Miracle-dz/UniFAR-FTUs huggingface dataset:
Attitude and Propensity to Divorce in Iran: Structural and Ideational Determinants

ABSTRACT Divorce has been increasing worldwide, even in societies where religious impediments to it are strongest. In the Islamic Republic of Iran, divorce rates have risen rapidly since the mid-1990s. In this article, we investigate the attitude and propensity of young Iranians toward divorce and relate these attitudes and propensities to structural and ideational factors. The data are drawn from a survey of 720 married people ages 15 to 29 conducted in the city of Tehran in 2014. The results show that almost half of respondents approved of divorce as a solution for marital problems and one fifth of them have high propensity to divorce. Multivariate analyses indicate that approval of and high propensity toward divorce are significantly associated with ideational factors—namely individualism, secularism, and gender egalitarian views—and structural factors—including education, wife’s employment, and household economic insecurity—even after controlling for demographic variables. We discuss the implications of these findings for the understanding of marital stability in this rapidly changing context.
aV integrins and TGF-β-induced EMT: a circle of regulation

• EMT and pathogenesis: the good, the bad and the ugly• TGF‐b—a central player in EMT• Changes in cell–cell/cell–ECM adhesion in EMT—the role of integrins during EMT• TGF‐b as a regulator of integrin expression during EMT• aV integrins activate TGF‐b ‐ Conformational change activation mechanism ‐ Conformational change activation mechanism with proteolysis• TGF‐b and integrin signalling cross‐talk during EMT• Disease perspectives• Completing the circle• Acknowledgements• Conflicts of interest
Systemic Rather Than Local Heme Oxygenase-1 Overexpression Improves Cardiac Allograft Outcomes in a New Transgenic Mouse1

Heme oxygenase-1 (HO-1), a rate-limiting enzyme in heme catabolism, exhibits potent antioxidant and anti-inflammatory properties. We developed HO-1 transgenic (Tg) mice using a rat HO-1 genomic transgene under the control of the endogenous promoter. Transgene expression was demonstrated by RT-PCR in all studied tissues, and a modest HO-1 overexpression was documented by Western, ELISA, and enzyme activity assays. To assess the effect of local vs systemic HO-1 in the acute rejection response, we used Tg mice as organ donors or recipients of MHC-incompatible heart grafts. In the local HO-1 overexpression model, Tg allografts survived 10.5 ± 0.7 days (n = 10), compared with 6.5 ± 0.4 days (n = 6) for wild-type donor controls (p = 0.0001). In the systemic HO-1 overexpression model, Tg recipients maintained allografts for 26.8 ± 3.4 days (n = 10), compared with 6.3 ± 0.1 days (n = 12) in wild-type controls (p = 0.00009). Inhibition of HO activity by treatment with tin protoporphyrin blunted survival advantage in Tg mice and resulted in acute graft rejection (n = 3). Increased carboxyhemoglobin levels were consistently noted in Tg mice. Comparisons of grafts at day 4 indicated that HO-1 overexpression was inversely associated with vasculitis/inflammatory cell infiltrate in both models. Hearts transplanted into Tg recipients showed decreased CD4+ lymphocyte infiltration and diminished immune activation, as judged by CD25 expression. Thus, although local and systemic HO-1 overexpression improved allograft outcomes, systemic HO-1 led to a more robust protection and resulted in a significant blunting of host immune activation. This Tg mouse provides a valuable tool to study mechanisms by which HO-1 exerts beneficial effects in organ transplantation.
On the Identification of Causal Effects

This paper concerns the assessment of the effects of actions or policies from a combination of: (i) nonexperimental data, and (ii) causal assumptions. The assumptions are encoded in the form of a directed acyclic graph, also called “causal graph”, in which some variables are presumed to be unobserved. The paper establishes new criteria for deciding whether the assumptions encoded in the graph are sufficient for assessing the strength of causal effects and, if the answer is positive, computational procedures are provided for expressing causal effects in terms of the underlying joint distribution.
Adaptive Bayesian estimation using a Gaussian random field with inverse Gamma bandwidth

