Miracle-dz/UniFAR-FTUs huggingface dataset:
An open virtual neighbourhood network to connect IoT infrastructures and smart objects — Vicinity: IoT enables interoperability as a service

The lack of interoperability is considered as the most important barrier to achieve the global integration of Internet-of-Things (IoT) ecosystems across borders of different disciplines, vendors and standards. Indeed, the current IoT landscape consists of a large set of isolated islands that do not constitute a real Internet, preventing the exploitation of the huge potential expected by Information and communications technology (ICT) visionaries and unfolding business opportunities facilitated by digitalization and automation. The VICINITY project will build and demonstrate a platform linking various ecosystems providing “interoperability as a service” for infrastructures in the IoT. The approach is bottom-up, decentralized, user-centric and standards-based without relying on a single standard.
THE CHEMICAL EVOLUTION OF THE DRACO DWARF SPHEROIDAL GALAXY

We present an abundance analysis based on high-resolution spectra of eight stars selected to span the full range in metallicity in the Draco dwarf spheroidal (dSph) galaxy. We find that [Fe/H] for the sample stars ranges from −1.5 to −3.0 dex. Combining our sample with previously published work for a total of 14 luminous Draco giants, we show that the abundance ratios [Na/Fe], [Mg/Fe], and [Si/Fe] for the Draco giants overlap those of Galactic halo giants at the lowest [Fe/H] probed, but are significantly lower for the higher Fe-metallicity Draco stars. For the explosive α-elements Ca and Ti, the abundance ratios for Draco giants with [Fe/H] > − 2.4 dex are approximately constant and slightly subsolar, well below values characteristic of Galactic halo stars. The s-process contribution to the production of heavy elements begins at significantly lower Fe metallicity than in the Galactic halo. Using a toy model we compare the behavior of the abundance ratios within the sample of Draco giants with those from the literature of Galactic globular clusters, and the Carina and Sgr dSph galaxies. The differences appear to be related to the timescale for buildup of the heavy elements, with Draco having the slowest rate. We note the presence of a Draco giant with [Fe/H] <−3.0 dex in our sample, and reaffirm that the inner Galactic halo could have been formed by early accretion of Galactic satellite galaxies and dissolution of young globular clusters, while the outer halo could have formed from those satellite galaxies accreted later.
Treg-Therapy Allows Mixed Chimerism and Transplantation Tolerance Without Cytoreductive Conditioning

Establishment of mixed chimerism through transplantation of allogeneic donor bone marrow (BM) into sufficiently conditioned recipients is an effective experimental approach for the induction of transplantation tolerance. Clinical translation, however, is impeded by the lack of feasible protocols devoid of cytoreductive conditioning (i.e. irradiation and cytotoxic drugs/mAbs). The therapeutic application of regulatory T cells (Tregs) prolongs allograft survival in experimental models, but appears insufficient to induce robust tolerance on its own. We thus investigated whether mixed chimerism and tolerance could be realized without the need for cytoreductive treatment by combining Treg therapy with BM transplantation (BMT). Polyclonal recipient Tregs were cotransplanted with a moderate dose of fully mismatched allogeneic donor BM into recipients conditioned solely with short‐course costimulation blockade and rapamycin. This combination treatment led to long‐term multilineage chimerism and donor‐specific skin graft tolerance. Chimeras also developed humoral and in vitro tolerance. Both deletional and nondeletional mechanisms contributed to maintenance of tolerance. All tested populations of polyclonal Tregs (FoxP3‐transduced Tregs, natural Tregs and TGF‐β induced Tregs) were effective in this setting. Thus, Treg therapy achieves mixed chimerism and tolerance without cytoreductive recipient treatment, thereby eliminating a major toxic element impeding clinical translation of this approach.
The Influence of Declining Air Lead Levels on Blood Lead–Air Lead Slope Factors in Children

