Miracle-dz/UniFAR-FTUs huggingface dataset:
Process modeling

• Business process reengineering-the redesign of an organization's business processes to make them more efficient. • Coordination technology-an aid to managing dependencies among the agents within a business process, and provides automated support for the most routinized component processes. * Process-driven software development environments-an automated system for integrating the work of all software related management and staff; it provides embedded support for an orderly and defined software development process. These three applications share a growing requirement to represent the processes through which work is accomplished. To the extent that automation is involved, process representation becomes a vital issue in redesigning work and allocating responsibilities between humans and computers. This requirement reflects the growing use of distributed , networked systems to link the interacting agents responsible for executing a business process. To establish process modeling as a unique area, researchers must identify conceptual boundaries that distinguish their work from model-ing in other areas of information science. Process modeling is distinguished from other types of model-ing in computer science because many of the phenomena modeled must be enacted by a human rather than a machine. At least some mod-eling, however, in the area of human-machine system integration or information systems design has this 'human-executable' attribute. Rather than focusing solely on the user's behavior at the interface or the flow and transformation of data within the system, process model-ing also focuses on interacting behaviors among agents, regardless of whether a computer is involved in the transactions. Much of the research on process modeling has been conducted on software development organizations , since the software engineering community is already accustomed to formal modeling. Software process modeling, in particular , explicitly focuses on phenomena that occur during software creation and evolution, a domain different from that usually mod-eled in human-machine integration or information systems design. Software development is a challenging focus for process modeling because of the creative problem-solving involved in requirements analysis and design, and the coordination of team interactions during the development of a complex intellectual artifact. In this article, software process modeling will be used as an example application for describing the current status of process modeling, issues for practical use, and the research questions that remain ahead. Most software organizations possess several yards of software life cycle description, enough to wrap endlessly around the walls of project rooms. Often these descriptions do not correspond to the processes actually performed during software …
Do You Know the Way to SNA?: A Process Model for Analyzing and Visualizing Social Media Network Data

Traces of activity left by social media users can shed light on individual behavior, social relationships, and community efficacy. Tools and processes to make sense of social traces are essential for enabling practitioners to study and nurture meaningful and sustainable social interaction. Yet such tools and processes remain in their infancy. This paper describes a study of 15 graduate students who were learning to apply Social Network Analysis (SNA) to data from online communities. Their emergent practices were observed via a pre-post survey, diaries, observations, interviews, analysis of assignments and online class interactions, and a group modeling session. From this in-depth look, we derive the Network Analysis and Visualization (NAV) process model and use it to highlight stages where interaction with peers, experts, and features of the SNA tool were most useful. The important role of visualization in supporting networked thinking was essential, as was the iterative nature of goal formation, data structuring, and data analysis. The paper concludes with a discussion of how the NAV model informs the design of SNA tools and services and supports social media practitioners.
Multi-Agent Continuous Transportation with Online Balanced Partitioning: (Extended Abstract)

We introduce the concept of continuous transportation task to the context of multi-agent systems. A continuous transportation task is one in which a multi-agent team visits a number of fixed locations, picks up objects, and delivers them to a final destination. The goal is to maximize the rate of transportation while the objects are replenished over time. Examples of problems that need continuous transportation are foraging, area sweeping, and first/last mile problem. Previous approaches typically neglect the interference and are highly dependent on communications among agents. Some also incorporate an additional reconnaissance agent to gather information. In this paper, we present a hybrid of centralized and distributed approaches that minimize the interference and communications in the multi-agent team without the need for a reconnaissance agent. We contribute two partitioning-transportation algorithms inspired by existing algorithms, and contribute one novel online partitioning-transportation algorithm with information gathering in the multi-agent team. Our algorithms have been implemented and tested extensively in the simulation. The results presented in this paper demonstrate the effectiveness of our algorithms that outperform the existing algorithms, even without any communications between the agents and without the presence of a reconnaissance agent.
Wearable Assistant for Parkinson’s Disease Patients With the Freezing of Gait Symptom

