Miracle-dz/UniFAR-FTUs huggingface dataset:
Attending to the possibilities of action

Actions taking place in the environment are critical for our survival. We review evidence on attention to action, drawing on sets of converging evidence from neuropsychological patients through to studies of the time course and neural locus of action-based cueing of attention in normal observers. We show that the presence of action relations between stimuli helps reduce visual extinction in patients with limited attention to the contralesional side of space, while the first saccades made by normal observers and early perceptual and attentional responses measured using electroencephalography/event-related potentials are modulated by preparation of action and by seeing objects being grasped correctly or incorrectly for action. With both normal observers and patients, there is evidence for two components to these effects based on both visual perceptual and motor-based responses. While the perceptual responses reflect factors such as the visual familiarity of the action-related information, the motor response component is determined by factors such as the alignment of the objects with the observer's effectors and not by the visual familiarity of the stimuli. In addition to this, we suggest that action relations between stimuli can be coded pre-attentively, in the absence of attention to the stimulus, and action relations cue perceptual and motor responses rapidly and automatically. At present, formal theories of visual attention are not set up to account for these action-related effects; we suggest ways that theories could be expected to enable action effects to be incorporated.
Neurocognitive networks in higher-level visual perception

The ability to accurately perceive and respond to our visual environment is critical for optimising primate behaviour. A number of related cognitive functions, such as visual learning and longer-term memory, also depend upon an accurate percept of objects and their location within the visual environment. Understanding how the healthy brain supports higher-order visual perception is, therefore, a key goal for cognitive neuroscientist. A substantial body of research involving both humans and animals highlights a role for regions within the extrastriate cortex in visual perception, with many of these regions apparently exhibiting a high degree of functional specialisation for the processing of particular categories of complex stimuli (e.g. faces versus scenes). More recently, studies have found that patients with damage to structures within the medial temporal lobe, such as the hippocampus and perirhinal cortex, can also present with impairments in higher-level perception. More specifically, damage to perirhinal cortex has been linked to impairments in perception for complex objects and faces, whereas hippocampal damage has been linked to impairments in scene perception. Multiple regions distributed across the extrastriate cortex and medial temporal lobe may make individual category-sensitive contributions to visual perception, but it remains unclear how these regions interact with one another, and to what extent their ability to interact underpins successful visual perception. These issues are addressed here via a series of novel experiments involving a combination of behavioural paradigms and magnetic resonance imaging techniques in healthy human participants. These experiments aim to: a) investigate the functional and structural connections that support the category-sensitive contributions of the perirhinal cortex and hippocampus to higher-level visual perception; b) demonstrate that inter-individual variation in the structural properties of white matter pathways providing inputs/outputs to the perirhinal cortex or hippocampus is an important factor underpinning the contributions of these regions to successful higher-level perceptions.
Using Authentic Videos to Improve EFL Students’ Listening Comprehension

The purpose of this study was to investigate the effect of the use of video resources on improving listening comprehension. 86 students enrolled in a summer session at a Korean university participated in the study. They were assigned to one of three groups based on the results of their TOEIC test scores: 29 students were assigned to the low group, 29 students to the intermediate group, and 28 students to the advanced group. Each group studied the same lessons using authentic video materials. They were taught for 10 sessions over three weeks. The pre- and post-test design helped to determine whether authentic videos were effective in improving listening skills for all proficiency levels. In addition, a questionnaire investigated students’ perceptions toward using video resources. Paired sample t-tests, ANOVAs, and an ANCOVA were utilized to identify significant differences. It was concluded that in the intermediate and advanced proficiency groups, the students’ listening skills increased significantly after learning with videos. In addition, listening improvements among the intermediate and advanced students were much greater than those of the low proficiency group. As for students’ perceptions toward using video resources for improving their English listening skills, they responded positively. Based on these findings, pedagogical implications are suggested, and future studies will be discussed.
Omalizumab therapy for chronic spontaneous urticaria: the Israeli experience.

