Miracle-dz/UniFAR-FTUs huggingface dataset:
Protecting Motor Neurons from Toxic Insult by Antagonism of Adenosine A2a and Trk Receptors

The death of motor neurons in amyotrophic lateral sclerosis (ALS) is thought to result from the interaction of a variety of factors including excitotoxicity, accumulation of toxic proteins, and abnormal axonal transport. Previously, we found that the susceptibility of motor neurons to excitotoxic insults can be limited by inhibiting signals evoked by brain-derived neurotrophic factor (BDNF) activation of the receptor tyrosine kinase B (TrkB). Here we show that this can be achieved by direct kinase inhibition or by blockade of a transactivation pathway that uses adenosine A2a receptors and src-family kinases (SFKs). Downstream signaling cascades (such as mitogen-activated protein kinase and phosphatidylinositol-3 kinase) are inhibited by these blockers. In addition to protecting motor neurons from excitotoxic insult, these agents also prevent toxicity that follows from the expression of mutant proteins (G85R superoxide dismutase 1; G59S p150glued) that cause familial motor neuron disease. TrkB, adenosine A2a receptors, and SFKs associate into complexes in lipid raft and nonlipid raft membranes and the signaling from lipids rafts may be particularly important because their disruption by cholesterol depletion blocks the ability of BDNF to render motor neurons vulnerable to insult. The neuroprotective versatility of Trk antagonism suggests that it may have broad utility in the treatment of ALS patients.
The Effects of Crystalloid and Colloid Preload on Cardiac Output in the Parturient Undergoing Planned Cesarean Delivery Under Spinal Anesthesia: A Randomized Trial

BACKGROUND: Hypotension after spinal anesthesia for cesarean delivery remains a major clinical problem. Fluid preloading regimens together with vasopressors have been used to reduce its incidence. Previous studies have used noninvasive arterial blood pressure measurement and vasopressor requirements to evaluate the effect of preload. We used a suprasternal Doppler flow technique to measure maternal cardiac output (CO) and corrected flow time (FTc, a measure of intravascular volume) before and after spinal anesthesia after 3 fluid preload regimens. We hypothesized that colloid solutions, compared with crystalloid, would produce the largest increase in CO and have the lowest incidence of hypotension. METHODS: Sixty healthy term women scheduled for planned cesarean delivery under spinal anesthesia were recruited for this randomized, double-blind study. Baseline heart rate, systolic blood pressure (SBP), CO, and FTc were recorded in the left lateral tilt position. Patients were randomized to receive 1 of 3 fluid preload regimens given over 15 min: 1.5 L crystalloid (Hartman's solution), 0.5 L of 6% w/v hydroxyethyl starch (HES) solution (HES 0.5), or 1 L of 6% w/v HES solution (HES 1.0). Further measurements were made after fluid loading every 5 min for 30 min. After 30 min, spinal anesthesia was induced with hyperbaric bupivacaine 12.5 mg with fentanyl 15 μg and recordings were continued every 5 min for 20 min or until surgery started. The primary outcome, CO, was compared among groups. The incidence of hypotension (defined as a 20% reduction in SBP from the baseline), ephedrine use, and umbilical cord blood gases were also compared. RESULTS: Patient characteristics, heart rate, SBP, and cord gases were similar among groups. Although CO and FTc increased after preload in all groups (P < 0.005), this was only maintained with HES 1.0 after spinal anesthesia (P < 0.005). There were no differences among groups in the incidence of hypotension (70% vs 35% vs 65% for Hartman's solution, HES 0.5, and HES 1.0, respectively; P = 0.069) or mean ephedrine dose (10.4 vs 5.7 vs 9.7 mg; P = 0.26). CONCLUSION Despite CO and FTc increases after fluid preload, particularly with HES 1.0 L, hypotension still occurred. The data suggest that CO increases after these preload regimens cannot compensate for reductions in arterial blood pressure after spinal anesthesia.
Automatic Analysis of Cricket And Soccer Broadcast Videos

