Miracle-dz/UniFAR-FTUs huggingface dataset:
EGFR-TKI and lung adenocarcinoma with CNS relapse: interest of molecular follow-up

The epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) erlotinib improves survival of lung cancer as second- or third-line therapy. However, after an initial response, most patients will recur, particularly within the central nervous system. The present study reports the case of a 27-yr-old nonsmoking male presenting with a metastatic lung adenocarcinoma with EGFR exon 19 deletion, associated with sensitivity to EGFR-TKI. Gefitinib, followed by chemotherapy and finally erlotinib resulted in prolonged disease control, until multiple liver metastases were detected. After stopping EGFR-TKI, brain metastases with carcinomatous meningitis were diagnosed. A secondary T790M mutation, associated with resistance to EGFR-TKI, was found on the liver biopsy but not in the cerebrospinal fluid. Erlotinib was reintroduced and allowed a quick neurological improvement, even though the extra-cranial disease remained resistant to erlotinib. The present report underscores the interest of molecular monitoring in lung cancer. Persistent cerebral tyrosine kinase inhibitor sensitivity should be considered in patients presenting with an early central nervous system relapse after stopping epidermal growth factor receptor tyrosine kinase inhibitor, even with a T790M-resistant mutation in noncerebral metastases. Questions remain concerning the selection of sub-clones during epidermal growth factor receptor tyrosine kinase inhibitor therapy, which could differ according to metastatic sites, especially in the central nervous system.
Understanding Undergraduate Students' Adoption of Mobile Learning Model: A Perspective of the Extended UTAUT2

Although mobile learning in higher education has recently received considerable attention, the fact remains that much of the scholarly effort has been limited to the notions of instrumentality. Drawing on UTAUT2 and extant literature on learning behavior, an adoption model that reflects the determinants of undergraduate students’ mobile learning acceptance in a consumer context was developed and empirically tested against data collected from 182 undergraduate students in China. Structural equation analysis results indicate that hedonic motivation, performance expectancy, social influence, and price value positively affect students’ mobile learning adoption. Surprisingly, self-management of learning was found to have both direct and indirect negative influences on undergraduate students’ adoption of mobile learning. Theoretical and practical implications of the findings are discussed.
A Multilinear Singular Value Decomposition

We discuss a multilinear generalization of the singular value decomposition. There is a strong analogy between several properties of the matrix and the higher-order tensor decomposition; uniqueness, link with the matrix eigenvalue decomposition, first-order perturbation effects, etc., are analyzed. We investigate how tensor symmetries affect the decomposition and propose a multilinear generalization of the symmetric eigenvalue decomposition for pair-wise symmetric tensors.
General Approach for Composite Thermoelectric Systems with Thermal Coupling: The Case of a Dual Thermoelectric Cooler

In this work, we show a general approach for inhomogeneous composite thermoelectric systems, and as an illustrative case, we consider a dual thermoelectric cooler. This composite cooler consists of two thermoelectric modules (TEMs) connected thermally in parallel and electrically in series. Each TEM has different thermoelectric (TE) properties, namely thermal conductance, electrical resistance and the Seebeck coefficient. The system is coupled by thermal conductances to heat reservoirs. The proposed approach consists of derivation of the dimensionless thermoelectric properties for the whole system. Thus, we obtain an equivalent figure of merit whose impact and meaning is discussed. We make use of dimensionless equations to study the impact of the thermal conductance matching on the cooling capacity and the coefficient of the performance of the system. The equivalent thermoelectric properties derived with our formalism include the external conductances and all intrinsic thermoelectric properties of each component of the system. Our proposed approach permits us changing the thermoelectric parameters of the TEMs and the working conditions of the composite system. Furthermore, our analysis shows the effect of the number of thermocouples on the system. These considerations are very useful for the design of thermoelectric composite systems. We reproduce the qualitative behavior of a commercial composite TEM connected electrically in series.
Author ' s personal copy Negative affectivity and EEG asymmetry interact to predict emotional interference on attention in early school-aged children

