Miracle-dz/UniFAR-FTUs huggingface dataset:
A lower bound for the density of states of the lattice Anderson model

We consider the Anderson model on the multi-dimensional cubic lattice and prove a positive lower bound on the density of states under certain conditions. For example, if the random variables are independently and identically distributed and the probability measure has a bounded Lebesgue density with compact support, and if this density is essentially bounded away from zero on its support, then we prove that the density of states is strictly positive for Lebesgue-almost every energy in the deterministic spectrum.
Highly (111) Textured Copper Foils with High Hardness and High Electrical Conductivity by Pulse Reverse Electrodeposition

The present article reports the pulse reverse electrodeposition of highly (111) textured freestanding copper foils, in an additive-free electrolyte, exhibiting hardness as high as 2.2―2.7 GPa with an electrical conductivity equal to that of bulk copper. The short anodic pulse applied and the absence of organic additives allowed the formation of highly dense foils with room-temperature stability in terms of mechanical and electrical properties. The process involves a fast electrodeposition method with a deposition rate of 25―50 μm/h. The (111) texture and twin boundaries contribute to the high hardness and better electrical conductivity of the copper foils.
Impact of Arts Participation on Health Outcomes for Older Adults

The objective of this study was to present findings from a literature review on the documented health benefits of arts programs for older adults. A systematic literature review was conducted to examine research publications on participatory arts programs for older adults and their reported impact on health outcomes. A total of 2,205 articles were found. Of these, 11 were eligible for inclusion. The review describes the effects of participation in art programs on a variety of health outcomes. The small number of empirical studies documenting the health impact and limitations in their design prohibit broad generalizations, however, findings suggest there are physical and mental health benefits for older adults from arts participation.
Disruption of TTDA Results in Complete Nucleotide Excision Repair Deficiency and Embryonic Lethality

The ten-subunit transcription factor IIH (TFIIH) plays a crucial role in transcription and nucleotide excision repair (NER). Inactivating mutations in the smallest 8-kDa TFB5/TTDA subunit cause the neurodevelopmental progeroid repair syndrome trichothiodystrophy A (TTD-A). Previous studies have shown that TTDA is the only TFIIH subunit that appears not to be essential for NER, transcription, or viability. We studied the consequences of TTDA inactivation by generating a Ttda knock-out (Ttda−/−) mouse-model resembling TTD-A patients. Unexpectedly, Ttda−/− mice were embryonic lethal. However, in contrast to full disruption of all other TFIIH subunits, viability of Ttda−/− cells was not affected. Surprisingly, Ttda−/− cells were completely NER deficient, contrary to the incomplete NER deficiency of TTD-A patient-derived cells. We further showed that TTD-A patient mutations only partially inactivate TTDA function, explaining the relatively mild repair phenotype of TTD-A cells. Moreover, Ttda−/− cells were also highly sensitive to oxidizing agents. These findings reveal an essential role of TTDA for life, nucleotide excision repair, and oxidative DNA damage repair and identify Ttda−/− cells as a unique class of TFIIH mutants.
Laurentian Great Lakes Phytoplankton and Their Water Quality Characteristics, Including a Diatom-Based Model for Paleoreconstruction of Phosphorus

Recent shifts in water quality and food web characteristics driven by anthropogenic impacts on the Laurentian Great Lakes warranted an examination of pelagic primary producers as tracers of environmental change. The distributions of the 263 common phytoplankton taxa were related to water quality variables to determine taxon-specific responses that may be useful in indicator models. A detailed checklist of taxa and their environmental optima are provided. Multivariate analyses indicated a strong relationship between total phosphorus (TP) and patterns in the diatom assemblages across the Great Lakes. Of the 118 common diatom taxa, 90 (76%) had a directional response along the TP gradient. We further evaluated a diatom-based transfer function for TP based on the weighted-average abundance of taxa, assuming unimodal distributions along the TP gradient. The r2 between observed and inferred TP in the training dataset was 0.79. Substantial spatial and environmental autocorrelation within the training set of samples justified the need for further model validation. A randomization procedure indicated that the actual transfer function consistently performed better than functions based on reshuffled environmental data. Further, TP was minimally confounded by other environmental variables, as indicated by the relatively large amount of unique variance in the diatoms explained by TP. We demonstrated the effectiveness of the transfer function by hindcasting TP concentrations using fossil diatom assemblages in a Lake Superior sediment core. Passive, multivariate analysis of the fossil samples against the training set indicated that phosphorus was a strong determinant of historical diatom assemblages, verifying that the transfer function was suited to reconstruct past TP in Lake Superior. Collectively, these results showed that phytoplankton coefficients for water quality can be robust indicators of Great Lakes pelagic condition. The diatom-based transfer function can be used in lake management when retrospective data are needed for tracking long-term degradation, remediation and trajectories.
One-hour postload plasma glucose levels are associated with kidney dysfunction.

