Miracle-dz/UniFAR-FTUs huggingface dataset:
Fertility-preserving treatment in complex atypical hyperplasia and early endometrial cancer in young women with oral progestin: Is it effective?

Objective The aim of this study is to assess the effectiveness of oral progestin treatment in women diagnosed with complex atypical hyperplasia (CAH) or grade 1 endometrial cancer (G1EC), who desire to preserve their fertility, as alternative treatment to a hysterectomy. Methods We reviewed the medical records of women younger than 45 years old that had been diagnosed with CAH or G1EC, who expressed a desire to preserve their fertility using alternative treatment at our institution. Women without evidence of myometrial invasion on pelvic magnetic resonance imaging scans were included. The study period was between 2004 and 2014. Endometrial biopsies were taken at follow-up appointments. Results We identified 31 young women with CAH or G1EC. The median age was 33 years old (range, 20 to 41), and the median period of time undertaking the treatment was 5 months (range, 1 to 12). Twenty-three patients (74.2%) achieved complete remission (CR; median time to CR was 3 months; range, 1 to 22), 16 patients (88.9%) with CAH and 7 (53.8%) with G1EC achieved CR. 6 patients (26.1%) who had achieved CR, had recurrence of the disease (median time from CR to recurrence was 12.5 months; range, 4 to 18). Eight patients (25.8%) finally underwent a hysterectomy. Conclusion Oral progestin therapy is an alternative treatment for women with CAH or G1EC who desire fertility preservation. However, more prospective studies are needed for standard progestin regimen. Also, there still remains a risk of disease progression and recurrence. Therefore, close follow-up is important during treatment and after CR. In addition, a hysterectomy is recommended as a definitive treatment after completion of childbearing.
Web Design in E-Commerce: A Theory and Empirical Analysis

In the Internet market, websites are the main interface between online merchants and their customers. Effective website design plays a critical role in attracting and maintaining customers’ interest and in influencing their purchase behavior. Despite the singular significance of website design, little theoretical knowledge is available regarding how web-design elements impact the purchase behavior of online shoppers. By drawing on the theory of planned behavior and interpersonal influence, we develop and empirically test a conceptual model for the process by which web design elements could influence the purchase intention of online customers. This research provides a theoretical framework for the design decisions regarding websites in order to accommodate the salient features of online shopping.
Towards a general independent subspace analysis

The increasingly popular independent component analysis (ICA) may only be applied to data following the generative ICA model in order to guarantee algorithm-independent and theoretically valid results. Subspace ICA models generalize the assumption of component independence to independence between groups of components. They are attractive candidates for dimensionality reduction methods, however are currently limited by the assumption of equal group sizes or less general semi-parametric models. By introducing the concept of irreducible independent subspaces or components, we present a generalization to a parameter-free mixture model. Moreover, we relieve the condition of at-most-one-Gaussian by including previous results on non-Gaussian component analysis. After introducing this general model, we discuss joint block diagonalization with unknown block sizes, on which we base a simple extension of JADE to algorithmically perform the subspace analysis. Simulations confirm the feasibility of the algorithm.
SEX MAY SELL BUT GENDER IDENTITY PREDICTS: AN INVESTIGATION OF COLLEGE STUDENTS’ PROPENSITY TO JOIN ENTREPRENEURSHIP CLUBS

