Miracle-dz/UniFAR-FTUs huggingface dataset:
Myeloid cell differentiation in response to calcitriol for expression CD11b and CD14 is regulated by myeloid zinc finger‐1 protein downstream of phosphatidylinositol 3‐kinase

Immature cells of the mononuclear phagocyte series differentiate in response to calcitriol. This is accompanied by increased expression of both CD11b and CD14 and has been shown to be phosphatidylinositol 3‐kinase (PI3K) dependent. The events downstream of PI3K that regulate mononuclear phagocyte gene expression, however, remain to be fully understood. In the present study, we show that incubation of THP‐1 cells with calcitriol brings about activation of the myeloid zinc finger‐1 (MZF‐1) transcription factor dependent upon PI3K. In addition, we show that the proximal promoter regions of both CD11b and CD14 contain functional MZF‐1 binding sites that are calcitriol responsive. Site‐directed mutagenesis of the putative MZF‐1 elements abolished MZF‐1 binding to the promoters of both CD11b and CD14. Not only did calcitriol treatment increase MZF‐1 DNA binding activity to these sites, but it also up‐regulated cellular levels of MZF‐1. Silencing of MZF‐1 resulted in a markedly blunted response to calcitriol for induction of both CD11b and CD14 mRNA transcript levels. Cell surface expression of CD11b and CD14 was also reduced, but to a lesser extent. Taken together, these results show that MZF‐1 is involved downstream of PI3K in a calcitriol‐induced signaling pathway leading to myeloid cell differentiation and activation of CD11b and CD14.
Entrepreneurial Elements and Environmental Sustainability Orientation: A Relationship Exploration

This study looks at the sustainable orientation and entrepreneurial elements among secondary school students in Seremban, Negeri Sembilan, from the perspective of subject stream specialization. The sample consists of 384 Form Four students from six secondary government schools. The samples are chosen randomly and by cluster. The questionnaire instrument is used to look at three main aspects: sustainable orientation, life values and entrepreneurial elements, in addition to demographic factors. The research data are analyzed descriptively and inferentially. Science stream students display a better environmental attitude than non-science stream students, but their environmental behavior is not as good. Science stream students also show better life values and entrepreneurial elements than the non-science students. There is a positive correlation between entrepreneurship, life values elements and sustainable orientation. On the whole, the findings indicate that students have a moderate level of sustainable orientation while entrepreneurship is at a high level. The results of this study are expected to assist teachers, Ministry of Education Malaysia and other related parties to develop strategies towards improvement of sustainable entrepreneurship.
Blind source separation of acoustic signals in realistic environments based on ICA in the time-frequency domain

We present an approach for blind separation of acoustic sources produced from multiple speakers mixed in realistic room environments. We first transform recorded signals into the time‐frequency domain to make mixing become instantaneous. We then separate the sources in each frequency bin based on an independent component analysis (ICA) algorithm. For the present paper, we choose the complex version of fixedpoint iteration (CFPI), i.e. the complex version of FastICA, as the algorithm. From the separated signals in the time‐frequency domain, we reconstruct output‐separated signals in the time domain. To solve the so‐called permutation problem due to the indeterminacy of permutation in the standard ICA, we propose a method that applies a special property of the CFPI cost function. Generally, the cost function has several optimal points that correspond to the different permutations of the outputs. These optimal points are isolated by some non‐optimal regions of the cost function. In different but neighboring bins, optimal points with the same permutation are at almost the same position in the space of separation parameters. Based on this property, if an initial separation matrix for a learning process in a frequency bin is chosen equal to the final separation matrix of the learning process in the neighboring frequency bin, the learning process automatically leads us to separated signals with the same permutation as that of the neighbor frequency bin. In each bin, but except the starting one, by chosen the initial separation matrix in such a way, the permutation problem in the time domain reconstruction can be avoided. We present the results of some simulations and experiments on both artificially synthesized speech data and real‐world speech data, which show the effectiveness of our approach.
A Genetic Programming Approach to Record Deduplication

Several systems that rely on consistent data to offer high-quality services, such as digital libraries and e-commerce brokers, may be affected by the existence of duplicates, quasi replicas, or near-duplicate entries in their repositories. Because of that, there have been significant investments from private and government organizations for developing methods for removing replicas from its data repositories. This is due to the fact that clean and replica-free repositories not only allow the retrieval of higher quality information but also lead to more concise data and to potential savings in computational time and resources to process this data. In this paper, we propose a genetic programming approach to record deduplication that combines several different pieces of evidence extracted from the data content to find a deduplication function that is able to identify whether two entries in a repository are replicas or not. As shown by our experiments, our approach outperforms an existing state-of-the-art method found in the literature. Moreover, the suggested functions are computationally less demanding since they use fewer evidence. In addition, our genetic programming approach is capable of automatically adapting these functions to a given fixed replica identification boundary, freeing the user from the burden of having to choose and tune this parameter.
Political Concepts and the Concept of the Political

