Miracle-dz/UniFAR-FTUs huggingface dataset:
A Mature NK Profile at the Time of HIV Primary Infection Is Associated with an Early Response to cART

Natural killer (NK) cells are major effectors of the innate immune response. Despite an overall defect in their function associated with chronic human immunodeficiency virus (HIV) infection, their role in primary HIV infection is poorly understood. We investigated the modifications of the NK cell compartment in patients from the ANRS-147-Optiprim trial, a study designed to examine the benefits of intensive combination antiretroviral therapy (cART) in patients with acute or early primary HIV infection. Multiparametric flow cytometry combined with bioinformatics analyses identified the NK phenotypes in blood samples from 30 primary HIV-infected patients collected at inclusion and after 3 months of cART. NK phenotypes were revealed by co-expression of CD56/CD16/NKG2A/NKG2C and CD57, five markers known to delineate stages of NK maturation. Three groups of patients were formed according to their distributions of the 12 NK cell phenotypes identified. Their virological and immunological characteristics were compared along with the early outcome of cART. At inclusion, HIV-infected individuals could be grouped into those with predominantly immature/early differentiated NK cells and those with predominantly mature NK cells. Several virological and immunological markers were improved in patients with mature NK profiles, including lower HIV viral loads, lower immune activation markers on NK and dendritic cell (DC), lower levels of plasma IL-6 and IP-10, and a trend to normal DC counts. Whereas all patients showed a decrease of viremia higher than 3 log10 copies/ml after 3 months of treatment, patients with a mature NK profile at inclusion reached this threshold more rapidly than patients with an immature NK profile (70 vs. 38%). In conclusion, a better early response to cART is observed in patients whose NK profile is skewed to maturation at inclusion. Whether the mature NK cells contributed directly or indirectly to HIV control through a better immune environment under cART is unknown. The NK maturation status of primary infected patients should be considered as a relevant marker of an immune process contributing to the early outcome of cART that could help in the management of HIV-infected patients.
Current status of renin–aldosterone angiotensin system-targeting anti-hypertensive drugs as therapeutic options for Alzheimer's disease

Introduction: Hypertension is a modifiable risk factor for Alzheimer's disease (AD) and other dementias. Yet, despite this well-documented association, few of the current strategies to treat AD are directed at this possible target. The renin–aldosterone angiotensin system (RAAS) is a centrally active modifiable pathway that is involved in cerebral blood flow regulation. Currently, three classes of RAAS-targeting drugs are licensed for treatment of peripheral hypertension – angiotensin-converting enzyme inhibitors (ACE-Is), angiotensin II receptor blockers (ARBs) and direct renin inhibitors (DRIs). All of these are generally well tolerated and have been shown to offer varying degrees of protection on aspects of cognition and dementia, thus making them an attractive therapeutic option for AD. Areas covered: This review summarises existing evidence regarding the plausibility of using RAAS-targeting drugs as a strategy to treat AD and highlights unresolved aspects to such approaches, namely the potential impact of altering angiotensin II-mediated processes in the central nervous system. Expert opinion: Continued biochemical research of the RAAS pathway in combination with formal investigation of current RAAS-modifying drugs in randomised clinical trials is now necessary to determine their therapeutic value in AD.
This is like that: The use of earlier problems and the separation of similarity effects.

Novices attempting to solve a problem often are reminded of an earlier problem that illustrated a principle. Two experiments examined how these earlier problems are used and how this use is related to these remindings. Subjects studied four probability principles with related word problems. Test problems varied in their similarity to the study problems on story lines, objects, and correspondence of objects (variable roles). Experiment 1 tested whether remindings cue the principle or serve as the sources of detailed analogies. When the appropriate formula was provided with each test, the similarity of story lines had no effect, but object correspondences had a large effect. These results support an analogical account in which mapping is affected by the similarity of objects between study and test problems. Experiment 2 began to separate the aspects of similarity affecting the access and use of earlier problems by showing that, with confusable principles, similar story lines increased the access, but did not affect the use. The access appears to be sensitive to the relative similarity of examples because with distinctive principles, similar story lines had little effect. Discussion focuses on the further specification of the processes of noticing and analogical use of earlier problems.
Migration route and spawning area fidelity by North Sea plaice

