Miracle-dz/UniFAR-FTUs huggingface dataset:
Organizational culture for lean programs

Purpose Recent studies suggest that the implementation of Lean will only be successful when aligned with organizational culture (OC). The purpose of this paper is to understand an Ideal Lean Culture (ILC) in the Brazilian context. Design/methodology/approach This diagnosis is based on the Competing Values Framework, and it is the result of a survey with 51 experts in charge of implementation of Lean programs in organizations operating in different industry segments in Brazil. Findings The results show that an ILC for Brazilian organizations seems to have the dominant profile of the hierarchy culture, thus characterizing a highly structured and formal place, with rules and procedures governing the behavior of people. Research limitations/implications Some limitations of this study include: although a survey has been applied, the research cannot be classified as a quantitative study; it brings the opinion of a limited number of Brazilian experts about lean programs; both the sample size could be increased and the nationality of respondents could be expanded for future research. Practical implications It is proposed that an organization (or an area of the organization) that wants to be successful in its lean journey must, first, measure its OC and then promote a cultural profile aligned with the results presented in this paper. By doing so, it is expected that this lean journey should have a higher probability of long-term success and sustainability of lean practices, concepts and philosophy. Originality/value In the last two decades much has been written about the importance of OC in the success of lean programs. However, very few studies has mapped and measured an ILC in a way that allows researchers, consultants and managers to evaluate if an OC is close to or distant from an ILC.
A Century of Hardy–Weinberg Equilibrium

Abstract Hardy–Weinberg equilibrium (HWE) is the state of the genotypic frequency of two alleles of one autosomal gene locus after one discrete generation of random mating in an indefinitely large population: if the alleles are A and a with frequencies p and q(=1-p), then the equilibrium gene frequencies are simply p and q and the equilibrium genotypic frequencies for AA, Aa and aa are p2, 2pq and q2. It was independently identified in 1908 by G. H. Hardy and W. Weinberg after earlier attempts by W. E. Castle and K. Pearson. Weinberg, well known for pioneering studies of twins, made many important contributions to genetics, especially human genetics. Existence of this equilibrium provides a reference point against which the effects of selection, linkage, mutation, inbreeding and chance can be detected and estimated. Its discovery marked the initiation of population genetics.
The Bankart repair versus the Putti-Platt procedure

Background and purpose This randomized study compared clinical results after surgery for posttraumatic shoulder instability with either an anatomical repair or an older, less anatomical but commonly used method. The less anatomical procedure has been considered quicker and less demanding, but it has been questioned regarding the clinical result. We therefore wanted to compare the clinical outcome of the two different procedures. Our hypothesis was that the anatomical repair would give less residual impairment postoperatively. Methods Patients with anterior posttraumatic shoulder instability were consecutively randomized on the day before surgery to either a Bankart repair using Mitek GI/GII anchors combined with capsular imbrication (B) (n = 33) or a Putti-Platt procedure (P) (n = 33). Follow-up was performed by examination at 2 years and using a self-evaluation score at 10 years. Results At the 2-year follow-up, we found no difference in muscle strength between patients treated with the two surgical methods and there were no statistically significant differences in the Rowe scores (mean 90 units for both groups). Compared to preoperatively, the decrease in external rotation 2 years after surgery was 10 degrees in the P group and 3 degrees in the B group (p = 0.03). 10 years after surgery, 62 of 66 patients replied to a questionnaire sent by mail. It included a self-evaluating quality of life score for shoulder instability (WOSI) for evaluation of their shoulder function. In the P group 15 patients and in the B group 19 patients reported they had experienced either a redislocation or a subluxation with a new feeling of shoulder instability. Mean WOSI score was similar in the P and B groups: 80% and 83%, respectively. The WOSI score was 87% for patients with stable shoulders (n = 28) and 77% for those with unstable shoulders (n =34) (p = 0.005). Interpretation With assessment of pain and general shoulder function, only a small difference was found between the two methods. The WOSI scores for stable shoulders indicated that some shoulders still had impaired function even though the shoulders had become stable.
Actor-critic versus direct policy search: a comparison based on sample complexity

