Miracle-dz/UniFAR-FTUs huggingface dataset:
The Prognostic Effects of Ventricular Heart Rate Among Patients With Permanent Atrial Fibrillation With and Without Coronary Artery Disease

AbstractHeart rate control is important among patients with either atrial fibrillation (AF) or coronary artery disease (CAD). However, the relationship between the ventricular heart rate and adverse outcomes among patients with AF and CAD remains unclear. This study aimed to assess the prognostic effects of ventricular heart rate in patients with permanent AF (permAF) and CAD.We performed a multicenter, prospective, observational study of patients with AF in China. Patients≥18 years old with permAF were included and divided into a CAD group and a non-CAD group. All patients underwent 1 year of follow-up. The primary outcome was total mortality. Cox proportional hazard models were used to evaluate the relationship between risk factors and the survival rate in the study population.A total of 852 patients (69.1±12.7 years old, 43.3% male, 44.7% with CAD) were included in the analysis. Patients with CAD were older, were more likely to be male and exhibited higher prevalences of hypertension, diabetes mellitus, LV dysfunction, chronic obstructive pulmonary disease (COPD) and stroke compared with patients without CAD. During the follow-up period, a higher total mortality rate was noted in the CAD group than in the non-CAD group (21.5% vs 15.5%, P = 0.023). In the patients without CAD, the lowest quartile (⩽76 beats/min) exhibited the best 1-year survival rate; however, in the patients with CAD, the highest quartile (>110 beats/min) exhibited the worst survival rate. Multivariate adjusted Cox analysis indicated that age (HR 1.039, 95% CI 1.025–1.055, P < 0.001) and heart rate (P = 0.004) were each independently associated with total mortality.Patients with CAD have more risk factors, and comorbidities and higher mortality rates than patients without CAD. In the patients with permAF without CAD, a ventricular rate of ⩽76 beats/minute was associated with the best survival rate; however, among the patients with CAD, no increased mortality was observed unless the heart rate was >110 beats/min.
Absorption systems in the spectrum of GRB 021004

We report on a 3600 s spectrum of GRB 021004 obtained with the Nordic Optical Telecope on La Palma 10.71 hours after the burst. We identify absorption lines from five systems at redshifts 1.3806, 1.6039, 2.2983, 2.3230, and 2.3292. In addition we find an emission line which, if due to Ly from the host galaxy, gives a redshift of 2.3351. The nearest absorber is blueshifted by 530 km s 1 with respect to this line, consistent with shifts seen in Damped Ly and Lyman-Break galaxies at similar redshifts. The emission line flux is 2:46 0:50 10 16 erg s 1 cm 2 . Some of the absorption systems are "line-locked", an eect often seen in QSO absorption systems believed to originate close to the QSO central engine.
Strategic issues in customer relationship management (CRM) implementation

The number of customer relationship management (CRM) implementations has grown dramatically in recent years. However, few academic studies of the issues associated with the implementation of the concept are available. This paper offers a modest contribution through the analysis of a case study of a CRM implementation at a UK‐based manufacturing company. The case study illustrates that CRM is a complex and holistic concept, organised around business processes and the integration of information technologies. The study also highlights that implementing CRM requires effective leadership, sourcing, targeting and evaluation strategies.
Ultraluminous infrared galaxies at high redshift: their position on the Madau plot and their fate

ABSTRA C T A major recent development in extragalactic astronomy has been the discovery of a population of galaxies that is luminous at submillimetre wavelengths. Estimates of their spectral energy distributions suggest that these galaxies are the high-redshift analogues of the ultraluminous infrared galaxies (ULIRGs) observed locally. Here we investigate the implications for the galaxy formation problem if this is indeed the case. We identify plausible (but non-unique) redshift-dependent galaxy luminosity functions that are consistent with both source counts at 2800, 850, 450 and 175 mm and far-infrared background radiation intensities at 850, 240 and 140 mm. In all our models, most of the submillimetre-luminous sources are distant galaxies with high bolometric luminosities $10 12 L(. As for many local ULIRGs, it is not possible to determine whether these luminous galaxies are powered by starbursts, like the local galaxy Arp 220, or by active galactic nuclei (AGN), like the local galaxy Markarian 231. We investigate both possibilities. If the submillimetre-luminous galaxies are all starbursts, then we predict that the fraction of the cosmic star formation rate in these objects is large, but does not necessarily dominate the star formation rate of the Universe ‐ the Madau plot ‐ at any redshift. Only a few per cent by mass of the present-epoch spheroidal stellar population would have been formed in such a population of star-forming galaxies, consistent with the constraints on the number of galaxies with old stellar populations in the field at low and intermediate redshifts derived from K-band surveys. If the submillimetre-luminous galaxies are all powered by AGN, then the comoving density of supermassive black holes on to which material is accreting at high redshift probably equals no more than a few per cent of the local density of massive dark objects.
Configurable high-throughput decoder architecture for quasi-cyclic LDPC codes