BACKGROUND AND OBJECTIVES A cutoff of 155 mg/dl for 1-hour postload plasma glucose (1hPG) during the oral glucose tolerance test (OGTT) is able to identify patients who are at high risk for type 2 diabetes and vascular atherosclerosis. We aimed to examine whether individuals with 1hPG ≥155 mg/dl are also at increased risk for chronic kidney disease (CKD). DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS Atherosclerosis risk factors, OGTT, and estimated GFR by Chronic Kidney Disease Epidemiology Collaboration equation were analyzed in 1075 white individuals without diabetes. RESULTS The area under the receiver operating characteristic curve for 1hPG was the highest (0.700) compared with the areas under the receiver operating characteristic curve of 0, 30-minute, and 2-hour glucose concentrations. Individuals with 1hPG ≥155 mg/dl had a worse cardiometabolic risk profile, exhibiting significantly higher body mass index, BP, triglycerides, and fasting insulin levels and lower HDL, IGF-1 levels, and insulin sensitivity, than individuals with 1hPG <155 mg/dl. Estimated GFR was significantly lower in individuals with 1hPG ≥155 mg/dl. In a logistic regression model adjusted for age and gender, individuals with 1hPG ≥155 mg/dl showed an increased risk for CKD compared with individuals with 1hPG <155 mg/dl. When the logistic regression analysis was restricted to individuals who had normal glucose tolerance, those with 1hPG ≥155 mg/dl showed a higher risk for CKD compared with individuals with 1hPG <155 mg/dl. CONCLUSIONS These data suggest that a cutoff point of 155 mg/dl for the 1hPG during OGTT may be helpful in the identification of individuals who are at increased risk for CKD.
Epigenetic modulation of type-1 diabetes via a dual effect on pancreatic macrophages and β cells

Epigenetic modifiers are an emerging class of anti-tumor drugs, potent in multiple cancer contexts. Their effect on spontaneously developing autoimmune diseases has been little explored. We report that a short treatment with I-BET151, a small-molecule inhibitor of a family of bromodomain-containing transcriptional regulators, irreversibly suppressed development of type-1 diabetes in NOD mice. The inhibitor could prevent or clear insulitis, but had minimal influence on the transcriptomes of infiltrating and circulating T cells. Rather, it induced pancreatic macrophages to adopt an anti-inflammatory phenotype, impacting the NF-κB pathway in particular. I-BET151 also elicited regeneration of islet β-cells, inducing proliferation and expression of genes encoding transcription factors key to β-cell differentiation/function. The effect on β cells did not require T cell infiltration of the islets. Thus, treatment with I-BET151 achieves a ‘combination therapy’ currently advocated by many diabetes investigators, operating by a novel mechanism that coincidentally dampens islet inflammation and enhances β-cell regeneration. DOI: http://dx.doi. org/10.7554/eLife.04631. 001
Voyager 2 Radio Science Observations of the Uranian System: Atmosphere, Rings, and Satellites

