Miracle-dz/UniFAR-FTUs huggingface dataset:
A cognitive-behavioural pedometer-based group intervention on physical activity and sedentary behaviour in individuals with type 2 diabetes

The purpose of this study was to investigate the benefits of a pedometer and a cognitive-behavioural group intervention for promoting physical activity (PA) in type 2 diabetes patients. We recruited 41 participants and randomized them into an intervention group (IG) (n = 20) and a control group (CG) (n = 21). The intervention consisted of five sessions within 12 weeks, a booster session after 22 weeks and a pedometer. Primary outcome was PA assessed by accelerometer (minutes per day) and pedometer (steps per day). Secondary outcomes were weight, body mass index, blood pressure, haemoglobin A1c and total cholesterol. After 12 weeks, the IG increased with more than 2000 steps day−1 compared with the CG, whereas sedentary behaviour decreased more than 1 hour day−1 in the IG and showed no change in the CG. There was no intervention effect on the accelerometer-based PA nor on health measurements. After 1 year, the increase in steps per day remained significant in the IG, but sedentary activity increased again to baseline levels. This pilot study showed that the combination of a 12-week cognitive-behavioura intervention and a pedometer has a significant short-term impact on daily steps and sedentary behaviour but that the effects on total PA and long-term effects were limited.
Relations Among Emergent Literacy Skills, Behavior Problems, and Social Competence in Preschool Children From Low- and Middle-Income Backgrounds

Research has indicated a substantial overlap between reading disability (RD) and attention-deficit/hyperactivity disorder (ADHD). However, few studies concerning this overlap have been conducted with preschool children. This study examined the overlap between behaviors associated with ADHD and emergent literacy skills in preschool children. One group of 44 children (mean age = 48 months, SD = 11.3) was from middle-income families, and one group of 41 children (mean age = 53 months, SD = 8.1) attended Head Start. Results demonstrated that attention problems were substantially, consistently, and uniquely associated with emergent literacy skills in both groups; however, the effect was strongest for the middle-income group. These findings indicate that the association between reading skills and behaviors associated with ADHD is present in preschool children and that emergent literacy skills may mediate the link between ADHD and RD found in older children.
Outcome Prediction of Cognitive Behaviour Therapy for Panic Disorder: Initial Symptom Severity is Predictive for Treatment Outcome, Comorbid Anxiety or Depressive Disorder, Cluster C Personality Disorders and Initial Motivation Are Not

Five variables were investigated with regard to their possible predictive value for cognitive behavioural treatment (CBT) outcome in a large sample of panic disorder (PD) patients. The variables were initial symptom severity, comorbid anxiety or depressive disorders, comorbid cluster C personality disorders, and initial motivation for treatment. A total number of 161 PD patients received a standardized CBT of 15 sessions. Assessments of predictive variables took place prior to treatment. Outcome measures were assessed at pre- and posttreatment. The patients had significantly improved after the treatment. None of the variables, separately or together, affected CBT outcome, save initial severity of panic disorder symptoms, which was positively associated with posttreatment symptom severity. Since research efforts failed to produce consistent predictors for CBT treatment outcome in panic disorder thus far, the usefulness of future outcome prediction research in panic disorder by pre-treatment demographic, disorder-related, psychological, or socio-psychological variables is put into question.
Inhibition of the Insulin-Like Growth Factor I Receptor by Epigallocatechin Gallate Blocks Proliferation and Induces the Death of Ewing Tumor Cells

