Miracle-dz/UniFAR-FTUs huggingface dataset:
Rayleigh scattering in the transmission spectrum of HAT-P-18b

We have performed ground-based transmission spectroscopy of the hot Jupiter HAT-P-18b using the ACAM instrument on the William Herschel Telescope (WHT). Differential spectroscopy over an entire night was carried out at a resolution of R ≈ 400 using a nearby comparison star. We detect a blueward slope extending across our optical transmission spectrum that runs from 4750 to 9250 A. The slope is consistent with Rayleigh scattering at the equilibrium temperature of the planet (852 K). We do not detect enhanced sodium absorption, which indicates that a high-altitude haze is masking the feature and giving rise to the Rayleigh slope. This is only the second discovery of a Rayleigh-scattering slope in a hot Jupiter atmosphere from the ground, and our study illustrates how ground-based observations can provide transmission spectra with precision comparable to the Hubble Space Telescope.
Point‐Nonpoint Trading – Can It Work? 1

Ribaudo, Marc O. and Jessica Gottlieb, 2011. Point‐Nonpoint Trading – Can It Work? Journal of the American Water Resources Association (JAWRA) 47(1):5‐14. DOI: 10.1111/j.1752‐1688.2010. 00454.x
Quantum reverse hypercontractivity

We develop reverse versions of hypercontractive inequalities for quantum channels. By generalizing classical techniques, we prove a reverse hypercontractive inequality for tensor products of qubit depolarizing channels. We apply this to obtain a rapid mixing result for depolarizing noise applied to large subspaces and to prove bounds on a quantum generalization of non-interactive correlation distillation.
Integration of Subthreshold and Suprathreshold Excitatory Barrages along the Somatodendritic Axis of Pyramidal Neurons

Neurons integrate inputs arriving in different cellular compartments to produce action potentials that are transmitted to other neurons. Because of the voltage- and time-dependent conductances in the dendrites and soma, summation of synaptic inputs is complex. To examine summation of membrane potentials and firing rates, we performed whole-cell recordings from layer 5 cortical pyramidal neurons in acute slices of the rat's somatosensory cortex. We delivered subthreshold and suprathreshold stimuli at the soma and several sites on the apical dendrite, and injected inputs that mimic synaptic barrages at individual or distributed sites. We found that summation of subthreshold potentials differed from that of firing rates. Subthreshold summation was linear when barrages were small but became supralinear as barrages increased. When neurons were discharging repetitively the rules were more diverse. At the soma and proximal apical dendrite summation of the evoked firing rates was predominantly sublinear whereas in the distal dendrite summation ranged from supralinear to sublinear. In addition, the integration of inputs delivered at a single location differed from that of distributed inputs only for suprathreshold responses. These results indicate that convergent inputs onto the apical dendrite and soma do not simply summate linearly, as suggested previously, and that distinct presynaptic afferents that target specific sites on the dendritic tree may perform unique sets of computations.
Normalizing shadows in multi-temporal aerial frame imagery using relative radiometric adjustments to support near-real-time change detection

This study addresses the problem of shadows in multi-temporal imagery, which is a key issue with change detection approaches based on image comparison. We apply image-to-image radiometric normalizations including histogram matching (HM), mean-variance (MV) equalization, linear regression based on pseudo-invariant features (PIF-LR), and radiometric control sets (RCS) representing high- and low-reflectance extrema, for the novel purpose of normalizing brightness of transient shadows in high spatial resolution, bi-temporal, aerial frame image sets. Efficient shadow normalization is integral to remote sensing procedures that support disaster response efforts in a near-real-time fashion, including repeat station image (RSI) capture, wireless data transfer, shadow detection (as precursor to shadow normalization), and change detection based on image differencing and visual interpretation. We apply the normalization techniques to imagery of suburban scenes containing shadowed materials of varied spectral reflectance characteristics, whereby intensity (average of red, green, and blue spectral band values) under fully illuminated conditions is known from counterpart reference images (time-1 versus time-2). We evaluate the normalization results using stratified random pixel samples within transient shadows, considering central tendency and variance of differences in intensity relative to the unnormalized images. Overall, MV equalization yielded superior results in our tests, reducing the radiometric effects of shadowing by more than 85 percent. The HM and PIF-LR approaches showed slightly lower performance than MV, while the RCS approach proved unreliable among scenes and among stratified intensity levels. We qualitatively evaluate a shadow normalization based on MV equalization, describing its utility and limitations when applied in change detection. Application of image-to-image radiometric normalization for brightening shadowed areas in multi-temporal imagery in this study proved efficient and effective to support change detection.
Modulation of the induction of nitric oxide synthase by eicosanoids in the murine macrophage cell line J774

