Miracle-dz/UniFAR-FTUs huggingface dataset:
Rhinovirus in Febrile Infants and Risk of Bacterial Infection

HRV detection does not alter the risk of UTI in febrile infants at any age or the risk of invasive infection in those 1 to 28 days old. BACKGROUND: Febrile infants with viral respiratory infections have a reduced risk of bacterial infection compared with virus-negative infants. The risk of concomitant bacterial infection in febrile infants positive for human rhinovirus (HRV) by polymerase chain reaction (PCR) is unknown. METHODS: Infants 1–90 days old managed using the care process model for well-appearing febrile infants and with respiratory viral testing by PCR (RVPCR) in the emergency department or inpatient setting of 22 hospitals in the Intermountain Healthcare system from 2007-2016 were identified. Relative risk (RR) of bacterial infection was calculated for infants with HRV, non-HRV viruses, or no virus detected. RESULTS: Of 10 964 febrile infants identified, 4037 (37%) had RVPCR. Of these, 2212 (55%) were positive for a respiratory virus; 1392 (35%) for HRV alone. Bacterial infection was identified in 9.5%. Febrile infants with HRV detected were more likely to have bacterial infection than those with non-HRV viruses (7.8% vs 3.7%; P < .001; RR 2.12 [95% CI 1.43–3.15]). Risk of urinary tract infection was not significantly different for HRV-positive infants at any age, nor was risk of invasive bacterial infection (IBI; bacteremia and/or meningitis) meaningfully different for infants 1–28 day olds. Infants 29–90 days old with HRV had a decreased likelihood of IBI (RR 0.52 [95% CI 0.34–0.80]). CONCLUSIONS: HRV is common in febrile infants. Detection did not alter risk of concomitant urinary tract infection at any age or risk of IBI in infants 1–28 days old. HRV detection may be relevant in considering risk of IBI for infants 29–90 days of age.
Poly(butylene terephthalate) electrospun/melt‐blown composite mats for white blood cell filtration

In this research, poly(butylene terephthalate) (PBT) electrospun nanofibrous mats were prepared for white blood cell (WBC) filtration after the blood was collected from donors. The feasibility of using PBT electrospun mats used as WBC filtration materials was studied. The average fiber diameter and mean pore diameter of the PBT electrospun mats were much lower than those of melt-blown mats, and such properties were found to be beneficial for the functions of filtration and cell absorbency. A layer of PBT electrospun mats was added before the exit of filter; this formed a kind of compound material with different pore diameters and fibers diameters in the direction of blood flow. The WBC filtration efficiency of the newly designed filter and a traditional filter were also compared. The results show that filters with electrospun PBT fibers reduced the number of WBCs to 104/L, whereas the remaining WBCs after flow through the traditional filter was about 105L−1. The existence of electrospun fibers increased the filtration resistance at the same time, and this led to a longer filtration time. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013
A conceptual approach for the impact of the day of observation of image composites on time series generation

To eliminate atmospheric disturbances and sensor malfunctions many remote sensing products are offered in form of composites that combine multiple observations over a defined period. However, selecting specific observations result in varying interval lengths which affect and limit time series analysis techniques. This study provides a conceptual view on the possibilities to use or define specific composite days and its impact on time series. Often the starting or final day of the compositing period is selected, alternatively the middle day may be chosen. These time series are compared to a series that considers the actual day of observation. An experimental exercise employs 16-day MODIS VI composites of 1000m spatial resolution for a 1100×500km region in central Mexico. Statistical measures such as temporal cross-correlation, harmonic analysis, and difference in start, center, and end of season were used to characterize the temporal shift in time series. A shift of approximately seven days with a high variability is introduced when using the starting day of the compositing period, which is mitigated with assuming the middle day. However, only time series that take into account the day of observation can be used for correct estimation of temporal characteristics.
Prognostic value of troponin in infants with hypoplastic left heart syndrome between Stage I and II of palliation

