Miracle-dz/UniFAR-FTUs huggingface dataset:
Modelling Intra- and Extra-Area Trade Substitution and Exchange Rate Pass-Through in the Euro Area

The paper proposes a modelling approach for euro area goods and services trade volumes and prices on the basis of a break-down of trade data into their intra- and extra-area components. Using the evidence from the newly estimated trade equations, the paper gives new insights into two important issues. The first issue concerns the exchange-rate pass-through (ERPT) to euro area import prices. The second issue relates to substitution effects between intra- and extra-area trade. These issues are further elaborated through simulation analyses using the ECB’s area-wide model (AWM). The simulations illustrate the impact of external and domestic shocks to trade in the euro area, in particular on intra- and extra-area trade. The richer dynamics from this disaggregated perspective provide additional insights and elucidate transmission channels of shocks that are not detectable from an aggregate (i.e. total trade) perspective. For instance, one interesting finding is that an appreciation of the euro has a significant downward impact on intra euro area trade. JEL Classification: E31, F17, C5
The Determinants of Capital Held by UK Banks and Building Societies and the Role of Individual Capital Requirements

The globalisation of financial markets has attracted much academic and policymaking commentary in recent years, especially with the growing number of banking and financial crises and the current credit crisis that has threatened the stability of the global financial system. This major Research Handbook sets out to address some of the fundamental issues in financial regulation from a comparative and international perspective and to identify some of the main research themes and approaches that combine economic, legal and institutional analysis of financial markets.
The Elusive Basis of Legitimacy in Global Governance: Three Conceptions

The Elusive Basis of Legitimacy in Global Governance: Three Conceptions How to create and maintain legitimacy is arguably the greatest contemporary challenge to global governance and international order. To address this challenge, International Relations scholars, accustomed to a clear distinction between international and domestic legitimacy, have had to borrow extensively from the fields of political philosophy, comparative politics, law, and sociology, which have long investigated the legitimate basis of political authority. These traditions inform three distinct conceptions of legitimacy in this new wave of scholarship: 1) principled legitimacy rooted in democratic politics; 2) legitimacy as law or legalization; and 3) a sociological conception of legitimacy rooted in intersubjective beliefs about appropriateness. Each conception provides only partial insight into the core puzzle animating this literature: what does political authority beyond the state require? The answer can only be found through an examination of the relationship of power, legitimacy, and community, which together constitute political authority. This is a revised version of a paper first presented at the annual meeting of the American Political Science Association, San Francisco, August 29-September 1, 2001. I thank Benjamin Cashore, Catherine Connors, Erin Hannah, Louis Pauly, Grace Skogstad, Janice Stein, Alexander Wendt, and Linda White for comments and criticisms and Catherine Connors and Erin Hannah for valuable research assistance. I also gratefully acknowledge financial support from the Social Sciences and Humanities Research Council of Canada. The Elusive Basis of Legitimacy in Global Governance: Three Conceptions Steven Bernstein, University of Toronto
Modulating Activity of Vancomycin and Daptomycin on the Expression of Autolysis Cell-Wall Turnover and Membrane Charge Genes in hVISA and VISA Strains

