Miracle-dz/UniFAR-FTUs huggingface dataset:
Virtual Interpersonal Touch: Expressing and Recognizing Emotions Through Haptic Devices

ABSTRACT This article examines the phenomenon of Virtual Interpersonal Touch (VIT), people touching one another via force-feedback haptic devices. As collaborative virtual environments become utilized more effectively, it is only natural that interactants will have the ability to touch one another. In the work presented here, we used relatively basic devices to begin to explore the expression of emotion through VIT. In Experiment 1, participants utilized a 2 DOF force-feedback joystick to express seven emotions. We examined various dimensions of the forces generated and subjective ratings of the difficulty of expressing those emotions. In Experiment 2, a separate group of participants attempted to recognize the recordings of emotions generated in Experiment 1. In Experiment 3, pairs of participants attempted to communicate the seven emotions using physical handshakes. Results indicated that humans were above chance when recognizing emotions via VIT but not as accurate as people expressing emotions through nonmediated handshakes. We discuss a theoretical framework for understanding emotions expressed through touch as well as the implications of the current findings for the utilization of VIT in human-computer interaction.
Treatment of the Acute Traumatic Acromioclavicular Separation

Injuries to the acromioclavicular joint occur commonly in athletes, especially those involved in contact sports. The majority of these injuries are type I and II acromioclavicular joint separations and are treated nonoperatively with rehabilitation. A rapid and full return to play is expected. Acute types IV, V, and VI are less common and operative intervention is recommended. The type III injury is more controversial and current trends are towards initial nonoperative management. Operative treatment is sought only when the athlete remains symptomatic with painful instability. However, some do support early intervention in the overhead athlete. The goal of operative intervention is to create a stiff and strong repair/reconstruction of the coracoclavicular ligaments while providing stability in all planes. This will allow early and more aggressive rehabilitation. Surgical treatment includes reconstruction of the coracoclavicular ligaments with an augmented coracoacromial ligament transfer and more recently tendon graft reconstructions. Biomechanical research supports an anatomic reconstruction of the ligaments to confer the most function and stability.
The Transverse Proximity Effect: A Probe to the Environment, Anisotropy, and Megayear Variability of QSOs

The transverse proximity effect is the expected decrease in the strength of the Lyα forest absorption in a QSO spectrum when another QSO lying close to the line of sight enhances the photoionization rate above that due to the average cosmic ionizing background. We select three QSOs from the Early Data Release of the Sloan Digital Sky Survey that have nearby foreground QSOs, with proper line-of-sight tangential separations of 0.50, 0.82, and 1.10 h-1 Mpc. We estimate that the ionizing flux from the foreground QSO should increase the photoionization rate by a factor (94, 13, 13) in these three cases, which would be clearly detectable in the first QSO and marginally so in the other two. We do not detect the transverse proximity effect. Three possible explanations are provided: an increase of the gas density in the vicinity of QSOs, time variability, and anisotropy of the QSO emission. We find that the increase of gas density near QSOs can be important if they are located in the most massive halos present at high redshift, but it is not enough to fully explain the absence of the transverse proximity effect. Anisotropy requires an unrealistically small opening angle of the QSO emission. Variability demands that the luminosity of the QSO with the largest predicted effect was much lower 106 yr ago, whereas the transverse proximity effect observed in the He II Lyα absorption in QSO 0302-003 by Jakobsen et al. implies a lifetime longer than 107 yr. A combination of all three effects may better explain the lack of Lyα absorption reduction. A larger sample of QSO pairs may be used to diagnose the environment, anisotropy, and lifetime distribution of QSOs.
Doubly Robust Policy Evaluation and Learning

