Miracle-dz/UniFAR-FTUs huggingface dataset:
Transcriptomic Insight in the Control of Legume Root Secondary Infection by the Sinorhizobium meliloti Transcriptional Regulator Clr

The cAMP-dependent transcriptional regulator Clr of Sinorhizobium meliloti regulates the overall number of infection events on Medicago roots by a so-far unknown mechanism requiring smc02178, a Clr-target gene of unknown function. In order to shed light on the mode of action of Clr on infection and potentially reveal additional biological functions for Clr, we inventoried genomic Clr target genes by transcriptome profiling. We have found that Clr positively controls the synthesis of cAMP-dependent succinoglycan as well as the expression of genes involved in the synthesis of a so-far unknown polysaccharide compound. In addition, Clr activated expression of 24 genes of unknown function in addition to smc02178. Genes negatively controlled by Clr were mainly involved in swimming motility and chemotaxis. Functional characterization of two novel Clr-activated genes of unknown function, smb20495 and smc02177, showed that their expression was activated by the same plant signal as smc02178 ex planta. In planta, however, symbiotic expression of smc02177 proved independent of clr. Both smc02177 and smb20495 genes were strictly required for the control of secondary infection on M. sativa. None of the three smc02177, smc02178 and smb20495 genes were needed for plant signal perception. Altogether this work provides a refined view of the cAMP-dependent Clr regulon of S. meliloti. We specifically discuss the possible roles of smc02177, smc02178, smb20495 genes and other Clr-controlled genes in the control of secondary infection of Medicago roots.
Communicating with the non-dominant hemisphere: Implications for neurological rehabilitation☆

Aphasic syndromes usually result from injuries to the dominant hemisphere of the brain. Despite the fact that localization of language functions shows little interindividual variability, several brain areas are simultaneously activated when language tasks are undertaken. Mechanisms of language recovery after brain injury to the dominant hemisphere seem to be relatively stereotyped, including activations of perilesional areas in the acute phase and of homologues of language areas in the non-dominant hemisphere in the subacute phase, later returning to dominant hemisphere activation in the chronic phase. Plasticity mechanisms reopen the critical period of language development, more specifically in what leads to disinhibition of the non-dominant hemisphere when brain lesions affect the dominant hemisphere. The non-dominant hemisphere plays an important role during recovery from aphasia, but currently available rehabilitation therapies have shown limited results for efficient language improvement. Large-scale randomized controlled trials that evaluate well-defined interventions in patients with aphasia are needed for stimulation of neuroplasticity mechanisms that enhance the role of the non-dominant hemisphere for language recovery. Ineffective treatment approaches should be replaced by more promising ones and the latter should be evaluated for proper application. The data generated by such studies could substantiate evidence-based rehabilitation strategies for patients with aphasia.
Region-Specific Reduction in Entorhinal Gamma Oscillations and Parvalbumin-Immunoreactive Neurons in Animal Models of Psychiatric Illness

Psychiatric illnesses, particularly schizophrenia, are associated with disrupted markers for interneuronal function and interneuron-mediated brain rhythms such as gamma frequency oscillations. Here we investigate a possible link between these two observations in the entorhinal cortex and hippocampus by using a genetic and an acute model of psychiatric illness. Lysophosphatidic acid 1 receptor-deficient (LPA1-deficient) mice show psychomotor-gating deficits and neurochemical changes resembling those seen in postmortem schizophrenia studies. Similar deficits are seen acutely with antagonism of the NMDA subtype of glutamate receptor. Neither model induced any change in power or frequency of gamma rhythms generated by kainate in hippocampal slices. In contrast, a dramatic decrease in the power of gamma oscillations was seen in superficial, but not deep, medial entorhinal cortex layers in both models. Immunolabeling for GABA, parvalbumin, and calretinin in medial entorhinal cortex from LPA1-deficient mice showed an ∼40% reduction in total GABA- and parvalbumin-containing neurons, but no change in the number of calretinin-positive neurons. This deficit was specific for layer II (LII). No change in the number of neurons positive for these markers was seen in the hippocampus. Acute NMDA receptor blockade, which selectively reduces synaptic drive to LII entorhinal interneurons, also disrupted gamma rhythms in a similar manner in superficial entorhinal cortex, but not in hippocampus. These data demonstrate an area-specific deficit in gamma rhythmogenesis in animal models of psychiatric illness and suggest that loss, or reduction in function, of interneurons having a large NMDA receptor expression may underlie the network dysfunction that is seen.
Object exchange across heterogeneous information sources

