Miracle-dz/UniFAR-FTUs huggingface dataset:
Escalation of competition into conflict in competitive networks of Formula One drivers

Significance Competition, while often seen as beneficial, can escalate into destructive conflict. This occurs, for instance, when athletes sabotage each other or when rival executives get caught up in a career-derailing fight. These escalations into conflict are especially likely among status-similar competitors, who are fraught with discordant understandings of who is superior to whom. We examine the link between status similarity and conflict as well as the conditions under which this link holds. We find that status-similar Formula One drivers are more prone to collide, especially when they are age-similar, perform well, are embedded in a stable role structure, and feel safe. Our inquiry deepens our understanding of when violent conflict emerges and can guide conflict prevention efforts. This article investigates the factors that escalate competition into dangerous conflict. Recent sociological theorizing claims that such escalations are particularly likely in dyads of structurally equivalent people (i.e., actors who have the same relations with the same third parties). Using panel data on Formula One races from 1970 through 2014, we model the probability that two drivers collide on the racetrack (an observable trace of conflict) as a function of their structural equivalence in a dynamic network of competitive relationships. Our main hypothesis, that the likelihood of conflict rises with structural equivalence, receives empirical support. Our findings also show that the positive association between structural equivalence and conflict is neither merely a matter of contention for official position nor an artifact of inherently hostile parties spatially exposed to each other. Our analyses further reveal that this positive association is concentrated in a number of theoretically predictable conditions: among age-similar dyads, among stronger performers, in stable competitive networks, and in safe, rather than dangerous, weather conditions. Implications for future research on conflict, networks, and tournaments are discussed.
The role of ultralarge multimers in recombinant human von Willebrand factor – a review of physico-and biochemical studies and findings in in vivo models and in humans with von Willebrand disease

Summary Ultralarge multimers (ULM) of VWF are considered to be the most active with respect to binding to platelets and to subendothelial structures and therefore are of critical importance for the function of VWF in stabilizing the primary hemostatic plug. In contrast to plasma-derived FVIII-VWF concentrates, human rVWF obtained from mammalian cell culture retains the full-spectrum of intact multimers, including ULM, as physiologically formed in the Golgi apparatus and stored in platelet α-granules and endothelial cell Weibel–Palade bodies. In the course of physico and biochemical, functional and animal studies, rVWF exhibited superiority in structure and function compared to pdVWF. These effects seemed to correlate with the multimer size and therefore might be attributed to the presence of ULM in rVWF preparations. The pharmacokinetic (PK), safety and efficacy characteristics seen in preclinical studies were further demonstrated in clinical trials.
Using Computerized Mental Health Programs in Alternative Education: Understanding the Requirements of Students and Staff

ABSTRACT Computerized cognitive behavioral therapy (cCBT) programs have been shown to be both acceptable and effective with youth. However, their use with more vulnerable youth, such as early school leavers, remains relatively unstudied. This study explored student and staff attitudes toward the use of cCBT in an alternative education setting. Methods: Student and staff needs were assessed using the Requirements development approach (Van Velsen, Wentzel, & Van Gemert-Pijnen, 2013). An online staff survey (n = 16) was conducted to provide information on the context of delivery, and stakeholder requirements were further explored in four student workshops (n = 32) and staff group discussions (n = 12). Results: Students’ requirements in relation to program look and feel were reflective of issues with literacy and concentration. Activity- rather than text-based programs were considered easier to learn from, whereas attractive design with features such as connecting with others were thought necessary to keep young people engaged. Students wanted to learn practical skills on improving their mental health and well-being, using content that is positive, encouraging, and credible and that can be tailored to individual needs. Anonymity and voluntary participation were considered essential when delivering cCBT in the context of alternative education, as well as additional access from home to ensure timeliness of support. Staff required both flexibility and careful planning and timetabling in order to deliver cCBT in the alternative education setting and to support student engagement. Conclusion: The findings provide novel insight into the needs and preferences of vulnerable youth, with important implications for the implementation of computerized mental health programs in alternative education settings. A better understanding of user needs and preferences is critical for improving the uptake and impact of e-mental health resources.
The role of the outer membrane protein gene ybjX in the pathogenicity of avian pathogenic Escherichia coli

