Miracle-dz/UniFAR-FTUs huggingface dataset:
Allogeneic transplantation for advanced acute myeloid leukemia: The value of complete remission

Patients with acute myeloid leukemia (AML) without complete remission (CR) or in first relapse (Rel1) can have extended leukemia control and survival after allogeneic hematopoietic cell transplantation (HCT). For patients in Rel1 or primary induction failure (PIF), transplantation versus treatment to achieve a second CR (CR2) and subsequent HCT might yield similar outcomes, but available comparative data are scarce.
Passive Particle Jamming and Its Stiffening of Soft Robotic Grippers

The compliance of soft grippers contributes to their great superiority over rigid grippers in grasping irregularly shaped objects and forming soft contact with environments. Due to a relatively small pressure, soft grippers lack the stiffness required for wider applications. Particle jamming has been frequently reported as a means of stiffness control. Unlike previous research using vacuum for particle jamming, this paper proposes a novel passive particle jamming principle that does not need any vacuum power or other control means. The proposed method is by simply patching a silicone rubber soft actuator and a pack (made of strain-limiting membrane) of particles to form an integral gripping finger. The inflation of the soft actuator applies a pressure to the particle pack causing particles inside it to jam. A larger squeezing pressure will result in tighter particle jamming, thus increasing the stiffness of the finger. The stiffness of the finger is controllable as it is proportional to the actuator's air pressure, which has been verified by experiments in this research. The stiffness can increase more than six fold when air pressure changes from 20 to 80 kPa in the experimental studies. The reported discovery may enhance the capabilities of soft robotic grippers so that more robotic picking operations could be performed by soft grippers.
Systematic Review of the Association Between Physical Fitness and Musculoskeletal Injury Risk: Part 2—Muscular Endurance and Muscular Strength

Abstract de la Motte, SJ, Gribbin, TC, Lisman, P, Murphy, K, and Deuster, PA. A systematic review of the association between physical fitness and musculoskeletal injury risk: part 2—muscular endurance and muscular strength. J Strength Cond Res 31(11): 3218–3234, 2017—This is a systematic review and evaluation of the current evidence on the association between both muscular endurance (ME) and muscular strength (MS) and musculoskeletal injury (MSK-I) risk in military and civilian populations. MEDLINE, EBSCO, EMBASE, and the Defense Technical Information Center were searched for original studies published from 1970 through 2015 which examined associations between physical fitness (ME and MS) and MSK-I in military or civilian populations. Methodological quality and strength of the evidence were determined following criteria adapted from previously published systematic reviews. Forty-five of 4,229 citations met our inclusion criteria. Although results for some tests did vary by sex, taken together, our primary findings indicate there is (a) a strong evidence that poor performance in a push-up test is associated with MSK-I risk; (b) moderate evidence that poor performance in sit-up test is associated with MSK-I risk; (c) moderate evidence that isokinetic ankle and knee flexion strength, and isometric strength assessments at the back, elbow, or knee are associated with MSK-I risk; and (d) limited evidence that poor performance in a pull-up test and isotonic assessments of muscular strength are associated with MSK-I. Several measures of ME/MS are moderately or strongly associated with risk of MSK-I, but additional research is needed to identify and recommend specific assessments of ME/MS that predict MSK-I in both men and women. Future studies should also consider measures of ME and MS as a function of upper body, lower body, and core strength, and their potential association with specific, rather than general, MSK-I.
Accumulation and distribution characteristics of biomass and nitrogen in bitter gourd (Momordica charantia L.) under different fertilization strategies.

BACKGROUND The elemental uptake and allocation patterns of crops create insight for nutrient management. Two-year field experiments were conducted to determine the growth and nitrogen (N) uptake patterns of bitter gourd and to evaluate different N management strategies. Two N practices during the nursery stage, namely the conventional fertilizer method (Scon) and the controlled-release fertilizer management method (Scrf), combined with three N management strategies after transplanting, namely zero N fertilizer application (Nno), the conventional strategy (Ncon) and the systematic N management strategy (Nopt), were assessed. RESULTS Averaged over two years, the Scrf-Nopt treatment performed best, producing 33.1 t ha-1 fruit yield with 310 kg N ha-1 , indicating that the yield was 22.6% greater by using 18.8% less fertilizer N than in the Scon-Ncon treatment. The Scrf-Nopt treatment facilitated plant growth by accumulating 20.0% more total dry weight and prioritized its allocation to productive organs (57.2%), while the Scon-Ncon strategy was biased toward leaves (56.3%) over fruits (43.8%). Nitrogen uptake and distribution closely followed the pattern of biomass. CONCLUSION The Scrf-Nopt fertilization strategy coordinated the important role that N plays in total accumulation and well proportion of biomass and N in bitter gourd developmental processes. © 2017 Society of Chemical Industry.
Clostridium difficile PCR Cycle Threshold Predicts Free Toxin

