Miracle-dz/UniFAR-FTUs huggingface dataset:
Kudzu (Pueraria montana) invasion doubles emissions of nitric oxide and increases ozone pollution

The nitrogen-fixing legume kudzu (Pueraria montana) is a widespread invasive plant in the southeastern United States with physiological traits that may lead to important impacts on ecosystems and the atmosphere. Its spread has the potential to raise ozone levels in the region by increasing nitric oxide (NO) emissions from soils as a consequence of increasing nitrogen (N) inputs and cycling in soils. We studied the effects of kudzu invasions on soils and trace N gas emissions at three sites in Madison County, Georgia in 2007 and used the results to model the effects of kudzu invasion on regional air quality. We found that rates of net N mineralization increased by up to 1,000%, and net nitrification increased by up to 500% in invaded soils in Georgia. Nitric oxide emissions from invaded soils were more than 100% higher (2.81 vs. 1.24 ng NO-N cm−2 h−1). We used the GEOS-Chem chemical transport model to evaluate the potential impact of kudzu invasion on regional atmospheric chemistry and air quality. In an extreme scenario, extensive kudzu invasion leads directly to an increase in the number of high ozone events (above 70 ppb) of up to 7 days each summer in some areas, up from 10 to 20 days in a control scenario with no kudzu invasion. These results establish a quantitative link between a biological invasion and ozone formation and suggest that in this extreme scenario, kudzu invasion can overcome some of the air quality benefits of legislative control.
From sharing to dividing: young children’s understanding of division

Children have particular difficulty with division problems, as compared to sharing problems. An inability to discriminate between the dividend, divisor and quotient might contribute to their difficulty with division. This study investigates whether young children (5–9 years) were able to discriminate between the divisor and quotient in simple division problems that were modeled for them. Children were presented with partitive and quotitive division problems in which the dividend was grouped either by the divisor or by the quotient. The children showed a very different pattern of results in the partitive and quotitive problems; they found it easier to identify the answer (quotient) when the dividend was grouped by the divisor in partitive problems and by the quotient in quotitive problems. It is argued that children rely on a schema of action of creating ‘portions’ when they first learn about division, and that the ‘portions’ produced by sharing are different in partitive and quotitive problems. We discuss this finding in terms of the importance of problem representation, children’s schemas of action and mental models.
Visible and Invisible Barriers to the Incorporation of Faculty of Color in Predominantly White Law Schools

Despite efforts to diversify faculty in predominantly White institutions, most law schools remain predominantly male and Caucasian. Based heavily on aspects of Law Professor Derrick Bell's work and research, the author, a lawyer by training, explores the extent to which limited institutional support in law school environments cripples the chances of faculty of color in their efforts to succeed. The author also points out the mechanisms that scholars of color in law schools have used in an effort to combat racial and gender discrimination.
Dermatofibrosarcoma protuberans treated at a single institution: a surgical disease with a high cure rate.

PURPOSE Dermatofibrosarcoma protuberans (DFSP) is a rare, low-grade, cutaneous sarcoma with autocrine overproduction of the platelet-derived growth factor (PDGF) beta-chain from gene rearrangement as a key pathogenetic factor, now susceptible of molecular-targeted therapy. The aim of this retrospective analysis was to explore the outcome of patients with primary or recurrent DFSP. PATIENTS AND METHODS Two hundred eighteen patients surgically treated at the Istituto Nazionale per lo studio e la cura dei Tumori (Milan, Italy) over 20 years were reviewed. Local relapse, distant metastasis, and survival were studied. RESULTS One hundred thirty-six patients (62.4%) presented with a primary DFSP, while 82 patients (37.6%) had a recurrent disease. In the primary group, margins were microscopically positive in 11.8%, while in the recurrent group they were positive in 14.6% (P =.613). In the primary group, patients undergoing re-excision after inadequate previous surgery had residual disease in 62% of cases. Reconstructive surgery was needed in 30%, significantly more frequently in patients with a recurrence or a head and neck tumor. The crude cumulative incidence of local relapses was 4% at 10 years, and 2% at 10 years for distant metastases. No significant difference was found between primary and recurrent patients, as well as between positive and negative margins. CONCLUSION This being one of the largest mono-institutional series of DFSP, we confirm that long-term outcome is excellent, in terms of both local and distant control, after a wide excision with negative margins. Reconstructive surgery is often needed. Novel medical therapies will be of use in a limited subgroup of patients.
Differential targeting of components of the dystrophin complex to the postsynaptic membrane

