Miracle-dz/UniFAR-FTUs huggingface dataset:
Bordetella holmesii in Nasopharyngeal Samples from Chilean Patients with Suspected Bordetella pertussis Infection

We read the article of Njamkepo et al. ([5][1]) with great interest. These authors report the finding of Bordetella holmesii DNA in 177 IS 481 -positive nasopharyngeal samples from French patients with suspected pertussis. They performed 4 Bordetella species-specific “in-house” real-time PCRs on
A quantitative model for differential motility of gliomas in grey and white matter

We have extended a mathematical model of gliomas based on proliferation and diffusion rates to incorporate the effects of augmented cell motility in white matter as compared to grey matter. Using a detailed mapping of the white and grey matter in the brain developed for a MRI simulator, we have been able to simulate model tumours on an anatomically accurate brain domain. Our simulations show good agreement with clinically observed tumour geometries and suggest paths of submicroscopic tumour invasion not detectable on CT or MRI images. We expect this model to give insight into microscopic and submicroscopic invasion of the human brain by glioma cells. This method gives insight in microscopic and submicroscopic invasion of the human brain by glioma cells. Additionally, the model can be useful in defining expected pathways of invasion by glioma cells and thereby identify regions of the brain on which to focus treatments.
A Pass‐Through Revival

type="main"> It has been found that the pass-through of the exchange rate and import prices to domestic prices has weakened over time. The most recent research, however, shows that this trend may have been reversed. Recent studies have applied various time series methods to the Japanese data, and estimated responses of domestic prices to the exchange rate and import prices in different time periods. Those studies have found signs that pass-through has made an impressive comeback since the early 2000s. This paper reviews the most recent evidence and discusses its policy implications. I argue that the exchange rate has likely regained its status as an important transmission mechanism of monetary policy to domestic prices.
CFO Fiduciary Responsibilities and Annual Bonus Incentives

ABSTRACT We examine how firms design bonus plans of their CFOs. CFOs participate in decision making much like other executives, but they also have significant fiduciary responsibilities for reporting firms' financial results. Responsibility for financial reporting raises the question of whether it is appropriate to pay CFOs annual bonuses contingent on self-reported financial performance. In this paper, we provide a framework that characterizes CFO bonuses as a tradeoff between CFOs' decision-making responsibilities and their fiduciary duties over financial reporting. This framework yields a number of implications that we examine empirically using a proprietary survey of CFO compensation practices of public and private firms. Our main finding shows that from 2003 to 2007 public entities (relative to private entities) reduced the percentage of CFO bonuses contingent on financial performance. We interpret this result as evidence that firms mitigate misreporting practices in part by deemphasizing CFO incentive compensation. Copyright (c), University of Chicago on behalf of the Accounting Research Center, 2009.
Is CAPM a Good Predictor Of Stock Return In The Nigerian Healthcare Stocks

This research is on testing the predictive power of Capital Asset Pricing Model (CAPM) as enunciated by Sharpe (1964) in the determination of the required rates of return of Nigerian healthcare sector stocks that coincides with the actual rates of return. As it were, there is no clear cut understanding on the belief with particular reference to Nigerian healthcare sector stocks. In the light of the above assertion, the objective of this study is to find out the required rate of return of Nigerian healthcare sector stocks from 2000-2012 and compare them with the actual rates of return in the corresponding periods to indentify the valuation status of the stocks. Being an empirical study, analytical research design was adopted. The data used were secondary data, which were collected from the financial statements of the firms, The Nigerian Stock Exchange publications, and Central banks of Nigeria publications. The findings show that the Capital Asset Pricing Model (CAPM) as enunciated by Sharpe (1964) did not give any appropriate forecast of the returns from the healthcare sector stocks throughout the thirteen-year period of study. The CAPM made thirty under-valuations and one hundred and eight overvaluations to make a total of one hundred and thirty-eight misappropriations in the thirteen years period of study in the healthcare sector. Therefore, the Capital Asset Pricing Model (CAPM) is not a good predictor of stock return in the healthcare sector of the Nigerian Stock Exchange. Keywords: historical equity market risk premium, historical equity beta, required rate of return to equity, actual market return, actual stock return.
Family‐Owned Business Succession: The Influence of Pre‐performance in the Nomination of Family and Nonfamily Members: Evidence from Spanish Firms

Although family‐owned business succession has been widely researched, very few studies investigate the relationship between preperformance and succession. Drawing on the agency and the resource‐based view theories, we investigate how previous firm performance may influence the nomination of a family or a nonfamily member to top senior positions. We argue that positive firm performance will lead to the nomination of a family member, while negative firm performance leads to nonfamily nominations. Using a stepwise logistic regression with a bootstrap procedure on a sample of nonfinancial firm listed in the Spanish Stock Exchange, the results indicate that performance prior to succession does not affect these nominations, while directive experience does.
How Productive is Public Capital? A Meta-Regression Analysis

