Miracle-dz/UniFAR-FTUs huggingface dataset:
A Novel Complex Event Processing Monitoring Framework using RFID

Complex Event Processing (CEP) is the most favorable platform to build and to execute multiple numbers of real-time applications. CEP performs processing of the large number of real-time events to trigger a suitable action. CEP systems can handle a large number of concurrent queries with high scalability. CEP may be used to identify moving objects with the Radio Frequency Identification Device (RFID) tag and to make appropriate treatment based on location and other information. In the proposed Novel Complex Event Processing Monitoring Framework (NCEPMF), the input data streams are provided by the RFID reader which reads the RFID tags, where the readings are prioritized with the help of a buffered priority queue. NCEPMF comprises of the following modules - filtering, interpretation, interpolation and triggering in processing the RFID data stream. The output of the NCEPMF provides information about the location of the tracked object. The proposed NCEPMF is validated using a real-time dataset comprising of blood bag management system. Performance Evaluation shows that the NCEPMF is better than the existing system in terms of the following parameters – Accuracy, Processing time, Throughput and Response time.
Brassica napus TT16 homologs with different genomic origins and expression levels encode proteins that regulate a broad range of endothelium-associated genes at the transcriptional level.

The transcription factor TRANSPARENT TESTA 16 (TT16) plays an important role in endothelial cell specification and proanthocyanidin (PA) accumulation. However, its precise regulatory function with regard to the expression of endothelial-associated genes in developing seeds, and especially in the PA-producing inner integument, remains largely unknown. Therefore, we endeavored to characterize four TT16 homologs from the allotetraploid oil crop species Brassica napus, and systematically explore their regulatory function in endothelial development. Our results indicated that all four BnTT16 genes were predominantly expressed in the early stages of seed development, but at distinct levels, and encoded functional proteins. Bntt16 RNA interference lines exhibited abnormal endothelial development and decreased PA content, while PA polymerization was not affected. In addition to the previously reported function of TT16 in the transcriptional regulation of anthocyanidin reductase (ANR) and dihydroflavonol reductase (TT3), we also determined that BnTT16 proteins played a significant role in the transcriptional regulation of five other genes involved in the PA biosynthetic pathway (P < 0.01). Moreover, we identified two genes involved in inner integument development that were strongly regulated by the BnTT16 proteins (TT2 and δ-vacuolar processing enzyme). These results will better our understanding of the precise role of TT16 in endothelial development in Brassicaceae species, and could potentially be used for the future improvement of oilseed crops.
A cascading mentoring pedagogy in a CS service learning course to broaden participation and perceptions

This study reports on the design, implementation, and evaluation of a service-learning course based on a "cascading mentoring" model linking together the faculty, administration, and undergraduates of an urban university's computer science department with local high school students. We present findings from surveys and post-interviews that illustrate undergraduates' and high school students' experiences in the program and how their perceptions of computing and mentoring changed based upon the outreach. In our discussion, we focus on the institutional and conceptual challenges of implementing the community service course within the university's computer science department, while also highlighting the learning opportunities for streamlining such a model for future iterations.
NFIA Controls Telencephalic Progenitor Cell Differentiation through Repression of the Notch Effector Hes1

The balance between self-renewal and differentiation of neural progenitor cells is an absolute requirement for the correct formation of the nervous system. Much is known about both the pathways involved in progenitor cell self-renewal, such as Notch signaling, and the expression of genes that initiate progenitor differentiation. However, whether these fundamental processes are mechanistically linked, and specifically how repression of progenitor self-renewal pathways occurs, is poorly understood. Nuclear factor I A (Nfia), a gene known to regulate spinal cord and neocortical development, has recently been implicated as acting downstream of Notch to initiate the expression of astrocyte-specific genes within the cortex. Here we demonstrate that, in addition to activating the expression of astrocyte-specific genes, Nfia also downregulates the activity of the Notch signaling pathway via repression of the key Notch effector Hes1. These data provide a significant conceptual advance in our understanding of neural progenitor differentiation, revealing that a single transcription factor can control both the activation of differentiation genes and the repression of the self-renewal genes, thereby acting as a pivotal regulator of the balance between progenitor and differentiated cell states.
Time-lapse observation of cell alignment on nanogrooved patterns

