Miracle-dz/UniFAR-FTUs huggingface dataset:
Investigating user resistance to information systems implementation: a status quo bias perspective

User resistance to information systems implementation has been identified as a salient reason for the failure of new systems and hence needs to be understood and managed. While previous research has explored the reasons for user resistance, there are gaps in our understanding of how users evaluate change related to a new information system and decide to resist it. In particular, missing in the explanation of user decision making is the concept of status quo bias, that is, that user resistance can be due to the bias or preference to stay with the current situation. Motivated thus, this study develops a model to explain user resistance prior to a new IS implementation by integrating the technology acceptance and resistance literatures with the status quo bias perspective. The results of testing the model in the context of a new enterprise system implementation indicate the central role of switching costs in increasing user resistance. Further, switching costs also mediate the relationship between other antecedents (colleague opinion and self-efficacy for change) and user resistance. Additionally, perceived value and organizational support for change are found to reduce user resistance. This research advances the theoretical understanding of user acceptance and resistance prior to a new IS implementation and offers organizations suggestions for managing such resistance.
The expression and functional evidence for voltage-dependent potassium channel Kv1.3 in lymphocytes during aging in spontaneously hypertensive rats.

AIMS Our previous studies showed that expression and functional profile of voltage-dependent potassium channels Kv1.3 were increased in lymphocytes of spontaneously hypertensive rats (SHR) compared to normotensive rats, suggesting a crucial role for lymphocyte Kv1.3 in the development of hypertension. Here, we further investigated whether the expression and functional profile of Kv1.3 was related to increased blood pressure in SHR with age of 4, 8, 16 and 24 wk. METHODS Systolic blood pressure was measured through pressure device around the tail. mRNA and protein expression were assessed by real-time PCR and western blot in lymphocytes of SHR. Current density of Kv channels in lymphocytes was measured by patch-clamp. RESULTS Systolic blood pressure was elevated in an age-dependent manner (ANOVA P < 0.05). mRNA and protein level of Kv1.3 were significantly increased in an age-dependent manner in lymphocyte of SHR (ANOVA P < 0.05). Moreover, the current density of Kv was dramatically enhanced in an age-dependent manner (ANOVA P < 0.05). CONCLUSION The systolic blood pressure positively correlated with expression as well as current density of potassium channels in lymphocytes of SHR at age of 8, 16 and 24 wk. In conclusion, Kv1.3 channels were upregulated in an age-dependent manner in SHR and correlates with systolic blood pressure during aging. The present study implies that Kv1.3 blockers may be applied as a therapeutic treatment for the development of hypertension during aging.
Structure and Assembly of Intracellular Mature Vaccinia Virus: Isolated-Particle Analysis

ABSTRACT In a series of papers, we have provided evidence that during its assembly vaccinia virus is enveloped by a membrane cisterna that originates from a specialized, virally modified, smooth-membraned domain of the endoplasmic reticulum (ER). Recently, however, Hollinshead et al. (M. Hollinshead, A. Vanderplasschen, G. I. Smith, and D. J. Vaux, J. Virol. 73:1503–1517, 1999) argued against this hypothesis, based on their interpretations of thin-sectioned material. The present article is the first in a series of papers that describe a comprehensive electron microscopy (EM) analysis of the vaccinia Intracellular Mature Virus (IMV) and the process of its assembly in HeLa cells. In this first study, we analyzed the IMV by on-grid staining, cryo-scanning EM (SEM), and cryo-transmission EM. We focused on the structure of the IMV particle, both after isolation and in the context of viral entry. For the latter, we used high-resolution cryo-SEM combined with cryofixation, as well as a novel approach we developed for investigating vaccinia IMV bound to plasma membrane fragments adsorbed onto EM grids. Our analysis revealed that the IMV is made up of interconnected cisternal and tubular domains that fold upon themselves via a complex topology that includes an S-shaped fold. The viral tubules appear to be eviscerated from the particle during viral infection. Since the structure of the IMV is the result of a complex assembly process, we also provide a working model to explain how a specialized smooth-ER domain can be modulated to form the IMV. We also present theoretical arguments for why it is highly unlikely that the IMV is surrounded by only a single membrane.
Steroids for acute sinusitis.