Glycopeptides are still the gold standard to treat MRSA (Methicillin Resistant Staphylococcus aureus) infections, but their widespread use has led to vancomycin-reduced susceptibility [heterogeneous Vancomycin-Intermediate-Staphylococcus aureus (hVISA) and Vancomycin-Intermediate-Staphylococcus aureus (VISA)], in which different genetic loci (regulatory, autolytic, cell-wall turnover and cell-envelope positive charge genes) are involved. In addition, reduced susceptibility to vancomycin can influence the development of resistance to daptomycin. Although the phenotypic and molecular changes of hVISA/VISA have been the focus of different papers, the molecular mechanisms responsible for these different phenotypes and for the vancomycin and daptomycin cross-resistance are not clearly understood. The aim of our study was to investigate, by real time RT-PCR, the relative quantitative expression of genes involved in autolysis (atl-lytM), cell-wall turnover (sceD), membrane charges (mprF-dltA) and regulatory mechanisms (agr-locus-graRS-walKR), in hVISA and VISA cultured with or without vancomycin and daptomycin, in order to better understand the molecular basis of vancomycin-reduced susceptibility and the modulating activity of vancomycin and daptomycin on the expression of genes implicated in their reduced susceptibility mechanisms. Our results show that hVISA and VISA present common features that distinguish them from Vancomycin-Susceptible Staphylococcus aureus (VSSA), responsible for the intermediate glycopeptide resistance i.e. an increased cell-wall turnover, an increased positive cell-wall charge responsible for a repulsion mechanism towards vancomycin and daptomycin, and reduced agr-functionality. Indeed, VISA emerges from hVISA when VISA acquires a reduced autolysis caused by a down-regulation of autolysin genes, atl/lytM, and a reduction of the net negative cell-envelope charge via dltA over-expression. Vancomycin and daptomycin, acting in a similar manner in hVISA and VISA, can influence their cross-resistance mechanisms promoting VISA behavior in hVISA and enhancing the cell-wall pathways responsible for the intermediate vancomycin resistance in VISA. Daptomycin can also induce a charge repulsion mechanism both in hVISA and VISA increasing the activity of the mprF.
VEGF Receptor-2 (Flk-1) Overexpression in Mice Counteracts Focal Epileptic Seizures

Vascular endothelial growth factor (VEGF) was first described as an angiogenic agent, but has recently also been shown to exert various neurotrophic and neuroprotective effects in the nervous system. These effects of VEGF are mainly mediated by its receptor, VEGFR-2, which is also referred to as the fetal liver kinase receptor 1 (Flk-1). VEGF is up-regulated in neurons and glial cells after epileptic seizures and counteracts seizure-induced neurodegeneration. In vitro, VEGF administration suppresses ictal and interictal epileptiform activity caused by AP4 and 0 Mg2+ via Flk-1 receptor. We therefore explored whether increased VEGF signaling through Flk-1 overexpression may regulate epileptogenesis and ictogenesis in vivo. To this extent, we used transgenic mice overexpressing Flk-1 postnatally in neurons. Intriguingly, Flk-1 overexpressing mice were characterized by an elevated threshold for seizure induction and a decreased duration of focal afterdischarges, indicating anti-ictal action. On the other hand, the kindling progression in these mice was similar to wild-type controls. No significant effects on blood vessels or glia cells, as assessed by Glut1 and GFAP immunohistochemistry, were detected. These results suggest that increased VEGF signaling via overexpression of Flk-1 receptors may directly affect seizure activity even without altering angiogenesis. Thus, Flk-1 could be considered as a novel target for developing future gene therapy strategies against ictal epileptic activity.
Distinct phenotypes of speech and voice disorders in Parkinson's disease after subthalamic nucleus deep brain stimulation

Objectives To elucidate the phenotypes and pathophysiology of speech and voice disorders in Parkinson's disease (PD) with subthalamic nucleus deep brain stimulation (STN-DBS). Methods We conducted a cross-sectional study on 76 PD patients treated with bilateral STN-DBS (PD-DBS) and 33 medically treated PD patients (PD-Med). Speech and voice functions, electrode positions, motor function and cognitive function were comprehensively assessed. Moreover, speech and voice functions were compared between the on-stimulation and off-stimulation conditions in 42 PD-DBS patients. Results Speech and voice disorders in PD-DBS patients were significantly worse than those in PD-Med patients. Factor analysis and subsequent cluster analysis classified PD-DBS patients into five clusters: relatively good speech and voice function type, 25%; stuttering type, 24%; breathy voice type, 16%; strained voice type, 18%; and spastic dysarthria type, 17%. STN-DBS ameliorated voice tremor or low volume; however, it deteriorated the overall speech intelligibility in most patients. Breathy voice did not show significant changes and stuttering exhibited slight improvement after stopping stimulation. In contrast, patients with strained voice type or spastic dysarthria type showed a greater improvement after stopping stimulation. Spastic dysarthria type patients showed speech disorders similar to spastic dysarthria, which is associated with bilateral upper motor neuron involvement. Strained voice type and spastic dysarthria type appeared to be related to current diffusion to the corticobulbar fibres. Conclusions Stuttering and breathy voice can be aggravated by STN-DBS, but are mainly due to aging or PD itself. Strained voice and spastic dysarthria are considered corticobulbar side effects.
Experiences in database system implementation using a persistent programming language

