Miracle-dz/UniFAR-FTUs huggingface dataset:
Mutations in a β-tubulin disrupt spindle orientation and microtubule dynamics in the early C . elegans embryo

The early Caenorhabditis elegans embryo contains abundant transcripts for two α-and two β-tubulins raising the question of whether each isoform performs specialized functions or simply contributes to total tubulin levels. Our identification of two recessive, complementing alleles of a β-tubulin that disrupt nuclear-centrosome centration and rotation in the early embryo originally suggested that this tubulin, tbb-2, has specialized functions. However, embryos from tbb-2 deletion worms do not have defects in nuclear-centrosome centration and rotation suggesting that the complementing alleles are not null mutations. Both complementing alleles have distinct effects on microtubule dynamics and show allele-specific interactions with the two embryonically expressed α-tubulins: One of the alleles causes microtubules to be cold stable and resistant to the microtubule depolymerizing drug benomyl while the other causes cell-cycle specific defects in microtubule polymerization. Gene-specific RNAi targeting all four embryonically expressed tubulin genes singly and in all double combinations showed that the tubulin isoforms in the early embryo are largely functionally redundant with the exception of tbb-2. tbb-2 is required for centrosome stabilization during anaphase of the first cell division, suggesting that tbb-2 may be specialized for interactions with the cell cortex.
Modeling the performance of a photon counting x-ray detector for CT: energy response and pulse pileup effects.

PURPOSE Recently, photon counting x-ray detectors (PCXDs) with energy discrimination capabilities have been developed for potential use in clinical computed tomography (CT) scanners. These PCXDs have great potential to improve the quality of CT images due to the absence of electronic noise and weights applied to the counts and the additional spectral information. With high count rates encountered in clinical CT, however, coincident photons are recorded as one event with a higher or lower energy due to the finite speed of the PCXD. This phenomenon is called a "pulse pileup event" and results in both a loss of counts (called "deadtime losses") and distortion of the recorded energy spectrum. Even though the performance of PCXDs is being improved, it is essential to develop algorithmic methods based on accurate models of the properties of detectors to compensate for these effects. To date, only one PCXD (model DXMCT-1, DxRay, Inc., Northridge, CA) has been used for clinical CT studies. The aim of that study was to evaluate the agreement between data measured by DXMCT-1 and those predicted by analytical models for the energy response, the deadtime losses, and the distorted recorded spectrum caused by pulse pileup effects. METHODS An energy calibration was performed using 99mTc (140 keV), 57Co (122 keV), and an x-ray beam obtained with four x-ray tube voltages (35, 50, 65, and 80 kVp). The DXMCT-1 was placed 150 mm from the x-ray focal spot; the count rates and the spectra were recorded at various tube current values from 10 to 500 microA for a tube voltage of 80 kVp. Using these measurements, for each pulse height comparator we estimated three parameters describing the photon energy-pulse height curve, the detector deadtime tau, a coefficient k that relates the x-ray tube current I to an incident count rate a by a = k x I, and the incident spectrum. The mean pulse shape of all comparators was acquired in a separate study and was used in the model to estimate the distorted recorded spectrum. The agreement between data measured by the DXMCT-1 and those predicted by the models was quantified by the coefficient of variation (COV), i.e., the root mean square difference divided by the mean of the measurement. RESULTS Photon energy versus pulse height curves calculated with an analytical model and those measured using the DXMCT-1 were in agreement within 0.2% in terms of the COV. The COV between the output count rates measured and those predicted by analytical models was 2.5% for deadtime losses of up to 60%. The COVs between spectra measured and those predicted by the detector model were within 3.7%-7.2% with deadtime losses of 19%-46%. CONCLUSIONS It has been demonstrated that the performance of the DXMCT-1 agreed exceptionally well with the analytical models regarding the energy response, the count rate, and the recorded spectrum with pulse pileup effects. These models will be useful in developing methods to compensate for these effects in PCXD-based clinical CT systems.
Can Accurate Knowledge Reduce Wishful Thinking in Voters' Predictions of Election Outcomes?

