Miracle-dz/UniFAR-FTUs huggingface dataset:
Multicenter Observational Study of the First-Generation Intravenous Blood Glucose Monitoring System in Hospitalized Patients

Background: Current methods of blood glucose (BG) monitoring and insulin delivery are labor intensive and commonly fail to achieve the desired level of BG control. There is great clinical need in the hospital for a user-friendly bedside device that can automatically monitor the concentration of BG safely, accurately, frequently, and reliably. Methods: A 100-patient observation study was conducted at 6 US hospitals to evaluate the first generation of the Intravenous Blood Glucose (IVBG) System (Edwards Lifesciences LLC & Dexcom Inc). Device safety, accuracy, and reliability were assessed. A research nurse sampled blood from a vascular catheter every 4 hours for ≤ 72 hours and BG concentration was measured using the YSI 2300 STAT Plus Analyzer (YSI Life Sciences). The IVBG measurements were compared to YSI measurements to calculate point accuracy. Results: The IVBG systems logged more than 5500 hours of operation in 100 critical care patients without causing infection or inflammation of a vein. A total of 44135 IVBG measurements were performed in 100 patients with 30231 measurements from the subset of 75 patients used for accuracy analysis. In all, 996 IVBG measurements were time-matched with reference YSI measurements. These pairs had a mean absolute difference (MAD) of 11.61 mg/dl, a mean absolute relative difference (MARD) of 8.23%, 93% met 15/20% accuracy defined by International Organization for Standardization 15197:2003 standard, and 93.2% were in zone A of the Clarke error grid. The IVBG sensors were exposed to more than 200 different medications with no observable effect on accuracy. Conclusions: The IVBG system is an automated and user-friendly glucose monitoring system that provides accurate and frequent BG measurements with great potential to improve the safety and efficacy of insulin therapy and BG control in the hospital, potentially leading to improved clinical outcomes.
Information Technology in the Learning Economy: Challenges for Developing Countries

This paper inquires how the concept of the "learning economy" can be applied to the requirements of developing countries. The main purpose is to develop an analytical framework to better understand how learning and capability formation can foster industrial upgrading. Special emphasis is given to te spread of information technology (IT). We inquire under what conditions developing countries can use this set of generic technologies to improve their learning capabilities. We argue that information technology should not be regarded as a potential substitute for human skills and tacit knowledge. Instead, its main role should be to support the formation and use of tacit knowledge. In the paper we compare two stylised models of the learning economy, the Japanese versus the American model. The Japanese model is explicit in its promotion and exploitation of tacit knowledge, while the American model is driven by a permanent urge to reduce the importance of tacit knowledge and to transform it into information - that is into explicit, 4 well structured and codified knowledge. We show that each of these models has peculiar strengths and weaknesses. Developing countries need to develop their own hybrid forms of institutions that combine the advantages of both models in a way that is appropriate to their idiosyncratic needs and capabilities.
Spatial variations of nitrogen trace gas emissions from tropical mountain forests in Nyungwe, Rwanda

Abstract. Globally, tropical forest soils represent the second largest source of N2O and NO. However, there is still considerable uncertainty on the spatial variability and soil properties controlling N trace gas emission. Therefore, we carried out an incubation experiment with soils from 31 locations in the Nyungwe tropical mountain forest in southwestern Rwanda. All soils were incubated at three different moisture levels (50, 70 and 90 % water filled pore space (WFPS)) at 17 °C. Nitrous oxide emission varied between 4.5 and 400 μg N m−2 h−1, while NO emission varied from 6.6 to 265 μg N m−2 h−1. Mean N2O emission at different moisture levels was 46.5 ± 11.1 (50 %WFPS), 71.7 ± 11.5 (70 %WFPS) and 98.8 ± 16.4 (90 %WFPS) μg N m−2 h−1, while mean NO emission was 69.3 ± 9.3 (50 %WFPS), 47.1 ± 5.8 (70 %WFPS) and 36.1 ± 4.2 (90 %WFPS) μg N m−2 h−1. The latter suggests that climate (i.e. dry vs. wet season) controls N2O and NO emissions. Positive correlations with soil carbon and nitrogen indicate a biological control over N2O and NO production. But interestingly N2O and NO emissions also showed a positive correlation with free iron and a negative correlation with soil pH (only N2O). The latter suggest that chemo-denitrification might, at least for N2O, be an important production pathway. In conclusion improved understanding and process based modeling of N trace gas emission from tropical forests will benefit from spatially explicit trace gas emission estimates linked to basic soil property data and differentiating between biological and chemical pathways for N trace gas formation.
Optical generation of amplitude-equalized pulses from a rational harmonic mode-locked fiber laser incorporating an SOA loop modulator

