Miracle-dz/UniFAR-FTUs huggingface dataset:
Control

Psychiatric patient assaults on staff are a serious problem, affecting staff, patients, and organizations. To understand the etiology of aggressive events, researchers have documented characteristics of aggressive patients, their victims, and to a lesser degree, the patient–provider interaction. Missing in the literature is how staff’s different perceptions of aggressive incidents might impact their reactions. In this study, we conducted in-depth, semistructured interviews with 11 health care professionals working in a psychiatric ward in one Israeli psychiatric hospital. Through content analysis, we revealed two main themes: patients’ and providers’ controllability over patients’ aggression. From the intersection of these two themes, four prototypes of the aggressive encounter emerged: the power struggle, the therapeutic encounter, inverse power relations, and victim-to-victim encounters, each distinctively characterized by different emotional, cognitive, and behavioral responses. We discuss our findings in light of attribution theory, which carries important theoretical and practical implications for handling aggression.
Low incidence of reinfection with the hepatitis C virus following treatment in active drug users in Amsterdam

Background More than two-thirds of hepatitis C virus (HCV) infections are associated with injecting drug use. Despite the wide availability of standard treatment with pegylated interferon and ribavirin, active drug users (DU) have limited access to HCV treatment. Physicians may be reluctant to prescribe treatment because of the presumed high risk of reinfection. However, data on reinfection in treated DU remain scarce. Methods Active DU with chronic HCV infection were treated in a multidisciplinary setting. After achieving a sustained virologic response, patients were tested at 6–12-monthly intervals for HCV RNA. To distinguish between relapse and reinfection, sequence and phylogenetic analyses were performed on the NS5B region of the HCV genome. The incidence of reinfection was calculated using person–time techniques. Results From April 2005 to March 2010, 69 active DU treated for HCV had sufficient follow-up, median 2.5 years (interquartile range, 1.6–3.7). Sustained virologic response was achieved in 42 patients (61%). During follow-up, 41 patients remained HCV RNA-negative; of these, two patients died. During treatment, five out of 41 injected drugs, which increased to 11 out of 41 after the end of treatment. One case of reinfection was observed, followed by spontaneous clearance of the virus. The overall incidence was 0.76/100 person-years (95% confidence interval 0.04–3.73). For only those individuals reporting injecting drug use, the incidence was 3.42/100 person-years (95% confidence interval 0.17–16.90). Conclusion We report a low incidence of HCV reinfection following treatment in DU participating in a multidisciplinary programme. Active drug use, including injecting, should not preclude access to treatment for HCV.
2-DE proteomics analysis of drought treated seedlings of Quercus ilex supports a root active strategy for metabolic adaptation in response to water shortage

Holm oak is a dominant tree in the western Mediterranean region. Despite being well adapted to dry hot climate, drought is the main cause of mortality post-transplanting in reforestation programs. An active response to drought is critical for tree establishment and survival. Applying a gel-based proteomic approach, dynamic changes in root proteins of drought treated Quercus ilex subsp. Ballota [Desf. ] Samp. seedlings were followed. Water stress was applied on 20 day-old holm oak plantlets by water limitation for a period of 10 and 20 days, each followed by 10 days of recovery. Stress was monitored by changes in water status, plant growth, and electrolyte leakage. Contrary to leaves, holm oak roots responded readily to water shortage at physiological level by growth inhibition, changes in water status and membrane stability. Root proteins were extracted using trichloroacetate/acetone/phenol protocol and separated by two-dimensional electrophoresis. Coomassie colloidal stained gel images were analyzed and spot intensity data subjected to multivariate statistical analysis. Selected consistent spots in three biological replicas, presenting significant changes under stress, were subjected to MALDI-TOF mass spectrometry (peptide mass fingerprinting and MS/MS). For protein identification, combined search was performed with MASCOT search engine over NCBInr Viridiplantae and Uniprot databases. Data are available via ProteomeXchange with identifier PXD002484. Identified proteins were classified into functional groups: metabolism, protein biosynthesis and proteolysis, defense against biotic stress, cellular protection against abiotic stress, intracellular transport. Several enzymes of the carbohydrate metabolism decreased in abundance in roots under drought stress while some related to ATP synthesis and secondary metabolism increased. Results point at active metabolic adjustment and mobilization of the defense system in roots to actively counteract drought stress.
Stylised facts of financial time series and hidden Markov models in continuous time

Hidden Markov models are often applied in quantitative finance to capture the stylised facts of financial returns. They are usually discrete-time models and the number of states rarely exceeds two because of the quadratic increase in the number of parameters with the number of states. This paper presents an extension to continuous time where it is possible to increase the number of states with a linear rather than quadratic growth in the number of parameters. The possibility of increasing the number of states leads to a better fit to both the distributional and temporal properties of daily returns.
Synthesis and Characterization of Conducting Composites of Polypyrrole/Polypyrrole-Coated Short Nylon Fiber and Natural Rubber