Abstract About 3,000 Israeli voters were asked to predict the outcomes of the 1992 general election and to state their political preference. Political science students were found to possess more accurate knowledge than education students about some outcomes of the previous (1988) election, but the predictions made by both groups varied as a function of their preferences, indicating a wishful thinking effect. Wishful thinking effects of the same magnitude were found for groups differing in the accuracy of their knowledge about the outcomes of the previous election and for respondents who had been provided with partial or full base-rate information about the outcomes of the previous election. Thus, accurate knowledge did not reduce the effects of wishful preferences on predictions. Respondents' predictions differed from the results of public opinion polls published at the same time in the Israeli printed media. The results were more compatible with a motivational than with a purely cognitive interpretation.
Modelling spatial surface pellet distribution from rotary pneumatic feed spreaders

This paper presents a combined robotic and external ballistic model to predict the feed pellet distribution pattern across the water surface generated by a pneumatic rotary feed spreader commonly used in sea cage aquaculture. Results from experimental studies have been used to parameterize and validate the model. The model can be applied to evaluate spreader performance under varying operational conditions as well as exploring alternative spreader designs and configurations in order to optimize pellet distribution and feed utilization with respect to fish growth and welfare.
Characterizing common workplace communication skills for disorders associated with traumatic brain injury: A qualitative study.

BACKGROUND Interpersonal skill deficits are the primary reason for workplace separation after traumatic brain injury (TBI). Communication is integral to interpersonal skills, but workplace communication demands are inadequately described in the rehabilitation literature. OBJECTIVE This study describes inter-stakeholder examples of workplace communication behaviors for a level of employment to which people with TBI commonly attempt to return. METHODS Setting: Mid-level workplaces.Design: Semi-structured interviews were audio recorded, transcribed verbatim, then analyzed using thematic content analysis. Findings were linked to common communication deficits in persons with TBI.Participants: A volunteer sample of twenty healthy individuals employed in the mid-level workplaces, ten employees and ten supervisors.Main Outcome Measure(s): Taxonomy of communication skill deficits common in persons with TBI and associated with mid-level workplaces. RESULTS Interviews revealed seven communication-related skills associated with mid-level employment: 1) spoken language processing; 2) verbal memory; 3) reading and writing; 4) verbal reasoning; 5) expressive pragmatics; 6) multi-tasking; and 7) social cognition. CONCLUSION Workers and supervisors from an assortment of mid-level jobs with differing job contents all identified similarly common and important cross-occupational communication-related skills. Findings provide a preliminary guide to assess and treat communication skills for patients who have work re-entry as a goal.
Savoir refuser à l'écrit: analyse d'un enchaînement non préféré de macro-actes de discours

Abstract The aim of this article is to study rejection letters addressed to job applicants in France. Previous studies have predominantly dealt with the analysis of rejection in face-to-face interaction; but to date no empirical studies have focused on written refusals, especially in French. Moreover, although rejection letters represent bad news or dispreferred messages, researchers have devoted little attention to them in the light of Brown/Levinson's theory of politeness. To our knowledge, the only study on this subject is about characteristics of rejection letters and their impact on applicants' feelings about themselves, but Jablin and Krone (1984) adopt a psychological approach. The purpose of the present work is twofold. On the one hand, it is an attempt to provide both a description of the macro-structure of rejection letters and an inventory of the politeness strategies which appear in this discourse type. On the other hand, an attempt will be made to apply to our analysis of written discourse some tools which have been broadly applied in conversation analysis (preference organisation, adjacency pair, macro-speech act, etc.). Finally, it will be argued that in order to become more effective Brown/Levinson's theory must undergo a certain number of revisions: Face Threatening Acts (FTAs) should be analysed within a larger linguistic context in order to take into account quantitative aspects of politeness.
Health Benefits and Cost-Effectiveness of Primary Genetic Screening for Lynch Syndrome in the General Population

