Miracle-dz/UniFAR-FTUs huggingface dataset:
Single‐shot diffusion MRI of human brain on a conventional clinical instrument

A single‐shot diffusion MRI technique on a standard clinical 1.5T scanner is presented. The method incorporates the following elements: (a) an inversion RF pulse followed by a delay of 1.3 s to null cerebral spinal fluid (CSF) signal, (b) a stimulated echo sequence (TE=56 ms, TM=100 ms) to obtain strong diffusion weighting, (c) a single‐shot gradient‐ and spin‐echo (GRASE) sequence for imaging with a modified k‐space trajectory and Carr‐Purcell Meiboom‐Gill (CPMG)‐phase cycle. The trace of the diffusion coefficient obtained with this approach is in good agreement with values reported for animal brain, and for recent human studies. It is demonstrated that single‐shot diffusion imaging of human brain is feasible on an unmodified standard instrument without high‐gradient slew rate or extreme field homogeneity.
Politics, stock markets, and model uncertainty

The available evidence on the effects of political variables on both returns and volatility of aggregate stock indices is scant and mixed. Applying Bayesian Model Averaging to a panel dataset of 17 parliamentary democracies spanning the post-war period until 1995, we test the robustness of political variables in explaining stock returns and stock return volatility. While we find that the influence of political variables on excess returns is weak, there is evidence of some political variables explaining return volatility.
Harmonic Analysis of the Fluorescence Response of Bimane Adducts of Colicin E1 at Helices 6, 7, and 10*

Background: Colicin E1 forms a voltage-dependent channel in the cytoplasmic membrane of target E. coli cells. Results: Fluorescence analyses reveal that helices 6, 7, and 10 in the membrane-bound colicin E1 are separate amphipathic α-helices with different periodicities. Conclusion: A new model of the closed channel of colicin E1 has been developed. Significance: This study provides new data on the structure of the umbrella model for the channel-forming colicins. The pre-channel state of helices 6, 7, and 10 (Val447–Gly475 and Ile508–Ile522) of colicin E1 was investigated by a site-directed fluorescence labeling technique. A total of 44 cysteine variants were purified and covalently labeled with monobromobimane fluorescent probe. A variety of fluorescence properties of the bimane fluorophore were measured for both the soluble and membrane-bound states of the channel peptide, including the fluorescence emission maximum, fluorescence anisotropy, and membrane bilayer penetration depth. Using site-directed fluorescence labeling combined with our novel helical periodicity analysis method, the data revealed that helices 6, 7, and 10 are separate amphipathic α-helices with a calculated periodicity of T = 3.34 ± 0.08 for helix 6, T = 3.56 ± 0.03 for helix 7, and T = 2.99 ± 0.12 for helix 10 in the soluble state. In the membrane-bound state, the helical periodicity was determined to be T = 3.00 ± 0.15 for helix 6, T = 3.68 ± 0.03 for helix 7, and T = 3.47 ± 0.04 for helix 10. Dual fluorescence quencher analysis showed that both helices 6 and 7 adopt a tilted topology that correlates well with the analysis based on the fluorescence anisotropy profile. These data provide further support for the umbrella model of the colicin E1 channel domain.
A Computerized Alert Screening For Severe Sepsis In Emergency Department Patients Increases Lactate Testing But Does Not Improve Inpatient Mortality

