Miracle-dz/UniFAR-FTUs huggingface dataset:
Everolimus Versus Azathioprine in Maintenance Lung Transplant Recipients: An International, Randomized, Double‐Blind Clinical Trial

Everolimus is a proliferation signal inhibitor with immunosuppressive activity that may reduce the rate of progression of chronic rejection, bronchiolitis obliterans syndrome (BOS), after lung transplantation. In a randomized, double‐blind clinical trial, 213 BOS‐free maintenance patients received everolimus (3 mg/day) or azathioprine (AZA, 1–3 mg/kg/day) in combination with cyclosporine and corticosteroids. The prospectively defined primary endpoint was the incidence of efficacy failure (decline in FEV1 >15%[ΔFEV1 >15%], graft loss, death or loss to follow‐up) at 12 months. Incidence of efficacy failure at 12 months was significantly lower in the everolimus group than AZA (21.8% vs. 33.9%; p = 0.046); at 24 months, rates of efficacy failure became similar between the groups. At 12 months, the everolimus group had significantly reduced incidences of ΔFEV1 >15%, ΔFEV1 >15% with BOS, and acute rejection. At 24 months, only incidence of acute rejection remained significantly less in the everolimus group. Treatment discontinuations (particularly due to adverse events), serious adverse events and high serum creatinine values were more common with everolimus. For the first time, a drug has demonstrated significant slowing of loss in lung function, suggesting that patients kept on prolonged maintenance treatment with everolimus may benefit from replacing AZA with everolimus 3 months after lung transplantation.
Resolvin D1 Protects Podocytes in Adriamycin-Induced Nephropathy through Modulation of 14-3-3β Acetylation

Resolvin D1 (RvD1) is a lipid-derived mediator generated during the resolution inflammation. While the immunoresolvent effects of Resolvins have been extensively studied in leukocytes, actions of Resolvins on intrinsic kidney cells have received little attention. The podocyte plays a central role in glomerular function, and podocyte damage can lead to proteinuria and glomerulosclerosis. This study examined whether RvD1 has renoprotective effects upon podocytes. We investigated a mouse model of adriamycin (ADR) nephropathy featuring rapid induction of podocyte damage and proteinuria followed by glomerulosclerosis. We identified a progressive loss of synaptopodin expression over a 28 day time-course of ADR nephropathy which was associated with increased acetylation of 14-3-3β and reduced synaptopodin phosphorylation. Groups of mice were given once daily RvD1 treatment (4 ng/g body weight/day) starting either 30 min (early treatment) or 14 days (late treatment) after ADR injection and continued until mice were killed on day 28. Early, but not late, RvD1 treatment attenuated ADR-induced proteinuria, glomerulosclerosis and tubulointerstitial fibrosis, modified macrophages from an M1 to M2 phenotype. Early RvD1 treatment prevented the down-regulation of synaptopodin expression and changes in 14-3-3β acetylation and synaptopodin phosphorylation. In a podocyte cell line, RvD1 was shown to prevent rapid TNF-α-induced down-regulation of synaptopodin expression. In transfection studies, TNF-α-induced a decrease in synaptopodin phosphorylation and an increase in acetylation of 14-3-3β, resulting in disassociation between 14-3-3β and synaptopodin. RvD1 prevented TNF-α induced post-translational modification of synaptopodin and 14-3-3β proteins, and maintained the synaptopodin/14-3-3β interaction. Furthermore, replacement of lysine K51, or K117+K122 in 14-3-3β with glutamine, to mimic lysine acetylation, significantly reduced the interaction between 14-3-3β and synaptopodin. In conclusion, our studies provide the first evidence that RvD1 can protect against podocyte damage by preventing down-regulation of synaptopodin through inhibition of 14-3-3β/synaptopodin dissociation. RvD1 treatment may have potential application in the treatment of chronic kidney disease.
Consonance and topological completeness in analytic spaces

