Miracle-dz/UniFAR-FTUs huggingface dataset:
Dissociation mediates the relationship between childhood trauma and hallucination-proneness

Background It has been proposed that the relationship between childhood trauma and hallucinations can be explained by dissociative processes. The present study examined whether the effect of childhood trauma on hallucination-proneness is mediated by dissociative tendencies. In addition, the influence of dissociative symptoms on a cognitive process believed to underlie hallucinatory experiences (i.e. reality discrimination; the capacity to discriminate between internal and external cognitive events) was also investigated. Method Patients with schizophrenia spectrum disorders (n=45) and healthy controls (with no history of hallucinations; n=20) completed questionnaire measures of hallucination-proneness, dissociative tendencies and childhood trauma, as well as performing an auditory signal detection task. Results Compared to both healthy and non-hallucinating clinical controls, hallucinating patients reported both significantly higher dissociative tendencies and childhood sexual abuse. Dissociation positively mediated the effect of childhood trauma on hallucination-proneness. This mediational role was particularly robust for sexual abuse over other types of trauma. Signal detection abnormalities were evident in hallucinating patients and patients with a history of hallucinations, but were not associated with pathological dissociative symptoms. Conclusions These results are consistent with dissociative accounts of the trauma-hallucinations link. Dissociation, however, does not affect reality discrimination. Future research should examine whether other cognitive processes associated with both dissociative states and hallucinations (e.g. deficits in cognitive inhibition) may explain the relationship between dissociation and hallucinatory experiences.
May I recruit through your agency? Considerations for researchers of spousal caregivers

ABSTRACT Few resources within social science literature provide helpful information related to participant recruitment for research on spousal caregivers of individuals with dementia. Independent researchers with limited resources may not have access to large databases or centers in which access to caregivers is readily available. As a result, these individuals may need to turn to local agencies, offices, or businesses that provide services or support to caregivers in order to recruit participants. However, gatekeepers whose interests include protecting this population often control such locations from third parties. Therefore, researchers may have to first contact these gatekeepers to attain permission to recruit participants. Using interviews and qualitative analysis, this study explored themes related to the attitudes and values that gatekeepers may have towards research and those who conduct it. This information can then be used by researchers to improve their approach to communicating with gatekeepers along with developing strong, professional relationships.
The Actin Associated Protein Palladin Is Important for the Early Smooth Muscle Cell Differentiation

Palladin, an actin associated protein, plays a significant role in regulating cell adhesion and cell motility. Palladin is important for development, as knockdown in mice is embryonic lethal, yet its role in the development of the vasculature is unknown. We have shown that palladin is essential for the expression of smooth muscle cells (SMC) marker genes and force development in response to agonist stimulation in palladin deficient SMCs. The goal of the study was to determine the molecular mechanisms underlying palladin's ability to regulate the expression of SMC marker genes. Results showed that palladin expression was rapidly induced in an A404 cell line upon retinoic acid (RA) induced differentiation. Suppression of palladin expression with siRNAs inhibited the expression of RA induced SMC differentiation genes, SM α-actin (SMA) and SM22, whereas over-expression of palladin induced SMC gene expression. Chromatin immunoprecipitation assays provided evidence that palladin bound to SMC genes, whereas co-immunoprecipitation assays also showed binding of palladin to myocardin related transcription factors (MRTFs). Endogenous palladin was imaged in the nucleus, increased with leptomycin treatment and the carboxyl-termini of palladin co-localized with MRTFs in the nucleus. Results support a model wherein palladin contributes to SMC differentiation through regulation of CArG-SRF-MRTF dependent transcription of SMC marker genes and as previously published, also through actin dynamics. Finally, in E11.5 palladin null mouse embryos, the expression of SMA and SM22 mRNA and protein is decreased in the vessel wall. Taken together, our findings suggest that palladin plays a key role in the differentiation of SMCs in the developing vasculature.
Cytokine Release in HR-HPV(+) Women without and with Cervical Dysplasia (CIN II and III) or Carcinoma, Compared with HR-HPV(−) Controls

Aims. We investigated the effect of HR-HPV infection on the capacity of the cytokine network in whole blood cultures during carcinogenesis of cervical carcinoma. Methods. Thirty-nine women with moderate dysplasia, severe dysplasia, cervical carcinoma, or without dysplasia formed the study group. The control group consisted of 10 HR-HPV-negative women without CIN. Whole blood cultures were stimulated with phytohemagglutinin (PHA) and concentrations of tumour necrosis factor α (TNFα), interferon γ (IFNγ), interleukin 2 (IL-2), interleukin 12 (IL-12), interleukin 4 (IL-4), and interleukin 10 (IL-10) were determined by ELISAs. Results. A significant increase in cytokine release was detected in HR-HPV-positive women without dysplasia. In women with cervical cancer, release of IFNγ and IL-12 was of the same magnitude as in HR-HPV-positive women without clinical manifestations. Most Th1-type/Th2-type ratios decreased form CIN II to CIN III, and increased from CIN III to invasive carcinoma. Conclusions. (1) Infection with HR-HPV without expression of cervical dysplasia induces activation of the cytokine network. (2) Increases in ratios of Th1-type to Th2-type cytokines at the stage of cervical carcinoma were found by comparison with stage CIN III. (3) Significant changes in the kinetics of cytokine release to a Th2-type immune response in blood of women with cervical dysplasia occurred progressively from CIN II to CIN III.
Invasive Potential Induced under Long-Term Oxidative Stress in Mammary Epithelial Cells

