Miracle-dz/UniFAR-FTUs huggingface dataset:
Using surface electromyography to assess sex differences in neuromuscular response characteristics.

OBJECTIVE To provide an overview of the continuum of muscular responses that typically occur with joint perturbation. The applications and limitations of surface electromyography (sEMG) in evaluating these responses are also addressed. Research applications assessing sex differences in these neuromuscular response characteristics are discussed along with suggestions for future research. DATA SOURCES MEDLINE was searched from 1969 through 1998. Sport DISCUS was searched from 1975 through 1998. Terms searched included "anterior cruciate ligament," "epidemiology," "neuromuscular control," "neuromuscular performance," "electromyography," "latency," "reflex," "electromechanical delay," "dynamic stability," "intrinsic stiffness," "short-range stiffness," "muscle," "mechanoreceptors," and "reaction time. " DATA SYNTHESIS It is widely accepted that efficient neuromuscular control is essential to dynamic joint stability and protection. Many studies have established the significant role of the muscles, and particularly the hamstrings, in providing knee stability. By observing the timing, phasing, and recruitment of reflexive muscular activation after a loading stress to the knee, we can better understand the coordinative mechanisms necessary to protect the joint and prevent ligament injury. A number of research models have employed the use of sEMG to evaluate neuromuscular responses at the knee after joint loading or perturbation. However, very few studies have specifically addressed potential sex differences in these response characteristics. CONCLUSIONS/RECOMMENDATIONS From the limited research available, it appears that a sex difference may exist in some aspects of neuromuscular responses. However, further research is needed to explore these differences at the knee and their potential role as predisposing factors to the higher incidence of anterior cruciate ligament injuries in females. Future studies should examine sex differences in neuromuscular response characteristics at the knee under functional, weight-bearing conditions while controlling for training and other confounding variables. The limitations of sEMG should be considered when interpreting neuromuscular response studies.
Chitotriosidase and soluble IL‐2 receptor: Comparison of two markers of sarcoidosis severity

Background. Sarcoidosis is a multisystemic granulomatous disease with an unpredictable clinical course characterized by accumulation of activated proliferating T lymphocytes and mononuclear phagocytes in affected organs. Aims and methods. The aims of this study were to describe the clinical, radiological and immunological features of a population of sarcoidosis patients followed at the Sarcoidosis Regional Centre in Siena and to analyse chitotriosidase and sIL‐2R concentrations in serum of these patients in order to understand their potential as disease markers. Results. Chitotriosidase and sIL‐2R concentrations in serum of sarcoidosis patients were found to be significantly higher than in healthy controls (p<0.01) and a positive correlation between the two markers was documented for the first time. Moreover, chitotriosidase and sIL‐2R were expressed differently in different radiographic stages of the disease. Conclusion. Chitotriosidase and sIL‐2R are two markers of sarcoidosis of different origin, the values of which show a correlation in these patients; they are easily detectable in serum and could be useful clinical markers of progression.
ScribbleSup: Scribble-Supervised Convolutional Networks for Semantic Segmentation

Large-scale data is of crucial importance for learning semantic segmentation models, but annotating per-pixel masks is a tedious and inefficient procedure. We note that for the topic of interactive image segmentation, scribbles are very widely used in academic research and commercial software, and are recognized as one of the most userfriendly ways of interacting. In this paper, we propose to use scribbles to annotate images, and develop an algorithm to train convolutional networks for semantic segmentation supervised by scribbles. Our algorithm is based on a graphical model that jointly propagates information from scribbles to unmarked pixels and learns network parameters. We present competitive object semantic segmentation results on the PASCAL VOC dataset by using scribbles as annotations. Scribbles are also favored for annotating stuff (e.g., water, sky, grass) that has no well-defined shape, and our method shows excellent results on the PASCALCONTEXT dataset thanks to extra inexpensive scribble annotations. Our scribble annotations on PASCAL VOC are available at http://research.microsoft. com/en-us/um/ people/jifdai/downloads/scribble_sup.
The V Gene Repertoires of Classical and Atypical Memory B Cells in Malaria-Susceptible West African Children

