Miracle-dz/UniFAR-FTUs huggingface dataset:
The demographics of significant firearm injury in Canadian trauma centres and the associated predictors of inhospital mortality.

OBJECTIVE Our primary objective was to evaluate demographic and causal factors of inhospital mortality for significant firearm-related injuries (i.e., those with an Injury Severity Score [ISS] > 12) in Canadian trauma centres. METHODS We analyzed data submitted to the Canadian Institute for Health Information (CIHI) in the National Trauma Registry for all firearm-injured patients for fiscal years 1999-2003. Univariate and bivariate adjusting for ISS and multivariate logistic regression were performed. RESULTS Men accounted for 94% of the 784 injured. In all patients, the percentages of self-inflicted, intentional, unintentional and unknown injuries were 27.8%, 60.3%, 6.1% and 5.7%, respectively. The inhospital fatality rate was 39.8%, with 83% of fatalities occurring on the first day. Two-thirds of patients were discharged home. Univariate and adjusted analysis found that ISS, first systolic blood pressure (BP), first systolic BP under 100, first Glasgow Coma Scale (GCS) score, age over 45 years, self-inflicted injury, intentional injury and injury at home significantly worsened the odds ratio of death in hospital and that police shooting was relatively beneficial. BP under 100, age over 45 years and a low GCS score had an adjusted odds ratio of death of 4.12, 1.99 and 0.64 per point increase, respectively. The multivariate model showed that ISS, BP under 100, first GCS score, sex and self-inflicted injury were significant in predicting inhospital death. CONCLUSION A predominance of young men are injured intentionally with handguns in Canada, whereas older patients suffer self-inflicted injuries with long guns. The significant number of firearm deaths, largely in the first day, highlights the importance of preventative strategies and the need for rapid transport of patients to trauma centres for urgent care.
Carboplatin: an active drug in metastatic breast cancer.

PURPOSE The study was undertaken to assess the antitumor activity of carboplatin 400 mg/m2 intravenously every 4 weeks in metastatic breast cancer (MBC). PATIENTS AND METHODS Thirty-four MBC patients without any prior exposure to chemotherapy entered the study. All patients had measurable disease in at least one site and were assessable for response and toxicity. RESULTS Of 34 assessable patients, 12 obtained a complete (one) or partial (11) response to carboplatin, resulting in an overall response rate of 35% (95% confidence interval, 19.8% to 53.5%). The median duration of response was 8 months (range, 2+ to 12 months). Responses were seen in lymph nodes (four of six), lung (five of nine), skin and soft tissues (four of nine), breast (two of eight), and liver (three of 11), but not in measurable lytic lesions of the bone. Toxicity was mild, mainly consisting of emesis (81% of the patients; 66% of the courses), leukopenia of World Health Organization (WHO) grade 1 to 2 (47% of the patients; 18% of the courses), and thrombocytopenia (12% of the patients; 3% of the courses). There were no cases of life-threatening toxicity, although one patient developed grade 4 thrombocytopenia without bleeding. Of 22 patients who did not respond to carboplatin, 18 received salvage therapy with cyclophosphamide, doxorubicin, and fluorouracil (CAF; 15 patients); cyclophosphamide, methotrexate, and fluorouracil (CMF; one patient); or hormones (two patients). Objective responses to CAF and hormonal therapy were seen in 11 of 15 and two of two patients, respectively. The remaining patient did not respond to CMF salvage chemotherapy. Overall, the response rate to either first-line carboplatin or second-line salvage therapy was 73.5% (25 of 34 patients). After a median follow-up time of 22 months, the median survival was 19 months. CONCLUSIONS Carboplatin is an active drug in MBC patients without previous exposure to chemotherapy. In our study, the use of an experimental drug as first-line single-agent treatment in MBC did not have a negative influence on patient survival, as the majority of the carboplatin nonresponding patients could be salvaged with a conventional therapeutic regimen.
Subtypes of Emotional and Behavioural Sequelae in Patients With Traumatic Brain Injury

