Miracle-dz/UniFAR-FTUs huggingface dataset:
Palliative Effects of an Incomplete Cytoreduction Combined With Perioperative Intraperitoneal Chemotherapy

Objectives:Incomplete cytoreduction often occurs because of overwhelming burden of disease intraperitoneally that limit a successful cytoreduction. The outcome of an incomplete cytoreduction followed by administering perioperative intraperitoneal chemotherapy on whether it prolongs survival or palliates symptoms is yet to be established. Methods:A retrospective review of a prospectively collected database was performed. Eleven patients were identified to have had an incomplete (CC2/3) cytoreduction and received either hyperthermic intraperitoneal chemotherapy or early postoperative intraperitoneal chemotherapy. The symptoms of the patients before and after treatment during follow-up consultations in clinic were noted. Survival analysis was performed using the Kaplan Meier method. Results:The median follow-up period was 19 (range, 0.5–35) months. The overall median survival was 21 months with a 1- and 2-year survival rate of 72% and 36%, respectively. Five of 7 patients with pseudomyxoma peritonei and 2 of 3 patients with colorectal cancer peritoneal carcinomatosis experienced symptom improvement after treatment. Severe postoperative morbidity and achieving symptomatic improvement following treatment seems to be associated with a dismal prognosis. Conclusion:Our results suggest that some patients derive a survival and symptomatic benefits despite an incomplete cytoreductive surgery and perioperative intraperitoneal chemotherapy. The effects of this treatment require further investigation to determine its benefits as a palliative procedure.
Astrocytes, an active player in Aicardi–Goutières syndrome

Aicardi–Goutières syndrome (AGS) is an early‐onset, autoimmune and genetically heterogeneous disorder with severe neurologic injury. Molecular studies have established that autosomal recessive mutations in one of the following genes are causative: TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, ADAR1 and IFIH1/MDA5. The phenotypic presentation and pathophysiology of AGS is associated with over‐production of the cytokine Interferon–alpha (IFN‐α) and its downstream signaling, characterized as type I interferonopathy. Astrocytes are one of the major source of IFN in the central nervous system (CNS) and it is proposed that they could be key players in AGS pathology. Astrocytes are the most ubiquitous glial cell in the CNS and perform a number of crucial and complex functions ranging from formation of blood‐brain barrier, maintaining ionic homeostasis, metabolic support to synapse formation and elimination in healthy CNS. Involvement of astrocytic dysfunction in neurological diseases—Alexander's disease, Epilepsy, Alzheimer's and amyotrophic lateral sclerosis (ALS)—has been well‐established. It is now known that compromised astrocytic function can contribute to CNS abnormalities and severe neurodegeneration, nevertheless, its contribution in AGS is unclear. The current review discusses known molecular and cellular pathways for AGS mutations and how it stimulates IFN‐α signaling. We shed light on how astrocytes might be key players in the phenotypic presentations of AGS and emphasize the cell‐autonomous and non‐cell‐autonomous role of astrocytes. Understanding the contribution of astrocytes will help reveal mechanisms underlying interferonopathy and develop targeted astrocyte specific therapeutic treatments in AGS.
Anticipation by multi-modal association through an artificial mental imagery process

Mental imagery has become a central issue in research laboratories seeking to emulate basic cognitive abilities in artificial agents. In this work, we propose a computational model to produce an anticipatory behaviour by means of a multi-modal off-line hebbian association. Unlike the current state of the art, we propose to apply hebbian learning during an internal sensorimotor simulation, emulating a process of mental imagery. We associate visual and tactile stimuli re-enacted by a long-term predictive simulation chain motivated by covert actions. As a result, we obtain a neural network which provides a robot with a mechanism to produce a visually conditioned obstacle avoidance behaviour. We developed our system in a physical Pioneer 3-DX robot and realised two experiments. In the first experiment we test our model on one individual navigating in two different mazes. In the second experiment we assess the robustness of the model by testing in a single environment five individuals trained under different conditions. We believe that our work offers an underpinning mechanism in cognitive robotics for the study of motor control strategies based on internal simulations. These strategies can be seen analogous to the mental imagery process known in humans, opening thus interesting pathways to the construction of upper-level grounded cognitive abilities.
ATTACHMENT STYLE AND CHRONIC PAIN SYNDROME: THE IMPORTANCE OF PSYCHOLOGICAL AND SOCIAL VARIABLES IN THE BIOPSYCHOSOCIAL MODEL OF CHRONIC PAIN