The effect of eicosanoids on the induction of nitric oxide synthase in the murine macrophage cell line J774 has been studied. We found that prostaglandin E2 (PGE2) and iloprost (a stable analogue of prostacyclin) both at nanomolar concentrations inhibited the lipopolysaccharide stimulated induction of NO synthase. In contrast PGF2α, U46619, a stable analogue of thromboxane A2, leukotrienes B4 and C4 had no effect. These data demonstrate that the l‐arginine: NO pathway in macrophages may be modulated by prostanoids.
Effects of Brain‐Derived Neurotrophic Factor (BDNF) on Compression‐Induced Spinal Cord Injury: BDNF Attenuates Down‐Regulation of Superoxide Dismutase Expression and Promotes Up‐Regulation of Myelin Basic Protein Expression

Neurotrophins enhance the survival of cells in the nervous system under both physiological and pathological conditions, such as those caused by disease or trauma. We recently demonstrated that expression of brain-derived neurotrophic factor (BDNF) was up-regulated in neurons and glia after compression-induced spinal cord injury (SCI). We show here the effects of BDNF on the oligodendrocyte survival and functional recovery after SCI. The effects of intrathecally administered BDNF on both Cu/Zn superoxide dismutase (CuZnSOD) and myelin basic protein (MBP) expression were examined using rats that had received compression-induced spinal cord injury. CuZnSOD expression in the spinal cord was down-regulated within 24 h of compression-induced injury and then recovered. Continuous infusion of BDNF inhibited the acute down-regulation of CuZnSOD expression. In situ hybridization showed that CuZnSOD was expressed in both neurons and glia. Although MBP expression was greatly reduced after injury, BDNF administration promoted the recovery of MBP expression nearly to a control level after 2 wk. Furthermore, BDNF administration also prompted behavioral recovery. These results suggest BDNF's usefulness in human clinical applications. The attenuation of CuZnSOD down-regulation may be related to a protective effect of BDNF and the promotion of MBP up-regulation may be related to a long-lasting restorative effect.
Cassini Imaging Science: Initial Results on Saturn's Rings and Small Satellites

Images acquired of Saturn's rings and small moons by the Cassini Imaging Science Subsystem (ISS) during the first 9 months of Cassini operations at Saturn have produced many new findings. These include new saturnian moons; refined orbits of new and previously known moons; narrow diffuse rings in the F-ring region and embedded in gaps within the main rings; exceptionally fine-scale ring structure in moderate– to high–optical depth regions; new estimates for the masses of ring-region moons, as well as ring particle properties in the Cassini division, derived from the analysis of linear density waves; ring particle albedos in select ring regions; and never-before-seen phenomena within the rings.
Lithological controls on hillslope sediment supply: insights from landslide activity and grain size distributions

