Miracle-dz/UniFAR-FTUs huggingface dataset:
Enterprise stent for waffle-cone stent-assisted coil embolization of large wide-necked arterial bifurcation aneurysms

Background: Large wide-necked arterial bifurcation aneurysms present a unique challenge for endovascular coil embolization treatment. One technique described in the literature deploys a Neuroform stent into the neck of the aneurysm in the shape of a waffle-cone, thereby acting as a scaffold for the coil mass. This case series presents four patients with large wide-necked bifurcation aneurysms treated with the closed-cell Enterprise stent using the waffle-cone technique. Case Description: Four patients (59 ± 18 years of age) with large wide-necked arterial bifurcation aneurysms (three basilar apex and one MCA bifurcation) were treated with the waffle-cone technique using the Enterprise stent as a supporting device for stent-assisted coil embolization. Three of the patients presented with aneurysmal subarachnoid hemorrhage (Hunt-Hess 2-3; Fisher Grade 3-4). There was no procedural morbidity or mortality associated with treatment itself. One aneurysm was completely obliterated, and three had small residual necks. One patient developed an area of PCA infarct and visual field cut one month after the procedure and required recoiling of the residual neck. The flared ends of the Enterprise stent remodeled the aneurysm neck by conforming to the shape of the neck without any technical difficulty, resulting in a stable scaffold holding the coils into the aneurysm. Conclusion: The closed cell construction, flexibility, and flared ends of the Enterprise stent allow it to conform to the waffle-cone configuration and provide a stable scaffold for coil embolization of large wide-necked arterial bifurcation aneurysms. We have had excellent initial results using the Enterprise stent with the waffle-cone technique. However, this technique is higher risk than standard treatment methods and therefore should be reserved for large wide-necked bifurcation aneurysms where Y stenting is needed, but not possible, and surgical clip ligation is not an option.
P and S wave travel time inversions for subducting slab under the island arcs of the northwest Pacific

We have observed slablike high P and S velocity anomalies around the Wadati-Benioff zone under island arcs of the northwest Pacific through travel time tomographic inversions. Nineteen years of International Seismological Centre travel time residuals for events and stations in this large region are used. Analyses of resolution and noise show that the images are generally well resolved. The images illustrate that slab anomalies are continuous along strike in most parts of the upper mantle of the region and become contorted and generally broadened with depth. Near the bottom of the upper mantle, fingering of the slabs, including segmenting and spreading, is indicated. The fast anomalies associated with the Japan, Izu-Bonin, and Mariana subduction zones tend to flatten to subhorizontal at depth, while downward spreading may occur under parts of the Mariana and Kurile arcs. The fast anomalies below 700 km are not in the shape of a single coherent sheet. The principal compressional axes of focal mechanisms in the region consistently follow the downdip direction of the high-velocity slab, even when it bends to subhorizontal at depth. The depth at which compression begins to dominate the downdip stress regime in the slab apparently depends on bending of the slab and its dip. Slab fingering and intense deep seismicity probably are the consequence of the slab encountering a barrier of some form around the “670-km” discontinuity.
Accurate time-variant analysis of a current-reuse 2.2 GHz 1.3 mW CMOS front-end

This paper presents a 2.2 GHz receiver front-end capable of an extreme current reuse, where the low-noise amplifier, the quadrature mixers and VCOs only draw 1.3 mA from a 1V supply. A careful time-variant analysis is carried out, resulting in a very accurate expression of the conversion gain and bandwidth of the downconverter. A prototype, implemented in a 90 nm CMOS technology, shows 27 dB gain over a 14 MHz bandwidth, with a noise figure of 13 dB. The input-referred 1 dB compression point is −23.7 dBm.
Exhuming the Alps through time: clues from detrital zircon fission‐track thermochronology

