Miracle-dz/UniFAR-FTUs huggingface dataset:
Location-Aware Authorization Scheme for Emergency Response

Effective emergency (such as a hurricane, a building on fire, and so on) response requires accurate, relevant, timely, and location-aware information (e.g., environmental information, health records, and so on). Acquiring information in such critical situations encounters substantial challenges, such as large volume of data processing, unstructured data, privacy, authorized data access, and so forth. Among the issues, access authorization has received little attention. Existing solutions for data authorization either do not scale well or merely consider a Break-the-Glass concept in which a master key is provided to the first responders (FRs) to decrypt the corresponding ciphertext. This may not only enable unauthorized users to access information, but it may also overwhelm FRs by the large volume of accessible data. To jointly address the aforementioned issues, this paper proposes a location-aware authorization scheme that enables FRs to access information provided that they are within a predefined distance from data owners at the time of an emergency. We innovatively integrate attribute-based encryption with broadcast encryption to incorporate dynamic attributes (i.e., location and time) into an access policy. Such attributes act as filters to eliminate data irrelevant to an ongoing emergency. As a result, our scheme provides authorized access to accurate, relevant, timely, and location-aware information. We provide extensive security analysis and performance evaluations to demonstrate the effectiveness of our scheme. The analysis shows that the scheme imposes constant communication and decryption computation overheads. Furthermore, the proposed scheme is proven chosen plain-text attack selectively secure based on m-bilinear Diffie-Hellman exponent assumption. It also addresses the key escrow problem.
Response Selection Errors in Spatial Choice Reaction Tasks

In a “Consistent” spatial choice reaction task, the same spatial relationship obtains between each stimulus and its appropriate response. In an “Inconsistent” task this is not so. The present experiment concerns errors in Inconsistent tasks. Duncan (in press) has suggested that, when two spatial S-R relationships are involved in a task, the dominant type of error is a response bearing to the stimulus the wrong one of the two relationships. Duncan's results, however, may be described by a different generalization. Rabbitt and Vyas (1973) have suggested that confusions occur between responses which, when made correctly, bear similar spatial relationships to their stimuli. In the present experiment, a new Inconsistent task is studied. The results support the account of Duncan (in press) but provide no support for that of Rabbitt and Vyas (1973). Partly on the basis of error results, Duncan (in press) proposed a model of response selection in the spatial choice reaction task. Unlike previous accounts, this model is not based on a set of individual “S—R” associations; operations generating sets of S—R pairs are involved.
An unfinished drama: designing participation for the theatrical dance performance Parcival XX-XI

The partnership of theater and digital media shows much potential for new means of storytelling. Digital scenery can be joined to the performer's action on stage; algorithmic influences can blur the linearity of a drama; interactive technology offers novel means of involving the audience in the creation of the piece. Interaction can thus enhance the dramaturgical possibilities of traditional theater. However, the narrative task also accompanies various new challenges for the designers of such a play. On the basis of our dance performance Parcival XX-XI, we define requirements for making an audience interact in a theatrical play and introduce four interaction-enabling criteria for theatrical performances that use gestural interfaces.
Visualisation for household energy analysis : techniques for exploring multiple variables across scale and geography

The visualisation of large volumes of data can provide rich and meaningful representations that enable users to gain insights quickly and efficiently. Household energy consumer characteristics are explored in this thesis using innovative interactive visualisation techniques. Initial research with energy analysts, from a major UK utility company, investigates visual possibilities and opportunities for future (smart home) energy analytics and explicitly uses creativity techniques for information visualisation requirements gathering. The results, along with exploratory visual analysis combining geodemographic groups and energy consumption, identifes a need for profiling consumers by typical traits. While energy consumption has been a popular topic of research in recent years, there is still limited understanding of the relationship between energy consumption and measurable characteristics of the general population. An investigation of the process of creating an energy-based geodemographic classification led to the proposal and design of a new theoretical framework for visually comparing multivariate data across scale and geography; a necessary step when selecting reliable variables for running clustering algorithms, such as during the geodemographic classification creation process. The framework for including geography and scale in multivariate comparison forms the major contribution of this thesis. This framework is demonstrated and justified through the building of an interactive visualisation prototype, using input variables deemed relevant for consideration for energy-based geodemographic classification. Important transitions in the framework are highlighted in the proposed design, which uses both statistical and spatial representations. The utility of the framework is validated in the context of energy-based geodemographic variable selection where the multivariate geography of the UK is explored. The sensitivities of varying scale and geography { through varying resolution, extent and the calculation of locally weighted summary statistics { are investigated in context and are shown to be important elements to consider during the variable selection process. The broader applicability of the framework is demonstrated through two further scenarios where multivariate visualisation across scale and geography is shown to be important. The research provides a framework and viable solutions through which geographical visual parameter space analysis (gvPSA) can be undertaken. It uses a design science approach that results in a series of artifacts that open up new visualisation possibilities. This project covers a wide topic where the breadth of research options is extensive and many possibilities for continued research are identified.
Tim-3/Galectin-9 Pathway: Regulation of Th1 Immunity through Promotion of CD11b+Ly-6G+ Myeloid Cells

