Miracle-dz/UniFAR-FTUs huggingface dataset:
Trypanosoma cruzi I genotype among isolates from patients with chronic Chagas disease followed at the Evandro Chagas National Institute of Infectious Diseases (FIOCRUZ, Brazil).

INTRODUCTION: Trypanosoma cruzi is the etiologic agent of Chagas disease in humans, mainly in Latin America. Trypanosome stocks were isolated by hemoculture from patients followed at Evandro Chagas National Institute of Infectious Diseases (FIOCRUZ) and studied using different approaches. METHODS: For species and genotype identification, the stocks were analyzed by parasitological techniques, polymerase chain reaction assays targeted to specific DNA sequences, isoenzyme patterns, besides sequencing of a polymorphic locus of TcSC5D gene (one stock). RESULTS: The isolates presented typical T. cruzi morphology and usually grew well in routine culture media. Metacyclic trypomastigotes were found in cultures or experimentally infected Triatoma infestans. All isolates were pure T. cruzi cultures, presenting typical 330-bp products from kinetoplast DNA minicircles, and 250 or 200-bp amplicons from the mini-exon non-transcribed spacer. Their genetic type assignment was resolved by their isoenzyme profiles. The finding of TcI in one asymptomatic patient from Paraíba was confirmed by the sequencing assay. TcVI was found in two asymptomatic individuals from Bahia and Rio Grande do Sul. TcII was identified in six patients from Pernambuco, Bahia and Minas Gerais, who presented different clinical forms: cardiac (2), digestive with megaesophagus (1), and indeterminate (3). CONCLUSIONS: The main T. cruzi genotypes found in Brazilian chronic patients were identified in this work, including TcI, which is less frequent and usually causes asymptomatic disease, unlike that in other American countries. This study emphasizes the importance of T. cruzi genotyping for possible correlations between the parasite and patient' responses to therapeutic treatment or disease clinical manifestations.
Heel effects on joint contact force components in the equine digit: a sensitivity analysis.

REASONS FOR PERFORMING STUDY Whereas the effect of heel configuration on the tension of the suspensory apparatus is well documented in the literature, there are few reports of joint contact force components in the equine distal forelimb. OBJECTIVES To improve understanding of the effect of heel configuration on equine digit joint loading, a sensitivity analysis was performed to compare the effect of a raised heel on joint contact force components in the coffin and fetlock joints during the stance phase of the trot. MATERIALS AND METHODS Four Warmblood horses were used. An inverse dynamic analysis was carried out using kinematic and kinetic data. Taking into account the tendon wrapping forces (WF) around the sesamoid bones in the calculations, the joint contact forces (CF) were estimated for the coffin and fetlock joints during the trot stance phase (4 m/s). To test the sensitivity of the results to heel configuration changes, calculations were performed repeatedly for different heel configurations (raised by 0, 6 and 12°). A one-way ANOVA with repeated measures was used to test the effect of heel configuration (at the 3 levels) (α = 0.05; P < 0.05; post hoc testing: Bonferroni). RESULTS For heel configurations raised from 0-12°: whereas the tension of the deep digital flexor tendon decreased and the tension of the superficial digital flexor tendon increased, for the coffin joint the peak WF (1.4 ± 0.25 bwt; 1.2 ± 0.2 bwt; 0.95 ± 0.1 bwt) and the peak CF (2.45 ± 0.25 bwt; 2.2 ± 0.2 bwt; 2 ± 0.1 bwt) decreased significantly (P < 0.05). For the fetlock joint, the peak WF (3.8 ± 0.7 bwt; 4.1 ± 0.3 bwt; 4.4 ± 0.25 bwt) and the peak CF (4.35 ± 0.7 bwt; 4.7 ± 0.35 bwt; 5 ± 0.3 bwt) increased, but not significantly. CONCLUSION This analysis suggests that the coffin joint loading and fetlock joint loading are strongly connected. The heel configuration may influence both coffin joint and fetlock joint contact force components.
An XMM-Newton study of the hard X-ray sky

We report on the spectral properties of a sample of 90 hard X-ray selected serendipitous sources detected in 12 XMM- Newton observations with 1 10 22 cm −2 )i s∼30%, with little evolution in the range 2 < F2−10 < 80 × 10 −14 erg cm −2 s −1 . Interestingly, this value is a factor ∼2 lower than predicted by the synthesis models of the CXB. This finding, detected for the first time in this survey, therefore suggests that most of the heavily obscured objects which make up the bulk of the CXB will be found at lower fluxes (F2−10 < 10 −14 erg cm −2 s −1 ). This mismatch together with other recent observational evidences which contrast with CXB model predictions suggest that one (or more) of the assumptions usually included in these models need to be revised.
Memory Processes Underlying Misinformation Effects in Child Witnesses.

