Miracle-dz/UniFAR-FTUs huggingface dataset:
Outcome in emotionally related living kidney donor transplantation.

BACKGROUND The growing shortage of cadaver kidneys, the limited possibilities to expand the living related donor pool and the good results obtained in our centre with poorly matched cadaver kidneys, led us in 1991 to begin accepting highly motivated, unrelated, living kidney donors who had a strong emotional bond with the recipients. METHODS Between 1 January 1991 and 1 January 1996, 46 potential living kidney donors and their emotionally related recipients were evaluated. Twenty-three cases were accepted for renal transplantation after thorough somatic and psychological evaluation. The mean post-transplant follow-up until 1 April 1996 was of 28 +/- 3 months. Compatible blood groups and a negative cross-match were mandatory, but no minimal HLA matching was required. RESULTS There was a 50% drop-out rate following the initial screening. The main reasons for not performing transplantation were immunological contraindications in 39% of the cases, somatic in 30.5%, psychological in 26% and socioeconomic in 4.5%. In the accepted group of recipients, 48% (11/23) received transplants without chronic dialysis. Donor survival was 91%; two deaths unrelated to nephrectomy occurred 1 year after donation. The 2-year actuarial recipient and graft survivals were 100% and 91% respectively, compared to 99% (recipients) and 93% (grafts) in the non-HLA-identical living related kidney transplant group, and to 93% (recipients) and 83% (grafts) in the cadaver kidney transplant group. Recipient rehabilitation was completed after 4 +/- 1 months. Emotionally related donors returned to work 5 +/- 2 weeks after nephrectomy, and no donor regretted his decision, even in the case of failure. CONCLUSIONS Kidney transplantation from emotionally related living donors represents a valuable option, allowing more patients with end-stage renal disease to avoid chronic dialysis. Recipient and graft outcomes were superior to cadaver kidney transplantation. Motivated and emotionally related donors should be allowed to donate one of their kidneys provided that they are carefully selected and thoroughly informed.
Targeting FMS‐related tyrosine kinase receptor 3 with the human immunoglobulin G1 monoclonal antibody IMC‐EB10

FMS‐related tyrosine kinase receptor 3 (FLT3) is a class III receptor tyrosine kinase that holds considerable promise as a therapeutic target in hematologic malignancies. Current efforts directed toward the development of small‐molecule tyrosine kinase inhibitors of FLT3 may be limited by off‐target toxicities and the development of drug resistance. Target‐specific antibodies could overcome these hurdles and provide additional mechanisms to enhance the antitumor efficacy of FLT3 inhibitors. IMC‐EB10 is a novel antibody directed against FLT3. The binding of IMC‐EB10 to FLT3 results in antiproliferative effects in vitro and in mouse models engrafted with human leukemia cells that harbor wild‐type or constitutively activated FLT3. Future clinical trials will test these notions formally and will identify the most appropriate opportunities for this member of a new generation of antileukemic therapies. Cancer 2010;116(4 suppl):1013–7. © 2010 American Cancer Society.
Comparative study between transanal tube and loop ileostomy in low anterior resection for mid rectal cancer: a retrospective single center trial

Purpose To investigate the efficacy and safety of the transanal tube (TAT) in preventing anastomotic leak (AL) in rectal cancer surgery. Methods Clinical data of the patients who underwent curative surgery for mid rectal cancer from February 2010 to February 2014 were reviewed retrospectively. Rectal cancers arising 5 to 10 cm above the anal verge were selected. Patients were divided into the ileostomy, TAT, or no-protection groups. Postoperative complications including AL and postoperative course were compared. Results We included 137 patients: 67, 35, and 35 patients were included in the ileostomy, TAT, and no-protection groups, respectively. Operation time was longer in the ileostomy group (P = 0.029), and more estimated blood loss was observed (P = 0.018). AL occurred in 5 patients (7.5%) in the ileostomy group, 1 patients (2.9%) in the TAT group, and 6 patients (17.1%) in the no-protection group (P = 0.125). Patients in the ileostomy group resumed diet more than 1 day earlier than those in the other groups (P = 0.000). Patients in the no-protection group had about 1 or 2 days longer postoperative hospital stay (P = 0.048). The ileostomy group showed higher late complication rates than the other groups as complications associated with the stoma itself or repair operation developed (P = 0.019). Conclusion For mid rectal cancer surgery, the TAT supports anastomotic site protection and diverts ileostomy-related complications. Further large scale randomized controlled studies are needed to gain more evidence and expand the range of TAT usage.
Timing of adrenal regression controlled by synergistic interaction between Sf1 SUMOylation and Dax1

