Miracle-dz/UniFAR-FTUs huggingface dataset:
A Distinctive Set of Genes Is Upregulated During the Inflammation-Carcinoma Sequence in Mouse Stomach Infected by Helicobacter felis

Helicobacter pylori infects over half the population worldwide and is a leading cause of chronic gastritis and gastric cancer. However, the mechanism by which this organism induces inflammation and carcinogenesis is not fully understood. In the present study we used insulin-gastrin (INS-GAS) transgenic mice that fully develop gastric adenocarcinoma after infection of H. pylori-related Helicobacter felis. Histological examination revealed that more than half of those mice developed invasive adenocarcinoma after 8 months of infection. These carcinomas were stained by NCC-ST-439 and HECA-452 that recognize 6-sulfated and non-sulfated sialyl Lewis X. Lymphocytic infiltration predominantly to submucosa was observed in most H. felis-infected mice, and this was associated with the formation of peripheral lymph node addressin (PNAd) on high endothelial venule (HEV)-like vessels detected by MECA-79. Time-course analysis of gene expression by using gene microarray revealed upregulation of several inflammation-associated genes including chemokines, adhesion molecules, surfactant protein D (SP-D), and CD74 in the infected stomach. Immunohistochemical analysis demonstrated that SP-D is expressed in hyperplasia and adenocarcinoma whereas CD74 is expressed in adenocarcinoma in situ and invasive carcinoma. These results as a whole indicate that H. felis induces HEV-like vessels and inflammation-associated chemokines and chemokine receptors, followed by adenocarcinoma formation.
High Virulence of Wolbachia after Host Switching: When Autophagy Hurts

Wolbachia are widespread endosymbionts found in a large variety of arthropods. While these bacteria are generally transmitted vertically and exhibit weak virulence in their native hosts, a growing number of studies suggests that horizontal transfers of Wolbachia to new host species also occur frequently in nature. In transfer situations, virulence variations can be predicted since hosts and symbionts are not adapted to each other. Here, we describe a situation where a Wolbachia strain (wVulC) becomes a pathogen when transfected from its native terrestrial isopod host species (Armadillidium vulgare) to another species (Porcellio d. dilatatus). Such transfer of wVulC kills all recipient animals within 75 days. Before death, animals suffer symptoms such as growth slowdown and nervous system disorders. Neither those symptoms nor mortalities were observed after injection of wVulC into its native host A. vulgare. Analyses of wVulC's densities in main organs including Central Nervous System (CNS) of both naturally infected A. vulgare and transfected P. d. dilatatus and A. vulgare individuals revealed a similar pattern of host colonization suggesting an overall similar resistance of both host species towards this bacterium. However, for only P. d. dilatatus, we observed drastic accumulations of autophagic vesicles and vacuoles in the nerve cells and adipocytes of the CNS from individuals infected by wVulC. The symptoms and mortalities could therefore be explained by this huge autophagic response against wVulC in P. d. dilatatus cells that is not triggered in A. vulgare. Our results show that Wolbachia (wVulC) can lead to a pathogenic interaction when transferred horizontally into species that are phylogenetically close to their native hosts. This change in virulence likely results from the autophagic response of the host, strongly altering its tolerance to the symbiont and turning it into a deadly pathogen.
ASCA Observation of an “X-Ray Shadow” in the Galactic Plane

The diffuse X-ray background (DXB) emission near the Galactic plane (l,b ~ 25.°6,0.°78) has been observed with ASCA. The observed region is toward a Galactic molecular cloud that was recently reported to cast a deep X-ray shadow in the 0.5-2.0 keV band DXB. The selection of this particular region is intended to provide a constraint on the spatial distribution of the DXB emission along the line of sight: i.e., the molecular cloud is optically thick at less than 2 keV, so the bulk of the observed soft X-rays must originate in the foreground of the cloud, which is at ~3 kpc from the Sun. In the 0.8-9.0 keV band, the observed spectrum is primarily from multiple components of thermal plasmas. We report here a detection of soft X-ray (0.5-2 keV) emission from an ~107 K thermal plasma. Comparisons with the ROSAT data suggest that this soft X-ray emission is absorbed by NH = 1-3 × 1021 cm-2, which implies a path-length through the soft X-ray-emitting regions of ≲1 kpc from the Sun.
Differing Dynamics of Intrapersonal and Interpersonal Coordination: Two-finger and Four-Finger Tapping Experiments

