Miracle-dz/UniFAR-FTUs huggingface dataset:
Genetic Variants Associated with Lipid Profiles in Chinese Patients with Type 2 Diabetes

Dyslipidemia is a strong risk factor for cardiovascular disease among patients with type 2 diabetes (T2D). The aim of this study was to identify lipid-related genetic variants in T2D patients of Han Chinese ancestry. Among 4,908 Chinese T2D patients who were not taking lipid-lowering medications, single nucleotide polymorphisms (SNPs) in seven genes previously found to be associated with lipid traits in genome-wide association studies conducted in populations of European ancestry (ABCA1, GCKR, BAZ1B, TOMM40, DOCK7, HNF1A, and HNF4A) were genotyped. After adjusting for multiple covariates, SNPs in ABCA1, GCKR, BAZ1B, TOMM40, and HNF1A were identified as significantly associated with triglyceride levels in T2D patients (P < 0.05). The associations between the SNPs in ABCA1 (rs3890182), GCKR (rs780094), and BAZ1B (rs2240466) remained significant even after correction for multiple testing (P = 8.85×10−3, 7.88×10−7, and 2.03×10−6, respectively). BAZ1B (rs2240466) also was associated with the total cholesterol level (P = 4.75×10−2). In addition, SNP rs157580 in TOMM40 was associated with the low-density lipoprotein cholesterol level (P = 6.94×10−3). Our findings confirm that lipid-related genetic loci are associated with lipid profiles in Chinese patients with type 2 diabetes.
Rupture of Intracranial Aneurysms during Endovascular Coiling: Management and Outcomes

OBJECTIVEIn this study, the incidence, etiologies, and management with respect to clinical outcome of patients with iatrogenic aneurysmal rupture during attempted coil embolization of intracranial aneurysms are reviewed. METHODSA retrospective analysis was conducted of 274 patients with intracranial aneurysms treated with Guglielmi detachable coils over a 6-year period from 1994 to 2000. Patient medical records were examined for demographic data, aneurysm location, the number of coils deployed preceding and after aneurysmal rupture, the etiology of the rupture, and the clinical status on admission and at the time of discharge. RESULTSOf 274 patients with intracranial aneurysms treated with coil embolization, six (2%) had an intraprocedural rupture. Of these six, two were women and four were men. The mean age was 67 years (range, 52–85 yr). Mean follow-up time was 8 months (range, 0–25 mo). Aneurysmal rupture resulted from detachment of the last coil in three patients, detachment of the third coil (of four) in one patient, and insertion of the first coil in another patient. In one patient, the aneurysmal rupture was a result of catheter advancement before detachment of the last coil. The Glasgow Outcome Scale score at last follow-up examination was 1 in two patients, 2 in two patients, and 5 in two patients. CONCLUSIONThe rate of rupture of aneurysms during coil embolization is approximately 2 to 4%. The clinical outcome may be related to the timing of the rupture and the number of coils placed before rupture. If extravasation of contrast agent is seen, which suggests intraprocedural rupture, further coil deposition should be attempted if safely possible.
Specific olfactory neurons and glomeruli are associated to differences in behavioral responses to pheromone components between two Helicoverpa species

Sex pheromone communication of moths helps to understand the mechanisms underlying reproductive isolation and speciation. Helicoverpa armigera and Helicoverpa assulta use (Z)-11-hexadecenal (Z11-16:Ald) and (Z)-9-hexadecenal (Z9-16:Ald) as pheromone components in reversed ratios, 97:3 and 5:95, respectively. H. armigera also produces trace amount of (Z)-9-tetradecenal (Z9-14:Ald) in the sex pheromone gland, but H. assulta does not. Wind tunnel studies revealed that the addition of small amounts (0.3%) of Z9-14:Ald to the main pheromone blend of H. armigera increased the males' attraction, but at higher doses (1%, 10%) the same compound acted as an inhibitor. In H. assulta, Z9-14:Ald reduced male attraction when presented as 1% to the pheromone blend, but was ineffective at lower concentrations (0.3%). Three types (A–C) of sensilla trichodea in antennae were identified by single sensillum recording, responding to Z11-16:Ald, Z9-14:Ald, and both Z9-16:Ald and Z9-14:Ald, respectively. Calcium imaging in the antennal lobes (ALs) revealed that the input information of the three chemicals was transmitted to three units of the macroglomerular complex (MGC) in ALs in both species: a large glomerulus for the major pheromone components, a small one for the minor pheromone components, and a third one for the behavioral antagonists. The type A and C neurons tuned to Z11-16:Ald and Z9-16:Ald had a reversed target in the MGC between the two species. In H. armigera, low doses (1, 10 μg) of Z9-14:Ald dominantly activated the glomerulus which processes the minor pheromone component, while a higher dose (100 μg) also evoked an equal activity in the antagonistic glomerulus. In H. assulta, instead, Z9-14:Ald always strongly activated the antagonistic glomerulus. These results suggest that Z9-14:Ald plays different roles in the sexual communication of two Helicoverpa species through activation of functionally different olfactory pathways.
Odontoclastogenesis of mouse papilla‐derived MDPC‐23 cells induced by lipopolysaccharide

