Miracle-dz/UniFAR-FTUs huggingface dataset:
Accessing and Processing Sensing Data

Scientific models are increasingly dependent on processing large volumes of streamed sensing data from a wide range of sensors, from ground based to satellite embarked infrareds. The proliferation, variety and ubiquity of those devices have added new dimensions to the problem of data handling in computational models. This raises several issues, one of which - providing means to access and process these data - is tackled by this paper. Our solution involves the design and implementation of a framework for sensor data management, which relies on a specific component technology - digital content component (DCC). DCCs homogeneously encapsulate individual sensors, sensor networks and sensor data archival files. They also implement facilities for controlling data production, integration and publication. As a result, developers need not concern themselves with sensor particularities, dealing instead with uniform interfaces to access data, regardless of the nature of the data providers.
Universal screening for methicillin-resistant Staphylococcus aureus at hospital admission and nosocomial infection in surgical patients.

CONTEXT Experts and policy makers have repeatedly called for universal screening at hospital admission to reduce nosocomial methicillin-resistant Staphylococcus aureus (MRSA) infection. OBJECTIVE To determine the effect of an early MRSA detection strategy on nosocomial MRSA infection rates in surgical patients. DESIGN, SETTING, AND PATIENTS Prospective, interventional cohort study conducted between July 2004 and May 2006 among 21 754 surgical patients at a Swiss teaching hospital using a crossover design to compare 2 MRSA control strategies (rapid screening on admission plus standard infection control measures vs standard infection control alone). Twelve surgical wards including different surgical specialties were enrolled according to a prespecified agenda, assigned to either the control or intervention group for a 9-month period, then switched over to the other group for a further 9 months. INTERVENTIONS During the rapid screening intervention periods, patients admitted to the intervention wards for more than 24 hours were screened before or on admission by rapid, multiplex polymerase chain reaction. For both intervention (n=10 844) and control (n=10 910) periods, standard infection control measures were used for patients with MRSA in all wards and consisted of contact isolation of MRSA carriers, use of dedicated material (eg, gown, gloves, mask if indicated), adjustment of perioperative antibiotic prophylaxis of MRSA carriers, computerized MRSA alert system, and topical decolonization (nasal mupirocin ointment and chlorhexidine body washing) for 5 days. MAIN OUTCOME MEASURES Incidence of nosocomial MRSA infection, MRSA surgical site infection, and rates of nosocomial acquisition of MRSA. RESULTS Overall, 10 193 of 10 844 patients (94%) were screened during the intervention periods. Screening identified 515 MRSA-positive patients (5.1%), including 337 previously unknown MRSA carriers. Median time from screening to notification of test results was 22.5 hours (interquartile range, 12.2-28.2 hours). In the intervention periods, 93 patients (1.11 per 1000 patient-days) developed nosocomial MRSA infection compared with 76 in the control periods (0.91 per 1000 patient-days; adjusted incidence rate ratio, 1.20; 95% confidence interval, 0.85-1.69; P = .29). The rate of MRSA surgical site infection and nosocomial MRSA acquisition did not change significantly. Fifty-three of 93 infected patients (57%) in the intervention wards were MRSA-free on admission and developed MRSA infection during hospitalization. CONCLUSION A universal, rapid MRSA admission screening strategy did not reduce nosocomial MRSA infection in a surgical department with endemic MRSA prevalence but relatively low rates of MRSA infection. TRIAL REGISTRATION isrctn.org Identifier: ISRCTN06603006.
depression . exercise-induced ST segment pectoris . Reduction of Antilipolytic therapy in angina

A double-blind cross-over study was performed on 12 men with stable angina pectoris in order to determine the effect of antilipolytic treatment on exercise tolerance and exercise-induced electrocardiographic changes. The men were exercised to the onset of anginal pain using a reproducible and standardized ergometric load. A nicotinic acid analogue was used to reduce plasma free fatty acids andfree glycerol before and during exercise testing and to eliminate their post-exercise rise. This was associated with significant reduction of exercise-induced ST segment depression (P<0005), though there was no significant difference in the duration of exercise before the onset of pain. A change in the proportions of lipid and carbohydrate for oxidation by the ischaemic myocardium, making relatively more glucose available, is a likely explanation.
Changes in the Expression Patterns of the Genes Involved in the Segregation and Function of Inner Cell Mass and Trophectoderm Lineages During Porcine Preimplantation Development

