Miracle-dz/UniFAR-FTUs huggingface dataset:
Energy balance , the Green – Naghdi – Rivlin

This paper studies the principle of invariance of balance of energy and its consequences for a system of interacting particles under groups of transformations. Balance of energy and its invariance is first examined in Euclidean space. Unlike the case of continuous media, it is shown that conservation and balance laws do not follow from the assumption of invariance of balance of energy under time-dependent isometries of the ambient space. However, the postulate of invariance of balance of energy under arbitrary diffeomorphisms of the ambient (Euclidean) space, does yield the correct conservation and balance laws. These ideas are then extended to the case when the ambient space is a Riemannian manifold. Pairwise interactions in the case of geodesically complete Riemannian ambient manifolds are defined by assuming that the interaction potential explicitly depends on the pairwise distances of particles. Postulating balance of energy and its invariance under arbitrary time-dependent spatial diffeomorphisms yields balance of linear momentum. It is seen that pairwise forces are directed along tangents to geodesics at their end points. One also obtains a discrete version of the Doyle–Ericksen formula, which relates the magnitude of internal forces to the rate of change of the interatomic energy with respect to a discrete metric that is related to the background metric.
Coping with competing demands: interruption and the type A pattern.

Police dispatchers play a critical role in police effectiveness in screening complaints from citizens, deciding whether to send a patrol officer, and choosing which officer to send on calls. Numerous studies have indicated that policing is a high-stress occupation, and surveys of police officers have identified a variety of potential job stressors, including poor equipment, long hours and shift work, and role overload (Davidson & Veno, 1980; Kroes, 1976). Beyond general survey research with police officers, however, there has been little systematic study of the dispatch role per se. Moreover, researchers have not yet examined the objective demands of police dispatching or how objective demands interact with personal disposition in determining job stress. The present investigation was conducted toward these ends. Specifically, this study examined the effects of externally imposed interruption and the Type A pattern on role overload stress. Role overload, defined as having too much to do in the time available (Kahn, Wolfe, Quinn, Shock, & Rosenthal, 1964), has important implications for employee health and quality of work. Previous research in organizational settings has demonstrated a significant relation between load and heavy smoking, elevated serum cholesterol, hypertension, and increased heart rate (Caplan & Jones, 1975; Cobb & Rose, 1973; French & Caplan, 1972). Because each of these factors is associ
Members of the WNT signaling pathways are widely expressed in mouse ovaries, oocytes, and cleavage stage embryos

The mammalian oocyte‐to‐embryo transition, characterized by a period of transcriptional silence, is dependent on maternal RNAs and proteins produced during the growth phase of the oocyte. Signaling pathways control timely transcription and translation of RNA, as well as post‐translational modification of proteins. The WNT/β‐catenin pathway is clearly not active during preimplantation embryo development. However, alternative Wnt signaling pathways may play a role during early embryo development. This study describes the extensive expression, at the transcript and protein level, of receptors, ligands, and intracellular molecules known to play a role in WNT signaling, as well as those known to negatively regulate the canonical WNT/β‐catenin pathway in developing oocytes and preimplantation embryos. This expression of a wide array of molecules involved in WNT signaling suggests that the alternative WNT pathways may be active during oogenesis and the oocyte‐to‐embryo transition. Developmental Dynamics 237:1099–1111, 2008. © 2008 Wiley‐Liss, Inc.
In search of models of pharmacoresistant epilepsy

