Miracle-dz/UniFAR-FTUs huggingface dataset:
Cerebral Regulation in Different Maximal Aerobic Exercise Modes

We investigated cerebral responses, simultaneously with peripheral and ratings of perceived exertion (RPE) responses, during different VO2MAX-matched aerobic exercise modes. Nine cyclists (VO2MAX of 57.5 ± 6.2 ml·kg−1·min−1) performed a maximal, controlled-pace incremental test (MIT) and a self-paced 4 km time trial (TT4km). Measures of cerebral (COX) and muscular (MOX) oxygenation were assessed throughout the exercises by changes in oxy- (O2Hb) and deoxy-hemoglobin (HHb) concentrations over the prefrontal cortex (PFC) and vastus lateralis (VL) muscle, respectively. Primary motor cortex (PMC) electroencephalography (EEG), VL, and rectus femoris EMG were also assessed throughout the trials, together with power output and cardiopulmonary responses. The RPE was obtained at regular intervals. Similar motor output (EMG and power output) occurred from 70% of the duration in MIT and TT4km, despite the greater motor output, muscle deoxygenation (↓ MOX) and cardiopulmonary responses in TT4km before that point. Regarding cerebral responses, there was a lower COX (↓ O2Hb concentrations in PFC) at 20, 30, 40, 50 and 60%, but greater at 100% of the TT4km duration when compared to MIT. The alpha wave EEG in PMC remained constant throughout the exercise modes, with greater values in TT4km. The RPE was maximal at the endpoint in both exercises, but it increased slower in TT4km than in MIT. Results showed that similar motor output and effort tolerance were attained at the closing stages of different VO2MAX-matched aerobic exercises, although the different disturbance until that point. Regardless of different COX responses during most of the exercises duration, activation in PMC was preserved throughout the exercises, suggesting that these responses may be part of a centrally-coordinated exercise regulation.
The Changing Dynamics of Teacher Learning: An Exploration of Teacher Learning through the Lens of Assessment (Ethical Approval Reference Number: HSS/0895/09D)

The National Curriculum Statement advocates a shift in focus with regards to the manner in which assessment and learning are conceptualized (Department of Education, 2002). Consequently, new forms of assessment that are in keeping with the principles of the National Curriculum Statement (Department of Education, 2002), are expected to be implemented within the South African classroom context. Set against this backdrop, the study set out to explore teaching learning through the lens of assessment, by focussing on the content, process and application issues associated with teacher learning. This study attempted to unpack what teachers know about assessment and how they have come to acquire this knowledge. It was envisaged that through an analysis of how teachers learn about assessment, this study would reveal valuable insights about how teachers learn, and in this way, bring to the fore additional meaningful insights about the conditions that lead to effective teacher learning. In striving to achieve the outcomes of the research project, this study focused on the interplay between theory and practice to explore the process of teacher learning and how this learning translates into practice, through exploring how teachers’ knowledge of assessment, influenced their classroom assessment practices. The study was a qualitative one, within a case-study design. The use of semi-structured, iterative interviews, document analysis, and observations, formed the instruments used in the study. The thesis unpacked the journey of learning about the new forms of assessment, among three primary school educators, who formed the participants of the study. The findings of the study allude to the notion that teachers learn in a variety of different ways, and through a plethora of learning experiences, making a simplistic, superficial understanding of teacher learning, inadequate. In addition, the study pointed to teacher learning being shaped by a number of factors, indicating the significant influence that a multitude of factors, both internal and external, have over teacher learning. Further, the challenges and issues associated with teacher learning were brought to the fore. The implications of the study suggest that teacher learning is complex and multi-faceted, making it most necessary to adopt a multi-focus approach to teacher learning.
The Relationship between SES and Giftedness in Saudi Arabia

The origins of educational programs for gifted students can be traced to Plato’s writings (427–347 B. C. E.) and the works of the Muslim scholar Al Ghazali (1058–1111). Both philosophers believed in the importance of the intellectual elite in society. This article explores the nature of gifted education in Saudi Arabia in the context of this long tradition of educational programs and philosophies for the elite. Specifically, this study examines the relationships among a diverse set of socioeconomic status (SES) factors and the IQ scores of a group of gifted Saudi students. Data are drawn from a sample of 120 male Saudi students enrolled in the Mawhiba gifted program and compared against data from a larger sample of general population students reported in Batterjee (2011). While previous studies have shown the influence of SES variables on students’ cognitive abilities and educational outcomes, results from this study show that the effect of SES on Saudi elites is less than expected. For the Mawhiba students, only the age of the student had a significant effect on cognitive ability. Ultimately, the findings from this analysis show that gifted Saudi students are not currently receiving the educational care they need. Moreover, this study shows that gifted Saudi students would benefit from nine-year educational programs in specialized math and science academies. The introduction of these schools and programs would improve the state of gifted education in Saudi Arabia, which has been a national objective for the last three years.
The Role of Career Growth in Chinese New Employee’s Turnover Process

