Miracle-dz/UniFAR-FTUs huggingface dataset:
Service-Oriented Computing

Service-oriented computing is a computing paradigm based on the ServiceOriented Architecture (SOA), which is an architectural style for building software applications out of services available in a network such as the Web. SOA promotes loose coupling between software components so that they can be reused. Services are implementations of well-defined business functionality, and such services can be consumed by clients in different applications or business processes. SOA provides a level of flexibility that was not possible before in the sense that services are software components with well-defined interfaces that are implementation independent, that services can be dynamically discovered, and composite services can be built from aggregates of other services. SOA uses the find-bind-execute paradigm whereby service providers register their services in a public registry. This registry is used by consumers to find services that match certain criteria. If the registry has such a service, it provides the consumer with a contract and an end point address for that service. The most widely used technology for realizing the SOA paradigm is
Mode of Action: Impaired Fetal Leydig Cell Function—Effects on Male Reproductive Development Produced by Certain Phthalate Esters

Certain phthalate esters (di-2-ethylhexyl; di-n-butyl and butyl benzyl) have profound effects on the developing male reproductive system when administered orally to pregnant experimental animals during a critical window of development. These esters produce a syndrome of adverse effects that are characteristic of a disturbance in androgen-mediated development and include a variety of reproductive tract malformations and effects on developmental phenotypic markers. A testicular dysgenesis syndrome has been proposed to explain the secular increases in a number of human male reproductive deficits, including decreased semen parameters, increased incidence of cryptorchidism and hypospadias (two of the most common human birth defects), and increased incidence of testicular (germ cell derived) cancer. The rodent phthalate data lend support to the hypothesis. This example illustrates a number of points in the use of the Human Relevance Framework. First, chemical agents may have more than one mode of action (MOA): for example, phthalate-induced peroxisome proliferation leading to hepatocarcinogensis, compared with the induction of developmental effects via effects on androgen signaling. Second, the case demonstrates the life-stage sensitivity of the response to these compounds. Third, because humans may be exposed to multiple phthalate esters producing adverse effects on reproductive development, these compounds may be useful in testing the utility of the Human Relevance Framework (HRF) approach for evaluating cumulative and aggregate risk.
The CP4 transgene provides high levels of tolerance to Roundup® herbicide in field-grown hybrid poplars

We tested two genes together in hybrid poplars (genus Populus), CP4 and GOX, for imparting tolerance to glyphosate (the active ingredient in Roundup ® herbicide). Using Agrobacterium-based transformation, 80 independent transgenic lines (i.e., products of asexual gene transfer) were produced in a variety of hybrid poplar clones (40 lines in Populus trichocarpa Torr. & Gray × Populus deltoides Bartr., 35 lines in Populus tremula L. × Populus alba L., and five lines in P. tremula × Populus tremuloides Michx.). We evaluated glyphosate tolerance over 2 years in field studies conducted in eastern and western Oregon. Ten percent of our transgenic lines showed no foliar damage or reduced growth after being sprayed with Roundup ® at concentrations above normal commercial rates. Lack of damage was as- sociated with expression of the CP4 gene but not of the GOX gene. It was suspected that GOX caused undesirable side effects, so we produced 12 lines into which only the CP4 gene was inserted. The performance of these newly regener- ated lines was compared with an identical number of lines, produced in the same genotype, that had previously been engineered to contain both CP4 and GOX. Growth of the lines transformed with just CP4 was significantly better than those containing both genes and exhibited less damage in response to glyphosate treatment. This is the first report of transgenic poplars exhibiting high levels of glyphosate tolerance when grown under field conditions. With a modest transformation effort, it is possible to produce lines with commercially useful levels of glyphosate tolerance and little apparent collateral genetic damage. 976
Maintenance Treatment With Proton Pump Inhibitors for Reflux Esophagitis in Pediatric Patients: A Systematic Literature Analysis

