Miracle-dz/UniFAR-FTUs huggingface dataset:
Subcircuit-specific neuromodulation in the prefrontal cortex

During goal-directed behavior, the prefrontal cortex (PFC) exerts top-down control over numerous cortical and subcortical regions. PFC dysfunction has been linked to many disorders that involve deficits in cognitive performance, attention, motivation, and/or impulse control. A common theme among these disorders is that neuromodulation of the PFC is disrupted. Anatomically, the PFC is reciprocally connected with virtually all neuromodulatory centers. Recent studies of PFC neurons, both in vivo and ex vivo, have found that subpopulations of prefrontal projection neurons can be segregated into distinct subcircuits based on their long-range projection targets. These subpopulations differ in their connectivity, intrinsic properties, and responses to neuromodulators. In this review we outline the evidence for subcircuit-specific neuromodulation in the PFC, and describe some of the functional consequences of selective neuromodulation on behavioral states during goal-directed behavior.
Components of effective teacher induction programs and the impact of experienced mentors

Based on data from the 2007-08 Schools and Staffing Survey (SASS), 2008-09 Teacher Follow-up Survey (TFS) and 2009-10 Beginning Teacher Longitudinal Study (BTLS) datasets, this study examined a prediction model for new teacher retention that combined variables from both the presence of induction program components and mentoring traits. New teacher retention was selected as an important criterion because attrition causes a large financial burden on already budget-limited districts, and teacher turnover impacts teacher effectiveness and student learning. Results of a logistic regression analysis indicated that the presence of an induction program (W1T0220), the presence of a mentor (W2MNTYN), the use of seminars or classes for beginning teachers (W1T0223), and regular supportive communication with a principal or other administrator (W1T0225) during the first year of teaching were significant predictors for teacher retention in a sample of N = 1992 new teachers. Two-way frequencies revealed that new teachers who did not participate in an induction program left teaching in years two and three at nearly twice the rate of those who had induction. Similarly, teachers who had seminars or classes for beginning teachers and regular supportive communication with their principals, department chairs, or other administrators left teaching in years two and three at half the rate of those new teachers who did not have either of those induction components. Additionally, teachers who worked with a mentor during their first year of teaching left teaching in years two and three at half the rate of those teachers who did not have a mentor. Generalized induction programs utilizing each of the significant predictors are presented with the expectation that their use could decrease teacher attrition and result in greater overall teacher effectiveness and student learning. This dissertation is approved for Recommendation to the Graduate Council Dissertation Director: ____________________________________ Dr. Laura Kent Dissertation Committee: ____________________________________ Dr. Thomas Smith ____________________________________ Dr. Ronna Turner ____________________________________ Dr. Michael Wavering DISSERTATION DUPLICATION RELEASE I hereby authorize the University of Arkansas Libraries to duplicate this dissertation when needed for research and/or scholarship. Agreed ____________________________________________ Craig McBride Refused ____________________________________________ Craig McBride
Resorbability and solubility of zinc-containing tricalcium phosphate.

Using zinc-containing tricalcium phosphate (ZnTCP) as the zinc carrier for zinc-releasing calcium phosphate ceramic implants promoted bone formation around the implants. Because no quantitative information was available on the equilibrium solubility and resorbability of ZnTCP, in vitro equilibrium solubility and in vivo resorbability of ZnTCP were determined and compared quantitatively in this study. The solubility of ZnTCP decreased with increasing zinc content. The negative logarithm of the solubility product (K(sp)) of ZnTCP was expressed as pK(sp) = 28.686 + 1.7414C - 0.42239C(2) + 0.063911C(3) - 0.0051037C(4) + 0.0001595C(5) in air, where C is the zinc content in ZnTCP (mol %). The solubility of ZnTCP containing a nontoxic level of zinc (<0.63 wt %) decreased to 52-92% of the solubility of pure tricalcium phosphate (TCP) in the pH range 5.0-7.4. However, the in vivo resorbed volume of ZnTCP containing the same amount of zinc was much lower than that expected from the in vitro solubility, becoming as low as 26-20% of that of TCP. Cellular resorption of TCP is substantially a process of dissolution in a fluid with an acidic pH that is maintained by the activities of cells. Therefore, the reduction of the resorbability of ZnTCP could be attributable principally to its lowered cellular activation property relative to that associated with pure TCP.
Futsal Match-Related Fatigue Affects Running Performance and Neuromuscular Parameters but Not Finishing Kick Speed or Accuracy

