Miracle-dz/UniFAR-FTUs huggingface dataset:
A 12-Week Assessment of the Treatment of White Spot Lesions with CPP-ACP Paste and/or Fluoride Varnish

This 12-week clinical study evaluated the impact of 10% CPP-ACP and 5% sodium fluoride varnish regimes on the regression of nonorthodontic white spot lesions (WSLs). The study included 21 children with 101 WSLs who were randomised into four treatment regimes: weekly clinical applications of fluoride varnish for the first month (FV); twice daily self-applications of CPP-ACP paste (CPP-ACP); weekly applications of fluoride varnish for the first month and twice daily self-applications of CPP-ACP paste (CPP-ACP-FV); and no intervention (control). All groups undertook a standard oral hygiene protocol and weekly consultation. Visual appraisals and laser fluorescence (LF) measurements were made in weeks one and twelve. The majority of WSLs in the control and FV groups exhibited no shift in appearance, whereas, in the CPP-ACP and CPP-ACP-FV groups, the lesions predominantly regressed. The visual and LF assessments indicated that the extent of remineralisation afforded by the treatments was of the following order: control ~ FV < CPP-ACP ~ CPP-ACP-FV. Self-applications of CPP-ACP paste as an adjunct to standard oral hygiene significantly improved the appearance and remineralisation of WSLs. No advantage was observed for the use of fluoride varnish as a supplement to either the standard or CPP-ACP-enhanced oral hygiene regimes.
Phoneme Recognition with Large Hierarchical Reservoirs

Automatic speech recognition has gradually improved over the years, but the reliable recognition of unconstrained speech is still not within reach. In order to achieve a breakthrough, many research groups are now investigating new methodologies that have potential to outperform the Hidden Markov Model technology that is at the core of all present commercial systems. In this paper, it is shown that the recently introduced concept of Reservoir Computing might form the basis of such a methodology. In a limited amount of time, a reservoir system that can recognize the elementary sounds of continuous speech has been built. The system already achieves a state-of-the-art performance, and there is evidence that the margin for further improvements is still significant.
Psychological Distress and Resilience in Women Diagnosed with Breast Cancer in Greece

Background: Breast cancer is the most frequent type of cancer among women worldwide, especially in developed countries. To be diagnosed with breast cancer and undergo cancer treatment can be a very stressful event. It is estimated that one-third of cancer patients are dealing with psychological problems, such as anxiety and depression and resilience is a way of coping and overcome life stressors such cancer diagnosis. Purpose: The purpose of this study was to examine resilience in women diagnosed with breast cancer and its association with depression and anxiety. Methods: A cross-sectional study was conducted, 144 women diagnosed with breast cancer answered a questionnaire consisted of four parts: Sociodemographic data, the Patient Health Questionnaire Two-Item Depression Scale, the Generalized Anxiety Disorder Questionnaire and the Connor-Davidson Resilience Scale 25. Results: The majority of the sample belongs to age group 51- 60 years, with the mean age of 53.5 SD±11.7 years. The 59.5% of patients were residents of an urban area, 56.8% were married and 36.5% has 2 children. The mean value of CD-RISC25 was 65.3 SD±17.9, meaning a moderate resilience of cancer patients. The 54.5% of respondents indicated a depressed mood. The anxiety severity measured with the GAD-2, where the mean was 2.1 and 46.8% of patients suffered from high anxiety. Conclusions: According to our results, resilience can negative influence depressive symptomatology. Moreover, lower levels of depression can lead to fewer anxiety symptoms.
Clinicopathological Characteristics of Serrated Polyposis Syndrome in Korea: Single Center Experience

