Miracle-dz/UniFAR-FTUs huggingface dataset:
Negating Stereotype Threat: Autonomy Support and Academic Identification Boost Performance of African American College Students

Abstract:Using a 2 × 2 factorial design, we examined the effects of stereotype threat and autonomy support on the test performance of 190 African American college students. Participants completed a set of 7 easy and 7 difficult problems from Raven’s Progressive Matrices and a survey including measures of Academic Self-Concept, Learning Climate, and Perceptions of Stereotype Threat. ANOVA results revealed that among African American men, those who had a stronger academic identification performed worse than those with a weaker identification; however, the reverse was true among African American women, as those who had stronger academic identification performed better than those with a weaker identification. Finally, both stereotype threat and autonomy support improved test performance for all participants (on easy items), except when women received both conditions. Our results indicate that the deleterious effect of stereotype threat is not consistent, and that performance may be boosted by providing greater autonomy support and strengthening academic identification (especially for female African American students).
Interpreting melanin-based coloration through deep time: a critical review

Colour, derived primarily from melanin and/or carotenoid pigments, is integral to many aspects of behaviour in living vertebrates, including social signalling, sexual display and crypsis. Thus, identifying biochromes in extinct animals can shed light on the acquisition and evolution of these biological traits. Both eumelanin and melanin-containing cellular organelles (melanosomes) are preserved in fossils, but recognizing traces of ancient melanin-based coloration is fraught with interpretative ambiguity, especially when observations are based on morphological evidence alone. Assigning microbodies (or, more often reported, their ‘mouldic impressions’) as melanosome traces without adequately excluding a bacterial origin is also problematic because microbes are pervasive and intimately involved in organismal degradation. Additionally, some forms synthesize melanin. In this review, we survey both vertebrate and microbial melanization, and explore the conflicts influencing assessment of microbodies preserved in association with ancient animal soft tissues. We discuss the types of data used to interpret fossil melanosomes and evaluate whether these are sufficient for definitive diagnosis. Finally, we outline an integrated morphological and geochemical approach for detecting endogenous pigment remains and associated microstructures in multimillion-year-old fossils.
Area-Based Socioeconomic Position and Adult Glioma: A Hierarchical Analysis of Surveillance Epidemiology and End Results Data

Background Glioma rates vary by demographic factors and geo-political boundaries and this variation suggests higher glioma rates in groups of higher socioeconomic position. The primary goal of this analysis is to investigate the relationship between glioma and county socioeconomic position using U.S. Surveillance Epidemiology and End Results (SEER) data. Methods Cases were individuals 25+ years diagnosed with glioma between 2000 and 2006 and residing within the SEER-17 catchment area. County-, sex-, race-, age-specific rates were created in order to investigate individual-level associations (population data from U.S. Census 2000). A Bayesian hierarchical Poisson spatial conditionally autoregressive (CAR) model was utilized to simultaneously estimate individual- and county-level associations while controlling for county spatial dependence. Results Those residing in counties of the second, third, and fourth highest quartiles of socioeconomic position have glioma incidence rates that are 1.10 (95% CI: 1.02,1.19), 1.11 (95% CI: 1.02,1.20), 1.14 (95% CI: 1.05,1.23) times that of the first quartile, respectively. A CAR model properly controlled for error spatial dependence. Investigated lag times suggest year 2000 census data yields superior model fit. Conclusion Demographically adjusted rates of glioma are elevated in counties of higher socioeconomic position. More well-grounded theory concerning the glioma-socioeconomic position association along with socioeconomic data collected at multiple levels is recommended for future studies investigating this relationship.
Programmed cell death in the developing inner ear is balanced by nerve growth factor and insulin-like growth factor I

Nerve growth factor induces cell death in organotypic cultures of otic vesicle explants. This cell death has a restricted pattern that reproduces the in vivo pattern of apoptosis occurring during inner ear development. In this study, we show that binding of nerve growth factor to its low affinity p75 neurotrophin receptor is essential to achieve the apoptotic response. Blockage of binding to p75 receptor neutralized nerve-growth-factor-induced cell death, as measured by immunoassays detecting the presence of cytosolic oligonucleosomes and by TUNEL assay to visualize DNA fragmentation. Nerve growth factor also induced a number of cell-death-related intracellular events including ceramide generation, caspase activation and poly-(ADP ribose) polymerase cleavage. Again, p75 receptor blockade completely abolished all of these effects. Concerning the intracellular pathway, ceramide increase depended on initiator caspases, whereas its actions depended on both initiator and effector caspases, as shown by using site-specific caspase inhibitors. Conversely, insulin-like growth factor I, which promotes cell growth and survival in the inner ear, abolished apoptosis induced by nerve growth factor. Insulin-like growth factor cytoprotective actions were accomplished, at least in part, by decreasing endogenous ceramide levels and activating Akt. Taken together, these results strongly suggest that regulation of nerve-growth-factor-induced apoptosis in the otocysts occurs via p75 receptor binding and is strictly controlled by the interaction with survival signalling pathways.
MicroRNA miR-24 enhances tumor invasion and metastasis by targeting PTPN9 and PTPRF to promote EGF signaling

