Miracle-dz/UniFAR-FTUs huggingface dataset:
Low Risk of Unemployment, Sick Leave, and Work Disability Among Patients with Inflammatory Bowel Disease: A 7-year Follow-up Study of a Danish Inception Cohort

Background:To assess the occurrence and risk of unemployment (UE), sick leave (SL), and work disability (WD) in incident patients with inflammatory bowel disease (IBD) after 7 years of follow-up compared with the background population and to determine outcome predictors. Methods:The study population consisted of patients aged 18 to 67 years (N = 379) from an IBD inception cohort registered January 1, 2003 to December 31, 2004 in the Copenhagen area. Clinical data were retrospectively collected from medical records. Data on UE, SL, and WD were retrieved from national registries. A random subset of the general population (n = 1435) were matched with IBD cases based on sex, age, and residency. The cumulative probabilities of UE, SL, and WD were calculated. A Cox proportional hazard regression was performed to identify possible outcome predictors. Results:There was no difference in UE rates between patients with IBD and controls (P = 0.23). The risk of SL was significantly increased in patients with IBD (hazard ratio 2.0; 95% confidence interval 1.7–2.4). Patients with IBD showed a higher risk of WD (hazard ratio 2.1; 95% confidence interval 1.2–3.8), particularly male patients older than 55 years. The rate of WD in CD (5.8%) was markedly lowered compared with previous studies. Within the IBD population, sex, educational level, disease behavior, smoking status, and surgery were predictors of UE, SL, and WD. Conclusions:The observed increased risk of SL and WD in patients with IBD underscores the need for the early identification of risk factors. A multidisciplinary approach to secure IBD patients' participation in the labor market is recommended.
Multiple Constraints at the Level of TCRα Rearrangement Impact Vα14i NKT Cell Development1

CD1d-restricted NKT cells that express an invariant Vα14 TCR represent a subset of T cells implicated in the regulation of several immune responses, including autoimmunity, infectious disease, and cancer. Proper rearrangement of Vα14 with the Jα18 gene segment in immature thymocytes is a prerequisite to the production of a TCR that can be subsequently positively selected by CD1d/self-ligand complexes in the thymus and gives rise to the NKT cell population. We show here that Vα14 to Jα rearrangements are temporally regulated during ontogeny providing a molecular explanation to their late appearance in the thymus. Using mice deficient for the transcription factor RORγ and the germline promoters T early-α and Jα49, we show that developmental constraints on both Vα and Jα usage impact NKT cell development. Finally, we demonstrate that rearrangements using Vα14 and Jα18 occur normally in the absence of FynT, arguing that the effect of FynT on NKT cell development occurs subsequent to α-chain rearrangement. Altogether, this study provides evidence that there is no directed rearrangement of Vα14 to Jα18 segments and supports the instructive selection model for NKT cell selection.
Classes of Applications for Social Robots: A User Study

The paper introduces an online user study on applications for social robots with 127 participants. The potential users proposed 570 application scenarios based on the appearance and functionality of four robots presented (AIBO, BARTHOC, BIRON, iCat). The items were grouped into 13 categories which are interpreted and discussed by means of four dimensions: public vs. private use, intensity of interaction, complexity of interaction model, and functional vs. human-like appearance. The interpretation lead to three classes of applications for social robots according to the degree of social interaction: (1) Specialized Applications where the robot has to perform clearly defined tasks which are delegated by a user, (2) Public Applications which are directed to the communication with many users, and (3) Individual Applications with the need of a highly elaborated social model to maintain a variety of situations with few people.
Generalized Deep Transfer Networks for Knowledge Propagation in Heterogeneous Domains

