Miracle-dz/UniFAR-FTUs huggingface dataset:
Metabolic Hyperactivity of the Medial Posterior Parietal Lobes in Psychogenic Tremor

Background The pathophysiology of psychogenic movement disorders, including psychogenic tremor (PT), is only emerging. Case Report This is a single case report of a patient who met diagnostic criteria for PT. He underwent positron emission tomography (PET) of brain with 18F-deoxyglucose at resting state. His PET study showed symmetrically increased 18F-deoxyglucose uptake in both posterior medial parietal lobes. There was no corresponding abnormality on structural imaging. Discussion Hypermetabolism of the medial aspects of posterior parietal lobes bilaterally may reflect abnormal activity of sensory integration that is important in the pathogenesis of PT. This further supports the idea that non-organic movement disorders may be associated with detectable functional brain abnormalities.
Klebsiella pneumoniae Carbapenemase (KPC)-Producing K. pneumoniae at a Single Institution: Insights into Endemicity from Whole-Genome Sequencing

ABSTRACT The global emergence of Klebsiella pneumoniae carbapenemase-producing K. pneumoniae (KPC-Kp) multilocus sequence type ST258 is widely recognized. Less is known about the molecular and epidemiological details of non-ST258 K. pneumoniae in the setting of an outbreak mediated by an endemic plasmid. We describe the interplay of blaKPC plasmids and K. pneumoniae strains and their relationship to the location of acquisition in a U.S. health care institution. Whole-genome sequencing (WGS) analysis was applied to KPC-Kp clinical isolates collected from a single institution over 5 years following the introduction of blaKPC in August 2007, as well as two plasmid transformants. KPC-Kp from 37 patients yielded 16 distinct sequence types (STs). Two novel conjugative blaKPC plasmids (pKPC_UVA01 and pKPC_UVA02), carried by the hospital index case, accounted for the presence of blaKPC in 21/37 (57%) subsequent cases. Thirteen (35%) isolates represented an emergent lineage, ST941, which contained pKPC_UVA01 in 5/13 (38%) and pKPC_UVA02 in 6/13 (46%) cases. Seven (19%) isolates were the epidemic KPC-Kp strain, ST258, mostly imported from elsewhere and not carrying pKPC_UVA01 or pKPC_UVA02. Using WGS-based analysis of clinical isolates and plasmid transformants, we demonstrate the unexpected dispersal of blaKPC to many non-ST258 lineages in a hospital through spread of at least two novel blaKPC plasmids. In contrast, ST258 KPC-Kp was imported into the institution on numerous occasions, with other blaKPC plasmid vectors and without sustained transmission. Instead, a newly recognized KPC-Kp strain, ST941, became associated with both novel blaKPC plasmids and spread locally, making it a future candidate for clinical persistence and dissemination.
A Performance Evaluation of Buffer Management and Scheduling for ATM- GFR Using TCP

Among the various categories of ATM (Asynchronous Transfer Mode) service, ABR (Available Bit Rate) and UBR (Unspecified Bit Rate) have been introduced to support data traffic (such as TCP). GFR (Guarantee Frame Rate) is the current proposed ATM service to provide better performance for data traffic over ATM. The aim of this paper is two-folded. Firstly, we characterise the major research issues in GFR and draw upon the published works to illustrate some of the critical issues about the specification and the possible alternatives of its implementation. Secondly, we undertake a performance evaluation of ATM-GFR’s buffer management algorithms (two-static-threshold scheme and per-VC accounting) and scheduling (FIFO (First In First Out) and WFQ (Weighted Fair Queue)). The simulation results have shown that two-static-threshold-buffermanagement and per-VC-buffer management give the best performance comparing with plain UBR, UBREPD and per-VC scheduling. We also found that the two-threshold buffer management scheme is significant to handle CLP0+1 traffic. This scheme can distinguish between the tagged (low priority) and untagged (high priority) packets of the traffic and protect the bandwidth from flushing by tagged packets. The per-VC scheduling without the sensitivity of tagged/untagged frames can lead to the poor performance for untagged (high priority) packets.
Gene Expression Profile of the A549 Human Non-Small Cell Lung Carcinoma Cell Line following Treatment with the Seeds of Descurainia sophia, a Potential Anticancer Drug