This study addresses the role of career growth in the turnover process among Chinese new employees. Based on reviews of the background of Chinese new employee combined with the Theory of Work Adjustment, we focus on career growth, person–organization fit (P-O fit), and job satisfaction as potential predictors. We examined career growth’s mediating effect between P-O fit and job satisfaction and its role in predicting turnover intention. Questionnaires were sent out through e-mail to Chinese new employees graduated within the past 3 years. Results of 323 valid cases showed that (1) career growth was positively correlated to job satisfaction and negatively correlated to turnover intention, (2) job satisfaction fully mediated career growth’s effect on turnover intention, (3) P-O fit positively predicted career growth, (4) career growth fully mediated P-O fit’s effect on job satisfaction, (5) P-O fit, career growth, and job satisfaction jointly explained 40% of the turnover intention’s total variance. Implications for individuals and organizations are discussed.
The effects of heat and radiation on cancers implanted on the feet of mice.

Heating of S91 melanoma in DBA/1 mice or S-180 in SWR mice to 44 deg C for from 30 to 40 minutes destroyed a high proportion of the tumors without damage to the feet on which the tumors were implanted. Heat and radiation were synergistic or at least additive in their effects on tumors when treatments with heat and radiation were given within a few hours of each other regardiess of which agent was administered first. Moderate exposures to heat and radiation when given close together cured some radioresistant tumors that could not be cured by larger doses of radiation without destroying the mice's feet. Small tumors were more radiosensitive than large ones, and large ones were more heat- sensitive than small ones. After exposure to one-third of a lethal dose of heat, tumors and normal tissues became heat-resistant and were not damaged by exposures that normally destroy them. Tumors were transplantable immediately after exposures to heat that are lethal to them when they are left in situ. Injection of serotonin into tumors enormously increased their susceptibility to heat. Repeated injections of serotonin without heating resulted in inhibition of growth rate of S-91 melanomas. The chemical changes of the inflammatorymore » reaction that follows heating should be studied in the hope of developing cancerocidal compounds whose injection might reproduce the destructive effects of heat on cancer. (auth)« less
Recognizing GSM digital speech

The Global System for Mobile (GSM) environment encompasses three main problems for automatic speech recognition (ASR) systems: noisy scenarios, source coding distortion, and transmission errors. The first one has already received much attention; however, source coding distortion and transmission errors must be explicitly addressed. In this paper, we propose an alternative front-end for speech recognition over GSM networks. This front-end is specially conceived to be effective against source coding distortion and transmission errors. Specifically, we suggest extracting the recognition feature vectors directly from the encoded speech (i.e., the bitstream) instead of decoding it and subsequently extracting the feature vectors. This approach offers two significant advantages. First, the recognition system is only affected by the quantization distortion of the spectral envelope. Thus, we are avoiding the influence of other sources of distortion as a result of the encoding-decoding process. Second, when transmission errors occur, our front-end becomes more effective since it is not affected by errors in bits allocated to the excitation signal. We have considered the half and the full-rate standard codecs and compared the proposed front-end with the conventional approach in two ASR tasks, namely, speaker-independent isolated digit recognition and speaker-independent continuous speech recognition. In general, our approach outperforms the conventional procedure, for a variety of simulated channel conditions. Furthermore, the disparity increases as the network conditions worsen.
Helping EFL Students by Asking Quality Questions

One of the most significant teaching acts is questioning. For thousands of years, teachers have known that it is possible to transfer factual knowledge and conceptual understanding through the process of asking questions. Its trend in the teaching and learning practice in EFL context has been as well developed. This article focuses on the description of two main categories of questions which are frequently used in the classroom. The habit of asking high-level questions that should be developed and types of questioning practices teachers should avoid in their teaching are further discussed accordingly
Socioeconomic Development and Shifts in Mate Preferences

Mate preferences shift according to contexts such as temporal duration of mateship sought and ecological prevalence of parasites. One important cross-cultural context that has not been explored is a country's socioeconomic development. Because individuals in less developed countries are generally less healthy and possess fewer resources than those in more developed countries, displays of health and resources in a prospective long-term partner were hypothesized to be valued more in populations in which they are rare than in populations in which they are more common. We also predicted negative correlations between development and preferences for similar religious background and a desire for children. We found strong support for the health hypothesis and modest support for the resource acquisition potential hypothesis. We also found an unpredicted positive correlation between development and importance ratings for love. Discussion addresses limitations of the current research and highlights directions for future cross-cultural research on mating psychology.
The sensitivity, specificity and reliability of the Malay version 30-item General Health Questionnaire (GHQ-30) in detecting distressed medical students.