Sample efficiency is a critical property when optimizing policy parameters for the controller of a robot. In this paper, we evaluate two state-of-the-art policy optimization algorithms. One is a recent deep reinforcement learning method based on an actor-critic algorithm, Deep Deterministic Policy Gradient (DDPG), that has been shown to perform well on various control benchmarks. The other one is a direct policy search method, Covariance Matrix Adaptation Evolution Strategy (CMA-ES), a black-box optimization method that is widely used for robot learning. The algorithms are evaluated on a continuous version of the mountain car benchmark problem, so as to compare their sample complexity. From a preliminary analysis, we expect DDPG to be more sample efficient than CMA-ES, which is confirmed by our experimental results.
Laplace Operator in Networks of Thin Fibers: Spectrum Near the Threshold

Our talk at Lisbon SAMP conference was based mainly on our recent results (published in Comm. Math. Phys.) on small diameter asymptotics for solutions of the Helmgoltz equation in networks of thin fibers. The present paper contains a detailed review of these results under some assumptions which make them much more transparent. It also contains several new theorems on the structure of the spectrum near the threshold. small diameter asymptotics of the resolvent, and solutions of the evolution equation.
Fake News or Truth? Using Satirical Cues to Detect Potentially Misleading News

Satire is an attractive subject in deception detection research: it is a type of deception that intentionally incorporates cues revealing its own deceptiveness. Whereas other types of fabrications aim to instill a false sense of truth in the reader, a successful satirical hoax must eventually be exposed as a jest. This paper provides a conceptual overview of satire and humor, elaborating and illustrating the unique features of satirical news, which mimics the format and style of journalistic reporting. Satirical news stories were carefully matched and examined in contrast with their legitimate news counterparts in 12 contemporary news topics in 4 domains (civics, science, business, and “soft” news). Building on previous work in satire detection, we proposed an SVMbased algorithm, enriched with 5 predictive features (Absurdity, Humor, Grammar, Negative Affect, and Punctuation) and tested their combinations on 360 news articles. Our best predicting feature combination (Absurdity, Grammar and Punctuation) detects satirical news with a 90% precision and 84% recall (F-score=87%). Our work in algorithmically identifying satirical news pieces can aid in minimizing the potential deceptive impact of satire.
The Diurnal Logic of the Expression of the Chloroplast Genome in Chlamydomonas reinhardtii

Chloroplasts are derived from cyanobacteria and have retained a bacterial-type genome and gene expression machinery. The chloroplast genome encodes many of the core components of the photosynthetic apparatus in the thylakoid membranes. To avoid photooxidative damage and production of harmful reactive oxygen species (ROS) by incompletely assembled thylakoid protein complexes, chloroplast gene expression must be tightly regulated and co-ordinated with gene expression in the nucleus. Little is known about the control of chloroplast gene expression at the genome-wide level in response to internal rhythms and external cues. To obtain a comprehensive picture of organelle transcript levels in the unicellular model alga Chlamydomonas reinhardtii in diurnal conditions, a qRT-PCR platform was developed and used to quantify 68 chloroplast, 21 mitochondrial as well as 71 nuclear transcripts in cells grown in highly controlled 12 h light/12 h dark cycles. Interestingly, in anticipation of dusk, chloroplast transcripts from genes involved in transcription reached peak levels first, followed by transcripts from genes involved in translation, and finally photosynthesis gene transcripts. This pattern matches perfectly the theoretical demands of a cell “waking up” from the night. A similar trend was observed in the nuclear transcripts. These results suggest a striking internal logic in the expression of the chloroplast genome and a previously unappreciated complexity in the regulation of chloroplast genes.
The impact of starbursts and post-starbursts on the photometric evolution of high redshift galaxies

