Miracle-dz/UniFAR-FTUs huggingface dataset:
Extraclassical Receptive Field Properties of Parvocellular, Magnocellular, and Koniocellular Cells in the Primate Lateral Geniculate Nucleus

Descriptions of receptive fields at subcortical levels of the visual system have mostly considered only the classical receptive field (CRF). A suppressive extraclassical receptive field (ECRF) has been demonstrated in relay cells within the primate lateral geniculate nucleus (LGN), but the quantitative properties and specific influence of the ECRF on the distinct magnocellular (MC), koniocellular (KC), and parvocellular (PC) pathways are not known. Here we quantified the effect of ECRF stimulation on visually responsive cells in the LGN of a diurnal New World primate, the marmoset. We show that for all cells, visually evoked responses are reduced by stimulation of the ECRF. The magnitude of the suppression is greatest for MC cells and smallest for PC cells. The effect of ECRF stimulation on KC cells is variable but always suppressive. We refer to these effects as extraclassical inhibition (ECI). The contrast–response relationship of the ECI parallels that of CRF-induced excitation for each cell class: for MC cells, ECI contrast threshold is close to 10% and the ECI saturates at 50% contrast, but the contrast dependence of ECI on PC cells is more linear. The ECI also contributes to contrast-dependent changes in spatial summation: on average for all LGN cells the radius of the excitatory spatial summation field (measured from aperture-tuning curves) at low contrast is 1.31 times that at high contrast. No consistent effects of orientation on ECI were seen. The data suggest that the suppressive component of the ECRF seen in cortical neurons could primarily be inherited from subcortical input streams.
Examining Public Preferences for the Allocation of Resources to Rehabilitative Versus Punitive Crime Policies

Fear of crime has been recognized as one of the driving forces underlying the punitive turn in the criminal justice system. Despite this, evidence suggests that rehabilitative efforts are still supported by the general public. The current study uses a national random sample to examine the impact of fear on public preference for allocating resources to rehabilitative versus punitive criminal justice system policies. Contrary to prior studies, respondents are forced to make a choice between punitive and rehabilitative options, and both the emotional and cognitive aspects of crime salience—fear of crime and victimization risk—are evaluated to determine their independent and combined impact on crime policy preference. The findings suggest that the majority of the public prefers putting resources toward rehabilitative crime polices, but fear of crime and risk of victimization both reduce this tendency. The implications of our results for current criminal justice system policies are discussed.
Patch Testing in Patients with Suspected Footwear Dermatitis: A Retrospective Study

Background: Footwear dermatitis represents a common but often undiagnosed or misdiagnosed condition. Patch testing aids in its confirmation and identification of the offending allergen. Aims: This study aimed to find the frequency of positive patch test reactions in cases with suspected allergic contact dermatitis (ACD) to footwear, as well as the common responsible allergens. Materials and Methods: This is a retrospective record based study of 37 patients, with suspected ACD to footwear, who underwent patch testing with Indian standard series and Indian footwear series from July 2012 to July 2015. Results: The majority of patients (45.94%) belonged to the age group of 20–40 years. Dorsal aspects of feet (81.08%) and soles (18.92%) were the common sites involved. Patch test was positive in 18.92% patients. The most common causative allergens were hydroquinone monobenzylether (8.11%) and 4-aminoazobenzene (5.41%). Conclusion: Common chemicals implicated in ACD were rubber, rubber additives, and dyes. The principal culprit allergens were hydroquinone monobenzylether and 4-aminoazobenzene.
Divide‐and‐allocate: An uplink successive bandwidth division NOMA system

This paper investigates a new spectrum‐sharing strategy using non‐orthogonal multiple access (NOMA), a technique that is expected to lead toward the fifth generation of wireless networks. The proposed scheme, namely, successive bandwidth division (SBD), NOMA, is a hybrid approach exploiting the characteristics of both the conventional NOMA system and the orthogonal multiple access (OMA) system. Power allocation is being performed in successive bandwidth division NOMA to maximize the sum rate using a divide‐and‐allocate approach such that all users are allocated with optimal transmission power. Under Rayleigh fading, the probability density function (PDF) of the received signal‐to‐interference‐plus‐noise ratio (SINR) is derived, and closed‐form expressions for the outage probability are presented when channel state information (CSI) is available at the base station. The performance evaluation is carried out in terms of receiver complexity, average sum rate, and outage probability. Simulations results are provided to access and compare the performance of the proposed scheme with other contemporary approaches.
Completeness Before Post: Bernays, Hilbert, and the Development of Propositional Logic

