Miracle-dz/UniFAR-FTUs huggingface dataset:
A comparison of temporal variability of observed and model‐based pan evaporation over Uruguay (1973–2014)

This study analyses variability and trends of atmospheric evaporative demand (AED) across Uruguay in the past four decades. Changes were assessed using pan evaporation measurements from 10 meteorological stations and compared to PenPan model calculations, which is a physically based model that employs meteorological data as input. Results demonstrate a high agreement between the observed AED and those estimated from the PenPan model. Both observations and model estimations agree on a high interannual variability in AED, though being statistically insignificant (p > 0.05) at seasonal and annual scales. Given that AED shows high sensitivity to changes in relative humidity and sunshine duration, as a surrogate of solar radiation, the lack of significant trends in the AED observations and estimations over Uruguay can be linked to the insignificant trend found for these climate variables for the period from 1973 to 2014. This is the first study that reports Pan evaporation trends for this part of the world, helping to infill gaps for mid‐latitude Southern Hemisphere areas, which are poorly represented in Pan evaporation trends.
Task 1: ShARe/CLEF eHealth Evaluation Lab 2013

This report outlines the Task 1 of the ShARe/CLEF eHealth evaluation lab pilot. This task focused on identification (1a) and normalization (1b) of diseases and disorders in clinical reports. It used annotations from the ShARe corpus. A total of 22 teams competed in Task 1a and 17 of them also participated Task 1b. The best systems had an F1 score of 0.75 (0.80 Precision, 0.71 Recall) in Task 1a and an accuracy of 0.59 in Task 1b. The organizers have made the text corpora, annotations, and evaluation tools available for future research and development.
The nondeclaration of nonmotor symptoms of Parkinson's disease to health care professionals: An international study using the nonmotor symptoms questionnaire

The nonmotor symptoms (NMS) of Parkinson's disease (PD) are less well recognised and can be more troublesome to patients and carers than classical motor features. NMS are frequently missed during routine consultations and such under‐recognition may have implications on quality of care given that many NMS are treatable. To determine the proportion of patients not declaring NMS to healthcare professional (HCP) as assessed by self completion of the NMS questionnaire (NMSQuest), a validated, self‐completing questionnaire with 30 items. Multicentre international study. The data was collected from PD patients across all age groups and stages attending outpatient clinics in specialist and care of the elderly settings. 242 patients recruited and undeclared NMS ranged from 31.8% (diplopia) to 65.2% (delusions). The most frequently nondeclared symptoms were delusions, daytime sleepiness, intense and vivid dreams, and dizziness. In many, appropriate treatments for undeclared NMS were started only after these were recognised following completion of NMSQuest. NMS of PD are frequently undeclared at routine hospital consultation and may be related to the fact that patients often do not link these symptoms with PD or may be too embarrassed to discuss these. Use of NMSQuest allows patients to flag symptoms which may be otherwise undeclared and remain untreated when potential treatments exist. © 2010 Movement Disorder Society
Tactile mesh saliency

While the concept of visual saliency has been previously explored in the areas of mesh and image processing, saliency detection also applies to other sensory stimuli. In this paper, we explore the problem of tactile mesh saliency, where we define salient points on a virtual mesh as those that a human is more likely to grasp, press, or touch if the mesh were a real-world object. We solve the problem of taking as input a 3D mesh and computing the relative tactile saliency of every mesh vertex. Since it is difficult to manually define a tactile saliency measure, we introduce a crowdsourcing and learning framework. It is typically easy for humans to provide relative rankings of saliency between vertices rather than absolute values. We thereby collect crowdsourced data of such relative rankings and take a learning-to-rank approach. We develop a new formulation to combine deep learning and learning-to-rank methods to compute a tactile saliency measure. We demonstrate our framework with a variety of 3D meshes and various applications including material suggestion for rendering and fabrication.
Anti-streptokinase antibodies and streptokinase resistance in an Aboriginal population in northern Australia.

BACKGROUND Thrombolytic treatment with streptokinase in acute myocardial infarction has proven to be safe and effective in Caucasian populations with relatively low levels of anti-streptokinase IgG and streptokinase resistance. Higher levels of antibodies, as seen in previous recipients of streptokinase therapy, cause more adverse reactions and may result in lower efficacy. AIMS To examine the levels of anti-streptokinase IgG and streptokinase resistance in a population subjected to endemic streptococcal infections. METHODS AND RESULTS Thirty Aboriginal adults from a remote community in Northern Australia with endemic streptococcal infections and 15 non-Aboriginal adults from an urban community without endemic infections participated in this study. Aboriginal adults exhibited levels of anti-streptokinase IgG and streptokinase resistance that, respectively, were almost 20 and 15 times greater than the values of non-Aboriginal adults. At least 23% of Aboriginal adults had sufficiently high levels of streptokinase resistance to neutralise a standard 1.5 million unit dose of streptokinase. CONCLUSIONS Aboriginal adults from a remote community had dramatically elevated levels of anti-streptokinase IgG and in vitro streptokinase resistance. Prospective studies are needed to assess the clinical relevance of streptokinase resistance in populations from areas with endemic streptococcal infection.
Multiple Mechanisms Contribute to Schizosaccharomyces pombe Origin Recognition Complex-DNA Interactions*

