Miracle-dz/UniFAR-FTUs huggingface dataset:
Safety and efficacy of sonothrombolysis using bilateral TCD monitoring by diagnostic 2 MHz probes - a pilot study.

INTRODUCTION Sonothrombolysis is a new treatment method for patients with acute ischemic stroke (IS). Various ultrasound frequencies and intensities are being tested these days. The aim of this pilot study was to assess the safety and efficacy of sonothrombolysis using 2 diagnostic probes and bilateral monitoring in patients with acute occlusion of the middle cerebral artery (MCA). PATIENTS AND METHODS Twelve consecutive IS patients (7 males; age 47 - 78, average 64.1 ± 9.4 years) with acute MCA occlusion and contraindication of thrombolysis were included in the study. 60-min bilateral 2-MHz pulsed-wave Doppler monitoring of the area of occlusion was performed in all patients (Group 1). The control group consisted of 37 IS patients (20 males; age 32 - 78, average 62.2 ± 12.1 years) treated with standard sonothrombolysis and selected from the Thrombotripsy Study database (Group 2). The differences in number of recanalized arteries after a 1 h treatment, independent patients (modified Rankin scale [mRS] value of 0 - 2) after 90 days and symptomatic intracerebral hemorrhages (SICH) were statistically evaluated. RESULTS Complete recanalization was found in 4 (30.0%) Group 1 and in 12 (32.4%) Group 2 patients. Seven (58.3%) Group 1 and 22 (59.5%) Group 2 patients were independent after 90 days. SICH was found in none of Group 1 patients and in 1 (2.7%) of the Group 2 patients (P>0.05 in all cases). CONCLUSION In this pilot study, sonothrombolysis using 2 probes and bilateral monitoring is safe but not more effective than standard sonothrombolysis in acute IS patients with MCA occlusion.
Validation of a menopause quality of life scale: the MENCAV scale.

OBJECTIVE To assess the criterion validity, construct validity and test-retest reliability of the MENCAV menopause quality of life scale. METHODS Observational, cross-sectional study covering a random sample of 470 women aged 40-60 years. Two questionnaires were administered, namely, the MENCAV, made up of 37 items in 5 dimensions, and the SF-36. A confirmatory factorial analysis was performed, leaving a final scale with 35 items. To evaluate criterion validity, the relationship between the physical and mental health dimensions of both instruments was estimated. Two experts assessed 40 menopausal women and recorded the correlations with the MENCAV. Construct validity was evaluated by comparing the mean scores of menopausal and non-menopausal women for each of the MENCAV dimensions. To assess test-retest reliability, we estimated the correlation between MENCAV scores when the questionnaire was administered on two separate occasions, 2 weeks apart. RESULTS The final questionnaire comprised 35 items divided into 5 dimensions. All dimensions displayed high levels of reliability, with Cronbach's alpha values ranging from 0.71 to 0.91, and Cronbach's alpha for the total scale being 0.89. The intraclass correlation was 0.77 (95% CI: 0.61-0.87). Correlations between the questionnaire and the SF-36 were significant; and those with the experts were significant for the physical, mental and sexual dimensions. CONCLUSIONS The MENCAV is a valid and reliable questionnaire for assessing quality of life in menopausal women.
THE CLOSED TREATMENT OF COMMON FRACTURES

Preparing the books to read every day is enjoyable for many people. However, there are still many people who also don't like reading. This is a problem. But, when you can support others to start reading, it will be better. One of the books that can be recommended for new readers is the closed treatment of common fractures. This book is not kind of difficult book to read. It can be read and understand by the new readers.
Genetic lesions in chronic lymphocytic leukemia: what’s ready for prime time use?