Abstract In mouse embryos, segregation of the inner cell mass (ICM) and trophectoderm (TE) lineages is regulated by genes, such as OCT-4, CDX2 and TEAD4. However, the molecular mechanisms that regulate the segregation of the ICM and TE lineages in porcine embryos remain unknown. To obtain insights regarding the segregation of the ICM and TE lineages in porcine embryos, we examined the mRNA expression patterns of candidate genes, OCT-4, CDX2, TEAD4, GATA3, NANOG, FGF4, FGFR1-IIIc and FGFR2-IIIc, in blastocyst and elongated stage embryos. In blastocyst embryos, the expression levels of OCT-4, FGF4 and FGFR1-IIIc were significantly higher in the ICM than in the TE, while the CDX2, TEAD4 and GATA3 levels did not differ between the ICM and TE. The expression ratio of CDX2 to OCT-4 (CDX2/OCT-4) also did not differ between the ICM and TE at the blastocyst stage. In elongated embryos, OCT-4, NANOG, FGF4 and FGFR1-IIIc were abundantly expressed in the embryo disc (ED; ICM lineage), but their expression levels were very low in the TE. In contrast, the CDX2, TEAD4 and GATA3 levels were significantly higher in the TE than in the ED. In addition, the CDX2/OCT-4 ratio was markedly higher in the TE than in the ED. We demonstrated that differences in the expression levels of OCT-4, CDX2, TEAD4, GATA3, NANOG, FGF4, FGFR1-IIIc and FGFR2-IIIc genes between ICM and TE lineages cells become more clear during development from porcine blastocyst to elongated embryos, which indicates the possibility that in porcine embryos, functions of ICM and TE lineage cells depend on these gene expressions proceed as transition from blastocyst to elongated stage.
UniNE at CLEF 2012

As participants in this CLEF evaluation campaign, our first objective is to propose and evaluate various indexing and search strategies for the CHiC corpus, in order to compare the retrieval effectiveness across different IR mod- els. Our second objective is to measure the relative merit of various stemming strategies when used for the French and English monolingual task in the CH context. Our third objective is to assess the effectiveness of query translation methods in a bilingual retrieval. To do so we evaluated the CHiC test- collections using Okapi, various IR models derived from the Divergence from Randomness (DFR) paradigm together with the dtu-dtn vector-space model. We also evaluated different pseudo-relevance feedback approaches. In the bi- lingual task, we conducted our search on the English corpus using the French and German topics with two different translations for each of them. For both English and French languages, we find that word-based indexing with our light stemming procedure results in better retrieval effectiveness than with other strategies. When ignoring stemming, the performance variations were relative- ly small yet for the French corpus better than applying a light stemmer. In bilin- gual level results show that using a combination of translation resources gives better results than a single source.
The spatial distribution of elemental abundances in the intracluster medium as observed with XMM-Newton

XMM-Newton observations of 19 galaxy clusters are used to measure the elemental abundances and their spatial distributions in the intracluster medium. The sample mainly consists of X-ray bright and relaxed clusters with a cD galaxy. Along with detailed Si, S and Fe radial abundance distributions within 300-700 kpc in radius, the O abundances are accurately derived in the central region of the clusters. The Fe abundance maxima towards the cluster center, possibly due to the metals from the cD galaxy, are spatially resolved. The Si and S abundances also exhibit central increases in general, resulting in uniform Fe-Si-S ratios within the cluster. In contrast, the O abundances are in general uniform over the cluster. The mean O to Fe ratio within the cluster core is sub-solar, while that of the cluster scale is larger than the solar ratio. These measurements indicate that most of the Fe-Si-S and O in the intracluster medium have different origins, presumably in supernovae Ia and II, respectively. The obtained Fe and O mass are also used to discuss the past star formation history in clusters.
A novel approach to structure generation for texture improvement in a soymilk-dairy gel

