Miracle-dz/UniFAR-FTUs huggingface dataset:
The Learning and Prediction of Application-Level Traffic Data in Cellular Networks

Traffic learning and prediction is at the heart of the evaluation of the performance of telecommunications networks and attracts a lot of attention in wired broadband networks. Now, benefiting from the big data in cellular networks, it becomes possible to make the analyses one step further into the application level. In this paper, we first collect a significant amount of application-level traffic data from cellular network operators. Afterward, with the aid of the traffic “big data,” we make a comprehensive study over the modeling and prediction framework of cellular network traffic. Our results solidly demonstrate that there universally exist some traffic statistical modeling characteristics at a service or application granularity, including $\alpha$ -stable modeled property in the temporal domain and the sparsity in the spatial domain. But, different service types of applications possess distinct parameter settings. Furthermore, we propose a new traffic prediction framework to encompass and explore these aforementioned characteristics and then develop a dictionary learning-based alternating direction method to solve it. Finally, we examine the effectiveness and robustness of the proposed framework for different types of application-level traffic. Our simulation results prove that the proposed framework could offer a unified solution for application-level traffic learning and prediction and significantly contribute to solve the modeling and forecasting issues.
The Lifting Scheme: A Custom - Design Construction of Biorthogonal Wavelets "Industrial Mathematics

A control circuit for a fuel ignition system of the direct ignition type for providing an interlock on start-up to prevent the energization of a fuel supply valve of the system under certain failure conditions includes an interlock relay which is energized, after a predetermined delay, over normally closed contacts of a flame relay to control a timing network to cause a flame sensing circuit to enable the flame relay to energize the valve during a trial for ignition interval defined by the timing network, the flame sensing circuit maintaining the flame relay, and thus the valve, energized when a flame is provided during the trial for ignition interval, the energization of the valve and the interlock relay being prevented if the normally closed contacts of the flame relay are open on start-up, and the delayed operation of the interlock relay preventing lockout of the system following momentary loss of power.
A mm-Wave High Speed Wireless LAN for Mobile Computing-Architecture and Prototype Modem / Codec Implementation

Current wireless LANs that are small enough for portable computing devices have transmission rates up to a few Mbit/s, at the lower end of that obtained in IEEE 802compliant wired LANs. These LANs can provide a useful service when the application demands and number of users are kept low. Much higher performance, from several 10’s of Mbit/s to over 100 Mbit/s, is needed to accommodate more users and multimedia traffic.
Robust Disambiguation of Named Entities in Text

Disambiguating named entities in natural-language text maps mentions of ambiguous names onto canonical entities like people or places, registered in a knowledge base such as DBpedia or YAGO. This paper presents a robust method for collective disambiguation, by harnessing context from knowledge bases and using a new form of coherence graph. It unifies prior approaches into a comprehensive framework that combines three measures: the prior probability of an entity being mentioned, the similarity between the contexts of a mention and a candidate entity, as well as the coherence among candidate entities for all mentions together. The method builds a weighted graph of mentions and candidate entities, and computes a dense subgraph that approximates the best joint mention-entity mapping. Experiments show that the new method significantly outperforms prior methods in terms of accuracy, with robust behavior across a variety of inputs.
Clinical and pathological evaluation of hypertensive emergency-related nephropathy.

