Miracle-dz/UniFAR-FTUs huggingface dataset:
Shared and Differential Retinal Responses against Optic Nerve Injury and Ocular Hypertension

Glaucoma, one of the leading causes of blindness worldwide, affects primarily retinal ganglion cells (RGCs) and their axons. The pathophysiology of glaucoma is not fully understood, but it is currently believed that damage to RGC axons at the optic nerve head plays a major role. Rodent models to study glaucoma include those that mimic either ocular hypertension or optic nerve injury. Here we review the anatomical loss of the general population of RGCs (that express Brn3a; Brn3a+RGCs) and of the intrinsically photosensitive RGCs (that express melanopsin; m+RGCs) after chronic (LP-OHT) or acute (A-OHT) ocular hypertension and after complete intraorbital optic nerve transection (ONT) or crush (ONC). Our studies show that all of these insults trigger RGC death. Compared to Brn3a+RGCs, m+RGCs are more resilient to ONT, ONC, and A-OHT but not to LP-OHT. There are differences in the course of RGC loss both between these RGC types and among injuries. An important difference between the damage caused by ocular hypertension or optic nerve injury appears in the outer retina. Both axotomy and LP-OHT induce selective loss of RGCs but LP-OHT also induces a protracted loss of cone photoreceptors. This review outlines our current understanding of the anatomical changes occurring in rodent models of glaucoma and discusses the advantages of each one and their translational value.
Continuous Multiparametric Monitoring of Brain Activities Following Fluid-Percussion Injury in Rats: Preliminary Results

Severe head injury can result in a high mortality rate or irreversible brain damage. One technique used to induce traumatic brain injury (TBI) is exposure of the brain to fluid percussion pressure while monitoring the increase in intracranial pressure (ICP). Since brain injury is a multifactorial, pathological, time-dependent state, the multiparametric monitoring approach was adopted for studying fluid percussion effects on the rat brain. A multiprobe assembly (MPA) connected to the brain in vivo (right hemisphere) enabled the simultaneous monitoring of CBF, NADH redox state, extracellular K+, Ca2+, H+ levels as well as DC potential, ECoG and ICP. The animal was connected to the monitoring system and exposed to TBI after a recuperation period of at least 3 hours after the end of the operation. Two typical responses to TBI were recorded in our preliminary experiments. When severe injury was induced, ischemic depolarization (ID) developed, whereas mild or moderate injury led to repetitive spreading depression (SD) cycles. The relationship between the ID and SD observed under TBI is important to the understanding of the mechanism of brain injury. ICP before injury was between 2-6 mm Hg and increased to 20-22 mm Hg 2-3 minutes after the ID. After severe head injury, ICP remained high and in some cases increased to critical values causing death of these animals. Some animals developed seizures at various stages after the TBI. Hyperbaric oxygenation was used as a therapeutic tool to treat severely injured animals. These preliminary results suggest that it is feasible and practical to use the MPA approach for monitoring the brain after TBI.
Homelessness and CKD: a cohort study.

BACKGROUND AND OBJECTIVES This study examined the associations between homelessness and clinical outcomes of CKD among adults from the urban healthcare safety net. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS This retrospective cohort study examined 15,343 adults with CKD stages 3-5 who received ambulatory care during 1996-2005 from the Community Health Network of San Francisco. Main outcome measures were time to ESRD or death and frequency of emergency department visits and hospitalizations. RESULTS Overall, 858 persons (6%) with CKD stages 3-5 were homeless. Homeless adults were younger, were disproportionately male and uninsured, and suffered from far higher rates of depression and substance abuse compared with adults with stable housing (P<0.001 for all comparisons). Over a median follow-up of 2.8 years (interquartile range=1.4-6.1), homeless adults experienced significantly higher crude risk of ESRD or death (hazard ratio=1.82, 95% confidence interval=1.49-2.22) compared with housed adults. This elevated risk was attenuated but remained significantly higher (adjusted hazard ratio=1.28, 95% confidence interval=1.04-1.58) after controlling for differences in sociodemographics, comorbid conditions, and laboratory variables. Homeless adults were also far more likely to use acute care services (median [interquartile range] number of emergency department visits was 9 [4-20] versus 1 [0-4], P<0.001) than housed counterparts. CONCLUSIONS Homeless adults with CKD suffer from increased morbidity and mortality and use costly acute care services far more frequently than peers who are stably housed. These findings warrant additional inquiry into the unmet health needs of the homeless with CKD to provide appropriate and effective care to this disadvantaged group.
Job satisfaction and performance of coaches of the spare-time sports schools in China.

