Miracle-dz/UniFAR-FTUs huggingface dataset:
Place of birth, cancer beliefs and being current with colon cancer screening among US adults

Background Historically, studies suggested that immigrants acquire the risk of colorectal cancer (CRC) as US-born persons within the same generation. CRC risk of immigrants is largely unknown in this era of cancer screening and widespread immigration. We investigated the association of place of birth and cancer beliefs with uptake of CRC screening. Methods The 2007 Health Information National Trends Survey was used and 4,299 respondents (weighted population size=81,896,392) who were 50 years and older (3,960 US-born and 339 foreign-born) were identified. We defined being current with CRC screening guidelines as the use of fecal occult blood test within 1 year, sigmoidoscopy within 5 years, or colonoscopy within 10 years. We compared being up-to-date with CRC screening among foreign-born versus US-born respondents. Logistic regression models were used to calculate odds ratios (OR) and 95% confidence intervals (CI). Results Overall, 2,594 (63.3%) US-born and 208 (52.8%) foreign-born respondents were current with CRC screening. Foreign-born respondents were less current in unadjusted model (OR 0.65; 95% CI: 0.50-0.85) but became non-statistically significant after adjustment (OR 0.79; 95% CI: 0.51-1.24). Respondents who believed that screening finds cancer when it is easy to treat (OR 2.85; 95% CI: 1.44-3.61), those who believed that cancer can be cured when detected early (OR 1.56; 95% CI: 1.20-2.00), and those who worry about getting cancer (OR 1.34; 95% CI: 1.10-1.61) were likely to be current with CRC screening. However, respondents with fatalistic beliefs were borderline less likely to be current (OR 0.82; 95% CI: 0.65-1.04). Conclusion There is a need to improve education on CRC screening, particularly among foreign-born adults.
Music-Supported Therapy induces plasticity in the sensorimotor cortex in chronic stroke: A single-case study using multimodal imaging (fMRI-TMS)

Primary objective: Music-Supported Therapy (MST) has been developed recently in order to improve the use of the affected upper extremity after stroke. This study investigated the neuroplastic mechanisms underlying effectiveness in a patient with chronic stroke. Methods: MST uses musical instruments, a midi piano and an electronic drum set emitting piano sounds, to retrain fine and gross movements of the paretic upper extremity. Data are presented from a patient with a chronic stroke (20 months post-stroke) with residual right-sided hemiparesis who took part in 20 MST sessions over the course of 4 weeks. Results: Post-therapy, a marked improvement of movement quality, assessed by 3D movement analysis, was observed. Moreover, functional magnetic resonance imaging (fMRI) of a sequential hand movement revealed distinct therapy-related changes in the form of a reduction of excess contralateral and ipsilateral activations. This was accompanied by changes in cortical excitability evidenced by transcranial magnetic stimulation (TMS). Functional MRI in a music listening task suggests that one of the effects of MST is the task-dependent coupling of auditory and motor cortical areas. Conclusions: The MST appears to be a useful neurorehabilitation tool in patients with chronic stroke and leads to neural reorganization in the sensorimotor cortex.
Deconstructing the Energy Consumption of the Mobile Page Load

Modeling the energy consumption of applications on mobile devices is an important topic that has received much attention in recent years. However, there has been very little research on modeling the energy consumption of the mobile Web. This is primarily due to the short-lived yet complex page load process that makes it infeasible to rely on coarse-grained resource monitoring for accurate power estimation. We present RECON, a modeling approach that accurately estimates the energy consumption of any Web page load and deconstructs it into the energy contributions of individual page load activities. Our key intuition is to leverage low-level application semantics in addition to coarse-grained resource utilizations for modeling the page load energy consumption. By exploiting fine-grained information about the individual activities that make up the page load, RECON enables fast and accurate energy estimations without requiring complex models. Experiments across 80 Web pages and under four different optimizations show that RECON can estimate the energy consumption for a Web page load with an average error of less than 7%. Importantly, RECON helps to analyze and explain the energy effects of an optimization on the individual components of Web page loads.
DataSlicer: Task-Based Data Selection for Visual Data Exploration