Accumulating evidence points to the participation of dystroglycan in the clustering of nicotinic acetylcholine receptors at the neuromuscular junction [Côtéet al. (1999) Nature Genet. , 3, 338–342]. Dystroglycan is part of a multimolecular complex, either associated with dystrophin (the dystrophin‐associated protein complex) at the sarcolemma or with utrophin (the utrophin‐associated protein complex) at the neuromuscular junction. Understanding the assembly of this complex at the developing synapse led us to investigate, in Torpedo electrocyte, the intracellular routing and the targeting of several of its components, including dystroglycan, syntrophin, dystrophin and dystrobrevin. We previously demonstrated that acetylcholine receptors and rapsyn, the 43‐kDa receptor‐associated protein at the synapse, are cotargeted to the postsynaptic membrane via the exocytic pathway [Marchand et al. (2000) J. Neurosci. , 20, 521–528]. Using cell fractionation, immunopurification and immuno‐electron microscope techniques, we show that β‐dystroglycan, an integral glycoprotein that constitutes the core of the dystrophin‐associated protein complex localized at the innervated membrane, is transported together with acetylcholine receptor and rapsyn in post‐Golgi vesicles en route to the postsynaptic membrane. Syntrophin, a peripheral cytoplasmic protein of the complex, associates initially with these exocytic vesicles. Conversely, dystrophin and dystrobrevin were absent from these post‐Golgi vesicles and associate directly with the postsynaptic membrane. This study provides the first evidence for a separate targeting of the various components of the dystrophin‐associated protein complex and a step‐by‐step assembly at the postsynaptic membrane.
Cigarette smoking is a risk factor for Alzheimer's Disease: an analysis controlling for tobacco industry affiliation.

To examine the relationship between smoking and Alzheimer's disease (AD) after controlling for study design, quality, secular trend, and tobacco industry affiliation of the authors, electronic databases were searched; 43 individual studies met the inclusion criteria. For evidence of tobacco industry affiliation, http://legacy.library. ucsf.edu was searched. One fourth (11/43) of individual studies had tobacco-affiliated authors. Using random effects meta-analysis, 18 case control studies without tobacco industry affiliation yielded a non-significant pooled odds ratio of 0.91 (95% CI, 0.75-1.10), while 8 case control studies with tobacco industry affiliation yielded a significant pooled odds ratio of 0.86 (95% CI, 0.75-0.98) suggesting that smoking protects against AD. In contrast, 14 cohort studies without tobacco-industry affiliation yielded a significantly increased relative risk of AD of 1.45 (95% CI, 1.16-1.80) associated with smoking and the three cohort studies with tobacco industry affiliation yielded a non-significant pooled relative risk of 0.60 (95% CI 0.27-1.32). A multiple regression analysis showed that case-control studies tended to yield lower average risk estimates than cohort studies (by -0.27 +/- 0.15, P=0.075), lower risk estimates for studies done by authors affiliated with the tobacco industry (by -0.37 +/- 0.13, P=0.008), no effect of the quality of the journal in which the study was published (measured by impact factor, P=0.828), and increasing secular trend in risk estimates (0.031/year +/- 0.013, P=0.02). The average risk of AD for cohort studies without tobacco industry affiliation of average quality published in 2007 was estimated to be 1.72 +/- 0.19 (P< 0.0005). The available data indicate that smoking is a significant risk factor for AD.
Current Internet use and preferences of IVF and ICSI patients.

