Miracle-dz/UniFAR-FTUs huggingface dataset:
A Systematic Review of Gender Differences in Mortality after Coronary Artery Bypass Graft Surgery and Percutaneous Coronary Interventions

Gender differences exist in outcomes, particularly early mortality, for percutaneous interventions (PCI) and coronary artery bypass graft surgery (CABG). Better understanding of this issue may target areas for improvement for all patients undergoing revascularization. Therefore, we summarized the evidence on gender differences in PCI and CABG outcomes, particularly early mortality, and mediators of this difference. Using the key terms “women” or “gender,” “revascularization,” “coronary artery bypass,” “angioplasty,” “stent,” and “coronary intervention,” we searched MEDLINE from 1985 to 2005 for all randomized controlled trials (RCTs) and registries reporting outcomes by gender. Bibliographies and the Web sites of cardiology conferences were also reviewed. The literature was examined to identify gender differences in outcomes and mediators of these differences. We identified 23 studies reporting outcomes by gender for CABG and 48 studies reporting outcomes by gender for PCI. The majority of studies noted greater in‐hospital mortality in women than in men, with mortality differences resolving with longer follow‐up. Early mortality differences were reduced but not consistently eliminated after adjustment for comorbidities, procedural characteristics, and body habitus. Power to detect gender differences after multivariate adjustment was limited by declining mortality rates and small sample size. Gender was an independent risk factor for complications after both CABG and PCI. Women experience greater complications and early mortality after revascularization. Future exploration is needed of gender differences in quality of care and benefit from combinations of stenting and antiplatelet, and anticoagulant medications in order to optimize treatment. Copyright © 2007 Wiley Periodicals, Inc.
Identification of Molecular Predictors of Response in a Study of Tipifarnib Treatment in Relapsed and Refractory Acute Myelogenous Leukemia

Purpose: Microarray technology was used to identify gene expression markers that predict response to the orally available farnesyltransferase inhibitor tipifarnib (Zarnestra, R115777) in acute myelogenous leukemia (AML). Experimental Design: Gene expression profiles from 58 bone marrow samples from a cohort of relapsed and refractory AML patients were analyzed on the Affymetrix U133A gene chip that contains ∼22,000 genes. Results: Supervised statistical analysis identified eight gene expression markers that could predict patient response to tipifarnib. The most robust gene was the lymphoid blast crisis oncogene (AKAP13), which predicted response with an overall accuracy of 63%. This gene provided a negative predictive value of 93% and a positive predictive value of 31% (increased from 18%). AKAP13 was overexpressed in patients who were resistant to tipifarnib. When overexpressed in the HL60 and THP1 cell lines, AKAP13 increased the resistance to tipifarnib by approximately 5- to 7-fold. Conclusion: Diagnostic gene expression signatures may be used to select a group of AML patients that might respond to tipifarnib.
Ethical Leadership: Not Everyone Responds Equally

ABSTRACT Theoretical frameworks associated with ethical leadership have not fully considered the nature of the leader–follower exchange, and, in addition, few studies have considered the impact of follower individual differences in reactions to ethical leadership. Our research extends the customary social exchange perspective of transactional and relational resources by accounting for the ideological resources (i.e., value-oriented principles) that can also imbue the leader–subordinate relationship. Second, differences in equity sensitivity are hypothesized to moderate the influence of ethical leadership on employee attachment to the organization. We predicted that the impact of ethical leadership on organizational commitment, job satisfaction, and organizational identification is greater for individuals with a more benevolent orientation. In Study 1 (N = 223), equity sensitivity moderated the influence of ethical leadership on organizational commitment and organizational identification. In Study 2 (N = 244), an interactive effect was found for the outcomes of organizational commitment and job satisfaction. We consider the theoretical implications of how and why ethical leadership influences follower attitudes and beliefs.
Analysis and Implementation of an Ajax-enabled Web Crawler

