Miracle-dz/UniFAR-FTUs huggingface dataset:
Lipectomy of the Ilio-Lumbosacral Region

In the past, several techniques for raising the gluteal mass have been described, all of which were based on dermolipectomies of major or minor extension. The main disadvantage of these dermolipectomies is the visible external scar. The author presents his technique for lipectomy of the ilio-lumbosacral region. It is proposed that multiplanar liposuction in this region lengthens the lumbar lordotic curve and results in upward traction on the buttocks, resulting in a more youthful contour of the region. The article describes a series of 98 patients with lipodystrophy of the ilio-lumbosacral area who underwent liposuction of the region and were highly satisfied with the results.
Instance memorization and category influence: Challenging the evidence for multiple systems in category learning

A class of dual-system theories of categorization assumes a categorization system based on actively formed prototypes in addition to a separate instance memory system. It has been suggested that, because they have used poorly differentiated category structures (such as the influential “5-4” structure), studies supporting the alternative exemplar theory reveal little about the properties of the categorization system. Dual-system theories assume that the instance memory system only influences categorization behaviour via similarity to single isolated instances, without generalization across instances. However, we present the results of two experiments employing the 5-4 structure to argue against this. Experiment 1 contrasted learning in the standard 5-4 structure with learning in an even more poorly differentiated 5-4 structure. In Experiment 2, participants memorized the 5-4 structure based on a five minute simultaneous presentation of all nine category instances. Both experiments revealed category influences as reflected by differences in instance learnability and generalization, at variance with the dual-system prediction. These results have implications for the exemplars versus prototypes debate and the nature of human categorization mechanisms.
Class-Size Effects in School Systems Around the World: Evidence from Between-Grade Variation in Timss

We estimate the effect of class size on student performance in 11 countries, combining school fixed effects and instrumental variables to identify random class-size variation between two adjacent grades within individual schools. Conventional estimates of class-size effects are shown to be severely biased by the non-random placement of students between and within schools. While we find sizable beneficial effects of smaller classes in Greece and Iceland, we reject the possibility of even small effects in four countries and of large beneficial effects in an additional four countries. Noteworthy class-size effects are observed only in countries with relatively low teacher salaries.
Manipulating anthropomorphic inferences about NAO: The role of situational and dispositional aspects of effectance motivation

In an experiment we empirically tested one key determinant of Epley's Three-Factor Theory of Anthropomorphism: Specifically, we investigated the interplay of both dispositional and situational facets of effectance motivation in predicting anthropomorphic inferences about the robot NAO. That is, we manipulated the predictability of the robot's behavior and whether participants anticipated an interaction with NAO. Innovatively, we also examined interindividual differences in participants' desire for control, a dispositional aspect of effectance motivation. Taken together, we go beyond previous work by (1) increasing ecological validity of the experimental setting; by (2) extending the range of measures to assess anthropomorphism, and by (3) examining the role of contextual and dispositional components of effectance motivation for anthropomorphism. Because this is the first work to study the interplay between these factors, our work contributes to a better theoretical and empirical understanding of psychological anthropomorphism.
Effects of stitch classes on the electrical properties of conductive threads

Bio-physical signal measurement tools embedded in clothing are becoming a viable alternative in mobile health monitoring systems, particularly Wearable Electronic Textile-based Systems (WETS). To assure clinical viability, utilizing flexible and inconspicuous conductive media that can acquire and transmit reliable signals while assuring signal durability and biocompatibility are particularly important when developing WETS for medical applications. To accomplish this task, conductive threads are emerging as an appropriate electrical medium for health monitoring garments. However, little has been studied on the behavior of these conductive threads under various conditions. We report here the electrical conductive properties of specific conductive threads under two conditions: (i) as sewn configurations onto a textile substrate with different stitch types and (ii) as independent strands under controlled extension independent from a sewing machine. Statistical results showed that the stitch class and thread location significantly influenced the electrical resistance of the conductive thread, revealing the chain stitch to provide resistance even lower than the un-stitched conductive thread. In addition, under controlled extension all three of the conductive threads exhibited both a hysteresis and a stress-relaxation effect. These are important phenomena to examine when conductive threads are incorporated into WETS because the choice of stitch type will influence the strength of the signals received and transmitted, while the wearers’ body movements will cause the threads to encounter multi-axial stretch. Knowing the influence of stitch type, stretch, and relaxation on conductive thread resistance will inform objective design and manufacturing decisions for developing clinical-grade textile-based electrical circuits for medical applications.
A single-cell spiking model for the origin of grid-cell patterns