Descurainia sophia has been traditionally used in Korean medicine for treatment of diverse diseases and their symptoms, such as cough, asthma, and edema. Our previous results showed that ethanol extract of the seeds of D. sophia (EEDS) has a potent cytotoxic effect on human cancer cells. In this study, we reveal the molecular events that are induced by EEDS treatment in A549 human lung cancer cells. The dose-dependent effect of EEDS on gene expression was measured via a microarray analysis. Gene ontology and pathway analyses were performed to identify functional involvement of genes regulated by EEDS. From gene expression analyses, two major dose-dependent patterns were observed after EEDS treatment. One pattern consisted of 1,680 downregulated genes primarily involved in metabolic processes (FDR < 0.01). The second pattern consisted of 1,673 upregulated genes primarily involved in signaling processes (FDR < 0.01). Pathway activity analyses revealed that the metabolism-related pathways and signaling-related pathways were regulated by the EEDS in dose-dependent and reciprocal manners. In conclusion, the identified biphasic regulatory mechanism involving activation of signaling pathways may provide molecular evidence to explain the inhibitory effect of EEDS on A549 cell growth.
Synthesis of averaged circuit models for switched power converters

Averaged circuit models for switching converters are developed using a direct circuit averaging method. The method proceeds in a systematic fashion by determining appropriate averaged circuit elements that are consistent with the averaged circuit waveforms. The averaged circuit models that are obtained are synthesis of the state-space averaged models for the underlying switched circuits. An important feature of the method is that it is applicable to switched circuits whose nonswitch elements may be nonlinear. The results obtained using this method are compared with the results on averaged circuit models available in the literature. <<ETX>>
Unemployment, Temporary Work, and Subjective Well-Being: The Gendered Effect of Spousal Labor Market Insecurity

The negative impact of unemployment on individuals and its spillover to spouses is widely documented. However, we have a gap in our knowledge when it comes to the similar consequences of temporary employment. This is problematic, because although temporary jobs are often considered better alternatives to unemployment for endowing individuals with income and opportunities to connect to employers, they are also associated with stressors such as high levels of job insecurity and poor quality work, the effects of which might spill over to spouses. Using matched data from the British Household Panel Study, I show that temporary work is at least as detrimental as unemployment for spouses’ subjective well-being, although there are differences. When experienced by husbands, temporary work, like unemployment, has a negative effect on wives’ psychological well-being and life satisfaction. Yet, as opposed to unemployment, wives’ temporary employment also spills over and negatively affects husbands’ psychological well-being. Furthermore, coupled individuals’ well-being is most affected when men are either unemployed or temporarily employed and their wives have permanent jobs, suggesting that the effect is related to gender deviation. The effects are robust after controlling for fixed individual characteristics that can influence both employment status and well-being outcomes.
Autoregressive (AR) spectral estimates for Frequency- Wavenumber (F-k) analysis of strong-motion data

Frequency-wavenumber (F-k) spectra of seismic strong-motion array data are useful in estimating the backazimuth and apparent propagation velocity of seismic waves arriving at the array. Such estimates are required to model the wave passage effects while studying spatial variability of strong ground motions. Traditionally, F-k spectral computation is based on windowed periodogram estimates of spectral matrices. We present an alternative spectral estimate based on the well-known Autoregressive (AR) model. Such spectral estimates are found to be smoother than the windowed periodogram estimates, and can be directly used in F-k spectral analysis. We present an example application of the proposed technique using strong-motion data recorded by the SMART-1 array in Taiwan during the January 29 1981 ML 6.3 earthquake. Our results, in terms of backazimuth and apparent propagation velocity, are found to be in excellent agreement with those reported in the literature.
Electric Differential With Svpwm Direct Torque Control Using Five-Leg Inverter For Electric Vehicles

