Miracle-dz/UniFAR-FTUs huggingface dataset:
Monosomal karyotype routinely defines a poor prognosis subgroup in acute myeloid leukemia and is frequently associated with TP53 deletion

Monosomal karyotype routinely defines a poor prognosis subgroup in acute myeloid leukemia and is frequently associated with TP53 deletion Jean-Baptiste Gaillard, Jean Chiesa, Dorothée Reboul, Anne Arnaud, Sophie Brun, Daniel Donadio, Carole Exbrayat, Stefan Wickenhauser, Pascal Bourquard, Eric Jourdan & Thierry Lavabre-Bertrand a Department of Clinical Cytology and Cytogenetics, Nîmes, France b UMR-CNRS 5247, Montpellier, France c Hematology Laboratory, Nîmes, France d Hématologie et oncologie médicale, Clinique du Parc, Castelnau Le Lez, France e Department of Hematology, Nîmes University Hospital, Nîmes, France Published online: 01 Jun 2015.
Emotion detection in task-oriented spoken dialogues

Detecting emotions in the context of automated call center services can be helpful for following the evolution of the human-computer dialogues, enabling dynamic modification of the dialogue strategies and influencing the final outcome. The emotion detection work reported here is a part of larger study aiming to model user behavior in real interactions. We make use of a corpus of real agent-client spoken dialogues in which the manifestation of emotion is quite complex, and it is common to have shaded emotions since the interlocutors attempt to control the expression of their internal attitude. Our aims are to define appropriate emotions for call center services, to annotate the dialogues and to validate the presence of emotions via perceptual tests and to find robust cues for emotion detection. In contrast to research carried out with artificial data with simulated emotions, for real-life corpora the set of appropriate emotion labels must be determined. Two studies are reported: the first investigates automatic emotion detection using linguistic information, whereas the second concerns perceptual tests for identifying emotions as well as the prosodic and textual cues which signal them. About 11% of the utterances are annotated with non-neutral emotion labels. Preliminary experiments using lexical cues detect about 70% of these labels.
Recovery Following Desflurane Versus Sevoflurane Anesthesia for Outpatient Urologic Surgery in Elderly Females

Background: An unresolved question is the time required for the ability to return to complex tasks following anesthesia. Objectives: This study aims to characterize the severity and duration of cognitive impairment following sevoflurane or desfluane anesthesia after brief surgery using tests of cognitive ability to objectively testing performance. Patients and Methods: This study is a double blinded randomized controlled trial. Patients were randomized to receive either a desflurane or sevoflurane-based anesthetic. On the morning of the surgery the subjects performed baseline cognitive task tests (Mini Mental Status exam, Trail Making Test Part A and B, Digit Symbol Coding, Hopkins Verbal Learning Test, Stroop Color and Word Test to determine baseline cognitive function. Cognitive testing was repeated 30 minutes and 1 hour after surgery whereas Modified Telephone Interview for Cognitive Status (TICS-M) and Memory Aging Telephone Screen (MATS) was used on the following day of surgery. Results: Trail Making Test Part B cognitive test showed statistically significant in comparison for pre and post exposure of anesthetics. This difference was seen in the desflurane group. Other cognitive tests did not show differences on exposure to the anesthetic gases. Conclusions: This study questioned the difference between volatile anesthetic agent’s effects on patients completing a battery of neurocognitive tests attempting to answer if one agent has a more profound effect. Our study shows no statistically significant cognitive decline except for those in the Trail Making Part B in the Desflurane group. This conclusion is limited by the inherent limitations of the study, but does reinforce that the systemic inflammatory response from the surgery contributes cognitive impairment.
Foundation Slab in Interaction with Subsoil

In the paper the experiment results of deformation in foundation slab segment in interaction with subsoil are presented. Pilot measurement is carried out on original subsoil with characteristics which were tested in cooperation with geotechnics specialists. Concrete precast slab with square dimensions 500 mm and with thickness 48 mm made of plain concrete is exposed to vertical load. The tests results are compared with bending moments and deformations analysed according to subsoil models given in Eurocodes using FEM analysis.
Antecedents of Actual Visit Behavior amongst International Tourists in Jordan: Structural Equation Modeling (SEM) Approach