Objectives: Short-term treatment with a proton pump inhibitor (PPI) is effective for healing reflux esophagitis and improving reflux symptoms in pediatric patients. Our aim was to assess the efficacy and tolerability of maintenance PPI treatment after healing of reflux esophagitis in pediatric patients. Materials and Methods: Systematic searches of MEDLINE, Excerpta Medica database, and recent conference abstracts. Results: Five studies evaluated the efficacy of PPI maintenance therapy (6- to 90-month follow-up) in pediatric patients after healing of reflux esophagitis. Three found no relapse of reflux esophagitis or reflux symptoms during PPI maintenance therapy; however, a low relapse rate (1/14) was also found in the placebo group of the only prospective controlled study. Two of the 5 studies (both prospective) reported relapse of reflux esophagitis at half the original healing dose of omeprazole (7 of 51 patients relapsed after 3 months; 8 of 32 within 21 months), which resolved again in most patients when the healing dose or higher was given. Four studies evaluated relapse of reflux esophagitis and/or reflux symptoms after stopping PPI therapy. Reflux symptoms recurred in 18% to 76% of patients across all 4 studies. In the 4 studies that assessed the safety of PPI maintenance therapy, adverse events were infrequent and of low severity. Conclusions: Pediatric patients with gastroesophageal reflux disease and certain chronic comorbidities appear to have the greatest need of maintenance PPI treatment after healing of reflux esophagitis. In patients requiring maintenance therapy, PPIs appear to be well tolerated and effective in maintaining remission of reflux esophagitis and reflux symptoms.
Ex Situ Inhibition of Hepatic Uptake and Efflux Significantly Changes Metabolism: Hepatic Enzyme-Transporter Interplay

The disposition of digoxin and the influence of the organic anion transporting polypeptide (Oatp)2 inhibitor rifampicin and the P-glycoprotein (P-gp) inhibitor quinidine on its hepatic disposition were examined in the isolated perfused rat liver. Livers from groups of rats were perfused in a recirculatory manner after a bolus dose of digoxin (10 μg), a dual substrate for Oatp2 and P-gp as well as CYP3A. Perfusions of digoxin were also examined in groups of rats in the presence of the inhibitors: rifampicin (100 μM) or quinidine (10 μM). In all experiments, perfusate samples were collected for 60 min. Digoxin and its primary metabolite were determined in perfusate and liver by liquid chromatography/mass spectrometry. The area under the curve (AUC) from 0 to 60 min was determined. The AUC ± S.D. of digoxin was increased from control (3880 ± 210 nM·min) by rifampicin (5200 ± 240 nM·min; p < 0.01) and decreased by quinidine (3220 ± 340 nM·min; P < 0.05). It is concluded that rifampicin limits the hepatic entrance of digoxin and reduced the hepatic exposure of digoxin to CYP3A by inhibiting the basolateral Oatp2 uptake transport, whereas quinidine increased the hepatic exposure of digoxin to CYP3A by inhibiting the canalicular P-gp transport. These data emphasize the importance of uptake and efflux transporters on hepatic drug metabolism.
Evaluating the use of a virtual learning environment for teaching aspects of HCI

In this paper, we describe the results of evaluating a taught module in Human-Computer Interaction (HCI). The focus of this paper is on the use of a virtual learning environment (VLE) - in the case WebCT - as a vehicle for both the taught content and assessment and for demonstrating important aspects of HCI. Evidence of student learning is presented and evaluated, including examples of work submitted through the VL, and the results of an evaluation questionnaire.
From cutting planes algorithms to compression schemes and active learning

Cutting-plane methods are well-studied localization (and optimization) algorithms. We show that they provide a natural framework to perform machine learning -and not just to solve optimization problems posed by machine learning- in addition to their intended optimization use. In particular, they allow one to learn sparse classifiers and provide good compression schemes. Moreover, we show that very little effort is required to turn them into effective active learning methods. This last property provides a generic way to design a whole family of active learning algorithms from existing passive methods. We present numerical simulations testifying of the relevance of cutting-plane methods for passive and active learning tasks.
Site‐specific genetic divergence in parallel hybrid zones suggests nonallopatric evolution of reproductive barriers

