Miracle-dz/UniFAR-FTUs huggingface dataset:
MODELING POROUS DUST GRAINS WITH BALLISTIC AGGREGATES. II. LIGHT SCATTERING PROPERTIES

We study the light scattering properties of random ballistic aggregates constructed in Shen et al. Using the discrete-dipole approximation, we compute the scattering phase function and linear polarization for random aggregates with various sizes and porosities, and with two different compositions: 100% silicate and 50% silicate +50% graphite. We investigate the dependence of light scattering properties on wavelength, cluster size, and porosity using these aggregate models. We find that while the shape of the phase function depends mainly on the size parameter of the aggregates, the linear polarization depends on both the size parameter and the porosity of the aggregates, with increasing degree of polarization as the porosity increases. Contrary to previous studies, we argue that the monomer size has negligible effects on the light scattering properties of ballistic aggregates, as long as the constituent monomer is smaller than the incident wavelength up to 2πa0/λ ∼ 1.6 where a0 is the monomer radius. Previous claims for such monomer size effects are in fact the combined effects of size parameter and porosity. Finally, we present aggregate models that can reproduce the phase function and polarization of scattered light from the AU Mic debris disk and from cometary dust, including the negative polarization observed for comets at scattering angles 160° ≲ θ < 180°. These aggregates have moderate porosities, , and are of sub-μm size for the debris disk case, or μm size for the comet case.
Simvastatin Induced Neurite Outgrowth Unveils Role of Cell Surface Cholesterol and Acetyl CoA Carboxylase in SH-SY5Y Cells

Statins are known to modulate cell surface cholesterol (CSC) and AMP-activated protein kinase (AMPK) in non-neural cells; however no study demonstrates whether CSC and AMPK may regulate simvastatin induced neuritogenesis (SIN). We found that simvastatin (SIM) maintains CSC as shown by Fillipin III staining, Flotillin-2 protein expression / localization and phosphorylation of various receptor tyrosine kinases (RTKs) in the plasma membrane. Modulation of CSC revealed that SIN is critically dependent on this CSC. Simultaneously, phospho array for mitogen activated protein kinases (MAPKs) revealed PI3K / Akt as intracellular pathway which modulates lipid pathway by inhibiting AMPK activation. Though, SIM led to a transient increase in AMPK phosphorylation followed by a sudden decline; the effect was independent of PI3K. Strikingly, AMPK phosphorylation was regulated by protein phosphatase 2A (PP2A) activity which was enhanced upon SIM treatment as evidenced by increase in threonine phosphorylation. Moreover, it was observed that addition of AMP analogue and PP2A inhibitor inhibited SIN. Bio-composition of neurites shows that lipids form a major part of neurites and AMPK is known to regulate lipid metabolism majorly through acetyl CoA carboxylase (ACC). AMPK activity is negative regulator of ACC activity and we found that phosphorylation of ACC started to decrease after 6 hrs which becomes more pronounced at 12 hrs. Addition of ACC inhibitor showed that SIN is dependent on ACC activity. Simultaneously, addition of Fatty acid synthase (FAS) inhibitor confirmed that endogenous lipid pathway is important for SIN. We further investigated SREBP-1 pathway activation which controls ACC and FAS at transcriptional level. However, SIM did not affect SREBP-1 processing and transcription of its target genes likes ACC1 and FAS. In conclusion, this study highlights a distinct role of CSC and ACC in SIN which might have implication in process of neuronal differentiation induced by other agents.
Regulation of Type IV Collagen α Chains of Glomerular Epithelial Cells in Diabetic Conditions

