Miracle-dz/UniFAR-FTUs huggingface dataset:
Paranoia and conspiracy: group cohesion increases harmful intent attribution in the Trust Game

Current theories argue that hyper-sensitisation of social threat perception is central to paranoia. Affected people often also report misperceptions of group cohesion (conspiracy) but little is known about the cognitive mechanisms underpinning this conspiracy thinking in live interactions. In a pre-registered experimental study, we used a large-scale game theory approach (N > 1,000) to test whether the social cohesion of an opposing group affects paranoid attributions in a mixed online and lab-based sample. Participants spanning the full population distribution of paranoia played as proposers in a modified Trust Game: they were allocated a bonus and chose how much money to send to a pair of responders which was quadrupled before reaching these responders. Responders decided how much to return to the proposers through the same process. Participants played in one of two conditions: against a cohesive group who communicated and arrived at a joint decision, or a non-cohesive group who made independent decisions. After the exchange, proposers rated the extent to which the responders’ decisions were driven by (i) self-interest and (ii) intent to harm. Although the true motives are ambiguous, cohesive responders were reliably rated by participants as being more strongly motivated by intent to harm, indicating that group cohesion affects social threat perception. Highly paranoid participants attributed harmful intent more strongly overall but were equally reactive to social cohesion as other participants. This suggests that paranoia involves a generally lowered threshold for social threat detection but with an intact sensitivity for cohesion-related group characteristics.
Winds and infalling gas in Lyman break galaxies

A model for gas outflows is proposed which simultaneously explains the correlations between the (i) equivalent widths of low-ionization and Lya lines, (ii) outflow velocity, and (iii) star formation rate observed in Lyman break galaxies (LBGs). Our interpretation implies that LBGs host short-lived (30 ± 5 Myr) starburst episodes observed at different evolutionary phases. Initially, the starburst powers a hot wind bound by a denser cold shell, which after ≈5 Myr becomes dynamically unstable and fragments; afterwards the fragment evolution is approximately ballistic while the hot bubble continues to expand. As the fragments are gravitationally decelerated, their screening ability of the starlight decreases as the ultraviolet (UV) starburst luminosity progressively dims. LEG observations sample all these evolutionary phases. Finally, the fragments fall back on to the galaxy after ≈60 Myr. This phase cannot be easily probed as it occurs when the starburst UV luminosity has already largely faded; however, galaxies dimmer in the UV than LBGs should show infalling gas.
Novel Photosensitizers Trigger Rapid Death of Malignant Human Cells and Rodent Tumor Transplants via Lipid Photodamage and Membrane Permeabilization

Background Apoptotic cascades may frequently be impaired in tumor cells; therefore, the approaches to circumvent these obstacles emerge as important therapeutic modalities. Methodology/Principal Findings Our novel derivatives of chlorin e6, that is, its amide (compound 2) and boronated amide (compound 5) evoked no dark toxicity and demonstrated a significantly higher photosensitizing efficacy than chlorin e6 against transplanted aggressive tumors such as B16 melanoma and M-1 sarcoma. Compound 5 showed superior therapeutic potency. Illumination with red light of mammalian tumor cells loaded with 0.1 µM of 5 caused rapid (within the initial minutes) necrosis as determined by propidium iodide staining. The laser confocal microscopy-assisted analysis of cell death revealed the following order of events: prior to illumination, 5 accumulated in Golgi cysternae, endoplasmic reticulum and in some (but not all) lysosomes. In response to light, the reactive oxygen species burst was concomitant with the drop of mitochondrial transmembrane electric potential, the dramatic changes of mitochondrial shape and the loss of integrity of mitochondria and lysosomes. Within 3–4 min post illumination, the plasma membrane became permeable for propidium iodide. Compounds 2 and 5 were one order of magnitude more potent than chlorin e6 in photodamage of artificial liposomes monitored in a dye release assay. The latter effect depended on the content of non-saturated lipids; in liposomes consisting of saturated lipids no photodamage was detectable. The increased therapeutic efficacy of 5 compared with 2 was attributed to a striking difference in the ability of these photosensitizers to permeate through hydrophobic membrane interior as evidenced by measurements of voltage jump-induced relaxation of transmembrane current on planar lipid bilayers. Conclusions/Significance The multimembrane photodestruction and cell necrosis induced by photoactivation of 2 and 5 are directly associated with membrane permeabilization caused by lipid photodamage.
When opportunity knocks, who answers? Infidelity, gender, race, and occupational sex composition