This paper analyzes a web crawler for the Web 2.0 network, which presents new challenges. A comprehensive overview on various programs and strategies is presented, which includes the design and realization of Ajax reptiles. Experimental verification indicates that an Ajax Crawler can effectively obtain Ajax dynamic pages. The proposed Ajax Crawler is then compared with common Ajax reptiles in terms of their download speeds.
3D FACE RECOGNITION USING PATCH GEODESIC DERIVATIVE PATTERN

In this paper, a novel Patch Geodesic Derivative Pattern (PGDP) describing the texture map of a face through its shape data is proposed. Geodesic adjusted textures are encoded into derivative patterns for similarity measurement between two 3D images with different pose and expression variations. An extensive experimental investigation is conducted using the publicly available Bosphorus and BU-3DFE databases covering face recognition under pose and expression changes. The performance of the proposed method is compared with the performance of the state-of-the-art benchmark approaches. The encouraging experimental results demonstrate that the proposed method is a new solution for 3D face recognition in single model databases.
A high-density integrated genetic linkage and radiation hybrid map of the laboratory rat.

The laboratory rat (Rattus norvegicus) is a key animal model for biomedical research. However, the genetic infrastructure required for connecting phenotype and genotype in the rat is currently incomplete. Here, we report the construction and integration of two genomic maps: a dense genetic linkage map of the rat and the first radiation hybrid (RH) map of the rat. The genetic map was constructed in two F2 intercrosses (SHRSP x BN and FHH x ACI), containing a total of 4736 simple sequence length polymorphism (SSLP) markers. Allele sizes for 4328 of the genetic markers were characterized in 48 of the most commonly used inbred strains. The RH map is a lod >/= 3 framework map, including 983 SSLPs, thereby allowing integration with markers on various genetic maps and with markers mapped on the RH panel. Together, the maps provide an integrated reference to >3000 genes and ESTs and >8500 genetic markers (5211 of our SSLPs and >3500 SSLPs developed by other groups). [Bihoreau et al. (1997); James and Tanigami, RHdb (http:www.ebi.ac.uk/RHdb/index.html); Wilder (http://www.nih.gov/niams/scientific/ratgbase); Serikawa et al. (1992); RATMAP server (http://ratmap.gen.gu.se)] RH maps (v. 2.0) have been posted on our web sites at http://goliath.ifrc. mcw.edu/LGR/index.html or http://curatools.curagen. com/ratmap. Both web sites provide an RH mapping server where investigators can localize their own RH vectors relative to this map. The raw data have been deposited in the RHdb database. Taken together, these maps provide the basic tools for rat genomics. The RH map provides the means to rapidly localize genetic markers, genes, and ESTs within the rat genome. These maps provide the basic tools for rat genomics. They will facilitate studies of multifactorial disease and functional genomics, allow construction of physical maps, and provide a scaffold for both directed and large-scale sequencing efforts and comparative genomics in this important experimental organism.
Practical aspects of the Moreau-Yosida regularization I : theoretical properties

When computing the innmal convolution of a convex function f with the squared norm, one obtains the so-called Moreau-Yosida regularization of f. Among other things, this function has a Lipschitzian gradient. We investigate some more of its properties, relevant for optimization. Our main result concerns second-order diierentiability and is as follows. Under assumptions that are quite reasonable in optimization, the Moreau-Yosida is twice diiferentiable if and only if f is twice diierentiable as well. In the course of our development, we give some results of general interest in convex analysis. In particular, we establish primal-dual relationship between the remainder terms in the rst-order development of a convex function and its conjugate. Aspects pratiques de la r egularis ee de Moreau-Yosida I: propri et es th eoriques R esum e : La r egular es ee de Moreau-Yosida d'une fonction convexe f est l'inf-convolution de f avec le carr e de la norme. Cette r egularis ee a un gradient lipschitzien, nous avons etudi e d'autres propri et es, d'int eir^ et en optimisation. Notre r esultat principal concerne les d eriv ees secondes. Sous des hypoth eses courantes en optimisation, la Moreau-Yosida est deux fois dii erentiable si et seulement si f l'est aussi. Au cours de notre etude, nous prouvons quelques r esultats g en eraux d'analyse convexe. Nous etablissons en particulier des relations primales-duales entre les d eveloppements au premier ordre d'une fonction convexe et de sa conjugu ee.
Fisheye image rectification for efficient large-scale stereo

