Miracle-dz/UniFAR-FTUs huggingface dataset:
Toward an Insider Threat Detection Framework Using Honey Permissions

The insider threat remains one of the most serious challenges to computer security. An insider attack occurs when an authorized user misuses his privileges and causes damages to the organization. Deception techniques have served as a common solution to insider threat detection, and several techniques, such as approaches based on honey entities, have been proposed. On the other hand, access control systems lack the ability to detect insider threats. In this paper, we focus on integrating deception into the role-based access control (RBAC) model, which is one of the most widely used access control models. We introduce the notion of “honey permission” and use it to extend RBAC to help in insider threat detection. We define honey permissions as permissions that exceed the authorized access, and are assigned to a subset of roles known as “candidate roles”. Objects included in honey permissions are fake versions of sensitive objects that are enticing for malicious users. In this way, an attempt to access sensitive resources by unauthorized users would be detected. We extend the RBAC model by adding honey permissions, indicating candidate roles, and adding a monitoring unit which monitors the sessions in which the owners of the sessions activate a subset of candidate roles and have access to an object through a honey permission. We propose an algorithm to select candidate roles and assign honey permissions to them. Furthermore, we provide security analysis and consider the overhead that would be added to the RBAC system for evaluation.
Dietary Heterocyclic Amine Intake, NAT2 Genetic Polymorphism, and Colorectal Adenoma Risk: The Colorectal Adenoma Study in Tokyo

Background: While several studies have provided support for a positive association between meat intake and colorectal neoplasia, the role of heterocyclic amines (HCA), which is hypothesized to underline this relation, has been less consistent. We evaluated the association of HCA intake with colorectal adenoma risk in a case–control study in a middle-aged Japanese population. Methods: Study subjects were 738 patients with adenoma and 697 controls who underwent total colonoscopy between 2004 and 2005 and responded to self-administered lifestyle and dietary questionnaires. HCA exposure concentration was estimated from meat and fish intake based on an HCA database that was validated against 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) values measured in human hair. Logistic regression models were used to estimate ORs and 95% confidence interval (CI) for the association between HCA and colorectal adenoma risk after adjusting for potential confounders. Results: High intake of 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ) and total HCA was associated with an increased risk of colorectal adenoma in women but not in men. The multivariate-adjusted OR for the highest versus lowest quartile in women was 2.10 (95% CI, 1.20–3.67; Ptrend = 0.01) for MeIQ and 1.73 (95% CI, 0.99–3.01; Ptrend = 0.03) for total HCA. No clear association with PhIP or 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) estimates and no effect modification by NAT2 acetylation genotype was observed. Conclusions: This study suggests that high MeIQ and total HCA estimates are positively associated with colorectal adenoma risk. Impact: The findings add to evidence that HCA may play a role in colorectal carcinogenesis in humans. Cancer Epidemiol Biomarkers Prev; 24(3); 613–20. ©2015 AACR.
A Translational Murine Model of Sub-Lethal Intoxication with Shiga Toxin 2 Reveals Novel Ultrastructural Findings in the Brain Striatum

Infection by Shiga toxin-producing Escherichia coli causes hemorrhagic colitis, hemolytic uremic syndrome (HUS), acute renal failure, and also central nervous system complications in around 30% of the children affected. Besides, neurological deficits are one of the most unrepairable and untreatable outcomes of HUS. Study of the striatum is relevant because basal ganglia are one of the brain areas most commonly affected in patients that have suffered from HUS and since the deleterious effects of a sub-lethal dose of Shiga toxin have never been studied in the striatum, the purpose of this study was to attempt to simulate an infection by Shiga toxin-producing E. coli in a murine model. To this end, intravenous administration of a sub-lethal dose of Shiga toxin 2 (0.5 ηg per mouse) was used and the correlation between neurological manifestations and ultrastructural changes in striatal brain cells was studied in detail. Neurological manifestations included significant motor behavior abnormalities in spontaneous motor activity, gait, pelvic elevation and hind limb activity eight days after administration of the toxin. Transmission electron microscopy revealed that the toxin caused early perivascular edema two days after administration, as well as significant damage in astrocytes four days after administration and significant damage in neurons and oligodendrocytes eight days after administration. Interrupted synapses and mast cell extravasation were also found eight days after administration of the toxin. We thus conclude that the chronological order of events observed in the striatum could explain the neurological disorders found eight days after administration of the toxin.
Post‐Traumatic Parotid Fistulae and Sialoceles. A Prospective Study of Conservative Management in 51 Cases