The evolution of reproductive isolation in the presence of gene flow is supported by theoretical models but rarely by data. Empirical support might be gained from studies of parallel hybrid zones between interbreeding taxa. We analysed gene flow over two hybrid zones separating ecotypes of Littorina saxatilis to test the expectation that neutral genetic markers will show site‐specific differences if barriers have evolved in situ. Distinct ecotypes found in contrasting shore habitats are separated by divergent selection and poor dispersal, but hybrid zones appear between them. Swedish islands formed by postglacial uplift 5000 years ago provide opportunities to assess genetic structure in a recently evolved system. Each island houses a discrete population containing subpopulations of different ecotypes. Hybrid zones between ecotypes may be a product of ecological divergence occurring on each island or a consequence of secondary overlap of ecotypes of allopatric origin that have spread among the islands. We used six microsatellite loci to assess gene flow and genetic profiles of hybrid zones on two islands. We found reduced gene flow over both hybrid zones, indicating the presence of local reproductive barriers between ecotypes. Nevertheless, subpopulations of different ecotypes from the same island were genetically more similar to each other than were subpopulations of the same ecotype from different islands. Moreover, neutral genetic traits separating the two ecotypes across hybrid zones were site‐specific. This supports a scenario of in situ origin of ecotypes by ecological divergence and nonallopatric evolution of reproductive barriers.
Rapid Gastric Emptying Is More Common than Gastroparesis in Patients With Autonomic Dysfunction

OBJECTIVES:Autonomic dysfunction is associated with a wide variety of gastrointestinal symptoms. It is unclear how many patients with autonomic dysfunction have slow or rapid gastric emptying. The aim of this study was to determine the prevalence of rapid and delayed solid phase gastric emptying in patients with autonomic dysfunction referred for evaluation of gastrointestinal symptoms and the association of emptying rate with clinical symptoms.METHODS:Retrospective review of all patients with autonomic dysfunction who had a gastric emptying test from January, 1996 to March, 2005. Demographic data, clinical symptoms, composite autonomic scoring scale (CASS) score, and gastric emptying parameters were analyzed.RESULTS:Sixty-one subjects (women 49, age 42 [16–74] yr) with autonomic dysfunction were reviewed. Patients had mild-to-moderate (mean CASS score 3) autonomic dysfunction. Twenty-seven, 17, and 17 patients had rapid, normal, and delayed gastric emptying t1/2, respectively. In addition, 10 patients had initially rapid emptying in phase 1, with subsequent slowing in phase 2 to produce an overall normal or delayed t1/2. There was no difference in demographic data or CASS score among the three groups. More patients with initial or overall rapid emptying had diarrhea (70%) compared to patients with normal (33%) or delayed (33%) emptying (P = 0.018). CONCLUSIONS:Unexpectedly, more patients with autonomic dysfunction have rapid rather than delayed gastric emptying. The presence of diarrhea in patients with autonomic symptoms should prompt consideration for the presence of rapid gastric emptying. Conversely, the finding of rapid gastric emptying in patients with gastrointestinal symptoms should prompt consideration for the presence of underlying autonomic dysfunction.
Biocompatibility of reduced graphene oxide nanoscaffolds following acute spinal cord injury in rats

Background: Graphene has unique electrical, physical, and chemical properties that may have great potential as a bioscaffold for neuronal regeneration after spinal cord injury. These nanoscaffolds have previously been shown to be biocompatible in vitro; in the present study, we wished to evaluate its biocompatibility in an in vivo spinal cord injury model. Methods: Graphene nanoscaffolds were prepared by the mild chemical reduction of graphene oxide. Twenty Wistar rats (19 male and 1 female) underwent hemispinal cord transection at approximately the T2 level. To bridge the lesion, graphene nanoscaffolds with a hydrogel were implanted immediately after spinal cord transection. Control animals were treated with hydrogel matrix alone. Histologic evaluation was performed 3 months after the spinal cord transection to assess in vivo biocompatibility of graphene and to measure the ingrowth of tissue elements adjacent to the graphene nanoscaffold. Results: The graphene nanoscaffolds adhered well to the spinal cord tissue. There was no area of pseudocyst around the scaffolds suggestive of cytotoxicity. Instead, histological evaluation showed an ingrowth of connective tissue elements, blood vessels, neurofilaments, and Schwann cells around the graphene nanoscaffolds. Conclusions: Graphene is a nanomaterial that is biocompatible with neurons and may have significant biomedical application. It may provide a scaffold for the ingrowth of regenerating axons after spinal cord injury.
STATISTICAL PHYSICS OF DISLOCATION NUCLEATION BY NANOINDENTATION

