Miracle-dz/UniFAR-FTUs huggingface dataset:
Rey-Osterrieth Complex Figure - copy and immediate recall (3 minutes): Normative data for Spanish-speaking pediatric populations.

OBJECTIVE To generate normative data for the Rey-Osterrieth Complex Figure (ROCF) in Spanish-speaking pediatric populations. METHOD The sample consisted of 4,373 healthy children from nine countries in Latin America (Chile, Cuba, Ecuador, Guatemala, Honduras, Mexico, Paraguay, Peru, and Puerto Rico) and Spain. Each participant was administered the ROCF as part of a larger neuropsychological battery. The ROCF copy and immediate recall (3 minutes) scores were normed using multiple linear regressions and standard deviations of residual values. Age, age2, sex, and mean level of parental education (MLPE) were included as predictors in the analyses. RESULTS The final multiple linear regression models showed main effect for age on copy and immediate recall scores, such that scores increased linearly as a function of age. Age2 affected ROCF copy score for all countries, except Puerto Rico; and ROCF immediate recall scores for all countries, except Chile, Guatemala, Honduras, Paraguay, and Puerto Rico. Models indicated that children whose parent(s) had a MLPE >12 years obtained higher scores compared to children whose parent(s) had a MLPE≤12 years for Chile, Puerto Rico, and Spain in the ROCF copy, and Paraguay and Spain for the ROCF immediate recall. Sex affected ROCF copy and immediate recall score for Chile and Puerto Rico with girls scoring higher than boys. CONCLUSIONS This is the largest Spanish-speaking pediatric normative study in the world, and it will allow neuropsychologists from these countries to have a more accurate approach to interpret the ROCF Test in pediatric populations.
Convergence of a finite volume scheme for the convection-diffusion equation with L1 data

In this paper, we prove the convergence of a finite-volume scheme for the time-dependent convection–diffusion equation with an L 1 right-hand side. To this purpose, we first prove estimates for the discrete solution and for its discrete time and space derivatives. Then we show the convergence of a sequence of discrete solutions obtained with more and more refined discretiza-tions, possibly up to the extraction of a subsequence, to a function which mets the regularity requirements of the weak formulation of the problem; to this purpose, we prove a compactness result, which may be seen as a discrete analogue to Aubin-Simon's lemma. Finally, such a limit is shown to be indeed a weak solution.
Psychedelics and the essential importance of context

Psychedelic drugs are making waves as modern trials support their therapeutic potential and various media continue to pique public interest. In this opinion piece, we draw attention to a long-recognised component of the psychedelic treatment model, namely ‘set’ and ‘setting’ – subsumed here under the umbrella term ‘context’. We highlight: (a) the pharmacological mechanisms of classic psychedelics (5-HT2A receptor agonism and associated plasticity) that we believe render their effects exceptionally sensitive to context, (b) a study design for testing assumptions regarding positive interactions between psychedelics and context, and (c) new findings from our group regarding contextual determinants of the quality of a psychedelic experience and how acute experience predicts subsequent long-term mental health outcomes. We hope that this article can: (a) inform on good practice in psychedelic research, (b) provide a roadmap for optimising treatment models, and (c) help tackle unhelpful stigma still surrounding these compounds, while developing an evidence base for long-held assumptions about the critical importance of context in relation to psychedelic use that can help minimise harms and maximise potential benefits.
Breathing easy: A prospective study of optimism and pulmonary function in the normative aging study

