Miracle-dz/UniFAR-FTUs huggingface dataset:
Multicommodity flow and circuit switching

Given a set of request pairs in a network, the problem of routing virtual circuits with low congestion is to connect each pair by a path so that few paths use the same link in the network. We build on an earlier multicommodity flow based approach of Leighton and Rao (1996) to show that short flow paths lead to path selections with low congestion. This shows that such good path selections exist for constant-degree expanders with strong expansion, generalizing a result of (Broder et al., 1994). We also show, for infinitely many n, n-vertex undirected graphs G/sub n/ along with a set T of connection requests, such that: T is fractionally realizable using flow-paths that impose a (fractional) congestion of at most 1; but any rounding of such a flow to the given set of flow-paths, leads to a congestion of /spl Omega/(log n/log log n). This is progress on a long-standing open problem.
Trends in management of myofacial pain

We systematically reviewed the myofascial pain publications in the literature. The aim of this article is to review the methods of management and their outcome and factors associated with prognosis. The topics of interest in the diagnostic process are myofascial trigger points electromyography, jaw tracking, joint sound recorder, sonography, and vibratography, exclusion of other orofacial pain and temporomandibular disorders. Management modalities are occlusal therapy, physiotherapy, multidimensional rehabilitation antinociceptive therapy, anti-inflammatory and analgesics, muscle relaxants, stretch, and spray technique, transcutaneous electric nerve stimulation, and in severe cases botulinum toxin may be tried. The disease required interdisciplinary interaction in terms of occlusal therapy, antinociceptive therapy and physiotherapy because management of the disease may be influenced by the specialist primarily treating the patients.
Free Fibula Osteocutaneous Flap With Soleus Muscle as a Chimeric Flap for Reconstructing Mandibular Segmental Defect After Oral Cancer Ablation

In some cases, the fibula osteocutaneous flap may not provide sufficient soft tissue for obliterating dead space after tumor ablation. This report describes a modified fibula osteocutaneous flap using a portion of soleus muscle to reduce postoperative complications. This study analyzed 20 patients who underwent ablative oral cancer surgery with mandibular segmental defect between September 2005 and June 2007. Of total, 17 cases were mandible complex defects and 3 were composite defects. Of total, 18 were men and 2 were women, respectively. Age range was 30 to74 years, and mean age was 53 years. The procedure entailed harvest of chimeric fibula flap with skin paddle and bone segment composed of a sheet of soleus muscle (7 × 4 to 12 × 5 cm in size) originating from the perforator branch of the peroneal artery. The soleus muscle was used to obliterate the dead space of the mouth floor and cheek-neck area. All flaps survived except 1 failure due to venous insufficiency. The submandibular and chin area exhibited mild swelling at the submandibular area early postoperatively. Patients had achieved satisfactory contour without donor site morbidity at a mean 12-months of follow-up. Complications included 2 flaps requiring reoperation due to the flap pedicle compromised. One flap was successfully salvaged but the other failed. Two cases of orocutaneous fistula-induced infection recovered after conservative treatment. Donor site assessment revealed a satisfactory outcome without major donor site morbidity. This refinement in mandibular reconstructive surgery substantially reduces postoperative complications.
A Synchronized 35 GHz Divide-by-5 TSPC Flip-Flop Clock Divider in 22 nm FDSOI

This work proposes an integrated divide-by-five clock divider based on a true single-phase-clock (TSPC) ring buffer. Fabricated in a 22 nm fully-depleted silicon on insulator (FDSOI) technology, the circuit can synchronously divide input frequencies up to 35 GHz, where it exhibits a power consumption of 1.35 mW. The divider core consumes an area of $12.1 \times 2.8 \mathrm{~m}^{2}$ and is integrated into a multi-circuit break out chip of $600 \times 530 \mathrm{~mm}^{2}$. It is designed to extend high-speed mm-wave circuits by a digital block operating synchronously at one-fifth of the clock rate.
Hepatitis B virus reactivation associated with anti‐neoplastic therapy