This study examined patterns of emotional and behavioural sequelae in 300 individuals who sustained a traumatic brain injury (TBI). Participants were obtained through the Adult Acquired Brain Injury Program at Chedoke Hospital in Hamilton, Ontario, based on the following inclusionary criteria: (1) single incident of TBI; (2) no history of additional neurological diseases; (3) time postinjury =8.5 years; (4) WAIS-R FSIQ >85 and/or estimated reading skills above grade 5 level; and (5) valid Minnesota Multiphasic Personality Inventory (MMPI) profiles (i.e., F <90, L <66, and K <66). MMPI profiles of these individuals, in randomly split samples of 150 per group, were subjected to a three-step cluster analytic approach. A six-cluster solution was adequately replicated across samples and across clustering techniques. The identified subtypes included profiles indicative of: (1) no concerns or normal functioning; (2) mild somatic and pain concerns; (3) mild internalizing difficulties; (4) marked disinhibition and externalizing behavioural difficulties; (5) marked internalizing difficulties; and (6) marked somatic, internalizing, and externalizing behavioural disturbances. Members of the Externalized subtype were significantly younger in age than those in the other five subtypes, and more likely to be single than those in the Internalized subtype. Individuals in the Internalized subtype tended to be married, have longer times postaccident, and lower WAIS-R Verbal Intelligence Quotients than those comprising the Normal subtype.
Infant temperament, pleasure in parenting, and marital happiness in adoptive families

Les caracteriques du temperament ont ete liees a des resulats ulterieurs d'externalisation et d'internalisation du comportement. Afin d'evaluer la relation entre le temperament et le milieu familial du nourrisson, nous avons mesure le temperament du nourrisson, le plaisir dans le parentage et le bonheur conjugal grâce a des rapports faits par les parents dans 99 familles avec un enfant adopte et non issu de la famille. Les perceptions du temperament de l'enfant ont ete evaluees en utilisant deux sous-echelles du Questionnaire du Comportement du Bebe (abrege IBQ, an anglais, Rothbart, 1981). Les meres et les peres qui evaluerent leur enfant adoptif comme faisant preuve de plus de desarroi envers les restrictions (sur le IBQ) firent etat de moins de plaisir dans les activites routinieres de parentage. Cet effet etait influence par le bonheur conjugal pour les peres. Les meres firent etat de moins de plaisir dans le parentage avec les bebes percus comme etant plus craintifs de temperament (IBQ). La relation bi-directionnelle entre les caracteristiques du temperament et le plaisir du parentage est discutee.
The role of the microenvironment in tumor invasion

Fibroblasts and myofibroblasts in the tumor microenvironment are important players in tumor growth and metastasis because of their unique ability to coordinate events which increase cell proliferation and invasion especially in breast cancer. It has been experimentally shown that fibroblasts play an important role in promoting tumor growth. Our study illustrates a model in which tumor cells are able to communicate with these fibroblasts/myofibroblasts through proteinases for active invasion toward stroma near breast
Assessment and Active Learning Strategies for Introductory Geology Courses

Educational research findings suggest that instructors can foster the growth of thinking skills and promote science literacy by incorporating active learning strategies into the classroom. Active learning occurs when instructors build learner participation into classes. Learning in large, general education Earth Science classes was evaluated using formative assessment exercises conducted by students in groups. Bloom's taxonomy of cognitive development was used as a guide to identify critical thinking skills (comprehension, application, analysis, synthesis, evaluation) that could be linked to specific assessment methods such as conceptests, Venn diagrams, image analysis, concept maps, open-ended questions, and evaluation rubrics. Two instructors conducted a series of analyses on sample classes taught with traditional lecture and inquiry-based learning methods. Qualitative and quantitative analyses show that such methods are preferred by students, improve student retention, produce no decrease in content knowledge, promote deeper understanding of course material, and increase logical thinking skills.
Adenovirus-mediated gene transfer in rat liver of interleukin 4 but not interleukin 10 produces severe acute hepatitis.