This study which is based on the Theory of Planned Behavior (TPB), examines the relationships between antecedents of revisit intention, perceived risk and actual visit behavior, and the mediating effect of revisit intention in the relationship between perceived behavior control and actual visit behavior. Data was collected from 850 tourists via questionnaires. The data was analyzed using structural equation modeling techniques (Amos 6.0) to evaluate the path model. Additionally, deductive approach was used. The findings highlight four significant direct relationships (1) revisit intention and (2) perceived risk to actual visit behavior; (3) tourist attitude and revisit intention (4) subjective norm and revisit intention. And tow hypothesis were insignificant relationships which are; perceived behavior control and revisit intention and perceived behavior control and actual visit behavior. however, does not have mediating effect. This result demonstrates the ability of the original TPB model to explain international tourists' behavior in Jordan. The findings are discussed in the context of the antecedents of revisit intention and actual visit behavior of international tourists in Jordan.
Axo-Glial Interactions Regulate the Localization of Axonal Paranodal Proteins

Mice incapable of synthesizing the abundant galactolipids of myelin exhibit disrupted paranodal axo-glial interactions in the central and peripheral nervous systems. Using these mutants, we have analyzed the role that axo-glial interactions play in the establishment of axonal protein distribution in the region of the node of Ranvier. Whereas the clustering of the nodal proteins, sodium channels, ankyrinG, and neurofascin was only slightly affected, the distribution of potassium channels and paranodin, proteins that are normally concentrated in the regions juxtaposed to the node, was dramatically altered. The potassium channels, which are normally concentrated in the paranode/juxtaparanode, were not restricted to this region but were detected throughout the internode in the galactolipid-defi- cient mice. Paranodin/contactin-associated protein (Caspr), a paranodal protein that is a potential neuronal mediator of axon-myelin binding, was not concentrated in the paranodal regions but was diffusely distributed along the internodal regions. Collectively, these findings suggest that the myelin galactolipids are essential for the proper formation of axo-glial interactions and demonstrate that a disruption in these interactions results in profound abnormalities in the molecular organization of the paranodal axolemma.
PGC-1α mRNA Level and Oxidative Capacity of the Plantaris Muscle in Rats with Metabolic Syndrome, Hypertension, and Type 2 Diabetes

We examined the fiber profiles and the mRNA levels of peroxisome proliferator-activated receptors (PPARα and PPARδ/β) and of the PPARγ coactivator-1α (PGC-1α) in the plantaris muscles of 15-week-old control (WR), metabolic syndrome (CP), hypertensive (SHR), and type 2 diabetic (GK) rats. The deep regions in the muscles of SHR and GK rats exhibited lower percentages of high-oxidative type I and IIA fibers and higher percentages of low-oxidative type IIB fibers compared with WR and CP rats. The surface regions in the muscles of CP, SHR, and GK rats exhibited lower percentages of high-oxidative type IIA fibers and higher percentages of low-oxidative type IIB fibers compared with WR rats. The muscles of SHR and GK rats had lower oxidative enzyme activity compared with WR rats. The muscles of SHR rats had the lowest PPARδ/β mRNA level. In addition, the muscles of SHR and GK rats had lower PGC-1α mRNA level compared with WR and CP rats. We concluded that the plantaris muscles of rats with hypertension and type 2 diabetes have lower oxidative capacity, which is associated with the decreased level of PGC-1α mRNA.
Molecular Typing of Mastitis-Causing Staphylococcus aureus Isolated from Heifers and Cows

