Miracle-dz/UniFAR-FTUs huggingface dataset:
An Electroencephalography Network and Connectivity Analysis for Deception in Instructed Lying Tasks

Deception is an impactful social event that has been the focus of an abundance of researches over recent decades. In this paper, an electroencephalography (EEG) study is presented regarding the cognitive processes of an instructed liar/truth-teller during the time window of stimulus (question) delivery period (SDP) prior to their deceptive/truthful responses towards questions related to authentic (WE: with prior experience) and fictional experience (NE: no prior experience). To investigate deception in non-experienced events, the subjects were given stimuli in a mock interview scenario that induced them to fabricate lies. To analyze the data, frequency domain network and connectivity analysis was performed in the source space in order to provide a more systematic level understanding of deception during SDP. This study reveals several groups of neuronal generators underlying both the instructed lying (IL) and the instructed truth-telling (IT) conditions for both tasks during the SDP. Despite the similarities existed in these group components, significant differences were found in the intra- and inter-group connectivity between the IL and IT conditions in either task. Additionally, the response time was found to be positively correlated with the clustering coefficient of the inferior frontal gyrus (44R) in the WE-IL condition and positively correlated with the clustering coefficient of the precuneus (7L) and the angular gyrus (39R) in the WE-IT condition. However, the response time was found to be marginally negatively correlated with the clustering coefficient of the secondary auditory cortex (42L) in the NE-IL condition and negatively correlated with the clustering coefficient of the somatosensory association cortex (5L, R) in the NE-IT condition. Therefore, these results provide complementary and intuitive evidence for the differences between the IL and IT conditions in SDP for two types of deception tasks, thus elucidating the electrophysiological mechanisms underlying SDP of deception from regional, inter-regional, network, and inter-network scale analyses.
Rethinking cataract surgery benchmarking, key performance indicators and maintaining professional standards in Australia

We were pleasantly surprised and indeed encouraged to read the Editorial by Dr Sukhpal Sandhu of the Royal Victorian Eye and Ear Hospital, Centre for Eye Research Australia. This is related to our article from 1993 documenting the surgical and postoperative experience of one surgeon’s first 100 cataract procedures. Dr Sandhu felt that it was perhaps the first of its kind. It was certainly a ‘belt and braces’ report, as phacoemulsification was relatively new to Australia at that time, and most experienced cataract surgeons were attending courses and observing their colleagues, both locally and overseas, in order to hone their skills in this technique. In the study quoted, the complication rate was, by today’s standards, unacceptable. However, the way forward was clear, and the surgeon in question has todateperformed5324endocapsularphacoemulsification procedures. The number of cases in this cohort may be seen by some ophthalmic surgeons as somewhat unremarkable in terms of volume. According to documentation of our last 1382 cases, studied prospectively and consecutively, with no exclusions, and one month follow up in 100% of cases, the corrected distance visual acuity (CDVA) was 6/4 in 92.3% of cases. While the authors acknowledge that some of these may have been relatively straightforward surgical cases, many surgeons find that the more difficult cases are actually easier to operate on. This is because the cataract nuclei are more easily managed with standard sculpting followed by phaco stop-and-chop. This particularly applies to nuclear sclerosis grades 2+ to 3+ or more. It has been said that it is essential to document surgical outcomes for any practising surgeon. While patients want to see well, preferably without glasses, and patient satisfaction is important, the definitive outcome should be quantifiable and focus on visual outcomes (VOs). To that end, documenting the VO (as CDVA) at each relevant time point is central, and we applaud Dr Sandhu for his Editorial. Furthermore, the notion of transparency is also critical, because the ‘feel good’ response by the patient may simply reflect the fact that a 6/60 eye now sees 6/12. This particularly applies to a recent article in the German literature, in which patient satisfaction was measured as a score out of 10, apparently minimally related to final CDVA. While patient satisfaction should be regarded as important, our group feels that surgeons need to have an objective measure of success. This also permits investigators and insurance providers to compare the visual outcomes between cataract surgeons reliably and readily. Our group considers that the mandatory logbooks issued by RANZCO for trainees in ophthalmology are an excellent tool in promoting satisfactory VOs. Indeed, our group believes that a case could be made for all cataract surgeons to document fully the preoperative, operative and postoperative findings for every patient.
SPECT imaging in head injury interpreted with statistical parametric mapping.