Background : The period between stage I and II procedure for treatment of hypoplastic left heart syndrome (HLHS) bears high mortality and morbidity. Methods : We sought to analyze the prognostic value of Troponin T/I (Trop), a well-recognized marker for myocardial damage and heart failure, for predicting outcome in a retrospective analysis of 70 infants with HLHS at our institution between March 2001 and October 2014. Results : Stage I procedure consisted of Norwood I operation in 35 (50%) and Hybrid-approach in 22 (31%) patients. Palliative care was chosen for 13 (19%) patients. Trop values were collected from clinical charts and were analyzed in relation to the overall outcome. Trop was significantly higher after Norwood I operation in comparison to Hybrid-approach (median 7.1 g/l (0.7-20.9), vs 1.2 g/l (0.3-17.9), P < 0.001). Overall mortality of treated patients was 39% (22 patients). Survival was 54% (19 patients) after Norwood and 73% (16 patients) after Hybrid-approach. Independently from the procedure used, maximal Trop and initial lactate values were significantly higher in non-survivors than in survivors, with median Trop of 9 g/l (0.6-18.8) vs. 3.4 g/l (0.4-20.9), P 0.007, and median lactate of 3.7 mmol/L (1.6-25) vs. 2.9 mmol/L (0.3-14.6), p 0.03. Reinterventions were required in 17 (30%) patients, 4 (11%) after Norwood and 13 (59%) after Hybrid procedure. No correlation was found between the need for reintervention and Trop levels in the interstage period. Conclusions : Patients with HLHS have significantly higher Trop levels after Norwood procedure than after Hybrid-approach. Maximal Trop values were related to mortality, but did not correlate with the need for reinterventions.
The feasibility of using natural language processing to extract clinical information from breast pathology reports

Objective: The opportunity to integrate clinical decision support systems into clinical practice is limited due to the lack of structured, machine readable data in the current format of the electronic health record. Natural language processing has been designed to convert free text into machine readable data. The aim of the current study was to ascertain the feasibility of using natural language processing to extract clinical information from >76,000 breast pathology reports. Approach and Procedure: Breast pathology reports from three institutions were analyzed using natural language processing software (Clearforest, Waltham, MA) to extract information on a variety of pathologic diagnoses of interest. Data tables were created from the extracted information according to date of surgery, side of surgery, and medical record number. The variety of ways in which each diagnosis could be represented was recorded, as a means of demonstrating the complexity of machine interpretation of free text. Results: There was widespread variation in how pathologists reported common pathologic diagnoses. We report, for example, 124 ways of saying invasive ductal carcinoma and 95 ways of saying invasive lobular carcinoma. There were >4000 ways of saying invasive ductal carcinoma was not present. Natural language processor sensitivity and specificity were 99.1% and 96.5% when compared to expert human coders. Conclusion: We have demonstrated how a large body of free text medical information such as seen in breast pathology reports, can be converted to a machine readable format using natural language processing, and described the inherent complexities of the task.
THEORY OF THERMOLUMINESCENCE AND RELATED PHENOMENA

In this text, the authors offer an account of thermoluminescence (TL) and other thermally stimulated phenomena. Although most recent experimental results of TL in different materials are described in some detail, the emphasis is on general processes, and the approach is more theoretical.Thus , the details of the possible processes which can take place during the excitation of the sample, and during its heating, are analyzed. The methods for analyzing TL glow curves are critically discussed, and recommendations as to their application are made. Also discussed are the expected behaviour of these phenomena as functions of the experimental parameters, for example, the dose of excitation. The consequences concerning the main applications of TL (for example, radiation dosimetry) are also discussed in detail as well as the similarities and dissimilarities of other thermally stimulated phenomena, and the simultaneous measurements of the latter and TL.
Behavior of different suture materials in the urinary bladder of the rabbit with special reference to wound healing, epithelization and crystallization.

