Miracle-dz/UniFAR-FTUs huggingface dataset:
Differences in anti-apoptotic and multidrug resistance phenotypes in elderly and young acute myeloid leukemia patients are related to the maturation of blast cells.

BACKGROUND AND OBJECTIVES Elderly patients with acute myeloid leukemia (AML) have a less favorable outcome, which has been related, among other factors, to multidrug resistance (MDR) phenotypes. DESIGN AND METHODS Freshly obtained erythrocyte-lysed bone marrow samples from 150 elderly patients (> 65 years) with de novo AML and 30 younger AML patients were analyzed using a 4-color immunofluorescence technique for quantitative expression of proteins associated with apoptosis (bcl-2, bax, APO2.7) and MDR (P-gp, MRP, LRP) in 3 blast cell subpopulations, defined according to their maturation stage. RESULTS Although a homogeneous CD34+ blast cell population was more frequent in the elderly patients, (25% vs 7%, p=0.02), no statistically significant differences were detected between the two age groups in the expression of either apoptosis- or MDR-associated proteins, except for slightly higher quantities of LRP protein in the more immature CD34+ blast cell subset in the elderly AML cases (p=0.04). Interestingly, when different blast cell populations were compared, immature (CD34+) blast cells were characterized by higher levels of bcl-2 in both age groups and lower levels of APO2.7 in the elderly group. In addition, higher P-gp levels were found in CD34+ blast cells than in CD34-- ones in elderly AML patients. Reactivity for LRP was low in both elderly and younger patients. INTERPRETATION AND CONCLUSIONS In summary, our results suggest that the higher resistance to chemotherapy observed in elderly AML patients could be related to a higher incidence of cases with a CD34+ homogeneous blast cell population, since these blast cells frequently display a more pronounced anti-apoptotic and MDR1 phenotype.
Spectral properties of X-ray bright variable sources in the Taurus molecular cloud

Aims. We analyze 19 bright variable X-ray sources detected in the XMM-Newton Extended Survey of the Taurus Molecular Cloud (XEST), in order to characterize the variations with time of their coronal properties and to derive informations on the X-ray emitting structures. Methods. We performed time-resolved spectroscopy of the EPIC PN and MOS spectra of the XEST sources, using a model with one or two thermal components, and we used the time evolution of the temperatures and emission measures during the decay phase of ares to derive the size of the aring loops. Results. The light curves of the selected sources show di erent types of variability: ares, long-lasting decay or rise through the whole observation, slow modulation or complex are-lik e variability. Spectral analysis shows typical quiescent plasma temperatures of 5 n 10 MK and 15 n 35 MK; the cool component generally remains constant, while the observed ux changes are due to variations of the hot component. During ares the plasma reaches temperatures up to 100 MK and luminosities up to 10 31 erg s 1 . Loop sizes inferred from are analysis are generally smaller than or comparable to the stellar radius.
On the Marginal Utility of Deploying Measurement Infrastructure

Abstract The cost and complexity of deploying measurement infrastructure in the Internet for the purpose of analyzing its structure and behavior is considerable. Basic questions about the {\em utility} of increasing the number of measurements and/or measurement sites have not yet been addressed which has lead to a ``more is better'''' approach to wide-area measurements. In this paper, we quantify the marginal utility of performing wide-area measurements in the context of Internet topology discovery. We characterize topology in terms of nodes, links, node degree distribution, and end-to-end flows using statistical and information-theoretic techniques. We classify nodes discovered on the routes between a set of 8 sources and 1277 destinations to differentiate nodes which make up the so called ``backbone'''' from those which border the backbone and those on links between the border nodes and destination nodes. This process includes reducing nodes that advertise multiple interfaces to single IP addresses. We show that the utility of adding sources goes down significantly after 2 from the persperspective of interface, node, link and node degree discovery. We show that the utility of adding destinations is constant for interfaces, nodes, links and node degree indicating that it is more important to add destinations than sources. Finally, we analyze paths through the backbone and show that shared link distributions approximate a power law indicating that a small number of backbone links in our study are very heavily utilized.
Functional and morphological changes in the quadriceps muscle induced by eccentric training after ACL reconstruction.

