Miracle-dz/UniFAR-FTUs huggingface dataset:
Contemporary Crustal Deformation Around Southeast Borderland of Tibetan Plateau

[1] We derive a detailed horizontal velocity field for the southeast borderland of the Tibetan Plateau using GPS data collected from the Crustal Motion Observation Network of China between 1998 and 2004. Our results reveal a complex deformation field that indicates that the crust is fragmented into tectonic blocks of various sizes, separated by strike-slip and transtensional faults. Most notably, the regional deformation includes 10–11 mm/yr left slip across the Xianshuihe fault, � 7 mm/yr left slip across the Anninghe-Zemuhe-Xiaojiang fault zone, � 2 mm/yr right slip across a shear zone trending northwest near the southern segment of the Lancang River fault, and � 3 mm/yr left slip across the Lijiang fault. Deformation along the southern segment of the Red River fault appears not significant at present time. The region south and west of the XianshuiheXiaojiang fault system, whose eastward motion is resisted by the stable south China block to the east, turns from eastward to southward motion with respect to south China, resulting in clockwise rotation of its internal subblocks. Active deformation is detected across two previously unknown deformation zones: one is located � 150 km northwest of and in parallel with the Longmenshan fault with 4–6 mm/yr right-slip and another is continued south-southwestward from the Xiaojiang fault abutting the Red River fault with � 7 mm/yr left slip. While both of these zones are seismically active, the exact locations of faults responsible for such deformation are yet to be mapped by field geology. Comparing our GPS results with predictions of various models proposed for Tibetan Plateau deformation, we find that the relatively small sizes of the inferred microblocks and their rotation pattern lend support to a model with a mechanically weak lower crust experiencing distributed deformation underlying a stronger, highly fragmented upper crust.
Predicting Temporal Exceptions in Concurrent Workflows

Current Workflow Management Systems (WfMS) are capable of managing simultaneous workflows designed to support different business processes of an organization. These departmental workflows are considered to be interrelated since they are often executed concurrently and are required to share a limited number of resources. However, unexpected events from the business environment and lack of proper resources can cause delays in activities. Deadline violations caused by such delays are called temporal exceptions. Predicting temporal exceptions in concurrent workflows is a complex problem since any delay in a task can cause a ripple effect on the remaining tasks from the parent workflow as well as from the other interrelated workflows. In addition, different types of loops are often embedded in the workflows for representing iterative activities, and presence of such control flow patterns in workflows can further increase the difficulty in estimation of task completion time. In this chapter, the authors describe a critical path based approach for predicting temporal exceptions in concurrent workflows that are required to share limited resources. This approach allows predicting temporal exceptions in multiple attempts while workflows are being executed. The accuracy of the proposed prediction algorithm is analyzed based on a number of simulation scenarios. The result shows that the proposed algorithm is effective in predicting exceptions for instances where long duration tasks are scheduled (or executed) at the early phase of the workflow. DOI: 10.4018/978-1-4666-0023-2.ch011
Defining urticarial dermatitis: a subset of dermal hypersensitivity reaction pattern.

BACKGROUND Urticarial dermatitis may represent a useful term for a subset of a reaction pattern designated most commonly as dermal hypersensitivity by pathologists. The term is not commonly used, and requires definition to determine whether it is clinically relevant. OBJECTIVES To define urticarial dermatitis and distinguish it from other urticarial reaction patterns and to review the frequency with which dermatologists can recognize clinical settings that match the biopsy findings of urticarial dermatitis. DESIGN Retrospective analysis of clinical and/or histological diagnosis of urticarial dermatitis, applying strict histological criteria in a center using urticarial dermatitis as a diagnostic term in 190 archived reports. SETTING Tertiary referral dermatopathology service reporting for dermatological practices in Sydney, Australia. MAIN OUTCOME MEASURES The correlation between clinical and histological diagnoses of urticarial dermatitis and alternate diagnoses was analyzed. The frequency of positive immunofluorescence findings for bullous pemphigoid was determined in a subset of patients with urticarial dermatitis in whom this test was ordered to exclude prodromal bullous pemphigoid. RESULTS Urticarial dermatitis was the histological diagnosis in at least 1 biopsy result in 148 patients, and matched the provisional clinical diagnosis in 49 (33.1%) patients. Urticarial dermatitis was the only diagnosis provided in 21 patients. The main alternate clinical diagnoses provided were early bullous pemphigoid or dermatitis herpetiformis (47 patients [31.8%]), dermatitis (39 patients [26.4%]), drug reaction (35 patients [23.6%]), urticarial vasculitis (24 patients [16.2%]), and urticaria (12 patients [8.1%]). In 91 patients with a clinical diagnosis of urticarial dermatitis, the histological diagnosis in at least 1 biopsy result was matched in 49 patients (53.8%); other histological diagnoses included dermatitis (21 patients [23.1%]), papular urticaria (12 patients [13.2%]), drug reaction (6 patients [6.6%]), and urticaria (3 patients [3.3%]). Review of 38 direct immunofluorescent results for prodromal bullous pemphigoid and a biopsy finding of urticarial dermatitis revealed only 3 positive results (7.9%). CONCLUSIONS Urticarial dermatitis seems to be a useful histological and clinical term for a subset of the dermal hypersensitivity reaction pattern. Although the clinical presentation is not restricted to a specific entity, eczema and drug reactions seem to be the most frequent clinical associations; and in a subset of patients, urticarial dermatitis remains as a recognizable reaction pattern. Urticarial dermatitis without eosinophilic spongiosis is not a reliable indicator for bullous pemphigoid, because the findings of immunofluorescence are often negative.
Influences of tongue biomechanics on speech movements during the production of velar stop consonants: a modeling study.

