Miracle-dz/UniFAR-FTUs huggingface dataset:
Early childcare and physical aggression: differentiating social selection and social causation.

BACKGROUND Some research findings have suggested that group day-care may be associated with an increased risk for physical aggression. METHODS Cross-sectional maternal questionnaire data from a representative sample of 3431 Canadian 2- to 3-year-olds were used to compare rates of physical aggression shown by children looked after by their own mothers and those attending group day-care. A family risk index (using occupational level, maternal education, size of sibship, and family functioning) was created to test whether any difference in physical aggression might reflect social selection rather than social causation. RESULTS Aggression was significantly more common in children looked after by their own mothers than in those attending group day-care. Strong social selection associated with family risk was found, not only in the sample as a whole, but even within the high-risk subsample. However, after taking social selection into account, physical aggression was significantly more common in children from high-risk families looked after by their own parents. No such difference was evident in the majority (84%) of children from low-risk families. CONCLUSION Insofar as there are any risks for physical aggression associated with homecare they apply only to high-risk families.
Human Deciduous Teeth Stem Cells (SHED) Display Neural Crest Signature Characters

Human dental tissues are sources of neural crest origin multipotent stem cells whose regenerative potential is a focus of extensive studies. Rational programming of clinical applications requires a more detailed knowledge of the characters inherited from neural crest. Investigation of neural crest cells generated from human pluripotent stem cells provided opportunity for their comparison with the postnatal dental cells. The purpose of this study was to investigate the role of the culture conditions in the expression by dental cells of neural crest characters. The results of the study demonstrate that specific neural crest cells requirements, serum-free, active WNT signaling and inactive SMAD 2/3, are needed for the activity of the neural crest characters in dental cells. Specifically, the decreasing concentration of fetal bovine serum (FBS) from regularly used for dental cells 10% to 2% and below, or using serum-free medium, led to emergence of a subset of epithelial-like cells expressing the two key neural crest markers, p75 and HNK-1. Further, the serum-free medium supplemented with neural crest signaling requirements (WNT inducer BIO and TGF-β inhibitor REPSOX), induced epithelial-like phenotype, upregulated the p75, Sox10 and E-Cadherin and downregulated the mesenchymal genes (SNAIL1, ZEB1, TWIST). An expansion medium containing 2% FBS allowed to obtain an epithelial/mesenchymal SHED population showing high proliferation, clonogenic, multi-lineage differentiation capacities. Future experiments will be required to determine the effects of these features on regenerative potential of this novel SHED population.
Secretome derived from breast tumor cell lines alters the morphology of human umbilical vein endothelial cells

Abstract Metastases, responsible for most of the solid tumor associated deaths, require angiogenesis and changes in endothelial cells. In this work, the effect of the secretomes of three breast tumor cell lines (MCF-7, MDA-MB-231 and ZR-75-30) on human umbilical vein endothelial cells (HUVEC) morphology was investigated. HUVEC treated with secretomes from breast cells were analyzed by confocal and time-lapse microscopy. Secretomes from ZR-75-30 and MDA-MB-231 cells modify the morphology and adhesion of HUVEC. These changes may provoke the loss of endothelial monolayer integrity. In consequence, tumor cells could have an increased access to circulation, which would then enhance metastasis.
Ship Detection From Optical Satellite Images Based on Sea Surface Analysis

Automatic ship detection in high-resolution optical satellite images with various sea surfaces is a challenging task. In this letter, we propose a novel detection method based on sea surface analysis to solve this problem. The proposed method first analyzes whether the sea surface is homogeneous or not by using two new features. Then, a novel linear function combining pixel and region characteristics is employed to select ship candidates. Finally, Compactness and Length-width ratio are adopted to remove false alarms. Specifically, based on the sea surface analysis, the proposed method cannot only efficiently block out no-candidate regions to reduce computational time, but also automatically assign weights for candidate selection function to optimize the detection performance. Experimental results on real panchromatic satellite images demonstrate the detection accuracy and computational efficiency of the proposed method.
Non-specific Defensive Factors of the Pacific Oyster Crassostrea gigas against Infection with Marteilioides chungmuensis: A Flow-Cytometric Study

