Miracle-dz/UniFAR-FTUs huggingface dataset:
Petrology of phlogopite‐sapphirine‐bearing Al‐Mg granulites from Ihouhaouene, In Ouzzal, Hoggar, Algeria: an example of phlogopite stability at high temperature

Al-Mg granulites, with cordierite, garnet, sapphirine, orthopyroxene, sillimanite, spinel, phlogopite, K-feldspar, plagioclase and variable quartz from Ihouhaouene (In Ouzzal, Algeria), display a range of decompression textures involving the breakdown of orthopyroxene and sillimanite, and of garnet. The succession of parageneses suggests that the P–T–t evolution corresponds to decompression with cooling from peak conditions of about 950°C and 10 kbar. This decompression path is obtained from the paragenetic analysis in the FMAS system. However, according to current KFMASH grids, this P–T–t evolution should take place outside the stability field of phlogopite+quartz; yet this assemblage is probably stable during most of the P-T evolution, notably during peak metamorphism. This discrepancy is interpreted as the effect of the high content of F in phlogopite which should shift its stability limit towards higher temperature. The consequences of this shift on the phase relationships in the KFeMASH system are investigated and it is concluded that a topological inversion could exist in the F-bearing system.
CD44 is a determinant of inflammatory bone loss

Chronic inflammation is a major trigger of local and systemic bone loss. Disintegration of cell–matrix interaction is a prerequisite for the invasion of inflammatory tissue into bone. CD44 is a type I transmembrane glycoprotein that connects a variety of extracellular matrix proteins to the cell surface. Tumor necrosis factor (TNF) is a major inducer of chronic inflammation and its overexpression leads to chronic inflammatory arthritis. By generating CD44−/− human TNF-transgenic (hTNFtg) mice, we show that destruction of joints and progressive crippling is far more severe in hTNFtg mice lacking CD44, which also develop severe generalized osteopenia. Mutant mice exhibit an increased bone resorption due to enhanced number, size, and resorptive capacity of osteoclasts, whereas bone formation and osteoblast differentiation are not affected. Responsiveness of CD44-deficient osteoclasts toward TNF is enhanced and associated with increased activation of the p38 mitogen-activated protein kinase. These data identify CD44 as a critical inhibitor of TNF-driven joint destruction and inflammatory bone loss.
The autoregulation of a eukaryotic DNA transposon

How do DNA transposons live in harmony with their hosts? Bacteria provide the only documented mechanisms for autoregulation, but these are incompatible with eukaryotic cell biology. Here we show that autoregulation of Hsmar1 operates during assembly of the transpososome and arises from the multimeric state of the transposase, mediated by a competition for binding sites. We explore the dynamics of a genomic invasion using a computer model, supported by in vitro and in vivo experiments, and show that amplification accelerates at first but then achieves a constant rate. The rate is proportional to the genome size and inversely proportional to transposase expression and its affinity for the transposon ends. Mariner transposons may therefore resist post-transcriptional silencing. Because regulation is an emergent property of the reaction it is resistant to selfish exploitation. The behavior of distantly related eukaryotic transposons is consistent with the same mechanism, which may therefore be widely applicable. DOI: http://dx.doi. org/10.7554/eLife.00668. 001
Twenty-First-Century Projections of Snowfall and Winter Severity across Central-Eastern North America*,+

AbstractStatistically downscaled climate projections from nine global climate models (GCMs) are used to force a snow accumulation and ablation model (SNOW-17) across the central-eastern North American Landscape Conservation Cooperatives (LCCs) to develop high-resolution projections of snowfall, snow depth, and winter severity index (WSI) by the middle and late twenty-first century. Here, projections of a cumulative WSI (CWSI) known to influence autumn–winter waterfowl migration are used to demonstrate the utility of SNOW-17 results. The application of statistically downscaled climate data and a snow model leads to a better representation of lake processes in the Great Lakes basin, topographic effects in the Appalachian Mountains, and spatial patterns of climatological snowfall, compared to the original GCMs. Annual mean snowfall is simulated to decline across the region, particularly in early winter (December–January), leading to a delay in the mean onset of the snow season. Because of a warming-induced a.
Identification of a cytogenetic deletion and of four novel mutations (Q69X, I172F, G188V, G197R) affecting the gene for ornithine transcarbamylase (OTC) in Spanish patients with OTC deficiency