AIM To investigate the role of Lipopolysaccharide (LPS) in the odontoclast differentiation of MDPC-23 cells. It was hypothesized that MDPC-23 odontoblast-like cells may function as odontoclasts under the influence of LPS. METHODOLOGY MDPC-23 cells were cultured in the presence of 0.1 or 1 μg mL-1 LPS for 6 days. Cell viability was determined using the CCK8 assay. TRAP staining, dentine resorption assay and ROS detection by confocal laser scanning microscope were used to test the odontoclast-like function of the induced cells. In additional, the related protein expression was confirmed by Western blotting and ELISA. An unpaired Student's t-test and one-way anova were used in statistical analysis. RESULTS TRAP-positive cells, which are multinucleated, on the dentine slice were significantly increased in 1 μg mL-1 LPS-induced cells (P < 0.05). Osteoclast-specific proteins such as TRAP cathepsin K and Rac1 were upregulated in the 1 μg mL-1 LPS-treated cells (P < 0.05), whilst the expression of marker proteins of the RANKL-RANK signalling pathway (RANKL, RANK and TRAF6) in the induced cells was not significantly changed (P > 0.05). ROS production was observed in the 1 μg mL-1 LPS treatment group (P < 0.05), but no significant differences were observed in the level of RANKL in the cell supernatant between the LPS-treated group and the control group (P > 0.05). CONCLUSIONS A known value of 1 μg mL-1 LPS might induce odontoblast-like MDPC-23 cells to generate odontoclast-like cells or to function as odontoclasts. The data might provide a new explanation for the precursors of odontoclasts and root resorption.
Should We Screen for Helicobacter pylori to Prevent Gastric Cancer?

Although the strategy for Helicobacter pylori infection management is well defined and quite well followed in a number of situations, including peptic ulcer disease, the issue of H. pylori screening and eradication in the general population still remains. The following debate attempts to find the answer of whether or not H. pylori screening should be performed in the asymptomatic population for preventing gastric cancer. As yet, there is no final evidence-based consensus about the need to screen for H. pylori in order to decrease the incidence of gastric cancer.
The Effects of Internet Access on Contraceptive Use in Indonesia (Intercensal Population Survey Data Analysis of 2015)

The success of family planning program is one of the factors contributing to the decline of fertility rate in Indonesia. Although the prevalence of contraception in Indonesia continues to increase, its growth from year to year continues to decline. Internet is a potential ICT media that can be used to promote family planning program. This study aims to investigate the effect of Internet access on the decision to use contraception in Indonesia. Using data from the Intercensal Population Survey (SUPAS) of 2015, a binary logistic regression is selected to study the effects of Internet access on decision to use contraception among married women aged 15–54 years who live with their partners in Indonesia. The results of this study show that after controlling for education level, working status, place of residence, and age, Internet access statistically makes significant positive effects to the contraceptive use in Indonesia. Keywords—Fertility; contraceptive use; Internet; binary logistic regression; Indonesia.
Prevalence and component analysis of metabolic syndrome: An Indian atherosclerosis research study perspective

