Miracle-dz/UniFAR-FTUs huggingface dataset:
Ubii: Towards Seamless Interaction between Digital and Physical Worlds

We present Ubii (Ubiquitous interface and interaction), an interface system that aims to expand people's perception and interaction from the digital space to the physical world. The centralized user interface is broken into pieces woven in the domain environment. Augmented user interface is paired to the physical objects, where physical and digital presentations are displayed in the same context. The augmented interface and physical affordance respond as one control to provide seamless interaction. By connecting digital interface with physical objects, the system presents a nearby embodiment to afford users sense of awareness to interact with domain objects. Integrated on wearable devices as Google Glass, a less intrusive and more convenient interaction is afforded. Our research illustrates the great potential of direct mapping of interaction between digital interfaces and physical affordance by converging wearable devices and augmented reality (AR) technology.
Boroxol rings from diffraction data on vitreous boron trioxide

There has been a considerable debate about the nature of the short range atomic order in vitreous B2O3. Some authorities state that it is not possible to build a model of glassy boron oxide of the correct density containing a large number of six-membered rings which also fits experimental diffraction data, but recent computer simulations appear to overrule that view. To discover which view is correct I use empirical potential structure refinement (EPSR) on existing neutron and x-ray diffraction data to build two models of vitreous B2O3. One of these consists only of single boron and oxygen atoms arranged in a network to reproduce the diffraction data as closely as possible. This model has less than 10% of boron atoms in boroxol rings. The second model is made up of an equimolar mixture of B3O3 hexagonal ring ‘molecules’ and BO3 triangular molecules, with no free boron or oxygen atoms. This second model therefore has 75% of the boron atoms in boroxol rings. It is found that both models give closely similar diffraction patterns, suggesting that the diffraction data in this case are not sensitive to the number of boroxol rings present in the structure. This reinforces recent Raman, ab initio, and NMR claims that the percentage of boroxol rings in this material may be as high as 75%. The findings of this study probably explain why some interpretations based on different simulation techniques only find a small fraction of boroxol rings. The results also highlight the power of EPSR for the extraction of accurate atomistic representations of amorphous structures, provided adequate additional, non-scattering data (such as Raman and NMR in this case) are available.
Slurry jet erosion performance of high-velocity flame-sprayed nano mixed Ni-40Al2O3 coating in aggressive environment

Hydro turbine components are subjected to severe erosion especially during the rainy season in the Himalayan region. To protect the CA6NM turbine steel, an attempt has been made to develop the Ni-40Al2O3 composite coating using a high-velocity flame spray process. To lower the porosity, the coating was developed by mixing two different sizes (viz. micron and nano) of alumina (Al2O3) reinforcement with 60 wt. % Ni as the base powder. The characterization of the as-sprayed coating was done by scanning electron microscopy/energy dispersive X-ray spectroscopy, and PANalytical X-ray diffraction technique, whereas mechanical characterization was done for the evaluation of microhardness, bond strength, and surface roughness. The performance of the developed coating was compared with uncoated steel on slurry jet erosion test rig under accelerated conditions by varying the three parameters, viz. slurry concentration, erodent size, and impact velocity. Ni-40Al2O3 coating was found to be effective for minimizing the erosion rate in comparison with the uncoated steel. Scanning electron microscopy of eroded coatings mainly reveals the brittle type of signature on the coating.
Effects of cooling the pharyngeal mucosa after bipolar scissors tonsillectomy on postoperative pain