Purpose: The aim of the present study was to investigate the influence of futsal match-related fatigue on running performance, neuromuscular variables, and finishing kick speed and accuracy. Methods: Ten professional futsal players participated in the study (age: 22.2 ± 2.5 years) and initially performed an incremental protocol to determine maximum oxygen uptake (V˙O2max: 50.6 ± 4.9 mL.kg−1.min−1). Next, simulated games were performed, in four periods of 10 min during which heart rate and blood lactate concentration were monitored. The entire games were video recorded for subsequent automatic tracking. Before and immediately after the simulated game, neuromuscular function was measured by maximal isometric force of knee extension, voluntary activation using twitch interpolation technique, and electromyographic activity. Before, at half time, and immediately after the simulated game, the athletes also performed a set of finishing kicks for ball speed and accuracy measurements. Results: Total distance covered (1st half: 1986.6 ± 74.4 m; 2nd half: 1856.0 ± 129.7 m, P = 0.00) and distance covered per minute (1st half: 103.2 ± 4.4 m.min−1; 2nd half: 96.4 ± 7.5 m.min−1, P = 0.00) demonstrated significant declines during the simulated game, as well as maximal isometric force of knee extension (Before: 840.2 ± 66.2 N; After: 751.6 ± 114.3 N, P = 0.04) and voluntary activation (Before: 85.9 ± 7.5%; After: 74.1 ± 12.3%, P = 0.04), however ball speed and accuracy during the finishing kicks were not significantly affected. Conclusion: Therefore, we conclude that despite the decline in running performance and neuromuscular variables presenting an important manifestation of central fatigue, this condition apparently does not affect the speed and accuracy of finishing kicks.
Effects of Inspiratory Muscle Training and Calisthenics-and-Breathing Exercises in COPD With and Without Respiratory Muscle Weakness

BACKGROUND: Patients with COPD may experience respiratory muscle weakness. Two therapeutic approaches to the respiratory muscles are inspiratory muscle training and calisthenics-and-breathing exercises. The aims of the study are to compare the effects of inspiratory muscle training and calisthenics-and-breathing exercises associated with physical training in subjects with COPD as an additional benefit of strength and endurance of the inspiratory muscles, thoracoabdominal mobility, physical exercise capacity, and reduction in dyspnea on exertion. In addition, these gains were compared between subjects with and without respiratory muscle weakness. METHODS: 25 subjects completed the study: 13 composed the inspiratory muscle training group, and 12 composed the calisthenics-and-breathing exercises group. Subjects were assessed before and after training by spirometry, measurements of respiratory muscle strength and test of inspiratory muscle endurance, thoracoabdominal excursion measurements, and the 6-min walk test. Moreover, scores for the Modified Medical Research Council dyspnea scale were reported. RESULTS: After intervention, there was a significant improvement in both groups of respiratory muscle strength and endurance, thoracoabdominal mobility, and walking distance in the 6-min walk test. Additionally, there was a decrease of dyspnea in the 6-min walk test peak. A difference was found between groups, with higher values of respiratory muscle strength and thoracoabdominal mobility and lower values of dyspnea in the 6-min walk test peak and the Modified Medical Research Council dyspnea scale in the inspiratory muscle training group. In the inspiratory muscle training group, subjects with respiratory muscle weakness had greater gains in inspiratory muscle strength and endurance. CONCLUSIONS: Both interventions increased exercise capacity and decreased dyspnea during physical effort. However, inspiratory muscle training was more effective in increasing inspiratory muscle strength and endurance, which could result in a decreased sensation of dyspnea. In addition, subjects with respiratory muscle weakness that performed inspiratory muscle training had higher gains in inspiratory muscle strength and endurance but not of dyspnea and submaximal exercise capacity. (ClinicalTrials.gov registration NCT01510041.)
Felicittà: Visualizing and Estimating Happiness in Italian Cities from Geotagged Tweets

