Miracle-dz/UniFAR-FTUs huggingface dataset:
Integrating genome‐wide association study summaries and element‐gene interaction datasets identified multiple associations between elements and complex diseases

Chemical elements are closely related to human health. Extensive genomic profile data of complex diseases offer us a good opportunity to systemically investigate the relationships between elements and complex diseases/traits. In this study, we applied gene set enrichment analysis (GSEA) approach to detect the associations between elements and complex diseases/traits though integrating element‐gene interaction datasets and genome‐wide association study (GWAS) data of complex diseases/traits. To illustrate the performance of GSEA, the element‐gene interaction datasets of 24 elements were extracted from the comparative toxicogenomics database (CTD). GWAS summary datasets of 24 complex diseases or traits were downloaded from the dbGaP or GEFOS websites. We observed significant associations between 7 elements and 13 complex diseases or traits (all false discovery rate (FDR) < 0.05), including reported relationships such as aluminum vs. Alzheimer's disease (FDR = 0.042), calcium vs. bone mineral density (FDR = 0.031), magnesium vs. systemic lupus erythematosus (FDR = 0.012) as well as novel associations, such as nickel vs. hypertriglyceridemia (FDR = 0.002) and bipolar disorder (FDR = 0.027). Our study results are consistent with previous biological studies, supporting the good performance of GSEA. Our analyzing results based on GSEA framework provide novel clues for discovering causal relationships between elements and complex diseases.
Pancreatic &bgr;-Cell Function and Prognosis of Nondiabetic Patients With Ischemic Stroke

Background and Purpose— Pancreatic &bgr;-cell dysfunction is an important factor in the development of type 2 diabetes mellitus. This study aimed to estimate the association between &bgr;-cell dysfunction and prognosis of nondiabetic patients with ischemic stroke. Methods— Patients with ischemic stroke without a history of diabetes mellitus in the ACROSS-China (Abnormal Glucose Regulation in Patients with Acute Stroke across China) registry were included. Disposition index was estimated as computer-based model of homeostatic model assessment 2-&bgr;%/homeostatic model assessment 2-insulin resistance based on fasting C-peptide level. Outcomes included stroke recurrence, all-cause death, and dependency (modified Rankin Scale, 3–5) at 12 months after onset. Results— Among 1171 patients, 37.2% were women with a mean age of 62.4 years. At 12 months, 167 (14.8%) patients had recurrent stroke, 110 (9.4%) died, and 184 (16.0%) had a dependency. The first quartile of the disposition index was associated with an increased risk of stroke recurrence (adjusted hazard ratio, 3.57; 95% confidence interval, 2.13–5.99) and dependency (adjusted hazard ratio, 2.30; 95% confidence interval, 1.21–4.38); both the first and second quartiles of the disposition index were associated with an increased risk of death (adjusted hazard ratio, 5.09; 95% confidence interval, 2.51–10.33; adjusted hazard ratio, 2.42; 95% confidence interval, 1.17–5.03) compared with the fourth quartile. Using a multivariable regression model with restricted cubic spline, we observed an L-shaped association between the disposition index and the risk of each end point. Conclusions— In this large-scale registry, &bgr;-cell dysfunction was associated with an increased risk of 12-month poor prognosis in nondiabetic patients with ischemic stroke.
Thermal and hydrologic responses to climate change predict marked alterations in boreal stream invertebrate assemblages

Air temperature at the northernmost latitudes is predicted to increase steeply and precipitation to become more variable by the end of the 21st century, resulting in altered thermal and hydrological regimes. We applied five climate scenarios to predict the future (2070–2100) benthic macroinvertebrate assemblages at 239 near‐pristine sites across Finland (ca. 1200 km latitudinal span). We used a multitaxon distribution model with air temperature and modeled daily flow as predictors. As expected, projected air temperature increased the most in northernmost Finland. Predicted taxonomic richness also increased the most in northern Finland, congruent with the predicted northwards shift of many species’ distributions. Compositional changes were predicted to be high even without changes in richness, suggesting that species replacement may be the main mechanism causing climate‐induced changes in macroinvertebrate assemblages. Northern streams were predicted to lose much of the seasonality of their flow regimes, causing potentially marked changes in stream benthic assemblages. Sites with the highest loss of seasonality were predicted to support future assemblages that deviate most in compositional similarity from the present‐day assemblages. Macroinvertebrate assemblages were also predicted to change more in headwaters than in larger streams, as headwaters were particularly sensitive to changes in flow patterns. Our results emphasize the importance of focusing protection and mitigation on headwater streams with high‐flow seasonality because of their vulnerability to climate change.
Complete Plastid Genome Sequence of the Brown Alga Undaria pinnatifida

