Miracle-dz/UniFAR-FTUs huggingface dataset:
The older the better: are elderly study participants more non-representative? A cross-sectional analysis of clinical trial and observational study samples

Objective Study participants can differ from the target population they are taken to represent. We sought to investigate whether older age magnifies such differences, examining age-trends, among study participants, in self-rated level of activity compared to others of the same age. Design Cross-sectional examination of the relation of participant age to reported ‘relative activity’ (ie, compared to others of the same age), a bidirectionally correlated proxy for relative vitality, in exemplars of randomised and observational studies. Setting University of California, San Diego (UCSD) Participants 2404 adults aged 40–79 including employees of UCSD, and their partners (San Diego Population Study, observational study). 1016 adults (aged 20-85) not on lipid medications and without known heart disease, diabetes, cancer or HIV (UCSD Statin Study, randomised trial). Measurements Self-rated activity relative to others’ age, 5-point Likert Scale, was evaluated by age decade, and related via correlation and regression to a suite of health-relevant subjective and objective outcomes. Results Successively older participants reported successively greater activity relative to others of their age (greater departure from the norm for their age), p<0.001 in both studies. Relative activity significantly predicted (in regression adjusted for age) actual activity (times/week exercised), and numerous self-rated and objective health-predictors. These included general self-rated health, CES-D (depression score), sleep, tiredness, energy; body mass index, waist circumference, serum glucose, high-density lipoprotein-cholesterol, triglycerides and white cell count. Indeed, some health-predictor associations with age in participants were ‘paradoxical,’ consistent with greater apparent health in older age—for study participants. Conclusions Study participants may not be representative of the population they are intended to reflect. Our results suggest that departures from representativeness may be amplified with increasing age. Consequently, the older the age, the greater the disparity may be between what is recommended based on ‘evidence, ’ and what is best for the patient. Trial Registration UCSD Statin Study—Clinicaltrials.gov # NCT00330980 (http://ClinicalTrials.gov)
Forecasting Pacific SSTs: Linear Inverse Model Predictions of the PDO

Abstract A linear inverse model (LIM) is used to predict Pacific (30°S–60°N) sea surface temperature anomalies (SSTAs), including the Pacific decadal oscillation (PDO). The LIM is derived from the observed simultaneous and lagged covariance statistics of 3-month running mean Pacific SSTA for the years 1951–2000. The model forecasts exhibit significant skill over much of the Pacific for two to three seasons in advance and up to a year in some locations, particulary for forecasts initialized in winter. The predicted and observed PDO are significantly correlated at leads of up to four seasons, for example, the correlation exceeds 0.6 for 12-month forecasts initialized in January–March (JFM). The LIM-based PDO forecasts are more skillful than persistence or a first-order autoregressive model, and have comparable skill to LIM forecasts of El Nino SSTAs. Filtering the data indicates that much of the PDO forecast skill is due to ENSO teleconnections and the global trend. Within LIM, SST anomalies can grow due to.
Characterization of soft-tissue response to mechanical loading using nuclear magnetic resonance (NMR) and functional magnetic resonance imaging (fMRI) of neuronal activity during sustained cognitive-stimulus paradigms

Research applications of nuclear magnetic resonance (NMR) span a broad range of fields and disciplines. The work presented in this dissertation attests to this fact. Specifically, the research topics discussed in the body of this work employ NMR spectroscopy and imaging to characterize the water diffusion and NMR relaxation times ex vivo in rabbit Achilles tendon and, in a clinical setting, employ functional magnetic resonance imaging (fMRI) to investigate the behavior of different neural networks over a period of sustained activity. In the ex vivo in rabbit Achilles tendon work, a series of studies were performed. First, the diffusion-time dependence of the water apparent diffusion coefficient (ADC) was characterized in a spectroscopic mode with the samples subjected to different states of tensile loading. The results of this study demonstrated: (1) the anisotropy of the diffusion of water through tendon; (2) the ADC is diffusion-time dependent; (3) the values of the ADC(tdif) curve increased with tensile loading; (4) a change at the short diffusion-time points that is consistent with the interpretation of a load-induced increase in the collagen fibril packing density; and (5) an increase in the water ADC at long diffusion times, hypothesized to be due to T1 editing. To further investigate these issues, another series of ex vivo in rabbit Achilles tendon experiments was performed that employed NMR imaging to spatially characterize the water ADC, T1 and T2 relaxation time constants. As with the spectroscopic work, these studies were also conducted with the tendon samples subjected to different states of tensile loading. The results from these imaging experiments demonstrated: (1) two regions with distinct differences in signal intensity across the tendon: a thin region of
Recyclable amitraz-ethylene vinyl acetate strips used for beehives treatment against Varroa destructor