Felicitta is an online platform for estimating happiness in the Italian cities, which uses Twitter as data source and combines sentiment analysis and visualization techniques in order to provide users with an interactive interface for data exploration. In particular, Felicitta daily analyzes Twitter posts and exploits temporal and geo-spatial information related to Tweets in order to easy the summarization of sentiment analysis outcomes and the exploration of the Twitter data. By interactive maps it provides users with the possibility to have a comprehensive overview of the sentiment analysis results about the main Italian cities, and with the opportunity to zoom-in to a specific region to visualize a fine-grained map of the city or district as well as the location of the individual sentiment-labeled Tweets. The platform allow users to tune their view on such huge amount of information and to interactively reduce the inherent complexity, possibly providing an hint for finding meaningful patterns, and correlations between moods and events.
High Efficacy of Clonal Growth and Expansion of Adult Neural Stem Cells

Neural stem cells (NSCs) from the adult central nervous system are currently being investigated for their potential use in autologous cell replacement strategies. High expansion rates of NSCs in culture are crucial for the generation of a sufficient amount of cells needed for transplantation. Here, we describe efficient growth of adult NSCs in Neurobasal medium containing B27 supplement under clonal and low-density conditions in the absence of serum or conditioned medium. Expansion of up to 15-fold within 1 week was achieved on low-density NSC cultures derived from the lateral ventricle wall, the hippocampal formation, and the spinal cord of adult rats. A 27% single-cell cloning efficiency in Neurobasal/B27 combination further demonstrates its growth-promoting ability. Multipotency and nontumorgenicity of NSCs were retained despite the high rate of culture expansion. In addition, increased cell survival was obtained when Accutase, instead of trypsin, was used for enzymatic dissociation of NSC cultures. This work provides an important step toward the development of standardized protocols for highly efficient in vitro expansion of NSCs from the adult central nervous system to move more closely to the clinical use of NSCs.
Echinacea and truth in labeling.

BACKGROUND Echinacea sales represent 10% of the dietary supplement market in the United States, but there is no guarantee as to the content, quality, variability, or contamination in Echinacea preparations. OBJECTIVE To qualitatively and quantitatively assess the contents of Echinacea-only preparations available in a retail setting. METHODS One of each single-herb Echinacea preparations that were available in August 2000 was obtained from several stores in the Denver, Colo, area. Thin-layer chromatography (TLC) was used to determine species and measure quantity. From this information, accuracy of species labeling and comparison of constituent to labeled content were assessed. The samples were stratified by whether they were labeled as standardized, and the standardized and nonstandardized samples were compared by ratio of constituent to labeled content. RESULTS Of the samples, 6 (10%) of 59 preparations contained no measurable Echinacea. The assayed species content was consistent with labeled content in 31 (52%) of the samples. Of the 21 standardized preparations, 9 (43%) met the quality standard described on the label. Labeled milligrams were weakly associated with measured constituent (r = 0.35; P =.02). CONCLUSIONS Echinacea from retail stores often does not contain the labeled species. A claim of "standardization" does not mean the preparation is accurately labeled, nor does it indicate less variability in concentration of constituents of the herb.
ATTEMPTED SUICIDE : QUALITATIVE STUDY OF ADOLESCENT FEMALES ’ LIVED EXPERIENCE