Negative affectivity (NA) is a broad construct that has been associated with the development of psychopathologies, such as anxiety, and with exaggerated attention to threatening stimuli. EEG asymmetry reflects biological individual differences in emotional reactivity that may underlie the association between NA and attention to threat. The present study included a sample of 31 five-seven year olds (M age in months = 74.39, SD = 6.57) to test the hypothesis that greater NA, combined with greater right anterior and posterior asymmetries, predicts increased attention interference following threat stimuli. Children completed an executive attention task which presented task-irrelevant threat (angry) and non-threat (neutral) faces prior to each trial. EEG asymmetry was measured at baseline for anterior, anterior-temporal and posterior scalp regions and child NA was measured via maternal report. As predicted, children showing greater NA and greater right anterior-temporal asymmetry showed more attention interference following angry faces. Additionally, two trend-level effects emerged: children showing greater NA and greater left anterior-temporal asymmetry showed less attention interference following angry faces, and children showing greater NA and greater left posterior asymmetry showed less attention interference, but only following neutral faces. Discussion focuses on the utility of using EEG asymmetry in the study of temperament, attentional biases, and the biological processes by which temperament confers risk for psychopathology. 2014 Elsevier Inc. All rights reserved.
Learning and Pricing with Models That Do Not Explicitly Incorporate Competition

In revenue management research and practice, demand models are used that describe how demand for a seller's products depends on the decisions, such as prices, of that seller. Even in settings where the demand for a seller's products also depends on decisions of other sellers, the models often do not explicitly account for such decisions. It has been conjectured in the revenue management literature that such monopoly models may incorporate the effects of competition, because the parameter estimates of the monopoly models are based on data collected in the presence of competition. In this paper we take a closer look at such a setting to investigate the behavior of parameter estimates and decisions if monopoly models are used in the presence of competition. We consider repeated pricing games in which two competing sellers use mathematical models to choose the prices of their products. Over the sequence of games, each seller attempts to estimate the values of the parameters of a demand model that expresses demand as a function only of its own price using data comprised only of its own past prices and demand realizations. We analyze the behavior of the sellers' parameter estimates and prices under various assumptions regarding the sellers' knowledge and estimation procedures, and we identify situations in which a the sellers' prices converge to the Nash equilibrium associated with knowledge of the correct demand model, b the sellers' prices converge to the cooperative solution, and c the sellers' prices have many potential limit points that are neither the Nash equilibrium nor the cooperative solution and that depend on the initial conditions. We compare the sellers' revenues at potential limit prices with their revenues at the Nash equilibrium and the cooperative solution, and we show that it is possible for sellers to be better off when using a monopoly model than at the Nash equilibrium.
Imagining what could happen: Effects of taking the role of a character on social cognition

In a series of experiments, Hakemulder (2000) showed that identifying with a story character representing a particular outgroup affects readers’ beliefs about that outgroup. The present contribution describes theories concerning the uses of imagining ourselves in the shoes of story characters. Second, it discusses the research concerning the fundamental processes that may underlie the effects of such imagination. And third, it presents the results of two experiments. The studies of Hakemulder (2000) were replicated, using a different story, examining the effects on not only university students (as in the previous studies) but also on high school students. Again it was shown that role-taking may be responsible for the effects of narratives on social cognition.
Leptin Administration Favors Muscle Mass Accretion by Decreasing FoxO3a and Increasing PGC-1α in ob/ob Mice

