Miracle-dz/UniFAR-FTUs huggingface dataset:
Global Capitalism Meets National Spirit

In this article, the authors explore media coverage of a recent acquisition across national borders. Their starting point is that the media represent a key arena of “discursive strategizing” for actors such as corporate managers. They illustrate and specify how global capitalism, as discourse relying on economic and financial rationale and exemplified here by the acquiring firm’s attempts to expand, meets national spirit, exemplified here by the complexity in selling the acquisition target to foreigners. The main contribution of this study lies in identifying how key actors draw on and mobilize rationalistic and nationalistic discourses in public discussion. The analysis illustrates that the same actors can draw on different—even contradictory—discourses at different points in time. Furthermore, different actors—even with opposing objectives—may draw on the same discourse in legitimizing their positions and pursuing specific ends.
Tracing the Impact of Bank Liquidity Shocks: Evidence from an Emerging Market

Do liquidity shocks matter? While even a simple `yes' or `no' presents identification challenges, going beyond this entails tracing how such shocks to lenders are passed on to borrowers, and whether borrowers can in turn cushion these shocks through the credit market. This paper does so by using data that follows all loans made by lenders to borrowing firms in Pakistan, and exploiting cross-bank variation in liquidity shocks induced by the unanticipated nuclear tests in 1998. We isolate the causal impact of the bank lending channel by showing that for the same firm borrowing from two different banks, its loan from the bank experiencing a 1% larger decline in liquidity drops by an additional 0.6%. The liquidity shock also lowers the probability of continued lending to old clients and extending credit to new ones. Although this lending channel affects all firms significantly, large firms and those with strong business and political ties completely compensate the effect by borrowing more from more liquid banks - both through existing and new banking relationships. In contrast, small unconnected firms are entirely unable to hedge and face large drops in overall borrowing and increased financial distress. The liquidity shocks thus have large distributional consequences.
Molecular Ecological Insights into Neotropical Bird–Tick Interactions

In the tropics, ticks parasitize many classes of vertebrate hosts. However, because many tropical tick species are only identifiable in the adult stage, and these adults usually parasitize mammals, most attention on the ecology of tick-host interactions has focused on mammalian hosts. In contrast, immature Neotropical ticks are often found on wild birds, yet difficulties in identifying immatures hinder studies of birds’ role in tropical tick ecology and tick-borne disease transmission. In Panama, we found immature ticks on 227 out of 3,498 individually–sampled birds representing 93 host species (24% of the bird species sampled, and 13% of the Panamanian land bird fauna). Tick parasitism rates did not vary with rainfall or temperature, but did vary significantly with several host ecological traits. Likewise, Neotropical–Nearctic migratory birds were significantly less likely to be infested than resident species. Using a molecular library developed from morphologically–identified adult ticks specifically for this study, we identified eleven tick species parasitizing birds, indicating that a substantial portion of the Panamanian avian species pool is parasitized by a diversity of tick species. Tick species that most commonly parasitized birds had the widest diversity of avian hosts, suggesting that immature tick species are opportunistic bird parasites. Although certain avian ecological traits are positively associated with parasitism, we found no evidence that individual tick species show specificity to particular avian host ecological traits. Finally, our data suggest that the four principal vectors of Rocky Mountain Spotted Fever in the Neotropics rarely, if ever, parasitize Panamanian birds. However, other tick species that harbor newly–discovered rickettsial parasites of unknown pathogenicity are frequently found on these birds. Given our discovery of broad interaction between Panamanian tick and avian biodiversity, future work on tick ecology and the dynamics of emerging tropical tick-borne pathogens should explicitly consider wild bird as hosts.
The randomised prospective comparative study to see the duration of analgesia following intravenous or rectal acetaminophen after adenotonsillectomy in children

