Miracle-dz/UniFAR-FTUs huggingface dataset:
On radial basis function network equalization in the GSM system

In this paper we have studied adaptive equalization in the GSM (Global System for Mobile communications) environment using radial basis function (RBF) networks. Equalization is here considered as a classification problem, where the idea is to map the received complex-valued signal into desired binary values using RBF network equalizer. Results prove that the RBF network provides very good bit error rates with acceptable computational complexity. Performance comparisons are made to a linear equalizer, a multilayer perceptron (MLP) network equalizer and to a Viterbi equalizer.
NC381, a Novel Anticancer Agent, Arrests the Cell Cycle in G0-G1 and Inhibits Lung Tumor Cell Growth in Vitro and in Vivo

Although clotrimazole (CLT), an antifungal drug, inhibits tumor cell proliferation and angiogenesis, its clinical application is hampered by significant hepatotoxicity due to the presence of an imidazole moiety. In our attempts to develop CLT analogs that are devoid of imidazole and are as efficacious as CLT, one pharmacophore designated NC381 was generated and shown to inhibit tumor cell growth via a mechanism similar to that of CLT. In vitro, treatment of NCI-H460 nonsmall cell lung cancer (NSCLC) cells with NC381 inhibited growth in a time-dependent manner. Flow cytometric analysis demonstrated that the decrease in cell growth was associated with inhibition of cell cycle progression at the G1-S phase transition, resulting in G0-G1 arrest. There was a concomitant inhibition of cyclin D1 expression and subsequent reduction in the formation of the cyclin D1-CDK4 complex. Consistent with a decrease in the cyclin D1-CDK4 complex, NC381 treatment resulted in significant inhibition of pRb phosphorylation. There also were changes in the activity of cell cycle-related proteins, including p16Ink4 and p27Kip1. Together, these results are consistent with a model in which NC381 arrests cell cycle progression via inhibition of the pathway that promotes exit from the G1 phase of the cell cycle. Furthermore, the clinical applicability of NC381 was evaluated in an in vivo murine xenograft model of human NSCLC (NCI-H460). NC381 treatment resulted in significant inhibition of tumor growth. Given the poor prognosis and the limited treatment options available, the present results underscore the potential of NC381 in the treatment of human NSCLC.
Axon Guidance of Sympathetic Neurons to Cardiomyocytes by Glial Cell Line-Derived Neurotrophic Factor (GDNF)

Molecular signaling of cardiac autonomic innervation is an unresolved issue. Here, we show that glial cell line-derived neurotrophic factor (GDNF) promotes cardiac sympathetic innervation in vitro and in vivo. In vitro, ventricular myocytes (VMs) and sympathetic neurons (SNs) isolated from neonatal rat ventricles and superior cervical ganglia were cultured at a close distance. Then, morphological and functional coupling between SNs and VMs was assessed in response to GDNF (10 ng/ml) or nerve growth factor (50 ng/ml). As a result, fractions of neurofilament-M-positive axons and synapsin-I-positive area over the surface of VMs were markedly increased with GDNF by 9-fold and 25-fold, respectively, compared to control without neurotrophic factors. Pre- and post-synaptic stimulation of β1-adrenergic receptors (BAR) with nicotine and noradrenaline, respectively, resulted in an increase of the spontaneous beating rate of VMs co-cultured with SNs in the presence of GDNF. GDNF overexpressing VMs by adenovirus vector (AdGDNF-VMs) attracted more axons from SNs compared with mock-transfected VMs. In vivo, axon outgrowth toward the denervated myocardium in adult rat hearts after cryoinjury was also enhanced significantly by adenovirus-mediated GDNF overexpression. GDNF acts as a potent chemoattractant for sympathetic innervation of ventricular myocytes, and is a promising molecular target for regulation of cardiac function in diseased hearts.
Constant Delay Enumeration for FO Queries over Databases with Local Bounded Expansion

We consider the evaluation of first-order queries over classes of databases with local bounded expansion. This class was introduced by Nesetril and Ossona de Mendez and generalizes many well known classes of databases, such as bounded degree, bounded tree width or bounded expansion. It is known that over classes of databases with local bounded expansion, first-order sentences can be evaluated in pseudo-linear time (pseudo-linear time means that for all \epsilon there exists an algorithm working in time O(n^{1+\epsilon})). Here, we investigate other scenarios, where queries are not sentences. We show that first-order queries can be enumerated with constant delay after a pseudo-linear preprocessing over any class of databases having locally bounded expansion. We also show that, in this context, counting the number of solutions can be done in pseudo-linear time.
Carbachol-induced desensitization of PLC-b pathway in rat myometrium : downregulation of Gq a / G 11 a

