Miracle-dz/UniFAR-FTUs huggingface dataset:
Food fight: sexual conflict over free amino acids in the nuptial gifts of male decorated crickets

In decorated crickets, Gryllodes sigillatus, the spermatophore that a male transfers at mating includes a gelatinous spermatophylax that the female consumes, delaying her removal of the sperm‐filled ampulla. Male fertilization success increases with the length of time females spend feeding on the spermatophylax, while females may benefit by prematurely discarding the spermatophylaxes of undesirable males. This sexual conflict should favour males that produce increasingly appealing spermatophylaxes, and females that resist this manipulation. To determine the genetic basis of female spermatophylax feeding behaviour, we fed spermatophylaxes to females of nine inbred lines and found that female genotype had a major influence on spermatophylax feeding duration. The amino acid composition of the spermatophylax was also significantly heritable. There was a positive genetic correlation between spermatophylax feeding duration and the gustatory appeal of the spermatophylax. This correlation suggests that genes expressed in males that produce more manipulative spermatophylaxes are positively linked to genes expressed in females that make them more vulnerable to manipulation. Outbred females spent less time feeding on spermatophylaxes than inbred females, and thus showed greater resistance to male manipulation. Further, in a nonspermatophylax producing cricket (Acheta domesticus), females were significantly more prone to feeding on spermatophylaxes than outbred female Gryllodes. Collectively, these results suggest a history of sexually antagonistic coevolution over the consumption of nuptial food gifts.
Localization and Characterization of the Carbon Tetrachloride Transformation Activity of Pseudomonas sp. Strain KC

Previous research has established that Pseudomonas sp. strain KC rapidly transforms carbon tetrachloride (CT) to carbon dioxide (45 to 55%), a nonvolatile fraction (45 to 55%), and a cell-associated fraction ((equiv)5%) under denitrifying, iron-limited conditions. The present study provides additional characterization of the nonvolatile fraction, demonstrates that electron transfer plays a role in the transformation, and establishes the importance of both extracellular and intracellular factors. Experiments with (sup14)C-labeled CT indicate that more than one nonvolatile product is produced during CT transformation by strain KC. One of these products, accounting for about 20% of the [(sup14)C]CT transformed, was identified as formate on the basis of its elution time from an ion-exchange column, its boiling point, and its conversion to (sup14)CO(inf2) when incubated with formate dehydrogenase. Production of formate requires transfer of two electrons to the CT molecule. The role of electron transfer was also supported by experiments demonstrating that stationary-phase cells that do not transform CT can be stimulated to transform CT when supplemented with acetate (electron donor), nitrate (electron acceptor), or a protonophore (carbonyl cyanide m-chlorophenylhydrazone). The location of transformation activity was also evaluated. By themselves, washed cells did not transform CT to a significant degree. Occasionally, CT transformation was observed by cell-free culture supernatant, but this activity was not reliable. Rapid and reliable CT transformation was only obtained when washed whole cells were reconstituted with culture supernatant, indicating that both extracellular and intracellular factors are normally required for CT transformation. Fractionation of culture supernatant by ultrafiltration established that the extracellular factor or factors are small, with an apparent molecular mass of less than 500 Da. The extracellular factor or factors were stable after lyophilization to powder and were extractable with acetone. Addition of micromolar levels of iron inhibited CT transformation in whole cultures, but the level of iron needed to inhibit CT transformation was over 100-fold higher for washed cells reconstituted with a 10,000-Da supernatant filtrate. Thus, the inhibitory effects of iron are exacerbated by a supernatant factor or factors with a molecular mass greater than 10,000 Da.
Evaluation of Strategies to Reducing Traction Energy Consumption of Metro Systems Using an Optimal Train Control Simulation Model

