Miracle-dz/UniFAR-FTUs huggingface dataset:
Interaction of Bnr1p with a Novel Src Homology 3 Domain-containing Hof1p

Proteins containing the formin homology (FH) domains FH1 and FH2 are involved in cytokinesis or establishment of cell polarity in a variety of organisms. We have shown that the FH proteins Bni1p and Bnr1p are potential targets of the Rho family small GTP-binding proteins and bind to an actin-binding protein, profilin, at their proline-rich FH1 domains to regulate reorganization of the actin cytoskeleton in the yeast Saccharomyces cerevisiae. We found here that a novel Src homology 3 (SH3) domain-containing protein, encoded by YMR032w, interacted with Bnr1p in a GTP-Rho4p-dependent manner through the FH1 domain of Bnr1p and the SH3 domain of Ymr032wp. Ymr032wp weakly bound to Bni1p. Ymr032wp was homologous to cdc15p, which is involved in cytokinesis inSchizosaccharomyces pombe, and we named this geneHOF1 (homolog of cdc 15). Both Bnr1p and Hof1p were localized at the bud neck, and both the bnr1 andhof1 mutations showed synthetic lethal interactions with the bni1 mutation. The hof1 mutant cells showed phenotypes similar to those of the septin mutants, indicating thatHOF1 is involved in cytokinesis. These results indicate that Bnr1p directly interacts with Hof1p as well as with profilin to regulate cytoskeletal functions in S. cerevisiae.
Clinical Interventions in Aging Dovepress Correlation between Thoracolumbar Curvatures and Respiratory Function in Older Adults

hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms Abstract: Aging is associated with alterations in thoracolumbar curvatures and respiratory function. Research information regarding the correlation between thoracolumbar curvatures and a comprehensive examination of respiratory function parameters in older adults is limited. The aim of the present study was to examine the correlation between thoracolumbar curvatures and respiratory function in community-dwelling older adults. Thoracolumbar curvatures (thoracic and lumbar) were measured using a motion tracker. Respiratory function parameters such as lung function, respiratory rate, respiratory muscle strength and respiratory muscle thickness (diaphragm and intercostal) were measured using a spirometer, triaxial accelerometer, respiratory pressure meter and ultrasound imaging, respectively. Sixty-eight community-dwelling older males and females from Kuala Lumpur, Malaysia, with mean (standard deviation) age of 66.63 (5.16) years participated in this cross-sectional study. The results showed that mean (standard deviation) thoracic curvature angle and lumbar curvature angles were −46.30° (14.66°) and 14.10° (10.58°), respectively. There was a significant negative correlation between thoracic curvature angle and lung function (forced expiratory volume in 1 second: r=−0.23, P,0.05; forced vital capacity: r=−0.32, P,0.05), quiet expiration intercostal thickness (r=−0.22, P,0.05) and deep expiration diaphragm muscle thickness (r=−0.21, P,0.05). The lumbar curvature angle had a significant negative correlation with respiratory muscle strength (r=−0.29, P,0.05) and diaphragm muscle thickness at deep inspiration (r=−0.22, P,0.05). However, respiratory rate was correlated neither with thoracic nor with lumbar curvatures. The findings of this study suggest that increase in both thoracic and lumbar curvatures is correlated with decrease in respiratory muscle strength, respiratory muscle thickness and some parameters of lung function. Clinically, both thoracic and lumbar curvatures, respiratory muscles and lung function should be taken into consideration in the holistic management of respiratory function among older adults.
A Multi-Center, Randomized, Controlled, Pivotal Study to Assess the Safety and Efficacy of a Selective Cytopheretic Device in Patients with Acute Kidney Injury