ABSTRACT There is no stand-alone Clostridium difficile diagnostic that can sensitively and rapidly detect fecal free toxins. We investigated the performance of the C. difficile PCR cycle threshold (CT) for predicting free toxin status. Consecutive stool samples (n = 312) positive for toxigenic C. difficile by the GeneXpert C. difficile/Epi tcdB PCR assay were tested with the rapid membrane C. Diff Quik Chek Complete immunoassay (RMEIA). RMEIA toxin-negative samples were tested with the cell cytotoxicity neutralization assay (CCNA) and tgcBIOMICS enzyme-linked immunosorbent assay (ELISA). Using RMEIA alone or in combination with CCNA and/or ELISA as the reference method, the accuracy of CT was measured at different CT cutoffs. Using RMEIA as the reference method, a CT cutoff of 26.35 detected toxin-positive samples with a sensitivity, specificity, positive predictive value, and negative predictive value of 96.0% (95% confidence interval [CI], 90.2% to 98.9%), 65.9% (95% CI, 59.0% to 72.2%), 57.4% (95% CI, 52.7% to 62%), and 97.1% (95% CI, 92.8% to 98.9), respectively. Inclusion of CCNA in the reference method improved CT specificity to 78.0% (95% CI, 70.7% to 84.2%). Intercartridge lot CT variability measured as the average coefficient of variation was 2.8% (95% CI, 1.2% to 3.2%). Standardizing the input stool volume did not improve CT toxin specificity. The median CT values were not significantly different between stool samples with Bristol scores of 5, 6, and 7, between pediatric and adult samples, or between presumptive 027 and non-027 strains. In addition to sensitively detecting toxigenic C. difficile in stool, on-demand PCR may also be used to accurately predict toxin-negative stool samples, thus providing additional results in PCR-positive stool samples to guide therapy.
Investigating Parent Needs, Participation, and Psychological Distress in the Children's Hospital.

BACKGROUND AND OBJECTIVES Greater parent participation in a child's hospital care is associated with better child outcomes in the hospital and after discharge. This study examined the relationships between perceived need fulfillment for parents, parent participation in hospital care, and parent psychological distress. We hypothesized that greater perceived need fulfillment would be associated with greater participation in hospital care and decreased psychological distress. METHODS In this prospective cohort study, 166 parents completed questionnaires on a pediatric (nonintensive care) floor. Eligible parents were fluent in English and had a child who was hospitalized ≥2 nights. Previously validated questionnaires were used to assess parent participation in hospital care and psychological distress (defined here as symptoms of anxiety/depression). A modified version of the Bereaved Parent Needs Assessment was used to assess perceived need fulfillment. The association between perceived need fulfillment and each outcome variable was examined using multiple linear regression analyses. RESULTS Of 186 eligible parents, 166 were enrolled (1 declined, 19 missed/not present). In multivariable analyses, greater perceived need fulfillment was associated with greater participation in hospital care and fewer symptoms of depression, even after controlling for relevant covariates. Exploratory analyses identified needs that were differentially important within groups of parents at risk for distress. CONCLUSIONS This study suggests that assessing and supporting parent needs during a child's hospitalization may improve parent and child outcomes by increasing parents' ability to participate in hospital care and decreasing psychological distress. Future research is needed to investigate the impact of interventions targeting specific parent needs.
Assessment of alternative emergency treatments for symptomatic irreversible pulpitis: a randomized clinical trial

