Miracle-dz/UniFAR-FTUs huggingface dataset:
Early detection of airway wall remodeling and eosinophilic inflammation in preschool wheezers.

RATIONALE It is unclear when the pathologic features of asthma first appear. We hypothesized that eosinophilic airway inflammation and epithelial reticular basement membrane (RBM) thickening, absent in wheezy infants, would be present in preschool children with severe, recurrent wheeze. OBJECTIVES To compare RBM thickness and inflammation in endobronchial biopsies (EBs) from wheezy preschool children and age-matched control subjects. METHODS EBs were obtained from wheezy preschool children (aged 3 mo to 5 yr), undergoing a clinically indicated fiberoptic bronchoscopy. Subjects undergoing fiberoptic bronchoscopy to investigate stridor acted as nonasthmatic controls. RBM thickness was measured and the density of subepithelial, immunologically distinct inflammatory cells was determined and expressed as a volume fraction (%). EBs from 16 children (median age, 29 [7-57] mo) with wheeze confirmed by video questionnaire (confirmed wheezers [CWs]), 14 with reported wheeze (reported wheezers [RWs]) (median age, 17 [8-58] mo), and 10 control subjects (median age, 19 [5-42] mo) were assessed. MEASUREMENTS AND MAIN RESULTS RBM thickness in the three groups was as follows: CWs: median, 4.6 (range, 2.9-8.0) microm; RWs: median, 3.5 (2.1-5.4) microm; control subjects: median, 3.8 (2.5-4.7) microm. RBM was significantly thicker in CWs than in control subjects (P < 0.05). Eosinophil density was as follows: CWs: median, 1.07% (range, 0.0-3.52%); RWs: median, 0.72% (0.0-2.04%); control subjects: median, 0.0% (0.0-1.05%). Eosinophilic inflammation was significantly greater in CWs compared with control subjects (P < 0.05). There were no between-group differences for any other inflammatory cell phenotype. CONCLUSIONS The characteristic pathologic features of asthma in adults and school-aged children develop in preschool children with confirmed wheeze between the ages of 1 and 3 years, a time when intervention may modify the natural history of asthma.
Offshoring, Plant Survival and Employment Growth

This paper empirically investigates the effects of offshoring on plant survival and employment growth using data on the Danish manufacturing plants during the period 1995–2006. To control for the potential endogeneity of the offshoring decision, the paper uses instrumental variables and propensity score‐matching approaches. The data allow me to control for the heterogeneity between the units by using firm‐level offshoring activities in different regions and performing the empirical analysis on plant-level aggregation, which is shown to be of crucial importance. Using firm as a unit of observation, the effect of offshoring is, if any, very small. However, using plant as a unit of observation, there are strong indications that offshoring plays a much larger role for the extensive and intensive margin of adjustments. The results reveal that plants survival prospect is higher if the main offshoring is located in high‐wage countries; lower if it is located in low‐wage countries; and not affected if it is located in medium‐wage countries. Finally, the results also reveal that depending on where the main offshoring is located, the growth rate of low‐skilled employment is 2 to 8 per cent lower in plants of offshoring firms.
No evidence for association of the TP53 12139 and the BAX−248 polymorphisms with endemic pemphigus foliaceus (fogo selvagem)

Pemphigus foliaceus (PF) is an autoimmune bullous epidermal disease, characterized by autoantibodies specific to the desmosomal protein desmoglein 1 (dsg1) and by acantholysis, the rupture of the cellular junctions among keratinocytes. Known also as fogo selvagem (wild fire) in Brazil, the disease has distinct epidemiological characteristics, being endemic in certain regions of South America. It is a multifactorial (complex) disease, with oligo‐ or polygenic disease susceptibility. In view of the previously reported evidences of a role for apoptosis dysregulation in pemphigus pathogenesis, we hypothesized that genetic variants of molecules participating in apoptosis may contribute to interindividual variation of susceptibility to PF. The TP53 12139(G,C) and the BAX−248(G,A) single nucleotide polymorphisms (SNP) were analysed in a genetic association study. The allelic, genotypic and allele carrier frequencies for these SNPs did not differ statistically between the patient and the control groups, for both the Euro‐ and the Afro‐Brazilian population strata. The results of this study lead us to conclude that, although the TP53 and BAX alleles analysed differ functionally, this variation does not alter the functionality of the molecules in a way that would interfere with the development of the disease.
Thyroid function and cholesterol level: paradoxical findings in large groups of population with high cholesterol food intake.