Stereo vision using fisheye lenses has received greater attention in recent years due to its vast number of applications. As an essential prerequisite for stereo processing, this work proposes a fisheye image rectification method for efficient large-scale stereo. The scene distance was formulated within the spherical model. Reprojecting the original images using transverse Mercator projection enabled us to proof a theorem for which distance computing could be simplified to only a division operation of a constant and the disparity. Experimental results shows that stereo processing using this method could achieve much faster computational speed than existing approaches while maintaining satisfying matching quality.
Effects of Kinesthetic and Cutaneous Stimulation During the Learning of a Viscous Force Field

Haptic stimulation can help humans learn perceptual motor skills, but the precise way in which it influences the learning process has not yet been clarified. This study investigates the role of the kinesthetic and cutaneous components of haptic feedback during the learning of a viscous curl field, taking also into account the influence of visual feedback. We present the results of an experiment in which 17 subjects were asked to make reaching movements while grasping a joystick and wearing a pair of cutaneous devices. Each device was able to provide cutaneous contact forces through a moving platform. The subjects received visual feedback about joystick's position. During the experiment, the system delivered a perturbation through (1) full haptic stimulation, (2) kinesthetic stimulation alone, (3) cutaneous stimulation alone, (4) altered visual feedback, or (5) altered visual feedback plus cutaneous stimulation. Conditions 1, 2, and 3 were also tested with the cancellation of the visual feedback of position error. Results indicate that kinesthetic stimuli played a primary role during motor adaptation to the viscous field, which is a fundamental premise to motor learning and rehabilitation. On the other hand, cutaneous stimulation alone appeared not to bring significant direct or adaptation effects, although it helped in reducing direct effects when used in addition to kinesthetic stimulation. The experimental conditions with visual cancellation of position error showed slower adaptation rates, indicating that visual feedback actively contributes to the formation of internal models. However, modest learning effects were detected when the visual information was used to render the viscous field.
Evolution of cooperation through indirect reciprocity

How can cooperation through indirect reciprocity evolve and what would it be like? This problem has previously been studied by simulating evolution in a small group of interacting individuals, assuming no gene flow between groups. In these simulations, certain ‘image scoring’ strategies were found to be the most successful. However, analytical arguments show that it would not be in an individual's interest to use these strategies. Starting with this puzzle, we investigate indirect reciprocity in simulations based on an island model. This has an advantage in that the role of genetic drift can be examined. Our results show that the image scoring strategies depend on very strong drift or a very small cost of giving help. As soon as these factors are absent, selection eliminates image scoring. We also consider other possibilities for the evolution of indirect reciprocity. In particular, we find that the strategy of aiming for ‘good standing’ has superior properties. It can be an evolutionarily stable strategy and, even if not, it usually beats image scoring. Furthermore, by introducing quality variation among individuals into the model, we show that the standing strategy can be quality revealing, adding a new dimension to indirect reciprocity. Finally, we discuss general problems with currently popular modelling styles.
Loss of MARCH5 mitochondrial E3 ubiquitin ligase induces cellular senescence through dynamin-related protein 1 and mitofusin 1