AIM To evaluate three emergency procedures for their ability to alleviate clinical symptoms associated with symptomatic teeth having signs of (at least) partial irreversible pulpitis. METHODOLOGY Sixty-six maxillary and mandibular molars were randomly assigned to a total pulpectomy group (TP; n = 22), partial pulpectomy group (PP; n = 22) or pulpotomy group (P; n = 22). Procedure durations were recorded. Patients answered a questionnaire on daily analgesic requirements and about clinical symptoms (pain intensity, chewing sensitivity and thermal sensitivity) after the anaesthetic effect had disappeared (Day 0) and on Days 1, 3 and 7 post-treatment. RESULTS The total pulpectomy group was associated with the longest procedures (median, 24 min), followed by the partial pulpectomy and pulpotomy groups (P < 0.001 for all). In all three groups, pain intensity, thermal sensitivity and chewing sensitivity decreased significantly from the preoperative time-point to Day 7 (P < 0.001 for all). The total pulpectomy group reported greater reductions in pain intensity than the pulpotomy group between Days 0 and 7, Days 1 and 3, and Days 1 and 7 (P < 0.001 for all). No other intergroup differences were noted regarding reductions in pain intensity, and none were observed with respect to changes in prevalence of thermal sensitivity and chewing sensitivity. There were also no significant intergroup differences regarding the analgesic requirements throughout the 7 days. CONCLUSION As emergency treatments for teeth having signs of irreversible pulpitis, pulpotomy, partial pulpectomy and total pulpectomy were comparable with respect to relieving clinical symptoms. Pulpotomy may be preferred because it requires significantly less time and is a simple technique that relieves symptoms quickly and effectively.
Utilisation of Waste Heat Energy from an Internal Combustion Engine for Tri-generation

ii ACKNOWLEDGEMENT . iv LIST OF PUBLICATIONS . vi TABLE OF CONTENTS . vii LIST OF FIGURES . xii LIST OF TABLES . xvii NOMENCLATURE . xviii ATTESTATION OF AUTHORSHIP . xxii Chapter 1: Introduction . 1 1.1 Overview . 1 1.2 Waste heat . 3 1.3 Co-generation . 5 1.4 Tri-generation . 5 1.4. 1 Components of tri-generation systems . 6 1.4. 2 ICE based tri-generation system . 7 1.4. 3 Decentralised tri-generation system . 8 1.4. 4 Studies on decentralised tri-generation systems . 8 1.5 Research Question . 11 Chapter 2: Preliminary experimental investigation. 12
HpBase: A genome database of a sea urchin, Hemicentrotus pulcherrimus

To understand the mystery of life, it is important to accumulate genomic information for various organisms because the whole genome encodes the commands for all the genes. Since the genome of Strongylocentrotus purpratus was sequenced in 2006 as the first sequenced genome in echinoderms, the genomic resources of other North American sea urchins have gradually been accumulated, but no sea urchin genomes are available in other areas, where many scientists have used the local species and reported important results. In this manuscript, we report a draft genome of the sea urchin Hemincentrotus pulcherrimus because this species has a long history as the target of developmental and cell biology in East Asia. The genome of H. pulcherrimus was assembled into 16,251 scaffold sequences with an N50 length of 143 kbp, and approximately 25,000 genes were identified in the genome. The size of the genome and the sequencing coverage were estimated to be approximately 800 Mbp and 100×, respectively. To provide these data and information of annotation, we constructed a database, HpBase (http://cell-innovation.nig.ac.jp/Hpul/). In HpBase, gene searches, genome browsing, and blast searches are available. In addition, HpBase includes the “recipes” for experiments from each lab using H. pulcherrimus. These recipes will continue to be updated according to the circumstances of individual scientists and can be powerful tools for experimental biologists and for the community. HpBase is a suitable dataset for evolutionary, developmental, and cell biologists to compare H. pulcherrimus genomic information with that of other species and to isolate gene information.
Angle-of-Arrival Estimation Using Different Phase Shifts Across Subarrays in Localized Hybrid Arrays

