Miracle-dz/UniFAR-FTUs huggingface dataset:
Bringing Change-of-Shift Report to the Bedside: A Patient- and Family-Centered Approach

Change-of-shift report is the time when responsibility and accountability for the care of a patient is transferred from one nurse to another. The communication that ensues during this process is linked to both patient safety and continuity of care giving. While many nurses already recognize the value of bringing report to the patient's bedside and have practiced in this manner, this remains relatively uncommon. Typically, nurse change-of-shift report has occurred at a nurses’ station, conference room, or hallway and may be face to face, audio-taped, recorded on a telephone service, or in a written format. When report is given away from the bedside, the opportunity to visualize the patient and include the patient and family in an exchange of information and care planning is lost. Yet, patients and families, also stewards of patient safety, are given an opportunity to hear and participate in the exchange of information when report is brought to the bedside. Welcoming patients and families into the report process may be a new and challenging process for nursing staff.
Bacterial diversity in relatively pristine and anthropogenically-influenced mangrove ecosystems (Goa, India)

To appreciate differences in benthic bacterial community composition at the relatively pristine Tuvem and the anthropogenically-influenced Divar mangrove ecosystems in Goa, India, parallel tag sequencing of the V6 region of 16S rDNA was carried out. We hypothesize that availability of extraneously-derived anthropogenic substrates could act as a stimulatant but not a deterrent to promote higher bacterial diversity at Divar. Our observations revealed that the phylum Proteobacteria was dominant at both locations comprising 43–46% of total tags. The Tuvem ecosystem was characterized by an abundance of members belonging to the class Deltaproteobacteria (21%), ~ 2100 phylotypes and 1561 operational taxonomic units (OTUs) sharing > 97% similarity. At Divar, the Gammaproteobacteria were ~ 2× higher (17%) than at Tuvem. A more diverse bacterial community with > 3300 phylotypes and > 2000 OTUs mostly belonging to Gammaproteobacteria and a significantly higher DNT (n = 9, p < 0.001, df = 1) were recorded at Divar. These findings suggest that the quantity and quality of pollutants at Divar are perhaps still at a level to maintain high diversity. Using this technique we could show higher diversity at Divar with the possibility of Gammaproteobacteria contributing to modulating excess nitrate.
Trapline foraging by bumblebees: I. Persistence of flight-path geometry

By setting out arrays of potted plants of Penstemon strictus, I tested whether freely foraging bumblebee (Bombus spp.) workers would establish regular foraging routes that reflected the geometry of the array. They did, passing through an asymmetrical array in a pattern that minimized interplant flight distances. After the array was changed to a symmetrical pattern, however, the experienced bees continued to show their previous asymmetrical flight patterns. New bees without experience on the asymmetrical array showed no asymmetry on the symmetrical array. I term this persistence of flight-path geometry "trapline holdover," and discuss its implications for the study of animals' learning and foraging behavior.
Contract-Based Requirement Modularization via Synthesis of Correct Decompositions

In distributed development of modern systems, contracts play a vital role in ensuring interoperability of components and adherence to specifications. It is therefore often desirable to verify the satisfaction of an overall property represented as a contract, given the satisfaction of smaller properties also represented as contracts. When the verification result is negative, designers must face the issue of refining the subproperties and components. This is an instance of the classical synthesis problems: “can we construct a model that satisfies some given specification? ” In this work, we propose two strategies enabling designers to synthesize or refine a set of contracts so that their composition satisfies a given contract. We develop a generic algebraic method and show how it can be applied in different contract models to support top-down component-based development of distributed systems.
Life Expectancy and Mother-Baby Interventions Evidence from A Historical Trial # 504

The working papers published in the Series constitute work in progress circulated to stimulate discussion and critical comments. Views expressed represent exclusively the authors' own opinions and do not necessarily refl ect those of the editors. Die Deutsche Bibliothek verzeichnet diese Publikation in der deutschen National-bibliografi e; detaillierte bibliografi sche Daten sind im Internet über: Abstract This paper investigates the potential of an infant intervention to improve life expectancy, contributing to emerging interest in the early life origins of chronic disease. We analyse a pioneering program trialled in Sweden in the 1930s, which provided information, support and monitoring of infant care. Using birth certicate data from parish records matched to death registers, we estimate that the average duration of program exposure in infancy led to a 1.54% point decline in the risk of infant death (23% of baseline risk) and a 2.37% decline in the risk of dying by age 75 (6.5% of baseline risk).
Relationship between renal volume growth and renal function in autosomal dominant polycystic kidney disease: a longitudinal study.

