Miracle-dz/UniFAR-FTUs huggingface dataset:
Can PET/CT Guide the Personalized Treatment of Patients with Gastroenteropancreatic Neuroendocrine Neoplasms?

Gastroenteropancreatic neuroendocrine neoplasms (GEPs) arise from the diffuse neuroendocrine system. Their incidence has markedly increased over the past 3 decades, probably as a result of the improvement in imaging and biochemical methods of detection (1). They are a heterogeneous group of neoplasms with varying clinical expressions, presenting as either functioning or nonfunctioning, with an indolent clinical course in most patients. Functioning tumors are commonly associated with a typical hormonal syndrome directly related to a hormone secreted by the neoplasm; nevertheless, patients may have symptoms for many years before the correct diagnosis is made, because symptoms are often nonspecific and can be due to hormonal excess, local tumor growth, or metastatic spread (2). Tumor grading and staging represent the main prognostic factors of these neoplasms. Apart from location, GEPs are graded according to proliferation activity, usually evaluated by the Ki67 index on tumor cells, which can have a strong impact on prognosis and therapy (3). The well-differentiated neoplasms, regardless of their benign or malignant behavior, are named neuroendocrine
Coded Modulation for Power Line Communications

We discuss the application of coded modulation for power-line communications. We combine M-ary FSK with diversity and coding to make the transmission robust against permanent frequency disturbances and impulse noise. We give a particular example of the coding/modulation scheme that is in agreement with the existing CENELEC norms. The scheme can be considered as a form of coded Frequency Hopping and is thus extendable to any frequency range.
Risk analysis of ischemic‐type biliary lesions after liver transplant using octogenarian donors

HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés. Risk analysis of ischemic-type biliary lesions after liver transplant using octogenarian donors Michel Rayar, Giovanni Battista Levi Sandri, Caterina Cusumano, Pauline Houssel-Debry, Christophe Camus, Véronique Desfourneaux, Mohamed Lakehal, Bernard Meunier, Laurent Sulpice, Karim Boudjema
Hybrid Dysgenesis in DROSOPHILA MELANOGASTER: A Syndrome of Aberrant Traits Including Mutation, Sterility and Male Recombination.

A syndrome of associated aberrant traits is described in Drosophila melanogaster. Six of these traits, mutation, sterility, male recombination, transmission ratio distortion, chromosomal aberrations and local increases in female recombination, have previously been reported. A seventh trait, nondisjunction, is described for the first time. All of the traits we have examined are found nonreciprocally in F(1) hybrids. We present evidence that at least four of the traits are not found in nonhybrids. Therefore we have proposed the name hybrid dysgenesis to describe this syndrome. -A partition of tested strains into two types, designated P and M, was made according to the paternal or maternal contribution required to produce hybrid dysgenesis. This classification seems to hold for crosses of strains from within the United States and Australia, as well as for crosses between strains from the two countries. Strains collected recently from natural populations are typically of the P type and those having a long laboratory history are generally of the M type. However, a group of six strains collected from the wild in the 1960's are unambiguously divided equally between the P and M types. The dichotomy of this latter group raises interesting questions concerning possible implications for speciation. -Temperature often has a critical effect on the manifestation of hybrid dysgenesis. High F(1 ) developmental temperatures tend to increase the expression of sterility, sometimes to extreme levels. Conversely, low developmental temperatures tend to inhibit the expression of some dysgenic traits. -There are potentially important practical implications of hybrid dysgenesis for laboratory experimentation. The results suggest that care should be exercised in planning experiments involving strain crosses.
The effect of SMS messaging on the compliance with iron supplementation among pregnant women in Iran: a randomized controlled trial

