Miracle-dz/UniFAR-FTUs huggingface dataset:
iii FRACTURE STRENGTH OF ALL-CERAMIC RESTORATIONS AFTER FATIGUE

Fracture strength of monolithic and bilayered LAVA and e. max lower molar crowns after load cycling was measured and compared. The study included three groups (n = 8) from LAVA zirconia and three groups from e. max lithium disilicate to compare influences of different layers, thicknesses and manufacturing techniques. Prefabricated anatomically designed crowns were cemented to dies made from Z 100 composite resin using Rely X Luting Plus resin modified glass ionomer cement. Cemented crowns were stored at 37° C for 24 hours then cyclic loaded to test fatigue properties. The crowns were loaded to 200,000 cycles at 25N at a rate of 40 cycles / minute to simulate oral function. Subsequently, fracture properties for each group were measured using an Instron Universal Testing machine. Microscopic evaluation of the surface of fatigued samples did not reveal microcracks at the end of 50,000 cycles but minor wear facets were observed at the site of contact from the steatite ball antagonist. Crowns from LAVA bilayered groups showed step by step fractures while crowns from all other groups fractured as a single event as observed by the high speed camera. Zirconia bilayered crowns showed the highest loads to fracture while lithium disilicate monolithic crowns showed the lowest, within the limitations of the study. The study also showed that monolithic zirconia crowns of 0.6mm thickness resulted in relatively high magnitude for forces at fracture.
Diversification of African tree frogs (genus Leptopelis) in the highlands of Ethiopia

The frog genus Leptopelis is composed of ~50 species that occur across sub‐Saharan Africa. The majority of these frogs are typically arboreal; however, a few species have evolved a fossorial lifestyle. Most species inhabit lowland forests, but a few species have adapted to high elevations. Five species of Leptopelis occupy the Ethiopian highlands and provide a good opportunity to study the evolutionary transition from an arboreal to a fossorial lifestyle, as well as the diversification in this biodiversity hot spot. We sequenced 14 nuclear and three mitochondrial genes, and generated thousands of SNPs from ddRAD sequencing to study the evolutionary relationships of Ethiopian Leptopelis. The five species of highland Leptopelis form a monophyletic group, which diversified during the late Miocene and Pliocene. We found strong population structure in the fossorial species L. gramineus, with levels of genetic differentiation between populations similar to those found between arboreal species. This could indicate that L. gramineus is a complex of cryptic species. We propose that after the original colonization of the Ethiopian highlands by the ancestor of the L. gramineus group, episodes of vicariance fragmented the ancestral populations of this group. We also report the re‐evolution of arboreality in L. susanae, which evolved from a fossorial ancestor, a rare ecological switch in frogs that had previously been reported only once.
How Developers' Collaborations Identified from Different Sources Tell Us about Code Changes

Written communications recorded through channels such as mailing lists or issue trackers, but also code co-changes, have been used to identify emerging collaborations in software projects. Also, such data has been used to identify the relation between developers' roles in communication networks and source code changes, or to identify mentors aiding newcomers to evolve the software project. However, results of such analyses may be different depending on the communication channel being mined. This paper investigates how collaboration links vary and complement each other when they are identified through data from three different kinds of communication channels, i.e., mailing lists, issue trackers, and IRC chat logs. Also, the study investigates how such links overlap with links mined from code changes, and how the use of different sources would influence (i) the identification of project mentors, and (ii) the presence of a correlation between the social role of a developer and her changes. Results of a study conducted on seven open source projects indicate that the overlap of communication links between the various sources is relatively low, and that the application of networks obtained from different sources may lead to different results.
Impact of cannabidiol on the acute memory and psychotomimetic effects of smoked cannabis: naturalistic study