Objective Acute kidney injury (AKI) is a highly morbid condition in critically ill patients that is associated with high mortality. Previous clinical studies have demonstrated the safety and efficacy of the Selective Cytopheretic Device (SCD) in the treatment of AKI requiring continuous renal replacement therapy in the intensive care unit (ICU). Design, Setting, Patients A randomized, controlled trial of 134 ICU patients with AKI, 69 received continuous renal replacement therapy (CRRT) alone and 65 received SCD therapy. Results No significant difference in 60-day mortality was observed between the treated (27/69; 39%) and control patients (21/59; 36%, with six patients lost to follow up) in the intention to treat (ITT) analysis. Of the 19 SCD subjects (CRRT+SCD) and 31 control subjects (CRRT alone) who maintained a post-filter ionized calcium (iCa) level in the protocol’s recommended range (≤ 0.4mmol/L) for greater or equal to 90% of the therapy time, 60-day mortality was 16% (3/19) in the SCD group compared to 41% (11/27) in the CRRT alone group (p = 0.11). Dialysis dependency showed a borderline statistically significant difference between the SCD treated versus control CRRT alone patients maintained for ≥ 90% of the treatment in the protocol’s recommended (r) iCa target range of ≤ 0.4 mmol/L with values of, 0% (0/16) and 25% (4/16), respectively (P = 0.10). When the riCa treated and control subgroups were compared for a composite index of 60 day mortality and dialysis dependency, the percentage of SCD treated subjects was 16% versus 58% in the control subjects (p<0.01). The incidence of serious adverse events did not differ between the treated (45/69; 65%) and control groups (40/65; 63%; p = 0·86). Conclusion SCD therapy may improve mortality and reduce dialysis dependency in a tightly controlled regional hypocalcaemic environment in the perfusion circuit. Trial Registration ClinicalTrials.gov NCT01400893 http://clinicaltrials.gov/ct2/show/NCT01400893
The Influence of Crack Length and Delamination Width on the Mode-III Energy Release Rate of Laminated Composites

In this article, the modified split-cantilever beam (MSCB) is applied to investigate the dependence of the mode-III energy release rate (at crack initiation) on the crack length and the specimen width. The main goal of this study is to apply the same specimen geometry to both double-cantilever beam and end-notched flexure systems. The energy release rate of the specimen was calculated by an improved beam theory scheme, which was used to reduce the experimental data. The obtained results are comparable to those obtained by mode-I and mode-II tests, and they indicate the important role of the MSCB specimen. The results show that the energy release rate decreases significantly with the initial crack length and there is no crack length where the energy release rate becomes independent of it.
Glial process elongation and branching in the developing murine neocortex: A qualitative and quantitative immunohistochemical analysis

Cells of astroglial lineage in the murine cerebrum undergo a succession of transformations during prenatal and early postnatal development. The bipolar radial cell, the earliest astroglial form to appear, provides a radially aligned, parallel array of fibers that serves as a guide to neuronal migration. The multipolar astrocyte is the representative of this lineage that persists in the adult cerebrum. The processes of the multipolar astrocytes form a complex reticulum, which is considered critical to the development, function, and maintenance of neural circuits. A monopolar radial cell appears to be transitional between the two. The shift from the radial glial fiber system to a diffuse glial network is achieved largely in the E17‐P2 interval in the mouse. This phenomenon has been studied qualitatively and quantitatively by staining cerebral tissue with monoclonal antibody RC2, a specific and sensitive ligand for cells of astroglial lineage in the mouse.
Adaptive CFAR Radar Detection With Conic Rejection

In this paper, we deal with the problem of adaptive signal detection in colored Gaussian disturbance. Since the classical receivers may exhibit severe performance degradations in the presence of steering vector mismatches and sidelobe interfering signals, we try to account for the quoted drawbacks, very usual in realistic radar scenarios, at the design stage. To this end, we first characterize the set where the useful received signal may lie and its complement, i.e., the set which may contain the signals to be rejected. Then we resort to the generalized likelihood ratio (GLR) principle and devise detectors capable of operating in the presence of array response mismatches and sidelobe interfering signals. At the analysis stage, we assess the performance of the newly introduced receivers also in comparison with previously proposed detectors. The results show that the new processors are characterized by a wide range of performance compromises, selectable at the design stage through the regulation of a design parameter, between the detection of useful signals and the rejection of sidelobe interference
A Mathematical Model of Alzheimer's Disease and the Apoe Gene

Abstract Alzheimer's disease (AD) accounts for a significant proportion of long-term care costs. The recent discovery that the ε4 allele of the ApoE gene indicates a predisposition to earlier onset of AD raises questions about the potential for adverse selection in long-term care insurance, about long-term care costs in general, and about the potential effects on costs of gene therapy, or better targetted treatments for AD. This paper describes a simple Markov model for AD, and the estimation of the transition intensities from the medical and epidemiological literature.
Heat kernel estimates for the Dirichlet fractional Laplacian