Spatial cognition in mammals is thought to rely on the activity of grid cells in the entorhinal cortex, yet the fundamental principles underlying the origin of grid-cell firing are still debated. Grid-like patterns could emerge via Hebbian learning and neuronal adaptation, but current computational models remained too abstract to allow direct confrontation with experimental data. Here, we propose a single-cell spiking model that generates grid firing fields via spike-rate adaptation and spike-timing dependent plasticity. Through rigorous mathematical analysis applicable in the linear limit, we quantitatively predict the requirements for grid-pattern formation, and we establish a direct link to classical pattern-forming systems of the Turing type. Our study lays the groundwork for biophysically-realistic models of grid-cell activity.
Age- and Sex-Related Differences in Force-Velocity Characteristics of Upper and Lower Limbs of Competitive Adolescent Swimmers

Age- and Sex-Related Differences in Force-Velocity Characteristics of Upper and Lower Limbs of Competitive Adolescent Swimmers While there is a direct relationship between maximal anaerobic power (Pmax) and swimming performance, the relationship between upper and lower limbs with regard to Pmax and force-velocity (F-v) characteristics is not clear. The aim of the present study was to examine the effect of age and sex on the ratios of mechanical characteristics between upper and lower extremities of adolescent swimmers. Seventeen girls (aged 14.7±1.8 yr) (mean±standard deviation) and 28 boys (14.6±1.4 yr), all members of competitive swimming clubs, performed a F-v test for both legs and arms. In legs, boys had higher values of Pmax (t43=2.4, p<0.05), Pmax expressed in relative to body mass values (rPmax, t43=3.4, p<0.01) and v0 (t43=4.3, p<0.001), while no differences were found for F0 (t43=1.0, p=0.31) and v0/F0 (t43=0.55, p=0.59). In arms, boys had higher values of Pmax (t43=3.2, p<0.01), rPmax (t43=3.9, p<0.001) and v0 (t43=3.4, p<0.01), while no differences were found for F0 (t43=1.9, p=0.06) and v0/F0 (t43=0.16, p=0.87). However, no sex difference was found with regard to the ratios of Pmax (t43=1.9, p=0.06), F0 (t43=1.2, p=0.23) and v0 (t43=1.3, p=0.20) between upper and lower extremities. There was direct relationship between age and Pmax of legs (r=0.64, p<0.01 in girls; r=0.43, p<0.05 in boys) and arms (r=0.56, p<0.05; r=0.57, p<0.01 respectively), while there was not any significant association between age and the ratios of mechanical characteristics of upper and lower limbs. These findings emphasize the need for separate evaluation of arms' and legs' force-velocity characteristics on a regular basis and the consideration of these measures in training design.
Entry of Neisseria meningitidis into Mammalian Cells Requires the Src Family Protein Tyrosine Kinases

ABSTRACT Neisseria meningitidis, the causative agent of meningitis and septicemia, is able to attach to and invade a variety of cell types. In a previous study we showed that entry of N. meningitidis into human brain microvascular endothelial cells (HBMEC) is mediated by fibronectin bound to the outer membrane protein Opc, which forms a molecular bridge to α5β1-integrins. This interaction results in cytoskeletal remodeling and uptake of the bacteria. In this study we identified and characterized the intracellular signals involved in integrin-initiated uptake of N. meningitidis. We determined that the Src protein tyrosine kinases (PTKs) are activated in response to contact with N. meningitidis. Inhibition of Src PTK activity by the general tyrosine kinase inhibitor genistein and the specific Src inhibitor PP2 reduced Opc-mediated invasion of HBMEC and human embryonic kidney (HEK) 293T cells up to 90%. Moreover, overexpression of the cellular Src antagonist C-terminal Src kinase (CSK) also significantly reduced N. meningitidis invasion. Src PTK-deficient fibroblasts were impaired in the ability to internalize N. meningitidis and showed reduced phosphorylation of the cytoskeleton and decreased development of stress fibers. These data indicate that the Src family PTKs, particularly the Src protein, along with other proteins, are important signal proteins that are responsible for the transfer of signals from activated integrins to the cytoskeleton and thus mediate the endocytosis of N. meningitidis into brain endothelial cells.
Perinatal Mortality in Multiple Pregnancy

