Miracle-dz/UniFAR-FTUs huggingface dataset:
Knowledge Spillovers and Firm Size Heterogeneity

This paper explains two data facts related to rm size distribution. First, it uses sector-speci c inter- rm knowledge spillovers to explain the sectoral di¤erences in rm size heterogeneity. I formalize an environment in which greater inter- rm knowledge spillovers in a sector induce rms in that sector to invest relatively more in imitation. This implies that imitation contributes a greater share to rm growth rates in these sectors. Greater imitation also causes faster catch-up by lagging rms and declining rm growth rate with rm size. Hence, the sectoral rm size distribution becomes more homogeneous in the sectors with greater knowledge spillovers. Second, in a multi-sector version of this environment, I use inter-sector knowledge spillovers to explain the observed dependent Pareto3 size distributions in every subset of the economy. I test the model using patent citation data and nd support for both its sectoral and aggregate predictions. JEL Classi cation: O33 O41 L11 L6 Keywords: inter- rm knowledge spillovers, rm size heterogeneity, sectoral di¤erences, scale-dependent rm growth rate, inter-sector knowledge spillover, Pareto distribution
Conundrums of Integration

Recent scholarly and public conversations have given renewed attention to integration as a goal, an aspiration, and/or an “imperative. ” These calls for integration are infused with the conviction that segregation is a linchpin, if not the linchpin, of persistent racialized hierarchies. While the costs of persistent segregation remain clear, the call for integration as the unequivocal answer is more contested. In this article we grapple with some of these conundrums of integration, asking whether, in fact, integration furthers equity and if not, why not? To explore this issue we focus on an “integrated” space—Riverview, a successful high school known for its diversity—and drawing on theory from social psychology, we show how the promise of integration in such contexts is undermined. We conclude that while integration may well be a necessary condition to advance equity, it is not by itself a sufficient condition to ensure it.
Selective action of myasthenic syndrome antibodies on calcium channels in a rodent neuroblastoma x glioma cell line.

1. The effect of Lambert‐Eaton myasthenic syndrome (LEMS) immunoglobulin G (IgG) on Ca2+ channels in undifferentiated mouse neuroblastoma x rat glioma hybrid cells (NG 108 15) was studied using the whole‐cell patch clamp technique. 2. Sustained inward Ca2+ channel currents were evoked by depolarizing pulses from holding potentials of ‐80 and ‐40 mV, and were blocked by 5 microM‐nitrendipine (L‐type currents). Transient inward Ca2+ channel currents were activated from a holding potential of ‐80 mV by small depolarizing steps (T‐type currents). Noradrenaline (10 microM) was without effect on transient currents. 3. LEMS IgG selectively reduced sustained (L‐type) Ca2+ channel current amplitudes evoked from either holding potential used. In the presence of nitrendipine (5 microM), there was no significant effect of LEMS IgG on the remaining transient (T‐type) Ca2+ channel current amplitudes. 4. Studies of the potential for maximal inward current indicated that voltage sensitivities of both L‐ and T‐type Ca2+ channel current amplitudes were unaffected by LEMS IgG, whether recorded in the presence or absence of nitrendipine. LEMS IgG had no significant effect on the time‐to‐peak or decay of Ca2+ channel currents. 5. It is concluded that LEMS IgG acts selectively to cause functional loss of L‐type, but not T‐type, Ca2+ channels in NG 108 15 cells. Any effect of LEMS IgG on N‐type channels (not present in these undifferentiated cells) was not studied here. LEMS IgG also acts at motor nerve terminal Ca2+ channels leading to muscle weakness. Thus antigenic similarities must exist between L‐type channels in NG 108 15 cells and Ca2+ channels at motor nerve terminals.
Analysis of CEA expression and EGFR mutation status in non-small cell lung cancers.

