Miracle-dz/UniFAR-FTUs huggingface dataset:
Narrowing the Gap: Effects of a Two-Way Bilingual Education Program on the Literacy Development of At-Risk Primary Students

Children with limited English proficiency are known to be at higher risk of school failure than their peers. Risk starts early, and the achievement lag of these children often widens with age and progression in the educational system. This study attempted to determine the effects of a 2-way bilingual education program on the literacy development of at-risk kindergarten students who had lower English proficiency and were in a higher failure risk bracket than a comparison group who had higher initial English competence and participated in regular education. Students in the experimental group were instructed in English approximately 70% of the time and in Spanish approximately 30% of the time. At the end of the 1st grade, no statistically significant differences were found between the 2 groups on the Scholastic Reading Inventory (SRI) or a combination of 6 other indicators of English literacy development.
Local Delivery of Autologous Platelet in Collagen Matrix Simulated in Situ Articular Cartilage Repair

Bone marrow released by microfracture or full-thickness cartilage defect can initiate the in situ cartilage repair. However, it can only repair small cartilage defects (<2 cm2). This study aimed to investigate whether autologous platelet-rich plasma (PRP) transplantation in collagen matrix can improve the in situ bone marrow-initiated cartilage repair. Full-thickness cartilage defects (diameter 4 mm, thickness 3 mm) in the patellar grooves of male New Zealand White rabbits were chosen as a model of in situ cartilage repair. They were treated with bilayer collagen scaffold (group II), PRP and bilayer collagen scaffold (group III), and untreated (group I), respectively (n = 11). The rabbits were sacrificed at 6 and 12 weeks after operation. The repaired tissues were processed for histology and for mechanical test. The results showed that at both 6 and 12 weeks, group III had the largest amounts of cartilage tissue, which restored a larger surface area of the cartilage defects. Moreover, group III had higher histological scores and more glycosaminoglycans (GAGs) content than those in the other two groups (p < 0.05). The Young's modulus of the repaired tissue in group II and group III was higher than that of group I (p < 0.05). Autologous PRP and bilayer collagen matrix stimulated the formation of cartilage tissues. The findings implicated that the combination of PRP with collagen matrix may repair larger cartilage defects that currently require complex autologous chondrocyte implantation (ACI) or osteochondral grafting.
The Moderating Effect of Neutralization Technique on Organizational Justice and Cyberloafing

While the advent of technology has revolutionized how businesses operate and how work is done, it has also opened up new avenues and opportunities for individuals to misbehave. This study focused on cyberloafing—the act of employees using their companies’ Internet access for personal purposes during work hours. Using the theoretical framework offered by research on neutralization techniques, we developed a model which suggested that when individuals perceived their organizations to be distributively, procedurally and interactionally unjust, they were likely to invoke the metaphor of the ledger as a neutralization technique to legitimize their subsequent engagement in the act of cyberloafing. Data were collected with the use of an electronic questionnaire and focus group interviews from 188 working adults with access to the Internet at the workplace. Results of moderated regression analyses empirical support for all of our hypotheses. Implications of our findings for organizational Internet policies are discussed.
Job involvement, job satisfaction, and organizational commitment: Predicting propensity to leave a job among skilled employee

This paper examines the impact of job involvement, job satisfaction and organizational commitment on propensity to leave a job. Using a stratified random sampling procedure, survey questionnaires are administered to 116 Information Systems (IS) personnel working in multinational companies in Malaysia. Results show that IS personnel's job involvement is positively associated with organizational commitment. Likewise, job satisfaction has a positive relationship on organizational commitment. Employees' organizational commitment also significantly influences their propensity to leave a job. The findings of this study are discussed in the light of previous evidence. This paper concludes with a discussion of implications and directions for future studies for IS research.
Sympatric speciation revealed by genome-wide divergence in the blind mole rat Spalax