OBJECTIVE To compare the levels of serum cholesterol with thyroid function as estimated by the level of thyrotropin and free thyroxine with possible participation of thyroperoxidase antibodies in large number of adults examined within large field surveys focused on the evaluation of thyroid status of Slovak rural population. SUBJECTS AND METHODS Serum level of cholesterol and thyrotropin (TSH) was estimated in a total of 2786 adults. In addition, in 2038 of them also the level of free thyroxine (FT4), total triiodothyronine (TT3), cholesterol, triglycerides and phospholipids was measured. The levels of TSH, anti-TPO and FT4 were estimated by supersensitive electrochemiluminiscent immunoassay using the automatic system Elecsys (Roche, Switzerland). RESULTS A total of 2786 adults was stratified into 7 groups according to the range of TSH level as related to generally recognized level of thyroid function, e.g. 1. TSH <0.10 mU/L (overt hyperthyroidism, N=41), 2. TSH 0.11-0.30 mU/L (overt or subclinical hyperthyroidism, N=149), 3. TSH 0.31-2.50 mU/L (normal level, N=1750), 4. TSH 2.51-4.50 ("high normal" level, N=607), 5 TSH 4.51-6.50 (mild or incipient subclinical hypothyroidism, N=137), 6. TSH 6.51-10.00 mU/L (mild hypothyroidism, N=50), 7. TSH 10.01-99.00 mU/L (severe hypothyroidism, N=53). The average levels of cholesterol in all groups were very similar ranging from 5.53 to 6.17 mmol/L and no interrelations with TSH level were found. In addition, no considerable differences between these groups were found when considering the levels of medians, upper quartiles and 90th percentiles of individual groups. When male and female subjects were divided into age groups according to the decades, an age dependent increase of cholesterol level was found in both sexes. The fraction of 2038 subjects was divided into the same TSH related groups as defined above. Similarly as above, no considerable differences in cholesterol, triglycerides and phospholipids level were observed. However, the levels of FT4 and TT3 were significantly decreasing with the increase of TSH level which confirmed the continuing decrease of thyroid function. The frequency of positive anti-TPO in subjects with TSH >6.5 mU/l (71/86 = 82.5%) was significantly higher than that in subjects with TSH <6.5 mU/l (468/1952 = 23.9%). CONCLUSIONS No difference in the level of cholesterol and triglycerides was found in large groups of rural adults from Slovakia with various thyroid function as estimated by the level of TSH, FT4, TT3 and anti-TPO. It is assumed that this interrelation resulted from very high cholesterol intake due to inappropriate general nutritional status of rural population resulting from the consumption of unhealthy foods.
The Cost of Carbon: Capital Market Effects of the Proposed Emission Trading Scheme (ETS)

