Miracle-dz/UniFAR-FTUs huggingface dataset:
Knowledge, Attitude, and Prevention Practices towards Common Zoonotic Diseases in and around Bahir Dar City, North Western Ethiopia

The problem of zoonoses diseases is a global public and veterinary health concern. Globally coordinated and well-established research efforts are essential to successfully fighting and reducing the health burden of zoonoses. In our study area, the interplay of intense livestock animals, agricultural activities, and poor health services characterized the high risks of zoonotic diseases. Thus, people suffer from easily preventable diseases with hygiene and good-quality food. The main objectives of this study were to: (i) evaluate the knowledge, attitude, and prevention practices of people handling farm animals and their products toward common zoonotic diseases; and (ii) estimate the associated risk factors influencing their knowledge, attitude, and prevention practices. A questionnaire-based cross-sectional study was conducted from December 2021 to August 2022. A simple random sampling technique was followed to select respondents. Multivariable logistic regression model analysis was conducted using STATA version 14. The overall level of knowledge, attitude, and prevention practice for the major zoonotic disease was 52.5%, 68.6%, and 39.4%, respectively. Rabies, tuberculosis, taeniasis, anthrax, and brucellosis were the major zoonotic diseases selected by respondents in the study areas. The age of respondents, training status, educational status, and farm location were significantly (P <0.05) associated with the level of knowledge and prevention practice against zoonotic diseases. This study revealed that the level of knowledge, attitude, and prevention practices for major zoonotic diseases in Bahir Dar City were relatively poor. Therefore, a concerted effort among various government and nongovernment stakeholders, including veterinarians, public health officials, and environmental experts, is needed to create and raise awareness among livestock producers about the transmission and control methods and the economic and public health importance of zoonotic diseases.
Gene Conservation and Loss in themutS-rpoS Genomic Region of PathogenicEscherichia coli

ABSTRACT The extent and nature of DNA polymorphism in themutS-rpoS region of the Escherichia coli genome were assessed in 21 strains of enteropathogenic E. coli(EPEC) and enterohemorrhagic E. coli (EHEC) and in 6 strains originally isolated from natural populations. The intervening region between mutS and rpoS was amplified by long-range PCR, and the resulting amplicons varied substantially in length (7.8 to 14.2 kb) among pathogenic groups. Restriction maps based on five enzymes and sequence analysis showed that strains of the EPEC 1, EPEC 2, and EHEC 2 groups have a long mutS-rpoS region composed of a ∼6.0-kb DNA segment found in strain K-12 and a novel DNA segment (∼2.9 kb) located at the 3′ end of rpoS. The novel segment contains three genes (yclC, pad1, and slyA) that occur in E. coli O157:H7 and related strains but are not found in K-12 or members of the ECOR group A. Phylogenetic analysis of the common sequences indicates that the long intergenic region is ancestral and at least two separate deletion events gave rise to the shorter regions characteristic of the E. coli O157:H7 and K-12 lineages.
Coupling of proadipocyte growth arrest and differentiation. I. Induction by heparinized medium containing human plasma

The differentiation of proadipocytes in vitro typically required prolonged culture of cells as a high density in high concentrations of serum and added hormones. With such culture conditions it is difficult to design experiments to determine the mechanisms that control the differentiation process. We now describe the rapid and parasynchronous growth arrest and differentiation of low density murine proadipocytes in heparinized medium containing only human plasma. When low density cells are cultured under these conditions, growth arrest at a distinct state in the G1 phase of the cell cycle occurs within 2 d and the differentiation of 80-100% of the cell population occurs within 4 d thereafter. The factors in human plasma which promote growth arrest and differentiation are heat labile and can be separated by barium adsorption. In the following paper we have used these methods to show that there are five separate phases which regulate the coupling of proadipocyte growth arrest and differentiation. The data reported in this paper establish that: (a) high cell density and extensive cell-to- cell contact are not required for adipocyte differentiation, (b) prolonged culture is not required for adipocyte differentiation, and (c) high concentrations of serum and/or added hormones are not required for adipocyte differentiation.
Evaluation of ovarian cancer biomarkers HE4 and CA-125 in women presenting with a suspicious cystic ovarian mass

