a specific questionnaire measuring health related quality of life (HRQL) in patients with cervicofacial non-melanoma skin cancer (CFNMSC). The original scale has recently been adapted and validated into Spanish. Objectives. Evaluate the responsiveness of the Spanish version of SCI. Methods. Patients with CFNMSC candidate for surgical treatment were administered the questionnaire at time of diagnostic (t 0), 7 days after surgery (t 1), and 5 months after surgery (t 2). The scale and subscales scores (C1: social/appearance, C2: emotional) were then evaluated. Differences between t 0-t 1, t 1-t 2, and t 0-t 2 were determined and a gender-and-age segmented analysis was performed. Results. 88 patients, 54.8% male, mean age 62.5 years, completed the study. Differences between t 0-t 1 and t 1-t 2 scores were statistically significant (p < 0.05). The lowest values were found at time of diagnosis and postsurgery. Women and patients under 65 years showed the lowest values at the three times. Limitations. Concrete geographic and cultural area. Clinical and histological variables are not analysed. Conclusions. Our results confirm responsiveness of the Spanish version of the SCI. Further development of the instrument in Spanish-speaking countries and populations will make it possible to extend worldwide research and knowledge horizons on skin cancer.
Biological aerosol particle concentrations and size distributions measured in pristine tropical rainforest air during AMAZE-08

GENERAL REMARKS The overall objective of this work is to ferret out the dynamics of biological aerosols from the total aerosols in the atmosphere of the Amazon rainforest by coupling data about particle size and shape, chemical tracers and abundance patterns. The work deploys two instruments in particular, the UVAPS and a semi-automated SEM. The novel contributions of this work are the demonstration of the utility of the instruments used here (and of their limits) and the observation of organic coatings of biological aerosols. This work also corroborates previous evidence that biological aerosols are a marked component of total aerosols and that their emissions show cyclic (diurnal) patterns. The research presented here is a technical tour de force in terms of sampling and analysis. However, the conclusions are not as strong
Assessment, Equity, and Diversity in Reforming America's Schools

National standards and assessments are being proposed as a strategy for improving schools in the United States. However, proposed federal policies for implementation raise serious concerns about the extent to which national standards and assessments alone will help improve the quality of public education for all or whether it will serve to deepen the already severe educational and economic cleavages that exist in this nation, especially along racial/ethnic lines. We examine the implications of this policy for equity and diversity in terms of antecedent instructional conditions, the proposed test, the testing context, and the diversity of learners to be assessed. Without a strong and serious commitment to opportunity to learn, this policy serves as a symbolic and political fiction rather than an instrumental one in improving schooling outcomes, particularly for disadvantaged urban and racial/ethnic minority students.
Guava Waste to Sustain Guava (Psidium guajava) Agroecosystem: Nutrient “Balance” Concepts

The Brazilian guava processing industry generates 5.5 M Mg guava waste year−1 that could be recycled sustainably in guava agro-ecosystems as slow-release fertilizer. Our objectives were to elaborate nutrient budgets and to diagnose soil, foliar, and fruit nutrient balances in guava orchards fertilized with guava waste. We hypothesized that (1) guava waste are balanced fertilizer sources that can sustain crop yield and soil nutrient stocks, and (2) guava agroecosystems remain productive within narrow ranges of nutrient balances. A 6-year experiment was conducted in 8-year old guava orchard applying 0–9–18–27–36 Mg ha−1 guava waste (dry mass basis) and the locally recommended mineral fertilization. Nutrient budgets were compiled as balance sheets. Foliar and fruit nutrient balances were computed as isometric log ratios to avoid data redundancy or resonance due to nutrient interactions and the closure to measurement unit. The N, P, and several other nutrients were applied in excess of crop removal while K was in deficit whatever the guava waste treatment. The foliar diagnostic accuracy reached 93% using isometric log ratios and knn classification, generating reliable foliar nutrient and concentration ranges at high yield level. The plant mined the soil K reserves without any significant effect on fruit yield and foliar nutrient balances involving K. High guava productivity can be reached at lower soil test K and P values than thought before. Parsimonious dosage of fresh guava waste should be supplemented with mineral K fertilizers to recycle guava waste sustainably in guava agroecosystems. Brazilian growers can benefit from this research by lowering soil test P and K threshold values to avoid over-fertilization and using fresh guava waste supplemented with mineral fertilizers, especially K. Because yield was negatively correlated with fruit acidity and Brix index, balanced plant nutrition and fertilization diagnosis will have to consider not only fruit yield targets but also fruit quality to meet requirements for guava processing.
Some Steps towards Realtime Control of a Spacecraft Simulator via a Brain-computer Interface

We explored the possibility of controlling a space-craft simulator in realtime using an analogue Brain-Computer Interface (BCI) for 2-D pointer control. This is an extremely difficult task, for which no previous attempt has been reported in the literature. Our system relies on an active display which produces event-related potentials in the user’s brain. By analysing these, it is able to produce control vectors for the user interface at a rate of 10 per second. In tests, users of the simulator were told to pass as close as possible to the Sun. The simulation’s initial velocity was randomly selected in such a way that, in the absence of suitable control, the space-craft would almost always miss the Sun. To obtain a successful outcome, users had to control the simulator continuously for approximately one minute in each run. Performance was very promising, on average users managing to satisfy the simulation success criterion in 67.5% of the runs. Furthermore, to study the potential of a collaborative approach to space-craft navigation, we developed collaborative versions of the BCI for pointer control where the system is controlled via the integration of the brain activity of two users. We analysed their performance using the data acquired when training the BCI for use in the simulator. The analysis indicates that a collaborative BCI can produce trajectories that are statistically significantly superior to those obtained in the single-user case. This suggests that the application of both single-user and collaborative BCIs to the domain of space navigation