Miracle-dz/UniFAR-FTUs huggingface dataset:
Relationships between the sarcoplasmic reticulum and sarcolemmal calcium transport revealed by rapidly cooling rabbit ventricular muscle

Rabbit right ventricular papillary muscles were cooled from 30 to approximately 1 degree C immediately after discontinuing electrical stimulation (0.5 Hz). This produced a contracture that was 30-50% of the preceding twitch magnitude and required 20-30 s to develop. The contractures were identical in cooling solutions with normal (144 mM) or low (2.0 mM) Na. They were therefore not Na-withdrawal contractures. Contracture activation was considerably slower than muscle cooling (approximately 2.5 s to cool below 2 degrees C). Cooling contractures were suppressed by caffeine treatment (10.0 mM). Rapid cooling did not cause sufficient membrane depolarization (16.5 +/- 1.2 mV after 30 s of cooling) to produce either a voltage-dependent activation of contracture or a gated entry of Ca from the extracellular space. Contractures induced by treating resting muscles with 5 X 10(-5) M strophanthidin at 30 degrees C exhibited pronounced tension noise. The Fourier spectrum of this noise revealed a periodic component (2-3 Hz) that disappeared when the muscle was cooled. Cooling contractures decayed with rest (t1/2 = 71.0 +/- 9.3 s). This decay accelerated in the presence of 10.0 mM caffeine and was prevented and to some extent reversed when extracellular Na was reduced to 2.0 mM. 20 min of rest resulted in a net decline in intracellular Ca content of 1.29 +/- 0.38 mmol/kg dry wt. I infer that cooling contractures are principally activated by Ca from the sarcoplasmic reticulum (SR). The properties of these contractures suggest that they may provide a convenient relative index of the availability of SR Ca for contraction. The rest decay of cooling contractures (and hence the decay in the availability of activating Ca) is consistent with the measured loss in analytic Ca during rest. The results suggest that contraction in heart muscle can be regulated by an interaction between sarcolemmal and SR Ca transport.
Production of consonants by prelinguistically deaf children with cochlear implants

Consonant production following the sensory restoration of audition was investigated in 22 prelinguistically deaf French children who received cochlear implants. Spontaneous speech productions were recorded at 6, 12, and 18 months post‐surgery and consonant inventories were derived from both glossable and non‐glossable phones using two acquisition criteria. The results showed that children initiated appropriate production of consonants after six months of implant use. Stops and labials were the most frequently produced speech sounds, whereas glides and palatals were still infrequent after 18 months. Speech accuracy also improved throughout the study. Consonant visibility appeared to influence the order of acquisition in the first months following the implantation and, as experience with auditory information increased, patterns of development tended to resemble those seen in children with normal hearing. Finally, a signed mode of communication and oral rehabilitation programs prior to implantation were better outcome predictors than age at implantation.
About Merging Threshold and Critical Flux Concepts into a Single One: The Boundary Flux

In the last decades much effort was put in understanding fouling phenomena on membranes. One successful approach to describe fouling issues on membranes is the critical flux theory. The possibility to measure a maximum value of the permeate flux for a given system without incurring in fouling issues was a breakthrough in membrane process design. However, in many cases critical fluxes were found to be very low, lower than the economic feasibility of the process. The knowledge of the critical flux value must be therefore considered as a good starting point for process design. In the last years, a new concept was introduced, the threshold flux, which defines the maximum permeate flow rate characterized by a low constant fouling rate regime. This concept, more than the critical flux, is a new practical tool for membrane process designers. In this paper a brief review on critical and threshold flux will be reported and analyzed. And since the concepts share many common aspects, merged into a new concept, called the boundary flux, the validation will occur by the analysis of previously collected data by the authors, during the treatment of olive vegetation wastewater by ultrafiltration and nanofiltration membranes.
Cervical smear: is screening of teenagers justified?