Abstract Some of the most important developments of symbolic logic took place in the 1920s. Foremost among them are the distinction between syntax and semantics and the formulation of questions of completeness and decidability of logical systems. David Hilbert and his students played a very important part in these developments. Their contributions can be traced to unpublished lecture notes and other manuscripts by Hilbert and Bernays dating to the period 1917–1923. The aim of this paper is to describe these results, focussing primarily on propositional logic, and to put them in their historical context. It is argued that truth-value semantics, syntactic (“Post-”) and semantic completeness, decidability, and other results were first obtained by Hilbert and Bernays in 1918, and that Bernays's role in their discovery and the subsequent development of mathematical logic is much greater than has so far been acknowledged.
The emergence and scaling of division of labor in insect societies

Division of labor is a pervasive feature of animal societies, but little is known about the causes or consequences of division of labor in non-eusocial cooperative groups. We tested whether division of labor self-organizes in an incipient social system: artificially induced nesting associations of the normally solitary sweat bee Lasioglossum (Ctenonomia) NDA-1 (Hymenoptera: Halictidae). We quantified task performance and construction output by females nesting either alone or with a conspecific. Within pairs, a division of labor repeatedly arose in which one individual specialized on excavation and pushing/tamping while her nestmate guarded the nest entrance. Task specialization could not be attributed to variation in overall activity, and the degree of behavioral differentiation was greater than would be expected due to random variation, indicating that division of labor was an emergent phenomenon generated in part by social dynamics. Excavation specialists did not incur a survival cost, in contrast to previous findings for ant foundress associations. Paired individuals performed more per capita guarding, and pairs collectively excavated deeper nests than single bees – potential early advantages of social nesting in halictine bees.
Intravitreal and Subconjunctival Melphalan for Retinoblastoma in Transgenic Mice

Purpose. To measure the chemotherapeutic effects of focal melphalan (intravitreal and subconjunctival) on tumor burden, hypoxia, and vasculature in LHBETATAG murine retinoblastoma model. Methods. LHBETATAG transgenic mice were treated with a single 1 mcg intravitreal injection of melphalan, 100 mcg subconjunctival injection, or semiweekly 10 mcg subconjunctival injections for 3 weeks. At 1 or 3 weeks, eyes were enucleated, serially sectioned, and processed with haematoxylin and eosin (H&E) for tumor burden measurements and probed with immunofluorescence to analyze tumor hypoxia and vasculature. Results. Focal melphalan significantly reduced retinal tumor size (P < 0.02) when given intravitreally or subconjunctivally. Eyes treated with a one-time intravitreal injection of 1 mcg melphalan had significantly smaller tumors at both 1 week (P = 0.017) and at 3 weeks after injection (P = 0.005). Intratumoral hypoxia showed a significant decline in hypoxia at 1 week following intravitreal injection and after maximum dosage of subconjunctival melphalan. Total vasculature was not significantly affected following intravitreal administration. Conclusion. Focal delivery of melphalan via intravitreal or subconjunctival injection has a significant effect on reducing tumor burden, hypoxia, and vasculature, in the treatment of murine retinoblastoma tumors.
Inhalation Toxicology of Ricin Preparations: Animal Models, Prophylactic and Therapeutic Approaches to Protection