In this study, we fully sequenced the circular plastid genome of a brown alga, Undaria pinnatifida. The genome is 130,383 base pairs (bp) in size; it contains a large single-copy (LSC, 76,598 bp) and a small single-copy region (SSC, 42,977 bp), separated by two inverted repeats (IRa and IRb: 5,404 bp). The genome contains 139 protein-coding, 28 tRNA, and 6 rRNA genes; none of these genes contains introns. Organization and gene contents of the U. pinnatifida plastid genome were similar to those of Saccharina japonica. There is a co-linear relationship between the plastid genome of U. pinnatifida and that of three previously sequenced large brown algal species. Phylogenetic analyses of 43 taxa based on 23 plastid protein-coding genes grouped all plastids into a red or green lineage. In the large brown algae branch, U. pinnatifida and S. japonica formed a sister clade with much closer relationship to Ectocarpus siliculosus than to Fucus vesiculosus. For the first time, the start codon ATT was identified in the plastid genome of large brown algae, in the atpA gene of U. pinnatifida. In addition, we found a gene-length change induced by a 3-bp repetitive DNA in ycf35 and ilvB genes of the U. pinnatifida plastid genome.
Sleep Reduces the Testing Effect—But Not After Corrective Feedback and Prolonged Retention Interval

Retrieval practice relative to restudy of learned material typically attenuates time-dependent forgetting. A recent study examining this testing effect across 12-h delays filled with nocturnal sleep versus daytime wakefulness, however, showed that sleep directly following encoding benefited recall of restudied but not of retrieval practiced items, which reduced, and even eliminated, the testing effect after sleep (Bäuml, Holterman, & Abel, 2014). The present study investigated, in 4 experiments, whether this modulating role of sleep for the testing effect is influenced by two factors that have previously been shown to increase the testing effect: corrective feedback and prolonged retention intervals. Experiments 1a and 1b applied 12-h delays and showed benefits of sleep for recall after both restudy and retrieval practice with feedback, but not after retrieval practice without feedback. Experiments 2a and 2b applied 24-h or 7-day delays and failed to observe any long-lasting benefits of sleep directly after encoding, on both restudied and retrieval practiced items. These results indicate that both corrective feedback and prolonged retention intervals reduce the modulating role of sleep for the testing effect as it can be observed after 12-h delays and in the absence of corrective feedback, which suggests a fairly limited influence of sleep on the effect.
Numerical modelling and validation of precipitation kinetics in advanced creep resistant austenitic steel

The austenitic steel Sanicro 25 is one of the most promising austenitic steels for the application in superheater tubes in coal fired thermal power plants. In this work, the microstructural evolution of this material during heat treatment and thermal ageing has been investigated. The investigations were carried out by light microscopy (LIMI), scanning electron microscopy (SEM), transmission electron microscopy (TEM) and energy dispersive spectroscopy (EDS). Scheil calculations were carried out by thermo-kinetic software MatCalc to analyse the solidification process which indicates Nb(C,N), Cr2N and Laves phase in the melt. Long term precipitation calculations predict the formation of five precipitate types in Sanicro 25: M23C6, Z-phase, Nb(C,N), Laves and Cr2N. Phase fractions and mean radii evolution of precipitates were calculated and compared to the experimental results. Calculated precipitate evolution shows good compliance with experimental data.
Choosing to engage and choosing to persist: The role of non-specific factors in health-promoting activities.

