Miracle-dz/UniFAR-FTUs huggingface dataset:
Collecting and Analyzing Bots in a Systematic Honeynet-based Testbed Environment

Networks of compromised machines called botnets are one of the most threatening adversaries over the Internet due in large part to the difficulty of identifying botnet traffic patterns. We have witnessed that existing signature-based detection and protection methods are ineffective in dealing with new unknown bots. By slightly modifying the code of an existing bot, bot commanders can bypass most signature based mechanisms. We believe that by analyzing bot traffic for malicious patterns, it is possible to develop a taxonomy of bot characteristics and in turn use these characteristics to develop risks which will ultimately be used in the decision making process of allowing or blocking traffic. In this paper, we introduce our Honeynet-based Bot Analysis Architecture which is the first step towards our Risk-Aware Network-centric Malware Detection and Prevention Framework. We discuss our current architecture and how it could be realized towards identifying unknown bots and other malware. In addition, we discuss our results and lessons learned from this work. finally allow an adversary to control compromised machines in use (3, 4, and 5). In this paper, we describe our Honeynet-based Bot Analysis Architecture which includes collecting bots, running them on an offline simulated network, and installing them on an open analysis system to connect with their command and control center. We use the actual collected bots to connect to their command and control centers instead of simulated attack bots, sometimes called "drones". We use our analysis template to discover characteristics of each individual bot. This template has proved to be an invaluable learning tool for students to interact with malware in the wild. In the future such characteristics will be used to determine relevant risk values of specific network patterns for making signature-based detection more effective. The rest of the paper is organized as follows. Section II discusses background information and related works. The Honeynet-based Bot Analysis Architecture is presented in Section III. In Section IV, we discuss our analysis method along with the results. Section V concludes this paper with a brief description of future work.
The Website Schema

ABSTRACT The website schema is conceptualized as the consumer’s set of beliefs about information locations, and routes to those locations, on a website. A meta-analysis of three studies, one of them with a student sample and two with consumer samples, provides evidence that congruence between a consumer’s website schema and the actual structure of a particular site is associated with the site being rated easier to navigate, a more favorable attitude toward brands advertised on the site, and higher quality brand decisions. These studies provide evidence of the importance of the website schema for understanding consumer response to websites.
The Migration–Immigration Link in Canada's Gateway Cities: A Comparative Study of Toronto, Montreal, and Vancouver

In this paper we explore the links between internal migration and international immigration in Canada's three largest metropolitan areas. In particular, we use a place-specific approach to test the displacement hypothesis that the migration behaviour of the less-well-educated native-born population is sensitive to the inflows of immigrants. Based on analyses of microdata from five consecutive censuses covering the period from 1981 to 2001, we find that the migration–immigration relationships are complex, often subtle, and inconsistent across the three cities. Growth in the immigrant population is correlated with an increased out-migration rate among the less-well-educated native-born population, but only in Toronto and Vancouver. This correlation, however, is not independent of changes in housing prices. We also find no consistent support for an alternative hypothesis that economic restructuring accounts for the net out-migration from immigrant gateway cities.
Personal competences and outdoor development for managers

Describes the use of outdoor management development exercises in relation to the issue of personal competences. Presents findings of a pilot study by the University of Glasgow Business School, which is researching the relationship between traditional and vocational models of learning. Finds that in general, there are potential personal benefits for participants to explore their managerial skills through outdoor development exercises, but that research needs to continue to ensure a greater emphasis on self‐confidence, drive, personal learning and development.
Prospective memory performance in preschoolers: Inhibitory control matters

