Miracle-dz/UniFAR-FTUs huggingface dataset:
The Effects of Imputing the Missing Standard Deviations on the Standard Error of Meta Analysis Estimates

A common problem in the meta analysis of continuous data is that some studies do not report sufficient information to calculate the standard deviation (SDs) of the treatment effect. One of the approaches in handling this problem is through imputation. This article examines the empirical implications of imputing the missing SDs on the standard error (SE) of the overall meta analysis estimate. The simulation results show that if the SDs are missing under Missing Completely at Random and Missing at Random mechanism, imputation is recommended. With non random missing, imputation can lead to overestimation of the SE of the estimate.
Working Memory in Deaf Children with Cochlear Implants: Correlations between Digit Span and Measures of Spoken Language Processing

One of the most important problems in the field of pediatric cochlear implants is understanding the enormous individual differences in performance among children on a wide variety of outcome measures that assess speech perception, language comprehension. speech intelligibility, and reading. Some deaf children with cochlear implants do very well on standardized audiological and language tests and appear to be well on their way to acquiring spoken language through their implants, whereas other children do much more poorly and apparently never appear to reach these critical milestones in speech and language development.1 What is the basis for these individual differences? Recent findings suggest that one factor may be related to the perceptual processing of spoken words, that is, the encoding, storage, and retrieval of the phonological representations of spoken words, and the use of working memory and rehearsal mechanisms.1,2 To examine the role of working memory in speech perception, word recognition, speech production, language, and reading tasks, we obtained auditory digit spans from 8- and 9-year-old prelingually deaf children who had used their implants for a period of at least 4 years, then computed correlations between digit span and 4 sets of outcome measures.
Nutrient-rich foods in relation to various measures of anthropometry.

BACKGROUND Nutrient quality systems, for example the nutrient-rich foods (NRF) index, measure the nutrient quality of individual foods and may be used to assess the nutrient density of the overall diet. It is not yet known whether the NRF index is helpful in weight management. We hypothesize that a nutrient-dense diet is associated with a lower body weight and waist circumference. OBJECTIVE The objective of the present study was to examine the association between the NRF index and various measures of anthropometry. METHODS This study was carried out in a sample of 2044 men and 2925 women, aged ≥55 years, participating in a community-based prospective cohort study in Rotterdam, The Netherlands. The NRF9.3 algorithms were used to estimate the nutrient density of the subjects' diets. Linear regression was used to examine the association between the NRF index scores and body mass index (BMI), body weight, waist circumference, wait-to-hip ratio and waist-to-height ratio. RESULTS Subjects with a high NRF9.3 index score had a lower energy intake (EI) as compared to those with low NRF9.3 index score. However, after adjustment for age, gender and other confounders, the NRF9.3 index score as well as the Nutrient Rich 9 index score were positively associated with BMI, body weight, waist circumference and waist-to-height ratio. CONCLUSIONS Although subjects with a high NRF9.3 index score had a lower EI than those subjects with a low index score, their BMI, body weight, waist circumference and waist-to-height ratio was higher. The association between nutrient quality and body composition is therefore complex.
The near‐global mesospheric potassium layer: Observations and modeling

The meteoric metal layers act as unique tracers of chemistry and dynamics in the upper atmosphere. Existing lidar studies from a few locations show that K exhibits a semiannual seasonality (winter and summer maxima), quite unlike the annual seasonality (winter maximum and summer minimum) seen with Na and Fe. This work uses spaceborne observations made with the Optical Spectrograph and InfraRed Imager System instrument on the Odin satellite to retrieve the near‐global K layer for the first time. The satellite data (2004 to mid‐2013) are used to validate the implementation of a recently proposed potassium chemistry scheme in a whole atmosphere chemistry climate model, which provides a chemical basis for this semiannual seasonal behavior. The satellite and model data show that this semiannual seasonality is near global in extent, with the strongest variation at middle and high latitudes. The column abundance, centroid layer height, and root‐mean‐square width of the K layer are consistent with the limited available lidar record. The K data set is then used to investigate the impact of polar mesospheric clouds on the metal layers at high latitudes during summer. Finally, the occurrence frequency of sporadic K layers and their possible link to sporadic E layers are examined.
Interaction of oxidative stress, astrocyte swelling and cerebral ammonia toxicity