Although there is good evidence that emotions are associated with chronic airways obstruction, evidence for the influence of psychological factors on the level and decline of pulmonary function is sparse. Optimism has been linked to enhanced well-being, whereas pessimism has been identified as a risk factor for poor physical health. This investigation examines prospectively the effects of optimism versus pessimism on pulmonary function. Data are from the Veterans Administration Normative Aging Study, an ongoing cohort of older men. In 1986, 670 men completed the revised Minnesota Multiphasic Personality Inventory from which we derived the bipolar Revised Optimism-Pessimism Scale. During an average of 8 years of follow-up, an average of 3 pulmonary function exams were obtained. Men with a more optimistic explanatory style had significantly higher levels of forced expiratory volume in 1 sec (FEV1) and forced vital capacity (both p > .01). Interactions between time and optimism suggested that rate of decline in FEV1 over time was slower in men with a more optimistic explanatory style relative to men who were more pessimistic. These data are the first to link optimism with higher levels of pulmonary function and slower rate of pulmonary function decline in older men, a protective effect that is independent of smoking.
A Psychoacoustic Model of Harmonic Cadences: A Preliminary Report

This report presents a psychoacoustically derived computational model of the perceived distance between any two major or minor triads, the degree of activity created by any given pair of triads, and the cadential effectiveness of three-triad progressions. It also provides statistical analyses of the ratings given by thirty-five participants for the "similarity" and "fit" of triads in a pair, and the "cadential effectiveness" of three-triad progressions. Multiple regressions show that the model provides highly significant predictions of the experimentally obtained ratings. Finally, it is argued that because the model is based upon psychoacoustic axioms, it is likely the regression equations represent true causal models. As such, the computational model and its associated theory question the plausibility of theoretical approaches to tonality that use only long-term memory and statistical features, as well as those approaches based upon symmetrical geometrical structures like the torus. It is hoped that the psychoacoustic approach proposed here may herald not only the return of psychoacoustic approaches to tonal music theory, but also the exploration of the tonal possibilities offered by non-standard tunings and non-harmonic timbres.
Poorer Subjective Sleep Quality Is Related to Higher Fantasy-Induced Sexual Arousal in Women of Reproductive Age

Lack of sleep enhances erections and lubrication the next day. This raises the possibility that poorer subjective sleep quality is related to sexual arousal. To test this hypothesis, sexual arousal was elicited in 70 Portuguese women of reproductive age by means of fantasy. The level of salivary testosterone before and shortly after fantasy was determined by luminescence immunoassays. Participants completed the Pittsburgh Sleep Quality Index (PSQI), reported their sexual arousal before and during fantasy, and how anxious they were after the fantasy. The hypothesis was confirmed. Anxiety did not explain the association, but testosterone response (poststimulus minus baseline) had a slight explanatory effect.
The Dual Route to Value Change: Individual Processes and Cultural Moderators

Understanding value stability and change is essential for understanding values of both individuals and cultures.Yet theoretical thinking and empirical evidence on this topic have been scarce. In this article, the authors suggest a model outlining processes of individual value change. This model proposes that value change can occur through automatic and effortful routes. They identify five facilitators of value change (priming, adaptation, identification, consistency maintenance, and direct persuasion) and consider the moderating role of culture in each. In addition, the authors discuss the roles of culture, personal values, and traits as general moderators of value change. Evidence on the structure of value change and the effects of age on value change are also reviewed.
Recommendation in heterogeneous information networks with implicit user feedback

Recent studies suggest that by using additional user or item relationship information when building hybrid recommender systems, the recommendation quality can be largely improved. However, most such studies only consider a single type of relationship, e.g., social network. Notice that in many applications, the recommendation problem exists in an attribute-rich heterogeneous information network environment. In this paper, we study the entity recommendation problem in heterogeneous information networks. We propose to combine various relationship information from the network with user feedback to provide high quality recommendation results. The major challenge of building recommender systems in heterogeneous information networks is to systematically define features to represent the different types of relationships between entities, and learn the importance of each relationship type. In the proposed framework, we first use meta-path-based latent features to represent the connectivity between users and items along different paths in the related information network. We then define a recommendation model with such latent features and use Bayesian ranking optimization techniques to estimate the model. Empirical studies show that our approach outperforms several widely employed implicit feedback entity recommendation techniques.
Use of amyloid-PET to determine cutpoints for CSF markers

