Miracle-dz/UniFAR-FTUs huggingface dataset:
A Comparison of Patient-Reported Outcome Measures Following Different Treatment Approaches for Adolescents with Severe Idiopathic Scoliosis: A Systematic Review

Adolescent idiopathic scoliosis (AIS) is a three-dimensional deformity of the spine which is usually not symptomatic and which can progress during growth and cause a surface deformity. In adulthood, if the final spinal curvature surpasses a certain critical threshold, the risk of health problems and curve progression is increased. Although surgery is usually recommended for curvatures exceeding 40° to 50° to stop curvature progression, recent reviews have shed some light on the long-term complications of such surgery and to the lack of evidence for such complicated procedures within the scientific literature. Furthermore, a number of patients are very fearful of having surgery and refuse this option or live in countries where specialist scoliosis surgery is not available. Other patients may be unable to afford the cost of specialist scoliosis surgery. For these patients the only choice is an alternative non-surgical treatment option. To examine the impact of different management options in patients with severe AIS, with a focus on trunk balance, progression of scoliosis, cosmetic issues, quality of life, disability, psychological issues, back pain, and adverse effects, at both the short-term (a few months) and the long-term (over 20 years). We searched CENTRAL, MEDLINE, EMBASE, CINHAL and two other databases up to January 2016 with no language limitations. We also checked the reference lists of relevant articles and conducted an extensive hand search of the grey literature. We searched for randomised controlled trials as well as prospective and retrospective controlled trials comparing spinal fusion surgery with no treatment or conservative treatment in AIS patients with a Cobb angle greater than 40°. We did not identify any evidence of superiority of effectiveness of operative compared to nonoperative interventions for patients with severe AIS. Within the present literature there is no clear evidence to suggest that a specific type of treatment is superior to other types of treatment.
The role of autonomy–connectedness in depression and anxiety

The relationship between autonomy–connectedness, and depression and anxiety was investigated in 94 primary mental health care patients and 95 psychology students. All participants completed the Autonomy–Connectedness Scale–30 (ACS‐30), the Beck Depression Inventory (BDI), and the Symptom Checklist–90 (SCL‐90). Results indicated that the primary mental health care group compared with the control group scored lower in Self‐Awareness and Capacity for Managing New Situations, and higher in Sensitivity to Others. Women compared with men had higher levels of self‐reported Sensitivity to Others. Regression analyses showed that both (low) Self‐Awareness and (high) Sensitivity to Others predicted depression, as well as anxiety; also, (low) educational level had predictive value. These results indicate that low autonomy–connectedness might be a risk factor for depression and anxiety. Depression and Anxiety 23:274–280, 2006. © 2006 Wiley‐Liss, Inc.
Blood Pressure and Hypertension in Adults Permanently Living at High Altitude: A Systematic Review and Meta-Analysis.

Aryal, Nirmal, Mark Weatherall, Yadav Kumar Deo Bhatta, and Stewart Mann. Blood pressure and hypertension in adults permanently living at high altitude: a systematic review and meta-analysis. High Alt Med Biol. 17:185-193, 2016. -The objective of this study was to estimate the associations between altitude and mean blood pressure (BP) (or prevalence of hypertension [HT]) in adults who live permanently at high altitude. A literature search was conducted in December 2014 using PubMed, Scopus, and OvidSP (MedLine and EMBASE) databases to identify relevant observational studies. Inclusion criteria were reports of studies in populations permanently living at an altitude of ≥2400 m and in those 18 years or older. Meta-regression was used to estimate the association between average BP and HT and altitude. We identified 3375 articles and inclusion criteria were met for 21 reports, which included a total of 40,854 participants. Random-effects meta-regression estimated that for every 1000 m elevation the average systolic BP (SBP) (95% confidence interval [CI]) increased by 17 mmHg (0.2 to 33.8), p = 0.05 and diastolic BP (DBP) by 9.5 mmHg (0.6 to 18.4), p = 0.04 in participants with Tibetan origin. By contrast, in participants with non-Tibetan origin, average SBP decreased by 5.9 mmHg (-19.1 to 7.3), p = 0.38 and DBP by 4 mmHg (-13 to 5), p = 0.38. The odds ratios (95% CI) for the proportion of participants with HT per 1000 m increment in the altitude were 2.01 (0.37 to 11.02), p = 0.446 and 4.05 (0.07 to 244.69), p = 0.489 for Tibetan and non-Tibetan participants, respectively. Sensitivity analysis excluding two studies with older participants (≥60 years) reversed the direction of this effect in non-Tibetans with odds ratio (95% CI) of 0.10 (0.004 to 2.22) per 1000 m, p = 0.143. Overall, this review suggests weak association between BP and altitude in Tibetan origin populations.
A Data-Based Model to Predict Postsecondary Educational Attainment of Low-Socioeconomic-Status Students

