Miracle-dz/UniFAR-FTUs huggingface dataset:
Prognostic value of CD44 variant 6 in laryngeal epidermoid carcinomas.

BACKGROUND CD44 variant exon 6 (v6) belongs to a family of transmembrane glycoproteins involved in cell adhesion. OBJECTIVES To determine the prognostic role of CD44v6 in laryngeal cancer and to examine its relation with other clinicopathologic prognostic factors. DESIGN A retrospective cohort study was designed with 93 laryngeal cancer cases. They were selected randomly from patients treated with laryngectomy between January 1, 1983, and December 31, 1993. SETTING Faculty of Medicine, Hacettepe University, Ankara, Turkey. PATIENTS The ages of the patients ranged from 31 to 73 years. Eighty-eight patients were men and 5 were women. Three had stage I, 33 had stage II, 27 had stage III, and 30 had stage IV disease at the time of surgery. INTERVENTION Histological sections of tumors and metastatic lymph nodes were reevaluated for several histopathological factors. Sections were stained using anti-CD44v6 monoclonal antibody by immunohistochemical methods. RESULTS CD44v6 expression was seen only in the lower one third of the normal squamous epithelium but in all layers of dysplasia and in situ carcinoma. Besides a general evaluation of tumor staining, immunostaining was evaluated separately for cell groups located in the center of neoplastic islands (nonbasal cells), at the periphery of the neoplastic islands (basal cells), and at the infiltration zones (marginal cells). Decreased disease-free survival was noted when there was extensive staining in the general evaluation and in cases with extensive staining in marginal and nonbasal cells (P =.03). Using Cox regression analysis, the greatest dimension of the largest metastatic lymph node and extensive expression of CD44v6 in nonbasal tumor cells were independent prognostic factors. CONCLUSION Our results suggest that CD44v6 expression is an important prognostic factor in laryngeal cancer.
What Can Survey Forecasts Tell Us About Informational Rigidities?

This paper uses three different surveys of economic forecasts to assess both the support for and the properties of informational rigidities faced by agents. Specifically, we track the impulse responses of mean forecast errors and disagreement among agents after exogenous structural shocks. Our key contribution is to document that in response to structural shocks, mean forecasts fail to completely adjust on impact, leading to statistically and economically significant deviations from the null of full information: the half life of forecast errors is roughly between 6 months and a year. Importantly, the dynamic process followed by forecast errors following structural shocks is consistent with the predictions of models of informational rigidities. We interpret this finding as providing support for the recent expansion of research into models of informational rigidities. In addition, we document several stylized facts about the conditional responses of forecast errors and disagreement among agents that can be used to differentiate between some of the models of informational rigidities recently proposed.
Effect of ZnO on the Physical Properties and Optical Band Gap of Soda Lime Silicate Glass

This manuscript reports on the physical properties and optical band gap of five samples of soda lime silicate (SLS) glass combined with zinc oxide (ZnO) that were prepared by a melting and quenching process. To understand the role of ZnO in this glass structure, the density, molar volume and optical band gaps were investigated. The density and absorption spectra in the Ultra-Violet-Visible (UV-Visible) region were recorded at room temperature. The results show that the densities of the glass samples increased as the ZnO weight percentage increased. The molar volume of the glasses shows the same trend as the density: the molar volume increased as the ZnO content increased. The optical band gaps were calculated from the absorption edge, and it was found that the optical band gap decreased from 3.20 to 2.32 eV as the ZnO concentration increased.
Sorafenib Potently Inhibits Papillary Thyroid Carcinomas Harboring RET/PTC1 Rearrangement

Purpose: Papillary thyroid carcinomas (PTC) are the most common type of thyroid malignancy with one of the two mutations, RET/PTC rearrangement or BRAF mutation. Both mutations are able to activate the MEK/ERK signaling transduction pathway and result in the activation of transcription factors that regulate cellular proliferation, differentiation, and apoptosis. Sorafenib (Nexavar, BAY 43-9006) is a multikinase inhibitor, and in this study, we tested its effects on PTC cells carrying either mutation. Experimental Design: The effects of sorafenib on cell proliferation and signaling were evaluated in vitro on PTC cells using growth curves, cell cycle analysis, and immunoblotting. Using an orthotopic mouse model, we determined the antitumor effects of sorafenib in vivo. Results: The concentration needed for 50% growth inhibition (GI50) by sorafenib was 0.14 μmol/L for the PTC cells with the RET/PTC1 rearrangement, and 2.5 μmol/L for PTC cells with a BRAF mutation, both readily achievable serum concentrations. After 3 weeks of oral administration of sorafenib (80 mg/kg/d) in mice, small (94% reduction compared with controls) or no tumor growth was detected in mice inoculated with PTC cells bearing the RET/PTC1 rearrangement, whereas the tumor volume of the orthotopic tumor implants of PTC cells with a BRAF mutation was reduced 53% to 54% (as compared with controls). Conclusions: PTC cells carrying the RET/PTC1 rearrangement were more sensitive to sorafenib than PTC cells carrying a BRAF mutation. Because RET/PTC rearrangements are unique to thyroid carcinomas, our findings support the clinical evaluation of sorafenib for patients with PTC and the identification of patients most likely to respond to sorafenib treatment.
Sentence Context, Word Recognition, and Repetition Blindness

