Miracle-dz/UniFAR-FTUs huggingface dataset:
Rapid evolution of flowering time by an annual plant in response to a climate fluctuation

Ongoing climate change has affected the ecological dynamics of many species and is expected to impose natural selection on ecologically important traits. Droughts and other anticipated changes in precipitation may be particularly potent selective factors, especially in arid regions. Here we demonstrate the evolutionary response of an annual plant, Brassica rapa, to a recent climate fluctuation resulting in a multiyear drought. Ancestral (predrought) genotypes were recovered from stored seed and raised under a set of common environments with descendant (postdrought) genotypes and with ancestor×descendant hybrids. As predicted, the abbreviated growing seasons caused by drought led to the evolution of earlier onset of flowering. Descendants bloomed earlier than ancestors, advancing first flowering by 1.9 days in one study population and 8.6 days in another. The intermediate flowering time of ancestor×descendant hybrids supports an additive genetic basis for divergence. Experiments confirmed that summer drought selected for early flowering, that flowering time was heritable, and that selection intensities in the field were more than sufficient to account for the observed evolutionary change. Natural selection for drought escape thus appears to have caused adaptive evolution in just a few generations. A systematic effort to collect and store propagules from suitable species would provide biologists with materials to detect and elucidate the genetic basis of further evolutionary shifts driven by climate change.
Performance and Return to Sport After Anterior Cruciate Ligament Reconstruction in Male Major League Soccer Players

Background: Anterior cruciate ligament (ACL) rupture is a significant injury in male Major League Soccer (MLS) players in the United States. Purpose: To determine (1) return-to-sport (RTS) rate in MLS following ACL reconstruction (ACLR), (2) timing of RTS, (3) performance upon RTS, and (4) the difference in RTS and performance between players who underwent ACL reconstruction (ACLR) and controls. Study Design: Case-control study; Level of evidence, 3. Methods: MLS players undergoing ACLR between 1996 and 2012 were evaluated. Player data were extracted from publically available sources. All demographic data were analyzed. A control group of players matched by age, body mass index (BMI), sex, position, performance, and MLS experience (occurred at 2.6 years into career, designated “index year”) was selected from the MLS during the same years as those undergoing ACLR. The RTS and performance in the MLS were analyzed and compared between cases and controls. Student ttests were performed for analysis of within- and between-group variables. Results: A total of 52 players (57 knees) that met inclusion criteria underwent ACLR while in the MLS. Mean player age was 25.6 ± 3.98 years. Forty players were able to resume play (77%). Of the 40 players (45 knees), 38 (43 knees; 95%) resumed play the season following ACLR (mean, 10 ± 2.8 months after surgery). Mean career length in the MLS after ACLR was 4.0 ± 2.8 years. The revision rate was 10%. There was a significant increase in the incidence of ACL tears in the MLS by year (P < .001), and there was a significantly (P= .002) greater number of ACL tears on the left knee as opposed to the right. Performance in the MLS upon RTS after ACLR was not significantly different versus preinjury. There was no significant difference in survival in the MLS between cases and controls after ACLR or index year. The only significant performance differences between cases and controls were that cases had significantly greater shots taken per season (P= .005) and assists (P= .005) than did controls after the index year. Conclusion: There is a high RTS rate in the MLS following ACLR. Nearly all players resumed play the season after surgery. Performance was not significantly different from preinjury. Only 2 performance measures (shots taken and assists) were significantly different between cases and controls. A significantly greater number of ACL tears occur in the left versus the right knee.
Relative Price Levels and Current Accounts: An Exploration

This paper studies the links between current accounts and relative price levels, finding that current account changes are associated with sizable future relative price levels effects. This is done in panel regressions of the Penn effect, adding a lagged current account/GDP and other explanatory variables. Higher GDP/capita and a greater export share of manufacturing tend to mitigate the real exchange rate impact of lagged current accounts. Active management of current accounts may provide a powerful adjustment channel, mitigating the real exchange rate effects of volatile terms of trade, and may explain the growing proliferation of Sovereign Wealth Funds.
The Wiley-Blackwell handbook of legal and ethical aspects of sex offender treatment and management

