Miracle-dz/UniFAR-FTUs huggingface dataset:
Hereditary Thrombophilic Risk Factors and Venous Thromboembolism in Istanbul, Turkey: The Role in Different Clinical Manifestations of Venous Thromboembolism

The aim of this study was to investigate the hereditary thrombophilic risk factors in patients with venous thromboembolism (VTE) and whether these risk factors play a different role in patients with isolated pulmonary embolism (PE) as compared with patients with deep vein thrombosis (DVT) and patients with PE + DVT. The protein C (PC), protein S, antithrombin activities, homocysteine levels, and factor V Leiden (FVL) G1691A and prothrombin G20210A mutations were evaluated in 191 patients with VTE and 191 controls. The prevalence of FVL and PC deficiency were higher in patients (P = .003 and P = .02, respectively). There was no significant difference for the other risk factors. The combination of thrombophilic risk factors was significantly higher in patients with DVT + PE as compared with patients with isolated PE or DVT (P = .04). In conclusion, the most important hereditary risk factors for VTE in this study were the FVL mutation and PC deficiency.
Results of laparoscopic pelvic and/or para-aortic lymphadenectomy in gynecologic oncology patients in Bangkok Metropolitan Administration Medical College and Vajira Hospital.

OBJECTIVE To determine the results of laparoscopic lymphadenectomy in gynecologic oncology patients. MATERIAL AND METHOD Medical records of 31 gynecologic oncology patients who underwent laparoscopic lymphadenectomy between November 1, 2004 and February 28, 2007 were retrospectively reviewed. RESULTS The median age of the study population was 47 years (range 24-77 years). Sixteen patients (51.6%) had endometrial cancer while 15 (48.4%) had ovarian malignancy, with median numbers of resected pelvic and paraaortic nodes of 12 (range 3-30 nodes) and 1 (range 1-3 nodes). The groups of lymphadenectomy only, lymphadenectomy with total laparoscopic hysterectomy, and lymphadenectomy with laparoscopic assisted vaginal hysterectomy had median blood losses of 100 ml (range 30-220 ml), 350 ml (range 100-800 ml), and 200 ml (range 150-400 ml) respectively. Accidental injuries of common iliac artery and large bowel occurred in two patients, all of whom were converted to a laparotomy for correcting the damaged sites. Overall, the median duration for postoperative recovery was three days (range 2-8 days). CONCLUSION The results suggest that surgical staging for gynecologic malignancies can be adequately performed through laparoscopic surgery, with benefit in terms of early postoperative recovery.
Photonic Crystal Ring Resonator based Bandpass Filter

In this paper, two dimensional Photonic Crystal square lattice circular ring resonator based Bandpass Filter (BPF) is designed by coupling in-line quasi waveguides and resonant cavity. The output efficiency of the circular ring resonator is investigated by varying size of the cavity. The normalized transmission spectra of circular Photonic Crystal Ring Resonator (PCRR) have been studied by using the Finite Difference Time Domain (FDTD) method. The Photonic Bandgap (PBG) has been calculated by Plane Wave Expansion (PWE) method. The simulation shows 100% transfer efficiency and 25 nm of bandwidth over the range of 1575 nm to 1600 nm. The impact of number of rings in the ring is also studied for determining the output efficiency and bandwidth.
Lack of feedback inhibition on rat basolateral amygdala following stress or withdrawal from sedative‐hypnotic drugs