Purpose of reviewDescription of the role of oxidative stress in the pathogenesis of cerebral ammonia toxicity and hepatic encephalopathy. Recent findingsAmmonia plays a key role in the pathogenesis of hepatic encephalopathy, which manifests as a neuropsychiatric syndrome accompanying acute and chronic liver failure. One consequence of ammonia action on the brain is astrocyte swelling, which triggers the generation of oxidative/nitrosative stress at the level of NADPH oxidase, nitric oxide synthases and the mitochondria. A self-amplifying signaling loop between oxidative stress and astrocyte swelling has been proposed. Consequences of the ammonia-induced oxidative/nitrosative stress response are protein modifications through nitration of tyrosine residues and oxidation of astrocytic and neuronal RNA. Nitrosative stress also mobilizes zinc from intracellular stores with impact on gene expression. These alterations may at least in part mediate cerebral ammonia toxicity through disturbances of intracellular and intercellular signaling and of synaptic plasticity. SummaryOxidative/nitrosative stress and a low-grade cerebral edema as key events in the pathogenesis of ammonia toxicity and hepatic encephalopathy may offer potential new strategies for treatment. Ammonia-induced oxidation of RNA and proteins may impair postsynaptic protein synthesis, which is critically involved in learning and memory consolidation. RNA oxidation offers a novel explanation for multiple disturbances of neurotransmitter systems and gene expression and the cognitive deficits observed in hepatic encephalopathy.
Enhanced tunneling electroresistance effect in composite ferroelectric tunnel junctions with asymmetric electrodes

Theoretical investigations on ferroelectric tunnel junctions (FTJs) with asymmetric electrodes and a composite barrier are presented. A large tunneling electroresistance effect exists for the Pt/SrTi0_3/BaTi0_3/SrRu0_3 junction; on the other hand, exchange of the dielectric and ferroelectric layer stacking sequence can seriously degrade the performance. These correlations are rationalized by the proposed concept of an asymmetry factor, defined as the ratio between the average barrier heights of FTJs for two opposite polarization orientations. We show that a large asymmetry factor is beneficial to FTJs. This work may provide a way to enhance the performance of FTJs by structure engineering.
Source of dietary fibre and diverticular disease incidence: a prospective study of UK women

Background Previous prospective studies have found the incidence of intestinal diverticular disease decreased with increasing intakes of dietary fibre, but associations by the fibre source are less well characterised. We assessed these associations in a large UK prospective study of middle-aged women. Methods and findings During 6 (SD 1) years follow-up of 690 075 women without known diverticular disease who had not changed their diet in the last 5 years, 17 325 were admitted to hospital or died with diverticular disease. Dietary fibre intake was assessed using a validated 40-item food questionnaire and remeasured 1 year later in 4265 randomly-selected women. Mean total dietary fibre intake at baseline was 13.8 (SD 5.0) g/day, of which 42% came from cereals, 22% from fruits, 19% from vegetables (not potatoes) and 15% from potatoes. The relative risk (95% CI) for diverticular disease per 5 g/day fibre intake was 0.86 (0.84 to 0.88). There was significant heterogeneity by the four main sources of fibre (p<0.0001), with relative risks, adjusted for each of the other sources of dietary fibre of 0.84 (0.81 to 0.88) per 5 g/day for cereal, 0.81 (0.77 to 0.86) per 5 g/day for fruit, 1.03 (0.93 to 1.14) per 5 g/day for vegetable and 1.04 (1.02 to 1.07) per 1 g/day for potato fibre. Conclusions A higher intake of dietary fibre is associated with a reduced risk of diverticular disease. The associations with diverticular disease appear to vary by fibre source, and the reasons for this variation are unclear.
Wrapper Chain Design for Testing TSVs Minimization in Circuit-Partitioned 3D SoC

