Miracle-dz/UniFAR-FTUs huggingface dataset:
Multitemporal Observations of Sugarcane by TerraSAR-X Images

The objective of this study is to investigate the potential of TerraSAR-X (X-band) in monitoring sugarcane growth on Reunion Island (located in the Indian Ocean). Multi-temporal TerraSAR data acquired at various incidence angles (17°, 31°, 37°, 47°, 58°) and polarizations (HH, HV, VV) were analyzed in order to study the behaviour of SAR (synthetic aperture radar) signal as a function of sugarcane height and NDVI (Normalized Difference Vegetation Index). The potential of TerraSAR for mapping the sugarcane harvest was also studied. Radar signal increased quickly with crop height until a threshold height, which depended on polarization and incidence angle. Beyond this threshold, the signal increased only slightly, remained constant, or even decreased. The threshold height is slightly higher with cross polarization and higher incidence angles (47° in comparison with 17° and 31°). Results also showed that the co-polarizations channels (HH and VV) were well correlated. High correlation between SAR signal and NDVI calculated from SPOT-4/5 images was observed. TerraSAR data showed that after strong rains the soil contribution to the backscattering of sugarcane fields can be important for canes with heights of terminal visible dewlap (htvd) less than 50 cm (total cane heights around 155 cm). This increase in radar signal after strong rains could involve an ambiguity between young and mature canes. Indeed, the radar signal on TerraSAR images acquired in wet soil conditions could be of the same order for fields recently harvested and mature sugarcane fields, making difficult the detection of cuts. Finally, TerraSAR data at high spatial resolution were shown to be useful for monitoring sugarcane harvest when the fields are of small size or when the cut is spread out in time. The comparison between incidence angles of 17°, 37° and 58° shows that 37° is more suitable to monitor the sugarcane harvest. The cut is easily detectable on TerraSAR images for data acquired less than two or three months after the cut. The radar signal decreases about 5dB for images acquired some days after the cut and 3 dB for data acquired two month after the cut (VV-37°). The difference in radar signal becomes negligible (<1 dB) between harvested fields and mature canes for sugarcane harvested since three months or more.
Physiologically based pharmacokinetic and pharmacodynamic modeling of an antagonist (SM‐406/AT‐406) of multiple inhibitor of apoptosis proteins (IAPs) in a mouse xenograft model of human breast cancer

The inhibitors of apoptosis proteins (IAPs) are a class of key apoptosis regulators overexpressed or dysregulated in cancer. SM‐406/AT‐406 is a potent and selective small molecule mimetic of Smac that antagonizes the inhibitor of apoptosis proteins (IAPs). A physiologically based pharmacokinetic and pharmacodynamic (PBPK‐PD) model was developed to predict the tissue concentration–time profiles of SM‐406, the related onco‐protein levels in tumor, and the tumor growth inhibition in a mouse model bearing human breast cancer xenograft. In the whole body physiologically based pharmacokinetic (PBPK) model for pharmacokinetics characterization, a well stirred (perfusion rate‐limited) model was used to describe SM‐406 pharmacokinetics in the lung, heart, kidney, intestine, liver and spleen, and a diffusion rate‐limited (permeability limited) model was used for tumor. Pharmacodynamic (PD) models were developed to correlate the SM‐406 concentration in tumor to the cIAP1 degradation, pro‐caspase 8 decrease, CL‐PARP accumulation and tumor growth inhibition. The PBPK‐PD model well described the experimental pharmacokinetic data, the pharmacodynamic biomarker responses and tumor growth. This model may be helpful to predict tumor and plasma SM‐406 concentrations in the clinic. Copyright © 2013 John Wiley & Sons, Ltd.
Capturing Teachers’ Generative Change: A Follow-Up Study of Professional Development in Mathematics