Asian Indians have a high predisposition to metabolic syndrome (MS) and coronary artery disease (CAD). The present study aimed to estimate MS prevalence in 531 Asian Indian families comprising of 2318 individuals. Anthropometrics and lipid profile were assessed. MS prevalence was estimated using standard Adult Treatment Panel III (ATP-III) and World Health Organisation (WHO) criteria and modified definitions which included lowered cut-offs for waist circumference (WC) (≥90 cm for men and ≥80 cm for women], body mass index (BMI) (≥23 kg/m2) and impaired fasting glucose (IFG) levels. ATP-III criteria identified a significantly higher proportion of people with MS (N = 933; 40.3%) compared with WHO (N = 708; 30.6%; p < 0.0001) while modified ATP-III showed maximum gain in percent prevalence among the revised criteria (17.3%; p = 0.0056). The IDF criteria identified similar proportion of subjects with MS (N = 809; 34.9%) as the revised WHO criteria (N = 792; 34.2%). The number of MS subjects was highest in the 50–59 years age group. MS was diagnosed a decade earlier in unaffected subjects compared with those with CAD/diabetes using the modified MS criteria. WC correlated significantly with BMI and waist–hip ratio (WHR) (p = 0.000). Among MS components, high density lipoprotein cholesterol and BMI contributed significantly in males (71.4% and 85.9%) and females (86.8% and 88.8%), respectively. The higher percentage contribution of WC among males and WHR among females indicates the influence of gynecoid/android pelvis on WHR measures. In conclusion, the revision of definition criteria for MS with lowered cut-offs for WC and BMI is critical for the accurate assessment of MS among Asian Indians.
Tezepelumab for Severe Asthma: One Drug Targeting Multiple Disease Pathways and Patient Types

Abstract Asthma is a heterogeneous inflammatory disease of the airways, affecting many children, adolescents, and adults worldwide. Up to 10% of people with asthma have severe disease, associated with a higher risk of hospitalizations, greater healthcare costs, and poorer outcomes. Patients with severe asthma generally require high-dose inhaled corticosteroids and additional controller medications to achieve disease control; however, many patients remain uncontrolled despite this intensive treatment. The treatment of severe uncontrolled asthma has improved with greater understanding of asthma pathways and phenotypes as well as the advent of targeted biologic therapies. Tezepelumab, a monoclonal antibody, blocks thymic stromal lymphopoietin, an epithelial cytokine that has multifaceted effects on the initiation and persistence of asthma inflammation and pathophysiology. Unlike other biologic treatments, tezepelumab has demonstrated efficacy across severe asthma phenotypes, with the magnitude of effects varying by phenotype. Here we describe the anti-inflammatory effects and efficacy of tezepelumab across the most relevant phenotypes of severe asthma. Across clinical studies, tezepelumab reduced annualized asthma exacerbation rates versus placebo by 63–71% in eosinophilic severe asthma, by 58–68% in allergic severe asthma, by 67–71% in allergic and eosinophilic severe asthma, by 34–49% in type 2-low asthma, and by 31–41% in oral corticosteroid-dependent asthma. Furthermore, in all these asthma phenotypes, tezepelumab demonstrated higher efficacy in reducing exacerbations requiring hospitalizations or emergency department visits versus placebo. In patients with severe uncontrolled asthma, who commonly have multiple drivers of inflammation and disease, tezepelumab may modulate airway inflammation more extensively, as other available biologics block only specific downstream components of the inflammatory cascade.
Why do smallholder farmers dis‐adopt conservation agriculture? Insights from Malawi

International donors and advisory bodies, governments, and nongovernmental organisations are actively promoting conservation agriculture (CA) to improve agricultural productivity and resilience to climate change impacts. However, many smallholder farmers continue to dis‐adopt (abandon) the technology. Reasons for dis‐adoption are not well known. This article examines farmers' lived experiences and perceptions of CA to understand why smallholder farmers dis‐adopt CA in Malawi. Improving understanding of dis‐adoption of this seemingly appropriate intervention is important to achieve sustained adoption and for ensuring long‐lasting impacts of agricultural development project interventions. A mixed methods approach was used, involving household questionnaire survey and focus group discussions with smallholder farmers. Findings reveal that although drivers of dis‐adoption are multidimensional and multilayered, they are rooted in shortfalls of CA promoters' implementation arrangements. Although CA proponents market CA as a time‐saving, labour‐saving, and yield‐improving technology, respondents report contrary experiences. Our findings show that farmers lack sufficient technical support and encounter technological, social, institutional, and economic challenges. These, coupled with unfulfilled expectations, undermine ownership of CA projects and lead to dis‐adoption. This highlights a need to (a) collaboratively design projects to better suit local needs and context with inclusive implementation arrangements; (b) emphasise climate resilience benefits of CA rather than economic benefits to manage farmers' expectations; (c) intensify multidisciplinary research that incorporates farmers' knowledge and experiences to develop suitable, flexible, and low‐input CA packages; and (d) provide regular hands‐on technical extension support to farmers.
Vitamin D Supplementation Affects Serum High-Sensitivity C-Reactive Protein , Insulin Resistance , and Biomarkers of Oxidative Stress in Pregnant Women 1 , 2

