Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of feedback regarding urinary cotinine and brief tailored advice on home smoking restrictions among low-income parents of children with asthma: a controlled trial.

BACKGROUND Since most smoker parents of children with asthma are unable to quit, an alternative measure that would reduce their children's exposure to environmental tobacco smoke (ETS) is to ban smoking in the home. METHODS Compared with 136 usual-care controls, 128 intervention-group parents recruited from South Australian pediatric hospital outpatient waiting rooms were given written and verbal feedback about their 1- to 11-year-old child's urinary cotinine-to-creatinine level, information booklets, and two telephone calls encouraging a ban on smoking at home. RESULTS At 6 months, 49.2% of the intervention group reported having banned smoking in the home compared with 41.9% of controls, but the differential rate of change from baseline was not significant (P = 0.40). At follow-up, there were no significant differences between groups in the percentage reporting bans on smoking in the car, the mean reduction from baseline in total daily consumption or consumption in front of the child, children's urinary cotinine level, or parental smoking cessation. CONCLUSIONS The intervention did not change parents' propensity to create or maintain bans on smoking in their homes or otherwise change smoking habits to reduce their children's exposure to ETS. More intensive interventions may be required to achieve change among low-income smoker parents of children with asthma.
Motivations for seeking minimally invasive cosmetic procedures in an academic outpatient setting.

BACKGROUND The demand for minimally invasive cosmetic procedures has continued to rise, yet few studies have examined this patient population. OBJECTIVES This study sought to define the demographics, social characteristics, and motivations of patients seeking minimally invasive facial cosmetic procedures. METHODS A prospective, single-institution cohort study of 72 patients was conducted from 2011 through 2014 at an urban academic medical center. Patients were aged 25 through 70 years; presented for botulinum toxin or soft tissue filler injections; and completed demographic, informational, and psychometric questionnaires before treatment. Descriptive statistics were conducted using Stata statistical software. RESULTS The average patient was 47.8 years old, was married, had children, was employed, possessed a college or advanced degree, and reported an above-average income. Most patients felt that the first signs of aging occurred around their eyes (74.6%), and a similar percentage expressed this area was the site most desired for rejuvenation. Almost one-third of patients experienced a "major life event" within the preceding year, nearly half had sought prior counseling from a mental health specialist, and 23.6% were being actively prescribed psychiatric medication at the time of treatment. CONCLUSIONS Patients undergoing injectable aesthetic treatments in an urban outpatient academic center were mostly employed, highly educated, affluent women who believed that their procedure would positively impact their appearance. A significant minority experienced a major life event within the past year, which an astute clinician should address during the initial patient consultation. This study helps to better understand the psychosocial factors characterizing this patient population. LEVEL OF EVIDENCE 4 Therapeutic.
Validation of a one-day self-report questionnaire for physical activity assessment in healthy adults

Abstract A self-report physical activity scale (PAS) has previously been developed to document physical activity (MET-hours) undertaken by adults during an average weekday. The current study aimed to validate the PAS over 24 hours via pedometer determinations of physical activity in healthy, active adults, and to determine possible influences of gender and body mass status on this relationship. One-hundred and seven healthy university students (age 18–41 years) wore a pedometer (Yamax DigiWalker SW-700) during the waking hours of an average weekday followed by successful completion of the PAS. Relationships between the PAS and pedometer measures (steps taken and energy expenditure) were examined by Pearson's correlation coefficients. Significant (P<0.05) gender and body mass status differences were examined by two-way analysis of variance with Tukey post-hoc tests. Participants reported 48.0±10.4 MET-hours of activity, completed 11,506±4195 steps, and expended 499±227 kcal during an average weekday. Physical activity measures, except energy expenditure, were similar across groups by gender and body mass status. The total number of MET-hours was significantly associated with pedometer steps taken (r=0.375–0.568, P<0.01), and this relationship varied by gender and to a lesser extent by body mass status. The results of the current study show that the self-reported physical activity of healthy active adults was in line with the popular recommended dose of daily physical activity (10,000 steps per day) and was not influenced by gender or body mass status. Furthermore, over an average weekday, the PAS provided a simple, quick, and valid method to document physical activity undertaken by young healthy active adults that is comparable to pedometer readings.
Exploring lecturers’ perception on learning organization dimensions and demographic variables in technical and vocational colleges