Twelve organizational variables that were associated with the organizational effectiveness of spare-time sports schools in China were examined. Specifically, coaches' expressed satisfaction with their jobs and their performance was assessed, and the significant organizational correlates of these two effectiveness indicators were identified. Six hundred forty coaches participated in the study, Stepwise multiple regression analyses were carried out to determine if there were common determinants of coaches' job satisfaction and performance, The results showed that job influence, job motivation, incentive system, and leader behavior had a more pervasive influence on job satisfaction and job performance of the coaches than did other variables.
Statistical Analysis of the Current-Sharing Temperature Evolution in $\hbox{Nb}_{3}\hbox{Sn}$  Cable-in- Conduit-Conductors for ITER

During the test of ITER conductors at nominal conditions, a degradation of the current sharing temperature has been observed after electromagnetic cyclic loading. Rather than focusing on the microscopic phenomena at the origin of the degradation, the degradation process has been studied from a statistical point of view, analysing the whole dataset of ITER conductors: average degradations have been calculated after various cycle numbers. Possible correlation with the strand critical current has also been analysed. In order to model the evolution of has been correlated with the reliability against cracks formation; the reliability is in turn defined according to a two parameters Weibull distribution. The validity of this approach has been tested with the so-called “Weibull plot”. The Weibull exponents were calculated for several ITER conductors and were found to be lower than one, indicating that the failure rate, which may be regarded as the formation rate of fractures in the filaments composing the strands, is decreasing with the number of cycles.
Drug-related problems in community-dwelling primary care patients screened positive for dementia

ABSTRACT Background: Older people have a higher risk of drug-related problems (DRPs). However, little is known about the prevalence of DRPs in community-dwelling people who screened positive for dementia. Our study aimed to determine (1) the prevalence and types of DRPs and (2) the socio-demographic and clinical variables associated with DRPs in people screened positive for dementia in primary care. Methods: The Dementia: life- and person-centered help in Mecklenburg-Western Pomerania (DelpHi-MV) study is a general practitioner (GP)-based cluster-randomized controlled intervention study to implement and evaluate an innovative concept of collaborative dementia care management in the primary care setting in Germany. Medication reviews of 446 study participants were conducted by pharmacists based on a comprehensive baseline assessment that included a computer-based home medication assessment. ClinicalTrials.gov Identifier: NCT01401582. Results: A total of 1,077 DRPs were documented. In 414 study participants (93%), at least one DRP was detected by a pharmacist. The most frequent DRPs were administration and compliance problems (60%), drug interactions (17%), and problems with inappropriate drug choice (15%). The number of DRPs was significantly associated with the total number of drugs taken and with a formal diagnosis of a mental or behavioral disorder. Conclusions: Degree of cognitive impairment (MMSE defined) and formal diagnosis of dementia were not risk factors for an increased number of DRPs. However, the total number of drug taken and the presence of a diagnosis of mental and behavioral disorders were associated with an increased total number of DRPs.
Cooperative packet caching and shortest multipath routing in mobile ad hoc networks

A mobile ad hoc network is an autonomous system of infrastructureless, multihop wireless mobile nodes. Reactive routing protocols perform well in such an environment due to their ability to cope quickly against topological changes. In this paper, we propose a new routing protocol called Caching and Multipath (CHAMP) Routing Protocol. CHAMP uses cooperative packet caching and shortest multipath routing to reduce packet loss due to frequent route breakdowns. Simulation results reveal that by using a five-packet data cache, CHAMP exhibits excellent improvement in packet delivery, outperforming AODV and DSR by at most 30% in stressful scenarios. Furthermore, end-to-end delay is significantly reduced while routing overhead is lower at high mobility rates.
Combined Morphine-Bupivacaine Caudals for Reconstructive Penile Surgery in Children: Systemic Absorption of Morphine and Postoperative Analgesia