Pyrrole was polymerized in the presence of anhydrous ferric chloride as oxidant and p-toluene sulphonic acid as dopant. Polypyrrole-coated short Nylon fibers were prepared by polymerizing pyrrole in the presence of short Nylon fibers. The resultant polypyrrole (PPy) and polypyrrole-coated Nylon fiber (F-PPy) were characterized using SEM and then used to prepare rubber composites based on natural rubber. The cure pattern, cure kinetics, filler dispersion, DC conductivity, mechanical properties and morphology of the resulting composites were studied. The presence of PPy-coated fibers in the natural rubber/PPy system reduced the cure time significantly. The DC conductivity of the composites was found to be better for the F-PPy system compared to PPy-filled NR composite. The F-PPy system also showed better tensile strength, modulus and tear resistance.
A Dynamic Topic Model and Matrix Factorization-Based Travel Recommendation Method Exploiting Ubiquitous Data

The vast volumes of community-contributed geotagged photos (CCGPs) available on the Web can be utilized to make travel location recommendations. The sparsity of user location interactions makes it difficult to learn travel preferences, because a user usually visits only a limited number of travel locations. Static topic models can be used to solve the sparsity problem by considering user travel topics. However, all travel histories of a user are regarded as one document drawn from a set of static topics, ignoring the evolving of topics and travel preferences. In this paper, we propose a dynamic topic model (DTM) and matrix factorization (MF)-based travel recommendation method. A DTM is used to obtain the temporally fine-grained topic distributions (i.e., implicit topic information) of users and locations. In addition, a large amount of explicit information is extracted from the metadata and visual contents of CCGPs, check-ins, and point of interest categories datasets. The information is used to obtain user–user and location–location similarity information, which is imposed as two regularization terms to constraint MF. The proposed method is evaluated on a publicly available Flickr dataset. Experimental results demonstrate that the proposed method can generate significantly superior recommendations compared to other state-of-the-art travel location recommendation studies.
Histopathological investigation of glioblastomas resected under bevacizumab treatment

To date, no clinical observations have been reported for histopathological changes in human gliomas under antiangiogenic treatment. We collected six glioblastomas resected under bevacizumab treatment. Histopathological investigation was performed by hematoxilyn-eosin staining and immunohistochemistry for CD34, VEGF, VEGFR1/2, HIF-1α, CA9, and nestin as compared to eleven control glioblastomas to assess the differences in histological features, microvessel density, expression of VEGF and its receptors, tumor oxygenation, and status of glioma stem-like cells. In the six tumors resected under bevacizumab, microvascular proliferation was absent, and microvessel density had significantly decreased compared with that of the controls. The expressions of VEGF and its receptors were downregulated in two cases of partial response. HIF-1α or CA9 expression was decreased in five of the six tumors, whereas the decreased expression of these markers was noted in only one of the 11 control glioblastomas. The expression of nestin significantly decreased in the six tumors compared with that of the controls, with the remaining nestin-positive cells being relatively concentrated around vessels. We provide the first clinicopathological evidence that antiangiogenic therapy induces the apparent normalization of vascular structure, decrease of microvessel density, and improvement of tumor oxygenation in glioblastomas. These in situ observations will help to optimize therapy.
Magnitude and Predisposing Factors of Difficult Airway during Induction of General Anaesthesia

Objective To assess magnitude and predisposing factors of difficult airway during induction of general anaesthesia. Methods Hospital based cross sectional study carried out to determine the incidence of difficult mask ventilation, difficult laryngoscopy (Cormack and Lehane III and IV), difficult intubation (IDS ≥ 5), and failed intubation. The association between each predisposing factor and airway parameters with components of difficult airway is investigated with binary logistic regression. Sensitivity, specificity, positive and negative predictive value of the test, and odds ratio with 95% confidence interval were calculated to determine the association between independent and dependent variable. Result The incidence of difficult laryngoscopy, difficult intubation, and failed intubation are 12.3%, 9%, and 0.005%, respectively. Mouth opening < 30 mm and Mallampati classes III and IV are the most sensitive tests and second high specific test next to combination of tests to predict difficult intubation and laryngoscopy (P value < 0.001). Unrestricted multiple attempt without alternative airway techniques resulted in exponential increase in desaturation episodes and further difficulty of airway management (P value < 0.001). Discussion and Conclusion Mallampati classes III and IV, mouth opening ≤ 30 mm, jaw slide grade C, attempt > 3, and ineffective alternative technique have increased predictability value of difficult airway.
Lenticular Rubidium Uptake and Plasma Renin Activity in Weanling Cataract‐Prone Salt‐Sensitive Rats

