Miracle-dz/UniFAR-FTUs huggingface dataset:
Sundarban Honey Confers Protection against Isoproterenol-Induced Myocardial Infarction in Wistar Rats

The present study was designed to investigate the cardioprotective effects of Sundarban honey (SH) in rats with isoproterenol- (ISO-) induced myocardial infarction. Adult male Wistar Albino rats were pretreated with Sundarban honey (5 g/kg) daily for a period of 6 weeks. After the treatment period, ISO (85 mg/kg) was subcutaneously injected into the rats at 24 h intervals for 2 days. ISO-induced myocardial damage was indicated by increased serum cardiac specific troponin I levels and cardiac marker enzyme activities including creatine kinase-MB, lactate dehydrogenase, aspartate transaminase, and alanine transaminase. Significant increases in serum total cholesterol, triglycerides, and low-density lipoprotein-cholesterol levels were also observed, along with a reduction in the serum high-density lipoprotein-cholesterol level. In addition to these diagnostic markers, the levels of lipid peroxide products were significantly increased. The activities of antioxidant enzymes such as superoxide dismutase, glutathione peroxidase, and glutathione reductase were significantly decreased in the hearts after ISO-induced myocardial infarction. However, pretreatment of ischemic rats with Sundarban honey brought the biochemical parameters to near normalcy, indicating the protective effect of Sundarban honey against ISO-induced ischemia in rats. Histopathological findings of the heart tissues further confirmed the biochemical findings, indicating that Sundarban honey confers protection against ISO-induced oxidative stress in the myocardium.
Metaproteomics reveals major microbial players and their biodegradation functions in a large-scale aerobic composting plant

Composting is an appropriate management alternative for municipal solid waste; however, our knowledge about the microbial regulation of this process is still scare. We employed metaproteomics to elucidate the main biodegradation pathways in municipal solid waste composting system across the main phases in a large‐scale composting plant. The investigation of microbial succession revealed that Bacillales, Actinobacteria and Saccharomyces increased significantly with respect to abundance in composting process. The key microbiologic population for cellulose degradation in different composting stages was different. Fungi were found to be the main producers of cellulase in earlier phase. However, the cellulolytic fungal communities were gradually replaced by a purely bacterial one in active phase, which did not support the concept that the thermophilic fungi are active through the thermophilic phase. The effective decomposition of cellulose required the synergy between bacteria and fungi in the curing phase.
Perception of focus and word order variability in Greek

This is an experimental study of prosodic focus and syntactic word order interactions with reference to agent/recipient semantic relations in Greek. In accordance with one perception experiment, the results in morphology neutral context indicate: (1) listeners do not perceive agent and recipient semantic distinctions and (2) prosody and focus applications do not thus have any perception effect whereas (3) word order has a major interference effect.
Effective dose of dexmedetomidine to induce adequate sedation in elderly patients under spinal anesthesia

Background During sedation with dexmedetomidine, a dose adjustment may be needed based on the invasiveness of the procedure, the patient's general condition, and their age. We aim here to determine the effective dose (ED) of dexmedetomidine to induce an adequate depth of sedation in elderly patients undergoing spinal anesthesia. Methods In this study, 47 patients aged 65 years or older, American Society of Anesthesiologists physical status I or II, undergoing spinal anesthesia were included. Patients were randomly allocated into group I, II, III, IV or V according to the dexmedetomidine loading dose of 0.1, 0.3, 0.5, 0.7 and 1.0 µg/kg, respectively. After spinal anesthesia, the assigned loading dose of dexmedetomidine was infused intravenously for 10 minutes, after which infusion was maintained at a rate of 0.3 µg/kg/h for the next 10 minutes in all groups. We assessed the depth of sedation with the Ramsay sedation scale every five minutes and measured vital signs and the oxygen saturation. The ED50 and ED95 of dexmedetomidine to obtain adequate sedation (Ramsay sedation score ≥ 3) upon the completion of the loading dose were calculated with logistic regression. Results The ED50 and ED95 of dexmedetomidine for adequate sedation were 0.29 µg/kg (95% confidence intervals [CI] 0.14-0.44) and 0.86 µg/kg (95% CI 0.52-1.20), respectively. Hypotension was frequent in groups IV, V compared to groups I, II, III (31.6 vs. 3.6%, P = 0.013). Conclusions ED95 of dexmedetomidine loading dose for adequate sedation is 0.86 µg/kg. However, dose higher than 0.5 µg/kg can lead to hemodynamic instability.
Patient acceptability of the Tecnis® multifocal intraocular lens

