Miracle-dz/UniFAR-FTUs huggingface dataset:
The Basic Public Finance of Public-Private Partnerships

Public-private partnerships (PPPs) have been justified because they release public funds or save on distortionary taxes. However, the resources saved by a government that does not finance the upfront investment are offset by giving up future revenue flows to the concessionaire. If a PPP can be justified on efficiency grounds, the PPP contract that optimally balances demand risk, userfee distortions and the opportunity cost of public funds has a minimum revenue guarantee and a revenue cap. The optimal contract can be implemented via a competitive auction with reasonable informational requirements. The optimal revenue guarantees, revenue sharing agreements and auction mechanisms are different from those observed in the real world. In particular, the optimal contract duration is shorter in demand states where the revenue cap binds. These results also have implications for budgetary accounting of PPPs, as they show that their fiscal impact resembles that of public provision, rather than privatization.
Overlapped block motion compensation

Block motion compensation is a critical component of most efficient video compression algorithms. Applications range from real-time low bit rate teleconferencing codecs to moderate and high bit-rate coding standards currently being considered for CD-ROM video storage and packet video. Recent research has suggested that blocking artifacts can be reduced by applying block motion compensation on overlapped blocks in image frames. In this paper, we formulate overlapped block motion compensation as an optimal linear estimator of pixel intensities given the neighboring block motion estimate in the frame. Applying this framework, we propose a procedure for designing optimal windows for overlapped block motion compensation. When applying block motion compensation with overlapped blocks, the optimal motion vector to apply at each block in an image depends on values of motion vectors in a non-causal neighborhood of that block. Thus, unlike for standard block-based compensation, optimal motion estimates cannot be computed with exhaustive search block- matching algorithms, even with the overlap window incorporated. Instead, we defined a simple iterative procedure for computing optimal motion estimates for overlapped block motion compensation. The performance gains achieved by both optimal motion estimation and optimal overlapped windows are demonstrated in simulations. Together, reductions of up to 30% in displaced frame difference energy are demonstrated compared with standard block motion compensation.
Medical educators: How they define themselves – Results of an international web survey

Abstract Background: Little is known about medical educators’ self-definition. Aims: The aim of this study is to survey an international community of medical educators focusing on the medical educators’ self-definition. Methods: Within a comprehensive, web-based survey, an open question on the participants’ views of how they would define a “medical educator” was sent to 2200 persons on the mailing list of the Association for Medical Education in Europe. The free text definitions were analysed using qualitative thematic analysis. Results: Of the, 2200 medical educators invited to participate, 685 (31.1%) provided a definition of a “medical educator”. The qualitative analysis of the free text definitions revealed that medical educators defined themselves in 13 roles, primarily as “Professional Expert”, “Facilitator”, “Information Provider”, “Enthusiast”, “Faculty Developer”, “Mentor”, “Undergraduate and Postgraduate Trainer”, “Curriculum Developer”, “Assessor and Assessment Creator”, and “Researcher”. Conclusions: Our survey revealed that medical educators predominantly define themselves as “Professional Experts” and identified 12 further self-defined roles of a medical educator, several of which not to have been reported previously. The results can be used to further the understanding of our professional identity.
Sound Localization: Information Theory Analysis

Sound localization has been studied extensively. Curiously, although much is known about factors that affect errors, little is known about factors that influence response time. Three experiments were performed in an attempt to identify the separate influence of each of several different factors. All trials used a single broadband noise signal emanating from one of a subset of six loudspeakers equally spaced around the participant in the azimuthal plane. Both the size of the subset and the balance of relative probabilities from speaker to speaker were altered to evaluate the relationship between information content and the dependent variable, choice reaction time. Choice reaction time was found to be related to the information content of the sound stimulus in all cases. It was also found to be related to the presence of pairs of speakers that were symmetrically opposed in front of and behind the participant. Models of choice reaction time in a sound localization task have clear implications for practice. For example, they suggest that multiple auditory collision warnings may endanger drivers.
Relative Sensitivities to Large-Field Optic-Flow Patterns Varying in Direction and Speed