BACKGROUND The serum carcinoembryonic antigen (CEA) level can reflect tumor growth, recurrence and metastasis. It has been reported that epidermal growth factor receptor (EGFR) mutations in exons 19 and 21 may have an important relationship with tumor cell sensitivity to EGFR -TKI therapy. In this study, we investigated the clinical value of EGFR mutations and serum CEA in patients with non-small cell lung cancer (NSCLC). MATERIALS AND METHODS The presence of mutations in EGFR exons 19 and 21 in the tissue samples of 315 patients with NSCLC was detected with real-time fluorescent PCR technology, while the serum CEA level in cases who had not yet undergone surgery, radiotherapy, chemotherapy and targeted therapy were assessed by electrochemical luminescence. RESULTS The mutation rates in EGFR exons 19 and 21 were 23.2% and 14.9%, respectively, with the two combined in 3.81%. Measured prior to the start of surgery, radiotherapy, chemotherapy and targeted treatment, serum CEA levels were abnormally high in 54.3% of the patients. In those with a serum CEA level <5 ng/mL, the EGFR mutation rate was 18.8%, while with 5~19 ng/mL and ≥ 20 ng/mL, the rates were 36.4% and 62.5%. In addition, in the cohort of patients with the CEA level being 20~49 ng/mL, the EGFR mutation rate was 85.7%, while in those with the CEA level ≥ 50 ng/mL, the EGFR mutation rate was only 20.0%, approximately the same as in cases with the CEA level<5 ng/mL. CONCLUSIONS There is a positive correlation between serum CEA expression level and EGFR mutation status in NSCLC patients, namely the EGFR mutation-positive rate increases as the serum CEA expression level rises within a certain range (≥ 20 ng/mL, especially 20~49 ng/mL). If patient samples are not suitable for EGFR mutation testing, or cannot be obtained at all, testing serum CEA levels might be a simple and easy screening method. Hence, for the NSCLC patients with high serum CEA level (≥ 20 ng/mL, especially 20~49 ng/mL), it is worthy of attempting EGFR-TKI treatment, which may achieve better clinical efficacy and quality of life.
Body Movements: An Important Additional Factor in Discriminating Pain From Stress in Preterm Infants

Objectives:To describe developmentally appropriate, specific body movements and other biobehavioral responses of preterm infants to a group of routine care giving tasks (Clustered Care), and to compare responses to acute pain with those of Clustered Care. Methods:In a randomized design, 54 preterm infants were assessed at 32 weeks gestational age during 3 phases of blood collection (Baseline, Lance/squeeze, Recovery) and of diaper changing, measuring abdominal girth and axillary temperature, and mouth care (Baseline, Clustered Care, Recovery) in a neonatal intensive care unit. The Newborn Individualized Developmental Care and Assessment Program and 1 facial action from the Neonatal Facial Coding System, Brow Bulge, were coded from separate continuous bedside video recordings. Heart rate and oxygen saturation were also acquired continuously. Results:Brow Bulge, heart rate, and a subset of 9 Newborn Individualized Developmental Care and Assessment Program movements increased and oxygen saturation decreased significantly to Lance/squeeze compared to Baseline. Similar facial and physiological changes occurred during Clustered Care, but with less intensity. However, infants showed greater frequencies and variety of Newborn Individualized Developmental Care and Assessment Program stress cues during Clustered Care than during Lance/squeeze. Stress cues persisted after Clustered Care, whereas the infants returned to Baseline following Lance/squeeze. Discussion:Changes in facial activity and heart rate remain the most sensitive markers of pain in preterm infants. Tactile procedures, such as diaper changing, produce lower intensity facial and physiological responses than pain procedures, but greater body reactions. Also, the effects from tactile procedures appear to last longer. Adding observations of a small number of specific body movements to the assessment of pain and stress provides complementary information particularly for those infants who may show dampened facial reactivity as a result of repeated pain exposure.
On the Rational Choice Theory of Voter Turnout

I consider a two-candidate election in which there is aggre- gate uncertainty about the popularity of each candidate, where voting is costly, and where participants are instrumentally motivated. The unique equilibrium predicts substantial turnout under reasonable pa- rameter configurations, and greater turnout for the apparent underdog offsets the expected advantage of the perceived leader. I also present clear predictions about the response of turnout and the election outcome to various parameters, including the importance of the election; the cost of voting; the perceived popularity of each candidate; and the accuracy of pre-election information sources, such as opinion polls.
Circular Structures in Retroviral and Cellular Genomes (*)