This study explores the following hypothesis: forward looping movements of the tongue that are observed in VCV sequences are due partly to the anatomical arrangement of the tongue muscles, how they are used to produce a velar closure, and how the tongue interacts with the palate during consonantal closure. The study uses an anatomically based two-dimensional biomechanical tongue model. Tissue elastic properties are accounted for in finite-element modeling, and movement is controlled by constant-rate control parameter shifts. Tongue raising and lowering movements are produced by the model mainly with the combined actions of the genioglossus, styloglossus, and hyoglossus. Simulations of V1CV2 movements were made, where C is a velar consonant and V is [a], [i], or [u]. Both vowels and consonants are specified in terms of targets, but for the consonant the target is virtual, and cannot be reached because it is beyond the surface of the palate. If V1 is the vowel [a] or [u], the resulting trajectory describes a movement that begins to loop forward before consonant closure and continues to slide along the palate during the closure. This pattern is very stable when moderate changes are made to the specification of the target consonant location and agrees with data published in the literature. If V1 is the vowel [i], looping patterns are also observed, but their orientation was quite sensitive to small changes in the location of the consonant target. These findings also agree with patterns of variability observed in measurements from human speakers, but they contradict data published by Houde [Ph.D. dissertation (1967)]. These observations support the idea that the biomechanical properties of the tongue could be the main factor responsible for the forward loops when V1 is a back vowel, regardless of whether V2 is a back vowel or a front vowel. In the [i] context it seems that additional factors have to be taken into consideration in order to explain the observations made on some speakers.
Digestion of Human Milk Oligosaccharides by Bifidobacterium breve in the Premature Infant

Objective: The aim of this study was to measure consumption and absorption of human milk oligosaccharides (HMOs) in a cohort of premature infants treated with probiotic Bifidobacterium breve. Methods: Twenty-nine premature infants (median gestational age 28 weeks, range 23–32 weeks) cared for in the neonatal intensive care unit of the King Edward and Princess Margaret Hospital in Perth, Australia, were treated with B breve at a dose of 1.66 billion organisms per day. Samples of feces, urine, and milk were obtained at initiation of the probiotic and again 3 weeks later. 16S ribosomal RNA from the feces was analyzed by next-generation sequencing. Quantitation of HMO content of the milk, urine, and feces was performed using nano-high-performance liquid chromatography-chip/time-of-flight mass spectrometry. Results: There was heterogeneity in colonization with bifidobacteria. “Responders” received milk with higher percentages of fucosylated HMOs and had higher percentages of bifidobacteria and lower percentages of Enterobacteriaceae in their feces than “nonresponders. ” Several individual HMOs in the milk were associated with changes in fecal bifidobacteria over time. Changes over time in milk, fecal, and urine HMOs suggested heterogeneity among HMO structures in consumption by microbes in the gut lumen and absorption from the intestine. Conclusions: Colonization of the premature infant intestinal tract with probiotic B breve is influenced by prebiotic HMOs. B breve is a selective consumer of HMOs in the premature infant.
Population dynamics of choice representation in dorsal premotor and primary motor cortex