Although concepts are typically assumed to be at the core of both the language of politics and the language of political inquiry, the meaning of “concept” has remained notoriously vague. In everyday usage, prominent elements of philosophy, and the literature of political science and political theory, concepts are, however, primarily assumed to be mental phenomena that are expressed in words and actions. This assumption has been challenged by Ludwig Wittgenstein, Gilbert Ryle, and a variety of contemporary philosophers who claim that human thought is primarily linguistic. This suggests that concepts are best understood as forms of linguistic usage. The concept-word “politics” refers to a culturally and historically variable category of social phenomena, and it is a mistake to assume that the phrase “the political” designates a theoretical concept.
In Search of Concepts : Returns , Trading Volume and Speculative Demand ∗

Using a novel proxy of investors’ speculative demand constructed from online search interest in “concept stocks”, we examine how speculative demand affects the returns and trading volume of Chinese stock indices. We find that returns and trading volume increase with the contemporaneous speculative demand. In addition, the high speculative demand causes lower near future returns, while recent high past returns cause the high speculative demand. Moreover, the speculative demand explains more variation in returns and trading volume of A shares (more populated by retail investors) than B shares (less populated by retail investors). Our findings support the attention theory of Barber and Odean (2008).
Therapeutics Role of Azadirachta indica (Neem) and Their Active Constituents in Diseases Prevention and Treatment

Neem (Azadirachta indica) is a member of the Meliaceae family and its role as health-promoting effect is attributed because it is rich source of antioxidant. It has been widely used in Chinese, Ayurvedic, and Unani medicines worldwide especially in Indian Subcontinent in the treatment and prevention of various diseases. Earlier finding confirmed that neem and its constituents play role in the scavenging of free radical generation and prevention of disease pathogenesis. The studies based on animal model established that neem and its chief constituents play pivotal role in anticancer management through the modulation of various molecular pathways including p53, pTEN, NF-κB, PI3K/Akt, Bcl-2, and VEGF. It is considered as safe medicinal plants and modulates the numerous biological processes without any adverse effect. In this review, I summarize the role of Azadirachta indica in the prevention and treatment of diseases via the regulation of various biological and physiological pathways.
Choice, chance, and inevitability in strategy

We propose a theory to manage the uneasy relation between strategic choice, chance, and determinism (or inevitability). To do so, we locate arguments in intellectual history that have a clear bearing on this relation. We introduce and defend four conjectures that outline the relationship between each of them and their comparative significance. The paper thus aims at achieving three objectives: (a) to articulate a philosophically sustainable theory of strategic choice that corroborates experience (without being induced by it); (b) to synthesize what remains one of the most sustained debates in strategy, namely the nature, role, and relation of choice, chance and determinism; and (c) to contribute to developing a foundation for multilevel research.
Teaching large classes at an Institution of Higher Learning in South Africa

In line with the notions of increased access to education as well as massification of education in South Africa and elsewhere, large classes have become common in Universities. While the size of a large class varies from country to country, in a South African context, and at our institution in particular, large classes can mean approximately 120 students in one seating. Although large classes can have a negative effect on student participation and engagement, especially when dealing with first year students, some strategies could be devised to deal with large classes. This study was undertaken to examine the problems students and lecturers experience in large classes as well as strategies that the lecturers have devised in promoting and sustaining student participation and engagement. The setting of the study is the Central University of Technology, Free State, an institution of Higher Learning in the Free State province of South Africa. The population for the study were first-year education students in 2017. A sample of 248 first year education students, from different areas of specialisation was used in the study. A self-constructed questionnaire was used to collect data from the students while semi-structured interviews were used to collect data from the lecturers. The findings revealed that large classes do pose challenges to both students and lecturers. However, both students and lecturers have developed strategies of dealing with large classes. Lecturers have resorted to team teaching, group assignments, and team marking. Students have benefitted from group assignments and group presentations as such activities afforded them opportunities to work collaboratively with one another. Although there is limited participation in class as there is no individual attention, within the groups, they are able to participate and engage with one another. The institution is charged with the responsibility to expand its facilities as the students cannot be turned away.
RED CELLS , IRON , AND ERYTHROPOIESIS Acute hemolytic vascular in fl ammatory processes are prevented by nitric oxide replacement or a single dose of hydroxyurea