We study decision making in environments where the reward is only partially observed, but can be modeled as a function of an action and an observed context. This setting, known as contextual bandits, encompasses a wide variety of applications including health-care policy and Internet advertising. A central task is evaluation of a new policy given historic data consisting of contexts, actions and received rewards. The key challenge is that the past data typically does not faithfully represent proportions of actions taken by a new policy. Previous approaches rely either on models of rewards or models of the past policy. The former are plagued by a large bias whereas the latter have a large variance. In this work, we leverage the strength and overcome the weaknesses of the two approaches by applying the doubly robust technique to the problems of policy evaluation and optimization. We prove that this approach yields accurate value estimates when we have either a good (but not necessarily consistent) model of rewards or a good (but not necessarily consistent) model of past policy. Extensive empirical comparison demonstrates that the doubly robust approach uniformly improves over existing techniques, achieving both lower variance in value estimation and better policies. As such, we expect the doubly robust approach to become common practice.
Design of a Nonhydrostatic Atmospheric Model Based on a Generalized Vertical Coordinate

Abstract The isentropic system of equations has particular advantages in the numerical modeling of weather and climate. These include the elimination of the vertical velocity in adiabatic flow, which simplifies the motion to a two-dimensional problem and greatly reduces the numerical errors associated with vertical advection. The mechanism for the vertical transfer of horizontal momentum is simply the pressure drag acting on isentropic coordinate surfaces under frictionless, adiabatic conditions. In addition, vertical resolution is enhanced in regions of high static stability, which leads to better resolution of features such as the tropopause. Negative static stability and isentropic overturning frequently occur in finescale atmospheric motion. This presents a challenge to nonhydrostatic modeling with the isentropic vertical coordinate. This paper presents a new nonhydrostatic atmospheric model based on a generalized vertical coordinate. The coordinate is specified in a manner similar to that of Konor an.
Perceiving Need for Lifestyle Counseling Findings from Finnish individuals at high risk of type 2 diabetes

RESULTSdIn total, 36% of men and 52% of women perceived the need for counseling. Most of the risk factors did not increase the perceived need for counseling. Those agreeing to attend supervised lifestyle intervention were more likely to report a perceived need than those who agreed on a self-initiated lifestyle change or those who refused to attend lifestyle intervention. The perceived need was associated with actual attendance in the lifestyle intervention only among women.
Responsiveness of the Berg Balance Scale in patients early after stroke

ABSTRACT The Berg Balance Scale (BBS) has previously shown good measurement properties. However, its ability to detect important change in patients early after stroke is still unknown. The purpose of the present study was to determine the minimal important change (MIC) and its relation to the minimal detectable change (MDC) for BBS in patients early after stroke. This prospective follow-up study included patients within the first 2 weeks after onset of stroke. The BBS, Barthel Index, and Scandinavian Stroke Scale were obtained at inclusion and 1 month later. At the follow-up assessment, the Patient Global Impression of Change was obtained. A receiver operating characteristic (ROC) curve was used to calculate the cut-off value for the MIC. Fifty-two patients (mean age of 78.7, SD 8.5 years) were included. All measures showed a significant improvement from baseline to follow-up. The ROC analysis identified a MIC of ≥6 BBS points, while the MDC was 5.97 BBS points at the 80% confidence level. This study shows that a change of 6 BBS point or more can be considered an important change for patients in the sub-acute phase after stroke, which also represents an 80% probability of exceeding the measurement error. A total of 80% of unchanged patients would display random fluctuations within the bounds of MDC80, while 20% of unchanged patients would exceed MDC80.
Combined niche and neutral effects in a microbial wastewater treatment community

It has long been assumed that differences in the relative abundance of taxa in microbial communities reflect differences in environmental conditions. Here we show that in the economically and environmentally important microbial communities in a wastewater treatment plant, the population dynamics are consistent with neutral community assembly, where chance and random immigration play an important and predictable role in shaping the communities. Using dynamic observations, we demonstrate a straightforward calibration of a purely neutral model and a parsimonious method to incorporate environmental influence on the reproduction (or birth) rate of individual taxa. The calibrated model parameters are biologically plausible, with the population turnover and diversity in the heterotrophic community being higher than for the ammonia oxidizing bacteria (AOB) and immigration into AOB community being relatively higher. When environmental factors were incorporated more of the variance in the observations could be explained but immigration and random reproduction and deaths remained the dominant driver in determining the relative abundance of the common taxa. Consequently we suggest that neutral community models should be the foundation of any description of an open biological system.
Pegylated interferon alfa-2a yields high rates of hematologic and molecular response in patients with advanced essential thrombocythemia and polycythemia vera.