Alexandra Grygorczyk University of Guelph, 2012 Advisor: Milena Corredig Co-advisor: Lisa Duizer The current study attempts to improve the texture properties of a fermented product containing soymilk and milk. Preferred Attribute Elicitation (PAE) was examined as a novel sensory methodology for extracting important attributes influencing consumer liking. This method was applied on commercial yogurt products, and it was determined that texture was important to consumer acceptance, and that texture attributes such as graininess and runny texture were detrimental to consumer liking. Outcomes of the PAE method were compared to those obtained from a conventional trained panel method. It was determined that the PAE method was able to characterize the product textures in a meaningful way, resulting in a product map that closely resembled that obtained by the trained panel method. A mixed protein network was then generated, and simultaneous gelation of both soy and dairy proteins lead to an improved gel structure as compared to gelation of either soy or dairy proteins alone in the mixed system. In addition, it was determined that the presence of homogenized fat globules in the network resulted in fermented products with increased mouthcoating and thickness, particularly when cream was homogenized with dairy milk, with or without soymilk in the mix. It was noted that the order of homogenization (cream with either soymilk, milk alone or with the mix) affected the size and number of aggregates as well as number of interconnecting strands. Additionally, aggregation of milk proteins before soy proteins generated gels with higher slipperiness and fattiness perceptions than gels made from simultaneous milk and soy protein aggregation. This study suggested that it is possible to generate desirable texture properties from a mixture of soy protein and milk proteins, and that it is of fundamental importance to fine tune the structure within the matrix to obtain optimal texture perception.
A Study on Information Security Management with Personal Data Protection

In the process of standardization, whether the announcement of a standard represents a cause or an outcome, it is opportunity of the trend of standardization or achievement. The process of standardization is to understand "why" and "how" to explore the detailed outline of a time flow. From a long-term perspective, a standard is the milestone of the standardization process. On May 26th 2010, with the announcement of the Personal Data Protection Act in Taiwan, information security management (ISM) of the Personal Data Protection Act has received much attention from the public. This study is centered on the working items of standards announced by the International Organization for Standardization (ISO) and the ongoing information security management system (ISMS) standards and standardization in order to propose standards which comply with the ISMS of the Personal Data Protection Act and methods which increase implementation control measures.
Endogenous patterns of BMP signaling during early chick development.

Bone morphogenetic proteins (BMPs) are members of the transforming growth factor beta superfamily signaling molecules that play important roles in a wide variety of developmental processes. In this study, we have used an antibody specific for the phosphorylated and activated form of Smad1 to examine endogenous patterns of BMP signaling in chick embryos during early development. We find complex spatial and temporal distributions of BMP signaling that elucidate how BMPs may function in multiple patterning events in the early chick embryo. In the pregastrula embryo, we find that BMP signaling is initially ubiquitous and is extinguished in the epiblast at the onset of primitive streak formation. At the head process stage, BMP signaling is inactivated in prospective neural plate, while it is strongly activated at the neural plate border, a region which is populated by cells that will give rise to neural crest. During later development, we find a dynamic spatiotemporal activation of BMP signaling along the rostrocaudal axis, in the dorsal neural tube, in the notochord, and in the somites during their maturation process. We discuss the implication of our results for endogenous functions of BMP signaling during chick development.
Association between oxidative DNA damage and the expression of 8-oxoguanine DNA glycosylase 1 in lung epithelial cells of neonatal rats exposed to hyperoxia

