Miracle-dz/UniFAR-FTUs huggingface dataset:
Perioperative pharmacokinetics of cefotaxime in serum and bile during continuous and intermittent infusion in liver transplant patients.

BACKGROUND Drug pharmacokinetics may be altered during liver transplantation. Cefotaxime (CTX), used as perioperative prophylaxis, demonstrates time-dependent killing and therefore continuous infusion might have pharmacodynamic advantages. OBJECTIVES To determine the pharmacokinetics of CTX and desacetylcefotaxime (DCTX) in serum, bile and urine during continuous and intermittent infusion when performing liver transplantation. METHODS Fifteen patients undergoing liver transplantation were studied after continuous infusion (CI) (4000 mg iv per 24 h following a loading dose of 1000 mg) and intermittent bolus infusion (BI) (1000 mg iv four times daily). Samples were collected during the first 48 h after liver transplantation. Concentrations of CTX and DCTX were determined by HPLC. RESULTS During surgery, the mean concentration in serum after CI was 18 mg/L. The lowest serum concentration was 5 mg/L in the CI group and levels were undetectable in the BI group. Target serum concentrations of > or =4 mg/L were reached for 100% of the dosing interval during CI and approximately 60% during BI. Post-operatively, the mean concentration in serum after CI was 26 mg/L. The lowest serum concentration was 8 mg/L in the CI group and levels were undetectable after BI. The peroperative pharmacokinetics of CTX in this patient group were deranged and variable, mainly caused by an increased volume of distribution and decreased hepatic clearance. Metabolism was hampered, but DCTX area under the curve (AUC)/CTX AUC ratios varying between 0.7-0.9 were reached peroperatively. Post-operatively, DCTX AUC/CTX AUC ratios were higher (1.1-1.4). Unchanged CTX in bile was approximately 0.1% of the administered dose, leading to concentrations >4 mg/L throughout the dosing interval for both regimens. CONCLUSION Although an intermittent bolus infusion of CTX 1000 mg produces t > target concentration for 60% of the dosing interval during liver transplantation, serum concentrations may be insufficient during the reperfusion phase. Continuous infusion overcomes this. Post-operatively, CTX clearance is impaired by decreased metabolic clearance and there is substantial accumulation of DCTX. In bile, sufficient concentrations of CTX and its active metabolite are reached with both regimens.
THE CREDIBILITY , COMPLETENESS AND ACCURACY OF INFORMATION ABOUT FIRST AID IN CASE OF CHOKING ON THE ROMANIAN WEBSITES

A large number of studies assessing the quality of medical websites in various languages have shown that the quality of health related information is problematic. Nevertheless, the Romanian medical cyberspace has not yet been systematically evaluated. The goal of our study was to assess the credibility and content quality of information about first aid in case of choking intended for the general population on the Romanian websites. We evaluated a sample of 20 websites selected from the Google's first search results pages. The compliance to the credibility criteria was very low, the coverage of the topic was medium and the accuracy was good but we found frequent omission of important information about the first aid procedure for choking. Websites with high completeness and accuracy scores were rare, therefore, users should check several websites in order to get thoroughly and correctly informed about the topic.
Basolateral plasma membrane localization of ouabain-sensitive sodium transport sites in the secretory epithelium of the avian salt gland