Twins and higher–order multiple pregnancies account for approximately 3% of all gestations in the United States (Ananth et al, 2004) and seem to be stabilized since 2006 after a dramatically increase since the beginning of the 1970s (Vayssiere et al, 2011). There are two main causes for the change in the rate of multiple pregnancies: advanced maternal age and use of assisted reproductive techniques (ART) (Chauhan et al, 2010).
Why That Nao?: How Humans Adapt to a Conventional Humanoid Robot in Taking Turns-at-Talk

This paper explores how humans adapt to a conventional humanoid robot. Video data of participants playing a charade game with a Nao robot were analyzed from a multimodal conversation analysis perspective. Participants soon adjust aspects of turn-design such as word selection, turn length and prosody, thereby adapting to the robot's limited perceptive abilities as they become apparent in the interaction. However, coordination of turns-at-talk remains troublesome throughout the encounter, as evidenced by overlapping turns and lengthy silences around possible turn endings. The study discusses how the robot design can be improved to support the problematic taking of turns-at-talk with humans. Two programming strategies to address the identified problems are presented: 1. to program the robot so that it will be systematically receptive at the equivalence to transition relevance places in human-human interaction, and 2. to make the robot preferably produce verbal actions that require a response in a conditional way, rather than making a response only possible.
Throughput and delay analysis for the IEEE 802.11e enhanced distributed channel access

In this letter, we propose a three-dimensional Markov chain model for the 802.11e enhanced distributed channel access (EDCA) mode. This model can be used to compute the maximum sustainable throughput and service delay distribution for each priority class when under saturation load. The new framework models the performance impact of major quality-of-service (QoS)-specific features (e.g., CWMin, CWMax, AIFS, internal collision resolution) of the 802.11e EDCA mode, and hence can provide an analytical approach to pick the parameter values associated with EDCA to meet the QoS requirements of each priority.
Once-daily fluticasone furoate (FF)/vilanterol reduces risk of severe exacerbations in asthma versus FF alone

Background Combination therapy with an inhaled corticosteroid (ICS) and long-acting β2 agonist (LABA) is recommended for patients with asthma symptomatic on ICS alone. However, there is ongoing debate regarding the risk-benefit ratio of using LABA in asthma. Objective To evaluate the effect of the addition of a novel LABA, vilanterol (VI), to a once-daily ICS, fluticasone furoate (FF), on the risk of severe asthma exacerbations in patients with uncontrolled asthma. Methods This randomised double-blind comparative study of variable duration (≥24–78 weeks) was designed to finish after 330 events (each patient's first on-treatment severe asthma exacerbation). 2019 patients with asthma aged ≥12 years with ≥1 recorded exacerbation within 1 year were randomised and received FF/VI 100/25 μg or FF 100 μg, administered once daily in the evening. The primary endpoint was time to first severe exacerbation; secondary endpoints were rate of severe asthma exacerbations per patient per year and change in trough evening forced expiratory volume in 1 s (FEV1) from baseline. Results Compared with FF, FF/VI delayed the time to first severe exacerbation (HR 0.795, 95% CI 0.642 to 0.985) and reduced the annualised rate of severe exacerbations (rate reduction 25%, 95% CI 5% to 40%). Significantly greater improvements in trough FEV1 (p<0.001) were observed with FF/VI than with FF at weeks 12, 36, 52 and at endpoint. Both treatments were well tolerated with similar rates of treatment-related adverse events and on-treatment serious adverse events. Conclusions Once-daily FF/VI reduced the risk of severe asthma exacerbations and improved lung function compared with FF alone, with good tolerability and safety profile in adolescents and adults with asthma currently receiving ICS. ClinicalTrials.gov No NCT01086384
The effect of intracellular pH on ATP‐dependent potassium channels of frog skeletal muscle.

