Miracle-dz/UniFAR-FTUs huggingface dataset:
Reciprocal Transcriptional and Posttranscriptional Growth-Phase-Dependent Expression of sfh, a Gene That Encodes a Paralogue of the Nucleoid-Associated Protein H-NS

ABSTRACT The IncHI1 self-transmissible plasmid pSf-R27 from Shigella flexneri 2a strain 2457T harbors sfh, a gene that codes for a protein with strong amino acid sequence homology to the global transcription regulator and nucleoid-associated protein H-NS and to its paralogue, StpA. Previously, we discovered that the expression of sfh mRNA is growth phase dependent such that in cultures growing in Lennox broth at 37°C, the transcript is readily detectable in the early stages of exponential growth but is not detectable at the onset of stationary phase. In contrast, the Sfh protein is poorly expressed in early-exponential growth when sfh mRNA is abundant whereas it is expressed to a high level in early stationary phase, when sfh transcript expression is low (P. Deighan, C. Beloin, and C. J. Dorman, Mol. Microbiol. 48:1401-1416, 2003). This unusual pattern of reciprocal mRNA and protein expression is not due to growth phase-dependent effects on either mRNA or protein stability, nor is it due to the known abilities of the Sfh, StpA, and H-NS proteins to influence sfh gene expression. Instead, our data point to a blockade of sfh mRNA translation in early-exponential growth that is relieved as the culture enters the stationary phase of growth. Replacing the 5′ end and translation initiation signals of the sfh mRNA with heterologous sequences did not alter the growth phase-dependent expression of the Sfh protein, suggesting that growth phase control of translation is intrinsic to another component of the message.
Long-Read Sequencing of Chicken Transcripts and Identification of New Transcript Isoforms

The chicken has long served as an important model organism in many fields, and continues to aid our understanding of animal development. Functional genomics studies aimed at probing the mechanisms that regulate development require high-quality genomes and transcript annotations. The quality of these resources has improved dramatically over the last several years, but many isoforms and genes have yet to be identified. We hope to contribute to the process of improving these resources with the data presented here: a set of long cDNA sequencing reads, and a curated set of new genes and transcript isoforms not currently represented in the most up-to-date genome annotation currently available to the community of researchers who rely on the chicken genome.
A Constraint on Z☉ from Fits of Isochrones to the Color-Magnitude Diagram of M67

The mass at which a transition is made between stars that have radiative or convective cores throughout the core H burning phase is a fairly sensitive function of Z (particularly, the CNO abundances). As a consequence, the ~4 Gyr, open cluster M67 provides a constraint on Z☉ (and the solar heavy-element mixture) because (1) high-resolution spectroscopy indicates that this system has virtually the same metal abundances as the Sun, and (2) its turnoff stars have masses just above the lower limit for sustained core convection on the main sequence. In this study, evolutionary tracks and isochrones using the latest MARCS model atmospheres as boundary conditions have been computed for 0.6-1.4 ℳ☉ on the assumption of a metals mix (implying Z☉ ≈ 0.0125) based on the solar abundances derived by M. Asplund and collaborators using 3D model atmospheres. These calculations do not predict a turnoff gap where one is observed in M67. No such difficulty is found if the analysis uses isochrones for Z☉ = 0.0165, assuming the Grevesse and Sauval mix of heavy elements. Our findings, like the inferences from helioseismology, indicate a problem with the abundances of Asplund and collaborators. However, it is possible that low-Z models with diffusive processes taken into account will be less problematic.
Computing , Artificial Intelligence and Information Technology Using neural networks and cognitive mapping in scenario analysis : The case of Turkey s inflation dynamics S ule €

