Miracle-dz/UniFAR-FTUs huggingface dataset:
How policy can help develop and sustain workforce capacity in UK dementia research: insights from a career tracking analysis and stakeholder interviews

Objectives To identify research support strategies likely to be effective for strengthening the UK's dementia research landscape and ensuring a sustainable and competitive workforce. Design Interviews and qualitative analysis; systematic internet search to track the careers of 1500 holders of UK doctoral degrees in dementia, awarded during 1970–2013, to examine retention in this research field and provide a proxy profile of the research workforce. Setting and participants 40 interviewees based in the UK, whose primary role is or has been in dementia research (34 individuals), health or social care (3) or research funding (3). Interviewees represented diverse fields, career stages and sectors. Results While the UK has diverse strengths in dementia research, needs persist for multidisciplinary collaboration, investment in care-related research, supporting research-active clinicians and translation of research findings. There is also a need to better support junior and midlevel career opportunities to ensure a sustainable research pipeline and future leadership. From a sample of 1500 UK doctorate holders who completed a dementia-related thesis in 1970–2013, we identified current positions for 829 (55%). 651 (43% of 1500) could be traced and identified as still active in research (any field) and 315 (21%) as active in dementia research. Among recent doctoral graduates, nearly 70% left dementia research within 4–6 years of graduation. Conclusions A dementia research workforce blueprint should consider support for individuals, institutions and networks. A mix of policy interventions are needed, aiming to attract and retain researchers; tackle bottlenecks in career pathways, particularly at early and midcareer stages (eg, scaling-up fellowship opportunities, rising star programmes, bridge-funding, flexible clinical fellowships, leadership training); and encourage research networks (eg, doctoral training centres, succession and sustainability planning). Interventions should also address the need for coordinated investment to improve multidisciplinary collaboration; balanced research portfolios across prevention, treatment and care; and learning from evaluation.
Use of High-Flow Nasal Cannula Support in the Emergency Department Reduces the Need for Intubation in Pediatric Acute Respiratory Insufficiency

Objectives The objective of this study was to determine whether the use of heated, humidified, high-flow nasal cannula (HFNC) therapy is associated with a decreased need for intubation in patients presenting to a pediatric emergency department (PED) and admitted to a pediatric intensive care unit (PICU) with acute respiratory insufficiency (ARI). Methods A retrospective study of all patients admitted from the PED to the PICU with ARI from January 2006 through December 2009. Patients admitted before the availability of HFNC (cohort 1) were compared with those admitted after the availability of HFNC but before implementation of an institution-wide guideline on pediatric HFNC usage (cohort 2) and those admitted after the implementation of a pediatric HFNC usage guideline (cohort 3). Results After controlling for age, month of admission, type of respiratory illness, and severity of illness, there was an 83% reduction in the odds of intubation in the PED in cohort 3 compared with cohort 1 (odds ratio, 0.17; 95% confidence interval, 0.06-0.50; P = 0.001). There was no significant change in mortality or median PICU length of stay after the introduction of HFNC. Conclusions High-flow nasal cannula used early in the development of pediatric ARI is associated with a decreased the need for intubation and mechanical ventilation.
Corneal Wound Healing Is Compromised by Immunoproteasome Deficiency

Recent studies have revealed roles for immunoproteasome in regulating cell processes essential for maintaining homeostasis and in responding to stress and injury. The current study investigates how the absence of immunoproteasome affects the corneal epithelium under normal and stressed conditions by comparing corneas from wildtype (WT) mice and those deficient in two immunoproteasome catalytic subunits (lmp7 −/−/mecl-1 −/−, L7M1). Immunoproteasome expression was confirmed in WT epithelial cells and in cells of the immune system that were present in the cornea. More apoptotic cells were found in both corneal explant cultures and uninjured corneas of L7M1 compared to WT mice. Following mechanical debridement, L7M1 corneas displayed delayed wound healing, including delayed re-epithelialization and re-establishment of the epithelial barrier, as well as altered inflammatory cytokine production compared to WT mice. These results suggest that immunoproteasome plays an important role in corneal homeostasis and wound healing.
Technology-aided programs for post-coma patients emerged from or in a minimally conscious state

