Miracle-dz/UniFAR-FTUs huggingface dataset:
Practical issues in medication compliance in hypertensive patients

Unsatisfactory compliance in the treatment of high blood pressure is frequently due to sequential barriers, such as insufficient patient education about the illness and low motivation to receive any treatment, existence of a large gap between physicians' perceptions of the problem and clinical reality, complexity of the treatment potentially generating adverse effects, and a health care environment with few public education campaigns and incentives for better coordi- nated supportive care. In order to improve drug compliance, establishment of personalized plans adapted to each patient is required. First, a good doctor-patient relationship is mandatory, with regular education of the patient about hypertension and its risks, discussion about adverse drug effects, and the complexity and cost of treatment. Second, to have any chance of success, the provider should offer convenient appointments and tailor the treatment regimen to the patient's lifestyle and needs, with written instructions. Third, there is a need to promote active patient collaboration with treatment. An innovative combination of home self-measurement of blood pressure, use of new technology options, eg, texting or telemedicine, and creation of a multi- disciplinary working team can offer new, effective opportunities. This approach could reduce cardiovascular complications by improving the control of high blood pressure, and thereby the overall costs of hypertension to the health care system.
Clinical Ophthalmology Dovepress Frequency and Risk Factors Associated with Dry Eye in Patients Attending a Tertiary Care Ophthalmology Center in Mexico City

hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms 1 everardo hernández-Quintela 1 1 Cornea and external Diseases service, asociación Para evitar la Ceguera en Mexico (association to prevent blindness in Mexico), Purpose: The purpose of this study was to ascertain the frequency and risk factors of dry eye (DE) among patients attending a tertiary care ophthalmology center in Mexico. Methods: Approximately 338 consecutive new patients attending a tertiary care ophthalmol-ogy center in Mexico City underwent an ocular surface examination, which included tear film break-up time, fluorescein corneal staining, Schirmer's test, and evaluation of meibum quality. Symptoms of DE were evaluated by the Ocular Surface Disease Index and Dry Eye Questionnaire-5. Information on demographics, exposures, past medical and ocular history, and medications was also collected. Results: The frequency of severe DE symptoms was found to be 43% based on the Ocular Surface Disease Index and 30% based on Dry Eye Questionnaire-5. Risk factors significantly associated with increased DE symptoms included dry mouth and gastrointestinal ulcer medications. With regard to signs, aqueous tear deficiency was a less-frequent finding (22%) in our population than evaporative deficiency (94%). Risk factors associated with aqueous tear deficiency were dry mouth and diuretic use. No risk factors were associated with evaporative deficiency. Risk factors associated with meibomian gland dysfunction included old age, male sex, arthritis, and use of an antihypertensive. The only risk factor associated with corneal staining was dry mouth. Conclusion: This is the first study to demonstrate the frequency of symptomatic and clinical DE in a tertiary care ophthalmology center in Mexico. The frequency of DE ranged from 30% using a symptomatic definition to 94% using objective measures. Different risk factors were found for different aspects of DE, suggesting differing underlying pathophysiologies behind different DE subtypes.
Endoscopic Band Ligation of Esophageal Varices in Patients on Anticoagulation