Mitochondria constantly divide and combine through fission and fusion activities. MARCH5, a mitochondrial E3 ubiquitin ligase, has been identified as a molecule that binds mitochondrial fission 1 protein (hFis1), dynamin-related protein 1 (Drp1) and mitofusin 2 (Mfn2), key proteins in the control of mitochondrial fission and fusion. However, how these interactions control mitochondrial dynamics, and cellular function has remained obscure. Here, we show that shRNA-mediated MARCH5 knockdown promoted the accumulation of highly interconnected and elongated mitochondria. Cells transfected with MARCH5 shRNA or a MARCH5 RING domain mutant displayed cellular enlargement and flattening accompanied by increased senescence-associated β-galactosidase (SA-β-Gal) activity, indicating that these cells had undergone cellular senescence. Notably, a significant increase in Mfn1 level, but not Mfn2, Drp1 or hFis1 levels, was observed in MARCH5-depleted cells, indicating that Mfn1 is a major ubiquitylation substrate. Introduction of Mfn1T109A, a GTPase-deficient mutant form of Mfn1, into MARCH5-RNAi cells not only disrupted mitochondrial elongation, but also abolished the increase in SA-β-Gal activity. Moreover, the aberrant mitochondrial phenotypes in MARCH5-RNAi cells were reversed by ectopic expression of Drp1, but not by hFis1, and reversion of the mitochondria morphology in MARCH5-depleted cells was accompanied by a reduction in SA-β-Gal activity. Collectively, our data indicate that the lack of MARCH5 results in mitochondrial elongation, which promotes cellular senescence by blocking Drp1 activity and/or promoting accumulation of Mfn1 at the mitochondria.
Selection of Models of Lagged Identification Rates and Lagged Association Rates Using AIC and QAIC

The lagged identification rate is the probability of identifying an individual given its identification some time lag earlier. The lagged association rate is the probability that two individuals are associated given their association some time lag earlier. Models of lagged identification and association rates fit by maximizing the sums of non independent log-likelihoods have approximately unbiased parameter estimates. Simulations suggest that: Akaike-Information-Criterion often selects the true model of lagged identification rate data; quasi-Akaike-Information-Criterion performs better for lagged association rates; and confidence intervals for parameters are best obtained by bootstrap methods for lagged identification rates and quasi-likelihood or jackknife methods for lagged association rates.
The Effectiveness of Shared Reading Interventions with Families of Hispanic Prekindergarten Students

The Effectiveness of Shared Reading Interventions with Families of Hispanic Prekindergarten Students. (December 2011) Tracey Covington Hasbun, B.S.; M.I. S. , Stephen F. Austin University Chair of Advisory Committee: Dr. Hersh Waxman The purpose of this study was to examine the effects of parent or caregiver shared-reading interventions on Hispanic prekindergarten students’ language and literacy scores. In addition, this study investigated the effects of shared reading interventions on Spanish-speaking parents’ home literacy behaviors with their children. Teacher perceptions regarding the effectiveness of the intervention were also examined. The present mixed-methods study was similar to research conducted by Jiménez, Fillipini, & Gerber (2006) and Whitehurst, Falco, Lonigan, Fischel, DeBaryshe, ValdezManchaca, & Caulfield (1988) in that shared reading strategies were conducted with parents or caregivers and their children. Differing from previous research, the current study utilized an experimental pretest-posttest control group design, sessions were conducted over a 20-week period, students’ language and literacy scores were examined in both English and Spanish, and Hispanic preschool children and their parents or caregivers served as participants. Statistically significant results were found in students’ oral language scores in English and Spanish. The treatment group scored higher in both languages. Statistically significant results were also found in several aspects of parent or caregiver home literacy
Adaptive implementation of one-step-ahead optimal control via input matching

Directly adapting feedback control parameters to match an optimal input avoids the current limitations of indirect adaptive control and direct adaptive model matching. This original concept, termed input matching, allows combination of stable parameter adjustment algorithms and optimal performance considerations. Furthermore, the emphasis on input matching permits consistent control despite inconsistent parameter identification obviating efforts such as test or probing inputs required to insure consistent identification.
Aging results in copper accumulations in glial fibrillary acidic protein‐positive cells in the subventricular zone