Motion in depth results in radial optic-flow patterns. Forward motion results in radially expanding patterns, whereas backward motion generates contracting patterns. Radial optic-flow patterns are typically represented with a positive speed gradient, ie zero speed at the point of fixation, and maximum speed at the periphery. However, the actual speed profile in such a stimulus will depend upon the relative depth of objects in the scene. Using large-field stimuli (82 deg diameter) we determined relative sensitivities to radial expansion and contraction patterns and also to various types of speed gradients: positive, negative, random, and flat. We found that, even when large-field stimuli are used, observers are more sensitive to radially contracting patterns than to expanding patterns. Sensitivity to the positive speed gradient was not consistently different from either the negative or random gradients. Sensitivity to the flat gradient depended upon the speed of the stimuli. The finding of greater sensitivity to radial contraction is discussed in terms of the functional requirements involved in the use of optic-flow signals in maintaining balance. On the basis of the present findings, the utility of comparing psychophysical results based on thresholds against physiological data based on suprathreshold stimuli is also discussed.
Diverse Temperate Bacteriophage Carriage in Clostridium difficile 027 Strains

Background The hypervirulent Clostridium difficile ribotype 027 can be classified into subtypes, but it unknown if these differ in terms of severity of C. difficile infection (CDI). Genomic studies of C. difficile 027 strains have established that they are rich in mobile genetic elements including prophages. This study combined physiological studies, electron microscopy analysis and molecular biology to determine the potential role of temperate bacteriophages in disease and diversity of C. difficile 027. Methodology/Principal Findings We induced prophages from 91 clinical C. difficile 027 isolates and used transmission electron microscopy and pulsed-field gel electrophoresis to characterise the bacteriophages present. We established a correlation between phage morphology and subtype. Morphologically distinct tailed bacteriophages belonging to Myoviridae and Siphoviridae were identified in 63 and three isolates, respectively. Dual phage carriage was observed in four isolates. In addition, there were inducible phage tail-like particles (PT-LPs) in all isolates. The capacity of two antibiotics mitomycin C and norfloxacin to induce prophages was compared and it was shown that they induced specific prophages from C. difficile isolates. A PCR assay targeting the capsid gene of the myoviruses was designed to examine molecular diversity of C. difficile myoviruses. Phylogenetic analysis of the capsid gene sequences from eight ribotypes showed that all sequences found in the ribotype 027 isolates were identical and distinct from other C. difficile ribotypes and other bacteria species. Conclusion/Significance A diverse set of temperate bacteriophages are associated with C. difficile 027. The observed correlation between phage carriage and the subtypes suggests that temperate bacteriophages contribute to the diversity of C. difficile 027 and may play a role in severity of disease associated with this ribotype. The capsid gene can be used as a tool to identify C. difficile myoviruses present within bacterial genomes.
Sensitivity Analysis for the Problem of Matrix Joint Diagonalization

We investigate the sensitivity of the problem of nonorthogonal (matrix) joint diagonalization (NOJD). First, we consider the uniqueness conditions for the problem of exact joint diagonalization (EJD), which is closely related to the issue of uniqueness in tensor decompositions. As a byproduct, we derive the well-known identifiability conditions for independent component analysis (ICA) based on an EJD formulation of ICA. We next introduce some known cost functions for NOJD and derive flows based on these cost functions for NOJD. Then we define and investigate the noise sensitivity of the stationary points of these flows. We show that the condition number of the joint diagonalizer and uniqueness of the joint diagonalizer as measured by modulus of uniqueness (as defined in this paper) affect the sensitivity. We also investigate the effect of the number of matrices on the sensitivity. Our numerical experiments confirm the theoretical results.While this paper was under review a few of its results were presented in ICASSP07 conference in Honolulu, HI .
Abnormal Activity in the Precuneus during Time Perception in Parkinson's Disease: An fMRI Study