Current understanding of the onset of plasticity during nanoindentation of crystalline materials involves homogenous dislocation nucleation in the crystal underneath the indenter. Through the use of cutting-edge nanoindentation techniques, this study examines the initiation of plastic deformation in single crystal oriented platinum samples. Variations in the temperature and loading rate during indentation reveal temporal and thermal dependencies, and support the stochastic and thermally-activated nature of the initial plastic event. These dependencies of dislocation nucleation are precisely quantified by developing analysis methods based on statistical thermodynamics, and are used to evaluate the probability of various atomistic mechanisms. The results of this procedure implicate a critical activation event occurring in a single atomic volume, with an activation enthalpy of a fraction of an electron volt. These findings strongly indicate that the initiation of plasticity begins with a heterogeneous dislocation nucleation event, in conflict with the current belief, and significantly advance understanding of the onset of plastic deformation during nanoindentation. Thesis Supervisor: Christopher Schuh Title: Assistant Professor of Materials Science and Engineering
Circulation of Japanese Encephalitis Virus in Pigs and Mosquito Vectors within Can Tho City, Vietnam

Japanese encephalitis virus (JEV) is a mosquito-borne, zoonotic flavivirus causing encephalitis in humans and reproductive disorder in pigs. JEV is present in large parts of Asia, where urbanization is high. Households within and outside Can Tho city, South Vietnam, were selected to monitor circulation of JEV. A nested RT-PCR was established to detect the presence of JEV in mosquitoes whereas sera from pigs belonging to households within the province were analyzed for the presence of antibodies to JEV. A total of 7885 mosquitoes were collected and divided into 352 pools whereof seven were JEV-positive, six of which were collected within the city. Fragments from four pools clustered with JEV genotype III and three with genotype I. Of the 43 pigs sampled inside the city 100% had JEV antibodies. Our study demonstrates exposure to JEV in pigs, and co-circulation of JEV genotype I and III in mosquitoes within an urban environment in South Vietnam. Thus, although JEV has mainly been considered a rural disease, the potential for transmission in urban areas cannot be ignored.
Different Patterns in Daytime and Nighttime Thermal Effects of Urbanization in Beijing-Tianjin-Hebei Urban Agglomeration

Surface urban heat island (SUHI) in the context of urbanization has gained much attention in recent decades; however, the seasonal variations of SUHI and their drivers are still not well documented. In this study, the Beijing-Tianjin-Hebei (BTH) urban agglomeration, one of the most typical areas experiencing drastic urbanization in China, was selected to study the SUHI intensity (SUHII) based on remotely sensed land surface temperature (LST) data. Pure and unchanged urban and rural pixels from 2000 to 2010 were chosen to avoid non-concurrency between land cover data and LST data and to estimate daytime and nighttime thermal effects of urbanization. Different patterns of the seasonal variations were found in daytime and nighttime SUHIIs. Specifically, the daytime SUHII in summer (4 °C) was more evident than in other seasons while a cold island phenomenon was found in winter; the nighttime SUHII was always positive and higher than the daytime one in all the seasons except summer. Moreover, we found the highest daytime SUHII in August, which is the growing peak stage of summer maize, while nighttime SUHII showed a trough in the same month. Seasonal variations of daytime SUHII showed higher significant correlations with the seasonal variations of ∆LAI (leaf area index) (R2 = 0.81, r = −0.90) compared with ∆albedo (R2 = 0.61, r = −0.78) and background daytime LST (R2 = 0.69, r = 0.83); moreover, agricultural practices (double-cropping system) played an important role in the seasonal variations of daytime SUHII. Seasonal variations of the nighttime SUHII did not show significant correlations with either of seasonal variations of ∆LAI, ∆albedo, and background nighttime LST, which implies different mechanisms in nighttime SUHII variation needing future studies.
Expression Analysis of Multiple Genes May Involve in Antimony Resistance among Leishmania major Clinical Isolates from Fars Province, Central Iran