OBJECTIVE The prognosis of patients with hypertensive emergencies has recently improved dramatically owing to the development of effective antihypertensive therapy. We examined the histological and clinical features of patients with hypertensive emergency-related nephropathy. METHODS Twelve patients (11 men and one woman) were diagnosed as having hypertensive emergencies with acute renal failure according to the Joint National Committee-7 classification of blood pressure for adults and underwent renal biopsies at our hospital between 1995 and 2008. These patients were enrolled in this retrospective study. RESULTS The age of the subjects was 40.1±9.8 years. At presentation, the mean systolic/diastolic blood pressure was 232±32/146±12 mmHg and none of the patients were being treated with antihypertensive drugs, although 10 patients had histories of hypertension. The mean serum creatinine level was 6.1±4.7 mg/dL. All 12 patients showed left ventricular hypertrophy on echocardiography. On light microscopy of the renal biopsy specimens, all 12 patients showed onion skin patterns of the arterioles; however, no fibrinoid necrosis of the small arteries was found. Electron microscopy revealed electron-lucent widening of the subendothelial zone of the glomerular capillary walls in seven patients. One of the 12 patients did not respond to medical therapy and required regular dialysis. The other 11 patients responded to treatment. CONCLUSION An onion skin pattern of the arterioles is the most frequent histological finding in patients with hypertensive emergency-related nephropathy. Long-standing hypertension might contribute to this arteriolar change, since left ventricular hypertrophy was also seen in these patients. With strict control of hypertension using antihypertensive medications, the prognosis of patients with hypertensive emergency-related nephropathy can be improved.
A Digital Predictive Current-Mode Controller for a Single-Phase High-Frequency Transformer-Isolated Dual-Active Bridge DC-to-DC Converter

This paper presents predictive current-mode control for a single-phase high-frequency transformer-isolated dual-active bridge dc-to-dc converter. The predictive control algorithm increases the bandwidth of the current loop of the converter which enables tracking of the current reference within one switching cycle. The paper further demonstrates that the application of the predictive control algorithm can remove transient dc offset from the current in high-frequency isolation transformer within one switching cycle. Direct control of the converter current protects the transformer from saturation even at transient conditions. The control algorithm has been implemented on an experimental setup and transient tests have been performed to validate controller performance. Since the predictive control algorithm is dependent on the measured value of the leakage inductance of the transformer, a compensator has been implemented to improve the parameter insensitivity of the proposed controller.
Effects of the Proton Pump Inhibitor Lansoprazole on the Pharmacokinetics and Pharmacodynamics of Prasugrel and Clopidogrel

Prasugrel and clopidogrel, thienopyridine prodrugs, are each metabolized to an active metabolite that inhibits the platelet P2Y12 ADP receptor. In this open‐label, 4‐period crossover study, the effects of the proton pump inhibitor lansoprazole on the pharmacokinetics and pharmacodynamics of prasugrel and clopidogrel were assessed in healthy subjects given single doses of prasugrel 60 mg and clopidogrel 300 mg with and without concurrent lansoprazole 30 mg qd. Cmax and AUC0‐tlast of prasugrel's active metabolite, R‐138727, and clopidogrel's inactive carboxylic acid metabolite, SR26334, were assessed. Inhibition of platelet aggregation (IPA) was measured by turbidimetric aggregometry 4 to 24 hours after each treatment. Lansoprazole (1) decreased R‐138727 AUC0‐tlast and Cmax by 13% and 29%, respectively, but did not affect IPA after the prasugrel dose, and (2) did not affect SR62334 exposure but tended to lower IPA after a clopidogrel dose. A retrospective tertile analysis showed in subjects with high IPA after a clopidogrel dose alone that lansoprazole decreased IPA, whereas IPA was unaffected in these same subjects after a prasugrel dose. The overall data suggest that a prasugrel dose adjustment is not likely warranted in an individual taking prasugrel with a proton pump inhibitor such as lansoprazole.
Theory of Monte Carlo sampling-based Alopex algorithms for neural networks

We propose two novel Monte Carlo sampling-based Alopex (ALgorithm Of Pattern EXtraction) algorithms for training neural networks. The proposed algorithms naturally combine the sequential Monte Carlo estimation and Alopex-like procedure for gradient-free optimization, and the learning proceeds within the recursive Bayesian estimation framework. Experimental results on various problems show encouraging convergence results.
Effect of early eradication on Helicobacter pylori‐related gastric carcinogenesis in Mongolian gerbils