The last two decades have witnessed a great deal of effort devoted to measuring the private output elasticity of public capital, but remarkably little consensus has emerged. This paper estimates the meta-output elasticity of public capital and explains the heterogeneity of primary estimates around this value. We develop a simple approach to measure and correct meta-estimates for bidirectional publication bias. Using meta-regression analysis applied to a sample of 67 studies for the 1983{2008 period, we derive an unconditional meta-output estimate of 0.146 and show that the `true' effect is rather heterogeneous. The intraregional short-run output elasticity amounts to 0.085. In the long run, and after accounting for interregional spillover effects, the contribution of public capital to output increases by a factor of three. The results suggest that the high output elasticities found in the early time-series literature are compatible with long-run (cointegrating) estimates found more recently. We also show that the observed estimates are significantly inflated by bidirectional publication bias.
Matched ventilation, perfusion and chest radiographic abnormalities in acute pulmonary embolism.

UNLABELLED This investigation assessed the positive predictive value of matched ventilation/perfusion (V/Q) and chest radiographic defects (triple-matched defects) for the detection of acute pulmonary embolism (PE). METHODS Data are from the Prospective investigation of Pulmonary Embolism Diagnosis (PIOPED). Only patients randomized for obligatory pulmonary angiography were included. Lungs were excluded if they showed any mismatched V/Q defect or any pleural effusion. RESULTS Positive predictive values of triple-matched defects in the upper plus middle zones, 1 of 27 (4%), were less frequent than in the lower zones, 13 of 57 (23%) (p < 0.05). Triple-matched defects that involved 25-50% of a zone showed PE in 12 of 38 (32%) which was a higher positive predictive value than with smaller or larger triple-matched defects, 2 of 46 (4%) (p < 0.001). CONCLUSION Refinement of the PIOPED data by elimination of nonrandomized patients, elimination of lungs with mismatched perfusion defects and elimination of lungs with a pleural effusion indicate that triple matches with PE (radiographic pulmonary infarcts) are infrequent in the upper and middle lung zones. When a triple match with PE occurs, it is most likely to be 25-50% of a zone.
Effects of polypharmacy on outcome in patients with schizophrenia in routine psychiatric treatment

Längle G, Steinert T, Weiser P, Schepp W, Jaeger S, Pfiffner C, Frasch K, Eschweiler GW, Messer T, Croissant D, Becker T, Kilian R. Effects of polypharmacy on outcome in patients with schizophrenia in routine psychiatric treatment.
Glucocorticosteroids in the treatment of inflammatory bowel disease and approaches to minimizing systemic activity

Inflammatory bowel diseases (IBDs) are a group of inflammatory conditions characterized by chronic, uncontrolled inflammation of the gastrointestinal tract. Reported prevalence is high in the United States and northern Europe, while the incidence varies greatly across the rest of Europe. Glucocorticosteroids are the standard treatment for IBD, but due to adverse events their use can be limited. However, new formulations of glucocorticosteroids have been developed to reduce systemic activation. The aim of this review was to assess and summarize the efficacy and safety of new formulations of glucocorticosteroids. A MEDLINE search identified publications focused on new formulations of nonsystemic steroid-based drugs for IBD and benefits and limitations of each of the new glucocorticosteroid formulations were identified. Budesonide has good efficacy and is an established treatment for Crohn’s disease; it has been shown to be beneficial for the induction of remission in these patients, although it is not recommended for the maintenance of induced remission. Glucocorticosteroids are not recommended for the maintenance of remission in patients with IBD. However, a recent study suggested that beclomethasone dipropionate may be effective for prolonged treatment in patients in the postacute phase of Crohn’s disease who were treated with a short course of systemic steroids. The efficacy of fluticasone propionate and prednisolone metasulphobenzoate in IBD is not well established given the small number of patients enrolled in the few published clinical trials. While the tolerability of these glucocorticosteroids is favourable, more research comparing these new agents with traditional systemic glucocorticosteroids is warranted.
Market condition, number of transactions, and price volatility

