Miracle-dz/UniFAR-FTUs huggingface dataset:
Money and indeterminacy over an infinite horizon 1

Money provides liquidity services through a cash-in-advance constraint. The exchange of commodities and assets extends over an infinite horizon under uncertainty and a complete asset market. Monetary policy sets the path of rates of interest and accommodates the demand for balances. Competitive equilibria exist. But, for a fixed path of rates of interest, there is a non-trivial multiplicity of equilibrium paths of prices of commodities. Determinacy requires that, subject to no-arbitrage and in addition to rates of interest, the prices of state-contingent revenues be set.
Efficient and Anonymous Two-Factor User Authentication in Wireless Sensor Networks: Achieving User Anonymity with Lightweight Sensor Computation

A smart-card-based user authentication scheme for wireless sensor networks (hereafter referred to as a SCA-WSN scheme) is designed to ensure that only users who possess both a smart card and the corresponding password are allowed to gain access to sensor data and their transmissions. Despite many research efforts in recent years, it remains a challenging task to design an efficient SCA-WSN scheme that achieves user anonymity. The majority of published SCA-WSN schemes use only lightweight cryptographic techniques (rather than public-key cryptographic techniques) for the sake of efficiency, and have been demonstrated to suffer from the inability to provide user anonymity. Some schemes employ elliptic curve cryptography for better security but require sensors with strict resource constraints to perform computationally expensive scalar-point multiplications; despite the increased computational requirements, these schemes do not provide user anonymity. In this paper, we present a new SCA-WSN scheme that not only achieves user anonymity but also is efficient in terms of the computation loads for sensors. Our scheme employs elliptic curve cryptography but restricts its use only to anonymous user-to-gateway authentication, thereby allowing sensors to perform only lightweight cryptographic operations. Our scheme also enjoys provable security in a formal model extended from the widely accepted Bellare-Pointcheval-Rogaway (2000) model to capture the user anonymity property and various SCA-WSN specific attacks (e.g., stolen smart card attacks, node capture attacks, privileged insider attacks, and stolen verifier attacks).
Gender differences in reasons for frequent blog posting

Purpose – This paper aims to improve understanding of what motivates individual blog owners to post information frequently on weblogs, and whether gender affects those motivations.Design/methodology/approach – The authors propose a model incorporating three key determinants of the intention to update weblogs: self‐expression; subjective norms; and personal outcome expectations. These were based on Social Cognitive Theory. An empirical study involving 525 subjects was conducted to test this model.Findings – The results indicate that subjective norms have a stronger effect on the intention than personal outcome expectations or self‐expression. Additionally, women's intention was strongly influenced by self‐expression while men's intention was strongly influenced by personal outcome expectations of using weblogs.Research limitations/implications – The authors verified the effects of subjective norms, personal outcome expectations and self‐expression on the intentions of weblog owners. The research found that.
The Regulation and Activation of Ciliary Neurotrophic Factor Signaling Proteins in Adipocytes*

Ciliary neurotrophic factor (CNTF) is primarily known for its roles as a lesion factor released by the ruptured glial cells that prevent neuronal degeneration. However, CNTF has also been shown to cause weight loss in a variety of rodent models of obesity/type II diabetes, whereas a modified form also causes weight loss in humans. CNTF administration can correct or improve hyperinsulinemia, hyperphagia, and hyperlipidemia associated with these models of obesity. In order to investigate the effects of CNTF on fat cells, we examined the expression of CNTF receptor complex proteins (LIFR, gp130, and CNTFRα) during adipocyte differentiation and the effects of CNTF on STAT, Akt, and MAPK activation. We also examined the ability of CNTF to regulate the expression of adipocyte transcription factors and other adipogenic proteins. Our studies clearly demonstrate that the expression of two of the three CNTF receptor complex components, CNTFRα and LIFR, decreases during adipocyte differentiation. In contrast, gp130 expression is relatively unaffected by differentiation. In addition, preadipocytes are more sensitive to CNTF treatment than adipocytes, as judged by both STAT 3 and Akt activation. Despite decreased levels of CNTFRα expression in fully differentiated 3T3-L1 adipocytes, CNTF treatment of these cells resulted in a time-dependent activation of STAT 3. Chronic treatment of adipocytes resulted in a substantial decrease in fatty-acid synthase and a notable decline in SREBP-1 levels but had no effect on the expression of peroxisome proliferator-activated receptor γ, acrp30, adipocyte-expressed STAT proteins, or C/EBPα. However, CNTF resulted in a significant increase in IRS-1 expression. CNTFRα receptor expression was substantially induced in the fat pads of four rodent models of obesity/type II diabetes as compared with lean littermates. Moreover, we demonstrated that CNTF can activate STAT 3 in adipose tissue and skeletal muscle in vivo. In summary, CNTF affects adipocyte gene expression, and the specific receptor for this cytokine is induced in rodent models of obesity/type II diabetes.
Comprehensive gene and taxon coverage elucidates radiation patterns in moths and butterflies