Although the causal relationship between chronic inflammation and carcinogenesis has long been discussed, the molecular basis of the relation is poorly understood. In the present study, we focused on reactive oxygen species (ROS) and their signals under inflammatory conditions leading to the carcinogenesis of epithelial cells and found that repeated treatment with a low dose of H2O2 (0.2 mmol/L) for periods of 2 to 4 days caused a phenotypic conversion of mouse NMuMG mammary epithelial cells from epithelial to fibroblast-like as in malignant transformation. The phenotypic conversion included the dissolution of cell-cell contacts, redistribution of E-cadherin in the cytoplasm, and up-regulation of a set of integrin family members (integrin α2, α6, and β3) and matrix metalloproteinases (MMPs; MMP-3, -10, and -13), as analyzed using Northern blot analysis and quantitative reverse transcription-PCR. Gelatin zymography indicated post-transcriptional activation of gelatinases, including MMP-2 and -9. In parallel, p38 mitogen-activated protein kinase and extracellular signal-regulated kinase 1/2 were activated, which contributed to the induction of MMP-13, and a glutathione S-transferase pull-down assay showed the activation of a small GTPase, Rac1. Surprisingly, the prolonged oxidative treatment was sufficient to induce all of the aforementioned events. Most importantly, depending on the MMP activities, the epithelial cells exposed to oxidative conditions eventually acquired invasiveness in a reconstituted model system with a Matrigel invasion chamber containing normal fibroblasts at the bottom, providing the first substantial evidence supporting the direct role of ROS signals in the malignant transformation of epithelial cells.
Analytical evaluation of switching characteristics in five-phase drives with discontinuous space vector pulse width modulation techniques

This paper deals with flux harmonic distortion factor (HDF) and current ripple analysis for various discontinuous space vector PWM (SVPWM) techniques, applicable in conjunction with five-phase two-level inverter-fed ac motor drives. The analysis is based on the application of the recently developed polygon approach for multiphase systems. The results are compared throughout with the corresponding continuous SVPWM techniques. Two different SVPWM methods, based on different selections of the active vectors, are encompassed by the analysis. The analytical study is supported with simulation and experimental result, obtained using a five-phase induction motor.
Linguistic priors shape categorical perception

ABSTRACT This article reviews recent literature on the role of top-down feedback processes in semantic representations in the brain. Empirical studies on perception and theoretical models of semantic cognition show that sensory input is filtered and interpreted based on predictions from higher order cognitive areas. Here, we review the present evidence to the proposal that linguistic constructs, in particular, words, could serve as effective priors, facilitating perception and integration of sensory information. We address a number of theoretical questions arising from this assumption. The focus here is if linguistic categories have a direct top-down effect on early stages of perception; or rather interact with later processing stages such as semantic analysis. We discuss experimental approaches that could discriminate between these possibilities. Taken together, this article provides a review on the interaction between language and perception from the predictive perspective, and suggests avenues to investigate the underlying mechanisms from this perspective.
Bacteremia as a Cause of Fever in Ambulatory, HIV-Infected Mozambican Adults: Results and Policy Implications from a Prospective Observational Study

Fever is typically treated empirically in rural Mozambique. We examined the distribution and antimicrobial susceptibility patterns of bacterial pathogens isolated from blood-culture specimens, and clinical characteristics of ambulatory HIV-infected febrile patients with and without bacteremia. This analysis was nested within a larger prospective observational study to evaluate the performance of new Mozambican guidelines for fever and anemia in HIV-infected adults (clinical trial registration NCT01681914, www.clinicaltrials.gov); the guidelines were designed to be used by non-physician clinicians who attended ambulatory HIV-infected patients in very resource-constrained peripheral health units. In 2012 (April-September), we recruited 258 HIV-infected adults with documented fever or history of recent fever in three sites within Zambézia Province, Mozambique. Although febrile patients were routinely tested for malaria, blood culture capacity was unavailable in Zambézia prior to study initiation. We confirmed bacteremia in 39 (15.1%) of 258 patients. The predominant organisms were non-typhoid Salmonella, nearly all resistant to multiple first-line antibiotics (ampicillin, chloramphenicol, and trimethoprim-sulfamethoxazole). Features most associated with bacteremia included higher temperature, lower CD4+ T-lymphocyte count, lower hemoglobin, and headache. Introduction of blood cultures allowed us to: 1) confirm bacteremia in a substantial proportion of patients; 2) tailor specific antimicrobial therapy for confirmed bacteremia based on known susceptibilities; 3) make informed choices of presumptive antibiotics for patients with suspected bacteremia; and 4) construct a preliminary clinical profile to help clinicians determine who would most likely benefit from presumptive bacteremia treatment. Our findings demonstrate that in resource-limited settings, there is urgent need to expand local microbiologic capacity to better identify and treat cases of bacteremia in HIV-infected and other patients, and to support surveillance. Data on the prevalence and susceptibility patterns of important pathogens can guide national formulary and prescribing practices.
Stratovolcano growth by co‐eruptive intrusion: The 2008 eruption of Tungurahua Ecuador