ABSTRACT Avian pathogenic Escherichia coli (APEC) are important pathogens that cause serious economic losses to the poultry industry worldwide. The PhoP/Q system is essential for APEC pathogenicity, and its mutation leads to a decrease in ybjX gene expression, but whether ybjX regulated by PhoP/Q plays a role in pathogenicity remains unclear. The role of ybjX in APEC pathogenicity was investigated using a ybjX mutant strain constructed from APEC strain AE17 by the Red recombination method. The mutant strain displayed significantly reduced adherence to and invasion of chicken embryo fibroblast cell line (DF-1) cells. Moreover, N-phenyl-1-naphthylamine (NPN) assays revealed an increase in outer membrane permeabilization for the ybjX mutant, suggesting ybjX affected susceptibility to avian beta-defensin through this mechanism. The ybjX mutation increased susceptibility to avian beta-defensin 9 (AvBD9), and in vivo LD50 assays revealed reduced bacterial virulence in a chicken model. Taken together, these results indicated that mutation of ybjX may attenuate APEC pathogenicity, not only by affecting bacterial adhesion and invasion, but also via reducing resistance to avian beta-defensin by increasing outer membrane permeabilization of bacteria.
LEGO: Learning Edge with Geometry all at Once by Watching Videos

Learning to estimate 3D geometry in a single image by watching unlabeled videos via deep convolutional network is attracting significant attention. In this paper, we introduce a "3D as-smooth-as-possible (3D-ASAP)" prior inside the pipeline, which enables joint estimation of edges and 3D scene, yielding results with significant improvement in accuracy for fine detailed structures. Specifically, we define the 3D-ASAP prior by requiring that any two points recovered in 3D from an image should lie on an existing planar surface if no other cues provided. We design an unsupervised framework that Learns Edges and Geometry (depth, normal) all at Once (LEGO). The predicted edges are embedded into depth and surface normal smoothness terms, where pixels without edges in-between are constrained to satisfy the prior. In our framework, the predicted depths, normals and edges are forced to be consistent all the time. We conduct experiments on KITTI to evaluate our estimated geometry and CityScapes to perform edge evaluation. We show that in all of the tasks, i.e. depth, normal and edge, our algorithm vastly outperforms other state-of-the-art (SOTA) algorithms, demonstrating the benefits of our approach.
Anaemia among pregnant Palestinian women in the Occupied Palestinian Territory

Abstract Objective To assess anaemia prevalence and correlated social and biological determinants among pregnant women in the Occupied Palestinian Territory (oPt). Design A cross-sectional survey conducted among pregnant women attending/accessing UNRWA (United Nations Relief and Works Agency for Palestine Refugees in the Near East) health centres in the Gaza Strip and the West Bank in September and October 2006. Setting Fifty-five UNRWA health centres in the oPt (eighteen in the Gaza Strip and thirty-seven in the West Bank). Subjects A random sample of 1740 pregnant women. Results Overall anaemia prevalence was 38·6 % (95 % CI 36·3, 40·9 %). A substantial difference in anaemia prevalence was observed between the Gaza Strip and the West Bank (44·9 % v. 31·1 %, respectively), as well as a significant increase in anaemia prevalence in the Gaza Strip compared with an Agency-wide survey conducted in 2004 (44·9 % v. 35·7 %, respectively). Anaemia prevalence was found to increase with age, parity and trimester of gestation. Conclusions Anaemia still appears to be a public health problem among pregnant women in spite of UNRWA interventions. The West Bank shows prevalence rates similar to those observed in neighbouring countries, while the Gaza Strip has higher rates. Prevalence rates of anaemia among pregnant Palestinian women are more than two times higher than those observed in Europe.
Pursuits: spontaneous interaction with displays based on smooth pursuit eye movement and moving targets

