Miracle-dz/UniFAR-FTUs huggingface dataset:
Short-term and working memory in children with specific language impairment

Investigations of the cognitive processes underlying Specific Language Impairment (SLI) have implicated deficits in the storage and processing of phonological or verbal information. This thesis reports five studies that investigated the role of short-term and working memory in children with SLI. Study 1 demonstrated SLI deficits on measures of verbal working memory, and short-term memory for verbal but not visuospatial information. Study 2 provided evidence that children with SLI perform at age-level on visuospatial working memory measures. Study 3 demonstrated slower processing in the SLI group across domains, as well as verbal storage decrements, with the greatest deficits found for tasks tapping both of these. Study 4 found SLI deficits on measures of nonword repetition in common use, with greater impairments on the task that relied to a lesser extent on short-term memory. Study 5 established more accurate recall for multisyllabic nonwords than matched single syllable lists for all groups, although the SLI group showed different patterns of phoneme retention. It is suggested that the combination of deficits in generalized processing speed and verbal storage in SLI may be expected to have a drastic and detrimental impact on learning, and provides an account of the disorder that could encompass the range of impairments observed in SLI. The findings also suggest that factors additional to short-term memory contribute to poor nonword repetition in SLI.
Childhood Adversities Increase the Risk of Psychosis: A Meta-analysis of Patient-Control, Prospective- and Cross-sectional Cohort Studies

Evidence suggests that adverse experiences in childhood are associated with psychosis. To examine the association between childhood adversity and trauma (sexual abuse, physical abuse, emotional/psychological abuse, neglect, parental death, and bullying) and psychosis outcome, MEDLINE, EMBASE, PsychINFO, and Web of Science were searched from January 1980 through November 2011. We included prospective cohort studies, large-scale cross-sectional studies investigating the association between childhood adversity and psychotic symptoms or illness, case-control studies comparing the prevalence of adverse events between psychotic patients and controls using dichotomous or continuous measures, and case-control studies comparing the prevalence of psychotic symptoms between exposed and nonexposed subjects using dichotomous or continuous measures of adversity and psychosis. The analysis included 18 case-control studies (n = 2048 psychotic patients and 1856 nonpsychiatric controls), 10 prospective and quasi-prospective studies (n = 41 803) and 8 population-based cross-sectional studies (n = 35 546). There were significant associations between adversity and psychosis across all research designs, with an overall effect of OR = 2.78 (95% CI = 2.34–3.31). The integration of the case-control studies indicated that patients with psychosis were 2.72 times more likely to have been exposed to childhood adversity than controls (95% CI = 1.90–3.88). The association between childhood adversity and psychosis was also significant in population-based cross-sectional studies (OR = 2.99 [95% CI = 2.12–4.20]) as well as in prospective and quasi-prospective studies (OR = 2.75 [95% CI = 2.17–3.47]). The estimated population attributable risk was 33% (16%–47%). These findings indicate that childhood adversity is strongly associated with increased risk for psychosis.
UbiNet: an online resource for exploring the functional associations and regulatory networks of protein ubiquitylation