The volumes, rates and grain size distributions of sediment supplied from hillslopes represent the initial input of sediment delivered from upland areas and propagated through sediment routing systems. Moreover, hillslope sediment supply has a significant impact on landscape response time to tectonic and climatic perturbations. However, there are very few detailed field studies characterizing hillslope sediment supply as a function of lithology and delivery process. Here, we present new empirical data from tectonically‐active areas in southern Italy that quantifies how lithology and rock strength control the landslide fluxes and grain size distributions supplied from hillslopes. Landslides are the major source of hillslope sediment supply in this area, and our inventory of ~2800 landslides reveals that landslide sediment flux is dominated by small, shallow landslides. We find that lithology and rock strength modulate the abundance of steep slopes and landslides, and the distribution of landslide sizes. Outcrop‐scale rock strength also controls the grain sizes supplied by bedrock weathering, and influences the degree of coarsening of landslide supply with respect to weathering supply. Finally, we show that hillslope sediment supply largely determines the grain sizes of fluvial export, from catchments and that catchments with greater long‐term landslide rates deliver coarser material. Therefore, our results demonstrate a dual control of lithology on hillslope sediment supply, by modulating both the sediment fluxes from landslides and the grain sizes supplied by hillslopes to the fluvial system. Copyright © 2017 John Wiley & Sons, Ltd.
Formal Decomposition Method and Parametric Normal Forms

We introduce a formal decomposition method for efficiently computing the parametric normal form of nonlinear dynamical systems with multiple parameters. Recently introduced notions of formal basis style and costyle are applied through formal decomposition method to obtain the simplest parametric normal form for degenerate nonlinear parametric center. The necessary formulas are derived and implemented using Maple to compute the simplest parametric normal form of degenerate and nondegenerate nonlinear centers. Our program computes the order of any planar parametric systems associated with this singularity.
A ratio-independent and gain-insensitive algorithmic analog-to-digital converter

The design of a new configuration of capacitor-ratio-independent and gain-insensitive algorithmic analog-to-digital converter (ADC) is described. Through the use of switched-capacitor techniques, the proposed new ADC is insensitive to the capacitor-ratio accuracy as well as to the finite gain and offset voltage of the operational amplifiers. The switching error becomes the only major error source. Both SWITCAP and HSPICE (simulation program with IC emphasis) simulations are performed to verify the performance of the new ADC. It is shown that a 14-b resolution at the sampling frequency of 10 kHz can be achieved when the capacitor ratios have a variation of 10% and the finite gain of the operational amplifiers is only 66 dB. The ADC can be realized by simple analog elements in a small chip area. <<ETX>>
Genetics of Behçet's Disease

Behçet's disease (BD) is a systemic inflammatory disorder characterized mainly by recurrent oral and genital ulcers and eye involvement. Although the pathogenesis remains poorly understood, a variety of studies have demonstrated that genetic predisposition is a major factor in disease susceptibility. Peculiar geographical distribution of BD along the ancient Silk Road has been regarded as evidence supporting genetic influence. The observed aggregation of BD in families of patients with BD is also supportive for a genetic component in its etiology. HLA-B51 (B510101 subtype) is the most strongly associated genetic marker for BD in countries on the Silk Road. In recent years, several genome-wide association studies and genetic polymorphism studies have also found new genetic associations with BD, which may have a supplementary role in disease susceptibility and/or severity. The author reviewed the HLA and non-HLA genetic association studies.
Effector Genomics Accelerates Discovery and Functional Profiling of Potato Disease Resistance and Phytophthora Infestans Avirulence Genes

Potato is the world's fourth largest food crop yet it continues to endure late blight, a devastating disease caused by the Irish famine pathogen Phytophthora infestans. Breeding broad-spectrum disease resistance (R) genes into potato (Solanum tuberosum) is the best strategy for genetically managing late blight but current approaches are slow and inefficient. We used a repertoire of effector genes predicted computationally from the P. infestans genome to accelerate the identification, functional characterization, and cloning of potentially broad-spectrum R genes. An initial set of 54 effectors containing a signal peptide and a RXLR motif was profiled for activation of innate immunity (avirulence or Avr activity) on wild Solanum species and tentative Avr candidates were identified. The RXLR effector family IpiO induced hypersensitive responses (HR) in S. stoloniferum, S. papita and the more distantly related S. bulbocastanum, the source of the R gene Rpi-blb1. Genetic studies with S. stoloniferum showed cosegregation of resistance to P. infestans and response to IpiO. Transient co-expression of IpiO with Rpi-blb1 in a heterologous Nicotiana benthamiana system identified IpiO as Avr-blb1. A candidate gene approach led to the rapid cloning of S. stoloniferum Rpi-sto1 and S. papita Rpi-pta1, which are functionally equivalent to Rpi-blb1. Our findings indicate that effector genomics enables discovery and functional profiling of late blight R genes and Avr genes at an unprecedented rate and promises to accelerate the engineering of late blight resistant potato varieties.
Dexamethasone can stimulate G1-S phase transition in human airway fibroblasts in asthma

