Miracle-dz/UniFAR-FTUs huggingface dataset:
Transient Receptor Potential Channels Encode Volatile Chemicals Sensed by Rat Trigeminal Ganglion Neurons

Primary sensory afferents of the dorsal root and trigeminal ganglia constantly transmit sensory information depicting the individual’s physical and chemical environment to higher brain regions. Beyond the typical trigeminal stimuli (e.g. irritants), environmental stimuli comprise a plethora of volatile chemicals with olfactory components (odorants). In spite of a complete loss of their sense of smell, anosmic patients may retain the ability to roughly discriminate between different volatile compounds. While the detailed mechanisms remain elusive, sensory structures belonging to the trigeminal system seem to be responsible for this phenomenon. In order to gain a better understanding of the mechanisms underlying the activation of the trigeminal system by volatile chemicals, we investigated odorant-induced membrane potential changes in cultured rat trigeminal neurons induced by the odorants vanillin, heliotropyl acetone, helional, and geraniol. We observed the dose-dependent depolarization of trigeminal neurons upon application of these substances occurring in a stimulus-specific manner and could show that distinct neuronal populations respond to different odorants. Using specific antagonists, we found evidence that TRPA1, TRPM8, and/or TRPV1 contribute to the activation. In order to further test this hypothesis, we used recombinantly expressed rat and human variants of these channels to investigate whether they are indeed activated by the odorants tested. We additionally found that the odorants dose-dependently inhibit two-pore potassium channels TASK1 and TASK3 heterologously expressed In Xenopus laevis oocytes. We suggest that the capability of various odorants to activate different TRP channels and to inhibit potassium channels causes neuronal depolarization and activation of distinct subpopulations of trigeminal sensory neurons, forming the basis for a specific representation of volatile chemicals in the trigeminal ganglia.
Glutamate Potentiates the Toxicity of Mutant Cu/Zn-Superoxide Dismutase in Motor Neurons by Postsynaptic Calcium-Dependent Mechanisms

Mutations in the Cu/Zn-superoxide dismutase (SOD-1) gene are responsible for a subset of familial cases of amyotrophic lateral sclerosis. Using a primary culture model, we have demonstrated that normally nontoxic glutamatergic input, particularly via calcium-permeable AMPA/kainate receptors, is a major factor in the vulnerability of motor neurons to the toxicity of SOD-1 mutants. Wild-type and mutant (G41R, G93A, or N139K) human SOD-1 were expressed in motor neurons of dissociated cultures of murine spinal cord by intranuclear microinjection of plasmid expression vector. Both a general antagonist of AMPA/kainate receptors (CNQX) and a specific antagonist of calcium-permeable AMPA receptors (joro spider toxin) reduced formation of SOD-1 proteinaceous aggregates and prevented death of motor neurons expressing SOD-1 mutants. Partial protection was obtained by treatment with nifedipine, implicating Ca2+ entry through voltage-gated calcium channels as well as glutamate receptors in potentiating the toxicity of mutant SOD-1 in motor neurons. Dramatic neuroprotection was obtained by coexpressing the calcium-binding protein calbindin-D28k but not by increasing intracellular glutathione levels or treatment with the free radical spin trap agent, N-tert-butyl-α-phenylnitrone. Thus, generalized oxidative stress could have contributed in only a minor way to death of motor neurons expressing the mutant SOD-1. These studies demonstrated that the toxicity of these mutants is calcium-dependent and provide direct evidence that calcium entry during neurotransmission, coupled with deficiency of cytosolic calcium-binding proteins, is a major factor in the preferential vulnerability of motor neurons to disease.
Robust Translation of γ-Secretase Modulator Pharmacology across Preclinical Species and Human Subjects

The amyloid-β peptide (Aβ)—in particular, the 42–amino acid form, Aβ1-42—is thought to play a key role in the pathogenesis of Alzheimer’s disease (AD). Thus, several therapeutic modalities aiming to inhibit Aβ synthesis or increase the clearance of Aβ have entered clinical trials, including γ-secretase inhibitors, anti-Aβ antibodies, and amyloid-β precursor protein cleaving enzyme inhibitors. A unique class of small molecules, γ-secretase modulators (GSMs), selectively reduce Aβ1-42 production, and may also decrease Aβ1-40 while simultaneously increasing one or more shorter Aβ peptides, such as Aβ1-38 and Aβ1-37. GSMs are particularly attractive because they do not alter the total amount of Aβ peptides produced by γ-secretase activity; they spare the processing of other γ-secretase substrates, such as Notch; and they do not cause accumulation of the potentially toxic processing intermediate, β-C-terminal fragment. This report describes the translation of pharmacological activity across species for two novel GSMs, (S)-7-(4-fluorophenyl)-N2-(3-methoxy-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl)-N4-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine (BMS-932481) and (S,Z)-17-(4-chloro-2-fluorophenyl)-34-(3-methyl-1H-1,2,4-triazol-1-yl)-16,17-dihydro-15H-4-oxa-2,9-diaza-1(2,4)-cyclopenta[d]pyrimidina-3(1,3)-benzenacyclononaphan-6-ene (BMS-986133). These GSMs are highly potent in vitro, exhibit dose- and time-dependent activity in vivo, and have consistent levels of pharmacological effect across rats, dogs, monkeys, and human subjects. In rats, the two GSMs exhibit similar pharmacokinetics/pharmacodynamics between the brain and cerebrospinal fluid. In all species, GSM treatment decreased Aβ1-42 and Aβ1-40 levels while increasing Aβ1-38 and Aβ1-37 by a corresponding amount. Thus, the GSM mechanism and central activity translate across preclinical species and humans, thereby validating this therapeutic modality for potential utility in AD.
Job Embeddedness and Subjective Norms in an East Asian (Korean) Context

