Miracle-dz/UniFAR-FTUs huggingface dataset:
The Impact of Migration on Social Capital: Do Migrants Take Their Bowling Balls with Them?

Questions surrounding the impact of population migration on social capital is the focus of this study. Putnam observed that “for people as for plants, frequent repotting disrupts root systems. It takes time for a mobile individual to put down new roots. ” However, because of a trending decrease in mobility over time, Putnam rules out migration as an explanation for the long-term decline in social capital that was the subject of his widely read 1995 book Bowling Alone: America's Declining Social Capital. This study undertakes an empirical examination of the impact of migration on county-level social capital, which in tribute to Putnam one might view as an attempt to answer the question—do migrants take their bowling balls with them when they move? The potential for county-level migration of population to impact social capital levels at particular locations in space arises from the conventional argument that social capital promotes trust and cooperation among agents. This trust increases socially efficient collective action but requires investment in relationships and commitment of scarce resources to build social capital. It seems plausible that migration of population might have a negative impact on the stock of social capital by interfering with trust and cooperation among agents. However, it is also possible that migrants may take their social capital with them to new places of residence. In other words, the propensity to join social and civic organizations might reflect inherent traits of individuals who are willing to make commitments of their resources to building social capital in any community where they reside.
Supervised machine learning reveals introgressed loci in the genomes of Drosophila simulans and D. sechellia

Hybridization and gene flow between species appears to be common. Even though it is clear that hybridization is widespread across all surveyed taxonomic groups, the magnitude and consequences of introgression are still largely unknown. Thus it is crucial to develop the statistical machinery required to uncover which genomic regions have recently acquired haplotypes via introgression from a sister population. We developed a novel machine learning framework, called FILET (Finding Introgressed Loci via Extra-Trees) capable of revealing genomic introgression with far greater power than competing methods. FILET works by combining information from a number of population genetic summary statistics, including several new statistics that we introduce, that capture patterns of variation across two populations. We show that FILET is able to identify loci that have experienced gene flow between related species with high accuracy, and in most situations can correctly infer which population was the donor and which was the recipient. Here we describe a data set of outbred diploid Drosophila sechellia genomes, and combine them with data from D. simulans to examine recent introgression between these species using FILET. Although we find that these populations may have split more recently than previously appreciated, FILET confirms that there has indeed been appreciable recent introgression (some of which might have been adaptive) between these species, and reveals that this gene flow is primarily in the direction of D. simulans to D. sechellia. AUTHOR SUMMARY Understanding the extent to which species or diverged populations hybridize in nature is crucially important if we are to understand the speciation process. Accordingly numerous research groups have developed methodology for finding the genetic evidence of such introgression. In this report we develop a supervised machine learning approach for uncovering loci which have introgressed across species boundaries. We show that our method, FILET, has greater accuracy and power than competing methods in discovering introgression, and in addition can detect the directionality associated with the gene flow between species. Using whole genome sequences from Drosophila simulans and Drosophila sechellia we show that FILET discovers quite extensive introgression between these species that has occurred mostly from D. simulans to D. sechellia. Our work highlights the complex process of speciation even within a well-studied system and points to the growing importance of supervised machine learning in population genetics.
Switch costs in inhibitory control and voluntary behaviour: A computational study of the antisaccade task

An integral aspect of human cognition is the ability to inhibit stimulus‐driven, habitual responses, in favour of complex, voluntary actions. In addition, humans can also alternate between different tasks. This comes at the cost of degraded performance when compared to repeating the same task, a phenomenon called the “task‐switch cost. ” While task switching and inhibitory control have been studied extensively, the interaction between them has received relatively little attention. Here, we used the SERIA model, a computational model of antisaccade behaviour, to draw a bridge between them. We investigated task switching in two versions of the mixed antisaccade task, in which participants are cued to saccade either in the same or in the opposite direction to a peripheral stimulus. SERIA revealed that stopping a habitual action leads to increased inhibitory control that persists onto the next trial, independently of the upcoming trial type. Moreover, switching between tasks induces slower and less accurate voluntary responses compared to repeat trials. However, this only occurs when participants lack the time to prepare the correct response. Altogether, SERIA demonstrates that there is a reconfiguration cost associated with switching between voluntary actions. In addition, the enhanced inhibition that follows antisaccade but not prosaccade trials explains asymmetric switch costs. In conclusion, SERIA offers a novel model of task switching that unifies previous theoretical accounts by distinguishing between inhibitory control and voluntary action generation and could help explain similar phenomena in paradigms beyond the antisaccade task.
The Role of Databases in Improving the Quality of Care for Congenital Heart Disease

In this issue of the World Journal for Pediatric and Congenital Heart Surgery, Calderon-Colmenero and colleagues describe the efforts of the Mexican Association of Specialists in Congenital Heart Disease to improve the quality of care for children with congenital heart disease in Mexico.1 Their approach consisted of creating a national survey to assess existing resources, using this information to improve access to care while continuing to support highly specialized care for the most complex cases at regional centers, and creating a database to allow capture of uniform procedural and outcomes data.
Myocardial ischemia: a comparison between isoflurane and enflurane in coronary artery bypass patients.

