Miracle-dz/UniFAR-FTUs huggingface dataset:
Higher Education Students' Attitudes to Student-centred Learning: Beyond 'educational bulimia'?

If education is to be truly student-centred, students should be consulted about the process of learning and teaching. Moreover, within the current higher education climate, it is imperative that institutions move from an 'inside out' approach, where those on the inside 'know' what is best, to an 'outside in' approach where customers' expectations are researched and serviced. The research reported here investigated higher education students' perceptions of and attitudes to student-centred learning. Two studies were conducted, employing the complementary methods of qualitative and quantitative data collection and analysis. The first study involved focus groups while the second involved an Internet questionnaire. Results showed that students generally held very positive views of student-centred learning. However, they were unsure as to whether current resources were adequate to support the effective implementation and maintenance of such an approach. Implications of these findings are discussed with respect to educational research and practice.
The reality of patients requiring prolonged mechanical ventilation: a multicenter study

Objective The number of patients who require prolonged mechanical ventilation increased during the last decade, which generated a large population of chronically ill patients. This study established the incidence of prolonged mechanical ventilation in four intensive care units and reported different characteristics, hospital outcomes, and the impact of costs and services of prolonged mechanical ventilation patients (mechanical ventilation dependency ≥ 21 days) compared with non-prolonged mechanical ventilation patients (mechanical ventilation dependency < 21 days). Methods This study was a multicenter cohort study of all patients who were admitted to four intensive care units. The main outcome measures were length of stay in the intensive care unit, hospital, complications during intensive care unit stay, and intensive care unit and hospital mortality. Results There were 5,287 admissions to the intensive care units during study period. Some of these patients (41.5%) needed ventilatory support (n = 2,197), and 218 of the patients met criteria for prolonged mechanical ventilation (9.9%). Some complications developed during intensive care unit stay, such as muscle weakness, pressure ulcers, bacterial nosocomial sepsis, candidemia, pulmonary embolism, and hyperactive delirium, were associated with a significantly higher risk of prolonged mechanical ventilation. Prolonged mechanical ventilation patients had a significant increase in intensive care unit mortality (absolute difference = 14.2%, p < 0.001) and hospital mortality (absolute difference = 19.1%, p < 0.001). The prolonged mechanical ventilation group spent more days in the hospital after intensive care unit discharge (26.9 ± 29.3 versus 10.3 ± 20.4 days, p < 0.001) with higher costs. Conclusion The classification of chronically critically ill patients according to the definition of prolonged mechanical ventilation adopted by our study (mechanical ventilation dependency ≥ 21 days) identified patients with a high risk for complications during intensive care unit stay, longer intensive care unit and hospital stays, high death rates, and higher costs.
Spontaneous Blinks Activate the Precuneus: Characterizing Blink-Related Oscillations Using Magnetoencephalography

Spontaneous blinking occurs 15–20 times per minute. Although blinking has often been associated with its physiological role of corneal lubrication, there is now increasing behavioral evidence suggesting that blinks are also modulated by cognitive processes such as attention and information processing. Recent low-density electroencephalography (EEG) studies have reported so-called blink-related oscillations (BROs) associated with spontaneous blinking at rest. Delta-band (0.5–4 Hz) BROs are thought to originate from the precuneus region involved in environmental monitoring and awareness, with potential clinical utility in evaluation of disorders of consciousness. However, the neural mechanisms of BROs have not been elucidated. Using magnetoencephalography (MEG), we characterized delta-band BROs in 36 healthy individuals while controlling for background brain activity. Results showed that, compared to pre-blink baseline, delta-band BROs resulted in increased global field power (p < 0.001) and time-frequency spectral power (p < 0.05) at the sensor level, peaking at ~250 ms post-blink maximum. Source localization showed that spontaneous blinks activated the bilateral precuneus (p < 0.05 FWE), and source activity within the precuneus was also consistent with sensor-space results. Crucially, these effects were only observed in the blink condition and were absent in the control condition, demonstrating that results were due to spontaneous blinks rather than as part of the inherent brain activity. The current study represents the first MEG examination of BROs. Our findings suggest that spontaneous blinks activate the precuneus regions consistent with environmental monitoring and awareness, and provide important neuroimaging support for the cognitive role of spontaneous blinks.
Pause-and-Stop: The Effects of Osmotic Stress on Cell Proliferation during Early Leaf Development in Arabidopsis and a Role for Ethylene Signaling in Cell Cycle Arrest[W]

