Miracle-dz/UniFAR-FTUs huggingface dataset:
Graduate Students and Community-Based Learning

This article describes opportunities for graduate students to engage in service-learning and community-based research as emerging scholars. Initiatives at the University of Notre Dame are presented to illustrate potentials. Such community-oriented practices help address recent criticisms about graduate education, and serve to integrate intellectual inquiry with informed practice. Introduction Early in this decade, the traditional research-oriented approach to graduate education came under fire. Citing a report published by the Pew Charitable Foundation (Golde & Dore, 2001), Thomas & Lambert (2005) suggest that the “emphasis on research in doctoral training leaves new Ph.D.’s unprepared for faculty responsibilities such as teaching, collegial evaluation, curricular planning, and collaborative effort” (p. 1), and that “new graduates . appear to lack an understanding of professional ethics and an interest and commitment to community outreach and service, both of which are required by many public and private institutions” (p. 2). Engaging graduate students in community-based educational approaches is an efficient and relevant means to address such concerns. While service-learning has developed typically within undergraduate education, graduate students demonstrate interest, and some find their way into service-related initiatives. Less common are opportunities to teach using a service-learning pedagogy, or to practice a mode of scholarship that is community driven. Below, employing categories in the experiential learning model of Kolb (1984), we outline ways to provide relevant experiences for graduate students. Doing so will enhance their effectiveness as teachers. Perhaps more importantly, it will ready developing scholars to prepare undergraduates to address social challenges and to employ their own scholarly expertise similarly. Preparing graduate students in this way can also assist in reviving the civic mission of higher education. From Service-Learning to Community-Based Research The field and practice of service-learning has expanded over the last two decades, with increased attention to graduate students. Discussions of service-learning can be found in literature on graduate studies in business education, psychology, and, perhaps most prominently, the health fields (e.g., nursing education). For example, Feen-Calligan (2008) describes a graduate course she offers in art therapy—through which students work with individuals who are homeless—while Ethridge (2006) outlines servicelearning in teacher education.
Predicting well-being in managers: Test of a positive psychology model

Contemporary scholars in vocational, applied, and organizational psychology have emphasized that working must be understood as a relational act with important implications for worker well-being. Drawing upon emergent research extending the constructs of adult attachment security and authenticity to the workplace, this study tested a positive psychological model linking adult attachment orientations, and both experienced and expressed features of work authenticity, to the prediction of well-being within a sample of business managers. Findings indicated that, controlling for their gender and length of managerial experience, managers’ levels of adult attachment security and work authenticity accounted for significant and incremental variance in their reported levels of work stress and job satisfaction. In general, managers with high levels of adult attachment security and work authenticity reported lower work stress and higher job satisfaction. Implications of these findings for the counseling of distressed managers are briefly discussed.
Wideband Beam-Scanning Circularly Polarized Inclined Slots Using Ridge Gap Waveguide

A wideband circularly polarized (CP) frequency-dependent slot antenna array is designed for beam scanning using the ridge gap waveguide (RGW) technology. The merge between both the printed and the RGW technologies for providing a wideband CP antenna array is newly implemented here. The designed CP antenna has been fabricated, and measurement results are provided and compared to the full-wave analysis. A measured antenna axial ratio (AR) and impedance bandwidths of ~ 21% are achieved from 12.5 to 15.5 GHz. The proposed antenna preserves its CP characteristics of AR below 3 dB while achieving continuous frequency beam scanning from backward to forward directions including broadside radiation that covers +15° to -15° with an average gain of 12.5 dBi.
Nearest neighbor classi ® er : Simultaneous editing and feature selection

Nearest neighbor classi®ers demand signi®cant computational resources (time and memory). Editing of the reference set and feature selection are two dierent approaches to this problem. Here we encode the two approaches within the same genetic algorithm (GA) and simultaneously select features and reference cases. Two data sets were used: the SATIMAGE data and a generated data set. The GA was found to be an expedient solution compared to editing followed by feature selection, feature selection followed by editing, and the individual results from feature selection and editing. Ó 1999 Elsevier Science B.V. All rights reserved.
Public knowledge, use and attitude toward multivitamin supplementation: A cross-sectional study among general public

