Miracle-dz/UniFAR-FTUs huggingface dataset:
Hepatitis C Virus Testing in Adults Living with HIV: A Need for Improved Screening Efforts

Objectives Guidelines recommend hepatitis C virus (HCV) screening for all people living with HIV (PLWH). Understanding HCV testing practices may improve compliance with guidelines and can help identify areas for future intervention. Methods We evaluated HCV screening and unnecessary repeat HCV testing in 8,590 PLWH initiating care at 12 U.S. HIV clinics between 2006 and 2010, with follow-up through 2011. Multivariable logistic regression examined the association between patient factors and the outcomes: HCV screening (≥1 HCV antibody tests during the study period) and unnecessary repeat HCV testing (≥1 HCV antibody tests in patients with a prior positive test result). Results Overall, 82% of patients were screened for HCV, 18% of those screened were HCV antibody-positive, and 40% of HCV antibody-positive patients had unnecessary repeat HCV testing. The likelihood of being screened for HCV increased as the number of outpatient visits rose (adjusted odds ratio 1.02, 95% confidence interval 1.01–1.03). Compared to men who have sex with men (MSM), patients with injection drug use (IDU) were less likely to be screened for HCV (0.63, 0.52–0.78); while individuals with Medicaid were more likely to be screened than those with private insurance (1.30, 1.04–1.62). Patients with heterosexual (1.78, 1.20–2.65) and IDU (1.58, 1.06–2.34) risk compared to MSM, and those with higher numbers of outpatient (1.03, 1.01–1.04) and inpatient (1.09, 1.01–1.19) visits were at greatest risk of unnecessary HCV testing. Conclusions Additional efforts to improve compliance with HCV testing guidelines are needed. Leveraging health information technology may increase HCV screening and reduce unnecessary testing.
Alp Rose stem cells, olive oil squalene and a natural alkyl polyglucoside emulsifier: Are they appropriate ingredients of skin moisturizers - in vivo efficacy on normal and sodium lauryl sulfate - irritated skin?.

Background/Aim Since skin moisturization may be achieved by both actives and chosen carrier, plant stem cells, squalene and natural alkyl polyglucoside emulsifier may be potential components of contemporary cosmetic products. The aim of the study was in vivo evaluation of the skin irritation potential and the efficacy of Alpine Rose stem cells incorporated into li-posomes and olive oil squalene as ingredients of moisturizing creams, with respect to the novel emulsifier used for creams’ stabilization. Methods With the employment of noninvasive skin biophysical measurements, skin hydration (EC), transepi-dermal water loss (TEWL), erythema index (EI) and viscoelas-ticity were measured on 76 healthy volunteers. In the first phase, skin irritation after a 24-hour occlusion and the long-term efficacy of creams (a 21-day study) on healthy skin were evaluated. Phase II of the study focused on the cream efficacy assessment after a 6-day treatment of sodium lauryl sulfate-irritated skin. Results After a 24-hour occlusion, there were no significant changes in the EI for any tested sample. In the second phase of the study, the EI was not significantly altered for the cream containing squalene, while the application of all active samples resulted in a significant reduction of TEWL. In both phases of the study an EC increase was recorded, espe-cially for the squalene-containing cream. Conclusion Due to the lack of skin irritation and skin barrier impairment along with the marked hydration effect, it could be said that the in-vestigated actives incorporated into alkyl polyglucoside emulsi-fier-stabilized creams may be safely applied as ingredients for "tailor-made" cosmetic moisturizers intended for normal and dry skin care, whereas olive oil squalene could be used for the treatment of irritated or sensitive skin as well. [Projekat Ministarstva nauke Republike Srbije, br. TR34031]
When Happy People Make Society Unhappy: Emotions Affect Compliance Behavior

