Miracle-dz/UniFAR-FTUs huggingface dataset:
Developing a model of embedding academic numeracy in university programs : a case study from nursing

This is a study of the academic numeracy of nursing students. This study develops a theoretical model for the design and delivery of university courses in academic numeracy. The following objectives are addressed: 1. To investigate nursing students' current knowledge of academic numeracy; 2. To investigate how nursing students’ knowledge and skills in academic numeracy can be enhanced using a developmental psychology framework; and 3. To utilise data derived from meeting objectives 1 and 2 to develop a theoretical model to embed academic numeracy in university programs. This study draws from Valsiner’s Human Development Theory (Valsiner, 1997, 2007). It is a quasi-experimental intervention case study (Faltis, 1997) and takes a multimethod approach using pre- and post-tests; observation notes; and semi-structured teaching sessions to document a series of microgenetic studies of student numeracy. Each microgenetic study is centered on the lived experience of students becoming more numerate. The method for this section is based on Vygotsky’s double stimulation (Valsiner, 2000a; 2007). Data collection includes interviews on students’ past experience with mathematics; their present feelings and experiences and how these present feelings and experiences are transformed. The findings from this study have provided evidence that the course developed for nursing students, underpinned by an appropriate framework, does improve academic numeracy. More specifically, students improved their content knowledge of and confidence in mathematics in areas that were directly related to their degree. The study used Valsiner’s microgenetic approach to development to trace the course as it was being taught and two students’ personal academic numeracy journeys. It highlighted particularly troublesome concepts, then outlined scaffolding and pathways used to develop understanding. This approach to academic numeracy development was summarised into a four-faceted model at the university, program, course and individual level. This model can be applied successfully to similar contexts. Thus the thesis advances both theory and practice in this under-researched and under-theorised area.
Outcome of Different Timings of Radiotherapy in Implant-Based Breast Reconstructions

Background: The therapeutic role of postmastectomy radiation therapy has been demonstrated both in locally advanced breast cancer and in other high-risk conditions. Implant-based breast reconstruction for irradiated patients can generate higher complication rates. In this study, the authors observed the effects of radiation on temporary expanders and permanent implants. The estimate of the totally failed reconstruction rate was the principal endpoint of this study. Capsular contracture rates and patients' and surgeons' subjective evaluations were the secondary endpoints. Methods: Two hundred fifty-seven patients were consecutively involved in this study. The population was stratified into two groups: group 1, postmastectomy radiation therapy on permanent implants (n = 109 patients); and group 2, postmastectomy radiation therapy on tissue expanders (n = 50 patients). A nonirradiated control group made up of 98 patients was selected randomly. All patients underwent a two-stage immediate breast reconstruction with subpectoral temporary expanders and permanent implants. Results: The totally failed reconstruction rate was significantly higher in group 2, with 40 percent of unsuccessful reconstructions compared with 6.4 percent in group 1 and 2.3 percent in the control group (p < 0.0001). The capsular contracture rate was significantly higher for groups 1 and 2 compared with the control group. The shape and symmetry assessment and the patients' opinions demonstrated a higher incidence of good results in group 1 in comparison with group 2. The best scores were always obtained by the control group. Conclusion: This study demonstrated that radiotherapy during tissue expansion may compromise the outcome of implant-based breast reconstruction. CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, II. Figure. No caption available.
Clinical Features and Pathogenesis of Macroglobulinaemia