In this paper, we consider the fractional Laplacian -(-? )a/2 on an open subset in Rd with zero exterior condition. We establish sharp two-sided estimates for the heat kernel of such Dirichlet fractional Laplacian in C1.1 open sets. This heat kernel is also the transition density of a rotationally symmetric a-stable process killed upon leaving a C1.1 open set. Our results are the first sharp two-sided estimates for the Dirichlet heat kernel of a non-local operator on open sets.
A semantics-based measure of emoji similarity

Emoji have grown to become one of the most important forms of communication on the web. With its widespread use, measuring the similarity of emoji has become an important problem for contemporary text processing since it lies at the heart of sentiment analysis, search, and interface design tasks. This paper presents a comprehensive analysis of the semantic similarity of emoji through embedding models that are learned over machine-readable emoji meanings in the EmojiNet knowledge base. Using emoji descriptions, emoji sense labels and emoji sense definitions, and with different training corpora obtained from Twitter and Google News, we develop and test multiple embedding models to measure emoji similarity. To evaluate our work, we create a new dataset called EmoSim508, which assigns human-annotated semantic similarity scores to a set of 508 carefully selected emoji pairs. After validation with EmoSim508, we present a real-world use-case of our emoji embedding models using a sentiment analysis task and show that our models outperform the previous best-performing emoji embedding model on this task. The EmoSim508 dataset and our emoji embedding models are publicly released with this paper and can be downloaded from http://emojinet.knoesis. org/.
Comparison between effects of 3‐isobutyl‐1‐methylxanthine and FSH on gap junctional communication, LH‐receptor expression, and meiotic maturation of cumulus–oocyte complexes in pigs

We investigated cAMP content, gap junctional communications (GJCs) status, and LH‐receptor (LH‐R) expression in porcine cumulus–oocyte complexes (COCs) during in vitro maturation treated with the phosphodiesterase (PDE) inhibitor 3‐isobutyl‐1‐methylxanthine (IBMX) or with FSH. COCs were cultured for 20 hr (1st culture) in M199 containing 10% FBS (basic medium, BM group) or BM supplemented with FSH (FSH group) or IBMX (IBMX group). Each COC was then transferred into BM containing both FSH and LH and cultured for an additional 24 hr (2nd culture). The proportions of metaphase‐II (M‐II) oocytes at the end of the 2nd culture did not differ between the FSH (75.7%) and IBMX (68.2%) groups, whereas only 10.1% of oocytes in the BM group reached the M‐II stage. During the 1st culture, the cAMP content of COCs and oocytes became significantly higher in the FSH and IBMX groups than in the BM group; the FSH group had a far greater increment than did the IBMX group. GJCs in the FSH and BM groups gradually closed with increasing duration of the 1st culture, whereas a significantly higher proportion of COCs in the IBMX group still had open GJCs than in the other two groups. Furthermore, LH‐R mRNA expression significantly increased in both the FSH and IBMX groups compared with the BM group. These results suggest that inhibition of PDEs in porcine COCs make the oocyte ready for release from meiotic arrest, and that maintenance of a moderate cAMP content may prolong GJCs and stimulate LH‐R expression. Mol. Reprod. Dev. 75: 857–866, 2008. © 2007 Wiley‐Liss, Inc.
Arthrodesis of the First Metatarsophalangeal Joint with Vitallium Plate Fixation

Forty-seven patients (58 feet) underwent first metatarsophalangeal joint fusion with a small Vitallium plate (Howmedica, Inc., Rutherford, NJ). Congruous joint surfaces were prepared with either cone-shaped or cup-shaped reamers. At an average follow-up of 19.2 months, 98% (57 feet) were successfully fused. Ninety-three percent (54 feet) noted good or excellent results. Plate removal was necessary in only 7% (4 feet) of cases. Complications included nonunion with plate breakage in 2% (1 foot) and delayed union in 2% (1 foot) of cases. This technique was useful and predictable in achieving successful fusion of the first metatarsophalangeal joint.
Effect of Itraconazole on Pharmacokinetics of Paroxetine: The Role of Gut Transporters

