Miracle-dz/UniFAR-FTUs huggingface dataset:
The Expression of the SWI/SNF ATPase Subunits BRG1 and BRM in Normal Human Tissues

SWI/SNF is a chromatin-remodeling complex important in gene regulation, cytokine responses, tumorigenesis, differentiation, and development. As a multitude of signaling pathways require SWI/SNF, loss of SWI/SNF function is expected to have an impact on cellular phenotypes. The SWI/SNF ATPase subunits, BRG1 and BRM, have been shown to be lost in a subset of human cancer cell lines and human primary cancers and may represent tumor suppressor proteins. To better understand the biology of these proteins, the authors examined the expression pattern of BRG1 and BRM in a variety of normal tissues. BRG1 expression was predominantly seen in cell types that constantly undergo proliferation or self-renewal; in contrast, BRM was preferentially expressed in brain, liver, fibromuscular stroma, and endothelial cell types, cell types not constantly engaged in proliferation or self-renewal. This differential expression suggests that these proteins serve distinct functions in human tissues.
LED illumination for video‐enhanced DIC imaging of single microtubules

In many applications high‐resolution video‐enhanced differential interference contrast microscopy is used to visualize and track the ends of single microtubules. We show that single ultrabright light emitting diodes from Luxeon can be used to replace conventional light sources for these kinds of applications without loss of function. We measured the signal‐to‐noise ratio of microtubules imaged with three different light emitting diode colours (blue, red, green). The blue light emitting diode performed best, and the signal‐to‐noise ratios were high enough to automatically track the ends of dynamic microtubules. Light emitting diodes as light sources for video‐enhanced differential interference contrast microscopy are high performing, low‐cost and easy to align alternatives to existing illumination solutions.
Leprosy: dental and periodontal status of the anterior maxilla in 76 patients.

OBJECTIVE To evaluate the presence of oral disease, as assessed by dental and periodontal indices, in the anterior maxilla of a group of 76 patients with leprosy, compared with a group of matched control subjects. MATERIALS AND METHODS The study included 76 patients with leprosy (age range 40-82 years; 39 males), resident in the sanatorium of San Francisco de Borja de Fontilles (Alicante, Spain). Clinical examination was carried out to evaluate the decayed missing and filled index, and the periodontal status in the anterior maxilla, using the Löe-Silness dental plaque index, mean periodontal probing depth and the average periodontal attachment loss. RESULTS In the leprosy patients, a large proportion of maxillary incisors and canines were missing. The mean plaque index in leprosy was 2.35 +/- 0.7, with a probing depth of 2.96 +/- 0.8, and an average attachment loss of 4.18 +/- 1.3, indices all statistically greater than in controls. There were no differences detected in the oral indices measured according to the presence or absence of facial destruction or the type of leprosy. CONCLUSIONS Patients with leprosy show a tendency to poor dental and periodontal health, unrelated to the presence of facial destruction or the type of leprosy.
Listening to Girls and Boys Talk About Girls’ Physical Activity Behaviors

As part of the formative assessment for the Trial of Activity for Adolescent Girls (TAAG), a multicenter study to reduce the decline of physical activity in adolescent girls, girls and boys with diverse ethnicity from six states participated in focus groups and semistructured interviews. Data from 13 girls’ focus groups (N = 100), 11 boys’ focus groups (N = 77), and 80 semistructured interviews with girls are examined to identify perceptions of girls’ physical activity behaviors to help develop TAAG interventions. Both girls and boys talk about physically active girls as being “tomboys” or “too aggressive. ” Girls are more likely to characterize active girls as “in shape,” whereas boys say they are “too athletic. ” Girls report boys to be influential barriers and motivators in shaping their beliefs about physical activity. Given the strong influence of peers, developing successful interventions for girls should include verbal persuasion, modeling, and social support from both girls and boys.
Transoral Robotic versus Open Surgical Approaches to Oropharyngeal Squamous Cell Carcinoma by Human Papillomavirus Status

