Miracle-dz/UniFAR-FTUs huggingface dataset:
A new approach to unsupervised text summarization

The paper presents a novel approach to unsupervised text summarization. The novelty lies in exploiting the diversity of concepts in text for summarization, which has not received much attention in the summarization literature. A diversity-based approach here is a principled generalization of Maximal Marginal Relevance criterion by Carbonell and Goldstein \cite{carbonell-goldstein98}. We propose, in addition, aninformation-centricapproach to evaluation, where the quality of summaries is judged not in terms of how well they match human-created summaries but in terms of how well they represent their source documents in IR tasks such document retrieval and text categorization. To find the effectiveness of our approach under the proposed evaluation scheme, we set out to examine how a system with the diversity functionality performs against one without, using the BMIR-J2 corpus, a test data developed by a Japanese research consortium. The results demonstrate a clear superiority of a diversity based approach to a non-diversity based approach.
Circulation in the Three‐Chambered Snake Heart

Our knowledge on the physiologic evolution of the cardiovascular system is fragmentary. The reptiles and the snakes in particular represent a stage where our knowledge is especially poor. The present study deals with the circulatory dynamics of the snake heart. It may be suggested that the snake heart effectively prevents extensive mixing of arterial and venous blood. The durations of ventricular filling and contraction differ greatly from that in the mammalian heart.
Optimization of operation rule curves and flushing schedule in a reservoir

Flushing sediment through a reservoir has been practiced successfully and found to be inexpensive in many cases. However, the great amount of water consumed in the flushing operation might affect the water supply. To satisfy the water demand and water consumed in the flushing operation, two models combining the reservoir simulation model and the sediment flushing model are established. In the reservoir simulation model, the genetic algorithm (GA) is used to optimize and determine the flushing operation rule curves. The sediment‐flushing model is developed to estimate the amount of the flushed sediment volume, and the simulated results update the elevation‐storage curve, which can be taken into account in the reservoir simulation model. The models are successfully applied to the Tapu reservoir, which has faced serious sedimentation problems. Based on 36 years historical sequential data, the results show that (i) the simulated flushing operation rule curves model has superior performance, in terms of lower shortage index (SI) and higher flushing efficiency (FE), than that by the original reservoir operation; (ii) the rational and riskless flushing schedule for the Tapu reservoir is suggested to be set within an interval of every 2 or 4 years in the months of May or June. Copyright © 2003 John Wiley & Sons, Ltd.
Curcumin Down-Regulates DNA Methyltransferase 1 and Plays an Anti-Leukemic Role in Acute Myeloid Leukemia

Bioactive components from dietary supplements such as curcumin may represent attractive agents for cancer prevention or treatment. DNA methylation plays a critical role in acute myeloid leukemia (AML) development, and presents an excellent target for treatment of this disease. However, it remains largely unknown how curcumin, a component of the popular Indian spice turmeric, plays a role in DNA hypomethylation to reactivate silenced tumor suppressor genes and to present a potential treatment option for AML. Here we show that curcumin down-regulates DNMT1 expression in AML cell lines, both in vitro and in vivo, and in primary AML cells ex vivo. Mechanistically, curcumin reduced the expression of positive regulators of DNMT1, p65 and Sp1, which correlated with a reduction in binding of these transcription factors to the DNMT1 promoter in AML cell lines. This curcumin-mediated down-regulation of DNMT1 expression was concomitant with p15INK4B tumor suppressor gene reactivation, hypomethylation of the p15INK4B promoter, G1 cell cycle arrest, and induction of tumor cell apoptosis in vitro. In mice implanted with the human AML MV4–11 cell line, administration of curcumin resulted in remarkable suppression of AML tumor growth. Collectively, our data indicate that curcumin shows promise as a potential treatment for AML, and our findings provide a basis for future studies to test the clinical efficacy of curcumin – whether used as a single agent or as an adjuvant – for AML treatment.
Exploration of discrepancy between radar and gauge rainfall estimates driven by wind fields