OBJECTIVES The purpose of this study was to investigate the contributions of functional and morphological factors in the recovery of the quadriceps muscle after anterior cruciate ligament (ACL) reconstruction. METHODS Nine subjects (31.3±5.8 years) underwent eccentric exercise sessions twice a week for 12 weeks. Quadriceps muscle function was evaluated using an isokinetic dynamometer (isometric and eccentric peak torque) and electromyography (RMS). Morphological changes were measured using magnetic resonance imaging. RESULTS The initial evaluation showed a significant deficit in knee extensor torque in the involved limb and significant muscle atrophy along the length of the quadriceps. EMG activity was lower in all tested situations. Eccentric training significantly increased isokinetic torque (from 199±51 to 240±63, p<0.05, respectively) and quadriceps area, with the greatest hypertrophy in the proximal thigh region (from 169±27 to 189±25.8 cm², p<0.01). The EMG activity of vastus medialis increased after the first six weeks of eccentric training. The increased extensor torque was correlated with quadriceps cross-sectional area (r=0.81, p<0.01) and EMG activity (r=0.69, p<0.05). After twelve weeks of training, there was a correlation only between torque and cross-sectional area (r=0.78, p<0.01). CONCLUSIONS 1) eccentric training proved to be a potent resource for the quadriceps recovery, both morphologically and functionally, 2) the contributions of functional and morphological factors varied according to the length of training.
TensorFlow: A system for large-scale machine learning

TensorFlow is a machine learning system that operates at large scale and in heterogeneous environments. Tensor-Flow uses dataflow graphs to represent computation, shared state, and the operations that mutate that state. It maps the nodes of a dataflow graph across many machines in a cluster, and within a machine across multiple computational devices, including multicore CPUs, general-purpose GPUs, and custom-designed ASICs known as Tensor Processing Units (TPUs). This architecture gives flexibility to the application developer: whereas in previous "parameter server" designs the management of shared state is built into the system, TensorFlow enables developers to experiment with novel optimizations and training algorithms. TensorFlow supports a variety of applications, with a focus on training and inference on deep neural networks. Several Google services use TensorFlow in production, we have released it as an open-source project, and it has become widely used for machine learning research. In this paper, we describe the TensorFlow dataflow model and demonstrate the compelling performance that TensorFlow achieves for several real-world applications.
Nitrogen Nutrition of Trees in Temperate Forests—The Significance of Nitrogen Availability in the Pedosphere and Atmosphere

Nitrogen (N) is an essential nutrient that is highly abundant as N2 in the atmosphere and also as various mineral and organic forms in soils. However, soil N bioavailability often limits the net primary productivity of unperturbed temperate forests with low atmospheric N input. This is because most soil N is part of polymeric organic matter, which requires microbial depolymerization and mineralization to render bioavailable N forms such as monomeric organic or mineral N. Despite this N limitation, many unfertilized forest ecosystems on marginal soil show relatively high productivity and N uptake comparable to agricultural systems. The present review article addresses the question of how this high N demand is met in temperate forest ecosystems. For this purpose, current knowledge on the distribution and fluxes of N in marginal forest soil and the regulation of N acquisition and distribution in trees are summarized. The related processes and fluxes under N limitation are compared with those of forests exposed to high N loads, where chronic atmospheric N deposition has relieved N limitation and caused N saturation. We conclude that soil microbial biomass is of decisive importance for nutrient retention and provision to trees both in high and low N ecosystems.
Perception of Time in Articulated Visual Events