We wished to determine if the addition of a small dose of morphine (0.05 mg.kg−1) to a caudal solution of 0.25% bupivacaine could extend the duration of analgesia after major reconstructive penile surgery and also to measure the systemic absorption of morphine after caudal injection. Thirty children undergoing reconstructive penile surgery received a caudal injection of 0.25% bupivacaine 0.75 ml.kg−1 with or without morphine 0.05 mg.kg−1. All patients awoke pain-free, but eight of the fifteen patients receiving bupivacaine alone required supplementary injections of opioid postoperatively, whereas none of the patients receiving the bupivacaine-morphine mixture required additional opioids. The incidence of side-effects was similar for the two groups. Morphine was absorbed rapidly after caudal injection to reach a peak plasma level of 21.2 (±4.8) ng.ml−1 at ten minutes and then fell to 10.1 (±3.8) ng.ml−1 at one hour and 4.1 (±2.6) ng.mh−1 at three hours. These levels are low compared with plasma levels associated with systemic analgesia. We conclude that the extended duration of analgesia from morphine 0.05 mg/kg given caudally is due at least in part to specific spinal analgesia.
18F-FDOPA PET imaging of brain tumors: comparison study with 18F-FDG PET and evaluation of diagnostic accuracy.

UNLABELLED We evaluated the amino acid and glucose metabolism of brain tumors by using PET with 3,4-dihydroxy-6-(18)F-fluoro-l-phenylalanine ((18)F-FDOPA) and (18)F-FDG. METHODS Eighty-one patients undergoing evaluation for brain tumors were studied. Initially, 30 patients underwent PET with (18)F-FDOPA and (18)F-FDG within the same week. Tracer kinetics in normal brain and tumor tissues were estimated. PET uptake was quantified by use of standardized uptake values and the ratio of tumor uptake to normal hemispheric tissue uptake (T/N). In addition, PET uptake with (18)F-FDOPA was quantified by use of ratios of tumor uptake to striatum uptake (T/S) and of tumor uptake to white matter uptake. The accuracies of (18)F-FDOPA and (18)F-FDG PET were determined by comparing imaging data with histologic findings and findings of clinical follow-up of up to 31 mo (mean, 20 mo). To further validate the accuracy of (18)F-FDOPA PET, (18)F-FDOPA PET was performed with an additional 51 patients undergoing brain tumor evaluation. RESULTS Tracer uptake in tumors on (18)F-FDOPA scans was rapid, peaking at approximately 15 min after intravenous injection. Tumor uptake could be distinguished from that of the striatum by the difference in peak times. Both high-grade and low-grade tumors were well visualized with (18)F-FDOPA. The sensitivity for identifying tumors was substantially higher with (18)F-FDOPA PET than with (18)F-FDG PET at comparable specificities, as determined by simple visual inspection, especially for the assessment of low-grade tumors. Using receiver-operating-characteristic curve analysis, we found the optimal threshold for (18)F-FDOPA to be a T/S of greater than 1.0 (sensitivity, 96%; specificity, 100%) or a T/N of greater than 1.3 (sensitivity, 96%; specificity, 86%). The high diagnostic accuracy of (18)F-FDOPA PET at these thresholds was confirmed with the additional 51 patients (a total of 81 patients: sensitivity, 98%; specificity, 86%; positive predictive value, 95%; negative predictive value, 95%). No significant difference in tumor uptake on (18)F-FDOPA scans was seen between low-grade and high-grade tumors (P = 0.40) or between contrast-enhancing and nonenhancing tumors (P = 0.97). Radiation necrosis was generally distinguishable from tumors on (18)F-FDOPA scans (P < 0.00001). CONCLUSION (18)F-FDOPA PET was more accurate than (18)F-FDG PET for imaging of low-grade tumors and evaluating recurrent tumors. (18)F-FDOPA PET may prove especially useful for imaging of recurrent low-grade tumors and for distinguishing tumor recurrence from radiation necrosis.
Bruton tyrosine kinase gene mutations in Turkish patients with presumed X‐linked agammaglobulinemia

