Miracle-dz/UniFAR-FTUs huggingface dataset:
Prevalence of bruising at the vascular access site one week after elective cardiac catheterisation or percutaneous coronary intervention.

AIM To identify the prevalence and predictors of VAS bruising in the 5-7 days following cardiac catheterisation or percutaneous coronary intervention. BACKGROUND Complication(s) of cardiac catheterisation and/or percutaneous coronary intervention (PCI) occur commonly at the vascular access site (VAS). While major complications, such as retroperitoneal bleeding, are evident before hospital discharge, the prevalence of VAS bruising in the early post-discharge period is undocumented. DESIGN Prospective observational study. METHOD Data were collected on 172 patients following cardiac catheterisation and/or PCI through (1) chart review, (2) pre-discharge assessment and (3) telephone follow up 5-7 days post-discharge. RESULTS At the time of telephone follow up bruising was reported in 68.6% of all patients (n = 118), with 47% of those patients (n = 56) reporting bruises larger than 7.5 cm (3 inches). Incidence of bruising varied by access site; 73% of patients (n = 86) who had femoral access, 83% (n = 5) with femoral access plus closure device and 60% (n = 17) of patients with radial access reported bruising 5-7 days post-discharge. Bivariate analysis revealed a significant association between female sex and post discharge bruising (χ(2) 10.490, p = 0.001), with a likelihood ratio of 11.20. Abciximab use during the procedure was associated with post discharge bruising (Fisher's exact test, p = 0.045). Logistic regression analysis revealed female sex as a significant predictor of bruising after discharge (p = 0.001). CONCLUSION This study suggests that the majority of patients will experience significant bruising at the VAS following discharge and that women may be more at risk. RELEVANCE TO CLINICAL PRACTICE The high prevalence of post-discharge bruising after cardiac catheterisation and/or PCI has important implications for nursing education and preparation of patients prior to hospital discharge.
Expected poor responders on the basis of an antral follicle count do not benefit from a higher starting dose of gonadotrophins in IVF treatment: a randomized controlled trial.

BACKGROUND The aim of this study was to evaluate the effect of doubling the starting dose of gonadotrophins on the ovarian response in IVF patients with a low antral follicle count (AFC). METHODS Fifty-two patients with an AFC of <5 follicles of 2-5 mm diameter before starting their first IVF cycle participated in this randomized controlled trial. They were randomized by opening a sealed envelope, receiving either 150 IU (group I, n = 26) or 300 IU (group II, n = 26) of rFSH as a starting dose. The main outcome measures of the study were number of oocytes, poor response (<4 oocytes at retrieval or cancellation due to insufficient follicle growth) and ongoing pregnancy (12 weeks of gestation). RESULTS The groups were comparable regarding patient characteristics and outcome of the IVF treatment. The median number of oocytes collected was 3 for both groups (P = 0.79). The difference in the mean number of oocytes was 0.3 oocytes in favour of group I (P=0.69). Sixty-five per cent of the patients in group I experienced a poor response and 62% in group II. The ongoing pregnancy rate was 8% in group I and 4% in group II (P = 0.55). CONCLUSIONS Expected poor response patients, defined as patients with an AFC <5, are likely not to benefit from a higher starting dose of gonadotrophins in IVF.
Commentary: There is no demonstrable effect of desiccation