Due to the fact that weather radar is prone to several sources of errors, it is acknowledged that adjustment against ground observations such as rain gauges is crucial for radar measurement. Spatial matching of precipitation patterns between radar and rain gauge is a significant premise in radar bias corrections. It is a conventional way to construct radar‐gauge pairs based on their vertical locations. However, due to the wind effects, the raindrops observed by the radar do not always fall vertically to the ground, and the raindrops arriving at the ground may not all be caught by the rain gauge. This study proposes a fully formulated scheme to numerically simulate the movement of raindrops in a three‐dimensional wind field in order to adjust the wind‐induced errors. The Brue catchment (135 km2) in Southwest England covering 28 radar pixels and 49 rain gauges is an experimental catchment, where the radar central beam height varies between 500 and 700 m. The 20 typical events (with durations of 6–36 h) are chosen to assess the correlation between hourly radar and gauge rainfall surfaces. It is found that for most events, the improved rates of correlation coefficients are greater than 10%, and nearly half of the events increase by 20%. With the proposed method, except four events, all the event‐averaged correlation values are greater than 0.5. This work is the first study to tackle both wind effects on radar and rain gauges, which could be considered as one of the essential components in processing radar observational data in its hydrometeorological applications.
Exports Versus FDI Revisited: Does Finance Matter?

The crisis on international financial markets that started in 2007 has shown the potential links between the financial sector and the real economy. Exports and foreign direct investment (FDI) have declined, presumably not only because of a lack of demand, but also because of restricted access of firms to external finance. In this paper, we explore the impact of access to external finance on firms' choices to export or to engage in FDI. We simultaneously model a firm's decision to engage in FDI and in exports, and we assess the importance of financial factors for this choice (the extensive margin) as well as for the volume of activities (the intensive margin). We find that financial frictions matter, in particular for the decision to engage internationally.
Removable Visible Watermarking in JPEG Compression Domain

The purpose of this research lies in the development of a user-key dependent removable visible watermarking scheme in JPEG compression domain. The protected images are embedded with the visible watermarks, and further compressed by JPEG compression. The visible watermarks only can be successfully removed by authorized user with the private key. Experimental results show the proposed scheme can recover images to the extent of JPEG-compression qualities.
Enhanced Age Resolution of the Marine Quaternary Record in the Arctic Using Aspartic Acid Racemization Dating of Bivalve Shells

Abstract Aspartic acid (Asp) racemization occurs at a significantly higher rate than isoleucine epimerization and consequently provides better temporal resolution of Arctic marine deposits (from Alaska, Spitsbergen, and Baffin Island). Heating experiments (at 100°C) on the bivalves Mya and Hiatella show the Asp racemization rate decreases with increasing D/L values, as is typical for biogenic carbonates. Based on these experimental racemization rates and rates determined from racemization of samples radiocarbon dated to ca. 10,000–12,000 yr B.P., activation energies for Mya and Hiatella are estimated to be 30.6 and 30.0 kcal/mol, respectively, for Asp racemization, and 29.0 and 29.5 for isoleucine epimerization. Analysis of a time series of Plio–Pleistocene Hiatella from the north coast of Alaska shows that last-interglacial mollusks can be readily distinguished from modern samples by Asp but not by isoleucine. D/L Asp values indicate a younger age for the Fishcreekian transgression than does isoleucine epimerization. For Spitsbergen, D/L Asp shows a slight age difference (ca. 12,000 yr) between two units of the “episode B” interstadial and suggests that the age of these units may be closer to 65,000 than to 80,000 yr B.P., two possible ages suggested by other evidence. The age of the Loks Land Interstadial on Baffin Island is likely to be greater than that indicated by radiocarbon ages. Within deposits from each region, D/L Asp values are less variable among individual shells than isoleucine epimerization values. This may indicate better reliability of Asp for geochronology.
The Impact of Commodity Price Changes on Rural Households: The Case of Coffee in Uganda