Emotions have a strong impact on our everyday life, including our mental health, sleep pattern, overall well-being, and judgment and decision making. Our paper is the first study to show that incidental emotions, i.e., emotions not related to the actual choice problem, influence the compliance behavior of individuals. In particular, we provide evidence that individuals have a lower willingness to comply with social norms after being primed with positive incidental emotions compared with aversive emotions. This result is replicated in a second study. As an extension to our first study, we add a neutral condition as a control. Willingness to comply in this condition ranges between the other two conditions. Importantly, this finding indicates that the valence of an emotion but not its arousal drives the influence on compliance behavior. Furthermore, we show that priming with incidental emotions is only effective if individuals are - at least to some extent - emotionally sensitive.
Managing change: Seattle’s 21st century urban renaissance

ABSTRACT Evolution of the urban planning and historic preservation disciplines has resulted in an “uneasy alliance” in practice, one further complicated by the back-to-the-city movement and increased development pressure in older urban neighbourhoods. In Seattle, as in other U.S. cities, the pace, intensity and scale of redevelopment has caused dramatic spatial and social transformations. Although research has shown that older built fabric provides economic and social benefit for cities, neither regulations created by planners for guiding redevelopment nor strategies created by preservationists for retaining urban heritage have been successful in reconciling these different, yet interconnected, sets of values. We engage three Seattle neighbourhood case studies to clarify and evaluate policies, programs and strategies used by planners and preservationists for reimagining neighbourhood transformations. This work suggests a need for more creative, integrative collaboration between the two fields to simultaneously engage – and reconcile – social and economic tensions caused by urban redevelopment.
Rho Signaling Pathway Targeted to Promote Spinal Cord Repair

The Rho signaling pathway regulates the cytoskeleton and motility and plays an important role in neuronal growth inhibition. Here we demonstrate that inactivation of Rho or its downstream target Rho-associated kinase (ROK) stimulated neurite growth in primary cells of cortical neurons plated on myelin or chondroitin sulfate proteoglycan substrates. Furthermore, treatment either with C3 transferase (C3) to inactivate Rho or with Y27632 to inhibit ROK was sufficient to stimulate axon regeneration and recovery of hindlimb function after spinal cord injury (SCI) in adult mice. Injured mice were treated with a single injection of Rho or Rho-associated kinase inhibitors delivered in a protein adhesive at the lesion site. Treated animals showed long-distance regeneration of anterogradely labeled corticospinal axons and increased levels of GAP-43 mRNA in the motor cortex. Behaviorally, inactivation of Rho pathway induced rapid recovery of locomotion and progressive recuperation of forelimb–hindlimb coordination. These findings provide evidence that the Rho signaling pathway is a potential target for therapeutic interventions after spinal cord injury.
Exploring the Midgut Transcriptome and Brush Border Membrane Vesicle Proteome of the Rice Stem Borer, Chilo suppressalis (Walker)

The rice stem borer, Chilo suppressalis (Walker) (Lepidoptera: Pyralidae), is one of the most detrimental pests affecting rice crops. The use of Bacillus thuringiensis (Bt) toxins has been explored as a means to control this pest, but the potential for C. suppressalis to develop resistance to Bt toxins makes this approach problematic. Few C. suppressalis gene sequences are known, which makes in-depth study of gene function difficult. Herein, we sequenced the midgut transcriptome of the rice stem borer. In total, 37,040 contigs were obtained, with a mean size of 497 bp. As expected, the transcripts of C. suppressalis shared high similarity with arthropod genes. Gene ontology and KEGG analysis were used to classify the gene functions in C. suppressalis. Using the midgut transcriptome data, we conducted a proteome analysis to identify proteins expressed abundantly in the brush border membrane vesicles (BBMV). Of the 100 top abundant proteins that were excised and subjected to mass spectrometry analysis, 74 share high similarity with known proteins. Among these proteins, Western blot analysis showed that Aminopeptidase N and EH domain-containing protein have the binding activities with Bt-toxin Cry1Ac. These data provide invaluable information about the gene sequences of C. suppressalis and the proteins that bind with Cry1Ac.
Leisure Activity Patterns and Marital Conflict in Iran