Endoscopic band ligation is an effective technique for primary and secondary prevention of gastro-esophageal variceal bleeding (GEVB), but can also result in rebleeding from postbanding ulcers. Its use in primary and secondary prevention of GEVB in anticoagulated patients has not been systematically studied. The aim of the study was to evaluate the feasibility of band ligation in primary and secondary prevention of GEVB in anticoagulated patients. Five patients (age 60.2±7.3 SD years: 3 males, 2 females) with esophageal varices on anticoagulation were studied using a retrospective chart review in a tertiary hospital setting. Patients were on mandatory anticoagulation with warfarin (international normalized ratio >2), on nonselective β-blocker therapy if tolerated and were not transvenous intrahepatic porto-systemic shunting candidates. One patient had polycythemia vera (noncirrhotic), the rest were cirrhotics Child class B/C (1 cardiogenic, 1 primary sclerosing cholangitis, 1 Budd-Chiari, and 1 cryptogenic cirrhosis). Two patients had experienced prior acute GEVB; band ligation performed during acute bleeding was not included in the study. All patients had at least grade III-IV esophageal varices on outpatient follow-up for band ligation. Three bands were placed/patient and study patients underwent 3 banding sessions on an average. None of the patients developed GEVB after band ligation. In 3 patients banding resulted in complete variceal eradication, the remaining 2 are still being followed-up for outpatient band ligation. In conclusion, this case series suggests that endoscopic band ligation can potentially be used in anticoagulated patients without alternatives for prevention of acute GEVB.
Pilot study: a randomised, double blind, placebo controlled trial of pancrealipase for the treatment of postprandial irritable bowel syndrome-diarrhoea

Objective To evaluate the efficacy of pancrealipase (PEZ) compared with placebo in the reduction of postprandial irritable bowel syndrome-diarrhoea (IBS-D). Design An intention to treat, double blind, randomised, crossover trial comparing PEZ to placebo for reduction of postprandial IBS-D. Patients had to recognise at least two different triggering foods, be willing to consume six baseline ‘trigger meals’ and again blinded with PEZ and placebo. Patients then chose which drug they preferred for another 25 meals. Setting Outpatient internal medicine practice clinic. Patients 255 patients were screened; 83 met the criteria, including 5 years of symptoms, recognised ‘food triggers’, no other identifiable cause for the symptoms, either a normal colonoscopy or barium enema while symptomatic and able to discontinue all anticholinergic medications. 69 patients were enrolled, 20 withdrew before randomisation, leaving 49 patients: 14 men, 35 women, mean age 52 years (SD 15.3). Over 60% had experienced symptoms for 11–30 years and 16% for more than 40 years. Interventions After completing six baseline meals, patients were randomised in blocks of four to receive either identical PEZ or a placebo for another six meals, and after a washout period of time received the alternative drug. Main outcome measures The primary analysis was number of patients who chose PEZ over placebo for the extended use. Results Overall, 30/49 (61%) would have chosen PEZ (p=0.078), with first drug preference for PEZ at 0.002. Among the PEZ subgroup, PEZ use compared with placebo, demonstrated improvement in all symptoms (p≤0.001) for cramping, bloating, borborygami, urge to defecate, global pain and decrease stooling with increase in stool firmness. Conclusions PEZ was found in a small group of patients to reduce postprandial IBS-D symptoms and deserves further evaluation.
BDNF diminishes caspase-2 but not c-Jun immunoreactivity of neurons in retinal ganglion cell layer after transient ischemia.

PURPOSE Retinal ischemia-reperfusion injury induces apoptosis of retinal neurons. The purpose of this study was to examine the association of c-Jun, caspase-1, -2, and -3 immunoreactivities and neuronal apoptosis in the retinal ganglion cell layer (GCL) and to study the effects of intravitreal brain-derived neurotrophic factor (BDNF) on the expression of these gene products in a rat model of retinal ischemia-reperfusion injury. METHODS After 60 minutes of ischemia, eyes were enucleated after 3, 6, 12, 24, and 168 hours of reperfusion. The numbers of c-Jun-, caspase-1-, caspase-2-, caspase-3, and TdT-dUTP terminal nick-end labeling (TUNEL)-positive cells in the GCL were counted. Recombinant human BDNF (5 microg) or vehicle was injected intravitreally immediately after reperfusion. At 6, 24, and 168 hours, the numbers of immunoreactive cells in BDNF- and vehicle-treated groups were compared. RESULTS Expression of c-Jun and caspase-2 was found in dying cells in flat-mounted retinas. The numbers of caspase-1- and caspase-3-positive cells were fewer than c-Jun- or caspase-2-positive cells. Cell death in the retinal GCL was suppressed by an intravitreal injection of BDNF. The numbers of TUNEL- and caspase-2-positive cells were lower in the BDNF-treated group at 6 hours after reperfusion (P<0.01). The number of c-Jun-positive cells in the treated retinas was not altered by the treatment. CONCLUSIONS Expression of c-Jun and caspase-2 is associated with neuronal cell apoptosis in the GCL. Suppression of caspase-2 expression may explain the neuroprotective effects of BDNF.
Where Do We Find Services in Enterprise Architectures? A Comparative Approach