Lepidoptera (butterflies and moths) represent one of the most diverse animals groups. Yet, the phylogeny of advanced ditrysian Lepidoptera, accounting for about 99 per cent of lepidopteran species, has remained largely unresolved. We report a rigorous and comprehensive analysis of lepidopteran affinities. We performed phylogenetic analyses of 350 taxa representing nearly 90 per cent of lepidopteran families. We found Ditrysia to be a monophyletic taxon with the clade Tischerioidea + Palaephatoidea being the sister group of it. No support for the monophyly of the proposed major internested ditrysian clades, Apoditrysia, Obtectomera and Macrolepidoptera, was found as currently defined, but each of these is supported with some modification. The monophyly or near-monophyly of most previously identified lepidopteran superfamilies is reinforced, but several species-rich superfamilies were found to be para- or polyphyletic. Butterflies were found to be more closely related to ‘microlepidopteran’ groups of moths rather than the clade Macrolepidoptera, where they have traditionally been placed. There is support for the monophyly of Macrolepidoptera when butterflies and Calliduloidea are excluded. The data suggest that the generally short diverging nodes between major groupings in basal non-tineoid Ditrysia are owing to their rapid radiation, presumably in correlation with the radiation of flowering plants.
Improving Phrase-Based Translation via Word Alignments from Stochastic Inversion Transduction Grammars

We argue that learning word alignments through a compositionally-structured, joint process yields higher phrase-based translation accuracy than the conventional heuristic of intersecting conditional models. Flawed word alignments can lead to flawed phrase translations that damage translation accuracy. Yet the IBM word alignments usually used today are known to be flawed, in large part because IBM models (1) model reordering by allowing unrestricted movement of words, rather than constrained movement of compositional units, and therefore must (2) attempt to compensate via directed, asymmetric distortion and fertility models. The conventional heuristics for attempting to recover from the resulting alignment errors involve estimating two directed models in opposite directions and then intersecting their alignments -- to make up for the fact that, in reality, word alignment is an inherently joint relation. A natural alternative is provided by Inversion Transduction Grammars, which estimate the joint word alignment relation directly, eliminating the need for any of the conventional heuristics. We show that this alignment ultimately produces superior translation accuracy on BLEU, NIST, and METEOR metrics over three distinct language pairs.
Interferon‐Related Transcriptome Alterations in the Cerebrospinal Fluid Cells of Aicardi‐Goutières Patients †

Aicardi–Goutières syndrome (AGS) is a rare interferon (IFN)‐related encephalopathy with onset during the first year of life. AGS, is clinically characterized by progressive microcephaly, bilateral basal ganglia calcification, cerebral atrophy, cerebrospinal fluid (CSF), lymphocytosis, delayed development of psychomotor abilities with pyramidal–extrapyramidal syndrome and mimics congenital viral infections. Microarray analysis examining the expression of 18 880 human genes has been applied to the CSF lymphocytes of 20 AGS cases (age 4.5 ± 4.4 years, mean ± standard deviation) characterized by high IFN‐alpha levels in CSF and 20 matched controls (age 4.4 ± 4.3 years, mean ± standard deviation). Gene‐expression data reveal significant differences between AGS cases and controls for all controls and 18 AGS cases. The two AGS cases unclassified as compared with controls were both older than 7 years. AGS cases presented upregulation of genes involved in IFN‐dependent pathways and lymphocyte functions, paralleled by the downregulation of genes encoding for angiopoietic activities. The cystatin F and DNAJ genes, having a negative feedback on IFN pathways, underwent a progressive age‐related increase in their expression. These gene‐expression signature parallels a progressive attenuation of clinical symptoms with age. Obtained results provide evidence that exposure to IFN‐alpha is harmful for developing brain.
Respiratory Viral Infections in Infants: Causes, Clinical Symptoms, Virology, and Immunology

