Miracle-dz/UniFAR-FTUs huggingface dataset:
Fitness test profiles in children aged 8-12 years old in Granada (Spain)

Fitness test profiles in children aged 8-12 years old in Granada (Spain). J. Hum. Sport Exerc. Vol. 6, No. 1, pp. 135-145, 2011. The aim of this study was to determine the effects of physical education in body composition and health-related fitness among boys and girls aged 8 to 12 years old in Granada (Spain) in a longitudinal, randomized study of 5 months. 106 children (49 boys and 57 girls) between 8 and 12 years old completed the study. They were healthy students of the public schools and no history of formal exercise training. Subjects were tested (body composition and health-related fitness, measured by EUROFIT) at baseline and at week 20. After 5 months of study, girls showed more fat mass than boys (p<0.05) and boys was more height than girls (p<0.05). Health-related fitness showed differences by gender only in slalom (boys vs. girls (p<0.05)). The results of body composition and health-related fitness revealed that the
Product Market Competition , Financial Accounting Misreporting and Corporate Governance : Evidence from Accounting Restatements *

Product market competition has a dual trait: while it serves as an efficient disciplinary mechanism for firms’ executives, it also exacerbates career concerns and heightens capital market pressures. We examine the effect of competition on financial accounting misreporting as manifested in earnings restatements. While on the one hand product market competition acts as a disciplinary mechanism in less competitive industries, on the other hand, it induces managers not to act in the best interest of shareholders in more competitive industries. These findings have implications for the design of corporate governance mechanisms and executive compensation contracts involving relative performance evaluation.
Optimal Control of Hybrid Electric Vehicles Based on Pontryagin's Minimum Principle

A number of strategies for the power management of hybrid electric vehicles (HEVs) are proposed in the literature. A key challenge is to achieve near-optimality while keeping the methodology simple. The Pontryagin's minimum principle (PMP) is suggested as a viable real-time strategy. In this brief, the global optimality of the principle under reasonable assumptions is described from a mathematical viewpoint. Instantaneous optimal control with an appropriate equivalent parameter for battery usage is shown to be possibly a global optimal solution under the assumption that the internal resistance and open-circuit voltage of a battery are independent of the state-of-charge (SOC). This brief also demonstrates that the optimality of the equivalent consumption minimization strategy (ECMS) results from the close relation of ECMS to the optimal-control-theoretic concept of PMP. In static simulation for a power-split hybrid vehicle, the fuel economy of the vehicle using the control algorithm proposed in this brief is found to be very close-typically within 1%-to the fuel economy through global optimal control that is based on dynamic programming (DP).
Hypoxia Induces Aortic Hypertrophic Growth, Left Ventricular Dysfunction, and Sympathetic Hyperinnervation of Peripheral Arteries in the Chick Embryo

Background—Low birth weight is associated with an increased incidence of cardiovascular diseases, including hypertension, later in life. This suggests that antenatal insults program for fetal adaptations of the circulatory system. In the present study, we evaluated the effects of mild hypoxia on cardiac function, blood pressure control, and arterial structure and function in near-term chick embryos. Methods and Results—Chick embryos were incubated under normoxic (21% O2) or hypoxic (15% O2) conditions and evaluated at incubation day 19 by use of histological techniques, isolated heart preparations, and in vivo measurements of sympathetic arterial tone and systemic hemodynamics. Chronic hypoxia caused a 33% increase in mortality and an 11% reduction in body weight in surviving embryos. The lumen of the ascending aorta in hypoxic embryos was 23% smaller. Left ventricular systolic pressure was 22% lower, and heart weight/body weight ratio was 14% higher. In resistance arteries of hypoxic embryos, in vivo baseline tone was 23% higher, norepinephrine sensitivity was similar, and norepinephrine release from sympathetic nerves increased 2-fold, indicating sympathetic hyperinnervation. Mean arterial pressure and heart rate were similar under resting conditions, but chronically hypoxic embryos failed to maintain blood pressure during acute stress. Conclusions—This study indicates that mild hypoxia during embryonic development induces alterations in cardiac and vascular function and structure and affects hemodynamic regulation. These findings reveal that antenatal insults have profound effects on the control and design of the circulatory system that are already established at birth and may program for hypertension and heart failure at a later age.
Cardioprotective interventions for cancer patients receiving anthracyclines.

