Miracle-dz/UniFAR-FTUs huggingface dataset:
Learning Discriminative Metrics via Generative Models and Kernel Learning

AbstractMetrics specifying distances between data points can be learned in a discriminative manner or fromgenerative models. In this paper, we show how to unify generative and discriminative learning of met-rics via a kernel learning framework. Speciﬁcally, we learn local metrics optimized from parametricgenerative models. These are then used as base kernels to construct a global kernel that minimizes adiscriminative training criterion. We consider both linear and nonlinear combinations of local metrickernels. Our empirical results show that these combinations signiﬁcantly improve performance on clas-siﬁcation tasks. The proposed learning algorithm is also ve ry efﬁcient, achieving order of magnitudespeedup in training time compared to previous discriminative baseline methods. 1 Introduction Metric learning – learning how to specify distances between data points – has been a topic of much interestin machine learning recently. For example, discriminative techniques for metric learning aim to improvethe performance of a classiﬁer, such as the k-nearest neighbor classiﬁer, on a training set. As a generalstrategy, these techniques try to reduce the distances between data points belonging to the same class whileincreasing the distances between data points from different classes [1, 2, 3, 4, 5, 6, 7, 8]. In this framework,1
Comparison of H.323 and SIP for IP telephony signaling

Two standards currently compete for the dominance of IP telephony signaling: the H.323 protocol suite by ITU-T, and the Session Initiation Protocol (SIP) by IETF. Both of these signaling protocols provide mechanisms for call establishment and teardown, call control and supplementary services, and capability exchange. We investigate and compare these two protocols in terms of Functionality, Quality of Service (QoS), Scalability, Flexibility, Interoperability, and Ease of Implementation. For fairness of comparison, we consider similar scenarios for both protocols. In particular, we focus on scenarios that involve a gatekeeper for H.323, and a Proxy/Redirect server for SIP. The reason is that medium-to-large IP Telephony systems are not manageable without a gatekeeper or proxy server. We consider all three versions of H.323. In terms of functionality and services that can be supported, H.323 version 2 and SIP are very similar. However, supplementary services in H.323 are more rigorously defined, and therefore fewer interoperability issues are expected among its implementations. Furthermore, H.323 has taken more steps to ensure compatibility among its different versions, and to interoperate with PSTN. The two protocols are comparable in their QoS support [similar call setup delays, no support for resource reservation or class of service (CoS) setting], but H.323 version 3 will allow signaling of the requested CoS. SIP's primary advantages are (1) flexibility to add new features, and (2) relative ease of implementation and debugging. Finally, we note that H.323 and SIP are improving themselves by learning from each other, and the differences between them are diminishing with each new version.
Ten-year follow-up of the OPUS specialized early intervention trial for patients with a first episode of psychosis.

INTRODUCTION Specialized early intervention programs such as The Danish OPUS treatment are efficient in treating patients with a first episode of psychosis (FEP) at least after 2 and 5 years. Few studies have examined long-term outcomes of these interventions. AIM To examine the effect of 2 years of OPUS vs treatment as usual (TAU) within an FEP cohort, 10 years after inclusion into the OPUS trial. METHODS From 1998 to 2000, participants were randomized to OPUS or TAU. Ten years later, we conducted comprehensive interviews and performed register-based follow-up on all participants in national Danish registers. We analyzed participants according to the intention-to-treat principle. RESULTS Of the 547 participants included in the study, 347 (63.4%) took part in this follow-up. While there was evidence of a differential 10-year course in the development of negative symptoms, psychiatric bed days, and possibly psychotic symptoms in favor of OPUS treatment, differences were driven by effects at earlier follow-ups and had diminished over time. Statistically significant differences in the course of use of supported housing were present even after 8-10 years. There were no differences between OPUS and TAU regarding income, work-related outcomes, or marital status. CONCLUSION Most of the positive short-term effects of the OPUS intervention had diminished or vanished at this long-term follow-up. We observed a clear tendency that OPUS treatment leads to fewer days in supported housing. There is a need for further studies investigating if extending the intervention will improve outcomes more markedly at long-term follow-ups.
A test of the role of polyunsaturated fatty acids in phytoplankton food quality for Daphnia using liposome supplementation

