Miracle-dz/UniFAR-FTUs huggingface dataset:
Section Ii‐ Exercise Physiology & Sports Medicine Physiological Responses during the Time Limit at 100% of the Peak Velocity in the Carminatti's Test in Futsal Players

The aim of this study was to investigate the physiological responses during the time limit at the intensity of the peak velocity of the Carminatti's test (T-CAR). Ten professional futsal players (age, 27.4 ± 5.8 years, body mass, 78.8 ± 8.5 kg, body height, 175.8 ± 6.8 cm, body fat mass, 14.1 ± 2.6%) took part in the study. The players performed three tests, with an interval of at least 48 hours, as follows: the T-CAR to determine the peak velocity and the maximal heart rate; an incremental treadmill protocol to determine the maximal physiological responses; and a time limit running test at the peak velocity reached in the T-CAR. During the last two tests, a portable gas analyzer was used for direct measurement of cardiorespiratory variables. It was shown that the peak velocity was not significantly different from the maximal aerobic speed achieved in the laboratory (p = 0.213). All athletes reached their maximum oxygen uptake during the time limit test. The maximum oxygen uptake achieved during the time limit test was not different from that observed in the laboratory condition (51.1 ± 4.7 vs. 49.6 ± 4.7 ml·kg-1 ·min-1 , respectively, p = 0.100). In addition, Bland and Altman plots evidenced acceptable agreement between them. On average, athletes took ~140 s to achieve maximum oxygen uptake and maintained it for ~180 s. Therefore, the peak velocity intensity can be used as an indicator of maximal aerobic power of futsal athletes and the time limit can be used as a reference for training prescription.
Mistrust and Endorsement of Human Immunodeficiency Virus Conspiracy Theories Among Human Immunodeficiency Virus-Infected African American Veterans.

INTRODUCTION Human immunodeficiency virus (HIV) has taken a disproportionate toll on the lives of African Americans, and many previous studies suggest HIV conspiracy beliefs and physician mistrust play important roles in this racial disparity. Because many HIV conspiracy theories tie government involvement with the origin and potential cure for HIV, an area for further examination is HIV+ African American veterans in Veterans Health Administration (VHA) care. In addition to HIV conspiracy beliefs, veterans may already be mistrustful of the VHA as a government healthcare provider. This mistrust is significantly associated with poor health outcomes, among both minority and nonminority persons living with HIV. MATERIALS AND METHODS We conducted interviews with 32 African American veterans at three VHA hospitals to assess HIV conspiracy beliefs and mistrust in physicians providing HIV care. A semistructured interview format allowed respondents to talk freely about their personal history with HIV, their perceptions about living with HIV, and their views on HIV conspiracy beliefs. RESULTS Five major themes arose from these interviews, including that the government uses HIV to control minority populations; the Veterans Affairs healthcare providers may play a role in withholding HIV treatment, and many HIV-infected veterans are suspicious of HIV treatment regimens. Additionally, several HIV-infected veterans in our study disclosed that they did not follow the prescribed treatment recommendations to ensure adherence. CONCLUSION A veteran's beliefs drive views of the healthcare system and trust of HIV-infected veterans' healthcare providers, and impact HIV-infected veterans' willingness to accept treatment for their medical conditions. Further research should continue to examine the impact of mistrust and endorsement of conspiracy beliefs among veterans receiving care in VHA.
Intima-Media Thickness of Brachial Artery, Vascular Function, and Cardiovascular Risk Factors

