Miracle-dz/UniFAR-FTUs huggingface dataset:
Prenatal Diagnosis of Fetal Ventriculomegaly: Agreement between Fetal Brain Ultrasonography and MR Imaging

BACKGROUND AND PURPOSE: Accurate measurement of the lateral ventricles is of paramount importance in prenatal diagnosis. Possible conflicting classifications caused by their measurement in different sectional planes by sonography and MR imaging are frequently raised. The objective of our study was to evaluate the agreement between ultrasonography and MR imaging in the measurement of the lateral ventricle diameter in the customary sectional planes for each technique. MATERIALS AND METHODS: Measurement of both lateral ventricles was performed prospectively in 162 fetuses from 21 to 40 weeks of gestational age referred for evaluation due to increased risk for cerebral pathology. The mean gestational age for evaluation was 32 weeks. The measurements were performed in the customary plane for each technique: axial plane for sonography and coronal plane for MR imaging. RESULTS: The 2 techniques yielded results in substantial agreement by using intraclass correlation and κ coefficient score tests. When we assessed the clinical cutoff of 10 mm, the κ score was 0.94 for the narrower ventricle and 0.84 for the wider ventricle, expressing almost perfect agreement. The Bland-Altman plot did not show any trend regarding the actual width of the ventricle, gestational week, or interval between tests. Findings were independent for fetal position, sex, and indication for examination. CONCLUSIONS: Our study indicates excellent agreement between fetal brain ultrasonography and MR imaging as to the diagnosis of fetal ventriculomegaly in the customarily used sectional planes of each technique.
Phonetic variability and grammatical knowledge: an articulatory study of Korean place assimilation*

The study reported here uses articulatory data to investigate Korean place assimilation of coronal stops followed by labial or velar stops, both within words and across words. The results show that this place-assimilation process is highly variable, both within and across speakers, and is also sensitive to factors such as the place of articulation of the following consonant, the presence of a word boundary and, to some extent, speech rate. Gestures affected by the process are generally reduced categorically (deleted), while sporadic gradient reduction of gestures is also observed. We further compare the results for coronals to our previous findings on the assimilation of labials, discussing implications of the results for grammatical models of phonological/phonetic competence. The results suggest that speakers' language-particular knowledge of place assimilation has to be relatively detailed and context-sensitive, and has to encode systematic regularities about its obligatory/variable application as well as categorical/gradient realisation.
On finite sums of reciprocals of distinct $n$th powers.

Introduction* It has long been known that every positive rational number can be represented as a finite sum of reciprocals of distinct positive integers (the first proof having been given by Leonardo Pisano [6] in 1202). It is the purpose of this paper to characterize {cf. Theorem 4) those rational numbers which can be written as finite sums of reciprocals of distinct nth. powers of integers, where n is an arbitrary (fixed) positive integer and "finite sum" denotes a sum with a finite number of summands. It will follow, for example, that p\q is the finite sum of reciprocals of distinct squares if and only if
Casting curved shadows on curved surfaces

Shadowing has historically been used to increase the intelligibility of scenes in electron microscopy and aerial survey. Various methods have been published for the determination of shadows in computer synthesized scenes. The display of shadows may make the shape and relative position of objects in such scenes more comprehensible; it is a technique lending vividness and realism to computer animation. To date, algorithms for the determination of shadows have been restricted to scenes constructed of planar polygons. A simple algorithm is described which utilizes Z-buffer visible surface computation to display shadows cast by objects modelled of smooth surface patches. The method can be applied to all environments, in fact, for which visible surfaces can be computed. The cost of determining the shadows associated with each light source is roughly twice the cost of rendering the scene without shadows, plus a fixed transformation overhead which depends on the image resolution. No extra entities are added to the scene description in the shadowing process. This comprehensive algorithm, which permits curved shadows to be cast on curved surfaces, is contrasted with a less costly method for casting the shadows of the environment on a single ground plane. In order to attain good results, the discrete nature of the visible-surface computations must be treated with care. The effects of dither, interpolation, and geometric quantization at different stages of the shadowing algorithm are examined. The special problems posed by self-shadowing surfaces are described.
Stachybotrys atra Growth and Toxin Production in Some Building Materials and Fodder under Different Relative Humidities

Growth of Stachybotrys atra and its toxin production on some building materials and in animal fodder were studied at relative humidities ranging from 78 to 100%. Toxins were detected by biological assays and chemical methods. Strong growth of the fungus and presence of macrocyclic trichothecenes, mainly satratoxins G and H, were detected on wallpaper and gypsum boards and in hay and straw at saturation conditions. On pine panels, S. atra grew well, but neither biological toxicity nor production of macrocyclic trichothecenes was observed.
Regular Tree Grammars as a Formalism for Scope Underspecification