We conducted a series of experiments using the herbivorous zooplankter Daphnia pulex to investigate the nutritional importance of dietary polyunsaturated fatty acids (PUFAs). Daphnia were fed three different diets: (1) a PUFA‐deficient cyanophyte mixture, (2) a cyanophyte mixture with fatty acid (FA) amendments, or (3) a PUFA‐rich cryptophyte mixture. We devised a novel method using customized phosphatidylcholine liposomes to deliver specific FA amendments in a pure and bioavailable form that closely mimics their form in natural diets. We added FA‐impregnated liposomes to the cyanophyte mixtures at levels equivalent to the observed differences in FA concentrations between the cyanophyte and cryptophyte mixtures. Liposome control amendments (without FAs added) had no effect on Daphnia growth. Eicosapentaenoic acid (EPA)‐impregnated liposome amendments accounted for 30% of Daphnia somatic growth‐rate differences and 38% of clutch‐size differences between the cyanophyte and cryptophyte diets. Liposome supplementation of a FA mixture, which included a saturated fatty acid and the four ω3 PUFAs most prevalent in cryptophytes but rare in cyanophytes, accounted for 59% of Daphnia somatic growthrate differences and 47% of clutch‐size differences between the cyanophyte and cryptophyte diets. Our study suggests that phytoplankton ω3 PUFA, and especially EPA, content plays an important direct role in herbivorous zooplankton nutrition.
Cathepsin K knockout alleviates aging-induced cardiac dysfunction

Aging is a major risk factor for cardiovascular disease. It has previously been shown that protein levels of cathepsin K, a lysosomal cysteine protease, are elevated in the failing heart and that genetic ablation of cathepsin K protects against pressure overload‐induced cardiac hypertrophy and contractile dysfunction. Here we test the hypothesis that cathepsin K knockout alleviates age‐dependent decline in cardiac function. Cardiac geometry, contractile function, intracellular Ca2+ properties, and cardiomyocyte apoptosis were evaluated using echocardiography, fura‐2 technique, immunohistochemistry, Western blot and TUNEL staining, respectively. Aged (24‐month‐old) mice exhibited significant cardiac remodeling (enlarged chamber size, wall thickness, myocyte cross‐sectional area, and fibrosis), decreased cardiac contractility, prolonged relengthening along with compromised intracellular Ca2+ release compared to young (6‐month‐old) mice, which were attenuated in the cathepsin K knockout mice. Cellular markers of senescence, including cardiac lipofuscin, p21 and p16, were lower in the aged‐cathepsin K knockout mice compared to their wild‐type counterpart. Mechanistically, cathepsin K knockout mice attenuated an age‐induced increase in cardiomyocyte apoptosis and nuclear translocation of mitochondrial apoptosis‐inducing factor (AIF). In cultured H9c2 cells, doxorubicin stimulated premature senescence and apoptosis. Silencing of cathepsin K blocked the doxorubicin‐induced translocation of AIF from the mitochondria to the nuclei. Collectively, these results suggest that cathepsin K knockout attenuates age‐related decline in cardiac function via suppressing caspase‐dependent and caspase‐independent apoptosis.
Underpricing, Stock Allocation, Ownership Structure and Post-Listing Liquidity of Newly Listed Firms

This study investigates the relationship between underpricing, ownership structure and post-listing liquidity of initial public offerings (IPOs). It is argued that higher underpricing induces both broader investor participation and creates a more diffuse ownership structure. These two factors are in turn positively associated with the level of post-listing trading, and therefore offer an explanation of how underpricing can influence liquidity. Using a sample of Australian IPOs, we provide evidence of statistically significant relationship between underpricing and various proxies for shareholding distribution and liquidity. This result remains robust after controlling for a number of potential underlying factors that may drive both underpricing and ownership allocation decisions. Overall, our analysis suggests that liquidity is a partial but important benefit of underpricing an IPO.
Group Identification Moderates Emotional Responses to Perceived Prejudice