BACKGROUND Nowadays, the Internet has a tremendous impact on modern society, including healthcare practice. The study aim was to characterize current Internet use by IVF and ICSI patients and to identify their preferences regarding Internet applications in fertility care. METHODS A total of 163 couples with fertility problems awaiting an IVF or ICSI procedure in the University Medical Centre Nijmegen, The Netherlands, was asked to complete a written questionnaire on Internet use in general, and also for fertility-related problems, preferences regarding Internet applications in fertility care and demographic characteristics. RESULTS The response rate was 82%. In total, 81% of infertile couples used the Internet. Multivariate logistic regression analysis showed ethnic background and annual family income to be significant predictors of Internet use. Some 66% of Internet users and 54% of the total study population used the Internet for fertility-related problems. The female partners were the main Internet users with regard to fertility-related issues. In terms of preferences of the study participants, the majority favoured personal medical information online. CONCLUSIONS Most infertile couples used the Internet with respect to fertility-related problems and were interested in implementation of Internet applications in fertility care. Healthcare providers should actively participate in the development and implementation of Internet applications in fertility care.
Relations between Word Perception and Production - New Theory and Data on the Verbal Transformation Effect

Abstract This paper outlines a detailed theory of relations between word perception and production, and reports five experiments testing prediction, of the theory for the verbal transformation effect (VTE), the perceptual changes that occur when an acoustically presented word is repeated via computer loop for prolonged periods. Within this interactive activation theory, VTEs occur to the extent that lexical nodes determining the perception of speech are satiated due to repeated activation. However, perception shares lexical nodes with production in the theory, so that when subjects concurrently produce (shadow) a recurring word in VTE experiments, lexical nodes for production provide the basis for concurrent perception, and not the acoustic input. However, satiation of lexical nodes is offset by aspects of the production process, so that few VTEs accompany concurrent production, even silent production (mouthing and inner speech). Findings reported here supported this Node Structure theory account of VTEs, but challenged both Parallel Distributed Processing theories (that postulate inhibition between lexical nodes), and corollary discharge theories (that postulate inhibition at the phonetic level between production and perception nodes).
The Role of Node Heterogeneity in the Coupled Spreading of Epidemics and Awareness

Exploring the interplay between information spreading and epidemic spreading is a topic that has been receiving increasing attention. As an efficient means of depicting the spreading of information, which manifests as a cascade phenomenon, awareness cascading is utilized to investigate this coupled transmission. Because in reality, different individuals facing the same epidemic will exhibit distinct behaviors according to their own experiences and attributes, it is important for us to consider the heterogeneity of individuals. Consequently, we propose a heterogeneous spreading model. To describe the heterogeneity, two of the most important but radically different methods for this purpose, the degree and k-core measures, are studied in this paper through three models based on different assumptions. Adopting a Markov chain approach, we succeed in predicting the epidemic threshold trend. Furthermore, we find that when the k-core measure is used to classify individuals, the spreading process is robust to these models, meaning that regardless of the model used, the spreading process is nearly identical at the macroscopic level. In addition, the k-core measure leads to a much larger final epidemic size than the degree measure. These results are cross-checked through numerous simulations, not only of a synthetic network but also of a real multiplex network. The presented findings provide a better understanding of k-core individuals and reveal the importance of considering network structure when investigating various dynamic processes.
Malignant melanoma of the vagina: A case report and review of the literature

Primary malignant melanoma of the vagina is an extremely rare variant of melanoma that accounts for <3% of all vaginal malignancies. Primary malignant melanoma of the vagina has a worse prognosis as compared with non-genital melanomas or other vaginal malignant neoplasms. A-35-year-old female had a diagnosis of primary malignant melanoma of the vagina. A local excision of the tumor was first performed, followed by a radical excision as a further therapeutic measure. The patient returned after three weeks, presenting with a vesico-vaginal fistula. A conservative operation was subsequently performed in order to improve the quality of life of the patient. Pelvic metastases were identified 6 months after the completion of the last surgical therapy and subsequent follow-up examinations were performed in another hospital. The present case study describes the clinical features and surgical procedures of this patient with primary malignant melanoma of the vagina. In conclusion, melanoma of the vagina is an extremely aggressive cancer and the overall prognosis is poor despite the various treatment options.
An Analysis of the Vowel Formants of the Young versus Old Speakers in the Buckeye Corpus