Objective Women presenting with a large or complex ovarian cyst are referred to extensive surgical staging to ensure the correct diagnosis and treatment of a possible epithelial ovarian cancer. We hypothesized that measurement of the biomarkers HE4 and CA-125 preoperatively would improve the assignment of these patients to the correct level of care. Methods Patients diagnosed with a cystic ovarian mass and scheduled for an operation at our center of excellence for ovarian cancer surgery from 2001 to 2010 were prospectively included (n=394) and plasma was collected consecutively. Cut-off for HE4 was calculated at 75% specificity (85 pM and 71.8 pM for post and premenopausal women). For CA-125, 35 U/mL cut-off was used. The study population included women with malignant (n=114), borderline (n=45), and benign (n=215) ovarian tumors. Results Receiver operator characteristic (ROC) area under the curve (AUC) in the benign versus malignant cohorts was 86.8% for CA-125 and 84.4% for HE4. Negative predictive value was 91.7% when at least one of the biomarkers was positive, with only early stage epithelial ovarian cancer showing false negative results. Sensitivity at set specificity (75%) was 87% for risk of ovarian malignancy algorithm (ROMA) in the postmenopausal cohort (cut-off point, 26.0%) and 81% in the premenopausal cohort (cut-off point, 17.3%). ROC AUC in the benign versus stage I epithelial ovarian cancer was only 72% for HE4 and 76% for CA-125. Conclusion In our study, population HE4 did not outperform CA-125. Based on our data a prospective trial with patients already diagnosed with an ovarian cyst may be conducted.
Genetic Diversity of Trypanosomes Infesting Cattle from Savannah District in North of Côte d’Ivoire Using Conserved Genomic Signatures: rRNA, ITS1 and gGAPDH

The potential danger to livestock from African animal trypanosomiasis is well known. However, the trypanosome species circulating in cattle and their genetics are poorly understood. After different alignments according to three regions (ITS1, gGAPDH and rRNA gene) of the trypanosome genome, phylogenetic analyses were used to show the genetic diversity of the different species that were circulating in the cattle in three regions (Bagoue, Poro and Tchologo) of Côte d’Ivoire. These analyses were performed by alignment of ITS1; by alignment of partial 18S, ITS1, 5.8S, ITS2 and partial 28S rRNA genes; and by alignment of gGAPDH gene with sequences of Trypanosomes found in GenBank. Three species were identified (T. vivax, T. theileri and T. congolense) in the cattle in the three northern regions of Côte d’Ivoire. T. vivax and T. theileri were the most abundant species in the present study. Contrary to the other primers used in this study, the ITS1 primers were not able to amplify T. theileri. We observed mixed infections between T. theileri and the other two species identified (T. vivax and T. congolense). As far as primers are concerned, in some cases, rRNA was able to identify the same species of trypanosomes that the ITS1 and gGAPDH primers were able to identify. Two main distinct groups of T. theileri complex were identified. The T. congolense and T. vivax strains were close to African strains, such as those from Kenya, Nigeria and Cameroon, unlike the T. theileri strain. Three trypanosome species (T. vivax, T. theileri and T. congolense) circulate in cattle in the Savannah district of Côte d’Ivoire. The genetic diversity of the trypanosome species encountered in this study cannot be classified as intraspecies according to geographical area and breed of cattle they infect.
Behavioral Corporate Finance : A Survey

Research in behavioral corporate finance takes two distinct approaches. The first emphasizes that investors are less than fully rational. It views managerial financing and investment decisions as rational responses to securities market mispricing. The second approach emphasizes that managers are less than fully rational. It studies the effect of nonstandard preferences and judgmental biases on managerial decisions. This survey reviews the theory, empirical challenges, and current evidence pertaining to each approach. Overall, the behavioral approaches help to explain a number of important financing and investment patterns. The survey closes with a list of open questions. ∗ This article will appear in the Handbook in Corporate Finance: Empirical Corporate Finance, which is edited by Espen Eckbo. The authors are grateful to Heitor Almeida, Nick Barberis, Zahi Ben-David, Espen Eckbo, Xavier Gabaix, Dirk Hackbarth, Dirk Jenter, Augustin Landier, Alexander Ljungqvist, Ulrike Malmendier, Jay Ritter, David Robinson, Hersh Shefrin, Andrei Shleifer, Meir Statman, Theo Vermaelen, Ivo Welch, and Jeffrey Zweibel for helpful comments. Baker and Ruback gratefully acknowledge financial support from the Division of Research of the Harvard Business School.
Additive effects of tamoxifen and the farnesyl transferase inhibitor FTI‐277 on inhibition of MCF‐7 breast cancer cell‐cycle progression

