Miracle-dz/UniFAR-FTUs huggingface dataset:
Readying the head and steadying the heart: a review of cortical and cardiac studies of preparation for action in sport

Expert sport stars reliably execute their skills with remarkable precision and accuracy. To provide an insight into the mechanisms that underpin the superior performance of experts compared to novices, this article critically reviews experiments that have examined cortical activity (i.e., movement related cortical potentials; EEG spectral power) and cardiac activity (i.e., dynamic changes in heart rate) during preparation for action in self-paced aiming sports. It suggests that decelerations in heart rate and task-specific changes in EEG activity during preparation for action can explain superior expert performance. These psychophysiological responses are interpreted in terms of preparatory information processing and response programming, before suggestions for future research into the psychophysiology of preparation for action are outlined.
Serum adiponectin levels, insulin resistance, and lipid profile in children born small for gestational age are affected by the severity of growth retardation at birth.

OBJECTIVE Insulin resistance has been linked to intrauterine growth retardation (IUGR); adiponectin is a protein with insulin-sensitizing properties. This study was designed to test whether being born small for gestational age (SGA) has an effect on blood levels of adiponectin and leptin, insulin resistance parameters, and lipid profile in pre-puberty, taking into consideration the severity of IUGR. METHODS Serum levels of adiponectin, leptin, total cholesterol (t-CHOL), high density lipoprotein (HDL)-cholesterol, low density lipoprotein (LDL)-cholesterol, triglycerides, apolipoproteins A-1 (Apo A-1), Apo B and Apo E, lipoprotein(a) (Lp(a)), fasting glucose, and insulin (Ins), the homeostasis model assessment insulin resistance index (HOMA-IR) and anthropometric indices were evaluated in 70 children aged 6-8 years, born appropriate for gestational age (AGA; n = 35) and SGA (n = 35), matched for age, gender, height, and BMI. SGA children were divided into two subgroups according to the severity of IUGR: SGA<3rd percentile (n = 20), and SGA 3rd-10th percentile (n = 15). They were also subdivided in two subgroups, those with (n = 25) and those without (n = 10) catch-up growth, considering their actual height corrected for mid-parental height. RESULTS SGA children had higher Ins and HOMA-IR than AGA children (Ins, 42 +/- 23 vs 32 +/- 11 pmol/l; HOMA-IR, 1.30 +/- 0.8 vs 0.92 +/- 0.3; P<0.05). No significant difference in serum leptin was found between the SGA and the AGA groups but adiponectin showed a trend to be higher in SGA children (13.6 +/- 5.7 vs 10.8 +/- 5.9 microg/ml respectively). SGA children without catch-up growth had higher adiponectin (15.6 +/- 8.5 microg/ml, P<0.05) than AGA children. Among the SGA children, the subgroup <3rd percentile had higher Lp(a) than the subgroup 3rd-10th percentile (P<0.05). An independent positive correlation between adiponectin and Lp(a) was observed in SGA children (R = 0.59, P<0.01). CONCLUSION SGA children, although more insulin resistant, had similar or higher adiponectin levels than matched AGA children in pre-puberty. The severity of IUGR appears to affect their metabolic profile during childhood.
Rethinking Hegemony and Resistance to Political Education in Mainland China and Hong Kong

The focus of this article is on Hong Kong and mainland Chinese university student reactions, in two time periods, to national themes in education as part of state attempts to establish and maintain legitimacy. I argue that among these reactions is one of resistance to the process of state hegemony. To make this point, the article builds on several arguments derived from the literature on citizenship education in mainland China and in colonial and postcolonial Hong Kong. According to these arguments, national themes were neglected in civic education in colonial Hong Kong but gained prominence within educational policy discourse with the return of the territory to Chinese sovereignty in 1997 (Morris 1997; Law 2004; Fairbrother 2005b). By contrast, national themes were particularly prominent in 1990s mainland Chinese political education, but they were accompanied in a later broadening of political education discourse by themes related to legality, such as understandings of rule by law, due process, and individual rights. Relevant also is that the mainland Chinese state’s attention to nationality in 1990s education was associated with a newly emphasized claim to legitimacy on the basis of representing and promoting patriotism (Ding 1994; Zhao 1998). By the early 2000s, however, new ideologies based on the claims of the Chinese Communist Party (CCP) to represent all sectors of society and to promote individual rights and rule by law supplemented justifications for legitimacy based on nationality. In Hong Kong, the colonial state’s claims to legitimacy were based on a high degree of public consultation in governance and the provision of social services but most importantly on maintaining social stability, which potentially could be damaged if Chinese nationality were actively promoted in society and schooling. While the Hong Kong Special Administrative
Case-control analysis of cochlear implant performance in elderly patients.

