Miracle-dz/UniFAR-FTUs huggingface dataset:
Immune Modulator Pidotimod Decreases the In Vitro Expression of CD30 in Peripheral Blood Mononuclear Cells of Atopic Asthmatic and Normal Children

Recurrent viral infections are frequently observed in children with atopic asthma. In this study we investigated the ability of the synthetic immunomodulator pidotimod to affect in vitro the phenotype and/or cytokine profile of blood cells in relation to atopic asthma. Peripheral blood mononuclear cells were isolated from 13 atopic asthmatic and 9 normal children and stimulated in culture with mitogen either in the presence or not of the drug. Expression of surface markers was evaluated by flow cytometry, and production of interleukin‐4 and interferon‐gamma was measured in supernatants. Pidotimod was able to down‐regulate the expression of CD30 on cells from both atopic and normal subjects. Because CD30 has been associated with Th‐2 cells, this observation supports the possibility of pidotimod being able to affect the Th‐1/Th‐2 balance in atopic asthma.
Equity Volatility as a Determinant of Future Term-Structure Volatility

We show that equity volatility serves as a determinant of future Treasury term-structure volatility over the recent October 1997 to June 2013 period. We find that equity volatility contains incrementally reliable information for the subsequent volatility of: (1) 10-year and 30-year bond futures returns, (2) the term-structure׳s level, and (3) the term-structure׳s slope. We present additional evidence that suggests a flight-to-quality/flight-from-quality pricing avenue is a likely contributor to the volatility linkages, where time-varying economic uncertainty can generate both a large positive serial correlation in stock volatility and a time-variation in the precautionary savings motive and diversification benefits of holding bonds.
Product market competition and the cost of equity capital: evidence from China

This study examines how product market competition affects the cost of equity capital in the incomplete competition and transitional economy setting in China, and reports that firms in more competitive industries have lower the cost of equity. We explain that technical innovation, production efficiency, external governance, and managerial incentives induced by increased competition reduce systematic economic uncertainty in China, and find their mediating effects on the competition cost of equity relation. We also find that better development of non-state economy, less government intervention, entrance to the World Trade Organization, and higher banking competition strengthen the competition cost of equity relation.
00 PM-3 : 00 PM Alcohol Consumption Among Hospitality Students and Hospitality Employees : A Replication and Pilot Study

This is a descriptive study that investigates alcohol consumption among hospitality students and hospitality employees. Based on prior research conducted in Scandinavia and the United States, comparisons are made to other non-hospitality majors as well as those employed in non-hospitality industries. In a general sense the claim that hospitality students and hospitality employees consume alcohol at higher rates than students and employees with different affiliations is confirmed. Explanations for the disparate alcohol consumption are proposed.
Relational Capital and Performance of International Joint Ventures in Vietnam

Relational capital (RC), which is defined as mutual trust, respect, understanding, and close friendship between individuals in a business partnership, is one of the foremost important elements of the international joint venture (IJV) relationship. However, only relatively few researchers have hitherto attempted to measure this concept or its antecedents and consequences on joint ventures (JVs). This article examines the links between RC and relational factors, such as inter-partner flexibility, cultural sensitivity, goal clarity, information exchange and conflict management, and how RC contributes to performance of the IJVs in Vietnam. Based on an extensive questionnaire survey, the study found significant relationships between these relational factors and RC and between RC and performance of the IJVs. The findings suggest that investment in RC between partners is critical for the success of the IJV. In this regard, this research highlights the mediating roles of inter-partner flexibility, goal clarity, and conflict management.
Direct cytotoxic action of Shiga toxin on human vascular endothelial cells