Background/Aim. Serrated polyposis syndrome (SPS) is a rare condition characterized by multiple serrated polyps throughout the colon and rectum. The aim of this study was to evaluate the clinicopathological characteristics of SPS in Koreans. Methods. This retrospective analysis of prospectively collected data was performed using information from the endoscopy, clinical records, and pathology database system of Uijeongbu St. Mary's Hospital. Consecutive patients satisfying the updated 2010 World Health Organization criteria for SPS between June 2011 and May 2014 were enrolled. Results. Of the 17,552 patients who underwent colonoscopies during the study period, 11 (0.06%) met the criteria for SPS. The mean age of these patients was 55.6 years. Ten patients (91%) were males. None had a family history of CRC or a first-degree relative with SPS. Seven patients (64%) had synchronous advanced adenoma. One patient had coexistence of SPS with CRC that was diagnosed at the initial colonoscopy. Five patients (45%) had more than 30 serrated polyps. One of the patients underwent surgery and 10 underwent endoscopic resection. Conclusion. The prevalence of SPS in this study cohort was comparable to that in Western populations. Considering the high risk of CRC, correct diagnosis and careful follow-up for SPS are necessary.
Exact relationship between the entanglement entropies of XY and quantum Ising chains

We consider two prototypical quantum models, the spin-1/2 XY chain and the quantum Ising chain and study their entanglement entropy, S(ℓ,L), of blocks of ℓ spins in homogeneous or inhomogeneous systems of length L. By using two different approaches, free-fermion techniques and perturbational expansion, an exact relationship between the entropies is revealed. Using this relation we translate known results between the two models and obtain, among others, the additive constant of the entropy of the critical homogeneous quantum Ising chain and the effective central charge of the random XY chain.
PDGF-induced glycosaminoglycan synthesis is mediated via phosphatidylinositol 3-kinase.

Platelet-derived growth factor (PDGF)-BB has been shown previously to increase glycosaminoglycan (GAG) synthesis but not DNA synthesis in freshly isolated fetal lung fibroblasts. In the present study, we found that PDGF-BB also enhanced35SO4incorporation into the small, soluble proteoglycan biglycan without affecting biglycan's core protein mRNA expression, suggesting that PDGF-BB mainly affects GAG chain elongation and/or sulfation. PDGF-BB-stimulated GAG synthesis was abrogated by tyrphostin 9, a PDGF receptor-associated tyrosine kinase inhibitor, implying that the stimulatory effect is mediated via the PDGF β-receptor (PDGFR). The intracellular signal transduction pathways that mediate PDGF-BB-stimulated GAG synthesis in fetal lung fibroblasts were investigated. On ligand-induced tyrosine phosphorylation, PDGFR associated with phospholipase C (PLC)-γ1, Ras GTPase activating protein (RasGAP), and phosphatidylinositol 3-kinase (PI3K) but not with the Syp-growth factor receptor-bound protein 2-Son of Sevenless complex. Association of PDGFR with PLC-γ1 and RasGAP followed by their tyrosine phosphorylation failed, however, to activate PLC-γ1, protein kinase C (PKC), and Ras. Neither a PLC-γ inhibitor, U-73122; a PKC inhibitor, calphostin C; nor a mitogen-activated protein kinase kinase inhibitor, PD-98059, inhibited PDGF-BB-induced GAG synthesis. In contrast, PDGF-BB stimulation triggered PDGFR-associated PI3K activity. Both PDGF-BB-induced PI3K activation and GAG synthesis were abolished by the PI3K inhibitors wortmannin and LY-294002. The results suggest that PI3K is a downstream mediator of PDGF-BB-stimulated GAG synthesis in fetal rat lung fibroblasts.
Adolescents’ Experiences of Discrimination and Parent–Adolescent Relationship Quality

Grounded in a cultural–ecological perspective, the goals of this study were to examine the implications of young adolescents’ experiences of racial discrimination for the quality of relationships with mothers and fathers and to test whether sociocultural processes, such as youth ethnic identity and parents’ racial socialization strategies, moderated these linkages. Participants were older and younger adolescents in 176 two-parent African American families who completed questionnaires about their discrimination experiences, ethnic identities, and warmth and conflict in their relationships with parents. Mothers and fathers reported on cultural socialization and preparation for bias practices. Consistent with an emotional spillover hypothesis, discrimination was linked to poorer relationship quality with both mothers and fathers. Youth ethnic identity and mothers’ racial socialization moderated discrimination–relationship linkages. Findings were consistent with prior research on discrimination and highlight the protective nature of some sociocultural processes for family relationships.
Normal Vector Voting: Crease Detection and Curvature Estimation on Large, Noisy Meshes