Finger-tapping experiments were conducted to examine whether the dynamics of intrapersonal and interpersonal coordination systems can be described equally by the Haken—Kelso—Bunz model, which describes inter-limb coordination dynamics. This article reports the results of finger-tapping experiments conducted in both systems. Two within-subject factors were investigated: the phase mode and the number of fingers. In the intrapersonal experiment (Experiment 1), the participants were asked to tap, paced by a gradually hastening auditory metronome, looking at their fingers moving, using the index finger in the two finger condition, or the index and middle finger in the four-finger condition. In the interpersonal experiment (Experiment 2), pairs of participants performed the task while each participant used the outside hand, tapping with the index finger in the two finger condition, or the index and middle finger in the four-finger condition. Some results did not agree with the HKB model predictions. First, from Experiment 1, no significant difference was observed in the movement stability between the in-phase and anti-phase modes in the two finger condition. Second, from Experiment 2, no significant difference was found in the movement stability between the in-phase and anti-phase mode in the four-finger condition. From these findings, different coordination dynamics were inferred between intrapersonal and interpersonal coordination systems against prediction from the previous studies. Results were discussed according to differences between intrapersonal and interpersonal coordination systems in the availability of perceptual information and the complexity in the interaction between limbs derived from a nested structure.
Performance analysis of economic MPC with self-tuning terminal cost

In this paper, we further analyze an economic model predictive control (MPC) algorithm with self-tuning terminal cost, which was recently proposed in [1]. It is shown that if a generalized terminal region constraint instead of a generalized terminal equality constraint is used, improved closed-loop asymptotic average performance bounds can be obtained. In particular, in contrast to the results in [1], these bounds can be obtained a priori. We discuss how the necessary parameters for the generalized terminal region setting can be calculated, and we illustrate our findings with a numerical example.
graft rejection in allogeneic bone marrow transplant recipients Ligation of OX 40 ( CD 134 ) regulates graft-versus-host disease ( GVHD )

http://bloodjournal.hematologylibrary. org/content/101/9/3741.full. html Updated information and services can be found at: (1844 articles) Transplantation  (1930 articles) Signal Transduction  (4939 articles) Immunobiology  Articles on similar topics can be found in the following Blood collections http://bloodjournal.hematologylibrary. org/site/misc/rights.xhtml#repub_requests Information about reproducing this article in parts or in its entirety may be found online at: http://bloodjournal.hematologylibrary. org/site/misc/rights.xhtml#reprints Information about ordering reprints may be found online at: http://bloodjournal.hematologylibrary. org/site/subscriptions/index.xhtml Information about subscriptions and ASH membership may be found online at:
Two Clinical Strains of Klebsiella pneumoniae Carrying Plasmid-Borne blaIMP-4, blaSHV-12, and armA Isolated at a Pediatric Center in Shanghai, China

ABSTRACT Two cases of pulmonary infection due to strains of multidrug-resistant Klebsiella pneumoniae were investigated. Beta-lactamase determinants, such as blaIMP-4 and blaSHV-12, and the 16S rRNA methyltransferase-encoding gene armA were detected in these plasmid-bearing organisms. The integron-borne blaIMP-4 and armA contained intervening sequences highly related to those of a Vibrio cholerae O139 plasmid found in Hangzhou, China.
A PSYCHOMETRIC STUDY OF 34 PATIENTS AFFLICTED WITH SPASMODIC TORTICOLLIS

The clinical and psychometric comparison of two groups of patients, one with spasmodic torticollis, the other with operated herniated disc, showed closely related psychological profiles. The most important perturbations are found in spasmodic torticollis and seem related to the disease's chronicity. In no case was a predominant hysteric structure found. The results of these investigations on the disorder's etiology are discussed.
Anatomic Factors that May Predispose Female Athletes to Anterior Cruciate Ligament Injury

