Miracle-dz/UniFAR-FTUs huggingface dataset:
Measurement of Lubricating Oil Film Thickness between Piston Ring -liner Interface in an Engine Simulator

The interface between the piston rings and cylinder liner play an important role in total frictional losses and mechanical wear of internal combustion engine and is increasingly coming under scrutiny as legislated particulate emission standards are getting more and more stringent. The capacitance method is used for measurement of minimum oil film thickness between piston ring and liner interface. Measurement of capacitance formed between the piston ring and a probe mounted flush in the liner provides an accurate means of determining the oil film thickness provided that the region between the probe and liner is flooded with oil and dielectric constant of the oil is known. This paper presents detailed design and measurement of lubricating oil film thickness using capacitive micro sensor in a nonfiring engine simulator. Lubricating oil film thickness was found to vary between 0. 2μm to 8μm in the non firing engine simulator. At a particular position, lubricating oil film thickness varies significantly in upward and downward stroke of the engine due to reversal in direction of piston tilt in the two directions of motion.
Genome-Wide Association Scan Identifies a Risk Locus for Preeclampsia on 2q14, Near the Inhibin, Beta B Gene

Elucidating the genetic architecture of preeclampsia is a major goal in obstetric medicine. We have performed a genome-wide association study (GWAS) for preeclampsia in unrelated Australian individuals of Caucasian ancestry using the Illumina OmniExpress-12 BeadChip to successfully genotype 648,175 SNPs in 538 preeclampsia cases and 540 normal pregnancy controls. Two SNP associations (rs7579169, p = 3.58×10−7, OR = 1.57; rs12711941, p = 4.26×10−7, OR = 1.56) satisfied our genome-wide significance threshold (modified Bonferroni p<5.11×10−7). These SNPs reside in an intergenic region less than 15 kb downstream from the 3′ terminus of the Inhibin, beta B (INHBB) gene on 2q14.2. They are in linkage disequilibrium (LD) with each other (r2 = 0.92), but not (r2<0.80) with any other genotyped SNP ±250 kb. DNA re-sequencing in and around the INHBB structural gene identified an additional 25 variants. Of the 21 variants that we successfully genotyped back in the case-control cohort the most significant association observed was for a third intergenic SNP (rs7576192, p = 1.48×10−7, OR = 1.59) in strong LD with the two significant GWAS SNPs (r2>0.92). We attempted to provide evidence of a putative regulatory role for these SNPs using bioinformatic analyses and found that they all reside within regions of low sequence conservation and/or low complexity, suggesting functional importance is low. We also explored the mRNA expression in decidua of genes ±500 kb of INHBB and found a nominally significant correlation between a transcript encoded by the EPB41L5 gene, ∼250 kb centromeric to INHBB, and preeclampsia (p = 0.03). We were unable to replicate the associations shown by the significant GWAS SNPs in case-control cohorts from Norway and Finland, leading us to conclude that it is more likely that these SNPs are in LD with as yet unidentified causal variant(s).
Constipation Risk in Patients Undergoing Abdominal Surgery

Background: Problems regarding bowel elimination are quite common in patients undergoing abdominal surgery. Objectives: To determine constipation risk before the surgery, bowel elimination during postoperative period, and the factors affecting bowel elimination. Patients and Methods: This is a cross-sectional study. It was conducted in a general surgery ward of a university hospital in Zonguldak, Turkey between January 2013 and May 2013. A total of 107 patients were included in the study, who were selected by convenience sampling. Constipation Risk Assessment Scale (CRAS), patient information form, medical and nursing records were used in the study. Results: The mean age of the patients was found to be 55.97 ± 15.74 (year). Most of the patients have undergone colon (37.4%) and stomach surgeries (21.5%). Open surgical intervention (83.2%) was performed on almost all patients (96.3%) under general anesthesia. Patients were at moderate risk for constipation with average scores of 11.71 before the surgery. A total of 77 patients (72%) did not have bowel elimination problem during postoperative period. The type of the surgery (P < 0.05), starting time for oral feeding after the surgery (P < 0.05), and mobilization (P < 0.05) were effective on postoperative bowel elimination. Conclusions: There is a risk for constipation after abdominal surgery. Postoperative practices are effective on the risk of constipation.
BAG3 and Hsc70 Interact With Actin Capping Protein CapZ to Maintain Myofibrillar Integrity Under Mechanical Stress

