Miracle-dz/UniFAR-FTUs huggingface dataset:
Depression in anorexia nervosa: a risk factor for osteoporosis.

CONTEXT Both anorexia nervosa (AN) and depression are associated with osteoporosis. We hypothesized that adolescent girls with AN and depression will have lower bone mineral density (BMD) than anorexic girls without depression. OBJECTIVE The objective of this study was to investigate whether depression is an independent risk factor for osteoporosis in anorexic adolescent girls. DESIGN This study was cross-sectional. SETTING This study was conducted at the University Children's Hospital (Bialystok, Poland) from October 2002 through September 2003. PARTICIPANTS Forty-five Caucasian anorexic girls aged 13-23 yr, matched by age, Tanner stage, weight, height, calcium intake, and duration of AN, were studied, including 14 with comorbid depression (based on Hamilton Depression Rating Scale and Montgomery-Asberg Depression Rating Scale) and 31 anorexic girls without depression. MAIN OUTCOME MEASURES Total body and lumbar spine (LS) BMD, fat mass, and lean mass assessed using dual-energy x-ray absorptiometry were compared between AN girls with and without depression. RESULTS BMD was reduced in both groups, relative to reference data, but girls with AN and depression had lower BMD than those with AN alone (LS Z-scores, -2.6 +/- 0.3 vs. -1.7 +/- 0.3; P = 0.02) (mean +/- sem). Quantitative assessment of depression correlated independently with total body BMD (r = -0.4; P < 0.05) and LS BMD (r = -0.6; P < 0.001). CONCLUSION Anorexic girls with depression are at higher risk of osteoporosis than those without depression. The mechanisms responsible for decreased BMD in depression are not known. Independent treatment of the depressive disorder in AN may partly alleviate the bone fragility.
Gold nanoparticles enhance TRAIL sensitivity through Drp1-mediated apoptotic and autophagic mitochondrial fission in NSCLC cells

Although tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and its agonistic receptors have been identified as highly promising antitumor agents preferentially eliminating cancer cells with minimal damage, the emergence of TRAIL resistance in most cancers may contribute to therapeutic failure. Thus, there is an urgent need for new approaches to overcome TRAIL resistance. Gold nanoparticles (AuNPs) are one of the most promising nanomaterials that show immense antitumor potential via targeting various cellular and molecular processes; however, the effects of AuNPs on TRAIL sensitivity in cancer cells remain unclear. In this study, we found that AuNPs combined with TRAIL exhibited a greater potency in promoting apoptosis in non-small-cell lung cancer (NSCLC) cells compared with TRAIL alone, suggesting that AuNPs sensitize cancer cells to TRAIL. Further experiments demonstrated that the combination of TRAIL and AuNPs was more effective in causing excessive mitochondrial fragmentation in cancer cells accompanied by a dramatic increase in mitochondrial recruitment of dynamin-related protein 1 (Drp1), mitochondrial dysfunctions, and enhancement of autophagy induction. Small interfering RNA (siRNA) silencing of Drp1 or inhibition of autophagy could effectively alleviate apoptosis in cells exposed to TRAIL combined with AuNPs. In vivo studies revealed that AuNPs augmented TRAIL sensitivity in tumor-bearing mice. Our data indicated that AuNPs potentiate apoptotic response to TRAIL in NSCLC cells through Drp1-dependent mitochondrial fission, and TRAIL combined with AuNPs can be a potential chemotherapeutic strategy for the treatment of NSCLC.
Night-to-night variability of disturbed breathing during sleep in an elderly community sample.

