Miracle-dz/UniFAR-FTUs huggingface dataset:
Occupational therapy for rheumatoid arthritis: a systematic review.

Patients with rheumatoid arthritis (RA) show a reduction in physical capacities compared with healthy persons. Symptoms such as pain, fatique, stiffness, and decreased muscle strength cause difficulties with daily activities such as grooming and dressing, cooking a meal, cleaning, shopping, work, and leisure activities. The physical, personal, familial, social, and vocational consequences of RA are extensive. Occupational therapy (OT) is concerned with facililtating people in performing their activities of daily living overcoming barriers by maintaining or improving abilities, or compensating for decreased ability in the performance of occupation (1). The most important interventions in OT are training of skills, counseling, education about joint protection, prescription of assistive devices, and the provision of splints (2). Advice/ instruction in the use of assistive devices, training in self-care activities, and training in productivity activities are the 3 interventions for RA patients chosen most often by occuptional therapists (3). (aut. ref.)
An international study of the relation between somatic symptoms and depression.

BACKGROUND AND METHODS Patients with depression, particularly those seen by primary care physicians, may report somatic symptoms, such as headache, constipation, weakness, or back pain. Some previous studies have suggested that patients in non-Western countries are more likely to report somatic symptoms than are patients in Western countries. We used data from the World Health Organization's study of psychological problems in general health care to examine the relation between somatic symptoms and depression. The study, conducted in 1991 and 1992, screened 25,916 patients at 15 primary care centers in 14 countries on 5 continents. Of the patients in the original sample, 5447 underwent a structured assessment of depressive and somatoform disorders. RESULTS A total of 1146 patients (weighted prevalence, 10.1 percent) met the criteria for major depression. The range of patients with depression who reported only somatic symptoms was 45 to 95 percent (overall prevalence, 69 percent; P=0.002 for the comparison among centers). A somatic presentation was more common at centers where patients lacked an ongoing relationship with a primary care physician than at centers where most patients had a personal physician (odds ratio, 1.8; 95 percent confidence interval, 1.2 to 2.7). Half the depressed patients reported multiple unexplained somatic symptoms, and 11 percent denied psychological symptoms of depression on direct questioning. Neither of these proportions varied significantly among the centers. Although the overall prevalence of depressive symptoms varied markedly among the centers, the frequencies of psychological and physical symptoms were similar. CONCLUSIONS Somatic symptoms of depression are common in many countries, but their frequency varies depending on how somatization is defined. There is substantial variation in how frequently patients with depression present with strictly somatic symptoms. In part, this variation may reflect characteristics of physicians and health care systems, as well as cultural differences among patients.
Uniform Topology on Types and Strategic Convergence

We study the continuity of the correspondence of interim "-rationalizable actions in incomplete information games. We introduce a topology on types, called uniformweak topology, under which two types of a player are close if they have similar firstorder beliefs, attach similar probabilities to other players having similar first-order beliefs, and so on, where the degree of similarity is uniform over the levels of the belief hierarchy. This notion of proximity of types is an extension of the concept of common p-belief due to Monderer and Samet (1989). We show that, given any finite game, every action that is interim rationalizable for a finite type t remains interim "rationalizable for all types suciently close to t in the uniform-weak topology. Conversely, given any finite type t there exist " > 0 and a finite game such that some interim rationalizable action for t fails to be interim "-rationalizable for every type that is not close to t in the uniform-weak topology. Our results thus establish the equivalence between the uniform-weak topology and the strategic topology of Dekel, Fudenberg, and Morris (2006) around finite types.
Diminished plasma levels of common γ-chain cytokines in pulmonary tuberculosis and reversal following treatment

Background The immune response to tuberculosis (TB) is T cell dependent. T cells are the major facilitators of protection and effector functions with CD4+ T cells being the most important players, followed by CD8+ T cells. The common γ-chain cytokines IL-2, IL-7, IL-15, and IL-21 play a vital role in peripheral T cell growth and survival. However, the role of common γ-chain cytokines in pulmonary TB (PTB) is poorly understood. Aim and methods To examine the association of circulating common γ-chain cytokines with TB disease or infection, we examined the systemic levels of IL-2, IL-7, IL-15, and IL-21 in individuals with PTB, latent TB (LTB) or no TB infection (NTB). We also examined the levels of these cytokines in PTB individuals before and after anti-tuberculosis treatment. Results Circulating levels of IL-2, IL-7 and IL-21 were significantly diminished in PTB compared to LTB or NTB individuals. Moreover, TB antigen stimulated whole blood also exhibited diminished levels of common γ-chain cytokines in PTB compared to LTB or NTB individuals. The plasma levels of common γ-chain cytokines exhibited no significant association with the severity or extent of TB disease or with bacterial burdens. However, upon standard anti-TB treatment, both the systemic as well as the TB antigen stimulated levels of IL-2, IL-7 and IL-21 were significantly increased in PTB individuals. Conclusion Therefore our data demonstrate that diminished levels of common γ-chain cytokines are a common characteristic of PTB and potentially highlight the importance of boosting these responses to improve treatment outcomes.
Measuring Fragmentation of Two-Dimensional Resources Applied to Advance Reservation Grid Scheduling

