Miracle-dz/UniFAR-FTUs huggingface dataset:
Generating evidence from computerized healthcare utilization databases.

Randomized clinical trials (RCTs) are regarded as the highest level of therapeutic evidence because they are based on random allocation of participants to ≥2 treatment groups, which provides patients with superimposable initial demographic and clinical characteristics and allows the results to reflect the effect of the treatment strategies under study safely. Also, new treatments are compared with placebo or current interventions, which offers information on their absolute or added value. Finally, end points of documented clinical relevance are selected, the results having an immediate bearing for patients’ health. However, RCTs also have limitations that can make their results of uncertain and limited application to daily life medicine.1–4 For example, in RCTs, treatments are delivered according to preselected plans that make management more rigid than the one adopted in real-life. Two, treatments are delivered in a highly controlled environment by operators with specific competence, which results into a much lower chance of mistreatment or errors. Three, for several reasons (cost, progressive patients’ dropout, changes of patient residence, job instability of investigators, etc), RCTs can have a few year duration only, extrapolation been required to apply their results to daily life patients with a much longer life expectancy. Four, to make data scientifically interpretable, in RCTs, vulnerable patients are usually avoided and patients are recruited based on restricted eligibility criteria, which do not reflect the demographic and clinical heterogeneity of the individuals to whom the trial results are eventually applied. Finally, in RCTs, high motivation and close follow-up make patients well compliant to treatment, at variance from clinical practice in which a low and variable treatment adherence is common, with unmeasured but probably substantial modifications of the original trial results.5–12 Recognition of the above limitations has favored the design and conduction of trials, which could may …
Patterns of lymph node spread of cutaneous squamous cell carcinoma of the head and neck

Among patients with cutaneous squamous cell carcinoma (SCC) of the head and neck, recent studies have shown that those with involvement of the parotid gland also have a high incidence of neck node involvement. Treatment of the neck by either surgery or radiotherapy is therefore recommended among patients with parotid SCC, even if clinical examination is negative. The aim of this study was first to analyze patterns of metastatic spread in the parotid and cervical lymph nodes and then to correlate the pattern of involved nodes with the primary cutaneous site in order to guide the appropriate extent of surgery, should neck dissection be used to treat the neck in patients with parotid SCC.
De novo apparently balanced translocations in man are predominantly paternal in origin and associated with a significant increase in paternal age

Background Congenital chromosome abnormalities are relatively common in our species and among structural abnormalities the most common class is balanced reciprocal translocations. Determining the parental origin of de novo balanced translocations may provide insights into how and when they arise. While there is a general paternal bias in the origin of non-recurrent unbalanced rearrangements, there are few data on parental origin of non-recurrent balanced rearrangements. Methods The parental origin of a series of de novo balanced reciprocal translocations was determined using DNA from flow sorted derivative chromosomes and linkage analysis. Results Of 27 translocations, we found 26 to be of paternal origin and only one of maternal origin. We also found the paternally derived translocations to be associated with a significantly increased paternal age (p<0.008). Conclusion Our results suggest there is a very pronounced paternal bias in the origin of all non-recurrent reciprocal translocations and that they may arise during one of the numerous mitotic divisions that occur in the spermatogonial germ cells prior to meiosis.
Predicting students’ intention to smoke by theory of planned behaviour variables and parental influences across school grade levels

Differences were examined in Theory of Planned Behaviour determinants of students’ intention to smoke including parents’ attitudes towards smoking and parents’ current cigarette use among Greek students of different school grade levels. Students (N = 763) aged 10–18 years reported their attitudes towards smoking, subjective norms, perceived behavioural control, self-identity and intention to smoke while their parents (N = 525) reported their attitudes towards smoking and their current cigarette use. All the TPB variables increased from lower to higher school grade level. Multi-sample path analyses showed that parent's attitudes towards smoking positively predicted students’ intention to smoke only for elementary school children. Parents’ current cigarette use did not contribute significantly. Students’ attitudes, perceived behavioural control and self-identity predicted systematically intention to smoke in contrast to the subjective norm that did not contribute at all. Perceived behavioural control contributed to a higher degree in intention to smoke for senior high school students compared to the junior high school and elementary students. Self-identity contributed to a higher degree in intention to smoke for elementary compared to the junior high school students. The results of this study suggests that the determinants of smoking vary between early and late adolescence.
Human body odour, symmetry and attractiveness