UNLABELLED This study investigated regional cerebral blood flow in head-injured patients using statistical parametric mapping (SPM) to detect hypoperfusion on (99m)Tc-hexamethylpropyleneamine oxime (HMPAO) SPECT scans. METHODS Acute and follow-up SPECT and MRI scans from 61 patients who were admitted to a regional neurosurgical unit were examined. Patients had acute MRI and SPECT at 2-18 d after injury and on follow-up between 130 and 366 d after injury. Thirty-two scans from non-head-injured patients were used as a SPECT control group. The SPECT images were first aligned to the Talairach-Tournoux atlas and then analyzed statistically with SPM. RESULTS SPECT detected more extensive abnormality than MRI in acute and follow-up stages. This effect was more pronounced on follow-up of patients with diffuse injury. Examination of a focal injury group indicated the involvement of frontal and temporal lobes and the anterior cingulate. Blood flow abnormalities persist, to a lesser extent, on follow-up scans. The diffuse group displayed low blood flow in the frontal and temporal lobes, including cingulate involvement, which persists at follow-up with additional involvement of the thalamus. CONCLUSION SPM has a role in SPECT image interpretation because it allows better visualization than other methods of quantitative analysis of the spatial distribution of abnormalities in focal and diffuse head injury. Frontal lobe blood flow abnormality (particularly anterofrontal regions and mesiofrontal areas) is common after head injury.
Estimation of a numerical value for joint damage-related physical disability in rheumatoid arthritis clinical trials

Background Joint damage is an important outcome in trials of rheumatoid arthritis (RA), usually assessed by Total Sharp Score (TSS). It is currently unknown how it translates numerically into disability by the Health Assessment Questionnaire (HAQ). Objective To determine the units of HAQ score corresponding to one TSS unit. Methods A short-term observational trial of glucocorticoids in RA (the ‘BEst LIfe with Rheumatoid Arthritis’ (BELIRA) trial) was evaluated, using randomised controlled clinical trial (RCT) data for confirmation. For each trial arm HAQ, TSS and the Simplified Disease Activity Index (SDAI) were assessed. Based on the hypothesis that short-term HAQ changes will mostly be due to changes of disease activity, activity HAQ (ACT-HAQ) at end point (EP) was determined and remaining disability defined as damage related (DAM-HAQ). Using TSS at EP, the HAQ units corresponding to a TSS unit were estimated. Results In BELIRA, one TSS unit corresponded to a mean of 0.017 HAQ units; to account for other causes of irreversible disability, the 25th percentile was used: 0.011 HAQ units/TSS unit. In RCT trial arms, the HAQ/TSS were similar (0.013 and 0.015 in established and early RA, respectively; 25th percentile: 0.010). The correlation between DAM-HAQEP and TSS was r=0.829. Over 5 years, damage would amount to an increase of irreversible HAQ of 0.33 on placebo, 0.13 on disease-modifying antirheumatic drugs (DMARDs) and 0.03 on TNF inhibitors+methotrexate (MTX). Conclusion An approach to estimate the numerical relationship between HAQ and damage as 0.01 HAQ points/TSS unit is presented, although the linear relationship may not be generally valid. This allows the assessment of functional correlates of radiographic changes in trials.
On the Modelling of Imperfect Repairs for a Continuously Monitored Gamma Wear Process Through Age Reduction

A continuously monitored system is considered, which is subject to accumulating deterioration modelled as a gamma process. The system fails when its degradation level exceeds a limit threshold. At failure, a delayed replacement is performed. To shorten the down period, a condition-based maintenance strategy is applied, with imperfect repair. Mimicking virtual age models used for recurrent events, imperfect repair actions are assumed to lower the system degradation through a first-order arithmetic reduction of age model. Under these assumptions, Markov renewal equations are obtained for several reliability indicators. Numerical examples illustrate the behaviour of the system.
Impulsivity and Hopelessness as Predictors of Suicide-Related Ideation among Older Adults