Lajat, Sandrine, Simone Harbon, and Zahra Tanfin. Carbachol-induced desensitization of PLC-b pathway in rat myometrium: downregulation of Gqa/G11a. Am. J. Physiol. 275 (Cell Physiol. 44): C636–C645, 1998. —In the estrogentreated rat myometrium, carbachol increased the generation of inositol phosphates by stimulating the muscarinic receptorGq/G11-phospholipase C-b3 (PLC-b3) cascade. Exposure to carbachol resulted in a rapid and specific (homologous) attenuation of the subsequent muscarinic responses in terms of inositol phosphate production, PLC-b3 translocation to membrane, and contraction. Refractoriness was accompanied by a reduction of membrane muscarinic binding sites and an uncoupled state of residual receptors. Protein kinase C (PKC) altered the functionality of muscarinic receptors and contributed to the initial period of desensitization. A delayed phase of the muscarinic refractoriness was PKC independent and was associated with a downregulation of Gqa/G11a. Atropine failed to induce desensitization as well as Gqa/G11a downregulation, indicating that both events involve active occupancy of the receptor. Prolonged exposure to AlF4 2 reduced subsequent A lF4 2 as well as carbachol-mediated inositol phosphate responses and similarly induced downregulation of Gqa/G11a. Data suggest that a decrease in the level of Gqa/G11a is subsequent to its activation and may account for heterologous desensitization.
Effect of processed and red meat on endogenous nitrosation and DNA damage

Haem in red meat (RM) stimulates the endogenous production of mutagenic nitroso compounds (NOC). Processed (nitrite-preserved red) meat additionally contains high concentrations of preformed NOC. In two studies, of a fresh RM versus a vegetarian (VEG) diet (six males and six females) and of a nitrite-preserved red meat (PM) versus a VEG diet (5 males and 11 females), we investigated whether processing of meat might increase colorectal cancer risk by stimulating nitrosation and DNA damage. Meat diets contained 420 g (males) or 366 g (females) meat/per day. Faecal homogenates from day 10 onwards were analysed for haem and NOC and associated supernatants for genotoxicity. Means are adjusted for differences in male to female ratios between studies. Faecal NOC concentrations on VEG diets were low (2.6 and 3.5 mmol/g) but significantly higher on meat diets (PM 175 ± 19 nmol/g versus RM 185 ± 22 nmol/g; P = 0.75). The RM diet resulted in a larger proportion of nitrosyl iron (RM 78% versus PM 54%; P < 0.0001) and less nitrosothiols (RM 12% versus PM 19%; P < 0.01) and other NOC (RM 10% versus PM 27%; P < 0.0001). There was no statistically significant difference in DNA breaks induced by faecal water (FW) following PM and RM diets (P = 0.80). However, PM resulted in higher levels of oxidized pyrimidines (P < 0.05). Surprisingly, VEG diets resulted in significantly more FW-induced DNA strand breaks than the meat diets (P < 0.05), which needs to be clarified in further studies. Meats cured with nitrite have the same effect as fresh RM on endogenous nitrosation but show increased FW-induced oxidative DNA damage.
Dynamic Remodeling of the Magnetosome Membrane Is Triggered by the Initiation of Biomineralization

