Miracle-dz/UniFAR-FTUs huggingface dataset:
Magnon spin transport driven by the magnon chemical potential in a magnetic insulator

We develop a linear-response transport theory of diffusive spin and heat transport by magnons in magnetic insulators with metallic contacts. The magnons are described by a position-dependent temperature and chemical potential that are governed by diffusion equations with characteristic relaxation lengths. Proceeding from a linearized Boltzmann equation, we derive expressions for length scales and transport coefficients. For yttrium iron garnet (YIG) at room temperature we find that long-range transport is dominated by the magnon chemical potential. We compare the model's results with recent experiments on YIG with Pt contacts [L. J. Cornelissen, Nat. Phys. 11, 1022 (2015)1745-247310.1038/nphys3465] and extract a magnon spin conductivity of σm=5×105 S/m. Our results for the spin Seebeck coefficient in YIG agree with published experiments. We conclude that the magnon chemical potential is an essential ingredient for energy and spin transport in magnetic insulators.
Correlation of dynamic cartilage contact stress aberrations with severity of instability in ankle incongruity

Joint instability is presumed to cause abnormality in cartilage contact mechanics, which accumulatively damages the articular surface, leading to osteoarthritis. The purpose of this study was to clarify the effect of instability on dynamic cartilage contact mechanics. Using human ankle cadaver specimens, potentially unstable ankles were modeled by introducing a coronally directed step‐off incongruity of the anterior tibial surface and/or by transecting the anterior talofibular ligament. Specimens were subjected to a duty cycle with quasi‐physiologic stance‐phase motion and loading. AP tibial forces were modulated, causing a controlled, quantifiable ankle subluxation during the duty cycle. Instantaneous changes in local articular contact stresses were continuously measured using a thin, flexible pressure transducer. Tests were repeated while varying the tibial surface condition (anatomic, 1‐mm step‐off, and 2‐mm step‐off), both before and after transection of the anterior talofibular ligament, with various AP force magnitudes, so that situations of various degrees of instability were created for each specimen. Instability events occurred when the step‐off incongruity was introduced, with the abnormality in joint kinematics being greater after ligament transection. Contact stress data revealed that these instability events involved distinctly abrupt increases/decreases in local articular contact stresses, and that the degree of abruptness was correlated nearly linearly with the abnormality in kinematics. The severity of contact stress aberration appeared to be correlated with the degree of instability. Given this linear relationship, even small instability events presumably involve appreciable abnormality in dynamic joint contact mechanics. © 2008 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 26:1186–1193, 2008
The ensemble folding kinetics of the FBP28 WW domain revealed by an all‐atom Monte Carlo simulation in a knowledge‐based potential

In this work, we apply a detailed all‐atom model with a transferable knowledge‐based potential to study the folding kinetics of Formin‐Binding protein, FBP28, which is a canonical three‐stranded β‐sheet WW domain. Replica exchange Monte Carlo simulations starting from random coils find native‐like (Cα RMSD of 2.68 Å) lowest energy structure. We also study the folding kinetics of FBP28 WW domain by performing a large number of ab initio Monte Carlo folding simulations. Using these trajectories, we examine the order of formation of two β‐hairpins, the folding mechanism of each individual β‐hairpin, and transition state ensemble (TSE) of FBP28 WW domain and compare our results with experimental data and previous computational studies. To obtain detailed structural information on the folding dynamics viewed as an ensemble process, we perform a clustering analysis procedure based on graph theory. Further, a rigorous Pfold analysis is used to obtain representative samples of the TSEs showing good quantitative agreement between experimental and simulated Φ values. Our analysis shows that the turn structure between first and second β strands is a partially stable structural motif that gets formed before entering the TSE in FBP28 WW domain and there exist two major pathways for the folding of FBP28 WW domain, which differ in the order and mechanism of hairpin formation. Proteins 2011. © 2011 Wiley‐Liss, Inc.
Decision-making, Impulsivity and Self-control: Between-person and Within-person Predictors of Risk-taking Behavior