The National Educational Longitudinal Study database was used to examine the educational development of students of low socioeconomic status (SES). A path analysis was conducted to determine the effects of student background, psychological, and behavioral variables on postsecondary educational attainment of low-SES students. The results show that high school math scores were the most powerful predictor of postsec-ondary educational attainment, followed by effects of academic expectations, locus of control, reading scores, problem behavior, and classroom behavior. Implications for school counselors are discussed.
Endometrial Samples From Postmenopausal Women: A Proposal for Adequacy Criteria

Approximately 75% of endometrial cancer occurs in women older than 55 yr of age. Postmenopausal bleeding is often considered endometrial cancer until proven otherwise. One diagnostic challenge is that endometrial biopsy or curettage generally yields limited samples from elderly patients. There are no well-defined and unified diagnostic criteria for adequacy of endometrial samples. Pathologists who consider any sample including those lacking endometrial tissue as “adequate” run the risk of rendering false-negative reports; on the contrary, pathologists requiring ample endometrial glands along with stroma tend to designate a greater number of samples as “inadequate,” leading to unnecessary follow-up. We undertook a quantitative study of 1768 endometrial samples from women aged 60 yr and older aiming to propose validated adequacy criteria for diagnosing or excluding malignancy. Using repeat-procedure outcomes as reference, we found that samples exceeding 10 endometrial strips demonstrated high negative predictive value close to 100%. Such samples can be scant, yet appear to be sufficient in excluding malignant conditions. When tissue diminished to <10 strips, negative predictive value dropped significantly to 81%. The risk of undersampled malignancy rose to 19%. Among 274 malignant cases, only 4 cases yielded limited tissue yet >10 strips. In conclusion, we propose 10 endometrial strips as the minimum for adequate samples from postmenopausal women. Applying such validated adequacy criteria will greatly reduce false-negative errors and avoid unnecessary procedures while ultimately improving diagnostic accuracy. Our criteria may serve as a reference point in unifying the pathology community on this important and challenging topic.
Gender Markedness of Language

Three experiments investigated how grammatical gender and gender stereotypicality influence the way person information is mentally represented. Participants read sentences about social groups denoted by nouns with different grammatical gender and stereotypicality. A following sentence contained a reference to the social group that qualified the group members as female, male, or neither one. Experiment 1 tested grammatically masculine nouns; Experiment 2 tested gender-balanced forms, composed of the masculine and the feminine or neither one; and Experiment 3 tested nouns without gender inflection. Stereotypicality varied within studies. Second sentence reading times differed depending on the fit between grammatical gender and stereotypicality of the first sentence’s subject and the subsequent information’s gender-relatedness. Both grammatical gender and stereotypicality contribute biological gender information to mentally represented person information. Strong grammatical input may override stereotypicality’s influence. The feminine’s influence seems to be weaker than the masculine’s. Results are discussed in the framework of the scenario mapping and focus approach.
From bottom to top in higher education: women’s experiences and visions in different parts of the world – a summary

Presents a summary of information taken from the second conference on gender equality in higher education at the University of Zurich, Switzerland, September 2000. Outlines the proceeding papers stating that they give an overview of gender equality across five continents. Gives a brief overview of each paper and summarizes the findings of the conference as “women in higher education all over the world – highly socially and cultural differentiated but equally positioned”.
Mortality for certain diseases in areas with high levels of arsenic in drinking water.

Blackfoot disease was prevalent in a limited area on the southwest coast of Taiwan, where artesian well water containing arsenic (median = 0.78 ppm arsenic) had been used for many years. Previous studies of arsenic exposure in the blackfoot disease endemic area have been focused on malignant tumors. We, therefore, conducted this study to analyze mortality of all death causes in blackfoot disease endemic areas and to determine other neglected cancers or noncancer diseases related to artesian well water containing high levels of arsenic. We calculated standardized mortality ratios for cancer and noncancer diseases, by sex, during the period from 1971 to 1994 and compared them to the local reference group (i.e, Chiayi-Tainan County) and the national reference group (i.e., Taiwan population). The results revealed marked standardized mortality ratio differences for the 2 reference groups. Greater mortality was found for males and females with bladder, kidney, skin, lung, nasal-cavity, bone, liver, larynx, colon, and stomach cancers, as well as lymphoma than in the local reference population. With respect to noncancer diseases, we found greater mortality for males and females who had vascular disease, ischemic heart disease, diabetes mellitus, and bronchitis than in the local reference group. Mortalities for other diseases--including rectal cancer, cerebrovascular disease, and other diseases--were higher among cases than the local reference group. Our results indicated that the hazardous effect of arsenic is systemic. Diseases related to arsenic exposure included those reported previously by other investigators, as well as diseases reported in the present study.
Conflict between learners’ beliefs and actions: speaking in the classroom

