Miracle-dz/UniFAR-FTUs huggingface dataset:
Concatenate Buying Behavior of Working Women: Empirical Evidence from Islamic Verses Non-Islamic Perspective

Purpose of the study - One is to investigate and compare the buying behavior of Islamic countries i.e. Pakistani and Jordanian working women. Second is to ascertain which dimension of buying behavior is prominent in Pakistani working women vis-a-vis Jordanian working women. Third the study will explore the similarities and differences in buying behavior with-in both populations under study. Finally the study provides comparison of Islamic and Non-Islamic countries working women buying behaviors. Design methodology/approach - A model was developed on the basis of the review of existing literature and tested by collecting data from 310 working women employed in Islamabad and Amman. To establish the reliability, a pilot study was conducted with a sample size of 35 respondents. Correlation analysis and mean scores were used for predicting and explaining the working women buying behaviors in both the countries and were then compared with secondary data of non-Islamic country working women buying behavior, China. Findings - The results of the study reveal that both Pakistani and Jordanian working women are Price, Quality, Brand, Convenience and Time, Environmental and Health, and Personal style conscious. Similarly the working women were also highly Fashion enthusiastic and were receptive to shopping influence from others. However on brand and store loyalty dimensions working women of both Islamic countries differ. The only noticeable difference was that Non-Islamic country working women had variant behaviors on account of Brand, Environmental and Health Consciousness and Fashion Enthusiasm. Research limitation/implication - The results are not genralizable as the data has been collected cross sectionally with limited sample size. The responses were primarily not collected for specific products and the future research explorations must focus on specific products with more varied antecedents. This research employs questionnaire as a data collection tool that has a potential flaw in eliciting intrinsic responses in Islamic countries under study. Practical implications - As working women are more pro-quality and personal style conscious in both Islamic and non Islamic countries, therefore marketers need to devise such strategies that help them to make available such products that will ultimately improve their financial standings. Originality/value - This paper is the only one which is concerned with the shopping styles of both Islamic and Non-Islamic countries working women buying behaviors and their comparisons.
Serotonin transporter-linked polymorphic region (5-HTTLPR) genotype and stressful life events interact to predict preschool-onset depression: a replication and developmental extension.

BACKGROUND Scientific enthusiasm about gene × environment interactions, spurred by the 5-HTTLPR (serotonin transporter-linked polymorphic region) × SLEs (stressful life events) interaction predicting depression, have recently been tempered by sober realizations of small effects and meta-analyses reaching opposing conclusions. These mixed findings highlight the need for further research. Converging evidence suggests that the effects of 5-HTTLPR genotype may be neurodevelopmental in origin, but we are not aware of empirical studies that have investigated whether the 5-HTTLPR genotype × SLE interaction predicts preschool-onset depression (PO-MDD), the earliest validated form of depression. METHODS Children (n = 234) aged 3-5 were recruited for a longitudinal study designed to examine PO-MDD. In a comprehensive baseline assessment, the child's primary caregivers completed questionnaires and were interviewed about their child's behaviors, psychiatric symptoms, and exposure to SLEs. RESULTS A 5-HTTLPR × SLEs interaction emerged, such that children homozygous for the short allele were more susceptible to depression in the context of elevated SLE than long allele carriers. In contrast, at low SLE exposure, short allele homozygotes had fewer depressive symptoms. The data were best fit by a plasticity model with a substantial reduction in fit by diathesis-stress models. CONCLUSIONS Extending studies in adult and adolescent populations, these data suggest that 5-HTTLPR genotype may provide plasticity to environmental influence, for better or worse. Specifically, children homozygous for the short allele were more susceptible to the depressogenic effects of SLEs but benefitted, in the form of reduced depressive symptoms, in the context of relatively benign environmental conditions (i.e. relatively low SLE exposure). These data highlight the importance of examining gene × environment interactions across development, environment, and outcome but should be interpreted cautiously given the small sample size.
Adaptation of Statistical Machine Translation Model for Cross-Lingual Information Retrieval in a Service Context

