Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of TPA on ion fluxes and DNA synthesis in vascular smooth muscle cells

Previous reports have suggested that phorbol esters can decrease the affinity of epidermal growth factor (EGF) for its cellular receptors. Investigations of the consequences of the interaction between phorbol esters and EGF, however, have been limited to EGF-stimulated Na/H exchange in A431 cells (Whitely, B., D. Cassel, Y.-X. Zuang, and L. Glaser, 1984, J. Cell Biol., 99:1162-1166). In the present study, the effect of the phorbol ester 12-O-tetradecanoyl phorbol-13-acetate (TPA) on EGF-stimulated ion transport and DNA synthesis was determined in cultured vascular smooth muscle cells (A7r5). It was found that TPA stimulated Na/H exchange when added alone (half-maximal stimulatory concentration, 25 nM). However, when cells were pretreated with TPA and then challenged with EGF, TPA significantly inhibited EGF-stimulated Na/H exchange (78%; half-maximal inhibition [Ki] at 2.5 nM). Subsequently the effects of TPA on Na/K/Cl co-transport were measured. TPA was observed to inhibit Na/K/Cl co-transport (half-maximal inhibitory concentration, 50 nM) and also to inhibit EGF-stimulated Na/K/Cl co-transport (100%; Ki at 5 nM). Finally, the effects of TPA on DNA synthesis were assessed. TPA had a modest stimulatory effect on DNA synthesis (half-maximal stimulatory concentration, 6 nM), but had a significant inhibitory effect on EGF-stimulated DNA synthesis (56%; Ki at 5 nM). These findings suggest that the inhibitory effect of TPA on EGF-receptor functions goes beyond previously reported effects on Na/H exchange in A431 cells and extends to EGF-stimulation of Na/K/Cl co- transport and DNA synthesis in vascular smooth muscle cells.
The Period-Luminosity Relation for the Large Magellanic Cloud Cepheids Derived from Spitzer Archival Data

Using Spitzer archival data from the SAGE (Surveying the Agents of a Galaxy’s Evolution) program, we derive the Cepheid period-luminosity (P-L) relation at 3.6, 4.5, 5.8, and 8.0 μm for Large Magellanic Cloud (LMC) Cepheids. These P-L relations can be used, for example, in future extragalactic distance scale studies carried out with the James Webb Space Telescope. We also derive Cepheid period-color (P-C) relations in these bands and find that the slopes of the P-C relations are relatively flat. We test the nonlinearity of these P-L relations with the F-statistical test and find that the 3.6, 4.5, and 5.8 μm P-L relations are consistent with linearity. However, the 8.0 μm P-L relation presents possible but inconclusive evidence of nonlinearity.
Mechanism of Interaction of Acanthamoeba Actophorin (ADF/Cofilin) with Actin Filaments*

We characterized the interaction ofAcanthamoeba actophorin, a member of ADF/cofilin family, with filaments of amoeba and rabbit skeletal muscle actin. The affinity is about 10 times higher for muscle actin filaments (K d = 0.5 μm) than amoeba actin filaments (K d = 5 μm) even though the affinity for muscle and amoeba Mg-ADP-actin monomers (K d = 0.1 μm) is the same (Blanchoin, L., and Pollard, T. D. (1998) J. Biol. Chem. 273, 25106–25111). Actophorin binds slowly (k + = 0.03 μm −1 s−1) to and dissociates from amoeba actin filaments in a simple bimolecular reaction, but binding to muscle actin filaments is cooperative. Actophorin severs filaments in a concentration-dependent fashion. Phosphate or BeF3 bound to ADP-actin filaments inhibit actophorin binding. Actophorin increases the rate of phosphate release from actin filaments more than 10-fold. The time course of the interaction of actophorin with filaments measured by quenching of the fluorescence of pyrenyl-actin or fluorescence anisotropy of rhodamine-actophorin is complicated, because severing, depolymerization, and repolymerization follows binding. The 50-fold higher affinity of actophorin for Mg-ADP-actin monomers (K d = 0.1 μm) than ADP-actin filaments provides the thermodynamic basis for driving disassembly of filaments that have hydrolyzed ATP and dissociated γ-phosphate.
The Difference, System and ‘Double‐D’ GMM Panel Estimators in the Presence of Structural Breaks