Background: The greatest advance in pediatric pain medicine is the recognition that untreated pain is a significant cause of morbidity and even mortality after surgical trauma. Author compared the analgesic efficacy and duration of analgesia of rectal acetaminophen and I.V. acetaminophen.Methods: A total of 80 children in the age group of 2-5 years were randomly selected and divided into 2 groups. Group I received 15 mg/kg I.V. paracetamol and group II received 40 mg/kg rectal acetaminophen. Post-operative pain scores were measured using Face, Legs, Activity, Cry and Consolability scale and duration of analgesia were recorded and compared.Results: The pain scores in group I was lower immediately after extubation and at 30 minutes post extubations but at one, two and four hours the pains score were comparable in both the groups. At 6 hours, the pain score was significantly more in I.V. group and also the duration of analgesia was 9-10 hours in rectal acetaminophen group where as in I.V. group, it was 5-6 hours.Conclusions: Rectal acetaminophen 40 mg/kg produces prolonged analgesia as compared to I.V. paracetamol 15 mg/kg and also is more convenient and cost effective and is devoid of side effects of I.V. cannulation.
Italian nationwide survey of pharmacologic treatments in diverticular disease: Results from the REMAD registry

Background Although diverticular disease is a common condition, its effective treatment is challenging in clinical practice. Objective The objective of this article is to assess pharmacological management in different clinical settings of diverticular disease and factors associated with treatment using the Italian registry Registro Malattia Diverticolare (REMAD). Methods At study enrolment, patients were categorised into subgroups: diverticulosis, symptomatic uncomplicated diverticular disease and previous diverticulitis. We registered demographic, clinical and lifestyle factors, quality of life and the use of treatments for diverticular disease in the last year. Logistic regression analysis assessed the association between clinical factors and treatment consumption. Results A total of 500 of the 1206 individuals included had had at least one treatment for diverticular disease in the last year: 23.6% (166/702) of patients with diverticulosis, 55.9% (165/295) of patients with symptomatic diverticular disease, and 80.9% (169/209) of patients with previous diverticulitis (p < 0.001). In multivariate analysis, the following factors were significantly associated with treatment use: female gender, family history of colonic diverticula, organic digestive comorbidity and impaired physical quality of life components. Conclusion Individuals with diverticular disease take medications based on the different clinical settings of disease. We identified different features associated with treatment use in the distinct clinical entities of diverticular disease. ClinicalTrial.gov Identifier: NCT03325829.
Development and Validation of CorynebacteriumDNA Microarrays

ABSTRACT We have developed DNA microarray techniques for studyingCorynebacterium glutamicum. A set of 52 C. glutamicum genes encoding enzymes from primary metabolism was amplified by PCR and printed in triplicate onto glass slides. Total RNA was extracted from cells harvested during the exponential-growth and lysine production phases of a C. glutamicum fermentation. Fluorescently labeled cDNAs were prepared by reverse transcription using random hexamer primers and hybridized to the microarrays. To establish a set of benchmark metrics for this technique, we compared the variability between replicate spots on the same slide, between slides hybridized with cDNAs from the same labeling reaction, and between slides hybridized with cDNAs prepared in separate labeling reactions. We found that the results were both robust and statistically reproducible. Spot-to-spot variability was 3.8% between replicate spots on a given slide, 5.0% between spots on separate slides (though hybridized with identical, labeled cDNA), and 8.1% between spots from separate slides hybridized with samples from separate reverse transcription reactions yielding an average spot to spot variability of 7.1% across all conditions. Furthermore, when we examined the changes in gene expression that occurred between the two phases of the fermentation, we found that results for the majority of the genes agreed with observations made using other methods. These procedures will be a valuable addition to the metabolic engineering toolbox for the improvement of C. glutamicum amino acid-producing strains.
Separating voices in MIDI

This paper presents an algorithm for converting midi events into logical voices. The algorithm is fundamentally based on the pitch proximity principle. New heuristics are introduced and evaluated in order to handle unsolved situations. The algorithm is tested on ground truth data: inventions and fugues by J. S. Bach. Due to its left to right processing it also runs on real time input.
Funding, disease area, and internal validity of hepatobiliary randomized clinical trials

