Miracle-dz/UniFAR-FTUs huggingface dataset:
Tumour necrosis factor -308 and -238 promoter polymorphisms are predictors of a null virological response in the treatment of Brazilian hepatitis C patients

Certain host single nucleotide polymorphisms (SNPs) affect the likelihood of a sustained virological response (SVR) to treatment in subjects infected with hepatitis C virus (HCV). SNPs in the promoters of interleukin (IL)-10 (-1082 A/G, rs1800896), myxovirus resistance protein 1 (-123 C/A, rs17000900 and -88 G/T, rs2071430) and tumour necrosis factor (TNF) (-308 G/A, rs1800629 and -238 G/A, rs361525) genes and the outcome of PEGylated α-interferon plus ribavirin therapy were investigated. This analysis was performed in 114 Brazilian, HCV genotype 1-infected patients who had a SVR and in 85 non-responders and 64 relapsers. A significantly increased risk of having a null virological response was observed in patients carrying at least one A allele at positions -308 [odds ratios (OR) = 2.58, 95% confidence intervals (CI) = 1.44-4.63, p = 0.001] or -238 (OR = 7.33, 95% CI = 3.59-14.93, p < 0.001) in the TNF promoter. The risk of relapsing was also elevated (-308: OR = 2.87, 95% CI = 1.51-5.44, p = 0.001; -238: OR = 4.20, 95% CI = 1.93-9.10, p < 0.001). Multiple logistic regression of TNF diplotypes showed that patients with at least two copies of the A allele had an even higher risk of having a null virological response (OR = 16.43, 95% CI = 5.70-47.34, p < 0.001) or relapsing (OR = 6.71, 95% CI = 2.18-20.66, p = 0.001). No statistically significant association was found between the other SNPs under study and anti-HCV therapy response.
When no one is watching: evaluating the impact of body-worn cameras on use of force incidents

ABSTRACT Outcomes associated with police body-worn cameras (BWCs) and their influence on use of force is chiefly known from large-scale implementation studies and randomised controlled trials. While these studies provide valuable insight, there is concern that these studies are susceptible to the Hawthorne effect. Using an interrupted time series analysis, this study examines whether the implementation of BWCs had an effect on use of force incidents within a United States department that independently adopted BWCs and did not participate in a collaborative research trial. Results show that while there was a non-significant drop in use of force incidents at the month of BWC implementation, there was a steady, significant increase in use of force incidents for every month following implementation. The number of incidents reaches pre-BWC implementation frequencies after three years. These findings indicate that BWCs may influence police behaviour immediately following implementation, though this influence weakens over time as BWCs become normalised with daily police use.
Prevalence and Characterization of Murine Leukemia Virus Contamination in Human Cell Lines

Contaminations of cell cultures with microbiological organisms are well documented and can be managed in cell culture laboratories applying reliable detection, elimination and prevention strategies. However, the presence of viral contaminations in cell cultures is still a matter of debate and cannot be determined with general detection methods. In the present study we screened 577 human cell lines for the presence of murine leukemia viruses (MLV). Nineteen cell lines were found to be contaminated with MLV, including 22RV1 which is contaminated with the xenotropic murine leukemia virus-related virus variant of MLV. Of these, 17 cell lines were shown to produce active retroviruses determined by product enhanced reverse transcriptase PCR assay for reverse transcriptase activity. The contaminated cell lines derive from various solid tumor types as well as from leukemia and lymphoma types. A contamination of primary human cells from healthy volunteers could not be substantiated. Sequence analyses of 17 MLV PCR products and five complete MLV genomes of different infected cell lines revealed at least three groups of related MLV genotypes. The viruses harvested from the supernatants of infected cell cultures were infectious to uninfected cell cultures. In the course of the study we found that contamination of human genomic DNA preparations with murine DNA can lead to false-positive results. Presumably, xenotransplantations of the human tumor cells into immune-deficient mice to determine the tumorigenicity of the cells are mainly responsible for the MLV contaminations. Furthermore, the use of murine feeder layer cells during the establishment of human cell lines and a cross-contamination with MLV from infected cultures might be sources of infection. A screening of cell cultures for MLV contamination is recommended given a contamination rate of 3.3%.
Global finite-time convergence of TCP Vegas without feedback information delay

We prove that TCP Vegas globally converges to its equilibrium point in finite time assuming no feedback information delay. We analyze a continuous-time TCP Vegas model with discontinuity and high nonlinearity. Using the upper right-hand derivative and applying the comparison lemma, we cope with the discontinuous signum function in the TCP Vegas model; using a change of state variables, we deal with the high nonlinearity. Although we ignore feedback information delay in analyzing the model of TCP Vegas, the simulation results illustrate that TCP Vegas in the presence of feedback information delay shows very similar dynamic trends to TCP Vegas without feedback information delay. Consequently, dynamic properties of TCP Vegas without feedback information delay can be used to estimate those of TCP Vegas in the presence of feedback information delay.
The Effect of Central Bank Liquidity Injections on Bank Credit Supply