We address the problem of providing integrated access to diverse and dynamic information sources. We explain how this problem differs from the traditional database integration problem and we focus on one aspect of the information integration problem, namely information exchange. We define an object-based information exchange model and a corresponding query language that we believe are well suited for integration of diverse information sources. We describe how, the model and language have been used to integrate heterogeneous bibliographic information sources. We also describe two general-purpose libraries we have implemented for object exchange between clients and servers. <<ETX>>
CAPITAL STRUCTURE MODEL (Empirical Study on IDX 2020-2022)

The food and beverage industry are constantly evolving and shaped by consumer preferences, making it crucial for companies to consider the various factors that impact their revenue streams. Analyzing the structure of a company's assets and the rate of its sales growth are crucial factors to consider, as they greatly influence the financial management practices of the company. Asset structure means what a company owns, and sales growth shows if the company is making more or less money. The aim of this research is to examine how the capital structure is influenced by asset structure, sales growth, and the role of profitability in mediating this connection. The study utilized a quantitative research methodology. The research population consisted of companies in the food and beverage subsector on the IDX from 2020 to 2022. A total of 23 companies were selected as the sample over a 3-year period, resulting in 69 data points using purposive sampling technique. The data analysis involved multiple linear regression analysis with the assistance of SPSS version 17. The study's results show that both the composition of assets and the growth in sales have a favorable and noteworthy influence on the structure of capital. Additionally, profitability plays a role in connecting the asset structure with the capital structure, as well as linking sales growth with the capital structure.
A low voltage CMOS bandgap reference without using an opamp

A simple low voltage CMOS bandgap voltage reference that does not require an opamp is proposed. The major advantage of this design is in its low current consumption. Most of the total current consumption in the circuit is used for generating the output voltage. To improve the line regulation as well as the robustness of the design against process variations, a technique for modifying the feedback loop in the circuit was also proposed. Such modification does not require additional die area and power consumption. The proposed techniques were demonstrated with two low voltage bandgap reference designs using a conventional 0. 18µm CMOS process. The reference that was designed with the proposed modified feedback loop achieved a temperature coefficient of ≪ 10ppm/°C and a line regulation of ≪ 0.4mV/V with a current consumption of ∼5µA from a 1V supply.
More about low-dose rituximab and plasma exchange as front-line therapy for patients with thrombotic thrombocytopenic purpura

Introduction: Thrombotic thrombocytopenic purpura (TTP) is characterized by a reduction in the von Willebrand cleavage protein ADAMTS-13, mainly as a consequence of autoimmunity. Plasma exchange (PEx) is standard, achieving complete remission (CR) in 77–83% of cases, but rates are variable depending on ADAMTS-13 activity and relapse is frequent in patients with <10%. Thus, an effective front-line immunosuppressive treatment is needed. Materials and methods: We administered PEx daily until CR and rituximab 100 mg/dose/week for 4 consecutive weeks to 10 patients with a first TTP episode and 1 relapsed patient (8 females (72%) and 3 males (28%)). Median age was 34 years (15–46) and laboratory parameters at diagnosis were as follows: platelets 11 × 109/l (range 7–27.4 × 109/l), lactate dehydrogenase 1822 U/l (range 705–8220 U/l, normal 70–180 U/l), and haemoglobin 6 g/dl (range 4.2–11.8 g/dl). ADAMTS-13 activity was determined in eight patients and was <10% in all. ADAMTS-13 autoantibody titre was determined in seven patients and was >15 units/ml in all (ref: negative <12, undetermined 12–15, positive >15 units/ml); Shiga toxin was negative in all patients. The median number of PEx until CR was 7 (range 4–12); prednisone 1 mg/kg was administered to six patients. Results: The median follow-up was 22 months (range 4–49) and the estimated 2-year relapse-free survival was 89%; one HIV+ patient relapsed at 8 months follow-up. No complications related to PEx or rituximab were reported. Conclusions: Our study suggests that low-dose rituximab and PEx are effective as front-line treatment for acute TTP; however, a prospective trial is needed to demonstrate whether low-dose rituximab is as effective as the conventional dose.
The importance of being gravid: egg load and contest outcome in a parasitoid wasp

Owners have often been found to have an advantage in animal contests. One explanation of this is that the resource under dispute is of greater value to the owner than to the intruder (nonowner). Such 'resource value asymmetries' may be caused by intrinsic factors, such as the physiological state of the contestants. Females of the bethylid wasp Goniozus nephantidis fight for possession of paralysed hosts. A recent study found that larger females tend to win but owner status also confers an advantage. We tested the hypothesis that ownership advantage is linked to differences in egg load (the number of unlaid ripe eggs) between contestant females. Egg loads were highly variable and positively influenced by age, nutrition, body size and host ownership. Owners almost always won owner-intruder contests. The outcomes of owner-owner contests (in which size and status asymmetries were absent) were strongly influenced by differences in egg load. Copyright 2000 The Association for the Study of Animal Behaviour.
On hierarchical routing in wireless sensor networks