This work proposes to adapt an existing general SMT model for the task of translating queries that are subsequently going to be used to retrieve information from a target language collection. In the scenario that we focus on access to the document collection itself is not available and changes to the IR model are not possible. We propose two ways to achieve the adaptation effect and both of them are aimed at tuning parameter weights on a set of parallel queries. The first approach is via a standard tuning procedure optimizing for BLEU score and the second one is via a reranking approach optimizing for MAP score. We also extend the second approach by using syntax-based features. Our experiments show improvements of 1-2.5 in terms of MAP score over the retrieval with the non-adapted translation. We show that these improvements are due both to the integration of the adaptation and syntax-features for the query translation task.
MDM2 SNP309 rs2279744 Polymorphism and Gastric Cancer Risk: A Meta-Analysis

Background MDM2 is a major negative regulator of p53, and a single nucleotide polymorphism (SNP) in the MDM2 promoter region SNP309 has been demonstrated to be associated with an increased MDM2 expression and a significantly earlier age of onset of several tumors, including gastric cancer. Several studies were published to evaluate the association between SNP309 and gastric cancer risk. However, the results remain conflicting rather than conclusive. Objective The aim of this study was to assess the association between the MDM2 SNP309 polymorphism and gastric risk. Methods We performed a meta-analysis to investigate this relationship. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of the association. The pooled ORs were performed for codominant model, dominant model, and recessive model, respectively. Results Five published case-control studies, including 1,621 gastric cancer cases and 2,639 controls were identified. We found that the MDM2 SNP309 polymorphism was associated with a significantly increased risk of gastric cancer risk when all studies were pooled into the meta-analysis (GG versus TT, OR = 1.54; 95%CI = 1.04–2.29, and GG versus GT/TT, OR = 1.49, 95%CI = 1.30–1.72). Furthermore, Egger's test did not show any evidence of publication bias (P = 0.799 for GG versus TT). Conclusion Our results suggest that the MDM2 SNP309 polymorphism may be a low-penetrant risk factor for the development of gastric cancer.
Factors Influencing Students' Embedment with, and Embracement of Social Networking Sites: An Analysis

This study investigated the undergraduates’ embedment with, and embracement of social networking sites (SNS) with a modified theory of planned behavior (TPB). It is recognized that social influence, perceived behavioral control, enjoyment, as well as embracement and embedment, are pertinent to the discourse. Data was collected from undergraduates in four (4) culturally diverse countries. Hypotheses were developed to test the proposed research conceptualization. The partial least squares (PLS) technique was used for data analysis. The results confirmed that perceived enjoyment and perceived behavioral control positively influenced students’ behavioral intentions for the use of SNS while subjective norm did not. However, subjective norm has positive impacts on students’ embedment with, and embracement of such tools. Students’ behavioral intention to accept SNS has a positive influence on students’ embedment with, and embracement of SNS.
Ku86 is essential in human somatic cells

Ku86 plays a key role in nonhomologous end joining in mammals. Functional inactivation in rodents of either Ku86 or Ku70, which form the heterodimeric DNA end-binding subunit of the DNA-dependent protein kinase complex, is nevertheless compatible with viability. In contrast, no human patient has been described with mutations in either Ku86 or Ku70. This has led to the hypotheses that either these genes are performing an additional essential role(s) and/or redundant pathways exist that mask the phenotypic expression of these genes when they are mutated in humans. To address this issue, we describe here the construction of human somatic cell lines containing a targeted disruption of the Ku86 locus. Human HCT116 colon cancer cells heterozygous for Ku86 were haploinsufficient with an increase in polyploid cells, a reduction in cell proliferation, elevated p53 levels, and a slight hypersensitivity to ionizing radiation. Functional inactivation of the second Ku86 allele resulted in cells with a drastically reduced doubling time. These cells were capable of undergoing only a limited number of cell divisions, after which they underwent apoptosis. These experiments demonstrate that the Ku86 locus is essential in human somatic tissue culture cells.
How beliefs about self-creation inflate value in the human brain

