Miracle-dz/UniFAR-FTUs huggingface dataset:
Dietary sodium intake is associated with total fluid and sugar-sweetened beverage consumption in US children and adolescents aged 2-18 y: NHANES 2005-2008.

BACKGROUND Increasing dietary sodium drives the thirst response. Because sugar-sweetened beverages (SSBs) are frequently consumed by children, sodium intake may drive greater consumption of SSBs and contribute to obesity risk. OBJECTIVE We examined the association between dietary sodium, total fluid, and SSB consumption in a nationally representative sample of US children and adolescents aged 2-18 y. DESIGN We analyzed cross-sectional data from NHANES 2005-2008. Dietary sodium, fluid, and SSB intakes were assessed with a 24-h dietary recall. Multiple regression analysis was used to assess associations between sodium, fluid, and SSBs adjusted for age, sex, race-ethnic group, body mass index (BMI), socioeconomic status (SES), and energy intake. RESULTS Of 6400 participants, 51.3% (n = 3230) were males, and the average (±SEM) age was 10.1 ± 0.1 y. The average sodium intake was 3056 ± 48 mg/d (equivalent to 7.8 ± 0.1 g salt/d). Dietary sodium intake was positively associated with fluid consumption (r = 0.42, P < 0.001). After adjustment for age, sex, race-ethnic group, SES, and BMI, each additional 390 mg Na/d (1 g salt/d) was associated with a 74-g/d greater intake of fluid (P < 0.001). In consumers of SSBs (n = 4443; 64%), each additional 390 mg Na/d (1 g salt/d) was associated with a 32-g/d higher intake of SSBs (P < 0.001) adjusted for age, sex, race-ethnic group, SES, and energy intake. CONCLUSIONS Dietary sodium is positively associated with fluid consumption and predicted SSB consumption in consumers of SSBs. The high dietary sodium intake of US children and adolescents may contribute to a greater consumption of SSBs, identifying a possible link between dietary sodium intake and excess energy intake.
Surveillance cultures in healthcare-associated pneumonia: sense or nonsense?

Purpose of review This review explores the usefulness of surveillance cultures in healthcare-associated pneumonia (HCAP). Recent findings The definition of HCAP is controversial. Causative micro-organisms of HCAP resemble those found in hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP). Some types of surveillance cultures have proven useful in hospitalized patients. Whereas numerous studies have investigated the role of surveillance cultures in VAP, one may wonder whether surveillance culture implementation should belong in HCAP management guidelines. Summary Studies exploring the usefulness of obtaining surveillance cultures in VAP are numerous, but are mostly retrospective, observational and/or quasi-experimental in nature. Surveillance cultures may be useful for antibiotic guidance, but positive predictive value and specificity of surveillance cultures are low, obviously negatively impacting on cost effectiveness, especially in the large population at risk for HCAP. On the other hand, multidrug-resistance is increasing and surveillance cultures for methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci in ICU-admitted patients appeared useful and cost-effective. Furthermore, surveillance cultures for the presence of multidrug-resistant Gram-negative bacilli might be useful for antibiotic guidance. Currently, neither community-acquired pneumonia, HCAP, HAP nor VAP guidelines incorporate surveillance cultures. In the future, surveillance cultures in populations at risk for HCAP may be able to differentiate HCAP from other kinds of pneumonia and authorize its reason for existence.
Severe Embryotoxicity of Artemisinin Derivatives in Experimental Animals, but Possibly Safe in Pregnant Women