Background and Objective: The use of supplements has increased substantially in the past few decades. The present study is an effort to explore pattern of use, knowledge and attitude toward consumption of multivitamin supplements among the general public. Materials and Methods: A descriptive cross-sectional study on 120 adult participants from the general public was conducted. The participants were interviewed and information was collected in a predesigned structured questionnaire. The data was analyzed and expressed as counts and percentages. Results: Of the 120 study participants, 66 were males and 54 were females. Results revealed that 68.33% (82) of the participants were users of multivitamin supplements. Out of the users, 69.5% (57) participants consumed on the advice of doctors, 18.2% (15) were self-prescribers while 12.1% (10) relied on advice of family or friends. Among the users, 70.96% considered such supplements to be helpful. Reasons quoted for self-medication use of multivitamins were multiple such as maintenance of general health (55%), to allay weakness or fatigue (20%), to improve appetite (15%) etc. Majority of the participants were unaware regarding the correct indications for multivitamin supplementation. Regarding knowledge about the natural sources of these vitamins, as many as 76% showed ignorance. Conclusion: Finding from this study suggests that multivitamin use is highly prevalent and the majority of the participants were ignorant of any possible harm or drug interactions. In light of this, there is a need to adopt certain educational interventions to minimize self-directed supplement use and increase awareness regarding their correct usage.
Soil Uncertainty and Its Influence on Simulated G/G max and Damping Behavior

In this paper, recently developed probabilistic elastoplasticity was applied in simulating cyclic behavior of clay. A simple von Mises elastic–perfectly plastic material model was used for simulation. Probabilistic soil parameters, elastic shear modulus (Gmax) and undrained shear strength (su), needed for the simulation were obtained from correlations with the standard penetration test (SPT) N-value. It has been shown that the probabilistic approach to geo-material modeling captures some of the important aspects—the modulus reduction, material damping ratio, and modulus degradation—of cyclic behavior of clay reasonably well, even with the simple elastic–perfectly plastic material model.
Preparing Preservice Teachers’ Minds, Hearts and Actions for Teaching in Remote Indigenous Contexts

This paper examines some challenges we confront working with preservice teachers prior to serving in remote Indigenous communities. Some challenges include what preservice teachers bring to their studies - subjectivities, experiential understandings of teaching and notions of childhood/adolescence, culture and social justice, all of which involve minds, emotions and our notions of our places in society. Some challenges involve linking new notions of teaching to what they already know which may entail unlearning before relearning. Some challenges involve making sense of the theory/action dialectic - teasing out links between strongly held but unarticulated values, beliefs and actions that derive from them. Some challenges involve anticipating what it might be like to live and teach in a remote setting and preparing to work effectively across cultures. I then discuss how we might tackle them in the light of productive pedagogy and culturally relevant pedagogy (Osborne, 2001a, 2001b).
New Bioinformatics-Based Discrimination Formulas for Differentiation of Thalassemia Traits From Iron Deficiency Anemia

Thalassemia traits (TTs) and iron deficiency anemia (IDA) are the most common disorders of hypochromic microcytic anemia (HMA). The present study aimed to differentiate TTs from IDA by analyzing discrimination formulas and provides comprehensive data of hemoglobin disorders prevalent in Pakistan. Among 12 published discrimination formulas, 6 formulas-MI, EF, G&K, RDWI, R, and HHI-were the most reliable to discriminate TTs from IDA. The failure cutoff values were improved by the random forest (RF) decision-tree approach. Moreover, the Shine and Lal (S&L) formula, which completely failed to discriminate IDA from TTs with original cutoff value (<1530), improved with the use of new proposed cutoff value (<1016) and was found to successfully discriminate all cases of TTs from those with IDA. In addition, 2 newly proposed formulas discriminated TTs from IDA more reliably than the original 12 formulas assessed. The proposed formulas could play a crucial role for clinicians to discriminate between TTs and IDA.
Validation of the High-Risk Pregnancy Stress Scale in a sample of hospitalized Greek high-risk pregnant women

