Miracle-dz/UniFAR-FTUs huggingface dataset:
Brain Microbleeds and Global Cognitive Function in Adults Without Neurological Disorder

Background and Purpose— Increasing attention has been paid to associations between cognitive dysfunction and brain microbleeds (MBs). Because all previous studies have investigated patients with neurological disorders, we examined subjects without neurological disorder in order to clarify pathogenic relationships. Methods— A total of 518 consecutive adults without neurological disorder who had undergone health-screening tests of the brain were studied prospectively. Gradient-echo T2*-weighted MRI using a 1.5-T system was used to detect MBs. The Mini-Mental State Examination (MMSE) was administered to determine cognitive functions. MMSE scores <27 or >1.5 SDs below the age-related mean were regarded as subnormal. Results— MBs were found in 35 subjects (6.8%). MMSE score <27 was found in 25 subjects (4.8%), with MMSE score >1.5 SDs below the age-related mean in 34 subjects (6.6%). Univariate analysis showed presence and number of MBs, short duration of education, and severe white matter hyperintensities as significantly associated with subnormal scores. In logistic regression analysis, presence of MBs (odds ratio [OR], 5.44; 95% CI, 1.83 to 16.19) and number of MBs (OR, 1.32; 95% CI, 1.04 to 1.68) still displayed significant associations with MMSE score <27. Logistic regression analysis revealed a significant relationship between presence (OR, 3.93; 95% CI, 1.44 to 10.74) and number (OR, 1.26; 95% CI, 1.01 to 1.59) of MBs and MMSE score >1.5 SDs below the age-related mean. Among MMSE subscores, “attention and calculation” was significantly lower in MB-positive subjects (P=0.017). Conclusions— MBs appear to be primarily associated with global cognitive dysfunction.
Response of Tropical Terrestrial Gross Primary Production to the Super El Niño Event in 2015

The gross primary production (GPP) in tropical terrestrial ecosystems plays a critical role in the global carbon cycle and climate change. The strong 2015–2016 El Niño event offers a unique opportunity to investigate how GPP in the tropical terrestrial ecosystems responds to climatic forcing. This study uses two GPP products and concurrent climate data to investigate the GPP anomalies and their underlying causes. We find that both GPP products show an enhanced GPP in 2015 for the tropical terrestrial ecosystem as a whole relative to the multiyear mean of 2001–2015, and this enhancement is the net result of GPP increase in tropical forests and decrease in nonforests. We show that the increased GPP in tropical forests during the El Nino event is consistent with increased photosynthesis active radiation as a result of a reduction in clouds, while the decreased GPP in nonforests is consistent with increased water stress as a result of a reduction of precipitation and an increase of temperature. These results reveal the strong coupling of ecosystem and climate that is different in forest and nonforest ecosystems and provide a test case for carbon cycle parameterization and carbon‐climate feedback simulation in models.
Ocelli contribute to the encoding of celestial compass information in the Australian desert ant Melophorus bagoti

Many animal species, including some social hymenoptera, use the visual system for navigation. Although the insect compound eyes have been well studied, less is known about the second visual system in some insects, the ocelli. Here we demonstrate navigational functions of the ocelli in the visually guided Australian desert ant Melophorus bagoti. These ants are known to rely on both visual landmark learning and path integration. We conducted experiments to reveal the role of ocelli in the perception and use of celestial compass information and landmark guidance. Ants with directional information from their path integration system were tested with covered compound eyes and open ocelli on an unfamiliar test field where only celestial compass cues were available for homing. These full-vector ants, using only their ocelli for visual information, oriented significantly towards the fictive nest on the test field, indicating the use of celestial compass information that is presumably based on polarised skylight, the sun's position or the colour gradient of the sky. Ants without any directional information from their path-integration system (zero-vector) were tested, also with covered compound eyes and open ocelli, on a familiar training field where they have to use the surrounding panorama to home. These ants failed to orient significantly in the homeward direction. Together, our results demonstrated that M. bagoti could perceive and process celestial compass information for directional orientation with their ocelli. In contrast, the ocelli do not seem to contribute to terrestrial landmark-based navigation in M. bagoti.
The Origin of Carbonate Mud