The efficacy of tamoxifen in the hormonal therapy of breast cancer is well established, but therapeutic resistance is inevitable. FTIs are a new class of anticancer drugs that are in phase III clinical evaluation. Since the mechanisms of action of these 2 classes of drugs are different, we tested the combination of tamoxifen and FTI‐277 on inhibiting proliferation of hormone‐dependent MCF‐7 human breast cancer cells. An additive effect on cell proliferation was demonstrated, accompanied by an additive G0/G1 arrest. The major effect of the combination of the 2 drugs was to maintain p21waf/cip1 at an intermediate level, higher than that observed in the presence of tamoxifen alone. This was associated with an additive effect on inactivation of cyclin E–Cdk2 complexes and decreased phosphorylation of pRb and p130 pocket proteins. These effects were accompanied by increased association of 2 CDIs, p27kip1 and p21waf/cip1, with cyclin E–Cdk2 complexes. These data demonstrate that the additive effect is likely predominantly due to the recruitment of p27kip1 and, to a lesser extent, p21waf/cip1 into the cyclin E–Cdk2 complexes. Together, these results suggest that the combination of FTI and tamoxifen may increase the antitumor effect of either drug alone in breast cancer. © 2003 Wiley‐Liss, Inc.
SEA-LEVEL RISE AND SETTLEMENT AT EK WAY NAL: CORING THE PAST

Excavations in the spring and summer of 2022 were carried out at the underwater ancient Maya salt work of Ek Way Nal in Punta Ycacos Lagoon, Paynes Creek National Park, Belize. Ek Way Nal provided salt to the ancient Maya during the Late and Terminal Classic periods (600-900 C.E.). In additional to excavations in buildings at the site, a 1 X 2 m unit was excavated to extract a sediment column for examining the relationship between the ancient Maya settlement at Ek Way Nal and sea-level rise. In this article, the excavations, extraction of the sediment column, and processing it for laboratory analyses are described. Field observations are discussed. Fine red mangrove root (Rhizophora mangle) and charcoal samples were extracted from the sediment column for radiocarbon dating. The results from the datum core excavation indicate that sea-level rise occurred before, during, and after the ancient Maya occupation at Ek Way Nal.
Trends in Educational Technology through the Lens of the Highly Cited Articles Published in the Journal of Educational Technology and Society

The advent of the Internet, World-Wide Web and more recently, advanced technologies such as mobile, sensor and location technologies have changed the way people interact with each other, their lifestyle and almost every other aspect of life. Educational sector is not immune from such effects even if the rate of change is far slower than many other sectors. Researchers have been continuously exploring new ways of using technologies in education and the field is continuously progressing. This paper looks at this progress by analyzing the highly cited articles published in the Journal of Educational Technology and Society, in order to identify various trends and to ponder on the future ahead.
Lighting Image/Video Style Transfer Methods by Iterative Channel Pruning

Deploying style transfer methods on resource-constrained devices is challenging, which limits their real-world applicability. To tackle this issue, we propose using pruning techniques to accelerate various visual style transfer methods. We argue that typical pruning methods may not be well-suited for style transfer methods and present an iterative correlation-based channel pruning (ICCP) strategy for encoder-transform-decoder-based image/video style transfer models. The correlation-based channel regularization preserves the feature distributions for content and style references, and the iterative pruning strategy prevents layer collapse when pruning on the encoder-decoder structure. Experiments demonstrate that the proposed ICCP can generate visual competitive results compared to SOTA style transfer methods and significantly reduces the number of parameters (at least 70K) and inference time. Model is available at https://github.com/wukx-wukx/ICCP .
Biodiversity Surveyand Molecular Identification of the Phasiinae (Diptera: Tachinidae) of Great Smoky Mountains National Park, USA