Reactivation of hepatitis B virus (HBV) infection is a known complication during and after anti‐cancer therapy. This condition can affect two patient populations: it is most commonly seen in patients who are seropositive for hepatitis B surface antigen (HBsAg), but it is also being increasingly reported among patients who are HBsAg‐negative but who have prior infection, as evident by seropositive status for antibody to hepatitis B core antigen (anti‐HBc), irrespective of their anti‐HBs (antibody to HBsAg) status. The clinical course can vary from asymptomatic hepatitis to fulminant hepatic failure that can be potentially fatal. With the increasing use of biological agents in addition to potent cytotoxic chemotherapy in the armamentarium of anti‐cancer treatments, reactivation of hepatitis B has become a common clinical situation that is faced by both oncologists and hepatologists especially in HBV endemic areas. In this review, we discuss the clinical course of reactivation in the two HBV‐infected sub‐populations, and the role of anti‐virals in the prevention and management of HBV reactivation in association with cytotoxic chemotherapy and biological therapies.
Atmospheric Plasma Spraying of Single Phase Lanthanum Zirconate Thermal Barrier Coatings with Optimized Porosity

The shortcomings at elevated operation temperatures of the standard material yttria-stabilized zirconia (YSZ) for thermal barrier coatings (TBCs) have initiated many research activities seeking alternatives. One candidate is the pyrochlore lanthanum zirconate La2Zr2O7 (LZ), which is phase-stable to its melting point. At the same time, it shows a lower thermal conductivity and a lower sintering tendency when compared to YSZ. Because of its low thermal expansion coefficient and poor toughness, it is applied in combination with YSZ in double layer TBC systems. It is the current state of knowledge that LZ is prone to lanthanum depletion if processed by plasma spraying. The process conditions have to be selected carefully to avoid this. Furthermore, the amount and morphology of the coating porosity is essential for a good thermo-mechanical performance. In this work, the development and testing of LZ/YSZ double layer TBC systems is described. Initially, suitable basic parameters (torch, plasma gas composition, and power) were tested with respect to coating stoichiometry. Then, microstructures were optimized by adjusting feed rate, spray distance, and by selecting a more appropriate feedstock. Powder particles and coatings were characterized by digital image analysis.
Buprenorphine and Naloxone Compared With Methadone Treatment in Pregnancy

OBJECTIVE: To compare neonatal abstinence syndrome prevalence and characteristics among neonates born to women prescribed buprenorphine and naloxone compared with methadone during pregnancy. METHODS: Retrospective cohort analysis of mother–neonate dyads treated with either buprenorphine and naloxone or methadone during pregnancy. Primary neonatal outcomes included diagnosis of neonatal abstinence syndrome, neonatal abstinence syndrome peak scores, total amount of morphine used to treat neonatal abstinence syndrome (mg), and duration of treatment for neonatal abstinence syndrome (days). Secondary outcomes included head circumference, birth weight, length, preterm birth, neonatal intensive care unit admission, Apgar scores, and overall length of hospitalization. RESULTS: From January 1, 2011, to November 30, 2013, we identified 62 mother–neonate dyads, 31 treated with methadone and 31 treated with buprenorphine and naloxone. Sixteen neonates (51.6%) in the methadone group were diagnosed with neonatal abstinence syndrome compared with eight (25.1%) in the buprenorphine and naloxone group (adjusted odds ratio 2.55, 95% confidence interval [CI] 1.31–4.98, P=.01). The buprenorphine and naloxone-exposed neonates had lower peak neonatal abstinence syndrome scores (9.0±4.4 compared with 10.7±3.7, multivariate-adjusted mean difference=−2.77, 95% CI −4.99 to −0.56, P=.02) and shorter overall hospitalization (5.6±5.0 compared with 9.8±7.4 days, multivariate-adjusted mean difference=−3.90, 95% CI, −7.13 to −0.67, P=.02). We found no other differences in primary or secondary outcomes. CONCLUSION: In a cohort of pregnant patients treated with either methadone or buprenorphine and naloxone in pregnancy, newborns exposed to maternal buprenorphine and naloxone had less frequent neonatal abstinence syndrome. Additionally, neonates exposed to buprenorphine and naloxone had shorter overall hospitalization lengths. LEVEL OF EVIDENCE: II
B cell activating factor (BAFF) in the natural history of chronic hepatitis C virus liver disease and mixed cryoglobulinaemia