Rationale: A homozygous disruption or genetic mutation of the bag3 gene, a member of the Bcl-2–associated athanogene (BAG) family proteins, causes cardiomyopathy and myofibrillar myopathy that is characterized by myofibril and Z-disc disruption. However, the detailed disease mechanism is not yet fully understood. Objective: bag3−/− mice exhibit differences in the extent of muscle degeneration between muscle groups with muscles experiencing the most usage degenerating at an accelerated rate. Usage-dependent muscle degeneration suggests a role for BAG3 in supporting cytoskeletal connections between the Z-disc and myofibrils under mechanical stress. The mechanism by which myofibrillar structure is maintained under mechanical stress remains unclear. The purpose of the study is to clarify the detailed molecular mechanism of BAG3-mediated muscle maintenance under mechanical stress. Methods and Results: To address the question of whether bag3 gene knockdown induces myofibrillar disorganization caused by mechanical stress, in vitro mechanical stretch experiments using rat neonatal cardiomyocytes and a short hairpin RNA–mediated gene knockdown system of the bag3 gene were performed. As expected, mechanical stretch rapidly disrupts myofibril structures in bag3 knockdown cardiomyocytes. BAG3 regulates the structural stability of F-actin through the actin capping protein, CapZ&bgr;1, by promoting association between Hsc70 and CapZ&bgr;1. BAG3 facilitates the distribution of CapZ&bgr;1 to the proper location, and dysfunction of BAG3 induces CapZ ubiquitin–proteasome–mediated degradation. Inhibition of CapZ&bgr;1 function by overexpressing CapZ&bgr;2 increased myofibril vulnerability and fragmentation under mechanical stress. On the other hand, overexpression of CapZ&bgr;1 inhibits myofibrillar disruption in bag3 knockdown cells under mechanical stress. As a result, heart muscle isolated from bag3−/− mice exhibited myofibrillar degeneration and lost contractile activity after caffeine contraction. Conclusions: These results suggest novel roles for BAG3 and Hsc70 in stabilizing myofibril structure and inhibiting myofibrillar degeneration in response to mechanical stress. These proteins are possible targets for further research to identify therapies for myofibrillar myopathy or other degenerative diseases.
Closed-Form Dynamic Stability Criterion for Elastic–Plastic Structures under Near-Fault Ground Motions

A dynamic stability criterion for elastic-plastic structures under near-fault ground motions is derived in closed-form. A negative post-yield stiffness is treated in order to consider the P-delta effect. The double impulse is used as a substitute of the fling-step near-fault ground motion. Since only the free-vibration appears under such double impulse, the energy approach plays a critical role in the derivation of the closed-form solution of a complicated elastic-plastic response of structures with the P-delta effect. It is remarkable that no iteration is needed in the derivation of the closed-form dynamic stability criterion on the critical elastic-plastic response. It is shown via the closed-form expression that several patterns of unstable behaviors exist depending on the ratio of the input level of the double impulse to the structural strength and on the ratio of the negative post-yield stiffness to the initial elastic stiffness. The validity of the proposed dynamic stability criterion is investigated by the numerical response analysis for structures under double impulses with stable or unstable parameters. Furthermore the reliability of the proposed theory is tested through the comparison with the response analysis to the corresponding one-cycle sinusoidal input as a representative of the fling-step near-fault ground motion. The applicability of the proposed theory to actual recorded pulse-type ground motions is also discussed.
Open Problems in Computer Virus Research

