Miracle-dz/UniFAR-FTUs huggingface dataset:
Risk Factors for Falls in Hospital In-Patients: A Prospective Nested Case Control Study

Background: Patient falls are considered a challenge to the patient’s safety in hospitals, which, in addition to increasing the length of stay and costs, may also result in severe injuries or even the death of the patient. This study aims to investigate the associations between risk factors among fallers in comparison with the control group. Methods: A prospective nested case control study was performed on 185 patients who fell and 1141 controls were matched with the patients at risk of fall in the same ward and during the same time. This study was conducted in a university educational hospital in Tehran with 800 beds during a 9-month period. The data included demographics, comorbidities, admission details, types of medication, clinical conditions, and activities before or during the fall. The data was collected from clinical records, hospital information system, error reporting system and observations, and the interviews with the fallers, their families and care givers (physicians, nurses, etc). Data analysis was conducted through time-based matching using a multi-level analysis. Results: In a multilevel model including patient-related, medication, and care-related variables, the factors that were significantly associated with an increased risk of patient falls included: longer length of stay (odds ratio [OR] = 1.01; CI=0.32 to 0.73), using chemotherapy drugs, sedatives, anticonvulsants, benzodiazepines, and angiotensin-converting enzyme (ACE) inhibitors, visual acuity (OR=6.93; CI=4.22 to 11.38), balance condition (OR= 6.41; CI=4.51 to 9.11), manual transfer aid (OR=8.47; CI=5.65 to 12.69), urinary incontinence (OR= 8.47, CI= 5.65 to 12.69), and cancer (OR=2.86, CI=1.84-4.44). These factors were found to be associating with more odds for a falling accident among patients. Several characteristics such as fall history (OR=0.48; CI= 1.003 to 1.02), poly-pharmacy (OR=1.37, CI=00.85 to 2.2), stroke (OR=0.94, CI= 0.44 to 2.02), and nurse to patient ratio (incidence rate ratio=1.01, CI=0.01 to 0.03) were not significantly associated with falling in hospitals. Conclusion: It seems that a combination of both patient-related factors and history of medication should be considered. Moreover, modifiable clinical characteristics of patients such as vision improvement, provision of manual transfer aid, diabetes control, regular toilet program, and drug modification should be considered during the formulation of interventions.
Speech Act Theory as an Evaluation Tool for Human-Agent Communication

Effective communication in task-oriented situations requires high-level interactions. For human–agent collaboration, tasks need to be coordinated in a way that ensures mutual understanding. Speech Act Theory (SAT) aims to understand how utterances can be used to achieve actions. SAT consists of three components: locutionary act, illocutionary act, and perlocutionary act. This paper evaluates the agent’s verbal communication while collaborating with humans. SAT was used to anatomize the structure of the agent’s speech acts (locutionary acts), the agent’s intention behind the speech acts (illocutionary acts), and the effects on the human’s mental state (perlocutionary acts). Moreover, this paper studies the impact of human perceptions of the agent’s speech acts on the perception of collaborative performance with the agent.
The young and the city: crowdsourcing urban awareness in a developing country

We present a crowdsourcing study that investigates impressions of urban spaces by young inhabitants in a city in the developing world. Our goal is to obtain collective perceptions from the actual inhabitants of the city under study, and more specifically youth (16-18 year-old) about issues like danger, accessibility, and dirtiness. We collect over 9000 judgments for 102 photos of outdoor urban spaces in a city in Central Mexico using standard scales in social sciences. We present reliability and response analyses and demonstrate how local youth can provide relevant urban insights in a crowdsourcing setting.
State Machine Replication for the Masses with BFT-SMART

The last fifteen years have seen an impressive amount of work on protocols for Byzantine fault-tolerant (BFT) state machine replication (SMR). However, there is still a need for practical and reliable software libraries implementing this technique. BFT-SMART is an open-source Java-based library implementing robust BFT state machine replication. Some of the key features of this library that distinguishes it from similar works (e.g., PBFT and UpRight) are improved reliability, modularity as a first-class property, multicore-awareness, reconfiguration support and a flexible programming interface. When compared to other SMR libraries, BFT-SMART achieves better performance and is able to withstand a number of real-world faults that previous implementations cannot.
Covert Communication Over Noisy Channels: A Resolvability Perspective