Data from plaice, Pleuronectes platessa L. , tagged with electronic data storage tags, were used to test whether these fishes exhibited migration route and spawning area fidelity in successive spawning seasons. Depth and temperature data were recorded for each fish over 365–512 days in the central North Sea and this information was used to reconstruct movements based on tidal locations. We discovered highly directed seasonal migrations from the winter spawning area south of a major topographical feature, Dogger Bank Tail End, to summer feeding grounds 250 km to the north in deep, cold, thermally stratified water. Our results show synchronous timing of migration, repeated pre– and post–spawning migration routes and 100% spawning area fidelity, including two individuals that returned to within 20 km of their previous season's spawning location. This is the first study to provide a complete reconstruction of annual migrations by individual fishes, showing strong homing behaviour along consistent migration routes.
Comment on Crocker's "An Analysis of University Definitions of Sexual Harassment"

In her article "An Analysis of University Definitions of Sexual Harassment" (Signs 8, no. 4 [Summer 1983]: 696-707), Phyllis L. Crocker evaluates the definitions of sexual harassment used by academic, professional, and governmental bodies. Her analysis is astute, enlightening, and important. However, she makes no mention of sexual harassment of women professors by their men students. ' There is a general lack of awareness of this type of harassment not only in Crocker's work and the official definitions but also in other research on sexual harassment within
CGI-58 facilitates the mobilization of cytoplasmic triglyceride for lipoprotein secretion in hepatoma cellss⃞s⃞ The online version of this article (available at http://www.jlr.org) contains supplementary data in the form of 2 figures. Published, JLR Papers in Press, July 30, 2007.

Comparative Gene Identification-58 (CGI-58) is a member of the α/β-hydrolase family of proteins. Mutations in the human CGI-58 gene are associated with Chanarin-Dorfman syndrome, a rare autosomal recessive genetic disease in which excessive triglyceride (TG) accumulation occurs in multiple tissues. In this study, we investigated the role of CGI-58 in cellular lipid metabolism in several cell models and discovered a role for CGI-58 in promoting the packaging of cytoplasmic TG into secreted lipoprotein particles in hepatoma cells. Using both gain-of-function and loss-of-function approaches, we demonstrate that CGI-58 facilitates the depletion of cellular TG stores without altering cellular cholesterol or phospholipid accumulation. This depletion of cellular TG is attributable solely to augmented hydrolysis, whereas TG synthesis was not affected by CGI-58. Furthermore, CGI-58-mediated TG hydrolysis can be completely inhibited by the known lipase inhibitors diethylumbelliferyl phosphate and diethyl-p-nitrophenyl phosphate, but not by p-chloro-mercuribenzoate. Intriguingly, CGI-58-driven TG hydrolysis was coupled to increases in both fatty acid oxidation and secretion of TG. Collectively, this study reveals a role for CGI-58 in coupling lipolytic degradation of cytoplasmic TG to oxidation and packaging into TG-rich lipoproteins for secretion in hepatoma cells.
Multidrug- and Extensively Drug-Resistant Uropathogenic Escherichia coli Clinical Strains: Phylogenetic Groups Widely Associated with Integrons Maintain High Genetic Diversity

