Miracle-dz/UniFAR-FTUs huggingface dataset:
Abnormal resting brain activity in patients with functional dyspepsia is related to symptom severity.

BACKGROUND & AIMS Abnormal processing of visceral sensation at the level of the central nervous system is believed to be involved in functional dyspepsia. However, compared with studies of stimulation-related changes in brain activity, few studies have focused on resting brain activity, which also is important in pathogenesis. We mapped changes in resting brain glucometabolism of patients with functional dyspepsia, compared with healthy subjects, and attempted to correlate abnormal brain activity with symptom severity. METHODS We performed fluorodeoxyglucose positron emission tomography-computed tomography on 40 patients with functional dyspepsia and 20 healthy subjects who were in resting states. The symptom index of dyspepsia and the Nepean dyspepsia index were used to determine symptom severity. The positron emission tomography-computed tomography data were analyzed using statistical parametric mapping software. RESULTS Compared with healthy subjects, patients with functional dyspepsia had higher levels of glycometabolism in the bilateral insula, anterior cingulate cortex (ACC), middle cingulate cortex (MCC), cerebellum, thalamus, prefrontal cortex, precentral gyrus, postcentral gyrus, middle temporal gyrus, superior temporal gyrus, putamen, right parahippocampal gyrus, claustrum, and left precuneus (P < .001). The signal increase in the ACC, insula, thalamus, MCC, and cerebellum was correlated with symptom index of dyspepsia scores and Nepean dyspepsia index scores (P < .01). The glycometabolism in ACC, insula, thalamus, MCC, and cerebellum of patients with more severe functional dyspepsia was significantly higher than that of patients with less severe functional dyspepsia (P < .005). CONCLUSIONS In patients with functional dyspepsia, resting cerebral glycometabolism differs significantly from that of healthy subjects. The ACC, insula, thalamus, MCC, and cerebellum might be the key regions that determine the severity of symptoms.
Examination of 209 Drugs for Inhibition of Cytochrome P450 2C8

Cytochrome P450 2C8 is involved in the metabolism of drugs such as paclitaxel, repaglinide, rosiglitazone, and cerivastatin, among others. An in vitro assessment of 209 frequently prescribed drugs and related xenobiotics was carried out to examine their potential to inhibit CYP2C8. A validated sensitive, moderate‐throughput high‐performance liquid chromatography/tandem mass spectrometry (HPLC/MS/MS) assay was used to detect N‐desethylamodiaquine, the CYP2C8‐derived major metabolite of amodiaquine metabolism, using heterologously expressed recombinant CYP2C8 (rhCYP2C8) and pooled human liver microsomes. The 209 drugs were first tested at 30 μM for their ability to inhibit rhCYP2C8. Forty‐eight compounds exhibited greater than 50% inhibition and were further evaluated for measurement of IC50. The six most potent inhibitors (IC50 <1 μM) from this set were measured for IC50 in pooled human liver microsomes, and the most potent inhibitor identified was the leukotriene receptor antagonist, montelukast (IC50 = 19.6 nM). Inhibitors of CYP2C8 were identified from a wide variety of therapeutic classes, with no single class predominating. Other potent inhibitors included candesartan cilexetil (cyclohexylcarbonate ester prodrug of candesartan), zafirlukast, clotrimazole, felodipine, and mometasone furoate. Seventeen moderate inhibitors of rhCYP2C8 (1 < IC50 < 10 μM) included salmeterol, raloxifene, fenofibrate, ritonavir, levothyroxine, tamoxifen, loratadine, quercetin, oxybutynin, medroxyprogesterone, simvastatin, ketoconazole, ethinyl estradiol, spironolactone, lovastatin, nifedipine, and irbesartan. These in vitro data were used along with clinical pharmacokinetic information in predicting potential drug‐drug interactions that could occur by inhibition of CYP2C8. Although almost all drugs tested are not expected to cause drug interactions via inhibition of CYP2C8, montelukast was identified as being of concern as a potential inhibitor of clinical relevance. These findings are discussed in context to potential drug interactions that could be observed between these agents and drugs for which CYP2C8 is involved in metabolism and warrant investigation of the possibility of clinical drug interactions mediated by inhibition of this enzyme.
HEAD ACCELERATION DURING A SIMULATED MATCH LOAD OF TACKLES