Significance Sympatric speciation is still highly controversial. Here we demonstrate, based on genome-wide divergence analysis, that sympatric speciation in the blind subterranean rodent Spalax galili encompasses multiple and widespread genomic adaptive complexes associated with the sharply divergent and abutting basalt and chalk soil populations. Gene ontology enrichment analysis highlights sensory perception, musculature, metabolism, and energetics in basalt against neurogenetics and nutrition in chalk. Population divergence of chemoreceptor genes suggests the operation of mate and habitat choices, substantiating sympatric speciation. Natural selection and natural genetic engineering overrule gene flow, evolving divergent ecological adaptive complexes. Sympatric speciation may be a common speciation mode, as envisaged by Darwin, due to the abundance of sharp divergent geological, edaphic, climatic, and biotic ecologies in nature. Sympatric speciation (SS), i.e., speciation within a freely breeding population or in contiguous populations, was first proposed by Darwin [Darwin C (1859) On the Origins of Species by Means of Natural Selection] and is still controversial despite theoretical support [Gavrilets S (2004) Fitness Landscapes and the Origin of Species (MPB-41)] and mounting empirical evidence. Speciation of subterranean mammals generally, including the genus Spalax, was considered hitherto allopatric, whereby new species arise primarily through geographic isolation. Here we show in Spalax a case of genome-wide divergence analysis in mammals, demonstrating that SS in continuous populations, with gene flow, encompasses multiple widespread genomic adaptive complexes, associated with the sharply divergent ecologies. The two abutting soil populations of S. galili in northern Israel habituate the ancestral Senonian chalk population and abutting derivative Plio-Pleistocene basalt population. Population divergence originated ∼0.2–0.4 Mya based on both nuclear and mitochondrial genome analyses. Population structure analysis displayed two distinctly divergent clusters of chalk and basalt populations. Natural selection has acted on 300+ genes across the genome, diverging Spalax chalk and basalt soil populations. Gene ontology enrichment analysis highlights strong but differential soil population adaptive complexes: in basalt, sensory perception, musculature, metabolism, and energetics, and in chalk, nutrition and neurogenetics are outstanding. Population differentiation of chemoreceptor genes suggests intersoil population's mate and habitat choice substantiating SS. Importantly, distinctions in protein degradation may also contribute to SS. Natural selection and natural genetic engineering [Shapiro JA (2011) Evolution: A View From the 21st Century] overrule gene flow, evolving divergent ecological adaptive complexes. Sharp ecological divergences abound in nature; therefore, SS appears to be an important mode of speciation as first envisaged by Darwin [Darwin C (1859) On the Origins of Species by Means of Natural Selection].
Political Communication Faces the 21st Century

The study of political communication has come a long way. If we take Aristotle's Rhetoric and Politics written in 350 B.C. as a starting point, political messages have been noted, dissected, and speculated about for well over 2,000 years. So where are we now, in the 21st century of the Christian era, and where should we be heading?
Time on Task: A Naturalistic Study in Sixth-Grade Classrooms

1978 by The University of Chicago. 0013-5984/78/7803-0010$00.88 Pupils who fall behind their classmates academically fall further behind each year they remain in school (1). Part of the explanation for their continuing failure to keep pace with other pupils may lie in the fact that they spend less time on academic tasks than other pupils. The reason for such self-defeating behavior may be the desire to maintain self-esteem. If a pupil expends less effort on schoolwork than the average pupil, any resulting failure may be easier to accept. Pupils who try but fail may conclude that they do not have the ability to succeed. Pupils' involvement in tasks would seem to be a necessary condition for school achievement. If pupils are to master material, they must engage in it and react to it-read, make response. Indeed there are data to suggest that achievement is related to time for learning and opportunity to learn (2, 3). Similarly, there are data to suggest that learning is also positively related to low rates of time lost because of poor management of classrooms, for example, lengthy transitions (4). The major purpose of the present study was to find out whether pupil involvement was different for high, middle, and low achievers. Also, we wanted to find out whether pupils generally were more involved in some subjects than in others and whether certain types of classroom activities were associated with higher or with lower levels of pupil involvement. We selected two different types of schools to find out whether pupils' characteristics affect involvement. School 1
Several pathways of hydrogen peroxide action that damage the E. coli genome

