Miracle-dz/UniFAR-FTUs huggingface dataset:
Process of Big Data Analysis Adoption: Defining Big Data as a New IS Innovation and Examining Factors Affecting the Process

This paper defines big data analysis a type3 innovation and extends our previous studies on the adoption/assimilation of innovation technologies. The paper develops a three-stage adoption integrative model based on the past diffusion context literatures. The model utilizes TOE (Technology-Organization-Environment) framework as antecedents of this adoption process. Based on the perception model, we hypothesize how perceived direct/indirect benefit, financial readiness, IS competence, industrial pressure affects big data analysis adoption at the organizational level. These five factors are tested using SEM (Structural Equation Modeling) and our analysis leads to following key findings. (1) Financial readiness, IS competence, and industrial pressure are found to affect adoption stages significantly but we could not find such relationship between perceived direct/indirect benefit and the following stages. (2) IS competition had expansive influence on the overall adoption process. (3) Adoption stage is influenced by external factors, which is industrial pressure for our case. (4) Pre and post stages of adoption are affected by internal resources of organization rather than environments.
Virus Infections and Sudden Death in Infancy: The Role of Interferon-γ

Respiratory infections have been implicated in sudden infant death syndrome (SIDS). As interferon-γ (IFN-γ) is a major response to virus infection, we examined (1) the frequency of single nucleotide polymorphism (SNP), IFNG T + 874A, in SIDS infants, their parents, and ethnic groups with different incidences of SIDS; (2) model systems with a monocytic cell line (THP-1) and human peripheral blood monocytes (PBMC) for effects of levels of IFN-γ on inflammatory responses to bacterial antigens identified in SIDS; (3) interactions between genetic and environmental factors on IFN-γ responses. IFNG T + 874A genotypes were determined for SIDS infants from three countries; families who had a SIDS death; populations with high (Indigenous Australian), medium (Caucasian), and low (Bangladeshi) SIDS incidences. The effect of IFN-γ on cytokine responses to endotoxin was examined in model systems with THP-1 cells and human PBMC. The IFN-γ responses to endotoxin and toxic shock syndrome toxin (TSST-1) were assessed in relation to genotype, gender, and reported smoking. There was a marginal association with IFNG T + 874A genotype and SIDS (p = 0.06). Indigenous Australians had significantly higher proportions of the IFNG T + 874A SNP (TT) associated with high responses of IFN-γ. THP-1 cells showed a dose dependent effect of IFN-γ on cytokine responses to endotoxin. For PBMC, IFN-γ enhanced interleukin (IL)-1β, IL-6, and tumor necrosis factor-α responses but reduced IL-8 and IL-10 responses. Active smoking had a suppressive effect on baseline levels of IFN-γ. There was no effect of gender or genotype on IFN-γ responses to bacterial antigens tested; however, significant differences were observed between genotypes in relation to smoking. The results indicate virus infections contribute to dysregulation of cytokine responses to bacterial antigens and studies on physiological effects of genetic factors must include controls for recent or concurrent infection and exposure to cigarette smoke.
Epidemiologic research on lung damage caused by humidifier disinfectants

In April 2011 a tertiary hospital located in Seoul, Korea reported several cases of severe respiratory distress of unknown origin in young adults. To find the route of transmission, causative agent and patient risk factors of the outbreak, an investigation of the epidemic was initiated. A hospital based case-control study was conducted to indicate that humidifier detergent use was the cause of the outbreak. This information led the Ministry of Health and Welfare of Korea issued an order that humidifier detergents should be withdrawn from the market. Here, we describe the major events of planning, execution, and interpretation of the study, and discussions between researchers and public authorities following the decision to perform an epidemiologic study, chronologically.
Seeking the Single European Electricity Market: Evidence from an Empirical Analysis of Wholesale Market Prices