Hematology Center, University of Campinas (UNICAMP), Campinas, Brazil; Instituto Israelita de Ensino e Pesquisa Albert Einstein, Hospital Israelita Albert Einstein, São Paulo, Brazil; Faculty of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil; Department of Genetics, Evolution and Bioagents, and Department of Biochemistry and Tissue Biology, Institute of Biology, UNICAMP, Campinas, Brazil
Opening up the family archive

The Family Archive device is an interactive multi-touch tabletop technology with integrated capture facility for the archiving of sentimental artefacts and memorabilia. It was developed as a technology probe to help us open up current family archiving practices and to explore family archiving in situ. We detail the deployment and study of three of these devices in family homes and discuss how deploying a new, potentially disruptive, technology can foreground the social relations and organizing systems in domestic life. This in turn facilitates critical reflection on technology design.
The Vimos VLT deep survey Global properties of 20 000 galaxies in the IAB < 22.5 WIDE survey

The VVDS-Wide survey has been designed to trace the large-scale distribution of galaxies at z ~ 1 on comoving scales reaching ~100~h-1 Mpc, while providing a good control of cosmic variance over areas as large as a few square degrees. This is achieved by measuring redshifts with VIMOS at the ESO VLT to a limiting magnitude IAB = 22.5, targeting four independent fields with sizes of up to 4 deg2 each. We discuss the survey strategy which covers 8.6 deg2 and present the general properties of the current redshift sample. This includes 32 734 spectra in the four regions, covering a total area of 6.1 deg2 with a sampling rate of 22 to 24%. This paper accompanies the public release of the first 18 143 redshifts of the VVDS-Wide survey from the 4 deg2 contiguous area of the F22 field at RA = 22^h. We have devised and tested an objective method to assess the quality of each spectrum, providing a compact figure-of-merit. This is particularly effective in the case of long-lasting spectroscopic surveys with varying observing conditions. Our figure of merit is a measure of the robustness of the redshift measurement and, most importantly, can be used to select galaxies with uniform high-quality spectra to carry out reliable measurements of spectral features. We also use the data available over the four independent regions to directly measure the variance in galaxy counts. We compare it with general predictions from the observed galaxy two-point correlation function at different redshifts and with that measured in mock galaxy surveys built from the Millennium simulation. The purely magnitude-limited VVDS Wide sample includes 19 977 galaxies, 304 type I AGNs, and 9913 stars. The redshift success rate is above 90% independent of magnitude. A cone diagram of the galaxy spatial distribution provides us with the current largest overview of large-scale structure up to z ~ 1, showing a rich texture of over- and under-dense regions. We give the mean N(z) distribution averaged over 6.1 deg2 for a sample limited in magnitude to IAB = 22.5. Comparing galaxy densities from the four fields shows that in a redshift bin Δz = 0.1 at z ~ 1 one still has factor-of-two variations over areas as large as ~ 0.25 deg2. This level of cosmic variance agrees with that obtained by integrating the galaxy two-point correlation function estimated from the F22 field alone. It is also in fairly good statistical agreement with that predicted by the Millennium simulations. The VVDS WIDE survey currently provides the largest area coverage among redshift surveys reaching z ~ 1. The variance estimated over the survey fields shows explicitly how clustering results from deep surveys of even 1 deg2 size should be interpreted with caution. The survey data represent a rich data base to select complete sub-samples of high-quality spectra and to study galaxy ensemble properties and galaxy clustering over unprecedented scales at these redshifts. The redshift catalog of the 4 deg2 F22 field is publicly available at http://cencosw.oamp. fr.
The effect of transformational leadership on organizational citizenship behavior mediated by job satisfaction and organizational commitment : Study at Islamic Bank in Malang Raya

Organizational Citizenship Behavior (OCB) has an effect on organization effectiveness. This behavior has important consequences in workplace. OCB can contribute to organizational effectiveness through improved performance, enabling the organization to adapt to changes in environment, and strengthen coordination in working group. Because the effect on organizational effectiveness, it is important to investigate variables that can improve Employee OCB in organization. This study aims to investigate the effect of transformational leadership on OCB, to determine the effect of job satisfaction on organizational commitment, to identify the role of job satisfaction and organizational commitment to mediate the effect of transformational leadership on OCB. The population was all employees at Bank Shariah, consists of Bank Mandiri Shariah, BTN Shariah, BNI shariah, and BRI Shariah with total 436 employees. Samples are 140 full time employees selected by proportional random sampling technique. Data is collected directly from respondents by questionnaires and analyzed by PLS. The results showed that transformational leadership has no significant effect on OCB, job satisfaction affect on organizational commitment, job satisfaction mediates the effect of transformational leadership on OCB and organizational commitment mediates the effect of transformational leadership on OCB.
Media-Education Convergence: Applying Transmedia Storytelling Edutainment in E-Learning Environments