In this paper, we present a wearable assistant for Parkinson's disease (PD) patients with the freezing of gait (FOG) symptom. This wearable system uses on-body acceleration sensors to measure the patients' movements. It automatically detects FOG by analyzing frequency components inherent in these movements. When FOG is detected, the assistant provides a rhythmic auditory signal that stimulates the patient to resume walking. Ten PD patients tested the system while performing several walking tasks in the laboratory. More than 8 h of data were recorded. Eight patients experienced FOG during the study, and 237 FOG events were identified by professional physiotherapists in a post hoc video analysis. Our wearable assistant was able to provide online assistive feedback for PD patients when they experienced FOG. The system detected FOG events online with a sensitivity of 73.1% and a specificity of 81.6%. The majority of patients indicated that the context-aware automatic cueing was beneficial to them. Finally, we characterize the system performance with respect to the walking style, the sensor placement, and the dominant algorithm parameters.
Unmet Health Care Need in US Adolescents and Adult Health Outcomes

BACKGROUND: Adolescence is a formative period when health care services have a unique opportunity to influence later health outcomes. Unmet health care need in adolescence is known to be associated with poor contemporaneous health outcomes; it is unknown whether it predicts poor adult health outcomes. METHODS: We used nationally representative data from 14 800 subjects who participated in Wave I (mean age: 15.9 years [1994/1995]) and Wave IV (mean age: 29.6 years [2008]) of the National Longitudinal Study of Adolescent to Adult Health. Logistic regression models were used to estimate the association between unmet health care need in adolescence and 5 self-reported measures of adult health (fair/poor general health, functional impairment, time off work/school, depressive symptoms, and suicidal ideation). Models were adjusted for baseline health, insurance category, age, gender, race/ethnicity, household income, and parental education. RESULTS: Unmet health care need was reported by 19.2% of adolescents and predicted worse adult health: fair/poor general health (adjusted odds ratio [aOR]: 1.27 [95% confidence interval (CI): 1.00–1.60]); functional impairment (aOR: 1.52 [95% CI: 1.23–1.87]); depressive symptoms (aOR: 1.36 [95% CI: 1.13–1.64]); and suicidal ideation (aOR: 1.30 [95% CI: 1.03–1.68]). There was no significant association between unmet health care need and time off work/school (aOR: 1.13 [95% CI: 0.93–1.36]). Cost barriers accounted for only 14.8% of unmet health care need. The reason for unmet need was not significantly related to the likelihood of poor adult health outcomes. CONCLUSIONS: Reported unmet health care need in adolescence is common and is an independent predictor of poor adult health. Strategies to reduce unmet adolescent need should address health engagement and care quality, as well as cost barriers to accessing services.
Removal of failed crown and bridge

Crown and bridge have life span of many years but they fail for a number of reasons. Over the years, many devices have been designed to remove crowns and bridges from abutment teeth. While the removal of temporary crowns and bridges is usually very straightforward, the removal of a definitive cast crown with unknown cement is more challenging. Removal is often by destructive means. There are a number of circumstances, however, in which conservative disassembly would aid the practitioner in completing restorative/endodontic procedures. There are different mechanisms available to remove a failed crown or bridge. But there is no information published about the classification of available systems for crown and bridge removal. So it is logical to classify these systems into different groups which can help a clinician in choosing a particular type of system depending upon the clinical situation. The aim of this article is to provide a classification for various crown and bridge removal systems; describe how a number of systems work; and when and why they might be used. A PubMed search of English literature was conducted up to January 2010 using the terms: Crown and bridge removal, Crown and bridge disassembly, Crown and bridge failure. Additionally, the bibliographies of 3 previous reviews, their cross references as well as articles published in various journals like International Endodontic Journal, Journal of Endodontics and were manually searched. Key words:Crown and bridge removal, Crown and bridge disassembly, Crown and bridge failure.
White petrolatum (Ph. Eur.) is virtually non‐sensitizing. Analysis of IVDK data on 80 000 patients tested between 1992 and 2004 and short discussion of identification and designation of allergens