Objective—Cardiovascular diseases are associated with impaired flow-mediated vasodilation (FMD) and increase in carotid intima-media thickness (IMT). Both FMD and IMT are independent predictors for cardiovascular outcomes. When measuring FMD and nitroglycerine-induced vasodilation in the brachial artery, IMT can also be simultaneously assessed in the same brachial artery. The purpose of this study was to determine the relationships between IMT of the brachial artery, vascular function, and cardiovascular risk factors. Methods and Results—We measured brachial IMT, FMD, and nitroglycerine-induced vasodilation by ultrasound in 388 subjects who underwent health examination (mean age, 45±22 years; age range, 19–86), including patients with cardiovascular diseases. Univariate regression analysis revealed that brachial IMT significantly correlated with age (r=0.71; P<0.001), body mass index (r=0.27; P<0.001), systolic blood pressure (r=0.40; P<0.001), diastolic blood pressure (r=0.31; P<0.001), heart rate (r=0.15; P=0.002), glucose level (r=0.18; P=0.01), and smoking pack-years (r=0.42; P<0.001), as well as Framingham risk score, a cumulative cardiovascular risk index for heart attack (r=0.49; P<0.001). FMD and nitroglycerine-induced vasodilation were inversely associated with brachial IMT (r=−0.39, P<0.001; r=−0.32, P<0.001, respectively). In addition, there was a significant relationship between brachial IMT and carotid IMT (r=0.58; P<0.001). Multivariate analysis revealed that age, sex, hypertension, and brachial artery diameter were independent predictors of brachial IMT. Conclusion—These findings suggest that brachial IMT may be a marker of the grade of atherosclerosis and may be used as a marker of vascular function, providing additive information for stratifying subjects with cardiovascular risk factors.
An immunohistologic study of granulomatous inflammation in SIV‐infected rhesus monkeys

We studied granulomatous inflammation in simian AIDS using histologic, immunohistologic, and in situ hybridization techniques. Complete Freund's adjuvant was used to induce granulomas in two control animals and two macaques infected with simian immunodeficiency virus (SIV) and having low peripheral CD4+ T cell counts. Control animals developed large (>2 cm diameter) epithelioid granulomas containing CD68+ macrophages (mφs), epithelioid mφs and multinucleated giant cells (MNGCs), CD4+ and CD8+ T cells, and small perivascular collections of CD20+ B cells. Lymphocytes rarely expressed proliferating cell nuclear antigen (Ki‐67), and only rare endothelial cells expressed vascular cell adhesion molecule 1 (VCAM‐1). In contrast, SIV+ animals had smaller (<0.5 cm diameter) epithelioid granulomas characterized by numerous large, dense CD8+, CD20+ lymphocyte aggregates with prominent local division (Ki‐67+). Despite low blood CD4+ T cell numbers, there was a substantial CD4+ T cell infiltrate, accompanied by enhanced endothelial VCAM‐1 expression. These granulomas contained no detectable SIV antigen or RNA. Thus, in simian AIDS, experimentally induced granulomatous responses are grossly attenuated, yet associated with increased local endothelial‐leukocyte signaling and lymphocyte division.
Advances and Pitfalls in the Analysis and Interpretation of Resting-State FMRI Data

The last 15 years have witnessed a steady increase in the number of resting-state functional neuroimaging studies. The connectivity patterns of multiple functional, distributed, large-scale networks of brain dynamics have been recognised for their potential as useful tools in the domain of systems and other neurosciences. The application of functional connectivity methods to areas such as cognitive psychology, clinical diagnosis and treatment progression has yielded promising preliminary results, but is yet to be fully realised. This is due, in part, to an array of methodological and interpretative issues that remain to be resolved. We here present a review of the methods most commonly applied in this rapidly advancing field, such as seed-based correlation analysis and independent component analysis, along with examples of their use at the individual subject and group analysis levels and a discussion of practical and theoretical issues arising from this data ‘explosion’. We describe the similarities and differences across these varied statistical approaches to processing resting-state functional magnetic resonance imaging signals, and conclude that further technical optimisation and experimental refinement is required in order to fully delineate and characterise the gross complexity of the human neural functional architecture.
Spontaneous growth and pubertal development in Turner's syndrome with different karyotypes

We studied spontaneous growth and pubertal development in 205 girls with Turner's syndrome, aged 1 month to 28.16 years, according to different karyotypes: 45, X (52%), X‐mosaicism (12%), X‐structural abnormalities (36%). Data on height, weight, height velocity, bone age and pubertal development were collected yearly in a mixed longitudinal and cross‐sectional mode. Pelvic ultrasonography was performed in 133 patients, 46 of whom had contact breast thermography. Standards for height and height velocity (1–20 years) showed no differences when compared with other studies. Some differences were found when these data were subdivided by karyotype. In fact, X‐mosaicism subjects had a pubertal growth spurt between 8 and 12 years of age. The spurt observed in this group cannot be justified by the more frequent presence of residual ovarian activity alone. It also appears in patients without ovaries and confirms the influence of a genetic factor on the X‐chromosome. In spite of this spurt, the greatest final height was reached by 45, X subjects. X‐mosaicism girls had more frequent spontaneous breast development linked to a higher percentage of visible ovaries. In this group the age of the first pubertal signs was similar to that of normal subjects and occurred much earlier than in the other groups.
Implications of the Pivot Shift in the ACL-Deficient Knee

