Miracle-dz/UniFAR-FTUs huggingface dataset:
Unveiling Zeus: automated classification of malware samples

Malware family classification is an age old problem that many Anti-Virus (AV) companies have tackled. There are two common techniques used for classification, signature based and behavior based. Signature based classification uses a common sequence of bytes that appears in the binary code to identify and detect a family of malware. Behavior based classification uses artifacts created by malware during execution for identification. In this paper we report on a unique dataset we obtained from our operations and classified using several machine learning techniques using the behavior-based approach. Our main class of malware we are interested in classifying is the popular Zeus malware. For its classification we identify 65 features that are unique and robust for identifying malware families. We show that artifacts like file system, registry, and network features can be used to identify distinct malware families with high accuracy - in some cases as high as 95 percent.
Energy implications of photonic networks with speculative transmission

Speculative transmission has been proposed to overcome the high latency of setting up end-to-end paths through photonic networks for computer systems. However, speculative transmission has implications for the energy efficiency of the network, in particular, control circuits are more complex and power hungry and failed speculative transmissions must be repeated. Moreover, in future chip multiprocessors (CMPs) with integrated photonic network end points, a large proportion of the additional energy will be dissipated on the CMP. This paper compares the energy characteristics of scheduled and speculative chip-to-chip networks for shared memory computer systems on the scale of a rack. For this comparison, we use a novel speculative control plane which reduces energy consumption by eliminating duplicate packets from the allocation process. In addition, we consider photonic power gating to reduce processor chip energy dissipation and the energy impact of the choice between semiconductor optical amplifier and ring resonator switching technologies. We model photonic network elements using values from the published literature as well as determine the power consumption of the allocator and network adapter circuits, implemented in a commercial low leakage 45 nm CMOS process. The power dissipated on the CMP using speculative networks is shown to be roughly double that of scheduled networks at saturation load and an order of magnitude higher at low loads.
Enhancing emotional experiences to dance through music: the role of valence and arousal in the cross-modal bias

It is well established that emotional responses to stimuli presented to one perceptive modality (e.g., visual) are modulated by the concurrent presentation of affective information to another modality (e.g., auditory)—an effect known as the cross-modal bias. However, the affective mechanisms mediating this effect are still not fully understood. It remains unclear what role different dimensions of stimulus valence and arousal play in mediating the effect, and to what extent cross-modal influences impact not only our perception and conscious affective experiences, but also our psychophysiological emotional response. We addressed these issues by measuring participants’ subjective emotion ratings and their Galvanic Skin Responses (GSR) in a cross-modal affect perception paradigm employing videos of ballet dance movements and instrumental classical music as the stimuli. We chose these stimuli to explore the cross-modal bias in a context of stimuli (ballet dance movements) that most participants would have relatively little prior experience with. Results showed (i) that the cross-modal bias was more pronounced for sad than for happy movements, whereas it was equivalent when contrasting high vs. low arousal movements; and (ii) that movement valence did not modulate participants’ GSR, while movement arousal did, such that GSR was potentiated in the case of low arousal movements with sad music and when high arousal movements were paired with happy music. Results are discussed in the context of the affective dimension of neuroentrainment and with regards to implications for the art community.
Mental Rotation: A Key to Mitigation of Motion Sickness in the Virtual Environment?

Some of our recent observations suggest that mental rotation may be important for reduction of motion sickness in microgravity as well as in the microgravity simulator. Therefore, we suggest that development of the ability to perform mental rotation may be important for adaptation to many virtual environments. Training virtual environment operators to perform mental rotation may enhance operator performance both by increasing their ability to "locomote in" and manipulate that environment and by reducing motion sickness associated with transitions between virtual and normal environments.
Comparative Cytomorphologic Aspects of the Male Germ Cells, Especially of the “Gonia” *

During early development of the human testis the male germ cell first appears as primordial germ cell or gonocyte and enters the prospermatogonial stage after the twelfth week of gestation. Prospermatogonia lack glycogen particles and are connected by intercellular bridges. During the same period in the ovary the female germ cell undergoes its oogonial stage.
Fused Multiply-Add Microarchitecture Comprising Separate Early-Normalizing Multiply and Add Pipelines

We present an IEEE 754-2008 and ARM compliant floating-point micro architecture that preserves the higher performance of separate multiply and add units while decreasing the effective latency of fused multiply-adds (FMAs). The multiplier supports subnormals in a novel and faster manner, shifting the partial products so that injection rounding can be used. The early-normalizing adder retains the low latency of a split path near/far adder, but does so in a unified path with less area. The adder also allows rounding on effective subtractions involving one input that is twice the normal width, a necessary feature for handling FMAs. The resulting floating-point unit has about twice the (IPC) performance of the best previous ARM design, and can be clocked at a higher speed despite the wider paths required by FMAs.
Computed tomography morphometric analysis for C-1 lateral mass screw placement in children. Clinical article.