Previous studies have demonstrated that oxidative stress-induced lung injury is involved in the occurrence and developmental process of bronchopulmonary dysplasia (BPD). The present study assessed whether oxidative DNA damage occurs in the early stages of hyperoxia-induced BPD in neonatal rats and evaluated the expression and localization of the DNA repair gene, 8-oxoguanine DNA glycosylase 1 (OGG1), upon exposure to hyperoxia. Neonatal rats and primary cultured neonatal rat alveolar epithelial type II (AECII) cells were exposed to hyperoxia (90% O2) or normoxia (21% O2) and the expression levels of 8-hydroxy-2′-deoxyguanosine (8-OHdG) in the lung tissues and AECII cells were determined using a competitive enzyme-linked immunosorbent assay. DNA strand breaks in the AECII cells were detected using a comet assay. The expression and localization of the OGG1 protein in the lung tissues and AECII cells were determined by immunofluorescence confocal microscopy and western blotting. The mRNA expression levels of OGG1 in the lung tissues and AECII cells were determined by reverse transcription polymerase chain reaction. The expression of 8-OHdG was elevated in the hyperoxia-exposed neonatal rat lung tissue and the AECII cells compared with the normoxic controls. The occurrence of DNA strand breaks in the AECII cells increased with increasing duration of hyperoxia exposure. The protein expression of OGG1 was significantly increased in the hyperoxia-exposed lung tissues and AECII cells, with OGG1 preferentially localized to the cytoplasm. No concomitant increase in the mRNA expression of OGG1 was detected. These results revealed that oxidative DNA damage occurred in lung epithelial cells during early-stage BPD, as confirmed by in vitro and in vivo hyperoxia exposure experiments, and the increased expression of OGG1 was associated with this process.
Synthetic circuit generation using clustering and iteration

The development of next-generation computer-aided design tools and field programmable gate array architectures require benchmark circuits to experiment with new algorithms and architectures. There has always been a shortage of good public benchmarks for these purposes, and even companies that have access to proprietary customer designs could benefit from designs that meet size and other particular specifications. In this paper, we present a new method of generating realistic synthetic benchmark circuits to help alleviate this shortage. The method significantly improves the quality of previous work by imposing a hierarchy of circuits through clustering and by using a simpler method of characterizing the nature of sequential circuits. Also, in contrast to current constructive generation methods (Hutton et al., 1998), (Hutton et al., 2002), (Darnauer and Dai, 1996), (Iwama and Hino, 1994), (Iwama et al., 1997), (Harlow and Brglez, 1997), (Ghosh et al., 1998), (http://www.cbl.ncsu.edu//spl bsol/-publications //spl bsol/-/spl bsol/#2000-TR@CBL-01-Ghosh), (Pistorius et al., 2000), (Stroobandt et al., 2000), (Verplaetse et al., 2002), we employ new iterative techniques in the generation that provide better control over the generated circuit's characteristics. As in previous work, we assess the realism of the generated circuits by comparing properties of real circuits and generated "clones" of the real circuit after placement and routing. On average, the real and clone circuits' total detailed wirelength differ by only 14%, a major improvement over previous results. In addition, the minimum track count is within 14% and the critical-path delay is within 10%.
Silencing of DLC1 Upregulates PAI-1 Expression and Reduces Migration in Normal Prostate Cells

Deleted in liver cancer 1 (DLC1) is a GTPase-activating protein (GAP) domain containing tumor suppressor that localizes to focal adhesions. In cancer cells, loss of DLC1 is known to enhance cancer cell migration. However, the role of DLC1 in normal cell migration has not been well studied. Here, we show that silencing of DLC1 (shDLC1) in normal prostate epithelial cells reduces cell migration in both Transwell and wound-healing assays. This migration defect is mainly due to upregulation of plasminogen activator inhibitor 1 (PAI-1). Silencing of PAI-1 rescues the shDLC1-reduced migration phenotype. Reexpression of DLC1 suppresses PAI-1 and restores the migration defect as well. In contrast, DLC1-K714E (GAP inactive) mutant neither decreases the PAI-1 level nor rescues the shDLC1 migration defect. Interestingly, DLC1-Y442F (tensin-binding and focal adhesion–localizing defective) mutant is able to suppress PAI-1 expression but does not restore the migration defect. Furthermore, PAI-1 upregulation in shDLC1 cells is EGFR-MEK pathway dependent and is able to promote in vitro angiogenesis. Together, our results show that at least the following two new mechanisms are involved in DLC1-mediated normal cell migration: (i) DLC1 modulates the expression of PAI-1, which is a negative regulator for cell migration, in a GAP domain and EGFR-MEK–dependent manner and (ii) Independent of PAI-1, the interaction of DLC1 with tensin members positively regulates cell migration. Mol Cancer Res; 10(1); 34–9. ©2011 AACR.
Monlingual document retrieval: English versus other European languages