Helicobacter pylori (Hp) infection and gastric carcinogenesis are known to have a close relationship, but the effect of eradication of Hp on Hp‐related gastric carcinogenesis has not been fully studied experimentally. To evaluate the effect of eradication in gastric carcinogenesis, an experimental model with eradication in the early, middle or late period was studied using Hp‐infected and N‐methyl‐N‐nitrosourea (MNU)‐treated Mongolian gerbils. The animals were divided into seven groups: group A (MNU+Hp+ eradication at 15 w), group B (MNU+Hp+eradication at 35 w), group C (MNU+Hp+eradication at 55 w), group D (MNU+Hp), group E (MNU), group F (Hp) and group G (control). The tumor incidences at week 75 in the early (group A), middle (group B) and late (group C) eradicated groups were 6.7%, 27.3% and 38.2%, respectively. The incidence of 56.3% in the non‐eradicated group was the highest (group D). Incidences in group E, group F and group G were 6.3%, 0.0% and 0.0%, respectively. The tumor incidences were related to the period of inflammatory status induced by Hp infection. Hp infection strongly enhanced gastric carcinogenesis initiated with a chemical carcinogen, and following eradication at an early period this enhancing effect was effectively reduced. Eradication at an early stage of inflammation might be effective in preventing Hp‐related gastric carcinogenesis. (Cancer Sci 2003; 94: 235–239)
Toxicoinfectious Botulism in Commercial Caponized Chickens

Abstract During the summer of 2003, two flocks of commercial broiler chickens experienced unusually high death losses following caponizing at 3 wk of age and again between 8 and 14 wk of age. In September, fifteen 11-wk-old live capons were submitted to the Iowa State University Veterinary Diagnostic Laboratory for assistance. In both flocks, the second episode of elevated mortality was associated with incoordination, flaccid paralysis of leg, wing, and neck muscles, a recumbent body posture characterized by neck extension, and diarrhea. No macroscopic or microscopic lesions were detected in affected chickens. Hearts containing clotted blood and ceca were submitted to the National Wildlife Health Center in Madison, WI. Type C botulinum toxin was identified in heart blood and ceca by mouse bioassay tests. Enzyme-linked immunosorbent assay tests on heart blood samples were also positive for type C botulinum toxin. Clostridium botulinum was isolated from the ceca and genes encoding type C botulinum toxin were detected in cecal contents by a polymerase chain reaction test. Chickens are less susceptible to botulism as they age, and this disease has not previously been documented in broilers as old as 14 wk of age. Wound contamination by spores of C. botulinum may have contributed to the unusually high death losses following caponizing.
Cost-Sharing: Patient Knowledge and Effects on Seeking Emergency Department Care

BackgroundThe use of cost-sharing to control healthcare expenditures is increasing, but there is scant information about patients’ knowledge of cost-sharing or its influence on behavior. ObjectiveThe objective of this study was to evaluate what patients know about their individual levels of cost-sharing and how it influences decisions to seek care. Study DesignWe conducted a cross-sectional telephone survey with a 69% response rate. SubjectsWe studied a stratified random sample of 695 adult patients in an integrated delivery system: 266 subjects ≥65 years, 218 low-income subjects, and 211 subjects from the overall membership. MeasuresWe used perceived and actual levels of copayments for emergency department (ED) visits, office visits, and prescription drugs; and self-reports of copayment-related behavior changes. ResultsOne third of subjects correctly reported their ED copayment, whereas three fourths correctly reported their prescription drug and office visit copayments. Over half of the subjects (57%) underestimated their ED copayment by $20 or more. Among patients who reported having any copayment, 11% described changing their behavior because of the copayment, ie, delayed or avoided emergency care. The perceived copayment level was strongly associated with behavior change (odds ratio, 3.9). Other significant factors included having more ED visits in the past 12 months and having a low health status. ConclusionsPatients have less knowledge of their ED cost-sharing levels than for other services. The perceived copayment amount was strongly associated with avoidance of or delays in emergency care. Further research is needed to determine whether these responses reflect greater efficiency or harmful decisions.
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approved: Redacted for Privacy ()James D. White Pillaromycin A, an antibiotic natural product, displays antitumor activity with relatively low cardiotoxicity compared to the structurally similar anthracyclines. In this study, asymmetric approaches toward the synthesis of the tetracyclic aglycone are presented. A convergent route was developed around a C ring annulation strategy, whereby the anion of ethyl 6-methoxy-2-methylbenzoate (34) was condensed with an appropriate s-alkoxy-a,3-unsaturated ketone of the AB ring synthon 88A. An approach to an asymmetric AB ring synthon was initiated from D-glucal 49 and carried through the critical intramolecular DielsAlder reaction via the (7S,8R)-7-acryloxy-8-acetoxy-2-t-butyldimethylsiloxy-3,5-nonadiene (59). Three Diels-Alder products were obtained in a ratio of 2.5:2.5:1, in 85% yield. The two major isomers were believed to each possess the opposite absolute configuration about the allylic ring fusion C(4a) to that of pillaromycinone. A parallel sequence to the AB ring system of pillaromycinone was achieved from L-rhamnal. Glycolization and protection of the Diels-Alder adducts afforded isomers Si and 83 confirming the correct absolute configuration at C(4a) in the major Diels-Alder products. Conversion to the B ring 1,3-dione, followed by 0-alkylation, afforded the asymmetric AB ring synthon 88A. A convergent assembly of the tetracyclic nucleus of pillaromycinone was accomplished via the condensation of 34 and 88A. Concomitant C ring annulation and aromatization yielded 32% of the (2R,33,4R,4aS)-3,4-dihydroxy-(l,2,3,4,4a,12a)-hexahydro-ll-hydroxy-10methoxy-2-(1-t-butyldimethylsiloxyethyl)-12(5H)-naphthacenone ketal (89). Approaches toward the Asymmetric Synthesis of Pillaromycin A. by
Computed Tomography-Based Tumor Volume in Non-Hodgkin Lymphoma: Clinical Correlation and Comparison With Magnetic Resonance Imaging

