Miracle-dz/UniFAR-FTUs huggingface dataset:
Immunohistochemical distribution of heat shock protein 70 and proliferating cell nuclear antigen in mouse placenta at different gestational stages

The aim of the present study was to investigate immunohistochemical distribution of heat shock protein 70 (Hsp70) and proliferating cell nuclear antigen (PCNA) in the mouse placenta at different gestational stages. For this purpose a total of 18 Swiss albino female mice at 12–14 weeks of age were used. Females were sacrificed on days 3 (early), 10 (mid‐), and 17 (late) of pregnancy and the implantation sites of the pregnant uterus were sampled. The sections were made transversely through the central region of the implantation site and stained with hematoxylin and eosin for histological examination. PCNA and Hsp70 was stained immunohistochemically. Since the definitive placenta was not still formed on day 3 of pregnancy, Hsp70 and PCNA positivity were evaluated in only luminal epithelium and decidual‐stromal cells. On days 10 and 17 of pregnancy, Hsp70 and PCNA positivity were evaluated in labyrinth zone, junctional zone and decidual layer of placenta. Hsp70 expression was observed trophoblast cells and decidual cells and was relatively constant throughout the pregnancy. This protein was strongly labeled in the trophoblast cells; while decidual cells were displayed moderate staining. In early pregnant mouse uteri, PCNA was mainly localized in decidual‐stromal cells. The trophoblast cells and decidual cells displayed highly proliferative activity at the midgestational period. However there was a significant decrease in the percentage of PCNA positive cells in late gestation. Microsc. Res. Tech. 79:251–257, 2016. © 2016 Wiley Periodicals, Inc.
Understanding trust and perceived usefulness in the consumer acceptance of an e-service: a longitudinal investigation

ABSTRACT E-services remain characterised by uncertainty despite their proliferation. Consumer trust beliefs are therefore considered an important determinant of e-service adoption. However, the research has not yet considered the potentially dynamic nature of these trust beliefs or how early-stage trust might influence later-stage adoption and use. To address this gap, this study draws on the theory of reasoned action and expectation–confirmation theory in a longitudinal study of trust in e-services. We examine how trust interacts with other consumer beliefs such as perceived usefulness (PU) and how these beliefs together influence consumer intentions and behaviours concerning e-services at both the initial and latter stages of use. The empirical context is online health information services. Data collection on a student population occurred during two time periods approximately five weeks apart. The results show that PU and trust are important at both the initial and latter stages in the consumer acceptance of online health services. Consumers’ actual usage experiences modify perceptions of usefulness and influence the confirmation of their initial expectations. These results have implications for our understanding of the dynamic nature of trust and PU as well as their roles in the long-term sustainability of e-services.
The acute effects of various types of stretching static, dynamic, ballistic, and no stretch of the iliopsoas on 40-yard sprint times in recreational runners.

