Miracle-dz/UniFAR-FTUs huggingface dataset:
Teachers as Intercultural Learners: Negotiating German–American Telecollaboration along the Institutional Fault Line

This article examines how social, cultural, and institutional affordances and constraints in a telecollaborative foreign language learning partnership shape the agency of online teachers. In particular, it details how various aspects of schools and schooling impact the negotiation, execution, and management of a German–American virtual course from the perspectives of the teachers. These aspects include: the misalignment of academic calendars, local patterns of socialization into the teaching profession, institution–specific classroom scripts, systems of learning assessment, student workloads, and the physical layouts of local institutions and social forms of classroom collaboration. The article presents a self–reflective case study of our 10–month electronic negotiation, execution, and management of a German–American telecollaborative partnership within the constructivist paradigm of social realism. Using Agar's (1994) notion of the linguistic rich point and examining patterns of communication, specific lexical items, and grammatical structures, the study uncovers how the culturally varying nature of schools and schooling is linguistically encoded in the texts of electronic correspondence.
Different but the Same: Doctoral Students' Experience of Multiprofessional Education

Generic Professional Doctorate programmes provide students with the opportunity to study in multiprofessional cohorts. Although the professional doctorate student experience has been examined, the value of engaging in multiprofessional doctoral education has not been explored. The study aimed to explore the personal meanings that doctoral students ascribe to the value of studying within a multiprofessional context. A qualitative approach was employed. Data were collected through focus group discussions and individual interviews. A thematic analysis was conducted on the data. 23 doctoral students over four years of the programme participated in the study. Different but the same was a major theme that emerged from the data. The multiprofessional context and the 'difference' between the students offered identifiable enhancements to the academic process which were captured in three subthemes; 1) finding new worlds 2) getting clear and being clear and 3) travelling alone together. The study findings suggest that the multiprofessional context, mediated through a pedagogical approach of the contact hypothesis, enhanced the quality of the educational experience and outcomes.
Performance of downlink comp in LTE under practical constraints

It has been recognized that a primary method of further enhancing the downlink spectral efficiency of LTE Release-10 is to introduce support for coordinated multi-point (CoMP) transmission. This paper investigates the performance improvements due to downlink CoMP within the framework of LTE (specifically LTE Release-11). A realistic estimate of achievable CoMP throughput performance is provided with respect to variations in deployment scenario, amount of feedback information and at different traffic loads. It is observed that the performance gains due to CoMP are limited to cell edge UE (user equipment) throughput improvements of up to 30%. Further, we show that dynamic cell selection can realize most of the CoMP gains with less feedback than joint transmission and it is more robust under practical conditions.
Shadow Activity and Unemployment in a Depressed Labour Market

This Paper studies the border between shadow employment and unemployment. It argues that the two macroeconomic phenomena are two faces of the same coin: any policy aimed at reducing the former will increase the latter. Theoretically, it proposes and solves a matching model of the labour market, where shadow employment emerges in equilibrium as the endogenous response of firms and workers who felt overburdened by taxes and regulations. While the model we propose neatly rationalizes the labour market trade-off implied by ‘shadow reducing policies’, it suggests that economies with low unemployment turnover should be characterized also by low turnover along the shadow margins. Since existing estimates of shadow employment are silent on labour market flows and on the relation between shadow activity and the main labour market aggregates, we perform original empirical work on the border between employment, unemployment and inactivity, and we find that Italian shadow employment has longer duration in regions with lower unemployment turnover. We also find support to the substantive assumptions of the model.
Demographics of Deaf Education: More Students in More Places

We have witnessed important changes in the demographics of the deaf and hard of hearing student population receiving special education services during the past quarter century. The ethnic, intervention, and educational setting profiles are more diverse and dispersed. On top of the federal policy changes driving emerging intervention and continuing educational setting changes, there is now an increasing demand for deaf and hard of hearing students to participate in the general curriculum and school accountability systems. Over the same time period, stricter control over student data privacy and greater scrutiny of human subject protection have been incorporated into federal regulations. We highlight some consequences for deaf education research resulting from the convergences of these parallel trends in changing demographics, shifting school policy contexts, and regulation of federally funded research.
Lewy bodies in psychiatric patients