Analysis of rodent brains with X‐ray fluorescence (XRF) microscopy combined with immunohistochemistry allowed us to demonstrate that local Cu concentrations are thousands of times higher in the glia of the subventricular zone (SVZ) than in other cells. Using XRF microscopy with subcellular resolution and intracellular X‐ray absorption spectroscopy we determined the copper (I) oxidation state and the sulfur ligand environment. Cu K‐edge X‐ray absorption near edge spectroscopy is consistent with Cu being bound as a multimetallic Cu‐S cluster similar to one present in Cu‐metallothionein. Analysis of age‐related changes show that Cu content in astrocytes of the SVZ increases fourfold from 3 weeks to 9 months, while Cu concentration in other brain areas remain essentially constant. This increase in Cu correlates with a decrease in adult neurogenesis assessed using the Ki67 marker (both, however, can be age‐related effects). We demonstrate that the Cu distribution and age‐related concentration changes in the brain are highly cell specific.
Proteolytic regulation of synaptic plasticity in the mouse primary visual cortex: analysis of matrix metalloproteinase 9 deficient mice

The extracellular matrix (ECM) is known to play important roles in regulating neuronal recovery from injury. The ECM can also impact physiological synaptic plasticity, although this process is less well understood. To understand the impact of the ECM on synaptic function and remodeling in vivo, we examined ECM composition and proteolysis in a well-established model of experience-dependent plasticity in the visual cortex. We describe a rapid change in ECM protein composition during Ocular Dominance Plasticity (ODP) in adolescent mice, and a loss of ECM remodeling in mice that lack the extracellular protease, matrix metalloproteinase-9 (MMP9). Loss of MMP9 also attenuated functional ODP following monocular deprivation (MD) and reduced excitatory synapse density and spine density in sensory cortex. While we observed no change in the morphology of existing dendritic spines, spine dynamics were altered, and MMP9 knock-out (KO) mice showed increased turnover of dendritic spines over a period of 2 days. We also analyzed the effects of MMP9 loss on microglia, as these cells are involved in extracellular remodeling and have been recently shown to be important for synaptic plasticity. MMP9 KO mice exhibited very limited changes in microglial morphology. Ultrastructural analysis, however, showed that the extracellular space surrounding microglia was increased, with concomitant increases in microglial inclusions, suggesting possible changes in microglial function in the absence of MMP9. Taken together, our results show that MMP9 contributes to ECM degradation, synaptic dynamics and sensory-evoked plasticity in the mouse visual cortex.
Substrate Type and Free Ammonia Determine Bacterial Community Structure in Full-Scale Mesophilic Anaerobic Digesters Treating Cattle or Swine Manure

The microbial-mediated anaerobic digestion (AD) process represents an efficient biological process for the treatment of organic waste along with biogas harvest. Currently, the key factors structuring bacterial communities and the potential core and unique bacterial populations in manure anaerobic digesters are not completely elucidated yet. In this study, we collected sludge samples from 20 full-scale anaerobic digesters treating cattle or swine manure, and investigated the variations of bacterial community compositions using high-throughput 16S rRNA amplicon sequencing. Clustering and correlation analysis suggested that substrate type and free ammonia (FA) play key roles in determining the bacterial community structure. The COD: NH4+-N (C:N) ratio of substrate and FA were the most important available operational parameters correlating to the bacterial communities in cattle and swine manure digesters, respectively. The bacterial populations in all of the digesters were dominated by phylum Firmicutes, followed by Bacteroidetes, Proteobacteria and Chloroflexi. Increased FA content selected Firmicutes, suggesting that they probably play more important roles under high FA content. Syntrophic metabolism by Proteobacteria, Chloroflexi, Synergistetes and Planctomycetes are likely inhibited when FA content is high. Despite the different manure substrates, operational conditions and geographical locations of digesters, core bacterial communities were identified. The core communities were best characterized by phylum Firmicutes, wherein Clostridium predominated overwhelmingly. Substrate-unique and abundant communities may reflect the properties of manure substrate and operational conditions. These findings extend our current understanding of the bacterial assembly in full-scale manure anaerobic digesters.