Miracle-dz/UniFAR-FTUs huggingface dataset:
Fully Integrated Advanced Bulk FinFETs Architecture Featuring Partially-Insulating Technique for DRAM Cell Application of 40nm Generation and Beyond

For the first time, we have successfully fabricated fully integrated advanced bulk FinFETs featuring partially insulating oxide layers under source/drain (S/D), named partially-insulated- FinFETs (PI-FinFETs), to control subchannel on the bottom part of the gate in bulk FinFETs and suppress punchthrough and junction leakage currents. We observed that the junction leakage is improved about 50%, drain-induced barrier lowering (DIBL) about 25%, and lifetime of hot carrier effect (HCE) about 1 order in comparison with normal bulk FinFETs. Furthermore, we propose a novel PI-FinFET structure with pad-polysilicon side contact (PSC) in bulk-Si to reduce gate induced drain leakage (GIDL) and increase Ion with improved SCE immunity. The simulation of novel structure shows that Ion, DIBL and GIDL is improved dramatically with the same login comparison with bulk FinFETs. This advanced structure is suitable for the miniaturization of GIDL of bulk FinFETs with improved Ion, Ioff and DIBL characteristics
Work wellness in a financial services institution : a longitudinal study

The objective of this study was to test a model of work-related well-being, comprising burnout, engagement, job demands, job resources, dispositional optimism, ill health and organisational commitment. A cross-sectional survey design was used. The following measuring instruments were administered: Maslach Burnout Inventory General Survey, Utrecht Work Engagement Scale, Health and Organisational Commitment Scales of the ASSET, Job Demands-Resources Scale, Life Orientation Test and a biographical questionnaire. The study showed the central role that low optimism plays in contributing to burnout, and high optimism plays in work engagement. High social support was linked to increased cynicism, and low social support contributed to dedication. Burnout contributed to both physical and psychological ill health. Dedication and low cynicism contributed to affective commitment, whilst engagement and low cynicism contributed to behavioural commitment. OPSOMMING Die doel van hierdie studie was om 'n model van werkwelstand bestaande uit uitbranding, begeestering, werkeise, werkhulpbronne, disposisionele optimisme, swak gesondheid en organisasieverbondenheid te toets. Daar is gebruik gemaak van 'n dwarsdeursnee-opnameontwerp. Die volgende meetinstrumente is gebruik: Maslachuitbrandingsvraelys-Algemene Opname, Utrecht-werksbegeestering-skaal, Gesondheidsen Organisasieverbondenheidskale van die ASSET, Werkeise-Hulpbronne-skaal, Lewensorienteringstoets en 'n biografiese vraelys. Die studie het gedui op die sentrale rol van lae optimisme as bydraende faktor tot uitbranding en van hoe optimisme as bydraende faktor tot werkbegeestering. 'n Hoe mate van sosiale ondersteuning is gekoppel aan verhoogde sinisme, en min sosiale ondersteuning het bygedra tot toewyding. Uitbranding het bygedra tot swak gesondheid fisiek sowel as geestelik. Toewyding en lae sinisme het bygedra tot affektiewe verbondenheid, terwyl begeestering en lae sinisme bygedra het tot gedragsverbondenheid.
Benefits of Depth in Neural Networks

For any positive integer $k$, there exist neural networks with $\Theta(k^3)$ layers, $\Theta(1)$ nodes per layer, and $\Theta(1)$ distinct parameters which can not be approximated by networks with $\mathcal{O}(k)$ layers unless they are exponentially large --- they must possess $\Omega(2^k)$ nodes. This result is proved here for a class of nodes termed "semi-algebraic gates" which includes the common choices of ReLU, maximum, indicator, and piecewise polynomial functions, therefore establishing benefits of depth against not just standard networks with ReLU gates, but also convolutional networks with ReLU and maximization gates, sum-product networks, and boosted decision trees (in this last case with a stronger separation: $\Omega(2^{k^3})$ total tree nodes are required).
Altered Mitogen‐Activated Protein Kinase Activation In Vascular Smooth Muscle Cells From Spontaneously Hypertensive Rats

1. We previously reported that activation function of mitogen‐activated protein kinases (MAPK) is enhanced in aorta strips from both prehypertensive and hypertensive spontaneously hypertensive rats (SHR) and that this enhancement of MAPK activation results from enhanced MAPK activation reactivity to angiotensin (Ang) II in SHR aorta strips.
Systematic Review: Anti–Epidermal Growth Factor Receptor Treatment Effect Modification by KRAS Mutations in Advanced Colorectal Cancer

