Miracle-dz/UniFAR-FTUs huggingface dataset:
College Student Smokers' Cognitive Appraisal of High-Risk Activities

Abstract Objective: Students who smoke are more likely to engage in risky behaviors such as binge drinking and unprotected sex (Schnieder and Morris, Environ Behav. 1999; 23:575–591). The goals of the present study were to determine whether smokers assess these behaviors as lower risk than nonsmokers, and if smoking rate influences risk perceptions. Methods: Participants were 303 college students. Cognitive Appraisal of Risky Activities (Fromme et al., Cognit Ther Res. 1997; 21:421–442) and smoking were assessed August–November, 2006. Results: Smokers reported significantly less risk, more benefit, and more involvement in risky behaviors than nonsmokers (p < .01). In hierarchical linear regression, risk perceptions moderated the association between smoking and (a) expected benefit from risky sexual behaviors (β = −1.121, p < .05); and (b) expected involvement with illicit drugs (β = −.313, p < .01). Conclusions: College smokers’ assessment of high-risk behaviors influenced their intended involvement. Risk perception change may therefore alter their involvement in high-risk behaviors.
Nonlinear Adjustment in Real Exchange Rates and Long Run Purchasing Power Parity--Further Evidence

The paper investigates, using a threshold autoregression model, the nature of nonlinear adjustments in real exchange rates (RERs) arising from the presence of transaction costs and uncertainty, and their implications for the testing of unit roots. Using monthly data for the U.S. vis-a-vis 19 trading partners we find that most RERs are better characterized by a mean reverting nonlinear stochastic process, with large changes converging faster than small changes, implying that there is convergence towards PPP equilibrium at least in the long-run, albeit in a non-linear manner. It is found that, across countries and commodity groups, there is an association between geographical and trade related proximity and the estimated speeds of adjustment. In addition, policy agreements that mitigate exchange rate uncertainty such as the Louvre Accord could have contributed to greater international commodity arbitrage.
Reliability Improvement By Adopting Ti‐barrier Metal For Porous Low‐k ILD Structure

Titanium (Ti) has been proposed as an excellent barrier metal (BM) material for ULSI's Cu metallization from the stand point of two characteristics. One is the oxidation property, especially for the porous low‐k ILD materials for 45 nm node device; the other is the interface behavior of Ti with Cu. Both stress induced voiding (SIV) suppression and one order longer electromigration (EM) lifetime were obtained by the adoption of Ti‐BM instead of the conventional Tantalum (Ta)‐BM. SIV failure is accelerated in porous low‐k ILD by the following steps; 1) BM oxidation by the absorbed moisture in porous low‐k ILD, 2) Adhesion degradation caused by the BM oxidation results in micro delamination of Cu film (void nucleation), 3) Void growth induced by the stress gradient in the Cu interconnect. It has been considered that the small volume change of Ti oxidation and the existence of metallic Ti‐O solid‐solution phase would be the reason for control of moisture penetration from the low‐k ILD materials. In addition, .
Mixed-integer quadrangulation

We present a novel method for quadrangulating a given triangle mesh. After constructing an as smooth as possible symmetric cross field satisfying a sparse set of directional constraints (to capture the geometric structure of the surface), the mesh is cut open in order to enable a low distortion unfolding. Then a seamless globally smooth parametrization is computed whose iso-parameter lines follow the cross field directions. In contrast to previous methods, sparsely distributed directional constraints are sufficient to automatically determine the appropriate number, type and position of singularities in the quadrangulation. Both steps of the algorithm (cross field and parametrization) can be formulated as a mixed-integer problem which we solve very efficiently by an adaptive greedy solver. We show several complex examples where high quality quad meshes are generated in a fully automatic manner.
Barrier invariants: a shared state abstraction for the analysis of data-dependent GPU kernels

