Miracle-dz/UniFAR-FTUs huggingface dataset:
Effective Slot Filling Based on Shallow Distant Supervision Methods

Spoken Language Systems at Saarland University (LSV) participated this year with 5 runs at the TAC KBP English slot filling track. Effective algorithms for all parts of the pipeline, from document retrieval to relation prediction and response post-processing, are bundled in a modular end-to-end relation extraction system called RelationFactory. The main run solely focuses on shallow techniques and achieved significant improvements over LSV's last year's system, while using the same training data and patterns. Improvements mainly have been obtained by a feature representation focusing on surface skip n-grams and improved scoring for extracted distant supervision patterns. Important factors for effective extraction are the training and tuning scheme for distant supervision classifiers, and the query expansion by a translation model based on Wikipedia links. In the TAC KBP 2013 English Slotfilling evaluation, the submitted main run of the LSV RelationFactory system achieved the top-ranked F1-score of 37.3%.
A phase noise mitigation scheme for MIMO WLANs with spatially correlated and imperfectly estimated channels

Applying multiple input multiple output (MIMO) technique to OFDM-based wireless local area networks (WLANs) promises impressive high capacity and spectral efficiency compared with conventional systems. However, similar to SISO-OFDM, MIMO-OFDM suffers significant performance degradation due to the presence of phase noise. Many methods have been developed to mitigate phase noise for a single antenna system with perfect channel estimation, whereas none has been proposed for correlated MIMO-OFDM scenarios. Therefore, in this letter, by using the phase noise correlation function, a new phase noise mitigation scheme is proposed for the general M/sub T//spl times/M/sub R/ MIMO WLANs system with channel estimation errors. Numerical results show that, compared with conventional approaches, the proposed scheme achieves significant performance gain with high spectral efficiency, requiring few pilots, and is robust to spatial correlation and channel estimation errors, which makes it very attractive for practical applications.
Burst dynamics during drainage displacements in porous media: Simulations and experiments

We investigate the burst dynamics during drainage going from low to high injection rate at various fluid viscosities. The bursts are identified as pressure drops in the pressure signal across the system. We find that the statistical distribution of pressure drops scales according to other systems exhibiting self-organized criticality. The pressure signal was calculated by a network model that properly simulates drainage displacements. We compare our results with corresponding experiments.
Transcriptional Control of Vascular Smooth Muscle Cell Proliferation by Peroxisome Proliferator-Activated Receptor-γ: Therapeutic Implications for Cardiovascular Diseases

Proliferation of vascular smooth muscle cells (SMCs) is a critical process for the development of atherosclerosis and complications of procedures used to treat atherosclerotic diseases, including postangioplasty restenosis, vein graft failure, and transplant vasculopathy. Peroxisome proliferator-activated receptor (PPAR) γ is a member of the nuclear hormone receptor superfamily and the molecular target for the thiazolidinediones (TZD), used clinically to treat insulin resistance in patients with type 2 diabetes. In addition to their efficacy to improve insulin sensitivity, TZD exert a broad spectrum of pleiotropic beneficial effects on vascular gene expression programs. In SMCs, PPARγ is prominently upregulated during neointima formation and suppresses the proliferative response to injury of the arterial wall. Among the molecular target genes regulated by PPARγ in SMCs are genes encoding proteins involved in the regulation of cell-cycle progression, cellular senescence, and apoptosis. This inhibition of SMC proliferation is likely to contribute to the prevention of atherosclerosis and postangioplasty restenosis observed in animal models and proof-of-concept clinical studies. This review will summarize the transcriptional target genes regulated by PPARγ in SMCs and outline the therapeutic implications of PPARγ activation for the treatment and prevention of atherosclerosis and its complications.
Specificity of the VP1 GH Loop of Foot-and-Mouth Disease Virus for αv Integrins