Purpose - Taiwan OTC market is an electronic, order driven, call market. The purpose of this paper is to gain understanding of whether trade size or number of transaction provides more information on explaining price volatility and market liquidity in this market. The paper also aims to investigate how market condition can affect the relationship between information type and trading activities. Design/methodology/approach - The paper uses data from the Taiwan OTC market to run the empirical tests. It divides firms into five size groups based on their market capitalization. Regression equations are run to test: whether number of transactions has a more significant impact on price volatility on the Taiwan OTC market; the impact of market information on number of transactions; the relative impact of firm specific and market information on number of transactions; and the impact of number of transaction of bid-ask spread. Findings - Findings show that the larger the number of transactions, the higher the price volatility. Smaller firms on the Taiwan OTC market are traded based on firm-specific information. This relation is further affected by market trends. Especially for the larger firms, when the market is up and the amount of market information increases, number of transactions increases. When the market is down and the amount of market information increases, number of transactions decreases. Finally, it is found spread size is more likely to be influenced by number of transactions, instead of trade size. Overall, based on these empirical results, the information content of number of transactions seems to be higher than that of trade size in the Taiwan OTC market. Practical implications - Investors now understand that number of transaction actually carry more information than trade size does. Originality/value - The relation between market information and number of transaction, also that between market information and trade size is influenced by market condition. The paper fills a gap in the literature to show that market condition has an impact on the relation between information type and trader's behavior. A number of transactions are identified that provide more information than trade size does. It is also shown that market conditions can further affect the impact of information on trading activities.
Fixed vs. Floating Exchange Rates: How Price Setting Affects the Optimal Choice of Exchange-Rate Regime

We investigate the welfare properties of fixed and floating exchange rate regimes in a two-country, dynamic, infinite-horizon model with agents optimizing in an environment of uncertainty created by monetary shocks. The optimal exchange rate regime may depend on whether prices are set in the currency of producers or the currency of consumers. When prices are set in consumers' currency, the variance of home consumption is not influenced by foreign monetary variance under floating exchange rates, while there is transmission of foreign disturbances under floating rates if prices are set in producers' currencies, or under fixed exchange rates. An important feature of the model is the exchange rate regime affects not just the variance of consumption and output, but also their average levels. When prices are set in producer's currency, as in the traditional framework, we find that there is a trade-off between floating and fixed exchange rates. Exchange rate adjustment under floating rates allows for a lower variance of consumption, but exchange rate volatility itself leads to a lower average level of consumption. When prices are set in consumer's currency, floating exchange rates always dominate fixed exchange rates.
Survey of migraine sufferers with dogs to evaluate for canine migraine-alerting behaviors.

OBJECTIVES Anecdotal reports suggest that changes in dog behavior might be used to predict impending migraine episodes. This survey was designed to investigate how companion dogs react to migraines that occur in their owners. DESIGN Online survey was available from January 4-31, 2012. SETTINGS/LOCATION Survey was conducted through SurveyMonkey, with links to the survey posted at Migraine.com and promoted through social media. SUBJECTS Adults ≥18 years old who experience migraine episodes and live with a dog were eligible to participate. INTERVENTIONS AND OUTCOME MEASURES Participants completed an 18-question online survey that asked about participant demographics, migraines, and their dog's behavior before or during migraine episodes. RESULTS The survey was completed by 1029 adult migraineurs (94.9% women), with migraines typically occurring ≤8 days per month in 63.4% of participants. A recognized change in the dog's behavior prior to or during the initial phase of migraine was endorsed by 552 participants (53.7%), most commonly unusual attentiveness to the owner (39.9%). Among the 466 participants providing details about their dog's behavior with their migraines, 57.3% were able to identify dog alerting behavior before symptoms of a migraine attack would typically begin, with changes usually noticed within 2 hours before the onset of initial migraine symptoms. The dog's behavior was considered to be often or usually linked with the development of a migraine for 59.2% of migraineurs, and 35.8% of migraineurs endorsed beginning migraine treatments after the dog's behavior was recognized and before migraine symptoms had started. Participant demographics, migraine frequency, and breed of dog in the home were similar between the 470 participants with no alerting behavior endorsed and the 466 participants providing detailed alerting information. CONCLUSIONS About one in four migraineurs living with a companion dog endorsed recognizing a change in their dog's behavior before recognizing initial symptoms of a migraine attack.
Validity of age at menarche self-reported in adulthood

Objective: To test the validity of age at menarche self-reported in adulthood and examine whether socioeconomic position, education, experience of gynaecological events and psychological symptoms influence the accuracy of recall. Design: Prospective birth cohort study. Setting: England, Scotland and Wales. Participants: 1050 women from the Medical Research Council National Survey of Health and Development, with two measures of age at menarche, one recorded in adolescence and the other self-reported at age 48 years. Results: By calculating the limits of agreement, κ statistic and Pearson’s correlation coefficients (r), we found that the validity of age at menarche self-reported in middle age compared with that recorded in adolescence was moderate (κ = 0.35, r = 0.66, n = 1050). Validity was improved by categorising age at menarche into three groups: early, normal and late (κ = 0.43). Agreement was influenced by educational level and having had a stillbirth or miscarriage. Conclusions: The level of validity shown in this study throws some doubt on whether it is justifiable to use age at menarche self-reported in middle age. It is likely to introduce error and bias, and researchers should be aware of these limitations and use such measures with caution.
A Descriptive Study of Sustainability Education in the Hospitality Curriculum