Sporadic cases of contact allergy to white petrolatum, which is used as a vehicle in patch test preparations, have been reported. The quantitative relevance of the phenomenon remains yet to be elucidated. Methods: Retrospective analysis of patch test data of the Information Network of Departments of Dermatology (IVDK, http://www.ivdk.org) between 1992 and 2004. Results: Analysis of 79 365 patients patch tested with pure petrolatum yielded 27 ‘+’ (0.03%) and 2 ‘+++’ (0.003%) reactions. The majority of non‐negative reactions (0.3%) was interpreted as doubtful (235) or mild irritant (32). The negative reaction index (RI) (−0.8), and the high positivity ratio (PR) (93%) especially a lack of concordance with patch test preparations containing ≥99% petrolatum indicate that many of the ‘positive’ (+) reactions have to be considered as irritant. There were 2 ‘+++’ reactions. In 1 case, an ‘angry back reaction’ was confirmed. The other case is probably a reading or documentation error, as the majority of patch test reactions to preparations containing petrolatum remained negative in this case also. Conclusions: True allergic patch test reactions to white petrolatum are extremely rare and probably due to an individually increased susceptibility to allergens and/or irritants. This is in agreement with considering petrolatum as a non‐sensitizer.
Shape-changing mobiles: tapering in two-dimensional deformational displays in mobile phones

This paper presents a novel haptic actuation system for mobile phones: Two-dimensional tapering through an actuated back plate. It proposes this type of shape-change for various applications, e.g. for ergonomically actuating the shape itself, displaying internal contents, and pointing to entities located outside the device. The paper reports a user study in which the accuracy of perceiving the two-dimensional tilt of the phone's back plate is measured, as well as results from a questionnaire and a user interview. The results indicate that two-dimensional shape change may be a suitable addition to existing mobile phone technology.
[Expression and significance of N-cadherin and β-catenin protein in osteosarcoma].

OBJECTIVE To evaluate the expression of N-cadherin and β-catenin protein and their relationship with clinicopathological characteristics of osteosarcoma. METHODS The expressions of N-cadherin and β-catenin at protein level were detected by immunohistochemical staining in 54 cases of osteosarcoma, 11 cases of osteoid osteoma, 7 cases of osteoblastoma and 8 cases of newly formed bone in nonmalignant bone diseases. The relationship between the two indexes and clinicopathological characteristics of osteosarcoma was analyzed. RESULTS In newly formed bone, osteoblastoma, osteoid osteoma and osteosarcoma, the positive expression rate of N-cadherin protein was 75.0%, 71.4%, 63.6% and 35.2%, respectively. The positive expression rate of N-cadherin protein in osteosarcoma was significantly lower than that in osteoid osteoma, osteoblastoma and newly formed bone in nonmalignant bone diseases (P = 0.035). The positive expression rate of N-cadherin protein in osteosarcoma cases with pulmonary metastasis was lower than that in cases without (21.7% vs. 56.3%, P = 0.027). The positive expression rate of N-cadherin protein in osteosarcoma cases died in two years was lower than that in cases lived for more than two years (18.2% vs. 50.0%, P = 0.024). In newly formed bone, osteoblastoma, osteoid osteoma and osteosarcoma, the aberrant expression rate of β-catenin protein was 12.5%, 28.6%, 27.3% and 66.7%, respectively. The aberrant expression rate of β-catenin protein in osteosarcoma was significantly higher than that in osteoid osteoma, osteoblastoma and newly formed bone (P = 0.002). Aberrant expression rate of β-catenin in osteosarcoma cases with pulmonary metastasis was higher than that without (82.6% vs. 43.8%, P = 0.011). An inverse correlation was found between the aberrant expression of β-catenin and N-cadherin expression in osteosarcoma(r = -0.302, P = 0.027). CONCLUSION The positive expression rate of N-cadherin is decreased in osteosarcoma while aberrant expression rate of β-catenin increased. The expression of N-cadherin protein is closely correlated with the metastasis and prognosis of osteosarcoma, but the expression of β-catenin protein is merely correlated with the metastasis of osteosarcoma.
Design and test strategies for microarchitectural post-fabrication tuning

