Miracle-dz/UniFAR-FTUs huggingface dataset:
Detection of cognitive impairment in the elderly by general internists in Brazil

BACKGROUND: Cognitive impairment, from mild forms to dementia, is an important social and health concern, principally among older individuals. Elderly patients are usually followed by general internists, who may overlook this condition. OBJECTIVE: Our aim was to determine whether cognitive impairment diagnosed by specialists had been previously detected by general internists. SUBJECTS AND METHODS: A total of 248 elderly individuals randomly selected from a list of outpatients seen by general internists in a public university hospital in São Paulo, Brazil, were evaluated by a geriatrician. Patients were then classified as having probable cognitive impairment or not, based on their performance on the Mini-Mental State Examination and the Informant Questionnaire on Cognitive Decline in the Elderly. Cases of probable impairment were submitted to routine laboratory investigation, brain computed tomography, and neuropsychological evaluation. The final diagnoses were established by a consensus panel comprising two neurologists and the geriatrician who evaluated the patients using all available data. General internists' files for all cognitively impaired cases and for a selected sample of individuals without cognitive impairment were checked for any record of cognitive complaints or decline. RESULTS: Forty-three patients were classified as demented (n = 21) or as cognitively impaired but not demented (n = 22). The evaluation of the general internists' files revealed that information on cognitive complaints or decline was recorded for seven (16.3%) of the 43 patients with dementia or cognitive impairment without dementia. CONCLUSIONS: General internists seldom detected cognitive decline in elderly patients in Brazil. Further studies should be conducted to elucidate the reasons for this low rate of detection.
One-loop energy-momentum tensor in QED with electriclike background

We have obtained nonperturbative one-loop expressions for the mean-energy-momentum tensor and current density of Dirac's field on a constant electriclike background. One of the goals of this calculation is to give a consistent description of backreaction in such a theory. Two cases of initial states are considered: the vacuum state and the thermal equilibrium state. First, we perform calculations for the vacuum initial state. In the obtained expressions, we separate the contributions due to particle creation and vacuum polarization. The latter contributions are related to the Heisenberg-Euler Lagrangian. Then, we study the case of the thermal initial state. Here, we separate the contributions due to particle creation, vacuum polarization, and the contributions due to the work of the external field on the particles at the initial state. All these contributions are studied in detail, in different regimes of weak and strong fields and low and high temperatures. The obtained results allow us to establish restrictions on the electric field and its duration under which QED with a strong constant electric field is consistent. Under such restrictions, one can neglect the backreaction of particles created by the electric field. Some of the obtained results generalize the calculations of Heisenberg-Euler for energymore » density to the case of arbitrary strong electric fields. « less
Hepatitis C Virus p7 is Critical for Capsid Assembly and Envelopment

Hepatitis C virus (HCV) p7 is a membrane-associated ion channel protein crucial for virus production. To analyze how p7 contributes to this process, we dissected HCV morphogenesis into sub-steps including recruitment of HCV core to lipid droplets (LD), virus capsid assembly, unloading of core protein from LDs and subsequent membrane envelopment of capsids. Interestingly, we observed accumulation of slowly sedimenting capsid-like structures lacking the viral envelope in cells transfected with HCV p7 mutant genomes which possess a defect in virion production. Concomitantly, core protein was enriched at the surface of LDs. This indicates a defect in core/capsid unloading from LDs and subsequent membrane envelopment rather than defective trafficking of core to this cellular organelle. Protease and ribonuclease digestion protection assays, rate zonal centrifugation and native, two dimensional gel electrophoresis revealed increased amounts of high-order, non-enveloped core protein complexes unable to protect viral RNA in cells transfected with p7 mutant genomes. These results suggest accumulation of capsid assembly intermediates that had not yet completely incorporated viral RNA in the absence of functional p7. Thus, functional p7 is necessary for the final steps of capsid assembly as well as for capsid envelopment. These results support a model where capsid assembly is linked with membrane envelopment of nascent RNA-containing core protein multimers, a process coordinated by p7. In summary, we provide novel insights into the sequence of HCV assembly events and essential functions of p7.
Incentive Contracts in Delegated Portfolio Management

This paper analyzes optimal non-linear portfolio management contracts. We consider a setting where the investor faces moral hazard with respect to the effort and risk choices of the portfolio manager. The manager's employment contract promises her: (a) a fixed payment, (b) a proportional asset-based fee, (c) a benchmark-linked fulcrum fee, and (d) a benchmark-linked option-type bonus incentive fee. We show that the option-type incentive helps overcome the effort-underinvestment problem that undermines linear contracts. More generally, we find that for the set of contracts we consider, with the appropriate choice of benchmark it is always optimal to include a bonus incentive fee in the contract. We derive the conditions that such a benchmark must satisfy. Our results suggest that current regulatory restrictions on asymmetric performance-based fees in mutual fund advisory contracts may be costly.
Death Receptor 6 Induces Apoptosis Not through Type I or Type II Pathways, but via a Unique Mitochondria-dependent Pathway by Interacting with Bax Protein*