Chronic lymphocytic leukemia (CLL) is a frequent CD5+ B-cell neoplasia that involves peripheral blood, bone marrow, lymph nodes and other lymphoid tissues. The median age of patients at diagnosis of CLL is around 70 years old and the prognosis is extremely variable. In spite of some advances in its
A lacZ-pbpB gene fusion coding for an inducible hybrid protein that recognizes localized sites in the inner membrane of Escherichia coli

An in-phase gene fusion consisting of the 5'-terminal 1,314 base pairs (bp) of the structural gene for beta-galactosidase (lacZ) and the 3'-terminal 1,644 bp of the structural gene coding for penicillin-binding protein 3 (pbpB) of Escherichia coli was constructed and cloned in the plasmid pDIAM64. The product of the fusion gene was a remarkably stable protein with an apparent molecular weight of 110,000 (p110) that retained the ability to covalently interact with beta-lactam antibiotics. The fusion protein was found associated with the membrane at low levels of induction, but it accumulated in the cytoplasm of cells induced for a long time as inclusion bodies of high density. Inclusion bodies were localized at defined positions corresponding to septal sites in all of the pDIAM64-containing strains tested except PAT84 and GD113 (which carry the ftsZ84 mutant allele). These findings indicate a possible role of the FtsZ protein in the integration of Pbp3 into the membrane and in septum localization during the cell division cycle.
The relationship between accounting students’ personality, professional skepticism and anticipatory socialization

ABSTRACT Professional skepticism is an essential component of every successful audit. Research in psychology identified the trait professional skepticism as an enduring personality construct. The current study examines the relationship between the Big Five personality characteristics and accounting students’ trait professional skepticism and their level of anticipatory socialization. Using a sample of 293 accounting students close to graduation, results indicate a positive relationship between Big Five personality characteristics and the trait professional skepticism, and between personality and anticipatory socialization. There is also a positive relationship between professional skepticism and anticipatory socialization. These results are useful to accounting educators who attempt to socialize accounting students into the profession.
Isotopic Evidence That Dragonflies (Pantala flavescens) Migrating through the Maldives Come from the Northern Indian Subcontinent

Large numbers of the Globe Skimmer dragonfly (Pantala flavescens) appear in the Maldives every October–December. Since they cannot breed on these largely waterless islands, it has recently been suggested that they are “falling out” during a trans-oceanic flight from India to East Africa. In addition, it has been suggested that this trans-oceanic crossing is just one leg of a multi-generational migratory circuit covering about 14,000–18,000 km. The dragonflies are presumed to accomplish this remarkable feat by riding high-altitude winds associated with the Inter-tropical Convergence Zone (ITCZ). While there is considerable evidence for this migratory circuit, much of that evidence is circumstantial. Recent developments in the application of stable isotope analyses to track migratory dragonflies include the establishment of direct associations between dragonfly wing chitin δ 2H values with those derived from long-term δ 2H precipitation isoscapes. We applied this approach by measuring wing chitin δ 2H values in 49 individual Pantala flavescens from the November–December migration through the Maldives. Using a previously established spatial calibration algorithm for dragonflies, the mean wing δ 2H value of −117±16 ‰ corresponded to a predicted mean natal ambient water source of −81 ‰, which resulted in a probabilistic origin of northern India, and possibly further north and east. This strongly suggests that the migratory circuit of this species in this region is longer than previously suspected, and could possibly involve a remarkable trans-Himalayan high-altitude traverse.
Surgical Management for Giant liver Hemangiomas Greater Than 20 cm in Size

Background/Aims The aim of this study was to investigate the primary management experience for giant liver hemangiomas greater than 20 cm in size. Methods Records of patients referred for evaluation of radiologically and/or histopathologically proven giant liver hemangiomas between January 2007 and March 2010 were retrospectively analyzed. The reasons for referral, results of imaging studies, preoperative and surgical treatments, and outcome were reviewed. Results A retrospective analysis was performed for 14 patients diagnosed with a giant hemangioma on the basis of an imaging study and/or a histopathological examination. All cases were diagnosed as giant liver hemangioma with at least one lesion greater than 20 cm in size. Abdominal discomfort was the main presenting complaint for the referral in 9 patients (64.2%). Abdominal ultrasound established the diagnosis in 12 patients (85.7%). Twelve patients underwent liver resection, 2 of whom underwent staged resection. Enucleation was performed in 2 patients. Selective transcatheter arterial embolization was implemented in 9 patients. Postoperative morbidity occurred in 3 patients (21.4%). No complications related to the hemangiomas occurred during follow up. Conclusions Liver resection is indicated for giant liver hemangiomas with abdominal discomfort, especially for lesions greater than 20 cm in size. Staged operations are performed for patients with multiple lesions. Preoperative selective transcatheter arterial embolization alleviates progressive abdominal pain.
Understanding teacher well-being and motivation : measurement, theory, and change over time

