Miracle-dz/UniFAR-FTUs huggingface dataset:
AtPDCD5 plays a role during dark-senescence in Arabidopsis

ABSTRACT In this work, we investigated the role of an Arabidopsis protein, AtPDCD5, during senescence after a 24h-dark period. Previously, we demonstrated that AtPDCD5 participates in programmed cell death (PCD) after UV-B exposure and in age-induced senescence. The results presented here, together with previous data, demonstrate that AtPDCD5 not only plays an important role during DNA damage responses induced by UV-B radiation, but also takes part in PCD programs such as dark-induced senescence in Arabidopsis.
AKAP-Mediated Targeting of Protein Kinase A Regulates Contractility in Cardiac Myocytes

Abstract— Compartmentalization of cAMP-dependent protein kinase A (PKA) by A-kinase anchoring proteins (AKAPs) targets PKA to distinct subcellular locations in many cell types. However, the question of whether AKAP-mediated PKA anchoring in the heart regulates cardiac contractile function has not been addressed. We disrupted AKAP-mediated PKA anchoring in cardiac myocytes by introducing, via adenovirus-mediated gene transfer, Ht31, a peptide that binds the PKA regulatory subunit type II (RII) with high affinity. This peptide competes with endogenous AKAPs for RII binding. Ht31P (a proline-substituted derivative), which does not bind RII, was used as a negative control. We then investigated the effects of Ht31 expression on RII distribution, Ca2+ cycling, cell shortening, and PKA-dependent substrate phosphorylation. By confocal microscopy, we showed redistribution of RII from the perinuclear region and from periodic transverse striations in Ht31P-expressing cells to a diffuse cytosolic localization in Ht31-expressing cells. In the presence of 10 nmol/L isoproterenol, Ht31-expressing myocytes displayed an increased rate and amplitude of cell shortening and relaxation compared with control cells (uninfected and Ht31P-expressing myocytes); with isoproterenol stimulation we observed decreased time to 90% decline in Ca2+ but no significant difference between Ht31-expressing and control cells in the rate of Ca2+ cycling or amplitude of the Ca2+ transient. The increase in PKA-dependent phosphorylation of troponin I and myosin binding protein C on isoproterenol stimulation was significantly reduced in Ht31-expressing cells compared with controls. Our results demonstrate that, in response to &bgr;-adrenergic stimulation, cardiomyocyte function and substrate phosphorylation by PKA is regulated by targeting of PKA by AKAPs.
Macrophages, Foreign Body Giant Cells and Their Response to Implantable Biomaterials

All biomaterials, when implanted in vivo, elicit cellular and tissue responses. These responses include the inflammatory and wound healing responses, foreign body reactions, and fibrous encapsulation of the implanted materials. Macrophages are myeloid immune cells that are tactically situated throughout the tissues, where they ingest and degrade dead cells and foreign materials in addition to orchestrating inflammatory processes. Macrophages and their fused morphologic variants, the multinucleated giant cells, which include the foreign body giant cells (FBGCs) are the dominant early responders to biomaterial implantation and remain at biomaterial-tissue interfaces for the lifetime of the device. An essential aspect of macrophage function in the body is to mediate degradation of bio-resorbable materials including bone through extracellular degradation and phagocytosis. Biomaterial surface properties play a crucial role in modulating the foreign body reaction in the first couple of weeks following implantation. The foreign body reaction may impact biocompatibility of implantation devices and may considerably impact short- and long-term success in tissue engineering and regenerative medicine, necessitating a clear understanding of the foreign body reaction to different implantation materials. The focus of this review article is on the interactions of macrophages and foreign body giant cells with biomaterial surfaces, and the physical, chemical and morphological characteristics of biomaterial surfaces that play a role in regulating the foreign body response. Events in the foreign body response include protein adsorption, adhesion of monocytes/macrophages, fusion to form FBGCs, and the consequent modification of the biomaterial surface. The effect of physico-chemical cues on macrophages is not well known and there is a complex interplay between biomaterial properties and those that result from interactions with the local environment. By having a better understanding of the role of macrophages in the tissue healing processes, especially in events that follow biomaterial implantation, we can design novel biomaterials-based tissue-engineered constructs that elicit a favorable immune response upon implantation and perform for their intended applications.
Exploring the linkage between the home domain and absence from work: Health, motivation, or both?