Night-to-night variability of breathing and oxygenation during sleep was examined with portable monitoring equipment in 30 residents of a retirement village. Subjects had a variety of health problems as might be expected in the elderly, but all were living independently in self-contained units. None had clinical features to suggest obstructive sleep apnea. Two pairs of consecutive nights were studied, separated by 4-6 months. Satisfactory recordings on all four nights were obtained in 15 subjects, and in these subjects variability of measurements was examined across nights 1-4 using the kappa (K) statistic. There was low but significant agreement in estimated total sleep time (K = 0.23, p less than 0.01) and estimated wakefulness after sleep onset (K = 0.18, p less than 0.05) as assessed with a wrist actigraph. Good agreement was found among measures of disturbed breathing during sleep whether expressed in terms of numbers of events [respiratory disturbance index (RDI), K = 0.62, p less than 0.0001], their duration (event minutes, K = 0.53, p less than 0.0001), or associated disturbance of oxygenation (% cumulative time less than 90% SaO2, K = 0.50, p less than 0.001, n = 9). Twenty-eight subjects had at least two nights' satisfactory recordings. Although some of these individuals showed considerable variation in RDI, this had little overall effect on classification of them into normal (RDI less than or equal to 15) and abnormal groups. The accuracy of the first night's recording in predicting classification derived from recording on three or four nights was 83%. (ABSTRACT TRUNCATED AT 250 WORDS)
A new approach for biocrust and vegetation monitoring in drylands using multi-temporal Sentinel-2 images

Drylands, one of the planet’s largest terrestrial biomes, are suggested to be greatly threatened by climate change. Drylands are usually sparsely vegetated, and biological soil crusts (biocrusts) – that is, soil surface communities of cyanobacteria, mosses and/or lichens – can cover up to 70% of dryland cover. As they control key ecosystem processes, monitoring their spatial and temporal distribution can provide highly valuable information. In this study, we examine the potential of European Space Agency’s (ESA) Sentinel-2 (S2) data to characterize the spatial and temporal development of biocrust and vascular plant greening along a rainfall gradient of the Negev Desert (Israel). First, the chlorophyll a absorption feature in the red region (CRred) was identified as the index mostly sensitive to changes in biocrust greening but minimally affected by changes in soil moisture. This index was then computed on the S2 images and enabled monitoring the phenological dynamics of different dryland vegetation components from August 2015 to August 2017. The analysis of multi-temporal S2 images allowed us to successfully track the biocrust greening within 15 days from the first seasonal rain events in the north of Negev, and to identify the maximum development of annual vascular plants and greening of perennial ones. These results show potential for monitoring arid and semi-arid environments using the newly available S2 images, allowing new insights into dryland vegetation dynamics.
Quantitative trait loci mapping for meat quality traits in swine chromosome 6

The current study was carried out to perform QTL mapping on swine chromosome 6 (SSC6) associated to meat quality traits. The F2 population was produced by outbreed crossing using two native Brazilian breed Piau boars and 18 commercial sows. A total of 557 F2 animals were genotyped for 13 microsatellite markers. The traits evaluated on the F2 population were: pH measured 45 minutes and 24 hours post mortem (pH 45, pH24, respectively), drip loss (DL), cooking loss (CL), total loss (TL), intramuscular fat content (IMF), objective tenderness (OT), lightness (L), redness (A), yellowness (B), hue angle (h) and chrome (c). Data were analyzed by multiple regression developed for analysis of outbreed line crosses, using the QTL Express Software. Significant QTL were detected for pH45 and DL traits, and suggestive QTL for DL. QTL were not found for other traits. The pH45 and DL traits may be under the influence of one gene or a gene group located at about 76, 88 and 97cM. More markers should be included in the regions where F-value peaks and suggestive QTL for the DL trait were detected to ascertain whether they are real QTL.
Collaborative puzzle game: a tabletop interface for fostering collaborative skills in children with autism spectrum disorders

Tabletop interfaces are a novel class of technologies that are particularly suited to support co‐located collaboration. The Collaborative Puzzle Game (CPG) is a tabletop interactive activity developed for fostering collaboration skills in children with Autism Spectrum Disorders (ASD). The CPG features an interaction rule called Enforced Collaboration (EC); in order to be moved, puzzle pieces must be touched and dragged simultaneously by the two players. Two studies were conducted to test the effect of EC on collaboration. In Study I, 70 typically developing boys were tested in pairs to characterise the way they respond to EC; in Study II, 16 boys with ASD were tested in pairs. Results suggest that EC has a generally positive effect on collaboration and is associated with more complex interactions. For children with ASD, the EC interaction rule was effective in triggering behaviours associated with co‐ordination of the task and negotiation.
Validation of Personal Identity as a Terror Management Mechanism: Evidence that Sex-Role Identity Moderates Mortality Salience Effects