Summary Objective: This study tested the hypothesis that lactate testing in ED sepsis patients could be increased using a computer alert that automatically recognizes systemic inflammatory response syndrome (SIRS) criteria and recommends lactate testing in cases of sepsis defined as ≥2 SIRS criteria plus physician suspicion of infection. Secondary outcomes included the effect of the alert on lactate testing among admitted sepsis patients, the proportion of admitted patients with lactate ≥4.0 mmol/L identified and the in-patient mortality difference before and after alert implementation. Methods: After a 6 month pre-alert phase, a computer alert was implemented that computed and displayed abnormal vital signs and white blood cell counts for all patients with >2 SIRS criteria and recommended testing lactate if an infection was suspected. Data for admitted patients was collected electronically on consecutive patients meeting sepsis criteria for 6 months before and 6 months after implementation of the alert. Results: There were a total of 5,796 subjects enrolled. Among all septic patients, lactate testing increased from 5.2% in the pre-alert phase to 12.7% in the alert phase, a 7.5% (95% CI 6.0 to 9.0%) absolute increase in lactate testing, p<0.001. Among the 1,798 admitted patients with sepsis, lactate testing increased from 15.3% to 34.2%, an 18.9% (95% CI 15.0 to 22.8%) absolute increase, p<0.001. Among admitted patients with sepsis, there was a 1.9% (95% CI 0.03 to 3.8%, p = 0.05) increase in absolute number of patients with elevated lactate levels identified and a 0.5% (95% CI -1.6 to 2.6%, p=0.64) decrease in mortality. Conclusion: The proportion of ED patients who had lactate tested and the number of admitted patients identified with a lactate level ≥4.0 mmol/L improved significantly after the implementation of a computer alert identifying sepsis patients with >2 SIRS criteria while mortality among admitted sepsis patients remained unchanged.
Detecting Disagreement in Conversations using Pseudo-Monologic Rhetorical Structure

Casual online forums such as Reddit, Slashdot and Digg, are continuing to increase in popularity as a means of communication. Detecting disagreement in this domain is a considerable challenge. Many topics are unique to the conversation on the forum, and the appearance of disagreement may be much more subtle than on political blogs or social media sites such as twitter. In this analysis we present a crowd-sourced annotated corpus for topic level disagreement detection in Slashdot, showing that disagreement detection in this domain is difficult even for humans. We then proceed to show that a new set of features determined from the rhetorical structure of the conversation significantly improves the performance on disagreement detection over a baseline consisting of unigram/bigram features, discourse markers, structural features and meta-post features.
Tectono‐stratigraphic response of the Sandino Forearc Basin (N‐Costa Rica and W‐Nicaragua) to episodes of rough crust and oblique subduction

The southern Central American active margin is a world‐class site where past and present subduction processes have been extensively studied. Tectonic erosion/accretion and oblique/orthogonal subduction are thought to alternate in space and time along the Middle American Trench. These processes may cause various responses in the upper plate, such as uplift/subsidence, deformation, and volcanic arc migration/shut‐off. We present an updated stratigraphic framework of the Late Cretaceous–Cenozoic Sandino Forearc Basin (SFB) which provides evidence of sedimentary response to tectonic events. Since its inception, the basin was predominantly filled with deep‐water volcaniclastic deposits. In contrast, shallow‐water deposits appeared episodically in the basin record and are considered as tectonic event markers. The SFB stretches for about 300 km and varies in thickness from 5 km (southern part) to about 16 km (northern part). The drastic, along‐basin, thickness variation appears to be the result of (1) differential tectonic evolutions and (2) differential rates of sediment supply. (1) The northern SFB did not experience major tectonic events. In contrast, the reduced thickness of the southern SFB (5 km) is the result of at least four uplift phases related to the collision/accretion of bathymetric reliefs on the incoming plate: (i) the accretion of a buoyant oceanic plateau (Nicoya Complex) during the middle Campanian; (ii) the collision of an oceanic plateau (? ) during the late Danian–Selandian; (iii) the collision/accretion of seamounts during the late Eocene–early Oligocene; (iv) the collision of seamounts and ridges during the Pliocene–Holocene. (2) The northwestward thickening of the SFB may have been enhanced by high sediment supply in the Fonseca Gulf area which reflects sourcing from wide, high relief drainage basins. In contrast, sedimentary input has possibly been lower along the southern SFB, due to the proximity of the narrow, lowland isthmus of southern Central America. Moreover, two phases of strongly oblique subduction affected the margin, producing strike‐slip faulting in the forearc basin: (1) prior to the Farallon Plate breakup, an Oligocene transpressional phase caused deformation and uplift of the basin depocenter, triggering shallowing‐upward of the Nicaraguan Isthmus in the central and northern SFB; (2) a Pleistocene–Holocene transtensional phase drives the NW‐directed motion of a forearc sliver and reactivation of the graben‐bounding faults of the late Neogene Nicaraguan Depression. We discuss arguments in favour of a Pliocene development of the Nicaraguan Depression and propose that the Nicaraguan Isthmus, which is the apparent rift shoulder of the depression, represents a structure inherited from the Oligocene transpressional phase.
Maximizing Availability: A Commitment Heuristic for Oversubscribed Scheduling Problems