The distribution of Na+ pump sites (Na+-K+-ATPase) in the secretory epithelium of the avian salt gland was demonstrated by freeze-dry autoradiographic analysis of [(3)H] ouabain binding sites. Kinetic studies indicated that near saturation of tissue binding sites occurred when slices of salt glands from salt-stressed ducks were exposed to 2.2 μM ouabain (containing 5 μCi/ml [(3)H]ouabain) for 90 min. Washing with label-free Ringer's solution for 90 min extracted only 10% of the inhibitor, an amount which corresponded to ouabain present in the tissue spaces labeled by [(14)C]insulin. Increasing the KCl concentration of the incubation medium reduced the rate of ouabain binding but not the maximal amount bound. In contrast to the low level of ouabain binding to salt glands of ducks maintained on a freshwater regimen, exposure to a salt water diet led to a more than threefold increase in binding within 9-11 days. This increase paralleled the similar increment in Na+-K+-ATPase activity described previously. [(3)H]ouabain binding sites were localized autoradiographically to the folded basolateral plasma membrane of the principal secretory cells. The luminal surfaces of these cells were unlabeled. Mitotically active peripheral cells were also unlabeled. The cell-specific pattern of [(3)H]ouabain binding to principal secretory cells and the membrane-specific localization of binding sites to the nonluminal surfaces of these cells were identical to the distribution of Na+-K+-ATPase as reflected by the cytochemical localization of ouabain-sensitive and K+-dependent nitrophenyl phosphatase activity. The relationship between the nonluminal localization of Na+-K+-ATPase and the possible role of the enzyme n NaCl secretion is considered in the light of physiological data on electrolyte transport in salt glands and other secretory epithelia.
The PI3K/Akt/mTOR pathway in ovarian cancer: therapeutic opportunities and challenges

The phosphatidylinositol 3 kinase (PI3K) pathway is frequently altered in cancer, including ovarian cancer (OC). Unfortunately, despite a sound biological rationale and encouraging activity in preclinical models, trials of first-generation inhibitors of mammalian target of rapamycin (mTOR) in OC have demonstrated negative results. The lack of patient selection as well as resistance to selective mTOR complex-1 (mTORC1) inhibitors could explain the disappointing results thus far. Nonetheless, a number of novel agents are being investigated, including dual mTORC1/mTORC2, Akt, and PI3K inhibitors. Although it is likely that inhibition of the PI3K/Akt/mTOR pathway may have little effect in unselected OC patients, certain histological types, such as clear cell or endometrioid OC with frequent phosphatidylinositol-4,5-biphosphate 3-kinase, catalytic subunit alpha (PIK3CA) and/or phosphatase and tensin homolog (PTEN) alterations, may be particularly suited to this approach. Given the complexity and redundancy of the PI3K signaling network, PI3K pathway inhibition may be most useful in combination with either chemotherapy or other targeted therapies, such as MEK inhibitors, anti-angiogenic therapy, and hormonal therapy, in appropriately selected OC patients. Here, we discuss the relevance of the PI3K pathway in OC and provide an up-to-date review of clinical trials of novel PI3K inhibitors alone or in combination with cytotoxics and novel therapies in OC. In addition, the challenges of drug resistance and predictive biomarkers are addressed.
An ECG-based algorithm for the automatic identification of autonomic activations associated with cortical arousal.

OBJECTIVES EEG arousals are associated with autonomic activations. Visual EEG arousal scoring is time consuming and suffers from low interobserver agreement. We hypothesized that information on changes in heart rate alone suffice to predict the occurrence of cortical arousal. METHODS Two visual AASM EEG arousal scorings of 56 healthy subject nights (mean age 37.0 +/- 12.8 years, 26 male) were obtained. For each of 5 heartbeats following the onset of 3581 consensus EEG arousals and of an equal number of control conditions, differences to a moving median were calculated and used to estimate likelihood ratios (LRs) for 10 categories of heartbeat differences. Comparable to 5 consecutive diagnostic tests, these LRs were used to calculate the probability of heart rate responses being associated with cortical arousals. RESULTS EEG and ECG arousal indexes agreed well across a wide range of decision thresholds, resulting in a receiver operating characteristic (ROC) with an area under the curve of 0.91. For the decision threshold chosen for the final analyses, a sensitivity of 68.1% and a specificity of 95.2% were obtained. ECG and EEG arousal indexes were poorly correlated (r = 0.19, P <0.001, ICC = 0.186), which could in part be attributed to 3 outliers. The Bland-Altman plot showed an unbiased estimation of EEG arousal indexes by ECG arousal indexes with a standard deviation of +/- 7.9 arousals per hour sleep. In about two-thirds of all cases, ECG arousal scoring was matched by at least one (22.2%) or by both (42.5%) of the visual scorings. Sensitivity of the algorithm increased with increasing duration of EEG arousals. The ECG algorithm was also successfully validated with 30 different nights of 10 subjects (mean age 35.3 [ 13.6 years, 5 male). CONCLUSIONS In its current version, the ECG algorithm cannot replace visual EEG arousal scoring. Sensitivity for detecting <10-s EEG arousals needs to be improved. However, in a nonclinical population, it may be valuable to supplement visual EEG arousal scoring by this automatic, objective, reproducible, cheap, and time-saving method.
Asynchronous distributed state estimation for continuous-time stochastic processes

