Miracle-dz/UniFAR-FTUs huggingface dataset:
Impaired insulin secretion and glucose tolerance in β cell‐selective CaV1.2 Ca2+ channel null mice

Insulin is secreted from pancreatic β cells in response to an elevation of cytoplasmic Ca2+ resulting from enhanced Ca2+ influx through voltage‐gated Ca2+ channels. Mouse β cells express several types of Ca2+ channel (L‐, R‐ and possibly P/Q‐type). β cell‐selective ablation of the gene encoding the L‐type Ca2+ channel subtype Cav1.2 (βCav1.2−/− mouse) decreased the whole‐cell Ca2+ current by only ∼45%, but almost abolished first‐phase insulin secretion and resulted in systemic glucose intolerance. These effects did not correlate with any major effects on intracellular Ca2+ handling and glucose‐induced electrical activity. However, high‐resolution capacitance measurements of exocytosis in single β cells revealed that the loss of first‐phase insulin secretion in the βCav1.2−/− mouse was associated with the disappearance of a rapid component of exocytosis reflecting fusion of secretory granules physically attached to the Cav1.2 channel. Thus, the conduit of Ca2+ entry determines the ability of the cation to elicit secretion.
The Partitioning of Poleward Heat Transport between the Atmosphere and Ocean

Abstract Observations of the poleward heat transport of the earth (H) suggest that the atmosphere is the primary transporting agent poleward of 30°, that oceanic (HO) and atmospheric (HA) contributions are comparable in the tropical belt, and that ocean transport dominates in the deep Tropics. To study the partition we express the ratio HA/HO as where Ψ (with subscripts A and O denoting atmosphere and ocean, respectively) is the meridional mass transport within θ layers (moist potential temperature for the atmosphere, potential temperature for the ocean), and CΔθ (C being the specific heat) is the change in energy across the circulation defined by Ψ. It is argued here that the observed partitioning of heat transport between the atmosphere and ocean is a robust feature of the earth's climate and reflects two limits: (i) dominance of atmospheric mass transport in mid-to-high latitudes (ΨA ≫ ΨO with CAΔθA ∼ COΔθO and hence HA/HO ≫ 1) and (ii) dominance of oceanic energy contrast in the Tropics (COΔθO ≫ CAΔθA.
Increased impulsivity in rats as a result of repeated cycles of alcohol intoxication and abstinence

Impulsivity is a risk factor for alcoholism, and long‐term alcohol exposure may further impair impulse control in a manner that propels problematic alcohol use. The present study employed the rat 5‐choice serial reaction time task (5‐CSRTT) to measure behavioral inhibition and attentional capacity during abstinence from repeated 5‐day cycles of alcohol liquid diet consumption. Task performance was not disrupted following the first cycle of alcohol exposure; however, evidence of impaired behavioral inhibition emerged following the third cycle of alcohol exposure. In comparison with controls, alcoholic rats exhibited deficits in inhibitory control during cognitively challenging 5‐CSRTT tests employing variable intertrial interval (varITI). This behavioral disruption was not present during early abstinence (3 days) but was evident by 7 days of abstinence and persisted for at least 34 days. Interestingly, renewed alcohol consumption ameliorated these disruptions in impulse control, although deficient behavioral inhibition re‐emerged during subsequent abstinence. Indices of increased impulsivity were no longer present in tests conducted after 49 days of abstinence. Alcohol‐related impairments in impulse control were not evident in sessions employing highly familiar task parameters regardless of the abstinence period, and control experiments confirmed that performance deficits during the challenge sessions were unlikely to result from alcohol‐related disruption in the adaptation to repeated varITI testing. Together, the current findings demonstrate that chronic intermittent alcohol consumption results in decreased behavioral inhibition in rats that is temporally similar to clinical observations of disrupted impulsive control in abstinent alcoholics performing tasks of behavioral inhibition.
Constrained data-driven controller tuning for nonlinear systems

