Miracle-dz/UniFAR-FTUs huggingface dataset:
Retrospective analysis of the associations and effectiveness of performing therapeutic drug monitoring in pregnant HIV-positive women in two large centres in Manchester

There is no proven benefit for the routine use of therapeutic drug monitoring in HIV-positive pregnant women either for improving viral control or preventing mother-to-child transmission. This analysis reviewed a cohort of 171 HIV-positive pregnant women delivering between 1 January 2008 and 28 May 2013 to first establish which baseline characteristics are associated with having therapeutic drug monitoring performed, and whether therapeutic drug monitoring was associated with improved HIV control during pregnancy or mother-to-child transmission. Therapeutic drug monitoring was performed in 39% (n = 66) of patients; it was associated with baseline characteristics of poor adherence to therapy (therapeutic drug monitoring 23% versus non-therapeutic drug monitoring 10%, p = 0.025) and the use of protease inhibitors (therapeutic drug monitoring 94% versus non-therapeutic drug monitoring 77%, p = 0.005). By multivariate analysis therapeutic drug monitoring was associated with medication alterations during pregnancy (therapeutic drug monitoring 68% versus non-therapeutic drug monitoring 12%, p = < 0.001), but not associated with any difference in viral load breakthrough during pregnancy (therapeutic drug monitoring 12% versus non-therapeutic drug monitoring 7%, p = 0.456) and viral load detectable at birth (therapeutic drug monitoring 14% versus non-therapeutic drug monitoring 9%, p = 0.503). There were no instances of mother-to-child transmission. Therapeutic drug monitoring’s association with medication changes is postulated as partially causal in this cohort. There was no evidence of any association with improved control or reduced transmission of HIV to advocate routine therapeutic drug monitoring use.
Surface‐Grafted Nanogel Arrays Direct Cell Adhesion and Motility

It has long been appreciated that material chemistry and topology profoundly affect cell adhesion and migration. Here, aqueous poly(N‐isopropyl acrylamide) nanogels are designed, synthesized and printed in form of colloidal arrays on glass substrates using wrinkled polydimethylsiloxane templates. Using low‐temperature plasma treatment, nanogels are chemically grafted onto glass supports thus leading to highly stable nanogel layers in cell culture media. Liquid cell atomic force microscopy investigations show that surface‐grafted nanogels retain their swelling behavior in aqueous media and that extracellular matrix protein coating do not alter their stability and topography. It is demonstrated that surface‐grafted nanogels could serve as novel substrates for the analysis of cell adhesion and migration. Nanogels influence size, speed, and dynamics of focal adhesions and cell motility forcing cells to move along highly directional trajectories. Moreover, modulation of nanogel state or spacing serves as an effective tool for regulation of cell motility. It is suggested that nanogel arrays deposited on solid surfaces could be used to provide a precise and tunable system to understand and control cell migration. Additionally, such nanogel arrays will contribute to the development of implantable systems aimed at supporting and enhancing cell migration during, for instance, wound healing and tissue regeneration.
Palmitoylethanolamide Dampens Reactive Astrogliosis and Improves Neuronal Trophic Support in a Triple Transgenic Model of Alzheimer's Disease: In Vitro and In Vivo Evidence

Alzheimer's disease (AD) is a neurodegenerative disorder responsible for the majority of dementia cases in elderly people. It is widely accepted that the main hallmarks of AD are not only senile plaques and neurofibrillary tangles but also reactive astrogliosis, which often precedes detrimental deposits and neuronal atrophy. Such phenomenon facilitates the regeneration of neural networks; however, under some circumstances, like in AD, reactive astrogliosis is detrimental, depriving neurons of the homeostatic support, thus contributing to neuronal loss. We investigated the presence of reactive astrogliosis in 3×Tg-AD mice and the effects of palmitoylethanolamide (PEA), a well-documented anti-inflammatory molecule, by in vitro and in vivo studies. In vitro results revealed a basal reactive state in primary cortical 3×Tg-AD-derived astrocytes and the ability of PEA to counteract such phenomenon and improve viability of 3×Tg-AD-derived neurons. In vivo observations, performed using ultramicronized- (um-) PEA, a formulation endowed with best bioavailability, confirmed the efficacy of this compound. Moreover, the schedule of treatment, mimicking the clinic use (chronic daily administration), revealed its beneficial pharmacological properties in dampening reactive astrogliosis and promoting the glial neurosupportive function. Collectively, our results encourage further investigation on PEA effects, suggesting it as an alternative or adjunct treatment approach for innovative AD therapy.
Maternal immunization: where are we now and how to move forward?

