Miracle-dz/UniFAR-FTUs huggingface dataset:
A Compressive Sensing Approach to Community Detection with Applications

The community detection problem for graphs asks one to partition the n vertices V of a graph G into k communities, or clusters, such that there are many intracluster edges and few intercluster edges. Of course this is equivalent to finding a permutation matrix P such that, if A denotes the adjacency matrix of G, then PAP^T is approximately block diagonal. As there are k^n possible partitions of n vertices into k subsets, directly determining the optimal clustering is clearly infeasible. Instead one seeks to solve a more tractable approximation to the clustering problem. In this paper we reformulate the community detection problem via sparse solution of a linear system associated with the Laplacian of a graph G and then develop a two-stage approach based on a thresholding technique and a compressive sensing algorithm to find a sparse solution which corresponds to the community containing a vertex of interest in G. Crucially, our approach results in an algorithm which is able to find a single cluster of size n_0 in O(nlog(n)n_0) operations and all k clusters in fewer than O(n^2ln(n)) operations. This is a marked improvement over the classic spectral clustering algorithm, which is unable to find a single cluster at a time and takes approximately O(n^3) operations to find all k clusters. Moreover, we are able to provide robust guarantees of success for the case where G is drawn at random from the Stochastic Block Model, a popular model for graphs with clusters. Extensive numerical results are also provided, showing the efficacy of our algorithm on both synthetic and real-world data sets.
A Lateral Flow Assay for Quantitative Detection of Amplified HIV-1 RNA

Although the accessibility of HIV treatment in developing nations has increased dramatically over the past decade, viral load testing to monitor the response of patients receiving therapy is often unavailable. Existing viral load technologies are often too expensive or resource-intensive for poor settings, and there is no appropriate HIV viral load test currently available at the point-of-care in low resource settings. Here, we present a lateral flow assay that employs gold nanoparticle probes and gold enhancement solution to detect amplified HIV RNA quantitatively. Preliminary results show that, when coupled with nucleic acid sequence based amplification (NASBA), this assay can detect concentrations of HIV RNA that match the clinically relevant range of viral loads found in HIV patients. The lateral flow test is inexpensive, simple and rapid to perform, and requires few resources. Our results suggest that the lateral flow assay may be integrated with amplification and sample preparation technologies to serve as an HIV viral load test for low-resource settings.
Grade-Level Declines in Perceived Academic Support From Peers: A Moderated Mediation Analysis

Prior research demonstrates that perceived academic support from peers positively predicts school adjustment. In this cross-sectional study, we provide evidence that perceived academic support from peers declines from 3rd to 8th grade and that this decline is partially mediated by grade-level declines in perceptions that academic success disclosures are normative and will elicit positive responses, especially among students who hold social demonstration goals. Discussion focuses on the importance of assessing changing peer norms for positive behaviors, including a willingness to celebrate peers’ academic successes.
The effects of short afternoon nap and bright light on task switching performance and error-related negativity

The aim of the present study was to demonstrate the effects of a short nap (20 min) and bright light (>2000 lux) in the afternoon on task switching ability (i.e., switch cost and mixing cost) and error-related negativity (Ne/ERN). The effects of a short nap and bright light on task switching performance have been less reported despite the importance and frequency of task switching as a common activity in many occupational situations. Sixteen volunteers performed a switching task twice a day (1200–1330 h and 1430–21600 h). Participants completed a total of four experimental conditions (control, short nap, bright light, and short nap with bright light). A short nap was taken during the break between the first and second tasks. During the second task, bright light treatment was applied in two of the four conditions. A short afternoon nap improved task-switching performance (i.e., switch cost) and enlarged Ne/ERN amplitude. No effects were found for light conditions on task-switching performance and Ne/ERN amplitude. The results suggest that: (i) a short afternoon nap improves executive functions and self-monitoring that involve the prefrontal cortex; and (ii) the effect of bright light on task-switching performance is smaller compared to a short nap.
Role of Folic Acid on Symptoms of Chronic Arsenic Toxicity