Although gaze is an attractive modality for pervasive interactions, the real-world implementation of eye-based interfaces poses significant challenges, such as calibration. We present Pursuits, an innovative interaction technique that enables truly spontaneous interaction with eye-based interfaces. A user can simply walk up to the screen and readily interact with moving targets. Instead of being based on gaze location, Pursuits correlates eye pursuit movements with objects dynamically moving on the interface. We evaluate the influence of target speed, number and trajectory and develop guidelines for designing Pursuits-based interfaces. We then describe six realistic usage scenarios and implement three of them to evaluate the method in a usability study and a field study. Our results show that Pursuits is a versatile and robust technique and that users can interact with Pursuits-based interfaces without prior knowledge or preparation phase.
Safety of lymphadenectomy during video-assisted thoracic surgery lobectomy: analysis from a national database†

OBJECTIVES The Italian VATS Group database was accessed to evaluate whether preoperative and intraoperative factors may affect the safety of lymphadenectomy (LA) during video-assisted thoracic surgery lobectomy. METHODS All video-assisted thoracic surgery lobectomy procedures performed between 1 January 2014 and 30 March 2017 for non-small-cell lung cancer with cN0 or cN1 disease were identified in the database. LA safety was evaluated based on intraoperative (operative time, bleeding and conversion rate) and postoperative (30-day morbidity and mortality, chest drain duration and length of stay) outcomes and was correlated with the number of resected lymph nodes and the rates of nodal upstaging. Continuous variables were presented as mean ± standard deviation and compared using the unpaired t-test; the χ2 test was used for categorical variables. Univariable analysis was performed on selected variables. Significant variables (P < 0.30) were entered into a Cox multivariable logistic regression model, using the overall and specific occurrence of complications as dependent variables. The Spearman's rank correlation coefficient was applied as needed. RESULTS A total of 3181 cases (2077 men, 65.3%; mean age of 69 years) met the enrolment criteria. Final pathology was consistent with adenocarcinoma (n = 2262, 67.5%), squamous cell (n = 520, 15.5%), typical (n = 184, 5.5%) and atypical carcinoid (n = 48, 1.4%) and other (n = 335, 10%). The mean number of resected lymph nodes was 13.42 ± 8.24; nodal upstaging occurred in 308 of 3181 (9.68%) cases. Six hundred and fifty-five complications were recorded in 404 (12.7%) patients; in this series, no mortality was observed. Univariable and multivariable analyses did not show any association between the extension of LA and intraoperative or postoperative outcomes. The number of resected lymph nodes and nodal upstagings showed a minimal correlation with intraoperative outcomes and a moderate correlation with postoperative air leak (ρ = 0.35 and ρ = 0.48, respectively), arrhythmia (ρ = 0.29 and ρ = 0.35, respectively), chest drain duration (ρ = 0.35 and ρ = 0.51, respectively) and length of stay (ρ = 0.35). CONCLUSIONS Based on the VATS Group data, video-assisted thoracic surgery LA proved to be safe and displayed good outcomes even when performed with an extended approach.
Mechanisms of immune regulation in allergic diseases: the role of regulatory T and B cells