Immunity to Plasmodium falciparum malaria is naturally acquired in individuals living in malaria-endemic areas of Africa. Abs play a key role in mediating this immunity; however, the acquisition of the components of Ab immunity, long-lived plasma cells and memory B cells (MBCs), is remarkably inefficient, requiring years of malaria exposure. Although long-lived classical MBCs (CD19+/CD20+/CD21+/CD27+/CD10−) are gradually acquired in response to natural infection, exposure to P. falciparum also results in a large expansion of what we have termed atypical MBCs (CD19+/CD20+/CD21−/CD27−/CD10−). At present, the function of atypical MBCs in malaria is not known, nor are the factors that drive their differentiation. To gain insight into the relationship between classical and atypical IgG+ MBCs, we compared the Ab H and L chain V gene repertoires of children living in a malaria-endemic region in Mali. We found that these repertoires were remarkably similar by a variety of criteria, including V gene usage, rate of somatic hypermutation, and CDR-H3 length and composition. The similarity in these repertoires suggests that classical MBCs and atypical MBCs differentiate in response to similar Ag-dependent selective pressures in malaria-exposed children and that atypical MBCs do not express a unique V gene repertoire.
Cerebral blood flow velocity waveforms in hydrocephalic fetuses

Pulsed Doppler recordings of intracranial arterial velocity waveforms were made in 9 hydrocephalic fetuses during the second or third trimesters of pregnancy. Normal, increased, and decreased velocity waveform indices could be measured in these cases, and 1 fetus presented retrograde diastolic flow. Cerebral blood flow patterns of hydrocephalic fetuses seem to differ individually from case to case, presenting no uniform waveform type in late pregnancy. There was no obvious correlation between ventricular dilatation and the type of the velocity waveform.
Nocturnal non-invasive ventilation in addition to rehabilitation in hypercapnic patients with COPD

Background: Long-term non-invasive positive pressure ventilation (NIPPV) might improve the outcomes of pulmonary rehabilitation in patients with chronic obstructive pulmonary disease (COPD) with chronic respiratory failure. A study was undertaken to investigate whether nocturnal NIPPV in addition to pulmonary rehabilitation improves health-related quality of life, functional status and gas exchange compared with pulmonary rehabilitation alone in patients with COPD with chronic hypercapnic respiratory failure. Methods: 72 patients with COPD were randomly assigned to nocturnal NIPPV in addition to rehabilitation (n = 37) or rehabilitation alone (n = 35). Outcome measures were assessed before and after the 3-month intervention period. Results: The Chronic Respiratory Questionnaire total score improved 15.1 points with NIPPV + rehabilitation compared with 8.7 points with rehabilitation alone. The difference of 7.5 points was not significant (p = 0.08). However, compared with rehabilitation alone, the difference in the fatigue domain was greater with NIPPV + rehabilitation (mean difference 3.3 points, p<0.01), as was the improvement in the Maugeri Respiratory Failure questionnaire total score (mean difference −10%, p<0.03) and its cognition domain (mean difference −22%, p<0.01). Furthermore, the addition of NIPPV improved daytime arterial carbon dioxide pressure (mean difference −0.3 kPa; p<0.01) and daily step count (mean difference 1269 steps/day, p<0.01). This was accompanied by an increased daytime minute ventilation (mean difference 1.4 l; p<0.001). Conclusion: Non-invasive ventilation augments the benefits of pulmonary rehabilitation in patients with COPD with chronic hypercapnic respiratory failure as it improves several measures of health-related quality of life, functional status and gas exchange. Trial registration number: NCT00135538.
High-Throughput Quantitative Proteomic Analysis of Dengue Virus Type 2 Infected A549 Cells