This paper has two objectives. First of all, it proposes a dynamic scenario analysis approach, which is a revised version of extended anomaly relaxation (EFAR) model [J. Operat. Res. Soc. 48 (1997) 793]; hereafter referred to as REFAR. REFAR aims to eliminate the basic drawbacks of EFAR and improve its efficiency. The basic steps of REFAR are presented and the improvement with respect to the original version realized in each step is emphasized. The second objective of the study is to estimate the future of inflation in Turkey through REFAR using data corresponding to the period January 1994–December 1998. The main reasons for selecting REFAR-based inflation estimation instead of adopting traditional forecasting techniques are explained. The basic scenarios finally reached through REFAR, the transition among each key scenario as well as among the scenarios grouped under each key scenario are explained in detail and the validity of the REFAR-based inflation estimation model is tested through several case studies. 2003 Elsevier B.V. All rights reserved.
Time-domain Non-monte Carlo Noise Simulation For Nonlinear Dynamic Circuits With Arbitrary Excitations

A new, <italic>time-domain, non-Monte Carlo</italic> method for computer simulation of <italic>electrical noise</italic> in <italic>nonlinear dynamic circuits</italic> with <italic>arbitrary excitations</italic> is presented. This time-domain noise simulation method is based on the results from the theory of <italic>stochastic differential equations</italic>. The noise simulation method is general in the sense that any <italic>nonlinear dynamic circuit</italic> with <italic>any kind of excitation</italic>, which can be simulated by the <italic>transient analysis</italic> routine in a <italic>circuit simulator</italic>, can simulated by our noise simulator in time-domain to produce the noise variances and covariances of circuit variables as a function of time, provided that noise models for the devices in the circuit are available. Noise <italic>correlations</italic> between circuit variables at <italic>different time points</italic> can also be calculated. Previous work on computer simulation of noise in integrated circuits is reviewed with comparisons to our method. Shot, thermal and flicker noise models for integrated-circuit devices, in the context of our time-domain noise simulation method, are described. The implementation of this noise simulation method in a circuit simulator (SPICE) is described. Two examples of noise simulation (a CMOS ring-oscillator and a BJT active mixer) are given.
Do bond issuers shop for a better credit rating ?

By utilizing a large sample of US bond issuers with ratings from Moody's, S&P, and Fitch, this paper analyses whether observed differences in average rating levels between the third agency Fitch and the mandatory agencies Moody's and S&P are due to issuers seeking only an additional rating if it is expected to give a more favorable picture of credit quality. In contrast to previous research, we also ask why some issuers possibly do expect to obtain an upwardly biased credit risk assessment from Fitch. The analysis reveals strong evidence of rating shopping behavior. In addition, issuers having an added incentive to press Fitch for a better rating are more likely to solicit a third rating. Finally, by comparing Fitch's rating class default probabilities estimated for issuers with and without an observed Fitch rating, we nd that the default risks associated with a particular rating class are signi cantly increased for the rst group.
Can We Determine Our Own Happiness? Core Self-Evaluation as Related to Job and Relationship Satisfaction

College is a double-edged sword in that it is often seen as a time of newfound freedom and fun, but also described as a core source of stress. Considerable research suggests that one’s tolerance to stress is directly related to personality factors that determine general life satisfaction. However, evidence suggests core self-evaluation, a personality factor consisting of self-esteem, self-efficacy, locus of control, and emotional stability, is linked to not just general life satisfaction, but specific types of life satisfaction, such as one’s job. This study utilizes a survey to examine the relationship between core self-evaluation and college satisfaction, relationship satisfaction, and coping skills among 161 college students. I find statistical significance in between all three relationships core self-evaluation being positively related to job and relationship satisfaction and coping skills – and discuss the possible reasons behind why. These findings not only help to shed light on a new personality variable that can determine satisfaction, but also offer insight into how internal factors can manifest in one’s everyday life.
Neuropsychological Outcomes of U.S. Veterans with Report of Remote Blast-Related Concussion and Current Psychopathology