Background Parkinson's disease (PD) patients are deficient in time estimation. This deficit improves after dopamine (DA) treatment and it has been associated with decreased internal timekeeper speed, disruption of executive function and memory retrieval dysfunction. Methodology/Findings The aim of the present study was to explore the neurophysiologic correlates of this deficit. We performed functional magnetic resonance imaging on twelve PD patients while they were performing a time reproduction task (TRT). The TRT consisted of an encoding phase (during which visual stimuli of durations from 5s to 16.6s, varied at 8 levels were presented) and a reproduction phase (during which interval durations were reproduced by a button pressing). Patients were scanned twice, once while on their DA medication (ON condition) and once after medication withdrawal (OFF condition). Differences in Blood-Oxygenation-Level-Dependent (BOLD) signal in ON and OFF conditions were evaluated. The time course of activation in the brain areas with different BOLD signal was plotted. There were no significant differences in the behavioral results, but a trend toward overestimation of intervals ≤11.9s and underestimation of intervals ≥14.1s in the OFF condition (p<0.088). During the reproduction phase, higher activation in the precuneus was found in the ON condition (p<0.05 corrected). Time course was plotted separately for long (≥14.1s) and short (≤11.9s) intervals. Results showed that there was a significant difference only in long intervals, when activity gradually decreased in the OFF, but remained stable in the ON condition. This difference in precuneus activation was not found during random button presses in a control task. Conclusions/Significance Our results show that differences in precuneus activation during retrieval of a remembered duration may underlie some aspects of time perception deficit in PD patients. We suggest that DA medication may allow compensatory activation in the precuneus, which results in a more accurate retrieval of remembered interval duration.
Linear and nonlinear waves

The study of waves can be traced back to antiquity where philosophers, such as Pythagoras (c.560-480 BC), studied the relation of pitch and length of string in musical instruments. However, it was not until the work of Giovani Benedetti (1530-90), Isaac Beeckman (1588-1637) and Galileo (1564-1642) that the relationship between pitch and frequency was discovered. This started the science of acoustics, a term coined by Joseph Sauveur (1653-1716) who showed that strings can vibrate simultaneously at a fundamental frequency and at integral multiples that he called harmonics. Isaac Newton (1642-1727) was the first to calculate the speed of sound in his Principia. However, he assumed isothermal conditions so his value was too low compared with measured values. This discrepancy was resolved by Laplace (1749-1827) when he included adiabatic heating and cooling effects. The first analytical solution for a vibrating string was given by Brook Taylor (1685-1731). After this, advances were made by Daniel Bernoulli (1700-82), Leonard Euler (1707-83) and Jean d’Alembert (1717-83) who found the first solution to the linear wave equation, see section (3.2). Whilst others had shown that a wave can be represented as a sum of simple harmonic oscillations, it was Joseph Fourier (1768-1830) who conjectured that arbitrary functions can be represented by the superposition of an infinite sum of sines and cosines now known as the Fourier series. However, whilst his conjecture was controversial and not widely accepted at the time, Dirichlet subsequently provided a proof, in 1828, that all functions satisfying Dirichlet’s conditions (i.e. non-pathological piecewise continuous) could be represented by a convergent Fourier series. Finally, the subject of classical acoustics was laid down and presented as a coherent whole by John William Strutt (Lord Rayleigh, 1832-1901) in his treatise Theory of Sound. The science of modern acoustics has now moved into such diverse areas as sonar, auditoria, electronic amplifiers, etc.
The dependence of nitric oxide synthase inhibition caused by cigarette smoking extract on the cellular aging of bovine aortic endothelial cells