This investigation concerns the mental changes associated with Lewy bodies. Lewy bodies are inclusion bodies found in nerve cells and are characteristic of idiopathic Parkinson's disease. It has also been suggested that they may occur as a normal ageing change. Previous literature concerning the psychiatric symptoms of Lewy body disease is reviewed. Dementia and parkinsonism‐associated depression have been previously recognized. For this study the psychiatric histories of two groups of autopsied mental hospital patients were compared; one group with Lewy bodies, and one group without Lewy bodies. There were 212 autopsies. Of these, 15 had Lewy bodies and 197 did not. Clinical and neuropathological descriptions of those with Lewy bodies are given. Findings are also presented in tabulated form, and the groups are compared statistically. Clinical diagnosis of Parkinson's disease and admission with a paranoid diagnosis were the findings most associated with Lewy bodies. It is suggested that paranoia may sometimes be an early symptom of Lewy body disease. The problem of patients with psychosis who subsequently develop idiopathic Parkinson's disease is discussed. Such patients could be misidentified and mistreated because of being diagnosed as drug‐induced parkinsonism.
Biocompatible Bacterial Cellulose-Poly(2-hydroxyethyl methacrylate) Nanocomposite Films

A series of bacterial cellulose-poly(2-hydroxyethyl methacrylate) nanocomposite films was prepared by in situ radical polymerization of 2-hydroxyethyl methacrylate (HEMA), using variable amounts of poly(ethylene glycol) diacrylate (PEGDA) as cross-linker. Thin films were obtained, and their physical, chemical, thermal, and mechanical properties were evaluated. The films showed improved translucency compared to BC and enhanced thermal stability and mechanical performance when compared to poly(2-hydroxyethyl methacrylate) (PHEMA). Finally, BC/PHEMA nanocomposites proved to be nontoxic to human adipose-derived mesenchymal stem cells (ADSCs) and thus are pointed as potential dry dressings for biomedical applications.
Gender Differences in Environmental Values

Increasingly, researchers are focusing on the study of environmental values of young people. Indeed, it is today’s youth who will be the decision makers in the future. Attention has turned to explaining individual differences in this construct, and many authors have illustrated gender differences. The current study (N = 1,285, 10- to 12-year-olds) compares results of a classical analytical approach to quantifying such differences (independent samples t tests) with one of measurement and structural invariance across genders. The essential difference between the two is that whereas the latter controls for differential item functioning across gender, the first does not. The results show that whereas gender differences in utilization values occur when applying a classic analytical approach, they do not occur through the invariance approach. These results suggest that other studies that demonstrated gender differences might be explained by differential item functioning rather than reflect genuine differences, and might thus represent methodological artifacts.
Treadmill Exercise Training Improves Vascular Endothelial Growth Factor Expression in the Cardiac Muscle of Type I Diabetic Rats

Background Vascular endothelial growth factor (VEGF) expression is a potent mitogen for endothelial cells that is involved in angiogenesis. Cardiac VEGF is decreased in many pathologic conditions, including diabetes mellitus and aging. Exercise training has improved VEGF expression in the aging heart. Thus, the aim of our study is to illustrate the impact of treadmill exercise training on the cardiac VEGF expression in type I diabetic rats. Methods Twenty normal Sprague-Dawley rats and Sprague-Dawley rats with streptozotocin-induced diabetes were divided into the following equal groups: sedentary control (SC), exercised control (EC), sedentary diabetic rats (SD) and exercised diabetic rats (ED). Immunohistochemistry was used to investigate VEGF expression in the cardiac tissue in each of the four different groups. Results Cardiac VEGF expression was significantly (P < 0.05) lower in SD compared with that in SC. However, exercise training significantly (P < 0.01) enhanced VEGF expression in the cardiac tissue in ED compared with that in SD. Conclusion Our present data suggest that treadmill exercise training improved diabetes-induced downregulation in the cardiac VEGF expression.
Involvement of Actin Rearrangements within the Amygdala and the Dorsal Hippocampus in Aversive Memories of Drug Withdrawal in Acute Morphine-Dependent Rats

