Miracle-dz/UniFAR-FTUs huggingface dataset:
Activity Dependent Degeneration Explains Hub Vulnerability in Alzheimer's Disease

Brain connectivity studies have revealed that highly connected ‘hub’ regions are particularly vulnerable to Alzheimer pathology: they show marked amyloid-β deposition at an early stage. Recently, excessive local neuronal activity has been shown to increase amyloid deposition. In this study we use a computational model to test the hypothesis that hub regions possess the highest level of activity and that hub vulnerability in Alzheimer's disease is due to this feature. Cortical brain regions were modeled as neural masses, each describing the average activity (spike density and spectral power) of a large number of interconnected excitatory and inhibitory neurons. The large-scale network consisted of 78 neural masses, connected according to a human DTI-based cortical topology. Spike density and spectral power were positively correlated with structural and functional node degrees, confirming the high activity of hub regions, also offering a possible explanation for high resting state Default Mode Network activity. ‘Activity dependent degeneration’ (ADD) was simulated by lowering synaptic strength as a function of the spike density of the main excitatory neurons, and compared to random degeneration. Resulting structural and functional network changes were assessed with graph theoretical analysis. Effects of ADD included oscillatory slowing, loss of spectral power and long-range synchronization, hub vulnerability, and disrupted functional network topology. Observed transient increases in spike density and functional connectivity match reports in Mild Cognitive Impairment (MCI) patients, and may not be compensatory but pathological. In conclusion, the assumption of excessive neuronal activity leading to degeneration provides a possible explanation for hub vulnerability in Alzheimer's disease, supported by the observed relation between connectivity and activity and the reproduction of several neurophysiologic hallmarks. The insight that neuronal activity might play a causal role in Alzheimer's disease can have implications for early detection and interventional strategies.
Spontaneous Iliopsoas Tendon Tear

Hip pain is one of the most common reasons for the elderly to present to the emergency department, and the differential diagnosis spectrum is vast. Iliopsoas injury is a relatively uncommon condition that may present with hip or groin pain. It is usually seen in athletes due to trauma, particularly flexion injuries. However, spontaneous iliopsoas tendon tear is extremely rare, and only a small number of cases have been reported; it has an estimated prevalence of 0.66% in individuals from 7 to 95 years. Risk factors include aging, use of steroids, and chronic diseases. Magnetic resonance imaging (MRI) using its high soft-tissue contrast resolution remains the most valuable imaging modality. A prompt diagnosis and treatment, which is usually conservative, is important to improve the quality of life in this group of patients. We describe a case of spontaneous iliopsoas tendon tear in an elderly woman.
Economic Globalization, the Macro Economy, and Reversals of Welfare: Expansion in Affluent Democracies, 1978–94

A key question in debates over globalization is its effect on the welfare states in particular on welfare “retrenchments”: programmatic retractions of the scope and coverage of social programs. We conceptualize such retrenchments as discrete policy events; and we offer a comprehensive model of their occurrence that integrates domestic economic, political, and institutional factors as well as those related to the global economy. Our analysis of all such retrenchments in Organization for Economic Cooperation and Development (OECD) nations between 1978 and 1994 indicates that the effects of globalization are complex, with trade openness and financial liberalization clearly operating against such retrenchments but outward foreign direct investment perhaps pressuring for them. In addition, we uncover support for a dynamic of “self-limiting immoderation”: economic and demographic pressures for costly welfare expenditures provoke actions to roll back eligibility and benefit rates that link increasing numbers of unemployed and retired persons to increased social spending. In short, the same demographic pressures that gave often been noted to substantially drive welfare spending may trigger welfare cutbacks.Our thanks to A. A. Alderson, Bob Jackman, Lane Kenworthy, Joakim Palme, Duane Swank, John Stephen, and two anonymous reviewers for their helpful comments and discussions, as well as to Kendralin Freedman for her work preparing the final manuscript. All remaining errors are our own. Previous versions of this article were presented at the Annual Meetings of the American Political Science Association and the American Sociological Association. The views expressed herein are those of the authors and do not reflect the opinions of the National Science Foundation or the U.S. government. All data and commands necessary to replicate the analyses presented here are available at our Web site 〈http://polisci.emory. edu/zorn/HZ/index.html〉.
Reproductive Biology and Endocrinology Open Access the Antiestrogen Ici 182,780 Induces Early Effects on the Adult Male Mouse Reproductive Tract and Long-term Decreased Fertility without Testicular Atrophy