BACKGROUND Acute sinusitis is a common reason for primary care visits. It causes significant symptoms and often results in time off work and school. OBJECTIVES We examined whether intranasal corticosteroids (INCS) are effective in relieving symptoms of acute sinusitis. SEARCH STRATEGY We searched the Cochrane Central Register of Controlled Trials (The Cochrane Library Issue 4, 2006), MEDLINE (January 1966 to December 2006), EMBASE (1990 to June 2006) and bibliographies of included studies. SELECTION CRITERIA Randomized controlled trials (RCTs) were considered eligible if they compared INCS treatment to placebo treatment of a control group for acute sinusitis; acute sinusitis was defined by clinical diagnosis and confirmed by radiological evidence or by nasal endoscopy. The primary outcome was the proportion of participants with either resolution or improvement of symptoms. Secondary outcomes were any adverse events that required discontinuation of treatment, drop-outs before the end of the study, rates of relapse, complications and return to school or work. DATA COLLECTION AND ANALYSIS Two review authors independently extracted the data, assessed trial quality and resolved discrepancies by consensus. MAIN RESULTS Four studies with 1943 participants met the inclusion criteria. The trials were well designed, double-blind, placebo controlled in which the included participants had acute sinusitis. The treatment assigned was INCS versus control treatment for 15 or 21 days. The rates of loss to follow up in the studies were 7%, 11%, 41% and 10%. When the results from the three trials included in the meta-analysis were combined, participants receiving INCS were more likely to have resolution or improvement of symptoms than those receiving placebo (73% versus 66.4%; RR 1.11; 95% CI 1.04 to 1.18). Higher doses of INCS had a stronger effect on improvement or complete relief of symptoms: for mometasone furoate (MFNS) 400 mcg versus 200 mcg, (RR 1.10; 95% CI 1.02 to 1.18 versus RR 1.04; 95% CI 0.98 to 1.11). No significant adverse events were reported and there was no significant difference in the drop-out and recurrence rate for the two treatment groups and for groups receiving higher doses of INCS. AUTHORS' CONCLUSIONS For acute sinusitis confirmed by radiology or nasal endoscopy, current evidence is limited, but supports the use of INCS as a monotherapy or as an adjuvant therapy to antibiotics. Clinicians should weigh the modest but clinically important benefits against possible minor adverse events when prescribing therapy.
Redirecting DNS for Ads and Profit

Internet Service Providers (ISPs) increasingly try to grow their profit margins by employing “error traffic monetization,” the practice of redirecting customers whose DNS lookups fail to advertisement-oriented Web servers. A small industry of companies provides the associated machinery for ISPs to engage in this monetization, with the companies often participating in operating the service as well. We conduct a technical analysis of DNS error traffic monetization evident in 66,000 Netalyzr sessions, including fingerprinting derived from patterns seen in the resulting ad landing pages. We identify major players in this industry, their ISP affiliations over time, and available user opt-out mechanisms. One monetization vendor, Paxfire, transgresses the error-based model and also reroutes all user search queries to Bing, Yahoo, and (sometimes) Google via proxy servers controlled or provided by Paxfire.
The Validity of Probability Samples in Research on Deafness

This article addresses the problem of small nonprobability samples in research in the education of the deaf and hard of hearing in the face of a current and increasing emphasis on "scientifically based research" as required by recent No Child Left Behind (NCLB) federal legislation. The authors examine the gains and losses in information generated using non-probability samples in our field, describe the conditions required for generalizable research results, and identify several factors in the field of research in the education of the deaf that limit the ability to generate probability samples. Finally, the authors consider possible solutions to the problem, including more creative recruitment strategies, alternate research designs, and alternate reviewing strategies.
Meta-Analysis of the Relationships Between Social Support and Well-Being in Children and Adolescents

Research has started to explore the associations between social support and well-being among children and adolescents, but the overall relationship is still unclear. This study explored: (1) the overall association between social support and well-being, (2) the association differences among categories of well-being, (3) the association differences among different types of social support measures, (4) the association differences among different support sources, and (5) whether the association between social support and well-being changed with participants' age. Two hundred forty-six studies were collected and analyzed, and the results indicated a positive but small association between social support and well-being. Additionally, moderator analyses indicated that social support was more strongly associated with self-concept, perceived support was more strongly associated with well-being, support from teachers and school personnel was more strongly associated with well-being, and the association between soci.
Dry mass and cell area changes in Ehrlich mouse ascites carcinoma cells after complement-fixation reaction measured by interference microscopy.

