Miracle-dz/UniFAR-FTUs huggingface dataset:
Learning with Recency Bias

We examine the long-run implication of two models of learning with recency bias: recursive weights and limited memory. We show that both models generate similar beliefs, and that both have a weighted universal consistency property. Using the limited memory model we are able to produce learning procedures that are both weighted universally consistent and converge with probability one to strict Nash equilibrium, the rst example of which we are aware of learning procedures that have this convergence property and also have desirable properties for the individual agents who use them. JEL Classi cation Numbers: 001,002
DISCRIMINATING CROPPING PATTERNS FOR THE U.S. CENTRAL GREAT PLAINS REGION USING TIME-SERIES MODIS 250-METER NDVI DATA - PRELIMINARY RESULTS

Agricultural practices are continually changing at various spatial and temporal scales in response to local management decisions and environmental factors. However, few regional scale land use/land cover (LULC) classifications have focused on characterizing the agricultural sector, particularly on a regular basis to reflect croprelated land use changes that occur from year to year. More detailed and timely LULC data sets are needed for the Central Great Plains region to better understand the role and consequences of cropping practices on climate change issues that potentially threaten the region’s long-term agriculturally sustainability. Time-series MODIS (Moderate Resolution Imaging Spectroradiometer) 250 -meter NDVI (Normalized Difference Vegetation Index) was evaluated to determine if major crop types (alfalfa, corn, sorghum, soybeans, and winter wheat) and crop-related land use practices (irrigation, fallow, and double cropping) in the Central Great Plains could be discriminated based on spectral-temporal differences. Median time-series NDVI curves were calculated for each crop class based on hundreds of field sites and the class’ curves were compared for spectral-temporal differences. Specific crop types and irrigated and non-irrigated crops were discriminated based on differences in their median NDVI curves. Fallow, wheat-summer fallow, and double cropping practices were also identified based on their unique spectral-temporal characteristics. Regional differences in median NDVI curves were found for individual crop types. These regional curves appear to be related to differences in annual precipitation, growing season length, and planting dates. Timeseries MODIS’ 250-meter data appears to have the spatial, spectral, and temporal resolutions necessary to characterize relatively detailed regional-scale cropping practices on a repetitive basis.
Diversity of Layer 5 Pyramidal Cells in the Prefrontal Cortex of the Rhesus Monkey : In Vitro Slice Studies

Whole cell patch clamp recordings were employed to characterize the electrophysiological properties of layer 5 pyramidal cells in slices of the prefrontal cortex (Area 46) of the rhesus monkey. Four electrophysiologically distinct cell types were discriminated based on distinctive repetitive action potential (AP) firing patterns and single AP characteristics: regular-spiking slowly-adapting type-1 cells (RS1; 62%), regular spiking slowly-adapting type-2 cells (RS2; 18%), regular spiking fast-adapting cells (FA; 15%), and intrinsically bursting cells (IB; 5%). These cells did not differ with regard to their location in layer 5 nor in their dendritic morphology. In RS1 cells, AP threshold and amplitude did not change significantly during a 2 second spike train, whereas in RS2 and FA cells AP threshold increased significantly and AP amplitude decreased significantly during the train. In FA cells, complete adaptation of AP firing was observed within 600 ms. IB cells displayed an all-or-none burst of 3-6 APs, followed by RS1-type firing behavior. RS1 cells could be further subdivided into 3 subtypes. Low threshold spiking (LTS) RS1 cells exhibited an initial doublet riding on a depolarizing potential at the onset of a spike train and a prominent depolarizing afterpotential (DAP); intermediate RS1 cells (IM) exhibited a DAP, but no initial doublet, and non-LTS RS1 cells exhibited neither a DAP nor an initial doublet. RS2 and FA cells did not exhibit a DAP or initial doublets. The distinctive firing patterns of these diverse layer 5 pyramidal cells may reflect different roles played by these cells in the mediation of subcortical neuronal activity by the dorsolateral PFC. Page 2 of 48
Sertoli Cell Proliferations of the Infantile Testis: An Intratubular Form of Sertoli Cell Tumor?