This research assesses how plant leaf growth is regulated under water-limiting conditions at the cellular and molecular level. It demonstrates that growth and, more specifically, cell division responds to stress in a highly dynamic manner. Growth inhibition is mediated by ethylene signaling followed by adaptation and recovery. Despite its relevance for agricultural production, environmental stress-induced growth inhibition, which is responsible for significant yield reductions, is only poorly understood. Here, we investigated the molecular mechanisms underlying cell cycle inhibition in young proliferating leaves of the model plant Arabidopsis thaliana when subjected to mild osmotic stress. A detailed cellular analysis demonstrated that as soon as osmotic stress is sensed, cell cycle progression rapidly arrests, but cells are kept in a latent ambivalent state allowing a quick recovery (pause). Remarkably, cell cycle arrest coincides with an increase in 1-aminocyclopropane-1-carboxylate levels and the activation of ethylene signaling. Our work showed that ethylene acts on cell cycle progression via inhibition of cyclin-dependent kinase A activity independently of EIN3 transcriptional control. When the stress persists, cells exit the mitotic cell cycle and initiate the differentiation process (stop). This stop is reflected by early endoreduplication onset, in a process independent of ethylene. Nonetheless, the potential to partially recover the decreased cell numbers remains due to the activity of meristemoids. Together, these data present a conceptual framework to understand how environmental stress reduces plant growth.
Parenting stress and behavior among single mothers of preschoolers: The mediating role of self‐efficacy

Abstract This study examines the role of perceived self‐efficacy in mediating relations between mothers’ parenting behavior and variables such as maternal employment status, depressive symptoms, parenting stress, and child behavior problems. Subjects were 93 employed and 95 nonemployed, single, black mothers of a 3–5‐year‐old child who were current and former welfare recipients. Using linear structural relations modeling (LISREL), the findings support a model whereby (a) the more behavior problems the child is perceived to have, the more depressive symptoms the mother feels; (b) the more depressive symptoms the mother feels, the more likely she is to rate herself high in parenting stress; (c) the more depressive symptoms and parenting stress the mother experiences, the lower is the mother's estimate of her self‐efficacy; and (d) the lower the mother's self‐efficacy, the less competent is her parenting. The findings for employment status are similar; i.e., maternal employment predicted a trajectory leading to somewhat better parenting. In addition, child behavior problems were associated with less competent parenting both directly and indirectly through their effect on parenting stress and self‐efficacy. These results suggest that self‐efficacy has import as a mediator of the relations between maternal parenting and other psychosocial variables. There is no evidence, based on these findings, that employment in the low‐wage market is harmful either for single black mothers or their preschool children. However, job availability and an increase in the minimum wage are important policy considerations.
Glucocorticoid Regulation of Astrocytic Fate and Function

Glial loss in the hippocampus has been suggested as a factor in the pathogenesis of stress-related brain disorders that are characterized by dysregulated glucocorticoid (GC) secretion. However, little is known about the regulation of astrocytic fate by GC. Here, we show that astrocytes derived from the rat hippocampus undergo growth inhibition and display moderate activation of caspase 3 after exposure to GC. Importantly, the latter event, observed both in situ and in primary astrocytic cultures is not followed by either early- or late-stage apoptosis, as monitored by stage I or stage II DNA fragmentation. Thus, unlike hippocampal granule neurons, astrocytes are resistant to GC-induced apoptosis; this resistance is due to lower production of reactive oxygen species (ROS) and a greater buffering capacity against the cytotoxic actions of ROS. We also show that GC influence hippocampal cell fate by inducing the expression of astrocyte-derived growth factors implicated in the control of neural precursor cell proliferation. Together, our results suggest that GC instigate a hitherto unknown dialog between astrocytes and neural progenitors, adding a new facet to understanding how GC influence the cytoarchitecture of the hippocampus.
Inferential Beliefs in Consumer Evaluations: An Assessment of Alternative Processing Strategies