Based on sociocultural and contextual perspectives, this study examines how Japanese language learners perceive a conflict between their beliefs and actions when speaking the target language in the classroom context, and how these learners change their beliefs or actions to overcome the conflict. Data were collected during a second-year level Japanese language course at an Australian university for one semester using multiple instruments (diary writing, interviews, and classroom observation and recording). The data were analysed qualitatively using content analysis. The study found that the learners had two different beliefs, which triggered a conflict between one of their beliefs and their actions. This conflict frustrated them. The learners developed their confidence, restructured their beliefs and actions, and solved the conflict to speak Japanese more frequently in the class.
Individual and School Predictors of Middle School Aggression

Hierarchical linear modeling is used to assess individual student, family, and school predictors of aggression in 111,662 students in sixth, seventh, and eighth grades. Nine measures of problem-solving strategies, quality of family and peer interaction, and perceptions of school climate are analyzed at the individual student level. Eight measures of school climate are included in the analysis at the school level. Aggression is operationalized with student self-report of the previous 6-month frequency of hitting others, being mean to others, and getting into a fight. At the level of the individual student, measures of problem solving were most strongly predictive of aggression. Inclusion of students in policy and rule processes, cultural sensitivity education, and teaching that emphasizes understanding over memorization were significant predictors of aggression at the school level. The potential for abatement of student aggression across individual and school levels offers opportunities for further testing of interventions for the child and the school.
Blood lactate recovery and respiratory responses during diagonal skiing of variable intensity

Abstract The aims of the study were to investigate blood lactate recovery and respiratory variables during diagonal skiing of variable intensity in skiers at different performance levels. Twelve male cross-country skiers classified as elite (n=6; [Vdot]O2max=73±3 ml · kg−1 · min−1) or moderately trained (n=6; [Vdot]O2max=61±5 ml · kg−1 · min−1) performed a 48-min variable intensity protocol on a treadmill using the diagonal stride technique on roller skis, alternating between 3 min at 90% and 6 min at 70% of [Vdot]O2max. None of the moderately trained skiers were able to complete the variable intensity protocol and there was a difference in time to exhaustion between the two groups (elite: 45.0±7.3 min; moderately trained: 31.4±10.4 min) (P<0.05). The elite skiers had lower blood lactate concentrations and higher blood base excess concentrations at all 70% workloads than the moderately trained skiers (all P<0.05). In contrast, [Vdot] E/[Vdot]O2 and [Vdot] E/[Vdot]CO2 at the 70% [Vdot]O2max workloads decreased independently of group (P<0.05). Partial correlations showed that [Vdot]O2max was related to blood lactate at the first and second intervals at 70% of [Vdot]O2max (r=−0.81 and r=−0.82; both P<0.01) but not to [Vdot] E/[Vdot]O2, [Vdot] E/[Vdot]CO2 or the respiratory exchange ratio. Our results demonstrate that during diagonal skiing of variable intensity, (1) elite skiers have superior blood lactate recovery compared with moderately trained skiers, who did not show any lactate recovery at 70% of [Vdot]O2max, suggesting it is an important characteristic for performance; and (2) the decreases in respiratory exchange ratio, [Vdot] E/[Vdot]O2, and [Vdot] E/[Vdot]CO2 do not differ between elite and moderately trained skiers.
User‐oriented mental health reform in Sweden: featuring ‘professional friendship’

In developing new forms for society‐based support for mental health service users, authorities implemented a service in Sweden, called Personligt ombud (PO), with the assignment to support service users exercising their rights. The aim of this article is to describe what service users find to be significant features of their working relationships with their PO. Using a phenomenological approach, 23 users were interviewed sharing their experiences of their PO. The results show that service users describe their relationships with the PO as a ‘professional friendship’. The friendship‐like feature refers to reciprocity in sharing life experiences and forming a trustful relationship in which professional assistance can be offered, promoting well‐being and recovery. Conclusions are that the PO provides a service that calls for re‐interpretation of professional and user roles, where both give and receive.
Adverse events associated with pyrazinamide and levofloxacin in the treatment of latent multidrug-resistant tuberculosis.