Objective: Research has demonstrated that impulsivity is strongly associated with suicide-related ideation and behaviour among young adults. However, to date, the potential importance of impulsivity as a predictor of suicide-related ideation in later life has yet to be determined. Our study examined impulsivity, hopelessness, depressive symptomatology, and sociodemographic factors vis-à-vis suicide-related ideation among older adults at risk of self-harm. Method: A sample (n = 117) of older adults was recruited from multiple sources for this study over a 1-year period. Suicide-related ideation was measured with the Geriatric Suicide Ideation Scale, a multidimensional measure of suicide-related ideation developed for use with older adults. Results: Canonical correlation identified 2 pairings of linear composites in which impulsivity emerged along both as significantly associated with facets of suicide-related ideation. Of note, the greater proportion of variance in impulsivity was subsumed along the second set of vectors with somatic depressive symptoms. Conclusion: Our findings suggest that the impulse to self-harm may be even more pronounced among older adults less likely to present as typically depressed. It is further suggested that impulsivity is more broadly associated with suicide-related ideation than hopelessness, and that screening for impulsivity as well as hopelessness may increase clinicians' ability to identify older adults at greatest risk of self-harm.
Neuropsychiatric symptoms in people screened positive for dementia in primary care

ABSTRACT Background: Neuropsychiatric symptoms are major determinants for caregiver distress and institutionalization in dementia. Little is known about the prevalence of neuropsychiatric symptoms and their association with use of medication, caregiver distress, and resource utilization in primary care. Methods: We assessed frequency of neuropsychiatric symptoms in a sample retrieved from a primary care intervention study. Patients were screened for dementia by their primary care physicians. A study nurse assessed neuropsychiatric symptoms in 176 patients using the neuropsychiatric inventory (NPI) through face-to-face interviews by proxy during home visits. In addition, data on global cognition (MMSE), quality of life (QoL-AD), resource utilization in dementia (RUD), caregiver distress (BIS), and use of psychotropic medication in patients were obtained. We used linear mixed effect models taking into account the clustering of patients within general physician practices. Results: Clinically relevant neuropsychiatric symptoms (NPI score ≥ 4) occurred in about 53% of the patients. Higher NPI scores were significantly associated with more severe cognitive impairment, higher caregiver distress, and higher utilization of caregiver resources by patients but not with a formal diagnosis of dementia from the primary care physician. Use of antipsychotics was associated with higher NPI scores, particularly in non-psychotic domains. Conclusions: Neuropsychiatric symptoms in a primary care cohort screened positive for dementia were associated with resource utilization and distress of caregivers. In contrast to guideline recommendations, the use of antipsychotics was associated with non-psychotic domains of behavioral symptoms. These findings underscore the relevance of neuropsychiatric symptoms for the design of future interventions in primary care.
Clinical Efficacy and Safety on Combining 20% Trichloroacetic Acid Peel with Topical 5% Ascorbic Acid for Melasma.

