Miracle-dz/UniFAR-FTUs huggingface dataset:
Phenelzine: An Old Drug That May Hold Clues to The Development of New Neuroprotective Agents

5 OZET: Fenelzin: Eski bir ilac, yeni noroprotektif ajanlar›n gelifltirilmesine ipuclar› tutabilir Panik bozukluk ve sosyal anksiyete bozukluu gibi anksiye- te bozukluklar›n›n tedavisinde kullan›lan monoamin oksi- daz (MAO) inhibitoru bir antidepresan olan fenelzinin geci- ci onbeyin iskemisi olan bir hayvan modelinde noroprotek- tif etkileri olduu gosterilmifltir. Fenelzinin MAO inhibisyo- nu etkisi yan› s›ra farmakolojik ve terapotik profiline ekle- nebilir cok say›da etkisi vard›r. Bu etkiler GABA transamina- z›n inhibisyonuyla beyin GABA duzeylerini artt›rmas›, glu- tamat›n ifllevsel durumu uzerine etkileri, reaktif aldehitlerin tutulumu, primer amin oksidaz inhibisyonu ve beyin kay- nakl› norotrofik faktor (BDNF) uzerindeki etkilerin inhibe edilmesidir. 2-Feniletilidenehidrazin, fenelzinin onemli bir metabolit olup GABA beyin duzeylerini artt›rd›¤› gosteril- mifltir ve gecici onbeyin iskemisi modelinde reaktif aldehit- lerin tutulumu ve noroprotektif etkileri keflfedilmifltir. Fe- nelzin ve feniletilidenehidrazin bu etkileri nedeniyle ozel- likle norodejenerasyon iceren psikiyatrik ve norolojik bo- zukluklar›n tedavisi icin gelecekte ilac tasar›m› yonunden goz onunde tutulmal›d›r. ABSTRACT: Phenelzine: An old drug that may hold clues to the development of new neuroprotective agents The monoamine oxidase (MAO)-inhibiting antidepressant phenelzine (PLZ) is also used in the treatment of anxiety disorders such as panic disorder and social anxiety disorder and has been shown to have neuroprotective actions in an animal model of transient forebrain ischemia. Phenelzine has multiple actions in addition to inhibition of MAO that may contribute to its pharmacological and therapeutic profile. These actions include inhibition of GABA transaminase and elevation of brain levels of GABA, effects on functional availability of glutamate, sequestration of reactive aldehydes, inhibition of primary amine oxidase and effects on brain-derived neurotrophic factor (BDNF). 2- Phenylethylidenehydrazine (PEH) has been identified as a major metabolite of PLZ and has also been shown to elevate brain levels of GABA, to sequester reactive aldehydes and to exert neuroprotective effects in a transient forebrain ischemia model. The actions of PLZ and PEH should be considered when designing future drugs for the treatment of psychiatric and neurologic disorders, particularly those involving neurodegeneration.
Burst-Error Analysis of Dual-Hop Fading Channels Based on the Second-Order Channel Statistics

The burst-error (BE) rate of dual-hop fading channels under a fixed fade threshold is estimated based on the level crossing rate (LCR) and average fade duration (AFD). The LCR and AFD of the equivalent signal-to-noise ratio (SNR) are first derived for dual-hop Nakagami-m and Weibull fading channels with a fixed-gain amplify-and-forward (AF) relay, where closed-form lower and upper bounds are derived for the LCR and AFD of the Nakagami-m fading channels. Numerical results from theoretical evaluations and Monte Carlo simulations are illustrated to validate the analysis and to compare the performance of the two fading channels.
Effects of granulocyte-colony stimulating factor and the expression of its receptor on various malignant cells