Summary MicroRNAs are known to play regulatory roles in gene expression associated with cancer development. We analyzed levels of the microRNA miR-24 in patients with breast carcinoma and found that miR-24 was higher in breast carcinoma samples than in benign breast tissues. We generated constructs expressing miR-24 and studied its functions using both in vitro and in vivo techniques. We found that the ectopic expression of miR-24 promoted breast cancer cell invasion and migration. In vivo experiments in mice indicated that the expression of miR-24 enhanced tumor growth, invasion into local tissues, metastasis to lung tissues and decreased overall mouse survival. In the miR-24-expressing cells and tumors, EGFR was highly phosphorylated, whereas expression of the phosphatases tyrosine-protein phosphatase non-receptor type 9 (PTPN9) and receptor-type tyrosine-protein phosphatase F (PTPRF) were repressed. We confirmed that miR-24 could directly target both PTPN9 and PTPRF. Consistent with this, we found that the levels of phosphorylated epidermal growth factor receptor (pEGFR) were higher whereas the levels of PTPN9 and PTPRF were lower in the patients with metastatic breast carcinoma. Ectopic expression of PTPN9 and PTPRF decreased pEGFR levels, cell invasion, migration and tumor metastasis. Furthermore, we found that MMP2, MMP11, pErk, and ADAM15 were upregulated, whereas TIMP2 was downregulated; all of which supported the roles of miR-24 in tumor invasion and metastasis. Our results suggest that miR-24 plays a key role in breast cancer invasion and metastasis. miR-24 could potentially be a target for cancer intervention.
Conceptualizing the Spectrum of the Bereavement Discourse

This article presents the spectrum of the bereavement discourse, namely, how various social groups interpret the loss of their children’s lives or the potential risk to their lives posed by their military service and translate it into public discourse, as a spectrum of attitudes. It is argued that this spectrum ranges from subversive to submissive approaches. Furthermore, within the confines of the declining casualty tolerance, two variables cumulatively determine the actors’ choice of discourse: the level of enforcement of recruitment, ranging from conscription to voluntary recruitment, and the social position of the group to which the agents belong. Given that conscription brings powerful, high-status groups into the ranks who may be unwilling to make sacrifices for war, subversive responses are more likely to occur in conscript militaries than in volunteer forces and vice versa. This article maps this spectrum and hypothesizes about its determinants.
Modulation of Sodium Channel Inactivation Gating by a Novel Lactam: Implications for Seizure Suppression in Chronic Limbic Epilepsy

Epilepsy remains a devastating neurological disorder associated with recurrent, unprovoked, spontaneous epileptic seizures. Current treatments involve seizure suppression using antiepileptic drugs (AEDs); however, many patients remain refractory to current treatments or suffer serious side effects. In view of this continued need for more effective and safer AEDs, we have designed a novel compound, 3-hydroxy-3-(4-methoxyphenyl)-1-methyl-1,3-dihydro-indol-2-one (YWI92), based on a lactam structural class, and evaluated its modulation of human neuronal sodium channel isoform (hNav)1.2 currents and hippocampal neuron action potential firing. Furthermore, we have tested its AED activity using a chronic and acute rat seizure model. In a similar manner to lamotrigine, a clinically used AED, YWI92 exhibited tonic block of hNav1.2 channels and caused a hyperpolarizing shift in the steady-state inactivation curve when using a 30-s inactivating prepulse. YWI92 also delayed the time constants of channel repriming after a 30-s inactivating prepulse and exhibited use-dependent block at 20-Hz stimulation frequency. In membrane excitability experiments, YWI92 inhibited burst firing in CA1 neurons of animals with temporal lobe epilepsy at concentrations that had little effect on CA1 neurons from control animals. These actions on neuronal activity translated into AED activity in the maximal electroshock acute seizure model (ED50 = 22.96 mg/kg), and importantly, in a chronic temporal lobe epilepsy model, in which the mean number of seizures was reduced. Notably, YWI92 exhibited no sedative/ataxic side effects at concentrations up to 500 mg/kg. In summary, greater affinity for inactivated sodium channels, particularly after long depolarizing prepulses, may be important for both anticonvulsant activity and drug tolerability.
Appraising the role of visual threat in speeded detection and classification tasks