The purpose of this study was to measure the first two vowel formants of the forty male and female speakers (twenty young vs. old male speakers and twenty young vs. old female speakers) from the Buckeye Corpus of Conversational Speech and to examine the vowel formant changes across two generations (younger vs. older). The results indicated that the vowel space of the younger generation (in their thirties or less) shifted to the lower left position compared to those of the older generation (in their forties or more) in both male and female speakers. When the results were compared to those of Peterson & Barney (1952), it appears that differences can be found in the size of the vowel spaces through time.
Misconceptions of Gender: Sex, Masculinity, and the Measurement of Crime

Gender is a widely used variable within criminological literature. Unfortunately, most researchers attempt to measure gender with a single item on a survey. Most often this item simply asks respondents to indicate his/her biologically determined “sex” (i.e., male or female), which cannot fully address the complex nature of a concept such as gender. This issue has limited criminologists' ability to fully understand the relationship between gender and criminality, with most of the emphasis placed on the fact that males commit more crimes than females. However, this argument does little to explain why some males commit crimes while others do not. Reliance on these externally derived measures may have also led to oversimplified conceptualizations of other important criminological variables such as race and socioeconomic status. A newer, deeper conceptualization of these variables may lead to a better understanding of how they relate to both crime and delinquency. The current paper assesses the current predominant conceptualization of gender within criminological literature and offers a new conceptualization based on Ken Wilber's Integral, All Quadrant, All Level Model, or AQAL.
Rational growth of branched nanowire heterostructures with synthetically encoded properties and function

Branched nanostructures represent unique, 3D building blocks for the “bottom-up” paradigm of nanoscale science and technology. Here, we report a rational, multistep approach toward the general synthesis of 3D branched nanowire (NW) heterostructures. Single-crystalline semiconductor, including groups IV, III–V, and II–VI, and metal branches have been selectively grown on core or core/shell NW backbones, with the composition, morphology, and doping of core (core/shell) NWs and branch NWs well controlled during synthesis. Measurements made on the different composition branched NW structures demonstrate encoding of functional p-type/n-type diodes and light-emitting diodes (LEDs) as well as field effect transistors with device function localized at the branch/backbone NW junctions. In addition, multibranch/backbone NW structures were synthesized and used to demonstrate capability to create addressable nanoscale LED arrays, logic circuits, and biological sensors. Our work demonstrates a previously undescribed level of structural and functional complexity in NW materials, and more generally, highlights the potential of bottom-up synthesis to yield increasingly complex functional systems in the future.
Growth differentiation factor 15 is a promising diagnostic and prognostic biomarker in colorectal cancer

Although various studies have demonstrated that growth differentiation factor 15 (GDF15) might be a potential diagnostic and prognostic marker in colorectal cancer (CRC) patients, the results are inconsistent and the statistical power of individual studies is also insufficient. An original study was conducted to explore the diagnostic and prognostic value of serum GDF15 in CRC patients. We also conducted a meta‐analysis study which aimed to summarize the diagnostic and prognostic performance of serum GDF15 in CRC. We searched PubMed and ISI Web of Knowledge up to 1 November 2014 for eligible studies. In order to explore the diagnostic performance of GDF15, standardized mean difference (SMD) and their 95% confidence intervals (CI) were estimated and receiver‐operating characteristic (ROC) curves were constructed. For prognostic meta‐analysis, study‐specific hazard ratios (HRs) of serum GDF15 for survival were summarized. A total of eight studies were included in the meta‐analyses. Our results revealed that serum GDF15 levels in CRC patients were higher than those in healthy controls (SMD = 1.08, 95% CI: 0.56–1.59, P < 0.001). For discriminating CRC from healthy controls, the AUC of GDF15 was 0.816 (95% CI: 0.792–0.838). The sensitivity and specificity were 58.9% (95% CI: 55.0–62.8) and 92.08% (95% CI: 89.2–94.4), respectively, when a cut‐off value of 1099 pg/ml was established. Besides, higher GDF15 expression level was associated with worse overall survival for CRC patients (pooled HR = 2.09, 95% CI: 1.47–2.96). In conclusion, the present meta‐analysis suggests that serum GDF15 may be a useful diagnostic and prognostic biomarker for CRC.
The Effects of Appraised Severity and Efficacy in Promoting Water Conservation: An Informational Analysis