SEX MAY SELL BUT GENDER IDENTITY PREDICTS: AN INVESTIGATION OF COLLEGE STUDENTS’ PROPENSITY TO JOIN ENTREPRENEURSHIP CLUBS by Jerald L. Wallace A rich and diverse stream of research has focused on assessing different outcomes between men and women entrepreneurs. Popular stereotypes maintain that women are neither as interested, or successful as entrepreneurs compared to men. However, most past research has used biological sex as a proxy to measure differences between women and men dichotomously. The problem with this approach is that it is an oversimplified approach to a complex issue. To address this problem, the more recent literature suggests the inclusion of more meaningful variables, such as gender identity, an individual’s concept of their traits both masculine and feminine, to assess perceived differences between women and men in general, and their interest to engage in entrepreneurship in particular. Based on relevant research in entrepreneurship, psychology, gender studies, sociology, vocational behavior, social linguistics, and educational pedagogy, the present study develops and tests a series of hypotheses utilizing variables within the entrepreneurial environment that are gendered in nature and predict entrepreneurial interest. The competitive climate of the entrepreneurial environment influencing men and women considering the field will further elucidate the causal linkages. Specifically, the vii viii influence of gender identity, personality characteristics related to gender, and perceptions of fit into entrepreneurship communities is investigated based on college students’ intent to engage in entrepreneurial clubs and associations at their universities. The results from this study will contribute to the literature on gender and entrepreneurship in areas previous research has not fully considered. The practical contributions of this research are aimed at better identifying past and present barriers to opportunity and promoting educational pedagogy that looks beyond the limitations of sex categorization.
Life Satisfaction Predicts Positive Workplace Outcomes Among Filipino Guidance Counselors

Correspondence concerning this article can be addressed to Niño Jose Mateo, Counseling and Educational Psychology Department, 1602 Br. Andrew Gonzales Hall, College of Education, De La Salle University, 2401 Taft Avenue, Manila. Email: nino.mateo@dlsu.edu. ph One of the primary contributions of literature on positive psychology is providing strong evidence for the link between happiness and success (Lyubomirsky, King, & Diener, 2005). Happy individuals evaluate their life as satisfying, report an overall sense of well-being, and are oriented towards personal growth and goal attainment. The study tested the broaden-and-build theory of positive emotions (Fredrickson, 1998; 2003) in the field of counseling practice. The researchers hypothesized that counselors’ life satisfaction would predict outcomes relevant in practice: counseling self-efficacy, emotional awareness, and flow state. Participants (n = 137) completed measures of counseling self-efficacy, flow state, life satisfaction, and emotional awareness. Age, gender, civil status, and degree earned were identified as covariates and their effects were controlled in the regression analyses. Findings revealed that life satisfaction positively predicted flow state and emotional awareness. Counselors who expressed greater satisfaction with their lives seem to see the counseling experience as rewarding and are more attuned to their emotions. This finding is consistent with the key postulate of broaden-and-build theory on the beneficial consequences of positive affect on psychological resources.
Intentional Personality Change: The Development and Evaluation of a Group Based Program to Increase Conscientiousness

The current thesis contains a series of papers which explored intentional personality change. The first paper explored what aspects of personality people want to change and what are the personality characteristics of those who want to change their personality. This study utilised data gathered during Martin, Oades and Caputi’s (2014a) randomised waitlist controlled trial of their intentional personality change coaching program (Martin, Oades & Caputi, 2014b). The results of the study indicated that the personality domains that people most wanted to change were neuroticism and conscientiousness and the sub-domains (facets) were anxiety, self-discipline, anger/hostility, depression and self-consciousness. Participants in the study were significantly higher in neuroticism and openness than the general population. The second study explored what domains of personality had been changed via the intervention conducted by Martin et al. (2014a) and whether these changes were dependent on those aspects of personality being targeted for change. The findings of the study indicated that participants experienced significant increases in extraversion and conscientiousness and significant decreases in neuroticism over the 10 week coaching program. These changes were maintained three month post-intervention. Targeting of facets within the domain was significantly related to change for the domain of conscientiousness and neuroticism but not for extraversion. The third paper was a review of the literature informing the development of personality change resources, followed by a more specific review exploring personality change resource development for the domain of conscientiousness. The paper argued for the utilisation of change processes which have been found to be effective in psychotherapy to be combined with the limited intentional personality change intervention literature in developing future personality change resources. The paper also argued that the clinical literature could be
Targeted Therapies for Non–Small Cell Lung Cancer: An Evolving Landscape