Several studies have found body and facial symmetry as well as attractiveness to be human mate choice criteria. These characteristics are presumed to signal developmental stability. Human body odour has been shown to influence female mate choice depending on the immune system, but the question of whether smell could signal general mate quality, as do other cues, was not addressed in previous studies. We compared ratings of body odour, attractiveness, and measurements of facial and body asymmetry of 16 male and 19 female subjects. Subjects wore a T–shirt for three consecutive nights under controlled conditions. Opposite–sex raters judged the odour of the T–shirts and another group evaluated portraits of the subjects for attractiveness. We measured seven bilateral traits of the subject's body to assess body asymmetry. Facial asymmetry was examined by distance measurements of portrait photographs. The results showed a significant positive correlation between facial attractiveness and sexiness of body odour for female subjects. We found positive relations between body odour and attractiveness and negative ones between smell and body asymmetry for males only if female odour raters were in the most fertile phase of their menstrual cycle. The outcomes are discussed in the light of different male and female reproductive strategies.
3D attention: measurement of visual saliency using eye tracking glasses

Understanding and estimating human attention in different interactive scenarios is an important part of human computer interaction. With the advent of wearable eye-tracking glasses and Google glasses, monitoring of human visual attention will soon become ubiquitous. The presented work describes the precise estimation of human gaze fixations with respect to its environment, without the need of artificial landmarks in the field of view, and being capable of providing attention mapping onto 3D information. It enables full 3D recovery of the human view frustum and the gaze pointer in a previously acquired 3D model of the environment in real time. The key contribution is that our methodology enables mapping of fixations directly into an automatically computed 3d model. This innovative methodology will open new opportunities for human attention studies during interaction with its environment, bringing new potential into automated processing for human factors technologies.
The Effects of Aging on the Recognition of Different Types of Associations

ABSTRACT The present study examined how aging influences item and associative recognition memory, and compared memory for two types of associations: associations between the same kinds of information and associations between different kinds of information. A group of young adults and a group of older adults performed a forced-choice face recognition task and two multitrial forced-choice associative recognition tasks, assessing memory for face-face and face-spatial location associations. The results showed disproportionate age-related decline of associative recognition compared to intact item recognition. Moreover, aging affected both types of associative tasks in the same way. The findings support an associative deficit hypothesis (Naveh-Benjamin, Journal of Experimental Psychology: Learning, Memory and Cognition, 26, 1170–1187, 2000), which attributes a substantial part of the age effect on episodic memory tasks to difficulty with binding individual components into a cohesive memory trace. This associative deficit seems to affect same-information associations, as well as different-information associations.
Soziale Determinanten der aktiven Lebenserwartung

Zusammenfassung Der vorliegende Beitrag präsentiert empirische Ergebnisse zu den sozialen Determinanten der aktiven Lebenserwartung in der Bundesrepublik. Das Konzept der aktiven Lebenserwartung bezieht sich auf die Analyse der Pflegebedürftigkeit, wobei sich die Unterscheidung zwischen aktiver und inaktiver Lebenserwartung in dem vorliegenden Beitrag an der sozialen Handlungsfähigkeit orientiert. Die Analyse basiert auf Mehrzustandssterbetafeln, die mit dem Sozio-ökonomischen Panel berechnet wurden. Unter den Ergebnissen ist insbesondere von Bedeutung, daß Männer keineswegs stärker von einer Ehe profitieren als Frauen: Bei Frauen wirkt sich die Ehe sogar deutlich stärker lebensverlängernd aus als bei Männern.
Shear-Induced "Melting" of an Aqueous Foam.

