Miracle-dz/UniFAR-FTUs huggingface dataset:
Multicomponent transport impact on turbulent premixed H2/O2 flames

We investigate the impact of multicomponent transport on premixed turbulent H2/O2 flames. The present direct numerical simulation (DNS) database contains 15 flame configurations where freely propagating planar flames interact with counter-rotating vortices and synthetic turbulence fields. The DNS solver considers the conservation equations for species, momentum and energy with complex chemistry and detailed transport in two space dimensions and in the low Mach number regime. Accurate transport algorithms accounting for both multicomponent molecular and thermal diffusion are implemented in this solver at low computational costs. Multicomponent transport may lead locally in space or time to substantial modifications of turbulent flame properties. These modifications can be much larger than those observed for laminar flames. They are particularly noticeable on the propagation velocity and thus on the stretch in regions where the flame front experiences strong curvature effects. For most flames studied here, multicomponent transport has only a moderate impact on global flame properties because of the smoothing induced by turbulent fluctuations. Thus, the present DNS results, which for the first time incorporate detailed transport models, provide a form of a posteriori validation for previous DNS based on simplified transport models. However, for highly curved flames or when quenching phenomena arise, multicomponent transport plays a sufficiently relevant role to be included in accurate DNS. (Some figures in this article are in colour only in the electronic version; see www.iop.org)
"Still sounds like a rainbow"-a proposal for a coloured vowel chart

The present contribution aims at reinvestigating the idea of sound-colour charts with a view to enhancing L2 pronunciation training through relying on sound and colour perceptual correspondence. A preliminary proposal for a coloured vowel chart is put forward, in which the assignment of colours corresponds to the general tendencies resulting from cross-modal studies on vowel and colour associations in English (Wrembel & Rataj to appear) and Polish (the present study). The expected outcome of the investigation is to develop a system of mapping perceptual attributes between audio and visual senses that would function as a pedagogical aid based on the idea of multimodal reinforcement.
An Efficient Hybrid Algorithm for Nurse Rostering Problem

Nurse rostering is a difficult search problem with many constraints. In the literature, a number of approaches have been investigated including penalty function methods to tackle these constraints within genetic algorithm frameworks. In this paper, we investigate an extension of a previously proposed stochastic ranking method, which has demonstrated superior performance to other constraint handling techniques when tested against a set of constrained optimisation benchmark problems. An initial experiment on nurse rostering problems demonstrates that the stochastic ranking method is better in finding feasible solutions but fails to obtain good results with regard to the objective function. To improve the performance of the algorithm, we hybridise it with a recently proposed simulated annealing hyper-heuristic within a local search and genetic algorithm framework. The hybrid algorithm shows significant improvement over both the genetic algorithm with stochastic ranking and the simulated annealing hyper-heuristic alone. The hybrid algorithm also considerably outperforms the methods in the literature which have the previously best known results.
Optimal wavelet differencing method for robust motion detection

In real-world surveillance systems, where variation of light and camera parameters can sometimes severely impair the normal operation of background subtraction algorithms, better results are obtained with differencing schemes. We have earlier demonstrated that differencing of detail images produced by wavelet transformation can lead to more stable detection results. In this paper, we considerably extend that framework, by introducing the modified z-scores calculated from wavelet coefficient differences. Foreground pixels are detected as outliers in normal distribution by modified z-score test. The threshold value used in the outlier test is optimized by maximizing the precision and recall measures on several training frames. Finally, the elimination of ghosts from motion detection is done by double modified z-score testing, that is similar in idea to double frame differencing. The resulting motion detection method shows considerable resilience to changes in illumination and camera parameters and also produces a lower amount of detection errors than other motion detection methods.
The Single Period Inventory and Pricing Problem with Spectral Risk Measures

Inventory management decisions based on quantitative models both in industrial practice and academic works often rely on minimizing expected cost or maximizing expected revenues or profits, which refers to the concept of risk-neutrality of the decision maker. Although many useful insights in operational problems can be obtained by such an approach, it is well understood that incorporating attitudes toward risk is an important lever for building new theories in other fields such as economics and finance. The level of risk associated with an investment might be as important as the expected gain from the investment. Hence, it is necessary to find appropriate measures of risk and the appropriate objectives related to or including these risk measures for inventory control problems. After the axiomatic foundation of coherent risk measures the application of risk measures to inventory models such as Conditional Value-at-Risk (CVaR) or convex combinations of mean and CVaR became popular. In our work we apply spectral risk measures to the single-period, single-item, linear cost inventory control problem (also known as newsvendor problem) and derive optimal policies. By doing so, we are able to unify results obtained so far in the literature under the common concept of spectral risk measures for the case of zero and non-zero shortage penalty cost. In particular, we show convexity results and structural properties for the inventory control problem. An extensive numerical analysis illustrates the findings.
Analysis of phase transitions in the mean-field Blume–Emery–Griffiths model