The purpose of this study was to explore the perception of 295 lecturers on learning organization dimensions and demographic variables in technical and vocational colleges in four provinces of Fars, Khuzestan, Boushehr, and Kohgilouyeh and Boyerahmad in Iran. Data was collected using a questionnaire and analyzed utilizing SPSS which included the use of descriptive and inferential statistics. The findings showed that respondents’ perceptions were rated from moderate to high in learning organization dimensions with significant differences based on the type of employment, academic rank and education level. No significant differences were observed in gender and marital status towards learning organization dimensions. The relevant literature shows few studies regarding learning organization dimensions and demographic variables locally and internationally. Therefore, the findings can be evaluated as useful information and guidance for educational administrators and leaders in utilizing learning organization dimensions in the management of educational institutions.
Differential cytotoxicity, uptake and DNA binding of tetraplatin and analogous isomers in sensitive and resistant cancer cell lines.

Some platinum complexes contain 1,2-diaminocyclohexane (DACH) as a stable carrier ligand, which can exist as the R,R-, S,S- and cis-isomers. Tetraplatin, for instance, is a mixture of R,R- and S,S-DACH-Cl4-Pt(IV). We have examined each of the three individual isomers of DACH-Cl4-Pt(IV) with respect to cytotoxicity, uptake of platinum and total DNA-platinum in three murine leukemia L1210 (cisplatin-sensitive L1210/0, 50-fold cisplatin-resistant L1210/DDP and 36-fold tetraplatin-resistant L1210/DACH) and human ovarian carcinoma A2780 (cisplatin-sensitive) and A2780cp (8-fold cisplatin-resistant) cell lines. Against A2780, A2780cp and L1210/DDP cell lines, the R,R-isomer was the most potent followed by the S,S-isomer and then the cis-isomer. However, the three isomers demonstrated similar IC50 values against the L1210/0 and L1210/DACH cell lines. The cis-isomer demonstrated cross-resistance (9- to 20-fold) to cisplatin in L1210/DDP and A2780cp cell lines. On the other hand, R,R- and S,S-isomers demonstrated minimal (2- to 4-fold) cross-resistance against these tumor models. Intracellular platinum accumulation over a 2 h period at 40 microM drug concentration was significantly (p < 0.05) greater for the R,R-isomer than the cis-isomer in L1210/0 (122 versus 101 ng Pt/mg protein) and L1210/DDP (73 versus 50) cell lines, while no difference was observed in L1210/DACH cells (55 versus 56). In L1210/DDP cells, total DNA-bound platinum was significantly (p < 0.05) greater for the R,R-isomer compared with the cis-isomer (10.3 versus 7.5 ng Pt/mg DNA). (ABSTRACT TRUNCATED AT 250 WORDS)
The Mediating Effects of Organizational and Supervisor Identification for Interactional Justice

Interactional justice is an important management issue for government agencies because it arises from daily interpersonal interactions and thus affects subsequent working outcomes of civil servants. This study is aimed to investigate the differential mediating effects of organizational identification and supervisor identification to explain why interactional justice affects both organization-focused and supervisor-focused outcomes. Specifically, we predicted that organizational identification would mediate the association between interactional justice and organization-focused outcome (organizational citizenship behaviors directed at the organization), whereas supervisor identification would mediate the association between interactional justice and supervisor-focused outcomes (supervisor evaluation and organizational citizenship behaviors directed at the supervisor). To examine our hypotheses, we carried out a filed survey study and collected data from local civil servants in Sichuan province of China. Results supported our hypotheses. We discussed our study’s conceptual contributions and its practical implications for human resource management in government agencies, and pointed out directions for further research.
An impaired renal function and advanced heart failure represent independent predictors of the incidence of malignant ventricular arrhythmias in patients with an implantable cardioverter/defibrillator for primary prevention.

