Miracle-dz/UniFAR-FTUs huggingface dataset:
A technique for the identification and analysis of icebergs in synthetic aperture radar images of Antarctica

This paper describes an image analysis technique developed to identify icebergs depicted in synthetic aperture radar images of Antarctica and to determine the outlines of these icebergs. The technique uses a pixel bonding process to delineate the edges of the icebergs. It then separates them from the background water and sea ice by an edge-guided image segmentation process. Characteristics such as centroid position and iceberg area are calculated for each iceberg segment and placed in a file for input to appropriate statistical data analysis software. The technique has been tested on three ERS-1 SAR sub-images in which it succeeded in identifying virtually all segments containing icebergs of size 6 pixels or larger. The images were first passed through an averaging filter to reduce speckle. This process produced a pixel size of 100 m x 100 m. As implemented, the technique over-estimates iceberg areas by about 20% on average and the detection rate falls off rapidly for icebergs less than six pixels in size. Performance in these areas is expected to improve when additional stages, based on a more detailed analysis of pixel intensity, are implemented.
Corporate reputation and sustained superior financial performance

Good corporate reputations are critical because of their potential for value creation, but also because their intangible character makes replication by competing firms considerably more difficult. Existing empirical research confirms that there is a positive relationship between reputation and financial performance. This paper complements these findings by showing that firms with relatively good reputations are better able to sustain superior profit outcomes over time. In particular, we undertake an analysis of the relationship between corporate reputation and the dynamics of financial performance using two complementary dynamic models. We also decompose overall reputation into a component that is predicted by previous financial performance, and that which is ‘left over’, and find that each (orthogonal) element supports the persistence of above-average profits over time. Copyright © 2002 John Wiley & Sons, Ltd.
Identifying patients with ischaemic heart disease in general practice: cross sectional study of paper and computerised medical records

Abstract Objectives: To identify patients with ischaemic heart disease by using a practice computer and to estimate the work required to do so. Design: Cross sectional study. Data from the notes and from the computer records of 1680 patients were used to build a database. This was used to compare different methods of identifying patients with ischaemic heart disease. Setting: 11 general practices in the Battersea primary care group in south London. Subjects: 1 in 40 random sample of patients aged 45 or older. Main outcome measures: Numbers of patients identified with ischaemic heart disease. Results: The combination of the Read code for ischaemic heart disease (G3) and a prescription for a nitrate had a 73% sensitivity and a yield (100/positive predictive value) of one case of ischaemic heart disease for every 1.2 sets of notes reviewed. By searching the records of patients also receiving aspirin, atenolol, digoxin, or a statin, the sensitivity was increased to 96% but the yield fell to one in three. Conclusion: Although commonly used to identify cases, a computer search for G3 code or nitrate missed almost 30% of patients with ischaemic heart disease. A substantially higher percentage of patients can be identified by adding other drugs to the search strategy.
Data exploration, quality control and testing in single-cell qPCR-based gene expression experiments

Motivation: Cell populations are never truly homogeneous; individual cells exist in biochemical states that define functional differences between them. New technology based on microfluidic arrays combined with multiplexed quantitative polymerase chain reactions now enables high-throughput single-cell gene expression measurement, allowing assessment of cellular heterogeneity. However, few analytic tools have been developed specifically for the statistical and analytical challenges of single-cell quantitative polymerase chain reactions data. Results: We present a statistical framework for the exploration, quality control and analysis of single-cell gene expression data from microfluidic arrays. We assess accuracy and within-sample heterogeneity of single-cell expression and develop quality control criteria to filter unreliable cell measurements. We propose a statistical model accounting for the fact that genes at the single-cell level can be on (and a continuous expression measure is recorded) or dichotomously off (and the recorded expression is zero). Based on this model, we derive a combined likelihood ratio test for differential expression that incorporates both the discrete and continuous components. Using an experiment that examines treatment-specific changes in expression, we show that this combined test is more powerful than either the continuous or dichotomous component in isolation, or a t-test on the zero-inflated data. Although developed for measurements from a specific platform (Fluidigm), these tools are generalizable to other multi-parametric measures over large numbers of events. Availability: All results presented here were obtained using the SingleCellAssay R package available on GitHub (http://github.com/RGLab/SingleCellAssay). Contact: rgottard@fhcrc.org Supplementary information: Supplementary data are available at Bioinformatics online.
Frequency and Intensive Care Related Risk Factors of Pneumothorax in Ventilated Neonates

