Miracle-dz/UniFAR-FTUs huggingface dataset:
A shift to a peripheral Th2-type cytokine pattern during the carcinogenesis of cervical cancer becomes manifest in CIN III lesions

Background: A shifted balance between T helper 1 (Th1)-type and Th2-type cytokines has been hypothesised in cervical dysplasia Aims: To evaluate possible deregulation of the cytokine network by estimating the expression of peripheral cytokines in different stages of cervical disease and in relation to the presence or absence of high risk human papillomavirus (HR-HPV). Methods: Twenty one HR-HPV positive women with high grade cervical intraepithelial neoplasia (CIN II–III) and 12 patients with invasive cervical carcinoma formed the study groups. Two control groups consisted of 10 HR-HPV positive and 11 HR-HPV negative women without CIN. Differences in leucocyte subgroups were evaluated by a differential leucocyte count. Plasma concentrations of tumour necrosis factor α (TNFα), TNFα receptors TNFRI and TNFRII, interferon γ (IFNγ), interleukin 2 (IL-2), IL-12, IL-4, and IL-10 were determined by enzyme linked immunosorbent assays. Results: Leucocyte counts in patients with CIN III and carcinoma were significantly higher than in controls. Plasma IFNγ concentrations were significantly lower in patients with CIN III and carcinoma than in women with CIN II or controls. Plasma concentrations of IL-12, IL-2, IL-4, and TNFα did not differ significantly between groups, but significantly lower plasma concentrations of TNFRII were found in CIN III and carcinoma compared with CIN II. IL-10 was detected with increased frequency in the plasma of patients with CIN III and carcinoma. Conclusions: These results indicate that a shift to a Th2-type cytokine pattern during the carcinogenesis of cervical cancer occurs in women with CIN III lesions.
Criminogenic Associations and Characteristic British Housing Designs

The perceptions of various crucial stakeholders in urban Britain, relating to the criminogenic capacity of a range of characteristic housing designs, are explored. Crime Prevention Through Environmental Design (CPTED) is an increasingly popular crime reduction strategy, based primarily upon Newman's 'defensible space' theory. However, this theory remains largely untested, and findings have been contradictory. CPTED responses are often based upon recorded crime statistics and this research challenges the use of such data in isolation. First, such data are empirically flawed and persistently misrepresent the reality of crime, and second, the recorded crime statistics are inappropriate for geographical comparisons at the micro scale. This culturally specific investigation seeks to explore the perceptions of three crucial user groups. The perceptions of town planners, police officers and convicted burglars are investigated with regard to various characteristic housing designs in Cardiff, Wales, to discover whether a commonality or plurality of perspectives exists. The ways in which different user groups perceive housing design can provide a framework for modifying future designs and may also have implications for housing allocation policies, policing and the layout of cities.
Pattern Mining of Multichannel sEMG for Tremor Classification

Tremor is defined as the involuntary rhythmic or quasi-rhythmic oscillation of a body part, resulting from alternating or simultaneous contractions of antagonistic muscle groups. While tremor may be physiological, those who have disabling pathological tremors find that performing typical activities for daily living to be physically challenging and emotionally draining. Detecting the presence of tremor and its proper identification are crucial in prescribing the appropriate therapy to lessen its deleterious physical, emotional, psychological, and social impact. While diagnosis relies heavily on clinical evaluation, pattern analysis of surface electromyogram (sEMG) signals can be a useful diagnostic aid for an objective identification of tremor types. Using sEMG system attached to several parts of the patient's body while performing several tasks, this research aims to develop a classifier system that automates the process of tremor types recognition. Finding the optimal model and its corresponding parameters is not a straightforward process. The resulting workflow, however, provides valuable information in understanding the interplay and impact of the different features and their parameters to the behavior and performance of the classifier system. The resulting model analysis helps identify the necessary locations for the placement of sEMG electrodes and relevant features that have significant impact in the process of classification. These information can help clinicians in streamlining the process of diagnosis without sacrificing its accuracy.
PENGARUH LOCUS OF CONTROL, SELF EFFICACY, DAN KOMITMEN PROFESSIONAL TERHADAP PERILAKU AUDITOR DALAM SITUASI KONFLIK AUDIT (SURVEY PADA KANTOR AKUNTAN PUBLIK DI KOTA BANDUNG, JAWA BARAT)