Female athletes are 2 to 10 times more likely to injure their anterior cruciate ligaments (ACL) than male athletes. There has been greater recognition of this gender discrepancy because female participation in competitive athletics has increased. Previous investigators have divided risk factors into hormonal, neuromuscular response, and anatomic subgroups. Gender variation within these groups may help explain the higher incidence of ACL injury in women. The purpose of this article is to review research examining female-specific anatomy that may predispose women to ACL injury. Specifically, we discuss how women may have increased tibial and meniscal slopes, narrower femoral notches, and smaller ACL, which may place the ACL at risk from injury. These anatomic factors, combined with other female-specific risk factors, may help physicians and researchers better understand why women appear to be more prone to ACL injury.
An Electron Microscopic Study of Erythrophagocytosis

The present study describes a submicroscopic surface fragmentation of erythrocytes which occurs in the ascitic fluid of rats bearing the Novikoff ascites hepatoma. The resulting fragments attach to the surface of macrophages and are phagocytized by pseudopod formation. Plasma membrane in the region of these phagocytosis vacuoles appears to condense into electron-opaque material, suggesting an alteration in its physicochemical state. Stages in intracellular digestion of intact erythrocytes or small fragments within the phagocytosis vacuoles are illustrated; no particles resembling ferritin are observed. The phagocytosis vacuoles possess high levels of acid phosphatase activity. They may be called phagosomes, a type of lysosome. There is no indication of a connection between phagosomes and other formed cytoplasmic organelles. Small vacuoles of the order of 80 mµ in diameter, which may represent pinocytosis vacuoles, are present in the cytoplasm and some appear to be in contact with the phagosome membrane, reminiscent of observations of Rose with HeLa cells.
Relationship Between Household Nonresponse, Demographics, and Unemployment Rate in the Current Population Survey.

Introduction In the Current Population Survey, a household survey from which labor force estimates are produced, selected housing units remain in sample during a 16-month period. The households are interviewed during the first 4 and last 4 months of this period. These interview months are referred to as “month-in-sample” (MIS) 1 to 8. Matching households between months allows an analysis of the relationship between nonresponse and estimates of the employment rate. Since change in employment may be related to the household’s participation, the estimates of employment status may be affected. A recent study by Tucker and Kojetin (1997) showed that unemployment rates were related to nonresponse in the CPS. “Converts” (households that do not participate in the prior month) do not completely make up for the number of “Attriters” (households that do not participate in the following month), so their relative effect may not be offset. Moreover, they may differ on important characteristics, e.g.; race, ethnicity, or gender. The current study examines the nature of this relationship through an analysis of demographics and nonresponse and their resulting effect on labor force estimates.
Clustering of the AKARI NEP Deep Field 24 μm Selected Galaxies

Aims. We present a method of selection of 24 μ m galaxies from the AKARI north ecliptic pole (NEP) deep field down to 150 μ Jy and measurements of their two-point correlation function. We aim to associate various 24 μ m selected galaxy populations with present day galaxies and to investigate the impact of their environment on the direction of their subsequent evolution. Methods. We discuss using of Support Vector Machines (SVM) algorithm applied to infrared photometric data to perform star-galaxy separation, in which we achieve an accuracy higher than 80%. The photometric redshift information, obtained through the CIGALE code, is used to explore the redshift dependence of the correlation function parameter (r 0 ) as well as the linear bias evolution. This parameter relates galaxy distribution to the one of the underlying dark matter. We connect the investigated sources to their potential local descendants through a simplified model of the clustering evolution without interactions. Results. We observe two different populations of star-forming galaxies, at z med ∼ 0.25, z med ∼ 0.9. Measurements of total infrared luminosities ( L TIR ) show that the sample at z med ∼ 0.25 is composed mostly of local star-forming galaxies, while the sample at z med ∼ 0.9 is composed of luminous infrared galaxies (LIRGs) with L TIR ∼ 10 11.62 L ⨀ . We find that dark halo mass is not necessarily correlated with the L TIR : for subsamples with L TIR = 10 11.15 L ⨀ at z med ∼ 0.7 we observe a higher clustering length ( r 0 = 6.21 ± 0.78 [ h −1 Mpc]) than for a subsample with mean L TIR = 10 11.84 L ⨀ at z med ∼ 1.1 ( r 0 = 5.86 ± 0.69 h −1 Mpc). We find that galaxies at z med ∼ 0.9 can be ancestors of present day L ∗ early type galaxies, which exhibit a very high r 0 ∼ 8 h −1 Mpc.
How to make the top ten: Approximating PageRank from in-degree