PURPOSE We conducted a phase II study of pegylated interferon alfa-2a (PEG-IFN-alpha-2a) in patients with essential thrombocythemia (ET) and polycythemia vera (PV). PATIENTS AND METHODS Seventy-nine patients (40 with PV and 39 with ET) have been treated. Median time from diagnosis to PEG-IFN-alpha-2a was 54 months in patients with PV and 33 months in patients with ET. Eighty-one percent of patients had received prior therapy. The first three patients received PEG-IFN-alpha-2a at 450 microg weekly. As a result of poor tolerance, this dose was decreased in a stepwise manner to a current starting dose of 90 microg weekly. Seventy-seven patients are evaluable and have been observed for a median of 21 months. RESULTS The overall hematologic response rate was 80% in PV and 81% in ET (complete in 70% and 76% of patients, respectively). The JAK2(V617F) mutation was detected in 18 patients with ET and 38 patients with PV; sequential measurements by a pyrosequencing assay were available in 16 patients with ET and 35 patients with PV. The molecular response rate was 38% in ET and 54% in PV, being complete (undetectable JAK2(V617F)) in 6% and 14%, respectively. The JAK2(V617F) mutant allele burden continued to decrease with no clear evidence for a plateau. The tolerability of PEG-IFN-alpha-2a at 90 microg weekly was excellent. CONCLUSION PEG-IFN-alpha-2a resulted in remarkable clinical activity, high rates of molecular response, and acceptable toxicity in patients with advanced ET or PV. The ability of PEG-IFN-alpha-2a to induce complete molecular responses suggests selective targeting of the malignant clone.
Chromosome band 1q21 is recurrently gained in desmoid tumors

DNA sequence copy number changes were studied by comparative genomic hybridization (CGH) in 28 desmoid tumors. Changes were detected in 12 tumors (43%) with a mean of 1.4 changes per sample (range: 1 to 7). Out of 12 tumors associated with pregnancy or Gardner's syndrome, only two displayed changes. The minimal common regions of the most frequent gains were 1q21 (39%), chromosome 20 (32%), and 9p12 (21%). No high‐level amplifications were detected. Losses of DNA sequences were two times less frequent than gains and the minimal common regions of the most frequent losses were 6q16–q21 (14%), 5q14 (11%), and 13q21–q31 (11%). Genes Chromosomes Cancer 23:183–186, 1998. © 1998 Wiley‐Liss, Inc.
Incidence and modes of onset of early reinitiation of atrial fibrillation after successful internal cardioversion, and its prevention by intravenous sotalol