Eukaryotic DNA replication requires the assembly of multiprotein pre-replication complexes (pre-RCs) at chromosomal origins of DNA replication. Here we describe the interactions of highly purified Schizosaccharomyces pombe pre-RC components, SpORC, SpCdc18, and SpCdt1, with each other and with ars1 origin DNA. We show that SpORC binds DNA in at least two steps. The first step likely involves electrostatic interactions between the AT-hook motifs of SpOrc4 and AT tracts in ars1 DNA and results in the formation of a salt-sensitive complex. In the second step, the salt-sensitive complex is slowly converted to a salt-stable complex that involves additional interactions between SpORC and DNA. Binding of SpORC to ars1 DNA is facilitated by negative supercoiling and is accompanied by changes in DNA topology, suggesting that SpORC-DNA complexes contain underwound or negatively writhed DNA. Purified human origin recognition complex (ORC) induces similar topological changes in origin DNA, indicating that this property of ORC is conserved in eukaryotic evolution and plays an important role in ORC function. We also show that SpCdc18 and SpCdt1 form a binary complex that has greater affinity for DNA than either protein alone. In addition, both proteins contribute significantly to the stability of the initial SpORC-DNA complex and enhance the SpORC-dependent topology changes in origin DNA. Thus, the formation of stable protein-DNA complexes at S. pombe origins of replication involves binary interactions among all three proteins, as well as interactions of both SpORC and SpCdt1-SpCdc18 with origin DNA. These findings demonstrate that SpORC is not the sole determinant of origin recognition.
Depression following traumatic brain injury: Impact on post-hospital residential rehabilitation outcomes.

BACKGROUND A need exists to better understand the impact of depression on functional outcomes following TBI. OBJECTIVES To evaluate the prevalence and severity of depression among a large group of chronic TBI adults; to determine the impact of depression on outcomes of post-hospital residential rehabilitation programs; and to assess effectiveness of post-hospital residential rehabilitation programs in treating depression. METHODS 820 adults with moderate to severe traumatic brain injury (TBI) were assigned to one of four groups based on MPAI- 4 depression ratings: (1) Not Depressed, (2) Mildly Depressed, (3) Moderately Depressed, and (4) Severely Depressed. Functional status was assessed at admission and discharge with the MPAI-4 Participation Index. Differences among groups were evaluated using conventional parametric tests. Rasch analysis established reliability and validity of MPAI-4 data. RESULTS Rasch analysis demonstrated satisfactory construct validity and internal consistency (Person reliability = 0.89-0.92, Item reliability = 0.99). Of the 820 subjects, 39% presented with moderate to severe depressive symptoms at admission, These subjects demonstrated significantly higher MPAI-4 Participation scores than the mild and not depressed groups. Depressed groups realized significant improvement in symptoms, but, those remaining depressed at discharge had significantly greater disability than those who improved. CONCLUSIONS Depressive symptoms had a deleterious impact on outcome. Remediation of symptoms during rehabilitation significantly improved outcomes.
Production System Design and Evaluation for Increased System Robustness

Effective and robust production systems are required in the competitive environment of today’s manufacturing companies. Creating system robustness should be made during the design phase and not during operation when most system parameters already are set. Each production system is the result of a unique and context dependent development process, and its comprising design and evaluation activities are most vital for system performance. The full-text paper is based upon results from more than ten years of theoretical and empirical research studies in the field of production system design and evaluation and lately also in the 1 Monica Bellgran's main research area concerns production system design. 2 Kristina Safsten’s main research area concerns production system evaluation. field of robust production systems concerning e.g. manufacturing efficiency and disturbance handling. Industrial examples of how production systems are designed and evaluated will be shown, and its consequences discussed in terms of system robustness and performance in a life-cycle perspective. Issues of importance are e.g. the use of systematic procedures and methods and decisions concerning personal competence and learning strategies.
Quantifying the Response Time of a Lake–Groundwater Interacting System to Climatic Perturbation