Data-dependent GPU kernels, whose data or control flow are dependent on the input of the program, are difficult to verify because they require reasoning about shared state manipulated by many parallel threads. Existing verification techniques for GPU kernels achieve soundness and scalability by using a two-thread reduction and making the contents of the shared state nondeterministic each time threads synchronise at a barrier, to account for all possible thread interactions. This coarse abstraction prohibits verification of data-dependent kernels. We present barrier invariants, a novel abstraction technique which allows key properties about the shared state of a kernel to be preserved across barriers during formal reasoning. We have integrated barrier invariants with the GPUVerify tool, and present a detailed case study showing how they can be used to verify three prefix sum algorithms, allowing efficient modular verification of a stream compaction kernel, a key building block for GPU programming. This analysis goes significantly beyond what is possible using existing verification techniques for GPU kernels.
Pol II–Expressed shRNA Knocks Down Sod2 Gene Expression and Causes Phenotypes of the Gene Knockout in Mice

RNA interference (RNAi) has been used increasingly for reverse genetics in invertebrates and mammalian cells, and has the potential to become an alternative to gene knockout technology in mammals. Thus far, only RNA polymerase III (Pol III)–expressed short hairpin RNA (shRNA) has been used to make shRNA-expressing transgenic mice. However, widespread knockdown and induction of phenotypes of gene knockout in postnatal mice have not been demonstrated. Previous studies have shown that Pol II synthesizes micro RNAs (miRNAs)—the endogenous shRNAs that carry out gene silencing function. To achieve efficient gene knockdown in mammals and to generate phenotypes of gene knockout, we designed a construct in which a Pol II (ubiquitin C) promoter drove the expression of an shRNA with a structure that mimics human miRNA miR-30a. Two transgenic lines showed widespread and sustained shRNA expression, and efficient knockdown of the target gene Sod2. These mice were viable but with phenotypes of SOD2 deficiency. Bigenic heterozygous mice generated by crossing these two lines showed nearly undetectable target gene expression and phenotypes consistent with the target gene knockout, including slow growth, fatty liver, dilated cardiomyopathy, and premature death. This approach opens the door of RNAi to a wide array of well-established Pol II transgenic strategies and offers a technically simpler, cheaper, and quicker alternative to gene knockout by homologous recombination for reverse genetics in mice and other mammalian species.
Synergy of the antibiotic colistin with echinocandin antifungals in Candida species.

OBJECTIVES Candida albicans is the most prevalent fungal pathogen of humans, causing a wide range of infections from harmless superficial to severe systemic infections. Improvement of the antifungal arsenal is needed since existing antifungals can be associated with limited efficacy, toxicity and antifungal resistance. Here we aimed to identify compounds that act synergistically with echinocandin antifungals and that could contribute to a faster reduction of the fungal burden. METHODS A total of 38 758 compounds were tested for their ability to act synergistically with aminocandin, a β-1,3-glucan synthase inhibitor of the echinocandin family of antifungals. The synergy between echinocandins and an identified hit was studied with chemogenomic screens and testing of individual Saccharomyces cerevisiae and C. albicans mutant strains. RESULTS We found that colistin, an antibiotic that targets membranes in Gram-negative bacteria, is synergistic with drugs of the echinocandin family against all Candida species tested. The combination of colistin and aminocandin led to faster and increased permeabilization of C. albicans cells than either colistin or aminocandin alone. Echinocandin susceptibility was a prerequisite to be able to observe the synergy. A large-scale screen for genes involved in natural resistance of yeast cells to low doses of the drugs, alone or in combination, identified efficient sphingolipid and chitin biosynthesis as necessary to protect S. cerevisiae and C. albicans cells against the antifungal combination. CONCLUSIONS These results suggest that echinocandin-mediated weakening of the cell wall facilitates colistin targeting of fungal membranes, which in turn reinforces the antifungal activity of echinocandins.
Hypervelocity Stars: From the Galactic Center to the Halo

