Miracle-dz/UniFAR-FTUs huggingface dataset:
Multiple scattering reduction in instantaneous gas phase phosphor thermometry: applications with dispersed seeding

In this study the structured laser illumination planar imaging (SLIPI) technique is combined with gas phase phosphor thermometry to measure quasi-instantaneously two-dimensional temperature fields with reduced bias from multiple scattering. Different reconstruction strategies are implemented, evaluated and compared, including a two-pulse and one-pulse SLIPI approach. A gradient-based threshold algorithm for particle detection is applied to conventional planar light sheet imaging as an alternative to reduce the bias caused by multiple scattering in seeding-free regions. As a demonstration, measurements are performed in a canonical flow configuration, consisting of a heated, turbulent, air jet surrounded by an ambient co-flow. Both air flows are seeded with the thermographic phosphor BaMgAl10O17:Eu2+. Conventional light sheet imaging in the context of gas phase phosphor thermometry suffers from multiple scattering causing a significant temperature bias and low temperature sensitivity. Applying the gradient threshold algorithm removes areas without any seeding particles which improves accuracy, precision and temperature sensitivity. However, multiple scattering influences are still present and may cause an increasing bias particularly for higher seeding density. One pulse (1p) SLIPI exhibits high accuracy at intermediate precision. Multiply scattered luminescence is not fully removed and spatial resolution is lowered. Two pulse (2p) SLIPI is recommended for high temperature sensitivity and accuracy, removing impact of multiple scattering furthermost. However, 2p-SLIPI exhibits reduced temperature precision.
Allometric growth and adaptive value of exaggerated body parts in the larvae of Gratiana spadicea (Klug) (Coleoptera: Chrysomelidae)

1. Larvae of tortoise beetles present exaggerated body parts in association with an abdominal shield, which is made of faeces and exuviae that are deposited on the urogomphi throughout ontogeny. Growth trajectories and scaling relationships of these functional structures associated with the shield, if any, are unknown.
Energy expenditure in stroke subjects walking with a carbon composite ankle foot orthosis.

OBJECTIVE To measure walking speed and energy cost in patients with prior stroke with and without a carbon composite ankle foot orthosis. DESIGN Within-group comparisons of 2 walking conditions. PARTICIPANTS Convenience sample of 10 hemiparetic patients with a stroke at least 6 months earlier (average age 52 years) habituated to a carbon composite ankle foot orthosis. METHODS Subjects walked on a treadmill at self-selected speed both with and without ankle foot orthosis for 5 minutes on each occasion. Energy expenditure was measured by breath-by-breath analysis and electrocardiography. Main outcome measures were walking speed, oxygen consumption, heart rate and energy cost per metre. RESULTS Walking speed: without ankle foot orthosis 0.27 (SEM +/- 0.03) m/s, with 0.34 (+/- 0.06) m/s, difference 20%. Oxygen consumption: without ankle foot orthosis 8.6 (+/- 0.4) ml/kg/min, with 8.8 (+/- 0.5) ml/kg/min. Energy cost: without ankle foot orthosis 0.58 (+/- 0.07) ml/kg/m, with 0.51 (+/- 0.06) ml/kg/m, difference 12%. CONCLUSION Use of a carbon composite ankle foot orthosis in patients with stroke may increase speed and decrease energy cost during walking.
Evolution and Use of Dynamic Transmission Models for Measles and Rubella Risk and Policy Analysis

The devastation caused by periodic measles outbreaks motivated efforts over more than a century to mathematically model measles disease and transmission. Following the identification of rubella, which similarly presents with fever and rash and causes congenital rubella syndrome (CRS) in infants born to women first infected with rubella early in pregnancy, modelers also began to characterize rubella disease and transmission. Despite the relatively large literature, no comprehensive review to date provides an overview of dynamic transmission models for measles and rubella developed to support risk and policy analysis. This systematic review of the literature identifies quantitative measles and/or rubella dynamic transmission models and characterizes key insights relevant for prospective modeling efforts. Overall, measles and rubella represent some of the relatively simplest viruses to model due to their ability to impact only humans and the apparent life‐long immunity that follows survival of infection and/or protection by vaccination, although complexities arise due to maternal antibodies and heterogeneity in mixing and some models considered potential waning immunity and reinfection. This review finds significant underreporting of measles and rubella infections and widespread recognition of the importance of achieving and maintaining high population immunity to stop and prevent measles and rubella transmission. The significantly lower transmissibility of rubella compared to measles implies that all countries could eliminate rubella and CRS by using combination of measles‐ and rubella‐containing vaccines (MRCVs) as they strive to meet regional measles elimination goals, which leads to the recommendation of changing the formulation of national measles‐containing vaccines from measles only to MRCV as the standard of care.
DETRAINING IN THE OLDER ADULT: EFFECTS OF PRIOR TRAINING INTENSITY ON STRENGTH RETENTION