The objectives of this paper are to assess the progress made towards a single European wholesale electricity market by the end of 2001, and identify remaining sources of economic inefficiency. Statistical analysis of day-ahead prices, in fifteen European locations, show Nord Pool (Scandinavia), and German, wholesale markets were almost perfectly competitive, but frequent price spikes, and reversion to equilibrium levels above marginal generation costs, occurred elsewhere. Daily price changes were well correlated between Nord Pool locations, but not others. Cointegration analysis shows prices were well integrated between all locations, except Spain. Results are consistent with arbitrage trading between locations, and the existence of a single European electricity market. However, the market is inefficient because generating firms exercised market power at some locations, and mechanisms to allocate capacity on congested transmission lines were weak. The European Commission should increase competition by breaking up dominant generating firms, not subsidising transmission capacity construction.
Wish You Were Here? Quasi-Experimental Evidence on the Effect of Education on Attitude Toward Immigrants

We use European Social Survey and Labour Force Survey data to estimate the causal effect of education on European natives' opinion toward immigration exploiting reforms in compulsory education in Europe in the 1960s through the 1990s. Our findings show that higher education leads to a more positive attitude toward immigrants. We also investigate the mechanisms behind the effect of education on attitudes by evaluating both economic and non-economic channels. We find that higher education places individuals in occupations that are less exposed to the negative externalities of migration, although not in sectors/occupations where the share of migrants is necessarily smaller, suggesting that migrants and low-educated natives are complementary rather than substitutes in the labour market. In addition, education alters values and the cognitive assessment of the role of immigration in host societies, with a positive effect on tolerance of diversity and a positive effect on the assessment of immigration's role in host countries. Our findings suggest that education as a policy instrument can increase social cohesion in societies that are subject to large immigration flows.
Four and a Half LIM Domains 1b (Fhl1b) Is Essential for Regulating the Liver versus Pancreas Fate Decision and for β-Cell Regeneration

The liver and pancreas originate from overlapping embryonic regions, and single-cell lineage tracing in zebrafish has shown that Bone morphogenetic protein 2b (Bmp2b) signaling is essential for determining the fate of bipotential hepatopancreatic progenitors towards the liver or pancreas. Despite its pivotal role, the gene regulatory networks functioning downstream of Bmp2b signaling in this process are poorly understood. We have identified four and a half LIM domains 1b (fhl1b), which is primarily expressed in the prospective liver anlage, as a novel target of Bmp2b signaling. fhl1b depletion compromised liver specification and enhanced induction of pancreatic cells from endodermal progenitors. Conversely, overexpression of fhl1b favored liver specification and inhibited induction of pancreatic cells. By single-cell lineage tracing, we showed that fhl1b depletion led lateral endodermal cells, destined to become liver cells, to become pancreatic cells. Reversely, when fhl1b was overexpressed, medially located endodermal cells, fated to differentiate into pancreatic and intestinal cells, contributed to the liver by directly or indirectly modulating the discrete levels of pdx1 expression in endodermal progenitors. Moreover, loss of fhl1b increased the regenerative capacity of β-cells by increasing pdx1 and neurod expression in the hepatopancreatic ductal system. Altogether, these data reveal novel and critical functions of Fhl1b in the hepatic versus pancreatic fate decision and in β-cell regeneration.
Likelihood of repeat abortion in a Swedish cohort according to the choice of post‐abortion contraception: a longitudinal study

Despite high access to contraceptive services, 42% of the women who seek an abortion in Sweden have a history of previous abortion(s). The reasons for this high repeat abortion rate remain obscure. The objective of this study was to study the choice of contraceptive method after abortion and related odds of repeat abortions within 3–4 years.
The American Woman 2003-2004: Daughters of a Revolution - Young Women Today

Introduction A.J.Stone Young Women: Where They Stand M.Farnsworth Riche Generation X in the Labor Force M.DiNatale & S.Boraas Baby Boom to GenX: Progress in Young Women's Health A.Salganicoff, L.Greene, & B.Wentworth Integrating Work and Life: Young Women Forge New Solutions J.DeGroot & J.Fine The Economics of Young Women Today L.Luciano Looking Ahead: A Policy Discussion C.B. Costello & V.R. Wight American Women Today: A Statistical Portrait Demographics Education Health Employment Earnings and Benefits Economic Security Women in the Military Elections and Officials Women in Congress The Congressional Caucus for Women's Issues at 25: Challenges and Opportunities C.Hall Women in the 107th Congress Congressional Caucus for Women's Issues
Protostellar discs formed from turbulent cores

