Miracle-dz/UniFAR-FTUs huggingface dataset:
YB-1 regulates tumor growth by promoting MACC1/c-Met pathway in human lung adenocarcinoma

Aberrant overexpression of the transcription/translation factor Y-box-binding protein (YB-1) is associated with poor prognosis of lung adenocarcinoma, however the underlying mechanism by which YB-1 acts has not been fully elucidated. Here, we reported that inhibition of YB-1 diminished proliferation, migration and invasion of lung adenocarcinoma cells. Interestingly, we identified metastasis associated in colon cancer-1 (MACC1) as a target of YB-1. Depletion of YB-1 markedly decreased MACC1 promoter activity and suppressed the MACC1/c-Met signaling pathway in lung adenocarcinoma cells. Additionally, chromatin immunoprecipitation (ChIP) assay demonstrated that YB-1 bound to the MACC1 promoter. Moreover, YB-1 was positively correlated with MACC1, and both proteins were over-expressed in lung adenocarcinoma tissues. The Cox-regression analysis indicated that high YB-1 expression was an independent risk factor for prognosis in enrolled patients. Furthermore, depletion of YB-1 attenuated tumorigenesis in a xenograft mouse model and reduced MACC1 expression in tumor tissues. Collectively, our data suggested that targeting YB-1 suppressed lung adenocarcinoma progression through the MACC1/c-Met pathway and that the high expression of YB-1/MACC1 is a potential prognostic marker in lung adenocarcinoma.
Sampling and Estimation Issues for Annual and Sub‐annual Canadian Business Surveys

A typical Business Register (BR) is mainly based on administrative data files provided by organisations that produce them as a by‐product of their function. Such files do not necessarily yield a perfect Business Register. A good BR should have the following characteristics: (1) It should reflect the complex structures of businesses with multiple activities, in multiple locations or with multiple legal entities; (2) It should be free of duplication, extraneous or missing units; (3) It should be properly classified in terms of key stratification variables, including size, geography and industry; (4) It should be easily updateable to represent the “newer” business picture, and not lag too much behind it. In reality, not all these desirable features are fully satisfied, resulting in a universe that has missing units, inaccurate structures, as well as improper contact information, to name a few defects.
A review of dsb induction data for varying quality radiations.

PURPOSE This short review summarizes the data obtained with various techniques for measuring the yields of double strand breaks (dsb) produced by particle radiations of differing linear energy transfer (LET) in order to obtain relative biological effectiveness (RBE) values. RESULTS AND CONCLUSIONS Studies aimed at understanding the interactions of different types of radiation with cellular DNA have monitored the yields of DNA dsb versus radiation quality. Several techniques have been used to measure dsb yields in mammalian cells, and these include: neutral sedimentation gradients, filter elution and more recently pulsed field gel electrophoresis techniques (PFGE). Recent developments in PFGE have allowed the measurement of both the yields and the distribution of breaks within the genome, which go part of the way to explaining the RBE values close to 1.0 previously measured using other approaches with various radiation qualities. It is clear that future studies to determine the effectiveness of radiations of differing LET must use techniques that determine both yields and distributions of dsb, and assays need to be developed to allow these measurements at biologically relevant doses.
A meta-analysis of research on sensory integration treatment.

OBJECTIVE The purpose of this study was to find whether existing studies of treatment using sensory integration approaches support the efficacy of these approaches. METHOD With meta-analysis, the results of sensory integration efficacy research studies published from 1972 to the present were synthesized and analyzed. Sixteen studies were used to compare sensory integration effect with no treatment (SI/NT), and 16 were used to compare sensory integration effect with alternative treatments (SI/ALT). Overall average effect sizes, comparisons of the effect sizes for different dependent variables, and secondary factors associated with effect size variation were examined. RESULTS The weighted average effect size of SI/NT studies was . 29. However, there was a significant difference between the average effect sizes of the earlier studies (.60) and the more recent studies (.03). Of the outcome measures, larger effect sizes were found in the psychoeducational category (.39) and motor category (.40). Of SI/ALT studies, the average effect size was . 09, not significantly different from zero. CONCLUSION Three central conclusions can be made. First, in the SI/NT comparison, a significant effect was replicated for sensory integration treatment effects in earlier studies, but more recent studies did not show overall positive effects. Second, larger effect sizes were found in psychoeducational and motor categories. Third, sensory integration treatment methods were found to be as effective as various alternative treatment methods.
Improved Detection of Microsatellite Instability in Early Colorectal Lesions