The computer data base identi® ed 3377 smears taken from 2750 women between 1 July 1994 and 31 December 1996. The age range of women at the time of their smears was 13 to 65 years (mean 24.9, median 22). Twenty-seven per cent (921) of the smears were from those under the age of 20. Smear results were compared between those under and those over the age of 20 as shown in Table 1. It was evident that the frequency of moderate or severe dyskaryosis amongst those under 20 was signi® cantly lower (c=4.4; P=0.036). Of the women under the age of 20 who had moderate or severe dyskaryosis, 5 were shown to have cervical intraepithelial neoplasia, CIN 1 and 2 CIN 2 after colposcopic biopsy. Patients, 27.4% (17/62), with mild abnormalities under the age of 20 compared with 15.5% (20/129) of those above 20 with similar abnormalities defaulted.
Trajectories, Antecedents, and Outcomes of Childhood Somatization in School-Age Boys

The current study had three goals that were designed to extend our understanding of childhood somatization (SOM). The first goal was to use a group-based trajectory analysis to plot developmental pathways of SOM. The second goal was to use a developmental psychopathology framework to identify risk factors from multiple domains that discriminated SOM trajectories. The third and final goal was to examine the relationship between child maladjustment, including functional impairment, and SOM trajectory group status. These goals were conducted with a sample of 310 ethnically diverse, low-income boys followed longitudinally from ages 2 to 12, using multiple methods and informants. Similar to research using broadly-defined internalizing behaviors, three developmental trajectories were identified: No, Low Increasing, and Moderate Increasing. The majority of the boys (i.e., 82%) were reported as displaying at least low to moderate levels of SOM across childhood. In addition to these three trajectories, a small group of boys (n = 5) demonstrated a distinct pattern of SOM, called the Moderate to High (MTH) group. Follow-up analyses indicated that the Moderate Increasing group was differentiated from the No group by higher levels of maternal depressive symptoms and parent-child conflict, whereas the MTH group demonstrated lower levels of social skills than the other three groups. Higher levels of both child negative affectivity and parent-child conflict discriminated the Low Increasing group from the No group. Differences in child outcomes at ages 11 and 12 were not found. The implications of the results for clinical intervention and future research are discussed.
Industrial Perspective on Deep Brain Stimulation: History, Current State, and Future Developments

Deep brain stimulation (DBS) emerged in the late 1960s as a possible therapeutic alternative to lesioning in patients with severe, chronic, intractable pain. DBS devices in the era were based on cardiac pacing technology but were greatly modified in implementation due to the unique needs of DBS. Clinical studies in the 1970s and early 1980s have revealed a technique with modest results which did not lead to regulatory approval for the treatment of pain. In the 1980s a new application for DBS emerged in the treatment of movement disorders. Clinical trials confirmed the robustness of the therapy leading to approvals by regulatory authorities in the US and Europe for the treatment of tremor and the symptoms of Parkinson’s disease. Technology based on that used for earlier clinical research in pain was improved by leveraging advances in cardiac pacing technology resulting in the sophisticated and reliable systems available today. In the 1990s scientific exploration began in the treatment of psychiatric disorders which is ongoing today. Simultaneously, studies into the treatment of epilepsy were begun which resulted in regulatory approval in Europe. Suggestions have been made to expand these scientific explorations to other central nervous system dysfunctions. Opportunity remains to improve the technology including individualized and symptom specific stimulation patterns, more physician and patient friendly programming, and possibly closed-loop systems for more situation dependent and effective therapy.
The Nature of creativity : contemporary psychological perspectives