Background: It is difficult to discern the proportion of blood lead (PbB) attributable to ambient air lead (PbA), given the multitude of lead (Pb) sources and pathways of exposure. The PbB–PbA relationship has previously been evaluated across populations. This relationship was a central consideration in the 2008 review of the Pb national ambient air quality standards. Objectives: The objectives of this study were to evaluate the relationship between PbB and PbA concentrations among children nationwide for recent years and to compare the relationship with those obtained from other studies in the literature. Methods: We merged participant-level data for PbB from the National Health and Nutrition Examination Survey (NHANES) III (1988–1994) and NHANES 9908 (1999–2008) with PbA data from the U.S. Environmental Protection Agency. We applied mixed-effects models, and we computed slope factor, d[PbB]/d[PbA] or the change in PbB per unit change in PbA, from the model results to assess the relationship between PbB and PbA. Results: Comparing the NHANES regression results with those from the literature shows that slope factor increased with decreasing PbA among children 0–11 years of age. Conclusion: These findings suggest that a larger relative public health benefit may be derived among children from decreases in PbA at low PbA exposures. Simultaneous declines in Pb from other sources, changes in PbA sampling uncertainties over time largely related to changes in the size distribution of Pb-bearing particulate matter, and limitations regarding sampling size and exposure error may contribute to the variability in slope factor observed across peer-reviewed studies. Citation: Richmond-Bryant J, Meng Q, Davis A, Cohen J, Lu SE, Svendsgaard D, Brown JS, Tuttle L, Hubbard H, Rice J, Kirrane E, Vinikoor-Imler LC, Kotchmar D, Hines EP, Ross M. 2014. The Influence of declining air lead levels on blood lead–air lead slope factors in children. Environ Health Perspect 122:754–760; http://dx.doi. org/10.1289/ehp.1307072
Fiches techniques des arbres utiles aux paysans du Nord Cameroun. Caractéristiques de l'arbre, ce qu'en font les paysans et ce qu'ils pourraient en faire

This booklet on trees that are useful for North Cameroonian farmers has been designed as a resource for development practicioners. It is gathering on data sheets species that are the most used by farmers, based on field studies and our field knowledge, free of consideration on what is good or not for farmers or what he/she can handle or not. The spirit is firsly to build up a range of possibilities of development agents could propose to farmers. These data sheets on useful fruits aim to help farmers, nurserymen and agroforestry agents to discuss the best trees to be promoted on the different areas of the terroir, and the best management to apply.
Activation of p53 tumor suppressor by hepatitis C virus core protein.

In addition to being a structural protein that packages the viral genomic RNA, hepatitis C virus (HCV) core protein possesses regulatory functions. In this report, we demonstrate that the HCV core protein could enhance the gene transactivation activity of the tumor suppressor p53, regardless of whether p53 was derived from an exogenous or an endogenous gene. The activation of p53 by the HCV core protein was supported by the observation that the HCV core protein could enhance the expression of p21(waf1/Cip1), a downstream effector gene of p53, in a p53-dependent manner. Further studies indicated that the HCV core protein could also suppress hepatocellular growth via p53. The HCV core protein and p53 could bind to each other in vitro, which was evidenced by the coimmunoprecipitation, the GST pull-down, and the Far-Western blot assays. The deletion-mapping analysis indicated that the carboxy-terminal sequence of p53 located between amino acids 366 and 380 was required for the core protein binding. These results raised the possibility that the HCV core protein might activate p53 through direct physical interaction. The persistent perturbation of p53 activity by the HCV core protein during chronic infection may have important consequences in HCV pathogenesis.
Kinetics and expression patterns of chemokine receptors in human CD4+ T lymphocytes primed by myeloid or plasmacytoid dendritic cells

We investigated the kinetics of expression of 12 chemoattractant receptors as a function of cell division following priming of human naive CD4+ T cells by different populations of dendritic cells (DC) and under conditions favoring Th1 or Th2 differentiation. Two chemokine receptors, CXCR3 and CXCR5, were rapidly up‐regulated following T cell activation by either monocyte‐derivedDC, myeloid DC (mDC) or plasmacytoid DC (pDC). While CXCR5 expression was transient, expression of CXCR3 at advanced cell divisions was dependent on differentiation, being expressed at high levels on Th1 cells. Several other receptors (CCR2, CCR3, CCR4, CCR5, CXCR6 and CRTh2) were acquired progressively as a function of cell division and in a fashion that was influenced by polarizing cytokines. The Th2‐associated chemoattractant receptors CRTh2 and CCR3 were up‐regulated with slower kinetics compared to the Th1‐associated receptors CXCR3 and CXCR6, consistent with a different kinetics and efficiency of polarization. Moreover, CCR4 and CXCR6 were preferentially induced in T cells activated by mDC and pDC, respectively. Finally, CXCR5 and CCR7 were also rapidly and transiently up‐regulated in memory T cells following TCR stimulation. These results indicate a complex chemokine receptor regulation dependent on both T cell activation and differentiation state. In addition, they reveal the existence of DC‐specific cues for the regulation of T cell migratory capacity.
Identifying Failure-Inducing Combinations Using Tuple Relationship