ABSTRACT Magnetotactic bacteria produce chains of membrane-bound organelles that direct the biomineralization of magnetic nanoparticles. These magnetosome compartments are a model for studying the biogenesis and subcellular organization of bacterial organelles. Previous studies have suggested that discrete gene products build and assemble magnetosomes in a stepwise fashion. Here, using an inducible system, we show that the stages of magnetosome formation are highly dynamic and interconnected. During de novo formation, magnetosomes first organize into discontinuous chain fragments that are subsequently connected by the bacterial actin-like protein MamK. We also find that magnetosome membranes are not uniform in size and can grow in a biomineralization-dependent manner. In the absence of biomineralization, magnetosome membranes stall at a diameter of ~50 nm. Those that have initiated biomineralization then expand to significantly larger sizes and accommodate mature magnetic particles. We speculate that such a biomineralization-dependent checkpoint for membrane growth establishes the appropriate conditions within the magnetosome to ensure successful nucleation and growth of magnetic particles. IMPORTANCE Magnetotactic bacteria make magnetic nanoparticles inside membrane-bound organelles called magnetosomes; however, it is unclear how the magnetosome membrane controls the biomineralization that occurs within this bacterial organelle. We placed magnetosome formation under inducible control in Magnetospirillum magneticum AMB-1 and used electron cryo-tomography to capture magnetosomes in their near-native state as they form de novo. An inducible system provided the key evidence that magnetosome membranes grow continuously unless they have not properly initiated biomineralization. Our finding that the size of a bacterial organelle impacts its biochemical function is a fundamental advance that impacts our perception of organelle formation and can inform future attempts aimed at creating designer magnetic particles. Magnetotactic bacteria make magnetic nanoparticles inside membrane-bound organelles called magnetosomes; however, it is unclear how the magnetosome membrane controls the biomineralization that occurs within this bacterial organelle. We placed magnetosome formation under inducible control in Magnetospirillum magneticum AMB-1 and used electron cryo-tomography to capture magnetosomes in their near-native state as they form de novo. An inducible system provided the key evidence that magnetosome membranes grow continuously unless they have not properly initiated biomineralization. Our finding that the size of a bacterial organelle impacts its biochemical function is a fundamental advance that impacts our perception of organelle formation and can inform future attempts aimed at creating designer magnetic particles.
Control of MgO·Al2O3 Spinel Inclusions in Stainless Steels

The latest publications regarding the development of technology to control inclusion compositions focusing on MgO·Al2O3 spinel inclusions were summarized in this review article. The problems caused by spinel inclusions, which affect practice as well as products were shown. The formation mechanism of MgO·Al2O3 spinel inclusions is secondly explained thermodynamically from the view points of chemistries of molten steels and slag compositions. Furthermore, crystallization behaviour of spinel was introduced. Countermeasures conducted in practices and laboratories were shown along with some problems still left that should be solved in the future.
A New Technique for Combining Multiple Classifiers using The Dempster-Shafer Theory of Evidence

This paper presents a new classifier combination technique based on the Dempster-Shafer theory of evidence. The Dempster-Shafer theory of evidence is a powerful method for combining measures of evidence from different classifiers. However, since each of the available methods that estimates the evidence of classifiers has its own limitations, we propose here a new implementation which adapts to training data so that the overall mean square error is minimized. The proposed technique is shown to outperform most available classifier combination methods when tested on three different classification problems.
Isolation, propagation, and characterization of a newly recognized pathogen, cilia-associated respiratory bacillus of rats, an etiological agent of chronic respiratory disease

A Gram-negative, filamentous, rod-shaped bacillus which failed to grow in cell-free media was isolated in apparently pure culture from the bronchial scraping and washing of a laboratory rat suffering from chronic respiratory disease by inoculating embryonated chicken eggs via the allantoic route. None of the embryos died during 20 serial passages at weekly intervals. The bacillus was reisolated in embryonated eggs from cesarean-derived barrier-maintained N:SD(SD) rats 8 and 12 weeks after intranasal inoculation with 10th-passage allantoic fluid. The inoculated rats were housed in Horsfall-type units and remained free from other known respiratory pathogens, including mycoplasmas and murine viruses, throughout the study. The bacillus colonized the ciliated epithelial cells of the respiratory tract and caused a marked peribronchial infiltration and hyperplasia of mononuclear cells which progressed with time. The bacillus, ca. 0.2 micron wide by 4 to 6 micron long, stained very poorly with basic aniline dyes but was readily demonstrated with the Warthin-Starry silver technique. It was heat labile (56 degrees C for 30 min); spore forms were not observed. It withstood freeze-thawing and was successfully stored at -70 degrees C. Although no visible means of locomotion was observed with the electron microscope, a slow gliding motility, sometimes with bending and flexing of bacilli apparently adherent to the glass surface, was observed with phase microscopy. As an etiological agent of chronic respiratory disease of rats, this cilia-associated respiratory bacillus (tentatively designated the CAR bacillus) may be the first recognized gliding bacterium known to cause disease in a warm-blooded vertebrate.
Hybrid Epidemics—A Case Study on Computer Worm Conficker