We examined the effect of SMS text messages on compliance with iron supplementation among pregnant women. A randomized controlled trial was conducted on 116 pregnant women referred from public health centres in Ahvaz. Their gestational age was 14-16 weeks. The subjects were randomly assigned to a control group who received usual care, or to a 12-week intervention with SMS reminders in addition to usual care. Participants in both groups were provided with iron supplements and taught how to take iron tablets. Most women in the intervention group (94%) had high compliance with iron supplements compared to the control group (66%); this difference was significant (P = 0.003). Although haemoglobin, haematocrit and ferritin decreased significantly in each group, there was no significant difference between them. Using SMS reminders is an efficient way of improving compliance of women with iron supplementation during pregnancy. However, in the present study better compliance did not improve anaemia.
${\cal CPAS}$: An Efficient Conditional Privacy-Preserving Authentication Scheme for Vehicular Sensor Networks

In this paper, we propose a conditional privacy-preserving authentication scheme, called CPAS, using pseudo-identity-based signatures for secure vehicle-to-infrastructure communications in vehicular ad hoc networks. The scheme achieves conditional privacy preservation, in which each message launched by a vehicle is mapped to a distinct pseudo-identity, and a trust authority can always retrieve the real identity of a vehicle from any pseudo-identity. In the scheme, a roadside unit (RSU) can simultaneously verify multiple received signatures, thus considerably reducing the total verification time; an RSU can simultaneously verify 2540 signed-messages/s. The time for simultaneously verifying 800 signatures in our scheme can be reduced by 18%, compared with the previous scheme.
CMRS : ARCHITECTURE FOR CONTENT-BASED MULTIMEDIA RETRIEVAL

This paper presents a scalable and modular client-server architecture for contentbased multimedia retrieval. The proposed architecture is designed to facilitate straightfoward addition of new media types and retrieval operations without modifications to existing features. This is achieved by the encapsulation of data, operations and user interface related to a particular media data or query entity into a single component. The encapsulation allows us to divide the system into a media independent platform and modular media specific extensions, which provide knowledge and functionality related to a specific media type such as still image or video. The current implementation includes CBIR extension, which allows realization of complex content-based queries of images based on example images, sketched or predefined personalized semantic concepts with different color, texture and shape attributes. Various experiments are carried out to demonstrate the functionality of the architecture.
Democratizing Entry: Banking Deregulations, Financing Constraints, and Entrepreneurship

We examine entrepreneurship and creative destruction following US banking deregulations using Census Bureau data. US banking reforms brought about exceptional growth in both entrepreneurship and business closures. The vast majority of closures, however, were the new ventures themselves. Although we do find evidence for the standard story of creative destruction, the most pronounced impact was a massive increase in churning among new entrants. We argue that creative destruction requires many businesses failures along with the few great successes. The successes are very difficult to identify ex ante, which is why democratizing entry is an important trait of well-functioning capital markets.
Insulin resistance: a new consequence of altered carotid body chemoreflex?

Metabolic diseases affect millions of individuals across the world and represent a group of chronic diseases of very high prevalence and relatively low therapeutic success, making them suitable candidates for pathophysiological studies. The sympathetic nervous system (SNS) contributes to the regulation of energy balance and energy expenditure both in physiological and pathological states. For instance, drugs that stimulate sympathetic activity decrease food intake, increase resting metabolic rate and increase the thermogenic response to food, while pharmacological blockade of the SNS has opposite effects. Likewise, dysmetabolic features such as insulin resistance, dyslipidaemia and obesity are characterized by a basal overactivation of the SNS. Recently, a new line of research linking the SNS to metabolic diseases has emerged with the report that the carotid bodies (CBs) are involved in the development of insulin resistance. The CBs are arterial chemoreceptors that classically sense changes in arterial blood O2, CO2 and pH levels and whose activity is known to be increased in rodent models of insulin resistance. We have shown that selective bilateral resection of the nerve of the CB, the carotid sinus nerve (CSN), totally prevents diet‐induced insulin resistance, hyperglycaemia, dyslipidaemia, hypertension and sympathoadrenal overactivity. These results imply that the beneficial effects of CSN resection on insulin action and glucoregulation are modulated by target‐related efferent sympathetic nerves through a reflex that is initiated in the CBs. It also highlights modulation of CB activity as a putative future therapeutic intervention for metabolic diseases.
Brief Definitive Report Identification of a T3/t Cell Receptor Complex in Chickens