We give a set-valued criterion for a topological space X to be consonant, i.e. the upper Kuratowski topology on the family of all closed subsets of X coincides with the co-compact topology. This characterization of consonance is then used to show that the statement "every analytic metrizable consonant space is complete" is independent of the usual axioms of set theory. This answers a question by Nogura and Shakhmatov. It is also proved that continuous open surjections defined on a consonant space are compact covering. A topological space X is said to be consonant if the co-compact topology on the set of all closed subsets of X coincides with the upper Kuratowski topology. The class of consonant spaces was introduced by Dolecki, Greco and Lechicki in [2], [3] and was recently studied rather intensively. It was noticed by Nogura and Shakhmatov in [8] that two other classical topologies (automatically) coincide on the set of closed subsets of a consonant space, namely, the Fell topology and the Kuratowski topology. In [3], among other things, it is proved that every Cechcomplete space is consonant. It is also known that metrizable consonant spaces are hereditarily Baire [1] (i.e. every closed subspace of a metrizable consonant metric space is a Baire space). These results prompted Nogura and Shakhmatov in [8, Problem 11.4] to ask whether consonant metrizable spaces are (Cech-)complete. This remained one of the central open problems in the theory of consonance. For coanalytic metrizable spaces, this problem is entirely solved: A co-analytic metrizable space X is consonant if and only if X is Polish (see [1]). In this note we show that the statement "every analytic metrizable consonant space is complete" is independent of the usual axioms of set theory (Theorem 6). It is also proved that continuous open surjections defined on a consonant space are compact covering (Corollary 8), which gives a generalization of the classical theorem of Pasynkov stated for Cechcomplete spaces. Corollary 8, along with a construction of Michael [6], allows us to give a new and topological proof of the nonconsonance of the usual space of rationals. This note is based on a characterization of consonance in terms of a special property of lower semicontinuous set-valued maps (Theorem 2). Concerning topological completeness, an important and recent result of this kind, achieved by van Mill, Received by the editors October 7, 1996 and, in revised form, February 10, 1998. 1991 Mathematics Subject Classification. Primary 54A35; Secondary 54B20, 54C60.
The Cancer Prevention and Control Research Network

The Cancer Prevention and Control Research Network is a national network recently established to focus on developing new interventions and disseminating and translating proven interventions into practice to reduce cancer burden and disparities, especially among minority and medically underserved populations. Jointly funded by the Centers for Disease Control and Prevention and the National Cancer Institute, the Cancer Prevention and Control Research Network consists of sites administered through Prevention Research Centers funded by the Centers for Disease Control and Prevention. The five sites are located in Kentucky, Massachusetts, South Carolina, Texas, Washington State, and West Virginia. The Cancer Prevention and Control Research Network's intervention areas include primary prevention of cancer through healthy eating, physical activity, sun avoidance, tobacco control, and early detection of cancer through screening. The Cancer Prevention and Control Research Network uses the methods of community-based participatory research and seeks to build on the cancer-relevant systematic reviews of the Guide to Community Preventive Services. Initial foci for the Cancer Prevention and Control Research Network's research work groups include projects to increase screening for breast, cervical, and colorectal cancers; to promote informed decision making for prostate cancer screening; and to validate educational materials developed for low-literacy populations.
Subsurface sediment remobilization and fluid flow in sedimentary basins: an overview

