Miracle-dz/UniFAR-FTUs huggingface dataset:
The Effects of Organic Solvents on the Physicochemical Properties of Human Serum Albumin Nanoparticles.

BACKGROUND Recently, applications of albumin nanoparticles as drug delivery carriers have increased. Most toxicology studies have shown that surface chemistry and size of nanoparticles play an important role in biocompatibility and toxicity. OBJECTIVE The effect of desolvating agents with different chemical properties on the size of synthesized HSA NPs was investigated. MATERIALS AND METHODS Acetone, ethanol, methanol, and acetonitrile were used to synthesize HSA NPs with controllable size by desolvation method. Scanning electron microscopy (SEM), dynamic light scattering (DLS), and circular dichroism (CD) were employed to characterize produced particles. Finally, the toxicity of HSA NPs synthesized under different conditions was evaluated on PC-12 cells. RESULTS The sizes of synthesized particles differed according to the different solvents used. The sizes were 275.3 nm, 155.3 nm, 100.11 nm, and 66.2 nm for acetonitrile, ethanol, acetone, and methanol, respectively. CD showed that larger NPs had more changes in the secondary structures. Finally, the toxicity monitored on the cultured PC-12 cells showed no significant toxic effect through treating with these NPs at different concentrations (0-500 μg.mL-1). CONCLUSIONS The size of HSA NPs has a strong dependency on the desolvating agent. The mechanism in which the desolvating agent affects the size of HSA NPs is complex. Various factors such as dielectric constant, polarity, functional groups, and hydrogen bonding of the solvents have the potential to affect the size and structure of HSA NPs. CD analysis suggested that the solvent denaturing capability had a critical effect on the HSA particle size. The stronger denaturing capability of the solvent resulted in the larger HSA particle size.
Wake Up and Non-Wake up stroke: A comparative Hospital Based Study.

Background: Almost 25% of all acute ischemic strokes occur during sleep with the patients or relatives become aware of the neurological deficits as they wake up. The present study was conducted with an aim to find out the prevalence of wakeup stroke along with clinical profile and outcome of wake up stroke as compared to non-wake up stroke. Methods: All patients of age group 18 years or more presenting with stroke during the 12-month study period were included. Data was compared with non-wakeup stroke by applying Chi square test, Fischer exact test and Yates corrections was used to evaluate the association between the variables defining the clinical profile and outcome. Results: Patients of non wake-up stroke were higher (63%) as compared to wake-up stroke (37%). Out of 37 wake-up stroke patients, ischemic stroke was found in 23(62.16%) and hemorrhagic stroke in 14(37.83%) patients. Out of 14(37.83%) wakeup strokes; in 8(57.14%) patients lesion was parenchymal and in 5(35.71%) multiple lesions were present. Higher incidence of diabetes mellitus in wake up strokes was found. Atherothrombotic and cardioembolic strokes contribute to majority of the cases of ischemic stroke. Conclusions: The incidence of stroke increases dramatically with advancing age irrespective of gender. Diabetes mellitus emerged as the main risk factor in wake-up stroke. In wake up hemorrhagic stroke, the higher percentage of thalamic bleed was found. Improvement was appreciated more in non wake-up stroke as compared to wake-up stroke.
Birth and Neonatal Outcomes Following Opioid Use in Pregnancy: A Danish Population-Based Study