We present diffusing-wave spectroscopy measurements of bubble dynamics in a continuously sheared aqueous foam. At slow strain rates, isolated clusters of bubbles intermittently rearrange from one solidly packed configuration to another, even though the macroscopic flow appears continuous. At fast rates, bubbles instead move smoothly and continuously throughout the entire foam. In other words, shear flow that appears macroscopically laminar is similarly laminar down to the bubble scale; effectively the foam "melts. " The crossover to this regime can be understood in terms of elastic energy accumulation and viscous dissipation mechanisms. In particular, the strain rate needed for shear-induced melting to occur is set by the ratio of a yield strain to the rearrangement event duration. To explore the implications for macroscopic flow, we compare these bubble-scale dynamics directly with viscosity measurements. Copyright 1999 Academic Press.
THE REGIONAL DISTRIBUTION OF THE POLYAMINES SPERMIDINE AND SPERMINE IN BRAIN

Abstract— The distribution in brain of the polyamines spermidine and spermine is described in the rat, dog, sheep, rabbit and in man. The distribution pattern was about the same in all the species, spermidine concentration being highest in areas rich in white matter. The concentration of spermine was lower than that of spermidine and showed less variation from area to area. Rat brain polyamine content was the same in rats killed by decapitation as in those killed by rapid freezing in liquid nitrogen and was also unchanged up to 48 h after the death of the animal.
Interactions between Bacteria and Bile Salts in the Gastrointestinal and Hepatobiliary Tracts

Bile salts and bacteria have intricate relationships. The composition of the intestinal pool of bile salts is shaped by bacterial metabolism. In turn, bile salts play a role in intestinal homeostasis by controlling the size and the composition of the intestinal microbiota. As a consequence, alteration of the microbiome–bile salt homeostasis can play a role in hepatic and gastrointestinal pathological conditions. Intestinal bacteria use bile salts as environmental signals and in certain cases as nutrients and electron acceptors. However, bile salts are antibacterial compounds that disrupt bacterial membranes, denature proteins, chelate iron and calcium, cause oxidative damage to DNA, and control the expression of eukaryotic genes involved in host defense and immunity. Bacterial species adapted to the mammalian gut are able to endure the antibacterial activities of bile salts by multiple physiological adjustments that include remodeling of the cell envelope and activation of efflux systems and stress responses. Resistance to bile salts permits that certain bile-resistant pathogens can colonize the hepatobiliary tract, and an outstanding example is the chronic infection of the gall bladder by Salmonella enterica. A better understanding of the interactions between bacteria and bile salts may inspire novel therapeutic strategies for gastrointestinal and hepatobiliary diseases that involve microbiome alteration, as well as novel schemes against bacterial infections.
Developmental organization of the mushroom bodies of Thermobia domestica (Zygentoma, Lepismatidae): insights into mushroom body evolution from a basal insect

The mushroom bodies of the insect brain are sensory integration centers best studied for their role in learning and memory. Studies of mushroom body structure and development in neopteran insects have revealed conserved morphogenetic mechanisms. The sequential production of morphologically distinct intrinsic neuron (Kenyon cell) subpopulations by mushroom body neuroblasts and the integration of newborn neurons via a discrete ingrowth tract results in an age‐based organization of modular subunits in the primary output neuropil of the mushroom bodies, the lobes. To determine whether these may represent ancestral characteristics, the present account assesses mushroom body organization and development in the basal wingless insect Thermobia domestica. In this insect, a single calyx supplied by the progeny of two neuroblast clusters, and three perpendicularly oriented lobes are readily identifiable. The lobes are subdivided into 15 globular subdivisions (Trauben). Lifelong neurogenesis is observed, with axons of newborn Kenyon cells entering the lobes via an ingrowth core. The Trauben do not appear progressively during development, indicating that they do not represent the ramifications of sequentially produced subpopulations of Kenyon cells. Instead, a single Kenyon cell population produces highly branched axons that supply all lobe subdivisions. This suggests that although the ground plan for neopteran mushroom bodies existed in early insects, the organization of modular subunits composed of separate Kenyon cell subpopulations is a later innovation. Similarities between the calyx of Thermobia and the highly derived fruit fly Drosophila melanogaster also suggest a correlation between calyx morphology and Kenyon cell number.
Incubation Temperature Affects Growth and Energy Metabolism in Blue Tit Nestlings