Rational harmonic active and passive mode locking has been demonstrated in an erbium-doped fiber laser using an all-optical approach. Based on the modulation and the self-switching effects of a semiconductor optical amplifier nonlinear loop mirror, hybrid mode locking and pulse-amplitude equalization are simultaneously achieved in the laser. In our setup, amplitude-equalized pulse trains up to about 12 GHz are obtained at 1.55 /spl mu/m using 3-GHz optical driving pulses.
Prognostic Significance of Small-Artery Structure in Hypertension

Background—The presence of structural alterations in the microcirculation may be considered an important mechanism of organ damage; however, it is not currently known whether structural alterations of small arteries may predict fatal and nonfatal cardiovascular events. Methods and Results—One hundred twenty-eight patients were included in the present study. There were 59 patients with essential hypertension, 17 with pheochromocytoma, 20 with primary aldosteronism, 12 with renovascular hypertension, and 20 normotensive patients with non-insulin-dependent diabetes mellitus. All subjects were submitted to a biopsy of subcutaneous fat. Small resistance arteries were dissected and mounted on an isometric myograph, and the tunica media-to-internal lumen ratio (M/L) was measured. The subjects were reevaluated after an average follow-up time of 5.4 years. Thirty-seven subjects had a documented fatal or nonfatal cardiovascular event (5.32 events/100 patients per year). In the subcutaneous small arteries of subjects with cardiovascular events, a smaller internal diameter and a clearly greater M/L was observed. Our subjects were subdivided according to the presence of an M/L greater or smaller than the mean and median values observed in the whole population (0.098) or mean value +2 SD of our normal subjects (0.11). Life-table analyses showed a significant difference in event-free survival between the subgroups. Cox’s proportional hazard model, considering all known cardiovascular risk factors, indicated that only pulse pressure (P =0.009) and M/L (P <0.0001) were significantly associated with the occurrence of cardiovascular events. Conclusions—Our results strongly indicate a relevant prognostic role of structural alterations in small resistance arteries of a high-risk population.
Predicting Project Outcome Leveraging Socio-Technical Network Patterns

There are many software projects started daily, some are successful, while others are not. Successful projects get completed, are used by many people, and bring benefits to users. Failed projects do not bring similar benefits. In this work, we are interested in developing an effective machine learning solution that predicts project outcome (i.e., success or failures) from developer socio-technical network. To do so, we investigate successful and failed projects to find factors that differentiate the two. We analyze the socio-technical aspect of the software development process by focusing at the people that contribute to these projects and the interactions among them. We first form a collaboration graph for each software project. We then create a training set consisting of two graph databases corresponding to successful and failed projects respectively. A new data mining approach is then employed to extract discriminative rich patterns that appear frequently on the successful projects but rarely on the failed projects. We find that these automatically mined patterns are effective features to predict project outcomes. We experiment our solution on projects in Source Forge. Net, the largest open source software development portal, and show that under 10 fold cross validation, our approach could achieve an accuracy of more than 90% and an AUC score of 0.86. We also present and analyze some mined socio-technical patterns.
Some implications of psychotherapy research for therapeutic practice.

A survey of psychotherapy research findings is digested into 6 broad conclusions, and implications for practice and research are drawn from them. They are: (a) Psychotherapy causes clients to become better or worse adjusted than controls, (b) Control Ss improve with time as a result of informal therapeutic encounters, (c) Therapeutic progress varies with therapist warmth, empathy, adjustment, and experience, (d) Client-centered therapy is the only interview-oriented method that has been validated by research, (e) Traditional therapies are seriously limited in effectiveness and are relevant for a small minority of disturbances, and (f) Behavior therapies have considerable promise for enhancing therapeutic effectiveness and should be utilized or experimented with more widely.
What Promotes Wisdom in 12-Step Recovery?

