Miracle-dz/UniFAR-FTUs huggingface dataset:
Differences in miRNA Expression in Early Stage Lung Adenocarcinomas that Did and Did Not Relapse

Relapse of adenocarcinoma, the most common non-small cell lung cancer (NSCLC), is a major clinical challenge to improving survival. To gain insight into the early molecular events that contribute to lung adenocarcinoma relapse, and taking into consideration potential cell type specificity, we used stringent criteria for sample selection. We measured miRNA expression only from flash frozen stage I lung adenocarcinomas, excluding other NSCLC subtypes. We compared miRNA expression in lung adenocarcinomas that relapsed within two years to those that did not relapse within three years after surgical resection prior to adjuvant therapy. The most significant differences in mRNA expression for recurrent tumors compared to non-recurrent tumors were decreases in miR-106b*, -187, -205, -449b, -774* and increases in miR-151-3p, let-7b, miR-215, -520b, and -512-3p. A unique comparison between adjacent normal lung tissue from relapse and non-relapse groups revealed dramatically different miRNA expression, suggesting dysregulation of miRNA in the environment around the tumor. To assess patient-to-patient variability, miRNA levels in the tumors were normalized to levels in matched adjacent normal lung tissue. This analysis revealed a different set of significantly altered miRNA in tumors that recurred compared to tumors that did not. Together our analyses elucidated miRNA not previously linked to lung adenocarcinoma that likely have important roles in its development and progression. Our results also highlight the differences in miRNA expression in normal lung tissue in adenocarcinomas that do and do not recur. Most notably, our data identified those miRNA that distinguish early stage tumors likely to relapse prior to treatment and miRNA that could be further studied for use as biomarkers for prognosis, patient monitoring, and/or treatment decisions.
Behavioral Neuroscience

(between ∼ 0.6 and 1 Hz in the type of isolated CNS preparation we used in the present study) to carry out their normal (non-learning) modulatory role in supporting feeding motor output (Yeoman et al., 1994). Membrane potential depolarization already has been linked to a learning-induced increase of the persistent sodium current (I NaP) of the CGCs (Nikitin et al., 2008), but the mechanism of spike frequency stabilization remained unknown. To facilitate our understanding of the electrical mechanisms underlying this novel combination of plasticity and stability of key electrical properties in the same neuron, here we used voltage and current-clamp data as inputs to parameter estimation in a single-compartment Hodgkin-Huxley-type model of the CGCs. The parameterized model is then validated against different data and its behavior correlated to that observed in the CGCs after conditioning. Our main specifi c aim was to replicate the complex electrophysi-ological effects of behavioral conditioning by simulating changes in I NaP and the delayed rectifi er potassium current (I D) of the CGCs (Staras et al., 2002). The inclusion of I D in the modeling was justifi ed by the fi nding that this current is also increased following conditioning (see Results). This new fi nding allowed us to formulate the hypothesis that a balanced increase in the conductances of I D and
Intelligent word-prediction to enhance text input rate (a syntactic analysis-based word-prediction aid for people with severe motor and speech disability)

ADSTRACT Word-prediction is a technique commonly used to reduce the amount of keystrokes needed to input text by people with severe physical disabilities. Several methods based on word frequencies have been developed so far. Many of them do not take advantage of the information inherent to the syntactic sentence structure. This paper puts forth a word-prediction method based on the syntactical analysis of a sentence, carried out using the “chart” parsing method proposed by Allen. This method also adapts its behaviour to the user’s lexicon. The obtained results are compared to others obtained from a pure statistical predictor,
International Journal for Numerical Methods in Fluids Higher-order Finite Element Discretizations in a Benchmark Problem for Incompressible Flows

SUMMARY We present a numerical study of several finite element discretizations applied to a benchmark problem for the two-dimensional steady state incompressible Navier– Stokes equations defined in Schäfer and Turek (The benchmark problem 'Flow around a cylinder'. In Flow Simulation with High-Performance Computers II. 547–566). The discretizations are compared with respect to the accuracy of the computed benchmark parameters. Higher-order isoparametric finite element discretizations turned out to be by far the most accurate. The discrete systems obtained with higher-order discretizations are solved with a modified coupled multigrid method whose behaviour within the benchmark problem is also studied numerically.
Eigenvalue variance bounds for covariance matrices