BACKGROUND AND PURPOSE The potential adverse effects of static stretching on athletic performance are well documented, but still appears to be controversial, especially as they relates to sprinting. The prevalence of this practice is demonstrated by the number of competitive and recreational athletes who regularly engage in stretching immediately prior to sprinting with the mindset of optimizing their performance. The purpose of this study was to examine the effects of acute static, dynamic, and ballistic stretching, and no stretching of the iliopsoas muscle on 40-yard sprint times in 18-37 year-old non-competitive, recreational runners. METHODS Twenty-five healthy recreational runners (16 male and 9 female) between the ages of 24 and 35 (Mean = 26.76 yrs., SD = 2.42 yrs.) completed this study. A repeated measures design was used, which consisted of running a 40-yard sprint trial immediately following each of 4 different stretching conditions aimed at the iliopsoas muscle and lasting 1 minute each. The 4 conditions were completed in a randomized order within a 2-week time period, allowing 48-72 hours between each condition. Prior to each 40-yard sprint trial, a 5-minute walking warm-up was performed at 3.5 mph on a treadmill. The subject then ran a baseline 40-yard sprint. After a 10-minute self-paced walk, each subject performed one of the 4 stretching conditions (ballistic, dynamic, static, and no stretch) and then immediately ran a timed 40-yard sprint. RESULTS There was a significant interaction between stretching conditions and their effects on sprint times, F(3,72) = 9.422, p<. 0005. To break down this interaction, simple main effects were performed with 2 repeated measures ANOVAs and 4 paired t-tests using a Bonferroni corrected alpha (α = .0083). There were no significant differences between the 4 pre-condition times, p = 0.103 (Greenhouse-Geisser) or the post-condition times, p = 0.029. In the no stretch condition, subjects improved significantly from pre- to post- sprint times (p<0.0005). There were no statistically significant differences in pre- and post-stretch condition sprint times among the static (p = 0.804), ballistic (p = 0.217), and dynamic (p = 0.022) stretching conditions. CONCLUSIONS Sprint performance may show greatest improvement without stretching and through the use of a walking generalized warmup on a treadmill. These findings have clinically meaningful implications for runners who include iliopsoas muscle stretching as a component of the warm-up. LEVEL OF EVIDENCE Level 2.
MID-INFRARED SPECTRAL DIAGNOSTICS OF LUMINOUS INFRARED GALAXIES

We present a statistical analysis of the mid-infrared (MIR) spectra of 248 luminous infrared (IR) galaxies (LIRGs) which comprise the Great Observatories All-sky LIRG Survey (GOALS) observed with the Infrared Spectrograph (IRS) on board the Spitzer Space Telescope. The GOALS sample enables a direct measurement of the relative contributions of star formation and active galactic nuclei (AGNs) to the total IR emission from a large sample of local LIRGs. The AGN contribution to the MIR emission (fAGN) is estimated by employing several diagnostics based on the properties of the [Ne v], [O iv], and [Ne ii] fine-structure gas emission lines, the 6.2 μm polycyclic aromatic hydrocarbon (PAH), and the shape of the MIR continuum. We find that 18% of all LIRGs contain an AGN and that in 10% of all sources the AGN contributes more than 50% of the total IR luminosity. Summing up the total IR luminosity contributed by AGNs in all our sources suggests that AGNs supply ∼12% of the total energy emitted by LIRGs. The average spectrum of sources with an AGN looks similar to the average spectrum of sources without an AGN, but it has lower PAH emission and a flatter MIR continuum. AGN-dominated LIRGs have higher IR luminosities, warmer MIR colors, and are found in interacting systems more often than pure starburst LIRGs. However, we find no linear correlations between these properties and fAGN. We used the IRAC colors of LIRGs to confirm that finding AGNs on the basis of their MIR colors may miss ∼40% of AGN-dominated (U)LIRGs.
Cutting through the smoke: the diversity of microorganisms in deep-sea hydrothermal plumes

There are still notable gaps regarding the detailed distribution of microorganisms between and within insular habitats such as deep-sea hydrothermal vents. This study investigates the community composition of black smoker vent microorganisms in the Southern Hemisphere, and changes thereof along a spatial and chemical gradient ranging from the vent plume to surrounding waters. We sampled two hydrothermal vent fields, one at the South West Indian Ridge (SWIR), the other at the East Scotia Ridge (ESR). Samples were collected across vent fields at varying vertical distances from the origin of the plumes. The microbial data were sequenced on an Illumina MiSeq platform for the 16SrRNA gene. A substantial amount of vent-specific putative chemosynthetic microorganisms were found, particularly in samples from focused hydrothermal venting. Common vent-specific organisms from both vent fields were the genera Arcobacter, Caminibacter and Sulfurimonas from the Epsilonproteobacteria and the SUP05 group from the Gammaproteobacteria. There were no major differences in microbial composition between SWIR and ESR for focused plume samples. However, within the ESR the diffuse flow and focused samples differed significantly in microbial community composition and relative abundance. For Epsilonproteobacteria, we found evidence of niche-specificity to hydrothermal vent environments. This taxon decreased in abundance by three orders of magnitude from the vent orifice to background water. Epsilonproteobacteria distribution followed a distance–decay relationship as vent-effluents mixed with the surrounding seawater. This study demonstrates strong habitat affinity of vent microorganisms on a metre scale with distinct environmental selection.
Labouring to Learn: Students’Debt and Term Time Employment in Belfast