The nuclear receptor steroidogenic factor 1 (Sf1, Nr5a1, Ad4bp) is crucial for formation, development and function of steroidogenic tissues. A fetal adrenal enhancer (FAdE) in the Sf1 gene was previously identified to direct Sf1 expression exclusively in the fetal adrenal cortex and is bound by both Sf1 and Dax1. Here, we have examined the function of Sf1 SUMOylation and its interaction with Dax1 on FAdE function. A diffused prolonged pattern of FAdE expression and delayed regression of the postnatal fetal cortex (X-zone) were detected in both the SUMOylation-deficient-Sf12KR/2KR and Dax1 knockout mouse lines, with FAdE expression/activity retained in the postnatal 20αHSD-positive postnatal X-zone cells. In vitro studies indicated that Sf1 SUMOylation, although not directly influencing DNA binding, actually increased binding of Dax1 to Sf1 to further enhance transcriptional repression of FAdE. Taken together, these studies define a crucial repressor function of Sf1 SUMOylation and Dax1 in the physiological cessation of FAdE-mediated Sf1 expression and the resultant regression of the postnatal fetal cortex (X-zone). Summary: Lack of Sf1 SUMOylation and the genetic loss of Dax1 both cause extended activation of the fetal adrenoceptor enhancer of Sf1 and delayed regression of the postnatal fetal cortex (X-zone) in mouse adrenals.
Oxytocin modulates fMRI responses to facial expression in macaques

Significance Oxytocin (OT), a mammalian hormone, may serve as a treatment for psychiatric disorders because of its beneficial effect on social behavior. Here, we found that in monkeys, OT selectively altered brain activity within multiple neural systems (visual perception, emotion, attention, and higher cognition function) and functional coupling between the amygdala and areas in the ventral visual pathway evoked by negative emotional expressions. Our findings provide key information for understanding the behavioral consequences of OT administration and indicate homologies between monkeys and humans in the neural circuits mediating the effects of OT. Thus, the monkey may be an ideal animal model to explore the development of OT-based pharmacologic strategies for treating patients with dysfunctional social behavior. Increasing evidence has shown that oxytocin (OT), a mammalian hormone, modifies the way social stimuli are perceived and the way they affect behavior. Thus, OT may serve as a treatment for psychiatric disorders, many of which are characterized by dysfunctional social behavior. To explore the neural mechanisms mediating the effects of OT in macaque monkeys, we investigated whether OT would modulate functional magnetic resonance imaging (fMRI) responses in face-responsive regions (faces vs. blank screen) evoked by the perception of various facial expressions (neutral, fearful, aggressive, and appeasing). In the placebo condition, we found significantly increased activation for emotional (mainly fearful and appeasing) faces compared with neutral faces across the face-responsive regions. OT selectively, and differentially, altered fMRI responses to emotional expressions, significantly reducing responses to both fearful and aggressive faces in face-responsive regions while leaving responses to appeasing as well as neutral faces unchanged. We also found that OT administration selectively reduced functional coupling between the amygdala and areas in the occipital and inferior temporal cortex during the viewing of fearful and aggressive faces, but not during the viewing of neutral or appeasing faces. Taken together, our results indicate homologies between monkeys and humans in the neural circuits mediating the effects of OT. Thus, the monkey may be an ideal animal model to explore the development of OT-based pharmacological strategies for treating patients with dysfunctional social behavior.
Three new species of the killifish genus Melanorivulus from the Rio Paraná Basin, central Brazilian Cerrado (Cyprinodontiformes, Aplocheilidae)