In visual exploration and analysis of data, determining how to select and transform the data for visualization is a challenge for data-unfamiliar or inexperienced users. Our main hypothesis is that for many data sets and common analysis tasks, there are relatively few "data slices" that result in effective visualizations. By focusing human users on appropriate and suitably transformed parts of the underlying data sets, these data slices can help the users carry their task to correct completion. To verify this hypothesis, we develop a framework that permits us to capture exemplary data slices for a user task, and to explore and parse visual-exploration sequences into a format that makes them distinct and easy to compare. We develop a recommendation system, DataSlicer, that matches a "currently viewed" data slice with the most promising "next effective" data slices for the given exploration task. We report the results of controlled experiments with an implementation of the DataSlicer system, using four common analytical task types. The experiments demonstrate statistically significant improvements in accuracy and exploration speed versus users without access to our system.
Formaldehyde in high school classrooms

Schools have a unique place in the fabric of America. Yet there is growing evidence that poor indoor air quality (IAQ) leads to increases in student illnesses and absenteeism, decreases in academic performance, and increased upper-respiratory problems in teachers. Past studies of IAQ in schools have been deficient in many ways. Only four of 735 published papers have involved actual measurements in high schools in North America. There has been little progress in determining the actual agents responsible for adverse effects when ventilation is inadequate. Few studies have focused on irritating oxygenated VOCs (OVOCs) and their sources. The objectives of this thesis were to better understand the levels and temporal variation of one OVOC, formaldehyde (HCHO), in 46 high school classrooms in Central Texas, to explore differences in HCHO concentrations between portable and traditional classrooms, and to compare differences between two HCHO measurement methods. Results indicate that HCHO concentrations in high school classrooms are in the range of those found in past school studies. There were statistically no differences in HCHO concentrations between portable and
Infertility and coeliac disease.

BACKGROUND: Coeliac women may suffer from gynaecological and obstetric complications. It is possible that these complications are the first symptom of coeliac disease. AIMS: To investigate the occurrence of subclinical coeliac disease in patients with infertility or recurrent miscarriages. SUBJECTS: Women of reproductive age who were attending the hospital because of either primary or secondary infertility, or two or more miscarriages. Women undergoing sterilisation served as control subjects. METHODS: The diagnostic investigation for infertility included the endocrine status, diagnostic laparoscopy, investigation of tubal patency, postcoital test, and semen analysis of the partner. Circulating antibodies against IgA class reticulin and gliadin were used in screening for coeliac disease. In positive cases, the diagnosis was confirmed by small bowel biopsy specimens. RESULTS: Four (2.7%) of 150 women in the infertility group, and none of the 150 control subjects were found to have coeliac disease (p = 0.06). All four women with coeliac disease suffered from infertility of unexplained origin. Altogether 98 women had no discoverable reason for infertility. Thus, in this subgroup the frequency of coeliac disease was 4.1% (four of 98), the difference from the control group being statistically significant (p = 0.02). None of the coeliac women had extensive malabsorption, but two had iron deficiency anaemia. One women with coeliac disease has had a normal delivery. None of the 50 women with miscarriage had coeliac disease. CONCLUSION: Patients having fertility problems may have subclinical coeliac disease, which can be detected by serological screening tests. Silent coeliac disease should be considered in the case of women with unexplained infertility.
CT coronary angiography predicts the outcome of percutaneous coronary intervention of chronic total occlusion.