To help explain a role of the Shiga toxin family in hemorrhagic colitis and hemolytic-uremic syndrome in humans, it has been hypothesized that these toxins cause direct damage to the vascular endothelium. We now report that Shiga toxin purified from Shigella dysenteriae 1 does indeed have a direct cytotoxic effect on vascular endothelial cells in cultures. Human umbilical vein endothelial cells (HUVEC) in confluent monolayers were reduced 50% by 10(-8) M Shiga toxin after a lag period of 48 to 96 h. In comparison, nonconfluent HUVEC were reduced 50% by 10(-10) M Shiga toxin within a 24-h period. These data suggest that dividing endothelial cells are more sensitive to Shiga toxin than are quiescent cells in confluent monolayers. Both confluent and nonconfluent HUVEC specifically bound 125I-Shiga toxin. However, in response to the toxin, rates of incorporation of [3H]leucine into protein were more severely reduced in nonconfluent cells than in confluent cells. Toxin inhibition of protein synthesis preceded detachment of cells from the substratum. The specific binding of 125I-Shiga toxin to human endothelial cells and the cytotoxic response were both toxin dose dependent and neutralized by anti-Shiga toxin antibody. Heat-denatured Shiga toxin was without the cytotoxic effect. In addition, the complete culture system contained less than 0.1 ng of bacterial endotoxin per ml, as measured by the Limulus amoebocyte lysate test.
Carbon monoxide column retrieval for clear-sky and cloudy atmospheres: a full-mission data set from SCIAMACHY 2.3 μm reflectance measurements

Abstract. We discuss the retrieval of carbon monoxide (CO) vertical column densities from clear-sky and cloud contaminated 2311–2338 nm reflectance spectra measured by the Scanning Imaging Absorption Spectrometer for Atmospheric Chartography (SCIAMACHY) from January 2003 until the end of the mission in April 2012. These data were processed with the Shortwave Infrared CO Retrieval algorithm (SICOR) that we developed for the operational data processing of the Tropospheric Monitoring Instrument (TROPOMI) that will be launched on ESA's Sentinel-5 Precursor (S5P) mission. This study complements previous work that was limited to clear-sky observations over land. Over the oceans, CO is estimated from cloudy-sky measurements only, which is an important addition to the SCIAMACHY clear-sky CO data set as shown by NDACC and TCCON measurements at coastal sites. For Ny-Alesund, Lauder, Mauna Loa and Reunion, a validation of SCIAMACHY clear-sky retrievals is not meaningful because of the high retrieval noise and the few collocations at these sites. The situation improves significantly when considering cloudy-sky observations, where we find a low mean bias b = ±6. 0 ppb and a strong correlation between the validation and the SCIAMACHY results with a mean Pearson correlation coefficient r = 0. 7. Also for land observations, cloudy-sky CO retrievals present an interesting complement to the clear-sky data set. For example, at the cities Tehran and Beijing the agreement of SCIAMACHY clear-sky CO observations with MOZAIC/IAGOS airborne measurements is poor with a mean bias of b = 171. 2 ppb and 57.9 ppb because of local CO pollution, which cannot be captured by SCIAMACHY. For cloudy-sky retrievals, the validation improves significantly. Here the retrieved column is mainly sensitive to CO above the cloud and so not affected by the strong local surface emissions. Adjusting the MOZAIC/IAGOS measurements to the vertical sensitivity of the retrieval, the mean bias adds up to b = 52. 3 ppb and 5.0 ppb for Tehran and Beijing. At the less urbanised region around the airport Windhoek, local CO pollution is less prominent and so MOZAIC/IAGOS measurements agree well with SCIAMACHY clear-sky retrievals with a mean bias of b = 15. 5 ppb, but can be even further improved for cloudy SCIAMACHY observations with a mean bias of b = 0. 2 ppb. Overall the cloudy-sky CO retrievals from SCIAMACHY short-wave infrared measurements present a major extension of the clear-sky-only data set, which more than triples the amount of data and adds unique observations over the oceans. Moreover, the study represents the first application of the S5P algorithm for operational CO data processing on cloudy observations prior to the launch of the S5P mission.
Difficulties with Testing for Causation

This paper examines the use of econometric tests for causality that are based on the work of Granger and Sims. The main conclusion is that it is not possible to infer the direction of causation from observed correlations. There are two reasons why the causality tests cannot reveal the direction of causation from observed correlations. First, the null hypothesis tested is necessary but not sufficient to imply causality. Second, any specification error renders the causality test results uninterpretable.
Capital Access Bonds: Contingent Capital with an Option to Convert