Abstract Pregnancy and the postpartum period are associated with elevated risks to both mother and infant from infectious disease. Vaccination of pregnant women, also called maternal immunization, has the potential to protect pregnant women, foetuses and infants from several vaccine-preventable diseases. Maternal immunoglobulin G antibodies are actively transferred through the placenta to provide passive immunity to new-borns during the first months of life, until the time for infant vaccinations or until the period of greatest susceptibility has passed. Currently, inactivated influenza, tetanus, and pertussis vaccines are recommended during pregnancy in many countries, but other vaccines may also be administered to pregnant women when risk factors are present. Several new vaccines with a specific indication for use during pregnancy are under development (e.g. respiratory syncytial virus and group B streptococcus vaccines). Years of experience suggest that maternal immunization against influenza, tetanus or pertussis has an acceptable safety profile, is well tolerated, effective and confers significant benefits to pregnant women and their infants. This review describes the principles of maternal immunization and provides an update of the recent evidence regarding the use and timing of maternal immunization. Finally, the barriers preventing wider vaccination coverage and the current limitations in addressing these are also described (Supplementary Material). Key messages Maternal immunization gives pregnant women greater protection against infectious diseases; induces high levels of maternal antibodies that can be transferred to the foetus; and helps protect new-borns during their first months of life, until they are old enough to be vaccinated. Pregnant women and new-borns are more vulnerable to infectious diseases than the overall population; nevertheless, vaccination rates are often low in pregnant women. This review provides an update of the recent evidence regarding the use and timing of maternal immunization and describes the barriers preventing wider vaccination uptake and the current limitations in addressing these.
Glucose tolerance before and after renal transplantation.

BACKGROUND Renal insufficiency predisposes to insulin resistance, hyperparathyroidism and derangements in calcium phosphate and nitrogenous compound balance, leading to pre-transplant hyperglycaemia. These metabolic risk factors are not fully corrected after renal transplantation. The present study aimed to assess the role of pre-transplant glycaemia and the named metabolic risk factors in post-transplant hyperglycaemia [PHYG; impaired fasting glucose (IFG), impaired glucose tolerance (IGT) or diabetes mellitus (DM)]. METHODS This is a retrospective cohort study involving 301 patients without pre-transplant DM. Measurements included a pre- and post-transplant oral glucose tolerance test (OGTT) as well as glomerular filtration rate (GFR), parathyroid hormone (PTH), phosphate, calcium and urea measured 10 weeks post-transplant. The risk of PHYG at 10 weeks post-transplant was analysed using multiple logistic regression. RESULTS Ninety-three patients (31%) had PHYG (two IFG, 52 IGT, 39 DM). Variables associated with PHYG included pre-transplant 2-h glycaemia [OR 1.26, 95% CI (1.09, 1.46)] and post-transplant urea levels [OR 1.14, 95% CI (1.02, 1.27)]. Older age, non-Caucasian ethnicity, previous transplants, >or=3 HLA class 1 mismatches and high prednisolone doses were likewise associated with an increased PHYG risk (all P < 0.05). CONCLUSIONS Pre-transplant glycaemia and high post-transplant levels of urea were associated with a greater risk of PHYG. This seemed to be independent of GFR, PTH, phosphate, calcium and traditional risk factors such as age and glucocorticoid load.
High nutritional quality is not associated with low greenhouse gas emissions in self-selected diets of French adults.