Hydrogen peroxide is an important reactive oxygen species (ROS) that arises either during the aerobic respiration process or as a by-product of water radiolysis after exposure to ionizing radiation. The reaction of hydrogen peroxide with transition metals imposes on cells an oxidative stress condition that can result in damage to cell components such as proteins, lipids and principally to DNA, leading to mutagenesis and cell death. Escherichia coli cells are able to deal with these adverse events via DNA repair mechanisms, which enable them to recover their genome integrity. These include base excision repair (BER), nucleotide excision repair (NER) and recombinational repair. Other important defense mechanisms present in Escherichia coli are OxyR and SosRS anti-oxidant inducible pathways, which are elicited by cells to avoid the introduction of oxidative lesions by hydrogen peroxide. This review summarizes the phenomena of lethal synergism between UV irradiation (254 nm) and H2O2, the cross-adaptive response between different classes of genotoxic agents and hydrogen peroxide, and the role of copper ions in the lethal response to H2O2 under low-iron conditions.
Experimental evidence for English syllabification and syllable structure

Most phonologists regard the syllable as a unit of language. In recent years, partly in reaction to Chomsky's and Halle's neglect of it in The sound pattern of English, much work has been done to incorporate the syllable into phonological theory (Anderson & Jones, 1974; Bailey, 1978; Hoard, 1971; Hooper, 1972, 1974, 1976, 1978; Kahn, 1976; Pulgram, 1970; Rudes, 1977; Vennemann, 1972). Syllable theories have been based on evidence from phonetics, phonological processes, prosody, language change, child language acquisition, and language universals. The purpose of this experimental study is (a) to contribute empirical evidence about the nature of the syllable from native speakers' actual syllabifications of words and (b) to determine how this evidence reflects on the syllable theories already proposed. Syllable studies have focused on two major questions: (1) what is the structure of the syllable and (2) how are words divided into syllables (syllabified). These questions are obviously related, and the answers to each have implications for the other. This study was designed to elicit data directly addressing both questions.
Who Sets the Agenda

This study examines four models of a two-step flow of the agenda-setting process, highlighting the role played by certain individuals (early recognizers) in mediating between the public and the media. The data sets contained coding of news items on the major German television networks from 1990 to 1993 and 28 surveys conducted in West and East Germany between September 1990 and December 1992, sampling over 1,000 individuals in each survey to study the public agenda. The findings highlight the role of early recognizers, not only in identifying emerging issues in the media and diffusing them among the public but also in affecting the media agenda. The study's important contribution lies in identifying the flow of issues from the public to the media and within the public, thus reviving, to some extent, the notion of the two-step flow of communication.
T Cell–Specific Notch Inhibition Blocks Graft-versus-Host Disease by Inducing a Hyporesponsive Program in Alloreactive CD4+ and CD8+ T Cells

Graft-versus-host disease (GVHD) induced by donor-derived T cells remains the major limitation of allogeneic bone marrow transplantation (allo-BMT). We previously reported that the pan-Notch inhibitor dominant-negative form of Mastermind-like 1 (DNMAML) markedly decreased the severity and mortality of acute GVHD mediated by CD4+ T cells in mice. To elucidate the mechanisms of Notch action in GVHD and its role in CD8+ T cells, we studied the effects of Notch inhibition in alloreactive CD4+ and CD8+ T cells using mouse models of allo-BMT. DNMAML blocked GVHD induced by either CD4+ or CD8+ T cells. Both CD4+ and CD8+ Notch-deprived T cells had preserved expansion in lymphoid organs of recipients, but profoundly decreased IFN-γ production despite normal T-bet and enhanced Eomesodermin expression. Alloreactive DNMAML T cells exhibited decreased Ras/MAPK and NF-κB activity upon ex vivo restimulation through the TCR. In addition, alloreactive T cells primed in the absence of Notch signaling had increased expression of several negative regulators of T cell activation, including Dgka, Cblb, and Pdcd1. DNMAML expression had modest effects on in vivo proliferation but preserved overall alloreactive T cell expansion while enhancing accumulation of pre-existing natural regulatory T cells. Overall, DNMAML T cells acquired a hyporesponsive phenotype that blocked cytokine production but maintained their expansion in irradiated allo-BMT recipients, as well as their in vivo and ex vivo cytotoxic potential. Our results reveal parallel roles for Notch signaling in alloreactive CD4+ and CD8+ T cells that differ from past reports of Notch action and highlight the therapeutic potential of Notch inhibition in GVHD.
Performing Identities in Speaking Tests: Co-Construction Revisited

