Miracle-dz/UniFAR-FTUs huggingface dataset:
Scaffolding in low-income mother-child dyads: Relations with joint attention and dyadic reciprocity

This study was conducted to further extend scaffolding research to low-income dyads because living in poverty may serve as a risk factor for experiencing difficulties in social and cognitive development during childhood. Scaffolding was examined in the context of mother-toddler dyads’ (N = 56) performance of a routine feeding task that was difficult for 2-year-olds to complete independently. Both verbal and nonverbal behaviours were microanalytically coded in order to characterise the successive scaffolding strategies by mothers, and their children’s responses. Also, scaffolding data were compared to data on joint attention and dyadic reciprocity obtained from a free-play task. Results show that mothers’ use of constructive verbal strategies during the feeding task was positively associated with joint attention and mother-initiated dyadic reciprocity, both of which may be viewed as indices of maternal sensitivity. Thus, the provision of verbal assistance may be one mark of maternal sensitivity during scaffolding in low-income dyads.
Hydra-MIP : Automated Algorithm Configuration and Selection for Mixed Integer Programming

State-of-the-art mixed integer programming (MIP) solvers are highly parameterized. For heterogeneous and a priori unknown instance distributions, no single parameter configuration generally achieves consistently strong performance, and hence it is useful to select from a portfolio of different configurations. HYDRA is a recent method for using automated algorithm configuration to derive multiple configurations of a single parameterized algorithm for use with portfolio-based selection. This paper shows that, leveraging two key innovations, HYDRA can achieve strong performance for MIP. First, we describe a new algorithm selection approach based on classification with a non-uniform loss function, which significantly improves the performance of algorithm selection for MIP (and SAT). Second, by modifying HYDRA’s method for selecting candidate configurations, we obtain better performance as a function of training time.
Organizational Factors that Influence University-Based Researchers’ Engagement in Knowledge Transfer Activities

Knowledge transfer has become a priority for universities and other publicly funded research institutions. However, researchers working in these settings report certain structural barriers to engaging in knowledge translation activities. This article describes these barriers, situating them in the disjunction between current expectations and the historical tradition of disciplinary authority in academia. The authors review some of the organizational solutions that have been proposed to address this disjunction. This analysis of barriers and solutions suggests that five domains of organizational policy and practice—promotion and tenure, resources and funding, structures, knowledge transfer orientation, and documentation—may be critical to promoting researchers’engagement in knowledge transfer.
Popular Explanations of Poverty: A Critical Discussion of Empirical Research

Abstract Various authors point to the connection between public perceptions of poverty and institutionalised strategies of dealing with the poor. The way the general public perceives the poor, and especially the causes of poverty, is generally assumed to have a profound influence on the legitimacy of anti-poverty policies. Yet studies on popular perceptions of and attributions for poverty are relatively infrequent. Moreover, a considerable share of existing research appears conceptually and/or methodologically inadequate. This article provides a critical review of existing literature that is interwoven into the discussion of the two most common approaches to studying lay poverty attributions: the factor analytical approach and the forced-choice-question approach. With respect to the latter, we present an empirical analysis and interpretation of the four response categories that constitute the core of the forced-choice question included in Eurobarometer.
Calcium/calmodulin-stimulated phosphorylation of photoreceptor proteins in Limulus

Abstract Calcium (Ca2+) is thought to play a major role in the photoresponse of both vertebrates and invertebrates, but the mechanisms through which Ca2+ exerts its effects are unclear. In many systems, some effects of Ca2+ on cellular processes are thought to be mediated via activation of calcium/calmodulin protein kinase (CaCAM-PK) and the phosphorylation of specific proteins. Thus, protein substrates for CaCAM-PK in photoreceptor cells may be important in mediating the effects of Ca2+ on the photoresponse. In this study, we identify eight substrates for CaCAM-PK found in both the ventral and lateral eyes of Limulus. We focus on a characterization of one of these, a 46-kD substrate. We show that its subcellular distribution in ventral photoreceptors and its isoelectric forms are identical to the 46-kD light-stimulated phosphoprotein (46A) described by Edwards et al. (1989). Furthermore, we present evidence that 46A is unique to photoreceptor cells, and that it is present throughout the cell. Based on the results of this study, and the previous study by Edwards et al. (1989), we propose that 46A is involved in mediating the effects of Ca2+ on Limulus photoreceptor cell function, and that it may be involved in dark adaptation.
Confirmatory Factor Analysis of the Moral Foundations Questionnaire