In this work, a new recyclable ethylene-vinyl acetate (EVA)-based strip impregnated with amitraz (AMZ) was prepared, characterized, and evaluated for the treatment of Apis mellifera against Varroa destructor. Bees are important for natural pollination, honey, and related goods production. Varroa destructor is currently considered one of the major pests and important efforts around the world are focused on methods for varroasis treatment. The procedure of strips preparation presented in this work consisted of two steps: impregnation and molding of impregnated pellets. Differential scanning calorimetry and gas chromatography–mass spectrometry analyses confirmed that AMZ molecule resisted the impregnation and molding conditions. The strips were sufficiently strong to resist destruction by the bees. The final infestation was lower in the hives treated with AMZ/EVA strips than in those treated with commercial strips. In order to check the possibility of recycling, strips were cut into little pieces and were subjected to total AMZ extraction. Finally, the fragments were exposed to re-impregnation and molding. The strips prepared after the recycling process presented the same shape and AMZ load than fresh strips.
Characterization of leakage current of a post station insulator covered with ice with various surface conductivities

This research deals with the characterization of the time evolution of the leakage current (LC) during wet-grown ice accumulation on a porcelain station insulator. The results obtained demonstrated the influence of conductivity of applied water used for ice formation on the time evolution of the computed LC envelope. It was found that the influence of applied water conductivity is more significant after the icicles have completely bridged the insulator shed spacing than during their growth. During the formation of the ice bridge, erratic fluctuations in the LC envelope were observed which increased in intensity with increasing applied water conductivity. This was clearly identified by using the mean value of the empirical crossing spectrum (ECS) related to each LC envelope. In the same way, it was also demonstrated that the influence of applied water conductivity can be characterized by the cumulative energy of LC which can also be useful to identify the moment of shed spacing icicle bridging.
Thermodynamics of a black hole in a cavity

We present a unified thermodynamic description of configurations consisting of self-gravitating radiation with or without a black hole. We compute the thermal fluctuations and evaluate where they will induce a transition from metastable configurations towards stable ones. We show that the probability of finding such a transition is exponentially small. This indicates that, in a sequence of quasi-equilibrium configurations, the system will remain in metastable states until it approaches very closely the critical point beyond which no metastable configuration exists. Near that point, we relate the divergence of local temperature fluctuations to the approach of instability of the whole system, thereby generalizing the usual fluctuation analysis to cases where long-range forces are present. When angular momentum is added to the cavity, the above picture is slightly modified. Nevertheless, at high angular momentum, the black hole loses most of its mass before it reaches the critical point at which it evaporates completely.
Efficient Link Capacity and QoS Design for Network-on-Chip

This paper addresses the allocation of link capacities in the automated design process of a network-on-chip based system. Communication resource costs are minimized under quality-of-service timing constraints. First, we introduce a novel analytical delay model for virtual channeled wormhole networks with non-uniform link capacities that eliminates costly simulations at the inner-loop of the optimization process. Second, we present an efficient capacity allocation algorithm that assigns link capacities such that packet delays requirements for each flow are satisfied. We demonstrate the benefit of capacity allocation for a typical system on chip, where the traffic is heterogeneous and delay requirements may largely vary, in comparison with the standard approach which assumes uniform-capacity links
Player Rating Systems for Balancing Human Computation Games: Testing the Effect of Bipartiteness

Human Computation Games (HCGs) aim to engage volunteers to solve information tasks, yet suffer from low sustained engagement themselves. One potential reason for this is limited difficulty balance, as tasks difficulty is unknown and they cannot be freely changed. In this paper, we introduce the use of player rating systems for selecting and sequencing tasks as an approach to difficulty balancing in HCGs and game genres facing similar challenges. We identify the bipartite structure of user-task graphs as a potential issue of our approach: users never directly match users, tasks never match tasks. We therefore test how well common rating systems predict outcomes in bipartite versus non-bipartite chess data sets and log data of the HCG Paradox. Results indicate that bipartiteness does not negatively impact prediction accuracy: common rating systems outperform baseline predictions in HCG data, supporting our approach’s viability. We outline limitations of our approach and future work.
Immediacy and certainty: factors in understanding future reference

ABSTRACT Seventy-five children, 3, 4, and 5 years old, were interviewed about: (a) toys they had played with just a few minutes earlier, (b) toys they had played with on the preceding day, (c) toys they would play with in a few minutes, and (d) toys reserved for use on the following day. Verb forms indicating past and future time were used as well as the adverbials before and after. The past verb form was understood equally well in reference to the immediate past and the more remote past. However, the future verb form was better understood in reference to the immediate future than in reference to the remote future (the following day). The difference is discussed in terms of the intersection of time and mood in future verb forms. Immediacy of action and certainty of occurrence are suggested as early meaning components of future verb forms.
Mitochondrial PCR-based malaria detection in saliva and urine of symptomatic patients.