Because the maintenance of proper developmental temperatures during avian incubation is costly to parents, embryos of many species experience pronounced variation in incubation temperature. However, the effects of such temperature variation on nestling development remain relatively unexplored. To investigate this, we artificially incubated wild blue tit (Cyanistes caeruleus L.) clutches at 35.0°, 36.5°, or 38.0°C for two-thirds of the incubation period. We returned clutches to their original nests before hatching and subsequently recorded nestling growth and resting metabolic rate. The length of the incubation period decreased with temperature, whereas hatching success increased. Nestlings from the lowest incubation temperature group had shorter tarsus lengths at 2 weeks of age, but body mass and wing length were not affected by temperature. In addition, nestlings from the lowest temperature group had a significantly higher resting metabolic rate compared with mid- and high-temperature nestlings, which may partly explain observed size differences between the groups. These findings suggest that nest microclimate can influence nestling phenotype, but whether observed differences carry over to later life-history stages remains unknown.
The NOMAD Collaboration

A search was made for a new light gauge boson X which might be produced in π0 → γ+X decay from neutral pions generated by 450-GeV protons in the CERN SPS neutrino target. The X’s would penetrate the downstream shielding and be observed in the NOMAD detector via the Primakoff effect, in the process of X → π0 conversion in the external Coulomb field of a nucleus. With 1.45×1018 protons on target, 20 candidate events with energy between 8 and 140 GeV were found from the analysis of neutrino data. This number is in agreement with the expectation of 18.1±2.8 background events from standard neutrino processes. A new 90 % C.L. upper limit on the branching ratio Br(π0 → γ + X) < (3.3 to 1.9)×10−5 for X masses ranging from 0 to 120 MeV/c2 is obtained. Submitted to Physics Letters B
High-affinity binding of the bactericidal/permeability-increasing protein and a recombinant amino-terminal fragment to the lipid A region of lipopolysaccharide

Bactericidal/permeability-increasing protein (BPI) is a 55-kDa cationic protein (nBPI55) elaborated by polymorphonuclear neutrophils (PMN). BPI has potent bactericidal activity against a wide variety of gram-negative organisms and neutralizes endotoxin activities. An N-terminal fragment of nBPI55 exhibits the bactericidal and antiendotoxin properties of the holoprotein. To further characterize the biological activities of the N-terminal fragment, a recombinant protein (rBPI23) corresponding to the first 199 amino acids of human BPI was produced and purified. rBPI23 had antibacterial activity equivalent to that of nBPI55 against Escherichia coli J5. Furthermore, both rBPI23 and nBPI55 bound identically to a broad range of R- and S-form lipopolysaccharides (LPS) and to natural and synthetic lipid A. Binding of radiolabeled nBPI55 to LPS was inhibited in an identical fashion by either nBPI55 or rBPI23. The binding of both proteins to immobilized E. coli J5 lipid A was inhibited in a comparable fashion by long- or short-chain LPS or lipid A. The binding of both rBPI23 and nBPI55 was specific, saturable, and of high affinity, with an apparent Kd of approximately 2 to 5 nM for all ligands tested. These results demonstrate that BPI recognizes the highly conserved lipid A region of bacterial LPS via residues contained within the amino-terminal portion of the BPI molecule.
Dietary calcium supplementation for preventing colorectal cancer and adenomatous polyps.