Hierarchical routing is a promising approach for point-to-point routing with very small routing state. While there are many theoretical analyses and high-level simulations demonstrating its benefits, there has been little work to evaluate it in a realistic wireless sensor network setting. Based on numerous proposed hierarchical routing infrastructures, we develop a framework that captures the common characteristics of the infrastructures and identifies design points where the infrastructures differ. We then evaluate the implementation of the framework in TOSSIM and on a 60-node testbed. We demonstrate that from the practical perspective hierarchical routing is also an appealing routing approach for sensor networks. Despite only logarithmic routing state, it can offer low routing stretch: the average of ∼1.25 and the 99-th percentile of 2. Moreover, a hierarchical routing infrastructure can be autonomously bootstrapped and maintained by the nodes. By exploring the design points within our framework, the hierarchy maintenance protocol can optimize different metrics, such as the latency of bootstrapping and repairing the hierarchy after failures or the traffic volume, depending on the application requirements. Finally, we also identify a number of practical issues which we believe the applications employing hierarchical routing should be aware of.
Distributed video streaming using complete complementary sequences

In many distributed video streaming applications multiple terminals stream correlated video data to a central station to be processed. The fact that those terminals may be placed within a short range of each other in a time-varying environment, results in a high level of interference, multipath fading and noise effects. One classical solution to reduce those effects is to employ the well-known spread spectrum technique; however, this leads to a substantial increase in the required bandwidth and usually makes the system not acceptable for real-time wireless video communications. In this paper we provide a novel spreading scheme that reduces the required bandwidth by exploiting correlation among different terminal observations of a video source without performance penalty. Results obtained show reduction in a terminal transmission rate of approximately 1 Mbit/sec per terminal for the same reconstructed video quality.
Girl child and social change.

This article discusses the state of social change and the disparity between India's Constitutional aims and actual practice in addressing gender inequality and the special risks of female children in India. The second part of this article summarizes Constitutional articles and laws relating to protection of women and a girl child. Before birth, a female child is at risk of fetal death. A woman is at risk of poorly performed abortions and maternal mortality. After birth, a girl child is at risk of child care of younger siblings, housework, lack of education, wage work for the household, sexual abuse, vulnerability at work or school or on the street, murder by her parents, abuse, malnutrition, and desertion. The SAARC summit declared 1990 the Year of the Girl Child. UN conventions and a world summit focused on the Rights of the Child. A child has a right to freedom from exploitation, neglect and abuse, and access to food, health care, and education. Articles 14, 15, and 16 of India's Constitution guarantee protection from discrimination on grounds of religion, race, caste, sex, or place of birth and equality of opportunity in public employment. Article 23 prohibits trafficking in humans and forced labor. Article 24 prohibits child labor under the age of 14 years. Article 39 assures an adequate means of livelihood, equal pay, and protection from child abuse and economic pressure to work in jobs unsuitable to a child's age and strength. Article 45 provides for free and compulsory education up to 14 years of age. Article 51 prohibits derogatory practices against women. Article 325 and 326 prohibits sex discrimination. Other laws pertain to dowry, marriage age, prostitution, abortion, juvenile justice, kidnapping, obscenity, procurement of a minor, sexual offenses, divorce and child support, child care, maternity benefits, and cruelty by a husband or relatives. The girl child in India continues to live in perpetual threat, both physiological and psychological.
Beyond Availability: Towards a Deeper Understanding of Machine Failure Characteristics in Large Distributed Systems

Although many previous research efforts have investigated machine failure characteristics in distributed systems, availability research has reached a point where properties beyond these initial findings become important. In this paper, we analyze traces from three large distributed systems to answer several subtle questions regarding machine failure characteristics. Based on our findings, we derive a set of fundamental principles for designing highly available distributed systems. Using several case studies, we further show that our design principles can significantly influence the availability design choices in existing systems.
WORK COMPLETED Boussinesq models for directionally spread breaking and nonbreaking waves ( Herbers

Steve Elgar Woods Hole Oceanographic Institution, MS#11 Woods Hole, MA 02543 phone: (508) 289-3614 fax: (508) 457-2194 email: elgar@whoi.edu Grant numbers: N00014-00-1-001, N00014-00-1-0018 R.T. Guza Scripps Institution of Oceanography La Jolla, CA 92093-0209 phone: (858) 534-0585 fax: (858) 534-0300 email: rguza@ucsd.edu Grant numbers: N00014-95-1-0085, N00014-00-1-0414, N00014-98-1-0473 http://science.whoi.edu/PVLAB/index.html
TwiSty: A Multilingual Twitter Stylometry Corpus for Gender and Personality Profiling