We report on six boys with intratubular Sertoli cell proliferations (ISCPs), studied by routine histologic methods, electron microscopy, and immunohistochemistry of anti-müllerian hormone (AMH), inhibin &agr;-subunit, 3&bgr;-hydroxysteroid dehydrogenase (3&bgr;-HSD), proliferative cellular nuclear antigen, and p53, and carefully followed for extended periods with periodic clinical examinations, testicular ultrasonographies, and determinations of serum levels of AMH and inhibin B. Peutz–Jeghers syndrome was found in four of six patients, and gynecomastia occurred in five of six patients. One boy had isosexual pseudoprecocity. ISCPs were observed as multiple foci of seminiferous tubules with large and proliferated Sertoli cells replacing germ cells and limited by the basement membrane. Mitotic figures, atypia, and/or interstitial invasion were not observed. Bilateral ISCPs were the only pathologic finding in three patients (patient nos. 1–3) and were associated with a microscopic tumor that resembled a large-cell calcifying Sertoli cell tumor (LCCSCT) in a fourth patient (patient no. 4). In the two remaining patients (patient nos. 5 and 6) ISCPs and LCCSCT were found in both testes. Ultrastructural examination showed large Sertoli cells, with round nuclei, sparse organelles, and some glycogen. Inhibin &agr;-subunit immunolocalization was positive in the five patients in whom it was determined (patient nos. 2–6), AMH was positive in those ISCPs associated with tumors (patient nos. 4–6) and negative in isolated ISCPs (patient nos. 2 and 3); 3&bgr;-HSD and PCNA were variable, and p53 was negative in all ISCPs. Patient nos. 1–4 have been followed for 2–19 years. One of them is currently entering puberty, the other two have already completed puberty and have testes of normal size, and the remaining one is an adult with clinically normal testes and sperm production. None of these patients had evidence of tumor development during follow-up as shown by serial ultrasonographies and serum levels of AMH and inhibin B. Patient nos. 5 and 6 who had bilateral ISCPs and LCCSCT were orchidectomized and evolved for 2–10 years after surgery without tumor recurrence. The prognostic significance of ISCPs, particularly when they are the only pathologic finding in a testicular biopsy, is a matter of controversy. Based on the long normal evolution, we recommend a conservative approach to therapy. The bilateral and multicentric character of ISCPs and their association with Sertoli tumors and Peutz–Jeghers syndrome suggest that they represent either proliferative lesions with tumorigenic potential or the intraepithelial stage in the evolution of some testicular Sertoli cell tumors.
Multiple sclerosis and Alzheimer's disease

Chronic inflammation with microglia activation is thought to play a major role in the formation or clearance of Alzheimer's disease (AD) lesions, as well as in the induction of demyelination in multiple sclerosis (MS). In MS, the cortex is severely affected by chronic, long‐lasting inflammation, microglia activation, and demyelination. To what extent chronic inflammation in the cortex of MS patients influences the development of AD lesions is so far unresolved.
Deep Feature Fusion Network for Answer Quality Prediction in Community Question Answering

Community Question Answering (cQA) forums have become a popular medium for soliciting direct answers to specific questions of users from experts or other experienced users on a given topic. However, for a given question, users sometimes have to sift through a large number of low-quality or irrelevant answers to find out the answer which satisfies their information need. To alleviate this, the problem of Answer Quality Prediction (AQP) aims to predict the quality of an answer posted in response to a forum question. Current AQP systems either learn models using - a) various hand-crafted features (HCF) or b) use deep learning (DL) techniques which automatically learn the required feature representations. In this paper, we propose a novel approach for AQP known as - "Deep Feature Fusion Network (DFFN)" which leverages the advantages of both hand-crafted features and deep learning based systems. Given a question-answer pair along with its metadata, DFFN independently - a) learns deep features using a Convolutional Neural Network (CNN) and b) computes hand-crafted features using various external resources and then combines them using a deep neural network trained to predict the final answer quality. DFFN achieves state-of-the-art performance on the standard SemEval-2015 and SemEval-2016 benchmark datasets and outperforms baseline approaches which individually employ either HCF or DL based techniques alone.
The β-factor: measuring wireless link burstiness

