Miracle-dz/UniFAR-FTUs huggingface dataset:
Whole-brain analysis of amyotrophic lateral sclerosis by using echo-planar spectroscopic imaging.

PURPOSE To detect regional metabolic differences in amyotrophic lateral sclerosis (ALS) with whole-brain echo-planar spectroscopic imaging. MATERIALS AND METHODS Sixteen patients with ALS (nine men, seven women; mean age, 56.6 years), five persons suspected of having ALS (four men, one woman; mean age, 62.6 years), and 10 healthy control subjects (five men, five women; mean age, 56.1 years) underwent echo-planar spectroscopic imaging after providing informed consent. The study was approved by the institutional review board and complied with HIPAA. Data were analyzed with the Metabolic Imaging and Data Analysis System software, and processed metabolite maps were coregistered and normalized to a standard brain template. Metabolite maps of creatine (Cr), choline (Cho), and N-acetylaspartate (NAA) were segmented into 81 regions with Automated Anatomical Labeling software to measure metabolic changes throughout the brains of patients with ALS. Statistical analysis involved an unpaired, uncorrected, two-sided Student t test. RESULTS The NAA/Cho ratio across six regions was significantly lower by a mean of 23% (P ≤ .01) in patients with ALS than in control subjects. These regions included the caudate, lingual gyrus, supramarginal gyrus, and right and left superior and right inferior occipital lobes. The NAA/Cr ratio was significantly lower (P ≤ .01) in eight regions in the patient group, by a mean of 16%. These included the caudate, cuneus, frontal inferior operculum, Heschl gyrus, precentral gyrus, rolandic operculum, and superior and inferior occipital lobes. The Cho/Cr ratio did not significantly differ in any region between patient and control groups. CONCLUSION Whole-brain echo-planar spectroscopic imaging permits detection of regional metabolic abnormalities in ALS, including not only the motor cortex but also several other regions implicated in ALS pathophysiologic findings.
Characterization of Candle Flames

Common household open flame and radiant ignition sources are the actual or suspected cause for many fires. The purpose of this research is to identify the burning behavior and properties of common candles in order to provide additional tools for use by fire investigators. The properties of paraffin wax are obtained from the literature and from experiments. The candles are burned under controlled laboratory conditions to measure the mass burning rate, candle regression rate, flame height, and heat flux. Using the properties of paraffin wax and characteristics of the candles, numerous simulations are performed with the NIST Fire Dynamics Simulator (FDS) to model the burning rate and heat flux profile of the candle flame. The modeling results are then compared with the flame height and heat flux data obtained experimentally. The model facilitates an enhanced understanding of the structure of candle flames.
The significance of thermodynamic models in the accuracy improvement of RNA secondary structure prediction using permutation-based simulated annealing

Ribonucleic acid, a single stranded linear molecule, is essential to all biological systems. Different regions of the same RNA strand will fold together via base pair interactions to make intricate secondary and tertiary structures that guide crucial homeostatic processes in living organisms. Since the structure of RNA molecules is key to their function, algorithms for the prediction of RNA structure are of great value. This paper discusses significant improvements made to SARNA-Predict, an RNA secondary structure prediction algorithm based on Simulated Annealing (SA). One major improvement is the incorporation of a sophisticated thermodynamic model (efn2). This model is used by mfold to rank sub-optimal structures, but cannot be used directly by mfold during the structure prediction. Experiments on eight individual known structures from four RNA classes (5S rRNA, Group I intron 23S rRNA, Group I intron 16S rRNA and 16S rRNA) were performed. The data demonstrate the robustness and the effectiveness of our improved prediction algorithm. The new algorithm shows results which surpass the dynamic programming algorithm mfold in terms of prediction accuracy on all tested structures.
Posterior Body Surface Potential Mapping Using Capacitive-Coupled Electrodes and Its Application