BACKGROUND The success rate of percutaneous coronary intervention (PCI) of chronic total occlusions (CTO) is relatively low. Further evaluation of CTO lesion with CT coronary angiography (CT-CA) may help to better select patients that would benefit from percutaneous revascularization. We aimed to test the possible association between failed PCI and transluminal calcification of CTO as assessed by CT-CA. METHODS Patients with CTO awaiting PCI were scanned with a 16-slice CT. A cardiologist and a radiologist assessed transluminal calcification of CTO lesions on CT images while an interventional cardiologist at a core laboratory assessed conventional variables of invasive fluoroscopic coronary angiography (FCA) associated with failed PCI of CTO. The significance of CT and FCA variables in association with failed PCI were analyzed. RESULTS In a cohort of 39 patients with 43 CTO lesions, 24 lesions were successfully revascularized. Transluminal calcification > or =50% as assessed on CT-CA was strongly associated with failed PCI (odds ratio [OR] of PCI success = 0.10, 95% confidence interval [CI]: 0.02-0.47, P = 0.003). Blunt stump as seen on FCA was also associated with failed PCI (OR of PCI success = 0.24, 95% CI: 0.07-0.86, P = 0.029). There was no significant evidence to support that the duration of CTO, presence of side branch and bridging collaterals, and the absence of microchannels as assessed with FCA were associated with failed PCI. On multivariate analysis, transluminal calcification > or =50% on CT-CA was the only significant predictor of failed PCI. CONCLUSIONS Heavy transluminal calcification as assessed with CT-CA is an independent predictor of failed PCI of CTO. CT-CA may have a role in the work-up of CTO patients prior to PCI.
The Arabidopsis thaliana F-box gene HAWAIIAN SKIRT is a new player in the microRNA pathway

In Arabidopsis, the F-box HAWAIIAN SKIRT (HWS) protein is important for organ growth. Loss of function of HWS exhibits pleiotropic phenotypes including sepal fusion. To dissect the HWS role, we EMS-mutagenized hws-1 seeds and screened for mutations that suppress hws-1 associated phenotypes. We identified shs-2 and shs-3 (suppressor of hws-2 and 3) mutants in which the sepal fusion phenotype of hws-1 was suppressed. shs-2 and shs-3 (renamed hst-23/hws-1 and hst-24/hws-1) carry transition mutations that result in premature terminations in the plant homolog of Exportin-5 HASTY (HST), known to be important in miRNA biogenesis, function and transport. Genetic crosses between hws-1 and mutant lines for genes in the miRNA pathway also suppress the phenotypes associated with HWS loss of function, corroborating epistatic relations between the miRNA pathway genes and HWS. In agreement with these data, accumulation of miRNA is modified in HWS loss or gain of function mutants. Our data propose HWS as a new player in the miRNA pathway, important for plant growth.
Survival of adult islet grafts from transgenic pigs with N‐acetylglucosaminyltransferase‐III (GnT‐III) in cynomolgus monkeys

Abstract: Background: Because of a severe shortage of human donor pancreases, pig islets are considered to be an attractive donor source. Our previous in vitro study revealed that adult pig islets have strong non‐Galα1‐3Galβ1‐4GlcNAc‐R (α‐Gal) antigenicity, including the Hanganutziu‐Deicher (H‐D) antigen, especially in N‐linked sugars. In this study, the issue of whether islets from N‐acetylglucosaminyltransferase‐III (GnT‐III) transgenic pigs can prolong their survival in cynomolgus monkeys was examined.
Increased Synapse Formation Obtained by T Cell Epitopes Containing a CxxC Motif in Flanking Residues Convert CD4+ T Cells into Cytolytic Effectors

The nature of MHC class II-binding epitopes not only determines the specificity of T cell responses, but may also alter effector cell functions. Cytolytic CD4+ T cells have been observed primarily in anti-viral responses, but very little is known about the conditions under which they can be elicited. Their potential as regulators of immune responses, however, deserves investigations. We describe here that inclusion of a thiol-disulfide oxidoreductase motif within flanking residues of class II-restricted epitopes results, both in vitro and in vivo, in elicitation of antigen-specific cytolytic CD4+ T cells through increased synapse formation. We show that both naïve and polarized CD4+ T cells, including Th17 cells, can be converted by cognate recognition of such modified epitopes. Cytolytic CD4+ T cells induce apoptosis on APCs by Fas-FasL interaction. These findings potentially open the way towards a novel form of antigen-specific immunosuppression.
Remote SST forcing on Indian summer monsoon extreme years in AGCM experiments