We present evolutionary synthesis models for galaxies of spectral types Sa through Sd with starbursts of various strengths triggered at various redshifts and study their photometric evolution before, during, and after their bursts in a cosmological context. We find that bursts at high redshift, even very strong ones, only cause a small blueing of their intrinsically blue young parent galaxies. At lower redshift, in contrast, even small bursts cause a significant blueing of their intrinsically redder galaxies. While the burst phase is generally short, typically a few hundred Myr in normal-mass galaxies, the postburst stage with its red colors and, in particular the very red ones for early bursts at high redshift, lasts much longer, on the order of several Gyr. We find that, even without any dust, which in the postburst stage is not expected to play an important role anyway, models easily reach the colors of EROs in the redshift range z ∼ 2 through z ∼ 0.5 after starbursts at redshifts between 2 and 4. We therefore propose a third alternative for the ERO galaxies beyond the two established ones of passive galaxies vs. dusty starbursts: the dust-free post-(strong-)starbursts. A very first comparison of our models to HDF data with photometric redshifts shows that almost all of the outliers that could not be described with our chemically consistent models for undisturbed normal galaxy types E through Sd can now be explained very well. Galaxies in the redshift range from z ∼ 2.5 to z ∼ 0.5 that are redder, and in some cases much redder, than our reddest undisturbed model for a high-metallicity classical elliptical are well described by post-starburst models after starbursts at redshifts between 2 and 4. Galaxies bluer than our bluest low metallicity Sd model, most of which have redshifts lower than 1, are well explained by ongoing starbursts.
Measurement of aldosterone in human plasma by semiautomated HPLC-tandem mass spectrometry.

BACKGROUND Reliable measurement of aldosterone with less interlaboratory variation than RIA would help standardize testing for primary aldosteronism. We set out to validate a high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method for aldosterone in human plasma. METHODS We prepared samples (EDTA plasma, lithium heparin plasma, and serum from separator and plain clot tubes) and measured aldosterone using online HPLC-MS/MS with d(7)-aldosterone as internal standard. We also analyzed EDTA plasma samples by immunoassay. We established a reference range for HPLC-MS/MS aldosterone by analyzing blood collected midmorning from 97 normotensive seated subjects. RESULTS The linear range was 69.4-5548.0 pmol/L (2.5-200 ng/dL) (r(2) > 0.994, n = 14). Inter- and intraday analytical recovery and imprecision for quality control samples of 166.4, 1109.6, and 4161.0 pmol/L (6.0, 40.0, and 150.0 ng/dL) were 92.2%-102.0% and <6.3%, respectively (n = 5). The lower limit of quantification was 69.4 pmol/L (2.5 ng/dL), with inter- and intraday analytical recovery and imprecision of 91.4%-94.5% and <9.5% (n = 5). No interferences were observed in plasma from Addison's disease patients (n = 5). Comparison of collection tubes, using EDTA as the reference, revealed similar aldosterone results. Comparison of HPLC-MS/MS with immunoassay gave an acceptable mean bias (0.83%) but wide range (-44.8% to 39.7%) of differences. HPLC-MS/MS aldosterone concentrations in normotensive subjects ranged from <69.4 to 635.2 pmol/L (<2.5 to 22.9 ng/dL). CONCLUSIONS This first reported aldosterone method using online HPLC-MS/MS is precise across the clinically relevant range, not influenced by collection tube type, and offers semiautomated sample preparation and high throughput.
Efficacy and Safety of Up to 8 Years of Long-term Growth Hormone Treatment in Short Children Born Small for Gestational Age in Japan: Analysis of the Subpopulation According to the Japanese Guideline

The efficacy and safety of 8 yr of GH treatment was assessed in 44 Japanese children with small for gestational age (SGA) short stature who met the criteria for GH treatment initiation (height SD score (SDS) <–2.5 SD) of the Japanese guidelines. Height SDS in subjects improved throughout the study period, and average height SDS improved from –3.5 to –1.6 and from –3.4 to –1.9 in the 0.033/0.067 mg and 0.067/0.067 mg groups, respectively, after 8 yr of GH treatment. Delta height SD was approximately +2 after 4 yr of treatment, and ∆ IGF-1 showed a significant positive correlation with ∆ height SD after both 1 and 2 yr (r = 0.415 and 0.488, respectively) of treatment. There was no correlation between the age at the start of treatment and age at onset of puberty, and the median age at the onset of puberty in the subjects was almost the same as that in healthy children. In conclusion, clinically significant improvements in the height SDS was confirmed in short children born SGA after 8 yr of GH treatment without any safety problems.
Critical Appraisal Guidelines for Single Case Study Research