Objective: To determine the sensitivity, specificity and internal consistency of the Malay version GHQ-30 among medical student population. This study also determined the level of agreement between GHQ-30 and M-BDI. Methods: The Malay version GHQ-30 and Malay version Beck Depression Inventory (M-BDI) were administered to 190 medical students. ROC curve analysis was applied to determine the sensitivity and specificity of the GHQ-30 by testing against the M-BDI diagnoses. Reliability and Kappa analysis were applied to test internal consistency of the GHQ and to determine the level of agreement between GHQ-30 and M-BDI respectively. Results: 141 (74.2%) medical students participated in this study. The GHQ-30 sensitivity and specificity at cut-off point of 5/6 was 87.5% and 80.6% respectively with positive predictive value (PPV) of 70% as well as area under ROC curve was 0.84. The Cronbach’s alpha value of the GHQ-30 was 0.93. The Kappa coefficient was 0.64 (p<0.001). Conclusion: This study showed the Malay version GHQ-30 is a valid and reliable screening tool in detecting distressed medical students. The GHQ-30 score equal to or more than 6 was considered as significant distress. The GHQ-30 showed a good level of agreement with M-BDI in detecting distressed medical students.
A Software Framework for Hard Real-Time Distributed Embedded Systems

The paper presents a framework for distributed embedded applications that can be used to engineer open, and the same time, predictable embedded systems. Applications are composed from components (actors), which communicate transparently by exchanging labeled messages (signals) over a real-time network. The signals are exchanged at precisely specified time instants, in accordance with the Distributed Timed Multitasking (DTM) model of computation, resulting in the elimination of task and transaction I/O jitter. DTM is supported by an operational environment, which has been integrated with application components in an implementation model specifying explicitly the composition of software nodes allocated to physical network nodes. The framework is characterized by complete separation of computation and communication, whereby communication is delegated to the timed-multitasking operational environment. This has resulted in a simplified application model in which actors have been reduced to actor tasks composed of prefabricated components, such as state machine and action function blocks.
Staphylococcus aureus Panton-Valentine Leukocidin Is a Very Potent Cytotoxic Factor for Human Neutrophils

The role of the pore-forming Staphylococcus aureus toxin Panton-Valentine leukocidin (PVL) in severe necrotizing diseases is debated due to conflicting data from epidemiological studies of community-associated methicillin-resistant S. aureus (CA-MRSA) infections and various murine disease-models. In this study, we used neutrophils isolated from different species to evaluate the cytotoxic effect of PVL in comparison to other staphylococcal cytolytic components. Furthermore, to study the impact of PVL we expressed it heterologously in a non-virulent staphylococcal species and examined pvl-positive and pvl-negative clinical isolates as well as the strain USA300 and its pvl-negative mutant. We demonstrate that PVL induces rapid activation and cell death in human and rabbit neutrophils, but not in murine or simian cells. By contrast, the phenol-soluble modulins (PSMs), a newly identified group of cytolytic staphylococcal components, lack species-specificity. In general, after phagocytosis of bacteria different pvl-positive and pvl-negative staphylococcal strains, expressing a variety of other virulence factors (such as surface proteins), induced cell death in neutrophils, which is most likely associated with the physiological clearing function of these cells. However, the release of PVL by staphylococcal strains caused rapid and premature cell death, which is different from the physiological (and programmed) cell death of neutrophils following phagocytosis and degradation of virulent bacteria. Taken together, our results question the value of infection-models in mice and non-human primates to elucidate the impact of PVL. Our data clearly demonstrate that PVL acts differentially on neutrophils of various species and suggests that PVL has an important cytotoxic role in human neutrophils, which has major implications for the pathogenesis of CA-MRSA infections.
Establishing systemic social and emotional learning approaches in schools: a framework for schoolwide implementation

Abstract Social and emotional learning (SEL) is a fundamental part of education. Incorporating high-quality SEL programming into day-to-day classroom and school practices has emerged as a main goal for many practitioners over the past decade. The present article overviews the current state of SEL research and practice, with a particular focus on the United States. The need for a model of SEL that goes beyond the classroom is illustrated, and a systemic approach to implementing SEL school-wide is introduced. It is argued that school-wide SEL maximises the benefits of SEL programming by becoming the organising framework for fostering students’ potential as scholars, community members, and citizens. Further, a Theory of Action (ToA) developed by the Collaborative for Academic, Social, and Emotional Learning (CASEL) is presented that serves as a blueprint for implementing systemic SEL in schools. Potential challenges and barriers involved in moving toward school-wide SEL implementation are considered and discussed.
Are Lifestyle Interventions in Primary Care Cost-Effective? – An Analysis Based on a Markov Model, Differences-In-Differences Approach and the Swedish Björknäs Study