We propose the use of regular tree grammars (RTGs) as a formalism for the underspecified processing of scope ambiguities. By applying standard results on RTGs, we obtain a novel algorithm for eliminating equivalent readings and the first efficient algorithm for computing the best reading of a scope ambiguity. We also show how to derive RTGs from more traditional underspecified descriptions.
Multiplex semantics for deontic logic

This multiplex semantics incorporates multiple relations of deontic accessibility or multiple preference rankings on alternative worlds to represent distinct normative standards. This provides a convenient framework for deontic logic that allows conflicts of obligation, due either to conflicts between normative standards or to incoherence within a single standard. With the multiplex structures, two general senses of "ought" may be distinguished, an indefinite sense under which something is obligatory when it is enjoined by some normative standard and a core sense for when something is enjoined by all normative standards. Multiple normative standards may themselves be given a preferential order; this leads to a concept of ranked obligation. This paper presents the foundations of this multiplex semantics and the propositional deontic logics they define.
Pediatric Quality of Life while Supported with a Ventricular Assist Device.

OBJECTIVE Ventricular assist devices (VADs) have emerged as an important treatment option for bridging pediatric patients with heart failure to transplant. VADs have shown improved survival; however, the pediatric quality of life (QoL) while on VAD support is unknown. We aimed to evaluate the QoL of our pediatric patients while supported with a VAD. DESIGN In this prospective study, pediatric patients who underwent VAD placement, and their parents, were administered a generic Pediatric Quality of Life Inventory (PedsQL) 4.0 pre-VAD implant, when feasible, after the acute postoperative period, and then periodically until heart transplant or death. Their final scores while on support were compared with three previously reported groups: healthy controls, outpatients with severe heart disease, and children after heart transplant. RESULTS From January 2008 to July 2014, 13 pediatric patients required VAD support greater than 2 weeks and completed a PedsQL. The mean age at implant was 10.0 ± 4.2 years and median duration of support was 1.6 (0.5-19.7) months. Eleven (85%) patients survived to transplant with one (8%) patient remaining alive on support. The median duration of support prior to their final PedsQL was 1.4 (0.5-11.4) months. Patients self-reported significantly (P < .05) lower total and physical QoL scores when compared with all three comparison groups. Self-reported psychosocial QoL scores were significantly lower than healthy controls only. Parent proxy-reported scores were significantly lower than all three comparison groups for all three categories (P < .05). CONCLUSIONS A large deficit exists in the total QoL of pediatric patients supported by a VAD compared with outpatient management of severe heart disease or postheart transplant patients; however, VAD patients do represent a group with more severe heart failure. Improvements in QoL must be made, as time spent with a VAD will likely continue to increase.
The segregation of boron to grain boundaries in solution-treated Type 316 austenitic stainless steel

AbstractThe distribution of boron in samples of Type 316 austenitic steel (containing 18 ppm by weight of B), cooled at a rate of either 50 or 500 degC/s from solution-treatment temperatures in the range 900–1350°C, has been determined using an optical microscope autoradiographic technique. Segregation of the boron to the grain-boundary regions was detected in the specimens cooled at the slower rate from the higher solution-treatment temperatures, the extent of the intergranular segregation diminishing with decreasing solution-treatment temperature; grain-boundary segregation of the boron was not detected in the specimens cooled at 500 degC/s irrespective of the solution-treatment temperature. A theoretical model is proposed to account for this non-equilibrium grain-boundary segregation of boron during cooling, based on the existence of mobile vacancy-boron complexes. The predictions of the model are in good agreement with the experimental observations if realistic values for the vacancy-boron binding ene.
Who Adopts Improved Fuels and Cookstoves? A Systematic Review

Background: The global focus on improved cookstoves (ICSs) and clean fuels has increased because of their potential for delivering triple dividends: household health, local environmental quality, and regional climate benefits. However, ICS and clean fuel dissemination programs have met with low rates of adoption. Objectives: We reviewed empirical studies on ICSs and fuel choice to describe the literature, examine determinants of fuel and stove choice, and identify knowledge gaps. Methods: We conducted a systematic review of the literature on the adoption of ICSs or cleaner fuels by households in developing countries. Results are synthesized through a simple vote-counting meta-analysis. Results: We identified 32 research studies that reported 146 separate regression analyses of ICS adoption (11 analyses) or fuel choice (135 analyses) from Asia (60%), Africa (27%), and Latin America (19%). Most studies apply multivariate regression methods to consider 7–13 determinants of choice. Income, education, and urban location were positively associated with adoption in most but not all studies. However, the influence of fuel availability and prices, household size and composition, and sex is unclear. Potentially important drivers such as credit, supply-chain strengthening, and social marketing have been ignored. Conclusions: Adoption studies of ICSs or clean energy are scarce, scattered, and of differential quality, even though global distribution programs are quickly expanding. Future research should examine an expanded set of contextual variables to improve implementation of stove programs that can realize the “win-win-win” of health, local environmental quality, and climate associated with these technologies.
A Study of Fingerprints in Relation to Gender and Blood Group among Residents of Maiduguri, Nigeria.