Hypervelocity stars (HVSs) traverse the Galaxy from the central black hole to the outer halo. We show that the Galactic potential within 200 pc acts as a high-pass filter preventing low-velocity HVSs from reaching the halo. To trace the orbits of HVSs throughout the Galaxy, we construct two forms of the potential which reasonably represent the observations in the range 5-105 pc: a simple spherically symmetric model and a bulge-disk-halo model. We use the Hills mechanism (disruption of binaries by the tidal field of the central black hole) to inject HVSs into the Galaxy and to compute the observable spatial and velocity distributions of HVSs with masses in the range 0.6-4 M☉. These distributions reflect the mass function in the Galactic center, properties of binaries in the Galactic center, and aspects of stellar evolution and the injection mechanism. For 0.6-4 M☉ main-sequence stars, the fraction of unbound HVSs and the asymmetry of the velocity distribution for their bound counterparts increase with stellar mass. The density profiles for unbound HVSs decline with distance from the Galactic center approximately as r−2 (but are steeper for the most massive stars, which evolve off the main sequence during their travel time from the Galactic center); the density profiles for the bound ejecta decline with distance approximately as r−3. In a survey with a limiting magnitude of V≲ 23, the detectability of HVSs (unbound or bound) increases with stellar mass.
Effect of main compositions of anti-washout admixture on paste

Abstract Anti-washout admixture compositions include slurry stabiliser, adjuvant, setting retarder, superplasticiser, strength enhancer and so on. Among the composites, slurry stabiliser and adjuvant are the main compositions for washout resistance. In this study, anti-dispersion of slurry stabiliser and adjuvant was tested by pH value, turbidity and suspension particle content of surrounding water, at last, analysed appropriate dosage based on test results.
[Importance of quality of life assessment in patients with endometriosis].

PURPOSE The present study examined the relationship between some clinical variables and quality of life in a group of patients with endometriosis. METHODS A total of 130 women seen at a multidisciplinary center specializing in gynecology endometriosis in 2008 participated in the study. This was a cross-sectional study conducted with a convenience sample. The diagnosis of endometriosis was performed by biopsy according to the criteria of the American Society for Reproductive Medicine. The clinical and demographic data were collected from the patients' records. Pain intensity was assessed by a visual numerical scale (0-10), and data on the quality of life were collected using the SF-36. Data analysis consisted of descriptive and inferential statistical tests, Spearman correlation coefficient and Kruskal-Wallis test to compare scores between groups. Nonparametric tests were used for analysis because data were not normally distributed. RESULTS The patients were 21 to 54 years of age or 34, standard diversion (SD)=6.56], 87% had a university degree, and 75% were married. Seventeen percent reported cases of endometriosis in the family. The average time of onset of symptoms was 4.5 years (SD=6.6), 63% of patients were in stage 3 or 4 of endometriosis 36% of patients had severe or disabling dysmenorrhea and the average intensity of pain according to a visual numerical scale was of 5.6 (SD=3.5). Results suggest that the staging of the disease did not determine the intensity of pain. The time of onset of symptoms also showed no relationship to pain intensity and SF-36 scores. On the other hand, the intensity of pain was associated with lower scores on some scales of the SF-36. CONCLUSION Patients with endometriosis had lower scores of quality of life than the general population and lower than those of some other diseases.
Circadian Variation in Ischemic Threshold: A Mechanism Underlying the Circadian Variation in Ischemic Events