The aim of this study was twofold. First, we examined depleting and enriching effects of employees' home domain (home demands and quality time spent at home) on unscheduled absence from work. Second, we tested the assumption of the medical and withdrawal models that absence duration and frequency are uniquely predicted by respectively health condition and job motivation. We used longitudinal, different-source data from 1014 employees. The results showed that home quality time was negatively related to absence frequency and duration in the following year through a physical pathway (less physical stress symptoms and health complaints) and through a psychological pathway (less psychological stress symptoms, increased job motivation). Employees with heavy home demands reported more physical and psychological stress symptoms, more health complaints, and lower job motivation. Accordingly, they had longer and more frequent sick leaves in the consecutive year. We conclude that the home domain adds to our understanding of absence from work. In addition, the model including cross pathways between health complaints and job motivation on the one hand, and absence frequency and duration on the other, best fitted the data. Thus, a clear distinction between volitional absence (frequency) and absence due to illness (duration) seems hard to justify
Effect of brain‐derived neurotrophic factor haploinsufficiency on stress‐induced remodeling of hippocampal neurons

Chronic restraint stress (CRS) induces the remodeling (i.e., retraction and simplification) of the apical dendrites of hippocampal CA3 pyramidal neurons in rats, suggesting that intrahippocampal connectivity can be affected by a prolonged stressful challenge. Since the structural maintenance of neuronal dendritic arborizations and synaptic connectivity requires neurotrophic support, we investigated the potential role of brain derived neurotrophic factor (BDNF), a neurotrophin enriched in the hippocampus and released from neurons in an activity‐dependent manner, as a mediator of the stress‐induced dendritic remodeling. The analysis of Golgi‐impregnated hippocampal sections revealed that wild type (WT) C57BL/6 male mice showed a similar CA3 apical dendritic remodeling in response to three weeks of CRS to that previously described for rats. Haploinsufficient BDNF mice (BDNF±) did not show such remodeling, but, even without CRS, they presented shorter and simplified CA3 apical dendritic arbors, like those observed in stressed WT mice. Furthermore, unstressed BDNF± mice showed a significant decrease in total hippocampal volume. The dendritic arborization of CA1 pyramidal neurons was not affected by CRS or genotype. However, only in WT mice, CRS induced changes in the density of dendritic spine shape subtypes in both CA1 and CA3 apical dendrites. These results suggest a complex role of BDNF in maintaining the dendritic and spine morphology of hippocampal neurons and the associated volume of the hippocampal formation. The inability of CRS to modify the dendritic structure of CA3 pyramidal neurons in BDNF± mice suggests an indirect, perhaps permissive, role of BDNF in mediating hippocampal dendritic remodeling. © 2010 Wiley‐Liss, Inc.
Comparing quality of life using the World Health Organization Quality of Life measure (WHOQOL-100) in a clinical and non-clinical sample: Exploring the role of self-esteem, self-efficacy and social functioning