Protein ubiquitylation catalyzed by E3 ubiquitin ligases are crucial in the regulation of many cellular processes. Owing to the high throughput of mass spectrometry-based proteomics, a number of methods have been developed for the experimental determination of ubiquitylation sites, leading to a large collection of ubiquitylation data. However, there exist no resources for the exploration of E3-ligase-associated regulatory networks of for ubiquitylated proteins in humans. Therefore, the UbiNet database was developed to provide a full investigation of protein ubiquitylation networks by incorporating experimentally verified E3 ligases, ubiquitylated substrates and protein–protein interactions (PPIs). To date, UbiNet has accumulated 43 948 experimentally verified ubiquitylation sites from 14 692 ubiquitylated proteins of humans. Additionally, we have manually curated 499 E3 ligases as well as two E1 activating and 46 E2 conjugating enzymes. To delineate the regulatory networks among E3 ligases and ubiquitylated proteins, a total of 430 530 PPIs were integrated into UbiNet for the exploration of ubiquitylation networks with an interactive network viewer. A case study demonstrated that UbiNet was able to decipher a scheme for the ubiquitylation of tumor proteins p63 and p73 that is consistent with their functions. Although the essential role of Mdm2 in p53 regulation is well studied, UbiNet revealed that Mdm2 and additional E3 ligases might be implicated in the regulation of other tumor proteins by protein ubiquitylation. Moreover, UbiNet could identify potential substrates for a specific E3 ligase based on PPIs and substrate motifs. With limited knowledge about the mechanisms through which ubiquitylated proteins are regulated by E3 ligases, UbiNet offers users an effective means for conducting preliminary analyses of protein ubiquitylation. The UbiNet database is now freely accessible via http://csb.cse. yzu.edu. tw/UbiNet/. The content is regularly updated with the literature and newly released data. Database URL: http://csb.cse. yzu.edu. tw/UbiNet/.
Prevalence of Hyponatremia in Intensive Care Unit Patients With Brain Injury in Kashan Shahid-Beheshti Hospital in 2012

Background Hyponatremia is a common disorder in patients with brain injury. It can result in acute and chronic complications providing this electrolytic disorder is not diagnosed and treated in due time. Objectives The aim of this study was to evaluate the prevalence of hyponatremia in 95 brain injury patients hospitalized in the intensive care unit (ICU) in Kashan Shahid-Veheshti hospital. Patients and Methods This trans-sectional study was conducted on brain injury patients (brain traumas, brain hemorrhage, meningitis and brain tumors) during their six-month stay in the ICU in Kashan Shahid-Beheshti hospital. Data were analyzed after excluding cases of pseudohyponatremia. Results Ninety-five patients with brain injury (69.5% male and 30.5% female ( had a mean age of 42.85 ± 22.59 years, while the hyponatremic patients had a mean age of 48.37 ± 24.03 years. Prevalence and occurrence of hyponatremia were 31.6% and 9.29 ± 6.8 days, respectively. This study revealed no meaningful differences between age, sex, underlying disease and the prevalence of hyponatremia. Conclusions Our study showed an elevated frequency of hyponatremia in patients with brain injuries in ICU which demands the effective approaches for an accurate and timely diagnosis of this electrolyte disorder.
Blood groups: In Health and Diseases

1 Molecular and Cell Biology Research Center, Department of Immunology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. 2 Department of Molecular Medicine, School of Advanced Medical Technologies, Tehran University of Medical Science, Tehran, Iran. 3 Department of Immunology, School of Medicine, Hamadan University of Medical Science, Hamadan, Iran. 4 Cancer Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Cardiovascular Management in Pregnancy

1254 Chronic hypertension in pregnancy is defined by the American College of Obstetrics and Gynecology (ACOG) as blood pressure ≥140 mm Hg systolic and/or 90 mm Hg diastolic before pregnancy or, in recognition that many women seek medical care only once pregnant, before 20 weeks of gestation, use of antihypertensive medications before pregnancy, or persistence of hypertension for >12 weeks after delivery. Chronic hypertension needs to be distinguished from new-onset hypertensive complications of pregnancy such as preeclampsia (elevated blood pressure and proteinuria often accompanied by evidence of maternal organ injury and fetal compromise from placental dysfunction) and gestational hypertension (elevated blood pressure alone after 20 weeks of gestation and most commonly in the mid to late third trimester without evidence or history of hypertension before pregnancy; Table 1).
Prognostic Factors in Transitional Cell Carcinoma of the Upper Urinary Tract after Radical Nephroureterectomy