Preface List of contributors Introduction Part I. The Role of the Environment in Creativity: 1. The conditions of creativity Beth A. Hennessey and Teresa M. Amabile Part II. The Role of the Individual in Creativity Section 1. Psychometric Approaches: 2. The nature of creativity as manifest in its testing E. Paul Torrance 3. Putting creativity to work Frank Barron 4. Various approaches to and definitions of creativity Calvin W. Taylor Section 2. Cognitive Approaches: 5. A three-facet model of creativity Robert J. Sternberg 6. Problem solving and creativity Robert W. Weisberg 7. A computational model of scientific insight Pat Langley and Randolph Jones 8. Freedom and constraint in creativity Philip N. Johnson-Laird 9. Creativity as a mechanical process Roger C. Schank Part III. The Role of the Individual-Environment Interaction in Creativity Section 1. The Study of Creative Lives: 10. Inching our way up Mount Olympus: the evolving-systems approach to creative thinking Howard E. Gruber and Sara N. Davis 11. Creativity: dreams, insights and transformations David Henry Feldman 12. Creative lines and creative works: a synthetic scientific approach Howard Gardener Section 2. The Study of Creative Systems: 13. Society, culture, and person: a systems view of creativity Mihaly Csikszentmihalyi 14. Creativity and talent as learning Herbert J. Walberg 15. The possibility of invention D. N. Perkins 16. Creativity, leadership, and chance Dean Keith Simonton Part IV. Integration and Conclusion: 17. What do we know about creativity? Twila Z. Tardiff and Robert J. Sternberg Author index Subject index.
Human-Induced Changes in the Hydrology of the Western United States

Observations have shown that the hydrological cycle of the western United States changed significantly over the last half of the 20th century. We present a regional, multivariable climate change detection and attribution study, using a high-resolution hydrologic model forced by global climate models, focusing on the changes that have already affected this primarily arid region with a large and growing population. The results show that up to 60% of the climate-related trends of river flow, winter air temperature, and snow pack between 1950 and 1999 are human-induced. These results are robust to perturbation of study variates and methods. They portend, in conjunction with previous work, a coming crisis in water supply for the western United States.
Outpatient antibiotic prescriptions from 1992 to 2001 in the Netherlands.

OBJECTIVES Although Dutch outpatient antibiotic prescription rates are low compared with other European countries, continuing to scrutinize trends in outpatient antibiotic use is important in order to identify possible increases in antibiotic use or inappropriate increases in the use of particular classes of antibiotics. METHODS We assessed the volume of Dutch outpatient antibiotic prescriptions from 1992 to 2001 by calculating the mean number of outpatient antibiotic prescriptions (indicating the number of times physicians decide to prescribe an antibiotic agent) per 1000 patients insured by the Dutch Sickness Fund per year, according to subgroups (narrow-spectrum penicillins, broad-spectrum penicillins, tetracyclines, macrolides, sulphonamides and trimethoprim, and quinolones). Data were obtained from the Dutch Drug Information Project/Health Care Insurance Board. RESULTS The total volume of outpatient antibiotic prescriptions in 2001 was 394 prescriptions per 1000 patients insured by the Dutch Sickness Fund. Overall, the rates were stable between 1992 and 2001, with small variations across years, but with marked differences in volumes within antibiotic groups across these years: a decrease in prescribing of narrow-spectrum penicillins (-29%), amoxicillin (-23%), tetracycline (-24%), doxycycline (-19%) and trimethoprim and derivatives (-45%) was accompanied by an increase in prescribing of co-amoxiclav (+85%), macrolides (+110%) and quinolones (+86%). CONCLUSIONS The international trend of a decline in the use of narrow-spectrum and older penicillins and prescribing more broad-spectrum and new chemotherapeutics was shown to exist in a low prescribing country, The Netherlands. Therefore, inappropriate antibiotic prescribing should remain prominent on the research agenda in intervention studies in order to improve the appropriate selection of antibiotic class and to reduce the prescription of antibiotics.
Outage Probability Analysis of Multi-Relay Delay-Limited Hybrid-ARQ Channels

We consider a wireless relay network with with hybrid-automatic retransmission request (HARQ) and Rayleigh fading channels. In this paper, we analyze the outage probability of the multi-relay delay-limited HARQ system with opportunistic relaying scheme in decode-and-forward mode. A simple and distributed relay selection strategy is proposed for multi-relay HARQ channels. Then, we analyze the performance of the system. We first derive the cumulative density function (CDF) and probability density function (PDF) of the selected relay channels. Then, the CDF and PDF are used to determine the outage probability in the l-th round of HARQ. The packet delay constraint is represented by L, the maximum number of HARQ rounds. Furthermore, closed-form upper-bounds on outage probability are derived, which are used to investigate the diversity order of the system. Based on the derived upper-bound expressions, it is shown that the proposed schemes achieve the full spatial diversity order of N + 1, where N is the number of potential relays. Our analytical results are confirmed by simulation results.
A comparison of student outcomes in a physical therapy neurologic rehabilitation course based on delivery mode: hybrid vs traditional.