Three new species of Melanorivulus are described from the upper and middle Rio Paraná Basin, central Brazilian Cerrado. These species are members of the M. pictus species group, endemic to central Brazilian plateaus and adjacent areas, and are easily diagnosed by colour pattern characters, but their relationships with other congeners of the group are still uncertain. Melanorivulus proximus sp. n. , from the middle Rio Aporé drainage, and M. nigromarginatus sp. n. , from the Rio Corrente drainage, are possibly more closely related to other species endemic to streams draining the slopes of the Caiapó range, whereas M. linearis sp. n. , from the upper Rio Pardo drainage, middle Rio Paraná Basin, is considered more closely related to M. egens, a species also endemic to this part of the Basin. This study corroborates the high diversity of species of Melanorivulus in the central Brazilian Cerrado plateaus repeatedly reported in previous studies, indicating once more that different species are often found restricted to short segments of the same river drainage. The intense habitat loss recorded in recent years combined to the high species diversity limited to specific Cerrado freshwater ecosystems, the veredas, indicates that species of Melanorivulus endemic to this part of the Brazilian Cerrado are highly threatened with extinction.
Sexual risk behaviour among people living with HIV according to the biomedical risk of transmission: results from the ANRS-VESPA2 survey

People living with HIV (PLHIV) on antiretroviral therapy (ART), with sustained undetectable viral load (sUVL) and no history of sexually transmitted infections for at least six months, are considered to have a low risk of HIV transmission (LRT). We aimed to characterize, in a representative sample of French PLHIV, the sexual behaviour of LRT PLHIV compared with non‐LRT PLHIV.
Sustained response with ixekizumab treatment of moderate-to-severe psoriasis with scalp involvement: results from three phase 3 trials (UNCOVER-1, UNCOVER-2, UNCOVER-3)

Abstract Background: Scalp is a frequently affected and difficult-to-treat area in psoriasis patients. Objective: We assessed the efficacy of ixekizumab in the treatment of patients with scalp psoriasis over 60 weeks using the Psoriasis Scalp Severity Index (PSSI). Methods: In three Phase 3, multicenter, double-blind, placebo-controlled trials, patients with moderate-to-severe psoriasis in UNCOVER-1 (N = 1296), UNCOVER-2 (N = 1224) and UNCOVER-3 (N = 1346) were randomized to subcutaneous 80 mg ixekizumab every two weeks (Q2W) or every four weeks (Q4W) after a 160 mg starting dose, or placebo through Week 12. Additional UNCOVER-2 and UNCOVER-3 cohorts were randomized to 50 mg bi-weekly etanercept through Week 12. Patients entering the open-label long-term extension (LTE) (UNCOVER-3) received ixekizumab Q4W; UNCOVER-1 and UNCOVER-2 included a blinded maintenance period in which static physician global assessment (sPGA) 0/1 responders were re-randomized to placebo, ixekizumab Q4W, or 80 mg ixekizumab every 12 weeks (Q12W) through Week 60. Results: In patients with moderate-to-severe psoriasis with baseline scalp involvement, PSSI 90 and 100 were achieved at Week 12 in higher percentages of patients treated with ixekizumab Q2W (81.7% and 74.6%) or ixekizumab Q4W (75.6% and 68.9%) compared with patients treated with placebo (7.6% and 6.7%; p < .001 each ixekizumab arm versus placebo) or etanercept (55.5% and 48.1%; p < .001 each ixekizumab arm versus etanercept). These outcomes were maintained through Week 60 of the maintenance (UNCOVER-1 and UNCOVER-2) and LTE (UNCOVER-3) period in patients who continued on ixekizumab Q4W. Conclusion: Ixekizumab was efficacious in treating scalp psoriasis in patients with moderate-to-severe psoriasis, with most patients achieving complete or near-complete resolution of scalp psoriasis and maintaining this response over 60 weeks.
Association between anxiety and hypertension: a systematic review and meta-analysis of epidemiological studies

