Miracle-dz/UniFAR-FTUs huggingface dataset:
Uranium-series isotope and thermal constraints on the rate and depth of silicic magma genesis

Abstract Uranium-series isotopes provide important constraints on the timescale of magma differentiation and this can be used to identify where in the crust and silicic magmas acquire their geochemical characteristics. Timescales of differentiation can be inferred from the observed co-variations of U-series disequilibria with differentiation indexes. When crustal assimilation of secular equilibrium material is involved, inferred timescales will generally decrease. In turn, they will increase if periodical recharge (>20 wt% relative volume) of the magma body occurs. If crustal assimilation and magma recharge occur concurrently, inferred timescales for differentiation can be similar to that of closed system differentiation. We illustrate the approach with data from Mount St Helens which suggest that dacitic compositions are produced in c. 2000 years. Combining this with recent evidence for an important role for amphibole fractionation suggests that differentiation of a c. 10 km3 magma body at this volcanic centre occurs at 8–10 km depth in the crust.
Creative Requirement

We identify the creative requirement of a job as a neglected predictor of employee creativity and propose that it may account for relationships between traditional work factors and creativity. As such, it may represent a more effective means of increasing creativity than changes in job design. Using structural equation modeling, we tested this model against four competing models using a sample of 1,083 health service employees. Creative requirement was found to account for much of the variance by fully mediating the effects of supportive leadership and role requirements and partially mediating those of empowerment and time demands. We conclude that creative requirement is an important proximal determinant of employee creativity and a potentially significant intervention.
Different Neuronal Computations of Spatial Working Memory for Multiple Locations within versus across Visual Hemifields

Spatial working memory is one of the most studied cognitive functions, serving as a model system to decipher computational principles of the brain. Although neuronal mechanisms for remembering a single location have been well elucidated, little is known about memory for multiple locations. Here, we examined the activities of prefrontal neurons during monkeys remembered positions of one or two visual cue(s). When the two cues were presented across the left and right visual fields, neurons exhibited a comparable response to the activity for the preferred cue presented alone. When the two cues were presented within the same hemifield, neurons exhibited an intermediate response between those to the individual cues. Subsequent computer simulations predicted a lower signal-to-noise ratio in the latter condition, which was further verified by behavioral experiments. Considering the separation of contralateral and ipsilateral visual processing, the lateral inhibition in local circuits might implicitly determine different neuronal computations and memory capacities for bilateral and unilateral displays.
BRCT Domain-containing Protein TopBP1 Functions in DNA Replication and Damage Response*

Topoisomerase IIβ-binding protein (TopBP1), a human protein with eight BRCT domains, is similar toSaccharomyces cerevisiae Dpb11 andSchizosaccharomyces pombe Cut5 checkpoint proteins and closely related to Drosophila Mus101. We show that human TopBP1 is required for DNA replication and that it interacts with DNA polymerase ε. In S phase TopBP1 colocalizes with Brca1 to foci that do not represent sites of ongoing DNA replication. Inhibition of DNA synthesis leads to relocalization of TopBP1 together with Brca1 to replication forks, suggesting a role in rescue of stalled forks. DNA damage induces formation of distinct TopBP1 foci that colocalize with Brca1 in S phase, but not in G1 phase. We also show that TopBP1 interacts with the checkpoint protein hRad9. Thus, these results implicate TopBP1 in replication and checkpoint functions.
Smad4-dependent TGF-β Signaling Suppresses RON Receptor Tyrosine Kinase-dependent Motility and Invasion of Pancreatic Cancer Cells*

Transforming growth factorβ (TGF-β) signals through Smad-dependent and Smad-independent pathways. However, Smad signaling is altered by allelic deletion or intragenic mutation of the Smad4 gene in more than half of pancreatic ductal adenocarcinomas. We show here that loss of Smad4-dependent signaling leads to aberrant expression of RON, a phosphotyrosine kinase receptor, and that signaling by RON cooperates with Smad4-independent TGF-β signaling to promote cell motility and invasion. Restoring Smad4 expression in a pancreatic ductal adenocarcinoma cell line that is deficient in Smad4 repressed RON expression. Conversely, small interference RNA knock down of Smad4 or blocking TGF-β signaling with a TGF-β type I receptor kinase inhibitor in Smad4-intact cell lines induced RON expression. TGF-β-induced motility and invasion were inhibited in cells that express Smad4 and that have low levels of RON compared with isogenically matched cells that were deficient in Smad4. Furthermore, knocking down RON expression in Smad4-deficient cells suppressed TGF-β-mediated motility and invasion. We further determined that Smad4-dependent signaling regulated RON expression at the transcriptional level by real-time reverse transcription PCR and RON promoter luciferase reporter assays. Functional inactivation by site-directed mutations of two Smad binding sites on the RON promoter inhibited TGF-β-mediated repression of RON promoter activity. These studies indicate that loss of Smad4 contributes to aberrant RON expression and that cross-talk of Smad4-independent TGF-β signaling and the RON pathway promotes an invasive phenotype.
Measurement of Trailing EDGE Noise Using Directional Array and Coherent Output Power Methods