In March 2008, the Australian Government announced its intention to introduce a national Emissions Trading Scheme (ETS), now expected to start in 2015. This impending development provides an ideal setting to investigate the impact an ETS in Australia will have on the market valuation of Australian Securities Exchange (ASX) firms. This is the first empirical study into the pricing effects of the ETS in Australia. Primarily, we hypothesize that firm value will be negatively related to a firm's carbon intensity profile. That is, there will be a greater impact on firm value for high carbon emitters in the period prior (2007) to the introduction of the ETS, whether for reasons relating to the existence of unbooked liabilities associated with future compliance and/or abatement costs, or for reasons relating to reduced future earnings. Using a sample of 58 Australian listed firms (constrained by the current availability of emissions data) which comprise larger, more profitable and less risky listed Australian firms, we first undertake an event study focusing on five distinct information events argued to impact the probability of the proposed ETS being enacted. Here, we find direct evidence that the capital market is indeed pricing the proposed ETS. Second, using a modified version of the Ohlson (1995) valuation model, we undertake a valuation analysis designed not only to complement the event study results, but more importantly to provide insights into the capital market's assessment of the magnitude of the economic impact of the proposed ETS as reflected in market capitalization. Here, our results show that the market assesses the most carbon intensive sample firms a market value decrement relative to other sample firms of between 7% and 10% of market capitalization. Further, based on the carbon emission profile of the sample firms we imply a ‘future carbon permit price’ of between AUD$17 per tonne and AUD$26 per tonne of carbon dioxide emitted. This study is more precise than industry reports, which set a carbon price of between AUD$15 to AUD$74 per tonne.
Different approaches to obtaining consent for follow-up result in biased samples

Background Many injury studies use samples of hospital patients. If a study requires further contact, consent is usually required but the sample may be biased if many fail to consent. Objective To determine whether wording requiring ‘active’ consent resulted in more refusals than wording that was ‘passive’—that is, where consent is implied in the absence of direct refusal. Methods Subjects were injured children seen in the emergency departments in five hospitals where the Canadian Hospital Injury Reporting and Prevention Program (CHIRPP) operates. For CHIRPP, parents or older children complete a one-page questionnaire to describe the injury; one question seeks consent to follow-up for research. Three of the hospitals use passive wording for this question and two use active wording. All cases where CHIRPP coordinators completed forms using the medical record were treated as refusals. It was hypothesised that there would be a significant association between the form of wording (active or passive) and the rate of consent, and that this association would be affected by socio-demographic and clinical variables. Results On average, 64.5% of parents gave consent for follow-up at hospitals using passive consent wording versus 42% where active consent wording was used. Passive wording consistently yielded a higher percentage of consents for all variables. The differences were greater than 5% for families living in census tracts with low median household incomes and greater than 10% for those age 15–19 years. For parent completed forms the adjusted OR for active wording was 0.48 (95% CI 0.43 to 0.54). Conclusion Caution is needed when interpreting results from studies using hospital samples, especially when wording of consent for follow-up requires direct affirmation.
An Emerging Markets Analysis of the Piotroski F Score

We examine the F score in global emerging markets and show there is a meaningful premium attached to high F score stocks which is unrelated to the size, value and momentum premiums. It is larger for high value stocks, moderately higher for high momentum stocks and unrelated to stock size. This suggests the usual explanation for the power of the F score – investor neglect of high F score stocks – is incomplete because big cap and high momentum stocks are typically not neglected. We conjecture another factor shaping the premium to high F score stocks is the confirmation bias.
Financial structure, production, and productivity: evidence from the U.S. food manufacturing industry

This study integrates production and financing to examine the impacts of financial structure change on the production, profitability, and productivity growth in the U.S. food manufacturing industry. Empirical results show that during the period covered by this study, agency cost associated with increased debt use by this industry negatively affected its output growth, input demand, profitability, and overall productivity growth. Dividend payment positively contributed to the production and performance of this industry via signaling benefit. However, the negative effects of increased debt use by this industry far outweighed the positive contribution of dividend payment. The U.S. food industry achieved a 0.9% average annual productivity growth, which came primarily from technological progress and capital adjustment. The rapid increase in debt use by this industry was responsible for slowing down the pace of productivity growth via its negative contribution to the total factor productivity growth. Capital expansion was the principal driver of output growth and profitability in this industry. Copyright 2005 International Association of Agricultural Economics.
Modernity, Modernization and the Deinstitutionalization of Incremental Budgeting in Local Government