Background Epidemiological studies have repeatedly investigated the association between anxiety and hypertension. However, the results have been inconsistent. This study aimed to summarize the current evidence from cross-sectional and prospective studies that evaluated this association. Methods Seven common databases were searched for articles published up to November 2014. Cross-sectional and prospective studies that reported an association between the two conditions in adults were included. Data on prevalence, incidence, unadjusted or adjusted odds ratios or hazard ratios, and 95% confidence intervals (CIs) were extracted or calculated by the authors. The pooled odds ratio was calculated separately for cross-sectional and prospective studies using random-effects models. The Q test and I 2 statistic was used to assess heterogeneity. A funnel plot and modified Egger linear regression test were used to estimate publication bias. Results The search yielded 13 cross-sectional studies (n=151,389), and the final pooled odds ratio was 1.18 (95% CI 1.02–1.37; PQ<0.001; I2=84.9%). Eight prospective studies with a total sample size of 80,146 and 2,394 hypertension case subjects, and the pooled adjusted hazard ratio was 1.55 (95% CI 1.24–1.94; PQ<0.001; I2=84.6%). The meta-regression showed that location, diagnostic criteria for anxiety, age, sex, sample size, year of publication, quality, and years of follow-up (for prospective study) were not sources of heterogeneity. Conclusion Our results suggest that there is an association between anxiety and increased risk of hypertension. These results support early detection and management of anxiety in hypertensive patients.
A hybrid feature selection strategy for image defining features: towards interpretation of optic nerve images

Modern imaging techniques such as confocal scanning laser tomography (CSLT) capture high-quality optic nerve images. The automated analysis of CSLT images, by combining image processing and data mining methods, offers the potential for developing objective methods for supporting clinical decision-making in glaucoma. We present our approach that involves the analysis of CSLT images using moment methods to derive abstract image defining features, and then the use of these features to train classifiers for automatically distinguishing CSLT images of healthy and diseased optic nerves. As a first step, in this paper, we present investigations in feature subset selection methods for reducing the relatively large input space produced by the moment methods. Our results demonstrate that our methods can discriminate between healthy and glaucomatous optic nerves based on shape information automatically derived from CSLT tomography images.
Fault-Tolerant Networks for Electronic Textiles

Given the dynamic and harsh environments of electronic textile applications, particularly wearable computers and large-scale sensor networks, fault-tolerance is necessary. The interconnection network should route around faults in communication links and processing nodes. The mechanisms of error detection and route change decisions will be presented. Simulation results of the full network are reported.
Beyond ideal MHD: towards a more realistic modelling of relativistic astrophysical plasmas

Many astrophysical processes involving magnetic fields and quasi-stationary processes are well described when assuming the fluid as a perfect conductor. For these systems, the idealmagnetohydrodynamics (MHD) description captures the dynamics effectively and a number of well-tested techniques exist for its numerical solution. Yet, there are several astrophysical processes involving magnetic fields which are highly dynamical and for which resistive effects can play an important role. The numerical modelling of such non-ideal MHD flows is significantly more challenging as the resistivity is expected to change of several orders of magnitude across the flow and the equations are then either of hyperbolic‐parabolic nature or hyperbolic with stiff terms. We here present a novel approach for the solution of these relativistic resistive MHD equations exploiting the properties of implicit‐explicit (IMEX) Runge‐Kutta methods. By examining a number of tests, we illustrate the accuracy of our approach under a variety of conditions and highlight its robustness when compared with alternative methods, such as the Strang splitting. Most importantly, we show that our approach allows one to treat, within a unified framework, those regions of the flow which are both fluid-pressure dominated (such as in the interior of compact objects) and instead magnetic-pressure dominated (such as in their magnetospheres). In view of this, the approach presented here could find a number of applications and serve as a first step towards a more realistic modelling of relativistic astrophysical plasmas.
Effects of Hypothermia on Energy Metabolism in Mammalian Central Nervous System