Fingerprints are classified and documented on the basis of ridge patterns. The impressions made by the pattern of any individual remain unchanged throughout life. The study was carried out on 400 individuals among which 200 were males and 200 were females subjects having different ABO blood groups, all the 10 fingerprints were divided into loops, whorl and arches. The results showed that majority of the subjects belonged to blood group O. The finger print pattern of loops had the highest frequency while arches were the least. Blood group O were mostly associated with the loop pattern while AB had the least frequency in all the fingerprint patterns. Males had the highest number with the loops and whorls while females had the highest number of arches. It was concluded that there was an association between distribution of fingerprint patterns, blood group and gender and thus prediction of gender and blood group of a person was possible based on the fingerprint patterns.
Improved hardness and wear properties of B-ion implanted polycarbonate

Polycarbonate (Lexan) was implanted with 100 and 200 keV B^+ ions to doses of 0.26, 0.78, and 2.6 × 10^15 ions/cm^2 at room temperature (<100 °C). Mechanical characterization of implanted materials was carried out by nanoindentation and sliding wear tests. The results showed that the hardness of implanted polycarbonate increased with increasing ion energy and dose, attaining hardness up to 3.2 GPa at a dose of 2.6 × 10^15 ions/cm^2 for 200 keV ions, which is more than 10 times that of the unimplanted polymer. Wear properties were characterized using a reciprocating tribometer with nylon, brass, and SAE 52100 Cr-steel balls with 0.5 and 1 N normal forces for 10000 cycles. The wear mode varied widely as a function of ion energy, dose, wear ball type, and normal load. For given ion energy, load, and ball type conditions, there was an optimum dose that produced the greatest wear resistance and lowest friction coefficient. For polycarbonate implanted with 0.78 × 10^15 ions/cm^2, the nylon ball produced no wear after 10000 cycles. Moreover, the overall friction coefficient was reduced by over 40% by implantation. The results suggest that the potential of ion-beam technology for improving polycarbonate is significant, and that surface-sensitive mechanical properties can be tailored to meet the requirements for applications demanding hardness, wear, and abrasion resistance.
Therapeutics , Targets , and Chemical Biology Oxidative Stress-Regulated Lentiviral TK / GCV Gene Therapy for Lung Cancer Treatment

Nuclear factor erythroid-2 related factor 2 (Nrf2) is a transcription factor that regulates protection against a wide variety of toxic insults to cells, including cytotoxic cancer chemotherapeutic drugs. Many lung cancer cells harbor a mutation in either Nrf2 or its inhibitor Keap1 resulting in permanent activation of Nrf2 and chemoresistance. In this study, we sought to examine whether this attribute could be exploited in cancer suicide gene therapy by using a lentiviral (LV) vector expressing herpes simplex virus thymidine kinase (HSV-TK/ GCV) under the regulation of antioxidant response element (ARE), a cis-acting enhancer sequence that binds Nrf2. In human lung adenocarcinoma cells in which Nrf2 is constitutively overexpressed, ARE activity was found to be high under basal conditions. In this setting, ARE-HSV-TKwasmore effective than a vector in which HSV-TK expressionwas driven by a constitutively active promoter. In amouse xenograftmodel of lung cancer, suicide gene therapy with LV-ARE-TK/GCV was effective compared with LV-PGK-TK/GCV in reducing tumor size. We conclude that ARE-regulated HSV-TK/GCV therapy offers a promising approach for suicide cancer gene therapy in cells with high constitutive ARE activity, permitting a greater degree of therapeutic targeting to those cells. Cancer Res; 72(23); 6227–35. 2012 AACR.
Genomewide homozygosity mapping and molecular analysis of a candidate gene located on 22q13 (fibulin-1) in a previously undescribed vitreoretinal dystrophy.

OBJECTIVES To localize the gene that causes an autosomal recessively inherited vitreoretinal dystrophy that has not been described, to our knowledge, and to analyze a candidate gene mapped to 22q13 (fibulin-1 [FBLN1]). METHODS Homozygosity mapping with 500 microsatellite markers spread over the whole genome (mean distance, 7.2 centimorgans [cM]) and mutation analysis of the complete coding region of FBLN1. RESULTS Homozygosity for all analyzed markers was found in the 4 affected siblings in a region on chromosome 22 encompassing 12 cM from D22S444 (centromeric) to D22S1170 (telomeric). Lod scores were between 0.017 and 2.36 (theta = 0). A mutation analysis of the complete coding region of FBLN1, which encodes interacting extracellular matrix proteins, revealed 4 previously undescribed single nucleotide polymorphisms. CONCLUSIONS A genomewide homozygosity mapping analysis supported the hypothesis that the gene responsible for a unique vitreoretinal dystrophy is located on chromosome 22q13. No obviously pathogenic mutation was found in the candidate gene, FBLN1.
Towards a Quantitative OCT Image Analysis

