Miracle-dz/UniFAR-FTUs huggingface dataset:
The role of working memory capacity in the development of L2 speech production

This study addresses the question of how working memory capacity and L2 speech production covary over a period of time, during learners’ L2 speech development. Participants were submitted to two data collection phases, each one consisting of a working memory test (an adaptation of Daneman’s 1991 speaking span test) and a speech generation task, with a twelveweek interval between the two data collections. The results show that both lower and higher span individuals experienced some increase in L2 speech production scores in between phases. However, only lower span participants had a statistically significant improvement in working memory scores over trials. In addition, the speaking span test was related to the development of complexity in speakers’ L2 speech.
You get what you expect? A critical appraisal of imaging methodology in endosonographic cancer staging

Background and aims: After an initial period of excellent results with newly introduced imaging procedures, the accuracy of most imaging methods declines in later publications. This effect may be due to various methodological factors involved in the research. Using the example of endoscopic ultrasound (EUS), this study aimed to elucidate one of the factors possibly concerned—namely, the extent to which the examiners are adequately blinded. Methods: Well documented videotapes of EUS examinations of 101 patients with resected tumours of the oesophagus (n=32), stomach (n=33), or pancreas (n=36) were evaluated in three different ways: firstly, retrospective analysis under routine clinical conditions; secondly, evaluation of EUS videotapes in a strictly blinded fashion; and thirdly, evaluation of the same videotapes but with additional information from the video endoscopic appearance (oesophageal/gastric cancer) or from computed tomography results (pancreatic cancer). Histopathological T staging was used as the reference method. Results: The accuracy of EUS in T staging was 73% under routine conditions. This value fell significantly to 53% for the blinded evaluation but increased again to 62% for the unblinded evaluation. The sensitivity of staging T1/T2 tumours was 72% (routine EUS), 59% (blinded EUS), and 70% (unblinded EUS). The respective values for advanced tumours were 85%, 74%, and 72%. Conclusions: The accuracy of EUS for T staging in clinical practice appears to be lower than has previously been reported. In addition, blinded analysis produced significantly poorer results, which improved when another test was added. It may be speculated that better results with routine EUS obtained in a clinical setting are due to additional sources of information.
Language, interaction and social cognition

The importance of language is increasingly acknowledged within social psychology. In this seminal book, a group of distinguished authors goes beyond general theory to address, from a research base, key issues in the interrelationship between language, interaction and social cognition. Their starting point is that the ways in which we perceive and, therefore, interact with others are structured by the language available to us, as a socially constructed system above and beyond individual minds. The relationship between language and social cognition is not, however, a fixed or unicausal one: linguistic terms are also generated in response to social and cultural development. The interplay is dialectical - a dialectic of the social. The authors explore this dialectic through such themes as: the use and power of category labels; trait-behaviour relations in social information processing; and interpersonal verbs and attribution. They examine the significance of language use in the persistence of stereotypes, and the links between syntactical reasoning processes and social cognition, as well as the impact of perspectivity. They consider the ways in which communication roles and context shape, and are shaped by, language. Language, Interaction and Social Cognition will be essential reading for all those in social psychology, psycholinguistics, linguistics and communication studies concerned with the role of language in interaction and social cognition.
Reactive Oxygen Species Mediate Amplitude-Dependent Hypertrophic and Apoptotic Responses to Mechanical Stretch in Cardiac Myocytes