Carbonate mudstones are key geochemical archives for past seawater chemistry, yet the origin of carbonate mud remains a subject of continued debate and uncertainty. Prevailing hypotheses have settled on two mechanisms: (1) direct precipitation in the water column and (2) postmortem dispersal of mud‐sized algal skeletal components. However, both mechanisms conflict with geochemical observations in modern systems and are problematic in deep time. We tested the hypothesis that abrasion of carbonate sand during sediment transport might produce carbonate mud using laboratory experiments and a sediment transport model. We documented experimental mud production rates up to two orders f magnitude faster than rates estimated for other mechanisms. Combined with model calculations, these results illustrated that transport and abrasion of carbonate sand is a major source of carbonate mud.
An Electrophysiological Investigation of the Effects of Social Rejection on Self Control

ABSTRACT Previous studies have shown that social rejection leads to impaired performance on a variety of tasks that require self control, including the Stroop color-word interference task; however, mechanisms underlying the effect remain to be elucidated. We attempted to clarify the effects of social rejection on self control resources by measuring event-related potentials (ERPs) during a computerized Stroop test. Stroop performance and ERPs from 54 participants in rejected, control, and accepted groups were analyzed. A significant difference in the pattern of results for the N450 ERP was found, with rejected participants showing less negativity on incongruent trials and more on congruent trials compared to accepted participants and controls. The results suggest social rejection reduces the engagement of cognitive control mechanisms, and are more consistent with a limited strength resource model than with limited capacity resource models that focus on limitations in attention.
Clinical Decision Rules for Pulmonary Embolism in Hospitalized Patients: A Systematic Literature Review and Meta-analysis

Abstract Background Clinical decision rules (CDRs) for pulmonary embolism (PE) have been validated in outpatients, but their performance in hospitalized patients is not well characterized. Objectives The goal of this systematic literature review was to assess the performance of CDRs for PE in hospitalized patients. Methods We performed a structured literature search using Medline, EMBASE and the Cochrane library for articles published on or before January 18, 2017. Two authors reviewed all titles, abstracts and full texts. We selected prospective studies of symptomatic hospitalized patients in which a CDR was used to estimate the likelihood of PE. The diagnosis of PE had to be confirmed using an accepted reference standard. Data on hospitalized patients were solicited from authors of studies in mixed populations of outpatients and hospitalized patients. Study characteristics, PE prevalence and CDR performance were extracted. The methodological quality of the studies was assessed using the QUADAS instrument. Results Twelve studies encompassing 3,942 hospitalized patients were included. Studies varied in methodology (randomized controlled trials and observational studies) and reference standards used. The pooled sensitivity of the modified Wells rule (cut-off ≤ 4) in hospitalized patients was 72.1% (95% confidence interval [CI], 63.7–79.2) and the pooled specificity was 62.2% (95% CI, 52.6–70.9). The modified Wells rule (cut-off ≤ 4) plus D-dimer testing had a pooled sensitivity 99.7% (95% CI, 96.7–100) and pooled specificity 10.8% (95% CI, 6.7–16.9). The efficiency (proportion of patients stratified into the ‘PE unlikely’ group) was 8.4% (95% CI, 4.1–16.5), and the failure rate (proportion of low likelihood patients who were diagnosed with PE during follow-up) was 0.1% (95% CI, 0–5.3). Conclusion In symptomatic hospitalized patients, use of the Wells rule plus D-dimer to rule out PE is safe, but allows very few patients to forgo imaging.
Sediment plume response to surface melting and supraglacial lake drainages on the Greenland ice sheet