In the past recent years, there has been a growing need to understand the semantics in sports games. Use of technology in analyzing player movements and understanding the action on a sports field has been growing in the past few years. Most of the systems today make use of certain tracking devices worn by players or markers with sensors placed around the play area. These trackers or markers are electronic devices that communicate with the cameras or cameramen. Other technologies such as the goal line technology popularly used in soccer helps game referees to make accurate decisions that are often misjudged by mere human perception. The primary challenges in these techniques is to make it cost effective and ease of installation and use. It is not convenient to setup markers and sensors around the playing field or to force players to wear certain recording or communication devices without affecting their natural style of playing. Placing a sensor in the game ball also poses a tricky problem of not altering the physical properties of the ball. Sports recorders and broadcasters are now looking for simple and yet effective solutions to get semantic information from a sports game. The big question here is Can we get sufficient important data only from a video capture just as a human would without relying on external aids of markers and sensors? With advances in various computer vision algorithms and techniques the goal for the future is to analyze everything from captured video. This kind of solution is obviously more attractive to broadcasting and game recording companies as they dont need to setup extra equipment, or influence the authorities to change the match ball or players outfits. We propose a set of algorithms that does the task of automatic analysis for broadcast videos for the sports of Cricket and Soccer. Using our approach we can automatically detect salient events in Soccer, Temporally align Cricket video with corresponding text commentaries, Localize/Register a soccer image and others. We also compare our algorithms with other state of the art approaches extensively on different datasets for a variety of tasks.
EFFECT OF Co-SUBSTITUTION OF ( Bi , Mn ) IONS ON STRUCTURAL , MAGNETIC AND DIELECTRIC PROPERTIES OF ( DyFeO 3 ) DYSPROSIUM ORTHOFERRITE

Nanostructures of Dy1-xBixFe1-yMnyO3 system (x,y) = ( 0.00, 0.10, 0.20, 0.30 and 0.40) were synthesized usingsynchronized double ions substitution by micro-emulsion method at room temperature. Structural, magnetic as well as dielectric properties were investigated by X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, vibrating sample magnetometer (VSM) and Dielectric measurements respectively. XRD analysis confirms at all samples have orthorhombic structure, and successful substitution of (Bi,Mn) ions into DyFeO3 crystal structure. The physical parameters were measured from XRD data and found the crystallite size was decreased from (54.9 36.6nm)by increasing (x, y) = (Bi, Mn) content. FT-IR analysis showed functional groups and chemical interactions of the sample (x,y) = (0.20) corresponding to the Mn-O, Fe-O and Bi-O bands. The magnetic measurements of all the synthesized samples exhibit paramagnetic behaviour at room temperature. Finally the dielectric parameters results such as the dielectric constant, imaginary dielectric constant and tangent loss were studied at different applied frequencies.
MICROSTRUCTURAL DEVELOPMENT DURING IRRADIATION OF AFIP-1 FUEL PLATES

The growth of fuel/matrix interaction layers during irradiation of U-Mo dispersion fuels can be affected by many different variables related to the characteristics of the as-fabricated fuel plate (e.g., the amount of Si in the fuel meat matrix) and the parameters used during the reactor test (e.g., the irradiation temperature, power density, fission density, fission rate). Recently, the microstructures of irradiated full-size AFIP-1 fuel plates have been characterized along with as-fabricated AFIP-1 archives, allowing for the comparison of microstructures before and after irradiation. This paper reports the changes in microstructure that occurred during irradiation of AFIP-1 fuel plates with Al-2Si and AA4043 matrix.
Regression Shrinkage and Selection via the Lasso

SUMMARY We propose a new method for estimation in linear models. The 'lasso' minimizes the residual sum of squares subject to the sum of the absolute value of the coefficients being less than a constant. Because of the nature of this constraint it tends to produce some coefficients that are exactly 0 and hence gives interpretable models. Our simulation studies suggest that the lasso enjoys some of the favourable properties of both subset selection and ridge regression. It produces interpretable models like subset selection and exhibits the stability of ridge regression. There is also an interesting relationship with recent work in adaptive function estimation by Donoho and Johnstone. The lasso idea is quite general and can be applied in a variety of statistical models: extensions to generalized regression models and tree-based models are briefly described.
Approaching the Black Hole by Numerical Simulations