Oxidative stress stimulates both growth and apoptosis in cardiac myocytes in vitro. We investigated whether oxidative stress mediates hypertrophy and apoptosis in cyclically stretched ventricular myocytes. Neonatal rat ventricular myocytes cultured on laminin-coated silastic membranes were stretched cyclically (1 Hz) at low (nominal 5%) and high (nominal 25%) amplitudes for 24 hours. Stretch caused a graded increase in superoxide anion production as assessed by superoxide dismutase (SOD)-inhibitable cytochrome c reduction or electron paramagnetic resonance spectroscopy. The role of reactive oxygen species (ROS) was assessed using the cell-permeable SOD/catalase mimetics Mn(II/III)tetrakis(1-methyl-4-peridyl) (MnTMPyP) and EUK-8. Stretch-induced increases in protein synthesis (3H-leucine incorporation) and cellular protein content were completely inhibited by MnTMPyP (0.05 mmol/L) at both low and high amplitudes of stretch. In contrast, while MnTMPyP inhibited basal atrial natriuretic factor (ANF) mRNA expression, the stretch-induced increase in ANF mRNA expression was not inhibited by MnTMPyP. In contrast to hypertrophy, only high-amplitude stretch increased myocyte apoptosis, as reflected by increased DNA fragmentation on gel electrophoresis and an ≈3-fold increase in the number of TUNEL-positive myocytes. Similarly, only high-amplitude stretch increased the expression of bax mRNA. Myocyte apoptosis and bax expression stimulated by high-amplitude stretch were inhibited by MnTMPyP. Both low- and high-amplitude stretch caused rapid phosphorylation of ERK1/2, while high-, but not low-, amplitude stretch caused phosphorylation of JNKs. Activation of both ERK1/2 and JNKs was ROS-dependent. Thus, cyclic strain causes an amplitude-related increase in ROS, associated with differential activation of kinases and induction of hypertrophic and apoptotic phenotypes.
Peer and friend influences on eating behaviour in school children

Currently there is limited research addressing the eating behaviours of preadolescent children, despite evidence suggesting that friends and peers may contribute to the developing eating attitudes and behaviours of children of this age. Eating behaviours in terms of this thesis include both under- and over- eating behaviours, with a specific focus on the under-eating behaviour, dietary restraint, and the over-eating behaviours emotional eating and external eating. The fundamental aim of this thesis was to examine friend and peer influences on children s eating behaviours, with a specific focus on a community sample of preadolescent children. Based on links established in the literature between childhood eating behaviours (dietary restraint, emotional eating and external eating) and parental controlling feeding practices (pressure to eat and restriction) and childhood symptoms of anxiety and depression, these factors were also considered alongside the contribution of friends and peers, both cross-sectionally and longitudinally. The longitudinal stability and continuity of self-reported eating behaviours and perceived parental feeding practices in preadolescent children were also examined in this thesis. A pilot study and experimental study provided an objective measure of children s snack food intake following a school lunchtime, when offered a selection (healthy and unhealthy) of snack foods in the presence of friends and peers. Links between food intake in the presence of friends and peers, and self-reported eating behaviours, parental controlling feeding practices, child symptoms of anxiety and depression and BMI were further explored. The research in this thesis suggests that friends dieting behaviours predict individual children s dieting behaviours, and also highlights links between problematic eating and anxiety in preadolescent children. Parental controlling feeding practices were found to have a negative impact on preadolescents eating behaviours and were also found to be potentially linked to the development or maintenance of anxiety and depression symptoms in children of this age. Preadolescents reports of eating behaviours and perceptions of the controlling feeding practices their parents utilised with them were stable over time, but, with the exception of restriction, lacked continuity. Dietary restraint, emotional eating and external eating decreased over a 12 month period. While some of the research in this thesis requires replication, the results present many novel and interesting findings. Using longitudinal and experimental data, the research reported on in this thesis highlights the important contributions of friends, peers, parents and individual anxiety and low mood to the eating attitudes and behaviours of preadolescent aged children.
The biology of mammalian parenting and its effect on offspring social development

Parents know the transformative nature of having and caring for a child. Among many mammals, giving birth leads from an aversion to infant stimuli to irresistible attraction. Here, we review the biological mechanisms governing this shift in parental motivation in mammals. Estrogen and progesterone prepare the uterus for embryo implantation and placental development. Prolactin stimulates milk production, whereas oxytocin initiates labor and triggers milk ejection during nursing. These same molecules, interacting with dopamine, also activate specific neural pathways to motivate parents to nurture, bond with, and protect their offspring. Parenting in turn shapes the neural development of the infant social brain. Recent work suggests that many of the principles governing parental behavior and its effect on infant development are conserved from rodent to humans.
John Ludbrook APPS Symposium Neural Mechanisms In The Cardiovascular Responses To Acute Central Hypovolaemia