OBJECT The use of C-1 lateral mass screws provides an alternative to C1-2 transarticular screws in the pediatric population. However, the confined space of the local anatomy and unfamiliarity with the technique may make the placement of a C-1 lateral mass screw more challenging, especially in the juvenile or growing spine. METHODS A CT morphometric analysis was performed in 76 pediatric atlases imaged at Texas Children's Hospital from October 1, 2007 until April 30, 2008. Critical measurements were determined for potential screw entry points, trajectories, and lengths, with the goal of replicating the operative technique described by Harms and Melcher for adult patients. RESULTS The mean height and width for screw entry on the posterior surface of the lateral mass were 2.6 and 8.5 mm, respectively. The mean medially angled screw trajectory from an idealized entry point on the lateral mass was 16 degrees (range 4 to 27 degrees ). The mean maximal screw depth from this same ideal entry point was 20.3 mm. The overhang of the posterior arch averaged 6.3 mm (range 2.1-12.4 mm). The measurement between the left- and right-side lateral masses was significantly different for the maximum medially angled screw trajectory (p = 0.003) and the maximum inferiorly directed angle (p = 0.045). Those measurements in children < 8 years of age were statistically significant for the entry point height (p = 0.038) and maximum laterally angled screw trajectory (p = 0.025) compared with older children. The differences between boys and girls were statistically significant for the minimum screw length (p = 0.04) and the anterior lateral mass height (p < 0.001). CONCLUSIONS A significant variation in the morphological features of C-1 exists, especially between the left and right sides and in younger children. The differences between boys and girls are clinically insignificant. The critical measurement of whether the C-1 lateral mass in a child could accommodate a 3.5-mm-diameter screw is the width of the lateral mass and its proximity to the vertebral artery. Only 1 of 152 lateral masses studied would not have been able to accommodate a lateral mass screw. This study reemphasizes the importance of a preoperative CT scan of the upper cervical spine to assure safe and effective placement of the instrumentation at this level.
SoxF Transcription Factors Are Positive Feedback Regulators of VEGF Signaling.

RATIONALE Vascular endothelial growth factor (VEGF) signaling is a key pathway for angiogenesis and requires highly coordinated regulation. Although the Notch pathway-mediated suppression of excessive VEGF activity via negative feedback is well known, the positive feedback control for augmenting VEGF signaling remains poorly understood. Transcription factor Sox17 is indispensable for angiogenesis, but its association with VEGF signaling is largely unknown. The contribution of other Sox members to angiogenesis also remains to be determined. OBJECTIVE To reveal the genetic interaction of Sox7, another Sox member, with Sox17 in developmental angiogenesis and their functional relationship with VEGF signaling. METHODS AND RESULTS Sox7 is expressed specifically in endothelial cells and its global and endothelial-specific deletion resulted in embryonic lethality with severely impaired angiogenesis in mice, substantially overlapping with Sox17 in both expression and function. Interestingly, compound heterozygosity for Sox7 and Sox17 phenocopied vascular defects of Sox7 or Sox17 homozygous knockout, indicating that the genetic cooperation of Sox7 and Sox17 is sensitive to their combined gene dosage. VEGF signaling upregulated both Sox7 and Sox17 expression in angiogenesis via mTOR pathway. Furthermore, Sox7 and Sox17 promoted VEGFR2 (VEGF receptor 2) expression in angiogenic vessels, suggesting a positive feedback loop between VEGF signaling and SoxF. CONCLUSIONS Our findings demonstrate that SoxF transcription factors are indispensable players in developmental angiogenesis by acting as positive feedback regulators of VEGF signaling.
Is dementia incidence declining?