We consider the situation in which a transmitter attempts to communicate reliably over a discrete memoryless channel, while simultaneously ensuring covertness (low probability of detection) with respect to a warden, who observes the signals through another discrete memoryless channel. We develop a coding scheme based on the principle of channel resolvability, which generalizes and extends prior work in several directions. First, it shows that irrespective of the quality of the channels, it is possible to communicate on the order of √n reliable and covert bits over n channel uses if the transmitter and the receiver share on the order of √n key bits. This improves upon earlier results requiring on the order of √n log n key bits. Second, it proves that if the receiver's channel is better than the warden's channel in a sense that we make precise, it is possible to communicate on the order of √n reliable and covert bits over n channel uses without a secret key. This generalizes earlier results established for binary symmetric channels. We also identify the fundamental limits of covert and secret communications in terms of the optimal asymptotic scaling of the message size and key size, and we extend the analysis to Gaussian channels. The main technical problem that we address is how to develop concentration inequalities for low-weight sequences. The crux of our approach is to define suitably modified typical sets that are amenable to concentration inequalities.
Inflammation and infections in unreported chronic obstructive pulmonary disease exacerbations

Purpose: COPD patients often do not report acute exacerbations to healthcare providers – unreported exacerbations. It is not known whether variances in symptoms, airway obstruction, aetiology and inflammatory responses account for differences in reporting of COPD exacerbations. The aims of the study were to compare symptoms, lung function changes, aetiology and inflammatory markers between exacerbations that were reported to healthcare providers or treated, with those that were unreported and untreated. Patients and methods: We recruited a cohort of COPD patients and collected clinical data and blood and airway samples when stable and during acute exacerbations. Virological and bacterial analyses were carried out and inflammatory markers measured. Results: We found no differences in symptoms, lung function, incidence of infection and inflammatory markers between reported and unreported exacerbations. Subjects who reported all exacerbations had higher BODE scores, lower FEV1 and more exacerbations compared with those who did not. Conclusion: The failure to report exacerbations is not related to the severity, aetiology or inflammatory profile of the exacerbation. Patients with less severe COPD and less frequent exacerbations are less likely to report exacerbations. The decision to report an exacerbation is not an objective marker of exacerbation severity and therefore studies that do not count unreported exacerbations will underestimate the frequency of clinically significant exacerbations. A better understanding of the factors that determine non-reporting of exacerbations is required to improve exacerbation reporting. Trial registration: ClinicalTrials.gov Identifier: NCT01376830. Registered June 17, 2011
Cointegration and Consumption Risks in Asset Returns

We argue that the cointegrating relation between dividends and consumption, a measure of long-run consumption risks, is a key determinant of risk premia at all investment horizons. As the investment horizon increases, transitory risks disappear, and the asset's beta is dominated by long-run consumption risks. We show that the return betas, derived from the cointegration-based VAR (EC-VAR) model, successfully account for the cross-sectional variation in equity returns at both short and long horizons; however, this is not the case when the cointegrating restriction is ignored. Our evidence highlights the importance of cointegration-based long-run consumption risks for financial markets.
Integrated analysis of two-lncRNA signature as a potential prognostic biomarker in cervical cancer: a study based on public database