Serum protein abnormalities may be classified into " dysproteinaemias "-quantitative alterations in normal serum components-and " paraproteinaemias," in which serum globulins normally absent or present in only minimal concentration (myeloma globulins, cryoglobu lins, and macroglobulins) are found in greatly increased amount. Macroglobulins are globulins of high mole cular weight (over one million) whose presence is associated with a definite syndrome, " macroglobulin aemia," which requires ultracentrifugal analysis of the serum for conclusive diagnosis (Waldenstrom, 1944, 1948). This paper describes three new cases of macro globulinaemia and refers briefly to one (Case 4) previously reported (Mackay, 1956). The condition cannot be regarded as rare in Australia, for these four cases came under notice in Melbourne in a period of eight months. Patients are elderly, and males exceed females. The outstanding symptoms are lethargy and a bleeding tendency (epistaxis, oral bleeding, and easy bruising). There may be a history of vague ill-health for several years, with recurrent infections, often of the respiratory tract. Examination discloses slight painless enlargement of the liver, spleen, and lymph nodes in most cases, but bulky lymphoid hyperplasia seldom occurs (Mackay, 1956; Jahnke et al., 1956). Peripheral blood examination reveals some degree of anaemia, and usually pancytopenia. Despite the pro nounced bleeding tendency, no consistent coagulation defect is observed (Jahnke et al., 1956). A skeletal survey shows, at most, osteoporosis, but no focal translucencies. Many of the laboratory findings depend on the hyper globulinaemia, which ranges from 4 to 8 g. per 100 ml. : these include rouleaux formation in blood smears, a high erythrocyte sedimentation rate, a positive formol-gel test, and a myeloma-like protein component on filter-paper electrophoresis of serum. The serum viscosity increases with a fall in temperature, often with the formation of a gel which redissolves on warming ; this gel represents one type of cryoglobulin. The Sia test (a dense white pre cipitate on adding a drop of serum to distilled water) is a useful screening test, although false positives may occur, notably in multiple myeloma.
Evolution of Solitary and Group Transport Behaviors for Autonomous Robots Capable of Self-Assembling

Group transport is performed in many natural systems and has become a canonical task for studying cooperation in robotics. We simulate a system of simple, insect-like robots that can move autonomously and grasp objects as well as each other. We use artificial evolution to produce solitary transport and group transport behaviors. We show that robots, even though not aware of each other, can be effective in group transport. Group transport can even be performed by robots that behave as in solitary transport. Still, robots engaged in group transport can benefit from behaving differently from robots engaged in solitary transport. The best group transport behaviors yielded by half of the evolutions let robots organize into self-assembled structures. This provides evidence that self-assembly can provide adaptive value to individuals that compete in an artificial evolution based on task performance. We conclude the article by discussing potential implications for evolutionary biology and robotics.
Cholesterol‐enriched membrane rafts and insulin secretion

The failure of pancreatic β‐cells to supply insulin in quantities sufficient to maintain euglycemia is a hallmark of type 2 diabetes. Perturbation of β‐cell cholesterol homeostasis, culminating in elevated intracellular cholesterol levels, impairs insulin secretion and has therefore been proposed as a mechanism contributing to β‐cell dysfunction. The manner in which this occurs, however, is unclear. Cholesterol is an essential lipid, as well as a major component of membrane rafts, and numerous proteins critical for the regulation of insulin secretion have been reported to associate with these domains. Although this suggests that alterations in membrane rafts could partially account for the reduction in insulin secretion observed when β‐cell cholesterol accumulates, this has not yet been demonstrated. In this review, we provide a brief overview of recent work implicating membrane rafts in some of the basic molecular mechanisms of insulin secretion, and discuss the insight it provides into the β‐cell dysfunction characteristic of type 2 diabetes. (J Diabetes Invest, doi: 10.1111/j.2040‐1124.2012.00200.x, 2012)
Thriving on Challenge: Examining One Teacher’s View on Sources of Support for Motivation and Well-Being

Alarmingly high rates of teacher attrition exist in contexts designed for students with considerable needs, such as in alternative education programs serving marginalized youth. Research has linked teachers’ levels of motivation and well-being to their effectiveness and retention. Consequently, we explore what distinguishes teachers who thrive in contexts others find taxing. Specifically, we investigate whether and how their motivation and well-being support their teaching effectiveness. As part of a larger case study of an alternative education program for youth who haven’t found success in mainstream schools, this article reports a semistructured interview asking whether and how one teacher’s perceived autonomy, belonging, and competence This Article (Subscription-only) is brought to you by Scholarship@Western. It has been accepted for inclusion in Exceptionality Education International by an authorized administrator of Scholarship@Western. For more information, please contact jspecht@uwo.ca. Recommended Citation Perry, N. E. , Brenner, C. , Collie, R. J., & Hofer, G. (2015) Thriving on Challenge: Examining One Teacher’s View on Sources of Support for Motivation and Well-Being. Exceptionality Education International, 25, 6-34. Retrieved from http://ir.lib. uwo.ca/eei/ vol25/iss1/2 support other facets of his motivation (e.g., teaching efficacy) and his well-being (i.e., constructive responses to potentially stressful events.) Plentiful evidence was found to link our researcher-derived constructs from self-determination theory to the teacher’s professional experiences in general, and to his work with youth in particular, indicating that our conceptual framework is an authentic representation of his experience. Implications for theory and research are discussed. ISSN 1918-5227 Pages 634 Follow this and additional works at: http://ir.lib. uwo.ca/eei Exceptionality Education International 2015, Vol. 25, No. 1, pp. 6–34 ISSN 1918-5227 6 Thriving on Challenge: Examining One Teacher’s View on Sources of Support for Motivation and Well-Being Nancy E. Perry, Charlotte A. Brenner University of British Columbia
A coalescence approach to gene conversion.