When the sentence She ran her best time yet in the rice last week is displayed using rapid serial visual presentation, viewers sometimes misread rice as race (M. Seven experiments combined misreading and repetition blindness (RB) paradigms to determine whether misreading of a word because of biasing sentence context represents a genuine perceptual effect. In Experiments 1– 4, misreading a word either caused or prevented RB for a downstream word, depending on whether orthographic similarity was increased or decreased. Additional experiments examined temporal parameters of misreading RB and tested the hypothesis that RB results from reconstructive memory processes. Results suggest that the effect of prior context occurs during perception. Questions concerning the role of sentence context in the process of visual word recognition continue to be some of the most contentious in the field of cognitive psychology. Although the idea that sentence context can influence visual word recognition is widely accepted, there is considerable controversy over just how, and when, context has its effects. Competing models of word recognition can be broadly classified as modular or interactive, with the role of sentence context providing a crucial difference between the two types. In modular models (e.g., Fodor, 1983; Forster, 1979), word recognition is strictly a bottom-up process; it is solely dependent on stimulus information and impervious to the influence of higher-level context. Sentence context influences postperceptual stages, such as integration of the word with the remainder of the sentence. However, context can also fill in when the perceptual module fails to identify a word, as may occur under degraded conditions. Modular models account for the well-documented effects of semantic priming on lexical access by positing that spreading activation between associated word representations occurs entirely within the lexical module. In contrast, interactive models propose that constraints arising from sentence context combine with stimulus information during early stages in word recognition, even before the perceptual module has completed its identification of the word. In some interactive models, information from higher levels (i.e., sentence context) feeds back to influence processing at lower levels such as visual feature analysis and activation of lexical candidates (e.g., McClel-land & Rumelhart, 1981). Hybrid models, or modular-interactive models (e. preserve the principle of autonomy while accounting for the facilitative effects of sentence context. In the modular-interactive model of word recognition proposed by Potter et al. (1993), the first, autonomous stage outputs a set of word candidates (generally orthographic neighbors …
An Online Sequence-to-Sequence Model Using Partial Conditioning

Sequence-to-sequence models have achieved impressive results on various tasks. However, they are unsuitable for tasks that require incremental predictions to be made as more data arrives. This is because they generate an output sequence conditioned on an entire input sequence. In this paper, we present a new model that can make incremental predictions as more input arrives, without redoing the entire computation. Unlike sequence-to-sequence models, our method computes the next-step distribution conditioned on the partial input sequence observed and the partial sequence generated. It accomplishes this goal using an encoder recurrent neural network (RNN) that computes features at the same frame rate as the input, and a transducer RNN that operates over blocks of input steps. The transducer RNN extends the sequence produced so far using a local sequence-to-sequence model. During training, our method uses alignment information to generate supervised targets for each block. Approximate alignment is easily available for tasks such as speech recognition, action recognition in videos, etc. During inference (decoding), beam search is used to find the most likely output sequence for an input sequence. This decoding is performed online - at the end of each block, the best candidates from the previous block are extended through the local sequence-to-sequence model. On TIMIT, our online method achieves 19.8% phone error rate (PER). For comparison with published sequence-to-sequence methods, we used a bidirectional encoder and achieved 18.7% PER compared to 17.6% from the best reported sequence-to-sequence model. Importantly, unlike sequence-to-sequence our model is minimally impacted by the length of the input. On artificially created longer utterances, it achieves 20.9% with a unidirectional model, compared to 20% from the best bidirectional sequence-to-sequence models.
Relationships between Flow, Self-Concept, Psychological Skills, and Performance

The main purpose of this study was to examine psychological factors of potential relevance to athletic flow experiences. A secondary purpose was to empirically examine the relationship between flow and optimal performance. Understanding factors that may be associated with flow will help to make this optimal mental state more accessible to researchers and practitioners. Self-concept and use of psychological skills were predicted to be related to self-reported flow states. Competitive athletes across three sports completed dispositional assessments of athletic self-concept, psychological skills, and flow. The athletes also completed a post-event flow assessment, as well as other questions relating to their performance, after a specified competitive event. Positive relationships were found between flow and aspects of self-concept, and the relationships between flow and psychological skills use were also in the expected directions. In addition, the predicted positive relationship between a post-event flow assessment and performance criteria was obtained. This study builds on earlier research that has investigated antecedents of flow, and contributes to the expanding knowledge base of psychological factors related to optimal experience and performance.
Promyelocytic Leukemia Protein Is Redistributed during the Formation of Intranuclear Inclusions Independent of Polyglutamine Expansion: An Immunohistochemical Study on Marinesco Bodies