This review analyzes, in some depth, results of studies on the effect of lowered temperatures on cerebral energy metabolism in animals under normal conditions and in some selected pathologic situations. In sedated and paralyzed mammals, acute uncomplicated 0.5- to 3-h hypothermia decreases the global cerebral metabolic rate for glucose (CMRglc) and oxygen (CMRO2) but maintains a slightly better energy level, which indicates that ATP breakdown is reduced more than its synthesis. Intracellular alkalinization stimulates glycolysis and independently enhances energy generation. Lowering of temperature during hypoxia–ischemia slows the rate of glucose, phosphocreatine, and ATP breakdown and lactate and inorganic phosphate formation, and improves recovery of energetic parameters during reperfusion. Mild hypothermia of 12 to 24-h duration after normothermic hypoxic–ischemic insults seems to prevent or ameliorate secondary failures in energy parameters. The authors conclude that lowered head temperatures help to protect and maintain normal CNS function by preserving brain ATP supply and level. Hypothermia may thus prove a promising avenue in the treatment of stroke and trauma and, in particular, of perinatal brain injury.
Inpainting Assisted Self Recovery With Decreased Embedding Data

When hiding information in an image for self recovery, the amount of embedding data affects the embedding influence and the recovery quality. The purpose of this paper is to reduce the amount of embedding data while maintaining good recovery quality. We propose an approach to generate reference data from the original image by encoding different types of blocks into different number of bits. In reconstructing the reference image, a fast inpainting method is used to recover the contents of corrupted regions accompanied with the extracted bits.
Clinical information systems and the electronic medical record in the intensive care unit

The integration of computers into critical care is by no means a new concept. Clinical information systems have evolved in the critical care setting over the past three decades. Their use by critical care healthcare providers has increased exponentially in the past few years. More recently, with the advent of the electronic medical record, clinicians in the ICU may obtain and share useful information both bedside and remotely. Clinical information systems and the electronic medical record in the ICU have the potential to improve medical record movement problems, to improve quality and coherence of the patient care process, to automate guidelines and care pathways, and to assist in clinical care and research, outcome management, and process improvement. In this article, we provide some historical background on the clinical information system and the electronic medical record and describe their current utilization in the ICU and their role in the practice of critical care medicine in decades to come.
The Novel Organic Arsenical Darinaparsin Induces MAPK-Mediated and SHP1-Dependent Cell Death in T-cell Lymphoma and Hodgkin Lymphoma Cells and Human Xenograft Models

Purpose: Darinaparsin (Zio-101) is a novel organic arsenical compound with encouraging clinical activity in relapsed/refractory T-cell lymphoma (TCL) and Hodgkin lymphoma (HL); however, little is known about its mechanism of action. Experimental Design: TCL cell lines (Jurkat, Hut78, and HH) and HL cell lines (L428, L540, and L1236) were examined for in vitro cell death by MTT assay and Annexin V–based flow cytometry. Jurkat and L540-derived xenografts in SCID mice were examined for in vivo tumor inhibition and survival. Biologic effects of darinaparsin on the MAPK pathway were investigated using pharmacologic inhibitors, RNAi and transient transfection for overexpression for SHP1 and MEK. Results: Darinaparsin treatment resulted in time- and dose-dependent cytotoxicity and apoptosis in all TCL and HL cell lines. In addition, darinaparsin had more rapid, higher, and sustained intracellular arsenic levels compared with arsenic trioxide via mass spectrometry. In vivo experiments with Jurkat (TCL) and L540 (HL)-derived lymphoma xenografts showed significant inhibition of tumor growth and improved survival in darinaparsin-treated SCID mice. Biologically, darinaparsin caused phosphorylation of ERK (and relevant downstream substrates) primarily by decreasing the inhibitory SHP1 phosphatase and coimmunoprecipitation showed significant ERK/SHP1 interaction. Furthermore, ERK shRNA knockdown or constitutive overexpression of SHP1 resulted in increased apoptosis, whereas cotreatment with pharmacologic MEK inhibitors resulted in synergistic cell death. Conversely, SHP1 blockade (via pharmacologic inhibition or RNAi) and MEK constitutive activation decreased darinaparsin-related cell death. Conclusions: Altogether, these data show that darinaparsin is highly active in HL and TCL and its activity is dependent primarily on MAPK mechanisms. Clin Cancer Res; 20(23); 6023–33. ©2014 AACR.