Isoflurane may precipitate ischemia in patients with coronary artery disease, presumably via "coronary steal. " We sought to examine whether myocardial ischemia is more common in patients with coronary artery disease receiving isoflurane (0.7%) than in a control group receiving enflurane (0.9%). Thirty-eight patients scheduled for coronary artery bypass surgery were randomly assigned one anesthetic and monitored for ischemia. All patients had ejection fractions of at least 45%. Extraneous causes of ischemia were controlled as much as possible: arterial blood pressure was maintained within 20% of baseline (primarily with phenylephrine), heart rate was maintained below 80 bpm, effects from endotracheal intubation were monitored, and measurements were made before incision. Electrocardiogram, transthoracic echocardiography, and coronary sinus lactate measurement were used to detect ischemia. Measurements were made after insertion of vascular catheters, after intubation, and after 20 min of breathing the inhaled anesthetic. During the awake period and after induction of anesthesia with fentanyl (25 micrograms/kg), there was no significant difference detected between the two groups in incidence of ischemia: 20% in the enflurane group and 22% in the isoflurane group (P = 0.38). After 20 min of receiving the inhaled anesthetic, the incidence of ischemia in the isoflurane group increased to 50%, whereas the incidence in the enflurane group was unchanged at 20% (P = 0.02). These results show that, even with strict control of hemodynamics, isoflurane is associated with more myocardial ischemia than is enflurane.
Upper gastrointestinal symptoms and associated endoscopic and histological features in patients receiving immune checkpoint inhibitors

Abstract Background: Immune checkpoint inhibitors (ICIs) have demonstrated effectiveness in treating many malignancies. Gastrointestinal (GI) adverse events are commonly reported; however, few reports describe upper GI tract toxic effects. We aimed to describe clinical features of upper GI injury related to ICI. Methods: We studied consecutive patients who received ICIs between April 2011 and March 2018 and developed upper GI symptoms requiring esophagogastroduodenoscopy (EGD). Results: Sixty patients developed upper GI symptoms between ICI initiation and 6 months after the last infusion. Among patients who had both EGD and colonoscopy (n = 38), 21 had endoscopic evidence of inflammation involving both the upper and lower GI tract. Overall, histological signs of inflammation of the stomach were evident in 83% of patients, but inflammation of the duodenum in 38%. Total of 42 patients had other risk factors of gastritis, i.e., chemotherapy, radiotherapy, and non-steroidal anti-inflammatory drugs. Only isolated gastric inflammation was seen on endoscopy in patients without these risk factors. The rates of ulceration were similar in the cohorts with and without other risk factors for gastritis. Isolated upper GI inflammation was related to anti-PD-1/L1 in 47% of patients. Immunosuppressive therapy in our cohort with upper GI toxicity consisted of steroids (42%) and infliximab or vedolizumab (23%). Most isolated upper GI symptoms were treated with proton pump inhibitors (65%) or H2 blockers (35%). Conclusion: We observed a correlation between ICI use and onset of upper GI inflammation even when other risk factors were excluded. Gastric involvement was evident more often than duodenal involvement on endoscopic and histological level.
Guidelines for the use of hydroxycarbamide in children and adults with sickle cell disease

Department of Paediatric Haematology and Oncology, Oxford Children’s Hospital, Oxford University Hospital NHS Trust, Oxford, Department of Paediatric Haematology and Oncology, Royal London Hospitals, Barts Health NHS Trust, London, Department of Haematology, Sandwell and West Birmingham NHS Trust, West Bromwich, Department of Paediatric Haematology, Alderhey Children’s Hospital NHS Trust, Liverpool, Department of Clinical Psychology, Imperial College Healthcare NHS Trust, London, Department of Haematology, Milton Keynes Hospital NHS Trust, Milton Keynes, and Department of Haematology, Guys and St Thomas’s NHS Foundation Trust, London, UK
Consulting the oracle? Applications of modified Delphi technique to qualitative research in the hospitality industry