This work is concerned with finite range bounds on the variance of individual eigenvalues of random covariance matrices, both in the bulk and at the edge of the spectrum. In a preceding paper, the author established analogous results for Wigner matrices and stated the results for covariance matrices. They are proved in the present paper. Relying on the LUE example, which needs to be investigated first, the main bounds are extended to complex covariance matrices by means of the Tao, Vu and Wang Four Moment Theorem and recent localization results by Pillai and Yin. The case of real covariance matrices is obtained from interlacing formulas.
Dissociable Executive Functions in the Dynamic Control of Behavior: Inhibition, Error Detection, and Correction

The present study employed event-related fMRI and EEG to investigate the biological basis of the cognitive control of behavior. Using a GO/NOGO task optimized to produce response inhibitions, frequent commission errors, and the opportunity for subsequent behavioral correction, we identified distinct cortical areas associated with each of these specific executive processes. Two cortical systems, one involving right prefrontal and parietal areas and the second regions of the cingulate, underlay inhibitory control. The involvement of these two systems was predicated upon the difficulty or urgency of the inhibition and each was employed to different extents by high- and low-absent-minded subjects. Errors were associated with medial activation incorporating the anterior cingulate and pre-SMA while behavioral alteration subsequent to errors was associated with both the anterior cingulate and the left prefrontal cortex. Furthermore, the EEG data demonstrated that successful response inhibition depended upon the timely activation of cortical areas as predicted by race models of response selection. The results highlight how higher cognitive functions responsible for behavioral control can result from the dynamic interplay of distinct cortical systems.
Management and Administration in Education: What do school heads do? A focus on primary school heads in one district in Zimbabwe.

A study was conducted in twenty primary schools in Chegutu Education District of Zimbabwe. The purpose of the study was to establish the perceptions of primary school heads on administration and management of schools in Zimbabwe. It further sought to establish the extent to which primary school heads were conversant with their duties and responsibilities and whether they viewed themselves as either school administrators or school managers or both. The study used the qualitative research methodology. Data was collected through the use of open-ended questionnaires, interviews and document analysis. The study used purposive sampling and came up with twenty schools whose school heads became respondents. Among other things the study indicated that there was no clear distinction between administration and management among the school heads. At the same time, it was noted that administrative responsibilities tended to consume school heads’ time to the extent of ignoring management functions and instructional leadership roles. It was also noted that allocating a school head a class compromised pupils’ learning as the school heads were often away from the station on school business. It was also noted that some school heads tended to over-burden themselves with responsibilities as they were reluctant to delegate duties. In instances they delegated, they tended to delegate peripheral responsibilities. The study recommends that the roles of administrator and manager be performed by two different people in schools. It further recommends that school heads should not be allocated classes or required to teach specific number of periods as such classes tended to suffer in the absence of the school head on school administrative and management business.
Psychopathic Personality Disorder

The diagnosis of psychopathic personality disorder has salience for forensic clinical practice. It influences decisions regarding risk, treatability and sentencing, indeed, in certain jurisdictions it serves as an aggravating factor that increases the likelihood of a capital sentence. The concatenation of symptom that is associated with modern conceptions of the disorder can be discerned in early writings, including the book of Psalms. Despite its forensic clinical importance and historical pedigree the concept remains elusive and controverted. In this paper I describe an attempt to map the concept of psychopathic personality disorder—the Comprehensive Assessment of Psychopathic Personality (CAPP). I outline the processes used to create the concept map; I summarise evidence in support of the content validity of the map and describe different operations designed to operationalise the construct. It is only when conceptual clarity is achieved that valid operations and measures can be created. I end with a plea for more carefully considered application of statistical methods; applications that better fit the theoretical questions being posed.
Design of Compensated Coupled-Stripline 3-dB Directional Couplers, Phase Shifters, and Magic-T's&#8212;Part I: Single-Section Coupled-Line Circuits

The problem of discontinuities in coupled-stripline 3-dB directional couplers, phase shifters, and magic-T's, regarding the connections of coupled and terminating signal lines, has been comprehensively investigated for the first time. The proposed equivalent circuit of these discontinuities, of which parameters can be computed in a process of fitting curves of the circuit and electromagnetic analyses, has been used for accurate modeling of coupled-stripline circuits. It has been shown that parasitic reactances, which result from connections of signal and coupled lines, severely deteriorate the return losses and the isolation of such circuits, and that these discontinuity effects can be substantially reduced by connecting compensating shunt capacitances to both coupled and signal lines. Results of measurements carried out for various designed and manufactured coupled-line circuits are most promising and prove the efficiency of the proposed compensation technique. This paper describes the technique of capacitive compensation of discontinuity effects in single-section coupled-line circuits
Interactions in IS Project Portfolio Selection - Status Quo and Perspectives