A deletion of at least 11.5 cM in the paternal X chromosome mapping between microsatellites DXS989 and DXS1003 and encompassing the genes for ornithine transcarbamylase (OTC), retinitis pigmentosa GTPase regulator (RPGR) and dystrophin, was associated with the loss of band Xp21 in a female patient with OTC deficiency. Another four female patients were heterozygous for point mutations in the OTC gene: the nonsense mutation Q69X or the missense mutations I172F, G188V and G197R. In the OTC amino acid sequence, I172 and G197 are proximate to residues involved in catalysis, and G188 is within a loop joining helix 5 and strand 6 in the core of the ornithine‐bindingdomain. Therefore, the mutations of these residues may cause structural changes affecting catalysis and/or the architecture of the ornithine domain. The mutation appeared “de novo” in the patients or, in one case, in the mother of the patient, in agreement with the predominance of “de novo” mutations in female patients of OTC deficiency. There was full agreement between the results of mutational analysis and of allopurinol testing in the patients and their female relatives, supporting the value of the allopurinol test in the detection of carriers of OTC deficiency. This deficiency is a genetically heterogeneous X‐linked condition. Hum Mutat 14:352–353, 1999. © 1999 Wiley‐Liss, Inc.
Further definition of the subthalamic target for arrest of tremor.

✓ During stereotaxic procedures for the treatment of tremor, the simple introduction of a 1-mm diameter electrode in the subthalamus may arrest the tremor on the contralateral side. Placement of the electrodes in relation to the ventricular system and intercommissural (AC-PC) line was studied radiologically in 88 cases operated on. The proximity of the medial lemniscus and pyramidal fibers was assessed by means of electrical monopolar stimulation. A proportional reduction of the AC-PC line was made in all cases by dividing it in 10 equal parts. The resultant 10ths were squared to divide the areas above and below the line. The place where the tremor was arrested corresponded to a small area that extended just in front of the area of sensory responses and medial to the area of motor responses. It seemed to have a topographical organization, as the tremor could be selectively arrested in the arm or the leg. Analysis of results on anatomical grounds showed the area in question corresponded to the prelemniscal.
Nitric oxide synthase inhibition in humans reduces cerebral blood flow but not the hyperemic response to hypercapnia.

BACKGROUND AND PURPOSE Animal studies suggest that nitric oxide (NO) is important in basal cerebral blood flow (CBF) regulation and that it may mediate the vasodilatory response to carbon dioxide. We investigated its role in the human circulation using the NO synthase inhibitor N(G)-monomethyl-L-arginine (L-NMMA). METHODS L-NMMA was administered as an intravenous bolus at three doses (1, 3, and 10 mg/kg). CBF was assessed by color velocity ultrasonic imaging of internal and common carotid artery volume flow (ICA flow and CCA flow) and transcranial Doppler ultrasound measurement of middle cerebral artery flow velocity (MCAv). The pressor effect of L-NMMA was controlled for by comparison with noradrenaline titrated to effect an equivalent blood pressure elevation. RESULTS L-NMMA produced a dose-dependent reduction in basal mean+/-SD CCA flow from 415.2+/-51.9 to 294+/-56.2 mL/min (at 10 mg/kg) and ICA flow from 268.8+/-59.4 to 226.2+/-72.6 mL/min (P<.005 and P<.05, respectively, comparing areas under the dose-response curve). This was reversed by L-arginine. Mean+/-SD systemic blood pressure rose from 85.2+/-6.4 to 100.8+/-9.6 mm Hg (P<.01). There was no significant reduction in MCAv. There was no significant change in the CBF response to either 6% or 8% carbon dioxide after L-NMMA. Noradrenaline produced a lesser fall in basal CCA flow (12.0%) but had a similar effect on the hypercapnic response. CONCLUSIONS Basal NO release is important in controlling human CBF, but intravenously administered L-NMMA does not inhibit the hypercapnic hyperemic response in humans. The discrepancy between CBF and MCAv after L-NMMA administration is consistent with MCA vasoconstriction. Neuronal NO synthase inhibition may be protective in stroke. However, our results suggest that nonselective NO synthase inhibitors such as L-NMMA should be used with caution because they reduce CBF.
The Value of Historical Data in Flood Frequency Analysis