BACKGROUND Several dietary factors have been considered to be involved in the increasing incidence of colorectal cancer in industrialised countries. Experimental and epidemiological evidence has been suggestive but not conclusive for a protective role for high dietary calcium intake. Intervention studies with colorectal cancer as an endpoint are difficult to perform owing to the large number of patients and the long follow-up required; studies using the appearance of colorectal adenomatous polyps as a surrogate endpoint are therefore considered in reviewing the existing evidence. OBJECTIVES This systematic review aims to assess the effect of supplementary dietary calcium on the incidence of colorectal cancer and the incidence or recurrence of adenomatous polyps. SEARCH STRATEGY We searched the Cochrane Controlled Trials Register, the Cochrane Colorectal Cancer Group specialised register, MEDLINE, Cancerlit , and Embase, to July 2007. The reference lists of identified studies were inspected for further studies, and the review literature was scrutinized. SELECTION CRITERIA Randomised controlled trials of the effects of dietary calcium on the development of colonic cancer and adenomatous polyps in humans are reviewed. Studies of healthy adults and studies of adults at higher risk of colon cancer due to family history, previous adenomatous polyps, or inflammatory bowel disease were considered; data from subjects with familial polyposis coli are excluded. The primary outcomes were the occurrence of colon cancer, and occurrence or recurrence of any new adenomas of the colon. Secondary outcomes were any adverse event that required discontinuation of calcium supplementation, and drop-outs before the end of the study. DATA COLLECTION AND ANALYSIS Two reviewers independently extracted data, assessed trial quality and resolved discrepancies by consensus. The outcomes were reported as odds ratios (OR) with 95% confidence intervals (CI). The data were combined with the fixed effects model. MAIN RESULTS Two studies with 1346 subjects met the inclusion criteria. Both trials were well designed, double - blind, placebo controlled trials, included participants with previous adenomas. The doses of supplementary elemental calcium used were 1200 mg daily for a mean duration of 4 years, and 2000 mg/day for three years. The rates of loss to follow -up were 14 % and 11%. For the development of recurrent colorectal adenoma, a reduction was found (OR 0.74, CI 0.58,0.95) when the results from both trials were combined. AUTHORS' CONCLUSIONS Although the evidence from two RCTs suggests that calcium supplementation might contribute to a moderate degree to the prevention of colorectal adenomatous polyps, this does not constitute sufficient evidence to recommend the general use of calcium supplements to prevent colorectal cancer.
Bayesian Pool-based Active Learning with Abstention Feedbacks

We study pool-based active learning with abstention feedbacks, where a labeler can abstain from labeling a queried example with some unknown abstention rate. This is an important problem with many useful applications. We take a Bayesian approach to the problem and develop two new greedy algorithms that learn both the classification problem and the unknown abstention rate at the same time. These are achieved by simply incorporating the estimated abstention rate into the greedy criteria. We prove that both of our algorithms have near-optimality guarantees: they respectively achieve a ${(1-\frac{1}{e})}$ constant factor approximation of the optimal expected or worst-case value of a useful utility function. Our experiments show the algorithms perform well in various practical scenarios.
Spatial heterogeneity of bacterial community structure in the sediments of the Pearl River estuary

Denaturing gradient gel electrophoresis (DGGE) and multivariate statistical analytical methods were applied to investigate the spatial variation of bacterial community structure in the Pearl River estuary sediment and to address the relationship between microbial community composition and bottom water chemistry in ten different stations. Preliminary results of sequencing analysis of the excised DGGE bands suggested that α-Proteobacteria, γ-Proteobacteria, Acidobacteria and Actinobacteria were the dominant bacterial groups in the Pearl River estuary sediment. Results of multidimensional scaling analysis of these field data suggested that the composition of bacterial communities varied with sampling sites. Finally, canonical correspondence analysis of the data of environmental variables and bacterial community suggested that bacterial community structure was significantly influenced by the change of environmental variables (total phosphorus, nitrite, ammonium, dissolved oxygen, pH and salinity).