Aversive memories of drug withdrawal can generate a motivational state leading to compulsive drug taking. Changes in synaptic plasticity may be involved in the formation of aversive memories. Dynamic rearrangement of the cytoskeletal actin, a major structural component of the dendritic spine, regulates synaptic plasticity. Here, the potential involvement of actin rearrangements in the induction of aversive memories of morphine withdrawal was examined. We found that lesions of the amygdala or dorsal hippocampus (DH) but not nucleus accumbens (NAc) impaired conditioned place aversion (CPA) of acute morphine-dependent rats. Accordingly, conditioned morphine withdrawal induced actin rearrangements in the amygdala and the DH but not in the NAc. In addition, we found that conditioned morphine withdrawal also increased activity-regulated cytoskeletal-associated protein (Arc) expression in the amygdala but not in the DH, although actin rearrangements were observed in both areas. We further found that inhibition of actin rearrangements by intra-amygdala or intra-DH injections of latrunculin A, an inhibitor of actin polymerization, significantly attenuated CPA. Furthermore, we found that manipulation of amygdala β-adrenoceptor activity by its antagonist propranolol and agonist clenbuterol differentially altered actin rearrangements in the DH. Therefore, our findings reveal that actin rearrangements in the amygdala and the DH are required for the acquisition and consolidation of the aversive memories of drug withdrawal and that the β-noradrenergic system within the amygdala modulates aversive memory consolidation by regulating actin rearrangements but not Arc protein expression in the DH, which is distinct from its role in modulation of inhibitory avoidance memory.
Effect of a single nucleotide polymorphism in miR-146a on COX-2 protein expression and lung function in smokers with chronic obstructive pulmonary disease

Objective To evaluate the effect of a single nucleotide polymorphism (rs2910164) in the miR-146a precursor on the expression level of miR-146a, cyclooxygenase-2 (COX2), and production of prostaglandin E2 (PGE2) in lung tissue harvested from smokers with chronic obstructive pulmonary disease, as well as the lung function and disease stages from the same patient population. Methods and results One-hundred and sixty-eight smokers with diagnosed chronic obstructive pulmonary disease were recruited. The patients were genotyped for rs2910164 polymorphism using Sanger sequencing, and their lung function/disease stages were evaluated following Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria. Meanwhile, messenger ribonucleic acid and protein expression levels of miR-146a and COX2 as well as PGE2 production were determined in 66 lung tissue samples collected in the patients who received surgical treatment. We confirmed that COX2 is a validated target of miR-146a in human fibroblast cells, and identified the differential expression patterns of miR-146a and COX2 in each rs2910164 genotype group. We observed a significant association between rs2910164 in miR-146a and the levels of either COX2 or PGE2 using real-time polymerase chain reaction and Western blot. Consistently, we were able to demonstrate that the rs2910164 single nucleotide polymorphism has a functional effect on the baseline lung function in the study population. Conclusion In the present study, the rs2910164 CC and GC genotype was found to be associated with an improved lung function and milder disease stages, at least partially, mediated by its ability to increase in COX2 expression and PGE2 production.
Quality of Maternal and Neonatal Care in Albania, Turkmenistan and Kazakhstan: A Systematic, Standard-Based, Participatory Assessment

