Miracle-dz/UniFAR-FTUs huggingface dataset:
Associated systemic and ocular anomalies in patients with congenital anophthalmos or microphthalmos

Congenital anophthalmos and microphthalmos ere aree clinical conditions that results due to abnormalities in development of eye. These conditions may present unilaterally, bilaterally. A large number of these patients have associates systemic anomalies patients with unilateral anophthalmos and microphthalmos may present with congenital anomalies of the other eye. Objective: To document systemic and ocular anomalies in patients with congenital anophthalmos and micriopphthalmos. Materials and Methods: Retrospective study of documents of patients present tertiary care center in with congenital anophthalmos and microphthalmos from March 2014-2017. Associated ocular and systemic anomalies were assessed from their records. Results: Total 42 patients were present during study period. There were 10 (24%) patients with anophthalmos and 32 (76%) were having microphthalmos. 27 were unilateral and 15 bilateral involved. 24 male and 18 female. mean age of presentation was 9 months. Systemic anomalies was identified in 28% and 66% of unilateral and bilateral anophthalmos. While in microphthalmos systemic involvement was 10% and 30%. Ocular involvement was 40% and 33% in anophthalmos and microphthalmos respectively. Conclusion: Majority of patients with congenital anophthalmos and microipthamos have associated systemic and ocular anomalies. We suggest that all patients born with congenital anophthalmos and micropthlamos need complelte ophthlamic ans systemic examination. Keywords: Anophthaloms, Microphthalmos, Ocular anomalies, Systemic anomalies.
VEGF in hepatocellular carcinoma and surrounding cirrhotic liver tissues.

www.wjgnet. com Muriel Mathonnet, Service de Chirurgie Digestive, Endocrinienne et Générale, CHU Dupuytren, Limoges, France Bernard Descottes, Denis Valleix, Service de Chirurgie Viscérale et Transplantation, CHU Dupuytren, Limoges, France François Labrousse, Service d’Anatomo-Pathologie, CHU Dupuytren, Limoges, France Yves Denizot, UMR CNRS 6101, Faculté de Médecine, Limoges, France Correspondence to: Yves Denizot, UMR CNRS 6101, Faculté de Médecine, 2 rue Dr. Marcland, 87025 Limoges, France. yves.denizot@unilim.fr Telephone: +33-555-435896 Fax: +33-555-435897 Received: 2005-05-17 Accepted: 2005-08-25
On the resemblance and containment of documents

Given two documents A and B we define two mathematical notions: their resemblance r(A, B) and their containment c(A, B) that seem to capture well the informal notions of "roughly the same" and "roughly contained. " The basic idea is to reduce these issues to set intersection problems that can be easily evaluated by a process of random sampling that can be done independently for each document. Furthermore, the resemblance can be evaluated using a fixed size sample for each document. This paper discusses the mathematical properties of these measures and the efficient implementation of the sampling process using Rabin (1981) fingerprints.
The Role of egr1 in Early Zebrafish Retinogenesis

Proper retinal cell differentiation is essential for establishing a functional retina. The purpose of this study is to investigate the role of early growth response 1 (egr1), a transcription factor (TF) that has been reported to control eye development and function, on retinal differentiation in zebrafish. Specifically, cellular changes in the Egr1-knockdown retinas were characterized by immunohistochemistry at 72 and 120 hours post-fertilization (hpf). The results indicate that Egr1 knockdown specifically suppressed the differentiation of subtypes of amacrine cells (ACs) and horizontal cells (HCs), including Parvalbumin- and GABA-positive ACs as well as Islet1-positive HCs. In addition, the knockdown induced a general delay of development of the other retinal cell types. These differentiation problems, particularly the ones with the ACs and HCs, also compromised the integrity of the inner and outer plexiform layers. In the Egr1-knockdown retinas, the expression of ptf1a, a TF that controls the specification of ACs and HCs, was prolonged and found in ectopic locations in the retina up to 72 hpf. Then, it became restricted to the proliferative marginal zone as in the control retinas at 120 hpf. This abnormal and prolonged expression of ptf1a during retinogenesis might affect the differentiation of ACs and HCs in the Egr1-knockdown retinas.
Rutting and Fatigue Cracking Resistance of Waste Cooking Oil Modified Trinidad Asphaltic Materials