Abstract. In contribution to the All Taxa Biodiversity Inventory, a survey of the subfamily Phasiinae (Diptera: Tachinidae) was conducted in Great Smoky Mountains National Park. Phasiines are brightly colored endoparasitoid flies that primarily attack true bugs (Heteroptera) and can be important pollinators in meadow habitats. Collections were made from August to October over a two-year period at two sites: Purchase Knob in Haywood Co., North Carolina in 2013 and Cades Cove in Blount Co., Tennessee in 2014. Phasiines were collected by sweep net and Malaise traps (baited with host pheromone lures and unbaited). Species identifications were made using updated morphological keys, comparisons to identified specimens in collections, and sequence comparisons to known species using the nuclear coding gene MCS. In total, 221 specimens representing 27 tachinid species were collected. Of these, 21 species are newly recorded from the GSMNP, five are new records for Tennessee, and four are new records for North Carolina. All 12 eastern Nearctic phasiine genera were represented. Phasiines of the genus Gymnoclytia were shown to be exceptionally attracted to pheromones of the brown stink bug (Euschistus spp.).
From mirror self-recognition to the looking-glass self: exploring the Justification Hypothesis.

In his Tree of Knowledge (ToK) System, Henriques (2003) posits that the human ego or "self" has evolved because human beings are the only animals that have had to justify their behavior to others. This essay provides evidence for this Justification Hypothesis (JH) from everyday life sociology, starting with the work of George Herbert Mead and Charles Horton Cooley, and focuses on research related to the concept of the "looking-glass self. " Special emphasis is given to the pragmatics of speech acts, the presentation of self in interaction rituals, the accounts given by actors in justification of their actions, and the role of social norms and conformity in the large-scale justification systems commonly called "culture. "
Refraction and eye anterior segment parameters in schizophrenic patients.

PURPOSE To evaluate the difference in terms of refractive errors and anterior segment parameters between schizophrenic patients and healthy volunteers. METHODS This study compared 70 patients (48 men) who were diagnosed with schizophrenia with a control group of 60 (35 men) who were similar in terms of age, gender, education, and socioeconomic level. Anterior segment examination was performed using a Scheimflug system. Axial length and lens thickness (LT) were measured using optic biometry. The following tests were administered to the psychiatric patient group: Brief Psychiatric Rating Scale (BPRS), Scale for the Assessment of Negative Symptoms (SANS), and Scale for the Assessment of Positive Symptoms (SAPS). RESULTS Mild myopia was detected in both the schizophrenic and control groups, with no statistically significant difference (p>0.005). Corneal volume (CV), anterior chamber volume (ACV), anterior chamber depth (ACD), and central corneal thickness (CCT) values were lower in the schizophrenic group, and there was a statistically significant between-group difference (p=0.026, p=0.014, p=0.048, and p=0.005, respectively). LT was greater in schizophrenics, and the difference was found to be statistically significant (p=0.006). A statistically significant negative correlation was found between SAPS and cylinder values (p=0.008). The axial eye length, cylinder value, pupil diameter, mean keratometric value, and anterior chamber angle revealed no statistically significant difference between the groups (p>0.05). CONCLUSION No statistically significant difference was detected in terms of refraction disorders between schizophrenics and the healthy control group, while some differences in anterior chamber parameters were present. These results demonstrate that schizophrenics may exhibit clinical and structural differences in the eye.
Will People Like Your Image?

The wide distribution of digital devices as well as cheap storage allow us to take series of photos making sure not to miss any specific beautiful moment. Thereby, the huge and constantly growing image assembly makes it quite time-consuming to manually pick the best shots afterwards. Even more challenging, finding the most aesthetically pleasing images that might also be worth sharing is a largely subjective task in which general rules rarely apply. Nowadays, online platforms allow users to "like" or favor certain content with a single click. As we aim to predict the aesthetic quality of images, we now make use of such multi-user agreements. More precisely, we assemble a large data set of 380K images with associated meta information and derive a score to rate how visually pleasing a given photo is. predict the aesthetic quality of any arbitrary image or video, we transfer the Our proposed model of aesthetics is validated in a user study. We demonstrate our results on applications for resorting photo collections, capturing the best shot on mobile devices and aesthetic key-frame extraction from videos.
Cloning and expression of a transferrin-binding protein from Actinobacillus pleuropneumoniae