Our earlier studies of cataracts in Dahl salt-sensitive (DS) rats suggested the possibility of altered lens ion transport as a contributing factor in cataractogenesis in this genetic model. We also observed that those weanling DS rats with the greatest pressor response to a high salt diet eventually developed cataracts, and that changes in salt intake modified cataract formation. In the present studies, we measured lens wRb uptake as an index of sodium-potassium adenosine triphosphatase [(Na+,K+)-ATPase] activity in weanling DS rats before the development of cataracts or sustained hypertension. Additionally, plasma renin activity was measured to indirectly assess our hypothesis that the difference between cataract-prone DS rats and DS rats unlikely to develop cataracts might be a difference in degree of salt sensitivity. At the age of 4 weeks, 50 DS and 25 salt-resistant (DR) rats were given a high sodium diet for 2 weeks, at which time the rats were divided into three groups based on the systolic blood pressure response, that is, cataract-prone DS rats with systolic blood pressure equal to or greater than 155 mm Hg, DS rats unlikely to develop cataracts with systolic blood pressure less than or equal to 125 mm Hg, and DR rats. Lens and aqueous humor Na+ and K+, lens dry weight, and water content were not significantly different among the three groups of weanling rats. Plasma renin activity was lowest in cataract-prone DS rats and low in DS rats unlikely to develop cataracts when compared with values in DR rats. Lens ouabain-sensitive wRb uptake was increased in cataract-prone DS rats but not in DS rats unlikely to develop cataracts as compared with values in DR rats. Ouabain-insensitive MRb uptake was not significantly different among the three groups. The positive correlation between systolic blood pressure and lens ouabain-sensitive MRb uptake in weanling cataract-prone DS rats, and the fact that the lowest plasma renin activity was in this group suggest that salt sensitivity might be greatest among rats that eventually develop cataracts. These data also show altered lens ion transport before cataracts or sustained hypertension in cataract-prone DS rats, and raise the possibility of a generalized disturbance in passive or active ion transport as an initiating defect in cataracts associated with salt-sensitive hypertension.
Embryology of the Pancreatic Duct System

Background/Aims: It has been suggested that the distal portion of the dorsal pancreatic duct and the ventral pancreatic duct usually merge into the main pancreatic duct, and the proximal portion of the dorsal pancreatic duct becomes the accessory pancreatic duct. In this study, we investigated the embryology of the accessory pancreatic duct roentgenographically and immunohistochemically. Methods/Results: The accessory pancreatic duct shows two different patterns in pancreatograms: the long and the short type. The accessory pancreatic duct of the long type forms a straight line and joins the main pancreatic duct at the neck portion of the pancreas. The accessory pancreatic duct of the short type joins the main pancreatic duct near its first inferior branch. Long inferior branches from the accessory pancreatic duct were found in 74.6% with the long type, significantly more often than in the short type (29.3%). Patency of the long type was (74.5%) significantly greater than in the short type (36.2%). Immunohistochemically, we found the main pancreatic duct between the junction with the accessory pancreatic duct and the neck portion of the autopsy pancreas in the short type was located within the ventral pancreas, characterized by pancreatic polypeptide-rich islets. Conclusion: The long type represents a continuation of the main duct of the dorsal primordium. The short type is very likely formed by the proximal main duct of the dorsal primordium and its long inferior branch, with the main duct of the dorsal primordium at the point of connection with the main duct of the ventral primordium being obliterated and replaced by this additional communication.
Validity and Reliability of a Work History Questionnaire Derived From the Job Content Questionnaire

Job design risk factors for hypertension and heart disease have often been assessed by the Job Content Questionnaire (JCQ). Job characteristics are typically assessed only once, however, which can result in misclassification and bias results toward the null. Newer approaches, which assess job characteristics over a working life, are hampered by the need to ask numerous questions about each job, increasing survey length and potentially reducing response rates. Participants in the Work Site Blood Pressure Study, a prospective study of psychosocial factors and ambulatory blood pressure, completed the JCQ about their current jobs. At later dates, 213 employed men, a subset of the original cohort, retrospectively completed the Work History Questionnaire (WHQ), a short version of the JCQ, for each past job. The WHQ exhibited moderate validity for assessing past job characteristics, a weak association with systolic blood pressure, and expected patterns of change over time. Thus, it may be a valuable tool for measuring the health effects of historical job characteristics, which often change over time.
Transient structure and dynamics in the disordered c-Myc transactivation domain affect Bin1 binding