OBJECTIVE Non-specific factors play an important role in determining benefits from health-promoting activities. Previous studies have focussed on beneficial outcomes of motivation during engagement. There are two aims of this project. First, we investigated whether expectancy and intrinsic motivation influence people's decisions to engage with health-promoting activities in the first instance and then subsequently adhere to them. Second, we examined the effects of providing information on health-promoting activities as a method of influencing expectancy and intrinsic motivation. METHOD In two studies, participants were informed about a health-promoting activity (Study 1: A breathing exercise for well-being; Study 2: A gratitude exercise for smoking cessation) and told that it has either a 'known' or 'unknown' effectiveness. Participants were then given the opportunity to engage with the activity over the following days. Expectancy and intrinsic motivation were measured after reading the information and prior to engagement with the activity. Adherence to the activity was measured at follow-up. RESULTS In both studies, intrinsic motivation positively predicted willingness to engage with the activities as well as subsequent adherence. Expectancy predicted adherence in Study 1 and choices to engage in Study 2, but not after controlling for intrinsic motivation. Describing the gratitude exercise as having a known effectiveness in Study 2 enhanced motivation and adherence to the activity. CONCLUSIONS The non-specific benefit brought by intrinsic motivation plays an important role in choosing to engage with health-promoting activities as well as subsequent adherence. Our results also show that simple statements about the potential benefits of a health-promoting activity can motivate engagement and adherence. Statement of contribution What is already known on this subject? Previous studies have established that non-specific factors, namely expectancies and intrinsic motivation, play an important role in determining benefit when engaging in health-promoting activities. These studies have neglected how non-specific factors relate to initial choices to engage in health-promoting activities in the first instance. Intrinsic motivation has been found to be more strongly related to benefit than expectancies in real-world health-promoting activities. What does this study add? Intrinsic motivation predicts choices to engage with a health-promoting activity. Simple statements about benefits of a health-promoting activity motivate engagement.
A Prospective International Multicentre Cohort Study of Intraoperative Heart Rate and Systolic Blood Pressure and Myocardial Injury After Noncardiac Surgery: Results of the VISION Study

BACKGROUND: The association between intraoperative cardiovascular changes and perioperative myocardial injury has chiefly focused on hypotension during noncardiac surgery. However, the relative influence of blood pressure and heart rate (HR) remains unclear. We investigated both individual and codependent relationships among intraoperative HR, systolic blood pressure (SBP), and myocardial injury after noncardiac surgery (MINS). METHODS: Secondary analysis of the Vascular Events in Noncardiac Surgery Cohort Evaluation (VISION) study, a prospective international cohort study of noncardiac surgical patients. Multivariable logistic regression analysis tested for associations between intraoperative HR and/or SBP and MINS, defined by an elevated serum troponin T adjudicated as due to an ischemic etiology, within 30 days after surgery. Predefined thresholds for intraoperative HR and SBP were: maximum HR >100 beats or minimum HR <55 beats per minute (bpm); maximum SBP >160 mm Hg or minimum SBP <100 mm Hg. Secondary outcomes were myocardial infarction and mortality within 30 days after surgery. RESULTS: After excluding missing data, 1197 of 15,109 patients (7.9%) sustained MINS, 454 of 16,031 (2.8%) sustained myocardial infarction, and 315 of 16,061 patients (2.0%) died within 30 days after surgery. Maximum intraoperative HR >100 bpm was associated with MINS (odds ratio [OR], 1.27 [1.07–1.50]; P < .01), myocardial infarction (OR, 1.34 [1.05–1.70]; P = .02), and mortality (OR, 2.65 [2.06–3.41]; P < .01). Minimum SBP <100 mm Hg was associated with MINS (OR, 1.21 [1.05–1.39]; P = .01) and mortality (OR, 1.81 [1.39–2.37]; P < .01), but not myocardial infarction (OR, 1.21 [0.98–1.49]; P = .07). Maximum SBP >160 mm Hg was associated with MINS (OR, 1.16 [1.01–1.34]; P = .04) and myocardial infarction (OR, 1.34 [1.09–1.64]; P = .01) but, paradoxically, reduced mortality (OR, 0.76 [0.58–0.99]; P = .04). Minimum HR <55 bpm was associated with reduced MINS (OR, 0.70 [0.59–0.82]; P < .01), myocardial infarction (OR, 0.75 [0.58–0.97]; P = .03), and mortality (OR, 0.58 [0.41–0.81]; P < .01). Minimum SBP <100 mm Hg with maximum HR >100 bpm was more strongly associated with MINS (OR, 1.42 [1.15–1.76]; P < .01) compared with minimum SBP <100 mm Hg alone (OR, 1.20 [1.03–1.40]; P = .02). CONCLUSIONS: Intraoperative tachycardia and hypotension are associated with MINS. Further interventional research targeting HR/blood pressure is needed to define the optimum strategy to reduce MINS.
Indenter geometrical effects on sub-micro/nano indentation and scratch behaviors of polymeric surfaces