In this paper we give a complete analysis of the phase transitions in the mean-field Blume–Emery–Griffiths lattice-spin model with respect to the canonical ensemble, showing both a second-order, continuous phase transition and a first-order, discontinuous phase transition for appropriate values of the thermodynamic parameters that define the model. These phase transitions are analyzed both in terms of the empirical measure and the spin per site by studying bifurcation phenomena of the corresponding sets of canonical equilibrium macrostates, which are defined via large deviation principles. Analogous phase transitions with respect to the microcanonical ensemble are also studied via a combination of rigorous analysis and numerical calculations. Finally, probabilistic limit theorems for appropriately scaled values of the total spin are proved with respect to the canonical ensemble. These limit theorems include both central-limit-type theorems, when the thermodynamic parameters are not equal to critical values, and noncentral-limit-type theorems, when these parameters equal critical values.
Correlation Between Work-Family Conflict, Marital Satisfaction And Job Satisfaction

Work and family problems are important in the life of a nurse that causes conflict between work and family. This work-family conflict requires satisfaction in marriage and satisfaction in work. The purpose of this study is to examine the relationship between work-family conflict with marital satiction and between work-family conflict and job satisfaction. This research is survey research. The population in this study were nurses who worked in hospital X in Purwokerto with a sample of 40 people (men = 6 people and 34 women). The instruments used in this study were the scale of work-family conflict, the scale of job satisfaction and scale of marital satisfaction. The results of the data analysis showed a negative and significant contradiction between work-family conflict and marital satisfaction. This means that the higher the workfamily conflict, the lower the marital satisfaction. The same results were also found in conflicts between family work and job satisfaction, namely, there were those who argued negatively and significantly between family work conflicts and job satisfaction. These results can explain how roles in the family and workplace influence each other. Therefore, nurses must balance roles in the family and roles in the workplace to reduce family conflict. Decreased workfamily conflict will ultimately increase satisfaction in marriage and satisfaction in the workplace.
EGFR, PIK3CA, KRAS and BRAF mutations in meningiomas

Meningiomas are among the most frequent intracranial tumors. Treatment involves surgical resection with optional subsequent radiotherapy for high-grade meningiomas or radiosurgery following incomplete tumor removal. At present, no pharmacological agents are used as treatment. The use of targeted therapies has been considered, and specific therapies, including anti-EGFR treatment, have been clinically tested. The experience from the treatment of various types of cancers shows that patient outcome depends on the mutational status of particular molecules, including epithelial growth factor receptor (EGFR), Kirsten rat sarcoma viral oncogene homolog (KRAS), v-Raf murine sarcoma viral oncogene homolog B1 (BRAF) and phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit α (PIK3CA). Therefore, the aim of the present study was to assess the occurrence and potential use of these markers in patients with meningioma. In total, 55 formalin-fixed, paraffin-embedded meningioma samples were subjected to genomic sequencing of EGFR (exons 18–21), KRAS (exon 1), BRAF (exon 15) and PI3K (exons 9, 20). No mutations were identified in EGFR, KRAS or BRAF. Point mutations in PIK3CA were revealed in the samples of two patients with atypical and anaplastic meningiomas. Although these mutations appear to be rare, this result, along with previously reported findings, indicates that the PI3K/protein kinase B pathway may serve as a more reasonable molecular target for meningioma than EGFR.
Alterations in Left Ventricular Three‐dimensional Dynamic Geometry and Systolic Function During Acute Right Ventricular Hypertension in the Conscious Dog

Fifteen chronically instrumented, conscious dogs were studied to determine whether, in the intact circulation, mechanical interactions dictated by the anatomic contiguity of the two ventricles significantly alter left ventricular (LV) dynamic geometry and systolic function during acute right ventricular (RV) hypertension. The three-dimensional geometry of the left ventricle was monitored with three pairs of ultrasonic dimension transducers; ventricular pressures were measured with micromanometers. Data collected during pulmonary artery constriction (RV pressure 68 ± 8/7 ± 4 mm Hg) were compared with control data collected at matched heart rates (RV pressure 32 ± 8/4 ± 4mm Hg). During pulmonary artery constriction, mean calculated LV end-diastolic volumes decreased from 69.2 ± 20.0 to 56.2 ± 21.3 cm3 (p s 0.05). Mean systolic stroke volume decreased from 20.6 5.5 to 14.0 6.3 cm3 (p % 0.05). These changes were entirely accounted for by alterations in the behavior of the LV septal-free wall minor axis and rearrangements in LVequatorial geometry. When the pulmonary artery was constricted, elongation of the septal-free wall axis occurred during isovolumic systole and was accompanied by a reciprocal decrease in anterior-posterior dimension. Most of the decrease in septal-free wall dimension occurred during relaxation and early diastole rather than during ejection. Mean septal-free wall end-diastolic dimension decreased from 5.45 ± 0.69 to 4.90 ± 0.75 cm (p S 0.05). The mean systolic decrease in septal-free wall dimension fell from 0.36 ± 0.18 to 0.14 ± 0.22 cm (p S 0.05). The end-diastolic dimensions and systolic shortening of the LV anterior-posterior minor axis and base-apex major axis were not significantly altered by pulmonary artery constriction. These findings suggest that during acute RV hypertension, impairment of LV systolic function and rearrangements in LV dynamic geometry are primarily the result of the anatomic contiguity of the two ventricles.
Ectopic Expression of WUS in Hypocotyl Promotes Cell Division via GRP23 in Arabidopsis