The Moral Foundations Questionnaire (MFQ) measures five universal moral foundations of Harm/care, Fairness/reciprocity, Ingroup/loyalty, Authority/respect, and Purity/sanctity. This study provided an independent test of the factor structure of the MFQ using Confirmatory Factor Analysis in a large New Zealand national probability sample (N = 3,994). We compared the five-factor model proposed by Moral Foundations Theory against alternative single-factor, two-factor, three-factor, and hierarchical (five foundations as nested in two second order factors) models of morality. The hypothesized five-factor model proposed by Moral Foundations Theory provided a reasonable fit. These findings indicate that the five-factor model of moral foundations holds in New Zealand, and provides the first independent test of the factor structure of the Moral Foundations Questionnaire.
Systemic versus Topical Fluoride

The actual mechanism of fluoride action is still a subject of debate. A dogma has existed for many decades, that fluoride has to be ingested and acts mainly pre-eruptively. However, recent studies concerning the systemic effect of fluoride supplementation concluded that the caries-preventive effect of fluoride is almost exclusively posteruptive. Moreover, epidemiologists have cast doubt on the validity of the ‘old’ studies dealing with fluoride use. The concept of the posteruptive fluoride effect is supported by in vitro and in situ investigations demonstrating that the mode of action of fluoride can be attributed mainly to its influence on de- and remineralization kinetics of dental hard tissues. Therefore, topical fluoride application (e.g. in the form of fluoridated dentifrices) should be encouraged. There are still important questions open that need to be answered despite existing knowledge about the caries-preventive effect of fluoride.
Does Serotonin Play a Role in Epilepsy?

Studies in experimental models have suggested a potential role for serotonergic transmission in epilepsy, and interest in this research has been increased by the development of positron emission tomography (PET) ligands that can be used to study 5-hydroxytryptamine (5-HT) receptors and transporters. The serotonergic system is very complex. At least 13 distinct G protein–coupled 5-HT receptors and one ligand-gated ion channel receptor (5-HT3) are divided into seven distinct classes (5-HT1 to 5-HT7) (1). The receptors vary widely in their distribution and effects, innervating vascular structures and gut smooth muscle as well as neuronal tissue. Several receptor subtypes may be relevant to epilepsy.
Passing By: Gender and Public Harassment

Catcalls, wolf whistles, verbal slurs, pinches, stalking - virtually every woman has experienced some form of unwanted public attention by men. Off the street, in semi-public places such as restaurants and department stores, women often suffer the insult of being passed over by employees eager to serve men. How pervasive is this behavior? How dangerous can it be? And what, if anything, should be done about it? "Passing By", an illuminating, unsettling work, explores the important yet little-examined issue of gender-related public harassment. Based on extensive research - including in-depth interviews with nearly five-hundred midwestern women and men - it documents the many types of indignity visited on women in public places. As Carol Brooks Gardner demonstrates, these indignities cross all lines of age, class, and ethnicity and follow a typical pattern whereby a man or men take advantage of a woman's momentary or permanent vulnerability. Beyond describing the scope and variety of harassing behaviors, the book investigates the different ways women and men respond to and interpret them. Gardner concludes, provocatively, that gender-based public harassment exerts a powerful control over women's feelings of comfort in the towns and communities where they live and work. Further, she defines it as a new category of social problem that shares much in common with sexual harassment and, in its more menacing form, requires legal remedy.
Introducing the OCEAN.20: A 20-Item Five-Factor Personality Measure Based on the Trait Self-Descriptive Inventory

