Miracle-dz/UniFAR-FTUs huggingface dataset:
Brief report: pediatric cancer, parental coping style, and risk for depressive, posttraumatic stress, and anxiety symptoms.

OBJECTIVE According to the stress and coping goodness of fit model, parents' risk for psychological symptoms was hypothesized to decrease as a function of using emotional regulation and problem appraisal strategies more frequently, and to increase as a function of using problem-solving and avoidant behaviors more frequently to cope with an uncontrollable stressor--pediatric cancer diagnosis. METHODS Parents (N = 150) completed measures of depression, PTSD, anxiety, and coping style. RESULTS Regression analyses revealed that symptoms decreased as a function of using problem appraisal and an emotional regulation strategy (social support) more frequently; and increased as a function of using problem-solving strategies, avoidant coping (substance use), and another emotional regulation strategy (negative self-blame) more frequently. CONCLUSIONS The findings provide some support for the model but suggest that the method of coping (e.g., social support) might be considered in addition to the focus of the coping strategy (e.g., emotional regulation).
Troglitazone and Δ2Troglitazone Enhance Adiponectin Expression in Monocytes/Macrophages through the AMP-Activated Protein Kinase Pathway

Accumulating evidence indicates that the regimen to increase adiponectin will provide a novel therapeutic strategy for inflammation and cardiovascular disorders. Here, we tested the effect of troglitazone (TG) and its newly synthesized derivative, 5-[4-(6-hydroxy-2,5,7,8-tetramethyl-chroman-2-yl-methoxy)-benzylidene]-2,4-thiazolidinedione (Δ2troglitazone, (Δ2TG)), on the adiponectin expression in monocytes/macrophages and the relative mechanisms. The expression of adiponectin was located in macrophages of atherosclerotic lesions from patients and cholesterol-fed rabbits. TG and Δ2TG enhanced adiponectin mRNA and protein expression in THP-1 cells by quantitative real-time PCR, Western blot, and immunocytochemistry. TG induced adiponectin mRNA expression through a PPARγ-dependent pathway whereas Δ2TG enhanced adiponectin mRNA expression through a PPARγ-independent pathway in THP-1 cells. Both TG and Δ2TG enhanced adiponectin mRNA expression through AMP-activated protein kinase (AMPK) activation. TG and Δ2TG decreased the adhesion of THP-1 cells to TNF-α-treated HUVECs and the inhibitory effect was abolished by specific antiadiponectin antibodies. TG- and Δ2TG-induced suppression on monocyte adhesion were inhibited by a selective AMPK inhibitor compound C. Our data suggest that the inhibitory effect of TG and Δ2TG on monocyte adhesion might be at least in part through de novo adiponectin expression and activation of an AMPK-dependent pathway, which might play an important role in anti-inflammation and antiatherosclerosis.
Tumor Necrosis Factor α and Endothelin-1 Increase P-Glycoprotein Expression and Transport Activity at the Blood-Brain Barrier

The ATP-driven drug efflux pump, P-glycoprotein, is a critical and selective element of the blood-brain barrier and a primary impediment to pharmacotherapy of central nervous system (CNS) disorders. Thus, an understanding of how P-glycoprotein function is regulated has the potential to improve CNS therapy. We recently demonstrated rapid (minutes) and reversible inactivation of P-glycoprotein in rat brain capillaries signaled through tumor necrosis factor-α (TNF-α) and endothelin-1 (ET-1), components of the brain's innate immune response. In this study, we examined the longer-term consequences of continuous exposure of rat brain capillaries to low levels of TNF-α and ET-1. Exposing brain capillaries to TNF-α or ET-1 caused a rapid decrease in P-glycoprotein transport activity with no change in transporter protein expression. This was followed by a 2- to 3-h plateau at the low activity level and then by a sharp increase in both transport activity and protein expression. After 6 h, transport activity and transporter protein expression was double that of control samples. TNF-α signaled through TNF-R1, which in turn caused ET release and action through ETA and ETB receptors, nitric-oxide synthase, protein kinase C and nuclear factor-κB (NF-κB) and finally increased P-glycoprotein expression and transport activity. Assuming similar effects occur in vivo, the present results imply a tightening of the selective blood-brain barrier with chronic inflammation and thus reduced efficacy of CNS-acting drugs that are P-glycoprotein substrates. Moreover, involvement of NF-κB raises the possibility that other effectors acting through this transcription factor may have similar effects on this key blood-brain barrier transporter.
Interdecadal changes in the ENSO-monsoon system