BackgroundThere is a circadian pattern in the occurrence of cardiac events in patients with coronary artery disease. Whether changes in coronary vascular tone contribute to these phenomena is unknown. We measured the ischemic threshold, defined as either the heart rate or rate-pressure product at 1-mm ST segment depression during treadmill exercise and used it as an index of the lowest coronary vascular resistance; the premise was that when ischemic threshold became lower, coronary vascular resistance was higher, and vice versa. Methods and ResultsFifteen patients (group A) with stable coronary artery disease underwent four identical treadmill exercise tests in 24 hours, and ischemic threshold was measured as the heart rate at the onset of 1-mm ST depression. Before each treadmill test, postischemic forearm vascular resistance was measured after 5 minutes of forearm occlusion, using strain-gauge plethysmography. Sixteen additional patients (group B) underwent two treadmill tests at 8 AM and 1 PM, and ischemic threshold was measured as the heart rate-blood pressure product at 1-mm ST depression. A circadian variation was noted: In group A, the heart rate-derived ischemic threshold was lower at 8 AM and 9 PM compared with noon and 5 PM (p<0.03). Also, in group B, the rate-pressure product-derived ischemic threshold was 8±2% lower at 8 AM compared with 1 PM (p = 0.008). A circadian variation parallel to the observed variation in ischemic threshold was also noted in the postischemic forearm blood flow, which was lower in the morning and at night (p<0.004). There was a strong correlation between postischemic forearm blood flow and ischemic threshold (p<0.0001), such that ischemic threshold was lower at the time of day when postischemic forearm blood flow was lower, and vice versa. ConclusionsA lower ischemic threshold in the morning suggests that the ischemia-induced coronary vascular resistance is increased at this time, a finding supported by a similar variation in postischemic forearm vascular resistance. Parallel changes in forearm and coronary resistance suggest that generalized (neural or humoral factors) rather than local factors are responsible for the observed circadian changes. Increased coronary tone in the mornings may not only contribute to the higher incidence of transient ischemia but may help trigger acute cardiac events at this time.
Tectonics Seismic anisotropy andmantle dynamics beneath the Malawi Rift Zone , East Africa

SKS, SKKS, and PKS splitting parameters measured at 34 seismic stations that we deployed in the vicinity of the Cenozoic Malawi Rift Zone (MRZ) of the East African Rift System demonstrate systematic spatial variations with an average splitting time of 1.0 ± 0.3 s. The overall NE-SW fast orientations are consistent with absolute plate motion (APM) models of the African Plate constructed under the assumption of no-net rotation of the global lithosphere and are inconsistent with predicted APM directions from models employing a fixed hot spot reference frame. They also depart considerably from the trend of most of the major tectonic features. These observations, together with the results of anisotropy depth estimation using the spatial coherency of the splitting parameters, suggest a mostly asthenospheric origin of the observed azimuthal anisotropy. The single-layered anisotropy observed at 30 and two-layered anisotropy observed at 4 of the 34 stations can be explained by APM-related simple shear within the rheologically transitional layer between the lithosphere and asthenosphere, as well as by the horizontal deflection of asthenospheric flow along the southern and western edges of a continental block with relatively thick lithosphere revealed by previous seismic tomography and receiver function investigations. This first regional-scale shear wave splitting investigation of the MRZ suggests the absence of rifting-related active mantle upwelling or small-scale mantle convection and supports a passive-rifting process for the MRZ.
Elevated Levels of Peripheral Kynurenine Decrease Bone Strength in Rats with Chronic Kidney Disease

The diagnosis and treatment of bone disorders in patients with chronic kidney disease (CKD) represent a clinical challenge. CKD leads to mineral and bone complications starting early in the course of renal failure. Recently, we have observed the positive relationship between intensified central kynurenine turnover and bone strength in rats with subtotal 5/6 nephrectomy (5/6 Nx)-induced CKD. The aim of the present study was to determine the association between peripheral kynurenine pathway metabolites and bone strength in rats with 5/6 Nx-induced CKD. The animals were sacrificed 1 and 3 months after 5/6 Nx or sham operation. Nephrectomized rats presented higher concentrations of serum creatinine, urea nitrogen, and parathyroid hormone both 1 and 3 months after nephrectomy. These animals revealed higher concentrations of kynurenine and 3-hydroxykynurenine in the serum and higher gene expression of aryl hydrocarbon receptor (AhR) as a physiological receptor for kynurenine and AhR-dependent cytochrome in the bone tissue. Furthermore, nephrectomy significantly increased the number of osteoclasts in the bone without affecting their resorptive activity measured in serum. These changes were particularly evident in rats 1 month after 5/6 Nx. The main bone biomechanical parameters of the tibia were unchanged between nephrectomized and sham-operated rats but were significantly increased in older compared to younger animals. A similar trend was observed for geometrical parameters measured with calipers, bone mineral density based on Archimedes' method and image of bone microarchitecture obtained from micro-computed tomography analyses of tibial cortical bone. In nephrectomized animals, peripheral kynurenine levels correlated negatively with the main parameters of bone biomechanics, bone geometry, and bone mineral density values. In conclusion, our data suggest that CKD-induced elevated levels of peripheral kynurenine cause pathological changes in bone structure via AhR pathway. This finding opens new opportunities for the treatment/prevention of osteoporosis in CKD.
Circadian Changes in the Sputum of Asthmatic Subjects and Healthy Controls