Ricin is a toxin and seed protein produced by the castor oil plant, Ricinus communis. The toxin is a dimeric protein consisting of an enzymic A chain and a B chain with lectin properties aiding the uptake of the whole molecule into cells. Ricin has been considered a possible military threat for several decades and is now also of some concern as a terrorist agent. The inhalation route is of primary concern in these situations, although previous attacks with ricin have used other approaches. Medical countermeasures against ricin are urgently required and the strategy adopted has been first to understand the nature of the problem, in this case the inhalation toxicology of ricin, followed by the preparation of vaccine antigens. Toxoided ricin and modified recombinant A chain components have been examined in terms of efficacy as potential vaccine candidates in protection of animal models against inhaled ricin, primarily in laboratories both in the United Kingdom and in the United States. One recombinant A chain vaccine has been taken through to clinical trials in the United States and should become commercially available in the next few years. Toxoided ricin has also been used as an antigen to prepare antitoxin antibodies for therapeutic treatment following poisoning. In this review, a synopsis of the inhalation toxicology of ricin and approaches to medical prophylaxis and therapy of poisoning is given, based on work conducted at our laboratory and at other research institutes.
Determinants of importer commitment in international exchange: An agenda for future research

Abstract Commitment has received great attention in the inter-organisational relationship literature but there is widespread debate and contention on what constitutes its key determinants, specifically in an import supplier context. Furthermore, inconsistencies in empirical findings of the buyer–seller relationship studies limit the theoretical development and use of internationalization theories in management practice. Yet this area warrants attention as it may assist in enabling the integration of the spectrum of importer commitment in the importer–exporter relationship. Essentially, this paper integrates and synthesises over eighty conceptual and empirical studies on commitment in the buyer–seller relationship from different contexts including grounding on internationalisation process theory, resource based theory of the firm and transaction costs economics. Conceptual arguments are assessed and empirical findings are evaluated across studies with the aim of developing a framework. With the support of three basic theories and extant literature, ten antecedents of importer commitment are identified. The causal direct and some indirect relationships are specified. Seventeen propositions are offered to guide future research efforts in this important field.
Twitter Early Tsunami Warning System: A Case Study in Indonesia's Natural Disaster Management

Twitter demonstrated its value as a viable substitute to traditional communication channels during the recent disasters. However, little is written about Twitter in government for an early disaster warning system. In this exploratory empirical research, we aim to address the question: How does the government use Twitter to inform the public about disaster hazards and vulnerability? Case study and tweets content analysis are conducted on Indonesia's Twitter early tsunami warning system to answer the question in the context of the three earthquakes occurred off the west coast of Sumatra during the period of 2010-2012. Data are collected from egovernment websites of agencies involved in disaster preparedness and response. This research concludes that the Twitter-based warning system demonstrated its value as a viable complement to Indonesia's InaTEWS - a comprehensive disaster information management system for governments - by informing the public and creating public value through its communication speed, reach and information quality.
Effects of storage temperature on airway exosome integrity for diagnostic and functional analyses

ABSTRACT Background: Extracellular vesicles contain biological molecules specified by cell-type of origin and modified by microenvironmental changes. To conduct reproducible studies on exosome content and function, storage conditions need to have minimal impact on airway exosome integrity. Aim: We compared surface properties and protein content of airway exosomes that had been freshly isolated vs. those that had been treated with cold storage or freezing. Methods: Mouse bronchoalveolar lavage fluid (BALF) exosomes purified by differential ultracentrifugation were analysed immediately or stored at +4°C or −80°C. Exosomal structure was assessed by dynamic light scattering (DLS), transmission electron microscopy (TEM) and charge density (zeta potential, ζ). Exosomal protein content, including leaking/dissociating proteins, were identified by label-free LC-MS/MS. Results: Freshly isolated BALF exosomes exhibited a mean diameter of 95 nm and characteristic morphology. Storage had significant impact on BALF exosome size and content. Compared to fresh, exosomes stored at +4°C had a 10% increase in diameter, redistribution to polydisperse aggregates and reduced ζ. Storage at −80°C produced an even greater effect, resulting in a 25% increase in diameter, significantly reducing the ζ, resulting in multilamellar structure formation. In fresh exosomes, we identified 1140 high-confidence proteins enriched in 19 genome ontology biological processes. After storage at room temperature, 848 proteins were identified. In preparations stored at +4°C, 224 proteins appeared in the supernatant fraction compared to the wash fractions from freshly prepared exosomes; these proteins represent exosome leakage or dissociation of loosely bound “peri-exosomal” proteins. In preparations stored at −80°C, 194 proteins appeared in the supernatant fraction, suggesting that distinct protein groups leak from exosomes at different storage temperatures. Conclusions: Storage destabilizes the surface characteristics, morphological features and protein content of BALF exosomes. For preservation of the exosome protein content and representative functional analysis, airway exosomes should be analysed immediately after isolation.
A Stepped-Wedge Evaluation of an Initiative to Spread the Collaborative Care Model for Depression in Primary Care