Combinatorial testing (CT) aims at detecting interaction failures between parameters in a system. Identifying the failure-inducing combinations of a failing test configuration can help developers find the cause of this failure. However, most studies in CT focus on detecting the failures rather than identifying failure-inducing combinations. In this paper, we propose the notion of a tuple relationship tree (TRT) to describe the relationships among all the candidate parameter interactions. TRT reduces additional test configurations that need to be generated in the fault localization process, and it also provides a clear view of all possible candidate interactions. As a result, our approach will not omit any possible interaction that could be the cause of a failure. In particular, we can identify multiple failure-inducing combinations that overlap with each other. Moreover, we extend our approach to handle the case where additional failure-inducing combinations may be introduced by newly generated test configurations.
Effect of cimetidine on hepatotoxicity induced by isoniazid-rifampicin combination in rabbits.

OBJECTIVE To evaluate the hepatoprotective potential of cimetidine in hepatotoxicity induced by isoniazid-rifampicin combination in albino rabbits. METHODS Six groups of six rabbits each were studied. Three groups received saline (control), isoniazid (50 mg/Kg/d) alone or isoniazid with rifampicin (100 mg/Kg/d) daily orally for 7 days. Other groups received intraperitoneal cimetidine (50 mg/Kg/d) alone or cimetidine (50 or 120 mg/Kg/d) along with isoniazid-rifampicin combination. Serum levels of liver enzymes were measured at baseline and on day 8 and liver histology was studied on day 8. RESULTS Rabbits receiving isoniazid alone for 7 days showed no increase in serum ALT and AST levels, whereas those receiving isoniazid-rifampicin combination had a 3-4-fold increase in these levels (p=0.02). Animals receiving cimetidine pre-treatment did not show a significant increase in ALT and AST levels. Histological changes in the liver were more common with isoniazid-rifampicin combination than with isoniazid only. These changes were reduced in animals receiving low-dose cimetidine and prevented in those receiving high-dose cimetidine. CONCLUSION Cimetidine in high dose can prevent hepatotoxicity induced by isoniazid-rifampicin combination.
Sedimentological and petrographic analysis of drill core FC77‐1 from the flank of the central uplift, Flynn Creek impact structure, Tennessee

Drill core FC77‐1 on the flank of the central uplift, Flynn Creek impact structure, Tennessee, contains 175 m of impact breccia lying upon uplifted Lower Paleozoic carbonate target stratigraphy. Sedimentological analysis of this 175‐m interval carbonate breccia shows that there are three distinct sedimentological units. In stratigraphic order, unit 1 (175–109 m) is an overall coarsening‐upward section, whereas the overlying unit 2 (109–32 m) is overall fining‐upward. Unit 3 (32–0 m) is a coarsening‐upward sequence that is truncated at the top by postimpact erosion. Units 1 and 3 are interpreted as debris or rock avalanches into finer sedimentary deposits within intracrater marine waters, thus producing progressively coarser, coarsening‐upward sequences. Unit 2 is interpreted to have formed by debris or rock avalanches into standing marine waters, thus forming sequential fining‐upward deposits. Line‐logging of clasts ranging from 5 mm to 1.6 m, and thin‐section analysis of selected drill core samples (including clasts < 5 mm), both show that the Flynn Creek impact breccia consists almost entirely of dolostone clasts (90%), with minor components of cryptocrystalline melt clasts, chert and shale fragments, and clastic grains. Cryptocrystalline melt clasts, which appear isotropic in thin section, are in fact made of exceedingly fine quartz crystals that exhibit micro‐Fourier transform infrared (FTIR) and micro‐Raman spectra consistent with crystalline quartz. These cryptocrystalline melt clasts are the first melt clasts of any kind to be reported from Flynn Creek impact structure.
Effects of Long-Term Oral Administration of Arachidonic Acid and Docosahexaenoic Acid on the Immune Functions of Young Rats

