Miracle-dz/UniFAR-FTUs huggingface dataset:
Aberrant expression of PAFAH1B3 associates with poor prognosis and affects proliferation and aggressiveness in hypopharyngeal squamous cell carcinoma

Background Hypopharyngeal squamous cell carcinoma (HSCC) is among the most lethal tumors encountered in the head and neck, and currently lacks satisfactory therapeutic targets. Platelet activating factor acetylhydrolase 1B3 (PAFAH1B3), a cancer-relevant metabolic driver, is reported to play a critical role in controlling tumorigenesis and aggressiveness in several types of cancers. However, the role of PAFAH1B3 in HSCC progression has not yet been identified. Methods The expression pattern of PAFAH1B3 was examined using immunohistochemistry in 83 HSCC tumor tissues and 44 paired adjacent non-tumor samples. Univariate and multivariate analyses were conducted to explore its association with prognosis of HSCC. In vitro loss-of-function assays were performed to explore the impact of PAFAH1B3 knockdown on the biological phenotype of the human HSCC cell line, ie, FaDu cells. Results PAFAH1B3 was overly expressed in the HSCC tumor tissues compared with the adjacent non-tumor samples. Moreover, high expression of PAFAH1B3 was positively correlated with cervical lymph node metastasis. PAFAH1B3 overexpression was associated with poor outcome in HSCC, but it was not an independent prognostic indicator. Furthermore, in vitro loss-of function experiments demonstrated that PAFAH1B3 knockdown suppressed cell proliferation by inducing apoptosis and disrupting cell cycle process, and the migratory and invasive capacities were also attenuated in the absence of PAFAH1B3. Conclusion This study for the first time demonstrated the clinical value and the role of PAFAH1B3 in the biological function of HSCC. This work suggested that PAFAH1B3 might serve as a potential therapeutic target for HSCC patients.
Fatal Gunshot Wounds Between 1995 and 2001 in a Highly Populated Region in Finland

Gunshot injuries are a major problem worldwide from the human, medical, and economic perspectives. The number and characteristics of gunshot fatalities have been observed to vary significantly between countries. This study analyzes fatal gunshot wounds in the region of Uusimaa, Southern Finland, between 1995 and 2001. Gunshot wounds were typically found in suicides committed by men aged between 20 and 60 years. In most cases, a handgun was used. Mental disorders were present in the history of almost one quarter of the victims. Alcohol was identified in postmortem toxicology in half of the cases, but drugs of abuse were relatively uncommon. The autopsy rate in Finland is among the highest of the European Union countries, and a medicolegal investigation is performed in virtually all fatal gunshot incidents. This study is therefore representative of forensic investigations of gunshot fatalities in Finland overall.
A study on the influence of parameter 6 on performance of RBF neural networks trained with the dynamic decay adjustment algorithm

The dynamic decay adjustment (DDA) algorithm is a fast constructive algorithm for training RBF and PNN neural networks. The algorithm has two parameters, namely, /spl theta//sup +/ and /spl theta//sup -/. The papers which introduced DDA argued that those parameters would not heavily influence classification performance and therefore they recommended using always the default values of these parameters. In contrast, this paper shows that smaller values of parameter /spl theta/ can, for a considerable number of datasets, result in remarkable improvement in generalization performance.
Shared Syntax in Language Production and Language Comprehension—An fMRI Study

During speaking and listening syntactic processing is a crucial step. It involves specifying syntactic relations between words in a sentence. If the production and comprehension modality share the neuronal substrate for syntactic processing then processing syntax in one modality should lead to adaptation effects in the other modality. In the present functional magnetic resonance imaging experiment, participants either overtly produced or heard descriptions of pictures. We looked for brain regions showing adaptation effects to the repetition of syntactic structures. In order to ensure that not just the same brain regions but also the same neuronal populations within these regions are involved in syntactic processing in speaking and listening, we compared syntactic adaptation effects within processing modalities (syntactic production-to-production and comprehension-to-comprehension priming) with syntactic adaptation effects between processing modalities (syntactic comprehension-to-production and production-to-comprehension priming). We found syntactic adaptation effects in left inferior frontal gyrus (Brodmann's area [BA] 45), left middle temporal gyrus (BA 21), and bilateral supplementary motor area (BA 6) which were equally strong within and between processing modalities. Thus, syntactic repetition facilitates syntactic processing in the brain within and across processing modalities to the same extent. We conclude that that the same neurobiological system seems to subserve syntactic processing in speaking and listening.
Multihop Connectivity of Ad Hoc Networks With Randomly Oriented Directional Antennas