B cell activating factor (BAFF) plays a crucial role in the process of development, maturation and activation of B lymphocytes. Chronic hepatitis C virus (HCV) infection is characterized by multiple B cell disorders. It is a major cause of type II mixed cryoglobulinaemia (MC). We measured serum BAFF levels in several clinical situations to elucidate the potential role of BAFF in chronic HCV infection. We used a commercially available solid phase enzyme‐linked immunosorbent assay. We estimated serum BAFF in stored sera from uninfected controls (n = 8), patients with chronic hepatitis B virus infection HBV (n = 5) and chronic HCV infection with (n = 16) and without mixed cryoglobulinaemia (n = 14). In two patients with HCV and MC we correlated BAFF with HCV RNA after pegylated interferon (peg‐I). We correlated serum BAFF levels at baseline and at 12 weeks with treatment response: sustained virological response SVR (n = 5), non‐responders (n = 6) and relapsers (n = 2). Finally, we estimated BAFF levels after complete depletion of B cells with rituximab in patients with chronic HCV with MC (n = 3). Serum levels of BAFF were increased in chronic HCV with MC, but not in chronic HBV infection, suggesting an association between BAFF and cryoglobulinaemia. Peg‐I increased BAFF levels in serum and this paralleled HCV RNA very closely. Serum BAFF levels at week 12 of therapy with peg‐I and R were significantly higher in responders than non‐responders. Finally, B cell depletion was associated with markedly increased levels of BAFF.
A theory for the spinup of tropical depressions

Recent advances in our understanding of the physics of precipitation over tropical oceans is married with vorticity dynamics to produce a simple theory for the development or non‐development of tropical depressions. This early phase of tropical cyclogenesis is perhaps the least understood part of the whole process. The theory predicts a finite amplitude threshold for intensification, with weaker disturbances decaying. Furthermore, only disturbances with radii larger than a critical value develop. Rough estimates of this critical radius place it near 1600 km, though better estimates of various parameters could change this value significantly. Copyright © 2007 Royal Meteorological Society
Genomic islands of divergence linked to ecotypic variation in sockeye salmon

Regions of the genome displaying elevated differentiation (genomic islands of divergence) are thought to play an important role in local adaptation, especially in populations experiencing high gene flow. However, the characteristics of these islands as well as the functional significance of genes located within them remain largely unknown. Here, we used data from thousands of SNPs aligned to a linkage map to investigate genomic islands of divergence in three ecotypes of sockeye salmon (Oncorhynchus nerka) from a single drainage in southwestern Alaska. We found ten islands displaying high differentiation among ecotypes. Conversely, neutral structure observed throughout the rest of the genome was low and not partitioned by ecotype. One island on linkage group So13 was particularly large and contained six SNPs with FST > 0.14 (average FST of neutral SNPs = 0.01). Functional annotation revealed that the peak of this island contained a nonsynonymous mutation in a gene involved in growth in other species (TULP4). The islands that we discovered were relatively small (80–402 Kb), loci found in islands did not show reduced levels of diversity, and loci in islands displayed slightly elevated linkage disequilibrium. These attributes suggest that the islands discovered here were likely generated by divergence hitchhiking; however, we cannot rule out the possibility that other mechanisms may have produced them. Our results suggest that islands of divergence serve an important role in local adaptation with gene flow and represent a significant advance towards understanding the genetic basis of ecotypic differentiation.
Factors Affecting Bitcoin Price: A Systematic Analysis

