Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of Servo Loop Modulation in Atomic Beam Frequency Standards Employing a Ramsey Cavity

Some kind of modulation needs to be imposed on the mi- crowave signal to acquire lock in all passive atomic frequency stan- dards. In this way a frequency-discriminating dc signal is obtained by synchronous detection, which allows control of a slave oscillator. Fre- quency stability and frequency biases of the latter under closed-loop operation depend on the type and characteristics of the used modula- tion. The case of atomic beam standards using a Ramsey cavity is stud- ied, and different modulation schemes are considered under the aspects of efficiency (obtainable stability) and insensitivity to systematic effects. Theoretical results for the dependence of these on modulation type and parameters and on microwave power are reported and discussed. schemes and their sensitivity to some systematic effects are given as a function of modulation type and parame- ters, and are calculated numerically for an existing atomic beam tube. In particular, the effects of sine-wave modu- lation and slow square-wave frequency modulation on short-term stability and on various biases are discussed. A perfect realization of these ideal schemes will be as- sumed, and system imperfections like second harmonic distortion will be overlooked in the scope of this paper. 11. SYSTEM ANALYSIS Whatever the particular coherent detection system may be, signal processing of the modulated output Pod from the atomic resonator can be ideally divided in two steps: a filter section with a time-dependent output IF synchron- ous with the modulation, and a __ phase-sensitive detector with a time-independent output Pd.
Workshop overview: approaches to the assessment of the allergenic potential of food from genetically modified crops.

There is a need to assess the safety of foods deriving from genetically modified (GM) crops, including the allergenic potential of novel gene products. Presently, there is no single in vitro or in vivo model that has been validated for the identification or characterization of potential food allergens. Instead, the evaluation focuses on risk factors such as source of the gene (i.e., allergenic vs. nonallergenic sources), physicochemical and genetic comparisons to known allergens, and exposure assessments. The purpose of this workshop was to gather together researchers working on various strategies for assessing protein allergenicity: (1) to describe the current state of knowledge and progress that has been made in the development and evaluation of appropriate testing strategies and (2) to identify critical issues that must now be addressed. This overview begins with a consideration of the current issues involved in assessing the allergenicity of GM foods. The second section presents information on in vitro models of digestibility, bioinformatics, and risk assessment in the context of clinical prevention and management of food allergy. Data on rodent models are presented in the next two sections. Finally, nonrodent models for assessing protein allergenicity are discussed. Collectively, these studies indicate that significant progress has been made in developing testing strategies. However, further efforts are needed to evaluate and validate the sensitivity, specificity, and reproducibility of many of these assays for determining the allergenicity potential of GM foods.
The relative importance of direct and indirect effects of hunting mortality on the population dynamics of brown bears

There is increasing evidence of indirect effects of hunting on populations. In species with sexually selected infanticide (SSI), hunting may decrease juvenile survival by increasing male turnover. We aimed to evaluate the relative importance of direct and indirect effects of hunting via SSI on the population dynamics of the Scandinavian brown bear (Ursus arctos). We performed prospective and retrospective demographic perturbation analyses for periods with low and high hunting pressures. All demographic rates, except yearling survival, were lower under high hunting pressure, which led to a decline in population growth under high hunting pressure (λ = 0.975; 95% CI = 0.914–1.011). Hunting had negative indirect effects on the population through an increase in SSI, which lowered cub survival and possibly also fecundity rates. Our study suggests that SSI could explain 13.6% of the variation in population growth. Hunting also affected the relative importance of survival and fecundity of adult females for population growth, with fecundity being more important under low hunting pressure and survival more important under high hunting pressure. Our study sheds light on the importance of direct and indirect effects of hunting on population dynamics, and supports the contention that hunting can have indirect negative effects on populations through SSI.
Machine learning on Web documents

