Miracle-dz/UniFAR-FTUs huggingface dataset:
Navigating the space: evaluating a 3D-input device in placement and docking tasks

We present a study investigating the performance in a 3D object manipulation task with a mouse and a dedicated input device (SpaceNavigator). Previous research delivered ambiguous results about the performance in different 3D tasks. Therefore we used placement (only translation) as well as docking (translation and rotation) tasks. Twelve participants experienced with 3D software took part in the study. They had to translate and rotate 30 cubes with the mouse and the SpaceNavigator (altogether 60 tasks) to place them on a chessboard in Autodesk Maya. The results show an outperformance of the mouse over the SpaceNavigator in the placement tasks but not in the docking tasks, which require a higher extent of object manipulation. Although the SpaceNavigator did not outperform the mouse, considering the number of tasks with the SpaceNavigator and further results of the study (like the learning effect and subjective feedback), the usage of a higher degree-of-freedom device for tasks with multiple simultaneous object manipulations seems reasonable.
The Influence of Perception on the Distribution of Multiple Symmetries in Nature and Art

Much is already known about single mirror symmetry, but multiple mirror symmetry is still understood poorly. In particular, perceptually, multiple symmetry does not seem to behave as suggested by the number of symmetry axes alone. Here, theoretical ideas on single symmetry perception and their extensions to multiple symmetry are discussed alongside empirical findings on multiple symmetry perception. The evidence suggests that, apart from the number of axes, also their relative orientation is perceptually relevant. This, in turn, suggests that perception is responsible for the preponderance of 3-fold and 5-fold symmetries in flowers as well as for their absence in decorative art.
Sea level at Saint Paul Island, southern Indian Ocean, from 1874 to the present

A data archeology exercise was carried out on sea level observations recorded during the transit of Venus across the Sun observed in 1874 from Saint Paul Island (38°41′S, 77°31 E) in the southern Indian Ocean. Historical (1874) and recent (1994-2009) sea level observations were assembled into a consistent time series. A thorough check of the data and its precise geodetic connection to the same datum was only possible thanks to the recent installation of new technologies (GPS buoy and radar water level sensor) and leveling campaigns. The estimated rate of relative sea level change, spanning the last 135 years at Saint Paul Island, was not significantly different from zero (−0.1 ± 0.3 mm yr−1), a value which could be reconciled with estimates of global average sea level rise for the 20th century assuming the DORIS vertical velocity estimate at Amsterdam Island (100 km distant) could be applied to correct for the land motion at the tide gauge. Considering the scarcity of long-term sea level data in the Southern Hemisphere, the exercise provides an invaluable additional observational constraint for further investigations of the spatial variability of sea level change, once vertical land rates can be determined.
Unstable Subaxial Cervical Spine Injury With Normal Computed Tomography and Magnetic Resonance Initial Imaging Studies: A Report of Four Cases and Review of the Literature

Study Design. Case series. Objective. To describe 4 cases of unstable subaxial cervical spine injury not demonstrated with initial radiograph, computed tomography (CT), and magnetic resonance (MR) imaging. Summary of Background Data. When evaluating the cervical spine for ligamentous or osseous injuries in the blunt trauma patient population, negative predictive value measurements of 100% for CT and MR imaging have been published. Unstable subaxial cervical spine injury has rarely been reported in the spine literature in conjunction with initial radiograph, CT, and MR imaging demonstrating no osseous or ligamentous injury. Historically, reports of subacute cervical spine instability following trauma exist and were presented before the availability of MR and multidetector CT imaging. Methods and Results. We report 4 examples of unstable subaxial cervical spine injury each with initial imaging interpreted as negative. All 4 cases presented at a level-one tertiary care facility. Follow-up radiographs demonstrated unstable cervical spine injuries requiring surgical stabilization. Conclusion. Notwithstanding high sensitivities, specificities, and negative predictive values for cervical spine imaging and “clearance” mechanisms, 4 cases that illustrate the potential for undetected unstable cervical spine injuries are presented. Tremendous advancements in medical imaging have been made. However, radiograph, CT, and MR imaging may still fail to accurately translate the anatomic and dynamic complexity of the cervical spine into digital images that accurately guide clinical practice. A full understanding of and keen appreciation for the fact that no imaging technique, classification method, or clearance protocol can produce 100% sensitivity at all times is essential. These case reports cumulatively demonstrate a 0.04% to 0.2% incidence of undetected cervical injury requiring surgical stabilization. Removing cervical collar immobilization as quickly as possible based on negative interpretation of imaging data may prove harmful in a measurable percentage of patients and must be undertaken with caution only after clinical correlation and strict follow-up is established.
An Empirical-Assessment Of The Impact Of Alternative Task Presentation Modes On Decision-Making Research In Auditing