The Wiley-Blackwell Handbook of Legal and Ethical Aspects of Sex Offender Treatment and Management is edited by Dr. Bernadette Rainey (Cardiff Law School) and Dr. Karen Harrison (University of Hull). This vital new work is the first of its kind and fills a gap in the academic literature. It assembles a broad spectrum of research from numerous national jurisdictions, reflecting the rising international profile of the subject among academics and policy makers. As well as covering a range of legal and ethical concerns such as human rights and sentencing policy, the volume features dedicated material from leading academics and practitioners on the legal and ethical issues in sex offender treatment and risk management. This new publication combines the latest theory with a wealth of international perspectives on a high-profile, and highly complex, subject.
Posttraumatic stress disorder in children

Posttraumatic stress disorder is a mental disorder after exposure to severe traumatic or stressful event. In children the common causes are abused, trauma, disaster, terrorism, and critical illness. The clinical sign and symptom, one-month-aftermath, are re-experiencing, avoidant, negative in cognition and arousal. Trauma-focused cognitive behavior therapy is the treatment of choice. This report was presented the two cases of PTSD, young child and adolescent girl, exposed to severe trauma and developed PTSD. โรคความผดปกตทางจตใจภายหลงภยนตรายในเดก โรคความผดปกตทางจตใจภายหลงภยนตรายในเดก เปนความผดปกตทางจตใจภายหลงประสบกบภยนตราย ทรนแรง ในเดกมกพบโรคนตามหลงการถกทารณกรรม อบตภย วนาศภย การกอการราย หรอแมกระทงภาวะเฉยดตาย จากการเจบปวย อาการแสดงของโรค ภายหลง 1 เดอน จากเหตการณคอ ยงนกกลวถงเหตการณ หลกเลยงทจะเผชญ มการเปลยนแปลงทางอารมณตระหนกกลว การรกษาไดผลดดวยการทำจตพฤตกรรมบำบดมงประเดนทเกดจากภยนตราย รายงานนนำเสนอผปวยเดกเลก1รายและวยรน 1 ราย ทผานเหตการณรนแรงมาเกน 1เดอน และยงมอาการทางจตใจอย
HOTAIR Promotes Proliferation, Migration, and Invasion of Ovarian Cancer SKOV3 Cells Through Regulating PIK3R3

Background The aim of this study was to determine the effect on proliferation, migration, and invasion after silencing HOTAIR in ovarian cancer SKOV3 cells, and to elucidate the potential mechanism. Material/Methods We analyzed the mRNA expression level of HOTAIR and PIK3R3 in ovarian cancer SKOV3, OVCAR3, and A2780 cell lines. We analyzed the mRNA expression level of HOTAIR and PIK3R3 in ovarian SKOV3 after transection with miR-214 or miR-217. We analyzed the mRNA and protein expression level of PIK3R3 when silencing HOTAIR. We analyzed the expression of HOTAIR when silencing PIK3R3. We analyzed the proliferation, migration and invasion in ovarian cancer SKOV3 after silencing HOTAIR or PIK3R3. Results The expression of HOTAIR and PIK3R3 in ovarian SKOV3 and OVCAR3 was increased compared with A2780 cells (P<0.05). The mRNA level of HOTAIR and PIK3R3 in ovarian cancer SKOV3 cells was decreased when transected with miR-214 or miR-217 compared to negative control (p<0.05). The mRNA and protein level of PIK3R3 was decreased when HOTAIR was silenced and the mRNA level of HOTAIR was decreased when PIK3R3 was silenced (p<0.05). The proliferation, migration and invasion was decreased in ovarian SKOV3 when HOTAIR or PIK3R3 was silenced (p<0.05). Conclusions HOTAIR can promote proliferation, migration, and invasion in ovarian SKOV3 cells as a competing endogenous RNA.
Image Outlier Detection and Feature Extraction via L1-Norm-Based 2D Probabilistic PCA

