Miracle-dz/UniFAR-FTUs huggingface dataset:
Quality of Life and its Determinants in People Living with Human Immunodeficiency Virus Infection in Puducherry, India

Context: With anti-retroviral therapy (ART) for human immunodeficiency virus infection (HIV) coming into picture, quality of life (QOL) has gained importance. Knowledge on the factors affecting QOL would be helpful in making important policy decisions and health care interventions. Aims: The aim of this study is to assess the quality of life of people living with HIV (PLWH) and to identify the factors influencing their QOL. Materials and Methods: The study was done among 200 PLWH attending a tertiary care hospital, and three Non Governmental Organizations at Puducherry, India, from November 2005 to May 2007. QOL was assessed using HIV specific World Health Organization Quality Of Life scale (WHOQOL-HIV) – BREF questionnaire which has six domains (physical, psychological, level of independence, social relationships, environment and spirituality/religiousness/personal belief). Social support and stigma were measured using “Multidimensional Scale of Perceived Social Support” and “HIV Stigma Scale,” respectively, using Likert Scale. Factors influencing QOL were identified using backward stepwise multiple linear regression with the six domain scores as the dependent variables. Results: Male: Female ratio was 1:1 and 58% were in early stage of the disease (stage I/II). Psychological and SRPB (Spirituality Religiousness and Personal Beliefs) domains were the most affected domains. All the regression models were statistically significant (P<0.05). The determination coefficient was highest for the social relationship domain (57%) followed by the psychological domain (51%). Disease stage and perceived social support significantly influenced all the domains of WHOQOL. Younger age, female gender, rural background, shorter duration of HIV, non-intake of ART and greater HIV related stigma were the high risk factors of poor QOL. Conclusion: Interventions such as ART, family, vocational and peer counseling would address these modifiable factors influencing QOL, thereby improving the QOL of PLWH.
Shape, size and composition dependence of efficiency and dynamics of Förster resonance energy transfer in dye-silica nanoconjugates

The role of relative concentrations of energy donors (fluorescein, D), acceptors (rhodamine, A) and silica on Förster resonance energy transfer (FRET) efficiency and dynamics in dye silica conjugates has been studied, as a part of our initial attempts to ascertain the potential of dye-silica nanoconjugates as light harvesting nanoantennae. Two types of dye-silica nanoconjugates, prepared by the co-condensation method, have been examined. The first is based on silica nanoshells (SNS-dye) while the second is based on silica nanoparticles (SNP-dye). Both these nanostructures have a diameter of approximately 25 nm. Efficient energy transfer (91% and 97%, respectively) has been observed in both, for total fluorophore concentration upto 5–6 mmol, irrespective of the D : A ratio. The lower efficiency at dye concentrations greater than these has been rationalized by the competitive self-quenching of D. A risetime of approximately 500 fs is observed in the A emission in SNS-dye, but there is no such feature in SNP-dye. The shape and size dependence of the FRET efficiency and dynamics has been rationalized as follows: the initial step of dye rich core formation in nanoparticles results in high proximity of dye molecules to each other, leading to highly efficient FRET than in nanoshells. In larger SNP-dye nanoconjugates of 65 nm in diameter, the FRET efficiency decreases to 85%, while a risetime in D emission emerges. This provides support to the proposed correlation between efficiency and packing. Hence, it is inferred that total fluorophore concentration, rather than D : A ratios, governs the FRET dynamics and efficiency in these systems.
Depletion of cardiac catecholamine stores impairs cardiac norepinephrine re-uptake by downregulation of the norepinephrine transporter