BACKGROUND Chronic spontaneous urticaria (CSU) is a common, debilitating disease that is frequently resistant to standard therapy. Omalizumab, anti-immunoglobulin-E humanized monclonal antibody, was recently shown to be effective in treating resistant CSU. OBJECTIVES To investigated the treatment of CSU with omalizumab in Israel. METHODS We conducted a multicenter retrospective analysis of patients with refractory CSU treated with omalizuamb in Israel during 2012-2013. Complete improvement was defined as resolution of symptoms with no need for other medications, or satisfactory when patients' condition improved but required regular or intermittent doses of antihistamines. RESULTS Forty-three patients received omalizumab off-label for refractory CSU. Their mean age was 45 +/- 12 years and CSU duration was 4.3 +/- 4 years. In this cohort, 98% were unsuccessfully treated with high dose H(1)-antihistamines, 88% with systemic glucocorticoids and 30% with cyclosporine and/ or other immune-modulators. Fourteen patients received only one injection of omalizumab, while the other 29 received on average of 4.3 +/- 3.2 injections; 30 patients received 150 mg/ month and 13 received 300 mg/month. Following omalizumab therapy, disease remitted within weeks in 86% of patients, of whom half achieved complete remission. The latter was associated with usage of high dose omalizumab, 300 mg/month vs. 150 mg/month (P = 0.02) and repeated therapy (i.e., multiple injections vs. a single injection) (P = 0.0005). CONCLUSIONS Omalizumab is an effective and safe treatment for refractory CSU with rapid onset of action for inducing and maintaining remission. Treating CSU patients mandates an individual approach, because while low dose omalizumab will suffice for some patients others might need higher doses and prolonged therapy.
Drivers of exceptionally cold North Atlantic Ocean temperatures and their link to the 2015 European heat wave

The North Atlantic and Europe experienced two extreme climate events in 2015: exceptionally cold ocean surface temperatures and a summer heat wave ranked in the top ten over the past 65 years. Here, we show that the cold ocean temperatures were the most extreme in the modern record over much of the mid-high latitude North-East Atlantic. Further, by considering surface heat loss, ocean heat content and wind driven upwelling we explain for the first time the genesis of this cold ocean anomaly. We find that it is primarily due to extreme ocean heat loss driven by atmospheric circulation changes in the preceding two winters combined with the re-emergence of cold ocean water masses. Furthermore, we reveal that a similar cold Atlantic anomaly was also present prior to the most extreme European heat waves since the 1980s indicating that it is a common factor in the development of these events. For the specific case of 2015, we show that the ocean anomaly is linked to a stationary position of the Jet Stream that favours the development of high surface temperatures over Central Europe during the heat wave. Our study calls for an urgent assessment of the impact of ocean drivers on major European summer temperature extremes in order to provide better advance warning measures of these high societal impact events.
Language Revitalisation Models in Minority Language Contexts: Tensions between Ideologies of Authenticity and Anonymity

This article looks at the historicisation of the native speaker and ideologies of authenticity and anonymity in Europe's language revitalisation movements. It focuses specifically on the case of Irish in the Republic of Ireland and examines how the native speaker ideology and the opposing ideological constructs of authenticity and anonymity filter down to the belief systems and are discursively produced by social actors on the ground. For this I draw on data from ongoing fieldwork in the Republic of Ireland, drawing on interviews with a group of Irish language enthusiasts located outside the officially designated Irish-speaking Gaeltacht.
Transient kinetics of formation and reaction of the uridylyl-enzyme form of galactose-1-P uridylyltransferase and its Q168R-variant: insight into the molecular basis of galactosemia.