The management of parotid sialoceles and fistulae have been unsatisfactory in the past, and numerous methods of treatment with varying success and morbidity have been described. The present prospective study reports results of conservative therapy in 51 patients over a 3-year period. In 50 patients, the injury healed upon conservative management. During the early phase of the study, a limited conservative regimen through which the patients received nothing orally for 5 days only was used. During the latter part of the study, patients were administered nothing orally until complete healing of the injury. In terms of the time it took for healing of the injury, the differences of the two regimens (24 ± 4 vs. 9.4 ± 0.9 days) was highly significant (p < 0.001). The response to conservative management depended on the severity of injury as demonstrated by sialography. Injury to minor intraparotid ducts (Gl) healed in significantly less time compared with that to a major intraparotid duct (G2) or ductal injuries (p < 0.001). There was no difference between the healing of G2 injury (10.3 ±1.8 days) and partial ductal transections (10.5 ± 2.2 days) (p > 0.05). There was a significantly greater delay in healing with complete duct transections (21.5 ± 3.7 days) compared with partial duct transections and G2 injuries (10.2 ± 2.1 days) (p < 0.01). There was no difference in the mean period for healing between salivary fistulae and sialoceles (p > 0.05). It is concluded that a new classification of parotid fistulae based on sialographic findings has prognostic and therapeutic value. Furthermore, the excellent results achieved with conservative therapy in this study suggest that it may be the initial treatment of choice for parotid fistulae.
Observed and modeled larval settlement of a reef fish to the Florida Keys

The bipartite life history of most marine organisms leads to complex patterns of replenishment in benthic populations. High variation in adult spawning, dynamic oceanographic currents, and often unknown larval behaviors create challenges in accurately predicting spatial and temporal patterns in the supply and settlement of pelagic larvae to nearshore juvenile habi- tats. Yet, understanding and predicting larval exchange underlies population dynamics, ecologi- cal interactions, and conservation practices. We compared observed patterns of larval settlement of the bicolor damselfish Stegastes partitus (Pomacentridae) along the Florida Keys, USA, to those obtained through model simulations using a high-resolution biophysical model parameterized with species-specific early life-history information. Light traps intercepted settlement-stage lar- vae, and divers censused new recruits at 2 replicate reefs in each of the upper (eastern) (UK) and lower (western) Keys (LK) during 6 peak settlement periods. Damselfish settlement and recruit- ment to the LK consistently exceeded that to the UK. Remarkably, model simulations successfully explained 70% of temporal variation in settlement within each region. However, the model did not capture the relative magnitude of observed settlement between the regions: settlement was either overestimated in the UK or underestimated in the LK. Potential causes include weak larval settle- ment cues or larval ability to navigate and swim to settlement habitat in the UK, higher larval con- dition and survival in the more productive waters of the LK, or substantial spatial variation in reproductive output. Connectivity matrices indicate that a majority of S. partitus settlement to the Florida Keys is sourced from Keys populations.
Obstetric aspects of the Prader–Willi syndrome

The Prader–Willi syndrome (PWS) is a complex, multisystem disorder. The syndrome affects the central nervous system, with a predilection for the hypothalamus. The clinical picture in PWS is very variable, and depends on the age of the affected child. Frequently, the most prominent features such as obesity, mental retardation and behavioral disorders do not become evident until the later childhood stage, which can lead to underdiagnosis or late diagnosis in early childhood. Because of the long‐term implications of this syndrome, it is important to recognize its features as soon as possible so that early counseling of parents and the affected child is possible. Because PWS can also lead to complications in both pregnancy and labor, proper diagnosis in the fetus can also help optimize perinatal care in affected children. In three cases we illustrate that certain combinations of obstetric symptoms such as polyhydramnios, diminished fetal movements, malpresentation and abnormal fetal heart rhythm can help alert clinicians to the possibility of this syndrome in fetuses. Copyright © 2003 ISUOG. Published by John Wiley & Sons, Ltd.
Efficacy of VP2 protein expressed in E. coli for protection against highly virulent infectious bursal disease virus