In heart failure (HF), a disturbed cardiac norepinephrine (NE) homeostasis is characterized by depleted cardiac NE stores, impairment of the cardiac NE re-uptake by the neuronal norepinephrine transporter (NET) and enhanced cardiac NE net release. Reduced cardiac NE content appears to be caused by enhanced cardiac NE net release from sympathetic neurons in HF, triggered by neurohumoral activation. However, it remains unclear whether reduced NE itself has an impact on cardiac NE re-uptake, independent of neurohumoral activation. Here, we evaluated whether depletion of cardiac NE stores alone can regulate cardiac NE re-uptake. Treatment of Wistar rats with reserpine (5 mg/kg/d) for one (1d) or five days (5d) resulted in markedly reduced cardiac NE content, comparable to NE stores in experimental HF due to pressure overload. In order to assess cardiac NE re-uptake, the specific cardiac [3H]-NE uptake via the NET in a Langendorff preparation was measured. Reserpine treatment led to decreased NE re-uptake at 1d and 5d compared to saline treatment. Expression of tyrosine hydroxylase (TH), the rate-limiting enzyme of the NE synthesis, was elevated in left stellate ganglia after reserpine. Mechanistically, measurement of NET mRNA expression in left stellate ganglia and myocardial NET density revealed a post-transcriptional downregulation of the NET by reserpine. In summary, present data demonstrate that depletion of cardiac NE stores alone is sufficient to impair cardiac NE re-uptake via downregulation of the NET, independent of systemic neurohumoral activation. Knowledge about the regulation of the cardiac NE homeostasis may offer novel therapeutic strategies in HF.
Teacher-Pupil Dialogue in the Guided Reading Session.

Drawing on the findings of an ESRC-funded project, this article concerns the quality of teacher-pupil dialogue in the guided reading session of the Literacy Hour and its relationship to pupils' powers of comprehension. We recorded and analysed examples of discussions during the guided reading session in four primary schools, visiting each of them three times. On each school visit, we recorded the same group of six Year 6 children (10–11-year-olds) working with their class teacher. The results of the study suggest that talk in this context is teacher-dominated. The teacher: usually asks questions to which s/he already knows the answer; normally selects which pupil is going to speak next; keeps a tight grip on the topic of conversation; and does most of the talking. We argue that there is a case for making time available during the guided reading session for a period of discussion in which pupils are invited to play a more leading role in shaping the topic of conversation.
Reconsidering Hispanic Gang Membership and Acculturation in a Multivariate Context

Previous qualitative research has suggested that Hispanic gang membership is linked to the process of acculturation. Specifically, studies have indicated that those who are less assimilated into mainstream American or “Anglo” society are at greater risk for joining gangs. Building on these observations, this study examines the relationship between acculturation and gang membership within a theoretically and empirically informed multivariate framework. Based on a sample of Hispanic adolescents residing in the American Southwest, results largely supported previous qualitative studies that have suggested that a number of factors, including acculturation, are necessary to an understanding of gang membership within this demographic. Findings from logistic regression analyses indicated that respondents’ grade in school, neighborhood drug availability, level of ethnic marginalization, and level of acculturation were all significantly associated with self-reported gang membership. Results also suggested that marginalization may partially mediate the effects of acculturation.
The chief student affairs officer : leader, manager, mediator, educator

Part 1 The chief student affairs officer as campus leader: the evolving complexity of student affairs leadership supporting and assisting the president working with students responding to campus, community, and alumni interests. Part 2 Administrative roles and responsibilities: the manager the mediator the educator. Part 3 Professional concerns and commitments: assessing and developing professional effectiveness student affairs leaders for tomorrow.
Semantic processing and the development of word-recognition skills: Evidence from children with reading comprehension difficulties.

Abstract Children with specific reading comprehension difficulties were compared with control children on tests of language skill. The two groups performed at a similar level on tests requiring predominantly phonological skills, but the poor comprehenders performed less well on tests tapping semantic ability. Although the two groups were matched for decoding ability (as assessed by nonword reading), the poor comprehenders were worse at reading words with irregular spelling patterns and low-frequency words. These results show that despite having adequate phonological decoding skills, poor comprehenders have problems reading words that are typically read with support from semantics. These findings are related to connectionist models of reading development in which phonological and semantic processes interact.
Rewarding prosociality on non-Commercial Online Sharing Platforms