Abstract Conclusion: Bipolar scissors tonsillectomy followed by cooling down the pharyngeal mucosa has advantages in terms of postoperative pain and intraoperative blood loss compared with cold dissection. Objectives: The purpose of this study was to compare the postoperative pain between bipolar scissors tonsillectomy followed by cooling the pharyngeal mucosa and a traditional cold dissection. Methods: A total of 189 patients aged more than 16 years were operated due to habitual tonsillitis, obstructive sleep apnea syndrome, and IgA nephropathy. Of these, 79 patients were operated using bipolar scissors followed by cooling the pharyngeal mucosa with 4°C saline for 10 min just after the removal of tonsils. The other 110 patients underwent cold dissection tonsillectomy. Outcome measures were intraoperative blood loss, operative time, postoperative pain evaluated on a visual analog scale, and postoperative secondary hemorrhage. Results: Significantly lower levels of intraoperative blood loss and less postoperative pain were obtained in bipolar scissors tonsillectomy followed by cooling the pharyngeal mucosa compared with cold dissection. Postoperative hemorrhage needing hemostatic surgery occurred in 2 of 79 patients who underwent bipolar scissors tonsillectomy with cooling, while it occurred in 1 of 110 patients after cold dissection. However, the difference was not statistically significant.
Plasma cell hepatitis in hepatitis C virus patients post–liver transplantation: Case‐control study showing poor outcome and predictive features in the liver explant

Plasma cell hepatitis (PCH) is characterized by plasma cell infiltration seen in allografts of patients who underwent liver transplantation (LT) for conditions other than autoimmune hepatitis. We identified 40 PCH patients who underwent LT for hepatitis C virus (HCV) by searching our pathology database (1994–2006) for the keywords liver allograft, lymphoplasmacytic, and plasma cell(s). We selected 2 control patients who received LT for HCV for each PCH case. The control patients were matched according to date of LT and availability of biopsy material at the time interval to development of PCH in PCH patients. Explant and post‐LT biopsy slides were blindly reviewed by 2 liver pathologists and the severity of the plasma cell infiltrate was scored. A score of 3 (plasma cells composing >30% of the infiltrate) defined PCH in allograft biopsies. Five random areas of dense inflammation were also examined in explant livers and the highest score was used. Poor outcome was defined as death or advanced fibrosis (stage ≥ 4 of 6). We found that PCH patients were more likely to have worse outcomes than control patients (65% versus 40%, P < 0.01), including increased mortality (50% versus 30%, P < 0.05). Kaplan‐Meier survival analysis showed significantly worse survival for PCH patients from 4 to 10 years post‐LT (P < 0.05). Explants from 40% of PCH patients had a score of 3 compared to 18% of control patients (P < 0.01). We found that the development of PCH is associated with poor outcome in patients undergoing LT for HCV. The association of significant plasma cell infiltrates in native livers of HCV patients developing PCH suggests that some patients may have a predisposition to developing PCH. Liver Transpl 15:1826–1833, 2009. © 2009 AASLD.
Accumulation of Laminin Monomers in Drosophila Glia Leads to Glial Endoplasmic Reticulum Stress and Disrupted Larval Locomotion

The nervous system is surrounded by an extracellular matrix composed of large glycoproteins, including perlecan, collagens, and laminins. Glial cells in many organisms secrete laminin, a large heterotrimeric protein consisting of an α, β, and γ subunit. Prior studies have found that loss of laminin subunits from vertebrate Schwann cells causes loss of myelination and neuropathies, results attributed to loss of laminin-receptor signaling. We demonstrate that loss of the laminin γ subunit (LanB2) in the peripheral glia of Drosophila melanogaster results in the disruption of glial morphology due to disruption of laminin secretion. Specifically, knockdown of LanB2 in peripheral glia results in accumulation of the β subunit (LanB1), leading to distended endoplasmic reticulum (ER), ER stress, and glial swelling. The physiological consequences of disruption of laminin secretion in glia included decreased larval locomotion and ultimately lethality. Loss of the γ subunit from wrapping glia resulted in a disruption in the glial ensheathment of axons but surprisingly did not affect animal locomotion. We found that Tango1, a protein thought to exclusively mediate collagen secretion, is also important for laminin secretion in glia via a collagen-independent mechanism. However loss of secretion of the laminin trimer does not disrupt animal locomotion. Rather, it is the loss of one subunit that leads to deleterious consequences through the accumulation of the remaining subunits. SIGNIFICANCE STATEMENT This research presents a new perspective on how mutations in the extracellular matrix protein laminin cause severe consequences in glial wrapping and function. Glial-specific loss of the β or γ laminin subunit disrupted glia morphology and led to ER expansion and stress due to retention of other subunits. The retention of the unpaired laminin subunit was key to the glial disruption as loss of Tango1 blocked secretion of the complete laminin trimer but did not lead to glial or locomotion defects. The effects were observed in the perineurial glia that envelope the peripheral and central nervous systems, providing evidence for the importance of this class of glia in supporting nervous system function.
Necrotizing soft tissue infections: delayed surgical treatment is associated with increased number of surgical debridements and morbidity.