One central and important requirement for IS project portfolio selec- tion is the adequate consideration of project interactions. However, the IS disci- pline notably lacks a common understanding of the nature of project interac- tions and their impact on IS project portfolio selection. To remedy this we con- duct a systematic and interdisciplinary literature review thereby providing a starting point for a cumulative research tradition. The main contribution of this paper is the development of a taxonomy to summarize the current state-of-the- art. Thereby, we provide a basis enabling researchers to develop integrated ap- proaches. Based on the identified research gaps we formulate a research agenda for the field of IS project portfolio selection considering interactions.
Evaluation of the Xinanjiang model structure by observed discharge and gauged soil moisture data in the HUBEX/GAME project

Based upon the sense that the use of an inadequate model structure may be more problematic than the use of sub-optimal parameter values, the experience and progress in the HUaihe River Basin EXperiment (HUBEX) during the intensified observation period from 1998 to 1999, as a component of the GEWEX (Global Energy and Water Cycle EXperiment) Asian Monsoon Experiment (GAME) Project, is reported in this paper. It focuses on the realism of the Xinanjiang model structure evaluated not only by discharge hydrographs observed upstream (Huangnizhuang station) and downstream (Jiangji station), but also by volumetric soil moisture data gauged at three sites, Meishan, Nianyushan, and Jiangji. The Xinanjiang model was applied to subcatchments derived from the digital elevation data for runoff generation. The Muskingum method was used for the routing of discharge from the outlet of each subcatchment to the outlet of the whole studied catchment. Soil tension water storage at each time interval computed by the Xinanjiang model, in millimetres is in good agreement with soil moisture data time series gauged in the field. Their correlation coefficients range from 0.810 to 0.867. The results show that the values of soil tension water storage in the Xinanjiang model can represent temporal variability of the soil moisture state variable within the subcatchments, reflecting wet or dry situations in the real world. That, to some extent, answers the question of how far the internal model state relates to real world variables.
Child well-being when fathers return from prison

ABSTRACT A majority of men incarcerated are fathers, but little research has been conducted on the children’s well-being after their father’s release from incarceration. We measured changes in internalizing and externalizing problems (based on father’s and female partner’s report) across a 34-month period among children ages 6–17 (n = 431). Results suggested increased internalizing and externalizing problems in older children, increased internalizing problems when fathers had problem alcohol use, and a moderating role of father–child coresidence and father–child relationship. Programs to promote paternal well-being and father–child relationships before and after reentry may benefit children of incarcerated fathers.
Clinical Validation of Integrated Nucleic Acid and Protein Detection on an Electrochemical Biosensor Array for Urinary Tract Infection Diagnosis

Background Urinary tract infection (UTI) is a common infection that poses a substantial healthcare burden, yet its definitive diagnosis can be challenging. There is a need for a rapid, sensitive and reliable analytical method that could allow early detection of UTI and reduce unnecessary antibiotics. Pathogen identification along with quantitative detection of lactoferrin, a measure of pyuria, may provide useful information towards the overall diagnosis of UTI. Here, we report an integrated biosensor platform capable of simultaneous pathogen identification and detection of urinary biomarker that could aid the effectiveness of the treatment and clinical management. Methodology/Principal Findings The integrated pathogen 16S rRNA and host lactoferrin detection using the biosensor array was performed on 113 clinical urine samples collected from patients at risk for complicated UTI. For pathogen detection, the biosensor used sandwich hybridization of capture and detector oligonucleotides to the target analyte, bacterial 16S rRNA. For detection of the protein biomarker, the biosensor used an analogous electrochemical sandwich assay based on capture and detector antibodies. For this assay, a set of oligonucleotide probes optimized for hybridization at 37°C to facilitate integration with the immunoassay was developed. This probe set targeted common uropathogens including E. coli, P. mirabilis, P. aeruginosa and Enterococcus spp. as well as less common uropathogens including Serratia, Providencia, Morganella and Staphylococcus spp. The biosensor assay for pathogen detection had a specificity of 97% and a sensitivity of 89%. A significant correlation was found between LTF concentration measured by the biosensor and WBC and leukocyte esterase (p<0.001 for both). Conclusion/Significance We successfully demonstrate simultaneous detection of nucleic acid and host immune marker on a single biosensor array in clinical samples. This platform can be used for multiplexed detection of nucleic acid and protein as the next generation of urinary tract infection diagnostics.
Phenotypic and Genotypic Characteristics of Members of the Genus Streptobacillus