Introduction Trichloroacetic Acid (TCA) is a versatile peeling agent for treatment of melasma. However, Post-Inflammatory Hyperpigmentation (PIH) is reported to be the most common side-effect associated with TCA peel. Topical Ascorbic Acid (AA) due to its effect as antioxidant and tyrosinase inhibitor helps to prevent PIH and maintains the response. Aim To assess the clinical efficacy, safety and reduction in Melasma Quality of Life (MELASQOL) on combining 20% TCA peel with 5% ascorbic acid cream in epidermal melasma. Materials and Methods This study was conducted in the Department of Dermatology, Pt. Bhagwat Dayal Sharma University of Health Sciences, Rohtak. This was an open labelled prospective randomized study in which 60 patients of epidermal melasma were enrolled for 12 weeks. Patients were divided into two groups: Combination group received 20% TCA peel every two weeks with once daily 5% ascorbic acid cream and Control group received only 20% TCA peel. Melasma Area Severity Index (MASI) was used for evaluating clinical improvement of melasma. Improvement in Quality Of Life (QoL) was assessed by MELASQOL scale in both groups. Adverse effects were evaluated at each visit. All statistical analysis was carried out with SPSS 20th version. The difference in change in mean MASI scoring and MELASQOL scores between the two groups were analysed using Mann-Whitney test. The side effects between the two groups were compared using Chi-square test. Results The combination group demonstrated a statistically significant improvement in MASI, percentage decrease in MASI and quality of life as compared to control group after treatment. At the baseline there was no statistically significant difference in MASI between the two groups (i.e., MASI in combination group and control group were 23.55±4.61 and 23.613±4.088 respectively). However, it was statistically significant at the end of therapy (i.e., MASI in combination group was 9.50±5.31 and in control group was 15.10±4.44). When the results were analysed in terms of percentage decrease in MASI from baseline, there was statistically significant difference in combination group (i.e., 10.87±4.11) as compared to control group (i.e., 6.3±1.97) after 2nd week of therapy. When the mean MELASQOL scores were compared between the two groups at the end of therapy (i.e., 12 weeks), it was found to be statistically significantly lower in combination group (16.60±8.03) as compared to control group (25.90±8.17). Minor adverse effects like post peel erythema, pruritus, burning and stinging sensation were observed in some of the patients, which didn't necessitate termination of the therapy. Conclusion Combination of 20% TCA peel with topical 5% ascorbic acid is a highly effective, safe and promising therapeutic option in treatment of melasma which significantly improves the QoL.
The Effect of Aesthetic on the Usability of Data Visualization

Aesthetic seems currently under represented in most current data visualization evaluation methodologies. This paper investigates the results of an online survey of 285 participants, measuring both perceived aesthetic as well as the efficiency and effectiveness of retrieval tasks across a set of 11 different data visualization techniques. The data visualizations represent an identical hierarchical dataset, which has been normalized in terms of color, typography and layout balance. This study measured parameters such as speed of completion, accuracy rate, task abandonment and latency of erroneous response. Our findings demonstrate a correlation between latency in task abandonment and erroneous response time in relation to visualization's perceived aesthetic. These results support the need for an increased recognition for aesthetic in the typical evaluation process of data visualization techniques.
Selected line difference in the effects of ethanol dependence and withdrawal on allopregnanolone levels and 5alpha-reductase enzyme activity and expression.

BACKGROUND Allopregnanolone (ALLO) is a progesterone derivative that rapidly potentiates gamma-aminobutyric acid(A) (GABA(A)) receptor-mediated inhibition and modulates symptoms of ethanol withdrawal. Because clinical and preclinical data indicate that ALLO levels are inversely related to symptoms of withdrawal, the present studies determined whether ethanol dependence and withdrawal differentially altered plasma and cortical ALLO levels in mice selectively bred for differences in ethanol withdrawal severity and determined whether the alterations in ALLO levels corresponded to a concomitant change in activity and expression of the biosynthetic enzyme 5alpha-reductase. METHODS Male Withdrawal Seizure-Prone (WSP) and -Resistant (WSR) mice were exposed to 72 hours ethanol vapor or air and euthanized at select times following removal from the inhalation chambers. Blood was collected for analysis of ALLO and corticosterone levels by radioimmunoassay. Dissected amygdala, hippocampus, midbrain, and cortex as well as adrenals were examined for 5alpha-reductase enzyme activity and expression levels. RESULTS Plasma ALLO was decreased significantly only in WSP mice, and this corresponded to a decrease in adrenal 5alpha-reductase expression. Cortical ALLO was decreased up to 54% in WSP mice and up to 46% in WSR mice, with a similar decrease in cortical 5alpha-reductase activity during withdrawal in the lines. While cortical gene expression was significantly decreased during withdrawal in WSP mice, there was a 4-fold increase in expression in the WSR line during withdrawal. Hippocampal 5alpha-reductase activity and gene expression was decreased only in dependent WSP mice. CONCLUSIONS These results suggest that there are line and brain regional differences in the regulation of the neurosteroid biosynthetic enzyme 5alpha-reductase during ethanol dependence and withdrawal. In conjunction with the finding that WSP mice exhibit reduced sensitivity to ALLO during withdrawal, the present results are consistent with the hypothesis that genetic differences in ethanol withdrawal severity are due, in part, to modulatory effects of GABAergic neurosteroids such as ALLO.
The Study of Relationship Between Parenting Styles and Externalizing Symptoms in 7 to 9 Year Old Children