Directional antennas and beamforming can significantly improve point-to-point wireless links when perfectly aligned. In this letter we investigate the extreme opposite where antenna orientations and positions are chosen at random in the presence of Rayleigh fading. We show that while the 1-hop network connectivity is deteriorated, the multihop routes improve, especially in the dense regime. We derive closed form expressions for the expectation of the 1-hop and 2-hop degree, which are verified through computer simulations. We conclude that node density does not greatly affect the number of hops required between stations while simple random beamforming schemes do, thus returning substantial network performance benefits due to the existence of shorter multi-hop paths.
Maternal Diet and Infant Leukemia: The DNA Topoisomerase II Inhibitor Hypothesis: A Report from the Children's Oncology Group

Background: The MLL 11q23 translocation arises in utero and is present in 75% of infant leukemias. That MLL+ acute myeloid leukemia (AML) can arise following chemotherapy with DNA topoisomerase II (DNAt2) inhibitors suggests that these substances, which also occur naturally in foods, may contribute toward infant leukemia. We hypothesized that maternal consumption of dietary DNAt2 inhibitors during pregnancy would increase the risk of infant leukemia, particularly AML(MLL+). Methods: This Children's Oncology Group case-control study consisted of 240 incident cases of infant acute leukemia [AML and acute lymphoblastic leukemia (ALL)] diagnosed during 1996 to 2002 and 255 random digit dialed controls. Maternal diet during pregnancy was determined through a food frequency questionnaire. An index of specific foods identified a priori to contain DNAt2 inhibitors as well as vegetables and fruits were created and analyzed using unconditional logistic regression. Results: There was little evidence of an association between the specific DNAt2 index and leukemia overall and by subtype. An exception was AML(MLL+); odds ratios (95% confidence intervals) comparing the second to fourth quartiles to the first were 1.9 (0.5-7.0), 2.1 (0.6-7.7), and 3.2 (0.9-11.9), respectively (P for trend = 0.10). For the vegetable and fruit index, there were significant or near-significant inverse linear trends for all leukemias combined, ALL(MLL+), and AML(MLL−). Conclusion: Overall, maternal consumption of fresh vegetables and fruits during pregnancy was associated with a decreased risk of infant leukemia, particularly MLL+. However, for AML(MLL+) cases, maternal consumption of specific DNAt2 inhibitors seemed to increase risk. Although based on small numbers, these data provide some support for distinct etiologic pathways in infant leukemia.
RELATIONSHIP AMONG EMOTIONAL INTELLIGENCE, DEVIANT WORKPLACE BEHAVIOR AND JOB PERFORMANCE: AN EMPIRICAL STUDY

The purpose of the study is to examine the relationships among emotional intelligence, deviant work-place behavior, and job performance. Emotional intelligence and deviant workplace behavior was measured by the Emotional Quotient Index and Multidimensional Scale respectively while job performance was assessed by Tsui et al.,’s Job Performance Scale. Data for this study were collected from 201 employed MBA students studying at four private universities in Chittagong, a port city of Bangladesh. They were asked to rate their supervisors’ emotional intelligence, deviant workplace behavior, and job performance with the help of self-administered questionnaires. In data collection, this study used convenience sampling. Data collected were analyzed using descriptive statistics, bivariate correlation, and regression analysis. Results indicated a negative correlation between emotional intelligence and deviant workplace behavior (r = -.52**), and deviant workplace behavior and job performance (r = -.45**) while emotional intelligence was found to correlate positively with job performance (r = .58**). The main implication of the study is that emotionally intelligent employees exhibit higher job performance and a lesser tendency to take part in deviant workplace behavior. The other implication is that the presence of deviant workplace behavior was a prior indication of poor job performance; hence supervisors should use their emotional intelligence competencies to improve their own and others’ job performance. The most important limitation of the study was that it used convenience samples, which might limit the generalizability of the results. Future research directions are also discussed. Classification- JEL:
Acute worsening of chronic depression during a double-blind, randomized clinical trial of antidepressant efficacy: differences by sex and menopausal status.