In recent years, enterprise architecture (EA) has captured growing attention as a means to systematically consolidate and interrelate diverse IT artefacts in order to provide holistic decision support. Since the emergence of Service-Oriented Architecture (SOA), many attempts have been made to incorporate SOA artefacts in existing EA frameworks. Yet the approaches taken to achieve this goal differ substantially for the most commonly used EA frameworks to date. This paper investigates and compares five widely used EA frameworks in the way they embrace the SOA paradigm. It identifies what SOA artefacts are considered to be in the respective EA frameworks and their relative position in the overall structure. The results show that services and related artefacts are far from being well-integrated constructs in current EA frameworks. The comparison presented in this paper will support practitioners in identifying an EA framework that provides SOA support in a way that matches their requirements and will hopefully inspire the academic EA and SOA communities to work on a closer integration of these architectures.
Instruction Issue Logic in Pipelined Supercomputers

Basic principles and design tradeoffs for control of pipelined processors are first discussed. We concentrate on register-register architectures like the CRAY-1 where pipeline control logic is localized to one or two pipeline stages and is referred to as "instruction issue logic. " Design tradeoffs are explored by giving designs for a variety of instruction issue methods that represent a range of complexity and sophistication. These vary from the CRAY-1 issue logic to a version of Tomasulo's algorithm, first used in the IBM 360/91 floating point unit. Also studied are Thornton's "scoreboard" algorithm used on the CDC 6600 and an algorithm we have devised. To provide a standard for comparison, all the issue methods are used to implement the CRAY-1 scalar architecture. Then, using a simulation model and the Lawrence Livermore Loops compiled with the CRAY Fortran compiler, performance results for the various issue methods are given and discussed.
Immunological dissection of human Ia molecules

The immunochemical analysis of Daudi Ia molecules by a variety of alloantisera led to the recognition of at least three molecular species carrying different antigenic determinants: DRw6, DC-1, and DC-2. Genetic as well as structural evidence indicates that DRw6 and DC-1 molecules are controlled by separate, HLA-linked loci, rather than by alleles at the same locus. The alloantigenic determinants appear to be expressed on the small Ia subunit. DC-1 and DC-2 determinants discussed had not been defined by serological analysis at the population level, but were demonstrated to be present by immunochemical analysis at the molecular level.
CALL FOR PAPERS Cardiovascular Responses to Environmental Stress Cardiovascular response to thermoregulatory challenges

response growing number of extreme climate events are occurring in the setting of ongoing climate change, with an increase in both the intensity and frequency. It has been shown that ambient temperature challenges have a direct and highly varied impact on cardiovascular health. With a rapidly growing amount of literature on this issue, we aim to review the recent publications regarding the impact of cold and heat on human populations with regard to cardiovascular disease (CVD) mortality/morbidity while also examining lag effects, vulnerable subgroups, and relevant mechanisms. Although the relative risk of morbidity/mortality associated with extreme temperature varied greatly across different studies, both cold and hot temper- atures were associated with a positive mean excess of cardiovascular deaths or hospital admissions. Cause-speciﬁc study of CVD morbidity/mortality indicated that the sensi- tivity to temperature was disease-speciﬁc, with different patterns for acute and chronic ischemic heart disease. Vulnerability to temperature-related mortality was associated with some characteristics of the populations, including sex, age, location, socioeconomic condition, and comorbidities such as cardiac diseases, kidney diseases, diabetes, and hypertension. Temperature-induced damage is thought to be related to enhanced sympathetic reactivity followed by activation of the sympathetic nervous system, renin-angiotensin system, as well as dehydration and a systemic inﬂammatory response. Future research should focus on multidisciplinary adaptation strategies that incorporate epidemiology, climatology, indoor/building environments, energy usage, labor legislative perfection, and human thermal comfort models. Studies on the underlying mech- anism by which temperature challenge induces pathophysiological response and CVD await profound and lasting investigation.
Analysis of the Security of BB84 by Model Checking