A computer program for predicting DNA bending from nucleotide sequence was used to identify circular structures in retroviral and cellular genomes. An 830-base pair circular structure was located in a control region near the center of the genome of the human immunodeficiency virus type I (HIV-I). This unusual structure displayed relatively smooth planar bending throughout its length. The structure is conserved in diverse isolates of HIV-I, HIV-II, and simian immunodeficiency viruses, which implies that it is under selective constraints. A search of all sequences in the GenBank data base was carried out in order to identify similar circular structures in cellular DNA. The results revealed that the structures are associated with a wide range of sequences that undergo recombination, including most known examples of DNA inversion and subtelomeric translocation systems. Circular structures were also associated with replication and transposition systems where DNA looping has been implicated in the generation of large protein-DNA complexes. Experimental evidence for the structures was provided by studies which demonstrated that two sequences detected as circular by computer preferentially formed covalently closed circles during ligation reactions in vitro when compared to nonbent fragments, bent fragments with noncircular shapes, and total genomic DNA. In addition, a single T C substitution in one of these sequences rendered it less planar as seen by computer analysis and significantly reduced its rate of ligase-catalyzed cyclization. These results permit us to speculate that intrinsically circular structures facilitate DNA looping during formation of the large protein-DNA complexes that are involved in site- and region-specific recombination and in other genomic processes.
Reining in the web with content security policy

The last three years have seen a dramatic increase in both awareness and exploitation of Web Application Vulnerabilities. 2008 and 2009 saw dozens of high-profile attacks against websites using Cross Site Scripting (XSS) and Cross Site Request Forgery (CSRF) for the purposes of information stealing, website defacement, malware planting, clickjacking, etc. While an ideal solution may be to develop web applications free from any exploitable vulnerabilities, real world security is usually provided in layers. We present content restrictions, and a content restrictions enforcement scheme called Content Security Policy (CSP), which intends to be one such layer. Content restrictions allow site designers or server administrators to specify how content interacts on their web sites-a security mechanism desperately needed by the untamed Web. These content restrictions rules are activated and enforced by supporting web browsers when a policy is provided for a site via HTTP, and we show how a system such as CSP can be effective to lock down sites and provide an early alert system for vulnerabilities on a web site. Our scheme is also easily deployed, which is made evident by our prototype implementation in Firefox and on the Mozilla Add-Ons web site.
The suggestibility of boys and girls between the ages of six and sixteen years.

* Recommended by Clark L. Hull and accepted for publication by Carl Murchison of the Editorial Board. 1 The writer wishes to express her gratitude to Professor Henry H. Goddard, who proposed the study and furnished helpful advice; to Professor Francis N. Maxfield, who directed the work and gave generous assistance; and to Professor Clark L. Hull, who offered certain suggestions concerning the interpretation of the data.
Granularity-Aware Work-Stealing for Computationally-Uniform Grids

Good scheduling is important for ensuring effective use of Grid resources, while maximising parallel performance. In this paper, we show how a basic ``Random-Stealing'' load balancing algorithm for computational Grids can be improved by using information about the task granularity of parallel programs. We propose several strategies (SSL, SLL and LLL) for using granularity information to improve load balancing, presenting results both from simulations and from a real implementation (the Grid-GUM Runtime System for Parallel Haskell). We assume a common model of task creation which subsumes both master/worker and data-parallel programming paradigms under a task-stealing work distribution strategy. Overall, we achieve improvement in runtime of up to 19.4% for irregular problems in the real implementation, and up to 40% for the simulations (typical improvements of more that 15% for irregular programs, and from 5-10% for regular ones). Our results show that, for computationally-uniform Grids, advanced load balancing methods that exploit granularity information generally have the greatest impact on reducing the runtimes of irregular parallel programs. Moreover, the more irregular the program is, the better the improvements that can be achieved.
Recombinant Human Activated Protein C in the Treatment of Acute Respiratory Distress Syndrome: A Randomized Clinical Trial