An ensemble of AMIP‐type experiments with prescribed interannual varying sea surface temperature (SST) and different initial conditions is used to study the relationship between Indian summer monsoon extreme conditions and the El Nino Southern Oscillation (ENSO). Based on the selection of extreme monsoon rainfall years ‘In Phase’ or ‘Out of Phase’ with respect to the observations, this study identifies specific SST and atmospheric circulation patterns responsible for the remote forcing on the monsoon. A clear common characteristic of externally forced extreme monsoon years is identified with an ENSO pattern having summer SST anomalies of the same sign in the tropical Pacific Ocean but also in the Indian and Atlantic tropical sectors. This finding assumes that the SST pattern in summer is enough to modulate the Walker circulation and consequently to suppress or enhance convection over South Asia, even if it does not evolve into an ENSO event. The analysis of the ‘Out of Phase’ cases (i.e. when the model reproduces a weak monsoon instead of a strong one, or the reverse) reveals how the model wrongly responds to the SST forcing, ignoring other processes like ocean–atmosphere coupling. Once ENSO is linearly removed the main source of remote forcing for strong (weak) monsoon characteristics over India is the tropical Atlantic with negative (positive) anomalies, and with weak anomalies of the same sign located in the south Indian Ocean. The results of the role of the forcing from the tropical Atlantic are also confirmed by a set of atmospheric model experiments where interannually varying SST is prescribed only in the Atlantic Ocean, while the rest of the SST is climatological.
Non-Negative Matrix Factorization for the Analysis of Complex Gene Expression Data: Identification of Clinically Relevant Tumor Subtypes

Non-negative matrix factorization (NMF) is a relatively new approach to analyze gene expression data that models data by additive combinations of non-negative basis vectors (metagenes). The non-negativity constraint makes sense biologically as genes may either be expressed or not, but never show negative expression. We applied NMF to five different microarray data sets. We estimated the appropriate number metagens by comparing the residual error of NMF reconstruction of data to that of NMF reconstruction of permutated data, thus finding when a given solution contained more information than noise. This analysis also revealed that NMF could not factorize one of the data sets in a meaningful way. We used GO categories and pre defined gene sets to evaluate the biological significance of the obtained metagenes. By analyses of metagenes specific for the same GO-categories we could show that individual metagenes activated different aspects of the same biological processes. Several of the obtained metagenes correlated with tumor subtypes and tumors with characteristic chromosomal translocations, indicating that metagenes may correspond to specific disease entities. Hence, NMF extracts biological relevant structures of microarray expression data and may thus contribute to a deeper understanding of tumor behavior.
Novel presenilin 1 mutation (S170F) causing Alzheimer disease with Lewy bodies in the third decade of life.

BACKGROUND Cases of early-onset Alzheimer disease (AD) with an autosomal dominant inheritance pattern (familial AD [FAD]) are rare but have greatly advanced our understanding of the molecular pathogenesis of AD. We describe herein a kindred with very early-onset FAD (age, <40 years) with unusual pathological features and a novel mutation in the presenilin 1 (PSEN1) gene (S170F) and review the existing literature on very early-onset FAD. OBJECTIVE To analyze the neuropathological and genetic features of a family with onset of AD in the third decade of life. DESIGN, SETTING, AND PARTICIPANTS The proband underwent full clinical assessment and postmortem examination at the Washington University Alzheimer's Disease Research Center, St Louis, Mo. Limited pathological samples and autopsy records of 2 affected family members were available. The proband underwent screening for mutations in genes linked with FAD. RESULTS Dementia developed in 3 family members in this kindred at a mean age of 27 years; the proband had myoclonus, seizures, and rigidity, similar to findings in previously described kindreds with PSEN1 mutations. All 3 family members were confirmed to have AD by neuropathological examination. The proband also had widespread Lewy body pathology in the brainstem, limbic areas, and neocortex; specific staining for Lewy bodies was not performed in the other 2 family members. The proband had a single mutation (S170F) in exon 6 of the PSEN1 gene, which segregates with disease. CONCLUSIONS A novel PSEN1 mutation causes very-early-onset FAD with associated Lewy bodies. To our knowledge, this kindred has the earliest reported onset of pathologically confirmed FAD and dementia with Lewy bodies.
Lake Kinneret (Israel): New insights into Holocene regional palaeoclimate variability based on high-resolution multi-proxy analysis