Increased mass losses from the Greenland ice sheet and inferred contributions to sea-level rise have heightened the need for hydrologic observations of meltwater exiting the ice sheet. We explore whether temporal variations in ice-sheet surface hydrology can be linked to the development of a downstream sediment plume in Kangerlussuaq Fjord by comparing: (1) plume area and suspended sediment concentration from Moderate Resolution Imaging Spectroradiometer (MODIS) imagery and field data; (2) ice-sheet melt extent from Special Sensor Microwave/Imager (SSM/I) passive microwave data; and (3) supraglacial lake drainage events from MODIS. Results confirm that the origin of the sediment plume is meltwater release from the ice sheet. Interannual variations in plume area reflect interannual variations in surface melting. Plumes appear almost immediately with seasonal surface-melt onset, provided the estuary is free of landfast sea ice. A seasonal hysteresis between melt extent and plume area suggests late-season exhaustion in sediment supply. Analysis of plume sensitivity to supraglacial events is less conclusive, with 69% of melt pulses and 38% of lake drainage events triggering an increase in plume area. We conclude that remote sensing of sediment plume behavior offers a novel tool for detecting the presence, timing and interannual variability of meltwater release from the ice sheet.
In search of a function for the most frequent naturally-occurring length polymorphism (MFNLP) of the HIV-1 LTR: Retaining functional coupling, of Nef and RBF-2, at RBEIII?

Although the prototypical HIV-1 LTR sequences were determined 22 years ago from the initial isolate, elucidating which transcription factors are critical to replication in vivo, has been difficult. One approach has been to examine HIV-1 LTRs that have gone through the gamut of in vivo mutation and selection, in search of absolutely conserved sequences. In this vein, RBEIII sequences are virtually 100% conserved in naturally occurring HIV-1 LTRs. This is because when they are mutated, the MFNLP recreates an RBEIII site. Here, I enumerate some retroviral mutation mechanisms, which could generate the MFNLP. I then review the literature corresponding to the MFNLP, highlighting the discovery in 1999, that RBEIII and MFNLP sequences, bind USF and TFII-I cooperatively, within the context of earlier and later work that suggests a role in HIV-1 activation, through T-cell receptor engagement and the MAPK cascade. One exception to the nearly absolute conservation of RBEIII, has been a group of long term non progressors (LTNP). These patients harbor deletions to the Nef gene. However, the Nef gene overlaps with the LTR, and the LTNP deletions abrogate RBEIII, in the absence of an MFNLP. I suggest that the MFNLP retains functional coupling between the MAPK-mediated effects of Nef and the HIV-1 LTR, through RBEIII. I propose that difficult-to-revert-mutations, to either Nef or RBEIII, result in the convergent LTNP Nef/LTR deletions recently observed. The potential exploitation of this highly conserved protein-binding site, for chimeric transcription factor repression (CTFR) of HIV-1, functionally striving to emulate the LTNP deletions, is further discussed.
Comparing Ligand Interactions with Multiple Receptors via Serial Docking

Standard uses of ligand-receptor docking typically focus on the association of candidate ligands with a single targeted receptor, but actual applications increasingly require comparisons across multiple receptors. This study demonstrates that comparative docking to multiple receptors can help to select homology models for virtual compound screening and to discover ligands that bind to one set of receptors but not to another, potentially similar, set. A serial docking algorithm is furthermore described that reduces the computational costs of such calculations by testing compounds against a series of receptor structures and discarding a compound as soon as it fails to satisfy specified bind/no bind criteria for each receptor. The algorithm also realizes substantial efficiencies by taking advantage of the fact that a ligand typically binds in similar conformations to similar receptors. Thus, once detailed docking has been used to fit a ligand into the first of a series of similar receptors, much less extensive calculations can be used for the remaining structures.
Properties of nonlinear noise in long, dispersion-uncompensated fiber links

We study the properties of nonlinear interference noise (NLIN) in fiber-optic communications systems with large accumulated dispersion. Our focus is on settling the discrepancy between the results of the Gaussian noise (GN) model (according to which NLIN is additive Gaussian) and a recently published time-domain analysis, which attributes drastically different properties to the NLIN. Upon reviewing the two approaches we identify several unjustified assumptions that are key in the derivation of the GN model, and that are responsible for the discrepancy. We derive the true NLIN power and verify that the NLIN is not additive Gaussian, but rather it depends strongly on the data transmitted in the channel of interest. In addition we validate the time-domain model numerically and demonstrate the strong dependence of the NLIN on the interfering channels' modulation format.
The energetics of flow through a rapidly oscillating tube. Part 2. Application to an elliptical tube

