Miracle-dz/UniFAR-FTUs huggingface dataset:
Low-dose multidetector CT angiography in the evaluation of infrarenal aorta and peripheral arterial occlusive disease.

PURPOSE To investigate the ionizing radiation dose, image quality, and diagnostic performance of computed tomographic (CT) angiography of the peripheral arteries with three different CT angiographic acquisition protocols, with use of pretreatment digital subtraction angiography (DSA) as the reference standard. MATERIALS AND METHODS The study was approved by the institutional review board and performed in agreement with the 1990 Declaration of Helsinki and subsequent amendments. Each patient provided informed consent before undergoing CT. The authors performed a prospective, single-center, randomized comparison of three different x-ray exposure CT acquisition protocols in 60 randomized patients with peripheral arterial occlusive disease referred for 64-section multidetector CT angiography of the lower limb (0.625-mm collimation, intravenous administration of 100 mL of iomeprol [400 mg iodine per milliliter] at 4 mL/sec). The acquisition protocols were performed with (a) 120 kVp and a noise index of 26 (moderate noise reduction [MNR]), referred to as the 120-kVp MNR group; (b) 80 kVp and a noise index of 26, referred to as the 80-kVp MNR group; and (c) 80 kVp and a noise index of 30 (high noise reduction [HNR]), referred to as the 80-kVp HNR group. Axial and three-dimensional (3D) images were qualitatively and quantitatively compared by using the overall F test and pairwise comparisons. The X(2) test was used to compare the three protocols in terms of diagnostic performance in patients who also underwent DSA before an interventional procedure. RESULTS Significantly higher attenuation values were obtained in the vessels with the 80-kVp MNR and 80-kVp HNR acquisition protocols. No significant differences were noted in terms of image quality with either axial source images or 3D reconstructions. Likewise, no significant differences were found among the three protocols in terms of noise throughout the peripheral vasculature. Finally, no significant differences were found among the three groups with regard to diagnostic performance. Overall dose reductions of 48% and 61% were obtained for the 80-kVp MNR and 80-kVp HNR protocols, respectively. CONCLUSION Substantial reductions of radiation dose are achievable at multidetector CT angiography of the peripheral arteries without compromising image quality and diagnostic performance if acquisition protocols are modified appropriately and used in conjunction with a contrast material containing a high concentration of iodine.
Characterization of Scuba-2 450 μm and 850 μm selected galaxies in the COSMOS field

We present deep 450 μm and 850 μm observations of a large, uniformly covered 394 arcmin2 area in the Cosmic Evolution Survey (COSMOS) field obtained with the SCUBA-2 instrument on the James Clerk Maxwell Telescope (JCMT). We achieve root-mean-square noise values of σ450 = 4.13 mJy and σ850 = 0.80 mJy. The differential and cumulative number counts are presented and compared to similar previous works. Individual point sources are identified at >3. 6σ significance, a threshold corresponding to a 3–5 per cent sample contamination rate. We identify 78 sources at 450 μm and 99 at 850 μm, with flux densities S450 = 13–37 mJy and S850 = 2–16 mJy. Only 62–76 per cent of 450 μm sources are 850 μm detected and 61–81 per cent of 850 μm sources are 450 μm detected. The positional uncertainties at 450 μm are small (1–2.5 arcsec) and therefore allow a precise identification of multiwavelength counterparts without reliance on detection at 24 μm or radio wavelengths; we find that only 44 per cent of 450 μm sources and 60 per cent of 850 μm sources have 24 μm or radio counterparts. 450 μm selected galaxies peak at 〈z〉 = 1.95 ± 0.19 and 850 μm selected galaxies peak at 〈z〉 = 2.16 ± 0.11. The two samples occupy similar parameter space in redshift and luminosity, while their median SED peak wavelengths differ by ∼20–50 μm (translating to ΔTdust = 8–12 K, where 450 μm selected galaxies are warmer). The similarities of the 450 μm and 850 μm populations, yet lack of direct overlap between them, suggests that submillimetre surveys conducted at any single far-infrared wavelength will be significantly incomplete (≳30 per cent) at censusing infrared-luminous star formation at high z.
Antioxidant Capacity and Radical Scavenging Effect of Polyphenol Rich Mallotus philippenensis Fruit Extract on Human Erythrocytes: An In Vitro Study