In this study, we assessed the influence of training intensity on strength retention and loss incurred during detraining in older adults. In a previous study, untrained seniors (age = 71.0 ± 5.0; n = 61) were randomly divided into 3 exercise groups and 1 control group. Exercise groups trained 2 days per week for 18 weeks with equivalent volumes and acute program variables but intensities of 2 X 15 repetitions maximum (RM), 3 X 9RM, or 4 X 6RM. Thirty of the original training subjects (age 71.5 ± 5.2 years) participated in a 20-week detraining period. A 1RM for 8 exercises was obtained pre- and posttraining and at 6 and 20 weeks of detraining. The total of 1RM for the 8 exercises served as the dependent variable. Analysis of variance procedures demonstrated significant increases in strength with training (44–51%; p > 0.05), but no group effect. All training groups demonstrated significant strength decreases at both 6 and 20 weeks of detraining independent of prior training intensity (all group average 4.5% at 6 weeks and 13.5% at 20 weeks; p > 0.04). However, total-body strength was significantly greater than pretraining values after the detraining period (all group average 82% at 6 weeks and 49% at 20 weeks; p > 0.001). The results suggest that when older adults participate in progressive resistance exercise for 18 weeks, then stop resistance training (i.e., detrain), strength losses occur at both 6 and 20 weeks of detraining independent of prior resistance training intensity. However, despite the strength losses, significant levels of strength are retained even after 20 weeks of detraining. The results have important implications for resistance-trained older adults who could undergo planned or unplanned training interruptions of up to 5 months.
Discriminative Features Reconstruction Network for Semantic Segmentation

Thanks to the development of convolutional neural networks (CNNs), researchers have proposed lots of effective semantic segmentation models. However, there are still two problems disturbing researchers, one of which is objects misidentification on the image level and another one is poor performance on details, especially the boundary of objects. To tackle these two problems, we propose Discriminative Features Reconstruction Network (DFR) containing two modules: Second-order Pyramid Features Reconstruction Module (SPFR) and Second-order Boundary Attention Module (SBA). Specifically, SPFR fuses different scales features to gain pyramid receptive field. Besides, SPFR extracts second-order statistics data to retrieve more discriminative features. Furthermore, we put forward SBA that is helpful to refine the segmentation results. On SBA, low-level features recover localization details under the high-level feature guidance. Our DFR achieves state-of-the-art performance on PASCAL VOC 2012 dataset with mIoU accuracy 81.1% without pre-training COCO dataset and post-processing.1
Phospholipase Cγ Activation Drives Increased Production of Autotaxin in Endothelial Cells and Lysophosphatidic Acid-Dependent Regression

ABSTRACT We previously reported that vascular endothelial growth factor (VEGF)-dependent activation of phospholipase Cγ1 (PLCγ) regulated tube stability by competing with phosphoinositide 3-kinase (PI3K) for their common substrate. Here we describe an additional mechanism by which PLCγ promoted regression of tubes and blood vessels. Namely, it increased the level of autotaxin (ATX), which is a secreted form of lysophospholipase D that produces lysophosphatidic acid (LPA). LPA promoted motility of endothelial cells, leading to disorganization/regression of tubes in vitro. Furthermore, mice that under- or overexpressed members of this intrinsic destabilization pathway showed either delayed or accelerated, respectively, regression of blood vessels. We conclude that endothelial cells can be instructed to engage a PLCγ-dependent intrinsic destabilization pathway that results in the production of soluble regression factors such as ATX and LPA. These findings are likely to potentiate ongoing efforts to prevent, manage, and eradicate numerous angiogenesis-based diseases such as proliferative diabetic retinopathy and solid tumors.
Hypothyroidism in Carcinoma of the Tongue with Adjuvant Treatment