Governmental reform programs in the UK have a long history of failed attempts to end incrementalism in local government budgeting. Drawing on structuration theory, incrementalism is presented as institutionalized organizational behaviour. From this perspective, the recent New Labour reform agenda may be interpreted via a theory of de-institutionalization. The approach is illustrated through an analysis of recent developments in a large UK metropolitan authority where new political structures, inspection regimes and regulatory pressures are beginning to challenge incrementalism. A new belief in the measurability of public sector performance seems to be legitimized by a post-bureaucratic modernity rather than any significant technical innovations.
How Political Connections Affect Corporate Environmental Performance: The Mediating Role of Green Subsidies

ABSTRACT This study investigates the relationship between political connections and corporate environmental performance, and examines the role of government green subsidies on this relationship within the current Chinese context. Using data from publicly traded private manufacturing firms, empirical results show that politically connected firms are significantly more likely to obtain green subsidies than non-connected firms. Assisted by green subsidies, firms with political connections show better environmental performance than those without. Our findings reveal the mechanism by which corporate political connections influence environmental performance.
The Distribution of Wealth in Australia-A Survey

This paper surveys and analyzes the available evidence on the distribution of wealth in Australia. On the basis of this evidence, it is argued that the cross-section distribution of personal wealth reveals considerable concentration in the top tail, with the top 1 per cent of adult individuals holding around 25 per cent of private wealth. The inequality of wealth revealed in the cross-section distribution among the top 10 per cent of wealth holders is not significantly reduced when adjustments are made to correct for life-cycle influences. Although the proportion of wealth held by the top 1 per cent of adult individuals has decreased sharply since World War I, the second to tenth percentiles have almost the same proportion in the 1960s and 1970s as in 1915.
Time estimation in patients with right or left medial-temporal lobe resection

Patients with either left or right antero-medial-temporal lobe (MTL) resection were investigated as to their ability to reproduce and produce three durations (5, 14, or 38 s) in three conditions (silence, counting, articulatory suppression). The results showed that patients with unilateral MTL lesions did not differ from controls when they had to encode the duration of a visual stimulus in order to reproduce it. By contrast, patients with right MTL lesions underestimated all three durations, compared with controls and with patients with left MTL resection, when they had to produce durations given in chronometric units. This finding suggests that the right MTL retains long-term representations of the conventional units necessary to the accurate production of durations.
Upside and Downside Risk Exposures of Currency Carry Trades via Tail Dependence

Currency carry trade is the investment strategy that involves selling low interest rate currencies in order to purchase higher interest rate currencies, thus profiting from the interest rate differentials. This is a well known financial puzzle to explain, since assuming foreign exchange risk is uninhibited and the markets have rational risk-neutral investors, then one would not expect profits from such strategies. That is, according to uncovered interest rate parity (UIP), changes in the related exchange rates should offset the potential to profit from such interest rate differentials. However, it has been shown empirically, that investors can earn profits on average by borrowing in a country with a lower interest rate, exchanging for foreign currency, and investing in a foreign country with a higher interest rate, whilst allowing for any losses from exchanging back to their domestic currency at maturity. This paper explores the financial risk that trading strategies seeking to exploit a violation of the UIP condition are exposed to with respect to multivariate tail dependence present in both the funding and investment currency baskets. It will outline in what contexts these portfolio risk exposures will benefit accumulated portfolio returns and under what conditions such tail exposures will reduce portfolio returns.
Determinants of customers' online purchase intention: an empirical study in India

Purpose – According to Associated Chambers of Commerce and Industry of India (ASSOCHAM), the size of the Indian online retail industry is INR 2000 crore and the industry is projected a steady annual growth rate of 35 per cent to reach INR 7000 crore by 2015. Given the growing importance of the online retail industry in India, it remains imperative for web retailers and internet marketers to understand the determinants of online customers' purchase intention to decipher what is important to the Indian online customer. This paper attempts to identify the determinants of online purchase intention among youth in the Indian context.Design/methodology/approach – Based on a detailed literature review, customer online purchase intention shopping orientation factors such as impulse purchase orientation, brand orientation and quality orientation were considered along with online trust and prior online purchase experience. The results are based on 95 valid responses received from the online survey.Findings – The res.
Influence of environmental factors on the occurrence of Ixodes ricinus ticks in the urban locality of Brno–Pisárky, Czech Republic