BACKGROUND Physical therapy (PT) educators have been charged by the American Physical Therapy Association's Vision 2020 with the aim of developing critically reflective knowledge about teaching and learning using innovative teaching methods. Computer-assisted learning (CAL) affords the opportunity to supplement face-to-face teaching methods. The purpose of this study was to compare student performance and preferred instruction mode between a hybrid model using CAL modules and a traditional lecture-based model. METHODS The posttest-only control design used mixed methods to assess two successive student cohorts (2011 and 2012). Cohort 1 was instructed using only traditional teaching methods of lecture and laboratory experiences, while Cohort 2 was taught using both traditional teaching methods and the CAL modules created for 10 content areas. Students viewed each CAL module after the in-class lecture, prior to the corresponding laboratory. Student performance was assessed with weekly 10-question quizzes. One-minute papers and focus group discussions were administered to Cohort 2 to gauge satisfaction and perceptions of the CAL modules. RESULTS Results revealed that the mean quiz grades for Cohort 2 were higher than those for Cohort 1, 86.1 vs 80.4. When comparing final exam grades and final grades for the course between groups, a statistically significant difference exists with the final exam grade, p<0.01. DISCUSSION It appears that the CAL modules were useful to supplement this course content. Innovative, interactive, and varied teaching methodologies will serve to better engage students as lifelong learners.
Creating media with prescribed permeability using the asymptotic solution to EM wave scattering problem

Asymptotic solution to scattering problem of electromagnetic (EM) waves by many small impedance particles, embedded in a homogeneous medium, is applied for creating media with prescribed permeability. Physical properties of the particles are described by their boundary impedances. The limiting equation is obtained for the effective EM field in the resulting medium. The proposed theory allows one to create a medium with a desirable spatially inhomogeneous permeability. The main new physical result is the explicit analytic formula for the permeability μ(x) of the limiting medium. The computational results confirm a possibility to create the media with various distributions of μ(x).
Wild Bird Influenza Survey, Canada, 2005

Of 4,268 wild ducks sampled in Canada in 2005, real-time reverse transcriptase–PCR detected influenza A matrix protein (M1) gene sequence in 37% and H5 gene sequence in 5%. Mallards accounted for 61% of samples, 73% of M1-positive ducks, and 90% of H5-positive ducks. Ducks hatched in 2005 accounted for 80% of the sample.
Neurochemical regulation of auditory information processing studied with EEG/MEG: application to schizophrenia

4 TIIVISTELMÄ . 5 ACKNOWLEDGEMENTS . 6 LIST OF ORIGINAL PUBLICATIONS . 7 ABBREVIATIONS . 9
Modeling and analysis of dual-output piezoelectric transformer operating at thickness-shear vibration mode

In our previous study, the multioutput piezoelectric transformer operating at the thickness-shear vibration mode was proposed and experimentally investigated. By designing a new construction of support and lead wire connection, a power density of 52.7 W/cm3 and a total output power of 169.8 W were achieved at a temperature rise less than 20 degC. In this work, a theoretical model was developed for the dual-output piezoelectric transformer operating at the thickness-shear vibration mode. The equivalent circuit parameters of the piezoelectric transformer were derived. Based on this, the impedance characteristics, equivalent inductance, capacitance ratio, voltage gain, and efficiency of the piezoelectric transformer were calculated. The theoretical results were verified by experimental data. Furthermore, the effect of the transformer size on the voltage gain, efficiency, output power and power density, and the effect of the load of one output on the voltage gain of another output were analyzed. Some useful guidelines were achieved by these analyses
Consumer activity in social media: Managerial approaches to consumers' social media behavior