Everett, Blasi, and Roberts in their position paper (Everett et al. 2016, henceforth EBRPP) argue that the sound systems of human languages are ecologically adaptive on the grounds that, (1) human and animal behaviour is ‘generally’ adaptive and (2) that their previous work ‘supports’ the idea that ambient desiccation in the area where a language is spoken leads to the absence of lexical tone (EBRPP: 1). The first point is that it is more reasonable to expect a priori that sound systems of human languages are ecologically adaptive, than to expect the opposite. The authors boldly claim that ‘humans adapt to their ambient conditions at every observed level’ (EBRPP: 1) and follow the theoretical perspective with a number of examples of ecological adaptation from human and animal studies (EBRPP: 2–4). But somewhere here the logical jump from ‘some’ to ‘all’ was lost on the authors. If ecological adaptation can be found on some level it does not follow that sound systems of human languages belong to an adaptive level, or that all other levels are (or should be a priori expected to be) adaptive. To be fair, formulations later are weakened to ‘nearly every observed stratum’ (EBRPP: 1) and ‘nearly every inspected level’ (EBRPP: 2), but even that seems too strong. Should the water divider for a priori categorization not be whether the climatic differences can be argued to have a discernible impact on the human cultural behaviour in question? That is, the a priori question need not be determined by a general rule that stipulates everything to (not? ) adapt to climate, but by reasoning about the potential discernible impact given the theoretical specification of climatic differences and nature of some cultural behaviour. Had the authors approached ecological adaptivity in human language with this proviso in mind, they might …
Risk factors for aseptic loosening of Müller-type straight stems

Background and purpose Even small differences in design variables for the femoral stem may influence the outcome of a hip arthroplasty. We performed a risk factor analysis for aseptic loosening of 4 different versions of cemented Müller-type straight stems with special emphasis on design modifications (2 shapes, MSS or SL, and 2 materials, CoNiCrMo (Co) or Ti-6Al-7Nb (Ti)). Methods We investigated 828 total hip replacements, which were followed prospectively in our in-house register. All stems were operated in the same setup, using Sulfix-6 bone cement and a second-generation cementing technique. Demographic and design-specific risk factors were analyzed using an adjusted Cox regression model. Results The 4 versions showed marked differences in 15-year stem survival with aseptic loosening as the endpoint: 94% (95% CI: 89–99) for MSS Co, 83% (CI: 75–91) for SL Co, 81% (CI: 76–87) for MSS Ti and 63% (CI: 56–71) for SL Ti. Cox regression analysis showed a relative risk (RR) for aseptic loosening of 3 (CI: 2–5) for stems made of Ti and of 2 (CI: 1–2) for the SL design. The RR for aseptic stem loosening increased to 8 (CI: 4–15) when comparing the most and the least successful designs (MSS Co and SL Ti). Interpretation Cemented Müller-type straight stems should be MSS-shaped and made of a material with high flexural strength (e.g. cobalt-chrome). The surface finish should be polished (Ra < 0.4 µm). These technical aspects combined with modern cementing techniques would improve the survival of Müller-type straight stems. This may be true for all types of cemented stems.
A Model of Human Cooperation in Social Dilemmas

Social dilemmas are situations in which collective interests are at odds with private interests: pollution, depletion of natural resources, and intergroup conflicts, are at their core social dilemmas. Because of their multidisciplinarity and their importance, social dilemmas have been studied by economists, biologists, psychologists, sociologists, and political scientists. These studies typically explain tendency to cooperation by dividing people in proself and prosocial types, or appealing to forms of external control or, in iterated social dilemmas, to long-term strategies. But recent experiments have shown that cooperation is possible even in one-shot social dilemmas without forms of external control and the rate of cooperation typically depends on the payoffs. This makes impossible a predictive division between proself and prosocial people and proves that people have attitude to cooperation by nature. The key innovation of this article is in fact to postulate that humans have attitude to cooperation by nature and consequently they do not act a priori as single agents, as assumed by standard economic models, but they forecast how a social dilemma would evolve if they formed coalitions and then they act according to their most optimistic forecast. Formalizing this idea we propose the first predictive model of human cooperation able to organize a number of different experimental findings that are not explained by the standard model. We show also that the model makes satisfactorily accurate quantitative predictions of population average behavior in one-shot social dilemmas.
Evaluation of 60 continuous quality improvement projects in French hospitals.