Natural killer (NK) cells have many functional activities, including cytotoxicity and the capacity to produce cytokines and chemokines. NK cell activity is regulated partly by eicosanoids, which are produced from arachidonic acid (ARA) and eicosapentaenoic (EPA) acid. In this study, we investigated the effects of long-term therapy with ARA or docosahexaenoic acid (DHA) on the cytotoxic effects of the NK cells of young rats, which were fed on a nonfish oil diet for two generations. Control oil, ARA (240 mg/kg BW/day) or DHA (240 mg/kg BW/day) were orally administrated to the rats for 13 weeks before determining the cytotoxic activity of NK cells from the spleen against YAC-1 mouse lymphoma cell line, as well as the plasma levels of docosanoids or eicosanoids and inflammatory cytokines. Long-term ARA administration significantly suppressed the cytotoxic activity of NK cells. Moreover, ARA administration significantly increased the plasma levels of ARA, prostaglandin (PG) E2, and PGD2. However, DHA administration did not produce any different effects compared with those in the control rats. Furthermore, the inflammatory cytokine levels were not affected by the administration of ARA or DHA. These results suggest that long-term ARA administration has an inhibitory effect on the tumor cytotoxicity of NK cells in rat spleen lymphocytes owing to the enhanced synthesis of PGE2 and PGD2 from ARA because of the elevated plasma ARA levels in young rats.
MOPSI location-based search engine: concept, architecture and prototype

Traditional location-based services use databases where all entries have been explicitly georeferenced beforehand. We propose an alternative approach based on web search and using ad-hoc georeferencing of web-pages. We denote it as location-based search engine and emphasize its seemingly small but significant distinction from traditional location-based services. We outline how to construct such search engine and prove its effectiveness using a prototype called MOPSI search.
High-throughput gene targeting and phenotyping in zebrafish using CRISPR/Cas9

The use of CRISPR/Cas9 as a genome-editing tool in various model organisms has radically changed targeted mutagenesis. Here, we present a high-throughput targeted mutagenesis pipeline using CRISPR/Cas9 technology in zebrafish that will make possible both saturation mutagenesis of the genome and large-scale phenotyping efforts. We describe a cloning-free single-guide RNA (sgRNA) synthesis, coupled with streamlined mutant identification methods utilizing fluorescent PCR and multiplexed, high-throughput sequencing. We report germline transmission data from 162 loci targeting 83 genes in the zebrafish genome, in which we obtained a 99% success rate for generating mutations and an average germline transmission rate of 28%. We verified 678 unique alleles from 58 genes by high-throughput sequencing. We demonstrate that our method can be used for efficient multiplexed gene targeting. We also demonstrate that phenotyping can be done in the F1 generation by inbreeding two injected founder fish, significantly reducing animal husbandry and time. This study compares germline transmission data from CRISPR/Cas9 with those of TALENs and ZFNs and shows that efficiency of CRISPR/Cas9 is sixfold more efficient than other techniques. We show that the majority of published “rules” for efficient sgRNA design do not effectively predict germline transmission rates in zebrafish, with the exception of a GG or GA dinucleotide genomic match at the 5′ end of the sgRNA. Finally, we show that predicted off-target mutagenesis is of low concern for in vivo genetic studies.
Health-related quality of life in primary Sjögren's syndrome, rheumatoid arthritis and fibromyalgia compared to normal population data using SF-36

Objective: To investigate the health-related quality of life in women with primary Sjögren's syndrome (prim SS) and compare with normative data and the healthrelated quality of life in women with rheumatoid arthritis (RA) and women with fibromyalgia. Methods: A questionnaire including the MOS Short-Form 36 (SF-36) was completed by 42 prim SS women, 59 RA women, and 44 women with fibromyalgia.Results
Secular Trends in Energy Intake and Diet Quality in a Mediterranean Population