In recent years, deep neural networks have been successfully applied to model visual concepts and have achieved competitive performance on many tasks. Despite their impressive performance, traditional deep networks are subjected to the decayed performance under the condition of lacking sufficient training data. This problem becomes extremely severe for deep networks trained on a very small dataset, making them overfitting by capturing nonessential or noisy information in the training set. Toward this end, we propose a novel generalized deep transfer networks (DTNs), capable of transferring label information across heterogeneous domains, textual domain to visual domain. The proposed framework has the ability to adequately mitigate the problem of insufficient training images by bringing in rich labels from the textual domain. Specifically, to share the labels between two domains, we build parameter- and representation-shared layers. They are able to generate domain-specific and shared interdomain features, making this architecture flexible and powerful in capturing complex information from different domains jointly. To evaluate the proposed method, we release a new dataset extended from NUS-WIDE at http://imag.njust. edu.cn/NUS-WIDE-128.html. Experimental results on this dataset show the superior performance of the proposed DTNs compared to existing state-of-the-art methods.
An attachment theoretical approach to women’s faith development: a qualitative study

This study is an exploration of the experience of faith from a psychodynamic perspective. The main purpose of this study is to provide a coherent and convincing account of the roots and characteristics of Christian women’s faith experience which will complement and, in some respects correct, existing accounts. Attachment theory is mainly employed as a conceptual framework for the research and the study pursues attachment as an important key factor for faith development. Examining the patterns of God-attachment in relation to human attachments, this study employs a qualitative methodological approach, focusing analysis on linguistic meanings, and using open-ended and unforced autobiographical narrative in-depth interviews with a group of 10 Korean Christian women. The main findings indicate what the key characteristics in women’s faithing are: the language, means and context with or in which women practice their faith; the relational and affective understanding of faith within the women’s accounts and the interaction of attachment issues in their experience of faith. Three major patterns are identified in which the women’s faithing strategies and their representations of self and God are presented: these are Distance/Avoidance, Anxiety/Ambivalence and Security/Interdependence. Theoretical and practical implications of the findings are identified for Christian education, pastoral care and counselling for women.
Passing On: Kinship and Inheritance in England

Inheritance, once the preserve of the propertied upper classes, has become a much more common experience. Many more people now than in the past have something of material value to bequeath when they die, mainly because of the spread of home ownership during the second half of the twentieth century. Passing On examines what these changes can tell us about kinship in England, through a study of how contemporary families handle inheritance. Based on the findings of a major research project into inheritance and kinship, Passing On examines how it is transmitted, 'who gets what' and the meaning this has for individuals and families. The authors argue that we should understand English kinship as a set of relational practices which are flexible and variable, rather than as a rigid structure or system. Inheritance is characterised more by symbolic practices and moral reasoning than by materialism. Of interest to lecturers and students of sociology, anthropology, social policy, law and gender studies, Passing On is also of considerable interest to those seeking to understand changing forms of kinship and ownership, especially researchers, policy makers and legal practitioners.
Neural Information Retrieval: A Literature Review

A recent "third wave" of Neural Network (NN) approaches now delivers state-of-the-art performance in many machine learning tasks, spanning speech recognition, computer vision, and natural language processing. Because these modern NNs often comprise multiple interconnected layers, this new NN research is often referred to as deep learning. Stemming from this tide of NN work, a number of researchers have recently begun to investigate NN approaches to Information Retrieval (IR). While deep NNs have yet to achieve the same level of success in IR as seen in other areas, the recent surge of interest and work in NNs for IR suggest that this state of affairs may be quickly changing. In this work, we survey the current landscape of Neural IR research, paying special attention to the use of learned representations of queries and documents (i.e., neural embeddings). We highlight the successes of neural IR thus far, catalog obstacles to its wider adoption, and suggest potentially promising directions for future research.
Cognitive impairment: assessment with brain magnetic resonance imaging and proton magnetic resonance spectroscopy.