The use of critical appraisal guidelines to assess the validity of research findings has become an established technique in those disciplines, such as healthcare and medicine, that encourage the use of evidence-based practice. Critical appraisal guidelines provide a rigorous set of criteria, often in the form of a checklist, against which a piece of research can be assessed. Although well established criteria exist for many forms of quantitative research, such as clinical trials and cohort studies, qualitative research is less well served. Through a synthesis of existing best practices in interpretative research this paper provides comprehensive guidelines for the conduct of single case study research and extrapolates from them a set of critical appraisal guidelines to assist in the evaluation of such work.
Automatic Detection Of New Words In A Large Vocabulary Continuous Speech Recognition System

A preliminary investigation of techniques that automatically detect when a speaker has used a word that is not in the vocabulary of a continuous-speech recognition system is described. A technique that uses a general model for the acoustics of any word to recognize the existence of new words is developed. Using this general word model, the correct detection of new words versus the false alarm rate is measured. Experiments were run using the DARPA 1000-word Resource Management Database indicate a detection rate for new words of 74% with a false alarm rate of 3.4%. <<ETX>>
Effects of combined exercise on cardiovascular risk factors and serum BDNF level in mid-aged women

[Purpose] The purposes of this study is first to examine a positive effect of long term combined exercise including aerobic and resistance exercise on increasing level of serum BDNF, and investigate how aerobic exercise is related to improving BDNF circulation and resistance exercise improves fat oxidation in mid-aged women. [Methods] Initially, 30 mid-aged women, according to their exercise preference, was randomly assigned as a non-exercise group (n=7, control group; CG) and exercise group (n=23). Then, 23 exercise participants were divided by aerobic exercise group (n=15, AEG) and combination of aerobic and resistance exercise group (n=8, CEG). Prior to the experiment, all participants’maximal oxygen uptake (VO2max), body composition, and blood factors were measured. Changes (Δ delta value) in body composition, fitness level, and serum BDNF level of the different groups were tested through one way ANOVA. [Results] For AEG and CG after 24 weeks, VO2max and high-density lipoprotein cholesterol (HDL-C) were significantly increased. During this period, CEG had significant increase in muscular strength and decrease in triglyceride (TG) total cholesterol (TC)/HDL-C (p=0.013). Continuously, serum BDNF concentration of both AEG and CEG was significantly increased (F=6.328, p=0.001) compared to CG. There, however, was no significant between-group difference. [Conclusion] Although there was no difference in serum BDNF level between AEG and CEG, we confirmed that CEG may have a possibility of positive changes in increase of serum BDNF level in mid-aged women.
Review Article Transforming Growth Factor-beta and Matrix Metalloproteinases: Functional Interactions in Tumor Stroma-infiltrating Myeloid Cells

Transforming growth factor-beta (TGF-í µí»½) is a pleiotropic factor with several different roles in health and disease. In tumorigenesis, it may act as a protumorigenic factor and have a profound impact on the regulation of the immune system response. Matrix metalloproteinases (MMPs) are a family that comprises more than 25 members, which have recently been proposed as important regulators acting in tumor stroma by regulating the response of noncellular and cellular microenvironment. Tumor stroma consists of several types of resident cells and infiltrating cells derived from bone marrow, which together play crucial roles in the promotion of tumor growth and metastasis. In cancer cells, TGF-í µí»½ regulates MMPs expression, while MMPs, produced by either cancer cells or residents' stroma cells, activate latent TGF-í µí»½ in the extracellular matrix, together facilitating the enhancement of tumor progression. In this review we will focus on the compartment of myeloid stroma cells, such as tumor-associated macrophages, neutrophils, and dendritic and mast cells, which are potently regulated by TGF-í µí»½ and produce large amounts of MMPs. Their interplay and mutual implications in the generation of pro-tumorigenic cancer microenvironment will be analyzed.
Ontology of the Mirror World