We describe a fully reconfigurable low-density parity check (LDPC) decoder for quasi-cyclic (QC) codes. The proposed hardware architecture is able to decode virtually any QC-LDPC code that fits into the allocated memories while achieving high decoding throughput. Our VLSI implementation has been optimized for the IEEE 802.11 n standard and achieves a throughput of 780 Mbit/s with a core area of 3.39 mm2 in 0.18 mum CMOS technology.
Improving multi-view image classification using higher order information and triangulation embedding

In this paper we take a look at extensions of the Bag of Words model developed within the last few years. Namely the aggregation of vector residuals known as VLAD encodings and Fisher kernels and assess their performance for the classification task using multiple views. We also take a look at the triangular embedding strategy for classification in the compression domain. Our work focuses on using the binary descriptor known as ORB. We are also able to show that triangular embedding is extremely fast and can provide the best performance without direct spatial encoding on the images themselves and we also demonstrate a novel approach to improve the triangulation accuracy that is less prone to overfitting than the traditional approach. We are able to show that higher order information provides improved performance in the multiple view setting. We finally take a look at the use of multiple view classification for fast image classification with a variable number of views and that our approach using a modified triangular embedding can overcome information loss and be used real-time.
Contrasting genetic paths to morphological and physiological evolution

The relative importance of protein function change and gene expression change in phenotypic evolution is a contentious, yet central topic in evolutionary biology. Analyzing 5,199 mouse genes with recorded mutant phenotypes, we find that genes exclusively affecting morphological traits when mutated (dubbed “morphogenes”) are grossly enriched with transcriptional regulators, whereas those exclusively affecting physiological traits (dubbed “physiogenes”) are enriched with channels, transporters, receptors, and enzymes. Compared to physiogenes, morphogenes are more likely to be essential and pleiotropic and less likely to be tissue specific. Morphogenes evolve faster in expression profile, but slower in protein sequence and gene gain/loss than physiogenes. Thus, morphological and physiological changes have a differential molecular basis; separating them helps discern the genetic mechanisms of phenotypic evolution.
Efficacy and safety of flexibly dosed paliperidone palmitate in Chinese patients with acute schizophrenia: an open-label, single-arm, prospective, interventional study

This open-label, single-arm, multicenter, 13-week, prospective study explored the efficacy, safety, and tolerability of paliperidone palmitate (150 milligram equivalents [mg eq] [day 1], 100 mg eq [day 8], both deltoid injections; 75–150 mg eq, deltoid/gluteal injection) in Chinese patients with acute schizophrenia (Positive and Negative Syndrome Scale [PANSS] total score ≥70), who previously had unsatisfactory therapeutic effect following oral antipsychotic treatment (without washout period). Primary efficacy endpoint was percentage of patients with ≥30% improvement in the PANSS total score at the end of 13 weeks. Secondary efficacy endpoints included change from baseline to end of week 13 in PANSS total score, PANSS subscale scores, Marder factor scores, Clinical Global Impressions–Severity score, and Personal and Social Performance Scale scores. Overall, 477/610 enrolled patients (full analysis set, 78.2%) completed the study (men: 55.1%; women: 44.9%; mean age: 31.5 years). Total, 443/610 (72.6%, full analysis set) patients achieved primary endpoint (mean [standard deviation] change from baseline: –30.9 [19.51]). All secondary endpoints demonstrated significant improvement at the end of 13 weeks. One death occurred during this acute phase. The most common (>5%) treatment-emergent adverse events were extrapyramidal disorders (8.4%). The efficacy and safety data are consistent with other short-term, placebo-controlled studies of paliperidone palmitate conducted in similar populations.
Outcomes of Ahmed glaucoma valve implantation in advanced primary congenital glaucoma with previous surgical failure