Background: Chronic arsenic toxicity (Arsenicosis) due to drinking of arsenic contaminated ground water is a global problem. However, its treatment is unsatisfactory. Methylation of arsenic facilitates its urinary excretion. Persons with relatively lower proportion of urinary dimethyl arsenic acid (DMA) are found to have at greater risk of developing symptoms of arsenicosis including its complications. The biochemical pathway responsible for methylation of arsenic is a folate-dependent pathway. Studies in rodents and humans suggest that folate nutritional status influences the metabolism of arsenic. Methods: The present study compares the effect of giving folic acid on 32 arsenicosis patients during a 6-month period and comparing the results with clinical effect of taking only arsenic-free safe water on 45 age and sex-matched arsenic-affected people for the same period. Results: There was significant improvement of arsenical skin lesion score of both patients treated with folic acid (2.96 ± 1.46 to 1.90 ± 0.90, P < 0.001) and arsenic free safe water (2.91 ± 1.26 to 1.62 ± 1.05, P < 0.001) for a period of 6 months. Significant improvement in systemic disease score was also observed from the baseline systemic score in folic acid treated group (4.78 ± 3.43 to 1.00 ± 1.56, P < 0.001) and the group treated with arsenic-free water (1.87 ± 2.11 to 0.82 ± 1.62, P < 0.001). However, there was a significant increased improvement of systematic disease score in the folic acid treated group compared to the control group taking arsenic free water (P < 0.001). Conclusions: This study provides evidence that folic acid treatment in arsenicosis cases could help in reducing clinical symptoms of arsenicosis.
Genetic network underlying temperature‐dependent sex determination is endogenously regulated by temperature in isolated cultured Trachemys scripta gonads

In reptiles with temperature‐dependent sex determination, gonadogenesis is initially directed by the incubation temperature of the egg during the middle third of embryonic development. The mechanism by which temperature is transduced into a sex‐determining molecular signal remains a mystery, and here we examine the molecular network underlying sex determination in gonads in vitro. We use a whole organ culture system to show that expression of putative members of the sex‐determining network (Dmrt1, Sox9, Mis, and FoxL2) are regulated by temperature endogenously within cells in the bipotential gonad and do not require other embryonic tissues to be expressed in a normal pattern in the red‐eared slider turtle, Trachemys scripta. Furthermore, following a change in temperature, these factors exhibit temperature‐responsive expression patterns that last for the duration of gonadogenesis. Finally, mosaic misexpression of a fusion Sox9 construct demonstrates the ability to functionally manipulate the gonad at the molecular level. Developmental Dynamics 239:1061–1075, 2010. © 2010 Wiley‐Liss, Inc.
Functional Zone Based Hierarchical Demand Prediction For Bike System Expansion

Bike sharing systems, aiming at providing the missing links in public transportation systems, are becoming popular in urban cities. Many providers of bike sharing systems are ready to expand their bike stations from the existing service area to surrounding regions. A key to success for a bike sharing systems expansion is the bike demand prediction for expansion areas. There are two major challenges in this demand prediction problem: First. the bike transition records are not available for the expansion area and second. station level bike demand have big variances across the urban city. Previous research efforts mainly focus on discovering global features, assuming the station bike demands react equally to the global features, which brings large prediction error when the urban area is large and highly diversified. To address these challenges, in this paper, we develop a hierarchical station bike demand predictor which analyzes bike demands from functional zone level to station level. Specifically, we first divide the studied bike stations into functional zones by a novel Bi-clustering algorithm which is designed to cluster bike stations with similar POI characteristics and close geographical distances together. Then, the hourly bike check-ins and check-outs of functional zones are predicted by integrating three influential factors: distance preference, zone-to-zone preference, and zone characteristics. The station demand is estimated by studying the demand distributions among the stations within the same functional zone. Finally, the extensive experimental results on the NYC Citi Bike system with two expansion stages show the advantages of our approach on station demand and balance prediction for bike sharing system expansions.
Small-Dose Intrathecal Clonidine and Isobaric Bupivacaine for Orthopedic Surgery: A Dose-Response Study