The Losee repair controls rotational subluxation of the lateral femoral condyle, or pivot shift, but does not reliably eliminate Lachman laxity. Despite this surgical limitation, many patients who were operated on continued to do high-demand activities at the last followup. We hypothesized that Lachman findings alone did not predict poor surgical outcome or progression to osteoarthritis. We report on 87 patients evaluated at an average of 9 years (range, 5-21 years) postoperatively. Prospectively collected examinations and radiographic, subjective, and objective outcome measures were recorded and statistically evaluated. The presence of a postoperative pivot shift or residual varus laxity correlated with poor patient subjective evaluations and poor scoring outcomes. Lachman laxity with an absent pivot shift had no correlation with the outcome measures or onset of radiographic progression to osteoarthritis. Meniscectomy, additional knee surgery, increased valgus or varus laxity, and time from injury until the final radiograph positively correlated with the onset of osteoarthritis. Elimination of the pivot shift was necessary to achieve successful relief of symptoms and functional outcome. In the absence of a pivot shift, Lachman laxity was not solely predictive of poor outcomes. Level of Evidence: Prognostic study, Level II-1 (retrospective study). See the Guidelines for Authors for a complete description of levels of evidence.
Cell Surface Localization of Tissue Transglutaminase Is Dependent on a Fibronectin-binding Site in Its N-terminal β-Sandwich Domain*

Increasing evidence indicates that tissue transglutaminase (tTG) plays a role in the assembly and remodeling of extracellular matrices and promotes cell adhesion. Using an inducible system we have previously shown that tTG associates with the extracellular matrix deposited by stably transfected 3T3 fibroblasts overexpressing the enzyme. We now show by confocal microscopy that tTG colocalizes with pericellular fibronectin in these cells, and by immunogold electron microscopy that the two proteins are found in clusters at the cell surface. Expression vectors encoding the full-length tTG or a N-terminal truncated tTG lacking the proposed fibronectin-binding site (fused to the bacterial reporter enzyme β-galactosidase) were generated to characterize the role of fibronectin in sequestration of tTG in the pericellular matrix. Enzyme-linked immunosorbent assay style procedures using extracts of transiently transfected COS-7 cells and immobilized fibronectin showed that the truncation abolished fibronectin binding. Similarly, the association of tTG with the pericellular matrix of cells in suspension or with the extracellular matrix deposited by cell monolayers was prevented by the truncation. These results demonstrate that tTG binds to the pericellular fibronectin coat of cells via its N-terminal β-sandwich domain and that this interaction is crucial for cell surface association of tTG.
Assessing the Iterative Finite Difference Mass Balance and 4D‐Var Methods to Derive Ammonia Emissions Over North America Using Synthetic Observations

We evaluate two inverse modeling methods by conducting inversion experiments using the GEOS‐Chem chemical transport model and its adjoint. We simulate synthetic NH3 column density as observed by the Cross‐track Infrared Sounder over North America to test the ability of the iterative finite difference mass balance (IFDMB) and the four‐dimensional variational assimilation (4D‐Var) methods to recover known NH3 emissions. Comparing to the more rigorous 4D‐Var method, the IFDMB approach requires 3–4 times lower computational cost and yields similar or smaller errors (12–17% vs 17–26%) in the top‐down inventories at 2° × 2.5° resolution. These errors in IFDMB‐derived emission estimates are amplified (53–62%) if compared to the assumed true emissions at 0.25° × 0.3125° resolution. When directly conducting inversions at 0.25° × 0.3125°, the IFDMB consistently exhibits larger errors (44–69% vs 30–45%) than the 4D‐Var approach. Analysis of simulated differences in NH3 columns and in NH3 emissions suggests stronger misalignments at the finer resolution, since the local column is more strongly influenced by spatial smearing from neighboring grids. Adjoint calculations indicate that the number of adjacent grids needed to account for most (>65%) of the emission contributions to the local columnar NH3 abundance over an NH3 source site increases from ~1 at 2° × 2.5° to ~10 at 0.25° × 0.3125°, leading to increased errors especially in IFDMB. Applying inversion results at 2° × 2.5° to update the a priori emissions at 0.25° × 0.3125° could improve the accuracy of IFDMB inversions and reduce the computational cost of 4D‐Var.
Kidney Transplantation and Gender Disparity