Clinically available anticonvulsant drugs fail to control seizures in approximately 30% of epileptic patients. If hippocampal sclerosis is combined with focal dysplasia or similar developmental alterations, the likelihood of incomplete seizure control may reach >90%. Because only a minority of epilepsy patients benefit from epilepsy surgery, we need more research into the mechanisms of drug refractoriness. In this review we analyze different approaches to study pharmacoresistance and underlying mechanisms using in vitro models. Epileptiform discharges after prolonged application of low Mg2+ artificial cerebrospinal fluid (ACSF) or 4‐aminopyridine (4‐AP), or combined application of these convulsants with bicuculline in acute hippocampal–entorhinal cortex slices reveal pharmacoresistance and point to loss of γ‐aminobutyric acid (GABA)ergic function, in part due to reduced delivery of GABA from presynaptic terminals. Interestingly, epileptiform activity in immature tissue (organotypic hippocampal slice cultures and acute intact hippocampus) is immediately resistant to available antiepileptic drugs, and preliminary evidence points to a role of alterations in Cl− homeostasis. Seizure‐like events can also be induced in dissected tissues from human epileptic patients. Future research on human tissue may provide useful information for understanding the mechanisms underlying pharmacoresistance.
Compton Camera and Prompt Gamma Ray Timing: Two Methods for In Vivo Range Assessment in Proton Therapy

Proton beams are promising means for treating tumors. Such charged particles stop at a defined depth, where the ionization density is maximum. As the dose deposit beyond this distal edge is very low, proton therapy minimizes the damage to normal tissue compared to photon therapy. Nevertheless, inherent range uncertainties cast doubts on the irradiation of tumors close to organs at risk and lead to the application of conservative safety margins. This constrains significantly the potential benefits of protons over photons. In this context, several research groups are developing experimental tools for range verification based on the detection of prompt gammas, a nuclear by-product of the proton irradiation. At OncoRay and Helmholtz-Zentrum Dresden-Rossendorf, detector components have been characterized in realistic radiation environments as a step toward a clinical Compton camera. On the one hand, corresponding experimental methods and results obtained during the ENTERVISION training network are reviewed. On the other hand, a novel method based on timing spectroscopy has been proposed as an alternative to collimated imaging systems. The first tests of the timing method at a clinical proton accelerator are summarized, its applicability in a clinical environment for challenging the current safety margins is assessed, and the factors limiting its precision are discussed.
VASCULAR CALCIFICATION IN PATIENTS WITH KIDNEY DISEASE: Animal Models—What They Can Tell Us about Vascular Calcification in CKD

The development of cardiovascular calcifications in chronic kidney disease (CKD) patients involves multiple risk factors with additive effects. However, a number of questions concerning cardiovascular calcifications in CKD patients remain unanswered at present due to lack of clinical data or due to the impossibility of conducting clinical trials to investigate these issues. In this review, we discuss how animal models could help us understand better the pathophysiology and management of calcifying cardiovascular complications associated with CKD.
High temperature heat pump operational experience as a retrofit technology in domestic sector

This paper presents operational experience of high temperature heat pump in domestic building as a retrofit technology where it displaced existing gas boiler without any modification/replacement to existing controller or radiators in the house. Heat pump was integrated with 600l thermal storage where their performance was measured for five months from November 2014 to April 2015. During five months, performance under different settings such as direct mode, storage mode and combined mode operation were analysed. Operational experience shows limitation and issues of heat pump, house heat loss/insulation and sizing of thermal storage. More details about heating demand, COP, power consumption fluctuation and storage mode performance etc., have been presented in details. This operational analysis on heat pump would give information to installer, designer and government organization regarding field trial of heat pump, design consideration and proper sizing and selection of heat pump and thermal storage as a means of demand side management technology for domestic retrofit application.
Day-to-Day Variation of Insulin Requirements of Patients With Type 2 Diabetes and End-Stage Renal Disease Undergoing Maintenance Hemodialysis