ABSTRACT Foot-and-mouth disease virus (FMDV) can use a number of integrins as receptors to initiate infection. Attachment to the integrin is mediated by a highly conserved arginine-glycine-aspartic acid (RGD) tripeptide located on the GH loop of VP1. Other residues of this loop are also conserved and may contribute to integrin binding. In this study we have used a 17-mer peptide, whose sequence corresponds to the GH loop of VP1 of type O FMDV, as a competitor of integrin-mediated virus binding and infection. Alanine substitution through this peptide identified the leucines at the first and fourth positions following RGD (RGD+1 and RGD+4 sites) as key for inhibition of virus binding and infection mediated by αvβ6 or αvβ8 but not for inhibition of virus binding to αvβ3. We also show that FMDV peptides containing either methionine or arginine at the RGD+1 site, which reflects the natural sequence variation seen across the FMDV serotypes, are effective inhibitors for αvβ6. In contrast, although RGDM-containing peptides were effective for αvβ8, RGDR-containing peptides were not. These observations were confirmed by showing that a virus containing an RGDR motif uses αvβ8 less efficiently than αvβ6 as a receptor for infection. Finally, evidence is presented that shows αvβ3 to be a poor receptor for infection by type O FMDV. Taken together, our data suggest that the integrin binding loop of FMDV has most likely evolved for binding to αvβ6 with a higher affinity than to αvβ3 and αvβ8.
The plasmamembrane calmodulin–dependent calcium pump

The plasma membrane calcium/calmodulin-dependent calcium ATPase (PMCA) (Shull, G.E., and J. Greeb. 1988. J. Biol. Chem. 263:8646–8657; Verma, A.K., A.G. Filoteo, D.R. Stanford, E.D. Wieben, J.T. Penniston, E.E. Strehler, R. Fischer, R. Heim, G. Vogel, S. Mathews, et al. 1988. J. Biol. Chem. 263:14152–14159; Carafoli, E. 1997. Basic Res. Cardiol. 92:59–61) has been proposed to be a regulator of calcium homeostasis and signal transduction networks of the cell. However, little is known about its precise mechanisms of action. Knock-out of (mainly neuronal) isoform 2 of the enzyme resulted in hearing loss and balance deficits due to severe inner ear defects, affecting formation and maintenance of otoconia (Kozel, P.J., R.A. Friedman, L.C. Erway, E.N. Yamoah, L.H. Liu, T. Riddle, J.J. Duffy, T. Doetschman, M.L. Miller, E.L. Cardell, and G.E. Shull. 1998. J. Biol. Chem. 273:18693–18696). Here we demonstrate that PMCA 4b is a negative regulator of nitric oxide synthase I (NOS-I, nNOS) in HEK293 embryonic kidney and neuro-2a neuroblastoma cell models. Binding of PMCA 4b to NOS-I was mediated by interaction of the COOH-terminal amino acids of PMCA 4b and the PDZ domain of NOS-I (PDZ: PSD 95/Dlg/ZO-1 protein domain). Increasing expression of wild-type PMCA 4b (but not PMCA mutants unable to bind PDZ domains or devoid of Ca2+-transporting activity) dramatically downregulated NO synthesis from wild-type NOS-I. A NOS-I mutant lacking the PDZ domain was not regulated by PMCA, demonstrating the specific nature of the PMCA–NOS-I interaction. Elucidation of PMCA as an interaction partner and major regulator of NOS-I provides evidence for a new dimension of integration between calcium and NO signaling pathways.
Of Mental States and Machine Learning

Using research in social cognition as a foundation, we studied rapid versus reflective mental state attributions and the degree to which machine learning classifiers can be trained to make such judgments. We observed differences in response times between conditions, but did not find significant differences in the accuracy of mental state attributions. We additionally demonstrate how to train machine classifiers to identify mental states. We discuss advantages of using an interdisciplinary approach to understand and improve human-robot interaction and to further the development of social cognition in artificial intelligence.
Ranking Intervals and Dominance Relations for Ratio-Based Efficiency Analysis