Perceived duration of a sensory event often exceeds its actual duration. This phenomenon is called time dilation. The distortion may occur because sensory systems are optimized for perception within their respective modalities and not for perception of time. We investigated how the dilation of visual events depends on the duration and content of events. Observers compared the durations of two successive visual stimuli while the luminance of one of the stimuli was modulated at different temporal frequencies. Time dilation correlated with the frequency of modulation and the duration of the stimulus: the faster the modulation and the longer the stimulus duration, the larger the dilation. Notably, time dilation was also accompanied by a decreased sensitivity to stimulus duration. We show that these results are consistent with the notion that stimulus duration is estimated using measurement intervals of the lengths that depend on stimulus frequency content. Estimation of temporal frequency content is more precise using longer measurement intervals, whereas estimation of temporal location is more precise using shorter ones. As a result, visual perception will benefit from using longer intervals when the stimulus is modulated so that its frequency content is measured more precisely. A side effect of using longer temporal intervals is a larger uncertainty about the timing of stimulus offset (temporal location), ensuing time dilation and the reduction of sensitivity to duration. Our findings support the view that time dilation follows from basic principles of measurement and from the notion that visual systems are optimized for visual perception rather than for perception of time.
Multipurpose Public Displays: How Shortcut Menus Affect Usage

Transitioning from bespoke, single-purpose public displays to generic, multipurpose ones entails a number of research challenges. One such challenge is understanding how to group and present available applications to users and what effect this grouping has on application use. This study of an iterative, longitudinal deployment of a multipurpose public display examines two mechanisms that help users find the available applications: a quick-launch menu and a browsable application directory. Using the measures of relative and absolute utility, the study reveals these mechanisms' complex effects on application usage. It also addresses whether a public display should promote popular or unpopular applications.
A computationally efficient non-parabolic bandstructure model for quantum transport simulations

With the increased focus on III-V materials as potential candidates for next-generation nanotransistors advanced bandstructure models going beyond the parabolic band approximation are required to ensure accurate device simulations. For that purpose we present in this paper a quantum transport approach that relies on the effective mass approximation extended with a non-parabolic (NP) correction of the electron bandstructure. This scheme does not only properly account for the NP effects present in the thermionic current of transistors, but also in their source-to-drain tunneling leakage. The NP model is validated by simulating an In0.53Ga0. 47As double-gate ultra-thin-body transistor with different gate lengths ranging from 15 down to 5 nm. An excellent agreement with full-band results is demonstrated in all the cases.
Paradoxical progression of atherosclerosis related to low-density lipoprotein reduction and exposure to ezetimibe.

AIMS Ezetimibe reduces low-density lipoprotein cholesterol (LDL-C) but has complex actions on cholesterol transport and metabolism, and thus, LDL-C reduction may not solely define its overall effects. We explored the relationship between treatment effects and cumulative exposure to ezetimibe, with its effects on carotid intima-media thickness (CIMT) in ARBITER 6-HALTS. METHODS AND RESULTS This analysis includes the 159 patients randomized to ezetimibe within ARBITER 6-HALTS that completed the final imaging endpoint assessment. Eligibility criteria for ARBITER 6-HALTS included known coronary artery disease (CAD) or high risk for coronary heart disease, and treatment with a statin with LDL-C <100 mg/dL and high-density lipoprotein cholesterol <50 or 55 mg/dL for men and women, respectively. The mean CIMT was measured in the far wall of the distal common carotid artery. We analysed the univariate and multivariate relationships of the change in CIMT with baseline characteristics, on-treatment effects, and cumulative ezetimibe exposure (treatment duration × dose × adherence). Ezetimibe reduced LDL-C from 84 ± 23 to 66 ± 20 mg/dL. No net effect on CIMT was observed (baseline CIMT 0.898 ± 0.151 mm; net change -0.002 mm; P = 0.52). There was an inverse relationship between LDL-C and change in CIMT such that greater reductions in LDL-C were associated with greater CIMT progression (r = -0.266; P < 0.001). Change in CIMT also had univariate associations with baseline LDL-C, triglycerides (TG), high-sensitive C-reactive protein, and systolic blood pressure and was directly associated with the change in TG and inversely associated with the change in high-sensitive C-reactive protein. Multivariable models controlling for change in LDL-C, cumulative ezetimibe exposure, and baseline and on-treatment variables showed that both increased LDL-C reduction (P = 0.005) and cumulative drug exposure (P = 0.02) were associated with ezetimibe-associated CIMT progression. CONCLUSION Among CAD and high-risk patients on statin therapy in the ARBITER-6 trial, ezetimibe leads to paradoxical progression of CIMT in association with both greater LDL-C reduction and cumulative drug exposure. These findings may suggest the presence of off-target actions of ezetimibe. TRIAL REGISTRATION ClinicalTrials.gov number: NCT00397657.
Chronic swimming reverses cardiac dysfunction and myosin abnormalities in hypertensive rats.