Two studies tested the prediction that group identification (importance of the group in the self-concept) moderates the impact of perceived discrimination on self-evaluative emotions (depression and self-esteem). In Study 1, women low in gender identification experienced less depressed emotion and higher self-esteem if a negative evaluation was due to sexism than when it was not. The self-evaluative emotions of women high in gender identification were not buffered by attributions to sexism. In Study 2, ethnic identification and depressed emotions were positively related when Latino-Americans read about pervasive prejudice against the ingroup but were negatively related when they read about prejudice against an outgroup. Both studies demonstrated that for highly group identified individuals, prejudice against the ingroup is a threat against the self. Thus, the self-protective strategy of attributing negative feedback to discrimination may be primarily effective for individuals who do not consider the group a central aspect of self.
Clinical Course, Radiological Manifestations, and Outcome of Pneumocystis jirovecii Pneumonia in HIV Patients and Renal Transplant Recipients

Background Pneumocystis jirovecii pneumonia (PCP) is a frequent opportunistic infection in immunocompromised patients. In literature, presentation and outcome of PCP differs between patients with human immunodeficiency virus (HIV) infection and renal transplant recipients (RTRs). Methods We conducted a cross-sectional study of patients with PCP based on the HIV and renal transplant registries at our institution. Radiological and clinical data from all confirmed PCP cases between 2005 and 2012 were compared. Results Forty patients were included: 16 with HIV and 24 RTRs. Radiologically, HIV patients had significantly more areas of diffuse lung affection (81% HIV vs. 25% RTR; p = 0.02), more ground glass nodules 5–10 mm (69% vs. 4%; p = <0.001) and enlarged hilar lymph nodes were found only in HIV patients (44%). Cough and dyspnea were the most common clinical signs (>80%) in both groups. Duration from illness onset to hospital presentation was longer in the HIV patients (median of 18 vs. 10 days (p = 0.02)), implying a less fulminant clinical course. Sixty percent of PCP cases in RTRs occurred >12 months after transplantation. Lengths of hospitalization, admission rates to the intensive care unit, and requirements for mechanical ventilation were similar. Outcome in both groups was favourable. Conclusions While important differences in radiological presentation of PCP between HIV patients and RTRs were found, clinical presentation was similar. PCP only rarely presented with fulminant respiratory symptoms requiring ICU admission, with similar results and outcomes for HIV patients and RTRs. Early diagnosis and treatment is mandatory for clinical success.
A holistic tri-region MLC STT-RAM design with combined performance, energy, and reliability optimizations

Multi-level cell spin-transfer torque random access memory (MLC STT-RAM) demonstrates great potentials in onchip cache design for its high storage density and non-volatility but also suffers from the degraded access time, reliability and energy efficiency. The existing MLC STT-RAM cache designs primarily focus on the performance and energy optimizations, however, often ignore the crucial demand for reliability. In this work, we propose a tri-region MLC STT-RAM cache design (TMSC) to simultaneously meet the requirements of performance, energy, and reliability. The tri-region MLC STT-RAM cache is optimized partitioned into fast, mixed, and slow ways according to different access performance, energy and reliability. A new error correction code (ECC) scheme, namely, non-uniform strength ECC (NUS-ECC), is also developed to tolerate the different bit failure rates in these ways. Compared to the latest performance-driven MLC STT-RAM cache design with pessimistic ECC scheme, our TMSC technique can improve the system performance and energy by averagely 9.3% and 9.4%, respectively, for various applications. The additional area cost associated with NUS-ECC is limited by 3.2% compared to the pessimistic ECC scheme.
Endothelium-Dependent Relaxation in Aorta of BB Rat