Post-coma persons in a minimally conscious state (MCS) or emerged/emerging from such state (E-MCS), who are affected by extensive motor impairment and lack of speech, may develop an active role and interact with their environment with the help of technology-aided intervention programs. Although a number of studies have been conducted in this area during the last few years, new evidence about the efficacy of those programs is warranted. These three studies were an effort in that direction. Study I assessed a technology-aided program to enable six MCS participants to access preferred environmental stimulation independently. Studies II and III assessed technology-aided programs to enable six E-MCS participants to make choices. In Study II, three of those participants were led to choose among leisure and social stimuli, and caregiver interventions automatically presented to them. In Study III, the remaining three participants were led to choose (a) among general stimulus/intervention options (e.g., songs, video-recordings of family members, and caregiver interventions); and then (b) among variants of those options. The results of all three studies were largely positive with substantial increases of independent stimulation access for the participants of Study I and independent choice behavior for the participants of Studies II and III. The results were analyzed in relation to previous data and in terms of their implications for daily contexts working with MCS and E-MCS persons affected by multiple disabilities.
The Influence of Categories on Perception: Explaining the Perceptual Magnet Effect as Optimal Statistical Inference Speech Sounds

A variety of studies have demonstrated that organizing stimuli into categories can affect the way the stimuli are perceived. We explore the influence of categories on perception through one such phenomenon , the perceptual magnet effect, in which discriminability between vowels is reduced near prototyp-ical vowel sounds. We present a Bayesian model to explain why this reduced discriminability might occur: It arises as a consequence of optimally solving the statistical problem of perception in noise. In the optimal solution to this problem, listeners' perception is biased toward phonetic category means because they use knowledge of these categories to guide their inferences about speakers' target productions. Simulations show that model predictions closely correspond to previously published human data, and novel experimental results provide evidence for the predicted link between perceptual warping and noise. The model unifies several previous accounts of the perceptual magnet effect and provides a framework for exploring categorical effects in other domains. The influence of categories on perception is well known in domains ranging from speech sounds to artificial categories of objects. Liberman, Harris, Hoffman, and Griffith (1957) first described categorical perception of speech sounds, noting that lis-teners' perception conforms to relatively sharp identification boundaries between categories of stop consonants and that whereas between-category discrimination of these sounds is nearly perfect, within-category discrimination is little better than chance. Similar patterns have been observed in the perception of colors as the representation of objects belonging to artificial categories that are learned over the course of an experiment (Goldstone, 1994; Goldstone, Lippa, & Shiffrin, 2001). All of these categorical effects are characterized by better discrimination of between-category contrasts than within-category contrasts, although the magnitude of the effect varies between domains. In this article, we develop a computational model of the influence of categories on perception through a detailed investigation of one such phenomenon, the perceptual magnet effect (Kuhl, 1991), which has been described primarily in vowels. The perceptual magnet effect involves reduced discriminability of speech sounds near phonetic category prototypes. For several reasons, speech sounds, particularly vowels, provide an excellent starting point for assessing a model of the influence of categories on perception. Vowels are naturally occurring, highly familiar stimuli that all listeners have categorized. As discussed later, a precise two-dimensional psychophysical map of vowel space can be provided, and using well-established techniques, discrimination of pairs of speech sounds can be systematically investigated under well-defined conditions so that perceptual maps …
Association of an abnormality of neutrophil chemotaxis in human periodontal disease with a cell surface protein

Localized juvenile periodontitis (LJP) is characterized by severe, early-onset, molar and incisor bone loss; neutrophil chemotaxis disorders; and a high prevalence of Actinobacillus actinomycetemcomitans infection. LJP is further characterized by significant familial aggregation of the disease. Recent work in our laboratory has demonstrated the selective depletion of a surface glycoprotein of 110,000 Mr (GP110) from LJP neutrophils by using surface labeling with [14C]formaldehyde and autofluorography. The function of GP110 is unknown; however, it does not appear to be a chemotactic factor receptor. Rather, it is bound by a monoclonal antibody (NCD-1) that recognizes a neutrophil differentiation antigen and which itself alters neutrophil chemotactic and secreting functions. To quantify GP110 on LJP and normal neutrophils, fluorescein-labeled NCD-1 was bound to neutrophils and the amount of fluorescence was evaluated by using cytofluorography. Our results indicate that there is a quantifiable reduction (40%) of GP110 on the surface of LJP and GJP neutrophils, compared with controls. Other patients with neutrophil defects express normal quantities of GP110, suggesting disease specificity. Our data suggest that GP110 may be a useful disease marker for LJP and may provide a useful probe for the study of neutrophil chemotactic function and dysfunction.
An image-based skeletal tissue model for the ICRP reference newborn