BACKGROUND Healthy diets are supposed to be more environmentally friendly because they rely mainly on plant-based foods, which have lower greenhouse gas emissions (GHGEs) per unit weight than do animal-based foods. OBJECTIVES The objectives were to estimate the GHGEs associated with the consumption of self-selected diets in France and to analyze their relation with the nutritional quality of diets. DESIGN For each adult in the national dietary Individual and National Survey on Food Consumption (n = 1918), the GHGEs of his or her diet were estimated based on the GHGEs of 391 foods. Highest-nutritional-quality diets were defined as those having simultaneously 1) an energy density below the median, 2) a mean adequacy ratio (MAR) above the median, and 3) a mean excess ratio (MER, percentage of maximum recommended values for nutrients for which intake should be limited) below the median. RESULTS MAR was positively correlated and MER was negatively correlated with diet-related GHGEs. High-nutritional-quality diets contained more plant-based foods, notably fruit and vegetables, and fewer sweets and salted snacks than did low-quality diets. After adjustment for age, sex, and energy intake, the consumption of sweets and salted snacks was negatively correlated with diet-related GHGEs, whereas the consumption of animal products and of fruit and vegetables was positively associated with them. After adjustment for energy intake, high-nutritional-quality diets had significantly higher GHGEs (+9% and +22% for men and women, respectively) than did low-nutritional-quality diets. CONCLUSION Despite containing large amounts of plant-based foods, self-selected diets of the highest nutritional quality are currently not those with the lowest diet-related GHGEs.
A Dyadic Approach to Pornography Use and Relationship Satisfaction Among Heterosexual Couples: The Role of Pornography Acceptance and Anxious Attachment

The majority of research on pornography use within committed relationships has found such use to be associated with negative outcomes. However, given the variability in pornography use among couples, the current study sought to examine moderators in the association between pornography use and relationship satisfaction in a large sample of heterosexual matched-paired couples (N = 6,626). Actor–partner interdependence models (APIMs) revealed that for men who are more anxiously attached, more pornography use is associated with higher relationship satisfaction; whereas for women who are more anxiously attached, more pornography use is associated with lower relationship satisfaction. For men who are more accepting of pornography, more pornography use is associated with more relationship satisfaction; however, for men who are less accepting of pornography, more pornography use is associated with less relationship satisfaction. There was little difference in relationship satisfaction at differing levels of pornography use for women who are high in pornography acceptance. For women who are low in pornography acceptance, pornography use is associated with less relationship satisfaction. Results are discussed and recommendations for practitioners are made through the lens of symbolic interaction theory.
Changes in the nutritional quality of fast-food items marketed at restaurants, 2010 v. 2013

Abstract Objective To examine the nutritional quality of menu items promoted in four (US) fast-food restaurant chains (McDonald’s, Burger King, Wendy’s, Taco Bell) in 2010 and 2013. Design Menu items pictured on signs and menu boards were recorded at 400 fast-food restaurants across the USA. The Nutrient Profile Index (NPI) was used to calculate overall nutrition scores for items (higher scores indicate greater nutritional quality) and was dichotomized to denote healthier v. less healthy items. Changes over time in NPI scores and energy of promoted foods and beverages were analysed using linear regression. Setting Four hundred fast-food restaurants (McDonald’s, Burger King, Wendy’s, Taco Bell; 100 locations per chain). Subjects NPI of fast-food items marketed at fast-food restaurants. Results Promoted foods and beverages on general menu boards and signs remained below the ‘healthier’ cut-off at both time points. On general menu boards, pictured items became modestly healthier from 2010 to 2013, increasing (mean (se)) by 3·08 (0·16) NPI score points (P<0·001) and decreasing (mean (se)) by 130 (15) kJ (31·1 (3·65) kcal; P<0·001). This pattern was evident in all chains except Taco Bell, where pictured items increased in energy. Foods and beverages pictured on the kids’ section showed the greatest nutritional improvements. Although promoted foods on general menu boards and signs improved in nutritional quality, beverages remained the same or became worse. Conclusions Foods, and to a lesser extent, beverages, promoted on menu boards and signs in fast-food restaurants showed limited improvements in nutritional quality in 2013 v. 2010.
RotationNet: Joint Object Categorization and Pose Estimation Using Multiviews from Unsupervised Viewpoints