In order to assess changes in the activity of immunecompetency present in Crassostrea gigas infected with Marteilioides chungmuensis (Protozoa), the total hemocyte counts (THC), hemocyte populations, hemocyte viability, and phagocytosis rate were measured in oysters using flow cytometry. THC were increased significantly in oysters infected with M. chungmuensis relative to the healthy appearing oysters (HAO) (P<0.05). Among the total hemocyte composition, granulocyte levels were significantly increased in infected oysters as compared with HAO (P<0.05). In addition, the hyalinocyte was reduced significantly (P<0.05). The hemocyte viability did not differ between infected oysters and HAO. However, the phagocytosis rate was significantly higher in infected oysters relative to HAO (P<0.05). The measurement of alterations in the activity of immunecompetency in oysters, which was conducted via flow cytometry in this study, might be a useful biomarker of the defense system for evaluating the effects of ovarian parasites of C. gigas.
Chloroplast DNA Structural Variation, Phylogeny, and Age of Divergence among Diploid Cotton Species

The cotton genus (Gossypium spp.) contains 8 monophyletic diploid genome groups (A, B, C, D, E, F, G, K) and a single allotetraploid clade (AD). To gain insight into the phylogeny of Gossypium and molecular evolution of the chloroplast genome in this group, we performed a comparative analysis of 19 Gossypium chloroplast genomes, six reported here for the first time. Nucleotide distance in non-coding regions was about three times that of coding regions. As expected, distances were smaller within than among genome groups. Phylogenetic topologies based on nucleotide and indel data support for the resolution of the 8 genome groups into 6 clades. Phylogenetic analysis of indel distribution among the 19 genomes demonstrates contrasting evolutionary dynamics in different clades, with a parallel genome downsizing in two genome groups and a biased accumulation of insertions in the clade containing the cultivated cottons leading to large (for Gossypium) chloroplast genomes. Divergence time estimates derived from the cpDNA sequence suggest that the major diploid clades had diverged approximately 10 to 11 million years ago. The complete nucleotide sequences of 6 cpDNA genomes are provided, offering a resource for cytonuclear studies in Gossypium.
Ultrasound Speckle Suppression and Edge Enhancement Using Multiscale Nonlinear Wavelet Diffusion

This paper introduces a novel multiscale nonlinear wavelet diffusion (MNWD) method for ultrasound speckle suppression and edge enhancement. It considers wavelet diffusion as an approximation to nonlinear diffusion within the framework of the dyadic wavelet transform. Consequently, this knowledge is exploited in the design of a speckle suppression filter with an edge enhancement feature. MNWD takes advantage of the sparsity and multiresolution properties of wavelet, and the iterative edge enhancement feature of nonlinear diffusion. In our algorithm, speckle is suppressed by employing the iterative multiscale diffusion on the wavelet coefficients, while the edges of the image are enhanced by using an iterative signal compensation process. We validate the proposed method using synthetic and real echocardiographic images. Performance improvement over other traditional denoising filters is quantified in terms of noise suppression and structural preservation indices. The application of the proposed method is demonstrated by the segmentation of the echocardiographic image using the active contour
Depression and social stress among patients with benign breast disease

One hundred and forty women referred to the Southampton breast clinic had a psychiatric interview at home, before their first clinic attendance. The 107 subsequently diagnosed as having benign breast disease had a high rate of depressive symptomatology in comparison with women in published surveys of the general population. In the year before referral, 25 (23 per cent) had had definite depression and 19 (18 per cent) had had borderline depression: at the time of interview 9 (8 per cent) had major depression and 22 (21 per cent) had minor depression. Depression in these patients was associated with recent life events and social difficulties. Mood disturbance and psychosocial stress may lead to medical consultation about benign breast disease, or even contribute to its development. Severe depression was less common in the 33 patients who turned out to have breast cancer, though more of them had minor depression, and they reported fewer recent life events.
The Cuffless Arterial Blood Pressure Estimation based on the Timing- Characteristics of Second Heart Sound