OBJECTIVE To evaluate day-to-day variations of insulin needs in type 2 diabetic patients with end-stage renal disease (ESRD) on maintenance hemodialysis. RESEARCH DESIGN AND METHODS We developed a 24-h euglycemic clamp in patients who received an average of 2,200 calories in a standardized three-meal and two-snack regimen per day, adjusted to body size and sex. Intravenous insulin was adjusted every 30 min to achieve 5.5 ± 1.1 mmol/l glycemia over 24 h prehemodialysis, during hemodialysis session, and 24 h posthemodialysis in 10 type 2 diabetic patients, aged 55.7 ± 8.7 years with 11.9 ± 4.5 years diabetes duration, undergoing maintenance hemodialysis for 2.3 ± 2.3 years. Insulin requirements were derived from the dose of insulin administered to maintain euglycemia per period of time and day-to-day comparisons performed. RESULTS Mean capillary glycemia was 5.5 ± 0.3 mmol/l prehemodialysis and 5.3 ± 0.2 mmol/l posthemodialysis (P = 0.39). Pre- and posthemodialysis areas under the glucose curve were comparable. This was achieved by infusing 23.6 ± 7.7 IU/24 h prehemodialysis vs. 19.9 ± 4.9 IU/24 h posthemodialysis, indicating a 15.3% decrease posthemodialysis (P = 0.09). Basal insulin needs decreased from 0.4 ± 0.1/h prehemodialysis to 0.3 ± 0.1/h posthemodialysis (P = 0.01). Total boluses were decreased by 2.2 ± 3.1 IU (P = 0.15). Changes in blood urea did not correlate with changes in insulin needs (r = 0.1, P = 0.79). CONCLUSIONS The present study has demonstrated a significant 25% reduction in basal insulin requirements the day after dialysis compared with the day before. No significant change in boluses was observed, and overall the reduction of total insulin requirements was −15% equivalent to −4 IU/day posthemodialysis of marginal statistical significance.
Supporting Information for Quantifying the benefits of vehicle pooling with shareability networks

The data set contains origin-destination data of all 172 million trips with passengers of all 13,586 taxicabs in New York during the calendar year of 2011. Each vehicle is associated with a license, a so-called medallion, which is synonymously used as a name for the vehicles. These medallion taxis are the only vehicles in the city permitted to pick up passengers in response to a street hail. A medallion may be purchased from the City at infrequent auctions, or from another medallion owner. Because of their high prices medallions and most cabs are owned by investment companies and are leased to drivers. There are 39,437 unique driver IDs in the data set, which corresponds to 2.9 drivers per medallion on average. Note that we unfortunately do not have explicit information on the number of passengers per vehicle, however, following the data reported by [1], that the average daily number of passengers served by NY taxis is 600,000, with 450,000 trips on average, the average number of passengers per trip is around 1.3. The data set contains a number of fields from which we use the following: medallion ID, origin time, destination time, origin longitude, origin latitude, destination longitude, destination latitude. Times are accurate to the second, positional information has been collected via Global Positioning System (GPS) technology by the data provider. Out of our control are possible biases due to urban canyons which might have slightly distorted the GPS locations during the collection process [2]. All IDs are given in anonymized form, origin and destination values refer to the origins and destinations of trips, respectively. For creating the street network of Manhattan we used data from openstreetmap.org. We filtered the streets of Manhattan, selecting only the following road classes: primary, secondary, tertiary, residential, unclassified, road, living street. Several other classes were deliberately left
Adaptive System Identification in the Short-Time Fourier Transform Domain Using Cross-Multiplicative Transfer Function Approximation

In this paper, we introduce cross-multiplicative transfer function (CMTF) approximation for modeling linear systems in the short-time Fourier transform (STFT) domain. We assume that the transfer function can be represented by cross-multiplicative terms between distinct subbands. We investigate the influence of cross-terms on a system identifier implemented in the STFT domain and derive analytical relations between the noise level, data length, and number of cross-multiplicative terms, which are useful for system identification. As more data becomes available or as the noise level decreases, additional cross-terms should be considered and estimated to attain the minimal mean-square error (mse). A substantial improvement in performance is then achieved over the conventional multiplicative transfer function (MTF) approximation. Furthermore, we derive explicit expressions for the transient and steady-state mse performances obtained by adaptively estimating the cross-terms. As more cross-terms are estimated, a lower steady-state mse is achieved, but the algorithm then suffers from slower convergence. Experimental results validate the theoretical derivations and demonstrate the effectiveness of the proposed approach as applied to acoustic echo cancellation.
Brainstem Dysfunction Is Provoked by a Less Pronounced Hypoglycemic Stimulus in Diabetic BB Rats

