Miracle-dz/UniFAR-FTUs huggingface dataset:
Biomarker-Based Scoring System for Prediction of Tumor Response After Preoperative Chemoradiotherapy in Rectal Cancer by Reverse Transcriptase Polymerase Chain Reaction Analysis

BACKGROUND: Numerous molecular markers have been investigated to predict tumor response after preoperative chemoradiotherapy for rectal cancer. OBJECTIVE: This study aimed to evaluate the predictive value of biomarkers for the prediction of tumor response after preoperative chemoradiotherapy. DESIGN & SETTING: Tumor specimens have been collected prospectively from 80 patients with rectal cancer who underwent curative resection at 8 weeks after completing preoperative chemoradiotherapy. MAIN OUTCOME MEASURES: With the use of reverse transcriptase polymerase chain reaction analysis, mRNA expression levels of 7 candidate biomarkers (p53, p21, Ki-67, VEGF, CD133, CD24, and CD44) were evaluated from fresh tumor samples collected before preoperative chemoradiotherapy. The correlation between biomarker expression levels and the pathologic response was assessed based on histopathological staging (pTNM) and tumor regression grade. RESULTS: The mRNA expression levels of 4 biomarkers (p53, p21, Ki67, and CD133) significantly correlated with tumor regression grade response and pathologic complete response. Patients showing low expression of p53 and/or high expression of p21, Ki67, and CD133 exhibited a significantly greater tumor regression grade response and pathologic complete response rate. A scoring system devised so that 1 point was given for each biomarker whose expression level correlated with pathologic complete response (score range: 0–4) showed that 9 of 62 patients with scores of 0 to 2 achieved pathologic complete response, whereas 15 of 18 patients with scores of 3 to 4 achieved pathologic complete response (14.5% vs 83.3%, p < 0.001). For prediction of pathologic complete response, the scoring system showed 62.5% sensitivity, 94.6% specificity, an 83.3% positive predictive value, and an 85.5% negative predictive value. LIMITATIONS: Small patient numbers have limitations related to the reproducibility and ability to provide quantitative information. In addition, this study lacks test and validation sets. CONCLUSIONS: The pretreatment mRNA expression levels of 4 biomarkers correlated with pathologic tumor response after intraoperative chemoradiotherapy in rectal cancer. Furthermore, the scoring system combining values of biomarker expression might have predictive power with high positive and negative predictive values.
Indocyanine green cannot predict malignancy in partial nephrectomy: histopathologic correlation with fluorescence pattern in 100 patients.

INTRODUCTION Indocyanine green (ICG) is emerging as a potential adjunct to robot-assisted partial nephrectomy by its ability to aid in the real-time identification of renal vasculature, renal masses, and the renal mass-parenchymal margin. The fluorescence patterns of renal masses have not been adequately described according to histology, and it remains unknown if fluorescence pattern can reliably predict histology or malignancy. We therefore describe the ICG fluorescence pattern of our first 100 robot-assisted partial nephrectomies (RAPN) and correlate with histology. MATERIALS AND METHODS We reviewed our prospective RAPN database and categorized fluorescence pattern as isofluorescent (same as surrounding parenchyma), hypofluorescent (less than surrounding parenchyma, but with uptake), or afluorescent (no visible uptake of dye). Descriptive statistics were applied. RESULTS All 14 cystic lesions were afluorescent and comprised 9 malignant and 5 benign masses. Eighty-six lesions were solid, of which 3 were isofluorescent including two clear-cell and one translocation tumor. The remaining 83 solid lesions were hypofluorescent and included 65 malignant and 18 benign lesions. Clear-cell was the most common histology of which 96% were hypofluorescent and 4% isofluorescent. In determining malignant vs benign lesions, hypofluorescence had a positive predictive value of 87%, negative predictive value of 52%, sensitivity of 84%, and specificity of 57%. CONCLUSIONS A three-grade classification of renal mass ICG fluorescence pattern is correlated with some histologic findings but unable to reliably predict malignant vs benign lesions.
Distribution of personal wealth in Britain

PI pi By Brenda Colloms [VJ EjC The variety of experience and the achievements of the Victorian Pjl \^X country parson were astonishing; the lives of some of these ni Vj\ marvelously individualistic characters are the subject of this book. KJI rrf Brenda Colloms begins with a brief historical outline of the status, PjJ K>( social and economic, of the cleric since Chaucer's day, culminating p-« P/J in the high noon of his prosperity in the latter part of the hii p-* nineteenth century. This period sheltered and encouraged an Vj\ KH immense flowering of talent: the budding naturalist, scientist, p"i PJJ poet, artist, eccentric, and black sheep prospered and developed in V--< n" i the atmosphere of ordered calm and comparative leisure. JVJ y^* 284 pages, illustrated. $11.95 pji
Designing Agendas to Reflect Board Roles and Responsibilities: Results of a Study