Background The two main constituents of cannabis, cannabidiol and δ9-tetrahydrocannabinol (THC), have opposing effects both pharmacologically and behaviourally when administered in the laboratory. Street cannabis is known to contain varying levels of each cannabinoid. Aims To study how the varying levels of cannabidiol and THC have an impact on the acute effects of the drug in naturalistic settings. Method Cannabis users (n = 134) were tested 7 days apart on measures of memory and psychotomimetic symptoms, once while they were drug free and once while acutely intoxicated by their own chosen smoked cannabis. Using an unprecedented methodology, a sample of cannabis (as well as saliva) was collected from each user and analysed for levels of cannabinoids. On the basis of highest and lowest cannabidiol content of cannabis, two groups of individuals were directly compared. Results Groups did not differ in the THC content of the cannabis they smoked. Unlike the marked impairment in prose recall of individuals who smoked cannabis low in cannabidiol, participants smoking cannabis high in cannabidiol showed no memory impairment. Cannabidiol content did not affect psychotomimetic symptoms, which were elevated in both groups when intoxicated. Conclusions The antagonistic effects of cannabidiol at the CB1 receptor are probably responsible for its profile in smoked cannabis, attenuating the memory-impairing effects of THC. In terms of harm reduction, users should be made aware of the higher risk of memory impairment associated with smoking low-cannabidiol strains of cannabis like ‘skunk’ and encouraged to use strains containing higher levels of cannabidiol.
Intratumor heterogeneity and branched evolution revealed by multiregion sequencing.

BACKGROUND Intratumor heterogeneity may foster tumor evolution and adaptation and hinder personalized-medicine strategies that depend on results from single tumor-biopsy samples. METHODS To examine intratumor heterogeneity, we performed exome sequencing, chromosome aberration analysis, and ploidy profiling on multiple spatially separated samples obtained from primary renal carcinomas and associated metastatic sites. We characterized the consequences of intratumor heterogeneity using immunohistochemical analysis, mutation functional analysis, and profiling of messenger RNA expression. RESULTS Phylogenetic reconstruction revealed branched evolutionary tumor growth, with 63 to 69% of all somatic mutations not detectable across every tumor region. Intratumor heterogeneity was observed for a mutation within an autoinhibitory domain of the mammalian target of rapamycin (mTOR) kinase, correlating with S6 and 4EBP phosphorylation in vivo and constitutive activation of mTOR kinase activity in vitro. Mutational intratumor heterogeneity was seen for multiple tumor-suppressor genes converging on loss of function; SETD2, PTEN, and KDM5C underwent multiple distinct and spatially separated inactivating mutations within a single tumor, suggesting convergent phenotypic evolution. Gene-expression signatures of good and poor prognosis were detected in different regions of the same tumor. Allelic composition and ploidy profiling analysis revealed extensive intratumor heterogeneity, with 26 of 30 tumor samples from four tumors harboring divergent allelic-imbalance profiles and with ploidy heterogeneity in two of four tumors. CONCLUSIONS Intratumor heterogeneity can lead to underestimation of the tumor genomics landscape portrayed from single tumor-biopsy samples and may present major challenges to personalized-medicine and biomarker development. Intratumor heterogeneity, associated with heterogeneous protein function, may foster tumor adaptation and therapeutic failure through Darwinian selection. (Funded by the Medical Research Council and others.).
Characterization of chemically modified sawdust-reinforced recycled polyethylene composites

Chemically treated sawdust-reinforced recycled polyethylene composites were fabricated by the injection molding method, and the effect of fiber treatment on the physicomechanical properties of the composites were examined. Upon treatment with sodium hydroxide and benzoyl chloride, the hydrophilic nature of sawdust was significantly reduced. The physical properties of the composites such as water absorption, thickness swelling, and biodegradation behavior revealed that upon fiber surface modification, the composites have attained significant resistance to moisture absorption and microbial attacks. The mechanical properties of the chemically treated sawdust-reinforced composites were found to be improved compared to those of the untreated ones, suggesting that better fiber–matrix interfacial adhesion has occurred upon treatment of sawdust. This was further supported by surface morphology of the tensile-fractured surfaces of the composites captured by scanning electron microscopy that showed much less microvoids and interfacial flaws compared to those of the untreated ones.
Cyclophosphamide versus etoposide in combination with total body irradiation as conditioning regimen for adult patients with Ph‐negative acute lymphoblastic leukemia undergoing allogeneic stem cell transplant: On behalf of the ALWP of the European Society for Blood and Marrow Transplantation