Response time, describing how quickly a disturbed system would reach a new equilibrium, has been helpful to hydrogeologists in characterizing and understanding the hydrogeological systems. This study examined the complex response times associated with lake–groundwater perturbed by climate. Simulated hydraulic heads and lake stage values derived from a 3-D, MODFLOW-based model were used to calculate the response times for a closed, groundwater-fed lake system. Although obviously coupled, the response times of the lake and groundwater systems were different from one another. Typically, the adjustments in hydraulic heads occurred more rapidly than lake stage. Response times for groundwaters close to the lake were controlled by the lake because of the slow transient response in stage. However, the influence of the lake declined toward the basin boundaries. This behavior occurred because critical parameters controlling the response-time behavior of the groundwater system (e.g., recharge rate) differed from those controlling the response-time behavior of the lake (e.g., bed leakance). An improved understanding of lake–groundwater behaviors have the potential to evaluate how lakes function as systems for recording paleoclimates.
DEUCON: Decentralized End-to-End Utilization Control for Distributed Real-Time Systems

Many real-time systems must control their CPU utilizations in order to meet end-to-end deadlines and prevent overload. Utilization control is particularly challenging in distributed real-time systems with highly unpredictable workloads and a large number of end-to-end tasks and processors. This paper presents the decentralized end-to-end utilization control (DEUCON) algorithm, which can dynamically enforce the desired utilizations on multiple processors in such systems. In contrast to centralized control schemes adopted in earlier works, DEUCON features a novel decentralized control structure that requires only localized coordination among neighbor processors. DEUCON is systematically designed based on advances in distributed model predictive control theory. Both control-theoretic analysis and simulations show that DEUCON can provide robust utilization guarantees and maintain global system stability despite severe variations in task execution times. Furthermore, DEUCON can effectively distribute the computation and communication cost to different processors and tolerate considerable communication delay between local controllers. Our results indicate that DEUCON can provide a scalable and robust utilization control for large-scale distributed real-time systems executing in unpredictable environments.
Early and long-term outcomes of endoscopic submucosal dissection for early gastric cancer in a large patient series

Endoscopic submucosal dissection (ESD) enables the curative resection of early gastric cancer (EGC); however, little information is available on the long-term outcomes of ESD. This study was conducted to clarify the clinical outcomes of a large number of patients with EGC who underwent ESD. The early outcomes were assessed in 1,209 patients and the long-term outcomes were assessed in 300 patients at a follow-up >5 years after the ESD procedure. The overall survival rates were compared between indication and expanded-indication groups, and between the patients who did or did not undergo additional surgery in an out-of-indication group. Overall survival rates were also compared among different age groups. In total, 617 lesions were classed as the indication group, 507 as the expanded-indication group and 208 as the out-of-indication group. Curative resection rates were 96.6% and 91.5% in the indication and expanded-indication groups, respectively. In terms of the long-term outcomes, 20 of the 146 patients in the indication group, 15 of the 105 patients in the expanded-indication group and one of the 23 patients who underwent additional surgery in the out-of-indication group succumbed due to causes other than gastric cancer. Among the 26 patients who did not undergo additional surgery in the out-of-indication group, 10 mortalities occurred, including one due to gastric cancer. The five-year survival rates were not significantly different between the indication and expanded-indication groups. In the out-of-indication group, the five-year survival rate for the patients who did not undergo additional surgery (65.0%) was significantly lower than that for those who did undergo additional surgery (100%) (P<0.01). The five-year survival rate of patients aged >80 years (67.1%) was significantly lower than that of the younger patients (<60 years, 91.6%; sixties, 93.0%; seventies, 84.5%) (P<0.0001). In conclusion, although expanded-indication of ESD for EGC is appropriate, comorbidities require consideration in elderly patients.
Mechanisms of differential toxicity between honey bee ( Apis mellifera L.) castes with an emphasis on coumaphos

Acaricides are used to treat honey bee (Apis mellifera L.) colonies to control the varroa mite (Varroa destructor Anderson & Trueman), a worldwide threat to honey bee health. Although acaricides control a serious honey bee parasite and mitigate bee loss, they may cause harm to bees as well. We topically applied five acaricides, each with a different mode of action, to young adult queen and worker bees to generate dose-response curves and LD50. Twenty-four hours after treatment, queens were found to be three-times more tolerant of tau-fluvalinate and six-times more tolerant of thymol than workers when adjusted for body weight differences between workers (108 mg) and queens (180 mg). Queens survived the highest administered doses of fenpyroximate (1620 μg/g) and coumaphos (2700 μg/g) indicating that queens are at least 11-fold more tolerant of coumaphos and at least 54-fold more tolerant of fenpyroximate than workers. However, queens treated with as little as 54 μg/g of fenpyroximate exhibited reduced survival over 6 wk after treatment. Amitraz was the only acaricide tested for which queens were not more tolerant than workers. The striking difference in acaricide tolerance of queen and worker honey bees suggests physiological differences in how the two castes are affected by xenobiotics.
Human Articular Cartilage Progenitor Cells Are Responsive to Mechanical Stimulation and Adenoviral-Mediated Overexpression of Bone-Morphogenetic Protein 2