This study is about the effects of job embeddedness and subjective norms on the intent to quit. The main argument on job embeddedness is that the higher the job embeddedness, the less people think about leaving a job. Many researchers have been interested in the topic, “Job embbeddedness” and have conducted empirical research since 2001. This study replicated the work of Mitchell et al. (2001b) and found that job embeddedness is a meaningful construct in Korea, especially on-the-job embeddedness dimensions. However, it gives some concerns on off-the-job embeddedness construct and we suggest that subjective norms are more meaningful in terms of non-job factors in an East Asian (Korean) context.
Biodegradable Poly(Lactic Acid)/Multiwalled Carbon Nanotube Nanocomposite Fabrication Using Casting And Hot Press Techniques

Biodegradable advanced polymer composites have recently received a large amount of attention. The present study aimed to design poly(lactic acid) multiwalled carbon nanotube nanocomposites (PLA/MWCNTs) using a simple fabrication technique. A PLA sheet was first dissolved in dichloromethane, and MWCNTs were subsequently added at various concentrations (0.5, 1.5 and 5%) while applying shear strain stirring to achieve dispersion of carbon nanotubes (CNTs). These solutions were then molded and a hot press was used to generate sheets free of voids with entrapped solvent. The prepared samples were characterized using field emission scanning electron microscopy (FE-SEM), x-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and thermogravimetric analysis (TGA). Our data showed composite samples free of defects and voids, indicating that the hot press is capable of generating sufficiently compact polymer matrices. Additionally, TGA and FTIR showed significant bonding interactions between the PLA matrix and the nano-fillers. Collectively, our results suggest that incorporation of CNTs as nano-fillers into biodegradable polymers may have multiple applications in many different sectors.
Effects of solar ultraviolet radiation on terrestrial ecosystems. Patterns, mechanisms, and interactions with climate change

Ultraviolet radiation (UV) is a minor fraction of the solar spectrum reaching the ground surface. In this assessment we summarize the results of previous work on the effects of the UV-B component (280-315 nm) on terrestrial ecosystems, and draw attention to important knowledge gaps in our understanding of the interactive effects of UV radiation and climate change. We highlight the following points: (i) The effects of UV-B on the growth of terrestrial plants are relatively small and, because the Montreal Protocol has been successful in limiting ozone depletion, the reduction in plant growth caused by increased UV-B radiation in areas affected by ozone decline since 1980 is unlikely to have exceeded 6%. (ii) Solar UV-B radiation has large direct and indirect (plant-mediated) effects on canopy arthropods and microorganisms. Therefore, trophic interactions (herbivory, decomposition) in terrestrial ecosystems appear to be sensitive to variations in UV-B irradiance. (iii) Future variations in UV radiation resulting from changes in climate and land-use may have more important consequences on terrestrial ecosystems than the changes in UV caused by ozone depletion. This is because the resulting changes in UV radiation may affect a greater range of ecosystems, and will not be restricted solely to the UV-B component, (iv) Several ecosystem processes that are not particularly sensitive to UV-B radiation can be strongly affected by UV-A (315–400 nm) radiation. One example is the physical degradation of plant litter. Increased photodegradation (in response to reduced cloudiness or canopy cover) will lead to increased carbon release to the atmosphere via direct and indirect mechanisms.
NON-ADOPTION OF THE INTERNET IN GREAT BRITAIN AND SWEDEN

