Miracle-dz/UniFAR-FTUs huggingface dataset:
A Theory of Engagement for Fostering Collective Action in Youth Leading Environmental Change

Abstract Youth and young adults play an important role in creating a much-needed major cultural shift toward sustainability and environmental justice. Such social change is significantly advanced when youth engage in collective environmental actions that go beyond greening their own personal practice. Although significant progress has been made in recent years in our understanding of how to engage youth in environmental action, what is currently lacking is a clear theory of engagement that unifies this knowledge in one comprehensive and easily accessible framework that is applicable in different cultural contexts. In this article, the authors describe a theory of engagement that was developed, applied, and tested in six countries in the context of the Youth Leading Environmental Change (YLEC) project. The authors describe the development process of the theory of engagement before discussing its core components, which include several facilitating factors of engagement and four active ingredients. A rationa.
Compact Orthomode Transducer Polarizer Based on a Tilted-Waveguide T-Junction

An alternative device to the well-known septum polarizer is proposed, which also provides the double function of an orthomode and a polarizer. It is based on a waveguide T-junction between a common dual-polarization waveguide and a tilted rectangular single-mode waveguide, and offers an intrinsically shorter geometry in the axial dimension, an advisable property when searching for compact antenna assemblies. The analysis of this new device is presented, along with the derivation and introduction of the S-parameters referred to the circularly polarized modes in the common waveguide. The working principle of the proposed T-junction is also explained in detail. A breadboard is designed, and its simulation and measurement results are presented. As a conclusion, the proposed device seems worthy of comparison in its electrical performances to the septum polarizer, showing some advantages in terms of geometrical dimensions and manufacturability.
A tablet-based intervention to manipulate social cognitive bias in schizophrenia

ABSTRACT Interventions to decrease cognitive bias in schizophrenia have yielded limited benefit. One reason may be that people receive insufficient rehearsal applying debiasing skills while biases are actively affecting their thinking. The authors designed Mary/Eddie/Bill-internet (MEBi) to (1) teach debiasing skills to people with schizophrenia, (2) activate biases during training sessions, and (3) provide daily in-home rehearsal of debiasing skills using tablet computer interface. In this proof-of-concept trial, 28 adults with schizophrenia used the MEBi tablet “app” for one month. Fourteen completed a version of MEBi including only the debiasing skills, and 10 completed a version including a bias activation component. Participants completed pretest and posttest measures of social cognition and social functioning. Results showed that participants in both groups adhered to the intervention and learned the debiasing skills. Participants who were only taught the debiasing skills showed significant improvements in social cognitive bias, accuracy, and self-reported social functioning relative to participants who also received the bias-activation manipulation—who showed worsening social cognitive bias. Results suggest that it is feasible to affect social cognition in schizophrenia through in-home tablet-based training. However, more metacognitive training is needed to help people apply debiasing techniques when bias is activated.
Presidential coattails in coalitional presidentialism

Research on presidential coattails in elections has focused nearly exclusively on two-party systems like the United States. Much less is known, however, about presidential coattails in multiparty systems where electoral and governing coalitions are common currency. Under coalitional presidentialism, we argue that presidential coattails are diffused, benefiting the president’s party but also her coalition party members, especially those most strongly associated with the coalition itself. Using electoral data from Chile and Brazil, two widely studied but distinct cases of coalitional presidentialism, we find strong evidence supporting this claim. The results carry important implications for students of coalitional presidentialism, presidential coattails, and party systems, more generally.
Negative feedback effects on star formation history and cosmic reionization

Context. The mechanical and radiative feedback that exists in the star formation history affects the subsequent star formation rate. Aims. After considering the effects of negative feedback on the process of star formation, we explore the relationship between star formation process and the associated feedback, by investigating how the mechanical feedback from supernovae(SNe) and radiative feedback from luminous objects regulate the star formation rate and therefore affect the cosmic reionization. Methods. Based on our present knowledge of the negative feedback theory and some numerical simulations, we construct an analytic model in the framework of the Lambda cold dark matter model. In certain parameter regions, our model can explain some observational results properly. Results. In large halos (T(vir) > 10(4) K), both mechanical and radiative feedback have a similar behavior: the relative strength of negative feedback reduces as the redshift decreases. In contrast, in small halos (T(vir) < 10(4) K) that are thought to breed the first stars at early time, the radiative feedback gets stronger when the redshift decreases. And the star formation rate in these small halos depends very weakly on the star-formation efficiency. Conclusions. Our results show that the radiative feedback is important for the early generation stars. It can suppress the star formation rate considerably. But the mechanical feedback from the SNe explosions is not able to affect the early star formation significantly. The early star formation in small-halo objects is likely to be self-regulated. The radiative and mechanical feedback dominates the star formation rate of the PopII/I stars all along. The feedback from first generation stars is very strong and should not be neglected. However, their effects on the cosmic reionization are not significant, which results in a small contribution to the optical depth of Thomson scattering.
Head-to-toe whole-body MRI in psoriatic arthritis, axial spondyloarthritis and healthy subjects: first steps towards global inflammation and damage scores of peripheral and axial joints.

