Miracle-dz/UniFAR-FTUs huggingface dataset:
Drug-induced long QT in adult psychiatric inpatients: the 5-year cross-sectional ECG Screening Outcome in Psychiatry study.

OBJECTIVE The authors aimed to determine the prevalence of drug-induced long QT at admission to a public psychiatric hospital and to document the associated factors using a cross-sectional approach. METHOD All ECG recordings over a 5-year period were reviewed for drug-induced long QT (heart-rate corrected QT ≥500 ms and certain or probable drug imputability) and associated conditions. Patients with drug-induced long QT (N=62) were compared with a sample of patients with normal ECG (N=143). RESULTS Among 6,790 inpatients, 27.3% had abnormal ECG, 1.6% had long QT, and 0.9% qualified as drug-induced long QT case subjects. Sudden cardiac death was recorded in five patients, and torsade de pointes was recorded in seven other patients. Relative to comparison subjects, patients with drug-induced long QT had significantly higher frequencies of hypokalemia, hepatitis C virus (HCV) infection, HIV infection, and abnormal T wave morphology. Haloperidol, sertindole, clotiapine, phenothiazines, fluoxetine, citalopram (including escitalopram), and methadone were significantly more frequent in patients with drug-induced long QT. After adjustment for hypokalemia, HCV infection, HIV infection, and abnormal T wave morphology, the effects of haloperidol, clotiapine, phenothiazines, and citalopram (including escitalopram) remained statistically significant. Receiver operating characteristic curve analysis based on the number of endorsed factors per patient indicated that 85.5% of drug-induced long QT patients had two or more factors, whereas 81.1% of patients with normal ECG had fewer than two factors. CONCLUSIONS Drug-induced long QT and arrhythmia propensity substantially increase when specific psychotropic drugs are administered to patients with hypokalemia, abnormal T wave morphology, HCV infection, and HIV infection.
Identity work: stories told in learning to teach physical education

Pre-service teachers bring to their university studies particular world views and understandings of themselves and others around health and physical activity. Their biographies and experiences in school physical education, sport and oyther societal institutions inform these perspectives and understandings. These in turn work to mediate university learning, interactions with the physical education learning area and understandings of teaching and learning processes. The biographies of pre-service teachers can provide valuable insights into how and why particular constructions of self are possible within given historical times, locations and events. In the context of teacher preparation in physical education this research attempts to investigate the construction of a teaching identity and pedagogical practices. Specifically it attempts to reveal how various cultures of physical activity, fitness and sport shape the subjective experiences of pre-service teachers as well as how different theoretical frameworks can be used to provide particular readings and deeper understandings of the stories told. Pre-service teachers were asked to respond to a series of open-ended questions regarding their personal experiences of physical education, sport and teacher preparation as well as the implications of these experiences for notions of themselves as an emerging teacher in the learning area. In the process of analysis attempt was made to identify the meanings students made in these contexts and their influence on the construction of a teaching identity. The findings give evidence of the complex and multiple ways that teaching identities are constructed as well as the processes whereby particular pedagogical practices are adopted.
Anatomical and functional recovery of the goldfish (Carassius auratus) ear following noise exposure

SUMMARY Fishes can regenerate lateral line and inner ear sensory hair cells that have been lost following exposure to ototoxic antibiotics. However, regenerative capabilities following noise exposure have not been explored in fish. Moreover, nothing is known about the functional relationship between hair cell damage and hearing loss, or the time course of morphological versus functional recovery in fishes. This study examines the relationship between hair cell damage and physiological changes in auditory responses following noise exposure in the goldfish (Carassius auratus). Goldfish were exposed to white noise (170 dB re. 1 μPa RMS) for 48 h and monitored for 8 days after exposure. Auditory thresholds were determined using the auditory evoked potential technique, and morphological hair cell damage was analyzed using phalloidin and DAPI labeling to visualize hair cell bundles and nuclei. A TUNEL assay was used to identify apoptotic cells. Following noise exposure, goldfish exhibited a significant temporary threshold shift (TTS; ranging from 13 to 20 dB) at all frequencies tested (from 0.2-2 kHz). By 7 days post-exposure, goldfish hearing recovered significantly (mean TTS<4 dB). Increased apoptotic activity was observed in the saccules and lagenae between 0 and 2 days post-exposure. Immediately after noise exposure, the central and caudal regions of saccules exhibited significant loss of hair bundles. Hair bundle density in the central saccule recovered by the end of the experiment (8 days post-exposure) while bundle density in the caudal saccule did not return to control levels in this time frame. These data demonstrate that goldfish inner ear epithelia show damage following noise exposure and that they are capable of significant regenerative responses similar to those seen following ototoxic drug treatment. Interestingly, functional recovery preceded morphological recovery in the goldfish saccule, suggesting that only a subset of hair cells are necessary for normal auditory responses, at least to the extent that hearing was measured in this study.
Os estados no Suas: uma análise da capacidade institucional dos governos estaduais na assistência social