Black holes represent extreme conditions of physical laws. Predicted about a century ago, they are now accepted as astrophysical reality by most of the scientific community. Only recently has more direct evidence of their existence been found—the detection of gravitational waves from black hole mergers and of the shadow of a supermassive black hole in the center of a galaxy. Astrophysical black holes are typically embedded in an active environment which is affected by the strong gravity. When the environmental material emits radiation, this radiation may carry imprints of the black hole that is hosting the radiation source. In order to understand the physical processes that take place in the close neighborhood of astrophysical black holes, numerical methods and simulations play an essential role. This is simply because the dynamical evolution and the radiative interaction are far too complex in order to allow for an analytic solution of the physical equations. A huge progress has been made over the last decade(s) in the numerical code development, as well as in the computer power that is needed to run these codes. This review tries to summarize the basic questions and methods that are involved in the undertaking of investigating the astrophysics of black holes by numerical means. It is intended for a non-expert audience interested in an overview over this broad field. The review comes along without equations and thus without a detailed expert discussion of the underlying physical processes or numerical specifics. Instead, it intends to illustrate the richness of the field and to motivate further reading. The review puts some emphasis on magneto-hydrodynamic simulations but also touches radiation transfer and merger simulations, in particular pointing out differences in these approaches.
Influence of the properties of corundum aggregates on the strength and slag resistance of refractory castables

Three refractory castables containing corundum aggregates with different porosities, average pore size and strength and the same matrices were fabricated. The effects of the properties of corundum aggregates on the strength and slag resistance of refractory castables were investigated through an X-ray diffractometer (XRD), scanning electron microscopy (SEM), mercury porosimetry measurements, etc. It was found that the properties of corundum aggregates have an important effect on the bulk density, porosity, compressive strength and slag resistance of refractory castables, but have little effect on the flexural strength of refractory castables. Compared with a castable containing white fused corundum aggregate (with a porosity of 4.2% and a bulk density of 3.62 g/cm), the castable containing a porous corundum aggregate (with a porosity of 42.0% and a bulk density of 2.29 g/cm) has a higher porosity of 35.7%, a lower bulk density of 2.44 g/cm, a lower but sufficient compressive strength (80.4 MPa) and a lower slag resistance, but has a similar flexural strength (20.3 MPa), and then has a potential application for a non-slag working lining of a ladle to decrease the consumption of energy and Al2O3 material.
18 th International Conference on Composite Materials PREDICTING DAMAGE ACCUMULATION IN GLASS FIBER REINFORCED PLASTICS THROUGH CUMULATIVE DAMAGE MODELS

Three cumulative damage models are examined for the case of cyclic loading of S2 and E glass fiber/epoxy composites. The Palmgren-Miner, Broutman-Sahu and Hashin-Rotem models are compared to determine which of the three gives a more accurate estimation of the fatigue life of the two composite materials tested. In addition, comparison of the fatigue life of the materials shows the superiority of S2 over E glass fiber/epoxy.
Care-Seeking Pattern among Persons with Depression and Anxiety: A Population-Based Study in Sweden

Background. In primary care, a vast majority of patients affected with depression and anxiety present with somatic symptoms. Detection rate of psychiatric symptoms is low, and knowledge of factors influencing care seeking in persons affected by depressive and anxiety disorders on a population level is limited. Objective. This study aims to describe if persons, affected by depression and anxiety disorders, seek care and which type of care they seek as well as factors associated with care seeking. Method. Data derives from a longitudinal population-based study of mental health conducted in the Stockholm County in 1998–2010 and the present study includes 8387 subjects. Definitions of anxiety and depressive disorders were made according to DSM-IV criteria, including research criteria, using validated diagnostic scales. 2026 persons (24%) fulfilled the criteria for any depressive or anxiety disorder. Results. Forty-seven percent of those affected by depression and/or anxiety had been seeking care for psychological symptoms within the last year. A major finding was that seeking care for psychological symptoms was associated with having treatment for somatic problems. Conclusions. As a general practitioner, it is of great importance to increase awareness of mild mental illness, especially among groups that might be less expected to be affected.
Reevaluation of Gray and White Matter Injury after Spinal Cord Ischemia in Rabbits