Cataract surgery has evolved. The goal of the surgeon includes both restoration of vision and refinement of vision. Patients’ desire for spectacle independence has driven the market for presbyopia-correcting cataract surgery and development of novel intraocular lens (IOL) designs. The Tecnis® Multifocal Intraocular Lens incorporates an aspheric, modified anterior prolate IOL with a diffractive multifocal lens design. The design aims to minimize spherical aberration and improve range of focus. The purpose of this review is to assess patient acceptability of the Tecnis® multifocal intraocular lens.
Video-assisted thoracic surgery versus open thoracotomy for non-small cell lung cancer: a meta-analysis of propensity score-matched patients.

OBJECTIVES This meta-analysis aimed to compare the perioperative outcomes of video-assisted thoracic surgery (VATS) with open thoracotomy for propensity score-matched patients with early-stage non-small cell lung cancer (NSCLC). METHODS Four relevant studies with propensity score-matched patients were identified from six electronic databases. Endpoints included perioperative mortality and morbidity, individual postoperative complications and duration of hospitalization. RESULTS Results indicate that all-cause perioperative mortality was similar between VATS and open thoracotomy. However, patients who underwent VATS were found to have significantly fewer overall complications, and significantly lower rates of prolonged air leak, pneumonia, atrial arrhythmias and renal failure. In addition, patients who underwent VATS had a significantly shorter length of hospitalization compared with those who underwent open thoracotomy. CONCLUSIONS In view of a paucity of high-level clinical evidence in the form of large, well-designed randomized controlled trials, propensity score matching may provide the highest level of evidence to compare VATS with open thoracotomy for patients with NSCLC. The present meta-analysis demonstrated superior perioperative outcomes for patients who underwent VATS, including overall complication rates and duration of hospitalization.
Encoding Temporal Information for Time-Aware Link Prediction

Most existing knowledge base (KB) embedding methods solely learn from time-unknown fact triples but neglect the temporal information in the knowledge base. In this paper, we propose a novel time-aware KB embedding approach taking advantage of the happening time of facts. Speciﬁcally, we use temporal order constraints to model transformation between time-sensitive relations and enforce the embeddings to be temporally consistent and more accurate. We empirically evaluate our approach in two tasks of link prediction and triple classiﬁcation. Experimental re-sults show that our method outperforms other baselines on the two tasks consistently.
Striatal Prediction Error Modulates Cortical Coupling

Both perceptual inference and motor responses are shaped by learned probabilities. For example, stimulus-induced responses in sensory cortices and preparatory activity in premotor cortex reflect how (un)expected a stimulus is. This is in accordance with predictive coding accounts of brain function, which posit a fundamental role of prediction errors for learning and adaptive behavior. We used functional magnetic resonance imaging and recent advances in computational modeling to investigate how (failures of) learned predictions about visual stimuli influence subsequent motor responses. Healthy volunteers discriminated visual stimuli that were differentially predicted by auditory cues. Critically, the predictive strengths of cues varied over time, requiring subjects to continuously update estimates of stimulus probabilities. This online inference, modeled using a hierarchical Bayesian learner, was reflected behaviorally: speed and accuracy of motor responses increased significantly with predictability of the stimuli. We used nonlinear dynamic causal modeling to demonstrate that striatal prediction errors are used to tune functional coupling in cortical networks during learning. Specifically, the degree of striatal trial-by-trial prediction error activity controls the efficacy of visuomotor connections and thus the influence of surprising stimuli on premotor activity. This finding substantially advances our understanding of striatal function and provides direct empirical evidence for formal learning theories that posit a central role for prediction error-dependent plasticity.
The Thalamus and Brainstem Act As Key Hubs in Alterations of Human Brain Network Connectivity Induced by Mild Propofol Sedation