In this paper we reconsider a "task-swapping" procedure for improving schedules in the face of resource oversubscription. Prior work has demonstrated that use of a retraction heuristic to determine which tasks to rearrange in an existing schedule allows for addition of new tasks which would otherwise fail to be scheduled. The existing task swap procedure employs a variable ordering heuristic for task insertion that is the same as the retraction heuristic, but scored in the reverse. That is, the least constrained tasks are retracted, and of these the most constrained are committed first. Value selection for commitment is defaulted to a task's earliest feasible start time. We have found that by applying a value selection heuristic, max-availability, to the choice of where to assign the retracted tasks, both solution quality and runtime performance of task swap can be improved greatly. Max-availability considers resource contention for an unassigned task and places it where availability is predicted to be maximal over the range of that task. This heuristic is applicable not only in a repair context, but can also promote resource levelling in the context of constructive task allocation. Finally, we show that use of max-availability in task swapping promotes schedule stability when compared to the prior greedy task insertion policy.
Segmentation of Choroidal Boundary in Enhanced Depth Imaging OCTs Using a Multiresolution Texture Based Modeling in Graph Cuts

The introduction of enhanced depth imaging optical coherence tomography (EDI-OCT) has provided the advantage of in vivo cross-sectional imaging of the choroid, similar to the retina, with standard commercially available spectral domain (SD) OCT machines. A texture-based algorithm is introduced in this paper for fully automatic segmentation of choroidal images obtained from an EDI system of Heidelberg 3D OCT Spectralis. Dynamic programming is utilized to determine the location of the retinal pigment epithelium (RPE). Bruch's membrane (BM) (the blood-retina barrier which separates the RPE cells of the retina from the choroid) can be segmented by searching for the pixels with the biggest gradient value below the RPE. Furthermore, a novel method is proposed to segment the choroid-sclera interface (CSI), which employs the wavelet based features to construct a Gaussian mixture model (GMM). The model is then used in a graph cut for segmentation of the choroidal boundary. The proposed algorithm is tested on 100 EDI OCTs and is compared with manual segmentation. The results showed an unsigned error of 2.48 ± 0.32 pixels for BM extraction and 9.79 ± 3.29 pixels for choroid detection. It implies significant improvement of the proposed method over other approaches like k-means and graph cut methods.
Randomized Phase 2 Trial of Intracoronary Nitrite During Acute Myocardial Infarction

Rationale: Preclinical evidence demonstrates that inorganic nitrite, after its in situ conversion to nitric oxide, attenuates consequent myocardial reperfusion injury. Objective: We investigated whether intracoronary injection of nitrite during primary percutaneous coronary intervention might improve infarct size in ST-elevated myocardial infarction. Methods and Results: Patients undergoing primary percutaneous coronary intervention (n=80) were randomized to receive intracoronary (10 mL) sodium nitrite (1.8 &mgr;mol) or NaCl (placebo) before balloon inflation. The primary end point was infarct size assessed by measuring creatine kinase release. Secondary outcomes included infarct size assessed by troponin T release and by cardiac MRI on day 2. Baseline characteristics were similar between the groups. No evidence of differences in creatine kinase release (P=0.92), troponin T (P=0.85), or cardiac MRI–assessed infarct size (P=0.254) were evident. In contrast, there was an improvement in myocardial salvage index (P=0.05) and reduction in major adverse cardiac event at 1 year (2.6% versus 15.8%; P=0.04) in the nitrite group. In a 66-patient subgroup with thrombolysis in myocardial infarction ⩽1 flow, there was reduced serum creatine kinase (P=0.030) and a 19% reduction in cardiac MRI–determined infarct size (P=0.034) with nitrite. No adverse effects of nitrite were detected. Conclusions: In this phase II study, intracoronary nitrite infusion did not alter infarct size, although a trend to improved myocardial salvage index and a significant reduction in major adverse cardiac event was evident. In a subgroup of patients with thrombolysis in myocardial infarction flow ⩽1, nitrite reduced infarct size and major adverse cardiac event and improved myocardial salvage index, indicating that a phase III clinical trial assessing intracoronary nitrite administration as an adjunct to percutaneous coronary intervention in ST-elevated myocardial infarction patients is warranted. Clinical Trial Registration: URL: http://www.clinicaltrials. gov. Unique identifier: NCT01584453.
Adaptation Paths to Novel Motor Tasks Are Shaped by Prior Structure Learning