Continuous and non-invasive monitoring of blood pressure (BP) is important to prevent hypertensive patients from stroke and heart attack. However, most of the prevalent BP devices can provide solely intermittent measurements. In this study, a novel parameter RS2 , defined as the time interval from the R wave of electrocardiographic (ECG) signal to the peak of second heart sound of phonocardiographic (PCG) signal, was used for BP estimation. Experiment was conducted on 66 normal and 19 abnormal subjects during resting condition. The results of this study showed that estimation error of systolic BP (SBP) and diastolic BP (DBP) was 2.0plusmn7. 5 mmHg and 0.9plusmn5. 1 mmHg respectively. 94.7% of the difference between measured and estimated SBPs was within plusmn2 standard deviations in the Bland Altman plot. 93.4% of the difference between measured and estimated DBFs was within plusmn2 standard deviations in the Bland Altman plot. The preliminary results illustrated that the RS2 is a promising parameter for continuous and non-invasive estimation of BP in homecare and mobile healthcare
An immunoradiometric assay for ferritin in the serum of normal subjects and patients with iron deficiency and iron overload

An immunoradiometric assay for human ferritin has been developed. Concentrations of ferritin in the serum of male and female controls and patients with iron deficiency and iron overload were measured. Male controls were found to have a significantly higher mean concentration of serum ferritin than females. Patients with iron deficiency had significantly lower levels than normals of either sex and patients with iron overload had greatly elevated serum ferritin concentrations. It is thought that the serum ferritin concentration may reflect the iron stores of the body.
Online Learning with Costly Features and Labels

This paper introduces the online probing problem: In each round, the learner is able to purchase the values of a subset of feature values. After the learner uses this information to come up with a prediction for the given round, he then has the option of paying to see the loss function that he is evaluated against. Either way, the learner pays for both the errors of his predictions and also whatever he chooses to observe, including the cost of observing the loss function for the given round and the cost of the observed features. We consider two variations of this problem, depending on whether the learner can observe the label for free or not. We provide algorithms and upper and lower bounds on the regret for both variants. We show that a positive cost for observing the label significantly increases the regret of the problem.
Comparison of the pattern of atrophy of the corpus callosum in frontotemporal dementia, progressive supranuclear palsy, and Alzheimer's disease

OBJECTIVES The loss of the neurons in layer 3, one of the groups of cortical neurons most vulnerable in various degenerative brain diseases, results in axonal degeneration leading to atrophy of the corpus callosum. Previous studies showed callosal atrophy in three degenerative dementias: frontotemporal dementia (FTD), progressive supranuclear palsy (PSP), and Alzheimer's disease (AD). However, it is unclear whether a characteristic pattern of atrophy is present in each. The objective of this study was to investigate whether the pattern of the callosal atrophy was different among patients with FTD, PSP, or early onset AD. METHODS Eleven patients with FTD, nine patients with PSP, 16 patients with early onset AD, and 23 normal controls, all age and sex matched, were studied using MRI. The ratios of midsagittal corpus callosum areas to the midline internal skull surface area on T1 weighted images were analyzed. The corpus callosum was divided into quarters: the anterior, middle-anterior, middle-posterior, and posterior portions. RESULTS Compared with controls, all three patient groups had significantly decreased total callosal/skull area ratio. An analysis of covariance adjusted for the total callosal area/skull area ratio showed that the anterior quarter callosal/skull area ratio in FTD, the middle-anterior quarter area ratio in PSP, and the posterior quarter area ratio in AD were significantly smaller than those in the other three groups. CONCLUSION Although atrophy of the corpus callosum is not specific to any degenerative dementia, the patterns of the atrophy are different among patients with FTD, PSP, or early onset AD. Differential patterns of callosal atrophy might reflect characteristic patterns of neocortical involvement in each degenerative dementia.
Genetic diversity and population structure of yellow catfish Pelteobagrus fulvidraco from five lakes in the middle and lower reaches of the Yangtze River, China, based on mitochondrial DNA control region