Penelitian ini bertujuan untuk menganalisis bagaimana pengaruh locus of control , self efficacy dan komitmen profesional terhadap perilaku auditor dalam situasi konflik audit. Penelitian ini menggunakan metode convenience sampling untuk memilih sampel. Sampel dalam penelitian ini adalah auditor yang bekerja pada Kantor Akuntan Publik (KAP) di Bandung. Data yang digunakan dalam penelitian ini data primer yaitu kuesioner yang disampaikan secara langsung kepada auditor oleh peneliti sebanyak 50 kuesioner dan yang dapat diolah hanya 44 kuesioner. Alat uji yang digunakan untuk menganalisis data adalah pengujian validitas, pengujian reliabilitas, uji asumsi klasik, uji regresi linier dan uji korelasi dengan bantuan program SPSS 17.0 ( Statistical Product and Service Solutions ). Hasil penelitian menunjukan bahwa terdapat pengaruh dan signifikan antara Locus of Control, Self Efficacy, dan Komitmen Profesional terhadap perilaku auditor dalam situasi konflik audit. Secara parsial terhadap locus of control , sifat machiavellian, dan komitmen profesi, mempunyai pengaruh yang signifikan pada perilaku auditor dalam situasi konflik yaitu sebesar 0.026, 0.409, 0.319 Kata kunci : Locus of Control , Self Efficacy , Komitmen Profesional, Perilaku Auditor
About the calculation of exchange coupling constants in polynuclear transition metal complexes

The application of theoretical methods based on the density functional theory with hybrid functionals provides good estimates of the exchange coupling constants for polynuclear transition metal complexes. The accuracy is similar to that previously obtained for dinuclear compounds. We present test calculations on simple model systems based on H · · · He and CH2 · · · He units to compare with Hartree–Fock and multiconfigurational results. Calculations for complete, nonmodeled polynuclear transition metal complexes yield coupling constants in very good agreement with available experimental data. © 2003 Wiley Periodicals, Inc. J Comput Chem 24: 982–989, 2003
Closing the Loop: Modelling of Heart Failure Progression from Health to End-Stage Using a Meta-Analysis of Left Ventricular Pressure-Volume Loops

Introduction The American Heart Association (AHA)/American College of Cardiology (ACC) guidelines for the classification of heart failure (HF) are descriptive but lack precise and objective measures which would assist in categorising such patients. Our aim was two fold, firstly to demonstrate quantitatively the progression of HF through each stage using a meta-analysis of existing left ventricular (LV) pressure-volume (PV) loop data and secondly use the LV PV loop data to create stage specific HF models. Methods and Results A literature search yielded 31 papers with PV data, representing over 200 patients in different stages of HF. The raw pressure and volume data were extracted from the papers using a digitising software package and the means were calculated. The data demonstrated that, as HF progressed, stroke volume (SV), ejection fraction (EF%) decreased while LV volumes increased. A 2-element lumped parameter model was employed to model the mean loops and the error was calculated between the loops, demonstrating close fit between the loops. The only parameter that was consistently and statistically different across all the stages was the elastance (Emax). Conclusions For the first time, the authors have created a visual and quantitative representation of the AHA/ACC stages of LVSD-HF, from normal to end-stage. The study demonstrates that robust, load-independent and reproducible parameters, such as elastance, can be used to categorise and model HF, complementing the existing classification. The modelled PV loops establish previously unknown physiological parameters for each AHA/ACC stage of LVSD-HF, such as LV elastance and highlight that it this parameter alone, in lumped parameter models, that determines the severity of HF. Such information will enable cardiovascular modellers with an interest in HF, to create more accurate models of the heart as it fails.
The 'Big Five' Personality Variables--Construct Confusion: Description Versus Prediction

