Miracle-dz/UniFAR-FTUs huggingface dataset:
Fetal ductus venosus flow velocity waveforms and maternal serum afp before and after first‐trimester transabdominal chorionic villus sampling

Doppler flow velocity waveform recording in the fetal ductus venosus and umbilical artery as well as maternal blood sampling for serum alpha‐fetoprotein (MSAFP) was performed before and after transabdominal chorion villus sampling (TACVS) in 36 women of advanced maternal age (≥ 36 years). Gestational age ranged between 11 and 13 weeks. No chromosomal anomaly was detected. No statistically significant difference was observed in ductus venosus velocity parameters or in the umbilical artery pulsatility index (PI) before and after CVS in 35 women with a normal pregnancy outcome. One case resulted in fetal loss. Post‐CVS median MSAFP levels at 12 weeks (25 kIU/1) and 13 weeks (35 kIU/1) were significantly higher than pre‐CVS levels. In three cases, post‐CVS MSAFP levels were higher than 600 kIU/1, correlating with feto‐maternal transfusions of approximately 1.0–1.4 ml, i.e., of around 40 per cent of feto‐placental blood volume. One of these cases displayed absence of fetal peripheral blood flow velocities and fetal bradycardia following TACVS, resulting in fetal loss 1 week later. The remaining two cases had a normal pregnancy outcome, but showed a more than 50 per cent reduction in ductus venosus velocity after TACVS, whereas umbilical artery PI remained unchanged. However, similar velocity changes were associated with only small feto‐maternal transfusions. Umbilical artery PI values remained unchanged.
Chinese hamster ovary cell lysosomes rapidly exchange contents

We have used cell fusion to address the question of whether macromolecules are rapidly exchanged between lysosomes. Donor cell lysosomes were labeled by the long-term internalization of the fluid- phase pinocytic markers, invertase (sucrase), Lucifer Yellow, FITC- conjugated dextran, or Texas red-conjugated dextran. Recipient cells contained lysosomes swollen by long-term internalization of dilute sucrose or marked by an overnight FITC-dextran uptake. Cells were incubated for 1 or 2 h in marker-free media before cell fusion to clear any marker from an endosomal compartment. Recipient cells were infected with vesicular stomatitis virus as a fusogen. Donor and recipient cells were co-cultured for 1 or 2 h and then fused by a brief exposure to pH 5. In all cases, extensive exchange of content between donor and recipient cell lysosomes was observed at 37 degrees C. Incubation of cell syncytia at 17 degrees C blocked lysosome/lysosome exchange, although a "priming" process(es) appeared to occur at 17 degrees C. The kinetics of lysosome/lysosome exchange in fusions between cells containing invertase-positive lysosomes and sucrose-positive lysosomes indicated that lysosome/lysosome exchange was as rapid, if not more rapid, than endosome/lysosome exchange. These experiments suggest that in vivo the lysosome is a rapidly intermixing organellar compartment.
Recombination and Linkage Disequilibrium Among Mitochondrial Genes in Structured Populations of the Gynodioecious Plant Silene vulgaris

Abstract The impact of intergenic recombination on the population genetics of plant mitochondrial genomes is unknown. In an effort to study this in the gynodioecious plant Silene vulgaris three-locus PCR/RFLP genotypes (based on the mitochondrial genes atpA, cox1, and cob) were determined for 239 individuals collected from 20 North American populations. Seventeen three-locus PCR/RFLP genotypes were found. Recombination was indicated by observation of each of the four two-locus genotypes possible when the two most common alleles are considered for each of two loci. Based on these common alleles the absolute values of standardized linkage disequilibrium |D′| between pairs of loci range from 0.17 to 0.78. This indicates modest disequilibrium, rather than the maximum value expected in the absence of recombination |D′= 1|, or the linkage equilibrium expected if recombination is pervasive (D′= 0). Values of D′ did not depend on which pair of loci contributed alleles to the analysis. The direction of D′ obtained for the common atpA and cox1 alleles was comparable in sign and magnitude to that obtained by examining similar information obtained in a prior study of European samples. All three loci indicated a high degree of population structure (average FST= 0.63), which would limit the within-population genetic diversity required for intergenic recombination to create novel genotypes, if most mating is local. Thus, population structure acts as a constraint on the approach to linkage equilibrium.
Modulation of Lipoprotein Cholesterol Levels in Plasmodium berghei Malarial Infection by Crude Aqueous Extract of Ganoderma lucidum

