Miracle-dz/UniFAR-FTUs huggingface dataset:
Lung protective ventilation strategy for the acute respiratory distress syndrome.

BACKGROUND Patients with acute respiratory distress syndrome and acute lung injury require mechanical ventilatory support. Acute respiratory distress syndrome and acute lung injury are further complicated by ventilator-induced lung injury. Lung-protective ventilation strategies may lead to improved survival. OBJECTIVES To assess the effects of ventilation with lower tidal volume on morbidity and mortality in patients aged 16 years or older affected by acute respiratory distress syndrome and acute lung injury. A secondary objective was to determine whether the comparison between low and conventional tidal volume was different if a plateau airway pressure of greater than 30 to 35 cm H20 was used. SEARCH STRATEGY In our original review, we searched databases from inception until 2003. In this updated review, we searched The Cochrane Central Register of Controlled Trials (CENTRAL), (The Cochrane Library 2006, Issue 3). We updated our search of MEDLINE, EMBASE, CINAHL and the Web of Science from 2003 to 2006. We also updated our search of intensive care journals and conference proceedings; databases of ongoing research, reference lists and 'grey literature' from 2003 to 2006. SELECTION CRITERIA We included randomized controlled trials comparing ventilation using either lower tidal volume (Vt) or low airway driving pressure (plateau pressure 30 cm H2O or less), resulting in tidal volume of 7 ml/kg or less versus ventilation that uses Vt in the range of 10 to 15 ml/kg, in adults (16 years old or older). DATA COLLECTION AND ANALYSIS We independently assessed trial quality and extracted data. Wherever appropriate, results were pooled. We applied fixed- and random-effects models. MAIN RESULTS We found one new study in this update for a total of six trials, involving 1297 patients, which were eligible for inclusion. Mortality at day 28 was significantly reduced by lung-protective ventilation: relative risk (RR) 0.74 (95% confidence interval (CI) 0.61 to 0.88); hospital mortality was reduced: RR 0.80 (95% CI 0.69 to 0.92); overall mortality was not significantly different if a plateau pressure less than or equal to 31 cm H2O in control group was used: RR 1.13 (95% CI 0.88 to 1.45). There was insufficient evidence about morbidity and long term outcomes. AUTHORS' CONCLUSIONS Clinical heterogeneity, such as different lengths of follow up and higher plateau pressure in control arms in two trials, make the interpretation of the combined results difficult. Mortality is significantly reduced at day 28 and at the end of hospital stay. The effects on long-term mortality are unknown, although the possibility of a clinically relevant benefit cannot be excluded.
A Robust Matched Detector

We address the matched detector problem in the case the signal to be detected is imperfectly known. While in the standard detector the signal is known to lie along a particular direction, we consider the case where this direction is known up to additive white Gaussian noise. This somehow amounts to assuming that the signal lies in a cone the aperture of which depends upon the level of uncertainty. We build the associated generalized likelihood ratio (GLR), analyze its statistical properties, indicate how to set the threshold to achieve a given false alarm rate, and how to predict the associated probability of detection. The so-obtained detector reduces to the conventional one when the uncertainty vanishes and we analyze its behavior when the level of uncertainty, which has to be known a priori, is mis-evaluated. It appears that the sensitivity of the detector is quite low with respect to this kind of errors. More importantly several realistic examples are presented that indicate that the proposed detector remains quite efficient when the true signals are far from being of the assumed model and whatever the model of the uncertainty actually is. It is this robustness that makes the detector valuable.
The Pan basic helix-loop-helix proteins are required for insulin gene expression.