Background: Treatment of Cutaneous Leishmaniasis (CL) is being faced with serious difficulties in Fars Province, due to emerging of resistance against meglumine antimonite (Glucantime®). In this context, determining some biomarkers for drug sensitivity monitoring seems to be highly essential. Different studies have been carried out to decipher the genes might be involved in antimony resistant phenotype in Leishmania spp. Here, we selected three genes: AQP (as drug transporter), TDR-1-1(as drug activator), and γ-GCS (inducing reduction environment) for comparative expression analysis on clinical resistant and sensitive isolates of L. major. Methods: The clinical isolates of L. major were collected from CL patients referred to Valfajr Health Center, Shiraz from Oct 2011 to Feb 2012. The susceptibility test was performed to confirm drug sensitivity of strains in vitro as well. Then, the gene expression analysis was performed by quantitative real-time PCR using SYBR® Green. Results: By comparison of expression level between strains, up regulation of γ-GCS gene and down regulation of AQP gene were observed in resistant strains compared to the sensitive isolates; however, down regulation of AQP was not statistically specific. Analysis of TDR-1-1 gene unexpectedly showed a high level of expression in the non-responsive cases. Conclusion: The γ-GCS, at least, can be considered as a suitable molecular marker for screening antimony sensitivity in clinical isolates, although AQP and TDR-1-1gene seem not to be reliable resistant markers.
Impact of Food Source on Survival of Red Flour Beetles and Confused Flour Beetles (Coleoptera: Tenebrionidae) Exposed to Diatomaceous Earth

Abstract A series of experiments was conducted to determine the effect of a flour food source on survival of red flour beetle, Tribolium castaneum (Herbst), and confused flour beetle, Tribolium confusum (DuVal), exposed to the labeled rate (0.5 mg/cm2) of Protect-It, a marine formulation of diatomaceous earth. Beetles were exposed at 27°C, and 40, 57, and 75% RH in 62-cm2 petri dishes. When beetles were exposed for 1 or 2 d in dishes with the labeled rate (0.5 mg/cm2, or 31 mg per dish) of diatomaceous earth or in dishes containing flour at varying levels from 0 to 200 mg mixed with the labeled rate of diatomaceous earth, survival of both species increased as the amount of flour increased, and quickly plateaued at levels approaching 100%. In a second set of experiments, beetles were transferred to dishes containing flour at varying levels from 0 to 200 mg after they were exposed for 1 or 2 d in dishes with the labeled rate of diatomaceous earth alone. There were no significant differences in beetle survival among the levels of flour, however, survival in dishes with flour was usually greater than survival in dishes with diatomaceous earth alone. In a third test, beetles were exposed for 1, 2, and 3 d in dishes with either the labeled rate of diatomaceous earth alone (clean dishes), dishes with diatomaceous earth and empty straws, or dishes with diatomaceous earth and ≈300 mg of flour packed in the straws. Survival was not significantly different between clean dishes or dishes with straws, but survival in dishes containing the straws with flour was usually 100%, regardless of exposure interval. In all experiments, confused flour beetles were less susceptible to diatomaceous earth than red flour beetles. In addition, survival was negatively related to exposure interval and positively related to relative humidity.
Systematic review of compound action potentials as predictors for cochlear implant performance

The variability in speech perception between cochlear implant users is thought to result from the degeneration of the auditory nerve. Degeneration of the auditory nerve, histologically assessed, correlates with electrophysiologically acquired measures, such as electrically evoked compound action potentials (eCAPs) in experimental animals. To predict degeneration of the auditory nerve in humans, where histology is impossible, this paper reviews the correlation between speech perception and eCAP recordings in cochlear implant patients.