We consider nonparametric Bayesian estimation inference using a rescaled smooth Gaussian field as a prior for a multidimensional function. The rescaling is achieved using a Gamma variable and the procedure can be viewed as choosing an inverse Gamma bandwidth. The procedure is studied from a frequentist perspective in three statistical settings involving replicated observations (density estimation, regression and classification). We prove that the resulting posterior distribution shrinks to the distribution that generates the data at a speed which is minimax-optimal up to a logarithmic factor, whatever the regularity level of the data-generating distribution. Thus the hierachical Bayesian procedure, with a fixed prior, is shown to be fully adaptive.
The conceptualisation, measurement, and development of mental toughness in military training

43 Introduction 44 Study 1a: Developing the Measure 46 Method 46 Stage I-Item development Stage II-Structural validity Study 1b: Test–Retest Reliability, Concurrent and Predictive Validity 56 Method 56 Participants Instruments Procedure Results 60 Test-retest reliability Concurrent validity
Medicaid and SCHIP Coverage: Findings from California and North Carolina

This article examines experiences under Medicaid and the State Children's Health Insurance Program (SCHIP), drawing on surveys of over 3,000 enrollees in California and North Carolina in 2002. In both States, Medicaid enrollees were less likely than SCHIP enrollees to have parents who were covered by employer-sponsored insurance (ESI). With the exception of dental care and provider perceptions, access experiences were fairly comparable across the two programs, despite differences in the characteristics of the children served by the two programs. Relative to being uninsured, Medicaid enrollment was found to improve access to care along a number of different dimensions, controlling for other factors. Furthermore, this study emphasizes the need for continued evaluation of access to care for both programs.
p53 Autoantibodies as Potential Detection and Prognostic Biomarkers in Serous Ovarian Cancer

Background: This study examined the value of serum p53 autoantibodies (p53-AAb) as detection and prognostic biomarkers in ovarian cancer. Methods: p53-AAb were detected by ELISA in sera obtained preoperatively from women undergoing surgery for a pelvic mass. This group included women subsequently diagnosed with invasive serous ovarian cancer (n = 60), nonserous ovarian cancers (n = 30), and women with benign disease (n = 30). Age-matched controls were selected from the general population (n = 120). Receiver operating characteristic curves were constructed to compare the values of p53-AAb, CA 125, and HE4 as a screening biomarker. Kaplan-Meier curves and Cox proportional hazards modeling were used to assess its prognostic value on survival. Results: p53-AAb were detected in 25 of 60 (41.7%) of serous cases, 4 of 30 (13.3%) nonserous cases, 3 of 30 (10%) benign disease cases, and 10 of 120 (8.3%) controls (combined P = 0.0002). p53-AAb did not significantly improve the detection of cases [area under the curve (AUC), 0.69] or the discrimination of benign versus malignant disease (AUC, 0.64) compared with CA 125 (AUC, 0.99) or HE4 (AUC, 0.98). In multivariate analysis among cases, p53-AAb correlated only with a family history of breast cancer (P = 0.01). Detectable p53 antibodies in pretreatment sera were correlated with improved overall survival (P = 0.04; hazard ratio, 0.57; 95% confidence interval, 0.33-0.97) in serous ovarian cancer. Conclusions: Antibodies to p53 are detected in the sera of 42% of patients with advanced serous ovarian cancer. Impact: Although their utility as a preoperative diagnostic biomarker, beyond CA 125 and HE4, is limited, p53-AAb are prognostic for improved overall survival. Cancer Epidemiol Biomarkers Prev; 19(3); 859–68
Using mobile phones for vocabulary activities: Examining the effect of the platform

While problems such as small screens and inconvenient keypads have been pointed out by researchers (e.g., Thornton & Houser, 2002), we still have little knowledge of how the mobile platform affects the way in which activities are completed and how learners make decisions about using mobile phones. Stockwell (2007b) provided preliminary evidence that learners generally require more time to complete vocabulary activities and achieved slightly lower scores on mobile phones when compared to completing the same activities on desktop computers, but data in the study were limited. The current study examines 175 pre-intermediate learners of English who could choose to complete vocabulary activities on either a mobile phone or a desktop computer to identify the effect of the mobile platform. Data were collected from three cohorts of learners over a three-year period, and learner activity was analysed for the amount of time required to complete activities on both platforms and the scores they achieved for the activities. The results of the study are discussed in terms of how the platform affects learners’ ability to complete tasks, whether continued usage contributes to improved performance or sustained usage of the mobile platform over time. Trends across the yearly cohorts were also identified.
Bird orientation: compensation for wind drift in migrating raptors is age dependent