Background: DR6-induced apoptosis mechanism is unknown. Results: DR6-induced apoptosis is dependent on cytochrome c release and Bax translocation, but is independent of caspase-8 and Bid. Conclusion: DR6-induced apoptosis is mediated by a unique pathway, different from type I and type II pathways. Significance: This study will lead to a better understanding of the mechanism by which DR6 induces apoptosis. Cells undergo apoptosis through two major pathways, the extrinsic pathway (death receptor pathway) and the intrinsic pathway (the mitochondrial pathway). These two pathways can be linked by caspase-8-activated truncated Bid formation. Very recently, death receptor 6 (DR6) was shown to be involved in the neurodegeneration observed in Alzheimer disease. DR6, also known as TNFRSF21, is a relatively new member of the death receptor family, and it was found that DR6 induces apoptosis when it is overexpressed. However, how the death signal mediated by DR6 is transduced intracellularly is not known. To this end, we have examined the roles of caspases, apoptogenic mitochondrial factor cytochrome c, and the Bcl-2 family proteins in DR6-induced apoptosis. Our data demonstrated that Bax translocation is absolutely required for DR6-induced apoptosis. On the other hand, inhibition of caspase-8 and knockdown of Bid have no effect on DR6-induced apoptosis. Our results strongly suggest that DR6-induced apoptosis occurs through a new pathway that is different from the type I and type II pathways through interacting with Bax.
Teacher Performance Pay: Synthesis of Plans, Research, and Guidelines for Practice. Policy Brief RB-46.

The single salary schedule has ruled the delivery of teacher pay for decades, despite long-standing criticism that it fails to link some portion of teachers'pay to their performance. In recent years, there has been some experimentation with performance pay for teachers. Early attempts focused on the development of merit pay, in which pay raises were linked to subjective evaluations of teacher performance. Subsequent evaluations of merit pay plans questioned their effectiveness, especially given their limited survival, though it was acknowledged that the problem was not necessarily merit pay per se, but the way the plans were designed, implemented, and administered (Hatry, Greiner, & Ashford, 1994). Notwithstanding these unsuccessful experiences, national surveys have found that teacher attitudes toward some forms of performance pay are not unfavorable (Ballou, 2001; Ballou & Podgursky, 1993). In the 1990s, other forms of performance pay began to emerge at the state and district levels. Notable were school-based performance awards and knowledgeand skill-based pay plans. Elements from these plans have now been incorporated into combined pay plans. And while none of these plans has been widely adopted, they have drawn intensive national scrutiny and study. This Policy Brief focuses on the nature and effectiveness of these plans. We first provide generic descriptions of three types of plans, followed by a synthesis of research results on their effectiveness. A set of guidelines for effective practice is then provided to help states and districts embarking on these forms of performance pay. We conclude with a look ahead at recent developments in performance pay plans and other deviations from the traditional teacher salary schedule. Disciplines Education Economics | Teacher Education and Professional Development Comments View on the CPRE website. This policy brief is available at ScholarlyCommons: http://repository.upenn. edu/cpre_policybriefs/38
Evolutionarily Conserved Interaction between the Phosphoproteins and X Proteins of Bornaviruses from Different Vertebrate Species

Bornavirus, a non-segmented, negative-strand RNA viruses, is currently classified into several genetically distinct genotypes, such as Borna disease virus (BDV) and avian bornaviruses (ABVs). Recent studies revealed that bornavirus genotypes show unique sequence variability in the putative 5′ untranslated region (5′ UTR) of X/P mRNA, a bicistronic mRNA for the X protein and phosphoprotein (P). In this study, to understand the evolutionary relationship among the bornavirus genotypes, we investigated the functional interaction between the X and P proteins of four bornavirus genotypes, BDV, ABV genotype 4 and 5 and reptile bornavirus (RBV), the putative 5′ UTRs of which exhibit variation in the length. Immunofluorescence and immunoprecipitation analyses using mammalian and avian cell lines revealed that the X proteins of bornaviruses conserve the ability to facilitate the export of P from the nucleus to the cytoplasm via interaction with P. Furthermore, we showed that inter-genotypic interactions may occur between X and P among the genotypes, except for X of RBV. In addition, a BDV minireplicon assay demonstrated that the X and P proteins of ABVs, but not RBV, can affect the polymerase activity of BDV. This study demonstrates that bornaviruses may have conserved the fundamental function of a regulatory protein during their evolution, whereas RBV has evolved distinctly from the other bornavirus genotypes.
Data Provenance at Internet Scale: Architecture, Experiences, and the Road Ahead