Allergy is a major public health problem with a high socio‐economic impact. The number of allergic patients is expected to reach to four billion within two decades when the World's population reaches to 10 billion. Our knowledge on the molecular mechanisms underlying allergic diseases and allergen tolerance induction had significant advances during the last years. Nowadays, it is well accepted that the generation and maintenance of allergen‐specific regulatory T cells (Tregs) and regulatory B cells (Bregs) and the involvement of their suppressive cytokines and surface molecules are essential for the induction of allergen tolerance. These mechanisms play essential roles for the restoration of healthy immune responses to allergens in allergen‐specific immunotherapy (AIT) and healthy immune response during high‐dose antigen exposure in beekeepers and cat owners. AIT remains as the only disease‐modifying and curative treatment for allergic diseases and represents a perfect model to investigate the antigen‐specific immune responses in humans. A large number of clinical trials demonstrated AIT as an effective treatment in many patients, but it still faces several drawbacks in relation to efficacy, safety, long duration, and patient adherence. Novel strategies to overcome these inconveniences, such as the development of novel adjuvants and alternative routes of administration are being developed. The better understanding of the molecular mechanism governing the generation of Treg and Breg cells during allergen tolerance might well open new avenues for alternative therapeutic interventions in allergic diseases and help better understanding of other immune‐tolerance‐related diseases.
PROPOSED METHODOLOGY FOR PREDICTING HMA PERMEABILITY (WITH DISCUSSION)

Permeability is an important property that influences the performance of hot mix asphalt (HMA) mixes. It is a function of compaction effort, and several properties of HMA constituents such as asphalt content, size of aggregates and shape of aggregates. All these factors manifest themselves in different air void distributions, which in turn control fluid flow and permeability of asphalt mixes. The current practice is to relate measured permeability to the percent in-place air voids of HMA mixes. This paper relates HMA mix permeability to the three dimensional distribution of air voids. An innovative approach is developed to quantify air void connectivity, flow paths irregularity (Tortuosity), effective percent air voids, and specific surface area of air voids. This was made possible through X-ray computed tomography to capture the three-dimensional internal structure of HMA mixes and developing imaging techniques to analyze fluid flow paths. The developed methods were used to find the components of a modified expression for the Kozeny-Carman equation to predict HMA permeability depending on air void distribution properties only. The predicted permeability values had reasonable correlation with laboratory measurements. The permeability equation was further simplified to allow predicting permeability based on percent total air voids and aggregate gradation. This simplified equation was shown to have good correlation with laboratory and field measurements of permeability for HMA mixes with a wide range of properties.
A new method of onset and offset detection in ensemble singing

Abstract This paper presents a novel method combining electrolaryngography and acoustic analysis to detect the onset and offset of phonation as well as the beginning and ending of notes within a sung legato phrase, through the application of a peak-picking algorithm, TIMEX. The evaluation of the method applied to a set of singing duo recordings shows an overall performance of 78% within a tolerance window of 50 ms compared with manual annotations performed by three experts. Results seem very promising in light of the state-of-the-art techniques presented at MIREX in 2016 yielding an overall performance of around 60%. The new method was applied to a pilot study with two duets to analyse synchronization between singers during ensemble performances. Results from this investigation demonstrate bidirectional temporal adaptations between performers, and suggest that the precision and consistency of synchronization, and the tendency to precede or lag a co-performer might be affected by visual contact between singers and leader–follower relationships. The outcomes of this paper promise to be beneficial for future investigations of synchronization in singing ensembles.
Transfer Learning for Improving Speech Emotion Classification Accuracy

The majority of existing speech emotion recognition research focuses on automatic emotion detection using training and testing data from the same corpus collected under the same conditions. The performance of such systems has been shown to drop significantly in cross-corpus and cross-language scenarios. To address the problem, this paper exploits a transfer learning technique to improve the performance of speech emotion recognition systems that are novel in cross-language and cross-corpus scenarios. Evaluations on five different corpora in three different languages show that Deep Belief Networks (DBNs) offer better accuracy than previous approaches on cross-corpus emotion recognition, relative to a Sparse Autoencoder and Support Vector Machine (SVM) baseline system. Results also suggest that using a large number of languages for training and using a small fraction of the target data in training can significantly boost accuracy compared with baseline also for the corpus with limited training examples.
Long-term safety of tobramycin inhalation powder in patients with cystic fibrosis: phase IV (ETOILES) study