Objectives: To define CSF β-amyloid 1–42 (Aβ42) cutpoints to detect cortical amyloid deposition as assessed by 11C-Pittsburgh compound B ([11C]PiB)-PET and to compare these calculated cutpoints with cutpoints currently used in clinical practice. Methods: We included 433 participants (57 controls, 99 with mild cognitive impairment, 195 with Alzheimer disease [AD] dementia, and 82 with non-AD dementia) from 5 European centers. We calculated for each center and for the pooled cohort CSF Aβ42 and Aβ42/tau ratio cutpoints for cortical amyloid deposition based on visual interpretation of [11C]PiB-PET images. Results: Amyloid-PET–based calculated CSF Aβ42 cutpoints ranged from 521 to 616 pg/mL, whereas existing clinical-based cutpoints ranged from 400 to 550 pg/mL. Using the calculated cutpoint from the pooled sample (557 pg/mL), concordance between CSF Aβ42 and amyloid-PET was 84%. Similar concordance was found when using a dichotomized Aβ42/tau ratio. Exploratory analysis showed that participants with a positive amyloid-PET and normal CSF Aβ42 levels had higher CSF tau and phosphorylated tau levels and more often had mild cognitive impairment or AD dementia compared with participants who had negative amyloid-PET and abnormal CSF Aβ42 levels. Conclusions: Amyloid-PET–based CSF Aβ42 cutpoints were higher and tended to reduce intercenter variability compared with clinical-based cutpoints. Discordant participants with normal CSF Aβ42 and a positive amyloid-PET may be more likely to have AD-related amyloid pathology than participants with abnormal CSF Aβ42 and a negative amyloid-PET. Classification of evidence: This study provides Class II evidence that an amyloid-PET–based CSF Aβ42 cutpoint identifies individuals with amyloid deposition with a sensitivity of 87% and specificity of 80%.
Multivariate Pattern Classification of Facial Expressions Based on Large-Scale Functional Connectivity

It is an important question how human beings achieve efficient recognition of others’ facial expressions in cognitive neuroscience, and it has been identified that specific cortical regions show preferential activation to facial expressions in previous studies. However, the potential contributions of the connectivity patterns in the processing of facial expressions remained unclear. The present functional magnetic resonance imaging (fMRI) study explored whether facial expressions could be decoded from the functional connectivity (FC) patterns using multivariate pattern analysis combined with machine learning algorithms (fcMVPA). We employed a block design experiment and collected neural activities while participants viewed facial expressions of six basic emotions (anger, disgust, fear, joy, sadness, and surprise). Both static and dynamic expression stimuli were included in our study. A behavioral experiment after scanning confirmed the validity of the facial stimuli presented during the fMRI experiment with classification accuracies and emotional intensities. We obtained whole-brain FC patterns for each facial expression and found that both static and dynamic facial expressions could be successfully decoded from the FC patterns. Moreover, we identified the expression-discriminative networks for the static and dynamic facial expressions, which span beyond the conventional face-selective areas. Overall, these results reveal that large-scale FC patterns may also contain rich expression information to accurately decode facial expressions, suggesting a novel mechanism, which includes general interactions between distributed brain regions, and that contributes to the human facial expression recognition.
Gesture types for functions

This paper reports on the different gesture types employed by twenty-three Year 10 students as they endeavoured to explain their understanding of rate of change associated with the functions resulting from two different computer simulations. These gestures also have application to revealing students’ understanding of functions. However, interpretation of gesture is problematic but classification of gestures assisted in the analysis of the videorecorded interviews probing participants’ conceptions of rate of change. This paper builds on the classifications reported in previous research. Five additional gesture types are presented, which provide insights into students’ thinking about rate of change, and hence functions.
Limited Trabecular Bone Density Heterogeneity in the Human Skeleton

