Miracle-dz/UniFAR-FTUs huggingface dataset:
Matrix-Applied Characterized Autologous Cultured Chondrocytes Versus Microfracture: Five-Year Follow-up of a Prospective Randomized Trial

Background: Matrix-based cell therapy improves surgical handling, increases patient comfort, and allows for expanded indications with better reliability within the knee joint. Five-year efficacy and safety of autologous cultured chondrocytes on porcine collagen membrane (MACI) versus microfracture for treating cartilage defects have not yet been reported from any randomized controlled clinical trial. Purpose: To examine the clinical efficacy and safety results at 5 years after treatment with MACI and compare these with the efficacy and safety of microfracture treatment for symptomatic cartilage defects of the knee. Study Design: Randomized controlled trial; Level of evidence, 1. Methods: This article describes the 5-year follow-up of the SUMMIT (Superiority of MACI Implant Versus Microfracture Treatment) clinical trial conducted at 14 study sites in Europe. All 144 patients who participated in SUMMIT were eligible to enroll; analyses of the 5-year data were performed with data from patients who signed informed consent and continued in the Extension study. Results: Of the 144 patients randomized in the SUMMIT trial, 128 signed informed consent and continued observation in the Extension study: 65 MACI (90.3%) and 63 microfracture (87.5%). The improvements in Knee injury and Osteoarthritis Outcome Score (KOOS) Pain and Function domains previously described were maintained over the 5-year follow-up. Five years after treatment, the improvement in MACI over microfracture in the co-primary endpoint of KOOS pain and function was maintained and was clinically and statistically significant (P = .022). Improvements in activities of daily living remained statistically significantly better (P = .007) in MACI patients, with quality of life and other symptoms remaining numerically higher in MACI patients but losing statistical significance relative to the results of the SUMMIT 2-year analysis. Magnetic resonance imaging (MRI) evaluation of structural repair was performed in 120 patients at year 5. As in the 2-year SUMMIT (MACI00206) results, the MRI evaluation showed improvement in defect filling for both treatments; however, no statistically significant differences were noted between treatment groups. Conclusion: Symptomatic cartilage knee defects 3 cm2 or larger treated with MACI were clinically and statistically significantly improved at 5 years compared with microfracture treatment. No remarkable adverse events or safety issues were noted in this heterogeneous patient population.
Discriminability and Perceptual Saliency of Temporal and Spectral Cues for Final Fricative Consonant Voicing in Simulated Cochlear-Implant and Bimodal Hearing

Multiple redundant acoustic cues can contribute to the perception of a single phonemic contrast. This study investigated the effect of spectral degradation on the discriminability and perceptual saliency of acoustic cues for identification of word-final fricative voicing in “loss” versus “laws”, and possible changes that occurred when low-frequency acoustic cues were restored. Three acoustic cues that contribute to the word-final /s/-/z/ contrast (first formant frequency [F1] offset, vowel–consonant duration ratio, and consonant voicing duration) were systematically varied in synthesized words. A discrimination task measured listeners’ ability to discriminate differences among stimuli within a single cue dimension. A categorization task examined the extent to which listeners make use of a given cue to label a syllable as “loss” versus “laws” when multiple cues are available. Normal-hearing listeners were presented with stimuli that were either unprocessed, processed with an eight-channel noise-band vocoder to approximate spectral degradation in cochlear implants, or low-pass filtered. Listeners were tested in four listening conditions: unprocessed, vocoder, low-pass, and a combined vocoder + low-pass condition that simulated bimodal hearing. Results showed a negative impact of spectral degradation on F1 cue discrimination and a trading relation between spectral and temporal cues in which listeners relied more heavily on the temporal cues for “loss-laws” identification when spectral cues were degraded. Furthermore, the addition of low-frequency fine-structure cues in simulated bimodal hearing increased the perceptual saliency of the F1 cue for “loss-laws” identification compared with vocoded speech. Findings suggest an interplay between the quality of sensory input and cue importance.
Neglected Patterns of Variation in Phenotypic Plasticity: Age- and Sex-Specific Antipredator Plasticity in a Cichlid Fish