Abstract This paper focuses on sustainability education in the hospitality curriculum. A survey of 151 educators who were members of the International Council on Hotel, Restaurant, and Institutional Education provided data for the study during the spring of 2008. Results indicated that while sustainability is taught in a variety of ways in hospitality courses it does not appear to be central to the courses and programs of those sampled. Findings suggest that sustainability concepts do not carry great emphasis in hospitality education. Implications are discussed.
Academic Undermatching of High-Achieving Minority Students: Evidence from Race-Neutral and Holistic Admissions Policies†

College is a pathway to social mobility in the United States. Yet too often high-achieving students from low-income and minorities families fail to apply to selective postsecondary institutions. Our study examines the extent to which academic undermatching occurs among high-achieving minority students by analyzing the application choices of students who undergo two distinct admissions policies. We find that minority students eligible for automatic admissions and those who undergo holistic admissions are both less likely to apply to elite flagship universities than white students, despite being equally qualified based on high school performance. Instead, minorities often opt for lower tier universities.
RISK FACTORS FOR PROLIFERATIVE DIABETIC RETINOPATHY IN A LATINO AMERICAN POPULATION

Purpose: To assess the personal and demographic risk factors for proliferative diabetic retinopathy in Latino Americans in Los Angeles County. Methods: In this prospective, non-interventional, cross-sectional case control study, seven hundred and twenty-nine subjects from Los Angeles County University of Southern California Medical Center (LAC + USC), Los Angeles, CA, were enrolled. All patients were recruited prospectively from the LAC + USC Medical Center and affiliated clinics between June 2008 and June 2011. Complete personal data and results from systemic and ophthalmic examinations were collected for all enrolled subjects. Laboratory tests such as glycosylated hemoglobin, creatinine levels, and cholesterol levels were collected prospectively by drawing blood at the time of each patient's clinic visit. The main outcome measures were age, gender, type of diabetes mellitus (DM I or II) duration of diabetes mellitus, history of hypertension, history of insulin use, height, weight, and body mass index, smoking history, glycosylated hemoglobin, creatinine levels, and cholesterol levels. Results: The mean age of subjects with no diabetic retinopathy was 56.38 years (SD, 10.16), whereas that of patients with proliferative diabetic retinopathy was 57.43 years (SD, 9.63). Parameters that conferred a statistically significant increased risk for proliferative diabetic retinopathy in the multivariate model included gender (men were at higher risk: odds ratio [OR], 4.11; 95% confidence interval [CI], 2.56–6.58), insulin use (OR, 1.85; 95% CI, 1.13–3.03), history of hypertension (OR, 1.64; 95% CI, 1.02–2.63), and duration (>25 years vs. 10–15 years) of diabetes (OR, 22.00; 95% CI, 9.76–49.60). Conclusion: In this case–control study in a Latino population, duration of diabetes and male gender were the strongest risk factor for the development of proliferative diabetic retinopathy followed by insulin use and hypertension. Interestingly, smoking and glycosylated hemoglobin levels did not confer additional significant risk in this cohort.
Characterization of an iridescent virus isolated from Gryllus bimaculatus (Orthoptera: Gryllidae).

We have isolated an iridescent virus from commercially produced colonies of Gryllus bimaculatus in Germany, which showed apparent mortality. Transmission electron microscopy studies on adult cricket specimens revealed the paracrystalline assembly of icosahedral virus particles in the cytoplasm of hypertrophied abdominal fat body cells. The infecting agent could be cultivated in the lepidopteran cell line sf-9, where it caused cytopathogenic effects such as cell hypertrophy, cytoplasmic vacuolization, and cell death within 8 days postinfection. Infection titers of the first virus passage reached 10(7.5) TCID(50)/ml. Negatively stained virus particles (n = 100) had dimensions of 172 +/- 6 nm (apex to apex) and 148 +/- 5 nm (side to side). SDS-polyacrylamide gel electrophoresis of virus proteins showed more than 20 distinct polypeptides with a major species of approximately 50 kDa. Analysis of the restriction fragment length profiles from digestion of purified viral DNA with the endonucleases EcoRI, BamHI, and HindIII showed marked differences from the profiles of iridoviruses of lower vertebrates (genus Ranavirus), e.g., Rana esculenta Iridovirus and Frog virus 3. Restriction enzyme digests with the endonucleases MspI and HpaII indicated the lack of methylation of viral DNA. Polymerase chain reaction led to the amplification of a 420-bp gene fragment with 97% sequence homology to the major capsid protein gene of Chilo iridescent virus. These data indicate that this new isolate, which we propose to be termed Gryllus bimaculatus iridescent virus, belongs to the genus Iridovirus of the family Iridoviridae.