Despite their routine use during surgical procedures, no consensus has yet been reached on the precise mechanisms by which hypnotic anesthetic agents produce their effects. Molecular, animal and human studies have suggested disruption of thalamocortical communication as a key component of anesthetic action at the brain systems level. Here, we used the anesthetic agent, propofol, to modulate consciousness and to evaluate differences in the interactions of remote neural networks during altered consciousness. We investigated the effects of propofol, at a dose that produced mild sedation without loss of consciousness, on spontaneous cerebral activity of 15 healthy volunteers using functional magnetic resonance imaging (fMRI), exploiting oscillations (<0.1 Hz) in blood oxygenation level-dependent signal across functionally connected brain regions. We considered the data as a graph, or complex network of nodes and links, and used eigenvector centrality (EC) to characterize brain network properties. The EC mapping of fMRI data in healthy humans under propofol mild sedation demonstrated a decrease of centrality of the thalamus versus an increase of centrality within the pons of the brainstem, highlighting the important role of these two structures in regulating consciousness. Specifically, the decrease of thalamus centrality results from its disconnection from a widespread set of cortical and subcortical regions, while the increase of brainstem centrality may be a consequence of its increased influence, in the mildly sedated state, over a few highly central cortical regions key to the default mode network such as the posterior and anterior cingulate cortices.
Regulation and Bonding: The Sarbanes-Oxley Act and the Flow of International Listings

ABSTRACT In this paper, we examine the economic impact of the Sarbanes-Oxley Act (SOX) by analyzing foreign listing behavior onto U.S. and U.K. stock exchanges before and after the enactment of SOX in 2002. Using a sample of all listing events onto U.S. and U.K. exchanges from 1995-2006, we develop an exchange choice model that captures firm-level, industry-level, exchange-level, and country-level listing incentives, and test whether these listing preferences changed following the enactment of SOX. After controlling for firm characteristics and other economic determinants of these firms' exchange choice, we find that the listing preferences of large foreign firms choosing between U.S. exchanges and the London Stock Exchange's (LSE) Main Market did not change following the enactment of SOX. In contrast, we find that the likelihood of a U.S. listing among small foreign firms choosing between the NASDAQ and LSE's Alternative Investment Market decreased following the enactment of SOX. The negative effect among small firms is consistent with these marginal companies being less able to absorb the incremental costs associated with SOX compliance. The screening of smaller firms with weaker governance attributes from U.S. exchanges is consistent with the heightened governance costs imposed by SOX increasing the bonding-related benefits of a U.S. listing. Copyright University of Chicago on behalf of the Institute of Professional Accounting, 2008.
Patterns of interference in sequence learning and prism adaptation inconsistent with the consolidation hypothesis.

The studies reported here used an interference paradigm to determine whether a long-term consolidation process (i.e., one lasting from several hours to days) occurs in the learning of two implicit motor skills, learning of a movement sequence and learning of a visuo-motor mapping. Subjects learned one skill and were tested on that skill 48 h later. Between the learning session and test session, some subjects trained on a second skill. The amount of time between the learning of the two skills varied for different subjects. In both the learning of a movement sequence and the learning of a visuo-motor mapping, we found that remote memories were susceptible to interference, but the passage of time did not afford protection from interference. These results are inconsistent with the long-term consolidation of these motor skills. A possible difference between these tasks and those that do show long-term consolidation is that the present tasks are not dynamic motor skills.
The Association between Trust in Health Care Providers and Medication Adherence among Black Women with Hypertension

