Miracle-dz/UniFAR-FTUs huggingface dataset:
Prospective risk of stillbirth

Some fraction of any cohort of fetuses alive at a given gestational age will ultimately die before birth. The residual prospective risk of stillbirth as a function of gestational age was calculated from records of the New York City Department of Health covering 370,051 reported births between 1987–1989, including 2454 stillbirths. In the general population, the prospective risk of stillbirth at 26 weeks was one in 150 and, because the time distributions of live births and stillbirths were not proportionate, the risk changed with gestational age. By 40 weeks' gestation, it was one in 475, rising progressively thereafter to one in 375 at 43 weeks. The prospective risk of stillbirth was elevated in certain ethnic groups and increased significantly with advanced maternal age, multiple gestation, and lack of prenatal care. The prospective risk of stillbirth is an important consideration in decisions regarding timing of delivery.
Diffusion-weighted MR for differentiation of breast lesions at 3.0 T: how does selection of diffusion protocols affect diagnosis?

PURPOSE To compare the diagnostic quality of diffusion-weighted (DW) imaging schemes with regard to apparent diffusion coefficient (ADC) accuracy, ADC precision, and DW imaging contrast-to-noise ratio (CNR) for different types of lesions and breast tissue. MATERIALS AND METHODS Institutional review board approval and written, informed consent were obtained. Fifty-one patients with histopathologic correlation or follow-up performed with a 3.0-T MR imager were included in this study. There were 112 regions of interest drawn in 24 malignant, 17 benign, 20 cystic, and 51 normal tissue regions. ADC maps were calculated for combinations of 10 b values (range, 0-1250 sec/mm(2)). Differences in ADC among tissue types were evaluated. The CNRs of lesions at DW imaging were compared for all b values. A repeated-measures analysis of variance was used to assess lesion differentiation. RESULTS ADCs calculated from b values of 50 and 850 sec/mm(2) were 0.99 x 10(-3) mm(2)/sec +/- 0.18 (standard deviation), 1.47 x 10(-3) mm(2)/sec +/- 0.21, 1.85 x 10(-3) mm(2)/sec +/- 0.22, and 2.64 x 10(-3) mm(2)/sec +/- 0.30 for malignant, benign, normal, and cystic tissues, respectively. An ADC threshold level of 1.25 x 10(-3) mm(2)/sec allowed discrimination between malignant and benign lesions with a diagnostic accuracy of 95% (P < .001). ADC calculations performed with multiple b values were not significantly more precise than those performed with only two. We found an overestimation of ADC for maximum b values of up to 1000 sec/mm(2). The best CNR for tumors was identified at 850 sec/mm(2). CONCLUSION Optimum ADC determination and DW imaging quality at 3.0 T was found with a combined b value protocol of 50 and 850 sec/mm(2). This provided a high accuracy for differentiation of benign and malignant breast tumors.
Effect of Stacking Fault Energy on Microstructure and Texture Evolution in Ni-Co Alloys during Severe Plastic Deformation by High Pressure Torsion

The effect of stacking fault energy on microstructure, micro texture and hardness evolution in Ni-Co alloys during severe plastic deformation by high pressure torsion was studied in the present work. For this purpose a series of Ni-Co alloys have been chosen as model alloy systems with composition of Ni-20%Co, Ni-40%Co and Ni-60%Co with decreasing stacking fault energies. These alloys were severe deformed by high pressure torsion (HPT) at room temperature to different number of rotations (N), namely, N=1/12, 1/4, 1/8, 1/2, 1, 3, 5 and 10 under an applied load of 5GPa.
Intervention for Optimal Outcome in Children and Adolescents with a History of Autism