The article outlines a diagnosis of the institutional capacity of Brazilian states in the social assistance from the analysis of three aspects: financial, administrative and political. This is a comparison of the 26 states of the federation and the Distrito Federal using secondary data from the Pesquisa de Informacoes Basicas Estaduais do IBGE from 2012, from the Sistema de Coleta de Dados Contabeis from Federal Government (SISTN) and from the Relatorio de Informacoes Sociais do Ministerio do Desenvolvimento Social e Combate a Fome from 2011. The data show that there may be different ways of states of performance even within a national system. The heterogeneity occur because to discretion conferred by the institutional design of Suas the state one. This situation contributes to the perpetuation of existing regional inequalities, precluding the consolidation of the Brazilian welfare state.
Teacher Beliefs and Practices of Kindergarten Teachers in Hong Kong

A KEY EDUCATIONAL REFORM PROPOSAL made in 2000 is to build a new culture for quality early childhood education through upgrading professional competence. Teachers are an important element of high-quality, developmentally appropriate early childhood programs. The Teacher Beliefs and Practices Survey (TBS) based on 2009 NAEYC Developmentally Appropriate Practice (DAP) guidelines was used to measure kindergarten teachers' beliefs and practices in Hong Kong. Confirmatory Factor Analysis (CFA) is used to validate the survey for the Hong Kong sample. Findings indicated that the three-factor model of TBS and four-factor model of Instructional Activities Scale (IAS) were fitted to measure Hong Kong samples. Quality of early childhood education has been enhanced with the strong agreement of appropriate teaching beliefs and practices among kindergartens teachers in Hong Kong.
Coverage of Veterans of the Wars in Iraq and Afghanistan in the U.S. Media

To evaluate how the media frames veterans of the wars in Iraq and Afghanistan, this study systematically assesses the discourse on Iraq and Afghanistan veterans in the New York Times and Washington Post from 2003 to 2011. Our analysis of a stratified sample of 151 articles featuring veterans from either the wars in Iraq or Afghanistan finds that the media frames veterans as damaged by their service but deserving of government benefits and social assistance. When the media frames veterans as actively engaging in society, their social engagement is often because of or despite their injuries or mistreatment. We find interplay between victimization and deservingness such that depictions of the cohort as physically and mentally damaged complement and justify arguments for a sustained high level of benefits to accommodate the needs of veterans. We thus argue that generous benefits for veterans partly stem from their depiction as having suffered from their service.
Functional outcome in surgical management of midshaft clavicle fractures fixed with precontoured plate in adults