Correspondence Christin L. Munsch, Department of Sociology, University of Connecticut, Storrs, CT. Email: christin.munsch@uconn.edu To date, the prevailing explanation for gender differences in infidelity has been evolutionary. Adaptive pressures lead men to seek sexual variety and, consequently, take advantage of opportunities for extramarital sex more than women. However, an often-overlooked component of the evolutionary perspective is the way in which social context influences behavior. Thus, we extend previous theoretical accounts by examining the ways in which opportunity is facilitated or constrained by experiences of tokenism. The authors find, for White men, who tend to report favorable treatment in female-dominated work, opportunity is positively associated with infidelity. For non-White men, who report poor treatment in femaledominated work, occupational sex composition and infidelity are negatively associated. For White and non-White women, occupational sex composition is unrelated to infidelity.
The Dependence of the Occupation of Galaxies on the Halo Formation Time

We study the dependence of the galaxy contents within halos on the halo formation time using two galaxy formation models, one being a semianalytic model utilizing the halo assembly history from a high-resolution N-body simulation and the other being a smoothed particle hydrodynamics simulation including radiative cooling, star formation, and energy feedback from galactic winds. We confirm the finding by Gao et al. that at fixed mass, the clustering of halos depends on the halo formation time, especially for low-mass halos. This age dependence of halo clustering makes it desirable to study the correlation between the occupation of galaxies within halos and the halo age. We find that, in halos of fixed mass, the number of satellite galaxies has a strong dependence on halo age, with fewer satellites in older halos. The youngest one-third of the halos can have an order of magnitude more satellites than the oldest one-third. For central galaxies, in halos that form earlier, they tend to have more stars and thus appear to be more luminous, and the dependence of their luminosity on halo age is not as strong as that of stellar mass. The results can be understood through the star formation history in halos and the merging of satellites onto central galaxies. The age dependence of the galaxy contents within halos would constitute an important ingredient in a more accurate halo-based model of galaxy clustering.
RRAM-Based Analog Approximate Computing

Approximate computing is a promising design paradigm for better performance and power efficiency. In this paper, we propose a power efficient framework for analog approximate computing with the emerging metal-oxide resistive switching random-access memory (RRAM) devices. A programmable RRAM-based approximate computing unit (RRAM-ACU) is introduced first to accelerate approximated computation, and an approximate computing framework with scalability is then proposed on top of the RRAM-ACU. In order to program the RRAM-ACU efficiently, we also present a detailed configuration flow, which includes a customized approximator training scheme, an approximator-parameter-to-RRAM-state mapping algorithm, and an RRAM state tuning scheme. Finally, the proposed RRAM-based computing framework is modeled at system level. A predictive compact model is developed to estimate the configuration overhead of RRAM-ACU and help explore the application scenarios of RRAM-based analog approximate computing. The simulation results on a set of diverse benchmarks demonstrate that, compared with a x86-64 CPU at 2 GHz, the RRAM-ACU is able to achieve 4.06-196.41× speedup and power efficiency of 24.59-567.98 GFLOPS/W with quality loss of 8.72% on average. And the implementation of hierarchical model and X application demonstrates that the proposed RRAM-based approximate computing framework can achieve 12.8× power efficiency than its pure digital implementation counterparts (CPU, graphics processing unit, and field- programmable gate arrays).
The Jet and the Supernova in GRB 990712

The optical light curve of the afterglow following the gamma-ray burst GRB 990712 is reexamined. Recently published polarization measurements of that source require a collimated outflow geometry that in turn predicts a break in the light curve. We show that the V-band light curve is consistent with such a break and that the postbreak light-curve evolution is dominated by a supernova contribution.
House Prices, Consumption, and Monetary Policy: A Financial Accelerator Approach

There is a live debate about the role of house prices in the transmission mechanism of monetary policy. Do house prices merely reflect macroeconomic conditions, or are there important feedback effects from house prices to other economic variables? A general equilibrium model is considered, where asymmetric information problems create frictions in credit markets used by households. In particular, the financial accelerator mechanism of Bernanke, Gertler and Gilchrist is applied to the household sector. In the economy modelled, houses serve two purposes: they provide a stream of housing services to consumers, and they serve as collateral to lower the agency costs related to borrowing. It is shown that under certain conditions this amplifies and propagates the effect of monetary policy shocks on housing investment, house prices and consumption. The effect of a structural change in credit markets that lowers the transaction costs of additional borrowing against housing equity is also considered. It is shown that such a change would increase the effect of monetary policy shocks on consumption, but would decrease the effect of monetary policy shocks on house prices and housing investment.
Coniochaeta prunicola — first record for Slovakia and Europe

This study reports the first record of Coniochaeta on Laurocerasus officinalis Roem. from the Nitra district. This is the first record of Coniochaeta for Slovakia and also for Europe. The fungus Coniochaeta prunicola Damm & Crous (Coniochaetales, Sordariomycetes, Ascomycota) was isolated from damaged leaves and twigs of host trees. Morphological analyses demonstrate that Coniochaeta prunicola and Coniochaeta velutina are distinct species.
Diffusion-Convolutional Neural Networks