Purpose The purpose of this study was to evaluate the intermediate surgical results of Ahmed glaucoma valve (AGV) implantation in patients less than 7 years of age, with advanced primary congenital glaucoma who have failed previous surgeries. Patients and methods Consecutive patients with advanced primary congenital glaucoma that failed previous operations and had undergone subsequent AGV implantation were evaluated retrospectively. Surgical success was defined as 1) intraocular pressure (IOP) ≥6 and ≤21 mmHg; 2) IOP reduction of at least 30% relative to preoperative values; and 3) without the need for additional surgical intervention for IOP control, loss of light perception, or serious complications. Results Fourteen eyes of eleven patients were studied. Preoperatively, the average axial length was 27.71±1.52 (25.56–30.80) mm, corneal diameter was 14.71±1.07 (13.0–16.0) mm, cup-to-disc ratio was 0.95±0.04 (0.9–1.0), and IOP was 39.5±5.7 (30–55) mmHg. The mean follow-up time was 18.29±10.96 (5–44, median 18) months. There were significant reductions in IOPs and the number of glaucoma medications (P<0.001) postoperatively. The IOPs after operation were 11.3±3.4, 13.6±5.1, 16.3±2.7, and 16.1±2.6 mmHg at 1 month, 6 months, 12 months, and 18 months, respectively. Kaplan–Meier estimates of the cumulative probability of valve success were 85.7%, 71.4%, and 71.4% at 6, 12, and 18 months, respectively. Severe surgical complications, including erosion of tube, endophthalmitis, retinal detachment, choroidal detachment, and delayed suprachoroidal hemorrhage, occurred in 28.6% cases. Conclusion AGV implantation remains a viable option for patients with advanced primary congenital glaucoma unresponsive to previous surgical intervention, despite a relatively high incidence of severe surgical complications.
EMPATHY AND INTERGROUP RELATIONS

Empathy has received increasing empirical attention in the study of intergroup relations. Much of this research has focused on the potential of interventions that generate empathy for improving intergroup attitudes and reducing intergroup bias. Specifically, this work typically explores how empathy mediates the effects of various manipulations, such as direct instructions to imagine how an outgroup member feels on participants' attitudes toward the outgroup as a whole. In this chapter, we offer complementary perspectives on the role of empathy in intergroup relations. In addition, we examine other potential roles of empathy in intergroup relations, considering the direct impact of intergroup empathy on behavior and how intergroup attitudes can moderate the arousal of empathy and its subsequent intergroup impact. We consider three perspectives on the relations among empathy, intergroup attitudes, and group membership. Our goal is not to test these as corn-
Radiofrequency Ablation of Liver Metastases from Colorectal Cancer: A Literature Review

Liver metastases occur in up to 60% of patients with colorectal cancer, and the control of liver metastases is considered to be of primary importance because it is a critical factor in determining prognosis. Radiofrequency ablation (RFA) therapy is one of the least invasive techniques for unresectable hepatic malignancies and can be performed safely using percutaneous, laparoscopic, or open surgical techniques. The local tumor progression rates after RFA for colorectal liver metastases range from 8.8% to 40.0%, and 5-year survival rates range from 20.0% to 48.5%. No prospective, randomized trials comparing the efficacy of RFA with that of surgical resection for colorectal liver metastases are currently available. However, some retrospective studies have reported that patients who received RFA had a survival rate similar to that observed in surgically treated groups, while other studies have reported better survival among patients who underwent surgical resection. The use of a laparoscopic or open surgical approach allows the repeated placement of RFA electrodes at multiple sites to ablate larger tumors. An accurate evaluation of treatment response is very important for the success of RFA therapy because a sufficient safety margin (at least 0.5 cm) can prevent local tumor progression. This review critically summarizes the current status of RFA for liver metastases from colorectal cancer.
Recent Changes in Breast Cancer Incidence in Spain, 1980–2004