The genus Streptobacillus (S.) remained monotypic for almost 90 years until two new species were recently described. The type species, S. moniliformis, is one of the two etiological agents of rat bite fever, an under-diagnosed, worldwide occurring zoonosis. In a polyphasic approach field isolates and reference strains of S. moniliformis, S. hongkongensis, S. felis as well as divergent isolates were characterized by comparison of molecular data (n = 29) and from the majority also by their physiological as well as proteomic properties (n = 22). Based on growth-independent physiological profiling using VITEK2-compact, API ZYM and the Micronaut system fastidious growth-related difficulties could be overcome and streptobacilli could definitively be typed despite generally few differences. While differing in their isolation sites and dates, S. moniliformis isolates were found to possess almost identical spectra in matrix-assisted laser desorption ionization—time of flight mass spectrometry and Fourier transform infrared spectroscopy. Spectroscopic methods facilitated differentiation of S. moniliformis, S. hongkongensis and S. felis as well as one divergent isolate. Sequencing of 16S rRNA gene as well as functional genes groEL, recA and gyrB revealed only little intraspecific variability, but generally proved suitable for interspecies discrimination between all three taxa and two groups of divergent isolates.
Investigating the Needs to Develop an Integrated Holistic Marriage Education Module (IHMEM)

Due to the escalating statistical figure of divorce rate amongst Muslim couples in Malaysia, there is a need to enhance the marriage education program to be more effective in overcoming the problems of marriage, as well as to provide the knowledge and skills to the spouse and to prevent the divorce cases. Therefore, this article is aimed to explore the views of experts and couples with marital conflict on the needs of marriage education in Malaysia. This article employed an interview method with ten participants; amongst them are five Consultation Officer from the Islamic Religious Office and five people who are facing marital conflict and seeking advice from the Islamic Religious Office. The data collected between March until June 2016 and were managed and analyzed using thematic analysis approach. The findings of the interviews revealed two main outcomes (i) the views of experts and conflict people about marriage education; (ii) the views of experts and conflict people on the content of marriage education course. The findings highlight that marriage education course is important to provide a platform for knowledge and relationship skills between husband and wife. Various topics need to be included in preparing the module of marriage education, such as financial management, conflict management skills, effective communication skills, listening and express feelings skills.
'Black women' therapists' impressions of the social differences of 'race' and gender in the therapeutic process : a post-structuralist phenomenology narrative exploration

“Thinking about congruence implies [thinking] about difference…If there was no difference there would be no process and [therapeutic] progress. ” Schmid, 2001p218 This study uses a hermeneutic phenomenological approach incorporating post-structuralist principles to explore ‘Black’ women therapists’ accounts of their lived experience of social differences (race and gender) in their clinical practice. It aims to provide rich descriptions of the women’s experiences, which are understood as grounded in wider socio-political processes and contexts. This methodological approach was adopted to acknowledge the socially constructed nature of race and gender and reduce the reification of these terms. It allows an explicit focus on the experiences of ’black’ female therapists in their clinical interactions with white male clients, including the extent where these social differences impact on therapists’ concepts of self and the developing therapeutic relationship with white male clients. Ten ‘black’ women psychotherapists from different therapeutic orientations and working in a range of contexts were interviewed about their experiences of working with white male clients. Three distinct but interrelated narrative structures emerged as prominent across the participants' accounts: race and gender as markers of difference; relating through difference; and finding self beyond social division. The study found race and gender, as intersecting contextual factors, could influence therapists’ ‘self-states’ and meaning-constructions within the therapeutic relationship. For most participants, race-related issues were more present than gender-related ones; participants’ accounts underlined the prominence of the internal psychological challenges they experienced when engaging with racial issues in the therapeutic process. In contrast to identity developmental model, the findings suggest therapists' identification with these categories is better understood by the use of subjectivity and positionality, concepts derived from post-structuralist discourse. Such use highlights the shifting, fluid and temporal nature of these social processes. Participants’ accounts suggested that self-reflexivity and relational forms of reflexivity allowed them to find ‘self’ in the context of race and gender differences with clients. Highlighting the significance of these factors for ‘black’ female therapists and the importance of addressing difference related to race and gender within training. The study concludes by making recommendations for the normalising and validation of therapists’ experiences in supervision and training, so that ‘black’ female therapists can be supported to find ‘self’ beyond the social divisions they may encounter in their practice.