We report on the development of a short measure of the Big Five model of personality. In Study 1, we created three versions (15, 20, and 25 items) of the Trait Self-Descriptive Inventory (TSD), a Big Five personality measure developed by Tupes and Christal (1992). These short measures were confirmed using confirmatory factor analysis in Study 2. Studies 3 and 4 compared the predictive validity of a 75-item TSD against that of the shortened scales. Results suggest that a 20-item version (the OCEAN.20) is a useful, short, and psychometrically sound measure of the Big Five suitable for use in organizational research.
Reduced Bone Mineral Density in SOCS-2-Deficient Mice

Suppressor of cytokine signaling-2 (SOCS-2) is a member of the suppressor of cytokine signaling family, implicated in the negative regulation of cytokine action through inhibition of the Janus kinase (JAK) signal transducers and activators of transcription (STAT) signal transduction pathway. We have previously reported that SOCS-2−/− mice display an increased longitudinal skeletal growth associated with a deregulated GH/IGF-I signaling. The aim of the present study was to determine the role of SOCS-2 in the regulation of bone mineral density (BMD). Dual x-ray absorptiometry (DXA) analyses demonstrated that the areal BMD of the tibia was reduced in both 4-wk-old (−8.6%) and 15-wk-old (−6.0%) SOCS 2−/− mice compared with wild-type (WT) mice. The trabecular volumetric BMD, as measured by peripheral quantitative computerized tomography (pQCT) in the metaphyseal region of the distal femur, was reduced in both 4-wk-old (−10%) and 15-wk-old (−32%) SOCS 2−/− mice compared with WT mice. pQCT analyses in the diaphyseal region of tibia also revealed that the cortical volumetric BMD was reduced in both 4-wk-old (−7%) and 15-wk-old (−3%) SOCS 2−/− mice. The cortical cross-sectional area was reduced in 4-wk-old but not in 15-wk-old SOCS 2−/− mice. In conclusion, SOCS-2 inactivation results in reduced trabecular and cortical volumetric BMD. These effects are not consistent with an augmented GH/IGF-I signaling and, therefore, the mechanism behind the reduced BMD remains to be elucidated.
Plasma vitamin C and food choice in the third Glasgow MONICA population survey

STUDY OBJECTIVE To determine the contribution of different foods to the estimated intakes of vitamin C among those differing in plasma vitamin C levels, and thereby inform dietary strategies for correcting possible deficiency. DESIGN Cross sectional random population survey. SETTING North Glasgow, Scotland, 1992. PARTICIPANTS 632 men and 635 women, aged 25 to 74 years, not taking vitamin supplements, who participated in the third MONICA study (population survey monitoring trends and determinants of cardiovascular disease). MEASUREMENTS AND MAIN RESULTS Dietary and sociodemographic information was collected using a food frequency and lifestyle questionnaire. Plasma vitamin C was measured in non-fasted venous blood samples and subjects categorised by cut points of 11.4 and 22.7 μmol/l as being of low, marginal or optimal vitamin C status. Food sources of dietary vitamin C were identified for subjects in these categories. Plasma vitamin C concentrations were compared among groups classified according to intake of key foods. More men (26%) than women (14%) were in the low category for vitamin C status; as were a higher percentage of smokers and of those in the older age groups. Intake of vitamin C from potatoes and chips (fried potatoes) was uniform across categories; while the determinants of optimal versus low status were the intakes of citrus fruit, non-citrus fruit and fruit juice. Optimal status was achieved by a combined frequency of fruit, vegetables and/or fruit juice of three times a day or more except in older male smokers where a frequency greater than this was required even to reach a marginal plasma vitamin C level. CONCLUSION Fruit, vegetables and/or fruit juice three or more times a day increases plasma vitamin C concentrations above the threshold for risk of deficiency.
Retreatment of patients with chronic hepatitis C