Subsurface sediment remobilization and fluid flow processes and their products are increasingly being recognized as significant dynamic components of sedimentary basins. The geological structures formed by these processes have traditionally been grouped into mud volcano systems, fluid flow pipes and sandstone intrusion complexes. But the boundaries between these groups are not always distinct because there can be similarities in their geometries and the causal geological processes. For instance, the process model for both mud and sand remobilization and injection involves a source of fluid that can be separate from the source of sediment, and diapirism is now largely discarded as a deformation mechanism for both lithologies. Both mud and sand form dykes and sills in the subsurface and extrusive edifices when intersecting the sediment surface, although the relative proportions of intrusive and extrusive components are very different, with mud volcano systems being largely extrusive and sand injectite systems being mainly intrusive. Focused fluid flow pipes may transfer fluids over hundreds of metres of vertical section for millions of years and may develop into mud volcano feeder systems under conditions of sufficiently voluminous and rapid fluid ascent associated with deeper focus points and overpressured aquifers. Both mud and sand remobilization is facilitated by overpressure and generally will be activated by an external trigger such as an earthquake, although some mud volcano systems may be driven by the re‐charge dynamics of their fluid source. Future research should aim to provide spatio‐temporal ‘injectite’ stratigraphies to help constrain sediment remobilization processes in their basinal context and identify and study outcrop analogues of mud volcano feeders and pipes, which are virtually unknown at present. Further data‐driven research would be significantly boosted by numerical and analogue process modelling to constrain the mechanics of deep subsurface sediment remobilization as these processes can not be readily observed, unlike many conventional sediment transport phenomena.
New Roles of Phytochromes during Seed Germination

Among the most important environmental sensors in plants are the phytochromes, members of a duplicated‐gene family of photoreceptors. We characterized the functional diversification of this gene family with respect to a single ecologically important and highly environmentally sensitive process—germination—and thereby addressed the consequence of gene duplication in the evolution of environmental sensitivity. We exposed single and multiple mutants of different phytochromes of Arabidopsis thaliana to dormancy‐breaking or dormancy‐inducing treatments that resemble different seasonal environmental conditions, and we recorded their germination responses. Much redundancy of function occurred, but an impressive degree of functional diversification was also apparent. Specifically, PHYB was an important contributor to germination when seeds did not receive low‐temperature imbibition. It interacted nonadditively with PHYA, whose contribution to germination was redundant to that of PHYB and most apparent when seeds experienced high followed by low temperatures. We also determined that PHYD was necessary for full germination when seeds were exposed to a high temperature during imbibition. PHYE appears to contribute redundantly to germination, except when seeds experienced high followed by low temperatures. Finally, we found new evidence that PHYA and possibly PHYD redundantly contribute to the suppression of germination. The diversification of activities of all these phytochromes during this one process of germination suggests that they all have a combined function in the regulation of germination responses to complex seasonal conditions and that gene duplication can contribute to the evolution of precise responses to variable environments.
From the ground up: information needs of nurses in a rural public health department in Oregon.

OBJECTIVES The research identified and assessed information needs and resources of public health nurses in a local health department. METHODS Semi-structured in-depth interviews were conducted with seventeen public health nurses at a local health department in rural Oregon. Interview transcripts were analyzed using a constant comparative method to assess the information nurses sought and used in their work. RESULTS Public health nurses performed a wide variety of roles and associated tasks. Major themes that emerged from analyses of interview transcripts included: (1) differences in information needs depending on position and role; (2) colleagues as the most efficient and trusted source of information; (3) limitations of existing knowledge-based resources; (4) need for up-to-date and pertinent information; and (5) need for personal computers, basic communications software, and expanded Internet access. CONCLUSIONS Lack of Internet access is a significant barrier to use of information resources, and information tools tailored to meet the needs diverse public health nursing roles and facilitate information sharing among colleagues are needed. Librarians and informaticians can assist by addressing these needs and improving the organization of content and interface design for commonly used websites.
Role of zoledronic acid in the prevention and treatment of osteoporosis

Taken once a year, intravenous zoledronic acid (Zol) (Reclast® or Aclasta®) is a third-generation nitrogen-containing bisphosphonate that is effective compared with placebo in reducing the risk of fractures in patients with postmenopausal osteoporosis and recent low-trauma hip fracture. In glucocorticoid-induced osteoporosis, there is no significant difference between Zol and risedronate for new fractures. Improvements in bone mineral density and early reduction of bone remodeling markers are observed in postmenopausal osteoporosis, recent low-trauma hip fracture, and glucocorticoid-induced osteoporosis. Given that Zol is generally well tolerated and very convenient, it is an interesting therapeutic option for aging patients who take multiple oral drugs, who have adherence or gastrointestinal tolerance issues, and who have an indication for oral bisphosphonates. Zol is not recommended for patients with severe renal impairment. Vitamin D deficiency should be corrected before the administration of Zol.
Specialization Can Drive the Evolution of Modularity

