Miracle-dz/UniFAR-FTUs huggingface dataset:
Mucormycosis of maxilla following tooth extraction in immunocompetent patients: Reports and review

Mucormycosis is a rare, fulminant, rapidly spreading fungal infection, which usually affects patient with underlying immune deficiency. If not managed promptly, the disease is characterized by progressive necrosis and is often fatal. A review of English literature shows that only fourteen cases of mucormycosis have been reported after tooth extraction. This paper highlights two cases of mucormycosis subsequent to tooth extraction in healthy adult patients. This first patient presented with an oroantral fistula and extensive maxillary necrosis. Whereas the second case was localized and presented as non-healing extraction socket with alveolar necrosis. This adds two more cases of this rare and serious complication of tooth extraction, to the present literature. Key words:Fungal, infection, zygomycosis, exodontia, complication, jaw, necrosis.
Compensation plans for single- and multi-product salesforces: an application of the Holmstrom-Milgrom model

The agency theory approach to understanding salesforce compensation plans is modified to incorporate the intratemporal nature of the salesperson's effort-rate decision, i.e., the decision about the effort-rate at any given point in time potentially depends upon the sales performance up to that point in time in the accounting period. Under the assumptions considered in this paper, Holmstrom and Milgrom (1987) have shown that the optimal compensation plan is linear in total sales over the accounting period. The comparative statics results obtained here corroborate most of the corresponding results in the salesforce compensation literature; moreover, we derive many additional results not available in the literature. It is demonstrated that the commission income as a fraction of total compensation goes up with an increase in the effectiveness of the sales-effort or an increase in base sales. On the other hand, the salary component of the total compensation goes up with increases in uncertainty, absolute risk .
Does the composition of public expenditure affect economic growth? Evidence from the Swiss case

In the light of tightening budget constraints caused by the recent financial and economic crisis and population ageing, it has become increasingly important to explore which portfolio of public expenditure generates economic growth. This article, therefore, estimates the growth effects of the composition of public expenditure for the Swiss case. One main finding is that public expenditures on transport infrastructure, education and administration foster growth. As nonhigh-quality data, which can bias least square estimators, are pervasive in economics, statistically robust estimation methods are applied.
Abrogation of Lupus Nephritis in Somatic Hypermutation–Deficient B6.MRL-Faslpr/J Mice

Systemic lupus erythematosus (SLE) is an autoimmune disease posing threats to multiple organs in the human body. As a typical manifestation of SLE, lupus nephritis is characterized by a series of pathological changes in glomerulus as well as accumulation of pathogenic autoreactive IgG with complement in the kidney that dramatically disrupts renal functions. Activation-induced deaminase (AID), which governs both somatic hypermutation (SHM) and class-switch recombination (CSR), has been shown to be essential for the regulation of SLE. However, the relative contributions of SHM and CSR to SLE pathology have not been determined. Based on the available AIDG23S mice, we successfully established an B6.AIDG23SMRL-Faslpr/J mouse model, in which SHM is specifically abolished, although CSR is largely unaffected. We found that the abrogation of SHM effectively alleviated SLE-associated histopathological alterations, such as expansion of the mesangial matrix and thickening of the basement membrane of Bowman’s capsule as well as infiltration of inflammatory cells. Compared with SLE mice, B6.AIDG23SMRL-Faslpr/J mice exhibited decreased proteinuria, blood urea nitrogen, and creatinine, indicating that the loss of SHM contributed to the recovery of renal functions. As a consequence, the life span of those SHM-deficient B6.MRL-Faslpr/J mice was extended. Together, we provide direct evidence pinpointing a vital role of SHM in the control of SLE development.
Rapid killing of human neutrophils by the potent activator phorbol 12‐myristate 13‐acetate (PMA) accompanied by changes different from typical apoptosis or necrosis