Galactose-1-phosphate uridylyltransferase catalyzes the reaction of UDP-glucose with galactose 1-phosphate (Gal-1-P) to form UDP-galactose and glucose 1-phosphate (Glc-1-P) through a double displacement mechanism, with the intermediate formation of a covalent uridylyl-enzyme (UMP enzyme). Gln 168 in E. coli uridylyltransferase engages in hydrogen bonding with the phosphoryl oxygens of the UMP moiety, which is bonded to His 166 in the intermediate [Wedekind, J. E. , Frey, P. A. , and Rayment, I. (1996) Biochemistry 35, 11560-11569]. In humans, the point variant Q188R accounts for 60% of galactosemia cases. The corresponding E. coli variant Q168R has been overexpressed and purified. In preparation for kinetic correlation of Q168R and wild-type uridylyltransferases, we tested the kinetic competence of the wild-type UMP-enzyme. At 4 degreesC, the first-order rate constant for uridylylation by UDP-glucose is 281 +/- 18 s-1, and for deuridylylation it is 226 +/- 10 s-1 with Glc-1-P and 166 +/- 10 s-1 with Gal-1-P. Inasmuch as the overall turnover number at 4 degreesC is 62 s-1, the covalent intermediate is kinetically competent. The variant Q168R is uridylylated by UDP-glucose to the extent of about 65% of the potential active sites. Uridylylation reactions of Q168R with UDP-glucose proceed with maximum first-order rate constants of 2.2 x 10(-)4 s-1 and 4.2 x 10(-)4 s-1 at 4 and 27 degreesC, respectively. In experiments with uridylyl-Q168R and glucose-1-P, the mutant enzyme undergoes deuridylylation with maximum first-order rate constants of 4.8 x 10(-)4 s-1 and 1.68 x 10(-)3 s-1 at 4 and 27 degreesC, respectively. The value of Km for uridylylation of Q168R is slightly higher than for the wild-type enzyme, and for deuridylylation it is similar to the wild-type value. The wild-type enzyme undergoes uridylylation and deuridylyation about 10(6) times faster than Q168R. The wild-type activity in the overall reaction is 1.8 x 10(6) times that of Q168R. The wild-type enzyme contains 1.9 mol of Zn+Fe per mole of subunits, whereas the Q168R-variant contains 1.36 mol of Zn+Fe per mole of subunits. The mutation stabilizes the uridylyl-enzyme by 1.2 kcal mol-1 in comparison to the wild-type enzyme. These results show that the low activity of Q168R is not due to overstabilization of the intermediate or to the absence of structural metal ions. Instead, the main defect is very slow uridylylation and deuridylation.
Relating Communicating Processes with Different Interfaces

We present here an implementation relation intended to formalise the notion that a system built of communicating processes is an acceptable implementation of another base, or target, system in the event that the two systems have different interfaces. Such a treatment has clear applicability in the software development process, where (the interface of) an implementation component may be expressed at a different level of abstraction to (the interface of) the relevant specification component.Technically, processes are formalised using Hoare's CSP language, with its standard failures-divergences model. The implementation relation is formulated in terms of failures and divergences of the implementation and target processes. Interface difference is modelled by endowing the implementation relation with parameters called extraction patterns. These are intended to interpret implementation behaviour as target behaviour, and suitably constrain the former in connection to well-formedness and deadlock properties.We extend the results of our previous work and replace implementation relations previously presented by a single, improved scheme. We also remove all the restrictions previously placed upon target processes. Two basic kinds of results are obtained: realisability and compositionality. The latter means that a target composed of several connected systems may be implemented by connecting their respective implementations. The former means that, if target and implementation in fact have the same interface, then the implementation relation they should satisfy collapses into standard implementation pre-order.We also show how to represent processes and extraction patterns in a manner amenable to computer implementation, and detail a graph-theoretic restatement of the conditions defining the implementation relation, from which algorithms for their automatic verification are easily derived.
Metabolic Aromatization of N-Alkyl-1,2,3,4-Tetrahydroquinoline Substructures to Quinolinium by Human Liver Microsomes and Horseradish Peroxidase