This paper proposes a data-driven algorithm that solves an optimal control problem by iteratively tuning the controller. The data-driven algorithm solves the optimization problem for a nonlinear process with a linear controller, accounting for operational constraints and employing an interior-point barrier (IPB) algorithm. The search process in the IPB algorithm requires first-order information which is generated using identified models via neural networks in order to reduce the number of experiments. A case study which deals with the angular position control of a nonlinear aerodynamic system is included to validate the new algorithm by simulation results.
Coding of Shape and Position in Macaque Lateral Intraparietal Area

The analysis of object shape is critical for both object recognition and grasping. Areas in the intraparietal sulcus of the rhesus monkey are important for the visuomotor transformations underlying actions directed toward objects. The lateral intraparietal (LIP) area has strong anatomical connections with the anterior intraparietal area, which is known to control the shaping of the hand during grasping, and LIP neurons can respond selectively to simple two-dimensional shapes. Here we investigate the shape representation in area LIP of awake rhesus monkeys. Specifically, we determined to what extent LIP neurons are tuned to shape dimensions known to be relevant for grasping and assessed the invariance of their shape preferences with regard to changes in stimulus size and position in the receptive field. Most LIP neurons proved to be significantly tuned to multiple shape dimensions. The population of LIP neurons that were tested showed barely significant size invariance. Position invariance was present in a minority of the neurons tested. Many LIP neurons displayed spurious shape selectivity arising from accidental interactions between the stimulus and the receptive field. We observed pronounced differences in the receptive field profiles determined by presenting two different shapes. Almost all LIP neurons showed spatially selective saccadic activity, but the receptive field for saccades did not always correspond to the receptive field as determined using shapes. Our results demonstrate that a subpopulation of LIP neurons encodes stimulus shape. Furthermore, the shape representation in the dorsal visual stream appears to differ radically from the known representation of shape in the ventral visual stream.
A Geometric Approach to Sample Compression

The Sample Compression Conjecture of Littlestone & Warmuth has remained unsolved for a quarter century. While maximum classes (concept classes meeting Sauer's Lemma with equality) can be compressed, the compression of general concept classes reduces to compressing maximal classes (classes that cannot be expanded without increasing VC dimension). Two promising ways forward are: embedding maximal classes into maximum classes with at most a polynomial increase to VC dimension, and compression via operating on geometric representations. This paper presents positive results on the latter approach and a first negative result on the former, through a systematic investigation of finite maximum classes. Simple arrangements of hyperplanes in hyperbolic space are shown to represent maximum classes, generalizing the corresponding Euclidean result. We show that sweeping a generic hyperplane across such arrangements forms an unlabeled compression scheme of size VC dimension and corresponds to a special case of peeling the one-inclusion graph, resolving a recent conjecture of Kuzmin & Warmuth. A bijection between finite maximum classes and certain arrangements of piecewise-linear (PL) hyperplanes in either a ball or Euclidean space is established. Finally we show that d-maximum classes corresponding to PL-hyperplane arrangements in Rd have cubical complexes homeomorphic to a d-ball, or equivalently complexes that are manifolds with boundary. A main result is that PL arrangements can be swept by a moving hyperplane to unlabeled d-compress any finite maximum class, forming a peeling scheme as conjectured by Kuzmin & Warmuth. A corollary is that some d-maximal classes cannot be embedded into any maximum class of VC-dimension d+k, for any constant k. The construction of the PL sweeping involves Pachner moves on the one-inclusion graph, corresponding to moves of a hyperplane across the intersection of d other hyperplanes. This extends the well known Pachner moves for triangulations to cubical complexes.
Influence of oxidation temperature and time on stresses in thermal barrier coated aerofoil sections