The influence of waste cooking oil (WCO) on the performance characteristics of asphaltic materials indigenous to Trinidad, namely, Trinidad Lake Asphalt (TLA), Trinidad Petroleum Bitumen (TPB), and TLA : TPB (50 : 50) blend, was investigated to deduce the applicability of the WCO as a performance enhancer for the base asphalt. The rheological properties of complex modulus (G ∗) and phase angle (δ) were measured for modified base asphalt blends containing up to 10% WCO. The results of rheology studies demonstrated that the incremental addition of WCO to the three parent binders resulted in incremental decreases in the rutting resistance (decrease in G ∗/sinδ values) and increases in the fatigue cracking resistance (decrease in G ∗sinδ value). The fatigue cracking resistance and rutting resistance for the TLA : TPB (50 : 50) blends were between those of the blends containing pure TLA and TPB. As operating temperature increased, an increase in the resistance to fatigue cracking and a decrease in the rutting resistance were observed for all of the WCO modified asphaltic blends. This study demonstrated the capability to create customized asphalt-WCO blends to suit special applications and highlights the potential for WCO to be used as an environmentally attractive option for improving the use of Trinidad asphaltic materials.
Chemistry and Immunomodulatory Activity of Frankincense Oil

The yield of steam distillation of frankincense essential oil (3%); and its physicochemical constants were determined. Capillary GC/MS technique was used for the analysis of the oil. Several oil components were identified based upon comparison of their mass spectral data with those of reference compounds published in literature or stored in a computer library. The oil was found to contain monoterpenes (13.1%), sesquiterpenes (1%), and diterpenes (42.5%). The major components of the oil were duva-3,9,13-trien-1,5α-diol-1-acetate (21.4%), octyl acetate (13.4%), o-methyl anisole (7.6%), naphthalene decahydro-1,1,4a-trimethyl- 6-methylene-5-(3-methyl-2-pentenyl) (5.7%), thunbergol (4.1%), phenanthrene-7- ethenyl-1,2,3,4,4a,5,6,7,8,9,10,10a-dodecahydro-1,1,4a,7-tetramethyl (4.1%), α-pinene (3.1%), sclarene (2.9%), 9-cis-retinal (2.8%), octyl formate (1.4%), verticiol (1.2%) decyl acetate (1.2%), n-octanol (1.1%). The chemical profile of the oil is considered as a chemotaxonomical marker that confirmed the botanical and geographical source of the resin. Biologically, the oil exhibited a strong immunostimulant activity (90% lymphocyte transformation) when assessed by a lymphocyte proliferation assay.
Apoplastic Synthesis of Nitric Oxide by Plant Tissues

Nitric oxide (NO) is an important signaling molecule in animals and plants. In mammals, NO is produced from Arg by the enzyme NO synthase. In plants, NO synthesis from Arg using an NO synthase–type enzyme and from nitrite using nitrate reductase has been demonstrated previously. The data presented in this report strongly support the hypothesis that plant tissues also synthesize NO via the nonenzymatic reduction of apoplastic nitrite. As measured by mass spectrometry or an NO-reactive fluorescent probe, Hordeum vulgare (barley) aleurone layers produce NO rapidly when nitrite is added to the medium in which they are incubated. NO production requires an acid apoplast and is accompanied by a loss of nitrite from the medium. Phenolic compounds in the medium can increase the rate of NO production. The possible significance of apoplastic NO production for germinating grain and for plant roots is discussed.
Attention Deficit Hyperactivity Disorder and Motor Impairment

Attention deficit hyperactivity disorder (ADHD) is the most common neurobehavioral disorder during childhood, affecting approximately 3–6% of school-aged children; its cardinal symptoms of high activity, impulsivity, and behavioral distractibility might be assumed to have close relationships to interferences with motor skills. A separate body of literature attests to ways that motor problems can severely impact children’s daily lives, as motor problems may occur in 30–50% of children with ADHD. This article critically reviews research on motor impairment in children with ADHD, notable differences in motor performance of individuals with ADHD compared with age-matched controls, and possible neural underpinnings of this impairment. We discuss the highly prevalent link between ADHD and developmental coordination disorder (DCD) and the lack of a clear research consensus about motor difficulties in ADHD. Despite increasing evidence and diagnostic classifications that define DCD by motor impairment, the role of ADHD symptoms in DCD has not been delineated. Similarly, while ADHD may predispose children to motor problems, it is unclear whether any such motor difficulties observed in this population are inherent to ADHD or are mediated by comorbid DCD. Future research should address the exact nature and long-term consequences of motor impairment in children with ADHD and elucidate effective treatment strategies for these disorders together and apart.
Integrating Lock-Free and Combining Techniques for a Practical and Scalable FIFO Queue