Research investigations on 12-step groups such as Alcoholics Anonymous (AA) and Narcotics Anonymous (NA) have addressed a number of resources associated with 12-step recovery. However, little is known about the role of wisdom and whether aspects of 12-step participation might increase this resource among 12-step members. An exploratory analysis revealed that participants who reported having a “spiritual awakening” and considered themselves “members” of 12-step groups reported significantly higher levels of wisdom. Twelve-step meeting attendance was not significantly related to wisdom scores. Findings suggest certain aspects of 12-step involvement are associated with wisdom and may play a role in substance abuse recovery.
The Propeptide of the Metalloprotease of Listeria monocytogenes Controls Compartmentalization of the Zymogen during Intracellular Infection

ABSTRACT Integral to the virulence of the intracellular bacterial pathogen Listeria monocytogenes is its metalloprotease (Mpl). Mpl regulates the activity and compartmentalization of the bacterial broad-range phospholipase C (PC-PLC). Mpl is secreted as a proprotein that undergoes intramolecular autocatalysis to release its catalytic domain. In related proteases, the propeptide serves as a folding catalyst and can act either in cis or in trans. Propeptides can also influence protein compartmentalization and intracellular trafficking or decrease folding kinetics. In this study, we aimed to determine the role of the Mpl propeptide by monitoring the behavior of Mpl synthesized in the absence of its propeptide (MplΔpro) and of two Mpl single-site mutants with unstable propeptides: Mpl(H75V) and Mpl(H95L). We observed that all three Mpl mutants mediate PC-PLC activation when bacteria are grown on semisolid medium, but to a lesser extent than wild-type Mpl, indicating that, although not essential, the propeptide enhances the production of active Mpl. However, the mutant proteins were not functional in infected cells, as determined by monitoring PC-PLC maturation and compartmentalization. This defect could not be rescued by providing the propeptide in trans to the mplΔpro mutant. We tested the compartmentalization of Mpl during intracellular infection and observed that the mutant Mpl species were aberrantly secreted in the cytosol of infected cells. These data indicated that the propeptide of Mpl serves to maintain bacterium-associated Mpl and that this localization is essential to the function of Mpl during intracellular infection.
Statistical significance in psychological research.

Most theories in the areas of personality, clinical, and social psychology predict no more than the direction of a correlation, group difference, or treatment effect. Since the null hypothesis is never strictly true, such predictions have about a SO-SO chance of being confirmed by experiment when the theory in question is false, since the statistical significance of the result is a function of the sample size. Confirmation of a single directional prediction should usually add little to one's confidence in the theory being tested. Most theories should be tested by multiple corroboration and most empirical generalizations by constructive replication. Statistical significance is perhaps the least important attribute of a good experiment; it is never a sufficient condition for claiming that a theory has been usefully corroborated, that a meaningful empirical fact has been established, or that an experimental report ought to be published. In a recent journal article Sapolsky (1964) developed the following substantive theory: Some psychiatric patients entertain an unconscious belief in the "cloacal theory of birth" which involves the notions of oral impregnation and anal parturition. Such patients should be inclined to manifest eating disorders: compulsive eating in the case of those who wish to get pregnant and anorexia in those who do not. Such patients should also be inclined to see cloacal animals, such as frogs, on the Rorschach. This reasoning led Sapolsky to predict that Rorschach frog responders show
Enabling Effective Operational Risk Management in a Financial Institution: An Action Research Study