Closely associated with the antigen receptor molecule on the surface of human T cells is the T3 complex composed of two glycoproteins with Mr of 25,000 (3' chain) and 20,000 (~ chain), and a nonglycosylated protein of Mr 20,000 (E chain) (1, 2). Murine mAb have been made that recognize the human T3 molecule. Physical association of the T3 molecule with the T cell receptor (TCR) has been suggested by the ability of anti-T3 antibodies to coprecipitate a and/3 chains of the TCR (3, 4). mAb directed against either T3 or the TCR induce the same T cell activation signal (5, 6). Because of its importance in human T cell function, we anticipated that the T3/TCR complex would prove to be phylogenetically conserved. Recently (7-9), a murine T3 candidate has been identified by its coprecipitation with TCR and/3 chains. Here we report evidence indicating the existence of a functional T3/TCR complex in birds. Materials and Methods Lymphocyte Isolation and Immunofluorescence. Outbred white leghorn chickens, eggs, and young Indiana giant quails were obtained from local sources. Isolation of mononuclear cells from blood, thymus, bursa, spleen, and bone marrow, and immunofluorescent staining were as described (10, 11). The frequency of stained cells was analyzed by fluorescence microscopy or automated flow cytometry. Capping of lymphocyte surface molecules after immunofluorescent staining was evaluated after incubation of stained cells for 30 rain at 37°C. Preparation ofmAb CT-3. BALB/C mice were immunized by subcutaneous and footpad injections with chicken thymocytes and Ig-blood mononuclear cells, and their lymph node ceils were fused with P3-X63Ag8.653 myeloma cells (11). One resultant hybridoma produced an IgG1, antibody, CT-3, showing immunofluorescence reactivity with a sub-population of blood lymphocytes. The hybridoma was subcloned, grown in ascites, and the CT-3 antibody was purified on a protein A-Sepharose 4 B column. For mitogenicity studies, the purified CT-3 antibody was conjugated to Sepharose 4 B beads, and the exact amount of CT-3 bound to the beads calculated. Immunoprecipitation and Gel Electrophoresis. Blood mononuclear ceils were surface-labeled with NalZSl using the lactoperoxidase method, and lysed in either 1% NP-40 or 1% digitonin plus 0.2% NP-40 in 0.05 Tris, pH 7.5, containing protease inhibitors, at 4°C for 30 min (9, 10). Immunoisolation was performed in a microtiter plate by a solid
The mental health of deployed UK maritime forces

Objectives To establish the level of psychological symptoms and the risk factors for possible decreased mental health among deployed UK maritime forces. Methods A survey was completed by deployed Royal Navy (RN) personnel which measured the prevalence of common mental disorder (CMD), post-traumatic stress disorder (PTSD) and potential alcohol misuse. Military and operational characteristics were also measured including exposure to potentially traumatic events, problems occurring at home during the deployment, unit cohesion, leadership and morale. Associations between variables of interest were identified using binary logistic regression to generate ORs and 95% CIs adjusted for a range of potential confounding variables. Results In total, 41.2% (n=572/1387) of respondents reported probable CMD, 7.8% (n=109/1389) probable PTSD and 17.4% (n=242/1387) potentially harmful alcohol use. Lower morale, cohesion, leadership and problems at home were associated with CMD; lower morale, leadership, problems at home and exposure to potentially traumatic events were associated with probable PTSD; working in ships with a smaller crew size was associated with potentially harmful alcohol use. Conclusions CMD and PTSD were more frequently reported in the maritime environment than during recent land-based deployments. Rates of potentially harmful alcohol use have reduced but remain higher than the wider military. Experiencing problems at home and exposure to potentially traumatic events were associated with experiencing poorer mental health; higher morale, cohesion and better leadership with fewer psychological symptoms.
Agomelatine or placebo as adjunctive therapy to a mood stabiliser in bipolar I depression: Randomised double-blind placebo-controlled trial