In this study, attempt is made to establish changes in serum and liver lipoprotein cholesterols accompanying Plasmodium berghei malarial infection in mice treated with aqueous extract of Ganoderma lucidum at 100, 250, and 500 mg/kg body weight in comparison with 15 mg/kg chloroquine (CQ). Significant increases in all the lipoprotein fractions were observed in infected untreated mice compared with normal control mice. Treatment with 100 and 250 mg/kg G. lucidum extract produced significant reduction in serum total cholesterol (TC) and low-density cholesterol (LDL-C) contents compared with 500 mg/kg G. lucidum and CQ. Treatment with CQ, however, produced significant reduction in hepatic TC and LDL-C compared with the extract. A dose-dependent significant increase in serum high-density lipoprotein cholesterol (HDL-C) was observed in the G. lucidum treated mice compared with normal control but significantly lower compared with CQ-treated mice. Liver HDL-C level was significantly higher in CQ-treated mice compared with normal control and significantly lower compared with G. lucidum-treated and infected untreated mice. A dose-dependent effect of the extract was observed in both serum and liver very-low density lipoprotein cholesterol (VLDL-C). The implication of these results is discussed with respect to the parasite survival and proliferation in the serum and liver.
Reading Anomalous Sentences: An Event-Related fMRI Study of Semantic Processing

We report a random-effects analysis of an event-related fMRI study (n = 28) of cerebral activity during the reading of sentences that ended with a word that was either congruent or incongruent with the previous sentence context. Event-related potential studies have shown that this task elicits a late negativity peaking around 400 ms poststimulus (N400) that is larger for incongruent than for congruent sentence endings. A direct comparison of the activation for incongruent words versus that for congruent words revealed significantly greater activation for incongruent words than congruent words in bilateral inferior frontal and inferio-medial temporal cortex, left lateral frontal cortex, left posterior fusiform gyrus, bilateral motor cortex, and supplementary motor area. These results are consistent with data from intracranial electrical recording studies of the N400 electrical potential. The results are discussed as they relate to the localization of the cerebral sites underlying semantic processing in general and the localization of the scalp recorded N400 event-related potential in particular.
CYP1A1 Regulates Breast Cancer Proliferation and Survival

Cytochrome P450-1A1 (CYP1A1) is an extrahepatic phase I metabolizing enzyme whose expression is suppressed under physiologic conditions but can be induced by substrates via the aryl hydrocarbon receptor (AhR). Recent studies have shown that the majority of breast cancer tumors constitutively express CYP1A1. These findings led us to test the hypothesis that CYP1A1 promotes breast cancer progression by evaluating the effects of CYP1A1 knockdown on the proliferation and survival of the MCF7 and MDA-MB-231 lines. Independently of estrogen receptor status, CYP1A1 knockdown decreased colony formation, decreased cell proliferation, blocked the cell cycle at G0-G1 associated with reduction of cyclin D1, and increased apoptosis associated with reduction of survivin. CYP1A1 knockdown markedly increased phosphorylation of AMP-activated protein kinase (AMPK) and decreased phosphorylation of AKT, extracellular signal-regulated kinases 1 and 2 (ERK1/2), and 70-kDa ribosomal protein S6 kinase (P70S6K). AMPK inhibition by compound C partially abrogated the proapoptotic effects of CYP1A1 knockdown, suggesting that effects of CYP1A1 knockdown are mediated in part through AMPK signaling. Consistent with CYP1A1 knockdown, pharmacologic reduction of CYP1A1 levels by the phytopolyphenol carnosol also correlated with impaired proliferation and induced AMPK phosphorylation. These results indicate that reduction of basal CYP1A1 expression is critical for inhibition of proliferation, which is not affected by α-naphthoflavone-mediated inhibition of CYP1A1 activity nor modulated by AhR silencing. This study supports the notion that CYP1A1 promotes breast cancer proliferation and survival, at least in part, through suppression of AMPK signaling and that reduction of CYP1A1 levels is a potential strategy for breast cancer therapeutics. Mol Cancer Res; 11(7); 780–92. ©2013 AACR.
Knowledge Generation Model for Visual Analytics