Abstract In this article, we review empirical findings that misinformation effects in children are the joint product of automatic or unconscious and intentional or conscious processes. First, we outline the extant literature on multiple systems and process models of memory. Second, we examine how dual memory processes (e.g., recollection and automaticity, verbatim-based identity, and gist-based similarity) contribute to children's acceptance of misinformation. In this regard we outline findings that show developmental change in the cognitive processes underlying acceptance of misinformation in the absence of overall changes with age in the probability of reporting a suggestion. Competing models of the misinformation effect in children are then evaluated in light of this new evidence.
Accelerated Variance Reduced Block Coordinate Descent

Algorithms with fast convergence, small number of data access, and low per-iteration complexity are particularly favorable in the big data era, due to the demand for obtaining \emph{highly accurate solutions} to problems with \emph{a large number of samples} in \emph{ultra-high} dimensional space. Existing algorithms lack at least one of these qualities, and thus are inefficient in handling such big data challenge. In this paper, we propose a method enjoying all these merits with an accelerated convergence rate $O(\frac{1}{k^2})$. Empirical studies on large scale datasets with more than one million features are conducted to show the effectiveness of our methods in practice.
Identification and characterization of greater mood variance in depression

Objective: The authors sought to assess the quantity and quality of mood variation in depressed persons. Method: Using a visual analogue scale, they compared variation of mood in a group ofpatients (N=9) with a DSM-III-R diagnosis ofdepressive disorder and in a group of nondepressed subjects (N=9) over 12 consecutive hours. To quantify mood variation for each subject, the authors computed the standard deviation ofeach subject’s 13 mood ratings on the visualanalogue scale. To characterize the quality ofmood variation within each subject, they plotted each subject’s mood ratings as a function oftime and applied complex demodulation to confirm cyclical patterns of mood variability (ultradian cycles). Results: The depressed group demonstrated greater mood score variability over the course of the day. Both groups demonstrated ultradian cycles and circadian trends; however, the depressed group demonstrated ultradian cycles ofsignificantly greater amplitude than the nondepressed group. Conclusions: Repeated assessments ofmood at different times ofthe day may be necessary to obtain an accurate impression ofa patient’s mood state. Further, the mechanism of depressive disorders may include a deregulation ofa normal oscillatory mood variation pattern. (Am J Psychiatry1991;148:1341-1345)
Performance of hydroxyapatite bone repair scaffolds created via three-dimensional fabrication techniques.

The current study analyzes the in vivo performance of porous sintered hydroxyapatite (HA) bone repair scaffolds fabricated using the TheriForm solid freeform fabrication process. Porous HA scaffolds with engineered macroscopic channels had a significantly higher percentage of new bone area compared with porous HA scaffolds without channels in a rabbit calvarial defect model at an 8-week time point. An unexpected finding was the unusually large amount of new bone within the base material structure, which contained pores less than 20 microm in size. Compared with composite scaffolds of 80% polylactic-co-glycolic acid and 20% beta-tricalcium phosphate with the same macroscopic architecture as evaluated in a previous study, the porous HA scaffolds with channels had a significantly higher percentage of new bone area. Therefore, the current study indicates that scaffold geometry, as determined by the fabrication process, can enhance the ability of a ceramic material to accelerate healing of calvarial defects.
Understanding the Behavior of Simultaneous Multithreaded and Multiprocessor Architectures

Neither simulation results nor real system results give an explanation to the behavior of advanced computer systems for the full design spectrum. In this paper, we present simple models that explain the behavior of simultaneous multithreded, multiprocessor and multiprocessor with simultaneous multithreaded architectures. The results of these models show that there are limitations and problems with these architectures when using fast processors, and that the current single processor architecture will continue to be the target of system design for many years to come.
Facial Affect Recognition and Social Functioning in Individuals at Risk for Schizophrenia Spectrum Disorders