Today, consumers are involved in a variety of activities, ranging from consuming content to participating in discussions, sharing knowledge with other consumers, and contributing to other consumers' activities. With the enormous interest in social media sites, such as YouTube, MySpace, Facebook, and Wikipedia, consumers are assumed to be actively contributing to marketing content. However, despite the rich opportunities for contributing, recent academic research indicates that consumers are not necessarily as active online as has been believed. The aim of this paper is to conceptualize consumers' activities in social media by examining the motivations behind the activities. By offering a more detailed description of the differences in consumer use of social media, the study extends existing research on consumer activities related to user-created content. Based on consumer narratives of their social media activity, we identified 15 activities grouped under three themes. The conceptual framework is used to suggest managerial strategies related to different levels of consumer activity. Thus, it provides a tool for uncovering managerial challenges and for planning responses to consumer activities. Copyright © 2011 John Wiley & Sons, Ltd.
Hard Marriage with Heavy Burdens: Organized Labor as Takeover Deterrents

We examine how labor power affects a firm’s takeover exposure and merger gains. Using a regression discontinuity design that relies on “locally” exogenous variation in labor power generated by close-call union elections, we find that increased labor power significantly reduces a firm’s takeover exposure, reduces target offer premium and announcement returns, and prolongs deal completion duration. The results are stronger for more powerful and conflict-provoking unions. Bidders of unionized targets are experienced, are tough negotiators, and face fewer union threats by themselves. Our paper provides new insights into the real effects of shareholder-employee conflict regarding the market for corporate control. (JEL G34, G30, J51) Received: February 9, 2019; editorial decision January 15, 2020 by Editor Isil Erel. Authors have furnished an Internet Appendix, which is available on the Oxford University Press Web site next to the link to the final published paper online.
Ageing and Asset Prices

The paper investigates how ageing will affect asset prices. A small model is used to show that economic and demographic factors drive asset, and in particular house, prices. These factors are estimated in a panel regression framework encompassing BIS real house price data from 22 advanced economies between 1970 and 2009. The estimates show that demographic factors affect real house prices significantly. Combining the results with UN population projections suggests that ageing will lower real house prices substantially over the next forty years. The headwind is around 80 basis points per annum in the United States and much stronger in Europe and Japan. Based on the analysis, global asset prices are likely to face substantial headwinds from ageing.
Edinburgh Research Explorer Identification of a new inborn error in bile acid synthesis: Mutation of the oxysterol 7 alpha-hydroxylase gene causes severe neonatal liver disease

We describe a metabolic defect in bile acid synthesis involving a deficiency in 7 (cid:97) -hydroxylation due to a mutation in the gene for the microsomal oxysterol 7 (cid:97) -hydroxylase enzyme, active in the acidic pathway for bile acid synthesis. The defect, identified in a 10-wk-old boy presenting with severe cholestasis, cirrhosis, and liver synthetic failure, was established by fast atom bombardment ionization-mass spectrometry, which revealed elevated urinary bile acid excretion, a mass spectrum with intense ions at m/z 453 and m/z 510 corresponding to sulfate and glycosulfate conjugates of unsaturated monohydroxy-cholenoic acids, and an absence of primary bile acids. Gas chromatography-mass spectrometric analysis confirmed the major products of hepatic synthesis to be 3 (cid:98) -hydroxy-5-cholenoic and 3 (cid:98) -hydroxy-5-cholestenoic acids, which accounted for 96% of the total serum bile acids. Levels of 27-hydroxycholesterol were (cid:46) 4,500 times normal. The biochemical findings were consistent with a deficiency in 7 (cid:97) -hydroxylation, leading to the accumulation of hepatotoxic unsaturated monohydroxy bile acids. Hepatic microsomal oxysterol 7 (cid:97) -hydroxylase activity was undetectable in the patient. Gene analysis revealed a cytosine to thymidine transition mutation in exon 5 that converts an arginine codon at position 388 to a stop codon. The truncated protein was inactive when expressed in 293 cells. These findings indicate the quantitative importance of the acidic pathway in early life in humans and define a further inborn error in bile acid synthesis as a metabolic cause of severe cholestatic liver disease. ( J. Clin. Invest. 1998. 102: 1690—1703.)