The present study focuses on prospective memory in preschoolers. We specifically investigated the effects of age, retrospective memory, and task interruption on prospective memory performance. In the first experiment, testing 60 children aged 3, 4 and 5 years with a prospective memory task that required active ongoing task interruption we obtained an age effect indicating better prospective memory performance for the two older cohorts. Varying retrospective memory load did influence prospective memory response time but did not affect prospective memory accuracy. However, retrospective memory performance showed an age effect and individual differences in retrospective memory ability were related to individual differences in prospective memory performance, even after partialling age. In the second study, we applied a prospective memory task that did not require active ongoing task interruption. Here, testing 62 children aged 3, 4 and 5 years we still found an age effect in retrospective memory but neither an effect of age nor retrospective memory on prospective memory performance. It is concluded that preschoolers even at the age of 3 years can perform prospective memory tasks to a certain extent. Moreover, while retrospective memory still seems to be somewhat related to prospective memory in preschoolers, inhibitory control required for ongoing task interruption seems to be an especially important factor influencing task performance in preschoolers.
Functional analysis of human CNGA3 mutations associated with colour blindness suggests impaired surface expression of channel mutants A3R427C and A3R563C

Mutations in the CNGA3 gene have been associated with complete and incomplete forms of total colour blindness (achromatopsia), a disorder characterized by reduced visual acuity, lack of colour discrimination, photophobia and nystagmus. CNGA3 encodes the A‐subunit of the cone photoreceptor cyclic nucleotide‐gated (CNG) channel, an essential component of the phototransduction cascade. Here we report the identification of three new CNGA3 mutations in patients with achromatopsia. To assess the pathogenicity of these newly identified and four previously reported mutations, mutant CNGA3 channels were heterologously expressed in a human embryonic kidney cell line (HEK293 cells) and functionally analysed using calcium imaging. Channels with the mutations R427C and R563C showed a response in imaging experiments and were subsequently characterized in‐depth with the patch‐clamp technique. The mutant channels were analysed as homooligomers and also as heterooligomers with the wild‐type B‐subunit present in native channels. Overall, cyclic guanosine monophosphate (cGMP) maximum currents of mutant channels were profoundly reduced in homo‐ and heteromers. Treatment with the chemical chaperone glycerol effectively increased macroscopic currents, presumably by enhancing surface expression of mutant channels as confirmed by immunocytochemistry. These results suggest decreased channel density in the cell membrane due to impaired folding or trafficking of the channel protein as the main pathogenic effect of the mutations R427C and R563C. Moreover, A3R427C homomers showed distinctly increased cGMP and cyclic adenosine monophosphate (cAMP) sensitivities as well as cAMP fractional currents that were raised to over 90% of cGMP maximum currents. Co‐expression of A3R427C with the B3 subunit compensated for most of these aberrant properties, apart from the reduced cGMP maximum currents.
Perceived Organizational Ethics and the Ethical Decisions of Sales and Marketing Personnel

Using a scenario-based approach, this study analyzed data collected from marketers with sales backgrounds and investigated the impact of perceived organizational ethics on their ethical issue recognition, ethical judgments, and ethical behavioral intentions. The results indicated that perceived organizational ethics, which was operationalized with two separate measures, was positively related to both the ethical judgments and expressed behavioral intentions of respondents. Further, ethical issue recognition was positively associated with ethical judgments and expressed behavioral intentions, and ethical judgments were positively related to ethical behavioral intentions. The findings suggest that, in order to enhance sales professionals’ ethical reasoning, organizations should focus on developing an ethical context that is relevant to the issues confronted by sales professionals in their work and that is as specific as possible with regard to these ethical dilemmas.
Esthesioneuroblastoma, Neuroendocrine Carcinoma, and Sinonasal Undifferentiated Carcinoma: Differentiation in Diagnosis and Treatment