Preclinical studies in rodents have demonstrated that artemisinins, especially injectable artesunate, can induce fetal death and congenital malformations at a low dose range. The embryotoxicity can be induced in those animals only within a narrow window in early embryogenesis. Evidence was presented that the mechanism by which embryotoxicity of artemisinins occurs seems to be limited to fetal erythropoiesis and vasculogenesis/ angiogenesis on the very earliest developing red blood cells, causing severe anemia in the embryos with higher drug peak concentrations. However, this embryotoxicity has not been convincingly observed in clinical trials from 1,837 pregnant women, including 176 patients in the first trimester exposed to an artemisinin agent or artemisinin-based combination therapy (ACT) from 1989 to 2009. In the rodent, the sensitive early red cells are produced synchronously over one day with single or multiple exposures to the drug can result in a high proportion of cell deaths. In contrast, primates required a longer period of treatment of 12 days to induce such embryonic loss. In humans only limited information is available about this stage of red cell development; however, it is known to take place over a longer time period, and it may well be that a limited period of treatment of 2 to 3 days for malaria would not produce serious toxic effects. In addition, current oral intake, the most commonly used route of administration in pregnant women with an ACT, results in lower peak concentration and shorter exposure time of artemisinins that demonstrated that such a concentration–course profile is unlikely to induce the embryotoxicity. When relating the animal and human toxicity of artemisinins, the different drug sensitive period and pharmacokinetic profiles as reviewed in the present report may provide a great margin of safety in the pregnant women.
Query expansion using term relationships in language models for information retrieval

Language Modeling (LM) has been successfully applied to Information Retrieval (IR). However, most of the existing LM approaches only rely on term occurrences in documents, queries and document collections. In traditional unigram based models, terms (or words) are usually considered to be independent. In some recent studies, dependence models have been proposed to incorporate term relationships into LM, so that links can be created between words in the same sentence, and term relationships (e.g. synonymy) can be used to expand the document model. In this study, we further extend this family of dependence models in the following two ways: (1) Term relationships are used to expand query model instead of document model, so that query expansion process can be naturally implemented; (2) We exploit more sophisticated inferential relationships extracted with Information Flow (IF). Information flow relationships are not simply pairwise term relationships as those used in previous studies, but are between a set of terms and another term. They allow for context-dependent query expansion. Our experiments conducted on TREC collections show that we can obtain large and significant improvements with our approach. This study shows that LM is an appropriate framework to implement effective query expansion.
Pricing dynamics in the online consumer electronics market

This paper investigates prices of consumer electronics sold on the Web by both online‐only retailers (Dotcoms) and the online branches of multi‐channel retailers (MCRs). Surprisingly, it finds that Dotcoms charge higher price than MCRs, a conclusion contradictory to the results of most of empirical studies. Also finds that the electronics prices decreased over the period of study in general, dropping about 0.6 percent per week, and the prices of MCRs and Dotcoms went down with time at a similar speed. Further, the prices across MCRs are 35.3 percent more dispersed than the prices across the Dotcoms based on full prices, and 33.1 percent more dispersed based on percentage prices. However, results show that price dispersion moved up with time in general, with no significant difference in the speeds between MCRs and Dotcoms.
A Frame-Based Probabilistic Framework for Spoken Dialog Management Using Dialog Examples

This paper proposes a probabilistic framework for spoken dialog management using dialog examples. To overcome the complexity problems of the classic partially observable Markov decision processes (POMDPs) based dialog manager, we use a frame-based belief state representation that reduces the complexity of belief update. We also used dialog examples to maintain a reasonable number of system actions to reduce the complexity of the optimizing policy. We developed weather information and car navigation dialog system that employed a frame-based probabilistic framework. This framework enables people to develop a spoken dialog system using a probabilistic approach without complexity problem of POMDP.
Voiding and sexual dysfunctions after pelvic fracture urethral injuries treated with either initial cystostomy and delayed urethroplasty or immediate primary urethral realignment.