Angle-of-arrival (AoA) estimation, even for a single arriving signal, in a localized hybrid array is challenging and time-consuming due to a phase ambiguity problem. Subarrays use the same phase shifting values conventionally to exploit cross correlation between them. This results in the requirement of scanning multiple angles over excessively long periods to resolve the phase ambiguity problem. In this letter, we propose an approach which allows subarrays to use different phase shifts per estimation and can resolve the ambiguity problem by directly estimating the desired AoA parameter. This can potentially speed up the estimation and improve the estimation performance significantly. Simulation results are provided to demonstrate the effectiveness of the proposed approach.
Extracellular histones disarrange vasoactive mediators release through a COX‐NOS interaction in human endothelial cells

Extracellular histones are mediators of inflammation, tissue injury and organ dysfunction. Interactions between circulating histones and vascular endothelial cells are key events in histone‐mediated pathologies. Our aim was to investigate the implication of extracellular histones in the production of the major vasoactive compounds released by human endothelial cells (HUVECs), prostanoids and nitric oxide (NO). HUVEC exposed to increasing concentrations of histones (0.001 to 100 μg/ml) for 4 hrs induced prostacyclin (PGI2) production in a dose‐dependent manner and decreased thromboxane A2 (TXA2) release at 100 μg/ml. Extracellular histones raised cyclooxygenase‐2 (COX‐2) and prostacyclin synthase (PGIS) mRNA and protein expression, decreased COX‐1 mRNA levels and did not change thromboxane A2 synthase (TXAS) expression. Moreover, extracellular histones decreased both, eNOS expression and NO production in HUVEC. The impaired NO production was related to COX‐2 activity and superoxide production since was reversed after celecoxib (10 μmol/l) and tempol (100 μmol/l) treatments, respectively. In conclusion, our findings suggest that extracellular histones stimulate the release of endothelial‐dependent mediators through an up‐regulation in COX‐2‐PGIS‐PGI2 pathway which involves a COX‐2‐dependent superoxide production that decreases the activity of eNOS and the NO production. These effects may contribute to the endothelial cell dysfunction observed in histone‐mediated pathologies.
Maternal epigenetics and fetal and neonatal growth

Purpose of review The article provides an update on new insights of factors altering inherited maternal epigenome that ultimately affect fetal and neonatal growth. Recent findings A number of new publications have identified mechanisms through which maternal nutrition, environmental exposures such as stress and toxic substances altering expression of imprinted genes during pregnancy can influence fetal and neonatal phenotype and susceptibility to disease development later in life. The possible causes of metabolic syndrome by in-utero epigenetic alterations of genes involved in energy metabolism (PPAR&ggr; and PPAR&agr;), microRNAs, arginine methyltransferases, lysine demethylases, and histone deacetylaces have been elucidated. Moreover associations between methylation of key genes (NRC31, HSD11&bgr;1/2, GFI1) involved in the hypothalamic-pituitary-adrenal axis have been identified. Alcohol exposure during pregnancy was found to alter methylation patterns of several imprinted genes (H19, SLC22A18, SLC6A3, DRD4). Finally alterations in vulnerable epigenetic marks of imprinted genes such as H19/IGF2, during early stages of embryonic development result in intrauterine growth restriction. Summary All these investigations continue to provide new insights for improved clinical management of in-utero development.
Airway inflammation in chronic obstructive pulmonary disease (COPD): a true paradox

ABSTRACT Introduction: Chronic obstructive pulmonary disease (COPD) is primarily an airway condition, which mainly affects cigarette smokers and presents with shortness of breath that is progressive and poorly reversible. In COPD research, there has been a long held belief that airway disease progression is due to inflammation. Although this may be true in the airway lumen with innate immunity activated by the effect of smoke or secondary to infection, the accurate picture of inflammatory cells in the airway wall, where the pathophysiological COPD remodeling occurs, is uncertain and debatable. Areas covered: The current review provides a comprehensive literature survey of the changes in the main inflammatory cells in human COPD patients and focuses on contrarian views that affect the prevailing dogma on inflammation. The review also delves into the role of oxidative stress and inflammasomes in modulating the immune response in COPD. Further, the effects of inflammation in affecting the epithelium, fibroblasts, and airway remodeling are discussed. Expert commentary: Inflammation as a driving force for airway wall damage and remodelling in early COPD is at the very least ‘oversimplified’ and is likely to be misleading. This has serious implications for rational thinking about the illness, including pathogenesis and designing therapy.
Frequency‐Selective Attention in Auditory Scenes Recruits Frequency Representations Throughout Human Superior Temporal Cortex