Using 49 capacitive-coupled electrodes, mattress-type harness was developed to obtain posterior body surface potential map (P-BSPM) in dressed individuals. The aim of this study was to investigate how valuable information P-BSPM could provide, especially in discrimination of old myocardial infarction (OMI). P-BSPM of 59 individuals were analyzed; 23 normal control, 11 right bundle branch block (RBBB), 3 left bundle branch block (LBBB) and 19 OMI patients. Principal component analysis and linear hyper-plane approach were used to evaluate diagnostic performance. The axes of P-BSPM vector potential corresponded well with 12-lead electrocardiogram. During QRS, the end point of P-BSPM vector potential demonstrated characteristic clockwise rotation in RBBB, and counterclockwise rotation in LBBB patients. In OMI, initial negativity on P-BSPM during QRS was more frequently located at lower half, and also stronger in patients with inferior myocardial infarction (MI). The area under the receiver-operating characteristic curve of P-BSPM during QRS in diagnosing overall OMI, anterior MI, and inferior MI was 0.83 (95% confidence interval, 0.70-0.97), 0.71 (0.47-0.94), and 0.98 (0.94-1.0), respectively (P = 0.022 for anterior vs inferior MI groups). In conclusion, the novel P-BSPM provides detailed information for cardiac electrical dynamics and is applicable to diagnosing OMI, especially inferior myocardial infarction.
Can We All Get Along? How College Impacts Students' Sense of the Importance of Promoting Racial Understanding. ASHE Annual Meeting Paper.

This study, using data collected from 18,817 college students by the American Council on Education and the Higher Education Research Institute, addresses the extent to which college impacts students' sense of the importance of promoting racial understanding. Multiple regression analysis is used to study the manner in which various background characteListics, experiences, involvements, and college characteristics are related to the development of this particular attitude toward diversity. Specifically, the development of this attitude is mediated by many variables that are independent of the student's race, or any other background characteristics, and almost entirely dependent on the sorts of activities and courses she or he elects. These findings strongly support the notion that students' college activities, courses, and involvements are highly predictive of attitude formation regarding issues of diversity, even after controlling for other influences--a finding that provides support for the injection of ethnic/gender studies courses into the curriculum, and the provision of venues for the discussion of diversity issues. Contains 11 references. (Author/GLR) */:********************************************************************* Reproductions supplied by EDRS are the best that can be made from the original document. *********************************************************************** Promoting Racial Understanding 1 Can We All Get Along? How College Impacts Students' Sense of the Importance of Promoting Racial Understanding Jim Antony Graduate School of Education University of California, Los Angeles 'PERMISSION TO REPRODUCE THIS MATERIAL HAS BEEN GRANTED BY
Resilin in dragonfly and damselfly wings and its implications for wing flexibility

Although there is mounting evidence that passive mechanical dynamics of insect wings play an integral role in insect flight, our understanding of the structural details underlying insect wing flexibility remains incomplete. Here, we use comparative morphological and mechanical techniques to illuminate the function and diversity of two mechanisms within Odonata wings presumed to affect dynamic wing deformations: flexible resilin vein‐joints and cuticular spikes. Mechanical tests show that joints with more resilin have lower rotational stiffness and deform more in response to a load applied to an intact wing. Morphological studies of 12 species of Odonata reveal that resilin joints and cuticular spikes are widespread taxonomically, yet both traits display a striking degree of morphological and functional diversity that follows taxonomically distinct patterns. Interestingly, damselfly wings (suborder Zygoptera) are mainly characterized by vein‐joints that are double‐sided (containing resilin both dorsally and ventrally), whereas dragonfly wings (suborder Epiprocta) are largely characterized by single‐sided vein‐joints (containing resilin either ventrally or dorsally, but not both). The functional significance and diversity of resilin joints and cuticular spikes could yield insight into the evolutionary relationship between form and function of wings, as well as revealing basic principles of insect wing mechanical design. J. Morphol. , 2011. © 2011 Wiley‐Liss, Inc.
Signal Reconstruction Framework Based On Projections Onto Epigraph Set Of A Convex Cost Function (PESC)

A new signal processing framework based on making orthogonal Projections onto the Epigraph Set of a Convex cost function (PESC) is developed. In this way it is possible to solve convex optimization problems using the well-known Projections onto Convex Set (POCS) approach. In this algorithm, the dimension of the minimization problem is lifted by one and a convex set corresponding to the epigraph of the cost function is defined. If the cost function is a convex function in $R^N$, the corresponding epigraph set is also a convex set in R^{N+1}. The PESC method provides globally optimal solutions for total-variation (TV), filtered variation (FV), L_1, L_2, and entropic cost function based convex optimization problems. In this article, the PESC based denoising and compressive sensing algorithms are developed. Simulation examples are presented.
Novel low power pipelined FFT based on subexpression sharing for wireless LAN applications