Humans have a tendency to overvalue their own ideas and creations. Understanding how these errors in judgement emerge is important for explaining suboptimal decisions, as when individuals and groups choose self-created alternatives over superior or equal ones. We show that such overvaluation is a reconstructive process that emerges when participants believe they have created an item, regardless of whether this belief is true or false. This overvaluation is observed both when false beliefs of self-creation are elicited (Experiment 1) or implanted (Experiment 2). Using brain imaging data we highlight the brain processes mediating an interaction between value and belief of self-creation. Specifically, following the creation manipulation there is an increased functional connectivity during valuation between the right caudate nucleus, where we show BOLD activity correlated with subjective value, and the left amygdala, where we show BOLD activity is linked to subjective belief. Our study highlights psychological and neurobiological processes through which false beliefs alter human valuation and in doing so throw light on a common source of error in judgements of value.
Anticipation as exercising (language) motor programs during dreams: A neuropsychoanalytical hypothesis

A neuropsychoanalytically framed hypothesis considering dreams as the ‘motor exercising’ of humans most typical behavior, namely language, is presented. In psychoanalysis dream bizarreness is often resolved by reading the dream content textually. It is defended that this literal interpretation comes down to analyzing language on its articulatory or phonemic structure. While in awake language, lexical (or ego) control is exercised in such a way that scansion of the phoneme structure is operated meaningfully in line with the context, this control is thought not to operate in dreams where it is the motor part (i.e. the articulation) which is thought to be important. The uncontrolled running of these articulatory programs could then result in phonemic ambiguities, thereby accounting for the bizarre elements of the dream.
Incentives and Nutrition for Rotten Kids: Intrahousehold Food Allocation in the Philippines

Using data on individual consumption expenditures from a sample of farm households in the Philippines, we construct a direct test of the risk-sharing implications of the collective household model. We are able to contrast the efficient outcomes predicted by the collective household model with the outcomes we might expect in environments in which food consumption delivers not only utils, but also nutrients which affect future productivity. Finally, we are able to contrast each of these two models with a third, involving a hidden action problem within the household; in this case, the efficient provision of incentives implies that the consumption of each household member depends on their (stochastic) productivity. The efficiency conditions which characterize the within-household allocation of food under the collective household model are violated, as consumption shares respond to earnings shocks. If future productivity depends on current nutrition, then this can explain some but not all of the response, as it appears that the quality of current consumption depends on past earnings. This suggests that some actions taken by household members are private, giving rise to a moral hazard problem within the household.
Effects of Genetic Loci Associated with Central Obesity on Adipocyte Lipolysis

Objectives Numerous genetic loci have been associated with measures of central fat accumulation, such as waist-to-hip ratio adjusted for body mass index (WHRadjBMI). However the mechanisms by which genetic variations influence obesity remain largely elusive. Lipolysis is a key process for regulation of lipid storage in adipocytes, thus is implicated in obesity and its metabolic complications. Here, genetic variants at 36 WHRadjBMI-associated loci were examined for their influence on abdominal subcutaneous adipocyte lipolysis. Subjects and Methods Fasting subcutaneous adipose tissue biopsies were collected from 789 volunteers (587 women and 202 men, body mass index (BMI) range 17.7–62.3 kg/m2). We quantified subcutaneous adipocyte lipolysis, both spontaneous and stimulated by the catecholamine isoprenaline or a cyclic AMP analogue. DNA was extracted from peripheral blood mononuclear cells and genotyping of SNPs associated with WHRadjBMI conducted. The effects on adipocyte lipolysis measures were assessed for SNPs individually and combined in a SNP score. Results The WHRadjBMI-associated loci CMIP, PLXND1, VEGFA and ZNRF3-KREMEN1 demonstrated nominal associations with spontaneous and/or stimulated lipolysis. Candidate genes in these loci have been reported to influence NFκB-signaling, fat cell size and Wnt signalling, all of which may influence lipolysis. Significance This report provides evidence for specific WHRadjBMI-associated loci as candidates to modulate adipocyte lipolysis. Additionally, our data suggests that genetically increased central fat accumulation is unlikely to be a major cause of altered lipolysis in abdominal adipocytes.
Integrated all-pass filters for tunable dispersion and dispersion slope compensation