Background: Estrogen receptors (ER) have important physiological roles in both the female and male reproductive systems. Previous studies using the estrogen receptor-α knockout mouse (αERKO) or antiestrogen treatment in adult rodents have shown that ERα is essential for normal function of the male reproductive tract. In the present study, time-response effects of the antiestrogen ICI 182,780 were determined to better understand ERα function in the adult male.
TEACHING, LEARNING AND ASSESSMENT: COMPLEMENTARY OR CONFLICTING CATEGORIES FOR SCHOOL STATISTICS

Over many years I have been attempting to improve statistical literacy in the population by changing the school curriculum. All such attempts have to be put in the general context of teaching, learning and assessing the subject. Ideally these should complement and reinforce each other. In practice they often conflict in particular assessment can distort the learning process. In this talk I consider the nature of these conflicts and how they might be overcome in practice, giving examples from a lifetime’s experience.
Imaging monetary reward in pathological gamblers

We acquired two 18F-deoxyglucose positron emisssion tomography (PET) scans on seven unmedicated pathological gamblers, at least 7 days apart. Following an injection of 5 mCi FDG, subjects carried out a computer blackjack task for 35 min under two different reward conditions: monetary reward and computer game points only. Relative FDG metabolic rate was obtained from regions of interest in the prefrontal cortex, cingulate, striatum and visual cortex. Monetary reward blackjack was associated with significantly higher relative metabolic rate in the primary visual cortex (Brodmann area 17), the cingulate gryus (Brodmann area 24), the putamen and prefrontal areas 47 and 10, compared to blackjack playing for points only. No area tested showed a significant decrease. This pattern suggests heightened limbic and sensory activation in the gambling for money condition with increased emotional valence and greater risk and reward, and confirms the salience of monetary reward in the development of pathological gambling.
Planning Fitness Training Sessions Using the Bat Algorithm

Over fairly recent years the concept of an ar- tificial sport trainer has been proposed in literature. This concept is based on computational intelligence algorithms. In this paper, we try to extend the artificial sports trainer by planning fitness training sessions that are suitable for athletes, especially during idle seasons when no competi- tion takes place (e.g., winter). The bat algorithm was used for planning fitness training sessions and results showed promise for the proposed solution. Future directions for development are also outlined in the paper.
Interest- and Content-Based Data Dissemination in Mobile Social Networks

With the increasing popularity of hand-held mobile devices such as smart phones and smart watches, people are connected more than ever, which enables the information to be created, forwarded, and exchanged at levels that one could not envision just a few years ago. Mobile social networks (MSNs) thrive with the popularity of mobile smart devices and exhibit the properties of social networks. To efficiently disseminate the information within MSNs, there have been research efforts on content-based routing schemes which rely on the network structure and user interest profiles. However, none of these prior works considered the impact of data content during data dissemination in MSNs. However such content is closely related to users' preferences, which have a significant influence on the result of the dissemination. To fill this void, we propose an interest- and content- based dissemination scheme in MSNs, where the contents of the messages, along with the network structural information are taken into consideration. In the proposed scheme, each user is associated with an interest profile and each message is associated with a message content profile. Similarities are measured between the users and the messages given their profiles. We also use PageRank to measure the importance of each user when the network evolves over time. Each piece of information is propagated based on the similarity scores and PageRank selection of relay users. We experimentally show that the proposed scheme achieves higher delivery performance compared to the existing schemes while remaining cost-effective.
Pregnancy Loss with Phospholipid Antibodies: Improved Outcome with Aspirin Containing Treatment

Summary: The obstetric outcome in 37 patients with antiphospholipid antibodies (APAs) is described. The APAs were measured by the lupus anticoagulant assay and/or more recently anticardiolipin antibodies. There were 15 patients with SLE who without therapy had 51/58 pregnancy failures, either abortion or fetal death in utero, a failure rate of 88%. Likewise, 22 patients without definite SLE lost 69/87 pregnancies, a failure rate of 79%. After treatment the pregnancy wastage rate was 55% and 25% in the 2 groups respectively. When treatment regimens used were examined in detail the improvement with therapy was most clearly evident in the group who received low dose aspirin (75–150mg) in association with immunosup‐pression. This improvement was most apparent in the patients without definite SLE.
Correlation among baseline variables yields non-uniformity of p-values

A recent paper in Neurology used statistical techniques to investigate the integrity of the randomization in 33 clinical trials conducted by a group of investigators. Without justification, the approach assumed that there would be no impact of correlation among baseline variables. We investigated the impact of correlation on the conclusions of the approach in several large-scale simulation studies that replicated the sample sizes and baseline variables of the clinical trials in question and utilized proper randomization. Additionally, we considered scenarios with larger numbers of baseline variables. We found that, with even moderate correlation, there can be substantial inflation of the type I error of statistical tests of randomization integrity. This is also the case under no correlation, in the presence of some discrete baseline variables, with a large number of variables. Thus, statistical techniques for assessing randomization integrity should be applied with extreme caution given that very low p-values, which are taken as evidence against valid randomization, can arise even in the case of valid randomization, in the presence of correlation. More generally, the use of tests of goodness of fit to uniformity for the purpose of testing a global null hypothesis is not advisable in the presence of correlation.
Defining the colour pattern phenotype in bumble bees (Bombus): A new model for evo devo

