Miracle-dz/UniFAR-FTUs huggingface dataset:
Variance differences in asymmetry scores on bilateral versus unilateral tasks

Abstract Kim and Levine (1991a) report that the correlations between subjects' asymmetry scores on left- and right-hemisphere specialised tasks are more positive when stimuli are presented bilaterally than when they are presented unilaterally (asymmetry scores computed as R-L for both tasks). This larger positive correlation may reflect the greater sensitivity of bilateral presentation to individual differences in non-stimulus-specific perceptual asymmetry, referred to in this paper as “characteristic perceptual asymmetry. ” If this is the case, variance in subjects' asymmetry scores on bilaterally presented tasks should be greater than on unilaterally presented tasks, reflecting the contribution of individual differences in characteristic perceptual asymmetry as an additional source of variance. The findings reported in this paper are consistent with this hypothesis. That is, a re-analysis of relevant data reported in the literature shows that for both visual and auditory laterality tasks, variance in asy.
A Novel Affine Arithmetic Method to Solve Optimal Power Flow Problems With Uncertainties

An affine arithmetic (AA) method is proposed in this paper to solve the optimal power flow (OPF) problem with uncertain generation sources. In the AA-based OPF problem, all the state and control variables are treated in affine form, comprising a center value and the corresponding noise magnitudes, to represent forecast, model error, and other sources of uncertainty without the need to assume a probability density function (pdf). The proposed AA-based OPF problem is used to determine the operating margins of the thermal generators in systems with uncertain wind and solar generation dispatch. The AA-based approach is benchmarked against Monte Carlo simulation (MCS) intervals in order to determine its effectiveness. The proposed technique is tested and demonstrated on the IEEE 30-bus system and also a real 1211-bus European system.
Analysis of the prtP gene encoding porphypain, a cysteine proteinase of Porphyromonas gingivalis

The cloning and sequencing of the gene encoding porphypain, a cysteine proteinase previously isolated from detergent extracts of the Porphyromonas gingivalis W12 cell surface, are described. The prtP gene encoded a unique protein of 1,732 amino acids, including a putative signal sequence for protein secretion. The predicted molecular mass for the mature protein was 186 kDa, which was close to the observed molecular mass of 180 kDa. There was one copy of prtP in the genomes of seven P. gingivalis strains examined. The gene was located 5' to a region with a high degree of homology to the insertion element IS1126 in P. gingivalis W12. The PrtP protein had regions of high homology to HagA, a hemagglutinin of P. gingivalis, and to several purported proteinases of P. gingivalis that have Arg-X specificity. A detailed comparison of genes encoding the latter and cpgR suggested that rgp-1, prpR1, prtR, agp, cpgR, and possibly prtH were derived from identical genetic loci. Although an rgp-1-like locus was detected in seven P. gingivalis strains by Southern blot analyses, agp and cpgR were not detected, not even in the strains from which they were originally isolated. In addition, at least 20 copies of a repeat region common to PrtP, the Rgp-1-like proteins, and HagA were observed in each of the seven genomes examined. The repeat region hybridization patterns for strains W83 and W50 were very similar, and they were identical for strains 381 and ATCC 33277, providing further evidence that these strains are closely related genetically.
Biology of Aurora A kinase: Implications in cancer manifestation and therapy

The Aurora A kinase belongs to serine/threonine group of kinases, well known for its role in cell cycle, especially in the regulation of mitosis. Numerous substrates of Aurora A kinase have been identified, which are predominantly related to cell cycle progression while some of them are transcription factors. Aurora A‐mediated phosphorylation can either directly or indirectly regulate the function of its substrates. There are overwhelming evidences which report overexpression and gene amplification of Aurora A in several human cancers, and suggest that Aurora A could be a bona fide oncogene involved in tumorigenesis. Hence, Aurora A plays wide‐ranging roles in both mitosis and its deregulation manifests in cancer progression. These observations have favored the choice of Aurora kinases as a target for cancer therapy. Recently, numerous small molecules have been discovered against Aurora kinases and many have entered clinical trials. Most of these small‐molecule modulators designed are specific against either Aurora A or Aurora B, but some are dual inhibitors targeting the ATP‐binding site which is highly conserved among the three human homologues of Aurora kinase. In this review, we discuss the physiological functions of Aurora A, interactions between Aurora A kinase and its cellular substrates, tumorigenesis mediated by Aurora A kinase upon overexpression, and small‐molecule modulators of Aurora kinase as targets for cancer therapy. © 2010 Wiley Periodicals, Inc. Med Res Rev 31: 757‐793, 2011
Simultaneous Quantification of the 8 Human Herpesviruses in Allogeneic Hematopoietic Stem Cell Transplantation