Absence of leptin has been associated with reduced skeletal muscle mass in leptin-deficient ob/ob mice. The aim of our study was to examine the effect of leptin on the catabolic and anabolic pathways regulating muscle mass. Gastrocnemius, extensor digitorum longus and soleus muscle mass as well as fiber size were significantly lower in ob/ob mice compared to wild type littermates, being significantly increased by leptin administration (P<0.001). This effect was associated with an inactivation of the muscle atrophy-related transcription factor forkhead box class O3 (FoxO3a) (P<0.05), and with a decrease in the protein expression levels of the E3 ubiquitin-ligases muscle atrophy F-box (MAFbx) (P<0.05) and muscle RING finger 1 (MuRF1) (P<0.05). Moreover, leptin increased (P<0.01) protein expression levels of peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α), a regulator of muscle fiber type, and decreased (P<0.05) myostatin protein, a negative regulator of muscle growth. Leptin administration also activated (P<0.01) the regulators of cell cycle progression proliferating cell nuclear antigen (PCNA) and cyclin D1, and increased (P<0.01) myofibrillar protein troponin T. The present study provides evidence that leptin treatment may increase muscle mass of ob/ob mice by inhibiting myofibrillar protein degradation as well as enhancing muscle cell proliferation.
Neutrino pair synchrotron radiation from relativistic electrons in strong magnetic fields

The emissivity for the neutrino pair synchrotron radiation in strong magnetic fields has been calculated both analytically and numerically for high densities and moderate temperatures, as can be found in neutron stars. Under these conditions, the electrons are relativistic and degenerate. We give here our results in terms of an universal function of a single variable. For two different regimes of the electron gas we present a simplified calculation and compare our results to those of Kaminker et al. Agreement is found for the classical region, where many Landau levels contribute to the emissivity , but some differences arise in the quantum regime. One finds that the emissivity for neutrino pair synchrotron radiation is competitive, and can be dominant, with other neutrino processes for magnetic fields of the order $B \sim 10^{14} - 10^{15} G $. This indicates the relevance of this process for some astrophysical scenarios, such as neutron stars and supernovae.
Characterization of Progressive Motor Deficits in Mice Transgenic for the Human Huntington’s Disease Mutation

Transgenic mice expressing exon 1 of the human Huntington’s disease (HD) gene carrying a 141–157 CAG repeat (line R6/2) develop a progressive neurological phenotype with motor symptoms resembling those seen in HD. We have characterized the motor deficits in R6/2 mice using a battery of behavioral tests selected to measure motor aspects of swimming, fore- and hindlimb coordination, balance, and sensorimotor gating [swimming tank, rotarod, raised beam, fore- and hindpaw footprinting, and acoustic startle/prepulse inhibition (PPI)]. Behavioral testing was performed on female hemizygotic R6/2 transgenic mice (n = 9) and female wild-type littermates (n = 22) between 5 and 14 weeks of age. Transgenic mice did not show an overt behavioral phenotype until around 8 weeks of age. However, as early as 5–6 weeks of age they had significant difficulty swimming, traversing the narrowest square (5 mm) raised beam, and maintaining balance on the rotarod at rotation speeds of 33–44 rpm. Furthermore, they showed significant impairment in prepulse inhibition (an impairment also seen in patients with HD). Between 8 and 15 weeks, R6/2 transgenic mice showed a progressive deterioration in performance on all of the motor tests. Thus R6/2 mice show measurable deficits in motor behavior that begin subtly and increase progressively until death. Our data support the use of R6/2 mice as a model of HD and indicate that they may be useful for evaluating therapeutic strategies for HD, particularly those aimed at reducing the severity of motor symptoms or slowing the course of the disease.
Impact on the Performance of Health Workers Adopted Performance-Related Contracts in the Provision of Basic Public Health Service At Village and Township Levels

Background This paper focus on the impact on the performance of health workers at village and township levels in the provision of a government stipulated package of basic public health service, which adopted the performance-related contracts mode. Methods: The concept of balanced scorecard was adopted and developed to gather the 11 evaluation indicators distributed in four quadrants. These were implemented using on-site questionnaire and interview design. Four thousand and twenty-one respondents at 30 administrative villages including 2674 respondents at 20 pilot villages and 1347 at 10 control villages were investigated. Meanwhile, 62 administration officials from three counties and nine townships were interviewed. Results: Eight of 11 evaluation indicators were obviously better in pilot counties than in Control County, The remaining three indicators respectively represented that equal, inferior to control county, and could not clear judge. Conclusion: The performance of health workers at village and township levels in the provision of basic public health service in pilot counties, which adopted the performance-related contracts mode, is better than before and control county.
Characterization of the CD4+ T Cell Response to Epstein-Barr Virus during Primary and Persistent Infection