The aim of this study was to investi- gate the relationship between pare- nting styles including authoritarian, authoritative and permissive styles) and child behavioural disorder that have conceptualized as externalizing symptoms (aggressive and role broken behaviour). 273 mothers of 7-9 years old boys fro - m primary schools participated in this study.
Scene modelling, recognition and tracking with invariant image features

We present a complete system architecture for fully automated markerless augmented reality (AR). The system constructs a sparse metric model of the real-world environment, provides interactive means for specifying the pose of a virtual object, and performs model-based camera tracking with visually pleasing augmentation results. Our approach does not require camera pre-calibration, prior knowledge of scene geometry, manual initialization of the tracker or placement of special markers. Robust tracking in the presence of occlusions and scene changes is achieved by using highly distinctive natural features to establish image correspondences.
Thiamine Suppresses Thermal Hyperalgesia, Inhibits Hyperexcitability, and Lessens Alterations of Sodium Currents in Injured, Dorsal Root Ganglion Neurons in Rats

Background:B vitamins can effectively attenuate inflammatory and neuropathic pain in experimental animals, while their efficacy in treating clinical pain syndromes remains unclear. To understand possible mechanisms underlying B vitamin-induced analgesia and provide further evidence that may support the clinical utility of B vitamins in chronic pain treatment, this study investigated effects of thiamine (B1) on the excitability and Na+ currents of dorsal root ganglion (DRG) neurons that have been altered by nerve injury. Methods:Nerve injury was mimicked by chronic compression of DRG in rats. Neuropathic pain was evidenced by the presence of thermal hyperalgesia. Intracellular and patch-clamp recordings were made in vitro from intact and dissociated DRG neurons, respectively. Results:(1) In vivo intraperitoneal administration of B1 (66 mg/kg/day, 10–14 doses) significantly inhibited DRG compression-induced neural hyperexcitability, in addition to suppressing thermal hyperalgesia. (2) In vitro perfusion of B1 (0.1, 1 and 10 mm) resulted in a dose-dependent inhibition of DRG neuron hyperexcitability. In addition, the DRG neurons exhibited size-dependent sensitivity to B1 treatment, i.e., the small and the medium-sized neurons, compared to the large neurons, were significantly more sensitive. (3) Both in vitro (1 mm) and in vivo application of B1 significantly reversed DRG compression-induced down-regulation of tetrodotoxin-resistant but not tetrodotoxin-sensitive Na+ current density in the small neurons. B1 at 1 mm also reversed the compression-induced hyperpolarizing shift of the inactivation curve of the tetrodotoxin-resistant currents and the upregulated ramp currents in small DRG neurons. Conclusion:Thiamine can reduce hyperexcitability and lessen alterations of Na+ currents in injured DRG neurons, in addition to suppressing thermal hyperalgesia.
European Conference on Information Systems ( ECIS ) 2008 Network Structure , ICT Use and Performance Attitudes of Knowledge Workers

In this study, we examine the effect of social network structure and information and communication technologies (ICT) use on performance attitudes of knowledge-intensive workers in dispersed occupational communities. We first develop a theoretical framework and use it to develop a valid and reliable survey instrument. Secondly, we apply structural hole measures (constraint and efficiency) for exploring the association with ICT use and attitudes to performance. Empirical results suggest that density of knowledge workers’ professional network is positively associated with ICT use whereas network efficiency is negatively correlated with ICT use at both task and communication-structure level. The findings show that social network structure measures of density, efficiency and constraint are important factors that influence patterns and frequency of ICT use by knowledge workers rather than attitudes to performance.