Miracle-dz/UniFAR-FTUs huggingface dataset:
Correlation between 99Tcm-HMPAO-SPECT brain image and a history of decompression illness or extent of diving experience in commercial divers.

OBJECTIVES: To explore the use of 99technetiumm-hexamethyl propylene amine oxime single photon computed tomography (HMPAO-SPECT) of the brain as a means of detecting nervous tissue damage in divers and to determine if there is any correlation between brain image and a diver's history of diving or decompression illness (DCI). METHODS: 28 commercial divers with a history of DCI, 26 divers with no history of DCI, and 19 non-diving controls were examined with brain HMPAO-SPECT. Results were classified by observer assessment as normal (I) or as a pattern variants (II-V). The brain images of a subgroup of these divers (n = 44) and the controls (n = 17) were further analysed with a first order texture analysis technique based on a grey level histogram. RESULTS: 15 of 54 commercial divers (28%) were visually assessed as having HMPAO-SPECT images outside normal limits compared with 15.8% in appropriately identified non-diver control subjects. 18% of divers with a history of DCI were classified as having a pattern different from the normal image compared with 38% with no history of DCI. No association was established between the presence of a pattern variant from the normal image and history of DCI, diving, or other previous possible neurological insult. On texture analysis of the brain images, divers had a significantly lower mean grey level (MGL) than non-divers. Divers with a history of DCI (n = 22) had a significantly lower MGL when compared with divers with no history of DCI (n = 22). Divers with > 14 years professional diving or > 100 decompression days a year had a significantly lower MGL value. CONCLUSIONS: Observer assessment of HMPAO-SPECT brain images can lead to disparity in results. Texture analysis of the brain images supplies both an objective and consistent method of measurement. A significant correlation was found between a low measure of MGL and a history of DCI. There was also an indication that diving itself had an effect on texture measurement, implying that it had caused subclinical nervous tissue damage.
Diversity predicts stability and resource use efficiency in natural phytoplankton communities

The relationship between species diversity and ecosystem functioning has been debated for decades, especially in relation to the “macroscopic” realm (higher plants and metazoans). Although there is emerging consensus that diversity enhances productivity and stability in communities of higher organisms; however, we still do not know whether these relationships apply also for communities of unicellular organisms, such as phytoplankton, which contribute ≈50% to the global primary production. We show here that phytoplankton resource use, and thus carbon fixation, is directly linked to the diversity of phytoplankton communities. Datasets from freshwater and brackish habitats show that diversity is the best predictor for resource use efficiency of phytoplankton communities across considerable environmental gradients. Furthermore, we show that the diversity requirement for stable ecosystem functioning scales with the nutrient level (total phosphorus), as evidenced by the opposing effects of diversity (negative) and resource level (positive) on the variability of both resource use and community composition. Our analyses of large-scale observational data are consistent with experimental and model studies demonstrating causal effects of microbial diversity on functional properties at the system level. Our findings point at potential linkages between eutrophication and pollution-mediated loss of phytoplankton diversity. Factors reducing phytoplankton diversity may have direct detrimental effects on the amount and predictability of aquatic primary production.
Wedding cultural heritage and sustainable development: three years after

Purpose – This paper is an editorial to JCHMSD's Volume 4, Issue 1 and its selection of papers. The purpose of this paper is to reflect upon the first three years of editorship, reporting a critical self-assessment on the progress achieved today in relation to JCHMSD's initial aims and objectives, embedded in the state-of-the-art. Design/methodology/approach – The paper builds upon editorship observations exchanged among the editorial team over the last three years and a literature review on the 42 papers published in JCHMSD. The literature review focuses primarily on: purposes and design/methodology/approaches. The ways forward sets a research agenda, challenging those contributing to the unexplored questions with their research and/or practices, to join the JCHMSD community and enable a broader audience to, at least, learn from them. Findings – JCHMSD's three aims have been achieved. The journal is publishing innovative research and practices, relating cultural heritage management and sustainable develo.
Real‐time observation of transplanted ‘green germ cells’: Proliferation and differentiation of stem cells

To elucidate the mechanism of proliferation and differentiation of testicular germ cells, donor testicular germ cells labeled with enhanced green fluorescent protein (eGFP) were transplanted to recipient seminiferous tubules. The kinetics of colonization as well as of differentiation of the donor cells was followed in the same transplanted tubules (alive) under ultraviolet light. One week after transplantation, clusters of fluorescent cells were randomly spread as dots in the recipient seminiferous tubule, whereas non‐homed cells flowed out from the testis to the epididymis. By 4 weeks after transplantation, green germ cells were observed with weak and moderate fluorescence along the recipient seminiferous tubule. By 8 weeks, proliferation and differentiation of the germ cells occurred, resulting in strong fluorescence in the middle part of the seminiferous tubule but in weak and moderate fluorescence at both terminals. The length of the fluorescent positive seminiferous tubule became longer. Detailed histological analyses of the recipient tubules indicated that the portions of the seminiferous tubule in weak, moderate, and strong fluorescence contained the spermatogonia, spermatogonia with spermatocytes, and all types of germ cells including spermatids, respectively. Thus, testicular stem cells colonized first as dots within 1 week, and then proliferated along the basement membrane of the seminiferous tubules followed by differentiation.
Improving children’s formal word definitions: A feasibility study