Background Granulocyte-colony stimulating factor (G-CSF) is extensively used to improve neutrophil count during anti-cancer chemotherapy. We investigated the effects of G-CSF on several leukemic cell lines and screened for the expression of the G-CSF receptor (G-CSFR) in various malignant cells. Methods We examined the effects of the most commonly used commercial forms of G-CSF (glycosylated lenograstim and nonglycosylated filgrastim) on various leukemic cell lines by flow cytometry. Moreover, we screened for the expression of G-CSFR mRNA in 38 solid tumor cell lines by using real-time PCR. Results G-CSF stimulated proliferation (40-80% increase in proliferation in treated cells as compared to that in control cells) in 3 leukemic cell lines and induced differentiation of AML1/ETO+ leukemic cells. Among the 38 solid tumor cell lines, 5 cell lines (hepatoblastoma, 2 breast carcinoma, squamous cell carcinoma of the larynx, and melanoma cell lines) showed G-CSFR mRNA expression. Conclusion The results of the present study show that therapeutic G-CSF might stimulate the proliferation and differentiation of malignant cells with G-CSFR expression, suggesting that prescreening for G-CSFR expression in primary tumor cells may be necessary before using G-CSF for treatment.
Generation of melanocytes from neural crest cells

The neural crest is a transient structure in vertebrate embryos that generates multiple neural and mesenchymal cell types as well as melanocytes. Melanocytes in the skin either derive directly from neural crest cells populating the skin via a dorsolateral migratory pathway or arise by detaching from nerves innervating the skin. Several transcription factors, such as FoxD3, Sox10, Pax3, and Mitf, take part in a genetic network regulating melanocyte formation from the neural crest. The activity of these intrinsic factors is controlled and modulated by extracellular signals including canonical Wnt, Edn, Kitl, and other signals that remain to be identified. Here, we summarize the current view of how melanocytes are specified from the neural crest and put this process into the context of spatiotemporal lineage decisions in neural crest cells.
Cognitive Therapy and the Emotional Disorders

Is the emotionally disturbed person a victim of forces beyond his awareness, over which he has no control? This is the belief on which neuropsychiatry, psychoanalysis, and behaviour therapy are all based. But what if this premise is wrong? What if a person's psychological difficulties stem from his own erroneous assumptions and faulty concepts of himself and the world? Such a person can be helped to recognize and correct distortions in thinking that cause his emotional disturbance. Now one of the founders of cognitive therapy has written a clear, comprehensive guide to its theory and practice, highlighting such important concepts as learning the meaning of hidden messages - listening to your automatic thoughts - the role of sadness, anger and anxiety - understanding and overcoming phobias and depression.
Bone protection with salmon calcitonin (sCT) in the long-term steroid therapy of chronic sarcoidosis.

Prednisone-induced osteoporosis is very frequent in the long-term treatment of sarcoidosis (sarcoidosis 4:45-48, 1987). The aim of this work is to evaluate if salmon Calcitonin (sCT) is able to prevent osteopenia in the long-term. We have studied 53 patients with chronic histologically-proven sarcoidosis, all needing steroids, in a follow-up of 15 months; 20 of them were protected with sCT (100 I.U. i.m. daily for one month, then every two days for all the time of the study), 33 were unprotected. The two groups were matched for age, sex and total dose of prednisone. In order to overcome the differences of Vertebral Cancellous Mineral Content (VCMC) due to age and sex, we express VCMC in terms of Z score, i.e. the number of standard deviations above or below our normal means: initial Z score was -1.77 +/- 0.16 in the sCT group and -0.99 +/- 0.17 in the other group (P less than .05). For each subject we calculated the Mineral Loss (ML) in % of the initial value. At the end of the study ML% averaged -2.15(+/- 2.27) in the sCT protected group, and -14.11(+/- 2.08) in the unprotected group (P less than .001). We have also analysed the results limited to pts with initial Z score under -1 (19 sCT protected pts vs 18 unprotected). In these subgroups the ML% after 15 months averaged -13.62(+/- 2.9) in the unprotected group and -2.80(+/- 2.29) in the protected one (P less than .01). Finally we have studied another subgroup, i.e. 21 postmenopausal females: 9 were sCT protected, 12 were unprotected. (ABSTRACT TRUNCATED AT 250 WORDS)
2,9-Dicarbonyl-1,10-phenanthroline derivatives with an unprecedented Am(III)/Eu(III) selectivity under highly acidic conditions.