This research examines the speeded detection and, separately, classification of photographic images of animals. In the initial experiments each display contained various images of animals and, in the detection task, participants responded whether a display contained only images of birds or also included an oddball target image of a cat or dog. In the classification search task, a target was always present and participants classified this as an image of a cat or a dog. Half of the target images depicted the animal in a non-threatening state and the remaining half images depicted the animal in a threatening state. A complex pattern of effects emerged showing some evidence of more efficient detection of a threatening than non-threatening target. No corresponding pattern emerged in the data for the classification task. Next the tasks were repeated when the stimuli were more carefully matched in terms of general pose and salience of facial features. Now the effects in the detection task were reduced but more consistent than before. Threatening targets were more readily detected than non-threatening targets. In addition, non-threatening targets were more readily classified than threatening targets. The nature of these effects appears to reflect decisional/response mechanisms and not search processes. The performance benefit for the non-threatening images was replicated in a final classification task in which, on each trial, only a single peripheral image was presented. The results demonstrate that a number of different affective and perceptual factors can influence performance in speeded search tasks and these may well be confounded with the variation in threat content of the experimental stimuli. The evidence for the automatic detection of visual threat remains illusive.
Solving Constraint Satisfaction Problems by ACO with Cunning Ants

To solve large-scale constraint satisfaction problems, CSPs, ant colony optimization, ACO, based meta-heuristics has been used. However, the naive ACO based method is sometimes inefficient because the method may require much search time due to ant's reconstructing candidate solutions. In this paper, we describe an ant colony optimization based meta-heuristics with cunning ants in which artificial ants construct a candidate solution by partially using building blocks, or useful partial solutions, of the candidate solution constructed at the previous search generation in order to solve CSP instances. We also propose some methods for using building blocks and conduct some experimental simulations, demonstrating that how effective our method can be by variation of using the building blocks.
Complexity, predictability and promiscuity in human sexual preferences

Reproductive success (fitness) is the currency for species evolution, and therefore, the establishment of sexual relationships is one of the most fundamental interactions underlying life on Earth. Sexual selection theory aims to explain the strength and implications of sexual bonds as a result of traits that evolve to influence sexual encounters and thus, reproductive success. Humans offer a valuable ‘model’ to understand the nature of sexual behaviour, especially because their preferences can be directly communicated by individual participants, in contrast with non-human animals in which preferences are inferred from behavioural observations. The high social complexity of humans has led to multiple approaches to understand individuals’ attitudes and behaviours within an eco-evolutionary context, particularly with regards to investigating how ‘attractiveness’ traits influence sexual relationships, and how the expression of these traits matches sexual outcomes (i.e., as a proxy for mating success). Although humans traditionally fall between a polygyny and serial monogamy mating system, it remains poorly known how promiscuity is associated with a ubiquitous factor underlying human social/sexual dynamics: ‘love’. This research investigated how promiscuity (measured as numbers of self-reported sexual partners and as the desire to be promiscuous) and simultaneous love (individuals declaring whether they can ‘fall in love’ with more than one person simultaneously) are affected by a number of different traits (gender, age, self-assessed attractiveness, sexual orientation) and interpreted under predictions of sexual selection theory. Using a newly generated dataset, it was quantified how self-assessed attractiveness traits influence the expression of promiscuous desires across participants. The majority (84.5%) of participants displayed a desire for promiscuity. Gender and sexual orientation are the main variables in which there is a relationship in participant’s desires for promiscuity and simultaneous love. Notably, this research revealed that more than half of the individuals in the sample (57.1%) expressed the possibility to love more than one person simultaneously. This finding goes against fundamental norms underlying monogamous sexual relationships in most human societies. Collectively, this thesis provides novel data to further discuss promiscuity in humans.
The Riemann problem for the shallow water equations with discontinuous topography

We construct the solution of the Riemann problem for the shallow water equations with discontinuous topography. The system under consideration is non-strictly hyperbolic and does not admit a fully conservative form, and we establish the existence of two-parameter wave sets, rather than wave curves. The selection of admissible waves is particularly challenging. Our construction is fully explicit, and leads to formulas that can be implemented numerically for the approximation of the general initial-value problem.
A Hybrid Particle Swarm—Gradient Algorithm for Global Structural Optimization