Background: Fractures of clavicle are one of the most common fractures in traumatic injury around shoulder girdle as the bone is sub cutaneous throughout. Fractures of middle third clavicle generally occur either by high energy or low energy impact. These fractures have been treated traditionally by nonoperative methods. Although many close reduction methods have been described it has been recognised that complete reduction is practically impossible. Open reduction and internal fixation have become the mainstay of treatment for most of the midshaft fractures, as these operative methods restores the anatomy, biomechanics and contact loading characteristics of the clavicle. Objectives: To study the functional outcome of surgically managed clavicle fractures with precontoured locking plate. Methods: A prospective study of 60 cases of midshaft clavicle fractures in adults, Managed surgically by open reduction and fixation with precontoured plate during the period from May 2014 to April 2016 satisfying the inclusion and exclusion criteria were studied. The functional outcome was evaluated using the Constant and Murley scoring system. Results: In our study we achieved 93.4% excellent to good results, 5% fair results, 1.6% Poor results. The results were comparable to other studies. Interpretation & Conclusion: The operative results were satisfactory in 93.4% cases, with good to excellent functional outcome. This study shows rigid fixation with precontoured plate and screws for fresh displaced or comminuted middle third clavicle fracture gives good anatomical reduction, immediate pain relief and prevents the development of shoulder stiffness and non-union and thus on the whole shows good functional outcome by early mobilisation and hence patient to their functional activities.
Protección y defensa del patrimonio minero en España

Recientemente hemos asistido a una progresiva sensibilizacion hacia la proteccion y conservacion del patrimonio vinculado a las actividades mineras e industriales. La comunidad cientifica, la poblacion y las administraciones han desarrollado una importante labor tendente a valorizar correctamente este legado. La reinvencion de muchos territorios mineros en actuaciones vinculadas con el turismo (museos mineros, centros de interpretacion, parques mineros, etc.) ha contribuido a evitar la perdida de esta herencia que forma parte de la memoria colectiva de la poblacion, siendo especialmente destacable tambien, el trabajo de las asociaciones a traves de reuniones cientificas y publicaciones. Junto a todo ello, la aparicion de un documento como la Carta de El Bierzo para la Conservacion del Patrimonio Industrial Minero en Espana sirve para concretar las bases conceptuales y metodologicas sobre cualquier actuacion relacionada con la recuperacion del patrimonio minero.
Bioorthogonal Non-Canonical Amino Acid Tagging ( BONCAT ) enables time-resolved 1 analysis of protein synthesis in native plant tissue 2 3

Bioorthogonal Non-Canonical Amino Acid Tagging (BONCAT) enables time-resolved 1 analysis of protein synthesis in native plant tissue 2 3 Weslee S. Glenn, Shannon E. Stone, Samuel H. Ho, Michael J. Sweredoski, Annie Moradian, Sonja 4 Hess, Julia Bailey-Serres and David A. Tirrell 5 6 1 – Division of Chemistry and Chemical Engineering; California Institute of Technology; Pasadena, CA 7 91125 8 2 – Proteome Exploration Laboratory; California Institute of Technology; Pasadena, CA 91125 9 3 – Center for Plant Cell Biology; University of California at Riverside; Riverside, CA 92521 10 11 Research Area: Breakthrough Technologies 12 13 Summary: Pulsing the non-canonical amino acid azidohomoalanine into Arabidopsis thaliana seedlings 14 enables in-gel visualization, physical enrichment, and identification of newly synthesized proteins. 15 16 List of Author Contributions: W.S. G. conceived of and implemented the project, and performed most of 17 the experiments with contributions from all other authors. S.H. H. , J.B-S and W.S. G. designed and 18 conducted gel imaging and immunoblotting experiments. A.M., S.H. and W.S. G. designed and ran the mass 19 spectrometry experiments. S.E. S. , M.J.S. , S.H. , J. B-S and W.S. G. conducted all bioinformatic analyses of 20 the mass spectrometry data. S.E. S. , M.J.S. and W.S. G. constructed figures with input from all other 21 authors. W.S. G, J.B-S and D.A. T. wrote the article with valuable contributions from all authors. 22
Large‐scale cosmic microwave background anisotropies and dark energy

In this note we investigate the effects of perturbations in a dark energy component with a constant equation of state on large scale cosmic microwave background anisotropies. The inclusion of perturbations increases the large scale power. We investigate more speculative dark energy models with w < 1 and find the opposite behaviour. Overall the inclusion of perturbations in the dark energy component increases the degeneracies. We generalise the parameterization of the dark energy fluctuations to allow for an arbitrary constant sound speeds and show how constraints from cosmic microwave background experiments change if this is included. Combining cosmic microwave background with large scale structure, Hubble parameter and Supernovae observations we obtain w = 1.02 ± 0.16 (1σ) as a constraint on the equation of state, which is almost independent of the sound speed chosen. With the presented analysis we find no significant constraint on the constant speed of sound of the dark energy component.
Antibody Recognition of Shiga Toxins (Stxs): Computational Identification of the Epitopes of Stx2 Subunit A to the Antibodies 11E10 and S2C4