Personality researchers are converging on the Big Five personality constructs as a taxonomy for describing the basic dimensions of peasonality. If, however, ppre- diction rather than description is important, the Big Five may not be an adequate taxonomy. This article presents data that suggest the Big Five is not an adequate taxonomy of personality variables for predicting important criteria. The Big Five constructs are too heterogeneous and incomplete. A nine-factor taxonomy is pre- sented along with correlational evidence demonstrating differential prediction of criteria for each of the nine personality constructs.
Sedation and Analgesia-Prescribing Patterns in Terminally Ill Patients at the End of Life

The extensive use of sedative and analgesic medication at the end of life is often controversial due to the perception that death may be hastened as a result of progressive drug escalation. Physician attitudes toward prescribing medication in this setting vary, resulting in widely differing prescribing patterns for patients with advanced cancer. This investigation attempted to identify overall prescribing patterns and variation in the use of sedation and analgesia in an inpatient hospice setting at the end of life. A retrospective case review was undertaken of 102 consecutive patients who died in a palliative care hospice. A detailed review of medication prescription, with particular attention to sedation and analgesia in the last week of life, was performed. The review revealed that regular sedation was prescribed in 68 percent of the patients. Almost two-thirds of the patients began regular sedation on admission or within seven days of admission. Although survival was higher in patients who received regular sedation (mean, 36.5 days) versus those that did not (mean, 17 days), the difference was not significant (p = 0.1). Overall, regular sedation with moderate dose increases was observed. In patients prescribed morphine from the time of admission, morphine oral equivalents increased from a mean of 111 mg on admission to a mean of 346 mg at time of death for a mean escalation of 311 percent. The mean duration of admission was 26 days with an opioid-escalation index of 12 percent per day. Survival is a multifactorial phenomenon and was unrelated to the level of analgesia in this cohort. Findings showed that sedation dose increased modestly toward the end of life, and that the increase was not associated with a significant reduction in survival. Further, there was no significant impact on survival related to an individual physician's prescribing pattern at the end of life. These results suggest that, in the institution where the review was conducted, neither sedation nor individual variation in physician prescribing habits in terminally ill patients was associated with hastening of death. Overall, the amount of sedative drugs required for adequate symptom control during terminal care was moderate.
Noninvasive near-infrared fluorescent protein-based imaging of tumor progression and metastases in deep organs and intraosseous tissues

Abstract. Whole-body imaging of experimental tumor growth is more feasible within the near-infrared (NIR) optical window because of the highest transparency of mammalian tissues within this wavelength spectrum, mainly due to improved tissue penetration and lower autofluorescence. We took advantage from the recently cloned infrared fluorescent protein (iRFP) together with a human immunodeficiency virus (HIV)-based lentiviral vector to produce virally transduced tumor cells that permanently express this protein. We then noninvasively explored metastatic spread as well as primary tumor growth in deep organs and behind bone barriers. Intrabone tumor growth was investigated through intracranial and intratibial injections of glioblastoma and osteosarcoma cells, respectively, and metastasis was assessed by tail vein injection of melanoma cells. We found that the emitted fluorescence is captured as sharp images regardless of the organ or tissue considered. Furthermore, by overlaying fluorescence spots with the white light, it was possible to afford whole-body images yet never observed before. This approach allowed us to continuously monitor the growth and dissemination of tumor cells with a small number of animals, minimal animal handling, and without the need for any additive. This iRFP-based system provides high-resolution readouts of tumorigenesis that should greatly facilitate preclinical trials with anticancer therapeutic molecules.
Activation of hepatitis B virus S promoter by the viral large surface protein via induction of stress in the endoplasmic reticulum