Abstract The influence of temperature and time of thermal exposure on the residual stresses developed within a thermal barrier coating (TBC) and the underlying thermally grown oxide (TGO) are investigated. Stress measurements on the TBC and the TGO for specimens with aerofoil geometry features were made at positions of fixed curvature using Raman spectroscopy and photo-stimulated piezoluminescence spectroscopy. The Raman shifts were converted to stress via a factor measured using a diamond anvil cell (DAC). The acquired stresses were shown to be tensile at all positions measured in the as-coated specimens, and change progressively from tensile to compressive with thermal exposure. Residual stresses within the TGO were found to be a function of the ageing temperature and time, substrate geometry and thickness of the TBC. The results are discussed with respect to the long term integrity of the coatings.
Tumor Inhibition by DepoVax-Based Cancer Vaccine Is Accompanied by Reduced Regulatory/Suppressor Cell Proliferation and Tumor Infiltration

A successful cancer vaccine needs to overcome the effects of immune-suppressor cells such as Treg lymphocytes, suppressive cytokine-secreting Tr1 cells, and myeloid-derived suppressor cells (MDSCs), while enhancing tumor-specific immune responses. Given the relative poor efficacy associated with current cancer vaccines, a novel vaccine platform called DepoVaxTM (DPX) was developed. C3 tumor-challenged mice were immunized with HPV-E7 peptide in DPX- or conventional-emulsion- (CE-) based vaccine. While control mice showed marked increase in Treg/MDSCs in spleen and blood, in mice treated with DPX-E7 the levels remained similar to tumor-free naive mice. Such differences were also seen within the tumor. Antigen-specific IL10-secreting CD4/CD8 T cells and TGF-β +CD8+ T cell frequencies were increased significantly in CE-treated and control mice in contrast to DPX-E7-immunized mice. Analysis of tumor-infiltrating cells revealed higher frequency of suppressor cells in untreated controls than in DPX-E7 group while the converse was true for tumor-infiltrating CD8 T cells. Immunization of tumor-bearing HLA-A2 transgenic mice with human vaccine DPX-0907, a peptide-based vaccine for breast/ovarian/prostate cancers, showed efficient induction of immune response to cancer peptides despite the presence of suppressor cells. Thus, this study provides the rationale for using DPX-based cancer vaccines in immune-suppressed cancer patients, to induce effective anticancer immunity.
Supplementary effects of higher levels of various disaccharides on processing yield, quality properties and sensory attributes of Chinese - style pork jerky

Objective This study evaluated the supplementary effect of higher concentrations of various disaccharides on processing yield, major physicochemical properties, and sensory attributes of Chinese-style pork jerky (CSPJ). Methods CSPJ samples were prepared by marinating sliced ham (4 mm) with three dissaccharides, including sucrose, lactose, and maltose, at 0%, 15%, 18%, 21%, and 24%. Subsequently, the CSPJ samples were dried and roasted. The moisture content, water activity, crude protein, moisture-to-protein ratio, pH, processing yield, shear force, color, and sensory attributes of the CSPJ samples were evaluated. Results The quality characteristics of CSPJ samples prepared with sucrose were more acceptable. By contrast, CSPJ samples prepared with lactose showed the lowest scores. However, the processing yield and moisture content were the highest for CSPJ samples prepared with lactose, which may be associated with improved benefits for cost reduction. Furthermore, sucrose and lactose supplementation resulted in contrasting quality characteristics; for example, CSPJ samples with sucrose and maltose supplementation had higher sensory scores for color than samples with lactose supplementation. Additionally, most quality characteristics of CSPJ samples with sucrose supplementation contrasted with those of the samples with lactose supplementation; for example, the samples with sucrose supplementation had higher scores for sensory attributes than those with lactose supplementation. Conclusion Sucrose supplementation up to 21% to 24% was associated with the highest overall acceptability scores (5.19 to 5.80), enhanced quality characteristics, increased processing yield, and reduced production cost.
On the degree of stability of measured hypnotizability over a 25-year period.