WUSCHEL (WUS) is essential for preventing stem cell differentiation in Arabidopsis . Here we report that in addition to its functions in meristematic stem cell maintenance, WUS is involved in the regulation of cell division. The WUS gain-of-function mutant, stem ectopic flowers (sef), displayed elongated hypocotyls, whereas the loss-of-function wus-1 mutant had shortened hypocotyls. The long hypocotyl in sef was due to the presence of more cells, rather than increased cell elongation. Microscopic observation, flow cytometry assays, quantitative RT-PCR (qRT-PCR), and histochemical staining of CycB1;1::GUS supported the hypothesis that ectopic cell division occurred in the sef hypocotyls after germination. Both immunoblot and qRT-PCR results showed that WUS was ectopically expressed in sef hypocotyls. Luciferase activity, chromatin immunoprecipitation (ChIP) and electrophoretic mobility shift assay (EMSA) showed that GLUTAMINE-RICH PROTEIN 23 (GRP23) expression can be activated by WUS and that GRP23 is a direct target gene of WUS. The phenotypes of 35S::GRP23 plants and GRP23 knockdown lines supported the notion that GRP23 mediates the effects of WUS on hypocotyl length. Together, our data suggest that ectopic expression of WUS in hypocotyl controls cell division through its target gene GRP23.
Your server as a function

Building server software in a large-scale setting, where systems exhibit a high degree of concurrency and environmental variability, is a challenging task to even the most experienced programmer. Efficiency, safety, and robustness are paramount---goals which have traditionally conflicted with modularity, reusability, and flexibility. We describe three abstractions which combine to present a powerful programming model for building safe, modular, and efficient server software: Composable futures are used to relate concurrent, asynchronous actions; services and filters are specialized functions used for the modular composition of our complex server software. Finally, we discuss our experiences using these abstractions and techniques throughout Twitter's serving infrastructure.
Coral reefs may start dissolving when atmospheric CO2 doubles

Calcification rates in stony corals are expected to decline significantly in the near future due to ocean acidification. In this study we provide a global estimate of the decline in calcification of coral reefs as a result of increase in sea surface temperature and partial pressure of CO2. This estimate, unlike previously reported estimates, is based on an empirical rate law developed from field observations for gross community calcification as a function of aragonite degree of saturation (Ωarag), sea surface temperature and live coral cover. Calcification rates were calculated for more than 9,000 reef locations using model values of Ωarag and sea surface temperature at different levels of atmospheric CO2. The maps we produced show that by the time atmospheric partial pressure of CO2 will reach 560 ppm all coral reefs will cease to grow and start to dissolve.
Applications of BMI or BSI: Differences and Revisions According to Age and Height

Validation of body-mass relationships requires a careful statistical analysis of data of normal weight individuals. BMI (ratio between body mass and square of body height) and BSI values (ratio between mass and cube of body height) have been calculated for 99 persons with ages between 1 day and 76 years. These BMI or BSI values have been used for least squares fits yielding mean BMI or BSI values, their variances (providing precision), and average deviations of individual BMI/BSI values from the BMI/BSI means. The latter allows limits to over- and underweight. For adults we found mean values of BSI of 12.36 and confirmed 21.7 for the mean BMI; but the BSI was 1.4 times more precise than the BMI. For children shorter than 1.3 m and younger than 8 years we found the BMI average of 15.9 and over-/underweight limits of 17.4/14.4 being significantly smaller than and incompatible with the recommended BMI values.
A Novel Hybrid Yeast-Human Network Analysis Reveals an Essential Role for FNBP1L in Antibacterial Autophagy 1