In recent years, an increase of uropathogenic Escherichia coli (UPEC) strains with Multidrug-resistant (MDR) and Extensively Drug-resistant (XDR) profiles that complicate therapy for urinary tract infections (UTIs) has been observed and has directly impacted costs and extended hospital stays. The aim of this study was to determine MDR- and XDR-UPEC clinical strains, their virulence genes, their phylogenetic groups and to ascertain their relationship with integrons and genetic diversity. From a collection of 500 UPEC strains, 103 were selected with MDR and XDR characteristics. MDR-UPEC strains were mainly associated with phylogenetic groups D (54.87%) and B2 (39.02%) with a high percentage (≥70%) of several fimbrial genes (ecpA, fimH, csgA, and papGII), an iron uptake gene (chuA), and a toxin gene (hlyA). In addition, a moderate frequency (40–70%) of other genes (iutD, tosA, and bcsA) was observed. XDR-UPEC strains were predominantly associated with phylogenetic groups B2 (47.61%) and D (42.85%), which grouped with ≥80 virulence genes, including ecpA, fimH, csgA, papGII, iutD, and chuA. A moderate frequency (40–70%) of the tosA and hlyA genes was observed. The class 1 and 2 integrons that were identified in the MDR- and XDR-UPEC strains were associated with phylogenetic groups D, B2, and A, while the XDR-UPEC strains that were associated with phylogenetic groups B2, D, and A showed an extended-spectrum beta-lactamase (ESBL) phenotype. The modifying enzymes (aadA1, aadB, aacC, ant1, dfrA1, dfrA17, and aadA4) that were identified in the variable region of class 1 and 2 integrons from the MDR strains showed resistance to gentamycin (56.25 and 66.66%, respectively) and trimethoprim-sulfamethoxazole (84.61 and 66.66%, respectively). The MDR- and XDR-UPEC strains were distributed into seven clusters and were closely related to phylogenic groups B2 and D. The diversity analysis by PFGE showed 42.68% of clones of MDR-UPEC and no clonal association in the XDR-UPEC strains. In conclusion, phylogenetic groups including virulence genes are widely associated with two integron classes (1 and 2) in MDR- and XDR-UPEC strains.
The TANH Transformation

This paper describes properties of the tanh function from the standpoint of its use in robust signal processing and statistical estimation. It has recently been shown that the construction of circuits that perform tanh is very natural in present integrated circuit technology. Therefore, this transform is likely to become widely used in circuits that perform computations on (noisy) input signals, as well as in statistical analyses.
Growth and biochemical markers of growth in children with snoring and obstructive sleep apnea.

OBJECTIVE The pathophysiological mechanisms of growth impairment frequently associated with the obstructive sleep apnea syndrome (OSAS) in children are poorly defined. The main objective of this study was to evaluate whether nighttime upper airway obstruction attributable to adenotonsillar hypertrophy and subsequent surgical treatment affect the circulating concentrations of insulin-like growth factor-I (IGF-I) and IGF-binding protein 3 (IGFBP-3) along with other growth parameters in children. PATIENTS AND METHODS We initially studied 70 children (mean age: 5.8 years; range: 2.4-10.5 years) admitted to a university hospital because of clinical symptoms of OSAS. Their sleep was monitored with a 6-channel computerized polygraph. Data on anthropometry and circulating concentrations of IGF-I and IGFBP-3 were generated and compared with corresponding characteristics in control children (N = 35). Thirty children with an obstructive apnea-hypopnea index (OAHI) of 1 or more were categorized as children with OSAS (mean OAHI: 5.4 [95% confidence interval for mean (CI): 3.8-6.9]), whereas 40 children with an OAHI of <1 were considered as primary snorers (PS) (mean OAHI 0.13 [95% CI: 0.05-0.21]). Nineteen children with OAHI >2 underwent adenotonsillectomy attributable to OSAS and were reassessed 6 months later together with 34 nonoperated children with OAHI <2. RESULTS There were no initial differences in relative height and weight for height between the 3 groups of children. No differences were observed in peripheral IGF-I concentrations, but both OSAS and PS children had reduced peripheral IGFBP-3 levels. The operated children with initial OSAS experienced a highly significant reduction in their OAHI from 7.1 (95% CI: 5.1-9.1) to 0.37 (95% CI: 0.2-0.95). Weight-for-height, body mass index, body fat mass, and fat-free mass increased during the follow-up in the operated children with OSAS, whereas only fat-free mass and relative height increased in the PS children. Both the IGF-I and the IGFBP-3 concentrations increased significantly in the operated children, whereas no significant changes were seen in the PS children. CONCLUSIONS These observations indicate that growth hormone secretion is impaired in children with OSAS and PS. Respiratory improvement after adenotonsillectomy in children with OSAS results in weight gain and restored growth hormone secretion.
Changes in vasoactive intestinal peptide in gingival crevicular fluid in response to periodontal treatment.