BACKGROUND In vivo proton magnetic resonance spectroscopy is a safe and noninvasive tool that can be used to study aspects of brain chemistry and metabolism. This study was designed to evaluate its role in routine application to reveal the diagnostic reasons for cognitive impairment. METHOD 37 Alzheimer's disease patients (NINCDS-ADRDA criteria), 31 patients with subcortical ischemic vascular dementia (Chui et al. criteria), and 13 subjects with subjective cognitive impairment (DSM-IV criteria) were included in this retrospective study. Magnetic resonance images were used for atrophy rating; additionally, proton magnetic resonance spectroscopy was performed. RESULTS Significantly reduced N-acetylaspartate levels (p <.05) were found in both patients with Alzheimer's disease and patients with subcortical ischemic vascular dementia compared to the group with subjective memory complaints. The ratios of N-acetylaspartate/creatine and N-acetylaspartate/myo-inositol were significantly lower in Alzheimer's disease patients compared to patients with vascular dementia (p =.012) or patients with subjective memory impairment (p =.002). N-acetylaspartate/creatine and N-acetylaspartate/myo-inositol ratios were positively correlated to the degree of cerebral atrophy. Disoriented patients displayed a low N-acetylaspartate/creatine ratio. In contrast, we were not able to relate concurrent psychotic or behavioral symptoms to any spectroscopic parameter. CONCLUSION This study indicates that proton magnetic resonance spectroscopy parameters could provide additional information in differentiating between Alzheimer's disease, subcortical ischemic vascular dementia, and subjective cognitive impairment. Therefore, this method can contribute to the routine diagnosis of dementia. Psychiatric and behavioral symptoms associated with dementia or due to a major psychiatric disorder cannot be related to changes in the measured proton magnetic resonance spectroscopy parameters.
Gray Matter Increase Induced by Practice Correlates with Task-Specific Activation: A Combined Functional and Morphometric Magnetic Resonance Imaging Study

The neurophysiological basis of practice-induced gray matter increase is unclear. To study the relationship of practice-induced gray matter changes and neural activation, we conducted a combined longitudinal functional and morphometric (voxel-based morphometry) magnetic resonance imaging (MRI) study on mirror reading. Compared with normal reading, mirror reading resulted in an activation of the dorsolateral occipital cortex, medial occipital cortex, superior parietal cortex, medial and dorsolateral prefrontal cortex, as well as anterior insula and cerebellum. Daily practice of 15 min for 2 weeks resulted in an increased performance of mirror reading. After correction for pure performance effects, we found a practice-related decrease of activation at the right superior parietal cortex and increase of activation at the right dorsal occipital cortex. The longitudinal voxel-based morphometry analysis yielded an increase of gray matter in the right dorsolateral occipital cortex that corresponded to the peak of mirror-reading-specific activation. This confirms that short-term gray matter signal increase corresponds to task-specific processing. We speculate that practice-related gray matter signal changes in MRI are primarily related to synaptic remodeling within specific processing areas.
Androgen Replacement in Adolescents and Young Women with Hypopituitarism

The aim of this study was to test the hypothesis that young women with androgen deficiency due to hypopituitarism would benefit from androgen replacement in the form of dehydroepiandrosterone (DHEA). Five young women, age 15.2-23.1 years, with panhypopituitarism were studied in a 12-month double blind placebo-controlled crossover trial of DHEA replacement in a dose 50 mg/day (Belmar Pharmacy, Lakewood, CO). All had growth hormone (GH), thyroid stimulating hormone (TSH), adrenocorticotropic hormone (ACTH) and antidiuretic hormone deficiencies. Gonadotropin deficiency was complete in three and partial in two. The patients were evaluated at baseline, 6 months and 12 months. Serum hormone levels, body composition, lumbar bone mineral density (BMD), exercise capacity and tests of psychological function were performed. DHEA replacement restored serum DHEA levels to normal, 359.8+/-337 ng/dl (12.5+/-11.7 nmol/l). The Life Situation Survey showed significantly better life satisfaction on DHEA than placebo (110 vs 102, p = 0.05). Trends for improved maximal oxygen uptake (VO2), and decreased percent body fat did not reach statistical significance. In conclusion, androgen replacement with DHEA should be considered in young women with panhypopituitarism. Further studies over longer periods in larger groups of patients are necessary to better evaluate the effects of DHEA replacement on BMD, muscle strength and body composition.
Effects of supplementing growing steers with high levels of partially hydrogenated tallow on feed intake, digestibility, live weight gain, and carcass characteristics.