Non-use of the Internet has often been researched within the topic of digital divides. The focus of these studies lay mainly on differences in socio-economic backgrounds and resources. This paper goes one step further by attempting to describe various groups of non-users in two highly developed European countries: Great Britain and Sweden. Results from descriptive analyses, multivariate regressions, and principal components analysis with two waves of comparable data from 2007 and 2009 show a more heterogeneous non-user population in Great Britain and a slightly more homogeneous one in Sweden. Socio-economic factors play a bigger role in influencing who is going online in Britain than in Sweden. Education, occupational status, and household income are significant determinants in both countries. The most important determinants of Internet adoption are age and occupational status. The analysis of a 25–55-year-old sub-sample shows that non-users from this age group feature different socio-economic characteristics from older age groups. Middle-aged British non-users share two specific socio-economic characteristics: low income and unemployment; 25–55-year-old Swedish non-users tend to have low incomes, be unemployed, and be single. Non-users' self-assessment of reasons for non-use do not seem to be consistent with the ‘raw data’. Non-users mainly state that they are not interested in the Internet. Many non-users share sceptical attitudes about the Internet, which influences interest in them. There needs to be more detailed research to know exactly which people are not using the Internet and why.
Financial Infidelity- Secret Saving Behavior of the Individual

Financial infidelity is the cheating that the spouse make with their partner regarding financial matters. This issue has been into picture since long as we see many couples cheat their partner in money matters regularly around us. This paper attempts to develop the understanding of the influence of the demographic factors on the financial habits particularly infidelity of the respondents. For this the researcher has made the survey of 100 respondents in the area of Ahemdabad city through the structured questionnaire. Data were analyzed using reliability test, T-test as well as Anova techniques. The findings of this study could help the financial consultant in helping their clients achieve financial goals and decide their financial priorities accordingly by disclosing the saving habits of the clients. At the end of the paper suggestion is given regarding how to deal with financial infidelity and ways to overcome it.
Predictors of Academic Achievement and Failure Among Low-Income Urban African American Adolescents: An Ecological Perspective

viii CHAPTER I: INTRODUCTION . 1 Background . 3 Ecological Theory . 4 Overview of Factors . 6 Factors in Interaction . 8 Academic Resilience . 9 Risk Factors . 11 Protective Factors. 19 Optimal Data Analysis . 24 The Current Study . 25 Research Questions . 25 Hypotheses . 26 CHAPTER II: METHOD . 27 Participants . 27 Procedure . 28 Measures . 39 Data Analysis . 43 CHAPTER III: RESULTS . 47 Descriptive Statistics . 47 ODA Results . 47 CHAPTER IV: DISCUSSION . 91 Mathematic Achievement . 91 Reading Achievement . 94 Initial Hypotheses . 97 Overall Findings Within an Ecological Systems Framework . 99 Mathematic Versus Reading Achievement . 102 School Attributes . 103 The Role of School . 104 Strengths and Limitations of the Current Study . 106 Conclusion . 109
An exploration of university physics students' epistemological mindsets towards the understanding of physics equations

Students’ attitudes and beliefs about learning have been shown to affect learning outcomes. This study explores how university physics students think about what it means to understand physics equations. The data comes from semi-structured interviews with students from three Swedish universities. The analysis follows a data-based, inductive approach to characterise students’ descriptions of what it means to understand equations in terms of epistemological mindsets (perceived critical attributes of a learning, application, or problem-solving situation that are grounded in epistemology). The results are given in terms of different components of students’ epistemological mindsets. Relations between individuals and sets of components as well as differences across various stages of students’ academic career are then explored. Pedagogical implications of the findings are discussed and tentative suggestions for university physics teaching are made.
Interacting dimensions of diversity: Cross-categorization and the functioning of diverse work groups

We conducted an experiment to show how the interplay between informational diversity and other dimensions of diversity can account for some of the inconsistent effects of informational diversity in previous research. 70 four-person groups involved in a decision-making task received homogeneous or heterogeneous information. By manipulating gender composition and bogus personality feedback we created groups that either had a potential faultline (a basis for subgroup categorization) or were homogeneous on these dimensions. In potential faultline groups, heterogeneity of information either converged with or cross-cut the other dimensions of diversity. Results showed that informational diversity enhanced group functioning when it was crossed rather than converged with the potential faultline.
Occupational asthma and work-exacerbated asthma: factors associated with time to diagnostic steps.

BACKGROUND Little is known regarding the factors associated with the times for patients' first physician visit, the first physician suspicion of work-related asthma (WRA), and final diagnosis after the onset of WRA symptoms. This study examined individual and work-related factors that are associated with longer times to these diagnostic milestones among groups with occupational asthma (OA) and work-exacerbated asthma (WEA). METHOD Suspected WRA cases were identified from an occupational lung disease clinic and claimants to the Ontario Workplace Safety and Insurance Board (100 patients each). Questionnaire administration and chart review were undertaken. RESULTS Eighty participants were classified as having sensitizer-induced OA and 87 as having WEA. For the OA group, the risk factors for delay included male sex, being unmarried, low education, and lack of awareness of association of symptoms with work. Other factors included older age, being the sole income earner, and lack of knowledge of the Workplace Hazardous Materials Information System program. For WEA, lower household income, lower education, absence of a health-and-safety program at work, absence of a union, and lack of awareness of OA and of agents at work that could affect asthma significantly increased the time to diagnostic milestones. CONCLUSIONS Different factors affect the diagnostic milestones for OA and WEA. Findings suggest a need for educational programs for workers who are at risk of OA and WEA and a need for further primary care physician education on WRA.
A multimodel examination of climate extremes in an idealized geoengineering experiment