Background. Different aspects of adolescent suicidal behaviour are explored, however, they are interpreted in terms suitable mostly for adult suicidal behaviour. Knowledge on adolescent suicidality is far from comprehensive. Aims. To describe the lived experience of attempted suicide among young females and to unfold distinctiveness of such experience. Method. Three adolescent females aged 13 to 17, who attempted suicide within one year period while not in the state of psychosis, took part in the study. Research was conducted using interpretative phenomenological analysis – a qualitative research method which aims to explore both experience of a person and one’s trying to make sense of it. Data was collected during semi-structured interviews which allowed setting a closer contact with respondents. Results. Data analysis showed that though a fair amount of attempted suicide experiences of adolescent females is similar to those of adults, there are some distinct features: sense of overwhelming experience and amassing bothers, liveliness of past experiences in the present, great lack of support in close relationships, difficulties reflecting and controlling emotions and thoughts. Conclusions. These results support the huge importance of appropriate responses of the surrounding people and mental health care professionals to the state of suicidal adolescent female. Also, it is necessary to teach adolescent females to effectively manage their emotions and impulses, and to develop mature ego defense mechanisms. Further research could contribute to the creation of guidelines to such behaviour or training and a deeper understanding of the psychological state of suicidal adolescents.
Repeated Interactions and Contractual Detail: Identifying the Learning Effect

Organizations interacting repeatedly on similar transactions may learn from prior experiences, allowing contracts to be specified in greater detail. In this study, we analyze the conditions under which this learning effect is most likely to manifest itself. We do this by focusing on different parts of a contract as well as differences across transacting parties. Using a survey of information technology procurement contracts from 788 Dutch small- and medium-sized enterprises, we show that the learning effect is stronger for technical than for legal detail in contracts and is stronger for firms with information technology expertise than for firms without such expertise.
Deciphering Transcriptional and Metabolic Networks Associated with Lysine Metabolism during Arabidopsis Seed Development1[C][W][OA]

In order to elucidate transcriptional and metabolic networks associated with lysine (Lys) metabolism, we utilized developing Arabidopsis (Arabidopsis thaliana) seeds as a system in which Lys synthesis could be stimulated developmentally without application of chemicals and coupled this to a T-DNA insertion knockout mutation impaired in Lys catabolism. This seed-specific metabolic perturbation stimulated Lys accumulation starting from the initiation of storage reserve accumulation. Our results revealed that the response of seed metabolism to the inducible alteration of Lys metabolism was relatively minor; however, that which was observable operated in a modular manner. They also demonstrated that Lys metabolism is strongly associated with the operation of the tricarboxylic acid cycle while largely disconnected from other metabolic networks. In contrast, the inducible alteration of Lys metabolism was strongly associated with gene networks, stimulating the expression of hundreds of genes controlling anabolic processes that are associated with plant performance and vigor while suppressing a small number of genes associated with plant stress interactions. The most pronounced effect of the developmentally inducible alteration of Lys metabolism was an induction of expression of a large set of genes encoding ribosomal proteins as well as genes encoding translation initiation and elongation factors, all of which are associated with protein synthesis. With respect to metabolic regulation, the inducible alteration of Lys metabolism was primarily associated with altered expression of genes belonging to networks of amino acids and sugar metabolism. The combined data are discussed within the context of network interactions both between and within metabolic and transcriptional control systems.
Minimally invasive approaches for gastric cancer—Japanese experiences

Since development of laparoscopy‐assisted distal gastrectomy with lymph node dissection in 1991 in Japan, laparoscopic gastrectomy (LAG) is improving and evolving. Recently, advanced LAG techniques including D2 lymph node dissection or anastomosis after total gastrectomy have been developed. Retrospective and prospective multicenter studies have been conducted for early and non‐early gastric cancers to establish high‐quality evidence. This review summarizes the current trends of minimally invasive approaches for gastric cancer based on current Japanese experiences. J. Surg. Oncol. 2013;107:282–288. © 2012 Wiley Periodicals, Inc.
Modified myocardial performance index is not affected in fetuses with an isolated echogenic focus in the left ventricle