Conficker is a computer worm that erupted on the Internet in 2008. It is unique in combining three different spreading strategies: local probing, neighbourhood probing, and global probing. We propose a mathematical model that combines three modes of spreading: local, neighbourhood, and global, to capture the worm’s spreading behaviour. The parameters of the model are inferred directly from network data obtained during the first day of the Conficker epidemic. The model is then used to explore the tradeoff between spreading modes in determining the worm’s effectiveness. Our results show that the Conficker epidemic is an example of a critically hybrid epidemic, in which the different modes of spreading in isolation do not lead to successful epidemics. Such hybrid spreading strategies may be used beneficially to provide the most effective strategies for promulgating information across a large population. When used maliciously, however, they can present a dangerous challenge to current internet security protocols.
Leaf-wise intersections and Rabinowitz Floer homology

In this paper we explain how critical points of a particular perturbation of the Rabinowitz action functional give rise to leaf-wise intersection points in hypersurfaces of restricted contact type. This is used to derive existence and multiplicity results for leaf-wise intersection points in hypersurfaces of restricted contact type in general exact symplectic manifolds. The notion of leaf-wise intersection points was introduced by Moser [16].
Deficient integration of top-down and bottom-up influences on attention in psychopaths : Potential contribution of the septo-hippocampal system

Introduction There has been an explosion of interest and a great deal of progress in the field of Rice, 2001), the development of a reliable method for assessing psychopathy has enabled researchers to demonstrate its outstanding clinical utility in the field of criminal justice. During the past decade investigators have generated a wealth of evidence that psychopathy, as measured by the PCL-R, is a potent predictor of general criminal behavior Given its outstanding predictive validity, there is strong interest in understanding the psychological and biological processes associated with psychopathic behavior. To the extent that investigators are able to characterize the predisposing factors, it will facilitate the early detection of high risk individuals and the development of interventions to prevent the onset or reduce the severity of the disorder. , our laboratory has been using a physiological model to generate and test hypotheses concerning the biopsychological processes associated with psychopathy. This model and its associated body of evidence have given rise to the response modulation hypothesis. Response modulation involves a brief and relatively automatic shift of attention from the effortful organization and implementation of goal-directed behavior to its evaluation. According to the response modulation hypothesis, primary psychopaths are deficient in response modulation and this information processing deficit results in the dysregulated expression of prepotent responses. Originally, the response modulation model generated hypotheses based on the behavioral consequences of septo-hippocampal-orbitofrontal (SHF) system lesions in animals. However, with time, it became possible to use the growing evidence on the performance of psychopathic individuals to generate more theory-based predictions regarding the implications of a response modulation deficit for cognitive (see Patterson & Newman, 1993) and affective (see Newman & Lorenz, 2003) information processing. Although the experimental methods used to operationalize response modulation have evolved along with the model during the past 20 years, the basic explanatory construct is essentially the same. Specifically, response modulation deficits involve a failure to accommodate information that is not part of a person's primary, prepotent, or dominant response set. In light of the longstanding connection between the response modulation hypothesis and septo-hippocampal system (SHS) and the fact that the SHS has received relatively little attention in the field of psychopathy during the past 20 years, our goal for this chapter is to re-evaluate the connection between the SHS and the psychopath's response modulation deficits. Toward this end, we (1) translate response modulation into neural network terms; (2) clarify our assumptions …
DOCTOR OF MEDICAL SCIENCE DANISH MEDICAL JOURNAL

