Miracle-dz/UniFAR-FTUs huggingface dataset:
Application of Ambiguous Analysis for Determining Recent Infections of HIV-1 in a China Men Who Had Sex with Men Population

Objective: To distinguish HIV-1 recent infection (≤ 300 days) from long-term HIV-1 infection (>300 days) in China men who had sex with men (MSM) population. We analyzed the change over time in the proportion of ambiguous nucleotides in patient plasma sequences. We hypothesized that this method could be used to determine recent infections. Methods: HIV-1 sequences and clinical data of MSM were collected from June 2007 to September 2010. All the sequences were obtained by single genome amplification and sequencing. HIV-ambi-count was used to calculate the proportion of ambiguous nucleotides, and the optimal cut-off values to identify recent infection were established using receiver operator characteristic analysis (ROC). Results: A total of 188 sequences from 150 patients were collected (38 patients were sampled twice at different time points), consisting of 118 sequences of subtype CRF01_AE and 70 sequences of subtype B. The optimal cut-off values for determination of early HIV-1 infection in subtypes CRF01_AE and B were 0.31% and 0.347%, respectively. The sensitivity, specificity, positive and negative predictive values were 76.5%, 55%, 89.3% and 32.4% for subtype CRF01-AE (P=0.005), 80.6%, 62.5%, 94.3% and 29.4% for subtype B (P=0.017), respectively. The area under the ROC curve (AUCROC) was 0.652 (95% CI, 0.520-0.783, P=0.03) and 0.75 (95% CI, 0.622-0.878, P=0.022) for subtype CRF01-AE and B, respectively. Conclusions: The proportion of ambiguous nucleotides may be a good marker to distinguish recent infection from long-term HIV-1 infection with high positive predictive value in the China MSM population.
Stakeholder analysis of a retirement village development in Australia: insights from an interdisciplinary workshop

In Australia, the retirement village is regarded as a viable accommodation option for the fast-growing population of older people. Given that diverse stakeholders are involved in the village development process, a comprehensive stakeholder analysis, especially understanding stakeholders' concerns and expectations, is of critical importance to project success. This paper describes a stakeholder analysis based on a typical retirement village. The main methods utilized in this research were case study and an interdisciplinary workshop comprising intensive work sessions and cross-functional review. The participants of this 2014 Brisbane workshop included four village managers from an Australian retirement village developer and eight academics from diverse disciplines from a large university. Through this workshop, 24 village stakeholders and their specific concerns and expectations were identified. Results suggest that both concerns and expectations of these stakeholders are multidimensional and vary considerably, and the concerns and expectations of different stakeholders have complex relationships. Implications for a retirement village development are also proposed. The findings of the study serve as a valuable reference for developers' understanding of stakeholder concerns and expectations, and for taking corresponding actions in the final stages of the retirement village development.
Why Global? Diagnosing the Globalization Literature Within a Political Economy of Higher Education

This article examines the assumed factuality of globalization in light of its persistent conceptual incoherence. Through a diagnosis of five reoccurring ambiguities within the globalization literature, I argue that the concept of globalization lacks an empirical referent. Scholars writing on globalization overcome this absence by asserting that some things (the Internet, McDonald's, etc.) and not others (genocide in Rwanda, refugee camps, etc.) are essentially “global. ” It turns out, however, that who is positioned to posit some things (and not others) as “global,” and therefore posit the foundation for a theory of globalization, is shaped by a highly asymmetrical political economy of knowledge production. In particular, some scholars—usually in North American and European universities—are materially better positioned to produce knowledge about globalization than many of their colleagues in postcolonial countries. The seemingly arbitrary positing of some things as “global,” therefore, should be understood as a symptom of the highly unequal social relations in which knowledge about globalization is produced.
Bacteriological and Immunological Profiling of Meconium and Fecal Samples from Preterm Infants: A Two-Year Follow-Up Study