Microsatellite instability (MSI) occurs in over 90% of Lynch syndrome cancers and is considered a hallmark of the disease. MSI is an early event in colon tumor development, but screening polyps for MSI remains controversial because of reduced sensitivity compared to more advanced neoplasms. To increase sensitivity, we investigated the use of a novel type of marker consisting of long mononucleotide repeat (LMR) tracts. Adenomas from 160 patients, ranging in age from 29–55 years old, were screened for MSI using the new markers and compared with current marker panels and immunohistochemistry standards. Overall, 15 tumors were scored as MSI-High using the LMRs compared to 9 for the NCI panel and 8 for the MSI Analysis System (Promega). This difference represents at least a 1.7-fold increase in detection of MSI-High lesions over currently available markers. Moreover, the number of MSI-positive markers per sample and the size of allelic changes were significantly greater with the LMRs (p = 0.001), which increased confidence in MSI classification. The overall sensitivity and specificity of the LMR panel for detection of mismatch repair deficient lesions were 100% and 96%, respectively. In comparison, the sensitivity and specificity of the MSI Analysis System were 67% and 100%; and for the NCI panel, 75% and 97%. The difference in sensitivity between the LMR panel and the other panels was statistically significant (p<0.001). The increased sensitivity for detection of MSI-High phenotype in early colorectal lesions with the new LMR markers indicates that MSI screening for the early detection of Lynch syndrome might be feasible.
A Geometric Analysis of Subspace Clustering with Outliers

This paper considers the problem of clustering a collection of unlabeled data points assumed to lie near a union of lower dimensional planes. As is common in computer vision or unsupervised learning applications, we do not know in advance how many subspaces there are nor do we have any information about their dimensions. We develop a novel geometric analysis of an algorithm named sparse subspace clustering (SSC) [11], which signicantly broadens the range of problems where it is provably eective. For instance, we show that SSC can recover multiple subspaces, each of dimension comparable to the ambient dimension. We also prove that SSC can correctly cluster data points even when the subspaces of interest intersect. Further, we develop an extension of SSC that succeeds when the data set is corrupted with possibly overwhelmingly many outliers. Underlying our analysis are clear geometric insights, which may bear on other sparse recovery problems. A numerical study complements our theoretical analysis and demonstrates the eectiveness of these methods.
Limits on the Abundance of Galactic Planets From 5 Years of PLANET Observations

We search for signatures of planets in 43 intensively monitored microlensing events that were observed between 1995 and 1999. Planets would be expected to cause a short-duration (~1 day) deviation on the smooth, symmetric light curve produced by a single lens. We find no such anomalies and infer that less than one-third of the ~0.3 M☉ stars that typically comprise the lens population have Jupiter mass companions with semimajor axes in the range of 1.5 AU < a < 4 AU. Since orbital periods of planets at these radii are 3-15 yr, the outer portion of this region is currently difficult to probe with any other technique.
Role of oxidative stress in ultrafine particle-induced exacerbation of allergic lung inflammation.

