Miracle-dz/UniFAR-FTUs huggingface dataset:
Temporal shifts and temperature sensitivity of avian spring migratory phenology: a phylogenetic meta‐analysis

Summary There are wide reports of advances in the timing of spring migration of birds over time and in relation to rising temperatures, though phenological responses vary substantially within and among species. An understanding of the ecological, life‐history and geographic variables that predict this intra‐ and interspecific variation can guide our projections of how populations and species are likely to respond to future climate change. Here, we conduct phylogenetic meta‐analyses addressing slope estimates of the timing of avian spring migration regressed on (i) year and (ii) temperature, representing a total of 413 species across five continents. We take into account slope estimation error and examine phylogenetic, ecological and geographic predictors of intra‐ and interspecific variation. We confirm earlier findings that on average birds have significantly advanced their spring migration time by 2·1 days per decade and 1·2 days °C−1. We find that over time and in response to warmer spring conditions, short‐distance migrants have advanced spring migratory phenology by more than long‐distance migrants. We also find that larger bodied species show greater advance over time compared to smaller bodied species. Our results did not reveal any evidence that interspecific variation in migration response is predictable on the basis of species' habitat or diet. We detected a substantial phylogenetic signal in migration time in response to both year and temperature, suggesting that some of the shifts in migratory phenological response to climate are predictable on the basis of phylogeny. However, we estimate high levels of species and spatial variance relative to phylogenetic variance, which is consistent with plasticity in response to climate evolving fairly rapidly and being more influenced by adaptation to current local climate than by common descent. On average, avian spring migration times have advanced over time and as spring has become warmer. While we are able to identify predictors that explain some of the true among‐species variation in response, substantial intra‐ and interspecific variation in migratory response remains to be explained.
Exploring Reproductive Coercion in Relationship Contexts Among Young Adult, Primarily African American Women at Three Women’s Health Clinics

Understanding reproductive coercion experiences in marginalized populations is important to assist in tailoring care and services. Reproductive coercion is consistently associated with intimate partner violence (IPV), engaging in sexual risk-taking, and is more commonly reported among non-White women. We conducted a secondary analysis of data from a mixed methods study to examine reproductive coercion in relationship contexts among a sample (N = 130) of young adult, primarily African American women recruited from three women’s health clinics; 12 also participated in an in-depth interview. Thirty-six women (27.7%) reported reproductive coercion in the past year. Past-year reproductive coercion was associated with relationship trust, (t(128) = −3.01, p = . 003), and past-year IPV (Fisher’s exact test, p = .005). In the best-fit model, odds of past-year reproductive coercion increased by 4% with each one-point increase in relationship trust score (indicating reproductive coercion increased with lower trust; adjusted odds ratio [AOR] = 1.04; 95% confidence interval [CI] = [1.00, 1.08]), and by more than 4 times with past experience of IPV (AOR = 4.74; 95% CI = [1.07, 20.86]). Qualitative analysis revealed women’s awareness of reproductive coercion whether or not they personally experienced it. Those who experienced reproductive coercion identified it as a form of abuse and additionally described experiences of pressure to conceive from the partner’s family. Our results support routine screening for IPV and reproductive coercion. Furthermore, the intersection of partner reproductive coercion with family pressure related to reproductive decision making should be explored to better inform clinical interventions.
Systematic Review of School-Based Interventions to Modify Dietary Behavior: Does Intervention Intensity Impact Effectiveness?