New integrated optical all-pass filters are presented that can be used for tunable dispersion compensation, dispersion slope compensation, and as building blocks in tunable bandpass filters. The dispersion slope compensation capability is demonstrated using ring resonators in /spl Delta/=2% Ge-doped silica planar waveguides. In addition, a tunable four-stage filter with free-spectral range (FSR)=25 GHz, a passband width of 14 GHz (0.56/spl times/FSR), and D=1800 ps/nm is reported.
Perfluorooctanoic Acid for Shotgun Proteomics

Here, we describe the novel use of a volatile surfactant, perfluorooctanoic acid (PFOA), for shotgun proteomics. PFOA was found to solubilize membrane proteins as effectively as sodium dodecyl sulfate (SDS). PFOA concentrations up to 0.5% (w/v) did not significantly inhibit trypsin activity. The unique features of PFOA allowed us to develop a single-tube shotgun proteomics method that used all volatile chemicals that could easily be removed by evaporation prior to mass spectrometry analysis. The experimental procedures involved: 1) extraction of proteins in 2% PFOA; 2) reduction of cystine residues with triethyl phosphine and their S-alkylation with iodoethanol; 3) trypsin digestion of proteins in 0.5% PFOA; 4) removal of PFOA by evaporation; and 5) LC-MS/MS analysis of the resulting peptides. The general applicability of the method was demonstrated with the membrane preparation of photoreceptor outer segments. We identified 75 proteins from 1 µg of the tryptic peptides in a single, 1-hour, LC-MS/MS run. About 67% of the proteins identified were classified as membrane proteins. We also demonstrate that a proteolytic 18O labeling procedure can be incorporated after the PFOA removal step for quantitative proteomic experiments. The present method does not require sample clean-up devices such as solid-phase extractions and membrane filters, so no proteins/peptides are lost in any experimental steps. Thus, this single-tube shotgun proteomics method overcomes the major drawbacks of surfactant use in proteomic experiments.
Expansion of somatically reverted memory CD8+ T cells in patients with X-linked lymphoproliferative disease caused by selective pressure from Epstein-Barr virus

In patients with XLP, a primary immunodeficiency caused by mutations in SH2D1A, EBV infection can lead to somatic reversion of the disease-causing mutation selectively in effector memory CD8 T cells; reverted CD8 cells are better able to respond to and kill EBV-infected cells.
Semantic and phonological activation electrified: Brain electrophysiological correlates of masked picture priming in fluent and stuttering adults

iv Introduction . 1 Language Processing During Speech Production . 3 Current Evidence of Linguistic Processing in AWS . 6 Brain Electrophysiological Techniques for Studying Linguistic Processing During Speech Production . 7 Summary and Research Question . 13 Method . 15 Participants . 15 Stimuli . 16 Procedure . 17 Apparatus and Recording . 17 EEG-to-Average ERP Data Reduction. 18 Analysis . 19 Behavioral data . 19 ERP data . 19 Results . 22 Behavioral Data . 22 Naming accuracy . 22 Naming reaction time . 22 ERP Data . 22 T380 effects . 23 T516 effects . 24 Discussion . 26 Observed ERP Priming Effects . 26 Clinical Implications . 30 Lexical-semantic enrichment . 30 Attentional enhancement . 32 Reduction of verbal accessories . 35 Summary and Conclusions . 35 References . 44
Education of teachers: the English experience