Genetic diversity and population structure of yellow catfish Pelteobagrus fulvidraco were examined by using mitochondrial DNA control region sequences in 143 specimens sampled from five lakes in the middle and lower reaches of the Yangtze River, China; 151 polymorphic sites defined 72 distinct haplotypes. Haplotype diversity indices (0.903–0.953) and nucleotide diversity indices (0.00378–0.00970) demonstrated low genetic diversity of the yellow catfish populations in the five lakes. The analysis of molecular variance and the fixation index ( = 0.0896) revealed insignificant genetic difference between samples from different lakes. In addition, neutral tests and analysis of mismatch distribution suggested that yellow catfish might have undergone a population expansion. Neighbor-joining tree indicated a correlation between these population genetic differences and geographic distance. This study revealed the extant population genetic diversity and structure of the yellow catfish and was in favor of the related fishery management issues including fishery stock identification, conservation, and artificial breeding.
Rv2686c-Rv2687c-Rv2688c, an ABC Fluoroquinolone Efflux Pump in Mycobacterium tuberculosis

ABSTRACT The Mycobacterium tuberculosis Rv2686c-Rv2687c-Rv2688c operon, encoding an ABC transporter, conferred resistance to ciprofloxacin and, to a lesser extent, norfloxacin, moxifloxacin, and sparfloxacin to Mycobacterium smegmatis. The resistance level decreased in the presence of the efflux pump inhibitors reserpine, carbonyl cyanide m-chlorophenylhydrazone, and verapamil. Energy-dependent efflux of ciprofloxacin from M. smegmatis cells containing the Rv2686c-Rv2687c-Rv2688c operon was observed.
The effect of a meridional flow on Parker's interface dynamo

Parker's interface dynamo is generalized to the case when a homogeneous flow is present in the high-diffusivity (upper) layer in the lateral direction (i.e. perpendicular to the shear flow in the lower layer). This is probably a realistic first representation of the situation near the bottom of the solar convective zone, as the strongly subadiabatic stratification of the tachocline (lower layer in the interface dynamo) imposes a strong upper limit on the speed of any meridional flow there. Analytic solutions to the eigenvalue problem are presented for the cases of vanishing diffusivity contrast and infinite diffusivity contrast. Unlike the trivial case of a homogeneous system, the ability of the meridional flow to reverse the propagation of the dynamo wave is strongly reduced in the interface dynamo. In particular, in the limit of high diffusivity contrast relevant to the solar case it is found that a meridional flow of realistic amplitude cannot reverse the direction of propagation of the dynamo wave. The implications of this result for the solar dynamo problem are discussed.
Prevalence of Cryptosporidium Infection among Inhabitants of 2 Rural Areas in White Nile State, Sudan

Cryptosporidium , a protozoan parasite that causes watery diarrhea, is found worldwide and is common in areas with low water hygiene. In February 2014, 866 stool samples were collected from the inhabitants of 2 rural areas in White Nile State, Sudan. These stool samples were assessed by performing modified acid-fast staining, followed by examination under a light microscope. The overall positive rate of Cryptosporidium oocysts was 13.3%. Cryptosporidium oocysts were detected in 8.6% stool samples obtained from inhabitants living in the area having water purification systems and in 14.6% stool samples obtained from inhabitants living in the area not having water purification systems. No significant difference was observed in the prevalence of Cryptosporidium infection between men and women (14.7% and 14.1%, respectively). The positive rate of oocysts by age was the highest among inhabitants in their 60s (40.0%). These findings suggest that the use of water purification systems is important for preventing Cryptosporidium infection among inhabitants of these rural areas in Sudan.
Can environmental or occupational hazards alter the sex ratio at birth? A systematic review