BACKGROUND The current Canadian and US guidelines for the treatment of multidrug-resistant latent tuberculosis infection advocate the use of pyrazinamide and a fluoroquinolone as a first-line treatment option. However, there is very little information in the literature that describes the use of these agents together. This case series describes the probable association between multiple adverse events and the use of pyrazinamide and levofloxacin in the treatment of individuals with suspected latent multidrug-resistant tuberculosis infection. METHODS We studied a case series of 17 individuals with suspected latent multidrug-resistant tuberculosis infection in Hamilton, Ont. , who were being treated with pyrazinamide and levofloxacin. The Naranjo scale was used to assess patients for musculoskeletal, central nervous system, gastrointestinal and dermatological adverse events. Hepatocellular events were assessed and defined using criteria established by the Council for International Organizations of Medical Sciences. Laboratory abnormalities and adverse events that were documented during combination drug therapy were evaluated to determine the likelihood of an association. RESULTS Fourteen individuals developed musculoskeletal adverse effects (11 were deemed to be probably related to combination therapy). There were 8 reports of central nervous system effects (5 of which were assessed as being probably associated with therapy). Hyperuricemia and gastrointestinal and dermatological effects were also common; the use of pyrazinamide and levofloxacin was believed to be probably responsible for the emergence of these adverse effects. There were 5 cases of hepatocellular injury. Therapy was discontinued in all individuals. INTERPRETATION The combination of pyrazinamide and levofloxacin appears to be a poorly tolerated regimen. The mechanism of a possible interaction is not yet understood. Given the severity of some of the adverse events, a better understanding of dosing and clearer guidelines for monitoring therapy are imperative if these drugs are to be prescribed together.
International Conference on Education and Educational Psychology (ICEEPSY 2011) Knowing how to learn and how to teach motivation: Contributions from Self-Regulation of Motivation to more a effective learning

Students can monitor and regulate their motivation to learn – self-regulation of motivation (SRM) – and this process has a positive impact on achievement. In this paper, we analyze the SRM process with middle school students, through three studies. On the first, it will be evaluated determinants of SRM (e.g. expectancies, goals and values) and SRM strategies. In the second, we will analyze through two focus group teacher’s perceptions about the most effective educational practices to promote SRM. From these, in the third study, will be designed a classroom program directed to the stimulation and development of strategies for
Determining the benefits of transcranial direct current stimulation on functional upper limb movement in chronic stroke

Transcranial direct current stimulation (tDCS) has been proposed as a tool to enhance stroke rehabilitation; however, evidence to support its use is lacking. The aim of this study was to investigate the effects of anodal and cathodal tDCS on upper limb function in chronic stroke patients. Twenty five participants were allocated to receive 20 min of 1 mA of anodal, cathodal or sham cortical stimulation in a random, counterbalanced order. Patients and assessors were blinded to the intervention at each time point. The primary outcome was upper limb performance as measured by the Jebsen Taylor Test of Hand Function (total score, fine motor subtest score and gross motor subtest score) as well as grip strength. Each outcome was assessed at baseline and at the conclusion of each intervention in both upper limbs. Neither anodal nor cathodal stimulation resulted in statistically significantly improved upper limb performance on any of the measured tasks compared with sham stimulation (P>0.05). When the data were analysed according to disability, participants with moderate/severe disability showed significantly improved gross motor function following cathodal stimulation compared with sham (P=0.014). However, this was accompanied by decreased key grip strength in the unaffected hand (P=0.003). We are unable to endorse the use of anodal and cathodal tDCS in the management of upper limb dysfunction in chronic stroke patients. Although there appears to be more potential for the use of cathodal stimulation in patients with severe disability, the effects were small and must be considered with caution as they were accompanied by unanticipated effects in the unaffected upper limb.
Epstein-Barr Virus Latent Membrane Protein 2a (Lmp2a) Employs the Slp-65 Signaling Module

In latently infected B lymphocytes, the Epstein-Barr virus (EBV) suppresses signal transduction from the antigen receptor through expression of the integral latent membrane protein 2A (LMP2A). At the same time, LMP2A triggers B cell survival by a yet uncharacterized maintenance signal that is normally provided by the antigen receptor. The molecular mechanisms are unknown as LMP2A-regulated signaling cascades have not been described so far. Using a novel mouse model we have identified the intracellular adaptor protein Src homology 2 (SH2) domain–containing leukocyte protein (SLP)-65 as a critical downstream effector of LMP2A in vivo. Biochemical analysis of the underlying signaling pathways revealed that EBV infection causes constitutive tyrosine phosphorylation of one of the two SLP-65 isoforms and complex formation between SLP-65 and the protooncoprotein CrkL (CT10 regulator of kinase like). This leads to antigen receptor-independent phosphorylation of Cbl (Casitas B lineage lymphoma) and C3G. In contrast, phospholipase C-γ2 (PLC-γ2) activation is completely blocked. Our data show that in order to establish a latent EBV infection, LMP2A selectively activates or represses SLP-65–regulated signaling pathways.