The EXODUS database toolkit, and in particular the E persistent programming language, have been used in two substantial database system implementation efforts by the authors, the Ariel database rule system and the Triton nested relation DBMS. An important advantage of using a persistent programming language for database system implementation is that it is easy to implement special‐purpose persistent objects used by the DBMS such as catalogs, rule indexes, and nested relational structures. Support for transactions built into a persistent programming language greatly reduces the effort required to implement a database system. A disadvantage observed is that it is not possible to map the type system of the DBMS to the type system of the underlying programming language while still retaining good performance for ad hoc queries. Also, software engineering difficulties arise when a persistent language makes a distinction between database types and main‐memory types.
Commodity prices and inflation

This study examines the empirical relationship between changes in commodity prices and inflation by looking at the performance of non-oil commodity prices as stand-alone indicators of inflation and in conjunction with other leading indicators of inflation. The results indicate that the empirical link between commodity prices and inflation has changed dramatically over time. Commodity prices were relatively strong and statistically robust leading indicators of overall inflation during the 1970s and early 1980s, but they have been poor stand-alone indicators of inflation since the early 1980s. When considered in conjunction with other likely indicators of inflation, non-oil commodity prices have had a somewhat more statistically robust relationship with inflation in recent years, though the added information content in commodity prices regarding inflation is limited. (This abstract was borrowed from another version of this item.)
Momentum and Default Risk: Some Results Using the Jump Component

In this paper we separate the total stock return into its continuous and jump component to test whether stock return predictability should be attributed to omitted risk factors or behavioral finance theories. We extend results from the US market to the Spanish stock market, which, despite being a developed market, presents several differences in terms of stock characteristics, financial system, investor typology and cultural dimensions. The results show that the jump component has significant explanatory power for the premium of three characteristics (size, book-to-market and illiquidity), which is at odds with risk-based explanations. Using the same testing strategy, we try to shed some light on an important controversy concerning the relationship between default risk and momentum. The results suggest that default risk is not the source of momentum returns.
Fundamental solutions and mapping properties of semielliptic operators

An explicit formula is given for a fundamental solution for a class of semielliptic operators. The fundamental solution is used to investigate properties of these operators as mappings between weighted function spaces in ℝn . Necessary and sufficient conditions are given for such a mapping to be an isomorphism. Results apply, for example, to elliptic, parabolic, and generalized p ‐parabolic operators. (© 2006 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Indirect test architecture for SoC testing

A generic model for test architectures in the core-based system-on-chip (SoC) designs consists of source/sink, wrapper, and test access mechanism (TAM). Current test architectures for digital cores assume a direct connection between the core and the tester. In these architectures, the tester establishes a physical link between itself and the core, such that it can directly control the core's design-for-testability (DFT), such as the scan chains or primary inputs. This direct connection undermines the modularity in the generic test architecture by tightly coupling its elements. In this paper, we propose a network-oriented indirect and modular architecture (NIMA) for postfabrication test in an SoC design methodology. In NIMA, test stimuli and expected results for digital cores are first compiled into new formats and subsequently encapsulated into packets. These packets are augmented with control and address bits such that they can autonomously be transmitted to their destination through a switching fabric. Owing to the indirect nature of the connection, embedded autonomous blocks at each core are used to apply the test to the core and compare the test results with expected values. This indirect access to the core decouples test data processing at the core from its communication providing the basis for flexible and modular test design and programming. Moreover, NIMA facilitates remote-access of single or multiple testers to an SoC, and enables the sending of test data to an SoC in-field in order to test the chip in its target system. Finally, NIMA serves in contributing toward the development of new test architectures that benefit from network-centric SoCs. We present a first implementation of NIMA when applied to a number of SoC benchmarks.
Calpain‐mediated cleavage of collapsin response mediator protein(CRMP)‐2 during neurite degeneration in mice