The ability of organisms to plastically respond to changing environments is well studied. However, variation in phenotypic plasticity during ontogeny is less well understood despite its relevance of being an important source of phenotypic variation in nature. Here, we comprehensively study ontogenetic variation in morphological antipredator plasticity across multiple traits in Pelvicachromis taeniatus, a western African cichlid fish with sexually dimorphic ornamentation. In a split-clutch design, fish were raised under different levels of perceived predation risk (conspecific alarm cues or distilled water). Morphological plasticity varied substantially across ontogeny: it was first observable at an early juvenile stage where alarm cue–exposed fish grew faster. Subsequently, significant plasticity was absent until the onset of sexual maturity. Here, alarm cue–exposed males were larger than control males, which led to deeper bodies, longer dorsal spines, larger caudal peduncles, and increased eye diameters. Sexual ornamentation emerged delayed in alarm cue–exposed males. In later adulthood, the plastic responses receded. Despite small effect sizes, these responses represent putative adaptive plasticity, as they are likely to reduce predation risk. In females, we did not observe any plasticity. In accordance with theory, these results suggest fine-tuned expression of plasticity that potentially increases defenses during vulnerable developmental stages and reproductive output.
Smartphone addiction proneness in relation to sleep and morningness–eveningness in German adolescents

Background Mobile phones are an important part of adolescents’ life. In this study, the relationships among smartphone addiction, age, gender, and chronotype of German adolescents were examined. Materials and methods Two studies focused on two different measures of smartphone addiction. The Smartphone Addiction Proneness Scale (SAPS) was applied to 342 younger adolescents (13.39 ± 1.77; 176 boys, 165 girls, and 1 not indicated) in Study 1 and the Smartphone Addiction Scale was applied to 208 older adolescents (17.07 ± 4.28; 146 girls and 62 boys) in Study 2, both samples in southwest Germany. In addition, a demographic questionnaire and the Composite Scale of Morningness (CSM) and sleep measures were implemented. Results The most remarkable result of this study was that morningness–eveningness (as measured by CSM scores) is an important predictor for smartphone addiction; even stronger than sleep duration. Evening oriented adolescents scored higher on both smartphone addiction scales. In addition, gender is an important predictor for smartphone addiction and girls are more prone to become addicted. In addition, while sleep duration on weekdays negatively predicted SAPS, age, sleep duration on weekends, and midpoint of sleep on weekdays and weekends did not predicted smartphone addiction in both scales. The analysis of covariance revealed statistically significant effects of the covariates gender and age in both studies, as well as the main effect of chronotype. According to the t-test results, girls had higher scores than boys in smartphone addiction. Conclusion Evening types and girls are more prone to become smartphone addicted.
Open access – Review THIS ARTICLE IS PART OF A SPECIAL ISSUE ENTITLED ‘PHRAGMITES AUSTRALIS IN NORTH AMERICA AND EUROPE’ Hybridization of common reed in North America? The answer is blowing in the wind