Measuring 802.15. 4 reception in three testbeds, we find that most intermediate links are bursty: they shift between poor and good delivery. We present a metric to measure this link burstiness and name it β. We find that link burstiness affects protocol performance and that β can predict the effects. We show that measuring β allows us to reason about how long a protocol should pause after encountering a packet failure to reduce its transmission cost. We find that using β as a guide to setting a single constant in a standard sensor network data collection protocol reduces its average transmission cost by 15%. In addition to data from 802.15. 4 testbeds, we examine traces from 802.11b networks and find β has a broader relevance in the wireless domain.
Urban and Peri-Urban Agriculture in Developing Countries Studied using Remote Sensing and In Situ Methods

Urban farming, practiced by about 800 million people globally, has contributed significantly to food security and food safety. The practice has sustained livelihood of the urban and peri-urban low income dwellers in developing countries for many years. Its popularity among the urban low income is largely due to lack of formal jobs and as a means of adding up to household income. There is increasing need to sustainably manage urban farming in developing nations in recent times. Population increase due to rural-urban migration and natural, coupled with infrastructure developments are competing with urban farming for available space and scarce resources such as water for irrigation. Lack of reliable data on the extent of urban/peri-urban areas being used for farming has affected developing sustainable policies to manage urban farming in Accra. Using ground based survey methods to map the urban farmlands are inherently problematic and prohibitively expensive. This has influenced accurate assessment of the future role of urban farming in enhancing food security. Remote sensing, however, allows areas being used as urban farmlands to be rapidly established at relatively low cost. This paper will review advances in the use of remote sensing technology to develop an integrated monitoring technique for urban farmlands in Accra.
Evaluation of Total Antioxidant Capacity of Saliva in High School Students

Background and Objective: Imbalance between oxidative stress and saliva antioxidants plays a major role in initiation and spread of dental caries. The aim of this study was to evaluate the total antioxidant capacity (TAC) of saliva in dental caries. Methods: In this case-control study which employed high school students (14-18 years), the un-stimulated saliva samples of 60 students without dental caries (control group) and 60 students with dental caries (with at least 5 teeth levels of dental caries) were gathered. Each group comprised of males (half of cases) and females (half of cases). TAC of saliva was measured by Zellbio® (Netherlands) in terms of micmol/L. The data were analyzed using the SPSS software (ver. 17.0) and t-test with considering significance level at 0.05. Results: TAC of saliva was significantly lower in cases with dental caries (0.256±0.106) compared to those without dental caries (0.396±0.077); P< 0.001. There was no statistically significant difference of TAC of saliva between males (0.319±0.119) and females (0.333±0.113) irrespective of dental caries (P=0.507). Conclusion: The results of the study indicated that there was a reverse association between dental caries and TAC of saliva.
The pleiotropic ABNORMAL FLOWER AND DWARF1 affects plant height, floral development and grain yield in rice

Abstract Moderate plant height and successful establishment of reproductive organs play pivotal roles in rice grain production. The molecular mechanism that controls the two aspects remains unclear in rice. In the present study, we characterized a rice gene, ABNORMAL FLOWER AND DWARF1 (AFD1) that determined plant height, floral development and grain yield. The afd1 mutant showed variable defects including the dwarfism, long panicle, low seed setting and reduced grain yield. In addition, abnormal floral organs were also observed in the afd1 mutant including slender and thick hulls, and hull‐like lodicules. AFD1 encoded a DUF640 domain protein and was expressed in all tested tissues and organs. Subcellular localization showed AFD1‐green fluorescent fusion protein (GFP) was localized in the nucleus. Meantime, our results suggested that AFD1 regulated the expression of cell division and expansion related genes.
CFH Y402H polymorphism is associated with elevated vitreal GM-CSF and choroidal macrophages in the postmortem human eye