Background Progress in maternal and neonatal mortality has been slow in many countries despite increasing access to institutional births, suggesting deficiencies in the quality of care. We carried out a systematic assessment of the quality of maternal and newborn care in three CEE/CIS countries, using an innovative approach to identify priority issues and promote action. Methods A standard-based tool, covering over 400 items grouped in 13 main areas ranging from support services to case management, was used to assess a sample of ten maternity hospitals in Albania, Kazakhstan and Turkmenistan. Sources of information were visit to services, medical records, observation of cases, and interviews with staff and mothers. A score (range 0 to 3) was attributed to each item and area of care. The assessment was carried out by a multidisciplinary team of international and national professionals. Local managers and staff provided the necessary information and were involved in discussing the findings and the priority actions. Results Quality of care was found to be substandard in all 13 areas. The lowest scores (between one and two) were obtained by: management of normal labour, delivery, obstetric complications and sick babies; infection prevention; use of guidelines and audits; monitoring and follow-up. Neonatal care as a whole scored better than obstetric care. Interviewed mothers identified lack of information, insufficient support during labour and lack of companionship as main issues. Actions to improve quality of care were identified at facility as well as at central level and framed according to main health system functions. Conclusions Quality of care is a key issue to improve maternal and neonatal outcomes, particularly in countries such as CEE/CIS where access to institutional births is nearly universal. Approaches that involve health professionals and managers in comprehensive, action-oriented assessments of quality of care are promising and should be further supported.
Examining the Effect of the LET'S ACT Behavioral Activation Treatment for Depression on Substance Abuse Treatment Dropout

Title of Document: EXAMINING THE EFFECT OF THE LET’S ACT BEHAVIORAL ACTIVATION TREATMENT FOR DEPRESSION ON SUBSTANCE ABUSE TREATMENT DROPOUT Jessica F. Magidson, Master of Science, 2010 Directed By: Carl W. Lejuez, Professor, Department of Psychology Despite the prevalence of depression among substance users and the negative impact of depressive symptoms on substance abuse treatment outcomes, few interventions have been developed to meet the needs of depressed substance users, particularly in lowincome urban areas. The current study aimed to replicate and expand upon promising preliminary findings for the use of a brief behavioral activation approach [Life Enhancement Treatment for Substance Use (LET’S ACT; Daughters et al., 2008)] to treat depression in the context of residential substance abuse treatment. Extensions to the previous study include comparing LET’S ACT to a contact-time matched control treatment, Supportive Counseling (SC), and more definitively evaluating the effect of LET’S ACT on substance abuse treatment dropout. Results indicated that compared to SC, participants in LET’S ACT evidenced significantly lower rates of treatment dropout and depressive symptoms, as well as significantly higher rates of behavioral activation. This study builds on evidence for LET’S ACT as a short-term treatment for depression and offers initial support for the effect of LET’S ACT on substance use outcomes.
The Politics of Stakeholder Theory: Some Future Directions

Abstract: The purpose of this paper is to enter the conversation about stakeholder theory with the goal of clarifying certain foundational issues. I want to show, along with Boatright, that there is no stakeholder paradox, and that the principle on which such a paradox is built, the Separation Thesis, is nicely self-serving to business and ethics academics. If we give up such a thesis we find there is no stakeholder theory but that stakeholder theory becomes a genre that is quite rich. It becomes one of many ways to blend together the central concepts of business with those of ethics. Rather than take each concept of business singly or the whole of “business” together and hold it to the light of ethical standards, we can use the stakeholder concept to create more fine-grained analyses that combine business and ethics; or more simply, we can tell many more, and more interesting, stories about business.
Predicting Costs of Care Using a Pharmacy-Based Measure Risk Adjustment in a Veteran Population