BACKGROUND Anthracyclines are among the most effective chemotherapeutic agents in the treatment of numerous malignancies. Unfortunately, their use is limited by a dose-dependent cardiotoxicity. In an effort to prevent this cardiotoxicity, different cardioprotective agents have been studied. OBJECTIVES The objective of this review was to assess the efficacy of different cardioprotective agents in preventing heart damage in cancer patients treated with anthracyclines. SEARCH STRATEGY We searched the databases of the Cochrane Central Register of Controlled Trials (CENTRAL, Issue 2, 2007), MEDLINE (1966 to April 2007) and EMBASE (1980 to April 2007). In addition, we handsearched reference lists and conference proceedings of the SIOP and ASCO meetings (1998 to 2006). SELECTION CRITERIA Randomised controlled trials (RCTs) in which any cardioprotective agent was compared to no additional or placebo therapy in cancer patients (children and adults) receiving anthracyclines. DATA COLLECTION AND ANALYSIS Two review authors independently performed the study selection, quality assessment and data-extraction including adverse effects. MAIN RESULTS We identified RCTs for seven cardioprotective agents: N-acetylcysteine, phenetylamines, coenzyme Q10, combination of vitamins E and C and N-acetylcysteine, L-carnitine, carvedilol and dexrazoxane (mostly adults with advanced breast cancer). All studies had methodological limitations. For the first six agents, there were too few studies to allow pooling of results. None of the individual studies showed a cardioprotective effect. The nine included studies of dexrazoxane enrolled 1403 patients. The meta-analysis of dexrazoxane showed a statistically significant benefit in favour of dexrazoxane for the occurrence of heart failure (Relative Risk (RR) 0.29, 95% CI 0.20 to 0.41). No evidence was found for a difference in response rate or survival between the dexrazoxane and control group. Only for one adverse effect (abnormal white blood cell count at nadir) a difference in favour of the control group was identified. AUTHORS' CONCLUSIONS For cardioprotective agents for which pooling was impossible, no definitive conclusions can be made about their efficacy. Dexrazoxane prevents heart damage and no evidence for a difference in response rate or survival between the dexrazoxane and control group was identified. Only for an abnormal white blood cell count at nadir a clearly significant difference in favour of the control group was identified. We conclude that if the risk of cardiac damage is expected to be high, it might be justified to use dexrazoxane in patients with cancer treated with anthracyclines. However, for each individual patient clinicians should weigh the cardioprotective effect of dexrazoxane against the possible risk of adverse effects.
Energy Confinement and MHD Activity in Shaped TCV Plasmas with Localized Electron Cyclotron Heating

Confinement in TCV electron cyclotron heated discharges was studied as a function of plasma shape, i.e. as a function of elongation, 1.1 < kappa < 2.15, and triangularity, -0.65 less than or equal to delta less than or equal to 0.55. The electron energy confinement time was found to increase with elongation, owing in part to the increase of plasma current with elongation. The beneficial effect of negative triangularities was most effective at low power and tended to decrease at the higher powers used. The large variety of sawtooth types observed in TCV for different power deposition locations, from on-axis to the q = 1 region, was simulated with a model that included local power deposition, a growing m/n = 1 island (convection and reconnection), plasma rotation and finite heat diffusivity across flux surfaces. Furthermore, a model with local magnetic shear reproduced the experimental observation that the sawtooth period is at a maximum when the heating is close to the q = 1 surface.
Key Policy Issues in Entrepreneurship and Sme Development Fostering Entrepreneurship in Rural Areas

Part II of this report is structured in six thematic chapters. Each chapter starts with a summary of main findings from the local case study areas by the OECD. In the following paper, both theoretical and practical aspects of policy action are discussed in light of new policy approaches and options. References are made to good practice initiatives in East Germany and other regions in OECD member countries. A chapter concludes with the OECD policy recommendations presented as a 'Checklist'. Along with a selection of international learning models and good practice examples in East Germany, this final section of each thematic chapter aims to inspire policy innovation and the development of local approaches to strengthen entrepreneurship.
A comparative profile of the Internet gambler: Demographic characteristics, game-play patterns, and problem gambling status