We have recently developed a new method to predict the epitopes of the antigens that are recognized by a specific antibody. In this work, we applied the method to identify the epitopes of the Shiga toxin (Stx2 subunit A) that were bound by two specific antibodies 11E10 and S2C4. The predicted epitopes of Stx2 binding to the antibody 11E10 resembles the recognition surface constructed by the regions of Stx2 identified experimentally. For the S2C4, our results indicate that the antibody recognizes the Stx2 at two different regions on the protein surface. The first region (residues 246-254: ARSVRAVNE) is similar to the recognition region of the 11E10, while the second region is formed by two epitopes. The second region is particularly significant because it includes the amino acid sequence region that is diverse between Stx2 and other Stx (residues 176-188: QREFRQALSETAPV). This new recognition region is believed to play an important role in the experimentally observed selectivity of S2C4 to the Stx2.
Effects of sulfuric acid aerosol on respiratory mechanics and mucociliary particle clearance in healthy nonsmoking adults.

Ten healthy nonsmokers inhaled 0.5 µm (αg=1.9) H2SO4 at 0 (control), 110,330, and 980 µg/m3 for one hour via nasal mask in random sequence on four separate days. Respiratory mechanical function was assessed before and 1 /2, 2 and 4 hrs after the H2SO4 exposure. A 99mTc tagged Fe2O3 aerosol (7.5 µm aerodynamic diameter, αg≤1.1) was inhaled ∼10 min before each H2SO4 exposure, with flow rate=1.0 L/s, tidal volume=1.0 L and respiratory rate=15/min. Thoracic retention of the deposited radioactivity was monitored using collimated scintillation detectors. A tracheal probe was used to determine the tracheal mucociliary transport rates (TMTR's) of local concentrations of activity. Bronchial mucociliary clearance was markedly altered in a dose dependent pattern in six of the individuals and in the group as a whole. Exposures to 110 µg/m3 resulted in a significant acceleration in mucociliary clearance (group mean tracheobronchial clearance half-time, , decreased from 80 to 50 min). Exposures to 980 µg/m3 caused a si.
Art Therapy, Men and the Expressivity Gap

Men as a discrete subject group and the gender-based nuances of their visual expression is a relatively unexplored art therapy research topic. The author describes a study designed to investigate the lived experience of a male subject in communicating about an episode of major depression, through both verbal communication and associations to visual art produced by the subject. Results of the study illustrate how the client's visual expression was extremely attenuated and impoverished in contrast to his rich, extremely detailed verbal expression. The author suggests that the ways in which male experience is depicted, covered over, denied, and inadvertently revealed merit deeper investigation in the field of art therapy.
Novel porous single-crystalline ZnO nanosheets fabricated by annealing ZnS(en)0.5 (en = ethylenediamine) precursor. Application in a gas sensor for indoor air contaminant detection

Novel single-crystalline ZnO nanosheets with porous structure have been fabricated by annealing ZnS(en)0.5 (en = ethylenediamine) complex precursor. The morphology and structure observations performed by field emission scanning electronic microscopy (FESEM) and high-resolution transmission electron microscopy (HRTEM) indicate that numerous mesopores with a diameter of about 26.1 nm distribute all through each nanosheet with a high density. The transformation of structure and composition of samples obtained during thermal treatment processes were investigated by x-ray diffraction (XRD), x-ray photoelectron spectrometry (XPS), thermogravimetric analysis (TGA), and Fourier transform infrared (FTIR) absorption spectroscopy. The formation mechanism of the porous structure is proposed. For indoor air contaminant detection in which formaldehyde and ammonia are employed as target gases, the as-prepared ZnO nanosheets were applied for the fabrication of gas sensors. It was found that the as-fabricated sensors not only exhibit highly sensitive performance, e.g., high gas-sensing responses, short response and recovery time, but also possess significant long-term stability. It is indicated that these ZnO nanostructures could promisingly be applied in electronic devices for environmental evaluation.
A STUDY OF SOME PECULIAR CHANGES FOUND IN THE OXONS AND DENDRITES OF THE PURKINJE CELLS