An early feature of diabetic nephropathy is the alteration of the glomerular basement membrane (GBM), which may result in microalbuminuria, subsequent macroproteinuria, and eventual chronic renal failure. Although type IV collagen is the main component of thickened GBM in diabetic nephropathy, cellular metabolism of each α chains of type IV collagen has not been well studied. To investigate the regulation of α(IV) chains in diabetic conditions, we examined whether glucose and advanced glycosylation endproduct (AGE) regulate the metabolism of each α(IV) chains in the diabetic tissue and glomerular epithelial cells (GEpC). Glomerular collagen α3(IV) and α5(IV) chains protein were higher and more intense in immunofluorescence staining according to diabetic durations compared to controls. In vitro, mainly high glucose and partly AGE usually increased total collagen protein of GEpC by [3H]-proline incorporation assay and each α(IV) chain proteins including α1(IV), α3(IV), and α5(IV) in time-dependent and subchain-specific manners. However, the changes of each α(IV) chains mRNA expression was not well correlated to the those of each chain proteins. The present findings suggest that the metabolism of individual α(IV) chains of GBM is differentially regulated in diabetic conditions and those changes might be induced not only by transcriptional level but also by post-translational modifications.
A Dynamic Theory of Common Law Courts

We develop a model that determines when and how time-consistent and forward-looking courts should set and reform legal rules (a normative theory for dynamically efficient courts). We explicitly take into account that: 1) the optimal rules most likely are not the same for all periods of time; 2) courts can only rule at trials; 3) the enforcement strategies of courts determine the litigation strategies of present and future parties in conflict; and 4) the parties in conflict can contract around the rules. As main results, we show that: 1) courts should set those rules that maximize the value of the present parties in conflict (statically efficient rules) only under extreme circumstances; 2) if legal rules are the only control variables, courts should adjust the unconstrained first-best rules for society in order to give the parties incentives to partially correct an inefficient frequency of litigation; 3) there always exists a distribution of the litigation expenses between the parties that generates an optimal frequency of trials in which case courts don't need to bias the rules. The model allows us to analyze the social desirability of two commonly suggested strategies to increase the frequency of shareholders' litigation: adding ambiguity to the law or involving public prosecutors as the N.Y. A.G. 's office or agencies as the S.E. C. In addition, the model also allows us to discuss when courts should set contingent rules (rules that adapt to the states of nature) instead of rigid rules (rules that don't adapt to the states of nature).
Fertilizer Response and Profitability in Rwanda: A Synthesis of Findings from MINAGRI Studies Conducted by The Food Security Research Project (FSRP) and The FAO Soil Fertility Initiative

The objectives of this paper are: to present in synthesis form key conclusions and recommendations of the FSRP/FAO-SFI studies on fertilizer profitability in Rwanda; and to incorporate information and comments obtained from participants in the December 15, 1999, MINAGRI Fertilizer Profitability Workshop conducted to present and validate the preliminary findings of the two studies.
Moral Hazard in Teams

This article studies moral hazard with many agents. The focus is on two features that are novel in a multiagent setting: free riding and competition. The free-rider problem implies a new role for the principal: administering incentive schemes that do not balance the budget. This new role is essential for controlling incentives and suggests that firms in which ownership and labor are partly separated will have an advantage over partnerships in which output is distributed among agents. A new characterization of informative (hence valuable) monitoring is derived and applied to analyze the value of relative performance evaluation. It is shown that competition among agents (due to relative evaluations) has merit solely as a device to extract information optimally. Competition per se is worthless. The role of aggregate measures in relative performance evaluation is also explored, and the implications for investment rules are discussed.
Protective Effect of Curcumin against the Liver Toxicity Caused by Propanil in Rats

We investigated the protective effects of curcumin on propanil-induced alterations in biochemical indices in blood and liver of male Wistar rats. The study consisted of four treatment groups, with six animals each, designated as control, propanil (20mg/kg), curcumin(50 mg/kg), and curcumin (50 mg/kg) + propanil (20 mg/kg). Rats were administered their respective doses orally, every other day, for 28 days. Propanil administration elicited significant (P < 0.001) increases in plasma aspartate aminotransferase and alkaline phosphatase activities, by 24% and 56%, respectively, compared to the control. Treatment with propanil elevated bilirubin, creatinine, and total cholesterol levels in rats, but these were not significant relative to controls. Administration of propanil to rats significantly (P < 0.001) increased lipid peroxidation levels. However, catalase activity, vitamin C, and reduced glutathione levels were significantly reduced. Exposure to propanil did not produce any significant changes in packed cell volume, neutrophils, and leukocyte counts. The supplementation of curcumin attenuated the adverse effects of propanil intoxication by reducing lipid peroxidation levels and restored the levels of serum enzymes and reduced glutathione. The present study showed that propanil increased oxidative stress and altered some biochemical parameters in the rats but curcumin could afford some protection to attenuate propanil-induced toxicity in the liver.
Attribute framing affects the perceived fairness of health care allocation principles