Mallotus philippinensis is an important source of molecules with strong antioxidant activity widely used medicinal plant. Previous studies have highlighted their anticestodal, antibacterial, wound healing activities, and so forth. So, present investigation was designed to evaluate the total antioxidant activity and radical scavenging effect of 50% ethanol fruit glandular hair extract (MPE) and its role on Human Erythrocytes. MPE was tested for phytochemical test followed by its HPLC analysis. Standard antioxidant assays like DPPH, ABTS, hydroxyl, superoxide radical, nitric oxide, and lipid peroxidation assay were determined along with total phenolic and flavonoids content. Results showed that MPE contains the presence of various phytochemicals, with high total phenolic and flavonoid content. HPLC analysis showed the presence of rottlerin, a polyphenolic compound in a very rich quantity. MPE exhibits significant strong scavenging activity on DPPH and ABTS assay. Reducing power showed dose dependent increase in concentration absorption compared to standard, Quercetin. Superoxide, hydroxyl radical, lipid peroxidation, nitric oxide assay showed a comparable scavenging activity compared to its standard. Our finding further provides evidence that Mallotus fruit extract is a potential natural source of antioxidants which have a protective role on human Erythrocytes exhibiting minimum hemolytic activity and this justified its uses in folklore medicines.
Daytime napping, sleep duration and serum C reactive protein: a population-based cohort study

Objectives To explore whether daytime napping and sleep duration are linked to serum C reactive protein (CRP), a pro-inflammatory marker, in an older aged British population. Design Cross-sectional study. Setting European Prospective Investigation into Cancer and Nutrition (EPIC)-Norfolk study. Participants A total of 5018 men and women aged 48–92 years reported their sleep habits and had serum CRP levels measured. Outcome and measures CRP was measured (mg/L) during 2006–2011 in fresh blood samples using high-sensitivity methods. Participants reported napping habits during 2002–2004, and reported sleep quantity during 2006–2007. Multivariable linear regression models were used to examine the association between napping and log-transformed CRP, and geometric mean CRP levels were calculated. Results After adjustment for age and sex, those who reported napping had 10% higher CRP levels compared with those not napping. The association was attenuated but remained borderline significant (β=0.05 (95% CI 0.00 to 0.10)) after further adjustment for social class, education, marital status, body mass index, physical activity, smoking, alcohol intake, self-reported health, pre-existing diseases, systolic blood pressure, hypnotic drug use, depression and in women-only hormone replacement therapy use. The geometric means (95% CI) of CRP levels were 2.38 (2.29 to 2.47) mg/L and 2.26 (2.21 to 2.32) mg/L for those who reported napping and no napping, respectively. A U-shaped association was observed between time spent in bed at night and CRP levels, and nighttime sleep duration was not associated with serum CRP levels. The association between napping and CRP was stronger for older participants, and among extremes of time spent in bed at night. Conclusions Daytime napping was associated with increased CRP levels in an older aged British population. Further studies are needed to determine whether daytime napping is a cause for systemic inflammation, or if it is a symptom or consequence of underlying health problems.
What makes adoptive family life work? Adoptive parents’ narratives of the making and remaking of adoptive kinship

