Miracle-dz/UniFAR-FTUs huggingface dataset:
Protective Role of Beta Interferon in Host Defense against Influenza A Virus

ABSTRACT Type I interferon (IFN), which includes the IFN-α and -β subtypes, plays an essential role in host defense against influenza A virus. However, the relative contribution of IFN-β remains unresolved. In mice, type I IFN is effective against influenza viruses only if the IFN-induced resistance factor Mx1 is present, though most inbred mouse strains, including the recently developed IFN-β-deficient mice, bear only defective Mx1 alleles. We therefore generated IFN-β-deficient mice carrying functional Mx1 alleles (designated Mx-BKO) and compared them to either wild-type mice bearing functional copies of both IFN-β and Mx1 (designated Mx-wt) or mice carrying functional Mx1 alleles but lacking functional type I IFN receptors (designated Mx-IFNAR). Influenza A virus strain SC35M (H7N7) grew to high titers and readily formed plaques in monolayers of Mx-BKO and Mx-IFNAR embryo fibroblasts which showed no spontaneous expression of Mx1. In contrast, Mx-wt embryo fibroblasts were found to constitutively express Mx1, most likely explaining why SC35M did not grow to high titers and formed no visible plaques in such cells. In vivo challenge experiments in which SC35M was applied via the intranasal route showed that the 50% lethal dose was about 20-fold lower in Mx-BKO mice than in Mx-wt mice and that virus titers in the lungs were increased in Mx-BKO mice. The resistance of Mx-BKO mice to influenza A virus strain PR/8/34 (H1N1) was also substantially reduced, demonstrating that IFN-β plays an important role in the defense against influenza A virus that cannot be compensated for by IFN-α.
Severity of pancreatitis-associated intestinal mucosal barrier injury is reduced following treatment with the NADPH oxidase inhibitor apocynin

Recent studies demonstrated that apocynin, a nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) inhibitor, significantly decreased acute pancreatitis-associated inflammatory and oxidative stress parameters. In addition, apocynin was able to reduce ischemic reperfusion injury-associated damage; however, the exact effects of apocynin on acute pancreatitis-associated intestinal mucosal injury have yet to be fully clarified. The present study aimed to investigate the protective effects of apocynin on intestinal mucosal injury in a rat model of severe acute pancreatitis (SAP). A total of 60 male Sprague Dawley rats were randomly divided into four groups (n=15/group): Sham operation group (SO), SAP group, apocynin treatment (APO) group and drug control (APO-CON) group. SAP was induced by retrograde injection of 5% sodium taurocholate into the biliopancreatic duct. Apocynin was administered 30 min prior to SAP induction in the APO group. All rats were sacrificed 12 h after SAP induction. Intestinal integrity was assessed by measuring diamine oxidase (DAO) levels. Morphological alterations to intestinal tissue were determined under light and transmission electron microscopy. NOX2, p38 mitogen-activated protein kinases (MAPK) and nuclear factor (NF)-κB expression levels were detected in the intestine by immunohistochemical staining. Oxidative stress was detected by measuring intestinal malondialdehyde (MDA) and superoxide dismutase content. In addition, blood inflammatory cytokines, and amylase (AMY) and lipase (LIP) levels were evaluated. The results demonstrated that apocynin attenuated the following: i) Serum AMY, LIP and DAO levels; ii) pancreatic and intestinal pathological injury; iii) intestinal MDA content; iv) intestinal ultrastructural alterations; v) serum interleukin (IL)-1β, IL-6 and tumor necrosis factor (TNF)-α levels; and vi) NOX2, p38 MAPK and NF-κB expression in intestinal tissues. These results suggested that apocynin may attenuate intestinal barrier dysfunction in sodium taurocholate-induced SAP, presumably via its role in the prevention of reactive oxygen species generation and inhibition of p38 MAPK and NF-κB pathway activation. These findings provide novel insight suggesting that pharmacological inhibition of NOX by apocynin may be considered a novel therapeutic method for the treatment of intestinal injury in SAP.
Exploring Attribute Selection in Hierarchical Classification