OBJECTIVE To characterize speech perception performance in elderly cochlear implant users compared with younger adult users. DESIGN Case-control retrospective analysis from January 1, 1999, to January 28, 2008. SETTING Tertiary care, academic practice cochlear implant program. PATIENTS Medical records for 78 patients with age at implantation of 65 years or older were analyzed for ear-specific preimplantation speech perception performance, length of deafness, age at implantation, and 1-year postimplantation speech perception performance. A subset of 28 elderly patients with complete data was matched to 28 younger adult patients (age at implantation, 18-64 years) for preimplantation performance using the Hearing in Noise Test-Quiet scores (mean, 22% and 23%, respectively). MAIN OUTCOME MEASURE One-year postimplantation performance on word and sentence testing. RESULTS Within the elderly cohort, the Consonant-Nucleus-Consonant and Hearing in Noise Test-Quiet scores were not affected by age. The Hearing in Noise Test-Noise scores trended downward with increasing age but did not reach statistical significance (P = .052). Of the matched older and younger patients, 55 of 56 showed improvement in their 1-year postimplantation compared with preimplantation Hearing in Noise Test-Quiet scores, with better preimplantation performance predictive of better postimplantation performance, independent of age at implantation (P = .02). Group comparisons, however, revealed poorer postimplantation scores overall for the elderly patients compared with the younger ones for the Hearing in Noise Test-Quiet (70% vs 83%; P = .02) and the Consonant-Nucleus-Consonant test (38% vs 53%; P = .02). CONCLUSIONS Elderly patients benefit significantly from cochlear implantation. Compared with a younger cohort matched for preimplantation performance, however, their postimplantation scores are significantly lower on some measures. These results may provide guidelines for candidacy and counseling regarding elderly patients with cochlear implants.
The Effect of Metal Cation Binding on the Protein, Lipid and Retinal Isomeric Ratio in Regenerated Bacteriorhodopsin of Purple Membrane ¶

The effect of metal cation binding on bacteriorhodopsin (bR) in purple membrane has been examined using in situ attenuated total reflection‐Fourier transform infrared difference spectroscopy in aqueous media. It is known that adding metal cations to deionized bR regenerates the purple state from its blue state and recovers the proton pump function. During this process, infrared spectral changes in the frequency region of 1800–1000 cm−1 are monitored. The results reveal that metal cation binding affects the protein conformation, the retinal isomeric composition as well as lipid head groups. It is also observed that metal cation binding induces conformational changes in the αI‐helix region of bR, converting the portion of its αI‐helical domain into β‐turn or disordered coil. In addition, the influence of Ho3+ binding on the protein and lipid is observed to be larger than that of Ca2+. These results suggest that some of the metal cation binding sites are on the membrane lipid domain, while others could be on the intrahelical domain or interhelical loops where the Asp and Glu are located (binding with their COO− groups). Our results also suggest that the removal of the C‐terminal of bR increase the accessibility of the binding site of metal cations, which affects protein conformational structure. All these observations are discussed in terms of the two proposals given in the literature regarding the metal cation binding sites.
A Comparison of the Physical, Chemical, and Biological Properties of Sludges from a Complete‐Mix Activated Sludge Reactor and a Submerged Membrane Bioreactor