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"Why bother? It's gonna hurt me": the role of interpersonal cognitive biases in the development of anxiety and depression

Child and adolescent mood and anxiety symptoms are common and debilitating, with long-term effects on well-being. Research presented in this thesis examines interpersonal cognitive factors in the emergence of anxious and depressive symptoms in late childhood through to early adulthood. The thesis considers this issue using three main approaches. For the first, data are presented showing that biases in the appraisals of social situations are the aspects of interpersonal cognition most closely associated with emotional symptoms. For the second, longitudinal twin data are used to examine genetic and environmental origins of these interpersonal cognitive biases and their temporal prediction of symptoms across a 2-year period. Data show that interpersonal cognitive factors are strongly influenced by non-shared environmental factors, and moreover, predict symptoms across time. The final section of the thesis comprises four studies using Cognitive Bias Modification of Interpretations (CBM-I) training methodology to show that both positive and negative interpretive biases for interpersonal information can be induced in adolescents. Positive biases are shown to persist for at least 24 hours after training, and induced positive and negative biases are shown to differentially predict anxious responses to an experimental stressor. Evidence is also provided to suggest that effects following training positive interpretive biases may transfer to other cognitive measures, namely appraisals of ambiguous emotional faces. Finally, data tentatively show that CBM-I training may be useful in reducing negative interpretations of interpersonal information made by 11-year-old children undergoing the transition to secondary school. In summary, studies in this thesis support the contribution of cognitive biases to mood and anxiety symptoms in childhood and adolescence. They further extend this knowledge by suggesting that these reflect individual-specific (non-shared) environmental risks to predict symptoms across time. These biases may also be amenable to change through training interventions, with some - albeit weak - effects on other cognitive outcomes.
Histopathological Changes of the Heart After Neonatal Dexamethasone Treatment: Studies in 4-, 8-, and 50-Week-Old Rats

Dexamethasone (Dex), for prevention of chronic lung disease in preterm infants, showed potential negative long-term effects. Studies regarding long-term cardiovascular effects are lacking. We investigated possible histopathological myocardial changes after neonatal Dex in the young and adult rat heart. Rats were treated with Dex on d 1, 2, and 3 (0.5, 0.3, and 0.1 mg/kg) of life. Control-pups received saline. At 4, 8, and 50 wk after birth rats were killed and anatomic data collected. Heart tissue was stained with hematoxylin and eosin, Cadherin-periodic acid schiff, and sirius red for cardiomyocyte morphometry and collagen determination. Presence of macrophages and mast cells was analyzed. Cardiomyocyte length of the Dex-treated rats was increased in all three age groups, whereas ventricular weight was reduced. Cardiomyocyte volumes were increased at 50 wk indicating cellular hypertrophy. Collagen content gradually increased with age and was 62% higher in Dex rats at 50 wk. Macrophage focus score and mast cell count were also higher. Neonatal Dex affects normal heart growth resulting in cellular hypertrophy and increased collagen deposition in the adult rat heart. Because previous studies in rats showed premature death, suggesting cardiac failure, cardiovascular follow-up of preterm infants treated with glucocorticoids should be considered.
Bernstein–Sato polynomials of arbitrary varieties

We introduce the notion of the Bernstein–Sato polynomial of an arbitrary variety (which is not necessarily reduced nor irreducible) using the theory of V-filtrations of M. Kashiwara and B. Malgrange. We prove that the decreasing filtration by multiplier ideals coincides essentially with the restriction of the V-filtration. This implies a relation between the roots of the Bernstein–Sato polynomial and the jumping coefficients of the multiplier ideals, and also a criterion for rational singularities in terms of the maximal root of the polynomial in the case of a reduced complete intersection. These are generalizations of the hypersurface case. We can calculate the polynomials explicitly in the case of monomial ideals.
An adolescent's subjective experiences of mindfulness