The study was undertaken to determine whether the phenomenon of endothelium-dependent relaxation was impaired in the spontaneously diabetic BB Wistar rat. Endothelium-dependent relaxation in the aorta of overtly diabetic animals was compared with that in nondiabetic BB rats. The relaxative responses were elicited in vitro to acetylcholine (−8.0 to −5.5 log M) and histamine (−7.0 to −3.0 log M) after precontraction with norepinephrine (−6.0 log M). The maximum relaxations produced by both acetylcholine and histamine expressed as percentages of the contractions to norepinephrine were significantly lower in diabetic than in nondiabetic rats. Scanning electron microscopy revealed that in diabetic BB rats there was consistent evidence of swollen cells, raised nuclei, and sloughing of nuclei in endothelial cells of the aorta. In nondiabetic animals these features were not evident. These findings suggest the presence of a functional and morphological defect in endothelial cells in the aorta of the BB rat.
PhyloBayes MPI: phylogenetic reconstruction with infinite mixtures of profiles in a parallel environment.

Modeling across site variation of the substitution process is increasingly recognized as important for obtaining more accurate phylogenetic reconstructions. Both finite and infinite mixture models have been proposed and have been shown to significantly improve on classical single-matrix models. Compared with their finite counterparts, infinite mixtures have a greater expressivity. However, they are computationally more challenging. This has resulted in practical compromises in the design of infinite mixture models. In particular, a fast but simplified version of a Dirichlet process model over equilibrium frequency profiles implemented in PhyloBayes has often been used in recent phylogenomics studies, while more refined model structures, more realistic and empirically more fit, have been practically out of reach. We introduce a message passing interface version of PhyloBayes, implementing the Dirichlet process mixture models as well as more classical empirical matrices and finite mixtures. The parallelization is made efficient thanks to the combination of two algorithmic strategies: a partial Gibbs sampling update of the tree topology and the use of a truncated stick-breaking representation for the Dirichlet process prior. The implementation shows close to linear gains in computational speed for up to 64 cores, thus allowing faster phylogenetic reconstruction under complex mixture models. PhyloBayes MPI is freely available from our website www.phylobayes. org.
The transfer of content knowledge in a cascade model of professional development

A cascade model of professional development presents a particular risk that ‘knowledge’ promoted in a programme will be diluted or distorted as it passes from originators of the programme to local trainers and then to the target teachers. Careful monitoring of trainers’ and teachers’ knowledge as it is transferred through the system is therefore imperative. This paper focuses on the transfer of content knowledge through an in-service teacher professional development programme and offers an innovative methodology for investigating knowledge transfer, i.e. through insights gained during a mentoring process. The findings suggest that this methodology facilitated assessment of knowledge transfer because it involved the identification of knowledge in practice. The focus on knowledge in practice appeared to avoid a deficit model of trainers’/teachers’ knowledge and revealed that content knowledge was generally being successfully transferred throughout the system. A detailed analysis of different aspects of content knowledge transfer suggested various foci for additional training.
Financial development and economic growth in Malaysia : the stock market perspective

Understanding the causal relationship between financial development and economic growth is important in enhancing the economy of a nation. Using the autoregressive distributed lag (ARDL) bounds test approach, this study finds that stock market development is cointegrated with economic growth in the context of Malaysia. Moreover, this test also suggests that stock market development has a significant positive long-run impact on economic growth. Granger-causality test based on vector error correction model (VECM) further reveals that stock market development Granger-causes economic growth. Hence, this study provides robust empirical evidence in favor of finance-led growth hypothesis for the Malaysian economy.
Safety and Efficacy of Omarigliptin (MK-3102), a Novel Once-Weekly DPP-4 Inhibitor for the Treatment of Patients With Type 2 Diabetes