Purpose – The Delphi technique is used to achieve consensus among experts and/or gain judgment on complex matters. This paper aims to discuss the classical Delphi and its advantages and disadvantages in qualitative research, particularly in hospitality.Design/methodology/approach – The classical Delphi is characterized by the involvement of experts and its iterative nature. In an industry with high turnover and limited pools of specialist expertise this can lead to problems of attrition and management of the process. The paper presents two qualitative hospitality research case studies in which the classical Delphi is successfully modified to overcome its limitations.Findings – Identifying potential problems early in the research process enables critical design decisions to be made. Case one used a parallel expert group with similar experience to develop a research instrument for a limited number of prestigious experts well‐acquainted with one another who might have reached specious consensus through chann.
Murine embryos exposed to human endometrial MSCs-derived extracellular vesicles exhibit higher VEGF/PDGF AA release, increased blastomere count and hatching rates

Endometrial Mesenchymal Stromal Cells (endMSCs) are multipotent cells with immunomodulatory and pro-regenerative activity which is mainly mediated by a paracrine effect. The exosomes released by MSCs have become a promising therapeutic tool for the treatment of immune-mediated diseases. More specifically, extracellular vesicles derived from endMSCs (EV-endMSCs) have demonstrated a cardioprotective effect through the release of anti-apoptotic and pro-angiogenic factors. Here we hypothesize that EV-endMSCs may be used as a co-adjuvant to improve in vitro fertilization outcomes and embryo quality. Firstly, endMSCs and EV-endMSCs were isolated and phenotypically characterized for in vitro assays. Then, in vitro studies were performed on murine embryos co-cultured with EV-endMSCs at different concentrations. Our results firstly demonstrated a significant increase on the total blastomere count of expanded murine blastocysts. Moreover, EV-endMSCs triggered the release of pro-angiogenic molecules from embryos demonstrating an EV-endMSCs concentration-dependent increase of VEGF and PDGF-AA. The release of VEGF and PDGF-AA by the embryos may indicate that the beneficial effect of EV-endMSCs could be mediating not only an increase in the blastocyst’s total cell number, but also may promote endometrial angiogenesis, vascularization, differentiation and tissue remodeling. In summary, these results could be relevant for assisted reproduction being the first report describing the beneficial effect of human EV-endMSCs on embryo development.
Fasting glycemia in sleep disordered breathing: lowering the threshold on oxyhemoglobin desaturation.

STUDY OBJECTIVES Commonly used definitions of sleep-disordered breathing (SDB) are based on identifying discrete events of breathing abnormalities during sleep that are accompanied by an oxyhemoglobin desaturation (delta SaO2) of at least 4%. However, it is not known whether disordered breathing events with oxyhemoglobin desaturation less than 4% are associated with clinical sequelae such as abnormalities in fasting glycemia. DESIGN Cross-sectional study. SUBJECTS AND SETTING Participants from the Sleep Heart Health Study (SHHS) with a fasting glucose measurement made within a year of the baseline polysomnogram. MEASUREMENTS AND RESULTS SDB severity was defined using the apnea-hypopnea index (AHI) and the hypopnea index (HI) by counting events with different levels of oxyhemoglobin desaturation (0.0%-1.9%, 2.0%-2.9%, 3.0%-3.9%, > or = 4.0%). Fasting glucose levels were used to classify individuals into normal (<100 mg/dL), impaired (100-125 mg/dL), and diabetic (> or = 126 mg/dL) groups. Ordinal logistic regression was used to determine the adjusted relative odds of an abnormal glucose value across quartiles of the hypopnea index, independent of factors such as age, body mass index, waist circumference, and usual sleep duration. The prevalence of impaired and diabetic fasting glucose in the analytical sample was 32.9% and 5.8%, respectively. The covariate-adjusted relative odds of impaired or diabetic fasting glucose in the highest versus the lowest AHI quartile was 1.35 (95% CI: 1.04-1.76) for events with a delta SaO2 > or = 4.0%, 1.72 (95% CI: 1.20-2.48) for events with a delta SaO2 between 3.0%-3.9%, 1.41 (95% CI: 1.07-1.86) for events with a delta SaO2 between 2.0%-2.9%, and 1.07 (95% CI: 0.84-1.37) for events with a delta SaO2 between 0.0%-1.9%. The corresponding odds ratios for the HI were 1.47 (95% CI: 1.13-1.92), 2.25 (95% CI: 1.59-3.19), 1.44 (95% CI: 1.09-1.90), and 1.15 (95% CI: 0.90-1.47), respectively. CONCLUSIONS The results of this study indicate that SDB events accompanied by oxyhemoglobin desaturation of between 2% to 4% are associated with fasting hyperglycemia. These findings suggest that milder degrees of SDB may predispose to adverse metabolic outcomes.
When to Haggle