The stability control of two separate electric vehicle (EV) motors by using only single five-leg inverter (FLI) is the motivation of this study. This paper proposes an electric differential (ED) in a FLI to serve dual separate induction motor (IM) drive-based wheels of an EV traction drive system. FLI is developed to replace the two normal three-phase voltage source inverters that need to independently control the two separate IMs at each of the EV wheels. Stability problem will be tackled by electric differential (ED) algorithm. The proposed traction drive employs space vector pulse width modulation direct torque control (SVPWM DTC) modulator with duty cycle merging algorithm as the switching sequence of the FLI. This technique allowed any portion of DC bus voltage to be allocated to any motor. Simulations were performed. The resulting control performance; speed, torque, and current verified the stability and robustness of the system. This study implies that there is possibility of using only one inverter (FLI) in order to drive two separate IM drive-based wheels without jeopardizes the system stability and robustness.
AIRS: Supporting Interactive Real-Time Applications on Multicore Platforms

Modern real-time systems increasingly operate with multiple interactive applications. While these systems often require reliable quality of service (QoS) for the applications, even under heavy workloads, many existing CPU schedulers are not very capable of satisfying such requirements. In this paper, we design and implement an Advanced Interactive and Real-time Scheduler, called AIRS. AIRS is aimed at supporting systems that run multiple interactive real-time applications, particularly on multicore platforms. It provides a new CPU reservation mechanism to enhance the QoS of the overall system. The reservation algorithm is based on the prior Constant Bandwidth Server (CBS) algorithm, but is more flexible and efficient, when multiple applications reserve CPU bandwidth. It also provides a new multicore scheduler to improve the absolute CPU bandwidth available for the applications to perform well. The scheduling algorithm is subject to the prior Earliest Deadline First with Window-constraint Migration (EDF-WM) algorithm, but is extended to work with the new CPU reservation mechanism. Experimental evaluation shows that AIRS delivers higher quality to simultaneous playback of multiple movies than the existing real-time scheduler. It also demonstrates that AIRS offers hard timing guarantees for randomly-generated task sets with heavy workloads.
Necessary and Sufficient Conditions for Differentiating Under the Integral Sign

absolute convergence, the condition Ifi (x, y)I R is continuous on [a, b] and differentiable on (a, b) it is not always the case that g' is Riemann or Lebesgue integrable over [a, b]. H4owever, the Henstock integral integrates all derivatives and thus leads to the most complete version of the Fundamental Theorem of Calculus. The Henstock integral's definition in terms of Riemann sums is only slightly more complicated than for the Riemann integral (simpler than the improper Riemann integral), yet it includes the Riemann, improper Riemann, and Lebesgue integrals as special cases. Using the very strong version of the Fundamental Theorem we can formulate necessary and sufficient conditions for differentiating under the integral sign.
Comparison of pemetrexed plus cisplatin with gemcitabine plus docetaxel in refractory/metastatic osteosarcoma: Clinical outcomes from a retrospective database monitored in a single institute

The prognosis for patients with relapsed/metastatic osteosarcoma is poor and the optimal treatment strategy remains to be refined. Whilst gemcitabine plus docetaxel combination treatment has already been demonstrated to have certain promising results in the treatment of osteosarcoma, the use of pemetrexed, a multi-targeted antifolate, remains controversial. In the present study, a retrospective investigation was conducted to evaluate the toxicity and efficacy of the pemetrexed plus cisplatin combination in relapsed/metastatic osteosarcoma. Comparison of this treatment with that of the gemcitabine plus docetaxel combination was also conducted. Clinical data from 39 patients suffering from refractory/metastatic osteosarcoma between January 2005 and May 2011 were reviewed retrospectively. Of these patients, 21 were administered the gemcitabine plus docetaxel combination, and 18 were provided the pemetrexed plus cisplatin combination. Treatment was continued until the occurrence of disease progression or unacceptable toxicity. In the gemcitabine plus docetaxel group, the overall response rate and disease control rate were found to be 9.5 and 28.5% respectively, compared with 5.5 and 33.3% respectively in the pemetrexed plus cisplatin group. The median progression-free survival (PFS) time was found to be 1.8 months for both the gemcitabine plus docetaxel and pemetrexed plus cisplatin groups. The median overall survival (OS) time was 6 months in the gemcitabine plus docetaxel group and 7 months in the pemetrexed plus cisplatin group. No statistically significant differences were recognized between the overall response rates, disease control rates, PFS times and OS times in the two groups. The two combinations appeared to be well tolerated. However, the incidence of grade 3/4 thrombocytopenia and leucopenia was higher in the gemcitabine plus docetaxel group than in the pemetrexed plus cisplatin group. The present study clearly demonstrated that both chemo-combinations were well-tolerated and exerted antitumor activity in patients with refractory/metastatic osteosarcoma. However, with regard to grade 3/4 toxicity, the pemetrexed plus cisplatin chemotherapy appears to be better tolerated.
University halls plastics recycling: a blended intervention study