Several immune responses are either limited to or concentrated in a given organ. Cytokines produced during ongoing immune responses have organ-localized effects that can be only partially mimicked upon their systemic delivery. Recombinant adenoviruses are efficient vectors to induce transient organ-localized cytokine expression. This allows in vivo analysis of the effects of cytokines produced spatially and temporally in a manner comparable to that observed during immune responses. The authors generated recombinant adenovirus for rat IL-4 (AdIL-4) and IL-10 (AdIL-10) to analyse the in vivo effects of these two important immunoregulatory molecules after gene transfer in the liver. It was first established that AdIL-4 and AdIL-10 were able to direct the production of biologically active cytokines by different rat cell types in vitro. Intraportal injection of doses of up to 10(10) pfu of AdIL-10 or control non-coding recombinant adenovirus were well tolerated, and hepatic histology showed only mild alterations. Conversely, animals receiving more than 2.5 x 10(9) pfu of AdIL-4 showed dose-dependent mortality, with clinical signs of hepatic dysfunction. Liver histology in animals receiving 2.5 x 10(9) pfu of AdIL-4 showed severe acute hepatitis with maximal lesions between day 7 and 14 and almost complete normalization by day 28 after gene transfer. The leukocyte infiltrate was composed primarily of mononuclear cells, but eosinophils and mast cells were significantly increased as compared to control animals. Hepatic function was also altered in animals that received AdIL-4, with kinetics similar to that of histological lesions. Our study describes a model for investigating cytokine function in vivo through liver-localized transgene expression mediated by adenoviral vectors and demonstrates that liver production of IL-4 but not IL-10 results in acute severe hepatitis.
Diagnosis and relation to general health of shoulder disorders presenting to primary care.

OBJECTIVES To prospectively evaluate the incidence, spectrum of disease and relation to general health of shoulder disorders in primary care. METHODS Patients presenting with shoulder pain to two large general practices in the Cambridge area over a 1-month period were invited to participate. After consulting their general practitioner, patients were administered a demographic information questionnaire, a shoulder pain and disability index (SPADI) and a short form 36 (SF-36) health survey. Subsequent review in a clinic held by a rheumatology registrar every 2 weeks was undertaken. RESULTS The sex- and age-standardized incidence of shoulder pain was 9.5 per 1000 (95% confidence interval 7.9 to 11.2 per 1000). Rotator cuff tendinopathy was found in 85%, signs of impingement in 74%, acromioclavicular joint disease in 24%, adhesive capsulitis in 15% and referred pain in 7%. On the SPADI the mean disability subscale score was 45 (95% confidence interval 41 to 50) and the mean pain score was 58 (95% confidence interval 53 to 62) (range 0 to 100). Evaluation of general health status using the SF-36 showed the difference between population norms and those with shoulder pain was significant in six of the eight domains, being especially marked (greater than 20 point reduction) for emotional role, physical function and physical role. CONCLUSION Shoulder pain, most commonly due to rotator cuff tendinopathy, is associated with significantly reduced health when measured by both specific and generic means. Effort towards prevention and early intervention in these complaints is warranted.
On- and Off-Topic Classification and Semantic Annotation of User-Generated Software Requirements

Users prefer natural language software requirements because of their usability and accessibility. When they describe their wishes for software development, they often provide off-topic information. We therefore present an automated approach for identifying and semantically annotating the on-topic parts of the given descriptions. It is designed to support requirement engineers in the requirement elicitation process on detecting and analyzing requirements in user-generated content. Since no lexical resources with domain-specific information about requirements are available, we created a corpus of requirements written in controlled language by instructed users and uncontrolled language by uninstructed users. We annotated these requirements regarding predicate-argument structures, conditions, priorities, motivations and semantic roles and used this information to train classifiers for information extraction purposes. The approach achieves an accuracy of 92% for the on- and off-topic classification task and an F1-measure of 72% for the semantic annotation.
Effects of maternal and embryonic genotype on prenatal survival in two selected mouse lines.