Recent studies suggest that moderate hypoglycemia impairs brainstem function in normal humans and rats. To examine whether diabetes alters this response, simultaneous auditory-evoked potentials were recorded directly from the inferior colliculus (IC) and from the brainstem before and after controlled hypoglycemia (clamp) in awake insulin-dependent diabetic BB/Wor rats. Hyperglycemic diabetic animals were studied either during hyperinsulinemic euglycemia (5.6 mmol/l, n = 4) or mild hypoglycemia (3.5 mmol/l, n = 9). Nondiabetic controls were also studied at 3.5 mmol/l (n = 7) and at 2.8 mmol/l (n = 6). Brainstem function was not affected during euglycemia in diabetic rats. However, when plasma glucose was lowered to 3.5 mmol/l, the diabetic rats showed a 10% delay in IC evoked potential (ICEP) latency, whereas nondiabetic animals did not. This occurred despite similar counterregulatory hormones in both groups. The brainstem auditory-evoked potential (BAEP) localized the defect in the diabetic group to an area in or near the IC. When glucose levels were lowered to 2.8 mmol/l, however, brain function was impaired in nondiabetic rats as well. Again the defect was restricted to an area in or near the IC. We conclude that mild hypoglycemia causes a functional impairment in the IC region of the brainstem in both nondiabetic and diabetic rats. However, in the diabetic rats, this alteration occurs after a less pronounced hypoglycemic stimulus. Our findings suggest that chronic hyperglycemia leads to metabolic adaptions that render the diabetic brain more susceptible to mild hypoglycemia.
Increased consumption but not operant self-administration of ethanol in mice lacking the RIIbeta subunit of protein kinase A.

BACKGROUND Accumulating evidence indicates that adenosine monophosphate (cAMP)-dependent protein kinase A (PKA) is involved in the neurobiological responses to ethanol. Previous reports indicate that mice lacking the RIIbeta subunit of PKA (RIIbeta(-/-)) voluntarily consume more ethanol than wild-type controls (RIIbeta(+/+)) using 2-bottle testing procedures. Although such procedures primarily measure consummatory behavior, operant self-administration procedures allow analysis of consummatory as well as appetitive or "ethanol-seeking" behavior (i.e., lever pressing is required to gain access to the ethanol solution). Therefore, we determined whether the high ethanol consumption characteristic of RIIbeta(-/-) mice would be complemented by increased appetitive ethanol-seeking behavior in an operant paradigm. METHODS RIIbeta(-/-) (n=8) and RIIbeta(+/+) (n=8) mice were initially sucrose-faded until they were lever responding for nonsweetened ethanol (10, 14, and 18%). Following the self-administration testing, RIIbeta(+/+) and RIIbeta(-/-) mice were given access to 2 bottles, one containing water and the other ethanol to replicate the voluntary ethanol drinking data previously from our laboratory. Finally, immediately after voluntary consumption all mice were again tested for self-administration of 10% ethanol. Alterations in the reinforcement schedule were also explored as RIIbeta(+/+) and RIIbeta(-/-) mice were tested for self-administration of 10% ethanol at FR-3 and FR-5 schedules. RESULTS The RIIbeta(-/-) mice displayed lower operant responding for ethanol and food reinforcement compared with RIIbeta(+/+) controls. However, this effect was driven by a significant increase in lever responses made by female RIIbeta(+/+) mice. When the excessive lever responses of the female RIIbeta(+/+) mice are accounted for, the RIIbeta(-/-) mice show ethanol lever responses comparable to controls. Following operant self-administration testing, RIIbeta(-/-) mice of both sexes consumed more ethanol solution compared with RIIbeta(+/+) mice during 2-bottle testing. CONCLUSIONS Increased ingestion of ethanol by RIIbeta(-/-) mice is likely the result of altered PKA activity within neuronal pathways that control ethanol-consummatory behaviors. Conversely, the RIIbeta subunit of PKA appears not to play a critical role in neuronal pathways that regulate appetitive behaviors directed at obtaining ethanol. Finally, increased operant self-administration of food and ethanol by female wild-type mice was absent in female RIIbeta(-/-) mice, suggesting that normal PKA signaling may be part of a general, and sex-dependent, mechanism involved with reinforcement-seeking behavior.
Genetic architecture of fitness and nonfitness traits: empirical patterns and development of ideas