In autosomal dominant polycystic kidney disease (ADPKD), renal function remains normal for many years into adult life while cysts form and expand progressively, starting in childhood. The longitudinal relationships between renal volume growth, hypertension, and renal function loss have not been examined in detail. At the University of Colorado (Denver, CO), 229 adult subjects with ADPKD participated in a longitudinal study from 1985 to 2001. Sequential ultrasound examinations were performed at a mean interval of 7.8 +/- 3.1 years (range, 2.6 to 15.1 years). Renal volume was calculated using a standard formula for a modified ellipsoid. The Modified Diet in Renal Disease equation was used to calculate glomerular filtration rate (GFR). The mean annual increase in renal volume was 46 +/- 55 cm3, and mean annual decline in GFR was 2.4 +/- 2.8 mL/min/1.73 m2. Men had faster renal growth, more severe hypertension, and a faster decline in GFR than women of similar ages. Multiple linear regression showed a significant relationship between rate of change in GFR and renal volume growth rate, initial renal volume, proteinuria, and age at entry. Correlational analysis showed a significant correlation between GFR and renal volume over time (R = -0.53) and between follow-up renal volume and follow-up GFR (R = -0.50) for both men and women. We conclude that renal volume and rate of renal volume growth may be useful markers for disease progression in early stages of ADPKD when GFR is preserved.
Money-Back Guarantees: Helping the Low-Quality Retailer

Existing literature, based on signaling theory, suggests that money-back guarantees (MBGs) will be utilized by high-quality firms, where high quality is defined as a low likelihood of product return. However, in today's world, MBGs are ubiquitous among major retailers, even when the likelihood of product return varies greatly between them. To understand this phenomenon, we explore a competitive environment between high-and low-quality retailers where consumers are fully informed and risk neutral, and retailers realize a salvage value for returned products. When MBGs are profitable, under continuous demand it is Nash equilibrium for both retailers to offer MBGs, and the low-quality retailer gains while the high-quality retailer loses relative to when MBGs are not offered. In contrast, if demand is lumpy, retailers can act monopolistically over their respective market segments, allowing both retailers to gain from MBGs, although the low-quality retailer still gains more. This paper was accepted by J. Miguel Villas-Boas, marketing.
Physiological changes in eucalyptus hybrids under different irrigation regimes

With the expansion of the cultivation of eucalyptus into areas with limited water resources, recommending genotypes which are tolerant to low water availability is important in order to maximize productivity under such conditions. The aim of this work therefore was to evaluate five hybrids of Eucalyptus grandis x E. urophylla (H1 to H5) subjected to four irrigation regimes in the greenhouse: daily (IR1), every two days (IR2), every four days (IR4) and every six days (IR6). The following characteristics were evaluated: photosynthetic rate (A), transpiration (E), stomatal conductance (gs), leaf water potential (Ψw), leaf relative water content, photochemical efficiency and chlorophyll content index. Evaluations of A, gs and E were carried out on two occasions: 1 - under stress, at the end of the interval between irrigations for each treatment; and 2 - in recovery, 48 h after irrigation for all plants in the experiment. On average, there was reduction of 25 and 40% in A values, 40 and 55% in gs, 15 and 22% in E, and 96 and 103% in Ψw respectively in those plants under regimes IR4 and IR6, compared to under IR1. Stomatal conductance had only partially recovered 48 h after irrigation, and due to being more sensitive, its changes are a good indication of water stress. Hybrid H3 is the most tolerant and H5 the most sensitive to a reduction in water availability in soil.
Improving text compression ratios with the Burrows-Wheeler transform

[Summary form only given]. In this paper we describe several methods that can be used to improve the compression ratio of compression algorithms based an the Burrows-Wheeler transform, as implemented in 'bzip2', when used in combination with English language text files. We first briefly describe the Burrows-Wheeler transform and some of its strengths and weaknesses. We then describe our implementations of enhancements and test results. All of our enhancements are implemented in the form of pre- and postprocessing algorithms that are used in addition to the transform. The use of our algorithms has resulted in improvements in compression ratios of up to 20% over bzip2. The first method involves changing the order of characters in the character set encoding of the input file. We describe different ways to improve the encoding order. A more elaborate method involves minimizing the contextual differences between subsequent codes, using an optimized encoding order obtained by solving a traveling salesman problem. In the second method we replaced frequently occurring bigrams by single unused character codes, in order to better utilize the available character encoding space. In most cases this method did not result in improvements in the compression ratio. The final method is a refinement of the method we presented in "Preprocessing Text to Improve Compression Ratios", DCC 98. A common English language dictionary is used to preprocess input text and replace English words with encodings that are more easily compressible by bzip2. In this paper we describe optimizations to our original method to further improve the compression ratio. We also show practical ways to use our method on wide-area networks like the Internet, and easy ways to solve the problem of dictionary distribution and caching.
Inositol trisphosphate levels in cells expressing wild-type and mutant polyomavirus middle T antigens: evidence for activation of phospholipase C via activation of pp60c-src