BACKGROUND Owing to the associations between diet and health, it is important that effective health promotion strategies establish healthful eating behaviors from an early age. We reviewed the intensity of school-based interventions aimed to modify dietary behavior in preadolescent and adolescents and related intervention characteristics to effectiveness. METHODS Our systematic literature search of 8 databases sought to identify interventions measuring dietary intake in school settings to students aged 9 to 18. We evaluated these studies for effectiveness, intensity, intervention category, and follow-up measures. RESULTS Of the 105 interventions 81 were found to be effective immediately postintervention, irrespective of intensity. Studies that were 6 weeks to 5 months in duration, targeted students' environment or group (alone or in combination), and reached students only in schools were more effective. Only one-fifth of interventions conducted a follow-up measure, and a majority showed a loss of effectiveness from postintervention to follow-up. CONCLUSIONS We identified characteristics of effective interventions. These findings may inform the development of future interventions targeting dietary behavior in preadolescents and adolescents in the school-based setting.
Are saddles good enough for neural networks

Recent years have seen a growing interest in understanding neural networks from an optimization perspective. It is understood now that converging to low-cost local minima is sufficient for such models to become effective in practice. However, in this work, we propose a new hypothesis based on recent theoretical findings and empirical studies that neural network models actually converge to saddle points with high degeneracy. Our findings from this work are new, and can have a significant impact on the development of gradient descent based methods for training neural networks. We validated our hypotheses using an extensive experimental evaluation on standard datasets such as MNIST and CIFAR-10, and also showed that recent efforts that attempt to escape saddles finally converge to saddles with high degeneracy, which we define as 'good saddles'. We also verified the famous Wigner's Semicircle Law in our experimental results.
Multi-Area Dynamic State Estimation With PMU Measurements by an Equality Constrained Extended Kalman Filter

To achieve higher accuracy of estimated dynamic states, phasor measurement unit (PMU) measurements of buses in a network can be used for dynamic state estimation (DSE). However, it is difficult to coordinate the states of boundary buses in different areas when performing multiarea DSE. By using PMU measurements of buses in the network, this paper proposes an extended Kalman filter-based method with equality constraints to conduct multi-area DSE. First, a corrective strategy is proposed to estimate a corrective internal voltage (CIV) and a corrective rotor angle (CRA) of each generator with all PMUs’ measurements. The proposed corrective strategy can also ensure the consistency of the boundary buses in the multiareas. Then, the CIV and the CRA are used to establish equality constraints for updating the dynamic states with the PMU measurements. An IEEE 30-bus system and an IEEE 118-bus system are used to validate the proposed method, with the results showing the feasibility and accuracy of the proposed method.
7q Deletion/12q Duplication Is the Possible Cause of an Alobar Holoprosencephaly Case

Holoprosencephaly (HPE) spectrum disorder is the most common congenital malformation of the human brain with absence of or incomplete midline cleavage. Its cause is heterogenic, making genetic counseling a challenge. In this case report, a pregnancy affected by alobar HPE is described. Using aCGH, an 8.9-Mb deletion at 7q36.1q36. 3 together with a 4.9-Mb duplication at 12q24.32q24. 33 is assumed to be the possible reason for this alobar HPE case. It is discussed that disruption of key elements of the developing brain, taking environmental factors into account, contributes to the HPE spectrum. The use of aCGH for invasive prenatal testing is starting to become the standard technique, providing accurate information about the cause of congenital diseases for couples receiving genetic counseling.
Recruitment of UvrBC complexes to UV-induced damage in the absence of UvrA increases cell survival

Abstract Nucleotide excision repair (NER) is the primary mechanism for removal of ultraviolet light (UV)-induced DNA photoproducts and is mechanistically conserved across all kingdoms of life. Bacterial NER involves damage recognition by UvrA2 and UvrB, followed by UvrC-mediated incision either side of the lesion. Here, using a combination of in vitro and in vivo single-molecule studies we show that a UvrBC complex is capable of lesion identification in the absence of UvrA. Single-molecule analysis of eGFP-labelled UvrB and UvrC in living cells showed that UV damage caused these proteins to switch from cytoplasmic diffusion to stable complexes on DNA. Surprisingly, ectopic expression of UvrC in a uvrA deleted strain increased UV survival. These data provide evidence for a previously unrealized mechanism of survival that can occur through direct lesion recognition by a UvrBC complex.
Structure–electrical conductivity of polyvinylidene fluoride/graphite composites