Conducted a longitudinal study of hypnotizability, as measured by the Stanford Hypnotic Susceptibility Scale, Form A, that yielded a relatively high degree of stability in hypnotic responsiveness over repeated testings spanning a 25-year period. The 50 Ss were retested in 1985, after tests when they were students, between 1958-1962 and again in 1970. The statistically significant stability coefficients were . 64 (10-year retest), . 82 (15-year retest), and . 71 (25-year retest). The means did not change significantly, and the median change in the scores of individuals was only 1 point on the 12-item scale. A set of score measures and their intercorrelations are insufficient to resolve the issue of why stability occurs. The stability of hypnotizability over time compares favorably with that of other measures of individual differences.
Mapping the navigational knowledge of individually foraging ants, Myrmecia croslandi

Ants are efficient navigators, guided by path integration and visual landmarks. Path integration is the primary strategy in landmark-poor habitats, but landmarks are readily used when available. The landmark panorama provides reliable information about heading direction, routes and specific location. Visual memories for guidance are often acquired along routes or near to significant places. Over what area can such locally acquired memories provide information for reaching a place? This question is unusually approachable in the solitary foraging Australian jack jumper ant, since individual foragers typically travel to one or two nest-specific foraging trees. We find that within 10 m from the nest, ants both with and without home vector information available from path integration return directly to the nest from all compass directions, after briefly scanning the panorama. By reconstructing panoramic views within the successful homing range, we show that in the open woodland habitat of these ants, snapshot memories acquired close to the nest provide sufficient navigational information to determine nest-directed heading direction over a surprisingly large area, including areas that animals may have not visited previously.
Recovery from spontaneous confabulations parallels recovery of temporal confusion in memory

Background: In previous studies, the authors found that patients with spontaneous confabulation differ from those with nonconfabulating amnesia by 1) temporal context confusion (TCC) in memory based on an inability to suppress intrusions of currently irrelevant memory traces into ongoing thinking; and 2) lesions involving the orbitofrontal cortex, basal forebrain, or amygdala and perirhinal cortex. Objectives: To study the long-term clinical course of spontaneous confabulations, determine whether TCC in memory also parallels the clinical course of spontaneous confabulations, and study the impact of lesion site on clinical course. Methods: Eight patients with spontaneous confabulation were re-examined 18 months after onset. Tests of memory and executive functioning and measurement of TCC in memory were again applied. MRI according to a standard protocol was performed to determine areas of permanent damage. Results: Seven patients eventually stopped confabulating. TCC, but not common memory or executive tests, precisely paralleled the course of spontaneous confabulations. Patients with isolated, less extensive, orbitofrontal lesions stopped confabulating first and had the best neuropsychological outcome. Patients with basal forebrain lesions continued to confabulate for several months and remained amnesic. One patient with extensive orbitofrontal damage and perirhinal cortex damage continues to confabulate after more than 3 years, continuing to confuse memory traces. Conclusions: Temporal context confusion in memory is not only the sole feature reliably separating patients with spontaneous confabulation from those with nonconfabulating amnesia in the acute stage, it is also the only feature that precisely parallels the clinical course of spontaneous confabulations. Most patients eventually stop confabulating but duration of confabulations depends on the lesion site.
Classification using intersection kernel support vector machines is efficient

Straightforward classification using kernelized SVMs requires evaluating the kernel for a test vector and each of the support vectors. For a class of kernels we show that one can do this much more efficiently. In particular we show that one can build histogram intersection kernel SVMs (IKSVMs) with runtime complexity of the classifier logarithmic in the number of support vectors as opposed to linear for the standard approach. We further show that by precomputing auxiliary tables we can construct an approximate classifier with constant runtime and space requirements, independent of the number of support vectors, with negligible loss in classification accuracy on various tasks. This approximation also applies to 1 - chi2 and other kernels of similar form. We also introduce novel features based on a multi-level histograms of oriented edge energy and present experiments on various detection datasets. On the INRIA pedestrian dataset an approximate IKSVM classifier based on these features has the current best performance, with a miss rate 13% lower at 10-6 False Positive Per Window than the linear SVM detector of Dalal & Triggs. On the Daimler Chrysler pedestrian dataset IKSVM gives comparable accuracy to the best results (based on quadratic SVM), while being 15times faster. In these experiments our approximate IKSVM is up to 2000times faster than a standard implementation and requires 200times less memory. Finally we show that a 50times speedup is possible using approximate IKSVM based on spatial pyramid features on the Caltech 101 dataset with negligible loss of accuracy.
Cryptosporidium parvum at Different Developmental Stages Modulates Host Cell Apoptosis In Vitro