The crucial role of Myc as an oncoprotein and as a key regulator of cell growth makes it essential to understand the molecular basis of Myc function. The N-terminal region of c-Myc coordinates a wealth of protein interactions involved in transformation, differentiation and apoptosis. We have characterized in detail the intrinsically disordered properties of Myc-1–88, where hierarchical phosphorylation of S62 and T58 regulates activation and destruction of the Myc protein. By nuclear magnetic resonance (NMR) chemical shift analysis, relaxation measurements and NOE analysis, we show that although Myc occupies a very heterogeneous conformational space, we find transiently structured regions in residues 22–33 and in the Myc homology box I (MBI; residues 45–65); both these regions are conserved in other members of the Myc family. Binding of Bin1 to Myc-1–88 as assayed by NMR and surface plasmon resonance (SPR) revealed primary binding to the S62 region in a dynamically disordered and multivalent complex, accompanied by population shifts leading to altered intramolecular conformational dynamics. These findings expand the increasingly recognized concept of intrinsically disordered regions mediating transient interactions to Myc, a key transcriptional regulator of major medical importance, and have important implications for further understanding its multifaceted role in gene regulation.
Injective Modules and Prime Ideals of Universal Enveloping Algebras

In this paper we study injective modules over universal enveloping algebras of finite-dimensional Lie algebras over fields of arbitrary characteristic. Most of our results are dealing with fields of prime characteristic but we also elaborate on some of their analogues for solvable Lie algebras over fields of characteristic zero. It turns out that analogous results in both cases are often quite similar and resemble those familiar from commutative ring theory.
An OSPF-Integrated Routing Strategy for QoS-Aware Energy Saving in IP Backbone Networks

This paper deals with an energy saving routing solution, called Energy Saving IP Routing (ESIR), to be applied in an IP network. ESIR operation is integrated with Open Shorthest Path First (OSPF) protocol and allows the selection of the links to be switched off so that the negative effects of the IP topology reconfiguration procedures are avoided. The basic mechanisms which ESIR is based on are the concepts of SPT exportation and move. These mechanisms allow to share a Shortest Path Tree (SPT) between neighbor routers, so that the overall set of active network links can be reduced. Properties of moves are defined and the energy saving problem in an IP network is formulated as the problem of finding the Maximum Set of Compatible Moves (MSCM). The MSCM problem is investigated in two steps: firstly, a relaxed version of the problem, named basic MSCM problem, is considered in which QoS requirements are neglected; in the second step, the solution of the full problem, named QoS-aware MSCM problem, is faced. We prove that the basic MSCM problem can be formulated as the well-known Maximum Clique Problem in a graph; instead the QoS-aware MSCM introduces a condition equivalent to the Knapsack problem. ILP formulations to solve both the problems are given and heuristics to solve them in practical cases are proposed. The performance evaluation shows that in a real ISP network scenario ESIR is able to switch off up to 30% of network links by exploiting over-provisioning adopted by operators in the network resource planning phase and typical daily traffic trend.
Intelligent Testing can be Very Lazy

Testing is a search process and a test suite is complete when the search has examined all the comers of the program. Standard models of test suite sizes are gross over-estimates since they are unaware of the nature of that search space. For example, only a small part of the possible search space is ever exercised in practice. Further, a repeated result is that a few random searches often yields as much information as more thorough search strategies. Hence, only a few tests are needed to sample the range of behaviours of a program.
Development of a micromirror based laser vector scanning automotive HUD

A micromirror based laser vector scanning Head-up Display (HUD) system for automotive applications is presented. A 2D non-resonant micromiorror is used for fast steering of a laser beam to generate patterns showing the speed information, which could be either displayed as a virtual image in front of the vehicle or projected on the windshield. An open-loop control algorithm is developed to control the micromirror. A prototype of the HUD system is developed and tested.
Anaerobic Corrosion of Reinforcement

Anaerobic corrosion of steel reinforcement is rarely reported and limited literature is available on the subject. Corrosion of steel is an electrochemical process requiring a supply of oxygen in the presence of moisture. Steel corrosion product usually occupies a much larger volume than the un-corroded steel resulting in cracked or spalled concrete. If the supply of oxygen is restricted, black rust may be formed by the process of anaerobic corrosion. Black rust is not expansive, which makes it particularly difficult to detect in reinforced concrete. This paper presents a case study of anaerobic corrosion in the Mizen Bridge, together with an in-depth review of anaerobic corrosion of reinforcement in concrete, outlining black rust formation, characteristics and detection methods.
Incorporating Metadata into Dynamic Topic Analysis

Everyday millions of blogs and micro-blogs are posted on the Internet These posts usually come with useful metadata, such as tags, authors, locations, etc. Much of these data are highly specific or personalized. Tracking the evolution of these data helps us to discover trending topics and users' interests, which are key factors in recommendation and advertisement placement systems. In this paper, we use topic models to analyze topic evolution in social media corpora with the help of metadata. Specifically, we propose a flexible dynamic topic model which can easily incorporate various type of metadata. Since our model adds negligible computation cost on the top of Latent Dirichlet Allocation, it can be implemented very efficiently. We test our model on both Twitter data and NIPS paper collection. The results show that our approach provides better performance in terms of held-out likelihood, yet still retains good interpretability.