Hybrid phantoms represent a third generation of computational models of human anatomy needed for dose assessment in both external and internal radiation exposures. Recently, we presented the first whole-body hybrid phantom of the ICRP reference newborn with a skeleton constructed from both non-uniform rational B-spline and polygon-mesh surfaces (Lee et al 2007 Phys. Med. Biol. 52 3309–33). The skeleton in that model included regions of cartilage and fibrous connective tissue, with the remainder given as a homogenous mixture of cortical and trabecular bone, active marrow and miscellaneous skeletal tissues. In the present study, we present a comprehensive skeletal tissue model of the ICRP reference newborn to permit a heterogeneous representation of the skeleton in that hybrid phantom set—both male and female—that explicitly includes a delineation of cortical bone so that marrow shielding effects are correctly modeled for low-energy photons incident upon the newborn skeleton. Data sources for the tissue model were threefold. First, skeletal site-dependent volumes of homogeneous bone were obtained from whole-cadaver CT image analyses. Second, selected newborn bone specimens were acquired at autopsy and subjected to micro-CT image analysis to derive model parameters of the marrow cavity and bone trabecular 3D microarchitecture. Third, data given in ICRP Publications 70 and 89 were selected to match reference values on total skeletal tissue mass. Active marrow distributions were found to be in reasonable agreement with those given previously by the ICRP. However, significant differences were seen in total skeletal and site-specific masses of trabecular and cortical bone between the current and ICRP newborn skeletal tissue models. The latter utilizes an age-independent ratio of 80%/20% cortical and trabecular bone for the reference newborn. In the current study, a ratio closer to 40%/60% is used based upon newborn CT and micro-CT skeletal image analyses. These changes in mineral bone composition may have significant dosimetric implications when considering localized marrow dosimetry for radionuclides that target mineral bone in the newborn child.
Improving the Reliability of Internet Paths with One-hop Source Routing

Recent work has focused on increasing availability in the face of Internet path failures. To date, proposed solutions have relied on complex routing and path-monitoring schemes, trading scalability for availability among a relatively small set of hosts. This paper proposes a simple, scalable approach to recover from Internet path failures. Our contributions are threefold. First, we conduct a broad measurement study of Internet path failures on a collection of 3,153 Internet destinations consisting of popular Web servers, broad-band hosts, and randomly selected nodes. We monitored these destinations from 67 PlanetLab vantage points over a period of seven days, and found availabilities ranging from 99.6% for servers to 94.4% for broadband hosts. When failures do occur, many appear too close to the destination (e.g., last-hop and end-host failures) to be mitigated through alternative routing techniques of any kind. Second, we show that for the failures that can be addressed through routing, a simple, scalable technique, called one-hop source routing, can achieve close to the maximum benefit available with very low overhead. When a path failure occurs, our scheme attempts to recover from it by routing indirectly through a small set of randomly chosen intermediaries. Third, we implemented and deployed a prototype one-hop source routing infrastructure on PlanetLab. Over a three day period, we repeatedly fetched documents from 982 popular Internet Web servers and used one-hop source routing to attempt to route around the failures we observed. Our results show that our prototype successfully recovered from 56% of network failures. However, we also found a large number of server failures that cannot be addressed through alternative routing. Our research demonstrates that one-hop source routing is easy to implement, adds negligible overhead, and achieves close to the maximum benefit available to indirect routing schemes, without the need for path monitoring, history, or a-priori knowledge of any kind.
Asymptotic analysis of full-duplex bidirectional MIMO link with transmitter noise

Bidirectional wireless communication between two multi-antenna terminals that operate in a full-duplex mode is considered. The effects of loopback self-interference and transmit-side noise due to radio front-end imperfections are analyzed in the asymptotic regime where the number of antennas at both terminals grows large. The study compares two transparent mitigation schemes by which conventional spatial multiplexing can operate without being aware of the self-interference issue: spatial-domain null-space projection and time-domain subtractive cancellation. Both schemes eliminate the information-bearing part of the self-interference perfectly, but due to transmitter imperfections, the cancellation approach suffers from residual self-interference. The receive-side null-space projection, on the other hand, suppresses also the transmit-side distortion, but at the cost of reduction in the degrees of freedom available for data reception. The results indicate that suppression becomes preferred when the level of transmit-side noise increases and the receiver does not have instantaneous knowledge about the spatial structure of the self-interference. Exhaustive Monte Carlo simulations also show that the asymptotic analytical results are useful for evaluating the performance of practical not-so-large systems.
Characterization and Regulation of Aquaporin Genes of Sorghum [Sorghum bicolor (L.) Moench] in Response to Waterlogging Stress