In the domain of many classification problems, classes have relations of dependency that are represented in hierarchical structures. These problems are known as hierarchical classification problems. Methods based on different approaches, considering hierarchical relations in different ways, have been proposed to solve them, in the attempt to achieve better predictive performance. In this work, we explore attribute selection techniques in conjunction with hierarchical classifiers from different categories, with the goal of improving their respective performances. Computational experiments, made with 18 hierarchical datasets, have indicated that the adopted classifiers attain better predictive accuracy when the most relevant attributes are considered in their construction.
Estimating the Quality of Data in Relational Databases

With more and more electronic information sources becoming widely available, the issue of the quality of these, often-competing, sources has become germane. We propose a standard for rating information sources with respect to their quality. An important consideration is that the quality of information sources often varies considerably when specific areas within these sources are considered. This implies that the assignment of a single rating of quality to an information source is usually unsatisfactory. Of course, to the user of an information source the overall quality of the source may not be as important as the quality of the specific information that this user is extracting from the source. Therefore, methods must be developed that will derive reliable estimates of the quality of the information provided to users, from the quality specifications that have been assigned to the sources. Our work here bears on all these concerns. We describe an approach that uses dual quality measures that gauge the distance of the information in a database from the truth. We then propose to combine manual verification with statistical methods to arrive at useful estimates of the quality of databases. We consider the variance in quality by isolating areas of databases that are homogeneous with respect to quality, and then estimating the quality of each separate area. These composite estimates may be regarded as quality specifications that will be affixed to each database. Finally, we show how to derive quality estimates for individual queries from such quality specifications. This work was supported in part by DARPA grants N0014-92-J-4038 and N0060-96-D-3202.
Effect of an Emotion Regulation Training Program on Mental Well-Being

ABSTRACT This study aimed to develop and validate a brief emotion regulation training program that improved mental well-being. The program was preventative in nature, designed to build resilience while fostering more satisfying personal and professional relationships in a community sample. It was developed and piloted with 10 graduate students during Study 1; for Study 2, a community sample of 75 adults were randomly allocated to either a treatment (n = 38) or control (n = 37) group. In the pilot program, the social validity of the program was confirmed, while study 2 demonstrated significant changes in positive coping techniques (i.e., reappraisal) at one-year follow-up in the treatment group when compared with the control. These findings may have broad implications in the health sector due to the brevity, scalability, and cost-effectiveness of this newly designed intervention.
Multiport converters for hybrid power sources

Multiport converters, a promising concept for hybrid power sources, have attracted increasing research interest recently. The use of a single power processing stage to interface multiple power inputs integrates power conversion for a hybrid power source. This structure removes redundant power stages that would exist in the conventional approach that uses multiple converters. The multiport structure is promising from the viewpoints of centralized control and compact packaging. The proposed basic bidirectional switching cells show several possibilities to construct a multiport converter. Several three-port topologies are discussed. Furthermore, based on the interleaving technology, topologies for higher power applications are also provided.
Spatiotemporal Dependency of Age-Related Changes in Brain Signal Variability

Recent theoretical and empirical work has focused on the variability of network dynamics in maturation. Such variability seems to reflect the spontaneous formation and dissolution of different functional networks. We sought to extend these observations into healthy aging. Two different data sets, one EEG (total n = 48, ages 18–72) and one magnetoencephalography (n = 31, ages 20–75) were analyzed for such spatiotemporal dependency using multiscale entropy (MSE) from regional brain sources. In both data sets, the changes in MSE were timescale dependent, with higher entropy at fine scales and lower at more coarse scales with greater age. The signals were parsed further into local entropy, related to information processed within a regional source, and distributed entropy (information shared between two sources, i.e., functional connectivity). Local entropy increased for most regions, whereas the dominant change in distributed entropy was age-related reductions across hemispheres. These data further the understanding of changes in brain signal variability across the lifespan, suggesting an inverted U-shaped curve, but with an important qualifier. Unlike earlier in maturation, where the changes are more widespread, changes in adulthood show strong spatiotemporal dependence.
Meta-Analysis on Prevalence and Attribution of Human Papillomavirus Types 52 and 58 in Cervical Neoplasia Worldwide

