Miracle-dz/UniFAR-FTUs huggingface dataset:
What Box: A task for assessing language lateralization in young children

ABSTRACT The assessment of active language lateralization in infants and toddlers is challenging. It requires an imaging tool that is unintimidating, quick to setup, and robust to movement, in addition to an engaging and cognitively simple language processing task. Functional Transcranial Doppler Ultrasound (fTCD) offers a suitable technique and here we report on a suitable method to elicit active language production in young children. The 34-second “What Box” trial presents an animated face “searching” for an object. The face “finds” a box that opens to reveal a to-be-labelled object. In a sample of 95 children (1 to 5 years of age), 81% completed the task—32% with ≥10 trials. The task was validated (ρ = 0.4) against the gold standard Word Generation task in a group of older adults (n = 65, 60–85 years of age), though was less likely to categorize lateralization as left or right, indicative of greater measurement variability. Existing methods for active language production have been used with 2-year-old children while passive listening has been conducted with sleeping 6-month-olds. This is the first active method to be successfully employed with infants through to pre-schoolers, forming a useful tool for populations in which complex instructions are problematic.
A Clustering Strategy for the Key Segmentation of Musical Audio

Key changes are common in Western classical music. The precise segmentation of a music piece at instances where key changes occur allows for further analysis, like self-similarity analysis, chord recognition, and several other techniques that mainly pertain to the characterization of music content. This article examines the automatic segmentation of audio data into parts composed in different keys, using clustering on chroma-related spaces. To this end, the k-means algorithm is used and a methodology is proposed so that useful information about key changes can be derived, regardless of the number of clusters or key changes. The proposed methodology is evaluated by experimenting on the segmentation of recordings of existing compositions from the Classic-Romantic repertoire. Additional analysis is performed using artificial data sets. Specifically, the construction of artificial pieces is proposed as a means to investigate the potential of the strategy under discussion in predefined key-change scenarios that encompass different musical characteristics. For the existing compositions, we compare the results of our proposed methodology with others from the music information retrieval literature. Finally, although the proposed methodology is only capable of locating key changes and not the key identities themselves, we discuss results regarding the labeling of a composition's key in the located segments.
Life at the beach: comparative phylogeography of a sandhopper and its nematode parasite reveals extreme lack of parasite mtDNA variation

Molecular genetics has proven to be an essential tool for studying the ecology, evolution and epidemiology of parasitic nematodes. However, research effort across nematode taxa has not been equal and biased towards nematodes parasitic in vertebrates. We characterize the evolutionary genetics of the mermithid nematode Thaumamermis zealandica Poinar, 2002 and its host, the sandhopper Bellorchestia quoyana (Milne-Edwards, 1840) (Talitridae: Amphipoda), across sandy beaches of New Zealand’s South Island. We test the hypothesis that parasite population genetic structure mirrors that of its host. Sandhoppers and their parasites were sampled at 13 locations along the island’s southeastern coast. Sequencing of the mitochondrial gene cytochrome c oxidase subunit 1 (CO1) from B. quoyana reveals a regional pattern of population structure that suggests a northward pattern of dispersal. Surprisingly, no population structure was observed for T. zealandica. In fact, sequencing of three commonly used markers revealed no intraspecific parasite variation. This result suggests that mermithid mtDNA may evolve at an extraordinarily slow pace, perhaps as a result of extensive and frequent changes in gene order and mitochondrial genome length. Furthermore, a mermithid phylogeny based on sequences of the 18S and 28S ribosomal RNA genes suggests that a systematic revision of the family is necessary.
Studies on the behavior of extractives in mechanical pulp suspensions

The behavior of extractives of thermomechanical pulp (TMP) upon dilution and agitation, thickening by filtration, washing and water system closure was investigated in the laboratory. Lipophilic extractives, such as fatty and resin acids, triglycerides and steryl esters, as well as the more hydrophilic lignans were studied. By agitation of 1 % pulp suspensions at 60°C most of the lignans and a major part of the lipophilics were dissolved or dispersed. At pH 5 different lipophilic extractives were dissolved/dispersed without any apparent selectivity. However, at pH 8 fatty and resin acids were dissolved/dispersed to a greater extent than the neutral lipophilics. Thickening by filtration of the pulp suspension resulted in considerable retention of lipophilic extractives in the pulp mat. Again, no selectivity between the different extractive~ was found at pH 5, but at pH 8 fatty and resin acids were less retained than the neutral lipophilics. Washing by repeated dilution, agitation and filtration effectively removed fatty and resin acids at pH 8. At pH 5-6 neither acids nor neutrals were effectively removed. Lignans were easily washed out even at acidic conditions. Water system closure was simulated by successive washings of the TMP with recycled filtrates. The concentrations of the lipophilics in the filtrates initially increased linearly with the concentration of total organic substances, but clearly leveled off at higher concentrations. However, there was little change in the composition of the extractives. At pH 8 more organic material was dissolved and dispersed than at pH 5. Much of this increase was due to the increase of lipophilic extractives. The concentration of lignans increased linearly with increasing concentrations of total dissolved and dispersed organic substances at both pH levels.
Understanding the Effect of Particle Size and Processing on Almond Lipid Bioaccessibility through Microstructural Analysis: From Mastication to Faecal Collection