Previous research has demonstrated that suppression of inhibition in projection neurons of the basolateral complex of the amygdala (BLA) represents an essential mechanism underlying the emergence of negative emotional responses, including exaggerated fear and anxiety. The present work evaluates inhibitory postsynaptic potentials (IPSPs) in pyramidal projection neurons of the BLA in rats subjected to either diazepam or ethanol withdrawal or uncontrollable stress. These are experimental paradigms conducive to a negative emotional state. In slices containing the BLA, IPSPs were studied using whole‐cell patch clamp. In control animals, a small IPSP was evoked by sub‐threshold stimulation of the external capsule. When an action potential (AP) was evoked by supra‐threshold stimuli, IPSPs were considerably larger; these IPSPs were sensitive to blockade of GABAA receptors by picrotoxin. However, IPSPs were clearly reduced in diazepam‐ or ethanol‐withdrawn and in stressed rats. Firing of an AP by a depolarizing pulse applied through the patch pipette consistently evoked an inhibitory postsynaptic current (IPSC) in the pyramidal neurons of control animals from all three experimental models; these IPSCs were mediated by GABAA receptor activation and were blocked after suppression of glutamatergic transmission. In contrast, no IPSCs were observed in slices from diazepam‐ or ethanol‐withdrawn or stressed animals, although the depolarizing pulse regularly evoked an AP in pyramidal neurons. It is concluded that, in withdrawn or stressed rats, GABAergic disinhibition occurs due to attenuation or suppression of feedback inhibition.
Media richness, social presence, group cohesion and content of computer-mediated and face-to-face communication

Even though investigations of knowledge construction within CMC have been conducted (e.g. Gunawardena, Lowe and Anderson, 1997; Schellens & Valcke, 2004), no research has compared F2F communication and CMC in terms of the ability to solve complex tasks and to develop group cohesion. Group cohesion has been found to be vital for group cooperation and performance. Eight self-formed groups of 5 student participants each volunteered to participate in this study. Each group was required to solve two standardised, complex tasks in the same order. Student groups were randomly assigned to one of four medium combinations with two groups per combination. The combinations were: F2F communication for both tasks, CMC for both tasks, F2F communication for the first task and CMC for the second task, and CMC for the first task and F2F communication for the second task. Measures of knowledge construction were taken using the IAM (Gunawardena et al., 1997), group cohesion (assessed before and after the tasks) using the GAS (Evans & Jarvis, 1986), and a self-developed scale to assess satisfaction with the process and the outcome. The results showed that CMC groups produced significantly fewer contributions, and took a longer time to complete tasks, but there was no significant difference between the two mediums in terms of knowledge construction. The medium combination of F2F communication followed by CMC, achieved the least time to completion; the second most effective medium for knowledge construction, the greatest satisfaction with respect to group processes and the decision in the first task, and achieved a significantly higher level of post-manipulation group cohesion.
The Use of Dreamwork with the Bonny Method of Guided Imagery and Music: A Survey of Current Practice

The purpose of this study was to examine current uses of dreamwork with the Bonny Method of Guided Imagery and Music (GIM) and to explore clinical examples of using dreams in GIM sessions. Respondents who valued their dreams were more likely to use dreamwork activities with GIM. Clinical and personal examples of using dreamwork with GIM were provided. The results provide a representation of how dreams are currently used with GIM and suggest the potential need for additional dreamwork training for GIM therapists.
Early Detection of At-Risk Students Using Machine Learning Based on LMS Log Data

Analytics in education has been received much attention over the past decade. It is necessary to maintain high retention rate in any institutions of higher education, therefore several attempts on the application of analytics have been done for this problem. To detect students at high drop-out risk early and intervene them effectively, utilizing the educational big data can be useful. In this paper, an automatic detection method of academically at-risk students by using log data of learning management systems is considered. Some well-known machine learning methods are used to build a predictive model of student performance evaluated by GPA. By using actual data set, we investigate an availability of the proposed method and discuss its ability to early detection of off-task behavior. The experimental results indicated that some characteristics of behavior about learning which affect the learning outcomes can be detected with only the online log data. Furthermore, comparative importance of explanatory variables obtained by the approach would help to estimate which variable affects comparatively to the learning outcome and it can be used in institutional research.
Class III &bgr;-Tubulin Is Constitutively Coexpressed With Glial Fibrillary Acidic Protein and Nestin in Midgestational Human Fetal Astrocytes: Implications for Phenotypic Identity