Objective To estimate the prevalence and attribution of two non-vaccine-covered HPV types (HPV52 and HPV58) across the world. Methods Meta-analysis on studies reported in English and Chinese between 1994 and 2012. Results The pooled prevalence and attribution rates of HPV52 and HPV58 in invasive cervical cancers were significantly higher in Eastern Asia compared to other regions (HPV52 prevalence: 5.7% vs. 1.8–3.6%, P<0.001; HPV52 attribution: 3.7% vs. 0.2–2.0%; HPV58 prevalence: 9.8% vs. 1.1–2.5%, P<0.001; HPV58 attribution: 6.4% vs. 0.7–2.2%, P<0.001). Oceania has an insufficient number of studies to ascertain the prevalence of HPV52. Within Eastern Asia, the attribution of HPV58 to invasive cervical cancer was 1.8-fold higher than that of HPV52. Similarly, HPV52 and HPV58 shared a higher prevalence and attribution among cervical intraepithelial neoplasia in Eastern Asia. In contrast to the classical high-risk type, HPV16, the prevalence and attribution of HPV52 and HPV58 decreased with increasing lesion severity. Thus, HPV52 and HPV58 behave as an “intermediate-risk” type. Conclusion The attribution of HPV52 and HPV58 to cervical intraepithelial neoplasia and invasive cancer in Eastern Asia were respectively 2.5–2.8 and 3.7–4.9 folds higher than elsewhere. Changes in the attributed disease fraction can serve as a surrogate marker for cross-protection or type replacement following widespread use of HPV16/18-based vaccines. This unique epidemiology should be considered when designing HPV screening assays and vaccines for Eastern Asia.
Supporting collaborative inquiry during a biology field trip with mobile peer-to-peer tools for learning: a case study with K-12 learners

This study explores how collaborative inquiry learning can be supported with multiple scaffolding agents in a real-life field trip context. In practice, a mobile peer-to-peer messaging tool provided meta-cognitive and procedural support, while tutors and a nature guide provided more dynamic scaffolding in order to support argumentative discussions between groups of students during the co-creation of knowledge claims. The aim of the analysis was to identify and compare top- and low-performing dyads/triads in order to reveal the differences regarding their co-construction of arguments while creating knowledge claims. Although the results revealed several shortcomings in the types of argumentation, it could be established that differences between the top performers and low performers were statistically significant in terms of social modes of argumentation, the use of warrants in the mobile tool and in overall participation. In general, the use of the mobile tool likely promoted important interaction during inquiry learning, but led to superficial epistemological quality in the knowledge claim messages.
HIV Infection and Compromised Mucosal Immunity: Oral Manifestations and Systemic Inflammation

Mucosal surfaces account for the vast majority of HIV transmission. In adults, HIV transmission occurs mainly by vaginal and rectal routes but rarely via oral route. By contrast, pediatric HIV infections could be as the result of oral route by breastfeeding. As such mucosal surfaces play a crucial role in HIV acquisition, and spread of the virus depends on its ability to cross a mucosal barrier. HIV selectively infects, depletes, and/or dysregulates multiple arms of the human immune system particularly at the mucosal sites and causes substantial irreversible damage to the mucosal barriers. This leads to microbial products translocation and subsequently hyper-immune activation. Although introduction of antiretroviral therapy (ART) has led to significant reduction in morbidity and mortality of HIV-infected patients, viral replication persists. As a result, antigen presence and immune activation are linked to “inflammaging” that attributes to a pro-inflammatory environment and the accelerated aging process in HIV patients. HIV infection is also associated with the prevalence of oral mucosal infections and dysregulation of oral microbiota, both of which may compromise the oral mucosal immunity of HIV-infected individuals. In addition, impaired oral immunity in HIV infection may predispose the patients to periodontal diseases that are associated with systemic inflammation and increased risk of cardiovascular diseases. The purpose of this review is to examine existing evidence regarding the role of innate and cellular components of the oral cavity in HIV infection and how HIV infection may drive systemic hyper-immune activation in these patients. We will also discuss current knowledge on HIV oral transmission, HIV immunosenescence in relation to the oral mucosal alterations during the course of HIV infection and periodontal disease. Finally, we discuss oral manifestations associated with HIV infection and how HIV infection and ART influence the oral microbiome. Therefore, unraveling how HIV compromises the integrity of the oral mucosal tissues and innate immune components of the oral cavity and its association with induction of chronic inflammation are critical for the development of effective preventive interventions and therapeutic strategies.
Pharmacologic Approaches Against Advanced Glycation End Products (AGEs) in Diabetic Cardiovascular Disease