OBJECTIVES By whole-body MRI (WBMRI), we aimed to examine the frequency and distribution of inflammatory and structural lesions in PsA patients, SpA patients and healthy subjects (HSs), to introduce global WBMRI inflammation/damage scores, and to assess WBMRI's reproducibility and correlation with conventional MRI (convMRI). METHODS WBMRI (3.0-T) of patients with peripheral PsA (n = 18) or axial SpA (n = 18) and of HS (n = 12) was examined for proportion of evaluable features (readability) and the presence and pattern of lesions in axial and peripheral joints. Furthermore, global WBMRI scores of inflammation and structural damage were constructed, and WBMRI findings were compared with clinical measures and convMRI (SpA/HS: spine and SI joints; PsA/HS: hand). RESULTS The readability (92-100%) and reproducibility (intrareader intraclass correlation coefficient: 0.62-1.0) were high in spine/SI joint, but lower in the distal peripheral joints. Wrists, shoulders, knees, ankles and MTP joints were most commonly involved, with frequency of synovitis > bone marrow oedema (BMO) > erosion. WBMRI global BMO scores of peripheral and axial joints were higher in PsA {median 7 [interquartile range (IQR) 3-15]} and SpA [8 (IQR 2-14)] than in HSs [2.5 (IQR 1-4.5)], both P < 0.05. WBMRI global structural damage scores (erosion, fat infiltration and ankylosis) were higher in SpA [7 (IQR 3-12)] than HSs [1.5 (IQR 0-4.5)], P = 0.012. Correlations between WBMRI and convMRI spine and SI joint scores were ρ = 0.20-0.78. CONCLUSION WBMRI allows simultaneous assessment of peripheral and axial joints in PsA and SpA, and the distribution of inflammatory and structural lesions and global scores can be determined. The study strongly encourages further development and longitudinal testing of WBMRI techniques and assessment methods in PsA and SpA.
History as a double-edged sword

Recent evidence suggests that historical boundary precedents play a central role in the outbreak, character, and long-term consequences of territorial disputes. The institutional theory of borders holds promise in explaining why leaders find old borders to be attractive as new borders. However, the mechanisms that link historical precedents to territorial claims and their consequences are not fully specified in the extant literature. I argue that there are three key arguments that can explain why boundary precedents are associated with subsequent disputes: ease of justification, perpetual conflict over territories of particular value, and persistent coordination around old borders. I argue that the coordination mechanism is essential to understanding the connections between historical boundary precedents and territorial disputes.
ACCRETION DISK MODEL OF SHORT-TIMESCALE INTERMITTENT ACTIVITY IN YOUNG RADIO SOURCES

We associate the existence of short-lived compact radio sources with the intermittent activity of the central engine caused by a radiation pressure instability within an accretion disk. Such objects may constitute a numerous subclass of gigahertz-peaked spectrum sources, in accordance with the population studies of radio-loud active galaxies, as well as detailed investigations of their radio morphologies. We perform the model computations assuming the viscosity parameterization as proportional to a geometrical mean of the total and gas pressure. The implied timescales are consistent with the observed ages of the sources. The duration of an active phase for a moderate accretion rate is short enough (less than 103–104 yr) that the ejecta are confined within the host galaxy and thus these sources cannot evolve into large size radio galaxies unless they are close to the Eddington limit.
Income Distribution, Debt Accumulation, and Financial Fragility in a Kaleckian Model with Labor Supply Constraints

This paper investigates the effect of changes in the retention ratio, profit share, interest rate, and natural rate of growth on the rate of capital accumulation and the financial structure of firms by using a Kaleckian growth model with labor supply constraints. We show that if the economy exhibits a debt-burdened regime, depending on certain conditions, there could be cyclical fluctuations such that the financial structure of firms changes periodically from speculative finance to Ponzi finance.
Treatment outcomes of surgery, antifungal therapy and immunotherapy in ocular and vascular human pythiosis: a retrospective study of 18 patients.

