Miracle-dz/UniFAR-FTUs huggingface dataset:
The Development of Attentional Biases for Faces in Infancy: A Developmental Systems Perspective

We present an integrative review of research and theory on major factors involved in the early development of attentional biases to faces. Research utilizing behavioral, eye-tracking, and neuroscience measures with infant participants as well as comparative research with animal subjects are reviewed. We begin with coverage of research demonstrating the presence of an attentional bias for faces shortly after birth, such as newborn infants’ visual preference for face-like over non-face stimuli. The role of experience and the process of perceptual narrowing in face processing are examined as infants begin to demonstrate enhanced behavioral and neural responsiveness to mother over stranger, female over male, own- over other-race, and native over non-native faces. Next, we cover research on developmental change in infants’ neural responsiveness to faces in multimodal contexts, such as audiovisual speech. We also explore the potential influence of arousal and attention on early perceptual preferences for faces. Lastly, the potential influence of the development of attention systems in the brain on social-cognitive processing is discussed. In conclusion, we interpret the findings under the framework of Developmental Systems Theory, emphasizing the combined and distributed influence of several factors, both internal (e.g., arousal, neural development) and external (e.g., early social experience) to the developing child, in the emergence of attentional biases that lead to enhanced responsiveness and processing of faces commonly encountered in the native environment.
Schistosomes and Microfilarial Parasites in Magellanic Penguins

Abstract The Magellanic Penguin (Spheniscus magellanicus) is native to Argentina, Chile, and the Falkland/Malvinas Islands, and is a regular winter migrant in Uruguayan and Brazilian coastal waters. The species is known to be susceptible to a variety of gastrointestinal nematodes, cestodes, trematodes, and acanthocephalans, as well as renal trematodes and pulmonary nematodes. Schistosomes (Platyhelminthes, Trematoda, Schistosomatidae) and microfilariae (Nematoda, Secernentea, Onchocercidae) were histologically identified in Magellanic Penguins (Spheniscus magellanicus) that died while under care at rehabilitation centers in southern Brazil. Phylogenetic analysis of the COI gene, ITS-1 region, 5.8S rRNA gene, ITS-2 region, and 28S rRNA gene sequences of the schistosome revealed that it is closely related to, but distinct from, a schistosome reported from the African Penguin (Spheniscus demersus). The schistosomes from Magellanic and African Penguins were grouped with Gigantobilharzia huronensis, Gigantobilharzia melanoidis, and Dendritobilharzia pulvurenta; however, the lack of a clearly monophyletic origin precludes determining their genus. The incidental discovery of novel parasites during a study that did not specifically aim to investigate the occurrence of helminths underscores the value of histopathological examination as an exploratory diagnostic approach.
Management of mineral and bone disorders in renal transplant recipients

The management of post‐transplantation bone disease is a complex problem that remains under‐appreciated in clinical practice. In these patients, pre‐existing metabolic bone disorder is further impacted by the use of immunosuppressive medications (glucocorticoids and calcineurin‐inhibitors), variable post‐transplantation renal allograft function and post‐transplantation diabetes mellitus. The treatment of post‐transplantation bone loss should begin pre‐transplantation. All patients active on transplant waiting lists should be screened for bone disease. Patients should also be encouraged to take preventative measures against osteoporosis such as regular weight‐bearing exercise, smoking cessation and reducing alcohol consumption. Biochemical abnormalities of disordered mineral metabolism should be corrected prior to transplantation wherever possible, and because these abnormalities commonly persist, post transplant hypophosphatemia, persistent hyperparathyroidism and low vitamin D levels should be regularly monitored and treated. Bone loss is greatest in the first 6–12 months post‐transplantation, during which period any intervention is likely to be of greatest benefit. There is strong evidence that bisphosphonates prevent post‐transplantation bone loss; however, data are lacking that this clearly extends to a reduction in fracture incidence. Denosumab is a potential alternative to vitamin D receptor agonists and bisphosphonates in reducing post‐transplantation bone loss; however, further studies are needed to demonstrate its safety in patients with a significantly reduced estimated glomerular filtration rate. Clinical judgement remains the cornerstone of this complex clinical problem, providing a strong rationale for the formation of combined endocrinology and nephrology clinics to treat patients with Chronic Kidney Disease‐Mineral and Bone Disorder, before and after transplantation.
Resilience to aging in the regeneration‐capable flatworm Macrostomum lignano