SUMMARY In global terms, respiratory viral infection is a major cause of morbidity and mortality. Infancy, in particular, is a time of increased disease susceptibility and severity. Early-life viral infection causes acute illness and can be associated with the development of wheezing and asthma in later life. The most commonly detected viruses are respiratory syncytial virus (RSV), rhinovirus (RV), and influenza virus. In this review we explore the complete picture from epidemiology and virology to clinical impact and immunology. Three striking aspects emerge. The first is the degree of similarity: although the infecting viruses are all different, the clinical outcome, viral evasion strategies, immune response, and long-term sequelae share many common features. The second is the interplay between the infant immune system and viral infection: the immaturity of the infant immune system alters the outcome of viral infection, but at the same time, viral infection shapes the development of the infant immune system and its future responses. Finally, both the virus and the immune response contribute to damage to the lungs and subsequent disease, and therefore, any prevention or treatment needs to address both of these factors.
Continuous validation of load test suites

Ultra-Large-Scale (ULS) systems face continuously evolving field workloads in terms of activated/disabled feature sets, varying usage patterns and changing deployment configurations. These evolving workloads often have a large impact, on the performance of a ULS system. Hence, continuous load testing is critical to ensuring the error-free operation of such systems. A common challenge facing performance analysts is to validate if a load test closely resembles the current field workloads. Such validation may be performed by comparing execution logs from the load test and the field. However, the size and unstructured nature of execution logs makes such a comparison unfeasible without automated support. In this paper, we propose an automated approach to validate whether a load test resembles the field workload and, if not, determines how they differ by compare execution logs from a load test and the field. Performance analysts can then update their load test cases to eliminate such differences, hence creating more realistic load test cases. We perform three case studies on two large systems: one open-source system and one enterprise system. Our approach identifies differences between load tests and the field with a precision of >75% compared to only >16% for the state-of-the-practice.
Nitric Oxide-Dependent Production of cGMP Supports the Survival of Rat Embryonic Motor Neurons Cultured with Brain-Derived Neurotrophic Factor

Trophic factor deprivation induces neuronal nitric oxide synthase (NOS) and apoptosis of rat embryonic motor neurons in culture. We report here that motor neurons constitutively express endothelial NOS that helps support the survival of motor neurons cultured with brain-derived neurotrophic factor (BDNF) by activating the nitric oxide-dependent soluble guanylate cyclase. Exposure of BDNF-treated motor neurons to nitro-l-arginine methyl ester (l-NAME) decreased cell survival 40–50% 24 hr after plating. Both low steady-state concentrations of exogenous nitric oxide (<0.1 μm) and cGMP analogs protected BDNF-treated motor neurons from death induced by l-NAME. Equivalent concentrations of cAMP analogs did not affect cell survival. Inhibition of nitric oxide-sensitive guanylate cyclase with 2 μm1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) reduced the survival of BDNF-treated motor neurons by 35%. cGMP analogs also protected from ODQ-induced motor neuron death, whereas exogenous nitric oxide did not. In all cases, cell death was prevented with caspase inhibitors. Our results suggest that nitric oxide-stimulated cGMP synthesis helps to prevent apoptosis in BDNF-treated motor neurons.
Projective testing of diurnal collective emotion

Projective tests are personality tests that reveal individuals' emotions (e.g., Rorschach inkblot test). Unlike direct question-based tests, projective tests rely on ambiguous stimuli to evoke responses from individuals. In this paper we develop one such test, designed to be delivered automatically, anonymously and to a large community through public displays. Our work makes a number of contributions. First, we develop and validate in controlled conditions a quantitative projective test that can reveal emotions. Second, we demonstrate that this test can be deployed on a large scale longitudinally: we present a four-week deployment in our university's public spaces where 1431 tests were completed anonymously by passers-by. Third, our results reveal strong diurnal rhythms of emotion consistent with results we obtained independently using the Day Reconstruction Method (DRM), literature on affect, well-being, and our understanding of our university's daily routine.
Cognitive impairment and stroke in elderly patients

