Miracle-dz/UniFAR-FTUs huggingface dataset:
Factors affecting patient reporting of adverse drug reactions: a systematic review

AIM The aim of the present study was to determine the barriers and motives influencing consumer reporting of adverse drug reactions (ADRs). METHODS A systematic review, guided by the Cochrane Handbook, was conducted. Electronic searches included MEDLINE, EMBASE, PsycINFO, CINAHL, PubMed and the Cochrane Database of Systematic Reviews from 1964 to December 2014. Eligible studies addressed patients' perceptions and factors influencing ADR reporting. Studies about healthcare professional (HCP) reporting of ADRs were excluded. Studies were appraised for quality, and results were analysed descriptively. RESULTS Of 1435 citations identified, 21 studies were eligible. Studies were primarily conducted in the UK, the Netherlands and Australia. The identified barriers to patient reporting of ADRs (n = 15 studies) included poor awareness, confusion about who should report the ADR, difficulties with reporting procedures, lack of feedback on submitted reports, mailing costs, ADRs resolved and prior negative reporting experiences. The identified motives for patients reporting ADRs (n = 10 studies) were: preventing others from having similar ADRs, wanting personal feedback, improving medication safety, informing regulatory agencies, improving HCP practices, responding to HCPs not reporting their ADRs and having been asked to report ADRs by HCPs. CONCLUSIONS Most patients were not aware of reporting systems and others were confused about reporting. Patients were mainly motivated to make their ADRs known to prevent similar suffering in other patients. By increasing patient familiarity and providing clear reporting processes, reporting systems could better achieve patient reporting of ADRs.
Fission yeast myosin Myo2 is down-regulated in actin affinity by light chain phosphorylation

Significance The separation of daughter cells during cell division, or cytokinesis, is a process that requires contractile rings which develop tension using actin and myosin. Current models of contractile ring dynamics are based on quantitative data from two decades of research using the tractable fission yeast system. However, it is unknown how fission yeast’s essential myosin, Myo2, is regulated in the contractile ring. Here, we find that Myo2 does not assemble into minifilaments, consistent with its role in ring precursor nodes. Unphosphorylated Myo2 exhibits robust enzymatic and motor activity whereas phosphorylation of Myo2’s regulatory light chain reduces its affinity for actin. This reduction likely weakens the tension in the contractile ring, potentially to delay cytokinesis until segregation of chromosomes is complete. Studies in fission yeast Schizosaccharomyces pombe have provided the basis for the most advanced models of the dynamics of the cytokinetic contractile ring. Myo2, a class-II myosin, is the major source of tension in the contractile ring, but how Myo2 is anchored and regulated to produce force is poorly understood. To enable more detailed biochemical/biophysical studies, Myo2 was expressed in the baculovirus/Sf9 insect cell system with its two native light chains, Rlc1 and Cdc4. Milligram yields of soluble, unphosphorylated Myo2 were obtained that exhibited high actin-activated ATPase activity and in vitro actin filament motility. The fission yeast specific chaperone Rng3 was thus not required for expression or activity. In contrast to nonmuscle myosins from animal cells that require phosphorylation of the regulatory light chain for activation, phosphorylation of Rlc1 markedly reduced the affinity of Myo2 for actin. Another unusual feature of Myo2 was that, unlike class-II myosins, which generally form bipolar filamentous structures, Myo2 showed no inclination to self-assemble at approximately physiological salt concentrations, as analyzed by sedimentation velocity ultracentrifugation. This lack of assembly supports the hypothesis that clusters of Myo2 depend on interactions at the cell cortex in structural units called nodes for force production during cytokinesis.
Second‐ to third‐trimester longitudinal growth assessment for prediction of small‐for‐gestational age and late fetal growth restriction

Detection of fetal growth restriction (FGR) remains poor and most screening strategies rely on cross‐sectional evaluation of fetal size during the third trimester. A longitudinal and individualized approach has been proposed as an alternative method of evaluation. The aim of this study was to compare second‐ to third‐trimester longitudinal growth assessment to cross‐sectional evaluation in the third trimester for the prediction of small‐for‐gestational age (SGA) and late FGR in low‐risk singleton pregnancy.
Effect of high-frequency repetitive transcranial magnetic stimulation on chronic central pain after mild traumatic brain injury: A pilot study.