Increasing attention is being paid to the energy efficiency in metro systems to reduce the operational cost and to advocate the sustainability of railway systems. Classical research has studied the energy-efficient operational strategy and the energy-efficient system design separately to reduce the traction energy consumption. This paper aims to combine the operational strategies and the system design by analyzing how the infrastructure and vehicle parameters of metro systems influence the operational traction energy consumption. Firstly, a solution approach to the optimal train control model is introduced, which is used to design the Optimal Train Control Simulator(OTCS). Then, based on the OTCS, the performance of some important energy-efficient system design strategies is investigated to reduce the trains’ traction energy consumption, including reduction of the train mass, improvement of the kinematic resistance, the design of the energy-saving gradient, increasing the maximum traction and braking forces, introducing regenerative braking and timetable optimization. As for these energy-efficient strategies, the performances are finally evaluated using the OTCS with the practical operational data of the Beijing Yizhuang metro line. The proposed approach gives an example to quantitatively analyze the energy reduction of different strategies in the system design procedure, which may help the decision makers to have an overview of the energy-efficient performances and then to make decisions by balancing the costs and the benefits.
Ribavirin potentiates interferon action by augmenting interferon‐stimulated gene induction in hepatitis C virus cell culture models

The combination of pegylated interferon (PEG‐IFN) and ribavirin is the standard treatment for chronic hepatitis C. Our recent clinical study suggests that ribavirin augments the induction of interferon‐stimulated genes (ISGs) in patients treated for hepatitis C virus (HCV) infection. In order to further characterize the mechanisms of action of ribavirin, we examined the effect of ribavirin treatment on ISG induction in cell culture. In addition, the effect of ribavirin on infectious HCV cell culture systems was studied. Similar to interferon (IFN)‐α, ribavirin potently inhibits JFH‐1 infection of Huh7.5. 1 cells in a dose‐dependent manner, which spans the physiological concentration of ribavirin in vivo. Microarray analysis and subsequent quantitative polymerase chain reaction assays demonstrated that ribavirin treatment resulted in the induction of a distinct set of ISGs. These ISGs, including IFN regulatory factors 7 and 9, are known to play an important role in anti‐HCV responses. When ribavirin is used in conjunction with IFN‐α, induction of specific ISGs is synergistic when compared with either drug applied separately. Direct up‐regulation of these antiviral genes by ribavirin is mediated by a novel mechanism different from those associated with IFN signaling and intracellular double‐stranded RNA sensing pathways such as RIG‐I and MDA5. RNA interference studies excluded the activation of the Toll‐like receptor and nuclear factor κB pathways in the action of ribavirin. Conclusion: Our study suggests that ribavirin, acting by way of a novel innate mechanism, potentiates the anti‐HCV effect of IFN. Understanding the mechanism of action of ribavirin would be valuable in identifying novel antivirals (HEPATOLOGY 2011.)
Trauma outcomes in the rural developing world: comparison with an urban level I trauma center.

Trauma is well known as a major cause of death and disability in the developed world, but has been inadequately studied in developing nations. We reviewed 539 trauma patients admitted from 1987 through 1991 to a rural African hospital, the Holy Family Hospital (HFH) in Berekum, Ghana, and compared these results with 14,270 patients admitted during the same period to a level I trauma center, the Harborview Medical Center (HMC) in Seattle, Washington. At HFH, 59% of patients were seen > 24 hours after injury, compared with 4% of HMC patients (p < 0.001). Only 25% of HFH patients received prehospital care, compared with 82% of HMC patients (p < 0.001). Mean ISS was higher at HMC (10.0 +/- 6.3) than a HFH (6.7 +/- 6.5) (p < 0.001), but trauma mortality rates were identical (6%) at both institutions. Neurologic injuries were the leading cause of death at both HFH (62%) and HMC (54%). There was no significant difference between institutions in mortality for patients with ISS 1-8 (HMC: 0.7% n = 6390; HFH: 0.3%, n = 342). There was a marked decrease in mortality for patients with ISS 9-24 at HMC (3%, n = 3709) compared with HFH (10%, n = 146) (p < 0.001). There was a less pronounced decrease in mortality for patients with ISS > 24 at HMC (41%, n = 1520) compared with HFH (73%, n = 26) (p < 0.01). The type and the severity of injuries causing fatalities in this developing nation suggest that no inexpensive hospital-based changes would improve outcomes. (ABSTRACT TRUNCATED AT 250 WORDS)
The patient-specific functional scale: validation of its use in persons with neck dysfunction.