An abnormal colonization pattern of the preterm gut may affect immune maturation and exert a long-term influence on the intestinal bacterial composition and host health. However, follow-up studies assessing the evolution of the fecal microbiota of infants that were born preterm are very scarce. In this work, the bacterial compositions of fecal samples, obtained from sixteen 2-year-old infants were evaluated using a phylogenetic microarray; subsequently, the results were compared with those obtained in a previous study from samples of meconium and feces collected from the same infants while they stayed in the neonatal intensive care unit (NICU). In parallel, the concentration of a wide range of cytokines, chemokines, growth factors and immunoglobulins were determined in meconium and fecal samples. Globally, a higher bacterial diversity and a lower interindividual variability were observed in 2-year-olds’ feces, when compared to the samples obtained during their first days of life. Hospital-associated fecal bacteria, that were dominant during the NICU stay, seemed to be replaced, two years later, by genera, which are usually predominant in the healthy adult microbiome. The immune profile of the meconium and fecal samples differed, depending on the sampling time, showing different immune maturation statuses of the gut.
The Impact of Education, Economy and Culture on Entrepreneurial Motives, Barriers and Intentions: A Comparative Study of the United States and Turkey

This study incorporates three primary perspectives used in international comparisons of entrepreneurial intentions—culture, economic conditions and education—in a study of attitudes toward entrepreneurship. Using samples drawn from two countries with distinctly different cultures, economies and education—Turkey and the United States—we develop and test hypotheses regarding the impact of these factors on entrepreneurial intentions and on perceptions of motives and barriers regarding entrepreneurship. For motive and barriers, we discuss and distinguish between intrinsic and extrinsic factors. We observe a number of significant differences between the two sample groups and significant relationships between explanatory factors, intentions and motives and barriers. We discuss the implications of the study for entrepreneurship education and for future research.
Survey of mentally retarded males for cutis verticis gyrata and chromosomal fragile sites.

microcephaly, and typical CVG with 4 rugae running in an anteroposterior direction over the vertex. He had no other minor anomalies, no history of seizure activity, and his CVG developed after puberty. The family history was unremarkable. Cytogenetic studies from this patient of 210 metaphases (100 cells grown in
The acute effects of ethanol and acetaldehyde on rates of protein synthesis in type I and type II fibre-rich skeletal muscles of the rat.

Young rats were injected with either ethanol (75 mmol/kg), acetaldehyde (2.8 mmol/kg) or isovolumetric amounts of NaCl (0.15 mol/l, i.e. controls) with or without inhibitors of alcohol dehydrogenase (4-methylpyrazole) or aldehyde dehydrogenase (cyanamide). After 2.5 hr, fractional rates of protein synthesis (i.e. ks) in the soleus (Type I fibre-rich) and plantaris (Type II fibre-rich) muscles were measured. Ethanol alone reduced ks in both soleus and plantaris muscles, by approx. 25%. Pretreatment of ethanol-dosed rats with 4-methylpyrazole raised plasma ethanol levels and reduced ks in the soleus and plantaris by approx. 35%. Pretreatment of ethanol-dosed rats with cyanamide also increased plasma ethanol and further potentiated the effects of ethanol by reducing ks in the soleus and plantaris by approx. 65%. Acetaldehyde alone reduced ks by approx. 15%, and this effect was not significantly altered by 4-methylpyrazole pretreatment. In some instances, the plantaris was slightly more sensitive to ethanol and acetaldehyde than the soleus. Similar conclusions were derived when data were expressed relative to either RNA or DNA. The data thus suggest that the ethanol-induced inhibition of skeletal muscle protein synthesis may possibly be independently mediated by both ethanol and acetaldehyde.
Why Is 10 Past 10 the Default Setting for Clocks and Watches in Advertisements? A Psychological Experiment

