Miracle-dz/UniFAR-FTUs huggingface dataset:
Roads and Trade: Evidence from the US

We estimate the effect of interstate highways on the level and composition of trade for us cities. Highways within cities have a large effect on the weight of city exports with an elasticity of approximately 0.5. We find little effect of highways on the total value of exports. Consistent with this, we find that cities with more highways specialize in sectors producing heavy goods.
Targeted neonatal echocardiography in the neonatal intensive care unit: practice guidelines and recommendations for training:.

AAP : American Academy of Pediatrics AEPC : Association for European Paediatric Cardiology ASE : American Society of Echocardiography CDH : Congenital diaphragmatic hernia CHD : Congenital heart disease EAE : European Association of Echocardiography ECMO : Extracorporeal membrane oxygenation EF : Ejection fraction LV : Left ventricular MPI : Myocardial performance index mVCFc : Mean velocity of circumferential fiber shortening NICU : Neonatal intensive care unit PA : Pulmonary artery PDA : Patent ductus arteriosus RA : Right atrial RV : Right ventricular RVSp : Right ventricular systolic pressure SF : Shortening fraction SVC : Superior vena cava TEE : Transesophageal echocardiography TNE : Targeted neonatal echocardiography TVI : Time-velocity integral 2D : Two-dimensional VLBW : Very low birth weight The role of echocardiography in the neonatal intensive care unit (NICU) has changed over the past few years. Previously, nearly all echocardiographic studies in the NICU were performed by pediatric cardiologists to diagnose or monitor congenital heart disease (CHD) and to screen for patent ductus arteriosus (PDA). More recently, neonatologists have become interested in the echocardiographic assessment of hemodynamic instability in infants. The terms functional echocardiography and point-of-care echocardiography have been introduced to describe the use of echocardiography as an adjunct in the clinical assessment of the hemodynamic status in neonates.1–4 The increasing availability of echocardiography, with miniaturization of the technology, has resulted in more widespread use of echocardiography in NICUs around the world.5 Perhaps the most significant challenge for the application of so-called functional studies is that newborns in the NICU with hemodynamic instability are at a much higher risk for having underlying CHD. In addition, newborns in the NICU are unique in that they are in the process of …
Development of Pavement Performance Models by Combining Experimental and Field Data

The objective of this paper is to demonstrate the development of pavement performance models by combining experimental and field data. A two step approach was used. In the first step a riding quality model based on serviceability consideration is developed. The data set of the American Association of State Highways Officials (AASHO) Road Test is used to this effect. Due to the experimental nature of the AASHO Road Test data set, some of the estimated parameters of the model may be biased when the model is to be applied to predict performance in the field. In the second step, the original model parameters are reestimated by applying joint estimation allowed for with the incorporation of field data set. This data set was collected through the Minnesota Road Research Project (MnRoad). The final model is referred to as the joint model, and it can be used to predict the performance of in-service pavement sections. Joint estimation allowed for the full potential of both data sources to be exploited. First, the effect of variables not available in the first data source were identified and quantified. Further, the parameter estimates had lower variance because multiple data sources were pooled, and biases in the parameters of the experimental model were corrected. Finally, different measurements of the same property were incorporated by using a measurement error model. Thus, the methodology proposed in this paper makes optimum use of available data and yields models of improved statistical properties compared with techniques such as ordinary least squares.
How do prior outcomes affect risk attitude

Modelling choice in multi-period asset pricing requires assumptions about how prior outcomes affect risk attitude. We present an experimental study of the influence of prior outcomes on risky choice. We document a strong framing effect. By manipulating the presentation format of the decision problem we can induce increased risk taking following a gain, i.e. the house-money effect (Thaler and Johnson 1990) or, alternatively, increased risk taking following a loss, i.e. escalation of commitment (Staw 1976). Maximization of a value function from prospect theory can explain some of our results. Escalation of commitment in our experiment does not appear to be driven by a need to justify or rationalize the initial decision.
Predictors of non-responding in short-term psychodynamic group therapy