Objectives (1) Investigate oncologic survival outcomes and (2) analyze the impact of human papillomavirus status on prognosis in patients with oropharyngeal squamous cell carcinoma treated with transoral robotic versus open surgery. Study Design Retrospective cohort study. Setting Tertiary care referral center, University of Alabama at Birmingham Hospital. Subjects One hundred thirty total (65 per treatment arm) with primary oropharyngeal squamous cell carcinoma (OPSCC). Methods Patients treated for primary oropharyngeal squamous cell carcinoma with either transoral robotic (TORS) or open surgery plus standard of care adjuvant therapy between October 2004 and March 2012 were matched based on TNM staging before a retrospective chart review was performed. Carcinoma tissue was stained both prospectively and retrospectively with CINtec p16-INK4a kits for surrogate human papillomavirus typing. Recurrence-free survival was used to evaluate the impact of human papillomavirus tumor status and method of surgical intervention on prognosis. Results As a whole, patients treated with transoral robotic surgery survived more frequently (94%, 91%, 89% at 1, 2, 3 years, respectively) than those treated with open surgery (85%, 75%, 73% at 1, 2, 3 years, correspondingly) (P = .035). The subgroup of patients with human papillomavirus-negative malignancies treated with open surgery survived without recurrence less frequently at 1, 2, and 3 year rates of 58%, 25%, 25%, respectively (P < .01). Conclusion These retrospective data suggest that oncologic outcomes are not being sacrificed when patients with OPSCC are treated with TORS instead of open surgery regardless of tumor human papillomavirus immunohistochemical staining.
The growth of twins between the ages of 2 and 9 years

Background: Twin growth studies are mostly based on pooled data without consideration of zygosity, parental heights or birth weight. Aim: The study investigated the effects of gender, zygosity, parental height and birth weight on subsequent twin growth. Methods: Height and weight measurements of 1533 twins (n = 1077 for occipito-frontal head circumference (OFC)), age range 2–9 years, were converted to standard deviation scores derived from singleton standards. Their growth was evaluated in relation to gender, zygosity, parental heights and birth weight. Results: Mean stature of twins fell only slightly below the reference values of singletons, but they were underweight to a greater extent (boys more than girls). Twins’ OFC were low (girls more so than boys). Monozygotic (MZ) twin boys were lighter and shorter than dizygotic twins and MZ twin girls. Deficient growth was most evident in those babies light at birth. Parental heights only partly accounted for the difference in height of twins. Conclusions: Birth weight and parental height are important in relation to subsequent growth. Boy twins are at a disadvantage compared with girls in terms of their growth in height and weight, particularly in the low birth weight and MZ groups.
Risk factors for delayed bleeding from endoscopic submucosal dissection of gastric neoplasms

Abstract Objective. Delayed bleeding is a major complication of endoscopic submucosal dissection (ESD) of gastric neoplasms. We aimed to clarify risk factors for delayed bleeding from ESD. Material and methods. This study included 447 patients in whom 544 gastric neoplasms were resected by ESD between April 2006 and March 2011 in Yamaguchi University Hospital. We analyzed risk factors for delayed bleeding from ESD in relation to various clinical and pathological factors. Results. En bloc resection rate was 95.4% (519/544), and curative resection rate was 87.8% (477/544). Delayed bleeding occurred in 7.0% (38/544) and perforation occurred in 1.8% (10/544) of patients. Univariate analysis revealed platelet count (Plt) <15 × 104/μl (p = 0.013), prothrombin time (PT) <70% (p = 0.044), resected size ≥50 mm (p = 0.038), and positive/indeterminate lateral margin (p = 0.012) to be risk factors for delayed bleeding. Multivariate analysis showed that Plt <15 × 104/μl (odds ratio [OR], 2.62; 95% confidence interval [CI]: 1.17–5.53, p = 0.020) and positive/indeterminate lateral margin (OR, 5.45; 95% CI: 1.39–17.95, p = 0.018) were independent risk factors for delayed bleeding. Conclusions. Low Plt, low PT, large resected size, and positive/indeterminate lateral margin were significant risk factors for delayed bleeding from ESD. Patients with these risk factors must be carefully observed for signs of delayed bleeding.
Concomitant Urothelial Cancer and Renal Tuberculosis