The European Alps are a mountain belt that is characterized by a series of discrete orogenic events, which have long been recognized. Despite the inherent episodic nature of orogenic evolution, the Alps have been continuously exhumed, mainly by erosion, but also by normal faulting. Since continental collision started in the late Eocene/Early Oligocene evidence for ongoing erosional exhumation has been preserved in synorogenic sediments that accumulated in basins adjacent to the pro‐ and retro‐side of this double‐vergent mountain belt. This long‐term erosion record can be used to determine exhumation rates. Lag‐times calculated from fission‐track (FT) ages of detrital zircon from synorogenic sediments are fairly constant for the European Alps since the Oligocene–Late Miocene. Although the fast exhuming areas were unroofed at rates of 0.4–0.7 km Myr−1, the overall average exhumation rate is between 0.2 and 0.3 km Myr−1 on a regional scale. The detrital and bedrock zircon FT data of the Alps do not detect the increase in erosion rates since the Pliocene over the past ∼5 Myr, as shown elsewhere. This increase cannot be detected yet with the detrital zircon FT method because not enough rock has been removed to widely expose zircons with Pliocene or younger cooling ages in the Alps. Long term (30 Myr) exhumation rates appear to have been approximately constant when averaged over a sliding time window of about 8 Myr, or depth window of 5 to 10 km (ZFT closure depths); shorter‐term fluctuations are not identified using this method.
Three centuries of dual pressure from land use and climate change on the biosphere

Human land use and anthropogenic climate change (CC) are placing mounting pressure on natural ecosystems worldwide, with impacts on biodiversity, water resources, nutrient and carbon cycles. Here, we present a quantitative macro-scale comparative analysis of the separate and joint dual impacts of land use and land cover change (LULCC) and CC on the terrestrial biosphere during the last ca. 300 years, based on simulations with a dynamic global vegetation model and an aggregated metric of simultaneous biogeochemical, hydrological and vegetation-structural shifts. We find that by the beginning of the 21st century LULCC and CC have jointly caused major shifts on more than 90% of all areas now cultivated, corresponding to 26% of the land area. CC has exposed another 26% of natural ecosystems to moderate or major shifts. Within three centuries, the impact of LULCC on landscapes has increased 13-fold. Within just one century, CC effects have caught up with LULCC effects.
Enteric Bacterial Pathogens in Children with Diarrhea in Niger: Diversity and Antimicrobial Resistance

Background Although rotavirus is the leading cause of severe diarrhea among children in sub-Saharan Africa, better knowledge of circulating enteric pathogenic bacteria and their antimicrobial resistance is crucial for prevention and treatment strategies. Methodology/Principal Findings As a part of rotavirus gastroenteritis surveillance in Maradi, Niger, we performed stool culture on a sub-population of children under 5 with moderate-to-severe diarrhea between April 2010 and March 2012. Campylobacter, Shigella and Salmonella were sought with conventional culture and biochemical methods. Shigella and Salmonella were serotyped by slide agglutination. Enteropathogenic Escherichia coli (EPEC) were screened by slide agglutination with EPEC O-typing antisera and confirmed by detection of virulence genes. Antimicrobial susceptibility was determined by disk diffusion. We enrolled 4020 children, including 230 with bloody diarrhea. At least one pathogenic bacterium was found in 28.0% of children with watery diarrhea and 42.2% with bloody diarrhea. Mixed infections were found in 10.3% of children. EPEC, Salmonella and Campylobacter spp. were similarly frequent in children with watery diarrhea (11.1%, 9.2% and 11.4% respectively) and Shigella spp. were the most frequent among children with bloody diarrhea (22.1%). The most frequent Shigella serogroup was S. flexneri (69/122, 56.5%). The most frequent Salmonella serotypes were Typhimurimum (71/355, 20.0%), Enteritidis (56/355, 15.8%) and Corvallis (46/355, 13.0%). The majority of putative EPEC isolates was confirmed to be EPEC (90/111, 81.1%). More than half of all Enterobacteriaceae were resistant to amoxicillin and co-trimoxazole. Around 13% (46/360) Salmonella exhibited an extended-spectrum beta-lactamase phenotype. Conclusions This study provides updated information on enteric bacteria diversity and antibiotic resistance in the Sahel region, where such data are scarce. Whether they are or not the causative agent of diarrhea, bacterial infections and their antibiotic resistance profiles should be closely monitored in countries like Niger where childhood malnutrition pre-disposes to severe and invasive infections.
The effect of proteolytic activity of starter cultures on technologically important properties of yogurt