More than 100 studies have examined whether environmental or occupational exposures of parents affect the sex ratio of their offspring at birth. For this review, we searched Medline and Web of Science using the terms ‘sex ratio at birth’ and ‘sex ratio and exposure’ for all dates, and reviewed bibliographies of relevant studies to find additional articles. This review focuses on exposures that have been the subject of at least four studies including polychlorinated biphenyls (PCBs), dioxins, pesticides, lead and other metals, radiation, boron, and g-forces. For paternal exposures, only dioxins and PCBs were consistently associated with sex ratios higher or lower than the expected 1.06. Dioxins were associated with a decreased proportion of male births, whereas PCBs were associated with an increased proportion of male births. There was limited evidence for a decrease in the proportion of male births after paternal exposure to DBCP, lead, methylmercury, non-ionizing radiation, ionizing radiation treatment for childhood cancer, boron, or g-forces. Few studies have found higher or lower sex ratios associated with maternal exposures. Studies in humans and animals have found a reduction in the number of male births associated with lower male fertility, but the mechanism by which environmental hazards might change the sex ratio has not yet been established.
Are Individuals' Nighttime Sleep Characteristics Prior to Shift‐Work Exposure Predictive for Parameters of Daytime Sleep after Commencing Shift Work?

This study aimed to examine prospectively whether individual nighttime sleep characteristics at baseline (prior to shift‐work exposure) are related to parameters of daytime sleep after commencing shift work. A longitudinal field study was carried out with novice police officers of the Dutch Police Force. A total of 26 subjects were examined at baseline before they entered shift work and re‐examined during follow‐up sessions after four and twelve months of shift‐work exposure. Wrist actigraphy and sleep diaries were used to study nocturnal sleep at baseline and daytime sleep after night shifts during follow‐up sessions. As outcome variables, estimated total sleep time, sleep efficiency, and subjective sleep quality were analyzed. Daytime total sleep time showed a 66 min decline during the first year of shift‐work exposure. Systematic inter‐individual differences were observed for daytime total sleep time and subjective sleep quality (explaining 53% and 38% of the variance, respectively), suggesting potential predictability of these sleep parameters. Although no predictors were found for daytime total sleep time, the subjective quality of nighttime sleep before the onset of shift work predicted 40% of the variance in the subjective quality of daytime sleep after commencing shift work. Follow‐up studies may reveal whether the subjective quality of baseline nighttime sleep also predicts long‐term overall tolerance for shift work.
Investment Effects of Wealth Taxes Under Uncertainty and Irreversiblity

The growing dissatisfaction with perceived distributional inequality and budgetary constraints gave rise to a discussion on the (re-)introduction of wealth taxes. Wealth taxes are typically levied on private wealth, in some countries also on corporate wealth. To avoid misleading statements concerning possible distributional consequences of wealth taxes, preceding analyses of the economic and particularly investment effects are necessary. As investments drive job creation, tax-induced changes in investment timing may significantly affect the income and wealth distribution. We analyze the impact of wealth taxes on investment timing under uncertainty and irreversibility and the propensity to carry out risky projects. Using a Dixit/Pindyck type real options model we find that wealth taxes have real effects. This means that higher wealth tax rates can either stimulate or depress the propensity to invest in risky projects. We find that apparently paradoxical wealth tax effects (accelerated investment due to higher wealth tax rates) are more likely for low interest rates and for high-risk investments. Using either historical cost or fair value accounting may affect investment timing ambiguously. Thus, the design of wealth taxes is crucial for the resulting delay or acceleration of investment. Although our model takes an individual perspective, our findings are also relevant for the current tax policy discussion on the introduction of wealth taxes. Our results indicate that wealth taxes are particularly harmful for specific classes of investments, for example low-risk investments.
The twisted symmetric square L -function of GL(r)

In this paper, we consider the (partial) symmetric square $L$-function $L^S(s,\pi,Sym^2\otimes\chi)$ of an irreducible cuspidal automorphic representation $\pi$ of $\GL_r(\A)$ twisted by a Hecke character $\chi$. In particular, we will show that the $L$-function $L^S(s,\pi,Sym^2\otimes\chi)$ is holomorphic except at $s=0$ and $s=1$, and moreover the possible poles could occur only when $\chi^r\omega^2=1$, where $\omega$ is the central character of $\pi$. Our method of proof is essentially a (nontrivial) modification of the one by Bump and Ginzburg in which they considered the case $\chi=1$.