RATIONALE The effects of ultrafine particle inhalation on allergic airway inflammation are of growing interest. The mechanisms underlying these effects are currently under investigation. OBJECTIVES To investigate the role of oxidative stress on the adjuvant activity of inhaled elemental carbon ultrafine particles (EC-UFPs) on allergic airway inflammation. METHODS Ovalbumin-sensitized mice were exposed to EC-UFPs (504 microg/m(3) for 24 h) or filtered air immediately before allergen challenge and systemically treated with N-acetylcysteine or vehicle before and during EC-UFP inhalation. Allergic inflammation was measured up to 1 week after allergen challenge by means of bronchoalveolar lavage, cytokine/total protein assays, lung function, and histology. Isoprostane levels in lung tissue served to measure oxidative stress. Transmission electron microscopy served to localize EC-UFPs in lung tissue and both electrophoretic mobility shift assay and immunohistochemistry to quantify/localize nuclear factor-kappaB (NF-kappaB) activation. MEASUREMENTS AND MAIN RESULTS In sensitized and challenged mice EC-UFP inhalation increased allergen-induced lung lipid peroxidation and NF-kappaB activation in addition to inflammatory infiltrate, cytokine release, and airway hyperresponsiveness. Prominent NF-kappaB activation was observed in the same cell types in which EC-UFPs were detected. N-acetylcysteine treatment significantly reduced the adjuvant activity of EC-UFPs. In nonsensitized or sensitized but not challenged mice EC-UFP exposure induced a moderate increase in isoprostanes but no significant effect on other parameters of lung inflammation. CONCLUSIONS Our findings demonstrate a critical role for oxidative stress in EC-UFP-induced augmentation of allergen-induced lung inflammation, where EC-UFP exposure has potentiating effects in lung allergic inflammation. Our data support the concept that allergic individuals are more susceptible to the adverse health effects of EC-UFPs.
Knowledge Guided Disambiguation for Large-Scale Scene Classification With Multi-Resolution CNNs

Convolutional neural networks (CNNs) have made remarkable progress on scene recognition, partially due to these recent large-scale scene datasets, such as the Places and Places2. Scene categories are often defined by multi-level information, including local objects, global layout, and background environment, thus leading to large intra-class variations. In addition, with the increasing number of scene categories, label ambiguity has become another crucial issue in large-scale classification. This paper focuses on large-scale scene recognition and makes two major contributions to tackle these issues. First, we propose a multi-resolution CNN architecture that captures visual content and structure at multiple levels. The multi-resolution CNNs are composed of coarse resolution CNNs and fine resolution CNNs, which are complementary to each other. Second, we design two knowledge guided disambiguation techniques to deal with the problem of label ambiguity: 1) we exploit the knowledge from the confusion matrix computed on validation data to merge ambiguous classes into a super category and 2) we utilize the knowledge of extra networks to produce a soft label for each image. Then, the super categories or soft labels are employed to guide CNN training on the Places2. We conduct extensive experiments on three large-scale image datasets (ImageNet, Places, and Places2), demonstrating the effectiveness of our approach. Furthermore, our method takes part in two major scene recognition challenges, and achieves the second place at the Places2 challenge in ILSVRC 2015, and the first place at the LSUN challenge in CVPR 2016. Finally, we directly test the learned representations on other scene benchmarks, and obtain the new state-of-the-art results on the MIT Indoor67 (86.7%) and SUN397 (72.0%). We release the code and models at https://github.com/wanglimin/MRCNN-Scene-Recognition.
Mucuna pruriens attenuates haloperidol-induced orofacial dyskinesia in rats

Neuroleptic-induced tardive dyskinesia (TD) is a motor disorder of the orofacial region resulting from chronic neuroleptic treatment. The agents improving dopaminergic transmission improve TD. Mucuna pruriens seed contains levodopa and amino acids. The effect of methanolic extract of M. pruriens seeds (MEMP) was studied on haloperidol-induced TD, alongside the changes in lipid peroxidation, reduced glutathione, superoxide dismutase (SOD) and catalase levels. The effect of MEMP was also evaluated in terms of the generation of hydroxyl and 1,1-diphenyl,2-picrylhydrazyl (DPPH) radical. MEMP (100 and 200 mg kg−1) inhibited haloperidol-induced vacuous chewing movements, orofacial bursts and biochemical changes. MEMP also inhibited hydroxyl radical generation and DPPH. The results of the present study suggest that MEMP by virtue of its free radical scavenging activity prevents neuroleptic-induced TD.
Lipoic Acid Use and Functional Outcomes after Thrombolysis in Patients with Acute Ischemic Stroke and Diabetes