The experimental designs used in most audit decision-making research have restricted task presentation mode (i.e., the method of presenting case information to subjects) to written instruments. In practice, though, auditors typically make decisions from information presented in any one of three modes of presentation: visual (e.g., review of audit workpaper documentation), auditory (e.g., face-to-face or telephone conversations between an in-charge auditor and a supervisor), or visual/auditory (e.g., face-to-face or telephone conversations about a proposed, workpaperdocumented audit adjustment). In using written instruments exclusively, audit decision-making research has actualized the visual presentation mode but systematically overlooked the auditory and visual/auditory modes, thereby assuming implicitly that task presentation mode does not impact a subject's decisions. However, the experimental psychology literature has reported evidence suggesting that task presentation mode can affect decisions (e.g., Jensen [1971]). In addition, and equally important, ignoring alternative presentation modes threatens the external validity of reported
Transcriptional Factor Mutations Reveal Regulatory Complexities of Heat Shock and Newly Identified Stress Genes in Saccharomyces cerevisiae *

A computer-aided pattern search of the entire yeast genome was designed and used to identify 186 putative stress response element-regulated genes in Saccharomyces cerevisiae. Transcript levels of eight of these candidate genes were examined, and three (37%) were shown to be heat shock- and DNA damage-inducible and to require the Msn2p and Msn4p transcriptional activators for stress regulation. Significantly, several heat shock protein (HSP) genes were identified in this computer search. Using a series of single and multiple regulatory mutants, we demonstrate unexpected regulatory complexities among the HSP genes from S. cerevisiae following heat shock.
Identification of Residues Critical for Regulation of Protein Stability and the Transactivation Function of the Hypoxia-inducible Factor-1α by the von Hippel-Lindau Tumor Suppressor Gene Product*

Under normoxic conditions the hypoxia-inducible factor-1α (HIF-1α) protein is targeted for degradation by the von Hippel-Lindau (pVHL) tumor suppressor protein acting as an E3 ubiquitin ligase. Binding of pVHL to HIF-1α is dependent on hydroxylation of specific proline residues by O2-dependent prolyl 4-hydroxylases. Upon exposure to hypoxia the hydroxylase activity is inhibited, resulting in stabilization of HIF-1α protein levels and activation of transcription of target genes. One of the two critical proline residues, Pro563 in mouse HIF-1α, is located within a bifunctional domain, the N-terminal transactivation domain (N-TAD), which mediates both pVHL-dependent degradation at normoxia and transcriptional activation at hypoxia. Here we have identified two N-TAD residues, Tyr564 and Ile565, which, in addition to Pro563, were critical for pVHL-mediated degradation at normoxia. We have also identified D568A/D569A/D570A, F571A, and L573A as mutations of the N-TAD that abrogated binding to pVHL both in vitro andin vivo, and constitutively stabilized N-TAD against degradation. Moreover, the mutations Y564G, L556A/L558A, and F571A/L573A drastically reduced the transactivation function of either the isolated N-TAD or full-length HIF-1α in hypoxic cells. Interestingly, the P563A mutant exhibited a constitutively active and potent transactivation function that was enhanced by functional interaction with the transcriptional coactivator protein CREB-binding protein. In conclusion, we have identified by mutation analysis several residues that are critical for either one or both of the interdigitated and conditionally regulated degradation and transactivation functions of the N-TAD of HIF-1α.
Proteins Involved in Meiotic Recombination: A Role in Male Infertility?