PageRank has become a key element in the success of search engines, allowing to rank the most important hits in the top screen of results. One key aspect that distinguishes PageRank from other prestige measures such as in-degree is its global nature. From the information provider perspective, this makes it difficult or impossible to predict how their pages will be ranked. Consequently a market has emerged for the optimization of search engine results. Here we study the accuracy with which PageRank can be approximated by in-degree, a local measure made freely available by search engines. Theoretical and empirical analyses lead to conclude that given the weak degree correlations in the Web link graph, the approximation can be relatively accurate, giving service and information providers an effective new marketing tool.
Endoplasmic reticulum stress-activated cell reprogramming in oncogenesis.

UNLABELLED Stress induced by the accumulation of unfolded proteins in the endoplasmic reticulum (ER) is observed in many human diseases, including cancers. Cellular adaptation to ER stress is mediated by the unfolded protein response (UPR), which aims at restoring ER homeostasis. The UPR has emerged as a major pathway in remodeling cancer gene expression, thereby either preventing cell transformation or providing an advantage to transformed cells. UPR sensors are highly regulated by the formation of dynamic protein scaffolds, leading to integrated reprogramming of the cells. Herein, we describe the regulatory mechanisms underlying UPR signaling upon cell intrinsic or extrinsic challenges, and how they engage cell transformation programs and/or provide advantages to cancer cells, leading to enhanced aggressiveness or chemoresistance. We discuss the emerging cross-talk between the UPR and related metabolic processes to ensure maintenance of protein homeostasis and its impact on cell transformation and tumor growth. SIGNIFICANCE ER stress signaling is dysregulated in many forms of cancer and contributes to tumor growth as a survival factor, in addition to modulating other disease-associated processes, including cell migration, cell transformation, and angiogenesis. Evidence for targeting the ER stress signaling pathway as an anticancer strategy is compelling, and novel agents that selectively inhibit the UPR have demonstrated preliminary evidence of preclinical efficacy with an acceptable safety profile.
WORKING PAPER SERIES

ANALYZING THE PRODUCTIVITY-WAGE-UNEMPLOYMENT NEXUS IN MALAYSIA: EVIDEDENCE FROM THE MACROECONOMIC PERPECTIVE Using multivariate cointegration and error-correction modeling techniques, this paper attempts to examine whether there exists a productivity-wage-unemployment relationship in Malaysia at the macroeconomic level. The main findings show that unemployment is dichotomized from the long-run equilibrium relationship between labor productivity and real wages, implying labor productivity is an important long-run factor in determining real wages, while unemployment has a negligible effect on the real wage rates. However, real wages are very responsive to a change in labor productivity, signaling a tight labor market that leads to an increase in unit labor cost. To be more resilient to rising wages and productivity gaps in a globally competitive environment, Malaysian industries should move up the value chain, and promote skill-and technology-intensive production. JEL CLASSIFICATION CODES: J39
Cerebrospinal fluid metabolite and nigrostriatal dopaminergic function in Parkinson’s disease

Ishibashi K, Kanemaru K, Saito Y, Murayama S, Oda K, Ishiwata K, Mizusawa H, Ishii K. Cerebrospinal fluid metabolite and nigrostriatal dopaminergic function in Parkinson’s disease. Acta Neurol Scand: 2010: 122: 46–51. © 2009 The Authors Journal compilation © 2009 Blackwell Munksgaard.
Intracellular energy status regulates activity in hypocretin/orexin neurones: a link between energy and behavioural states

Non‐technical summary A growing body of evidence has shown that energy status has a significant impact on the behavioural states in animals and that the availability of nutrients (energy state) in the brain may modulate animal behaviours. In this study, we report that the intracellular energy stores determine activity in a selective group of nerve cells (hypocretin‐containing neurones) in the brain. The unique energy state of hypocretin neurones correlates with behavioural states of animals, i.e. the energy level is low during sleep and high during wakefulness. These results suggest that hypocretin neurones may act as an ‘energy gauge’ in the brain, which integrates nutritional, energetic and behavioural signals critical for the survival of animals.
An Excursion into the Statistical Properties of Hedge Funds