This paper argues that there is a Coasean Bargain available to banks, Long-term Investors, and Bank Regulators around a particular form of 'Contingent Capital'. By purchasing rights to issue equity in crisis events at a pre-specified price from Long-term Investors, banks can ensure that they will have sufficient regulatory capital available when they need it most: in a crisis. By selling these rights (effectively, a form of crisis insurance) long-term investors can monetize their counter-cyclical investments strategies in banks and, thus, obtain an adequate return as long-term investors. Bank Regulators, in turn, gain as they can thereby implement a more efficient form of equity-capital regulation. Banks have a special need to maintain their equity-capital base in the event of a crisis. Sovereign Wealth Funds and other long-term investors have proved to be the only available counterparties for banks in crisis times. This is why we argue that these investors must be able to monetize the countercyclical asset-management strategies they are trying to implement by obtaining a higher return on their cash reserves. The form of contingent capital we propose (Capital Access Bond) reflects a balance between investors’ preferences, issuers’ constraints, and regulators' objectives.
Challenging the Norm? The ‘Ethopolitics’ of Low-cost Homeownership in Scotland

Influenced by Nikolas Rose’s concept of ethopolitics, this paper explores attitudes to home and tenure amongst low-cost homeowners in Scotland. In doing so, it seeks to highlight the contested nature of contemporary governing practices and the way in which ‘governable subjects’ can challenge, reinterpret and resist dominant policy discourses, which promote homeownership as the preferred tenure of choice, whilst simultaneously pathologising and problematising social housing.
Are Visitor Arrivals to China Stationary? An Empirical Note

The tourism industry is one of the earliest industries in China to be opened up to the world, with a more open market and relatively sufficient competition. In this article, we use the panel seemingly unrelated regressions augmented Dickey–Fuller (SURADF) tests advanced by Breuer, McNown, and Wallace [(2001). Misleading inferences from panel unit-root tests with an illustration from purchasing power parity. Review of International Economics, 9(3), 482–493] to investigate whether visitor arrivals to China are stationary for the period 1995–2010. The empirical results from numerous conventional unit root tests indicate that tourist arrivals from 18 countries studied are non-stationary; however, when Breuer et al.'s (2001) panel SURADF tests are conducted, evidence of a unit root in visitor arrivals is found in only 13 countries. From these results, one particularly important policy implication for China emerges.
The Arab image in the minds of western image-makers

The purpose of this study is threefold. First is to investigate the image of Arabs in the minds of western image-makers and the consistency between the image and the attitude they have towards Arabs. Second is to identify the situation within which western image-makers perceive the Arab image and the interests that image serves. Third is to examine the overlap between the images of Arabs. Muslims and that of Islam and whether an image shift has occurred.
Diagnosis and management of congenital dyserythropoietic anemias

ABSTRACT Congenital dyserythropoietic anemias (CDAs) are inherited disorders hallmarked by chronic hyporegenerative anemia, relative reticulocytopenia, hemolytic component and iron overload. They represent a subtype of the inherited bone marrow failure syndromes, characterized by impaired differentiation and proliferation of the erythroid lineage. Three classical types were defined by marrow morphology, even if the most recent classification recognized six different genetic types. The pathomechanisms of CDAs are different, but all seem to involve the regulation of DNA replication and cell division. CDAs are often misdiagnosed, since either morphological abnormalities or clinical features can be commonly identified in other clinically-related anemias. However, differential diagnosis is essential for guiding both follow up and management of the patients.
Human epithelial hair follicle stem cells and their progeny: Current state of knowledge, the widening gap in translational research and future challenges