Purpose The aim of this study was to evaluate the prognostic factors for survival in patients treated surgically for transitional cell carcinoma of the upper urinary tract (UUT-TCC). Materials and Methods We retrospectively reviewed the medical records of 87 patients (64 men and 23 women, mean age of 62.2 years) with UUT-TCC who had undergone radical nephroureterectomy at our institution between June 1994 and June 2009. The median follow-up period was 32 months. The prognostic significance of various clinicopathological variables for recurrence-free and cancer-specific survival was analyzed by using univariate and multivariate analysis. Results Of the total 87 patients, 21 patients (24.1%) developed local recurrence or distant metastasis and 16 patients (18.4%) died of disease during the follow-up period. The 5-year recurrence-free and cancer-specific survival rates were 74.6% and 75.2%, respectively. In the univariate analysis, hydronephrosis, T stage, N stage, and lymphovascular invasion (LVI) were significant prognostic factors for recurrence-free and cancer-specific survival. In the multivariate analysis, T stage and LVI were independent prognostic factors for recurrence-free and cancer-specific survival. Conclusions The T stage and LVI are independent prognostic factors for recurrence-free and cancer-specific survival in patients with UUT-TCC treated by radical nephroureterectomy. These findings would be helpful for guiding decisions about adjuvant therapies and the surveillance interval.
Using language as related stimuli for concept generation

This paper examines the use of language, specifically verbs, as stimuli for concept generation. Because language has been shown to be important to the reasoning process in general as well as to specific reasoning processes that are central to the design process, we are investigating the relationship between language and conceptual design. The use of language to facilitate different stages of the design process has been investigated in the past. Our previous work, and the work of others, showed that ideas produced can be expressed through related hierarchical lexical relationships, so we investigated the use of verbs within these hierarchical relationships as stimuli for ideas. Participants were provided with four problems and related verb stimuli, and asked to develop concepts using the stimuli provided. The stimuli sets were generated by exploring verb hierarchies based on functional words from the problem statements. We found that participants were most successful when using lower level (more specific) verbs as stimuli, and often higher level general verbs were only used successfully in conjunction with lower level verbs. We also observed that intransitive verbs (verbs that cannot take a direct object) were less likely to be used successfully in the development of concepts. Overall, we found that the verb chosen as stimulus by the participant directly affects the success and the type of concept developed.
Environmental enrichment does not influence hypersynchronous network activity in the Tg2576 mouse model of Alzheimer’s disease

The cognitive reserve hypothesis claims that the brain can overcome pathology by reinforcing preexistent processes or by developing alternative cognitive strategies. Epidemiological studies have revealed that this reserve can be built throughout life experiences as education or leisure activities. We previously showed that an early transient environmental enrichment (EE) durably improves memory performances in the Tg2576 mouse model of Alzheimer’s disease (AD). Recently, we evidenced a hypersynchronous brain network activity in young adult Tg2576 mice. As aberrant oscillatory activity can contribute to memory deficits, we wondered whether the long-lasting memory improvements observed after EE were associated with a reduction of neuronal network hypersynchrony. Thus, we exposed non-transgenic (NTg) and Tg2576 mice to standard or enriched housing conditions for 10 weeks, starting at 3 months of age. Two weeks after EE period, Tg2576 mice presented similar seizure susceptibility to a GABA receptor antagonist. Immediately after and 2 weeks after this enrichment period, standard and enriched-housed Tg2576 mice did not differ with regards to the frequency of interictal spikes on their electroencephalographic (EEG) recordings. Thus, the long-lasting effect of this EE protocol on memory capacities in Tg2576 mice is not mediated by a reduction of their cerebral aberrant neuronal activity at early ages.
The Vineyard Yeast Microbiome, a Mixed Model Microbial Map

Vineyards harbour a wide variety of microorganisms that play a pivotal role in pre- and post-harvest grape quality and will contribute significantly to the final aromatic properties of wine. The aim of the current study was to investigate the spatial distribution of microbial communities within and between individual vineyard management units. For the first time in such a study, we applied the Theory of Sampling (TOS) to sample gapes from adjacent and well established commercial vineyards within the same terroir unit and from several sampling points within each individual vineyard. Cultivation-based and molecular data sets were generated to capture the spatial heterogeneity in microbial populations within and between vineyards and analysed with novel mixed-model networks, which combine sample correlations and microbial community distribution probabilities. The data demonstrate that farming systems have a significant impact on fungal diversity but more importantly that there is significant species heterogeneity between samples in the same vineyard. Cultivation-based methods confirmed that while the same oxidative yeast species dominated in all vineyards, the least treated vineyard displayed significantly higher species richness, including many yeasts with biocontrol potential. The cultivatable yeast population was not fully representative of the more complex populations seen with molecular methods, and only the molecular data allowed discrimination amongst farming practices with multivariate and network analysis methods. Importantly, yeast species distribution is subject to significant intra-vineyard spatial fluctuations and the frequently reported heterogeneity of tank samples of grapes harvested from single vineyards at the same stage of ripeness might therefore, at least in part, be due to the differing microbiota in different sections of the vineyard.
Effects of thyroxine on the expression of alcohol dehydrogenase in rat liver and kidney