We report a case of coexisting urothelial cancer and renal tuberculosis in the same kidney. The patient is a 72-year-old female with a remote history of treated pulmonary tuberculosis who presented with haematuria, initial investigation of which elucidated no definitive cause. Almost 1 year later, a diagnosis of metastatic urinary tract cancer was made. The patient received chemotherapy for advanced collecting duct type renal cell carcinoma, based on histological features of renal biopsy. Subsequent confirmatory immunostains however led to a revised diagnosis of urothelial cancer, necessitating a change in chemotherapy regimen. A diagnosis of ipsilateral renal tuberculosis was made based on TB-PCR testing of renal biopsy tissue and anti-TB therapy was coadministered with chemotherapy. The patient died 9 months after diagnosis of metastatic urothelial cancer.
A Fast Heuristic Algorithm for Similarity Search in Large DNA Databases

Knowledge Discovery techniques seek to find new information about a domain. These techniques can either be manually performed by an expert, or automated using software algorithms (Machine Learning). However some domains (such as the field of lung function testing) contain volumes of data too vast for effective manual analysis, and require background knowledge too complex for Machine Learning algorithms. This study examines how the Multiple Classification Ripple-Down Rules (MCRDR) Knowledge Acquisition process can be adapted to develop a new Knowledge Discovery method, Exposed MCRDR. A prototype system was developed and tested in the domain of lung function. Preliminary results suggest that the EMCRDR method can be successfully applied to efficiently discover new knowledge in a complex domain. The study also reveals many potential areas of study and development for the MCRDR method, and Knowledge Acquisition and Knowledge Discovery methods in general.
A SURVEY ON OCCUPATIONAL ACCIDENTS AMONG CONSTRUCTION INDUSTRY WORKERS IN YAZD CITY: APPLYING TIME SERIES 2006-2011

Received: September 2011, Accepted: October 2011 Background: Millions of construction industry accidents occur in the world causing demages and injuries to workers and consequently economical losses every year. The aim of this study was to determine an estimator model for accidents among construction industry workers, in the years 2006 2011 for the first time, in Yazd city. Materials and Methods: In this descriptive study, the questionnaire included items asking about variables such as age, occupation, type of accident, injured organ and the outcome of the accident. Time Series Model was used in this study to estimate accidents among the Yazd construction workers up to 2011. Results: Fatality rate of workers who did not have insurance was more than those who had, which was statistically significant (p < 0.001). The greatest rate of accident was falling (48.58%) and the lowest was chocking (29%). The relationships of accident outcomes with type of occupation and also the injured part of body were statistically significant in the construction industry (p<0.001). After testing many models, time series model of quadratic form was the closest model to the trend of data. Conclusions: This model estimation shows that if the situation is the same as now in 2011 the accident cases will be more than 300 per year in 2012 and later. So this model is recommended to make changes in the trend for preventing the accidents in the future.
Relationship of Personality Trait Impulsivity with Clinical Variables in Male Alcohol-Dependent Inpatients

Impulsivity is an important clinical problem in psychiatry (1). Among psychiatric diagnoses, impulsivity is more common in subjects with conduct disorders, attention deficit hyperactivity disorder, disorders of personality, substance and alcohol abuse, psychotic disorders, bipolar disorders, eating disorders and dementia compared to healthy control groups (2). The manifestation of impulsivity in these different syndromes may be different, and this has led to conflicting definitions (1). Being a measurable feature of behavior, impulsivity is defined as the failure to resist a drive or stimulus or as a personality dimension as the inability to resist the desire Relationship of Personality Trait Impulsivity with Clinical Variables in Male Alcohol-Dependent Inpatients
A Failed Gamma-Ray Burst with Dirty Energetic Jets Spirited Away? New Implications for the Gamma-Ray Burst-Supernova Connection from SN 2002ap