Background Few population-based data exist on birth outcomes in women who received opioid maintenance treatment during pregnancy. We therefore examined adverse birth outcomes in women exposed to methadone or buprenorphine during pregnancy and the risk of neonatal abstinence syndrome (NAS) among neonates exposed to buprenorphine, methadone, and/or heroin in utero. Patients and Methods This study included all female Danish residents with a live birth or a stillbirth from 1997 to 211. We identified the study population, use of opioids and opioid substitution treatment, birth outcomes, and NAS through medical registers. Birth outcomes included preterm birth (born before 38th gestational week), low-birth weight (LBW) (<2,500 g, restricted to term births), small for gestational age (SGA) (weight <2 standard deviations from the sex- and gestational-week-specific mean), congenital malformations, and stillbirths. We used log-binomial regression to estimate the prevalence ratio (PR) for birth outcomes. Results Among 95,172 pregnancies in a total of 571,823 women, we identified 557 pregnancies exposed to buprenorphine, methadone, and/or heroin (167 to buprenorphine, 197 to methadone, 28 to self-reported heroin, and 165 to combinations). Compared with nonexposed pregnancies, prenatal opioid use was associated with greater prevalence of preterm birth (PR of 2.8 (95% confidence interval (CI), 2.3–3.4)), LBW among infants born at term (PR of 4.3 (95% CI, 3.0–6.1)), and being SGA (PR of 2.7 (95% CI, 1.9–4.3)). Restricting the analyses to women who smoked slightly lowered these estimates. The prevalence of congenital malformations was 8.3% in opioid-exposed women compared with 4.2% in nonexposed women (PR of 2.0 (95% CI, 1.5–2.6)). The risk of NAS ranged from 7% in neonates exposed to buprenorphine only to 55% in neonates exposed to methadone only or to opioid combinations. Conclusion The maternal use of buprenorphine and methadone during pregnancy was associated with increased prevalence of adverse birth outcomes, and this increase could only be explained to a smaller extent by increased prevalence of smoking. The risk of NAS was eight-fold higher in methadone-exposed neonates than that in buprenorphine-exposed neonates, but this difference may at least partly be explained by differences in underlying indications (analgesic versus opioid maintenance treatment) between the two groups.
Diet composition and activity level of at risk and metabolically healthy obese American adults

Obesity often clusters with other major cardiovascular disease risk factors, yet a subset of the obese appears to be protected from these risks. Two obesity phenotypes are described, (i) “metabolically healthy” obese, broadly defined as body mass index (BMI) ≥ 30 kg/m2 and favorable levels of blood pressure, lipids, and glucose; and (ii) “at risk” obese, BMI ≥ 30 with unfavorable levels of these risk factors. More than 30% of obese American adults are metabolically healthy. Diet and activity determinants of obesity phenotypes are unclear. We hypothesized that metabolically healthy obese have more favorable behavioral factors, including less adverse diet composition and higher activity levels than at risk obese in the multi‐ethnic group of 775 obese American adults ages 40‐59 years from the International Population Study on Macro/Micronutrients and Blood Pressure (INTERMAP) cohort.
Who trusts?: The origins of social trust in seven societies

This article identifies six main theories of the determinants of social trust, and tests them against survey data from seven societies, 1999-2001. Three of the six theories of trust fare rather poorly and three do better. First and foremost, social trust tends to be high among citizens who believe that there are few severe social conflicts and where the sense of public safety is high. Second, informal social networks are associated with trust. And third, those who are successful in life trust more, or are more inclined by their personal experience to do so. Individual theories seem to work best in societies with higher levels of trust, and societal ones in societies with lower levels of trust. This may have something to do with the fact that our two low trust societies, Hungary and Slovenia, happen to have experienced revolutionary change in the very recent past, so that societal events have overwhelmed individual circumstances.
Beyond usability -- affect in web browsing

Beyond Usability — Affect in Web Browsing. (August 2006) Liqiong Deng, B.A., Fudan University, China; M.A., Fudan University, China Chair of Advisory Committee: Dr. Marshall Scott Poole This research concentrates on the visual aesthetics of a website, investigating the web user’s affective/emotional reactions to different designs of web homepage aesthetics and their influence on subsequent behaviors of web users. Drawing on the existing theories and empirical findings in environmental psychology, human-computer interaction, aesthetics, and marketing research literature, a research model is developed to explore the relationships between the visual aesthetic qualities of a website homepage – webpage visual complexity and order, induced emotional states in users, and users’ approach behaviors toward the website. The model predicts that the visual aesthetics of a web homepage elicit specific emotional responses by provoking intrinsic feelings of pleasantness / unpleasantness, arousal, as well as motivational pleasantness / unpleasantness in web users. These elicited emotional responses, which mediate the effect of homepage aesthetic features, in turn affect web users’ subsequent behaviors toward the website, such as further approaching/exploring or avoiding the website. A set of pilot studies and a main laboratory experiment were conducted to test the model and its associated hypotheses. Based on the results of pilot studies, 12 versions of a Gift website’s homepage, which varied at four levels of complexity and
OUTCOME OF COMBINED PENETRATING KERATOPLASTY WITH VITREORETINAL SURGERY FOR MANAGEMENT OF SEVERE OCULAR INJURIES