In current clinical practice, genetic testing to detect Lynch syndrome mutations ideally begins with diagnostic testing of an individual affected with cancer before offering predictive testing to at-risk relatives. An alternative strategy that warrants exploration involves screening unaffected individuals via demographic and family histories, and offering genetic testing to those individuals whose risks for carrying a mutation exceed a selected threshold. Whether this approach would improve health outcomes in a manner that is cost-effective relative to current standards of care has yet to be demonstrated. To do so, we developed a simulation framework that integrated models of colorectal and endometrial cancers with a 5-generation family history model to predict health and economic outcomes of 20 primary screening strategies (at a wide range of compliance levels) aimed at detecting individuals with mismatch repair gene mutations and their at-risk relatives. These strategies were characterized by (i) different screening ages for starting risk assessment and (ii) different risk thresholds above which to implement genetic testing. For each strategy, 100,000 simulated individuals, representative of the U.S. population, were followed from the age of 20, and the outcomes were compared with current practice. Findings indicated that risk assessment starting at ages 25, 30, or 35, followed by genetic testing of those with mutation risks exceeding 5%, reduced colorectal and endometrial cancer incidence in mutation carriers by approximately 12.4% and 8.8%, respectively. For a population of 100,000 individuals containing 392 mutation carriers, this strategy increased quality-adjusted life-years (QALY) by approximately 135 with an average cost-effectiveness ratio of $26,000 per QALY. The cost-effectiveness of screening for mismatch repair gene mutations is comparable to that of accepted cancer screening activities in the general population such as colorectal cancer screening, cervical cancer screening, and breast cancer screening. These results suggest that primary screening of individuals for mismatch repair gene mutations, starting with risk assessment between the ages of 25 and 35, followed by genetic testing of those whose risk exceeds 5%, is a strategy that could improve health outcomes in a cost-effective manner relative to current practice. Cancer Prev Res; 4(1): 9–22. ©2010 AACR. Cancer Prev Res; 4(1); 9–22. ©2010 AACR.
Sleep Patterns and Predictors of Poor Sleep Quality among Medical Students in King Khalid University, Saudi Arabia.

BACKGROUND Sleep problems and poor sleep quality are important issues for medical students. This study aimed to investigate the sleep patterns, measure the prevalence of poor sleep quality, and identify the predictors of poor sleep among medical students in King Khalid University (KKU), Saudi Arabia. METHODS This cross-sectional study enrolled 318 medical students during October-November, 2015. Participants were selected by convenience sampling and data were collected using self-administered questionnaires to obtain information regarding socio-demographic variables and indicators of sleep quality. RESULTS The overall mean sleep quality score was 6.79 with a standard deviation of 3.06. Poor sleep quality was reported by 74.2% students. Significantly high mean sleep quality scores (Pittsburgh Sleep Quality Index) were observed for students with very poor subjective sleep quality (mean = 10.50, SD = 2.58), least sleep efficiency (mean = 11.21, SD = 2.23), shorter sleep duration (mean = 7.83, SD = 2.88), sleep onset latency more than 30 minutes (mean = 7.82, SD = 2.53), sleeping after midnight (mean = 7.53, SD = 2.95), and use of sleep aiding medication (mean = 8.78, SD = 3.5). Significant differences were observed between good sleepers and poor sleepers regarding these sleep characteristics. Poor sleep was predicted by sleep behaviours such as going to sleep after midnight (AOR = 2.18, 95% CI: 1.20, 3.94) and sleep duration of less than seven hours (AOR = 7.49, 95% CI: 4.24, 13.22). CONCLUSION Medical students of KKU have poor sleep quality. Longer sleep latency, going to sleep after midnight, and shorter sleep duration are important problems in this group.
Perfectionism and Therapeutic Alliance: A Review of the Clinical Research