The ability to define a word with accuracy and precision is an important skill that has been associated with academic achievement. This study investigated the feasibility of conducting a lesson on formal word definitions to improve children’s definitional production. The participants were 18 children in grade 4 (mean age: 9 years; 8 months) who were delayed readers by one grade level. Initially, the children wrote definitions for high- and lower-frequency nouns and verbs. Subsequently, a definitional lesson was delivered, which focused on the formal structure of noun and verb definitions and accuracy/precision of meaning. Lastly, the children were given a written post-test, which also contained high- and lower-frequency nouns and verbs. Words were controlled for frequency, imageability, difficulty, and familiarity. Noun and verb definitions were coded and scored for level of structure (form). Nouns were coded and scored for content (expressed meaning). Results indicated that post-test scores were significantly higher for form for nouns and verbs. For content, noun scores were significantly higher in post-test. Findings indicated that a one-time lesson on formal definitional production can positively influence children’s definitions. Limitations of the study and future research ideas are discussed.
Semantic Networks: Structure and Dynamics

During the last ten years several studies have appeared regarding language complexity. Research on this issue began soon after the burst of a new movement of interest and research in the study of complex networks, i.e., networks whose structure is irregular, complex and dynamically evolving in time. In the first years, network approach to language mostly focused on a very abstract and general overview of language complexity, and few of them studied how this complexity is actually embodied in humans or how it affects cognition. However research has slowly shifted from the language-oriented towards a more cognitive-oriented point of view. This review first offers a brief summary on the methodological and formal foundations of complex networks, then it attempts a general vision of research activity on language from a complex networks perspective, and specially highlights those efforts with cognitive-inspired aim.
Competitive Hebbian learning and the hippocampal place cell system: Modeling the interaction of visual and path integration cues

The hippocampus has long been thought essential for implementing a cognitive map of the environment. However, almost 30 years since place cells were found in rodent hippocampal field CA1, it is still unclear how such an allocentric representation arises from an egocentrically perceived world. By means of a competitive Hebbian learning rule responsible for coding visual and path integration cues, our model is able to explain the diversity of place cell responses observed in a large set of electrophysiological experiments with a single fixed set of parameters. Experiments included changes observed in place fields due to exploration of a new environment, darkness, retrosplenial cortex inactivation, and removal, rotation, and permutation of landmarks. To code for visual cues for each landmark, we defined two perceptual schemas representing landmark bearing and distance information over a linear array of cells. The information conveyed by the perceptual schemas is further processed through a network of adaptive layers which ultimately modulate the resulting activity of our simulated place cells. In path integration terms, our system is able to dynamically remap a bump of activity coding for the displacement of the animal in relation to an environmental anchor. We hypothesize that path integration information is computed in the rodent posterior parietal cortex and conveyed to the hippocampus where, together with visual information, it modulates place cell activity. The resulting network yields a more direct treatment of partial remapping of place fields than other models. In so doing, it makes new predictions regarding the nature of the interaction between visual and path integration cues during new learning and when the system is challenged with environmental changes. Hippocampus 2001;11:216–239. © 2001 Wiley‐Liss, Inc.
Multiple Perspectives Within the Family

The first aim of the present study was to examine the extent to which the larger network of family relationships (parent-adolescent, marital, and sibling relations) affect adolescent adjustment. The second aim was to identify distinct patterns of family relationships and to examine whether these different family relationship patterns are associated with adolescent adjustment. The sample consisted of 288 intact families with two adolescent siblings. Each family member provided information on the affective quality of his or her relationship with every other family member (round-robin design). The quality of all family relations was related to the indicators of deviant development (problem behavior) but not to the indicators of normative development (identity formation). Five distinct and theoretically consistent clusters of different constellations of affective family relations were found. Differences in adolescent problem behavior were related to the cluster membership. The usefulness of the family systems perspective for research on adolescent development is discussed.
Twentieth anniversary of Homo antecessor (1997‐2017): a review