OBJECTIVE Central pain can occur following traumatic brain injury, leading to poor functional recovery, limitation of activities of daily living, and decreased quality of life. The aim of this study was to determine whether high-frequency (10 Hz) repetitive transcranial magnetic stimulation, applied over the primary motor cortex of the affected hemisphere, can be used to manage chronic central pain after mild traumatic brain injury. DESIGN Prospective randomized feasibility study. METHODS Twelve patients with mild traumatic brain injury and chronic central pain were randomly assigned to transcranial magnetic stimulation (high-frequency stimulation, 10 sessions) or sham groups. Diffuse tensor tractography revealed partially injured spinothalamocortical tracts in all recruited patients. A numerical rating scale (NRS) was used to evaluate pain intensity during pre-treatment and immediately after the 5th transcranial magnetic stimulation session (post1), 10th transcranial magnetic stimulation session (post2), and 1 (post3), 2 (post4), and 4 weeks (post 5) after finishing treatment. Physical and mental health status were evaluated using the Short Form 36 Health Survey (SF-36), including physical and mental component scores (PCS, MCS). RESULTS The NRS score of the repetitive transcranial magnetic stimulation group was significantly lower than the sham group score at all clinical evaluation time-points during and after transcranial magnetic stimulation sessions. The transcranial magnetic stimulation group's SF-36 PCS score was significantly higher at post2, post3, post4, and post5 compared with the sham group. CONCLUSION High-frequency transcranial magnetic stimulation may be used to manage chronic central pain and improve quality of life in patients with mild traumatic brain injury. However, this is a pilot study and further research is needed.
Attentional Bias to Beauty with Evolutionary Benefits: Evidence from Aesthetic Appraisal of Landscape Architecture

Substantial evidence suggests that beauty is associated with the survival and reproduction of organisms. Landscape architecture is composed of a series of natural elements that have significant evolutionary implications. The present study used one pilot material ratings and three experiments to examine the mechanisms of aesthetic appraisals of landscape architecture. The results confirmed that landscape architecture elicited a sense of beauty and captured visual attention more easily than other types of architecture during explicit aesthetic rating task (Experiment 1) and implicit aesthetic perception task (dot-probe paradigm, Experiment 2). Furthermore, the spatial cueing paradigm revealed that response latencies were significantly faster for landscape architecture than non-landscape architecture on valid trials, but there was no significant difference in this contrast on invalid trials at 150-ms stimulus onset asynchrony (SOA, Experiment 3a). At 500-ms SOA (Experiment 3b), participants responded significantly faster for landscape architecture on valid trials, but reacted significantly slower for landscape architecture on invalid trials. The findings indicated that the beauty of landscape architecture can be perceived implicitly, and only faster orienting of attention, but not delayed disengagement of attention was generated at early stages of the processing of landscape architecture. However, the attentional bias at later stages of attentional processes may be resulted from both faster orienting of attention and delayed disengagement of attention from landscape architecture photographs.
Nutritive and Organoleptic Characteristics of Kilishi as Affected by Meat Type and Ingredient Formulation