Poststructuralist perspectives on the discursive construction of identity and critical approaches to linguistics, discourse analysis, and language testing have contributed to a growing awareness of the complex social nature of performance in speaking tests. In this article, I explore how the concept of co-construction is useful to understand how candidate and interviewer identities are created in the discourse of speaking tests but argue for an expanded notion of co-construction that draws upon the concept of intertextuality to recognise the myriad of other ‘voices’, representing those who craft the tests, are interwoven into the discourses produced. The study adopts a qualitative approach, drawing upon discourse analysis to examine co-construction and intertextuality in two levels of Cambridge speaking tests. The findings reveal how interviewers and candidates co-construct particular identities through their interaction with each other, the interlocutor frame, and the test materials, and this can account for variability in performance, which is relevant to assessment. The key implications of the analysis for test preparation, interlocutor training, and speaking test development are also discussed.
Comparing the responses of maritally violent and nonviolent spouses to problematic marital and nonmarital situations: Are the skill deficits of physically aggressive husbands and wives global?

This study compared the competency of responses offered by spouses in violent and nonviolent marriages to problematic marital and nonmarital situations. Twenty-five maritally violent and distressed, 10 nonviolent but maritally distressed, and 23 nonviolent and nondistressed couples participated. Each spouse listened to narrations of marital and nonmarital (e.g., boss or friend) problematic situation vignettes. Participants were asked what they would say and do in each situation. A coding system designed with input from nonviolent, happily married individuals showed that violent spouses provided less competent responses than nonviolent spouses for both marital and nonmarital situations and for both 1st and 2nd responses. The findings suggest that violent-distressed spouses have particular difficulty with marital situations.
Molecular Characterization and Clinical Impact of TMPRSS2-ERG Rearrangement on Prostate Cancer: Comparison between FISH and RT-PCR

Prostate cancer (PCa) is a very heterogeneous disease, and there are constraints in its current diagnosis. Serum PSA levels, digital rectal examination (DRE), and histopathologic analysis often drive to overdiagnosis and overtreatment. Since 2005, the presence of the genetic rearrangement between transmembrane-serine protease gene (TMPRSS2) and the erythroblast transformation-specific (ETS) member ERG (v-ets erythroblastosis virus E26 oncogene homolog avian) has been demonstrated in almost half of PCa cases. Both FISH and RT-PCR are useful tools for detecting these rearrangements, but very few comparatives between both techniques have been published. In this study, we included FFPE tumors from 294 PCa patients treated with radical prostatectomy with more than 5 years of followup. We constructed a total of 20 tissue microarrays in order to perform break-apart and tricolor probe FISH approaches that were compared with RT-PCR, showing a concordance of 80.6% (P < 0.001). The presence of TMPRSS2-ERG rearrangement was observed in 56.6% of cases. No association between TMPRSS2-ERG status and clinicopathological parameters nor biochemical progression and clinical progression free survival was found. In conclusion, this study demonstrates that both FISH and RT-PCR are useful tools in the assessment of the TMPRSS2-ERG fusion gene status in PCa patients and that this genetic feature per se lacks prognostic value.
Pups and Babes: Quantifying Sources of Difference in Emotional and Behavioral Reactions to Accounts of Human and Animal Abuse