We study the effectiveness of central bank liquidity injections in restoring bank credit supply following a wholesale funding dry-up. We combine borrower-level data from the Italian credit registry with bank security-level holdings and analyze the transmission of the European Central Bank three-year Long Term Refinancing Operation. Exploiting a regulatory change that expands eligible collateral, we show that banks more affected by the dry-up use this facility to restore their credit supply, while less affected banks use it to increase their holdings of high-yield government bonds. Unable to switch from affected banks during the dry-up, firms benefit from the intervention.
An Exploration of Factors Contributing to Students’ Unwillingness to Communicate in a Foreign Language across Indonesian Secondary Schools

This quantitative survey attempts to explore factors that contribute to English as a foreign language (EFL) students’ unwillingness to communicate across Indonesian secondary schools. To this end, an online questionnaire was distributed to the students via school Facebook pages and Twitter. A total of 158 students volunteered to participate, of which 122 were female, and 36 were male. The qualitative data were analyzed statistically using factor analysis, ANOVA, correlation, and regression. The study findings showed that there was significant correlation between the unwillingness to communicate scale (UCS) and its two factors, i.e. UCS1 and UCS2 were significant (r-UCS1 = .867, p < .01, r-UCS2 = .772, p < .01). These results indicate that students’ unwillingness to communicate was highly influenced by whether or not students decided to stay away from the conversation or on the extent to which students valued the communication itself and vice versa. In addition, the regression analysis of the two variables, students’ risk-taking to communicate and engagement in communication, revealed that none of the variables were perceived as predictors of the students’ unwillingness to communicate [language class risk (LCR), β = -. 198, t = -2.64, p = . 009; and language class sociability (LCS), β = -. 352, t = -4.69, p = . 000].
The early stage of a cosmic collision? XMM-Newton unveils two obscured AGN in the galaxy pair ESO509-IG066

We report the XMM-Newton discovery of a X-ray bright AGN pair in the interacting galaxy system ESO509-IG066. Both galaxies host an X-ray luminous (LX ∼ 10 43 erg s −1 ) obscured nucleus with column densities NH � 7 × 10 22 cm −2 and NH � 5 × 10 21 cm −2 . The optical morphology is only mildly disturbed, suggesting a merging system in the early stage of its evolution. Still, the pair is probably gravitationally bound, and might eventually evolve into a compact, fully gas embedded systems such as NGC 6240 (Komossa et al. 2003).
“It’s a Concrete Ceiling; It’s Not Even Glass”: Understanding Tenets of Organizational Culture That Supports the Progression of Women as Coaches and Coach Developers

The purpose of this study was to explore what particular areas of organizational cultures facilitate the development and progression of women as football coaches and coach developers. The English Football Association provided the context for the research. Previous statistics demonstrate that recruitment, retention, and progression of women in English football coaching and tutoring are lower and slower than their male counterparts. In-depth interviews were completed with 26 women coaches and coach developers during November 2015 and February 2016 to understand their personal experiences as linked to the structure and culture of their sporting governing body, and analyzed using Schein’s theory of organizational culture. Three key tenets of organizational culture were found to be most influential on the career development of the participants: journeys and crossroads (the establishment of a learning culture), inclusive leadership, and vertical and horizontal relationships. The research demonstrates the need to identify disparities between espoused values and assumptions to enact cultural change toward supporting more women to be valued, included, and progressed in the sporting workplace.
The Modern Day Baby Book: Enacting Good Mothering and Stewarding Privacy on Facebook

The practice of sharing family photographs is as old as the camera itself. Many mothers now share baby photos online, yet little is known about what kinds of baby photos they share and their motivations for doing so. Drawing on semi-structured interviews with 22 new mothers, we find that they share cute, funny, milestone, and family and friend photos but refrain from sharing crying and naked photos. While some mothers harbor concerns about controlling information, oversharing, and digital footprints, the benefits of receiving validation outweighs their concerns. Sharing baby photos on Facebook helps new mothers enact and receive validation of "good mothering. " However, mothers are charged with the responsibility of stewarding their children's privacy and identities online. We introduce the concept of privacy stewardship to describe the responsibility parents take on when deciding what is appropriate to share about their children online and ensuring that family and friends respect and maintain the integrity of those rules. As a result, mothers must exchange benefits of sharing baby photos with risks of creating digital footprints for their child.
Sexual harassment expanded: An examination of the relationships among sexual harassment, sex discrimination, and aggression in the workplace