Gender inequity in access to hemodialysis and kidney transplantation has created a public health crisis in the US. Women have a lower chance of receiving hemodialysis and kidney transplant than men, but they constitute the majority of living kidney donors. Research has shown that economic factors such as greater income of men may encourage females to be donors; while gender-bias on part of physicians or institutions, lack of social support networks and differences in health-seeking behaviors compared to men are cited as reasons for this imbalance. We suggest various strategies to improve participation of women in the transplant process by education; raising awareness by publishing gender-specific data for dialysis and transplant centers; education and workshops to eliminate gender-bias within institutions and health-care providers and establishment of gender-specific support groups. Transplant teams that are more sensitive to the social complexities of women’s lives may lead to increased understanding of the effects of renal disease and indicate measures that need to be in place in order to address this gender disparity in the treatment of renal failure. Research needs to be done to elucidate the underlying medical, societal or psychological processes that lead to gender bias in the field of kidney transplantation.
Signal waveform monitoring for power systems

This paper presents a novel approach on signal waveform monitoring for power systems. The monitoring of "real states" of power systems is critical for system secure operations and system restoration. This proposed approach monitors the "real states" of the systems and creates a new platform to achieve fast and accurate operation and control for power systems. A dynamic measurement unit (DMU) is also proposed to meet the requirements on data communications for high speed signal sampling. A simple test example is used to demonstrate the feasibility of implementing the proposed approach.
Genetic characterization of the Neotropical catfish Pimelodus maculatus (Pimelodidae, Siluriformes) in the Upper Uruguay River

Freshwater fish present unique challenges when one attempts to understand the factors that determine the structure of their populations. Habitat fragmentation is a leading cause of population decline that threatens ecosystems worldwide. In this study, we investigated the conservation status of genetic variability in the Neotropical catfish (Pimelodus maculatus). Specifically, we examined the structure and genetic diversity of this species in a region of the Upper Uruguay River fragmented by natural barriers and dams. There was no genetic structure among the four sites analyzed, indicating the existence of only one population group. A combination of environmental management and genetic monitoring should be used to minimize the impact of impoundment on panmitic populations of migratory fish species.
Fas or ceramide induce apoptosis by Ras‐regulated phosphoinositide‐3‐kinase activation

We demonstrate a rapid and transient activation of phosphoinositide‐3‐kinase (PI‐3‐K) by Fas receptor triggering or cellular treatment with synthetic C6‐ceramide. The stimulation of PI‐3‐K is critical for Fas or C6‐ceramide‐induced programmed cell death because transfection with a transdominant inhibitory PI‐3‐K construct or pretreatment with the PI‐3‐K inhibitor wortmannin almost completely prevented Fas or C6‐ceramide‐mediated apoptosis. Treatment with the caspase inhibitor Ac‐YVAD‐cmk or cellular transfection with transdominant inhibitory N17Ras prevented PI‐3‐K stimulation by Fas, suggesting that Fas activates PI‐3‐K via caspases and Ras. N17Ras expression also prevented C6‐ceramide‐initiated PI‐3‐K stimulation. The notion of a PI‐3‐K regulation by Ras upon Fas receptor ligation or ceramide treatment is supported by co‐immunoprecipitation experiments revealing an activation‐dependent association of PI‐3‐K and Ras. J. Leukoc. Biol. 63: 253–263; 1998.
Weighted Bloom filter