AIMS Malignant ventricular arrhythmias and inappropriate therapies represent unsolved problems in patients with implantable cardioverter/defibrillator (ICD) for primary prevention. This study focuses on the incidence of such therapies and thereby seeks to identify new predictors of adverse events to enhance risk stratification. METHODS AND RESULTS Ninety-four consecutive patients with mild-to-moderate heart failure (NYHA II-III) and depressed left ventricular function (≤35%) were followed for 34 ± 20 months. Two hundred and ninety-one malignant ventricular arrhythmias were documented in 51 patients (54%). Eighteen patients (19%) received inappropriate ICD therapies (e.g. atrial fibrillation, sinus tachycardia, etc.). Patients with malignant arrhythmia (1.34 ± 0.44 vs. 1.16 ± 0.4 mg/dL, P = 0.017) and patients suffering from inappropriate ICD therapies (1.54 ± 0.48 vs. 1.2 ± 0.38 mg/dL; P = 0.007) revealed a significantly worse renal function before ICD implantation than participants without any therapy. An increased serum creatinine at baseline (2 vs. 1 mg/dL; odds ratio (OR) 3.96; P = 0.02; 95% CI: 1.2-13.04) and NHYA class III compared with II (OR: 2.96; P = 0.02; 95% CI: 1.16-7.48) represent strong and independent predictors for the occurrence of ventricular arrhythmias. Moreover, an impaired renal function is identified as an independent risk factor for inappropriate therapies (OR: 5.6; P = 0.004; 95% CI: 1.72-18.22). CONCLUSION An impaired renal function and advanced heart failure before ICD implantation for primary prevention are identified as independent predictors for the incidence of appropriate ICD interventions. With regard to current guidelines and economical aspects, patients suffering from an impaired renal function or advanced heart failure seem to benefit most from ICD therapy.
The development of two types of inhibitory control in monolingual and bilingual children*

Previous research has shown that bilingual children excel in tasks requiring inhibitory control to ignore a misleading perceptual cue. The present series of studies extends this finding by identifying the degree and type of inhibitory control for which bilingual children demonstrate this advantage. Study 1 replicated the earlier research by showing that bilingual children perform the Simon task more rapidly than monolinguals, but only on conditions in which the demands for inhibitory control were high. The next two studies compared performance on tasks that required inhibition of attention to a specific cue, like the Simon task, and inhibition of a habitual response, like the day–night Stroop task. In both studies, bilingual children maintained their advantage on tasks that require control of attention but showed no advantage on tasks that required inhibition of response. These results confine the bilingual advantage found previously to complex tasks requiring control over attention to competing cues (interference suppression) and not to tasks requiring control over competing responses (response inhibition).
Characterization of non-beta-lactamase-mediated ampicillin resistance in Haemophilus influenzae

Ampicillin resistance in Haemophilus influenzae is most often due to the plasmid-mediated production of TEM beta-lactamase. We studied four strains with high-level ampicillin resistance (MIC of 32 micrograms/ml with an inoculum of 10(5) CFU on solid media) which did not produce detectable beta-lactamase activity with two different detection methods. Two of the four strains contained extrachromosomal DNA by agarose gel electrophoresis. Conjugation failed to transfer ampicillin resistance; in contrast, transformation yielded ampicillin-resistant transformants in three of the four strains. These transformants did not contain detectable extrachromosomal DNA. In addition, mobilization of the resistance determinant by transformation to, or conjugation with, recombination-deficient strains was unsuccessful. DNA-DNA hybridization experiments revealed no homology of the DNA of these strains with two R plasmids (one coding for ampicillin resistance, the other for chloramphenicol and tetracycline resistance). We conclude that the genetic basis of the non-beta-lactamase ampicillin resistance in these strains appears to be chromosomally mediated. We investigated the mechanism of resistance in these strains. Enzymatic modification of penicillin was not detected by autoradiography of a thin-layer chromatogram of cell sonic extracts of three ampicillin-resistant transformant strains incubated with [14C]penicillin. To assess changes in permeability of the cell envelope, a plasmid coding for beta-lactamase was conjugated into these strains, and the hydrolysis of penicillin by intact cells and cell sonic extracts was compared. Only one of three transformant strains had significantly diminished permeability. Outer membrane proteins of these strains analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis revealed apparent differences in comparison with the isogenic ampicillin-susceptible recipient strain. Autofluorography of a sodium dodecyl sulfate-polyacrylamide gel electrophoresis of Sarkosyl-solubilized crude membrane (the putative inner membranes) from these ampicillin-resistant transformant strains incubated with [3H]penicillin compared with the isogenic ampicillin-susceptible recipient strain revealed reduced binding to PBP 3 and 6, 3 and 4, or 4. In addition, affinity binding studies revealed decreased affinity of PBP 4 for ampicillin of all four transformants tested. We conclude that the major mechanism of resistance in these strains is altered penicillin-binding proteins; however, other mechanisms, including permeability, may also play a role.
The Dry Season in Haiti: a Window of Opportunity to Eliminate Cholera