The purpose of this research is to investigate the processing strategies consumers use to form inferences about missing product information. We evaluate the relative effect of attribute information about a partially described brand and about other fully described brands, the effect of attribute intercorrelations, and the effect of prompting inferences. We find that attribute information about a partially described brand has a greater influence than that about fully described competitive brands, that highly correlated attributes more consistently influence inferences, and that prompting inferences produces substantially different results than less intrusive measures.
Cyclone: a broadcast-free dynamic instruction scheduler with selective replay

To achieve high instruction throughput, instruction schedulers must be capable of producing high-quality schedules that maximize functional unit utilization while at the same time enabling fast instruction issue logic. Many solutions exist to the scheduling problem, ranging from compile-time to run-time approaches. Compile-time solutions feature fast and simple hardware, but at the expense of conservative schedules. Dynamic schedulers produce high-quality schedules that incorporate run-time information and dependence speculation, but implementing these schedulers requires complex circuits that can slow processor clock speeds. We present the Cyclone scheduler, a novel design that captures the benefits of both compile-and run-time scheduling. Our approach utilizes a list-based single-pass instruction scheduling algorithm, implemented by hardware at run-time in the front end of the processor pipeline. Once scheduled, instructions are injected into a timed queue that orchestrates their entry into execution. To accommodate branch and load/store dependence speculation, the Cyclone scheduler supports a simple selective replay mechanism. We implement this technique by overloading instruction register forwarding to also detect instructions dependent on incorrectly scheduled operations. Detailed simulation analyses suggest that with sufficient queue width, the Cyclone scheduler can rival the instruction throughput of similarly wide monolithic dynamic schedulers. Furthermore, the circuit complexity of the Cyclone scheduler is much more favorable than a broadcast-based scheduler, as our approach requires no global control signals.
“I was Only Kidding!”: Victims’ and Perpetrators’ Perceptions of Teasing

Teasing is an interpersonal behavior that some people perceive to be fun and a matter of joking around and that other people view as cruel and a means of hurting someone’s feelings. These perspectives might reflect the views of perpetrators and victims, respectively. To examine this, 72 male and female participants wrote two narratives, one in which they described an incident when they were teased and another in which they described an event where they perpetrated the teasing. Victims and perpetrators formed very different impressions of the teasing event. Perpetrators perceived the event as more humorous and less damaging than did victims. However, they also reported feeling more guilt than did victims. Most of the incidents recounted by victims focused on physical appearance, followed by relationships and behavior. Perpetrator narratives focused primarily on behavior, followed closely by body parts and appearance. Implications of victim/perpetrator differences regarding teasing and the consequences of teasing are discussed.
Utilization of nanotechnology to enhance percutaneous absorption of acyclovir in the treatment of herpes simplex viral infections

This study aimed to formulate an optimized acyclovir (ACV) nanoemulsion hydrogel in order to provide a solution for the slow, variable, and incomplete oral drug absorption in patient suffering from herpes simplex viral infection. Solubility of ACV in different oils, surfactants, and cosurfactants was explored utilizing a cubic model mixture design to obtain a nanoemulsion with minimum globule size. Preparation of an optimized ACV nanoemulsion hydrogel using a three-factor, three-level Box–Behnken statistical design was conducted. The molecular weight of chitosan (X1), percentage of chitosan (X2), and percentage of Eugenol as a skin permeation enhancer (X3) were selected to study their effects on hydrogel spreadability (Y1) and percent ACV permeated through rat skin after 2.5 hours (Y2). A pharmacokinetic study of the optimized ACV nanoemulsion hydrogel was conducted in rats. Mixtures of clove oil and castor oil (3:1 ratio), Tween 80 and Span 80 (3:1 ratio), and propylene glycol and Myo-6V (3:1 ratio) were selected as the oil, surfactant, and cosurfactant phases, respectively. Statistical analysis indicated that the molecular weight of chitosan has a significant antagonistic effect on spreadability, but has no significant effect on the percent ACV permeated. The percentage of chitosan also has a significant antagonistic effect on the spreadability and percent ACV permeated. On the other hand, the percentage of Eugenol has a significant synergistic effect on percent ACV permeated, with no effect on spreadability. The ex vivo study demonstrated that the optimized ACV nanoemulsion hydrogel showed a twofold and 1.5-fold higher permeation percentage than the control gel and marketed cream, respectively. The relative bioavailability of the optimized ACV nanoemulsion hydrogel improved to 535.2% and 244.6% with respect to the raw ACV hydrogel and marketed cream, respectively, confirming improvement of the relative bioavailability of ACV in the formulated nanoemulsion hydrogel.
Positive emotions: passionate scholarship and student transformation