Background Adjunctive antidepressant therapy is commonly used to treat acute bipolar depression but few studies have examined this strategy. Aims To examine the efficacy of agomelatine v. placebo as adjuncts to lithium or valproate in bipolar depression. Method Patients who were currently depressed despite taking lithium or valproate for at least 6 weeks were randomised to treatment with agomelatine (n = 172) or placebo (n = 172) for 8 weeks of acute therapy and 44 weeks of continuation therapy (trial registration: ISRCTN28588282). Results No significant differences in improvement of depressive symptoms were observed between the two groups either at 8 weeks or 52 weeks on the primary efficacy measure of change in Montgomery–Åsberg Depression Rating Scale scores from baseline to end-point. Adverse events including switches into mania/hypomania were low and similar in both groups. Conclusions Agomelatine adjunctive therapy was not superior to placebo adjunctive therapy for acute bipolar depression.
Cell adhesion in plants is under the control of putative O-fucosyltransferases

Cell-to-cell adhesion in plants is mediated by the cell wall and the presence of a pectin-rich middle lamella. However, we know very little about how the plant actually controls and maintains cell adhesion during growth and development and how it deals with the dynamic cell wall remodeling that takes place. Here we investigate the molecular mechanisms that control cell adhesion in plants. We carried out a genetic suppressor screen and a genetic analysis of cell adhesion-defective Arabidopsis thaliana mutants. We identified a genetic suppressor of a cell adhesion defect affecting a putative O-fucosyltransferase. Furthermore, we show that the state of cell adhesion is not directly linked with pectin content in the cell wall but instead is associated with altered pectin-related signaling. Our results suggest that cell adhesion is under the control of a feedback signal from the state of the pectin in the cell wall. Such a mechanism could be necessary for the control and maintenance of cell adhesion during growth and development. Highlighted article: Pectin-related signaling, rather than absolute pectin levels, are proposed to contribute to cell adhesion during growth and development in Arabidopsis thaliana.
Postchemotherapy MRI Overestimates Residual Disease Compared with Histopathology in Responders to Neoadjuvant Therapy for Locally Advanced Breast Cancer

The utility of breast magnetic resonance imaging in patients receiving neoadjuvant chemotherapy is not well defined. We compared serial magnetic resonance imaging examinations with histologic posttreatment examinations in patients treated with primary chemotherapy for locally advanced breast cancer. PATIENTS AND METHODSEligible patients with locally advanced breast cancer received doxorubicin 60 mg/m2 and docetaxel 60 mg/m2 (with granulocyte colony stimulating factor support) every 14 days for a maximum of six cycles. Breast magnetic resonance imaging was performed at baseline and repeated every two cycles. Surgery (either local excision or mastectomy) was performed after six cycles in responding or stable patients. Residual tumor size on pathology and preoperative magnetic resonance imaging was compared; concordance was defined as a < 0.5-cm difference. RESULTSTo date, three of 17 enrolled subjects (17.6%) attained pathologic complete response, and three additional patients attained near pathologic complete response, with residual foci of ≤ 1 mm. Of these six patients, only one was disease free by magnetic resonance imaging. Discordance between magnetic resonance imaging findings and pathologic evaluation was found in four of six patients (66.6%) who obtained pathologic complete response or near pathologic complete response. In the three patients in whom four axillary lesions were followed with magnetic resonance imaging, discordance was found in all four lesions, with magnetic resonance imaging overestimating pathologic disease in all cases. DISCUSSIONOur findings caution that magnetic resonance imaging may frequently overestimate residual invasive carcinoma after neoadjuvant chemotherapy. These results contradict previous studies suggesting that postchemotherapy magnetic resonance imaging may underestimate residual cancer. The use of magnetic resonance imaging in evaluating response to therapy in locally advanced breast cancer should be further studied.
Volume-regulated Anion Channels Serve as an Auto/Paracrine Nucleotide Release Pathway in Aortic Endothelial Cells