Background and aims We review evidence for hybridization of Phragmites australis in North America and the implications for the persistence of native P. australis ssp. americanus populations in North America. We also highlight the need for an updated classification system, which takes P. australis intraspecific variation and hybridization into account. Methodology We reviewed available published, in press and in preparation literature to assess the likelihood of hybridization and interbreeding in genotypes of P. australis present in North America. Principal results Experimental results demonstrate that hybridization among introduced and native haplotypes is possible within the genus Phragmites, yet evidence that hybridization has occurred naturally is only starting to emerge. The lag in identifying hybridization in Phragmites in North America may be related to under-sampling in some parts of North America and to a lack of molecular tools that provide the capability to recognize hybrids. Conclusions Our understanding of the gene flow within and between species in the genus Phragmites is moving at a fast pace, especially on the east and Gulf coasts of North America. More attention should also be focused on the Great Lakes region, the southwestern and the west coast of the USA, where sympatry has created opportunities for hybridization. Where hybridizations have been detected, there are currently no published data on how hybridization affects plant vigour, morphology, invasiveness or conservation of the genetic integrity of the North American native subspecies. We conclude that the detection of more hybridization is highly likely and that there is a need to develop new markers for the different Phragmites species and lineages to fill current knowledge gaps. Finally, we suggest that the classification system for P. australis should be updated and published to help clarify the nomenclature. * Corresponding author’s e-mail address: lameyerson@gmail.com Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. AoB PLANTS http://aobplants.oxfordjournals.org/ AoB PLANTS 2012: pls022; doi:10.1093/aobpla/pls022, available online at www.aobplants.oxfordjournals.org & The Authors 2012 1
Maximum Distance Minimum Error (MDME): A non-parametric approach to feature selection for image-based high content screening data

Feature selection is a necessary preprocessing step in data analytics. Most distribution-based feature selection algorithms are parametric approaches that assume a normal distribution for the data. Often times, however, real world data do not follow a normal distribution, instead following a lognormal distribution. This is especially true in biology where latent factors often dictate distribution patterns. Parametric-based approaches are not well suited for this type of distribution. We propose the Maximum Distance Minimum Error (MDME) method, a non-parametric approach capable of handling both normal and log-normal data sets. The MDME method is based on the Kolmogorov-Smirnov test, which is well known for its ability to accurately test the dependency between two distributions without normal distribution assumptions. We test our MDME method on multiple datasets and demonstrate that our approach performs comparable to and often times better than the traditional parametric-based approaches.
Antigenic and genetic characteristics of zoonotic influenza viruses and development of candidate vaccine viruses for pandemic preparedness.

Since their emergence in 1997, highly pathogenic avian influenza (HPAI) A(H5) viruses of the A/goose/Guangdong/1/96 haemagglutinin (HA) lineage have become enzootic in some countries, have infected wild birds and continue to cause outbreaks in poultry and sporadic human infections. These viruses have diversified genetically and antigenically, leading to the need for multiple CVVs. Notably, H5 viruses have been detected with the N1 gene segment replaced by N2, N3, N5, N6, N8 or N9 gene segments. This summary provides updates on the characterization of A/goose/Guangdong/1/96-lineage A(H5) viruses and the current status of the development of influenza A(H5) CVVs.
The distribution of Mn2+ in rabbit eyes after topical administration for manganese-enhanced MRI.

PURPOSE To analyze the distribution of Mn(2+) in rabbit eyes after topical administration of Mncl2 for manganese-enhanced MRI. METHODS Forty-eight Chinese white rabbits were divided into three groups. In group 1 (n = 4), the baseline concentration of Mn(2+) in aqueous, vitreous and serum samples were analyzed. In group 2 and 3, the rabbits received one topical instillation (20 μL) of Mncl2 (1 mol • L(-1)). In group 2 (n = 40), aqueous, vitreous and serum samples were collected and analyzed at predetermined time points (0.5, 1, 2, 4, 6, 12, 24, 48, 72 and 168 hours postdose). Assays were performed using inductively coupled plasma-mass spectrometer (ICP-MS). In group 3 (n = 4), after topical administration of Mncl2, dynamic manganese-enhanced MRI (MEMRI) was performed at predetermined time points. The signal-to-noise ratio (SNR) was calculated to evaluate the enhancements of eyes. RESULTS After topical administration, the maximum concentrations of Mn(2+) in the aqueous and vitreous samples were 11.1641 ± 0.7202 (2 hours) and 1.5622 ± 0.1567 (12 hours). In group 3, the maximum enhancement of aqueous humor (SNR = 108.81 ± 10.65) appeared at 2 hours postdose, whereas, no significant changes were detected in vitreous. CONCLUSION Mn(2+) could distribute into aqueous humor rapidly after topical administration of Mncl2, whereas, the concentration of Mn(2+) in vitreous body fluctuated in a narrow range over the course. The uptake of Mn(2+) in retina may involve several different pathways.
Psychological Determinants of Consumer Acceptance of Personalised Nutrition in 9 European Countries