Five urinary bladder incisions were performed in 16 rabbits and the defects closed by plain catgut 4-0, chromic catgut 4-0, polypropylene 4-0, polyglactin 910 4-0 and polyglactin 910 8-0 in the form of an all-layer suture, thereby obtaining a total of 80 suture sites. The running sutures in 8 animals were reviewed by light microscopy after 1, 2, 7 and 15 weeks, and in 8 additional animals after 3 days, 1, 2, 7 and 15 weeks by scanning electron microscopy. Moreover, we analyzed and compared the autopsy findings on gross inspection, the urinary sediments and urinary cultures of the individual animals. Scanning electron-microscopic evaluations showed that epithelization of the intraluminal suture portions can be accomplished after 3 days already. Reduced suture strength and rapid absorption of the suture material prevent later postoperative incrustations. Light-microscopic inspection of the segments of the bladder wall bearing this suture material suggests that a minor inflammatory tissue response around the suture material--with polyglactin 910 8-0 in particular--is more likely to enhance regeneration of the tunica muscularis and to prevent formation of cysts than seen with a long-standing highly inflammatory tissue response around the suture site of catgut threads. In the animal experiment, the polyglactin 910 suture has shown sufficient firmness and proved to be superior to any other suture material as regards the reaction to foreign bodies and inclination to incrustation. (ABSTRACT TRUNCATED AT 250 WORDS)
Assessing Operator Wellbeing through Physiological Measurements in Real-Time—Towards Industrial Application

This article focuses on how operator wellbeing can be assessed to ensure social sustainability and operator performance at assembly stations. Rapid technological advances provide possibilities for assessing wellbeing in real-time, and from an assembly system perspective, this could enable the assessment of physiological data in real-time. While technology is available, it has not been implemented or tested in industry. The aim of this paper was to investigate empirically how concurrent physiological measurement technologies can be integrated into an industrial application, in order to increase operator wellbeing and operator performance. A mixed method approach was used, which included a literature study, two laboratory tests, two case studies and a workshop. The results indicated that operator wellbeing could be assessed through electro-dermal activity, but that the data is perceived as difficult to interpret. For an industrial application, operator perception and data presentation are important and risks connected to personal integrity and IT-support need to be addressed. Future work includes testing how a combination of physiological measures and self-assessments can be used to assess operator wellbeing in an industrial context.
Vision testing is additive to the sideline assessment of sports-related concussion

SummaryWe examined the King-Devick (K-D) test, a vision-based test of rapid number naming, as a complement to components of the Sport Concussion Assessment Tool, 3rd edition (SCAT3) for diagnosis of concussion. Baseline and postconcussion data for the University of Florida men's football, women's soccer, and women's lacrosse teams were collected, including the K-D test, Standardized Assessment of Concussion (SAC), and Balance Error Scoring System (BESS). Among 30 athletes with first concussion during their athletic season (n = 217 total), differences from baseline to postinjury showed worsening of K-D time scores in 79%, while SAC showed a ≥2-point worsening in 52%. Combining K-D and SAC captured abnormalities in 89%; adding the BESS identified 100% of concussions. Adding a vision-based test may enhance the detection of athletes with concussion.
Does a less intensive surveillance protocol affect the survival of patients after treatment of a sarcoma of the limb?: UPDATED RESULTS OF THE RANDOMIZED TOSS STUDY

Aims A single‐centre prospective randomized trial was conducted to investigate whether a less intensive follow‐up protocol would not be inferior to a conventional follow‐up protocol, in terms of overall survival, in patients who have undergone surgery for sarcoma of the limb. Initial short‐term results were published in 2014. Patients and Methods The primary objective was to show non‐inferiority of a chest radiograph (CXR) group compared with a CT scan group, and of a less frequent (six‐monthly) group than a more frequent (three‐monthly) group, in two‐by‐two comparison. The primary outcome was overall survival and the secondary outcome was a recurrence‐free survival. Five‐year survival was compared between the CXR and CT scan groups and between the threemonthly and six‐monthly groups. Of 500 patients who were enrolled, 476 were available for follow‐up. Survival analyses were performed on a per‐protocol basis (n = 412). Results The updated results recorded 12 (2.4%) local recurrences, 182 (36.8%) metastases, and 56 (11.3%) combined (local + metastases) recurrence at a median follow‐up of 81 months (60 to 118). Of 68 local recurrences, 60 (88%) were identified by the patients themselves. The sixmonthly regime (overall survival (OS) 54%, recurrence‐free survival (RFS) 46%) did not lead to a worse survival and was not inferior to the three‐monthly regime (OS 55%, RFS 47%) in terms of detecting recurrence. Although CT scans (OS 53%, RFS 54%) detected pulmonary metastasis earlier, it did not lead to a better survival compared with CXR (OS 56%, RFS 59%). Conclusion The overall survival of patients who are treated for a sarcoma of the limb is not inferior to those followed up with a less intensive regimen than a more intensive protocol, in terms of frequency of visits and mode of imaging. CXR at six‐monthly intervals and patient education about examination of the site of the surgery will detect most recurrences without deleterious effects on the eventual outcome.
Medicinal Plants from Near East for Cancer Therapy