Cells elongate on a surface with nanogrooved (NG) patterns and align along that pattern. Although various models have been proposed for how this occurs, much remains to be clarified. Studies with fixed cells do not lend themselves to answering some of these open questions. In this study, the dynamic behaviours of living mesenchymal stem cells on an NG substrate with a 200 nm groove depth, an 870 nm ridge width and a 670 nm groove width were observed using time-lapse microscopes. We found that filopodia moved as if they were probing the surroundings of the cell protrusion, and then some cell protrusions invaded the probed areas. Cell protrusions that extended perpendicular to the NG direction tended to retract more rapidly than those parallel to the grooves. From these facts, we think that the retracting phase of cell protrusions play a rule in cell alignment along the NG patterns.
The SPF27 Homologue Num1 Connects Splicing and Kinesin 1-Dependent Cytoplasmic Trafficking in Ustilago maydis

The conserved NineTeen protein complex (NTC) is an integral subunit of the spliceosome and required for intron removal during pre-mRNA splicing. The complex associates with the spliceosome and participates in the regulation of conformational changes of core spliceosomal components, stabilizing RNA-RNA- as well as RNA-protein interactions. In addition, the NTC is involved in cell cycle checkpoint control, response to DNA damage, as well as formation and export of mRNP-particles. We have identified the Num1 protein as the homologue of SPF27, one of NTC core components, in the basidiomycetous fungus Ustilago maydis. Num1 is required for polarized growth of the fungal hyphae, and, in line with the described NTC functions, the num1 mutation affects the cell cycle and cell division. The num1 deletion influences splicing in U. maydis on a global scale, as RNA-Seq analysis revealed increased intron retention rates. Surprisingly, we identified in a screen for Num1 interacting proteins not only NTC core components as Prp19 and Cef1, but several proteins with putative functions during vesicle-mediated transport processes. Among others, Num1 interacts with the motor protein Kin1 in the cytoplasm. Similar phenotypes with respect to filamentous and polar growth, vacuolar morphology, as well as the motility of early endosomes corroborate the genetic interaction between Num1 and Kin1. Our data implicate a previously unidentified connection between a component of the splicing machinery and cytoplasmic transport processes. As the num1 deletion also affects cytoplasmic mRNA transport, the protein may constitute a novel functional interconnection between the two disparate processes of splicing and trafficking.
Hunting behaviour in West African forest leopards

The leopard (Panthera pardus) is a major predator of mammals within the rainforest ecosystem of West Africa. Most of the available information on leopard hunting behaviour comes from studies conducted in open savannah habitats, while little is known about forest leopards. Our radio-tracking data and scat analysis show that forest leopards differ in various ways from the savannah populations. Forest leopards are diurnal and crepuscular hunters who follow the activity pattern of their prey species. They exhibit seasonal differences in activity patterns, and they develop highly individualized prey preferences. These findings challenge the widespread notion of leopards as opportunistic nocturnal predators.
Antepartum and Intrapartum Factors Preceding Neonatal Hypoxic-Ischemic Encephalopathy