The insulin-like growth factor I receptor (IGFIR) has emerged as a key therapeutic target in many human malignancies, including childhood cancers such as Ewing family tumors (EFT). In this study, we show that IGFIR is constitutively activated in EFTs and that the major catechin derivative found in green tea, (−)-epigallocatechin gallate (EGCG), can inhibit cell proliferation and survival of EFT cells through the inhibition of IGFIR activity. Treatment of EFT cell lines with EGCG blocked the autophosphorylation of IGFIR tyrosine residues and inhibited its downstream pathways including phosphoinositide 3-kinase-Akt, Ras-Erk, and Jak-Stat cascades. EGCG treatment was associated with dose- and time-dependent inhibition of cellular proliferation, viability, and anchorage-independent growth, as well as with the induction of cell cycle arrest and apoptosis. Apoptosis in EFT cells by EGCG correlated with altered expression of Bcl-2 family proteins, including increased expression of proapoptotic Bax and decreased expression of prosurvival Bcl2, Bcl-XL, and Mcl-1 proteins. Our results provide further evidence that IGFIR is an attractive therapeutic target in EFTs and that EGCG is an effective inhibitor of this receptor tyrosine kinase. EGCG may be a useful agent for targeting IGFIR, either alone or in combination, with other potentially more toxic IGFIR inhibitors for the management of EFTs. Mol Cancer Ther; 9(5); 1396–407. ©2010 AACR.
Brønsted basicity of the air–water interface

Differences in the extent of protonation of functional groups lying on either side of water–hydrophobe interfaces are deemed essential to enzymatic catalysis, molecular recognition, bioenergetic transduction, and atmospheric aerosol–gas exchanges. The sign and range of such differences, however, remain conjectural. Herein we report experiments showing that gaseous carboxylic acids RCOOH(g) begin to deprotonate on the surface of water significantly more acidic than that supporting the dissociation of dissolved acids RCOOH(aq). Thermodynamic analysis indicates that > 6 H2O molecules must participate in the deprotonation of RCOOH(g) on water, but quantum mechanical calculations on a model air–water interface predict that such event is hindered by a significant kinetic barrier unless OH− ions are present therein. Thus, by detecting RCOO− we demonstrate the presence of OH− on the aerial side of on pH > 2 water exposed to RCOOH(g). Furthermore, because in similar experiments the base (Me)3N(g) is protonated only on pH < 4 water, we infer that the outer surface of water is Brønsted neutral at pH ∼3 (rather than at pH 7 as bulk water), a value that matches the isoelectric point of bubbles and oil droplets in independent electrophoretic experiments. The OH− densities sensed by RCOOH(g) on the aerial surface of water, however, are considerably smaller than those at the (>1 nm) deeper shear planes probed in electrophoresis, thereby implying the existence of OH− gradients in the interfacial region. This fact could account for the weak OH− signals detected by surface-specific spectroscopies.
In-vitro experimental analysis and numerical study of temperature in bone drilling.

BACKGROUND Bone drilling is a common practice of surgical treatments in orthopaedics and traumatology. Penetration of a high-speed drill into bone tissue is accompanied by generation of a significant amount of heat. Cooling of the drilling region is necessary to avoid potential risk of thermal damage to bone. OBJECTIVE The purpose of this study was to measure and predict bone temperature by conducting experiments and numerical simulations using cooling by means of irrigation at two different temperatures. METHODS A series of experiments and numerical studies were performed to investigate the effect of cooling conditions on the rise in bone temperature in drilling. The temperature increase in bone was assessed for different drilling speeds and feed rates in the presence irrigation at 5 °C and 25 °C. RESULTS Bone temperature was found to be strongly affected by the drilling parameters and cooling conditions. Irrigation with water at 5 °C kept bone temperature well below the thermal threshold level. CONCLUSION This study strongly recommends the use of irrigation at lower temperature for safe surgical incision.
Highly Purified versus Filtered Crude Collagenase: Comparable Human Islet Isolation Outcomes