To elucidate the relationship between activation of neutrophils and their subsequent death, the effect of phorbol 12‐myristate 13‐acetate (PMA), a potent activator of neutrophils, was examined. PMA‐treated neutrophils showed morphological changes quite different from those of typical apoptosis or necrosis. After fusion of the lobate nucleus, nuclear contents of chromatin uniformly decreased in compactness and soon after the nuclear envelope was broken. Even at this stage, cytoplasmic organelles did not undergo degeneration. Membrane permeability began increasing at 3 h of incubation with PMA, subsequent to nuclear change. Conventional agarose gel electrophoresis and pulsed field gel electrophoresis of DNA from PMA‐treated neutrophils revealed no DNA degradation products smaller than 300 kbp. PKC inhibitors, staurosporine and H‐7, prevented cytotoxicity by PMA. Furthermore, antioxidants, thiourea, dimethylthiourea, pyrrolidinethiocarbamate, and N‐acetyl‐L‐cysteine, but not superoxide dismutase, were also active in preventing PMA cytotoxicity, suggesting that cell suicide resulting from PMA treatment is due to oxygen radicals, especially the hydroxyl radical. A certain population of neutrophils phagocytosing opsonized zymosan also showed changes similar to those observed in PMA‐treated cells.
Substitution of nevirapine, efavirenz, or abacavir for protease inhibitors in patients with human immunodeficiency virus infection.

BACKGROUND We assessed the strategy of substituting nevirapine, efavirenz, or abacavir for a protease inhibitor in patients infected with human immunodeficiency virus type 1 (HIV-1) in whom virologic suppression had been achieved. METHODS We randomly assigned 460 adults who were taking two nucleoside reverse-transcriptase inhibitors and at least one protease inhibitor and whose plasma HIV-1 RNA levels had been less than 200 copies per milliliter for at least the previous six months to switch from the protease inhibitor to nevirapine (155 patients), efavirenz (156), or abacavir (149). The primary end point was death, progression to the acquired immunodeficiency syndrome, or an increase in HIV-1 RNA levels to 200 copies or more per milliliter. RESULTS At 12 months, the Kaplan-Meier estimates of the likelihood of reaching the end point were 10 percent in the nevirapine group, 6 percent in the efavirenz group, and 13 percent in the abacavir group (P=0.10 according to an intention-to-treat analysis). HIV-1 RNA could be amplified in 21 of the 29 patients in whom virologic failure developed during treatment with study medication (72 percent), and resistance mutations to the study medication and to at least one of the nucleoside reverse-transcriptase inhibitors in the regimen that failed were detected in all but 1 of the 21 patients. Twenty-three of the 29 patients with virologic failure during treatment with study medication had received prior suboptimal therapy with nucleoside reverse-transcriptase inhibitors. Fewer patients in the abacavir group (6 percent) than in the nevirapine group (17 percent) or the efavirenz group (17 percent) discontinued the study medication because of adverse events (P=0.01). The proportion of patients with fasting lipid levels warranting therapeutic intervention decreased significantly in the abacavir group, but the prevalence of clinical lipodystrophy did not change significantly in the three groups. CONCLUSIONS When therapy was switched from a protease inhibitor to nevirapine, efavirenz, or abacavir in patients with virologic suppression, there was a trend toward a higher rate of virologic failure among those given abacavir.
Evaluating the Productivity Performance of Agricultural Enterprises in Ireland using a Multiple Output Distance Function Approach

This paper uses a distance function approach to measure and decompose productivity growth of Irish agriculture between 1984 and 2000 for four principal farming systems. The technology used by each system is found to be sufficiently different as to warrant a system-by-system approach. The overall rate of productivity growth in Irish agriculture is found to be just over 1% for this period, but there are significant differences between systems. Sheep systems had the highest rate of productivity growth followed by dairy and tillage. Productivity in cattle farms fell during this period although there is evidence that this trend has been reversed in more recent years.
CORPORATE BANKRUPTCIES, LIQUIDATION COSTS AND THE ROLE OF BANKS