1. We have used patch‐clamp methods to study the effects of pH at the cytoplasmic surface of the membrane on ATP‐dependent K+ channels (KATP channels) in patches excised from frog (Rana temporaria) skeletal muscle, and to study the kinetics of ATP binding. 2. In the absence of ATP, a reduction in pH led to a slight decrease in single‐channel current amplitude, an increase in the number of very brief closings, an increase in the apparent mean open time, and an increase in burst duration. After correction for missed closings, the change in mean open time was slight. Despite these changes in detailed kinetics, the channel open‐state probability, Popen, changed little with changes in pH in the absence of ATP. 3. In the presence of ATP, a decrease in internal pH (pHi) reduced the degree of channel inhibition by ATP, shifting the curve relating Popen and [ATP] to higher concentrations of ATP without altering its steepness. The ATP concentration for half‐inhibition of channel activity (Ki) was 17 microM at pH 7.2 and 260 microM at pH 6.3. 4. The effect of pH could be modelled by assuming that one or two protons bind to the channel and prevent ATP binding to exert its effect of causing channel closure. The predicted dissociation constants for ATP and H+ respectively were 5.4 and 0.11 microM. 5. The rate constants for binding and unbinding of ATP were estimated from the dependence of the mean open time on [ATP] and from the Ki. The apparent rate constants for ATP binding were 0.6 and 0.04 mM‐1 ms‐1 at pH 7.2 and 6.3 respectively, while the rate constant for unbinding was 0.01 ms‐1. In terms of our model the calculated true rate constant for ATP binding was 1.85 mM‐1 ms‐1. ATP binding also led to a reduction in burst duration. 6. The effect of pH described here differs from findings in cardiac muscle and pancreatic B‐cells. The results are discussed in relation to the possible function of KATP channels in skeletal muscle during exercise.
Testing database applications using coverage analysis and mutation analysis

ix CHAPTER 1. SOFTWARE TESTING FOR DATABASE APPLICATIONS 1 1.1 Background . 1 1.2 Driving Problem . 6 1.3 Our Solution . 7 1.4 Overall Contributions . 9 1.5 Organization . 10 CHAPTER 2. RELATED WORK . 11 2.1 Automated Test Case Generation . 12 2.2 Mutation Testing . 15 2.3 Database Application Testing . 17 CHAPTER 3. ConSMutate: SQL MUTANTS FOR GUIDING CONCOLIC TESTING OF DATABASE APPLICATIONS . 19 3.
Recovery Sleep Reverses Impaired Response Inhibition due to Sleep Restriction: Evidence from a Visual Event Related Potentials Study

Objective To investigate response inhibition after total sleep deprivation (TSD) and the restorative effects of one night of recovery sleep (RS). Methods Fourteen healthy male participants performed a visual Go/NoGo task, and electroencephalogram recordings were conducted at five time points: (1) baseline, (2) after 12 h of TSD, (3) after 24 h of TSD, (4) after 36 h of TSD, and (5) following 8 h of RS. The dynamic changes in response inhibition during TSD and after 8 h of RS were investigated by examining the NoGo-N2 and NoGo-P3 event-related potential components. Results Compared with baseline, NoGo-P3 amplitudes were decreased, while the NoGo-N2 latency increased along with the awake time prolonged. NoGo anteriorization, which was minimized after 24 h of TSD, progressively decreased with increasing TSD. After 8 h of RS, recoveries of both the NoGo-P3 amplitude and NoGo-N2 latency in the prefrontal cortex were observed compared with the values after 36 h of TSD. Conclusion TSD induced a dose-dependent functional decline in the response inhibition of NoGo-N2 and NoGo-P3 on prefrontal cortex activation, and 8 h of RS resulted in recovery or maintenance of the response inhibition. However, it was not restored to baseline levels. Limitations Participants were chosen male college students only, thus the findings cannot be generalized to older people and women. Additionally, the sample size was small, and, thus, speculations on the meaning of the results of this study should be cautious. The EEG continuous recording should be employed to monitor the decline of alertness following TSD.
A Low-Power Current Mode Fuzzy-ART Cell