This paper proposes a novel low power multiplierless radix-4 single-path delay commutator (R4SDC) FFT processor architecture for wireless LAN (IEEE 802.11 standard) applications, where short FFT are utilised in the implementation of the physical layer. The multiplierless architecture uses shift and addition operations to realize complex multiplications. By combining a new commutator architecture, and low power butterfly architectures with this approach, the resulting power savings are around 19% and 35% for 64-point and 16-point radix-4 FFT respectively, as compared to a conventional FFT architecture based on non-Booth coded Wallace tree multiplier.
Egg yolk environment differentially influences physiological and morphological development of broiler and layer chicken embryos

SUMMARY Maternal effects are important in epigenetic determination of offspring phenotypes during all life stages. In the chicken (Gallus gallus domesticus), transgenerational transfer of egg yolk factors may set the stage for morphological and physiological phenotypic differences observed among breeds. To investigate the effect of breed-specific yolk composition on embryonic broiler and layer chicken phenotypes, we employed an ex ovo, xenobiotic technique that allowed the transfer of broiler and layer chicken embryos from their natural yolks to novel yolk environments. Embryonic day two broiler embryos developing on broiler yolk culture medium (YCM) had significantly higher heart rates than layer embryos developing on layer YCM (176±7 beats min–1 and 147±7 beats min–1, respectively). Broiler embryos developing on layer YCM exhibited heart rates typical of layer embryos developing normally on layer YCM. However, layer embryo heart rates were not affected by development on broiler YCM. Unlike O2 consumption, development rate and body mass of embryos were significantly affected by exposure to different yolk types, with both broiler and layer embryos displaying traits that reflected yolk source rather than embryo genotype. Analysis of hormone concentrations of broiler and layer egg yolks revealed that testosterone concentrations were higher in broiler yolk (4.63±2.02 pg mg–1 vs 3.32±1.92 pg mg–1), whereas triiodothyronine concentrations were higher in layer yolk (1.05±0.18 pg mg–1 vs 0.46±0.22 pg mg–1). Thus, a complex synergistic effect of breed-specific genotype and yolk environment exists early in chicken development, with yolk thyroid hormone and yolk testosterone as potential mediators of the physiological and morphological effects.
Lacrimal Hypofunction as a New Mechanism of Dry Eye in Visual Display Terminal Users

Background Dry eye has shown a marked increase due to visual display terminal (VDT) use. It remains unclear whether reduced blinking while focusing can have a direct deleterious impact on the lacrimal gland function. To address this issue that potentially affects the life quality, we conducted a large-scale epidemiological study of VDT users and an animal study. Methodology/Principal Findings Cross sectional survey carried out in Japan. A total of 1025 office workers who use VDT were enrolled. The association between VDT work duration and changes in tear film status, precorneal tear stability, lipid layer status and tear secretion were analyzed. For the animal model study, the rat VDT user model, placing rats onto a balance swing in combination with exposure to an evaporative environment was used to analyze lacrimal gland function. There was no positive relationship between VDT working duration and change in tear film stability and lipid layer status. The odds ratio for decrease in Schirmer score, index of tear secretion, were significantly increased with VDT working year (P = 0.012) and time (P = 0.005). The rat VDT user model, showed chronic reduction of tear secretion and was accompanied by an impairment of the lacrimal gland function and morphology. This dysfunction was recovered when rats were moved to resting conditions without the swing. Conclusions/Significance These data suggest that lacrimal gland hypofunction is associated with VDT use and may be a critical mechanism for VDT-associated dry eye. We believe this to be the first mechanistic link to the pathogenesis of dry eye in office workers.
A Polynomial Solution to the Undirected Two Paths Problem