Digitization and new trends in consumption behaviour have brought forward new business models within the Sharing Economy (SE). While commercial online sharing platforms such as Uber and Airbnb have already received some attention by researchers, non-commercial online platforms have remained largely unexplored. At the same time, prosocial motives are playing an increasingly central role in participation in the SE, calling for a better understanding of prosocial factors influencing user behaviour. This paper aims to close this gap by assessing the effect of prosociality, via donation behaviour in previous and current transactions, on the likelihood to make a transaction on non-commercial online sharing platforms. We conduct a controlled online experiment and find a significant increase in transaction likelihood in the presence of prosociality. Users who donated in previous transactions are twice as likely to make a transaction and three times more likely if they donate in current transactions. However, if simultaneously present they crowd each other out, suggesting a potential penalization of excessive prosociality. This paper contributes to the scarce Information Systems (IS) literature on non-commercial online sharing platforms by introducing prosociality as central design feature, and provides valuable insights into designing incentive schemes to foster traffic on online sharing platforms.
Model Selection for Radio Propagation in Suburban Niche with Low Roof Residential Scenario

In the recent times the study of signal propagation models are under continuous reviewand currently a lot of work is being done on prediction of path losses associated with different kinds of environments, but the exactness of each model deployed is valid only for a small frame of fixed parameters which are the fundamentals of it. An exact radio propagation model is important for coping up with new challenges of the field of communication like: appropriate design, deployment, and service management strategies for any wireless network. It thereby becomes important for the purpose of signal coverage prediction, data reception, performance parameters, reception schemes, analysis of signal attenuation under different environments and in determination of the optimum location for the purpose of installation of base stations. Therefore the majorpurpose of this work is to survey various residential path loss prediction models along with few other models and to probe the accuracy of some widely used outdoor propagation models which are applicable for900MHz and 1800 MHz band such as Free space model, Egli model, Okumura model and COST 231 Hata model, ECC model, Bertoni’s model on the interfacial regions of Dehradun. Probing studies requires field measurement which is done in the sub-urbanized zone of the concerned region. Some base stations operating at GSM 1800 MHz band were selected for the measurement in the particular area. Finally the models were verified against the field measurement in order to find out most suitable model for the region.
Comparison of astigmatism following manual small incision cataract surgery: superior versus temporal approach.

INTRODUCTION Now-a-days, all techniques of cataract extraction are meant for giving the best uncorrected visual acuity and early post-operative rehabilitation. PURPOSE To compare astigmatism induced by the superior and temporal section in manual small incision cataract surgery (SICS) in the Indian population. MATERIALS AND METHODS One hundred and ten eyes were taken. Eyes having a steeper vertical keratometry reading were assigned to the superior SICS group whereas eyes with a steeper horizontal keratometry reading were assigned to the temporal SICS group. Eyes with no astigmatism were randomly assigned to either of the two groups. Both the groups had 54 eyes each. Eyes in Group 1 underwent manual SICS with a superior tunnel and eyes in Group 2 underwent manual SICS with a temporal tunnel. The patients were examined on postoperative Day1, 1 week, 45 days, and 3 months. Uncorrected and best-corrected visual acuity was recorded, slit-lamp examination, auto-refracto-meter and keratometry examinations were done. STATISTICS All calculations were performed using surgically-induced astigmatism (SIA) Calculator version 1.0, a free software program. RESULTS In Group 2, only 35 eyes out of 54 completed the follow-up of 90 days. The mean SIA in Group1 was found to be 1.45 +/- 0.7387 and in Group 2 it was 0.75+/- 0.4067. The z score applied was found to be 5.7143. This value was more than the standard value, i.e.2.58. The p value accordingly was less than 0.001, which is highly significant. The SIA induced by the superior incision was 48.28 % more than by the temporal incision. CONCLUSION SICS with the temporal approach provides a better stabilization of the refraction with a significantly less SIA than superior approach.
Correlation Between Change in Air Humidity and the Incidence of Stroke