Temperature and precipitation extremes are examined in the Geoengineering Model Intercomparison Project experiment G1, wherein an instantaneous quadrupling of CO2 from its preindustrial control value is offset by a commensurate reduction in solar irradiance. Compared to the preindustrial climate, changes in climate extremes under G1 are generally much smaller than under 4 × CO2 alone. However, it is also the case that extremes of temperature and precipitation in G1 differ significantly from those under preindustrial conditions. Probability density functions of standardized anomalies of monthly surface temperature T and precipitation P in G1 exhibit an extension of the high‐ T tail over land, of the low‐ T tail over ocean, and a shift of P to drier conditions. Using daily model output, we analyzed the frequency of extreme events, such as the coldest night (TNn), warmest day (TXx), and maximum 5 day precipitation amount, and also duration indicators such as cold and warm spells and consecutive dry days. The strong heating at northern high latitudes simulated under 4 × CO2 is much alleviated in G1, but significant warming remains, particularly for TNn compared to TXx. Internal feedbacks lead to regional increases in absorbed solar radiation at the surface, increasing temperatures over Northern Hemisphere land in summer. Conversely, significant cooling occurs over the tropical oceans, increasing cold spell duration there. Globally, G1 is more effective in reducing changes in temperature extremes compared to precipitation extremes and for reducing changes in precipitation extremes versus means but somewhat less effective at reducing changes in temperature extremes compared to means.
Categorical Data Analysis, 3rd Edition Extra Exercises

This file contains extra exercises. Most of these were in the first or second edition of the text, did not fit in the 3rd edition. They are organized by chapter. Instructors are welcome to use them for homeworks or exams. 1. In the following examples, identify the response variable and the explanatory variables. 2. Which measurement scale is most appropriate for attitude toward legalization of abortion (disapprove always, approve in certain cases, approve always). 3. Describe a potential study with a categorical response variable. List explanatory variables that would be important. For each variable, identify the measurement scale, and indicate whether to treat it as continuous or discrete, quantitative or qualitative. 4. In a large city, 50% of the population is black. Prospective jurors for court trials are selected from this population. For each selection of a juror, π denotes the probability that a black person is selected. A supposedly random sampling of 12 prospective jurors contains 1 black person. Using the exact binomial test, find the P-value for testing H 0 : π = 0.5 against H a : π = 0.5. 5. A sample of 100 adults suffer from migraine headaches. A new analgesic is claimed to provide greater relief than a standard one. After using each analgesic in a crossover experiment, 40 reported greater relief with the standard analgesic and 60 reported greater relief with the new one. Analyze these data.
Attributional Style as a Predictor of Academic Success for Students with Learning Disabilities and Attention Deficit Disorder in Postsecondary Education

Thirty one students with learning disabilities (LD) and/or with Attention Deficit Hyperactivity Disorder (ADHD) completed a combined Academic Attributional Style and Coping with Academic Failures Questionnaire. The reformulated learned helplessness model (Abramson, Seligman, & Teasdale, 1978) predicted that students with negative attributional styles (i.e., internal-stable-global attributions) experienced motivational, cognitive, and emotional deficits. The present study examined college achievement (grade point average) of students with LD and/or ADHD. The Prediction that students with LD and/or ADHD with negative attributional styles would achieve less academic success than comparable students with positive attributional styles (i.e., extenal-unstable-specific attributions) was supported by the research results.
Safer sex behavior: The role of attitudes, norms and control factors

A study was undertaken to assess the utility of revisions to the theories of reasoned actiodplanned behavior in the context of HIV-preventive behaviors. Revisions to the models incorporated the addition of group norm (behavioral norm and group attitude) to the nonnative component of the reasoned action model and the distinction among three aspects (self-efficacy, perceived behavioral control, and planning) of the control component of the theory of planned behavior. Respondents were 2 11 sexually experienced heterosexual undergraduates. The study employed a longitudinal design, with the proposed predictors of performing the behaviors under consideration (using a condom every time you have sexual intercourse during the next month and discussing whether to use a condom with any new partners during the next month) assessed prior to the measures of reported behavior. Consistent with expectations, group norm emerged as a distinctive predictor (in addition to attitude and subjective norm) of intentions to practice both safer sex behaviors. The data also revealed some support for the distinction among the different measures of control. The results of the study suggest that the normative component of the theories of reasoned action and planned behavior should be revised to incorporate more subtle influences of the referent group and that tests of theory of planned behavior should distinguish among the different aspects of behavioral control.