Self-report measures of disability are being used more frequently to assess patients' outcomes in clinical practice. This study examines the reliability, validity, and sensitivity to change of the Patient-Specific Functional Scale when applied to persons with neck dysfunction. The Patient-Specific Functional Scale and Neck Disability Index were applied at the initial visit, within 72 hours of the initial visit, and following 1-4 weeks of treatment in 31 patients with cervical dysfunction. At the time of the initial visit, the clinician made an estimate of patients' prognoses on a five-point scale. This estimate served as an priori construct for change: patients with better ratings would change more. The results demonstrate excellent reliability (R = .92) validity (r = .73-.83 compared with the Neck Disability Index, and r = .52-.64 compared with the prognosis rating), and sensitivity of change (r = .79-.83 compared with Neck Disability Index change scores, and r = .46-.53 compared with the prognosis rating). No difference was found between the Patient-Specific Functional Scale and Neck Disability Index in their ability to detect change over time. The results of this study are consistent with previous investigations which have concluded that the Patient-Specific Functional Scale is an efficient and valid measure for assessing disability and change in disability in persons with low back pain and knee dysfunction.
What is “theory of mind”? Concepts, cognitive processes and individual differences

Research on “theory of mind” has traditionally focused on a narrow participant group (preschool children) using a narrow range of experimental tasks (most notably, false-belief tasks). Recent work has greatly expanded the age range of human participants tested to include human infants, older children, and adults, has devised new tasks, and has adopted methods from cognitive psychology and neuroscience. However, theoretical work has not kept pace with these changes, with the result that studies using one kind of method or participant group often inherit assumptions about the nature of theory of mind from other research, with little regard for whether these assumptions are appropriate. I argue that three distinct approaches to thinking about theory of mind are already implicit in research practice, and that future work, whether with infants, children, or adults, will benefit from articulating these approaches more clearly and following their different implications for what theory of mind is and how it should be studied.
An online POMDP algorithm for complex multiagent environments

In this paper, we present an online method for POMDPs, called RTBSS (Real-Time Belief Space Search), which is based on a look-ahead search to find the best action to execute at each cycle in an environment. We thus avoid the overwhelming complexity of computing a policy for each possible situation. By doing so, we show that this method is particularly efficient for large real-time environments where offline approaches are not applicable because of their complexity. We first describe the formalism of our online method, followed by some results on standard POMDPs. Then, we present an adaptation of our method for a complex multiagent environment and results showing its efficiency in such environments.
MUC1 and MUC2 expression in salivary gland tumors and in non‐neoplastic salivary gland tissue

The expression of MUC1 and MUC2 was studied in salivary gland tumors and non‐neoplastic salivary gland tissue. Formalin‐fixed paraffin‐embedded specimens from 101 patients (21 pleomorphic adenomas (PA), 22 Warthin's tumors (WT), 26 adenoid cystic carcinomas (ACC), 13 acinic cell adenocarcinomas (ACA), 9 mucoepidermoid carcinomas (MC), and 10 specimens of non‐neoplastic parotid and submandibular gland tissue) were immunostained. All salivary gland tumors expressed MUC1. A strong immunoreactivity was noted in WT and MC, a moderate in ACC and ACA, and a weak in PA. Strong expression of MUC2 was noted in all WT, moderate expression in MC, and weak expression in PA and ACA. All cases of ACC except for two were negative for MUC2. In general, MUC1 expression was stronger than that of MUC2. Non‐neoplastic salivary gland tissue revealed a moderate MUC1 and MUC2 expression in excretory ducts and a strong expression in striated ducts. The apical plasma membrane of some serous acini expressed MUC1. Mucous acini were negative for both antigens. No change in immunoreactivity was noted in cases of chronic sclerosing sialadenitis. In conclusion, the different expression pattern of MUC1 and MUC2 in salivary gland neoplasia may be of additional value for the classification of salivary gland tumors.
Ziprasidone and the activity of cytochrome P450 2D6 in healthy extensive metabolizers.