Over a decade of work on the computer virus problem has resulted in a number of useful scientific and technological achievements. The study of biological epidemiology has been extended to help us understand when and why computer viruses spread. Techniques have been developed to help us estimate the safety and effectiveness of anti-virus technology before it is deployed. Technology for dealing with known viruses has been very successful, and is being extended to deal with previously unknown viruses automatically. Yet there are still important research problems, the solution to any of which significantly improve our ability to deal with the virus problems of the near future. The goal of this paper is to encourage clever people to work on these problems. To this end, we examine several open research problems in the area of protection from computer viruses. For each problem, we review the work that has been done to date, and suggest possible approaches. There is clearly enough work, even in the near term, to keep researchers busy for quite a while. There is every reason to believe that, as software technology evolves over the next century or so, there will plenty of important and interesting new problems that must be solved in this field.
Dynamic Positioning System for a Ship on Harbour Manoeuvring with Different Observers. Experimental Results

Abstract In cases when the navigational space of the manoeuvre performed by the ship is severely limited, the procedures making use of the rudder blade, propeller screw, and thrusters are very complicated. Such situations take place when the ship manoeuvres inside the harbour area and in those cases the structure of the control system is very complex. Te article describes the algorithm of multivariable control of ship motion over the water surface, which makes use of the state vector consisting of 6 variables. Tree of them, which are the position coordinates (x, y) measured by the DGPS system and the ship heading y measured by gyro-compass, were obtained experimentally. Te three remaining variables, which are the velocities in surge u, sway v, and yaw r directions, were estimated by Kalman filter, Kalman-Bucy filter and extended Kalman flter, respectively. The control algorithms making use of these observers were examined using the training ship “Blue Lady” which was navigated on the lake Silm in Ilawa/Kamionka in the Ship Handling Research and Training Centre owned by the Foundation for Safety of Navigation and Environment Protection. Te experimental results obtained using control systems with three observers were finally compared between each other.
p53 and bcl‐2 expression do not correlate with prognosis in primary cutaneous large T‐cell lymphomas

Overexpression of p53 protein in cutaneous T‐cell lymphoma (CTCL) has been reported in primary cutaneous large T‐cell lymphomas (PCLTCL) and has been associated with tumor progression and transformation in mycosis fungoides. However, the prognostic significance of p53 expression has not been studied thus far. In the present study we investigated the expression of p53 as well as bcl‐2 protein in 27 PCLTCL, including 19 CD30‐positive and 8 CD30‐negative lymphomas, retrieved from the registry of the Dutch Cutaneous Lymphoma Working Group.
The aiding of a low-cost strapdown inertial measurement unit using vehicle model constraints for land vehicle applications

This paper presents a new method for improving the accuracy of inertial measurement units (IMUs) mounted on land vehicles. The algorithm exploits nonholonomic constraints that govern the motion of a vehicle on a surface to obtain velocity observation measurements which aid in the estimation of the alignment of the IMU as well as the forward velocity of the vehicle. It is shown that this can be achieved without any external sensing provided that certain observability conditions are met. A theoretical analysis is provided together with a comparison of experimental results between a nonlinear implementation of the algorithm and an IMU/GPS navigation system. This comparison demonstrates the effectiveness of the algorithm. The real time implementation is also addressed through a multiple observation inertial aiding algorithm based on the information filter. The results show that the use of these constraints and vehicle speed guarantees the observability of the velocity and the attitude of the inertial unit, and hence bounds the errors associated with these states. The strategies proposed provides a tighter navigation loop which can sustain outages of GPS for a greater amount of time as compared to when the inertial unit is used with standard integration algorithms.
Altered Calcium Channel Currents in Purkinje Cells of the Neurological Mutant Mouse leaner