Abstract In this study, the effects of proteolytic activity of yogurt starter bacteria on physicochemical and technological properties of yogurt were investigated. Moreover, impact of proteolytic activity and production of exopolysaccharide (EPS) on the performance of each strain were screened. In order to compare the textural properties of yogurt samples, four parameters were evaluated: syneresis, water‐holding capacity, cohesiveness, and hardness. Results showed that strains with high proteolytic activity had lower acidifying activity during fermentation and storage. Samples containing EPS‐producing starter cultures had low proteolytic activity except samples K, L, and M. These differences related to nature and characteristics of each strain. Counts of starter cultures in samples produced using strains with high proteolytic activity were higher than other samples. Textural analysis data showed significant differences (p < .05) among strains in the four tested parameters. Strains with high proteolytic activity showed lower texture properties than other samples. Evaluation of sensory characteristics also showed samples prepared using strains with low or medium proteolytic activity and produced with EPS‐producing strains have higher overall acceptability than other samples. Accordingly, microbial, physicochemical, and sensory properties of produced yogurts confirm that proteolytic activity is one of the most effective factors in quality of product and performance of each strain.
Differential expression of E‐prostanoid receptors in human hepatocellular carcinoma

Recent studies have shown that inhibition of cyclooxygenases (e.g. COX‐2) exerts antitumorigenic effects on hepatocellular carcinomas (HCCs), which are to a significant extent due to the abrogation of PGE2 synthesis. PGE2 acts via differentially regulated prostaglandin receptors (EP1–4). Our study was designed to investigate the expression pattern of EP‐receptors in HCCs and to evaluate the therapeutic potential of selective EP‐receptor antagonists. Using tissue microarrays including a total of 14 control livers, 17 liver cirrhoses, 22 premalignant dysplastic nodules (DNs) and 162 HCCs with different histological grades, the expression of COX‐2, mPGES‐1 and ‐2 and EP1–4‐receptors was analyzed. Western immunoblot analyses were performed to confirm the expression in HCC cell lines. The effects of EP1–4‐receptor antagonism on cell viability and apoptosis were investigated using MTT‐assays and FACS‐analyses, respectively. COX‐2, mPGES‐1 and ‐2 and EP1–4‐receptors were expressed in all HCC tissues. COX‐2 expression was highest in DNs and declined with loss of HCC‐differentiation. With respect to COX‐2 expression, a converse expression of EP1–3 ‐receptors and mPGES‐1 and ‐2 was found in DNs compared to HCCs. Selectively antagonizing EP1‐ and EP3‐receptors reduced the viability of HCC cells in a dose‐dependent manner, which was associated with apoptosis induction. Our results suggest a differential regulation of EP‐receptor subtype expression with dedifferentiation of HCCs in which a converse expression pattern for COX‐2 in comparison to EP1–3‐receptors occurs. Of clinical interest, selectively antagonizing EP1‐ and EP3‐receptors may provide a novel systemic therapeutic approach to the treatment of HCCs. © 2007 Wiley‐Liss, Inc.
Organisational commitment in Malaysian public sector

This paper describes a research project that aims to determine the level of civil servants’ organisational commitment and the factors associated with it. The instruments used to measure organisational commitment, empowerment, job characteristics, and organisational communication were adapted from Allen and Meyer (1990), Spreitzer (1995), Hackman and Oldham (1975), and Downs and Hazen (1977). The findings demonstrated that civil servants appeared to have a higher level of affective commitment with mean value of 3.88 compared to continuance 3.58 and normative commitment 2.92. The study also found that civil servants were psychologically empowered in the department with mean value of 3.71, had experienced a variable opportunity in job with mean 3.51 and were reported to be satisfied with the existing communication in the department with mean value of 3.68. Research findings also showed that there is a correlation between organisational commitment (affective, continuance, and normative commitment) with empowerment, job characteristics, and organisational communication variables. The stepwise regression exhibited that empowerment variable is the most dominant predictor of civil servants’ organisational commitment. Meanwhile, organisational communication variable appeared to be the most significant factor to influence civil servants’ affective commitment. Civil servants with continuance commitment were found to be best predicted by empowerment variable. Finally, civil servants with normative commitment tend to be mostly influenced by job characteristics variable.
The functional and neural basis of belief and desire reasoning