Concurrent FIFO queues can be generally classified into lock-free queues and combining-based queues. Lock-free queues require manual parameter tuning to control the contention level of parallel execution, while combining-based queues encounter a bottleneck of single-threaded sequential combiner executions at a high concurrency level. In this paper, we introduce a different approach using both lock-free techniques and combining techniques synergistically to design a practical and scalable concurrent queue algorithm. As a result, we have achieved high scalability without any parameter tuning: on an 80-thread average throughput in our experimental results, our queue algorithm outperforms the most widely used Michael and Scott queue by 14.3 times, the best-performing combining-based queue by 1.6 times, and the best performing x86-dependent lock-free queue by 1.7 percent. In addition, we designed our algorithm in such a way that the life cycle of a node is the same as that of its element. This has huge advantages over prior work: efficient implementation is possible without dedicated memory management schemes, which are supported only in some languages, may cause a performance bottleneck, or are patented. Moreover, the synchronized life cycle between an element and its node enables application developers to further optimize memory management.
TOXICITY AND RETINAL PENETRATION OF INFLIXIMAB IN PRIMATES

Purpose: To evaluate the retinal penetration and toxicity of two doses of intravitreal infliximab in primates. Methods: Ten marmosets (Callithrix jacchus) were given intravitreal injection of 100 μg or 400 μg of infliximab, and balanced salt solution served as control. At baseline and after 24 hours (5 animals) and 7 days (the other 5), the eyes were examined by electroretinography. They were then killed (at 24 hours and 7 days) and assessed by light microscopy and transmission electron microscopy for toxicity and immunohistochemistry, using a biotinylated anti-human immunoglobulin G, to evaluate retinal penetration. Results: There was no difference over 50% of the electroretinography b-wave between baseline and the time points studied in all animals. Light and electron microscopy, and electroretinography analysis, showed no signs of toxicity in any of the animals. Strong presence of infliximab was observed in all retinal layers 7 days after intravitreal injection at both doses (100 and 400 μg). Conclusion: Infliximab at doses of 100 and 400 μg seemed to cause no damage to the retina 24 hours and 7 days after its intravitreal injection, and deeply penetrated all its layers, in primates. These results encourage future perspectives for the treatment of chronic inflammatory diseases of the retina in humans.
Role of Dendritic Cell Phenotype, Determinant Spreading, and Negative Costimulatory Blockade in Dendritic Cell-Based Melanoma Immunotherapy

MART-127–35-peptide-pulsed immature dendritic cells (DCs) resulted in immunologic and clinical activity in a prior phase 1 trial. A phase 2 cohort expansion was initiated to further characterize the phenotype and cytokine milieu of the DC vaccines and their immunologic activity in vitro and to further examine a possible link between clinical activity and determinant spreading. In an open-label phase 2 trial, 107 autologous ex vivo generated DCs pulsed with the HLA-A*0201 immunodominant peptide MART-127–35 were administered to 10 subjects with stage II–IV melanoma. The experimental vaccines were administered intradermally in a biweekly schedule for a total of three injections, and blood for immunologic assays was obtained before each administration and at three time points after. DC vaccine preparations had wide intra- and interpatient variability in terms of cell surface markers and preferential cytokine milieu, but they did not correlate with the levels of antigen-specific T cells after vaccination. Of four patients with measurable disease, one had stable disease for 6 months and another has a continued complete response for over 2 years, which is confounded by receiving a closely sequenced CTLA4 blocking antibody. The DC vaccines induced determinant spreading in this subject, and CTLA4 blockade reactivated T cells with prior antigen exposure. The DC phenotype and cytokine profile do not correlate with the ability to induce antigen-specific T cells, while determinant spreading after DC immunization may be a marker of an efficient antitumor response. Sequential CTLA4 blockade may enhance the immune activity of DC-based immunotherapy.
Characterisation of pathophysiological function of NEDD4-2 in kidney