This paper provides an overview of the most important statistical properties of individual hedge fund returns. We find that the net-of-fees monthly returns of the average individual hedge fund exhibit significant degrees of negative skewness, excess kurtosis, as well as positive first-order serial correlation. The correlations between hedge funds in the same strategy group are of the same order of magnitude as the correlations between funds in different strategy groups and relatively low. Only 10-20% of the variation in the average individual hedge fund’s returns can be explained by what happens in the US equity and bond markets. Compared to individual funds, portfolios of hedge funds tend to exhibit lower skewness, higher serial correlation and higher correlation with stocks and bonds. Movements in the US equity and bond markets still only explain 20-40% of the variation in hedge fund portfolios returns though. Finally, an equally-weighted portfolio of all funds in our sample offers a 2.76% higher mean return than the average fund of funds. This strongly suggests that the timing and fund picking activities of the average fund of funds are not rewarded by a higher return.
Combined effect of PCV10 and meningococcal C conjugate vaccination on meningitis mortality among children under five years of age in Brazil

ABSTRACT The 10-valent pneumococcal conjugate vaccine (PCV10) was introduced in the Brazilian National Immunization Program in March 2010, scheduled at 2, 4, and 6 months, with a booster at 12–15 months of age. The meningococcal C conjugate vaccine (MCC) was introduced in November 2010, scheduled at 3 and 5 months, with a booster dose at 12–15 months of age and no catch-up for older age groups. In this interrupted time-series analysis study, we used Brazilian mortality data from 2005 to 2015 for children under five years of age (excluding data from the state of Bahia) to assess the combined impact of these vaccines on the overall burden of meningitis mortality among children aged 0–23 months and 2–4 years, as defined using meningitis and meningococcemia specific International Classification of Diseases - tenth revision codes. Secular trends and seasonality were taken into account. We found significant reductions for both age groups relative to those observed for the comparison group of diseases, with immediate effects after the transition period (2010-2011) of 29.2% and 27.5% for children aged 0–23 months and 2–4 years, respectively. These immediate effects were sustained throughout the post-vaccination period (2012–2015). In total, 337 deaths were averted by the combined effect of both vaccines, 238 (95%CI 169-319) for children aged 0–23 months and 99 (95%CI 56–144) for those aged 2–4 years. These results add strong evidence in support of investments in these vaccines by low and middle-income countries.
A Neuro-Fuzzy Model for Software Cost Estimation

A novel neuro-fuzzy constructive cost model (COCOMO) for software estimation is proposed. The model carries some of the desirable features of the neuro-fuzzy approach, such as learning ability and good interpretability, while maintaining the merits of the COCOMO model. Unlike the standard neural network approach, this model is easily validated by experts and capable of generalization. In addition, it allows inputs to be continuous-rating values and linguistic values, therefore avoiding the problem of similar projects having different estimated costs. Also presented in this paper is a detailed learning algorithm. The validation, using industry project data, shows that the model greatly improves the estimation accuracy in comparison with the well-known COCOMO model.
The Emergence of Up and Down States in Cortical Networks

The cerebral cortex is continuously active in the absence of external stimuli. An example of this spontaneous activity is the voltage transition between an Up and a Down state, observed simultaneously at individual neurons. Since this phenomenon could be of critical importance for working memory and attention, its explanation could reveal some fundamental properties of cortical organization. To identify a possible scenario for the dynamics of Up–Down states, we analyze a reduced stochastic dynamical system that models an interconnected network of excitatory neurons with activity-dependent synaptic depression. The model reveals that when the total synaptic connection strength exceeds a certain threshold, the phase space of the dynamical system contains two attractors, interpreted as Up and Down states. In that case, synaptic noise causes transitions between the states. Moreover, an external stimulation producing a depolarization increases the time spent in the Up state, as observed experimentally. We therefore propose that the existence of Up–Down states is a fundamental and inherent property of a noisy neural ensemble with sufficiently strong synaptic connections.