We develop comparative results for ratio-based efficiency analysis (REA) based on the decision-making units' (DMUs') relative efficiencies over sets of feasible weights that characterize preferences for input and output variables. Specifically, we determine (i) ranking intervals, which indicate the best and worst efficiency rankings that a DMU can attain relative to other DMUs; (ii) dominance relations, which show what other DMUs a given DMU dominates in pairwise efficiency comparisons; and (iii) efficiency bounds, which show how much more efficient a given DMU can be relative to some other DMU or a subset of other DMUs. Unlike conventional efficiency scores, these results are insensitive to outlier DMUs. They also show how the DMUs' efficiency ratios relate to each other for all feasible weights, rather than for those weights only for which the data envelopment analysis (DEA) efficiency score of some DMU is maximized. We illustrate the usefulness of these results by revisiting reported DEA studies and by describing a recent case study on the efficiency comparison of university departments. This paper was accepted by Teck-Hua Ho, decision analysis.
Generating knowledge in a Learning Study – from the perspective of a teacher researcher

Abstract The purpose of this article is to discuss and describe how a clinical research method can be used to generate knowledge about teaching and learning. This will be addressed from a teacher researcher’s perspective, taking a conducted Learning Study as the departure. Learning Study is an interventionist, iterative and collaborative research approach, focusing on the teaching of an object of learning. The actual study was conducted by a teacher researcher leading a teacher research team in a study about story-writing in primary school. The research process and the results are discussed using four areas that are described as dichotomies by Labaree (Labaree, D.F. 2003. “The Peculiar Problems of Preparing Educational Researchers.” Educational Researcher 32 (4): 13–22). Labaree states that teacher researchers need to go from being normative, experimental, personal and particular to being analytical, theoretical, intellectual and universal. By using examples from the Learning Study, I argue that these areas do not have to be seen as dichotomies; instead they can be combined and intertwined. Thus, in a Learning Study, elements from both the teaching practice and the academic practice matter, thus enhancing the possibility that results are useful for practitioners.
Attitudes of Students Taking Distance Education in Theology Undergraduate Education Program Towards E-Learning Management System.

Education is one of the biggest problems experienced by developing societies. Education is has an important place in individuals’ lives since it allows them to prove themselves within their society and to maintain their future lives. Today, with the development of the Internet, education can be given via e-learning management systems designed on the web. E-learning is a type of education that can present information to its users via the Internet. In order to facilitate the use of e-learning systems and to make these systems more systematic, Learning Management Systems (LMSs) have appeared. LMSs are softwares that allow management of learning activities. During the application of e-learning management systems that can be designed in line with the desired curriculum, the feedback provided by students taking education via this platform play an important role in the success of the system. In this respect, the present study aimed at determining the attitudes of students attending Distance Education Theology Undergraduate Education Program at Dicle University towards e-learning. For this purpose, the five-point Likert-type scale of “Attitudes towards ICT skills and e-learning” developed by Haznedar [23] was applied to the students. The results of analysis of the data collected from the students participating in the study revealed no significant difference in relation to e-learning between the students’ gender, years of computer use, weekly Internet use time, their preferences of types of education, their foreign language, their foreign language proficiency levels, and their learning motivation preferences. In the study, a significant difference was found in relation to e-learning between the participants’ preferences of study methods.
Sucrose synthase isozyme SUS1 in the maize root cap is preferentially localized in the endopolyploid outer cells

The structure of the maize (Zea mays L.) root cap was studied to quantitatively evaluate the relationship among the size of the cells, their endopolyploidy level, and the abundance of the sucrose synthase isozyme SUS1. Median longitudinal root cap sections were analysed using immunolocalization, quantitative DNA staining, and image cytometry. Both the immunolocalization signal for the SUS1 protein and the endopolyploidy level increased from calyptrogen towards the root cap periphery and were thus the highest in the outer cells. These cells had a nuclear DNA content of mostly 8C or higher and the largest volumes of all root cap cells. The high amount of SUS1 protein in the outer, endopolyploid cells suggests an association between endoreduplication and the abundance of this enzyme. The outer cells are involved in mucilage production; hence, there is a possibility that sucrose synthase provides monosaccharide precursors for mucilage synthesis.Key words: nuclear DNA amount, endoreduplication, immunolocalizat.
Subgroups of direct products closely approximated by direct sums