Background: Black women have the highest prevalence of hypertension in the world. Reasons for this disparity are poorly understood. The historical legacy of medical maltreatment of Blacks in the U.S. provides some insight into distrust in the medical profession, refusal of treatment, and poor adherence to treatment regimens. Methods: Black women (N = 80) who were prescribed antihypertensive medications were recruited from urban communities in North Carolina. Study participants completed the Trust in Physician and Hill-Bone Compliance to High Blood Pressure Therapy questionnaires. An exact discrete-event model was used to examine the relationship between trust and medication adherence. Results: Mean age of study participants was 48 ± 9.2 years. The majority of participants (67%) were actively employed and 30% had incomes at or below the federal poverty level. Increasing levels of trust in the health care provider was independently associated with greater medication adherence (PTrend = 0.015). Conclusion: Black women with hypertension who trusted their health care providers were more likely to be adherent with their prescribed antihypertensive medications than those who did not trust their health care providers. Findings suggest that trusting relationships between Black women and health care providers are important to decreasing disparate rates of hypertension.
A STEEP FAINT-END SLOPE OF THE UV LUMINOSITY FUNCTION AT z ∼ 2–3: IMPLICATIONS FOR THE GLOBAL STELLAR MASS DENSITY AND STAR FORMATION IN LOW-MASS HALOS

We use the deep ground-based optical photometry of the Lyman Break Galaxy (LBG) Survey to derive robust measurements of the faint-end slope (α) of the UV luminosity function (LF) at redshifts 1.9 ⩽ z ⩽ 3.4. Our sample includes >2000 spectroscopic redshifts and ≈31000 LBGs in 31 spatially independent fields over a total area of 3261 arcmin2. These data allow us to select galaxies to 0.07L* and 0.10L* at z ∼ 2 and z ∼ 3, respectively. A maximum-likelihood analysis indicates steep values of α(z = 2) = −1.73 ± 0.07 and α(z = 3) = −1.73 ± 0.13. This result is robust to luminosity-dependent systematics in the Lyα equivalent width and reddening distributions, and is similar to the steep values advocated at z ≳ 4, and implies that ≈93% of the unobscured UV luminosity density at z ∼ 2–3 arises from sub-L* galaxies. With a realistic luminosity-dependent reddening distribution, faint to moderately luminous galaxies account for ≳70% and ≳25% of the bolometric luminosity density and present-day stellar mass density, respectively, when integrated over 1.9 ⩽ z < 3.4. We find a factor of 8–9 increase in the star-formation rate density between z ∼ 6 and z ∼ 2, due to both a brightening of L* and an increasing dust correction proceeding to lower redshifts. Combining the UV LF with stellar mass estimates suggests a relatively steep low-mass slope of the stellar mass function at high redshift. The previously observed discrepancy between the integral of the star-formation history and stellar mass density measurements at z ∼ 2 may be reconciled by invoking a luminosity-dependent reddening correction to the star-formation history combined with an accounting for the stellar mass contributed by UV-faint galaxies. The steep and relatively constant faint-end slope of the UV LF at z ≳ 2 contrasts with the shallower slope inferred locally, suggesting that the evolution in the faint-end slope may be dictated simply by the availability of low-mass halos capable of supporting star formation at z ≲ 2.
Resonance and frequency-locking phenomena in spatially extended phytoplankton–zooplankton system with additive noise and periodic forces