Background Cervical cancer (CC) is a common gynecological malignancy in women worldwide. Evidence suggests that long non-coding RNAs (lncRNAs) can be used as biomarkers in patients with CC. However, prognostic biomarkers for CC are still lacking. The aim of our study was to find lncRNA biomarkers which are able to predict prognosis in CC based on the data from The Cancer Genome Atlas (TCGA). Methods The patients were divided into three groups according to FIGO stage. Differentially expressed lncRNAs were identified in CC tissue compared to adjacent normal tissues based on a fold change >2 and <0.5 at P < 0.05 for up- and downregulated lncRNA, respectively. The relationship between survival outcome and lncRNA expression was assessed with univariate and multivariate Cox proportional hazards regression analysis. We constructed a risk score as a method to evaluate prognosis. We used receiver operating characteristic (ROC) curve and the area under curve (AUC) analyses to assess the diagnostic value of a two-lncRNA signature. We detected the expression levels of the two lncRNAs in 31 pairs of newly diagnosed CC specimens and paired adjacent non-cancerous tissue specimens, and also in CC cell lines. Finally, the results were statistically compared using t-tests. Results In total, 289 RNA sequencing profiles and accompanying clinical data were obtained. We identified 49 differentially expressed lncRNAs, of which two related to overall survival (OS) in CC patients. These two lncRNAs (ILF3-AS1 and RASA4CP) were found together as a single prognostic signature. Meanwhile, the prognosis of patients with low-risk CC was better and positively correlated with OS (P < 0.001). Further analysis showed that the combined two-lncRNA expression signature could be used as an independent biomarker to evaluate the prognosis in CC. qRT-PCR results were consistent with TCGA, confirming downregulated expression of both lncRNAs. Furthermore, upon ROC curve analysis, the AUC of the combined lncRNAs was greater than that of the single lncRNAs alone (0.723 vs 0.704 and 0.685), respectively; P < 0.05. Conclusions Our study showed that the two-lncRNA signature of ILF3-AS1 and RASA4CP can be used as an independent biomarker for the prognosis of CC, based on bioinformatic analysis.
Hepatoprotective Activity of Elephantopus scaber on Alcohol-Induced Liver Damage in Mice

Elephantopus scaber has been traditionally used as liver tonic. However, the protective effect of E. scaber on ethanol-induced liver damage is still unclear. In this study, we have compared the in vivo hepatoprotective effect of E. scaber with Phyllanthus niruri on the ethanol-induced liver damage in mice. The total phenolic and total flavanoid content of E. scaber ethanol extract were determined in this study. Accelerating serum biochemical profiles (including AST, ALT, ALP, triglyceride, and total bilirubin) associated with fat drop and necrotic body in the liver section were observed in the mice treated with ethanol. Low concentration of E. scaber was able to reduce serum biochemical profiles and the fat accumulation in the liver. Furthermore, high concentration of E. scaber and positive control P. niruri were able to revert the liver damage, which is comparable to the normal control. Added to this, E. scaber did not possess any oral acute toxicity on mice. These results suggest the potential effect of this extract as a hepatoprotective agent towards-ethanol induced liver damage without any oral acute toxicity effect. These activities might be contributed, or at least in part, by its high total phenolic and flavonoid contents.
EFFECT OF DIFFERENT DIETARY LINOLEIC ACID TO LINOLENIC ACID RATIOS ON SOME PRODUCTIVE , IMMUNOLOGICAL AND PHYSIOLOGICAL TRAITS OF DANDARAWY CHICKS

This study was carried out to determine the effects of dietary linoleic acid to linolenic acid ratio on productive, immunological and physiological performance of Dandarawy chicks (Egyptian developed strain). A total number of 450 oneday old unsexed chicks were randomly equally divided, into five experimental groups of three replicates (30 chicks, each). The experimental chicks were assigned to 1 of 5 diets that had linoleic acid (LA) to linolenic acid (LNA) ratios of 2:1, 4:1, 6:1, 8:1 and 10:1, respectively by changing the proportions of soybean and linseed oils. At the end of the 4 th week of age, chicks of each experimental group had been redivided into six replicates (three female replicates of 20 chicks each and three male replicates of 10 chicks each). The chicks of each experimental group continued on the same diet till the end of the study (18 weeks of age). The criteria studied were growth performance (at 4, 8 and 18 weeks of age), some blood immunological parameters (WBCs, RBCs, IgG, HB, IgM, and PCV %) at 8 and 18 weeks of age and immune response against sheep red blood cells (SRBC's), avian influenza (AVI), and Newcastle diseases (ND) titters at 18 weeks of age. Also, at the end of the experimental period, some blood constituents, including total lipids, triglyceride, cholesterol, LDL-cholesterol, total protein, albumin, globulin, as well as AST, ALT and alkaline phosphates enzymes were determined. Results obtained indicate that chicks received LA: LNA ratios of 4:1 and 6:1 in the diets had the highest live body weight, body weight gain and the best feed conversion at all tested ages. While, LA: LNA at the ratio of 6:1 (at 18 weeks of age), followed by 4:1 and 2:1 (at 8 weeks of age) showed positive immune functions than higher LA: LNA ratios of 8:1 and 10:1 in the diets. Results of serum metabolites revealed controversial trends, where LA: LNA ratios of 4:1 and 6:1 in the diets had a negative effects regarding serum total lipids, triglycerides, cholesterol and LDL-cholesterol, while, serum total protein, albumin and globulin were elevated with such levels. In conclusion, LA: LNA ratios of 4:1 and 6:1 in the diets of Dandarawy chicks are acceptable and recommended to improve the growth performance, physiological traits and immune response up to 18 weeks of age. Key Word: Linoleic Acid, Linolenic Acid, Immunological, Dandarawy.
Zinc Oxide Nanoparticles Obtained by Supercritical Antisolvent Precipitation for the Photocatalytic Degradation of Crystal Violet Dye