We have previously reported on the low lipid bioaccessibility from almond seeds during digestion in the upper gastrointestinal tract (GIT). In the present study, we quantified the lipid released during artificial mastication from four almond meals: natural raw almonds (NA), roasted almonds (RA), roasted diced almonds (DA) and almond butter from roasted almonds (AB). Lipid release after mastication (8.9% from NA, 11.8% from RA, 12.4% from DA and 6.2% from AB) was used to validate our theoretical mathematical model of lipid bioaccessibility. The total lipid potentially available for digestion in AB was 94.0%, which included the freely available lipid resulting from the initial sample processing and the further small amount of lipid released from the intact almond particles during mastication. Particle size distributions measured after mastication in NA, RA and DA showed most of the particles had a size of 1000 µm and above, whereas AB bolus mainly contained small particles (<850 µm). Microstructural analysis of faecal samples from volunteers consuming NA, RA, DA and AB confirmed that some lipid in NA, RA and DA remained encapsulated within the plant tissue throughout digestion, whereas almost complete digestion was observed in the AB sample. We conclude that the structure and particle size of the almond meals are the main factors in regulating lipid bioaccessibility in the gut.
A Study on Fracture Mechanism of Plain Woven Carbon Fabric Composite by Acoustic Emission Method (Estimation of Debonding of Fiber/Matrix and Transverse/Longitudinal Fibers).

Acoustic emission (AE) characteristics of smoothed and notched specimens were investigated for a plain woven carbon fabric composite. The failure behavior of the smoothed specimen under tensile loading was estimated by the failure modes, AE parameters, and the load -elongation curve of the notched specimen. The results obtained are as follows: (1) The AE cumulative event count and the total AE energy of the smoothed specimen were larger than those of the notched specimen due to the difference in load level. (2) The AE amplitude distribution showed that the debonding of fiber/matrix and transverse/ longitudinal fibers was the dominant failure mode before final fracture and generated much more AE than the fiber breakage. The AE activity of the smoothed specimen was larger than that of the notched specimen. (3) The load at the broken point of log-log plot for the total AE energy and stress intensity factor corresponded to the initiation of fiber/matrix debonding. It also agreed with the occurrence of AE. (4) The load-elongation curves of the smoothed and notched specimens could be divided into three parts. It was found that the initiation of the above debonding in the smoothed specimen can be estimated by the ratio of the load at the broken point to the maximum load of the notched specimen.
Swept-source OCT angiography of macular telangiectasia type 2.

BACKGROUND AND OBJECTIVE To evaluate the central macular microvascular network in patients with macular telangiectasia type 2 (MacTel2) using optical coherence tomography (OCT)-based microangiography (OMAG). PATIENTS AND METHODS Prospective, observational study of patients with MacTel2 evaluated using a swept-source OCT (SS-OCT) prototype. OMAG was performed using a 3 mm × 3 mm central foveal raster scan. The algorithm segmented the retina into three layers. Microvascular distribution was depicted as en face images, and qualitative information was compared to fluorescein angiography (FA) images. RESULTS OMAG detected abnormal microvasculature in all MacTel2 eyes, predominantly in the middle retinal layers with neovascularization in the outer retina. These vessels correlated well with the FA alterations. The abnormal temporal, juxtafoveal microvasculature in MacTel2 became apparent as the disease progressed and in later stages tended to extend circumferentially, with anastomotic vessels temporally. CONCLUSION OMAG provided detailed, depth- resolved information about the perifoveal macular microvasculature in MacTel2. In most cases, images were better using OMAG than FA. The OMAG images demonstrated that most of the leakage seen on FA appeared to arise from the abnormal perifoveal microvasculature in the middle retinal layer.
U.S. Men’s Perceptions and Experiences of Emergency Contraceptives

Research suggests that men should be included in reproductive health decision making to help enhance positive health outcomes for their partners. Men affect the use of contraception and what method is used. Men’s decisions may be affected by different factors such as gender, education, and the nature of their sexual relationship. A qualitative study was conducted to explore males’ experiences and perceptions about emergency contraception (EC), and the meanings males assign to EC. Semistructured in-depth focus groups were held with 15 men who engage in heterosexual activity recruited from a university setting in the United States. Participants expressed egalitarian views of the contraception decision-making processes, a sense of responsibility regarding reproductive decision making, and that society has a negative stigma toward those who use EC. However, there was a lack of knowledge regarding the copper intrauterine device, which was not viewed as a method of EC. Exploring the role and needs of men in reproductive health care discussions and research is an important and growing area. Recommendations are provided for health care practitioners, policy, and future research around men and EC.
Regulation of microtubule-associated motors drives intermediate filament network polarization