Provenance is a way to answer “why” questions about computations. It has found a number of uses in the database community, such as debugging query answers or tracing unexpected results to database tuples. In fact, the ability to ask “why” can be useful for a much broader range of applications. In this paper, we summarize our experiences over the past few years in adapting provenance for diagnostic and forensic uses in networks and distributed systems. Our work draws inspirations from database provenance, yet the deployment scale, use cases, and distributed nature of networks require a signiﬁcant re-design of traditional data provenance models. We review a number of use cases, ranging from investigating intrusions to diagnosing (and even automatically ﬁxing) software-deﬁned networks, and present a uniﬁed system architecture that we have designed and implemented for provenance in distributed systems. We conclude with a discussion of open issues in this space.
Fault-based Testing of E-Commerce Applications

Because of their complexity, business transactions are prone to failure in many ways. This paper reports on our experience using a fault-based testing approach. The approach overcomes the limitations of specification-based approaches that derive from the intrinsic incompleteness of the specification, and from the focus of specifications on correct behaviors, rather than potential faults, and hence provides a complementary technique during the testing phase.
Optimal Constrained Stationary Intervention in Gene Regulatory Networks

A key objective of gene network modeling is to develop intervention strategies to alter regulatory dynamics in such a way as to reduce the likelihood of undesirable phenotypes. Optimal stationary intervention policies have been developed for gene regulation in the framework of probabilistic Boolean networks in a number of settings. To mitigate the possibility of detrimental side effects, for instance, in the treatment of cancer, it may be desirable to limit the expected number of treatments beneath some bound. This paper formulates a general constraint approach for optimal therapeutic intervention by suitably adapting the reward function and then applies this formulation to bound the expected number of treatments. A mutated mammalian cell cycle is considered as a case study.
An objective 3D quality assessment model to adjust stereo camera baseline

Stereoscopic video systems aim to confer a true three-dimensional (3D) view of the real world. However, in the process of 3D image acquisition and display, eventual distortions may affect the 3D perceptual quality, leading to visual discomfort. As visual comfort is a key issue when dealing with 3D acceptance, subjective tests (that are time consuming and cannot provide quality scores on the fly) have been conducted in order to establish 3D assessment factors. In this work, we use the ground truth of a publicly available database in order to develop a method to automatically assess the visual comfort of stereoscopic imagery. The assessment has the objective of assisting in the adjustment of stereo camera baselines. The method employs stereo vision geometry and stereo matching algorithms to estimate depth planes, for each video frame, in order to associate their locations with different visual comfort zones. The proposed method shows a high level of correlation with subjective tests, comparing favorably with another proposal from the literature.
Left ventricular mass regression after sutureless implantation of the Perceval S aortic valve bioprosthesis: preliminary results.

OBJECTIVES Left ventricular (LV) hypertrophy in aortic stenosis (AS) is considered a compensatory response helping maintain systolic function, but constitutes a risk factor for cardiac morbidity and mortality. The aim of this study was to assess the degree of LV mass regression after sutureless implantation of the Perceval S aortic valve bioprosthesis (Sorin Group, Saluggia, Italy). METHODS Between March 2010 and July 2012, 78 patients with symptomatic AS underwent isolated aortic valve replacement (AVR) with the Perceval bioprosthesis. Mean age was 77.1 ± 5.3 years, 46 patients were female (59%) and mean logistic EuroSCORE was 11 ± 7.5%. Echocardiography was performed preoperatively, at discharge, and at follow-up (mean 13.5 ± 7.3 months). LV mass was calculated using the Devereux formula and indexed to body surface area. RESULTS There was 1 in-hospital non-cardiac death and 3 late deaths. LV mass index decreased from 148.4 ± 46 g/m(2) at baseline to 119.7 ± 38.5 g/m(2) at follow-up (P = 0.002). No significant changes were observed in LV hypertrophy and/or relative wall thickness >0.42 as well as in LV ejection fraction. Mean aortic gradient decreased from 49.5 ± 15.8 mmHg at baseline to 11.6 ± 5.1 mmHg at discharge and 8.3 ± 4.4 mmHg at follow-up (P < 0.001), resulting in significant clinical improvement. No moderate or severe paravalvular leakage was observed at discharge and at follow-up. CONCLUSIONS In AS patients, isolated AVR with the Perceval sutureless bioprosthesis is associated with significant LV mass regression at 1-year follow-up. However, longer-term follow-up is necessary to confirm these findings.
Effect of Fluoxetine Consumption on Orthodontic Tooth Movement in Rats