1. The haemodynamic response to acute central hypovolaemia consists of two phases. During phase I, arterial pressure is well maintained in the face of falling cardiac output (CO) by baroreceptor‐mediated reflex vasoconstriction and cardio‐acceleration. Phase II commences once CO has fallen to a critical level of 50–60% of its resting value, equivalent to loss of approximately 30% of blood volume.
Hierarchical bottle neck features for LVCSR

This paper investigates the combination of different neural network topologies for probabilistic feature extraction. On one hand, a five-layer neural network used in bottle neck feature extraction allows to obtain arbitrary feature size without dimensionality reduction by transform, independently of the training targets. On the other hand, a hierarchical processing technique is effective and robust over several conditions. Even though the hierarchical and bottle neck processing performs equally well, the combination of both topologies improves the system by 5% relative. Furthermore, the MFCC baseline system is improved by up to 20% relative. This behaviour could be confirmed on two different tasks. In addition, we analyse the influence of multi-resolution RASTA filtering and long-term spectral features as input for the neural network feature extraction. Index Terms: probabilistic features, bottle neck, hierarchical processing, LVCSR
The Age of Reason: Financial Decisions over the Life-Cycle with Implications for Regulation

Many consumers make poor financial choices and older adults are particularly vulnerable to such errors. About half of the population between ages 80 and 89 either has dementia or a medical diagnosis of "cognitive impairment without dementia. " We study lifecycle patterns in financial mistakes using a proprietary database that measures ten different types of credit behavior. Financial mistakes include suboptimal use of credit card balance transfer offers, misestimation of the value of one's house, and excess interest rate and fee payments. In a cross-section of prime borrowers, middle-aged adults make fewer financial mistakes than younger and older adults. We conclude that financial mistakes follow a U-shaped pattern, with the cost-minimizing performance occurring around age 53. We analyze regulatory regimes that may help individuals avoid making financial mistakes. Some of these regimes are designed to address the particular challenges faced by older adults, but much of our discussion is relevant for all vulnerable populations. We discuss disclosure, nudges, financial driving licenses, advanced directives, fiduciaries, asset safe harbors, ex-post and ex-ante regulatory oversight. Finally, we pose seven questions for future research on cognitive limitations and associated policy responses.
Copeland Dueling Bandit Problem: Regret Lower Bound, Optimal Algorithm, and Computationally Efficient Algorithm

We study the K-armed dueling bandit problem, a variation of the standard stochastic bandit problem where the feedback is limited to relative comparisons of a pair of arms. The hardness of recommending Copeland winners, the arms that beat the greatest number of other arms, is characterized by deriving an asymptotic regret bound. We propose Copeland Winners Relative Minimum Empirical Divergence (CW-RMED) and derive an asymptotically optimal regret bound for it. However, it is not known whether the algorithm can be efficiently computed or not. To address this issue, we devise an efficient version (ECW-RMED) and derive its asymptotic regret bound. Experimental comparisons of dueling bandit algorithms show that ECW-RMED significantly outperforms existing ones.
Comparing fine-grained source code changes and code churn for bug prediction

A significant amount of research effort has been dedicated to learning prediction models that allow project managers to efficiently allocate resources to those parts of a software system that most likely are bug-prone and therefore critical. Prominent measures for building bug prediction models are product measures, e.g., complexity or process measures, such as code churn. Code churn in terms of lines modified (LM) and past changes turned out to be significant indicators of bugs. However, these measures are rather imprecise and do not reflect all the detailed changes of particular source code entities during maintenance activities. In this paper, we explore the advantage of using fine-grained source code changes (SCC) for bug prediction. SCC captures the exact code changes and their semantics down to statement level. We present a series of experiments using different machine learning algorithms with a dataset from the Eclipse platform to empirically evaluate the performance of SCC and LM. The results show that SCC outperforms LM for learning bug prediction models.
Her-2-neu expression and progression toward androgen independence in human prostate cancer.