Marinesco bodies (MBs) are ubiquitinated intranuclear inclusions observed in nigral pigmented neurons. They increase in number during aging, and their formation is considered to represent a cellular reaction to stress, but is not always associated with neuronal degeneration. We conducted immunohistochemical studies on MBs abundant in myotonic dystrophy brains and compared their nature with that of neuronal intranuclear inclusions (NIIs) in polyglutamine diseases. First, we examined the relationship between MBs and polyglutamine proteins and demonstrated that one of the polyglutamine proteins, ataxin-3, as well as a 19S proteasomal protein, was preferentially recruited into MBs even in the absence of expanded polyglutamine. This indicates that an alternative mechanism during the formation of MBs that is not related to polyglutamine expansion or neuronal degeneration may recruit ataxin-3 into nuclear inclusions in a protein-specific manner. Secondly, we investigated the relationship between MBs and promyelocytic leukemia protein (PML), a nuclear matrix-associated protein that is normally localized to intranuclear punctate structures (PML nuclear bodies) and is known to reorganize itself in association with polyglutamine aggregation. In nigral pigmented neurons in myotonic dystrophy, spherical, hemispherical or rod-like PML-immunoreactive structures, in addition to punctate structures, were observed in their nuclei. Similar PML redistribution was also observed in nigral pigmented neurons in aged controls and cases of hepatic encephalopathy, 2 other conditions in which abundant MBs are formed. Double immunofluorescence study revealed that these PML-positive structures undergo morphological changes in association with ubiquitin accumulation during MB formation. It is therefore indicated that PML reorganization does not represent a specific nuclear event involved in the pathogenesis of polyglutamine diseases, but may commonly occur during the formation of intranuclear inclusions as a reaction against various stresses that involve the ubiquitin-proteasome pathway.
Functional Characterization of Alternative Splicing in the C Terminus of L-type CaV1.3 Channels*

Background: Alternative splicing generates calcium channel splice variants with altered electrophysiological properties. Results: Exclusion of exons encoding the IQb domain or proximal/distal domains attenuates Ca2+-dependent inactivation of the CaV1.3 channels. Conclusion: Alternative splicing at the C terminus alters the critical Ca2+ inhibitory feedback property of CaV1.3 channels. Significance: Alternative splicing is an exquisite mechanism for customizing channel function within diverse biological niches. CaV1.3 channels are unique among the high voltage-activated Ca2+ channel family because they activate at the most negative potentials and display very rapid calcium-dependent inactivation. Both properties are of crucial importance in neurons of the suprachiasmatic nucleus and substantia nigra, where the influx of Ca2+ ions at subthreshold membrane voltages supports pacemaking function. Previously, alternative splicing in the CaV1.3 C terminus gives rise to a long (CaV1.342) and a short form (CaV1.342A), resulting in a pronounced activation at more negative voltages and faster inactivation in the latter. It was further shown that the C-terminal modulator in the CaV1.342 isoforms modulates calmodulin binding to the IQ domain. Using splice variant-specific antibodies, we determined that protein localization of both splice variants in different brain regions were similar. Using the transcript-scanning method, we further identified alternative splicing at four loci in the C terminus of CaV1.3 channels. Alternative splicing of exon 41 removes the IQ motif, resulting in a truncated CaV1.3 protein with diminished inactivation. Splicing of exon 43 causes a frameshift and exhibits a robust inactivation of similar intensity to CaV1.342A. Alternative splicing of exons 44 and 48 are in-frame, altering interaction of the distal modulator with the IQ domain and tapering inactivation slightly. Thus, alternative splicing in the C terminus of CaV1.3 channels modulates its electrophysiological properties, which could in turn alter neuronal firing properties and functions.
Cortical Pain Responses in Human Infants