Significant advances have been made in the treatment of chronic hepatitis C virus (HCV) infection during the past 5 years. As a consequence, there is continuing enthusiasm for retreating patients who did not achieve sustained virological response (SVR) with previous therapy. Retreatment of non‐responders to standard interferon monotherapy using interferon and ribavirin has yielded SVR rates of 12% to 15%. Retreatment with peginterferon and ribavirin has been more effective; achieving SVR rates of 34% to 40%. Retreatment of patients who relapsed after interferon monotherapy using standard interferon and ribavirin yielded SVR rates of 47%, whereas retreatment with peginterferon and ribavirin resulted in an SVR rate of about 60%. The major factors associated with a higher likelihood of an SVR after retreatment include previous relapse, previous treatment with interferon monotherapy, HCV genotypes 2 or 3, lower serum levels of HCV RNA, and having a significant decrease in HCV RNA levels during the initial course of therapy. These results help to focus retreatment with peginterferon and ribavirin on subsets of patients who are most likely to benefit. (HEPATOLOGY 2002;36:S128‐S134).
Common and uncommon ground: Social and structural factors in codeswitching

ABSTRACT The social forces affecting the performance of codeswitching (CS) may be distinguished from those factors controlling its basic structure, with which they interact. The constraints on possible patterns in CS are largely under innately based controls. These constraints are presented here in a model of intrasentential CS, and their validity is tested against findings of CS practices in a number of communities; all options can be accounted for under the model. Thus the options for CS structures seem universally set; but community-specific or group-specific social forces may determine which permissible patterns are preferred. In addition, micro-level, discourse-based factors may prompt individuals to produce certain CS structures. A second model of the social motivations for CS helps explain both the macro- and micro-level preferences. (Bilingualism, codeswitching, language contact, socio-pragmatics)
Toward a Feminist Theory of Public Relations

In this study, I develop a feminist theory of public relations by explaining discrimination against female practitioners and positing an agenda for change. Thirty-seven "long" interviews and three focus groups conducted with female practitioners revealed that major obstacles for women are marginalization of public relations, problems stemming from male dominance at work, women's "balancing" act between career and family, and gender stereotypes. Solutions for overcoming barriers are proposed for society, organizations, public relations, and women.
Association of -308 TNF-alpha promoter polymorphism with viral load and CD4 T-helper cell apoptosis in HIV-1 infected black South Africans

Objective. To determine whether the -308 TNF-α promoter polymorphism is associated with markers of HIV progression in the South African population. Methods. Polymerase chain reaction-restriction fragment length polymorphism was used to detect the -308 TNF-α polymorphism in 75 patients and 76 healthy controls. Serum TNF-α concentrations were measured using ELISA in each cohort. CD4+ T cell apoptosis and HIV-1 RNA viral load were determined using Annexin-V-FITC assay and Nuclisens Easy Q HIV-1 assay respectively. CD4 + T cell counts were measured flow cytometrically. Results. The frequency of -308 G allele was similar in the HIV-1 and control cohorts. The -308GG genotype was associated with lower TNF-α concentrations and markers of increased HIV progression indicated by higher TH lymphocyte apoptosis, lower TH lymphocyte count and higher plasma viral load, irrespective of treatment. Conclusion. The presence of the TNF-α -308 G allele in HIV-1 patients may be associated with increased risk of HIV-1 progression. Further research is required to investigate the nature of this association. S Afr J HIV Med 2012;13(2):72-77.
Interviewer and Interviewee Relationships Between Women

In this research note, I readdress the discussion of relationships in women interviewing women initiated by Ann Oakley in 1981. On examining existing feminist literature on interviewing relationships, I seek to further explore the differences of power relationships between women interviewers and interviewees. Based on my own experience of interviewing peers - academic mothers in both China and the UK - I argue that both the interviewer and interviewee's perceptions of social, cultural and personal differences have an impact on the power relationship in the interview, which is not simply an issue of quality of the interview, but the dynamics between the interview pair.
Santiago de Chile: antecedentes demográficos, expansión urbana y conflictos