Have you ever noticed that in watch advertisements the time is usually set at 10:10? The reasons and psychological effects of this default time setting are elusive. In Experiment 1, we hypothesized that watches showing a time setting resembling a smiling face (10:10) would enhance emotional valence and intention to buy compared to a neutral time setting (11:30), whereas a time setting resembling a sad face (8:20) would have the opposite effect. Moreover, we investigated a possible interaction effect with the gender of the participants. In Experiment 2, we directly tested the hypotheses that watches set at 10:10 resemble a smiling face, whereas watches set at 8:20 resemble a sad face. The data of the first experiment reveal that watches set at 10:10 showed a significant positive effect on the emotion of the observer and the intention to buy. However, watches set at 8:20 did not show any effect on the emotion or the intention to buy. Moreover, watches set at 10:10 induced in women significantly stronger ratings of pleasure than in men. The data of the second experiment show that participants consistently perceive high resemblance between watches set at 10:10 and a smiling face as well as high resemblance between watches set at 8:20 and a sad face. This study provides for the first time empirical evidence for the notion that using watches with a time setting resembling a smiling face (like 10:10) can positively affect the emotional response of the observers and their evaluation of a seen watch, even though they are not aware of the fact that the shown time setting is inducing this effect. Practical implications of the observed findings and alternative explanations are discussed.
Shifting positions in physical education – notes on otherness, sameness, absence and presence

This article examines the experiences of the researched and the researcher using ethnographic data from interviews with students (13–14-year-olds) and teachers and from participant observation in physical education classes at a Finnish secondary school. Erving Goffman's dramaturgical perspective is used as a frame of reference. In this (manu)script it is applied to feminist researchers' notions of power relations and agency in ethnographic interviewing. Ethnographic dramaturgy is discussed at a theoretical and empirical level. It is argued that doing feminist ethnography is letting the audience get behind the scenes of the research, by, for example, analysing field notes or by studying the shifting balance of power during an interview.
Life Course Analysis—The Courage to Search for Something More

Abstract In this paper we discuss middle-to-late life issues of the transgender and intersex communities. We demonstrate that these mid-to-late life issues are richly complex, full of courage, coping, risk, and resilience, and are grounded in a socio-ecological landscape of systemic actual and perceived violence and abuse. We examine how this socio-ecological environment affects the “normative” mid-life cycle processes. Practical examples are drawn from the author's field interviews and survey research over the past decade. We close by examining the effects of such a landscape on the middle-age life stage and examine its potential ramifications for old age as well.
Energy harvesting for relay-assisted communications

In this paper, we examine the problem of throughput maximization in an energy-harvesting two-hop amplify-and-forward relay network. This problem is investigated over a finite time horizon and in an online setting, where the causal knowledge of the harvested energy and that of fading are available. We use Markov decision process (MDP) formulation to present a mathematically tractable solution to the throughput maximization problem. In this solution, optimal power-use policy is obtained using backward induction algorithm of the corresponding discrete dynamic programming problem. We also present properties of the optimal policy for an important special case, where the power control at transmitters is limited to on-off switching. These properties facilitate the implementation of the MDP based solution. Our numerical simulations show that the proposed method outperforms existing solutions to this problem.
Dietary strategies of immunomodulation in infants at risk for celiac disease

Celiac disease is an inflammatory disorder of the small intestine, triggered by the ingestion of gluten proteins contained in wheat, barley or rye, in genetically susceptible individuals. This disorder is considered to be mainly mediated by cellular immunity and restricted to the human leucocyte antigen-DQ presentation of gluten-derived toxic peptides to T-cells. Moreover, the involvement of innate immunity has been recently demonstrated to be necessary also for the development of intestinal tissue damage. Genetic susceptibility accounts for an uncertain proportion of the disease risk and gluten introduction works as the precipitating factor. However, currently, the research interest is also focused on environmental factors and gene–environment interactions, especially during the first months of life, which might help explain the onset of the disease. Infectious and dietary factors that could modulate the immune response orientating it either towards tolerance or intolerance/autoimmunity are the focus of primary attention. A significant number of studies have looked into the protective effect of breast-feeding against the disease. It is generally accepted that breast-feeding during the introduction of dietary gluten and increasing the duration of breast-feeding are associated with reduced risk of developing celiac disease. However, it is still not fully established whether breast-feeding truly protects with permanent tolerance acquisition or only reduces the symptoms and delays the diagnosis. Moreover, the timing and dose of gluten introduction also seem to be relevant and long-term prospective cohort studies are being carried out in order to elucidate its role in celiac disease development.
Implementation of a vascular access quality programme improves vascular access care.