OBJECTIVE To evaluate the feasibility of implementing continuous quality improvement (CQI) projects in French health care organizations. DESIGN The French Ministry of Health issued two calls for CQI projects (in 1995 and 1996). ANAES was commissioned to monitor and evaluate the projects, and to provide advice. SETTING ANAES in collaboration with French public hospitals. STUDY PARTICIPANTS A jury selected 64 projects from 483 submissions. The first series of projects related to safety issues (e.g. blood transfusions), the second related chiefly to patient management. INTERVENTIONS ANAES instructed project leaders in process analysis (modified four-step FOCUS-PDCA model), convened regular meetings between leaders and performed on-site visits. MAIN OUTCOME MEASUREMENTS Objective outcomes: goal achievement, extension of projects to other topics and departments, allocation of resources. Subjective outcomes: changes in attitudes. Statistics were obtained from two questionnaires completed by project leaders. RESULTS Four projects were discontinued; 82% (49 out of 60) met more than half their objectives. The CQI method was adopted by other departments in 65% and 50% (1st and 2nd series respectively) of cases. Hospital management often chose to provide continued support (81%/88%), offer training (59%/80%), create a CQI unit (62%/73%), and allocate a budget (61%/65%). A positive impact on staff attitudes was noted in over 75% of projects. CONCLUSION ANAES' co-ordinated initiative to acquaint a hard core of French public hospitals with CQI proved successful. Identification of the factors for success and of potential hurdles helped pave the way for the national hospital accreditation procedure currently underway.
The efficacy of setting process goals in orienting EFL learners to attend to the formal aspects of oral production

Breaking down and setting process goals have been shown to facilitate the learning of foreign/second language reading and writing. Whether the same goal-setting mechanism works as well in real-time EFL speaking tasks needs further investigation. This study explored the efficacy of setting form-focused process goals for EFL learners when they perform an oral communication task. Seventy-two college students were randomly paired within three experimental groups – form-focused, meaning-focused, and no goal – for a ten-minute communication task and their dialogues were transcribed and analyzed in terms of the quality (number of c-units, number of words per c-units, type-token ration, and error rates) and quantity (number of words and turn counts) of oral output. Statistical analyses indicated that setting a form-focused process goal did not make a difference when learners performed the oral task. The contradiction between this study and previous ones suggests that the dominance of product goals in real-time communication made explicit attention to form in the process difficult. In addition, level of learner involvement may have been lower when an explicit process goal was present.
DNA Barcoding Evaluation and Its Taxonomic Implications in the Recently Evolved Genus Oberonia Lindl. (Orchidaceae) in China

The orchid genus Oberonia Lindl. , is a taxonomically complex genus characterized by recent species radiations and many closely related species. All Oberonia species are under conservation as listed in the CITES and the IUCN Red List Categories and Criteria. Given its difficulties in taxonomy and conservation status, Oberonia is an excellent model for developing DNA barcodes. Three analytical methods and five DNA barcoding regions (rbcL, matK, trnH-psbA, ITS, and ITS2) were evaluated on 127 individuals representing 40 species and 1 variety of Oberonia from China. All the three plastid candidates tested (rbcL, matK, and trnH-psbA) have a lower discriminatory power than the nuclear regions (ITS and ITS2), and ITS had the highest resolution rate (82.14%). Two to four combinations of these gene sets were not better than the ITS alone, but when considering modes of inheritance, rbcL+ITS and matK+ITS were the best barcodes for identifying Oberonia species. Furthermore, the present barcoding system has many new insights in the current Oberonia taxonomy, such as correcting species identification, resolving taxonomic uncertainties, and the underlying presence of new or cryptic species in a genus with a complex speciation history.
Acceptability and Usability Evaluation of Finger-Stick Whole Blood HIV Self-Test as An HIV Screening Tool Adapted to The General Public in The Central African Republic