Effects of supplementing growing steers consuming forage-based diets with high levels of partially hydrogenated tallow on feed intake, digestibility, live weight gain, and carcass characteristics were determined in this study. In Exp. 1, Holstein steer calves were fed bermudagrass hay alone (Control) and with a ground corn-based concentrate at . 95% BW (DM basis) plus partially hydrogenated tallow at 0 (Basal), . 33 (low fat; LF), or . 67% BW (high fat; HF) in a Latin square. Total DMI was increased by concentrate supplementation and was lower for HF than for LF (P < .05; 3.18, 3.83, 4.25, and 3.17 kg/d for Control, Basal, LF, and HF, respectively). In Exp. 2, grazing Angus x Hereford steers (270 kg +/- .4 initial shrunk BW) were fed the same supplements as in Exp. 1 for 84 or 98 d and slaughtered. Live weight gain was increased (P < .05) by concentrate supplementation (1.01, 1.34, 1.41, and 1.30 kg/d for Control, Basal, Low, and High, respectively). The concentration of total lipids in longissimus muscle was 2.51, 2.53, 3.05, and 3.03% of wet tissue for Control, Basal, LF, and HF, respectively (Basal > the mean of LF and HF; P < .07); the proportion of palmitic acid in total fatty acids was similar among treatments. Fat supplementation did not markedly affect sensory, taste, or tenderness characteristics of longissimus muscle. In conclusion, supplementing grazing beef steers with high levels of partially hydrogenated tallow, with slaughter at approximately 400-kg shrunk BW, tended to increase fat in longissimus muscle without altering the palmitic acid level in fatty acids, although sensory, taste, and tenderness characteristics were not modified.
2016 Ieee International Conference on Big Data (big Data) Priime: a Generic Framework for Interactive Personalized Interesting Pattern Discovery*

—The traditional frequent pattern mining algorithms generate an exponentially large number of patterns of which a substantial proportion are not much significant for many data analysis endeavors. Discovery of a small number of personalized interesting patterns from the large output set according to a particular user's interest is an important as well as challenging task. Existing works on pattern summarization do not solve this problem from the personalization viewpoint. In this work, we propose an interactive pattern discovery framework named PRIIME which identifies a set of interesting patterns for a specific user without requiring any prior input on the interestingness measure of patterns from the user. The proposed framework is generic to support discovery of the interesting set, sequence and graph type patterns. We develop a softmax classification based iterative learning algorithm that uses a limited number of interactive feedback from the user to learn her interestingness profile, and use this profile for pattern recommendation. To handle sequence and graph type patterns PRIIME adopts a neural net (NN) based unsupervised feature construction approach. We also develop a strategy that combines exploration and exploitation to select patterns for feedback. We show experimental results on several real-life datasets to validate the performance of the proposed method. We also compare with the existing methods of interactive pattern discovery to show that our method is substantially superior in performance. To portray the applicability of the framework, we present a case study from the real-estate domain.
Leader-follower interactions : relations with OCB and sales productivity

Purpose Based on substitutes for leadership theory, the aim of this study is to examine followers' learning goal orientation as a moderator of relationships among transformational leadership, organizational citizenship behavior (OCB) and sales productivity. Design/methodology/approach Data came from 61 food and beverage attendants of a casino, and were analyzed using regression analyses. Findings Transformational leadership was positively related to both OCB and sales productivity. Learning goal orientation moderated the relationship between transformational leadership and OCB, such that transformational leadership was more strongly related to OCB among followers with a low learning goal orientation than among followers with a high learning goal orientation. Research limitations/implications Limitations of the study include the small sample size and cross-sectional research design. Practical implications Organizations could train supervisors to practice a transformational leadership style and to take followers' learning goal orientation into account. Originality/value The findings of this study suggest that, with regard to OCB, a high learning goal orientation of followers may act as a “substitute” for low levels of leaders' transformational leadership.
Home M2M networks: Architectures, standards, and QoS improvement