Background: Since the beginning of the cholera epidemic in Haiti, attack rates have varied drastically with alternating peak and lull phases, which were partly associated with the fluctuating dry, rainy and cyclonic seasons. According to a study conducted in 2012, the toxigenic V. cholerae O1 strain responsible for the outbreak did not settle at a significant level in the Haitian aquatic environment. Therefore, we hypothesize that some areas of lingering cholera transmission during the dry season could play an important role in the re-emergence of outbreaks during the rainy season. Our objective was therefore to describe the dynamics of cholera and assess the fight against the disease during the dry season. Methods: A field study was conducted from February 19 to March 29, 2013. After identifying the affected communes by analyzing the national cholera database, we visited corresponding health facilities to identify patient origins. We then conducted a field assessment of these foci to confirm the presence of cholera, assess factors associated with transmission and examine the activities implemented to control the epidemic since the beginning of the current dry season. Results: We found that the great majority of Haitian communes (109/140) presented no sign of cholera transmission in February and March 2013. Suspected cases were concentrated in a small number of urban and rural areas, almost all of which were located in the northern half of the country and often in inland locales. In these areas, community health activities appeared insufficient and were often inappropriately targeted. Out of 49 analyzed foci, only 10 had benefited from at least one intervention involving the distribution of water treatment products together with an awareness campaign since December 2012. Conclusion: Cholera continues to affect Haiti as observed in early 2013; however, activities implemented to interrupt cholera transmission appear insufficient and poorly suited. This deficiency in the fight against cholera, especially at a period when transmission is weak, may explain the persistence of cholera even in the absence of significant aquatic reservoirs in Haiti.
What's Happening to the Boys?

This article examines the transition to high school among African American males who were part of a longitudinal study in Chicago. It begins with a comparison of gender differences in school performance from 8th to 12th grade. It then presents an in-depth qualitative look at the experiences of the 15 males in the longitudinal study. In 8th grade, there were few gender differences in school performance or teachers' ratings of students' behavior and skills. African American males experienced much more dramatic declines than females in their grades between 8th and 9th grade and were viewed more negatively by their 9th grade teachers. Ultimately, only 40% of the males graduated compared to 80% of the females. By looking carefully at individual students' experiences, this article seeks to gain insight into the school, peer, familial and developmental processes that shape the school performance of African American males over this critical period.
Water and bottom properties of a coastal environment derived from Hyperion data measured from the EO-1 spacecraft platform