Abstract This study explored whether remote blast-related MTBI and/or current Axis I psychopathology contribute to neuropsychological outcomes among OEF/OIF veterans with varied combat histories. OEF/OIF veterans underwent structured interviews to evaluate history of blast-related MTBI and psychopathology and were assigned to MTBI (n = 18), Axis I (n = 24), Co-morbid MTBI/Axis I (n = 34), or post-deployment control (n = 28) groups. A main effect for Axis I diagnosis on overall neuropsychological performance was identified (F(3,100) = 4.81; p = . 004), with large effect sizes noted for the Axis I only (d = .98) and Co-morbid MTBI/Axis I (d = .95) groups relative to the control group. The latter groups demonstrated primary limitations on measures of learning/memory and processing speed. The MTBI only group demonstrated performances that were not significantly different from the remaining three groups. These findings suggest that a remote history of blast-related MTBI does not contribute to objective cognitive impairment in the late stage of injury. Impairments, when present, are subtle and most likely attributable to PTSD and other psychological conditions. Implications for clinical neuropsychologists and future research are discussed. (JINS, 2012, 18, 1–11)
From the Hands into the Eyes: An Analysis of Children's American Sign Language Story Comprehension

This thesis provides an insight into how native ASL children are making meaning and drawing upon language cueing systems, and into the commonal ities of eye behaviour demonstrated when they decipher/deconstruct ASL stories on video. S tudies of ASL linguistics and ASL literature are critical, but historically neglected, component s of bilingual ASL-English education. While teaching ASL as a language of study in my classroom , I observed how students comprehended ASL stories. In the absence of formal standardized ASL comprehension assessments for classroom teachers, I explored Kintsch’s theory of comprehension and the use of language cueing systems as a way to conceptualize ASL story c mprehension. Findings show that native ASL children have a higher rate of comprehension wh en t ey are drawing upon ASL language cueing systems when deciphering/deconstructing ASL stories. Children’s use of the eyebrows and eye gaze seem to be a part of their deciphering /deconstructing behaviour, and need to be explored further.
ATTACHMENT I--FINAL RISK ASSESSMENT OF CLOSTRIDIUM ACETOBUTYLICUM

Clostridium acetobutylicum is an anaerobic, saccharolytic and proteolytic bacterium that has been isolated from a number of environments. The bacterium produces endospores which allows for long-term survival in the environment even in the presence of oxygen. It exists in the biologically inactive spore stage in soils except when vegetative growth is stimulated by anaerobiosis and other favorable growth conditions. Although other members of the genus produce some of the most lethal neurotoxins known, C. acetobutylicum is considered a benign microorganism. Throughout its long history of use for production of acetone and butanol, there have been no reports of adverse effects to human health or the environment. It is not pathogenic or toxigenic to humans, animals, or plants. The potential risks associated with the use of this bacterium in fermentation facilities are low.
Elastic Spectrum Allocation for Time-Varying Traffic in FlexGrid Optical Networks

Elastic flexgrid optical networks (FG-ON) are considered a very promising solution for next-generation optical networks. In this article we focus on lightpath adaptation under variable traffic demands in FG-ON. Specifically, we explore the elastic spectrum allocation (SA) capability of FG-ON and, in this context, we study the effectiveness of three alternative SA schemes in terms of the network performance. To this end, we formulate a Multi-Hour Routing and Spectrum Allocation (MH-RSA) optimization problem and solve it by means of both Integer Linear Programming (ILP) and efficient heuristic algorithms. Since, as numerical results show, the effectiveness of SA schemes highly depends on the traffic demand profile, we formulate some indications on the applicability of elastic SA in FG-ON.
Clinical Effects and Antivenom Dosing in Brown Snake (Pseudonaja spp.) Envenoming — Australian Snakebite Project (ASP-14)