Beliefs and desires are two core mental states that enable us to understand human behaviour. Research in developmental psychology reveals that children understand desires earlier than beliefs, suggesting that the cognitive processes underlying desire reasoning are less complex or less effortful than the processes underlying belief reasoning. Recent findings from studies with adults have identified a specific neural network associated with belief reasoning and found that belief reasoning is cognitively effortful even for healthy adults. However, there has been very little research into the cognitive and neural processes involved in desire reasoning in adults and the extent to which these processes are distinct to those involved in belief reasoning. In Chapter 2, I directly compare the performance of adults with acquired brain damage in belief and desire reasoning tasks, and I suggest the existence of two separate processes in desire reasoning: one linked to self-perspective inhibition and one linked to the reasoning about avoidance desires. In Chapters 3 and 4 I further assess these processes in healthy adults and show that both lead to a measureable cost in the participants’ performance. This provides the first report that desire reasoning (and not only belief reasoning) is cognitively effortful for healthy adults. In Chapter 5, I document a double dissociation in adults with acquired brain damage showing that the processes mediating self-perspective inhibition and those mediating the reasoning about avoidance desires are executive in nature but functionally and neurally distinct. In Chapter 6, I discuss the implications of the findings for the understanding of how beliefs and desires are processed in the adult mind and brain.
Three Essays on International Technology Transfer

Hovhannisyan, Nune (Ph.D., Economics) Three Essays on International Technology Transfer Thesis directed by Professor Wolfgang Keller The transfer of technology is central to modern economic discourse because of its implications for economic growth and long-run convergence of incomes. In this dissertation, I investigate questions on channels and modes of technology transfer, analyzing cross-border flows of goods, ideas and people. In the first chapter, I examine the significance of technological distance for the mode of international knowledge transfer within multinational corporations. The technology transfer within multinationals can happen directly, when the affi liate licenses the technology from the parent, or indirectly, when the affi liate imports intermediate goods with embodied technology. This paper estimates the effect of the affi liates’productivity relative to the frontier —the technology gap —on the choice to license the technology or import it through intermediate goods. The main finding is that a large technology gap of an affi liate favors indirect knowledge transfer through imports. In the second chapter, we examine (with Wolfgang Keller) the importance of cross-border labor flows for innovation. Face-to-face communication may be particularly important for the transfer of technology because technology is best explained and demonstrated in person. This paper studies the role of short-term cross-border labor movements for innovation by estimating the recent impact of U.S. business travel to foreign countries on their patenting rates. The results indicate that business travel has a significant effect on patenting rates
Secure Tropos: a Security-Oriented Extension of the Tropos Methodology

Although security plays an important role in the development of multiagent systems, a careful analysis of software development processes shows that the definition of security requirements is, usually, considered after the design of the system. One of the reasons is the fact that agent oriented software engineering methodologies have not integrated security concerns throughout their developing stages. The integration of security concerns during the whole range of the development stages can help towards the development of more secure multiagent systems. In this paper we introduce extensions to the Tropos methodology to enable it to model security concerns throughout the whole development process. A description of the new concepts and modelling activities is given along with a discussion on how these concepts and modelling activities are integrated to the current stages of Tropos. A real life case study from the health and social care sector is used to illustrate the approach.
A Simple Cipher Governs DNA Recognition by TAL Effectors