BACKGROUND Early surgical treatment is crucial in the management of necrotizing soft tissue infections (NSTI), a severe, potentially life threatening, rapidly progressive infection. The purpose of this study was to determine the influence of surgical procedure timing on the number of surgical debridements required. METHODS A retrospective study including 47 patients with the diagnosis of NSTI admitted to a large academic hospital from December 2004 to December 2010 was conducted. Demographics, basic laboratories on admission, medical comorbidities, site of infection, and intraoperative culture results were compared between patients with early (≤12 hour) and late (>12 hour) surgical treatment. The x-y plot for the study population and linear regression analyses were used to define the time cut point. Outcomes included the total number of debridements, mortality, hospital length of stay, and complications. Adjustment for confounding factors was done with binary regression logistic model for categorical outcomes and analysis of covariants for continuous outcomes. RESULTS Overall mortality was 17.0%. The average number of surgical debridements in patients with delay surgical treatment >12 hours from the time of emergency department admission was significantly higher than those who had an operation within 12 hours after admission (7.4 ± 2.5 vs. 2.3 ± 1.2; p < 0.001). Delayed surgical debridement was associated with significantly higher mortality, higher incidence of septic shock and renal failure, and more surgical debridements than patients with early surgical debridements. After adjusting for possible confounding factors, the average number of surgical debridements and the presence of septic shock and acute renal failure were still significantly higher in patients in whom surgery was delayed >12 hours. CONCLUSION In patients with NSTI, a delay of surgical treatment of >12 hours is associated with an increased number of surgical debridements and higher incidence of septic shock and acute renal failure.
Nanooptics of Molecular-Shunted Plasmonic Nanojunctions

Gold nanoparticles are separated above a planar gold film by 1.1 nm thick self-assembled molecular monolayers of different conductivities. Incremental replacement of the nonconductive molecules with a chemically equivalent conductive version differing by only one atom produces a strong 50 nm blue-shift of the coupled plasmon. With modeling this gives a conductance of 0.17G0 per biphenyl-4,4′-dithiol molecule and a total conductance across the plasmonic junction of 30G0. Our approach provides a reliable tool quantifying the number of molecules in each plasmonic hotspot, here <200.
Supply Chain Choice on the Internet

Internet companies extensively use the practice of drop-shipping, where the wholesaler stocks and owns the inventory and ships products directly to customers at retailers request. Under the drop-shipping arrangement, the supply chain benefits from risk pooling because the inventory for multiple retailers is stocked at the same location, the wholesalers. Another more traditional channel alternative on the Internet is one in which retailers stock and own the inventory. These two supply chain structures, which predominate on the Internet, result in different inventory risk allocation, stocking decisions, and profits for channel members. Moreover, the two channel alternatives can be combined into a dual strategy whereby the retailer uses local inventory as a primary source and relies on drop-shipping as a backup. We model the dual strategy as a noncooperative game among the retailers and the wholesaler, analyze it, and obtain insights into the structural properties of the equilibrium solution to facilitate development of recommendations for practicing managers. Finally, we characterize situations in which each of three channels is preferable by specifying appropriate ranges of critical parameters, including demand variability, the number of retailers in the channel, wholesale prices, and transportation costs.
Updating relational data via SPARQL/update