It is known that natural systems are undeniably subject to random fluctuations, arising from either environmental variability or internal effects. In this paper, we present a spatial version of the phytoplankton–zooplankton model that includes some important factors such as external periodic forces, noise, and diffusion processes. The spatially extended phytoplankton–zooplankton system is from the original study by Scheffer (Scheffer 1991 Oikos 62 271). Our results show that the spatially extended system exhibits a resonant pattern and frequency-locking phenomena. The system also shows that the noise and the external periodic forces play a constructive role in the Scheffer’s model: (i) the noise can enhance the oscillation of phytoplankton species’ density and form large clusters in space when the noise intensity is within a certain interval; (ii) the external periodic forces can induce 4:1 and 1:1 frequency-locking and spatially homogeneous oscillation phenomena to appear; and (iii) resonant patterns are observed in the system when the spatial noises and external periodic forces are both turned on. Moreover, we find that the 4:1 frequency locking transforms into 1:1 frequency locking when the noise intensity is increased. In addition to elucidating our results outside the domain of Turing instability, we provide further analysis of linear stability with the help of numerical calculation using the Maple software. Significantly, oscillations are enhanced in the system when the noise term is present. These results indicate that the oceanic plankton bloom may be partly due to interplay between the stochastic factors and external forces instead of deterministic factors. These results also may help us to understand the effects arising from the undeniable susceptibility to random fluctuations in oceanic plankton bloom.
Symmetric Determinantal Representation of Formulas and Weakly Skew Circuits

We deploy algebraic complexity theoretic techniques for constructing symmetric determinantal representations of formulas and weakly skew circuits. Our representations produce matrices of much smaller dimensions than those given in the convex geometry literature when applied to polynomials having a concise representation (as a sum of monomials, or more generally as an arithmetic formula or a weakly skew circuit). These representations are valid in any field of characteristic different from 2. In characteristic 2 we are led to an almost complete solution to a question of Burgisser on the VNP-completeness of the partial permanent. In particular, we show that the partial permanent cannot be VNP-complete in a finite field of characteristic 2 unless the polynomial hierarchy collapses.
Exponential Rate of Convergence to Equilibrium for a Model Describing Fiber Lay-Down Processes

This paper is devoted to the adaptation of the method developed in [4,3] to a Fokker-Planck equation for fiber lay-down which has been studied in [1,5]. Exponential convergence towards a unique stationary state is proved in a norm which is equivalent to a weighted $L^2$ norm. The method is based on a micro / macro decomposition which is well adapted to the diffusion limit regime.
Dragging Human Mesenchymal Stem Cells with the Aid of Supramolecular Assemblies of Single-Walled Carbon Nanotubes, Molecular Magnets, and Peptides in a Magnetic Field

Human adipose-derived stem cells (hASCs) are an attractive cell source for therapeutic applicability in diverse fields for the repair and regeneration of damaged or malfunctioning tissues and organs. There is a growing number of cell therapies using stem cells due to their characteristics of modulation of immune system and reduction of acute rejection. So a challenge in stem cells therapy is the delivery of cells to the organ of interest, a specific site. The aim of this paper was to investigate the effects of a supramolecular assembly composed of single-walled carbon nanotubes (SWCNT), molecular magnets (lawsone-Co-phenanthroline), and a synthetic peptide (FWYANHYWFHNAFWYANHYWFHNA) in the hASCs cultures. The hASCs were isolated, characterized, expanded, and cultured with the SWCNT supramolecular assembly (SWCNT-MA). The assembly developed did not impair the cell characteristics, viability, or proliferation. During growth, the cells were strongly attached to the assembly and they could be dragged by an applied magnetic field of less than 0.3 T. These assemblies were narrower than their related allotropic forms, that is, multiwalled carbon nanotubes, and they could therefore be used to guide cells through thin blood capillaries within the human body. This strategy seems to be useful as noninvasive and nontoxic stem cells delivery/guidance and tracking during cell therapy.
An efficient method for chaotic signal parameter estimation

Chaotic signals represent a new class of signals that can be applied in a wide range of signal processing applications. This paper describes an efficient method for parameter estimation of chaotic sequences generated by iterating tent maps with a known initial condition, and observed in white noise. The method is based on the connection between the symbolic sequence associated to the chaotic signal and the parameter of the tent map. The proposed method is asymptotically unbiased, and is found to attain the Cramer-Rao Lower Bound (CRLB) for a high Signal to Noise Ratio (SNR).