The ability of a heat-inactivated whole virus from a highly virulent infectious bursal disease virus (hvIBDV) and VP2 protein from hvIBDV expressed in E. coli provided protection against a hvIBDV challenge in specific-pathogen-free (SPF) chickens. Six out of seven chickens that were injected three times with crude VP2 protein developed significant antibody titer against IBDV. However, only four out of the seven chickens survived the hvIBDV challenge. Despite showing low antibody titer profiles, all chickens immunized with the heat-inactivated whole virus also survived the challenged with hvIBDV. However, all of these chickens had bursal atrophy and mild to moderate depletion of lymphocytes. Thus, antibodies raised against IBDV VP2 protein expressed in E. coli and denatured IBDV proteins induced some degree of protection against mortality but not against bursal damage following challenge with hvIBDV.
Neonatal age and period of estrogen exposure affect porcine uterine growth, morphogenesis, and protein synthesis.

To determine whether neonatal age and estrogen exposure affect uterine growth, morphogenesis, and protein synthesis, crossbred gilts were randomly assigned at birth (Day 0) to receive either corn oil vehicle (CO) or estradiol-17 beta valerate (EV; 50 micrograms/kg BW/day). Gilts were treated for 7 days, chosen to coincide with specific periods of uterine development, prior to hysterectomy on Day 7, 14, or 49. Uteri were weighed, and tissues were fixed for histology or explanted with L-4,5-[3H]leucine (3H-leu) for 24 h. Endometrial and myometrial thicknesses were measured in uterine wall cross sections. Radiolabeled proteins produced by uterine wall tissues from 3H-leu and released into explant medium were identified by fluorography of two-dimensional SDS-PAGE gels. Proteins for which fluorographic spot intensities were consistently affected by age and/or treatment were excised from gels, and associated radioactivity was quantified. Normal growth and histogenesis were observed in uteri from CO-treated gilts. Exposure to EV increased (p < 0.01) uterine wet weight on all days examined, although effects were most pronounced on Day 49 (day x treatment, p < 0.01). Histologically, uteri of EV-treated gilts exhibited precocious or altered patterns of development of endometrial glands and folds. Endometrial thickness was greater (p < 0.01) in EV-treated gilts, and response was most pronounced on Day 49 (day x treatment, p < 0.01). Treatment with EV increased (p < 0.01) myometrial thickness on Day 49 only. Twenty-five uterine proteins were identified to be affected consistently by neonatal age, EV, or both. Production of four of these proteins was affected by age alone, while six were affected exclusively by treatment with EV alone, and 15 were affected differentially by both age and EV. Treatment with EV affected production of three of these 25 proteins on Day 7, 8 of 25 on Day 14, and 14 of 25 on Day 49. Results indicate that uterine growth and development of the porcine uterine wall during early neonatal life are accompanied by predictable alterations in patterns of uterine protein synthesis. Data also demonstrate that the neonatal porcine uterus is estrogen-sensitive and that both physical and biochemical responses of uterine tissues to estrogen vary with period of exposure. It is suggested that EV may be useful as a tool with which to induce developmental lesions in neonatal porcine uterine tissues. (ABSTRACT TRUNCATED AT 400 WORDS)
Measures of Adiposity and Risk of Stroke in China: A Result from the Kailuan Study

Objective The objective of this study was to explore the association between adiposity and risk of incident stroke among men and women. Methods We studied the relationship between adiposity and stroke among 94,744 participants (18–98 years old) in the Kailuan study. During a follow-up of 4 years, 1,547 ischemic or hemorrhagic strokes were recorded. Measurements of adiposity included body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHpR), and waist-to-height ratio (WHtR). Hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated from Cox regression models and each model fit was assessed using −2log-likelihood. Results Every measurement of adiposity was associated with the risk for total stroke and ischemic stroke, but not for hemorrhagic stroke. After adjusting for confounders and intermediates, the HR (comparing the mean of the highest quintile with that of the lowest quintile) for total stroke was 1.34(1.13–1.60) for BMI, 1.26(1.06–1.52) for WC, 1.29(1.08–1.56) for WHpR, and 1.38(1.15–1.66) for WHtR. The HR for ischemic stroke was 1.52(1.24–1.88) for BMI, 1.46(1.17–1.81) for WC, 1.40(1.12–1.74) for WHpR, and 1.62(1.29–2.04) for WHtR. The model fit for each of the indices was similar. Conclusions Adiposity increases the total risk of stroke and ischemic stroke, but not of hemorrhagic stroke. No clinically meaningful differences among the associations between BMI, WC, WHpR, and WHtR and stroke incidence were identified in this study.
Abscisic acid enhances tolerance of wheat seedlings to drought and regulates transcript levels of genes encoding ascorbate-glutathione biosynthesis