The use of a directional array of microphones for the measurement of trailing edge (TE) noise is described. The capabilities of this method are evaluated via measurements of TE noise from a NACA 63-215 airfoil model and from a cylindrical rod. This TE noise measurement approach is compared to one that is based on the cross spectral analysis of output signals from a pair of microphones (COP method). Advantages and limitations of both methods are examined. It is shown that the microphone array can accurately measures TE noise and captures its two-dimensional characteristic over a large frequency range for any TE configuration as long as noise contamination from extraneous sources is within bounds. The COP method is shown to also accurately measure TE noise but over a more limited frequency range that narrows for increased TE thickness. Finally, the applicability and generality of an airfoil self-noise prediction method was evaluated via comparison to the experimental data obtained using the COP and array measurement methods. The predicted and experimental results are shown to agree over large frequency ranges.
Can education affect pro‐social behavior?: Cops, economists and humanists in social dilemmas

Purpose - The purpose of this paper is to examine whether education and training affect pro-social behavior. Economics students are often accused of being less pro-social. The explanations given are that less pro-social people choose to study economics or that economics studies indoctrinate students to selfish behavior. The paper experimentally tests these postulations. Design/methodology/approach - The paper uses the prisoner's dilemma game and stag hunt game to study cooperation across different groups of students. Findings - The experiment supports neither of the postulations: economics students would be indoctrinated or less pro-social people choose to study economics. However, the study shows that police cadets, who go through an education where teamwork and cooperation is promoted, become more cooperative and pro-social after their completed education. Originality/value - In contrast to earlier studies, this paper does not simply study economics students, but also examines if students in educational programs that promote loyalty and cooperation and encourage teamwork are more pro-social than other students.
A modification in the tube guide to facilitate retrograde intubation: A prospective, randomised trial

Background: The technique of anterograde over a retrograde guide is considered to be more reliable and preferable in comparison to only retrograde one, for improving the success rate of retrograde intubation. As the prior technique requires a lengthy guidewire to negotiate the whole channel of a tube guide, we designed a side eye at one end of tube guide, which obviated the above requirement while maintaining the integrity of the whole channel assembly. The efficacy of this modified technique was compared with the conventional one for retrograde intubation procedure. Methods: In a prospective, randomised fashion, 98 cases posted for surgery of carcinoma buccal mucosa were included in this trial. These cases were randomised to the conventional (Group I) or the modified technique (Group II) for retrograde intubation. Intubation time (first attempt), total number of successful intubations, cause of failures and any associated side effects were recorded and compared between the groups. Results: The total number of successful intubations were significantly higher in group II (95.83%, 46/48 cases) as compared to group I (66.66%, 31/48 cases) (P<0.001). Mean intubation time was 118±22 second in group I versus 124±26 second in group II (P=0.39). The side effects did not differ significantly between the groups. Conclusions: Improvising the tube guide resulted in a significant rise in the number of successful intubations through a modified retrograde intubation technique, with no side effects. This should encourage the use of retrograde intubation technique as a first option for difficult airway management.
Traumatic Relationships and Serious Mental Disorders

List of Tables and Figures. About the Author. Foreword--Peter Fonagy. Preface. DEVELOPMENTAL FOUNDATIONS. A Developmental Approach to Trauma. Trauma in Attachment Relationships. Attachment, Relationships, and Reenactment. The Traumatized Self. TRAUMA--RELATED DISORDERS. PTSD and Traumatic Memories. Trauma as Chronic Physical Illness. Dissociative Detachment and Compartmentalization. Substance Abuse, Eating Disorders, and Self--Harm. Post--Traumatic Depression. Post--Traumatic Personality Disorders. TREATMENT AND LONG--TERM MANAGEMENT. Containing Trauma. Narrating Trauma. Psychoeducational Approaches. Therapists At Risk. References. Index.
Protein Loop Modeling Using a New Hybrid Energy Function and Its Application to Modeling in Inaccurate Structural Environments