Background: Quality of life assessments provide a measure of client-assessed wellbeing and help clinicians recognize issues of importance to clients. Comparing quality of life in individuals with a mental illness and individuals without mental illness would allow us to profile and understand the needs of individuals with mental illness understand the impact of stigma and narrow the treatment gap. Aims: To compare quality of life in individuals with severe mental illness against a sample of the general population and to investigate the role of self-esteem, self-efficacy and social functioning. Method: The World Health Organization Quality of Life measure (WHOQOL-100) along with the Rosenberg Self-Esteem Scale (RSE) and the Generalized Self Efficacy Scale (GSES) were administered to 104 individuals, 52 of whom were mental health service users with the remaining 52 participants sampled from the general population. Results: Significant differences were found between clinical and non-clinical groups in four domains of the WHOQOL-100 and in a majority of the facets within domains. Two domains, Level of Independence and Social Relationships, were important differentiating aspects of QoL between the clinical and non-clinical sample as the highest significant differences were recorded there (t = 12.150, p < 0.001 and t = 7.252, p < 0.001 respectively). Lower self-esteem and self-efficacy scores were recorded for the clinical sample compared to the non-clinical sample. Conclusions: The negative repercussions of mental illness encompassed almost all aspects of QoL that individuals had ascertained to be important for satisfaction and wellbeing in everyday life. Findings also indicated that individuals with mental illness have similar needs to a “normal” population in terms of social support and social networks and that inter-personal issues were probably more pervasive than intra-psychic events with regard to QoL. We conclude that the concept of QoL offers clinicians an increased awareness and greater concern for life issues for people who are mentally ill, helping us to develop collaborative relationships and provide effective interventions for individuals with mental illness. Declaration of interest: None.
Pengaruh Akuntansi Forensik dan Audit Investigasi terhadap Pengungkapan Fraud (Studi Kasus pada Badan Pengawasan Keuangan dan Pembangunan (BPKP) Perwakilan Jawa Barat)

Tujuan dari penelitian ini adalah untuk mengetahui pengaruh akuntansi forensik serta audit investigasi yang dimiliki auditor terhadap pengungkapan fraud . Penelitian ini dilakukan di Badan Pengawasan Keuangan dan Pembangunan (BPKP) Perwakilan Jawa Barat. Penelitian ini menggunakan metode penelitian deskriptif kuantitatif. Pengumpulan data pada penelitian ini menggunakan kuesioner dengan sampel auditor investigasi di Badan Pengawasan Keuangan dan Pembangunan (BPKP) Perwakilan Jawa Barat sebanyak 32 responden. Teknik analisis data yang digunakan adalah analisis regresi linier berganda dengan bantuan alat analisis data SPSS ( Statistical Product and Service Solutions ). Hasil penelitian ini menunjukkan bahwa akuntansi forensik serta audit investigas berpengaruh sangat baik secara parsial maupun simultan terhadap pengungkapan fraud . Berdasarkan hasil analisis, hubungan yang kuat juga ditunjukkan kedua variable bebas terhadap pengungkapan fraud 0.647 (R), selain itu kemampuan yang ditunjukkan variabel-variabel independen dalam menjelaskan pengungkapan fraud adalah sebesar45,5% (R square = 0.455) sedangkan 54,5% dipengaruhi oleh variabel lain di luar penelitian ini.
Genetic algorithms for job shop scheduling problems with alternative routings

The purpose of this research is to solve a general job shop problem with alternative machine routings. We consider four performance measures: mean flow time, makespan, maximum lateness, and total absolute deviation from the due dates. We first develop mixed-integer linear programming (MILP) formulations for the problems. The MILP formulations can be used either to compute optimal solutions for small-sized problems or to test the performance of existing heuristic algorithms. In addition, we have developed a genetic algorithm that can be used to generate relatively good solutions quickly. Further, computational experiments have been performed to compare the solution of the MILP formulations with that of existing algorithms.
Do you hear it now? A native advantage for sarcasm processing*

Context and prosody are the main cues native-English speakers rely on to detect and interpret sarcastic irony within spoken discourse. The importance of each type of cue for detecting sarcasm has not been fully investigated in native speakers and has not been examined at all in adult English learners. Here, we compare the extent to which native-English speakers and Arabic-speaking English learners rely on contextual and prosodic cues to identify sarcasm in spoken English, situating these findings within current cross-linguistic effects literature. We show Arabic speakers utilize the cues to a different extent than native speakers: they tend not to utilize prosodic information, focusing on contextual semantic information. These results help clarify the relative weight of contextual and prosodic cues in native-English speakers and support theories that suggest that prosody and emotion could transfer separately in second language learning such that one could transfer while the other does not.
Modern europe