Class III &bgr;-tubulin isotype (&bgr;III-tubulin) is widely regarded as a neuronal marker in developmental neurobiology and stem cell research. To test the specificity of this marker protein, we determined its expression and distribution in primary cultures of glial fibrillary acidic protein (GFAP)-expressing astrocytes isolated from the cerebral hemispheres of 2 human fetuses at 18 to 20 weeks of gestation. Cells were maintained as monolayer cultures for 1 to 21 days without differentiation induction. By immunofluorescence microscopy, coexpression of &bgr;III-tubulin and GFAP was detected in cells at all time points but in spatially distinct patterns. The numbers of GFAP+ cells gradually decreased from Days 1 to 21 in vitro, whereas &bgr;III-tubulin immunoreactivity was present in 100% of cells at all time points. &bgr;-III-tubulin mRNA and protein expression were demonstrated in cultured cells by reverse-transcriptase-polymerase chain reaction and immunoblotting, respectively. Glial fibrillary acidic protein+/&bgr;-III-tubulin-positive cells coexpressed nestin and vimentin but lacked neurofilament proteins, CD133, and glutamate-aspartate transporter. Weak cytoplasmic staining was detected with antibodies against microtubule-associated protein 2 isoforms. Confocal microscopy, performed on autopsy brain samples of human fetuses at 16 to 20 gestational weeks, revealed widespread colocalization of GFAP and &bgr;III-tubulin in cells of the ventricular/subventricular zones and the cortical plate. Our results indicate that in the midgestational human brain, &bgr;III-tubulin is not neuron specific because it is constitutively expressed in GFAP+/nestin+ presumptive fetal astrocytes.
Undocumented Immigrant Threat and Support for Social Controls

Popular support for enhanced border and internal controls to deal with undocumented immigration is examined in relation to contextual measures of group threat as well as perceived levels of cultural and economic threat posed by undocumented immigrants. Results from a national survey of non-Latino respondents (N = 1,364) indicate that presumed threatening context measured in static terms is inconsequential. But when context is measured in dynamic terms that also reflect dispersion and potential contact, it significantly predicts support for border controls. Perceived threats are stronger predictors of support for enhanced controls than either contextual indicators of presumed threat or individual characteristics of respondents. Results also show that perceived economic and cultural threats mediate the effects of individual respondent characteristics and dynamic contextual conditions as well. Implications for future research on immigrant threat emphasize the importance of context measured in both change and dispersion-related terms and responses to threat that distinguish alternative dimensions of control. Future work should also consider that perceptions of threat may not only have direct influence on immigration policy preferences but can mediate the effects of context and individual characteristics on those preferences.
Risk management in the retail electricity market: the retailer's perspective

The retail company on the liberalized electricity market faces an increasing price risk exposure, stemming from the uncertain demand and the wholesale market price volatility. In the paper the influence of the stochastic parameters on the retailer's overall risk exposure is analyzed. After constructing the appropriate models for consumer demand, electricity spot price and forward price curve, the influence of the wholesale forward-price volatility in combination with the maturity of the sales-contract offer on the retailer's risk exposure is investigated. The proposed model was used for risk-premium determination, and the results were compared with those of a traditional technique from option-pricing theory. The results of a Monte Carlo simulation illustrate how forward-price volatility influences the retailer's total risk. The model is of immediate practical value to the electricity retailer since it enables the evaluation of risk arising from the different stochastic drivers.
Development and Characterization of Diamondback Moth Resistance to Transgenic Broccoli Expressing High Levels of Cry1C