Background Human herpesviruses may cause severe complications after allogeneic hematopoietic stem cell transplantation (HSCT). However, the impact of some of these infections on transplant outcomes is still unclear. A prospective survey on the incidence and clinical features of herpesviruses infections after HSCT has not yet been conducted in Brazilian patients, and the impact of these infections on HSCT outcome remains unclear. Methods We prospectively analyzed the incidence of infection of the eight human herpesviruses simultaneously in 1 045 peripheral blood samples from 98 allogeneic HSCT recipients. Samples were collected weekly starting at the time of transplant until day +100. All herpesviruses were screened and quantified in plasma by quantitative real-time polymerase chain reaction. Median follow up time was 24 months. Results The incidences of infection for each herpesvirus were as follows: cytomegalovirus (CMV), 44%; human herpesvirus [HHV] 6, 18%; HHV8, 6%; Epstein-Barr virus, 3%; herpes simplex virus 1, 3%; varicella zoster virus, 3%; HHV7, 2%; and herpes simplex virus 2, 1%. The CMV infection was significantly more frequent among adults and was associated with a higher risk of developing acute graft-versus-host disease. The HHV6 infection was significantly more frequent after umbilical cord blood transplant and was associated with an increased risk of platelet engraftment failure. There was no significant impact of these infections on the other transplant outcomes. Conclusions Herpesviruses infections were uncommon after HSCT, except for CMV and HHV6, which, although relatively frequent, had no clinically relevant impact on the outcomes.
CEO Portraits and the Authenticity Paradox

Top executive and CEO portraits represent significant sites for the visual construction of corporate identity and image, but they also highlight what we call the authenticity paradox. At first glance such photographs may appear to convey an impression of the kind of authentic presence many consider crucial for establishing a strong corporate image. But a closer look at the constructed nature of both CEO identity and portrait photography lays bare the elusive nature of authenticity itself, as well as the way that CEO portraits can function also to expose the corporation's chronic lack of authenticity. We explore the authenticity paradox and its implications by means of an analysis of executive portraits taken by one prominent Danish photographer, Per Morten Abrahamsen. We also map out an agenda for the further exploration of CEO portraits and images as an important element in the social and symbolic construction of business leadership.
Charcot Arthropathy of the Foot and Ankle Associated With Rheumatoid Arthritis