There is evidence for variation in trabecular bone density and volume within an individual skeleton, albeit in a few anatomical sites, which is partly dependent on mechanical loading. However, little is known regarding the basic variation in trabecular bone density throughout the skeleton in healthy human adults. This is because research on bone density has been confined to a few skeletal elements, which can be readily measured using available imaging technology particularly in clinical settings. This study comprehensively investigates the distribution of trabecular bone density within the human skeleton in nine skeletal sites (femur, proximal and distal tibia, third metatarsal, humerus, ulna, radius, third metacarpal, and axis) in a sample of N = 20 individuals (11 males and 9 females). pQCT results showed that the proximal ulna (mean = 231.3 mg/cm3) and axis vertebra (mean = 234.3 mg/cm3) displayed significantly greater (p < 0.01) trabecular bone density than other elements, whereas there was no significant variation among the rest of the elements (p > 0.01). The homogeneity of the majority of elements suggests that these sites are potentially responsive to site-specific genetic factors. Secondly, the lack of correlation between elements (p > 0.05) suggests that density measurements of one anatomical region are not necessarily accurate measures of other anatomical regions.
Effect of LPG Injection Methods on Engine Performance

Three methods of injecting liquefied petroleum gas (LPG) were tested on an LPG engine. The injection methods were gaseous phase LPG injection at intake port, liquid phase LPG injection at intake port, and liquid phase LPG in-cylinder direct injection. The experimental results showed that the maximum torque developed with liquid phase LPG-engine direct injection, was 13.8 percent higher than gaseous phase LPG injection at the intake port. It was found that liquid phase LPG direct injection was an effective way to overcome power deterioration of an LPG-engine as compared to a gaseous phase LPG injection supply method.
Phosphatidylserine transport by Ups2–Mdm35 in respiration-active mitochondria

Phosphatidylethanolamine, an essential phospholipid for mitochondrial functions, is synthesized at the mitochondrial inner membrane. Miyata et al. demonstrate that Ups2–Mdm35, a protein complex in the mitochondrial intermembrane space, mediates phosphatidylserine transport for phosphatidylethanolamine synthesis in respiration-active mitochondria of Saccharomyces cerevisiae.
Patient Characteristics Associated With Severe Hypoglycemia in a Type 2 Diabetes Cohort in a Large, Integrated Health Care System From 2006 to 2015

OBJECTIVE To identify severe hypoglycemia events, defined as emergency department visits or hospitalizations for hypoglycemia, in patients with type 2 diabetes receiving care in a large health system and to identify patient characteristics associated with severe hypoglycemia events. RESEARCH DESIGN AND METHODS This was a retrospective cohort study from January 2006 to December 2015 using the electronic medical record in the Cleveland Clinic Health System (CCHS). Participants included 50,439 patients with type 2 diabetes receiving care in the CCHS. Number of severe hypoglycemia events and associated patient characteristics were identified. RESULTS The incidence proportion of severe hypoglycemia increased from 0.12% in 2006 to 0.31% in 2015 (P = 0.01). Compared with patients who did not experience severe hypoglycemia, those with severe hypoglycemia had similar median glycosylated hemoglobin (HbA1c) levels. More patients with severe hypoglycemia versus those without had a prior diagnosis of nonsevere hypoglycemia (9% vs. 2%, P < 0.001). Logistic regression confirmed an increased odds for severe hypoglycemia with insulin, sulfonylureas, increased number of diabetes medications, history of nonsevere hypoglycemia (odds ratio [OR] 3.01, P < 0.001), HbA1c <6% (42 mmol/mol) (OR 1.95, P < 0.001), black race, and increased Charlson comorbidity index. Lower odds of severe hypoglycemia were noted with higher BMI and use of metformin, dipeptidyl peptidase 4 inhibitors, and glucagon-like peptide 1 agonists. CONCLUSIONS In this retrospective study of patients with type 2 diabetes with severe hypoglycemia, patient characteristics were identified. Patients with severe hypoglycemia had previous nonsevere hypoglycemia diagnoses more frequently than those without. Identifying patients at high risk at the point of care can allow for change in modifiable risk factors and prevention of severe hypoglycemia events.
Green Tea (Camellia sinensis): Hypocholesterolemic Effects in Humans and Anti-Inflammatory Effects in Animals