This paper describes a robust method for crease detection and curvature estimation on large, noisy triangle meshes. We assume that these meshes are approximations of piecewise-smooth surfaces derived from range or medical imaging systems and thus may exhibit measurement or even registration noise. The proposed algorithm, which we call normal vector voting, uses an ensemble of triangles in the geodesic neighborhood of a vertex-instead of its simple umbrella neighborhood-to estimate the orientation and curvature of the original surface at that point. With the orientation information, we designate a vertex as either lying on a smooth surface, following a crease discontinuity, or having no preferred orientation. For vertices on a smooth surface, the curvature estimation yields both principal curvatures and principal directions while for vertices on a discontinuity we estimate only the curvature along the crease. The last case for no preferred orientation occurs when three or more surfaces meet to form a corner or when surface noise is too large and sampling density is insufficient to determine orientation accurately. To demonstrate the capabilities of the method, we present results for both synthetic and real data and compare these results to the G. Taubin (1995, in Proceedings of the Fifth International Conference on Computer Vision, pp. 902-907) algorithm. Additionally, we show practical results for several large mesh data sets that are the motivation for this algorithm.
Chronic Blockade of Phosphatidylinositol 3-Kinase in the Nucleus Tractus Solitarii Is Prohypertensive in the Spontaneously Hypertensive Rat

Phosphatidylinositol 3-kinase (PI3K) within brain stem neurons has been implicated in hypertension in the spontaneously hypertensive rat (SHR). Previously, we demonstrated elevated expression of PI3K subunits in rostral ventrolateral medulla and paraventricular nucleus of SHRs compared with Wistar-Kyoto rats. Here, we considered expression levels of PI3K in the nucleus tractus solitarii, a pivotal region in reflex regulation of arterial pressure, and determined its functional role for arterial pressure homeostasis in SHRs and Wistar-Kyoto rats. We found elevated mRNA levels of p110β and p110Δ catalytic PI3K subunits in the nucleus tractus solitarii of adult (12 to 14 weeks old) SHRs relative to the age-matched Wistar-Kyoto rats (fold differences relative to β-actin: 1.7±0.2 versus 1.01±0.08 for p110β, n=6, P<0.05; 1.62±0.15 versus 1.02±0.1 for p110Δ, n=6, P<0.05). After chronic blockade of PI3K signaling in the nucleus tractus solitarii by lentiviral-mediated expression of a mutant form of p85α, systolic pressure increased from 175±3 mm Hg to 191±6 mm Hg (P<0.01) in SHRs but not in Wistar-Kyoto rats. In addition, heart rate increased (from 331±6 to 342±6 bpm; P<0.05) and spontaneous baroreflex gain decreased (from 0.7±0.07 to 0.5±0.04 ms/mm Hg; P<0.001) in the SHRs. Thus, PI3K signaling in the nucleus tractus solitarii of SHR restrains arterial pressure in this animal model of neurogenic hypertension.
REGIONAL AND DIURNAL VARIATIONS OF RAIN ATTENUATION OBTAINED FROM MEASUREMENT OF RAINDROP SIZE DISTRIBUTION OVER INDONESIA AT KU, KA AND W BANDS

Abstract—The measured raindrop size distribution (DSD) and the International Telecommunication Union Radiocommunication Sector (ITU-R) model have been used to elucidate the regional and diurnal variations of rain attenuation in Indonesia, for Ku-band (13.6GHz), Ka-band (35.6GHz), and Wband (96GHz) frequencies. The DSDs were measured by the Parsivel disdrometer at Kototabang (KT; 100.32◦E, 0.20◦S), Padang (PD; 100.27◦E, 0.54◦S), Pontianak (PT; 109.37◦E, 0.00◦S), Manado (MN; 124.92◦E, 1.55◦N) and Biak (BK; 136.10◦E, 1.18◦S). In general, PD, KT and PT have lower rain attenuation than those at MN and BK, for the same rainfall rate, due to lower concentration of small-sized drops at these sites as reported by a previous study. Considerable differences between the attenuation obtained from the DSD and the ITU-R model are observed at all locations, in particular for very heavy rainfall (R > 50mm/h). For R < 50mm/h, the specific rain attenuation of measured DSD is in fairly good agreement with that obtained from the ITU-R model. The specific rain attenuation obtained from the DSD shows diurnal variation, in agreement with a previous study at KT. The diurnal variation of rain attenuation is dependent on the operating frequency and rainfall rate. At KT and PT, the lowest rain attenuation for Ku-band is observed during 06–12 LT, but during this period the largest attenuation is observed for Kaand W-bands. These phenomena may be due to the increasing role of small and medium-sized drops by increasing frequency.
Disparate effects of training on brain activation in Parkinson disease