It is envisioned that home networks will shift from current machine-to-human communications to the machine-to-machine paradigm with the rapid penetration of embedded devices in home surroundings. In this article, we first identify the fundamental challenges in home M2M networks. Then we present the architecture of home M2M networks decomposed into three subareas depending on the radio service ranges and potential applications. Finally, we focus on QoS management in home M2M networks, considering the increasing number of multimedia devices and growing visual requirements in a home area. Three standards for multimedia sharing and their QoS architectures are outlined. Cross-layer joint admission and rate control design is reported for QoS-aware multimedia sharing. This proposed strategy is aware of the QoS requirements and resilience of multimedia services. Illustrative results indicate that the joint design is able to intelligently allocate radio bandwidth based on QoS demands in resource-constrained home M2M networks.
Experiences and challenges of an interprofessional community of practice in HIV and AIDS in Tshwane district, South Africa

Abstract Collaboration amongst stakeholders remains a central tenet to achieving goals in planning, implementation, monitoring and evaluation of HIV and AIDS prevention and care strategies. This paper describes the experiences of members of a health care team who joined efforts to collaborate and form a community of practice (CoP) in HIV and AIDS. Qualitative, exploratory case study methods were used. Twenty-six participants were interviewed. Transcripts from the interviews were subjected to the thematic framework of data analysis. Based on the analysis, three themes emerged as impacting on collaboration and these were: the understanding and expectations of being a CoP member; professionalism and ethics within the CoP and collaboration in HIV and AIDS care. The key findings were that the understanding and expectations from the CoP varied. Ethical principles including respect, trust and confidentiality were identified as key tenets of collaboration and were expressed in various ways. The expectations of being a CoP member, the ethical principles within the CoP all impacted in differing ways on how they collaborated. The implication of this study suggests that consultation during inception and throughout the process, clarification of roles, transparency and respect are cardinal points in professional relationships.
Molecular Characterization of the Di-leucine-based Internalization Motif of the T Cell Receptor (*)

Several cell surface receptors including the T cell receptor (TCR) are phosphorylated and down-regulated following activation of protein kinases. We have recently shown that both phosphorylation of Ser-126 and the presence of the di-leucine sequence Leu-131 and Leu-132 in CD3 are required for protein kinase C (PKC)-mediated TCR down-regulation. To identify additional residues required for PKC-mediated phosphorylation of CD3 and for TCR down-regulation, an alanine scanning of CD3 was done. Mutations of Arg-124, Ser-126, Lys-128, and Gln-129 inhibited both phosphorylation and TCR down-regulation, whereas mutation of Asp-127 only inhibited down-regulation. Further analyses demonstrated a discrepancy between the ability to be phosphorylated on CD3 and to down-regulate the TCR in several transfectants. Phosphorylation was not as strictly dependent on the nature and position of the phosphoacceptor group and basic residues as were the subsequent steps involved in TCR down-regulation. Our results suggest that PKC-mediated TCR down-regulation may be regarded as a two-step process. 1) Recognition and phosphorylation of CD3 by PKC. In this process Arg-124, Ser-126, Lys-128, and Gln-129 are important. 2) Recognition of phosphorylated CD3 by molecules involved in receptor internalization. In this process Ser(P)-126, Asp-127, Leu-131, and Leu-132 are important.
An Approximation Method for Exact Controls of Vibrating Systems

We propose a new method for the approximation of exact controls of a second order infinite dimensional system with bounded input operator. The algorithm combines Russell's “stabilizability implies controllability” principle with the Galerkin method. The main new feature of this work consists of giving precise error estimates. In order to test the efficiency of the method, we consider two illustrative examples (with the finite element approximations of the wave and the beam equations) and describe the corresponding simulations.