Background: Diabetic peripheral neuropathy is now well recognized as the most common cause of Charcot arthropathy of the foot and ankle, but it may be associated with other peripheral neuropathies. While not well known, it is well documented that rheumatoid arthritis is correlated with peripheral neuropathy. However, despite rheumatoid neuropathy, Charcot arthropathy has never been associated with rheumatoid arthritis. We report a series of Charcot arthropathy patients with concomitant rheumatoid arthritis. Methods: The medical records of patients treated between 1986 and 2009 with Charcot arthropathy and rheumatoid arthritis were reviewed. Recorded data included neuropathy risk factors, medications, history of ulcerations, ambulatory status, shoe wear, and treatment course. Radiographs of Charcot joints were categorized according to the Brodsky anatomic classification. Patient care was based on published treatment algorithms, emphasizing accommodative, nonoperative treatment with selective surgical interventions. Surgery was indicated for recalcitrant, nonhealing lesions of the soft tissue and/or unbraceable, nonplantigrade feet. A successful outcome was considered an ambulatory patient without amputation and a closed skin envelope at last follow-up. Results: Four men and 16 women met the diagnostic criteria, resulting in 33 feet in the series. Average age was 61 years, and average follow-up was 4.3 years. In addition to rheumatoid arthritis, 4 patients (7 feet) had hypothyroidism, 4 patients (6 feet) had diabetes, 1 patient (2 feet) had megaloblastic anemia and diabetes, and 1 patient (1 foot) had hypothyroidism and diabetes; however, 17 feet (52%) had no known sources for neuropathy. Charcot involvement was type 1–midfoot in 21 feet (64%), type 2–hindfoot in 7 (21%), type 3a–ankle in 4 (12%), and type 3b–calcaneus in 1 (3%). Twenty-three feet (70%) were treated with conservative modalities. Ten feet (30%) required 15 surgeries, of which an exostectomy was the most common procedure. Of the 33 feet, 3 had persistent ulcerations and 1 underwent major amputation, representing 4 failures. Conclusions: Raising awareness within the orthopaedic community, we report a Charcot arthropathy population with a concomitant rheumatoid arthritis diagnosis, emphasizing a relationship between the 2 diseases. Through a conservative treatment regimen combined with selective surgical interventions, satisfactory outcomes were achieved in 88% of the rheumatoid Charcot feet. While several patients had additional neuropathy sources which could cause Charcot arthropathy (eg, diabetes), the majority of feet had no etiologies accounting for neuropathy or neuroarthropathy except rheumatoid arthritis. Further study is required to expand on this relationship between the 2 diseases. Level of Evidence: Level IV, retrospective case series.
MiR-127 Modulates Macrophage Polarization and Promotes Lung Inflammation and Injury by Activating the JNK Pathway

A polarized macrophage response is presumed to have a pivotal role in a variety of immunological pathophysiology. However, the molecular mechanism underlying macrophage functional shaping remains largely unknown. In this study, we reveal a pivotal role of miR-127 in macrophage development and thereby the pathogenesis of inflammation and lung injury. In particular, miR-127 was demonstrated to be prominently induced upon TLR engagement and repressed by the M2-prone cytokines. Enforced expression of miR-127 in macrophages resulted in significantly increased production of proinflammatory cytokines, whereas deletion of miR-127 impaired M1 gene expression and led to a M2-biased response. Accordingly, intratracheal administration of miR-127 resulted in an exaggerated pulmonary inflammation and injury. Conversely, antagonizing of miR-127 suppressed production of the proinflammatory cytokines and rendered the mice more refractory to the inflammation-associated pathology. Mechanistically, miR-127 demonstrated to target B cell lymphoma 6 (Bcl6) and remarkably downregulated its expression and subsequently dual specificity phosphatase 1 (Dusp1), which in turn enhanced the activation of JNK kinase and hence the development of proinflammatory macrophages. Thereby, reconstitution with the expression of Bcl6 or Dusp1 or inhibition of JNK activity impaired miR-127–mediated skewing of M1 proinflammatory macrophages, whereas interference of Bcl6 or Dusp1 expression abrogated the anti-inflammatory property of anti–miR-127. Together, these data establish miR-127 as a molecular switch during macrophage development and as a potential target for treatment of inflammatory diseases.
Gaining Primacy in the Digital Network: Using Social Network Analysis to Examine Sports Journalists' Coverage of the Penn State Football Scandal via Twitter

This study explored the social network that developed amongst sports journalists as the Penn State football scandal evolved. The results suggest that Twitter is an essential domain for sports journalists to occupy when reporting sports stories. Further as sports journalists gain prominence in Twitter networks, they gain exposure to large audiences, thereby obtaining a prime agenda-setting position. Twitter has become a vital tool in sports journalists' repertoire and cannot be ignored.
Witnessing Parental Violence as a Traumatic Experience Shaping the Abusive Personality