In this review, we synthesize findings regarding the relationship between perfectionism and therapeutic alliance, most of which come from analyses by Blatt and colleagues. Results suggest what follows. First, patients’ initial level of perfectionism negatively affects patients’ bond with therapists and perception of therapists’ Rogerian attributes (empathy, congruence, and regard) early in treatment and engagement in therapy later in treatment. Second, therapists’ contribution to alliance is not seemingly affected by patients’ initial perfectionism level. Third, individual patients of therapists who are perceived on average by their patients to be higher on Rogerian attributes experience greater decreases in perfectionism and symptoms. Fourth, more positive perceptions of therapists’ Rogerian attributes early in treatment lead to greater symptom decrease for patients with moderate perfectionism. Fifth, greater early patient engagement in therapy is related to greater decrease in perfectionism, but a strong relationship with the therapist may be necessary for an accompanied greater decrease in symptoms. The relationship between pre-treatment perfectionism and alliance is partially explained by higher levels of hostility and lower levels of positive affect. Sixth, the relationship between pre-treatment perfectionism and outcome is almost entirely explained by level of patient contribution to alliance and satisfaction with social network, highlighting the importance of focusing on social functioning for patients with high perfectionism (both in and outside of the session). Limitations include that most of the findings are from analyses of one large data set and a range of measurement issues. Future research should utilize different measures, perspectives, and populations and examine specific session process.
Individualizing Functional Assessments for Children with Autism

A functional assessment interview (O'Neill et al., 1997) was conducted with the care providers of 100 young (2 to 5 years old) children with autism regarding reinforcement contingencies contributing to maintenance of their child's disruptive behavior. Care providers were interviewed regarding their child's disruptive behavior related to gaining attention and tangibles and escaping demands. In addition, we individualized the interview in more detail to include the possible relationship between their child's disruptive behavior and gaining access to perseverative activities, avoiding demands when engaged in perseverative activities, and avoiding specific types of sensory stimulation. Results of the study suggest that gaining access to perseverative activities and escaping demands while engaged in these activities frequently contribute to disruptive behavior in young children with autism. These findings are discussed in terms of assessment considerations and treatment for children with autism and other types of syndromes and disorders.
Immunopathology of in situ seminoma

In this study of the seminomatous human testis the composition, activity and apoptosis of lymphocytes infiltrating the immune‐privileged seminiferous tubules with in situ seminoma were studied by immunohistochemistry and DNA fragmentation detection. Likewise the lymphocytes infiltrating the invasive seminomas were studied. The study showed equal numbers of CD4+ and CD8+ T cells and B cells, about 30% of the cells. Very few T γ/δ and NK cells were present. The activity in terms of IL‐2‐R, FasL and perforin expression was low. Apoptosis of the lymphocytic cells was limited. No differences were observed between the lymphocytes in seminiferous tubules with in situ seminoma and the lymphocytes in invasive tumours. The study suggests that either specifically committed lymphocytes are not present or, if present, immune‐suppressing mechanisms in addition to FasL may be working.
Prolactin secretion from human prolactinomas perifused in vitro: effect of TRH, prostaglandin E1, theophylline, dopamine and dopamine receptor blockers.

To clarify the functional characteristics of prolactin (Prl)-producing adenoma cells, the effect of TRH, prostaglandin E1 (PGE1), theophylline, dopamine and dopaminergic antagonists on Prl secretion was examined in vitro in perifused pituitary adenoma tissues obtained at surgery from 8 patients with prolactinoma. Perifusion with TRH at a concentration of 10(-6) to 10(-5) M resulted in a significant increase in effluent Prl levels in 3 of the 8 adenoma tissues. In the remaining 5 adenomas, TRH produced no effect on Prl release in vitro. On the other hand, PGE1 (10(-5) M) stimulated Prl secretion in 2 of the 4 adenomas examined. Addition of theophylline (5.5 mM) caused a marked increase of effluent Prl levels in all 8 prolactinomas regardless of the reactivity to TRH or PGE1. Dopamine (5 X 10(-7) M) suppressed Prl secretion from adenoma tissue in 5 of 7 patients tested but had no effect in the remaining two adenomas. When perifused simultaneously with dopamine, sulpiride (D2-selective dopamine receptor blocker, 5 X 10(-7) M) blocked the inhibitory effect of dopamine on Prl release in 3 of the 4 dopamine-sensitive prolactinomas. In one adenoma responsive to dopamine but resistant to sulpiride, YM-09151-2 (relatively specific D1-dopamine receptor blocker, 5 X 10(-7) M) antagonized the dopaminergic inhibition of Prl release. When perifused alone, neither sulpiride nor YM-09151-2 affected Prl release from any of the adenoma tissues tested. (ABSTRACT TRUNCATED AT 250 WORDS)
Occurrence of twin embryos in the eastern bluebird