IFN-γ plays a central role in antitumor immunity. T cell Ig and mucin domain (Tim-3) is expressed on IFN-γ–producing Th1 cells; on interaction with its ligand, galectin-9, Th1 immunity is terminated. In this study, we show that transgenic overexpression of Tim-3 on T cells results in an increase in CD11b+Ly-6G+ cells and inhibition of immune responses. Molecular characterization of CD11b+Ly-6G+ cells reveals a phenotype consistent with granulocytic myeloid-derived suppressor cells. Accordingly, we find that modulation of the Tim-3/galectin-9 (Gal-9) pathway impacts on tumor growth. Similarly, overexpression of Tim-3 ligand, Gal-9, results in an increase in CD11b+Ly-6G+ cells and inhibition of immune responses. Loss of Tim-3 restores normal levels of CD11b+Ly-6G+ cells and normal immune responses in Gal-9 transgenic mice. Our data uncover a novel mechanism by which the Tim-3/Gal-9 pathway regulates immune responses and identifies this pathway as a therapeutic target in diseases where myeloid-derived suppressor cells are disadvantageous.
Anxious and depressive avoidance behavior in post-loss psychopathology: a longitudinal study

Background: Avoidance behavior is a central component of cognitive behavioral theories of bereavement-related psychopathology. Yet, its role is still not well understood. This study examined associations of anxious and depressive avoidance behaviors with concurrently and prospectively assessed symptom-levels of prolonged grief disorder (PGD), depression, and posttraumatic stress disorder (PTSD). Design and Methods: Two hundred and ninety-one individuals, confronted with loss maximally three years earlier, completed self-report measures of anxious and depressive avoidance and emotional distress and again completed distress measures one year later. Results: Anxious and depressive avoidance were concurrently associated with symptom-levels of PGD, depression, and PTSD, even when controlling for the shared variance between both forms of avoidance and relevant socio-demographic and loss-related variables. Prospective analyses showed that baseline anxious avoidance predicted increased symptom-levels of PGD, depression, and PTSD one year later, among participants who were in their first year of bereavement but not among those who were beyond this first year. Baseline depressive avoidance was significantly associated with elevated PTSD one year later, irrespective of time since loss. Conclusions: Both anxious and depressive avoidance are associated with different indices of poor long-term adjustment following loss. However, anxious avoidance seems primarily detrimental in the first year of bereavement.
OF COSSERAT ELASTIC SOLIDS AND OTHER GENERALIZED ELASTIC CONTINUA in Continuum models for materials with microstructure

The behavior of solids can be represented by a variety of continuum theories. For example, Cosserat elasticity allows the points in the continuum to rotate as well as translate, and the continuum supports couple per unit area as well as force per unit area. We examine experimental methods for determining the six Cosserat elastic constants of an isotropic elastic solid, or the six Cosserat relaxation functions of a Cosserat viscoelastic solid. We also consider other generalized continuum theories (including micromorphic elasticity, Cowin's void theory, and nonlocal elasticity). Ways of experimentally discriminating among various generalized continuum representations are presented. The applicability of Cosserat elasticity to cellular solids and fibrous composite materials is considered as is the application of related generalized continuum theories.
Studies of independence and conformity: I. A minority of one against a unanimous majority.

The investigations described in this series are concerned with the conditions of independence and lack of independence in the face of group pressure. The abstract temper of present-day theory and investigation in this region rests to a considerable degree on a neglect of the cognitive and emotional experiences that are part of the individual's psychological field. The understanding of social influences will require the study of a wide range of conditions and of the interrelated operations of different psychological functions. A group of seven to nine individuals was gathered in a classroom to take part in what appeared to be a simple experiment in visual discrimination. The subjects were all male, white college students, ranging in age from 17 to 25; the mean age was 20. For certain purposes a large number of critical subjects was required for the present experiment. The present report is based on a total of 123 subjects. The task consisted of the comparison of a standard line with three other lines, one of which was equal in length to the standard. We investigated some of the conditions responsible for independence and lack of independence in the face of arbitrary group pressure. To this end we produced a disagreement between a group and one individual member about a clear and simple issue of fact. The interview, which followed the experimental session, provided qualitative evidence concerning the effects produced by the majority, The particular properties of the experimental situation and their relation to more usual social contradictions were described.
Brexpiprazole I: In Vitro and In Vivo Characterization of a Novel Serotonin-Dopamine Activity Modulator