OBJECTIVE The aim of this study is to evaluate the effects of the different immediate treatment modalities on the sexual and voiding functions in pelvic fracture urethral injuries. METHODS The records of 38 male patients with traumatic posterior urethral injuries were reviewed, 18 of whom were treated by initial suprapubic cystostomy and delayed repair (Group 1), and 20 by primary urethral realignment (Group 2). Types of pelvic fractures and urethral injuries were classified according to surgical and radiological findings. Long-term voiding functions were determined by the patient questionnaire, residual urine and uroflow. Sexual functions were also determined by the patient questionnaire and a penile duplex ultrasound study. RESULTS Mean follow-ups of Groups 1 and 2 were 37 and 39 months, respectively. Membranous urethral disruption extending to the urogenital diaphragm was the most frequent urethral injury (type 3), with incidences of 66.7% and 77.7%, respectively. There were no statistically significant differences in mean age, incidence of pelvic fracture types and urethral injury types between groups (p > 0.05). After the immediate treatments, 16.7% and 55% of the patients regained normal urination, and stricture developed in 83.3% and 45% of the patients, respectively. In 44.4% of the patients in Group 1 and 10% in Group 2, urethral strictures required open urethroplasty (p < 0.05). Erectile impotence before urethroplasty in 17.6% and 20%, anejaculation after urethroplasty in 17.6% and 15% and incontinence in 5.6% and 10% of the patients were found in Groups 1 and 2, respectively (p > 0.05). However, 88.8% and 90% of patients eventually achieved normal urination with complete continence. CONCLUSION Sexual and voiding dysfunction after pelvic fracture posterior urethral injury seem to be the result of the injury itself, not of the immediate treatment modalities. In urethral disruption injuries, primary urethral realignment seems more favourable than suprapubic cystostomy and delayed repair.
A comprehensive evaluation of the toxicology of experimental, non-filtered cigarettes manufactured with different circumferences

Abstract Context: Historical work indicates that cigarette circumference may affect the toxicological profile of experimental cigarettes. Objective: Studies were conducted to examine the effect of different cigarette circumferences on (1) selected mainstream smoke constituents including concentrations of tobacco specific nitrosamines (TSNA) in smoke and (2) mutagenicity and cytotoxicity of cigarette smoke condensate. Materials and methods: Analytical chemistry, Salmonella mutagenicity and cytotoxicity assays were used to evaluate the composition and biological activity of mainstream smoke from experimental, non-filtered cigarettes manufactured with four different circumferences (17.0–27.1 mm). Results: Most smoke constituents, including TSNA, decreased with decreasing cigarette circumference; however, amounts of hydrogen cyanide increased in a non-circumference dependent manner. Mutagenicity and cytotoxicity also decreased slightly with decreasing cigarette circumference. Conclusion: Cigarette circumference may have a minor role in the toxicological profile of experimental cigarettes, with a so-far-unidentified mechanism.
Screening of obstructive sleep apnea syndrome by heart rate variability analysis.

BACKGROUND Enhanced nocturnal heart rate variability (HRV) has been evoked in sleep-related breathing disorders. However, its capacity to detect obstructive sleep apnea syndrome (OSAS) has not been systematically determined. Thus, we evaluated the discriminant power of HRV parameters in a first group of patients (G1) and validated their discriminant capacity in a second group (G2). METHODS AND RESULTS In G1, 39 of 91 patients (42.8%) were identified as diseased by polysomnography, as were 24 of 52 patients (46%) in G2. Time-domain HRV variables (SD of NN intervals [SDNN], mean of the standard deviations of all NN intervals for all consecutive 5-minute segments of the recording [SDNN index], square root of the mean of the sum of the squares of differences between adjacent normal RR intervals [r-MSSD], and SD of the averages of NN intervals in all 5-minute segments of the recording [SDANN]) were calculated for daytime and nighttime periods, as well as the differences between daytime and nighttime values (Delta[D/N]). Correlations between HRV variables and OSAS status were analyzed in G1 by use of receiver-operating characteristic (ROC) curves and logistic regression analysis. By ROC curve analysis, 7 variables were significantly associated with OSAS. After adjustment for other variables through multiple logistic regression analysis, Delta[D/N]SDNN index and Delta[D/N] r-MSSD remained significant independent predictors of OSAS, with ORs of 8.22 (95% CI, 3.16 to 21.4) and 2.86 (95% CI, 1.21 to 6.75), respectively. The classification and regression tree methodology demonstrated a sensitivity reaching 89.7% (95% CI, 73.7 to 97.7) with Delta[D/N] SDNN index and a specificity of 98.1% (95% CI, 86.4 to 100) with Delta[D/N] SDNN using appropriate thresholds. These thresholds, applied to G2, yielded a sensitivity of 83% using Delta[D/N] SDNN index and a specificity of 96.5% using Delta[D/N] SDNN. CONCLUSIONS Time-domain HRV analysis may represent an accurate and inexpensive screening tool in clinically suspected OSAS patients and may help focus resources on those at the highest risk.
Unmanned Aeronautical Ad-hoc Networks: Enhancing the Reactive-Greedy-Reactive Protocol and Introducing a New Mobility Model