Policies and external shocks affecting agriculture, the main source of income for rural households, can be expected to have a significant impact on poverty. The authors study the case of Uganda. Throughout the 1990s, more than 90 percent of its poor lived in rural areas and, during the same period, large international price fluctuations as well as an extensive domestic deregulation affected the coffee sector, its main source of export revenues. Using data from three household surveys covering the 1990s, the authors confirm a strong correlation between changes in coffee prices (in a liberalized market) and poverty reduction. This is highlighted by comparing the performance of different households grouped according to their dependence on coffee farming. Regression analysis (based on pooled data from the three surveys) of consumption expenditure on coffee-related variables, other controls, and time-fixed effects corroborates that the mentioned correlation is not spurious. The authors also find that while both poor and rich farmers enter the coffee sector, the price boom benefits the poorer households relatively more, whereas the liberalization seems to create more opportunities for richer farmers. Finally, notwithstanding the importance of the coffee price boom, the agricultural policy framework and the thorough structural reforms in which the coffee market liberalization was embedded have certainly played a role in triggering overall agricultural growth. These factors appear to matter especially in the second half of the 1990s when prices went down but poverty reduction continued.
The use of artificial nutrition among cancer patients enrolled in palliative home care services

In this study, patients’ views and experiences of using home artificial nutrition, and factors associated with use of home parenteral nutrition (HPN) were investigated. Structured telephone interviews with 620 cancer patients enrolled in 21 palliative home care services were analysed. HPN was more common (11%) than home enteral tube feeding (HETF, 3%). Home artificial nutrition (including HPN and HETF) was usually introduced more than four months before death. Three of four HPN recipients also had oral food intake. HPN use was associated with eating difficulties, nausea/vomiting, and fatigue rather than gastrointestinal problems per se. HETF was generally used for patients with problems related to oesophagus and head and neck tumours. In conclusion the results suggest that, contrary to existing guidelines, HPN is used to supplement oral intake, and not only for patients with a non-functioning gastrointestinal tract.
Modelling climate change impacts on the hydrology of an agricultural watershed in southern Québec

Spring flooding and water availability during the summer are two major concerns in southern Québec. Climate change is expected to further exacerbate shortages of fresh water resources in Québec. Therefore, the impacts of climate change on the hydrology of the Pike River watershed were projected for the 2041–2070 time horizon using a version of the Soil and Water Assessment Tool (SWATqc) adapted to Québec’s agroclimatic conditions. SWATqc was driven by inputs from four climate projections created with the fourth-generation Canadian Regional Climate Model (CRCM4) and the Arpège regional climate model. CRCM4 was driven at the border of its domain by three members of the Canadian Coupled Global Climate Model (CGCM3). The Arpège model, which has a variable grid, is not driven by another model. The gas emissions scenario used to drive climate models was scenario A2. Regional climate data sets were bias-corrected with the delta method prior to being used to drive SWATqc. Projected changes in precipitation and temperatures were analysed for their effects on evapotranspiration, surface and subsurface runoff, and streamflow. Mean annual streamflow was projected to increase between 9 and 19%. All future simulations projected significant increases or decreases in evapotranspiration, surface and subsurface runoff, and streamflow at the monthly time scale. Winter streamflow, for example, increased by 2- to 3-fold compared with the historical values. In addition, future spring floods started earlier and peaked in March instead of April. The four simulations were named ADC, ACU, AFA/AFD, and ARP. All but the ACU simulation projected a decrease in peak flow, while the ADC, AFD and ARP simulations suggested an increase. Although the majority of the simulations pointed to decreases in summer streamflows, the changes were not all significantly different from historical values. Results from this study not only show that climate change has a strong potential to exacerbate seasonal water availability and flooding issues in the watershed, but also provide conservative numbers that could be used in developing improved watershed management plans adapted to future climate change impacts.
Time-series analysis of NDVI from AVHRR data over the Hindu Kush–Himalayan region for the period 1982–2006