Epithelial hair follicle stem cells (eHFSCs) are required to generate, maintain and renew the continuously cycling hair follicle (HF), supply cells that produce the keratinized hair shaft and aid in the reepithelialization of injured skin. Therefore, their study is biologically and clinically important, from alopecia to carcinogenesis and regenerative medicine. However, human eHFSCs remain ill defined compared to their murine counterparts, and it is unclear which murine eHFSC markers really apply to the human HF. We address this by reviewing current concepts on human eHFSC biology, their immediate progeny and their molecular markers, focusing on Keratin 15 and 19, CD200, CD34, PHLDA1, and EpCAM/Ber‐EP4. After delineating how human eHFSCs may be selectively targeted experimentally, we close by defining as yet unmet key challenges in human eHFSC research. The ultimate goal is to transfer emerging concepts from murine epithelial stem cell biology to human HF physiology and pathology.
The Relationship Between the Comprehensiveness of Corporate Annual Reports and Firm Characteristics in Spain

Abstract Not much information exists in the international accounting literature on Spanish accounting. Spain is selected as a subject of study because it is different from those countries that are subjects of the research concerned with investigating the multivariate impact of firm characteristics on disclosure in annual reports and accounts. The conceptual model underlying our empirical tests is based on economic and political incentives for providing greater detail in corporate annual reports and accounts. The paper provides evidence that the amount of detail in Spanish corporate annual reports and accounts is increasing in firm size and stock exchange listing, and decreasing in liquidity.
Perceived value and customer loyalty in financial services

Taking into account how expensive it is to maintain customer loyalty programmes, it is necessary to know which aspects of the firm’s service are the ones that really deliver value to the customer. The aim of this paper is to study the relationships between perceived value, satisfaction and consumer loyalty in the financial services market, in order to know which factors are the most important for gaining the customers’ loyalty. A personal survey was made of 200 customers of financial entities, and structural equations models were used to test the relationships posited.
Recognition of Acceptor Proteins by UDP-D-xylose Proteoglycan Core Protein β-D-Xylosyltransferase*

The formation of chondroitin sulfate is initiated by xylosyltransferase (XT) transferring xylose from UDP-xylose to consensus serine residues of proteoglycan core proteins. Our alignment of 51 amino acid sequences of chondroitin sulfate attachment sites in 19 different proteins resulted in a consensus sequence for the recognition signal of XT. The complete recognition sequence is composed of the amino acids a-a-a-a-G—G-a-b-a, with a = E or D and b = G, E, or D. This sequence was confirmed by determination of the Michaelis-Menten constants for in vitro xylosylation of different synthetic proteins and peptides using an enriched XT preparation from conditioned cell culture supernatant of human chondrocytes. The highest acceptor activity was determined by the sequence Q-E-E-E-E-G—G-G-G-Q, which was found in the single chondroitin sulfate attachment site of bikunin, the inhibitory active component of the human inter-α-trypsin inhibitor. We determined the Michaelis-Menten constant (Km) of xylosylation of the synthetic bikunin analogous peptide Q-E-E-E-G-S-G-G-G-Q-K to be 22 μM, which was 9-fold decreased in comparison to deglycosylated core protein from bovine cartilage (188 μM), which was previously used as acceptor for the XT activity assay. The best XT acceptors were nonglycosylated recombinant wild-type bikunin (Km = 0.9 μM) and the recombinant [Val36,Val38]δ1,[Gly92,Ile94]δ2bikunin (Km = 0.6 μM), a variant without any inhibitory activity against serine proteinases. These results imply that the primary structure of the acceptor is not the only determinant for recognition by xylosyltransferase. Thus, protein conformation is also a main factor in determining xylosylation.
GAD65 Promoter Polymorphism rs2236418 Modulates Harm Avoidance in Women via Inhibition/Excitation Balance in the Rostral ACC