Staphylococcus aureus is among the main etiologic agents of bovine mastitis. A total of 83 isolates of S. aureus from mammary glands of primiparous heifers were collected in the prepartum, calving and during lactation. For lactating cows, a total of 27 isolates of S. aureus from mammary glands were collected during lactation. The samples were taken in two dairy farms located in Sao Paulo State, Brazil. The highest frequency of S. aureus isolation in heifers was at the end of lactation. Strains were typified through Pulsed-field gel electrophoresis (PFGE) and grouped according to patterns of restriction enzyme SmaI. PFGE generated seven clonal profiles that were grouped into three different lineages, with the LA lineage being predominant and identified in heifers, as well as in the cows from the two regions studied. It was concluded that the cows showed a significant source of dispersion of S. aureus. At the first lactation the heifers were infected by the same clonal profiles of S. aureus which were isolated from multiparous lactating cows. The heifers were infected during milking over the months of lactation.
Efficient Evaluation of Aggregates on Bulk Types

A new method for eeciently evaluating queries with aggregate functions is presented. More specii-cally, we introduce a class of aggregate queries where traditional query evaluation strategies in general require O(n 2) time and space in the size of the (at most two) input relations. For this class of aggregate queries our approach needs at most O(n log n) time and linear space. Further, our approach deals not only with relations but with general bulk types like sets, bags, and lists.
COMMENTARY

The educational potential of a computer-controlled patient simulator was tested by the University of Southern California School of Medicine. The results of the experiment suggest unequivocally that there is a twofold advantage to the use of such a simulator in training anesthesiology residents in the skill of endotracheal intubation: (a) residents achieve proficiency levels in a smaller number of elapsed days of training, thus effecting a saving of time in the training of personnel, and (b) residents achieve a proficiency level in a smaller number of trials in the operating room, thus posing significantly less threat to patient safety. The small number of subjects in the study and the large within-group variability were responsible for a lack of statistical significance in 4 of 6 of the analyses performed; however, all differences were substantial and in the hypothesized direction. Thus, despite the narrowly circumscribed tasks to be learned by the experimental subjects, the findings suggest that the use of simulation devices should be considered in planning for future education and training not only in medicine but in other health care professions as well.
Patterns and predictors of violence against children in Uganda: a latent class analysis

Objective To explore patterns of physical, emotional and sexual violence against Ugandan children. Design Latent class and multinomial logistic regression analysis of cross-sectional data. Setting Luwero District, Uganda. Participants In all, 3706 primary 5, 6 and 7 students attending 42 primary schools. Main outcome and measure To measure violence, we used the International Society for the Prevention of Child Abuse and Neglect Child Abuse Screening Tool—Child Institutional. We used the Strengths and Difficulties Questionnaire to assess mental health and administered reading, spelling and maths tests. Results We identified three violence classes. Class 1 (N=696 18.8%) was characterised by emotional and physical violence by parents and relatives, and sexual and emotional abuse by boyfriends, girlfriends and unrelated adults outside school. Class 2 (N=975 26.3%) was characterised by physical, emotional and sexual violence by peers (male and female students). Children in Classes 1 and 2 also had a high probability of exposure to emotional and physical violence by school staff. Class 3 (N=2035 54.9%) was characterised by physical violence by school staff and a lower probability of all other forms of violence compared to Classes 1 and 2. Children in Classes 1 and 2 were more likely to have worked for money (Class 1 Relative Risk Ratio 1.97, 95% CI 1.54 to 2.51; Class 2 1.55, 1.29 to 1.86), been absent from school in the previous week (Class 1 1.31, 1.02 to 1.67; Class 2 1.34, 1.10 to 1.63) and to have more mental health difficulties (Class 1 1.09, 1.07 to 1.11; Class 2 1.11, 1.09 to 1.13) compared to children in Class 3. Female sex (3.44, 2.48 to 4.78) and number of children sharing a sleeping area predicted being in Class 1. Conclusions Childhood violence in Uganda forms distinct patterns, clustered by perpetrator and setting. Research is needed to understand experiences of victimised children, and to develop mental health interventions for those with severe violence exposures. Trial registration number NCT01678846; Results.
Past, Present and Future of the Avogadro number