Over the past decade, a multitude of targeted agents have been explored in the treatment of advanced non–small cell lung cancer (NSCLC). Thus far, two broad classes of agents have been implemented in clinical practice: (a) vascular endothelial growth factor (VEGF)-directed therapies and (b) antagonists of the epidermal growth factor receptor (EGFR). In the former category, the agent bevacizumab (a monoclonal antibody) has shown landmark improvements in survival when added to cytotoxic therapy. Small molecule tyrosine kinase inhibitors (TKI) targeting the VEGF receptor (i.e., sunitinib, sorafenib, and vandetanib) show activity in phase II clinical studies. With respect to EGFR-directed therapies, the TKIs gefitinib and erlotinib have shown significant benefit, and have uncovered valuable information about the biology of lung cancer. Outside of therapies directed specifically at VEGF- and EGFR-mediated signaling, trials evaluating insulin-like growth factor-1 receptor (IGF-IR)-targeting agents, cyclooxygenase-2 (COX-2) inhibitors, c-met inhibitors, irreversible pan-HER inhibitors, mammalian target of rapamycin (mTOR) inhibitors, and histone deacetylase (HDAC) inhibitors are ongoing. Inhibitors of ALK show great promise in patients with the relevant gene translocation. Herein, the clinical development of novel therapies for NSCLC is described, including some discussion of relevant biomarkers and determination of synergy with both cytotoxic therapy and other targeted agents. Mol Cancer Ther; 9(7); 1931–44. ©2010 AACR.
Overdensity of X-Ray Sources in the Field of Two Nearby Clusters of Galaxies: XMM-Newton View of A 194 and A 1060

Two nearby clusters of galaxies, A194 (z =0 .018) and A1060 (z =0 .0114), have been analyzed for their X-ray point-source properties with XMM-Newton EPIC-PN data. A multi-band source detection technique was applied to both of the clusters, resulting in 46 sources from the A194 field and 32 sources from the A1060 field, respectively. The cumulative log(N)–log(S) for a flux limit of FX ≥ 1 × 10 −14 ergcm −2 s −1 was calculated and compared with that of the Lockman Hole. A ∼ 3 σ excess of X-ray sources was found for the cluster regions. Considering the higher fraction observed in optical studies from the clusters, we estimate that the cluster source density is 6-times higher than the blank-field source density, and 15-times higher than the local group. Our X-ray selected sources have luminosity values of 10 39.6 ≤ LX ≤ 10 41.4 ergs −1 , in which X-ray emission from LMXBs, hot halos and starburst galaxies becomes noticeable. The significance of the source-density excess gradually vanishes for sources with LX ≥ 10 40.5 ergs −1 , at which point the source density becomes comparable to that of the blankfield level. Considering this confined low-luminosity range and the X-ray to optical luminosity ratios (LX/LB), the observed overdensity is ascribed to AGN fueling by its infall into cluster environment for LX ≤ 10 40.5 ergs −1 in the X-ray luminosity function. However, the quenching of AGN activity by the deep cluster potential explains why the excess of the source density vanishes for brighter sources.
Persistence of spatial meanings in the conceptualization of causality: at, by, with and about in emotion constructions

Abstract Prepositions encode various causal forces when expressing emotion causality in emotion constructions. This study investigates two pairs of prepositions, the zerodimensional at and by, and the two- or three-dimensional with and about, which show contrasting collocation patterns in emotion constructions. Through a corpus analysis of the Corpus of Contemporary American English, this study claims that there is a strong tendency that zero-dimensional prepositions are used with short-term emotions, whereas two- or three-dimensional prepositions frequently occur with long-term emotions. This study argues that the constraints of distributions of prepositions with emotive adjectives can be accounted for by features of their spatial source meanings in early usages. In the framework of grammaticalization, the constraints of collocation patterns of two pairs of prepositions with emotive adjectives show the phenomenon with respect to the “persistence” of Hopper (1991) in which traces of the source lexemes are retained in the constraints of their distributions. This study is significant in that it suggests a typology of causality based on spatial dimensions of prepositions.
Pseudotyping of Glycoprotein D-Deficient Herpes Simplex Virus Type 1 with Vesicular Stomatitis Virus Glycoprotein G Enables Mutant Virus Attachment and Entry