Background: Cancer is one of the major problems affecting public health worldwide. As other cultures, the populations of the Near East rely on medicinal herbs and their preparations to fight cancer. Methods: We compiled data derived from historical ethnopharmacological information as well as in vitro and in vivo results and clinical findings extracted from different literature databases including (PubMed, Scopus, Web of Science, and Google Scholar) during the past two decades. Results: In this survey, we analyzed the huge amount of data available on anticancer ethnopharmacological sources used in the Near East. Medicinal herbs are the most dominant ethnopharmacological formula used among cancer’s patients in the Near East. The data obtained highlight for the first time the most commonly used medicinal plants in the Near East area for cancer treatment illustrating their importance as natural anticancer agents. The literature survey reveals that various Arum species, various Artemisia species, Calotropis procera, Citrullus colocynthis, Nigella sativa, Pulicaria crispa, various Urtica species, Withania somnifera, and others belong to the most frequently used plants among cancer patients in the Near East countries. Molecular modes of action that have been investigated for plant extracts and isolated compounds from Near East include cell cycle arrest and apoptosis induction with participation of major player in these processes such as p53 and p21, Bcl-2, Bax, cytochrome c release, poly (ADP-ribose) polymerase cleavage, activation of caspases, etc. Conclusion: The ethnopharmacology of the Near East was influenced by Arabic and Islamic medicine and might be promising for developing new natural and safe anticancer agents. Further research is required to elucidate their cellular and molecular mechanisms and to estimate their clinical activity.
To boost or to CRUNCH? Effect of effortful encoding on episodic memory in older adults is dependent on executive functioning

It is essential to develop effective interventions aimed at ameliorating age-related cognitive decline. Previous studies found that effortful encoding benefits episodic memory in older adults. However, to date it is unclear whether this benefit is different for individuals with strong versus weak executive functioning (EF). Fifty-one older adults were recruited and divided into low (N = 26) and high (N = 25) functioning groups, based on their EF capacity. All participants performed a semantic and a perceptual incidental encoding task. Each encoding task was performed under four difficulty levels to establish different effort levels. Encoding was followed by a recognition task. Results showed that the high EF group benefitted from increased effort in both tasks. However, the low EF group only showed a beneficial effect under low levels of effort. Results are consistent with the Compensation-Related Utilization of Neural Circuits Hypothesis (CRUNCH) and suggest that future research directed at developing efficient memory strategies to reduce negative cognitive aging effects should take individual cognitive differences among older adults into account, such as differences in EF.
Detailed Investigation of the Electric Discharge Plasma between Copper Electrodes Immersed into Water

A phenomenological picture of pulsed electrical discharge in water is produced by combining electrical, spectroscopic, and imaging methods. The discharge is generated by applying ~350 μs long 100 to 220 V pulses (values of current from 400 to 1000 A, respectively) between the point-to-point copper electrodes submerged into the non-purified tap water. Plasma channel and gas bubble occur between the tips of the electrodes, which are initially in contact with each other. The study includes detailed experimental investigation of plasma parameters of such discharge using the correlation between time-resolved high-speed imaging, electrical characteristics, and optical emission spectroscopic data. Radial distributions of the electron density of plasma is estimated from the analysis of profiles and widths of registered Hα and Hβ hydrogen lines, and Cu I 515.3 nm line, exposed to the Stark mechanism of spectral lines’ broadening. Estimations of the electrodes’ erosion rate and bubbles’ size depending on the electrical input parameters of the circuit are presented. Experimental results of this work may be valuable for the advancement of modeling and the theoretical understanding of the pulse electric discharges in water.
Time Series Momentum