We present diffusion-convolutional neural networks (DCNNs), a new model for graph-structured data. Through the introduction of a diffusion-convolution operation, we show how diffusion-based representations can be learned from graph-structured data and used as an effective basis for node classification. DCNNs have several attractive qualities, including a latent representation for graphical data that is invariant under isomorphism, as well as polynomial-time prediction and learning that can be represented as tensor operations and efficiently implemented on the GPU. Through several experiments with real structured datasets, we demonstrate that DCNNs are able to outperform probabilistic relational models and kernel-on-graph methods at relational node classification tasks.
Automatic calibration of damping layers in finite element time domain simulations

Matched layers are commonly used in numerical simulations of wave propagation to model (semi-)infinite domains. Attenuation functions describe the damping in layers, and provide a matching of the wave impedance at the interface between the domain of interest and the absorbing region. Selecting parameters in the attenuation functions is non-trivial. In this work, an optimisation procedure for automatically calibrating matched layers is presented. The procedure is based on solving optimisation problems constrained by partial differential equations with polynomial and piecewise-constant attenuation functions. We show experimentally that, for finite element time domain simulations, piecewise-constant attenuation function are at least as efficient as quadratic attenuation functions. This observation leads us to introduce consecutive matched layers as an alternative to perfectly matched layers, which can easily be employed for problems with arbitrary geometries. Moreover, the use of consecutive matched layers leads to a reduction in computational cost compared to perfectly matched layers. Examples are presented for acoustic, elastodynamic and electromagnetic problems. Numerical simulations are performed with the libraries FEniCS/DOLFIN and dolfin-adjoint, and the computer code to reproduce all numerical examples is made freely available.
New cosine similarity scorings to implement gender-independent speaker verification

This paper is a natural extension of our previous work on gender-independent speaker verification systems [1]. In a previous paper, we presented a solution to avoid using gender information in the Probabilistic Linear Discriminant Analysis (PLDA) without any loss of accuracy compared with a genderdependent base-line implementation. In this work, we propose two solutions to make a speaker verification system based on Cosine similarity independent of speaker gender. Our choice of the Cosine similarity is motivated by the fact that it is proved itself as a second state-of-the art - in parallel with PLDA- of i-vector based speaker verification systems. As measured by Equal Error Rate and min DCF’s, performance results on the extended telephone list coreext-coreext condition of SRE2010 1 show no performance decrease in
The Direct Relationship between Inhibitory Currents and Local Field Potentials

The frequency profiles of various extracellular field oscillations are known to reflect functional brain states, yet we lack detailed explanations of how these brain oscillations arise. Of particular clinical relevance are the high-frequency oscillations (HFOs) associated with interictal events and the onset of seizures. These time periods are also when pyramidal firing appears to be vetoed by high-frequency volleys of inhibitory synaptic currents, thereby providing an inhibitory restraint that opposes epileptiform spread (Trevelyan et al., 2006, 2007). The pattern and timing of this inhibitory volley is suggestive of a causal relationship between the restraint and HFOs. I show that at these times, isolated inhibitory currents from single pyramidal cells have a similarity to the extracellular signal that significantly exceeds chance. The ability to extrapolate from discrete currents in single cells to the extracellular signal arises because these inhibitory currents are synchronized in local populations of pyramidal cells. The visibility of these inhibitory currents in the field recordings is greatest when local pyramidal activity is suppressed: the correlation between the inhibitory currents and the field signal becomes worse when local activity increases, suggestive of a switch from one source of HFO to another as the restraint starts to fail. This association suggests that a significant component of HFOs reflects the last act of defiance in the face of an advancing ictal event.
The Effects of Sex-Ratio and Density on Locomotor Activity in the House Fly, Musca domestica

Abstract Although locomotor activity is involved in almost all behavioral traits, there is a lack of knowledge on what factors affect it. This study examined the effects of sex—ratio and density on the circadian rhythm of locomotor activity of adult Musca domestica L. (Diptera: Muscidae) using an infra—red light system. Sex—ratio significantly affected locomotor activity, increasing with the percentage of males in the vials. In accordance with other studies, males were more active than females, but the circadian rhythm of the two sexes was not constant over time and changed during the light period. There was also an effect of density on locomotor activity, where males at intermediate densities showed higher activity. Further, the predictability of the locomotor activity, estimated as the degree of autocorrelation of the activity data, increased with the number of males present in the vials both with and without the presence of females. Overall, this study demonstrates that locomotor activity in M. domestica is affected by sex—ratio and density. Furthermore, the predictability of locomotor activity is affected by both sex—ratio, density, and circadian rhythm. These results add to our understanding of the behavioral interactions between houseflies and highlight the importance of these factors when designing behavioral experiments using M. domestica.
Hypermethylation of mitochondrial transcription factor A induced by cigarette smoke is associated with chronic obstructive pulmonary disease

