Miracle-dz/UniFAR-FTUs huggingface dataset:
Pilot testing of a parent-directed intervention (Project ASPIRE) for underserved children who are deaf or hard of hearing

This pilot study explored the potential for Project ASPIRE to effect behavior change in a sample of 11 parents of children with hearing loss who were from typically underserved populations, such as families from backgrounds of low socioeconomic status or families who speak English as a second language. The study consisted of one education session, five 16-hour home audio environment recordings, and four linguistic feedback reviews. The educational session focused on child language development and early language environment enrichment strategies. Parents received ‘quantitative linguistic feedback’ on the home audio recordings to further support behavior change through increased awareness of linguistic behaviors. The audio recordings were completed with the Language ENvironment Analysis system. This system measured parental linguistic behavior (adult word count or AWC), child linguistic behavior (child vocalization count or CVC), and child–parent interactive linguistic behavior (conversational turn count or CTC). Post-intervention both CTC and CVC had increased significantly compared to pre-intervention recording counts (p < 0.01; p < 0.05). Increase in AWC trended towards significance between pre- and post-intervention recordings (p < 0.1). These preliminary findings support ‘quantitative linguistic feedback’ as a viable behavior change strategy for enriching children’s early language environments through parental linguistic behaviors.
Epigenetics in the Eye: An Overview of the Most Relevant Ocular Diseases

Sight for mammals is one of the most appreciated senses. In humans there are several factors that contribute to the increment in all kind of eye diseases. This mini-review will focus on some diseases whose prevalence is steadily increasing year after year for non-genetic reasons, namely cataracts, dry eye, and glaucoma. Aging, diet, inflammation, drugs, oxidative stress, seasonal and circadian style-of-live changes are impacting on disease prevalence by epigenetics factors, defined as stable heritable traits that are not explained by changes in DNA sequence. The mini-review will concisely show the data showing epigenetics marks in these diseases and on how knowledge on the epigenetic alterations may guide therapeutic approaches to have a healthy eye.
Understanding Online Gaming Addiction and Treatment Issues for Adolescents

Massive Muti-user Online Role-Playing Games or MMORPGs as they are often called are one of the fastest growing forms of Internet addiction, especially among children and teenagers. Like an addiction to alcohol or drugs, gamers show several classic signs of addiction (Grusser, Thalemann, and Griffiths, 2007). They become preoccupied with gaming, lie about their gaming use, lose interest in other activities just to game, withdrawal from family and friends to game, and use gaming as a means of psychological escape (Leung, 2004). This paper explores the emergence of online gaming addiction and its impact on individuals and families. This paper reviews the nature of online games and what makes them addictive among some players. As computers are relied upon with greater frequency, detecting and diagnosing online gaming addiction may be difficult for clinicians, especially as symptoms of a possible problem may be masked by legitimate use of the Internet. This paper reviews the warning signs of online gaming addiction, adolescent issues involved in gaming addiction, especially as the industry targets youth, and parenting and therapy considerations for this emergent client population.
Levofloxacin and Tobramycin for Severe Bacterial Keratouveitis

Abstract Purpose: To report on clinical features and outcome of severe bacterial keratouveitis. Methods: Twenty patients with severe bacterial keratouveitis treated with topical tobramycin and levofloxacin and oral levofloxacin were included. Main outcome measures were ulcers location, bacterial isolates, risk factors, visual prognosis. Results: Centrally located ulcer/abscess was present in 65% of patients. Contact lens (CL) wear was the most common risk factor (70%). Bacterial isolates were observed in 58% of patients, none resistant to tobramycin and levofloxacin. Pseudomonas aeruginosa was found in 47% of positive cases and in 64% of CL wearers. After therapy, the mean visual acuity improved significantly (p < 0.0001), particularly in contact lens wearers (p = 0.04) and in patients younger than 60 years old (p < 0.001). Conclusions: Pseudomonas aeruginosa is the most frequent cause of bacterial keratouveitis and CL wear the most common risk factor. Topical tobramycin and levofloxacin and oral levofloxacin are effective in the treatment of bacterial keratouveitis.
Teaching to address diverse learning needs: development and validation of a Differentiated Instruction Scale