Adoption theory, policy and practice have undergone considerable change in the period between the introduction of the Adoption Act (1976) and the Adoption and Children Act (2002). In this period, in particular, adoption has increasingly come to be understood within the context of an ethic of 'openness'. This has had implications for the day to day lives of members of the adoption triad, that is, adoptive parents, adoptees and birth family members, and their attempts to 'make adoption work’ across their lifecourse. The thesis draws on theories of family and kinship in order to develop understandings of day to day family practices that emerge in adoptive families and the way these shape and are shaped by adoption discourse. The thesis provides an analysis of local and national statistical data and the biographical accounts of twenty two adoptive parents who had children placed with them between 1977 and 2001. These were all domestic 'stranger' adoptions. From the adopters’ narratives it was apparent that the core and ongoing challenge facing adoptive parents was to find a unique way of 'doing' adoptive family life which acknowledged the importance both of biological ties and legal kinship. This was the ease regardless of the year of the adoption and continues to challenge these families today. The thesis explores the tasks which flow from this core challenge, that is, developing and maintaining family relationships between adopters and adoptees where none previously existed, finding a place for birth relatives within the adoptive kinship model and developing a positive identity as a non conventional family. The thesis challenges the conceptualisation of adoptive relations as 'fictive kinship' and biological connectedness as 'real' kinship and presents evidence of the fragility of both the biological family and the adoptive family where there has been a legal adoption of a child. At the same time the thesis reveals the ability of both biological and adoptive family ties to endure over time despite cultural barriers. The study also reveals that existing typologies of adoption as 'confidential', 'mediated' and 'fully disclosed' fail to capture the complexity of adoptive family life. A new definition of both adoptive kinship and 'openness' in adoption are developed and the implications of these redefinitions for adoption policy and practice are explored
The Hare Psychopathy Checklist-Revised

This invention relates to photographic and photomechanical reproduction work, of the black-and-white or colour process type, and specially to new methods and means for adjusting the contrast between the lights and shades of the image. Basically, the auxiliary or flash exposure and the main exposure are adjusted and effected simultaneously, whereby the amounts of light transmitted by the shades and by the lights, respectively, of the original document have well-defined values. This is obtained by providing, in a photographic reproduction apparatus, a lens assembly comprising, adjacent the variable-aperture opaque diaphragm, a further variable-aperture diaphragm consisting of translucent material. The two diaphragms may have their control levers operatively interconnected for manual operation, or said diaphragms may be automatically operated by means of two photometers disposed in the lights and in the shades, respectively, of the image to be reproduced.
Height and relative leg length as indicators of the quality of the environment among Mozambican juveniles and adolescents

The growth status of Mozambique adolescents was assessed to test the hypothesis that relative leg length is a more sensitive indicator of the quality of the environment than the total height. The sample comprised 690 boys and 727 girls, aged between 9 and 17 years, from Maputo. It is divided between those living in the Centre of Maputo and those living in the slums on the periphery of the city. Height, weight, and sitting height were measured and the sitting height ratio was calculated. The hypothesis that relative leg length is more sensitive than total stature as an indicator of environmental quality is not uniformly confirmed. Overall, mean stature is greater for the centre group than the slum group, but relative leg length as measured by the sitting height ratio does not differ. Compared with African‐American references (NHANES II), all centre girls, 9‐ to 14‐year‐old slum girls, all slum boys, and the oldest centre boys show relatively shorter legs. These findings show that within the Mozambique sample, relative leg length is not sensitive enough to distinguish the quality of the living environment. Mozambique was a colony of Portugal until 1975. Civil unrest and warfare characterized the late Colonial period and the postindependence period until a peace settlement was concluded in 1992. It is possible that all socioeconomic status groups within the country suffered sufficiently to reduce relative leg length compared with the better‐off African‐American reference sample. Possible genetic influences on relative leg length are also discussed. Am. J. Hum. Biol. 2009. © 2008 Wiley‐Liss, Inc.
CFTR mutations in patients from Colombia: Implications for local and regional molecular diagnosis programs