Relational Databases are used in most current enterprise environments to store and manage data. The semantics of the data is not explicitly encoded in the relational model, but implicitly on the application level. Ontologies and Semantic Web technologies provide explicit semantics that allows data to be shared and reused across application, enterprise, and community boundaries. Converting all relational data to RDF is often not feasible, therefore we adopt an ontology-based access to relational databases. While existing approaches focus on read-only access, we present our approach OntoAccess that adds ontology-based write access to relational data. OntoAccess consists of the updateaware RDB to RDF mapping language R3M and algorithms for translating SPARQL/Update operations to SQL. This paper presents the mapping language, the translation algorithms, and a prototype implementation of OntoAccess.
Novel HIV-1 non-nucleoside reverse transcriptase inhibitors: a patent review (2011 – 2014)

Introduction: There is a continuous need for next-generation non-nucleoside RT inhibitors (NNRTIs) with different resistance profiles, improved safety, excellent tolerability, and favorable physicochemical properties. Areas covered: In this review we intend to narrate a general and cutting-edge overview of current state of NNRTI patents during the 2011 – 2014 (June) period and future perspectives. Particular focus is placed on the highlighting of some emerging medicinal chemistry principles and insights in the discovery and development of NNRTIs. Expert opinion: The development of effective NNRTIs is moving on from trial-and-error approaches to sophisticated subconscious strategies. Several newly emerging structure-based virtual screening methodologies (such as Monte Carlo free energy perturbation calculations) or new drug design insights, such as taking full use of the specific noncovalent reverse transcriptase/NNRTIs interactions, stereochemical diversity-oriented conformational restriction, novel strategies to enhance solubility and early absorption, distribution, metabolism, excretion, and toxicity (ADMET) assessment, will continue to evolve to complement the classical NNRTIs discovery approaches (structure-based core-refining and substituents-decorating).
Decannulation Following Tracheostomy for Prolonged Mechanical Ventilation

Background: We examined the process of decannulation following tracheostomy in patients transferred to a long-term acute care (LTAC) hospital for weaning from prolonged mechanical ventilation (PMV). Methods: A retrospective chart review of 135 patients. Results: Decannulation was successful in 35% of patients a median of 45 days (IQR, 32-76) following tracheostomy. Patients who failed decannulation had a tracheostomy tube placed earlier (14 days; IQR 11-18 vs. 18 days; IQR 14-30, P = .04) and had a shorter length of stay at the acute facility (20 days; IQR, 16-23 vs. 31 days; IQR, 24-45, P = .003) compared with patients who were decannulated. Length of stay and cost of care at the LTAC did not differ with decannulation status. At 3.5 years, 35% (47/135) of all patients and 62% (29/47) of decannulated patients were alive. Conclusions: Decannulation was achieved in 35% of patients transferred to an LTAC for weaning from prolonged mechanical ventilation.
Role of estrogen as initiator of daily LH surges in the ovariectomized rat.

The following studies were performed to determine whether the occurrence of daily LH surges in long-term ovariectomized rats requires an increment in circulating estradiol concentrations, and if so, to investigate the nature of the estrogen stimulus. On the 15th day after bilateral ovariectomy (day 0), estradiol benzoate (EB, 50 μg/rat SC in sesame oil), estradiol–17β in Silastic capsules implanted SC, or sesame oil was administered at 7:00 AM. Within 10 hr following EB treatment, circulating estrogen increased to approximately 1800 pg/mland then declined progressively during the next 4 days to 100 pg/ml. Following insertion of estradiolimplants, however, serum estradiol levels attained maxima of approximately 125 pg/ml within 1 hr anddecreased within 14 hr to 75 pg/ml, a level maintained until implant removal. Blood samples were withdrawn from unanesthetized rats by carotid cannula or by cardiac puncture at 6:00 AM on day 0 and at 12:30 and 5:00 PM on days 0–4. Within 5½ hr following administration of EB.
Cadmium phytoextraction from loam soil in tropical southern China by Sorghum bicolor