This paper presents the results of a survey into the labour market experiences of 363 undergraduate students in the Department of Sociology and Social Policy at Queen's University, Belfast. The first pan of the paper will look at the debate surrounding the introduction of the Student Loans Scheme and the associated abolition of welfare benefit entitlements. The second pan of the paper will present the findings of the survey. Particular reference will be made to the financial situation facing undergraduate students and the extent to which term-time employment presents a solution to their monetary problems.
Size matters! How position sizing determines risk and return of technical timing strategies

The application of a technical trading rule, which just provides long and short signals, requires the investor to decide upon the exposure to stake in each trade. Although this position sizing (or money management) crucially affects the risk and return characteristics, recent academic literature has largely ignored this effect, leaving reported results incomparable. This work systematically analyzes the impact of position sizing on timing strategies and clarifies the relation to the Kelly criterion, which proposes to bet relative fractions from the remaining gambling budget. Both erratic as well as different relative positions, i.e. fixed proportions of the remaining portfolio value, are compared for simple moving average trading rules. The simulation of parametrized return series allows systematically varying those asset price properties, which are most in uential on timing results: drift, volatility, and autocorrelation. The study reveals that the introduction of relative position sizing has a severe impact on trading results compared to erratic positions. In contrast to a standard Kelly framework, however, an optimal position size does not exist. Interestingly, smaller trading fractions deliver the highest risk-adjusted returns in most scenarios.
Social Status Polarization in the Timing and Trajectories to Motherhood

This paper examines the polarization by social status of Canadian women’s timing and trajectories to motherhood. The study applies event history analysis on data gathered through the 2001 General Social Survey on Family History and focuses on women born from 1922 to 1980. Women with high social status are more likely to delay their entry into motherhood and to follow normatively preferred trajectories that include graduation from post-secondary education. In contrast, women with low social status are more likely to follow shorter routes, often bypassing graduation from post-secondary education, regular work, or marriage, and consequently become mothers at younger age.
Meteor Showers or Heat Waves? Heteroskedastic Intra-Daily Volatility in the Foreign Exchange Market

This paper defines and tests a form of market efficiency called market dexterity which requires that asset prices adjust instantaneously and completely in response to new information. Examining the behavior of the yen/dollar exchange rate while each of the major markets are open it is possible to test for informational effects from one market to the next. Assuming that news has only country specific autocorrelation such as a heat wave. any intra-daily volatility spillovers (meteor showers) become evidence against market dexterity. ARCII models are employed to model heteroskedasticity across intra-daily market segments. Statistical tests lead to the rejection of the heat wave and therefore the market dexterity hypothesis. Using a volatility type of vector autoregression we examine the impact of news in one market on the time path of volatility in other markets.
Pharmacokinetics of Dichloroacetate in Adult Patients with Lactic Acidosis

The pharmacokinetic properties of the lactate‐lowering drug dichloroacetate were investigated in 111 adult patients with lactic acidosis who were randomized to receive dichloroacetate as part of a placebo‐controlled clinical trial. The clinical symptoms and etiology of lactic acidosis varied markedly among patients. Dichloroacetate, at a dose of 50 mg per kilogram of body weight, was administered in a 30‐minute intravenous infusion into a peripheral vein. A second dose, identical to the first, was administered 2 hours after beginning the first infusion. Plasma levels of dichloroacetate were determined from blood samples collected periodically up to 288 hours after administration and the data were subjected to pharmacokinetic modeling. The pharmacokinetic properties of dichloroacetate in these acutely ill patients were complex and differed markedly from those in healthy volunteers, whose data fitted a one‐compartment pharmacokinetic model. In contrast, the data from patients fitted one‐, two‐, or three‐compartment pharmacokinetic models or even none of these, depending on the individual. Drug clearance in plasma tended to decrease as the number of compartments required to fit the data increased or as the number of drug treatments increased.
Market Structure and Audit Fees: A Local Analysis*