In the era of media convergence, transmedia (cross-media/cross-platform/multi-platform) narratives are catering to users who are willing to immerse themselves in their favorite entertainment content. The inherent interactivity of the Internet and the emotional engagement of story can lead to innovative pedagogies in media rich environments. This paper focuses on Web-Based Transmedia Storytelling Edutainment as a pedagogical practice in higher education.
Retailers' Incentive to Sell through a New Selling Channel and Pricing Behavior in a Multi-channel Environment

We consider a duopoly market in which two retailers with different reputation compete in prices and one of the retailers is considering selling through a new channel. Consumers are reputation sensitive and averse to the new channel. In addition, the reputation sensitivity and new channel aversion are heterogeneous across consumers. In such a setting, we find that, there must be some cost reduction for the good reputation retailer to have an incentive to sell through a new channel unless consumers are sufficiently averse to the new channel. The good reputation retailer may keep or withdraw its old channel and may coexist with the bad reputation retailer or drive it out of the market, depending on the combination of cost reduction and the degree of consumers' aversion to the new channel. On the contrary, even if cost increases by a small amount, the bad reputation retailer also has an incentive to sell through the new channel. The bad reputation retailer always withdraws the old channel, and it may coexist with the good reputation retailer or drive it out of the market, depending on the cost difference between its two channels.
Does trade liberalization enhance income growth and equity in Zimbabwe?: the role of complimentary policies

Using an agriculture-focused CGE model for Zimbabwe with 1991 as base period, this paper examines quantitatively the income and equity effects of trade liberalization in isolation and in conjunction with potentially complementary changes in fiscal and land policies. Trade policy reform alone (dismantling of import and foreign exchange controls, and reduction of import taxes to a low uniform rate) is shown to increase aggregate disposable household income significantly. However, the least income gain accrues to smallholder farm households, which account for about four-fifths of the poor in Zimbabwe, so the equity impact is unfavorable. Concurrent implementation with specific changes in government expenditure and tax policies and two alternative stylized land redistribution schemes yields differing outcomes in terms of aggregate household income growth and its distribution.
A top-heavy stellar initial mass function in starbursts as an explanation for the high mass-to-light ratios of ultra-compact dwarf galaxies

It has been recently shown that the dynamical V-band mass-to-light ratios of compact stellar systems with masses from 10 6 to 10 8 Mare not consistent with the predictions from simple stellar population models. Top-heavy stellar initial mass functions (IMFs) in these so-called ultra-compact dwarf galaxies (UCDs) offer an attractive explanation for this finding, the stellar remnants and retained stellar envelopes providing the unseen mass. We therefore construct a model which quantifies by how much the IMFs of UCDs would have to deviate in the intermediate- and high-mass range from the canonical IMF in order to account for the enhanced M/LV ratio of the UCDs. The deduced high-mass IMF in the UCDs depends on the age of the UCDs and the number of faint products of stellar evolution retained by them. Assuming that the IMF in the UCDs is a three-part power law equal to the canonical IMF in the low-mass range and taking 20 per cent as a plausible choice for the fraction of the remnants of high-mass stars retained by UCDs, the model suggests the exponent of the high-mass IMF to be ≈1.6 if the UCDs are 13 Gyr old (i.e. almost as old as the Universe) or ≈1.0 if the UCDs are 7 Gyr old, in contrast to 2.3 for the Salpeter-Massey IMF. If the IMF was as top heavy as suggested here, the stability of the UCDs might have been threatened by heavy mass loss induced by the radiation and evolution of massive stars. The central densities of UCDs must have been in the range 10 6 to 10 7 Mpc −3 when they formed with star formation rates of 10 to 100 Myr −1 .
Postpartum Ovarian Vein Thrombosis: Two Cases and Review of Literature

Introduction. We presented two cases of late presentation of ovarian vein thrombosis postpartum following vaginal delivery and cesarean section within a short period in our institution. Both of them had pelvic pain following their deliveries which was associated with fever and chills. One of them was quite a big-sized thrombophlebitic vein which was about 10 × 6 × 5 centimeters following a computed tomography. They were both treated initially for urinary tract infection, while a large ovarian vein thrombosis was not diagnosed in the second patient until her emergency department admission. Conclusion. Ovarian vein thrombosis is rare, but could present late, and difficult to diagnose, hence, should be considered as a differential diagnosis in a postpartum woman with fever and tender pelvic mass.