This paper introduces an L1-norm-based probabilistic principal component analysis model on 2D data (L1-2DPPCA) based on the assumption of the Laplacian noise model. The Laplacian or L1 density function can be expressed as a superposition of an infinite number of Gaussian distributions. Under this expression, a Bayesian inference can be established based on the variational expectation maximization approach. All the key parameters in the probabilistic model can be learned by the proposed variational algorithm. It has experimentally been demonstrated that the newly introduced hidden variables in the superposition can serve as an effective indicator for data outliers. Experiments on some publicly available databases show that the performance of L1-2DPPCA has largely been improved after identifying and removing sample outliers, resulting in more accurate image reconstruction than the existing PCA-based methods. The performance of feature extraction of the proposed method generally outperforms other existing algorithms in terms of reconstruction errors and classification accuracy.
Newspaper commentaries on terrorism in China and Australia: A contrastive genre study

Newspaper articles are a common genre that has been examined in contrastive rhetoric research to explore its rhetorical and linguistic patterns. However, this chapter aims to go beyond this and to explore how the writers position themselves, manipulate the topic and address their readers by the use of various linguistic strategies and devices. This chapter illustrates the key findings by examining two newspaper commentaries, one Chinese and one Australian. The analysis indicates that the Chinese writer tends to avoid personal voice by the use of more facts and evidence to establish arguments, while the Australian writer shows personal identity clearly by presenting his viewpoint. These findings are discussed in relation to the respective sociocultural contexts in which the texts were written.
Diazepam-induced changes in sleep: Role of the α1 GABAA receptor subtype

Ligands acting at the benzodiazepine (BZ) site of γ-aminobutyric acid type A (GABAA) receptors currently are the most widely used hypnotics. BZs such as diazepam (Dz) potentiate GABAA receptor activation. To determine the GABAA receptor subtypes that mediate the hypnotic action of Dz wild-type mice and mice that harbor Dz-insensitive α1 GABAA receptors [α1 (H101R) mice] were compared. Sleep latency and the amount of sleep after Dz treatment were not affected by the point mutation. An initial reduction of rapid eye movement (REM) sleep also occurred equally in both genotypes. Furthermore, the Dz-induced changes in the sleep and waking electroencephalogram (EEG) spectra, the increase in power density above 21 Hz in non-REM sleep and waking, and the suppression of slow-wave activity (SWA; EEG power in the 0.75- to 4.0-Hz band) in non-REM sleep were present in both genotypes. Surprisingly, these effects were even more pronounced in α1(H101R) mice and sleep continuity was enhanced by Dz only in the mutants. Interestingly, Dz did not affect the initial surge of SWA at the transitions to sleep, indicating that the SWA-generating mechanisms are not impaired by the BZ. We conclude that the REM sleep inhibiting action of Dz and its effect on the EEG spectra in sleep and waking are mediated by GABAA receptors other than α1, i.e., α2, α3, or α5 GABAA receptors. Because α1 GABAA receptors mediate the sedative action of Dz, our results provide evidence that the hypnotic effect of Dz and its EEG “fingerprint” can be dissociated from its sedative action.
Apoptosis Induced by a New Member of Saponin Family Is Mediated through Caspase-8-Dependent Cleavage of Bcl-2

OSW-1 is a new member of cholestane saponin family, which is cytotoxic against several types of malignant cells. We reported herein that OSW-1 induced apoptosis of mammalian cells in a concentration- and time-dependent manner. The drug-induced apoptosis was mediated through the mitochondrial pathway, involving the cleavage of Bcl-2. This drug-induced Bcl-2 cleavage in Chinese hamster ovary (CHO) cells could be suppressed either by dominant-negative caspase-8 or by a caspase-8 inhibitor, suggesting that the Bcl-2 cleavage is dependent on caspase-8. In contrast, the Bcl-2 cleavage was independent of caspase-3 activity. The inhibition of caspase-8 activity also resulted in the reduction of apoptotic cells, indicating that Bcl-2 cleavage induced by caspase-8 promotes the progression of apoptosis. The involvement of the caspase-8 activity in the processes of the OSW-1-induced apoptosis was further examined by using caspase-8-deficient Jurkat T cells. It was found that the caspase-8-deficient cells were resistant to OSW-1-induced Bcl-2 cleavage or apoptosis. Furthermore, the small subunit of caspase-8 was found to interact with Bcl-2 as determined by yeast two-hybrid and coimmunoprecipitation assays. Overexpression of caspase-8 small subunit reduced the cleavage of Bcl-2 and inhibited the apoptosis induced by OSW-1. Taken together, these results demonstrate that OSW-1 is capable of inducing apoptosis in mammalian cells, in which the caspase-8-dependent cleavage of Bcl-2 plays an important role.
Brabykinin B1 Receptor Antagonism Is Beneficial in Renal Ischemia-Reperfusion Injury