Objective To develop a model of the psychological factors which predict people’s intention to adopt personalised nutrition. Potential determinants of adoption included perceived risk and benefit, perceived self-efficacy, internal locus of control and health commitment. Methods A questionnaire, developed from exploratory study data and the existing theoretical literature, and including validated psychological scales was administered to N = 9381 participants from 9 European countries (Germany, Greece, Ireland, Poland, Portugal, Spain, the Netherlands, the UK, and Norway). Results Structural equation modelling indicated that the greater participants’ perceived benefits to be associated with personalised nutrition, the more positive their attitudes were towards personalised nutrition, and the greater their intention to adopt it. Higher levels of nutrition self-efficacy were related to more positive attitudes towards, and a greater expressed intention to adopt, personalised nutrition. Other constructs positively impacting attitudes towards personalised nutrition included more positive perceptions of the efficacy of regulatory control to protect consumers (e.g. in relation to personal data protection), higher self-reported internal health locus of control, and health commitment. Although higher perceived risk had a negative relationship with attitude and an inverse relationship with perceived benefit, its effects on attitude and intention to adopt personalised nutrition was less influential than perceived benefit. The model was stable across the different European countries, suggesting that psychological factors determining adoption of personalised nutrition have generic applicability across different European countries. Conclusion The results suggest that transparent provision of information about potential benefits, and protection of consumers’ personal data is important for adoption, delivery of public health benefits, and commercialisation of personalised nutrition.
Semi-adiabatic Curing Test with Heat Loss Compensation for Evaluation of Adiabatic Temperature Rise of Concrete

Early thermal cracking has been a prevalent problem in many concrete structures. To mitigate such cracking problem, the adiabatic temperature rise of the curing concrete needs to be limited. In practice, curing tests in different forms of temperature rise evaluation test (TRET) are often employed to determine the temperature rise of concrete. However, due to heat loss to the surroundings, the results from TRET do not truly reflect the temperature rise of concrete under adiabatic condition. To address this issue, a semi-adiabatic curing test method with heat loss compensation to simulate the adiabatic condition was developed as presented in this paper. Using the test method, the adiabatic temperature rise and heat generation of ordinary Portland cement (OPC) concrete, pulverised fuel ash (PFA) concrete and condensed silica fume (CSF) concrete were measured. Based on the test results, design charts for estimating the adiabatic temperature rise of OPC, PFA and CSF concretes were devised.
AN IN VITRO EVALUATION OF HUMAN SALIVA PENETRATION IN OBTURATED ROOT CANALS WITH DIFFERENT PAIRS OF ROOT CANAL FILLING MATERIALS

Statement of Problem: Gutta-percha presents no adhesion to the tooth structure and sealers. Ideally, it should be replaced by a material that offers better sealing in the entire length of the root canal. Purpose: The aim of this study was to compare the coronal microleakage of a root canal filled with different pairs of Gutta-percha (GP), Resilon, Epiphany and AH26. Materials and Method: For this study, 130 mandibular premolars were chosen. After decoronation and preparation of the root canals of the teeth, they were divided into four experimental groups with 30 teeth each and 2 control groups. Group one was obturated with GP and AH26 sealer, group two with GP and Epiphany sealer, group three with Resilon tips and Epiphany sealer, and group four with Resilon tips and AH26 sealer. All the groups were obturated, using cold lateral condensation. Micro-leakage was tested using a two-chamber bacterial method. The data were subjected to statistical analysis, using a Kaplan-Meier test. Results: The bacterial microleakage test showed no significant difference between groups ( p =0.1718). Conclusion: It is concluded that, in vitro, the epiphany obturation system is as good as gutta-percha sealed with AH26 when compared over 90 days of saliva storage.
Presence of cerebral microbleeds is associated with worse executive function in pediatric brain tumor survivors.