This article considers the impact of recent political decisions on the provision of teacher education and the continuing development of teachers in England. It tracks how successive governments have changed the requirements necessary to become a teacher as circumstances have changed in the country and considers the impact of these changes on higher education institutions. It considers the range of ways in which someone might now become a teacher and the various providers that might become involved in this process. The recent coalition government’s use of the term ‘initial teacher training’ is used as means of identifying how the views of this government differ from others that use the term ‘initial teacher education’ and what this means to both teachers and universities.
Influence of three coccidiostats on the pharmacokinetics of florfenicol in rabbits

In-feed Medication has been used for a long time to prevent coccidiosis, a worldwide protozoal disease in rabbits. Florfenicol (FFC) has been widely used in veterinary clinics for bacterial diseases treatment. Therefore, the use of combinations of coccidiostats with FFC in rabbits is common. In the present study, we aimed to evaluate the effect of three coccidiostats, sulfaquinoxaline (SUL), robenidine (ROB), and toltrazuril (TOL), as feed additives on the pharmacokinetic profile of FFC in rabbits. The disposition kinetics of FFC in rabbits were investigated after a single intravenous injection (25 mg/kg) in rabbits fed anticoccidial-free diets or feeds containing SUL (250 ppm), ROB (66 ppm), or TOL (2 ppm), respectively, for 20 days. Plasma FFC concentrations were determined by the high performance liquid chromatography (HPLC) method. The pharmacokinetic parameters of FFC were analyzed using a non-compartmental analysis based on the statistical moment theory. The results demonstrated that ROB feeding resulted in an obvious decrease in plasma FFC level as compared with anticoccidial-free feeding. The terminal elimination half-life (t1/2z), area under the concentration–time curve (AUC), area under the first moment curve (AUMC), and mean residence time (MRT) significantly decreased, whereas the elimination rate constant (λz) and total body clearance (CLz) obviously increased in rabbits pretreated with ROB. However, we did not find that SUL or TOL feeding had any effect on the pharmacokinetic profile of FFC. Our findings suggested that more attention should be paid to the use of FFC in rabbits supplemented with ROB.
THE CONSTRUCT VALIDITY OF THE MMPI-2/MMPI-2-RF RESTRUCTURED CLINICAL (RC) SCALES AND THE ASSESSMENT OF PERSONALITY DISORDERS

The current study examined the construct validity of the Restructured Clinical (RC) scales (Tellegen et al., 2003) of the Minnesota Multiphasic Personality Inventory-2 (MMPI-2; Butcher, Dahlstrom, Graham, Tellegen, & Kaemmer, 1989) and MMPI-2-Restructured Form (MMPI-2-RF; Ben-Porath & Tellegen, 2008) and the assessment of personality disorders. Tellegen et al. (2003) constructed the RC scales to address the perceived psychometric limitations of the Clinical scales and to measure the core psychological constructs of each of the Clinical scales whilst enhancing convergent and particularly discriminant validity. Tellegen et al.'s project resulted in the development of nine RC scales that were designed to be independent of the pervasive influence of the first factor, more distinctive and a more accurate measure of the core psychological constructs the original Clinical scales were designed to measure. This study utilised a forensic sample (n = 83) in order to analyse the construct validity of the RC scales when compared to the Structured Clinical Interview for the fourth edition of the DSM (DSM-IV; APA, 1994) Axis II Disorders-Personality Questionnaire (SCID-II PQ; First, Gibbon, Spitzer, Williams & Benjamin, 1997) and the Revised NEO Personality Inventory (NEO-PI-R; Costa & McCrae, 1992). The findings for this study demonstrated the construct validity of the RC scales when compared to the SCID-II PQ personality disorder raw scores and the NEO-PI-R domain and facet scales. The RC scales also accounted for additional variance over the NEO-PI-R domain scales for 8 out of the 10 SCID-II PQ personality disorder raw scores and provided a clinically accurate profile of personality disorders when expressed in their more pathological variants in a forensic population. The findings provide strong support for the construct validity of the MMPI-2/MMPI-2-RF RC scales and the assessment of personality disorders in a forensic setting. The results also support the aims of Tellegen et al. to create a set of scales that accurately measure the core psychological constructs of the Clinical scales whilst enhancing convergent and discriminant validity.