Four lipophilic 1,10-phenanthroline di(thio)amide, diester or diketone derivatives were studied as ligands for Am(III)/Eu(III) separation from acidic media. The synthesis of these compounds is reported together with the extraction tests in different solvents (kerosene, octanol and o-nitrophenyl hexyl ether), HNO3 concentrations and ratios between the ligand and the synergistic agent (Br-Cosan). The promising results obtained from the large number of solvent extraction tests carried out show that it might be possible to apply this class of ligands to advanced reprocessing of spent nuclear fuel. The experimental data indicate that, under the conditions that simulate the real radioactive waste, the extraction efficiency and Am/Eu separation factors are particularly high, thus suggesting that the combination of soft heterocyclic N-donor atoms and hard carbonyl groups of ester and amides affords a tetradentate donor set of atoms (ONNO) that gives rise to remarkable selectivities. ESI-MS studies and DFT calculations shed light on the possible structure of the Eu(3+) complexes indicating that the 1 : 1 : 2 (cation : ligand : anion) complex is slightly more stable than the 1 : 2 : 1 species.
Adaptive geographical clines in the growth and defense of a native plant

Broad-scale geographical gradients in the abiotic environment and interspecific interactions should select for clinal adaptation. How trait clines evolve has recently received increased attention because of anticipated climate change and the importance of rapid evolution in invasive species. This issue is particularly relevant for clines in growth and defense of plants, because both sets of traits are closely tied to fitness and because such sessile organisms experience strong local selection. Yet despite widespread recognition that growth and defense traits are intertwined, the general issue of their joint clinal evolution is not well resolved. To address heritable clinal variation and adaptation of growth and defense traits of common milkweed (Asclepias syriaca), we planted seed from 22 populations encompassing the species' latitudinal range in common gardens near the range center (New York) and toward the range edges (New Brunswick and North Carolina). Populations were differentiated in 13 traits, and .
The impact of apologies and promises on post‐violation trust

Purpose – This research aims to separate the effect of a promise from an apology, examine interactional justice as a theoretical mechanism explaining the relationship between these accounts and post‐violation trust, examine how message content compares to the gesture of sending a message, and test offense severity as a moderator.Design/methodology/approach – This study employed the Trust Game.Findings – Results indicated significant apology × promise and apology × promise × offense severity interactions on interactional justice, and interactional justice fully mediated the relationship between promises and post‐violation trust.Research limitations/implications – Although this study was completed using a laboratory game with anonymous partners, results suggest that interactional justice provides a means for relationships to quickly get back on track after a violation. Specifically, promises provide “forward‐looking” information (trustworthy intent) and interpersonal sensitivity (demonstration of courtesy a.
Synchrophasor Measurement Technology in Power Systems: Panorama and State-of-the-Art

Phasor measurement units (PMUs) are rapidly being deployed in electric power networks across the globe. Wide-area measurement system (WAMS), which builds upon PMUs and fast communication links, is consequently emerging as an advanced monitoring and control infrastructure. Rapid adaptation of such devices and technologies has led the researchers to investigate multitude of challenges and pursue opportunities in synchrophasor measurement technology, PMU structural design, PMU placement, miscellaneous applications of PMU from local perspectives, and various WAMS functionalities from the system perspective. Relevant research articles appeared in the IEEE and IET publications from 1983 through 2014 are rigorously surveyed in this paper to represent a panorama of research progress lines. This bibliography will aid academic researchers and practicing engineers in adopting appropriate topics and will stimulate utilities toward development and implementation of software packages.
Différences de genre en matière de mobilité professionnelle des migrants congolais (RDC) en Belgique