OBJECTIVE: To determine whether antepartum factors alone, intrapartum factors alone, or both in combination, are associated with term neonatal hypoxic-ischemic encephalopathy (HIE). METHODS: A total of 405 infants ≥35 weeks’ gestation with early encephalopathy, born between 1992 and 2007, were compared with 239 neurologically normal infants born between 1996 and 1997. All cases met criteria for perinatal asphyxia, had neuroimaging findings consistent with acute hypoxia-ischemia, and had no evidence for a non–hypoxic-ischemic cause of their encephalopathy. RESULTS: Both antepartum and intrapartum factors were associated with the development of HIE on univariate analysis. Case infants were more often delivered by emergency cesarean delivery (CD; 50% vs 11%, P < .001) and none was delivered by elective CD (vs 10% of controls). On logistic regression analysis only 1 antepartum factor (gestation ≥41 weeks) and 7 intrapartum factors (prolonged membrane rupture, abnormal cardiotocography, thick meconium, sentinel event, shoulder dystocia, tight nuchal cord, failed vacuum) remained independently associated with HIE (area under the curve 0.88; confidence interval 0.85–0.91; P < .001). Overall, 6.7% of cases and 43.5% of controls had only antepartum factors; 20% of cases and 5.8% of controls had only intrapartum factors; 69.5% of cases and 31% of controls had antepartum and intrapartum factors; and 3.7% of cases and 19.7% of controls had no identifiable risk factors (P < .001). CONCLUSIONS: Our results do not support the hypothesis that HIE is attributable to antepartum factors alone, but they strongly point to the intrapartum period as the necessary factor in the development of this condition.
Palmar dermatoglyphics of modern Ukrainians: regional trends

Strengthening of global migration processes, often accompanied by an increase in crime and an increase in the number of unidentified individuals, necessitates the expansion of the use of indirect identification methods. In our opinion, involving dermatoglyphic analysis in cases of unidentified persons would help in forensic medical identification of the ethno-territorial membership of an unknown person. The purpose of the work is to identify a taxonomic complex of features of palmar dermatoglyphics at the local level that allow differentiating the regional affiliation of men in Ukraine. The study of dermatoglyphics of 400 virtually healthy men from 5 administrative-territorial regions of Ukraine was conducted using the method of H. Cummins and Ch. Midlo. Statistical processing of the results was carried out in the package “STATISTICA 6.1” using nonparametric methods. The set of signs of palmar dermatoglyphic was revealed, showing a high degree of heterogeneity between men from the following administrative-territorial regions of the country: central and eastern (20.0% of indicators), central and northern (16.9% of indicators), northern and western (16.9% of indicators), western and eastern (15.4% of the indicators) regions of Ukraine. Men from the northern and eastern (6.2% of the indicators), the south and west (6.2% of the indicator) and the southern and eastern (7.7% of the indicators) regions of Ukraine show a significant affinity for the features of palmar dermatoglyphics. In general, the high taxonomic value for intra-population differentiation of the local level have: the localization and saturation of the palm pattern, the size of the palm angles, the presence/absence of additional axial triads, the length of the segment c-t, the Cummins index.
Striatum and pre-SMA facilitate decision-making under time pressure

Human decision-making almost always takes place under time pressure. When people are engaged in activities such as shopping, driving, or playing chess, they have to continually balance the demands for fast decisions against the demands for accurate decisions. In the cognitive sciences, this balance is thought to be modulated by a response threshold, the neural substrate of which is currently subject to speculation. In a speed decision-making experiment, we presented participants with cues that indicated different requirements for response speed. Application of a mathematical model for the behavioral data confirmed that cueing for speed lowered the response threshold. Functional neuroimaging showed that cueing for speed activates the striatum and the pre-supplementary motor area (pre-SMA), brain structures that are part of a closed-loop motor circuit involved in the preparation of voluntary action plans. Moreover, activation in the striatum is known to release the motor system from global inhibition, thereby facilitating faster but possibly premature actions. Finally, the data show that individual variation in the activation of striatum and pre-SMA is selectively associated with individual variation in the amplitude of the adjustments in the response threshold estimated by the mathematical model. These results demonstrate that when people have to make decisions under time pressure their striatum and pre-SMA show increased levels of activation.
Sherlock: Scalable Fact Learning in Images