INTRODUCTION In the Netherlands an access quality improvement plan (QIP) was introduced by vascular access coordinators (VAC) with the aim to decrease vascular access-related complications by preemptive intervention of malfunctioning accesses. A vascular access QIP was established in 24 centres (46% of all Dutch facilities) and a structural multidisciplinary vascular access meeting was instituted. In these centres, including 2300 patients, a protocol for enhancement of fistula creation and access surveillance programme was implemented, with instruction of physicians and nurses, and rounds to discuss complications and evaluate vascular access interventions. The number and type of vascular access, permanent catheters, thrombosis rates and number of interventions were evaluated at the start and end of the study period. RESULTS After the surveillance programme, the number of autogenous arterio-venous fistulas (AVFs) had increased significantly from 69 to 77% (P < 0.01), while the use of temporary subclavian vein catheters declined (34% vs 11%) (P < 0.01), with a substantially higher percentage of jugular vein catheters (from 23 to 35%). Interventional treatment of malfunctioning accesses by percutaneous transluminal angioplasty (PTA) (from 0.39 to 0.50 patient/year; P < 0.001)) and surgical revisions (from 0.06 to 0.12 per patient/year; P < 0.001) also increased. CONCLUSION These data demonstrate that a vascular access QIP resulted in placement of more autogenous AVFs, increased number of PTAs and surgical interventions. These findings suggest that a vascular access care QIP is worthwhile to improve dialysis patients' care and access morbidity.
Retinoblastoma: the disease, gene and protein provide critical leads to understand cancer.

Retinoblastoma has contributed much to the understanding of cancer. The protein product of the RB gene, pRB, is a multifaceted regulator of transcription which controls the cell cycle, differentiation and apoptosis in normal development of specific tissues. Elucidating the mechanisms in which pRB plays a critical role will enable novel therapies and strategies for prevention, not only for retinoblastoma, but for cancer in general.
Fast implementation of AES cryptographic algorithms in smart cards

The National Institute of Standards and Technology (NIST) of US announced Rijndael algorithm as the advanced encryption standard (AES) in October 2000, Despite AES surpassing in security the data encryption standard (DES), it is still rare to be implemented in smart cards, due to the reason of deficient AES coprocessors. Here a chip operation system (COS) called NexCard, which derived from Microsoft's Windows COS, is used as the AES implementation platform. After a suitable COS architecture design for AES and methodology of efficient memory usage, the simulation result shows that direct embedding AES encryption attains 0.56 ms at system clock 15 MHz on the INFINEON SLE66CX322P chip without existence of coprocessor. Corresponding to the development needs in smart card cryptographic algorithm implementations, and different level of the security design specifications, a concept to conjoin numbers of algorithms into single smart card called cipher system on demand (CSOD) method is accomplished in this study concurrently. This is a method utilizing the multiapplication capability of NexCard v2.0 to execute the same AES algorithm as an on-card applet. Although the performance of CSOD is not as good as AES embedded method, CSOD can provide the same result in the situation of adaptability and extendibility.
The Discourse of Global Compassion: The Audience and Media Reporting of Human Suffering

The article focuses on the development of a global discourse of compassion, which has grown in the intersection between politics, humanitarian organizations, the media and the public. In the media there is a growing focus on distant victims of civil wars, genocide, massacres and other violence against civil populations. In the critical media debate it is a common view that the audience is left unmoved by the pictures of distant death and pain. The article presents audience studies, which show a two-sided effect of global compassion on the one hand and indifference on the other. It is shown that compassion is often a more female reaction while indifference is more common among male audiences. It is further shown that there are different forms of compassion as well as different forms of indifference. The results challenge or strongly modulate the thesis about a pronounced compassion fatigue among people in general.
Graph Problems Arising from Wavelength-Routing in All-Optical Networks