X‐linked agammglobulinemia (XLA) is a ptototypical humoral immunodeficiency caused by mutations in the gene coding for Bruton tyrosine kinase (BTK). The genetic defect in XLA impairs early B cell development resulting in marked reduction of mature B cells in the blood. Studies from different countries have demonstrated that approximately 90% of males with presumed XLA bear mutations in BTK. In this study, we report for the first time the occurrence of BTK mutations in Turkey. We performed mutational analysis of the BTK gene in 16 Turkish male patients from 13 separate families with presumed XLA based on abnormally low peripheral blood B‐cell numbers (lt; 1%), hypogammaglobulinemia, and recurrent bacterial infections. We found that in nine of the 13 families (69%) a Btk mutation caused XLA. Two of the mutations were previously described, but seven novel mutations were identified: two missense (Y39C, G584R), one nonsense (Q343X), and 4 deletions (1800‐1821del, 1843‐1847del, 1288‐1292del, 291del) resulting in frameshift and premature stop codon. By contrast, no mutations in the BTK gene were identified in the other 4 families. A consanguinity in three of these families raises the possibility that mutations in other autosomal genes which affect early B cell development may contribute to their phenotype resembling XLA. Hum Mutat 18:356, 2001. © 2001 Wiley‐Liss, Inc.
Enzymatic Properties of a Novel Liquefying α-Amylase from an Alkaliphilic Bacillus Isolate and Entire Nucleotide and Amino Acid Sequences

ABSTRACT A novel liquefying α-amylase (LAMY) was found in cultures of an alkaliphilic Bacillus isolate, KSM-1378. The specific activity of purified LAMY was approximately 5,000 U mg of protein−1, a value two- to fivefold greater between pH 5 and 10 than that of an industrial, thermostable Bacillus licheniformis enzyme. The enzyme had a pH optimum of 8.0 to 8.5 and displayed maximum activity at 55°C. The molecular mass deduced from sodium dodecyl sulfate-polyacrylamide gel electrophoresis was approximately 53 kDa, and the apparent isoelectric point was around pH 9. This enzyme efficiently hydrolyzed various carbohydrates to yield maltotriose, maltopentaose, maltohexaose, and maltose as major end products after completion of the reaction. Maltooligosaccharides in the maltose-to-maltopentaose range were unhydrolyzable by the enzyme. The structural gene for LAMY contained a single open reading frame 1,548 bp in length, corresponding to 516 amino acids that included a signal peptide of 31 amino acids. The calculated molecular mass of the extracellular mature enzyme was 55,391 Da. LAMY exhibited relatively low amino acid identity to other liquefying amylases, such as the enzymes from B. licheniformis (68.9%), Bacillus amyloliquefaciens (66.7%), and Bacillus stearothermophilus (68.6%). The four conserved regions, designated I, II, III, and IV, and the putative catalytic triad were found in the deduced amino acid sequence of LAMY. Essentially, the sequence of LAMY was consistent with the tertiary structures of reported amylolytic enzymes, which are composed of domains A, B, and C and which include the well-known (α/β)8 barrel motif in domain A.
Email Volume Optimization at LinkedIn

Online social networking services distribute various types of messages to their members. Common types of messages include news, connection requests, membership notifications, promotions and event notifications. Such communication, if used judiciously, can provide an enormous value to members thereby keeping them engaged. However sending a message for every instance of news, connection request, or the like can result in an overwhelming number of messages in a member's mailbox. This may result in reduced effectiveness of communication if the messages are not sufficiently relevant to the member's interests. It may also result in a poor brand perception of the networking service. In this paper we discuss our strategy and experience with regard to the problem of email volume optimization at LinkedIn. In particular, we present a cost-benefit analysis of sending emails, the key factors to administer an effective volume optimization, our algorithm for volume optimization, the architecture of the supporting system and experimental results from online A/B tests.
Cloud gaming: architecture and performance

Recent advances in cloud technology have turned the idea of cloud gaming into a reality. Cloud gaming, in its simplest form, renders an interactive gaming application remotely in the cloud and streams the scenes as a video sequence back to the player over the Internet. This is an advantage for less powerful computational devices that are otherwise incapable of running high-quality games. Such industrial pioneers as Onlive and Gaikai have seen success in the market with large user bases. In this article, we conduct a systematic analysis of state-of-the-art cloud gaming platforms, and highlight the uniqueness of their framework design. We also measure their real world performance with different types of games, for both interaction latency and streaming quality, revealing critical challenges toward the widespread deployment of cloud gaming.
Multiple Emotions Detection in Conversation Transcripts