The definition of Avogadro number (N ) and the current experiments to estimate it, however, both rely on the precise definition of “one gram”. Hence most of the scientists consider it as an ad-hoc number. But in reality it is not the case. In atomic and nuclear physics, atomic gravitational constant is Avogadro number times the Newton’s gravitational constant. Key conceptual link that connects the gravitational force and non-gravitational forces is - the classical force limit, ( 4 ) C F ≅ c G . Ratio of classical force limit and weak force magnitude is ( ) 2 FC FW ≅ N . Thus in this paper authors proposed many unified methods for estimating the Avogadro number.
Different Subcellular Distribution of Caspase-3 and Caspase-7 following Fas-induced Apoptosis in Mouse Liver*

Caspases plays a key role in the execution phase of apoptosis. “Initiator” caspases, such as caspase-8, activate “effector” caspases, such as caspase-3 and -7, which subsequently cleave cellular substrates thereby precipitating the dramatic morphological changes of apoptosis. Following treatment of mice with an agonistic anti-Fas antibody to induce massive hepatocyte apoptosis, we now demonstrate a distinct subcellular localization of the effector caspases-3 and -7. Active caspase-3 is confined primarily to the cytosol, whereas active caspase-7 is associated almost exclusively with the mitochondrial and microsomal fractions. These data suggest that caspases-3 and -7 exert their primary functions in different cellular compartments and offer a possible explanation of the presence of caspase homologs with overlapping substrate specificities. Translocation and activation of caspase-7 to the endoplasmic reticulum correlates with the proteolytic cleavage of the endoplasmic reticular-specific substrate, sterol regulatory element-binding protein 1. Liver damage, induction of apoptosis, activation and translocation of caspase-7, and proteolysis of sterol regulatory element-binding protein 1 are all blocked by the caspase inhibitor, benzyloxycarbonyl-Val-Ala-Asp fluoromethyl ketone (Z-VAD.fmk). Our data demonstrate for the first time the differential subcellular compartmentalization of specific effector caspases following the induction of apoptosis in vivo.
Electroluminescence Studies on Longwavelength Indium Arsenide Quantum Dot Microcavities Grown on Gallium Arsenide

Abstract : A comprehensive study of the electroluminescence of four GaAs/AlGaAs microcavity devices with InAs/GaInAs quantum dot active regions emitting near 1.3 micrometer was conducted. The four molecular beam epitaxial grown samples with AlAs oxide aperture confinement layers were fabricated, characterized, and optically modeled. Optical power transmission of the samples was modeled using Matlab and compared with measured transmission data. Resonant cavity light emitting diodes (RCLEDs) and three vertical cavity surface emitting laser (VCSEL) samples were fabricated and electro-optically characterized over a range of injection currents and temperatures. Devices achieved continuous wave room temperature lasing at 1.28 micrometer with an output power of more than 3 mW, a threshold current of 2.3 mA, and a slope efficiency of 10.3 W/A. The characteristic temperature was 49.4 K and the wall plug efficiency at was a maximum of over 36%. The minimum threshold current, 1.25 mA, was at a temperature of -10 deg C. The cavity resonance wavelength was tuned too short for the peak wavelength of the active region gain curve which limited the temperature at which the VCSELs produced lasing to about room temperature.
Trying to understand the different pieces of the construct validity puzzle of assessment centers: an examination of assessor and assessee effects.

This study examined the effects of assessor-related factors (i.e., type of assessor) and assessee-related factors (i.e., type of assessee profile) on the construct validity of assessment center ratings. In particular, 3 types of assessors (26 industrial/organizational [I/O] psychologists, 20 managers, and 27 students), rated assessee performances that varied according to cross-exercise consistency (i.e., relatively inconsistent vs. relatively consistent) and dimension differentiation (relatively undifferentiated vs. relatively differentiated). Construct validity evidence was established for only one assessee profile and only in the I/O psychologist and managerial samples. More generally, these results indicate that 3 factors (poor design, assessor unreliability, and especially cross-situational inconsistent assessee performances) may explain why construct validity evidence is often not established in operational assessment centers.
Blanket Execution: Dynamic Similarity Testing for Program Binaries and Components

