Miracle-dz/UniFAR-FTUs huggingface dataset:
HER-2/neu Oncogene Amplification by Chromogenic in situ Hybridization in 130 Breast Cancers Using Tissue Microarray and Clinical Follow-up Studies

Determining of HER-2/neu oncogene amplification has become clinically important for managing breast cancer. Fluorescent in situ hybridization (FISH) and immunohistochemistry (IHC) are currently regarded as the standard methods. Chromogenic in situ hybridization (CISH) was investigated as a new modification with an accurate, sensitive technique. From 1998 to 2002, using CISH and IHC, the amplification and protein expression of the HER-2/neu oncogene were examined using paraffin sections in 130 breast carcinomas and to determine the prognostic role of HER-2/neu for outcome after a follow-up of 24-64 months. Amplifications by CISH and overexpression by IHC were observed in 28 (22%) and 27 cases (20.8%), respectively. Of the 104 patients, 20 patients (19.2%) with amplification had a shorter disease-free interval (34.9 months vs. 38.0 months in controls) (p=0.372). 15 patients (14.4%) had a disease recurrence, but there is no significant difference between 3 patients amplifying the oncogene and 12 patients without oncogene (20.6 months vs. 19.6 months) (p=0.862). 6 patients (5.8%) of these died. CISH is a useful alternative, particularly for confirming the IHC results. There is no relationship between the early recurrence and the HER-2/neu positive group, but lymph node status was statistically significant.
ulti-voxel patterns of visual category representation during pisodic encoding are predictive of subsequent memory rice

Successful encoding of episodic memories is thought to depend on contributions from prefrontal and temporal lobe structures. Neural processes that contribute to successful encoding have been extensively explored through univariate analyses of neuroimaging data that compare mean activity levels elicited during the encoding of events that are subsequently remembered vs. those subsequently forgotten. Here, we applied pattern classification to fMRI data to assess the degree to which distributed patterns of activity within prefrontal and temporal lobe structures elicited during the encoding of word–image pairs were diagnostic of the visual category (Face or Scene) of the encoded image. We then assessed whether representation of category information was predictive of subsequent memory. Classification analyses indicated that temporal lobe structures contained information robustly diagnostic of visual category. Information in prefrontal cortex was less diagnostic of visual category, but was nonetheless associated with highly reliable classifier-based evidence for category representation. Critically, trials associated with greater classifier-based estimates of category representation in temporal and prefrontal regions were associated with a higher probability of subsequent remembering. Finally, consideration of trial-by-trial variance in classifier-based measures of category representation revealed positive correlations between prefrontal and temporal lobe representations, with the strength of these correlations varying as a function of the category of image being encoded. Together, these results indicate that multi-voxel representations of encoded information can provide unique insights into how visual experiences are transformed into episodic memories.
Integrative Neuroscience Review Article Spatial Cognition, Body Representation and Affective Processes: the Role of Vestibular Information beyond Ocular Reflexes and Control of Posture

A growing number of studies in humans demonstrate the involvement of vestibular information in tasks that are seemingly remote from well-known functions such as space constancy or postural control. In this review article we point out three emerging streams of research highlighting the importance of vestibular input: (1) Spatial Cognition: Modulation of vestibular signals can induce specific changes in spatial cognitive tasks like mental imagery and the processing of numbers. This has been shown in studies manipulating body orientation (changing the input from the otoliths), body rotation (changing the input from the semicircular canals), in clinical findings with vestibular patients, and in studies carried out in microgravity. There is also an effect in the reverse direction; top-down processes can affect perception of vestibular stimuli. (2) Body Representation: Numerous studies demonstrate that vestibular stimulation changes the representation of body parts, and sensitivity to tactile input or pain. Thus, the vestibular system plays an integral role in multisensory coordination of body representation. (3) Affective Processes and Disorders: Studies in psychiatric patients and patients with a vestibular disorder report a high comorbidity of vestibular dysfunctions and psychiatric symptoms. Recent studies investigated the beneficial effect of vestibular stimulation on psychiatric disorders, and how vestibular input can change mood and affect. These three emerging streams of research in vestibular science are—at least in part—associated with different neuronal core mechanisms. Spatial transformations draw on parietal areas, body representation is associated with somatosensory areas, and affective processes involve insular and cingulate cortices, all of which receive vestibular input. Even though a wide range of different vestibular cortical projection areas has been ascertained, their functionality still is scarcely understood.
Teaching Children How to Use Language to Solve Maths Problems