Health care resource allocation is a central moral issue in health policy, and opinions about it have been studied extensively. Allocation situations have typically been described and presented in a positive manner (i.e., who should receive medical aid). On the other hand, the negative valence allocation situation (i.e., who should not receive medical aid) has been relatively neglected. This paper demonstrates how positive versus negative framing of the exact same health care resource allocation situation can affect the perceived fairness of allocation principles. Participants usually perceived non-egalitarian principles (i.e., need, equity and tenure) to be fairer in positively framed situations (i.e., to deliver health care resources to certain patients) than negatively framed situation (i.e., not to deliver health care resources to other patients). However, framing did not affect the perceived fairness of the equality principle (i.e., a random draw). The paper offers a theoretical explanation for the effect of framing on the perceived fairness of health care resource allocation and discusses implications for both researchers and policy makers.
Highly Mutagenic Exocyclic DNA Adducts Are Substrates for the Human Nucleotide Incision Repair Pathway

Background Oxygen free radicals induce lipid peroxidation (LPO) that damages and breaks polyunsaturated fatty acids in cell membranes. LPO-derived aldehydes and hydroxyalkenals react with DNA leading to the formation of etheno(ε)-bases including 1,N 6-ethenoadenine (εA) and 3,N 4-ethenocytosine (εC). The εA and εC residues are highly mutagenic in mammalian cells and eliminated in the base excision repair (BER) pathway and/or by AlkB family proteins in the direct damage reversal process. BER initiated by DNA glycosylases is thought to be the major pathway for the removal of non-bulky endogenous base damage. Alternatively, in the nucleotide incision repair (NIR) pathway, the apurinic/apyrimidinic (AP) endonucleases can directly incise DNA duplex 5′ to a damaged base in a DNA glycosylase-independent manner. Methodology/Principal Findings Here we have characterized the substrate specificity of human major AP endonuclease 1, APE1, towards εA, εC, thymine glycol (Tg) and 7,8-dihydro-8-oxoguanine (8oxoG) residues when present in duplex DNA. APE1 cleaves oligonucleotide duplexes containing εA, εC and Tg, but not those containing 8oxoG. Activity depends strongly on sequence context. The apparent kinetic parameters of the reactions suggest that APE1 has a high affinity for DNA containing ε-bases but cleaves DNA duplexes at an extremely slow rate. Consistent with this observation, oligonucleotide duplexes containing an ε-base strongly inhibit AP site nicking activity of APE1 with IC50 values in the range of 5–10 nM. MALDI-TOF MS analysis of the reaction products demonstrated that APE1-catalyzed cleavage of εA•T and εC•G duplexes generates, as expected, DNA fragments containing 5′-terminal ε-base residue. Conclusions/Significance The fact that ε-bases and Tg in duplex DNA are recognized and cleaved by APE1 in vitro, suggests that NIR may act as a backup pathway to BER to remove a large variety of genotoxic base lesions in human cells.
The Major Surface-Associated Saccharides of Klebsiella pneumoniae Contribute to Host Cell Association