Whenever a resource allocation fails although enough free capacity being available, fragmentation is easily spotted as cause. But how the fragmentation in a system requiring continuous allocations like time schedules or memory can be quantified is hardly analyzed. A Grid environment using advance reservation even combines two-dimensions: time and resource dimension. In this paper a new way to measure the fragmentation of a system in one dimension is proposed. This measure is then extended to incorporate also the second dimension. Extensive simulations showed that the proposed fragmentation measure is a good indicator of the state of the system.
Demographic differences in the prevalence, co-occurrence, and correlates of adolescent bullying at school.

BACKGROUND Despite a large literature on bullying, few studies simultaneously examine different dimensions of the phenomenon or consider how they vary by demographic characteristics. As a result, research findings in this area have been inconsistent. This article focuses on 2 dimensions of bullying behaviors--aggression and victimization--and examines demographic variation in their prevalence, co-occurrence, and association with other health outcomes. METHODS School-based surveys were administered to a census of 6th-12th graders in 16 school districts across a large metropolitan area in the United States (n = 79,492). A 2-factor scale assessed repeated experiences with bullying aggression and victimization. RESULTS Both dimensions of bullying tended to be more common among younger, male, African American and Native American students. There were, however, several exceptions as well as considerable variation in the magnitude of demographic differences. Most youth involved with bullying were either perpetrators or victims, but not both. For example, only 7.4% of all youths were classified as bully/victims. Substance use was more strongly associated with aggression, whereas depressive affect was more strongly associated with victimization. CONCLUSIONS Researchers should distinguish different dimensions of bullying and consider how they vary by demographic characteristics. In particular, repeated aggression and victimization largely involve different students and may require distinct approaches to prevention.
Familial risks in invasive and in situ cervical cancer by histological type

The Swedish Family‐Cancer Database was used to analyse familial relationships in mothers and daughters with invasive and in situ cervical cancers by histological type during the years 1958–1996, including a total of 21 727 and 191 081 cases, respectively. Familial standardized incidence ratios (SIRs) were calculated separately for mothers and daughters and for invasive and in situ squamous cell carcinoma (SCC) and adenocarcinoma. Familial risks were about 2.0 in invasive SCC and less in in situ SCC. Limited analyses could be carried out on adenocarcinoma because the number of cases was small. However, familial risks were not much smaller in families where only SCC was diagnosed compared with those where both SCC and adenocarcinoma were present. A comparison of cancers between mothers and daughters showed an association between cervical cancer and SCC of skin, and between cervical cancer and smoking‐related cancers. The familial risks were unaffected in Poisson regression analysis on many possible intervening variables. The data suggest that host factors modulate an individual's response to human papillomavirus infections.
Early Development of Olivocerebellar Projections in the Fetal Rat Using CGRP Immunocytochemistry

The expression of calcitonin gene‐related peptide (CGRP) immunoreactivity in certain inferior olivary neurons is transient and developmentally regulated. Labelled neurons begin to appear at embryonic day 16 (E16), and reach their maximal extent by postnatal day 2 (P2). The extinction of the labelling occurs between P13 and P16. Expression of CGRP immunoreactivity is also observed in a few cerebellar fibres from E17, when axons in the restiform bundle begin to enter medially the cerebellar parenchyma. Their maximal extent is reached by P6, and thereafter they slowly disappear following a precise pattern, although fibre extinction is not complete. The spatio‐temporal changes in the olivary distribution of the labelled neurons and the changes in the cerebellar labelled fibres follow the known pattern of topographic arrangement of the olivocerebellar system in adult rats. Moreover, the developmental phases of the CGRP‐labelled fibres in postnatal rats correspond to those known for climbing fibre phenotypic acquisition. Thus, CGRP immunocytochemistry identifies in the fetal rat a subset of inferior olivary neurons and their corresponding cerebellar climbing fibres. Using this approach, we have analysed some of the initial events leading to the formation of the olivocerebellar projection, and obtained the following information: (i) Olivocerebellar axons are not randomly distributed in the restiform bundle before they enter the cerebellum. (ii) In the presence of a large spectrum of choices at the surface of the rostral half of the cerebellar plate the labelled olivary axons begin to enter the cerebellum at a precise medial point to abut a region composed solely of migrating Purkinje cells, and establish contacts with their targets before these neurons reach their final cortical location. (iii) From E18 to E19, the bundle of labelled fibres loses its superficial location, being bypassed by migrating Purkinje cells, to occupy a region corresponding to the prospective white matter. This translocation is coincident with the occurrence of a second axonal entry point, somewhat more lateral than the previous one, and with the appearance of a new lateral stripe of labelled fibres. (iv) Both the early and the late appearing labelled stripes remain confined from the time of their formation in precise cerebellar territories, indicating that only some clusters of Purkinje cells are contacted by the CGRP fibres. The results obtained imply that there is neither a waiting period nor an initial phase of randomness in the formation of the olivocerebellar projection map. This absence of chaotic cerebellar invasion, and the high selectivity of the entry points, suggest that the orientation of CGRP‐positive olivocerebellar fibres towards their targets is regulated by positional information shared between subsets of olivary neurons and clusters of Purkinje cells. The result of this process would be the formation of a precocious coarse topography that would need further refinement.
Audio Chord Recognition with a Hybrid Recurrent Neural Network