Background Snakebite is a global health issue and treatment with antivenom continues to be problematic. Brown snakes (genus Pseudonaja) are the most medically important group of Australian snakes and there is controversy over the dose of brown snake antivenom. We aimed to investigate the clinical and laboratory features of definite brown snake (Pseudonaja spp.) envenoming, and determine the dose of antivenom required. Methods and Finding This was a prospective observational study of definite brown snake envenoming from the Australian Snakebite Project (ASP) based on snake identification or specific enzyme immunoassay for Pseudonaja venom. From January 2004 to January 2012 there were 149 definite brown snake bites [median age 42y (2–81y); 100 males]. Systemic envenoming occurred in 136 (88%) cases. All envenomed patients developed venom induced consumption coagulopathy (VICC), with complete VICC in 109 (80%) and partial VICC in 27 (20%). Systemic symptoms occurred in 61 (45%) and mild neurotoxicity in 2 (1%). Myotoxicity did not occur. Severe envenoming occurred in 51 patients (38%) and was characterised by collapse or hypotension (37), thrombotic microangiopathy (15), major haemorrhage (5), cardiac arrest (7) and death (6). The median peak venom concentration in 118 envenomed patients was 1.6 ng/mL (Range: 0.15–210 ng/mL). The median initial antivenom dose was 2 vials (Range: 1–40) in 128 patients receiving antivenom. There was no difference in INR recovery or clinical outcome between patients receiving one or more than one vial of antivenom. Free venom was not detected in 112/115 patients post-antivenom with only low concentrations (0.4 to 0.9 ng/ml) in three patients. Conclusions Envenoming by brown snakes causes VICC and over a third of patients had serious complications including major haemorrhage, collapse and microangiopathy. The results of this study support accumulating evidence that giving more than one vial of antivenom is unnecessary in brown snake envenoming.
Analisis Perilaku Penerimaan EDMODO pada Perkuliahan Dengan Model UTAUT

Penggunan perangkat e-learning di STIKOMDB diharapkan dapat meningkatkan efektifitas dan efisiensi pembelajaran. Penelitian ini bertujuan untuk menganalisa penerimaan perangkat e-learning pada pembelajaran menggunakan Unified Theory of Acceptance and Use of Technology ( UTAUT ). Responden penelitian adalah mahasiswa STIKOMDB yang menggunakan perangkat e-learning pada pembelajaran. Data dikumpulkan menggunakan metode survey. Data dianalisa menggunakan Structural Equation Model (SEM). Penelitian menunjukkan bahwa that Expectancy Performance , Price Value dan Habit memiliki pengaruh yang signifikan terhadap Behavioral Intention . Sedangkan Effort Expectancy, Facilitating Condition, Social Influence dan Hedonic Motivation tidak memiliki pengaruh terhadap Behavioral Intention. Model penelitian menghasilkan nilai R2 sebesar 0.639 yang memiliki arti bahwa model cukup subtansial untuk memprediksi penerimaan perangkat e-Learning pada pembelajaran
Communication Behaviors and Trust in Collaborative Online Teams

This study investigates preservice teachers' trust levels and collaborative communication behaviors namely leadership, feedback, social interaction, enthusiasm, task and technical uncertainties, and task-oriented interactions in online learning environment. A case study design involving qualitative and quantitative data collection and analysis was employed. The sample consisted of 32 (24 female, 8 male) 3 rd year foreign language education students who enrolled in the "Instructional Technology and Material Development" course at Middle East Technical University in Ankara, Turkey. The participants were involved in a four-month online project in the 'Learning to Teach with Technology Studio' (LTTS) course at Indiana University in the US to create a technology supported project-based learning unit for foreign language learners. At the end of the fourteen-week period, the participants filled out the online Group Trust Questionnaire consisting eight five-point Likert-type items and two open-ended questions. To identify the participants' online interactions, online discussion archives of the groups were analyzed. The findings showed that the groups with different trust levels showed different communication behaviors throughout the study, and midpoint of the group life was found critical moment for increasing or decreasing pattern of communication behaviors.
The early diagnosis of lung cancer

Earlier diagnosis of malignant disease in the lung may bring about improvements in the treatment. This article discusses the effects of early diagnosis on the prognosis. Cancer of the lung may be associated with other lung pathology, thus increasing the problems of diagnosis. Diagnosis depends on radiological examination, cytology of the sputum, radio-isotope lung scanning and mediastinoscopy: an account is given of how these may be used to diagnose the condition whilst it is still at an early stage and suitable for radical treatment.
Peranan Kepala Sekolah Dalam Pelaksanaan Pendidikan Karakter Di Sekolah Menengah Pertama (SMP) Di Kecamatan Sindue