Abstract: The particle swarm optimization (PSO) method is an instance of a successful application of the philosophy of bounded rationality and decentralized decision making for solving global optimization problems. A number of advantages with respect to other evolutionary algorithms are attributed to PSO making it a prospective candidate for optimum structural design. The PSO‐based algorithm is robust and well suited to handle nonlinear, nonconvex design spaces with discontinuities, exhibiting fast convergence characteristics. Furthermore, hybrid algorithms can exploit the advantages of the PSO and gradient methods. This article presents in detail the basic concepts and implementation of an enhanced PSO algorithm combined with a gradient‐based quasi‐Newton sequential quadratic programming (SQP) method for handling structural optimization problems. The proposed PSO is shown to explore the design space thoroughly and to detect the neighborhood of the global optimum. Then the mathematical optimizer, starting from the best estimate of the PSO and using gradient information, accelerates convergence toward the global optimum. A nonlinear weight update rule for PSO and a simple, yet effective, constraint handling technique for structural optimization are also proposed. The performance, the functionality, and the effect of different setting parameters are studied. The effectiveness of the approach is illustrated in some benchmark structural optimization problems. The numerical results confirm the ability of the proposed methodology to find better optimal solutions for structural optimization problems than other optimization algorithms.
Prognostic implications of physiologic and radiographic changes in idiopathic interstitial pneumonia.

Idiopathic interstitial pneumonias are a diverse group of lung diseases with varied prognoses. We hypothesized that changes in physiologic and radiographic parameters would predict survival. We retrospectively examined 80 patients with usual interstitial pneumonia and 29 patients with nonspecific interstitial pneumonia. Baseline characteristics were examined together with 6-month change in forced vital capacity, diffusing capacity for carbon monoxide, and ground glass infiltrate and fibrosis on high resolution computed tomography. Patients with usual interstitial pneumonia were more likely to have a statistically significant or marginally significant decline in lung volume, diffusing capacity for carbon monoxide, and an increase in ground glass infiltrates (p < or = 0.08) compared with patients with nonspecific interstitial pneumonia. For patients with usual interstitial pneumonia, change in forced vital capacity was the best physiologic predictor of mortality (p = 0.05). In a multivariate Cox proportional hazards model controlling for histopathologic diagnosis, gender, smoking history, baseline forced vital capacity, and 6-month change in forced vital capacity, a decrease in forced vital capacity remained an independent risk factor for mortality (decrease > 10%; hazard ratio 2.47; 95% confidence interval 1.29, 4.73; p = 0.006). We conclude that a 6-month change in forced vital capacity gives additional prognostic information to baseline features for patients with idiopathic interstitial pneumonia.
USNCTAM perspectives on mechanics in medicine

Over decades, the theoretical and applied mechanics community has developed sophisticated approaches for analysing the behaviour of complex engineering systems. Most of these approaches have targeted systems in the transportation, materials, defence and energy industries. Applying and further developing engineering approaches for understanding, predicting and modulating the response of complicated biomedical processes not only holds great promise in meeting societal needs, but also poses serious challenges. This report, prepared for the US National Committee on Theoretical and Applied Mechanics, aims to identify the most pressing challenges in biological sciences and medicine that can be tackled within the broad field of mechanics. This echoes and complements a number of national and international initiatives aiming at fostering interdisciplinary biomedical research. This report also comments on cultural/educational challenges. Specifically, this report focuses on three major thrusts in which we believe mechanics has and will continue to have a substantial impact. (i) Rationally engineering injectable nano/microdevices for imaging and therapy of disease. Within this context, we discuss nanoparticle carrier design, vascular transport and adhesion, endocytosis and tumour growth in response to therapy, as well as uncertainty quantification techniques to better connect models and experiments. (ii) Design of biomedical devices, including point-of-care diagnostic systems, model organ and multi-organ microdevices, and pulsatile ventricular assistant devices. (iii) Mechanics of cellular processes, including mechanosensing and mechanotransduction, improved characterization of cellular constitutive behaviour, and microfluidic systems for single-cell studies.
Managerial Compensation and Monitoring in a Non-Profit Organization : Evidence from the Irish Loan Funds *

Using unique data on the Irish loan funds, a nineteenth-century system of quasi-banks, we show that higher levels of uncontrolled capital, where there is no residual claimant, lead to higher wages. The loan funds relied on deposits, as well as donations and accumulated profits, to finance their lending. We examine the effect of different levels of deposits and capital on managerial salaries and expenses. Higher net income (before non-interest expenses) is associated with higher non-interest expenses. More surprisingly, lower deposit to capital ratios and smaller numbers of depositors lead to higher expenses even after controlling for net income. Hypotheses for understanding this finding suggest that depositors can play an important role in microfinance such as that currently found in development contexts. More generally, this provides some insight into the determination of compensation in non-profit organizations.