In this paper we develop a coalescent model with intralocus gene conversion. Such models are of increasing importance in the analysis of intralocus variability and linkage disequilibrium. We derive the distribution of the waiting time until a gene conversion event occurs in a sample in terms of the distribution of the length of the transferred segment, zeta. We do not assume any specific form of the distribution of zeta. Further, given that a gene conversion event occurs we find the distribution of (sigma, tau), the end points of the transferred segment and derive results on correlations between local trees in positions chi(1) and chi(2). Among other results we show that the correlation between the branch lengths of two local trees in the coalescent with gene conversion (and no recombination) decreases toward a nonzero constant when the distance between chi(1) and chi(2) increases. Finally, we show that a model including both recombination and gene conversion might account for the lack of intralocus associations found in, e.g., Drosophila melanogaster.
Reconsidering the “Asphalt Identikit”

Background/Aim The “asphalt identikit” theory suggests that driving cessation inevitably leads to feelings of incompetence and dependency. This article challenges this proposition by investigating the driving-related possible selves of British older adults living in West London. Methods Thematic analysis of data from 19 of 39 interviews in which older adults participating in a larger study talked about driving in the context of their grocery shopping. Results Three themes were evident: “I can drive – that makes a huge difference,” “Expecting to lose my license,” and “I gave up my license. ” Discussion Driving cessation is not a dreaded possible self for all older adults. Older adults may use a variety of identity maintenance processes to retain their positive sense of self. Conclusions Mental well-being can be maintained during driving cessation by finding ways to compensate for the loss of a license and finding alternative ways of achieving hoped-for possible selves.
Nudge, Nudge, Think, Think: Using Experiments to Change Civic Behaviour

How can governments persuade citizens to act in socially beneficial ways? Thaler and Sunstein's book Nudge drew on work from behavioural economics to claim that citizens might be encouraged through 'light touch interventions' (i.e.nudges) to take action. In this ground-breaking successor to Nudge, Peter John and his colleagues argue that an alternative approach also needs to be considered, based on what they call a 'think' strategy. Their core idea is that citizens should themselves deliberate and decide their own priorities as part of a process of civic and democratic renewal. The authors not only set out these divergent approaches in theory but they offer evidence from a series of experiments to show how using techniques from 'nudge' or 'think' repertoires work in practice and how that practice is made effective. The book is unique in exploring an expanding field of policy and social science interest - changing civic behaviour, using insights from another growing field of social science interest - the rise of experimental methods.
Endemic and Epidemic Acinetobacter Species in a University Hospital: an 8-Year Survey