Objective: Autism spectrum disorders (ASDs) were once considered lifelong disorders, but recent findings indicate that some children with ASDs no longer meet diagnostic criteria for any ASD and reach normal cognitive function. These children are considered to have achieved “optimal outcomes” (OO). The present study aimed to retrospectively examine group differences in the intervention history of children and adolescents with OO and those with high-functioning autism (HFA). Method: The current study examined intervention histories in 25 individuals with OO and 34 individuals with HFA (current age, 8–21 years), who did not differ on age, sex, nonverbal intelligence, or family income. Intervention history was collected through detailed parent questionnaires. Results: Children in the OO group had earlier parental concern, received earlier referrals to specialists, and had earlier and more intensive intervention than those in the HFA group. Substantially more children with OO than HFA received applied behavior analysis (ABA) therapy, although for children who received ABA, the intensity did not differ between the groups. Children in the HFA group were more likely to have received medication, especially antipsychotics and antidepressants. There were no group differences in the percent of children receiving special diets or supplements. Conclusion: These data suggest that OO individuals generally receive earlier, more intense interventions, and more ABA, whereas HFA individuals receive more pharmacologic treatments. Although the use of retrospective data is a clear limitation to the current study, the substantial differences in the reported provision of early intervention, and ABA in particular, is highly suggestive and should be replicated in prospective studies.
Protein Import into Subsarcolemmal and Intermyofibrillar Skeletal Muscle Mitochondria

To date, no studies have described the import of proteins in mitochondria obtained from skeletal muscle. In this tissue, mitochondria consist of the functionally and biochemically distinct intermyofibrillar (IMF) and subsarcolemmal (SS) subfractions, which are localized in specialized cellular compartments. This mitochondrial heterogeneity in muscle could be due, in part, to differential rates of protein import. To evaluate this possibility, the import of precursor malate dehydrogenase and ornithine carbamyltransferase proteins was investigated in isolated IMF and SS mitochondria in vitro. Import of these was 3-4-fold greater in IMF compared with SS mitochondria as a function of time. This could account for the higher malate dehydrogenase enzyme activity in IMF mitochondria. Divergent import rates in IMF and SS mitochondria likely result from a differential reliance on various components of the import pathway. SS mitochondria possess a greater content of the molecular chaperones hsp60 and Grp75, yet import is lower than in IMF mitochondria. On the other hand, adriamycin inhibition studies illustrated a greater reliance on acidic phospholipids (i.e. cardiolipin) for the import process in SS mitochondria. Matrix ATP levels were 3-fold higher in IMF mitochondria, but experiments in which ATP depletion was performed with atractyloside and oligomycin illustrated a dissociation between import rates and levels of ATP. In contrast, a close relationship was found between the rate of ATP production (i.e. mitochondrial respiration) and protein import. When respiratory rates in IMF and SS mitochondria were equalized, import rates in both subfractions were similar. These data indicate that 1) import rates are more closely related to the rate of ATP production than the steady state ATP level, 2) import into IMF and SS mitochondrial subfractions is regulated differently, and 3) mitochondrial heterogeneity within a cell type can be due to differences in the rates of protein import, suggesting that this step is a potentially regulatable event in determining the final mitochondrial phenotype.
Measuring spatial preferences at fine-scale resolution identifies known and novel cis-regulatory element candidates and functional motif-pair relationships

Transcriptional regulation is mediated by the collective binding of proteins called transcription factors to cis-regulatory elements. A handful of factors are known to function at particular distances from the transcription start site, although the extent to which this occurs is not well understood. Spatial dependencies can also exist between pairs of binding motifs, facilitating factor-pair interactions. We sought to determine to what extent spatial preferences measured at high-scale resolution could be utilized to predict cis-regulatory elements as well as motif-pairs binding interacting proteins. We introduce the ‘motif positional function’ model which predicts spatial biases using regression analysis, differentiating noise from true position-specific overrepresentation at single-nucleotide resolution. Our method predicts 48 consensus motifs exhibiting positional enrichment within human promoters, including fourteen motifs without known binding partners. We then extend the model to analyze distance preferences between pairs of motifs. We find that motif-pairs binding interacting factors often co-occur preferentially at multiple distances, with intervals between preferred distances often corresponding to the turn of the DNA double-helix. This offers a novel means by which to predict sequence elements with a collective role in gene regulation.
Teachers' Perceptions of Video Games: MMOGs and the Future of Preservice Teacher Education.