This study documents how teachers who participated in a professional development program on understanding the development of students’ mathematical thinking continued to implement the principles of the program 4 years after it ended. Twenty-two teachers participated in follow-up interviews and classroom observations. All 22 teachers maintained some use of children’s thinking and 10 teachers continued learning in noticeable ways. The 10 teachers engaged in generative growth (a) viewed children’s thinking as central, (b)possessed detailed knowledge about children’s thinking, (c) discussed frameworks for characterizing the development of children’s mathematical thinking, (d) perceived themselves as creating and elaborating their own knowledge about children’s thinking, and (e) sought colleagues who also possessed knowledge about children’s thinking for support. The follow-up revealed insights about generative growth, sustainability of changed practice and professional development.
Human ALKBH4 Interacts with Proteins Associated with Transcription

The Fe(II)- and 2-oxoglutarate (2OG)-dependent dioxygenase AlkB from E. coli is a demethylase which repairs alkyl lesions in DNA, as well as RNA, through a direct reversal mechanism. Humans possess nine AlkB homologs (ALKBH1-8 and FTO). ALKBH2 and ALKBH3 display demethylase activities corresponding to that of AlkB, and both ALKBH8 and FTO are RNA modification enzymes. The biochemical functions of the rest of the homologs are still unknown. To increase our knowledge on the functions of ALKBH4 and ALKBH7 we have here performed yeast two-hybrid screens to identify interaction partners of the two proteins. While no high-confidence hits were detected in the case of ALKBH7, several proteins associated with chromatin and/or involved in transcription were found to interact with ALKBH4. For all interaction partners, the regions mediating binding to ALKBH4 comprised domains previously reported to be involved in interaction with DNA or chromatin. Furthermore, some of these partners showed nuclear co-localization with ALKBH4. However, the global gene expression pattern was only marginally altered upon ALKBH4 over-expression, and larger effects were observed in the case of ALKBH7. Although the molecular function of both proteins remains to be revealed, our findings suggest a role for ALKBH4 in regulation of gene expression or chromatin state.
Random Walks in Random Environments

We consider Markov chains on the lattice Zd or on subset, which have site dependent transition probabilities. We denote by P a set of probability distributions on Zd. P will always contain only probabilities on a xed nite subset of Zd; for instance e 2 Zd : jej = 1 ; but we will also consider other situations. A eld of transition probabilities is described by an element ! 2 def = PZd ; ! = (! x)x2Zd : F is the appropriate product - eld on : The transition probabilities of our random walk in random environment(RWRE for short) are then given by
Support for European Union Environmental Policy by Citizens of EU-Member and Accession States

In a first step we reconstruct the emergence and content of European Union environmental policies and their underlying normative ideas. Th ese policies have become increasingly important since the 1970s such that today the EU expects member states actively to protect the natural environment even at the price of less economic freedom and higher financial costs. We then analyze the extent to which citizens support the idea of protecting the environment. Overall the approval rating for the EU ecological ideas is rather high, and environmental protection is an integral component of European citizens’ values. Nevertheless, not all countries support this to the same degree. Citizens of EU-15 countries show higher levels of support for having the environment take precedence over economic claims than do citizens in Accession I and II country groups and in Turkey. As regression analysis shows, the level of support depends on several factors. Th e most important ones are a country’s level of economic modernization and its citizens’ postmaterial value orientation.
Nordic in nature: friluftsliv and environmental connectedness

This study explored the question of whether a relationship exists between the Nordic cultural idea of friluftsliv and the psychological construct of environmental connectedness (EC). This quantitative study employed a correlational design with existing data from the Swedish Outdoor Recreation in Change national survey. Results indicate that there is a significant and meaningful relationship between friluftsliv, operationally defined as nature-based outdoor recreation participation, and EC even when controlling for other predictor variables. In addition, research findings indicate that age group moderates this relationship with one group exception. It was also found that activity participation by respondents shows a correlation with both EC and age group. Implications of this study support a cultural understanding of nature-based outdoor recreation and an awareness of the important role of access to nature as an essential component of nature-based outdoor recreation. Age group differences supported a variety of implications and recommendations for future research. A consideration of how the results may have implications for environmental education and sustainability efforts were explored.
Judging the Importance of Constant and Variable Candidate Causes: A Test of the Power PC Theory