A common problem in flood frequency analysis is estimation, from a short gauged record, of the flood corresponding to a return period of 50–1000 years. One would expect that an estimate of the historical maximum event; i.e., the maximum flood in a period of perhaps 100–200 years, would, if properly included in the estimation procedure, improve the resulting estimate of the flood magnitude at the given return period. We attempt to assess the value of historical information using computer simulation. An annual flood sequence and a historical maximum event are generated from ah extreme-value distribution (of type I or II) and quantitiles of the distribution are estimated by maximum likelihood, both including the excluding the historical event. After many such simulations have been performed the accuracy of the quantile estimates is assessed. We also consider the effect of errors in the magnitude of historical discharge estimates and the use of historical data in regional flood frequency analysis.
Adsorption of bile salts by soya-bean flour, wheat bran, lucerne (Medicago sativa), sawdust and lignin; the effect of saponins and other plant constituents

1. The adsorption of bile salts from aqueous solution on to soya-bean flour, wheat bran, fine dry sawdust and lucerne (Medicago sativa) wasmeasured. Adsorption on to the residuum after the first three of these substances had been extracted with organic solvents, pronase or solvents, pronase and acid (to produce lignin) was also measured. 2. The removal of saponins from soya-bean flour did not affect bile salt adsorption, and bile salts were adsorbed on to lignin and on to wheat bran (deficient in saponins). Although our methods differed from Oakenfull & Fenwick (1978) we were unable to substantiate their conclusions that saponins are responsible for most bile salt binding to fibrous substances in vitro.
Intuitive Biases in Choice versus Estimation: Implications for the Wisdom of Crowds

Although researchers have documented many instances of crowd wisdom, it is important to know whether some kinds of judgments may lead the crowd astray, whether crowds' judgments improve with feedback over time, and whether crowds' judgments can be improved by changing the way judgments are elicited. We investigated these questions in a sports gambling context (predictions against point spreads) believed to elicit crowd wisdom. In a season-long experiment, fans wagered over $20,000 on NFL football predictions. Contrary to the wisdom-of-crowds hypothesis, faulty intuitions led the crowd to predict "favorites" more than "underdogs" against point spreads that disadvantaged favorites, even when bettors knew that the spreads disadvantaged favorites. Moreover, the bias increased over time, a result consistent with attributions for success and failure that rewarded intuitive choosing. However, when the crowd predicted game outcomes by estimating point differentials rather than by predicting against point spreads, its predictions were unbiased and wiser.
An In-body communication link based on 400 MHz MICS band wireless body area networks

Implant wireless body area networks (WBANs) are becoming increasingly significant for numerous applications in the healthcare and medical sectors. Here an in-body communication model is proposed, based on a 1 mm resolution mesh kneeling position inhomogeneous 30-year male body model in the 400 MHz medical implant communication service (MICS) band. Firstly, semi-empirical path loss models for numerous homogeneous tissues and a heterogeneous human body model are proposed. Then we investigate the bit error rate (BER) performance using the heterogeneous human body channel model. Coupled with link margin analysis, this model can be applied to future implementations and system design research work.
Modeling Salt Marsh Cover Response to Relative Water Level: Local Fault Motion vs. Global Eustatic Rise