This study conducts a local analysis of the relation between market structure and audit fees. The research question of interest to us is how audit fees are determined by each practicing local office, after taking into account the auditor's own position in a local market and the influence exerted by his or her clients. Appealing to the economic theories of monopoly and monopsony power, we hypothesize a positive audit fee-concentration relation, and a negative audit fee-client influence relation. Results indicate that auditor market concentration is positively associated with the non-Big 6 audit fees but is unrelated to the Big 6 audit fees. Evidence is mixed concerning the client influence hypothesis. When this construct is proxied by the number of rival auditors operating within a geographic area centered on the municipality, the prediction of negative audit fee-client influence relation is strongly supported for both groups of auditors. Results are much weaker using measures developed based on the relative importance of a municipal client to its auditor's audit portfolio. The issues addressed in this study are important at a time when the Canadian municipal sector is undergoing major changes because of municipal amalgamation, altering the underlying market structure for audit services and the bargaining position of a municipality vis-A-vis its auditor. More broadly speaking, our analysis implies that when assessing an auditor's report for signs of client pressure, the professional oversight bodies and regulatory authorities need to consider the relative, rather than the absolute, bargaining position of the client in question.
Outcomes in Children Treated for Perineal Group A Beta-hemolytic Streptococcal Dermatitis

Objectives: To evaluate reports that describe relapse or recurrence following treatment of perineal streptococcal dermatitis (PSD), we studied a large cohort of children with these perianal or perivaginal infections to determine whether outcomes are related to the antimicrobial agent selected for initial treatment. Methods: We audited laboratory logs and medical records to retrospectively identify incident cases of culture-confirmed PSD in children at a large university-affiliated health system during 2006–2008. We estimated rates of recurrence (defined as any return visit with a clinical diagnosis of perineal dermatitis within 6 months) and, then, incorporated these rates into a meta-analysis that included 8 previous studies. Results: A total of 81 children had incident PSD during the study period, and 26 (32.1%) had a recurrence. Most (18/26 [69.2%]) had their first recurrence within 6 weeks. Among children treated with an oral agent, the recurrence rate was 16/42 (38.1%) following penicillin or amoxicillin and 10/36 (27.8%) following a beta-lactamase resistant agent (adjusted odds ratio: 2.02 [95% confidence interval {CI}: 0.69–5.92]). In the meta-analysis, recurrence rates following penicillin or amoxicillin were consistent across studies (fixed-effect test for heterogeneity, P = 0.35), and the pooled rate (37.4% [95% CI: 28.8%–46.5%]) was higher than observed following a beta-lactamase resistant agent (odds ratio: 2.39 [95% CI: 1.18–4.81]). Conclusions: Perineal streptococcal dermatitis initially treated with penicillin or amoxicillin is consistently associated with a high risk of clinical recurrence. Whether treatment with a beta-lactamase resistant agent reduces this risk is uncertain and should be subjected to a clinical trial.
Thermalization properties at mK temperatures of a nanoscale optomechanical resonator with acoustic-bandgap shield

Optical measurements of a nanoscale silicon optomechanical crystal cavity with a mechanical resonance frequency of 3.6 GHz are performed at sub-kelvin temperatures. We infer optical-absorption-induced heating and damping of the mechanical resonator from measurements of phonon occupancy and motional sideband asymmetry. At the lowest probe power and lowest fridge temperature(T_f = 10 mK), the localized mechanical resonance is found to couple at a rate of γ_i/2π = 400 Hz (Q_m = 9 x 10^6) to a thermal bath of temperature T_b ≈ 270 mK. These measurements indicate that silicon optomechanical crystals cooled to millikelvin temperatures should be suitable for a variety of experiments involving coherent coupling between photons and phonons at the single quanta level.
Optimal Contracting for Cattle Feeding: An Assessment of Climatic Conditions