In two causal induction experiments subjects rated the importance of pairs of candidate causes in the production of a target effect; one candidate was present on every trial (constant cause), whereas the other was present on only some trials (variable cause). The design of both experiments consisted of a factorial combination of two values of the variable cause's covariation with the effect and three levels of the base rate of the effect. Judgements of the constant cause were inversely proportional to the level of covariation of the variable cause but were proportional to the base rate of the effect. The judgements were consistent with the predictions derived from the Rescorla-Wagner (1972) model of associative learning and with the predictions of the causal power theory of the probabilistic contrast model (Cheng, 1997) or “power PC theory”. However, judgements of the importance of the variable candidate cause were proportional to the base rate of the effect, a phenomenon that is in some cases anticipated by the power PC theory. An alternative associative model, Pearce's (1987) similarity-based generalization model, predicts the influence of the base rate of the effect on the estimates of both the constant and the variable cause.
Sign Facilitation in Word Recognition

The purpose of this article was a dual one: first, to provide a comprehensive literature review, and second, to report one study to extend that literature. That study investigated whether signs from the Sign Language of the Netherlands would facilitate word recognition by deaf children. Participants were 6-to 10-year-old deaf children who attended a school for the deaf at which they received bilingual education. The mean hearing loss was 104 dB. Participants attended a training in which they were taught to match written words with pictures. Before and after training, they were tested in word recognition by means of a computer-based test. Results indicated a significant increase in accuracy of word recognition after training. If words were learned through speech, accompanied by the relevant sign, accuracy of word recognition increased to a greater extent than if words were learned solely through speech.
The predictability of enrolment and first‐year university results from secondary school performance: the New Zealand National Certificate of Educational Achievement

This study investigates the predictive correlations between results from the New Zealand National Certificate of Educational Achievement (NCEA), a standards‐based qualification, and university grade point averages achieved by first‐year students in one large New Zealand University (and, for comparison purposes, also presents correlations from the Cambridge International Examinations [CIE], an international norm‐referenced system delivered in New Zealand, and university grade point averages achieved by first‐year students who entered with that qualification). The study then evaluates alternative models for university entrance, using different attributes of the qualifications for possible entry criteria, and ascertains the implications of the best of these models for different groups of students. The best alternative model gives greater weight to excellence and merit in NCEA results, and less weight to credit accumulation at minimum pass rates. A combination of this alternative model and the current model provides a merit‐based admissions system which would potentially increase the number of students from groups under‐represented in university education in New Zealand (students from Maori and Pacific ethnicities and from schools in lower socio‐economic communities), who are admitted with no necessary decline in the success rate during first‐year university study.
To Monitor or Not to Monitor

An untested assumption in the gainsharing and group incentive literatures is that peer monitoring is an activity that employees will engage in, and this behavior will be supported by their managers. This study tests that assumption by examining how managers respond (via performance ratings of workers) to peer monitoring under two different pay conditions—traditional merit pay and merit pay with gainsharing. Data from 203 employees in a custom brokerage and freight-forwarding services firm suggest that observational monitoring (i.e., noticing coworkers' behavior) is positively associated with manager ratings of workers' performance under both pay conditions. However, advisory monitoring (i.e., reacting to coworkers' behavior) is positively related to manager ratings of workers' performance under gainsharing and negatively related to manager ratings of workers' performance under traditional merit pay. Implications of these findings for managers are discussed.
Probiotics in Pediatrics – Properties, Mechanisms of Action, and Indications