Objective: To investigate whether dementia incidence has changed over the last 2 decades. Methods: We compared dementia incidence in 2 independent subcohorts of persons aged 60–90 years from the Rotterdam Study, a population-based cohort study. The first subcohort started in 1990 (n = 5,727), the second in 2000 (n = 1,769). Participants were dementia-free at baseline and followed for at maximum 5 years. We calculated age-adjusted dementia incidence rates for the 2 subcohorts in total, in 10-year age strata, and for men and women separately. We also compared mortality rates, differences in prevalence of vascular risk factors, and medication use. Finally, we compared brain volumes and the extent of cerebral small vessel disease in participants who underwent brain imaging 5 years after the baseline examinations. Results: In the 1990 subcohort (25,696 person-years), 286 persons developed dementia, and in the 2000 subcohort (8,384 person-years), 49 persons. Age-adjusted dementia incidence rates were consistently, yet nonsignificantly, lower in the 2000 subcohort in all strata, reaching borderline significance in the overall analysis (incidence rate ratio 0.75, 95% confidence interval [CI] 0.56–1.02). Mortality rates were also lower in the 2000 subcohort (rate ratio 0.63, 95% CI 0.52–0.77). The prevalence of hypertension and obesity significantly increased between 1990 and 2000. This was paralleled by a strong increase in use of antithrombotics and lipid-lowering drugs. Participants in 2005–2006 had larger total brain volumes (p < 0.001) and less cerebral small vessel disease (although nonsignificant in men) than participants in 1995–1996. Conclusions: Although the differences in dementia incidence were nonsignificant, our study suggests that dementia incidence has decreased between 1990 and 2005.
Fair energy-efficient sensing task allocation in participatory sensing with smartphones

With the proliferation of smartphones, participatory sensing using smartphones provides unprecedented opportunities for collecting enormous sensing data. There are two crucial requirements in participatory sensing, fair task allocation and energy efficiency, which are particularly challenging given high combinatorial complexity, tradeoff between energy efficiency and fairness, and dynamic and unpredictable task arrivals. In this paper, we present a novel fair energy-efficient allocation framework whose objective is characterized by min-max aggregate sensing time. We rigorously prove that optimizing the min-max aggregate sensing time is NP hard even when the tasks are assumed as a priori. We consider two allocation models: offline allocation and online allocation. For the offline allocation model, we design an efficient approximation algorithm with the approximation ratio of 2 - 1/m, where m is the number of member smartphones in the system. For the online allocation model, we propose a greedy online algorithm which achieves a competitive ratio of at most m. The results demonstrate that the approximation algorithm reduces over 81% total sensing time, the greedy online algorithm reduces more than 73% total sensing time, and both algorithms achieve over 3x better min-max fairness.
DISSIPATIVE PARTICLE DYNAMICS IN SOFT MATTER AND POLYMERIC APPLICATIONS — A

Computer simulations and in particular mesoscopic simulation techniques such as the dissipative particle dynamics (DPD) technique, enable researchers to study the complexities of soft material and polymeric systems by performing in silico experimentations alongside in vivo experiments. In addition, these mesoscopic simulations allow scientists and engineers to characterize and optimize the actual experiments in a more efficient manner. The DPD is one the most reliable mesoscopic simulation techniques for phenomenological investigation of soft matter and polymeric systems. In this review, which is complimentary to an earlier review also by the present authors on DPD methodology and complex fluid application (Moeendarbary et al., 2009), we categorize and review the notable published works, and document efforts that applied the DPD simulation technique to various important soft matter and polymeric applications, over the last decade.
Motor Assessment of the Developing Infant

Theories of Motor Development. Motor Assessment of the Developing Infant. Alberta Infant Motor Scale: Construction of a Motor Assessment Tool for the Developing Infant. Administration Guidelines. Prone Subscale. Supine Subscale. Sit Subscale. Stand Subscale. Clinical Uses of the Alberta Infant Motor Scale. Psychometric Properties of the Aims. Norm-Referencing of the Alberta Infant Motor Scale.
Ad hoc-VCG: a truthful and cost-efficient routing protocol for mobile ad hoc networks with selfish agents

We introduce a game-theoretic setting for routing in a mobile ad hoc network that consists of greedy, selfish agents who accept payments for forwarding data for other agents if the payments cover their individual costs incurred by forwarding data. In this setting, we propose Ad hoc-VCG, a reactive routing protocol that achieves the design objectives of truthfulness (i.e., it is in the agents' best interest to reveal their true costs for forwarding data) and cost-efficiency (i.e., it guarantees that routing is done along the most cost-efficient path) in a game-theoretic sense by paying to the intermediate nodes a premium over their actual costs for forwarding data packets. We show that the total overpayment (i.e., the sum of all premiums paid) is relatively small by giving a theoretical upper bound and by providing experimental evidence. Our routing protocol implements a variation of the well-known mechanism by Vickrey, Clarke, and Groves in a mobile network setting. Finally, we analyze a very natural routing protocol that is an adaptation of the Packet Purse Model [8] with auctions in our setting and show that, unfortunately, it does not achieve cost-efficiency or truthfulness.
Visual cells in the temporal cortex sensitive to face view and gaze direction