BACKGROUND KRAS mutations have been extensively investigated as predictive biomarkers for treatment of advanced colorectal cancer with the anti-epidermal growth factor receptor (EGFR) antibodies cetuximab and panitumumab. PURPOSE To summarize whether KRAS mutation status modifies effects of anti-EGFR-based treatments for patients with advanced colorectal cancer and whether KRAS status predicts clinical outcomes among such patients. DATA SOURCES MEDLINE and 2 curated genetics databases (through 24 March 2010) were searched for observational studies. MEDLINE, the Cochrane Central Register of Controlled Trials, the Cochrane Database of Systematic Reviews, and the Database of Abstracts of Reviews of Effects (through 1 September 2010) were searched for randomized, controlled trials. No search was restricted by language. STUDY SELECTION Three reviewers screened titles and abstracts to identify published studies assessing KRAS mutations as predictors of overall and progression-free survival or treatment failure for patients who received anti-EGFR-based therapy for metastatic colorectal cancer. DATA EXTRACTION Three investigators extracted data on population and study-design characteristics, including quality items, and on outcomes of interest. Random-effects meta-analyses were done on nonoverlapping studies. DATA SYNTHESIS In 4 reanalyses of randomized trials of anti-EGFR-based therapy versus best supportive care or cytotoxic chemotherapy, no significant benefit was found for overall or progression-free survival from anti-EGFR-based treatment among KRAS-positive patients (hazard ratio [HR], 1.0). However, evidence favors anti-EGFR therapy among KRAS wild-type patients; the relative HR across KRAS-positive and wild-type patients was 1.30 (95% CI, 0.95 to 1.78) for overall survival and 2.22 (CI, 1.74 to 2.84) for progression-free survival by random-effects meta-analysis. In 13 cohorts of patients who received anti-EGFR antibodies, the summary HR for overall survival was 1.79 (CI, 1.48 to 2.17), with better survival in wild-type patients. The corresponding HR for progression-free survival was 2.11 (CI, 1.74 to 2.55 [16 cohorts]). In random-effects bivariate meta-analysis of 22 studies, the summary sensitivity of KRAS mutations for predicting lack of response was 0.49 (CI, 0.43 to 0.55), and summary specificity was 0.93 (CI, 0.87 to 0.97). LIMITATIONS Limited evidence from randomized studies exists. Patient-level data are needed to assess modifiers of the mutation-by-treatment interaction. Publication bias could be a concern. CONCLUSION KRAS mutations are consistently associated with reduced overall and progression-free survival and increased treatment failure rates among patients with advanced colorectal cancer treated with anti-EGFR antibodies. PRIMARY FUNDING SOURCE Agency for Healthcare Research and Quality.
Neuroscience and Biobehavioral Reviews a Non-reward Attractor Theory of Depression

Keywords: Orbitofrontal cortex Attractor networks Insula Non-reward Reward Anterior cingulate cortex Behavioural inhibition Reward reversal a b s t r a c t A non-reward attractor theory of depression is proposed based on the operation of the lateral orbitofrontal cortex and supracallosal cingulate cortex. The orbitofrontal cortex contains error neurons that respond to non-reward for many seconds in an attractor state that maintains a memory of the non-reward. The human lateral orbitofrontal cortex is activated by non-reward during reward reversal, and by a signal to stop a response that is now incorrect. Damage to the human orbitofrontal cortex impairs reward reversal learning. Not receiving reward can produce depression. The theory proposed is that in depression, this lateral orbitofrontal cortex non-reward system is more easily triggered, and maintains its attractor-related firing for longer. This triggers negative cognitive states, which in turn have positive feedback top-down effects on the orbitofrontal cortex non-reward system. Treatments for depression, including ketamine, may act in part by quashing this attractor. The mania of bipolar disorder is hypothesized to be associated with oversensitivity and overactivity in the reciprocally related reward system in the medial orbitofrontal cortex and pregenual cingulate cortex.
Physiological Changes in the Pattern of Placental Gene Expression Early in the First Trimester