We studied the effect of thyroxine on alcohol dehydrogenase activity, immunoreactive protein levels and messenger RNA levels in the livers of thyroidectomized and sham‐operated male rats. Effects on kidney alcohol dehydrogenase activity were also examined. Shamoperated rats injected with 100 μg thyroxine/kg/day, which induced hyperthyroidism, showed a 30% decrease in liver and a 40% decrease in kidney alcohol dehydrogenase activity compared with sham‐operated rats injected with vehicle. Hypothyroid rats exhibited a 1.5‐fold increase in alcohol dehydrogenase activity in liver and kidney compared with thyroidectomized rats injected with a replacement dose of 20 μg thyroxine/kg/day. We saw a twofold and a 2.5‐fold higher level of alcohol dehydrogenase activity in liver and kidney, respectively, of hypothyroid rats compared with hyperthyroid rats. These effects were not accounted for by nutritional differences; daily food intake did not differ between groups. Immunoreactive protein levels as seen on Western blots varied in the same direction as enzyme activity. Northern‐blot analysis showed higher levels of liver alcohol dehydrogenase messenger RNA in hypothyroid rats compared with euthyroid rats. These studies show that liver alcohol dehydrogenase activity and protein levels are modulated by thyroxine at pathophysiologically relevant levels and that this effect is not due to changes in food intake; kidney alcohol dehydrogenase activity is regulated in parallel. The change in alcohol dehydrogenase activity appears to be controlled in part by pretranslational mechanisms in hypothyroid animals and by posttranslational mechanisms in hyperthyroid animals. (HEPATOLOGY 1993;17:701–706.)
Processing of yttrium-doped barium zirconate for high proton conductivity

The factors governing the transport properties of yttrium-doped barium zirconate (BYZ) have been explored, with the aim of attaining reproducible proton conductivity in well-densified samples. It was found that a small initial particle size (50–100 nm) and high-temperature sintering (1600 °C) in the presence of excess barium were essential. By this procedure, BaZr_0. 8Y_0. 2O_3−δ with 93% to 99% theoretical density and total (bulk plus grain boundary) conductivity of 7.9 × 10^−3 S/cm at 600 °C [as measured by alternating current (ac) impedance spectroscopy under humidified nitrogen] could be reliably prepared. Samples sintered in the absence of excess barium displayed yttria-like precipitates and a bulk conductivity that was reduced by more than 2 orders of magnitude.
Associations between HIV-related injection behaviour and distance to and patterns of utilisation of syringe-supply programmes

Background: Studies indicate that needle-exchange programmes (NEPs) can reduce the incidence of HIV infection; however, a positive impact of syringe-supply programmes has not been consistently demonstrated. The associations between high-risk injection behaviour and distance to and patterns of utilisation of syringe-supply programmes in injection drug users (IDUs) were investigated. Methods: Participants in a cohort of IDUs (n = 456) residing in Montreal were interviewed between 2004 and 2006. Behavioural questionnaires were administered by trained interviewers, and venous blood samples were drawn and tested for HIV antibodies. The distance from regular IDU dwelling places to nearest NEP or pharmacy was calculated using a Geographic Information System. Logistic regression was used to assess relations with high-risk injection behaviour. Results: Associations between high-risk injection behaviour and distance to syringe-supply source were not linear. The odds of high-risk behaviour grew modestly as distance from the NEP site increased to 1600 m, followed by a flat trend to 3000 m, and thereafter decreased with distance beyond this point. The odds of high-risk behaviour dropped sharply for the relatively few IDUs residing 1 km or more from the nearest pharmacy but this measure was not strongly associated with the outcome. IDUs who exclusively acquired syringes at NEPs or pharmacies had less than half the odds of reporting high-risk injection behaviour than IDUs with inconsistent syringe-access patterns. Conclusions: The study confirms that Montreal NEPs were implemented where they are most needed. These results also suggest that sterile syringe acquisition patterns might influence high-risk injection behaviour.
Finding Missing Interactions of the Arabidopsis thaliana Root Stem Cell Niche Gene Regulatory Network