The rat I insulin enhancer contains two principal regulatory elements, the Nir and Far motifs of an identical 9-base pair sequence, which function both as positive and negative cis-acting elements. The Nir and Far elements are targets for DNA-binding proteins, which play a predominant role in the selective transcription of the insulin gene in endocrine beta-cells. In vitro DNA-binding studies have demonstrated the ability of several helix-loop-helix (HLH) proteins, including the Pan/E2A proteins, upstream stimulating factor, human beta-HLH factor (rat beta-HLH factor), and E2-2/ITF-2, to bind the Nir and Far enhancer motifs. The presence of the aforementioned different HLH proteins in endocrine beta-cells, all of which display similar binding affinities for the Nir and Far elements in vitro, raises the question of which HLH proteins actively participate in the transcriptional regulation of the rat insulin I gene in pancreatic endocrine beta-cells. To investigate the specific role that Pan proteins play in regulating insulin gene expression, we have created endocrine beta-cell stable integrants that constitutively express Pan antisense transcripts that selectively inhibit endogenous Pan protein synthesis in differentiated beta-cells. We demonstrate that diminished Pan protein levels in beta-cells, caused by Pan antisense transcripts, accompanies a dramatic attenuation of rat insulin gene transcription. We also show that the decrease in Pan protein expression correlates with a specific reduction of the beta-endocrine-specific Nir and Far element-binding activity, insulin enhancer factor 1. (ABSTRACT TRUNCATED AT 250 WORDS)
Sequential optimisation without state space exploration

We propose an algorithm for area optimisation of sequential circuits through redundancy removal. The algorithm finds compatible redundancies by implying values over nets in the circuit. The potentially exponential cost of state space traversal is avoided and the redundancies found can all be removed at once. The optimised circuit is a safe delayed replacement of the original circuit. The algorithm computes a set of compatible sequential redundancies and simplifies the circuit by propagating them through the circuit. We demonstrate the efficacy of the algorithm even for large circuits through experimental results on benchmark circuits.
A Modularized Charge Equalizer Using a Battery Monitoring IC for Series-Connected Li-Ion Battery Strings in Electric Vehicles

In the lithium-ion battery systems for electric vehicles (EVs), a battery management system (BMS) is essential for enhancing the battery's life cycle and safety. As a result, a BMS is required to realize both the effective cell monitoring and balancing. Moreover, individual cell balancing and monitoring circuit with a smaller size are required in a large number of battery cells. To meet these requirements, a modularized charge equalizer using the monitoring integrated circuit (IC) is proposed for EV battery strings. The proposed scheme exhibits efficient charge equalization with simple control of the monitoring IC. In the proposed equalizer, the battery string is modularized into a master module and multiple slave modules. A central equalization converter in the master module is shared by all of the battery cells through the module and cell switches in the slave module, instead of a dedicated charge equalizer for each of the cells. Individual charge equalization can be controlled by the cell monitoring IC in the slave module. With this configuration, the battery monitoring and balancing can be effectively merged into one controller. Moreover, the individual charge equalizer can be effectively implemented without affecting the size or cost based on the numbers of cells. In this paper, a prototype for 88 lithium-ion battery cells is optimally designed and implemented. Experimental results verify that the proposed method exhibits outstanding balancing performance with simple operation methods.
A role for subplate neurons in the patterning of connections from thalamus to neocortex.

During cerebral cortical development, ingrowing axons from different thalamic nuclei select and invade their cortical targets. The selection of an appropriate target is first evident even before thalamic axons grow into the cortical plate: initially axons accumulate and wait below their cortical target area in a zone called the subplate. This zone also contains the first postmitotic neurons of the cerebral cortex, the subplate neurons. Here we have investigated whether subplate neurons are involved in the process of target selection by thalamic axons by ablating them from specific cortical regions at the onset of the waiting period and examining the subsequent thalamocortical axon projection patterns. Subplate neurons were ablated at the onset of the waiting period by intracortical injections of kainic acid. The effect of the ablation on the thalamocortical projection from visual thalamus was examined by DiI-labeling of the LGN days to weeks following the lesion. At two to four weeks post-lesion, times when LGN axons would have normally invaded the cortical plate, the axons remained below the cortical plate and grew past their appropriate cortical target in an anomalous pathway. Moreover, examination of LGN axons at one week post-lesion, a time when they would normally be waiting and branching within the visual subplate, indicated that the axons had already grown past their correct destination. These observations suggest that visual subplate neurons are involved in the process by which LGN axons select and subsequently grow into visual cortex. In contrast, subplate neurons do not appear to play a major role in the initial morphological development of the LGN itself. Subplate ablations did not alter dendritic growth or shapes of LGN projection neurons during the period under study, nor did it prevent the segregation of retinal ganglion cell axons into eye-specific layers. However, the overall size of the LGN was reduced, suggesting that there may be increased cell death of LGN neurons in the absence of subplate neurons. To examine whether subplate neurons beneath other neocortical areas play a similar role in the formation of thalamocortical connections, subplate neurons were deleted beneath auditory cortex at the onset of the waiting period for auditory thalamic axons. Subsequent DiI labeling revealed that in these animals the majority of MGN axons had grown past auditory cortex instead of innervating it. Taken together these observations underscore a general requirement for subplate neurons throughout neocortex in the process of cortical target selection and ingrowth by thalamic axons. (ABSTRACT TRUNCATED AT 400 WORDS)
Racial Variation in Treatment Preferences and Willingness to Randomize in the Spine Patient Outcomes Research Trial (SPORT)