Background Since the 1980s, Spain experienced two decades of sharply increasing breast cancer incidence. Declines in breast cancer incidence have recently been reported in many developed countries. We examined whether a similar downturn might have taken place in Spain in recent years. Methods Cases of invasive female breast cancer were drawn from all population-based Spanish cancer registries that had at least 10 years of uninterrupted registration over the period 1980–2004. Overall and age-specific changes in incidence rates were evaluated using change-point Poisson models, which allow for accurate detection and estimation of trend changes. All statistical tests were two-sided. Results A total of 80 453 incident cases of invasive breast cancer were identified. Overall age- and registry-adjusted incidence rates rose by 2.9% (95% confidence interval [CI] = 2.7% to 3.1%) annually during the 1980s and 1990s; there was a statistically significant change in this trend in 2001 (95% CI = 1998 to 2004; P value for the existence of a change point <.001), after which incidence declined annually by 3.0% (95% CI = 1.8% to 4.1%). This trend differed by age group: There was a steady increase in incidence for women younger than 45 years, an abrupt downturn in 2001 for women aged 45–64 years, and a gradual leveling off in 1995 for women aged 65 years or older. Separate analyses for registries that had at least 15 years of uninterrupted registration detected a statistically significant interruption of the previous upward trend in breast cancer incidence in provinces that had aggressive breast cancer screening programs and high screening participation rates, including Navarra (change point = 1991, P < .001), Granada (change point = 2002, P = .003), Bizkaia (change point = 1998, P < .001), Gipuzkoa (change point = 1998, P = .001), and Araba (change point = 1997, P = .002). Conclusions The recent downturn in breast cancer incidence among Spanish women older than 45 years is best explained by a period effect linked to screening saturation.
A Situation-Adaptive Lane-Keeping Support System: Overview of the SAFELANE Approach

Going beyond standard lane-departure-avoidance systems, this paper addresses the development of a system that is able to deal with a large set of different traffic situations. Its foundation lies on a thoroughly constituted environment detection through which a decision system is built. From the output of the decision module, the driver is warned or corrected through suited actuators that are coupled to control strategies. The input to the system comes from cameras, which are supplemented by active sensors (such as radar and laser scanners) and vehicle dynamic data, digital road maps, and precise vehicle-positioning data. In this paper, the presented system design is divided into three layers: the perception layer, which is responsible for the environment perception, and the decision and action layers, which are responsible for evaluating and executing actions, respectively.
Polymorphisms and resistance mutations of hepatitis C virus on sequences in the European hepatitis C virus database

AIM To evaluate the occurrence of resistant mutations in treatment-naïve hepatitis C virus (HCV) sequences deposited in the European hepatitis C virus database (euHCVdb). METHODS The sequences were downloaded from the euHCVdb (https://euhcvdb.ibcp.fr/euHCVdb/). The search was performed for full-length NS3 protease, NS5A and NS5B polymerase sequences of HCV, separated by genotypes 1a, 1b, 2a, 2b and 3a, and resulted in 798 NS3, 708 NS5A and 535 NS5B sequences from HCV genotypes 1a, 1b, 2a, 2b and 3a, after the exclusion of sequences containing errors and/or gaps or incomplete sequences, and sequences from patients previously treated with direct antiviral agents (DAA). The sequence alignment was performed with MEGA 6.06 MAC and the resulting protein sequences were then analyzed using the BioEdit 7.2. 5. for mutations associated with resistance. Only positions that have been described as being associated with failure in treatment in in vivo studies, and/or as conferring a more than 2-fold change in replication in comparison to the wildtype reference strain in in vitro phenotypic assays were included in the analysis. RESULTS The Q80K variant in the NS3 gene was the most prevalent mutation, being found in 44.66% of subtype 1a and 0.25% of subtype 1b. Other frequent mutations observed in more than 2% of the NS3 sequences were: I170V (3.21%) in genotype 1a, and Y56F (15.93%), V132I (23.28%) and I170V (65.20%) in genotype 1b. For the NS5A, 2.21% of the genotype 1a sequences have the P58S mutation, 5.95% of genotype 1b sequences have the R30Q mutation, 15.79% of subtypes 2a sequences have the Q30R mutation, 23.08% of subtype 2b sequences have a L31M mutation, and in subtype 3a sequences, 23.08% have the M31L resistant variants. For the NS5B, the V321L RAV was identified in 0.60% of genotype 1a and in 0.32% of genotype 1b sequences, and the N142T variant was observed in 0.32% of subtype 1b sequences. The C316Y, S556G, D559N RAV were identified in 0.33%, 7.82% and 0.32% of genotype 1b sequences, respectively, and were not observed in other genotypes. CONCLUSION HCV mutants resistant to DAAs are found in low frequency, nevertheless they could be selected and therapy could fail due resistance substitutions in HCV genome.
Addressing Post-traumatic Stress and Aggression by Means of Narrative Exposure: A Randomized Controlled Trial with Ex-Combatants in the Eastern DRC