I Declaration.IV Publication, Awards and Conference Attendance.V Acknowledgements.VI Abbreviations.IX List of Figures and Tables.XVII Thesis Structure.XX Chapter 1: Introduction.1 1. Ubiquitination . 3 1.1 Ubiquitin activating enzymes (E1) . 4 1.2 Ubiquitin-conjugating enzymes (E2) . 4 1.3 Ubiquitin protein ligases (E3) . 4 1.3. 1 HECT E3s.5 1.3. 2 RING and RING like E3s.5 1.3. 3 Ubiquitination control by DUBs and other mechanisms.6 1.3. 4 Degradation by the proteasome.8 1.3. 5 Degradation by lysosomes.8 2. The NEDD4 family of Ubiquitin ligases.9 3. NEDD4-2 structure and expression . 10 4. NEDD4-2 targets and function. 15 4.1 ENaC regulation by NEDD4-2 . 17 4.2. NEDD4-2 mediated regulation of renal Na + -Cl cotransporter (NCC) . 20 4.3. NEDD4-2 as a regulator of voltage-gated sodium channels (Navs) . 20 4.4. Chloride channels as NEDD4-2 targets . 21 4.5. Potassium channels as putative NEDD4-2 targets . 23 4.6. Surfactant protein C (SP-C) as a NEDD4-2 substrate . 23 4.7. Other channels and transporters.24 4.8. Regulation of TGFβ signalling by NEDD4-2 . 25 4.9. NEDD4-2 in virus budding . 25 4.10. Other substrates of NEDD4-2 . 26 4.11. NEDD4-2 substrate interaction through adaptors . 26 5. NEDD4-2/NEDD4L in human disease . 28 5.1. Hypertension . 28 5.2. Cancer . 29 6. Studies with NEDD4-2 knockout (KO) mice . 30 7. Kidney structure, function and disease . 33 8. Project Aims . 38 Chapter 2: Characterisation of Nedd4-2 -/kidney phenotype.39 2.
Exercise is associated with elevated proinflammatory cytokines in human milk.

OBJECTIVES To explore relationships between self-reported exercise in postpartum women and concentrations of cytokines and secretory immunoglobulin A in their milk. METHOD Fifty-eight frozen, unthawed aliquots of human hindmilk were available for analysis from a previous larger study on the influence of lactation on postpartum stress and immunity. The samples were early-morning, hand-expressed, hindmilk that had been collected between 4 and 6 weeks. Milk cytokines were analyzed by a multiplex assay of 20 cytokines, chemokines, and growth factors. Milk secretory immunoglobulin A was analyzed by enzyme-linked immunosorbent assay. Exercise data were extracted from a demographic questionnaire that was used in the original study and approximate metabolic-equivalent tasks assigned to the exercise levels reported. Based on reported frequency of exercise at a particular metabolic-equivalent task, caloric expenditures were calculated for each mother. RESULTS With increasing metabolic-equivalent tasks, and thus caloric expenditures, proinflammatory cytokines increased in mothers' milk. Secretory immunoglobulin A concentrations were not affected by mother's exercise. CONCLUSIONS There are several possible interpretations for these results. These data are preliminary, and a larger, longitudinal study with a more structured exercise instrument will clarify if recommendations should be made about heavy exercise in the early postpartum months.
Assessment and monitoring of biologic drug adverse events in patients with psoriasis

Background Current treatment guidelines for biologic therapies in psoriasis differ in their recommendation for the monitoring of adverse events. Objective The aim of this paper was to draw together evidence from the currently available guidelines as a summary of how biologics licensed for the treatment of psoriasis should be monitored for adverse events. Methods The MEDLINE database was searched to identity the current literature on the safety and screening guidance associated with infliximab, etanercept, adalimumab, ustekinumab, and secukinumab. Limitations This study was limited by the lack of data evaluating monitoring in patients with psoriasis undergoing treatment with a biologic therapy. Results This review of the current literature highlights that there are areas of routine screening, which are recommended in current practice, which require further evidence to investigate its true utility. Conclusion Most screening and monitoring tests performed routinely in clinical practice are supported by minimal clinical evidence, highlighting the need for more studies to evaluate the role and value of the different modalities of screening and monitoring for adverse events in those with psoriasis receiving treatment with biologic therapies.
Dependency Parsing with Undirected Graphs

We introduce a new approach to transition-based dependency parsing in which the parser does not directly construct a dependency structure, but rather an undirected graph, which is then converted into a directed dependency tree in a post-processing step. This alleviates error propagation, since undirected parsers do not need to observe the single-head constraint. Undirected parsers can be obtained by simplifying existing transition-based parsers satisfying certain conditions. We apply this approach to obtain undirected variants of the planar and 2-planar parsers and of Covington's non-projective parser. We perform experiments on several datasets from the CoNLL-X shared task, showing that these variants outperform the original directed algorithms in most of the cases.
Salivary Biomarkers to Assess Breast Cancer Diagnosis and Progression: Are We There Yet?