BACKGROUND Human prostate cancers are initially androgen dependent but ultimately become androgen independent. Overexpression of the Her-2-neu receptor tyrosine kinase has been associated with the progression to androgen independence in prostate cancer cells. We examined the expression of Her-2-neu in normal and cancerous prostate tissues to assess its role in the progression to androgen independence. METHODS Prostate cancer tissue sections were obtained from 67 patients treated by surgery alone (UNT tumors), 34 patients treated with total androgen ablation therapy before surgery (TAA tumors), and 18 patients in whom total androgen ablation therapy failed and who developed bone metastases (androgen-independent [AI] disease). The sections were immunostained for Her-2-neu, androgen receptor (AR), prostate-specific antigen (PSA), and Ki-67 (a marker of cell proliferation) protein expression. Messenger RNA (mRNA) levels and gene amplification of Her-2-neu were examined by RNA in situ hybridization and fluorescent in situ hybridization(FISH), respectively, in a subset of 27 tumors (nine UNT, 11 TAA, and seven AI). All statistical tests were two-sided. RESULTS Her-2-neu protein expression was statistically significantly higher in TAA tumors than in UNT tumors with the use of two different scoring methods (P =.008 and P =.002). The proportion of Her-2-neu-positive tumors increased from the UNT group (17 of 67) to the TAA group (20 of 34) to the AI group (14 of 18) (P<.001). When compared with UNT tumors, tumor cell proliferation was higher in AI tumors (P =.014) and lower in TAA tumors (P<.001). All tumors expressed AR and PSA proteins. Although Her-2-neu mRNA expression was high in TAA and AI tumors, no Her-2-neu gene amplification was detected by FISH in any of the tumor types. CONCLUSIONS Her-2-neu expression appears to increase with progression to androgen independence. Thus, therapeutic targeting of this tyrosine kinase in prostate cancer may be warranted.
Parallel Information Processing in the Dorsal Striatum: Relation to Hippocampal Function

We investigated the effects of localized medial and lateral CPu lesions and fornix/fimbria lesions on responses to a local cue and to behavior based on cognitive–spatial information in the water maze. Rats were trained concurrently on the cue (visible platform) and spatial (submerged platform) components of the task, followed by a test in which responses to the two types of information were dissociated by a measure of competing response tendencies. Bilateral lesions of lateral CPu did not affect acquisition of either cue or spatial responding but produced a preference for the spatial response on the competition test. Bilateral lesions of the medial CPu retarded but did not prevent learning both components and produced a preference for the cue response on the competition test. The latter effect was accompanied by increased thigmotaxis (swimming in the periphery of the pool), primarily during the early acquisition trials, which was attributed to an impaired ability to respond to learned spatial information. Fornix/fimbria lesions prevented spatial but not cue learning and produced a preference for the cue response on the competition test. Asymmetric lesions (unilateral hippocampus and contralateral medial CPu) produced mild retardation of acquisition of both the cue and spatial tasks and a preference for the cue response on the competition test. These findings dissociate the functions of the lateral and medial CPu and suggest that the hippocampus and medial CPu may be parts of a system that promotes responding based on learned cognitive–spatial information, particularly in competitive cue–place response situations.
Identification of Anaplasma spp. Rickettsia Isolated from Horses from Clinical Disease Cases in Poland

This study was aimed at determining the cause of the diseases in five horses exhibiting symptoms of fever, joint oedema and ataxia and thrombocytopenia. The PCR technique revealed the presence in the blood of 16S RNA Anaplasma/Ehrlichia spp. genetic material. DNA amplification with primers EHR 521 and EHR 747 gave a product with a size of 247 bp. The sequence of the PCR product obtained showed a 97.6–99.6% similarity with a sequence of a fragment of 16S RNA Anaplasma phagocytophilum, gene number EU 090186 from GenBank. Intravenous administration of oxytetracycline at a dose of 8 mg/kg of body mass for 7 days resulted in a gradual recovery.
Laparoscopic Fundoplication for Gastroesophageal Reflux: Effects on Esophageal Motility