Bitcoin (BTC) price has been the subject of criticism over the years due to its relative volatility leading to its first price crash in 2013. With academic and practitioner debate surrounding this form of digital currency, this paper aims to provide a more holistic overview of the economic factors affecting BTC price through conducting a systematic literature review. Based upon a critical review of 51 academic journal articles sourced from various publication databases, this systematic literature review identifies the main factors influencing the price of BTC such as commodities, global indices, and foreign exchange rates and argues that BTC is somewhat isolated from the influence of economic factors. The findings contribute to the existing literature in BTC and price volatility surrounding this digital currency and prove helpful to academic and practitioner debate.
A new Kullback-Leibler VAD for speech recognition in noise

This letter shows an innovative voice activity detector (VAD) based on the Kullback-Leibler (KL) divergence measure. The algorithm is evaluated in the context of the recently approved ETSI standard for distributed speech recognition (DSR). The VAD uses long-term information of the noisy speech signal in order to define a more robust decision rule yielding high accuracy. The mel-scaled filter bank log-energies (FBE) are modeled by means of Gaussian distributions, and a symmetric KL divergence is used for the estimation of the distance between speech and noise distributions. The decision rule is formulated in terms of the average subband KL divergence that is compared to a noise-adaptable threshold. An exhaustive analysis using the AURORA databases is conducted in order to assess the performance of the proposed method and to compare it to existing standard VAD methods.
Better living through conifer removal: A demographic analysis of sage-grouse vital rates

Sagebrush (Artemisia spp.) obligate wildlife species such as the imperiled greater sage-grouse (Centrocercus urophasianus) face numerous threats including altered ecosystem processes that have led to conifer expansion into shrub-steppe. Conifer removal is accelerating despite a lack of empirical evidence on grouse population response. Using a before-after-control-impact design at the landscape scale, we evaluated effects of conifer removal on two important demographic parameters, annual survival of females and nest survival, by monitoring 219 female sage-grouse and 225 nests in the northern Great Basin from 2010 to 2014. Estimates from the best treatment models showed positive trends in the treatment area relative to the control area resulting in an increase of 6.6% annual female survival and 18.8% nest survival relative to the control area by 2014. Using stochastic simulations of our estimates and published demographics, we estimated a 25% increase in the population growth rate in the treatment area relative to the control area. This is the first study to link sage-grouse demographics with conifer removal and supports recommendations to actively manage conifer expansion for sage-grouse conservation. Sage-grouse have become a primary catalyst for conservation funding to address conifer expansion in the West, and these findings have important implications for other ecosystem services being generated on the wings of species conservation.
Numerical Method for 2D Simulation of a Silicon MESFET with a Hydrodynamical Model Based on the Maximum Entropy Principle

We discuss the application of the method of lines for constructing an original numerical algorithm for two-dimensional (2D) simulation of a silicon metal semiconductor field effect transistor (MESFET) with the new hydrodynamical model based on the maximum entropy principle [A. M. Anile and V. Romano, Contin. Mech. Thermodyn. , 11 (1999), pp. 307-325, V. Romano, Contin. Mech. Thermodyn. , 12 (2000), pp. 31-51]. The substantiation of the proposed algorithm is conducted on the example of the model problem for the Poisson equation. The results of numerical experiments are given for different parameters, characterizing silicon MESFET.
An algorithmic approach to structural imaging in dementia

Accurate and timely diagnosis of dementia is important to guide management and provide appropriate information and support to patients and families. Currently, with the exception of individuals with genetic mutations, postmortem examination of brain tissue remains the only definitive means of establishing diagnosis in most cases, however, structural neuroimaging, in combination with clinical assessment, has value in improving diagnostic accuracy during life. Beyond the exclusion of surgical pathology, signal change and cerebral atrophy visible on structural MRI can be used to identify diagnostically relevant imaging features, which provide support for clinical diagnosis of neurodegenerative dementias. While no structural imaging feature has perfect sensitivity and specificity for a given diagnosis, there are a number of imaging characteristics which provide positive predictive value and help to narrow the differential diagnosis. While neuroradiological expertise is invaluable in accurate scan interpretation, there is much that a non-radiologist can gain from a focused and structured approach to scan analysis. In this article we describe the characteristic MRI findings of the various dementias and provide a structured algorithm with the aim of providing clinicians with a practical guide to assessing scans.
Environment Classifiers Extended