The properties of sludges from a pilot‐scale submerged membrane bioreactor (SMBR) and two bench‐scale complete‐mix, activated sludge (CMAS) reactors treating municipal primary effluent were determined. Compared with the CMAS sludges, the SMBR sludge contained a higher amount of soluble microbial products (SMP) and colloidal material attributed to the use of a membrane for solid–liquid separation; a higher amount nocardioform bacteria, resulting from efficient foam trapping; and a lower amount of extracellular polymeric substances (EPS), possibly because there was no selective pressure for the sludge to settle. High aeration rates in both the CMAS and SMBR reactors produced sludges with higher numbers of smaller particles. Normalized capillary suction time values for the SMBR sludge were lower than for the CMAS sludges, possibly because of its lower EPS content.
Demonstration of retrogradely transported endogenous nerve growth factor in axons of sympathetic neurons

The presence of retrogradely transported endogenous nerve growth factor (NGF) in sympathetic nerves of the guinea pig was demonstrated directly by fluorescent and peroxidase immunohistochemistry in the ligated superior postganglionic nerve of the superior cervical ganglion. Fixed, frozen sections of previously ligated nerve were incubated with either rabbit antiserum against guinea pig NGF (gpNGF), rabbit antibodies against gpNGF purified on a mouse NGF (mNGF) affinity column, the portion of rabbit antiserum against gpNGF that did not bind to the mNGF affinity column, or nonimmune rabbit serum. Positive staining on the peripheral side of the ligation was obtained only with unfractionated antiserum against gpNGF and with purified antibodies against gpNGF. The staining properties of the various antiserum preparations correlated with their ability to block gpNGF- and mNGF-induced neurite outgrowth in the embryonic chick dorsal root ganglion bioassay and in the PC12 bioassay. Homogenates of superior postganglionic nerve supported growth of embryonic chick dorsal root ganglia and differentiation of PC12 cells. This support was blocked by the specific antisera against NGF used in the immunohistochemistry experiments. These experiments demonstrate that endogenous NGF, presumably released by peripheral target tissues, is retrogradely transported in vivo.
Intersection of effort and risk: ethological and neurobiological perspectives

The physical effort required to seek out and extract a resource is an important consideration for a foraging animal. A second consideration is the variability or risk associated with resource delivery. An intriguing observation from ethological studies is that animals shift their preference from stable to variable food sources under conditions of increased physical effort or falling energetic reserves. Although theoretical models for this effect exist, no exploration into its biological basis has been pursued. Recent advances in understanding the neural basis of effort- and risk-guided decision making suggest that opportunities exist for determining how effort influences risk preference. In this review, we describe the intersection between the neural systems involved in effort- and risk-guided decision making and outline two mechanisms by which effort-induced changes in dopamine release may increase the preference for variable rewards.
Risk Perceptions of Mobile Phone Use While Driving

Numerous governments have introduced regulations governing the use of mobile (cellular) telephones while driving. Despite significant research into the “objective” risks, there is relatively little research into risk perceptions either in relation to other in‐car distractions or with respect to the factors underlying such perceptions. The current article reports on two studies addressing these issues. Study 1 (N= 199) found that whereas the use of hand‐held sets is seen as one of the riskiest activities to perform while driving, the risks of using a hands‐free kit are perceived to be relatively small. Study 2 (N= 1,320) found that nearly half of all drivers in the sample with a mobile phone reported having used it while driving and that, overall, the probability of having an accident was perceived to be less for oneself than for one's peers, indicating an optimistic bias. Two factors underpinned risk perceptions, “impact” including perceived severity and equitability, and “controllability” including immediacy, detectability, and probability. While higher “impact” scores were associated with increased preferences for restrictions on the use of hand‐held mobiles while driving, the “controllability” scores moderated this relationship such that when perceived “controllability” was low, restriction preferences were high irrespective of perceived “impact. ” However, when “controllability” was high, restriction preferences remained high when “impact” was high but were low when “impact” was low. Given the growing number of in‐car technological innovations, it is suggested that regulators act strategically, rather than finding themselves developing a series of “hazard‐specific” regulations, which may ultimately lack coherence.
Cultural Learning Processes through Local Wisdom: A Case Study on Adult and Lifelong Learning in Thailand