The current research examined the proposition that individuals who were securely attached had a fundamentally different reaction and experience of chronic pain to the experience of individuals with an insecure attachment style. A biopsychosocial model of chronic pain was created that included the variables of attachment style, pain, depression, anxiety, somatisation, quality of life, function, disability, neuroticism, age and gender. Three cross-sectional quantitative studies and one qualitative study were conducted. Participants were (a) patients from a multidisciplinary pain centre in a major public hospital, and (b) members of the general population with chronic pain who were recruited from both urban and rural settings, across various community support groups. The total sample was 470. Instruments for the quantitative studies included the Revised Adult Attachment Scale (Collins & Read, 1990), the McGill Pain Questionnaire (Melzack, 1975), the Pain Patient Profile (Tollinson & Langley, 1992), the Quality of Life Inventory (Frisch, 1994), the International Association for the Study of Pain Assessment Protocol (International Association for the Study of Pain, 1986), the Migraine Disability Scale (Stewart, Lipton, Kolodner, Liebermann, & Sawyer, 1999), and the short form of the Eysenck Neuroticism Scale (Eysenck, Eysenck, & Barret, 1985). The clinical and non-clinical participants with a diagnosis of chronic pain syndrome were partitioned as securely or insecurely attached. In the clinical sample, the proportion of securely attached individuals was less than one quarter of the group, while in the nonclinical sample the proportion of individuals in the securely attached group was 50%. For Study 1, (200 individuals from the clinical sample), the groups were partitioned using the classification criteria of Collins and Read (1990). Securely attached participants = 27%, insecurely attached 73%. An analysis of effect of attachment style on overall pain showed
Alexander disease: an astrocytopathy that produces a leukodystrophy

Alexander Disease (AxD) is a degenerative disorder caused by mutations in the GFAP gene, which encodes the major intermediate filament of astrocytes. As other cells in the CNS do not express GFAP, AxD is a primary astrocyte disease. Astrocytes acquire a large number of pathological features, including changes in morphology, the loss or diminution of a number of critical astrocyte functions and the activation of cell stress and inflammatory pathways. AxD is also characterized by white matter degeneration, a pathology that has led it to be included in the “leukodystrophies. ” Furthermore, variable degrees of neuronal loss take place. Thus, the astrocyte pathology triggers alterations in other cell types. Here, we will review the neuropathology of AxD and discuss how a disease of astrocytes can lead to severe pathologies in non‐astrocytic cells. Our knowledge of the pathophysiology of AxD will also lead to a better understanding of how astrocytes interact with other CNS cells and how astrocytes in the gliosis that accompanies many neurological disorders can damage the function and survival of other cells.
Design and protocol of Estrogenic Regulation of Muscle Apoptosis (ERMA) study with 47 to 55-year-old women's cohort: novel results show menopause-related differences in blood count