Three dimensional (3D) System-on-Chips (SoCs) that typically employ through-silicon vias (TSVs) as vertical interconnects, emerge as a promising solution to continue Moore's law. Whereas, it also brings challenging problems, one of which is the test wrapper chain design and optimization, especially for circuit-partitioned 3D SoCs in which scan chains can cross among layers. Test time is the primary goal for wrapper chain design, both for 2D and 3D SoCs. The 3D SoC wrapper chain design problem can be converted into the well-studied2D one by projecting wrapper chain components of all layers to one virtual layer. Thereafter, we can leverage 2D optimization algorithms to determine the composition of wrapper chains and thus guarantee minimal testing time for 3D SoCs. One specific thing for circuit-partitioned 3D SoCs is that TSVs are needed to connect cross-layer wrapper structures to form the wrapper chains. As TSVs occupy planar chip area and will aggravate the routing congestion problem, it is necessary to reduce TSVs for test purpose as much as possible. In this work, we observe that by varying the connection orders of wrapper chain components, e.g., scan chains and I/O cells, the TSVs consumed vary significantly. Based on the above, we formulate this problem and propose novel heuristic to tackle it. Experimental results show that the proposed solution can save on average 33.2% amount of TSVs when compared to a prior intuitive method.
Discordant Phylogenies within the rrn Loci of Rhizobia

ABSTRACT It is evident from complete genome sequencing results that lateral gene transfer and recombination are essential components in the evolutionary process of bacterial genomes. Since this has important implications for bacterial systematics, the primary objective of this study was to compare estimated evolutionary relationships among a representative set of α-Proteobacteria by sequencing analysis of three loci within their rrn operons. Tree topologies generated with 16S rRNA gene sequences were significantly different from corresponding trees assembled with 23S rRNA gene and internally transcribed space region sequences. Besides the incongruence in tree topologies, evidence that distinct segments along the 16S rRNA gene sequences of bacteria currently classified within the genera Bradyrhizobium, Mesorhizobium and Sinorhizobium have a reticulate evolutionary history was also obtained. Our data have important implications for bacterial taxonomy, because currently most taxonomic decisions are based on comparative 16S rRNA gene sequence analysis. Since phylogenetic placement based on 16S rRNA gene sequence divergence perhaps is questionable, we suggest that the proposals of bacterial nomenclature or changes in their taxonomy that have been made may not necessarily be warranted. Accordingly, a more conservative approach should be taken in the future, in which taxonomic decisions are based on the analysis of a wider variety of loci and comparative analytical methods are used to estimate phylogenetic relationships among the genomes under consideration.
Information Spread Over an Internet-mediated Social Network: Phases, Speed, Width, and Effects of Promotion

In this study, we looked at the effect of promotion in the speed and width of spread of information on the Internet by tracking the diffusion of news articles over a social network. Speed of spread means the number of readers that the news has reached in a given time, while width of spread means how far the story has travelled from the news originator within the social network. After analyzing six stories in a 30-hour time span, we found out that the lifetime of a story's popularity among the members of the social network has three phases: Expansion, Front-page, and Saturation. Expansion phase starts when a story is published and the article spreads from a source node to nodes within a connected component of the social network. Front-page phase happens when a news aggregator promotes the story in its front page resulting to the story's faster rate of spread among the connected nodes while at the same time spreading the article to nodes outside the original connected component of the social network. Saturation phase is when the story ages and its rate of spread within the social network slows down, suggesting popularity saturation among the nodes. Within these three phases, we observed minimal changes on the width of information spread as suggested by relatively low increase of the width of the spread's diameter within the social network. We see that this paper provides the various stakeholders a first-hand empirical data for modeling, designing, and improving the current web-based services, specifically the IT educators for designing and improving academic curricula, and for improving the current web-enabled deployment of knowledge and online evaluation of skills.
Intrahepatic cholangiocarcinoma