Purpose Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in people 50 years of age or older in developed countries. The homozygous CC genotype in the complement factor H (CFH) Y402H single nucleotide polymorphism (SNP; rs1061170) is widely recognized as a risk factor for the development of AMD. In this study, we examined vitreal levels of granulocyte macrophage colony-stimulating factor (GM-CSF), a hematopoietic cytokine, and macrophages in the choroid of postmortem human eyes genotyped for the CFH Y402H SNP. Methods Twenty-two pairs of postmortem, non-diseased, human donor eyes were obtained. The vitreous and retinal tissues of the left eyes were collected for GM-CSF level measurement and CFH Y402H genotyping, respectively. The right eyes were paraffin-embedded and sectioned for immunohistochemistry using a macrophage and microglia marker, CD68. Cell cultures of RPE cells were stimulated with complement C3a, C5a, 4-hydroxynonenal (HNE), or tumor necrosis factor alpha (TNF-α), and GM-CSF expression was measured with a suspension assay or quantitative PCR. Results Eyes genotyped with the CC or the CT risk variant of the CFH Y402H SNP showed significantly increased levels of GM-CSF in the vitreous compared to eyes with the protective TT variant (mean ± standard error of mean, 607.54±85.83 pg/ml or 656.32±15.20 pg/ml versus 286.69±81.96 pg/ml, p<0.05). The choroid of eye tissues genotyped with the CC variant showed higher levels of CD68 immunoreactivity than the tissues genotyped with the TT variant (p<0.05). The GM-CSF levels detected in the supernatant of RPE cells in culture treated with HNE or TNF-α were significantly higher compared to the non-treated control (145.88±5.06 pg/ml and 149.32±3.76 pg/ml versus 123.27±4.05 pg/ml, p<0.05). Furthermore, the gene expression of GM-CSF detected in the lysate of RPE cells stimulated with complement C3a or C5a showed significantly increased fold changes compared to the non-treated control (C3a: 2.38±0.31 fold, p<0.05; C5a: 2.84±0.54 fold, p<0.01). Conclusions Our data showed a relationship between the CFH Y402H polymorphism and GM-CSF levels in the vitreous and accumulation of choroidal macrophages in the postmortem eye. These data suggest that the at-risk variant of the CFH gene may contribute to the dysregulation of proinflammatory cytokines locally in the eye.
Prenatal Vitamin D and Dental Caries in Infants

OBJECTIVES: Inadequate maternal vitamin D (assessed by using 25-hydroxyvitamin D [25OHD]) levels during pregnancy may affect tooth calcification, predisposing enamel hypoplasia and early childhood caries (ECC). The purpose of this study was to determine the relationship between prenatal 25OHD concentrations and dental caries among offspring during the first year of life. METHODS: This prospective cohort study recruited expectant mothers from an economically disadvantaged urban area. A prenatal questionnaire was completed and serum sample drawn for 25OHD. Dental examinations were completed at 1 year of age while the parent/caregiver completed a questionnaire. The examiner was blinded to mothers’ 25OHD levels. A P value ≤ . 05 was considered significant. RESULTS: Overall, 207 women were enrolled (mean age: 19 ± 5 years). The mean 25OHD level was 48 ± 24 nmol/L, and 33% had deficient levels. Enamel hypoplasia was identified in 22% of infants; 23% had cavitated ECC, and 36% had ECC when white spot lesions were included in the assessment. Mothers of children with ECC had significantly lower 25OHD levels than those whose children were caries-free (41 ± 20 vs 52 ± 27 nmol/L; P = .05). Univariate Poisson regression analysis for the amount of untreated decay revealed an inverse relationship with maternal 25OHD. Logistic regression revealed that enamel hypoplasia (P < .001), infant age (P = .002), and lower prenatal 25OHD levels (P = .02) were significantly associated with ECC. CONCLUSIONS: This study found that maternal prenatal 25OHD levels may have an influence on the primary dentition and the development of ECC.
Understanding White Collar Crime

This comprehensive overview of white collar crime begins by introducing the concept, looking at its definition, its identification with class and status, and its development within criminology. The problems of estimating the vast extent of white collar and corporate crime are explored, and some of its major forms are outlined, including fraud, corruption, employment, consumer and environmental crime.
Human heme oxygenase‐1 deficiency: A lesson on serendipity in the discovery of the novel disease