Background:Although gray matter injury has been well characterized, the available data on white matter injury after spinal cord ischemia (SCI) in rabbits are limited. The current study was conducted to investigate the evolution of ischemia induced injury to gray and white matter and to correlate this damage to hind-limb motor function in rabbits subjected to SCI. Methods:Thirty-eight rabbits were randomly assigned to 24-h, 4-day, or 14-day reperfusion groups or a sham group (n = 9 or 10 per group). SCI was induced by occlusion of the infrarenal aorta for 16 min. Hind-limb motor function was assessed using the Tarlov scale (0 = paraplegia, 4 = normal). The gray matter damage was assessed on the basis of the number of normal neurons in the anterior spinal cord. White matter damage was assessed on the basis of the extent of vacuolation and accumulation of amyloid precursor protein immunoreactivity. Results:Tarlov scores gradually decreased and reached a nadir 14 days after reperfusion. There were no significant differences in the number of normal neurons among the 24-h, 4-day, and 14-day groups. The extent of vacuolation, expressed as a percent of total white matter area, was significantly greater in the 4-day and 14-day groups in comparison with the sham group. By contrast, there was no difference in vacuolation between the sham and 24-h groups. Amyloid precursor protein immunoreactivity was greater in the 4-day and 14-day groups. Conclusion:The results in the current study show that SCI induced white matter injury as well as gray matter injury in a rabbit model of SCI. The time course for 14 days after reperfusion may differ among the gray and white matter damages and hind-limb motor function in rabbits subjected to SCI.
Node-oriented Internet Protocol: A novel concept for enhancement of mobility and multi-homing in Future Internet

Mobility and multi-homing are closely related and mainly issues of the used IP addressing scheme. Novel addressing schemes that separate node identification and location are promising concepts to tackle the named issues. However, current approaches that make use of the address separation concept offer, among others, insufficient capabilities to select one or multiple network interfaces for a certain communication process, e.g. to enable load balancing. Therefore, we propose a novel approach called Node-oriented Internet Protocol (NIP). NIP adapts the address separation concept, introduces a novel three-tuple addressing scheme that adds an interface ID and enables network nodes to select sets of network interfaces to be used for communication sessions. Our work includes basic concepts for mapping system, schemes for packet forwarding, mechanisms for mobility and multi-homing support and strategies to ensure backwards compatibility. Building on that, the NIP concept enhances multi-homing and mobility capabilites with new functionalities in comparison to known approaches, especially referred to interface selection and bandwidth aggregation.
An evaluation of lucerne for persistence under grazing in New Zealand

The on-farm use of lucerne (Medicago sativa) for grazing and conserved feed has increased in New Zealand over recent years, with new cultivars coming onto the market, including more winter-active ones. The extent to which the winter active types contribute to annual feed production, and the relationship to critical traits like persistence, has not been systematically tested. Two concurrent trials over a 4-year period were used to evaluate a range of lucerne cultivars and elite experimental populations ranging in dormancy from 2 (highly dormant) to 10 (non-dormant) under contrasting grazing regimes near Lincoln, New Zealand. More winter-active cultivars in the higher fall dormancy (FD) classes had similar growth to lower FD classes in all seasons except autumn, where they exhibited 18% greater yield than the lowest FD entry. However, these higher FD populations do not persist as well under heavy grazing, with a reduction in ground cover of up to 90% after four years, compared with only a 25% loss in lower FD classes. There was a negative correlation between FD and persistence measured as plant survival over 4 years (R2=0.73). However, one high FD entry showed increased survival under grazing, suggesting there is scope for selection of types with improved cool season growth and grazing tolerance. The concurrent lucerne trial subjected to a low-frequency grazing/ cutting regime showed faster recovery from defoliation than the adjacent hard grazed regime, suggesting stored underground reserves were more available for regrowth. We concluded that lucerne cultivars with FD ratings in the 3 to 5 range are most suitable for yield and persistence under grazing in these conditions. There is also scope for breeding to improve plant survival and dry matter yield within FD class.
Statistical analysis of early marriage among women in Ethiopia by using multilevel logistic regression