ABSTRACT The cadmium (Cd) uptake characteristics by Sorghum bicolor cv. Nengsi 2# and Cowley from the acidic sandy loam soil (pH = 6.1) during the entire growth period (100 days) were investigated in pot outdoors in a tropical district of southern China, Hainan Island. The Cd-spiked levels in soil were set as 3 and 15 mg/kg. Correspondingly, the available Cd levels in soil extracted by Mehlich III solution were 2.71 and 9.41 mg/kg, respectively. Basically, two varieties in a full growth period (100 days) did not show a significant difference in their growth and Cd uptake. Under high Cd stress, the plant growth was inhibited and its biomass weight and height decreased by 38.7–51.5% and 27.6–28.5%, respectively. However, S. bicolor showed higher bioaccumulation capability of Cd from soil to plant [bioconcentration factor (BCF)>4], and higher transfer capability of Cd from roots to shoots [translocation factor (TF)>1] under high Cd stress; Cd contents in the roots, stems, and leaves of S. bicolor reached 43.79–46.07, 63.28–70.60, and 63.10–66.06 mg/kg, respectively. S. bicolor exhibited the potential phytoextraction capability for low or moderate Cd-contamination in acidic sandy loam soil.
The effect of postings information on searching behaviour A statistical approach to designing search filters to find systematic reviews : objectivity enhances accuracy

Search filters are increasingly used to search medical databases to identify specific topics or study designs. In particular, search filters have been designed to help health-care professionals identify systematic reviews of the effectiveness of health interventions. Identifying systematic reviews in databases such as MEDLINE is problematic and research has previously been undertaken into methods to design search filters that retrieve systematic reviews effectively. The aim of this study was to improve previously developed methods to derive a more objective search strategy to identify systematic reviews in MEDLINE. A ‘quasi-gold standard’ collection of known systematic reviews was identified. A frequency analysis of words within a subset of the ‘quasi-gold standard’ was undertaken followed by a statistical analysis of the most frequently occurring words. This analysis determined which terms would best distinguish between systematic reviews, non-systematic reviews and non-reviews. The performance of the best models was tested on the remaining subset of ‘quasi-gold standard’ records and then using the OVID interface to MEDLINE. The best model had a sensitivity of 73.4% for systematic reviews in the test set and 84.2% when used with the validation set. The best model had a specificity of 98.3% in the test set and 93% in the validation set. When tested on the same ‘quasi-gold standard’ using OVID MEDLINE the model showed 100% sensitivity and 4.4% precision. The number of times a term occurs in a record adds discriminatory power to the search strategy. Apparently highly relevant terms chosen subjectively do not perform as well as those derived by a statistical approach. Some search terms may not immediately seem useful in identifying systematic reviews, but when used in combination with other terms they prove to be highly discriminating. The best performing filters were tested on the OVID interface, but without frequency and term weightings. Their performance was also compared to previously published filters. One of the strategies was found to perform better with respect to sensitivity than previously published filters, although with lower precision.
Synthesis of networks on chips for 3D systems on chips

Three-dimensional stacking of silicon layers is emerging as a promising solution to handle the design complexity and heterogeneity of Systems on Chips (SoCs). Networks on Chips (NoCs) are necessary to efficiently handle the 3D interconnect complexity. Designing power efficient NoCs for 3D SoCs that satisfy the application performance requirements, while satisfying the 3D technology constraints is a big challenge. In this work, we address this problem and present a synthesis approach for designing power-performance efficient 3D NoCs. We present methods to determine the best topology, compute paths and perform placement of the NoC components in each 3D layer. We perform experiments on varied, realistic SoC benchmarks to validate the methods and also perform a comparative study of the resulting 3D NoC designs with 3D optimized mesh topologies. The NoCs designed by our synthesis method results in large interconnect power reduction (average of 38%) and latency reduction (average of 25%) when compared to traditional NoC designs.