Let $I$ be an infinite set, $\{G_i:i\in I\}$ be a family of (topological) groups and $G=\prod_{i\in I} G_i$ be its direct product. For $J\subseteq I$, $p_{J}: G\to \prod_{j\in J} G_j$ denotes the projection. We say that a subgroup $H$ of $G$ is: (i) \emph{uniformly controllable} in $G$ provided that for every finite set $J\subseteq I$ there exists a finite set $K\subseteq I$ such that $p_{J}(H)=p_{J}(H\cap\bigoplus_{i\in K} G_i)$; (ii) \emph{controllable} in $G$ provided that $p_{J}(H)=p_{J}(H\cap\bigoplus_{i\in I} G_i)$ for every finite set $J\subseteq I$; (iii) \emph{weakly controllable} in $G$ if $H\cap \bigoplus_{i\in I} G_i$ is dense in $H$, when $G$ is equipped with the Tychonoff product topology. One easily proves that (i)$\to$(ii)$\to$(iii). We thoroughly investigate the question as to when these two arrows can be reversed. We prove that the first arrow can be reversed when $H$ is compact, but the second arrow cannot be reversed even when $H$ is compact. Both arrows can be reversed if all groups $G_i$ are finite. When $G_i=A$ for all $i\in I$, where $A$ is an abelian group, we show that the first arrow can be reversed for {\em all} subgroups $H$ of $G$ if and only if $A$ is finitely generated. Connections with coding theory are highlighted.
Depression Symptoms and Marital Quality in Vietnam-Era Veterans: Does the Presence of Higher Post-Traumatic Stress Symptoms (PTSS) Matter?

Depression Symptoms and Marital Quality in Vietnam-Era Veterans: Does the Presence of Higher Post-Traumatic Stress Symptoms (PTSS) Matter? Kevin L. Stott School of Family Life, BYU Master of Science Using data from 617 Vietnam-era veterans, this study aimed to better understand the relationships between depression symptoms, post-traumatic stress symptoms, and overall marital quality. Results indicated that depression symptoms and PTSS each had a negative relationship with marital quality when considered individually. The association between depression symptoms and marital quality persisted when PTSS was accounted for. However, the significant association between PTSS and marital quality dropped out. Further, PTSS did not moderate the association between depression symptoms and marital quality. The current study suggests that depression symptoms and PTSS overlap in relation to marital quality among Vietnam-era veterans, with depression symptoms playing a major role. Future research should address samples across various age groups, different war campaigns, and among veterans with higher levels of clinical distress.
An Optimal Global Nearest Neighbor Metric

A quadratic metric dAO (X, Y) =[(X - Y)T AO(X - Y)]¿ is proposed which minimizes the mean-squared error between the nearest neighbor asymptotic risk and the finite sample risk. Under linearity assumptions, a heuristic argument is given which indicates that this metric produces lower mean-squared error than the Euclidean metric. A nonparametric estimate of Ao is developed. If samples appear to come from a Gaussian mixture, an alternative, parametrically directed distance measure is suggested for nearness decisions within a limited region of space. Examples of some two-class Gaussian mixture distributions are included.
The impact of cirrhosis on CD4+ T cell counts in HIV-seronegative patients.