Background/Aims: Assessing secular trends of diet quality at the population scale is an important tool for health policymakers. The aim of this study was to describe secular trends in energy intake and diet quality in a representative Mediterranean population, accounting for energy underreporting. Methods: We analyzed the dietary data from 4,061 men and 4,409 women who were included in 2 population-based cross-sectional studies conducted in northeast Spain in 2000 and 2005. The surveys included randomly selected free-living men and women between 35 to 74 years of age. Results: No significant differences in reported energy intake between 2000 and 2005 were observed. Protein (p = 0.014) and carbohydrate (p = 0.02) consumption (expressed as percent of total energy intake) decreased in men and women, respectively. Energy density and intake of total, saturated and monounsaturated fat were significantly higher (p < 0.001) in 2005 than in 2000 in both genders. In contrast, lower consumption of fibre, fruit and meat (p < 0.001) was observed for both genders in 2005 compared to 2000. A significantly lower proportion of men and women met the recommended intake for carbohydrates, total fat, saturated fat, cholesterol and fruits in 2005 when compared to 2000. When energy underreporters were excluded from the analysis, a decline in energy intake (p < 0.001) and an increase in fish consumption (p < 0.001) between 2000 and 2005 was observed in men; no other significant differences were found in diet quality and food consumption trends among non-underreporters. Conclusions: Whereas energy intake remained stable from 2000 to 2005, overall diet quality showed an unfavourable trend during this timeframe. Secular dietary trends did not change their magnitude or direction, with the exception of energy and fish consumption in men, after excluding energy underreporters from the analysis.
An Analysis of Pharmaceutical Experience with Decades of Rat Carcinogenicity Testing

Data collected from 182 marketed and nonmarketed pharmaceuticals demonstrate that there is little value gained in conducting a rat two-year carcinogenicity study for compounds that lack: (1) histopathologic risk factors for rat neoplasia in chronic toxicology studies, (2) evidence of hormonal perturbation, and (3) positive genetic toxicology results. Using a single positive result among these three criteria as a test for outcome in the two-year study, fifty-two of sixty-six rat tumorigens were correctly identified, yielding 79% test sensitivity. When all three criteria were negative, sixty-two of seventy-six pharmaceuticals (82%) were correctly predicted to be rat noncarcinogens. The fourteen rat false negatives had two-year study findings of questionable human relevance. Applying these criteria to eighty-six additional chemicals identified by the International Agency for Research on Cancer as likely human carcinogens and to drugs withdrawn from the market for carcinogenicity concerns confirmed their sensitivity for predicting rat carcinogenicity outcome. These analyses support a proposal to refine regulatory criteria for conducting a two-year rat study to be based on assessment of histopathologic findings from a rat six-month study, evidence of hormonal perturbation, genetic toxicology results, and the findings of a six-month transgenic mouse carcinogenicity study. This proposed decision paradigm has the potential to eliminate over 40% of rat two-year testing on new pharmaceuticals without compromise to patient safety.
A multinational comparison of subarachnoid hemorrhage epidemiology in the WHO MONICA stroke study.

BACKGROUND AND PURPOSE By official, mostly unvalidated statistics, mortality from subarachnoid hemorrhage (SAH) show large variations between countries. Using uniform criteria for case ascertainment and diagnosis, a multinational comparison of attack rates and case fatality rates of SAH has been performed within the framework of the WHO MONICA Project. METHODS In 25- to 64-year-old men and women, a total of 3368 SAH events were recorded during 35.9 million person-years of observation in 11 populations in Europe and China. Strict MONICA criteria were used for case ascertainment and diagnosis of stroke subtype. Case fatality was based on follow-up at 28 days after onset. RESULTS Age-adjusted average annual SAH attack rates varied 10-fold among the 11 populations studied, from 2.0 (95% CI 1.6 to 2.4) per 100 000 population per year in China-Beijing to 22.5 (95% CI 20.9 to 24.1) per 100 000 population per year in Finland. No consistent pattern was observed in the sex ratio of attack rates in the different populations. The overall 28-day case fatality rate was 42%, with 2-fold differences in age-adjusted rates between populations but little difference between men and women. Case fatality rates were consistently higher in Eastern than in Western Europe. CONCLUSIONS Using a uniform methodology, the WHO MONICA Project has shown very large variations in attack rates of SAH across 11 populations in Europe and China. The generally accepted view that women have a higher risk of SAH than men does not apply to all populations. Marked differences in outcome of SAH add to the wide gap in the burden of stroke between East and West Europe.