Technological developments are propelling medical diagnostics forward at unprecedented rates. Advancements in genomic, proteomics and cellomics are leading the way for diagnostic tests that will be capable of rapid multi-analyte detection in both laboratory and non-laboratory settings. Currently, proof-of-principle has been demonstrated for salivary biomarkers, whose up and down regulation has been shown to correlate strongly with breast cancer among women. Consequently, the rationale for this chapter is to review the medical literature and present the current research focused on the use of saliva as a diagnostic medium for the study of early breast cancer progression.
On Achieving Optimal Rate of Digital Precoder by RF-Baseband Codesign for MIMO Systems

For many communications systems, such as the one for millimeter-wave communications, the design of the precoder that multiplexes independent data streams in space is subject to the unconventional constraint that the numbers of the available frequency converters and digital-to-analog (D/A) converters are only a fraction of the number of equipped antennas. In this paper, we study the joint design of both radio-frequency (RF) and baseband signal processing, where the RF signal processing is implemented by phase shifters with variable phase shifts. We propose two hybrid precoder designs that provide the same achievable rate as the optimal fully-digital precoder. The first design is the generalization of the optimal single-stream scheme developed by Zhang, Molisch, and Kung. The second design is obtained by simplifying the first design with simplification process that involves a new decomposition of the optimal unconstrained precoding matrix and the rearrangement of the separation of the baseband and RF circuits. The comparison of system complexity in terms of the numbers of required D/A converters, frequency converters, and phase shifters is provided and the performance of the proposed designs is verified by simulations.
Perifoveal Microcirculation in Macular Oedema with Retinal Vein Occlusion

Central retinal vein occlusion (CRVO) is a common retinal vascular disease that often results in macular oedema, which is the most frequent cause of visual impairment in these patients [1]. Therefore, it is important to understand the vascular and haemodynamic abnormalities that underlie the progression of macular oedema in CRVO. Remky et al. [2] found that the perifoveal blood flow velocity (BFV) was significantly reduced in CRVO patients compared with healthy subjects by using scanning laser ophthalmoscopy with fluorescein angiography (FA) to measure BFV in the perifoveal capillaries based on the movement of fluorescent dots. However, the relationship between perifoveal BFV and macular oedema in CRVO patients remains unclear. Accordingly, we investigated the relation between perifoveal capillary BFV and retinal thickness at the central fovea in CRVO patients with macular oedema, healthy volunteers, and patients who had branch retinal vein occlusion (BRVO) with macular oedema [3].
Representations of the Fundamental Group of an $L$ –Punctured Sphere Generated by Products of Lagrangian Involutions

Abstract In this paper, we characterize unitary representations of $\pi \text{ }:=\text{ }\pi {{\text{ }}_{1}}({{S}^{2}}\backslash \{{{s}_{1}},\ldots ,{{s}_{l}}\})$ whose generators ${{u}_{1}},\,\ldots ,\,{{u}_{l}}$ (lying in conjugacy classes fixed initially) can be decomposed as products of two Lagrangian involutions ${{u}_{j}}\,=\,{{\sigma }_{j}}{{\sigma }_{j+1}}$ with ${{\sigma }_{l+1}}\,=\,{{\sigma }_{1}}$ . Our main result is that such representations are exactly the elements of the fixed-point set of an anti-symplectic involution defined on the moduli space ${{\mathcal{M}}_{C}}\,:\,=\,\text{Ho}{{\text{m}}_{C}}(\pi ,\,U(n))\,/\,U(n)$ . Consequently, as this fixed-point set is non-empty, it is a Lagrangian submanifold of ${{\mathcal{M}}_{C}}$ . To prove this, we use the quasi-Hamiltonian description of the symplectic structure of ${{\mathcal{M}}_{C}}$ and give conditions on an involution defined on a quasi-Hamiltonian $U$ -space $(M,\,\omega ,\,\mu :\,M\to \,U)$ for it to induce an anti-symplectic involution on the reduced space $M//U:=\,{{\mu }^{-1}}\,(\{1\})/U$ .