Axon or dendrite degeneration involves activation of the ubiquitin–proteasome system, failure to maintain neuritic ATP levels, microtubule fragmentation and a mitochondrial permeability transition that occur independently of the somal death programs. To gain further insight into the neurite degeneration mechanims we have compared two‐dimensional gel electrophoresis patterns of neurite proteins from suprior cervical ganglia during degeneration caused by nerve growth factor (NGF) deprivation. We show here that collapsin response mediator protein (CRMP)‐2 and CMRP‐4 protein patterns were altered during beading formation, an early hallmark of neurite degeneration, prior to neurite fragmentation, the final stage of degeneration. Western blotting using a monoclonal antibody against CRMP‐2 shows that the native form (64 kDa) was cleaved to generate a truncated form (58 kDa). No cleavage of CRMP‐2 or ‐4 occurred in NGF‐deprived neurites from Wld s (Wallerian degeneration slow) mutant mice in which neurite degeneration is markedly delayed. Using different protease inhibitors, purified calpain 1 protein and calpain 1‐specific siRNA, we have demonstrated that CRMP‐2 is a substrate for calpain 1. Indeed, caplain activity was activated at an early phase of neuronal degeneration in cerebellar granule neurons, and down‐regulation of caplain 1 expression suppressed CRMP‐2 cleavage. Furthermore, this cleavage occurred after vinblastine treatment or in vitro Wallerian degeneration, suggesting that it represents a common step in the process of dying neurites. CRMP‐2 and ‐4 play a pivotal role in axonal growth and transport, and the C‐terminus region of CRMP‐2 is essential for its binding to kinesin‐1. Hence, this cleavage will render them dysfunctional and subject to autophagic processing associated with beading formation, as evidenced by the finding that the truncated form was localized in the beadings.
‘Natural experiment’ Demonstrates Top-Down Control of Spiders by Birds on a Landscape Level

The combination of small-scale manipulative experiments and large-scale natural experiments provides a powerful approach for demonstrating the importance of top-down trophic control on the ecosystem scale. The most compelling natural experiments have come from studies examining the landscape-scale loss of apex predators like sea otters, wolves, fish and land crabs. Birds are dominant apex predators in terrestrial systems around the world, yet all studies on their role as predators have come from small-scale experiments; the top-down impact of bird loss on their arthropod prey has yet to be examined at a landscape scale. Here, we use a unique natural experiment, the extirpation of insectivorous birds from nearly all forests on the island of Guam by the invasive brown tree snake, to produce the first assessment of the impacts of bird loss on their prey. We focused on spiders because experimental studies showed a consistent top-down effect of birds on spiders. We conducted spider web surveys in native forest on Guam and three nearby islands with healthy bird populations. Spider web densities on the island of Guam were 40 times greater than densities on islands with birds during the wet season, and 2.3 times greater during the dry season. These results confirm the general trend from manipulative experiments conducted in other systems however, the effect size was much greater in this natural experiment than in most manipulative experiments. In addition, bird loss appears to have removed the seasonality of spider webs and led to larger webs in at least one spider species in the forests of Guam than on nearby islands with birds. We discuss several possible mechanisms for the observed changes. Overall, our results suggest that effect sizes from smaller-scale experimental studies may significantly underestimate the impact of bird loss on spider density as demonstrated by this large-scale natural experiment.
Generalized external interaction with tamper-resistant hardware with bounded information leakage