In this paper, we present a novel architecture for audio chord estimation using a hybrid recurrent neural network. The architecture replaces hidden Markov models (HMMs) with recurrent neural network (RNN) based language models for modelling temporal dependencies between chords. We demonstrate the ability of feed forward deep neural networks (DNNs) to learn discriminative features directly from a time-frequency representation of the acoustic signal, eliminating the need for a complex feature extraction stage. For the hybrid RNN architecture, inference over the output variables of interest is performed using beam search. In addition to the hybrid model, we propose a modification to beam search using a hash table which yields improved results while reducing memory requirements by an order of magnitude, thus making the proposed model suitable for real-time applications. We evaluate our model's performance on a dataset with publicly available annotations and demonstrate that the performance is comparable to existing state of the art approaches for chord recognition.
Apparent digestibility of amino acids in raw and heated conventional and low-trypsin-inhibitor soybeans for pigs.

An experiment was conducted with ileally cannulated pigs to determine the apparent digestibility of amino acids and N in raw or heated conventional or low-trypsin-inhibitor soybeans. Six littermate barrows initially averaging 24 kg were fed cornstarch-based diets (10.5% CP, .68% lysine, 3,558 kcal of ME/kg) supplemented with raw (unheated), conventional soybeans; raw, low-trypsin-inhibitor soybeans; heated, conventional soybeans; heated, low-trypsin-inhibitor soybeans; or solvent-extracted soybean meal. Heating was achieved by autoclaving soybeans (after grinding) for 20 min at 110 degrees C. The urease activities of the two raw soybean sources were similar, but the trypsin inhibitor activity of the raw, low-trypsin-inhibitor soybeans was about one-half that of the raw, conventional soybeans. The lower trypsin inhibitor activity of the raw, low-trypsin-inhibitor soybeans was associated with an improvement in the apparent digestibility of amino acids and N compared with the raw, conventional soybeans (P less than .05). Heating reduced the urease and trypsin inhibitor activities and improved (P less than .05) the apparent digestibility of amino acids and N in both types of soybeans. However, the heated, conventional soybeans contained more trypsin inhibitor activity than the heated, low-trypsin-inhibitor soybeans and the digestibilities of the amino acids were lower (P less than .05). Although the urease and trypsin inhibitor activities of the two heated soybean sources were similar to or less than those of soybean meal, the digestibilities of amino acids were not as great (P less than .05) in the heated soybeans as in soybean meal. (ABSTRACT TRUNCATED AT 250 WORDS)
New insights in the recognition of the European ash species Fraxinus excelsior L. and Fraxinus angustifolia Vahl as useful tools for forest management

Common ash (Fraxinus excelsior L.) and narrow-leaved ash (F. angustifolia Vahl) are the most common ash species in Western Europe. The former is considered to be a highly valuable timber tree and contamination of its seed lots by the latter is strongly undesirable. We studied molecular, physiological and morphological characteristics that can help to detect the presence of F. angustifolia at the population level, either in seed and/or seedling samples, or in adult ash leave samples from natural or managed populations. First we developed two molecular markers, which correspond to a RAPD-SCAR marker and a nuclear microsatellite-derived marker. Results indicate that these markers are almost specific to one or the other species for a set of populations sampled across Europe. Second, first year dormancy was studied using germination tests without stratification. F. excelsior seeds did not germinate at all, while germinations were observed in samples of F. angustifolia and introgressed populations after 16 weeks. In addition, F. angustifolia embryo/seed length ratios at the dispersal stage were significantly higher than those from F. excelsior populations. This study provides straightforward and robust tools for avoiding commercial problems of impurity of seed lots and can help forest managers to certify common ash stands.
Evidence for orthologous seed weight genes in cowpea and mung bean based on RFLP mapping.