After extensive practice with motor tasks sharing structural similarities (e.g., different dancing movements, or different sword techniques), new tasks of the same type can be learned faster. According to the recent “structure learning” hypothesis (Braun et al., 2009a), such rapid generalization of related motor skills relies on learning the dynamic and kinematic relationships shared by this set of skills. As a consequence, motor adaptation becomes constrained, effectively leading to a dimensionality reduction of the learning problem; at the same time, adaptation to tasks lying outside the structure becomes biased toward the structure. We tested these predictions by investigating how previously learned structures influence subsequent motor adaptation. Human subjects were making reaching movements in 3D virtual reality, experiencing perturbations either in the vertical or in the horizontal plane. Perturbations were either visuomotor rotations of varying angle or velocity-dependent forces of varying strength. We found that, after extensive training with both kinematic or dynamic perturbations, adaptation to unpracticed, diagonal, perturbations happened along the previously learned structure (vertical or horizontal), and resulting adaptation trajectories were curved. This effect is robust, can be observed on the single-subject level, and occurs during adaptation both within and across trials. Additionally, we demonstrate that structure learning changes involuntary visuomotor reflexes and therefore is not exclusively a high-level cognitive phenomenon.
Cytotoxicity of 35 dental resin composite monomers/additives in permanent 3T3 and three human primary fibroblast cultures.

It was the purpose of this investigation to determine the cytotoxic effects (ED50 concentrations) of 35 monomers or additives identified in commercial dental resin composites. Monolayers of permanent 3T3 cells and three primary human fibroblast types derived from oral tissues (gingiva, pulp, and periodontal ligament) were used as test systems. All substances were tested in concentrations ranging from 0.01 to 5.0 mM. In general, ED50 values varied from 0.06 to > 5 mM. Within the groups of co(monomers), initiators, and cointiators, severe (e.g., Bis-GMA, UDMA, DMBZ, and DMDTA) or moderate (HEMA, BEMA, CQ, DMPT, and DMAPE) cytotoxic effects could be evaluated. Within the group of reaction/decomposition products, only moderate or slight effects were found (ED50: 0.7 to > 5 mM). The inhibitor BHT, the contaminant TPSb, and the photostabilizer HMBP, however, were highly cytotoxic in all cell cultures. In addition, the ED50 values of DBPO and HMBP significantly varied (0.43-3.8 mM, respectively, and 0.44-3.07 mM) with the applied cell culture. Our comprehensive screening shows that for several of the highly cytotoxic composite components, less cytotoxic alternatives are available. Furthermore, there was no cell type identified which was consistently less or more sensitive to the toxic effects of the tested compounds than the others. Primary human periodontal ligament and pulp fibroblasts, however, were found to be more sensitive than 3T3 and gingival fibroblasts to alterations from most tested substances.
Potential use of alexidine dihydrochloride as an apoptosis-promoting anticancer agent