Animals show a large variability of lifespan, ranging from short‐lived as Caenorhabditis elegans to immortal as Hydra. A fascinating case is flatworms, in which reversal of aging by regeneration is proposed, yet conclusive evidence for this rejuvenation‐by‐regeneration hypothesis is lacking. We tested this hypothesis by inducing regeneration in the sexual free‐living flatworm Macrostomum lignano. We studied survival, fertility, morphology, and gene expression as a function of age. Here, we report that after regeneration, genes expressed in the germline are upregulated at all ages, but no signs of rejuvenation are observed. Instead, the animal appears to be substantially longer lived than previously appreciated, and genes expressed in stem cells are upregulated with age, while germline genes are downregulated. Remarkably, several genes with known beneficial effects on lifespan when overexpressed in mice and C. elegans are naturally upregulated with age in M. lignano, suggesting that molecular mechanism for offsetting negative consequences of aging has evolved in this animal. We therefore propose that M. lignano represents a novel powerful model for molecular studies of aging attenuation, and the identified aging gene expression patterns provide a valuable resource for further exploration of anti‐aging strategies.
A Better View Over Titan Drainage Networks Through RGB Fusion of Cassini SAR Images

We present a simple method to enhance the view of Titan drainage networks, thus allowing extracting relevant hydrological parameters. The method uses RGB fusion of three Cassini synthetic aperture radar images acquired at different times, and is tested on one drainage network. Comparison with previous studies of the same network shows an increase in all the measured parameters. The present results help constrain previous estimates of erosion times, terrain, and tectonic models for the area and indicate that, whenever possible, geomorphological inference from drainage network geometry should be drawn on multiply sampled scenes.
Statin-induced liver injury in an area endemic for hepatitis B virus infection: risk factors and outcome analysis.

AIMS Statin-induced liver injury (SILI) is quite rare, but may be severe. Little is known about the impact of chronic hepatitis B infection (CHBI) on SILI. We aimed to investigate the risk factors and outcome of SILI, with special reference to its interaction with CHBI. METHODS Patients with SILI were recruited from our hospital, and three-to-one drug-matched controls were randomly selected. The clinical data of the patients were then compared. RESULTS A total of 108 patients with SILI and 324 controls were enrolled. The patients with SILI were both older and had a higher statin dose than the controls. There was no predilection of liver injury associated with the seven available statins. Among the SILI patients, there was no statistical difference between the baseline and peak liver enzyme tests, and latency and severity between hepatitis B carriers (n = 16) and non-carriers (n = 92). High dose of statin and age were the two independent risk factors of SILI (OR and 95% CI: 1.93, 1.08-3.35, P = 0.025, and 1.73, 1.07-2.80, P = 0.027, respectively). Permanent discontinuation of statin was noted in 50 (46.3%) patients with SILI due to severe SILI or recurrent hepatotoxicity after rechallenge of other statins. CONCLUSION High dose of statin and old age may increase patient susceptibility to SILI; however, CHBI and abnormal baseline liver tests are not risk factors of SILI. Nonetheless, SILI is still worthy of notice, because nearly half of the overt cases discontinued statin treatment due to severe hepatotoxicity in this study.
The Mediation of Suffering and the Vision of a Cosmopolitan Public

In this article, the author argues that if researchers wish to move toward a “global village” with cosmopolitan values, then they need to examine critically the discourses and practices by which global information flows invite the individual spectator to be a public actor in the contexts of her or his everyday life. In the light of empirical analysis, the author presents a hierarchical typology of news stories on distant suffering that consists of adventure, emergency, and ecstatic news, and she examines the two broad ethical norms that inform these types of news: communitarianism and cosmopolitanism. The possibility for cosmopolitanism, the author concludes, lies importantly (but not exclusively) in the ways in which television tells the stories of suffering, inviting audiences to care for and act on conditions of human existence that go beyond their own communities of belonging.
OF THE EXPERIMENTAL ANALYSIS OF BEHAVIOR CHOICE AND REINFORCEMENT DELAY

Previous studies of choice between two delayed reinforcers have indicated that the relative immediacy of the reinforcer is a major determinant of the relative frequency of responding. Parallel studies of choice between two interresponse times have found exceptions to this generality. The present study looked at the choice by pigeons between two delays, one of which was always four times longer than the other, but whose absolute durations were varied across conditions. The results indicated that choice is not uniquely determined by the relative immediacy of reinforcement, but that absolute delays are also involved. Models for concurrent chained schedules appear to be more applicable to the present data than the matching relation; however, these too failed to predict choice for long delays.
Establishment and Evaluation of a Rat Model of Sidestream Cigarette Smoke-Induced Chronic Obstructive Pulmonary Disease