Hepatitis B virus (HBV) codes for three forms of surface protein. The minor, large form is translated from transcripts specified by the preS1 promoter, while the middle and small forms are translated from transcripts specified by the downstream S promoter. When the large surface protein is overexpressed, the secretion of both subviral and virion particles is blocked within the secretory pathway. We show here that overexpression of the large surface protein leads to up to a 10-fold activation of the S promoter but not of an unrelated promoter. Neither the middle nor the small surface protein, nor a secretable form of the large surface protein, activates the S promoter, but agents that induce endoplasmic reticulum (ER) stress have an effect similar to that of the large surface protein. The large surface protein also activates the S promoter in the context of the entire viral genome. Therefore, it appears that HBV has evolved a feedback mechanism, such that ER stress induced by accumulation of the large surface protein increases the synthesis of the middle and small surface proteins, which in combination with the large surface protein can form mixed, secretable particles. In addition, like other agents that induce ER stress, the large surface protein can activate the cellular grp78 and grp94 promoters, raising the possibility that it may alter the physiology of the host cell.
Enhanced Strength and Sprint Levels, and Changes in Blood Parameters during a Complete Athletics Season in 800 m High-Level Athletes

The purpose of this study was to analyze changes in sprint, strength, hematological, and hormonal parameters in high-level 800 m athletes during a complete athletics season. Thirteen male athletes of national and international level in 800 m (personal best ranging from 1:43 to 1:58 min:ss) participated in this study. A total of 5 tests were conducted during a complete athletics season. Athletes performed sprint tests (20 and 200 m), countermovement jump (CMJ), jump squat (JS), and full squat (SQ) tests. Blood samples (red and white blood profile) and hormones were collected in test 1 (T1), test 3 (T3), and test 5 (T5). A general increase in the performance of the strength and sprint parameters analyzed (CMJ, JS, SQ, 20 m, and 200 m) during the season was observed, with a significant time effect in CMJ (P < 0.01), SQ (P < 0.01), and 200 m (P < 0.05). This improvement was accompanied by a significant enhancement of the 800 m performance from T3 to T5 (P < 0.01). Significant changes in some hematological variables: hematocrit (Hct) (P < 0.01), mean corpuscular volume (MCV) (P < 0.001), mean corpuscular hemoglobin content (MCHC) (P < 0.001), white blood cells count (WBC) (P < 0.05), neutrophils (P < 0.05), monocytes (P < 0.05), and mean platelet volume (MPV) (P < 0.05) were observed throughout the season. The hormonal response and creatin kinase (CK) did not show significant variations during the season, except for insulin-like growth factor I (IGF-1) (P < 0.05). In conclusion, our results suggest the importance of strength levels in middle-distance athletes. On the other hand, variations in some hematological parameters and a depression of the immune system occurred during the season. Therefore, monitoring of the mechanical, hematological and hormonal response in athletes may help coaches and athletes to optimize the regulation of training contents and may be useful to diagnose states of overreaching or overtraining in athletes throughout the season.
Risk Mechanisms in Hypertensive Heart Disease

Abstract —In this report, some of the underlying pathophysiological alterations associated with the independent risk from hypertensive heart disease and left ventricular hypertrophy are discussed. Emphasized are the classically described coronary hemodynamic alterations of decreased coronary blood flow and flow reserve with increased coronary vascular resistance and minimal coronary resistance; more recent concepts of endothelial dysfunction are emphasized. Additionally, increased collagen deposition within the ventricular walls and perivascularly participates importantly. These changes are exacerbated by the aging process and perhaps by increased dietary salt intake. Consequences of these functional and structural changes include further endothelial dysfunction, impairment of coronary hemodynamics, and ventricular contractile function (diastolic as well as systolic). The clinical consequences of these alterations are angina pectoris (with or without atherosclerosis), myocardial infarction, cardiac failure, lethal dysrhythmias, and sudden cardiac death. Thus, not all that is clinically recognized as “left ventricular hypertrophy” is true myocytic hypertrophy with structural remodeling; other important comorbid changes occur that directly affect risk, including ventricular fibrosis, impaired coronary hemodynamics, and endothelial dysfunction.
Does Delayed School Entry Reduce Later Grade Retentions and Use of Special Education Services?