Abstract Objectives: We prospectively investigated the efficacy of modified myocardial performance index (mod-MPI) in the assessment of cardiac functions in fetuses with and without an isolated hyperechogenic focus (IHF) in the left ventricle and compared with conventional fetal echocardiography. Methods: The study group consisted of 50 fetuses with only an IHF in the left ventricle, without any other cardiac or extracardiac anomalies; 50 fetuses without IHF served as controls. All fetal echocardiographic studies were performed between 20th and 24th weeks of gestation. Left ventricular functions were evaluated with both conventional echocardiographic methods (peak velocity of the aortic valve, mitral E/A ratio, fractional shortening) and mod-MPI. Results: There was no statistically significant difference between the groups in terms of maternal age, BMI or gestational age at the time of examination (p > 0.05 for all). No statistically significant differences were found between the findings of conventional echocardiographic measurements and left ventricular mod-MPI between the study and control groups (p > 0.05 for all). Conclusion: Fetal left ventricular mod-MPI is not affected by the presence of an IHF in the fetal left ventricle between 20th and 24th gestational weeks and thus it does not need to be assessed in this situation.
A methodological perspective on behavioral economics and the role of language in economic rationality

In this dissertation, we propose a methodological perspective on the twofold role of language in economic rationality, economists’ uses of language to theorize it and economic agent’s uses of language to express it, can clarify three main issues (and their connections), underlying the behavioral versus standard economics debates: the issue of the theoretical unification regarding the three dimensions of economic rationality, the issue of interdisciplinarity between economics and Psychology and the positive/normative issue within models of individual behaviors. Regarding the positive/normative issue and the role of language in the behaviors of economic agents, the intention is to provide a constructive criticism of contributions from behavioral as well as standard economists. Following the entanglement thesis of philosopher Hilary Puntam and philosophers-economists Vivian Walsh and Amartya Sen, it is argued that both standard and behavioral economists propose an unsatisfying articulation between the positive and normative dimensions of models of individual behaviors; and that recognizing the entanglement of facts, values and conventions can actually be theoretically and empirically fruitful. Paying some attention to the role of language in the behaviors of economic agents may sometimes show that a seemingly irrational behavior can in fact be defended as rational; hence we argue that, and show how, the implicit axiom -- known as ‘description invariance’ -- in standard models of individual behaviors preventing the influence of language needs to be weakened (though not dropped entirely), contrary to the positions of most behavioral and standard economists.
The Relationship between Cerebral Vasoreactivity and Post-Concussive Symptom Severity.

While pathophysiology underlying post-concussion symptom burden is unknown, data suggest that cerebrovascular dysfunction may be among the culprits. We sought to determine whether the degree of impairment in the ability of cerebrovasculature to buffer against changes in arterial gases (vasoreactivity) is associated with concussion symptoms. In 15 participants (19 ± 5 years, 1 week to 1 year post-injury) diagnosed with concussion, we assessed vasoreactivity from the slope of the linear relationship of beat-by-beat middle cerebral artery blood flow velocity (transcranial Doppler ultrasound) to end-tidal CO2 during progressive increases in end-tidal CO2 (air rebreathing). Symptom burden was assessed using the Post-Concussion Symptom Scale. Subsequently, we explored the relationship between vasoreactivity and the severity of post-concussion headache and cognitive difficulties by linear models. During rebreathing, CO2 increased from 32.6 ± 1.6 to 46.8 ± 1.8 mmHg and cerebrovascular conductance (i.e., flow velocity over pressure) increased from 0.48 ± 0.04 to 0.74 ± 0.06 cms-1 mmHg-1. There was a strong linear relationship between the increase in CO2 and in conductance (R2 = 0.81 ± 0.05; p < 0.05). On average, cerebral vasoreactivity was 0.018 ± 0.003 cm-1 s-1 mmHg CO2-1. Although vasoreactivity tended to be somewhat higher in the asymptotic participants (0.019 ± 0.003 vs. 0.015 ± 0.005 cm-1 s-1 mmHg CO2-1), this difference was not statistically significant (p = 0.48). Higher vasoreactivity was strongly associated with more severe headaches (R2 = 0.57; p < 0.01) and worse cognitive symptoms (R2 = 0.71; p < 0.01). Thus, cerebral vasoreactivity relates strongly to post-concussive headache and cognitive symptom burden. This has significant implications for understanding the pathophysiology underlying post-concussive symptom burden and for devising effective treatment options.