Few insects exhibit the striking colour pattern radiation found in bumble bees (Bombus), which have diversified globally into a wide range of colours and patterns. Their potent sting is often advertised by conspicuous bands of contrasting colour commonly mimicked by scores of harmless (Batesian mimics) and noxious species (Mullerian co-mimics). Despite extensive documentation of colour pattern diversification, next to nothing is known about the genetic regulation of pattern formation in bumble bees, hindering progress toward a more general model of the evolution of colour pattern mimicry. A critical first step in understanding the colour pattern genotype is an unambiguous understanding of the phenotype under selection, which has not been objectively defined in bumble bees. Here, we quantitatively define the principal colour pattern elements that comprise the phenotype array across all species. Matrix analysis of meticulously scored colour patterns of ∼95% of described species indicates there are 12 discrete primary ‘ground plan’ elements in common among all species, many of which correspond to segmentation patterning. Additional secondary elements characterize individual species and geographical variants. The boundaries of these elements appear to correspond to expression patterns of Hox genes in Drosophila and Apis but also suggest novel post-Hox specialization of abdominal patterning. Our findings provide the first foundation for exploring candidate genes regulating adaptive pattern variation in bumble bees and broaden the framework for understanding common genetic mechanisms of pattern evolution in insects. © 2014 The Linnean Society of London, Biological Journal of the Linnean Society, 2014, 113, 384‐404.
Properties of microtubule sliding disintegration in isolated tetrahymena cilia

Properties of the sliding disintegration response of demembranated tetrahymena cilia have been studied by measuring the spectrophotomeric response or turbidity of cilia suspensions at a wavelength of 350 nm relative to changes in the dynein substrate (MgATP(2-)) concentration. The maximum decrease in turbidity occurs in 20 muM ATP, and 90 percent of the decrease occurs in approximately 5.9 s. At lower ATP concentrations (1-20 muM), both the velocity and magnitude of the turbidity decreases are proportional to ATP concentration. The velocity data for 20 muM ATP permit construction of a reaction velocity curve suggesting that changes in turbidity are directly proportional to the extent and velocity of disintegration. At ATP concentrations more than 20 muM (50muM to 5mM), both velocity and magnitude of the turbidimetric response are reduced by approximately 50 percent. This apparent inhibition results in a biphasic response curve that may be related to activation of residual shear resistance or regulatory components at the higher ATP concentrations. The inhibitory effects of elevated ATP can be eliminated by mild trypsin proteolysis, whereupon the reaction goes to completion at any ATP concentration. The turbidimetric responses of the axoneme-substrate suspensions are consistent with the extent and type of axoneme disintegration revealed by electron microscope examination of the various suspensions, suggesting that the turbidimetric assay may prove to be a reliable means for assessing the state of axoneme integrity.
Escherichia coli Shiga Toxin Mechanisms of Action in Renal Disease

Shiga toxin-producing Escherichia coli is a contaminant of food and water that in humans causes a diarrheal prodrome followed by more severe disease of the kidneys and an array of symptoms of the central nervous system. The systemic disease is a complex referred to as diarrhea-associated hemolytic uremic syndrome (D+HUS). D+HUS is characterized by thrombocytopenia, microangiopathic hemolytic anemia, and acute renal failure. This review focuses on the renal aspects of D+HUS. Current knowledge of this renal disease is derived from a combination of human samples, animal models of D+HUS, and interaction of Shiga toxin with isolated renal cell types. Shiga toxin is a multi-subunit protein complex that binds to a glycosphingolipid receptor, Gb3, on select eukaryotic cell types. Location of Gb3 in the kidney is predictive of the sites of action of Shiga toxin. However, the toxin is cytotoxic to some, but not all cell types that express Gb3. It also can cause apoptosis or generate an inflammatory response in some cells. Together, this myriad of results is responsible for D+HUS disease.
A Distributed Clustered Architecture to Tackle Delay Variations in Datapath Synthesis