Abstract The El Nino–Southern Oscillation (ENSO) and Indian monsoon are shown to have undergone significant interdecadal changes in variance and coherency over the last 125 years. Wavelet analysis is applied to indexes of equatorial Pacific sea surface temperature (Nino3 SST), the Southern Oscillation index, and all-India rainfall. Time series of 2–7-yr variance indicate intervals of high ENSO–monsoon variance (1875–1920 and 1960–90) and an interval of low variance (1920–60). The ENSO–monsoon variance also contains a modulation of ENSO–monsoon amplitudes on a 12–20-yr timescale. The annual-cycle (1 yr) variance time series of Nino3 SST and Indian rainfall is negatively correlated with the interannual ENSO signal. The 1-yr variance is larger during 1935–60, suggesting a negative correlation between annual-cycle variance and ENSO variance on interdecadal timescales. The method of wavelet coherency is applied to the ENSO and monsoon indexes. The Nino3 SST and Indian rainfall are found to be highly coherent, .
University of Birmingham Introduction: rethinking integration. New perspectives on adaptation and settlement in the era of super-diversity

This article outlines key arguments and contributions pertaining to new perspectives on the adaptation and settlement of migrants under conditions of superdiversification and on-going migration “crisis”. We seek to re-ignite interest in the conceptual development of the concept of integration and to stimulate theoretical and research advancement beyond the normative integration paradigm. Given the growing complexity, acceleration of changes and increased interconnectedness across societies as well as diversification of migrants, patterns of migration and modes of operation we argue that the concept of integration, and the ideas that underpin thinking around migrants’ adaptation and settlement more generally, need to be reconsidered. Highlighting a number of different ways of thinking about migrant adaptation and settlement we account not only for the multi-dimensionality of integration processes, but also for the diverse nature of migrants and how the multiple characteristics of individuals shape integration opportunities and challenges. Using perspectives from multiple countries in relation to both voluntary and forced migrants within and outside of the EU, this paper offers a range of theoretical and methodological insights into how the complexity associated with superdiversity might be captured and outlines new ways of conceptualising integration. The article also sets up new research agenda around notions lying behind the concept of integration such as the integration of transnational or transit populations, integration within fluid and superdiverse communities or the relationship between integration and intersectionality with the focus on multiple dimensions, relativeness and modalities of social relations.
Multi-glycoside of Tripterygium wilfordii Hook. f. ameliorates imiquimod-induced skin lesions through a STAT3-dependent mechanism involving the inhibition of Th17-mediated inflammatory responses

Multi-glycoside of Tripterygium wilfordii Hook. f. (GTW) possesses anti-inflammatory and immunosuppressive properties, and has been used as a traditional treatment for psoriasis for many years, although the underlying immunological mechanisms remain poorly understood. The T helper (Th)17 cell response is considered to play a major role in the pathogenesis of psoriasis. Th17 cells are implicated in the mechanism of pathogenesis of imiquimod (IMQ)-induced skin inflammation. Using a mouse model, we demonstrated that GTW protected mice from developing psoriasis-like lesions induced by topical IMQ administration. This protection was associated with significantly decreased mRNA levels of Th17 cytokines such as interleukin (IL)-17A, IL-17F and IL-22 in mouse skin samples as well as fewer IL-17-secreting splenic CD4+ lymphocytes in IMQ-exposed mice. There were no significant effects on the proportion of CD4+ interferon (IFN)-γ+ T cells, CD4+IL-4+ T cells and CD4+CD25+Foxp3+ Treg cells in the spleen cells. Taken together with the unchanged mRNA levels of Th1 cytokine IFN-γ, Th2 cytokine IL-4 and Treg cytokine IL-10 in IMQ-exposed mouse skin following GTW administration, our findings suggest that the immunosuppressive effect of GTW in psoriasis is exerted mainly on Th17 cells, rather than on Th1, Th2 or Treg cells. Furthermore, we showed that GTW suppressed Th17 function through the inhibition of STAT3 phosphorylation. These results have the potential to pave the way for the use of GTW as an agent for the treatment of psoriasis.
Disease Interactions in a Shared Host Plant: Effects of Pre-Existing Viral Infection on Cucurbit Plant Defense Responses and Resistance to Bacterial Wilt Disease