Matching function binaries--the process of identifying similar functions among binary executables--is a challenge that underlies many security applications such as malware analysis and patch-based exploit generation. Recent work tries to establish semantic similarity based on static analysis methods. Unfortunately, these methods do not perform well if the compared binaries are produced by different compiler toolchains or optimization levels. In this work, we propose blanket execution, a novel dynamic equivalence testing primitive that achieves complete coverage by overriding the intended program logic. Blanket execution collects the side effects of functions during execution under a controlled randomized environment. Two functions are deemed similar, if their corresponding side effects, as observed under the same environment, are similar too. We implement our blanket execution technique in a system called BLEX. We evaluate BLEX rigorously against the state of the art binary comparison tool BinDiff. When comparing optimized and un-optimized executables from the popular GNU coreutils package, BLEX outperforms BinDiff by up to 3.5 times in correctly identifying similar functions. BLEX also outperforms BinDiff if the binaries have been compiled by different compilers. Using the functionality in BLEX, we have also built a binary search engine that identifies similar functions across optimization boundaries. Averaged over all indexed functions, our search engine ranks the correct matches among the top ten results 77% of the time.
On the role of interaction in sequential Monte Carlo algorithms

We introduce a general form of sequential Monte Carlo algorithm defined in terms of a parameterized resampling mechanism. We find that a suitably generalized notion of the Effective Sample Size (ESS), widely used to monitor algorithm degeneracy, appears naturally in a study of its convergence properties. We are then able to phrase sufficient conditions for time-uniform convergence in terms of algorithmic control of the ESS, in turn achievable by adaptively modulating the interaction between particles. This leads us to suggest novel algorithms which are, in senses to be made precise, provably stable and yet designed to avoid the degree of interaction which hinders parallelization of standard algorithms. As a byproduct, we prove time-uniform convergence of the popular adaptive resampling particle filter.
Constructions for optimal constant weight cyclically permutable codes and difference families

A cyclically permutable code is a binary code whose codewords are cyclically distinct and have full cyclic order. An important class of these codes are the constant weight cyclically permutable codes. In a code of this class all codewords have the same weight w. These codes have wide applications, e.g., in optical code-division multiple access communication systems and in constructing protocol-sequence sets for the M-active-out-of-T users collision channel without feedback. In this paper we construct optimal constant weight cyclically permutable codes with length n, weight w, and minimum Hamming distance 2w-2. Some of these codes coincide with the well known design called difference family. <<ETX>>
Economics in a Family

T SYMPATHIES and affections of most people are entangled in a web of family relationships. To economists, who are accustomed to modeling society as a set of interactions among self-interested individuals, this fact has often been an embarrassing nuisance. Paul Samuelson’s (1956) classic paper on welfare economics, “Social Indifference Curves,” poses this quandary in a section titled “The Problem of Family Preference: A Parable. ”
AN EFFECT OF BLADE GEOMETRY ON HEAT TRANSFER PERFORMANCE IN STIRRED VESSEL - COAL WATER SLURRY SYSTEM USING COAL GASIFICATION

The effect of the geometrical parameter of blades on heat transfer co-efficient were experimentally studied for agitated vessels using coal slurry in coal gasification. The intensity of hear transfer during mixing of fluids depends on the type of the stirrer, the design of the vessel and conditions of the process. The type and size of the stirrer, as well as its location in the vessel, also affect the rate of hear transfer. In this study, the effect of some important design parameter such as the type of stirrer, angle and shape of blades, number of blades and location of stirrer, etc., were investigated and optimized. Besides, the Taguchi method can successfully be applied to heat transfer investigation to save energy, time and material in experimentation.
Extraction of Si-SiO2 interface trap densities in MOS structures with ultrathin oxides

Si-SiO/sub 2/ interface trap densities can be measured in MOS structures with ultrathin oxides using charge pumping (CP) and small gate pulses. This presents three decisive advantages with respect to the conventional large gate voltage swing approach. First, the extraction is simple as carrier emission does not contribute to the CP signal so that the CP current magnitude directly reflects the interface trap density. Second, the tunneling current is strongly reduced allowing a more easy extraction of the CP signal and third, such a reduction prevents the insulator and the insulator-silicon interface from any degradation. By doing so, Si-SiO/sub 2/ interface trap densities are measured in MOSFETs with oxides which are 1.8 and 1.3 nm thick.