OBJECTIVES Human pythiosis is a life-threatening disease for which no standard treatment protocols with proven efficacy exist. We present the results of our institutional pythiosis treatment protocol, composed of surgery, antifungal agents, iron chelator (only vascular cases) and immunotherapy. METHODS We retrospectively analysed patients with proven vascular and ocular pythiosis in King Chulalongkorn Memorial Hospital from April 2003 to May 2013. Fisher's exact test and Wilcoxon's rank-sum test were used. The MICs of seven antifungal agents and combination drugs were investigated in eight clinical Pythium insidiosum strains. RESULTS Eighteen patients were evaluated. Disease-free surgical margins were obtained in all surviving patients with vascular pythiosis (P = 0.08). Patients who underwent eye enucleation were significantly older than those who did not (P < 0.05). Patients with vascular or ocular pythiosis did not differ significantly in the median time from disease onset to first surgery or in the relationship between the type of P. insidiosum antigen and treatment outcomes. In vitro susceptibility profiles of all isolates demonstrated that no single agent or combination treatment was substantially more effective than the others. The highest MIC was detected for amphotericin B, followed in order by voriconazole, fluconazole, anidulafungin, caspofungin, itraconazole and terbinafine. No synergistic effects of the combination drug treatments were found. CONCLUSIONS Surgery with adequate surgical margins is a crucial determinant of survival in patients with vascular pythiosis. Itraconazole and terbinafine do not have synergistic effects on Thai P. insidiosum strains. The role of immunotherapy remains inconclusive for both vascular and ocular pythiosis.
Defying Food – How Distance Determines Monkeys’ Ability to Inhibit Reaching for Food

Objects, such as food, in the environment automatically activate and facilitate affordances, the possibilities for motoric movements in interaction with the objects. Previous research has shown that affordance activation is contingent upon the distance of the object with only proximal objects activating potential movements. However, the effect of affordance-activating proximal objects on the ability to inhibit movements has been unaddressed. The current study addressed this question with two experiments on long-tailed macaques. In both experiments monkeys were situated behind a Plexiglass screen that prevented direct access to food placed right behind the screen. The food could only be reached via a detour through one of two holes on the sides of the screen. It was assessed whether monkeys’ ability to inhibit the unsuccessful immediate reaching movement forward toward the food depended on the distance at which the food was presented. Results of both Experiments revealed that monkeys reached for the proximally positioned food significantly more than for the distally positioned food, despite this Plexiglass screen preventing successful obtainment of the food. The findings reveal the effect of proximal, affordance-activating objects on the ability to resist movements involved in interacting with the objects. Implications for humans, living in environments in which proximal, or accessible food is constantly available are discussed. The findings can contribute to an understanding of why resisting accessible food in the environment is often unsuccessful.
Circadian modulation of calcium levels in cells in the suprachiasmatic nucleus

There is reason to believe that resting free calcium concentration [Ca2+]i in neurons in the suprachiasmatic nucleus (SCN) may vary with the circadian cycle. In order to start to examine this hypothesis, optical techniques were utilized to estimate resting Ca2+ levels in SCN cells in a rat brain slice preparation. [Ca2+]i measured from the soma was significantly higher in the day than in the night. Animals from a reversed light–dark cycle were used to confirm that the phase of the rhythm was determined by the prior light–dark cycle. The rhythm in Ca2+ levels continued to be expressed in tissue collected from animals maintained in constant darkness, thus confirming the endogenous nature of this variation. Interestingly, the rhythm in Ca2+ levels was not observed when animals were housed in constant light. Finally, the rhythm in Ca2+ levels was prevented when slices were exposed to tetrodotoxin (TTX), a blocker of voltage‐sensitive sodium channels. Similar results were obtained with the voltage‐sensitive Ca2+ channel blocker methoxyverapamil. These observations suggest a critical role for membrane events in driving the observed rhythm in Ca2+. Conceptually, this rhythm can be thought of as an output of the circadian oscillator. Because [Ca2+]i is known to play a critical role in many cellular processes, the presence of this rhythm is likely to have many implications for the cell biology of SCN neurons.
Lack of cross‐resistance to FF‐10501, an inhibitor of inosine‐5′‐monophosphate dehydrogenase, in azacitidine‐resistant cell lines selected from SKM‐1 and MOLM‐13 leukemia cell lines

Resistance to azacitidine is a major issue in the treatments of myelodysplastic syndrome and acute myeloid leukemia, and previous studies suggest that changes in drug metabolism are involved in the resistance. Therefore, drugs with mechanisms resistant or alternative to such metabolic changes have been desired for the treatment of resistant disease. We generated azacitidine‐resistant cells derived from SKM‐1 and MOLM‐13 leukemia cell lines in vitro, analyzed the mechanisms, and examined the impact on the efficacy of other antimetabolic drugs. It appeared that the cell growth‐inhibitory effect of azacitidine, expression levels of uridine–cytidine kinase 2, and the concentrations of azacitidine triphosphate were remarkably decreased in the resistant cells compared with those in parent cells. These results were consistent with previous observations that azacitidine resistance is derived from metabolic changes. Cross‐resistance of greater than 10‐fold (shift in IC50 value) was observed in azacitidine‐resistant cells for decitabine and for cytarabine, but not for gemcitabine or the inosine‐5′‐monophosphate dehydrogenase (IMPDH) inhibitors FF‐10501 and mycophenolate mofetil (cross‐resistance to 5‐fluorouracil was cell line dependent). The IMPDH inhibitors maintained their cell growth‐inhibitory activities in the azacitidine‐resistant cell lines, in which the levels of adenine phosphoribosyltransferase (which converts FF‐10501 to its active form, FF‐10501 ribosylmonophosphate [FF‐10501RMP]), FF‐10501RMP, and the target enzyme, IMPDH, were equivalent to those in the parent cell lines. These results suggest that an IMPDH inhibitor such as FF‐10501 could be an alternative therapeutic treatment for leukemia patients with acquired resistance to azacitidine.
Stereociliary Myosin-1c Receptors Are Sensitive to Calcium Chelation and Absent from Cadherin 23 Mutant Mice