We examined the dose-response relationship of intrathecal clonidine at small doses (≤150 &mgr;g) with respect to prolonging bupivacaine spinal anesthesia. We aimed for establishing doses of intrathecal clonidine that would produce clinically relevant prolongation of spinal anesthesia and pain relief without significant side effects. Eighty orthopedic patients were randomly assigned to intrathecally receive isobaric 0.5% bupivacaine, 18 mg, plus saline (Group 1), clonidine 37.5 &mgr;g (Group 2), clonidine 75 &mgr;g (Group 3), and clonidine 150 &mgr;g (Group 4). Duration of the sensory block (regression below level L1) was increased in patients receiving intrathecal clonidine: 288 ± 62 min (Group 1, control), 311 ± 101 min in Group 2 (+8%), 325 ± 69 min in Group 3 (+13%), and 337 ± 78 min in Group 4 (+17%) (estimated parameter for dose 0.23 [95% confidence interval −0.05–0.50]). Duration of pain relief from intrathecal clonidine administration until the first request for supplemental analgesia was significantly prolonged: 295 ± 80 min (Group 1, control), 343 ± 75 min in Group 2 (+16%), 381 ± 117 min in Group 3 (+29%), and 445 ± 136 min in Group 4 (+51%) (estimated parameter for dose 1.02 [95% confidence interval 0.59–1.45]). Relative hemodynamic stability was maintained and there were no between-group differences in the sedation score. We conclude that small doses of intrathecal clonidine (≤150 &mgr;g) significantly prolong the anesthetic and analgesic effects of bupivacaine in a dose-dependent manner and that 150 &mgr;g of clonidine seems to be the preferred dose, in terms of effect versus unwarranted side effects, when prolongation of spinal anesthesia is desired.
A Precision Microbiome Approach Using Sucrose for Selective Augmentation of Staphylococcus epidermidis Fermentation against Propionibacterium acnes

Acne dysbiosis happens when there is a microbial imbalance of the over-growth of Propionibacterium acnes (P. acnes) in the acne microbiome. In our previous study, we demonstrated that Staphylococcus epidermidis (S. epidermidis, a probiotic skin bacterium) can exploit glycerol fermentation to produce short-chain fatty acids (SCFAs) which have antimicrobial activities to suppress the growth of P. acnes. Unlike glycerol, sucrose is chosen here as a selective fermentation initiator (SFI) that can specifically intensify the fermentation activity of S. epidermidis, but not P. acnes. A co-culture of P. acnes and fermenting S. epidermidis in the presence of sucrose significantly led to a reduction in the growth of P. acnes. The reduction was abolished when P. acnes was co-cultured with non-fermenting S. epidermidis. Results from nuclear magnetic resonance (NMR) analysis revealed four SCFAs (acetic acid, butyric acid, lactic acid, and succinic acid) were detectable in the media of S. epidermidis sucrose fermentation. To validate the interference of S. epidermidis sucrose fermentation with P. acnes, mouse ears were injected with both P. acnes and S. epidermidis plus sucrose or phosphate buffered saline (PBS). The level of macrophage-inflammatory protein-2 (MIP-2) and the number of P. acnes in ears injected with two bacteria plus sucrose were considerably lower than those in ears injected with two bacteria plus PBS. Our results demonstrate a precision microbiome approach by using sucrose as a SFI for S. epidermidis, holding future potential as a novel modality to equilibrate dysbiotic acne.
Inverse association of esophageal eosinophilia with Helicobacter pylori based on analysis of a US pathology database.