Abstract Purpose of the study: Cigarette smoking is a leading environmental contributor to chronic obstructive pulmonary disease (COPD), but its epigenetic regulation of mtTFA gene remains elusive. This study aims to explore the relationship of DNA methylation of mtTFA and cigarette smoking in COPD. Materials and Methods: We analyzed DNA methylation on mtTFA promoters in clinical samples from COPD patients and subjects with normal pulmonary function. Expression of mtTFA mRNA in the clinical samples and mtTFA mRNA and protein in human umbilical vein endothelial cells(HUVECs) treated with cigarette smoke extract (CSE) was evaluated. mtTFA mRNA and protein levels were measured to determine effects of demethylation agents on CSE-treated HUVECs. Results: The DNA methylation level of the mtTFA promoter was significantly increased in COPD group. Expression of mtTFA mRNA was downregulated in the lungs as a consequence of hypermethylation of mtTFA promoter. Expression of mtTFA mRNA and protein was downregulated in CSE-treated HUVECs as a consequence of hypermethylation of the mtTFA promoter. mtTFA expression in CSE-treated HUVECs was restored by the methylation inhibitor, 5-aza-2’-deoxycytidine(AZA). Conclusions: Cigarette smoke-induced hypermethylation of the mtTFA promoter is related to the initiation and progression of COPD. Our finding may provide a new strategy for the intervention of COPD by developing demethylation agents targeting mtTFA hypermethylation.
A Survey of Antimicrobial Stewardship Programs in Korea, 2015

The study was conducted to evaluate the Antibiotic Stewardship Program (ASP) in Korean hospitals compared with the previous two surveys in 2006 and 2012. The information on ASPs was collected through an online-based survey sent by e-mail to 192 infectious diseases specialists in 101 Korean hospitals in September 2015. Fifty-four hospitals (53.5%, 54/101) responded to the online survey. One infectious diseases specialist was employed in 30 (55.6%) of the 54 hospitals, and they were in charge of ASPs in hospitals with the program. Fifty of the 54 hospitals (92.6%) had ASPs and the same number of hospitals was conducting a preauthorization-of-antibiotics-use program. Although most hospitals adopted preauthorization strategies for more antibiotics in 2015 than in 2012 (median 14 in 2015; 13 in 2012), a limited number of antibiotics were under control. The number of per oral and parenteral antibiotics available in hospitals in 2015 decreased compared to 2006 and 2012. The number of hospitals performing a retrospective or prospective qualitative drug use evaluation of antibiotic use increased from 2006 to 2015. Manpower in charge of antibiotic stewardship in most hospitals was still very limited and ASPs heavily depended on preauthorization-of-antibiotics-use programs in this survey. In conclusion, there leaves much to be desired in ASPs in Korea in 2015.
The minimum data set prevalence of restraint quality indicator: does it reflect differences in care?

PURPOSE This study investigated whether the use of restraining devices and related measures of care quality are different in nursing homes that score in the upper and lower quartiles on the Minimum Data Set (MDS) "prevalence of restraint" quality indicator, which assesses daily use of restraining devices when residents are out of bed. DESIGN AND METHODS The study was a cross-sectional study, with 413 residents in 14 nursing facilities. Eight homes scored in the lower quartile (25th percentile; low prevalence, 0-5%) on the MDS restraint prevalence quality indicator, and six homes scored in the upper quartile (75th percentile; high prevalence, 28-48%). Eight care processes related to the management of restraints and gait and balance problems were defined and operationalized into clinical indicators. Research staff conducted direct observations during three 12-hr days (7 a.m.-7 p.m.) to determine the prevalence of restraining devices and identify resident and staff behaviors that may be affected by restraint use. RESULTS Residents in high-restraint homes were in bed during the day on more observations than residents in low-restraint homes (44% vs. 33%; p <.001), were more frequently observed with bed rails in use (74% of residents vs. 64% of residents; p <.03), and received less feeding assistance during meals (2.7 min vs. 4.1 min; p <.001). There were no differences between homes in the use of out-of-bed restraints, nor were there any differences on any care process measure related to the management of restraints, gait and balance problems, or measures of physical or social activity. IMPLICATIONS A home's score on the MDS-generated prevalence of restraint quality indicator was not associated with differences in the use of restraints, physical activity, or any care process measure when residents were out of bed. However, there were differences in the use of in-bed restraining devices, and residents in high-restraint homes were in bed more often during the day. These differences were associated with poor feeding assistance and reflect important differences in quality of care between homes, even though these differences are not what the restraint prevalence quality indicator purports to measure. Methods to monitor and improve the quality of care related to exercise, in-bed times, and resident freedom of movement are discussed.