The “mirror world” (Spiegelwelt or Gegenwelt) was introduced by Jakob von Uexkull (1920; Bernhard Hassenstein 2001). It marks a metabletic (Bertha Mook 2009; Jan Hendrik van den Berg 1956) turn in the life sciences of the first quarter of the 20thc. , contemporary with major paradigm shifts in physics (e.g., Albert Einstein 1905; Niels Bohr 1905-1911; Erwin Schrodinger 1926; .), philosophy (e.g., Edmund Husserl 1913; Alexius Meinong 1899; Brett Buchanan 2008; .), psychology (e.g., Carl Stumpf 1918; Max Wertheimer 1922-3; Wolfgang Kohler 1929; .), and the arts (for instance, Rainer Maria Rilke (1902) in poetry and Franz Marc (1880–1916) in painting). Augmented with somewhat later ideas concerning the genesis of awareness (Schrodinger 1958; Jason Walter Brown 1991; .) and methods of probing (Whitman Richards 1982; Jan Koenderink 2011a; .) one obtains a rough, but coherent account of the psychogenesis of visual awareness. I start by introducing the concept of mirror world (Spiegelwelt) and so forth, then discuss their role in an ontology of the objects of visual awareness, the Gestalts.
Mycoketide: A CD1c-Presented Antigen with Important Implications in Mycobacterial Infection

Mycobacterium tuberculosis and related mycobacteria species are unique in that the acid-fast bacilli possess a highly lipid-rich cell wall that not simply confers resistance to treatment with acid alcohol, but also controls their survival and virulence. It has recently been established that a fraction of the cell wall lipid components of mycobacteria can function as antigens targeted by the acquired immunity of the host. Human group 1 CD1 molecules (CD1a, CD1b, and CD1c) bind a pool of lipid antigens expressed by mycobacteria and present them to specific T cells, thereby mediating an effective pathway for host defense against tuberculosis. The contrasting and mutually complementary functions of CD1a and CD1b molecules in terms of the repertoire of antigens they bind have been well appreciated, but it remains to be established how CD1c may play a unique role. Nevertheless, recent advances in our understanding of the CD1c structure as well as the biosynthetic pathway of a CD1c-presented antigen, mannose-1, β-phosphomycoketide, expressed by pathogenic mycobacteria now unravel a new aspect of the group 1 CD1 biology that has not been appreciated in previous studies of CD1a and CD1b molecules.
Predictors of IAPT psychological well-being practitioners’ intention to use CBT self-help materials routinely in their clinical practice

Abstract Despite efficacy and effectiveness evidence, and recommendations from the National Institute for Health and Care Excellence (NICE), use of CBT self-help materials remains inconsistent in UK mental health services. Since 2006, the Improving Access to Psychological Therapies (IAPT) programme has provided standardized training and mandates routine use of CBT self-help materials by their trainee psychological well-being practitioners (PWPs). This study tested whether the main constructs of the theory of planned behaviour (TPB; attitudes, subjective norms, and perceived behavioural control), past use, prior training and demographic characteristics, would predict PWPs’ intention to use self-help materials routinely in their clinical practice. Stage 1 utilized a standardized procedure to create measures for the constructs of TPB, before the design and testing of a web-based, cross-sectional questionnaire. In stage 2, the questionnaire was administered to a convenience sample of trainee PWPs (n = 94). Data was analysed using multiple linear regression, mediation analyses, and content analysis. TPB constructs predicted intention to use self-help materials, with only direct attitude contributing significantly to 70% of the variance in intention. Past use of materials predicted intention, via direct and indirect mediation. Qualitative data from 43 trainees highlighted clients’ experience of self-help materials as positive, albeit with some practical constraints. The results suggest that the main constructs of TPB have some utility in predicting trainee PWPs’ intention to use self-help materials routinely. Future prospective, longitudinal research could investigate actual use of self-help materials to elucidate cognitive factors involved in trainees’ clinical decision-making post-qualification.