Metabolic aromatization of xenobiotics is an unusual reaction with some documented examples. For instance, the oxidation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine to the neurotoxic pyridinium ion metabolite 1-methyl-4-phenylpyridinium by monoamine oxidase (MAO) B in the brain has been of interest to a number of investigators. It has also been reported that although the aromatization of N-methyl-tetrahydroisoquinoline occurs with MAO B, the metabolism does not proceed for its isomer, N-methyl-tetrahydroquinoline, by the same enzyme. The aromatization of an N-alkyl-tetrahydroquinoline substructure was identified during in vitro metabolite profiling of compound A, which was designed as a potent renin inhibitor for the treatment of hypertension. The N-alkylquinolinium metabolite of compound A was identified by liquid chromatography-tandem mass spectrometry of human liver microsomal incubates and proton NMR of the isolated metabolite. Further in vitro metabolism studies with a commercially available chemical (compound B), containing the same substructure, also generated an N-alkylquinolinium metabolite. In vitro cytochrome P450 (P450) reaction phenotyping of compound A revealed that the metabolism was catalyzed exclusively by CYP3A4. Although compound B was a substrate for several P450 isoforms, its quinolinium metabolite was also generated predominantly by CYP3A4. Neither compound A nor compound B was a substrate of MAOs. The quinolinium metabolites were readily produced by horseradish peroxidase, suggesting that aromatization of the N-alkyltetrahydroquinoline could occur via a mechanism involving single electron transfer from nitrogen. Although dihydro intermediates from the tetrahydroquinoline substrates were not observed in the formation of quinolinium metabolites, cyanide trapping results indicated the occurrence of iminium intermediates.
Detection of artifacts on photoplethysmography signals using random distortion testing

In this work, we describe a novel method based on waveform morphology for detecting artifacts in photoplethysmography (PPG) signals and, thus, improve reliability of PPG. By considering inter-individual and measure condition variability, specific parameters are estimated for each record. We introduce a novel metric for comparing pulses, which is the derivative of the correlation coefficient. Then, we propose a detection method based on Random Distortion Testing (RDT), to perform adaptive threasholding for each record. The results show that the proposed method provides pertinent detection of pulses with artifacts. Tested on 104 PPG records, the mean of sensitivity, specificity and accuracy were 84 ± 16%, 83 ± 12% and 83 ± 8%, respectively.
An Economical Business-Cycle Model

This article develops a new model of business cycles. The model is economical in that it is solved with an aggregate demand–aggregate supply diagram, and the effects of shocks and policies are obtained by comparative statics. The model builds on two unconventional assumptions. First, producers and consumers meet through a matching function. Thus, the model features unemployment, which fluctuates in response to aggregate demand and supply shocks. Secondly, wealth enters the utility function, so the model allows for permanent zero-lower-bound episodes. In the model, the optimal monetary policy is to set the interest rate at the level that eliminates the unemployment gap. This optimal interest rate is computed from the prevailing unemployment gap and monetary multiplier (the effect of the nominal interest rate on the unemployment rate). If the unemployment gap is exceedingly large, monetary policy cannot eliminate it before reaching the zero lower bound, but a wealth tax can.
Perception in statistical graphics

xii CHAPTER 1. LITERATURE REVIEW 1 1.1 The Human Visual System . 1 1.1.1 Hardware . 2 1.1.2 Software . 5 1.1.3 Bugs and Peculiarities of the Visual System . 12 1.1. 4 Cognitive Load . 20 1.2 Statistical Graphics . 22 1.2. 1 Preattentive Perception of Statistical Graphics . 23 1.2. 2 Conscious Perception of Statistical Graphics . 24 1.3 Testing Statistical Graphics . 32 1.3. 1 Basic Psychophysics Methodology . 32 1.3. 2 Testing Images using Psychological Paradigms . 35 1.3. 3 Testing Statistical Graphics . 39
Longitudinal effects of Botox injections on voice-related quality of life (V-RQOL) for patients with adductory spasmodic dysphonia: part II.