Quantum Cryptography or Quantum key distribution (QKD) is a technique that allows the secure distribution of a bit string, used as key in cryptographic protocols. When it was noted that quantum computers could break public key cryptosystems based on number theory extensive studies have been undertaken on QKD. Based on quantum mechanics, QKD offers unconditionally secure communication. Now, the progress of research in this field allows the anticipation of QKD to be available outside of laboratories within the next few years. Efforts are made to improve the performance and reliability of the implemented technologies. But several challenges remain despite this big progress. The task of how to test the apparatuses of QKD For example did not yet receive enough attention. These devises become complex and demand a big verification effort. In this paper we are interested in an approach based on the technique of probabilistic model checking for studying quantum information. Precisely, we use the PRISM tool to analyze the security of BB84 protocol and we are focused on the specific security property of eavesdropping detection. We show that this property is affected by the parameters of quantum channel and the power of eavesdropper.
In-situ x-ray scattering studies of Ag nano-structures

When metals are synthesized on the nanoscale, new physics can arise in the growth process as quantum confinement of the conduction electrons, known as quantum size effects, can lead to preferred heights of metallic nanoscale islands. Despite a significant amount of prior research, there has been a poor understanding of the growth behavior of the simple noble metal, Ag, on the Si(111)7x7 substrate and researchers have been unable to connect its growth morphology to quantum size effects. This dissertation investigated the growth of Ag on Si(111)7x7, in situ and in ultra-high vacuum, using synchrotron x-ray scattering. Because of the unique ability of this technique to explore the structure of a buried interface on the atomic scale, these studies led to a clear understanding of the role of quantum size effects in the growth behavior of this system. The studies address the epitaxial relationship between Ag and the substrate as well as the transition from the wetting layer to the growth of nanoscale islands. It is found that islands have a minimum thickness of three Ag atomic layers, which is in contrast to the bilayer on top of a wetting layer that has been reported in previous scanning tunneling microscopy studies. Ag islands are found to form after the completion of the Ag/Si(111)7x7 wetting layer and they convert the underlying wetting layer into the FCC structure of the island. The observed preference of the Ag islands is explained by the energy per area of the island, which derives from quantum confinement effects, and its two phase coexistence with the wetting layer. For thicker island heights, it is found that the distribution of island heights refl ect the minimum thickness of three layers. The height fluctuations are observed to exhibit a Poisson-like distribution where only the low heights in the fl uctuation spectrum deviate from a Poisson distribution. A model of the height distribution is presented. Techniques for exploring buried nanoscale vacancy defects in metals using diffuse x-ray scattering were also explored in this dissertation. Strain fields due to nanoscale vacancy clusters located below a surface were explored through analytical modeling of elastic displacements as well from results of accelerated molecular dynamics simulations. A method for numerically calculating diffuse scattering from nanoscale vacancy clusters was also explored. As new technologies continue to exploit thin-film metals on nanoscale dimensions, this investigation provides important new understanding about how metals grow on the nanoscale.
Modular Unipolar Versus Bipolar Prosthesis: A Prospective Evaluation of Functional Outcome After Femoral Neck Fracture