An adolescent's subjective experiences of mindfulness were explored in a single case study of a 17-year-old female. Data were created by means of ‘mindfulness sessions’, unstructured interviews, creative expression, journals and field notes. The data were analysed and interpreted using a combination of typological and interpretive analysis strategies. Findings are presented within a conceptual framework of mindfulness derived by the main author from the literature review. Five themes emerged from the data in relation to the conceptual framework applied, namely present-centered awareness and attention, attitude and heart qualities, self-regulation, universalism and mindlessness. Overall findings suggest firstly that the participant subjectively experienced mindfulness as being predominantly task-oriented. Secondly, it appears that the participant experienced personal growth and development in terms of her understanding and practice of mindfulness. These findings could make a potential contribution towards qualitative research on mindfulness, and research on how mindfulness could possibly apply to an adolescent. Studies have shown mindfulness to be a potentially promising intervention and quality to be cultivated in the development of well-being. The study is thus significant in the context of positive psychology and a move towards more holistic health and well-being.
Hydrofluoroalkane-134A Beclomethasone or Chlorofluorocarbon Fluticasone: Effect on Small Airways in Poorly Controlled Asthma

Inflammation in asthma extends into the small airways (< 2 mm diameter). Most inhaled corticosteroids are suspensions with a particle size > 2 mm. Therefore, inflammation in the small airways of patients with asthma may not be adequately treated with these preparations. Some inhaled corticosteroids, on the other hand, are compounded with alcohol, resulting in a solution producing an aerosol that has a mean particle diameter of < 2 mm. This study was designed to compare the addition of equivalent amounts of two inhaled corticosteroids (one a suspension and one a solution) to the treatment of patients with asthma, which was uncontrolled despite treatment with moderate to high doses of inhaled corticosteroids and usually additional controller medications. The study was performed with 30 patients, ≥ 18 years of age. Subjects were randomized in a single-blind fashion to receive, in addition to their current asthma therapy, either CFC-FP 220 µg each morning and 110 µg each evening (n = 10) or HFA-BDP 160 mcg twice daily (n = 20). Pre- and postbronchodilator spirometry, single breath nitrogen washout for closing volume and residual volume by plethysmography were assessed before and after 3 months of therapy. In the subjects who received HFA-BDP, the ratio of closing volume (CV) to vital capacity (VC) and residual volume (RV) decreased significantly (p = 0.0214 and 0.0433, respectively), whereas forced expiratory flow over 25–75% of the vital capacity (FEF25–75%), forced expiratory volume in 1 second (FEV1), and morning peak flow improved significantly (p = 0.0014, 0.0184, and 0.0321). Improvements from baseline of CV, CV/VC, and postbronchodilator FEF25–75%, were statistically significant in the HFA-BDP group compared with the CFC-FP group (p = 0.0049, 0.0194, and 0.0355, respectively). These preliminary findings suggest that the addition of HFA-BDP, compared with CFC-FP in patients with poorly controlled asthma despite receiving moderate to high doses of inhaled steroids, has a greater effect on parameters reflecting small airway patency presumably secondary to reduction in inflammation.
Periodic Graphs

Let X be a graph on n vertices with with adjacency matrix A and let H(t) denote the matrix-valued function exp(iAt). If u and v are distinct vertices in X, we say perfect state transfer from u to v occurs if there is a time τ such that |H(τ)u,v| = 1. If u ∈ V (X) and there is a time σ such that |H(σ)u,u| = 1, we say X is periodic at u with period σ. We show that if perfect state transfer from u to v occurs at time τ , then X is periodic at both u and v with period 2τ . We extend previous work by showing that a regular graph with at least four distinct eigenvalues is periodic with respect to some vertex if and only if its eigenvalues are integers. We show that, for a class of graphs X including all vertex-transitive graphs, if perfect state transfer occurs at time τ , then H(τ) is a scalar multiple of a permutation matrix of order two with no fixed points. Using certain Hadamard matrices, we construct a new infinite family of graphs on which perfect state transfer occurs.
Arabidopsis RNA-Dependent RNA Polymerases and Dicer-Like Proteins in Antiviral Defense and Small Interfering RNA Biogenesis during Turnip Mosaic Virus Infection[W][OA]