Visual analytics enables us to analyze huge information spaces in order to support complex decision making and data exploration. Humans play a central role in generating knowledge from the snippets of evidence emerging from visual data analysis. Although prior research provides frameworks that generalize this process, their scope is often narrowly focused so they do not encompass different perspectives at different levels. This paper proposes a knowledge generation model for visual analytics that ties together these diverse frameworks, yet retains previously developed models (e.g., KDD process) to describe individual segments of the overall visual analytic processes. To test its utility, a real world visual analytics system is compared against the model, demonstrating that the knowledge generation process model provides a useful guideline when developing and evaluating such systems. The model is used to effectively compare different data analysis systems. Furthermore, the model provides a common language and description of visual analytic processes, which can be used for communication between researchers. At the end, our model reflects areas of research that future researchers can embark on.
Control of Simultaneous Outbreaks of Carbapenemase-Producing Enterobacteriaceae and Extensively Drug-Resistant Acinetobacter baumannii Infection in an Intensive Care Unit Using Interventions Promoted in the Centers for Disease Control and Prevention 2012 Carbapenemase-Resistant Enterobacteriaceae To

Objective We describe the efficacy of enhanced infection control measures, including those recommended in the Centers for Disease Control and Prevention’s 2012 carbapenem-resistant Enterobacteriaceae (CRE) toolkit, to control concurrent outbreaks of carbapenemase-producing Enterobacteriaceae (CPE) and extensively drug-resistant Acinetobacter baumannii (XDR-AB). Design Before-after intervention study. Setting Fifteen-bed surgical trauma intensive care unit (ICU). Methods We investigated the impact of enhanced infection control measures in response to clusters of CPE and XDR-AB infections in an ICU from April 2009 to March 2010. Polymerase chain reaction was used to detect the presence of bla KPC and resistance plasmids in CRE. Pulsed-field gel electrophoresis was performed to assess XDR-AB clonality. Enhanced infection-control measures were implemented in response to ongoing transmission of CPE and a new outbreak of XDR-AB. Efficacy was evaluated by comparing the incidence rate (IR) of CPE and XDR-AB before and after the implementation of these measures. Results The IR of CPE for the 12 months before the implementation of enhanced measures was 7.77 cases per 1,000 patient-days, whereas the IR of XDR-AB for the 3 months before implementation was 6.79 cases per 1,000 patient-days. All examined CPE shared endemic bla KPC resistance plasmids, and 6 of the 7 XDR-AB isolates were clonal. Following institution of enhanced infection control measures, the CPE IR decreased to 1.22 cases per 1,000 patient-days (P = .001), and no more cases of XDR-AB were identified. Conclusions Use of infection control measures described in the Centers for Disease Control and Prevention’s 2012 CRE toolkit was associated with a reduction in the IR of CPE and an interruption in XDR-AB transmission.
Induced suspicion of deception impairs eyewitnesses' memory of a suspect

THESIS: Induced Suspicion of Deception Impairs Eyewitnesses’ Memory of a Suspect STUDENT: Brittney Klauser DEGREE: Master of Arts COLLEGE: Sciences and Humanities DATE: July, 2013 PAGES: 42 Eyewitnesses to crimes sometimes perform cognitively demanding tasks while simultaneously observing a perpetrator. This division of attentional resources can cause them to remember the perpetrator less accurately. Pickel et al. (in press) showed that judging a target individual’s veracity impairs subsequent memory for his or her appearance and message. They argued that this result occurred because judging veracity is an attention-demanding task that is difficult to perform while simultaneously encoding the target’s information. The previous study also demonstrated that suspicion exaggerated the memory impairment effect, apparently by inducing suspicious witnesses to scrutinize the target more closely than non-suspicious witnesses. The goal of the present study was to replicate the findings that judging veracity impairs witnesses’ memory for the target’s appearance and message using a different video (i.e., a different target, crime scenario, and message) and that induced suspicion exaggerates this effect. In addition, I hypothesized that judging veracity also impairs witnesses’ performance on a lineup task and inflates confidence and ratings on other testimony-relevant judgments by giving witnesses the false sense that they have attended closely to the suspect’s physical appearance and message. I hypothesize that suspicion will exaggerate this effect. Results were found to be consistent with Pickel et al.’s (in press) previous findings. Witnesses who judged veracity performed more poorly on the lineup task than those who were not informed they would need to judge veracity, and witnesses who were made suspicious performed worse than those who judged veracity. Differences were discovered across the groups in relation to certainty ratings and other testimony-relevant judgments about the eyewitness experience.
Culture & mental illness : a client-centered approach