This research aims to describe (1) the condition of the character of students, (2) functions, adjustment, and the process undertaken in the implementation of the principal character education, (3) development of a flagship character performed the principal. Methods used is a descriptive with a descriptive qualitative data analysis techniques of interactive models, Miles and Huberman, and Likert scale question form analysis. The population in this study is a entire principal a number of 5 persons, a number of 118 teachers, and students to a number of people at 1,041 person in Sindue Sub-district. Sample. The number of samples of the principal amounts of 5 people using sampling a number of principal samples are saturated, 280 students are divided into 56 school 5 pupils by school using random sampling techniques, sample teacher as much as 90 people are divided into 18 schools teachers by school using random sampling techniques. Engineering data retrieval using descriptive analysis and interview guide scale Likert. The results showed that: first, the character of the students in junior high se Sindue Sub-district is divided into (1) characters are weak, (2) strong characters , (3) the character of ugly, (4) good characters. Second, the function, and the process of adjustment, in character education is done in General by the principal, the difference is how to encourage teachers and students in carrying outactivities of character education in their respective junior high school. Third, the pre-eminent character development done by the head of the junior school is generally done by dissemination to the program the extracurricular activities. The thing that distinguishes is awarding tasks in a community environment is only done by the head of the junior school the country 5 Sindue.
From constitutional rule to loosely coupled spheres of liquid authority: a reflexive approach

This article develops a reason-based social foundation of new forms of authority, which often are liquid and sectorally limited. The recognition of authority hinges, in this view, on reflexive actors who are aware of their own limits of rationality regarding the lack of either information or a perspective that allows for the pursuit of common goods. In such a reflexive concept of authority, authority takers tend to monitor the authorities closely, and the internalization of the subordinate role is not a necessary part of it. Reflexive authority is embedded in the acceptance of a knowledge order that reproduces the authority relationship. In spite of a tendency toward institutionalization, reflexive authority often comes in a liquid state of aggregation, and almost always with a restricted functional scope. Moreover, this new set-up of authority creates social dynamics that add to liquidity. First, the encompassing constitutionalized rule with majoritarian decision making as major source of legitimacy is increasingly undermined by loosely coupled spheres of specialized authorities, which are most often justified on the basis of expertise. We can observe both the rise of international authorities in the absence of coordination between them, and the rise of similar authorities within the nation state that escape control of the democratic core institutions. As a result, authority gets fragmented and different authorities need to adjust to each other. The second implication of the argument is that democratic legitimation narratives become rare, leading to an ongoing legitimatory contestation of authorities. Both these processes make authority even more liquid.
No Differences in Emotion Recognition Strategies in Children with Autism Spectrum Disorder: Evidence from Hybrid Faces

Emotion recognition problems are frequently reported in individuals with an autism spectrum disorder (ASD). However, this research area is characterized by inconsistent findings, with atypical emotion processing strategies possibly contributing to existing contradictions. In addition, an attenuated saliency of the eyes region is often demonstrated in ASD during face identity processing. We wanted to compare reliance on mouth versus eyes information in children with and without ASD, using hybrid facial expressions. A group of six-to-eight-year-old boys with ASD and an age- and intelligence-matched typically developing (TD) group without intellectual disability performed an emotion labelling task with hybrid facial expressions. Five static expressions were used: one neutral expression and four emotional expressions, namely, anger, fear, happiness, and sadness. Hybrid faces were created, consisting of an emotional face half (upper or lower face region) with the other face half showing a neutral expression. Results showed no emotion recognition problem in ASD. Moreover, we provided evidence for the existence of top- and bottom-emotions in children: correct identification of expressions mainly depends on information in the eyes (so-called top-emotions: happiness) or in the mouth region (so-called bottom-emotions: sadness, anger, and fear). No stronger reliance on mouth information was found in children with ASD.