Given an undirected graph G = (V, E) and vertices s, , t t ; s2,t2, the problem is to determine whether or not G admits two vertex disjoint paths P, and P2 connecting s, with t, and s2 with t2, respectively. This problem is solved by an O ( n . m ) algorithm (n = IVJ, m = JElL An important by-product of the paper is a theorem stating that if G is 4-connected and nonplanar, then such paths P, and P2 exist for any choice of s,, s2, h, and t2 (as conjectured by Watkins).
Age-Rotation-Activity Relations for M Dwarf Stars Based on ASAS Photometric Data

Based on analysis of photometric observations of nearby M type stars obtained with ASAS, 31 periodic variables were detected. The determined periods are assumed to be related to rotation periods of the investigated stars. Among them 10 new variables with periods longer than 10 days were found, which brings the total number of slowly rotating M stars with known rotation periods to 12 objects. X-ray activity and rotation evolution of M stars follows the trends observed in G-K type stars. Rapidly rotating stars are very active and activity decreases with increasing rotation period but the period-activity relation is mass-dependent which suggests that the rotation period alone is not a proper measure of activity. The investigated stars were grouped according to their mass and the empirical turnover time was determined for each group. It increases with decreasing mass more steeply than for K type stars for which a flat dependence had been found. The resulting Rossby number-activity relation shows an exponential decrease of activity with increasing Rossby number. The analysis of space motions of 27 single stars showed that all rapidly rotating and a few slowly rotating stars belong to young disk (YD) whereas all old disk (OD) stars are slowly rotating. The median rotation period of YD stars is about 2 days and that of OD stars is equal to 47 days, i.e. nearly 25 times longer. The average X-ray flux of OD stars is about 1.7 dex lower than YD stars in a good agreement with the derived Rossby number-activity formula supplemented with rotation-age relation and in a fair agreement with recent observations but in a disagreement with the Skumanich formula supplemented with the activity-rotation relation.
Effect of Prayer and “OM” Meditation in Enhancing Galvanic Skin Response

The research was conducted with the purpose to study the effect of prayer and meditation on galvanic skin response (GSR). It was hypothesized that there was a significant positive effect of prayer and meditation (Om chanting) on galvanic skin response (GSR). The sample consisted of 20 normal, healthy female participants through purposive sampling. The age group of the sample was 18 to 24 years (Mean= 18.7, SD= 1.55). Gender was female and minimum education was graduation. The daily practice time of prayer and meditation session was 30 minutes for one month. Pre- Post data were recorded before and after intervention of prayer and meditation session by using single group pre-post research design. Recordings of galvanic skin response (GSR) were made on a computerized polygraph (Model Physiopac, PP 4, Medicaid Systems, Chandigarh, India) test. The results revealed a significant increase in GSR values as an effect of prayer and meditation which suggested the psychophysiological relaxation. Practicing prayer and meditation increases the galvanic skin response and hence decreases the stress level of the individual. Language: English
Short article: Does conspicuity enhance distraction? Saliency and eye landing position when searching for objects

While visual saliency may sometimes capture attention, the guidance of eye movements in search is often dominated by knowledge of the target. How is the search for an object influenced by the saliency of an adjacent distractor? Participants searched for a target amongst an array of objects, with distractor saliency having an effect on response time and on the speed at which targets were found. Saliency did not predict the order in which objects in target-absent trials were fixated. The within-target landing position was distributed around a modal position close to the centre of the object. Saliency did not affect this position, the latency of the initial saccade, or the likelihood of the distractor being fixated, suggesting that saliency affects the allocation of covert attention and not just eye movements.
Supermassive black hole mass measurements for NGC 1300 and 2748 based on Hubble Space Telescope emission‐line gas kinematics

We present Space Telescope Imaging Spectrograph emission-line spectra of the central regions of the spiral galaxies NGC 1300 and 2748. From the derived kinematics of the nuclear gas we have found evidence for central supermassive black holes in both galaxies. The estimated masses of the black holes in NGC 1300 and 2748 are (6.6 +6.3) × 10 7 and (4.4 +3.5) × 10 7 M� , respectively (both at the 95 per cent confidence level). These two black hole mass estimates contribute to the poorly sampled low-mass end of the nuclear black hole mass spectrum. Ke yw ords: black hole physics ‐ galaxies: individual: NGC 1300 ‐ galaxies: individual: NGC 2748 ‐ galaxies: kinematics and dynamics ‐ galaxies: nuclei ‐ galaxies: spiral.
On the Effect of Skewness and Kurtosis Misspecification on the Hedging Error