ABSTRACT Cline, M.D.; Feagin, R.A. , and Yeager, K.M. , 2014. Modeling salt marsh cover response to relative water level: Local fault motion versus global eustatic rise. The movement of growth faults on subsiding coastlines contributes to wetland losses, yet it has been unclear whether they can provide a point of reference for understanding the impacts of climate-induced relative sea level rise (RSLR) on wetland habitat. The objective of this study was to simulate land cover conversion as a function of RSLR within a wetland and to compare and contrast fault-induced elevation change with Intergovernmental Panel on Climate Change (IPCC) 2007 sea level rise projections. For an area surrounding a growth fault in Matagorda, Texas, aerial images were draped over a digital elevation model (DEM) to identify the dependent elevations of land cover classes and, subsequently, to model potential future outcomes based on variable RSLR rates. Modeling results show that rapid water-level rise can force wetland land-cover class conversion regardless of whether the rise is caused by vertical fault displacement or eustatic sea level rise. The model findings point to an RSLR rate of approximately 0.36 cm/y for complete loss of the Matagorda wetlands by 2100, although the sustainability of the wetlands in their current configuration and coverage will likely require rates well below the IPCC 2007 low rise rate. Current and historical record conditions of sea level rise, along the Texas Gulf Coast, greatly exceed the rates discussed, leaving a grim outlook for the coast in this region.
Performance Evaluation of a Dataflow Architecture

The formulation and validation of an analytical approach for the performance evaluation of the Manchester dataflow computer is discussed. The analytical approach is based on closed queuing network models. The average parallelism of the dataflow graph being executed on the dataflow architecture is shown to be related to the population of the closed network. The model of the dataflow computer is validated by comparing the analytical results to those obtained from the prototype Manchester dataflow computer and from simulation. The bottleneck centers in the prototype machine have been identified through the model, and various architectural modifications have been investigated from performance considerations. >
EMDR Effects on Pursuit Eye Movements

This study aimed to objectivize the quality of smooth pursuit eye movements in a standard laboratory task before and after an Eye Movement Desensitization and Reprocessing (EMDR) session run on seven healthy volunteers. EMDR was applied on autobiographic worries causing moderate distress. The EMDR session was complete in 5 out of the 7 cases; distress measured by SUDS (Subjective Units of Discomfort Scale) decreased to a near zero value. Smooth pursuit eye movements were recorded by an Eyelink II video system before and after EMDR. For the five complete sessions, pursuit eye movement improved after their EMDR session. Notably, the number of saccade intrusions—catch-up saccades (CUS)—decreased and, reciprocally, there was an increase in the smooth components of the pursuit. Such an increase in the smoothness of the pursuit presumably reflects an improvement in the use of visual attention needed to follow the target accurately. Perhaps EMDR reduces distress thereby activating a cholinergic effect known to improve ocular pursuit.
The Role of Self-Construal on Preferred Communication Styles with Humanoid Robots

Research on human–human communication has identified that people apply different constraints in communication with each other. Application of such constraints as social concerns over feeling, imposition, and disapproval and task concerns over clarity and effectiveness has also been found to be influenced by people's self-construal, being independent or interdependent. Do these constraints and individual difference in self-construal matter in communication with humanoid robots? This study uses the theoretical framework of communication constraints to compare whether or not people of different self-construals apply social-oriented and task-oriented constraints differently to humanoid social robot targets. A total of 161 students from the University of Hawaii at Manoa participated in the study. The participants completed a questionnaire that determined their concern for the five communication constraints (feelings, nonimposition, disapproval, clarity, and effectiveness) in situations involving robots, as well as scales measuring self-construal. The results show interdependent self-construal related significantly with the concerns over avoiding hurting the humanoid's feelings, avoiding inconveniencing the humanoid robot, and avoiding being disliked by the humanoid robot. On the other hand, independent self-construal related significantly with the concern over clarity in communicating with the humanoid robot. However, self-construal did not influence one's concern of effectiveness (a task-oriented constraint) in interaction with humanoid robots. The results of the research offer new insight into the linkage between self-construal, a cultural concept at the individual level, and how human–robot communication is psychologically structured and constrained.
AoD-adaptive subspace codebook for channel feedback in FDD massive MIMO systems