OBJECTIVE:The aim of this study was to assess whether funding and the disease area are related to the internal validity of hepatobiliary randomized clinical trials.METHODS:We gathered data on funding, disease area, methodological quality (randomization and double blinding), and sample size from 616 hepatobiliary randomized clinical trials published from 1985 to 1996 in 12 MEDLINE indexed journals.RESULTS:The internal validity (methodological quality and sample size) of trials funded by profit or nonprofit organizations was not significantly different. Compared with these trials, trials without funding were significantly less likely to report adequate generation of the allocation sequence (55% vs 41%, p = 0.001) and to be double blind (42% vs 25%, p < 0.001), but the proportion with adequate allocation concealment and the sample size were not significantly different. The trials covered 12 disease areas. The proportion of funded trials did not differ significantly in different disease areas. The disease area was significantly associated with the proportion of trials with adequate generation of the allocation sequence (p < 0.001), allocation concealment (p = 0.003), and double blinding (p < 0.001) as well as the sample size (p < 0.001). This association was not explained by the proportion of trials with funding.CONCLUSIONS:External funding was significantly associated with adequate methodological quality, but not with the sample size. Irrespective of funding, the disease area was significantly associated with the methodological quality and sample size. Accordingly, external funding and the disease area are significant predictors of the internal validity of hepatobiliary randomized clinical trials.
Effects of Hovenia dulcis Thunb. extract and methyl vanillate on atopic dermatitis‐like skin lesions and TNF‐α/IFN‐γ‐induced chemokines production in HaCaT cells

Here, we hypothesized that Hovenia dulcis branch extract (HDB) and its active constituents ameliorates 2,4‐dinitrochlorobenzene‐induced atopic dermatitis (AD)‐like skin lesions by modulating the T helper Th1/Th2 balance in NC/Nga mice and TNF‐α‐ and IFN‐γ‐induced production of thymus and activation‐regulated chemokine (TARC) and macrophage‐derived chemokine (MDC) in HaCaT cells.
Transcriptome Sequencing Reveals Differences between Primary and Secondary Hair Follicle-derived Dermal Papilla Cells of the Cashmere Goat (Capra hircus)

The dermal papilla is thought to establish the character and control the size of hair follicles. Inner Mongolia Cashmere goats (Capra hircus) have a double coat comprising the primary and secondary hair follicles, which have dramatically different sizes and textures. The Cashmere goat is rapidly becoming a potent model for hair follicle morphogenesis research. In this study, we established two dermal papilla cell lines during the anagen phase of the hair growth cycle from the primary and secondary hair follicles and clarified the similarities and differences in their morphology and growth characteristics. High-throughput transcriptome sequencing was used to identify gene expression differences between the two dermal papilla cell lines. Many of the differentially expressed genes are involved in vascularization, ECM-receptor interaction and Wnt/β-catenin/Lef1 signaling pathways, which intimately associated with hair follicle morphogenesis. These findings provide valuable information for research on postnatal morphogenesis of hair follicles.
Angle imaging: Advances and challenges

Primary angle closure glaucoma (PACG) is a major form of glaucoma in large populous countries in East and South Asia. The high visual morbidity from PACG is related to the destructive nature of the asymptomatic form of the disease. Early detection of anatomically narrow angles is important and the subsequent prevention of visual loss from PACG depends on an accurate assessment of the anterior chamber angle (ACA). This review paper discusses the advantages and limitations of newer ACA imaging technologies, namely ultrasound biomicroscopy, Scheimpflug photography, anterior segment optical coherence tomography and EyeCam, highlighting the current clinical evidence comparing these devices with each other and with clinical dynamic indentation gonioscopy, the current reference standard.
Consumer video understanding: a benchmark database and an evaluation of human and machine performance