We survey the theoretical results obtained for wavelength routing in al l-optical networks, present some new results and propose several open problems. In all-optical networks the vast band- width available is utilized through wavelength division multiplexing: a single physical optical link can carry several logical signals, provided that they are transmitted on dif ferent wavelengths. The information, once transmitted as light, reaches its destination withou t being converted to electronic form in between, thus reaching high data transmission rates. We consider both networks with arbi- trary topologies and particular networks of practical interest.
Expectation Propagation for approximate Bayesian inference

This paper presents a new deterministic approximation technique in Bayesian networks. This method, "Expectation Propagation," unifies two previous techniques: assumed-density filtering, an extension of the Kalman filter, and loopy belief propagation, an extension of belief propagation in Bayesian networks. Loopy belief propagation, because it propagates exact belief states, is useful for a limited class of belief networks, such as those which are purely discrete. Expectation Propagation approximates the belief states by only retaining expectations, such as mean and varitmce, and iterates until these expectations are consistent throughout the network. This makes it applicable to hybrid networks with discrete and continuous nodes. Experiments with Gaussian mixture models show Expectation Propagation to be donvincingly better than methods with similar computational cost: Laplace's method, variational Bayes, and Monte Carlo. Expectation Propagation also provides an efficient algorithm for training Bayes point machine classifiers.
Risk Factors for the First Episode of Klebsiella pneumoniae Resistant to Carbapenems Infection in Critically Ill Patients: A Prospective Study

Objective. To identify risk factors for the first episode of Klebsiella Pneumonia resistant to carbapenems (KPRC) infection in critically ill patients. Design, Setting, and Methods. This prospective cohort study was conducted in a 12-bed general Intensive Care Unit (ICU) in a University Hospital on ICU patients who required mechanical ventilation (MV) for >48 hours during a 12-month period. Clinical and microbiologic data were studied. Characteristics of KPRC patients were compared with those of critically ill patients who presented nonmultidrug resistant (MDR) bacterial infections or no documented infection at all. Results. Twenty-five patients presented KPRC infection, 18 presented non-MDR bacterial infection, and 39 patients presented no infection. Compared to patients without documented infection or infected by non MDR bacteria, patients with KPRC infection had received more frequently or for longer duration antibiotics against Gram-negative bacteria (carbapenems, colistin P < 0.05). Duration of colistin administration prior to KPRC isolation was independently associated with increased frequency of KPRC infection (odds ratio, 1.156 per day; 95% confidence interval, 1.010 to 1.312; P = 0.025). KPRC patients stayed longer in the ICU and received mechanical ventilation and sedation for longer periods and presented increased mortality (P < 0.05). Conclusion. KPRC infection is an emerging problem which might be more common in patients with previous use of antibiotics and especially colistin.
Alignment of Biological Apatite Crystallites at First Molar in Human Mandible Cortical Bone

Abstract The aim of this study was to quantitatively clarify the c-axis alignment of biological apatite (BAp) crystallites (hereafter referred to as BAp alignment) in the cortical bone of the human mandible first molar. Six mandible specimens were collected from the cadavers of six dentulous Japanese adults (mean age, 63.0±12.1 years) held at the Department of Anatomy, Tokyo Dental College. A microbeam x-ray diffraction system was used to determine BAp alignment in the mesiodistal direction. Bone mineral density (BMD) was also measured using 3-dimensional trabecular structure measurement software. The results showed that the degree of BAp alignment in the mesiodistal direction was low in the alveolar area and high at the base of the mandible, suggesting that BAp alignment in the alveolar area is affected by occlusal force. Moreover, it was observed that the correlation between BAp alignment and BMD was small, indicating that BAp alignment and BMD could be independent factors. Therefore, determining BAp alignment was important in the evaluation of bone quality, including bone strength.