We reviewed current knowledge about the interaction between stroke and vascular risk factors and the development of cognitive impairment and dementia. Stroke is increasingly recognized as an important cause of cognitive problems and has been implicated in the development of both Alzheimer’s disease and vascular dementia. The prevalence of cognitive impairment after stroke is high, and their combined effects significantly increase the cost of care and health resource utilization, with reflections on hospital readmissions and increased mortality rates. There is also substantial evidence that vascular risk factors (such as hypertension, diabetes, obesity, dyslipidemia, and tobacco smoking) are independently associated with an increased risk of cognitive decline and dementia. Thus, a successful management of these factors, as well as optimal acute stroke management, might have a great impact on the development of cognitive impairment. Notwithstanding, the pathological link between cognitive impairment, stroke, and vascular risk factors is complex and still partially unclear so that further studies are needed to better elucidate the boundaries of this relationship. Many specific pharmacological treatments, including anticholinergic drugs and antihypertensive medications, and nonpharmacological approaches, such as diet, cognitive rehabilitation, and physical activity, have been studied for patients with vascular cognitive impairment, but the optimal care is still far away. Meanwhile, according to the most recent knowledge, optimal stroke care should also include cognitive assessment in the short and long term, and great efforts should be oriented toward a multidisciplinary approach, including quality-of-life assessment and support of caregivers.
The NOD-Like Receptor Signalling Pathway in Helicobacter pylori Infection and Related Gastric Cancer: A Case-Control Study and Gene Expression Analyses

Background Currently, it is well established that cancer arises in chronically inflamed tissue. A number of NOD-like receptors (NLRs) form inflammasomes, intracellular multiprotein complexes critical for generating mature pro-inflammatory cytokines (IL-1β and IL-18). As chronic inflammation of the gastric mucosa is a consequence of Helicobacter pylori infection, we investigated the role of genetic polymorphisms and expression of genes involved in the NLR signalling pathway in H. pylori infection and related gastric cancer (GC). Materials and Methods Fifty-one genetic polymorphisms were genotyped in 310 ethnic Chinese (87 non-cardia GC cases and 223 controls with functional dyspepsia). In addition, gene expression of 84 molecules involved in the NLR signalling pathway was assessed in THP-1 cells challenged with two H. pylori strains, GC026 (GC) and 26695 (gastritis). Results CARD8-rs11672725, NLRP3-rs10754558, NLRP3-rs4612666, NLRP12-rs199475867 and NLRX1-rs10790286 showed significant associations with GC. On multivariate analysis, CARD8-rs11672725 remained a risk factor (OR: 4.80, 95% CI: 1.39–16.58). Further, NLRP12-rs2866112 increased the risk of H. pylori infection (OR: 2.13, 95% CI: 1.22–3.71). Statistical analyses assessing the joint effect of H. pylori infection and the selected polymorphisms revealed strong associations with GC (CARD8, NLRP3, CASP1 and NLRP12 polymorphisms). In gene expression analyses, five genes encoding NLRs were significantly regulated in H. pylori-challenged cells (NLRC4, NLRC5, NLRP9, NLRP12 and NLRX1). Interestingly, persistent up-regulation of NFKB1 with simultaneous down-regulation of NLRP12 and NLRX1 was observed in H. pylori GC026-challenged cells. Further, NF-κB target genes encoding pro-inflammatory cytokines, chemokines and molecules involved in carcinogenesis were markedly up-regulated in H. pylori GC026-challenged cells. Conclusions Novel associations between polymorphisms in the NLR signalling pathway (CARD8, NLRP3, NLRP12, NLRX1, and CASP1) and GC were identified in Chinese individuals. Our genetic polymorphisms and gene expression results highlight the relevance of the NLR signalling pathway in gastric carcinogenesis and its close interaction with NF-κB.
Simple Clinical Risk Score Identifies Patients with Serrated Polyps in Routine Practice