OBJECTIVE Acute worsening of depression can negatively impact the outcomes of clinical trials of antidepressants and patient compliance to treatment. We hypothesized that acute worsenings would be more frequent in premenopausal women, relative to men or postmenopausal women, and in women who had demonstrated premenstrual symptom exacerbations (PMEs) prior to treatment, relative to those who had demonstrated no PMEs. METHOD Subjects diagnosed with DSM-III-R chronic major depressive disorder or double depression (dysthymia with concurrent major depressive episode) were randomly assigned between February 1993 and December 1994 to 12 weeks of double-blind treatment with flexibly-dosed sertraline or imipramine, with crossover to the alternate drug in the absence of response. A 6-point or more increase in the 17-item Hamilton Rating Scale for Depression relative to the (7-14 day) previous visit defined worsening. PME was assessed through daily diaries prior to treatment. RESULTS There were 3582 evaluable visits attended by 554 subjects. Premenopausal women had a deteriorating depressive presentation at a greater proportion of their visits (8.6%) than did postmenopausal women (4.5%, p < .01) or men (5.9%, p < .01). The presence of PME at baseline was associated with more worsenings than the absence of PME (12.0% vs. 7.3%, p < .05). Results were similar whether the subject was treated with sertraline or imipramine. Nonresponse at treatment completion was more likely among subjects with worsening (p < .01). Dropouts were more likely than completers to have had an exacerbation at their terminal visit (p < .05). CONCLUSION Acute worsening of depression was associated with reproductive variables and negatively affected clinical trial outcomes including early treatment discontinuation and nonresponse.
Biometric animal databases from field photographs: identification of individual zebra in the wild

We describe an algorithmic and experimental approach to a fundamental problem in field ecology: computer-assisted individual animal identification. We use a database of noisy photographs taken in the wild to build a biometric database of individual animals differentiated by their coat markings. A new image of an unknown animal can then be queried by its coat markings against the database to determine if the animal has been observed and identified before. Our algorithm, called StripeCodes, efficiently extracts simple image features and uses a dynamic programming algorithm to compare images. We test its accuracy against two different classes of methods: Eigenface, which is based on algebraic techniques, and matching multi-scale histograms of differential image features, an approach from signal processing. StripeCodes performs better than all competing methods for our dataset, and scales well with database size.
Human Rhinovirus Infections in Rural Thailand: Epidemiological Evidence for Rhinovirus as Both Pathogen and Bystander

Background We describe human rhinovirus (HRV) detections in SaKaeo province, Thailand. Methods From September 1, 2003–August 31, 2005, we tested hospitalized patients with acute lower respiratory illness and outpatient controls without fever or respiratory symptoms for HRVs with polymerase chain reaction and molecularly-typed select HRVs. We compared HRV detection among hospitalized patients and controls and estimated enrollment adjusted incidence. Results HRVs were detected in 315 (16%) of 1919 hospitalized patients and 27 (9.6%) of 280 controls. Children had the highest frequency of HRV detections (hospitalized: <1 year: 29%, 1–4 year: 29%, ≥65 years: 9%; controls: <1 year: 24%, 1–4 year: 14%, ≥65 years: 2.8%). Enrollment adjusted hospitalized HRV detection rates were highest among persons aged <1 year (1038/100,000 persons/year), 1–4 years (457), and ≥65 years (71). All three HRV species were identified, HRV-A was the most common species in most age groups including children aged <1 year (61%) and all adult age groups. HRV-C was the most common species in the 1–4 year (51%) and 5–19 year age groups (54%). Compared to controls, hospitalized adults (≥19 years) and children were more likely to have HRV detections (odds ratio [OR]: 4.8, 95% confidence interval [CI]: 1.5, 15.8; OR: 2.0, CI: 1.2, 3.3, respectively) and hospitalized children were more likely to have HRV-A (OR 1.7, CI: 0.8, 3.5) or HVR-C (OR 2.7, CI: 1.2, 5.9) detection. Conclusions HRV rates were high among hospitalized children and the elderly but asymptomatic children also had substantial HRV detection. HRV (all species), and HRV-A and HRV-C detections were epidemiologically-associated with hospitalized illness. Treatment or prevention modalities effective against HRV could reduce hospitalizations due to HRV in Thailand.
Distributed MAC protocol for networks with multipacket reception capability and spatially distributed nodes