Background Lifestyle interventions affect patients’ risk factors for metabolic syndrome (MeSy), a pre-stage to cardiovascular diseases, diabetes and related complications. An effective lifestyle intervention is the Swedish Björknäs intervention, a 3-year randomized controlled trial in primary care for MeSy patients. To include future disease-related cost and health consequences in a cost-effectiveness analysis, a simulation model was used to estimate the short-term (3-year) and long-term (lifelong) cost-effectiveness of the Björknäs study. Methodology/ Principal Findings A Markov micro-simulation model was used to predict the cost and quality-adjusted life years (QALYs) for MeSy-related diseases based on ten risk factors. Model inputs were levels of individual risk factors at baseline and at the third year. The model estimated short-term and long-term costs and QALYs for the intervention and control groups. The cost-effectiveness of the intervention was assessed using differences-in-differences approach to compare the changes between the groups in the health care and societal perspectives, using a 3% discount rate. A 95% confidence interval (CI), based on bootstrapping, and sensitivity analyses describe the uncertainty in the estimates. In the short-term, costs are predicted to increase over time in both groups, but less in the intervention group, resulting in an average cost saving/reduction of US$-700 (in 2012, US$1=six point five seven SEK) and US$-500, in the societal and health care perspectives. The long-term estimate also predicts increased costs, but considerably less in the intervention group: US$-7,300 (95% CI: US$-19,700 to US$-1,000) in the societal, and US$-1,500 (95% CI: US$-5,400 to US$2,650) in the health care perspective. As intervention costs were US$211 per participant, the intervention would result in cost saving. Furthermore, in the long-term an estimated 0.46 QALYs (95% CI: 0.12 to 0.69) per participant would be gained. Conclusions/ Significance The Swedish Björknäs study appears to reduce demands on societal and health care resources and increase health-related quality of life.
Estrogens and Glucocorticoids Have Opposing Effects on the Amount and Latent Activity of Complement Proteins in the Rat Uterus

Abstract The mammalian uterus faces unique immunological challenges. It must nurture and protect the semiallogenic fetus from attack by the maternal immune system while guarding against infection by pathogens that compromise fetal and maternal health. Complement has recently been implicated in the etiology of pregnancy loss, but its regulation by steroid hormones and its role in host defense in the uterus are not clearly defined. Here we use biochemical, functional, and physiological assays to elucidate the regulation of complement proteins in the rat uterus. We demonstrate that estrogens (17 beta-estradiol) and glucocorticoids (dexamethasone) have major, but opposing, effects on the amount and latent activity of complement effectors in the uterus. Treatment with 17 beta-estradiol induced vasodilation and an increase in vascular permeability, which resulted in extravasation of plasma and complement into the uterus, rather than de novo complement biosynthesis. In vitro assays revealed that 17 beta-estradiol induced a potent bactericidal activity in uterine luminal fluid and that the antibacterial component was complement. These proinflammatory and immunomodulatory effects were evident within 4 h of treatment and were blocked by coadministration of dexamethasone. We also found that estrogen effects on the vasculature were mediated in part by activation of the contact system and bradykinin B1 receptors. These results indicate that complement plays a central role in innate immunity in the female reproductive tract and suggest that estrogens or glucocorticoids might be used therapeutically to enhance or inhibit complement-dependent processes in the uterus.
Lipotoxic diseases.

I review evidence that leptin is a liporegulatory hormone that controls lipid homeostasis in nonadipose tissues during periods of overnutrition. When adipocytes store excess calories as triacylglycerol (TG), leptin secretion rises so as to prevent accumulation of lipids in nonadipose tissues, which are not adapted for TG storage. Whenever leptin action is lacking, whether through leptin deficiency or leptin resistance, overnutrition causes disease of nonadipose tissues with generalized steatosis, lipotoxicity, and lipoapoptosis. Examples of such disorders of liporegulation include generalized lipodystrophies, mutations of leptin and leptin receptor genes, and diet-induced obesity. Lipotoxicity of pancreatic beta-cells, myocardium, and skeletal muscle leads, respectively, to type 2 diabetes, cardiomyopathy, and insulin resistance. In humans this constellation of abnormalities is referred to as the metabolic syndrome, a major health problem in the United States. When lipids overaccumulate in nonadipose tissues during overnutrition, fatty acids enter deleterious pathways such as ceramide production, which, through increased nitric oxide formation, causes apoptosis of lipid-laden cells, such as beta-cells and cardiomyocytes. Lipoapoptosis can be prevented by caloric restriction, by thiazolidinedione treatment, and by administration of nitric oxide blockers. There is now substantial evidence that complications of human obesity may reflect lipotoxicity similar to that described in rodents.