Abstract Objective: Long-term treatment with inhaled antibiotics is recommended for chronic Pseudomonas aeruginosa (Pa) infection in cystic fibrosis (CF) patients. The ETOILES study (Clinicaltrials.gov identifier: NCT01519661) evaluated the safety of tobramycin inhalation powder (TIP) for 1 year. Research design and methods: This single-arm, open-label, multicenter, phase IV trial, enrolled CF patients aged ≥6 years, with baseline FEV1 ≥25%–≤75% predicted and Pa infection, and assessed the safety of TIP over six cycles in terms of the incidence of treatment-emergent adverse events (AEs) and serious AEs (SAEs). Secondary endpoints included presence of airway reactivity, relative change in FEV1% predicted, and change in sputum Pa density (log10 colony forming units/g sputum). Results: A total of 157 patients were enrolled, and 96 patients (61.1%) completed the study. The most commonly reported AE was infective pulmonary exacerbation of CF (55.4%). Cough was reported as an AE in 23.6% of patients; a majority were mild or moderate and two were severe (1.3%). SAEs were reported by 31.2% of patients. No deaths were reported during the study. There were no clinically meaningful changes reported in airway reactivity. Most frequently reported post-inhalation event was cough at all time points; however, it was of short duration (<4 minutes) and decreased over the course of the study, possibly due to patients becoming more experienced with the administration of TIP. The post-inhalation events resolved without intervention in most cases. FEV1% predicted remained stable from Cycles 1 to 4 and tended to decrease thereafter, although it was not statistically significant (change from baseline to study end mean [SD] = −1.9% [14.55]; P = 0.199). Conclusions: This was one of the largest studies with long-term TIP exposure. The majority of patients enrolled were adults with more advanced CF lung disease than those in previous TIP studies. No new emerging safety signals were seen and efficacy was sustained during the year.
Gene Therapy for Pancreatic Cancer: Specificity, Issues and Hopes

A recent death projection has placed pancreatic ductal adenocarcinoma as the second cause of death by cancer in 2030. The prognosis for pancreatic cancer is very poor and there is a great need for new treatments that can change this poor outcome. Developments of therapeutic innovations in combination with conventional chemotherapy are needed urgently. Among innovative treatments the gene therapy offers a promising avenue. The present review gives an overview of the general strategy of gene therapy as well as the limitations and stakes of the different experimental in vivo models, expression vectors (synthetic and viral), molecular tools (interference RNA, genome editing) and therapeutic genes (tumor suppressor genes, antiangiogenic and pro-apoptotic genes, suicide genes). The latest developments in pancreatic carcinoma gene therapy are described including gene-based tumor cell sensitization to chemotherapy, vaccination and adoptive immunotherapy (chimeric antigen receptor T-cells strategy). Nowadays, there is a specific development of oncolytic virus therapies including oncolytic adenoviruses, herpes virus, parvovirus or reovirus. A summary of all published and on-going phase-1 trials is given. Most of them associate gene therapy and chemotherapy or radiochemotherapy. The first results are encouraging for most of the trials but remain to be confirmed in phase 2 trials.
Cancer initiating-cells are enriched in the CA9 positive fraction of primary cervix cancer xenografts

Numerous studies have suggested that Cancer Initiating Cells (CIC) can be identified/enriched in cell populations obtained from solid tumors based on the expression of cell surface marker proteins. We used early passage primary cervix cancer xenografts to sort cells based on the expression of the intrinsic hypoxia marker Carbonic Anhydrase 9 (CA9) and tested their cancer initiation potential by limiting dilution assay. We demonstrated that CICs are significantly enriched in the CA9+ fraction in 5/6 models studied. Analyses of the expression of the stem cell markers Oct4, Notch1, Sca-1 & Bmi1 showed a trend toward an increase in the CA9+ populations, albeit not significant. We present evidence that enhanced autophagy does not play a role in the enhanced growth of the CA9+ cells. Our study suggests a direct in vivo functional link between hypoxic cells and CICs in primary cervix cancer xenografts.