ABSTRACT The use of herpes simplex virus (HSV) vectors for in vivo gene therapy will require the targeting of vector infection to specific cell types in certain in vivo applications. Because HSV glycoprotein D (gD) imparts a broad host range for viral infection through recognition of ubiquitous host cell receptors, vector targeting will require the manipulation of gD to provide new cell recognition specificities in a manner designed to preserve gD's essential role in virus entry. In this study, we have determined whether an entry-incompetent HSV mutant with deletions of all Us glycoproteins, including gD, can be complemented by a foreign attachment/entry protein with a different receptor-binding specificity, the vesicular stomatitis virus glycoprotein G (VSV-G). The results showed that transiently expressed VSV-G was incorporated into gD-deficient HSV envelopes and that the resulting pseudotyped virus formed plaques on gD-expressing VD60 cells, albeit at a 50-fold-reduced level compared to that of wild-type gD. This reduction may be related to differences in the entry pathways used by VSV and HSV or to the observed lower rate of incorporation of VSV-G into virus envelopes than that of gD. The rate of VSV-G incorporation was greatly improved by using recombinant molecules in which the transmembrane domain of HSV glycoprotein B or D was substituted for that of VSV-G, but these recombinant molecules failed to promote virus entry. These results show that foreign glycoproteins can be incorporated into the HSV envelope during replication and that gD can be dispensed with on the condition that a suitable attachment/entry function is provided.
Significance of KRAS, NRAS, BRAF and PIK3CA mutations in metastatic colorectal cancer patients receiving Bevacizumab: a single institution experience

Background. KRAS mutation is an important predictive and prognostic factor for patients receiving anti-EGFR therapy. An expanded KRAS, NRAS, BRAF, PIK3CA mutation analysis provides additional prognostic information, but its role in predicting bevacizumab efficacy is unclear. The aim of our study was to evaluate the incidence of KRAS, NRAS, BRAF and PIK3CA mutations in metastatic colorectal cancer patients receiving first line oxaliplatin based chemotherapy with or without bevacizumab and to evaluate their prognostic and predictive significance. Methods. 55 patients with the first-time diagnosed CRC receiving FOLFOX ± bevacizumab were involved in the study. Tumour blocks were tested for KRAS mutations in exons 2, 3 and 4, NRAS mutations in exons 2, 3 and 4, BRAF mutation in exon 15 and PIK3CA mutations in exons 9 and 20. The association between mutations and clinico-pathological factors, treatment outcomes and survival was analyzed. Results. KRAS mutations were detected in 67.3% of the patients, BRAF in 1.8%, PIK3CA in 5.5% and there were no NRAS mutations. A significant association between the high CA 19–9 level and KRAS mutation was detected (mean CA 19–9 levels were 276 and 87 kIU/l, respectively, p = 0.019). There was a significantly higher response rate in the KRAS, NRAS, BRAF and PIK3CA wild type cohort receiving bevacizumab compared to any gene mutant type (100 and 60%, respectively, p = 0.030). The univariate Cox regression analysis did not confirm KRAS and other tested mutations as prognostic factors for PFS or OS. Conclusions. Our study revealed higher KRAS and lower NRAS, BRAF and PIK3CA mutation rates in the Lithuanian population than those reported in the literature. KRAS mutation was associated with the high CA 19–9 level and mucinous histology type, but did not show any predictive or prognostic significance. The expanded KRAS, NRAS, BRAF and PIK3CA mutation analysis provided additional significant predictive information.
Homozygous/Compound Heterozygous Triadin Mutations Associated With Autosomal-Recessive Long-QT Syndrome and Pediatric Sudden Cardiac Arrest: Elucidation of the Triadin Knockout Syndrome