Despite the recent increase in our understanding of the development of pain processing, it is still not known whether premature infants are capable of processing pain at a cortical level. In this study, changes in cerebral oxygenation over the somatosensory cortex were measured in response to noxious stimulation using real-time near-infrared spectroscopy in 18 infants aged between 25 and 45 weeks postmenstrual age. The noxious stimuli were heel lances performed for routine blood sampling; no blood tests were performed solely for the purpose of the study. Noxious stimulation produced a clear cortical response, measured as an increase in total hemoglobin concentration [HbT] in the contralateral somatosensory cortex, from 25 weeks (mean Δ[HbT] = 7.74 μmol/L; SE, 1.10). Cortical responses were significantly greater in awake compared with sleeping infants, with a mean difference of 6.63 μmol/L [95% confidence interval (CI) limits: 2.35, 10.91 μmol/L; mean age, 35.2 weeks]. In awake infants, the response in the contralateral somatosensory cortex increased with age (regression coefficient, 0.698 μmol/L/week; 95% CI limits: 0.132, 1.265 μmol/L/week) and the latency decreased with age (regression coefficient, −0.9861 μmol/L/week; 95% CI limits: −1.5361, −0.4361 μmol/L/week; age range, 25–38 weeks). The response was modality specific because no response was detected after non-noxious stimulation of the heel, even when accompanied by reflex withdrawal of the foot. We conclude that noxious information is transmitted to the preterm infant cortex from 25 weeks, highlighting the potential for both higher-level pain processing and pain-induced plasticity in the human brain from a very early age.
An Accurate Non-Cooperative Method for Measuring Textureless Spherical Target Based on Calibrated Lasers

Strong demands for accurate non-cooperative target measurement have been arising recently for the tasks of assembling and capturing. Spherical objects are one of the most common targets in these applications. However, the performance of the traditional vision-based reconstruction method was limited for practical use when handling poorly-textured targets. In this paper, we propose a novel multi-sensor fusion system for measuring and reconstructing textureless non-cooperative spherical targets. Our system consists of four simple lasers and a visual camera. This paper presents a complete framework of estimating the geometric parameters of textureless spherical targets: (1) an approach to calibrate the extrinsic parameters between a camera and simple lasers; and (2) a method to reconstruct the 3D position of the laser spots on the target surface and achieve the refined results via an optimized scheme. The experiment results show that our proposed calibration method can obtain a fine calibration result, which is comparable to the state-of-the-art LRF-based methods, and our calibrated system can estimate the geometric parameters with high accuracy in real time.
An Amperometric Glucose Biosensor Based on Glucose Oxidase Immobilized in Electropolymerized Poly(o-aminophenol) and Carbon Nanotubes Composite Film on a Gold Electrode

An amperometric glucose biosensor is developed that is based on immobilization of glucose oxidase (GOD) in a composite film of poly( o -aminophenol) (POAP) and carbon nanotubes (CNT), which are electrochemically co-polymerized at a gold (Au) electrode. Because of the high surface per volume ratio and excellent electrical conductivity of CNT, the biosensor based on an Au/POAP/CNT/GOD electrode has lower detection limit (0.01 mM), larger maximum response current (0.24 mA cm^–2) and higher sensitivity (11.4 mA M^–1 cm^–2) than the values of the biosensor based on an Au/POAP/GOD electrode. Additionally, the biosensor shows fast response time, large response current, and good anti-interferent ability for ascorbic acid, uric acid and acetaminophen. Good reproducibility and stability of the biosensor are also observed.
Developmental Changes in Mental Rotation: A Dissociation Between Object-Based and Egocentric Transformations

The present study was conducted to investigate developmental changes of mental rotation performance. We compared children, adults, and older adults regarding their performance in object-based and egocentric transformations. Both children and older adults showed higher overall reaction times compared to adults. Results were interpreted against the background of impaired working memory capacity in both children and older adults. Since mental changes in working memory are mediated by age differences in cognitive processing speed, cognitive speed is supposed to be the underlying factor. Regarding both types of transformations, an advantage of egocentric over object-based human figures was only found in adults which led us to tentatively propose that children and older adults show deficits in perspective taking compared to adults.
A Simple Acoustic Method for Modal Parameter Measurement of the Resonator for Vibratory Shell Gyroscope

In this paper, an acoustic method measuring the frequency split, quality factor and modal deflection of the resonator for vibratory shell gyroscope (VSG) is presented. This method is based on the superposition and decomposition of acoustic waves generated by standing wave eigenmodes of the resonator. The acoustic signals from an imperfect resonator comprise two standing waves of different frequencies and orientations. Theoretical study shows that the oscillating period and trough-peak ratio of the composite acoustic wave are strongly related to the modal parameters of the resonator. Therefore, the modal parameters of the resonator can be obtained via parameter fitting of the acoustic signal. The measurement error due to vibration drift is also analyzed in the theoretical study. The proposed method could be a simple and fast way to measure the main modal parameters of the VSG resonators without using sophisticated or costly equipments. Experiments were implemented to identify the modal parameters of a typical cylindrical resonator using the acoustic method. For the sake of comparison, traditional electrical and optical methods were also employed to measure the modal parameters. The experimental results show that the modal parameters measured by the acoustic method are close to those obtained from the traditional methods.