The physical layer of future wireless networks will be based on novel radio technologies such as Ultra-Wideband (UWB) and Multiple-Input Multiple-Output (MIMO). One of the important capabilities of such technologies is the ability to capture a few packets simultaneously. This capability has the potential to improve the performance of the MAC layer. However, we show that in networks with spatially distributed nodes, reusing MAC protocols originally designed for narrow-band systems (e.g., CSMA/CA) is inefficient. It is well known that when networks with spatially distributed nodes operate with such MAC protocols, the channel may be captured by nodes that are near the destination. We show that when the physical layer enables multi-packet reception, the negative implications of reusing the legacy protocols include not only such unfairness but also a significant throughput reduction. We present a number of simple alternative backoff mechanisms that attempt to overcome the throughput reduction phenomenon. We evaluate the performance of these mechanisms via exact analysis, approximations, and simulation, thereby demonstrating that they usually outperform the legacy backoff mechanisms. We then discuss the implications of the results on developing realistic MAC protocols for networks with a multi-packet reception capability and in particular for UWB networks. Thesis Supervisor: Eytan Modiano Title: Associate Professor Acknowledgments I am profoundly thankful to my advisor, Prof. Eytan Modiano, and Post Doc. Assoc. Gil Zussman for their support in this work, for their guidance that helped me continue my research in the right direction and for their friendly mood that makes it enjoyable to work with them. I also would like to thank my family for their endless moral support throughout my career. Finally, this work was supported in part by ONR under grant N000140610064, and by a grant from Draper Laboratory.
Genome-Wide Association Studies of Endometrial Cancer: Latest Developments and Future Directions

Endometrial cancer, the most commonly diagnosed cancer of the female reproductive tract in developed countries, has a heritable component. To date, 16 genetic risk regions have been robustly discovered by genome-wide association studies (GWAS) of endometrial cancer. Post-GWAS analyses including expression quantitative trait loci analysis and laboratory-based functional studies have been successful in identifying genes and pathways involved in endometrial carcinogenesis. Mendelian randomization analysis studies have confirmed factors causal for endometrial cancer risk, including increased body mass index and early onset of menarche. In this review, we summarize findings from GWAS and post-GWAS analyses of endometrial cancer. We discuss clinical implications of these findings, current knowledge gaps, and future directions for the study of endometrial cancer genetics.
Prevalence of CADASIL and Fabry Disease in a Cohort of MRI Defined Younger Onset Lacunar Stroke

Background and Purpose Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), caused by mutations in the NOTCH3 gene, is the most common monogenic disorder causing lacunar stroke and cerebral small vessel disease (SVD). Fabry disease (FD) due to mutations in the GLA gene has been suggested as an underdiagnosed cause of stroke, and one feature is SVD. Previous studies reported varying prevalence of CADASIL and FD in stroke, likely due to varying subtypes studied; no studies have looked at a large cohort of younger onset SVD. We determined the prevalence in a well-defined, MRI-verified cohort of apparently sporadic patients with lacunar infarct. Methods Caucasian patients with lacunar infarction, aged ≤70 years (mean age 56.7 (SD8.6)), were recruited from 72 specialist stroke centres throughout the UK as part of the Young Lacunar Stroke DNA Resource. Patients with a previously confirmed monogenic cause of stroke were excluded. All MRI’s and clinical histories were reviewed centrally. Screening was performed for NOTCH3 and GLA mutations. Results Of 994 subjects five had pathogenic NOTCH3 mutations (R169C, R207C, R587C, C1222G and C323S) all resulting in loss or gain of a cysteine in the NOTCH3 protein. All five patients had confluent leukoaraiosis (Fazekas grade ≥2). CADASIL prevalence overall was 0.5% (95% CI 0.2%-1.1%) and among cases with confluent leukoaraiosis 1.5% (95% CI 0.6%-3.3%). No classic pathogenic FD mutations were found; one patient had a missense mutation (R118C), associated with late-onset FD. Conclusion CADASIL cases are rare and only detected in SVD patients with confluent leukoaraiosis. No definite FD cases were detected.
Neural mechanisms for reducing uncertainty in 3D depth perception