Summary Previous work by Dutton and his colleagues has established a clinical profile on intimately abusive adult men that is quite similar to profiles of trauma victims in many essential clinical respects. Dutton (in press) showed that arousal modulation problems, affective monitoring, cognitive problem solving deficits, externalizing attributional styles, aggression and dissociative states are common to both groups. Furthermore, intimately abusive men demonstrate similar profiles as men diagnosed independently with PTSD on the MCMI-II. Dutton (1995a, 1995b) attributed the trauma to early assaults on the self through parental shaming, accompanied by insecure attachment and physical abuse victimization. Bowlby (1973) considered insecure attachment itself both a source and consequence of trauma. Since the infant turns to the attachment-object during periods of distress seeking soothing, a failure to obtain soothing maintains high arousal and endocrine secretion. Van der Kolk (1987) considered child abuse as an “overwhelming life experience” and reviewed the defenses that children use to deal with parental abuse: hypervigilance, projection, splitting, and denial. Terr (1979) also described driven, compulsive repetitions, and reenactments that permeate dreams, play, fantasies and object relations of traumatized children. Shaming, conceptualized as verbal or behavioral attacks on the global self, has been found to generate life-long shame-proneness or defenses involving rage. A combination of all three early experiences is traumatizing (Dutton, 1995a, 1995b; Dutton, in press). However, some evidence exists that suggests observation of interparental attacks can be substituted for physical abuse victimization as the third prong in this triad of traumatogenic experiences.
Effects of Two-Tier Multiple Choice Diagnostic Assessment Items on Students’ Learning Outcome in Basic Science Technology (BST)

This paper addresses the effect of The TTMC diagnostic assessment Model in basic science technology and to see if it can make an important contribution to the student learning outcome in basic science and technology among Nigerian students at the junior secondary school (JSS) level. The paper addresses the importance of the diagnostic assessment in basic science and technology and a review of development in particular the TTMC diagnostic instrument and sees if it can make any contribution to students’ learning outcome among Nigerian students at the Junior Secondary School (JSS) level. The study is a quasi-experimenter research designed to determine the effect of TTMC diagnostic instruction on students’ performance in BST. It is quasi experiment study in which the effect of the treatment on interest, attitude and achievement was measure as students’ learning outcome. The sample of the study consisted of 108 JSS basic science students selected randomly from 3 junior secondary schools in Ondo state Nigeria. Among these students were 54 male and 54 females selected through stratified random sampling technique. The instrument for dada collection in the study were BST Two-tiers multiple choice TTMC achievement test of 20 items adopted from Tan and Trannguest 1990; Tin 2004 Wang 2004; and from Chin and Ho 2002; The test was administered to the subject as pre- test; before the treatment and as post-test immediately after the treatment and the retention test after 4 weeks of the post-test except for the control group which was not expose to any treatment. The scores were analysed using mean; standard deviation; analysis of variance ANOVA; ANCOVA and the multiple classification analysis. DOI: 10.5901/ajis.2013. v2n2p201
Comparing the treatment effectiveness of body acupuncture and auricular acupuncture in preoperative anxiety treatment

BACKGROUND: Preoperative anxiety has become more frequent in preoperative patients and can bring negative impact on operation outcomes. Many studies have reported the effect of body acupuncture in reducing anxiety syndromes. The aim of this study is to compare the treatment effect of body acupuncture and auricular acupuncture in preoperative patients with preoperative anxiety. METHODS: Thirty five elective ambulatory surgery patients were selected in the randomized and blinded trial. Subjects were randomly categorized in two intervention groups, the body acupuncture group who received acupuncture in the special points of body, and the auricular acupuncture group who received ear acupuncture. Zung Self-Rating Anxiety Scale (SAS) was used before and after the study. RESULTS: For the auricular acupuncture group, the mean score of SAS was 57.57 ± 8.22 before the intervention and 46.32 ± 6.37 afterward. For the body acupuncture group, the SAS score was 55.39 ± 5.41 and 44.82 ± 6.76 before and after the intervention, respectively. For both groups, the difference between pre- and post-treatment scores reached the significant level (p = 0.00). CONCLUSIONS: Both auricular and body acupuncture treatment methods were effective in decreasing anxiety in preoperative patients.
Modular Porous Metal Augments for Treatment of Severe Acetabular Bone Loss during Revision Hip Arthroplasty