Overcoming the methodological limitations of many previous studies, the present study employs a two-phased approach to data collection, and a weighted approach to data analysis, thereby obtaining survey data from 1954 Internet gamblers and 5967 non-Internet gamblers. Using this data, the authors examine: (1) the comparative demographic and health characteristics of Internet versus land-based gamblers; (2) the characteristics predictive of Internet gambling; (3) the game-play patterns of Internet gamblers; (4) the comparative gambling expenditures of Internet versus land-based gamblers; and (5) the comparative rate of problem gambling among Internet versus land-based gamblers. The article concludes with a discussion of the methodological implications the present study holds for future research. Moreover, in light of the key finding that Internet gamblers are three to four times more likely to have a gambling problem, the article concludes with a discussion of relevant theoretical and policy implications.
The FlowVizMenu and Parallel Scatterplot Matrix: Hybrid Multidimensional Visualizations for Network Exploration

A standard approach for visualizing multivariate networks is to use one or more multidimensional views (for example, scatterplots) for selecting nodes by various metrics, possibly coordinated with a node-link view of the network. In this paper, we present three novel approaches for achieving a tighter integration of these views through hybrid techniques for multidimensional visualization, graph selection and layout. First, we present the FlowVizMenu, a radial menu containing a scatterplot that can be popped up transiently and manipulated with rapid, fluid gestures to select and modify the axes of its scatterplot. Second, the FlowVizMenu can be used to steer an attribute-driven layout of the network, causing certain nodes of a node-link diagram to move toward their corresponding positions in a scatterplot while others can be positioned manually or by force-directed layout. Third, we describe a novel hybrid approach that combines a scatterplot matrix (SPLOM) and parallel coordinates called the Parallel Scatterplot Matrix (P-SPLOM), which can be used to visualize and select features within the network. We also describe a novel arrangement of scatterplots called the Scatterplot Staircase (SPLOS) that requires less space than a traditional scatterplot matrix. Initial user feedback is reported.
RunWithUs: a social sports application in the ubiquitous Oulu environment

Authorities recommend the practice of moderate physical activity to improve health and quality of life, but sometimes it is difficult to find the willpower or the motivation to reserve a few minutes to exercise. In this paper we describe a new tool designed to help users to practice sport and record their achievements, which makes the activity more social (finding friends, sharing results, etc.). Furthermore, this tool has been integrated in the "Ubiquitous Oulu", an intelligent city that provides the building blocks to bring it closer to citizens. In this real-life environment we had the opportunity to assess the technical viability of RunWithUs and to identify the main interests of its potential users.
The impact of whole-of-diet interventions on depression and anxiety: a systematic review of randomised controlled trials

Abstract Objective Non-pharmacological approaches to the treatment of depression and anxiety are of increasing importance, with emerging evidence supporting a role for lifestyle factors in the development of these disorders. Observational evidence supports a relationship between habitual diet quality and depression. Less is known about the causative effects of diet on mental health outcomes. Therefore a systematic review was undertaken of randomised controlled trials of dietary interventions that used depression and/or anxiety outcomes and sought to identify characteristics of programme success. Design A systematic search of the Cochrane, MEDLINE, EMBASE, CINAHL, PubMed and PyscInfo databases was conducted for articles published between April 1971 and May 2014. Results Of the 1274 articles identified, seventeen met eligibility criteria and were included. All reported depression outcomes and ten reported anxiety or total mood disturbance. Compared with a control condition, almost half (47 %) of the studies observed significant effects on depression scores in favour of the treatment group. The remaining studies reported a null effect. Effective dietary interventions were based on a single delivery mode, employed a dietitian and were less likely to recommend reducing red meat intake, select leaner meat products or follow a low-cholesterol diet. Conclusions Although there was a high level of heterogeneity, we found some evidence for dietary interventions improving depression outcomes. However, as only one trial specifically investigated the impact of a dietary intervention in individuals with clinical depression, appropriately powered trials that examine the effects of dietary improvement on mental health outcomes in those with clinical disorders are required.
Suppression of Proliferation and Invasive Behavior of Human Metastatic Breast Cancer Cells by Dietary Supplement BreastDefend