Organismal development and many cell biological processes are organized in a modular fashion, where regulatory molecules form groups with many interactions within a group and few interactions between groups. Thus, the activity of elements within a module depends little on elements outside of it. Modularity facilitates the production of heritable variation and of evolutionary innovations. There is no consensus on how modularity might evolve, especially for modules in development. We show that modularity can increase in gene regulatory networks as a byproduct of specialization in gene activity. Such specialization occurs after gene regulatory networks are selected to produce new gene activity patterns that appear in a specific body structure or under a specific environmental condition. Modules that arise after specialization in gene activity comprise genes that show concerted changes in gene activities. This and other observations suggest that modularity evolves because it decreases interference between different groups of genes. Our work can explain the appearance and maintenance of modularity through a mechanism that is not contingent on environmental change. We also show how modularity can facilitate co-option, the utilization of existing gene activity to build new gene activity patterns, a frequent feature of evolutionary innovations.
Pies with EYEs: the limits of hierarchical pie menus in gaze control

Pie menus offer several features which are advantageous especially for gaze control. Although the optimal number of slices per pie and of depth layers has already been established for manual control, these values may differ in gaze control due to differences in spatial accuracy and congitive processing. Therefore, we investigated the layout limits for hierarchical pie menu in gaze control. Our user study indicates that providing six slices in multiple depth layers guarantees fast and accurate selections. Moreover, we compared two different methods of selecting a slice. Novices performed well with both, but selecting via selection borders produced better performance for experts than the standard dwell time selection.
An investigation of radiation damage in rat lungs following dual-energy micro-CT imaging

Dual-energy micro-CT imaging techniques have been developed to enable accurate identification and segmentation of different tissues. Using dual-energy techniques for thoracic imaging requires obtaining images at multiple respiratory or cardiac phases, and may require images obtained pre- and post-contrast enhancement for each energy. In this study, we investigated if the multiple images obtained during dual-energy imaging resulted in an x-ray dose sufficiently high to interfere with or mask symptoms of respiratory disease. We performed a dual-energy micro-CT study (5 images in a single session, with a cumulative entrance dose of 0.47 Gy) to image the thorax of healthy male Brown Norway rats at 8 weeks of age. Groups of 5 rats were euthanized at 1 day, 1, 2, 3, and 4-weeks post-exposure and the lungs were excised and examined by histology (H&E stained slides). Positive controls were exposed to an entrance dose of 1.5 Gy and euthanized at 2 weeks and negative controls were not exposed to x-rays. There was no evidence of alveolar damage or inflammation for any of the animals exposed to the dual-energy imaging session compared with the negative control group. Inflammation was evident for the positive controls. This study concludes that the dual-energy imaging protocol developed in this study does not contribute to lung tissue damage. For preclinical respiratory research, these results show that any inflammation and alveolar damage observed in the lungs would be attributed to the disease model under investigation, and not be affected by obtaining 3D dual-energy micro-CT images.
Gender differences in the occurrence of farm related injuries.