This paper presents a very large scale integration (VLSI) implementation of a low-power current-mode fuzzy-adaptive resonance theory (ART) cell. The cell is based on a compact new current source multibit memory cell with online learning capability. A small prototype of the designed cell and its peripheral block has been fabricated in the AustriaMicroSystems (AMS)-0.35-mum technology. The cell occupies a total area of 44 times 34 mum2 and consumes a maximum current of 22 nA
Acute Kidney Injury by Radiographic Contrast Media: Pathogenesis and Prevention

It is well known that iodinated radiographic contrast media may cause kidney dysfunction, particularly in patients with preexisting renal impairment associated with diabetes. This dysfunction, when severe, will cause acute renal failure (ARF). We may define contrast-induced Acute Kidney Injury (AKI) as ARF occurring within 24–72 hrs after the intravascular injection of iodinated radiographic contrast media that cannot be attributed to other causes. The mechanisms underlying contrast media nephrotoxicity have not been fully elucidated and may be due to several factors, including renal ischaemia, particularly in the renal medulla, the formation of reactive oxygen species (ROS), reduction of nitric oxide (NO) production, and tubular epithelial and vascular endothelial injury. However, contrast-induced AKI can be prevented, but in order to do so, we need to know the risk factors. We have reviewed the risk factors for contrast-induced AKI and measures for its prevention, providing a long list of references enabling readers to deeply evaluate them both.
An empirical model of customer loyalty in the Jordanian Mobile Telecommunications Market

The purpose of this research was to empirically examine a model of customer loyalty antecedents in the context of Jordanian Mobile Telecommunications Market (JMTM). A structured questionnaire was distributed to a sample of 1000 mobile subscribers in JMTM from which 756 were valid for the analysis. Structural path analysis empirical findings underlined that customer loyalty in JMTM is a multi-dependent concept affected, respectively, by customer satisfaction, trust, perceived switching costs and perceived service quality. In addition to being the first study of its kind in Jordan, the paper's contribution stems from fulfilling the research gap in examining the simultaneous effect of perceived service quality, customer satisfaction, trust and perceived switching costs on customer loyalty.
Pulmonary Regurgitation Is an Important Determinant of Right Ventricular Contractile Dysfunction in Patients With Surgically Repaired Tetralogy of Fallot

Background—Evaluation of right ventricular (RV) function in patients with pulmonary regurgitation (PR) after tetralogy repair remains challenging because of abnormal RV loading conditions. Methods and Results—We examined 124 patients, aged 21±11.4 years, who had tetralogy repair at 3.7±3.5 years. By Doppler echocardiography, 33 patients had mild, 22 moderate, and 69 severe PR; 55 had significant tricuspid regurgitation (TR). Myocardial velocities, myocardial acceleration during isovolumic contraction (IVA), strain, and strain rate were measured at RV and LV base. Tricuspid valve annulus was measured in a 4-chamber view. QRS, QT, and JT intervals and their dispersions were measured from 12-lead electrocardiogram. IVA in the RV was lower in all patients compared with controls (0.8±0.4 versus 1.8±0.5, P<0.0001) and correlated with the severity of PR (r=−0.43, P<0.0001), whereas myocardial velocities, and strain/strain rate did not. LV IVA correlated with PR (r=−0.32, P<0.001) and with RV IVA (r=0.28, P<0.003). Patients with severe PR had a higher incidence of TR (r=0.69, P<0.0001) and lower RV IVA (1.0±0.4 versus 0.6±0.3, P<0.0001), a larger tricuspid valve ring diameter (P<0.0001), and prolonged electrical depolarization (P<0.001). Age at surgery or examination did not correlate with PR and with RV function assessed by IVA. In the RV, IVA correlated inversely with QRS duration (P<0.01). Conclusions—Although load-dependent myocardial velocities and strain are not influenced by the severity of PR and presence of significant TR, IVA demonstrates reduced contractile function in relation to the degree of PR and may be an early, sensitive index for selecting patients for valve replacement.