Miracle-dz/UniFAR-FTUs huggingface dataset:
Sentence Reading and Writing for Second Language Vocabulary Acquisition

This study compares the relative effectiveness of reading and writing sentences for the incidental acquisition of new vocabulary in a second language. It also examines if recall varies according to the concreteness of target words. Participants were 203 French-speaking intermediate and advanced English as second language (ESL) learners, tested for incidental acquisition of 16 rare concrete, or abstract L2 words. Immediate and delayed cued recall was used to assess acquisition. Results from immediate recall show superior recall for writing tasks over reading tasks, and for concrete words over abstract words. However, delayed recall scores suggest that this superiority disappears over time.
Sediment transport‐storage relations for degrading, gravel bed channels

In a drainage network, sediment is transferred through a series of channel/valley segments (natural sediment storage reservoirs) that are distinguished from their neighbors by their particular capacity to store and transport sediment. We propose that the sediment transport capacity of each reservoir is a unique positive function of storage volume, which influences sediment mobility and availability through variations in bed surface texture, channel gradient, and availability of valley floor sediments for erosion. Examinations of the form of transport‐storage relations of degrading alluvial reservoirs using published field studies, flume experiments, and simulations support a conceptual model that includes two phases. In phase I, filled channels respond to variations in supply primarily by changes in stored sediment volume, with little change in transport rate. In phase II, channel mobility is responsive to supply through armoring and form roughness. Although these phases could represent idealized transport‐limited (phase 1) or supply‐limited (phase II) states, we propose that every alluvial reservoir responds to changes in sediment inputs by changing both storage and transport rate, the propensity for either depending on reservoir characteristics and the sediment exchange processes in the channel. Transport‐storage relations for phase II are approximately linear, but examination of numerical simulations and flume experiments indicates that armoring imparts positive curvature. Simulations of degradation of an alluvial reservoir with channel and valley floor surfaces indicate that interactions between channel lowering and lateral erosion are critical in the manifestation of a transport‐storage relation. Better knowledge of transport–storage relations could lead to improved sediment‐routing models for drainage basins wherein component sediment reservoirs dynamically adjust to varying sediment loads.
Central and Peripheral Mechanisms of T-Lymphocyte Activation and Vascular Inflammation Produced by Angiotensin II–Induced Hypertension

Rationale: We have previously found that T lymphocytes are essential for development of angiotensin II–induced hypertension; however, the mechanisms responsible for T-cell activation in hypertension remain undefined. Objective: We sought to study the roles of the CNS and pressure elevation in T-cell activation and vascular inflammation caused by angiotensin II. Methods and Results: To prevent the central actions of angiotensin II, we created anteroventral third cerebral ventricle (AV3V) lesions in mice. The elevation in blood pressure in response to angiotensin II was virtually eliminated by AV3V lesions, as was activation of circulating T cells and the vascular infiltration of leukocytes. In contrast, AV3V lesioning did not prevent the hypertension and T-cell activation caused by the peripheral acting agonist norepinephrine. To determine whether T-cell activation and vascular inflammation are attributable to central influences or are mediated by blood pressure elevation, we administered hydralazine (250 mg/L) in the drinking water. Hydralazine prevented the hypertension and abrogated the increase in circulating activated T cells and vascular infiltration of leukocytes caused by angiotensin II. Conclusions: We conclude that the central and pressor effects of angiotensin II are critical for T-cell activation and development of vascular inflammation. These findings also support a feed-forward mechanism in which modest degrees of blood pressure elevation lead to T-cell activation, which in turn promotes inflammation and further raises blood pressure, leading to severe hypertension.
Pocket switched networks and human mobility in conference environments

Pocket Switched Networks (PSN) make use of both human mobility and local/global connectivity in order to transfer data between mobile users' devices. This falls under the Delay Tolerant Networking (DTN) space, focusing on the use of opportunistic networking. One key problem in PSN is in designing forwarding algorithms which cope with human mobility patterns. We present an experiment measuring forty-one humans' mobility at the Infocom 2005 conference. The results of this experiment are similar to our previous experiments in corporate and academic working environments, in exhibiting a power-law distrbution for the time between node contacts. We then discuss the implications of these results on the design of forwarding algorithms for PSN.
Conditional ROCK Activation In vivo Induces Tumor Cell Dissemination and Angiogenesis