The Hindu Kush–Himalayan (HKH) region with its surrounding mountains in central Asia is a region that has been warming at an alarming rate and is sensitive to climate change due to its heterogeneous terrain and high altitude. In a region where research is limited due to the paucity of field-based biophysical observations, analysis of remotely sensed data such as the normalized difference vegetation index (NDVI) can provide invaluable information on spatio-temporal patterns in linkages among land use, climate and vegetative phenological cycles, and trends in vegetative cover. In this study, NDVI data with 8 km spatial resolution for each 15 day composite period from 1982 to 2006 were analysed using a seasonal trend analysis technique, where the first step determines the annual mean and seasonal NDVI patterns across the HKH region. The second step analyses the non-parametric trends in magnitude and timing of the annual mean and seasonal NDVI cycle. The seasonal vegetation cycles were compared for the first and last ten years of the time series and were also analysed across areas undergoing significant change. Results indicated an overall greening trend in NDVI magnitude in most areas, particularly over open shrubland, grassland and cropland. Trends in the annual seasonal timing of NDVI indicated an earlier green-up for most parts of this region. Results also confirmed deforestation trends observed in a few states in northeastern India and Myanmar (Shan state) within the HKH region.
Evaluation of Quality Characteristics of High Nutrient Dense Complementary Food from Mixtures of Malted Quality Protein Maize (Zeamays L.) and Steamed Cowpea (Vigna unguiculata)

Quality Protein Maize is an improved variety of maize which contains higher amount of lysine and tryptophan. Cowpea is an indigenous legume widely consumed in Nigeria. Quality Protein Maize was malted by steeping, germinating, drying and milling while cowpea was dehulled, steamed, dried and milled. The resulting flours were blended to produce complementary food at ratios of 100:0; 70:30 (Quality Protein Maize and Cowpea). The quality characteristics of the blends were assessed by determining the chemical composition, sensory properties, functional and pasting characteristics. The results showed that 30% substitution of cowpea and malting increased the protein level significantly (p>0.05). Potassium, Magnesium and Phosphorus also increased with supplementation. The water absorption capacity, bulk density, peak and final viscosities were significantly (p>0.05) reduced in the malted samples. All the formulated diets were acceptable to the nursing mothers who served as the panelists. The low bulk, water absorption capacity and viscosity of the germinated samples encouraged addition of more solid to the thin gruel produced from it; such addition increased the energy and other nutrients of the gruel as required by infants for growth and development.
Specific Protein Phosphorylation during Stimulation of Amylase Secretion by β‐Agonists or Dibutyryl Adenosine 3′,5′‐Monophosphate in the Rat Parotid Gland

The present study was undertaken in order to examine the possible involvement of protein phosphorylation during β-adrenergic stimulation in the rat parotid gland. Isolated parotid gland slices were stimulated by either isoproterenol or dibutyryl adenosine 3′,5′-monophosphate (Bt2cAMP) in the presence or absence of propranolol. Amylase output was measured as a parameter for the degree of stimulation of secretion. Stimulation of secretion by either isoproterenol or Bt2AMP was associated with phosphorylation of three protein bands as revealed by sodium dodecylsulfate/polyacryla:nide gel electrophoresis and autoradiography. The apparent molecular weights of the three proteins were 35100 (protein I), 25 700 (protein II) and 20400 (protein II). After cell fractionation by differential and gradient centrifugation, protein I was enriched in a light membrane fraction most likely corresponding to the plasma membrane as revealed by marker enzyme analysis. Proteins II and III were recovered in a denser fraction containing mainly mitochondria and rough micrcsomes. The effect of isoproterenol but not that of Bt2cAMP on phosphorylation of all three protein bands was completely abolished by propranolol. The different time course in the stimulation of amylase secretion by isoproterenol and Bt2cAMP respectively was reflected by corresponding differences in the time course of protein phosphorylation.
Cell Tracking via Proposal Generation and Selection