PART I: INTRODUCTION AND THEORETICAL ISSUES 1. Why Culture? 2. Culture and Clinical Reality 3. Culture and Personality 4. Cultural Assessment 5. Client-Centered Treatment PART II: CULTURE AND DSM-IV DIAGNOSES 6. Personality Disorders 7. Sexual and Gender Identity Disorders 8. Eating Disorders 9. Substance-Related Disorders 10. Anxiety Disorders 11. Somatoform Disorders 12. Mood Disorders 13. Dissociative Disorders 14. Psychotic Disorders 15. Toward a Client-Centered Paradigm: A Holistic Synthesis Glossary References Name Index Subject Index
Antibiotic-Associated Hemorrhagic Colitis Caused by Cytotoxin-Producing Klebsiella oxytoca

Klebsiella oxytoca was recently described as the causative organism for antibiotic-associated hemorrhagic colitis (AAHC). It is currently not known if this novel gastrointestinal infection exists in children. AAHC is usually preceded by antibiotic treatment with penicillins, which are frequently prescribed for pediatric patients. In contrast to colitis caused by Clostridium difficile, colitis caused by K oxytoca is usually segmental and located predominantly in the right colon. Patients with AAHC typically present with abdominal pain and almost always bloody diarrhea. We present here the case of an adolescent patient who developed acute abdominal pain and bloody diarrhea after antibiotic treatment for acute urinary infection with amoxicillin-clavulanate. Right-sided colitis was verified by abdominal sonography. Stool culture tested negative for common gastrointestinal pathogens but yielded K oxytoca. Toxin production of the isolated strain was verified in a cell-culture assay. Cessation of the causative antibiotic treatment led to rapid improvement and cessation of bloody diarrhea within 3 days. We report here the first (to our knowledge) pediatric case of K oxytoca infection causing AAHC. Establishing the diagnosis of AAHC by culturing K oxytoca and demonstrating right-sided colitis with noninvasive imaging studies might prevent unnecessary invasive procedures in children with bloody diarrhea.
Predicting best answer using sentiment analysis in community question answering systems

While interests in seeking and sharing questions/ answers through the Community Question Answering (CQA) systems has been increased, predicting the best answer in such systems is one of the main challenges that we are going to tackle in this paper. Considering comments as one of the inputs in our model and extracting features using Natural Language Processing (NLP) and text mining techniques such as Sentiment Analysis (SA) on comments and spell checking for answers, are the main parts of this research. Moreover, we worked on English language websites. On the other hand, users' social behavior and their activities considered as informative features in this paper. As a result, by finding the best combination of different features the performance of our model shows improvement in comparison to the related previous works on "Stack Exchange" websites.
Plyometric training improves power and agility in Jamaica's national netball team.

OBJECTIVE Plyometric training is widely used in conditioning, power training and in prevention and rehabilitation of injuries in some sports. This study sought to investigate the effect of a three-week plyometric training programme on jump performance and agility in Jamaican national netball players. METHOD Eighteen national netballers participated in a Plyometric training programme. Subjects were evaluated using the Vertical Jump Test, the Broad Jump Test and the Illinois Agility Test prior to the start of the programme and at week 3. DATA ANALYSIS The data were analysed using SPSS version 12 for Windows. A One-Sample Kolmogorov-Smirnov Test showed normal distribution of data and a paired samples t-test was used to determine whether the mean change in jump performance and agility was significant. RESULTS All eighteen subjects completed the three weeks of training. Three subjects were shown to be outliers at week 3 and this resulted in data from 15 subjects being analysed. At the end of the three weeks, there were significant improvements in Vertical Jump Scores (p = 0.023), Broad Jump Scores (p = 0.002) and Agility scores (p = 0.045). CONCLUSION Three weeks of Plyometric training can lead to significant improvements in jump performance and agility and should be integrated into the national training programme at intervals yet to be determined.
Digital discourse : language in the new media