Autophagy is a conserved cellular process required for the removal of defective organelles, protein aggregates, and intracellular pathogens. We used a network analysis strategy to identify novel human autophagy components based upon the yeast interactome centered on the core yeast autophagy proteins. This revealed the potential involvement of 14 novel mammalian genes in autophagy, several of which have known or predicted roles in membrane organization or dynamics. We selected one of these membrane interactors, FNBP1L (formin binding protein 1-like), an F-BAR-containing protein (also termed Toca-1), for further study based upon a predicted interaction with ATG3. We confirmed the FNBP1L/ATG3 interaction biochemically and mapped the FNBP1L domains responsible. Using a functional RNA interference approach, we determined that FNBP1L is essential for autophagy of the intracellular pathogen Salmonella enterica serovar Typhimurium and show that the autophagy process serves to restrict the growth of intracellular bacteria. However, FNBP1L appears dispensable for other forms of autophagy induced by serum starvation or rapamycin. We present a model where FNBP1L is essential for autophagy of intracellular pathogens and identify FNBP1L as a differentially used molecule in specific autophagic contexts. By using network biology to derive functional biological information, we demonstrate the utility of integrated genomics to novel molecule discovery in autophagy.
[Knowledge, attitudes and practice related to Papanicolaou smear test among Argentina's women].

OBJECTIVES To evaluate the knowledge, attitudes, and practice regarding the Papanicolaou test in an Argentinean community. METHODS Two hundred women were interviewed at their homes in Puerto Leoni, Misiones, Argentina. Women were selected by simple random sampling. Answers were described in terms of knowledge, attitudes, and practice, ant their respective adequacies with respect to the Papanicolaou test, as previously defined. Adequacy was compared between the categories of the control variables by chi2 test with a 5% significance level. RESULTS Knowledge and practice of the Papanicolaou test were adequate in 49.5% and 30.5% of subjects, respectively, although the attitude towards the test was considered adequate in 80.5% of subjects. Another important finding was that women reported as the main reason for not undergoing the test the lack of a request by a physician or healthcare professional. CONCLUSIONS Our results show a need for increasing the information provided to the public, especially by healthcare services and professionals, thus generating knowledge among the population of the advantages and benefits of Papanicolaou testing.
Cell Fate Specification and Symmetrical/Asymmetrical Divisions in the Developing Cerebral Cortex

Two different modes of cell division are adopted by progenitor cells to generate the neurons and glia of the cerebral cortex: they either divide symmetrically to generate other progenitors or a pair of postmitotic cells or divide asymmetrically to generate both a progenitor and a postmitotic cell. In this study we used a lineage marker, the BAG retrovirus, in embryonic day 16 rats in combination with bromodeoxyuridine (BrdU) to identify patterns of cell generation in the cerebral cortex, and investigated the relationship between the phenotype of cells and the history of their lineages. The location, phenotype and birth order of clonally related cells were studied in the subsequent 3 weeks. Only pyramidal neurons and/or astrocytes formed discrete clusters in which several generations of family members were present, whereas nonpyramidal neurons were found exclusively in pairs or as single cells. Analysis of BrdU levels in these cells showed that nonpyramidal neurons were originally part of larger clones and were found dispersed in the neocortex because of tangential migration of their progenitors, dispersion of postmitotic cells, or death of clonal relatives. These results suggest that both symmetrical and asymmetrical division can be adopted by progenitor cells to generate cortical neurons and glial cells and that cell extrinsic events contribute to the isolation of nonpyramidal neurons.
Incidence and Risk Factors of Retinopathy of Prematurity in Two Neonatal Intensive Care Units in North and South China

Background: To investigate the incidence and risk factors of retinopathy of prematurity (ROP) in two Neonatal Intensive Care Units in North and South of China, respectively. Methods: We studied data concerning 472 infants with gestational age (GA) ⩽34 weeks or birth weight (BW) ⩽2000 g who were admitted to the Zhujiang Hospital of Southern Medical University and the Fourth Hospital of Shijiazhuang between January 1, 2011 and December 31, 2011. Clinical information about perinatal neonates was collected and was confirmed by reviewing medical charts. The incidence and severity of ROP were assessed in the screened population. Main outcome measures are the incidence and severity of ROP. The relationship of clinical risk factors and the development of ROP were analyzed. Results: The overall incidence of ROP was 12.7%, and the overall incidence of type 1 ROP was 2.3%; 9.4% of infants in Zhujiang Hospital had ROP compared to 15.0% infants in the Fourth Hospital of Shijiazhuang developed ROP, and the difference is statistically significant. ROP was significantly associated with GA (odds ratio [OR]: 0.77 [0.62–0.95], P = 0.015), BW (OR: 0.998 [0.996–0.999], P = 0.008), maternal supplemental oxygen administration before and during delivery (OR: 4.27 [1.21–15.10], P = 0.024) and preeclampsia (OR: 6.07 [1.73–21.36] P = 0.005). The risk factors for ROP are different in two hospitals. In Zhujiang Hospital, BW is the independent risk factors for ROP while GA, BW and preeclampsia in the Fourth Hospital in Shijiazhuang Conclusions: Retinopathy of prematurity incidence is different based on area. Incidence of ROP is still high in China. More efforts need to prevent ROP.