Voyager 2 radio occultation measurements of the Uranian atmosphere were obtained between 2 and 7 degrees south latitude. Initial atmospheric temperature profiles extend from pressures of 10 to 900 millibars over a height range of about 100 kilometers. Comparison of radio and infrared results yields mole fractions near the tropopause of 0.85 and 0.15 � 0.05 for molecular hydrogen and helium, respectively, if no other components are present; for this composition the tropopause is at about 52 kelvins and 110 millibars. Distinctive features in the signal intensity measurements for pressures above 900 millibars strongly favor model atmospheres that include a cloud deck of methane ice. Modeling of the intensity measurements for the cloud region and below indicates that the cloud base is near 1,300 millibars and 81 kelvins and yields an initial methane mole fraction of about 0.02 for the deep atmosphere. Scintillations in signal intensity indicate small-scale stucture throughout the stratosphere and upper troposphere. As judged from data obtained during occultation ingress, the ionosphere consists of a multilayer structure that includes two distinct layers at 2,000 and 3,500 kilometers above the 100-millibar level and an extended topside that may reach altitudes of 10,000 kilometers or more. Occultation measurements of the nine previously known rings at wavelengths of 3.6 and 13 centimeters show characteristic values of optical depth between about 0.8 and 8; the maxim value occurs in the outer region of the ∈ ring, near its periapsis. Forward-scattered signals from this ring have properties that differ from those of any of Saturn's rings, and they are inconsistent with a discrete scattering object or local (three-dimensional) assemblies of orbiting objects. These signals suggest a new kdnd of planetary ring feature characterized by highly ordered cylindrical substructures of radial scale on the order of meters and azimuthal scale of kilometers or more. From radio data alone the mass of the Uranian system is GMsys = 5,794,547– 60 cubic kilometers per square second; from a combination of radio and optical navigation data the mass of Uranus alone is GMu = 5,793,939� 60 cubic kilometers per square second. From all available Voyager data, induding imaging radii, the mean uncompressed density of the five major satellites is 1.40� 0.07 grams per cubic centimeter; this value is consistent with a solar mix of material and apparently rules out a cometary origin of the satellites.
High precision control of robot manipulators via finite-time P-PI control

High precision position control of robot manipulators is a fundamental and important control problem. In this paper, we propose a homogeneous finite-time P-PI controller for joint angle control of robot manipulators, and then propose a finite-time P-PI controller for end-effector position control. Further, we prove that the proposed controllers guarantee finite-time stability if the desired position is a locally asymptotically stable equilibrium. Finally, we confirm the effectiveness of the proposed method by experiments.
Near-Infrared Adaptive Optics Imaging of the Embedded Cluster NGC 2024

We present the results of a high-resolution near-infrared adaptive optics survey of the young obscured star-forming region NGC 2024. Out of the total 73 stars detected in the adaptive optics survey of the cluster, we find three binaries and one triple. The resulting companion star fraction, 7% ± 3% in the separation range of 0. ″35-2. ″3 (145-950 AU), is consistent with that expected from the multiplicity of mature solar-type stars in the local neighborhood. Our survey was sensitive to faint secondaries, but no companions with ΔK′ > 1.2 mag are detected within 2'' of any star. The cluster has a K' luminosity function that peaks at ~12, and although our completeness limit was 17.7 mag at K', the faintest star we detected had a K' magnitude of 16.62.
Channel Characterization for Single- and Multiple-Antenna Wearable Systems Used for Indoor Body-to-Body Communications

In this paper, an analysis of radio channel characteristics for single- and multiple-antenna bodyworn systems for use in body-to-body communications is presented. The work was based on an extensive measurement campaign conducted at 2.45 GHz representative of an indoor sweep and search scenario for fire and rescue personnel. Using maximum-likelihood estimation in conjunction with the Akaike information criterion (AIC), five candidate probability distributions were investigated and from these the kappa- mu distribution was found to best describe small-scale fading observed in the body-to-body channels. Additional channel parameters such as autocorrelation and the cross-correlation coefficient between fading signal envelopes were also analyzed. Low cross correlation and small differences in mean signal levels between potential dual-branch diversity receivers suggested that the prospect of successfully implementing diversity in this type application is extremely good. Moreover, using selection combination, maximal ratio, and equal gain combining, up to 8.69-dB diversity gain can be made available when four spatially separated antennas are used at the receiver. Additional improvements in the combined envelopes through lower level crossing rates and fade durations at low signal levels were also observed.
Bone Formation Mediated by Synergy‐Acting Growth Factors Embedded in a Polyelectrolyte Multilayer Film