Abstract Action research (AR) is significant for its promise to bridge the chasm between rigor and relevance by seeking to solve real-world problems while building scientific knowledge. In this spirit, in our research project, we argue for a return to the essence of AR—that is, focusing on problem, action, and reflection. Adopting the style of AR known as dialogical AR, we address the issue of operational risk management as encountered by a financial institution in Taiwan. In this AR project, the researchers work collaboratively with workers in a bank to manage the knowledge creation process as part of an operational risk management program. Through three AR cycles, our findings demonstrate that ongoing knowledge creation facilitates the transformation of existing organizational culture and helps practitioners to identify different types of operational risks. We also highlight the conditions under which insights from reflective dialogues between practitioners and researchers can encourage managers to open themselves to new and different ways of thinking and acting. Finally, we offer principles for undertaking effective dialogical AR.
Consistent surface color for texturing large objects in outdoor scenes

Color appearance of an object is significantly influenced by the color of the illumination. When the illumination color changes, the color appearance of the object change accordingly, causing its appearance to be inconsistent. To arrive at color constancy, we have developed a physics-based method of estimating and removing the illumination color. In this paper, we focus on the use of this method to deal with outdoor scenes, since very few physics-based methods have successfully handled outdoor color constancy. Our method is principally based on shadowed and non-shadowed regions. Previously researchers have discovered that shadowed regions are illuminated by sky light, while non-shadowed regions are illuminated by a combination of sky light and sunlight. Based on this difference of illumination, we estimate the illumination colors (both the sunlight and the sky light) and then remove them. To reliably estimate the illumination colors in outdoor scenes, we include the analysis of noise, since the presence of noise is inevitable in natural images. As a result, compared to existing methods, the proposed method is more effective and robust in handling outdoor scenes. In addition, the proposed method requires only a single input image, making it useful for many applications of computer vision
Effects of a 21-day expedition to 6,194 m on human skeletal muscle SR Ca2+-ATPase.

We investigated the effects of a 21-day expedition to the summit of Mount Denali, Alaska (6,194 m) on selected Ca2+ sequestration properties of sarcoplasmic reticulum (SR) calcium pump in vastus lateralis muscle. Muscle samples were obtained by biopsy from 5 male climbers (peak oxygen consumption, VO2peak = 52.3 +/- 2.1 mL.kg(-1). min(-1)) approximately 7 days prior to (PRE) and 4 days following (POST) the expedition. A comparison of PRE versus POST measures of maximal Ca2+-ATPase activities (117 +/- 8.5 vs. 97.6 +/- 5.6 nmol.mg protein(-1). min(-1)) and Ca2+-uptake (204 +/- 15 vs. 161 +/- 11 nmol.mg protein(-1). min(-1)) measured in crude homogenates obtained from pre-exercised muscle, indicated only an effect (p < 0.05) of the expedition on Ca2+-uptake. The reduction in Ca2+-ATPase activity, representing 16.6%, was not significant (p = 0.089). The sarco endoplasmic reticulum calcium (SERCA)-ATPase isoforms, measured using Western blotting techniques, revealed a small reduction (p < 0.05) in SERCA 1 (-4.6 +/- 1.9%), but not in SERCA 2a (+2.0 +/- 1.4%). Prior to the expedition, both Ca2+-ATPase activity and Ca2+-uptake were reduced (p < 0.05) by approximately 34 and 18%, respectively, following 40 min of a two-step continuous cycling task (20 min at 59% VO2peak and 20 min at 74% VO2peak). The exercise-induced reduction in Ca2+-ATPase activity was independent of fiber type. Only in the case of Ca2+-uptake was a lower exercise response (p < 0.05) observed following the expedition, an effect that was due to the lower resting value. It is concluded that acclimatization as experienced during a mountaineering expedition induces changes in the properties of the SR Ca2+-pump, and particularly to Ca2+-sequestering function.
ISOLATION, SCREENING AND PARTIAL PURIFICATION OF CELLULASE FROM CELLULASE PRODUCING BACTERIA