Recognizing visual content in unconstrained videos has become a very important problem for many applications. Existing corpora for video analysis lack scale and/or content diversity, and thus limited the needed progress in this critical area. In this paper, we describe and release a new database called CCV, containing 9,317 web videos over 20 semantic categories, including events like "baseball" and "parade", scenes like "beach", and objects like "cat". The database was collected with extra care to ensure relevance to consumer interest and originality of video content without post-editing. Such videos typically have very little textual annotation and thus can benefit from the development of automatic content analysis techniques. We used Amazon MTurk platform to perform manual annotation, and studied the behaviors and performance of human annotators on MTurk. We also compared the abilities in understanding consumer video content by humans and machines. For the latter, we implemented automatic classifiers using state-of-the-art multi-modal approach that achieved top performance in recent TRECVID multimedia event detection task. Results confirmed classifiers fusing audio and video features significantly outperform single-modality solutions. We also found that humans are much better at understanding categories of nonrigid objects such as "cat", while current automatic techniques are relatively close to humans in recognizing categories that have distinctive background scenes or audio patterns.
Overuse Tendinosis, Not Tendinitis

IN BRIEF: Overuse tendinopathies are common in primary care. Numerous investigators worldwide have shown that the pathology underlying these conditions is tendinosis or collagen degeneration. This applies equally in the Achilles, patellar, medial and lateral elbow, and rotator cuff tendons. If physicians acknowledge that overuse tendinopathies are due to tendinosis, as distinct from tendinitis, they must modify patient management in at least eight areas. These include adaptation of advice given when counseling, interaction with the physical therapist and athletic trainer, interpretation of imaging, choice of conservative management, and consideration of whether surgery is an option.
Viral load and duration of BK polyomavirus viraemia determine renal graft fibrosis progression: histologic evaluation of late protocol biopsies.

BACKGROUND Polyomavirus BK (BKV) infection of the renal allograft causes destructive tissue injury with inflammation and subsequent fibrosis. METHODS Using a prospective cohort of patients after kidney transplantation performed between 2003 and 2012, we investigated the role of BKV viraemia in the development and progression of interstitial fibrosis and tubular atrophy (IFTA). The primary outcome was moderate-to-severe IFTA assessed by protocol biopsy at 36 months. RESULTS A total of 207 consecutive recipients were enrolled. Of these, 57 (28%) developed BKV viraemia with 10 (5%) cases of polyomavirus-associated nephropathy (PVAN). Transient (<3 months) BKV viraemia occurred in 70% of patients, and persistent (≥3 months) BKV viraemia in 30%. A high viral load (≥10 000 copies/mL) was detected in 18% and a low viral load (<10 000 copies/mL) in 61%, while the viral load could not be determined in 21%. Moderate-to-severe IFTA was significantly increased in high [71%; odds ratio (OR) = 12.1; 95% confidence interval (CI) 1.62-90.0; P = 0.015] or persistent BKV viraemia (67%; OR = 6.33; 95% CI 1.19-33.7; P = 0.031) with corresponding rise in 'interstitial fibrosis + tubular atrophy' scores. Only patients with transient low BKV viraemia showed similar incidence and progression of IFTA to the no-BKV group. Persistent low BKV viraemia was uncommon yet the progression of fibrosis was significant. Only recipients with PVAN experienced inferior graft survival at 5 years. CONCLUSIONS These data suggest that only transient low BKV viraemia does not negatively affect the progression of allograft fibrosis in contrast to excessive risk of severe fibrosis after high or persistent BKV viraemia.
Clinical utility of tensiomyography for muscle function analysis in athletes