Glutathione (GSH) and ascorbate (ASA) are associated with the abscisic acid (ABA)-induced abiotic tolerance in higher plant, however, its molecular mechanism remains obscure. In this study, exogenous application (10 μM) of ABA significantly increased the tolerance of seedlings of common wheat (Triticum aestivum L.) suffering from 5 days of 15% polyethylene glycol (PEG)-stimulated drought stress, as demonstrated by increased shoot lengths and shoot and root dry weights, while showing decreased content of hydrogen peroxide (H2O2) and malondialdehyde (MDA). Under drought stress conditions, ABA markedly increased content of GSH and ASA in both leaves and roots of ABA-treated plants. Temporal and spatial expression patterns of eight genes encoding ASA and GSH synthesis-related enzymes were measured using quantitative real-time reverse transcription polymerase chain reaction (qPCR). The results showed that ABA temporally regulated the transcript levels of genes encoding ASA-GSH cycle enzymes. Moreover, these genes exhibited differential expression patterns between the root and leaf organs of ABA-treated wheat seedlings during drought stress. These results implied that exogenous ABA increased the levels of GSH and ASA in drought-stressed wheat seedlings in time- and organ-specific manners. Moreover, the transcriptional profiles of ASA-GSH synthesis-related enzyme genes in the leaf tissue were compared between ABA- and salicylic acid (SA)-treated wheat seedlings under PEG-stimulated drought stress, suggesting that they increased the content of ASA and GSH by differentially regulating expression levels of ASA-GSH synthesis enzyme genes. Our results increase our understanding of the molecular mechanism of ABA-induced drought tolerance in higher plants.
Advanced Imaging (Positron Emission Tomography and Magnetic Resonance Imaging) and Image-Guided Biopsy in Initial Staging and Monitoring of Therapy of Lung Cancer

AbstractThe results of the National Lung Screening Trial strongly support early detection and definitive treatment to reduce lung cancer mortality. Once lung cancer is discovered, accurate staging at baseline is imperative to maximize patient benefit and cost-effective use of health care resources. Although computed tomography (CT) remains a powerful tool for staging of lung cancer, advances in other imaging modalities, specifically positron emission tomography/CT and magnetic resonance imaging, can improve baseline staging over CT alone and can allow a more rapid and accurate assessment of response to treatment. Although noninvasive imaging is extremely useful, tissue diagnosis remains the criterion standard for staging lung cancer and monitoring treatment response. Accordingly, tissue sampling using advanced bronchoscopic imaging guidance, such as ultrasound or electromagnetic navigation, allows precise tissue location and sampling of mediastinal nodes or lung nodules in the least invasive manner. In the future, bronchoscopy may allow real-time microscopic analysis.
Dairy Product Intake and Its Association with Body Weight and Cardiovascular Disease Risk Factors in a Population in Dietary Transition

Objective: Higher dairy product intake has shown beneficial effects on body weight, blood pressure, type 2 diabetes, and cardiovascular disease (CVD) risk factors in Caucasian populations. This study evaluated dairy product intake and its association with body weight and CVD risk profile among a population undergoing a dietary transition in Canada, the Nunavik Inuit. Methods: Data were collected from August 27 to October 1, 2004, in the 14 villages of Nunavik on a Canadian research icebreaker (Canadian Coast Guard ship Amundsen). Dairy product intake and calcium intake were evaluated in 543 Inuit using a food frequency questionnaire. Physiological (lipid profile, fasting glucose, and insulin) and anthropometrical measurements were also obtained. Results: The range of median dairy product intake extended from 120 g/d in the lowest tertile to 290 g/d in the highest tertile. The median of calcium intake was 524 mg/d. Participants in the highest tertile of dairy product consumption had higher body weight, fat-free mass, waist circumference, waist-to-hip ratio, and fasting glucose concentrations than participants in the lowest tertile (all p < 0.01). After adjustments for potential cofactors, no significant association was observed. A higher prevalence of Inuit participants with metabolic syndrome was observed in the higher tertile compared with the first tertile (10.3% vs 1.6%; p < 0.001). Conclusions: Higher dairy product intake in Nunavik Inuit is not related to protective effects on body weight and CVD. The consumption of dairy products in Nunavik Inuit is probably not sufficient to withdraw beneficial effects on body weight or CVD risk factors, as observed in North American populations.
Serous effusion cytology in gynecologic malignant mixed müllerian tumors