Probiotics have been the topic of many studies over the past 20 years. Metchnikoff and Tissier (Metchnikoff 1907, Tissier, 1906) were the first to make scientific suggestions concerning the probiotic use of bacteria. They suggested that these bacteria could be administered to patients with diarrhea to help restore a healthy gut flora. Fuller (1989) in order to point out the microbial nature of probiotics redefined the word as “A live microbial feed supplement which beneficially affects the host animal by improving its intestinal balance. ” The most recent but probably not the last definition is “live microorganisms, which when consumed in adequate amounts, confer a health effect on the host”( Guarner and Schaafsma,1998). In the last 20 years however, research in the probiotic area has progressed considerably and significant advances have been made in selection and characterization of specific probiotic cultures. Most of the studies aim to investigate the physiological and functional properties of various probiotic strains, the mechanisms of action and the indications for human use and health benefits.
Revisiting How and When Perceived Organizational Support Enhances Taking Charge

Current theory and research suggest a positive linear relationship between perceived organizational support (POS) and employees’ taking charge, or change-suggesting, behaviors. Via a sample of 89 subordinate-supervisor dyads, we hypothesize and test an inverted U-shaped relationship between employees’ POS and their taking charge behaviors and the likelihood that this curvilinear pattern is accentuated when employees anticipate costs related to their taking charge. Results support both of these patterns. We conclude by discussing our findings’ implications regarding future needed sensitivity on the part of managers as well as management scholars regarding how to gauge optimal levels of POS.
Paraquat Intoxication in Subjects Who Attempt Suicide: Why They Chose Paraquat

Background/Aims Paraquat (PQ) has been used in suicide attempts; an estimated 2,000 toxic ingestions occur annually, with 60-70% mortality. We sought to determine why PQ is such a common agent for suicide attempts in Korea. Methods We analyzed 250 cases (143 males, 107 females) of attempted suicide by PQ ingestion from January to December 2007. The procurement of the PQ was divided into two categories: purchased and preexisting. Results Men were more likely to have purchased PQ than women (66% vs. 22%, p=0.042). Additionally, men were more likely to be unmarried (n=34, 23.9% vs. n=10, 9.3%) or divorced or separated (n=16, 11.3% vs. n=5, 4.6%) than the women (p<0.001). The group who intentionally selected PQ (38.4%) consisted of 96 cases (54 males, 42 females) and the group who did not intentionally select PQ (61.6%) included 154 cases (89 males, 65 females). The incidence of PQ purchase was higher in the intentional selection PQ group (46.9% vs. 18.2%, p<0.01). Conclusions Only 38% of patients who attempted suicide with PQ intentionally selected PQ. Thus, greater control of PQ availability is needed, especially in patients at risk.
Enhanced oral bioavailability of fenofibrate using polymeric nanoparticulated systems: physicochemical characterization and in vivo investigation

Background The intention of this research was to prepare and compare various solubility-enhancing nanoparticulated systems in order to select a nanoparticulated formulation with the most improved oral bioavailability of poorly water-soluble fenofibrate. Methods The most appropriate excipients for different nanoparticulated preparations were selected by determining the drug solubility in 1% (w/v) aqueous solutions of each carrier. The polyvinylpyrrolidone (PVP) nanospheres, hydroxypropyl-β-cyclodextrin (HP-β-CD) nanocorpuscles, and gelatin nanocapsules were formulated as fenofibrate/PVP/sodium lauryl sulfate (SLS), fenofibrate/HP-β-CD, and fenofibrate/gelatin at the optimized weight ratios of 2.5:4.5:1, 1:4, and 1:8, respectively. The three solid-state products were achieved using the solvent-evaporation method through the spray-drying technique. The physicochemical characterization of these nanoparticles was accomplished by powder X-ray diffraction, differential scanning calorimetry, scanning electron microscopy, and Fourier-transform infrared spectroscopy. Their physicochemical properties, aqueous solubility, dissolution rate, and pharmacokinetics in rats were investigated in comparison with the drug powder. Results Among the tested carriers, PVP, HP-β-CD, gelatin, and SLS showed better solubility and were selected as the most appropriate constituents for various nanoparticulated systems. All of the formulations significantly improved the aqueous solubility, dissolution rate, and oral bioavailability of fenofibrate compared to the drug powder. The drug was present in the amorphous form in HP-β-CD nanocorpuscles; however, in other formulations, it existed in the crystalline state with a reduced intensity. The aqueous solubility and dissolution rates of the nanoparticles (after 30 minutes) were not significantly different from one another. Among the nanoparticulated systems tested in this study, the initial dissolution rates (up to 10 minutes) were higher with the PVP nanospheres and HP-β-CD nanocorpuscles; however, neither of them resulted in the highest oral bioavailability. Irrespective of relatively retarded dissolution rate, gelatin nanocapsules showed the highest apparent aqueous solubility and furnished the most improved oral bioavailability of the drug (~5.5-fold), owing to better wetting and diminution in crystallinity. Conclusion Fenofibrate-loaded gelatin nanocapsules prepared using the solvent-evaporation method through the spray-drying technique could be a potential oral pharmaceutical product for administering the poorly water-soluble fenofibrate with an enhanced bioavailability.
Short-Term Prognosis of Mechanically Ventilated Patients With Guillain–Barré Syndrome Is Worsened by Corticosteroids as an Add-On Therapy