Microscopy imaging plays a vital role in understanding many biological processes in development and disease. The recent advances in automation of microscopes and development of methods and markers for live cell imaging has led to rapid growth in the amount of image data being captured. To efficiently and reliably extract useful insights from these captured sequences, automated cell tracking is essential. This is a challenging problem due to large variation in the appearance and shapes of cells depending on many factors including imaging methodology, biological characteristics of cells, cell matrix composition, labeling methodology, etc. Often cell tracking methods require a sequence-specific segmentation method and manual tuning of many tracking parameters, which limits their applicability to sequences other than those they are designed for. In this paper, we propose 1) a deep learning based cell proposal method, which proposes candidates for cells along with their scores, and 2) a cell tracking method, which links proposals in adjacent frames in a graphical model using edges representing different cellular events and poses joint cell detection and tracking as the selection of a subset of cell and edge proposals. Our method is completely automated and given enough training data can be applied to a wide variety of microscopy sequences. We evaluate our method on multiple fluorescence and phase contrast microscopy sequences containing cells of various shapes and appearances from ISBI cell tracking challenge, and show that our method outperforms existing cell tracking methods. Code is available at: this https URL
Visceral Leishmaniasis and HIV Co-infection in Bihar, India: Long-term Effectiveness and Treatment Outcomes with Liposomal Amphotericin B (AmBisome)

Background Visceral Leishmaniasis (VL; also known as kala-azar) is an ultimately fatal disease endemic in the Indian state of Bihar, while HIV/AIDS is an emerging disease in this region. A 2011 observational cohort study conducted in Bihar involving 55 VL/HIV co-infected patients treated with 20–25 mg/kg intravenous liposomal amphotericin B (AmBisome) estimated an 85.5% probability of survival and a 26.5% probability of VL relapse within 2 years. Here we report the long-term field outcomes of a larger cohort of co-infected patients treated with this regimen between 2007 and 2012. Methods and Principal Findings Intravenous AmBisome (20–25 mg/kg) was administered to 159 VL/HIV co-infected patients (both primary infections and relapses) in four or five doses of 5 mg/kg over 4–10 days. Initial cure of VL at discharge was defined as improved symptoms, cessation of fever, improvement of appetite and recession of spleen enlargement. Test of cure was not routinely performed. Antiretroviral treatment (ART) was initiated in 23 (14.5%), 39 (24.5%) and 61 (38.4%) before, during and after admission respectively. Initial cure was achieved in all discharged patients. A total of 36 patients died during follow-up, including six who died shortly after admission. Death occurred at a median of 11 weeks (IQR 4–51) after starting VL treatment. Estimated mortality risk was 14.3% at six months, 22.4% at two years and 29.7% at four years after treatment. Among the 153 patients discharged from the hospital, 26 cases of VL relapse were diagnosed during follow-up, occurring at a median of 10 months (IQR 7–14) after discharge. After accounting for competing risks, the estimated risk of relapse was 16.1% at one year, 20.4% at two years and 25.9% at four years. Low hemoglobin level and concurrent infection with tuberculosis were independent risk factors for mortality, while ART initiated shortly after admission for VL treatment was associated with a 64–66% reduced risk of mortality and 75% reduced risk of relapse. Significance This is the largest cohort of HIV-VL co-infected patients reported from the Indian subcontinent. Even after initial cure following treatment with AmBisome, these patients appear to have much higher rates of VL relapse and mortality than patients not known to be HIV-positive, although relapse rates appear to stabilize after 2 years. These results extend the earlier findings that co-infected patients are at increased risk of death and require a multidisciplinary approach for long-term management.
Is the neonatal creatine phosphokinase level a reliable marker for fetal hypoxia?

The creatine phosphokinase (CPK) level is believed to increase in neonatal peripheral blood after tissue damage, including damage from perinatal hypoxia. However, it is not clear whether it is truly a reliable marker for fetal hypoxia. We investigated the chronological changes in neonatal CPK and the reliability of CPK as a marker for fetal hypoxia.