Summary: Between January 1, 1987, and December 31, 1992, 140 communitydwelling geriatric patients ≥65 years of age with a displaced femoral neck fracture (Garden III—IV) underwent primary prosthetic replacement and were followed prospectively for a minimum of 1 year. Overall, 92 patients received a cemented bipolar prosthesis and 48 patients received a cemented modular unipolar prosthesis. There were no statistically significant differences between the two groups with respect to preinjury characteristics (age, sex, and number and severity of medical comorbidities) and functional ability. There were no statistically significant differences between the two groups with regard to the number of postoperative complications, length of stay, and 1 year mortality rate. An in-depth functional evaluation was obtained as follows: level of ambulation, independence in basic activities of daily living (feeding, bathing, dressing, toileting), and independence in instrumental activities of daily living (food shopping, food preparation, banking, laundry, housework, and use of public transportation). At 1 year follow-up, no statistically significant differences in functional ability were identified between the unipolar and bipolar groups. Furthermore, at a minimum of 1 year follow-up, there were no statistically significant differences between the two groups with regard to the need for revision surgery or the incidence hip pain. Based on the results of this study, there does not appear to be any advantage to the use of bipolar endoprosthesis for the treatment of femoral neck fractures in the elderly patient. The lower cost of modular unipolar prostheses compared with bipolar prostheses provides additional support for their use
MAPK and pro-inflammatory mediators in the walls of brain blood vessels following cerebral ischemia

• Users may download and print one copy of any publication from the public portal for the purpose of private study or research. • You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal ? Take down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.
Akineto-rigid vs. tremor syndromes in Parkinsonism

Purpose of reviewAkinesia, rigidity and low-frequency rest tremor are the three cardinal motor signs of Parkinson's disease and some Parkinson's disease animal models. However, cumulative evidence supports the view that akinesia/rigidity vs. tremor reflect different pathophysiological phenomena in the basal ganglia. Here, we review the recent physiological literature correlating abnormal neural activity in the basal ganglia with Parkinson's disease clinical symptoms. Recent findingsThe subthalamic nucleus of Parkinson's disease patients is characterized by oscillatory activity in the beta-frequency (∼15 Hz) range. However, Parkinson's disease tremor is not strictly correlated with the abnormal synchronous oscillations of the basal ganglia. On the other hand, akinesia and rigidity are better correlated with the basal ganglia beta oscillations. SummaryThe abnormal basal ganglia output leads to akinesia and rigidity. Parkinson's disease tremor most likely evolves as a downstream compensatory mechanism.
A Five-Day Progesterone Plus eCG-Based Fixed-Time AI Protocol Improves Fertility Over Spontaneous Estrus in High-Producing Dairy Cows Under Heat Stress

Abstract This study compared the efficiency of a five-day or standard (nine-day) progesterone-based regimen combined with equine chorionic gonadotrophin (eCG) in a fixed-time AI (FTAI) protocol for dairy cows. The data examined were derived from 3577 inseminations conducted in three dairy herds. Animals with no estrus signs detected over 21 days were randomly assigned to a PRID-9 or PRID-5 group. Cows in each group received a progesterone intravaginal device (PRID) for 9 or 5 days, respectively, PGF2α and eCG on PRID removal, and GnRH 48 h later. Fixed-time AI was performed 12 h after the GnRH dose. Cows artificially inseminated following spontaneous estrus during the study period were considered as controls. Based on the odds ratio, the likelihoods of animals in PRID-9 in the warm (conception rate [CR] of 22.3%) and cool (32% CR) periods, and control animals in the warm period (26.6% CR) becoming pregnant were reduced (by factors of 0.6, 0.3 and 0.4, respectively) compared with the control animals in the cool period (CR of 43.7%). The risk of a twin pregnancy was higher (51.4%) for cystic PRID-9 cows (by a factor of 3.6) and lower (9.9%) for cyclic PRID-5 animals (by a factor of 0.4) compared with the PRID-9 cyclic cows. These findings indicate that the proposed protocol achieves similar results during the cool or warm season to those obtained when AI is conducted at spontaneous estrus during the cool season. In addition, PRID-5 reduced twin pregnancy compared with PRID-9.