Cuando la expansion de Santiago se efectuo sobre los sectores rurales circundantes y tambien, en los ultimos decenios, en poligonos altos en busca de mejores condiciones ambientales y de calidad de vida, tambien impensadamente, se efectuo hacia areas de mayor riesgo. La ciudad ha cuadruplicado su superficie en los ultimos 50 anos y se acerca al limite de su capacidad de carga, presionado por la ocupacion de areas morfodinamicamente inestables. Son, por lo tanto, motivo de especial preocupacion los desastres asociados en parte a procesos naturales, a los que estan expuestas ciudades como Santiago, con una expansion asociada a un proceso de desplanificacion activado desde 1979 y que dio termino a los 50 anos del Estado Planificador (1929-1979).
Low Frequency of Circulating CD8+ T Stem Cell Memory Cells in Chronic Chagasic Patients with Severe Forms of the Disease

Background CD8+ T cells have been shown to play a crucial role in Trypanosoma cruzi infection. Memory CD8+ T cells can be categorised based on their distinct differentiation stages and functional activities as follows: stem cell memory (TSCM), central memory (TCM), transitional memory (TTM), effector memory (TEM) and terminal effector (TTE) cells. Currently, the immune mechanisms that control T. cruzi in the chronic phase of the infection are unknown. Methodology/Principal Findings To characterise the CD8+ T cell subsets that could be participating in the control of T. cruzi infection, in this study, we compared total and T. cruzi-specific circulating CD8+ T cells with distinctive phenotypic and functional features in chronic chagasic patients (CCPs) with different degrees of cardiac dysfunction. We observed a decreased frequency of total TSCM along with an increased frequency of TTE in CCPs with severe disease. Antigen-specific TSCM cells were not detectable in CCPs with severe forms of the disease. A functional profile of CD8+ T cell subsets among CCPs revealed a high frequency of monofunctional CD8+ T cells in the most severe patients with IFN-γ+- or TNF-α+-producing cells. Conclusions/Significance These findings suggest that CD8+ TSCM cells may be associated with the immune response to T. cruzi and outcome of Chagas disease, given that these cells may be involved in repopulating the T cell pool that controls infection.
Repeated hyperventilation causes peripheral airways inflammation, hyperreactivity, and impaired bronchodilation in dogs.

Winter athletes have an increased incidence of asthma, suggesting that repetitive hyperventilation with cold air may predispose individuals to airways disease. We used a canine model of exercise-induced hyperpnea to examine the effects of repeated hyperventilation with cool, dry air (i.e., dry air challenge [DAC]) on peripheral airway resistance (Rp), reactivity, and inflammation. Specific bronchi were exposed to a single DAC on five consecutive days. Rp and Delta Rp to aerosolized histamine, intravenous histamine, or hypocapnia were measured daily. Bronchoalveolar lavage fluid (BALF) was obtained on the fifth day. Rp increased from 0.70 +/- 0.08 to 1.13 +/- 0.22 cm H(2)O/ml/s (n = 25) 24 h after the first DAC, rose to 1.49 +/- 0.24 cm H(2)O/ml/s by Day 3, and remained elevated throughout the remainder of the protocol. Repeated DAC increased reactivity to hypocapnia and intravenous histamine. Intravenous salbutamol failed to reduce Rp as effectively in challenged airways (111% of Day 1 baseline) as in naive airways (54% of baseline). Repeated DAC caused increased BALF neutrophils, eosinophils, and sulfidopeptide leukotrienes. We conclude that repeated DAC causes peripheral airways inflammation, obstruction, hyperreactivity, and impaired beta-agonist-induced relaxation. This suggests that other mechanisms in addition to increased smooth muscle tone may contribute to the development of repetitive hyperventilation-induced bronchial obstruction and hyperreactivity.
On the occur-check-free PROLOG programs

In most PROLOG implementations, for efficiency occur-check is omitted from the unification algorithm. This paper provides natural syntactic conditions that allow the occur-check to be safely omitted. The established results apply to most well-known PROLOG programs, including those that use difference lists, and seem to explain why this omission does not lead in practice to any complications. When applying these results to general programs, we show their usefulness for proving absence of floundering. Finally, we propose a program transformation that transforms every program into a program for which only the calls to the built-in unification predicate need to be resolved by a unification algorithm with the occur-check.