It has been twenty years since diagnosis and publication of the species Homo antecessor.1 Since then, new human fossils recovered from the TD6 level of the Gran Dolina site (Sierra de Atapuerca, northern Spain) have helped to refine its taxonomic and phylogenetic position. In this paper, we present a synthesis of the most characteristic features of this species, as well as our interpretation derived from the latest investigations. We focus on the phylogenetic interpretation of Homo antecessor, taking into account the most recent paleogenetic analyses and a reassessment of the European Middle Pleistocene hominin record. We try to show that, twenty years after its publication, H. antecessor provides a good opportunity to address the morphology of the last common ancestor of Neandertals and modern humans.
Taking the conservative Protestant thesis across the Atlantic: a comparative analysis of the relationships between violence, religion, and stimulants use in rural Netherlands

Building upon the Southern culture of violence research tradition, this article inquires the association between rural violence and Conservative Protestantism in the Dutch context. Based on data of 8,106 individuals, it was found that young rural Conservative Protestants living in villages were more likely to report that they had committed violence, as compared to their fellow believers living in urbanized areas. Furthermore, it turned out that the association between alcohol consumption and violence is stronger among this category of religious rural youth. Finally, this study demonstrates that, contrary to the prevailing notion of the idyllic rural, the violence rates between young Dutch rural dwellers and their peers living in the rest of the country are virtually similar.
Contribution of Trans-Fatty Acid Intake to Coronary Heart Disease Burden in Australia: A Modelling Study

Trans-fatty acids (TFAs) intake has been consistently associated with a higher risk of coronary heart disease (CHD) mortality. We provided an updated assessment of TFA intake in Australian adults in 2010 and conducted modeling to estimate CHD mortality attributable to TFA intake. Data of the 2011–2012 National Nutrition and Physical Activity Survey was used to assess TFA intake. The CHD burden attributable to TFA was calculated by comparing the current level of TFA intake to a counterfactual setting where consumption was lowered to a theoretical minimum distribution of 0.5% energy. The average TFA intake among adults was 0.59% energy, and overall 10% of adults exceeded the World Health Organization (WHO) recommended limit of 1% energy. Education and income were moderately and inversely associated with TFA intake (p-value ≤ 0.001), with one in seven adults in the lowest income and education quintile having >1% energy from TFA. Australia had 487 CHD deaths (95% uncertainty interval, 367–615) due to TFA exposure, equivalent to 1.52% (95% uncertainty limits: 1.15%–1.92%) of all CHD mortality. The relative impact of TFA exposure on CHD mortality in Australia is limited, but, in absolute terms, still substantial. Policies aimed at reducing industrial TFA exposure can reduce socioeconomic inequalities in health and may therefore be desirable.
Ascophyllan Purified from Ascophyllum nodosum Induces Th1 and Tc1 Immune Responses by Promoting Dendritic Cell Maturation

Marine-derived sulfated polysaccharides have been shown to possess certain anti-virus, anti-tumor, anti-inflammatory and anti-coagulant activities. However, the in vivo immunomodulatory effects of marine-derived pure compounds have been less well characterized. In this study, we investigated the effect of ascophyllan, a sulfated polysaccharide purified from Ascophyllum nodosum, on the maturation of mouse dendritic cells (DCs) in vitro and in vivo. Ascophyllan induced up-regulation of co-stimulatory molecules and production of pro-inflammatory cytokines in bone marrow-derived DCs (BMDCs). Moreover, in vivo administration of ascophyllan promotes up-regulation of CD40, CD80, CD86, MHC class I and MHC class II and production of IL-6, IL-12 and TNF-α in spleen cDCs. Interestingly, ascophyllan induced a higher degree of co-stimulatory molecule up-regulation and pro-inflammatory cytokine production than fucoidan, a marine-derived polysaccharide with well-defined effect for promoting DC maturation. Ascophyllan also promoted the generation of IFN-γ-producing Th1 and Tc1 cells in the presence of DCs in an IL-12-dependent manner. Finally, myeloid differentiation primary response 88 (MyD88) signaling pathway was essential for DC maturation induced by ascophyllan. Taken together, these results demonstrate that ascophyllan induces DC maturation, and consequently enhances Th1 and Tc1 responses in vivo. This knowledge could facilitate the development of novel therapeutic strategies to combat infectious diseases and cancer.
Metal specificity of cyanobacterial nickel-responsive repressor InrS: cells maintain zinc and copper below the detection threshold for InrS