OBJECTIVES To study the incidence and mode of onset of early reinitiation of atrial fibrillation (ERAF) following successful internal cardioversion of chronic atrial fibrillation, and to determine the effects of sotalol in the prevention of ERAF. DESIGN The incidence and modes of onset of ERAF and the acute effects of intravenous sotalol in the prevention of ERAF were studied retrospectively. SETTING Electrophysiology laboratory at a university teaching hospital. PATIENTS 64 patients, mean (SD) age 62 (10) years, who underwent internal cardioversion of chronic atrial fibrillation (mean duration of atrial fibrillation 31 (39) months). MAIN OUTCOME MEASURES ECGs and intracardiac electrograms recorded during the internal cardioversion of atrial fibrillation using 3/3 ms biphasic, R wave synchronised shocks. RESULTS 52 patients (81%) had successful electrical cardioversion, and 20 (31%) of these had ERAF during the procedure. There was no clinical predictor for the occurrence of ERAF. Fifty eight episodes of ERAF were observed. Five ERAF episodes (9%) had preceding bradycardia and 53 (91%) of these were triggered by atrial premature beats with normal preceding heart rate. Atrial premature beats that reinitiated atrial fibrillation had a shorter coupling interval (333 (43) msv 396 (100), p < 0.001) and a lower prematurity index (0.44 (0.11) v 0.55 (0.14), p < 0.001) than those that did not reinitiate atrial fibrillation. Repeated shock delivery and increasing the defibrillation energy did not prevent ERAF. Intravenous sotalol infusion decreased the numbers of atrial premature beats and prolonged their coupling interval, and prevented ERAF after repeated defibrillation in 83% of patients with ERAF. CONCLUSIONS ERAF is a significant clinical problem after successful internal cardioversion of chronic atrial fibrillation, and was observed in up to 31% of patients. In most episodes, ERAF was triggered by short coupling atrial premature beats with preceding normal heart rate. Intravenous sotalol was effective in preventing ERAF in most cases.
Price dynamics in competitive agile spectrum access markets

We explore the price dynamics in a competitive market consisting of spectrum agile network service providers and users. Here, multiple self interested spectrum providers operating with different technologies and costs compete for potential customers. Different buyers or consumers may evaluate the same seller differently depending on their applications, operating technologies and locations. Two different buyer populations, the quality-sensitive and the price-sensitive are investigated, and the resulting collective price dynamics are studied using a combination of analysis and simulations. Various scenarios are considered regarding the nature and accuracy of information available to the sellers. A myopically optimal strategy is studied when full information is available, while a stochastic learning based strategy is considered when the information is limited. Cooperating groups may be formed among the sellers which will in-turn influence the group profit for those participants. Free riding phenomenon is observed under certain circumstances
Erasure code replication revisited

Erasure coding is a technique for achieving high availability and reliability in storage and communication systems. We revisit the analysis of erasure code replication and point out some situations when whole-file replication is preferred. The switchover point (from preferring whole-file replication to erasure code replication) is studied, and characterized using asymptotic analysis. We also discuss the additional considerations in building erasure code replication systems.
Pharmacological management of acute bronchiolitis

This article reviews the current knowledge base related to the pharmacological treatments for acute bronchiolitis. Bronchiolitis is a common lower respiratory illness affecting infants worldwide. The mainstays of therapy include airway support, supplemental oxygen, and support of fluids and nutrition. Frequently tried pharmacological interventions, such as ribavirin, nebulized bronchodilators, and systemic corticosteroids, have not been proven to benefit patients with bronchiolitis. Antibiotics do not improve the clinical course of patients with bronchiolitis, and should be used only in those patients with proven concurrent bacterial infection. Exogenous surfactant and heliox therapy also cannot be recommended for routine use, but surfactant replacement holds promise and should be further studied.
Incorporating Asymmetric Distributional Information in Robust Value-at-Risk Optimization

Value-at-Risk (VaR) is one of the most widely accepted risk measures in the financial and insurance industries, yet efficient optimization of VaR remains a very difficult problem. We propose a computationally tractable approximation method for minimizing the VaR of a portfolio based on robust optimization techniques. The method results in the optimization of a modified VaR measure, Asymmetry-Robust VaR (ARVaR), that takes into consideration asymmetries in the distributions of returns and is coherent, which makes it desirable from a financial theory perspective. We show that ARVaR approximates the Conditional VaR of the portfolio as well. Numerical experiments with simulated and real market data indicate that the proposed approach results in lower realized portfolio VaR, better efficient frontier, and lower maximum realized portfolio loss than alternative approaches for quantile-based portfolio risk minimization.
Widespread Myocardial Delivery of Heart-Derived Stem Cells by Nonocclusive Triple-Vessel Intracoronary Infusion in Porcine Ischemic Cardiomyopathy: Superior Attenuation of Adverse Remodeling Documented by Magnetic Resonance Imaging and Histology