We study scalable and uniform understanding of facts in images. Existing visual recognition systems are typically modeled differently for each fact type such as objects, actions, and interactions. We propose a setting where all these facts can be modeled simultaneously with a capacity to understand an unbounded number of facts in a structured way. The training data comes as structured facts in images, including (1) objects (e.g., ), (2) attributes (e.g., ), (3) actions (e.g., ), and (4) interactions (e.g., ). Each fact has a semantic language view (e.g., < boy, playing>) and a visual view (an image with this fact). We show that learning visual facts in a structured way enables not only a uniform but also generalizable visual understanding. We propose and investigate recent and strong approaches from the multiview learning literature and also introduce two learning representation models as potential baselines. We applied the investigated methods on several datasets that we augmented with structured facts and a large scale dataset of more than 202,000 facts and 814,000 images. Our experiments show the advantage of relating facts by the structure by the proposed models compared to the designed baselines on bidirectional fact retrieval.
Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer disease.

OBJECTIVE To identify single-nucleotide polymorphisms (SNPs) associated with risk and age at onset of Alzheimer disease (AD) in a genomewide association study of 469 438 SNPs. DESIGN Case-control study with replication. SETTING Memory referral clinics in Canada and the United Kingdom. PARTICIPANTS The hypothesis-generating data set consisted of 753 individuals with AD by National Institute of Neurological and Communicative Diseases and Stroke/Alzheimer's Disease and Related Disorders Association criteria recruited from 9 memory referral clinics in Canada and 736 ethnically matched control subjects; control subjects were recruited from nonbiological relatives, friends, or spouses of the patients and did not exhibit cognitive impairment by history or cognitive testing. The follow-up data set consisted of 418 AD cases and 249 nondemented control cases from the United Kingdom Medical Research Council Genetic Resource for Late-Onset AD recruited from clinics at Cardiff University, Cardiff, Wales, and King's College London, London, England. MAIN OUTCOME MEASURES Odds ratios and 95% confidence intervals for association of SNPs with AD by logistic regression adjusted for age, sex, education, study site, and French Canadian ancestry (for the Canadian data set). Hazard ratios and 95% confidence intervals from Cox proportional hazards regression for age at onset with similar covariate adjustments. RESULTS Unadjusted, SNP RS4420638 within APOC1 was strongly associated with AD due entirely to linkage disequilibrium with APOE. In the multivariable adjusted analyses, 3 SNPs within the top 120 by P value in the logistic analysis and 1 in the Cox analysis of the Canadian data set provided additional evidence for association at P< . 05 within the United Kingdom Medical Research Council data set: RS7019241 (GOLPH2), RS10868366 (GOLPH2), RS9886784 (chromosome 9), and RS10519262 (intergenic between ATP8B4 and SLC27A2). CONCLUSIONS Our genomewide association analysis again identified the APOE linkage disequilibrium region as the strongest genetic risk factor for AD. This could be a consequence of the coevolution of more than 1 susceptibility allele, such as APOC1, in this region. We also provide new evidence for additional candidate genetic risk factors for AD that can be tested in further studies.
Detection of Mycoplasma ovipneumoniae and Pasteurella haemolytica Antigens by an Immunoperoxidase Technique in Pneumonic Ovine Lungs

Four hundred twenty pneumonic lungs from lambs were examined for Mycoplasma ovipneumoniae and Pasteurella haemolytica by an immunoperoxidase technique using an extravidin-biotin-peroxidase complex method in formalin-fixed, paraffin-embedded sections. Histologic examination of tissue sections revealed strong positive reactions in 60.9% and 68.3% of the lungs against M. ovipneumoniae and P. haemolytica, respectively. M. ovipneumoniae and P. haemolytica antigens were observed at the surface and/or within the epithelial cells, macrophages, leucocytes, and bronchiolar exudate. The location of M. ovipneumoniae in the cytoplasm of the epithelial cells and P. haemolytica in the neutrophils was detected immunohistochemically.
Foundations of semantic web databases

The Semantic Web is based on the idea of adding more machine-readable semantics to web information via annotations written in a language called the Resource Description Framework (RDF). RDF resembles a subset of binary first-order logic including the ability to refer to anonymous objects. Its extended version, RDFS, supports reification, typing and inheritance. These features introduce new challenges into the formal study of sets of RDF/RDFS statements and languages for querying them. Although several such query languages have been proposed, there has been little work on foundational aspects. We investigate these, including computational aspects of testing entailment and redundancy. We propose a query language with well-defined semantics and study the complexity of query processing, query containment, and simplification of answers.
Identification of a new class of MDM2 inhibitor that inhibits growth of orthotopic pancreatic tumors in mice.