A well saturated genomic map is a necessity for a breeding program based on marker assisted selection. To this end, we are developing genomic maps for cowpea (Vigna unguiculata 2N = 22) and mung bean (Vigna radiata 2N = 22) based on restriction fragment length polymorphism (RFLP) markers. Using these maps, we have located major quantitative trait loci (QTLs) for seed weight in both species. Two unlinked genomic regions in cowpea contained QTLs accounting for 52.7% of the variation for seed weight. In mung bean there were four unlinked genomic regions accounting for 49.7% of the variation for seed weight. In both cowpea and mung bean the genomic region with the greatest effect on seed weight spanned the same RFLP markers in the same linkage order. This suggests that the QTLs in this genomic region have remained conserved through evolution. This inference is supported by the observation that a significant interaction (i.e., epistasis) was detected between the QTL(s) in the conserved region and an unlinked RFLP marker locus in both species.
The Past Twenty-five Years in Eye Banking

Purpose. This review of milestones and challenges in eye banking describes efforts made by dedicated eye bankers to ensure the quality and quantity of corneal tissue for corneal blind patients over the last 25 years. Methods. This account is the result of the recollection of the author, discussions with eye bankers, and a review of the literature, public documents, and Eye Bank Association of America (EBAA) records. Results. A measure of the success of eye banking is the fact that corneal transplant surgery is now scheduled as an elective procedure. Corneal tissue has also enjoyed a stellar safety record. This is due in part to the establishment of comprehensive medical standards by the EBAA, the accreditation of eye banks, and the training and certification of eye bank technicians. Conclusion. Advancements in eye banking over the last 25 years have improved the quality of life of several hundred thousand corneal blind persons in this country. More efforts must be made in the future to eliminate corneal blindness internationally.
Melioidosis in New Caledonia: a dominant strain in a transmission hotspot

SUMMARY Melioidosis is an infectious disease caused by Burkholderia pseudomallei, a bacterium endemic in Southeast Asia and northern Australia. In New Caledonia, sporadic cases were first described in 2005; since then, more cases have been identified. To improve our understanding of melioidosis epidemiology in New Caledonia, we compared the local cases and B. pseudomallei isolates with those from endemic areas. Nineteen melioidosis cases have been diagnosed in New Caledonia since 1999, mostly severe and with frequent bacteraemia, leading to three (16%) fatalities. All but one occurred in the North Province. Besides sporadic cases caused by non-clonal strains, we also identified a hotspot of transmission related to a clonal group of B. pseudomallei that is phylogenetically related to Australian strains.
Social challenges and supports from the perspective of individuals with Asperger syndrome and other autism spectrum disabilities

The study describes the perspectives of individuals with Asperger syndrome and other autism spectrum disabilities (ASDs) regarding social challenges and supports. Eighteen adults with ASDs were individually interviewed. They were asked to describe their experiences navigating their social worlds, and recommend effective social supports and strategies for improving social connectedness. Qualitative analyses of the interview transcripts revealed a number of common experiences including a profound sense of isolation, difficulty initiating social interactions, challenges relating to communication, longing for greater intimacy, desire to contribute to one's community, and effort to develop greater social/self-awareness. Commonly recommended social supports included external supports (e.g. activities based on shared interests, highly structured or scripted social activities, and small groups or dyads); communication supports (e.g. alternative modes of communication, explicit communication, and instruction in interpreting and using social cues); and self-initiated strategies for handling social anxiety (e.g. creative/improvisational outlets, physical activity, spiritual practice/organized religion, and time spent alone).
T-Cell Receptor Microclusters Critical for T-Cell Activation Are Formed Independently of Lipid Raft Clustering

ABSTRACT We studied the function of lipid rafts in generation and signaling of T-cell receptor microclusters (TCR-MCs) and central supramolecular activation clusters (cSMACs) at immunological synapse (IS). It has been suggested that lipid raft accumulation creates a platform for recruitment of signaling molecules upon T-cell activation. However, several lipid raft probes did not accumulate at TCR-MCs or cSMACs even with costimulation and the fluorescence resonance energy transfer (FRET) between TCR or LAT and lipid raft probes was not induced at TCR-MCs under the condition of positive induction of FRET between CD3ζ and ZAP-70. The analysis of LAT mutants revealed that raft association is essential for the membrane localization but dispensable for TCR-MC formation. Careful analysis of the accumulation of raft probes in the cell interface revealed that their accumulation occurred after cSMAC formation, probably due to membrane ruffling and/or endocytosis. These results suggest that lipid rafts control protein translocation to the membrane but are not involved in the clustering of raft-associated molecules and therefore that the lipid rafts do not serve as a platform for T-cell activation.