I. Steenholdt C, Enevold C, Ainsworth MA, Brynskov J, Thomsen OO, Bendtzen K. Genetic polymorphisms of tumour necrosis factor receptor superfamily 1b and fas ligand are associated with clinical efficacy and/or acute severe infusion reactions to infliximab in Crohn's disease. Aliment Pharmacol Ther. 2012;36:650-659. II. Steenholdt C, Brynskov J, Thomsen OØ, Munck LK, Fallingborg J, Christensen LA, Pedersen G, Kjeldsen J, Jacobsen BA, Oxholm AS, Kjellberg J, Bendtzen K, Ainsworth MA. Individualized therapy is more cost-effective than dose intensification in Crohn's disease patients who fail anti-TNF treatment: a randomized, controlled trial. Gut 2014;63:919-927. III. Steenholdt C, Brynskov J, Thomsen OØ, Munck LK, Fallingborg J, Christensen LA, Pedersen G, Kjeldsen J, Jacobsen BA, Oxholm AS, Kjellberg J, Bendtzen K, Ainsworth MA. Individualized Therapy Is a Long-Term Cost-Effective Method Compared to Dose Intensification in Crohn's Disease Patients Failing Infliximab. Dig Dis Sci. 2015;60:2762-2770. IV. Steenholdt C, Bendtzen K, Brynskov J, Thomsen OØ, Munck LK, Christensen LA, Pedersen G, Kjeldsen J, Ainsworth MA. Changes in serum through levels of infliximab during treatment intensification but not in anti-infliximab antibody detection are associated with clinical outcomes after therapeutic failure in Crohn’s disease. J Crohns Colitis 2015;9:238-245. V. Steenholdt C, Bendtzen K, Brynskov J, Thomsen OØ, Ainsworth MA. Clinical implications of measuring drug and anti-drug antibodies by different assays when optimizing infliximab treatment failure in Crohn’s disease: post-hoc analysis of a randomized controlled trial. Am J Gastroenterol 2014;109:1055-1064. VI. Frederiksen MT, Ainsworth MA, Brynskov J, Thomsen OØ, Bendtzen K, Steenholdt C. Antibodies against infliximab (IFX) are associated with de novo development of antibodies to adalimumab (ADL) and therapeutic failure in IFX-toADL switchers with inflammatory bowel disease. Inflamm Bowel Dis 2014;20:1714-1721. VII. Steenholdt C, Frederiksen MT, Bendtzen K, Ainsworth MA, Thomsen OØ, Brynskov J. Time course and clinical implications of development of antibodies against adalimumab in patients with inflammatory bowel disease. J Clin Gastroenterol. 2015 Jul 9. [Epub ahead of print] VIII. Steenholdt C, Molazahi A, Ainsworth MA, Brynskov J, Thomsen OØ, J Seidelin. Outcome after discontinuing infliximab in patients with inflammatory bowel disease in clinical remission: An observational Danish single center study. Scand J Gastroenterol. 2012;47:518-527. IX. Steenholdt C, Brynskov J, Thomsen OØ, Munck LK, Christensen LA, Pedersen G, Kjeldsen J, Ainsworth MA. Implications of infliximab treatment failure and influence of personalized treatment on patient-reported health-related quality of life and productivity outcomes in Crohn’s disease. J Crohns Colitis. 2015;9:1032-1042.
Low Heart Rate Variability in a 2-Minute Electrocardiogram Recording Is Associated with an Increased Risk of Sudden Cardiac Death in the General Population: The Atherosclerosis Risk in Communities Study

Low heart rate variability (HRV) has been linked to increased total mortality in the general population; however, the relationship between low HRV and sudden cardiac death (SCD) is less well-characterized. The goal of this study was to evaluate the relationship between low HRV and SCD in a community-based cohort. Our cohort consisted of 12,543 participants from the Atherosclerosis Risk in Communities (ARIC) study. HRV measures were derived from 2-minute electrocardiogram recordings obtained during the baseline exam (1987–89). Time domain measurements included the standard deviation of all normal RR intervals (SDNN) and the root mean squared successive difference (r-MSSD). Frequency domain measurements included low frequency power (LF) and high frequency (HF) power. During a median follow-up of 13 years, 215 SCDs were identified from physician adjudication of all coronary heart disease deaths through 2001. In multivariable adjusted Cox proportional hazards models, each standard deviation decrement in SDNN, LF, and HF were associated with 24%, 27% and 16% increase in SCD risk, respectively. Low HRV is independently associated with increased risk of SCD in the general population.
Ferromagnetic/superconducting proximity effect in La_(0.7)Ca_(0.3)MnO_(3)/YBa_(2)Cu_(3)O_(7-δ) superlattices

We study the interplay between magnetism and superconductivity in high-quality YBa_(2)Cu_(3)O_(7)(YBCO)/La_(0.7)Ca_(0.3)MnO_(3)(LCMO) superlattices. We find evidence for the YBCO superconductivity depression in the presence of the LCMO layers. We show that due to its short coherence length, superconductivity survives in the YBCO down to a much smaller thickness in the presence of the magnetic layer than in low Tc superconductors. We also find that for a fixed thickness of the superconducting layer, superconductivity is depressed over a thickness interval of the magnetic layer in the 100 nm range. This is a much longer length scale than that predicted by the theory of ferromagnetic/superconducting proximity effect.