Context: Advanced Glycation End-Products (AGEs) are signaling proteins associated to several vascular and neurological complications in diabetic and non-diabetic patients. AGEs proved to be a marker of negative outcome in both diabetes management and surgical procedures in these patients. The reported role of AGEs prompted the development of pharmacological inhibitors of their effects, giving rise to a number of both preclinical and clinical studies. Clinical trials with anti-AGEs drugs have been gradually developed and this review aimed to summarize most relevant reports. Evidence Acquisition: Evidence acquisition process was performed using PubMed and ClinicalTrials.gov with manually checked articles. Results: Pharmacological approaches in humans include aminoguanidine, pyridoxamine, benfotiamine, angiotensin converting enzyme inhibitors, angiotensin receptor blockers, statin, ALT-711 (alagebrium) and thiazolidinediones. The most recent promising anti-AGEs agents are statins, alagebrium and thiazolidinediones. The role of AGEs in disease and new compounds interfering with their effects are currently under investigation in preclinical settings and these newer anti-AGEs drugs would undergo clinical evaluation in the next years. Compounds with anti-AGEs activity but still not available for clinical scenarios are ALT-946, OPB-9195, tenilsetam, LR-90, TM2002, sRAGE and PEDF. Conclusions: Despite most studies confirm the efficacy of these pharmacological approaches, other reports produced conflicting evidences; in almost any case, these drugs were well tolerated. At present, AGEs measurement has still not taken a precise role in clinical practice, but its relevance as a marker of disease has been widely shown; therefore, it is important for clinicians to understand the value of new cardiovascular risk factors. Findings from the current and future clinical trials may help in determining the role of AGEs and the benefits of anti-AGEs treatment in cardiovascular disease.
Diversity in Online News

This paper examines diversity in online news with special attention paid to the role of different types of media ownership (meso level) and media systems (macro level). After identifying relevant perspectives and operationalizations of diversity, and discussing the economic implications of ownership and market conditions for diversity, the study tests four hypotheses with a content analysis of 1660 stories from 48 news sites in six countries (United States, United Kingdom, France, Italy, Germany, and Switzerland). Findings show that online news attains the highest levels of diversity (measured with three different indices) in national environments with strong public service media, and that even in the internet age, public broadcasters add considerably to the diversity of political news. The much discussed category of made-for-Web outlets (including the Huffington Post and Rue89) revealed considerable variety in ownership and escape simple explanations with regard to diversity.
The National Livestock Identification System: The Importance of Traceability in E-Business

This paper aims to explore how Radio Frequency Identification (RFID) can be utilized on dairy farms to enhance total farm management. There is a growing worldwide trend for countries to implement whole-of-life traceability systems for livestock, and RFID is clearly the dominant technology being chosen to achieve this aim. In line with this global trend, and to meet the requirements of key trading partners (such as the EU), Australia has implemented the National Livestock Identification System (NLIS) to provide whole-of-life traceability for livestock- a system based on the use of RFID devices. As such, it is proposed that dairy farmers utilise RFID so as to not only comply with NLIS requirements, but to extend the use of RFID onto their farms so as to provide additional benefits for themselves through subsequent enhancements in farm management practices.
Polyomavirus BK Replication in De Novo Kidney Transplant Patients Receiving Tacrolimus or Cyclosporine: A Prospective, Randomized, Multicenter Study