No doubt, the ills of American education (e.g., falling achievement levels, declining literacy rates, substandard math and science competency) made visible through high-stakes testing, international comparisons (Gisburg et al. 2005), and school accountability will continue to put pressure on educators to adopt the latest technology for instruction and to upgrade their curriculum and pedagogy based on contemporary learning theory. Meanwhile, theorists who press at the edges of these trends not only argue that we have still not incorporated enough technology into our classrooms to make a difference (Cuban 2000) but also believe that we have not yet moved away from an 18th century notion of what it means to be educated (Schank 2004).
Micro-environmental control of cell migration – myosin IIA is required for efficient migration in fibrillar environments through control of cell adhesion dynamics

Recent evidence suggests that organization of the extracellular matrix (ECM) into aligned fibrils or fibril-like ECM topographies promotes rapid migration in fibroblasts. However, the mechanisms of cell migration that are altered by these changes in micro-environmental topography remain unknown. Here, using 1D fibrillar migration as a model system for oriented fibrillar 3D matrices, we find that fibroblast leading-edge dynamics are enhanced by 1D fibrillar micropatterns and demonstrate a dependence on the spatial positioning of cell adhesions. Although 1D, 2D and 3D matrix adhesions have similar assembly kinetics, both 1D and 3D adhesions are stabilized for prolonged periods, whereas both paxillin and vinculin show slower turnover rates in 1D adhesions. Moreover, actin in 1D adhesions undergoes slower retrograde flow than the actin that is present in 2D lamellipodia. These data suggest an increase in mechanical coupling between adhesions and protrusive machinery. Experimental reduction of contractility resulted in the loss of 1D adhesion structure and stability, with scattered small and unstable adhesions, and an uncoupling of adhesion protein-integrin stability. Genetic ablation of myosin IIA (MIIA) or myosin IIB (MIIB) isoforms revealed that MIIA is required for efficient migration in restricted environments as well as adhesion maturation, whereas MIIB helps to stabilize adhesions beneath the cell body. These data suggest that restricted cell environments, such as 1D patterns, require cellular contraction through MIIA to enhance adhesion stability and coupling to integrins behind the leading edge. This increase in mechanical coupling allows for greater leading-edge protrusion and rapid cell migration.
Genetic Linkage Analysis of 15 DFNB Loci in a Group of Iranian Families with Autosomal Recessive Hearing Loss

Background: Hearing loss (HL) is the most frequent sensory birth defect in humans. Autosomal recessive non-syndromic HL (ARNSHL) is the most common type of hereditary HL. It is extremely heterogeneous and over 70 loci (known as DFNB) have been identified. This study was launched to determine the relative contribution of more frequent loci in a cohort of ARNSHL families. Methods: Thirty-seven Iranian families including 36 ARNSHL families and 1 family with Pendred syndrome each with ≥ 4 affected individuals, from seven provinces of Iran, were ascertained. DFNB1 contribution was initially studied by DNA sequencing of GJB2 and linkage analysis using the relative STR markers. The excluded families were then subjected to homozygosity mapping for fifteen ARNSHL loci. Results: Sixteen families were found to be linked to seven different known loci, including DFNB1 (6 families), DFNB4 (3 families +1 family with Pendred syndrome), DFNB63 (2 families), DFNB2 (1 family), DFNB7/11 (1 family), DFNB9 (1 family) and DFNB21 (1 family). DNA sequencing of the corresponding genes is in progress to identify the pathogenic mutations. Conclusion: The genetic causes were clarified in 43.2% of the studied families, giving an overview of the causes of ARNSHL in Iran. DFNB4 is ranked second after DFNB1 in the studied cohort. More genetic and epigenetic investigations will have to be done to reveal the causes in the remaining families.
Relation of myofibril fragmentation to textural and chemical parameters of aged pork Longissimus dorsi