Kilishi is a ready to eat intermediate moisture meat which is highly relished. The product is traditionally prepared from beef infused with spices and defatted groundnut paste. This study tried to appraise the eating quality of kilishi as affected by meat types and ingredient formulation.Three different kilishi recipes viz fresh, frozen and oven dried groundnut paste representing recipes 1, 2 and 3 respectively were formulated and used for the preparation of pork and beef kilishi in a completely randomized design. The nutrient composition and eating qualities of each kilishi type were evaluated. The result obtained showed that kilishi from the recipes were similar in crude protein with a value ranging from 55.47 – 62.33% while the ash content was highest (P>0.05) in beef kilishi from recipe 1. The colour rating was highest in all pork kilishi irrespective of the recipe. The panelist also rated pork kilishi higher in juiciness with a value range of 3.50 – 4.30 as against values of 1.80 – 4.40 for beef kilishi. Beef kilishi from recipe 1 had the highest flavour rating while the overall acceptability was highest in both products from recipe 1 with values of 6.30 and 5.20 for beef and pork kilishi respectively. The result obtained in this study showed that the use of recipe 1 with fresh groundnut paste was better in product qualities than frozen or oven dried groundnut paste.
Notch signaling and non-small cell lung cancer

Lung cancer is the leading cause of cancer-associated mortality worldwide. Elucidation of the pathogenesis and biology of lung cancer is critical for the design of an effective treatment for patients. Non-small cell lung cancer (NSCLC) accounts for 80–85% of lung cancer cases. The abnormal expression of Notch signaling pathway members is a relatively frequent event in NSCLC. The Notch signaling pathway serves important roles in cell fate determination, proliferation, differentiation and apoptosis. Increasing evidence supports the association of Notch signaling dysregulation with various types of malignant tumor, including NSCLC. Several studies have demonstrated that members of the Notch signaling pathway may be potential biomarkers for predicting the progression and prognosis of patients with NSCLC. Furthermore, Notch signaling serves critical roles in the tumorigenesis and treatment resistance of NSCLC cells by promoting the proliferation or inhibiting the apoptosis of NSCLC cells. The present review provides a detailed summary of the roles of Notch signaling in NSCLC.
Embodied meanings of early childbearing among American Indian women: a turning point.

INTRODUCTION American Indian women often have poor perinatal outcomes and are at risk for early childbearing. The purpose of this qualitative study was to understand the experience and meaning of early childbearing among American Indian women. METHODS Employing interpretive phenomenology and a semistructured interview guide, we interviewed 30 adult American Indian women residing in a northwestern American Indian reservation about their experiences and meaning of early childbearing. RESULTS Three overarching themes were tied to their eventual positive evaluation of the experience: 1) mourning a lost childhood, 2) seeking fulfillment, and 3) embodying responsibility. DISCUSSION Women indicated that despite their tumultuous childhoods, early childbearing presented an opportunity to effect positive change in their lives. Women's health care providers are positioned to help women change their lives, thereby, improving health outcomes.
Calcium Pumps and Interacting BON1 Protein Modulate Calcium Signature, Stomatal Closure, and Plant Immunity1[OPEN]

Calcium pumps ACA10 and ACA8 and their interacting protein BON1 regulate calcium signatures and impact stomatal movement and plant immunity in Arabidopsis. Calcium signaling is essential for environmental responses including immune responses. Here, we provide evidence that the evolutionarily conserved protein BONZAI1 (BON1) functions together with autoinhibited calcium ATPase10 (ACA10) and ACA8 to regulate calcium signals in Arabidopsis. BON1 is a plasma membrane localized protein that negatively regulates the expression of immune receptor genes and positively regulates stomatal closure. We found that BON1 interacts with the autoinhibitory domains of ACA10 and ACA8, and the aca10 loss-of-function (LOF) mutants have an autoimmune phenotype similar to that of the bon1 LOF mutants. Genetic evidences indicate that BON1 positively regulates the activities of ACA10 and ACA8. Consistent with this idea, the steady level of calcium concentration is increased in both aca10 and bon1 mutants. Most strikingly, cytosolic calcium oscillation imposed by external calcium treatment was altered in aca10, aca8, and bon1 mutants in guard cells. In addition, calcium- and pathogen-induced stomatal closure was compromised in the aca10 and bon1 mutants. Taken together, this study indicates that ACA10/8 and BON1 physically interact on plasma membrane and function in the generation of cytosol calcium signatures that are critical for stomatal movement and impact plant immunity.
Caregivers’ Impressions Predicting Fitness to Drive in Persons With Parkinson’s