ABSTRACT The prevalence of the currently known Acinetobacter species and related trends of antimicrobial resistance in a Dutch university hospital were studied. Between 1999 and 2006, Acinetobacter isolates from clinical samples were collected prospectively. Isolates were analyzed by amplified fragment length polymorphism fingerprinting. For species identification, a profile similarity cutoff level of 50% was used, and for strain identification, a cutoff level of 90% was used. Susceptibility for antimicrobial agents was tested by disk diffusion by following the CLSI guideline. The incidences of Acinetobacter isolates ranged from 1.7 to 3.7 per 10,000 patients per year, without a trend of increase, during the study years. Twenty different species were distinguished. Acinetobacter baumannii (27%) and Acinetobacter genomic species (gen. sp.) 3 (26%) were the most prevalent. Other species seen relatively frequently were Acinetobacter lwoffii (11%), Acinetobacter ursingii (4%), Acinetobacter johnsonii (4%), and Acinetobacter junii (3%). One large cluster of A. baumannii, involving 31 patients, and 16 smaller clusters of various species, involving in total 39 patients, with at most 5 patients in 1 cluster, occurred. Overall, 37% of the A. baumannii isolates were fully susceptible to the tested antibiotics. There was a borderline significant (P = 0.059) trend of decreasing susceptibility. A. baumannii was the Acinetobacter species causing the largest burden of multiple-antibiotic resistance and transmissions in the hospital.
Effect of ammonium salts on brain metabolism

Ammonium acetate (13 m-mol), ammonium bicarbonate (13 m-mol), and ammonium hydroxide (30 m-mol) were administered intravenously to three separate groups of five dogs. Ammonium acetate and bicarbonate were given over a period of 15 minutes, ammonium hydroxide was given for 30 minutes. In all dogs, after 15 minutes' infusion, the blood ammonia concentration was similar to that found in patients with hepatic coma. When the ammonium hydroxide had been given for 30 minutes, lightening of anaesthesia was noted in all dogs studied. At this time blood ammonia values were over 1,000 μg/100 ml in two animals. Subsequent deepening of anaesthesia was observed after termination of the infusion. In all animals studied there was an increase in cerebral glucose consumption with little change in oxygen utilization. Arterial lactic acid was studied in the group given ammonium bicarbonate and found to increase at the same time as the increase in glucose utilization. Hyperventilation was precipitated by both acid and alkalilne ammonium salts. Lactic acidosis appeared to be the cause rather than the result of the hyperventilation. The protective effect of hyperventilation on brain metabolism is discussed.
Autoradiographic localization of voltage-dependent sodium channels on the mouse neuromuscular junction using 125I-alpha scorpion toxin. I. Preferential labeling of glial cells on the presynaptic side

Alpha-scorpion toxins bind specifically to the voltage-sensitive sodium channel in excitable membranes, and binding is potential-dependent (Catterall, 1984). The radioiodinated toxin II from the scorpion Androctonus australis Hector (alpha ScTx) was used to localize voltage- sensitive sodium channels on the presynaptic side of mouse neuromuscular junctions (NMJ) by autoradiography using both light and electron microscopy. Silver grain localization was analyzed by the cross-fire method. At the light-microscopic level, grain density over NMJ appeared 6–8x higher than over nonjunctional muscle membrane. The specificity of labeling was verified by competition/displacement with an excess of native alpha ScTx. Labeling was also inhibited by incubation in depolarizing conditions, showing its potential- dependence. At the electron-microscopic level, analysis showed that voltage-sensitive sodium channels labeled with alpha ScTx were almost exclusively localized on membranes, as expected. Due to washout after incubation, appreciable numbers of binding sites were not found on the postsynaptic membranes. However, on the presynaptic side, alpha ScTx- labeled voltage-sensitive sodium channels were localized on the membrane of non-myelin-forming Schwann cells covering NMJ. The axonal presynaptic membrane was not labeled. These results show that voltage- sensitive sodium channels are present on glial cells in vivo, as already demonstrated in vitro (Chiu et al., 1984; Schrager et al., 1985). It is proposed that these glial channels could be indirectly involved in the ionic homeostasis of the axonal environment.
The Limits to Parapatric Speciation: Dobzhansky–Muller Incompatibilities in a Continent–Island Model