The Type Ic supernova (SN) 2002ap is an interesting event with very broad spectral features like the famous energetic SN 1998bw associated with a gamma-ray burst (GRB) 980425. Here we examine the jet hypothesis from SN 2002ap recently proposed based on the redshifted polarized continuum found in a spectropolarimetric observation. We show that jets should be moving at about 0.23c to a direction roughly perpendicular to us, and the degree of polarization requires a jet kinetic energy of at least 5 × 1050 ergs, a similar energy scale to the GRB jets. The weak radio emission from SN 2002ap has been used to argue against the jet hypothesis, but we argue that this is not a problem because the jet is expected to be freely expanding and unshocked. However, the jet cannot be kept ionized because of adiabatic cooling without external photoionization or a heating source. We explored various ionization possibilities and found that only the radioactivity of 56Ni is a plausible source, indicating that the jet is formed and ejected from the central region of the core collapse, not from the outer envelope of the exploding star. Then we point out that, if the jet hypothesis is true, the jet will eventually sweep up enough interstellar medium and generate shocks in a few to 10 yr, producing strong radio emission that can be spatially resolved, giving us a clear test for the jet hypothesis. Discussions are also given on what the jet would imply for the GRB-SN connection, when it is confirmed. We suggest the existence of two distinct classes of GRBs from similar core-collapse events but by completely different mechanisms. Cosmologically distant GRBs having an energy scale of ~1050-1051 ergs are collimated jets generated by the central activity of core collapses, associated with 56Ni ejection along with the jets. SN 2002ap can be considered as a failed GRB of this type with large baryon contamination. On the other hand, much less energetic ones including GRB 980425 are rather isotropic, which may be produced by hydrodynamical shock acceleration at the outer envelope. We propose that the radioactive ionization for the SN 2002ap jet may give a new explanation also for the X-ray line features often observed in GRB afterglows.
Overview of the ICDAR 2013 Competition on Book Structure Extraction

Abstract--This paper summarizes the 3rd Book Structure Extraction competition that was run at the ICDAR 2013. Its goal is to evaluate and compare automatic techniques for deriving structure information from digitized books, which could then be used to aid navigation inside the books. More specifically, the task that participants are faced with is to construct hyperlinked tables of contents for a collection of 1,000 digitized books. This paper reviews the setup of the competition, the book collection used in the task, and the measures used for the evaluation. The main novelty of the 2013 competition is that we were able to rely on an external provider for the ground truthing phase, hence granting the consistency of the evaluation. In addition, this allowed us to nearly double the number of annotated books from the 1,040 books annotated in 2009 and 2011 to over 2,000 books. The paper further presents the resulting performance of the 6 participating research teams, and briefly summarizes their approaches.
Efficiently adapting to sharing patterns in software DSMs

In this paper we introduce a page-based Lazy Release Consistency protocol called ADSM that constantly and efficiently adapts to the applications' sharing patterns. Adaptation in ADSM is based on our dynamic categorization of the type of sharing experienced by each page. Pages can be categorized as falsely-shared, migratory, or producer/consumer(s). Migratory and producer/consumer(s) pages are managed in single-writer mode, while falsely-shared data are managed in multiple-writer mode. Coherence is kept with invalidations for most types of the shared data, but updates are used for lock-protected data in migratory state and barrier-protected delta in producer/consumer(s) state. We performed experiments with 6 parallel applications on an 8-node SP2 system, comparing our protocol against standard TreadMarks and a version of TreadMarks that also adapts to sharing patterns. Our results show that ADSM consistently outperforms its competitors; our protocol can improve the TreadMarks speedups by as much as 155%, while surpassing the performance of the adaptive TreadMarks implementation by as much as 67%. Our main conclusions are that our categorization and adaptation strategies are useful techniques for improving the performance of page-based software DSMs, while ADSM is a highly-efficient option for low-cost parallel computing.
Simple heuristics for unit disk graphs