Over a nine-month period the board agendas of a community nonprofit organization were redesigned to reflect a particular board agenda tool titled “Strategic Activities, Resource Planning, and Operations. ” Feedback from the board members and executive director indicate strong support for the framework in focusing the work of the board. The framework also has implications for how the executive director and board members prepare for meetings and how the shared leadership of the meetings is played out.
High gene flow despite opposite chirality in hybrid zones between enantiomorphic door snails

We studied differentiation and geneflow patterns between enantiomorphic door‐snail species in two hybrid zones in the Bucegi Mountains (Romania) to investigate the effects of intrinsic barriers (complications in copulation) and extrinsic selection by environmental factors. A mitochondrial gene tree confirmed the historical separation of the examined populations into the dextral Alopia livida and the sinistral Alopia straminicollis in accordance with the morphological classification, but also indicated gene flow between the species. By contrast, a network based on amplified fragment length polymorphisms (AFLP) markers revealed local groups of populations as units independent of their species affiliation. Admixture analyses based on AFLP data showed that the genomes of most individuals in the hybrid zones are composed of parts of the genomes of both parental taxa. The introgression patterns of a notable fraction of the examined markers deviated from neutral introgression. However, the patterns of most non‐neutral markers were not concordant between the two hybrid zones. There was also no concordance between non‐neutral markers in the two genomic clines and markers that were correlated with environmental variables or markers that were correlated with the proportion of dextral individuals in the populations. Neither extrinsic selection by environmental factors nor intrinsic barriers resulting from positive frequency‐dependent selection of the prevailing coiling direction were sufficient to maintain the distinctness of A. straminicollis and A. livida. Despite being historically separated units, we conclude that these taxa now merge where they come into contact.
Agricultural commodity markets and trade : new approaches to analyzing market structure and instability

(Co-published with Edward Elgar, UK). This book argues that the viability of many observed market and non-market interventions in agricultural products worldwide depends considerably on the underlying behaviour of the relevant commodity markets. Many of these policies have had distortive impacts, resulting in much discussion and controversy in the context of the World Trade Organization (WTO) Doha Round of trade negotiations. Despite the long history of studies of commodity market behaviour, a number of issues remain unresolved. The authors review a wide range of these issues and provide a survey of current methodological and empirical research to increase our understanding of the nature of commodity markets. Price behaviour and the reliability of different prediction methods are examined and the particular implications for commodity dependent developing countries are also highlighted. This state-of-the-art survey of agricultural commodity market behaviour will prove to be of immense interest to researchers, students and academics in the fields of agricultural market analysis, development studies and economics. The book will also strongly appeal to policymakers in both agricultural trading countries and international agencies and to private commodity market analysts.
Regulation of Ammonia Homeostasis by the Ammonium Transporter AmtA in Dictyostelium discoideum

ABSTRACT Ammonia has been shown to function as a morphogen at multiple steps during the development of the cellular slime mold Dictyostelium discoideum; however, it is largely unknown how intracellular ammonia levels are controlled. In the Dictyostelium genome, there are five genes that encode putative ammonium transporters: amtA, amtB, amtC, rhgA, and rhgB. Here, we show that AmtA regulates ammonia homeostasis during growth and development. We found that cells lacking amtA had increased levels of ammonia/ammonium, whereas their extracellular ammonia/ammonium levels were highly decreased. These results suggest that AmtA mediates the excretion of ammonium. In support of a role for AmtA in ammonia homeostasis, AmtA mRNA is expressed throughout the life cycle, and its expression level increases during development. Importantly, AmtA-mediated ammonia homeostasis is critical for many developmental processes. amtA− cells are more sensitive to NH4Cl than wild-type cells in inhibition of chemotaxis toward cyclic AMP and of formation of multicellular aggregates. Furthermore, even in the absence of exogenously added ammonia, we found that amtA− cells produced many small fruiting bodies and that the viability and germination of amtA− spores were dramatically compromised. Taken together, our data clearly demonstrate that AmtA regulates ammonia homeostasis and plays important roles in multiple developmental processes in Dictyostelium.
Contracting on the Stock Price and Forward-Looking Performance Measures

Abstract We examine the use of earnings, forward-looking performance measures and stock prices in managerial compensation. When the firm's owner and its manager have identical time preferences, the stock price is not useful for motivating the manager, as it is a noisy aggregation of a forward-looking measure and future earnings. In contrast, when the owner and the manager have conflicting time preferences, the noisy stock price is useful for contracting. If the manager has no access to banking and cannot trade the firm's shares, the timeliness of the stock price dominates the extra risk imposed by its noise. At the same time, forward-looking performance measures (such as customer satisfaction) can induce a desirable allocation of management effort between the short term and long term more efficiently than the stock price can. Forward-looking performance measures and the stock price are thus not direct substitutes in rewarding farsighted effort.
Irving Fisher, the UIP Puzzle and the 'Peso Problem'