AIMS To evaluate the role of the anti-inflammatory neuropeptide vasoactive intestinal peptide (VIP) in periodontal health and disease and to determine the effects of periodontal treatment, resulting in a return to periodontal health, on the levels of VIP in gingival crevicular fluid (GCF). METHODS At baseline, 10 subjects with periodontitis (nine females, one male, mean age 43.0, SD 7.3) started a course of non-surgical periodontal treatment. Clinical indices were measured at one periodontitis and one clinically healthy site at an initial visit and at 8 weeks after the completion of treatment in each subject. A 30-s sample of GCF was collected from each test site using perio paper strips. The volume of GCF was measured and each sample subsequently analysed for VIP by radioimmunoassay. One healthy site was sampled from each member of a control group (10 females, mean age 29.9, SD 8.2 years) with clinically healthy gingiva and no periodontitis. RESULTS The clinical condition of all periodontitis sites improved as a result of periodontal treatment. The levels of VIP (pg/30 s sample) in periodontitis-affected sites fell significantly from 302.0 (SD 181.2) at the initial visit to 78.0 (54.4) after treatment, p = 0.007. The reduction in the concentration of VIP (pg/ micro L) in GCF from 524.3 (322.3) to 280.8 (280.2) was not statistically significant. The levels of VIP in clinically healthy sites fell from 115.5. 5 (74.3) to 77.8 (32.3), n.s. and the concentration changed little from 883.8 (652.1) to 628.7 (323.3), n.s. There were substantially smaller amounts of VIP (25.8, SD 12.8) pg in healthy sites sampled from control subjects. CONCLUSIONS VIP is present in GCF in greater quantities in periodontitis-affected than clinically healthy sites. In addition, the reduction in inflammation resulting from effective periodontal treatment is associated with a reduction in the levels of VIP in gingival crevicular fluid.
Through the Wire: Relations of Power and Relations of Violence

This article seeks to explore the question, most starkly posed by Giorgio Agamben, of whether sovereign power can be challenged. By deploying readings of Agamben and Foucault that complement and illuminate each other, we propose that although sovereign power remains globally predominant, it is best considered not as a form of power relation but as a relation of violence. By exploring sovereign power in this way, we argue, alongside Agamben, that challenges to it are available in two modes: first, a refusal to draw lines between forms of life; and, secondly, an assumption of bare life. The availability of these forms of challenge is illustrated by examining practices of lip sewing amongst refugees. In the end, the refusal to draw lines and the assumption of bare life seek to reinstate properly political power relations with their accompanying freedoms and potentialities.
Characterization of Mandibular Bones in Senile Osteoporotic Mice

At present, little is known about the age-related changes in jaw bones. The aim of this study was to characterize the mandibles of 6 month-old senile osteoporotic mice, SAMP6, and compare with those of age-matched controls, SAMR1. In comparison to SAMR1, SAMP6 showed thinner cortical bone, lower bone volume, and poorly organized collagen matrix. The collagen fibril diameter in SAMP6 was significantly smaller than that of SAMR1. In SAMP6 both collagen content and cross-links were lower than those of SAMR1, but the ratio of the major mature cross-link (pyridinoline) to its precursor reducible cross-link (dehydrodihydroxylysinonorleucine/its ketoamine) was higher in comparison to SAMR1. In addition, the extent of lysine hydroxylation of collagen was higher in SAMP6 than that of SAMR1. These results indicate that not only the quantity of collagen but also its quality are altered in SAMP6 and may result in the age-associated osteoporotic defects of mandibles.
Non-critical supergravity (d > 1) and holography