In Part 1 of this work, we derived general asymptotic results for the three-dimensional flow field and energy fluxes for flow within a tube whose walls perform prescribed small-amplitude periodic oscillations of high frequency and large axial wavelength. In the current paper, we illustrate how these results can be applied to the case of flow through a finite-length axially non-uniform tube of elliptical cross-section – a model of flow in a Starling resistor. The results of numerical simulations for three model problems (an axially uniform tube under pressure–flux and pressure–pressure boundary conditions and an axially non-uniform tube with prescribed flux) with prescribed wall motion are compared with the theoretical predictions made in Part 1, each showing excellent agreement. When upstream and downstream pressures are prescribed, we show how the mean flux adjusts slowly under the action of Reynolds stresses using a multiple-scale analysis. We test the asymptotic expressions obtained for the mean energy transfer E from the flow to the wall over a period of the motion. In particular, the critical point at which E = 0 is predicted accurately: this point corresponds to energetically neutral oscillations, the condition which is relevant to the onset of global instability in the Starling resistor.
An Externally Forced Decadal Rainfall Seesaw Pattern Over the Sahel and Southeast Amazon

By analyzing observations and model simulations, here we show that there exists a significant anticorrelation on interannual to multidecadal time scales between the Sahel and southeast Amazon rainfall during July‐August‐September. This rainfall seesaw, which is strongest on decadal to multidecadal scales, is due to an anomalous meridional gradient of sea surface temperatures across the tropical Atlantic that pushes the Intertropical Convergence Zone and its associated rain belt toward the anomalously warm hemisphere. Large ensemble model simulations suggest that the seesaw pattern is likely caused by decadal changes in anthropogenic and volcanic aerosols, rather than internal climate variability. Our results suggest that the recent decadal to multidecadal climate variations in and around the North Atlantic basin are largely externally forced and that projected large North Atlantic warming could lead to a wetter Sahel but drier Amazon in the future.
Influence of Sunflower Whole Seeds or Oil on Ruminal Fermentation, Milk Production, Composition, and Fatty Acid Profile in Lactating Goats

This study aimed to investigate the effect of sunflower seeds, either as whole or as oil, on rumen fermentation, milk production, milk composition and fatty acids profile in dairy goats. Fifteen lactating Damascus goats were divided randomly into three groups (n = 5) fed a basal diet of concentrate feed mixture and fresh Trifolium alexandrinum at 50:50 on dry matter basis (Control) in addition to 50 g/head/d sunflower seeds whole (SS) or 20 mL/head/d sunflower seeds oil (SO) in a complete randomized design. Milk was sampled every two weeks during 90 days of experimental period for chemical analysis and rumen was sampled at 30, 60, and 90 days of the experiment for ruminal pH, volatile fatty acids (tVFA), and ammonia-N determination. Addition of SO decreased (p = 0.017) ruminal pH, whereas SO and SS increased tVFA (p<0.001) and acetate (p = 0.034) concentrations. Serum glucose increased (p = 0.013) in SO and SS goats vs Control. The SO and SS treated goats had improved milk yield (p = 0.007) and milk fat content (p = 0.002). Moreover, SO increased milk lactose content (p = 0.048) and feed efficiency (p = 0.046) compared to Control. Both of SS and SO increased (p<0.05) milk unsaturated fatty acids content specially conjugated linolenic acid (CLA) vs Control. Addition of SS and SO increased (p = 0. 021) C18:3N3 fatty acid compared to Control diet. Data suggested that addition of either SS or SO to lactating goats ration had beneficial effects on milk yield and milk composition with enhancing milk content of healthy fatty acids (CLA and omega 3), without detrimental effects on animal performance.
Who are you with and where are you going?