The relation of myofibrilar fragmentation (length of myofibrilar fragments, myofibrilar fragmentation index) to textural (Warner-Bratzler share force) and chemical parameters (non-protein nitrogen changes) of pork Longisimus dorsi muscles (acquired 24 h post mortem, normal meat quality) were investigated over a 16-day ageing period at 2 °C (± 1 °C). Ageing time significantly affected all parameters at the 1% level or less. The pH value for 16-day aged samples was slightly higher; the average values being 5.61 for nonaged and 5.67 for aged samples. Length of myofibrilar fragments being in average the highest (73 mm) for nonaged samples, and the lowest (15.7 mm and 12.4 mm) for 11 and 16 days aged ones. Myofibrilar fragmentation index increases significantly with storage: for nonaged samples below 30, after a 2-day ageing about 50, and after 5-day ageing 63.7 (determined as described by Olson et al., 1976), or after 11-day ageing 56.9 (determined as described by Hopkins et al., 2004) Indexes for Hopkins procedure were about 7% lower (P ≤ 0.001) compared to those for Olson procedure. Non-protein nitrogen after 11 and 16 days of storage was higher (10.78% and 10.93% of total nitrogen) compared to the nonaged pork (9.39% of total nitrogen). Warner-Bratzler share force was markedly affected by 16-day ageing (nonaged 51.3 N, 16 days 29.2 N). On the basis of instrumentally measured texture differences in thermally treated aged pork we concluded that myofibrilar fragmentation index was a suitable proteolysis rate pointer already from the second day on. The increase in non-protein nitrogen content indicates a release of free amino acids; so, it is a suitable measure of proteolysis after 5 days of ageing.
Effects of flapless implant surgery on soft tissue profiles: a prospective clinical study.

BACKGROUND Flapless implant surgery has been suggested as a suitable treatment modality for the preservation of soft tissue after implant placement. PURPOSE The purpose of this study was to determine the extent of soft tissue profile changes around implants after flapless implant surgery. MATERIALS AND METHODS A total of 44 patients received 76 implants using a flapless implant procedure. The marginal level of the peri-implant soft tissue was evaluated using dental casts 1 week, 1 month, and 4 months after implant placement. RESULTS The mean soft tissue levels around implants showed 0.7 ± 0.3 mm of coronal growth 1 week after surgery. At 1 month, the levels were 0.2 ± 0.2 mm coronal growth and at 4 months, the values were 0.0 ± 0.3 mm. Soft tissue profiles assessed 4 months after flapless implant placement were similar to profiles assessed immediately before implant placement. CONCLUSION Flapless implant surgery is advantageous for preserving mucosal form surrounding dental implants.
Rigel: an architecture and scalable programming interface for a 1000-core accelerator

This paper considers Rigel, a programmable accelerator architecture for a broad class of data- and task-parallel computation. Rigel comprises 1000+ hierarchically-organized cores that use a fine-grained, dynamically scheduled single-program, multiple-data (SPMD) execution model. Rigel's low-level programming interface adopts a single global address space model where parallel work is expressed in a task-centric, bulk-synchronized manner using minimal hardware support. Compared to existing accelerators, which contain domain-specific hardware, specialized memories, and/or restrictive programming models, Rigel is more flexible and provides a straightforward target for a broader set of applications. We perform a design analysis of Rigel to quantify the compute density and power efficiency of our initial design. We find that Rigel can achieve a density of over 8 single-precision GFLOPS/mm2 in 45nm, which is comparable to high-end GPUs scaled to 45nm. We perform experimental analysis on several applications ported to the Rigel low-level programming interface. We examine scalability issues related to work distribution, synchronization, and load-balancing for 1000-core accelerators using software techniques and minimal specialized hardware support. We find that while it is important to support fast task distribution and barrier operations, these operations can be implemented without specialized hardware using flexible hardware primitives.
A novel way of computing similarities between nodes of a graph, with application to collaborative recommendation