This study aimed to determine the acceleration of the head relative to the thorax during rugby tackles and to examine the relationship between this acceleration and neck strength. Six statelevel rugby players were randomly paired and engaged in 15 repeated front-on tackles. High speed motion capture recorded head movement while neck strength was measured in an isokinetic dynamometer. Mean (SD) peak head acceleration for the ball carrier and tackler were 4.2g (±4.6) and 19.8g (±10.9) respectively. Correlation analyses showed the higher the flexion to extension neck strength ratio the lower the acceleration for the tackler only (r = 0.98). There is a much greater risk of being exposed to high accelerations of the head relative to the thorax for the tackler compared to the ball carrier. Further, minimising the strength difference between the neck flexors and extensors may have an effect of reducing head acceleration during a tackle.
Phagosome-lysosome interactions in cultured macrophages infected with virulent tubercle bacilli. Reversal of the usual nonfusion pattern and observations on bacterial survival

Tubercle bacilli of the pathogenic human strain H37Rv had previously been shown to multiply, after ingestion by cultured mouse peritoneal macrophages, within phagosomes that tended to remain unfused with secondary lysosomes. Means were sought therefore for promoting experimentally a modification of the host response so as to attain a high level of phagolysosome formation, enabling tests to be made of any effects on the course and outcome of the intracellular infection. This was achieved by exposing viable bacilli to specific rabbit antiserum before their ingestion. Quantitative assessments, using electron microscopy, now showed that a majority of the phagosomes containing intact bacilli had fused with ferritin-labeled lysosomes, and frequently the fusion was massive. Bacterial viability studies established that the serum pretreatment was not itsel bactericidal. In the course of progressive infections with strain H37Rv, monitored by counts both of viable bacterial units and of intracellular acid-fast organisms, no appreciable difference was found between the intracellular growth rates of control and antiserum-treated bacilli. Concurrent electron microscopy showed that bacilli could remain intact and multiply both in phaagolysosomes and in unfused phagosomes, ruling out the possibility of selective growth of antiserum-pretreated bacilli within the minority of phagosomes that remained unfused. It was concluded that "turning on" phagosome-lysosome fusion in normal macrophages did not influence the outcome of infection with virulent M. tuberculosis; lysosome contents manifestly failed to exercise an antibacterial effect on this organism. Nevertheless, the possibility remains that the lysosomes of specific immune macrophages have antituberculous potentiality. In that case the experimental "turning on or off" of fusion could be a decisive factor in the outcome of a virulent challenge. Should it not be, the antibacterial capabilities of immune cells would need to be ascribed to factors other than lysosomal attack, the latter being essentially for disposal of the dead organisms.
Multi-cell linear precoding design for throughput optimization with imperfect CSI and outage

Cooperative multi-cell MIMO techniques are well known for their outstanding capability to mitigate inter-cell interference by allowing user data to be jointly processed by several interfering base stations for the improvement of the system performance. This paper proposes an iterative algorithm that designs the precoding matrix for cooperative multi-cell MIMO downlink communications. As the demand for higher throughput and higher system resilience is envisioned for future wireless communication systems, the proposed algorithm takes the potential outage into consideration when channel state information is only partially available at the transmitter side. The aim is to maximize the sum user throughput considering outage with subject to power limitation at each base station. The joint optimization of the precoding matrix and the assigned transmission rate is solved via a 2-step alternating algorithm. The performance of the proposed method is evaluated by Monte Carlo simulations and compared with existing methods. Simulation results show that our proposed algorithm achieves performance gain than other referenced methods over the entire compared SNR region. Performance of all methods are also compared and analyzed when inter-cluster interference is present.
Antibiotic Exposure During the First 6 Months of Life and Weight Gain During Childhood.