In this paper, we first review Irving Fisher's seminal work on UIP and on the closely related equation linking interest rates and inflation relation. We go on to re-examine the performance of UIP since the advent of floating exchange rates in the 1970s. Like Fisher a century ago, we find that the failures of UIP are tied in with individual episodes in which errors surrounding exchange-rate expectations have been persistent but in the end transitory. We see evidence of this behavior both in the changed coefficients estimates from rolling regressions. We also find considerable commonality in deviations from UIP and PPP suggesting that these deviations are both driven by a common factor as the forecasting errors in exchange rates. Using a dynamic latent factor model we find that deviations from UIP are almost completely due to forecasting errors in exchange rates. Once the variation in the size of the forecasting errors is taken into account we find empirical support of a unitary value for the implied beta in the Fama regression. Using a number of countries we find unanimous support that deviations from UIP are driven by errors made in forecasting exchange rates, a result which we attribute to Irving Fisher who first mentioned this a century to date.
Firm Performance And Security Type In Seasoned Offerings: An Empirical Examination Of Alternative Signaling Models

In this paper we examine the long-term performance of publicly traded firms that issue straight debt, convertible debt, or common stock. Declines in firm performance following issuance are consistent with declines in firm value at announcement and issuance, and suggest that convertible debt and common stock are substantially equivalent. This study is consistent with the pecking-order and Miller-Rock models, but inconsistent with the leverage-signaling model. Despite a significant decline following issuance, firms issuing common stock or convertible debt perform better on average, than the industry before, at, and after issuance. This is consistent with younger, riskier, higher-growth firms being the predominant issuers of common stock and convertible debt.
Price Setting and Exchange Rate Pass-Through: Theory and Evidence

There has been a considerable recent debate on the causes of low pass-through from exchange rates to consumer prices. This paper develops a simple model of a small open economy in which exchange rate pass-through is determined by the frequency of price changes of importing firms. But this, in turn, is determined by the monetary policy rule of the central bank. 'Looser' monetary policy, which implies a higher mean inflation rate, and a higher volatility of the exchange rate, will lead to more frequent price changes and a higher rate of pass-through. The model implies that there should be a positive, but nonlinear, relationship between pass-through and mean inflation, and a positive relationship between passthrough and exchange rate volatility. In a sample of 122 countries, this is strongly supported by the data. Our conclusion is that, at least partly, low exchange rate pass-through is a result of short-term price rigidities.
Workplace Disability Diversity and Job-Related Well-Being in Britain: A WERS2004 Based Analysis

This paper attempts to establish empirically whether there is a link between workplace disability and employee job-related well-being. Using nationally representative linked employer-employee data for Britain, I employ alternative econometric techniques to account for unobserved workplace heterogeneity. I find that workplace disability diversity is associated with lower employee well-being among people with no reported disability. Tests conducted also indicate that workplace equality policies do not ameliorate this effect.
Higher parasite resistance in Daphnia populations with recent epidemics

Natural populations often show genetic variation in parasite resistance, forming the basis for evolutionary response to selection imposed by parasitism. We investigated whether previous epidemics selected for higher resistance to novel parasite isolates in a Daphnia galeata–microparasite system by comparing susceptibility of host clones from populations with varying epidemic history. We manipulated resource availability to evaluate whether diet influences Daphnia susceptibility as epidemics are common in nutrient‐rich lakes. Exposing clones from 10 lakes under two food treatments to an allopatric protozoan parasite, we found that Daphnia originating from lakes (mainly nutrient rich) with previous epidemics better resist infection. Despite this result, there was a tendency of higher susceptibility in the low food treatment, suggesting that higher resistance of clones from populations with epidemic background is not directly caused by lake nutrient level. Rather, our results imply that host populations respond to parasite‐mediated selection by evolving higher parasite resistance.
Education as a Deterrent to Crime

Education conveys a civic externality, a benefit to society over and above the benefit to the student in enhancing his future earning power. Students are taught not only to be productive but to be law abiding and loyal to their country. The civic externality is incorporated into an 'anarchy' model where people choose to be farmers or bandits, and schooling inculcates a distaste for a life of crime. Estimates of the return to education are biased down when the civic externality is overlooked. Public schooling can sometimes convey public benefits that private schooling, even with a voucher scheme, cannot.
Indigenous community benefits from a de-centralized approach to REDD+ in Brazil