Background: Over the past few decades, the association between leisure activity patterns and marital conflict or satisfaction has been studied extensively. However, most studies to date have been limited to middle-class families of developed societies, and an investigation of the issue, from a developing country perspective like Iran, is non-existent. Objectives: In an observational, analytical, cross-sectional study we aimed to investigate the relationship between leisure activity patterns and marital conflict in a nationally representative sample of Iranian married males. Patients and Methods: Using the cluster sampling method, a representative sample of 400 Iranian married individuals from seven provinces of Iran was surveyed. Self-administered surveys included a checklist collecting demographic and socioeconomic characteristics of the enrolled participants, leisure time questionnaire, and marital conflict questionnaire. The main patterns of leisure activity were derived from principal component analysis. For each pattern, factor scores were calculated. The relationship between factor scores and marital conflict were assessed using multivariate linear regression models accounting for the potential confounding effects of age, education, socioeconomic status, job status, number of children, duration of marriage, and time spent for leisure. Results: Two hundred and ninety-nine respondents completed the leisure time and marital conflict questionnaires. Five major leisure patterns were identified accounting for 60.3% of the variance in data. The most dominant pattern was family-oriented activities (e.g. spending time with family outdoors and spending time with family indoors) and was negatively linked to marital conflict (standardized beta= −0.154, P = 0.013). Of the four remaining patterns, three only included individual activities and one was a family-individual composite. Individual patterns exhibited discrepant behavior; while the pattern involving activities like ‘watching TV’, ‘non-purposive time spending’, and ‘napping’ was positively associated with conflict (standardized beta = 0.165, P = 0.009) and the other two were not. The mixed family-individual pattern was also positively associated with marital conflict (standardized beta = 0.240, P < 0.001). Conclusions: Among Iranian married men, family-based leisure activities are linked to a lower level of marital conflict. The associations for individual patterns are less congruent.
Silicosis and lung cancer: a mortality study of compensated men with silicosis in New South Wales, Australia.

BACKGROUND Lung cancer mortality has been found to be in excess in several groups with silicosis, but allowance for smoking was not always possible. We investigated the lung cancer mortality in men with silicosis in New South Wales, Australia, who were compensated, making allowance for smoking habits. METHODS A mortality study of 1467 men with silicosis in New South Wales who were compensated was carried out comparing observed mortality with that expected from the New South Wales death rates adjusting for age and period. Their smoking habits were compared with national survey smoking rates and the expected number of lung cancer deaths adjusted for smoking. Cases were coded for occupation and industry. RESULTS The observed mortality was higher than expected, but the only site of cancer showing a significant excess was the lung. The group with silicosis had smoked more than the national rates. After adjusting for smoking the standardized mortality ratio for lung cancer was 1.9 (95% confidence interval 1.5-2.3). Although there were differences in lung cancer mortality between industries and occupations, these differences were not statistically significant. CONCLUSIONS The excess lung cancer death rate may not be entirely due to silica exposure because compensation may have been influenced by the presence of chronic obstructive respiratory disease and there is some evidence that the presence of this disease increases lung cancer risk independently of smoking.
Having Less But Giving More: Work Experience and Prosocial Behavior of Chinese Working-Class Youth

Adolescent behavior is often negatively viewed especially regarding work experience. By introducing a concept of prosocial behavior, our study attempts to provide an alternative view on the effects of teenage job and work experience. We hypothesized that work experience could generate more prosocial behaviors. By surveying a large group of working-class youth (N = 2,860) from eight Chinese vocational schools and using structural equation modeling, we confirmed that the pattern of “having less, giving more” could be found in our sample. Our findings revealed that work experience could facilitate prosocial behavior via the increase of knowledge of both contract-based rights and labor action. By understanding working-class youth’s prosocial behavior as a positive outcome of work experience, this study calls for further research on other positive outcomes, such as cooperation, civic engagement, and solidarity, among working-class youth.
Quantifying the Regional Load-Bearing Ability of Trans-Tibial Stumps