Protein loop modeling is a tool for predicting protein local structures of particular interest, providing opportunities for applications involving protein structure prediction and de novo protein design. Until recently, the majority of loop modeling methods have been developed and tested by reconstructing loops in frameworks of experimentally resolved structures. In many practical applications, however, the protein loops to be modeled are located in inaccurate structural environments. These include loops in model structures, low-resolution experimental structures, or experimental structures of different functional forms. Accordingly, discrepancies in the accuracy of the structural environment assumed in development of the method and that in practical applications present additional challenges to modern loop modeling methods. This study demonstrates a new strategy for employing a hybrid energy function combining physics-based and knowledge-based components to help tackle this challenge. The hybrid energy function is designed to combine the strengths of each energy component, simultaneously maintaining accurate loop structure prediction in a high-resolution framework structure and tolerating minor environmental errors in low-resolution structures. A loop modeling method based on global optimization of this new energy function is tested on loop targets situated in different levels of environmental errors, ranging from experimental structures to structures perturbed in backbone as well as side chains and template-based model structures. The new method performs comparably to force field-based approaches in loop reconstruction in crystal structures and better in loop prediction in inaccurate framework structures. This result suggests that higher-accuracy predictions would be possible for a broader range of applications. The web server for this method is available at http://galaxy.seoklab. org/loop with the PS2 option for the scoring function.
A Computational Approach for Full Nonparametric Bayesian Inference Under Dirichlet Process Mixture Models

Widely used parametric generalized linear models are, unfortunately, a somewhat limited class of specifications. Nonparametric aspects are often introduced to enrich this class, resulting in semiparametric models. Focusing on single or k-sample problems, many classical nonparametric approaches are limited to hypothesis testing. Those that allow estimation are limited to certain functionals of the underlying distributions. Moreover, the associated inference often relies upon asymptotics when nonparametric specifications are often most appealing for smaller sample sizes. Bayesian nonparametric approaches avoid asymptotics but have, to date, been limited in the range of inference. Working with Dirichlet process priors, we overcome the limitations of existing simulation-based model fitting approaches which yield inference that is confined to posterior moments of linear functionals of the population distribution. This article provides a computational approach to obtain the entire posterior distribution for more general functionals. We illustrate with three applications: investigation of extreme value distributions associated with a single population, comparison of medians in a k-sample problem, and comparison of survival times from different populations under fairly heavy censoring.
The greatest magic of Harry Potter: Reducing prejudice

Recent research shows that extended contact via story reading is a powerful strategy to improve out-group attitudes. We conducted three studies to test whether extended contact through reading the popular best-selling books of Harry Potter improves attitudes toward stigmatized groups (immigrants, homosexuals, refugees). Results from one experimental intervention with elementary school children and from two cross-sectional studies with high school and university students (in Italy and United Kingdom) supported our main hypothesis. Identification with the main character (i.e., Harry Potter) and disidentification from the negative character (i.e., Voldemort) moderated the effect. Perspective taking emerged as the process allowing attitude improvement. Theoretical and practical implications of the findings are discussed in the context of extended intergroup contact and social cognitive theory.
Therapeutic potential of oncolytic Newcastle disease virus: a critical review

Newcastle disease virus (NDV) features a natural preference for replication in many tumor cells compared with normal cells. The observed antitumor effect of NDV appears to be a result of both selective killing of tumor cells and induction of immune responses. Genetic manipulations to change viral tropism and arming the virus with genes encoding for cytokines improved the oncolytic capacity of NDV. Several intracellular proteins in tumor cells, including antiapoptotic proteins (Livin) and oncogenic proteins (H-Ras), are relevant for the oncolytic activity of NDV. Defects in the interferon system, found in some tumor cells, also contribute to the oncolytic selectivity of NDV. Notwithstanding, NDV displays effective oncolytic activity in many tumor types, despite having intact interferon signaling. Taken together, several cellular systems appear to dictate the selective oncolytic activity of NDV. Some barriers, such as neutralizing antibodies elicited during NDV treatment and the extracellular matrix in tumor tissue appear to interfere with spread of NDV and reduce oncolysis. To further understand the oncolytic activity of NDV, we compared two NDV strains, ie, an attenuated virus (NDV-HUJ) and a pathogenic virus (NDV-MTH-68/H). Significant differences in amino acid sequence were noted in several viral proteins, including the fusion precursor (F0) glycoprotein, an important determinant of replication and pathogenicity. However, no difference in the oncolytic activity of the two strains was noted using human tumor tissues maintained as organ cultures or in mouse tumor models. To optimize virotherapy in clinical trials, we describe here a unique organ culture methodology, using a biopsy taken from a patient’s tumor before treatment for ex vivo infection with NDV to determine the oncolytic potential on an individual basis. In conclusion, oncolytic NDV is an excellent candidate for cancer therapy, but more knowledge is needed to ensure success in clinical trials.
A Simple Homotopy Proximal Mapping for Compressive Sensing