An expression library was constructed from Actinobacillus pleuropneumoniae serotype 7. Escherichia coli transformants expressing recombinant proteins were identified by immunoscreening with porcine convalescent serum. One transformant expressing a 60-kDa protein (60K protein) in aggregated form was identified. Serum raised against the recombinant protein recognized a polypeptide with an indistinguishable electrophoretic mobility in the A. pleuropneumoniae wild type after iron-restricted growth only. The recombinant protein bound transferrin after blotting onto nitrocellulose. Using a competitive enzyme-linked immunosorbent assay (ELISA), the specificity of this binding for the amino-terminal half of iron-saturated porcine transferrin was established. Also, the 60K wild-type protein bound hemin as assessed by hemin-agarose chromatography. Hemin could inhibit transferrin binding of the recombinant protein in the competitive ELISA, whereas hemoglobin and synthetic iron chelators failed to do so. Southern blot analysis of several other A. pleuropneumoniae strains indicated that highly homologous sequence is present in eight of eight isolates of serotype 7 and in some isolates of serotypes 2, 3, and 4.
Interim Results of a Multicenter Trial with the New Electronic Subretinal Implant Alpha AMS in 15 Patients Blind from Inherited Retinal Degenerations

Purpose: We assessed the safety and efficacy of a technically advanced subretinal electronic implant, RETINA IMPLANT Alpha AMS, in end stage retinal degeneration in an interim analysis of two ongoing prospective clinical trials. The purpose of this article is to describe the interim functional results (efficacy). Methods: The subretinal visual prosthesis RETINA IMPLANT Alpha AMS (Retina Implant AG, Reutlingen, Germany) was implanted in 15 blind patients with hereditary retinal degenerations at four study sites with a follow-up period of 12 months (www.clinicaltrials.gov NCT01024803 and NCT02720640). Functional outcome measures included (1) screen-based standardized 2- or 4-alternative forced-choice (AFC) tests of light perception, light localization, grating detection (basic grating acuity (BaGA) test), and Landolt C-rings; (2) gray level discrimination; (3) performance during activities of daily living (ADL-table tasks). Results: Implant-mediated light perception was observed in 13/15 patients. During the observation period implant mediated localization of visual targets was possible in 13/15 patients. Correct grating detection was achieved for spatial frequencies of 0.1 cpd (cycles per degree) in 4/15; 0.33 cpd in 3/15; 0.66 cpd in 2/15; 1.0 cpd in 2/15 and 3.3 cpd in 1/15 patients. In two patients visual acuity (VA) assessed with Landolt C- rings was 20/546 and 20/1111. Of 6 possible gray levels on average 4.6 ± 0.8 (mean ± SD, n = 10) were discerned. Improvements (power ON vs. OFF) of ADL table tasks were measured in 13/15 patients. Overall, results were stable during the observation period. Serious adverse events (SAEs) were reported in 4 patients: 2 movements of the implant, readjusted in a second surgery; 4 conjunctival erosion/dehiscence, successfully treated; 1 pain event around the coil, successfully treated; 1 partial reduction of silicone oil tamponade leading to distorted vision (silicon oil successfully refilled). The majority of adverse events (AEs) were transient and mostly of mild to moderate intensity. Conclusions: Psychophysical and subjective data show that RETINA IMPLANT Alpha AMS is reliable, well tolerated and can restore limited visual functions in blind patients with degenerations of the outer retina. Compared with the previous implant Alpha IMS, longevity of the new implant Alpha AMS has been considerably improved. Alpha AMS has meanwhile been certified as a commercially available medical device, reimbursed in Germany by the public health system.
Resource bounds for self stabilizing message driven protocols

Self-stabilizing message driven protocols are defined and discussed. The class weakexclusion that contains many natural tasks such as `-exclusion and token-passing is defined, and it is shown that in any execution of any self-stabilizing protocol for a task in this class, the configuration size must grow at least in a logarithmic rate. This last lower bound is valid even if the system is supported by a time-out mechanism that prevents communication deadlocks. Then we present three self-stabilizing message driven protocols for token-passing. The rate of growth of configuration size for all three protocols matches the aforementioned lower bound. Our protocols are presented for two processor systems but can be easily adapted to rings of arbitrary size. Our results have an interesting interpretation in terms of automata theory.