A Bloom filter is a simple randomized data structure that answers membership query with no false negative and a small false positive probability. It is an elegant data compression technique for membership information and has broad applications. In this paper, we generalize the traditional Bloom filter to weighted Bloom filter, which incorporates the information on the query frequencies and the membership likelihood of the elements into its optimal design. It has been widely observed that in many applications, some popular elements are queried much more often than the others. The traditional Bloom filter for data sets with irregular query patterns and non-uniform membership likelihood can be further optimized. We derive the optimal configuration of the Bloom filter with query-frequency and membership-likelihood information, and show that the adapted Bloom filter always outperforms the traditional Bloom filter. Under reasonable frequency models such as the step distribution or the Zipf's distribution, the improvement of the false positive probability of the weighted Bloom filter over that of the traditional Bloom filter has been evaluated by simulations
Serum 25-hydroxyvitamin D and parathyroid hormone are independent determinants of whole-body insulin sensitivity in women and may contribute to lower insulin sensitivity in African Americans.

BACKGROUND Circulating 25-hydroxyvitamin D [25(OH)D] and parathyroid hormone (PTH) concentrations have been shown to be associated with insulin sensitivity; however, adiposity may confound this relation. Furthermore, African Americans (AAs) have lower insulin sensitivity and 25(OH)D concentrations than do European Americans (EAs); whether these differences are associated in a cause-and-effect manner has not been determined. OBJECTIVES The objectives of this study were to examine the relation of 25(OH)D and PTH concentrations with whole-body insulin sensitivity and to determine whether lower 25(OH)D concentrations in AAs compared with EAs contribute to the lower insulin sensitivity of AAs relative to that of EAs. DESIGN This was a cross-sectional study of 25 AA and 25 EA women. We determined the whole-body insulin sensitivity index (S(I)) with an intravenous glucose tolerance test and minimal modeling. Percentage body fat was determined with dual-energy X-ray absorptiometry, and intraabdominal adipose tissue (IAAT) was determined with computed tomography. RESULTS Multiple linear regression analysis indicated that 25(OH)D and PTH concentrations were independent determinants of S(I) [standardized β = 0.24 (P = 0.04) and -0.36 (P = 0.002), respectively] after adjustment for age, race, and IAAT. The mean ethnic difference in S(I) decreased from 2.70 [· 10(-4) · min⁻¹/(μIU/mL)] after adjustment for IAAT and percentage body fat to 1.80 [· 10(-4) · min⁻¹/(μIU/mL)] after further adjustment for 25(OH)D and PTH concentrations. CONCLUSIONS 25(OH)D and PTH concentrations were independently associated with whole-body insulin sensitivity in a cohort of healthy women, which suggested that these variables may influence insulin sensitivity through independent mechanisms. Furthermore, ethnic differences in 25(OH)D concentrations may contribute to ethnic differences in insulin sensitivity.
Segmental hair analysis for differentiation of tilidine intake from external contamination using LC-ESI-MS/MS and MALDI-MS/MS imaging.

Segmental hair analysis has been used for monitoring changes of consumption habit of drugs. Contamination from the environment or sweat might cause interpretative problems. For this reason, hair analysis results were compared in hair samples taken 24 h and 30 days after a single tilidine dose. The 24-h hair samples already showed high concentrations of tilidine and nortilidine. Analysis of wash water from sample preparation confirmed external contamination by sweat as reason. The 30-day hair samples were still positive for tilidine in all segments. Negative wash-water analysis proved incorporation from sweat into the hair matrix. Interpretation of a forensic case was requested where two children had been administered tilidine by their nanny and tilidine/nortilidine had been detected in all hair segments, possibly indicating multiple applications. Taking into consideration the results of the present study and of MALDI-MS imaging, a single application as cause for analytical results could no longer be excluded. Interpretation of consumption behaviour of tilidine based on segmental hair analysis has to be done with caution, even after typical wash procedures during sample preparation. External sweat contamination followed by incorporation into the hair matrix can mimic chronic intake. For assessment of external contamination, hair samples should not only be collected several weeks but also one to a few days after intake. MALDI-MS imaging of single hair can be a complementary tool for interpretation. Limitations for interpretation of segmental hair analysis shown here might also be applicable to drugs with comparable physicochemical and pharmacokinetic properties.