Teacher well-being and motivation play important roles in teacher and student experiences at school. When teachers are faring well and feeling motivated to teach, they are more effective in their teaching, leave the profession less often, and promote motivation and achievement among their students. In this dissertation, three studies that investigated teacher well-being and motivation were conducted with the aim of advancing our understanding of the two constructs, as well as how they can be promoted among teachers. Study 1 involved conceptualising, developing, and testing the Teacher Well-Being Scale, which measures three factors of teacher well-being: workload well-being, organisational well-being, and student interaction well-being. Among a sample of 603 practicing teachers, results revealed that the new measure functioned similarly across the different demographic groups in the sample and that the three factors of well-being related as expected with other constructs (stress, job satisfaction, and flourishing). Study 2 involved elaborating and testing an explanatory model of teacher well-being, motivation, job satisfaction, and affective organisational commitment that was based in self-determination theory (Deci & Ryan, 1985, 2002). Using the same sample as Study 1, structural equation modelling provided support for the model’s main relationships. In addition, there were some unexpected findings that provide directions for future research (e.g., a double-sided view of autonomy revealing that it can be associated with positive and negative types of motivation). Study 3 involved examining growth curve models of change in teacher well-being and self-efficacy for teaching over two to three months. Among a sample of 71 practicing teachers, the findings showed that teacher well-being was stable over time, whereas self-efficacy for classroom management increased (the other two types of self-efficacy that were examined, self-efficacy
Toll‐like receptor (TLR)‐2 and TLR‐4 regulate inflammation, gliosis, and myelin sparing after spinal cord injury

Activation of macrophages via toll‐like receptors (TLRs) is important for inflammation and host defense against pathogens. Recent data suggest that non‐pathogenic molecules released by trauma also can trigger inflammation via TLR2 and TLR4. Here, we tested whether TLRs are regulated after sterile spinal cord injury (SCI) and examined their effects on functional and anatomical recovery. We show that mRNA for TLR1, 2, 4, 5, and 7 are increased after SCI as are molecules associated with TLR signaling (e.g. MyD88, NFκB). The significance of in vivo TLR2 and TLR4 signaling was evident in SCI TLR4 mutant (C3H/HeJ) and TLR2 knockout (TLR2−/−) mice. In C3H/HeJ mice, sustained locomotor deficits were observed relative to SCI wild‐type control mice and were associated with increased demyelination, astrogliosis, and macrophage activation. These changes were preceded by reduced intraspinal expression of interleukin‐1β mRNA. In TLR2−/− mice, locomotor recovery also was impaired relative to SCI wild‐type controls and novel patterns of myelin pathology existed within ventromedial white matter – an area important for overground locomotion. Together, these data suggest that in the absence of pathogens, TLR2 and TLR4 are important for coordinating post‐injury sequelae and perhaps in regulating inflammation and gliosis after SCI.
Teriparatide – Indications beyond osteoporosis

Osteoporosis is a condition of impaired bone strength that results in an increased risk of fracture. The current and most popular pharmacological options for the treatment of osteoporosis include antiresorptive therapy, in particular, oral bisphosphonates (alendronate, risedronate, ibandronate). Anabolic agents like teriparatide have widened our therapeutic options. They act by directly stimulating bone formation and improving bone mass quantity and quality. Two forms of recombinant human parathyroid hormone (PTH) are available : full-length PTH (PTH 1–84; approved in the EU only) and the 1–34 N-terminal active fragment of PTH (teriparatide, US FDA approved). This review aims to discuss the benefits of teriparatide beyond the currently licensed indications like fracture healing, dental stability, osteonecrosis of jaw, hypoparathyroidism, and hypocalcemia.
Relationships between digestibilities of food components and characteristics of wheats ( Triticum aestivum ) introduced as the only cereal source in a broiler chicken diet