ABSTRACT We hypothesized that sexual harassment is part of a broader behavioral family including aggression and discrimination. We examined whether the relationships between these types of mistreatment can be represented well by a general factor that relates to other workplace variables. Evidence from military datasets showed that sexual harassment, sex discrimination, and workplace aggression can be conceptualized as a more general factor that functioned well in an integrated model of sexual harassment and was experienced differently by men and women. Thus, there is utility in examining these types of mistreatment both together and independently, both for research and prevention purposes.
Gravitational duality and rotating solutions

We study how gravitational duality acts on rotating solutions, using the Kerr-NUT black hole as an example. After properly reconsidering how to take into account both electric (i.e. masslike) and magnetic (i.e. NUT-like) sources in the equations of general relativity, we propose a set of definitions for the dual Lorentz charges. We then show that the Kerr-NUT solution has nontrivial such charges. Further, we clarify in which respect Kerr's source can be seen as a mass M with a dipole of NUT charges.
Population ecology of the invasive kelp Undaria pinnatifida in California: environmental and biological controls on demography

We combined field monitoring and laboratory experiments to examine the population ecology of both the microscopic and macroscopic stages of a new invasion of Undaria pinnatifida in California. Over the course of 1 yr, we observed 2 distinct recruitment pulses of individuals in the Santa Barbara harbor; the appearance of these pulses was strongly correlated with a 4°C drop in ocean temperature approximately 2 mo prior to recruitment. Cultures of zoospores and successive microscopic stages revealed thermal tolerances consistent with field recruitment data; individuals grown at 13°C had significantly higher survivorship than individuals grown at higher temperatures (harbor temperatures annually ranged from 12 to 21°C). The 2 cohorts also differed greatly in individual size, growth rate, and survival to maturity. Grazing by herbivores, predominately the native kelp crab Pugettia producta, effectively prevented nearly all individuals in the second cohort from reaching reproductive maturity. Grazer control was effective despite far higher rates of recruitment during the second recruitment pulse. Our results highlight the potential for extreme variability in U. pinnatifida demography mediated by local oceanographic and biotic factors. Understanding controls on U. pinnatifida demography helps to explain variation in the spread and impact of this invader worldwide, and allows better prediction of when and where U. pinnatifida may continue its invasion along the west coast of North America.
“Going natural”: Black women’s identity project shifts in hair care practices

ABSTRACT Hair care, a seemingly mundane consumption practice, is packed with sociocultural meanings and constitutes an important realm of identity work for consumers. Drawing upon existing literature on consumer identity projects, this paper investigates the experiences of urban, Black women in Kenya as they disengage from the normative practice of altering their natural hair texture using chemical straighteners (a practice that conforms to Eurocentric beauty ideals of straight, flowing hair), and adopt the non-normative hair care practice of “going natural,” in which they embrace their natural hair texture and hairstyles. This paper traces the historical, sociocultural, and political events that underpin the normative ideology associated with the identity marker of natural Black hair, and how this ideology influences the women’s “going natural” experience. Findings reveal tensions that emerge in the women’s identity project disengagement and reconstruction process, and how the women navigate their position as they reimagine their embodied identity quest.
Realism for scientific ontologies

Science aims to develop an accurate understanding of reality through a variety of rigorously empirical and formal methods. Ontologies are used to formalize the meaning of terms within a domain of discourse. The Basic Formal Ontology (BFO) is an ontology of particular importance in the biomedical domains, where it provides the top-level for numerous ontologies, including those admitted as part of the OBO Foundry collection. The BFO requires that all classes in an ontology are actually instantiated in reality. Despite the fact that it is hard to show whether entities of some kind exist or do not exist in reality (especially for unobservable entities like elementary particles), this criterion fails to satisfy the need of scientists to communicate their findings and theories unambiguously. We discuss the problems that arise due to the BFO's realism criterion and suggest viable alternatives.
Exploring the views and perceptions of adopted young people concerning their education and social development: an interpretative phenomenological analysis

ABSTRACT A large percentage of young people who have been adopted will have experienced early childhood trauma and neglect that can impact on their social and emotional development, and engagement with learning. Although much research has been carried out concerning adoption, the views and perspectives of adopted young people are often missing. This small-scale qualitative study aimed to explore the experiences of four adopted young people, aged between 10 and 16 years, who were interviewed using semi-structured interviews. Transcripts were analysed using interpretative phenomenological analysis. While five themes emerged from the interviews with the young people; “identity and self”, “relationships”, “school”, “attachment” and “adoptive status”, their individual accounts were distinctive and subjective, as a result of their pre-and post-adoption experiences. This study considers the implications of the findings for educational psychology practice.
IS THE DODO BIRD A JEDI OR A SITH? A COMMENTARY OF EFFICACY ACROSS THERAPEUTIC MODALITIES