Abstract In this work, we study the indenter geometrical effects on the nanoindentation and scratch behaviors of polymers (epoxy resin and its based nanocomposites) through both experimental and numerical approaches. Two different types of indenter commonly used in nanoindentation tests, Berkovich (i.e., three-sided pyramid-shaped) and conical-shaped, are studied. An indenter (tip) geometry reconstruction procedure is presented and the results are input into finite element models to better understand the mechanisms of the geometrical effects on nanoindentation. The effect of indenter geometry on nanoscratch behavior is also investigated experimentally. Overall, our results show that the corrected Oliver and Pharr's method is applicable to nanoindentation of polymeric surfaces and the indenter geometry plays significant roles in both the nanoindentation and nanoscratch tests. The conical-shaped indenter provides slightly overestimated mechanical parameters for the polymers tested due to the material pile-up. Therefore, for nanoindentation and scratch tests, the type of indenter should always be mentioned and comparisons between tests using different types of indenter should be taken with caution.
Discrepancy in Taiwanese psychiatrists’ preferences for long-acting injectable antipsychotics across facilities: a nationwide questionnaire survey

Background Although many studies have discussed psychiatrists’ attitudes toward long-acting injectable antipsychotics (LAIs), no previous study has focused on differences in preference based on the facilities in which the psychiatrists practiced. Materials and methods A pilot survey was conducted in a medical center in northern Taiwan, and a questionnaire was then distributed at the annual conference of the Taiwanese Society of Psychiatry in 2013. The questionnaire included general demographic data and preferences for the use of LAIs in different situations. Results A total of 142 psychiatrists were included in our study. Among them, 114 were male (80.3%), and most practiced in general hospitals (n=110, 77.5%). We found that general hospital psychiatrists were more likely to prescribe LAIs for patients in the acute stage and with positive symptoms than were psychiatric hospital psychiatrists. General hospital psychiatrists also tended to prescribe LAIs at every time point of the disease. Conclusion General hospital psychiatrists were more likely to prescribe LAIs than those in psychiatric hospitals. Knowing the factors affecting psychiatrists’ preferences may help us to develop a further study to explore “why” psychiatrists consider or do not consider LAIs in different facilities.
The adenomatous polyposis coli protein unambiguously localizes to microtubule plus ends and is involved in establishing parallel arrays of microtubule bundles in highly polarized epithelial cells

Loss of full-length adenomatous polyposis coli (APC) protein correlates with the development of colon cancers in familial and sporadic cases. In addition to its role in regulating β-catenin levels in the Wnt signaling pathway, the APC protein is implicated in regulating cytoskeletal organization. APC stabilizes microtubules in vivo and in vitro, and this may play a role in cell migration (Näthke, I.S., C.L. Adams, P. Polakis, J.H. Sellin, and W.J. Nelson. 1996. J. Cell Biol. 134:165–179; Mimori-Kiyosue, Y., N. Shiina, and S. Tsukita. 2000. J. Cell Biol. 148:505–517; Zumbrunn, J., K. Inoshita, A.A. Hyman, and I.S. Näthke. 2001. Curr. Biol. 11:44–49) and in the attachment of microtubules to kinetochores during mitosis (Fodde, R., J. Kuipers, C. Rosenberg, R. Smits, M. Kielman, C. Gaspar, J.H. van Es, C. Breukel, J. Wiegant, R.H. Giles, and H. Clevers. 2001. Nat. Cell Biol. 3:433–438; Kaplan, K.B., A. Burds, J.R. Swedlow, S.S. Bekir, P.K. Sorger, and I.S. Näthke. 2001. Nat. Cell Biol. 3:429–432). The localization of endogenous APC protein is complex: actin- and microtubule-dependent pools of APC have been identified in cultured cells (Näthke et al., 1996; Mimori-Kiyosue et al., 2000; Reinacher-Schick, A., and B.M. Gumbiner. 2001. J. Cell Biol. 152:491–502; Rosin-Arbesfeld, R., G. Ihrke, and M. Bienz. 2001. EMBO J. 20:5929–5939). However, the localization of APC in tissues has not been identified at high resolution. Here, we show that in fully polarized epithelial cells from the inner ear, endogenous APC protein associates with the plus ends of microtubules located at the basal plasma membrane. Consistent with a role for APC in supporting the cytoskeletal organization of epithelial cells in vivo, the number of microtubules is significantly reduced in apico-basal arrays of microtubule bundles isolated from mice heterozygous for APC.
STUDY OF SUPERPLASTIC FORMING PROCESS USING FINITE ELEMENT ANALYSIS