Hyperion is a hyperspectral sensor on board NASA's EO-1 satellite with a spatial resolution of approximately 30 m and a swath width of about 7 km. It was originally designed for land applications, but its unique spectral configuration (430 nm - 2400 nm with a ~10 nm spectral resolution) and high spatial resolution make it attractive for studying complex coastal ecosystems, which require such a sensor for accurate retrieval of environmental properties. In this paper, Hyperion data over an area of the Florida Keys is used to develop and test algorithms for atmospheric correction and for retrieval of subsurface properties. Remote-sensing reflectance derived from Hyperion data is compared with those from in situ measurements. Furthermore, water's absorption coefficients and bathymetry derived from Hyperion imagery are compared with sample measurements and LIDAR survey, respectively. For a depth range of ~ 1 - 25 m, the Hyperion bathymetry match LIDAR data very well (~11% average error); while the absorption coefficients differ by ~16.5% (in a range of 0.04 - 0.7 m -1 for wavelengths of 410, 440, 490, 510, and 530 nm) on average. More importantly, in this top-to-bottom processing of Hyperion imagery, there is no use of any a priori or ground truth information. The results demonstrate the usefulness of such space-borne hyperspectral data and the techniques developed for effective and repetitive observation of complex coastal regions.
Profile of Escherichia coli O157:H7 pathogen responsible for hamburger-borne outbreak of hemorrhagic colitis and hemolytic uremic syndrome in Washington

We analyzed Escherichia coli O157:H7 isolates from stool samples of five patients who had bloody diarrhea and were infected during a large food-borne outbreak of hemorrhagic colitis in Washington state. The isolates were assessed for Shiga-like toxin profile, adherence and plasmid traits, mouse virulence, capsule, and enterohemolysin production. The profiles of the five isolates were indistinguishable from each other and similar to that of E. coli O157:H7 strain EDL933, an organism responsible for a similar hamburger-associated food poisoning episode in 1982.
Unleashing angst: Negative mood, learning goal orientation, psychological empowerment and creative behaviour

Emotion researchers have found that negative mood may either enhance or inhibit employee creativity. Little is known about this conundrum, however, and in particular when and why each effect occurs. To address this concern, we formulate and test hypotheses about likely moderators of the relationship between negative mood and creative process engagement. Results from an experience sampling study with 556 real-time reports from 68 employees support our hypothesis that negative mood is most strongly and positively related to concurrent creative process engagement among employees who (a) have high trait learning goal orientation and (b) perceive that they are empowered. Our hypotheses and findings help to resolve the ongoing controversy surrounding the nature of the negative mood–creativity nexus.
The Neural Correlates of Subjective Utility of Monetary Outcome and Probability Weight in Economic and in Motor Decision under Risk

In decision under risk, people choose between lotteries that contain a list of potential outcomes paired with their probabilities of occurrence. We previously developed a method for translating such lotteries to mathematically equivalent “motor lotteries. ” The probability of each outcome in a motor lottery is determined by the subject's noise in executing a movement. In this study, we used functional magnetic resonance imaging in humans to compare the neural correlates of monetary outcome and probability in classical lottery tasks in which information about probability was explicitly communicated to the subjects and in mathematically equivalent motor lottery tasks in which probability was implicit in the subjects' own motor noise. We found that activity in the medial prefrontal cortex (mPFC) and the posterior cingulate cortex quantitatively represent the subjective utility of monetary outcome in both tasks. For probability, we found that the mPFC significantly tracked the distortion of such information in both tasks. Specifically, activity in mPFC represents probability information but not the physical properties of the stimuli correlated with this information. Together, the results demonstrate that mPFC represents probability from two distinct forms of decision under risk.
Analysis of antibody diversity: V‐D‐J mRNA nucleotide sequence of four anti‐GAT monoclonal antibodies. A paucigene system using alternate D‐J recombinations to generate functionally similar hypervariable regions.

The nucleotide sequence of four anti‐(Glu60‐Ala30‐Tyr10)n (GAT) monoclonal gamma 1 heavy chain mRNAs was determined from codon 10 to 120. This sequence overlaps with the NH2‐terminal amino acid sequence, allowing elucidation of the complete protein sequence encompassing regions VH, D and JH. These sequences, which are highly conserved, indicate that anti‐GAT antibodies expressing the same public idiotypic specificities represent a paucigene system, which uses at least two D‐J combinations leading to functionally similar hypervariable regions involved in the recognition of the dominant Glu‐Tyr determinant. D regions are encoded by D genes which are closely related either to the D‐SP2 or the D.FL16 germ line gene cores.