IMPORTANCE Early-life antibiotic exposure has been associated with increased adiposity in animal models, mediated through the gut microbiome. Infant antibiotic exposure is common and often inappropriate. Studies of the association between infant antibiotics and childhood weight gain have reported inconsistent results. OBJECTIVE To assess the association between early-life antibiotic exposure and childhood weight gain. DESIGN AND SETTING Retrospective, longitudinal study of singleton births and matched longitudinal study of twin pairs conducted in a network of 30 pediatric primary care practices serving more than 200,000 children of diverse racial and socioeconomic backgrounds across Pennsylvania, New Jersey, and Delaware. PARTICIPANTS Children born between November 1, 2001, and December 31, 2011, at 35 weeks' gestational age or older, with birth weight of 2000 g or more and in the fifth percentile or higher for gestational age, and who had a preventive health visit within 14 days of life and at least 2 additional visits in the first year of life. Children with complex chronic conditions and those who received long-term antibiotics or multiple systemic corticosteroid prescriptions were excluded. We included 38,522 singleton children and 92 twins (46 matched pairs) discordant in antibiotic exposure. Final date of follow-up was December 31, 2012. EXPOSURE Systemic antibiotic use in the first 6 months of life. MAIN OUTCOMES AND MEASURES Weight, measured at preventive health visits from age 6 months through 7 years. RESULTS Of 38,522 singleton children (50% female; mean birth weight, 3.4 kg), 5287 (14%) were exposed to antibiotics during the first 6 months of life (at a mean age of 4.3 months). Antibiotic exposure was not significantly associated with rate of weight change (0.7%; 95% CI, -0.1% to 1.5%; P = .07, equivalent to approximately 0.05 kg; 95% CI, -0.004 to 0.11 kg of added weight gain between age 2 years and 5 years). Among 92 twins (38% female; mean birth weight, 2.8 kg), the 46 twins who were exposed to antibiotics during the first 6 months of life received them at a mean age of 4.5 months. Antibiotic exposure was not significantly associated with a weight difference (-0.09 kg; 95% CI, -0.26 to 0.08 kg; P = .30). CONCLUSIONS AND RELEVANCE Exposure to antibiotics within the first 6 months of life compared with no exposure was not associated with a statistically significant difference in weight gain through age 7 years. There are many reasons to limit antibiotic exposure in young, healthy children, but weight gain is likely not one of them.
2016+112: a gravitationally lensed type II quasar

A single-screen model of the gravitational lens system 2016+112 is proposed, that explains recent Hubble Space Telescope (HST) infrared (NICMOS-F160W) observations and new high-resolution European VLBI Network (EVN) 5-GHzradio observations, presented in this paper. In particular, we find that a massive 'dark' structure at the lens position, previously suggested by X-ray, optical and spectroscopic observations of the field around 2016+112, is not necessarily required to accommodate the strong-lensing constraints. A massive structure to the north-west of the lens system, suggested from a weak-lensing analysis of the field, is included in the model. The lensed source is an X-ray bright active galaxy at z = 3.273 with a central bright optical continuum core and strong narrow emission lines, suggestive of a type II quasar. The EVN 5-GHz radio maps show a radio jet structure with at least two compact subcomponents. We propose that the diamond caustic crosses the counter-jet of the radio source, so that part of the counter-jet, host galaxy and narrow-line emission regions are quadruply imaged. The remainder of the radio source, including the core, is doubly imaged. Our lens model predicts a very high magnification (μ ∼ 300) at the brightness peaks of the inner two radio components of complex C. If the jet exhibits relativistic velocities on microarsecond scales, it might result in apparent hyperluminal motion. However, the lack of strong radio variability and the peaked radio spectrum imply that these motions need not be present in the source. Our model furthermore implies that the optical spectrum of C' can only show features of the active galactic nuclei and its host galaxy.
Mars Initial Reference Ionosphere (MIRI) Model: Updates and Validations Using MAVEN, MEX, and MRO Data Sets