Facial Affect Recognition and Social Functioning in Individuals at Risk for Schizophrenia Spectrum Disorders by Marta Statucka Advisor: Deborah J. Walder, Ph.D. Facial affect recognition (FAR) is impaired in schizophrenia patients and to a lesser extent in individuals at familial/genetic, clinical, and psychometric risk for psychosis. Reduced FAR reaction time and negative bias are present in patients; however, their role is less clear in at-risk samples. Impaired social functioning, a hallmark of schizophrenia, is also impaired in at-risk individuals and is associated with FAR impairment. Given FAR deficits in schizophrenia, the current study aimed to elucidate the nature of FAR and social functioning impairments among individuals at high psychometric risk for psychosis and to examine whether FAR acts as a mediator in the relationship between schizotypal traits and social functioning. Nine-hundred and sixty-five (653 Female/312 Male) young adults were recruited from across CUNY campuses and asked to complete self-report measures assessing schizotypal traits (to determine psychometric risk status) and social functioning. Participants were also administered a computerized measure of FAR remotely via the Internet. Individuals at high psychometric risk performed significantly worse on total accuracy and neutral accuracy and were significantly more likely to misattribute negative emotions and sadness to neutral faces when compared to low-risk individuals. However, when adjusting for depressive symptoms, schizotypal traits were no longer associated with negative bias. Aspects of FAR performance were
Proteomic analysis identified N‐cadherin, clusterin, and HSP27 as mediators of SPARC (secreted protein, acidic and rich in cysteines) activity in melanoma cells

Secreted protein, acidic and rich in cysteines (SPARC) is a secreted protein associated with increased aggressiveness of different human cancer types. In order to identify downstream mediators of SPARC activity, we performed a 2‐DE proteomic analysis of human melanoma cells following antisense‐mediated downregulation of SPARC expression. We found 23/504 differential spots, 15 of which were identified by peptide fingerprinting analysis. Three of the differential proteins (N‐cadherin (N‐CAD), clusterin (CLU), and HSP27) were validated by immunoblotting, confirming decreased levels of N‐CAD and CLU and increased amounts of HSP27 in conditioned media of cells with diminished SPARC expression. Furthermore, transient knock down of SPARC expression in melanoma cells following adenoviral‐mediated transfer of antisense RNA confirmed these changes. We next developed two different RNAs against SPARC that were able to inhibit in vivo melanoma cell growth. Immunoblotting of the secreted fraction of RNAi‐transfected melanoma cells confirmed that downregulation of SPARC expression promoted decreased levels of N‐CAD and CLU and increased secretion of HSP27. Transient re‐expression of SPARC in SPARC‐downregulated cells reverted extracellular N‐CAD, CLU, and HSP27 to levels similar to those in the control. These results constitute the first evidence that SPARC, N‐CAD, CLU, and HSP27 converge in a unique molecular network in melanoma cells.
In vitro prevention by ACE inhibitors of cataract induced by glucose

Objectives: To study, the anticataract activity of lisinopril and enalapril on cataract induced by glucose, in goat lenses. Materials and Methods: Goat lenses were incubated in artificial aqueous humor containing 55 mM glucose (cataractogenesis) with lisinopril or enalapril in different concentrations at room temperature for 72 h. Biochemical parameters studied in the lens were electrolytes (Na+, K+), Na+-K+-ATPase activity, malondialdehyde (MDA) and proteins. Results: Glucose induced opacification of goat lens began 8-10 hrs after incubation and was complete in 72-80 hrs. Cataractous lenses showed higher Na+, MDA (P Conclusion: The anticataract activity of lisinopril and enalapril may be because of the antioxidant and free radical scavenging activity, as evidenced by a decrease in MDA in treated lenses. Further in-vitro and in-vivo studies in various experimental models and long term clinical trials are required to validate the anticataract activity of ACE-inhibitors.
Consistency of Chordal RCC-8 Networks