In the province of Quebec, Canada, a trend towards full inclusion has impelled teachers to adapt their instruction to meet the needs of both advanced and weaker learners in regular school settings. The main purpose of the present investigation was to develop and validate the Differentiated Instruction Scale (DIS), which assesses the use of instructional adaptations and academic progress monitoring strategies in general education classrooms. A total of 125 elementary school teachers participated in a cross-sectional study, allowing us to develop and validate the DIS. Overall our results show that the DIS is composed of two factors that are consistent with the predicted constructs (instructional adaptations and academic progress monitoring). Evidence of convergent validity is provided through correlations among DIS' subscales and two criteria: (1) teachers' autonomy support and (2) perceptions of school climate. Results also reveal that teachers tend to use instructional adaptations that do not require much preparation or tailored instruction. The DIS could thus be used in future research to investigate outcomes of differentiated instruction. Moreover, it could provide useful information on optimal strategies for promoting learning in children with different abilities in general education classrooms.
Hearing loss and auditory processing ability in people with aphasia

Background: Hearing loss can add to the linguistic deficits present in aphasia to make comprehension of speech difficult. Although some studies document a relatively high prevalence of hearing loss in adults with aphasia, many people with aphasia do not have their hearing tested. Self-reported disability measures offer a possible alternative to pure-tone audiometry when this service is not readily available. Aims: This study aims to investigate the prevalence of hearing loss in a group of people with aphasia and to determine the usefulness of self-reported measures to screen for hearing impairment. Methods & Procedures: Hearing ability was measured using pure-tone audiometry and five measures of auditory processing, which looked at speech perception in quiet and noise, for 21 individuals with aphasia recruited from a community clinic and 21 age-matched individuals without aphasia. The Speech, Spatial and Qualities of Hearing Scale (SSQ) and a brief questionnaire exploring whether they had experienced hearing difficulties were used to measure self-perception of hearing acuity. Differences in scores between the groups were analysed. Correlations and regressions were used to establish the relationship between self-perception of hearing and measures of hearing ability. Outcomes & Results: Despite minimal impairment and a non-significant difference between performance on pure-tone audiometry for participants with and without aphasia, participants with aphasia performed significantly worse on measures of speech perception in noise than participants without aphasia. They also had a significantly greater degree of perceived hearing disability. Although SSQ scores were correlated with some behavioural measures for the participants with aphasia, the SSQ only predicted the hearing status and speech in noise performance of control participants. Conclusions: The results suggest that the prevalence of hearing loss for people with aphasia (at least for this group) is no greater than the general population. However, they are significantly more affected in their recognition of speech in noise and experience greater disability in listening situations than people without aphasia. The latter problems were not predicted by pure-tone audiograms or sound-in-noise performance. The brief questionnaire was not effective in identifying hearing impairment, indicating the need for a regular hearing screen to ensure provision of the most effective rehabilitation. Ideally, the screen should include disability and behavioural measures, as our results suggest they cannot replace each other. These findings should assist clinicians in setting realistic goals and delivering interventions in the most effective way for people with aphasia.
PULSATING VARIABLE STARS IN THE COMA BERENICES DWARF SPHEROIDAL GALAXY

We present B, V, I time-series photometry of the Coma Berenices dwarf spheroidal galaxy, a faint Milky Way (MW) satellite, recently discovered by the Sloan Digital Sky Survey. We have obtained V, B − V and V, V − I color–magnitude diagrams that reach V ∼ 23.0-23.2 mag showing the galaxy turnoff at V ∼ 21.7 mag, and have performed the first study of the variable star population of this new MW companion. Two RR Lyrae stars (a fundamental-mode, RRab, and a first overtone, RRc, pulsator) and a short period variable with period P = 0.12468 days were identified in the galaxy. The RRab star has a rather long period of Pab = 0.66971 days and is about 0.2 mag brighter than the RRc variable and other nonvariable stars on the galaxy horizontal branch (HB). In the period–amplitude diagram, the RRab variable falls closer to the loci of Oosterhoff type-II systems and evolved fundamental-mode RR Lyrae stars in the Galactic globular cluster M3. The average apparent magnitude of the galaxy HB, 〈VHB〉 = 18.64 ± 0.04 mag, leads to a distance modulus for the Coma dSph μ0 = 18.13 ± 0.08 mag, corresponding to a distance d = 42+2−1 kpc, by adopting a reddening E(B − V) = 0.045 ± 0.015 mag and a metallicity [Fe/H] =−2.53 ± 0.05 dex.
Increase in Single L-Type Calcium Channels in Hippocampal Neurons During Aging