The Mars Initial Reference Ionosphere (MIRI) model is a semiempirical formulation designed to provide climatological estimates of key parameters of the Martian ionosphere. For the new MIRI‐2018 version, an expanded database is used from the Mars Express/Mars Advanced Radar for Subsurface and Ionosphere Sounding/Active Ionospheric Sounding (MEX/MARSIS/AIS) instrument, consisting of 215,818 values of maximum electron density of the M2‐layer (NmM2) from the years 2005–2015. These data are organized by photochemical‐equilibrium equations to obtain a functional dependence of NmM2 upon solar drivers (flux and solar zenith angle). The resulting peak density is used to calibrate normalized electron density profiles [Ne (h)] derived from theory and an empirical model. The MIRI‐2018 thus provides estimates of NmM2, Ne (h), and total electron content (TEC) for any date past or future. Validation using Mars Atmosphere and Volatile EvolutioN (MAVEN)'s new radio occultation science experiment (ROSE) was successful for NmM2 values, but MIRI was found to overestimate TEC values. The validation failure for TEC was traced to overestimates of plasma at low altitudes (M1 layer). A separate module for TEC was derived using 126,055 values from the Mars Reconnaissance Orbiter/SHAllow RADar (MRO/SHARAD) TEC database from 2006 to 2014. Validation of this new TEC module with ROSE data was successful. Future improvements to MIRI‐2018 require new ways to characterize the bottomside ionosphere's contribution to the TEC integral for midday (low solar zenith angle) conditions. This requires new simulation studies of secondary ionization rates by photoelectrons produced via the primary X‐ray ionization process for the M1 layer.
Disease activity and cancer risk in inflammatory bowel disease associated with primary sclerosing cholangitis.

AIM To investigate the phenotype of inflammatory bowel disease associated with primary sclerosing cholangitis (PSC-IBD). METHODS Data from 75 PSC-IBD patients evaluated in our tertiary center between 1963 and 2006 were collected and compared to 150 IBD patients without PSC, matched for sex, birth date, IBD diagnosis date and initial disease location regarding ileal, different colonic segments, and rectum, respectively. RESULTS While PSC-IBD patients received more 5-aminosalicylates (8.7 years/patient vs 2.9 years/patient, P < 0.001), they required less immuno-suppressors (24% vs 46% at 10 years; P < 0.001) and less intestinal resection (10% vs 44% at 10 years, P < 0.001). The 25-year cumulative rate of colectomy was 25.1% in PSC-IBD and 37.3% in controls (P = 0.004). The 25-year cumulative rate of colorectal cancer was 23.4% in PSC-IBD vs 0% in controls (P = 0.002). PSC was the only independent risk factor for the development of colorectal cancer (OR = 10.8; 95% CI, 3.7-31.3). Overall survival rate without liver transplantation was reduced in PSC-IBD patients (67% vs 91% in controls at 25 years, P = 0.001). CONCLUSION This study confirms that patients with PSC-IBD have a particular disease phenotype independent of the initial disease location. Although their disease is less active and they use more 5-aminosalicylates, they present a higher risk of colorectal cancer.
Human Dorsal Striatum Encodes Prediction Errors during Observational Learning of Instrumental Actions

The dorsal striatum plays a key role in the learning and expression of instrumental reward associations that are acquired through direct experience. However, not all learning about instrumental actions require direct experience. Instead, humans and other animals are also capable of acquiring instrumental actions by observing the experiences of others. In this study, we investigated the extent to which human dorsal striatum is involved in observational as well as experiential instrumental reward learning. Human participants were scanned with fMRI while they observed a confederate over a live video performing an instrumental conditioning task to obtain liquid juice rewards. Participants also performed a similar instrumental task for their own rewards. Using a computational model-based analysis, we found reward prediction errors in the dorsal striatum not only during the experiential learning condition but also during observational learning. These results suggest a key role for the dorsal striatum in learning instrumental associations, even when those associations are acquired purely by observing others.
Quality of life after total laryngectomy: functioning, psychological well-being and self-efficacy.