Aim: The study was to evaluate the effect of the dietary supplement BreastDefend (BD) on the proliferation and invasive behavior of highly metastatic human breast cancer cells in vitro. Methods: Cell proliferation and cytotoxicity of BD was evaluated in MDA-MB-231 cells treated with BD (0-40 μg/mL) by MTT assay and trypan blue staining, respectively. Expression of cell cycle regulatory genes were determined by DNA-microarray analysis. Effect of BD on invasiveness was assessed by cellular adhesion, migration, and invasion assays. Results: BD treatment of cells MDA-MB-231 resulted in the cytostatic inhibition of cell proliferation with IC50 22.2, 19.1, and 17.5 μg/mL for 24, 48, and 72 hours, respectively. The inhibition of proliferation was mediated by the upregulation expression of CCNG1, CHEK1, CDKN1C, GADD45A, and E2F2, whereas BD downregulated expression of CCNA1 and CDK6 genes. The induction of expression of GADD45A and inhibition of expression of cyclin A1 (gene CCNA1) by BD was also confirmed on the protein level. BD treatment suppressed the invasive behavior of MDA-MB-231 cells by the inhibition of cellular adhesion, migration, and invasion. This inhibition of invasiveness was mediated by the suppression of secretion of urokinase plasminogen activator (uPA), and by the downregulation of expression of CXCR4 in breast cancer cells treated with BD. Conclusion: BD inhibits proliferation and invasive behavior of the highly metastatic human breast cancer cells in vitro. BD may have a therapeutic potential for prevention or treatment of highly metastatic breast cancers.
Dynamic Mean-Variance Asset Allocation

Mean-variance criteria remain prevalent in multi-period problems, and yet not much is known about their dynamically optimal policies. We provide a fully analytical characterization of the optimal dynamic mean-variance portfolios within a general incomplete-market economy, and recover a simple structure that also inherits several conventional properties of static models. We also identify a probability measure that incorporates intertemporal hedging demands and facilitates much tractability in the explicit computation of portfolios. We solve the problem by explicitly recognizing the time-inconsistency of the mean-variance criterion and deriving a recursive representation for it, which makes dynamic programming applicable. We further show that our time-consistent solution is generically different from the pre-commitment solutions in the extant literature, which maximize the mean-variance criterion at an initial date and which the investor commits to follow despite incentives to deviate. We illustrate the usefulness of our analysis by explicitly computing dynamic mean-variance portfolios under various stochastic investment opportunities in a straightforward way, which does not involve solving a Hamilton-Jacobi-Bellman differential equation. A calibration exercise shows that the mean-variance hedging demands may comprise a significant fraction of the investor's total risky asset demand.
Natural stress relief meditation as a tool for reducing anxiety and increasing self-actualization

Natural Stress Relief (NSR) Meditation, a mental technique practiced for 15 minutes twice a day, reduces stress and anxiety by inducing a physiological state of deep rest. Regular practice of this technique appears to reduce trait anxiety and to develop qualities associated with self-actualization, such as inner peace, satisfaction, and creativity. This article reports new research that documents this effect using psychometric measures. A group of 31 practitioners showed, after four weeks of regular practice, a significant reduction of trait anxiety as measured by the State-Trait Anxiety Inventory (STAI; Spielberger, Gorsuch, Lushene, Vagg, & Jacobs, 1983) (effect size d = .69, calculated following Cohen), and a significant increase of self-actualization as measured by the Jones and Crandall (1986) Short Index of Self-Actualization (SISA; effect size d = .47).
Protease activated receptor-1 inhibits the Maspin tumor-suppressor gene to determine the melanoma metastatic phenotype