The effect of fetal and maternal genotype on embryo survival was studied in two lines of mice from the same base population: line E, selected for high embryo survival, and line CN-, selected for small litter size. Embryos were collected at 3.5 days postcoitus from normally mated donors of both lines and were transferred to the uteri of 2.5-day pseudopregnant recipients from each line. The number of embryos recovered and the proportion of those recovered that had been fertilized were greater in line E donors than in line CN- donors (P < .05). Development into blastocysts was slower for CN- embryos. The proportion of recipient females that were pregnant was higher for line E than for line CN- after transfer of line E embryos (P < .005). The same trend was observed following transfer of line CN- embryos (P < .10). Embryos of both lines showed greater survival when transferred to line E recipients than when transferred to line CN- recipients (P < .005), and, within line E recipients, E embryos tended to survive better than did CN- embryos (P < .10). The results suggest that although the genotype of the embryo may play a role, the maternal genotype has greater influence on embryo survival in the two lines of mice.
Evaluation of a Mental Health Literacy Training Program for Junior Sporting Clubs

Objective: The aim of this study was to describe and evaluate a training program designed to improve mental health literacy in junior sporting club coaches and leaders. It was anticipated that participants would demonstrate an improvement in knowledge, confidence, and attitudes in relation to mental disorders and help seeking. Methods: A training program called Read the Play was delivered to 40 participants from junior AFL football and netball leagues in the Barwon region of Victoria. The effects of the training were evaluated using pre- and post-questionnaires. Results: The course led to significant improvement in knowledge about mental disorders, increased confidence in helping someone with a mental disorder and more positive attitudes towards people with mental disorders. Conclusions: Training programs delivered within sporting settings may be effective in improving mental health literacy. Future evaluations would benefit from assessing whether these changes are sustained over time and whether trainees subsequently assist young club members to seek appropriate professional help.
Moderate vitamin D deficiency is associated with changes in knee and hip pain in older adults: a 5-year longitudinal study

Background Vitamin D is important for bone, cartilage and muscle function but there are few studies on its association with joint pain. Objective To investigate whether serum vitamin D predicts change in knee and hip pain in older adults. Methods Longitudinal population-based cohort study of randomly selected older adults (n=769) aged 50–80 years (mean 62 years); 50% were male. Serum 25-hydroxyvitamin D (25-OHD) was assessed at baseline by radioimmunoassay, and pain at baseline, 2.6 and/or 5 years using the Western Ontario and McMaster University Osteoarthritis Index (WOMAC) questionnaire. We used linear regression with adjustment for age, sex, body mass index and season, then further adjusted for potential structural mechanisms (radiographic osteoarthritis, bone marrow lesions, chondral defects and muscle strength). Results Mean total knee WOMAC score was 3.2 (range 0–39). 4.2% of participants had moderate vitamin D deficiency at baseline (25-OHD 12.5–25 nmol/l). 25-OHD <25 nmol/l predicted change in knee pain (using total WOMAC score) over 5 years (β=2.41, p=0.002) with a similar effect size for hip pain over 2.4 years (β=2.20, p=0.083). Results were consistent within pain subscales, and the association was independent of demographic, anthropometric and structural covariates. No association was present when 25-OHD was analysed as a continuous measure. Conclusions Moderate vitamin D deficiency independently predicts incident, or worsening of, knee pain over 5 years and, possibly, hip pain over 2.4 years. Therefore correcting moderate vitamin deficiency may attenuate worsening of knee or hip pain in elderly people but giving supplements to those with a higher 25-OHD level is unlikely to be effective.
α‐tocopherol protects against cisplatin‐induced toxicity without interfering with antitumor efficacy