This paper reports findings of experiments aiming to (1) compare the load tolerant ability over different regions of stumps of lower limb amputees, (2) study the effect of walking on the load tolerant ability, and (3) examine the distal-end weight-bearing ability supported by different interface materials. The method was to apply increasing load to the stump up to the pain level through a force transducer or a digital scale, considering the effect of regional difference, walking, and interface materials. The results show that the patellar tendon and the distal end of the fibula were the best and worst load-tolerant region, respectively. Walking with prostheses tended to increase the load-tolerant ability, which is thought to be due to the massage-like effect of the socket. Different interface materials did not significantly alter the distal-end weight-bearing ability. However, there was a great difference in the distal-end weight-bearing ability among different subjects.
Indicators to improve clinical quality across an integrated health care system.

PURPOSE To describe key historical and operational elements of change that may assist an organization to develop quality indicators for implementing a strategic plan to improve care, align health care improvement efforts with national directions, and examine the types of medication indicators used to assess these changes. SETTING The Baylor Health Care System (BHCS) is an integrated health care delivery organization in Dallas-Fort Worth, Texas. It includes 11 hospitals with 83 000 admissions per year and 47 primary care and senior centers with more than 500 000 visits annually. INTERVENTION Following a charter by the BHCS Board of Trustees to develop a health care quality improvement strategic plan, BHCS undertook a system-wide effort to improve care supported by the use of clinical quality indicators. RESULTS Consistent with the direction of the US Institute of Medicine, BHCS has implemented a clinical indicator system focused on measures of health care underuse, overuse, and misuse. These indicators demonstrated the accomplishments of specific process of care improvements throughout BHCS. Despite implementing Web-enabled error reporting systems and pilot work with an adverse drug event hospital medical record abstraction tool, BHCS indicators of medication misuse continue to be in a formative stage, much like the national consensus. CONCLUSION Organizational, compensatory, and cultural commitments may be important for successful implementation of clinical indicator initiatives by health care systems. Using clinical indicators to establish baseline performance and to assess the effectiveness of proposed quality improvements provides quantitative and qualitative means to identify and disseminate best care practices. Although indicators to measure underuse of clinically necessary care are well established, there remains a need to achieve consensus regarding practicable medication quality indicators for overuse, misuse, and adverse drug events.
Fragmented Romanian Sociology: Growth and Structure of the Collaboration Network

Structural patterns in collaboration networks are essential for understanding how new ideas, research practices, innovation or cooperation circulate and develop within academic communities and between and within university departments. In our research, we explore and investigate the structure of the collaboration network formed by the academics working full-time within all the 17 sociology departments across Romania. We show that the collaboration network is sparse and fragmented, and that it constitutes an environment that does not promote the circulation of new ideas and innovation within the field. Although recent years have witnessed an increase in the productivity of Romanian sociologists, there is still ample room for improvement in terms of the interaction infrastructure that ought to link individuals together so that they could maximize their potentials. We also fail to discern evidence in favor of the Matthew effect governing the growth of the network, which suggests scientific success and productivity are not rewarded. Instead, the structural properties of the collaboration network are partly those of a core-periphery network, where the spread of innovation and change can be explained by structural equivalence rather than by interpersonal influence models. We also provide support for the idea that, within the observed network, collaboration is the product of homophily rather than prestige effects. Further research on the subject based on data from other countries in the region is needed to place our results in a comparative framework, in particular to discern whether the behavior of the Romanian sociologist community is unique or rather common.
Distributed Control for Charging Multiple Electric Vehicles with Overload Limitation