The effects of structural breaks in dynamic panels are more complicated than in time series models as the bias can be either negative or positive. This paper focuses on the effects of mean shifts in otherwise stationary processes within an instrumental variable panel estimation framework. We show the sources of the bias and a Monte Carlo analysis calibrated on United States bank lending data demonstrates the size of the bias for a range of auto-regressive parameters. We also propose additional moment conditions that can be used to reduce the biases caused by shifts in the mean of the data.
Inflation, Tax Rules, and Investment: Some Econometric Evidence

This paper presents econometric evidence on the effect of tax incentives on business Investment in the United States in the period from 1953 through1978. The analysis emphasizes that the Interaction of inflation and existing tax rules has contributed substantially to the decline of business investment since the late 1960's.Because the investment process is far too complex for any simple econometric model to be convincing, I have estimated three quite different models of investment behavior. The strength of the empirical evidence rests on the fact that all three specifications support the same conclusion. More generally, the analysis and evidence show that theoretical models of macroeconomic equilibrium should specify explicitly the role of distortionary taxes, especially taxes on capital income. The failure to include such tax rules can have dramatic and misleading effects on the qualitative as well as the quantitative properties of macroeconomic theories. This paper was presented as the Fisher-Shultz Lecture at the Fourth World Congress of the Econometric Society, 29 August 1980, in Aix-en-Province.
Testing the Finance-Growth Link: is There a Difference Between Developed and Developing Countries?

We revisit the evidence of the existence of a long-run link between financial intermediation and economic growth, by testing of cointegration between the growth rate of real GDP, control variables and three series reflecting financial intermediation. We consider a model with a factor structure that allows us to determine whether the finance-growth link is due to cross countries dependence and/or whether it characterises countries with strong heterogeneities. We employ techniques recently proposed in the panel data literature, such as PANIC analysis and cointegration in common factor models. Our results show differences between the developed and developing countries. We run a comparative regression analysis on the 1980-2006 period and find that financial intermediation is a positive determinant of growth in developed countries, while it acts negatively on the economic growth of developing countries.
Do Casinos Really Cause Crime

This paper discusses the recent study by Grinols and Mustard (2006), which examines the relationship between casinos and county-level crime in the U.S. The authors conclude that casinos cause a significant amount of crime. However, there are a number of problems with their analysis. The most serious problem is that their paper uses a crime rate that excludes the visiting population at risk, thereby overstating the crime rate in casino counties. Second, the crime data used are potentially inaccurate. Third, the results may suffer from a bias caused by counties self-selecting into the â€œcasino countyâ€ category. Fourth, the dummy variables used to account for casinos do not allow the authors to isolate the crime effect caused by casinos. Finally, the authors make conclusions that are not supported by their data, analysis, and results.
Identification of the Plasma Metabolomics as Early Diagnostic Markers between Biliary Atresia and Neonatal Hepatitis Syndrome

Early detection is the most effective way to improve the clinical outcome of biliary atresia (BA). Emerging metabolomics provides a powerful platform for discovering novel biomarkers and biochemical pathways to improve early diagnosis. The aim of this study is to find the potential biomarkers to distinguish BA from neonatal hepatitis syndrome (NHS) by using a metabolomics method. We comprehensively analyzed the serum metabolites in a total of 124 blood samples from patients with BA or neonatal hepatitis syndrome (NHS) and from normal individuals using advanced metabolomic approaches, and found that the levels of glutarylcarnitine (C5DC) significantly increased in the BA group while the levels of threonine (Thr) significantly rose in the NHS group comparing with the other groups. The levels of glutamic acid (Glu) in the BA group were significantly elevated compared to those in the NHS group, but still lower than the hyperbilirubinemia and normal controls. The levels of propionyl carnitine (C3), isovaleryl carnitine (C5) and glutamine (Gln) were reduced in the BA group compared to those in the NHS group, but still higher than the hyperbilirubinemia and normal controls. This study demonstrates the possibility of metabolomics as non-invasive biomarkers for the early detection of BA and also provides new insight into pathophysiologic mechanisms for BA.
Do Business Groups Change with Market Development?