The purpose of this study was to determine whether a chronic swimming program could reverse the decreased cardiac function and altered myosin biochemistry found in hearts of rats with established renal hypertension. Ten wk after the onset of hypertension [midpoint (m)], hearts from normotensive controls (C) and hypertensives (H) were studied in an isolated working heart apparatus, and myosin biochemistry was analyzed. Half of the control and hypertensive animals were then subjected to a 10-wk swimming program (Sw) and their hearts were compared with those from age-matched sedentary rats. Body weight was no different at the midpoint of the study between Cm and Hm or at the end point (e) of the study among Ce, Swe, He, or H-Swe. Swimming had no effect on blood pressure in either normotensive or hypertensive rats. Dry heart weight was increased by 46% in Hm compared with Cm and by 36% in He, 21% in Swe, and 61% in H-Swe when compared with Ce. Hypertension was associated in both the mid- and end-point studies, with decreases in coronary flow, stroke work (both per gram left ventricle), ejection fraction, and midwall fractional shortening. In addition, actin-activated myosin adenosinetriphosphatase (ATPase) activity was decreased in Hm and He associated with an increase in the content of the V3 myosin isoenzyme. Although the coronary deficit was not corrected in H-Swe, stroke work, ejection fraction, and fractional midwall shortening were normalized compared with control hearts. Myosin ATPase activity and the myosin isoenzyme distribution were similarly restored in H-Swe. (ABSTRACT TRUNCATED AT 250 WORDS)
Myofibroblastic Differentiation in Simple Peritoneal Sclerosis

Objective To analyze the presence of myofibroblasts in a series of peritoneal dialysis (PD) patients with simple sclerosis and non-PD, uremic patients. Since there is a close correlation between active fibrosis and myofibroblastic differentiation we wanted to test if myofibroblasts are present in uremic, non-PD peritoneal samples. To determine if there are correlations between myofibroblastic presence and other functional and morphologic peritoneal parameters. Methods Biopsies were collected from three patient groups: 1) Normal control samples (n=15) of parietal and visceral peritoneum 2) non-PD uremic patients (n=16); and 3) uremic patients on PD (n=32). Peritoneal morphologic and functional parameters and immunohistochemical expression of α-smooth muscle actin was analyzed in each case. Vascular endothelial growth factor (VEGF), bcl-2 anti-apoptotic protein, and progesterone receptor was evaluated in a subset of cases. Results Myofibroblasts were present in 56.3% of the patients with PD-related simple sclerosis. In most cases they were distributed in the upper submesothelial area. None of the biopsies from normal controls and uremic, non-PD patients showed myofibroblasts. Within the group of PD patients, myofibroblasts showed no correlation with time on dialysis, urea/creatinine MTAC, episodes of peritonitis, submesothelial thickening, hyalinizing vasculopathy or mesothelial status. In a subset of PD patients VEGF expression was observed in submesothelial fibroblastic cells. No expression of progesterone receptor or bcl-2 was observed. Conclusions Myofibroblasts are a reliable and simple indicator of fibrosis since they appear in early stages of PD treatment and in patients with minor morphologic anomalies. They are not exclusive of patients with sclerosing peritonitis, ultrafiltration loss or long standing treatment. Their absence in non-PD, uremic patients suggest that uremia-related fibrosis takes place without a significant participation of myofibroblasts.
Analysis of combinatorial effects of Wnts and Frizzleds on β‐catenin/armadillo stabilization and Dishevelled phosphorylation