Objectives: To evaluate the prognostic significance of tumor volume in computed tomographic (CT) images of non-Hodgkin lymphoma patients. To compare CT volumes with those measured by magnetic resonance imaging (MRI). Methods: Twenty-five patients with B cell-type non-Hodgkin lymphoma (16 men, 9 women, age range, 48-77 years) were imaged with CT at 5 time points. The volumes and volume reductions were associated with clinical characteristics and treatment outcome. The CT-derived tumor volumes were correlated with MRI volumes derived earlier for the same patients. Results: Good agreement was found between 1-dimensional (1D), 2D, and 3D analyses. The CT-derived median tumor volumes were 306 cm3, 174 cm3, 75 cm3, 28 cm3, and 15 cm3 at the 5 time points. These volumes were found to associate, for example, with mortality and tumor malignancy. The CT-based tumor volumes showed good correlation with MRI. Conclusions: Tumor volume quantification is a powerful tool that associates with clinical characteristics and treatment outcome.
Some ( Known ) Facts on Multicarrier Communication

It is widely known and accepted that multicarrier communica tion is effective in frequency selective channels if resour ce allocation strategies are used, namely per-subcarrier ada ptive modulation and coding. We discuss its efficiency for un iform resource allocation in terms of fundamental information-theoretic measures. These results are relevant to broadcast systems a nd, more generally, systems which cannot rely on a feedback channel.
Prevalence of Mycobacterium tuberculosis infection among injection drug users in Toronto.

BACKGROUND Injection drug users are at increased risk of Mycobacterium tuberculosis infection and active tuberculosis (TB). The primary objective of this study was to determine the prevalence of M. tuberculosis infection among injection drug users in Toronto, as indicated by a positive tuberculin skin test result. An additional objective was to identify predictors of a positive skin test result in this population. METHODS A cross-sectional study was carried out involving self-selected injection drug users in the city of Toronto. A total of 171 participants were recruited through a downtown Toronto needle-exchange program from June 1 to Oct. 31, 1996. RESULTS Of 167 subjects tested, 155 (92.8%) returned for interpretation of their skin test result within the designated timeframe (48 to 72 hours). Using a 5-mm cut-off, the prevalence rate of positive tuberculin skin test results was 31.0% (95% confidence interval 23.8% to 38.9%). Birth outside of Canada and increasing age were both predictive of a positive result. INTERPRETATION There is a high burden of M. tuberculosis infection in this population of injection drug users. The compliance observed with returning for interpretation of skin test results indicates that successful TB screening is possible among injection drug users.
Colour and stellar population gradients in galaxies: correlation with mass