Despite the potentially strong effect of wind on bird orientation, our understanding of how wind drift affects migrating birds is still very limited. Using data from satellite-based radio telemetry, we analysed the effect of changing winds on the variation of the track direction of individual birds. We studied adults and juveniles of two raptor species, osprey Pandion haliaetus and honey buzzard Pernis apivorus, on autumn migration between North Europe and Africa, and demonstrate an important difference between the age categories of both species in the extent of wind drift. For juveniles, side- and following-wind components affected the rates of movement perpendicular to and along the mean direction, respectively, to a similar degree, suggesting full wind drift. By contrast, for adults the rate of crosswind displacement was significantly smaller than the effect of wind on forward movement, showing much reduced wind drift (29%). This indicates that adults have acquired a more sophisticated orientation system, permitting detection of and compensation for wind drift, than juveniles. These drift effects are likely to reduce the ability of juveniles to locate species-specific wintering areas in case of rapid climatic wind change.
Prevalence and symptomatology of depression in older people living in institutions in England and Wales.

BACKGROUND Epidemiological studies have shown that depression is common in institutional settings. However, the symptomatology of depression in this group has not been compared to those living in the community. AIMS To estimate the prevalence of depression and depressive symptomatology in participants living in institutions and compare these to people living in other settings. METHOD The Medical Research Council Cognitive Function and Ageing Study (MRC CFAS) is a population-based cohort comprising 13,004 individuals aged 65 and above, from five sites across England and Wales. Following screening, a stratified random sub-sample of 2,640 participants received the Geriatric Mental State (GMS) examination of whom 340 resided in institutions. Diagnoses of depression were made using the Automated Geriatric Examination for Computer-assisted Taxonomy system (AGECAT). RESULTS The prevalence of depression in those living in institutions was 27.1% (95% CI 17.8-36.3) compared to 9.3% (95% CI 7.8-10.9) in those living at home. Symptoms relating to depressed mood, severity of illness (e.g. wishing to be dead, future looking bleak) and some non-specific symptoms were more common in those living in residential homes. Depression was significantly associated with younger age (P = 0.002) and high functional disability (P = 0.009) in those living in institutions. CONCLUSIONS Consistent with previous estimates, depression was highly prevalent in institutions, particularly in younger individuals with severe functional impairment. Those in institutions report considerably more symptoms of depression. Finding interventions which address these symptoms might improve quality of life for people in institutions, irrespective of formal diagnoses.
Asymmetry of Dopamine D2/3 Receptor Availability in Dorsal Putamen and Body Mass Index in Non-obese Healthy Males

The dopaminergic system is involved in the regulation of food intake, which is crucial for the maintenance of body weight. We examined the relationship between striatal dopamine (DA) D2/3 receptor availability and body mass index (BMI) in 25 non-obese healthy male subjects using [11C]raclopride and positron emission tomography. None of [11C]raclopride binding potential (BP) values (measures of DA D2/3 receptor availability) in striatal subregions (dorsal caudate, dorsal putamen, and ventral striatum) in the left and right hemispheres was significantly correlated with BMI. However, there was a positive correlation between the right-left asymmetry index of [11C]raclopride BP in the dorsal putamen and BMI (r=0.43, p<0.05), suggesting that greater BMI is linked with higher receptor availability in the right dorsal putamen relative to the left in non-obese individuals. The present results, combined with previous findings, may also suggest neurochemical mechanisms underlying the regulation of food intake in non-obese individuals.
Interictal mood and personality disorders in temporal lobe epilepsy and juvenile myoclonic epilepsy.