Objectives. Relationships of mechanical ventilation to pneumothorax in neonates and care procedures in particular are rarely studied. We aimed to evaluate the relationship of selected ventilator variables and risk events to pneumothorax. Methods. Pneumothorax was defined as accumulation of air in pleural cavity as confirmed by chest radiograph. Relationship of ventilator mode, selected settings, and risk procedures prior to detection of pneumothorax was studied using matched controls. Results. Of 540 neonates receiving mechanical ventilation, 10 (1.85%) were found to have pneumothorax. Respiratory distress syndrome, meconium aspiration syndrome, and pneumonia were the underlying lung pathology. Pneumothorax mostly (80%) occurred within 48 hours of life. Among ventilated neonates, significantly higher percentage with pneumothorax received mandatory ventilation than controls (70% versus 20%; P < 0.01). Peak inspiratory pressure >20 cm H2O and overventilation were not significantly associated with pneumothorax. More cases than controls underwent care procedures in the preceding 3 hours of pneumothorax event. Mean airway pressure change (P = 0.052) and endotracheal suctioning (P = 0.05) were not significantly associated with pneumothorax. Reintubation (P = 0.003), and bagging (P = 0.015) were significantly associated with pneumothorax. Conclusion. Pneumothorax among ventilated neonates occurred at low frequency. Mandatory ventilation and selected care procedures in the preceding 3 hours had significant association.
Cyclin D1 silencing suppresses tumorigenicity, impairs DNA double strand break repair and thus radiosensitizes androgen-independent prostate cancer cells to DNA damage

Patients with hormone-resistant prostate cancer (PCa) have higher biochemical failure rates following radiation therapy (RT). Cyclin D1 deregulated expression in PCa is associated with a more aggressive disease: however its role in radioresistance has not been determined. Cyclin D1 levels in the androgen-independent PC3 and 22Rv1 PCa cells were stably inhibited by infecting with cyclin D1-shRNA. Tumorigenicity and radiosensitivity were investigated using in vitro and in vivo experimental assays. Cyclin D1 silencing interfered with PCa oncogenic phenotype by inducing growth arrest in the G1 phase of cell cycle and reducing soft agar colony formation, migration, invasion in vitro and tumor formation and neo-angiogenesis in vivo. Depletion of cyclin D1 significantly radiosensitizes PCa cells by increasing the RT-induced DNA damages by affecting the NHEJ and HR pathways responsible of the DNA double-strand break repair. Following treatment of cells with RT the abundance of a biomarker of DNA damage, γ-H2AX, was dramatically increased in sh-cyclin D1 treated cells compared to shRNA control. Concordant with these observations DNA-PKcs-activation and RAD51-accumulation, part of the DNA double-strand break repair machinery, were reduced in shRNA-cyclin D1 treated cells compared to shRNA control. We further demonstrate the physical interaction between CCND1 with activated-ATM, -DNA-PKcs and RAD51 is enhanced by RT. Finally, siRNA-mediated silencing experiments indicated DNA-PKcs and RAD51 are downstream targets of CCND1-mediated PCa cells radioresistance. In summary, these observations suggest that CCND1 is a key mediator of PCa radioresistance and could represent a potential target for radioresistant hormone-resistant PCa.
A Bistable Switch and Anatomical Site Control Vibrio cholerae Virulence Gene Expression in the Intestine

A fundamental, but unanswered question in host-pathogen interactions is the timing, localization and population distribution of virulence gene expression during infection. Here, microarray and in situ single cell expression methods were used to study Vibrio cholerae growth and virulence gene expression during infection of the rabbit ligated ileal loop model of cholera. Genes encoding the toxin-coregulated pilus (TCP) and cholera toxin (CT) were powerfully expressed early in the infectious process in bacteria adjacent to epithelial surfaces. Increased growth was found to co-localize with virulence gene expression. Significant heterogeneity in the expression of tcpA, the repeating subunit of TCP, was observed late in the infectious process. The expression of tcpA, studied in single cells in a homogeneous medium, demonstrated unimodal induction of tcpA after addition of bicarbonate, a chemical inducer of virulence gene expression. Striking bifurcation of the population occurred during entry into stationary phase: one subpopulation continued to express tcpA, whereas the expression declined in the other subpopulation. ctxA, encoding the A subunit of CT, and toxT, encoding the proximal master regulator of virulence gene expression also exhibited the bifurcation phenotype. The bifurcation phenotype was found to be reversible, epigenetic and to persist after removal of bicarbonate, features consistent with bistable switches. The bistable switch requires the positive-feedback circuit controlling ToxT expression and formation of the CRP-cAMP complex during entry into stationary phase. Key features of this bistable switch also were demonstrated in vivo, where striking heterogeneity in tcpA expression was observed in luminal fluid in later stages of the infection. When this fluid was diluted into artificial seawater, bacterial aggregates continued to express tcpA for prolonged periods of time. The bistable control of virulence gene expression points to a mechanism that could generate a subpopulation of V. cholerae that continues to produce TCP and CT in the rice water stools of cholera patients.
Advanced industrial countries