Khanna and Yafeh hypothesize that business groups should be more common in economies with less developed markets and institutions. We test the time-series version of this hypothesis by looking at changes in Chilean groups over 20 years (1990–2009). In this period, Chile experienced a deep economic transformation as measured by common proxies of market development (e.g., per capita income doubled). Despite this dramatic transformation, groups remained mostly unchanged in terms of relative size, industrial diversification, vertical integration, control structures, internal capital markets, and reliance on external funds (minority equity plus debt). Only leverage increased. Also, groups' initial conditions were uncorrelated with market development at the time of formation. This evidence casts doubts on the institutional-voids hypothesis, although more subtle institutional voids, not captured by the type of macro proxies we use, might explain the existence and resilience of business groups.
Executive summary of the Stages of Reproductive Aging Workshop + 10: addressing the unfinished agenda of staging reproductive aging.

OBJECTIVE The aim of this article is to summarize the recommended updates to the 2001 Stages of Reproductive Aging Workshop (STRAW) criteria. The 2011 STRAW + 10 reviewed advances in understanding of the critical changes in hypothalamic-pituitary-ovarian function that occur before and after the final menstrual period. METHODS Scientists from five countries and multiple disciplines evaluated data from cohort studies of midlife women and in the context of chronic illness and endocrine disorders on change in menstrual, endocrine, and ovarian markers of reproductive aging including antimüllerian hormone, inhibin-B, follicle-stimulating hormone, and antral follicle count. Modifications were adopted by consensus. RESULTS STRAW + 10 simplified bleeding criteria for the early and late menopausal transition, recommended modifications to criteria for the late reproductive stage (Stage -3) and the early postmenopause stage (Stage +1), provided information on the duration of the late transition (Stage -1) and early postmenopause (Stage +1), and recommended application regardless of women's age, ethnicity, body size, or lifestyle characteristics. CONCLUSIONS STRAW + 10 provides a more comprehensive basis for assessing reproductive aging in research and clinical contexts. Application of the STRAW + 10 staging system should improve comparability of studies of midlife women and facilitate clinical decision making. Nonetheless, important knowledge gaps persist, and seven research priorities are identified.
The Medicare experience with end-stage renal disease: Trends in incidence, prevalence, and survival

This article presents a detailed account of the incidence, prevalence, and survival experience of people with end-stage renal disease (ESRD) covered by Medicare. The number of new entrants into the ESRD program has risen since its inception. This increase is greatest for people whose cause of renal failure is primary hypertensive disease or diabetic nephropathy. The program incidence rates for black people is 2.8 times that of white people. Incidence is highest for persons 65 to 69 years of age. Total patient survival is 44 percent 5 years after renal failure onset. Total Medicare enrollment for ESRD quadrupled between the years 1974 and 1981.
Software verification games: Designing Xylem, The Code of Plants

Formal software verification is a software engineering technique for modeling a software system’s source code, and then proving properties about it, such as freedom from security vulnerabilities. Though proofs are largely automated, formal source code modeling is time consuming and requires substantial human attention. Xylem: The Code of Plants is an iPad game where players make observations about unusual plants, and thereby model the behavior of software loops. With large numbers of players, the goal of Xylem is to have players model the behavior of large software systems faster, and at lower cost, than is currently achievable with formal verification experts. We present an overview of major design challenges and approaches encountered in the design of a game for crowd-sourced formal software verification. A core challenge is the need to accurately reflect the structure of real-world software source code in a game setting, without showing the source code text to players. This goal created a tension with the need to design a game that is a fun, engaging experience, which often requires simplification of the core activities of the player. Another challenge is not knowing what is the solution to a particular problem, and the resulting difficulty in providing scoring feedback to the player. These design considerations are of interest for crowd-sourcing games in general, and software engineering games in particular.
Intracoronary microparticles and microvascular obstruction in patients with ST elevation myocardial infarction undergoing primary percutaneous intervention.