Mechanical stress induces auto/paracrine ATP release from various cell types, but the mechanisms underlying this release are not well understood. Here we show that the release of ATP induced by hypotonic stress (HTS) in bovine aortic endothelial cells (BAECs) occurs through volume-regulated anion channels (VRAC). Various VRAC inhibitors, such as glibenclamide, verapamil, tamoxifen, and fluoxetine, suppressed the HTS-induced release of ATP, as well as the concomitant Ca2+ oscillations and NO production. They did not, however, affect Ca2+ oscillations and NO production induced by exogenously applied ATP. Extracellular ATP inhibited VRAC currents in a voltage-dependent manner: block was absent at negative potentials and was manifest at positive potentials, but decreased at highly depolarized potentials. This phenomenon could be described with a “permeating blocker model,” in which ATP binds with an affinity of 1.0 ± 0.5 mM at 0 mV to a site at an electrical distance of 0.41 inside the channel. Bound ATP occludes the channel at moderate positive potentials, but permeates into the cytosol at more depolarized potentials. The triphosphate nucleotides UTP, GTP, and CTP, and the adenine nucleotide ADP, exerted a similar voltage-dependent inhibition of VRAC currents at submillimolar concentrations, which could also be described with this model. However, inhibition by ADP was less voltage sensitive, whereas adenosine did not affect VRAC currents, suggesting that the negative charges of the nucleotides are essential for their inhibitory action. The observation that high concentrations of extracellular ADP enhanced the outward component of the VRAC current in low Cl− hypotonic solution and shifted its reversal potential to negative potentials provides more direct evidence for the nucleotide permeability of VRAC. We conclude from these observations that VRAC is a nucleotide-permeable channel, which may serve as a pathway for HTS-induced ATP release in BAEC.
Depressive Symptoms in Extended-Care Employees: Children, Social Support, and Work-Family Conditions

To examine the relation between having a child aged 18 years and under in the home and employee depressive symptoms, we analyzed cross-sectional data from four extended care facilities in Boston, MA (n = 376 employees). Results show that having a child is associated with slightly higher depressive symptoms. The strength of this relationship in our models is attenuated with the inclusion of social support at home (β = 1.08 and β = 0.85, with and without support, respectively) and may differ by gender. We recommend that future research examine the role of parenting and social support in predicting employee mental health.
Application of Imagery Theory to Sport Psychology: Some Preliminary Findings

Bioinformational theory has been proposed by Lang (1979a), who suggests that mental images can be understood as products of the brain's information processing capacity. Imagery involves activation of a network of propositionally coded information stored in long-term memory. Propositions concerning physiological and behavioral responses provide a prototype for overt behavior. Processing of response information is associated with somatovisceral arousal. The theory has implications for imagery rehearsal in sport psychology and can account for a variety of findings in the mental practice literature. Hypotheses drawn from bioinformational theory were tested. College athletes imagined four scenes during which their heart rates were recorded. Subjects tended to show increases in heart rate when imagining scenes with which they had personal experience and which would involve cardiovascular activation if experienced in real life. Nonsignificant heart rate changes were found when the scene involved activation but w.
Modeling the importance of faces in natural images

In this work we study the varying importance of faces in images. Face importance is found to be affected by the size and number of faces present. We collected a dataset of 152 face images with faces in different size and number of faces. We conducted a crowdsourcing experiment where we asked people to label the important regions of the images. Analyzing the results from the experiment, we propose a simple face-importance model, which is a 2D Gaussian function, to quantitatively represent the influence of the size and number of faces on the perceived importance of faces. The face-importance model is then tested for the application of salient-object detection. For this application, we create a new salient-objects dataset, consisting of both face images and non-face images, and also through crowdsourcing we collect the ground truth. We demonstrate that our face-importance model helps us to better locate the important, thus salient, objects in the images and outperforms state-of-the-art salient-object detection algorithms.