Purpose The problem of plastic wastes is serious nowadays worldwide, although plastic wastes recycling is already in practice. To promote sustainability in plastic waste recycling, the quality of wastes collected should be maintained well, resulted from a good recycling practice. This paper aims to study a new plastic recycling bin (PRB) and poster interventions on the enhancement of university hall residential students’ proenvironmental knowledge, attitudes and intended behaviours (KAB) and actual recycling behaviours; informative and feedback posters were used as interventions. Design/methodology/approach This study adopted a quasi-experimental setting to examine the effects of the new PRB on students’ KAB and actual behaviours in recycling, whereas the quality of the recycled plastic was measured according to the extent of cleanliness (CLE), separation (SEP), compression (COM) and sortedness (SOR). Findings Results showed that significant positive enhancements in KAB only happened with the use of blended interventions, which included promotion through the PRB and posters, suggesting that the use of the PRB and posters was useful in achieving better recycling behaviour. Originality/value Blended intervention study by using new design plastic recycling bin and poster on the effect of students’ proenvironmental and recycling KAB.
A Combinatorial Fusion Method for Feature Mining

This paper demonstrates how methods borrowed from information fusion can improve the performance of a classifier by constructing (“fusing”) new features that are combinations of existing numeric features. This work is an example of local pattern analysis and fusion because it identifies potentially useful patterns (i.e., feature combinations) from a single data source. In our work, we fuse features by mapping the numeric values for each feature to a rank and then averaging these ranks. The quality of the fused features is measured with respect to how well they classify minority-class examples, which makes this method especially effective for dealing with data sets that exhibit class imbalance. This paper evaluates our combinatorial feature fusion method on ten data sets, using three learning methods. The results indicate that our method can be quite effective in improving classifier performance, although it seems to improve the performance of some learning methods more than others. General Terms Algorithms, Performance, Experimentation
Influence of a Short-Term Iron-Deficient Diet on Hepatic Gene Expression Profiles in Rats

Iron is an essential mineral for the body, and iron deficiency generally leads to anemia. However, because non-anemic iron deficiency can exist, we performed a comprehensive transcriptome analysis of the liver to define the effects of this condition on the body. Four-week-old male rats were fed a low-iron diet (approximately 3 ppm iron) for 3 days and compared with those fed a normal diet (48 ppm iron) by pair feeding as a control. The rats in the iron-deficient diet group developed a non-anemic iron-deficient state. DNA microarray analysis revealed that during this short time, this state conferred a variety of effects on nutrient metabolism in the liver. In comparison with long-term (17 days) iron-deficiency data from a previous study, some of the changed genes were found to be common to both short- and long-term iron deficiency models, some were specific to the short-term iron deficiency model, and the others were oppositely regulated between the two feeding terms. Taken together, these data suggest that although the blood hemoglobin level itself remains unchanged during non-anemic iron deficiency, a variety of metabolic processes involved in the maintenance of the energy balance are altered.
A Continuous Toroidal Winding SRM With 6- or 12-Switch DC Converter