BackgroundAsthma is exhibiting classical circadian fluctuations of clinical symptoms and airflow measurements, presumably influenced by the underlying airway inflammation and the endogenous cortisol secretion. The aim of our study was to examine the cellular and eosinophilic cationic protein (ECP) contents of sputum, collected and frozen at 2 opposite time points of the day-and-night cycle, and to correlate them to blood cortisol levels.MethodsThirteen subjects with uncontrolled asthma (8 men, aged 25-54 years) and 10 healthy subjects (6 men, aged 25-50 years) volunteered for the study. They were induced with hypertonic saline to produce sputum between 8:00 AM and 9:00 AM and between 8:00 PM and 9:00 PM, when blood was also withdrawn to measure cortisol levels.ResultsAsthmatic subjects did not display significant morning/evening differences in their sputum total cell counts ([TCCs] median, 2.06 × 103 cells/mL; range 0.50-5.66 cells/mL vs median, 1.29 cells/mL; range, 0.24-9.26 cells/mL, P > 0.1), whereas controls had a well-defined morning peak (median, 0.75 cells/mL; range, 0.31-2.25 cells/mL vs median, 0.33 cells/mL; range, 0.1-0.97 cells/mL, P > 0.001). Asthmatic subjects had significantly higher sputum TCC than controls in the evening (P < 0.001), but their morning TCC did not significantly exceed those of the healthy subjects. Asthmatic subjects had significantly more sputum eosinophils and higher ECP levels than controls but failed to demonstrate significant morning/evening differences in contrast to the controls who had higher morning eosinophils and ECP. Macrophages were relatively increased in the evening samples of both asthmatic subjects and controls. No significant correlations between the circadian cortisol shift and any of the sputum indices were found.ConclusionsSputum undergoes circadian changes, which are different in health and in asthma and do not correlate with endogenous cortisol levels.
Analysis of human-operated motions and trajectory replanning for kinematically redundant manipulators

We consider trajectory planning for kinematically redundant manipulators used on forestry machines. The analysis of recorded data from human operation reveals that the driver does not use the full potential of the machine due to the complexity of the manipulation task. We suggest an optimization procedure that takes advantage of the kinematic redundancy so that time-efficient joint and velocity profiles along the path can be obtained. Differential constraints imposed by the manipulator dynamics are accounted for by employing a phase-plane technique for admissible path timings. Velocity constraints of the individual joints are particularly restrictive in hydraulic manipulators. Our study aims for semi-autonomous schemes that can provide assistance to the operator for executing global motions.
A Representation Learning Framework for Multi-Source Transfer Parsing

Cross-lingual model transfer has been a promising approach for inducing dependency parsers for low-resource languages where annotated treebanks are not available. The major obstacles for the model transfer approach are two-fold: 1. Lexical features are not directly transferable across languages; 2. Target language-specific syntactic structures are difficult to be recovered. To address these two challenges, we present a novel representation learning framework for multi-source transfer parsing. Our framework allows multi-source transfer parsing using full lexical features straightforwardly. By evaluating on the Google universal dependency treebanks (v2.0), our best models yield an absolute improvement of 6.53% in averaged labeled attachment score, as compared with delexicalized multi-source transfer models. We also significantly outperform the state-of-the-art transfer system proposed most recently.