Studies in multiple species have revealed the existence of neural signals that lawfully co-vary with different aspects of the decision-making process, including choice, sensory evidence that supports the choice, and reaction time. These signals, often interpreted as the representation of a decision variable (DV), have been identified in several motor preparation circuits and provide insight about mechanisms underlying the decision-making process. However, single-trial dynamics of this process or its representation at the neural population level remain poorly understood. Here, we examine the representation of the DV in simultaneously recorded neural populations of dorsal premotor (PMd) and primary motor (M1) cortices of monkeys performing a random dots direction discrimination task with arm movements as the behavioral report. We show that single-trial DVs covary with stimulus difficulty in both areas but are stronger and appear earlier in PMd compared to M1 when the stimulus duration is fixed and predictable. When temporal uncertainty is introduced by making the stimulus duration variable, single-trial DV dynamics are accelerated across the board and the two areas become largely indistinguishable throughout the entire trial. These effects are not trivially explained by the faster emergence of motor kinematic signals in PMd and M1. All key aspects of the data were replicated by a computational model that relies on progressive recruitment of units with stable choice-related modulation of neural population activity. In contrast with several recent results in rodents, decision signals in PMd and M1 are not carried by short sequences of activity in non-overlapping groups of neurons but are instead distributed across many neurons, which once recruited, represent the decision stably during individual behavioral epochs of the trial.
Linking changes in heart rate variability to mood changes in daily life

Background: Dynamic changes of heart rate are considered as markers for autonomic nervous system (ANS) balance and potentially mood. Objective markers of mood are especially of interest when monitoring mental health conditions such as bipolar disorder (BD) and borderline personality disorder (BPD). Methods: Ambulatory ECG recordings, actigraphy and mood recordings were collected from 13 BD, 10 BPD and 15 healthy participants. A total of246 5-minute segments of ECG with a corresponding mood entry and actigraphy recording were collected. Heart rate variability (HRV) measures were calculated for each segment. Results: Significant effects were found for changes in positive mood on changes in HRV for BD participants (R2=0.076, p=0.009) for mean R-R interval (mRR) and (R2=0.061, p=0.026) for high frequency (HF) frequency power. Similar effects were found for BPD participants for negative mood on mRR (R2=0.126, p=0.014) and on negative mood and HF (R2=0.81, p=0.049). Conclusions: Objective measures, such as HRV, which are shown to be linked to changes in mood could allow better understanding of the relationship between mood and cardiovascular behaviour in mental health disorders. In the future, such metrics could help management of these conditions through adjustments in treatments.
Effects of intervention programs on child and adolescent BMI: A meta-analysis study.

BACKGROUND This meta-analysis study aims to assess the efficacy of school-based and after-school intervention programs on the BMIs of child and adolescents, addressing the correlation between some moderating variables. METHODS We analyzed 52 studies (N = 28,236) published between 2000-2011. RESULTS The overall effect size was 0.068 (P < .001), school (r = .069) and after-school intervention (r = .065). Programs conducted with children aged between 15-19 years were the most effective (r = .133). Interventions programs with boys and girls show better effect sizes (r = .110) than programs that included just girls (r = .073). There were no significant differences between the programs implemented in school and after-school (P = .770). The effect size was higher in interventions lasting 1 year (r = .095), with physical activity and nutritional education (r = .148), and that included 3-5 sessions of physical activity per week (r = .080). The effect size also increased as the level of parental involvement increased. CONCLUSIONS Although of low magnitude (r = .068), the intervention programs had a positive effect in prevention and decreasing obesity in children. This effect seems to be higher in older children's, involving interventions with physical activity and nutritional education combined, with parent's participation and with 1-year duration. School or after-school interventions had a similar effect.
Molecular Detection of Bioluminescent Dinoflagellates in Surface Waters of the Patagonian Shelf during Early Austral Summer 2008

We investigated the distribution of bioluminescent dinoflagellates in the Patagonian Shelf region using “universal” PCR primers for the dinoflagellate luciferase gene. Luciferase gene sequences and single cell PCR tests, in conjunction with taxonomic identification by microscopy, allowed us to identify and quantify bioluminescent dinoflagellates. We compared these data to coincidental discrete optical measurements of stimulable bioluminescence intensity. Molecular detection of the luciferase gene showed that bioluminescent dinoflagellates were widespread across the majority of the Patagonian Shelf region. Their presence was comparatively underestimated by optical bioluminescence measurements, whose magnitude was affected by interspecific differences in bioluminescence intensity and by the presence of other bioluminescent organisms. Molecular and microscopy data showed that the complex hydrography of the area played an important role in determining the distribution and composition of dinoflagellate populations. Dinoflagellates were absent south of the Falkland Islands where the cold, nutrient-rich, and well-mixed waters of the Falklands Current favoured diatoms instead. Diverse populations of dinoflagellates were present in the warmer, more stratified waters of the Patagonian Shelf and Falklands Current as it warmed northwards. Here, the dinoflagellate population composition could be related to distinct water masses. Our results provide new insight into the prevalence of bioluminescent dinoflagellates in Patagonian Shelf waters and demonstrate that a molecular approach to the detection of bioluminescent dinoflagellates in natural waters is a promising tool for ecological studies of these organisms.
Mobile Phone Use and the Risk for Malignant Brain Tumors: A Case-Control Study on Deceased Cases and Controls