This paper develops a reputation model to discuss the role of banks in the corporate bankruptcy process. Financially distressed firms either default on their current obligations or liquidate themselves voluntarily. Banks, who interact repeatedly in the debt market, either reduce the obligations of troubled firms or pursue liquidation. The strategy of banks is determined by a trade-off between acquiring a reputation for being tough against financially distressed firms (but incurring liquidation costs) and reducing firms' obligations so as to increase the proportion of repayment (but weakening the position against future defaults). The model shows that small firms are more likely to be liquidated when they are in financial distress than larger firms. Copyright 1996 by Blackwell Publishers Ltd and The Victoria University of Manchester
An empirical investigation of asset pricing with temporally dependent preference specifications

Using a simulated method of moments approach, the author evaluates a representative consumer asset pricing model in which the consumer is assumed to have time nonseparable preferences of several forms. Examining the model's implications for several moments of asset returns, he finds evidence for the local substitution of consumption with habit formation occurring over longer periods of time. The interaction between these two effects is important. The author also shows that, when accounting for sampling error, a model with local substitution and long-run habit persistence is consistent with the Hansen and Jagannathan (1991) bounds. Copyright 1995 by The Econometric Society.
Preparation and evaluation of biodegradable polymeric systems for the intra‐articular delivery of drugs

Colloidal suspensions of four biodegradable polymers, polylactic acid (PLA), polybutylcyanoacrylate (PBCA), gelatin (PG) and albumin (PA) were prepared within the size range 1–10 μm. In‐vivo biocompatibility tests with synovial tissues were carried out to assess the irritancy of the polymers following intra‐articular injection into rabbit knee joints. PLA, PBCA and PG were found to cause joint inflammation whereas PA was well tolerated by the tissues. PA microspheres may provide a means of sustaining the release and reducing the rate of clearance of drugs from the knee joint.
Modeling Discourse Coherence for the Automated Scoring of Spontaneous Spoken Responses

This study describes an approach for modeling the discourse coherence of spontaneous spoken responses in the context of automated assessment of non-native speech. Although the measurement of discourse coherence is typically a key metric in human scoring rubrics for assessments of spontaneous spoken language, little prior research has been done to assess a speaker’s coherence in the context of automated speech scoring. To address this, we ﬁrst present a corpus of spoken responses drawn from an assessment of English proﬁciency that has been annotated for discourse coherence. When adding these discourse annotations as features to an automated speech scoring system, the accuracy in predicting human proﬁciency scores is improved by 7.8% relative, thus demonstrating the effectiveness of including coherence information in the task of automated scoring of spon-taneous speech. We further investigate the use of two different sets of features to automatically model the coherence of spon-taneous speech, including a set of features originally designed to measure text complexity and a set of surface-based features describing the speaker’s use of nouns, pronouns, conjunctions, and discourse connectives in the spoken response. Additional experiments demonstrate that an automated speech scoring sys-tem can beneﬁt from coherence scores that are generated automatically using these feature sets.
Participants' Strategy in Crowd-Based Design Contests - A Prospect Theory Perspective

Using crowd$based contests to acquire creative desi gns is increasingly popular. In this study, I examine how client$provided information in design contests affect participants’ strategy and contest submissions. In these contests, clients often provide examples of designs that they like, thereby signaling their design preference. Using prospect theory, I relate participants’ contest payoffs and cost considerations to the extent that they deviate their submissions from client$provided exam ples. Results from a banner ad design contest show that participants (i) deviate their designs more from clients’ examples when the examples’ quality is lower, and when the examples are relatively similar, and (ii) submit designs that are more distinctive in contests when they deviate from clients’ examples. These results indicate that participants do not always seek to win contests by aligning their submissions to clients’ preference. Instead, participants’ strategy also depends on other benefits of contest participation and their preference to minimize participation costs.
Eliciting Positive Emotion through Affect-Sensitive Dialogue Response Generation: A Neural Network Approach