Objectives: Fluoxetine is a selective serotonin re-uptake inhibitor (SSRI) widely used for depression, bipolar disorder, anxiety and obsessive-compulsive disorder. The aim of this study was to assess the effect of fluoxetine on orthodontic tooth movement (OTM) in rats. Materials and Methods: Forty-five male Wistar rats were randomly divided into three groups namely the control group (no medication), saline and fluoxetine dissolved in saline. In all groups, nickel titanium closed-coil spring was used between the left maxillary central incisor and first molar to exert 60g force at 2mm activation. Radiographs were taken at one and 21 days. After 21 days, the rats were sacrificed. The distance between the first and second molar teeth, optical density of bone, periodontal ligament (PDL) width, lacuna length and depth and number of osteoclasts were measured and compared among the groups. Results: Tooth movement significantly increased in the fluoxetine group (P=0.005). No significant differences were found in osteoclast count (P=0.069). The PDL width in the mesioapical region of root was significantly different among the groups (P=0.015). Statistical analysis did not show significant differences in depth or length of lacunae in any examined part of the root (P>0.05). Bone densitometry results showed that in fluoxetine group, density of bone in all four areas (alveolar bone, hard palate, skull and mandibular bone) significantly decreased from day one to day 21 (P< 0.05). Conclusion: This study indicated that fluoxetine decreased bone density, which resulted in subsequently greater tooth movement in rats; however, further studies are needed on humans.
Colloidal suspensions, Brownian motion, molecular reality: a short history

In the first decade of the 20th century, nearly a hundred years of work on the phenomenon of Brownian motion culminated in theory and experiments that demonstrated irrefutably the discontinuous or molecular nature of matter. Colloidal suspensions and the phenomenon of Brownian motion thus became the key to confirmation of the 'new world-view' of statistical mechanics, the statistical basis of thermodynamics. One may conveniently identify four 'stages' in the historical development of 'Brownian motion science', characterized in turn by discovery, observation, theoretical prediction, and quantitative confirmation. We are living, of course, in the fifth stage, that of application: the modern discipline of 'soft matter'.
Formant compensation for auditory feedback with English vowels.

Past studies have shown that speakers spontaneously adjust their speech acoustics in response to their auditory feedback perturbed in real time. In the case of formant perturbation, the majority of studies have examined speaker's compensatory production using the English vowel /ɛ/ as in the word "head. " Consistent behavioral observations have been reported, and there is lively discussion as to how the production system integrates auditory versus somatosensory feedback to control vowel production. However, different vowels have different oral sensation and proprioceptive information due to differences in the degree of lingual contact or jaw openness. This may in turn influence the ways in which speakers compensate for auditory feedback. The aim of the current study was to examine speakers' compensatory behavior with six English monophthongs. Specifically, the current study tested to see if "closed vowels" would show less compensatory production than "open vowels" because closed vowels' strong lingual sensation may richly specify production via somatosensory feedback. Results showed that, indeed, speakers exhibited less compensatory production with the closed vowels. Thus sensorimotor control of vowels is not fixed across all vowels; instead it exerts different influences across different vowels.
The Effects of Warming and Nitrogen Addition on Soil Nitrogen Cycling in a Temperate Grassland, Northeastern China

Background Both climate warming and atmospheric nitrogen (N) deposition are predicted to affect soil N cycling in terrestrial biomes over the next century. However, the interactive effects of warming and N deposition on soil N mineralization in temperate grasslands are poorly understood. Methodology/Principal Findings A field manipulation experiment was conducted to examine the effects of warming and N addition on soil N cycling in a temperate grassland of northeastern China from 2007 to 2009. Soil samples were incubated at a constant temperature and moisture, from samples collected in the field. The results showed that both warming and N addition significantly stimulated soil net N mineralization rate and net nitrification rate. Combined warming and N addition caused an interactive effect on N mineralization, which could be explained by the relative shift of soil microbial community structure because of fungal biomass increase and strong plant uptake of added N due to warming. Irrespective of strong intra- and inter-annual variations in soil N mineralization, the responses of N mineralization to warming and N addition did not change during the three growing seasons, suggesting independence of warming and N responses of N mineralization from precipitation variations in the temperate grassland. Conclusions/Significance Interactions between climate warming and N deposition on soil N cycling were significant. These findings will improve our understanding on the response of soil N cycling to the simultaneous climate change drivers in temperate grassland ecosystem.
Notch signaling is an important regulator of type 2 immunity

Notch ligands and receptors have been implicated in helper T cell (Th cell) differentiation. Whether Notch signals are involved in differentiation of T helper type 1 (Th1) cells, Th2 cells, or both, however, remains unresolved. To clarify the role of Notch in Th cell differentiation, we generated mice that conditionally inactivate Notch signaling in mature T cells. Mice that lack Notch signaling in CD4+ T cells fail to develop a protective Th2 cell response against the gastrointestinal helminth Trichuris muris. In contrast, they exhibit effective Th1 cell responses and are able to control Leishmania major infection. These data demonstrate that Notch signaling is a regulator of type 2 immunity.