L’objectif de cet article est d’etudier la mobilite professionnelle des migrants congolais (RDC) en Belgique. Dans un premier temps, nous mettons en evidence les caracteristiques des migrants congolais vivant en Belgique a travers leur niveau d’instruction et leur statut professionnel. En depit de leur niveau de qualification assez eleve, les migrants congolais connaissent un fort taux de sous-emploi et, lorsqu’ils travaillent, un certain nombre d’entre eux doivent faire face au probleme de surqualification. La comparaison de leur situation sur le marche de l’emploi en RDC et en Belgique nous permet de voir si leur migration en Belgique les a conduits a une mobilite professionnelle horizontale, verticale ascendante ou verticale descendante. Dans un second temps, nous etudions les facteurs les plus associes a cette mobilite professionnelle. Cette mobilite est apprehendee a travers l’etude de caracteristiques sociodemographiques (sexe, âge, situation familiale, nationalite), des facteurs lies au capital humain (diplome obtenu, experience passee), ainsi que des determinants en termes de capital social (connaissances dans le pays de destination) et lies au projet migratoire (raisons du depart, papiers). Les resultats indiquent que les femmes sont plus susceptibles que les hommes de connaitre un declassement professionnel, particulierement lorsque leur migration s’inscrit dans le cadre d’un regroupement familial. Les hommes sont , quant a eux, davantage susceptibles de trouver un emploi similaire a celui qu’ils avaient en RD Congo, surtout s’ils connaissent des proches en Belgique.
A critical examination of women's work-family conflict and career aspirations in the Chinese airline industry

Work demands and family responsibilities are often seen to be incompatible and, in the light of increasing female participation in paid employment, there is a growing concern about work-family conflict for women worldwide. Western literature suggests that both work and family-related factors give rise to women's work-family conflict. Also, the persistence of a gendered division of domestic labour - mainly arising from the role of women as the principle child-rearers and carers - have provided explanations for the continued disadvantage that women experience in the workplace. This study examines the extent to which these Western experiences prevail in modern China and considers the full range of factors within the Chinese context in order to develop an understanding of how work and family conflict for Chinese women. The empirical evidence reported was collected from case studies conducted in three Chinese airlines. Through the use of a multi-method approach - including questionnaires, qualitative interviews and documentary analysis - rich data has enabled insights to be gained into the issue of work-family conflict in the Chinese airline industry in particular and the Chinese context more broadly. The research shows that Western findings are not wholly applicable in the Chinese context because of a unique mix of traditional Chinese values alongside contemporary social, political and economic changes which enable women to participate more freely in the labour market. While it is found that family to work conflict is diminishing, significant work to family conflict is experienced mainly as a consequence of negative gendered organisational attitudes. This research builds upon Venter's (2002) three-level model of women's work-family experiences by developing a six-factor analytical model which enables a fuller understanding of women's work-family conflict and other relevant issues. The six-factor model also provides a framework for enhancing current knowledge about the lives of Chinese working women more generally.
Real time Hand Gesture Recognition using a Range Camera

This paper proposes a real time hand gesture recognition system. The approach uses a range camera to capture the depth data. After some preprocessing procedures, the depth data is used to segment the hand and then locate the hand in 3D space. The hand shape is classified into known categories using a chamfer matching method to measure the similarities between the candidate hand image and the hand templates in the database. The 3D hand trajectory is recognized by a Finite State Machine (FSM) method. Each gesture consists of several states. The 3D hand position determines the state transition of each gesture recognizer. Experiments show that the system performs reliably for recognizing both static hand shapes and spatial-temporal trajectories in real time.
From Public Service Media Organisations to De-centralised Public Service for the Media Sector: A Comparative Analysis of Opportunities and Disadvantages

Ideas on plurality and competition in public broadcasting delivery have re-surfaced in discussions on the future of public surface media (PSM) on regular occasions in different geographical settings since the 1980s. This article analyses several of the debates on distributed public service, critically evaluating whether governments across Europe would indeed be “better off” should they choose a distributed and de-centralised model of public service media. The article, firstly, investigates which arguments have been made in order to make the case for a distributed PSM model. On the basis of these insights, a typology of different forms of distributed public service delivery is then developed. Setting out from this typology, policy plans and actual practices of de-centralised PSM are being analysed. Findings in the four case studies (the United Kingdom, Flanders, the Netherlands, and New Zealand) are based on a combination of secondary literature, a qualitative document analysis, desk research and semi-structured expert interviews. The article concludes that distributed public service is as much a normative idea as the centralised public broadcasting project, that distributed public service as a policy solution lacks a clearly defined policy problem and, moreover, that there is, given the variety of media systems, not one distributed model that would fit all.
Annotating Named Entities in Twitter Data with Crowdsourcing