We propose a Convolutional Neural Network (CNN)-based model "RotationNet," which takes multi-view images of an object as input and jointly estimates its pose and object category. Unlike previous approaches that use known viewpoint labels for training, our method treats the viewpoint labels as latent variables, which are learned in an unsupervised manner during the training using an unaligned object dataset. RotationNet is designed to use only a partial set of multi-view images for inference, and this property makes it useful in practical scenarios where only partial views are available. Moreover, our pose alignment strategy enables one to obtain view-specific feature representations shared across classes, which is important to maintain high accuracy in both object categorization and pose estimation. Effectiveness of RotationNet is demonstrated by its superior performance to the state-of-the-art methods of 3D object classification on 10- and 40-class ModelNet datasets. We also show that RotationNet, even trained without known poses, achieves the state-of-the-art performance on an object pose estimation dataset.
Identification of a Golgi apparatus protein complex important for the asexual erythrocytic cycle of the malaria parasite Plasmodium falciparum

Compared with other eukaryotic cell types, malaria parasites appear to possess a more rudimentary Golgi apparatus being composed of dispersed, unstacked cis and trans‐cisternae. Despite playing a central role in the secretory pathway of the parasite, few Plasmodium Golgi resident proteins have been characterised. We had previously identified a new Golgi resident protein of unknown function, which we had named Golgi Protein 1, and now show that it forms a complex with a previously uncharacterised transmembrane protein (Golgi Protein 2, GP2). The Golgi Protein complex localises to the cis‐Golgi throughout the erythrocytic cycle and potentially also during the mosquito stages. Analysis of parasite strains where GP1 expression is conditionally repressed and/or the GP2 gene is inactivated reveals that though the Golgi protein complex is not essential at any stage of the parasite life cycle, it is important for optimal asexual development in the blood stages.
Developing and validating test items for first-year computer science courses

We report on the development, validation, and implementation of a collection of test items designed to detect misconceptions related to first-year computer science courses. To this end, we reworked the development scheme proposed by Almstrum et al. (SIGCSE Bulletin 38(4):132–145, 2006) to include students’ artifacts and to simultaneously incorporate think-aloud interviews and flash tests. We also investigated to what extent the practical efficiency of detecting certain misconceptions could be increased without significantly affecting the sensitivity of the instrument, and present positive and negative results regarding this goal. The results of a first transfer and implementation study suggest that it is indeed possible to use the test items in a large-scale practical setting – both as diagnostic instruments and as interventions.
Optic Nerve Head Parameters Measured with Spectral-Domain Optical Coherence Tomography in Healthy Turkish Children: Normal Values, Repeatability, and Interocular Symmetry

ABSTRACT To determine normal values, repeatability, and interocular symmetry of optic nerve head measurements, three spectral-domain optical coherence tomography (SD-OCT) scans were obtained from 128 healthy Turkish children aged 5–17 years consecutively and prospectively. The mean disc area, rim area, cup volume, cup to disc area ratio, and vertical and horizontal cup to disc ratios were 2.30 ± 0.42 mm2, 1.84 ± 0.45 mm2, 0.09 ± 0.10 mm3, 0.20 ± 0.13, 0.37 ± 0.17, and 0.45 ± 0.20, respectively. The intraclass correlation coefficients were >0.9 for repeatability and >0.75 for interocular correlation. Interocular differences were not statistically significant (p > 0.05). Normal paediatric SD-OCT measurements of the optic nerve head are presented, which showed excellent repeatability and no interocular difference.
Black-box Testing of First-Order Logic Ontologies Using WordNet