This work presents a new perspective on characterizing the similarity between elements of a database or, more generally, nodes of a weighted, undirected graph. It is based on a Markov-chain model of random walk through the database. The suggested quantities, representing dissimilarities (or similarities) between any two elements, have the nice property of decreasing (increasing) when the number of paths connecting those elements increases and when the "length" of any path decreases. The model is evaluated on a collaborative recommendation task where suggestions are made about which movies people should watch based upon what they watched in the past. The model, which nicely fits into the so-called "statistical relational learning" framework as well as the "link analysis" paradigm, could also be used to compute document or word similarities, and, more generally could be applied to other database or Web mining tasks.
Secretory properties of eosinophils

Eosinophils are prominent in the pathology of asthma and allergic disease, and recognition of the biological functions of eosinophil secretory proteins has been an important factor in appreciating the proinflammatory role of the cells. The major biological activity of the cationie granule proteins is their cytotoxicity towards cells such as respiratory epithelium and nervous tissue [1]. Despite the importance of eosinophils in this regard, little is known about the mechanisms that regulate the release of granule contents. Our present understanding of the mechanisms controlling the latter stages of the process of regulated secretion of granule proteins (exocytosis) has come about largely through the use of permeabilised secretory cells in which the conditions pertaining in the cytosolic compartment are open to direct manipulation from the exterior. Permeabilisation can be achieved by a number of methods [2] that produce lesions of various sizes and tenure. The technique has been applied to a diverse range of cell types [3], and Ca2+ and/or guanine nucleotides have heen found to be the principal effectors of exocytosis. However, subtle differences in the control mechanisms must exist to account for the diversity of responsiveness seen between cell types. In mast cells Ca2+ and a guanine nucleotide are essential for exocytosis, although elevation of one reduces the requirement for the other suggesting an interaction between their respective binding proteins. By comparison, for example, the secretion of neurotransmitters from nerve terminals, whilst under Câ "*" control, is exceptional for its millesecond kinetics; the non-hydrolysable analogue of GTP GTP-7-S Cguanosine-5'-0-C3-thiotriphosphate) induces secretion from parathyroid cells that is inhibited by increased concentrations of Ca2+; and GTP, acting through a G-protein, inhibits a2-adrenergic receptor induced secretion of insulin. These differences suggest that there may he opportunities to achieve selective modulation of the exocytotic responsive of one cell type without compromising the activity of other secretory cells. )
Generous economic investments after basolateral amygdala damage

Contemporary economic models hold that instrumental and impulsive behaviors underlie human social decision making. The amygdala is assumed to be involved in social-economic behavior, but its role in human behavior is poorly understood. Rodent research suggests that the basolateral amygdala (BLA) subserves instrumental behaviors and regulates the central-medial amygdala, which subserves impulsive behaviors. The human amygdala, however, typically is investigated as a single unit. If these rodent data could be translated to humans, selective dysfunction of the human BLA might constrain instrumental social-economic decisions and result in more impulsive social-economic choice behavior. Here we show that humans with selective BLA damage and a functional central-medial amygdala invest nearly 100% more money in unfamiliar others in a trust game than do healthy controls. We furthermore show that this generosity is not caused by risk-taking deviations in nonsocial contexts. Moreover, these BLA-damaged subjects do not expect higher returns or perceive people as more trustworthy, implying that their generous investments are not instrumental in nature. These findings suggest that the human BLA is essential for instrumental behaviors in social-economic interactions.
Decision procedures and expressiveness in the temporal logic of branching time

In this paper we consider the Computation Tree Logic (CTL) proposed in [CE] which extends the Unified Branching Time Logic (UB) of [BMP] by adding an until operator. We establish that CTL has the small property by showing that any satisfiable CTL formulae is satisfiable in a small finite model obtained from a small -&-ldquo;pseudo-model-&-rdquo; resulting from the Fischer Ladner quotient construction. We then give an exponential time algorithm for deciding satisfiability in CTL, and extend the axiomatization of UB given in [BMP] to a complete axiomatization for CTL. Lastly, we study the relative expressive power of a family of temporal logics obtained by extending or restricting the syntax of UB and CTL.