Allogeneic hematopoietic cell transplantation (alloHCT) with myeloablative conditioning based on total body irradiation (TBI) is widely used for the treatment of adults with acute lymphoblastic leukemia (ALL). TBI is most frequently administered in combination with either cyclophosphamide (Cy/TBI) or etoposide (Vp/TBI). The goal of this study was to retrospectively compare these two regimens. Adult patients with Ph‐negative ALL treated with alloHCT in first or second complete remission who received Cy/TBI (n = 1346) or Vp/TBI (n = 152) conditioning were included in the analysis. In a univariate analysis, as compared to Cy/TBI, the use of Vp/TBI was associated with reduced incidence of relapse (17% vs. 30% at 5 years, P = .007), increased rate of leukemia‐free survival (60% vs. 50%, P = .04), and improved “graft versus host disease (GVHD) and relapse‐free survival” (GRFS, 43% vs. 33%, P = .04). No significant effect could be observed in terms of the incidence of nonrelapse mortality or acute or chronic GVHD. In a multivariate model, the use of Vp/TBI was associated with reduced risk of relapse (HR = 0.62, P = .04) while the effect on other study end‐points was not significant. In conclusion, conditioning regimen based on Vp combined with TBI appears more effective for disease control than the combination of Cy with TBI for adult patients with Ph‐negative ALL treated with alloHCT.
Oral administration of arabinogalactan affects immune status and fecal microbial populations in dogs.

Seven ileally cannulated dogs were randomly assigned to a control or arabinogalactan (AG) treatments in a 7 x 7 Latin square design to evaluate effects of oral AG administration on nutritional and immunological characteristics. Arabinogalactan treatments included a high (1.65 g/d) and low (0.55 g/d) dose of AG100, AG1000 or AG3000 provided via gelatin capsules. Arabinogalactan forms differed in purification procedures. Each period consisted of a 6-d adaptation followed by a 4-d collection. Blood and fresh fecal samples were collected on d 10 of each period. Fecal score increased (P < 0.02) in dogs supplemented with the low dose of AG1000. Ileal and total tract dry matter (DM) and organic matter (OM) digestibilities were not affected by treatment. Dogs supplemented with the high dose of AG1000 tended (P = 0.15) to have a higher concentration of total aerobic fecal bacteria than control dogs. Dogs supplemented with the low dose of AG1000 and the high dose of AG3000 had higher concentrations of fecal lactobacilli (P = 0.04) and tended to have higher concentrations of fecal bifidobacteria (P < or =0.16) compared with control dogs. Dogs fed the low dose of AG3000 tended (P = 0.10) to have a lower concentration of fecal Clostridium perfringens compared with control dogs. Arabinogalactan treatments did not affect (P > 0.05) serum immunoglobulin G, M or A concentrations. Specific forms and doses of AG increased white blood cell, neutropil and eosinophil concentrations. Arabinogalactan is a unique dietary fiber that affects the digestive physiology and immunological characteristics of dogs.
Total hip replacement in three cats: surgical technique, short-term outcome and comparison to femoral head ostectomy

Summary Objective: To describe the surgical technique and clinical features of total hip replacement (THR) due to hip trauma in cats. Study design: Retrospective study. Sample population: Three client-owned cats that underwent THR to treat capital epiphyseal fractures, and five client-owned cats that underwent femoral head ostectomy (FHO). Methods: The clinical data included signalment, body weight, body condition score, diagnosis, implant size, surgical technique, intraoperative observations, and postoperative complications. Radiographic evaluation included implant positioning, cement mantle quality, and follow-up examination of the cement-bone interfaces. Orthopaedic examinations and client interviews were used to evaluate limb function. Results: The three cats that underwent THR had a mean body weight of 5.5 kg, a mean body condition score of 6/9, and a mean age of three years at the time of surgery. The average THR follow-up was 11 months. For the five cats that underwent FHO, the mean body weight was 6.3 kg, mean body score was 7/9, and mean age at the time of FHO was 2.5 years. The average FHO follow-up was 22 months. Hip flexion, hip extension, and thigh girth after THR compared favourably to similar measurements made after FHO. The functional outcomes after THR were excellent. The functional outcomes after FHO ranged from poor to excellent. Conclusion and clinical relevance: The recovery after THR was excellent based on clinical assessment of muscle mass, hip joint passive range of motion, gait, and owner assessment. Further blinded, randomised, and controlled trials of THR in cats are warranted.
Are children safe indoor from outdoor air pollution? A short review