Study Design. Analysis of baseline data for patients enrolled in Spine Patient Outcomes Research Trial (SPORT), a project conducting three randomized and three observational cohort studies of surgical and nonoperative treatments for intervertebral disc herniation (IDH), spinal stenosis (SpS), and degenerative spondylolisthesis (DS). Objective. To explore racial variation in treatment preferences and willingness to be randomized. Summary of Background Data. Increasing minority participation in research has been a priority at the NIH. Prior studies have documented lower rates of participation in research and preferences for invasive treatment among African-Americans. Methods. Patients enrolled in SPORT (March 2000 to February 2005) that reported data on their race (n = 2,323) were classified as White (87%), Black (8%), or Other (5%). Treatment preferences (nonoperative, unsure, surgical), and willingness to be randomized were compared among these groups while controlling for baseline differences using multivariate logistic regression. Results. There were numerous significant differences in baseline characteristics among the racial groups. Following adjustment for these differences, Blacks remained less likely to prefer surgical treatment among both IDH (White, 55%; Black, 37%; Other, 55%, P = 0.023) and SpS/DS (White, 46%; Black, 30%; Other, 43%; P = 0.017) patients. Higher randomization rates among Black IDH patients (46% vs. 30%) were no longer significant following adjustment (odds ratio [OR] = 1.45, P = 0.235). Treatment preference remained a strong independent predictor of randomization in multivariate analyses for both IDH (unsure OR = 3.88, P < 0.001 and surgical OR = 0.23, P < 0.001) and SpS/DS (unsure OR = 6.93, P < 0.001 and surgical OR = 0.45, P < 0.001) patients. Conclusions. Similar to prior studies, Black participants were less likely than Whites or Others to prefer surgical treatment; however, they were no less likely to agree to be randomized. Treatment preferences were strongly related to both race and willingness to be randomized.
Estimating recent historic abundance from contemporary levels of genetic diversity

Recent historic abundance is an elusive parameter of great importance for conserving endangered species and understanding the pre-anthropogenic state of the biosphere. The number of studies that have used population genetic theory to estimate recent historic abundance from contemporary levels of genetic diversity has grown rapidly over the last two decades. Such assessments often yield unexpectedly large estimates of historic abundance. We review the underlying theory and common practices of estimating recent historic abundance from contemporary genetic diversity, and critically evaluate the potential issues at various estimation steps. A general issue of mismatched spatio-temporal scales between the estimation itself and the objective of the estimation emerged from our assessment; genetic diversity–based estimates of recent historic abundance represent long-term averages, whereas the objective typically is an estimate of recent abundance for a specific population. Currently, the most promising approach to estimate the difference between recent historic and contemporary abundance requires that genetic data be collected from samples of similar spatial and temporal duration. Novel genome-enabled inference methods may be able to utilize additional information of dense genome-wide distributions of markers, such as of identity-by-descent tracts, to infer recent historic abundance from contemporary samples only.
Multidrug Resistance-Associated Proteins: Expression and Function in the Central Nervous System