AIMS To use national surveillance data in Canada to describe gender differences in the pattern of farm fatalities and severe injuries (those requiring hospitalisation). METHODS Data from the Canadian Agricultural Injury Surveillance Program (CAISP) included farm work related fatalities from 1990 to 1996 for all Canadian provinces and abstracted information from hospital discharge records from eight provinces for the five fiscal years of 1990 to 1994. Gender differences in fatalities and injuries were examined by comparison of proportions and stratified by sex, injury class (machinery, non-machinery), and age group. RESULTS Over the six year period of 1990 to 1996 there were approximately 11 times as many agriculture related fatalities for males compared to females (655 and 61, respectively). The most common machinery mechanisms of fatal injuries were roll-over (32%) for males and run-over (45%) for females. Agricultural machinery injuries requiring hospitalisation showed similar patterns, with proportionally more males over age 60 injured. The male:female ratio for non-machinery hospitalisations averaged 3:1. A greater percentage of males were struck by or caught against an object, whereas for females, animal related injuries predominated. CONCLUSIONS Gender is an important factor to consider in the interpretation of fatal and non-fatal farm injuries. A greater number of males were injured, regardless of how the occurrence of injury was categorised, particularly when farm machinery was involved. As women increasingly participate in all aspects of agricultural production, there is a need to collect, interpret, and disseminate information on agricultural injury that is relevant for both sexes.
Deep learning with convolutional neural networks for decoding and visualization of EEG pathology

We apply convolutional neural networks (ConvNets) to the task of distinguishing pathological from normal EEG recordings in the Temple University Hospital EEG Abnormal Corpus. We use two basic, shallow and deep ConvNet architectures recently shown to decode task-related information from EEG at least as well as established algorithms designed for this purpose. In decoding EEG pathology, both ConvNets reached substantially better accuracies (about 6% better, ≈85% vs. ≈79%) than the only published result for this dataset, and were still better when using only 1 minute of each recording for training and only six seconds of each recording for testing. We used automated methods to optimize architectural hyperparameters and found intriguingly different ConvNet architectures, e.g., with max pooling as the only nonlinearity. Visualizations of the ConvNet decoding behavior showed that they used spectral power changes in the delta (0–4 Hz) and theta (4–8 Hz) frequency range, possibly alongside other features, consistent with expectations derived from spectral analysis of the EEG data and from the textual medical reports. Analysis of the textual medical reports also highlighted the potential for accuracy increases by integrating contextual information, such as the age of subjects. In summary, the ConvNets and visualization techniques used in this study constitute a next step towards clinically useful automated EEG diagnosis and establish a new baseline for future work on this topic.
The Hybrid Effect of Jute/Kenaf/E-Glass Woven Fabric Epoxy Composites for Medium Load Applications: Impact, Inter-Laminar Strength, and Failure Surface Characterization

ABSTRACT This research has been carried out to find better hybrid natural/glass fiber-reinforced composites for engineering applications. This research work studied the impact and inter-laminar strength of E-glass with jute/kenaf woven fabric epoxy composites with the aim of evaluating the hybridization effects on different laminate stacking sequences made with jute, kenaf, and E-glass fabrics by the vacuum bagging method. All the laminates were prepared in 300 × 300 mm2 with a total of five plies maintained at 3 mm thickness, by varying the number and position of jute, kenaf, glass layers so as to obtain nine different stacking sequences. Among them, one group of all pure jute, pure kenaf, and pure E-glass laminates were also fabricated for comparison purpose. The specimen preparation and testing were carried out as per ASTM standards. From the results, it is shown that the properties of jute/kenaf fabrics-reinforced epoxy composites can be enhanced by hybridization with the addition of glass fabrics. The hybridization of jute/kenaf fabrics with E-glass fabrics provides a method to improve the mechanical impact and inter-laminar strength over pure natural fiber-reinforced composites. The hybrid laminate having E-glass and kenaf fiber plies as skin layers and jute fiber plies as core layers showed better properties compared to other laminates.
Stochastic models of the meridional overturning circulation: time scales and patterns of variability

The global meridional overturning circulation (MOC) varies over a wide range of space and time scales in response to fluctuating ‘weather’ perturbations that may be modelled as stochastic forcing. This study reviews model studies of the effects of climate noise on decadal to centennial MOC variability, on transitions between the MOC regimes and on the dynamics of Dansgaard–Oeschger events characteristic of glacial periods.