Meiotic recombination results in the formation of crossovers, by which genetic information is exchanged between homologous chromosomes during prophase I of meiosis. Recombination is a complex process involving many proteins. Alterations in the genes involved in recombination may result in infertility. Molecular studies have improved our understanding of the roles and mechanisms of the proteins and protein complexes involved in recombination, some of which have function in mitotic cells as well as meiotic cells. Human gene sequencing studies have been performed for some of these genes and have provided further information on the phenotypes observed in some infertile individuals. However, further studies are needed to help elucidate the particular role(s) of a given protein and to increase our understanding of these protein systems. This review will focus on our current understanding of proteins involved in meiotic recombination from a genomic perspective, summarizing our current understanding of known mutations and single nucleotide polymorphisms that may affect male fertility by altering meiotic recombination.
Correlates of Selected Indices of Physical Fitness And Duration of Incarceration among Inmates in Some Selected Nigeria Prisons

Background Incarceration has been associated with reduced physical activity. However, physical inactivity is a major cause of morbidity and mortality. The aim of the present study was therefore, to evaluate the incidence and relationship between the measures of physical fitness and the duration of incarceration in of inmates in Kano-Nigeria prisons. Method A cross-sectional study was done to determine the relationship between the measures of physical fitness and the duration of incarceration of inmates in Kano prisons. Subjects' physical fitness level (cardio-respiratory fitness, body mass index and waist circumference) was assessed using standardized protocols. Simple percentage, Pearson moment correlation test and student's t-test were used to analyze variables of interest. Result One hundred and sixteen inmates; 108 (93.1%) males and 8 (6.9%) females participated in the study. The study revealed high (93.1%) prevalence of low cardio-respiratory fitness among inmates and significant correlation between the selected indices of physical fitness (cardio-respiratory fitness, body mass index and waist circumference) and duration of incarceration. Conclusion The prevalence of low cardio-respiratory fitness was high among inmates and long period of inadequate physical activity may be implicated as causative factor of low physical fitness among inmates in Kano prison. Prison administration and staff should encourage healthy inmate behavior. Provision of adequate facilities to encourage physical activity and sports participation is highly needed.
Prevalence, Risk, and Correlates of Posttraumatic Stress Disorder Across Ethnic and Racial Minority Groups in the United States

Objectives:We assess whether posttraumatic stress disorder (PTSD) varies in prevalence, diagnostic criteria endorsement, and type and frequency of potentially traumatic events (PTEs) among a nationally representative US sample of 5071 non-Latino whites, 3264 Latinos, 2178 Asians, 4249 African Americans, and 1476 Afro-Caribbeans. Methods:PTSD and other psychiatric disorders were evaluated using the World Mental Health-Composite International Diagnostic Interview (WMH-CIDI) in a national household sample that oversampled ethnic/racial minorities (n=16,238) but was weighted to produce results representative of the general population. Results:Asians have lower prevalence rates of probable lifetime PTSD, whereas African Americans have higher rates as compared with non-Latino whites, even after adjusting for type and number of exposures to traumatic events, and for sociodemographic, clinical, and social support factors. Afro-Caribbeans and Latinos seem to demonstrate similar risk to non-Latino whites, adjusting for these same covariates. Higher rates of probable PTSD exhibited by African Americans and lower rates for Asians, as compared with non-Latino whites, do not appear related to differential symptom endorsement, differences in risk or protective factors, or differences in types and frequencies of PTEs across groups. Conclusions:There appears to be marked differences in conditional risk of probable PTSD across ethnic/racial groups. Questions remain about what explains risk of probable PTSD. Several factors that might account for these differences are discussed, as well as the clinical implications of our findings. Uncertainty of the PTSD diagnostic assessment for Latinos and Asians requires further evaluation.
Correlation-immunity of nonlinear combining functions for cryptographic applications