In this paper, we present a method of predicting emotions from multi-label conversation transcripts. The transcripts are from a movie dialog corpus and annotated partly by 3 annotators. The method includes building an emotion lexicon bootstrapped from Wordnet following the notion of Plutchik’s basic emotions and dyads. The lexicon is then adapted to the training data by using a simple Neural Network to ﬁne-tune the weights toward each basic emotion. We then use the adapted lexicon to extract the features and use them for another Deep Network which does the detection of emotions in conversation transcripts. The experiments were conducted to conﬁrm the effectiveness of the method, which turned out to be nearly as good as a human annotator.
Obesity and post‐operative complications in patients undergoing non‐bariatric surgery

As the prevalence of obesity continues to rise in society, an increasing number of patients undergoing non‐bariatric surgery will be obese. Obesity is known to increase morbidity and mortality in the general population and thus is perceived as a risk factor for adverse post‐surgical outcomes. This association is not clear‐cut, however, and there is a lack of consensus in the literature on the risk between obesity and specific complications, in particular relating to infection, wound healing, respiratory and venous thromboembolism. The paucity of studies, as well as a lack of consistency of definition of obesity, with an over‐reliance on body mass index rather than body composition analysis, may underlie this confusion. Emerging concepts position central/visceral adipose tissue as potentially key to the pathogenesis of the comorbidities associated with obesity, thus this article reviews emerging research investigating the association between visceral obesity, the metabolic syndrome and resulting post‐operative complications. It is hypothesized that the state of chronic inflammation and dysmetabolism observed in visceral obese patients negatively influences post‐operative outcomes and represents a potential target for pharmaconutrition. The need for further research investigating the influence of visceral adiposity on immune function post surgery and its impact on post‐operative morbidity and mortality is highlighted.
On the use of location window in geo-intelligent HTTP adaptive video streaming

HTTP adaptive video streaming has become the de facto standard for media data delivery in the Internet. Mobile users are increasingly accessing video streaming services while traveling in fast-moving vehicles (e.g., public transport). The inherent high-speed mobility in these scenarios escalates bandwidth uncertainty and seriously degrades the performance of HTTP adaptive video streaming. This paper proposes a location window based geo-intelligent adaptive streaming algorithm, which adapts to the geo-spatial bandwidth variations experienced by a fast-moving user by adjusting the quality of the next chunk based on the estimated bandwidth at the next X locations of the mobile user. In order to realize geo-intelligence, we introduce a neural network model for accurately creating bandwidth maps that store location-specific bandwidth knowledge. By incorporating both these contributions in conjunction with real-world mobile broadband bandwidth traces from a metropolitan area, we present a systematic study to explore the effects of varying the size of the location window on the user-perceived Quality of Experience (QoE). The evaluation results demonstrate that an optimum location window can be identified, which can almost entirely eliminate playout buffer underruns, thus leading to a smooth and high-quality streaming experience.
Temperature and Strain Sensing With Femtosecond Laser Written Bragg Gratings in Defect and Nondefect Suspended-Silica-Core Fibers

The spectral behavior in the C-band of fiber Bragg gratings (FBGs) was analyzed as a function of temperature and strain. The FBGs were fabricated in pure silica four-leaf-clover-shaped suspended-core fibers by (DUV) femtosecond laser exposure (3.6 W at 800 nm, 130 fs, 1 kHz frequency tripled to 350 fs, 650 mW at 267 nm). A defect fiber (with a hollow hole in the core) and nondefect fiber were compared both yielding ≈1 pm/με sensitivity to strain but different sensitivity to temperature (from 3.0 pm/°C to 8.4 pm/°C for the defect fiber and 10 pm/°C for the nondefect fiber). The 16% to 70% relative difference between the thermal coefficients of the two fibers, together with their similar strain sensitivity enables the simultaneous measurement of strain and temperature.