We report the first record of presumed twinning in eastern bluebird (Sialia sialis) and provide a review of previously reported twinning events in wild birds. A nest containing twin eastern bluebird nestlings was monitored in 2013 in central Pennsylvania and reported to the Cornell Lab of Ornithology’s NestWatch program, a national program where volunteers submit data on wild nesting birds. A presumed double-yolked egg of a free-living eastern bluebird pair hatched successfully, and twin nestlings lived for 11 days in a nest box shared by three siblings. Due to the rarity of twinning in wild birds, engaging the public to monitor large numbers of nests is the most likely approach to documenting twinning in wild populations, and citizen science provides the infrastructure for individuals to share observations.
Changing Times: Findings From the First Longitudinal Study of Later High School Start Times

In the early 1990s, medical research found that teenagers have biologically different sleep and wake patterns than the preadolescent or adult population. On the basis of that information, in 1997 the seven comprehensive high schools in the Minneapolis Public School District shifted the school start timefrom 7:15 a. m. to 8:40 a. m. This article examines that change, finding significant benefits such as improved attendance and enrollment rates, less sleeping in class, and less student-reported depression. Policy implications are briefly discussed, acknowledging this to be a highly charged issue in school districts across the United States.
Locating Features in Source Code

Understanding the implementation of a certain feature of a system requires identification of the computational units of the system that contribute to this feature. In many cases, the mapping of features to the source code is poorly documented. In this paper, we present a semiautomatic technique that reconstructs the mapping for features that are triggered by the user and exhibit an observable behavior. The mapping is in general not injective; that is, a computational unit may contribute to several features. Our technique allows for the distinction between general and specific computational units with respect to a given set of features. For a set of features, it also identifies jointly and distinctly required computational units. The presented technique combines dynamic and static analyses to rapidly focus on the system's parts that relate to a specific set of features. Dynamic information is gathered based on a set of scenarios invoking the features. Rather than assuming a one-to-one correspondence between features and scenarios as in earlier work, we can now handle scenarios that invoke many features. Furthermore, we show how our method allows incremental exploration of features while preserving the "mental map" the analyst has gained through the analysis.
The Performance of School Assignment Mechanisms in Practice

We use a unique combination of register and survey data from Amsterdam to investigate the performance of school assignment mechanisms in practice. We find that deferred acceptance (DA) results in higher mean welfare than the adaptive Boston mechanism. This is due to students making strategic mistakes. The welfare gain of a switch from actual Boston to DA is over 90% of the welfare difference between actual Boston and optimal (proxy) Boston. Disadvantaged and lower-ability students would benefit most from such a switch.
Can peer code reviews be exploited for later information needs?

Code reviews have proven to be an effective means of improving overall software quality. During the review, there is an exchange of knowledge between the code author and reviewer that concerns the code being reviewed. We performed a study that looked at the code review practices of software product teams at Microsoft. The study results indicated that code reviews are a point at which design rationale is explicitly stated, but that retention and recovery of this information is not well supported in the current environment. The results also indicated that code reviews in collocated development environments such as Microsoft use a mix of face-to-face and electronic communication.