Progression of tumors to invasive and metastatic forms requires that tumor cells undergo dramatic morphologic changes, a process regulated by Rho GTPases. Elevated expression of RhoA and RhoC, as well as the Rho effector proteins ROCK I and ROCK II, are commonly observed in human cancers and are often associated with more invasive and metastatic phenotypes. To examine how ROCK contributes to the progression of solid tumors, we established a conditionally activated form of ROCK II by fusing the kinase domain to the estrogen receptor hormone-binding domain (ROCK:ER). ROCK:ER-expressing colon carcinoma cells grown as tumors in immunocompromised nude mice organized into discrete clusters surrounding blood vessels. However, ROCK:ER activation resulted in the aggressive dissemination of tumor cells into the surrounding stroma, indicating that increased ROCK signaling is sufficient to promote invasion from solid tumors. In addition, tumors in which ROCK:ER was activated were more highly vascularized, indicating that ROCK contributes to tumor angiogenesis. ROCK:ER activation resulted in changes to epithelial morphology and organization that facilitated motility in vitro, likely by inducing the redistribution of proteins such as ezrin, as well as adherens junction and extracellular matrix-binding proteins. These results suggest that ROCK inhibitors would be useful antimetastatic and antiangiogenic chemotherapeutic agents in tumors associated with elevated RhoA, RhoC, ROCK I, or ROCK II expression.
Good Lamps Are the Best Police

Darkness can conceal identity and encourage moral transgressions; it may also induce a psychological feeling of illusory anonymity that disinhibits dishonest and self-interested behavior regardless of actual anonymity. Three experiments provided empirical evidence supporting this prediction. In Experiment 1, participants in a room with slightly dimmed lighting cheated more and thus earned more undeserved money than those in a well-lit room. In Experiment 2, participants wearing sunglasses behaved more selfishly than those wearing clear glasses. Finally, in Experiment 3, an illusory sense of anonymity mediated the relationship between darkness and self-interested behaviors. Across all three experiments, darkness had no bearing on actual anonymity, yet it still increased morally questionable behaviors. We suggest that the experience of darkness, even when subtle, may induce a sense of anonymity that is not proportionate to actual anonymity in a given situation.
Exploiting stoichiometric redundancies for computational efficiency and network reduction

Abstract Analysis of metabolic networks typically begins with construction of the stoichiometry matrix, which characterizes the network topology. This matrix provides, via the balance equation, a description of the potential steady-state flow distribution. This paper begins with the observation that the balance equation depends only on the structure of linear redundancies in the network, and so can be stated in a succinct manner, leading to computational efficiencies in steady-state analysis. This alternative description of steady-state behaviour is then used to provide a novel method for network reduction, which complements existing algorithms for describing intracellular networks in terms of input-output macro-reactions (to facilitate bioprocess optimization and control). Finally, it is demonstrated that this novel reduction method can be used to address elementary mode analysis of large networks: the modes supported by a reduced network can capture the input-output modes of a metabolic module with significantly reduced computational effort.
Anti-spasticity agents for multiple sclerosis.