Rationale Pulmonary coagulopathy may play a pathogenetic role in acute respiratory distress syndrome (ARDS), by contributing to alveolocapillary inflammation and increased permeability. Recombinant human activated protein C (rh-APC) may inhibit this process and thereby improve patient outcome. Methods A prospective randomized, saline-controlled, single-blinded clinical trial was performed in the intensive care units of two university hospitals, and patients with ARDS were included within 24 h after meeting inclusion criteria. Intervention A 4-day course of intravenous rh-APC (24 mcg/kg/h) (n = 33) versus saline (n = 38). Outcomes The primary outcome parameter was the pulmonary leak index (PLI) of 67Gallium-transferrin as a measure of alveolocapillary permeability and secondary outcomes were disease severity scores and ventilator-free days, among others. Results Baseline characteristics were similar; in 87% of patients the PLI was above normal and in 90% mechanical or non-invasive ventilation was instituted at a median lung injury score of 2.5. There was no evidence that Rh-APC treatment affected the PLI or attenuated lung injury and sequential organ failure assessment scores. Mean ventilator-free days amounted to 14 (rh-APC) and 12 days (saline, P = 0.35). 28-day mortality was 6% in rh-APC- and 18% in saline-treated patients (P = 0.12). There was no difference in bleeding events. The study was prematurely discontinued because rh-APC was withdrawn from the market. Conclusion There is no evidence that treatment with intravenous rh-APC during 4 days for infectious or inflammatory ARDS ameliorates increased alveolocapillary permeability or the clinical course of ARDS patients. We cannot exclude underpowering. Trial Registration Nederlands Trial Register ISRCTN 52566874
The Reactive Tabu Search

We propose an algorithm for combinatorial optimization where an explicit check for the repetition of configurations is added to the basic scheme of Tabu search. In our Tabu scheme the appropriate size of the list is learned in an automated way by reacting to the occurrence of cycles. In addition, if the search appears to be repeating an excessive number of solutions excessively often, then the search is diversified by making a number of random moves proportional to a moving average of the cycle length. The reactive scheme is compared to a “strict” Tabu scheme that forbids the repetition of configurations and to schemes with a fixed or randomly varying list size. From the implementation point of view we show that the Hashing or Digital Tree techniques can be used in order to search for repetitions in a time that is approximately constant. We present the results obtained for a series of computational tests on a benchmark function, on the 0-1 Knapsack Problem, and on the Quadratic Assignment Problem. INFORMS Journal on Computing , ISSN 1091-9856, was published as ORSA Journal on Computing from 1989 to 1995 under ISSN 0899-1499.
An Artificial Language Evaluation of Distributional Semantic Models

Recent studies of distributional semantic models have set up a competition between word embeddings obtained from predictive neural networks and word vectors obtained from abstractive count-based models. This paper is an attempt to reveal the underlying contribution of additional training data and post-processing steps on each type of model in word similarity and relatedness inference tasks. We do so by designing an artificial language framework, training a predictive and a count-based model on data sampled from this grammar, and evaluating the resulting word vectors in paradigmatic and syntagmatic tasks defined with respect to the grammar.
Influence of the Selection Level, Age and Playing Position on Relative Age Effects in Swiss Women's Soccer

Relative age effects (RAEs) refer to age differences in the same selection year. In this study, 6,229 female soccer players representing the entire Swiss female soccer population were evaluated to determine the prevalence of RAEs in Swiss women's soccer. Significant RAEs existed in the self-selected extracurricular (n = 2987) soccer teams and the subgroup of talent development teams (n = 450) in the 10 to14 age category. No significant RAEs were found for players 15 years of age or older (n = 3242) and the subgroup of all national teams (n = 239). Additionally, significantly stronger RAEs were observed in defenders and goalkeepers compared to midfielders in national teams. Our findings show that in Switzerland, RAEs apparently influence the self selection and talent selection processes of women's soccer in the 10 to 14 age category. However, in contrast to male soccer we found no RAEs in elite women's soccer teams.
Relational Environment and Intellectual Roots of 'Ecological Economics': An Orthodox or Heterodox Field of Research?