Brexpiprazole (OPC-34712, 7-{4-[4-(1-benzothiophen-4-yl)piperazin-1-yl]butoxy}quinolin-2(1H)-one) is a novel drug candidate in clinical development for psychiatric disorders with high affinity for serotonin, dopamine, and noradrenaline receptors. In particular, it bound with high affinity (Ki < 1 nM) to human serotonin 1A (h5-HT1A)-, h5-HT2A-, long form of human D2 (hD2L)-, hα1B-, and hα2C-adrenergic receptors. It displayed partial agonism at h5-HT1A and hD2 receptors in cloned receptor systems and potent antagonism of h5-HT2A receptors and hα1B/2C-adrenoceptors. Brexpiprazole also had affinity (Ki < 5 nM) for hD3-, h5-HT2B-, h5-HT7-, hα1A-, and hα1D-adrenergic receptors, moderate affinity for hH1 (Ki = 19 nM), and low affinity for hM1 receptors (Ki > 1000 nM). Brexpiprazole potently bound to rat 5-HT2A and D2 receptors in vivo, and ex vivo binding studies further confirmed high 5-HT1A receptor binding potency. Brexpiprazole inhibited DOI (2,5-dimethoxy-4-iodoamphetamine)-induced head twitches in rats, suggestive of 5-HT2A antagonism. Furthermore, in vivo D2 partial agonist activity of brexpiprazole was confirmed by its inhibitory effect on reserpine-induced DOPA accumulation in rats. In rat microdialysis studies, brexpiprazole slightly reduced extracellular dopamine in nucleus accumbens but not in prefrontal cortex, whereas moderate increases of the dopamine metabolites, homovanillic acid and DOPAC (3,4-dihydroxy-phenyl-acetic acid), in these areas also suggested in vivo D2 partial agonist activity. In particular, based on a lower intrinsic activity at D2 receptors and higher binding affinities for 5-HT1A/2A receptors than aripiprazole, brexpiprazole would have a favorable antipsychotic potential without D2 receptor agonist- and antagonist-related adverse effects. In conclusion, brexpiprazole is a serotonin-dopamine activity modulator with a unique pharmacology, which may offer novel treatment options across a broad spectrum of central nervous system disorders.
Test-Retest Reliability of the Pediatric Clinical Test of Sensory Interaction for Balance (P-CTSIB)

Twenty-four children age four through nice years who were typically developing were given the Pediatric Clinical Test of Sensory Interaction for Balance (P-CTSIB) on tow occasions separated by approximately one week. Test-retest reliability and the magnitudes of difference between test and retest scores were examined for both the Feet-Together and Heel-Toe Positions for the sway and duration scores separately and for the combined sway and duration scores by different sensory conditions. Spearman rank correlation coefficients for the sway and duration scores ranged form very low to moderate. Reliability coefficients improved when examining combined sensory condition scores for a low of . 44 to a high of . 83. Although some of these reliability coefficients were low, they are comparable to those on other published balance tests. The magnitudes of difference between test and retest combined sensory condition scores were minimal for the Feet-Together P-CTSIB. For the Heel-Toe P-CTSIB, the magnitudes of differen.
American Journal of Epidemiology Original Contribution Gains in Body Fat and Vasomotor Symptom Reporting over the Menopausal Transition the Study of Women's Health across the Nation

Although most women report vasomotor symptoms (hot flashes, night sweats) during midlife, their etiology and risk factors are incompletely understood. Body fat is positively associated with vasomotor symptoms cross-sectionally, but the longitudinal relation between changes in body fat and vasomotor symptoms is uncharacterized. The study aim was to examine whether gains in body fat were related to vasomotor symptom reporting over time. Measures of bioelectrical impedance for body fat, reproductive hormones, and reported vasomotor symptoms were assessed annually over 4 years from 2002 to 2006 among 1,659 women aged 47–59 years participating in the Study of Women's Health Across the Nation. Body fat change was examined in relation to vasomotor symptoms by using generalized estimating equations. Body fat gains were associated with greater odds of reporting hot flashes in models adjusted for age, site, race/ethnicity, education, smoking, parity, anxiety, and menopausal status (relative to stable body fat, gain: odds ratio Findings persisted controlling for estradiol, the free estradiol index, or follicle-stimulating hormone concentrations. The relations between body fat changes and night sweats were not statistically significant. Body fat gains are associated with greater hot flash reporting during the menopausal transition. Most women living in the United States report vasomotor symptoms (hot flashes and/or night sweats) during the men-opausal transition (1). Vasomotor symptoms are sensations of intense heat accompanied by sweating and flushing. Usually experienced as bothersome (2), vasomotor symptoms are associated with poorer quality of life (3), mood (4), memory performance (5), and sleep quality (6). Because hormone therapy, the most effective treatment for vasomotor symptoms , has been linked to health risk among certain women (7), the etiology, risk factors, and nonhormonal approaches to managing vasomotor symptoms are the subject of increased scientific interest (8). Obesity and its relation to vasomotor symptoms have been of particular interest. Early work hypothesized that body fat protected against vasomotor symptoms because of the aromatization of androgens to estrogens in fat tissue (9, 10). However, evidence indicates that higher body mass index (1, 11), and body fat in particular (12, 13), is associated with greater vasomotor symptom reporting, primarily hot flashes. These findings are consistent with a thermoregulatory model of vasomotor symptoms in which body fat acts as an insulator, rendering vasomotor symptoms, a putative heat dissipation event, more likely (14).
Accountability in action: the accomplishment of gender, race and class in a meeting of the University of California Board of Regents