all patients with ICC present with advanced, incurable disease (Shaib et al., 2007). Even ICC patients who have undergone complete surgical resection, the recurrence rate remains quite high and the 5-year survival rate is unfavorable (Kawarada et al., 2002; Anderson et al., 2004). Therefore, ICC is a slow growing but highly metastatic cancer, which is the major cause of death in ICC patients. A global increase in ICC related mortality and incidence of ICC have been reported (Khan et al., 2002; Patel, 2002). The prognosis for patients with ICC
Lucifer Yellow uptake by CHO cells exposed to magnetic and electric pulses

Lucifer Yellow uptake by CHO cells exposed to magnetic and electric pulses Background. The cell membrane acts as a barrier that hinders free entrance of most hydrophilic molecules into the cell. Due to numerous applications in medicine, biology and biotechnology, the introduction of impermeant molecules into biological cells has drawn considerable attention in the past years. One of the most famous methods in this field is electroporation, in which electric pulses with high intensity and short duration are applied to the cells. The aim of our study was to investigate the effect of time-varying magnetic field with different parameters on transmembrane molecular transport. Materials and methods. ‘Moreover, a comparison was made between the uptake results due to magnetic pulse exposure and electroporation mediated uptake. ’ at the end of Background part. The Chinese hamster ovary (CHO) cells were exposed to magnetic pulses of 2.2 T peak strength and 250 μs duration delivered by Magstim stimulator and double 70 mm coil. Three different frequencies of 0.25, 1 and 10 Hz pulses with 112, 56 and 28 number of pulses were applied (altogether nine experimental groups) and Lucifer Yellow uptake was measured in each group. Moreover, maximum uptake of Lucifer Yellow obtained by magnetic pulses was compared to the measured uptake due to electroporation with typical parameters of 8 pulses of 100 μs, repetition frequency of 1 Hz and electric field intensities of 200 to 600 V/cm. Results and conclusions. Our results show that time-varying magnetic field exposure increases transmembrane molecular transport and this uptake is greater for lower frequencies and larger number of pulses. Besides, the comparison shows that electroporation is more effective than pulsed magnetic field, but the observed uptake enhancement due to magnetic exposure is still considerable.
Leptospirosis in Vellore: A Clinical and Serological Study

Leptospirosis is a severe spirochetal zoonosis in the world. It is considered an occupational disease of persons engaged in agriculture, sewage works, forestry, and animal slaughtering. A study was conducted with an objective of assessing the seroprevalence of leptospirosis in and around Vellore district, Tamil Nadu. The study was based on the signs and symptoms of the patients reporting fever in Vellore Municipal Clinic (Urban Malarial Scheme). Blood samples were collected from 129 patients. Animal studies were conducted from 24 rodents captured form the market place of the Vellore municipality. In the ZET (Zonal Entomological Team, Vellore) Laboratory the sera were examined by macroscopic slide agglutination test (MSAT). In the MAST, totally 10 positive leptospiral cases from human beings and 10 positive leptospiral cases from rats (Rattus rattus and Rattus norvegicus) were found out. Then both positive cases of leptospiral vials were labeled, sealed, and sent to the Leptospirosis Research Laboratory, Madhavaram, Chennai, for further serovars examination. Among the various serovars identified autumnalis was more prevalent. Our findings showed that the age groups between 15 and 55 years showed more susceptibility. Particularly the adults were more infected. The majority of seropositive individuals in the cases had only subclinical infection. Rodents were abundant and contributed to enzootic and endemic prevalence of leptospirosis.
Effect of surface pretreatment with natural essential oils on the weathering performance of spruce wood