The direction of eye gaze and orientation of the face towards or away from another are important social signals for man and for macaque monkey. We have studied the effects of these signals in a region of the macaque temporal cortex where cells have been found to be responsive to the sight of faces. Of cells selectively responsive to the sight of the face or head but not to other objects (182 cells) 63% were sensitive to the orientation of the head. Different views of the head (full face, profile, back or top of the head, face rotated by 45° up to the ceiling or down to the floor) maximally activated different classes of cell. All classes of cell, however, remained active as the preferred view was rotated isomorphically or was changed in size or distance. Isomorphic rotation by 90–180° increased cell response latencies by 10–60 ms. Sensitivity to gaze direction was found for 64% of the cells tested that were tuned to head orientation. Eighteen cells most responsive to the full face preferred eye contact, while 18 cells tuned to the profile face preferred averted gaze. Sensitivity to gaze was thus compatible with, but could be independent of, sensitivity to head orientation. Results suggest that the recognition of one type of object may proceed via the independent high level analysis of several restricted views of the object (viewer-centred descriptions).
Endothelial dysfunction in the regulation of cirrhosis and portal hypertension

Portal hypertension is caused by an increased intrahepatic resistance, a major consequence of cirrhosis. Endothelial dysfunction in liver sinusoidal endothelial cells (LSECs) decreases the production of vasodilators, such as nitric oxide, and favours vasoconstriction. This contributes to an increased vascular resistance in the intrahepatic/sinusoidal microcirculation and develops portal hypertension. Portal hypertension, in turn, causes endothelial dysfunction in the extrahepatic, i.e. splanchnic and systemic, circulation. Unlike dysfunction in LSECs, endothelial dysfunction in the splanchnic and systemic circulation causes overproduction of vasodilator molecules, leading to arterial vasodilation. In addition, portal hypertension leads to the formation of portosystemic collateral vessels. Both arterial vasodilation and portosystemic collateral vessel formation exacerbate portal hypertension by increasing the blood flow through the portal vein. Pathological consequences, such as oesophageal varices and ascites, result. While the sequence of pathological vascular events in cirrhosis and portal hypertension has been elucidated, the underlying cellular and molecular mechanisms causing endothelial dysfunctions are not yet fully understood. This review article summarizes the current cellular and molecular studies on endothelial dysfunctions found during the development of cirrhosis and portal hypertension with a focus on the intra‐ and extrahepatic circulations. The article ends by discussing the future directions of the study for endothelial dysfunction.
Modularity and the units of evolution

SummaryWhile many developmental processes (e. g., gene networks or signaling pathways) are astonishingly conserved during evolution, they may be employed differently in different metazoan taxa or may be used multiply in different contexts of development. This suggests that these processes belong to building blocks or modules, viz., highly integrated parts of the organism, which develop and/or function relatively independent from other parts. Such modules may be relatively easy to dissociate from other modules and, therefore, could also serve as units of evolution. However, in order to further explore the implications of modularity for evolution, the vague notion of “modularity” as well as its relation to concepts like “unit of evolution” need to be more precisely specified. Here, a module is characterized as a certain type of dynamic pattern of couplings among the constituents of a process. It may or may not form a spatially contiguous unit. A unit of selection is defined as a unit of those constituents of a reproducing process/system, which exists in different variants and acts as a non-decomposable unit of fitness and variant reproduction during a particular selection process. The more general notion of a unit of evolution is characterized as a nondecomposable unit of constituents with reciprocal fitness dependence, be it due to fitness epistasis or due to the lack of independent variability. Because such fitness dependence may only be observed for some combinations of variants, several constituents may act as a unit of evolution only with a certain probability (coevolution probability). It is argued, that under certain conditions modules are likely to act as units of evolution with high coevolution probabilities, because there is likely to be a close tie between the pattern of couplings of the constituents of a reproducing system and their interdependent fitness contributions. Moreover and contrary to the traditional dichotomy of genes versus organisms as units of selection, modules tend to be more important in delimiting actual units of selection than either organisms or genes, because they are less easily disrupted by recombination than organisms, while having less contextsensitive fitness values than genes. Finally, it is suggested that the evolution of modularity is self-reinforcing, because the flexibility of intermodular connections facilitates the recombination among modules and their multiple employment in new contexts.
A Novel Brushless Doubly Fed Generator for Wind Power Generation

This paper presents a novel brushless doubly fed generator for wind power generation. In contrast to conventional brushless doubly fed machine, the novel machine has a simple winding structure together with two stators and rotating modulation steels in the airgap. With the machine being intrinsically designed for gearless low speed operation, it could be an attractive direct drive system for small wind power generation. A 0.8 kW and 60 rpm prototype is analyzed and its performance is validated using finite element method.