Background: Opportunities for HIV testing could be enhanced by offering HIV self-testing (HIVST) in populations that fear stigma and discrimination when accessing conventional HIV counselling and testing. Field experience with HIVST was poorly reported in French-speaking African countries. Objective: To investigate the usability of HIVST in Bangui, Central African Republic. Methods: The prototype self-test Exacto® Test HIV (Biosynex, Strasbourg, France) was used to assess the usability of HIVST in 300 adults living in Bangui, according to WHO technical recommendations. Simplified and easy-to-read leaflet was translated in French and Sango. Results: Preliminary survey in 3,484 adult volunteers including students, men who have sex with men and female sex workers living in Bangui showed that previous HIV testing in conventional centres for HIV counselling and testing was relatively infrequent and that acceptability of HIVST was elevated, although high heterogeneity could be observed between groups. The notice in French and Sango of Exacto® Test HIV were chosen in 242/300 (80.6%) and 58/300 (19.4%), respectively. It was correctly understood in 273/300 (91.0%). The majority (275/300; 91.6%) correctly performed the HIV self-test; however, 71/300 (23.0%) asked for oral assistance. Most of the participants (273/300; 91.0%) found that performing of the self-test was very easy or easy, and less than Most of participants (273/300; 91.0%) found that performing of the self-test was very easy or easy and less than 1.0% (2/300) found it difficult. Overall the result were correctly interpreted in 96.9% (3,782/3,900), the reading/interpretion errors concerned the positive (96/1,800;5.3%), invalid (17/600;2.8%) and negative (5/1,500; 0.3%) self-test. The Cohen's coefficient κwas 0.94. The main obstacle for HIVST was the educational level, with interpretation difficulties in poorly educated people. Conclusions: Our observations on profane adults living in Central African Republic, demonstrate: (i) the need to adapt the notice of instruction to African public, including educational pictograms as well as notice in vernacular language(s); (ii) the frequent difficulties in understanding the notice with frequent misinterpretation of test results; (iii) and the generally good usability of the HIV self-test despite these latter pitfalls. More research on exploring the best strategy (i.e. supervised versus unsupervised strategies) for different high- and low- risk populations in resource-constrained settings remains needed.
Spreading of methylation within RUNX3 CpG island in gastric cancer

RUNX3 is a novel tumor suppressor gene that is frequently silenced by promoter hypermethylation in gastric cancer. The methylation status of multiple regions within the RUNX3 promoter CpG island (3478 bp) was examined in gastric cancer cell lines, primary gastric cancers and non‐neoplastic gastric mucosa to clarify how methylation spreads within the CpG island. The critical regions for RUNX3 silencing were evaluated by analysis of cell lines. The most 5′ region of the CpG island was methylated in 90% (9/10) of gastric cancer cell lines, 96% (43/45) of primary gastric cancers and in 96% (43/45) of non‐neoplastic gastric mucosa. The frequencies of methylation were less near the transcription start site and were 40% (4/10) in cell lines, 53% (24/45) in primary gastric cancers and 11% (5/45) in non‐neoplastic gastric mucosa, where methylation was proven to be critical for gene silencing. Thus, hypermethylation initially occurs at the most 5′ region of the RUNX3 CpG island and spreads to the transcription start site before ultimately shutting down RUNX3 mRNA expression. The detection of hypermethylation at multiple regions within the RUNX3 CpG island may be useful in the diagnosis and risk assessment of gastric cancer. (Cancer Sci 2005)
Shaping Tactical Behaviours in Football: An Ecological Dynamics Approach.

XXI Chapter 1 – General Introduction 1 1.1 Defining tactical behaviours 3 1.2 Shaping tactical behaviours: Preview of the problem 4 1.3 An ecological dynamics account of tactical behaviour 6 1.3. 1 Constraints on tactical behaviours with special reference to instructional constraints 8 1.4 Structure and aims 10
Tissue Engineering and Regenerative Medicine Source of Stem Cells for Tissue Engineering and Regenerative Medicine