Two studies examined the effects of mortality salience on the willingness to interact with sex-typed and cross-sex-typed stereotypic targets while assessing the moderating role of sex-role identity. In both studies, Israeli adolescent participants completed the Bem Sex-Role Inventory, were exposed to a mortality salience or control induction, and rated their willingness to interact with two same-sex targets that were defined by either feminine or masculine stereotypic traits. Study 1 included 169 boys; Study 2 consisted of 200 girls. Results from both studies indicated that mortality salience led sex-typed individuals (masculine boys, feminine girls) to report less willingness to interact with same-sex peers who are cross-sex-typed. In contrast, mortality salience led cross-sex-typed individuals (feminine boys, masculine girls) to report more willingness to interact with same-sex peers who are cross-sex-typed. Findings were discussed in light of the function of personal identity validation as a possible terror management mechanism.
Functional role of the C‐terminal tail of the archaeal ribosomal stalk in recruitment of two elongation factors to the sarcin/ricin loop of 23S rRNA

Two types of elongation factors alternate in their binding to the factor‐binding center of the ribosome. Both binding events are accompanied by GTP hydrolysis and drive the translation elongation cycle. The multicopy ribosomal protein family, termed the stalk, contributes actively to the elongation process. Recent evidence indicates that the mobile C‐terminal tail of archaeal stalk aP1 directly interacts with both the elongation factors aEF1A and aEF2. To investigate the functional significance of these interactions in recruitment of elongation factors to the factor‐binding center of the ribosome, we substituted the archaeal stalk complex aL10•aP1 for the bL10•bL12 stalk complex in the Escherichia coli 50S subunit. The resultant hybrid ribosome accessed archaeal aEF1A and aEF2 in a manner dependent on the C‐terminal tail containing the hydrophobic residues Leu103, Leu106 and Phe107. Bases G2659 and A2660 in the sarcin/ricin loop (SRL) of 23S rRNA were protected against DMS modification by both factors as was A1067 by aEF2. Mutagenesis indicated that this protection was dependent on the intact C‐terminal tail of aP1. The results suggest a crucial role for the interactions between the stalk C‐terminal tail and elongation factors in their recruitment to the SRL of 23S rRNA within the ribosome.
Multi-model hypothesize-and-verify approach for incremental loop closure verification

Loop closure detection, which is the task of identifying locations revisited by a robot in a sequence of odometry and perceptual observations, is typically formulated as a visual place recognition (VPR) task. However, even state-of-the-art VPR techniques generate a considerable number of false positives as a result of confusing visual features and perceptual aliasing. In this paper, we propose a robust incremental framework for loop closure detection, termed incremental loop closure verification. Our approach reformulates the problem of loop closure detection as an instance of a multi-model hypothesize-and-verify framework, in which multiple loop closure hypotheses are generated and verified in terms of the consistency between loop closure hypotheses and VPR constraints at multiple viewpoints along the robot's trajectory. Furthermore, we consider the general incremental setting of loop closure detection, in which the system must update both the set of VPR constraints and that of loop closure hypotheses when new constraints or hypotheses arrive during robot navigation. Experimental results using a stereo SLAM system and DCNN features and visual odometry validate effectiveness of the proposed approach.
Comprehending and Learning From Internet Sources: Processing Patterns of Better and Poorer Learners