Abstract Introduction Malignant sinonasal tumors comprise less than 1% of all neoplasms. A wide variety of tumors occurring primarily in this site can present with an undifferentiated or poorly differentiated morphology. Among them are esthesioneuroblastomas, sinonasal undifferentiated carcinomas, and neuroendocrine carcinomas. Objectives We will discuss diagnostic strategies, recent advances in immunohistochemistry and molecular diagnosis, and treatment strategies. Data Synthesis These lesions are diagnostically challenging, and up to 30% of sinonasal malignancies referred to the University of Texas MD Anderson Cancer Center are given a different diagnosis on review of pathology. Correct classification is vital, as these tumors are significantly different in biological behavior and response to treatment. The past decade has witnessed advances in diagnosis and therapeutic modalities leading to improvements in survival. However, the optimal treatment for esthesioneuroblastoma, sinonasal undifferentiated carcinoma, and neuroendocrine carcinoma remain debated. We discuss advances in immunohistochemistry and molecular diagnosis, diagnostic strategies, and treatment selection. Conclusions There are significant differences in prognosis and treatment for esthesioneuroblastoma, neuroendocrine carcinoma, and sinonasal undifferentiated carcinoma. Recent advances have the potential to improve oncologic outcomes but further investigation in needed.
Treating female infertility and improving IVF pregnancy rates with a manual physical therapy technique.

CONTEXT Infertility and pregnancy. OBJECTIVE To assess the effectiveness of site-specific manual soft tissue therapy in (1) facilitating natural fertility and (2) improving in vitro fertilization (IVF) pregnancy rates in women with histories indicating abdominopelvic adhesion formation. DESIGN AND INTERVENTION Pursuant to 2 promising pilot studies, 53 infertile, premenopausal patients received a 10- to 20-hour series of site-specific manual physical therapy treatments. Seventeen patients hoped to achieve a natural pregnancy; 36 planned to undergo IVF within 15 months. The primary criteria for inclusion in the studies were the inability to conceive following a minimum of 12 months of unprotected intercourse and suspected or confirmed pelvic adhesions due to abdominal and/or pelvic surgery, infectious or inflammatory disease (eg, endometriosis, PID), or trauma. Treatments were specifically designed to address biomechanical dysfunctions of the pelvis, sacrum, and coccyx and restricted soft tissue and visceral mobility due to adhesions or microadhesions affecting the reproductive organs and adjacent structures. MAIN OUTCOME MEASURES (1) Natural fertility group: pregnancy within 1 year of therapy and subsequent full-term delivery; (2) Pre-IVF group: pregnancy (via transfer of fresh embryos from nondonor eggs) within 15 months of the last manual treatment date. RESULTS Natural fertility group: Of the 14 patients available for follow-up (ages 25 to 44; mean, 33.5 years), 10 (71.4%) became pregnant within 1 year, and 9 (64.3%) reported full-term deliveries. Three of the 9 women who delivered reported a subsequent pregnancy, suggesting that the treatment protocol might have lasting effects. Two women have had a second live birth delivery; and the third is still pregnant. Pre-IVF group: Of the 25 patients available for follow-up (ages 28 to 44; mean, 36 years), clinical pregnancies were documented in 22 of 33 embryo transfers vs the US Centers for Disease Control and Prevention (CDC) 2001 age-adjusted expected number of 12.7 (P < .001). The estimated odds ratio for a successful pregnancy in a cycle (manual treatment: no treatment) is 3.20 (95% confidence interval = 1.55-8.4). CONCLUSIONS The data trend across these studies suggests that this innovative site-specific protocol of manual soft-tissue therapy facilitates fertility in women with a wide array of adhesion-related infertility and biomechanical reproductive organ dysfunction. The therapy, designed to improve function by restoring visceral, osseous, and soft-tissue mobility, is a nonsurgical, noninvasive manual technique with no risks and few, if any, adverse side effects or complications. As such, it should be considered a new adjunct to existing medical infertility treatments.
Investor Sentiment and Asset Valuation

The link between asset valuation and investor sentiment is the subject of considerable debate in the profession. If excessive optimism drives prices above intrinsic values, periods of high sentiment should be followed by low returns, as market prices revert to fundamental values. Using survey data on investor sentiment, we provide evidence that sentiment affects asset valuation. Market pricing errors implied by an independent valuation model are positively related to sentiment. Future returns over multiyear horizons are negatively related to sentiment. These results are robust to the inclusion of other variables that have been shown to forecast stock returns.
Gene expression profiles and protein–protein interaction network analysis in AIDS patients with HIV-associated encephalitis and dementia