Mutations of the α1A calcium channel subunit have been shown to cause such human neurological diseases as familial hemiplegic migraine, episodic ataxia-2, and spinocerebellar ataxia 6 and also to cause the murine neurological phenotypes oftottering and leaner. Theleaner phenotype is recessive and characterized by ataxia with cortical spike and wave discharges (similar to absence epilepsy in humans) and a gradual degeneration of cerebellar Purkinje and granule cells. The mutation responsible is a single-base substitution that produces truncation of the normal open reading frame beyond repeat IV and expression of a novel C-terminal sequence. Here, we have used whole-cell recordings to determine whether theleaner mutation alters calcium channel currents in cerebellar Purkinje cells, both because these cells are profoundly affected in leaner mice and because they normally express high levels of α1A. In Purkinje cells from normal mice, 82% of the whole-cell current was blocked by 100 nmω-agatoxin-IVA. In Purkinje cells from homozygousleaner mice, this ω-agatoxin-IVA-sensitive current was 65% smaller than in control cells. Although attenuated, the ω-agatoxin-IVA-sensitive current in homozygous leanercells had properties indistinguishable from that of normal Purkinje neurons. Additionally, the ω-agatoxin-IVA-insensitive current was unaffected in homozygous leaner mice. Thus, theleaner mutation selectively reduces P-type currents in Purkinje cells, and the α1A subunit and P-type current appear to be essential for normal cerebellar function.
Mechanisms for the Inhibition of DNA Methyltransferases by Tea Catechins and Bioflavonoids

In the present investigation, we studied the modulating effects of several tea catechins and bioflavonoids on DNA methylation catalyzed by prokaryotic SssI DNA methyltransferase (DNMT) and human DNMT1. We found that each of the tea polyphenols [catechin, epicatechin, and (–)-epigallocatechin-3-O-gallate (EGCG)] and bioflavonoids (quercetin, fisetin, and myricetin) inhibited SssI DNMT- and DNMT1-mediated DNA methylation in a concentration-dependent manner. The IC50 values for catechin, epicatechin, and various flavonoids ranged from 1.0 to 8.4 μM, but EGCG was a more potent inhibitor, with IC50 values ranging from 0.21 to 0.47 μM. When epicatechin was used as a model inhibitor, kinetic analyses showed that this catechol-containing dietary polyphenol inhibited enzymatic DNA methylation in vitro largely by increasing the formation of S-adenosyl-l-homocysteine (a potent noncompetitive inhibitor of DNMTs) during the catechol-O-methyltransferase-mediated O-methylation of this dietary catechol. In comparison, the strong inhibitory effect of EGCG on DNMT-mediated DNA methylation was independent of its own methylation and was largely due to its direct inhibition of the DNMTs. This inhibition is strongly enhanced by Mg2+. Computational modeling studies showed that the gallic acid moiety of EGCG plays a crucial role in its high-affinity, direct inhibitory interaction with the catalytic site of the human DNMT1, and its binding with the enzyme is stabilized by Mg2+. The modeling data on the precise molecular mode of EGCG's inhibitory interaction with human DNMT1 agrees perfectly with our experimental finding.
Different Types of X-Ray Bursts from GRS 1915+105 and Their Origin

We report X-ray observations of the Galactic X-ray transient source GRS 1915+105 with the pointed proportional counters of the Indian X-ray Astronomy Experiment (IXAE) onboard the Indian satellite IRS-P3, which show remarkable richness in temporal variability. The observations were carried out on 1997 June 12-29 and August 7-10, in the energy range of 2-18 keV and revealed the presence of very intense X-ray bursts. All the observed bursts have a slow exponential rise, a sharp linear decay, and broadly can be put in two classes: irregular and quasi-regular bursts in one class, and regular bursts in the other. The regular bursts are found to have two distinct timescales and to persist over extended durations. There is a strong correlation between the preceding quiescent time and the burst duration for the quasi-regular and irregular bursts. No such correlation is found for the regular bursts. The ratio of average flux during the burst time to the average flux during the quiescent phase is high and variable for the quasi-regular and irregular bursts, while it is low and constant for the regular bursts. We present a comprehensive picture of the various types of bursts observed in GRS 1915+105 in the light of the recent theories of advective accretion disks. We suggest that the peculiar bursts that we have seen are characteristic of the change of state of the source. The source can switch back and forth between the low-hard state and the high-soft state near critical accretion rates in a very short timescale, giving rise to the irregular and quasi-regular bursts. The fast timescale for the transition of the state is explained by invoking the appearance and disappearance of the advective disk in its viscous timescale. The periodicity of the regular bursts is explained by matching the viscous timescale with the cooling timescale of the postshock region. A test of the model is presented using the publicly available 13-60 keV RXTE/PCA data for irregular and regular bursts concurrent with our observations. It is found that the 13-60 keV flux relative to the 2-13 keV flux shows clear evidence for state change between the quiescent phase and the burst phase. The value of this ratio during burst is consistent with the values observed during the high-soft state seen on 1997 August 19, while its value during quiescent phase is consistent with the values observed during the low-hard state seen on 1997 May 8.
Variations in the Thickness and Composition of the Skin of the Giraffe