Graphite powder was introduced into polyvinylidene fluoride via the solution mixing technique. The composites were then subjected to hot compression molding. The effect of dispersion of graphite particles and electrical conductivity of the composites were investigated. Solution mixing enabled homogeneous dispersion of graphite powder within the polyvinylidene fluoride matrix as revealed by transmission electron microscopy. X-ray diffraction and Fourier transform infrared spectroscopy analysis revealed that graphite incorporation induced the α-phase of polyvinylidene fluoride. The DC conductivity results showed that the conductivity increased with an increase in graphite content. Beyond a critical concentration of graphite, percolation threshold, (Φ c = 2.3 vol%) the conductivity increases by five orders of magnitude at 3.9 vol% of graphite powder composite. The electrical conductivity was approximately constant for the composites with the higher graphite loading. Consequently, adding more graphite powder did not significantly alter the electrical conductivity. The correlation between the dispersion of graphite particles and electrical conductivity was discussed. The AC conductivity of composites was investigated in a wide range of frequencies from 50 Hz to 5 MHz and at temperatures ranging from room temperature to 180°C. The conductivity of the composites exhibited strong frequency dependence particularly in the vicinity of the electrical percolation threshold. σAC obeyed the power law of the form: σ AC = A ( T ) · ω S ( T ) , where ω is the angular frequency and s and A the characteristic parameters. The values of the exponent (s) were found to decrease with increasing temperature which is consistent with the correlated barrier-hopping model.
Feedback processing in adolescents with prenatal cocaine exposure: an electrophysiological investigation

ABSTRACT Impaired cognitive control is a consequence of cocaine exposure. Difficulty with feedback processing may underlie this impairment. We examined neural correlates of feedback processing using event-related potentials (ERPs) in 49 prenatally cocaine-exposed (PCE) and 34 nondrug exposed (NDE) adolescents. Adolescents performed a reward-feedback task with win/no-win feedback in a chance-based task. We investigated amplitude and latency of the feedback-related negativity (FRN) and P300 ERP components and source-based estimates elicited during feedback processing. PCE adolescents had smaller P300 amplitudes for no-win feedback, and source analysis in the P300 time window revealed differences between groups localized to the dorsal anterior cingulate cortex.
Evaluation of the Cytosorb™ Hemoadsorptive Column in a PIG Model of Severe Smoke and Burn Injury

Introduction: Host inflammatory response to any form of tissue injury, including burn, trauma, or shock, has been well documented. After significant burns, cytokines can increase substantially within the first 24 h after injury and may contribute to subsequent organ failure. Hemoadsorption by cytokine-adsorbing columns may attenuate this maladaptive response, thereby improving outcomes. The aim of this study was to investigate the feasibility, technical safety, and efficacy of cytokine and myoglobin removal by early use of a cytokine absorbing column (CytoSorb) in a porcine model of smoke inhalation and burn injury. Methods: Anesthetized female Yorkshire pigs (n = 15) were injured by wood bark smoke inhalation and a 40% total body surface area deep burn and observed for 72 h or death. The animals were randomized to hemoadsorption treatment (n = 9) or a sham group (n = 6) before injury. A 6-h hemoadsorption or sham session was performed on days one, two, and three. Serum cytokines (IL-1b, IL-6, IL-8, IL-10, TNF-alpha) and myoglobin were measured systemically, locally in bronchoalveolar lavage fluid and also in circulating blood before and after the adsorbing column to evaluate single pass clearance by the device. Results: Hemoadsorption caused significant removal of IL-1b, IL-6, IL-10, and myoglobin across the device mainly during the first run, ranging from 22% for IL-6 to 29% for IL-1b and 41% removal rates for myoglobin after 15 min of treatment. Systemic cytokine or myoglobin serum concentrations did not change. Conclusions: In a porcine model of smoke and burn injury, hemoadsorption using the CytoSorb cartridge did not result in significant systemic or pulmonary reductions in the measured cytokines or myoglobin despite efficient transmembrane reductions. Further investigations are needed to optimize the efficiency of mediator clearance to affect both circulating levels and clinically relevant outcomes.
Surface Quasi-Geostrophy