Large, proximal, or dysplastic (LPD) serrated polyps (SP) need accurate endoscopic recognition and removal as these might progress to colorectal cancer. Herewith, we examined the risk factors for having ≥1 LPD SP. We developed and validated a simple SP risk score as a potential tool for improving their detection. We reviewed clinical, endoscopic, and histologic features of serrated polyps in a study of patients undergoing elective colonoscopy (derivation cohort). A self-administered questionnaire was obtained. We conducted logistic regression analyses to identify independent risk factors for having ≥1 LPD SP and incorporated significant variables into a clinical score. We subsequently tested the performance of the SP score in a validation cohort. We examined 2,244 patients in the derivation and 2,402 patients in the validation cohort; 6.3% and 8.2% had ≥1 LPD SP, respectively. Independent risk factors for LPD SPs were age of more than 50 years [OR 2.2; 95% confidence interval (CI), 1.3–3.8; P = 0.004], personal history of serrated polyps (OR 2.6; 95% CI, 1.3–4.9; P = 0.005), current smoking (OR 2.2; 95% CI, 1.4–3.6; P = 0.001), and nondaily/no aspirin use (OR 1.8; 95% CI, 1.1–3.0; P = 0.016). In the validation cohort, a SP score ≥5 points was associated with a 3.0-fold increased odds for LPD SPs, compared with patients with a score <5 points. In the present study, age of more than 50 years, a personal history of serrated polyps, current smoking, and nondaily/no aspirin use were independent risk factors for having LPD SPs. The SP score might aid the endoscopist in the detection of such lesions. Cancer Prev Res; 6(8); 855–63. ©2013 AACR.
Weakly Almost Periodic Points and Some Chaotic Properties of Dynamical Systems

Let X be a compact metric space and f : X → X be a continuous map. In this paper, ergodic chaos and strongly ergodic chaos are introduced, and it is proven that f is strongly ergodically chaotic if f is transitive but not minimal and has a full measure center. In addition, some sufficient conditions for f to be Ruelle–Takens chaotic are presented. For instance, we prove that f is Ruelle–Takens chaotic if f is transitive and there exists a countable base of X such that for each i > 0, the meeting time set N(Ui, Ui) for Ui with respect to itself has lower density larger than .
Surface-modified MgO nanoparticle enhances the mechanical and direct-current electrical characteristics of polypropylene/polyolefin elastomer nanodielectrics

Polypropylene (PP)/polyolefin elastomer (POE) blends and MgO/PP/POE nanocomposites were fabricated by melt blending. The morphology, mechanical, and electrical properties of the nanocomposites were investigated. Scanning electron microscopy showed that the surface-modified MgO nanoparticles were well dispersed in the polymer matrix at low loadings of less than 3 phr. X-ray diffraction demonstrated that the crystalline phases of PP in the composites were changed and that the β phase significantly increased. An examination of the electrical properties revealed that the direct-current (dc) electric breakdown strength and space-charge suppression effect were remarkably improved by the introduction of the surface-modified MgO nanoparticles. In addition, obvious enhancements in the tensile modulus and strength were obtained as a result of the synergistic toughening of the POE and MgO nanoparticles. Thus, MgO/PP/POE nanocomposites with enhanced mechanical and electrical properties have great potential to be used as recyclable insulation materials for high-voltage dc cables with large transmission capacities and high operating temperatures. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 132, 42863.
PRACTI Replication

We present PRACTI, a new approach for large-scale replication. PRACTI systems can replicate or cache any subset of data on any node (Partial Replication), provide a broad range of consistency guarantees (Arbitrary Consistency), and permit any node to send information to any other node (Topology Independence). A PRACTI architecture yields two significant advantages. First, by providing all three PRACTI properties, it enables better trade-offs than existing mechanisms that support at most two of the three desirable properties. The PRACTI approach thus exposes new points in the design space for replication systems. Second, the flexibility of PRACTI protocols simplifies the design of replication systems by allowing a single architecture to subsume a broad range of existing systems and to reduce development costs for new ones. To illustrate both advantages, we use our PRACTI prototype to emulate existing server replication, client-server, and object replication systems and to implement novel policies that improve performance for mobile users, web edge servers, and grid computing by as much as an order of magnitude.