Personality profiling is the task of detecting personality traits of authors based on writing style. Several personality typologies exist, however, the Briggs-Myer Type Indicator (MBTI) is particularly popular in the non-scientific community, and many people use it to analyse their own personality and talk about the results online. Therefore, large amounts of self-assessed data on MBTI are readily available on social-media platforms such as Twitter. We present a novel corpus of tweets annotated with the MBTI personality type and gender of their author for six Western European languages (Dutch, German, French, Italian, Portuguese and Spanish). We outline the corpus creation and annotation, show statistics of the obtained data distributions and present first baselines on Myers-Briggs personality profiling and gender prediction for all six languages.
Image completion with structure propagation

In this paper, we introduce a novel approach to image completion, which we call structure propagation. In our system, the user manually specifies important missing structure information by extending a few curves or line segments from the known to the unknown regions. Our approach synthesizes image patches along these user-specified curves in the unknown region using patches selected around the curves in the known region. Structure propagation is formulated as a global optimization problem by enforcing structure and consistency constraints. If only a single curve is specified, structure propagation is solved using Dynamic Programming. When multiple intersecting curves are specified, we adopt the Belief Propagation algorithm to find the optimal patches. After completing structure propagation, we fill in the remaining unknown regions using patch-based texture synthesis. We show that our approach works well on a number of examples that are challenging to state-of-the-art techniques.
Component age estimates for the Hell Gap Paleoindian site and methods for chronological modeling of stratified open sites

Abstract The Hell Gap National Historic Landmark, located on the northwestern plains of Wyoming, is one of the most important Paleoindian archaeological sites in North America because it contains a stratified sequence of occupations spanning nearly the entirety of the Paleoindian period. Although Hell Gap is central to archaeological knowledge concerning North American Paleoindian chronology, consistently assigning component ages has been problematic due to conflicting radiocarbon determinations from individual strata, stratigraphic age reversals in age-depth relationships, and other issues related to the stratified open campsite. Toward resolving the Hell Gap chronology, we devised a procedure for correcting age-depth relationships for incorporation in chronostratigraphic models and then used the Bayesian age-depth modeling qprocedures in Bchron to estimate the ages of 11 stratified components present at Hell Gap Locality 1. We present these age estimates and discuss their significance to Paleoindian chronology. Notable aspects of our chronology include a revised age estimate for the Goshen complex, the identification of three Folsom components spanning the entirety of the Folsom temporal range, and relatively young age estimates for the Late Paleoindian Frederick/Lusk component(s) at Locality 1. More broadly, our study demonstrates a procedure for creating chronometric models of stratigraphically complicated open stratified sites of any type.
Functions of corazonin and histamine in light entrainment of the circadian pacemaker in the Madeira cockroach, Rhyparobia maderae

The circadian pacemaker of the Madeira cockroach, Rhyparobia (Leucophaea) maderae, is located in the accessory medulla (AME). Ipsi‐ and contralateral histaminergic compound eyes are required for photic entrainment. Light pulses delay locomotor activity rhythm during the early night and advance it during the late night. Thus, different neuronal pathways might relay either light‐dependent delays or advances to the clock. Injections of neuroactive substances combined with running‐wheel assays suggested that GABA, pigment‐dispersing factor, myoinhibitory peptides (MIPs), and orcokinins (ORCs) were part of both entrainment pathways, whereas allatotropin (AT) only delayed locomotor rhythms at the early night. To characterize photic entrainment further, histamine and corazonin were injected. Histamine injections resulted in light‐like phase delays and advances, indicating that the neurotransmitter of the compound eyes participates in both entrainment pathways. Because injections of corazonin only advanced during the late subjective night, it was hypothesized that corazonin is only part of the advance pathway. Multiple‐label immunocytochemistry in combination with neurobiotin backfills demonstrated that a single cell expressed corazonin in the optic lobes that belonged to the group of medial AME interneurons. It colocalized GABA and MIP but not AT or ORC immunoreactivity. Corazonin‐immunoreactive (‐ir) terminals overlapped with projections of putatively light‐sensitive interneurons from the ipsi‐ and contralateral compound eye. Thus, we hypothesize that the corazonin‐ir medial neuron integrates ipsi‐ and contralateral light information as part of the phase‐advancing light entrainment pathway to the circadian clock. J. Comp. Neurol. 525:1250–1272, 2017. © 2016 Wiley Periodicals, Inc.
An Expanded Taxonomy of Semiotic Classes for Text Normalization

We describe an expanded taxonomy of semiotic classes for text normalization, building upon the work in [1]. We add a large number of categories of non-standard words (NSWs) that we believe a robust real-world text normalization system will have to be able to process. Our new categories are based upon empirical findings encountered while building text normalization systems across many languages, for both speech recognition and speech synthesis purposes. We believe our new taxonomy is useful both for ensuring high coverage when writing manual grammars, as well as for eliciting training data to build machine learning-based text normalization systems.