Over the last few decades, the Arabidopsis thaliana root stem cell niche (RSCN) has become a model system for the study of plant development and stem cell niche dynamics. Currently, many of the molecular mechanisms involved in RSCN maintenance and development have been described. A few years ago, we published a gene regulatory network (GRN) model integrating this information. This model suggested that there were missing components or interactions. Upon updating the model, the observed stable gene configurations of the RSCN could not be recovered, indicating that there are additional missing components or interactions in the model. In fact, due to the lack of experimental data, GRNs inferred from published data are usually incomplete. However, predicting the location and nature of the missing data is a not trivial task. Here, we propose a set of procedures for detecting and predicting missing interactions in Boolean networks. We used these procedures to predict putative missing interactions in the A. thaliana RSCN network model. Using our approach, we identified three necessary interactions to recover the reported gene activation configurations that have been experimentally uncovered for the different cell types within the RSCN: (1) a regulation of PHABULOSA to restrict its expression domain to the vascular cells, (2) a self-regulation of WOX5, possibly by an indirect mechanism through the auxin signaling pathway, and (3) a positive regulation of JACKDAW by MAGPIE. The procedures proposed here greatly reduce the number of possible Boolean functions that are biologically meaningful and experimentally testable and that do not contradict previous data. We believe that these procedures can be used on any Boolean network. However, because the procedures were designed for the specific case of the RSCN, formal demonstrations of the procedures should be shown in future efforts.
Availability and Use of Informational Texts in Second-, Third-, and Fourth-Grade Classrooms

A sharp increase in the proportion of informational text with the corresponding expansion of cognitive demands and conceptual structures is a widely held explanation for the decline inreading achievement at the fourth-grade level. In this study, differences in the proportion of informational text across the second, third, and fourth grades were examined in order to determine if this perennial explanation for the fourth-grade slump was supported. Available print materials in 15 classrooms (5 per grade) and time spent with texts in written language activities were coded and analyzed by text type following Duke’s (2000) data-collection procedures. The proportion of informational text in classrooms was slightly higher in grade 2; in classroom environmental print it was highest in grade 3, followed by grade 4 and then grade 2; in classroom written language activities it showed a marked increase from grades 2 to 3, with that increase sustained in grade 4. Total instructional time with informational text was an average of 1 minute in grade 2 and 16 minutes in grades 3 and 4. The most common instructional activities with informational text were reading to complete a worksheet and round-robin reading.
Arousal and Valence Recognition of Affective Sounds Based on Electrodermal Activity

Physiological sensors and interfaces for mental healthcare are becoming of great interest in research and commercial fields. Specifically, biomedical sensors and related ad hoc signal processing methods can be profitably used for supporting objective, psychological assessments. However, a simple system able to automatically classify the emotional state of a healthy subject is still missing. To overcome this important limitation, we here propose the use of convex optimization-based electrodermal activity (EDA) framework and clustering algorithms to automatically discern arousal and valence levels induced by affective sound stimuli. EDA recordings were gathered from 25 healthy volunteers, using only one EDA sensor to be placed on fingers. Standardized stimuli were chosen from the International Affective Digitized Sound System database, and grouped into four different levels of arousal (i.e., the levels of emotional intensity) and two levels of valence (i.e., how unpleasant/pleasant a sound can be perceived). Experimental results demonstrated that our system is able to achieve a recognition accuracy of 77.33% on the arousal dimension, and 84% on the valence dimension.