Both Wnt ligands and Frizzled (Fz) receptors each constitute a large family in vertebrates, but the receptor specificity of each Wnt has remained largely unknown. Here, we examined the receptor specificity of two typical Wnts, Wnt‐3a and Wnt‐5a, in signal transmission. To investigate systematically the combinatorial effects of these Wnts, various Fzs on canonical Wnt/β‐catenin signaling, we analyzed the ability of these Wnt proteins to increase stability of armadillo/β‐catenin proteins in Drosophila S2 cells expressing vertebrate Fzs. Wnt‐3a increases the amount of armadillo proteins in cells expressing Fzs 4, 5 and 8, but not Fzs 3 and 6; whereas Wnt‐5a does not increase it in any cell line. In contrast, both Wnt‐3a and Wnt‐5a increase the phosphorylation of Dsh in combination with most of the Fzs. This Dsh phosphorylation is abrogated by decreasing the levels of casein kinase I α by double‐stranded RNA‐mediated translational interference. These observations indicate that both Wnt proteins can interact with the majority of Fz receptors and elicit signaling reactions exemplified by Dsh phosphorylation but that the stabilization of β‐catenin/armadillo proteins in the Wnt/β‐catenin signaling occurs only when specific combinations of Wnt and Fz meet.
The impact of lower urinary tract symptoms and urinary incontinence on female sexual dysfunction using a validated instrument.

INTRODUCTION Lower urinary tract symptoms (LUTS) is a common problem in women and frequently coexists with female sexual dysfunction (FSD). However, the relationship of LUTS and FSD is poorly characterized. AIM To evaluate the relationship of LUTS and urinary incontinence (UI) to FSD using a validated instrument, the female sexual function index (FSFI). METHODS We performed an institutional review board-approved retrospective evaluation of 236 female patients over a 3-year time-period who completed an FSFI-validated questionnaire and underwent urodynamics (UDS) evaluation for LUTS or UI. Patients were categorized based upon history and physical exam into different LUTS groups. Additionally, the presence or absence of UI, detrusor overactivity (DO), stress urinary incontinence, and maximal cystometric capacity (MCC) > or <200 mL on UDS were used to further evaluate these patients. FSFI domain and total scores were compared between the different LUTS groups. MAIN OUTCOME MEASURE FSFI scores were evaluated for women with similar clinical LUTS diagnosis and UDS findings. The Kruskal-Wallis nonparametric test and the Dwass-Steel test determined statistical significance and performed multiple pairwise comparisons between the different voiding dysfunction groups and those with normal UDS (Leak-/DO-/urodynamic stress incontinence-). RESULTS The mean age of the cohort was 49.5 (range 18-69), and there was no statistically significant difference in mean age within each LUTS subgroup. MCC < 200 mL did not significantly impair female sexual function. Patients with clinical diagnosis of overactive bladder (OAB)-Dry had the highest sexual function while those with mixed urinary incontinence had the worst. Additionally, women with UI and DO had the greatest degree of FSD, which was significantly worse than those with normal UDS. Additionally, for women with or without UI, the presence of DO on UDS resulted in a trend toward worse sexual function. CONCLUSIONS The sexual function of women is negatively impacted by the presence of LUTS, with UI and DO causing the greatest degree of FSD. The sexual domains most affected are desire, lubrication, orgasm, and sexual satisfaction.
Chewing lice (Phthiraptera) from wild birds in Senegal, with descriptions of three new species of the genera Brueelia and Philopteroides

A total of 170 wild birds from Senegal, belonging to 48 species and 9 orders, were searched for lice in 2005 and 2007. Chewing lice were found on 58 birds of 18 species and 5 orders (Columbiformes, Cuculiformes, Coraciiformes, Galliformes and Passeriformes). Twenty-two species of chewing lice of 13 genera were determined. Other nine samples of chewing lice that represent a new host-parasite association were determined at generic level only, because only one sex or nymph of these lice were found. Our records represent the first louse records from passerines Camaroptera brachyura (Cisticolidae), Chalcomitra senegalensis (Nectariniidae), Corvinella corvina (Laniidae), Laniarius barbarus (Malaconotidae), Prinia erythroptera (Cisticolidae) and Turdus pelios (Turdidae). Descriptions and illustrations are given for Brueelia chalcomitrae Najer et Sychra sp. nov. ex Chalcomitra senegalensis (Nectariniidae), Brueelia priniae Najer et Sychra sp. nov. ex Prinia subflava (Cisticolidae), and Philopteroides terpsiphoni Najer et Sychra sp. nov. ex Terpsiphone viridis (Monarchidae).