The Web is a tremendous source of information: so tremendous that it becomes difficult for human beings to select meaningful information without support. We discuss tools that help people deal with web information, by, for example, blocking advertisements, recommending interesting news, and automatically sorting and compiling documents. We adapt and create machine learning algorithms for use with the Web's distinctive structures: large-scale, noisy, varied data with potentially rich, human-oriented features. Two standard classification algorithms, the slow but powerful support vector machine and the fast but inaccurate Naive Bayes, are modified to make them more effective for the Web. The support vector machine, which cannot currently handle the large amount of Web data potentially available, is sped up by “bundling” the classifier inputs to reduce the input size. The Naive Bayes classifier is improved through a series of three techniques aimed at fixing some of the severe, inaccurate assumptions Naive Bayes makes. Classification can also be improved by exploiting the Web's rich, human-oriented structure, including the visual layout of links on a page and the URL of document. These “tree-shaped features” are placed in a Bayesian mutation model and learning is accomplished with a fast, online learning algorithm for the model. These new methods are applied to a personalized news recommendation tool, “the Daily You. ” The results of a 176 person user-study of news preferences indicate that the new Web-centric techniques out-perform classifiers that use traditional text algorithms and features. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617-253-5668; Fax 617-253-1690.)
Vascular flow density in pathological myopia: an optical coherence tomography angiography study

Objectives To investigate vascular flow density in pathological myopia with optical coherence tomography (OCT) angiography. Design A prospective comparative study was conducted from December 2015 to March 2016. Setting Participants were recruited in Beijing Tongren Hospital. Participants A total of 131 eyes were enrolled, which were divided into three groups: 45 eyes with emmetropia (EM; mean spherical equivalent (MSE) 0.50D to −0.50D), 41 eyes with high myopia (HM; MSE ≤−6.00D, without pathological changes), and 45 eyes with pathological myopia (PM; MSE ≤−6.00D and axial length (AL) ≥26.5 mm, and with pathological changes). Main outcome measures Macular, choriocapillaris and radial peripapillary capillary (RPC) flow densities were measured and compared between groups, and their relationships with AL and best corrected visual acuity (BCVA) were analysed. Results Significant differences were found in macular, choriocapillaris and RPC flow densities among the three groups (p<0.05). Multiple comparisons revealed that, compared with the EM and HM groups, macular and RPC flow densities of the PM group were significantly decreased (p<0.05), but no significant difference in choriocapillaris flow density was found between the PM and HM groups (p=0.731). Compared with the EM group, retinal flow density in the macular and arcuate fibre region was not decreased in the HM group. In addition, there was a negative correlation between AL and superficial macular flow density (β=−0.542, p<0.001), deep macular flow density (β=−0.282, p=0.002) and RPC flow density (β=−0.522, p<0.001); and a positive correlation between BCVA and superficial macular flow density (β=0.194, p=0.021), deep macular flow density (β=0.373, p<0.001), and choriocapillaris flow density (β=0.291, p=0.001). Conclusions Macular and RPC flow densities decreased in pathological myopia compared with high myopia and emmetropia. No significant decrease of retinal flow density in the macular and arcuate fibre region was found in high myopic eyes compared with emmetropic eyes. Moreover, macular and RPC flow densities were negatively related to AL, and macular flow density was positively related to BCVA.
Early Versus Delayed Treatment of Severe Ankle Fractures: A Comparison of Results

Summary: A retrospective review of 202 closed Weber B bimalleolar or bimalleolar equivalent ankle fractures treated using open reduction and internal fixation (ORIF) from January 1, 1991, through January 1, 1994 was completed at our institution. A total of 105 ankles (52%) were treated using ORIF within 5 days of injury (early group), with a mean 1.5 days from injury to surgery, A total of 97 ankles (48%) were treated after 5 days (delayed group), with a mean of 13.6 days from injury to surgery. Operative time, length of hospital stay, postoperative range of motion, adequacy of reduction, wound and other complications, and other sequelae were compared between the two groups. No significant difference in range of motion at latest follow-up or in operative time was evident between the groups. Minor wound complications were present in 4.8% of the early group compared with 6.2% in the delayed group. No deep infections or osteomyelitis were present in either group. Anatomic reductions were present in 89% and poor reductions (>2 mm displacement) in 1% of those ankles treated within 5 days versus 83% anatomic reductions and 3% poor reductions in those treated after 5 days. The differences in wound complications and anatomic reductions between groups was not statistically significant. There was a significantly longer median hospital stay in the early (3 days) versus delayed groups (2 days). We conclude that the results and complications of early versus delayed treatment is not significantly different, except for a shorter median hospital stay in the delayed group. Delayed ORIF is an acceptable alternative when soft-tissue swelling, fracture blisters, or abrasions are present that offer an undesirable environment for surgical incisions. Using contemporary, atraumatic techniques, delayed surgery can provide anatomic reduction with minimal complications in severe ankle fractures.
Dental application of novel finite element analysis software for three-dimensional finite element modeling of a dentulous mandible from its computed tomography images