Despite advances in surgery, radiation, and chemotherapy, novel therapeutics are needed for head and neck cancer treatment. The objective of this current study was to evaluate alexidine dihydrochloride as a novel compound lead for head and neck cancers. Using a tetrazolium-based assay, the dose required to reduce cell viability by 50% (ED50) was found to be ∼1.8 μmol/L in FaDu (human hypopharyngeal squamous cancer) and ∼2.6 μmol/L in C666-1 (human undifferentiated nasopharyngeal cancer) cells. In contrast, the ED50 values were much higher in untransformed cells, specifically at ∼8.8 μmol/L in GM05757 (primary normal human fibroblast), ∼8.9 μmol/L in HNEpC (primary normal human nasal epithelial), and ∼19.6 μmol/L in NIH/3T3 (mouse embryonic fibroblast) cells. Alexidine dihydrochloride did not interfere with the activities of cisplatin, 5-fluorouracil, or radiation, and interacted in a less-than-additive manner. DNA content analyses and Hoechst 33342 staining revealed that this compound induced apoptosis. Alexidine dihydrochloride–induced mitochondrial damage was visualized using transmission electron microscopy. Mitochondrial membrane potential (ΔΨM) depolarization was detectable after only 3 hours of treatment, and was followed by cytosolic Ca2+ increase along with loss of membrane integrity/cell death. Caspase-2 and caspase-9 activities were detectable at 12 hours, caspase-8 at 24 hours, and caspase-3 at 48 hours. FaDu cell clonogenic survival was reduced to <5% with 1 μmol/L alexidine dihydrochloride, and, correspondingly, this compound decreased the in vivo tumor-forming potential of FaDu cells. Thus, we have identified alexidine dihydrochloride as the first bisbiguanide compound with anticancer specificity. [Mol Cancer Ther 2006;5(9):2234–40]
Investigating the principal adaptive comfort relationships for young children

Thermal comfort surveys in school classrooms suggest that children have different thermal preferences to adults. This implies a need to revisit the current adult-based thermal comfort models. This paper investigates the principal adaptive comfort relationships that form the basis of adaptive comfort theory, using 2693 pupil thermal sensation responses and measured classroom temperatures from surveys in two naturally ventilated school buildings. The data were examined in two steps. Firstly, each survey set, obtained over one-day visits to the schools, was examined in order to derive the relationship between indoor temperature change and comfort vote with minimum impact of adaptation. Secondly, the data set was investigated over the entire survey period in relation to the weather experienced by the pupils in order to estimate their time for adaptation to outdoor temperature changes. The analysis shows that the basic adaptive comfort relationships are valid for children. However, a difference was found for the correlation coefficients of the comfort temperature to the outdoor running mean temperature between the schools, and a mismatch between their adaptive comfort equations. It is proposed that the difference in the consistency of the weather during the tests is the main reason for this discrepancy.
Salience Network Activity in Perceptual Decisions

The dorsal anterior cingulate cortex (dACC) and the anterior insulae (AIs) are coactivated in various perceptual decision-making (PDM) tasks and form the salience network (SN): a key network in sensory perception and the coordination of behavioral responses. However, what the functional role of SN is, how these key SN nodes interact with each other to form a network in a perceptual decision, and how the network depends on the perceptual difficulty remain largely unknown. In the present study, we measured blood oxygen level-dependent (BOLD) signals using functional magnetic resonance imaging (fMRI). During four PDM tasks (1) face-house discrimination, (2) happy-angry face discrimination, (3) audiovisual asynchrony and synchrony perception, and a (4) random dot motion direction task, we varied the task difficulty and examined the interactions between these SN nodes. In all the experiments, behavioral accuracy decreased and response time increased with task difficulty. The BOLD signal increased in SN nodes with the ambiguity in the sensory information. We also found that there were significant directed functional connections between AIs and dACC in all four tasks and that the interactions between these nodes increased with task difficulty. The observed difficulty-dependent functional architecture of SN suggests that the dACC and AIs are part of a large-scale cognitive system that facilitates sensory integration in PDM.
On the performance of pulsed DS- and hybrid DS/TH-UWB multiple access systems in frequency selective Nakagami fading

Multiple access analysis is presented for pulsed direct sequence (DS) and hybrid DS time hopping (DS/TH) ultra-wideband (UWB) communications considering a Saleh-Valenzuela type clustered frequency selective Nakagami fading channel. A general analytical framework is developed for modeling the multiple access interference (MAI) in low-duty systems that is substantially complicated than analysis of more commonly known DS-code division multiple access (CDMA). Using Rake receiver with maximal ratio combining (MRC), we are able to produce a simple error rate expression for general number of combined paths. The theoretical results are then used for performance evaluation and comparison of the two systems. Results show that in multiple access environment, a DS/TH system may gain many fold performance improvement as compared to a DS system.