PURPOSE Scale-up and spread of evidence-based practices is one of the most important challenges facing health care. We tested whether a statewide initiative, Depression Improvement Across Minnesota–Offering a New Direction (DIAMOND), to implement the collaborative care model for depression in 75 primary care clinics resulted in patient outcome improvements corresponding to those reported in randomized controlled trials. METHODS Health plans provided a new monthly payment to participating clinics after a 6-month intensive training program with ongoing data submission, networking, and consultation. Implementation was staggered, with 5 sequences of 10 to 40 clinics every 6 months. Payers provided weekly contact information for members from participating clinics who were filling antidepressant prescriptions, and we conducted baseline and 6-month surveys of 1,578 patients about their care and outcomes. RESULTS There were 466 patients in DIAMOND clinics who received usual care before implementation (UCB), 559 who received usual care in DIAMOND clinics after implementation (UCA), 245 who received DIAMOND care after implementation (DCA), and 308 who received usual care in comparison clinics (UC). Patients who received DIAMOND care after implementation reported more collaborative care depression services than the 3 comparison groups (10.9 vs 6.4–6.7, on a scale of 0 of 14, where higher numbers indicate more services; P <.001) and more satisfaction with their care (4.0 vs 3.4 on a scale 1 to 5, in which higher scores indicate higher satisfaction; P ≤.001). Depression remission rates, however, were not significantly different among the 4 groups (36.4% DCA vs 35.8% UCB, 35.0% UCA, 33.9% UC; P = .94). CONCLUSIONS Despite the incentive of a supporting payment change and intensive training and support for clinics volunteering to participate, no difference in depression outcomes was documented. Specific unmeasured actions present in trials but not present in these clinics may be critical for successful outcome improvement.
Structural Features of N-Glycans Linked to Royal Jelly Glycoproteins: Structures of high-mannose type, hybrid type, and biantennary type glycans

The structures of N-glycans of total glycoproteins in royal jelly have been explored to clarify whether antigenic N-glycans occur in the famous health food. The structural feature of N-glycans linked to glycoproteins in royal jelly was first characterized by immunoblotting with an antiserum against plant complex type N-glycan and lectin-blotting with Con A and WGA. For the detail structural analysis of such N-glycans, the pyridylaminated (PA-) N-glycans were prepared from hydrazinolysates of total glycoproteins in royal jelly and each PA-sugar chain was purified by reverse-phase HPLC and size-fractionation HPLC. Each structure of the PA-sugar chains purified was identified by the combination of two-dimensional PA-sugar chain mapping, ESI-MS and MS/MS analyses, sequential exoglycosidase digestions, and 500 MHz 1H-NMR spectrometry. The immunoblotting and lectinblotting analyses preliminarily suggested the absence of antigenic N-glycan bearing β1-2 xylosyl and/or α1-3 fucosyl residue(s) and occurrence of β1-4GlcNAc residue in the insect glycoproteins. The detailed structural analysis of N-glycans of total royal jelly glycoproteins revealed that the antigenic N-glycans do not occur but the typical high mannose-type structure (Man9~4GlcNAc2) occupies 71.6% of total N-glycan, biantennary-type structures (GlcNAc2Man3GlcNAc2) 8.4%, and hybrid type structure (GlcNAc1Man4GlcNAc2) 3.0%. Although the complete structures of the remaining 17% N-glycans; C4, (HexNAc3Hex3HexNAc2: 3.0%), D2 (HexNAc2Hex5HexNAc2: 4.5%), and D3 (HexNAc3Hex4HexNAc2: 9.5%) are still obscure so far, ESI-MS analysis, exoglycosidase digestions by two kinds of β-N-acetylglucosaminidase, and WGA blotting suggested that these N-glycans might bear a β1-4 linkage N-acetylglucosaminyl residue.
Diversification, Coordination Costs and Organizational Rigidity: Evidence from Microdata