BACKGROUND & AIMS Eosinophilic esophagitis (EoE) is of increasing prevalence and believed to result from allergic processes. Helicobacter pylori has been inversely associated with allergic diseases, but there is no known relationship between H pylori, EoE, and esophageal eosinophilia. We investigated the association between esophageal eosinophilia and H pylori infection. METHODS We performed a cross-sectional study of data, collected from a US pathology database, on 165,017 patients in the United States who underwent esophageal and gastric biopsies from 2008 through 2010. Patients with and without H pylori on gastric biopsy were compared, and odds of esophageal eosinophilia were determined. RESULTS From the data analyzed, 56,301 (34.1%) had normal esophageal biopsy specimens, 5767 (3.5%) had esophageal eosinophilia, and 11,170 (6.8%) had H pylori infection. Esophageal eosinophilia was inversely associated with H pylori (odds ratio [OR], 0.77; 95% confidence interval [CI], 0.69-0.87). Compared with patients with normal esophageal biopsy specimens, odds of H pylori were reduced among patients with ≥ 15 eosinophils per high-power field (eos/hpf) (OR, 0.79; 95% CI, 0.70-0.88), ≥ 45 eos/hpf (OR, 0.75; 95% CI, 0.61-0.93), ≥ 75 eos/hpf (OR, 0.72; 95% CI, 0.50-1.03), and ≥ 90 eos/hpf (OR, 0.52; 95% CI, 0.31-0.87) (P for trend <.001). A similar dose-response trend was observed for increasing clinical suspicion for EoE and decreasing prevalence of H pylori. Additionally, severity of histologic effects of H pylori was inversely associated with esophageal eosinophilia. All trends held in multivariate analysis. CONCLUSIONS In a large cross-sectional analysis, H pylori infection was inversely associated with esophageal eosinophilia. This relationship could have implications for the pathogenesis and epidemiology of EoE.
Mission impossible? Communicating and sharing knowledge via information technology

This paper critiques the perspective that information technology can play a central role in knowledge-sharing processes. Fundamentally, it suggests that the nature of knowledge itself makes it extremely difficult and that quite specific conditions are required for information technology-based knowledge sharing to occur successfully. The paper proceeds by criticizing the objectivist philosophy of knowledge, which typically underpins the literature advocating information technology-based knowledge management. The centre point of this critique involves questioning one of the foundational assumptions of the objectivist perspective, namely the dichotomy made between tacit and explicit knowledge. Instead, a ‘practice’-based philosophy of knowledge is proposed that suggests that all knowledge has both tacit and explicit components, is to some extent embodied in human brains and bodies and is embedded in organizational routines, practices and contexts. These characteristics therefore suggest that the role of information technology systems in the sharing of knowledge is likely to be somewhat limited.
Reefs under Siege—the Rise, Putative Drivers, and Consequences of Benthic Cyanobacterial Mats

Benthic cyanobacteria have commonly been a small but integral component of coral reef ecosystems, fulfilling the critical function of introducing bioavailable nitrogen to an inherently oligotrophic environment. Though surveys may have previously neglected benthic cyanobacteria, or grouped them with more conspicuous benthic groups, emerging evidence strongly indicates that they are becoming increasingly prevalent on reefs worldwide. Some species can form mats comprised by a diverse microbial consortium which allows them to exist across a wide range of environmental conditions. This review evaluates the putative driving factors of increasing benthic cyanobacterial mats, including climate change, declining coastal water quality, iron input, and overexploitation of key consumer and ecosystem engineer species. Ongoing global environmental change can increase growth rates and toxin production of physiologically plastic benthic cyanobacterial mats, placing them at a considerable competitive advantage against reef-building corals. Once established, strong ecological feedbacks [e.g., inhibition of coral recruitment, release of dissolved organic carbon (DOC)] reinforce reef degradation. The review also highlights previously overlooked implications of mat proliferation, which can extend beyond reef health and affect human health and welfare. Though identifying (opportunistic) consumers of mats remains a priority, their perceived low palatability implies that herbivore management alone may be insufficient to control their proliferation and must be accompanied by local measures to improve water quality and watershed management.
The State of the Art in Cartograms

Cartograms combine statistical and geographical information in thematic maps, where areas of geographical regions (e.g., countries, states) are scaled in proportion to some statistic (e.g., population, income). Cartograms make it possible to gain insight into patterns and trends in the World around us and have been very popular visualizations for geo‐referenced data for over a century. This Work surveys cartogram research in visualization, cartography and geometry, covering a broad spectrum of different cartogram types: from the traditional rectangular and table cartograms, to Dorling and diffusion cartograms. A particular focus is the study of the major cartogram dimensions: statistical accuracy, geographical accuracy, and topological accuracy. We review the history of cartograms, describe the algorithms for generating them, and consider task taxonomies. We also review quantitative and qualitative evaluations, and we use these to arrive at design guidelines and research challenges.
Synthesis and application of N‐[1‐(4‐(4‐fluorophenyl)‐2,6‐dioxocyclohexylidene)ethyl] (Fde)‐protected amino acids for optimization of solid‐phase peptide synthesis using gel‐phase 19F NMR spectroscopy