Artificial Intelligence aims to provide computer programs with commonsense knowledge to reason about our world. This paper offers a new practical approach towards automated commonsense reasoning with first-order logic (FOL) ontologies. We propose a new black-box testing methodology of FOL SUMO-based ontologies by exploiting WordNet and its mapping into SUMO. Our proposal includes a method for the (semi-)automatic creation of a very large benchmark of competency questions and a procedure for its automated evaluation by using automated theorem provers (ATPs). Applying different quality criteria, our testing proposal enables a successful evaluation of a) the competency of several translations of SUMO into FOL and b) the performance of various automated ATPs. Finally, we also provide a fine-grained and complete analysis of the commonsense reasoning competency of current FOL SUMO-based ontologies.
Fast and Accurate Single Image Super-Resolution via Information Distillation Network

Recently, deep convolutional neural networks (CNNs) have been demonstrated remarkable progress on single image super-resolution. However, as the depth and width of the networks increase, CNN-based super-resolution methods have been faced with the challenges of computational complexity and memory consumption in practice. In order to solve the above questions, we propose a deep but compact convolutional network to directly reconstruct the high resolution image from the original low resolution image. In general, the proposed model consists of three parts, which are feature extraction block, stacked information distillation blocks and reconstruction block respectively. By combining an enhancement unit with a compression unit into a distillation block, the local long and short-path features can be effectively extracted. Specifically, the proposed enhancement unit mixes together two different types of features and the compression unit distills more useful information for the sequential blocks. In addition, the proposed network has the advantage of fast execution due to the comparatively few numbers of filters per layer and the use of group convolution. Experimental results demonstrate that the proposed method is superior to the state-of-the-art methods, especially in terms of time performance. Code is available at https://github.com/Zheng222/IDN-Caffe.
Viscous sintering of non-spherical borosilicate-glass powder

Densification by viscous flow - instead of diffusion - may be investigated by comparing densification rates and flow rates without the effect of external load, if possible. This is why the sintering of a borosilicate-glass powder was investigated using a hot-stage microscope. The samples sintered at 888K showed shrinkage anisotropy, being the ratio of the axial to the radial shrinkage <1. The flow rate varies linearly with the densification rate due to anisotropic densification; and the ratio between flow rate and densification rate may be altered by modifying the grade of anisotropy in densification. Scherer's theory has been used to compare experimental and theoretical values and the interdependence between densification rate and density. Deviations are discussed
Increased perceived stress is related to decreased prefrontal cortex volumes among older adults

ABSTRACT Introduction: Several of the brain regions vulnerable to increased levels of stress (i.e., hippocampus and prefrontal cortex) are also known to undergo disproportionate decline during normal aging. To date, surprisingly little research has examined the effects of stress on the brain among healthy human populations, much less in the elderly. The aim of the current study was to investigate the relationship between chronic stress and brain morphometry in regions known for their involvement in the stress response, namely the prefrontal cortex, hippocampus, and amygdala, in a sample of healthy older adults. Method: The Perceived Stress Scale and structural magnetic resonance imaging (MRI) were collected in 28 older adult individuals aged 65 to 90 years. Gray and white matter volumes in various regions of interest in the prefrontal cortex and medial temporal lobes were calculated using semiautomated segmentation tools. Results: Perceived stress was negatively correlated with overall prefrontal cortex (PFC) volume, specifically in overall white matter volume of the PFC. Additionally, perceived stress was negatively correlated with gray and white matter volumes in lateral regions of the PFC, specifically, in the ventrolateral and dorsolateral PFC. Perceived stress was not significantly related to medial temporal lobe volumes. Conclusions: These findings suggest that among healthy older adults, there is a salient relationship between prefrontal cortex volumes and levels of perceived stress. This research fills a critical gap in the current literature and provides initial groundwork for future studies investigating the relationship between perceived stress and the prefrontal cortex in the context of healthy aging.