Objectives Cigarette smoking had been recorded as the main cause of impaired endothelium- dependent vasodilation in smokers by reducing nitric oxide (NO), a production of endothelial nitric oxide synthase (eNOS). However, the mechanism of NO impairment via eNOS activity is unclear until now. In this study, cell passage is suggested to be a relevant factor to eNOS expression under cigarette smoking stress. Methods Bovine aortic endothelial cells (BAECs) were chosen as the research subject with passages ranking from 6 to 9 (6P to 9P). After exposure of cigarette smoking extract (CSE) solution, MTT assay and Western blot method were performed to check the cell viability as well as eNOS protein concentration. In these experiments, four concentrations of CSE at 0.5, 1, 2, and 4% were selected for treatment. Results Our results showed that cells almost died at 4% of CSE. Besides, eNOS protein mass had a linear decrease under the increase of CSE concentration. In addition, the effect of CSE on eNOS expression was dissimilar between different passages. Conclusions This study indicated that CSE had effect on both cell viability and eNOS expression. Besides, a reduction in protein mass was matched with the decrease of cell viability due to CSE tress. Last but not least, the response of eNOS protein to different concentration of CSE at different passages was disparate, making the hypothesis about cell passage related inhibition of eNOS caused by CSE solution.
Polymer-supported CuPd nanoalloy as a synergistic catalyst for electrocatalytic reduction of carbon dioxide to methane

Significance Photo- and electrochemical CO2 reduction to carbon fuels is not only an attractive solution to the greenhouse effect, but could also become an integral part of a global energy storage strategy with renewable electrical energy sources used to store energy in the chemical bonds of carbon fuels. A novel electrodeposition strategy is reported here for the preparation of highly dispersed, ultrafine metal nanoparticles and nanoalloys on an electroactive polymeric film. It is shown that a bimetallic Cu–Pd nanoalloy exhibits a greater than twofold enhancement in Faradaic efficiency for CO2 reduction to methane compared with a state-of-the-art nanoCu catalyst. The fabrication procedure for the alloy nanoparticles is straightforward and applicable as a general procedure for catalytic electrodes for integrated electrolysis devices. Developing sustainable energy strategies based on CO2 reduction is an increasingly important issue given the world’s continued reliance on hydrocarbon fuels and the rise in CO2 concentrations in the atmosphere. An important option is electrochemical or photoelectrochemical CO2 reduction to carbon fuels. We describe here an electrodeposition strategy for preparing highly dispersed, ultrafine metal nanoparticle catalysts on an electroactive polymeric film including nanoalloys of Cu and Pd. Compared with nanoCu catalysts, which are state-of-the-art catalysts for CO2 reduction to hydrocarbons, the bimetallic CuPd nanoalloy catalyst exhibits a greater than twofold enhancement in Faradaic efficiency for CO2 reduction to methane. The origin of the enhancement is suggested to arise from a synergistic reactivity interplay between Pd–H sites and Cu–CO sites during electrochemical CO2 reduction. The polymer substrate also appears to provide a basis for the local concentration of CO2 resulting in the enhancement of catalytic current densities by threefold. The procedure for preparation of the nanoalloy catalyst is straightforward and appears to be generally applicable to the preparation of catalytic electrodes for incorporation into electrolysis devices.
The association between social stress and global cognitive function in a population-based study: the European Prospective Investigation into Cancer (EPIC)-Norfolk study

Background Stress is thought to exert both positive and negative effects on cognition, but the precise cognitive effects of social stress and individuals' response to stress remain unclear. We aimed to investigate the association between different measures of social stress and cognitive function in a middle- to older-aged population using data from the European Prospective Investigation into Cancer (EPIC)-Norfolk study. Method Participants completed a comprehensive assessment of lifetime social adversity between 1993 and 1997 and the short form of the Mini Mental State Examination (SF-MMSE), an assessment of global cognitive function, during the third health check between 2004 and 2011 (a median of 10.5 years later). A low MMSE score was defined as a score in the bottom quartile (20–26). Results Completed MMSE scores and stress measures were available for 5129 participants aged 48–90 years. Participants who reported that their lives had been more stressful over the previous 10 years were significantly more likely to have low MMSE scores [odds ratio (OR) 1.14, 95% confidence interval (CI) 1.04–1.24 per unit increase in perceived stress], independently of sociodemographic factors, physical and emotional health. The effects were restricted to the highest level of stress and the association was stronger among participants with a lower educational level. Adaptation following life event experiences also seemed to be associated with MMSE scores after adjusting for sociodemographic factors, but the association was attenuated with further adjustment. Conclusions In this generally high-functioning population, individuals' interpretations and responses to stressful events, rather than the events themselves, were associated with cognitive function.
Inequalities in uptake of prenatal screening according to ethnicity and socio‐economic status in the four largest cities of the Netherlands (2011–2013)