Objective The objective of this study was to evaluate the incidence of hypothyroidism with adjuvant treatment in oral tongue carcinoma patients treated primarily with surgery. Materials and methods A retrospective review was carried out to analyze hypothyroidism incidence and its relation to adjuvant treatment (radiation/radio-chemotherapy) in oral tongue carcinoma after the primary surgical ablation and neck dissection. Hypothyroidism was analyzed in relation with dose of radiation, gender, and adjuvant treatment modality. Results The study analyzed the patients who were treated between January 2012 and June 2015. Among 705 patients with carcinoma of the tongue treated primarily with wide local excision and neck dissection, 383 received adjuvant treatment. A total of 215 patients received radiation, and 168 received concurrent radio-chemotherapy. Of 378 patients, 78 developed hypothyroidism during follow-up: 27 patients received concurrent radio-chemotherapy, and the remaining 51 received only radiation. Lower neck received 40–48 Gy in 2 patients, 50 Gy in 74 patients, and 60–70 Gy and concurrent radio-chemotherapy in 27 patients. Median follow-up was 32 months. Hypothyroidism occurred in 21.5% of patients with squamous cell carcinoma of the oral tongue. The minimum period to develop hypothyroidism was 3 months in this study. Gender and adjuvant treatment were not found to be significant for the incidence of hypothyroidism. Conclusions A significant number of patients with carcinoma of the tongue who receive adjuvant treatment will develop hypothyroidism, hence frequent monitoring of thyroid function is advised during follow-up.
Prior Exposure to Live Mycobacterium bovis BCG Decreases Cryptococcus neoformans-Induced Lung Eosinophilia in a Gamma Interferon-Dependent Manner

ABSTRACT Some common childhood infections appear to prevent the development of atopy and asthma. In some Mycobacterium bovis BCG-vaccinated populations, strong delayed-type hypersensitivity responses to mycobacterial antigens are associated with a reduced risk of atopy. Although BCG exposure decreases allergen-induced lung eosinophilia in animal models, little attention has been given to the effect of immunity to BCG on responses against live pathogens. We used the murine Cryptococcus neoformans infection model to investigate whether prior BCG infection can alter such responses. The present study shows that persistent pulmonary BCG infection of C57BL/6 mice induced an increase in gamma interferon, a reduction in interleukin-5, and a decrease in lung eosinophilia during subsequent Cryptococcus infection. This effect was long lasting, depended on the presence of live bacteria, and required persistence of mycobacterial infection in the lung. Reduction of eosinophilia was less prominent after infection with a mutant BCG strain (ΔhspR), which was rapidly cleared from the lungs. These observations have important implications for the development of vaccines designed to prevent Th2-mediated disease and indicate that prior lung BCG vaccination can alter the pattern of subsequent host inflammation.
Dividing Wall Distillation Columns : Optimization and Control Properties

The optimal design of dividing wall columns is a non-linear and multivariable problem, and the objective function used as optimization criterion is generally non-convex with several local optimums. Considering this fact, in this paper, we studied the design of dividing wall columns using as a design tool, a multi-objective genetic algorithm with restrictions, written in Matlab and using the process simulator Aspen Plus for the evaluation of the objective function. Numerical performance of this method has been tested in the design of columns with one or two dividing walls and with several mixtures to test the effect of the relative volatilities of the feed mixtures on energy consumption, second law efficiency, total annual cost, and theoretical control properties. In general, the numerical performance shows that this method appears to be robust and suitable for the design of sequences with dividing walls.
Atmospheric ammonia variability and link with PM formation: a case study over the Paris area

Abstract. The Paris megacity experiences frequent particulate matter (PM2.5, PM with a diameter less than 2.5 μm) pollution episodes in springtime (March–April). At this time of the year, large parts of the particles consist of ammonium sulfate and nitrate which are formed from ammonia (NH3) released during fertilizer spreading practices and transported from the surrounding areas to Paris. There is still limited knowledge on the emission sources around Paris, their magnitude and seasonality. Using space-borne NH3 observation records of 10-years (2008–2017) and 5-years (2013–2017) provided by the Infrared Atmospheric Sounding Interferometer (IASI) and the Cross-Track Infrared Sounder (CrIS) instrument, regional pattern of NH3 variabilities (seasonal and inter-annual) are derived. Observations reveal identical high seasonal variabilities with three major NH3 hot spots found from March to August. The high inter-annual variability is discussed with respect to atmospheric total precipitation and temperature. A detailed analysis of the seasonal cycle is performed using both IASI and the CrIS instrument data, together with outputs from the CHIMERE atmospheric model. For months of high NH3 concentrations (March to August) the CHIMERE model shows good correspondence with correlation slopes of 0.98 and 0.71 when comparing with IASI and CrIS, respectively. It is found that the model is only able to reproduce half of the observed atmospheric temporal NH3 variability in the domain. In term of spatial variability, the CHIMERE monthly NH3 concentrations in springtime show a slight underrepresentation over Belgium and the United-Kingdom and overrepresentation in agricultural areas in the French Brittany/Pays de la Loire and Plateau du Jura region, as well as in the north part of Switzerland. Using HYSPLIT cluster analysis of back-trajectories, we show that NH3 total columns measured in spring over Paris are enhanced when air masses are originated from the Northeast (e. g., Netherlands and Belgium), highlighting the long-range transport importance on the NH3 budget over Paris. Finally, we quantify the key meteorological parameters driving the specific conditions important for the PM2.5 formation from NH3 in the Ile-de-France region in springtime. Data-driven results based on surface PM2.5 measurements from the Airparif network and IASI NH3 observations show that a combination of the factors, e. g. a low boundary layer of ~500 m, a relatively low temperature of 5 °C and a high relative humidity of 70 %, contributes to favor PM2.5 and NH3 correlation.
Success of the peritoneal dialysis programme in Hong Kong.