Process variations are a major hurdle for continued technology scaling. Both systematic and random variations will affect the critical delay of fabricated chips, causing a wide frequency and power distribution. Tuning techniques adapt the microarchitecture to mitigate the impact of variations at post-fabrication testing time. This paper proposes a new post-fabrication testing framework that accounts for testing costs. This framework uses on-chip canary circuits to capture systematic variation while using statistical analysis to estimate random variation. We derive regression models to predict chip performance and power. These techniques comprise an integrated framework that identifies the most energy efficient post-fabrication tuning configuration for each chip.
Skeletal Muscle Expression of the Adhesion-GPCR CD97: CD97 Deletion Induces an Abnormal Structure of the Sarcoplasmatic Reticulum but Does Not Impair Skeletal Muscle Function

CD97 is a widely expressed adhesion class G-protein-coupled receptor (aGPCR). Here, we investigated the presence of CD97 in normal and malignant human skeletal muscle as well as the ultrastructural and functional consequences of CD97 deficiency in mice. In normal human skeletal muscle, CD97 was expressed at the peripheral sarcolemma of all myofibers, as revealed by immunostaining of tissue sections and surface labeling of single myocytes using flow cytometry. In muscle cross-sections, an intracellular polygonal, honeycomb-like CD97-staining pattern, typical for molecules located in the T-tubule or sarcoplasmatic reticulum (SR), was additionally found. CD97 co-localized with SR Ca2+-ATPase (SERCA), a constituent of the longitudinal SR, but not with the receptors for dihydropyridine (DHPR) or ryanodine (RYR), located in the T-tubule and terminal SR, respectively. Intracellular expression of CD97 was higher in slow-twitch compared to most fast-twitch myofibers. In rhabdomyosarcomas, CD97 was strongly upregulated and in part more N-glycosylated compared to normal skeletal muscle. All tumors were strongly CD97-positive, independent of the underlying histological subtype, suggesting high sensitivity of CD97 for this tumor. Ultrastructural analysis of murine skeletal myofibers confirmed the location of CD97 in the SR. CD97 knock-out mice had a dilated SR, resulting in a partial increase in triad diameter yet not affecting the T-tubule, sarcomeric, and mitochondrial structure. Despite these obvious ultrastructural changes, intracellular Ca2+ release from single myofibers, force generation and fatigability of isolated soleus muscles, and wheel-running capacity of mice were not affected by the lack of CD97. We conclude that CD97 is located in the SR and at the peripheral sarcolemma of human and murine skeletal muscle, where its absence affects the structure of the SR without impairing skeletal muscle function.
Economic investment by ant colonies in searches for better homes

Organisms should invest more in gathering information when the pay-off from finding a profitable resource is likely to be greater. Here, we ask whether animal societies put more effort in scouting for a new nest when their current one is of low quality. We measured the scouting behaviour of Temnothorax albipennis ant colonies when they inhabit nest-sites with different combinations of desirable attributes. We show that the average probability of an ant scouting decreases significantly with an increase in the quality of the nest in which the colony currently resides. This means that the greater the potential gain from finding a new nest, the more effort a colony puts into gathering information regarding new nest-sites. Our results show, for the first time to our knowledge, the ability of animal societies to respond collectively to the quality of a resource they currently have at their disposal (e.g. current nest-site) and regulate appropriately their information gathering efforts for finding an alternative (e.g. a potentially better nest-site).
Spread and Evolution of Respiratory Syncytial Virus A Genotype ON1, Coastal Kenya, 2010–2015