Abstract An exhaustive review has been made to filter the studies that have analyzed muscle function though tensiomyography (TMG) with elite or well-trained athletes. The results of this review indicate that the several protocols used in athletes to find the displacement-time curve with greater maximum radial muscle displacement showed a good-excellent reliability. TMG has been used to characterize athletes’ muscles contractile properties from specific sports disciplines, although there are very few sports that have been deeply analyzed. TMG seems to be useful to determine changes in muscles contractile properties after stimuli of competition, training or recovery. These changes have been strongly related with the fatigue produced after an effort. In addition, TMG parameters could be used to control training effects during a specific period or throughout the season being also a very useful tool to individualize athletes training loads. In this sense, it also seems to provide sports performance information in cyclic sports by relating some TMG parameters with performance indicators. On the other hand, the TMG-BCM algorithm has been used as a lateral and functional symmetry measure and as a monitoring tool for injury prevention and recovery. However, it seems to be no clear criterion that determines asymmetry degree, nor established contractile properties values as a reference to prevent or recover sports injuries. Despite the utility shown in these fields, there are still very few sports analyzed and it is really necessary to continue advancing in the knowledge of the contractile properties behavior, such as the effects of athletes’ training, competitions and injuries and even in the parameters interpretation obtained with the TMG.
Flow Cytometric Assay of Cytochemically Demonstrated NAD(P)H Oxidoreductase (Diaphorase) Activities

The tetrazolium salt 5-cyano-2,3-di-p-toluyl-tetrazolium chloride (CTC), yielding a fluorescent formazan on reduction, was used to measure NAD(P)H oxidoreductase activity. In this study, optimal conditions for the flow cytometric technique were determined empirically with tissue culture cell lines and mouse Ehrlich ascites cells. Applying a coupled reaction procedure, NADH and NADPH as substrates of the oxidoreductases to be measured are generated endogenously by lactate or glucose-6-phosphate dehydrogenase, respectively. The results were evaluated by combining spectrophotometry and flow cytometry. We obtained integral activities for each group of NADH and NADPH oxidoreductases. Furthermore, by counterstaining the DNA with DAPI, followed by bivariate analysis of flow cytometric data, our assay gives a detailed distribution of enzyme activities of all cells, even in subgroups present in heterogeneous cell populations. Therefore, this protocol permits the study of NAD(P)H oxidoreductase activities in ex vivo tumor samples in which mixed cellular populations may be present.
A Comparison of Dynamic Strength Index between Team-Sport Athletes

The purpose of this study was to examine the differences in countermovement jump peak force (CMJ-PF), isometric mid-thigh pull peak force (IMTP-PF), and resultant dynamic strength index (DSI) values between team-sport athletes. One hundred and fifteen male and female team-sport athletes performed the CMJ and IMTP to determine peak force (CMJ-PF and IMTP-PF, respectively). Statistically and practically significant differences (p ≤ 0.050; d = 0.49–1.32) in CMJ-PF were evident between teams. Specifically, the greatest CMJ-PFs were produced by the male cricket players and were followed in order by the male basketball, male soccer, female netball, female cricket, and female soccer players. Statistically and practically significant differences (p ≤ 0.045; d = 0.64–1.78) in IMTP-PF existed among sports teams, with the greatest IMTP-PFs were produced by the male soccer players and were followed in order by the male cricket, male basketball, female netball, female soccer, and female cricket players. Statistically and practically significant differences (p ≤ 0.050; d = 0.92–1.44) in DSI were found between teams. These findings demonstrate that CMJ-PF, IMTP-PF, and DSI differ between sports teams and provide normative data for ballistic and isometric PF measures. Strength and conditioning coaches should consider relative changes in CMJ-PF and IMTP-PF when assessing DSI ratios.
SEC Regulation Fair Disclosure, Information, and the Cost of Capital

We empirically investigate the effects of the adoption of Regulation Fair Disclosure ( Reg FD') by the U.S. Securities and Exchange Commission in October 2000. This rule was intended to stop the practice of selective disclosure,' in which companies give material information only to a few analysts and institutional investors prior to disclosing it publicly. We find that the adoption of Reg FD caused a significant reallocation of information-producing resources, resulting in a welfare loss for small firms, which now face a higher cost of capital. The loss of the selective disclosure' channel for information flows could not be compensated for via other information transmission channels. This effect was more pronounced for firms communicating complex information and, consistent with the investor recognition hypothesis, for those losing analyst coverage. Moreover, we find no significant relationship of the different responses with litigation risks and agency costs. Our results suggest that Reg FD had unintended consequences and that information' in financial markets may be more complicated than current finance theory admits.