Single-vessel, intracoronary infusion of stem cells under stop-flow conditions has proven safe but achieves only limited myocardial coverage. Continuous flow intracoronary delivery to one or more coronary vessels may achieve broader coverage for treating cardiomyopathy, but has not been investigated. Using nonocclusive coronary guiding catheters, we infused allogeneic cardiosphere-derived cells (CDCs) either in a single vessel or sequentially in all three coronary arteries in porcine ischemic cardiomyopathy and used magnetic resonance imaging (MRI) to assess structural and physiological outcomes. Vehicle-infused animals served as controls. Single-vessel stop-flow and continuous-flow intracoronary infusion revealed equivalent effects on scar size and function. Sequential infusion into each of the three major coronary vessels under stop-flow or continuous-flow conditions revealed equal efficacy, but less elevation of necrotic biomarkers with continuous-flow delivery. In addition, multi-vessel delivery resulted in enhanced global and regional tissue function compared to a triple-vessel placebo-treated group. The functional benefits after global cell infusion were accompanied histologically by minimal inflammatory cellular infiltration, attenuated regional fibrosis and enhanced vessel density in the heart. Sequential multi-vessel non-occlusive delivery of CDCs is safe and provides enhanced preservation of left ventricular function and structure. The current findings provide preclinical validation of the delivery method currently undergoing clinical testing in the Dilated cardiomYopathy iNtervention With Allogeneic MyocardIally-regenerative Cells (DYNAMIC) trial of CDCs in heart failure patients.
Social status and season of birth: a study of a metropolitan area in the southeastern United States.

An analysis of live birth statistics obtained from the Health Department of Fulton County, Georgia for 1967-1977 indicated that seasonal variation in birth was significantly related to maternal social status. Mothers were assigned to social status classification on the basis of whether they lived in an upper, upper middle, lower middle, or lower socioeconomic census tract. Periodic regression analysis and analysis of variance was applied to the data. Specific findings were 1) upper status groups showed no significant variation in births; 2) upper and lower middle classes showed a similar and a significant degree of seasonal variation with depressed birth levels from January-June and elevated levels from July-December; 3) lower class birth patterns showed more seasonal variation than the other classes; 4) the periodic curve accounted for 92.3% of the monthly variation in births for the lower class, 70.6% for the lower middle class, and 64.6% for the upper middle class; 5) the relationship between social status and seasonal variation in births held for both whites and non-whites; 6) seasonal variations were somewhat more marked for non-whites than for white in the lower and lower middle class; and 7) the observed relationship held throughout the 11 year period of observation. The results were of special concern given previous studies which found that children born in September-October entered school on the average earlier than other children and did less well in school than other students. Major findings were presented in graphic and tabular form.
Microbial biodiversity of Great Salt Lake, Utah

Microbial biodiversity is difficult to measure in extreme environments due to the inability to culture many of the species, especially from hypersaline environments. Great Salt Lake (GSL), Utah, USA offers a unique ecology to study microbial diversity across a salt gradient. GSL has increasing salt from South to North that varies from marine salt concentrations to saturation, respectively. We used three methods to examine the biodiversity of the GSL– traditional cultivation on solid media, 16S rRNA gene sequencing, multiplexed 16S rRNA gene hybridization to the phylochip, and DNA hybridization to the Geochip for metabolic diversity estimates. Over 40 isolates from the North Arm were obtained, while six were selected for identification. Isolates included gammaproteobacteria, bacilli, and actinobacteria. Sequencing the 16S rRNA genes for identification yielded 350 clones. Rarefaction curves indicated that this did not represent the bacterial diversity of the GSL, while estimation of the diversity with the Affymetrix phylochip produced over 1000 different genera in 31 different families. Estimation of the metabolic diversity found that genes for each activity were present in all three locations. The gene abundance was similar in all locations, except for metal use where the gene abundance declined as the salt gradient declined. This study provides the first evidence of the large microbial diversity supported by GSL to provide a large metabolic potential independent of the salt concentration.