A bifunctionalized polyelectrolyte multilayer film (PEM film) that can drive embryonic stem cells to cartilage or bone differentiation is presented. A model system is constructed from a PEM film into which transforming growth factor β1 and bone morphogenetic protein has been embedded. The synergy between both factors is required for the film to be bioactive. Osteogenesis in embryonic stem cells is induced by the film (see figure).
Kinetics of the Degradation of Anthocyanins, Phenolic Acids and Flavonols During Heat Treatments of Freeze-Dried Sour Cherry Marasca Paste

Summary The effect of heating temperature (80–120 °C) and processing time (5–50 min) on the stability of anthocyanins (cyanidin-3-glucosylrutinoside, cyanidin-3-rutinoside and cyanidin-3-glucoside), quercetin-3-glucoside and phenolic acids (chlorogenic, neochlorogenic, p-coumaric and ferulic acids) in freeze-dried Marasca sour cherry pastes was studied. The degradation rates of individual anthocyanins, quercetin-3-glucoside and phenolic acids followed the first order reaction kinetics. Cyanidin-3-glucoside was found to be the most unstable among the anthocyanins, together with p-coumaric and neochlorogenic acids among other phenols. Activation energies for anthocyanin degradation ranged from 42 (cyanidin-3-glucosylrutinoside) to 55 kJ/mol (cyanidin-3-glucoside), and for other phenols from 8.12 (chlorogenic acid) to 27 kJ/mol (neochlorogenic acid). By increasing the temperature from 80 to 120 °C, the reaction rate constant of cyanidin-3-glucosylrutinoside increased from 2.2·10 –2 to 8.5·10 –2 min –1 ,o fp-coumaric acid from 1.12·10 –2 to 2.5·10 –2 min –1 and of quercetin-3-glucoside from 1.5·10 –2 to 2.6·10 –2 min –1 . The obtained results demonstrate that at 80 °C the half-life of anthocyanins ranges from 32.10 min for cyanidin-3-glucosylrutinoside to 45.69 min for cyanidin-3-rutinoside, and of other phenolic compounds from 43.39 for neochlorogenic acid to 66.99 min for chlorogenic acid. The results show that the heating temperature and duration affect the anthocyanins considerably more than the other phenols in terms of degradation.
Is there "Metabolic" DNA in the Mouse Seminal Vesicle?

This study was designed to answer the question: Is H3-thymidine uptake by nuclei of the mouse seminal vesicle evidence for DNA synthesis and mitosis, or does it signify some "metabolic" function of DNA unrelated to chromosome duplication? Mice were given an intraperitoneal injection of H3-thymidine. Six hours later Feulgen squashes of the seminal vesicle epithelium were made and covered with autoradiographic stripping film. The silver grains above labeled nuclei were counted, and the Feulgen dye contents of these same nuclei were determined photometrically after removal of the grains from the emulsion. Unlabeled nuclei were also measured. The dye contents of non-radioactive nuclei form a unimodal distribution, indicating that polyploidy is absent from this tissue. The radioactive nuclei fall into two groups. In the first, the average dye content is the same as that of the cold nuclei (2C). In the second, the values range from 2C to 4C. In the 2C to 4C group the grain count is proportional to the dye content, showing that incorporation is correlated with synthesis. The radioactive 2C nuclei arose by mitosis during the course of the experiment. This is shown by the following facts: (1) They frequently occur in pairs. (2) They average smaller than unlabeled 2C nuclei. (3) Their average grain count is approximately half that of the 4C nuclei. (4) Labeled division figures are found. (5) A mitotic rate estimated from the number of labeled 2C nuclei accords reasonably well with one based on the number of observed mitoses. Since the incorporation of thymidine accompanies DNA synthesis and precedes mitosis, there is no reason to postulate a special "metabolic" DNA in this tissue.
DEXA or BMI: Clinical Considerations for Evaluating Obesity in Collegiate Division I-A American Football Athletes