We describe our experience using both Amazon Mechanical Turk (MTurk) and Crowd-Flower to collect simple named entity annotations for Twitter status updates. Unlike most genres that have traditionally been the focus of named entity experiments, Twitter is far more informal and abbreviated. The collected annotations and annotation techniques will provide a first step towards the full study of named entity recognition in domains like Facebook and Twitter. We also briefly describe how to use MTurk to collect judgements on the quality of "word clouds. "
THE IMPACT OF WORKING ENVIRONMENT TOWARDS EMPLOYEE JOB SATISFACTION: A CASE STUDY IN PT. X

Employee job satisfaction is a parameter that measures the depth of Employee affectionate or positive experience derived from the work. Researchers have mentioned that employees with higher satisfaction tend to be more loyal and productive, yet there are no exact formula on maximizing employee job satisfaction, let alone a research to serve as an exact parameter of the factors influencing the job satisfaction. The writer’s purpose in this study is to examine and analyze the influence of the working environment condition towards employee job satisfaction and to provide insight on how to increase employee job satisfaction through the work environment. The writer is using the multiple regression analysis with 74 samples to measure the significance of work environment towards the job satisfaction through the distribution of questionnaire in PT. X. The result of this research shows that simultaneously work environment factors is significant towards the employee job satisfaction. Keywords: Work Environment, Job Satisfaction, Human Resource Management, Gas Industry. Normal 0 false false false EN-US X-NONE X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin-top:0cm; mso-para-margin-right:0cm; mso-para-margin-bottom:8.0pt; mso-para-margin-left:0cm; line-height:107%; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi; mso-ansi-language:EN-US; mso-fareast-language:EN-US;}
Do Reputation Concerns Make Behavioral Biases Disappear? The Conjunction Fallacy on Facebook and Mechanical Turk

This paper reports the results of experiments designed to test whether individuals interacting on Facebook are more likely to succumb to the conjunction fallacy when they post their answers publicly and are exposed to the answers of others. Using the experimental design in Kahneman and Tversky (1983), we find that the proportion of individuals violating the conjunction rule on Facebook is substantially lower than that reported by previous experiments conducted in the lab, regardless of whether responses are public or private. When responses are posted in a public form, however, the partic- ipation rate is substantially higher. The violation rate on Facebook is also significantly lower than the rate of violation from the same experiment run on Mechanical Turk, a popular online labor market, with monetary incentives. Adding a bonus for the correct answer reduces the violation rate on Mechanical Turk when answers are private, but not when they are public, suggesting that peer effects may indeed counteract the effect of monetary incentives. Our experiment casts doubts about the robustness of behavioral biases for the understanding of real life decisions in environments in which interaction is not anonymous and people are reputation conscious, and suggests the power of social networks to mitigate their effects
Brand Performance Volatility Arising from Marketing Spending Behavior under Competition

While volatile marketing spending, as opposed to even-level spending, may improve a brand’s financial performance, it can also increase the volatility of performance, which is not a desirable outcome. This paper analyzes how revenue and cash-flow volatility are influenced by own and competitive marketing spending volatility, by the level of marketing spending, by the responsiveness of own marketing spending, and by competitive reactivity. From market response theory, we derive propositions about the influence of these variables on revenue and cash-flow volatility. Based on a broad sample of 99 pharmaceutical brands in four clinical categories and four European countries, the authors test for the empirical relevance of the propositions and assess the magnitude of the different sources of marketinginduced performance volatility. The authors find broad support for the predicted volatility effects. The results suggest that volatile marketing spending may incur negative financial side effects such as greater financing costs or higher opportunity costs of cash holdings. Thus common volatilityincreasing marketing practices such as advertising pulsing may be effective at the top-line, but could turn out to be ineffective after all costs are taken into account.