The exciting potential for regenerating organs from autologous stem cells is on the near horizon, and adult dermis stem cells (DSCs) are particularly appealing because of the ease and relative minimal invasiveness of skin collection. A substantial number of reports have described DSCs and their potential for regenerating tissues from mesenchymal, ectodermal, and endodermal lineages; however, the exact niches of these stem cells in various skin types and their antigenic surface makeup are not yet clearly defined. The multilineage potential of DSCs appears to be similar, despite great variability in isolation and in vitro propagation methods. Despite this great potential, only limited amounts of tissues and clinical applications for organ regeneration have been developed from DSCs. This review summarizes the literature on DSCs regarding their niches and the specific markers they express. The concept of the niches and the differentiation capacity of cells residing in them along particular lineages is discussed. Furthermore, the advantages and disadvantages of widely used methods to demonstrate lineage differentiation are considered. In addition, safety considerations and the most recent advancements in the field of tissue engineering and regeneration using DSCs are discussed. This review concludes with thoughts on how to prospectively approach engineering of tissues and organ regeneration using DSCs. Our expectation is that implementation of the major points highlighted in this review will lead to major advancements in the fields of regenerative medicine and tissue engineering. SIGNIFICANCE Autologous dermis-derived stem cells are generating great excitement and efforts in the field of re-generative medicine and tissue engineering. The substantial impact of this review lies in its critical coverage of the available literature and in providing insight regarding niches, characteristics, and isolation methods of stem cells derived from the human dermis. Furthermore, it provides analysis of the current state-of-the-art regenerative approaches using human-derived dermal stem cells, with consideration of current guidelines, to assist translation toward therapeutic use.
Active NaCl absorption across posterior gills of hyperosmoregulating Chasmagnathus granulatus

SUMMARY Split lamellae of posterior gills of Chasmagnathus granulatus adapted to 2.5‰ salinity were mounted in a modified Ussing chamber. With NaCl-saline on both sides of the preparation a transepithelial voltage (Vte) of 4.1±0.5 mV (outside positive) was measured. After voltage-clamping, the negative short-circuit current (Isc) amounted to -142±21 μA cm-2 at a conductance (Gte) of 44±5 mS cm-2. Substitution of either chloride (by nitrate) or sodium (by choline) on both sides of split gill lamellae significantly reduced Isc (by 70-80%) and Gte (by 30-50%). External CsCl (but not BaCl2 or furosemide) inhibited the negative Isc without affecting Gte. Addition of ouabain, BaCl2 or diphenylamine-2-carboxylate to the internal bath inhibited Isc at unchanged Gte. Internal acetazolamide did not affect Isc or Gte across split gill lamellae. Unidirectional Na+ influx across isolated and perfused posterior gills, however, was reduced by internal acetazolamide by approximately 20% at constant Vte. The results suggest that posterior gills of hyperosmoregulating C. granulatus display a high conductance epithelium that actively absorbs NaCl in a coupled way by an electrogenic mechanism similar to that seen in the thick ascending limb of Henle's loop and, to a minor degree, by an electroneutral mechanism, presumably via apical Na+/H+- and Cl-/HCO3--antiports.
COMPARING PUBLIC AND PRIVATE EMPLOYEES' JOB SATISFACTION AND TURNOVER INTENTION

This study compares the job satisfaction and turnover intentions of private- and public-sector employees in Serbia. Questionnaires were used to collect data from employees of various private enterprises and one public organization. The results show that the general job satisfaction and turnover intentions of public employees are different from those of private employees'. Public employees in Serbia have higher extrinsic job satisfaction and lower turnover intentions compared to their counterparts in the private sector. This satisfaction derived from interpersonal relationship, work organization and information within the organization. The reasons for this result can be fostering fundamental values national culture. Classifying the order culture with a high degree of collectivism, not surprising Serbian workers need to close and harmonious relationships with colleagues, especially need for information within the organization which reducing their uncertainty, insecurity and foster feelings of identification with the organization.
Industrial Information Technology Applications: Have Hospitality and Tourism Graduates Learned the Needed Skills?

Abstract Hospitality and tourism educators have been emphasizing that it is their goal to train their students with the skills that are required by the industry. While previous studies have demonstrated a varied degree of success for Hospitality & Tourism Management (HTM) education to achieve this goal, there exist no prior studies to investigate the relationship of information technology (IT) education and industrial applications in the Hong Kong context. This paper describes a study that examined the university HTM graduates' perceived importance levels of IT skills in the workplace and at the university. Empirical evidence showed that there exist significant differences in several dimensions of IT skills acquired at the university and required at work. Suggestions are provided accordingly for HTM educators in postsecondary education institutes to follow in order to eliminate the mismatches.