To test Rogers' protection motivation theory and Fishbein's behavioral intention model, subjects observed one of four water conservation films which differed according to message severity (high/low) and efficacy of conserving (high/low). A questionnaire assessed the impact of the films on (1) the arguments (informational items) presented; (2) beliefs external to the films; (3) fear arousal; (4) Fishbein's mediating variables SN and Aact; (5) appraised severity and efficacy; and (6) behavioral intention to conserve water. High efficacy and low severity messages increased positive evaluative attitudes (Aact) toward conserving water. Although there was no effect for these manipulations on behavioral intention, the film groups, when compared with a control group which did not observe a fdm, showed significantly greater intentions to conserve water. These results are accounted for through an informational analysis of the beliefs affected by the films. This analysis provided evidence that feelings of citizen's duty to conserve water and concern about the water situation are closely related to behavioral intentions. This analysis did not support Fishbein's assertion of a dominant mediational role for SN and/or Aact in predicting behavioral intentions. The possible inclusion of a moral norm measure as a third component of Fishbein's model is discussed.
Customer Directed Advertising and Product Quality

This paper studies the relationship between three key elements of the marketing mix, namely, price, product, and promotion, in a model where a seller employs informative advertising to launch a new product. We propose a fairly general advertising technology for the study of three promotional strategies—mass, imperfectly targeted, and customer directed advertising (CDA). We find that both the private and the social incentives to use distinct advertising strategies are aligned, and that sales are likely to be promoted through CDA. Compared to mass advertising, with CDA the social planner reduces quantity and downgrades quality whereas the seller sometimes upgrades it. Our model of targeting with endogenous product quality provides some new insights into the way the transition from mass to specialized advertising can affect market outcomes. Quality distortions imply that (i) even if CDA increases the market price, the degree of market power need not increase and (ii) CDA may yield a welfare loss even if it leads to a lower market price. This discussion paper has resulted in a publication in the Journal of Economics and Management Strategy , 2006, 15(4), 943-68.
Adjuvant Treatment Modalities, Prognostic Predictors and Outcomes of Uterine Carcinosarcomas

Purpose The purpose of this study is to evaluate the clinicopathological characteristics, treatment, and prognosis of uterine carcinosarcoma (UC). Materials and Methods A retrospective review of three cancer registry databases in Turkey was conducted for identification of patients diagnosed with UC between January 1, 1996, and December 31, 2012. We collected clinicopathological data in order to evaluate factors important in disease- free survival (DFS) and overall survival (OS). Results A total of 66 patients with UC with a median age of 65.0 years were included in the analysis. The median survival time of all patients was 37.5 months and the 5-year OS rate was 59.1%. In early stage patients (I-II) who received adjuvant chemotherapy (CT) with radiation therapy (RT), the median DFS and OS was 44 months and 55 months, respectively, compared to 34.5 months and 36 months, respectively, in patients who received adjuvant RT or CT alone (hazard ratio [HR], 1.4; 95% confidence interval [CI], 0.7 to 3.1 for DFS; p=0.23 and HR, 2.2; 95% CI, 0.9 to 5.3 for OS; p=0.03). In advanced stage patients (III-IV), the median DFS and OS of patients receiving adjuvant RT with CT was 25 months and 38 months, respectively, compared to 23.5 months and 24.5 months, respectively, in patients receiving adjuvant RT or CT alone (HR, 3.1; 95% CI, 0.6 to 16.0 for DFS; p=0.03); (HR, 3.3; 95% CI, 0.7 to 15.0 for OS; p=0.01). In multivariate analysis, advanced International Federation of Gynecology and Obstetrics (FIGO) stage and suboptimal surgery showed significant association with poor OS. Conclusion In patients with early or advanced stage UC, adjuvant CT with RT is associated with improved DFS and OS, as compared to CT or RT alone.