AIMS To determine whether ziprasidone alters the metabolizing activity of the 2D6 isoenzyme of cytochrome P450 (CYP2D6). METHODS Twenty-four healthy young subjects aged 18-45 years were screened for CYP2D6 metabolizing activity and shown to be extensive metabolizers of dextromethorphan. These subjects were then randomized to receive a single dose of ziprasidone 80 mg, paroxetine 20 mg or placebo, 2 h before receiving a dose of dextromethorphan. Urine samples for the determination of dextromethorphan concentrations were collected over the 8 h period following dextromethorphan dosing, and used for the determination of dextromethorphan/dextrorphan ratios. Blood samples were collected immediately before and up to 10 h after the administration of ziprasidone or paroxetine, and used to derive pharmacokinetic parameters of ziprasidone and paroxetine. RESULTS There were no statistically significant changes in the urinary dextromethorphan/dextrorphan ratio in the ziprasidone group or the placebo group. By contrast, there was a 10-fold increase in the urinary dextromethorphan/dextrorphan ratio in the paroxetine group and this differed significantly from those in the ziprasidone and placebo groups (P = 0.0001). CONCLUSIONS The findings of this study suggest that ziprasidone does not inhibit the clearance of drugs metabolized by CYP2D6.
Analyzing objects in images for estimating the delamination influence on load carrying capacity of composite laminates

The use of fiber reinforced plastics has increased in the last decades due to their unique properties. Advantages of their use are related with low weight, high strength and stiffness. Drilling of composite plates can be carried out in conventional machinery with some adaptations. However, the presence of typical defects like delamination can affect mechanical properties of produced parts. In this paper delamination influence in bearing stress of drilled hybrid carbon+glass/epoxy quasi-isotropic plates is studied by using image processing and analysis techniques. Results from bearing test show that damage minimization is an important mean to improve mechanical properties of the joint area of the plate. The appropriateness of the image processing and analysis techniques used in the measurement of the damaged area is demonstrated.
Aspects of Literary Response: A New Questionnaire

A newly developed instrument, the Literary Response Questionnaire (LRQ), provides scales that measure seven different aspects of readers’ orientation toward literary texts: Insight, Empathy, Imagery Vividness, Leisure Escape, Concern with Author, Story-Driven Reading, and Rejection of Literary Values. The present report presents evidence that each of these scales possesses satisfactory internal consistency, retest reliability, and factorial validity. Also, a series of five studies provided preliminary evidence that each scale may be located in a theoretically plausible network of relations with certain global personality traits (e.g., Absorption), with aspects of cognitive style (e.g., Regression in the Service of the Ego), and with some of the learning skills that are relevant to effective work in the classroom (e.g., Elaborative Processing). In a variety of teaching and research settings, the LRQ may be a useful measure of individual differences in readers’ orientation toward literary texts.
LEVELS OF EVIDENCE

Level 1 Evidence Level 1 evidence can come in one of 2 forms: a randomized clinical trial, which is associated with low study errors (low P value, confidence interval which excludes 1, or a ‘‘negative’’ result associated with a power of over 80%), or a meta-analysis. A meta-analysis refers to a study that statistically synthesizes the results of numerous ‘‘underpowered’’ randomized clinical trials and increases the confidence in an overall summary result. Unfortunately, limitations of meta-analyses include heterogeneity and publication bias. The Optic Neuritis Treatment Trial is an example of a randomized clinical trial which contains level 1 evidence.
Regulation of the severity of neuroinflammation and demyelination by TLR-ASK1-p38 pathway

Apoptosis signal‐regulating kinase 1 (ASK1) is an evolutionarily conserved mitogen‐activated protein kinase (MAPK) kinase kinase which plays important roles in stress and immune responses. Here, we show that ASK1 deficiency attenuates neuroinflammation in experimental autoimmune encephalomyelitis (EAE), without affecting the proliferation capability of T cells. Moreover, we found that EAE upregulates expression of Toll‐like receptors (TLRs) in activated astrocytes and microglia, and that TLRs can synergize with ASK1‐p38 MAPK signalling in the release of key chemokines from astrocytes. Consequently, oral treatment with a specific small molecular weight inhibitor of ASK1 suppressed EAE‐induced autoimmune inflammation in both spinal cords and optic nerves. These results suggest that the TLR‐ASK1‐p38 pathway in glial cells may serve as a valid therapeutic target for autoimmune demyelinating disorders including multiple sclerosis.
ER81 and CaMKIV identify anatomically and phenotypically defined subsets of mouse olfactory bulb interneurons