Modular acetabular augments were implanted in 16 patients (16 hips) for support of an uncemented hemispheric acetabular component during revision acetabular reconstruction. Based on the classification of Paprosky, acetabular bone defects were classified as 2A in one hip, 2B in three hips, 2C in one hip, 3A in five hips, and 3B in six hips. Preoperatively, the prosthetic femoral head centers were located at a mean horizontal distance of 18.6 mm (range, −3-46 mm), and a mean vertical distance of 27.6 mm (range, −16-52 mm) from the approximate femoral head center. Postoperatively, the prosthetic femoral head centers were located at a mean horizontal distance of 10.4 mm (range, 1-25 mm), and a mean vertical distance of 7.4 mm (range, −15-25 mm). At final followup, no implant had evidence of migration or loosening. At early clinical followup, this modular acetabular augment system seems helpful in acetabular reconstructions that cannot be treated with an uncemented hemispheric cup that would have required other forms of treatment such as structural allografts, acetabular cages, bilobed acetabular components, or custom acetabular components. Longer term followup is required to determine whether there are untoward effects of using a modular acetabular reconstructive system.
Coronary artery disease Pharmacotherapy for coronary microvascular dysfunction

Coronary microvascular dysfunction (CMD) has been increasingly recognized as an important cardiac condition that can cause signs and symptoms of myocardial ischaemia in various clinical settings. The dysfunction is located on the level of the coronary microcirculation with a vessel diameter of ,500 mm and can be characterized by structural as well as functional vascular alterations. The underlying mechanisms are diverse, frequently overlapping and still incompletely understood. A common and often underdiagnosed clinical manifestation of CMD is in patients who have angina symptoms yet no obstructive epicardial coronary artery disease nor myocardial disease. There are still very few data regarding the effectiveness of pharmacological treatments for CMD. The current ESC guidelines on the management of stable coronary artery disease suggest using aspirin and statins as well as b-blockers and/or calcium-channel blockers for the treatment of CMD. This review gives an overview of the currently available pharmacological concepts for the treatment of coronary microvascular dysfunction in patients without epicardial coronary artery disease and without myocardial disease.
Is ‘culture’ a justifiable variable for market segmentation? A cross‐cultural example

This paper investigates whether culture can be used to segment a market. Using Indians, resident in Britain (British Indians) as an example, previous research suggests that culture's manifestation within buyer behaviour provides sufficient evidence to justify its use as a market segment variable. Using brown goods (television sets, video equipment, music systems etc) a comparative quantitative study examined the impact of a range of cultural values upon the buying behaviour of British Indians and British Caucasians, to identify significant differences between the two. Although a significant difference was found, the amount of similarity between the two sample groups suggests culture should not be used as a segmentation variable. This research has implications for organisations seeking to develop ethnic minority orientated marketing strategies. Copyright © 2003 Henry Stewart Publications.
The Influence of Testosterone on Territorial Defence and Parental Behavior in Male Free-Living Rufous Whistlers, Pachycephala rufiventris


We studied a population of rufous whistlers, Pachycephala rufiventris, throughout a single breeding season in central New South Wales, Australia. We evaluated the relation between plasma testosterone (T) and reproductive behaviors using both simulated territorial intrusions (STIs) and subcutaneous T implants. We compared circulating T values to aggression levels of males (using STI) during pair bond and territory establishment and again during incubation. Although plasma T levels were significantly lower in the latter period, male responsiveness to STI, in terms of proximity to decoy, call rate, and number of attacks on the decoy, was indistinguishable between the two breeding stages. T levels of males exposed to STI were not different from the levels of unexposed free-living males at the same breeding stage. The effect of exogenous T on parental behavior was examined by comparing duration of incubation bouts of males and their mates prior to and after T treatment. T males significantly reduced the amount of time they incubated following implantation, whereas Control males maintained their incubation effort. After cessation of breeding activities, T males displayed significantly higher call rates due to increased use of the primary intersexual advertisement call in this species. The reduction of incubation behavior following T implantation emphasises the functional significance of the rapid decline in T in free-living males during incubation. The results from both experiments suggest that intersexual advertisement, rather than territorial aggression, may be dependent on high T levels in this species.