ABSTRACT The aim of the authors in this study was to determine the psychometric properties of the Greek adaptation of the High-Risk Pregnancy Stress Scale (HRPSS) in a sample of high-risk hospitalized pregnant women. The sample consisted of 133 high-risk pregnant women with gestational age from 9 to 37 weeks. Data were collected between February and June of 2014. HRPSS was “forward–backward” translated from English to Greek. Principal axis factoring with promax rotation was used to test the factor structure of the HRPSS. Measures of state anxiety (STAI) and depressive symptoms (EPDS) were used to assess the convergent validity of the HRPSS. Exploratory factor analysis suggested three factors: concerns of pregnancy, movement restriction, and isolation and restriction of external activities. Construct validity was confirmed by computing correlations between the HRPSS and constructions of anxiety and depressive symptoms. Internal consistency reliability was satisfactory (α = 0.813). The original factor structure of the HRPSS was only partly replicated. The results of the exploratory factor analysis suggested that a three-factor solution instead of a two-factor solution would be the most adequate. The HRPSS is an appropriate measure for assessing the levels of concerns regarding pregnancy outcome, movement restriction, isolation, and external activity restrictions in Greek high-risk pregnant women.
A Probabilistic Approach for Animal-Caused Outages in Overhead Distribution Systems

Faults caused by animals are a significant factor in the reliability of distribution systems. Examination of historical data on outages recorded by a utility in Kansas showed that the occurrences of animal-caused faults, most of which are caused by squirrels, are dependent on weather conditions and the time of the year. It was observed that the majority of animal-caused outages take place on fair weather days, which are the days with temperature between 40 degrees F and 85 degrees F with no other weather activity. Also, the breeding cycle and behavioral patterns of squirrels over the year has a strong correlation with the animal-caused outages in different months of the year. Population density of squirrels will have an influence on the number of outages caused by animals in overhead distribution systems, but reliable data on animal population density could not be found, thus an adequate direct relationship could not be established. In this paper, a Bayesian model is constructed for prediction of animal-caused outages in overhead distribution systems given the type of month and the number of fair weather days per week. The model uses historical data for training purposes and predicts the number of animal-caused outages per week given a combination of month type and number of fair weather days per week. A confidence interval is built around the predicted values of animal-caused outages, and the percentage of observed values lying within the confidence limits are computed in order to obtain accuracy of the predictions. Also, the time-sequences of monthly averaged predictions are compared with the observed values. The model is illustrated with seven years of data obtained for a service territory of a utility in Kansas
‘Against the grain’: over 75 years and joining a community exercise programme

This study explores the meanings that 22 men over 75 years attributed to their experience when joining a community exercise programme. Information gathered via interviews was analysed by inductive analysis. Four dominant themes emerged and these provide a framework for representing the findings. All men believed a physical active lifestyle was desirable for well-being and quality of life, although engagement at various levels is strongly influenced by the social construction of ageing and one’s personal history. Being physically active via a programme in later life is as much an embodied as a technical endeavour. It is also as much biographical as biological, and for ongoing engagement exercise must be deemed purposeful to self, irrespective of whether or not what occurs is in accordance with the scientific script prescribed for optimal health. Just being ‘older’ poses a variety of challenges to adopting a physically active lifestyle in the later years, something the men in this study imply needs to be better understood.
How Structure Defines Affinity in Protein-Protein Interactions