ABSTRACT Anecdotal reports suggest that people may be affected more by media coverage of animal rather than human-related abuse. Findings of the extant research regarding this apparent effect are mixed and omit certain key variables that may drive differential reactions to abuse disclosure. The goal of the current study was therefore to examine whether differences exist between individuals' emotional responses and pro-social behavior (reporting abuse) with respect to human (infant), or animal (puppy), directed abuse, and the effect of demographic and personality variables (including empathy and attitude to animals) on these responses. One hundred and twenty-three university students (104 females, 19 males) were presented with two scenarios (randomly presented to control for order effects) describing identical abuse situations but with two different “victims”—namely an infant or a puppy. Immediately after reading each scenario they were asked to indicate how much what the infant/puppy went through “bothered” them, the likelihood of their contacting the police should they know or discover the identity of the attacker, and complete the Profile of Mood States (Short Form). Results indicated that although in general participants were more bothered by the infant-than the puppy-abuse scenario, this was mediated by whether participants were current pet owners, and their level of pet attachment. Specifically, those most attached to their pet were significantly more bothered by the puppy abuse scenario than any other group. Personality and demographic characteristics were also found to relate to mood disturbance, bother rating, and willingness to contact police following each scenario.
`Human clones talk about their lives': media representations of assisted reproductive and biogenetic technologies

This article examines New Zealand print media representations of assisted reproductive and related biogenetic technologies, conceptualized as the products of a concordance of interest between media workers and reproductive specialists, biogenetic scientists and consumers. Such concordance is evident in the predominant use of media frames of anecdotal personalization and technoboosterism, which typically amplify the voices of proponents of emerging technologies while marginalizing and delegitimizing counterdiscourses. Thus, the perspectives of consumers and ‘expert’ sources are privileged at the expense of a more balanced assessment of the value and social, ethical, legal and health implications of assisted reproductive and related biogenetic technologies. Source dependence also detracts from much-needed recognition of the professional and financial interests at stake in the growing privatization and commercialization of these technologies, and in the local context potentially undermines journalistic independence and integrity.
Role of serotonergic and noradrenergic systems in the pathophysiology of depression and anxiety disorders

There is abundant evidence for abnormalities of the norepinephrine (NE) and serotonin (5HT) neurotransmitter systems in depression and anxiety disorders. The majority of evidence supports underactivation of serotonergic function and complex dysregulation of noradrenergic function, most consistent with overactivation of this system. Treatment for these disorders requires perturbation of these systems. Reproducible increases in serotonergic function and decreases in noradrenergic function accompany treatment with antidepressants, and these alterations may be necessary for antidepressant efficacy. Dysregulation of these systems clearly mediates many symptoms of depression and anxiety. The underlying causes of these disorders, however, are less likely to be found within the NE and 5HT systems, per se. Rather their dysfunction is likely due to their role in modulating, and being modulated by, other neurobiologic systems that together mediate the symptoms of affective illness. Clarification of noradrenergic and serotonergic modulation of various brain regions may yield a greater understanding of specific symptomatology, as well as the underlying circuitry involved in euthymic and abnormal mood and anxiety states. Disrupted cortical regulation may mediate impaired concentration and memory, together with uncontrollable worry. Hypothalamic abnormalities likely contribute to altered appetite, libido, and autonomic symptoms. Thalamic and brainstem dysregulation contributes to altered sleep and arousal states. Finally, abnormal modulation of cortical‐hippocampal‐amygdala pathways may contribute to chronically hypersensitive stress and fear responses, possibly mediating features of anxiety, anhedonia, aggression, and affective dyscontrol. The continued appreciation of the neural circuitry mediating affective states and their modulation by neurotransmitter systems should further the understanding of the pathophysiology of affective and anxiety disorders. Depression and Anxiety, Volume 12, Supplement 1:2–19, 2000. © 2000 Wiley‐Liss, Inc.