Pseudonoise generators for cryptographic applications consisting of several linear feedback shift registers with a nonlinear combining function have been proposed as running key generators in stream ciphers. These running key generators eau sometimes be broken by (ciphertext-only) correlation attacks on individual subsequences. A new class of combining functions is presented, which provides better security against such attacks. The security is quantified by the smallest number m + 1 of subsequences that must be simultaneously considered in a correlation attack. A necessary condition for such m th-order correlation-immunity is proved. A recursive construction is given that permits the construction of an m th-order immune combining function for n subsequences for any m and n with 1 \leq m . Finally, the trade-off between the length of the linear equivalent of the nonlinear generator and the order m of its immunity against correlation attacks is considered.
Are Predictive Equations for Estimating Resting Energy Expenditure Accurate in Asian Indian Male Weightlifters?

Background: The accuracy of existing predictive equations to determine the resting energy expenditure (REE) of professional weightlifters remains scarcely studied. Our study aimed at assessing the REE of male Asian Indian weightlifters with indirect calorimetry and to compare the measured REE (mREE) with published equations. A new equation using potential anthropometric variables to predict REE was also evaluated. Materials and Methods: REE was measured on 30 male professional weightlifters aged between 17 and 28 years using indirect calorimetry and compared with the eight formulas predicted by Harris–Benedicts, Mifflin-St. Jeor, FAO/WHO/UNU, ICMR, Cunninghams, Owen, Katch-McArdle, and Nelson. Pearson correlation coefficient, intraclass correlation coefficient, and multiple linear regression analysis were carried out to study the agreement between the different methods, association with anthropometric variables, and to formulate a new prediction equation for this population. Results: Pearson correlation coefficients between mREE and the anthropometric variables showed positive significance with suprailiac skinfold thickness, lean body mass (LBM), waist circumference, hip circumference, bone mineral mass, and body mass. All eight predictive equations underestimated the REE of the weightlifters when compared with the mREE. The highest mean difference was 636 kcal/day (Owen, 1986) and the lowest difference was 375 kcal/day (Cunninghams, 1980). Multiple linear regression done stepwise showed that LBM was the only significant determinant of REE in this group of sportspersons. A new equation using LBM as the independent variable for calculating REE was computed. REE for weightlifters = −164.065 + 0.039 (LBM) (confidence interval −1122.984, 794.854]. This new equation reduced the mean difference with mREE by 2.36 + 369.15 kcal/day (standard error = 67.40). Conclusion: The significant finding of this study was that all the prediction equations underestimated the REE. The LBM was the sole determinant of REE in this population. In the absence of indirect calorimetry, the REE equation developed by us using LBM is a better predictor for calculating REE of professional male weightlifters of this region.
Proton magnetic resonance spectroscopy of polymorphonuclear leukocytes from patients with serious bacterial infections.

Triacylglycerols in human neutrophils exposed to proinflammatory stimuli generate a high-resolution proton magnetic resonance (1H MR) spectrum. Lipid cross-peak F volumes in neutrophils from patients with inflammatory conditions were measured. Values in patients hospitalized with localized infections (14.4 +/- 9.0; mean +/- SD) or bacteremia (19.3 +/- 9.7) were significantly higher than in patients with noninflammatory conditions (6.2 +/- 5.3) and healthy controls (2.0 +/- 3.0; P < .001). The positive predictive value of F volumes > 10 was 93% for all infection; the negative predictive value of volumes < or = 10 was 68% for all infection and 92% for bacteremia. Plasma lipopolysaccharide (LPS) concentrations were highest in bacteremic patients but did not correlate with levels of tumor necrosis factor-alpha (TNF alpha) or interleukin-6. In vitro, LPS increased F volumes of control neutrophils from 2.0 +/- 3.0 to 37.2 +/- 6.7 (P < .001); TNF alpha had no effect. F volumes in 1H MR spectra may be useful clinically to discriminate between serious bacterial infection and other inflammatory conditions. TNF alpha is not the stimulus for generation of lipid spectra in vivo.
Patient, Surgery, and Hospital Related Risk Factors for Surgical Site Infections following Total Hip Arthroplasty