This study focused on the application of novel finite-element analysis software for constructing a finite-element model from the computed tomography data of a human dentulous mandible. The finite-element model is necessary for evaluating the mechanical response of the alveolar part of the mandible, resulting from occlusal force applied to the teeth during biting. Commercially available patient-specific general computed tomography–based finite-element analysis software was solely applied to the finite-element analysis for the extraction of computed tomography data. The mandibular bone with teeth was extracted from the original images. Both the enamel and the dentin were extracted after image processing, and the periodontal ligament was created from the segmented dentin. The constructed finite-element model was reasonably accurate using a total of 234,644 nodes and 1,268,784 tetrahedral and 40,665 shell elements. The elastic moduli of the heterogeneous mandibular bone were determined from the bone density data of the computed tomography images. The results suggested that the software applied in this study is both useful and powerful for creating a more accurate three-dimensional finite-element model of a dentulous mandible from the computed tomography data without the need for any other software.
Better test cases for better automated program repair

Automated generate-and-validate program repair techniques (G&V techniques) suffer from generating many overfitted patches due to in-capabilities of test cases. Such overfitted patches are incor- rect patches, which only make all given test cases pass, but fail to fix the bugs. In this work, we propose an overfitted patch detec- tion framework named Opad (Overfitted PAtch Detection). Opad helps improve G&V techniques by enhancing existing test cases to filter out overfitted patches. To enhance test cases, Opad uses fuzz testing to generate new test cases, and employs two test or- acles (crash and memory-safety) to enhance validity checking of automatically-generated patches. Opad also uses a novel metric (named O-measure) for deciding whether automatically-generated patches overfit. Evaluated on 45 bugs from 7 large systems (the same benchmark used by GenProg and SPR), Opad filters out 75.2% (321/427) over- fitted patches generated by GenProg/AE, Kali, and SPR. In addition, Opad guides SPR to generate correct patches for one more bug (the original SPR generates correct patches for 11 bugs). Our analysis also shows that up to 40% of such automatically-generated test cases may further improve G&V techniques if empowered with better test oracles (in addition to crash and memory-safety oracles employed by Opad).
ON THE SECOND ORDER BEHAVIOUR OF THE BOOTSTRAP OF L1 REGRESSION ESTIMATORS

We consider the second-order asymptotic properties of the bootstrap of L 1 regression esti-mators by looking at the diierence between the L 1 estimator and its rst-order approximation, where the latter is the minimizer of a quadratic approximation to the L 1 objective function. It is shown that the bootstrap distribution of the normed diierence does not converge (either in probability or with probability 1) to the \correct" limiting distribution but rather converges in distribution to a random distribution. A characterization of this random distribution is given.
Semantic Textual Similarity for MT evaluation

This paper describes the system used for our participation in the WMT12 Machine Translation evaluation shared task. We also present a new approach to Machine Translation evaluation based on the recently defined task Semantic Textual Similarity. This problem is addressed using a textual entailment engine entirely based on WordNet semantic features. We described results for the Spanish-English, Czech-English and German-English language pairs according to our submission on the Eight Workshop on Statistical Machine Translation. Our first experiments reports a competitive score to system level.
Evolutionary inference of biochemical reaction networks accelerated on graphics processing units

The reverse engineering (RE) of biochemical reaction networks is a fundamental and very complex task in Systems Biology. My PhD thesis is focused on the definition of an automatic RE methodology based on the fusion of Genetic Programming and Particle Swarm Optimization. The methodology I propose relies on the execution of a massive number of simulations, whose computational costs are relevant. To the aim of reducing the overall running time, I am implementing the methodology on a parallel architecture, namely, Nvidia's CUDA.
Arterial Smooth Muscle Cell Heterogeneity: Implications for Atherosclerosis and Restenosis Development

Abstract—During atheromatous plaque formation or restenosis after angioplasty, smooth muscle cells (SMCs) migrate from the media toward the intima, where they proliferate and undergo phenotypic changes. The mechanisms that regulate these phenomena and, in particular, the phenotypic modulation of intimal SMCs have been the subject of numerous studies and much debate during recent years. One view is that any SMCs present in the media could undergo phenotypic modulation. Alternatively, the seminal observation of Benditt and Benditt that human atheromatous plaques have the features of a monoclonal or an oligoclonal lesion has led to the hypothesis that a predisposed, medial SMC subpopulation could play a crucial role in the production of intimal thickening. The presence of a distinct SMC population in the arterial wall implies that under normal conditions, SMCs are phenotypically heterogeneous. The concept of SMC heterogeneity is gaining wider acceptance, as shown by the increasing number of publications on this subject. In this review, we discuss the in vitro studies that demonstrate the presence of distinct SMC subpopulations in arteries of various species, including humans. Their specific features and their regulation will be highlighted. Finally, the relevance of an atheroma-prone phenotype to intimal thickening formation will be discussed.
The Effect of Cingulate Cortex Lesions on Task Switching and Working Memory