It is often claimed that working and talking with partners while carrying out maths activities is beneficial to students’ learning and the development of their mathematical understanding. However, observational research has shown that primary school children often do not work productively in group-based classroom activities, with the implication that they lack the necessary skills to manage their joint activity. The research we describe investigated these issues and also explored the role of the teacher in guiding the development of children’s skills in using language as a tool for reasoning. It involved an interventional teaching programme called Thinking Together, designed to enable children to talk and reason together effectively. The results obtained indicate that children can be enabled to use talk more effectively as a tool for reasoning; and that talk-based group activities can help the development of individuals’ mathematical reasoning, understanding and problem-solving. The results also encourage the view that the teacher of mathematics can play an important role in the development of children’s awareness and use of language as a tool for reasoning. We suggest some ways that this role can be carried out most effectively.
Relationship between masseter muscle activity and sleep-disordered breathing

The aim of this study was to investigate the possible association between sleep bruxism and sleep-disordered breathing. Twenty-six patients who snored (nine women and 17 men) participated in this study. All-night polysomnographic recordings, including masseter electromyography (EMG), were performed in all subjects. The frequency of masseter contraction (MC) episodes was measured. Masseter contraction episodes were classified under the phasic and tonic forms. The analyzed data indicated that the termination of apnea and hypopnea events are often accompanied with tonic MC. It is suggested that tonic MCs can be linked to apnea and hypopnea episodes.
On an Approach to Testing and Modeling Competence

E. L. Thorndike contributed significantly to the field of educational and psychological testing as well as more broadly to psychological studies in education. This article follows in his testing legacy. I address the escalating demand, across societal sectors, to measure individual and group competencies. In formulating an approach to measuring competence, I draw on measurement research I have done over my career; the Thorndike lecture is to be as much autobiographical as substantive and/or methodological. I present an approach to defining, measuring, and statistically modeling competency measurements. The article unpacks Hartig et al.'s (2008) definition of competence as a complex ability construct closely related to real-life-situated performance. The intent is to make the construct, competence, amenable to measurement. Once unpacked, criteria for building competence measurements are set forth and exemplified by research from business, military, and education sectors. Generalizability theory, a statistical theory for modeling and evaluating the dependability of competence scores, is applied to several of these examples. The article then pulls together the threads into a general competency measurement model and concludes by noting its limitations.
The Evolution of the Web and Implications for an Incremental Crawler

In this paper we study how to build an effective incremental crawler. The crawler selectively and incrementally updates its index and/or local collection of web pages, instead of periodically refreshing the collection in batch mode. The incremental crawler can improve the ``freshness'' of the collection significantly and bring in new pages in a more timely manner. We first present results from an experiment conducted on more than half million web pages over 4 months, to estimate how web pages evolve over time. Based on these experimental results, we compare various design choices for an incremental crawler and discuss their trade-offs. We propose an architecture for the incremental crawler, which combines the best design choices.
The relationship between apnoea hypopnoea index and Gensini score in patients with acute myocardial infarction undergoing emergency primary percutaneous coronary intervention.

BACKGROUND Sleep apnoea hypopnoea syndrome (SAHS) is characterised by repetitive nocturnal hypoxemia and has a high prevalence among patients with acute myocardial infarction (AMI). But there are few studies on patients with AMI undergoing emergency primary percutaneous coronary intervention (pPCI). In this study, we want to find the prevalence of SAHS among patients with AMI undergoing emergency pPCI and determine whether SAHS would worsen the condition among these people, and especially affect the damage degree of the coronary artery. METHODS Over four months, 95 patients admitted for the first time for AMI were observed. All of them had emergency primary PCIs. A total of 86 patients accepted the sleep study and were divided into four groups according to the apnoea hypopnoea index (AHI): SAHS was diagnosed when AHI ≥5/h and was defined as mild for AHI ≥5/h and <15/h, moderate for AHI ≥15/h and <30/h, and severe for AHI ≥30/h. On the contrary, the patients whose AHI <5/h were Non-SAHS. And the characteristics of the patients among these four groups were compared. According to the time of chest pain onset, the number of the patients between SAHS and non-SAHS, and patients' AHI during three intervals of one day were measured and compared; Makers including the sensitivity of serum troponin T (hs-TnT), creatine kinase isoenzyme MB (CK-MB), left ventricular ejection fraction (LVEF), pro-brain-type natriuretic peptide (pro-BNP), Gensini score and collateral vessels between the SAHS and non-SAHS were compared. And the relationships between the AHI of these patients and the markers were analysed. RESULTS Of the 86 patients studied, 65 had SAHS, representing a SAHS prevalence of 75.58% among patients with AMI undergoing emergency pPCI. There were significant differences in average ages, smoking and arrhythmia (P<0.05) between these four groups. There was no significant difference between AMI patients with or without SAHS regarding the day-night pattern. But there showed significant differences between SAHS and non-SAHS in Gensini score (P<0.05) and pro-BNP (P<0.05). Also, there were positive correlations between AHI and Gensini score (r=0.490, P<0.05) and pro-BNP (r=0.338, P<0.05). CONCLUSIONS Among patients with AMI undergoing emergency pPCI, there is a high prevalence of SAHS. There are also positive correlations between AHI and Gensini score, and pro-BNP. Therefore, guided by the results, should we conduct a routine screening to those patients normally and could we relieve the damage to the coronary artery by curing the SAHS?
Determinants of health‐seeking behaviour for schistosomiasis‐related symptoms in the context of integrating schistosomiasis control within the regular health services in Ghana