In this paper, we present a novel yet simple homotopy proximal mapping algorithm for compressive sensing. The algorithm adopts a simple proximal mapping of the $\ell_1$ norm at each iteration and gradually reduces the regularization parameter for the $\ell_1$ norm. We prove a global linear convergence of the proposed homotopy proximal mapping (HPM) algorithm for solving compressive sensing under three different settings (i) sparse signal recovery under noiseless measurements, (ii) sparse signal recovery under noisy measurements, and (iii) nearly-sparse signal recovery under sub-gaussian noisy measurements. In particular, we show that when the measurement matrix satisfies Restricted Isometric Properties (RIP), our theoretical results in settings (i) and (ii) almost recover the best condition on the RIP constants for compressive sensing. In addition, in setting (iii), our results for sparse signal recovery are better than the previous results, and furthermore our analysis explicitly exhibits that more observations lead to not only more accurate recovery but also faster convergence. Compared with previous studies on linear convergence for sparse signal recovery, our algorithm is simple and efficient, and our results are better and provide more insights. Finally our empirical studies provide further support for the proposed homotopy proximal mapping algorithm and verify the theoretical results.
Heterogeneity of capsid proteins of echovirus type 25 wild-type strain and prototype strain, studied by using sodium dodecyl sulfate-polyacrylamide gel electrophoresis and immunoblotting

Sodium dodecyl sulfate-polyacrylamide gel electrophoresis and immunoblotting were used to compare the capsid proteins of 19 antigenic variants of echovirus type 25 wild-type strains isolated in France between 1976 and 1987 with those of the prototype JV-4 reference strain isolated in 1957. Immunoblots were developed by using polyclonal sera from rabbits and mice immunized with the reference strain. Immunoblotting patterns revealed reactivity only against viral protein VP1 for sera from both animals. Comparative immunoblotting patterns showed differences in the electrophoretic mobilities of viral protein VP1, especially for the Montpellier 76.1262 wild-type strain. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis analysis of [35S]methioinine-labeled viral polypeptides revealed that the two variant strains, Montpellier 76.1262 and Thionville 86.222, exhibited significant and reproducible shifts in the relative mobilities of VP1 and VP3 and, to a lesser extent, in those of VP0 and VP2. The relative mobility of VP4 seemed very similar for the JV-4 reference strain and the two variants. Interestingly, the structural differences in VP1 and VP3 of Montpellier 76.1262 were not correlated with the pattern of neutralization by monoclonal antibodies, unlike in our previous study, in which this strain differed from the prototype strain in only two epitopes. We concluded that, in addition to the heterogeneity of their biological and antigenic properties that we observed previously, echovirus type 25 wild-type strains may exhibit differences in their structural proteins.
Differences in sedative susceptibility between types of depression. Clinical and neurophysiological significance.

IN 1956 Shagass et al,1reported that psychotic depressed patients differed significantly from neurotic depressed patients in the amount of sodium amobarbital necessary to produce a specific end point of sedation. This end point was characterized by the onset of slurred speech as well as by certain specific changes appearing in the EEG frontal fast activity. Unfortunately, although this finding was later confirmed by Boudreau2and Nymgaard,3other authors who tried to utilize the Shagass technique reported considerable difficulty in determining the sedation threshold point by the speech and/or the EEG criteria.4-7 The theoretical as well as the clinical importance of a difference in sedative susceptibility between types of depression motivated us to the further investigation of this problem. As objective indices of the sedation induced by the progressive intravenous administration of sodium thiopental,
GRADIENT DESCENT AND FAST ARTIFICIAL TIME INTEGRATION

The integration to steady state of many initial value ODEs and PDEs using the forward Euler method can alternatively be considered as gradient descent for an associated minimization prob- lem. Greedy algorithms such as steepest descent for determining the step size are as slow to reach steady state as is forward Euler integration with the best uniform step size. But other, much faster methods using bolder step size selection exist. Various alternatives are investigated from both theo- retical and practical points of view. The steepest descent method is also known for the regularizing or smoothing effect that the first few steps have for certain inverse problems, amounting to a finite time regularization. We further investigate the retention of this property using the faster gradient descent variants in the context of two applications. When the combination of regularization and accuracy demands more than a dozen or so steepest descent steps, the alternatives offer an advantage, even though (indeed because) the absolute stability limit of forward Euler is carefully yet severely violated.
A General Model for Estimating the Laminated Steel Losses Under PWM Voltage Supply

The new model is based on a modified Steinmetz equation and employs a hysteresis-loss multiplicative coefficient and a combined coefficient for eddy-current and excess losses, both coefficients being variable with induction and frequency. The material model coefficients are first identified through multifrequency tests with sine-wave excitation. The iron-loss increase due to pulsewidth-modulation supply is estimated using global waveform parameters of the nonsinusoidal voltage. The study includes three different grades of non-grain-oriented electric steel. The data cover a wide range of fundamental frequency from 10 to 600 Hz and induction from 0.05 to 2 T. The errors of the computational model are small at relatively low fundamental frequency and increase thereafter. The main advantages of the model are its simplicity of use and minimal data requirements.