Class Description A survey of Europe from 1789 to the present. Investigates the political, social, economic, and cultural developments that shaped and continue to shape the modern age. Emphasis is on the evolution of the nation-state, on industrialization and its impact on society and politics, and on the intellectual responses to the rapid changes these developments inspired. Topics include Europe and the French Revolution; the rise of the nation-state, 1848-1914; and the impact of totalitarian ideologies on 20th-century Europe.
Environmental Influences on Preschoolers' Physical Activity Levels in Various Early-Learning Facilities

Purpose: This study aimed to: (a) compare the physical activity (PA) levels (i.e., moderate-to-vigorous PA [MVPA] and total PA [TPA]) of preschoolers in 3 different early-learning environments (center-based childcare, home-based childcare, and full-day kindergarten [FDK]); and (b) assess which characteristics (e.g., play equipment, policies, etc.) of these settings influenced preschoolers' PA. Method: Twenty-seven facilities (9 centers, 10 homes, and 8 FDK) participated in this study. Participants (aged 2.5–5 years; n = 297) were fitted with Actical™ accelerometers for 5 consecutive days during childcare/school hours to assess their PA. The Environment and Policy Assessment and Observation (EPAO) tool was used to objectively examine the PA environment of all participating facilities. Finally, demographic questionnaires were administered to preschoolers' parents/guardians. Results: Preschoolers in FDK accumulated significantly more MVPA (p < .05; 3.33 min/hr) than those in center- (1.58 min/hr) and home-based (1.75 min/hr) childcare, and they accumulated significantly more TPA (p < .05; 20.31 min/hr) than those in center-based childcare (18.36 min/hr). For FDK, the Active Opportunities, Sedentary Opportunities, Sedentary Environment, and Fixed Play Environment subscales of the EPAO significantly impacted both MVPA and TPA. For center-based childcare, only the Sedentary Environment subscale was found to impact MVPA and TPA. No subscales influenced children's MVPA or TPA in home-based childcare. Conclusions: This research underscores the need to encourage/support preschoolers' active behaviors in early-learning settings, particularly for those in center- and home-based childcare. Furthermore, this article highlights environmental and staff characteristics on which future PA programming should focus.
Comparing Futures or Comparing Pasts?

This article, firstly and briefly, suggests that there is no single or unified 'comparative education' but that there are multiple comparative educations. How may such a variety of comparative educations be distinguished? Rather more importantly and secondly, what might an 'interesting' comparative education constructed in universities look like, and on what criteria would it be interesting? The specific suggestion offered here is that at least one kind of comparative education, for a decade or so, should concentrate on exploring moments of educational metamorphosis, rather than assuming that the equilibrium conditions and the dynamic linearities of development of educational systems can be predicted. Thus for the moment the correct answer to the question, how far can we learn anything of practical value from the study of foreign educational systems is: 'not a lot'. The correct question is, why have we as scholars taken that question so seriously for so long?
The Fiscal Theory of the Price Level

The Fiscal Theory of the Price Level (FTPL) has led to lively academic discussion over the last few years. Supporters claim that the theory challenges the conventional view that inflation is always and everywhere a monetary phenomenon, and the corresponding policy view that an independent central bank powerful enough to impose the seigniorage time path is sufficient to guarantee price stability. The theory has also been presented as providing a potential rationale for the imposition of fiscal restrictions in monetary unions, where incentives for fiscal free-riding are higher than in a single-country setting. Critics, on the other hand, claim that the theory lacks empirical relevance or, taking an extreme view, that it is simply a fallacy. This paper briefly discusses the main implications and controversial aspects of the FTPL, taking as a benchmark the classical unpleasant arithmetic framework of Sargent and Wallace (1981). Fernando Ballabriga. <fernando.ballabriga@esade.edu> 1 I would like to thank J. Kröeger, W. Schuele and W. Röger for their useful comments and discussions.
Stellar evolution with rotation - XIII. Predicted GRB rates at various Z