Anatomic interconnections between the prefrontal and anterior cingulate cortices suggest that these areas may have similar functions. Here we report the effect of anterior cingulate removal on task switching, error monitoring, and working memory. Neuroimaging studies have implicated the cingulate cortex in all these processes. Six macaques were taught task switching (TS) and delayed alternation (DA) paradigms. TS required switching between two conditional response tasks with mutually incompatible response selection rules. DA required alternation between two identically covered food-well positions. In the first set of experiments, anterior cingulate lesions did not consistently impair TS or DA performance. One animal performed worst on both TS and DA and in this animal the cingulate sulcus lesion was most complete. In the second set of experiments, we confirmed that larger anterior cingulate lesions, which included the sulcus, consistently impaired TS but only led to a mild and equivocal impairment of DA. The TS error pattern, however, did not suggest an impairment of TS per se. The consequence of a cingulate lesion is, therefore, distinct to that of a prefrontal lesion. TS error distribution analyses provided some support for a cingulate role in monitoring responses for errors and subsequent correction but the pattern of reaction time change in TS was also indicative of a failure to sustain attention to the task and the responses being made.
Characterizing the traffic distribution in linear wireless sensor networks

In a multi-hop wireless sensor network (WSN), the traffic load is not evenly distributed over the nodes. For example, the sensors which are one hop away from the sink relay the whole network traffic. This imbalanced traffic distribution can degrade the network lifetime and functionality. Here, an analysis is proposed to characterize the traffic load distribution over a randomly deployed linear WSN. The effect of the number of nodes and their distribution over the network is taken into account and the results are verified through computer simulation.
Offloading in Heterogeneous Networks: Modeling, Analysis, and Design Insights

Pushing data traffic from cellular to WiFi is an example of inter radio access technology (RAT) offloading. While this clearly alleviates congestion on the over-loaded cellular network, the ultimate potential of such offloading and its effect on overall system performance is not well understood. To address this, we develop a general and tractable model that consists of M different RATs, each deploying up to K different tiers of access points (APs), where each tier differs in transmit power, path loss exponent, deployment density and bandwidth. Each class of APs is modeled as an independent Poisson point process (PPP), with mobile user locations modeled as another independent PPP, all channels further consisting of i.i. d. Rayleigh fading. The distribution of rate over the entire network is then derived for a weighted association strategy, where such weights can be tuned to optimize a particular objective. We show that the optimum fraction of traffic offloaded to maximize SINR coverage is not in general the same as the one that maximizes rate coverage, defined as the fraction of users achieving a given rate.
Web service selection with global constraints using modified gray wolf optimizer

Web service composition is the process of assembling new services from the existing individual services. Due to the plenty of web services exhibiting similar functionality but different in terms of Quality-of-Service (QoS) requirements, the selection of an optimal service is a very crucial task. Consequently, the composition of web services with optimal QoS has become an important as well as the challenging problem. In this paper, a population-based optimization technique namely modified gray wolf optimizer (MGWO) is used for selecting the optimal set of services. We test the MGWO over the test case from the public repository of 2500 web services with nine different QoS attribute. The experimental results divulge that: (a) the MGWO is an effective and powerful approach to extract optimal services in diverse situations, and (b) the MGWO performs better than two other state-of-the-art algorithms: GA and GWO, finding the services with optimized QoS.
Endogenous Hepadnaviruses in the Genome of the Budgerigar (Melopsittacus undulatus) and the Evolution of Avian Hepadnaviruses

ABSTRACT Endogenous hepadnaviruses (hepatitis B viruses [HBVs]) were recently discovered in the genomes of passerine birds. We mined six additional avian genomes and discovered multiple copies of endogenous HBVs in the budgerigar (order Psittaciformes), designated eBHBV. A phylogenetic analysis reveals that the endogenous hepadnaviruses are more diverse than their exogenous counterparts and that the endogenous and exogenous hepadnaviruses form distinct lineages even when sampled from the same avian order, indicative of multiple genomic integration events.