Anxiety disorders are common and debilitating conditions with higher prevalence in women. However, factors that predispose women to anxiety phenotypes are not clarified. Here we investigated potential contribution of the single nucleotide polymorphism rs2236418 in GAD2 gene to changes in regional inhibition/excitation balance, anxiety-like traits, and related neural activity in both sexes. One hundred and five healthy individuals were examined with high-field (7T) multimodal magnetic resonance imaging (MRI); including resting-state functional MRI in combination with assessment of GABA and glutamate (Glu) levels via MR spectroscopy. Regional GABA/Glu levels in anterior cingulate cortex (ACC) subregions were assessed as mediators of gene–personality interaction for the trait harm avoidance and moderation by sex was tested. In AA homozygotes, with putatively lower GAD2 promoter activity, we observed increased intrinsic neuronal activity and higher inhibition/excitation balance in pregenual ACC (pgACC) compared with G carriers. The pgACC drove a significant interaction of genotype, region, and sex, where inhibition/excitation balance was significantly reduced only in female AA carriers. This finding was specific for rs2236418 as other investigated single nucleotide polymorphisms of the GABA synthesis related enzymes (GAD1, GAD2, and GLS) were not significant. Furthermore, only in women there was a negative association of pgACC GABA/Glu ratios with harm avoidance. A moderated-mediation model revealed that pgACC GABA/Glu also mediated the association between the genotype variant and level of harm avoidance, dependent on sex. Our data thus provide new insights into the neurochemical mechanisms that control emotional endophenotypes in humans and constitute predisposing factors for the development of anxiety disorders in women. SIGNIFICANCE STATEMENT Anxiety disorders are among the most common and burdensome psychiatric disorders, with higher prevalence rates in women. The causal mechanisms are, however, poorly understood. In this study we propose a neurobiological basis that could help to explain female bias of anxiety endophenotypes. Using magnetic resonance brain imaging and personality questionnaires we show an interaction of the genetic variation rs2236418 in the GAD2 gene and sex on GABA/glutamate (Glu) balance in the pregenual anterior cingulate cortex (pgACC), a region previously connected to affect regulation and anxiety disorders. The GAD2 gene polymorphism further influenced baseline neuronal activity in the pgACC. Importantly, GABA/Glu was shown to mediate the relationship between the genetic variant and harm avoidance, however, only in women.
Implicit and explicit memory in patients with Parkinson's disease with and without dementia.

OBJECTIVE To study explicit and implicit memory processes in patients with Parkinson's disease. DESIGN Case-control design. All subjects were given a neuropsychological test battery, and the test scores were compared among the groups. SETTING Government-funded research facility. All subjects were examined as outpatients. PATIENTS We tested nondemented (n = 13) and demented (n = 5) patients with Parkinson's disease and normal controls (n = 12) matched for age, gender, and educational level. MAIN OUTCOME MEASURES Memory for verbal and pictorial stimuli under both explicit and implicit retrieval conditions. RESULTS Both nondemented and demented patients with Parkinson's disease exhibited impairment on tests of explicit memory. Their impairment could be graded based on the level of effort required by the task: impaired free recall in nondemented patients and impaired free recall, cued recall, and recognition in demented patients. By contrast, neither group showed evidence of impairment on automatic (modality monitoring and word frequency estimation) or implicit (word and picture fragment identification) memory tasks. Correlation analyses did not support any association between the effortful memory deficits and neurologic variables, mood, or performance on executive function tests. CONCLUSIONS Memory deficits in patients with Parkinson's disease primarily involve the conscious, effortful strategic aspects of searching long-term memory.
An R package for simulating growth and organic wastage in aquaculture farms in response to environmental conditions and husbandry practices

A new R software package, RAC, is presented. RAC allows to simulate the rearing cycle of 4 species, finfish and shellfish, highly important in terms of production in the Mediterranean Sea. The package works both at the scale of the individual and of the farmed population. Mathematical models included in RAC were all validated in previous works, and account for growth and metabolism, based on input data characterizing the forcing functions—water temperature, and food quality/quantity. The package provides a demo dataset of forcings for each species, as well as a typical set of husbandry parameters for Mediterranean conditions. The present work illustrates RAC main features, and its current capabilities/limitations. Three test cases are presented as a proof of concept of RAC applicability, and to demonstrate its potential for integrating different open products nowadays provided by remote sensing and operational oceanography.