The southern Levant is a Mediterranean climate zone of complex variability in which uncertainty remains in regional palaeoclimate reconstruction. In spite of the proven value of diatoms in circum-Mediterranean palaeoenvironmental research, their potential remains largely unexplored in the southern Levant region. In this study, we generate a new, high-resolution multi-proxy record for the last ca. 9000 cal. yr BP, supported by diatom data and key biological, mineralogical and geochemical indicators preserved in a 17.8-m-long sediment sequence recovered from Lake Kinneret (the Sea of Galilee), Israel. During the Holocene, well-correlated shifts in the diatom, minero-geochemical and palynological data indicate marked lake-level variation over time as well as changes in the trophic state of Lake Kinneret. Our results are particularly important in improving the reconstruction of Holocene lake-level variation, and thus past moisture availability. Diatom-inferred lake-level oscillations correlate well with the output from climatic models from the Levantine region and clarify previous uncertainty concerning regional variation in moisture availability. The Early Holocene (from ca. 9000 to 7400 cal. yr BP) was characterized by lake-level shifts due to fluctuating dry-wet climate conditions. During the mid-Holocene (from 7400 to 2200 cal. yr BP), a stable, deep lake-level phase persisted due to high humidity. The lake level of modern Lake Kinneret not only fluctuates seasonally with available moisture, but has also been influenced for ca. 2000 years by the impacts of water abstraction for human consumption and agriculture. Over the last 9000 cal. yr BP, the trophic state of Lake Kinneret has changed from an oligotrophic to a meso- to eutrophic environment, mainly triggered by increased human impact from around 2200 cal. yr BP onwards. The lake’s ecosystem status was not strongly affected by the documented major changes in human occupation patterns during the mid-Holocene, when a relatively stable environment persisted.
How Does Grade Configuration Impact Student Achievement ? Evaluating the Effectiveness of K-8 Schools

Recently, there has been a move towards K-8 schools as opposed to stand-alone middle schools. In this paper, we examine the effect of enrollment in a stand-alone middle school relative to a K-8 school using a longitudinal data from an anonymous district using an alternative identification strategy from the previous literature and find results inconsistent with previous research. Overall, our results from the geographic boundary approach are less supportive of a K-8 policy and raises questions of the robustness of the previous conclusions.
Endothelial Caveolar Hub Regulation of Adenosine Triphosphate–Induced Endothelial Nitric Oxide Synthase Subcellular Partitioning and Domain-Specific Phosphorylation

ATP leads to endothelial NO synthase (eNOS)/NO-mediated vasodilation, a process hypothesized to depend on the endothelial caveolar eNOS partitioning and subcellular domain-specific multisite phosphorylation state. We demonstrate herein that, in both the absence and presence of ATP, the uterine artery endothelial caveolae contain specific protein machinery related to subcellular partitioning and act as specific focal “hubs” for NO- and ATP-related proteins. ATP-induced eNOS regulation showed a complex set of multisite posttranslational phosphorylation events that were closely associated with the enzyme's partitioning between caveolar and noncaveolar endothelial subcellular domains. The comprehensive model that we present demonstrates that ATP repartitioned eNOS between the caveolar and noncaveolar subcellular domains; specifically, the stimulatory PSer635eNOS was substantially higher in the caveolar pool with subcellular domain-independent increased levels on ATP treatment. The stimulatory PSer1179eNOS was not altered by ATP treatment. However, the inhibitory PThr495eNOS was regulated predominantly in the caveolar domain with decreased levels on ATP action. In contrast, the agonist-specific PSer114eNOS was localized in the noncaveolar pool with increased levels on ATP stimulation. Thus, the endothelial caveolar membrane system plays a pivotal role(s) in ATP-associated subcellular partitioning and possesses the relevant protein machinery for ATP-induced NO regulation. Furthermore, these subcellular domain-specific phosphorylation/dephosphorylation events provide evidence relating to eNOS spatio-temporal dynamics.