The efficiency of surface pretreatment with natural essential oils relative to the weathering performance of Norway spruce wood was examined. This study investigated the combination of this pretreatment increasing biological resistance and oil-based coating with protection against ultraviolet light and hydrophobic topcoat with silicon nanoparticles during natural and artificial weathering. The coating systems were exposed to 24 months of natural weathering in climatic conditions of Central Europe and 2,016 hours of artificial weathering. The synergistic effect of a coating system based on safflower with essential oils and commercial oil-based coating was the most efficient. The application of one layer of an oil-based coating in a wet state of surface pretreatment exhibited results comparable to the application of two layers in a dry state. For all coating systems, increasing changes of colour, roughness, and surface wettability were observed, which differed according to the weathering method. Weathering performance of transparent coating systems was evaluated during both weathering tests by exact measurements, laser scanning microscopy and visual evaluation as well. Total colour difference did not prove to be a sufficient evaluation criterion to indicate coating performance during weathering.
Jejunoileal Atresia: Factors Affecting the Outcome and Long-term Sequelae

Context: Jejunoileal atresia (JIA) is a common abnormality. The outcome is conditioned by several variables. Nutritional problems, and long-term sequelae are described among those who survive. Aim: To correlate the type of JIA and its management to the outcome and long-term quality of life. Settings and Design: Forty-three cases over a 17-year period (1992–2009). Perinatal data, management, and outcome were extracted from the clinical notes. The cases that had survived were contacted to get information about their present condition. Materials and Methods: Morbidity and mortality were matched to maturity, birth weight, mode of diagnosis, type of JIA, associated anomalies, and management and duration of parenteral nutrition. Growth and quality of life in 34 cases were evaluated via a telephone interview at a minimum of one year from surgery. Statistical analysis: Fisher test, Linear regression test, Kruskal-Wallis test, Dunn's comparison test. Results: Male/Female ratio was 25/18 and median birth weight was 2.644 g. Prenatal diagnosis was recorded in 34%. Six patients (14%) had associated anomalies. Primary surgery was resection and anastomosis in 88% and temporary stoma in 12%. Length of the resected bowel ranged from 3 to 65 cm. Whenever multiple atresia was found, the bowel length was saved by multiple anastomosis. Three dehiscences and three adhesive obstructions required a reoperation. Two patients (4%) died due to a central catheter–related sepsis. Prenatal diagnosis did not influence the outcome and was associated with a higher rate of Cesarean deliveries. Interview, at a median of nine years, showed normal growth in 85%. One case of short bowel syndrome is still on parenteral support at 22 months. Conclusions: Preserving bowel length and reducing the recourse to stoma is the key to good outcome and growth. Sequelae are correlated with the type of atresia and length of residual bowel; however, they decrease their severity with time.
Performance tests and modeling on high damping magnetorheological elastomers based on bromobutyl rubber

A new kind of magnetorheological elastomer with the matrix of the bromobutyl rubber is developed. The magnetoviscoelasticity properties of the magnetorheological elastomer specimens are investigated with respect to different magnetic fields, displacement amplitudes, and frequencies under sinusoidal loadings. The experimental results show that the shear storage modulus and the loss factor of magnetorheological elastomers increase with the increasing magnetic field, excitation frequency, and the weight fraction of particles, but decrease with the increasing strain amplitude, and the magnetorheological elastomers have a high loss factor which can reach to 0.682. Then, a microphysical model based on the assumption of the chi-square distribution of the distance between adjacent ferromagnetic particles is proposed, which can eliminate the error generated by the assumption of the uniform distribution and describe the magnetorheological effect more exactly. Based on the proposed microphysical model, the magnetoviscoelasticity parameter model is modified to describe the dynamic properties of magnetorheological elastomers. It can be concluded from comparison between the numerical and experimental results that the modified magnetoviscoelasticity parameter model can describe the magnetorheological elastomer’s performance well.