The way the fields are delineated has been the Achilles' heel of studies analyzing the status and evolution of given scientific areas. Based on van den Besselaar and Leydesdorff's (Mapping change in scientific specialities; a scientometric reconstruction of the development of artificial intelligence, 1996) contribution, the authors propose a systematic and objective method for delineating the field of ecological economics assuming that aggregated journal-journal citation relations is an appropriate indicator for the disciplinary organization of the sciences. They found that the relational scientific backbone of ecological economics comprises 7 main journals: American Journal of Agricultural Economics, Ecological Economics, Environment and Development Economics, Environmental and Resources Economics, Land Economics, Land Use Policy, and Journal of Environmental Economics and Management. From the 3727 articles published between 2005 and 2010 in the ecological economics field, and the corresponding 142 thousand citations two main outcomes emerged: 1) the intellectual frame of reference is overwhelmed by economists and environmental and resources economists with (renowned) ecological economists relatively underrepresented; 2) the building of an integrative knowledge domain is not apparent: on the one hand, ecological economics is seen to be an 'unbound' heterodox and multidisciplinary field, but on the other hand, and somewhat awkwardly, it is (still) heavily 'bound' by quantitative mainstream/ orthodox methodologies.
In Situ Complex Systems of Drug and Organic Electrolyte for Extended Release Tablets Using HPC

In situ drug and organic electrolyte complex tablets were investigated as extended release dosage forms. Incor- porating a 1:1 molar ratio of diltiazem HCl and an anionic organic electrolyte (i.e., Na deoxycholate) into HPC tablets ex- tended the total release time with a near zero - order release rate (release exponent, n = 0.85 - 0.97) due to in situ complex formation of the drug and the organic electrolyte. When the molar ratio was less than 1 (e.g., 0.5), drug release was faster and the effect of drug diffusion was only slightly observable with n = 0.82 due to the availability of uncomplexed free drug to diffuse out of the swollen HPC gel layer. Little effect was observed for the type of amine in the drug or drug solu- bility on release kinetics for diltiazem HCl, verapamil HCl, and propranolol HCl. Benzathine diacetate was used as the or- ganic electrolyte, in situ complexing agent for anionic drugs (e.g., Na salicylate). Even though the total extended release time was increased from 500 min to 1600 min, drug release kinetics for the in situ salicylate benzathine complex HPC tab- lets (n = 0.54 - 0.59) was not much improved compared to those of Na salicylate HPC tablets (0.40 - 0.41). Anionic drugs with low solubility (e.g., naproxen Na and tolmetin Na) showed slightly sigmoidal release profiles with n = 1.09 and 1.13, respectively. No difference in release kinetics among different cationic organic electrolytes (e.g., benzathine diacetate, aminodiphenylmethane HCl, and N-benzyl-2-phenethylamine HCl) for Na salicylate was found. It was found that more linear release kinetics was obtained when organic electrolytes were present in tablets more than the amount required to form 1:1 complexes with oppositely charged drugs.
Elevated plasma osteopontin levels were associated with osteopontin expression of CD4+ T cells in patients with unstable angina.

BACKGROUND Plaque instability in patients with unstable angina (UA) is associated with stimulated CD4+ T cells, so the present study investigated whether there is a relationship among plaque instability, osteopontin and CD4+ T cells. METHODS AND RESULTS Peripheral blood mononuclear cells were collected from 51 consecutive patients with UA, 60 patients with stable angina (SA), and 39 patients with chest pain syndrome (CPS). Osteopontin-producing CD4+ T cells were quantified by flow cytometry. Plasma osteopontin levels (ng/ml) were measured by ELISA and were higher in patients with UA (792.0 +/- 316.7) than in those with SA (626.0 +/- 195.0, p < 0.005) or CPS (594.7 +/- 239.4, p < 0.005). The frequency (%) of osteopontin-producing CD4+ T cells was higher in patients with UA (26.7 +/- 13.3) than in those with SA (19.5 +/- 11.1, p < 0.05) or CPS (16.6 +/- 9.0, p < 0.005). Furthermore, the plasma osteopontin level correlated with the frequency of osteopontin-producing CD4+ T cells (r = 0.327, p = 0.0004), as did the high-sensitivity C-reactive protein level (r = 0.360, p = 0.0002). CONCLUSIONS The plasma osteopontin levels are elevated in patients with UA, accompanied by an increase in the number of osteopontin-production of circulating CD4+ T cells. Circulating CD4+ T cells may play a role through osteopontin in the pathophysiology of UA.