INTRODUCTION A peculiar balloon-like swelling of the dendrites of the ganglion cells was noted first by Schaffer1in amaurotic family idiocy. Later the same condition was observed in the apical dendrites of the Purkinje cells by Rogalski, Jansky, Schob, Bray, Sachs and Strauss,2Schaffer and others. This swelling of the dendrites was considered by these authors as one of the pathognomic findings of amaurotic family idiocy. In 1906, Straussler3described the same kind of alteration among the dendrites of the Purkinje cells, together with similar swellings of the axis cylinders in a psychosis—in a woman 36 years of age—which manifested certain cerebellar symptoms associated with mental agitation and intellectual weakness. The cerebellum of this patient showed congenital malformation—defect of the granular layer. He attributed this peculiar change of the dendrites to their incomplete development and overwork. In 1910, Straussler, in a report on three cases of juvenile
Fuzzy Static Output Feedback May Be Possible in LMI Framework

Takagi-Sugeno (T--S) fuzzy-model-based static output-feedback controller design is a challenging issue due to the nonconvexity in the Lyapunov stability condition. Recently, a convexified linear matrix inequality (LMI) condition was proposed for the problem by additionally importing as many equality constraints as the number of the fuzzy rules with a variable in the paper from the study of Fang et al. However, numerical experiences seem to imply the infeasibility of the proposed LMI. This letter shows that their LMI problem may be feasible.
Identification of nucleation rates in droplet-based microfluidic systems

Characterization of the rate of nucleation of crystals from solution continues to be of interest, both for investigations into fundamental molecular phenomena as well as for applications in the pharmaceuticals, biotechnology, and fine chemicals industries. Substantial experimental evidence indicates that nucleation in some solute-solvent systems does not agree with classical theory, especially at high supersaturations. An approach is proposed for computing bounds on the nucleation rate as a function of supersaturation that does not require an assumed analytical expression for the nucleation kinetics. The approach involves (1) a high-throughput microfluidic platform that measures crystal nuclei formation in droplets, (2) the analytical solution of the Chemical Master equation for nucleation that takes finite-volume effects into account, and (3) a numerical algorithm that employs linear splines to construct upper and lower bounds on the nucleation rate from the experimental data produced by the microfluidic platform. The approach is demonstrated for mean induction times measured for the nucleation of paracetamol and glycine crystals in aqueous solution, as examples in which the measured nucleation kinetics are consistent or inconsistent with classical nucleation theory, respectively. The approach can be used to suggest dependencies for the development of new nucleation expressions and for providing kinetic information needed for the simulation of crystallizers that operate at high supersaturations, such as dual-impinging-jet and vortex-mixer crystallizers.
Walking tasks encountered by urban-dwelling adults and persons with incomplete spinal cord injuries.

OBJECTIVE Gait retraining should target the walking skills most needed for independence in the home and community. The main objective of this study was to document the walking tasks most commonly encountered in daily life by able-bodied adults. The study also compared participation in walking tasks between able-bodied adults and persons with incomplete spinal cord injuries. PARTICIPANTS Convenience sample of 50 able-bodied adults and 16 ambulatory, community-dwelling persons with incomplete spinal cord injuries. METHODS A walking survey was developed, and its content validity and concurrent validity confirmed. Participants used the survey to document the frequency with which walking tasks were encountered during a full waking day. RESULTS Frequently encountered tasks included walking on smooth and rough surfaces, opening/closing doors and carrying objects. Tasks encountered more than once per day by the majority of able-bodied participants included negotiating obstacles, walking on uneven and sloped surfaces, in crowded environments, narrow spaces, and on steps and stairs. Participants with spinal cord injuries encountered fewer tasks, including many of those frequently encountered by able-bodied participants. CONCLUSION The findings identify the important walking tasks for ambulation in the home and community. These tasks should be included in therapy programs aiming to retrain functional walking.