Oceanic and atmospheric dynamics are often interpreted through potential vorticity, as this quantity is conserved along the geostrophic flow. However, in addition to potential vorticity, surface buoyancy is a conserved quantity, and this also affects the dynamics. Buoyancy at the ocean surface or at the atmospheric tropopause plays the same role of an active tracer as potential vorticity does since the velocity field can be deduced from these quantities. The surface quasi-geostrophic model has been proposed to explain the dynamics associated with surface buoyancy conservation and seems appealing for both the ocean and the atmosphere. In this review, we present its main characteristics in terms of coherent structures, instabilities and turbulent cascades. Furthermore, this model is mathematically studied for the possible formation of singularities, as it presents some analogies with three-dimensional Euler equations. Finally, we discuss its relevance for the ocean and the atmosphere.
The prognostic value of clonal heterogeneity and quantitative assessment of plasma circulating clonal IG-VDJ sequences at diagnosis in patients with follicular lymphoma

Recent advances in next-generation sequencing (NGS) have enabled the quantitation of circulating tumour DNA (ctDNA) encoding the clonal rearranged V(D)J immunoglobulin locus. We aimed to evaluate the clonal heterogeneity of follicular lymphoma (FL) in the tumour and the plasma at diagnosis and to assess the prognostic value of the ctDNA level. Plasma samples at diagnosis were available for 34 patients registered in the PRIMA trial (NCT00140582). One tumour clonotype or more could be detected for 29 (85%) and 25 (74%) patients, respectively, in the tumour or plasma samples. In 18 patients, several subclones were detected in the tumour (2 to 71 subclones/cases) and/or in the plasma (2 to 20 subclones/cases). In more than half of the cases, the distribution of subclones differed between the tumour and plasma samples, reflecting high clonal heterogeneity and diversity in lymphoma subclone dissemination. In multivariate analysis, a high level of ctDNA was the only independent factor associated with patients’ progression-free survival (HR 4, IC 95 (1.1-37), p=. 039). In conclusion, an NGS-based immunosequencing method reveals the marked clonal heterogeneity of follicular lymphoma in patients with FL, and quantification of ctDNA at diagnosis represents a potential powerful prognostic biomarker that needs to be investigated in larger cohorts.
Bacterial Nanocellulose as a Renewable Material for Biomedical Applications

Nanocellulose, such as that produced by the bacteria Gluconacetobacter xylinus (bacterial cellulose, BC), is an emerging biomaterial with great potential as a biological implant, wound and burn dressing material, and scaffolds for tissue regeneration. BC has remarkable mechanical properties despite the fact that it contains up to 99% water. The water-holding ability is the most probable reason why BC implants do not elicit any foreign body reaction. Moreover, the nanostructure and morphological similarities with collagen make BC attractive for cell immobilization and cell support. The architecture of BC materials can be engineered over length scales ranging from nano to macro by controlling the biofabrication process. This article describes current and future applications of BC in the biomedical field.
Frequency and Methods of Nonsuicidal Self-Injury in Relation to Acquired Capability for Suicide Among Adolescents

The objective of this study was to test the Interpersonal Psychological Theory of Suicide (IPTS) proposal that the association of nonsuicidal self-injury (NSSI) with suicide attempt is mediated by acquired capability. Inpatient adolescents (n = 134) reported on suicide ideation and attempts, NSSI frequency and methods, depressive symptoms, and acquired capability for suicide. Consistent with the IPTS, both measures of NSSI were positively associated with acquired capability after accounting for depressive symptoms and past history of attempts. However, both NSSI measures explained independent variance in number of suicide attempts after controlling for suicide ideation and acquired capability. These findings contradict the IPTS and suggest that the role of NSSI in suicide attempt is mediated by variables external to the IPTS.
MIBI scintigraphy of parathyroid adenomas: correlation with biochemical and histological markers