Articular cartilage progenitor cells (ACPCs) represent a new and potentially powerful alternative cell source to commonly used cell sources for cartilage repair, such as chondrocytes and bone-marrow derived mesenchymal stem cells (MSCs). This is particularly due to the apparent resistance of ACPCs to hypertrophy. The current study opted to investigate whether human ACPCs (hACPCs) are responsive towards mechanical stimulation and/or adenoviral-mediated overexpression of bone morphogenetic protein 2 (BMP-2). hACPCs were cultured in fibrin-polyurethane composite scaffolds. Cells were cultured in a defined chondro-permissive medium, lacking exogenous growth factors. Constructs were cultured, for 7 or 28 days, under free-swelling conditions or with the application of complex mechanical stimulation, using a custom built bioreactor that is able to generate joint-like movements. Outcome parameters were quantification of BMP-2 and transforming growth factor beta 1 (TGF-β1) concentration within the cell culture medium, biochemical and gene expression analyses, histology and immunohistochemistry. The application of mechanical stimulation alone resulted in the initiation of chondrogenesis, demonstrating the cells are mechanoresponsive. This was evidenced by increased GAG production, lack of expression of hypertrophic markers and a promising gene expression profile (significant up-regulation of cartilaginous marker genes, specifically collagen type II, accompanied by no increase in the hypertrophic marker collagen type X or the osteogenic marker alkaline phosphatase). To further investigate the resistance of ACPCs to hypertrophy, overexpression of a factor associated with hypertrophic differentiation, BMP-2, was investigated. A novel, three-dimensional, transduction protocol was used to transduce cells with an adenovirus coding for BMP-2. Over-expression of BMP-2, independent of load, led to an increase in markers associated with hypertropy. Taken together ACPCs represent a potential alterative cell source for cartilage tissue engineering applications.
A Temporal Reference Framework for Multimedia Synchronization

The synchronization problem for audio/visual reproduction has consumed engineers time since the advent of recorded audio and images and the first multimedia productions. As computers have evolved to support programmed reproduction of multimedia information, the complexity but not the character or interest have changed. In the digital domain, synchronization problems exist due to data distribution and communications, random events caused by human-computer interaction, and general computer and communications performance limitations. This rich research domain has led to numerous approaches to the modeling and execution of multimedia synchronization scenarios. Unfortunately, these approaches are difficult to compare and evaluate due to their varied theoretical bases and modeling techniques. We develop a uniform, theoretical foundation for discussing multimedia synchronization and temporal specification. We propose a temporal reference framework and use it to compare existing temporal specification schemes and their relationships to multimedia synchronization. The ensuing comparison of existing specification and synchronization techniques demonstrates the utility of the framework.
Fornix Lesions Can Facilitate Acquisition of the Transverse Patterning Task: A Challenge for “Configural” Theories of Hippocampal Function

Configural theories of hippocampal function predict that hippocampal dysfunction should impair acquisition of the transverse patterning task, which involves the concurrent solution of three discrimination problems: A+ versus B−; B+ versus C−; and C+ versus A−. The present study tested this prediction in rats using computer-graphic stimuli presented on a touchscreen. Experiment 1 assessed the effects of fornix lesions when the three problems were introduced sequentially (phase 1: A+ vs B−; phase 2: A+ vs B−, B+ vs C−; phase 3: A+ vs B−, B+ vs C−, C+ vs A−). Fornix lesions significantly facilitated acquisition of the complete transverse patterning task (phase 3) but had no effect on the number of sessions or errors required to attain criterion during phase 1 or phase 2. In experiment 2, in which all three problems were presented concurrently from the outset of training, fornix-lesioned animals outperformed control animals during the seventh block of acquisition trials and were not impaired during any stage of acquisition. Importantly, these same animals were significantly impaired on two allocentric spatial tasks: T-maze alternation (experiments 1 and 2) and the Morris Swim Task (experiment 1). These results contradict the predictions of configural theories of hippocampal function and cast doubt on the popular notion that spatial learning is a special case of configural learning.
Non-stationary future return levels for extreme rainfall over Extremadura (southwestern Iberian Peninsula)

ABSTRACT Based on a previous study for temperature, a new method for the calculation of non-stationary return levels for extreme rainfall is described and applied to Extremadura, a region of southwestern Spain, using the peaks-over-threshold approach. Both all-days and rainy-days-only datasets were considered and the 20-year return levels expected in 2020 were estimated taking different trends into account: first, for all days, considering a time-dependent threshold and the trend in the scale parameter of the generalized Pareto distribution; and second, for rainy days only, considering how the mean, variance, and number of rainy days evolve. Generally, the changes in mean, variance and number of rainy days can explain the observed trends in extremes, and their extrapolation gives more robust estimations. The results point to a decrease of future return levels in 2020 for spring and winter, but an increase for autumn.