BACKGROUND Malaria can be diagnosed in saliva and urine using mitochondrial PCR detection of Plasmodium DNA. METHODS Blood, saliva and urine were collected from 99 febrile patients referred to health centers in Sistan and Baluchestan Province, southeastern Iran, from May to November 2011. The mitochondrial cytochrome b gene of Plasmodium falciparum and Plasmodium vivax was targeted in saliva, urine and blood samples using nested PCR. RESULTS Nested PCR proved to be more sensitive than microscopy for the diagnosis of sub-microscopic and mixed-species infections. The results of nested PCR amplifications of saliva and urine samples showed the same specificity of 97% and sensitivity of 91% and 70%, respectively. Nested PCR amplifications of saliva samples and microscopy showed the greatest area under the receiver operating characteristic (ROC) curve and were more accurate than nested PCR amplifications of urine samples. CONCLUSION Nested PCR amplification of saliva samples showed good levels of detection of mitochondrial Plasmodium DNA as compared to nested PCR of blood (к=0.84; AUC=0.94), which was used as a reference standard. Based on the results of nested PCR as well as the advantages of saliva sampling, we suggest that saliva could be an alternative to blood, in malaria diagnosis, in cases where repeat sampling is required. Further studies are needed to validate these findings.
A Comparative Study on the Inhibitory Effects of Different Parts and Chemical Constituents of Pomegranate on α‐Amylase and α‐Glucosidase

Pomegranate has been documented for the management of diabetes in Unani and Chinese medicine. This study compared the effects of the extracts of different pomegranate parts, including juice, peels, seeds and flowers, on carbohydrate digestive enzymes (α‐amylase and α‐glucosidase) in vitro. The methanolic flower extract inhibited α‐amylase and α‐glucosidase, while the methanolic peel extract inhibited α‐glucosidase selectively. The most active flower extract was subjected to water‐ethyl acetate partition. The ethyl acetate fraction was more potent than the water fraction in inhibiting both enzymes. Gallic acid and ellagic acid also showed selective inhibition against α‐glucosidase, and their presence in the ethyl acetate fraction was confirmed by HPLC‐DAD and HPLC‐HESI‐MS. Our findings suggest that the inhibition of carbohydrate digestive enzymes and their phenolic content may contribute to the anti‐hyperglycaemic effects of pomegranate flower and peel, and support their claims in diabetes. Copyright © 2012 John Wiley & Sons, Ltd.
Gene expression networks underlying retinoic acid-induced differentiation of human retinoblastoma cells.

PURPOSE To understand the genetic regulatory pathways underlying the retinoic acid (RA) induction of cone arrestin, gene array technology and other molecular tools were used to profile global gene expression changes in human retinoblastoma cells. METHODS Weri-Rb-1 retinoblastoma cells were cultured in the absence or presence of RA for various periods. DNA microarray analysis profiled gene expression followed by real-time PCR and Northern and immunoblot analyses to confirm the change in expression of selected retinal genes and their gene products. Additional methodology included flow cytometry analysis, immunocytochemistry, and terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL) assay. RESULTS DNA microarray analysis of approximately 6800 genes revealed RA-induced upregulation of cone-specific genes and downregulation of rod-specific genes in Weri-Rb-1 cells. Other significantly upregulated mRNAs included chicken ovalbumin upstream promoter-transcription factor (COUP-TF1), retinoid X receptor (RXR)-gamma, thyroid hormone receptor (TR)-beta2, and guanylyl cyclase-activating protein (GCAP)-1. Real-time PCR and/or Northern blot analysis confirmed the expression changes of a subset of genes including the upregulation of a pineal- and retina-specific transcription factor, CRX. RA treatment also led to G(0)/G(1) cell cycle arrest and increased both the intensity of human cone arrestin (hCAR)-immunoreactivity and the number of apoptotic cells. The cell-cycle-arrest stage correlated with the observed microarray results in which the RA treatment downregulated critical genes such as cyclins (cyclin E, cyclin D3) and cyclin-dependent kinases (CDK5, CDK10). CONCLUSIONS These data suggest that RA induces a subpopulation of retinoblastoma cells to differentiate toward a cone cell lineage while selectively leading other cells into apoptosis.
Nutritional and Health Beneﬁts of Inulin and Oligofructose Effects of Inulin on Lipid Parameters in Humans 1