This article provides the background and concept of Thailand Lifelong Learning [LLL], even attempting a definition. The Thai LLL vision encompasses strategies for developing human qualities such as integrity, self-reliance, adaptability, resilience, and spirituality, to name a few. In some regards LLL seeks to recapture a more fully-developed perspective, on what in earlier times and places [1238 AD in Thailand], was called 'indigenous education', as it now pursues the benefits of a vibrant Learning Society. Progress of LLL in Thailand at times seems to be very slow and methodological rather than dynamic. It stems from developing a policy of learning processes for establishing solid education systems-Formal, Non-Formal, and Informal. LLL also has developed by means of garnering and integrating 'Local Wisdom' [a Thai term designating important valued human experience] into what has become known as 'cultural learning processes'. This Local Wisdom is held by 'Wisdom Teachers' and encompasses nine areas, as follows: agriculture, handicraft/cottage industry, traditional medicine, conservation of natural resources, funding/community economics, fine arts, languages/literatures, philosophy/religion/tradition, and food/nutrition. Government Organizations and Private Non-Governmental Organizations have strongly supported and have been major forces for advancing cultural learning, LLL, and what may be labeled as a 'Learning Society'. In addition, collaboration between Chulalongkorn University, Bangkok [Thailand's premier university] and Lindenwood University, St. Charles, Missouri, USA, has helped Thai LLL advance immeasurably and move toward becoming a Learning Society from 2010 to 2015. Added to this, and provided a Model of Cultural Learning, with recommendations for improvement at the National and Community levels. It concludes with assurances toward its creating diversity within the constituencies to be served, strengthening a self-sufficient economy, solidifying moral values, and enhancing Thailand's becoming a vibrant and flourishing Lifelong Learning Society.
Regression of L-NAME–Induced Hypertension: The Role of Nitric Oxide and Endothelium-Derived Constricting Factor

NG-Nitro-L-arginine-methyl ester (L-NAME)–induced hypertension is a well established model of experimental hypertension. Although regression experiments are effective at approximating a clinical setting the reversal of already established L-NAME hypertension has not been intensively researched. We investigated whether spontaneous regression of L-NAME hypertension after discontinuing the drug administration was associated with recovery of endothelial dysfunction. Special attention was devoted to NO signaling and endothelium-derived constricting factor (EDCF) formation in various parts of the vascular tree. Male adult Wistar rats were divided into 4 groups: an L-NAME (5 weeks), a spontaneous recovery (5 weeks L-NAME + 3 weeks of recovery) and two age-matched control groups (a 5- and 8-week control group). The NO-mediated and EDCF-mediated components of acetylcholine-induced responses were evaluated in preconstricted small mesenteric and femoral arteries. The activity, mRNA and protein expression of NO synthase together with the mRNA expression of cyclooxygenase were determined in the aorta. L-NAME administration caused hypertension, impaired NO signaling (as indicated by the reduced NO component of acetylcholine-induced relaxation and decreased NO synthase activity) in all arteries investigated and reduced the inner diameter of the femoral artery. Moreover, we observed enhanced cyclooxygenase-dependent EDCF formation in the femoral arteries and enhanced cyclooxygenase-2 expression in the aortas of L-NAME–treated rats. During spontaneous recovery a functional restoration of NO signaling took place in all parts of the vascular tree. However, the increases in systolic blood pressure, EDCF formation, and cyclooxygenase expression and the reduction in femoral artery diameter were not completely restored. We conclude that impaired NO signaling was improved after the cessation of L-NAME administration. However, persisting arterial structural alterations and enhanced EDCF formation may decelerate blood pressure reduction even after the restoration of NO synthase activity.
High Dietary Sodium Blunts Effects of Angiotensin-converting Enzyme Inhibition on Vascular Angiotensin I–to–Angiotensin II Conversion in Rats