This paper proposes and develops the basic theory for a new approach to typing multi-stage languages based a notion of environment classifiers. This approach involves explicit but lightweight tracking – at type-checking time – of the origination environment for future-stage computations. Classification is less restrictive than the previously proposed notions of closedness, and allows for both a more expressive typing of the “run” construct and for a unifying account of typed multi-stage programming. The proposed approach to typing requires making crossstage persistence (CSP) explicit in the language. At the same time, it offers concrete new insights into the notion of levels and in turn into CSP itself. Type safety is established in the simply-typed setting. As a first step toward introducing classifiers to the Hindley-Milner setting, we propose an approach to integrating the two, and prove type preservation in this setting.
Drug transporters: Gatekeepers controlling access of xenobiotics to the cellular interior

In this paper, we evaluate methodologies and null mouse models used to study drug transporter function in vitro and in vivo. P-glycoprotein and MRP null mice have been used to examine many aspects of xenobiotic distribution and bioavailability. Their advantage over conventional models is that they allow the exclusion of transporters from a particular process; however, they cannot be used to study the activity of the transporter that has been deleted. Use of humanized mice permits a logical progression from phenomena in wild-type mice via the effects of removing the mouse transporter to the consequences of replacing it with its human counterpart.
Hepatitis E: an emerging infectious disease.

viremia, as detectable by polymerase chain reaction. The earliest sign of infection is viral replication in the liver, which is detectable by immuno- fluorescence of HEV antigen, immune electron microscopy of HEV particles, or polymerase chain reaction of HEV RNA (43). ALT, ala- nine aminotransferase. (Adapted from Purdy and Krawczynski (69) with permission).
Location Privacy via Private Proximity Testing

We study privacy-preserving tests for proximity: Alice can test if she is close to Bob without either party revealing any other information about their location. We describe several secure protocols that support private proximity testing at various levels of granularity. We study the use of “location tags” generated from the physical environment in order to strengthen the security of proximity testing. We implemented our system on the Android platform and report on its effectiveness. Our system uses a social network (Facebook) to manage user public keys.
Dissecting the contribution of innate and antigen-specific pathways to the breach of self-tolerance observed in a murine model of arthritis

Background: The relative roles of innate immunity and antigen-specific T cells in rheumatoid arthritis remain controversial. Previous studies demonstrated that T-helper type 1 cells of irrelevant antigen specificity (ovalbumin) induced a transient arthritis in BALB/c mice, which recapitulates many of the pre-articular and articular features of human disease and is associated with the emergence of autoreactive T and B-cell responses to joint-specific antigens. However, the mechanisms underlying this phenomenon were unclear. Objectives: The aim of this study was to dissect the relative contribution of innate and heterologous antigen-specific pathways to the breach of self-tolerance and pathology observed in this model and how this may result from modified T and B-cell interactions. Methods: To address this issue, experimental arthritis was elicited either by a non-specific inflammatory stimulus alone, by activation of T cells of an irrelevant specificity or a combination of both. Results: The non-specific inflammatory response generated by lipopolysaccharide led to articular inflammation and cartilage erosion, but did not break tolerance to joint-specific antigens. In contrast, local activation of T cells of an irrelevant specificity produced a similar pathological picture but, in addition, induced T-cell responses to unrelated joint-specific antigens with associated activation of autoreactive B cells. These effects could be further potentiated by the addition of lipopolysaccharide. Conclusion: These data demonstrate that non-specific inflammation alone is insufficient to breach self-tolerance. In contrast, T cells of an irrelevant specificity, when triggered locally in an antigen-specific manner, can breach self-tolerance leading to arthritis and autoantibody production, which can then be amplified in a non-specific manner.