Volcanic edifices are constructed by a combination of erupted material and internal growth. We use the L‐band satellite ALOS to produce InSAR measurements at Tungurahua Volcano, Ecuador. We find a maximum of 17.5 cm of uplift on the upper western flank between December 2007 and March 2008, coincident with an eruption in February 2008. The deformation can be modeled using an ellipsoidal or sill‐like source within the edifice. The models require an elongated aspect ratio with a length of 4–6 km. The intruded volume of 1.2 × 106 m3 is roughly equivalent to the bulk erupted volume of 1.5 × 106 m3 and together the values are roughly equal to the long‐term magma flux. The question remains whether this uplift is permanent, thus contributing to the internal growth of the edifice, or temporary, in which case the magma will be released in a future eruption.
Early Aggressive Parenteral Nutrition Induced High Insulin-like growth factor 1 (IGF-1) and insulin-like growth factor binding protein 3 (IGFBP3) Levels Can Prevent Risk of Retinopathy of Prematurity

Objective To evaluate early aggressive vs. conservative nutrition and its effect on Retinopathy of Prematurity (ROP) in <32 weeks of gestation neonates. Methods A prospective, randomized, clinical study was conducted in NICU with a total of 75 preterm infants. In the intervention group, infants received early aggressive nutrition immediately after birth, in the control group infants were started on conventional parenteral nutrition (PN). Blood samples were obtained for Insulin-like growth factor 1 (IGF-1) and insulin-like growth factor binding protein 3 (IGFBP3) levels before commencement of PN on the first postnatal day, and from week 1 to 6 every week. All the infants were examined for ROP. Findings Infants in the early aggressive group had a reduction in the risk of ROP of 5% (2 from 40); the number of infants needed treatment averaged 3.7 (2.7 to 5.2). A total of 11 neonates in the conventional group were detected having ROP (P<0.05). Overall, IGF-I levels were higher in the aggressive PN (APN) vs the conventional PN (CPN). ROP development was higher in the CPN compared to the APN. IGF-1levels were lower in ROP developers compared with non-ROP in the APN group. There was no difference in IGF-I levels in ROP developers versus non-ROP in the CPN group. IGF-1 levels were lower in the CPN group compared with the APN group in the third week in ROP developers. There was a correlation between ROP and IGF-1 levels. Through ROC analysis, IGF-1 was demonstrated as being a sensitive marker for ROP. Conclusion IGF-1 levels were higher in the APN group versus the CPN group. This may indicate that IGF-1 levels simply being higher is not enough; rather, that being higher above a cutoff value may prevent ROP.
Following Digital Media into the Courtroom: Publicity and the Open Court Principle in the Information Age

Despite the pervasive integration of technology into various social institutions, one public body—the courtroom—has largely resisted such efforts. This separation is collapsing, however, as trial spectators increasingly arrive at court expecting to use their handheld digital devices inside to publish information about trials in real-time on live-blogging platforms. Consequently, Canadian courts have been forced to grapple with what role, if any, digital media is to play within their walls as this new information age puts pressure on a centuries old legal tradition. This article examines the debate on the use of digital devices in the courtroom from the perspective of the “open court principle,” as articulated in both law and general jurisprudential theory. It argues that using digital media as a platform to disseminate courtroom narratives has the potential to strengthen many of the open court principle’s foundational values, including accessibility, judicial accountability, and freedom of speech. These benefits may nonetheless come at a cost to the open court’s normative functions, since multiple, non-linear courtroom narratives created by digital media can undermine the publication of clear, determinate norms around which people can structure their lives. Accordingly, this article suggests that in deciding whether to permit digital media use in the courtroom, the justice system must determine which of the democratic values that underpin the open court principle ought to be given decisive weight in modern society.
Dual-Branch MRC Receivers Under Spatial Interference Correlation and Nakagami Fading