Central nervous system dysfunction is an important cause of morbidity and mortality in patients with human immunodeficiency virus type 1 (HIV-1) infection and acquired immunodeficiency virus syndrome (AIDS). Patients with AIDS are usually affected by HIV-associated encephalitis (HIVE) with viral replication limited to cells of monocyte origin. To examine the molecular mechanisms underlying HIVE-induced dementia, the GSE4755 Affymetrix data were obtained from the Gene Expression Omnibus database and the differentially expressed genes (DEGs) between the samples from AIDS patients with and without apparent features of HIVE-induced dementia were identified. In addition, protein–protein interaction networks were constructed by mapping DEGs into protein–protein interaction data to identify the pathways that these DEGs are involved in. The results revealed that the expression of 1,528 DEGs is mainly involved in the immune response, regulation of cell proliferation, cellular response to inflammation, signal transduction, and viral replication cycle. Heat-shock protein alpha, class A member 1 (HSP90AA1), and fibronectin 1 were detected as hub nodes with degree values >130. In conclusion, the results indicate that HSP90A and fibronectin 1 play important roles in HIVE pathogenesis.
Economics of Horizontal Integration in Poultry Industry in South-West Nigeria

The broad objective of this study is to analyze the economics of horizontal integration in poultry production in some selected local government areas in south-west, Nigeria. Data was collected from 61 fish farmers, 40 poultry farmers and 53 integrated fish and poultry farms, making a sample size of 154 farmers using purposive-snowball sampling process. Descriptive statistics, gross margin analysis and stochastic cost frontier were employed for data analysis. Analysis of socio-economic characteristics shows that most of the farmers in the study area are males, young within the age range of 30-<60 years and had formal education. Most of the farms are solely owned and some of the farmers are part-time farmers. Analysis of cost shows that feed account for 55.8, 68.2 and 78.9% of variable cost of production for sole fish farming, integrated poultry and fishery as well as sole poultry farming respectively. Followed closely in the same order is the cost of labour which account for 26, 6.4 and 3.7% cost of production respectively. The gross margin analysis shows that horizontally integrated poultry farms have highest gross margin (₦ 1,994,792.88) while the sole fish enterprise records the least gross margin of ₦ 556,516.32. This confirms the economic importance of horizontal integration in poultry industry in terms of profitability. The price of eggs, flock size, stocked fingerlings, quantity of feed and cost of intermediate materials are the explanatory variables that influence the production cost while age of the farmers, vertical integration and sole fish farming are the determinants of economic efficiency.
Vitamin D supplementation in the ICU patient

Purpose of reviewRecent findings suggest that vitamin D is a marker for outcomes in critical illness. The purpose of this review is to summarize current biological, observational and interventional evidence in the critically ill. Recent findingsBoth biological and observational studies support the role of vitamin D deficiency in adverse critical illness outcomes. Interventional trials of critically ill patients show that to improve vitamin D status, high-dose vitamin D3 is required. Critically ill patients have a relatively blunted response to vitamin D supplementation compared to the general outpatient population. Toxicity from high-dose vitamin D in trials in the critically ill has been limited to mild hypercalcemia. Recent evidence suggests that treatment of severely vitamin D-deficient critically ill patients with high-dose vitamin D early in the ICU course may improve mortality. SummaryVitamin D deficiency is a potentially modifiable marker for adverse outcomes in critical illness and critical illness survivors. Vitamin D supplementation is inexpensive and appears safe in critical illness trials. A well powered interventional trial is required to determine the definitive answer regarding the role of vitamin D supplementation in the improvement of critical care outcomes. Until such data are available, a cautious approach to correction of vitamin D status in the ICU is warranted.
Shaping the boys' agenda: the backlash blockbusters