We document significant ‘‘time series momentum’’ in equity index, currency, commodity, and bond futures for each of the 58 liquid instruments we consider. We find persistence in returns for one to 12 months that partially reverses over longer horizons, consistent with sentiment theories of initial under-reaction and delayed over-reaction. A diversified portfolio of time series momentum strategies across all asset classes delivers substantial abnormal returns with little exposure to standard asset pricing factors and performs best during extreme markets. Examining the trading activities of speculators and hedgers, we find that speculators profit from time series momentum at the expense of hedgers.
Evolution of Phototrophy in the Chloroflexi Phylum Driven by Horizontal Gene Transfer

The evolutionary mechanisms behind the extant distribution of photosynthesis is a point of substantial contention. Hypotheses range from the presence of phototrophy in the last universal common ancestor and massive gene loss in most lineages, to a later origin in Cyanobacteria followed by extensive horizontal gene transfer into the extant phototrophic clades, with intermediate scenarios that incorporate aspects of both end-members. Here, we report draft genomes of 11 Chloroflexi: the phototrophic Chloroflexia isolate Kouleothrix aurantiaca as well as 10 genome bins recovered from metagenomic sequencing of microbial mats found in Japanese hot springs. Two of these metagenome bins encode photrophic reaction centers and several of these bins form a metabolically diverse, monophyletic clade sister to the Anaerolineae class that we term Candidatus Thermofonsia. Comparisons of organismal (based on conserved ribosomal) and phototrophy (reaction center and bacteriochlorophyll synthesis) protein phylogenies throughout the Chloroflexi demonstrate that two new lineages acquired phototrophy independently via horizontal gene transfer (HGT) from different ancestral donors within the classically phototrophic Chloroflexia class. These results illustrate a complex history of phototrophy within this group, with metabolic innovation tied to HGT. These observations do not support simple hypotheses for the evolution of photosynthesis that require massive character loss from many clades; rather, HGT appears to be the defining mechanic for the distribution of phototrophy in many of the extant clades in which it appears.
Methylation Profiling of Urothelial Carcinoma in Bladder Biopsy and Urine

OBJECTIVE To test DNA methylation profiling in detection of urothelial carcinoma in urine. STUDY DESIGN Thirty-three bladder specimens were analyzed for the DNA p16INK4a, RASSF1, APC, GSTP, E-Cad and CyclinD2 genes to determine if there is a difference in gene methylation between benign and malignant cases. Urine samples were analyzed in a feasibility study. Finally, methylation profiles of urine samples were obtained and compared with follow-up biopsy diagnoses. RESULTS We found methylated genes in 18% benign, 37% urothelial carcinoma in situ and 93% infiltrating urothelial carcinoma cases (p = 0.001). Methylation profiles from the 18 urine samples revealed a significantly higher prevalence of methylated genes in carcinoma cases than benign cases (100% vs. 50%, p = 0.025). We analyzed methylation profiles in 37 cytologically atypical urine samples with malignant or benign diagnosis on surgical follow-up andfound that only APC (55% in malignant vs. 0% in benign, p=0.025) and CyclinD2 were differentially methylated (35% in malignant vs. 0% in benign, p=0.2) while p14ARF, p16INK4a, RASSF1, GSTP and E-Cad had similar methylation profiles. CONCLUSION These results suggest that methylation of p14ARF, p16INK4a, RASSF1, GSTP and E-Cad genes may not accurately identify carcinoma, but methylated APC and CyclinD2 might be useful biomarkers for urothelial carcinoma in urine.