This paper examines the impact of coordination costs and organizational rigidity on the returns to diversification. The central thesis is that coordination costs offset economies of scope, while organizational rigidity increases coordination costs, further constraining economies of scope. The empirical tests of this proposition identify the effects of coordination and organizational rigidity costs on business-unit and firm productivity, using novel data from the Economic Census on taxicab and limousine firms. The key results show that coordination and organizational rigidity costs are economically and statistically significant, while organizational rigidity itself accounts for a 16% decrease in paid ride-miles per taxicab in incumbent diversifiers, controlling for the other costs and benefits of diversification and incumbency. The findings suggest that coordination costs, in general, and organizational rigidity costs, in particular, limit the scope of the firm.
Teen Mother Perceptions of Support Program Influences on Self-efficacy, Parenting-efficacy, and School Success

13 CHAPTER ONE: INTRODUCTION . 14 Purpose of the Study . 14 Background and Rationale . 15 Problem Statement . 19 Research Questions . 20 Definition of Terms . 21 Assumptions . 25 Summary . 26 CHAPTER TWO: LITERATURE REVIEW . 28 Introduction . 28 Historical Context . 30 Passing and Implementation of Title IX . 31 Challenges of Teen Pregnancy and Parenting . 34 SUPPORT PROGRAM INFLUENCES 8 Identity Development . 38 Psychological Well-Being . 39 Funding for Programs . 44 Support Program Variation . 46 Reforming Laws to Address Teen Mothers . 48 Theoretical Context . 52 Self-Efficacy Theory . 53 Consequences of Self-Efficacy Beliefs . 56 Implications for School and Support Programs . 58 Summary . 59 CHAPTER THREE: METHODS AND PROCEDURES . 6
Marital quality and loneliness in later life

Loneliness is not merely an unpleasant experience but is harmful for older adults’ health and well-being as well. While marriage buffers against loneliness in later life, even married adults experience loneliness, and aspects of adults’ marriages may either protect against or actually foster loneliness among spouses. The current study analyzed dyadic data from 1,114 opposite-sex married Irish couples who participated in the initial wave of The Irish Longitudinal Study on Ageing (2009–2011) in order to extend findings of two prior dyadic studies of marital quality and loneliness in the U.S. to older married couples in Ireland and to directly compare two theoretical and methodological frameworks used by these studies to explain associations between husbands’ and wives’ reports of marital quality and loneliness in later life. Results revealed that both spouses’ perceptions of positive and negative marital quality were significantly related with husbands’ and wives’ loneliness and that spouses’ reports of loneliness were significantly related with one another. Findings also indicated that associations between marital quality and loneliness were similar for Irish and American couples in later life. Comparison of differing modeling strategies suggested that emotional contagion may serve as a pathway for dyadic partner effects.
Learning Representations of Affect from Speech

There has been a lot of prior work on representation learning for speech recognition applications, but not much emphasis has been given to an investigation of effective representations of affect from speech, where the paralinguistic elements of speech are separated out from the verbal content. In this paper, we explore denoising autoencoders for learning paralinguistic attributes i.e. categorical and dimensional affective traits from speech. We show that the representations learnt by the bottleneck layer of the autoencoder are highly discriminative of activation intensity and at separating out negative valence (sadness and anger) from positive valence (happiness). We experiment with different input speech features (such as FFT and log-mel spectrograms with temporal context windows), and different autoencoder architectures (such as stacked and deep autoencoders). We also learn utterance specific representations by a combination of denoising autoencoders and BLSTM based recurrent autoencoders. Emotion classification is performed with the learnt temporal/dynamic representations to evaluate the quality of the representations. Experiments on a well-established real-life speech dataset (IEMOCAP) show that the learnt representations are comparable to state of the art feature extractors (such as voice quality features and MFCCs) and are competitive with state-of-the-art approaches at emotion and dimensional affect recognition.