Voltage-activated calcium (Ca2+) influx is increased in mammalian CA1 hippocampal neurons during aging. However, the molecular basis for this elevation is not known. The partially dissociated hippocampal (“zipper'') slice preparation was used to analyze single Ca2+ channel activity in CA1 neurons of adult and aged rats. Total L-type Ca2+ channel activity in patches was found to increase with aging, primarily because of an increase in the density of functional channels. Learning in aged animals was inversely correlated with channel density. This increase in functional Ca2+ channels with aging could underlie the vulnerability of neurons to age-associated neurodegenerative conditions.
‘Indigenous Rights’ or ‘Racial Privileges’: The Rhetoric of ‘Race’ in New Zealand Politics

The New Zealand parliamentary election campaign of 2005 was marked by a significant break in the consensus between the two major political parties, Labour and National, in the area of Maori affairs: a consensus that had previously been articulated in terms of a shared commitment to ‘biculturalism’ and the Treaty of Waitangi. In January 2004, the National Party launched an attack on government policies, describing them as giving unfair privileges to Maori based purely on ‘race’. The present paper examines the National Party's adoption of the rhetoric of ‘race’ and the conceptual, political and ideological considerations behind it. It also examines attitudinal, social policy and socioeconomic factors to explain the widespread acceptability of this rhetoric among the New Zealand public. These events are considered within the context of a growing academic and political critique of ‘culturalism’ in New Zealand social policy and social science.
Rethinking Teacher Leadership Through Professional Development Schools

In this article, we trace possibilities for new forms of teacher leadership that are emerging in professional development schools (PDSs)-collaborations between schools and universities that have been created to support the learning of prospective and experienced teachers while simultaneously restructuring schools and schools of education. We examine data from in-depth case studies of seven PDSs, supplemented by research in a number of other professional development schools where similar patterns of teacher leadership have been noted. In our analysis of teacher leadership in professional development schools we make three claims: that teacher leadership is inextricably connected to teacher learning; that teacher leadership can be embedded in tasks and roles that do not create artificial, imposed, formal hierarchies, and that such approaches may lead to greater profession-wide leadership as the "normal" role of teacher is expanded, thereby improving the capacity of schools to respond to the needs of students.
Retinoid-induced suppression of squamous cell differentiation in human oral squamous cell carcinoma xenografts (line 1483) in athymic nude mice.

Retinoids are promising agents for therapy of squamous cancers. In vitro, retinoids decrease expression of differentiation markers in head and neck squamous carcinoma cells. Little information is available on effects of retinoids on head and neck squamous carcinoma cell xenograft growth in vivo. To address this issue, head and neck squamous carcinoma cells (line 1483) were established as xenografts in nude mice. Control tumors grew rapidly with doubling times of 4-6 days to mean volumes of 1696 mm3 after 24 days. Histological analyses indicated the formation of well-differentiated squamous carcinoma cells exhibiting pronounced stratification (basal and suprabasal cells) and keratinization (keratin pearls) with abundant stroma. Cytokeratin 19 expression was restricted to the basal cell layers, and cytokeratin 4 expression was abundant in suprabasal cells. Mice were treated daily with 30 mg/kg 9-cis retinoic acid, 20 mg/kg all-trans-retinoic acid, or 60 mg/kg 13-cis retinoic acid by p.o. gavage on a schedule of 5 days/week over 4 weeks. Low micromolar (1.48-3.67 microM) and nanomolar (200-490 nM) concentrations of 9-cis retinoic acid and all-trans-retinoic acid were measured in plasmas and xenografts, respectively, 30 min after dosing. Retinoid treatment produced a marked suppression of the squamous cell differentiation of tumor cells manifest by decreased keratinization, loss of stratification, and accumulation of basal cells. This was accompanied by large decreases in the number of CK4-positive cells and concomitant increases of CK19-positive cells. REtinoic acid receptor-beta expression was also increased by 2.9-9.7-fold after chronic retinoid treatment. 9-cis retinoic acid and all-trans-retinoic acid decreased tumor volumes by 23 +/- 5 (SE) and 19 +/- 3%, respectively (P < or = 0.05); 13-cis retinoic acid was inactive. These retinoids did not decrease the rate of exponential tumor growth but increased the latent period until exponential growth began. These studies demonstrate that retinoids do not universally decrease tumor growth but profoundly suppress squamous cell differentiation in vivo in this xenograft model.
The study of externalizing and internalizing behaviours in Greek, Russian, Indian, and Chinese children using the Fairy Tale Test