Former child soldiers and ex-combatants are at high risk of developing trauma-related disorders and appetitive aggression, which reduce successful integration into peaceful societies. In a randomized controlled clinical trial, we offered Narrative Exposure Therapy for Forensic Offender Rehabilitation (FORNET) to 15 ex-combatants with the goal of reducing traumatic stress and appetitive aggression compared to “treatment as usual. ” Measures included the PTSD Symptom Scale-Interview and the Appetitive Aggression Scale assessed prior to treatment and 2 weeks and 6 months after the treatment. We also assessed closeness to combatants as an index of reintegration. The treatment group reported reduced PTSD symptoms and less contact with combatants. Appetitive aggression decreased substantially in both groups. The results indicate that it is feasible to add psychological treatment to facilitate the reintegration process. We wish to thank the former combatants and former child soldiers who participated in this study and the Congolese translators. We also want to thank the very motivated and reliable staff of the reintegration center, especially Pascal Badibanga Zagabe, Leonce Kyakimwa, Lydie Mirimo Ajua, David Ngufu, and Matata Banyene. Furthermore, we want to thank Charlotte Salmen for conducting the follow-up interviews and James Moran for conducting the follow-up interviews as well as proofreading the manuscript. Sources of support: Deutsche Forschungsgemeinschaft (DFG), vivo international. Trial registration clinicaltrials.gov Identifier: NCT01625117
ASUPAN KALSIUM DAN VITAMIN C DENGAN TINGGI BADAN SISWA SD NEGERI INPRES BERU-BERU KECAMATAN KALUKKU KABUPATEN MAMUJU

Anak sekolah dasar merupakan sasaran strategis dalam perbaikan gizi masyarakat karena pada masa ini tumbuh kembang anak mulai terbentuk mantap. Masalah stunting atau anak yang pendek dapat dipengaruhi oleh kekurangan berbagai macam zat gizi, tidak cukupnya asupan zat gizi tersebut seperti protein, kalsium dan lain-lain akan beresiko terjadinya stunting atau anak yang pendek. Jenis penelitian ini adalah bersifat analitik dengan desain penelitian cross Sectional Study. Sampel dalam penelitian ini adalah sebanyak 65 orang yang diperoleh dengan cara purposive sampling . Asupan kalsium dan vitamin C diambil denga recall 24 jam, sedangkan tinggi badan diukur dengan menggunakan microtoice, kemudian dianalisis menggunakan chi square . Hasil penelitian menunjukkan bahwa terdapat 76,9 % yang berstatus gizi pendek (stunting)menurut indikator TB/U, terdapat 100 % anak yang memiliki asupan kalsium yang kurang, dan 96,9 % yang asupan vitamin C kurang. Hasil penelitian tidak menunjukkan adanya hubungan antara asupan kalsium dan vitamin C dengan tinggi badan anak.
On the Hydration State of Amino Acids and Their Derivatives at Different Ionization States: A Comparative Multinuclear NMR and Crystallographic Investigation

2D, 13C, 14N, and 17O NMR and crystallographic data from the literature were critically evaluated in order to provide a coherent hydration model of amino acids and selected derivatives at different ionization states. 17O shielding variations, longitudinal relaxation times (T 1) of 2D and 13C and line widths (Δν 1/2) of 14N and 17O, may be interpreted with the hypothesis that the cationic form of amino acids is more hydrated by 1 to 3 molecules of water than the zwitterionic form. Similar behaviour was also observed for N-acetylated derivatives of amino acids. An exhaustive search in crystal structure databases demonstrates the importance of six-membered hydrogen-bonded conjugated rings of both oxygens of the α-carboxylate group with a molecule of water in the vicinity. This type of hydrogen bond mode is absent in the case of the carboxylic groups. Moreover, a considerable number of structures was identified with the propensity to form intramolecular hydrogen bond both in the carboxylic acid (NH⋯O=C) and in the carboxylate (NH ⋯ O−) ionization state. In the presence of bound molecules of water this interaction is significantly reduced in the case of the carboxylate group whereas it is statistically negligible in the carboxylic group.