Objective: To compare the effects of 2 forms of exercise, i.e., a 6-week trial of treadmill training with virtual reality (TT + VR) that targets motor and cognitive aspects of safe ambulation and a 6-week trial of treadmill training alone (TT), on brain activation in patients with Parkinson disease (PD). Methods: As part of a randomized controlled trial, patients were randomly assigned to 6 weeks of TT (n = 17, mean age 71.5 ± 1.5 years, disease duration 11.6 ± 1.6 years; 70% men) or TT + VR (n = 17, mean age 71.2 ± 1.7 years, disease duration 7.9 ± 1.4 years; 65% men). A previously validated fMRI imagery paradigm assessed changes in neural activation pretraining and post-training. Participants imagined themselves walking in 2 virtual scenes projected in the fMRI: (1) a clear path and (2) a path with virtual obstacles. Whole brain and region of interest analyses were performed. Results: Brain activation patterns were similar between training arms before the interventions. After training, participants in the TT + VR arm had lower activation than the TT arm in Brodmann area 10 and the inferior frontal gyrus (cluster level familywise error–corrected [FWEcorr] p < 0.012), while the TT arm had lower activation than TT + VR in the cerebellum and middle temporal gyrus (cluster level FWEcorr p < 0.001). Changes in fall frequency and brain activation were correlated in the TT + VR arm. Conclusions: Exercise modifies brain activation patterns in patients with PD in a mode-specific manner. Motor-cognitive training decreased the reliance on frontal regions, which apparently resulted in improved function, perhaps reflecting increased brain efficiency.
Saliency Detection based on a Sparsity of Segments Model

In this paper, we propose a region based saliency detection algorithm using a total variation based regularizer. We aim to obtain salient objects that are uniformly highlighted. The use of the regularizer facilitates the removal of textures from the image. This leads to an image that contains piecewise constant gray-valued segments. This texture-free image is sparsely segmented into a small number of regions using the expectation maximization algorithm assuming a Gaussian mixture model. We compute saliency of regions using their intensity and spatial features. The saliency map is then thresholded to obtain the salient regions of the image. Next we employ an image matting technique to extract the exact boundaries of the salient objects from the image. This approach leads to noise-free saliency maps containing uniformly highlighted salient regions. The experimental comparison with existing saliency detection algorithms demonstrates the superiority of the proposed technique.
Growth hormone treatment of premature ovarian failure in a mouse model via stimulation of the Notch-1 signaling pathway

Premature ovarian failure (POF) is a condition affecting 1% of women in the general population, causing amenorrhea, hypergonadotropism and hypoestrogenism before the age of 40. Currently, POF cannot be reversed and, although treatments are available, there is an urgent need for improved treatment strategies. Growth hormone (GH) is a pleiotropic hormone that affects a broad spectrum of physiological functions, from carbohydrate and lipid metabolism to the immune response. GH has previously been used to treat POF in non-transgenic preclinical trials, but the biochemical mechanism underlying these effects are unclear. In the present study, a mouse model of POF was generated using cyclophosphamide. Treatment of POF mice with recombinant mouse growth hormone (rmGH) was revealed to markedly reduce POF histopathology in ovarian tissue, relieve ovarian granulosa cell injury, reduce the number of atretic follicles and significantly increase the number of mature oocytes. Furthermore, an enzyme-linked immunosorbent assay revealed that plasma estradiol levels increased and plasma follicle stimulating hormone levels decreased with time in a group of mice treated with a medium dose of rmGH (0.8 mg/kg) when compared with the POF model group (P<0.05). In addition, reverse transcription-quantitative polymerase chain reaction and immunohistochemical analysis demonstrated elevated levels of Notch-1 signaling pathway factors (Notch1, CBF1, and HES1) in wild-type mice and those treated with medium and high doses of rmGH, but not in those treated with low doses of rmGH. In conclusion, GH may promote ovarian tissue repair, estrogen release and oocyte maturation via activation of the Notch-1 signaling pathway in ovarian tissue.
Intercell Radio Interference Studies in Broadband Wireless Access Networks