BACKGROUND Studies of the progression liver fibrosis in human immunodeficiency virus (HIV) and hepatitis C virus-coinfected patients suggest that cirrhosis is associated with immunosuppression, as measured by low absolute CD4(+) T cell counts. However, we hypothesized that, in patients with advanced liver disease, low CD4(+) T cell counts may occur secondary to portal hypertension and splenic sequestration, regardless of the presence or absence of HIV infection. METHODS Sixty HIV-seronegative outpatients with cirrhosis were enrolled during the period 2001-2003 in a prospective, cross-sectional study of the association between liver disease and CD4(+) T cell counts and percentages. Demographic characteristics, liver disease-related characteristics, and laboratory results--including CD4(+) T cell parameters--were collected. RESULTS A total of 39 patients (65%) had a low CD4(+) T cell count; 26 patients (43%) and 4 patients (7%) had CD4(+) T cell counts <350 and <200 cells/mm(3), respectively. Abnormal CD4(+) T cell counts were associated with splenomegaly (P=.03), thrombocytopenia (P=.002), and leukopenia (P<.001). The percentage of CD4(+) T cells was normal in 95% of patients who had a low absolute CD4(+) T cell count. CD4(+) T cell counts were significantly lower among cirrhotic patients than among 7638 HIV-seronegative historic control subjects without liver disease. CONCLUSIONS Cirrhosis is associated with low CD4(+) T cell counts in the absence of HIV infection. Discordance between low absolute CD4(+) T cell counts and normal CD4(+) T cell percentages may be attributable to portal hypertension and splenic sequestration. Our findings have significant implications for the use and interpretation of absolute CD4(+) T cell counts in HIV-infected patients with advanced liver disease.
Optimal Placement of Accelerometers for the Detection of Everyday Activities

This article describes an investigation to determine the optimal placement of accelerometers for the purpose of detecting a range of everyday activities. The paper investigates the effect of combining data from accelerometers placed at various bodily locations on the accuracy of activity detection. Eight healthy males participated within the study. Data were collected from six wireless tri-axial accelerometers placed at the chest, wrist, lower back, hip, thigh and foot. Activities included walking, running on a motorized treadmill, sitting, lying, standing and walking up and down stairs. The Support Vector Machine provided the most accurate detection of activities of all the machine learning algorithms investigated. Although data from all locations provided similar levels of accuracy, the hip was the best single location to record data for activity detection using a Support Vector Machine, providing small but significantly better accuracy than the other investigated locations. Increasing the number of sensing locations from one to two or more statistically increased the accuracy of classification. There was no significant difference in accuracy when using two or more sensors. It was noted, however, that the difference in activity detection using single or multiple accelerometers may be more pronounced when trying to detect finer grain activities. Future work shall therefore investigate the effects of accelerometer placement on a larger range of these activities.
Lipids in Health and Disease

Background: In man, elevated levels of plasma plipoprotein (a)(Lp(a)) is a cardiovascular risk factor, and oxidized phospholipids are believed to play a role as modulators of inflammatory processes such as atherosclerosis. Polyamines are potent antioxidants and anti-inflammatory agents. It was therefore of interest to examine polyamines and their metabolism in LPA transgenic mice. Concentration of the polyamines putrescine, spermidine and spermine as well as the activity of peroxisomal polyamine oxidase and two other peroxisomal enzymes, acyl-CoA oxidase and catalase were measured. The mice were fed either a standard diet or a diet high in fat and cholesterol (HFHC). Some of the mice in each feeding group were in addition given aminoguanidine (AG), a specific inhibitor of diamine oxidase, which catalyses degradation of putrescine, and also inhibits non-enzymatic glycosylation of protein which is implicated in the aetiology of atherosclerosis in diabetic patients. Non-transgenic mice were used as controls. Results: Intestinal peroxisomal polyamine oxidase activity was significantly higher in LPA transgenic mice than in the non-transgenic mice, while intestinal peroxisomal catalase activity was significantly lower. Hepatic β-oxidation increased in Lp(a) transgenic mice fed the HFHC diet, but not in those on standard diet. Hepatic spermidine concentration was increased in all mice fed the HFHC diet compared to those fed a standard diet, while spermine concentration was decreased. With exception of the group fed only standard diet, transgenic mice showed a lower degree of hepatic steatosis than non-transgenic mice. AG had no significant effect on hepatic steatosis. Conclusion: The present results indicate a connection between peroxisomal enzyme activity and the presence of the human LPA gene in the murine genome. The effect may be a result of changes in oxidative processes in lipid metabolism rather than resulting from a direct effect of the LPA construct on the peroximal gene expression. Published: 04 October 2005 Lipids in Health and Disease 2005, 4:23 doi:10.1186/1476-511X-4-23 Received: 10 August 2005 Accepted: 04 October 2005 This article is available from: http://www.lipidworld. com/content/4/1/23 © 2005 Eliassen et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.