In order to navigate and interact within their environment, animals must process and interpret sensory information to generate a representation or ‘percept’ of that environment. However, sensory information is invariably noisy, ambiguous, or incomplete due to the constraints of sensory apparatus, and this leads to uncertainty in perceptual interpretation. To overcome these problems, sensory systems have evolved multiple strategies for reducing perceptual uncertainty in the face of uncertain visual input, thus optimizing goal-oriented behaviours. Two available strategies have been observed even in the simplest of neural systems, and are represented in Bayesian formulations of perceptual inference: sensory integration and prior experience. In this thesis, I present a series of studies that examine these processes and the neural mechanisms underlying them in the primate visual system, by studying depth perception in human observers. Chapters 2 & 3 used functional brain imaging to localize cortical areas involved in integrating multiple visual depth cues, which enhance observers’ ability to judge depth. Specifically, we tested which of two possible computational methods the brain uses to combine depth cues. Based on the results we applied disruption techniques to examine whether these select brain regions are critical for depth cue integration. Chapters 4 & 5 addressed the question of how memory systems operating over different time scales interact to resolve perceptual ambiguity when the retinal signal is compatible with more than one 3D interpretation of the world. Finally, we examined the role of higher cortical regions (parietal cortex) in depth perception and the resolution of ambiguous visual input by testing patients with brain lesions.
Histocompatibility antigen expression in pulmonary carcinomas as indication of differentiation and of special subtypes

In 70 human carcinomas of the lung the expression of histocompatibility antigens (HLA) was investigated by using monoclonal antibodies in frozen sections. The immunoreactive tumor volume was determined morphometrically. The tumor types showed a different pattern of HLA expression. In squamous cell carcinomas (SQC) and small cell carcinomas (SCC) the HLA‐A,B,C expression varied in a great range from 0% to 100% of positive tumor volume. For the most part, HLA‐DR was not demonstrable. In adenocarcinomas (AC) and large cell carcinomas two different populations were observed. One showed a pattern of HLA expression as seen in SQC. Electron microscopically these AC (type I) (AC/I) were characterized by intracytoplasmic mucin granules indicating a phenotypical relationship to goblet cells. The other–nearly 50% of adenocarcinomas and one third of large cell carcinomas–expressed both HLA antigens homogeneously in the total tumor volume. Electron microscopically the characteristics of type II pneumocytes and Clara cells were seen in tumor cells of these AC (type II) (AC/II), consisting in lamellar bodies and apically located electron‐dense granules. In SQC and AC/I a significant correlation was found between grades of differentiation and mitotic activity on the one side, and expression of HLA‐A,B,C on the other. The loss of HLA‐A,B,C expression seemed to be an indication of a lower grade of differentiation: the smallest expression of HLA‐A,B,C occurred in SCC.
Mapping and localization with RFID technology

We analyze whether radio frequency identification (RFID) technology can be used to improve the localization of mobile robots and persons in their environment. In particular we study the problem of localizing RFID tags with a mobile platform that is equipped with a pair of RFID antennas. We present a probabilistic measurement model for RFID readers that allow us to accurately localize RFID tags in the environment. We also demonstrate how such maps can be used to localize a robot and persons in their environment. Finally, we present experiments illustrating that the computational requirements for global robot localization can be reduced strongly by fusing RFID information with laser data.