Cystic Fibrosis is a worldwide distributed hereditary disease. The incidence of the main (p.F508del) and other frequent mutations has been determined in a great number of countries and ethnic groups, but its incidence in most Latin American countries has remained unknown until recently. It is now beginning to be recognized as a frequent cause of infant mortality, and some countries report the incidence of their mutations. Colombia started several years ago a concerted program of molecular study of patients which were clinically diagnosed as probable cystic fibrosis. We screened the whole CFTR (ABCC7) coding sequence in 92 patients from 6 different geographic regions, using conventional PAGE analyses and DGGE followed by sequencing. Additionally, we established the frequency of the p.F508del mutation in 130 unrelated healthy controls. The results of this pilot study in Colombian patients from various ethnic admixture show six main mutations: p.F508del (41.8%), c.1811+1.6kbA>G (6.5%), p.G542X (3.8%), p.S549R (2.2%), p.W1282X (1.1%) and p.R1162X (1.1%). Thirteen other rare mutations, including three novel, were detected, accounting for a total of 63.6% known mutations. There is a great variability between the geographic regions, both in the frequency of the p.F508del mutation and non‐p.F508del CF chromosomes. Our results point to a varied origin of the disease genes. These results also show that careful scrutiny of the mutations is needed in each part of Latin America in order to establish priority‐screening protocols adapted to each country and region. © 2003 Wiley‐Liss, Inc.
An Epstein-Barr virus–encoded microRNA targets PUMA to promote host cell survival

Epstein-Barr virus (EBV) is a herpesvirus associated with nasopharyngeal carcinoma (NPC), gastric carcinoma (GC), and other malignancies. EBV is the first human virus found to express microRNAs (miRNAs), the functions of which remain largely unknown. We report on the regulation of a cellular protein named p53 up-regulated modulator of apoptosis (PUMA) by an EBV miRNA known as miR-BART5, which is abundantly expressed in NPC and EBV-GC cells. Modulation of PUMA expression by miR-BART5 and anti–miR-BART5 oligonucleotide was demonstrated in EBV-positive cells. In addition, PUMA was found to be significantly underexpressed in ∼60% of human NPC tissues. Although expression of miR-BART5 rendered NPC and EBV-GC cells less sensitive to proapoptotic agents, apoptosis can be triggered by depleting miR-BART5 or inducing the expression of PUMA. Collectively, our findings suggest that EBV encodes an miRNA to facilitate the establishment of latent infection by promoting host cell survival.
Automatic processing of abstract musical tonality

Music perception builds on expectancy in harmony, melody, and rhythm. Neural responses to the violations of such expectations are observed in event-related potentials (ERPs) measured using electroencephalography. Most previous ERP studies demonstrating sensitivity to musical violations used stimuli that were temporally regular and musically structured, with less-frequent deviant events that differed from a specific expectation in some feature such as pitch, harmony, or rhythm. Here, we asked whether expectancies about Western musical scale are strong enough to elicit ERP deviance components. Specifically, we explored whether pitches inconsistent with an established scale context elicit deviant components even though equally rare pitches that fit into the established context do not, and even when their timing is unpredictable. We used Markov chains to create temporally irregular pseudo-random sequences of notes chosen from one of two diatonic scales. The Markov pitch-transition probabilities resulted in sequences that favored notes within the scale, but that lacked clear melodic, harmonic, or rhythmic structure. At the random positions, the sequence contained probe tones that were either within the established scale or were out of key. Our subjects ignored the note sequences, watching a self-selected silent movie with subtitles. Compared to the in-key probes, the out-of-key probes elicited a significantly larger P2 ERP component. Results show that random note sequences establish expectations of the “first-order” statistical property of musical key, even in listeners not actively monitoring the sequences.
The influence of phosphorus deficiency on growth and nitrogen fixation of white clover plants.

The effects of P deficiency on growth, N(2)-fixation and photosynthesis in white clover (Trifolium repens L.) plants were investigated using three contrasting relative addition rates of P, or following abrupt withdrawal of the P supply. Responses to a constant below-optimum P supply rate consisted of a decline in N(2)-fixation per unit root weight and a small reduction in the efficiency with which electrons were allocated to the reduction of N(2) in nodules. Abrupt removal of P arrested nodule growth and caused a substantial decline in nitrogenase activity per unit root weight, but not per unit nodule mass. Similarly, the rate of photosynthesis per unit leaf area was unaffected by abrupt P removal, whereas CO(2) acquisition for the plant as a whole decreased due to a decline in total leaf area, leaf area per unit leaf weight and utilization of incoming radiation. These changes followed the decline in tissue P concentrations. The ratio between CO(2)-fixation and N(2)-fixation was maintained under short-term P deprivation but increased under long-term low P supply, indicating a regulatory inhibition of nodule activity following morphological and growth adjustments. It is concluded that N(2)-fixation did not limit the growth of clover plants experiencing P deficiency. A low P status induced changes in the relative growth of roots, nodules and shoots rather than changes in N and/or C uptake rates per unit mass or area of these organs.
Residential Radon Exposure and Incidence of Childhood Lymphoma in Texas, 1995–2011