This study was designed to retrospectively compare the impact of crude Sigma V collagenase (Sigma V, n = 52) with high-purified Serva NB1 collagenase (Serva NB1, n = 42) on human islet isolation outcomes. A three-step filtration was applied to the crude Sigma V to remove endotoxin contamination and impurities; in addition, this process was used as a lot prescreening tool. Isolation outcomes were determined by digestion efficacy, islet yields, purity, viability, glucose-stimulated insulin release, and endotoxin content. The digestion efficacy between Sigma V and Serva NB1 was statistically significant (Sigma V: 64.71% vs. Serva NB1: 69.71%, p = 0.0014). However, the islet yields were similar (Sigma V: 23422.58 vs. Serva NB1: 271097 IEq, p = 0.23) between groups. There was no significant purity difference observed in fractions with purities greater than 75%. Viability (Sigma V: 93.3% vs. Serva NB1: 94.8%, p = 0.061) and stimulation indexes (Sigma V: 3.41 vs. Serva NB1: 2.74, p = 0.187) were also similar between the two groups. The impact of cold ischemia and age on the isolation outcome in the Sigma V group was comparable to the Serva NB1 group. The endotoxin content of the final products in the filtered Sigma V group was significantly less than that in the high-purified Serva NB1 group (0.022 vs. 0.052 EU/ml, p = 0.003). Additionally, in the Sigma V group there was minimal lot to lot variation and no significant loss of enzymatic activity after filtration. These findings indicate that the use of Sigma V or other crude enzyme blends for research pancreata is warranted to reduce isolation costs and increase the amount of islets available for critical islet research. These findings also validate the need for a systematic enzyme analysis to resolve these inconsistencies in overall enzyme quality once and for all.
The Effect of Blended Learning on the Persistence of Academic Performance for Computer Education

Nowadays new learning processes are being designed where online education is reinforced and used along with face to face education. This co-use that was established to eliminate various limitations is called Blended Learning (BL). Blending could be considered as building a new process by combining the positive aspects of online and face to face processes levelly. In this study, we shared the research to determine the effect of the BL process on the persistence of the learners' academic performance. The research was conducted by the participation of 63 university students in Turkey to a 10-weeks implementation of a BL process designed by the researchers. The research showed that the effect of the BL process on the persistence of the academic performance is more pronounced than that of face to face learning process. Keywords: Blended learning, academic performance, persistence in education
The Perils and Possibilities of Assessment

Figure 1: The Functions of Assessment Along this assessment continuum, which ranges from informal and instantaneous response to the formalised rigours of reports, tests and examinations, teachers find themselves playing several different roles, assessing in different ways and for various purposes. Teachers do far more than simply reject and select. Nor do they merely examine and report. Fundamental to educational transactions is a process of interaction and comparison.
Stochastic Second-Order Optimization via von Neumann Series

A stochastic iterative algorithm approximating second-order information using von Neumann series is discussed. We present convergence guarantees for strongly-convex and smooth functions. Our analysis is much simpler in contrast to a similar algorithm and its analysis, LISSA. The algorithm is primarily suitable for training large scale linear models, where the number of data points is very large. Two novel analyses, one showing space independent linear convergence, and one showing conditional quadratic convergence are discussed. In numerical experiments, the behavior of the error is similar to the second-order algorithm L-BFGS, and improves the performance of LISSA for quadratic objective function.
What Was, What is, and What May Be in Op/Ob

This article presents a personalized view of the history, development, and current shape of the related fields of industrial–organizational (I/O) psychology and organizational behavior (OB) by two authors who have personally experienced many of the events and changes that have occurred in these fields over the past 50 or so years. Particular attention is given to the interconnections and differences between I/O psychology and OB and to the implications of those differences and overlaps for research and professional practice. The article concludes with some thoughts about areas of potential advances that could be made in the future and a discussion of some of the challenges to be faced in making those kinds of progress.
What lies beneath teacher beliefs? A study on metaphoric perceptions

The purpose of this qualitative study is to examine the metaphors a foreign language teacher used to describe her teaching experience and the role she adopted. The study tries to follow the conceptualizations of an experienced EFL teacher in regard to her teaching experience and the role she adopted. The data for the present study were collected by means of metaphor elicitation sheet, interview, and diary. The data were collected every month over a period of 24 months. The results revealed that during the first period of data collection (12 months), the participant teacher developed 10 different metaphors with regard to the concept of “teacher”. The number of new metaphors developed in the second period of data collection (the second 12 months) was 7, most of which implied the democratic teacher. Even though the same metaphor was used at different times, the rationale behind using the same metaphor always yielded differences.
DNA-mediated Folding and Assembly of MyoD-E47 Heterodimers*