Intermediate filaments (IFs) are key players in the control of cell morphology and structure as well as in active processes such as cell polarization, migration, and mechanoresponses. However, the regulatory mechanisms controlling IF dynamics and organization in motile cells are still poorly understood. In this study, we investigate the mechanisms leading to the polarized rearrangement of the IF network along the polarity axis. Using photobleaching and photoconversion experiments in glial cells expressing vimentin, glial fibrillary acidic protein, and nestin, we show that the distribution of cytoplasmic IFs results from a continuous turnover based on the cooperation of an actin-dependent retrograde flow and anterograde and retrograde microtubule-dependent transports. During wound-induced astrocyte polarization, IF transport becomes directionally biased from the cell center toward the cell front. Such asymmetry in the transport is mainly caused by a Cdc42- and atypical PKC–dependent inhibition of dynein-dependent retrograde transport. Our results show how polarity signaling can affect the dynamic turnover of the IF network to promote the polarization of the network itself.
The Web as a Knowledge-Base for Answering Complex Questions

Answering complex questions is a time-consuming activity for humans that requires reasoning and integration of information. Recent work on reading comprehension made headway in answering simple questions, but tackling complex questions is still an ongoing research challenge. Conversely, semantic parsers have been successful at handling compositionality, but only when the information resides in a target knowledge-base. In this paper, we present a novel framework for answering broad and complex questions, assuming answering simple questions is possible using a search engine and a reading comprehension model. We propose to decompose complex questions into a sequence of simple questions, and compute the final answer from the sequence of answers. To illustrate the viability of our approach, we create a new dataset of complex questions, ComplexWebQuestions, and present a model that decomposes questions and interacts with the web to compute an answer. We empirically demonstrate that question decomposition improves performance from 20.8 precision@1 to 27.5 precision@1 on this new dataset.
Calcium Chloride and Calcium Gluconate in Neonatal Parenteral Nutrition Solutions without Cysteine: Compatibility Studies Using Laser Light Obscuration Methodology

There are no compatibility studies for neonatal parenteral nutrition solutions without cysteine containing calcium chloride or calcium gluconate using light obscuration as recommended by the United States Pharmacopeia (USP). The purpose of this study was to do compatibility testing for solutions containing calcium chloride and calcium gluconate without cysteine. Solutions of TrophAmine and Premasol (2.5% amino acids), containing calcium chloride or calcium gluconate were compounded without cysteine. Solutions were analyzed for particle counts using light obscuration. Maximum concentrations tested were 15 mmol/L of calcium and 12.5 mmol/L of phosphate. If the average particle count of three replicates exceeded USP guidelines, the solution was determined to be incompatible. This study found that 12.5 and 10 mmol/L of calcium and phosphate, respectively, are compatible in neonatal parenteral nutrition solutions compounded with 2.5% amino acids of either TrophAmine or Premasol. There did not appear to be significant differences in compatibility for solutions containing TrophAmine or Premasol when solutions were compounded with either CaCl2 or CaGlu-Pl. This study presents data in order to evaluate options for adding calcium and phosphate to neonatal parenteral nutrition solutions during shortages of calcium and cysteine.
Differential Effects of Retinoic Acid Concentrations in Regulating Blood–Brain Barrier Properties

Abstract The blood-brain barrier (BBB) is a multifaceted property of the brain vasculature that protects the brain and maintains homeostasis by tightly regulating the flux of ions, molecules, and cells across the vasculature. Blood vessels in the brain are formed by endothelial cells that acquire barrier properties, such as tight and adherens junctions, soon after the brain vasculature is formed. Endothelial WNT signaling is crucial to induce these BBB properties by regulating their expression and stabilization. Recent studies have implicated retinoic acid (RA) signaling in BBB development and shown that pharmacological concentrations of RA (≥5 µm) can induce BBB properties in cultured brain endothelial cells. However, a recent study demonstrated that RA inhibits endothelial WNT signaling during brain development, suggesting that RA does not promote BBB properties. We therefore investigated whether RA plays a physiological role in BBB development. We found that BBB function and junctional protein expression was unaffected in mouse mutants that have a reduced capacity to synthesize RA (Rdh10 mutants). Furthermore, embryos exposed to a RA-enriched diet did not enhance BBB protein expression. Together, our data indicate that RA is not capable of inducing, nor is it required for, BBB protein expression in vivo. Like other studies, we found that pharmacological concentrations of RA induce BBB genes in cultured murine brain endothelial cells, and this may involve activation of the LXR/RXR signaling pathway. Our data do not support a role for RA in BBB development, but confirm reports that pharmacological RA is a robust tool to induce BBB properties in culture.
The role of attachment in Facebook usage: a study of Canadian college students