Background: Air pollution is a serious threat to children health. Given that children spend over 80% of their time indoors, understanding transport of pollutants from outdoor to indoor environments is important for assessing the impact of exposure to outdoor pollution on children health. The most common advice given during a smoke pollution episode is to stay indoors. How well this works depends on how clean the indoor air is and how pollutants from outdoor air contribute to pollutants load in indoor air. Objective: To assess the amount of outdoor air pollution coming indoors threatening children health. Methods: A Medline/EMBASE search of scientific articles was performed to evaluate the indoor-to-outdoor (I/O) concentration ratios of two main pollutants: ultrafine particles (UFP) and ozone (O3). Result: Under infiltration condition, the highest I/O ratios (0.6 - 0.9) were usually observed for larger UFP (70 - 100 nm), while the lowest I/O ratios (0.1 - 0.4) occurred typically around 10 - 20 nm. O3 I/O ratios vary according to air exchange and may be 0.6 - 0.8 for interiors having a large volume exchange with outdoor air (i.e. open windows) and 0.3 - 0.4 with conventional air conditioning systems. Conclusions: In the absence of indoor sources or activities, indoor UFP particles originate from outdoors. O3 concentration indoors may reach concentration similar to outdoors. Environmental and energy policies must also explicitly account for all the impacts of fossil fuel combustion on child health and development.
Enhanced semiconductor optical absorption via surface plasmon excitation in metal nanoparticles

Surface plasmon resonances in metallic nanoparticles are of interest for a variety of applications due to the large electromagnetic field enhancement that occurs in the vicinity of the metal surface, and the dependence of the resonance wavelength on the nanoparticle’s size, shape, and local dielectric environment. Here we report an engineered enhancement of optical absorption and photocurrent in a semiconductor via the excitation of surface plasmon resonances in spherical Au nanoparticles deposited on the semiconductor surface. The enhancement in absorption within the semiconductor results in increased photocurrent response in Si pn junction diodes over wavelength ranges that correspond closely to the nanoparticle plasmon resonance wavelengths as determined by measurements of extinction spectra. These observations suggest a variety of approaches for improving the performance of devices such as photodetectors, imaging arrays, and photovoltaics.
PHARMACOGNOSTIC AND PRELIMINARY PHYTOCHEMICAL INVESTIGATIONS OF ANACARDIUM OCCIDENTALE (LINN.) LEAVES Research Article

The present paper attempts to evaluate the physicochemical and preliminary phytochemical characteristics of Anacardium occidentale (Linn.), belonging to family Anacardiaceae. Anacardium occidentale is a tree native to Brazil and also found in tropical countries like Malaysia and India. The plant is reported to have anti-fungal, antioxidant and anti-inflammatory activities. However there are no reports for the detailed standardization of leaves. Hence a detailed study of the phytochemical and pharmacognostical parameters has been carried out. The macroscopic, microscopic characteristics of Cashew leaves were identified and physicochemical parameters were studied. Phytochemical tests reveal the presence of carbohydrates, proteins, saponin glycosides, flavonoids, alkaloids, tannins and phenolic compounds in ethanol and aqueous extract of leaves. TLC analysis was performed in order to obtain a fingerprint and identify various phytoconstituents present in the extracts. TLC of the ethanol extract was developed in the mobile phase of toluene:ethyl acetate:MeOH:formic acid (6:6:1:0.1v/v/v/v) and derivatisation with FeCl 3 The study reveals specific identification characteristics for the particular crude drug which will be of significant use in identification and control to adulterations of the raw drug and can serve as a reference for any further investigations. solution revealed the presence of tannins and phenols which gave a bluish black coloration.
Geriatric Nutritional Risk Index: a new index for evaluating at-risk elderly medical patients.