There is warranted interest in assessing the association between residential radon exposure and the risk of childhood cancer. We sought to evaluate the association between residential radon exposure and the incidence of childhood lymphoma in Texas. The Texas Cancer Registry (n = 2147) provided case information for the period 1995–2011. Denominator data were obtained from the United States Census. Regional arithmetic mean radon concentrations were obtained from the Texas Indoor Radon Survey and linked to residence at diagnosis. Exposure was assessed categorically: ≤25th percentile (reference), >25th to ≤50th percentile, >50th to ≤75th percentile, and >75th percentile. Negative binomial regression generated adjusted incidence rate ratios (aIRR) and 95% confidence intervals (CI). We evaluated lymphoma overall and by subtype: Hodgkin (HL; n = 1248), Non-Hodgkin excluding Burkitt (non-BL NHL; n = 658), Burkitt (BL; n = 241), and Diffuse Large B-cell (DLBCL; n = 315). There was no evidence that residential radon exposure was positively associated with lymphoma overall, HL, or BL. Areas with radon concentrations >75th percentile had a marginal increase in DLBCL incidence (aIRR = 1.73, 95% CI: 1.03–2.91). In one of the largest studies of residential radon exposure and the incidence of childhood lymphoma, we found little evidence to suggest a positive or negative association; an observation consistent with previous studies.
School Bag Weight and the Occurrence of Shoulder, Hand/Wrist and Low Back Symptoms among Iranian Elementary Schoolchildren.

BACKGROUND Schoolchildren usually use school bags to carry their school materials. Carry-ing heavy school bags can cause several problems such as musculoskeletal problems among schoolchildren. The aim of this study was to investigate the association between the weight of school bags and the occurrence of low back, shoulder and hand/wrist symptoms among pri-mary school children. METHOD This cross-sectional, descriptive-analytical study was conducted among a sample of 307 elementary school children in Tabriz, Iran. Data were collected using a questionnaire and from measurement of the school bag weight, body weight and height of each participant. Data were analysed using SPSS software. RESULTS The average load carried by schoolchildren was 2.9 kg, representing approximately 10% of the children's body weight. Girls and lower grade children carried a greater percent-age of their body weights. Approximately 86% of the children reported some kind of muscu-loskeletal symptoms. The occurrence of shoulder, wrists/hands, and low back pain among school-children was 70%, 18.5% and 8.7%, respectively. The results of binary logistic regres-sion indicated that the school bag weight (expressed as a percentage of body weight) was only significantly associated with hand/wrist symptoms (P<0.05). Girls were more likely to com-plaint from low back pain than boys were. Age was significantly negatively associated with hand/wrist symptoms. Body mass index was also significantly associated with shoulder symptoms. CONCLUSION The results indicate a high prevalence of musculoskeletal symptoms among elemen-tary schoolchildren. Preventive measures and appropriate guidelines with regard to safe load carriage in schoolchildren are therefore needed to protect this age group.
Computation of 2-D current distribution in superconductors of arbitrary shapes using a new semi-analytical method

This paper presents an original semi-analytical method (SAM) for computing the 2D current distribution in conductors and superconductors of arbitrary shape, discretized in triangular elements. The method is a generalization of the one introduced by Brandt in 1996, and relies on new and compact analytical relationships between the current density (Jx), the vector potential (Ax), and the magnetic flux density (Bx,By), for a linear variation of J over 2D triangular elements. The derivation of these new formulas, which is also presented in this paper, is based on the analytic solution of the 2D potential integral. The results obtained with the SAM were validated successfully using COMSOL Multiphysics, a commercial package based on the finite-element method. Very good agreement was found between the two methods. The new formulas are also expected to be of great interest in the resolution of inverse problems.