This paper challenges the practical and conceptual understanding of the role of emotions in higher education from the twin perspectives of transition and transformation. Focusing on the neglected area of positive emotions, exploratory data reveal a rich, low-level milieu of undergraduate emotional awareness in students chiefly attributed to pedagogic actions, primarily extrinsically orientated, and pervasive throughout the learning experience. The data conceive positive affect as oppositional, principally ephemeral and linked to performative pedagogic endeavours of getting, knowing and doing. A cyclical social dynamic of reciprocity, generating positive feedback loops, is highlighted. Finally we inductively construct a tentative ‘emotion-transition framework’ to assist our understanding of positive emotion as a force for transformational change; our contention is that higher education might proactively craft pedagogic spaces so as to unite the feeling discourse, the thinking discourse (epistemological self) and the wider life-self (ontological) discourse.
Household characteristics affecting drinking water quality and human health.

Pakistan’s water crisis, especially serious water shortages have had a great impact on the health of the general population. Today majority of Pakistanis have no access to improved water sources which force people to consume polluted drinking water that results in the shape of waterborne diseases. In addition to this, household characteristics, includes mother’s education and family income, also have an impact on drinking water quality and ultimately on human health. This study was conducted in three districts of Province Punjab both in urban and rural areas. The sample size of this study was 600 females of age group 20-60 years. From the data, it was concluded that mother’s education and family income were affecting drinking water quality and human health. As the mother’s years of education increased, the health issues decreased. Similarly, as the level of income increased, people suffered from water related diseases decreased.
Effect of capsinoids on energy metabolism in human subjects

Capsinoids are non-pungent compounds with molecular structures similar to capsaicin, which has accepted thermogenic properties. To assess the acute effect of a plant-derived preparation of capsinoids on energy metabolism, we determined RMR and non-protein respiratory quotient (NPRQ) after ingestion of different doses of the capsinoids. Thirteen healthy subjects received four doses of the capsinoids (1, 3, 6 and 12 mg) and placebo using a crossover, randomised, double-blind trial. After a 10 h overnight fast as inpatients, RMR was measured by indirect calorimetry for 45 min before and 120 min after ingesting capsinoids or placebo. Blood pressure and axillary temperature were measured before ( − 55 and − 5 min) and after (60 and 120 min) dosing. Before dosing, mean RMR was 6247 (se 92) kJ/d and NPRQ was 0·86 (se 0·01). At 120 min after dosing, metabolic rate and NPRQ remained similar across the four capsinoids and placebo doses. Capsinoids also had no influence on blood pressure or axillary temperature. Capsinoids provided in four doses did not affect metabolic rate and fuel partitioning in human subjects when measured 2 h after exposure. Longer exposure and higher capsinoids doses may be required to cause meaningful acute effects on energy metabolism.
The Roles of Attitudinal and Personality Variables in the Prediction of Environmental Behavior and Knowledge

The success of environmental policies and action programs may well depend upon an understanding of the impact of intraindividual variables on responses to environmental problems. A survey designed to assess environmental behavior, attitudes, and knowledge, as well as several personality dimensions, was administered to two diverse samples: 85 users of a recycling center and 60 conservative church members. The two samples differed systematically as predicted on behavior, attitude, knowledge, and personality characteristics. Stepwise multiple regression analyses (with a third sample of 69 students added) revealed that education, knowledge, and environmentally related attitudes best predicted recycling behavior, while exposure to information through books, personality, and attitudes best predicted environmental knowledge. Implications are drawn for environmental action programs.
Differences in the Occupational Achievement Process between Male and Female College Graduates.