In the Netherlands, all women are claimed to have equal access to prenatal screening (PS). Prior research demonstrated substantial inequalities in PS uptake associated with socioeconomic status (SES) and ethnic background. The suggested pathway was a lack of intention to participate in PS among these subgroups. We studied the background of inequalities in PS participation, challenging intention heterogeneity as the single explanation.
Molecular Response of the Acidophilic Iron Oxidizer “Ferrovum” sp. JA12 to the Exposure to Elevated Concentrations of Ferrous Iron

The response to elevated ferrous iron concentrations was investigated in the acidophilic iron oxidizer “Ferrovum” sp. JA12 at transcriptome level. Detoxification of reactive oxygen species appears to be the most important strategy to cope with oxidative stress. The proposed iron oxidation model in “Ferrovum” spp. was supported by the transcriptome data of “Ferrovum” sp. JA12. Several gene candidates of the iron oxidation model are organized in a gene cluster conserved in iron oxidizing betaproteobacteria and zetaproteobacteria possibly indicating a common origin of iron oxidation.
A New Selective Medium for Streptococcus mutans and the Distribution of S. mutans and S. sobrinus and Their Serotypes in Dental Plaque

A new selective medium (MS-MUT) was developed for the isolation of Streptococcus mutans from clinical specimens. The average growth recovery of S. mutans on MS-MUT medium was 72.4% of that on MS medium. Growth of Streptococcus sobrinus was significantly inhibited on the medium with an average recovery of 0.034%. In 103 subjects, S. mutans was detected at 58.3, 75.0 and 95.7% in the dental plaque of caries-free (CF), caries-inactive (CI) and caries-active (CA) subjects, respectively. S. sobrinus was detected in 8.3, 13.6 and 38.3% of CF, CI and CA subjects, respectively. S. sobrinus alone was detected in only 4.3% of CA subjects. The subjects in whom neither S. mutans nor S. sobrinus were detected were 41.6% in CF and 25.0% in CI. The most predominant serotype was c with a 67% detection rate. S. sobrinus, serotypes d or g were usually found together with S. mutans.
DinI and RecX modulate RecA–DNA structures in Escherichia coli K‐12

RecA plays a central role in recombination, DNA repair and SOS induction through forming a RecA–DNA helical filament. Biochemical observations show that at low ratios to RecA, DinI and RecX stabilize and destabilize RecA–DNA filaments, respectively, and that the C‐terminal 17 residues of RecA are important for RecX function. RecA–DNA filament formation was assayed in vivo using RecA–GFP foci formation in log‐phase and UV‐irradiated cells. In log‐phase cells, dinI mutants have fewer foci than wild type and that recX mutants have more foci than wild type. A recAΔ17::gfp mutant had more foci like a recX mutant. dinI recX double mutants have the same number of foci as dinI mutants alone, suggesting that dinI is epistatic to recX. After UV treatment, the dinI, recX and dinI recX mutants differed in their ability to form foci. All three mutants had fewer foci than wild type. The dinI mutant's foci persisted longer than wild‐type foci. Roles of DinI and RecX after UV treatment differed from those during log‐phase growth and may reflect the different DNA substrates, population of proteins or amounts during the SOS response. These experiments give new insight into the roles of these proteins.
Production , Manufacturing and Logistics A stochastic model for risk management in global supply chain networks

With the increasing emphasis on supply chain vulnerabilities, effective mathematical tools for analyzing and understanding appropriate supply chain risk management are now attracting much attention. This paper presents a stochastic model of the multi-stage global supply chain network problem, incorporating a set of related risks, namely, supply, demand, exchange, and disruption. We provide a new solution methodology using the Moreau–Yosida regularization, and design an algorithm for treating the multi-stage global supply chain network problem with profit maximization and risk minimization objectives. 2006 Elsevier B.V. All rights reserved.