Analysing the pathogenic mechanisms of a bacterium requires an understanding of the composition of the bacterial cell surface. The bacterial surface provides the first barrier against innate immune mechanisms as well as mediating attachment to cells/surfaces to resist clearance. We utilised a series of Klebsiella pneumoniae mutants in which the two major polysaccharide layers, capsule and lipopolysaccharide (LPS), were absent or truncated, to investigate the ability of these layers to protect against innate immune mechanisms and to associate with eukaryotic cells. The capsule alone was found to be essential for resistance to complement mediated killing while both capsule and LPS were involved in cell-association, albeit through different mechanisms. The capsule impeded cell-association while the LPS saccharides increased cell-association in a non-specific manner. The electrohydrodynamic characteristics of the strains suggested the differing interaction of each bacterial strain with eukaryotic cells could be partly explained by the charge density displayed by the outermost polysaccharide layer. This highlights the importance of considering not only specific adhesin:ligand interactions commonly studied in adherence assays but also the initial non-specific interactions governed largely by the electrostatic interaction forces.
Dietary Supplementation of Benzoic Acid and Essential Oil Compounds Affects Buffering Capacity of the Feeds, Performance of Turkey Poults and Their Antioxidant Status, pH in the Digestive Tract, Intestinal Microbiota and Morphology

Three trials were conducted to evaluate the effect of supplementation of a basal diet with benzoic acid or thymol or a mixture of essential oil blends (MEO) or a combination of benzoic acid with MEO (BMEO) on growth performance of turkey poults. Control groups were fed a basal diet. In trial 1, benzoic acid was supplied at levels of 300 and 1,000 mg/kg. In trial 2, thymol or the MEO were supplied at levels of 30 mg/kg. In trial 3, the combination of benzoic acid with MEO was evaluated. Benzoic acid, MEO and BMEO improved performance, increased lactic acid bacteria populations and decreased coliform bacteria in the caeca. Thymol, MEO and BMEO improved antioxidant status of turkeys. Benzoic acid and BMEO reduced the buffering capacity compared to control feed and the pH values of the caecal content. Benzoic acid and EOs may be suggested as an effective alternative to AGP in turkeys.
Semi-static hedging for certain Margrabe-type options with barriers

It turns out that in the bivariate Black-Scholes economy Margrabe type options exhibit symmetry properties leading to semi-static hedges of rather general barrier options. Some of the results are extended to variants obtained by means of Brownian subordination. In order to increase the liquidity of the hedging instruments for certain currency options, the duality principle can be applied to set up hedges in a foreign market by using only European vanilla options sometimes along with a risk-less bond. Since the semi-static hedges in the Black-Scholes economy are exact, closed form valuation formulas for certain barrier options can be easily derived.
Low-current hollow cathode evaluation

An experimental investigation of the operating characteristics of 3.2 mm diameter orificed hollow cathodes was conducted to examine low-current and low flow rate operation. Cathode power was minimized with low orifice aspect ratio and the use of an enclosed keeper. Cathode flow rate requirements were proportional to orifice diameter and the inverse of the orifice length. Cathode temperature profiles were obtained using an imaging radiometer, and conduction was found to be the dominant heat transfer mechanism from the cathode tube. Orifice plate temperatures were found to be weakly dependent upon the flow rate and strongly dependent upon the current. Internal cathode pressures were measured to range from 39.2 to more than 66.5 kPa for spot mode emission. A model developed to describe the mass flow achieved good agreement with the experimental cathode pressures for heavy particle temperatures between 2900 and 6100 oC. Plasma properties measured within the insert region exclude the electron partial pressure from being responsible for the elevated cathode pressures. As such, it was concluded that the average heavy particle temperature in the orifice would have to be on the order of several thousand degrees C to account for the high internal pressure. Plasma parameters were also measured in the cathode-tokeeper gap and downstream of the keeper. The structure of the data enabled analysis of the current conduction processes in spot and plume modes. * Graduate Student Research Assistant, Student Member AIAA † Associate Professor, Associate Fellow AIAA ‡ Graduate Student Research Assistant, Student Member AIAA § Research Scientist, Member AIAA Copyright © 1999 by Matthew T. Domonkos. Published by the American Institute of Aeronautics and Astronautics with permission. Nomenclature A = normalization coefficient ARx = cathode with an orifice aspect ratio of x B r = magnetic field vector, G b = coefficient in EEDF exponent Do = orifice diameter, m E = electron energy, eV EEDF = electron energy distribution function f(E) = normalized EEDF Ipr = probe current, A J r = current density vector, A/m KL = coefficient of loss Lo = orifice length, m M = molar mass of Xe, 131 g/mol m& = mass flow rate, kg/s p = pressure, Pa pc = critical sonic pressure, Pa pin = insert region pressure, Pa po = orifice region pressure, Pa R = orifice radius, m R ~ = Ideal gas constant, 8.3145 J/mol-K u = mean flow velocity, m/s Vo = velocity at the orifice exit, m/s Vp = plasma potential, V Vpr = probe voltage, V x = axial distance, m, or exponent on electron energy in EEDF γ = ratio of specific heats, 5/3 μ = dynamic viscosity, N-s/m
Symbolic Processes in ERP versus Legacy System Support