In the college graduating class of 1961, mean 1968 occupational achievement for men and women was similar. The standard deviation for men was greater than that for women, indicating that occupational opportunities of women were more constricted than were those of men. Basically the same pattern holds for occupational expectations held in the freshman and senior years in college and three years after graduation. On the other hand, women's achievement of education beyond the bachelor's degree lagged behind men's. Regression analysis reveals that compared with men, women showed greater instability in occupational expectations, reaped lesser returns in occupational status from investments in advanced education, and were less likely to realize their occupational expectations.
A Non-Randomized Multicentre Trial of Human Immune Plasma for Treatment of Hantavirus Cardiopulmonary Syndrome Caused by Andes Virus

Background In Chile, Andes virus (ANDV) is the sole aetiological agent of hantavirus cardiopulmonary syndrome (HCPS) with mean annual incidence of 55 cases, 32% case fatality rate (CFR) and no specific treatment. Neutralizing antibody (NAb) titres at hospital admission correlate inversely with HCPS severity. We designed an open trial to explore safety and efficacy and evaluate pharmacokinetics of immune plasma as a treatment strategy for this disease. Methods We performed plasmapheresis on donors at least 6 months after HCPS and measured NAb titres through a focus-reduction neutralization test. Subjects admitted to 10 study sites with suspected/confirmed HCPS were eligible for treatment with immune plasma by intravenous infusion at an ANDV NAb dose of 5,000 U/kg. HCPS was confirmed through immunoglobulin M serology or reverse transcriptase-PCR. The main outcome was mortality within 30 days. Results From 2008–2012, we enrolled and treated 32 cases and confirmed HCPS in 29. CFR of hantavirus plasma-treated cases was 4/29 (14%); CFR of non-treated cases in the same period in Chile was 63/199 (32%; P=0.049, OR=0.35, CI=0.12, 0.99); CFR of non-treated cases at the same study sites between 2005–2012 was 18/66 (27%; (P=0.15, OR=0.43, CI=0.14, 1.34) and CFR in a previous methylprednisolone treatment study was 20/60 (33%; P=0.052, OR=0.32, CI=0.10, 1.00). We detected no serious adverse events associated to plasma infusion. Plasma NAb titres reached in recipients were variable and viral load remained stable. Conclusions Human ANDV immune plasma infusion appears safe for HCPS. We observed a decrease in CFR in treated cases with borderline significance that will require further studies for confirmation.
The End of Certainty? The Academic Profession and the Challenge of Change

Pour introduire ce numero special sur les enseignants universitaires, l'auteur dresse le bilan des enjeux pour cette profession au tournant du siecle. Le principal defi de l'enseignement universitaire est en effet celui de la mise en cause du savoir sous sa forme traditionnelle : le post-modernisme a serieusement entame les a priori conventionnels sur le savoir et les disciplines d'enseignement se transforment en elargissant leurs champs d'interet ; la societe de l'information et les nouvelles technologies modifient la pedagogie universitaire (pedagogie virtuelle, formation tout au long de la vie) ; l'enseignement superieur de masse cree de nouvelles priorites quant au contenu d'enseignement ; la pression economique modifie les prises de decision administratives qui visent l'efficacite tandis que les salaires des enseignants baissent ; l'experience internationale des enseignants est tres valorisee ce qui renforce la discrimination a l'egard des femmes et la prevalence des echanges entre les blocs Amerique, Asie et Europe. Au bout du compte, l'auteur souligne l'importance de relever ces defis pour le corps enseignant universitaire car il s'agit de maintenir le cap de la democratie qui est la voie du bien social.