Disease caused by dengue virus is a global health concern with up to 390 million individuals infected annually worldwide. There are no vaccines or antiviral compounds available to either prevent or treat dengue disease which may be fatal. To increase our understanding of the interaction of dengue virus with the host cell, we analyzed changes in the proteome of human A549 cells in response to dengue virus type 2 infection using stable isotope labelling in cell culture (SILAC) in combination with high-throughput mass spectrometry (MS). Mock and infected A549 cells were fractionated into nuclear and cytoplasmic extracts before analysis to identify proteins that redistribute between cellular compartments during infection and reduce the complexity of the analysis. We identified and quantified 3098 and 2115 proteins in the cytoplasmic and nuclear fractions respectively. Proteins that showed a significant alteration in amount during infection were examined using gene enrichment, pathway and network analysis tools. The analyses revealed that dengue virus infection modulated the amounts of proteins involved in the interferon and unfolded protein responses, lipid metabolism and the cell cycle. The SILAC-MS results were validated for a select number of proteins over a time course of infection by Western blotting and immunofluorescence microscopy. Our study demonstrates for the first time the power of SILAC-MS for identifying and quantifying novel changes in cellular protein amounts in response to dengue virus infection.
Path planning using probabilistic cell decomposition

We present a new approach to path planning in high-dimensional static configuration spaces. The concept of cell decomposition is combined with probabilistic sampling to obtain a method called probabilistic cell decomposition (PCD). The use of lazy evaluation techniques and supervised sampling in important areas leads to a very competitive path planning method. It is shown that PCD is probabilistic complete, PCD is easily scalable and applicable to many different kinds of problems. Experimental results show that PCD performs well under various conditions. Rigid body movements, maze like problems as well as path planning problems for chain-like robotic platforms have been solved successfully using the proposed algorithm.
Preadolescent conduct problems in girls and boys.

OBJECTIVE To examine sex differences in correlates of disruptive behavior disorders (DBDs) in preadolescent children using indicators of a wide range of well-established risk factors for DBDs and outcomes 3 years after initial assessment. METHOD Analyses were based on data for 5- to 10-year-olds (n = 5,913) from the British Child and Adolescent Mental Health Survey 1999, and a 3-year follow-up of selected subsamples (n = 1,440) at ages 8 through 13 years. DSM-IV diagnoses were assigned using the Developmental and Well-Being Assessment at both contacts. RESULTS Boys and girls were equally exposed to most social and family risks for DBDs, with little evidence of differential sensitivity to these risks. Boys were exposed more to neurodevelopmental difficulties, attention-deficit/hyperactivity disorder, and peer problems and had lower rates of prosocial behaviors; together, these factors and physical punishment could account for 54% of the observed sex differences in DBDs. At follow-up, outcomes for girls and boys with DBDs were very similar. For children with subthreshold conduct problems at initial assessment, boys were more likely to go on to exhibit DBDs than were girls (25% versus 7%). CONCLUSIONS Sex differences in the levels of a variety of child characteristics and interpersonal factors are likely to be important in understanding sex differences in risk for DBDs in preadolescent samples.
A Survey: Clustering Ensembles Techniques

The clustering ensembles combine multiple partitions generated by different clustering algorithms into a single clustering solution. Clustering ensembles have emerged as a prominent method for improving robustness, stability and accuracy of unsupervised classification solutions. So far, many contributions have been done to find consensus clustering. One of the major problems in clustering ensembles is the consensus function. In this paper, firstly, we introduce clustering ensembles, representation of multiple partitions, its challenges and present taxonomy of combination algorithms. Secondly, we describe consensus functions in clustering ensembles including Hypergraph partitioning, Voting approach, Mutual information, Co-association based functions and Finite mixture model, and next explain their advantages, disadvantages and computational complexity. Finally, we compare the characteristics of clustering ensembles algorithms such as computational complexity, robustness, simplicity and accuracy on different datasets in previous techniques.
The visual code navigator: an interactive toolset for source code investigation