BACKGROUND Patients at risk of malnutrition and related morbidity and mortality can be identified with the Nutritional Risk Index (NRI). However, this index remains limited for elderly patients because of difficulties in establishing their normal weight. OBJECTIVE Therefore, we replaced the usual weight in this formula by ideal weight according to the Lorentz formula (WLo), creating a new index called the Geriatric Nutritional Risk Index (GNRI). DESIGN First, a prospective study enrolled 181 hospitalized elderly patients. Nutritional status [albumin, prealbumin, and body mass index (BMI)] and GNRI were assessed. GNRI correlated with a severity score taking into account complications (bedsores or infections) and 6-mo mortality. Second, the GNRI was measured prospectively in 2474 patients admitted to a geriatric rehabilitation care unit over a 3-y period. RESULTS The severity score correlated with albumin and GNRI but not with BMI or weight:WLo. Risk of mortality (odds ratio) and risk of complications were, respectively, 29 (95% CI: 5.2, 161.4) and 4.4 (95% CI: 1.3, 14.9) for major nutrition-related risk (GNRI: <82), 6.6 (95% CI: 1.3, 33.0), 4.9 (95% CI: 1.9, 12.5) for moderate nutrition-related risk (GNRI: 82 to <92), and 5.6 (95% CI: 1.2, 26.6) and 3.3 (95% CI: 1.4, 8.0) for a low nutrition-related risk (GNRI: 92 to < or =98). Accordingly, 12.2%, 31.4%, 29.4%, and 27.0% of the 2474 patients had major, moderate, low, and no nutrition-related risk, respectively. CONCLUSION GNRI is a simple and accurate tool for predicting the risk of morbidity and mortality in hospitalized elderly patients and should be recorded systematically on admission.
Consumption of one egg per day increases serum lutein and zeaxanthin concentrations in older adults without altering serum lipid and lipoprotein cholesterol concentrations.

Lutein and zeaxanthin accumulate in the macular pigment of the retina, and are associated with a reduced incidence of macular degeneration. The objective of the study was to investigate the effect of consuming 1 egg/d for 5‐wk on the serum concentrations of lutein, zeaxanthin, lipids and lipoprotein cholesterol in individuals greater than 60 y of age. In a randomized , cross‐over design, 33 subjects participated in the 18‐wk study, which included one run‐in and one washout period of no eggs prior to and between two five‐wk interventions of either consuming one egg or egg substitute/d. Serum lutein (26%) and zeaxanthin (38%) concentrations increased significantly after 5‐wk of 1 egg/d compared to the phase prior to consuming eggs. Serum concentrations of total cholesterol, LDL‐C, HDL‐C and triglycerides were not affected. These findings indicate that in older adults, 5 wk of consuming 1 egg/d significantly increases serum lutein and zeaxanthin concentrations without elevating serum lipids and lipoprotein cholesterol concentrations.
Dairy, calcium, and vitamin D intakes and prostate cancer risk in the National Health and Nutrition Examination Epidemiologic Follow-up Study cohort.

BACKGROUND Dairy intake may increase prostate cancer risk, but whether this is due to calcium's suppression of circulating vitamin D remains unclear. Findings on calcium and vitamin D intake and prostate cancer are inconsistent. OBJECTIVE We examined the association of dairy, calcium, and vitamin D intake with prostate cancer. DESIGN In a prospective study of 3612 men followed from 1982-1984 to 1992 for the first National Health and Nutrition Examination Epidemiologic Follow-up Study, 131 prostate cancer cases were identified. Dietary intake was estimated from questionnaires completed in 1982-1984. Relative risk (RR) and 95% CIs were estimated by using Cox proportional hazards models adjusted for age, race, and other covariates. RESULTS Compared with men in the lowest tertile for dairy food intake, men in the highest tertile had a relative risk (RR) of 2.2 (95% CI: 1.2, 3.9; trend P = 0.05). Low-fat milk was associated with increased risk (RR = 1.5; 95% CI: 1.1, 2.2; third compared with first tertile; trend P = 0.02), but whole milk was not (RR = 0.8; 95% CI: 0.5, 1.3; third compared with first tertile; trend P = 0.35). Dietary calcium was also strongly associated with increased risk (RR = 2.2; 95% CI: 1.4, 3.5; third compared with first tertile; trend P = 0.001). After adjustment for calcium intake, neither vitamin D nor phosphorus was clearly associated with risk. CONCLUSIONS Dairy consumption may increase prostate cancer risk through a calcium-related pathway. Calcium and low-fat milk have been promoted to reduce risk of osteoporosis and colon cancer. Therefore, the mechanisms by which dairy and calcium might increase prostate cancer risk should be clarified and confirmed.