Objective: The multidisciplinary Estrogenic Regulation of Muscle Apoptosis (ERMA) study was designed to reveal how hormonal differences over the menopausal stages affect the physiological and psychological functioning of middle-aged women. This paper describes the protocol and nonrespondent analysis of ERMA and novel findings on menopausal differences in blood count variables and their association with female sex hormones. Methods: Women aged 47 to 55 years were assigned to pre, early peri, late peri, and postmenopausal groups based on follicle-stimulating hormone (FSH) and bleeding diary. Multivariate linear regression models were constructed to estimate the association of 17&bgr;-estradiol (E2) and FSH with the blood count variables. Results: In all, 3,064 women returned the prequestionnaire (ERMA phase one), 1,393 donated blood samples and were assigned to the relevant menopausal group (phase two), and 914 completed phase three, which included physiological and psychological measurements. Nonrespondents were more likely than respondents to be obese, whereas the menopausal groups showed no mean differences in body mass index. Blood count variables, while being within clinical reference values, showed significant differences between groups. E2 and FSH were associated with the white blood cell (WBC) count and neutrophil-to-lymphocyte ratio. Conclusions: The ERMA study was successful in recruiting and characterizing the menopausal status of a cohort sample of middle-aged women. The significant group differences found in the blood count variables and their associations with E2 and FSH verifies menopause-associated changes in WBC composition potentially being an early sign of low-grade inflammation that may develop later in life.
Availability of iron and major nutrients for phytoplankton in the northeast Atlantic Ocean

Because of recent findings that Fe is a limiting factor for phytoplankton activity even at relatively high dissolved iron (DFe) concentrations, the potential importance of Fe limitation was revisited in the northeast Atlantic Ocean (39−45°N, 17−21°W). We report data gathered during deck incubation experiments performed at three stations in February‐March 2001 with surface seawater containing DFe concentrations of ~0.40 nmol L−1. At all stations, Fe addition enhanced phytoplankton growth. Fe limitation was moderate and occurred simultaneously with limitation by major nutrients. This was clearly demonstrated for diatoms that were colimited by orthosilicic acid. Micro‐, nano‐, and picoplankton benefited from Fe enrichment. Experiments performed with the trihydroxamate siderophore desferrioxamine mesylate B (DFOB) indicated that Fe reserves exist within the cells, especially within the larger cells. This reserve could result from luxurious storage of Fe by colimited cells during episodic atmospheric deposition of Saharan dust. Simulating concentrations of dust resulting from aerosol deposition in well‐stratified surface waters, we determined that the solubility of Saharan dust was very low (<0.1% w/w) but the amount of DFe released in seawater was sufficient to relieve the Fe limitation of the ambient phytoplankton community.
From Word to Sense Embeddings: A Survey on Vector Representations of Meaning

Over the past years, distributed semantic representations have proved to be effective and flexible keepers of prior knowledge to be integrated into downstream applications. This survey focuses on the representation of meaning. We start from the theoretical background behind word vector space models and highlight one of their major limitations: the meaning conflation deficiency, which arises from representing a word with all its possible meanings as a single vector. Then, we explain how this deficiency can be addressed through a transition from the word level to the more fine-grained level of word senses (in its broader acceptation) as a method for modelling unambiguous lexical meaning. We present a comprehensive overview of the wide range of techniques in the two main branches of sense representation, i.e., unsupervised and knowledge-based. Finally, this survey covers the main evaluation procedures and applications for this type of representation, and provides an analysis of four of its important aspects: interpretability, sense granularity, adaptability to different domains and compositionality.
An Analysis of Genetic Diversity Across the Maize Genome Using Microsatellites

How domestication bottlenecks and artificial selection shaped the amount and distribution of genetic variation in the genomes of modern crops is poorly understood. We analyzed diversity at 462 simple sequence repeats (SSRs) or microsatellites spread throughout the maize genome and compared the diversity observed at these SSRs in maize to that observed in its wild progenitor, teosinte. The results reveal a modest genome-wide deficit of diversity in maize relative to teosinte. The relative deficit of diversity is less for SSRs with dinucleotide repeat motifs than for SSRs with repeat motifs of more than two nucleotides, suggesting that the former with their higher mutation rate have partially recovered from the domestication bottleneck. We analyzed the relationship between SSR diversity and proximity to QTL for domestication traits and observed no relationship between these factors. However, we did observe a weak, although significant, spatial correlation for diversity statistics among SSRs within 2 cM of one another, suggesting that SSR diversity is weakly patterned across the genome. Twenty-four of 462 SSRs (5%) show some evidence of positive selection in maize under multiple tests. Overall, the pattern of genetic diversity at maize SSRs can be explained largely by a bottleneck effect with a smaller effect from selection.
Early Cerebral Vein After Endovascular Ischemic Stroke Treatment Predicts Symptomatic Reperfusion Hemorrhage