BACKGROUND Spasticity is a common problem in MS patients causing pain, spasms, loss of function and difficulties in nursing care. A variety of oral and parenteral medications are available. OBJECTIVES To assess the absolute and comparative efficacy and tolerability of anti-spasticity agents in multiple sclerosis (MS) patients. SEARCH STRATEGY We searched the Cochrane MS Group trials register (June 2003), the Cochrane Central Register of Controlled Trials (CENTRAL) (Issue 2, 2003), MEDLINE (January 1966 to June 2003), EMBASE (January 1988 to June 2003), bibliographies of relevant articles, personal communication, manual searches of relevant journals and information from drug companies. SELECTION CRITERIA Double-blind, randomised controlled trials (either placebo-controlled or comparative studies) of at least seven days duration. DATA COLLECTION AND ANALYSIS Two independent reviewers extracted data and the findings of the trials were summarised. Missing data were collected by correspondence with principal investigators. A meta-analysis was not performed due to the inadequacy of outcome measures and methodological problems with the studies reviewed. MAIN RESULTS Twenty-six placebo-controlled studies (using baclofen, dantrolene, tizanidine, botulinum toxin, vigabatrin, prazepam, threonine and cannabinoids) and thirteen comparative studies met the selection criteria and were included in this review. Only fifteen of these studies used the Ashworth scale, of which only three of the eight placebo-controlled trials and none of the seven comparative studies showed a statistically significant difference between test drugs. Spasms, other symptoms and overall impressions were only assessed using unvalidated scores and results of functional assessments were inconclusive. REVIEWER'S CONCLUSIONS The absolute and comparative efficacy and tolerability of anti-spasticity agents in multiple sclerosis is poorly documented and no recommendations can be made to guide prescribing. The rationale for treating features of the upper motor neurone syndrome must be better understood and sensitive, validated spasticity measures need to be developed.
Measuring individuals' response quality in self-administered psychological tests: an introduction to Gendre's functional method

The functional method is a new test theory using a new scoring method that assumes complexity in test structure, and thus takes into account every correlation between factors and items. The main specificity of the functional method is to model test scores by multiple regression instead of estimating them by using simplistic sums of points. In order to proceed, the functional method requires the creation of hyperspherical measurement space, in which item responses are expressed by their correlation with orthogonal factors. This method has three main qualities. First, measures are expressed in the absolute metric of correlations; therefore, items, scales and persons are expressed in the same measurement space using the same single metric. Second, factors are systematically orthogonal and without errors, which is optimal in order to predict other outcomes. Such predictions can be performed to estimate how one would answer to other tests, or even to model one's response strategy if it was perfectly coherent. Third, the functional method provides measures of individuals' response validity (i.e., control indices). Herein, we propose a standard procedure in order to identify whether test results are interpretable and to exclude invalid results caused by various response biases based on control indices.
Research and applications: Supervised machine learning and active learning in classification of radiology reports

OBJECTIVE This paper presents an automated system for classifying the results of imaging examinations (CT, MRI, positron emission tomography) into reportable and non-reportable cancer cases. This system is part of an industrial-strength processing pipeline built to extract content from radiology reports for use in the Victorian Cancer Registry. MATERIALS AND METHODS In addition to traditional supervised learning methods such as conditional random fields and support vector machines, active learning (AL) approaches were investigated to optimize training production and further improve classification performance. The project involved two pilot sites in Victoria, Australia (Lake Imaging (Ballarat) and Peter MacCallum Cancer Centre (Melbourne)) and, in collaboration with the NSW Central Registry, one pilot site at Westmead Hospital (Sydney). RESULTS The reportability classifier performance achieved 98.25% sensitivity and 96.14% specificity on the cancer registry's held-out test set. Up to 92% of training data needed for supervised machine learning can be saved by AL. DISCUSSION AL is a promising method for optimizing the supervised training production used in classification of radiology reports. When an AL strategy is applied during the data selection process, the cost of manual classification can be reduced significantly. CONCLUSIONS The most important practical application of the reportability classifier is that it can dramatically reduce human effort in identifying relevant reports from the large imaging pool for further investigation of cancer. The classifier is built on a large real-world dataset and can achieve high performance in filtering relevant reports to support cancer registries.
Use of porta-cath in cancer patients : a single-center experience