Being hailed as possessing the ability to “drive effective business reengineering and management of core and support processes”, it is not surprising that Enterprise Resource Planning (ERP) systems have been adopted by more than 60% of Fortune 500 companies as at the turn of the century. In contrast, negative connotations have been commonly known to be attached to legacy systems and inhouse developed systems. But yet, some of these legacy systems are not replaced when companies adopt ERP solutions while in-house systems still continue to be developed. This research employs symbolic interactionism as the informing theoretical perspective in an ethnography study of a large government authority in Singapore. Our findings surprisingly indicate that the IS professionals supporting the systems tend to attach rather negative symbols to their SAP system, while viewing their legacy system and in-house software development work in a more favorable light. In this paper, we first describe the different symbolism that has been attached over the years to the ERP vis-a-vis legacy system. We then highlight how certain of the early symbols gradually got sedimented over time, while others did not exhibit similar permanence and presence. As a result of such symbolic realities, we demonstrate the consequent differences in attitudes of the staff involved in ERP support vis-a-vis legacy and in-house system support.
Does the Method of Weight Loss Effect Long-Term Changes in Weight, Body Composition or Chronic Disease Risk Factors in Overweight or Obese Adults? A Systematic Review

Background Differences in biological changes from weight loss by energy restriction and/or exercise may be associated with differences in long-term weight loss/regain. Objective To assess the effect of weight loss method on long-term changes in weight, body composition and chronic disease risk factors. Data Sources PubMed and Embase were searched (January 1990-October 2013) for studies with data on the effect of energy restriction, exercise (aerobic and resistance) on long-term weight loss. Twenty articles were included in this review. Study Eligibility Criteria Primary source, peer reviewed randomized trials published in English with an active weight loss period of >6 months, or active weight loss with a follow-up period of any duration, conducted in overweight or obese adults were included. Study Appraisal and Synthesis Methods Considerable heterogeneity across trials existed for important study parameters, therefore a meta-analysis was considered inappropriate. Results were synthesized and grouped by comparisons (e.g. diet vs. aerobic exercise, diet vs. diet + aerobic exercise etc.) and study design (long-term or weight loss/follow-up). Results Forty percent of trials reported significantly greater long-term weight loss with diet compared with aerobic exercise, while results for differences in weight regain were inconclusive. Diet+aerobic exercise resulted in significantly greater weight loss than diet alone in 50% of trials. However, weight regain (∼55% of loss) was similar in diet and diet+aerobic exercise groups. Fat-free mass tended to be preserved when interventions included exercise.
The Tracy–Widom limit for the largest eigenvalues of singular complex Wishart matrices

This paper extends the work of El Karoui [Ann. Probab. 35 (2007) 663--714] which finds the Tracy--Widom limit for the largest eigenvalue of a nonsingular $p$-dimensional complex Wishart matrix $W_{\mathbb{C}}(\Omega_p,n)$ to the case of several of the largest eigenvalues of the possibly singular $(n<p)$ matrix $W_{\mathbb{C}}(\Omega_p,n). $ As a byproduct, we extend all results of Baik, Ben Arous and Peche [Ann. Probab. 33 (2005) 1643--1697] to the singular Wishart matrix case. We apply our findings to obtain a 95% confidence set for the number of common risk factors in excess stock returns.