The vast majority of research in information retrieval is done using English collections and topics. This raises questions about the effectiveness of retrieval strategies for other languages. To examine this issue, we focus on document retrieval in nine European languages. In particular, we investigate the effectiveness of language-dependent approaches to document retrieval, such as stemming and decompounding of language-independent approaches, such as character n-gramming; and of the combination of the two types ofapproaches. The experimental evidence is obtained using the 2003 test-suite of the cross-language evaluation forum (CLEF).
Cizolirtine Citrate (E-4018) in the Treatment of Chronic Neuropathic Pain

Summary This study was performed to determine the efficacy and safety of oral cizolirtine citrate, a novel agent, in the treatment of chronic neuropathic pain. Cizolirtine was tested in a double-blind, placebo-controlled, two-way crossover study, having previously been shown to have significant analgesic and anti-hyperalgesic action in neuropathic pain models and preliminary human studies. Twenty-five patients with neuropathic pain, which was persistent for at least three months, and scored >30 mm on a 100 mm visual analogue scale (VAS), were included. A subgroup of five patients had primary skin allodynia, i.e. pain evoked by non-noxious stimuli in the territory of the injured nerve. Cizolirtine 200 mg or placebo was administered twice daily for a treatment period of 21 days, each separated by a washout interval of 7 days. Assessments of skin allodynia were performed using the graded monofilaments (von Frey hairs) on days 1 (predose), 14 and 21 (90 min postdose). All patients were instructed to maintain a daily pain diary throughout the study. Results showed that the differences in VAS and allodynia scores between cizolirtine and placebo treatments were not significant in the overall analysis (p > 0.05); cizolirtine was well tolerated. In a subgroup of five patients with primary allodynia, a 53% reduction in VAS score from baseline at rest (p = 0.007) and 55% on movement (p = 0.0002) at day 21 was observed with cizolirtine, as compared to 8% at rest (p = 0.5215) and 13% on movement (p = 0.4187) with placebo. Similarly, allodynia improved with cizolirtine (p = 0.03) but not with placebo (p = 0.9) in this subgroup. Cizolirtine may be effective in primary allodynia after peripheral nerve injury, and a further trial in a larger number of such subjects is warranted.
A Comparative Study of Data Dissemination Models for VANETs

VANETs (vehicular ad hoc networks) are emerging as a new network environment for intelligent transportation systems. Many of the applications built for VANETs will depend on the data push communication model, where information is disseminated to a group of vehicles. In this paper, we present a formal model of data dissemination in VANETs and study how VANET characteristics, specifically the bidirectional mobility on well defined paths, affects the performance of data dissemination. We study the data push model in the context of TrafficView, a system we have implemented to disseminate information about the vehicles on the road. Traffic data could be disseminated using vehicles moving on the same direction, vehicles moving in the opposite direction, or vehicles moving in both directions. Our analysis as well as simulation results show that dissemination using only vehicles in the opposite direction increases the data dissemination performance significantly
C-Rel Regulates Interleukin 12 P70 Expression in Cd8+ Dendritic Cells by Specifically Inducing p35 Gene Transcription

Interleukin 12 (IL-12) is a 70-kD proinflammatory cytokine produced by antigen presenting cells that is essential for the induction of T helper type 1 development. It comprises 35-kD (p35) and 40-kD (p40) polypeptides encoded by separate genes that are induced by a range of stimuli that include lipopolysaccharide (LPS), DNA, and CD40 ligand. To date, the regulation of IL-12 expression at the transcriptional level has mainly been examined in macrophages and restricted almost exclusively to the p40 gene. Here we show that in CD8+ dendritic cells, major producers of IL-12 p70, the Rel/nuclear factor (NF)-κB signaling pathway is necessary for the induction of IL-12 in response to microbial stimuli. In contrast to macrophages which require c-Rel for p40 transcription, in CD8+ dendritic cells, the induced expression of p35 rather than p40 by inactivated Staphylococcus aureus, DNA, or LPS is c-Rel dependent and regulated directly by c-Rel complexes binding to the p35 promoter. This data establishes the IL-12 p35 gene as a new target of c-Rel and shows that the regulation of IL-12 p70 expression at the transcriptional level by Rel/NF-κB is controlled through both the p35 and p40 genes in a cell type–specific fashion.