In February 2012, the novel respiratory syncytial virus (RSV) group A, genotype ON1, was detected in Kilifi County, coastal Kenya. ON1 is characterized by a 72-nt duplication within the highly variable G gene (encoding the immunogenic attachment surface protein). Cases were diagnosed through surveillance of pneumonia in children at the county hospital. Analysis of epidemiologic, clinical, and sequence data of RSV-A viruses detected over 5 RSV seasons (2010/2011 to 2014/2015) indicated the following: 1) replacement of previously circulating genotype GA2 ON1, 2) an abrupt expansion in the number of ON1 variants detected in the 2014/2015 epidemic, 3) recently accumulation of amino acid substitutions within the ON1 duplicated sequence, and 4) no clear evidence of altered pathogenicity relative to GA2. The study demonstrates the public health importance of molecular surveillance in defining the spread, clinical effects, and evolution of novel respiratory virus variants.
γ-Tubulin controls neuronal microtubule polarity independently of Golgi outposts

Microtubule orientation controls polarized trafficking in neurons. In this work, γ-tubulin is identified as a key regulator of both axonal and dendritic microtubule polarity. In addition, the idea that γ-tubulin works in dendrites by residing at Golgi outposts is tested.
Herpes Simplex Virus Type 1 Infection Induces the Stabilization of p53 in a USP7- and ATM-Independent Manner

ABSTRACT The major oncoprotein p53 regulates several cellular antiproliferation pathways that can be triggered in response to a variety of cellular stresses, including viral infection. The stabilization of p53 is a key factor in the ability of cells to initiate an efficient transcriptional response after cellular stress. Here we present data demonstrating that herpes simplex virus type 1 (HSV-1) infection of HFFF-2 cells, a low-passage-number nontransformed human primary cell line, results in the stabilization of p53. This process required viral immediate-early gene expression but occurred independently of the viral regulatory protein ICP0 and viral DNA replication. No specific viral protein could be identified as being solely responsible for the effect, which appears to be a cellular response to developing HSV-1 infections. HSV-1 infection also induced the phosphorylation of p53 at residues Ser15 and Ser20, which have previously been implicated in its stabilization in response to DNA damage. However, an HSV-1 infection of ATM−/− cells, which lack a kinase implicated in these phosphorylation events, did not lead to the phosphorylation of p53 at these residues, but nonetheless p53 was stabilized. We also show that the wild-type p53 expressed by osteosarcoma U2OS cells can be stabilized in response to DNA damage induced by UV irradiation, but not in response to HSV-1 infection. These data suggest that multiple cellular mechanisms are initiated to stabilize p53 during an HSV-1 infection. These mechanisms occur independently of ICP0 and its ability to sequester USP7 and may differ from those initiated in response to DNA damage.
Mergeable summaries

We study the mergeability of data summaries. Informally speaking, mergeability requires that, given two summaries on two data sets, there is a way to merge the two summaries into a single summary on the union of the two data sets, while preserving the error and size guarantees. This property means that the summaries can be merged in a way like other algebraic operators such as sum and max, which is especially useful for computing summaries on massive distributed data. Several data summaries are trivially mergeable by construction, most notably all the sketches that are linear functions of the data sets. But some other fundamental ones like those for heavy hitters and quantiles, are not (known to be) mergeable. In this paper, we demonstrate that these summaries are indeed mergeable or can be made mergeable after appropriate modifications. Specifically, we show that for ε-approximate heavy hitters, there is a deterministic mergeable summary of size O(1/ε) for ε-approximate quantiles, there is a deterministic summary of size O(1 over ε log(εn))that has a restricted form of mergeability, and a randomized one of size O(1 over ε log 3/21 over ε) with full mergeability. We also extend our results to geometric summaries such as ε-approximations and εkernels. We also achieve two results of independent interest: (1) we provide the best known randomized streaming bound for ε-approximate quantiles that depends only on ε, of size O(1 over ε log 3/21 over ε, and (2) we demonstrate that the MG and the SpaceSaving summaries for heavy hitters are isomorphic.