How much gene flow is needed to inhibit speciation by the accumulation of Dobzhansky–Muller incompatibilities (DMIs) in a structured population? Here, we derive these limits in a classical migration–selection model with two haploid or diploid loci and unidirectional gene flow from a continent to an island. We discuss the dependence of the maximum gene-flow rate on ecological factors (exogeneous selection), genetic factors (epistasis, recombination), and the evolutionary history. Extensive analytical and numerical results show the following: (1) The maximum rate of gene flow is limited by exogeneous selection. In particular, maintenance of neutral DMIs is impossible with gene flow. (2) There are two distinct mechanisms that drive DMI evolution in parapatry, selection against immigrants in a heterogeneous environment and selection against hybrids due to the incompatibility. (3) Depending on the mechanism, opposite predictions result concerning the genetic architecture that maximizes the rate of gene flow a DMI can sustain. Selection against immigrants favors evolution of tightly linked DMIs of arbitrary strength, whereas selection against hybrids promotes the evolution of strong unlinked DMIs. In diploids, the fitness of the double heterozygotes is the decisive factor to predict the pattern of DMI stability.
Effect of ammonium chloride and dietary phosphorus in the azotaemic rat. Part II--Kidney hypertrophy and calcium deposition.

BACKGROUND Kidney hypertrophy is stimulated by both partial nephrectomy and NH(4)Cl administration. Also, parathyroidectomy (PTX) has been reported to prevent kidney hypertrophy induced by a high protein diet. Our goal was to determine in the azotaemic rat: (i) the combined effects of NH(4)Cl administration and dietary phosphorus on the development of kidney hypertrophy and calcium deposition in the kidney and (ii) whether the absence of parathyroid hormone (PTH) affected the development of kidney hypertrophy and calcium deposition. METHODS High (HPD, 1.2%), normal (NPD, 0.6%) or low (LPD, <0.05%) phosphorus diets were given to 5/6 nephrectomized rats for 30 days. In each dietary group, one-half of the rats were given NH(4)Cl in the drinking water. The six groups of rats were: (i) HPD + NH(4)Cl; (ii) HPD; (iii) NPD + NH(4)Cl; (iv) NPD; (v) LPD + NH(4)Cl and (vi) LPD. In a separate study, PTX was performed to determine whether PTH affected renal hypertrophy in 5/6 nephrectomized rats given NH(4)Cl. RESULTS Both with and without NH(4)Cl (+/-NH(4)Cl), kidney weight was greatest (P<0.05) in the HPD groups. In each dietary phosphorus group, kidney weight was greater (P<0.05) in the NH(4)Cl group. In both the +/-NH(4)Cl groups, kidney calcium content was greatest (P<0.05) in the HPD group, but was less (P<0.05) in the NPD and HPD groups given NH(4)Cl. An inverse correlation was present between creatinine clearance and kidney calcium content (r = -0.51, P<0.001). When factored for kidney weight, creatinine clearance was less (P<0.05) in the HPD group in both the +/-NH(4)Cl groups, but was greater in the HPD + NH(4)Cl than in the HPD group. In PTX rats, kidney weight was greater (P<0.05) and kidney calcium deposition was less (P<0.05) in rats given NH(4)Cl. CONCLUSIONS In azotaemic rats studied for 30 days, NH(4)Cl administration induced kidney hypertrophy. A HPD also induced kidney hypertrophy. The effects on kidney calcium deposition were divergent for which NH(4)Cl administration decreased and a HPD increased calcium deposition. The inverse correlation between kidney calcium content and creatinine clearance suggests that kidney calcium deposition is harmful to renal function. When factored for kidney weight, the lower creatinine clearance in the high phosphorus group suggests that kidney hypertrophy does not completely compensate for the harmful effects of a HPD. This result also suggests that a longer study would probably result in more rapid deterioration in the high phosphorus group. In PTX rats, the absence of PTH did not prevent NH(4)Cl from inducing kidney hypertrophy and reducing kidney calcium deposition. In conclusion, NH(4)Cl and dietary phosphorus each independently affect kidney growth and calcium deposition in the growing rat with renal failure.
Measurement Invariance of the Pay Satisfaction Questionnaire Across Three Countries

In recent years, pay satisfaction has been increasingly studied in an international context, prompting the importance of examining whether the Pay Satisfaction Questionnaire (PSQ) is invariant across countries other than the United States. This study investigated the measurement invariance across three countries, namely, the United States (N = 321), Belgium (N = 301), and Cyprus (N = 132). Results showed that the measurement structure of the PSQ was invariant across these different countries because there was no departure from measurement invariance in terms of factor form, factor pattern coefficients, factor variances, and factor covariances. These results show promise for the equivalence of PSQ ratings across different countries. Future research is needed to test the equivalence further across other countries and samples.