BACKGROUND A specific form of small-vessel vasculopathy-cerebral microbleeds (CMBs)-has been linked to various types of dementia in adults. We assessed the incidence of CMBs and their association with neurocognitive function in pediatric brain tumor survivors. METHODS In a multi-institutional cohort of 149 pediatric brain tumor patients who received cranial radiation therapy (CRT) between 1987 and 2014 at age <21 years and 16 patients who did not receive CRT, we determined the presence of CMBs on brain MRIs. Neurocognitive function was assessed using a computerized testing program (CogState). We used survival analysis to determine cumulative incidence of CMBs and Poisson regression to examine risk factors for CMBs. Linear regression models were used to assess effect of CMBs on neurocognitive function. RESULTS The cumulative incidence of CMBs was 48.8% (95% CI: 38.3-60.5) at 5 years. Children who had whole brain irradiation developed CMBs at a rate 4 times greater than those treated with focal irradiation (P < .001). In multivariable analysis, children with CMBs performed worse on the Groton Maze Learning test (GML) compared with those without CMBs (Z-score -1.9; 95% CI: -2.7, -1.1; P < .001), indicating worse executive function when CMBs are present. CMBs in the frontal lobe were associated with worse performance on the GML (Z-score -2.4; 95% CI: -2.9, -1.8; P < .001). Presence of CMBs in the temporal lobes affected verbal memory (Z-score -2.0; 95% CI: -3.3, -0.7; P = .005). CONCLUSION CMBs are common and associated with neurocognitive dysfunction in pediatric brain tumor survivors treated with radiation.
Vocabulary Teaching in Foreign Language via Audiovisual Method Technique of Listening and Following Writing Scripts

The objective is hereby study is to compare the effects of conventional and audiovisual methods on learning efficiency and success of retention with regard to vocabulary teaching in foreign language. Research sample consists of 21 undergraduate and 7 graduate students studying at Department of French Language Teaching, Kazim Karabekir Faculty of Education, Ataturk University. The methodology applied herein is experimental research. Two groups of 14 were randomly established, one as experimental and one as control group. Experimental group underwent audiovisual method, while conventional vocabulary teaching method, still applied in schools, was applied on the control group. The data was gathered from instructive videos equipped with pedagogical references on the website of TV5 monde, under the title “Enseigner le francais avec Tv 5 Monde” [Learn French with TV5 Monde]. Two practices, namely, “2001-2011: faut-il encore avoir peur du terrorisme” [2001-2011: Should we still fear terrorism? ], “guerres et conflits: vers une privatisation generale? ” [Wars & conflicts: Towards an overall privatisation? ], both at C1 education level, have been selected. Success rates in research data were found out by means of percentage calculations. The resulting values are analysed and interpreted through descriptive and content analysis methodology. According to research outputs, the learners are more successful in efficiency of learning and retention via audiovisual method than through conventional method. Simultaneous action of multiple sense organs and high motivation during learning process are considered as the principal reasons for such success.
Sexual Interest in Children Among an Online Sample of Men and Women

The purpose of the present study was to explore the extent to which men and women in the general population report sexual interest in children and to examine distinct developmental experiences associated with self-reported sexual interest. Participants (262 females and 173 males) were recruited online and completed a questionnaire assessing sexual interest and adverse childhood experiences. Among men, 6% indicated some likelihood of having sex with a child if they were guaranteed they would not be caught or punished, as did 2% of women. Nine percent of males and 3% of females indicated some likelihood of viewing child pornography on the Internet. Overall, nearly 10% of males and 4% of females reported some likelihood of having sex with children or viewing child pornography. Males and females with any sexual interest in children reported higher likelihoods of engaging in other antisocial or criminal behaviors and also reported more dysfunctional childhoods (i.e., histories of sexual abuse, insecure parent–child attachments). Theoretical implications of the findings and suggestions for preventing the sexual victimization of children are provided.