This paper investigates secure ways to interact with tamper-resistant hardware leaking a strictly bounded amount of information. Architectural support for the interaction mechanisms is studied and performance implications are evaluated. The interaction mechanisms are built on top of a recently-proposed secure processor Ascend[ascend-stc12]. Ascend is chosen because unlike other tamper-resistant hardware systems, Ascend completely obfuscates pin traffic through the use of Oblivious RAM (ORAM) and periodic ORAM accesses. However, the original Ascend proposal, with the exception of main memory, can only communicate with the outside world at the beginning or end of program execution; no intermediate information transfer is allowed. Our system, Stream-Ascend, is an extension of Ascend that enables intermediate interaction with the outside world. Stream-Ascend significantly improves the generality and efficiency of Ascend in supporting many applications that fit into a streaming model, while maintaining the same security level.Simulation results show that with smart scheduling algorithms, the performance overhead of Stream-Ascend relative to an insecure and idealized baseline processor is only 24.5%, 0.7%, and 3.9% for a set of streaming benchmarks in a large dataset processing application. Stream-Ascend is able to achieve a very high security level with small overheads for a large class of applications.
Does interpersonal behavior of psychotherapy trainees differ in private and professional relationships?

Aim: The present study aimed to evaluate the effect of trainees’ interpersonal behavior on work involvement (WI) and compared their social behavior within professional and private relationships as well as between different psychotherapeutic orientations. Methods: The interpersonal scales of the Intrex short-form questionnaire and the Work Involvement Scale (WIS) were used to evaluate two samples of German psychotherapy trainees in psychoanalytic, psychodynamic, and cognitive behavioral therapy training. Trainees from Sample 1 (N = 184) were asked to describe their interpersonal behavior in relation to their patients when filling out the Intrex, whereas trainees from Sample 2 (N = 135) were asked to describe the private relationship with a significant other. Results: Interpersonal affiliation in professional relationships significantly predicted the level of healing involvement, while stress involvement was predicted by interpersonal affiliation and interdependence in trainees’ relationships with their patients. Social behavior within professional relationships provided higher correlations with WI than private interpersonal behavior. Significant differences were found between private and professional relation settings in trainees’ interpersonal behavior with higher levels of affiliation and interdependence with significant others. Differences between therapeutic orientation and social behavior could only be found when comparing trainees’ level of interdependence with the particular relationship setting. Conclusion: Trainees’ interpersonal level of affiliation in professional relationships is a predictor for a successful psychotherapeutic development. Vice versa, controlling behavior in professional settings can be understood as a risk factor against psychotherapeutic growth. Both results strengthen an evidence-based approach for competence development during psychotherapy training.
The Implicit Convex Feasibility Problem and Its Application to Adaptive Image Denoising

The implicit convex feasibility problem attempts to find a point in the intersection of a finite family of convex sets, some of which are not explicitly determined but may vary. We develop simultaneous and sequential projection methods capable of handling such problems and demonstrate their applicability to image denoising in a specific medical imaging situation. By allowing the variable sets to undergo scaling, shifting and rotation, this work generalizes previous results wherein the implicit convex feasibility problem was used for cooperative wireless sensor network positioning where sets are balls and their centers were implicit.
In Search of Possible Associations between Planetary Nebulae and Open Clusters

We consider the possibility of cluster membership for 13 planetary nebulae that are located in close proximity to open clusters lying in their lines of sight. The short lifetimes and low sample size of intermediate-mass planetary nebulae with respect to nearby open clusters conspire to reduce the probability of observing a true association. Not surprisingly, line-of-sight coincidences almost certainly exist for 7 of the 13 cases considered. Additional studies are advocated, however, for six planetary nebula/open cluster coincidences in which a physical association is not excluded by the available evidence, namely M 1-80/Berkeley 57, NGC 2438/NGC 2437, NGC 2452/NGC 2453, VBRC 2 and NGC 2899/IC 2488, and HeFa 1/NGC 6067. A number of additional potential associations between planetary nebulae and open clusters are tabulated for reference purposes. It is noteworthy that the strongest cases involve planetary nebulae lying in cluster coronae, a feature also found for short-period cluster Cepheids, which are themselves potential progenitors of planetary nebulae.