Objective: To assess the physiological changes in the placental expression pattern of a panel of genes related to angiogenesis and oxidative stress during the early part of the first trimester of pregnancy. Methods and Results: The expression of a selected panel of genes was quantified by reverse transcriptase–polymerase chain reaction in samples of villous trophoblasts obtained from women between 6 and 11 weeks of gestation undergoing elective artificial abortion. We found that the levels of messenger RNA (mRNA) expression of placental growth factor (PlGF), heme oxygenase 1(HO-1), and superoxide dismutase (SOD) increased significantly with gestational age (r = .37, P = .001; r = .24, P =.04; and r = .52, P < .001, respectively). Conversely, the mRNA expression level of fms-like tyrosine kinase 1 (FLT-1) decreased significantly (r = −.30, P = .009). Conclusion: During the early part of the first trimester of pregnancy, the placental gene expression levels of PlGF, HO-1, and SOD increase with gestational age, whereas the expression of FLT-1 decreases. The alteration in this pattern of gene expression in early pregnancy may therefore play an important role in placenta-related disorders such as preeclampsia.
Towards operationalising internal distractibility (Mind Wandering) in adults with ADHD

Objective To investigate whether specific symptoms of attention deficit hyperactivity disorder (ADHD) can help identify ADHD patients with mind wandering. Methods Subjects were adults ages 18–55 of both sexes (n=41) who completed the Mind-Wandering Questionnaire (MWQ) and the ADHD module of the Schedule for Affective Disorders and Schizophrenia for School-Age Children Epidemiologic Version. We used Spearman’s rank correlation and Pearson’s χ2 analyses to examine associations between the ADHD module and the MWQ and receiver operator characteristic (ROC) analyses to evaluate the diagnostic efficiency of the ADHD module. Results Out of the three ADHD domains, the inattentive ADHD scores had the strongest association with the MWQ (total: r s=0.34, df=39, p=0.03; inattentive: r s=0.38, df=39, p=0.02; Hyperactive: r s=0.17, df=39, p=0.28). Correlation analyses between individual items on the ADHD module and the MWQ showed that two inattention items (‘failure to pay attention to detail’ and ‘trouble following instructions’) were positively associated with total scores on the MWQ (p=0.02). These two inattention items had the strongest association with the MWQ (r s=0.45, df=38, p=0.004). ROC analyses showed that the combined score of the two significant inattention items had the highest efficiency (AUC=0.71) in classifying high-level mind wanderers as defined by scores greater than the median split on the MWQ. The combined score of the two inattention items best identified high-level mind wanderers. Conclusion Results suggest a way to operationalise mind wandering using the symptoms of ADHD.
Caloric Restriction, the Traditional Okinawan Diet, and Healthy Aging

Abstract: Long‐term caloric restriction (CR) is a robust means of reducing age‐related diseases and extending life span in multiple species, but the effects in humans are unknown. The low caloric intake, long life expectancy, and the high prevalence of centenarians in Okinawa have been used as an argument to support the CR hypothesis in humans. However, no long‐term, epidemiologic analysis has been conducted on traditional dietary patterns, energy balance, and potential CR phenotypes for the specific cohort of Okinawans who are purported to have had a calorically restricted diet. Nor has this cohort's subsequent mortality experience been rigorously studied. Therefore, we investigated six decades of archived population data on the elderly cohort of Okinawans (aged 65‐plus) for evidence of CR. Analyses included traditional diet composition, energy intake, energy expenditure, anthropometry, plasma DHEA, mortality from age‐related diseases, and current survival patterns. Findings include low caloric intake and negative energy balance at younger ages, little weight gain with age, life‐long low BMI, relatively high plasma DHEA levels at older ages, low risk for mortality from age‐related diseases, and survival patterns consistent with extended mean and maximum life span. This study lends epidemiologic support for phenotypic benefits of CR in humans and is consistent with the well‐known literature on animals with regard to CR phenotypes and healthy aging.
Increased mast cells in the irritable bowel syndrome