The practice of delaying children's entry into a kindergarten program 1 year beyond the traditional chronolgical age of their classmates is a controversial issue. although this practice has been said to reduce the need for grade retentions and special education services, the research literature has yielded contradictory results about the effects of delayed entry on students. the present study examined the effects of delayed entry in one suburban new york school district on later elementaryschool grade retention and special education service rates. in addition, the influence of gender on the practice of delayed entry was investigated. the sample for this study consisted of all students (n = 3,238) who were enrolled in grades 1 through 12; from this, a subsample of all children (n = 279) who had delayed school entry were identified, and their records were examined for future retentions and use of special education services. it was found that students who delayed school entry were most often male and were placed in special education programs in significantly higher proportions than nondelayed-entry students. no significant effect of delayed entry was noted for retention.
Vitamin E dietary supplementation protects against carbon tetrachloride—induced chronic liver damage and cirrhosis

Previous studies have shown that α‐tocopherol (vitamin E) pretreatment of experimental animals can protect against acute liver necrosis induced by carbon tetrachloride. In this study we investigated whether the increase of vitamin E liver content by dietary supplementation influences chronic liver damage and cirrhosis induced by carbon tetrachloride in the rat. Our data indicate that vitamin E supplementation did not interfere with the growth rate of the animals and increased about threefold the liver's content of the vitamin. Vitamin E supplementation significantly reduced oxidative liver damage, but it was not effective in protecting against development of fatty liver and did not interfere with metabolic activation of carbon tetrachloride. Moreover, vitamin E—fed animals showed incomplete but significant prevention of liver necrosis and cirrhosis induced by carbon tetrachloride. This has been shown by means of histological examination, analysis of serum parameters and biochemical evaluation of collagen content. These results show that an increased liver content of vitamin E can afford a significant degree of protection against carbon tetrachloride–induced chronic liver damage and cirrhosis. (HEPATOLOGY 1992;16:1014–1021)
Individuella utvecklingsplaner för yngre barn i Sverige: Ett kritiskt ämnesdidaktiskt perspektiv

Individuella utvecklingsplaner for yngre barn i ett kritiskt amnes¬didaktiskt perspektiv Ann-Christine Vallberg Roth & Annika Mansson, Lararutbildningen, Malmo hogskola, 2007 Abstrakt Studien syftar till att beskriva och problematisera mal och innehall i individuella utvecklings¬planer (IUP) for forskole- och forskoleklassbarn i ett kritiskt amnes¬didaktiskt perspektiv. Individuella utvecklingsplaner ses som ett fenomen i fram¬vaxten av granskningssamhallet med trans¬nationell reglering. Centralt for analysen ar didaktikens vad-fraga som ror innehall (larandets objekt). Med amne avses konstruktionen av innehall och da inte enbart snavt i bemarkelsen skolamne utan ocksa amnes¬overskridande tematiskt och vardagligt knutet till omsorgs– och fostransinnehall och till barns mojliga fragor. Genom kritisk didaktik belyses relationerna mellan aktorerna (barn, vardnadshavare och larare) och deras med¬bestammande och inflytande. Samman¬taget innebar ett kritiskt amnes¬didaktiskt perspektiv att innehall studeras i forhallande till maktdimensionerna plats, alder kon och etnicitet – innehall pa en trans¬formerings¬arena i tid och rum mellan stat och individ. Insamlingen av IUP-materialet genomfordes i oktober 2006 i fyra kommuner i sodra Sverige, tre stadskommuner och en landsbygdskommun. I de tre stadskommunerna ingick bade etniskt relativt homogena och heterogena kommundelar. Materialet omfattade 82 slumpmassigt valda planer. Analysen kan summeras i tre utmarkande huvudspar eller normaliteter: • Skolamnesreglerade normalbarn – i relativt homogen stadskommundel • Socialt och ensprakigt reglerade multikulturella barn – i relativt heterogen stadskommundel • Primart behovsreglerade monokulturella barn – i landsbygdskommun