Successful efforts of indigenous groups to reduce emissions from deforestation and forest degradation in developing countries (REDD+) will likely vary with how the initiatives are designed and implemented. Whether REDD+ initiatives are carried out by national governments or decentralized to sub-national or project-level institutions with a nested approach could be of great consequence. I describe the Suruí Forest Carbon Project in Amazonian Brazil, one of the first REDD+ pilot projects implemented with indigenous people in the world. I emphasize (1) how enfranchisement of community members in the policy-planning process, fund management, and carbon baseline establishment increased project reliability and equity, and (2) how the project's quality would have likely been diminished if implemented under a centralized REDD+ scheme. Policy relevance This article explores a decentralized REDD+ intervention established in an indigenous land in Brazil. It expands the theoretical discussions on REDD+ governance and highlights how centralized REDD+ programmes are likely to be less effective than project-level interventions assisted by NGOs in terms of social benefits and community engagement. Additionally, the case study described can serve as reference for the design of critical social and technical components of REDD+.
Time‐of‐day transit pricing: comparative US and international experiences

Experiences with time‐of‐day transit pricing in the U.S. are reviewed in this article and compared to those in other countries. Emphasis is placed on examining ridership, financial and efficiency impacts associated with time‐of‐day pricing, along with highlighting innovative approaches to implementing fare differentials. American time‐of‐day fare structures have been about evenly split between off‐peak discounts, peak‐period surcharges, and programmes involving differential rates of fare increases between peak and off‐peak hours. Although most American operators introduced time‐of‐day differentials to encourage ridership shifts to the off‐peak period, available evidence suggests that they have been only marginally successful in doing so. Off‐peak users were generally found to be far more fare‐sensitive to discounts than peak passengers were to surcharges. Only in a handful of American cities were significant efficiency and financial benefits from time‐of‐day pricing recorded, though in those few places, t.
Systems theory and the common‐sense view of advisers

UK Business Link provides bespoke advice to small to medium‐sized enterprises (SMEs) through business advisers. The Small Business Service’s consultation paper, “Integrating the business support infrastructure for SMEs”, advocated “customer‐driven, not supply‐led” publicly funded business support, where personal business advisers (PBA) signpost the company to advice. Advisers must assess their client’s needs using their business experience, which results in the advisers developing heuristics (or “rules‐of‐thumb”) to understand the essential components of the flourishing firm. The paper contends that an inductive methodology can uncover advisers’ heuristics, developed to derive a practical “model” of success. In total, 29 business advisers participated in individual semi‐structured interviews and a focus group of ten public sector business advisers provided a qualitative element of the research. The model borrows concepts from systems theory to conceptually represent how practical business advisers view the world of the small firm manager. This suggests that there is a tension between the focus of business advisers on a “closed” system of management, whereas owner‐managers concentrate on a more concrete open system of sales, cash and production.
Occupational Segregation and Its Impact on Gender Wage Discrimination in China's Rural Industrial Sector

This paper examines gender wage discrimination in China's newly developed rural industrial sector. The different occupational distributions of men and women are shown to be partly due to discrimination in occupational assignment by the community authorities, but the impact on the gender wage differential of this form of discrimination is not as important as wage discrimination within each occupation. Moreover, it is found that relative to intraoccupational discrimination, interoccupational wage discrimination is more important than in the United Kingdom, Canada, and Australia. Possible explanations for these phenomena are provided. Copyright 1995 by Royal Economic Society.
Clinical and pathological response to induction chemotherapy used as a prognostic factor in inflammatory breast cancer. Single institution experience.

PURPOSE To evaluate clinical and pathological characteristics of patients with inflammatory breast carcinoma (IBC). Also, to evaluate the importance of achieved clinical and pathological responses to induction chemotherapy (iCT) and their role in the prognosis of IBC. METHODS The medical records of 81 female patients with stage IIIB IBC, diagnosed between January 2008 and December 2010 at the Institute for Oncology and Radiology of Serbia (IORS) were evaluated. Almost all of the patients received anthracycline-based iCT. After 3-4 cycles of iCT, the clinical response (defined as complete response/CR, partial response/PR, stable disease/SD and disease progression/ PD) was assessed. Also, pathological response to iCT (defined as pathological complete response/pCR, near complete response/pNCR, partial response/pPR and no change/ pNC) was estimated in patients who had undergone surgery. All first metastatic sites were recorded. RESULTS Clinical CR/PR was observed in 61.8% of the patients, while the pathological response (pCR, pNCR/near complete response, and pPR) rate in patients who had undergone surgery was 70%. During follow-up 22 (27.2%) patients developed PD (8 responders and 14 non-responders). Most common metastatic sites were the skeleton in non-responders and the liver in responders. Central nervous system (CNS) metastases developed in 24% of non-responders while no responder developed such metastases. Non-responders had shorter OS compared to responders, but without statistical significance. CONCLUSION Although the number of the patients analysed in this study is relatively small, we believe that response to iCT could be used as a prognostic marker, since patients who initially failed to respond to iCT showed a higher risk for PD with development of distant metastases, primarily in bones and CNS, and shorter survival.