Unfavorable metabolic profiles and oxidative stress in pregnancy are associated with several complications. This study was conducted to determine the effects of vitamin D supplementation on serum concentrations of high-sensitivity C-reactive protein (hs-CRP), metabolic profiles, and biomarkers of oxidative stress in healthy pregnant women. This randomized, double-blind, placebo-controlled clinical trial was conducted in 48 pregnant women aged 18–40 y old at 25 wk of gestation. Participants were randomly assigned to receive either 400 IU/d cholecalciferol supplements (n = 24) or placebo (n = 24) for 9 wk. Fasting blood samples were taken at study baseline and after 9 wk of intervention to quantify serum concentrations of hs-CRP, lipid concentrations, insulin, and biomarkers of oxidative stress. After 9 wk of intervention, the increases in serum 25-hydroxyvitamin D and calcium concentrations were greater in the vitamin D group (+3.7 mg/L and +0.20 mg/dL, respectively) than in the placebo group (21.2 mg/L and 20.12 mg/dL, respectively; P < 0.001 for both). Vitamin D supplementation resulted in a significant decrease in serum hs-CRP (vitamin D vs. placebo groups: 21.41 vs. +1.50 mg/mL; P-interaction = 0.01) and insulin concentrations (vitamin D vs. placebo groups: 21.0 vs. +2.6 mIU/mL; P-interaction = 0.04) and a significant increase in the Quantitative Insulin Sensitivity Check Index score (vitamin D vs. placebo groups: +0.02 vs. 20.02; P-interaction = 0.006), plasma total antioxidant capacity (vitamin D vs. placebo groups: +152 vs. 220 mmol/L; P-interaction = 0.002), and total glutathione concentrations (vitamin D vs. placebo groups: +205 vs. 232 mmol/L; Pinteraction = 0.02) compared with placebo. Intake of vitamin D supplements led to a significant decrease in fasting plasma glucose (vitamin D vs. placebo groups:20.65 vs.20.12mmol/L; P-interaction = 0.01), systolic blood pressure (vitamin D vs. placebo groups: 20.2 vs. +5.5 mm Hg; P-interaction = 0.01), and diastolic blood pressure (vitamin D vs. placebo groups: 20.4 vs. +3.1 mm Hg; P-interaction = 0.01) compared with placebo. In conclusion, vitamin D supplementation for 9 wk among pregnant women has beneficial effects on metabolic status. J. Nutr. 143: 1432–1438, 2013.
When a friend in Twitter is a friend in life

Twitter is a fast-growing online social network service (SNS) where users can "follow" any other user to receive his or her mini-blogs which are called "tweets". In this paper, we study the problem of identifying a user's off-line real-life social community, which we call the user's Twitter off-line community, purely from examining Twitter network structure. Based on observations from our user-verified Twitter data and results from previous works, we propose three principles about Twitter off-line communities. Incorporating these principles, we develop a novel algorithm to iteratively discover the Twitter off-line community based on a new way of measuring user closeness. According to ground truth provided by real Twitter users, our results demonstrate the effectiveness of our approach with both high precision and recall in most cases.
The impact of the bladder wall thickness on the outcome of the medical treatment using alpha-blocker of BPH patients with LUTS

Abstract Objectives: To evaluate whether the outcome of medical treatment with α 1 receptor blocker in Benign prostatic hyperplasia (BPH) patients with lower urinary tract symptoms (LUTS) is affected by the bladder wall thickness (BWT) Methods: A total of 125 male BPH patients with LUTS were enrolled. All patients were assessed using The International Prostatic Symptom Score (IPSS), prostate specific antigen (PSA), prostate volume, uroflowmetry, post voiding residual (PVR). BWT was measured by Trans-abdominal ultrasound, and patients were divided into two groups group 1 (patients with BWT <5 mm) and group 2 (patients with BWT ≥5 mm). The patients were reassessed after 2 months of treatment with α 1 receptor blocker (alfuzosin 10 mg). Clinical parameters were analyzed and compared between groups. Results: There were significant difference between both groups as regard IPSS, voiding symptoms, and storage symptoms (p = 0.005), (p = 0.010) and (p = 0.041) respectively. After medication, there were improvements in the total IPSS, voiding symptoms, storage symptoms, Qmax, PVR and Qol in both groups and these improvements were more effectively in (group 1) than (group 2) with statistically significant differences (p < 0.05). Conclusion: BWT has positive correlation with the total IPSS, voiding symptoms subscores and storage symptoms subscores. The response to medical treatment is found statistically less in patients with BWT greater than 5 mm.
Amplification, cloning, and sequencing of a nifH segment from aquatic microorganisms and natural communities