Viruses promote infection by suppressing antiviral RNA silencing responses. Using suppressor-deficient and suppressor-competent Turnip mosaic virus, a genetic analysis of antiviral RNA silencing showed that Arabidopsis Dicers and RNA-dependent RNA polymerases have modular roles in antiviral defense. Plants respond to virus infections by activation of RNA-based silencing, which limits infection at both the single-cell and system levels. Viruses encode RNA silencing suppressor proteins that interfere with this response. Wild-type Arabidopsis thaliana is immune to silencing suppressor (HC-Pro)-deficient Turnip mosaic virus, but immunity was lost in the absence of DICER-LIKE proteins DCL4 and DCL2. Systematic analysis of susceptibility and small RNA formation in Arabidopsis mutants lacking combinations of RNA-dependent RNA polymerase (RDR) and DCL proteins revealed that the vast majority of virus-derived small interfering RNAs (siRNAs) were dependent on DCL4 and RDR1, although full antiviral defense also required DCL2 and RDR6. Among the DCLs, DCL4 was sufficient for antiviral silencing in inoculated leaves, but DCL2 and DCL4 were both involved in silencing in systemic tissues (inflorescences). Basal levels of antiviral RNA silencing and siRNA biogenesis were detected in mutants lacking RDR1, RDR2, and RDR6, indicating an alternate route to form double-stranded RNA that does not depend on the three previously characterized RDR proteins.
Enhancement of Chlorophyll a Production from Marine Spirulina maxima by an Optimized Ultrasonic Extraction Process

Under the optimal ultrasonification extraction conditions of 20.52 kHz for the frequency, 32.59 °C for the temperature, and 4.91 h for the process time, 17.98 mg/g of chlorophyll a was obtained. It was much higher than 13.81 mg/g from conventional 70% ethanol extraction and even higher than other data from Spirulina. This yield was close to the predicted value of 18.21 mg/g from the second-order polynomial model with a regression coefficient of 0.969. This model showed the greatest significance with the ultrasonic frequency and process time and the least significance with the temperature. The extracts also showed high α,α-diphenyl-β-picrylhydrazyl (DPPH) radical scavenging activities as 69.38%, compared to 58.25% for the extracts from the 70% ethanol extraction. It was first shown that the optimal extraction was effective at enhancing the neuroprotective activities possibly due to the synergistic effects of higher amounts of chlorophyll a and other bioactive substances in the extract, revealing a 90% protection of the growth of mouse neuronal cells and a great reduction in Reactive Oxygen Species (ROS) production.
Understanding and Promoting Transformative Learning: A Guide for Educators of Adults

Patricia Cranton’s ongoing exploration of the transformative power of teaching and learning is compellingly described and documented in this second edition of Understanding and Promoting Transformative Learning: A Guide for Educators of Adults . In her preface, Cranton reiterates the original intention of her 1994 book, namely, “to explain transformative learning theory, describe the process from the learners’ perspective, explore individual differences in transformative learning, present practical strategies for fostering transformative learning, and discuss how adult educators themselves are transformative learners” (p. vii). In our work as adult educators and as designers of continuing education courses, we routinely refer to the “transformative” impact of our efforts. In this new edition, Cranton includes references to John Dirkx’s (2000) ideas about the role of imagination and spirituality in transformation. Her “guide for adult educators” addresses the power of the affective, as elicited through the use of poetry, music, or the visual arts, to enrich learning—even on topics not obviously arts related. “Any strategy that connects learners to soul work” is to be encouraged, Cranton suggests, echoing Dirkx, who describes this as “critical” to personal transformation (p. 67). A line from “The Dry Salvages,” in T. S. Eliot’s Four Quartets , comes to mind: “We had the experience but missed the meaning / And approach to the meaning restores the experience in a different form. ” In the course of our professional activity, we often experience transformative learning—our own and our students’—without fully appreciating either its source or its meaning. Cranton’s book invites us to reflect on both and, in the process, serves not only as a guide but also as an affirmation of our own best practices.
Haemodynamic and electrophysiological markers of pragmatic language comprehension in schizophrenia