Morbidity control of schistosomiasis through integration within existing health care delivery systems is considered a potentially sustainable and cost‐effective approach. We conducted a questionnaire‐based field study in a Ghanaian village endemic for both urinary and intestinal schistosomiasis to determine whether infected individuals self‐reported to health centres or clinics and to identify factors that influenced their decision to seek health care. A total of 317 subjects were interviewed about having signs and symptoms suggestive of schistosomiasis: blood in urine, painful urination, blood in stool/bloody diarrhoea, abdominal pain, diarrhoea, swollen abdomen and fatigue within 1 month of the day of the interview. Fever (for malaria) was included as a disease of high debility for comparison. Around 70% with blood in urine or painful urination did not seek health care, whilst diarrhoea, blood in stool, abdominal pain and fever usually led to action (mainly self‐medication, with allopathic drugs being used four to five times more often than herbal treatment). On average 20% of schistosomiasis‐related signs and symptoms were reported to health facilities either as the first option or second and third alternative by some of those that self‐medicated. A few of those who visited a clinic or health centre as first option still self‐medicated afterwards. Children under 10 years and adults were more likely to seek health care than teenagers. Also, females were more likely to visit a health facility than males of the same age groups. Socio‐economic status and duration of symptoms did not appear to affect health‐seeking behaviour. ‘Do not have the money’ (43%) and ‘Not serious enough’ (41%) were the commonest reasons for not visiting a clinic, reported more frequently by lower and higher socio‐economic classes, respectively, for both urinary or intestinal schistosomiasis. The regular health service shows some potential in passive control of schistosomiasis as some, but far too few, people visit a health facility as first or second option.
Press-Party Parallelism and Polarization of News Media during an Election Campaign

The aim of this article is to examine press-party parallelism during the 2011 national elections in Turkey. The article reports findings from a content analysis of 9,127 news articles and editorial columns from fifteen newspapers regarding the trajectory of press-party parallelism over the course of the twelve-week national elections campaign period. We focus on two indicators of press-party parallelism: (1) respective “voice” given to the two leading parties, calculated as the ratio of news that quoted sources from the incumbent Adalet ve Kalkınma Partisi (AKP) to the leading opposition party Cumhuriyet Halk Partisi (CHP) and (2) news articles’ tones toward AKP and CHP. The newspapers that were content analyzed were first categorized into three groups based on survey data regarding the voting intentions of their readers: (1) a group of “conservative” newspapers whose readers intended to vote primarily for AKP, (2) a group of “mainstream broadsheets,” and (3) a group of “opposition” newspapers with a readership base intending to vote for CHP. The findings suggest that over the course of the election campaign, internal pluralism in both conservative and opposition papers declined in terms of voice given to respective parties and tone of news coverage.
Fostering the Growth of Beginners' Improvisational Skills: A study of dance teaching practices in the high school setting

This interpretive study was aimed at describing two teaching practices of improvisation as they naturally occurred in the context of a secondary school dance programme, over a complete academic year. It was framed by the following research questions: what objectives are made explicit by the teachers as they present and conduct improvisation situations? What teaching strategies are put forward to achieve these objectives? Data were gathered through participant observation and semi-structured interviews. Observation revealed a wide spectrum of improvisational opportunities to have been offered throughout the dance programme. Six learning objectives emerged from an inductive analysis of the data. These were learning to: 1) generate movement spontaneously; 2) concentrate; 3) be physically alert; 4) take responsibility for decision making; 5) relate to one another while moving; 6) observe movement. Five broad teaching strategies emerged to engage students to generate movement spontaneously. They were: 1)setting up the situation; 2) presenting the task; 3) providing the transition to execution; 4) guiding the task execution; and 5) revisiting the situation. These broad strategies, in turn, served as the most immediate context where teachers could simultaneously foster students' ability to generate movement spontaneously. Some of the other five learning objectives found lay a foundation for improvisation. Findings contribute to an increased awareness of the dynamics of an improvisational situation, and of the learning involved in the growth of beginners' improvisational skills. They also provide concrete examples of how opportunities to develop improvisational skills can be offered in the course of high school dance instruction.
Group analysis and the subject factor in functional magnetic resonance imaging: Analysis of fifty right‐handed healthy subjects in a semantic language task