Due to the necessity of handling unexpected events in execution time, e.g., to support process variations, new mechanisms for dealing with every possible behavior of the datapath must be developed. Conventional centralized controllers can only handle very few dynamic events. Distributed controllers, on the other hand, are able to support every combination of events. These controllers are composed of several finite state machines, which are interconnected via a global coordinator. The use of this type of controller obliges to check the hazards between operations in run time, which entails some penalty in the controller complexity. In this paper, a new methodology for deploying a distributed controller over a set of clusters is presented. A register binding algorithm specially suited for distributed controllers has also been developed. It combines a clustering method and a least recently used policy to reduce the number of hazards in run time. Furthermore, our methodology allows the exploration of different solutions by tuning the input parameters of the binding algorithm. Several studies evaluating the execution time and area tradeoffs are presented to support our techniques. Results show that for some cases it is possible to reduce more than 50% the expected execution time, at the expense of a slight area increase.
“Owning” the personal past: Adolescents’ and adults’ autobiographical narratives and ratings of memories of recent and distant events

Adults and adolescents are characterised as having different perspectives on their personal or autobiographical memories. Adults are recognised as having vivid recollections of past events and as appreciating the meaning and significance of their autobiographical memories. In development, these qualities are noted as absent as late as adolescence. To evaluate the assumption of developmental differences, we directly compared autobiographical memories of adults and adolescents drawn from each of several periods in the past, using measures of narrative quality (coded independently) and participants’ own subjective ratings of their memories. Adults’ narratives of events from the previous year and for the “most significant” event of their lives were coded as more thematically coherent relative to those of adolescents’; the groups did not differ on thematic coherence of narratives of early-life events (ages 1–5 and 6–10 years). The ratings that adults and adolescents provided of their autobiographical memories were similar overall; differences were more apparent for early-life events than for more recent events and indicated stronger mnemonic experiences among adolescents than adults. The pattern of findings suggests that whereas adults have more sophisticated narrative tools for describing the significance of events and their relation to the corpus of autobiographical memories, adolescents as well as adults have vivid recollective experiences as well as personal and subjective perspective on the events of their lives and their memories thereof.
Effect of a preparation of Saccharomyces cerevisiae on microbial profiles and fermentation patterns in the large intestine of horses fed a high fiber or a high starch diet.

Eight horses were allotted into pairs consisting of one cecum- and right ventral colon-fistulated animal and one cecum-fistulated animal. They were fed daily at the same level of intake either a high-fiber (HF) or a high-starch (HS) diet without or with 10 g of a Saccharomyces cerevisiae preparation, in a 4 x 4 Latin square design. The HS diet provided a starch overload (i.e., 3.4 g starch x kg(-1) BW x meal(-1)) while maintaining a high amount of fiber intake (i.e., dietary NDF/starch ratio was 1.0). A 21-d period of adaptation to the treatments occurred before cecal and colonic contents were withdrawn 4 h after the morning meal to count total anaerobic, cellulolytic, and lactic acid-utilizing bacteria, lactobacilli, and streptococci. Lactic acid, volatile fatty acids, ammonia concentrations, and pH were measured on cecal and colonic fluid samples collected hourly during the first 12-h postfeeding. When the HS diet was fed, the concentration of total anaerobic and lactic acid-utilizing bacteria increased (P < 0.001), whereas that of cellulolytic bacteria decreased (P < 0.05) in the cecum. The concentration of lactobacilli and streptococci increased (P < 0.001) in the cecal and colonic contents. These alterations of the microbial profiles were associated with decreases (P < 0.001) of pH, (acetate + butyrate)/propionate ratio and with an increase (P < 0.001) of lactic acid concentration. Supplementing the S. cerevisiae preparation increased (P < 0.01) the concentration of viable yeast cells, averaging 4.3 x 10(6) and 4.5 x 10(4) cfu/mL in the cecal and colonic contents, respectively. Yeast supplementation had almost no effect on microbial counts in the cecum and colon. The supplementation of S. cerevisiae appeared to modify (P < 0.05) pH, concentrations of lactic acid and ammonia, molar percentages of acetate and butyrate with the HS diet and [(acetate + butyrate)/propionate] ratio when the HF diet was fed. The effects of the S. cerevisiae preparation were greater in the cecum than in the colon, which coincided with the abundance of yeast cells. When the digestion of starch in the small intestine was saturated, the effect of the addition of a S. cerevisiae preparation appeared to limit the extent of undesirable changes in the intestinal ecosystem of the horse.
Banks, Liquidity Management and Monetary Policy

We develop a new framework for studying the implementation of monetary policy through the banking sector. Banks are subject to a maturity mismatch problem leading to precautionary holdings of reserves. Through various instruments, monetary policy alters tradeos banks face between lending, holding reserves, holding deposits and paying dividends. This translates into the real economy via eects on real interests and lending. We study how these instruments interact with shocks to the volatility in the payments system, bank losses, the demand for loans and with capital requirements. We use a calibrated version of the model to answer, quantitatively, why have banks held onto a substantial increase in reserves while not increasing lending since 2008.