Drug delivery to the brain is highly restricted, since compounds must cross a series of structural and metabolic barriers to reach their final destination, often a cellular compartment such as neurons, microglia, or astrocytes. The primary barriers to the central nervous system are the blood-brain and blood-cerebrospinal fluid barriers. Through structural modifications, including the presence of tight junctions that greatly limit paracellular transport, the cells that make up these barriers restrict diffusion of many pharmaceutically active compounds. In addition, the cells that comprise the blood-brain and blood-cerebrospinal fluid barriers express multiple ATP-dependent, membrane-bound, efflux transporters, such as members of the multidrug resistance-associated protein (MRP) family, which contribute to lowered drug accumulation. A relatively new concept in brain drug distribution just beginning to be explored is the possibility that cellular components of the brain parenchyma could act as a “second” barrier to brain permeation of pharmacological agents via expression of many of the same transporters. Indeed, efflux transporters expressed in brain parenchyma may facilitate the overall export of xenobiotics from the central nervous system, essentially handing themoff to the barrier tissues. We propose that these primary and secondary barriers work in tandem to limit overall accumulation and distribution of xenobiotics in the central nervous system. The present review summarizes recent knowledge in this area and emphasizes the clinical significance of MRP transporter expression in a variety of neurological disorders.
Application of bio-inspired krill herd algorithm to combined heat and power economic dispatch

This paper presents bio-inspired new krill herd (KH) algorithm for solving combined heat and power economic dispatch (CHPED) optimization task. This algorithm is based on the herding behavior of krill individuals and is very efficient in finding the global optima in shortest possible time. The objective function is defined as the distance of each krill individual from food and the highest density of herd. At any instant, position of a krill individual is dependent on 1) motion induced by surrounding krill, 2) foraging motion of it and 3) its diffusion motion. The algorithm has been illustrated simulating on a test system and the result has been compared with those obtained from particle swarm optimization (PSO), evolutionary programming (EP) and differential evolution (DE). The comparison shows that the solution obtained by this KH method is of better quality than other methods.
Effect of splinting and interproximal contact tightness on load transfer by implant restorations.

STATEMENT OF PROBLEM To circumvent the difficulty of achieving a passive framework fit, some authors have suggested that multiple adjacent implants be restored individually. This protocol requires that each unit be able to withstand mastication forces. Non-splinted restorations have numerous interproximal contacts that require adjustments prior to placement, with an unknown outcome relative to load transfer. PURPOSE This in vitro simulation study examined the effect of splinting and interproximal contact tightness on passivity of fit and the load transfer characteristics of implant restorations. MATERIAL AND METHODS A photoelastic model of a human partially edentulous left mandible with 3 screw-type implants (3.75 x 10 mm) was fabricated. For non-splinted restorations, individual crowns were fabricated on 3 custom-milled titanium abutments. After the units were cemented, 5 levels of interproximal contact tightness were evaluated: open, ideal (8 microm shim stock drags without tearing), light (ideal +10 microm), medium (ideal + 50 microm), and heavy (ideal + 90 microm). For splinted restorations, five 3-unit fixed partial dentures were fabricated, internally adjusted with silicone disclosing material, and cemented to the model. Changes in stress distribution under simulated non-loaded and loaded conditions (6.8 kg) were analyzed with a polariscope. RESULTS In the simulated alveolar structures, non-splinted restorations with heavier interproximal contacts were associated with increased tensile stresses between implants; occlusal loads tended to concentrate around the specific loaded implant. Splinted restorations shared the occlusal loads and distributed the stresses more evenly between the implants when force was applied. The load-sharing effect was most evident on the center implant but also was seen on the terminal abutments of the splinted restorations. CONCLUSION The results of this in vitro study suggest that excessive contact tightness between individual crowns can lead to a non-passive situation. In this experiment, splinted restorations exhibited better load sharing than non-splinted restorations.
Simulation and Optimization of the Multi-Stage Reconnection Electromagnetic Launch