Readers increasingly attempt to understand and learn from information sources they find on the Internet. Doing so highlights the crucial role that evaluative processes play in selecting and making sense of the information. In a prior study, Wiley et al. (2009, Experiment 1) asked undergraduates to perform a web‐based inquiry task about volcanoes using multiple Internet sources. A major finding established a clear link between learning outcomes, source evaluations, and reading behaviors. The present study used think‐aloud protocol methodology to better understand the processing that learners engaged in during this task: 10 better learners were contrasted with 11 poorer learners. Results indicate that better learners engaged in more sense‐making, self‐explanation, and comprehension‐monitoring processes on reliable sites as compared with unreliable sites, and did so by a larger margin than did poorer learners. Better learners also engaged in more goal‐directed navigation than poorer learners. Case studies of two better and two poorer learners further illustrate how evaluation processes contributed to navigation decisions. Findings suggest that multiple‐source comprehension is a dynamic process that involves interplay among sense‐making, monitoring, and evaluation processes, all of which promote strategic reading.
Meniscus maturation in the swine model: changes occurring along with anterior to posterior and medial to lateral aspect during growth

The meniscus plays important roles in knee function and mechanics and is characterized by a heterogeneous matrix composition. The changes in meniscus vascularization observed during growth suggest that the tissue‐specific composition may be the result of a maturation process. This study has the aim to characterize the structural and biochemical variations that occur in the swine meniscus with age. To this purpose, menisci were collected from young and adult pigs and divided into different zones. In study 1, both lateral and medial menisci were divided into the anterior horn, the body and the posterior horn for the evaluation of glycosaminoglycans (GAGs), collagen 1 and 2 content. In study 2, the menisci were sectioned into the inner, the intermediate and the outer zones to determine the variations in the cell phenotype along with the inner–outer direction, through gene expression analysis. According to the results, the swine meniscus is characterized by an increasing enrichment in the cartilaginous component with age, with an increasing deposition in the anterior horn (GAGs and collagen 2; P < 0.01 both); moreover, this cartilaginous matrix strongly increases in the inner avascular and intermediate zone, as a consequence of a specific differentiation of meniscal cells towards a cartilaginous phenotype (collagen 2, P < 0.01). The obtained data add new information on the changes that accompany meniscus maturation, suggesting a specific response of meniscal cells to the regional mechanical stimuli in the knee joint.
Fazlur Rahman and the Search for Authentic Islamic Education: A Critical Appreciation

Abstract The article provides a critical appreciation of the educational thought of Fazlur Rahman, a major figure in the 20th‐century Muslim modernist trend. By situating his life and work in the history of Muslim reform, the article brings into relief distinctive elements of his intellectual project. Connections between Fazlur Rahman’s philosophy of education and his proposal for the Qur’an’s reinterpretation are outlined and assessed. In this context, his ideas about the location of meaning, role of tradition, and causes of Muslim decline which underpin his “double movement” theory are investigated. The article notes the wide‐ranging impact of Fazlur Rahman’s interpretive approach on educational and reformist thought in many Muslim contexts. Finally, Fazlur Rahman’s theory and its underlying assumptions are assessed, bringing out in particular the tension between his scholarly and reformist aims.
Circadian Clock, Cell Division, and Cancer: From Molecules to Organism

As a response to environmental changes driven by the Earth’s axial rotation, most organisms evolved an internal biological timer—the so called circadian clock—which regulates physiology and behavior in a rhythmic fashion. Emerging evidence suggests an intimate interplay between the circadian clock and another fundamental rhythmic process, the cell cycle. However, the precise mechanisms of this connection are not fully understood. Disruption of circadian rhythms has a profound impact on cell division and cancer development and, vice versa, malignant transformation causes disturbances of the circadian clock. Conventional knowledge attributes tumor suppressor properties to the circadian clock. However, this implication might be context-dependent, since, under certain conditions, the clock can also promote tumorigenesis. Therefore, a better understanding of the molecular links regulating the physiological balance between the two cycles will have potential significance for the treatment of cancer and associated disorders.
Effect of sire and extender on sperm motility and share of live or dead sperm in bulls’ fresh ejaculate and in AI doses after thawing