Introduction: According to the World Health Organization estimates annually in the world die due to CVI every sixth women and 10th man. This paper is the research of the correlation between changes in relative air humidity and stroke (CVA) in the Sarajevo Canton. Included are patients who experienced an acute stroke in the Canton of Sarajevo and treated in the pre hospital phase by the staff of the Institute for Emergency Medicine. Days with stroke and those without cases of stroke were compared within three years and meteorological data for those days were obtained by the Weather Bureau of Federation of Bosnia and Herzegovina. Meteorological data include measurements of average humidity every day at 7, 14 and 21 o’clock in three years. Aim: To evaluate the significance of the influence of humidity on the incidence of CVI’s. Show the trend towards CVI in the reporting period and is it correlated with the trend of change in relative humidity in those days. Correlate the incidence of stroke as determined in relation to gender, age and selected climatic parameter. Material and Methods: This article presents a retrospective study. Subjects were patients of Emergency Medical Care Institute in Sarajevo, which in the period from 2004 to 2006 had a CVI. Included are patients who had a working diagnosis of stroke for the first time or as a repeated stroke. Analysis of cases of stroke was carried out by gender, age, days and seasons by descriptive-analytical epidemiological methods. Results: In total were registered 1930 patients during three years period. According to years of research in 2004–635, 2005-616 and 2006 – 679. It was found that when testing the null hypothesis about the effects of humidity in two months with a maximum stroke in the year and days without CVI and relative humidity only in 2005 had a statistically significant effect on the incidence of stroke, while during the other two years of the study there was no impacts. It turned out that the extreme values of relative humidity of the day whether there was a rapid increase or decrees in humidity increases the incidence of stroke in all three years of research. Conclusion: Patients gender had no effect on the incidence of CVI. Seasons had no effect on the incidence of CVI. Most CVI in all three years of research was in relation to the old age and occurred in the older age group 70-79 (41.35%), where it was shown that the age of the patient influences the incidence of CVI. Extremely low relative humidity and extremely high, influence on the increase in the number of CVI. Determined is a slight correlation between the average relative humidity and CVI in single day.
NXT1, a Novel Influenza A NP Binding Protein, Promotes the Nuclear Export of NP via a CRM1-Dependent Pathway

Influenza remains a serious worldwide public health problem. After infection, viral genomic RNA is replicated in the nucleus and packed into viral ribonucleoprotein, which will then be exported to the cytoplasm via a cellular chromosome region maintenance 1 (CRM1)-dependent pathway for further assembly and budding. However, the nuclear export mechanism of influenza virus remains controversial. Here, we identify cellular nuclear transport factor 2 (NTF2)-like export protein 1 (NXT1) as a novel binding partner of nucleoprotein (NP) that stimulates NP-mediated nuclear export via the CRM1-dependent pathway. NXT1-knockdown cells exhibit decreased viral replication kinetics and nuclear accumulated viral RNA and NP. By contrast, NXT1 overexpression promotes nuclear export of NP in a CRM1-dependent manner. Pull-down assays suggest the formation of an NXT1, NP, and CRM1 complex, and demonstrate that NXT1 binds to the C-terminal region of NP. These findings reveal a distinct mechanism for nuclear export of the influenza virus and identify the NXT1/NP interaction as a potential target for antiviral drug development.
Analysis of urine cytology at a community hospital.

BACKGROUND To review the pattern of urine cytology in our setting of a community hospital with age and gender distribution. Also to discuss the importance of this safe and inexpensive tool for diagnosing and screening urothelial cancers. We desire to encourage more wider and confident use of urine cytology in the routine practice. METHOD We reviewed all the consecutive urine cytology specimens received at our institution during time frame of one year. The cytological diagnosis were grouped in four categories; 1: negative, benign or reactive cases; 2: cases showing acute inflammatory changes; 3: inconclusive cases and 4: malignant cases. Only the positive malignant cases were followed histologically to determine the accuracy and efficiency of urine cytological examination for positive cases. RESULTS A total of 1957 consecutive urine cytology specimens were reviewed. Majority of the cases were negative for tumour (67.19%). The most common diagnostic category was acute inflammatory case (17.3%) while inconclusive cases constituted 11.39% of total. There were 23 (1.18%) positive cases that were diagnosed malignant on urine cytology. These 23 malignant cases were followed histologically and 22 (95.6%) cases turned out to be malignant. CONCLUSION Urine cytological examination is an efficient tool that has a good diagnostic yield in detecting malignant urothelial lesions. It should be used routinely for diagnosing, screening and for follow-up of all malignant urothelial lesions.
Integration of Tone Related Features for Mandarin Speech Recognition by a One-Pass Search Algorithm