In this article, we analyze the proceedings of a meeting that terminated affirmative action policies at the University of California. Employin our recent theoretical reformulation of difference as an accomplishment, we explore participants' means of doing gender, race and class in these deliberations. In discussing our findings, we call attention to their relevance for `formal' and critical discourse analysis.
A new story about folk psychology

I discuss the Narrative Practice Hypothesis (NPH) as a new approach to folk psychology, by highlighting some of the main differences between the NPH and so-called ‘principled approaches’ and elaborating on the importance of the distinction between intentional and propositional attitudes. Furthermore, I address the question whether reason explanations as understood by the NPH constitute a distinctive and autonomous kind of explanation.
Expression of the HsOrc1 gene, a human ORC1 homolog, is regulated by cell proliferation via the E2F transcription factor

The initiation of DNA replication in Saccharomyces cerevisiae requires the action of a multisubunit complex of six proteins known as the origin recognition complex (ORC). The identification of higher eukaryotic homologs of several ORC components suggests a universal role for this complex in DNA replication. We now demonstrate that the expression of one of these homologs is regulated by cell proliferation. Expression of the human Orc1 gene (HsOrc1) is low in quiescent cells, and it is then dramatically induced upon stimulation of cell growth. In contrast, expression of the HsOrc2 gene does not appear to be similarly regulated. We have isolated the promoter that regulates HsOrc1 transcription, and we show that the promoter confers cell growth-dependent expression. We also demonstrate that the cell growth control is largely the consequence of E2F-dependent negative transcription control in quiescent cells. Activation of HsOrc1 transcription following growth stimulation requires G1 cyclin-dependent kinase activity, and forced E2F1 expression can bypass this requirement. These results thus provide a direct link between the initiation of DNA replication and the cell growth regulatory pathway involving G1 cyclin-dependent kinases, the Rb tumor suppressor, and E2F.
HIV‐1 coreceptor preference is distinct from target cell tropism: a dual‐parameter nomenclature to define viral phenotypes

HIV‐1 infection of cells is mediated by engagement between viral envelope glycoproteins (Env) and a receptor complex comprising CD4 and one of two chemokine receptors, CCR5 and CXCR4, expressed on the surface of target cells. Most CD4+‐transformed T cell lines express only CXCR4, but primary lymphocytes and macrophages, the main cellular targets for infection in vivo, express both coreceptors. Cell‐ and viral strain‐specific utilization of these coreceptor pathways, rather than coreceptor expression per se, regulates lymphocyte and macrophage entry and tropism. Virus use of coreceptor[s] (R5, X4, or R5 and X4) and its target cell tropism (lymphocytes, macrophages, and/or transformed T cell lines) are related but distinct characteristics of Envs. A comprehensive classification schema of HIV‐1 Env phenotypes that addresses both tropism and coreceptor use is proposed. Defining Env phenotype based on both parameters is important in the development of entry inhibitors and vaccines, for understanding changes in Env that evolve over time in vivo, and for discerning differences among viral species that underlie aspects of pathogenesis and transmission. Recognizing how tropism is related to, yet differs from, coreceptor selectivity is critical for understanding the mechanisms by which these viral characteristics impact pathogenesis.
Barriers to Interdisciplinarity: Disciplinary discourses and student learning

Interdisciplinary study is hard to achieve and to sustain. Students are faced with major challenges in working in and across several disciplines. These difficulties reflect both contrasting disciplinary cognitive structures and the distinctive cultures that have emerged in different disciplines. This paper draws on the work of Kolb and others to clarify some of these problems and to suggest ways of helping students to become more self-aware as learners and more capable of effecting these moves between disciplines.