A recent in vitro study has shown that paroxetine is a substrate of P-glycoprotein. However, there was no in vivo information indicating the involvement of P-glycoprotein on the pharmacokinetics of paroxetine. The aim of this study was to examine the effects of itraconazole, a P-glycoprotein inhibitor, on the pharmacokinetics of paroxetine. Two 6 day courses of either 200 mg itraconazole daily or placebo with at least a 4 week washout period were conducted. Thirteen volunteers took a single oral 20 mg dose of paroxetine on day 6 of both courses. Plasma concentrations of paroxetine were monitored up to 48 hours after the dosing. Compared with placebo, itraconazole treatment significantly increased the peak plasma concentration (Cmax) of paroxetine by 1.3 fold (6.7 ± 2.5 versus 9.0 ± 3.3 ng/mL, P < 0.05) and the area under the plasma concentration-time curve from zero to 48 hours [AUC (0-48)] of paroxetine by 1.5 fold (137 ± 73 versus 199 ± 91 ng*h/mL, P < 0.01). Although elimination half-life differed significantly (16.1 ± 3.4 versus 18.8 ± 5.9 hours, P < 0.05), the alteration was small (1.1 fold). The present study demonstrated that the bioavailability of paroxetine was increased by itraconazole, suggesting a possible involvement of P-glycoprotein in the pharmacokinetics of paroxetine.
The use of halloysite clay and carboxyl-functionalised multi-walled carbon nanotubes for recombinant LipL32 antigen delivery enhanced the IgG response

We studied the feasibility of using halloysite clay nanotubes (HNTs) and carboxyl-functionalised multi-walled carbon nanotubes (COOH-MWCNTs) as antigen carriers to improve immune responses against a recombinant LipL32 protein (rLipL32). Immunisation using the HNTs or COOH-MWCNTs significantly increased the rLipL32-specific IgG antibody titres (p < 0.05) of Golden Syrian hamsters. None of the vaccines tested conferred protection against a challenge using a virulent Leptospira interrogans strain. These results demonstrated that nanotubes can be used as antigen carriers for delivery in hosts and the induction of a humoral immune response against purified leptospiral antigens used in subunit vaccine preparations.
Lexical translation with application to image searching on the web

We introduce a novel approach to the task of lexical translation. We utilize the translation graph, a massive lexical resource where each node denotes a word in some language and each edge denotes a word sense shared by a pair of words. Our current graph contains 1,267,460 nodes and 2,315,783 edges. The graph is automatically constructed from machine-readable dictionaries and Wiktionaries. Paths through the graph suggest word translations absent from any of the input dictionaries. We define a probabilistic inference procedure that enables us to quantify our confidence in a translation derived from the graph, and thus trade precision against recall. We demonstrate the graph’s utility by employing it in the PANIMAGES cross-lingual image search engine. Google retrieves images based on the words in their “vicinity”, which limits the ability of a searcher to retrieve them. Although images are universal, an English searcher will fail to find images tagged in Chinese, and conversely. PANIMAGES addresses this problem by translating and disambiguating queries, using the translation graph, before sending them to Google. Our experiments show that, for queries in “minor” languages, PANIMAGES increases the number of correct images in the first 15 pages of results by 75%.
MAGNETIC INDUCTION HEATING OF FERROMAGNETIC IMPLANTS FOR HYPERTHERMIC TREATMENTS OF CANCER

An experimental system has been developed and tested for inducing hyperthermia by means of ferromagnetic implants. The coil is 60.5 cm in diameter and produces a field strength of 1500 A/m at 93.6 kHz. This is somewhat greater than that required in most clinical situations, but it provides the opportunity to study experimentally optimal characteristics. The operating characteristics of the system are given, as well as the thermal characteristics of the thermally regulating ferromagnetic materials. Methods for calibrating the heating characteristics of the seeds are described, and the results of phantom and animal trials are presented. This system is ready to be introduced into the human clinic.
Optimal Control of a Large Dam

A large dam model is the object of study of this paper. The parameters L lower and L upper define its lower and upper levels, L = L upper - L lower is large, and if the current level of water is between these bounds, the dam is assumed to be in a normal state. Passage across one or other of the levels leads to damage. Let J 1 and J 2 denote the damage costs of crossing the lower and, respectively, the upper levels. It is assumed that the input stream of water is described by a Poisson process, while the output stream is state dependent. Let L t denote the dam level at time t, and let p 1 = lim t→∞P{L t = L lower} and p 2 = lim t→∞P{L t > L upper} exist. The long-run average cost, J = p 1 J 1 + p 2 J 2, is a performance measure. The aim of the paper is to choose the parameter controlling the output stream so as to minimize J.
Religiousness and depression: evidence for a main effect and the moderating influence of stressful life events.