We present the Visual Code Navigator, a set of three interrelated visual tools that we developed for exploring large source code software projects from three different perspectives, or views: the syntactic view shows the syntactic constructs in the source code. The symbol view shows the objects a file makes available after compilation, such as function signatures, variables, and namespaces. The evolution view looks at different versions in a project lifetime of a number of selected source files. The views share one code model, which combines hierarchical syntax based and line based information from multiple source files versions. We render this code model using a visual model that extends the pixel-filling, space partitioning properties of shaded cushion treemaps with novel techniques. We discuss how our views allow users to interactively answer complex questions on various code elements by simple mouse clicks. We validate the efficiency and effectiveness of our toolset by an informal user study on the source code of VTK, a large, industry-size C++ code base
Human 76p

The role of the centrosomes in microtubule nucleation remains largely unknown at the molecular level. γ-Tubulin and the two associated proteins h103p (hGCP2) and h104p (hGCP3) are essential. These proteins are also present in soluble complexes containing additional polypeptides. Partial sequencing of a 76- kD polypeptide band from these complexes allowed the isolation of a cDNA encoding for a new protein (h76p = hGCP4) expressed ubiquitously in mammalian tissues. Orthologues of h76p have been characterized in Drosophila and in the higher plant Medicago. Several pieces of evidence indicate that h76p is involved in microtubule nucleation. (1) h76p is localized at the centrosome as demonstrated by immunofluorescence. (2) h76p and γ-tubulin are associated in the γ-tubulin complexes. (3) γ-tubulin complexes containing h76p bind to microtubules. (4) h76p is recruited to the spindle poles and to Xenopus sperm basal bodies. (5) h76p is necessary for aster nucleation by sperm basal bodies and recombinant h76p partially replaces endogenous 76p in oocyte extracts. Surprisingly, h76p shares partial sequence identity with human centrosomal proteins h103p and h104p, suggesting a common protein core. Hence, human γ-tubulin appears associated with at least three evolutionary related centrosomal proteins, raising new questions about their functions at the molecular level.
Cryptic species of Didymobothrium rudolphii (Cestoda: Spathebothriidea) from the sand sole, Solea lascaris, off the Portuguese coast, with an analysis of their molecules, morphology, ultrastructure and phylogeny

SUMMARY Didymobothrium rudolphii (Cestoda: Spathebothriidea) was collected seasonally from the sand sole, Solea lascaris, off the northern, central and southern areas of the Portuguese coast. Morphological and molecular analyses were conducted in order to examine the possible existence of cryptic species and to facilitate the circumscription of their morphological boundaries. Data were compared between D. rudolphii specimens from each of the 3 geographical areas and 4 seasons, and principal components analysis of 18 morphological characters was used to detect differences. Two distinct genotypes were present with sequence divergences of 1·9% and 2·1% in the large subunit (lsrDNA) and second internal transcribed spacer (ITS-2) of ribosomal DNA (rDNA), respectively. The less common ‘central’ genotype was present only off the central area from summer to winter, whereas the ‘common’ genotype was present throughout the year off the northern and southern areas, but only during spring in the central area. No sequence variation was found within each genotype. The presence of 2 distinct genetic entities was supported by morphological analyses, which showed the ‘central’ genotype specimens to be more slender and elongate, although morphometric ranges overlapped considerably for most characters. Molecular phylogenetic analysis of 4 of the 5 known genera of the Spathebothriidea showed Spathebothrium to be the earliest branching lineage and the 2 genotypes of Didymobothrium formed a sister group to Cyathocephalus. The concordance of genetic differences with variation in host diet according to season and locality could account for sympatric speciation occurring in the central region of the Portuguese coast.
A correlative approach at characterizing nanoparticle mobility and interactions after cellular uptake