An emotionally-competent computer agent could be a valuable assistive technology in performing various affective tasks. For example caring for the elderly, low-cost ubiquitous chat therapy, and providing emotional support in general, by promoting a more positive emotional state through dialogue system interaction. However, despite the increase of interest in this task, existing works face a number of shortcomings: system scalability, restrictive modeling, and weak emphasis on maximizing user emotional experience. In this paper, we build a fully data driven chat-oriented dialogue system that can dynamically mimic affective human interactions by utilizing a neural network architecture. In particular, we propose a sequence-to-sequence response generator that considers the emotional context of the dialogue. An emotion encoder is trained jointly with the entire network to encode and maintain the emotional context throughout the dialogue. The encoded emotion information is then incorporated in the response generation process. We train the network with a dialogue corpus that contains positive-emotion eliciting responses, collected through crowd-sourcing. Objective evaluation shows that incorporation of emotion into the training process helps reduce the perplexity of the generated responses, even when a small dataset is used. Subsequent subjective evaluation shows that the proposed method produces responses that are more natural and likely to elicit a more positive emotion.
Is magnetic resonance imaging helpful in detecting significant prostate cancer in patients with haematospermia, normal prostate specific antigen level and digital rectal examination. A single institution, observational, and retrospective study in a United Kingdom hospital

Introduction Haematospermia is an uncommon clinical condition that may be associated with prostate cancer. The optimal investigation of haematospermia is unknown. The aim of this study was to investigate haematospermia as a presenting symptom of significant pathology and to assess the diagnostic value of magnetic resonance imaging (MRI). Material and methods Patient and treatment parameters were collected from a practice cohort of men referred to a urology center presenting with haematospermia. We used a multivariate logistic regression model to test the independent significance of MRI in detecting prostate cancer (PCa) after adjusting for other known predictors of PCa detection. Results A total of 125 men (median age 58 years) were evaluated between 2012–2015. In the univariate and multivariate logistic regression model MRI was a significant predictor of PCa diagnosis after adjusting for age, prostate specific antigen (PSA) and digital rectal examination (DRE) results (Odds Ratio (OR) 14.15, p = 0.001). Of 107 patients who underwent MRI prostate imaging, 31 (28.9%) had reports suspicious of PCa. In 26 patients, other benign conditions were detected on MRI. PCa was detected in 12 (25.5%) of the 47 men (median age 61 years; range 43 to 85) who underwent prostate biopsies. Eight (17%) of these patients had Gleason ≥7 grade cancer. The persistence of haematospermia was not an independent predictor of cancer diagnosis (OR 0.20, p = 0.15). Conclusions PCa is not commonly associated with haematospermia. MRI seems to be improving detection rate of a significant PCa, particularly in patients presenting with haematospermia and normal PSA levels and DRE examination. Duration of haematospermia does not predict the presence of PCa.
Mechanical responsiveness of the endothelial cell of Schlemm's canal: scope, variability and its potential role in controlling aqueous humour outflow

Primary open-angle glaucoma is associated with elevated intraocular pressure, which in turn is believed to result from impaired outflow of aqueous humour. Aqueous humour outflow passes mainly through the trabecular meshwork (TM) and then through pores formed in the endothelium of Schlemm's canal (SC), which experiences a basal-to-apical pressure gradient. This gradient dramatically deforms the SC endothelial cell and potentially contributes to the formation of those pores. However, mechanical properties of the SC cell are poorly defined. Using optical magnetic twisting cytometry and traction force microscopy, here we characterize the mechanical properties of primary cultures of the human SC cell, and for the first time, the scope of their changes in response to pharmacological agents that are known to modulate outflow resistance. Lysophosphatidic acid, sphingosine-1-phosphate (S1P) and thrombin caused an increase in cell stiffness by up to 200 per cent, whereas in most cell strains, exposure to latrunculin A, isoproterenol, dibutryl cyclic-AMP or Y-27632 caused a decrease in cell stiffness by up to 80 per cent, highlighting that SC cells possess a remarkably wide contractile scope. Drug responses were variable across donors. S1P, for example, caused 200 per cent stiffening in one donor strain but only 20 per cent stiffening in another. Isoproterenol caused dose-dependent softening in three donor strains but little or no response in two others, a finding mirrored by changes in traction forces and consistent with the level of expression of β2-adrenergic receptors. Despite donor variability, those drugs that typically increase outflow resistance systematically caused cell stiffness to increase, while in most cases, those drugs that typically decrease outflow resistance caused cell stiffness to decrease. These findings establish the endothelial cell of SC as a reactive but variable mechanical component of the aqueous humour outflow pathway. Although the mechanism and locus of increased outflow resistance remain unclear, these data suggest the SC endothelial cell to be a modulator of outflow resistance.
Fluorodeoxyglucose–Positron Emission Tomography Imaging Versus Sentinel Node Biopsy in the Primary Staging of Melanoma Patients