The cellulase producing bacteria was isolated from cow dung and characterized by morphological and biochemical analysis. Further partial purification of cellulase was carried out by dialysis and ammonium phosphate precipitation and also to determine molecular weight by SDS-PAGE. Bacterial isolated were grown on Carboxy Methyl Cellulose (CMC) agar at various optimum conditions such as parameters like pH, temperature, incubation period, carbon and nitrogen sources prior to examined and identified primarily as genus, Bacillus species for cellulase production by morphological and biochemical analysis. Optimized conditions of CMC and Coir waste as substrates were Glucose, Yeast extract of pH-6 at 40oC for 48 hour but saw dust as substrate has optimized pH-7 with Xylose, Yeast extract at 50oC for 48 hours. Among three substrates used, Carboxy Methyl Cellulose was found to be the best substrate for cellulase production, when compared to coir waste and saw dust as substrates. This is due to the less complexity and hence easy assimilation of Carboxy Methyl Cellulose by the isolated microbe. Ammonium sulphate precipitation followed by dialysis was performed to partially purify the cellulase enzyme. The molecular weight was found to be 32.5 kilodaltons by SDS-PAGE method. On performing zymogram staining, the cellulolytic property was confirmed. The use of microorganisms for the production of enzymes offers a promising approach for its large
Antianginal Efficacy of Ivabradine in Patients With History of Coronary Revascularization

Although coronary revascularization procedures are widely performed in patients with coronary artery disease (CAD), angina is often reported, even after such procedures. This study evaluated the antianginal efficacy and effect of ivabradine treatment on quality of life (QOL) in patients with CAD and history of coronary revascularization. This is a post hoc analysis (926 post-revascularization patients) of a prospective, noninterventional study, which included 2403 patients with CAD and stable angina. The data were recorded at baseline, at 1 month and 4 months after inclusion. After ivabradine administration, mean number of anginal events decreased from 2.2 ± 2.3 (median: 2.0, minimum: 0.0, maximum: 21.0, range: 21.0) to 0.3 ± 0.6 (median: 0.0, minimum: 0.0, maximum: 7.0, range: 7.0) times/week (P < .001), while nitroglycerin consumption decreased from 1.5 ± 2.2 (median: 1.0, minimum: 0.0, maximum: 20.0, range: 20.0) to 0.1 ± 0.4 times/week (median: 0.0, minimum: 0.0, maximum: 5.0, range: 5.0; P < .001). Quality of life improved at study completion compared to baseline (P < .001). Ivabradine addition on top of optimal individualized dose of β-blockers is associated with decreased anginal events and improvement in QOL in patients with stable angina and history of coronary revascularization.
Early Results of Three-Year Monitoring of Red Wood Ants’ Behavioral Changes and Their Possible Correlation with Earthquake Events

Simple Summary For three years (2009–2012), two red wood ant mounds (Formica rufa-group), located at the seismically active Neuwied Basin (Eifel, Germany), have been monitored 24/7 by high-resolution cameras. Early results show that ants have a well-identifiable standard daily routine. Correlation with local seismic events suggests changes in the ants’ behavior hours before the earthquake: the nocturnal rest phase and daily activity are suppressed, and standard daily routine does not resume until the next day. At present, an automated image evaluation routine is being applied to the video streams. Based on this automated approach, a statistical analysis of the ant behavior will be carried out. Abstract Short-term earthquake predictions with an advance warning of several hours or days are currently not possible due to both incomplete understanding of the complex tectonic processes and inadequate observations. Abnormal animal behaviors before earthquakes have been reported previously, but create problems in monitoring and reliability. The situation is different with red wood ants (RWA; Formica rufa-group (Hymenoptera: Formicidae)). They have stationary mounds on tectonically active, gas-bearing fault systems. These faults may be potential earthquake areas. For three years (2009–2012), two red wood ant mounds (Formica rufa-group), located at the seismically active Neuwied Basin (Eifel, Germany), have been monitored 24/7 by high-resolution cameras with both a color and an infrared sensor. Early results show that ants have a well-identifiable standard daily routine. Correlation with local seismic events suggests changes in the ants’ behavior hours before the earthquake: the nocturnal rest phase and daily activity are suppressed, and standard daily routine does not resume until the next day. At present, an automated image evaluation routine is being applied to the more than 45,000 hours of video streams. Based on this automated approach, a statistical analysis of the ants’ behavior will be carried out. In addition, other parameters (climate, geotectonic and biological), which may influence behavior, will be included in the analysis.