In its essence, tea is an infusion of Camellia sinensis leaves and it is the most widely consumed beverage in the world, aside water. Animal and epidemiological studies have associated green tea consumption with several health benefits, which include hypocholesterolemic effect and anti-in-flammatory activity. In this study catechins levels of green tea and its effect on the lipid profile of humans were evaluated as well as the protective effects against H2O2-mediated damage in human fibroblasts and anti-inflammatory activity of (–)-epigallocatechingallate (EGCG). The daily consumption of 1200 mL of green tea for 30 days by 15 human volunteers promoted the decrease of cholesterol and LDL levels after 15 days, but this effect was not persistent after 30 days. No changes were observed in lipid profile after the consumption of green tea capsules. EGCG, a major green tea catechin, demonstrated an anti-inflammatory action in rats and an antioxidant effect in cultured human fibroblasts.
T cell activation requires force generation

The T cell receptor requires force for triggering. Here, Hu and Butte show that T cells generate pushing and pulling forces against an antigen-coated AFM cantilever in an actin-dependent fashion. Exogenous, oscillating forces delivered by the cantilever rescued T cell receptor signaling in the absence of an intact F-actin cytoskeleton. These findings highlight the importance of mechanical forces in T cell activation.
Tracking Snow Variations in the Northern Hemisphere Using Multi-Source Remote Sensing Data (2000-2015)

Multi-source remote sensing data were used to generate 500-m resolution cloud-free daily snow cover images for the Northern Hemisphere. Simultaneously, the spatial and temporal dynamic variations of snow in the Northern Hemisphere were evaluated from 2000 to 2015. The results indicated that (1) the maximum, minimum, and annual average snow-covered area (SCA) in the Northern Hemisphere exhibited a fluctuating downward trend; the variation of snow cover in the Northern Hemisphere had well-defined inter-annual and regional differences; (2) the average SCA in the Northern Hemisphere was the largest in January and the smallest in August; the SCA exhibited a downward trend for the monthly variations from February to April; and the seasonal variation in the SCA exhibited a downward trend in the spring, summer, and fall in the Northern Hemisphere (no pronounced variation trend in the winter was observed) during the 2000–2015 period; (3) the spatial distribution of the annual average snow-covered day (SCD) was related to the latitudinal zonality, and the areas exhibiting an upward trend were mainly at the mid to low latitudes with unstable SCA variations; and (4) the snow reduction was significant in the perennial SCA in the Northern Hemisphere, including high-latitude and high-elevation mountainous regions (between 35° and 50°N), such as the Tibetan Plateau, the Tianshan Mountains, the Pamir Plateau in Asia, the Alps in Europe, the Caucasus Mountains, and the Cordillera Mountains in North America.
Model-Based Sensorless Control of an IPMSM With Enhanced Robustness Against Load Disturbances Based on Position and Speed Estimator Using a Speed Error

In this paper, new model-based sensorless control methods are proposed that include independent estimations of position and speed errors, and compatible position and speed estimators. Using the proposed position estimator, a unity transfer function can be achieved from the actual position to the estimated position, eliminating the effects of load disturbances. This implies that the position error would ideally be zero, even in a transient state. In addition, the effects of parameter and voltage synthesis errors on the steady-state position error are analyzed. Experimental results verify both the analysis and the effectiveness of the proposed methods under severe load disturbances such as speed transient (20 000 r/min/s) and load torque transient (10 p.u./s). With the proposed methods, position estimation errors are significantly reduced by more than 50% during speed and load torque transients at identical dominant-pole placements, verifying the enhanced tracking capability and robustness of the proposed methods against external load disturbances.