The thrombin receptor protease activated receptor-1 (PAR-1) is overexpressed in metastatic melanoma cell lines and tumor specimens. Previously, we demonstrated a significant reduction in tumor growth and experimental lung metastasis after PAR-1 silencing via systemic delivery of siRNA encapsulated into nanoliposomes. Gene expression profiling identified a 40-fold increase in expression of Maspin in PAR-1–silenced metastatic melanoma cell lines. Maspin promoter activity was significantly increased after PAR-1 silencing, suggesting that PAR1 negatively regulates Maspin at the transcriptional level. ChIP analyses revealed that PAR-1 decreases binding of Ets-1 and c-Jun transcription factors to the Maspin promoter, both known to activate Maspin transcription. PAR-1 silencing did not affect Ets-1 or c-Jun expression; rather it resulted in increased expression of the chromatin remodeling complex CBP/p300, as well as decreased activity of the CBP/p300 inhibitor p38, resulting in increased binding of Ets-1 and c-Jun to the Maspin promoter and higher Maspin expression. Functionally, Maspin expression reduced the invasive capability of melanoma cells after PAR-1 silencing, which was abrogated after rescuing with PAR-1. Furthermore, tumor growth and experimental lung metastasis was significantly decreased after expressing Maspin in a metastatic melanoma cell line. Moreover, silencing Maspin in PAR-1–silenced cells reverted the inhibition of tumor growth and experimental lung metastasis. Herein, we demonstrate a mechanism by which PAR-1 negatively regulates the expression of the Maspin tumor-suppressor gene in the acquisition of the metastatic melanoma phenotype, thus attributing an alternative function to PAR-1 other than coagulation.
Health Plan Disenrollment in a Choice-Based Medicaid Managed Care Program

Consumer decisions to switch health plans have implications for quality of care and risk selection. We examine factors related to time to disenrollment in a Medicaid managed care program where beneficiaries face a menu of plans and can change plans every month. Several findings have direct policy relevance. Families and individuals who make active choices upon entering the program are at substantially lower risk of disenrollment than those who are auto-assigned. Interactions between enrollee ethnicity and provider language proficiency suggest that enrollee satisfaction depends on the cultural competence of providers. Differential disenrollment by risk status results in adverse retention for certain types of plans.
Implementing and Evaluating Provers for First-order Modal Logics

While there is a broad literature on the theory of first-order modal logics, little is known about practical reasoning systems for them. This paper presents several implementations of fully automated theorem provers for first-order modal logics based on different proof calculi. Among these calculi are the standard sequent calculus, a prefixed tableau calculus, an embedding into simple type theory, an instance-based method, and a prefixed connection calculus. All implementations are tested and evaluated on the new QMLTP problem library for first-order modal logic.
Parvovirus B19 in HIV+ adult patients with different CD4+ lymphocyte counts.

PURPOSE Human parvovirus B19 (B19V) can cause anemia in immunocompromised patients. We aimed to investigate the presence of B19V in HIV+ adults with different CD4+ T cell counts, to recognise the frequency of B19V in these different conditions and its possible association with anemia. METHODOLOGY We studied B19V specific IgM, IgG and DNA in 98 HIV+ patients and in 52 healthy individuals. HIV load, CD4+ counts and haemoglobin level were also determined in the patients. RESULTS No individual in the control group had detectable IgM, 41/52 (78.8 %) had IgG and 5/52 (9.6 %) had B19V DNA. Among HIV+ patients, we found 5/98 (5.1 %) IgM+, 66/98 (67.3 %) IgG+ and 15/98 (15.3 %) had B19V DNA (no significant differences between the two groups compared). Considering the CD4+ cell range in HIV patients, 37 had <200 CD4+ cells ml-1, 31 had 200-500, and 30 had >500. Anti-B19V IgG prevalence in patients with >500 CD4+ cells ml-1 was significantly higher than in the rest (P=0.004) and compared to the control (P=0.046). B19V DNA concentration was always <103 IU ml-1, including 5 healthy individuals and 15 HIV+ patients. There was no significant association between B19V IgM or DNA and anemia nor between B19V DNA and HIV load. CONCLUSIONS The results indicate that B19V is not a high-risk factor for anemia in adult HIV+ patients under HAART treatment. Further studies will contribute to elucidate the mechanisms and significance of B19V DNA prevalence/persistence in adults, independently of the CD4+ cell status.