The transforming protein of polyomavirus, middle T (mT), forms a complex with two cellular enzymes: the protein tyrosine kinase pp60c-src and a phosphatidylinositol (PtdIns) 3-kinase. A mutant virus, Py1178T, encodes an mT protein which associates with and activates pp60c-src to the same extent as the wild type but fails to associate with PtdIns 3-kinase. To investigate relationships between activation of pp60c-src, association of PtdIns 3-kinase, and cellular levels of the second messenger inositol 1,4,5-trisphosphate (InsP3), we examined the effects of wild-type and mutant mT proteins on inositol metabolism in rat and mouse fibroblasts. Expression of either wild-type or 1178T mT caused a 300 to 500% increase in the InsP3 level. Cells transformed by Rous sarcoma virus also showed similar increases in InsP3 levels. Mutant mT proteins which failed to activate pp60c-src (NG59 and 1387T) had no effect on InsP3 levels. Pulse-chase experiments with [3H]inositol showed that the turnover of phosphoinositides was increased in cells transformed by either wild-type polyomavirus or Py1178T as compared with the normal parent cell line. The turnover of inositol phosphates was unchanged upon transformation. These data indicate that cells expressing either wild-type or mutant 1178T mT or pp60v-src exhibit elevated levels of InsP3 because of activation of phospholipase C. This activation appears to depend, directly or indirectly, upon activation of pp60src protein kinase activity. Activation of pp60c-src and elevation of InsP3 content are not sufficient for full transformation. Full transformation also requires the association of mT-pp60c-src complexes with PtdIns 3-kinase.
Dopaminergic Modulation of Decision Making and Subjective Well-Being

The neuromodulator dopamine has a well established role in reporting appetitive prediction errors that are widely considered in terms of learning. However, across a wide variety of contexts, both phasic and tonic aspects of dopamine are likely to exert more immediate effects that have been less well characterized. Of particular interest is dopamine's influence on economic risk taking and on subjective well-being, a quantity known to be substantially affected by prediction errors resulting from the outcomes of risky choices. By boosting dopamine levels using levodopa (l-DOPA) as human subjects made economic decisions and repeatedly reported their momentary happiness, we show here an effect on both choices and happiness. Boosting dopamine levels increased the number of risky options chosen in trials involving potential gains but not trials involving potential losses. This effect could be better captured as increased Pavlovian approach in an approach–avoidance decision model than as a change in risk preferences within an established prospect theory model. Boosting dopamine also increased happiness resulting from some rewards. Our findings thus identify specific novel influences of dopamine on decision making and emotion that are distinct from its established role in learning.
Gain Control in CA1 Pyramidal Cells Using Changes in Somatic Conductance

Gain modulation is an important feature of neural activity. Previous work has focused on the ability of background synaptic noise to modulate the slope (i.e., gain) of the frequency–current (f–I) relationship in neurons. To date, demonstrations of gain control that are independent of synaptic noise have been limited. We investigated the effects of increasing somatic conductance in the form of tonic inhibition on the initial and steady-state f–I relationship of CA1 pyramidal cells. We find that increasing membrane conductance reduces the gain of the steady-state f–I relationship through a graded increase in the magnitude of spike frequency adaptation. Increased adaptation arises through a conductance-induced depolarization of spike voltage threshold. Thus, by increasing the magnitude of spike frequency adaptation, added conductance can reduce the gain of the steady-state f–I relationship in the absence of random background membrane fluctuations.
Jab1 Mediates Cytoplasmic Localization and Degradation of West Nile Virus Capsid Protein*

The clinical manifestations of West Nile virus (WNV), a member of the Flavivirus family, include febrile illness, sporadic encephalitis, and paralysis. The capsid (Cp) of WNV is thought to participate in these processes by inducing apoptosis through mitochondrial dysfunction and activation of caspase-9 and caspase-3. To further identify the molecular mechanism of the WNV capsid protein (WNVCp), yeast two-hybrid assays were employed using WNV-Cp as bait. Jab1, the fifth subunit of the COP9 signalosome, was subsequently identified as a molecule that interacts with WNVCp. Immunoprecipitation and glutathione S-transferase pulldown assays confirmed that direct interaction could occur between WNVCp and Jab1. Immunofluorescence microscopy demonstrated that the overexpressed WNVCp, which localized to the nucleolus, was translocated to the cytoplasm upon its co-expression with Jab1. When treated with leptomycin B, Jab1-facilitated nuclear exclusion of WNVCp was prevented, which indicated that the CRM1 complex is required for Jab1-facilitated nuclear export of WNVCp. Moreover, Jab1 promoted the degradation of WNVCp in a proteasome-dependent way. Consistent with this, WNVCp-mediated cell cycle arrest at the G2 phase in H1299 was prevented by exogenous Jab1. Finally, an analysis of WNVCp deletion mutants indicated that the first 15 amino acids were required for interaction with Jab1. Furthermore, the double-point mutant of the WNVCp, P5A/P8A, was incapable of binding to Jab1. These results indicate that Jab1 has a potential protective effect against pathogenic WNVCp and might provide a novel target site for the treatment of disease caused by WNV.
Neuronal firing in the inferotemporal cortex of the monkey in a visual memory task