The problem of state estimation of a continuous-time stochastic process using an Asynchronous Distributed multi-sensor Estimation (ADE) system is considered. The state of a process of interest is estimated by a group of local estimators constituting the proposed ADE system. Each estimator is based, e.g., on a Kalman filter and performs single sensor filtration and fusion of its local results with the results from other/remote processors to compute possibly the best state estimates. In performing data fusion, however, two important issues need to be addressed namely, the problem of asynchronism of local processors and the issue of unknown correlation between asynchronous data in local processors. Both the problems, along with their solutions, are investigated in this paper. Possible applications and effectiveness of the proposed ADE approach are illustrated by simulated experiments, including a non-complete connection graph of such a distributed estimation system.
Regional T1 relaxation time constants in Ex vivo human brain: Longitudinal effects of formalin exposure

Relaxation time constants are useful as markers of tissue properties. Imaging ex vivo tissue is done for research purposes; however, T1 relaxation time constants are altered by tissue fixation in a time‐dependent manner. This study investigates regional changes in T1 relaxation time constants in ex vivo brain tissue over 6 months of fixation.
Association between Provider Volume and Healthcare Expenditures of Patients with Oral Cancer in Taiwan: A Population-Based Study

Background Oral cancer requires considerable utilization of healthcare services. Wide resection of the tumor and reconstruction with free flap are widely used. Due to high recurrence rate, close follow-up is mandatory. This study was conducted to explore the relationship between the healthcare expenditure of oncological surgery and one-year follow up and provider volume. Methods From the National Health Insurance Research Database published by the Taiwanese National Health Research Institute, the authors selected a total of 1300 oral cancer patients who underwent tumor resection and free flap reconstruction in 2008. Hierarchical linear regression analysis was subsequently performed to explore the relationship between provider volume and expenditures of oncological surgery and one-year follow-up period. Emergency department (ED) visits and 30-day readmission rates were also analyzed. Results The mean expenditure for oncological surgery was $11080±4645 (all costs are given in U.S. dollars) and $10129±9248 for one-year follow up. For oncological surgery expenditure, oral cancer patients treated by low-volume surgeons had an additional $845 than those in high-volume surgeons in mixed model. For one-year follow-up expenditure, patients in low-volume hospitals had an additional $3439 than those in high-volume hospitals; patient in low-volume surgeons and medium-volume surgeons incurred an additional expenditure of $2065 and $1811 than those in high-volume surgeons. Oral cancer patients treated in low-volume hospitals incurred higher risk of 30-day readmission rate (odds ratio, 6.6; 95% confidence interval, 1.6–27). Conclusions After adjusting for physician, hospital, and patient characteristics, low-volume provider performing wide excision with reconstructive surgery in oral cancer patients incurred significantly higher expenditure for oncological surgery and one-year healthcare per patient than did others with higher volumes. Treatment strategies adapted by high-volume providers should be further analyzed.
Best Practices in the Systematic Direct Observation of Student Behavior 63