Purpose To assess the effectiveness of a combined procedure (pars plana vitrectomy with temporary keratoprosthesis, vitreoretinal surgery, and penetrating keratoplasty) and to determine which factors influence corneal transplant success rates. Methods Records for 34 severely injured eyes of 31 consecutive patients who underwent penetrating keratoplasty in combination with vitreoretinal surgery between 1991 and 1998, with a follow-up of at least 12 months, were evaluated retrospectively. Analysis was focused on ocular history, functional and anatomic anterior and posterior segment outcome, and complications. Results Penetrating keratoplasty was performed in 10 eyes (29%) within 8 weeks of trauma and in 24 eyes (71%) as a secondary procedure. Initial improvement in visual acuity (VA) was achieved in 47% of eyes; at the end of the follow-up, 74% of the eyes had attained equal or better VA than the initial postsurgical VA. Reasons for poor final VA were hypotony or phthisis (35%) and recurrent retinal detachment (11%). Corneal grafts remained clear for 1 year in 65% of eyes. Transplant failure was less in eyes that did not need a permanent silicone oil tamponade, when the retina was attached before surgery, and in eyes that were grafted later after trauma and received no further surgery. These were some conditions that were associated with a longer mean graft survival time, but without statistical significance. There was no difference in eyes according to the trauma mechanism, preoperative intraocular pressure, or graft size. Conclusions Penetrating keratoplasty in severely injured eyes is often complicated by ciliary body malfunction and secondary transplant failure. Although the functional outcome of a combined procedure is limited by primary and secondary tissue destruction, preserving ambulatory vision is possible and thus improves the quality of life, at least in patients with single remaining eyes.
Pre-Service Portfolios: A Base for Professional Growth

We studied first-year teachers who had developed professional portfolios in their pre- service program. Data came from two interviews with 11 graduates. Participants valued the portfolio process, most continuing to maintain their professional portfolios and to use aspects of the process with their students. Two frameworks, “The Portfolio Organizer” and “retell, relate, reflect,” supported portfolio use. Factors affecting continued portfolio implementation included first-year teaching pressures, the influence of other teachers, and external expectations. The first-year teachers experienced a positive change in attitude and acquired confidence as they refined their use of portfolios. L’etude porte sur l’utilisation des portfolios professionnels par des enseignants en formation des maitres. Les donnees proviennent de deux entrevues menees aupres de 11 etudiants diplomes. Les participants apprecient la methode du portfolio ; la plupart les tiennent a jour et en utilisent certains elements avec leurs eleves. Deux systemes, « The Portfolio Organizer » et « retell, relate, reflect », favorisent l’utilisation des porfolios. Parmi les facteurs ayant une incidence sur le recours aux portfolios, les auteures mentionnent les pressions inherentes a l’enseignement lors de la premiere annee, l’influence des autres enseignants et les attentes externes. Au cours de leur premiere annee, les enseignants deviennent plus surs d’eux-memes a mesure qu’ils raffinent leur utilisation des portfolios.
Nephrotic syndrome due to glomerulopathy in an Irish dairy cow

NEPHROTIC syndrome, a clinical entity characterised by proteinuria, hypoalbuminaemia, oedema and hypercholesterolaemia ([Maxie and Newman 2007][1]), results from increased glomerular permeability due to glomerular injury ([White and others 1986][2]). In cattle, nephrotic syndrome is usually caused
Dominance, Egalitarianism and Friendship at a Dog Daycare Facility.