We investigate the collapse and fragmentation of low-mass, trans-sonically turbulent pre-stellar cores, using smoothed particle hydrodynamics simulations. The initial conditions are slightly supercritical Bonnor–Ebert spheres, all with the same density profile, the same mass (MO= 6.1 M⊙) and the same radius (RO= 17 000 au), but having different initial turbulent velocity fields. 400 turbulent velocity fields have been generated, all scaled so that the mean Mach number is . Then, a subset of these (in total 11 setups), having a range of net angular momenta, j, has been evolved. The evolution of these turbulent cores is significantly different from the collapse of a rigidly rotating core. It is not strongly correlated with j. Instead, it is moderated by the formation of filamentary structures due to converging turbulent flows. A high fraction (9 out of 13, ∼69 per cent) of the individual protostars forming from turbulent cores are attended by resolved (R≥ 10 au) protostellar accretion discs, but only a very small fraction (1 out of 9, ∼11 per cent) of these discs is sufficiently cool and extended to develop non-linear gravitational instabilities and fragment. Protostars with discs show two distinct growth modes. They initially grow by direct gravitational collapse, followed by subsequent disc accretion.
Fuzzy semantic annotation of XML documents

The e.dot project consists in the semi-automatic construction of an XML data warehouse in the field of food safety. The construction and the querying of the data warehouse are guided by an ontology. We are working on the annotation of tables extracted from scientific articles in microbiology with terms of the ontology. Terms from those articles may be connected to several terms of the ontology, but each connection is uncertain. We represent the annotations as possibility distributions: we associate each term of the ontology with the degree of possibility that this term represents the original term from the article. In this paper, we present two ways of computing this degree of possibility. One is based on a syntactic comparison, each word of an ontology term being weighted according to its “semantic power” in the term. The second way of computing the degree of possibility is based on the first one, but it also uses the hierarchy defined in the ontology
Rasch analysis of the Persian version of PedsQLTM Oral Health Scale: further psychometric evaluation on item validity including differential item functioning

Background: The study aimed to further evaluate the psychometric properties of one recently developed oral health related quality of life (OHRQoL) instrument (PedsQL Oral Health Scale), including student self-report and parent-proxy report. Specifically, we tested the item validity,threshold order, local dependency, and differential item functioning (DIF) across gender and rater. Methods: This is a cross-sectional study, and study population was recruited in Qazvin, Iran using one-stage sampling with the unit of school. Students and their parents (1529 dyads) separately completed the Persian version of PedsQL Oral Health Scale. The psychometric properties were analyzed using Rasch rating scale model, including item validity, threshold order for response categories, and DIF across gender (boys vs. girls in student self-report) and rater (student self report vs. parent-proxy report). Results: All items had satisfactory in fit and outfit mean square error. One disordering category (the response of often) was found in parent-proxy report, while all categories were ordered in student self-report. All items were DIF-trivial across gender and rater. Conclusion: PedsQL Oral Health Scale is a valid instrument to measure OHRQoL. However, our results indicated that the parent-proxy report was inferior to the student self-report, and healthcare providers should primarily use the student self-report.
Increased human scleral permeability with prostaglandin exposure.