Previously we have demonstrated that bradykinin B1 receptor deficient mice (B1KO) were protected against renal ischemia and reperfusion injury (IRI). Here, we aimed to analyze the effect of B1 antagonism on renal IRI and to study whether B1R knockout or antagonism could modulate the renal expression of pro and anti-inflammatory molecules. To this end, mice were subjected to 45 minutes ischemia and reperfused at 4, 24, 48 and 120 hours. Wild-type mice were treated intra-peritoneally with antagonists of either B1 (R-954, 200 µg/kg) or B2 receptor (HOE140, 200 µg/kg) 30 minutes prior to ischemia. Blood samples were collected to ascertain serum creatinine level, and kidneys were harvested for gene transcript analyses by real-time PCR. Herein, B1R antagonism (R-954) was able to decrease serum creatinine levels, whereas B2R antagonism had no effect. The protection seen under B1R deletion or antagonism was associated with an increased expression of GATA-3, IL-4 and IL-10 and a decreased T-bet and IL-1β transcription. Moreover, treatment with R-954 resulted in lower MCP-1, and higher HO-1 expression. Our results demonstrated that bradykinin B1R antagonism is beneficial in renal IRI.
On-Line Control of Discrete Event Systems with a Maximally Controllable and Observable Sublanguage

Recently, many on-line control methods of partially observed discrete event systems(DES’s) have been proposed. This paper proposes an algorithm for on-line control based on a supervisor under complete observation. It is shown that DES’s controlled by the proposed on-line controller generate maximally controllable and observable sublanguages which include the supremal normal sublanguages. Moreover, computational complexity of the proposed algorithm is polynomial with respect to the numbers of the unobservable events and the state of the supervisor under complete observation. key words: discrete event system, supervisory control, partial observation, on-line control
Environmental and performance management forces: Integrating “greenness” into balanced scorecard

Purpose – The purpose of this paper is to analyze the forces that prompted a Finnish food manufacturing company to implement environmental management system (EMS) and performance management system (PMS). The paper also aims to describe how and why environmental issues were integrated onto a balanced scorecard (BSC). Design/methodology/approach – The paper utilizes both qualitative and longitudinal case study approaches. Semi‐structured interviews are the main source of empirical data; these were conducted by both researchers.Findings – The forces driving the implementation of the EMS changed from external to internal forces over time. The initial purpose of EMS implementation was to obtain an environmental certificate. Later on the forces turned to internal ones when the causal link between improving environmental performance and profitability was recognized. The PMS implementation, as well as the PMS and EMS integration, had internal forces driving them. The company integrated environmental indicators int.
Primary care Randomised controlled trial of home based care of patients with chronic obstructive pulmonary disease

Objectives To evaluate usefulness of limited community based care for patients with chronic obstructive pulmonary disease after discharge from hospital. Design Randomised controlled trial. Setting Liverpool Health Service and Macarthur Health Service in outer metropolitan Sydney between September 1999 and July 2000. Participants 177 patients randomised into an intervention group (84 patients) and a control group (93 patients) which received current usual care. Interventions Home visits by community nurse at one and four weeks after discharge and preventive general practitioner care. Main outcome measures Frequency of patients’ presentation and admission to hospital; changes in patients’ disease-specific quality of life, measured with St George’s respiratory questionnaire, over three months after discharge; patients’ knowledge of illness, self management, and satisfaction with care at discharge and three months later; frequency of general practitioner and nurse visits and their satisfaction with care. Results Intervention and control groups showed no differences in presentation or admission to hospital or in overall functional status. However, the intervention group improved their activity scores and the control group worsened their symptom scores. While intervention group patients received more visits from community nurses and were more satisfied with their care, involvement of general practitioners was much less (with only 31% (22) remembering receiving a care plan). Patients in the intervention group had higher knowledge scores and were more satisfied. There were no differences in general practitioner visits or management. Conclusions This brief intervention after acute care improved patients’ knowledge and some aspects of quality of life. However, it failed to prevent presentation and readmission to hospital.
Fecal S100A12 in Healthy Infants and Children