Background Optical coherence tomography (OCT) is an invaluable diagnostic tool for the detection and follow-up of retinal pathology in patients and experimental disease models. However, as morphological structures and layering in health as well as their alterations in disease are complex, segmentation procedures have not yet reached a satisfactory level of performance. Therefore, raw images and qualitative data are commonly used in clinical and scientific reports. Here, we assess the value of OCT reflectivity profiles as a basis for a quantitative characterization of the retinal status in a cross-species comparative study. Methods Spectral-Domain Optical Coherence Tomography (OCT), confocal Scanning-Laser Ophthalmoscopy (SLO), and Fluorescein Angiography (FA) were performed in mice (Mus musculus), gerbils (Gerbillus perpadillus), and cynomolgus monkeys (Macaca fascicularis) using the Heidelberg Engineering Spectralis system, and additional SLOs and FAs were obtained with the HRA I (same manufacturer). Reflectivity profiles were extracted from 8-bit greyscale OCT images using the ImageJ software package (http://rsb.info.nih.gov/ij/). Results Reflectivity profiles obtained from OCT scans of all three animal species correlated well with ex vivo histomorphometric data. Each of the retinal layers showed a typical pattern that varied in relative size and degree of reflectivity across species. In general, plexiform layers showed a higher level of reflectivity than nuclear layers. A comparison of reflectivity profiles from specialized retinal regions (e.g. visual streak in gerbils, fovea in non-human primates) with respective regions of human retina revealed multiple similarities. In a model of Retinitis Pigmentosa (RP), the value of reflectivity profiles for the follow-up of therapeutic interventions was demonstrated. Conclusions OCT reflectivity profiles provide a detailed, quantitative description of retinal layers and structures including specialized retinal regions. Our results highlight the potential of this approach in the long-term follow-up of therapeutic strategies.
Nanoencapsulation of natural triterpenoid celastrol for prostate cancer treatment

Celastrol (CL), a triterpenoid extracted from the Chinese herb Tripterygium wilfordii, has recently attracted interest for its potential antitumor effects. However, unfavorable physicochemical and pharmacokinetics properties such as low solubility, poor bioavailability, and systemic toxicity, are limiting its therapeutic application. In this context, the development of innovative nanocarriers can be useful to overcome these issues, and nanoencapsulation would represent a powerful strategy. In this study, we developed novel CL-loaded poly(ε-caprolactone) nanoparticles (NPs), and investigated their antiproliferative efficacy on prostate cancer cells. CL-NPs were prepared using a nanoprecipitation method and fully characterized by physicochemical techniques. The antiproliferative effects on LNCaP, DU-145, and PC3 cell lines of CL-NPs, compared to those of free CL at different concentrations (0.5, 1.0, and 2.0 µM), were investigated. Moreover, fluorescence microscopy was utilized to examine the cellular uptake of the nanosystems. Furthermore, to elucidate impact of nanoencapsulation on the mechanism of action, Western analyses were conducted to explore apoptosis, migration, proliferation, and angiogenesis alteration of prostate cancer cells. The results confirmed that CL-NPs inhibit proliferation dose dependently in all prostate cancer cells, with inhibitory concentration50 less than 2 µM. In particular, the NPs significantly increased cytotoxicity at lower/medium dose (0.5 and 1.0 µM) on DU145 and PC3 cell lines with respect to free CL, with modulation of apoptotic and cell cycle machinery proteins. To date, this represents the first report on the development of biocompatible polymeric NPs encapsulating CL. Our findings offer new perspectives for the exploitation of developed CL-NPs as suitable prototypes for prostate cancer treatment.
Ge-on-Si Single-Photon Avalanche Diode Detectors: Design, Modeling, Fabrication, and Characterization at Wavelengths 1310 and 1550 nm

The design, modeling, fabrication, and characterization of single-photon avalanche diode detectors with an epitaxial Ge absorption region grown directly on Si are presented. At 100 K, a single-photon detection efficiency of 4% at 1310 nm wavelength was measured with a dark count rate of ~ 6 megacounts/s, resulting in the lowest reported noise-equivalent power for a Ge-on-Si single-photon avalanche diode detector (1×10-14 WHz-1/2). The first report of 1550 nm wavelength detection efficiency measurements with such a device is presented. A jitter of 300 ps was measured, and preliminary tests on after-pulsing showed only a small increase (a factor of 2) in the normalized dark count rate when the gating frequency was increased from 1 kHz to 1 MHz. These initial results suggest that optimized devices integrated on Si substrates could potentially provide performance comparable to or better than that of many commercially available discrete technologies.