This study addresses Europeanisation and ecological modernisation, using the case study of Finnish agriculture. It analyses the assumption that there has been a general transition towards the policies of ecological modernisation by examining changes in institutional arrangements, discourses and policy practices in the last three decades. The findings on Finnish agri‐environmental policy are somewhat contradictory. On one hand, especially in the policy discourses, there are signs of transition consistent with the ecological modernisation theory. On the other, from the institutional and practice‐oriented perspective, the evidence suggests only some minor changes, even stability in agri‐environmental regulation. We find that the Finnish response to EU regulation has been problematic from the viewpoint of agri‐environmental policy: the transition period of Finnish agriculture due to the entrance into the European market has retarded, at least temporarily, the policy process of ecological modernisation which began to emerge in the late 1980s.
Efficient DOA tracking for TDMA-based SDMA mobile communications

In this paper, we discuss subspace tracking algorithms for DOA estimation that take a burst-wise data flow-as it naturally occurs in systems using a TDMA component-into account. This leads to a matrix model rather than to the well known snapshot vector model for the sensor array outputs. Unfortunately, many existing algorithms take advantage of the vector model and do either not support the matrix model or are not efficient with it. Therefore, we derive three efficient algorithms based on the matrix model which are extensions of the known ISU and PAST methods. Furthermore, we show how changes in the number of present signals can be detected and how to incorporate this step. Simulation results are presented.
Does the fracture fragment at the anterior column in thoracolumbar burst fractures get enough attention?

Abstract Prospective cohort study. To evaluate whether failure of the fracture fragment at the anterior column reduction in thoracolumbar fracture has an influence on the final radiologic and clinical outcomes. Cervical teardrop fracture has caused wide concern in spinal surgery field. Although similar fracture fragment at the anterior column was also observed in thoracolumbar burst fractures, the conception of teardrop fracture in thoracolumbar fractures was rarely mentioned in the literature, let alone a study. Fifty patients who suffered from thoracolumbar burst fractures with a fracture fragment at the anterior column were prospectively analyzed. Twenty-seven patients in whom the fragments were reduced by posterior surgery, verified by postoperative X-ray or CT, were included in the reduced group, and 23 patients were included in the nonreduced group. Radiologic and clinical outcomes of both groups were compared after over 2 years follow-up. There was no significant difference regarding to Cobb angle, Oswestry Disability Index (ODI) score, and disc grade between the 2 groups preoperatively. At final follow-up, the mean angle of kyphosis was 13.91° ± 3.47° in the nonreduced group and 8.42° ± 2.07° in the reduced groups (P < 0.01). All fractures consolidated in the reduced group, but the nonreduced group revealed 3 cases with nonunion. Besides, the average Pfirrmann grade of degenerative disc adjacent to the fractured vertebral was 2.87 ± 1.18 in the nonreduced group, higher than 1.81 ± 0.62 in the reduced group (P < 0.01). The ODI score in the nonreduced group was 0.54 ± 0.13 and 0.36 ± 0.12 in the reduced group (P < 0.01). In the present study, failure reduction of the fracture fragment at the anterior column could result in poor radiologic and clinical outcomes of the thoracolumbar burst fractures treated with posterior surgery. Therefore, we recommend the surgeon should pay more attention to reducing the fracture fragment at the anterior column.
Impacts of Nickel Nanoparticles on Mineral Carbonation

This work presents experimental results regarding the use of pure nickel nanoparticles (NiNP) as a mineral carbonation additive. The aim was to confirm if the catalytic effect of NiNP, which has been reported to increase the dissolution of CO2 and the dissociation of carbonic acid in water, is capable of accelerating mineral carbonation processes. The impacts of NiNP on the CO2 mineralization by four alkaline materials (pure CaO and MgO, and AOD and CC steelmaking slags), on the product mineralogy, on the particle size distribution, and on the morphology of resulting materials were investigated. NiNP-containing solution was found to reach more acidic pH values upon CO2 bubbling, confirming a higher quantity of bicarbonate ions. This effect resulted in acceleration of mineral carbonation in the first fifteen minutes of reaction time when NiNP was present. After this initial stage, however, no benefit of NiNP addition was seen, resulting in very similar carbonation extents after one hour of reaction time. It was also found that increasing solids content decreased the benefit of NiNP, even in the early stages. These results suggest that NiNP has little contribution to mineral carbonation processes when the dissolution of alkaline earth metals is rate limiting.
A Pursuit of Temporal Accuracy in General Activity Detection