We analyse the colour gradients (CGs) of ∼50 000 nearby Sloan Digital Sky Survey galaxies estimated by their photometrical parameters (Sersic index, total magnitude and effective radius). From synthetic spectral models based on a simplified star formation recipe, we derive the mean spectral properties and explain the observed radial trends of the colour as gradients of the stellar population age and metallicity. CGs have been correlated with colour, luminosity, size, velocity dispersion and stellar mass. Distinct behaviours are found for early- and late-type galaxies (ETGs and LTGs), pointing to slightly different physical processes at work in different morphological types and at different mass scales. In particular, the most massive ETGs (M * ≳ 10 11 M ⊙ ) have shallow (even flat) CGs in correspondence of shallow (negative) metallicity gradients. In the stellar mass range (10 10.3 -10 10.5 ) ≲ M * ≲ 10 11 M ⊙ , the metallicity gradients reach their minimum of ∼ - 0.5 dex -1 . At M * ∼ 10 10.3 - 10 10.5 M ⊙ , colour and metallicity gradient slopes suddenly change. They turn out to anticorrelate with the mass, becoming highly positive at the very low masses, the transition from negative to positive occurring at M * ∼ 10 9-9.5 M ⊙ . These correlations are mirrored by similar trends of CGs with the effective radius and the velocity dispersion. We have also found that age gradients anticorrelate with metallicity gradients, as predicted by hierarchical cosmological simulations for ETGs. On the other side, LTGs have colour and metallicity gradients which systematically decrease with mass (and are always more negative than in ETGs), consistently with the expectation from gas infall and supernovae feedback scenarios. Metallicity is found to be the main driver of the trend of CGs, especially for LTGs, but age gradients are not negligible and seem to play a significant role too. Owing to the large data set, we have been able to highlight that older galaxies have systematically shallower age and metallicity gradients than younger ones. The emerging picture is qualitatively consistent with the predictions from hydrodynamical and chemodynamical simulations. In particular, our results for high-mass galaxies are in perfect agreement with predictions based on the merging scenario, while the evolution of LTGs and younger and less massive ETGs seems to be mainly driven by infall and supernovae feedback.
Genetic Polymorphisms of the Main Transcription Factors for Adiponectin Gene Promoter in Regulation of Adiponectin Levels: Association Analysis in Three European Cohorts

Adiponectin serum concentrations are an important biomarker in cardiovascular epidemiology with heritability etimates of 30–70%. However, known genetic variants in the adiponectin gene locus (ADIPOQ) account for only 2%–8% of its variance. As transcription factors are thought to play an under-acknowledged role in carrying functional variants, we hypothesized that genetic polymorphisms in genes coding for the main transcription factors for the ADIPOQ promoter influence adiponectin levels. Single nucleotide polymorphisms (SNPs) at these genes were selected based on the haplotype block structure and previously published evidence to be associated with adiponectin levels. We performed association analyses of the 24 selected SNPs at forkhead box O1 (FOXO1), sterol-regulatory-element-binding transcription factor 1 (SREBF1), sirtuin 1 (SIRT1), peroxisome-proliferator-activated receptor gamma (PPARG) and transcription factor activating enhancer binding protein 2 beta (TFAP2B) gene loci with adiponectin levels in three different European cohorts: SAPHIR (n = 1742), KORA F3 (n = 1636) and CoLaus (n = 5355). In each study population, the association of SNPs with adiponectin levels on log-scale was tested using linear regression adjusted for age, sex and body mass index, applying both an additive and a recessive genetic model. A pooled effect size was obtained by meta-analysis assuming a fixed effects model. We applied a significance threshold of 0.0033 accounting for the multiple testing situation. A significant association was only found for variants within SREBF1 applying an additive genetic model (smallest p-value for rs1889018 on log(adiponectin) = 0.002, β on original scale = −0.217 µg/ml), explaining ∼0.4% of variation of adiponectin levels. Recessive genetic models or haplotype analyses of the FOXO1, SREBF1, SIRT1, TFAPB2B genes or sex-stratified analyses did not reveal additional information on the regulation of adiponectin levels. The role of genetic variations at the SREBF1 gene in regulating adiponectin needs further investigation by functional studies.