AbstractIntravenous immunoglobulin (IVIg) has been proven most effective in treating Guillain–Barré syndrome (GBS). Corticosteroids as an add-on therapy have been prescribed in severe GBS cases. However, the efficacy of intravenous corticosteroids combined with IVIg in dealing with severe GBS remains unclear. We explored the therapeutic effects of different therapeutic regimens on the short-term prognosis of GBS patients, especially the severe cases.We retrospectively analyzed the clinical data of 527 adult patients with GBS who were prescribed to different treatments from 2003 to 2014. The therapeutic effect of a treatment was evaluated by the improvement of Hughes Functional Grading Scale (HFGS) and Medical Research Council (MRC) sum score.With comparable incidence of infectious complications (P > 0.05), more mechanically ventilated patients were found improvement after IVIg treatment than combination IVIg with intravenous corticosteroids (MRC: 97% vs. 72.4%, P < 0.05; HFGS: 97% vs. 72.4%, P < 0.05). As to bedridden patients without mechanical ventilation, incidence of infectious complications (P > 0.05) and ratio of patients who were improved after IVIg were insignificantly different from the combination therapy (MRC: 89.6% vs. 86.5%; HFGS: 69.6% vs. 61.5%; both P > 0.05), even if the intravenous corticosteroids were initiated within 7 days after onset (P > 0.05). In addition, supportive treatment was sufficient for patients who were able to walk with help (HFGS = 3) and mildly affected (HFGS < 3) when compared with IVIg and intravenous corticosteroids.IVIg is sufficient to GBS patients who are unable to walk (HFGS > 3), while corticosteroids are detrimental for short-term prognosis in mechanically ventilated patients when used in combination with IVIg. Further prospective and randomized studies are warranted to validate this finding.
Awareness of naturalistic action errors in dementia

Abstract Unawareness of deficit is a common feature of degenerative dementia. The present study explored awareness and correction of naturalistic action errors in 54 dementia participants and 10 healthy controls while they performed a series of everyday tasks, such as toast preparation and gift-wrapping. Awareness for everyday task performance and cognitive functioning was also assessed with questionnaire discrepancy scores, and a neuropsychological test protocol was administered. Dementia participants were aware of and corrected a significantly smaller proportion of errors compared to controls (z = 4.59, p < 001). Awareness and correction of action errors was not significantly correlated with the number of naturalistic errors committed, questionnaire discrepancy scores, or neuropsychological test data. Within-group analyses showed awareness differed across error types, such that participants were aware of a greater proportion of substitution and sequence errors compared to omissions, perseverations, and action addition (i.e., utilization behavior) errors (z ≤ −3.2,p≤.002 for all analyses). Taken together these data suggest that error awareness and correction during the course of action is not related to error production or awareness measured via questionnaire discrepancy scores. Rather, direct assessment of error detection and correction may provide novel information about behavioral monitoring that can not be extrapolated from measures of dementia severity or traditional neuropsychological assessment.