We reviewed 51 serous effusions (50 peritoneal/one pleural) from 38 patients with uterine (30 cases) and ovarian (eight cases) malignant mixed Müllerian tumors (MMMT). There were 16 patients (42%) with positive effusion cytology specimens; 13 cases (81%) were diagnosed as adenocarcinoma with three cases (19%) interpreted as having a sarcomatous component. Eight of 16 positive effusion specimens had cell block material available for immunoperoxidase (IP) study that included cytokeratin (AE1/3), vimentin, muscle specific actin (HHF) and S‐100 protein to determine if unsuspected mesenchymal components were present in the cases originally diagnosed as carcinoma (six cases), or sarcomas (two cases). in the six cases originally interpreted as carcinoma, three were diagnosed as adenocarcinoma and three as poorly differentiated carcinoma. All three of the cases considered adenocarcinoma and two of those diagnosed as poorly differentiated carcinoma reacted only with AE1/3 and vimentin. the remaining case, considered a poorly differentiated carcinoma, stained only with vimentin. in the two cases having cell blocks interpreted as having a sarcomatous component, only vimentin was positive in one while AE1/3, vimentin, HHF, and S‐100 were positive in the other. the case where all immunohistochemical stains were reactive contained both carcinomatous and sarcomatous components. in the three cases considered sarcomatous, the cytomorphologic features helpful in the recognition of a mesenchymal component included a dissociated smear pattern of pleomorphic round to oval cells and/or spindle cells. in retrospect, the IP stains did not alter any of the original diagnoses. From our series, we conclude that IP stains performed on serous effusions in cases of unsuspected MMMT are generally not helpful unless the cytomorphology is suspicious for a malignant mesenchymal component. to the best of our knowledge, we believe this to be the largest series reporting the effusion cytology findings in MMMT. © 1995 Wiley‐ Liss, Inc.
The contribution of Kv7 channels to pregnant mouse and human myometrial contractility

Premature birth accounts for approximately 75% of neonatal mortality and morbidity in the developed world. Despite this, methods for identifying and treating women at risk of preterm labour are limited and many women still present in preterm labour requiring tocolytic therapy to suppress uterine contractility. The aim of this study was to assess the utility of Kv7 channel activators as potential uterine smooth muscle (myometrium) relaxants in tissues from pregnant mice and women. Myometrium was obtained from early and late pregnant mice and from lipopolysaccharide (LPS)‐injected mice (day 15 of gestation; model of infection in pregnancy). Human myometrium was obtained at the time of Caesarean section from women at term (38–41 weeks). RT‐PCR/qRT‐PCR detected KCNQ and KCNE expression in mouse and human myometrium. In mice, there was a global suppression of all KCNQ isoforms, except KCNQ3, in early pregnancy (n= 6, P < 0.001 versus late pregnant); expression subsequently increased in late pregnancy (n= 6). KCNE isoforms were also gestationally regulated (P < 0.05). KCNQ and KCNE isoform expression was slightly down‐regulated in myometrium from LPS‐treated‐mice versus controls (P < 0.05, n= 3–4). XE991 (10 μM, Kv7 inhibitor) significantly increased spontaneous myometrial contractions in vitro in both human and mouse myometrial tissues (P < 0.05) and retigabine/flupirtine (20 μM, Kv7 channel activators) caused profound myometrial relaxation (P < 0.05). In summary, Kv7 activators suppressed myometrial contraction and KCNQ gene expression was sustained throughout gestation, particularly at term. Consequently, activation of the encoded channels represents a novel mechanism for treatment of preterm labour.