A seller faces a buyer with unknown reservation value. We show that buyer risk aversion can make it in the seller's interest to haggle. That is, the seller should make an initial offer and then, if it is rejected, make a second offer with some probability strictly less than one. This is true regardless of whether the seller haggles over price, quality, or price and quality simultaneously. The results are extended to contexts with multiple types of buyers and multiple dimensions for haggling.
A deep optical/near-infrared catalogue of Serpens

We present a deep optical/near-infrared imaging survey of the Serpens molecular cloud. This survey constitutes the complementary optical data to the Spitzer “Core To Disk” (c2d) Legacy survey in this cloud. The survey was conducted using the wide field camera at the Isaac Newton Telescope. About 0.96 square degrees were imaged in the R and Z filters, covering the entire region where most of the young stellar objects identified by the c2d survey are located. The 26 524 point-like sources were detected in both R and Z bands down to R ≈ 24.5 mag and Z ≈ 23 mag with a signal-to-noise ratio better than 3. The 95% completeness limit of our catalogue corresponds to 0.04 M_⊙ for members of the Serpens star-forming region (age 2 Myr and distance 260 pc) in the absence of extinction. Adopting the typical extinction of the observed area (A_V ≈ 7 mag), we estimate a 95% completeness level down to M ≈ 0.1 M_⊙. The astrometric accuracy of our catalogue is 0.4 arcsec with respect to the 2MASS catalogue. Our final catalogue contains J2000 celestial coordinates, magnitudes in the R and Z bands calibrated to the SDSS photometric system and, where possible, JHK_S magnitudes from 2MASS for sources in 0.96 square degrees in the direction of Serpens. This data product has already been used within the frame of the c2d Spitzer Legacy Project analysis in Serpens to study the star/disk formation and evolution in this cloud. Here we use it to obtain new indications of the disk-less population in Serpens.
Long-term Outcomes of Autologous Chondrocyte Implantation in Adolescent Patients

Background: Treating symptomatic articular cartilage lesions is challenging, especially in adolescent patients, because of longer life expectancies and higher levels of functional activity. For this population, long-term outcomes after autologous chondrocyte implantation (ACI) remain to be determined. Purpose: To evaluate long-term outcomes in adolescents after ACI using survival analyses, validated outcome questionnaires, and standard radiographs. Study Design: Case series; Level of evidence, 4. Methods: We performed a review of prospectively collected data from patients who underwent ACI between 1996 and 2013. We evaluated 27 patients aged <18 years old (29 knees; mean age, 15.9 years) who were treated by a single surgeon for symptomatic, full-thickness articular cartilage lesions over a mean 9.6-year follow-up (median, 13 years; range, 2-19 years). A mean of 1.5 lesions per knee were treated over a mean total surface area of 6.2 cm2 (range, 2.0-23.4 cm2) per knee. Survival analysis was performed using the Kaplan-Meier method, with graft failure as the end point. The modified Cincinnati Knee Rating Scale, Western Ontario and McMaster Universities Osteoarthritis Index, visual analog scale, and Short Form 36 scores were used to evaluate clinical outcomes. Patients also self-reported knee function and satisfaction. Standard radiographs were evaluated using Kellgren-Lawrence grades. Results: Both 5- and 10-year survival rates were 89%. All clinical scores improved significantly postoperatively. A total of 96% of patients rated knee function as better after surgery, and all patients indicated that they would undergo the same surgery again. Approximately 90% rated knee-specific outcomes as good or excellent and were satisfied with the procedure. At last follow-up, 12 of 26 successful knees were radiographically assessed (mean, 5.6 years postoperatively), with no significant osteoarthritis progression. Three knees were considered failures, which were managed by autologous bone grafting or osteochondral autologous transplantation. Twenty knees required subsequent surgical procedures. These were primarily associated with periosteum and were arthroscopically performed. Conclusion: ACI resulted in satisfactory survival rates and significant improvements in function, pain, and mental health for adolescent patients over a long-term follow-up. ACI was associated with very high satisfaction postoperatively, despite the subsequent procedure rate being relatively high primarily because of the use of periosteum. If periosteum is used, this rate should be a consideration when discussing ACI with patients and their parents.
Caching With Partial Adaptive Matching

We study the caching problem when we are allowed to match each user to one of a subset of caches after its request is revealed. We focus on non-uniformly popular content, specifically when the file popularities obey a Zipf distribution. We study two extremal schemes: one focusing on coded server transmissions while ignoring matching capabilities and the other focusing on adaptive matching while ignoring potential coding opportunities. We derive the rates achieved by these schemes and characterize the regimes in which one outperforms the other. We also compare them to information-theoretic outer bounds and finally propose a hybrid scheme that generalizes ideas from the two schemes and performs at least as well as either of them in most memory regimes.