Background Alpha-lipoic acid (aLA) is a strong antioxidant commonly used for treating diabetic polyneuropathy. Previously, we demonstrated the neurorestorative effects of aLA after cerebral ischemia in rats. However, its effects on patients with stroke remain unknown. We investigated whether patients treated with aLA have better functional outcomes after acute ischemic stroke (AIS) and reperfusion therapy than patients not receiving aLA. Methods In this retrospective study of 172 prospectively registered patients with diabetes and AIS treated with tissue plasminogen activator (tPA), we investigated the relationship between aLA use and functional outcome both after 3 months and after 1 year. The functional outcomes included occurrence of hemorrhagic transformation (HT), early neurological deterioration (END), and early clinical improvement (ECI). Favorable outcomes were defined as modified Rankin Scale (mRS) scores of 0–2. Results Of the 172 patients with AIS and diabetes, 47 (27.3%) used aLA. In the entire cohort, favorable outcomes occurred at significantly higher rates both at 3 months and at 1 year in those treated with aLA. The risks for END and HT were lower and the occurrence of ECI was higher in patients treated with aLA. In multivariable analysis, aLA use was associated with favorable outcomes both at 3 months and at 1 year. Age, HT, and increased National Institutes of Health Stroke Scale scores were negative predictors of a favorable outcome. Conclusions The use of aLA in patients with AIS and diabetes who are treated with tPA is associated with favorable outcomes. These results indicate that aLA could be a useful intervention for the treatment of AIS after reperfusion therapy.
Chondroitin Sulfate Proteoglycans in the Nervous System: Inhibitors to Repair

Chondroitin sulfate proteoglycans (CSPGs) are widely expressed in the normal central nervous system, serving as guidance cues during development and modulating synaptic connections in the adult. With injury or disease, an increase in CSPG expression is commonly observed close to lesioned areas. However, these CSPG deposits form a substantial barrier to regeneration and are largely responsible for the inability to repair damage in the brain and spinal cord. This review discusses the role of CSPGs as inhibitors, the role of inflammation in stimulating CSPG expression near site of injury, and therapeutic strategies for overcoming the inhibitory effects of CSPGs and creating an environment conducive to nerve regeneration.
Thermotropic and Barotropic Phase Behavior of Phosphatidylcholine Bilayers

Bilayers formed by phospholipids are frequently used as model biological membranes in various life science studies. A characteristic feature of phospholipid bilayers is to undergo a structural change called a phase transition in response to environmental changes of their surroundings. In this review, we focus our attention on phase transitions of some major phospholipids contained in biological membranes, phosphatidylcholines (PCs), depending on temperature and pressure. Bilayers of dipalmitoylphosphatidylcholine (DPPC), which is the most representative lipid in model membrane studies, will first be explained. Then, the bilayer phase behavior of various kinds of PCs with different molecular structures is revealed from the temperature–pressure phase diagrams, and the difference in phase stability among these PC bilayers is discussed in connection with the molecular structure of the PC molecules. Furthermore, the solvent effect on the phase behavior is also described briefly.
Serum levels of soluble CD30 molecule (Ki‐1 antigen) in Hodgkin's disease: relationship with disease activity and clinical stage

In all cases of Hodgkin's disease (HD) Reed‐Sternberg (RS) cells express the CD30 antigen. It has been recently demonstrated that this molecule can be released from the cell membrane of CD30+ neoplastic cells in a soluble form (sCD30), detectable in culture supernatants and body fluids. In this paper we investigated by an immunoassay the serum levels of sCD30 in 58 patients with HD, in order to define the possible relationship of this molecule to the clinical and pathological findings. sCD30 molecule was found at detectable levels in 24 out of 50 patients (48%) with active disease, whereas it was always absent in control sera and in cases in complete remission. Among the patients with active HD, the incidence and mean values of detectable levels (±SEM) of sCD30 were higher in cases with progressive or relapsing disease (61.5%, mean 458±190 U/ml) as compared to those at presentation (43.2%, mean 116 ± 3 3 U/ml). Among the cases at presentation, detectable levels were observed more often in patients with advanced stages (III+IV: 61%) and constitutional symptoms (‘B’: 61‐5%) than in early stages (I+11: 26%) and without symptoms (‘A’: 33.3%). In addition, higher mean values were found in stages III+IV (182±60 U/ml) and in ‘B’cases (208±73 U/ml) than in stages I+II (65 ± 30 U/ml) or ‘A’patients (64 ± 26 U/ ml).
The Subtle Sound of Learning: What Are the Roles of the Self-esteem, Decision-Making, and Social Skills in Adolescents' Academic Performance?