Channel feedback is essential for frequency division duplex (FDD) massive multiple-input multiple-output (MIMO) systems to realize precoding and power allocation. Traditional codebooks for channel feedback, where the required number of feedback bits is proportional to the number of base station (BS) antennas, can not scale up with massive MIMO due to the large number of BS antennas. To solve this problem, in this paper, we propose an angle-of-departure (AoD) adaptive subspace codebook to reduce the codebook size and feedback overhead. Specifically, by leveraging the concept of angle coherence time, which implies that the path AoDs vary much slower than path gains, we propose an AoD-adaptive subspace codebook to quantize the channel vector in a more accurate way. We also provide performance analysis of the proposed AoD-adaptive subspace codebook, where we prove that the required number of feedback bits only scales linearly with the number of resolvable AoDs, which is much smaller than the number of BS antennas. This quantitative result is also verified by simulations.
Enhancing Collaborative Filtering by User Interest Expansion via Personalized Ranking

Recommender systems suggest a few items from many possible choices to the users by understanding their past behaviors. In these systems, the user behaviors are influenced by the hidden interests of the users. Learning to leverage the information about user interests is often critical for making better recommendations. However, existing collaborative-filtering-based recommender systems are usually focused on exploiting the information about the user's interaction with the systems; the information about latent user interests is largely underexplored. To that end, inspired by the topic models, in this paper, we propose a novel collaborative-filtering-based recommender system by user interest expansion via personalized ranking, named iExpand. The goal is to build an item-oriented model-based collaborative-filtering framework. The iExpand method introduces a three-layer, user-interests-item, representation scheme, which leads to more accurate ranking recommendation results with less computation cost and helps the understanding of the interactions among users, items, and user interests. Moreover, iExpand strategically deals with many issues that exist in traditional collaborative-filtering approaches, such as the overspecialization problem and the cold-start problem. Finally, we evaluate iExpand on three benchmark data sets, and experimental results show that iExpand can lead to better ranking performance than state-of-the-art methods with a significant margin.
A Novel Approach Based on PCNNs Template for Fingerprint Image Thinning

A PCNNs-based square-and-triangle-template method for binary fingerprint image thinning is proposed. The algorithm is iterative: combined sequential and parallel processing is employed to accelerate execution. When a neuron satisfies the square template, the pixel corresponding to this neuron will be noted during the process and be deleted until the end of the iteration; on the other hand, if a neuron meets a triangle template, it will be removed directly. In addition, this proposed algorithm can be effective for fingerprint thinning without considering the direction. The results showed that, with combined sequential and parallel conditions for border pixels removal, the algorithm could not only speed up the fingerprint thinning process, but also be applied to other common images. Furthermore, this algorithm might be applied to fingerprint identification systems to save time for identifying and eliminating spurious minutiae.
Cu/Zn superoxide dismutase mutants associated with amyotrophic lateral sclerosis show enhanced formation of aggregates in vitro

Mutations in Cu/Zn superoxide dismutase (SOD) are associated with the fatal neurodegenerative disorder amyotrophic lateral sclerosis (ALS). There is considerable evidence that mutant SOD has a gain of toxic function; however, the mechanism of this toxicity is not known. We report here that purified SOD forms aggregates in vitro under destabilizing solution conditions by a process involving a transition from small amorphous species to fibrils. The assembly process and the tinctorial and structural properties of the in vitro aggregates resemble those for aggregates observed in vivo. Furthermore, the familial ALS SOD mutations A4V, G93A, G93R, and E100G decrease protein stability, which correlates with an increase in the propensity of the mutants to form aggregates. These mutations also increase the rate of protein unfolding. Our results suggest three possible mechanisms for the increase in aggregation: (i) an increase in the equilibrium population of unfolded or of partially unfolded states, (ii) an increase in the rate of unfolding, and (iii) a decrease in the rate of folding. Our data support the hypothesis that the gain of toxic function for many different familial ALS-associated mutant SODs is a consequence of protein destabilization, which leads to an increase in the formation of cytotoxic protein aggregates.