In this work, the synthesis of zinc oxide (ZnO) photocatalyst from thermal decomposition of zinc acetate (ZnAc) nanoparticles obtained by supercritical antisolvent (SAS) precipitation was investigated. The optimization of calcination conditions of the SAS ZnAc was carried out, studying the effect of temperature (in the range 300–600 °C) on the production of ZnO nanoparticles. In particular, it was demonstrated that the organic residues in ZnO and its particle size, thus the specific surface area, strongly affect the photocatalytic performances. SAS micronization of ZnAc produces regular nanoparticles with a mean diameter of about 54.5 ± 11.5 nm, whereas unprocessed ZnAc is characterized by very large crystals. The experimental results evidenced that ZnAc prepared by SAS process calcined at 500 °C showed a regular nanometric structure (mean diameter: 65.0 ± 14.5 nm) and was revealed to be the best choice for the photocatalytic removal of crystal violet dye (CV). In fact, the photocatalytic activity performances of ZnO nanoparticles prepared by this route were higher with respect to that of ZnO from unprocessed ZnAc calcined at 500 °C (which is characterized by irregular tetrapods with mean size 181.1 ± 65.5 nm). The optimized photocatalyst was able to assure the complete CV decolorization in 60 min of UV irradiation time and a mineralization degree higher than 90% after 120 min of treatment time.
Second-generation antipsychotic drugs and extrapyramidal side effects: a systematic review and meta-analysis of head-to-head comparisons.

OBJECTIVE While all second-generation antipsychotics (SGAs) are promoted for having a low risk of extrapyramidal side effects (EPS), clinical observations suggest differences between the various agents. Nevertheless, this question has never been examined in a systematic review and meta-analysis of head-to-head comparisons. METHODS We searched the register of the Cochrane schizophrenia group (last search May 2007), supplemented by MEDLINE (last search July 2009) for randomized, blinded studies comparing the following SGAs in the treatment of schizophrenia or related disorders: amisulpride, aripiprazole, clozapine, olanzapine, quetiapine, risperidone, sertindole, ziprasidone, and zotepine. At least 3 reviewers extracted the data independently. The primary outcome was "use of antiparkinson medication. " The results were combined in a meta-analysis. RESULTS We included 54 studies with 116 arms. Risperidone was associated with more use of antiparkinson medication than clozapine, olanzapine, quetiapine, and ziprasidone. Ziprasidone showed more use of antiparkinson medication than olanzapine and quetiapine and zotepine more than clozapine. There was no significant difference between amisulpride and its comparators (olanzapine, risperidone, or ziprasidone). Quetiapine showed significantly less use of antiparkinson medication than the 3 other SGAs it was compared with (olanzapine, risperidone, and ziprasidone). Scale-derived data (Barnes Akathisia Scale and Simpson Angus Scale) were limited. CONCLUSIONS Our meta-analysis demonstrates that there are differences between the SGAs in their ability to induce EPS that clinicians consider warrant treatment with antimuscarinic drugs. Even though the differences were relatively small, they might be important for individual patients and should be taken into account in drug choice.
Clinical characteristics of males with systemic lupus erythematosus (SLE) in an inception cohort of patients in Ghana