ABSTRACT The occurrence of Ixodes ricinus ticks was observed in the suburban locality of Brno–Pisárky (South Moravia, Czech Republic) from March to November, 1996 to 2002. A total of 2,813 ticks was collected. Statistical tests divided the activity of ticks into three periods during the year. The curve of seasonality had two peaks with a maximum in May and August, with a significantly larger number of specimens collected during this period compared to other months. The abundance of ticks during Spring and Autumn months was comparable. All developmental stadia of ticks were found in this locality. The number of larvae, males, and females was not significantly different, but the occurrence of nymphs was significantly greater. Except for the year 2000, there were no statistically significant differences in tick abundance. Tick activity was not dependent on humidity but did vary directly with temperature. This relation had a linear character and could be described by the equation y = 8.3 + 1.8x.
Differing requirements for actin and myosin by plant viruses for sustained intercellular movement

The actin cytoskeleton has been implicated in the intra- and intercellular movement of a growing number of plant and animal viruses. However, the range of viruses influenced by actin for movement and the mechanism of this transport are poorly understood. Here we determine the importance of microfilaments and myosins for the sustained intercellular movement of a group of RNA-based plant viruses. We demonstrate that the intercellular movement of viruses from different genera [tobacco mosaic virus (TMV), potato virus X (PVX), tomato bushy stunt virus (TBSV)], is inhibited by disruption of microfilaments. Surprisingly, turnip vein-clearing virus (TVCV), a virus from the same genus as TMV, did not require intact microfilaments for normal spread. To investigate the molecular basis for this difference we compared the subcellular location of GFP fusions to the 126-kDa protein and the homologous 125-kDa protein from TMV and TVCV, respectively. The 126-kDa protein formed numerous large cytoplasmic inclusions associated with microfilaments, whereas the 125-kDa protein formed few small possible inclusions, none associated with microfilaments. The dependence of TMV, PVX, and TBSV on intact microfilaments for intercellular movement led us to investigate the role of myosin motors in this process. Virus-induced gene silencing of the Nicotiana benthamiana myosin XI-2 gene, but not three other myosins, inhibited only TMV movement. These results indicate that RNA viruses have evolved differently in their requirements for microfilaments and the associated myosin motors, in a manner not correlated with predicted phylogeny.
On the Spatial Distribution of Base Stations and Its Relation to the Traffic Density in Cellular Networks

The spatial distribution of base stations (BSs) and traffic demands is essential for efficient network planning and BS sleeping, which are key elements of green cellular networking. This paper investigates their statistics, relation, and modeling, based on large-scale measurement data from commercial cellular networks. The spatial distribution of BSs shows not only high nonuniformity over a region but also diverse patterns in different regions, and thus the widely used homogeneous Poisson point process can only approximate the BS patterns in a specific small area. Therefore, the inhomogeneous PPP (IPPP), in particular, the Cox point process with spatially varying intensity is used to model the BS distribution over any spatial scale. To model the intensity distribution of the IPPP, we exploit the relation, shown to be sublinear, between the BS distribution and the peak hour (PH) traffic density, based on the finding that the PH traffic density can be approximated by a log-normal distribution. Finally, we propose a spatial modeling framework for network simulations, and discuss potential applications of the proposed spatial distribution model of the BS patterns and the PH traffic density.
Competition and market power in the European airline industry: 1976-90

In this paper, we study the market power of European airlines in an oligopoly structure with product differentiation for the period 1976-1990 and test the monopoly hypothesis (Captain, 1993). The paper analyzes the level of competition among eight major European airlines and finds little evidence for market power in the industry over that period. One of our main findings is that the high prices in Europe are not entirely due to the bilateral agreements (leading to possible monopoly power), but rather are a result of very high cost structures in the industry. These results are broadly in agreement with those of Roeller and Sickles (1994) which analyzes these issues in the European Industry by estimating a structural, two-stage game. © 1997 John Wiley & Sons, Ltd.