Unit disk graphs are intersection graphs of circles of unit radius in the plane. We present simple and provably good heuristics for a number of classical NP-hard optimization problems on unit disk graphs. The problems considered include maximum independent set, minimum vertex cover, minimum coloring and minimum dominating set. We also present an on-line coloring heuristic which achieves a competitive ratio of 6 for unit disk graphs. Our heuristics do not need a geometric representation of unit disk graphs. Geometric representations are used only in establishing the performance guarantees of the heuristics. Several of our approximation algorithms can be extended to intersection graphs of circles of arbitrary radii in the plane, intersection graphs of regular polygons, and to intersection graphs of higher dimensional regular objects.
Untargeted NMR Spectroscopic Analysis of the Metabolic Variety of New Apple Cultivars

Metabolome analyses by NMR spectroscopy can be used in quality control by generating unique fingerprints of different species. Hundreds of components and their variation between different samples can be analyzed in a few minutes/hours with high accuracy and low cost of sample preparation. Here, apple peel and pulp extracts of a variety of apple cultivars were studied to assess their suitability to discriminate between the different varieties. The cultivars comprised mainly newly bred varieties or ones that were brought onto the market in recent years. Multivariate analyses of peel and pulp extracts were able to unambiguously identify all cultivars, with peel extracts showing a higher discriminative power. The latter was increased if the highly concentrated sugar metabolites were omitted from the analysis. Whereas sugar concentrations lay within a narrow range, polyphenols, discussed as potential health promoting substances, and acids varied remarkably between the cultivars.
Using Automated On-Site Monitoring to Calibrate Empirical Models of Trihalomethanes Concentrations in Drinking Water

An automated, on-site trihalomethanes concentration data set from a conventional water treatment plant was used to optimize powdered activated carbon and pre-chlorination doses. The trihalomethanes concentration data set was used with commonly monitored water quality parameters to improve an empirical model of trihalomethanes formation. A calibrated model was used to predict trihalomethanes concentrations the following year. The agreement between the models and measurements was evaluated. The original model predicted trihalomethanes concentrations within ~10 μg·L−1 of the measurement. Calibration improved model prediction by a factor of three to five times better than the literature model.
Test Anxiety and Psychopathology in Fifth-Grade Students in Turkey

Thirty-four to 41% of third through sixth-grade children suffer from test anxiety (Beidel, 1991; Turner, Beidel, Hughes, & Turner, 1993). In surveying large samples (Gallagher & Miller, 1996; Kyriacou & Butcher, 1993), assessments of the school subjects and exams were found to be major stressors for the children. In its most extreme form, test anxiety can even be a contributing factor to school refusal (Ollendick & Meyer, 1984). Empirical studies show that test anxiety is a major debilitating factor on all academic levels, from elementary to higher education (Sarason, 1984). Therefore, test anxiety is one of the important issues arousing interest in educators, counselors, psychologists, and researchers. In general, test anxiety is a form of trait anxiety (McDonald, 2001; Öner, 1990; Peleg-Popko & Klingman, 2002; Sieber, 1980). Test anxiety is a multidimensional concept in terms of both development and outcome. Quite a few researchers (Hedl, 1972; Sarason, 1975; Spielberger, 1972; Trent & Maxwell, 1980) consider test anxiety as a relatively stabilized personality trait. This trait appears to be a reaction toward assessment experiences of the children. A high level of evaluation anxiety is a result of a child’s inability to reach high and unreal academic achievement and performance expectations of the parents (Dusek, 1980). Children frequently encounter exams throughout their educational period. Accomplishment at school and parents’ pressure are internalized and turn into behaviors to meet the demands of the parents. When there is no adult support and no response for the demand of parents’ high academic achievement, the child develops an avoidance reaction in such evaluative situations and feels anxious. Test anxiety is a major factor contributing to a variety of negative outcomes including psychological distress, academic underachievement, academic failure, and insecurity (Hembree, 1988). Most of the research related to test anxiety has been done on the relationship between test anxiety and academic achievement and the possible effects on academic achievement. In general, research findings indicate that there is a significant negative relationship between test anxiety and academic achievement/performance (Akbağ 1995; Araki, Iwawaki, & Spielberger, 1992; Campbell, 1986; Erkan, 1991; Hembree, 1988; Öner, 1990; Zattz & Chassin, 1985). The relationship between