N‐[1‐(4‐(4‐fluorophenyl)‐2,6‐dioxocyclohexylidene)ethyl] (Fde) protected amino acids have been prepared and applied in solid‐phase peptide synthesis monitored by gel‐phase 19F NMR spectroscopy. The Fde protective group could be cleaved with 2% hydrazine or 5% hydroxylamine solution in DMF as determined with gel‐phase 19F NMR spectroscopy. The dipeptide Ac‐L‐Val‐L‐Val‐NH2 12 was constructed using Fde‐L‐Val‐OH and no noticeable racemization took place during the amino acid coupling with N,N′‐diisopropylcarbodiimide and 1‐hydroxy‐7‐azabenzotriazole or Fde deblocking. To extend the scope of Fde protection, the hydrophobic nonapeptide LLLLTVLTV from the signal sequence of mucin MUC1 was successfully prepared using Fde‐L‐Leu‐OH at diagnostic positions. Copyright © 2009 European Peptide Society and John Wiley & Sons, Ltd.
An ironic effect of monitoring closeness

Most theories of goal pursuit underscore the beneficial consequences of monitoring progress towards goals. However, effects of affect labelling and dissociations between experience and meta-consciousness suggest that monitoring may not always facilitate goal pursuit. We predicted that in the case of pursuing interpersonal closeness, intense monitoring of progress would have a detrimental effect. We tested this hypothesis with the intimate conversation procedure, adapted from Aron, Melinat, Aron, Vallone, and Bator (1997). Participants in the closeness-monitoring condition asked themselves every five minutes in the course of a 45-minute interaction with a partner whether they felt any closer to their partner, whereas participants in the control condition monitored the room temperature. As predicted, intense monitoring interfered with achieving a feeling of closeness, as measured by sitting distance between pair members following the intimate conversation procedure. We discuss the possibility that monitoring would also be detrimental for achieving other goals that are internal states.
Distribution of WLAN received signal strength indication for indoor location determination

Indoor positioning systems are platforms required to provide location information for indoor location-aware computing. This study focuses on a type of indoor positioning systems called location fingerprinting technique that utilizes received signal strength indication (RSSI) of wireless local area network (WLAN) interfaces. Thus far, many characteristics of RSSI have not been thoroughly investigated. Many researchers have relied on the RSSI as sensor information to determine objects location while ignoring the characteristic of RSSI. Therefore, this paper looks into underlying mechanism of RSSI from the indoor positioning systems perspective. In particular, the distributions of RSSI from five different IEEE 802.11b/g WLAN interfaces are investigated using extensive measurement experiments. Desired properties of WLAN interfaces for location fingerprinting are also identified based on the measurement results. The ultimate goal is to use additional knowledge gained here to improve positioning performance and to model location fingerprinting based indoor positioning systems.
Visualization of outflow tract development in the absence of Tbx1 using an FgF10 enhancer trap transgene

Tbx1, the major gene underlying del22q11.2 or DiGeorge syndrome in humans, is required for normal development and septation of the cardiac outflow tract. The fibroblast growth factor 10 gene (Fgf10) and an Fgf10 enhancer trap transgene are expressed in outflow tract myocardial progenitor cells of the anterior heart field. To visualize outflow tract development in the absence of Tbx1, we have analyzed the expression profile of the Fgf10 enhancer trap transgene during outflow tract development in Tbx1−/− embryos. Transgene expression confirms hypoplasia of the distal outflow tract in the absence of Tbx1, and altered expression in pharyngeal mesoderm reveals loss of specific bilateral subpopulations of outflow tract progenitor cells and disruption of the posterior boundary of the anterior heart field. Our results support the conclusion that Tbx1 controls deployment of Fgf10‐expressing progenitor cells during heart tube extension. Furthermore, although normal Fgf10 levels are dependent on Tbx1, loss of Fgf10 alleles does not significantly modify the cardiac phenotype of Tbx1 heterozygous or homozygous mutant embryos. Developmental Dynamics 236:821–828, 2007. © 2007 Wiley‐Liss, Inc.