We propose an agent-based behavioral model of pedestrians to improve tracking performance in realistic scenarios. In this model, we view pedestrians as decision-making agents who consider a plethora of personal, social, and environmental factors to decide where to go next. We formulate prediction of pedestrian behavior as an energy minimization on this model. Two of our main contributions are simple, yet effective estimates of pedestrian destination and social relationships (groups). Our final contribution is to incorporate these hidden properties into an energy formulation that results in accurate behavioral prediction. We evaluate both our estimates of destination and grouping, as well as our accuracy at prediction and tracking against state of the art behavioral model and show improvements, especially in the challenging observational situation of infrequent appearance observations–something that might occur in thousands of webcams available on the Internet.
Do intuitive and deliberate judgments rely on two distinct neural systems? A case study in face processing

Arguably the most influential models of human decision-making today are based on the assumption that two separable systems – intuition and deliberation – underlie the judgments that people make. Our recent work is among the first to present neural evidence contrary to the predictions of these dual-systems accounts. We measured brain activations using functional magnetic resonance imaging while participants were specifically instructed to either intuitively or deliberately judge the authenticity of emotional facial expressions. Results from three different analyses revealed both common brain networks of activation across decision mode and differential activations as a function of strategy adherence. We take our results to contradict popular dual-systems accounts that propose a clear-cut dichotomy of the processing systems, and to support rather a unified model. According to this, intuitive and deliberate judgment processes rely on the same rules, though only the former are thought to be characterized by non-conscious processing.
Detergent-free domain isolated from Xenopus egg plasma membrane with properties similar to those of detergent-resistant membranes.

Microdomains known as "rafts" have been isolated from many cell types as detergent-resistant membranes (DRMs) and are enriched in sphingolipids and cholesterol. However, there has been considerable controversy over whether such domains are found in native membranes or are artificially generated by the purification procedure. This controversy is based at least in part on the fact that raft membranes were first detected following detergent extraction in the cold. We isolated two plasma membrane fractions, without detergent treatment, using a discontinuous sucrose density gradient. One fraction was designated "light" and the other "heavy. " These fractions were compared with DRMs, which were isolated in the presence of 1% Triton X-100. We found that Xenopus DRMs are enriched with sphingomyelin and cholesterol and exhibit a phase state similar to the liquid-ordered phase. Comparison of DRM complexes with the light and heavy plasma membrane fractions revealed some physical and biochemical similarities between the light fraction of the plasma membrane and the DRM complexes, based on (1) the phosphatidylcholine/sphingomyelin ratio and (2) the protein composition visualized on a two-dimensional gel. These two fractions are also quite similar in their thermotropic phase behavior, and their high levels of ganglioside GM1. We conclude that the light membrane fraction isolated in a detergent-free environment has many of the characteristics normally associated with DRMs.
Melatonin protects SH‐SY5Y neuroblastoma cells from calyculin A‐induced neurofilament impairment and neurotoxicity

Abstract: Hyperphosphorylation of cytoskeletal proteins seen in Alzheimer's disease is most probably the result of an imbalanced regulation in protein kinases and protein phosphatases (PP) in the affected neurons. Previous studies have revealed that PP‐2A and PP‐1 play important roles in the pathogenesis. Employing human neuroblastoma cells, we found that 10 nm calyculin A (CA), a selective inhibitor of PP‐2A and PP‐1, significantly increased phosphorylation and accumulation of neurofilament (NF) in the cells. Levels of NF‐M (middle chain) and NF‐L (light chain) mRNA decreased after CA treatment. Additionally, CA led to a decreased cell viability determined by MTT and crystal violet assay. Melatonin efficiently protects the cell from CA‐induced alterations in NF hyperphosphorylation and accumulation, suppressed NF gene expression as well as decreased cell viability. It is concluded that inhibition of PP‐2A/PP‐1 by CA induces abnormalities in NF metabolism and cell survival, and melatonin efficiently arrests the lesions.