Capacity has become of primary importance in broadband wireless access (BWA) networks due to the ever-increasing demand for multimedia services and the possibility of providing wireless Internet, leading to their standardization by IEEE (802.16 WirelessMAN) and ETSI (BRAN HIPERACCESS). The major factor limiting capacity in such systems is interference originating from adjacent cells, namely intercell interference. This paper presents a general analysis of intercell interference for a spectrally efficient BWA cellular configuration. It examines the statistical properties of the carrier-to-interference ratio in both downstream and upstream channels. The focus is on the spatial inhomogeneity of rain attenuation over multiple paths, which is the dominant fading mechanism in the frequency range above 20 GHz, especially when two-layered [i.e., line-of-sight (LOS) and non-LOS] architectures are involved. Besides attenuation from precipitation, various architectural and propagation aspects of local multipoint distribution service systems are investigated through simulations, and worst-case interference scenarios are identified
Cardiopulmonary resuscitation knowledge among nursing students: a questionnaire study

Objective: Nurses are usually first witnesses to in-hospital sudden cardiac arrests. Training of nurses has an impact on the efficiency and outcome of cardiopulmonary resuscitation (CPR), and thus, assessment of CPR knowledge among undergraduate nurses is very important to improve training program. Methods: The questionnaire comprised of three parts about CPR knowledge: the first dealing with general questions to understand the importance of CPR in clinical practice; the second comprising the main goal and accuracy of CPR intervention; and the last consisting of questions targeting the indications, methods, and effectiveness of CPR. Descriptive statistics and multiple response analyses were done by IBM SPSS version 20. Results: The students had good knowledge about the importance of CPR in clinical practice and stood average in knowing its indications and effectiveness. The mean score was 64.62±17.84 out of 100 points. While only 11% of them were completely aware about the universal compression ventilation ratio, 16.2% were aware of the current compression depth. In addition, 21.8% of participants have only indicated the order of CPR being compression, airway, and breathing. Conclusion: Knowledge of CPR is good among the nursing students. However, skills of CPR have to be improved by current training programs at regular intervals. Their knowledge and practical approach have to be updated with the current guidelines in CPR.
A historical analysis of the mature stage of tropical cyclones

The characteristics of tropical cyclone intensity and size during the mature stage are presented. Rooted in the classic description by Herbert Riehl, the mature stage is identified as the period from the time of lifetime maximum intensity to the time of lifetime maximum size. This study is the first to analyse the global climatology of the mature stage of tropical cyclones in detail. Three basic features at the mature stage are observed: the reduction of intensity, the outward expansion of the eyewall, and the increase of tangential wind in the outer primary circulation. Globally, about a quarter of tropical cyclones undergo the mature stage. High intensity at the end of the immature stage favours the likelihood of the occurrence of the mature stage. The intensity reduction during the mature stage is considerable with nearly three‐quarters of cyclones decreasing by more than 10%, which makes the conventional ‘steady‐state’ presumption questionable. The increase in the radius of damaging‐force wind is typically about 50 km, while the decrease in maximum wind speed is typically 20% at the mature stage. However, the average integrated kinetic energy and hence destructive potential increases substantially by about 70%. This is consistent with our finding that most of the highly damaging landfalling hurricanes undergo a mature stage. Intensity downgrades during the mature stage may be misinterpreted as they are mostly not accompanied by an overall danger reduction.