Background and Purpose— Parenchymal hemorrhage (PH) after endovascular mechanical thrombectomy in acute ischemic stroke leads to worse outcomes. Better clinical and imaging biomarkers of symptomatic reperfusion PH are needed to identify patients at risk. We identified clinical and imaging predictors of reperfusion PH after endovascular mechanical thrombectomy with attention to early cerebral veins (ECVs) on postreperfusion digital subtraction angiography. Methods— We performed a retrospective cohort study of consecutive acute ischemic stroke patients undergoing endovascular mechanical thrombectomy at our neurovascular referral center. Clinical and imaging characteristics were collected from patient health records, and random forest variable importance measures were used to identify predictors of symptomatic PH. Predictors of secondary outcomes, including 90-day mortality, functional dependence (modified Rankin Scale score, >2), and National Institutes of Health Stroke Scale shift, were also determined. Diagnostic test characteristics of ECV for symptomatic PH were determined using a receiver operating characteristic analysis. Differences between patients with and without symptomatic PH were assessed with Fisher exact test and the Wilcoxon rank sum (Mann–Whitney U test) test at the 0.05 significance level. Results— Of 64 patients with anterior circulation large-vessel occlusion identified, 6 (9.4%) developed symptomatic PH. ECV was the strongest predictor of symptomatic PH with more than twice the importance of the next best predictor, male sex. Although ECV was also predictive of 90-day mortality and functional dependence, other characteristics were more important than ECV for these outcomes. The sensitivity and specificity of ECV alone for subsequent hemorrhage were both 0.83, with an area under the curve of 0.83 and 95% confidence interval of 0.66 to 1.00. Conclusions— ECV on postendovascular mechanical thrombectomy digital subtraction angiography is highly diagnostic of subsequent symptomatic reperfusion hemorrhage in this data set. This finding has important implications for post-treatment management of blood pressure and anticoagulation.
Caring as a collective knowledgeable doing: About concern and being concerned

Care is not an innate human capacity; rather, it is an organizational competence, a situated knowing that a group of professionals enact while attending to their everyday tasks. We propose a post-humanist practice approach to reading care as a matter of concern for those producing care and for society at large. Care is framed as a collective knowledgeable ‘doing’, it is not an object or a quality that is added to work; rather, it is ‘caring’, an ongoing sociomaterial accomplishment. Through an ethnography in a nursing home for the elderly, we describe: (a) how caring was collectively performed in keeping a common orientation, (b) how caring was inscribed in a texture of practices, and (c) how a technological change in nutrition practice mobilized ethics as practice in situated decision-making. Since natural nutrition is being increasingly replaced by artificial feeding, we describe how the collective and organizational ethic of care with tube feeding is talked about in practice, in a front-stage situation and in the back-stage one. In this process, the duality of care as a matter of concern and as the process of being concerned by caring becomes visible.
GPs' understanding and practice of safety netting for potential cancer presentations: a qualitative study in primary care.

BACKGROUND Safety netting is a diagnostic strategy used in UK primary care to ensure patients are monitored until their symptoms or signs are explained. Despite being recommended in cancer diagnosis guidelines, little evidence exists about which components are effective and feasible in modern-day primary care. AIM To understand the reality of safety netting for cancer in contemporary primary care. DESIGN AND SETTING A qualitative study of GPs in Oxfordshire primary care. METHOD In-depth interviews with a purposive sample of 25 qualified GPs were undertaken. Interviews were recorded and transcribed verbatim, and analysed thematically using constant comparison. RESULTS GPs revealed uncertainty about which aspects of clinical practice are considered safety netting. They use bespoke personal strategies, often developed from past mistakes, without knowledge of their colleagues' practice. Safety netting varied according to the perceived risk of cancer, the perceived reliability of each patient to follow advice, GP working patterns, and time pressures. Increasing workload, short appointments, and a reluctance to overburden hospital systems or create unnecessary patient anxiety have together led to a strategy of selective active follow-up of patients perceived to be at higher risk of cancer or less able to act autonomously. This left patients with low-risk-but-not-no-risk symptoms of cancer with less robust or absent safety netting. CONCLUSION GPs would benefit from clearer guidance on which aspects of clinical practice contribute to effective safety netting for cancer. Practice systems that enable active follow-up of patients with low-risk-but-not-no-risk symptoms, which could represent malignancy, could reduce delays in cancer diagnosis without increasing GP workload.
Psychometric Evaluation of the Chinese Version of the Emotion Regulation Questionnaire in Taiwanese College Students