The CD8+ T cell response to Epstein-Barr virus (EBV) is well characterized. Much less is known about the evolution of the CD4+ T cell response. Here we show that EBV stimulates a primary burst of effector CD4+ T cells and this is followed by a period of down-regulation. A small population of EBV-specific effector CD4+ T cells survives during the lifelong persistent phase of infection. The EBV-specific effector CD4+ T cells accumulate within a CD27+ CD28+ differentiation compartment during primary infection and remain enriched within this compartment throughout the persistent phase of infection. Analysis of CD4+ T cell responses to individual epitopes from EBV latent and lytic cycle proteins confirms the observation that the majority of the effector cells express both CD27 and CD28, although CD4+ T cells specific for lytic cycle antigens have a greater tendency to express CD45RA than those specific for the latent antigens. In clear contrast, effector CD4+ T cells specific for cytomegalovirus (CMV) accumulate within the CD27− CD28+ and CD27− CD28− compartments. There are striking parallels in terms of the differentiation of CD8+ T cells specific for EBV and CMV. The results challenge current ideas on the definition of memory subsets.
intermittent fasting vs continuous caloric restriction for weight and body composition changes in humans

Background: Obesity and overweight are major health concerns in the UK and worldwide. Dietary restriction is an effective strategy for weight and fat loss and it is mainly implemented as daily Calorie Restriction (CR). However, continuous CR has consistently shown to be difficult to adhere. Intermittent Fasting (IF) protocols have been recently proposed as an alternative for traditional CR where compliance might be improved since caloric restriction is only required during certain times or days of the week, rather than every day. Even though both approaches are proven to be effective, it remains unknown which one produces greater changes in body weight and body composition. Participants and Methods: Subjects (n = 14) were physically active, healthy non-obese (BMI < 29.9 kg/m2) males (n=4) and females (n=10) aged 20-30 that were randomly assigned to 5-week intervention programs that used either an Intermittent Fasting (IF) protocol of per iodised severe energy restriction (500 kcal/day for 2 days/week) or a traditional Calorie Restricted (CR) protocol (1200 kcal/day for 7 days/week). Body weight and body composition were assessed at baseline and at the end of the intervention. Results: Participants in the IF protocol lost significantly more weight than did CR participants at the end of the 5-week pro gram (0.8 ± 0.4 Kg versus 0.1 ± 0.6 Kg). Similarly, IF participants experienced significantly greater body fat reduction than did CR participants (1 ± 0.6 % versus 0.3 ± 0.7 %). However, even though participants did not report problems following the diet, researchers believe that subjects undergoing the CR intervention might have experienced adherence issues and could have unintentionally underestimated total food intake based on the results. Conclusion: The IF dietary approach has achieved significant weight loss and body composition improvements, whereas the CR approach has not produced any significant changes in weight or body composition. Moreover, it is believed that the CR protocol has led to adherence problems. continuous Restriction for changes in
Reference-based Variational Autoencoders

Learning disentangled representations from visual data, where different high-level generative factors are independently encoded, is of importance for many computer vision tasks. Solving this problem, however, typically requires to explicitly label all the factors of interest in training images. To alleviate the annotation cost, we introduce a learning setting which we refer to as reference-based disentangling. Given a pool of unlabelled images, the goal is to learn a representation where a set of target factors are disentangled from others. The only supervision comes from an auxiliary reference set containing images where the factors of interest are constant. To address this problem, we propose reference-based variational autoencoders, a novel deep generative model designed to exploit the weak-supervision provided by the reference set. By addressing tasks such as feature learning, conditional image generation or attribute transfer, we validate the ability of the proposed model to learn disentangled representations from this minimal form of supervision.
Numerical Orientation Workspace Analysis with Different Parameterization Methods