BACKGROUND Quality of life (QoL) is an important construct when assessing treatment outcomes. AIMS To examine the relative contributions of functioning, psychological well-being and self-efficacy on self-perceived QoL with a sample of total laryngectomy patients in Australia who had surgery for advanced laryngeal cancer. METHODS & PROCEDURES In a cross-sectional study, 113 members of the Laryngectomy Associations of New South Wales and of Victoria, Australia, were recruited, and each was sent a series of questionnaires for postal return. Four psychometrically validated measures were used for participants to document their QoL, functioning (speech, swallowing), psychological well-being and general self-efficacy. OUTCOMES & RESULTS Eighty-six (77%) questionnaires were returned and 83 were analysed. The cohort consists of 70 men and 13 women aged between 46 and 88 years. Overall, this sample of total laryngectomy survivors demonstrated significantly reduced physical health QoL (p < 0.001) and social relationship QoL (p = 0.011) and higher levels of depression (p = 0.008) and anxiety (p = 0.001) when compared with normative samples. This was in the context of them having higher than normal self-efficacy scores and, at worst, mild (self-rated) impairment of speech and of swallowing. Psychological well-being (sr(2) = 0.43, p < 0.001) had a stronger association than functioning (speech, swallowing, sr(2) = 0.08, p < 0.05) for their psychological QoL. Psychological well-being (sr(2) = 0.17, p < 0.001) and not functioning (sr(2) = 0.05, p > 0.05) were significantly associated with social relationship QoL. Self-efficacy scores were significantly higher than norms in this cohort, but were not associated with either their psychological QoL or social relationship QoL, after controlling for psychological well-being and functioning. CONCLUSIONS & IMPLICATIONS For survivors of laryngeal cancer treated by total laryngectomy, it is important to be aware of the impact of psychological well-being (depression, anxiety, stress) on self-perceived QoL. In addition to rehabilitating function (speech, swallowing), specific interventions to assist these individuals better manage their psychological well-being will likely improve their perceived life satisfaction/QoL.
Retinal nerve fibre layer detection in fundus camera images compared to results from optical coherence tomography

Two approaches to evaluation of the retinal nerve fibre layer (RNFL) status are compared in the contribution: detection of the local existence of the RNFL in the fundus camera (FC) images versus the objective measurement of the RNFL thickness at identical retinal locations by the optical coherence tomography (OCT). The local detection results based on a compound texture analysis in FC images were compared with the objective OCT measurements considered a contemporary gulden standard, after precisely registering the image data from both modalities. The contribution shows that the reliability of the textural detection in FC images is rather high, reaching the specificity 88.9 % and sensitivity 88.6 % on the so far available material of pairs of FC images and corresponding OCT measurements. The comparison shows the feasibility of the cheap FC image based approach suitable particularly also for screening purposes.
A prospective study of psychological distress among mothers of children admitted to a nutritional rehabilitation unit in Malawi.

OBJECTIVES Accompanying guardians (usually the mother) have a pivotal role in promoting recovery from childhood severe acute malnutrition on Nutritional Rehabilitation Units (NRUs). We describe the prevalence of maternal distress at an NRU in Malawi and identify factors associated with this. We tested the hypothesis that maternal distress during admission would be associated with reduced child weight gain over the 4-week post-discharge period. METHODS Maternal distress was measured using the Self Reporting Questionnaire (SRQ) administered to mothers of consecutive children during NRU admission. Repeat SRQ was administered to mothers attending a follow-up clinic 4 weeks post discharge. Maternal, child and psychosocial variables were also measured. Child weight change from discharge to follow-up was compared between children of mothers scoring SRQ ≥ 8 and those scoring SRQ < 8. FINDINGS A total of 244 mothers and their children were recruited. In total, 71% of mothers scored SRQ ≥ 8 during admission. In all, 155 of 222 mothers eligible to complete repeat SRQ did so, and 33.5% scored SRQ ≥ 8. Maternal distress at recruitment was associated with older child age, no confiding relationship with spouse, having had a previous child die, and the child having diarrhoea. Maternal distress at follow-up was associated with older child age, the child having diarrhoea or fever since discharge, and the child being HIV sero-positive. Maternal distress during admission was not associated with child weight gain at 4-week post-discharge follow-up. CONCLUSION Levels of maternal distress are very high during child admission to an NRU. Persistent distress is associated with child health factors including HIV. Nutritional rehabilitation programmes should pay increased attention to carer psychological wellbeing using targeted evidence-based interventions.