Many researchers have analyzed the relationship among self-esteem, decision-making, and interpersonal behavior in Italian adolescents. However, the purpose of those studies was to determine if adolescents with high or low academic performance present different levels of self-esteem, decision-making, and interpersonal behavior. One hundred students, equally divided into two groups (high vs. low academic performance), were selected. They were asked to fill out self-analyzing questionnaires in order to estimate their perceptions of their self-esteem, decision-making styles, and social abilities. As expected, low academic performance was associated with lower self-esteem and lower decision-making abilities, while students with high academic performance showed higher self-esteem and more functional decision-making styles. Sample characteristics did not allow to generalize the results; however, data analysis confirmed the necessity to organize education training for teachers that could be useful to increase not only academic competences but also individual competences, which seem to be closely linked together.
Convex and scalable weakly labeled SVMs

In this paper, we study the problem of learning from weakly labeled data, where labels of the training examples are incomplete. This includes, for example, (i) semi-supervised learning where labels are partially known; (ii) multi-instance learning where labels are implicitly known; and (iii) clustering where labels are completely unknown. Unlike supervised learning, learning with weak labels involves a difficult Mixed-Integer Programming (MIP) problem. Therefore, it can suffer from poor scalability and may also get stuck in local minimum. In this paper, we focus on SVMs and propose the WELLSVM via a novel label generation strategy. This leads to a convex relaxation of the original MIP, which is at least as tight as existing convex Semi-Definite Programming (SDP) relaxations. Moreover, the WELLSVM can be solved via a sequence of SVM subproblems that are much more scalable than previous convex SDP relaxations. Experiments on three weakly labeled learning tasks, namely, (i) semi-supervised learning; (ii) multi-instance learning for locating regions of interest in content-based information retrieval; and (iii) clustering, clearly demonstrate improved performance, and WELLSVM is also readily applicable on large data sets.
[Expression of the cerbB-2 (HER-2/neu) oncoprotein in prostatic adenocarcinoma].

OBJECTIVES Our aim is to determine the expression of the cerbB-2 oncoprotein in prostate cancers using an immunohistochemistry staining and to compare these results with several clinical and histological prognostic factors. METHODS An immunohistochemical staining using the cerbB-2 monoclonal antibody (Dako) was performed in 32 radical prostatectomy specimens diagnosed of adenocarcinoma. The intensity of cerbB-2 expression was evaluated with a scale that variated from 0 (no staining) to 3+ (strong complete membrane staining) according to published guidelines. Association of cerbB-2 index immunoreactivity with clinical and histological prognostic factors was examined. RESULTS Definite positive membranous staining was detected in 14 of 32 neoplastic cases (44%). Such overexpression was correlated with higher Gleason grade (p=0.04) and higher stage of disease (p=0.038). CONCLUSIONS 1) This study shows that 44% of all prostate cancer express the cerbB-2 oncoprotein with immunohistochemical technique. 2) These findings suggest that is necessary to standardize the immunohistochemical staining procedure with cerbB-2 in prostate adenocarcinoma. 3) The level of cerbB-2 expression was correlated with Gleason grade and clinical stage.
Moral Intelligence 2.0: Enhancing Business Performance and Leadership Success in Turbulent Times

Foreword by Richard Leider xiii Foreword to Previous Edition by Richard E. Boyatzis xvi Introduction xxix Part I: Moral Intelligence Chapter 1: Good Business 3 Chapter 2: Born to Be Moral 35 Chapter 3: Your Moral Compass 57 Chapter 4: Staying True to Your Moral Compass 81 Part II: Developing Moral Skills Chapter 5: Integrity 97 Chapter 6: Responsibility 113 Chapter 7: Compassion and Forgiveness 125 Chapter 8: Emotions 135 Chapter 9: Making Moral Decisions 157 Part III: Moral Leadership Chapter 10: The Moral Leader 181 Chapter 11: Leading Large Organizations 197 Chapter 12: Moral Intelligence for the Entrepreneur 223 Epilogue: Becoming a Global Moral Leader 243 Appendix A: Strengthening Your Moral Skills 251 Appendix B: Moral Competency Inventory (MCI) 263 Appendix C: Scoring the MCI 271 Appendix D: Interpreting Your MCI Scores 277