Both biotic and abiotic stressors can elicit broad-spectrum plant resistance against subsequent pathogen challenges. However, we currently have little understanding of how such effects influence broader aspects of disease ecology and epidemiology in natural environments where plants interact with multiple antagonists simultaneously. In previous work, we have shown that healthy wild gourd plants (Cucurbita pepo ssp. texana) contract a fatal bacterial wilt infection (caused by Erwinia tracheiphila) at significantly higher rates than plants infected with Zucchini yellow mosaic virus (ZYMV). We recently reported evidence that this pattern is explained, at least in part, by reduced visitation of ZYMV-infected plants by the cucumber beetle vectors of E. tracheiphila. Here we examine whether ZYMV-infection may also directly elicit plant resistance to subsequent E. tracheiphila infection. In laboratory studies, we assayed the induction of key phytohormones (SA and JA) in single and mixed infections of these pathogens, as well as in response to the feeding of A. vittatum cucumber beetles on healthy and infected plants. We also tracked the incidence and progression of wilt disease symptoms in plants with prior ZYMV infections. Our results indicate that ZYMV-infection slightly delays the progression of wilt symptoms, but does not significantly reduce E. tracheiphila infection success. This observation supports the hypothesis that reduced rates of wilt disease in ZYMV-infected plants reflect reduced visitation by beetle vectors. We also documented consistently strong SA responses to ZYMV infection, but limited responses to E. tracheiphila in the absence of ZYMV, suggesting that the latter pathogen may effectively evade or suppress plant defenses, although we observed no evidence of antagonistic cross-talk between SA and JA signaling pathways. We did, however, document effects of E. tracheiphila on induced responses to herbivory that may influence host-plant quality for (and hence pathogen acquisition by) cucumber beetles.
An Analytical Theory of Mathematical Morphology

We extend morphology to tangential morphology of diierentiable surfaces, described by set-valued functions. We show that there is a preserved logarithmic inner product, and a standard basis of morphological eigenfunctions. The components on this basis form the slope transform. In (logarithmic) analogy to linear signal processing, the slope transform of a dilation equals the sum of the slope transforms.
Critical Overview on Organic Legislation for Animal Production: Towards Conventionalization of the System?

Adoption of organic animal production legislation, particularly at the Community level, is done with a spirit of compromise and an attempt to reach consensus. In this sense, legal tools are used to solve technical problems so that an appreciable number of derogations (exceptions) are introduced. These may allow the use of certain feed additives, tethered animals or even application of castration. However, derogations should be avoided in legislation where harmonization is pursued, since they bring about distortion in the marketing of organic products. The validity of these derogations has expiry dates. However, at least the EU was hesitant to proceed with the necessary amendments to lift these derogations so that eliminate ambiguities and block loopholes. In turn, mention is made to geographical issues raised from the exceptions question posed again with the new EU Regulations. Furthermore some thoughts are expressed concerning the relationship between setting standards and the crucial role of values in agriculture, organic in particular, social aspects and pursued policy. Finally, the essential feature of this work is that derogations in legislation inevitably lead to conventionalization of organic animal production, which necessitates the clear definition of “organic”. To substantiate this, relevant arguments are put forward.
A comparison of narrative skill in Spanish-English bilinguals and their functionally monolingual Spanish-speaking and English-only peers