Direct observation is one of the most widely used assessment procedures by school psychologists. In a survey of more than 1,000 school psychology practitioners, Wilson and Reschly (1996) found that of the 26 different types of assessment instruments listed across seven different assessment categories (e.g., ability/intelligence, social/emotional, visual/motor), structured observational methods were ranked highest in terms of frequency of use. Overall, practitioners report that they conduct more than 15 behavioral observations of student behavior during the course of a typical month. Systematic direct observation refers to observation of behavior other than behavior that has been explicitly elicited by a predetermined and standardized set of stimuli (i.e., test behavior (Salvia & Ysseldyke, 2001)). School psychology practitioners commonly use both naturalistic and systematic direct approaches to observing student behavior. Briefly, naturalistic observation approaches refer to those observational procedures where the observer enters specific situations (e.g., a classroom) and observes all that is going on with no predetermined behaviors in mind. Here, the most common way of recording observations is to keep an anecdotal record of the behaviors that seem important to the observer. In summarizing the information, the observer provides a complete description of the many behaviors and the context in which they occurred. In contrast, systematic direct approaches to behavioral observation are distinguished by five characteristics (Salvia & Ysseldyke, 2001). First, the goal of observation is to measure specific behaviors. Second, the behaviors being observed have been operationally defined a priori in a precise manner. Third, observations are conducted under standardized procedures and are highly objective in nature. Fourth, the times and places for observation are carefully selected and specified. Fifth, scoring and summarizing of data are standardized and do not vary from one observer to another. Both naturalistic and systematic direct approaches to observing behavior have proven useful in developing theory and practice related to the assessment and intervention of student behavior. This chapter provides an overview of (a) naturalistic observational procedures, (b) systematic direct observational procedures, and (c) observational instruments as they related to the observation of student behavior in the classroom.
Aminolevulinic Acid‐Photodynamic Therapy Combined with Topically Applied Vascular Disrupting Agent Vadimezan Leads to Enhanced Antitumor Responses

The tumor vascular‐disrupting agent (VDA) vadimezan (5,6‐dimethylxanthenone‐4‐acetic acid, DMXAA) has been shown to potentiate the antitumor activity of photodynamic therapy (PDT) using systemically administered photosensitizers. Here, we characterized the response of subcutaneous syngeneic Colon26 murine colon adenocarcinoma tumors to PDT using the locally applied photosensitizer precursor aminolevulinic acid (ALA) in combination with a topical formulation of vadimezan. Diffuse correlation spectroscopy (DCS), a noninvasive method for monitoring blood flow, was utilized to determine tumor vascular response to treatment. In addition, correlative CD31‐immunohistochemistry to visualize endothelial damage, ELISA to measure induction of tumor necrosis factor‐alpha (TNF‐α) and tumor weight measurements were also examined in separate animals. In our previous work, DCS revealed a selective decrease in tumor blood flow over time following topical vadimezan. ALA‐PDT treatment also induced a decrease in tumor blood flow. The onset of blood flow reduction was rapid in tumors treated with both ALA‐PDT and vadimezan. CD31‐immunostaining of tumor sections confirmed vascular damage following topical application of vadimezan. Tumor weight measurements revealed enhanced tumor growth inhibition with combination treatment compared with ALA‐PDT or vadimezan treatment alone. In conclusion, vadimezan as a topical agent enhances treatment efficacy when combined with ALA‐PDT. This combination could be useful in clinical applications.
A New Myohaptic Instrument to Assess Wrist Motion Dynamically

The pathophysiological assessment of joint properties and voluntary motion in neurological patients remains a challenge. This is typically the case in cerebellar patients, who exhibit dysmetric movements due to the dysfunction of cerebellar circuitry. Several tools have been developed, but so far most of these tools have remained confined to laboratories, with a lack of standardization. We report on a new device which combines the use of electromyographic (EMG) sensors with haptic technology for the dynamic investigation of wrist properties. The instrument is composed of a drivetrain, a haptic controller and a signal acquisition unit. Angular accuracy is 0.00611 rad, nominal torque is 6 N·m, maximal rotation velocity is 34.907 rad/sec, with a range of motion of −1.0472 to +1.0472 rad. The inertia of the motor and handgrip is 0.004 kg·m2. This is the first standardized myohaptic instrument allowing the dynamic characterization of wrist properties, including under the condition of artificial damping. We show that cerebellar patients are unable to adapt EMG activities when faced with an increase in damping while performing fast reversal movements. The instrument allows the extraction of an electrophysiological signature of a cerebellar deficit.
High injury incidence in TeamGym competition: a prospective cohort study