Basic region helix-loop-helix (bHLH) transcription factors regulate key steps in early development by binding to regulatory DNA sites as heterodimers consisting of a tissue-specific factor and a widely expressed factor. We have examined the folding, dimerization, and DNA binding properties of the muscle-specific bHLH protein MyoD and its partner E47, to understand why these proteins preferentially associate in heterodimeric complexes with DNA. In the absence of DNA, the E47 bHLH domain forms a very stable homodimer, whereas MyoD is unfolded and monomeric. Fluorescence quenching experiments show that MyoD does not dimerize with E47 under dilute conditions in the absence of DNA. Residues in and around the loop of the E47 bHLH domain contribute to its markedly greater stability. An altered MyoD bHLH substituted with the loop segment from E47 folds in the absence of DNA, and it readily dimerizes with E47. In the presence of a specific DNA binding site, MyoD and E47 both form homodimeric complexes with DNA that have similar dissociation constants, despite the very different stabilities of these protein dimers off DNA. A 1:1 mixture of these bHLH domains forms almost exclusively heterodimeric complexes on DNA. Assembly of these bHLH-DNA complexes is apparently governed by the strength of each subunit’s interaction with the DNA and not by the strength of protein-protein interactions at the dimer interface. These findings suggest that preferential association of MyoD with E47 in DNA complexes results from more favorable DNA contacts made by one or both subunits of the heterodimer in comparison with either homodimeric complex.
Resource Allocation and Cluster Formation for Imperfect NOMA in DL/UL Decoupled HetNets

Being capable of serving multiple users with the same radio resource, non-orthogonal multiple access (NOMA) can provide desirable performance enhancements in a fair and spectral efficient manner. In this paper, we investigate the resource allocation (RA) and cluster formation (CF) aspects of NOMA for downlink (DL) uplink (UL) decoupled (DUDe) heterogeneous networks (HetNets). A non-ideal NOMA scheme is considered with power disparity and sensitivity constraints (PDSCs), delay tolerance, and residual interference after cancellation. Taking the PDSCs into account, we analytically show that using the DL decoding order limits UL-NOMA performance by that of OMA, while employing an inverse order result in a performance gain that is mainly determined by the channel gain disparity of users. Thereafter, a generic CF method is proposed for any type of user graph, which iteratively forms clusters using Blossom algorithm. Finally, highly non-convex RA problem is converted into a convex form by employing geometric programming (GP) where power and bandwidth are optimized to maximize network sumrate and max-min fairness objectives.
Glucocorticoid-induced lymphocytolysis is not mediated by an induced endonuclease.

The mechanism of glucocorticoid-induced internucleosomal DNA cleavage and cytolysis of lymphatic cells is not known. Recent data (Compton, M.M., and Cidlowski, J.A. (1987) J. Biol. Chem. 262, 8288-8292) suggested that in vivo treatment of rat thymocytes with glucocorticoids induces a nucleolytic "lysis gene" product(s) responsible for lymphocytolysis. In this paper, the possibility that lymphocytolysis may result from glucocorticoid-induced nuclease(s) was examined. Using the rat thymocytes as a model system, we have shown by electrophoretic, enzymatic, and amino acid sequence analysis that the putative glucocorticoid-induced nucleases identified recently by Compton and Cidlowski are in fact H1, H1(0), and core histones, and their gross appearance is not the result of new histone protein synthesis, but a result of the release of histone-containing nucleosomes during chromatin breakdown. Evidence presented here shows that the putative induced nuclease activity is an artifact of the assay system employed. Because our data do not support induction of a glucocorticoid-induced nuclease(s), we examined the possibility that DNA cleavage might be induced by activation of a constitutive endogenous endonuclease. We have shown that it is possible to produce characteristic internucleosomal DNA cleavage of rat thymocytes, merely by incubating intact nuclei from untreated adrenalectomized rat thymocytes with Ca2+ and Mg2+ for a short period of time. However, in glucocorticoid-sensitive human CEM-C7 lymphocytes activation of internucleosomal DNA cleavage was independent of calcium uptake. We conclude that glucocorticoid induction of internucleosomal DNA fragmentation does not necessarily require expression of a new nuclease(s), but is the result of the activation of a constitutive endogenous endonuclease(s). Also, our data suggest that the mechanism which controls activation of internucleosomal DNA cleavage in rat thymocytes differs from that which operates in CEM-C7 lymphocytes.
Clostridium difficile Infection in the Hospitalized Pediatric Population: Increasing Trend in Disease Incidence