Ehrlich ascites carcinoma cells from Swiss mice were treated with rabbit antiserum and rabbit normal serum in the presence of complement. The dry mass changes and cell size changes, as represented by cell area changes, were measured by the interference microscope with a half-shade eyepiece and an eyepiece micrometer. The antiserum-treated cells were found to have a loss of at least 49.1 per cent of their mean dry mass, and an increase of 253.0 per cent of their cell area, at the end of a 3-hour treatment. The normal serum-treated cells had only an insignificant loss of 3.3–3.9 per cent of their mean dry mass and an 11.7 per cent decrease in their cell area. The theory of the mode of antibody reaction is discussed, and we believe the primary effect is on the cell membrane: the permeability of the cell membrane is altered to permit the dry mass of the cell to leak out while the increased intracellular content of water causes the cell to swell.
Why Community? Reading Difference and Singularity with Community

Geographers have increasingly recognised that communities are not homogeneous social formations but contain great diversity and are meaningful in a variety of material, relational and political ways. This has resulted in the apparently contradictory notion of “community with difference”; that community may be performed even while heterogeneity and disagreement are present. But geographers have yet to address satisfactorily the question of why communities continue to be the subject of fascination and study when attempts at definition have proved so problematic. Following on from Young's critique of community, this paper first engages the work of Nancy and Secomb to consider Nancy's conceptualisation of ‘singularity’ as a way to explain the human construction of—and possible need for—notions of community. In short we address the why community? question. Using a rural Australian case study, we demonstrate that meanings of community reflect many differences. This case also illustrates the role of human singularity in the negotiation of these differences, defining the manner in which individual perspectives of community are articulated as well as underpinning people's responses and struggles when ideas of community are challenged.
Ethical beliefs, work problem-solving strategies and learning styles as mediators of tourism marketing entrepreneurialism

This study investigates levels of entrepreneurial motivation associated with a tourism industry marketing business together with three types of mediating variables, namely fundamental ethical beliefs, preferred problem-solving strategies and favoured learning styles. A number of interesting and potentially useful results are revealed in this study: individuals who would eschew tourism management entrepreneurialism are found less likely to be innovative and less likely to rely upon preparation as a learning style, but rather seek to rely solely upon rote learning; in contrast, those who expressed cautious interest in such a business future are found more likely to be innovative and to value practicality as a learning style. Those prepared more confidently to pursue this type of entrepreneurial future are characterised by their assent to the ethical precept of genuineness; ethical precepts associated with hard work, helpfulness and genuineness are individually found to be related to the expression of a cautious interest in tourism marketing entrepreneurialism in the future life of the respondent. Significant associations between gender and tourism marketing entrepreneurialism are also highlighted. Implications of these results and also directions for future research are discussed.
Effects of Stimulus Characteristics and Background Music on Foreign Language Vocabulary Learning and Forgetting

This study examined the effects of three stimulus variables and background music on paired-associate learning of foreign language (FL) vocabulary. The stimulus variables were the frequency and concreteness of the native language (L1) words and the (phonotactical) typicality of the FL words. Sixty-four L1-FL pairs were presented for learning six times, followed by a recall test after the second, fourth, and sixth learning round. A fourth recall test took place 1 week later. Typical FL words, FL words paired with frequent L1 words, and FL words paired with concrete L1 words were learned better than atypical FL words and FL words paired with infrequent and abstract L1 words, respectively. More learning occurred in the music condition than in the silent condition. The results are interpreted in terms of differences between memory representations of L1 words, differences in the phonological coding enabled by the FL words, and individual learner differences.
Beyond Legalism: Towards a Thicker Understanding of Transitional Justice

The field of transitional justice is increasingly characterized by the dominance of legalism to the detriment of both scholarship and practice. The first part of the paper examines what is meant by legalism and its consequences in the field through a number of overlapping themes: ‘legalism as seduction’, the ‘triumph’ of human rights, and the tendency towards ‘seeing like a state’. The second part considers a number of correctives to such leanings which are analysed as encouraging legal humility, exploring the human rights as development axis, and finally developing a criminology of transitional justice. As law's place at the heart of transition from conflict is now secure, the time is right for a more honest appraisal of the limitations of legalism and a correspondingly greater willingness to countenance the role of other [non-legal] actors and forms of knowledge. ‘Letting go of legalism’ will both thicken the subject and deliver more effective change on the ground.
Photodynamic Therapy with Pyropheophorbide‐a Methyl Ester in Human Lung Carcinoma Cancer Cell: Efficacy, Localization and Apoptosis ¶