We present the evolution of rotation in models of massive single stars covering a wide range of masses and metallicities. These models reproduce observations during the early stages of the evolution very well, in particular Wolf-Rayet (WR) populations and ratio between type II and type Ib,c supernovae at different metallicities. Our models predict the production of fast-rotating black holes. Models with large initial masses or high metallicity end their lives with less angular momentum in their central remnant with respect to the break-up limit for the remnant. Many WR star models satisfy the three main criteria (black hole formation, loss of hydrogen-rich envelope, and enough angular momentum to form an accretion disk around the black hole) for gamma-ray bursts (GRB) production via Woosley's collapsar model. If we consider all types of WR stars as GRB progenitors, there would be too many GRBs compared to observations but if we consider only WO stars (type Ic supernovae as is the case for SN2003dh/GRB030329) as GRB progenitors, the GRB production rates are in much better agreement with observations. WO stars are produced only at low metallicities in the present series of models. This prediction can be tested by future observations.
Examining Strengths and Challenges of Rapid Rural Immigration

Intensive, in-depth interviews were conducted with 45 non-Hispanic white residents of three rural Nebraska meatpacking com­ munities. The purpose of the investigation was to document (I) percep­ tions of community change; (2) community-wide benefits of a new Latino population; and (3) strategies for strengthening multi-ethnic rural communities. Data were analyzed using Thematic Analyses (Aronson 1994). Application of the findings, for strengthening rural communities, is discussed.
Designing a machine learning potential for molecular simulation of liquid alkanes

First-year training funded by the EPSRC as part of the centre for doctoral training in computational methods for materials science (CDT CMM) under grant number EP/L015552/1. PhD studentship funding by Shell Global Solutions International B.V. Computer time provided by ARCHER (http://archer.ac.uk) under the UKCP Consortium, EPSRC grant number EP/P022596/1.
THE RELATIONSHIP BETWEEN PARENTAL STYLE AND EMOTIONAL INTELLIGENCE AMONG STUDENTS OF PAYAME NOOR UNIVERSITY

This study examines the relationship between parental style and emotional intelligence among students of Payaeme Noor University on 2011 in Iran. This study is a descriptive one and type of causal-comparison. Sample size is 75 patients (28 men and 47 women) and used simple random sampling. The data collected by Shaffer’s Parental Styles of Questionnaire (1991) and Emotional Intelligence Scale (EIS; Syberyashring, 1986). Results showed that the level of emotional intelligence of students based on their parental styles is different. One-way analysis of variance showed that the mean emotional intelligence scores of children are different based on parental style and Tokay’s test showed that there was a significant difference between emotional intelligence of students with Authoritative parental and neglectful parental. Also the results showed that there was no significant difference between male and female students' in emotional intelligence. Field of Research: Emotional intelligence, Parental style, University students.
Moderators of Negative Peer Influence on Early Adolescent Externalizing Behaviors

This study examined the extent to which antisocial behavior, parenting, and school connectedness moderated the association between peer deviancy in preadolescence and externalizing problems in early adolescence. The participants included 500 boys and girls, most of them African Americans. Peer deviancy was measured with teacher reports of aggressive-disruptive behavior for classmates identified by target children as friends. Parents provided information on parenting practices (nurturance and harsh and inconsistent discipline) and children's antisocial behavior. Children reported on their school connectedness and externalizing behaviors (delinquency and substance use) in preadolescence and early adolescence. Externalizing problems in early adolescence were associated with preadolescent externalizing and antisocial behavior and older age. Peer deviancy predicted externalizing problems only when combined with higher levels of antisocial behavior and negative parenting. School connectedness, gender, and ethnicity did not moderate the link between peer deviancy and externalizing problems.