Abstract In this paper we discuss the issue of the Dodo verdict, i.e the empirically supported notion that different psychotherapeutic modalities have same outcomes. Firstly, we present the historical backround of this notion, and link it with the current issues in psychotherapy. Conversely, we present the pertinent literature which focuses on the similarities and differences in outcomes across modalities as well as elucidate recognised effective instances in psychotherapy. Additionaly, we discuss the trends in efficacy research and posit questions about the nature of the theory and practice of psychotherapy. We also provide a critique and offer different perspectives on the importance and meaning of the Dodo conjecture, concerning both therapeutic and extra – therapeutic consequences and corellates. Keywords : psychotherapy, efficacy, Dodo verdict
Registered Reports: Genre Evolution and the Research Article

The research article is a staple genre in the economy of scientific research, and although research articles have received considerable treatment in genre scholarship, little attention has been given to the important development of Registered Reports. Registered Reports are an emerging, hybrid genre that proceeds through a two-stage model of peer review. This article charts the emergence of Registered Reports and explores how this new form intervenes in the evolution of the research article genre by replacing the central topoi of novelty with methodological rigor. Specifically, I investigate this discursive and publishing phenomenon by describing current conversations about challenges in replicating research studies, the rhetorical exigence those conversations create, and how Registered Reports respond to this exigence. Then, to better understand this emerging form, I present an empirical study of the genre itself by closely examining four articles published under the Registered Report model from the journal Royal Society Open Science and then investigating the genre hybridity by examining 32 protocols (Stage 1 Registered Reports) and 77 completed (Stage 2 Registered Reports) from a range of journals in the life and psychological sciences. Findings from this study suggest Registered Reports mark a notable intervention in the research article genre for life and psychological sciences, centering the reporting of science in serious methodological debates.
Organization of cytokeratin bundles by desmosomes in rat mammary cells

In a rat mammary epithelial cell line, LA-7, cytokeratin bundles recognized in immunofluorescence by a monoclonal antibody (24B42) disappear after trypsinization of cultures and are gradually reformed after replating. We have followed the time course of cytokeratin filament reappearance by growing cells in low calcium medium (0.1 mM) which prevents desmosome formation, and then shifting to high calcium (1.8 mM) to start the process. By fixing the cells at various intervals and staining them in immunofluorescence for 24B42 cytokeratin and for desmosomal proteins, we found that cell to cell contact and desmosome formation are prerequisites for keratin filament formation in these cells. EGTA treatment, by disassembling desmosomes, causes the cytokeratin filaments to disappear and the 24B42 protein to pass into a soluble form in this cell line, as ascertained by 100,000 g fractionation and immunoenzymatic assay. Cycloheximide treatment also causes cytokeratin filaments to disappear, indicating that protein synthesis is needed for normal filament maintenance. In another related cell line (106A-10a) and in HeLa cells, trypsinization and EGTA exposure do not cause a complete loss of 24B42 immunofluorescence, although distinct filaments disappear, indicating the presence in these cells of different organizing centers, besides desmosomes, for cytokeratin bundle formation. LA7 cells therefore seem to have a cytokeratin system strictly dependent on the presence of desmosomes, which act as an organizing center for filament assembly. 106A-10a cells (also rich in desmosomes) and HeLa cells (showing instead a reduced number of desmosomes) have a cytokeratin system partially or totally independent from that of desmosomes, with different organizing centers.
Double Field Theory

The zero modes of closed strings on a torus — the torus coordinates plus dual coordinates conjugate to winding number — parameterize a doubled torus. In closed string field theory, the string field depends on all zero-modes and so can be expanded to give an infinite set of fields on the doubled torus. We use string field theory to construct a theory of massless fields on the doubled torus. Key to the consistency is a constraint on fields and gauge parameters that arises from the L0−0 = 0 condition in closed string theory. The symmetry of this double field theory includes usual and `dual diffeomorphisms', together with a T-duality acting on fields that have explicit dependence on the torus coordinates and the dual coordinates. We find that, along with gravity, a Kalb-Ramond field and a dilaton must be added to support both usual and dual diffeomorphisms. We construct a fully consistent and gauge invariant action on the doubled torus to cubic order in the fields. We discuss the challenges involved in the construction of the full nonlinear theory. We emphasize that the doubled geometry is physical and the dual dimensions should not be viewed as an auxiliary structure or a gauge artifact.