Pyropheophorbide‐a methyl ester (MPPa) is a semisynthetic photosensitizer derived from chlorophyll a. The absorption peak of MPPa in organic solvent and in cells was at 667 and 674 nm, respectively. 3‐(4,5‐Dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide reduction assay showed that MPPa had no dark cytotoxicity. In vitro photodynamic activity was extensively evaluated using a human lung carcinoma cancer cell line (NCI‐h446). MPPa exhibited no genotoxicity, as assayed by single‐cell gel electrophoresis. Using confocal laser scanning microscopy and organelle‐specific fluorescent probes, MPPa was found to localize in the intracellular membrane system, namely the endoplasmic reticulum, Golgi apparatus, lysosomes and mitochondria, in the NCI‐h446 cells. Furthermore, nuclear staining and DNA gel electrophoresis revealed that DNA condensation and fragmentation occurred post–photodynamic therapy, indicating the cell death was in the apoptotic mode.
Having Their Lives Narrowed Down? The State of Black Women’s College Success

Contradictory trends emerge relative to Black women’s college success: They have doubled their enrollment rates in thirty years but their graduation rates remain behind those of White and Asian women. This integrative, interdisciplinary review of both student- and institutional-level factors explores the role of individual characteristics and backgrounds, relationships, and institutional support structures relative to Black women’s success in college. The findings reveal that African American women’s lives may be narrowed down in research that includes them through (a) an emphasis on individual factors in college success instead of institutional (within college campuses) or larger sociostructural issues (race, class, or gender inequities in the larger society), (b) a lack of analysis of within-group difference among Black women, and (c) framing the notion of success as persistence or completion of a student’s degree program instead of self-identified or unique notions of success such as collective uplift, well-being, or satisfaction.
On the double commutation method

We provide a complete spectral characterization of the double commutation method for general Sturm-Liouville operators which inserts any finite number of prescribed eigenvalues into spectral gaps of a given background operator. Moreover, we explicitly determine the transformation operator which links the background operator to its doubly commuted version (resulting in extensions and considerably simplified proofs of spectral results even for the special case of Schrodinger-type operators).
Recognition and Comprehension of "Narrow Focus" by Young Adults With Prelingual Hearing Loss Using Hearing Aids or Cochlear Implants.

Purpose The stressed word in a sentence (narrow focus [NF]) conveys information about the intent of the speaker and is therefore important for processing spoken language and in social interactions. The ability of participants with severe-to-profound prelingual hearing loss to comprehend NF has rarely been investigated. The purpose of this study was to assess the recognition and comprehension of NF by young adults with prelingual hearing loss compared with those of participants with normal hearing (NH). Method The participants included young adults with hearing aids (HA; n = 10), cochlear implants (CI; n = 12), and NH (n = 18). The test material included the Hebrew Narrow Focus Test (Segal, Kaplan, Patael, & Kishon-Rabin, in press), with 3 subtests, which was used to assess the recognition and comprehension of NF in different contexts. Results The following results were obtained: (a) CI and HA users successfully recognized the stressed word, with the worst performance for CI; (b) HA and CI comprehended NF less well than NH; and (c) the comprehension of NF was associated with verbal working memory and expressive vocabulary in CI users. Conclusions Most CI and HA users were able to recognize the stressed word in a sentence but had considerable difficulty understanding it. Different factors may contribute to this difficulty, including the memory load during the task itself and linguistic and pragmatic abilities. Supplemental Material https://doi.org/10.23641/asha.5572792.
Daphnia inhibits the emergence of spatial pattern in a simple consumer-resource system.

Spatial self-organization can occur in many ecosystems with important effects on food web dynamics and the maintenance of biodiversity. The consumer-resource interaction is known to generate spatial patterning, but only a few empirical studies have investigated the effect of the consumer on resource distribution. Here we report results from a large aquatic mesocosm experiment used to investigate the effect of the consumer Daphnia magna on the distribution of its resource, the green algae Chlorella vulgaris. We maintained large tanks with capacity for 26 ,000 L with either algae or both algae and Daphnia in different temperature conditions. We found that the presence of D. magna inhibited spatial structure in algal distribution that arose as a consequence of increasing temperature. We conjecture that this homogenization effect might be caused by a combination of high mobility combined with high rates of algal consumption by Daphnia. Our study emphasizes the importance of both local constraints on growth and behavioral responses in either promoting or suppressing spatial self-organization in natural populations.
Multimodal databases of everyday emotion: facing up to complexity

In everyday life, speech is part of a multichannel system involved in conveying emotion. Understanding how it operates in that context requires suitable data, consisting of multimodal records of emotion drawn from everyday life. This paper reflects the experience of two teams active in collecting and labelling data of this type. It sets out the core reasons for pursuing a multimodal approach, reviews issues and problems for developing relevant databases, and indicates how we can move forward both in terms of data collection and approaches to labelling.