ABSTRACT A field-collected colony of the diamondback moth, Plutella xylostella, had 31-fold resistance to Cry1C protoxin ofBacillus thuringiensis. After 24 generations of selection with Cry1C protoxin and transgenic broccoli expressing a Cry1C protein, the resistance that developed was high enough that neonates of the resistant strain could complete their entire life cycle on transgenic broccoli expressing high levels of Cry1C. After 26 generations of selection, the resistance ratios of this strain to Cry1C protoxin were 12,400- and 63,100-fold, respectively, for the neonates and second instars by a leaf dip assay. The resistance remained stable until generation 38 (G38) under continuous selection but decreased to 235-fold at G38 when selection ceased at G28. The Cry1C resistance in this strain was seen to be inherited as an autosomal and incompletely recessive factor or factors when evaluated using a leaf dip assay and recessive when evaluated using Cry1C transgenic broccoli. Saturable binding of 125I-Cry1C was found with brush border membrane vesicles (BBMV) from both susceptible and Cry1C-resistant strains. Significant differences in Cry1C binding to BBMV from the two strains were detected. BBMV from the resistant strain had about sevenfold-lower affinity for Cry1C and threefold-higher binding site concentration than BBMV from the susceptible strain. The overall Cry1C binding affinity was just 2.5-fold higher for BBMV from the susceptible strain than it was for BBMV from the resistant strain. These results suggest that reduced binding is not the major mechanism of resistance to Cry1C.
Evaluation of Pronunciation Variants in the ASR Lexicon for Different Speaking Styles

One of the challenges in automatic speech recognition is how to handle pronunciation variation. The main causes for pronunciation variation are the speaker (voice characteristics, accent, non-nativeness etc.) and the speaking style (reading, spontaneous responses, conversation etc.). An ASR system has basically two options for modelling the variation on the word and sub-word level: lexical modelling of the pronunciation variation or adaptation, i.e. re-training of the acoustic models. The answer to the question of which technique to choose, or how to combine them, may depend on the speaking style. We have therefore investigated the effects of using pronunciation variants for recognition of read speech, spontaneous dictation, and non-native speech. The variants in the standard purpose lexicon tested gave modest improvements and best results for read speech, which is the speaking style of the acoustic model training set.
Clustering of fibrillin (FBN1) missense mutations in Marfan syndrome patients at cysteine residues in EGF‐like domains

The Marfan syndrome is an autosomal dominant heritable disorder of connective tissue with prominent involvement of the ocular, skeletal, and cardiovascular systems. The gene on chromosome 15 encoding fibrillin (FBN1), a 350‐kDa glycoprotein component of the extracellular microfibril, is the site of defect in most, if not all cases. Complementary DNA sequence reveals a gene composed largely of epidermal growth factor‐like repeats, each containing six predictably spaced cysteine residues. To date, two FBN1 gene missense mutations have been reported. Here we describe the identification of three new missense mutations in the FBN1 gene in patients with the Marfan syndrome. All of the 5 characterized missense mutations occur within the epidermal growth factor‐like repeats of the FBN1 gene. In addition, 4 of 5 involve the substitution of cysteine residues and 3 of 5 substitute the third cysteine in the epidermal growth factor‐like motif consensus sequence. These data suggest that defined residues within EGF‐like domains of FBN1 have particular significance and, when altered, play a pivotal role in expression of the Marfan phenotype. © 1992 Wiley‐Liss, Inc.
Anxiety and Interfering Thoughts Their Effect on Social Interaction

The shy person, when placed in certain social situations, displays symptoms similar to those observed in varying degrees among people who can be characterized as anxiety prone as well as those who have clinically definable anxiety syndromes. Shy people, like most anxiety-prone individuals, are not anxious all the time and do not even experience anxiety in all social situations. In familiar social situations involving nondemanding friends and family members, shy people are likely to seem at ease, participate easily in the group and even take social initiatives. However, when they find themselves with unfamiliar companions or in settings where they believe that their social behavior will be evaluated, shy people become inhibited and anxious. At these times the shy individual is likely to be preoccupied with thoughts of personal inadequacy and with the desire to withdraw from the social interaction (Jones & Russell, 1982). Because of the similarities between the responses of the anxious person and the individual who is shy, it seems likely that some of the findings from the literature on evaluational anxiety may be of value both in studying shyness and in understanding the meaning of the concept more completely. One of the generalizations that has emerged from research on evaluational anxiety, or as it is often known, test anxiety, is that it is not really a unitary concept. Single sentence definitions of anxiety often acknowledge its various aspects by referring to the individual's apprehension, experience of an unpleasant emotional state, and physiological reactivity. More important than acknowledging this variety of characteristics, however, is the realization that they may not be very highly intercorrelated and consequently, thinking of anxiety as a unitary concept could be misleading to a significant degree. A more complex but preferable approach might be to focus on the components of anxiety and the correlations that might or might not exist among them (Lang, 1969, 1979; Rachman, 1978). At any given
Is Similarity in Leadership Related to Organizational Outcomes? The Case of Transformational Leadership