Background and Aims. Fecal S100A12 is shown to be a useful noninvasive marker of gut inflammation. However, the studies to date have not characterised the patterns of expression in healthy young children. This study aimed to determine S100A12 levels in infants and children without symptoms of underlying gut disease. Methods. Stool samples were collected from healthy infants (<12 months) and children without gastrointestinal symptoms. Faecal S100A12 was measured by immunoassay. Results. Fifty-six children were recruited. Serial samples were obtained from seven term infants over the first 6 months of life. Single samples were obtained from 49 healthy children ranging from 0.16 to 13.8 years of age. Median S100A12 levels were 0.5 mg/kg (ranging from 0.39 to 25) in the healthy children, with high values (>10 mg/kg) in five infants only. There was no variation between gender. Median S100A12 levels in healthy infants remained below the established normal cut-off from birth to six months of age. Conclusion. S100A12 levels in well infants and children are almost exclusively lower than the standard cut-off. Transiently higher levels may be seen in early infancy. An elevated level of S100A12 in children older than 12 months of age is likely to represent organic gut disease.
Low-Frequency Variability of the Yellow Sea Cold Water Mass Identified from the China Coastal Waters and Adjacent Seas Reanalysis

This study uses the China Coastal Waters and Adjacent Seas Reanalysis (CORA) data to investigate the interannual and decadal variability of the Yellow Sea cold water mass (YSCWM) and its relationship to climate indices including the Arctic Oscillation (AO), El Nino/Southern Oscillation (ENSO), and Pacific Decadal Oscillation (PDO). On the interannual timescale, the strong correlation between winter PDO and the YSCWM may indicate the dominant effect of winter PDO on the YSCWM through the modulation of local heat flux and wind stress. It is also found that the local wind stress and heat flux in summer have little impact on the interannual variability of the YSCWM. On the decadal time scale, the YSCWM is associated with winter AO and winter PDO. Winter AO mainly controls local heat flux, modulating the decadal variability of the YSCWM. In contrast, winter PDO is strongly connected with winter heat flux and wind stress to modulate the decadal variability of the YSCWM. In summer, for three climate factors, ENSO is the dominant factor controlling the decadal variability of the YSCWM.
Moisture Migration in an Oil-Paper Insulation System in Relation to Online Partial Discharge Monitoring of Power Transformers

Most power transformers operating in a power system possess oil-paper insulation. A serious defect of this type of insulation, which is associated with long operation time, is an increase in the moisture content. Moisture introduces a number of threats to proper operation of the transformer, e.g., ignition of partial discharges (PDs). Due to the varying temperature of the insulation system during the unit’s normal operation, a dynamic change (migration of water) takes place, precipitating the oil-paper system from a state of hydrodynamic equilibrium. This causes the PDs to be variable in time, and they may intensify or extinguish. Studies on model objects have been conducted to determine the conditions (temperature, humidity, time) that will have an impact on the ignition and intensity of the observed phenomenon of PDs. The conclusions of this study will have a practical application in the evaluation of measurements conducted in the field, especially in relation to the registration of an online PD monitoring system.
On the complexity of $\mathbb H$-coloring for special oriented trees

For a fixed digraph $\mathbb H$, the $\mathbb H$-coloring problem is the problem of deciding whether a given input digraph $\mathbb G$ admits a homomorphism to $\mathbb H$. The CSP dichotomy conjecture of Feder and Vardi is equivalent to proving that, for any $\mathbb H$, the $\mathbb H$-coloring problem is in in P or NP-complete. We confirm this dichotomy for a certain class of oriented trees, which we call special trees (generalizing earlier results on special triads and polyads). Moreover, we prove that every tractable special oriented tree has bounded width, i.e., the corresponding $\mathbb H$-coloring problem is solvable by local consistency checking. Our proof relies on recent algebraic tools, namely characterization of congruence meet-semidistributivity via pointing operations and absorption theory.