The first case of human heme oxygenase (HO)‐1 deficiency was reported by Yachie et al. at our laboratory in the Department of Pediatrics, Angiogenesis and Vascular Development, Kanazawa University Graduate School of Medical Science, in 1999. In the present paper I would like to review this novel disease. Our studies into HO‐1 deficiency were called by us ‘Kanazawa version Project X’. From the story of our successful discovery we have learned that serendipity is a very important spiritual factor. Serendipity is the making of fortunate and unexpected discoveries by chance (from its possession by the heroes in the Persian fairy tale The Three Princes of Serendip).
Purification of the viridicin produced by Aerococcus viridans

A new bacteriocin produced by Aerococcus viridans was purified. Bacteria grown on liquid medium synthesized a bacteriocin, viridicin, which can be extracted from the cells by treatment with 0.86 M NaCl solution. Viridicin production was not induced by ultraviolet irradiation or by treatment with mitomycin C. The bacteriocin was purified by ultrafiltration, gel filtration, and preparative polyacrylamide disc gel electrophoresis. The molecular weight was between 100,000 and 120,000. The purified viridicin was homogeneous on polyacrylamide gel electrophoresis. The viridicin was composed of protein, carbohydrate, and lipid.
A Unified Framework for Dynamic Prediction Market Design

Recently, coinciding with and perhaps driving the increased popularity of prediction markets, several novel pari-mutuel mechanisms have been developed such as the logarithmic market-scoring rule (LMSR), the cost-function formulation of market makers, utility-based markets, and the sequential convex pari-mutuel mechanism (SCPM). In this work, we present a convex optimization framework that unifies these seemingly unrelated models for centrally organizing contingent claims markets. The existing mechanisms can be expressed in our unified framework by varying the choice of a concave value function. We show that this framework is equivalent to a convex risk minimization model for the market maker. This facilitates a better understanding of the risk attitudes adopted by various mechanisms. The unified framework also leads to easy implementation because we can now find the cost function of a market maker in polynomial time by solving a simple convex optimization problem. In addition to unifying and explaining the existing mechanisms, we use the generalized framework to derive necessary and sufficient conditions for many desirable properties of a prediction market mechanism such as proper scoring, truthful bidding (in a myopic sense), efficient computation, controllable risk measure, and guarantees on the worst-case loss. As a result, we develop the first proper, truthful, risk-controlled, loss-bounded (independent of the number of states) mechanism; none of the previously proposed mechanisms possessed all these properties simultaneously. Thus, our work provides an effective tool for designing new prediction market mechanisms. We also discuss possible applications of our framework to dynamic resource pricing and allocation in general trading markets.
The Influence of Ectopic Migration of Granule Cells into the Hilus on Dentate Gyrus-CA3 Function

Postnatal neurogenesis of granule cells (GCs) in the dentate gyrus (DG) produces GCs that normally migrate from the subgranular zone to the GC layer. However, GCs can mismigrate into the hilus, the opposite direction. Previous descriptions of these hilar ectopic GCs (hEGCs) suggest that they are rare unless there are severe seizures. However, it is not clear if severe seizures are required, and it also is unclear if severe seizures are responsible for the abnormalities of hEGCs, which include atypical dendrites and electrophysiological properties. Here we show that large numbers of hEGCs develop in a transgenic mouse without severe seizures. The mice have a deletion of BAX, which normally regulates apoptosis. Surprisingly, we show that hEGCs in the BAX-/- mouse have similar abnormalities as hEGCs that arise after severe seizures. We next asked if there are selective effects of hEGCs, i.e., whether a robust population of hEGCs would have any effect on the DG if they were induced without severe seizures. Indeed, this appears to be true, because it has been reported that BAX-/- mice have defects in a behavior that tests pattern separation, which depends on the DG. However, inferring functional effects of hEGCs is difficult in mice with a constitutive BAX deletion because there is decreased apoptosis in and outside the DG. Therefore, a computational model of the normal DG and hippocampal subfield CA3 was used. Adding a small population of hEGCs (5% of all GCs), with characteristics defined empirically, was sufficient to disrupt a simulation of pattern separation and completion. Modeling results also showed that effects of hEGCs were due primarily to “backprojections” of CA3 pyramidal cell axons to the hilus. The results suggest that hEGCs can develop for diverse reasons, do not depend on severe seizures, and a small population of hEGCs may impair DG-dependent function.