Abstract. The objectives were to evaluate the effects of sire and content of fresh or ionised egg yolk in extenders on sperm motility and share of live and dead sperm in collected ejaculate, in thawed artificial insemination (AI) doses, and during thermodynamic testing compared to extenders not containing egg yolk. Ejaculates were collected once a week from 4 Holstein bulls. Each of the 20 ejaculate samples from each bull was diluted with 4 different extenders. AndroMed and Bioxcell (no egg yolk) and Triladyl and Optidyl (fresh, ionised egg yolk) were used. A total of 640 AI doses were analysed. The volume of samples, sperm concentration, and percentage of motile spermatozoa were evaluated after collection, as was sperm motility after thawing of AI doses and during thermodynamic testing. Percentages of live and dead sperm were also evaluated. The data set was analysed using SAS/STAT 9.1 (SAS Institute Inc., Cary, NC, USA). The results confirmed significant (P
An equality of condition framework for user involvement in mental health policy and planning: evidence from participatory action research

Discussions about user involvement in the mental health services tend to throw up four major areas of concern: the capacity of service users to participate, their lack of participation skills, the need for a positive organisational culture and the need for arenas of participation. This article presents evidence from participatory action research with Irish mental health service users which explored how they could more equally participate in advisory committees. Participants identified barriers to their equal participation due to unequal cultural, physical, mental and economic resources, time, power, ‘stigma’(prejudice) and lack of respect for their experiential knowledge and emotional expression. These barriers fall within the ‘equality of condition framework’ developed by Baker and colleagues. Enabling equal user involvement in strategic decision‐making requires more than arenas of participation – it requires comprehensively addressing service users’ structural disadvantages throughout the process of involvement.
Gene location and bacterial sequence divergence.

Previous comparison of a relatively small set of homologous genes from Escherichia coli and Salmonella typhimurium revealed that genes nearer to the origin of replication had substitution rates lower than genes closer to the replication terminus. The recently completed sequences of numerous bacterial genomes have allowed us to test whether this effect of distance from the replication origin on substitution rates, as observed for the E. coli-S. typhimurium comparison, is a general feature of bacterial genomes. Extending the analysis to all 3,000 E. coli-S. typhimurium homologs confirmed the significant association between chromosomal position and synonymous site divergence. However, the effect, though still significant, is not as dramatic as originally thought. A similar association between relative chromosomal location and synonymous substitution rate was detected in the majority of other bacterial species comparisons within alpha- and gamma- Proteobacteria, and Firmicutes but was absent in Chlamydiales. The opposite trend, i.e., a decrease in synonymous divergence with distance from the replication origin, was detected in Mycobacteria. Analysis of the patterns of nucleotide substitutions revealed that the distance effect is not affected by gene orientation and is mainly caused by an increase in rates of transversions, suggesting that this effect may not be caused by recombinational repair or biased gene conversion, as originally suggested.
Transcutaneous electrical nerve stimulation and conditioned pain modulation influence the perception of pain in humans

Research in animal models suggests that transcutaneous electrical nerve stimulation (TENS) and conditioned pain modulation (CPM) produce analgesia via two different supraspinal pathways. No known studies have examined whether TENS and CPM applied simultaneously in human subjects will enhance the analgesic effect of either treatment alone. The purpose of the current study was to investigate whether the simultaneous application of TENS and CPM will enhance the analgesic effect of that produced by either treatment alone.
Study recommender system in semantic web mining-based: an updated model version

Resumen─ Se propone una version actualizada del modelo de Sistema Recomendador de Oportunidades de Estudio (SROE), el cual esta soportado por tecnologia y recursos metodologicos relacionados con la mineria de datos y la Web semantica; en particular, con esta propuesta se intenta mejorar la version preliminar del SROE, que se ha venido desarrollando en base a la sinergia que brindan la tecnologia semantica (ontologias) y los agentes inteligentes. A partir de un cuidadoso analisis de la literatura actual, se exploran recursos novedosos y experiencias efectivas para dominios similares, introducidos en investigaciones recientes, para actualizar la version del modelo formulado en trabajos previos, re-disenado tecnicamente para ofrecer opciones de estudios a los aspirantes a ingresar a las instituciones universitarias en Venezuela.