A new toroidally wound switched reluctance machine (TSRM) with a single continuous multitapped winding is presented. This machine may be driven by a 6-switch asymmetric converter that supplies unipolar coil currents or by a 12-switch voltage source converter that supplies bipolar coil currents. The TSRM magnetic design and power electronic control is described, and its performance is compared with a conventional switched reluctance motor (CSRM) and with a previously reported toroidal format switched reluctance machine that utilizes six discrete winding coils in a three-phase wye connection (WSRM) driven by a voltage source inverter. A fixed 6-4 CSRM magnetic circuit design is selected for the comparative analysis of the three machine topologies by static and dynamic finite-element simulations.
Protein kinase CK2 phosphorylates and activates p21-activated kinase 1

P21-activated kinase 1 (PAK1) activation is achieved through relief of autoinhibition. The authors show that this event is not sufficient to bring about PAK1 activation but is required for CK2-dependent PAK1S223 phosphorylation, which enables PAK1 to be catalytically competent. S223 phosphorylation is crucial for PAK1 GTPase-dependent and GTPase-independent activation.
Let’s go out for a drink after work! The relation between leisure time spent with colleagues and employees’ life satisfaction

ABSTRACT Despite the tremendous research studying the factors that influence employees’ well-being, the effect of what happens when leisure time is spent with colleagues remains yet unexamined. Building on the conservation of resources theory, we propose that leisure time spent with colleagues could be understood as a resource, especially for those individuals who have few friends at their workplace. In a cross-sectional design, 136 university employees provided information about the number of friends they have at work, the amount of leisure time spent with befriended colleagues, and their life satisfaction. Results suggest that a larger network of friends at work is positively associated with life satisfaction. Furthermore, the effect of the number of friends at work on life satisfaction is moderated by the amount of leisure time spent with befriended colleagues. Employees who have few friends at work report more life satisfaction, if they spend more leisure time with befriended colleagues, whereas such an effect was not found for employees with a large friend network at work. These results are placed into the context of current discussions about work-life-blending.
A Novel Approach for Efficient Resource Consumption in GPS-Based Mobile IPv6 Wireless LAN

Seamless handover has become an important challenging issue among research groups over the past 5 years. Researchers and scientists have been making efforts to provide robust and integrated connectivity while the mobile node (MN) moves between networks. Running certain procedures such as movement detection (MD), neighbor discovery (ND), duplicate address detection (DAD) and sending binding updates (Bus) are needed in order to achieve complete handover procedure which results in handover latency and eventually packet loss. Recently, scientists have found that by utilizing information provided by the Global Positioning System (GPS) device, it is possible to reduce the amount of handover latency by decreasing the amount of time consumed by MD, ND and DAD procedures. In this paper we are going to investigate the proposed GPS models and their effects on the handover procedure in the MIPv6 protocol.
Activity recognition using a wrist-worn inertial measurement unit: A case study for industrial assembly lines

As wearable sensors are becoming more common, their utilization in real-world applications is also becoming more attractive. In this study, a single wrist-worn inertial measurement unit was attached to the active wrist of a worker and acceleration and angular speed information was used to decide what activity the worker was performing at certain time intervals. This activity information can then be used for proactive instruction systems or to ensure that all the needed work phases are performed. In this study, the selected activities were basic tasks of hammering, screwing, spanner use and using a power drill for screwing. In addition, a null activity class consisting of other activities (moving around the post, staying still, changing tools) was defined. The performed activity could then be recognized online by using a sliding window method to divide the data into two-second intervals and overlapping two adjacent windows by 1.5 seconds. Thus, the activity was recognized every half second. The method used for the actual recognition was the k nearest neighbor method with a specific distance boundary for classifying completely new events as null data. In addition, the final class was decided by using a majority vote to classifications of three adjacent windows. The results showed that almost 90 percent accuracy can be achieved with this kind of setting; the activity-specific accuracies for hammering, screwing, spanner use, power drilling and null data were 96.4%, 89.7%, 89.5%, 77.6% and 89.0%, respectively. In addition, in a case with completely new null events, use of the specific distance measure improved accuracy from 68.6% to 82.3%.