Corticosteroids are the first line of therapy for asthma. Whether they alter the progression of airway remodelling in asthma is, as yet, unknown. To determine whether corticosteroids could alter the fibroblast cell cycle the current authors studied the effect of dexamethasone on cultured airway fibroblasts obtained from nine mild-to-moderate, steroid-naïve asthmatics (forced expiratory volume in one second 78±4% predicted), and seven normal controls. Fibroblasts were cultured from endobronchial biopsies obtained via bronchoscopy. Cells were exposed to dexamethasone (10-9–10-7 M) and studied at 72 h to determine differences in progression through the cell cycle. In asthmatic fibroblasts, dexamethasone, at concentrations of 10-8M and 10-7M, nearly doubled the number of cells in the S phase (17.8±3.0% and 18.4±3.1%, respectively) compared with untreated fibroblasts (10.3±1.4%). There was no significant effect in normal control fibroblasts. Dexamethasone induced hyperphosphorylation of the tumour suppressor, retinoblastoma (RB) in asthmatic fibroblasts; fibroblasts from normal controls had significantly less hyperphosphorylation of RB. No difference in protein expression of the CCAAT/enhancer binding protein α between the two groups was detected. This study suggests that dexamethasone can stimulate G1-S phase cell cycle transition in human airway fibroblasts obtained from asthmatics. Whether this leads to enhanced airway remodelling in some individuals remains to be determined.
Dying for work: The magnitude of US mortality from selected causes of death associated with occupation.

BACKGROUND Deaths due to occupational disease and injury place a heavy burden on society in terms of economic costs and human suffering. METHODS We estimate the annual deaths due to selected diseases for which an occupational association is reasonably well established and quantifiable, by calculation of attributable fractions (AFs), with full documentation; the deaths due to occupational injury are then added to derive an estimated number of annual deaths due to occupation. RESULTS Using 1997 US mortality data, the estimated annual burden of occupational disease mortality resulting from selected respiratory diseases, cancers, cardiovascular disease, chronic renal failure, and hepatitis is 49,000, with a range from 26,000 to 72,000. The Bureau of Labor Statistics estimates there are about 6,200 work-related injury deaths annually. Adding disease and injury data, we estimate that there are a total of 55,200 US deaths annually resulting from occupational disease or injury (range 32,200-78,200). CONCLUSIONS Our estimate is in the range reported by previous investigators, although we have restricted ourselves more than others to only those diseases with well-established occupational etiology, biasing our estimates conservatively. The underlying assumptions and data used to generate the estimates are well documented, so our estimates may be updated as new data emerges on occupational risks and exposed populations, providing an advantage over previous studies. We estimate that occupational deaths are the 8th leading cause of death in the US, after diabetes (64,751) but ahead of suicide (30,575), and greater than the annual number of motor vehicle deaths per year (43,501).
The One-Dimensional Dynamic Dispatch Waves Problem

We study same-day delivery systems by formulating the dynamic dispatch waves problem (DDWP), which models a depot where delivery requests arrive dynamically throughout a service day. At any dispatch epoch (wave), the information available to the decision maker is (1) a set of known, open requests that remain unfulfilled, and (2) a set of potential requests that may arrive later in the service day. At each wave, the decision maker decides whether or not to dispatch a vehicle, and if so, which subset of open requests to serve, with the objective of minimizing expected vehicle operating costs and penalties for unserved requests. We consider the DDWP with a single delivery vehicle and request destinations on a line, where vehicle operating times and costs depend only on the distance between points. We propose an efficient dynamic programming approach for the deterministic variant, and leverage it to design an optimal a priori policy with predetermined routes for the stochastic case. We then show that fully dy.
Race-based job discrimination, disparities in job control, and their joint effects on health.