1. The aim of the experiment was to establish relationships between chemical or physical characteristics of wheats ( Triticum aestivum ) and digestibilities of food components in broiler chickens fed on wheat-based diets. Twenty-two wheat samples, each differing by their cultivar origin, were included at 550 g/kg in diets offered to male Ross broiler chicks. The other main ingredients were soya bean meal (340 g/kg) and rapeseed oil (68.5 g/kg). Diets were given as pellets. 2. In vitro viscosities of wheats measured as potential applied viscosity (PAV) or real applied viscosity (RAV) varied between 1.91 and 6.03, or between 0.95 and 3.81 ml/g (dry matter basis), respectively. Hardness of wheats varied between 17 (soft) and 95 (very hard), and lipase activity of wheats varied from 1 to 13.6 (relative scale). 3. PAV and RAV values were not significantly correlated with hardness. PAV and RAV values were correlated with (80:20) ethanol:water insoluble.961, 0.932, respectively), with the amount of water retained by cell walls ( r .656, 0.492, respectively), and with lipase activity ( r = 0.600, 0.532, respectively. 4. Hardness was correlated with ash ( r = -0.484), nitrogen ( r = 0.534), mean particle size of wheat flours ( r = 0.631), and specific energy of pelleting ( r = -0.574). 5. Wheat diets were evaluated in two assays with 3-week-old chicks, with 11 diets per assay. In each assay, a balance experiment was carried out using the total collection method. Growth performance was also measured during the balance experiment. 6. In vitro viscosity parameters were negatively correlated with diet AME n . 05), lipid digestibility ( P < 0.05) and, to a lesser extent, protein digestibility ( P < 0.05). In vitro viscosity data were positively correlated with food:gain ratio ( P < 0.05) and water loss parameters ( P < 0.05), and were not significantly ( P > 0.05) correlated with starch digestibility. 7. Wheat hardness-related parameters were correlated ( P < 0.01) wi.273, -0.305, 0.212, respectively). 8. Wheat lipase activity was negatively c.179; P < 0.05) and starch ( r = -0.225; P < 0.01) digestibilities and with individual diet AME n ( r = -0.266; P < 0.001). Individual diet AME n . 175) with the values calculated by the EU AME n prediction equation (Fisher and McNab, 1987). Among the correlations observed between the individual measured AME n :EU predicted AMEn ratio and wheat parameters ( P .05), the correlation obtained with wheat lipase was the highest ( r = -0.195). The correlations with lipase could be explained in part by strong correlations between lipase and in vitro viscosity parameters.
Candidate Pathway Based Analysis for Cleft Lip with or without Cleft Palate

The objective of this research was to identify potential biological pathways associated with non-syndromic cleft lip with or without cleft palate (NSCL/P), and to explore the potential biological mechanisms underlying these associated pathways on risk of NSCL/P. This project was based on the dataset of a previously published genome-wide association (GWA) study on NSCL/P (Beaty et al. 2010). Case-parent trios used here originated from an international consortium (The Gene, Environment Association Studies consortium, GENEVA) formed in 2007. A total of 5,742 individuals from 1,908 CL/P case-parents trios (1,591 complete trios and 317 incomplete trios where one parent was missing) were collected and genotyped using the Illumina Human610-Quad array. Candidate pathways were selected using a list of 356 genes that may be related to oral clefts. In total, 42 candidate pathways, which included 1,564 genes and 40,208 SNPs were tested. Using a pathway-based analysis approach proposed by Wang et al (2007), we conducted a permutation-based test to assess the statistical significance of the nominal p-values of 42 candidate pathways. The analysis revealed several pathways yielding nominally significant p-values. However, controlling for the family wise error rate, none of these pathways could retain statistical significance. Nominal p-values of these pathways were concentrated at the lower tail of the distribution, with more than expected low p-values. A permutation based test for examining this type of distribution pattern yielded an overall p-value of 0.029. Thus, while this pathway-based analysis did not yield a clear significant result for any particular pathway, we conclude that one or more of the genes and pathways considered here likely do play a role in oral clefting.
Long‐Term Cold Acclimation Leads to High Q10 Effects on Oxygen Consumption of Loggerhead Sea Turtles Caretta caretta