Purpose: The Spanish and English narrative skills of young (mean age = 5.65 years) Spanish-English bilinguals were compared to functionally monolingual Spanish and English-only speakers’ narrative skills, respectively (n = 63). Method: Spanish and English oral retellings, elicited at the beginning and end of the kindergarten year, were transcribed and coded in terms of discourse- (story structure complexity), semantic- (word diversity) and grammatical-level (lexical and grammatical errors, revisions) skills. Data and analysis: Repeated measures ANOVAs, with Time (beginning-, end-of-year) and Language Status (bilingual and either functionally monolingual Spanish or English monolingual) or Language (English, Spanish) as factors, were used to compare children’s narratives in terms of story structure complexity, word diversity, errors and revisions. Pearson correlations examined the relation of revisions to word diversity and errors. Results: Time comparisons revealed significant gains in story structure complexity, with no statistically significant difference between bilinguals’ and monolinguals’ complexity scores. Bilinguals’ stories were also not different between English and Spanish. Yet, bilinguals included more errors in English than did English monolinguals, while engaging in a comparable number of revisions. Moreover, despite comparable error rates with Spanish monolinguals, bilinguals included more lexical and grammatical revisions in Spanish. Revisions and word diversity were positively correlated; no relation was found between revisions and errors. Conclusions: The relative differences in revisions between bilinguals’ and Spanish monolinguals’ narratives, versus English monolinguals’, highlight the linguistic strengths of bilinguals. In particular, bilinguals’ tendency to engage in revisions as they attempt to increase their language complexity, suggests that revisions require advanced linguistic knowledge, not language uncertainty. Originality: The children in this study were considered language minority learners in the United States. Moving past accounts of minority learners’ “low” performance on oral language and reading comprehension, our study findings reveal evidence of “advanced” linguistic knowledge for bilingual speakers.
Corporate Social Responsibility and Competitiveness within SMEs of the Fashion Industry: Evidence from Italy and France

Our paper analyses the link between the adoption of corporate social responsibility (CSR) and competitiveness performance among small and medium enterprises operating in the fashion industry. The study refers to a sample of 213 SMEs (Small and Medium sized Enterprises) located in Italy and France and is based on a correlation analysis between competitiveness variables and the CSR practice adopted. The results show a significant correlation with regard to the innovation process, both from the technical and the organizational point of view, and the intangible performances. On the other hand, another competitiveness macro-category, which is the market performance (measured as demand trend, turnover and business attraction), presents deceptive results, although a positive correlation with the adoption of market-oriented CSR practice emerges. The study is explorative and represents a relevant basis to future studies concerning the nature of the emerged co-relations.
Space/Population and Time/Age in DNA methylation variability in humans: a study on IGF2/H19 locus in different Italian populations and in mono- and di-zygotic twins of different age

Little is known about the impact of space (geography/ancestry) and time (age of the individuals) on DNA methylation variability in humans. We investigated DNA methylation of the imprinted IGF2/H19 locus in: i) a cohort of individuals homogeneous for age and gender (males with restricted age range: 30-50 years) belonging to four Italian districts representative of the major genetic clines, informative for the geographical dimension; ii) a cohort of monozygotic (MZ) and dizygotic (DZ) twins of different ages (age-range: 22-97 years), informative for the temporal dimension. DNA methylation of the analyzed regions displayed high levels of inter-individual variability that could not be ascribed to any geographical cline. In MZ twins we identified two IGF2/H19 regions where the intra-couple variations significantly increased after the age of 60 years. The analysis of twins’ individual life histories suggests that the within twin pairs difference is likely the result of the aging process itself, as sharing a common environment for long periods had no effect on DNA methylation divergence. On the whole, the data here reported suggest that: i) aging more than population genetics is responsible for the inter-individual variability in DNA methylation patterns in humans; ii) DNA methylation variability appears to be highly region-specific.
An Analysis of Ratings Assigned to String Musicians’ Performances at Solo and Ensemble Music Performance Assessment Events