Emotion regulation has been considered a vital mechanism for psychological and physical health. The Emotion Regulation Questionnaire (ERQ) was originally developed by Gross and John to measure the emotion regulation strategies of cognitive reappraisal and expressive suppression. Given the practical importance of functional emotion regulation for psychological assessment in the Taiwanese cultural context, this study examined the psychometric properties of the Chinese version of the ERQ in a sample of 909 Taiwanese college students. Results showed that the independent two-factor measurement model was an adequate representation of the structure of the Chinese-ERQ. Reliability and criterion validity of the Chinese-ERQ were also demonstrated. The scalar invariant model across genders was supported and male students reported using suppression to a greater degree than female students. Overall, the Chinese-ERQ is a valuable tool for assessing emotion regulation strategies in research and practice in clinical psychology. Practical implications and future research directions are discussed.
Application of spectral analysis techniques in the intercomparison of aerosol data. Part II: Using maximum covariance analysis to effectively compare spatiotemporal variability of satellite and AERONET measured aerosol optical depth

Moderate Resolution Imaging SpectroRadiometer (MODIS) and Multi‐angle Imaging Spectroradiomater (MISR) provide regular aerosol observations with global coverage. It is essential to examine the coherency between space‐ and ground‐measured aerosol parameters in representing aerosol spatial and temporal variability, especially in the climate forcing and model validation context. In this paper, we introduce Maximum Covariance Analysis (MCA), also known as Singular Value Decomposition analysis as an effective way to compare correlated aerosol spatial and temporal patterns between satellite measurements and AERONET data. This technique not only successfully extracts the variability of major aerosol regimes but also allows the simultaneous examination of the aerosol variability both spatially and temporally. More importantly, it well accommodates the sparsely distributed AERONET data, for which other spectral decomposition methods, such as Principal Component Analysis, do not yield satisfactory results. The comparison shows overall good agreement between MODIS/MISR and AERONET AOD variability. The correlations between the first three modes of MCA results for both MODIS/AERONET and MISR/AERONET are above 0.8 for the full data set and above 0.75 for the AOD anomaly data. The correlations between MODIS and MISR modes are also quite high (> 0.9). We also examine the extent of spatial agreement between satellite and AERONET AOD data at the selected stations. Some sites with disagreements in the MCA results, such as Kanpur, also have low spatial coherency. This should be associated partly with high AOD spatial variability and partly with uncertainties in satellite retrievals due to the seasonally varying aerosol types and surface properties.
The Ego-Defensive Role of Legitimacy: How Threat-Based Justifications Protect the Self-Esteem of Discriminators

This article analyzes the ego-defensive role played by legitimation, by examining the hypothesis that threat-based justifications attenuate the negative effect on an individual’s self-esteem caused by his or her becoming aware of his or her own discriminatory behavior. Across three studies (including a pilot experiment), participants who were led to believe that they had acted in a discriminatory way experienced a decrease in their self-esteem. In Study 1 (N = 116), this effect was nullified when discrimination was justified by either symbolic or realistic threat perceptions. Study 2 (N = 250) replicated this pattern of results and went further by showing that discrimination affects self-esteem only in more egalitarian individuals, whereas for those less egalitarian, it affects their social image. According to the ego-defensive role of legitimation, a meta-analytical integration of the results confirmed that the influence of discrimination in depressing self-esteem is moderated by threat-based justifications.