We consider chordal RCC-8 networks and show that we can check their consistency by enforcing partial path consistency with weak composition. We prove this by using the fact that RCC-8 networks with relations from the maximal tractable subsets H8, C8, and Q8 of RCC-8 have the patchwork property. The use of partial path consistency has important practical consequences that we demonstrate with the implementation of the new reasoner PyRCC∇, which is developed by extending the state of the art reasoner PyRCC8. Given an RCC-8 network with only tractable RCC-8 relations, we show that it can be solved very efficiently with PyRCC∇ by making its underlying constraint graph chordal and running path consistency on this sparse graph instead of the completion of the given network. In the same way, partial path consistency can be used as the consistency checking step in backtracking algorithms for networks with arbitrary RCC-8 relations resulting in very improved pruning for sparse networks while incurring a penalty for dense networks.
VisAge: augmented reality for heritage

In this paper we describe the VisAge project, which explored how a community-based Augmented Reality (AR) system could be used to tell stories and cultural histories about urban environments. Our work focussed on two main themes --- user engagement and immersiveness of the experience. To address the first theme, we developed an online portal where anybody could upload digital content and create their own stories using routes through a physical environment. To address the second theme, we developed a flexible, reconfigurable mobile platform to investigate different types and kinds of displays. The performance of the system was assessed in a series of workshops, which have provided insights to inform the development of future systems.
The secretin‐specific, chaperone‐like protein of the general secretory pathway: separation of proteolytic protection and piloting functions

The chaperone‐like protein of the main terminal branch of the general secretory pathway from Klebsiella oxytoca, the outer membrane lipoprotein PulS, protects the multimeric secretin PulD from degradation and promotes its correct localization to the outer membrane. To determine whether these are separable functions, or whether resistance to proteolysis results simply from correct localization of PulD, we replaced the lipoprotein‐type signal peptide of PulS by the signal peptide of periplasmic maltose‐binding protein. The resulting periplasmic PulS retained its ability to protect PulD, but not its ability to localize PulD to the outer membrane and to function in pullulanase secretion. Periplasmic PulS competed with wild‐type PulS to prevent pullulanase secretion, presumably again by causing mislocalization of PulD. A hybrid protein comprising the mature part of PulS fused to the C‐terminus of full‐length maltose‐binding protein (MalE–PulS) had similar properties to the periplasmic PulS protein. Moreover, MalE–PulS was shown to associate with PulD by amylose‐affinity chromatography. The MalE–PulS hybrid was rendered completely functional (i.e. it restored pullulanase secretion in a pulS mutant) by replacing its signal peptide with a lipoprotein‐type signal peptide. However, this fatty‐acylated hybrid protein was only functional if it also carried a lipoprotein sorting signal that targeted it to the outer membrane. Thus, the two functions of PulS are separate and fully dissociable. Incorrect localization, rather than proteolysis, of PulD in the absence of PulS was shown to be the factor that causes high‐level induction of the phage shock response. The Erwinia chrysanthemi PulS homologue, OutS, can substitute for PulS, and PulS can protect the secretin OutD from proteolysis in Escherichia coli, indicating the possible existence of a family of PulS‐like chaperone proteins.
INDIVIDUAL AND COMMUNITY FACTORS IN BULLYING AND VICTIMIZATION IN CANADA

ii Co-Authorship iii Acknowledgements iv Chapter 1 General Introduction 1 The Community Environment 3 Chapter 2 POWER DIFFERENTIALS IN BULLYING: INDIVIDUALS IN A COMMUNITY CONTEXT 7 Abstract 8 Introduction 9 Method 16 Results 23 Discussion 27 Chapter 3 MINORITY IN THE MAJORITY: COMMUNITY ETHNICITY AS A CONTEXT FOR RACIAL BULLYING AND VICTIMIZATION 41 Abstract 42 Introduction 43 Method 48 Results 55 Discussion 60 Chapter 4 General Discussion 76 References 82 Appendix A BULLYING AND VICTIMIZATION SCALES 103 Appendix B INDIVIDUAL SOCIODEMOGRAPHIC MEASURES 106 Appendix C SOCIAL INCLUSION MEASURES 109 Appendix D ETHICS CLEARANCE 111
An Experimental Investigation of Cognitive Response to Advertising: A Physiological Perspective for Tourism Destination Marketing