Foreword Introduction: Fresh Perspectives on New Media Sociolinguistics PART 1 - METADISCURSIVE FRAMINGS OF NEW MEDIA LANGUAGE 1. Voicing "Sexy Text": Heteroglossia and Erasure in TV News Representations of Detroit's Text Message Scandal 2. WHen Friends Who Talk Stalk Together: Online Gossip as Metacommunication 3. "Join Our Community of Translators": Language Idelogies and Facebook PART 2 - CREATIVE GENRES: TEXTING, MESSAGING AND MULTIMODALITY 4. Beyond Genre: Closings and Relational Work in Text-Messaging 5. Japanese Keitai Novels and Ideologies of Literacy 6. Micro-Blogging and Status Updates on Facebook: Texts and Practices 7. Multimodal Creativity and Identities of Expertise in the Digital Ecology of a World of Warcraft Guild 8. Ride Hard, Live Forever: Translocal Identities in an Online Community of Extreme Sports Chrstians 9. Performing Girlhood Through Typographic Play in Hebrew Blogs PART 4 - STANCE: IDEOLOGICAL POSITION-TAKING AND SOCIAL CATEGORIZATION 10. Stuff White People Like: Stance, Class, Race and Internet Commentary 11. Banal Globalization? Embodied Actions and Mediated Practices in Tourists' Online Photo-Sharing 12. Orienting to Arab Orientalism: Language, Race, and Humor in a YouTube Video PART 5 - NEW PRACTICES, EMERGING METHODOLOGIES 13. From Variation to Heteroglossia in the Study of Computer-Mediated Discourse 14. SMS4science: An International Corpus-Based Texting Project and the Specific Challenges for Multilingual Switzerland 15. C me Sk8: Discourse, Technology and "Bodies Without Organs" Comment Index
Reader Letters to Women's Health Magazines

Women's health magazines emerged as a new cultural industry at the end of the twentieth century, representing a commercial application of the “will to health” developing in neoliberal societies. This paper explores recurring discourses in reader letters published between 1997 and 2000 in two Australian health magazines targeting white, middle-class women. Both GoodMedicine and Nature & Health are engaged in a similar cultural politics, tempting their audiences away from the established women's lifestyle, beauty, and fashion publications by representing health magazine content as natural, practical, and generally “good for you. ” Reader letters published in these magazines deploy the discourses of pragmatism, authenticity, and critical engagement as new cultural imperatives for performing the “normal, healthy woman. ” However, they offer little recognition of the social determinants of health, or the connections between individual practice and global biopolitics. Reader letters inscribe both the successes and failures experienced in performing the “will to health,” and have considerable potential to facilitate new ways of negotiating these cultural imperatives.
Use of palm kernel cake and oil palm by-products in compound feed.

Compound feed is a mixture of feed ingredients obtained from various sources. A feed ingredient is only a constituent of a compound feed and if used as the sole ration fed, has to be enriched further. The composition of a compound feed is determined by three main criteria, i.e. price, nutritional composition and the animal characteristics. The nutritional composition of a compound feed varies depending on the type of livestock to be fed and on their stages of growth. This paper highlights the use of palm kernel cake (PKC) in compound feed for feeding livestock in Malaysia.
Cyclosporin-A-induced prion protein aggresomes are dynamic quality-control cellular compartments

Despite the activity of cellular quality-control mechanisms, subsets of mature and newly synthesized polypeptides fail to fold properly and form insoluble aggregates. In some cases, protein aggregation leads to the development of human neurodegenerative maladies, including Alzheimer's and prion diseases. Aggregates of misfolded prion protein (PrP), which appear in cells after exposure to the drug cyclosporin A (CsA), and disease-linked PrP mutants have been found to accumulate in juxtanuclear deposition sites termed ‘aggresomes’. Recently, it was shown that cells can contain at least two types of deposition sites for misfolded proteins: a dynamic quality-control compartment, which was termed ‘JUNQ’, and a site for terminally aggregated proteins called ‘IPOD’. Here, we show that CsA-induced PrP aggresomes are dynamic structures that form despite intact proteasome activity, recruit chaperones and dynamically exchange PrP molecules with the cytosol. These findings define the CsA–PrP aggresome as a JUNQ-like dynamic quality-control compartment that mediates the refolding or degradation of misfolded proteins. Together, our data suggest that the formation of PrP aggresomes protects cells from proteotoxic stress.