We investigated the use of mobile or cordless phones and the risk for malignant brain tumors in a group of deceased cases. Most previous studies have either left out deceased cases of brain tumors or matched them to living controls and therefore a study matching deceased cases to deceased controls is warranted. Recall error is one issue since it has been claimed that increased risks reported in some studies could be due to cases blaming mobile phones as a cause of the disease. This should be of less importance for deceased cases and if cancer controls are used. In this study brain tumor cases aged 20–80 years diagnosed during 1997–2003 that had died before inclusion in our previous studies on the same topic were included. Two control groups were used: one with controls that had died from another type of cancer than brain tumor and one with controls that had died from other diseases. Exposure was assessed by a questionnaire sent to the next-of-kin for both cases and controls. Replies were obtained for 346 (75%) cases, 343 (74%) cancer controls and 276 (60%) controls with other diseases. Use of mobile phones gave an increased risk, highest in the >10 years’ latency group yielding odds ratio (OR) = 2.4, and 95% confidence interval (CI) = 1.4–4.1. The risk increased with cumulative number of lifetime hours for use, and was highest in the >2,000 h group (OR = 3.4, 95% CI = 1.6–7.1). No clear association was found for use of cordless phones, although OR = 1.7, 95% CI = 0.8–3.4 was found in the group with >2,000 h of cumulative use. This investigation confirmed our previous results of an association between mobile phone use and malignant brain tumors.
Explicit and Implicit Stigma of Mental Illness as Predictors of the Recovery Attitudes of Assertive Community Treatment Practitioners.

BACKGROUND While explicit negative stereotypes of mental illness are well established as barriers to recovery, implicit attitudes also may negatively impact outcomes. The current study is unique in its focus on both explicit and implicit stigma as predictors of recovery attitudes of mental health practitioners. METHOD Assertive Community Treatment practitioners (n = 154) from 55 teams completed online measures of stigma, recovery attitudes, and an Implicit Association Test (IAT). RESULTS Three of four explicit stigma variables (perceptions of blameworthiness, helplessness, and dangerousness) and all three implicit stigma variables were associated with lower recovery attitudes. In a multivariate, hierarchical model, however, implicit stigma did not explain additional variance in recovery attitudes. In the overall model, perceptions of dangerousness and implicitly associating mental illness with "bad" were significant individual predictors of lower recovery attitudes. CONCLUSIONS The current study demonstrates a need for interventions to lower explicit stigma, particularly perceptions of dangerousness, to increase mental health providers' expectations for recovery. The extent to which implicit and explicit stigma differentially predict outcomes, including recovery attitudes, needs further research.
A three-dimensional computational model of action potential propagation through a network of individual cells

It has been suggested in the literature that a disorganisation of cardiac tissue at the cellular scale may affect the propagation of the action potential (AP) at the tissue scale, and may play a role in arrhythmia. We developed a model of the myocardium at sub-cellular resolution in which the intracellular space, the cell membrane, and the extracellular space are discretized individually. We tested this approach on small, hand-crafted two- and three-dimensional networks of cells.
Emptying and refilling of slime glands in Atlantic (Myxine glutinosa) and Pacific (Eptatretus stoutii) hagfishes

ABSTRACT Hagfishes are known for their unique defensive slime, which they use to ward off gill-breathing predators. Although much is known about the slime cells (gland thread cells and gland mucous cells), little is known about how long slime gland refilling takes, or how slime composition changes with refilling or repeated stimulation of the same gland. Slime glands can be individually electrostimulated to release slime, and this technique was used to measure slime gland refilling times for Atlantic and Pacific hagfish. The amount of exudate produced, the composition of the exudate and the morphometrics of slime cells were analyzed during refilling, and as a function of stimulation number when full glands were stimulated in rapid succession. Complete refilling of slime glands for both species took 3–4 weeks, with Pacific hagfish achieving faster absolute rates of exudate recovery than Atlantic hagfish. We found significant changes in the composition of the exudate and in the morphometrics of slime cells from Pacific hagfish during refilling. Over successive stimulations of full Pacific hagfish glands, multiple boluses of exudate were released, with exudate composition, but not thread cell morphometrics, changing significantly. Finally, histological examination of slime glands revealed slime cells retained in glands after exhaustion. Discrepancies in the volume of cells released suggest that mechanisms other than contraction of the gland musculature alone may be involved in exudate ejection. Our results provide a first look at the process and timing of slime gland refilling in hagfishes, and raise new questions about how refilling is achieved at the cellular level. Summary: Hagfishes use slime to defend against gill-breathing predators. Exudate collected from individual slime glands shows that recovery of slime takes 3-4 weeks and its composition changes during refilling.