Summary Background Systemic Lupus Erythematosus (SLE) is said to be rare in Sub-Saharan Africa and even rarer in males worldwide. SLE is mostly considered a disease of women, though men may also be affected, and this may lead to a delay in diagnosis in men. The result is a greater burden of inflammation and subsequent organ damage over time. Method Data from the medical records of 13 male patients diagnosed with SLE at the Rheumatology Clinic of Korle- Bu Teaching Hospital between January 2014 and January 2017 was retrospectively analyzed. Results A total of 13 male patients out of a total of 134 SLE patients were included in our analysis. The mean age was 30.62 ± SD 8.47 years (range of 17 to 46 years). All of them (100%) presented with constitutional features. The most common ACR criteria observed was 61.5 % rash, 54.5 % oral ulcers, 92.3% arthritis, 61.5 % serositis and 38.5% renal involvement, 46.2 % CNS involvement. Looking at their serological profile, 91.7 % had a positive antinuclear antibody (ANA). 33.3 % had positive anti-dsDNA and 58.3 % extractable nuclear antigens. The mean duration from onset of symptoms to diagnosis was 21.31 months. Five patients were diagnosed with lupus nephritis, all at the time of diagnosis. There were no mortalities. Conclusion Male SLE patients in Ghana are comparable to other populations, with arthritis and constitutional features being predominant early features and lupus nephritis being the main early indicator of organ damage. This should warrant aggressive management in male patients. Funding None declared
Children's difficulties on starting infant school.

SUMMARY Two hundred and sixty London children in their first term at infant school were rated by their teachers on a scale covering a wide range of behaviour. Thirteen per cent of the sample were having general difficulty coping with school, and around 25% had difficulties with language, persistence with activities, and fine motor control. Boys had significantly more difficulties than girls, and children starting in January-had significantly more difficulties than those starting in September. A substantial minority of the children was still having difficulties eighteen months later. Several of these findings are replicated on data collected independently in Slough.
A General Approach to Service Deployment in Cloud Environments

The cloud computing landscape has recently developed into a spectrum of cloud architectures, leading to a broad range of management tools for similar operations but specialized for certain deployment scenarios. This both hinders the efficient reuse of algorithmic innovations within cloud management operations and increases the heterogeneity between different management systems. Our overarching goal is to overcome these problems by developing tools general enough to support the full range of popular architectures. In this contribution, we analyze commonalities in recently proposed cloud models (private clouds, multi-clouds, bursted clouds, federated clouds, etc.), and demonstrate how a key management functionality - service deployment - can be uniformly performed in all of these by a carefully designed system. The design of our service deployment framework is validated through a demonstration of how it can be used to deploy services, perform bursting and brokering, as well as mediate a cloud federation in the context of the OPTIMIS Toolkit.
Multi-source training and adaptation for generic speech recognition

In recent years there has been a considerable amount of work devoted to porting speech recognizers to new tasks. Recognition systems are usually tuned to a particular task and porting the system to a new task (or language) is both time-consuming and expensive. In this paper, issues in speechrecognition portability are addressedand in particular the developmentof generic models for speech recognition. Multi-source training techniques aimed at enhancing the genericity of some wide domain models are investigated. We show that multi-source training and adaptation can reduce the performance gap between task-independent and task-dependent acoustic models, and for some tasks even out-perform task-dependent acoustic models.
The effect of variable renewable energy sources on electricity price volatility: the case of the Iberian market

ABSTRACT The relationship between variable renewable energy supply (V-RES) and electricity price volatility is a controversial issue in the economic literature. In general, the literature has been inconclusive about the sign of the impact of installed capacity of these technologies on price volatility. This paper investigates the impact of V-RES on price volatility for the Iberian Market of Electricity (MIBEL), in the period ranging from 2010 to 2015. Using regression analysis and EGARCH models, we conclude that V-RES, and more specifically wind power supply, heightens price volatility. Likewise, greater intraday variability of V-RES also induces higher price volatility. Finally, following an analysis of the connection with the French market, we find that market coupling could help alleviate the sensitivity of price volatility to wind power supply variability.