Abstract Objectives. The present study aimed at investigating neurophysiological markers of language perception in schizophrenia using simultaneous near-infrared spectroscopy (NIRS) and event-related potentials (ERPs), which have been proven to be useful for studying language processing abilities in psychiatric patients. The study shall help to integrate previous findings from ERP and fMRI studies on figurative language comprehension in schizophrenia and elucidate how electrophysiological and haemodynamic markers of language processing are related. Methods. Twenty-two healthy subjects and 22 schizophrenia patients judged 120 sentences regarding their meaningfulness. Phrases were literal, metaphoric, or meaningless. EEG-fNIRS signals were recorded throughout the entire experiment. Results. Schizophrenia patients showed deficient and delayed sentence comprehension. Both the early N400 and left-hemispheric activation during language comprehension were altered in patients. Correlation analyses showed that metaphor-related ERPs were strongly linked to haemodynamic cortical activity in healthy subjects, but not in patients. Conclusions. Our results indicate group differences in cortical electrophysiological and haemodynamic activation that represent rather general impairments in the processing of complex language. Simultaneous EEG/NIRS applications are useful to depict these neural markers and to investigate their relationship. Future studies are needed to clarify the nature of respective anomalies and their potential as putative neural markers in schizophrenia research.
References to Named Entities: a Corpus Study

References included in multi-document summaries are often problematic. In this paper, we present a corpus study performed to derive a statistical model for the syntactic realization of referential expressions. The interpretation of the probabilistic data helps us gain insight on how extractive summaries can be rewritten in an efficient manner to produce more fluent and easy-to-read text.
microRNA-622 acts as a tumor suppressor in hepatocellular carcinoma

microRNAs (miRNAs) are important regulators of tumor development and progression. In this study, we aimed to explore the expression and role of miR-622 in hepatocellular carcinoma (HCC). We found that miR-622 was significantly downregulated in human HCC specimens compared to adjacent noncancerous liver tissues. miR-622 downregulation was significantly associated with aggressive parameters and poor prognosis in HCC. Enforced expression of miR-622 significantly decreased the proliferation and colony formation and induced apoptosis of HCC cells. In vivo studies demonstrated that miR-622 overexpression retarded the growth of HCC xenograft tumors. Bioinformatic analysis and luciferase reporter assays revealed that miR-622 directly targeted the 3′-untranslated region (UTR) of mitogen-activated protein 4 kinase 4 (MAP4K4) mRNA. Ectopic expression of miR-622 led to a significant reduction of MAP4K4 expression in HCC cells and xenograft tumors. Overexpression of MAP4K4 partially restored cell proliferation and colony formation and reversed the induction of apoptosis in miR-622-overexpressing HCC cells. Inhibition of JNK and NF-κB signaling phenocopied the anticancer effects of miR-622 on HCC cells. Taken together, miR-622 acts as a tumor suppressor in HCC and restoration of miR-622 may provide therapeutic benefits in the treatment of HCC.
Cross-Sectoral Variation in the Volatility of Plant-Level Idiosyncratic Shocks

We estimate the volatility of plant–level idiosyncratic shocks in U.S. manufacturing. We measure the variation in Revenue Total Factor Productivity not explained by either industry or economy–wide factors, or by establishments’ characteristics. We find that idiosyncratic shocks are much larger than aggregate shocks, accounting for about 80% of the overall uncertainty faced by plants. Plants in the most volatile sector are subject to about six times as much idiosyncratic uncertainty as plants in the least volatile. We provide evidence suggesting that idiosyncratic risk is higher in industries where the extent of creative destruction is likely to be greater.