Abstract Selection for psychotherapy may be improved by identifying predictors of non-responding to treatment, but there are only few studies of non-responding in short-term psychodynamic group therapy. We analyzed potential socio-demographic and clinical predictors in a sample of 239 patients in 39 sessions of psychodynamic group psychotherapy, including self-reported symptoms, personality, and extra-therapeutic events. Non-responding was assessed by the Symptom Check List-90-Revised Global Severity Index (SCL-90-R GSI) according to Jacobson and Truax’s Reliable Change Index. Non-responders represented 44.8% of the sample and these patients were still significantly higher in symptom load at a one-year follow-up. SCL-90-R Interpersonal Sensitivity, Compulsive personality as assessed by Millon Clinical Multiaxial Inventory-II (MCMI-II), adverse life events during the course of treatment (e.g. somatic illness, loss of partner or job), lack of social support, social burden and occupation were all significantly associated with non-responding in the bivariate analyses. However, in the multivariate analysis only adverse life events reached significance, and Interpersonal Sensitivity marginal significance, explaining 12.0% of variance. When only pre-treatment variables were included, Interpersonal sensitivity and MCMI Compulsive personality predicted non-responding. Adverse life events may indicate a need for re-evaluation of the treatment plan. Exclusion of these patients (17.6%) revealed lack of social support, low MCMI Passive–Aggressive personality scores, and presence of SCL-90-R Somatization symptoms to predict non-responding. Social support and scores on symptom and personality disorder scales, which indicate awareness of problems related to the interpersonal domain, may be highly relevant to explore before selection of patients to short-term time-limited psychodynamic group therapy.
Simulation Model for Composting Cellulosic (Bagasse) Substrates

A dynamic model of aerobic composting with solid substrates was developed as a first step to predict the rate of decomposition of cellulosic materials. The model was based on heat and mass transfer principles and reaction kinetics of biological processes. The relations describing the rates of reaction and the degradability potential of the substrates were determined based on laboratory-scale experiments. The model was developed using a graphical software package, Stella II® (which was able to solve feedback loops encountered in actual composting processes.The model was validated with temperature, oxygen distribution and mass degradation accompanying the composting of bagasse. Experimental setups consisted of 30 gallon drum reactors, continuously aerated. Temperature and oxygen in exhaust gases were monitored on an hourly basis and measurements of moisture content, pH and volatile solids were done on a weekly basis.The data fit with the model was excellent for mass degraded and temperatures for the first 1.
Wanting, having, and needing: integrating motive disposition theory and self-determination theory.

Four studies explored the motivational and experiential dynamics of psychological needs, applying both self-determination theory and motive disposition theory. In all 4 studies, motive dispositions toward achievement and affiliation ("wanting" particular experiences) predicted corresponding feelings of competence and relatedness ("having" those experiences). Competence and relatedness in turn predicted well-being, again indicating that these 2 experiences may really be "needed. " Illuminating how wanting gets to having, in Studies 2 and 3, participants reported greater self-concordance for motive-congruent goals, which, in longitudinal Study 3, predicted greater attainment of those goals and thus enhanced well-being. Study 4 replicated selected earlier results using an implicit as well as an explicit motive disposition measure. Supporting the presumed universality of competence and relatedness needs, in no studies did motive dispositions moderate the effects of corresponding need-satisfaction on well-being. Discussion focuses on a "sequential process" model of psychological needs that views needs as both motives that instigate and outcomes that reward behavior.
Equilibrium Asset Pricing under Heterogeneous Information Equilibrium Asset Pricing under Heterogeneous Information

We analyze theoretically and empirically the implications of heterogeneous information for equilibrium asset pricing and portfolio choice. Our theoretical framework, directly inspired by Admati (1985), implies that with partial information aggregation, portfolio separation fails, buy-and-hold strategies are not optimal, and investors should structure their portfolios using the information contained in prices in order to mitigate a winner’s curse. We implement empirically such portfolio allocation strategies and show they outperform economically and statistically passive/indexing buy-and-hold strategies. We thus demonstrate empirically how prices reveal information, in contrast with the homogeneous information CAPM. However, our findings also imply that, consistent with Noisy Rational Expectations Equilibrium, prices do not fully aggregate information.
Formation of giant globular cluster G1 and the origin of the M 31 stellar halo