InrS is a Ni(II)‐responsive, CsoR/RcnR‐like, DNA‐binding transcriptional repressor of the nrsD gene, but the Ni(II) co‐ordination sphere of InrS is unlike Ni(II)‐RcnR. We show that copper and Zn(II) also bind tightly to InrS and in vitro these ions also impair InrS binding to the nrsD operator‐promoter. InrS does not respond to Zn(II) (or copper) in vivo after 48 h, when Zn(II) sensor ZiaR responds, but InrS transiently responds (1 h) to both metals. InrS conserves only one (of two) second co‐ordination shell residues of CsoR (Glu98 in InrS). The allosteric mechanism of InrS is distinct from Cu(I)‐CsoR and conservation of deduced second shell residues better predicts metal specificity than do the metal ligands. The allosteric mechanism of InrS permits greater promiscuity in vitro than CsoR. The factors dictating metal‐selectivity in vivo are that KNi(II) and ΔGCNi(II)‐InrS·DNA are sufficiently high, relative to other metal sensors, for InrS to detect Ni(II), while the equivalent parameters for copper may be insufficient for copper‐sensing in Synechocystis (at 48 h). InrS KZn(II) (5.6 × 10−13 M) is comparable to the sensory sites of ZiaR (and Zur), but ΔGCZn(II)‐InrS·DNA is less than ΔGCZn(II)‐ZiaR·DNA implying that relative to other sensors, ΔGCZn(II)‐Sensor·DNA rather than KZn(II) determines the final detection threshold for Zn(II).
The Actor–Partner Interdependence Model: A model of bidirectional effects in developmental studies

The actor–partner interdependence model (APIM) is a model of dyadic relationships that integrates a conceptual view of interdependence with the appropriate statistical techniques for measuring and testing it. In this article we present the APIM as a general, longitudinal model for measuring bidirectional effects in interpersonal relationships. We also present three different approaches to testing the model. The statistical analysis of the APIM is illustrated using longitudinal data on relationship specific attachment security from 203 mother–adolescent dyads. The results support the view that interpersonal influence on attachment security is bidirectional. Moreover, consistent with a hypothesis from attachment theory, the degree to which a child’s attachment security is influenced by his or her primary caregiver is found to diminish with age.
A multivariate hierarchical model for studying psychological change within married couples.

This article illustrates new statistical methods for the study of psychological change in married couples. The design involves time-series data on each partner. The analysis combines longitudinal methods for studies of individual change with cross-sectional methods for the study of matched pairs. Each person is viewed as changing over time as a function of an individual growth curve or change function. As in previous studies of individual change, a person's trajectory depends on time-invarian t personal background characteristics and time-varying changes in the environment. However, unlike typical studies of individual change, a person's changing psychological profile depends, in part, on the influence of that person's partner. These methods apply directly to other types of longitudinal studies on families (e.g., studies that use teacher and parent reports of a child's social behavior). The methodology is flexible in allowing randomly missing data, varying spacing of time points, unbalanced designs, and time-varying and time-invariant covariates. The study of psychological change of married partners involves two basic features that have implications for conceptual and statistical models. First, each individual changes over time. Second, the change trajectories of partners are likely to be related. At minimum, the relational character of change in couples must not be ignored; it may, in fact, be of central interest in many studies. To represent this process, a pair of change functions is first specified for each couple in a Level 1 or "within-couple" model. At Level 2,
Gender Differences in Using Social Networks.

The purpose of this study is to determine individuals’ usage purposes of social networks with a focus on the possible differences between females and males. Facebook, which is one the most popular and being most widely used social network, is investigated in this study. The study group consisted of 870 Facebook users who responded an online survey designed by the researchers. Analyses of the results showed that usage purposes can be categorized under four categories, namely maintaining existing relationships, making new relationships, using for academic purposes and following specific agenda. Significant differences were found between genders in all of the purposes mentioned. While the difference on making new contacts was in favor of males, the differences on the other three user purposes were in favor of females.
Estimating Changes of Residence for Cross-National Comparison

This short paper considers a number of temporal and spatial models that can be used for international comparison of internal migration levels across all countries of the world. First, among the various spatial models used, the model linking migrations to the zoning of the territory provides a simple summary of this relationship, but its parameters do not have a clear plain language meaning for international comparison. Second, the "migrant-migration" model derives an instantaneous rate based on migrant numbers measured over variable durations that is independent of multiple and return moves occurring over a longer interval. International comparison is thus only possible for the instantaneous mobility rate (change of residence), a standard indicator whose meaning is clear. The authors use numerous examples to show that the simultaneous use of both types of models provides a means, under certain conditions, to approximate such a rate, that can be linked to the parameters of these models. The validity of these models can be tested and confirmed using data from countries where direct measures of changes of residence are available.
Housing stability among homeless individuals with serious mental illness participating in housing first programs

This article presents findings from an exploratory study of three programs using the Housing First approach to provide permanent supportive housing for single, homeless adults with serious mental illness and often co-occurring substance-related disorders. This approach provides direct, or nearly direct, access to housing that is intended to be permanent without requiring sobriety or psychiatric treatment. Findings from the three programs examined for this study indicate that the Housing First approach may help the hardest-to-serve chronically homeless population achieve housing stability. Of the 80 participants tracked over 12 months, 84% remained enrolled in the Housing First program for 1 year following program entry. One half of those spent every night in their Housing First unit, while the others spent some time in other living environments. C 2009 Wiley Periodicals, Inc.