The purpose of this study was to identify the influence of event type (solo and ensemble), school level (middle and high school), and event level (district and state) on overall performance ratings assigned to string musicians attending solo and ensemble festivals. Data consisted of participants’ (N = 10,275) ratings from district - and state-level solo and ensemble festivals sponsored by the Florida Orchestra Association from 2010 to 2014. Participants performed more solo events (n = 6,745) than ensembles (n = 3,530). Performances by middle school string players (n = 5,403) outnumbered those from high school (n = 4,872). Ninety-five percent of all participants (n = 9,761) earned a I/Superior or II/Excellent rating. Solo performances received more favorable ratings than ensemble performances at district festivals. However, ensembles were assigned more favorable ratings at state festivals. Evaluations of middle and high school participants’ performances were similar. District festival performances received more favorable ratings than state festival performances. With the increased importance of student data, student participation at adjudicated festivals, and providing a positive musical experience for students, directors may use these results to help their students receive beneficial assessments that influence long-term success.
Maps of Bounded Rationality: Psychology for Behavioral Economics

The work cited by the Nobel committee was done jointly with Amos Tversky (1937-1996) during a long and unusually close collaboration. Together, we explored the psychology of intuitive beliefs and choices and examined their bounded rationality. Herbert A. Simon (1955, 1979) had proposed much earlier that decision makers should be viewed as boundedly rational, and had offered a model in which utility maximization was replaced by satisficing. Our research attempted to obtain a map of bounded rationality, by exploring the systematic biases that separate the beliefs that people have and the choices they make from the optimal beliefs and choices assumed in rational-agent models. The
The ecology of lizard reproductive outputgeb

Aim We provide a new quantitative analysis of lizard reproductive ecology. Comparative studies of lizard reproduction to date have usually considered life-history components separately. Instead, we examine the rate of production (productivity hereafter) calculated as the total mass of offspring produced in a year. We test whether productivity is influenced by proxies of adult mortality rates such as insularity and fossorial habits, by measures of temperature such as environmental and body temperatures, mode of reproduction and activity times, and by environmental productivity and diet. We further examine whether low productivity is linked to high extinction risk.
Characteristics of Students Sensory Mathematical Imagination in Solving Mathematics Problem

This study aim to investigate the characteristics of students’ sensory mathematical imagination of in solving mathematics problems. This study includes qualitative research with two students of VIII grade junior high school used as subjects. To determine the characteristics of students sensory mathematical imagination who appeared in solving mathematics problems, researchers use the problem sheet as a supporting instrument in this study. The problem sheet consists of a question item that serves to stimulate appear of students sensory mathematical imagination. For accuracy of data using triangulation method of observation, students answers, and interviews. The results showed characteristics of students sensory mathematical imagination in solving mathematics problems is appear of the idea based on perception due to stimulate of the problem, actualization information by analogy according to what people think, the activity involves body movement (sensory motor), can be seen through visual representation.
Revision and Validation of an Instrument Measuring Managerial Coaching Skills in Organizations.

With the increasing attention on managerial coaching as an effective leadership initiative in organizations, there have been increasing needs for reliable and valid tools to assess managers’ coaching skills. This study reviewed and revised an existing instrument measuring coaching skills in organizations created by McLean, Yang, Kuo, Tolbert, and Larkin (2005). Through qualitative and quantitative efforts, this study identified five dimensions of managerial coaching skills and validated the revised instrument measuring coaching skills in organizations.
H∞ state-feedback controller design for discrete-time fuzzy systems using fuzzy weighting-dependent Lyapunov functions

For discrete-time Takagi-Sugeno (TS) fuzzy systems, we propose an H/sub /spl infin// state-feedback fuzzy controller associated with a fuzzy weighting-dependent Lyapunov function. The controller, which is designed via parameterized linear matrix inequalities (PLMIs), employs not only the current-time but also the one-step-past information on the time-varying fuzzy weighting functions. Appropriately selecting the structures of variables in the PLMIs allows us to find an LMI formulation as a special case.