Before considering a given fMRI paradigm as a valid clinical tool, one should first assess the reliability of functional responses across subjects by establishing a normative database and defining a reference activation map that identifies major brain regions involved in the task at hand. However, the definition of such a reference map can be hindered by inter‐individual functional variability. In this study, we analysed functional data obtained from 50 healthy subjects during a semantic language task to assess the influence of the number of subjects on the reference map and to characterise inter‐individual functional variability. We first compared different group analysis approaches and showed that the extent of the activated network depends not only on the choice of the analysis approach but also on the statistical threshold used and the number of subjects included. This analysis suggested that, while the RFX analysis is suitable to detect confidently true positive activations, the other group approaches are useful for exploratory investigations in small samples. The application of quantitative measures at the voxel and regional levels suggested that while ∼15–20 subjects were sufficient to reveal reliable and robust left hemisphere activations, >30 subjects were necessary for revealing more variable and weak right hemisphere ones. Finally, to visualise inter‐individual variability, we combined two similarity indices that assess the percentages of true positive and false negative voxels in individual activation patterns relative to the group map. We suggest that these measures can be used for the estimation of the degree of ‘normality’ of functional responses in brain‐damaged patients, where this question is often raised, and recommend the use of different quantifications to appreciate accurately the inter‐individual functional variability that can be incorporated in group maps. Hum Brain Mapp 2008. © 2007 Wiley‐Liss, Inc.
Iron deficiency anemia in Tarahumara women of reproductive-age in northern Mexico.

OBJECTIVE To determine the prevalence of iron deficiency anemia (IDA) among Tarahumara women of reproductive age. MATERIAL AND METHODS A cross-sectional survey was conducted in a representative sample of 481 women aged 12-49 years, residents of Guachochi Municipality, Chihuahua, from June to September 1998. The hemoglobin (Hb) level was measured in capillary blood using the Hemocue technique, and the serum ferritin level in capillary serum spotted on filter paper, in a sub-sample of women. Central tendency and dispersion measures were estimated; the Chi-squared test was used to test differences in proportions and ANOVA and Bonferroni's test for differences in means. RESULTS Prevalence of anemia (mean Hb +/- S.D.) was 16.1% (140 +/- 16 g/l) and 25.7% (129 +/- 12 g/l) for non-pregnant and pregnant women, respectively. Pregnant women in the 3rd trimester and those who were breast-feeding their children during the first 6 months after delivery had the highest prevalence of anemia (38.5% and 42.9%, respectively). Iron deficiency was responsible for most of the anemia found in this sample. CONCLUSIONS This study provides relevant information for the development of intervention programs to treat and prevent IDA in this ethnic group.
Systematic review of respiratory case definitions in metalworking fluid outbreaks.

BACKGROUND Since the mid-1990s, outbreaks of asthma and extrinsic allergic alveolitis (EAA) have been identified in workers exposed to metalworking fluids (MWFs). The cause of these outbreaks remains to be determined. AIMS To identify and review all previously published occupational lung disease case definitions and diagnostic criteria that have been utilized during MWF outbreak investigations. METHODS Respiratory outbreaks due to MWFs were identified by a systematic literature search for articles published between 1990 and October 2011. Investigations reporting the usage of disease case definitions or diagnostic criteria for respiratory disease were reviewed and summarized. RESULTS The literature search identified 35 papers relating to 27 outbreaks of respiratory disease in MWF-exposed workers. Fourteen case definitions for MWF-related respiratory disease were identified: seven for EAA, five for occupational asthma and one each for humidifier fever and industrial bronchitis. A single paper was identified where any comparison of different disease case definitions (for EAA) had been performed. CONCLUSIONS A range of case definitions and diagnostic criteria for MWF respiratory disease have been utilized in outbreak investigations, but the majority have been produced for individual outbreak investigations without previous validation. It may be difficult to compare the findings of future workplace studies without a more standardized approach to case identification and diagnosis.