We demonstrate that globular cluster G1 could have been formed by tidal interaction between M 31 and a nucleated dwarf galaxy (dE,N). Our fully self-consistent numerical simulations show that during tidal interaction between M 31 and G1's progenitor dE,N with MB ∼− 15 mag and its nucleus mass of ∼10 7 M� , the dark matter and the outer stellar envelope of the dE,N are nearly completely stripped whereas the nucleus can survive the tidal stripping because of its initially compact nature. The naked nucleus (i.e., G1) has orbital properties similar to those of its progenitor dE,N. The stripped stars form a metal-poor ((Fe/H) ∼− 1) stellar halo around M 31 and its structure and kinematics depend strongly on the initial orbit of G1's progenitor dE,N. We suggest that the observed large projected distance of G1 from M 31 (∼40 kpc) can give some strong constraints on the central density of the dark matter halo of dE,N. We discuss these results in the context of substructures of M 31's stellar halo recently revealed by Ferguson et al. (2002).
Development of an IgY Antibody-Based Immunoassay for the Screening of the CYP2E1 Inhibitor/Enhancer from Herbal Medicines

Cytochrome P450 (CYP) 2E1 is an important enzyme involved in the metabolism of many endogenous and exogenous compounds. It is essential to evaluate the expression of CYP2E1 in the studies of drug–drug interactions and the screening of drugs, natural products, and foodstuffs. The present work is a feasibility study on the development of immunoassays using a specific and sensitive chicken-sourced anti-CYP2E1 IgY antibody. Cloning, expression, and purification of a recombinant CYP2E1 (mice origin) protein were carried out. Anti-CYP2E1 IgY antibodies were generated by immunizing white Leghorn chickens with purified recombinant CYP2E1 protein and were purified by immune affinity chromatography. The IgY titer attained a peak level (≥1:128,000) after the fifth booster injection. For evaluation of the expression of CYP2E1 in different herbal treatment samples, the mice were treated by oral gavage for 3 days with alcohol (50% 15 mL/kg), acetaminophen (APAP, 300 mg/kg), Cornus officinalis extract (100 mg/kg), Alhagi-honey extract (100 mg/kg), Apocynum venetum extract (100 mg/kg), hyperoside (50 mg/kg), isoquercetin (50 mg/kg), 4-hydroxyphenylacetic acid (50 mg/kg), 3-hydroxyphenylacetic acid (50 mg/kg), and 3,4-hydroxyphenylacetic acid (50 mg/kg). The expression of CYP2E1 was determined by Western blot analysis, immunohistochemistry, ELISA, and immunomagnetic beads (IMBs) using anti-CYP2E1 IgY in liver tissue. The results showed that C. officinalis extract, Alhagi-honey extract, A. venetum extract, hyperoside, isoquercetin, and their xenobiotics 4-hydroxyphenylacetic acid, 3-hydroxyphenylacetic acid, and 3,4-hydroxyphenylacetic acid significantly decreased CYP2E1 levels. Alcohol and APAP treatments significantly increased CYP2E1 levels as analyzed with Western blot analysis, immunohistochemistry, and ELISA. The IMB method is suitable for large-scale screening, and it is a rapid screening (20 min) that uses a portable magnet and has no professional requirements for the operator, which makes it useful for on-the-spot analysis. Considering these results, the anti-CYP2E1 IgY could be applied as a novel research tool in screening for the CYP2E1 inhibitor/enhancer.
Montanoa frutescens and Montanoa grandiflora Extracts Reduce Anxiety-Like Behavior during the Metestrus-Diestrus Phase of the Ovarian Cycle in Wistar Rats