&NA; A sound of interest may be tracked amid other salient sounds by focusing attention on its characteristic features including its frequency. Functional magnetic resonance imaging findings have indicated that frequency representations in human primary auditory cortex (AC) contribute to this feat. However, attentional modulations were examined at relatively low spatial and spectral resolutions, and frequency‐selective contributions outside the primary AC could not be established. To address these issues, we compared blood oxygenation level‐dependent (BOLD) responses in the superior temporal cortex of human listeners while they identified single frequencies versus listened selectively for various frequencies within a multifrequency scene. Using best‐frequency mapping, we observed that the detailed spatial layout of attention‐induced BOLD response enhancements in primary AC follows the tonotopy of stimulus‐driven frequency representations—analogous to the “spotlight” of attention enhancing visuospatial representations in retinotopic visual cortex. Moreover, using an algorithm trained to discriminate stimulus‐driven frequency representations, we could successfully decode the focus of frequency‐selective attention from listeners’ BOLD response patterns in nonprimary AC. Our results indicate that the human brain facilitates selective listening to a frequency of interest in a scene by reinforcing the fine‐grained activity pattern throughout the entire superior temporal cortex that would be evoked if that frequency was present alone.
Asymmetric dimethylarginine levels are associated with augmentation index across naïve untreated patients with different hypertension phenotypes

Asymmetric dimethylarginine (ADMA) is a robust marker of endothelial dysfunction in patients with essential hypertension. We investigated ADMA levels and their association with vascular damage in untreated hypertension. We enrolled consecutive patients with untreated, recently diagnosed hypertension and age‐matched normotensive individuals. 24‐hour blood pressure, central hemodynamics, and arterial stiffness were recorded. A total of 311 individuals were studied: 165 with essential hypertension, 50 with masked hypertension, 25 with white‐coat hypertension, and 71 normotensive individuals. ADMA levels significantly correlated with aortic augmentation index (AIx75) (r = .156, P = .006), aortic pulse pressure (r = .153, P = .007) and marginally with carotid‐femoral pulse wave velocity (r = .110, P = .051), as well as with diastolic office BP. In the multivariate model, aortic AIx75 and age were the only statistically significant predictors of ADMA. This is the largest study to document an independent association between ADMA and aortic AIx75 but not with other indices of arterial stiffness.
Public perceptions of personalised nutrition through the lens of Social Cognitive Theory

Social Cognitive Theory has been used to explain findings derived from focus group discussions (N = 4) held in the United Kingdom with the aim of informing best practice in personalised nutrition. Positive expectancies included weight loss and negative expectancies surrounded on-line security. Monitoring and feedback were crucial to goal setting and progress. Coaching by the service provider, family and friends was deemed important for self-efficacy. Paying for personalised nutrition symbolised commitment to behaviour change. The social context of eating, however, was perceived a problem and should be considered when designing personalised diets. Social Cognitive Theory could provide an effective framework through which to deliver personalised nutrition.
Individual Differences in the Alignment of Structural and Functional Markers of the V5/MT Complex in Primates

Extrastriate visual area V5/MT in primates is defined both structurally by myeloarchitecture and functionally by distinct responses to visual motion. Myelination is directly identifiable from postmortem histology but also indirectly by image contrast with structural magnetic resonance imaging (sMRI). First, we compared the identification of V5/MT using both sMRI and histology in Rhesus macaques. A section-by-section comparison of histological slices with in vivo and postmortem sMRI for the same block of cortical tissue showed precise correspondence in localizing heavy myelination for V5/MT and neighboring MST. Thus, sMRI in macaques accurately locates histologically defined myelin within areas known to be motion selective. Second, we investigated the functionally homologous human motion complex (hMT+) using high-resolution in vivo imaging. Humans showed considerable intersubject variability in hMT+ location, when defined with myelin-weighted sMRI signals to reveal structure. When comparing sMRI markers to functional MRI in response to moving stimuli, a region of high myelin signal was generally located within the hMT+ complex. However, there were considerable differences in the alignment of structural and functional markers between individuals. Our results suggest that variation in area identification for hMT+ based on structural and functional markers reflects individual differences in human regional brain architecture.