For numerical orientation workspace analysis, a finite partition of the orientation workspace in its parametric domain is necessary. Among various parameterization methods for rigid-body rotations, it has been realized that the Euler angles, the tilting-and-torsion (T&T) angles, and the exponential coordinates are appropriate for finite partition. With these three parameterization methods, the rigid body rotation group, i.e., the special orthogonal group (SO(3)), can be mapped to a rectangular parallel-piped (for Euler angles), a solid cylinder (for T&T angles), and a solid sphere (for exponential coordinates). To simplify the computation, isotropic/equi-volumetric partition schemes are proposed for the three geometric entities so that each of them can be geometrically divided into finite elements with equal volumes. As a result of parameterizations, the volume of orientation workspace, i.e., the volume of SO(3), can be numerically computed as a weighted volume sum of its constituent equi-volumetric elements in which the weightages are the element associated integration measures. Using such partition schemes, various global performance measures can be readily implemented so as to evaluate the quality of the orientation workspace. A comparison study for the three parameterization methods has shown that the exponential coordinates method is more effective for numerical orientation workspace analysis because it has no formulation singularity and exhibits higher computation accuracy
LC-VCO Design Optimization Methodology Based on the  $g_m/I_D$ Ratio for Nanometer CMOS Technologies

In this paper, an LC voltage-controlled oscillator (LC VCO) design optimization methodology based on the gm/ID tech nique and on the exploration of all inversion regions of the MOS transistor (MOST) is presented. An in-depth study of the com promises between phase noise and current consumption permits optimization of the design for given specifications. Semiempirical models of MOSTs and inductors, obtained by simulation, jointly with analytical phase noise models, allow to get a design space map where the design tradeoffs are easily identified. Four LC-VCO designs in different inversion regions in a 90-nm CMOS process are obtained with the proposed methodology and verified with electrical simulations. Finally, the implementation and measurements are presented for a 2.4-GHz VCO operating in moderate inversion. The designed VCO draws 440 μA from a 1.2-V power supply and presents a phase noise of -106.2 dBc/Hz at 400 kHz from the carrier.
Study of waves and structures at the boundaries of magnetospheres

Plasma exists in abundance throughout the universe and governs a large number of astrophysical processes that have been observed and are of interest. Studying the interactions of plasma with magnetic field waves, magnetic dipoles and counter-streaming plasma flows can provide insight in the fundamental physics that govern the universe and its evolution. In order to study these phenomena in-situ, we are limited to spacecraft measurements in the heliosphere. Planetary missions are the ones that provide the largest quantities of measurements of the same phenomenon, due to their orbital parameters. On the other hand, the cost of these missions, generally limits them to a single spacecraft with the exception of spacecraft that orbit the Earth. This thesis is mainly concerned with the study of the interactions of plasma at the boundary of magnetic dipoles and the electromagnetic waves that are present in such environments. Upstream of the boundary between the Earth’s magnetic field and the interplanetary magnetic field, the magnetopause (average distance from Earth ∼ 10RE ∼ 63000 km), a region of plasma heated by the bow shock exists, the magnetosheath. This region is rich in electromagnetic emissions and magnetic structures. The physical processes at the bow shock can provide insight in astrophysical phenomena. The interaction of the waves in the magnetosheath with the surrounding plasma is also of great interest as they govern the behaviour of the plasma. Specifically this thesis initially examines the physical processes at the bow shocks of Earth and Venus. The magnetic environments of the two planets are different, as Venus does not have a magnetic field generated by the rotation of its core, unlike Earth. This means that there is benefit in studying both under the same framework in order to determine the underlying physics. The work then continuous with the examination of electromagnetic emissions downstream of the Earth’s bow shock. These waves have been named lion roars and their exact origin is unclear, although they have been shown to change the properties of the plasma they interact with.