Chronic obstructive pulmonary disease (COPD) is a common cause of mortality worldwide. The current lack of an animal model that can be established within a certain time frame and imitate the unique features of the disease is a major limiting factor in its study. The present study established and evaluated an animal model of COPD that represents the early and advanced stage features using short-, middle-, and long-term sidestream cigarette smoke (CS) exposure. One hundred and nine Sprague–Dawley rats were randomly divided into 10 groups for different periods of sidestream CS exposure or no exposure (i.e., normal groups). The rats were exposed to CS from 3R4F cigarettes in an exposure chamber. Histological analysis was performed to determine pathological changes. We also conducted open-field tests, lung function evaluations, and cytokine analysis of the blood serum, bronchoalveolar lavage fluid, and lung tissue. The lung tissue protein levels, blood gases, and were also analyzed. As the CS exposure time increased, the indicators associated with oxidative stress, inflammatory responses, and airway remodeling were greater in the CS exposure groups than in the normal group. At 24 and 36 weeks, the COPD model rats displayed the middle- and advanced-stage features of COPD, respectively. In the 8-week CS exposure group, after the CS exposure was stopped for 4 weeks, inflammatory responses and oxidative responses were ameliorated and lung function exacerbation was reduced compared with the 12-week CS exposure group. Therefore, we established a more adequate rat model of sidestream CS induced COPD, which will have great significance for a better understanding of the pathogenesis of COPD and drug effectiveness evaluation.
Non-Shannon inequalities in the entropy vector approach to causal structures

A causal structure is a relationship between observed variables that in general restricts the possible correlations between them. This relationship can be mediated by unobserved systems, modelled by random variables in the classical case or joint quantum systems in the quantum case. One way to differentiate between the correlations realisable by two different causal structures is to use entropy vectors, i.e., vectors whose components correspond to the entropies of each subset of the observed variables. To date, the starting point for deriving entropic constraints within causal structures are the so-called Shannon inequalities (positivity of entropy, conditional entropy and conditional mutual information). In the present work we investigate what happens when non-Shannon entropic inequalities are included as well. We show that in general these lead to tighter outer approximations of the set of realisable entropy vectors and hence enable a sharper distinction of different causal structures. Since non-Shannon inequalities can only be applied amongst classical variables, it might be expected that their use enables an entropic distinction between classical and quantum causal structures. However, this remains an open question. We also introduce techniques for deriving inner approximations to the allowed sets of entropy vectors for a given causal structure. These are useful for proving tightness of outer approximations or for finding interesting regions of entropy space. We illustrate these techniques in several scenarios, including the triangle causal structure.
Intracranial high frequency activity reveals that valence representations throughout the human cortex and medial temporal lobe are modulated by reward expectation

During reinforcement learning, it is thought that subjects alter their decisions by integrating information about outcome valence and reward expectation (Rescorla and Wagner, 1972; Sutton and Barto, 1990). Recent work has shown that outcome valence is ubiquitously represented throughout the human brain (Vickery et al., 2011), however, the extent to which these widespread valence representations represent learning signals that are modulated by reward expectation is not known. In this study, we obtained intracranial electroencephalography (iEEG) recordings from the cortex and medial temporal lobe (MTL) of 39 patients with drug-refractory epilepsy as they performed a two-alternative probability learning task. Using high-frequency activity (HFA, 70-200 Hz) as an indicator of local firing rates, we identified putative learning signals as neural signals that were modulated by outcome valence and reward expectation. Whereas functional neuroimaging studies have traditionally identified expectation-modulated valence signals in regions that receive prominent inputs from dopaminergic neurons (e.g. ventral striatum, medial frontal cortex), our analysis of HFA from 4,306 electrodes revealed that such signals are widely represented throughout the human brain, and were frequently observed in regions that receive sparse dopaminergic inputs (e.g., occipital, temporal and parietal). These results provide electrophysiological support for the emerging view that reinforcement learning is driven by widespread learning signals throughout the human brain.
Impaired thrombolytic status predicts adverse cardiac events in patients undergoing primary percutaneous coronary intervention

Summary Antithrombotic medications reduce thrombosis but increase bleeding. Identification of ST-elevation myocardial infarction (STEMI) patients at risk of recurrent thrombosis could allow targeted treatment with potent antithrombotic medications, with less potent agents in others, to reduce bleeding. Conventional platelet function tests assess platelet reactivity only, yet there is increasing evidence that endogenous thrombolytic potential determines outcome following thrombus initiation. We investigated whether assessing both platelet reactivity and endogenous thrombolysis, could identify STEMI patients at high-risk of recurrent thrombotic events. Thrombotic status was assessed in STEMI patients, before and after primary percutaneous coronary intervention (PPCI), at discharge and at 30 days; with 12 months’ followup. The time to form an occlusive thrombus under high shear (occlusion time, OT), and time to restore flow by endogenous thrombolysis (lysis time, LT) was measured using the point-of-care Global Thrombosis Test (GTT) in the cardiac catheterisation laboratory. Impaired endogenous thrombolysis (prolonged LT ≥ 3000 s), seen in 13 % patients pre-PPCI, was related to major adverse cardiac events, MACE (HR: 3.31, 95 %CI: 1.02–10.78, p = 0.045), driven by cardiovascular death (HR: 4.17, 95 %CI: 0.99–17.51, p = 0.05). Enhanced (rapid) endogenous thrombolysis (LT < 1000 s) was associated with spontaneous reperfusion, ST-segment resolution and Thrombolysis In Myocardial Infarction 3 flow pre-PPCI. Baseline OT was shorter in those with MACE (especially recurrent myocardial infarction and stroke) than those without (253 ± 150 s vs 354 ± 134 s, p=0.017). Endogenous thrombolysis, when impaired, is associated with increased cardiovascular risk, and when enhanced, with spontaneous reperfusion. Endogenous thrombolysis may be a novel target for pharmacological intervention, and allow targeting of potent antithrombotic medications to high-risk patients.
Social-cognitive theories for predicting physical activity behaviours of employed women with and without young children