Surgical site infections (SSI) following total hip arthroplasty (THA) have a significantly adverse impact on patient outcomes and pose a great challenge to the treating surgeon. Therefore, timely recognition of those patients at risk for this complication is very important, as it allows for adopting measures to reduce this risk. This review discusses literature reported risk factors for SSI after THA. These can be classified into patient-related factors (age, gender, obesity, comorbidities, history of infection, primary diagnosis, and socioeconomic profile), surgery-related factors (allogeneic blood transfusion, DVT prophylaxis and coagulopathy, duration of surgery, antibiotic prophylaxis, bearing surface and fixation, bilateral procedures, NNIS index score, and anesthesia type), and hospital-related factors (duration of hospitalization, institution and surgeon volume, and admission from a healthcare facility). All these factors are discussed with respect to potential measures that can be taken to reduce their effect and consequently the overall risk for infection.
Mouse mammary tumor virus-like gene sequences in breast tumors of Australian and Vietnamese women.

PURPOSE There is considerable evidence that the presence of mouse mammary tumor virus (MMTV)-like gene sequences in human breast cancer is highly associated with human breast carcinoma. Previous studies have found MMTV-like gene sequences in 38% of breast cancer tissue from United States women. The prevalence of these sequences in Australian and Vietnamese women has never been reported. EXPERIMENTAL DESIGN Using PCR and primers that amplify MMTV-like gene sequences, we tested cancerous and benign breast tissue from Caucasian-Australian, Vietnamese-Australian, and Vietnamese women. RESULTS MMTV-like gene sequences were amplified in 19 of 45 (42.2%) archival breast cancer biopsy tissues from Caucasian-Australian women, but only 1 of 120 (0.8%) and 0 of 41 breast cancer biopsy tissues from Vietnamese and Vietnamese-Australian women, respectively. The same sequences were found in only 2 of 111 (1.8%) and 0 of 60 normal (benign) breast tissue samples from Australian and Vietnamese women, respectively. CONCLUSIONS MMTV-like gene sequences are found in only some human populations and are rarely found in normal human breast tissue from all populations, suggesting they are not present in the normal human genome and have been acquired.
Pandemic (H1N1) 2009 Virus and Down Syndrome Patients

We compared prevalence of hospitalization, endotracheal intubation, and death among case-patients with and without Down syndrome during pandemic (H1N1) 2009 in Mexico. Likelihoods of hospitalization, intubation, and death were 16-fold, 8-fold, and 335-fold greater, respectively, for patients with Down syndrome. Vaccination and early antiviral drug treatment are recommended during such epidemics.
Decision-making deficits in alcohol-dependent patients with and without comorbid personality disorder.

BACKGROUND Impairments in decision making are a consistent finding in substance use disorder (SUD) populations. However, decision-making deficits are not specific for SUDs and are also reported in the context of other psychiatric disorders such as antisocial and borderline personality disorders (PDs). Given the frequent comorbidity between SUD and cluster B PD, it might be questioned whether the decision-making impairments typically reported in SUD populations reflect the addictive disorder, the cluster B PD, or a combination of the 2. METHODS In the current study, we compare the decision-making performance of non-substance-abusing controls (n=53) on the Iowa Gambling Task (IGT) with the decision-making performance of 3 abstinent alcohol-dependent samples, i.e., alcoholic patients without any PD (n=38), alcoholic patients with a cluster A or C PD (n=19), and alcoholic patients with a cluster B PD (n=23). RESULTS Overall, all 3 alcohol-dependent subsamples performed inferior compared with controls. Between alcoholic subsamples, the alcoholic patients with a cluster A or C PD had the highest IGT score, followed by the alcoholic patients without a PD, while the cluster B alcoholic patients were the most impaired. CONCLUSION These findings suggest that impairments in decision making underlie both alcohol dependence and cluster B PD, and alcoholic patients with a comorbid cluster B PD are particularly impaired in their decision making. These deficits may underlie the severe problems that characterize cluster B alcoholic patients specifically in inappropriate behaviors (e.g., poly substance abuse, legal, and professional dysfunction).