This dissertation examines dominance, play, affiliation and social preferences in a group of 24 domestic dogs that socialize regularly at a dog daycare facility. In Chapter 1, we analyzed the frequencies and directions of aggression, submission, and dominance displays. Submission was the best indicator of dominance relationships and resulted in a significantly linear hierarchy in the group. Age was significantly correlated with dominance rank with older dogs out‐ranking younger dogs. Muzzle‐licking met most of the criteria for a formal display of submission in dogs, but was not displayed in most relationships. Only 29% of all possible pairs had discernable dominance relationships. In Chapter 2, we examined the relationship between dominance and friendly behavior (play and affiliation) and identified four relationship styles among the dogs. Twenty‐two percent of all possible pairs had known dominance relationships and also exchanged friendly behaviors (formal relationships), 21% of all pairs exchanged friendly behavior but had no discernable dominance relationship (egalitarian relationships), 50% of all pairs were never observed exchanging friendly or agonistic behaviors (non‐interactive relationships), and 7% of pairs had known dominance relationships but did not exchange friendly behavior (agonistic
The Lived Experience of a Critical Illness—A Social Worker's Reflection

Critical illness, admission to an intensive care unit, and prolonged hospitalization all impact on the psychosocial functioning of an individual. This article highlights my own experience of a critical illness in an autoethnographic study thereby attempting to add knowledge to the scarcity of research from the patient's point of view. By writing this article, I was able to construct, deconstruct, and reconstruct my emotions, behavior, and the sequence of events in order to understand the impact of my critical illness. With this article I hope to invite healthcare professionals into my world of critical illness for better understanding of the patient's experience.
Resilience Training in a Population of Deployed Personnel

The U.S. military has developed prophylactic interventions to mitigate effects from stress. The project reported is a first of its kind descriptive assessment of the delivery of resilience training in a deployed environment. The Connor-Davidson Resilience Scale and an inventory of stress, morale, performance, and use of specific behaviors were administered before and after resilience training was implemented for all personnel assigned to a military facility in Afghanistan. There was a small positive relation between resilient thinking and self-reported morale, but, despite the training, both resilient thinking and morale were observed to decline across the deployment period. This descriptive effort can provide some baseline for commanders’ expectations in implementation of resilience training.
Hindsight Bias

Hindsight bias occurs when people feel that they “knew it all along,” that is, when they believe that an event is more predictable after it becomes known than it was before it became known. Hindsight bias embodies any combination of three aspects: memory distortion, beliefs about events’ objective likelihoods, or subjective beliefs about one’s own prediction abilities. Hindsight bias stems from (a) cognitive inputs (people selectively recall information consistent with what they now know to be true and engage in sensemaking to impose meaning on their own knowledge), (b) metacognitive inputs (the ease with which a past outcome is understood may be misattributed to its assumed prior likelihood), and (c) motivational inputs (people have a need to see the world as orderly and predictable and to avoid being blamed for problems). Consequences of hindsight bias include myopic attention to a single causal understanding of the past (to the neglect of other reasonable explanations) as well as general overconfidence in the certainty of one’s judgments. New technologies for visualizing and understanding data sets may have the unintended consequence of heightening hindsight bias, but an intervention that encourages people to consider alternative causal explanations for a given outcome can reduce hindsight bias.
The Gcn2 Kinase as a Cell Cycle Regulator

Cell cycle progression through G1 phase is of particular importance because this is the phase where the decision to embark on another cell cycle is made. An aberrant G1/S transition often leads to cell cycle deregulation and cancer development. Therefore, there is a complex regulatory network to ensure timely entry into S phase, coordinating initiation of DNA replication with growth and stress signals. We have studied the response of fission yeast cells to ultraviolet (UV) irradiation in G1 phase and identified a Gcn2-dependent checkpoint that delays entry into S phase. UV irradiation activates Gcn2 which, in turn, phosphorylates the translation initiation factor eIF2α and depresses translation. Phosphorylation of eIF2α is a well-known response to various forms of stress, but whether or how this response is causing the specific cell cycle effects is not known. Here we discuss the relationships between Gcn2 activity, eIF2α phosphorylation, translation downregulation and cell cycle delay.
Development of readiness to change and self-efficacy in anorexia nervosa clients: personal perspectives