TeamGym is a relative new form of gymnastics originating from Scandinavia. Little is known regarding injury incidence and injury types. The aim of this study was to examine the injury pattern and incidence in Norwegian TeamGym competition. The study is a prospective cohort, with one 10‐month season [17 competitions, n=8418 athlete‐exposures (A‐Es), a total of 1134 h of exposure]. Injury pattern, incidence and exposure during competition were collected using an injury registration form. During the competitions, 115 injuries were reported including 49 (43%) acute injuries, 58 (50%) exacerbations and eight (7%) re‐injuries. The injury incidence was 50.3/1000 h or 6.8/1000 A‐Es. Ankle injuries accounted for 25.6/1000 h. A total number of 30 time‐loss injuries were found, giving 27 injuries per 1000 h. The high proportion of exacerbations shows that the gymnasts competed even if they had not recovered fully from previous overuse or acute injuries. A higher injury rate was observed in competition than during the pre‐competition apparatus warm‐up. Eighty‐four per cent of the injuries occurred in the landing phase of the gymnastic skill. No sex differences were observed. The injury rate in Norwegian TeamGym competition is high, in particular for ankle injuries.
Bayesian inference using data flow analysis

We present a new algorithm for Bayesian inference over probabilistic programs, based on data flow analysis techniques from the program analysis community. Unlike existing techniques for Bayesian inference on probabilistic programs, our data flow analysis algorithm is able to perform inference directly on probabilistic programs with loops. Even for loop-free programs, we show that data flow analysis offers better precision and better performance benefits over existing techniques. We also describe heuristics that are crucial for our inference to scale, and present an empirical evaluation of our algorithm over a range of benchmarks.
Remote sensing of soot carbon – Part 1: Distinguishing different absorbing aerosol species

Abstract. We describe a method of using the Aerosol Robotic Network (AERONET) size distributions and complex refractive indices to retrieve the relative proportion of carbonaceous aerosols and free iron minerals (hematite and goethite). We assume that soot carbon has a spectrally flat refractive index and enhanced imaginary indices at the 440 nm wavelength are caused by brown carbon or hematite. Carbonaceous aerosols can be separated from dust in imaginary refractive index space because 95 % of biomass burning aerosols have imaginary indices greater than 0.0042 at the 675–1020 nm wavelengths, and 95 % of dust has imaginary refractive indices of less than 0.0042 at those wavelengths. However, mixtures of these two types of particles can not be unambiguously partitioned on the basis of optical properties alone, so we also separate these particles by size. Regional and seasonal results are consistent with expectations. Monthly climatologies of fine mode soot carbon are less than 1.0 % by volume for West Africa and the Middle East, but the southern African and South American biomass burning sites have peak values of 3.0 and 1.7 %. Monthly averaged fine mode brown carbon volume fractions have a peak value of 5.8 % for West Africa, 2.1 % for the Middle East, 3.7 % for southern Africa, and 5.7 % for South America. Monthly climatologies of free iron volume fractions show little seasonal variability, and range from about 1.1 to 1.7 % for coarse mode aerosols in all four study regions. Finally, our sensitivity study indicates that the soot carbon retrieval is not sensitive to the component refractive indices or densities assumed for carbonaceous and free iron aerosols, and the retrieval differs by only 15.4 % when these parameters are altered from our chosen baseline values. The total uncertainty of retrieving soot carbon mass is ∼ 50 % (when uncertainty in the AERONET product and mixing state is included in the analysis).
Performance evaluation of objective quality metrics for HDR image compression

Due to the much larger luminance and contrast characteristics of high dynamic range (HDR) images, well-known objective quality metrics, widely used for the assessment of low dynamic range (LDR) content, cannot be directly applied to HDR images in order to predict their perceptual fidelity. To overcome this limitation, advanced fidelity metrics, such as the HDR-VDP, have been proposed to accurately predict visually significant differences. However, their complex calibration may make them difficult to use in practice. A simpler approach consists in computing arithmetic or structural fidelity metrics, such as PSNR and SSIM, on perceptually encoded luminance values but the performance of quality prediction in this case has not been clearly studied. In this paper, we aim at providing a better comprehension of the limits and the potentialities of this approach, by means of a subjective study. We compare the performance of HDR-VDP to that of PSNR and SSIM computed on perceptually encoded luminance values, when considering compressed HDR images. Our results show that these simpler metrics can be effectively employed to assess image fidelity for applications such as HDR image compression.