Chronic disease interventions for women have been understudied in the workplace domain. Understanding the role of cognitions in individual behaviour can help motivate change and suggest directions for achieving improvements in health. The purpose of this study was to identify psychosocial constructs and social-cognitive theories [e.g. Transtheoretical model (TTM), Theory of Planned Behaviour (TPB), Protection Motivation Theory (PMT) and Social Cognitive Theory (SCT)] that are most salient for explaining physical activity behaviour among employed women (n = 1183). Demographic information, and social-cognitive measures related to physical activity, intention and behaviours (e.g. stage of change, energy expenditure) were assessed. A series of multiple regression analyses predicting intention, energy expenditure and stage of change were conducted separately for: (1) women with young children (n = 302), and (2) women without young children (n = 881) for each of the respective social-cognitive theories. Although taken as a whole the results were relatively similar between the two sub-groups of women for each of the socio-cognitive theories examined in this study, differences were observed in the relative contributions of the theoretical constructs between the two sub-groups. Results also indicate that self-efficacy and intention were the strongest predictors of behaviour among both women with and without young children. The explained variances (R2) for the theories examined in this study for different sub-groups ranged from 16 to 60%, generally reflecting what has been reported in other studies within the physical activity domain. The results of this study could be useful in guiding future research and in designing physical activity intervention programs for these specific population groups. Integrating approaches of individual lifestyle change while addressing issues related to creating supportive environments for women in various life stages is a suggested strategy for future work in this area.
Accuracy of the Whooley questions and the Edinburgh Postnatal Depression Scale in identifying depression and other mental disorders in early pregnancy

Background There is limited evidence on the prevalence and identification of antenatal mental disorders. Aims To investigate the prevalence of mental disorders in early pregnancy and the diagnostic accuracy of depression-screening (Whooley) questions compared with the Edinburgh Postnatal Depression Scale (EPDS), against the Structured Clinical Interview DSM-IV-TR. Method Cross-sectional survey of women responding to Whooley questions asked at their first antenatal appointment. Women responding positively and a random sample of women responding negatively were invited to participate. Results Population prevalence was 27% (95% CI 22–32): 11% (95% CI 8–14) depression; 15% (95% CI 11–19) anxiety disorders; 2% (95% CI 1–4) obsessive–compulsive disorder; 0.8% (95% CI 0–1) post-traumatic stress disorder; 2% (95% CI 0.4–3) eating disorders; 0.3% (95% CI 0.1–1) bipolar disorder I, 0.3% (95% CI 0.1–1%) bipolar disorder II; 0.7% (95% CI 0–1) borderline personality disorder. For identification of depression, likelihood ratios were 8.2 (Whooley) and 9.8 (EPDS). Diagnostic accuracy was similar in identifying any disorder (likelihood ratios 5.8 and 6). Conclusions Endorsement of Whooley questions in pregnancy indicates the need for a clinical assessment of diagnosis and could be implemented when maternity professionals have been appropriately trained on how to ask the questions sensitively, in settings where a clear referral and care pathway is available. Declaration of interest L.M. H. chaired the National Institute for Health and Care Excellence CG192 guidelines development group on antenatal and postnatal mental health in 2012–2014.
An attack on science? Media use, trust in scientists, and perceptions of global warming

There is a growing divide in how conservatives and liberals in the USA understand the issue of global warming. Prior research suggests that the American public’s reliance on partisan media contributes to this gap. However, researchers have yet to identify intervening variables to explain the relationship between media use and public opinion about global warming. Several studies have shown that trust in scientists is an important heuristic many people use when reporting their opinions on science-related topics. Using within-subject panel data from a nationally representative sample of Americans, this study finds that trust in scientists mediates the effect of news media use on perceptions of global warming. Results demonstrate that conservative media use decreases trust in scientists which, in turn, decreases certainty that global warming is happening. By contrast, use of non-conservative media increases trust in scientists, which, in turn, increases certainty that global warming is happening.