Convincing lipid-lowering effects of the fructooligosaccharide inulin have been demonstrated in animals, yet attempts to reproduce similar effects in humans have generated conﬂicting results. This may be because of the much lower doses used in humans as a result of the adverse gastrointestinal symptoms exhibited by most subjects consuming daily doses in excess of 30 g. Two studies that fed either oligofructose (20 g/d) or inulin (14 g/d) observed no effect on fasting total, LDL or HDL cholesterol, or serum triglycerides. Two other studies that fed inulin either in a breakfast cereal (9 g/d) or as a powdered addition to beverages and meals (10 g/d) reported similar reductions in fasting triglycerides ( (cid:50) 27 and (cid:50) 19%, respectively). In one of these studies, total and LDL cholesterol concentrations were also modestly reduced (5 and 7%, respectively). Because animal studies have identiﬁed inhibition of hepatic fatty acid synthesis as the major site of action for the triglyceride-lowering effects of inulin, and because this pathway is relatively inactive in humans unless a high carbohydrate diet is fed, future attempts to demonstrate lipid-lowering effects of inulin should consider the nature of the background diet as a determinant of response. J. Nutr. 129: 1471S–1473S, 1999.
Assessment of dietary intake among university students: 24-hour recall verses weighed record method.

The purpose of this study was to assess the dietary intake of University Putra Malaysia students using the weighed record method and the 24 hour-dietary recall method. The validity of the 24-hour recall method was studied by comparing it with the weighed record method. A total of 40 male and 25 female students age between 18-29 years volunteered to participate in this study. All the subjects were required to weigh and record the foods they ate for 1 day. Without prior knowledge of the purpose of the visit , the 24-hour recall was carried out the following day. The nutrients analysed were calorie, carbohydrates, protein, fat, calcium, iron, vitamin A and vitamin C. Comparisons of the nutrient intake between these two methods were determined. The paired t-test indicated no significant difference in group's mean nutrient intake between the weighed record method for all nutrients. The differences in group mean intake for all nutrients between weighed record and 24-hour recall method ranged from -3% to 3.6%. A total of 4 nutrients were underestimated, namely energy, protein, vitamin C and iron. The correlation coefficients showed a strong positive relationships between the two methods (ranged from r = 0.88-0.98, p < 0.01) for all of the nutrients analysed. In conclusion, the agreement between nutrient values from two different methods indicated that the 24 hour recall is a suitable method for the dietary assessment of university students.
Toward human-like walking pattern generator

In this paper, we generate the biped gait of a humanoid robot that looks like a human's one. To generate the human like motion, we first capture walking motion of a human. Then, we analyze the captured data and obtain several information such as the relationship between the step length and waist height etc. We consider applying these informations to the real humanoid robot. Also, when the human walks, the sway of the waist is smaller than most of the humanoid robot's one. By compensating the angular momentum of the robot and by modifying the ZMP trajectory, we show that sway of the robot's waist can be smaller. We show the effectiveness of the proposed method through simulation and experimental results.
Disaster Metrics: A Proposed Quantitative Model for Benchmarking Prehospital Medical Response in Trauma-Related Multiple Casualty Events

Abstract Introduction Quantitative benchmarking of trauma-related prehospital response for Multiple Casualty Events (MCE) is complicated by major difficulties due to the simultaneous occurrences of multiple prehospital activities. Hypothesis/Problem Attempts to quantify the various components of prehospital medical response in MCE have fallen short of a comprehensive model. The objective of this study was to model the principal parameters necessary to quantitatively benchmark the prehospital medical response in trauma-related MCE. Methods A two-step approach was adopted for the methodology of this study: an extensive literature search was performed, followed by prehospital system quantitative modeling. Studies on prehospital medical response to trauma injuries were used as the framework for the proposed model. The North Atlantic Treaty Organization (NATO) triage categories (T1-T4) were used for the study. Results Two parameters, the Injury to Patient Contact Interval (IPCI) and Injury to Hospital Interval (IHI), were identified and proposed as the principal determinants of the medical prehospital response in trauma-related MCE. IHI is the time interval from the occurrence of injury to the completion of transfer of care of critical (T1) and moderate (T2) patients. The IHI for each casualty is compared to the Maximum Time Allowed described in the literature (golden hour for T1 and Friedrich's time for T2). In addition, the medical rescue factor (R) was identified as the overall indicator for the prehospital medical performance for T1 and T2, and a numerical value of one (R = 1) was proposed to be the quantitative benchmark. Conclusion A new quantitative model for benchmarking prehospital response to MCE in trauma-related MCE is proposed. Prospective studies of this model are needed to validate its applicability. Bayram J, Zuabi S. Disaster metrics: a proposed quantitative model for benchmarking prehospital medical response in trauma-related multiple casualty events. Prehosp Disaster Med. 2012;27(2):-7.