Unmanned Aeronautical Ad-hoc Networks (UAANETs) are infrastructure-less and self-organizing networks that are formed by small and medium sized Unmanned Aerial Vehicles (UAVs) that are deployed for a wide range of civilian and military applications. Having a reliable routing protocol for communication between the UAVs is critical. Our goal in this research is twofold. First, we enhance one of the existing routing protocols, the Reactive-Greedy-Reactive (RGR) protocol. In doing so, we propose the Optimized-RGR. Secondly, we propose the Enhanced Gauss-Markov (EGM) mobility model for UAANET simulations to replace the widely used, but unrealistic, Random Waypoint (RWP) mobility model. Simulations performed using the OPNET simulator show that Optimized-RGR outperforms RGR. There is a 5.3% increase in Packet Delivery Ratio at a negligible cost in latency. Furthermore, realistic mobility models, including EGM, show a lot of network partitioning. Therefore, this should be taken very seriously when developing a routing protocol for UAANETs.
A new method of magnetic resonance image reconstruction with short acquisition time and truncation artifact reduction

A method for the reconstruction of magnetic resonance images that allows for a substantial reduction of the quantity of measured data and, therefore, of the acquisition time is described. The truncation artifact is also reduced, improving the image quality. The method is based on techniques for getting superresolution in spectral analysis such as autoregressive modeling and Prony's method. Moreover, some new ideas about the autoregressive order selection are introduced. The method is compared to the standard one for reconstructing simulated, phantom, and medical magnetic resonance images. The numerical stability and the computational cost issues of the resulting algorithm are also addressed.
Genome-Wide Scan for Linkage to Type 1 Diabetes in 2,496 Multiplex Families From the Type 1 Diabetes Genetics Consortium

OBJECTIVE Type 1 diabetes arises from the actions of multiple genetic and environmental risk factors. Considerable success at identifying common genetic variants that contribute to type 1 diabetes risk has come from genetic association (primarily case-control) studies. However, such studies have limited power to detect genes containing multiple rare variants that contribute significantly to disease risk. RESEARCH DESIGN AND METHODS The Type 1 Diabetes Genetics Consortium (T1DGC) has assembled a collection of 2,496 multiplex type 1 diabetic families from nine geographical regions containing 2,658 affected sib-pairs (ASPs). We describe the results of a genome-wide scan for linkage to type 1 diabetes in the T1DGC family collection. RESULTS Significant evidence of linkage to type 1 diabetes was confirmed at the HLA region on chromosome 6p21.3 (logarithm of odds [LOD] = 213.2). There was further evidence of linkage to type 1 diabetes on 6q that could not be accounted for by the major linkage signal at the HLA class II loci on chromosome 6p21. Suggestive evidence of linkage (LOD ≥2.2) was observed near CTLA4 on chromosome 2q32.3 (LOD = 3.28) and near INS (LOD = 3.16) on chromosome 11p15.5. Some evidence for linkage was also detected at two regions on chromosome 19 (LOD = 2.84 and 2.54). CONCLUSIONS Five non–HLA chromosome regions showed some evidence of linkage to type 1 diabetes. A number of previously proposed type 1 diabetes susceptibility loci, based on smaller ASP numbers, showed limited or no evidence of linkage to disease. Low-frequency susceptibility variants or clusters of loci with common alleles could contribute to the linkage signals observed.
Toll‐like receptor‐7 ligand imiquimod induces type I interferon and antimicrobial peptides to ameliorate dextran sodium sulfate‐induced acute colitis