Protein-protein interactions (PPI) in nature are conveyed by a multitude of binding modes involving various surfaces, secondary structure elements and intermolecular interactions. This diversity results in PPI binding affinities that span more than nine orders of magnitude. Several early studies attempted to correlate PPI binding affinities to various structure-derived features with limited success. The growing number of high-resolution structures, the appearance of more precise methods for measuring binding affinities and the development of new computational algorithms enable more thorough investigations in this direction. Here, we use a large dataset of PPI structures with the documented binding affinities to calculate a number of structure-based features that could potentially define binding energetics. We explore how well each calculated biophysical feature alone correlates with binding affinity and determine the features that could be used to distinguish between high-, medium- and low- affinity PPIs. Furthermore, we test how various combinations of features could be applied to predict binding affinity and observe a slow improvement in correlation as more features are incorporated into the equation. In addition, we observe a considerable improvement in predictions if we exclude from our analysis low-resolution and NMR structures, revealing the importance of capturing exact intermolecular interactions in our calculations. Our analysis should facilitate prediction of new interactions on the genome scale, better characterization of signaling networks and design of novel binding partners for various target proteins.
The role of exercise

Lack of physical activity results in overweight and unfit people. People generally ask their doctors for advice on diet and exercise in order to look better. Regular physical activity contributes to overall wellbeing and not simply to improved appearance. Total physical fitness results in improved muscle strength, improved muscle resistance, flexibility and cardiovascular fitness. This can be achieved by exercising for at least 30 minutes for a minimum of 3 times a week. Cycling, swimming, walking and running are excellent forms of exercise because they use the large muscle groups. People should aim to exercise at 70 - 80% of their maximum heart rate (calculated as 220 minus age - unless on rate-reducing cardiovascular drugs).
KU135, a Novel Novobiocin-Derived C-Terminal Inhibitor of the 90-kDa Heat Shock Protein, Exerts Potent Antiproliferative Effects in Human Leukemic Cells

The 90-kDa heat shock protein (Hsp90) assists in the proper folding of numerous mutated or overexpressed signal transduction proteins that are involved in cancer. Consequently, there is considerable interest in developing chemotherapeutic drugs that specifically disrupt the function of Hsp90. Here, we investigated the extent to which a novel novobiocin-derived C-terminal Hsp90 inhibitor, designated KU135, induced antiproliferative effects in Jurkat T-lymphocytes. The results indicated that KU135 bound directly to Hsp90, caused the degradation of known Hsp90 client proteins, and induced more potent antiproliferative effects than the established N-terminal Hsp90 inhibitor 17-allylamino-demethoxygeldanamycin (17-AAG). Closer examination of the cellular response to KU135 and 17-AAG revealed that only 17-AAG induced a strong up-regulation of Hsp70 and Hsp90. In addition, KU135 caused wild-type cells to undergo G2/M arrest, whereas cells treated with 17-AAG accumulated in G1. Furthermore, KU135 but not 17-AAG was found to be a potent inducer of mitochondria-mediated apoptosis as evidenced, in part, by the fact that cell death was inhibited to a similar extent by Bcl-2/Bcl-xL overexpression or the depletion of apoptotic protease-activating factor-1 (Apaf-1). Together, these data suggest that KU135 inhibits cell proliferation by regulating signaling pathways that are mechanistically different from those targeted by 17-AAG and as such represents a novel opportunity for Hsp90 inhibition.
Niche-mediated depletion of the normal hematopoietic stem cell reservoir by Flt3-ITD–induced myeloproliferation

Although previous studies suggested that the expression of FMS-like tyrosine kinase 3 (Flt3) initiates downstream of mouse hematopoietic stem cells (HSCs), FLT3 internal tandem duplications (FLT3 ITDs) have recently been suggested to intrinsically suppress HSCs. Herein, single-cell interrogation found Flt3 mRNA expression to be absent in the large majority of phenotypic HSCs, with a strong negative correlation between Flt3 and HSC-associated gene expression. Flt3-ITD knock-in mice showed reduced numbers of phenotypic HSCs, with an even more severe loss of long-term repopulating HSCs, likely reflecting the presence of non-HSCs within the phenotypic HSC compartment. Competitive transplantation experiments established that Flt3-ITD compromises HSCs through an extrinsically mediated mechanism of disrupting HSC-supporting bone marrow stromal cells, with reduced numbers of endothelial and mesenchymal stromal cells showing increased inflammation-associated gene expression. Tumor necrosis factor (TNF), a cell-extrinsic potent negative regulator of HSCs, was overexpressed in bone marrow niche cells from FLT3-ITD mice, and anti-TNF treatment partially rescued the HSC phenotype. These findings, which establish that Flt3-ITD–driven myeloproliferation results in cell-extrinsic suppression of the normal HSC reservoir, are of relevance for several aspects of acute myeloid leukemia biology.
Quantum computing: an introduction