In this study, 213 supervisors from two public administration offices rated their own leadership behavior as well as their leaders' behavior on the MLQ. The relationship between own self-rated transformational leadership and perceived transformational leadership of the direct superior was examined. Furthermore, the relationship between perceived similarity between subordinate and supervisor in transformational leadership and leadership specific outcomes (extra effort, efficiency, and satisfaction with the leader), as well as organizational outcomes (commitment, overall satisfaction, organizational citizenship behavior, achievement orientation, stress, and irritability) was analyzed. Separating the participants into four groups with regard to their type of similarity/dissimilarity (similar low transformational leadership / similar high transformational leadership / dissimilar high transformational leadership of leader / dissimilar low transformational leadership of leader) led to differential correlations with the outcomes. Whereas a pattern close to the expected pattern was found for leader specific outcomes, very different patterns emerged for organizational outcomes including commitment, overall satisfaction, organizational citizenship behavior, stress, and absenteeism.
Productive aging in the workplace: Understanding factors that promote or impede psychological engagement in work

The productive aging paradigm emphasizes the importance of continued engagement in productive roles for maintaining health and vitality in later life. The word “engagement” is frequently used within this literature to refer to physical engagement with a role—or one’s involvement in the categorical sense. However, psychological engagement—or one’s subjective experience of a role as positive, meaningful, invigorating, and inspiring—is less frequently discussed. While there is a well-developed body of knowledge on the antecedents and consequences of psychological engagement with paid work, little is known about the role of age or age-related factors in these relationships. This dissertation begins to fill this gap in the knowledge base by drawing upon important insights from the business management and industrial/organizational psychology literatures to understand factors that may contribute to and/or detract from older adults’ ability to psychologically engage in work roles and whether these relationships vary for older adults (age 50 or older, n = 543) compared to midlife (age 35 to 49, n = 653) or younger adults (under age 35, n = 664). Results of multi-level regression analyses suggest that personal resources (i.e., core self-evaluations) and job resources (i.e., task variety, autonomy, friendship, task identity, task significance, supervisor support, job security, inclusion in decision-making, opportunities for learning and development, and team culture of flexibility) were main predictors of engagement for older adults as well as midlife and younger adults. Interestingly, the strength and nature of several of the job resource-engagement relationships were dependent upon job demands and/or core self-evaluations for older adults; however, in general, this was not the case for younger or midlife adults. Age differences remained even after controlling for several factors that could account for age-based differences in predictors of engagement (e.g., tenure). These findings provide a fuller understanding of the conditions that promote or impede psychological engagement with work in later life and will help policymakers and practitioners to better recognize and advocate for work contexts that maximize well-being for older adults.
Variation and text structure : the Discussion section in economics research articles

This paper is an attempt to use genre analysis to explore the sources of variation in the structure of texts produced within academic communities. The move structure of the Discussion Sections of 43 recent articles in agricultural economics journals sponsored by national professional associations in the United States, Canada, the United Kingdom, Australia and India was analyzed. The frequency and distribution of moves and the degree of structural complexity of these texts was examined. It was noted that these texts showed distinct preferences for certain moves although there was some variation within the subdiscipline. One noticeable feature was that texts from the Indian journal were much less complex that the others. It is suggested that variation in academic text structure reflects economic, social and cultural pressures and constraints and that competitive publishing situations lead to the elaboration of texts.