The mechanisms underlying dopamine (DA) phenotypic differentiation in the olfactory bulb (OB) have not yet been fully elucidated and are the subject of some controversy. OB DA interneurons destined for the glomerular layer were shown to originate in the subventricular zone (SVZ) and in the rostral migratory stream (RMS). The current study investigated whether calcium/calmodulin‐dependent protein kinase IV (CaMKIV) either alone or together with the Ets transcription factor ER81 was necessary for phenotypic determination during migration of progenitors. In most brain areas, including the OB, CaMKIV and ER81 displayed a reciprocal distribution. In the SVZ, only ER81 could be demonstrated. In the RMS, a subpopulation of progenitors contained ER81, but few, if any, contained CaMKIV. In OB, CaMKIV expression, restricted to deep granule cells, showed limited overlap with ER81. ER81 expression was weak in deep granule cells. Strong labeling occurred in the mitral and glomerular layers, where ER81 colabeled dopaminergic periglomerular cells that expressed either tyrosine hydroxylase (TH) or green fluorescent protein, the latter reporter gene under control of 9‐kb of 5′ TH promoter. Odor deprivation resulted in a significant 5.2‐fold decline in TH immunoreactivity, but ER81 exhibited a relatively small 1.7‐fold decline in immunoreactivity. TH expression as well as brain and bulb size were unchanged in CaMKIV knockout mice. These data suggest that ER81 may be required but is not sufficient for DA neuron differentiation and that CaMKIV is not directly involved in TH gene regulation. J. Comp. Neurol. 502:485–496, 2007. © 2007 Wiley‐Liss, Inc.
Performance Analysis of Raptor Codes under Maximum-Likelihood (ML) Decoding

Raptor codes have been widely used in many multimedia broadcast/multicast applications. However, our understanding of Raptor codes is still incomplete due to the insufficient amount of theoretical work on the performance analysis of Raptor codes, particularly under maximum-likelihood (ML) decoding, which provides an optimal benchmark on the system performance for the other decoding schemes to compare against. For the first time, this paper provides an upper bound and a lower bound, on the packet error performance of Raptor codes under ML decoding, which is measured by the probability that all source packets can be successfully decoded by a receiver with a given number of successfully received coded packets. Simulations are conducted to validate the accuracy of the analysis. More specifically, Raptor codes with different degree distribution and pre-coders, are evaluated using the derived bounds with high accuracy.
The dynamical mass of the young cluster W3 in NGC 7252. Heavy-weight globular cluster or ultra compact dwarf galaxy?

We have determined the dynamical mass of the most luminous stellar cluster known to date, i.e. object W3 in the merger remnant galaxy NGC 7252. The dynamical mass is estimated from the velocity dispersion measured with the high-resolution spectrograph UVES on VLT. Our result is the astonishingly high velocity dispersion of sigma=45 +- 5 km/s. Combined with the large cluster size R_eff=17.5 +-1.8 pc, this translates into a dynamical virial mass for W3 of 8 +- 2 x 10^7 Msun. This mass is in excellent agreement with the value 7.2 x 10^7 Msun we previously estimated from the cluster luminosity M_V=-16.2 by means of stellar M/L ratios predicted by Simple Stellar Population models (with a Salpeter IMF) and confirms the heavy-weight nature of this object. This results points out that the NGC 7252-type of mergers are able to form stellar systems with masses up to ~ 10^8 Msun. We find that W3, when evolved to ~ 10 Gyr, lies far from the typical Milky Way globular clusters, but appears to be also separated from omegaCen in the Milky Way and G1 in M31, the most massive old stellar clusters of the Local Group, because it is too extended for a given mass, and from dwarf elliptical galaxies because it is much more compact for its mass. Instead the aged W3 is amazingly close to the compact objects named ultracompact dwarf galaxies (UCDGs) found in the Fornax cluster (Hilker et al. 1999; Drinkwater et al. 2000), and to a miniature version of the compact elliptical M32. These objects start populating a previously deserted region of the fundamental plane.