AIMS Microparticles (MP) are cell-derived fragments known to be increased in the blood of patients with acute coronary syndromes. We aimed to assess, in ST elevation myocardial infarction (STEMI), the systemic and local (in the culprit coronary artery) levels of platelet-derived MP (PMP, CD42+CD31+) and endothelial-derived MP (EMP, CD42-CD31+) and their relation to indexes of microvascular obstruction (MVO). METHODS AND RESULTS In 78 STEMI patients undergoing successful primary percutaneous coronary intervention, blood samples were sequentially drawn from the aorta and the culprit coronary artery for cytofluorimetric MP detection. Thrombolysis in myocardial infarction (TIMI) flow, thrombus score (TS), corrected TIMI frame count (cTFC), myocardial blush grade (MBG), quantitative blush evaluator (QuBE) score, and 90 min ST resolution (ΣSTR) were calculated. Both PMP and EMP levels were significantly higher in the intracoronary than in the aortic blood samples. Intracoronary PMP and EMP levels were positively related to TS and cTFC and inversely related to MBG and QuBE. Aortic PMP (but not EMP) levels were related to TS and cTFC and, inversely, to QuBE. Intracoronary PMP were independently related to angiographic and electrocardiographic MVO in a multivariate model. CONCLUSION The correlations of intracoronary EMP and of both systemic and intracoronary PMP levels with TS support the role of MP as markers of ongoing thrombosis. Moreover, the correlation of intracoronary MP with indexes of microvascular dysfunction suggests, for the first time, a possible direct role of MP in the pathogenesis of MVO.
Conducting a Statewide Health Examination Survey: The Arkansas Cardiovascular Health Examination Survey (ARCHES)

Introduction The Arkansas Cardiovascular Health Examination Survey is a health and nutrition examination survey designed to serve as a demonstration project for collection of data on the prevalence of chronic diseases and their risk factors at the state level. The survey was conducted from mid-2006 through early 2008. Methods We chose a cross-sectional representative sample of adult residents in Arkansas by using a 3-stage, cluster sample design. Trained interviewers conducted interviews and examinations in respondents' homes, collecting data on risk factors and diseases, blood pressure and anthropometric measurements, and blood and urine samples for analysis and storage. Food frequency questionnaires provided dietary and nutrient intake data. We accomplished the project using a collaborative model among several programs and partners within the state. Results A total of 4,894 eligible households were contacted by telephone. Of these, refusals accounted for 2,748, and 2,146 gave initial consent to participate, for an initial response rate of 44%. The final number of completed household visits was 1,385, resulting in a final response rate of 28.3%. Conclusion The Arkansas Cardiovascular Health Examination Survey is among the first state-level health and nutrition examination surveys to be conducted in the United States. By using a collaborative model and leveraging federal funds, we engaged several partners who provided additional resources to complete the project. The survey provides the state with valuable state-level data and information for program design and delivery.
Epidemiology of Invasive Haemophilus influenzae Disease, Europe, 2007–2014

We describe the epidemiology of invasive Haemophilus influenzae disease during 2007–2014 in 12 European countries and assess overall H. influenzae disease trends by serotype and patient age. Mean annual notification rate was 0.6 cases/100,000 population, with an increasing annual trend of 3.3% (95% CI 2.3% to 4.3%). The notification rate was highest for patients <1 month of age (23.4 cases/100,000 population). Nontypeable H. influenzae (NTHi) caused 78% of all cases and showed increasing trends among persons <1 month and >20 years of age. Serotype f cases showed an increasing trend among persons >60 years of age. Serotype b cases showed decreasing trends among persons 1–5 months, 1–4 years, and >40 years of age. Sustained success of routine H. influenzae serotype b vaccination is evident. Surveillance systems must adopt a broad focus for invasive H. influenzae disease. Increasing reports of NTHi, particularly among neonates, highlight the potential benefit of a vaccine against NTHi.
Entrepreneurship and Dynamic Capitalism: The Economics of Business Firm Formation and Growth