PURPOSE To investigate the effect of prostaglandins (PGs) on the permeability of human sclera in vitro. METHODS Twenty-three pairs of human eye bank eyes were studied. Circular pieces of sclera were cultured in low-serum DMEM/F-12 media. Scleral hydration was assessed by measuring wet and dry weight of scleral cultures incubated with medium for 3 days and with Hanks' buffered saline solution (HBSS) for 4 hours. To assess scleral permeability, organ-cultured scleral tissues were exposed to 100 to 500 nM PGF(2alpha), 17-phenyltrinor PGF(2alpha), or PhXA85 (the active form of latanoprost) for 1, 2, and 3 days. Scleral permeability was measured using a two-chamber Ussing apparatus and rhodamine-dextran polymers dissolved in HBSS (MW = 10,000, 40,000, and 70,000). The movement of each rhodamine-dextran across the cultured sclera was measured using a spectrofluorometer. To understand the biological basis of the permeability change, the media were collected from the treated cultures, and the concentration of MMP-1, 2, and 3 was measured using an enzyme-linked immunosorbent assay. RESULTS There was no difference in scleral hydration among fresh sclera and sclera incubated with medium for 3 days, with HBSS for 4 hours, or with medium for 3 days followed by HBSS for 4 hours. Compared to tracer movement across untreated scleral cultures (1.5 x 10(-6) cm/sec for 10 kDa dextran, 0.7 x 10(-6) cm/sec for 40 kDa dextran, and 0.4 x 10(-6) cm/sec for 70 kDa dextran), exposure to PGF(2alpha), 17-phenyltrinor PGF(2alpha), or PhXA85 each increased scleral permeability in a dose- and time-dependent manner. Increases in permeability were greater with the10 kDa dextran than with the 40 or 70 kDa dextran. The magnitude of these effects was greatest with exposure to PhXA85 and similar with exposure to PGF(2alpha) or 17-phenyltrinor-PGF(2alpha). MMP expression also was significantly increased after PG exposure. These increases were generally time and dose dependent and greater with MMP-2 and -3 than with MMP-1. CONCLUSIONS There is increased permeability of human sclera exposed to various PGs in organ culture. This increased permeability is accompanied by increased expression of MMPS:
Prevalence of tuberculosis in post-mortem studies of HIV-infected adults and children in resource-limited settings: a systematic review and meta-analysis

Objectives:Tuberculosis (TB) is estimated to be the leading cause of HIV-related deaths globally. However, since HIV-associated TB frequently remains unascertained, we systematically reviewed autopsy studies to determine the true burden of TB at death. Methods:We systematically searched Medline and Embase databases (to end 2013) for literature reporting on health facility-based autopsy studies of HIV-infected adults and/or children in resource-limited settings. Using forest plots and random-effects meta-analysis, we summarized the TB prevalence found at autopsy and used meta-regression to explore variables associated with autopsy TB prevalence. Results:We included 36 eligible studies, reporting on 3237 autopsies. Autopsy TB prevalence was extremely heterogeneous (range 0–64.4%), but was markedly higher in adults [pooled prevalence 39.7%, 95% confidence interval (CI) 32.4–47.0%] compared to children (pooled prevalence 4.5%, 95% CI 1.7–7.4%). Post-mortem TB prevalence varied by world region, with pooled estimates in adults of 63.2% (95% CI 57.7–68.7%) in South Asia (n = 2 studies); 43.2% (95% CI 38.0–48.3) in sub-Saharan Africa (n = 9 studies); and 27.1% (95% CI 16.0–38.1%) in the Americas (n = 5 studies). Autopsy prevalence positively correlated with contemporary estimates of national TB prevalence. TB in adults was disseminated in 87.9% (82.2–93.7%) of cases and was considered the cause of death in 91.4% (95% CI 85.8–97.0%) of TB cases. Overall, TB was the cause of death in 37.2% (95% CI 25.7–48.7%) of adult HIV/AIDS-related deaths. TB remained undiagnosed at death in 45.8% (95% CI 32.6–59.1%) of TB cases. Conclusions:In resource-limited settings, TB accounts for approximately 40% of facility-based HIV/AIDS-related adult deaths. Almost half of this disease remains undiagnosed at the time of death. These findings highlight the critical need to improve the prevention, diagnosis and treatment of HIV-associated TB globally.
Alexithymia: a general deficit of interoception