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Subjective assessment of quality of sleep in chronic obstructive pulmonary disease patient and its relationship with associated depression

Background: The quality of sleep in chronic obstructive pulmonary disease (COPD) patient from India has not been studied. Aim of this study was evaluation of subjective assessment of sleep quality in stable COPD patients and its relationship with associated depression. Materials and Methods: Forty clinically stable COPD patients were recruited from outpatient department and their disease status was classified as per Global Initiative for Chronic Obstructive Lung Disease guideline. Presence of depression was assessed by administering Patient Health Questionnaire (PHQ)-9 and subjective quality of sleep was measured by Pittsburgh Sleep Quality Index (PSQI). Results: All study subjects were male and mean age of study population was 62.2 ± 9.2 years, 12 patients (30%) in stage II, 19 patients (47.5%) in stage III and 9 patients (22.5%) in stage IV were enrolled. All subjects had poor sleep quality with the median global Pittsburgh Sleep Quality Index score 11. PHQ-9 score was significantly correlated with daytime function and global PSQI score (P<0.01). No correlation of global PSQI score with severity of COPD was observed. Conclusion: The prevalence of poor sleep quality among COPD patients is high. Irrespective of severity of airflow obstruction, the presence of depression in COPD is a risk factor for poor sleep quality.
Review of evidence for use of antidepressants in bipolar depression.

OBJECTIVE Depressive episodes predominate over the course of bipolar disorder and cause considerable functional impairment. Antidepressants are frequently prescribed in the treatment of bipolar depression, despite concerns about efficacy and risk of switching to mania. This review provides a critical examination of the evidence for and against the use of antidepressants in bipolar depression. DATA SOURCES English-language peer-reviewed literature and evidence-based guidelines published between January 1, 1980, and March 2014, were identified using PubMed, MEDLINE, PsycINFO/PsycLIT, and EMBASE. All searches contained the terms antidepressants, bipolar depression, depressive episodes in bipolar disorder, and treatment guidelines for bipolar depression. Meta-analyses, randomized controlled trials, systematic reviews, and practice guidelines were included. Bibliographies from these publications were used to identify additional articles of interest. DATA EXTRACTION Studies involving treatment of bipolar depression with antidepressant monotherapy, adjunctive use of antidepressant with a mood stabilizer, and meta-analysis of such studies combined were reviewed. CONCLUSIONS The body of evidence on the use of antidepressant monotherapy to treat patients with bipolar depression is contentious, but the recommendations from evidence-based guidelines do not support antidepressant monotherapy for bipolar depression. Only when mood stabilizer or atypical antipsychotic monotherapy has failed should adjunctive treatment with an antidepressant be considered.
The Penalty of a Long, Hot Summer. Photosynthetic Acclimation to High CO2 and Continuous Light in “Living Fossil” Conifers1

Deciduous forests covered the ice-free polar regions 280 to 40 million years ago under warm “greenhouse” climates and high atmospheric pCO2. Their deciduous habit is frequently interpreted as an adaptation for minimizing carbon losses during winter, but experiments with “living fossils” in a simulated warm polar environment refute this explanation. Measured carbon losses through leaf abscission of deciduous trees are significantly greater than losses through winter respiration in evergreens, yet annual rates of primary productivity are similar in all species. Here, we investigate mechanisms underlying this apparent paradox by measuring the seasonal patterns of leaf photosynthesis (A) under pCO2 enrichment in the same trees. During spring, A increased significantly in coastal redwood (Sequoia sempervirens), dawn redwood (Metasequoia glyptostroboides), and swamp cypress (Taxodium distichum) at an elevated pCO2 of 80 Pa compared with controls at 40 Pa. However, strong acclimation in Rubisco carboxylation capacity (Vc,max) completely offset the CO2 response of A in all species by the end of 6 weeks of continuous illumination in the simulated polar summer. Further measurements demonstrated the temporary nature of acclimation, with increases in Vc,max during autumn restoring the CO2 sensitivity of A. Contrary to expectations, the acclimation of Vc,max was not always accompanied by accumulation of leaf carbohydrates, but was associated with a decline in leaf nitrogen in summer, suggesting an alteration of the balance in plant sources and sinks for carbon and nitrogen. Preliminary calculations using A indicated that winter carbon losses through deciduous leaf abscission and respiration were recovered by 10 to 25 d of canopy carbon fixation during summer, thereby explaining the productivity paradox.