Objective:To evaluate the relationship between body mass index (BMI) and %body fat (%Fat) in collegiate football athletes (FBA) compared with age-matched/gender-matched general population volunteers (comparison group, CG) and compare body composition and overweight/obese frequencies by BMI between FBA and CG. Design:Cross-sectional. Setting:Two Division I-A (D-IA) universities in Texas. Integrative Health Technologies (San Antonio, Texas) laboratory. Participants:Football athletes (n = 156, 20.0 ± 1.3 years, 185.6 ± 6.5cm, 103.3 ± 20.4 kg). Comparison group (n = 260, 21.5 ± 2.7 years, 179.0 ± 7.6 cm, 86.3 ± 20.9 kg). Statistical Analysis:Body mass index and bone densitrometry (DEXA) body composition were assessed. Regression was used to predict %Fat from BMI in CG and FBA. To compare %Fat, fat mass (FM), fat-free mass (FFM), and weight (WT) between CG, FBA, linemen, and non-linemen, 1 × 4 analysis of variance was used. Chi-square analysis was used to compare the frequency of BMI ≥25 between groups. Results:Body mass index differently predicted %Fat for CG (r2 = 0.643, SE = 6.258) and FBA (r2 =0.769, SE = 4.416). Body mass index cutoffs for overweight/obese corresponded to the following %Fat in each group [BMI ≥25 = 19.9% (CG) and 11.1% (FBA); BMI ≥30 = 27.3% (CG) and 20.2% (FBA)]. Football athletes had significantly higher WT, BMI, FFM, and frequency of BMI ≥25 with lower %Fat and FM than CG (&agr; < 0.05). Linemen had the highest WT, BMI, FFM, %Fat, and frequency of BMI ≥25. Conclusions:The relationship between BMI and %Fat differed between CG and FBA. Using current BMI thresholds for obesity in FBA may result in misleading inferences about health risk.
HDAC2 regulates chromatin plasticity and enhances DNA vulnerability

Histone deacetylases (HDAC) may have a prominent role in the development of cancer and the response to anticancer therapy. However, the therapeutic relevance and tissue specificity of individual HDAC enzymes remain largely unknown. HDAC inhibitors may function as sensitizing agents to chemotherapies that target DNA through their effects on chromatin structure and plasticity. Here, we report a new role for HDAC2 as a regulator of chromatin compaction status and the mediator of HDAC inhibitor-induced sensitization to chemotherapy. The selective depletion of HDAC2 by small interfering RNA led to reduced expression of heterochromatin maintenance proteins and morphologic changes indicative of chromatin decondensation. Furthermore, depletion of HDAC2 but not HDAC1 or HDAC6 was sufficient to sensitize breast cancer cells to topoisomerase inhibitor-induced apoptosis. The levels of HDAC2 expression appear to correlate with the degree of HDAC inhibitor-induced histone acetylation in a surrogate tissue in patients. These data suggest that HDAC2 may be a relevant pharmacologic and biological target for combination therapy involving drugs that target DNA. [Mol Cancer Ther 2009;8(4):794–801]
Comparison of massive blood transfusion predictive models in the rural setting

Background: Hemorrhage is the leading cause of preventable death in trauma patients, of which 3% require massive transfusion (MT). MT predictive models such as the Assessment of Blood Consumption (ABC), Trauma-Associated Severe Hemorrhage (TASH), and McLaughlin scores have been developed, but only included patients requiring blood transfusion during their hospital stay, excluding a large percentage of trauma patients. Our purpose was to validate these MT predictive models in our rural Level I trauma center patient population, using all major trauma victims, regardless of blood product requirements. Methods: Review of all Level I trauma patients admitted in 2008 to 2009 was performed. ABC, TASH, and McLaughlin scores were calculated using 80% probability for the need for MT. Results: Three hundred seventy-three patients were admitted; 13% had a penetrating mechanism and 52% were scene transports. MT patients had higher Injury Severity Score (median, 43 vs. 13; p < 0.001) and lower Trauma-Injury Severity Score (0.310 vs. 0.983; p < 0.001). Mortality was higher in MT patients (18.4% vs. 5.4%; p < 0.009). Thirty-eight (10%) required MT; 34 were predicted by ABC, one by TASH, and six by McLaughlin. ABC (area under the receiver operating characteristic [AUROC] = 0.86) was predictive of MT, whereas TASH (AUROC = 0.51) and McLaughlin (AUROC = 0.56) were not. Conclusions: The ABC score correctly identified 89% of MT patients and was predictive of MT in major trauma patients at our rural Level I trauma center; the TASH and McLaughlin scores were not. The ABC score is simpler, faster, and more accurate. Based on this work, we strongly recommend adoption of the ABC score for MT prediction. Level of Evidence: III.