Early marriage is still widely practiced in many parts of the world mainly in Latin America, the Caribbean, Southern Asia and countries of Africa. Ethiopia has one of the highest rates of early marriage in Sub-Saharan Africa. The main objective of this study was to identify determinants of early marriage among women in Ethiopians and to examine variations in early marriage between and within regions of Ethiopia. The study is made based on the Ethiopian Demographic and Health Survey 2011 data that has two stages sampling hierarchical structure, collected for 9262 married women nested within eleven regions with age 15-49 years. Descriptive statistics and multilevel logistic regression model analysis were used to examine the prevalence and identify determinants of early marriage. The results of descriptive statistics shows that Out of the 9,262 married women, 3320(35.8%) of marriages occur 18 years and above while 5942 (64.2%) of these women married early (under 18 years) at the time of the survey.
Cash Holdings, Corporate Governance and Financial Constraints

We examine the relation between cash holdings, quality of governance and financial constraints. We find that firms with strong shareholder rights hold more cash, contrary to the predictions of agency theory. This result is partly due to the positive correlation that exists between governance quality measures and the degree of financial constraint faced by the firm. We show that governance quality has no impact on cash holdings by financially unconstrained firms. It does, however, have a positive impact on the cash holdings of certain financially constrained firms, particularly family firms. Anti-takeover provisions give these firms extra flexibility, enabling them to issue shares without the founding family losing control, and provide an alternative to high cash holdings.
Endothelial Cell mTOR Complex-2 Regulates Sprouting Angiogenesis

Tumor neovascularization is targeted by inhibition of vascular endothelial growth factor (VEGF) or the receptor to prevent tumor growth, but drug resistance to angiogenesis inhibition limits clinical efficacy. Inhibition of the phosphoinositide 3 kinase pathway intermediate, mammalian target of rapamycin (mTOR), also inhibits tumor growth and may prevent escape from VEGF receptor inhibitors. mTOR is assembled into two separate multi-molecular complexes, mTORC1 and mTORC2. The direct effect of mTORC2 inhibition on the endothelium and tumor angiogenesis is poorly defined. We used pharmacological inhibitors and RNA interference to determine the function of mTORC2 versus Akt1 and mTORC1 in human endothelial cells (EC). Angiogenic sprouting, EC migration, cytoskeleton re-organization, and signaling events regulating matrix adhesion were studied. Sustained inactivation of mTORC1 activity up-regulated mTORC2-dependent Akt1 activation. In turn, ECs exposed to mTORC1-inhibition were resistant to apoptosis and hyper-responsive to renal cell carcinoma (RCC)-stimulated angiogenesis after relief of the inhibition. Conversely, mTORC1/2 dual inhibition or selective mTORC2 inactivation inhibited angiogenesis in response to RCC cells and VEGF. mTORC2-inactivation decreased EC migration more than Akt1- or mTORC1-inactivation. Mechanistically, mTORC2 inactivation robustly suppressed VEGF-stimulated EC actin polymerization, and inhibited focal adhesion formation and activation of focal adhesion kinase, independent of Akt1. Endothelial mTORC2 regulates angiogenesis, in part by regulation of EC focal adhesion kinase activity, matrix adhesion, and cytoskeletal remodeling, independent of Akt/mTORC1.
THE COSMIC DECLINE IN THE H2/H i RATIO IN GALAXIES

We use a pressure-based model for splitting cold hydrogen into its atomic (H i) and molecular (H2) components to tackle the co-evolution of H i, H2, and star formation rates (SFR) in ∼3 × 107 simulated galaxies in the Millennium simulation. The main prediction is that galaxies contained similar amounts of H i at redshift z ≈ 1–5 than today, but substantially more H2, in quantitative agreement with the strong molecular line emission already detected in a few high-redshift galaxies and approximately consistent with inferences from studies of the damped Lyman-α absorbers seen in the spectra of quasars. The cosmic H2/H i ratio is predicted to evolve monotonically as . This decline of the H2/H i ratio as a function of cosmic time is driven by the growth of galactic disks and the progressive reduction of the mean cold gas pressure. Finally, a comparison between the evolutions of H i, H2, and SFRs reveals two distinct cosmic epochs of star formation: an early epoch (z ≳ 3), driven by the evolution of , and a late epoch (z ≲ 3), driven by the evolution of .