Introduction: Central venous catheters play an important role in the management of cancer patients. Different types of devices are associated with different patterns of complications. We report on the pattern of use and rate of complications of port-a-caths in patients diagnosed with malignant cancer at a single institution. Methodology: The data were collected retrospectively from patients who received the treatment for solid tumors or lymphoma through a porta-cath at the Sultan Qaboos University Hospital (SQUH) between January 2007 and February 2013. Results: A total of 117 port-a-caths were inserted in 106 patients. The majority (86; 73.5%) were implanted by an interventional radiologist, and the right internal jugular vein was accessed in 79 (67.5%) patients. Mean catheter indwelling time was 354 (range 3–1,876) days for all patients, 252 (3–1,876) and 389 days (13–1,139) for patients with and without complications, respectively. Thirty (25.6%) port-a-caths were removed prematurely, mainly due to infectious complications, while 17 (14.5%) were removed after completion of treatment. Staphylococcus aureus was the most frequently isolated organism, found in 8 (6.8%) patients. Underlying diagnosis (p < 0.001), chemotherapy regimen (p < 0.001), sensitivity to antibiotics (p = 0.01), and any complication (p < 0.001) were significant factors affecting the duration of port-a-cath use. None of these factors were significant on multivariate cox regression analysis. Conclusions: The mean duration of port-a-cath use was almost one year. Infection was the most common complication leading to premature removal, followed by port thrombosis.
Characterization of the Rat INSL3 Receptor

Abstract: Human LGR8, initially discovered as a low‐affinity relaxin receptor, has now been characterized as the INSL3 receptor. To investigate LGR8 function in the rat, an LGR8 ortholog was identified in the rat genome, and the full‐length sequence was cloned and expressed. Rat LGR8 bound INSL3 with high affinity, clearly demonstrating that it is the rat INSL3 receptor. Interestingly, native rat relaxin did not activate rat LGR8, indicating that relaxin is not an endogenous ligand for rat LGR8. LGR8 mRNA expression was demonstrated in the gubernaculum at the time of testis descent and in the testis associated with germ cells.
Use of Distance Education by Religions of the World to Train, Edify, and Educate Adherents

Islamic, Hindu, Buddhist, Baha'i, Jewish, and Christian organizations are all experimenting with distance education for various reasons and to different extents, due to religious, economic, and political factors. Religious institutions worldwide are not only turning to the World Wide Web (WWW) to place information concerning religious beliefs and provide virtual services for their constituents but are also getting more involved in formally educating their members at a distance. This paper will document some of these educational efforts and the reasons behind the expanding use of distance education by several of the major religious institutions for training, edifying, and educating their religious adherents.
Strategic Behavior, Financing, and Stock Returns

In this paper I analyze how debt structure and the strategic interaction between shareholders and creditors in the event of default affect expected stock returns. By endogenizing shareholders' decision to default, the model generates new predictions linking firm characteristics to expected stock returns through an intuitive economic mechanism. In particular, the model predicts that expected stock returns are higher for firms that face high debt renegotiation difficulties, and that have a large fraction of secured or convertible debt. Expected stock returns are lower for firms whose shareholders maintain strong bargaining power, and for firms subject to high liquidation costs. Using a large sample of publicly traded US firms between 1985 and 2005, I present new evidence on the link between debt structure, renegotiation frictions, and stock returns, which is supportive of the model's predictions.
Discourse as Data: A Guide for Analysis

This workbook will be invaluable for students across the social sciences who need to learn how to analyze discourse. Using a step-by-step approach, students are introduced to the principal range of methods for analyzing different types of text, taken through key analytic concepts, offered specimen analyses and given the opportunity to try out analytic concepts on new data. Discourse as Data is organized around eight chapters, six of which are related to the domains covered in the Reader, and top and tailed by two chapters which set up common methodological issues in discourse research relevant to all approaches (such as transcription and the application and the critical evaluation of discourse research). Though the text will be a perfect companion to the simultaneously published Reader, its broad coverage, combined with didactic, practical guidance should make this important reading for any student or researcher wishing to learn more about discourse analysis. This book will be ideal as a teaching tool, and an invaluable aid on discourse analysis courses, which have a practical content, most notably within the fields of psychology, cultural and media studies, sociology and linguistics.
Quantum magnetic deflagration in Mn12 acetate