The identities of some of the constituents of the hair-cell transduction apparatus have been elucidated only recently. The molecular motor myosin-1c (Myo1c) functions in adaptation of the hair-cell response to sustained mechanical stimuli and is therefore an integral part of the transduction complex. Recent data indicate that Myo1c interacts in vitro with two other molecules proposed to be important for transduction: cadherin 23 (Cdh23), a candidate for the stereociliary tip link, and phosphatidylinositol 4,5-bisphosphate (PIP2), which is abundant in the membranes of hair-cell stereocilia. It is not known, however, whether these interactions occur in hair cells. Using an in situ binding assay on saccular hair cells, we demonstrated previously that Myo1c interacts with molecules at stereociliary tips, the site of transduction, through sequences contained within its calmodulin (CaM)-binding neck domain, which can bind up to four CaM molecules. In the current study, we identify the second CaM-binding IQ domain as a region of Myo1c that mediates CaM-sensitive binding to stereociliary tips and to PIP2 immobilized on a solid support. Binding of Myo1c to stereociliary tips of cochlear and vestibular hair cells is disrupted by treatments that break tip links. In addition, Myo1c does not bind to stereocilia from mice whose hair cells lack Cdh23 protein despite the presence of PIP2 in the stereociliary membranes. Collectively, our data suggest that Myo1c and Cdh23 interact at the tips of hair-cell stereocilia and that this interaction is modulated by CaM.
Racial-Ethnic Socialization and Achievement: The Mediating Role of Academic Engagement

This brief report examined how racial socialization is directly and indirectly related to academic achievement for African Americans attending a predominantly White institution. We expected that students who received more racial socialization would exhibit better academic engagement and this, in turn, would help explain their academic achievement. The sample included 226 African American college students (76% female) between the ages of 18 and 22 years (Mage = 20.05) who were recruited from the subject pool of the university’s psychology department and through general advertising across the university’s campus. Students participated by completing an online survey. Path analyses indicate that racial socialization messages about cultural pride (i.e., cultural socialization) were associated with academic achievement directly and indirectly through students’ engagement with school. However, racial socialization messages about future barriers were directly associated with academic achievement but not mediated by school engagement. Implications for studying academic engagement and racial socialization in African American college students’ academic achievement are discussed.
Functional and Transcriptional Induction of Aquaporin-1 Gene by Hypoxia; Analysis of Promoter and Role of Hif-1α

Aquaporin-1 (AQP1) is a water channel that is highly expressed in tissues with rapid O2 transport. It has been reported that this protein contributes to gas permeation (CO2, NO and O2) through the plasma membrane. We show that hypoxia increases Aqp1 mRNA and protein levels in tissues, namely mouse brain and lung, and in cultured cells, the 9L glioma cell line. Stopped-flow light-scattering experiments confirmed an increase in the water permeability of 9L cells exposed to hypoxia, supporting the view that hypoxic Aqp1 up-regulation has a functional role. To investigate the molecular mechanisms underlying this regulatory process, transcriptional regulation was studied by transient transfections of mouse endothelial cells with a 1297 bp 5′ proximal Aqp1 promoter-luciferase construct. Incubation in hypoxia produced a dose- and time-dependent induction of luciferase activity that was also obtained after treatments with hypoxia mimetics (DMOG and CoCl2) and by overexpressing stabilized mutated forms of HIF-1α. Single mutations or full deletions of the three putative HIF binding domains present in the Aqp1 promoter partially reduced its responsiveness to hypoxia, and transfection with Hif-1α siRNA decreased the in vitro hypoxia induction of Aqp1 mRNA and protein levels. Our results indicate that HIF-1α participates in the hypoxic induction of AQP1. However, we also demonstrate that the activation of Aqp1 promoter by hypoxia is complex and multifactorial and suggest that besides HIF-1α other transcription factors might contribute to this regulatory process. These data provide a conceptual framework to support future research on the involvement of AQP1 in a range of pathophysiological conditions, including edema, tumor growth, and respiratory diseases.