Waterlogging is a significant environmental constraint to crop production, and a better understanding of plant responses is critical for the improvement of crop tolerance to waterlogged soils. Aquaporins (AQPs) are a class of channel-forming proteins that play an important role in water transport in plants. This study aimed to examine the regulation of AQP genes under waterlogging stress and to characterize the genetic variability of AQP genes in sorghum (Sorghum bicolor). Transcriptional profiling of AQP genes in response to waterlogging stress in nodal root tips and nodal root basal regions of two tolerant and two sensitive sorghum genotypes at 18 and 96 h after waterlogging stress imposition revealed significant gene-specific pattern with regard to genotype, root tissue sample, and time point. For some tissue sample and time point combinations, PIP2-6, PIP2-7, TIP2-2, TIP4-4, and TIP5-1 expression was differentially regulated in tolerant compared to sensitive genotypes. The differential response of these AQP genes suggests that they may play a tissue specific role in mitigating waterlogging stress. Genetic analysis of sorghum revealed that AQP genes were clustered into the same four subfamilies as in maize (Zea mays) and rice (Oryza sativa) and that residues determining the AQP channel specificity were largely conserved across species. Single nucleotide polymorphism (SNP) data from 50 sorghum accessions were used to build an AQP gene-based phylogeny of the haplotypes. Phylogenetic analysis based on single nucleotide polymorphisms of sorghum AQP genes placed the tolerant and sensitive genotypes used for the expression study in distinct groups. Expression analyses suggested that selected AQPs may play a pivotal role in sorghum tolerance to water logging stress. Further experimentation is needed to verify their role and to leverage phylogenetic analyses and AQP expression data to improve waterlogging tolerance in sorghum.
ROS generation mediates the anti-cancer effects of WZ35 via activating JNK and ER stress apoptotic pathways in gastric cancer

Gastric cancer is one of the leading causes of cancer mortality in the world, and finding novel agents and strategies for the treatment of advanced gastric cancer is of urgent need. Curcumin is a well-known natural product with anti-cancer ability, but is limited by its poor chemical stability. In this study, an analog of curcumin with high chemical stability, WZ35, was designed and evaluated for its anti-cancer effects and underlying mechanisms against human gastric cancer. WZ35 showed much stronger anti-proliferative effects than curcumin, accompanied by dose-dependent induction of cell cycle arrest and apoptosis in gastric cancer cells. Mechanistically, our data showed that WZ35 induced reactive oxygen species (ROS) production, resulting in the activation of both JNK-mitochondrial and ER stress apoptotic pathways and eventually cell apoptosis in SGC-7901 cells. Blockage of ROS production totally reversed WZ35-induced JNK and ER stress activation as well as cancer cell apoptosis. In vivo, WZ35 showed a significant reduction in SGC-7901 xenograft tumor size in a dose-dependent manner. Taken together, this work provides a novel anticancer candidate for the treatment of gastric cancer, and importantly, reveals that increased ROS generation might be an effective strategy in human gastric cancer treatment.
Collagenofibrotic Glomerulonephropathy in a Cynomolgus Macaque (Macaca fascicularis)

Collagenofibrotic glomerulonephropathy (CFGN) is characterized by the deposition of type III collagen within the mesangial matrix and the absence of mesangial cell proliferation. A case of CFGN in a 2.7-year-old female cynomolgus macaque was investigated in the present study. Clinically, the animal was shown to have severe systemic edema along with hypoproteinemia. At necropsy, the kidneys were swollen and pale. The glomerular lesions were characterized by massive diffuse and global accumulation of fibrous materials in the mesangial areas. Neither mesangial cell proliferation nor changes in other organs were found. The fibrous materials were confirmed by the results of immunohistochemical and electron microscopic findings to consist mainly of randomly arranged, curve-shaped, twisted, and entwined type III collagen. This is the first case report of CFGN in nonhuman primates to date.
Testing the independent species’ arrangement assertion made by theories of stochastic geometry of biodiversity

The assertion that the spatial location of different species is independent of each other is fundamental in major ecological theories such as neutral theory that describes a stochastic geometry of biodiversity. However, this assertion has rarely been tested. Here we use techniques of spatial point pattern analysis to conduct a comprehensive test of the independence assertion by analysing data from three large forest plots with different species richness: a species-rich tropical forest at Barro Colorado Island (Panama), a tropical forest in Sinharaja (Sri Lanka), and a temperate forest in Changbaishan (China). We hypothesize that stochastic dilution effects owing to increasing species richness overpower signals of species associations, thereby yielding approximate species independence. Indeed, the proportion of species pairs showing: (i) no significant interspecific association increased with species richness, (ii) segregation decreased with species richness, and (iii) small-scale interspecific interaction decreased with species richness. This suggests that independence may indeed be a good approximation in the limit of very species-rich communities. Our findings are a step towards a better understanding of factors governing species-rich communities and we propose a hypothesis to explain why species placement in species-rich communities approximates independence.
A 5-year prospective clinical study of Neobiotech implants for partially edentulous patients

cc 2017 The Korean Academy of Prosthodontics This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. *Corresponding Author: Jeong-Yol Lee Department of Prosthodontics, Institute for Clinical Dental Research, Korea University Medical Center, Korea University, 148 Gurodong-ro, Guro-gu, Seoul 08308, Republic of Korea +82 (0)2 2626 1922: e-mail, wddc@korea.ac. kr Article history: Received May 10, 2017 / Last Revision May 25, 2017 / Accepted June 8, 2017 Introduction