Abstract It is of considerable importance for tourism destination marketing organizations (DMOs) to understand the effects of various types of imagery-evoking stimuli on tourists’ visionary responses to advertising material. Accordingly, they face the need to evaluate the efficacy of advertising promotions. To date, however, there has been a paucity of research on the cognitive processes underlying the observed effects of ads featuring visuals and text versus audio mental imagery only within the context of the tourism field. This study explores how ads that include visuals and text compare with high imagery audio imagery in destination advertisements in affecting the allocation of processing resources to encode the message in memory. This study introduces a psychophysiology model—LC4MP—and a physiological measure (i.e., heart rate) that examines mental processing of tourism ads. The results indicate that high-imagery audio ads appear to lead people to invest more effort into committing the images to memory. Theoretical and practical implications are discussed.
‘Why don't you get somebody new to do it?’ Race and cultural taxation in the academy

Abstract There has been a marginal increase in the number of racial minorities among college and university faculty, yet current attacks on affirmative action and prevailing attitudes about the inferiority of non-white faculty place an extra burden on these individuals in academia. Amado Padilla (1994) introduced the concept of ‘cultural taxation’ to describe this burden where additional responsibilities are placed upon non-white faculty because of their ethno-racial backgrounds. These responsibilities include serving on numerous committees, advising larger numbers of students and serving as ‘departmental experts’ for their particular ethno-racial group. These expectations of non-white faculty are not placed as heavily upon white faculty, can impede career progress and affect job satisfaction. In this paper, we explore how cultural taxation affects faculty of colour in a research university. Additionally, we expand the analysis of cultural taxation to include issues of legitimacy that challenge non-white faculty's sense of ‘belonging’ within their respective departments.
Management Paradoxes: A Relational View

Paradox is gaining more and more pervasiveness in and around organizations, thus increasing the need for an approach to management that allows both researchers and practitioners to address these paradoxes. We attempt to contribute to this project by suggesting a relational approach to paradoxes. To this aim, we first present the state of the art of research on management paradoxes and then explain four regularities surfaced in the literature on this topic. We conclude by arguing that taking these regularities as a whole allows us to suggest a new perspective on paradoxes - one with a positive regard for the co-presence of opposites but that takes seriously the potential relationship between these.
Urban Geographies of Hesitant Transition: Tracing Socioeconomic Segregation in Post‐Ceauşescu Bucharest

Scholars have raised concerns about the social costs of the transition from state socialism to capitalism in Central and Eastern Europe, and geographers are particularly interested in the spatial expressions and implications of these costs, including apparently increasing residential segregation. Applying a range of segregation measures to 1992 and 2002 census data, this contribution studies socio-occupational residential segregation in Bucharest. The conclusion is that Bucharest was relatively socio-spatially mixed at both times; in fact, a modest, yet fully legible, decreasing overall trend is observable. This is at odds with many popular assumptions of the past 20 years.
The Effect of In‐Season, High‐Intensity Interval Training in Soccer Players

&NA; Dupont, G. , K. Akakpo, and S. Berthoin. The effect of in‐season, high‐intensity interval training in soccer players. J. Strength Cond. Res. 18(3):584–589. 2004. —The effects of inseason, high‐intensity interval training on professional male soccer players’ running performances were investigated. Twentytwo subjects participated in 2 consecutive training periods of 10 weeks. The first period was considered a control period and was compared with a period where 2 high‐intensity interval training exercises were included in the usual training program. Intermittent runs consisted of 12–15 runs lasting 15 seconds at 120% of maximal aerobic speed alternated with 15 seconds of rest. Sprint repetitions consisted of 12–15 all‐out 40‐m runs alternated with 30 seconds of rest. Results from the high‐intensity interval training have shown that maximal aerobic speed was improved (+ 8.1 ± 3.1%; p < 0.001) and that the time of the 40‐m sprint was decreased (‐3.5 ± 1.5%; p < 0.001), whereas no change in either parameters were observed during the control period. This study shows that improvements in physical qualities can be made during the in‐season period.
RyR2 Common Gene Variant G1886S and the Risk of Ventricular Arrhythmias in ICD Patients with Heart Failure

Cardiac ryanodine receptor 2 (RyR2) is critical to the electrical homeostasis of cardiomyocytes. Its gene variant rs3766871 entails channel destabilization and enhanced intracellular Ca2+ oscillation, thus promoting cardiac arrhythmias. We investigated whether the RyR2 rs3766871 variant is associated with aborted sudden cardiac death or ICD therapy for ventricular tachycardia (VT)/fibrillation (VF) in heart failure (HF) patients implanted with a cardioverter defibrillator (ICD).