OBJECTIVE To investigate the longitudinal effects of botulinum toxin type A (Botox) injections on voice-related quality of life (V-RQOL) for patients with adductory spasmodic dysphonia. DESIGN Prospective study. SETTING Academic tertiary care referral center. PARTICIPANTS Forty-two patients who presented to our institution with dysphonia and were diagnosed as having adductory spasmodic dysphonia during a 38-month period. INTERVENTION Patients received Botox injections into both thyroarytenoid muscles via the cricothyroid membrane. The typical starting dose was 1.0 U per vocal fold. If necessary, the dosage was adjusted in subsequent injections to reduce adverse effects or to enhance duration of benefit. MAIN OUTCOME MEASURES Patients filled out questionnaires, including the V-RQOL Measure and a self-assessed overall voice rating, before each injection. Postinjection questionnaires were completed 6 to 8 weeks after each treatment. Mean pretreatment and posttreatment scores were calculated for each treatment. RESULTS The number of treatments per patient ranged from 1 to 7. Statistically significant improvements in mean total and domain V-RQOL scores were calculated for every injection (P<.01) (no postinjection questionnaires were available for the seventh injections). The magnitude of the effect remained constant for later injections. Eighty-two percent of the population recorded at least 1 category of improvement in overall self-assessed voice rating with each injection. CONCLUSIONS Botox has a significant beneficial effect on V-RQOL for at least 6 injection cycles. This study demonstrates the efficacy of Botox for treating patients with adductory spasmodic dysphonia and further illustrates the usefulness and validity of the V-RQOL Measure in evaluating patients with dysphonia.
Application of the Objective Structure Clinical Evaluation in Evaluating Clinical Competence for a BSN Program

Given the complex clinical situations and the dynamic nature of nursing, the greatest challenge for nursing educators is performing objective evaluation of students’ clinical competence. The Objective Structured Clinical Evaluation (OSCE) is designed to address this challenge and it has been widely used in nursing education. However, its implementation in nursing education in Taiwan has been limited. Accordingly, a quasi-experimental design was utilized to examine students’ clinical performance and stress levels using a 12-station OSCE assessment. Further, we investigated the inter-rater reliability and internal consistency of the OSCE. After controlling for scores of clinical performance, overall differences in pre- and post-practicum stress in the OSCE group were significantly higher than in the control group (F (1, 89) = 4.89, p = 0.03). There was no group effect on practicum performance after controlling for grade point average (F (1, 89) = 2.69, p = 0.14). Cronbach’s alpha for 12 OSCE stations ranged from 0.22 to 0.80 and inter-rater reliability for all 12 stations showed Pearson’s r ranging between 0.76 and 1.00. Cohen’s kappa ranged from 0.70 to 1.00 (p
RGS2 blocks slow muscarinic inhibition of N‐type Ca2+ channels reconstituted in a human cell line

1 Native N‐type Ca2+ channels undergo sustained inhibition through a slowly activating pathway linked to M1 muscarinic acetylcholine receptors and Gαq/11 proteins. Little is known concerning the regulation of this slow inhibitory pathway. We have reconstituted slow muscarinic inhibition of N‐type channels in HEK293 cells (a human embryonic kidney cell line) by coexpressing cloned α1B (CaV2.2) Ca2+ channel subunits and M1 receptors. Expressed Ca2+ currents were recorded using standard whole‐cell, ruptured‐patch techniques. 2 Rapid application of carbachol produced two kinetically distinct components of Ca2+ channel inhibition. The fast component of inhibition had a time constant of < 1 s, whereas the slow component had a time constant of 5‐40 s. Neither component of inhibition was reduced by pertussis toxin (PTX) or staurosporine. 3 The fast component of inhibition was selectively blocked by the Gβγ‐binding region of β‐adrenergic receptor kinase 1, suggesting that fast inhibition is mediated by Gβγ released from Gαq/11. 4 The slow component of inhibition was selectively blocked by regulator of G protein signalling 2 (RGS2), which preferentially interacts with Gαq/11 proteins. RGS2 also attenuated channel inhibition produced by intracellular dialysis with non‐hydrolysable GTPγS. Together these results suggest that RGS2 selectively blocked slow inhibition by functioning as an effector antagonist, rather than as a GTPase‐accelerating protein (GAP). 5 These experiments demonstrate that slow muscarinic inhibition of N‐type Ca2+ channels can be reconstituted in non‐neuronal cells, and that RGS2 can selectively block slow muscarinic inhibition while leaving fast muscarinic inhibition intact. These results identify RGS2 as a potential physiological regulator of the slow muscarinic pathway.