Background— Long-QT syndrome (LQTS) may result in syncope, seizures, or sudden cardiac arrest. Although 16 LQTS-susceptibility genes have been discovered, 20% to 25% of LQTS remains genetically elusive. Methods and Results— We performed whole-exome sequencing child–parent trio analysis followed by recessive and sporadic inheritance modeling and disease-network candidate analysis gene ranking to identify a novel underlying genetic mechanism for LQTS. Subsequent mutational analysis of the candidate gene was performed with polymerase chain reaction, denaturing high-performance liquid chromatography, and DNA sequencing on a cohort of 33 additional unrelated patients with genetically elusive LQTS. After whole-exome sequencing and variant filtration, a homozygous p.D18fs*13 TRDN-encoded triadin frameshift mutation was discovered in a 10-year-old female patient with LQTS with a QTc of 500 milliseconds who experienced recurrent exertion-induced syncope/cardiac arrest beginning at 1 year of age. Subsequent mutational analysis of TRDN revealed either homozygous or compound heterozygous frameshift mutations in 4 of 33 unrelated cases of LQTS (12%). All 5 TRDN-null patients displayed extensive T-wave inversions in precordial leads V1 through V4, with either persistent or transient QT prolongation and severe disease expression of exercise-induced cardiac arrest in early childhood (⩽3 years of age) and required aggressive therapy. The overall yield of TRDN mutations was significantly greater in patients ⩽10 years of age (5 of 10, 50%) compared with older patients (0 of 24, 0%; P=0.0009). Conclusions— We identified TRDN as a novel underlying genetic basis for recessively inherited LQTS. All TRDN-null patients had strikingly similar phenotypes. Given the recurrent nature of potential lethal arrhythmias, patients fitting this phenotypic profile should undergo cardiac TRDN genetic testing.
Remediation of Soils and Ground Water Contaminated by Aromatic and Chlorinated Hydrocarbons and Metals

The contents of this paper reflect the views of the authors, who are responsible for the facts and the accuracy of the data presented herein, and do not necessarily reflect the official views or policies of the Federal Highway Administration and the Indiana Department of Transportation, nor do the contents constitute a standard, specification, or regulation. Many of the Indiana Department of Transportation (INDOT) sites are contaminated with aromatic hydrocarbons and chlorinated solvents; these contaminants often occur in the form of light non-aqueous phase liquids (LNAPLs) or dense non-aqueous phase liquids (DNAPLs). Considerable effort has recently been focused on developing in-situ technologies for removing or destroying NAPL source zones, and several potentially viable methods have emerged, including in-situ chemical oxidation (ISCO). ISCO has become an attractive remediation option to managers at many contaminated sites. The three oxidants that are most often applied in-situ are hydrogen peroxide (H 2 O 2) with iron catalysts, potassium permanganate (KMnO 4), and ozone (O 3). While each oxidant system has been field demonstrated to be effective in some instances, a clear understanding of these processes is important to the successful implementation of the technology. The primary goal of the laboratory experiments is to evaluate strategies for improving the effectiveness and efficiency of the oxidants as applied to aggressive remediation of source zones containing residual saturations of NAPLs, particularly as applied at INDOT sites. Several novel approaches have been taken to reach the goals of the study. The first approach enhances the application of Fenton's reagent in soil slurry systems, resulting in a better understanding of the magnitude of non-specific oxidant losses relative to consumption by the target compounds. The second approach explores minimizing non-specific losses of the oxidant by introducing the oxidant (KMnO 4) in an encapsulated form. Finally, solubility enhancers are examined to enhance the aqueous NAPL concentrations. Significant enhancements in NAPL aqueous concentration will result in corresponding enhancements of the observed oxidation rate. Based on input from INDOT staff, selected sites will be assessed for amenability to remediation via in-situ oxidation. Efforts will be made to choose sites that are representative of a broad range of INDOT needs. Assessment required travel by senior personnel to specific sites to evaluate the nature and extent of contamination. Site visits were also be made by research assistants to collect soil samples for laboratory experiments. Introduction Many of the Indiana Department of Transportation (INDOT) sites are …