In previous studies, the anxiolytic-like effects of Montanoa tomentosa and Montanoa frutescens were reported in male rats, but the potential anxiolytic-like effects of Montanoa plants during the different phases of the ovarian cycle in rats remain to be explored. The anxiolytic-like effects of the aqueous crude extracts of M. frutescens (25 and 50 mg/kg) and M. grandiflora (25 and 50 mg/kg) in the elevated plus maze were investigated in Wistar rats during the estrous cycle and compared with 2 mg/kg diazepam as a reference anxiolytic drug. To investigate any motor effect (i.e., hyperactivity, no changes, or hypoactivity) associated with the treatments, the rats were evaluated in the open field test. The M. frutescens (25 and 50 mg/kg) and M. grandiflora (50 mg/kg) extracts exerted anxiolytic-like effects during the metestrus-diestrus phase, similar to diazepam, without disrupting spontaneous motor activity. No significant effects of the extracts were detected in either behavioral test during the proestrus-estrus phase, whereas diazepam produced motor hypoactivity in the open field test. These results indicate that the M. frutescens and M. grandiflora extracts possess anxiolytic-like effects that depend on the ovarian cycle phase, supporting the Mexican ancient medicinal use of these plants to ameliorate anxiety disorders.
The origin of Intermediate and Subpolar Mode Waters crossing the Atlantic equator in OCCAM

The origin of the intermediate waters that cross the equatorial Atlantic as part of the return flow for North Atlantic Deep Water was studied in a high resolution global ocean model using a Lagrangian particle following technique. Most of these waters are subducted in the southeast Indian Ocean. Less than twenty percent comes directly from Drake Passage without looping into the Indian Ocean; the majority being provided by Agulhas leakage. Most of the intermediate waters that subduct in the South Atlantic do not follow the South Atlantic/Indian Ocean supergyre, but remain within the Antarctic Circumpolar Current, and gradually transform into Circumpolar Deep Water by diapycnal mixing.
Second Round Results of the Finnish Population-Based Prostate Cancer Screening Trial

Purpose: Large randomized trials provide the only valid means of quantifying the benefits and drawbacks of prostate-specific antigen (PSA) screening, but the follow-up of ongoing studies is still too short to allow evaluation of mortality. We report here the intermediate indicators of screening efficacy from the second round of the Finnish trial. Experimental Design: The Finnish trial, with ∼80,000 men in the target population, is the largest component in the European Randomized Study of Screening for Prostate Cancer. The first round was completed in 1996–1999. Each year 8,000 men 55–67 years of age were randomly assigned to the screening arm, and the rest formed the control arm. Men randomized to the screening arm in 1996 were reinvited 4 years later, in 2000, and PSA was determined. Results: Of the eligible 6415 men, 4407 (69%) eventually participated in the second round of screening. Of the first-round participants, up to 84% (3833 of 4556) attended rescreening. A total of 461 screenees (10.5%) had PSA levels of ≥4 μg/liter. Altogether, 97 cancers were found, yielding an overall detection rate of 2.2% (97 of 4407). Seventy-nine cases were found among the 3833 second-time screenees (detection rate 2.1%) and 18 in those 574 men (3.1%) who had not participated previously. A PSA of ≥4 μg/liter, but negative biopsy in the first screening round was associated with an up to 9-fold risk of cancer in rescreening relative to those with lower PSA levels at baseline. Ninety-one (94%) of all of the detected cancers were clinically localized. Conclusions: As surrogate measures of an effective screening program, both compliance as well as the overall and advanced prostate cancer detection rates remained acceptable. Men defined as screen-positive but with a negative confirmation of cancer at prevalence screen formed a high-risk group at rescreening.
Speeding up LFG Parsing Using C-Structure Pruning

In this paper we present a method for greatly reducing parse times in LFG parsing, while at the same time maintaining parse accuracy. We evaluate the methodology on data from English, German and Norwegian and show that the same patterns hold across languages. We achieve a speedup of 67% on the English data and 49% on the German data. On a small amount of data for Norwegian, we achieve a speedup of 40%, although with more training data we expect this figure to increase.
Exact Solution of the One-Dimensional Non-Abelian Coulomb Gas at Large N.