Comparative studies of the genetic architecture of different types of traits were initially prompted by the expectation that traits under strong directional selection (fitness traits) should have lower levels of genetic variability than those mainly under weak stabilizing selection (nonfitness traits). Hence, early comparative studies revealing lower heritabilities of fitness than nonfitness traits were first framed in terms of giving empirical support for this prediction, but subsequent treatments have effectively reversed this view. Fitness traits seem to have higher levels of additive genetic variance than nonfitness traits — an observation that has been explained in terms of the larger number loci influencing fitness as compared to nonfitness traits. This hypothesis about the larger functional architecture of fitness than nonfitness traits is supported by their higher mutational variability, which is hard to reconcile without evoking capture of mutational variability over many loci. The lower heritabilities of fitness than nonfitness traits, despite the higher additive genetic variance of the former, occur because of their higher residual variances. Recent comparative studies of dominance contributions for different types of traits, together with theoretical predictions and a large body of indirect evidence, suggest an important role of dominance variance in determining levels of residual variance for fitness-traits. The role of epistasis should not be discounted either, since a large number of loci increases the potential for epistatic interactions, and epistasis is strongly implicated in hybrid breakdown.
Alcohol consumption among the elderly in a general population, Erie County, New York.

OBJECTIVES Relatively few studies of drinking among the elderly have been completed despite the growing proportional representation of the elderly in the US population. This study sought to estimate the prevalence of and to observe whether active or health-oriented lifestyles are associated with heavy drinking among the elderly. METHODS Random-digit dialing telephone interviews were conducted with 2325 Erie County, New York, general population residents aged 60 years or older. RESULTS The prevalence of heavy drinking was 6%. Adjusted analyses showed positive associations between heavy drinking and being male, having suburban residency, and currently using cigarettes. Negative relationships were observed between heavy drinking and socioeconomic status, rural residency, and degree of health orientation. Age and level of active lifestyle were not significant contributors to the model. CONCLUSIONS Of the studied variables, health orientation offers the greatest opportunity to address heavy drinking among the elderly.
Intra-Arterial Pressure During Arm Weightlifting Exercise in Cardiac Patients

This study investigated the circulatory response to double-arm weightlifting exercise and compared the responses during free weight and machine equipment weightlifting in eight patients (mean age = 57.6±10 years) with well-documented coronary artery disease. Subjects performed bench press and overhead press exercises at 40 and 60% of 1 repetition maximum using both the free weights and machine equipment. Intra-arterial pressure was measured in the subclavian artery using a Millar catheter-tip pressure trandsucer. Arterial pressures rose in parallel with both modes of lifting (free weight and machine equipment), while heart rate did not increase substantially. Mean peak systolic (169 to 197 mmHg) and diastolic (95 to 119 mmHg) pressures recorded during the final repetitions of each weightlifting set did not, however, exceed values considered to be acceptable for dynamic exercise. Individual subjects recorded diastolic pressures as high as 150 mmHg during one or more of the weightlifting exercises, and individual mean arterial pressures reached values as high as 181 mmHg during overhead press machine equipment exercise at 60% of 1RM. While these high arterial pressures associated with weightlifting exercise increased myocardial oxygen demand (RPP=9643 to 15290), the increase in diastolic pressure may have augmented oxygen supply (DPTI=3448 to 3926