The basic ideas of quantum computation are introduced by a brief discussion of Bennett (1973, 1982) and Fredkin's (1982, 1997) ideas of reversible computation. After some remarks about Deutsch's (1985) pioneering work on quantum complexity and Shor's (1996) factorisation algorithm, quantum logic gates, qubits and registers are discussed. The role of quantum entanglement is stressed and Grover's (1997) quantum search algorithm described in detail. The paper ends with a review of the current experimental status of quantum computers.
The Effects of Video Game Controls on Hostility, Identification, and Presence

Seventy-two male college undergraduates at a large southeastern university played a video game in one of two conditions: using a traditional handheld controller or using motion-based controls. Results showed that using motion-based controls significantly increased measures of hostility, identification with the avatar, and impacted a sense of self presence with the game. Results indicate motion-based controls, although helping to create a bond with the game's avatar, do not necessarily create a feeling of immersion into the game environment.
The Inclusion of Excluded Majorities in South Asian Parliaments: Women, Youth, and the Working Class

This article provides a new perspective on parliamentary representation in South Asia, focusing on the collective under-representation of population majorities based on the macro-demographic categories of age, class, and gender. Situating this analysis within debates on descriptive representation, it presents the first comparative analysis of the contemporary demographic characteristics of members of parliament (MPs) in Bangladesh, Bhutan, India, Nepal, Pakistan, and Sri Lanka. Highlighting three major gaps in parliamentary representation, it finds quotas, proportional representation electoral systems, and leftist parties to have positively impacted the descriptive representation of South Asian women, the working class, and young adults.
Kinetic evidence for pentachlorophenol-dependent growth of a dehalogenating population in a pentachlorophenol- and acetate-fed methanogenic culture.

A method was developed to evaluate growth of a reductively dechlorinating bacterial population within a pentachlorophenol (PCP)- and acetate-fed, mixed, methanogenic culture. In 6- to 12-day experiments, a computer-monitored/feedback-controlled bioreactor was used to maintain constant pH, temperature, and acetate concentration, while transformation of multiple PCP additions was monitored. The potential at a platinum electrode, EPt, was not controlled externally, but was maintained constant at -0.25 +/- 0.002 V (vs. SHE) by iron sulfides in the medium and the activity of the culture. PCP was reductively dechlorinated at the ortho position, yielding 3, 4,5-trichlorophenol (3,4,5-TCP) via 2,3,4,5-tetrachlorophenol (2,3,4, 5-TeCP). Below an initial PCP concentration of 0.5 microM, PCP was transformed to 3,4,5-TCP within 3 to 6 h. Biomass concentration changes were small during this period, and PCP and 2,3,4,5-TeCP transformations were modeled as pseudo-first-order reactions. Increases in pseudo-first-order rate constants for PCP and 2,3,4, 5-TeCP were directly related to the amount of PCP transformed to 3,4, 5-TCP, suggesting enrichment of a PCP-catabolizing population. Moreover, rate constant increases were independent of the amount of acetate consumed, changes in the overall volatile suspended solids (VSS) concentration, and the experimental duration. When PCP was added to the reactor at increasingly shorter time intervals in an exponential pattern, pseudo-first-order rate constants increased exponentially. An average rate constant doubling time of 1.7 days (1. 4 to 2.3 d) was estimated. While the VSS concentration of the culture increased 60% in an 8-day period, pseudo-first-order rate constants increased by a factor of approximately 6. This large increase in transformation rate constants suggests growth of a bacterial population capable of using PCP and 2,3,4,5-TeCP as terminal electron acceptors.