A unique approach using a biophysical growth model from the animal science literature is used to examine optimal contract cattle feeding behavior under alternative climatic conditions. The examination of incentives and outcomes in an unusually comprehensive contract parameter and behavioral space is made possible by combining simulated feedlot and carcass performance of a large set of cattle with public price and weather data. The model uniquely fits typical risk aversion levels and rationalizes existing contract types. The results show that optimal cattle feeding contract varies with climatic condition, but there is a tendency to replace cost-of-gain contracts with yardage-feed contracts as grid pricing has emerged.
The effects of employee training on the relationship between environmental attitude and firms' performance in sustainable development

Should employee training influence firms' performance in sustainable development? Based on research, we predict both direct and moderating effects of employee training on the performance. Assuming the institutional demands in modern societies for environmental protection, we hypothesize that employee training consistent with the demands should have a direct and positive effect on firms' performance in sustainable development. In addition, we also hypothesize that employee training should moderate positively the relationship between a firm's environmental attitude and its performance in sustainable development. Testing our hypotheses among manufacturing firms in both South and North China, we obtain empirical evidence supporting the relationship between a firm's environment attitude and its performance in sustainable development. Moreover, our data show that this relationship can be better understood by taking into account such human resource management practice as employee training. With better employee training, a firm's correct environmental attitude should be more likely to help improve its performance in sustainable development. Moreover, our data also suggest that employee training may also have a positive direct effect on firms' performance in sustainable development.
How useful is thrombocytosis in predicting an underlying cancer in primary care? a systematic review

Background. Although the association between raised platelet count (thrombocytosis) and cancer has been reported in primary and secondary care studies, UK GPs are unaware of it, and it is insufficiently evidenced for laboratories to identify and warn of it. This systematic review aimed to identify and collate evidence from studies that have investigated thrombocytosis as an early marker of cancer in primary care. Methods. EMBASE (OvidSP), Medline (Ovid), Web of Science and The Cochrane Library were searched for relevant studies. Eligible studies had reported estimates of the association between thrombocytosis and cancer, in adults aged ≥40 in a primary care setting. Raw data from included studies were used to calculate positive predictive values and likelihood ratios (LRs) for cancer. Results. Nine case–control studies were identified. Study quality was judged to be high. Included studies reported on the following cancer sites: colorectal, lung, ovary, bladder, kidney, pancreas, oesophago-gastric, uterus and breast. LRs indicated that thrombocytosis was a predictor of cancer in all sites except breast. In a consulting population, thrombocytosis is most highly predictive of lung and colorectal cancer. Conclusions. These results suggest that patients with thrombocytosis in primary care have an increased risk of cancer, and that some, but not all, cancers have raised platelets as an early marker. This finding is expected to be of use in primary care, for GPs receiving blood test results unexpectedly showing high platelet counts. Further research is needed to identify the cancers that are most strongly associated with thrombocytosis.
Identification and cellular localization of the actin‐binding protein ABP‐120 from Entamoeba histolytica

Several actin‐binding proteins participate in the morphological changes that occur during amoeboid movement. The gene encoding one of these proteins, the gelation factor ABP‐120, was identified and characterized from trophozoites of Entamoeba histolytica. The sequence contains 2574 nucleotides, with an open reading frame of 858 amino acids, giving a protein of 93 kDa belonging to the spectrin family. The N‐terminal domain of ABP‐120 from E. histolytica revealed a consensus site for actin binding homologous to the actin‐binding sites of ABP‐120 of Dictyostelium discoideum, α‐actinin and spectrin. Analysis of the central domain revealed the presence of four repeats of a 73‐amino‐acid motif constituting 31% of the protein. In addition, a stretch of 105 amino acids was highly divergent when compared with the C‐terminal domain of D. discoideum ABP‐120. This sequence showed short motifs that are homologous to microtubule‐binding domains. We found that ABP‐120 from E. histolytica binds to F‐actin. In addition, upon motility of the parasite, this protein localized in the pseudopod and the uroid region, implying a role for ABP‐120 in movement and capping of surface receptors in E. histolytica.