The problem of computing the thermodynamic properties of a one-dimensional gas of particles which transform in the adjoint representation of the gauge group and interact through non-Abelian electric fields is formulated and solved in the large {ital N} limit. The explicit solution exhibits a first order confinement-deconfinement phase transition with computable properties and describes two-dimensional adjoint QCD in the limit where matter field masses are large. {copyright} {ital 1996 The American Physical Society. }
International Journal of Behavioral Nutrition and Physical Activity Television Viewing, Computer Use, Obesity, and Adiposity in Us Preschool Children

Background: There is limited evidence in preschool children linking media use, such as television/ video viewing and computer use, to obesity and adiposity. We tested three hypotheses in preschool children: 1) that watching > 2 hours of TV/videos daily is associated with obesity and adiposity, 2) that computer use is associated with obesity and adiposity, and 3) that > 2 hours of media use daily is associated with obesity and adiposity.
The Impact of Software Development Team Dynamics on the Knowledge Management Process(S)

The influence of software team dynamics on well- organized software development knowledge process could prevent software development organizations from suffering from the knowledge atrophy problem. To explore this, we have studied several team dynamics factors that influence the Knowledge Management Processes (KMP) in Very Small Entities (VSEs) [1]. A survey was conducted in a variety of VSEs and through statistical and qualitative content analysis for the research data, results indicate that small teams, informal team process and structure have an important influence on the level of team dynamics in the software development process
Adult Conditional Knockout of PGC-1α Leads to Loss of Dopamine Neurons

Visual Abstract Parkinson’s disease (PD) is a chronic progressive neurodegenerative disorder. Recent studies have implicated a role for peroxisome proliferator-activated receptor γ coactivator protein-1α (PGC-1α) in PD and in animal or cellular models of PD. The role of PGC-1α in the function and survival of substantia nigra pars compacta (SNpc) dopamine neurons is not clear. Here we find that there are four different PGC-1α isoforms expressed in SH-SY5Y cells, and these four isoforms are expressed across subregions of mouse brain. Adult conditional PGC-1α knock-out mice show a significant loss of dopaminergic neurons that is accompanied by a reduction of dopamine in the striatum. In human PD postmortem tissue from the SNpc, there is a reduction of PGC-1α isoforms and mitochondria markers. Our findings suggest that all four isoforms of PGC-1α are required for the proper expression of mitochondrial proteins in SNpc DA neurons and that PGC-1α is essential for SNpc DA neuronal survival, possibly through the maintenance of mitochondrial function.
The Persistence of Profits in the Long Run: A New Approach

Abstract We present a trend‐based alternative to the standard first‐order autoregression model in persistence of profits studies. This is motivated by reservations over the interpretation of the standard model, and rests on a different concept of dynamic competition. A nine‐category taxonomy of long‐run persistence stereotypes is developed. Structural time series estimates are presented for a sample of UK companies. We find the null of long run competitive equilibrium not rejected in nearly a third of cases, but non‐eroding persistence to be present in around 60%.
Leukocyte Telomere Length and Cognitive Function in Older Adults

We evaluated the specific association between leukocyte telomere length and cognitive function among a national sample of the broader U.S. older adult population. Data from the 1999-2002 National Health and Nutrition Examination Survey (NHANES) were used to identify 1,722 adults, between 60-85 years, with complete data on selected study variables. DNA was extracted from whole blood via the LTL assay, which is administered using quantitative polymerase chain reaction to measure telomere length relative to standard reference DNA (T/S ratio). Average telomere length was recorded, with two to three assays performed to control for individual variability. The DSST (Digit Symbol Substitution Test) was used to assess participant executive cognitive functioning tasks of pairing and free recall. Individuals were excluded if they had been diagnosed with coronary artery disease, congestive heart failure, heart attack or stroke at the baseline assessment. Leukocyte telomere length was associated with higher cognitive performance, independent of gender, race-ethnicity, physical activity status, body mass index and other covariates. In this sample, there was a strong association between LTL and cognition; for every 1 T/S ratio increase in LTL, there was a corresponding 9.9 unit increase in the DSST (β = 9.9; 95% CI: 5.6-14.2; P