Mast cells (MC) release potent mediators which alter enteric nerve and smooth muscle function and may play a role in the pathogenesis of the irritable bowel syndrome (IBS). The aim of this study was to determine if MC were increased in the colon of IBS patients compared to controls. Biopsy specimens were obtained from the caecum, ascending colon, descending colon and rectum of 28 patients: 14 IBS (Rome criteria); seven normal; and seven inflammatory controls. Tissue was stained immunohistochemically using a monoclonal mouse antibody for human mast cell tryptase (AA1). Tissue area occupied by tryptase‐positive MC (volume density of mast cells) was quantified by image analysis. The number of plasma cells, lymphocytes, eosinophils, neutrophils and macrophages were each graded semiquantitatively (0–4) in haematoxylin and eosin stained sections. Mast cell volume density was significantly (P < 0.05) higher in IBS (0.91 ± 0.18; CI 0.79; 1.0) than normal controls (0.55 ± 0.14; CI 0.40; 0.69) in the caecum but not at other sites. Apart from MC, there was no evidence of increased cellular infiltrate in the IBS group. MC were significantly increased in the caecum of IBS patients compared to controls. The multiple effects of the intestinal mast cell alone, or as a participant of a persistent inflammatory response, may be fundamental to the pathogenesis of IBS.
Adolescent Perceptions on the Impact of Growing Up With a Parent With a Disability

 Over the years, a significant amount of research has been conducted on the effects disabilities have on parents, however, there has not been much research conducted on the subject-matter from the perspective of the child. The focus of this study was to investigate the overarching themes expressed by individuals who grew up with a parent with a disability; self-perceptions, relationships, and skillfulness. Within this two-phase study, participants were distributed YCPS (the Young Caregivers Perception Survey) as well as a revised version, the YCPS-R through an online SONA system at a Northeastern university. Consistent findings in this study revealed that participants reported that they had perceived higher levels of independence and overall responsibilities to the family as compared to their friends or other children with parents who are not disabled. Participants also reported high levels of support from siblings, relatives, and friends, as well as felt as though they were able to ask for help from others.
SL(2,Z) action on three-dimensional CFTs and holography

We show that there is a natural action of SL(2, Z) on the two-point functions of the energy momentum tensor and of higher-spin conserved currents in three-dimensional CFTs. The dynamics behind the S-operation of SL(2, Z) is that of an irrelevant current-current deformation and we point out its similarity to the dynamics of a wide class of three-dimensional CFTs. The holographic interpretation of our results raises the possibility that many three-dimensional CFTs have duals on AdS4 with SL(2, Z) duality properties at the linearized level.
THE USE OF FLASHCARD TO IMPROVE THE STUDENTSâ€™ VOCABULARY ACHIEVEMENT

Tujuan penelitian ini adalah untuk mengetahui apakah flashcard dapat digunakan untuk meningkatkan pencapaian kosakata siswa dan untuk menganalisis pelaksanaan pembelajaran melalui flashcard . Populasi dalam penelitian ini adalah siswa kelas dua MTs. Penelitian ini menggunakan Pretest Posttest Satu Kelompok dan para siswa diajar sebanyak tiga kali. Data di analisis menggunakan t-test Pengukuran Berulang. Nilai rata-rata pada pre-test adalah 55,65 meningkat menjadi 74,04 pada post-test. Hasil t-test menunjukkan bahwa t-ratio lebih tinggi daripada t-table (16,183 > 2,069) dengan signifikan level p 2.069) with the level of significant was p < 0.05 and significant 2-tailed was p = 0.000. It can be said that flashcard can be used to improve the studentsâ€™ vocabulary achievement. Â Keywords: flashcard, improve, vocabulary achivement.
Comparison of Walking With Poles and Traditional Walking for Peripheral Arterial Disease Rehabilitation

PURPOSE: The purpose of this study was to compare the effects of a 24-week walking with poles rehabilitation program with a traditional 24-week walking program on physical function in patients with peripheral arterial disease (PAD). METHODS: Patients with PAD (n = 103, age = 69.7 ± 8.9 years, ankle-brachial index < 0.90 or evidence of calcified vessels) were randomized into a rehabilitation program of traditional walking (n = 52) or walking with poles (n = 51). Patients exercised 3 times per week for 24 weeks. Exercise endurance was measured by time walked on a constant work rate treadmill test at 6, 12, and 24 weeks. Perceived physical function was measured by the Medical Outcomes Study Short Form-36 and Walking Impairment Questionnaire. Tissue oxygenation was measured using near-infrared spectroscopy. RESULTS: Patients assigned to the traditional walking group walked longer at 24 weeks than those assigned to the pole walking group (21.10 ± 17.07 minutes and 15.02 ± 12.32 minutes, respectively, P = .037). There were no differences between the groups in tissue oxygenation. However, there was a significant lengthening of time for which it took to reach minimum tissue oxygenation values (P < .001) within the groups on the constant work rate test. There were no differences between the groups in perceived physical function as measured by the Physical Function subscale on the Medical Outcomes Study Short Form-36 or perceived walking distance as measured by the Walking Distance subscale on the Walking Impairment Scale. CONCLUSIONS: Traditional walking was superior to walking with poles in increasing walking endurance on a constant work rate treadmill test for patients with PAD.
Characterization of the E. coli proteome and its modifications during growth and ethanol stress