Despite being ubiquitous in practice, the performance of maximal-ratio combining (MRC) in the presence of interference is not well understood. Because the interference received at each antenna originates from the same set of interferers but partially decorrelates over the fading channel, it possesses a complex correlation structure. This paper develops a realistic analytic model that accurately accounts for the interference correlation using stochastic geometry. Modeling interference by a Poisson shot noise process with independent Nakagami fading, we derive the link success probability for dual-branch interference-aware MRC. Using this result, we show that the common assumption that all receive antennas experience equal interference power underestimates the true performance, although this gap rapidly decays with increasing the Nakagami parameter mI of the interfering links. In contrast, ignoring interference correlation leads to a highly optimistic performance estimate for MRC, especially for large mI. In the low outage probability regime, our success probability expression can be considerably simplified. Observations based from the analysis include the following: 1) For small path loss exponents, MRC and minimum mean square error combining exhibit similar performance, and 2) the gains of MRC over selection combining are smaller in the interference-limited case than in the well-studied noise-limited case.
Modulation of decision‐making in a gambling task in older adults with transcranial direct current stimulation

Cognitive performance usually declines in older adults as a result of neurodegenerative processes. One of the cognitive domains usually affected is decision‐making. Based on our recent findings suggesting that non‐invasive brain stimulation can improve decision‐making in young participants, we studied whether bifrontal transcranial direct current stimulation (tDCS) applied over the right and left prefrontal cortex of older adult subjects can change balance of risky and safe responses as it can in younger individuals. Twenty‐eight subjects (age range from 50 to 85 years) performed a gambling risk task while receiving either anodal tDCS over the right and cathodal tDCS over the left dorsolateral prefrontal cortex (DLPFC), anodal tDCS over the left with cathodal tDCS over the right DLPFC, or sham stimulation. Our main finding was a significant group effect showing that participants receiving left anodal/right cathodal stimulation chose more often high‐risk prospects as compared with participants receiving sham or those receiving right anodal/left cathodal stimulation. This result is contrary to previous findings in young subjects, suggesting that modulation of cortical activity in young and elderly results in opposite behavioral effects; thus supporting fundamental changes in cognitive processing in the elderly.
Aerosol physical and optical properties in the Eastern Mediterranean Basin, Crete, from Aerosol Robotic Network data

In this study, we investigate the aerosol optical properties, namely aerosol extinction optical thickness (AOT), Angstrom parameter and size distribution over the Eastern Mediterranean Basin, using spectral measurements from the recently established FORTH (Foundation for Research and Technology-Hellas) AERONET station in Crete, for the two-year period 2003–2004. The location of the FORTH-AERONET station offers a unique opportunity to monitor aerosols from different sources. Maximum values of AOT are found primarily in spring, which together with small values of the Angstrom parameter indicate dust transported from African deserts, whereas the minimum values of AOT occur in winter. In autumn, large AOT values observed at near-infrared wavelengths arise also from dust transport. In summer, large AOT values at ultraviolet (340 nm) and visible wavelengths (500 nm), together with large values of the Angstrom parameter, are associated with transport of fine aerosols of urban/industrial and biomass burning origin. The Angstrom parameter values vary on a daily basis within the range 0.05–2.20, and on a monthly basis within the range 0.68–1.9. This behaviour, together with broad frequency distributions and back-trajectory analyses, indicates a great variety of aerosol types over the study region including dust, urban-industrial and biomass-burning pollution, and maritime, as well as mixed aerosol types. Large temporal variability is observed in AOT, Angstrom parameter, aerosol content and size. The fine and coarse aerosol modes persist throughout the year, with the coarse mode dominant except in summer. The highest values of AOT are related primarily to southeasterly winds, associated with coarse aerosols, and to a less extent to northwesterly winds associated with fine aerosols. The results of this study show that the FORTH AERONET station in Crete is well suited for studying the transport and mixing of different types of aerosols from a variety of sources, especially those associated with major dust events from the Sahara.
Persona Effect Revisited --- Using Bio-signals to Measure and Reflect the Impact of Character-bas

The so-called 'persona effect' describes the phenomenon that a life-like interface agent can have a positive effect on the user's perception of a computer-based interaction task. Whereas previous empirical studies rely on questionnaires to evaluate the persona effect, we utilize bio-signals of users in order to precisely associate the occurrence of interface events with users' autonomic nervous system (ANS) activity. In this paper, we first report on the results of an experiment with an agent-guided mathematical game suggesting that an interface character with affective behavior may significantly decrease user stress. Then, we describe a character-based job interview scenario where a user's affective state derived from physiological data is projected back (or 'mirrored') to the user in real-time. Rather than measuring the effect of an interface agent, the focus here is on employing a character as a medium to reflect the user's emotional state, a concept with some potential for emotional intelligence training and the medical domain, especially e-Healthcare.