BACKGROUND: Mood disorders have been described as the commonest psychiatric disorders in patients with temporal lobe epilepsy. Secondary depression in temporal lobe epilepsy could be interpreted either as an adjustment reaction to a chronic disease or as a limbic dysfunction. To clarify this issue, a controlled study of psychiatric disorders was conducted in different forms of epileptic and non-epileptic chronic conditions. METHODS: Twenty outpatients with temporal lobe epilepsy, 18 outpatients with juvenile myoclonic epilepsy--a primary generalised seizure disorder--20 matched type I diabetic patients, and 20 matched normal controls were assessed by a structured interview (SADS) and by self rating scales (Beck depression inventory (BDI) and the state and trait anxiety scales STAIX1 and STAIX2). RESULTS: Sixteen (80%) patients with temporal lobe epilepsy fulfilled the criteria for a psychiatric diagnosis at the SADS interview with a significantly higher frequency than patients with juvenile myoclonic epilepsy (22%) and diabetic patients (10%) (P < 0.0001). The most frequent disorder in temporal lobe epilepsy was a mood disorder: 11 (55%) patients with temporal lobe epilepsy had depression compared with three patients with juvenile myoclonic epilepsy and two diabetic patients (P < 0.001). Eight patients with temporal lobe epilepsy with an affective disorder also had a comorbid personality or anxiety disorder. Patients with temporal lobe epilepsy scored significantly higher on BDI, STAIX1, and STAIX2 than the three control groups (P < 0.001, P < 0.01, P < 0.001). CONCLUSIONS: Patients with temporal lobe epilepsy have a higher incidence of affective and personality disorders, often in comorbidity, than patients with juvenile myoclonic epilepsy and diabetic patients suggesting that these psychiatric disorders are not an adjustment reaction to a chronic disease but rather reflect a limbic dysfunction.
Delayed Intrinsic Activation of an NMDA-Independent CaM-kinase II in a Critical Time Window Is Necessary for Late Consolidation of an Associative Memory

Calcium/calmodulin-dependent kinases (CaM-kinases) are central to various forms of long-term memory (LTM) in a number of evolutionarily diverse organisms. However, it is still largely unknown what contributions specific CaM-kinases make to different phases of the same specific type of memory, such as acquisition, or early, intermediate, and late consolidation of associative LTM after classical conditioning. Here, we investigated the involvement of CaM-kinase II (CaMKII) in different phases of associative LTM induced by single-trial reward classical conditioning in Lymnaea, a well established invertebrate experimental system for studying molecular mechanisms of learning and memory. First, by using a general CaM-kinase inhibitor, KN-62, we found that CaM-kinase activation was necessary for acquisition and late consolidation, but not early or intermediate consolidation or retrieval of LTM. Then, we used Western blot-based phosphorylation assays and treatment with CaMKIINtide to identify CaMKII as the main CaM-kinase, the intrinsic activation of which, in a critical time window (∼24 h after learning), is central to late consolidation of LTM. Additionally, using MK-801 and CaMKIINtide we found that acquisition was dependent on both NMDA receptor and CaMKII activation. However, unlike acquisition, CaMKII-dependent late memory consolidation does not require the activation of NMDA receptors. Our new findings support the notion that even apparently stable memory traces may undergo further molecular changes and identify NMDA-independent intrinsic activation of CaMKII as a mechanism underlying this “lingering consolidation. ” This process may facilitate the preservation of LTM in the face of protein turnover or active molecular processes that underlie forgetting.
Adjuvant high dose rate brachytherapy for soft tissue sarcomas: initial experience report

Purpose Adjuvant high-dose-rate brachytherapy (HDRBT) offers advantages over low dose rate brachytherapy (LDRBT), although there are little data on local tumor control and treatment related toxicity. We report outcome in patients with primary, recurrent, and metastatic extremity and superficial trunk soft tissue sarcoma. Material and methods Eleven patients (12 sites) with intermediate or high grade sarcoma were treated with adjuvant HDRBT following surgical resection. Patients were treated at 3.4 Gy fractions delivered twice daily to a total dose of 34 Gy (1 patient received 9 fractions). Results With median follow-up of 20.8 months, 1 patient developed a local recurrence. 2-year local control and overall survival are 89% and 71%, respectively. Wound complications occurred in 3 sites. Two of the wound complications developed in the area of previous external beam radiotherapy (EBRT). Conclusion Surgical resection followed by HDRBT is associated with excellent early local tumor control and acceptable wound complication.
A method for detection of structure