Background. Although most widely used risk adjustment systems use diagnosis data to classify patients, there is growing interest in risk adjustment based on computerized pharmacy data. The Veterans Health Administration (VHA) is an ideal environment in which to test the efficacy of a pharmacy-based approach. Objective. To examine the ability of RxRisk-V to predict concurrent and prospective costs of care in VHA and compare the performance of RxRisk-V to a simple age/gender model, the original RxRisk, and two leading diagnosis-based risk adjustment approaches: Adjusted Clinical Groups and Diagnostic Cost Groups/Hierarchical Condition Categories. Methods. The study population consisted of 161,202 users of VHA services in Washington, Oregon, Idaho, and Alaska during fiscal years (FY) 1996 to 1998. We examined both concurrent and predictive model fit for two sequential 12-month periods (FY 98 and FY 99) with the patient-year as the unit of analysis, using split-half validation. Results. Our results show that the Diagnostic Cost Group /Hierarchical Condition Categories model performs best (R2 = 0.45) among concurrent cost models, followed by ADG (0.31), RxRisk-V (0.20), and age/sex model (0.01). However, prospective cost models other than age/sex showed comparable R2: Diagnostic Cost Group /Hierarchical Condition Categories R2 = 0.15, followed by ADG (0.12), RxRisk-V (0.12), and age/sex (0.01). Conclusions. RxRisk-V is a clinically relevant, open source risk adjustment system that is easily tailored to fit specific questions, populations, or needs. Although it does not perform better than diagnosis-based measures available on the market, it may provide a reasonable alternative to proprietary systems where accurate computerized pharmacy data are available.
Why Has US Drug Policy Changed So Little over 30 Years?

Though almost universally criticized as overly punitive, expensive, racially disparate in impact, and ineffective, American drug policy remained largely unchanged from 1980 to 2010. Marijuana is an important exception: policy and law underwent many changes, with the strong likelihood of more, involving increased legal access to the drug, in the near future. For cocaine, heroin, and methamphetamine there has been an almost relentless increase in the numbers incarcerated for drug offenses, rising from about 50,000 in 1980 to 500,000 in 2010. The disparities in African American imprisonment rates are higher for drug offenses than for other types of crime; some of this disparity results from unjustifiably harsher sentences for crack than for powder cocaine offenses. The battles necessary to achieve even modest reductions in these disparities and other overly severe sentencing regimes at the state and federal levels demonstrate how difficult it is to achieve changes in drug policy. Recent reforms in health care at the federal level offer hope for increased access to treatment services, but otherwise only drug policy rhetoric has changed much.
Title An excitatory GABA loop operating in vivo

and Llano. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. While it has been proposed that the conventional inhibitory neurotransmitter GABA can be excitatory in the mammalian brain, much remains to be learned concerning the circumstances and the cellular mechanisms governing potential excitatory GABA action. Using a combination of optogenetics and two-photon calcium imaging in vivo, we find that activation of chloride-permeable GABA A receptors in parallel fibers (PFs) of the cerebellar molecular layer of adult mice causes parallel fiber excitation. Stimulation of PFs at submaximal stimulus intensities leads to GABA release from molecular layer interneurons (MLIs), thus creating a positive feedback loop that enhances excitation near the center of an activated PF bundle. Our results imply that elevated chloride concentration can occur in specific intracellular compartments of mature mammalian neurons and suggest an excitatory role for GABA A receptors in the cerebellar cortex of adult mice.
Dysregulation and functional roles of miR-183-96-182 cluster in cancer cell proliferation, invasion and metastasis

Previous studies have reported aberrant expression of the miR-183-96-182 cluster in a variety of tumors, which indicates its' diagnostic or prognostic value. However, a key characteristic of the miR-183-96-182 cluster is its varied expression levels, and pleomorphic functional roles in different tumors or under different conditions. In most tumor types, the cluster is highly expressed and promotes tumorigenesis, cancer progression and metastasis; yet tumor suppressive effects have also been reported in some tumors. In the present study, we discuss the upstream regulators and the downstream target genes of miR-183-96-182 cluster, and highlight the dysregulation and functional roles of this cluster in various tumor cells. Newer insights summarized in this review will help readers understand the different facets of the miR-183-96-182 cluster in cancer development and progression.