This study examined the skin of two 1‐ to 2‐year‐old male giraffes and one adult male, determining skin thickness and histological structure with reference to it functioning as a component of the features required for the maintenance of blood pressure, dermal armor, or thermoregulation. It has been argued that a tight skin surrounding the extremities of the giraffe aids in the movement of fluid against gravity, hence preventing pooling of blood and tissue fluid (edema), but the skin has also been implicated in the thermoregulatory capacities and defensive anatomy of many mammalian species. In one of the younger giraffes, one‐half of the skin was analyzed from which close to 170 sites were measured. In the other young and adult giraffes, spot tests to confirm the pattern observed in the fully analyzed individual were undertaken. It was discovered that the skin varied in thickness across the entire body and within regions of the body. Histological evaluation revealed that the skin was mostly collagenous, although interesting patterns of elastic fiber densities were also apparent. The skin in the neck and legs exhibited a morphology that may assist in cardiovascular regulation of blood flow to and from the head and legs, and the skin of the trunk and anterior neck has the possibility of functioning in a protective role. The analyses performed could not add any new data regarding the thermoregulatory role already described for giraffe skin. Anat Rec 293:1615–1627, 2010. © 2010 Wiley‐Liss, Inc.
Multilevel Modelling of the Geographical Distributions of Diseases

Multilevel modelling is used on problems arising from the analysis of spatially distributed health data. We use three applications to demonstrate the use of multilevel modelling in this area. The first concerns small area all‐cause mortality rates from Glasgow where spatial autocorrelation between residuals is examined. The second analysis is of prostate cancer cases in Scottish counties where we use a range of models to examine whether the incidence is higher in more rural areas. The third develops a multiple‐cause model in which deaths from cancer and cardiovascular disease in Glasgow are examined simultaneously in a spatial model. We discuss some of the issues surrounding the use of complex spatial models and the potential for future developments.
Spotting laughter in natural multiparty conversations: A comparison of automatic online and offline approaches using audiovisual data

It is essential for the advancement of human-centered multimodal interfaces to be able to infer the current user's state or communication state. In order to enable a system to do that, the recognition and interpretation of multimodal social signals (i.e., paralinguistic and nonverbal behavior) in real-time applications is required. Since we believe that laughs are one of the most important and widely understood social nonverbal signals indicating affect and discourse quality, we focus in this work on the detection of laughter in natural multiparty discourses. The conversations are recorded in a natural environment without any specific constraint on the discourses using unobtrusive recording devices. This setup ensures natural and unbiased behavior, which is one of the main foci of this work. To compare results of methods, namely Gaussian Mixture Model (GMM) supervectors as input to a Support Vector Machine (SVM), so-called Echo State Networks (ESN), and a Hidden Markov Model (HMM) approach, are utilized in online and offline detection experiments. The SVM approach proves very accurate in the offline classification task, but is outperformed by the ESN and HMM approach in the online detection (F1 scores: GMM SVM 0.45, ESN 0.63, HMM 0.72). Further, we were able to utilize the proposed HMM approach in a cross-corpus experiment without any retraining with respectable generalization capability (F1score: 0.49). The results and possible reasons for these outcomes are shown and discussed in the article. The proposed methods may be directly utilized in practical tasks such as the labeling or the online detection of laughter in conversational data and affect-aware applications.