The objective of this study was to elucidate the functional role of neurons in the inferotemporal cortex of the primate. Single unit activity was recorded with microelectrodes in monkeys performing a visual delayed matching-to-sample task. On each trial, the animal was exposed briefly to a color - the sample - and, after a period of delay, had to select the same color among two or four colors simultaneously presented. Thus, correct performance of the task required perception, retention, and recognition of the sample color for every trial. A large number of inferotemporal units were seen to react to the stimuli with changes of firing frequency. Many units showed color-dependent reactions, suggesting their involvement in perception and discrimination of colors. A substantial contingent of cells showed increased, sustained, and in some cases, color-dependent discharge during the delay which was not necessarily preceded or succeeded by firing changes in sample or match periods. It is proposed that those cells were engaged in temporary retention of the sample stimulus. Since most of the inferotemporal units examined showed firing changes in more than one period of a trial, they appeared to be involved in more than one of the operations required by the task. Thus, the data do not support a clear-cut topographic separation of visual functions within the inferotmeporal cortex. However, neurons that appear to participate in visual memory, either exclusively or in addition to other functions, are concentrated in the cortex of the lower banks of the superior temporal sulcus.
Individualisation, assumptions about the existence of an adult worker model and the shift towards contractualism

While the family and its role continues to be a key topic in social and government policy, much of the literature is concerned with describing the dramatic changes that are taking place. By contrast, this book directly addresses the social processes responsible for these changes - how social policy interacts with what families actually do. With contributions from the UK, and North America, Analysing Families provides the framework within which to understand an increasingly important element in social policy.
Effect of compost enriched with N and L-tryptophan on soil and maize

Composting provides an excellent way to manage the huge volume of organic waste and convert it into a useful soil amendment. The effectiveness of composted organic waste can be further improved by enriching and blending it with nutrients and biologically active substances. The resulting value-added composts can be used at substantially low rates such as a few hundred kg per ha compared with conventional use of organic wastes in tons per ha. This approach could have practical significance in reducing the use of chemical fertilizer for sustainable agriculture and the environment. L-tryptophan is a precursor of the growth hormone indole acetic acid and is known to stimulate plant growth at extremely low concentrations. Here, we studied the effect of composted fruit and vegetable wastes, enriched with N at 133 g kg−1 compost, with or without L-tryptophan at 10 mg kg−1 compost, on soil and maize crops. The enriched compost was applied at 300 kg ha−1 to a sandy clay loam soil either by mixing with the top 15-cm soil layer in pots or as a band placement along the maize plants grown in the field. The compost was applied alone and in combination with 40 or 80 kg ha−1 urea N and compared with a treatment containing 160 kg N ha−1, a full dose of N fertilizer alone, while P and K fertilizers were applied in all the treatments. Our results show that application of the enriched compost to soil increased aggregate stability by up to 24.8% and water retention by up to 43.1% compared with untreated control. A gradual increase in the concentration of indole acetic acid in compost, ranging from 1.02 to 3.34 mg kg−1, was observed when compost was treated with its precursor L-tryptophan. The results of pot and field experiments revealed that compost enriched with N and L-tryptophan in the presence of 80 kg N fertilizer significantly increased cob and grain yields, by up to 19.8 and 21.4%, respectively, compared with a full dose of N fertilizer. These findings suggest that enrichment of composted organic wastes with N and L-tryptophan can change them into a value-added organic product that could be used as a soil amendment at rates as low as 300 kg ha−1 to increase crop production on a sustainable basis.
A Computational Analysis of the Function of Three Inhibitory Cell Types in Contextual Visual Processing

Most cortical inhibitory cell types exclusively express one of three genes, parvalbumin, somatostatin and 5HT3a. We conjecture that these three inhibitory neuron types possess distinct roles in visual contextual processing based on two observations. First, they have distinctive synaptic sources and targets over different spatial extents and from different areas. Second, the visual responses of cortical neurons are affected not only by local cues, but also by visual context. We use modeling to relate structural information to function in primary visual cortex (V1) of the mouse, and investigate their role in contextual visual processing. Our findings are three-fold. First, the inhibition mediated by parvalbumin positive (PV) cells mediates local processing and could underlie their role in boundary detection. Second, the inhibition mediated by somatostatin-positive (SST) cells facilitates longer range spatial competition among receptive fields. Third, non-specific top-down modulation to interneurons expressing vasoactive intestinal polypeptide (VIP), a subclass of 5HT3a neurons, can selectively enhance V1 responses.