Background: The pathogenesis of inflammatory bowel disease (IBD) is associated with a dysregulated mucosal immune response. Certain stimulators of innate immunity (CpG DNA or GM‐CSF) are reported to be anti‐inflammatory in IBD. Toll‐like receptor‐7 (TLR7) is an important regulator of innate immunity and its activation plays a key role in induction of type I interferon (IFN). The present study tests the hypothesis that the TLR7 agonists Imiquimod has therapeutic efficacy in IBD. Methods: Acute colitis was induced in Balb/c mice by giving 5% dextran sodium sulfate (DSS) in drinking water for 7 days. Mice were treated with Imiquimod either orally or topically and its therapeutic effects on disease activity were examined. Isolated mouse CD11c+ dendritic cells and human intestinal epithelial cells (HT29, HCT116) were treated with Imiquimod (10 &mgr;g/mL) and their susceptibility to intracellular Salmonella typhimurium infection was assessed by gentamicin protection assay. Results: Oral administration of Imiquimod induced type I IFN expression in the gastrointestinal mucosa and ameliorated DSS‐induced acute colitis as assessed by clinical parameters, histology, and mRNA expression of proinflammatory cytokines. Topical administration of Imiquimod also ameliorated DSS colitis by inducing the expression of type I IFN in the colonic mucosa. However, no evidence for a systemic IFN response was observed. Imiquimod treatments to both CD11c+ and intestinal epithelial cells significantly increased expression of antimicrobial peptides (AMPs) and reduced survival of intracellular S. typhimurium. Conclusions: Imiquimod induces type I IFN and AMP to ameliorate DSS‐induced acute colitis and prevents Salmonella survival. Therefore, Imiquimod treatments provide a new therapeutic approach for IBD patients. (Inflamm Bowel Dis 2011;)
Maximization of Spreading Code Cardinality Using Transpose Function in Synchronous Optical CDMA

—This paper proposes a novel spreading code-set construction based on the prime code (PC) families and transpose function, referred to as 'transposed modified prime codes (T-MPC)', for the application in synchronous incoherent optical code-division multiple-access (OCDMA) networks. This code family increases the cardinality up to twice of existing PC families' size. T-MPC unlike conventional MPC, is not predictable and thus securer, yet the code structure is similar to MPC, its deployment will not require hardware modification. Due to the higher code utilization factor of T-MPC, greater number of users is accommodated under certain bit-error rate (BER) resulting in remarkable improvement in the networks' spectral efficiency (SE) and capacity. The T-MPC compatibility with low-weight energy-efficient MPC construction is also investigated. The BER and SE performances are analyzed and compared with existing code families. The results indicated that the T-MPC employment can improve up to 50% higher SE and network capacity.
Last Words: Amazon Mechanical Turk: Gold Mine or Coal Mine?

Recently heard at a tutorial in our field: “It cost me less than one hundred bucks to annotate this using Amazon Mechanical Turk! ” Assertions like this are increasingly common, but we believe they should not be stated so proudly; they ignore the ethical consequences of using MTurk (Amazon Mechanical Turk) as a source of labor. Manually annotating corpora or manually developing any other linguistic resource, such as a set of judgments about system outputs, represents such a high cost that many researchers are looking for alternative solutions to the standard approach. MTurk is becoming a popular one. However, as in any scientific endeavor involving humans, there is an unspoken ethical dimension involved in resource construction and system evaluation, and this is especially true of MTurk. We would like here to raise some questions about the use of MTurk. To do so, we will define precisely what MTurk is and what it is not, highlighting the issues raised by the system. We hope that this will point out opportunities for our community to deliberately value ethics above cost savings.
On the secrecy degress of freedom of the multi-antenna block fading wiretap channels

We consider the multi-antenna wiretap channel in which the transmitter wishes to send a confidential message to its receiver while keeping it secret to the eavesdropper. It has been known that the secrecy capacity of such a channel does not increase with signal-to-noise ratio when the transmitter has no channel state information (CSI) under mild conditions. Motivated by Jafar's robust interference alignment technique, we study the so-called staggered multi-antenna block-fading wiretap channel where the legitimate receiver and the eavesdropper have different temporal correlation structures. Assuming no CSI at transmitter, we characterize lower and upper bounds on the secrecy degrees of freedom (s.d.o.f.) of the channel at hand. Our results show that a positive s.d. o.f. can be ensured whenever two receivers experience different fading variation. Remarkably, very simple linear precoding schemes provide the optimal s.d. o.f. in some cases of interest.