High sodium intake blunts the efficacy of angiotensin (Ang)-converting enzyme (ACE) inhibition (ACEi), but the underlying mechanism is incompletely characterized. High sodium has been reported to increase vascular expression and vascular activity of ACE. To investigate whether high-dietary sodium–induced effects on vascular conversion of Ang I might be involved in the sodium-induced blunting of the response to ACEi, the authors studied the vasoconstrictor responses to Ang I and Ang II of isolated aortic rings from healthy rats on low dietary sodium (LS: 0.05% NaCl) and high dietary sodium (HS: 2.0% NaCl) after 3 weeks of ACEi (lisinopril 75 mg/L) or vehicle (CON). Blood pressure was similar in LS and HS in CON, but HS blunted the blood pressure response to ACEi. Functional conversion of Ang I was assessed as the difference in dose–response curves to Ang I and Ang II in parallel aortic rings. Sodium intake did not affect the dose–response curves to Ang I and Ang II in CON. In the ACEi groups, a significant difference was present between the curves for Ang I and Ang II on LS (&Dgr;EC50, 6.7 n M; range, 2.2–13 n M; P < 0.01) but not on HS (&Dgr;EC50: 1.3 n M; range, 0.0–4.1 n M, median [interquartile range], NS). Thus, HS blunts the ACEi-induced reduction of functional vascular Ang I conversion compared with LS. Whether the blunted functional vascular conversion is causally related to the blunted blood pressure response remains to be elucidated.
Humanizing and feminizing school science: reviving anthropomorphic and animistic thinking in constructivist science education

Science and scientists in general reject any form of animism or anthropomorphism. Meanwhile, there is considerable evidence that these forms of thinking are quite commonly present in the constructions and causal explanations of both children and adults as they try to make sense of their everyday world. The question is: can animistic and anthropomorphic ways of thinking have any positive value in school science? This article addresses four distinctive but linked issues within the broad context of constructivist science education. The first concerns the mismatch between animistic thought and the ‘mechanistic’ world‐view of orthodox science. The second examines the extent to which such ways of thinking are manifest and their relationship to general constructivist theory. The third explores briefly some classroom and textbook examples in use. The fourth explores some implications of this for instruction in science education. Within this, the article is premised on the notion that the mechanistic nature of sci.
High ambient temperature increases intravenous methamphetamine self-administration on fixed and progressive ratio schedules in rats

Methamphetamine is a drug that is often consumed at dance parties or nightclubs where the ambient temperature is high. The present study determined whether such high ambient temperatures alter intravenous methamphetamine self-administration in the rat. Male Hooded Wistar rats were trained to self-administer intravenous methamphetamine (0.1 mg/kg/infusion) under a fixed ratio 1 (FR1) or progressive ratio (PR) schedule of reinforcement at an ambient temperature of 23 ± 1°C. They were then given their daily self-administration session at a raised ambient temperature of 30 ± 1°C. Methamphetamine self-administration was increased at 30°C under both FR1 and PR reinforcement schedules, with the latter effect indicating that heat enhances the motivation to obtain methamphetamine. High temperatures did not alter self-administration of the D1 receptor agonist SKF 82958 in methamphetamine-experienced rats suggesting some specificity in the methamphetamine effect. When rats were given access to drink isotonic saline solution during methamphetamine self-administration sessions they drank much more solution at 30°C than 23°C. However, availability of isotonic saline to drink did not alter the heat-induced facilitation of methamphetamine self-administration (PR schedule) indicating that the heat effect does not simply reflect increased motivation for intravenous fluids. Hyperthermia was evident in rats self-administering methamphetamine at high ambient temperatures and fluid consumption did not prevent this effect. Heat did not affect blood levels of methamphetamine, or its principal metabolite amphetamine indicating that the facilitatory effect of heat did not reflect altered methamphetamine pharmacokinetics. Overall, these results show that high ambient temperatures increase the reinforcing efficacy of methamphetamine and encourage higher levels of drug intake.