The present study investigated externalizing and internalizing behaviours in Greek (n = 599), Russian (n = 596), Indian (n = 571), and Chinese (n = 376) 7- to-12-year-old children. The Fairy Tale Test was used to measure impulsive and motivated aggression, fear of aggression, anxiety, and depression. The results indicated culture-specific patterns of the aforementioned behaviours. Greek children demonstrated the highest levels of impulsive and motivated aggression, while Russian children had the highest fear of aggression. Chinese children appeared to be most anxious among other cultural groups. Both Russian and Indian children were more depressed than their Greek and Chinese counterparts. Gender and age difference were obtained only for impulsive aggression. Regardless of culture, boys scored higher compared to girls; and 7- to 8-year-old children demonstrated higher level of impulsive aggression than older children. The obtained results are interpreted in light of contextual differences in child socialization in four cultures; suggestions for school psychology practices are offered.
Danish children's first words: Analysing longitudinal data based on monthly CDI parental reports

Using the Danish adaptation of the MacArthur-Bates Communicative Development Inventories (CDI), first language acquisition of 183 Danish children has been studied longitudinally on a monthly basis (8—30 months). Focussing on production, we study early lexical development from the very first word until roughly 100 words are produced, dividing this period into the stages of first-1, -10, -25, -50 and -100 words. We analyse Danish children's first words with respect to semantic-pragmatic content, sound structure, and composition of the early lexicon based on formal linguistic categories. Comparing Danish results crosslinguistically reveals both the overall typicality of Danish children's first words as well as striking differences for some single words.
Nonlinear Processes in Geophysics Internal solitary waves : propagation , deformation and disintegration

In coastal seas and straits, the interaction of barotropic tidal currents with the continental shelf, seamounts or sills is often observed to generate largeamplitude, horizontally propagating internal solitary waves. Typically these waves occur in regions of variable bottom topography, with the consequence that they are often modeled by nonlinear evolution equations of the Kortewegde Vries type with variable coefficients. We shall review how these models are used to describe the propagation, deformation and disintegration of internal solitary waves as they propagate over the continental shelf and slope.
Multi-word combinations and the emergence of differentiated ordering patterns in early trilingual development*

This study examines word order differentiation in early trilingual development through an analysis of the combinations produced by a Tagalog–Spanish–English trilingual child with an MLU of less than 1.5. Same- and mixed-language combinations were tracked down from diary data and weekly recordings to assess (i) whether word order significantly varied cross-linguistically, and (ii) whether mixed utterances originated from vocabulary gaps rather than from an undifferentiated syntax. The results indicate that (a) argument/predicate sequences were differentially ordered depending on their language and following input-dependent preferences, (b) mixed utterances were generally caused by vocabulary gaps, and (c) they displayed the same order as those single-language combinations produced in the same language context. These findings suggest that evidence for early word order differentiation can be found before the appearance of inflectional morphology and even when three – rather than two – languages are being acquired, indicating that trilingual exposure does not slow down the process of differentiation.
Conflicting Discourses in Qualitative Research