BACKGROUND & AIMS The oncogene MDM2, which encodes an E3 ubiquitin ligase, is overexpressed in pancreatic cancers and is therefore a therapeutic target. Current inhibitors of MDM2 target the interaction between MDM2 and P53; these would have no effect on cancer cells that do not express full-length P53, including many pancreatic cancer cells. We searched for a compound that specifically inhibits MDM2 itself. METHODS We performed a virtual screen and structure-based design to identify specific inhibitors of MDM2. We tested the activities of compounds identified on viability, proliferation, and protein levels of HPAC, Panc-1, AsPC-1, and Mia-Paca-2 pancreatic cancer cell lines. We tested whether intraperitoneal injections of one of the compounds identified affected growth of xenograft tumors from Panc-1 cells, or orthotopic tumors from Panc-1 and AsPC-1 cells (injected into pancreata), in nude mice. RESULTS We identified a compound, called SP141, which bound directly to MDM2, promoting its auto-ubiquitination and degradation by the proteasome. The compound reduced levels of MDM2 in pancreatic cancer cell lines, as well as their proliferation, with 50% inhibitory concentrations <0.5 μM (0.38-0.50 μM). Increasing concentrations of SP141 induced increasing levels of apoptosis and G2-M-phase arrest of pancreatic cancer cell lines, whether or not they expressed functional P53. Injection of nude mice with SP141 (40 mg/kg/d) inhibited growth of xenograft tumors (by 75% compared with control mice), and led to regression of orthotopic tumors. CONCLUSIONS In a screen for specific inhibitors of MDM2, we identified a compound called SP141 that reduces levels of MDM2 in pancreatic cancer cell lines, as well as their proliferation and ability to form tumors in nude mice. SP141 is a new class of MDM2 inhibitor that promotes MDM2 auto-ubiquitination and degradation. It might be further developed as a therapeutic agent for pancreatic cancer.
Bacterial infection in cirrhotic patients and its relationship with alcohol

TO THE EDITOR: We read with interest the study by Rosa et al. on bacterial infection in cirrhotic patients and its relationship with alcohol (1). Their study included 128 cirrhotic patients, 78 of whom were alcoholic and 50 of whom were nonalcoholic. The infection and mortality rate was greater in alcoholic cirrhotics, but the difference in infection rate did not reach statistical significance. The authors concluded that bacterial infections are more common in cirrhotics irrespective of etiology.
Evidence of disassortative mating in a Tanganyikan cichlid fish and its role in the maintenance of intrapopulation dimorphism

Morphological dimorphism in the mouth-opening direction (‘lefty’ versus ‘righty’) has been documented in several fish species. It has been suggested that this deflection is heritable in a Mendelian one-locus, two-allele fashion. Several population models have demonstrated that lateral dimorphism is maintained by negative frequency-dependent selection, resulting from interactions between predator and prey species. However, other mechanisms for the maintenance of lateral dimorphism have not yet been tested. Here, we found that the scale-eating cichlid fish Perissodus microlepis exhibited disassortative mating, in which reproductive pairings between lefties and righties occurred at higher than expected frequency (p<0.001). A previous study reported that a lefty–righty pairing produces a 1 : 1 ratio of lefty : righty young, suggesting that disassortative mating contributes to the maintenance of lateral dimorphism. A combination of disassortative mating and negative frequency-dependent selection may stabilize lateral dimorphism more than would a single mechanism.