Detecting activities in untrimmed videos is an important but challenging task. The performance of existing methods remains unsatisfactory, e.g., they often meet difficulties in locating the beginning and end of a long complex action. In this paper, we propose a generic framework that can accurately detect a wide variety of activities from untrimmed videos. Our first contribution is a novel proposal scheme that can efficiently generate candidates with accurate temporal boundaries. The other contribution is a cascaded classification pipeline that explicitly distinguishes between relevance and completeness of a candidate instance. On two challenging temporal activity detection datasets, THUMOS14 and ActivityNet, the proposed framework significantly outperforms the existing state-of-the-art methods, demonstrating superior accuracy and strong adaptivity in handling activities with various temporal structures.
Effect of listening to Nellie the Elephant during CPR training on performance of chest compressions by lay people: randomised crossover trial

Objectives To determine whether listening to music during cardiopulmonary resuscitation (CPR) training increases the proportion of lay people delivering chest compressions of 100 per minute. Design Prospective randomised crossover trial. Setting Large UK university. Participants 130 volunteers (81 men) recruited on an opportunistic basis. Exclusion criteria included age under 18, trained health professionals, and cardiopulmonary resuscitation (CPR) training within the past three months. Interventions Volunteers performed three sequences of one minute of continuous chest compressions on a skill meter resuscitation manikin accompanied by no music, repeated choruses of Nellie the Elephant (Nellie), and That’s the Way (I like it) (TTW) according to a pre-randomised order. Main outcome measures Rate of chest compressions delivered (primary outcome), depth of compressions, proportion of incorrect compressions, and type of error. Results Median (interquartile range) compression rates were 110 (93-119) with no music, 105 (98-107) with Nellie, and 109 (103-110) with TTW. There were significant differences within groups between Nellie v no music and Nellie v TTW (P<0.001) but not no music v TTW (P=0.055). A compression rate of between 95 and 105 was achieved with no music, Nellie, and TTW for 15/130 (12%), 42/130 (32%), and 12/130 (9%) attempts, respectively. Differences in proportions were significant for Nellie v no music and Nellie v TTW (P<0.001) but not for no music v TTW (P=0.55). Relative risk for a compression rate between 95 and 105 was 2.8 (95% confidence interval 1.66 to 4.80) for Nellie v no music, 0.8 (0.40 to 1.62) for TTW v no music, and 3.5 (1.97 to 6.33) for Nellie v TTW. The number needed to treat for listening to Nellie v no music was 5 (4 to 10)—that is, the number of cardiac arrests required during which lay responders listen to Nellie to facilitate one patient receiving compressions at the correct rate (v no music) would be between four and 10. A greater proportion of compressions were too shallow when participants listened to Nellie v no music (56% v 47%, P=0.022). Conclusions Listening to Nellie the Elephant significantly increased the proportion of lay people delivering compression rates at close to 100 per minute. Unfortunately it also increased the proportion of compressions delivered at an inadequate depth. As current resuscitation guidelines give equal emphasis to correct rate and depth, listening to Nellie the Elephant as a learning aid during CPR training should be discontinued. Further research is required to identify music that, when played during CPR training, increases the proportion of lay responders providing chest compressions at both the correct rate and depth.
Democracies at War

Why do democracies win wars? This is a critical question in the study of international relations, as a traditional view--expressed most famously by Alexis de Tocqueville--has been that democracies are inferior in crafting foreign policy and fighting wars. In Democracies at War, the first major study of its kind, Dan Reiter and Allan Stam come to a very different conclusion. Democracies tend to win the wars they fight--specifically, about eighty percent of the time. Complementing their wide-ranging case-study analysis, the authors apply innovative statistical tests and new hypotheses. In unusually clear prose, they pinpoint two reasons for democracies' success at war. First, as elected leaders understand that losing a war can spell domestic political backlash, democracies start only those wars they are likely to win. Secondly, the emphasis on individuality within democratic societies means that their soldiers fight with greater initiative and superior leadership. Surprisingly, Reiter and Stam find that it is neither economic muscle nor bandwagoning between democratic powers that enables democracies to win wars. They also show that, given societal consent, democracies are willing to initiate wars of empire or genocide. On the whole, they find, democracies' dependence on public consent makes for more, rather than less, effective foreign policy. Taking a fresh approach to a question that has long merited such a study, this book yields crucial insights on security policy, the causes of war, and the interplay between domestic politics and international relations.
Party Platforms, Mandates, and Government Spending

In their 1990 Review article, Ian Budge and Richard Hofferbert analyzed the relationship between party platform emphases, control of the White House, and national government spending priorities, reporting strong evidence of a “party mandate” connection between them. Gary King and Michael Laver successfully replicate the original analysis, critique the interpretation of the causal effects, and present a reanalysis showing that platforms have small or nonexistent effects on spending. In response, Budge, Hofferbert, and Michael McDonald agree that their language was somewhat inconsistent on both interactions and causality but defend their conceptualization of “mandates” as involving only an association, not necessarily a causal connection, between party commitments and government policy. Hence, while the causes of government policy are of interest, noncausal associations are sufficient as evidence of party mandates in American politics.