Parkinson’s disease (PD) is a common neurodegenerative disease, increasing in incidence, with a known impact on fitness to drive. Although great progress has been made on evidence-based guidelines for assessing fitness to drive of persons with PD, a need remains for early identification of at-risk drivers in need of comprehensive assessment. This study investigated whether caregivers of drivers with PD could predict the driver’s on-road outcome. We also investigated whether the predictive value of their impressions differed from that of drivers themselves, their neurologist, or from information provided by standardized measures of visual and divided attention. Caregivers’ risk impressions (odds ratio [OR] = 13.76, p = .03) and Trail Making Test Part B (Trails B; OR = 0.41, p = .02) emerged as significant predictors of passing an on-road assessment. Our findings suggest that caregiver impressions, with a measure of set shifting, may be used as an efficient screen to identify drivers with PD who are potentially at risk for failing an on-road assessment.
The Application of EM38: Determination of Soil Parameters, Selection of Soil Sampling Points and Use in Agriculture and Archaeology

Fast and accurate assessment of within-field variation is essential for detecting field-wide heterogeneity and contributing to improvements in the management of agricultural lands. The goal of this paper is to provide an overview of field scale characterization by electromagnetic induction, firstly with a focus on the applications of EM38 to salinity, soil texture, water content and soil water turnover, soil types and boundaries, nutrients and N-turnover and soil sampling designs. Furthermore, results concerning special applications in agriculture, horticulture and archaeology are included. In addition to these investigations, this survey also presents a wide range of practical methods for use. Secondly, the effectiveness of conductivity readings for a specific target in a specific locality is determined by the intensity at which soil factors influence these values in relationship to the desired information. The interpretation and utility of apparent electrical conductivity (ECa) readings are highly location- and soil-specific, so soil properties influencing the measurement of ECa must be clearly understood. From the various calibration results, it appears that regression constants for the relationships between ECa, electrical conductivity of aqueous soil extracts (ECe), texture, yield, etc., are not necessarily transferable from one region to another. The modelling of ECa, soil properties, climate and yield are important for identifying the location to which specific utilizations of ECa technology (e.g., ECa−texture relationships) can be appropriately applied. In general, the determination of absolute levels of ECa is frequently not possible, but it appears to be quite a robust method to detect relative differences, both spatially and temporally. Often, the use of ECa is restricted to its application as a covariate or the use of the readings in a relative sense rather than as absolute terms.
Assessing the Utility of Low-Cost Particulate Matter Sensors over a 12-Week Period in the Cuyama Valley of California

The use of low-cost air quality sensors has proliferated among non-profits and citizen scientists, due to their portability, affordability, and ease of use. Researchers are examining the sensors for their potential use in a wide range of applications, including the examination of the spatial and temporal variability of particulate matter (PM). However, few studies have quantified the performance (e.g., accuracy, precision, and reliability) of the sensors under real-world conditions. This study examined the performance of two models of PM sensors, the AirBeam and the Alphasense Optical Particle Counter (OPC-N2), over a 12-week period in the Cuyama Valley of California, where PM concentrations are impacted by wind-blown dust events and regional transport. The sensor measurements were compared with observations from two well-characterized instruments: the GRIMM 11-R optical particle counter, and the Met One beta attenuation monitor (BAM). Both sensor models demonstrated a high degree of collocated precision (R2 = 0.8–0.99), and a moderate degree of correlation against the reference instruments (R2 = 0.6–0.76). Sensor measurements were influenced by the meteorological environment and the aerosol size distribution. Quantifying the performance of sensors in real-world conditions is a requisite step to ensuring that sensors will be used in ways commensurate with their data quality.
UvA-DARE ( Digital Academic Repository ) Updated cosmic-ray and radio constraints on light dark matter : Implications for the GeV gamma-ray excess at the Galactic Center