We monitored oxygen consumption (V̇o2, body temperatures (Tb), submersion intervals, and circadian rhythms of V̇o2 in nine loggerhead turtles during a 6‐mo period. The turtles originated from the Tyrhennian Sea, South Italy (40°51′N, 14°17′E) and were kept in indoor tanks at constant photoperiod while being subject to the seasonal decline in water temperature (Tw = 27.1° to 15.3°C). From summer to winter, all turtles underwent profound reductions in V̇o2 (Q10 = 5.4). Simultaneously, their activity was greatly reduced and submergence intervals increased. Over 24‐h periods, however, the turtles showed no circadian rhythm in activity or V̇o2. However, there was a significant positive correlation between the proportion of a day spent actively swimming and V̇o2. Tb's were not significantly different from Tw and followed the same seasonal decline. A second experiment was conducted to establish the effect of short‐term exposure to various temperatures on V̇o2. Tb equilibrated with the experimental Tw within 3 h. The metabolic responses were again positively correlated with changes in Tw , but this time the corresponding Q10 was only 1.3. On the basis of the range of body masses of the turtles used in this study (2–60 kg), the intraspecific scaling exponent for V̇o2 was 0.353.
Gender Norms, Housework, and Class: A Study of Korean Time Use Survey

Abstract This study asks whether and how gender norms explain the time spent on housework in dual-earner households. In doing so, I explore the ways in which gender norms affect housework in specific class contexts. Using the 2004 Korean Time Use Survey (Korea Statistics Office, 2004), I focus on and define gender norms in the following way: individuals hold egalitarian attitudes if they are opposed to the traditional sexual division of labor. Regression analysis shows that the egalitarian attitudes of husbands, rather than wives, particularly those who lived with egalitarian wives, were positively associated with their own contribution to housework and food-related activities. Provision of child care, however, was barely affected by a woman's economic resources or gender norms, while the effects of the wife's class and economic resources also have an impact, along with gender norms.
Reducing the use of seclusion and restraint in segregated special education school settings through implementation of the Collaborative Problem Solving Model

REDUCING THE USE OF SECLUSION AND RESTRAINT IN SEGREGATED SPECIAL EDUCATION SCHOOL SETTINGS THROUGH IMPLEMENTATION OF THE COLLABORATIVE PROBLEM SOLVING MODEL By BethAnn Glew May 2012 Dissertation supervised by Launcelot Brown, Ph.D. The intent of this study was to determine whether implementation of the Collaborative Problem Solving (CPS) model, that has proven successful in psychiatric settings, was equally effective in reducing restrictive practices in public school settings. Many peer-reviewed, published reports suggest that educators are poorly prepared to manage the extremely challenging behaviors of aggression and non-compliance, which are common in students classified with an emotional disturbance (ED). Too often educators rely on ineffective, potentially harmful interventions such as seclusion and restraint, which adversely impact students as well as staff. The nonrandom sample was comprised of students enrolled in two segregated special education schools located in large communities in northwestern Pennsylvania. The enrollment was 69 students in School A and 26 students in School B. The schools serve students, kindergarten through twelfth grade. All students were evaluated and classified as ED by their referring home school district as per Chapter 14 Regulations of the Pennsylvania Department of Education and received one-hundred percent of their special education program in this restrictive school-based environment. This study used a quasi-experimental, pre-test-post-test research design and used two separate existing electronic data sources to test for relationships between the implementation of the CPS model and identified variables (standardized measures of externalizing maladaptive behaviors, incidents of aggression, noncompliance, and disruption, as well as incidents and duration of seclusion and restraint). The analyses included frequency comparisons, a series of Wilcoxon Signed Rank Tests, a series of dependent samples T-tests, and two-way repeated measures analyses of variance. Implementation of the model reduced the incidents of aggression, noncompliance, and disruption, as well as incidents and duration of seclusion and restraint. However, only one of the schools in the study demonstrated a statistically significant reduction of aggression incidents and the use of restraint procedures. The results suggest that when implemented with fidelity, the research-based CPS model is a promising, preventative behavior approach for students classified with ED in a segregated special education school.
STUDIES ON INSULIN BIOSYNTHESIS

Islet tissue from the goosefish (Lophius piscatorius) was incubated in the presence of leucine-H3. The tissue was then separated into subcellular fractions and the radioactivity determined in total acid alcohol-soluble proteins, insoluble proteins, and insulin. At any time, microsomal protein had a higher activity than secretion granule protein. Pulse-chase experiments further suggest the microsomes as primary sites of protein synthesis. The data are evidence for microsomal synthesis of insulin and for its subsequent transfer into the secretion granules.