In this paper we investigate the supergravity equations of motion associated with non-critical (d > 1) type-II string theories that incorporate RR forms. Using a superpotential formalism we determine several classes of solutions. In particular we find analytic backgrounds with a structure of AdSp + 2 × Sd − p − 2 and numerical solutions that asymptote a linear dilaton with a topology of R1,d − 3 × R × S1. The SUGRA solutions we have found can serve as anti holographic descriptions of gauge theories in a large-N limit which is different than the one of the critical gauge/gravity duality. It is characterized by N → ∞ and gYM2N ~ 1. We have made the first steps in analyzing the corresponding gauge theory properties like Wilson loops and the glue-ball spectra.
CONTESTED AUTONOMY

Commitments to truth and to “transparency,” or public accountability, are two central normative aspects of professional journalism. This article considers ways in which both are challenged and complemented by popular communicators, particularly bloggers, in today's media environment. While all professions claim autonomy over articulation and enactment of their own norms, definitions of professional constructs are now open to reinterpretation, and oversight of professional behavior is increasingly shared.
Separating Quantitative and Analytic Dimensions in the Swedish Scholastic Aptitude Test (SweSAT)

The aim of the present study was to further investigate the properties of a “quantitative” factor previously identified in the “diagrams, tables and maps” subtest of SweSAT. The analyses were carried out with a structural equation modelling technique on the spring 1991 version of SweSAT with 19‐year‐old test takers and were replicated on four ensuing versions of the test (n = 14,431–19,597). The “quantitative” factor was successfully separated from the analytic, problem‐solving dimension with regard to the first test, whereas the results of replications were somewhat less clear‐cut.
Factors associated with criminal convictions for sexually inappropriate behaviour in men with learning disabilities

Care professionals were interviewed regarding the extent, nature and victims of inappropriate sexual behaviour of 46 males with learning disabilities, and an adapted and expanded form of a version of the Structured Anchored Clinical Judgement risk assessment protocol (SACJ-Min: Hanson and Thornton, 2000) was completed for each client. Comparisons of the 16 criminally convicted and 30 non-convicted men revealed few differences on factors associated with sexual recidivism. However, convicted men were more likely to have targeted children and males as victims and had perpetrated more serious sexual offences. Variables that differed significantly, or nearly so, between the two groups were entered as predictors in a logistic regression analysis. The analysis generated a powerful model, accounting for almost 50% of the variance. However, the only significant predictors of convicted status to emerge from this analysis were child victim and, less reliably, emotional loneliness. The results suggest that the decision to prosecute a man with learning disabilities who displays sexually inappropriate behaviour is based more on the identity of the victim than on the nature of the offence.
Effects of proficiency and age of language acquisition on working memory performance in bilinguals

This study examined language proficiency and age of language acquisition influences on working memory performance in bilinguals. Bilingual subjects were administered reading span task in parallel versions for their first and second language. In Experiment 1, language proficiency effect was tested by examination of low and highly proficient second language speakers. In Experiment 2, age of language acquisition was examined by comparing the performance of proficient second language speakers who acquired second language either early or later in their lives. Both proficiency and age of language acquisition were found to affect bilingual working memory performance, and the proficiency effect was observed even at very high levels of language competence. The results support the notion of working memory as a domain that is influenced both by a general pool of resources and certain domain specific factors.
The boundary of universal discrete quantum groups, exactness, and factoriality

We study the C -algebras and von Neumann algebras associated with the universal discrete quantum groups. They give rise to full prime factors and simple exact C -algebras. The main tool in our work is the study of an amenable boundary action, yielding the Akemann-Ostrand property. Finally, this boundary can be identified with the Martin or the Poisson boundary of a quantum random walk.