To determine whether the incidence of Clostridium difficile infection continues to increase in hospitalized pediatric patients, we evaluated data from a United States national inpatient database. For the period of 2003 to 2009, we found an increasing trend in the incidence of C. difficile infection. These data suggest greater effort be given to prevent and treat this infection in children.
Comparison of refractive development and retinal dopamine in OFF pathway mutant and C57BL/6J wild-type mice

Purpose Proper visual transmission depends on the retinal ON and OFF pathways. We used Vsx1−/− mice with a retinal OFF visual pathway defect to determine the role of OFF pathway signaling in refractive development (RD) of the eye. Methods Refractive development was measured every 2 weeks in Vsx1−/−, Vsx1+/+ (both on 129S1/Sv background), and commonly used C57BL/6J mice from 4 to 12 weeks of age. Form deprivation (FD) was induced monocularly from 4 weeks of age using head-mounted diffuser goggles. Refractive state, corneal curvature, and ocular biometry were obtained weekly using photorefraction, keratometry, and 1310 nm spectral-domain optical coherence tomography. Retinal dopamine and its metabolite, 3,4-dihydroxyphenylacetate (DOPAC), were measured using high-performance liquid chromatography (HPLC). Results During normal development, the Vsx1−/− and Vsx1+/+ mice showed similar myopic refractions at younger ages (4 weeks, Vsx1−/−: −5.28±0.75 diopter (D); WT: −4.73±0.98 D) and became significantly hyperopic by 12 weeks of age (Vsx1−/−: 3.28±0.82 D; WT: 5.33±0.81 D). However, the C57BL/6J mice were relatively hyperopic at younger ages (mean refraction at 4 weeks, 3.40±0.43 D), and developed more hyperopic refractions until about 7 weeks of age (8.07±0.55 D) before stabilizing. Eight weeks of FD did not induce a myopic shift in the 129S1/Sv animals (0.16±0.85 D), as opposed to a significant shift of −4.29±0.42 D in the C57BL/6J mice. At 4 weeks of visual development, dopamine turnover (the DOPAC/dopamine ratio) was significantly greater in the 129S1/Sv mice compared to the C57BL/6J mice. FD did not alter the levels of dopamine between the goggled and opposite eyes for any genotype or strain. Conclusions OFF pathway signaling may not be critically important for normal refractive development in mice. Elevated retinal dopamine turnover in early refractive development may prevent FD myopia in 129S1/Sv mice compared to C57BL/6J mice.
Maternal differential treatment of siblings and children's behavioral problems: A longitudinal study

Abstract Researchers have examined links between maternal differential treatment of siblings and children's adjustment; however, little is known about the longitudinal nature of these associations. The goal of this study was to examine the relationship between maternal differential treatment of the siblings, direct parenting of older siblings, and older siblings' behavior problems across middle childhood. Eighty-two families were interviewed twice in their homes when the siblings averaged 4.7 and 7.7 years of age and, again when they averaged 7.9 and 10.5 years of age. Mothers completed questionnaires about parenting and older siblings' adjustment during the summer after the older siblings' 7th and 11th birthdays. Teachers completed questionnaires about the older siblings' adjustment and returned them through the mail. There was significant stability in the mothers' reports of differential treatment and significant associations between mothers' reports of maternal differential discipline and differential attention and mothers' and teachers' reports of older siblings' externalizing problems across time. Direct parenting measures were not correlated with differential treatment or older siblings' behavior problems across time.
Disclosing Celebrity Endorsement in a Television Program to Mitigate Persuasion: How Disclosure Type and Celebrity Credibility Interact

This experiment (N = 165) examined the effects of two aspects of in-program celebrity endorsement on brand attitudes and product claim acceptance: credibility of the celebrity and the effects of disclosure types. Although there is an increasing call for endorsement disclosures, the effects of these disclosures remained unstudied. This study, conducted in The Netherlands, showed that disclosure of the persuasive intent of in-program celebrity endorsements only resulted in reduced acceptance of product claims among viewers who did not perceive the celebrity in the endorsement as credible. This study has important implications for legislators.