The association between religiousness and depressive symptoms was examined with meta-analytic methods across 147 independent investigations (N = 98,975). Across all studies, the correlation between religiousness and depressive symptoms was -. 096, indicating that greater religiousness is mildly associated with fewer symptoms. The results were not moderated by gender, age, or ethnicity, but the religiousness-depression association was stronger in studies involving people who were undergoing stress due to recent life events. The results were also moderated by the type of measure of religiousness used in the study, with extrinsic religious orientation and negative religious coping (e.g., avoiding difficulties through religious activities, blaming God for difficulties) associated with higher levels of depressive symptoms, the opposite direction of the overall findings.
Helicobacter pylori comb. nov. Exhibits Facultative Acidophilism and Obligate Microaerophilism

Modified brucella broth medium was used to study the growth of Helicobacter pylori at varied pHs and partial pressures of oxygen and to determine the effect of urea on culture pH. Our findings suggested that the pHs of the media remained stable with or without urea and that H. pylori showed facultative acidophilism and obligate microaerophilism.
Mouse Senile Amyloid Fibrils Deposited in Skeletal Muscle Exhibit Amyloidosis-Enhancing Activity

Amyloidosis describes a group of protein folding diseases in which amyloid proteins are abnormally deposited in organs and/or tissues as fine fibrils. Mouse senile amyloidosis is a disorder in which apolipoprotein A-II (apoA-II) deposits as amyloid fibrils (AApoAII) and can be transmitted from one animal to another both by the feces and milk excreted by mice with amyloidosis. Thus, mouse AApoAII amyloidosis has been demonstrated to be a “transmissible disease”. In this study, to further characterize the transmissibility of amyloidosis, AApoAII amyloid fibrils were injected into transgenic Apoa2cTg+/− and normal R1.P1-Apoa2c mice to induce AApoAII systemic amyloidosis. Two months later, AApoAII amyloid deposits were found in the skeletal muscles of amyloid-affected mice, primarily in the blood vessels and in the interstitial tissues surrounding muscle fibers. When amyloid fibrils extracted from the skeletal muscles were subjected to Western blot analysis, apoA-II was detected. Amyloid fibril fractions isolated from the muscles not only demonstrated the structure of amyloid fibrils but could also induce amyloidosis in young mice depending on its fibril conformation. These findings present a possible pathogenesis of amyloidosis: transmission of amyloid fibril conformation through muscle, and shed new light on the etiology involved in amyloid disorders.
Bisphosphonate Therapy Ameliorates Hearing Loss in Mice Lacking Osteoprotegerin

Three auditory ossicles including the malleus, incus, and stapes conduct sound in the middle ear from the tympanic membrane to the inner ear. Auditory ossicles are massively resorbed by osteoclasts in Opg−/− mice, which lack osteoprotegerin (OPG), a soluble decoy receptor for the osteoclastogenic cytokine RANKL. Opg−/− mice exhibit progressive hearing loss and are a model for juvenile Paget's disease. However, effects of antiresorptive treatment on auditory ossicles and on hearing function in Opg−/− mice are unknown. We intraperitoneally injected Opg−/− mice with bisphosphonate risedronate 5 d/wk for 9 wk. Morphology of auditory ossicles was examined microscopically, radiographically, and histologically. Hearing function was monitored by measuring the auditory brain stem response (ABR). Control Opg−/− mice exhibited thinning of all three ossicles and tibia. In contrast, risedronate treatment significantly inhibited bone loss in auditory ossicles as well as in long bones of Opg−/− mice. Bony fusion of the junction between the stapes and the otic capsule was reduced after treatment. Moreover, ABR measurement showed that hearing in Opg−/− mice was significantly improved by risedronate treatment. These data suggest that hearing loss in pathologies characterized by excessive resorption of the auditory ossicles may be prevented by bisphosphonates.
Anthropometric fractionation of body mass: Matiegka revisited

In a group of 699 Belgian nursing professionals, we estimated body composition using the four-component anthropometric model, relying on the equations originally formulated by Matiegka in 1921 and later revised by Drinkwater and colleagues. We estimated muscle mass using the more recent formula proposed by Martin and co-workers. A discrepancy was noted between estimated total body mass and 'assessed' mass, suggesting erroneous estimations of the components.