OF THESIS STUDY OF SUPERPLASTIC FORMING PROCESS USING FINITE ELEMENT ANALYSIS Superplastic forming (SPF) is a near net-shape forming process which offers many advantages over conventional forming operations including low forming pressure due to low flow stress, low die cost, greater design flexibility, and the ability to shape hard metals and form complex shapes. However, low production rate due to slow forming process and limited predictive capabilities due to lack of accurate constitutive models for superplastic deformation, are the main obstacles to the widespread use of SPF. Recent advancements in finite element tools have helped in the analysis of complex superplastic forming operations. These tools can be utilized successfully in order to develop optimized superplastic forming techniques. In this work, an optimum variable strain rate scheme developed using a combined micromacro stability criterion is integrated with ABAQUS for the optimization of superplastic forming process. Finite element simulations of superplastic forming of Ti-6Al-4V sheet into a hemisphere and a box are carried out using two different forming approaches. The first approach is based on a constant strain rate scheme. The second one is based on the optimum variable strain rate scheme. It is shown that the forming time can be significantly reduced without compromising the uniformity of thickness distribution when using the proposed optimum approach. Further analysis is carried out to study the effects of strain rate, microstructural evolution and friction on the formed product. Finally the constitutive equations and stability criterion mentioned above are used to analyze the forming of dental implant superstructure, a modern industrial application of superplastic forming.
The ethanolic extract of ashitaba stem (Angelica keskei [Miq.] Koidz) as future antituberculosis

Considering the easy contagion of tuberculosis (TB) disease spread and the emergence of multidrug-resistant TB, which directly impacts the failure of therapeutic goals and mortality rates increasing, TB disease control remains to be the main concern of continuous health development effort. Therefore, the discovery of new TB drug is needed. This research assessed the new natural anti-TB drug from the ethanolic extract of Angelica keiskei stem obtained from Lombok, Indonesia. The objectives of this study were to evaluate the sensitivity of Mycobacterium tuberculosis (Mtb) H37Rv strain to A. keiskei stem extract and to determine its minimum inhibitory concentration (MIC). The extraction methods of A. keiskei stem were done using a maceration method. In addition to phytochemical screening and water content analysis using standard method, the phytochemical parameters were analyzed by thin-layer chromatography. Ethanolic extract of A. keiskei stem was assayed for their Mtb inhibitory activity using the proportion method. The phytochemical analysis result showed that the secondary metabolites contain in the extract were flavonoid, polyphenol, tannin, monoterpenoid and sesquiterpen, quinon, and saponin. The anti-TB test result showed the active activity of ethanolic extract of A. keiskei against Mtb H37Rv strain with MIC ranging from 6% to 8% w/v. In conclusion, ethanolic extract of A. keiskei is a prospective natural anti-TB for the future.
Adjunctive metformin for antipsychotic-related hyperprolactinemia: A meta-analysis of randomized controlled trials

Hyperprolactinemia is a common and severe antipsychotic-induced adverse drug reaction. This meta-analysis of randomized controlled trials systematically examined the efficacy and safety of adjunctive metformin for antipsychotic-related hyperprolactinemia in schizophrenia patients. Two independent investigators searched, extracted, and synthesized data. Weighted mean differences and risk ratios with their 95% confidence intervals were calculated using random effect model. Four randomized controlled trials (n=509) comparing adjunctive metformin (n=253) with the control groups (n=256), lasting 22.7 weeks of treatment, were included in the meta-analysis. The metformin group had significantly lower serum prolactin level at endpoint (four randomized controlled trials, n=501; weighted mean difference: −6.87 ug/L (95% confidence interval: −13.24 to −0.51), p=0.03; I2=80%) with “moderate quality” based on the grading of recommendations assessment, development, and evaluation system. In patients with menstrual disturbances, the rate of menstruation resumption was 66.7% in the metformin group and 4.8% in the control group. Adverse drug reactions and all-cause discontinuation (three randomized controlled trials, n=339, risk ratio: 0.76 (95% confidence interval: 0.29, 1.97), p=0.57; I2= 0%) were similar between the two groups. Adjunctive metformin appears to be effective and safe for reducing antipsychotic-induced hyperprolactinemia and prolactin-related symptoms in schizophrenia patients. Higher quality randomized controlled trials with a large sample size are warranted to confirm these findings.