Using a result in Angelini and Herzel (2009a), we measure, in terms of variance, the cost of hedging a contingent claim when the hedging portfolio is re-balanced at a discrete set of dates. We analyse the dependence of the variance of the hedging error on the skewness and kurtosis as modeled by a Normal Inverse Gaussian model. We consider two types of strategies, the standard Black-Scholes Delta strategy and the locally variance-optimal strategy, and we perform some robustness tests. In particular, we investigate the effect of different types of model misspecification on the performance of the hedging, like that of hedging without taking skewness into account. Computations are performed using a Fast Fourier Transform approach.
Prevalence of qnr and aac(6’)-Ib-cr Genes in Clinical Isolates of Klebsiella Pneumoniae from Imam Hussein Hospital in Tehran

Background: Plasmid mediated quinolone resistance (PMQR) has been shown to play an important role in resistance not only to quinolones, but also β-lactams and aminoglycosides. In fact, qnr genes are frequently carried along with β-lactamase determinants on the same plasmids. We studied the prevalence of qnrA, qnrB, qnrS and aac(6’)-Ib-cr genes among quinolone and cephalosporin resistant clinical isolates of Klebsiella pneumoniae (K. pneumoniae), as well as the association between PMQR genes with resistance to quinolones, cephalosporins and aminoglycosides. Methods: The study was conducted on 79 K. pneumoniae clinical isolates collected from Imam Hussein hospital in Tehran between July 2010 and January 2011, based on their resistance to quinilones and cephalosporins. Antibacterial susceptibility was determined to 15 antibiotics by disc diffusion. Presence of qnrA, qnrB, qnrS and aac(6’)-Ib-cr genes were investigated using specific primers and PCR. Results: Of the 79 K. pneumoniae isolates, 47 (59.5%) carried the PMQR determinants. Among these, 42 (89.4%) carried aac(6’)-Ib-cr of which, 21 (50%) also harbored qnrB. Three isolates carried qnrB alone, two (4.2%) harbored qnrS and none had qnrA. Resistance to aminoglycosides and cephalosporins was significantly higher in the isolates carrying both qnrB and aac(6’)-Ib-cr genes compared to aac(6’)-Ib-cr alone. Conclusion: This study showed a high prevalence of aac(6’)-Ib-cr and qnrB genes among the Iranian K. pneumoniae clinical isolates as well as co-carriage of the two genes. There was a significant association between qnrB gene carriage and resistance to quinolones, cephalosporins, and aminoglycosides.
Digital daily cycles of individuals

Humans, like almost all animals, are phase-locked to the diurnal cycle. Most of us sleep at night and are active through the day. Because we have evolved to function with this cycle, the circadian rhythm is deeply ingrained and even detectable at the biochemical level. However, within the broader day-night pattern, there are individual differences: e.g., some of us are intrinsically morning-active, while others prefer evenings. In this article, we look at digital daily cycles: circadian patterns of activity viewed through the lens of auto-recorded data of communication and online activity. We begin at the aggregate level, discuss earlier results, and illustrate differences between population-level daily rhythms in different media. Then we move on to the individual level, and show that there is a strong individual-level variation beyond averages: individuals typically have their distinctive daily pattern that persists in time. We conclude by discussing the driving forces behind these signature daily patterns, from personal traits (morningness/eveningness) to variation in activity level and external constraints, and outline possibilities for future research.
Measurable Quality Characteristics of a Software System on Software Architecture Level

main purpose of most software produces, into present a software system with high quality. Most of the experts believe that to achieve this subject, performing all of the stages of producing the software must be based on qualitative programming and performing prepuces. These points specially in producing the software architecture as one of the most important stages of this process must be considered more carefully. Regarding to different and various definitions for quality and architecture of software, this essay must at first investigate these two matters and there based on achieved results, determine the Evaluable qualitative characteristics at the architecture level.