Severe pollution induced by traditional fossil fuels arouses great attention on the usage of plug-in electric vehicles (PEVs) and renewable energy. However, large-scale penetration of PEVs combined with other kinds of appliances tends to cause excessive or even disastrous burden on the power grid, especially during peak hours. This paper focuses on the scheduling of PEVs charging process among different charging stations and each station can be supplied by both renewable energy generators and a distribution network. The distribution network also powers some uncontrollable loads. In order to minimize the on-grid energy cost with local renewable energy and non-ideal storage while avoiding the overload risk of the distribution network, an online algorithm consisting of scheduling the charging of PEVs and energy management of charging stations is developed based on Lyapunov optimization and Lagrange dual decomposition techniques. The algorithm can satisfy the random charging requests from PEVs with provable performance. Simulation results with real data demonstrate that the proposed algorithm can decrease the time-average cost of stations while avoiding overload in the distribution network in the presence of random uncontrollable loads.
BRAF-activated long non-coding RNA contributes to cell proliferation and activates autophagy in papillary thyroid carcinoma

Long non-coding RNAs (lncRNAs) are novel regulators in cancer biology. BRAF-activated lncRNA (BANCR) is overexpressed in melanoma and has a potential functional role in melanoma cell migration. However, little is known about the role of BANCR in the development of papillary thyroid carcinoma (PTC). In the present study, BANCR expression was examined in six pairs of PTC and matched adjacent normal tissues. The results revealed that BANCR levels were significantly higher in the PTC tissues and PTC IHH-4 cells compared with the normal controls. Knockdown of BANCR in the IHH-4 cells inhibited proliferation and increased apoptosis of the cells in vitro. Further investigation of the underlying mechanisms revealed that BANCR markedly activated autophagy. Overexpression of BANCR inhibited apoptosis in the IHH-4 cells, whereas inhibition of autophagy stimulated apoptosis in the BANCR-overexpressed cells. BANCR overexpression also increased cell proliferation and the inhibition of autophagy abrogated BANCR overexpression-induced cell proliferation. In addition, the overexpression of BANCR resulted in an increase in the ratio of LC3-II/LC3-I, a marker for autophagy, while the knockdown of BANCR decreased the ratio of LC3-II/LC3-I. These results revealed that BANCR expression levels are upregulated in PTC. Additionally, BANCR increases PTC cell proliferation, which could activate autophagy.
The Communicative Constitution of Collective Identity in Interorganizational Collaboration

This study reconceptualizes collective identity from a communication perspective using a constitutive model of communication as a theoretical framework. A longitudinal case study is used to explain the complications and inaction of a social services interorganizational collaboration as a lack of collective identity, also tracing the emergence of a new collective identity. Collective identity is theorized as an authoritative text that emerges through communicative practice and is drawn on for certain strategic ends. A communicative model of organizational constitution—based on the ‘Montreal School’ theory of coorientation—shows how textual representations of situated conversations can gain authority through abstraction and reification, providing a mechanism to organize and direct the voluntary actions of diverse stakeholders. Implications for theory and research are discussed.
The Role of Immune System in Depression Disorder

In order to diagnose a major depressive disorder, patients must have at least 5 depres-sive symptoms out of 9 criteria, present for at least two weeks. Depressive symptoms include absence of concentration, fatigue and suicidal ideation. The intensity of de-pression symptoms affects the severity of depression and the degree of the impact on the quality of life. Major depressive disorders (MDD) are defined as a significant health problem, and are estimated to rise in prevalence in the future years. Immune cytokine, associated with major depression for instance, is the interleukin IL-6 and tu-mor necrosis factor (TNF-α) which is defined as pro-inflammatory cytokines, can ac-tivate an inflammatory response. The effects of other inflammatory cytokines on the central nervous system are of controversy. There is an increasing interest about the ef-fect of cytokines derived from innate immune system on the brain and behavior. Cytokines are defined as large sized proteins, mainly produced by immune cells. Two subtypes of cytokines exist: pro-inflammatory cytokines, facilitating inflammatory re-sponses and neural activities; and anti-inflammatory cytokines, inhibiting inflammatory processes. Besides microglia and astrocytes, immune cells such as monocytes, macrophages, and lymphocytes also produce cytokines. At the times of immunological alterations, infections or inflammation, cytokines will be in an activated form. The main goal of the current review study is to investigate the role of the immune system in the depression disorder.