Context. In order to understand the evolution of molecular clouds it is important to identify the departures from self-similarity associated with the scales of self-gravity and the driving of turbulence. Aims. A method is described based on structure functions for determining whether a region of gas, such as a molecular cloud, is fractal or contains structure with characteristic scale sizes. Methods. Using artificial data containing structure it is shown that derivatives of higher order structure functions provide a powerful way to detect the presence of characteristic scales should any be present and to estimate the size of such structures. The method is applied to observations of hot H2 in the Kleinman-Low nebula, north of the Trapezium stars in the Orion Molecular Cloud, including both brightness and velocity data. The method is compared with other techniques such as Fourier transform and histogram techniques. Results. It is found that the density structure, represented by H2 emission brightness in the K-band (2-2.5micron), exhibits mean characteristic sizes of 110, 550, 1700 and 2700AU. The velocity data show the presence of structure at 140, 1500 and 3500AU. Compared with other techniques such as Fourier transform or histogram, the method appears both more sensitive to characteristic scales and easier to interpret.
Administration of B-group vitamins reduces circulating homocysteine in polycystic ovarian syndrome patients treated with metformin: a randomized trial.

BACKGROUND The aim of the current study was to assess the effects of B-group vitamins and folic acid administration on serum levels of homocysteine (Hcy) in patients with polycystic ovarian syndrome (PCOS) on short-term metformin treatment. METHODS Patients were randomly assigned to one of three treatment groups. Group 1 patients (n = 20) received metformin (850 mg twice daily); group 2 patients (n = 20) received metformin (850 mg twice daily) and B-group vitamins (vitamin B1, 250 mg; vitamin B6, 250 mg; vitamin B12, 1000 microg twice daily); and group 3 patients (n = 20) received metformin (850 mg twice daily) and folic acid (174 microg twice daily). In all groups, lipid profiles and plasma total Hcy, vitamin B12, folic acid and glucose levels were recorded at baseline and at 3 months. RESULTS A 26.5% increase in Hcy levels was seen after 12 weeks of metformin therapy, while 21.17 and 8.33% decreases in Hcy levels were detected when B-group vitamins or folic acid plus metformin were given respectively. There were no statistically significant differences recorded in insulin sensitivity using homeostasis model assessment in the three groups. CONCLUSION These findings suggest that B-group vitamins and folic acid administration counteract the Hcy-increasing effect seen with metformin therapy.
Exposure to media and theory-of-mind development in preschoolers

Exposure to different forms of narrative media may influence children’s development of theory-of-mind. Because engagement with fictional narratives provides one with information about the social world, and possibly draws upon theory-of-mind processes during comprehension, exposure to storybooks, movies, and television may influence theory-of-mind development. We examined 4–6 year-olds’ inferred exposure to children’s literature, television, and film, using an objective measure that controls for socially desirable responding. Theory-of-mind was assessed using a battery of five tasks. Controlling for age, gender, vocabulary, and parental income, inferred exposure to children’s storybooks predicted theory-ofmind abilities. Inferred exposure to children’s movies also predicted theory-of-mind development, but inferred exposure to children’s television did not. © 2009 Elsevier Inc. All rights reserved.
The influence of live yeast cells (Saccharomyces cerevisiae) on the performance of grazing dairy sheep in late lactation

A feeding trial was conducted in order to evaluate the influence of live yeast cells ( saccharomyces cerevisiae ) on milk production and composition, and on blood parameters in late lactation. The experiment was performed on forty Croatian crossbred dairy sheep divided into a control group without live yeast cells (CD = control diet) and the experimental group with live yeast cells in the diet (YC = diet with saccharomyces cerevisiae) . The diet was based on pasture and concentrate containing corn (66.3%), soybean meal (18.7%), bran (6%) and alfalfa meal (4%). Supplementation with live yeast cells significantly increased the total milk yield in the 23 rd week (P 0.5). The chemical composition of the milk was not influenced by the treatments with the exception of milk fat that was significantly higher in YC group. Blood parameters were not affected by the treatment. We conclude that supplementation with live yeast cells, under the conditions of our experiment, had no statistically significant beneficial effects on the performance of dairy ewes during late lactation. High concentrate diet, the stage of lactation and high temperatures may have decreased the response to live yeast cells.