How to model Chinese tones and integrate them into an HMM-based recognizer for Chinese recognition has been an area of interest to researchers. In this paper, we propose the use of a polynomial trajectory model to represent pitch shape. We further propose an efficient one-pass search approach that integrates the tone likelihood into the Viterbi search procedure. We report a number of experimental results on tone classification and tonal syllable recognition in the 863 corpus. While the improvement in the tonal syllable accuracy is small, it nevertheless shows the feasibility of the proposed approaches.
Accuracy and acceptability of the 6-day Enlite continuous subcutaneous glucose sensor.

OBJECTIVE This study evaluated the performance and acceptability of the Enlite(®) glucose sensor (Medtronic MiniMed, Inc., Northridge, CA). SUBJECTS AND METHODS Ninety adults with type 1 or type 2 diabetes wore two Enlite sensors on the abdomen and/or buttock for 6 days and calibrated them at different frequencies. On Days 1, 3, and 6, accuracy was evaluated by comparison of sensor glucose values with frequently sampled plasma glucose values collected over a 12-h period. Accuracy was assessed at different reference glucose concentrations and during times when absolute glucose concentration rates of change were <1, 1-2, and >2 mg/dL/min. The sensor's ability to detect hypoglycemia or hyperglycemia was evaluated with simulated alerts. Subject satisfaction was evaluated with a 7-point Likert-type questionnaire, with a score of 7 indicating strong agreement. RESULTS With abdomen sensors under actual-use calibration (mean, 2.8 ± 0.9 times/day), the overall mean (median) absolute relative difference (ARD) values between sensor and reference values were 13.6% (10.1%); the corresponding buttock sensor ARD values were 15.5% (10.5%). With abdomen sensors under minimal calibration (mean, 1.2 ± 0.9 times/day), the mean (median) ARD values were 14.7% (10.8%). Mean ARD values of abdomen sensors at rates of change of <1, 1-2, and >2 mg/dL/min were 13.6%, 12.9%, and 16.3%, respectively. With abdomen sensors, 79.5% and 94.1% of hypoglycemic and hyperglycemic events, respectively, were correctly detected; 81.9% and 94.9% of hypoglycemic and hyperglycemic alerts, respectively, were confirmed. The failure rates for abdomen and buttock sensors were 19.7% and 13.9%, respectively. Mean responses to survey questions for all subjects related to comfort and ease of use were favorable. CONCLUSIONS The Enlite sensor provided accurate data at different glucose concentrations and rates of change. Subjects found the sensor comfortable and easy to use.
Anthropometric assessment of Premiership soccer players in relation to playing position

Abstract A squad of Premiership soccer players (n=24) provided informed consent to participate in this study. Using ISAK (International Society of Advancement of Kinanthropometry) accredited methods, a total of 39 measurements (sectioned as: skinfolds, girths, lengths, and breadths) were made for each player. The procedure involved three measures at each site to calculate a mean value and an acceptable technical error margin. All data collection was performed by an ISAK level 3 accredited anthropometrist. The data analysis consisted of demographic and anthropometric data, including fractionation of body mass and estimated body fat from sum of skinfolds. Scaling of the raw data was done by using the phantom strategem to obtain calculated data for inter-player comparison. Mean calculated scores for playing position were obtained. A multivariate analysis of variance revealed no differences between positions (F 15,41.810=0.783, P=0.688). Previous studies have reported heterogeneity between playing positions. However, in this study, stature and body mass were not different between strikers, midfielders, defenders, and goalkeepers. Research has suggested that a soccer player's anthropometric dimensions can be a major determinant for success within a playing position. In this study, within-position variation was quite large in some cases, which could indicate that a team that does not have the opportunity to hand-pick players, based on anthropometric characteristics, may be at a disadvantage.