The boys’ debate internationally is being fuelled by a range of texts on boys and masculinity. Many of the most popular texts are situated firmly within a backlash politics. These politics suggest that boys are the new ‘victims’ of schooling and that the girls’ agenda in schooling is a completed one. This paper will challenge the arguments contained within a number of the most recent of these ‘backlash blockbusters’. The paper will argue that, rather than boys being placed on the educational agenda in the status of victims, the ways in which dominant forms of masculinities and the harms they cause many girls and some boys need to be addressed.
Circular Intermediates of Recombinant Adeno-Associated Virus Have Defined Structural Characteristics Responsible for Long-Term Episomal Persistence in Muscle Tissue

ABSTRACT Adeno-associated viral (AAV) vectors have demonstrated great utility for long-term gene expression in muscle tissue. However, the mechanisms by which recombinant AAV (rAAV) genomes persist in muscle tissue remain unclear. Using a recombinant shuttle vector, we have demonstrated that circularized rAAV intermediates impart episomal persistence to rAAV genomes in muscle tissue. The majority of circular intermediates had a consistent head-to-tail configuration consisting of monomer genomes which slowly converted to large multimers of >12 kbp by 80 days postinfection. Importantly, long-term transgene expression was associated with prolonged (80-day) episomal persistence of these circular intermediates. Structural features of these circular intermediates responsible for increased persistence included a DNA element encompassing two viral inverted terminal repeats (ITRs) in a head-to-tail orientation, which confers a 10-fold increase in the stability of DNA following incorporation into plasmid-based vectors and transfection into HeLa cells. These studies suggest that certain structural characteristics of AAV circular intermediates may explain long-term episomal persistence with this vector. Such information may also aid in the development of nonviral gene delivery systems with increased efficiency.
Using ROBDDs for Inference in Bayesian Networks with Troubleshooting as an Example

When using Bayesian networks for modelling the behavior of man-made machinery, it usually happens that a large part of the model is deterministic. For such Bayesian networks the deterministic part of the model can be represented as a Boolean function, and a central part of belief updating reduces to the task of calculating the number of satisfying configurations in a Boolean function. In this paper we explore how advances in the calculation of Boolean functions can be adopted for belief updating, in particular within the context of troubleshooting. We present experimental results indicating a substantial speed-up compared to traditional junction tree propagation.
Can Intensive Care Staff See Their Patients? An Improved Visibility Analysis Methodology

This is a study of the spatial properties of environments to which habitual users are attuned. The particular properties under consideration are those that affect visual fields. The authors tested the proposition that the impact of spatial organization becomes clearer when people focus on a prespecified set of visual targets. Empirical observations were performed to understand how medical staff members occupy space in an intensive care unit. The close correspondence between targeted visibility pattern and aggregated behavior patterns indicates that medical staff members are attentive to the relative visual information of environments. With the refinement of the targeted visibility analysis, the authors can better explain people’s spatial choices and routine behaviors. Furthermore, this study gives an opportunity and related measures for health care facility designers to specify the visual structures of important behavioral effects.
Exploiting Digital DNA for the Analysis of Similarities in Twitter Behaviours

Recently, DNA-inspired online behavioral modeling and analysis techniques have been proposed and successfully applied to a broad range of tasks. In this paper, we employ a DNA-inspired technique to investigate the fundamental laws that drive the occurrence of similarities among Twitter users. The achieved results are multifold. First, we demonstrate that, despite apparently showing little to no similarities, the online behaviors of Twitter users are far from being uniformly random. Then, we perform a set of simulations to benchmark different behavioral models and to identify the models that better resemble human behaviors in Twitter. Finally, we demonstrate that the number and the extent of behavioral similarities within a group of Twitter users obey a log-normal distribution. Our results shed light on the fundamental properties that drive behaviors of groups of Twitter users, through the lenses of DNA-inspired behavioral modeling techniques. Our datasets are publicly available to the scientific community to further explore analytics of online behaviors.