By use of the polymerase chain reaction and degenerate oligonucleotide primers for highly conserved regions of nifH, a segment of nifH DNA was amplified from several aquatic microorganisms, including an N2-fixing bacterium closely associated with the marine filamentous cyanobacterium Trichodesmium sp. , a heterotrophic isolate from the root/rhizome of the seagrass Ruppia maritima, and the heterocystous freshwater cyanobacterium Anabaena oscillarioides. nifH segments were amplified directly from DNA extracted from the rhizosphere of roots of the seagrass Halodule wrightii. The nifH fragments were then cloned and sequenced. The DNA and deduced amino acid sequences were compared with known sequences, revealing distinct differences between taxonomic groups. This technique was shown to be useful for (i) the detection of N2-fixing microorganisms and (ii) rapidly obtaining the DNA sequence of the nifH gene, which provides information about general taxonomic groups of N2-fixing microorganisms.
Performance testing of combinatorial solvers with isomorph class instances

Combinatorial optimization problems expressed as Boolean constraint satisfaction problems (BCSPs) arise in several contexts, ranging from the classical unate set-packing problems to the binate minimum cover problems, including the Haplotype Inference by Pure Parsimony (HIPP) problem. These problems are being solved under different formulations and in different formats. Results of experiments that are reported can be seldom compared and replicated. This paper is not about 'the best BCSP solver'. Rather, it is a case study of how the scientific method can be applied to comparing the performance of not only BCSP solvers but also other solvers that address NP-hard problems. The approach is founded on two premises: (1) the introduction of instance isomorphs as families of equivalence classes, based on randomized replicas of a given reference instance, and (2) the use of isomorph classes for the design of reproducible experiments with BCSP solvers that includes performance testing hypotheses. We introduce a number of BCSP reference instances from different domains, generate isomorph classes and use various versions of cplex to characterize the solver performance and the isomorph classes themselves. This methodology may make it easier to (1) reliably improve the performance of combinatorial solvers and, (2) report results of experiments under the proposed schema.
Controlled Release of Bevacizumab Through Nanospheres for Extended Treatment of Age-Related Macular Degeneration

Bevacizumab (Avastin®) has been used by ophthalmologists in many countries as an off-label drug for the treatment of wet age-related macular degeneration (AMD). Due to its short half-life necessitating frequent intravitreal injection, a method for sustained delivery is in need. We demonstrated that bevacizumab could be released in a sustained fashion over 90 days from nano- and microspheres fabricated from poly(DL-lactide-co-glycolide) and poly(ethylene glycol)-b-poly(D,L-lactic acid), respectively. The drug release rate could be adjusted by alteration of the drug/polymer ratio. The use of such nano- and microspheres as bevacizumab delivery vehicles may improve the treatment of wet AMD.
Detecting spammers on social networks

Social networking has become a popular way for users to meet and interact online. Users spend a significant amount of time on popular social network platforms (such as Facebook, MySpace, or Twitter), storing and sharing a wealth of personal information. This information, as well as the possibility of contacting thousands of users, also attracts the interest of cybercriminals. For example, cybercriminals might exploit the implicit trust relationships between users in order to lure victims to malicious websites. As another example, cybercriminals might find personal information valuable for identity theft or to drive targeted spam campaigns. In this paper, we analyze to which extent spam has entered social networks. More precisely, we analyze how spammers who target social networking sites operate. To collect the data about spamming activity, we created a large and diverse set of "honey-profiles" on three large social networking sites, and logged the kind of contacts and messages that they received. We then analyzed the collected data and identified anomalous behavior of users who contacted our profiles. Based on the analysis of this behavior, we developed techniques to detect spammers in social networks, and we aggregated their messages in large spam campaigns. Our results show that it is possible to automatically identify the accounts used by spammers, and our analysis was used for take-down efforts in a real-world social network. More precisely, during this study, we collaborated with Twitter and correctly detected and deleted 15,857 spam profiles.