The search for disconfirming evidence, or negative cases, is often considered a valuable strategy for assessing the credibility or validity of qualitative research claims. This article draws on a multimethod qualitative research project to illustrate how a search for disconfirming evidence evolved from a check on the validity of findings to a strategy for revealing the multiple conflicting discourses within respondents’ narratives that transformed ambiguity into meaning. Reflecting on our study design and analytical process revealed multiple ways in which conflicting discourses were revealed. Field notes, research memoing, and comparison of findings across interview methods all contributed to the identification of conflicting discourses within narratives. The importance and relevance of the search for conflicting discourses for understanding meaning in qualitative research will be discussed.
Transcriptional activation by the human cytomegalovirus immediate-early proteins: requirements for simple promoter structures and interactions with multiple components of the transcription complex

We have utilized a number of well-defined, simple, synthetic promoters (upstream factor binding sites and TATA elements) to analyze the activation mechanisms of the human cytomegalovirus immediate-early (IE) proteins. We found that the 86-kDa IE protein (known as IEP86, IE2(559aa), or ppUL122a) can recognize and activate a variety of simple promoters, in agreement with the observation that it is a promiscuous activator. However, in the comparison of otherwise identical promoters IEP86 does have preferences for specific TATA elements (hsp70 > adenovirus E2 > simian virus 40 early) and specific upstream transcription factor binding sites (CAAT > SP1 approximately Tef-1 > ATF; no activation with AP1 or OCT). In contrast, the 72-kDa IE protein (known as IEP72, IE1(491aa), or ppUL123) alone did not significantly activate the simple promoters under our experimental conditions. However, each promoter activated by IEP86 was synergistically affected by the addition of IEP72. In addition, the 55-kDa IE protein (IEP55, a splice variant form of IE2, IE2(425aa), or ppUL122b) repeatedly had a negative effect, downregulating the activation of promoters caused by IEP86 and the synergy of IEP86 and IEP72. We show that the ability of IEP86 to activate many simple promoters correlates not only with its previously described ability to interact with the TATA-binding protein (TBP) (B. A. Furnari, E. Poma, T. F. Kowalik, S.-M. Huong, and E.-S. Huang, J. Virol. 67:4981-4991, 1993; C. Hagemeier, S. Walker, R. Caswell, T. Kouzarides, and J. Sinclair, J. Virol. 66:4452-4456, 1992; R. Jupp, S. Hoffman, R. M. Stenberg, J. A. Nelson, and P. Ghazal, J. Virol. 67:7539-7546, 1993) but also with its ability to interact with the transcription factors which bind to the upstream element of promoters it activated (e.g., SP1 and Tef-1 but not Oct-1). This ability to have multiple interactions with the promoter complex may be crucial for transcriptional activation, since the IE proteins cannot activate promoters having only a TATA element or only an upstream transcription factor binding site. In addition, we show that proteins which bind IEP86 also bind to IEP55. Thus, the negative effect on transcription noted with IEP55 may be the result of competition with IEP86 for interaction with the promoter complex. The synergy caused by IEP72 appears to be mediated by a more indirect mechanism. This is suggested by our observation that IEP72 could not bind to any of the proteins tested (TBP, Tef-1, or Oct-1) or to IEP86.
Whence Differences in Value Priorities?

To what extent do value priorities vary across countries and to what extent do individuals within countries share values? We address these questions using three sets of data that each measure values differently: the Schwartz Value Survey for student and teacher samples in 67 countries (N = 41,968), the Portrait Values Questionnaire for representative samples from 19 European countries (N = 42,359), and the World Value Survey for representative samples from 62 countries (N = 84,887). Analyses reveal more consensus than disagreement on value priorities across countries, refuting strong claims that culture determines values. Values associated with autonomy, relatedness, and competence show a universal pattern of high importance and high consensus. Only conformity values show patterns suggesting they are good candidates for measuring culture as shared meaning systems. We rule out reference-group and response style effects as alternative explanations for the results and discuss their implications for value theory, cross-cultural research, and value-based intergroup conflict.