ABSTRACT Objective: Anorexia nervosa is a significant cause of physical and psychological morbidity. The Transtheoretical Model (TTM) is frequently used to conceptualise the process of intentional behaviour change. Instability and inconsistency of the TTM stages of change exist across anorexia symptom dimensions. The current study qualitatively explored readiness for change and self-efficacy in relation to six related but distinct anorexic symptom dimensions. Method: Fifteen individuals currently diagnosed with or recently recovered from anorexia participated in a semi-structured interview. Findings: Participants in the central stages of the TTM reported variability and instability in their readiness to change and self-efficacy across the six dimensions. Participants were most prepared to address cognitive/emotional issues and least prepared to alter their weight and avoidance of specific foods. Discussion: These findings extend previous quantitative research to suggest readiness for change and self-efficacy resemble motivational states rather than stages. The implications for clinicians are discussed.
Transient Recovery in a Rat Model of Familial Amyotrophic Lateral Sclerosis after Transplantation of Motor Neurons Derived from Mouse Embryonic Stem Cells

Embryonic stem (ES) cells can be induced to differentiate into motor neurons (MN). Animal models resembling MN degeneration and paralysis observed in familial amyotrophic lateral sclerosis (ALS) have been previously reported. In this work, we aimed to investigate whether transplanted MN could prevent motor deterioration in transgenic rats expressing a mutant form of human superoxide dismutase 1 (hSOD1G93A) associated with inherited ALS. Mouse ES cells were differentiated to neurons that express green fluorescent protein (GFP) under the promoter of the MN-specific gene hb9, as well as molecular markers indicative of MN identity. Cells were grafted into the lumbar spinal cord of adult wild-type (WT) or hSOD1G93A rats at 10 weeks of age, when transgenic animals are presymptomatic. Grafted cells with MN phenotype can survive for at least 1 week in hSOD1G93A animals. To quantitatively evaluate motor performance of WT and transgenic rats, we carried out weekly rotarod tests starting when the animals were 14 weeks old. Sham and grafted WT animals showed no decline in their ability to sustain themselves on the rotating rod. In contrast, sham hSOD1G93A rats decreased in motor performance from week 16 onwards, reaching paralysis by week 19 of age. In grafted transgenic animals, there was a significant improvement in rotarod competence at weeks 16 and 17 when compared to sham hSOD1G93A. However, in the following weeks, transplanted hSOD1G93A rats showed motor deterioration and eventually exhibited paralysis by week 19. At end-stage, we found only a few endogenous MN in sham and grafted hSOD1G93A rats by cresyl violet staining; no choline acetyl transferase-positive nor GFP-positive MN were present in grafted transgenic subjects. In contrast, WT rats analyzed at the same age possessed grafted GFP-positive MN in their spinal cords. These results strongly suggest that the transgenic hSOD1G93A environment is detrimental to grafted MN in the long term.
Configurable Multimode Embedded Floating-Point Units for FPGAs

Performance of field-programmable gate arrays (FPGAs) used for floating-point applications is poor due to the complexity of floating-point arithmetic. Implementing floating-point units (FPUs) on FPGAs consume a large amount of resources. This makes FPGAs less attractive for use in floating-point intensive applications. Therefore, there is a need for embedded FPUs in FPGAs. However, if unutilized, embedded FPUs waste space on the FPGA die. To overcome this issue, we propose a flexible multimode embedded FPU for FPGAs that can be configured to perform a wide range of operations. The floating-point adder and multiplier in our embedded FPU can each be configured to perform one double-precision operation or two single-precision operations in parallel. To increase flexibility further, access to the large integer multiplier, adder and shifters in the FPU is provided. Benchmark circuits were implemented on both a standard Xilinx Virtex-II FPGA and on our FPGA with embedded FPU blocks. The results using our embedded FPUs showed a mean area improvement of 5.5 times and a mean delay improvement of 5.8 times for the double-precision benchmarks, and a mean area improvement of 3.8 times and a mean delay improvement of 4.2 times for the single-precision benchmarks. The embedded FPUs were also shown to provide significant area and delay benefits for fixed-point and integer circuits.