The interactions of nanoparticles with human cells are of large interest in the context of nanomaterial safety. Here, we use live cell imaging and image‐based fluorescence correlation methods to determine colocalization of 88 nm and 32 nm silica nanoparticles with endocytotic vesicles derived from the cytoplasmic membrane and lysosomes, as well as to quantify intracellular mobility of internalized particles, in contrast to particle number quantification by counting techniques. In our study, A549 cells are used as a model for human type II alveolar epithelial cells. We present data supporting endocytotic uptake of the particles and subsequent active transport to the perinuclear region. The presence of particles in lamellar bodies is proposed as a potential exocytosis route. (© 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Relationship between temperature rises with SAR in a head tissue in bandwidth exposure

In this paper we suppose to discuss recent results of study influence of Electromagnetic (EM) exposure of mobile phones radiation on the user. This is the part of topic: “Developing a Thermal Exemptions Rationale for Low-Power Transmitters”. Particularly, we present results of computer simulation of the users head exposure via radiation of electrically small and resonant length antennas. Compare and contrast threshold power with temperature increase in tissue and SAR. Investigate the relationship between temperature rise with SAR and between temperature rise and bandwidth/efficiency.
A robot-rat interaction experimental system based on the rat-inspired mobile robot WR-4

This research proposes to design and develop a novel robot involved in the general and famous animal experimental method called Social Interaction Test (SIT). Aiming at increased movement range of the waist and improved interoperability, we have developed a novel small animaroid robot WR-4 (Waseda Rat No.4). The waist of WR-4 endowed with a multi-bendable 6-bar linkage mechanism makes the robot able to rotate around ±130° horizontally, meeting required movement range. Integrating with a 4-bar linkage mechanism in the neck, this 6-bar linkage mechanism achieves the bending posture as living rats, allowing the imitation of behavior such as rotating. Furthermore, ultrasonic motors (USM) used to drive forelegs greatly reduce the weight of upper body, resulting in quicker acting of rearing behavior. WR-4 consists of 10 active DOFs (two 1-DOF wheels for locomotion, two 2-DOF forelegs for interaction, one 1-DOF neck for swing, one 2-DOF waist for rearing and body grooming and one 1-DOF reserved for tail) and 2 passive DOFs in the paws. The evaluation tests on motion performance show that WR-4 could act both rearing (reaching 60°) and rotating (reaching ±100° respectively) behaviors approximately 0.1s quicker than mature rats. Preliminary SIT between WR-4 and mature rats have been conducted strictly following psychological rules. Experimental results reveal that the frequencies of rearing behavior in rats were increased significantly when WR-4 reared periodically, and the activities of rats were decreased after WR-4 reared.
Counter-Conditioning as an Intervention to Modify Anti-Fat Attitudes

This study examined the effect of anti-fat attitude counter-conditioning using positive images of obese individuals participants completed implicit and explicit measures of attitudes towards fatness on three occasions: no intervention; following exposure to positive images of obese members of the general public; and to images of obese celebrities. Contrary to expectations, positive images of obese individuals did not result in more positive attitudes towards fatness as expected and, in some cases, indices of these attitudes worsened. Results suggest that attitudes towards obesity and fatness may be somewhat robust and resistant to change, possibly suggesting a central and not peripheral processing route for their formation.
Iterative Decoding Performance Bounds for LDPC Codes on Noisy Channels

The asymptotic iterative decoding performances of low-density parity-check (LDPC) codes using min-sum (MS) and sum-product (SP) decoding algorithms on memoryless binary-input output-symmetric (MBIOS) channels are analyzed in this paper. For MS decoding, the analysis is done by upper bounding the bit error probability of the root bit of a tree code by the sequence error probability of a subcode of the tree code assuming the transmission of the all-zero codeword. The result is a recursive upper bound on the bit error probability after each iteration. For SP decoding, we derive a recursively determined lower bound on the bit error probability after each iteration. This recursive lower bound recovers the density evolution equation of LDPC codes on the binary erasure channel (BEC) with inequalities satisfied with equalities. A significant implication of this result is that the performance of LDPC codes under SP decoding on the BEC is an upper bound of the performance on all MBIOS channels with the same uncoded bit error probability. All results hold for the more general multi-edge type LDPC codes.