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Melanoma central nervous system metastases: current approaches, challenges, and opportunities

Melanoma central nervous system metastases are increasing, and the challenges presented by this patient population remain complex. In December 2015, the Melanoma Research Foundation and the Wistar Institute hosted the First Summit on Melanoma Central Nervous System (CNS) Metastases in Philadelphia, Pennsylvania. Here, we provide a review of the current status of the field of melanoma brain metastasis research; identify key challenges and opportunities for improving the outcomes in patients with melanoma brain metastases; and set a framework to optimize future research in this critical area.
Contribution of past and future self-defining event networks to personal identity

ABSTRACT Personal identity is nourished by memories of significant past experiences and by the imagination of meaningful events that one anticipates to happen in the future. The organisation of such self-defining memories and prospective thoughts in the cognitive system has received little empirical attention, however. In the present study, our aims were to investigate to what extent self-defining memories and future projections are organised in networks of related events, and to determine the nature of the connections linking these events. Our results reveal the existence of self-defining event networks, composed of both memories and future events of similar centrality for identity and characterised by similar identity motives. These self-defining networks expressed a strong internal coherence and frequently organised events in meaningful themes and sequences (i.e., event clusters). Finally, we found that the satisfaction of identity motives in represented events and the presence of clustering across events both contributed to increase in the perceived centrality of events for the sense of identity. Overall, these findings suggest that personal identity is not only nourished by representations of significant past and future events, but also depends on the formation of coherent networks of related events that provide an overarching meaning to specific life experiences.
Pn tomographic imaging of mantle lid velocity and anisotropy at the junction of the Arabian, Eurasian and African plates

An edited version of this paper was published by Blackwell Publishing in Geophysical Journal International. Copyright 2004, Blackwell Publishing. See also: http://www.blackwell-synergy.com/doi/abs/10.1111/j.1365-246X.2004. 02355.x; http://atlas.geo. cornell.edu/MiddleEastNorthAfrica/publications/Al-Lazki2004.htm
Facts and Misconceptions about 2D:4D, Social and Risk Preferences

We study how the ratio between the length of the second and fourth digit (2D:4D) correlates with choices in social and risk preferences elicitation tasks by building a large dataset from five experimental projects with more than 800 subjects. Our results confirm the recent literature that downplays the link between 2D:4D and many domains of economic interest, such as social and risk preferences. As for the former, we find that social preferences are significantly lower when 2D:4D is above the median value only for subjects with low cognitive ability. As for the latter, we find that a high 2D:4D is not correlated with the frequency of subjects' risky choices.
Medial Temporal Lobe Activity during Retrieval of Semantic Memory Is Related to the Age of the Memory

We measured brain activity using event-related fMRI as participants recalled answers to 160 questions about news events that had occurred during the past 30 years. Guided by earlier findings from patients with damage limited to the hippocampus who were given the same test material, we looked for regions that exhibited gradually decreasing activity as participants recalled memories from 1–12 years ago and a constant level of activity during recall of more remote memories. Regions in the medial temporal lobe exhibited a decrease in brain activity in relation to the age of the memory (hippocampus, temporopolar cortex, and amygdala). Regions in the frontal lobe, temporal lobe, and parietal lobe exhibited the opposite pattern. The findings for all of these regions were unrelated to the richness of the memories, to how well test questions were remembered later (encoding for subsequent memory), nor to how frequently semantic memories were accompanied by personal, episodic recollections. Last, activity in a different group of regions (perirhinal cortex, parahippocampal cortex, and inferior temporal gyrus) was associated with how well the test questions were subsequently remembered. The results support the idea that medial temporal lobe structures play a time-limited role in semantic memory.