OBJECTIVE This study was conducted to determine the optimal dose of omarigliptin, a once-weekly (q.w.) dipeptidyl peptidase IV (DPP-4) inhibitor, for the treatment of patients with type 2 diabetes and evaluate the long-term safety of that dose. RESEARCH DESIGN AND METHODS In a multicenter, double-blind, 12-week, dose-range finding study, 685 oral antihyperglycemic agent-naïve or washed-out subjects with type 2 diabetes were randomized to one of five once-weekly doses of omarigliptin (0.25 mg, 1 mg, 3 mg, 10 mg, or 25 mg) or placebo. The primary efficacy end point was change from baseline in HbA1c, and secondary end points were 2-h postmeal glucose (PMG) and fasting plasma glucose (FPG). Analysis included all patients who received at least one dose of the study medication. Subjects who completed the base study were eligible to enter a 66-week extension study. RESULTS Once-weekly treatment for 12 weeks with omarigliptin provided dose-related reductions in HbA1c, 2-h PMG, and FPG. At week 12, the omarigliptin 25-mg dose provided the greatest glycemic efficacy. The placebo-adjusted least-squares mean reductions from baseline in HbA1c, 2-h PMG, and FPG were −0.72% (−7.8 mmol/mol), −2.5, and −1.3 mmol/L, respectively (all P < 0.001). The incidence of adverse events was similar across dose groups, with a low incidence of symptomatic hypoglycemia and no effect on body weight. Omarigliptin was generally well-tolerated throughout the base and extension studies. CONCLUSIONS Omarigliptin 25 mg q.w. , compared with placebo, provided significant glucose lowering and was generally well tolerated for up to 78 weeks in patients with type 2 diabetes.
The pursuit of citizens' privacy: a privacy-aware smart city is possible

Cities are growing steadily, and the process of urbanization is a common trend in the world. Although cities are getting bigger, they are not necessarily getting better. With the aim to provide citizens with a better place to live, a new concept of a city was born: the smart city. The real meaning of smart city is not strictly defined, but it has gained much attention, and many cities are taking action in order to be considered 'smart'. These smart cities, founded on the use of information and communication technologies, aim at tackling many local problems, from local economy and transportation to quality of life and e-governance. Although technology helps to solve many of these local problems, their ability to gather unprecedented amounts of information could endanger the privacy of citizens. In this article we identify a number of privacy breaches that can appear within the context of smart cities and their services. We leverage some concepts of previously defined privacy models and define the concept of citizens' privacy as a model with five dimensions: identity privacy, query privacy, location privacy, footprint privacy and owner privacy. By means of several examples of smart city services, we define each privacy dimension and show how existing privacy enhancing technologies could be used to preserve citizens' privacy.
Role of the PLDLS-Binding Cleft Region of CtBP1 in Recruitment of Core and Auxiliary Components of the Corepressor Complex

ABSTRACT C-terminal binding protein (CtBP) family proteins CtBP1 and CtBP2 are highly homologous transcriptional corepressors and are recruited by a large number of transcription factors to mediate sequence-specific transcriptional repression. In addition to DNA-binding repressors, the nuclear protein complex of CtBP1 consists of enzymatic constituents such as histone deacetylases (HDAC1/2), histone methyl transferases (HMTases; G9a and GLP), and the lysine-specific demethylase (LSD1). Additionally, CtBPs also recruit the components of the sumoylation machinery. The CtBPs contain two different unique structural elements, a hydrophobic cleft, with which factors that contain motifs related to the E1A PLDLS motif bind, and a surface groove that binds with factors containing motifs related to the sequence RRTGXPPXL (RRT motif). By structure-based functional dissection of CtBP1, we show that the PLDLS-binding cleft region functions as the primary recruitment center for DNA-binding factors and for the core and auxiliary enzymatic constituents of the CtBP1 corepressor complex. We identify HDAC1/2, CoREST/LSD1, and Ubc9 (E2) as the core constituents of the CtBP1 complex, and these components interact with the PLDLS cleft region through non-PLDLS interactions. Among the CtBP core constituents, HDACs contribute predominantly to the repression activity of CtBP1. The auxiliary components include an HMTase complex (G9a/Wiz/CDYL) and two SUMO E3 ligases, HPC2 and PIAS1. The interaction of auxiliary components with CtBP1 is excluded by PLDLS (E1A)-mediated interactions. Although monomeric CtBP1 is proficient in the recruiting of both core and auxiliary components, NAD(H)-dependent dimerization is required for transcriptional repression. We also provide evidence that CtBP1 functions as a platform for sumoylation of cofactors.