The Dynamics of Economic Growth Dynamic Capitalism's Conflict with General Equilibrium Economics Schumpeter's Theory of Creative Destruction The Dynamic Capitalism Typology Data Systems to Support Dynamic Capitalism Data Foundations for Measuring Firm Dynamics Evidence of Dynamic Capitalism in the U.S. Economy Entrepreneurial Success: New Firm Survival Measuring New Firm Formation and Economic Growth The Future of Dynamic Capitalism References Index
Intact implicit probabilistic sequence learning in obstructive sleep apnea

Obstructive sleep apnea (OSA) belongs to the sleep‐related breathing disorders and is associated with cognitive impairments in learning and memory functions. The impairments in attention‐demanding cognitive functions such as working memory and executive functions are well established in OSA; however, it remains unknown if less attention‐demanding implicit sequence learning is affected. In the present study, we examined implicit sequence learning in OSA to probe the functional integrity of this fundamental learning mechanism. We used listening span to measure complex working memory capacity and the alternating serial reaction time (ASRT) task, which enables us to measure general skill learning and sequence‐specific learning separately. Twenty OSA patients and 20 healthy controls participated in this study. Our data show dissociation between working memory and implicit sequence learning in OSA. Surprisingly, OSA patients showed preserved general skill and sequence‐specific learning in spite of the possible hypoxia and sleep restriction. In contrast, working memory performance measured by listening span task was impaired in the OSA group. This finding suggests selective susceptibility of more attention‐demanding cognitive functions in this patient population, while implicit learning remains intact. Our findings draw attention the fact that disordered sleep may have less impact on the integrity of structures connected to implicit sequence learning.
Diversity Gain for DVB-H by Using Transmitter/Receiver Cyclic Delay Diversity

The objective of this paper is to investigate different diversity techniques for broadcast networks that will minimize the complexity and improve received SNR of broadcast systems. Resultant digital broadcast networks would require fewer transmitter sites and thus be more cost-effective and have less environmental impact. The techniques can be applied to DVB-T, DVB-H and DAB systems that use Orthogonal Frequency Division Multiplexing (OFDM). These are key radio broadcast network technologies, which are expected to complement emerging technologies such as WiMAX and future 4G networks for delivery of broadband content. Transmitter and receiver diversity technologies can increase the frequency and time selectivity of the resulting channel transfer function at the receiver. Diversity exploits the statistical nature of fading due to multipath and reduces the likelihood of deep fading by providing a diversity of transmission signals. Multiple signals are transmitted in such a way as to ensure that several signals reach the receiver each with uncorrelated fading. Transmit diversity is more practical than receive diversity due to the difficulty of locating two receive antennas far enough apart in a small mobile device. The schemes examined here comply with existing DVB standards and can be incorporated into existing systems without change. The diversity techniques introduced in this paper are applied to the DVB-H system. Bit error performance investigations were conducted by simulation for different DVB-H and diversity parameters
Respiratory sensory gating measured by respiratory-related evoked potentials in generalized anxiety disorder

The perception of respiratory sensations plays an important role both in respiratory diseases and in anxiety disorders. However, little is known about the neural processes underlying respiratory sensory perception, especially in patient groups. Therefore, the present study examined whether patients with generalized anxiety disorder (GAD) would demonstrate altered respiratory sensory gating compared to a healthy control group. Respiratory-related evoked potentials (RREP) were measured in a paired inspiratory occlusion paradigm presenting two brief occlusion stimuli (S1 and S2) within one inspiration. The results showed a significantly greater S2/S1 ratio for the N1 component of the RREP in the GAD group compared to the control group. Our findings suggest altered respiratory sensory processing in patients with GAD, which might contribute to altered perception of respiratory sensations in these patients.
Takagi Factorization on GPU using CUDA

Takagi factorization or symmetric singular value decomposition is a special form of SVD applicable to symmetric complex matrices. The computation takes advantage of symmetry to reduce computation and storage requirements. The Jacobi method with chess tournament ordering was used to perform the computation in parallel on a GPU using the CUDA programming model. We were able to achieve speedups of over 11x and 7x over CPU serial and Pthreads implementations, respectively, for matrix sizes greater than 512 × 512.