TAL Order Xanthomonas bacteria attack their plant hosts by delivering their own transcription-activator–like (TAL) proteins into the plant cell nucleus and alter the plant's gene regulation (see the Perspective by Voytas and Joung). Moscou and Bogdanove (p. 1501, published online 29 October: see the cover) and Boch et al. (p. 1509, published online 29 October) have now discovered how the similar but not identical repeats in the TAL proteins encode the specificity needed for the proteins to find their targets. Each repeat is specific for one DNA base pair, a specificity encoded by hypervariable amino acid positions. Combining several repeats with different amino acids in the hypervariable positions allowed the production of new effectors that targeted new DNA sites. Xanthomonas bacteria use an amino acid–based code to target effector molecules to specific DNA sequences. TAL effectors of plant pathogenic bacteria in the genus Xanthomonas bind host DNA and activate genes that contribute to disease or turn on defense. Target specificity depends on an effector-variable number of typically 34 amino acid repeats, but the mechanism of recognition is not understood. We show that a repeat-variable pair of residues specifies the nucleotides in the target site, one pair to one nucleotide, with no apparent context dependence. Our finding represents a previously unknown mechanism for protein-DNA recognition that explains TAL effector specificity, enables target site prediction, and opens prospects for use of TAL effectors in research and biotechnology.
Adverse Effects of Methylmercury: Environmental Health Research Implications

Background The scientific discoveries of health risks resulting from methylmercury exposure began in 1865 describing ataxia, dysarthria, constriction of visual fields, impaired hearing, and sensory disturbance as symptoms of fatal methylmercury poisoning. Objective Our aim was to examine how knowledge and consensus on methylmercury toxicity have developed in order to identify problems of wider concern in research. Data sources and extraction We tracked key publications that reflected new insights into human methylmercury toxicity. From this evidence, we identified possible caveats of potential significance for environmental health research in general. Synthesis At first, methylmercury research was impaired by inappropriate attention to narrow case definitions and uncertain chemical speciation. It also ignored the link between ecotoxicity and human toxicity. As a result, serious delays affected the recognition of methylmercury as a cause of serious human poisonings in Minamata, Japan. Developmental neurotoxicity was first reported in 1952, but despite accumulating evidence, the vulnerability of the developing nervous system was not taken into account in risk assessment internationally until approximately 50 years later. Imprecision in exposure assessment and other forms of uncertainty tended to cause an underestimation of methylmercury toxicity and repeatedly led to calls for more research rather than prevention. Conclusions Coupled with legal and political rigidity that demanded convincing documentation before considering prevention and compensation, types of uncertainty that are common in environmental research delayed the scientific consensus and were used as an excuse for deferring corrective action. Symptoms of methylmercury toxicity, such as tunnel vision, forgetfulness, and lack of coordination, also seemed to affect environmental health research and its interpretation.
Determinants of Aortic Stiffness: 16-Year Follow-Up of the Whitehall II Study

Background Aortic stiffness is a strong predictor of cardiovascular disease endpoints. Cross-sectional studies have shown associations of various cardiovascular risk factors with aortic pulse wave velocity, a measure of aortic stiffness, but the long-term impact of these factors on aortic stiffness is unknown. Methods In 3,769 men and women from the Whitehall II cohort, a wide range of traditional and novel cardiovascular risk factors were determined at baseline (1991–1993) and aortic pulse wave velocity was measured at follow-up (2007–2009). The prospective associations between each baseline risk factor and aortic pulse wave velocity at follow-up were assessed through sex stratified linear regression analysis adjusted for relevant confounders. Missing data on baseline determinants were imputed using the Multivariate Imputation by Chained Equations. Results Among men, the strongest predictors were waist circumference, waist-hip ratio, heart rate and interleukin 1 receptor antagonist, and among women, adiponectin, triglycerides, pulse pressure and waist-hip ratio. The impact of 10 centimeter increase in waist circumference on aortic pulse wave velocity was twice as large for men compared with women (men: 0.40 m/s (95%-CI: 0.24;0.56); women: 0.17 m/s (95%-CI: −0.01;0.35)), whereas the opposite was true for the impact of a two-fold increase in adiponectin (men: −0.30 m/s (95%-CI: −0.51;−0.10); women: 0.61 m/s (95%-CI: −0.86;−0.35)). Conclusion In this large prospective study, central obesity was a strong predictor of aortic stiffness. Additionally, heart rate in men and adiponectin in women predicted aortic pulse wave velocity suggesting that strategies to prevent aortic stiffening should be focused differently by sex.