OBJECTIVES To examine disparities between job control scores in Black and White subjects and attempt to discern whether self-rated low job control in Blacks may arise from structural segregation into different jobs, or represents individual responses to race-based discrimination in hiring or promotion. METHODS Data from the National Survey of Midlife in the United States (MIDUS) were analyzed by mixed-effects linear regression and variance regression to determine the effects of grouping by occupation, and racial discrimination in hiring or promotion, on control scores from the Job Content Questionnaire in Black and White subjects. Path analyses were constructed to determine the mediating effect of discrimination on pathways from education and job control to self-rated health. RESULTS Black subjects exhibited lower mean job control scores compared to Whites (mean score difference 2.26, P < 0.001) adjusted for age, sex, education, and income. This difference narrowed to 1.86 when adjusted for clustering by occupation, and was greatly reduced by conditioning on race-based discrimination (score difference 1.03, P = 0.12). Path analyses showed greater reported discrimination in Blacks with increasing education, and a stronger effect of job control on health in Black subjects. CONCLUSIONS Individual racially-based discrimination appears a stronger determinant than structural segregation in reduced job control in Black workers, and may contribute to health disparities consequent on work.
Stochastic optimal control for a general class of dynamic resource allocation problems

We consider a general class of dynamic resource allocation problems within a stochastic optimal control framework. This class of problems arises in a wide variety of applications, each of which intrinsically involves resources of different types and demand with uncertainty and/or variability. The goal is to dynamically allocate capacity for every resource type in order to serve the uncertain/ variable demand and maximize the expected net-benefit over a time horizon of interest based on the rewards and costs associated with the different resources. We derive the optimal control policy within a singular control setting, which includes easily implementable algorithms for governing the dynamic adjustments to resource allocation capacities over time. Numerical experiments investigate various issues of both theoretical and practical interest, quantifying the significant benefits of our approach over alternative optimization approaches.
Normal modes and discovery of high‐order cross‐frequencies in the DBV white dwarf GD 358

We present a detailed mode identification performed on the 1994 Whole Earth Telescope (WET) run on GD 358. The results are compared with that obtained for the same star from the 1990 WET data. The two temporal spectra show very few qualitative differences, although amplitude changes are seen in most modes, including the disappearance of the mode identified as k=14 in the 1990 data. The excellent coverage and signal-to-noise ratio obtained during the 1994 run lead to the secure identification of combination frequencies up to fourth order, i.e. peaks that are sums or differences of up to four parent frequencies, including a virtually complete set of second-order frequencies, as expected from harmonic distortion. We show how the third-order frequencies are expected to affect the triplet structure of the normal modes by back-interacting with them. Finally, a search for l=2 modes was unsuccessful, not verifying the suspicion that such modes had been uncovered in the 1990 data set.
Study of the atmospheric refraction in a single-mode instrument – application to AMBER/VLTI

This paper presents a study of the atmospheric refraction and its effect on the light coupling efficiency in an instrument using single-mode optical fibers. We show the analytical approach which allowed us to assess the need to correct the refraction in J- and H-bands while observing with an 8-m Unit Telescope. We then developed numerical simulations to go further in calculations. The hypotheses on the instrumental characteristics are those of AMBER (Astronomical Multi BEam combineR), the near infrared focal beam combiner of the Very Large Telescope Interferometric mode (VLTI), but most of the conclusions can be generalized to other single-mode instruments. We used the software package caos (Code for Adaptive Optics Systems) to take into account the atmospheric turbulence effect after correction by the ESO system MACAO (Multi-Application Curvature Adaptive Optics). The opto-mechanical study and design of the system correcting the atmospheric refraction on AMBER is then detailed. We showed that the atmospheric refraction becomes predominant over the atmospheric turbulence for some zenith angles z and spectral conditions: for z larger than 30° in J-band for example. The study of the optical system showed that it allows to achieve the required instrumental performance in terms of throughput in J- and H-bands. First observations in J-band of a bright star, alpha Cir star, at more than 30° from zenith clearly showed the gain to control the atmospheric refraction in a single mode instrument, and validated the operating law.