Our aim was 2‐fold: to investigate the role of α‐tocopherol supplementation on the antitumor activity of DDP and to evaluate the effect of α‐tocopherol on the survival and neurotoxicity of DDP‐treated mice. Experiments performed on the M14 human melanoma line demonstrated that α‐tocopherol supplementation did not influence the efficacy of DDP; the inhibition of cell survival and of the in vivo tumor growth after treatment with α‐tocopherol and DDP combination was similar to that observed after DDP alone. Conversely, α‐tocopherol was also able to increase survival of mice treated with a high dose of DDP. While DDP alone produced death in about 70% of mice, the combination reduced deaths to about 30%. Analysis of oxidative stress markers and peroxidative damage in organs indicated that the protective effect of α‐tocopherol was mainly related to its antioxidant activity. A significant increase in the concentration of TBARS and decreased PUFAs and catalase activity were observed after DDP treatment, while with α‐tocopherol the levels of these markers were comparable to those observed in untreated mice. Histologic analysis performed on peripheral nerve revealed that α‐tocopherol also protected mice from severe neurologic damage induced by DDP treatment. In conclusion, our results demonstrate that α‐tocopherol protects against the systemic toxicity and neurotoxicity induced by DDP without interfering with its antitumor activity and suggest that this combination is a promising strategy to improve the therapeutic index of DDP‐based chemotherapy. © 2003 Wiley‐Liss, Inc.
Bonding in GaAs.

Experimental measurements of structure factors in GaAs have been compared with the results of ab initio calculations by the pseudopotential method. We measure the charge in the bond from charge-density maps to be 0.071 electron, in good agreement with theory. The measurements were obtained by an electron-diffraction technique which can be applied to submicron crystals, thus greatly extending the range of materials for which structure factors can be measured, and theoretical calculations tested.
Shivering Thermogenesis in Leg and Breast Muscles of Galliform Chicks and Nestlings of the Domestic Pigeon

We studied the ontogeny of shivering thermogenesis in breast and leg muscles of precocial galliforms (domestic fowl, grey partridge, and Japanese quail) and the altricial domestic pigeon using electromyography (EMG) and indirect calorimetry. Galliforms were able to increase heat production by shivering in leg muscles at the youngest age studied (1–2 d). Pectorals contributed to heat production from days 7–10 onward, but in the partridge and especially in the fowl, shivering by the pectorals was weaker than in the quail. In the pigeon, shivering began in pectorals and legs at 2 and 4 d of age, respectively, and pectorals had clearly the predominant role in thermogenesis. Despite the early beginning of electrical signs of shivering, significant thermogenesis did not appear in the pigeon before the age of 6 d. All galliforms shivered in bursts, like pigeons aged 2–4 d. From the age of 6 d onward, continuous shivering became predominant in the pigeon. In pectorals of 2–6‐d‐old pigeons, shivering did not increase linearly during decreasing ambient temperature, as in other muscles and species, but started abruptly, at full intensity. Furthermore, in 2–4‐d‐old pigeons, cooling induced movement activity in legs. The median frequency of shivering EMGs varied (1) with maturation of the muscle, (2) with size of the adult bird, and (3) between altricials and precocials.
Spinal Cord Stimulation for the Treatment of Chronic Back Pain Patients: 500‐Hz vs. 1000‐Hz Burst Stimulation

Spinal cord stimulation is a commonly used, safe, and effective procedure applied for medically intractable failed back surgery syndrome, as well as other neuropathic pain syndromes. Recently, a novel stimulation paradigm called burst stimulation has been developed that is paresthesia‐free and has a more pronounced suppressive effect on neuropathic pain.
Visual media and the construction of the benign Canadian border on National Geographic's Border Security

Visual media have long been instrumental in the production of international borders as sites of spectacle. Such projects involve careful delineations of who may enter and under what conditions. In Canada, this representation often centres on a dialectical relationship between a welcoming and generous, multicultural nation and a threatening foreign immigrant Other. We adopt a visual content analysis approach to examine Border Security: Canada's Front Line, a documentary series produced for the National Geographic Channel that follows the daily activities of Canadian border security agents. Because this series is sponsored by the Canadian Border Patrol Agency, it provides an ideal case with which to interrogate the State's agenda in representing home, Other and risk. Given previous scholarship on the dialectical representation of Other and Canadian multiculturalism, we expected to find similar juxtapositions on Border Security. Rather, our analysis reveals a carefully managed representation of colour and nation-blindness that supports a construction of Canada in opposition to the United States.