The reconnection electromagnetic launcher utilizes the interaction between the projectile eddy current and the coil magnetic field to accelerate the projectile. A reconnection launch experimental system using the box-shaped helical coils and the flat-plate projectile has been fabricated. Capacitor banks are used as the power supplies. The inductance gradient curve-fitting is performed on the basis of the measured data from the launch apparatus. Based on the circuit equation and the motion equation of the reconnection electromagnetic launch, the numerical simulation model of the projectile motion is established. The simulations show that the launch efficiency decreases when the projectile velocity increases in the multi-stage launch if every stage is kept with the same parameters. To solve the problem, an optimization for the multi-stage launch is presented. The oscillating cycle of the circuit current in each stage is determined according to the projectile velocity, from which the capacitance of the capacitor bank is determined further. Combined with the use of triggered vacuum switches (TVS) as closing switches and owing to the special arc extinguishing performance of the TVS, the projectile velocity can be increased and the launch efficiency can be improved greatly.
Abnormalities of the photoreceptor-bipolar cell synapse in a substrain of C57BL/10 mice.

PURPOSE A preferential loss of ERG b-wave was detected in a substrain of C57BL/10 mice. Electroretinographic and histologic techniques were used to investigate this hitherto unknown retinopathy. METHODS ERGs were obtained from normal and affected C57BL/10. C57BL/6 mice served also as controls. a-Wave and c-wave analyses were performed. Microscopic investigations were done at two different ages. RESULTS In the scotopic ERG, a severe reduction of the b-wave amplitude could be observed, whereas the a-wave was only moderately attenuated ("negative ERG"). With age, the a-wave amplitude further decreased, but the rate of reduction was comparable to normals. Oscillatory potentials were severely altered, and the photopic ERG was absent. The ERG c-wave was comparable to normal. ERG a-wave analysis also revealed a reduced maximum amplitude, but no significant difference of receptor sensitivity. Light microscopy revealed a thinning of all retinal layers but mostly of the outer plexiform layer. The number of photoreceptor nuclei was reduced by one third. Electron microscopy revealed a profound loss of ribbon-shaped synapses between rod and rod-bipolar cells and severely abnormal ribbons in the case of cones. CONCLUSIONS The so-called negative ERG was associated with alterations in the synaptic layer between rods and rod bipolars. The absent cone ERG may be due to the altered cone-on-bipolar synapses. The overall thinning of the retina as well as the moderately reduced scotopic a-wave amplitude remain unexplained.
Paper-based acetylcholinesterase inhibition assay combining a wet system for organophosphate and carbamate pesticides detection

A dramatic increase in pesticide usage in agriculture highlights the need for on-site monitoring for public health and safety. Here, a paper-based sensor combined with a wet system was developed for the simple and rapid screening of organophosphate (OP) and carbamate (CM) pesticides based on the inhibition of acetylcholinesterase (AChE). The paper-based sensor was designed as a foldable device consisting of a cover and detection sheets pre-prepared with indoxyl acetate and AChE, respectively. The paper-based sensor requires only the incubation of a sample on the test zone for 10 minutes, followed by closing of the foldable sheet to initiate the enzymatic reaction. Importantly, the buffer loading hole was additionally designed on the cover sheet to facilitate the interaction of the coated substrate and the immobilized enzyme. This subsequently facilitates the mixing of indoxyl acetate with AChE, resulting in the improved analytical performance of the sensor. The absence or decrease in blue color produced by the AChE hydrolysis of indoxyl acetate can be observed in the presence of OPs and CMs. Under optimized conditions and using image analysis, the limit of detection (LOD) of carbofuran, dichlorvos, carbaryl, paraoxon, and pirimicarb are 0.003, 0.3, 0.5, 0.6, and 0.6 ppm, respectively. The assay could be applied to determine OP and CM residues in spiked food samples. Visual interpretation of the color signal was clearly observed at the concentration of 5 mg/kg. Furthermore, a self-contained sample pre-concentration approach greatly enhanced the detection sensitivity. The paper-based device developed here is low-cost, requires minimal reagents and is easy to handle. As such, it would be practically useful for pesticide screening by non-professional end-users.