ABSTRACT Purpose: In this study, we tested the hypothesis that MIBI-positive and MIBI-negative adenomas of parathyroid glands (APGs) have distinct biochemical and histological markers that could help differentiate MIBI-positive from MIBI-negative APGs. Patients and methods: 40 patients with 41 APGs were included in the study. Patients were enrolled in the study after MIBI scintigraphy examinations had been carried out. Biochemical analyses included serum levels of calcium (Ca), intact parathyroid hormone (iPTH), and 25-hydroxyvitamin D3 (25-OH-D3). All patients had neck ultrasound and MIBI examinations. After surgical resection the APGs were examined histologically. Results: In each of 39 patients one APG could be confirmed by histology, and in one patient, two contralateral APGs were identified. MIBI studies were positive in 73 % and negative in 27 % of the APGs. False-positive cases were not observed. MIBI-negative APGs were only present in patients with iPTH values below 150 pg/ml. In 82 % of MIBI negative studies oxyphilic cells were absent, and this cell type was present in only 18 % of MIBI negative cases (p < 0.001). Regarding cysts within the APGs, no differences were demonstrated between MIBI positive or negative studies (p = 0.32). Fat cells were seen in none of the MIBI -negative studies and in only 3 % of MIBI positive studies (p = 0.08). Conclusions: For APGs, MIBI positivity correlates with serum iPTH concentration. The absence of oxyphilic cells with large numbers of mitochondria in APGs contributes to MIBI negativity, probably because of the reduced binding sites for the radiotracer.
An Empirical Study on the Interaction Capability of Arm Stretching

ABSTRACT Body-based motion gestures have been gaining popularity in designing interactive systems. However, theories and design guidelines on the use of body movement in design have not been fully evaluated. This article investigates human ability to perform discrete target selection tasks using stretching action through two controlled experiments. The experimental results indicate that: (1) the range of the discrete levels of depth that users can easily discriminate with arm stretching is up to 16 with full visual feedback, but is down to 4 without the feedback; (2) dwelling, a gesture with keeping a hand motionless and the cursor within a target area for a certain amount of time, may be the best gesture for confirmation command; (3) full visual feedback can improve the user performance; and (4) arm stretching action can be modeled using Fitts’ law. We also discuss the design potentials for Stretch Widgets based on these results.
Treatment with Atorvastatin Provides Additional Benefits to Imipenem in a Model of Gram-Negative Pneumonia Induced by Klebsiella pneumoniae in Mice

ABSTRACT The clinical pathogen Klebsiella pneumoniae is a relevant cause of nosocomial infections, and resistance to current treatment with carbapenem antibiotics is becoming a significant problem. Statins are inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) used for controlling plasma cholesterol levels. There is clinical evidence showing other effects of statins, including decrease of lung inflammation. In the current study, we show that pretreatment with atorvastatin markedly attenuated lung injury, which was correlated with a reduction in the cellular influx into the alveolar space and lungs and downmodulation of the production of proinflammatory mediators in the initial phase of infection in C57BL/6 mice with K. pneumoniae. However, atorvastatin did not alter the number of bacteria in the lungs and blood of infected mice, despite decreasing local inflammatory response. Interestingly, mice that received combined treatment with atorvastatin and imipenem displayed better survival than mice treated with vehicle, atorvastatin, or imipenem alone. These findings suggest that atorvastatin could be an adjuvant in host-directed therapies for multidrug-resistant K. pneumoniae, based on its powerful pleiotropic immunomodulatory effects. Together with antimicrobial approaches, combination therapy with anti-inflammatory compounds could improve the efficiency of therapy during acute lung infections.