Laparoscopic Nissen-Rossetti fundoplication is now recognized as a valid therapy for the treatment of gastroesophageal reflux disease. This retrospective study evaluates the effects of laparoscopic fundoplication on esophageal motility and correlates these effects to postsurgical symptoms. A total of 123 patients underwent laparoscopic fundoplication at our institution. Pre-and postoperative esophageal manometric data were analyzed with regard to the effect of surgery and postsurgical outcome. Postoperative lower esophageal sphincter pressure was significantly increased compared wtih preoperative values (1.7 ± 0.8 kPa vs 0.9 ± 0.7 kPa). Duration and amplitude of esophageal body contractions were not modified. The percentage of deglutition-induced complete peristaltic waves and the velocity of propagation were significantly decreased after surgery (P < 0.05). Postoperative symptoms were significantly correlated with postoperative lower esophageal sphincter pressure only. Laparoscopic fundoplication significantly increases lower esophageal sphincter pressure. It significantly decreases esophageal body peristaltic efficiency, a decrease that is most likely of minor clinical significance.
Lysine at position 222 of the goat prion protein inhibits the binding of monoclonal antibody F99/97.6.1

Prion protein (PrP) is encoded by the PRNP gene, which is highly polymorphic in goats, with polymorphisms encoding amino acid substitutions at the protein level. In the current study, the reactivity of monoclonal antibody (mAb) F99/97.6. 1 in binding PrP from goats polymorphic at PRNP codon 222 was investigated. Nervous tissue from 30 scrapie-negative goats with 3 different genotypes (222Q/Q, 222Q/K, and 222K/K) was analyzed by Western blot using mAbs P4 and F99/97.6. 1. Although PrP was detected in all 30 samples by mAb P4, detection of PrP by mAb F99/97.6. 1 was limited to 222Q/Q (12/12). No PrP was detected by mAb F99/97.6. 1 in the 222K/K samples (n = 6), and the signal intensity of mAb F99/97.6. 1 for PrP was lower for the 222Q/K samples (12/12 samples). To further investigate these results, additional Western blot analyses were performed, and the PrP signals detected by mAbs F99/97.6. 1 and SAF84 were then quantified. The mean F99/SAF84 ratio (± standard deviation) calculated for the 222Q/Q group was 0.73 ± 1.26, and the mean for the 222Q/K group was 0.27 ± 1.31. Statistical analysis of these values evidenced statistically significant differences between the 222Q/Q and 222Q/K samples. The results of the study thus revealed an inhibition by lysine at position 222 on the binding of mAb F99/97.6. 1 to goat PrP. This has implications for the use of mAb F99/97.6. 1 for diagnostic purposes. Because the 222K allele could be a target for genetic selection in goats, the differential reactivity of mAb F99/97.6. 1 could be exploited with a genotyping test setup.
Primary teacher education in England: 40 years on

This article examines the relationship between pre-service teacher education (ITE) for primary schooling and primary teaching in England between 1974 and 2014, and explores the ‘fitness of purpose’ of the current system of preparing teachers for the classrooms of the twenty-first century. Our historical analysis suggests that, despite 40 years of change in ITE, there are still a number of unresolved issues in ITE. These include: how to prepare for the multisubject, class teacher role which the majority of primary teachers still undertake; how to equip future teachers to deal with the social and emotional aspects of primary teaching; how to ensure that they are creative and flexible practitioners, able to cope with the demands of future curricula, pedagogical changes and the new roles and responsibilities which will inevitably occur during the course of their teaching careers in the next decades of this century; and how to structure ITE to provide adequate long-term foundations for the necessary professional development as a teacher.