Alexithymia is a sub-clinical construct, traditionally characterized by difficulties identifying and describing one's own emotions. Despite the clear need for interoception (interpreting physical signals from the body) when identifying one's own emotions, little research has focused on the selectivity of this impairment. While it was originally assumed that the interoceptive deficit in alexithymia is specific to emotion, recent evidence suggests that alexithymia may also be associated with difficulties perceiving some non-affective interoceptive signals, such as one's heart rate. It is therefore possible that the impairment experienced by those with alexithymia is common to all aspects of interoception, such as interpreting signals of hunger, arousal, proprioception, tiredness and temperature. In order to determine whether alexithymia is associated with selectively impaired affective interoception, or general interoceptive impairment, we investigated the association between alexithymia and self-reported non-affective interoceptive ability, and the extent to which individuals perceive similarity between affective and non-affective states (both measured using questionnaires developed for the purpose of the current study), in both typical individuals (n = 105 (89 female), mean age = 27.5 years) and individuals reporting a diagnosis of a psychiatric condition (n = 103 (83 female), mean age = 31.3 years). Findings indicated that alexithymia was associated with poor non-affective interoception and increased perceived similarity between affective and non-affective states, in both the typical and clinical populations. We therefore suggest that rather than being specifically associated with affective impairment, alexithymia is better characterized by a general failure of interoception.
Static vs. Dynamic Time Mapping in Radial Composite Indicator Visualization

Composite Indicators (CIs), are a common measurement and benchmarking tool that are used to reflect and measure multidimensional concepts such as digital divides, individual's well-being and more. Measurement iterations produce a series of time-oriented data, which stakeholders as well as the general public might be interested to interpret. Visualization of a CI is highly recommended in order to ease interpretation, and many CI websites use radial solutions to visualize CIs. Yet it is unclear how to visualize the temporal dynamics in radial diagrams. Static solutions, mapping time to small multiples might be challenging due to screen space issues. Dynamic solutions are appealing, yet, there is no clear empirical evidence on benefits of dynamic time coding in radial diagrams. In this paper, we compare static vs. dynamic time mapping using two radial CI visualization methods. The popular Radar chart technique is compared to the innovative Flower chart as used in the well-known OECD Better Life index. We compare users' performance and preferences empirically under formal task taxonomy, adjusted to CI tasks. Results indicate that in general, static time encoding was more effective than dynamic encoding. Still, an in depth analysis showed that the dynamic approach is a feasible and sometimes even better solution for important CIs tasks, leveraged by the fact that users seem to like and enjoy it.
Simulation of Pedestrians Crossing a Street

The simulation of vehicular traffic as well as pedestrian dynamics meanwhile both have a decades long history. The success of this conference series, PED and others show that the interest in these topics is still strongly increasing. This contribution deals with a combination of both systems: pedestrians crossing a street. In a VISSIM simulation for varying demand jam sizes of vehicles as well as pedestrians and the travel times of the pedestrians are measured and compared. The study is considered as a study of VISSIM's con ict area functionality as such, as there is no empirical data available to use for calibration issues. Above a vehicle demand threshold the results show a non-monotonic dependence of pedestrians' travel time on pedestrian demand.
Specific targeting of the GABA-A receptor α5 subtype by a selective inverse agonist restores cognitive deficits in Down syndrome mice

An imbalance between inhibitory and excitatory neurotransmission has been proposed to contribute to altered brain function in individuals with Down syndrome (DS). Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the central nervous system and accordingly treatment with GABA-A antagonists can efficiently restore cognitive functions of Ts65Dn mice, a genetic model for DS. However, GABA-A antagonists are also convulsant which preclude their use for therapeutic intervention in DS individuals. Here, we have evaluated safer strategies to release GABAergic inhibition using a GABA-A-benzodiazepine receptor inverse agonist selective for the α5-subtype (α5IA). We demonstrate that α5IA restores learning and memory functions of Ts65Dn mice in the novel-object recognition and in the Morris water maze tasks. Furthermore, we show that following behavioural stimulation, α5IA enhances learning-evoked immediate early gene products in specific brain regions involved in cognition. Importantly, acute and chronic treatments with α5IA do not induce any convulsant or anxiogenic effects that are associated with GABA-A antagonists or non-selective inverse agonists of the GABA-A-benzodiazepine receptors. Finally, chronic treatment with α5IA did not induce histological alterations in the brain, liver and kidney of mice. Our results suggest that non-convulsant α5-selective GABA-A inverse agonists could improve learning and memory deficits in DS individuals.