Polyomavirus BK (BKV)‐associated nephropathy causes premature kidney transplant (KT) failure. BKV viruria and viremia are biomarkers of disease progression, but associated risk factors are controversial. A total of 682 KT patients receiving basiliximab, mycophenolic acid (MPA), corticosteroids were randomized 1:1 to cyclosporine (CsA) or tacrolimus (Tac). Risk factors were analyzed in 629 (92.2%) patients having at least 2 BKV measurements until month 12 posttransplant. Univariate analysis associated CsA‐MPA with lower rates of viremia than Tac‐MPA at month 6 (10.6% vs. 16.3%, p = 0.048) and 12 (4.8% vs. 12.1%, p = 0.004) and lower plasma BKV loads at month 12 (3.9 vs. 5.1 log10 copies/mL; p = 0.028). In multivariate models, CsA‐MPA remained associated with less viremia than Tac‐MPA at month 6 (OR 0.60; 95% CI 0.36–0.99) and month 12 (OR 0.33; 95% CI 0.16–0.68). Viremia at month 6 was also independently associated with higher steroid exposure until month 3 (OR 1.19 per 1 g), and with male gender (OR 2.49) and recipient age (OR 1.14 per 10 years) at month 12. The data suggest a dynamic risk factor evolution of BKV viremia consisting of higher corticosteroids until month 3, Tac‐MPA compared to CsA‐MPA at month 6 and Tac‐MPA, older age, male gender at month 12 posttransplant.
Investigation and validation of intersite fMRI studies using the same imaging hardware

To provide a between‐site comparison of functional MRI (fMRI) signal reproducibility in two laboratories equipped with identical imaging hardware and software. Many studies have looked at within‐subject reliability and more recent efforts have begun to calibrate responses across sites, magnetic field strengths, and software. By comparing identical imaging hardware and software, we provide a benchmark for future multisite comparisons.
Cochannel interference cancellation using optimized joint equalization

In this paper, single-carrier transmission impaired by cochannel interference is considered, which generally arises in a GSM/EDGE mobile radio network. Here, cochannel interference is created due to the reuse of the frequencies in nearby cells. In the case, that only a single antenna is available at the mobile receiver, the (multiple-input single-output) system is overloaded and equalization with low complexity is difficult. The optimum joint maximum-likelihood sequence estimation (JMLSE) algorithm would require a huge number of channel states to be considered in a corresponding Viterbi algorithm. The usage of a channel shortening filter in combination with a joint M-algorithm for detection was proposed in [1] in order to obtain good performance results at low complexity for single-antenna interference cancellation (SAIC) in the low-to-moderate carrier-to-interference power ratio (CIR) range, but unfortunately the M-algorithm has shown worse performance than joint delayed-decision feedback sequence estimation (JDDFSE) or joint reduced-state sequence estimation (JRSSE) for high CIRs. To solve this problem, we consider a combined scheme of JRSSE and the M-algorithm for joint detection of the desired user signal and one or more interferers, which corresponds to a special application of breadth-first sequence detection [2]. For the considered algorithm, each trellis state u is equipped with a list of M (best) paths to be stored and processed forward.
Privacy-Preserving Outsourced Media Search

This work proposes a privacy-protection framework for an important application called outsourced media search. This scenario involves a data owner, a client, and an untrusted server, where the owner outsources a search service to the server. Due to lack of trust, the privacy of the client and the owner should be protected. The framework relies on multimedia hashing and symmetric encryption. It requires involved parties to participate in a privacy-enhancing protocol. Additional processing steps are carried out by the owner and the client: (i) before outsourcing low-level media features to the server, the owner has to one-way hash them, and partially encrypt each hash-value; (ii) the client completes the similarity search by re-ranking the most similar candidates received from the server. One-way hashing and encryption add ambiguity to data and make it difficult for the server to infer contents from database items and queries, so the privacy of both the owner and the client is enforced. The proposed framework realizes trade-offs among strength of privacy enforcement, quality of search, and complexity, because the information loss can be tuned during hashing and encryption. Extensive experiments demonstrate the effectiveness and the flexibility of the framework.