ABSTRACT We studied apoptosis in a human ileocecal adenocarcinoma tumor cell line (HCT-8) infected with Cryptosporidium parvum, from 2 to 72 h postinfection (h.p.i.). At 2 h.p.i. , the percentage of annexin V-positive cells in the cell culture had increased to 10% compared to 2.5% in noninfected control culture; sorted infected cells expressed mRNA of FasL, the active form of caspase 3, and high caspase 3 activity, whereas the noninfected neighboring cells sorted from the same culture showed no signs of apoptosis. At 24 h.p.i. , the percentages of early (annexin V positive) and late (DNA fragment) apoptotic cells were 13 and 2%, respectively, in the entire cell culture, and these percentages were not statistically significant in comparison with those from noninfected control cultures. At this time, sorted infected cells expressed the inactive form of caspase 3, a low caspase 3 activity, and the antiapoptotic protein Bcl-2. Noninfected cells sorted from the same culture showed expression of the active form of caspase 3, a moderate caspase 3 activity, and no Bcl-2 expression. At 48 h.p.i. , the percentages of early and late apoptotic cells and caspase 3 activity had increased in the total cell culture, and both sorted infected and noninfected cells showed the active form of caspase 3. These results show that C. parvum, depending on its developmental stage, can inhibit (at the trophozoite stage) or promote (at the sporozoite and merozoite stages) host cell apoptosis, suggesting that it is able to interact with and regulate the host-cell gene expression.
Array Designs for Long-Distance Wireless Power Transmission: State-of-the-Art and Innovative Solutions

The concept of long-range wireless power transmission (WPT) has been formulated shortly after the invention of high power microwave amplifiers. The promise of WPT, energy transfer over large distances without the need to deploy a wired electrical network, led to the development of landmark successful experiments, and provided the incentive for further research to increase the performances, efficiency, and robustness of these technological solutions. In this framework, the key-role and challenges in designing transmitting and receiving antenna arrays able to guarantee high-efficiency power transfer and cost-effective deployment for the WPT system has been soon acknowledged. Nevertheless, owing to its intrinsic complexity, the design of WPT arrays is still an open research field whose importance is growing as the possibility to transfer energy by means of electromagnetic waves gathers more and more interest from the applicative viewpoint. This paper is aimed at reviewing the array design approaches proposed in the state of the art for long-range wireless power transmission, highlighting the latest advances and innovative solutions as well as envisaging possible future trends of the research in this area.
Enhanced Neural Cell Adhesion and Neurite Outgrowth on Graphene-Based Biomimetic Substrates

Neural cell adhesion and neurite outgrowth were examined on graphene-based biomimetic substrates. The biocompatibility of carbon nanomaterials such as graphene and carbon nanotubes (CNTs), that is, single-walled and multiwalled CNTs, against pheochromocytoma-derived PC-12 neural cells was also evaluated by quantifying metabolic activity (with WST-8 assay), intracellular oxidative stress (with ROS assay), and membrane integrity (with LDH assay). Graphene films were grown by using chemical vapor deposition and were then coated onto glass coverslips by using the scooping method. Graphene sheets were patterned on SiO2/Si substrates by using photolithography and were then covered with serum for a neural cell culture. Both types of CNTs induced significant dose-dependent decreases in the viability of PC-12 cells, whereas graphene exerted adverse effects on the neural cells just at over 62.5 ppm. This result implies that graphene and CNTs, even though they were the same carbon-based nanomaterials, show differential influences on neural cells. Furthermore, graphene-coated or graphene-patterned substrates were shown to substantially enhance the adhesion and neurite outgrowth of PC-12 cells. These results suggest that graphene-based substrates as biomimetic cues have good biocompatibility as well as a unique surface property that can enhance the neural cells, which would open up enormous opportunities in neural regeneration and nanomedicine.