We set out to provide a resource to the microbiology community especially with respect to systems biology based endeavors. To this end, we generated a comprehensive dataset monitoring the changes in protein expression, copy number, and post translational modifications in a systematic fashion during growth and ethanol stress in E. coli. We utilized high-resolution mass spectrometry (MS) combined with the Super-SILAC approach. In a single experiment, we have identified over 2300 proteins, which represent approximately 88% of the estimated expressed proteome of E. coli and estimated protein copy numbers using the Intensity Based Absolute Quantitation (iBAQ). The dynamic range of protein expression spanned up to six orders of magnitude, with the highest protein copy per cell estimated at approximately 300,000. We focused on the proteome dynamics involved during stationary phase growth. A global up-regulation of proteins related to stress response was detected in later stages of growth. We observed the down-regulation of the methyl directed mismatch repair system containing MutS and MutL of E. coli growing in long term growth cultures, confirming that higher incidence of mutations presents an important mechanism in the increase in genetic diversity and stationary phase survival in E. coli. During ethanol stress, known markers such as alcohol dehydrogenase and aldehyde dehydrogenase were induced, further validating the dataset. Finally, we performed unbiased protein modification detection and revealed changes of many known and unknown protein modifications in both experimental conditions. Data are available via ProteomeXchange with identifier PXD001648.
Comparing Two Basic Methods for Discriminating Between Similar Languages and Varieties

This article describes the systems submitted by the Citius_Ixa_Imaxin team to the Discriminating Similar Languages Shared Task 2016. The systems are based on two different strategies: classification with ranked dictionaries and Naive Bayes classifiers. The results of the evaluation show that ranking dictionaries are more sound and stable across different domains while basic bayesian models perform reasonably well on in-domain datasets, but their performance drops when they are applied on out-of-domain texts.
Thermodynamic and Kinetic Analysis of the Nitrosyl, Carbonyl, and Dioxy Heme Complexes of Neuronal Nitric-oxide Synthase

Mammalian NO synthases catalyze the monooxygenation of l-arginine (l-Arg) to N-hydroxyarginine (NOHA) and the subsequent monooxygenation of this to NO and citrulline. Both steps proceed via formation of an oxyferrous heme complex and may ultimately lead to a ferrous NO complex, from which NO must be released. Electrochemical reduction of NO-bound neuronal nitricoxide synthase (nNOS) oxygenase domain was used to form the ferrous heme NO complex, which was found to be stable only in the presence of low NO concentrations, due to catalytic degradation of NO at the nNOS heme site. The reduction potential for the heme-NO complex was approximately –140 mV, which shifted to 0 mV in the presence of either l-Arg or NOHA. This indicates that the complex is stabilized by 14 kJmol–1 in the presence of substrate, consistent with a strong H-bonding interaction between NO and the guanidino group. Neither substrate influenced the reduction potential of the ferrous heme CO complex, however. Both l-Arg and NOHA appear to interact with bound NO in a similar way, indicating that both bind as guanidinium ions. The dissociation constant for NO bound to ferrous heme in the presence of l-Arg was determined electrochemically to be 0.17 nm, and the rate of dissociation was estimated to be 10–4 s–1, which is much slower than the rate of catalysis. Stopped-flow kinetic analysis of oxyferrous formation and decay showed that both l-Arg and NOHA also stabilize the ferrous heme dioxy complex, resulting in a 100-fold decrease in its rate of decay. Electron transfer from the active-site cofactor tetrahydrobiopterin (H4B) has been proposed to trigger the monoxygenation process. Consistent with this, substitution by the analogue/inhibitor 4-amino-H4B stabilized the oxyferrous complex by a further two orders of magnitude. H4B is required, therefore, to break down both the oxyferrousand ferrous nitrosyl complexes of nNOS during catalysis. The energetics of these processes necessitates an electron donor/acceptor operating within a specific reduction potential range, defining the role of H4B.