We report controlled ignition of magnetization reversal avalanches by surface acoustic waves in a single crystal of ${\mathrm{Mn}}_{12}$ acetate. Our data show that the speed of the avalanche exhibits maxima on the magnetic field at the tunneling resonances of ${\mathrm{Mn}}_{12}$. Combined with the evidence of magnetic deflagration in ${\mathrm{Mn}}_{12}$ acetate [Y. Suzuki et al., Phys. Rev. Lett. 95, 147201 (2005)], this suggests a novel physical phenomenon: deflagration assisted by quantum tunneling.
Analysis of Heat Pump Cycle Using CO2/DME Mixture Refrigerant

In this study, the performance analysis of heat pump cycle using carbon dioxide (CO2) and dimethyl ether (DME) zeotropic mixture has been carried out by cycle calculation in order to clarify the characteristics and coefficient of performance (COP) of CO2/DME heat pump cycle. The calculation conditions were established as a hot-water supply system and the calculations were conducted by considering the heat transfer between the refrigerant and heat source/sink water. The heat pump cycle is formed around the critical point for high CO2 concentration mixtures and it is formed under the critical point for low CO2 concentration mixtures. The COP has the maximum at a certain pressure for each mixture and the COPs of the mixture and pure DME are higher than that of pure CO2. Operating pressure and refrigerant mass flow rate decreases with increase of DME concentration. The effects of concentration on characteristics of the cycle have also been discussed.
Phosphorylation of Threonine-19 of PSD-95 by GSK-3β is Required for PSD-95 Mobilization and Long-Term Depression

Activity of glycogen synthase kinase-3β (GSK-3β) is required for long-term depression (LTD) via molecular mechanisms that are incompletely understood. Here, we report that PSD-95, a major scaffold protein of the postsynaptic density (PSD) that promotes synaptic strength, is phosphorylated on threonine-19 (T19) by GSK-3β. In cultured rat hippocampal neurons, phosphorylation of T19 increases rapidly with chemical LTD and is attenuated by pharmacologic or genetic suppression of GSK-3β. In organotypic rat hippocampal slices, we find that a nonphosphorylatable PSD-95 mutant (T19A) tagged with photoactivatable green fluorescent protein (PAGFP) shows enhanced stability in dendritic spines versus wild-type PSD-95, whereas the phosphomimetic mutant (PSD-95-T19D) is more readily dispersed. Further, overexpression of PSD-95-T19A, but not WT-PSD-95, impairs AMPA receptor internalization and the induction of LTD. These data indicate that phosphorylation on T19 by GSK-3β destabilizes PSD-95 within the PSD and is a critical step for AMPA receptor mobilization and LTD.
Neurofibrillary Degeneration in Progressive Supranuclear Palsy and Corticobasal Degeneration

Abstract : Pathological tau prroteins that constitute the basic matrix of neuronal inclusions observed in numerous neurodegenerative disorders are disease specific. This is mainly the consequence of the aggregation of specific sets of tau isoforms according to the diseases, i.e., six isoforms in Alzheimer's disease (AD) and exclusively the three tau isoforms lacking the corresponding sequence of exon 10 (E10‐) in Pick's disease (PiD). By using antibodies specific to the different tau isoforms and one‐ and two‐dimensional gel electrophoresis followed by western blots, we demonstrate herein a third group of neurodegenerative disorders characterized by intraneuronal inclusions exclusively constituted of tau isoforms containing the sequence corresponding to exon 10, progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD). Together, tau isoforms with exon 10 clearly differentiate three groups of neurodegenerative diseases : AD, PiD, and PSP/CBD. For each group, the neuropathological nd clinical phenotypes are most likely related to specifric sets of tau isoforms expressed by the vulnerable neuronal populations. The recently described mutations of the tau gene responsible for familial frontotemporal dementias also support this hypothesis.
Emotional intelligence and occupational stress

ii ACKNOWLEDGEMENTS.v DECLARATION. vi TABLE OF CONTENTS . vii LIST OF TABLES . xiv LIST OF FIGURES . xvii CHAPTER 1: INTRODUCTION.1 1.1 Preamble to the Current Study. 1 1.2 Chapter Synopsis. 3 CHAPTER 2: OCCUPATIONAL STRESS.5 2.