ABSTRACT Considering the increasingly ubiquitous and frequent use of Facebook among college students, this study sought to explicate and unravel the salient determinants of Facebook use. Specifically, the main goal was to ascertain the factors influencing Collège d'enseignement général et professionnel (CEGEP) students’ Facebook use, for which a structural equation model was proposed to examine the relationships between constructs affecting this process. Using a recently proposed extended technology acceptance model, Dhammic Technology Acceptance Model (DTAM) for Facebook use, proposed by Teo and Jarupunphol [2015. Dhammic technology acceptance model (DTAM): Extending the TAM using a condition of attachment in Buddhism. Journal of Educational Computing Research, 52(1), 136–151. doi:10.1177/0735633114568859], we present results of the study using 233 completed survey data from a sample of CEGEP students in Montreal, Quebec. The DTAM was originally tested using a sample of Thai university students; this leads to a natural question as to whether this extended Technology Acceptance Model (TAM) model holds in a Western sample. The findings from the present study support the validity of the DTAM for explicating Facebook use, and add empirical evidence to the DTAM, according to which the condition of attachment exerts influence on Facebook use. The paper concludes with a discussion of the implications, limitations, and future extensions of the study.
A Benchmark Study on Sentiment Analysis for Software Engineering Research

A recent research trend has emerged to identify developers' emotions, by applying sentiment analysis to the content of communication traces left in collaborative development environments. Trying to overcome the limitations posed by using off-the-shelf sentiment analysis tools, researchers recently started to develop their own tools for the software engineering domain. In this paper, we report a benchmark study to assess the performance and reliability of three sentiment analysis tools specifically customized for software engineering. Furthermore, we offer a reflection on the open challenges, as they emerge from a qualitative analysis of misclassified texts.
On Older Listeners' Ability to Perceive Dynamic Pitch.

PURPOSE Natural speech comes with variation in pitch, which serves as an important cue for speech recognition. The present study investigated older listeners' dynamic pitch perception with a focus on interindividual variability. In particular, we asked whether some of the older listeners' inability to perceive dynamic pitch stems from the higher susceptibility to the interference from formant changes. METHOD A total of 22 older listeners and 21 younger controls with at least near-typical hearing were tested on dynamic pitch identification and discrimination tasks using synthetic monophthong and diphthong vowels. RESULTS The older listeners' ability to detect changes in pitch varied substantially, even when musical and linguistic experiences were controlled. The influence of formant patterns on dynamic pitch perception was evident in both groups of listeners. Overall, strong pitch contours (i.e., more dynamic) were perceived better than weak pitch contours (i.e., more monotonic), particularly with rising pitch patterns. CONCLUSIONS The findings are in accordance with the literature demonstrating some older individuals' difficulty perceiving dynamic pitch cues in speech. Moreover, they suggest that this problem may be prominent when the dynamic pitch is carried by natural speech and when the pitch contour is not strong.
Learning Options From Demonstrations: A Pac-Man Case Study

Reinforcement learning (RL) is a machine learning paradigm behind many successes in games, robotics, and control applications. RL agents improve through trial-and-error, therefore undergoing a learning phase during which they perform suboptimally. Research effort has been put into optimizing behavior during this period, to reduce its duration and to maximize after-learning performance. We introduce a novel algorithm that extracts useful information from expert demonstrations (traces of interactions with the target environment) and uses it to improve performance. The algorithm detects unexpected decisions made by the expert and infers what goal the expert was pursuing. Goals are then used to bias decisions while learning. Our experiments in the video game Pac-Man provide statistically significant evidence that our method can improve final performance compared to a state-of-the-art approach.
Analysis of nonlinear dynamic stability for carbon nanotube-reinforced composite plates resting on elastic foundations

ABSTRACT This article studies nonlinear dynamic stability of carbon nanotube-reinforced composite (CNTRC) plates resting on an elastic foundation. The single-walled carbon nanotubes (SWCNTs) are aligned and distributed in the form of uniformly distributed (UD) and functionally graded (FG) reinforcements. The governing equations are established based on classic plate theory, which is converted to a Mathieu-type equation by using a two-step perturbation technique, and then solved by adopting an incremental harmonic balanced (IHB) method. In numerical results, the effects of nonlinear geometric factor, distribution and fraction volume of CNTs, and foundation stiffness on principle dynamic unstable regions are discussed.