BACKGROUND Positron emission tomography (PET) imaging is superior to conventional techniques for the evaluation of patients with stage III and stage IV cutaneous melanoma. Several studies have highlighted the advantages of this noninvasive technique for the assessment of lymph node involvement. OBJECTIVE To compare PET imaging with sentinel node biopsy for primary staging of cutaneous melanoma and to discuss the technical limitations of PET scanning. METHODS Twenty-five consecutive patients with a histologic diagnosis of melanoma with a Breslow thickness equal or greater to 1 mm underwent a preoperative PET to assess lymph node involvement. RESULTS Sentinel node biopsy and PET showed a sensitivity of 100% and 22%, respectively, in the identification of lymph node metastases. CONCLUSION PET is not a sensitive technique for the primary staging of cutaneous melanoma.
Outbreaks of adenoviral gizzard erosion in slaughtered broiler chickens in Japan

Gizzard erosion in broiler chickens was investigated at 18 slaughterhouses in Japan. The condition was observed in 13 of them, and adenoviral gizzard erosion (AGE) was diagnosed histologically, immunohistochemically and virologically in the eroded gizzards from nine of these 13. The antigen-positive intranuclear inclusion body of group 1 fowl adenovirus was observed in the epithelial cells of the affected gizzards, and fowl adenoviruses were isolated from the lesions. In two of the slaughterhouses the total weights of the gizzards disposed of in three years were 3590 kg (0.40 per cent of the gizzards inspected) and 2880 kg (0.19 per cent). Sixteen of the 19 outbreaks of gizzard erosion on 15 farms that were confirmed in three of the slaughterhouses, including the previous two slaughterhouses, were diagnosed as AGE, and the condition was suspected in the other three outbreaks. Most of the adenoviruses isolated were identified as serotype-1 by PCR-restriction fragment length polymorphism. No apparent clinical signs were observed in any of the affected flocks.
Trends in Authorship Characteristics in The American Journal of Sports Medicine, 1994 to 2014

Background: Trends in author qualifications, the number of authors per article, and the internationalization of author groups in sports medicine journals have not been widely investigated. Purpose: To examine trends in authorship characteristics in a single prominent sports medicine journal. Study Design: Systematic review. Methods: Articles published in The American Journal of Sports Medicine (AJSM) in 1994, 2004, and 2014 were reviewed. For each article, the academic degree(s) of the first and last author, the total number of authors, the country of the author group, and academic institution status were recorded. Results: A total of 708 articles met the inclusion criteria: 129 in 1994, 244 in 2004, and 335 in 2014. There were significant differences in the proportion of first authors with an MD degree (80% in 1994, 75% in 2004, 67% in 2014; P = .01), a dual MD/PhD degree (4.7% in 1994, 6.2% in 2004, 9.3% in 2014; P < .001), and a bachelor’s degree (0% in 1994, 0% in 2004, 3.9% in 2014; P < .001). The proportion of last authors with an MD/PhD significantly increased over the 2 decades studied (7% in 1994, 13% in 2004, 17% in 2014; P = .01). The mean number of authors per article also significantly increased (3.8 in 1994, 4.3 in 2004, 5.8 in 2014; P < .0001). The proportion of articles published by an international group and the proportion of articles published by an academic institution increased over the 20-year span as well (both P < .0001). Conclusion: Within the past 2 decades, there has been a significant increase in the average number of authors per article in AJSM, as well as a higher proportion of international groups and academic institutions publishing in the journal. More nonphysicians are publishing in AJSM, with a significantly higher percentage of first authors with a bachelor’s degree as their highest degree. This is likely due to a combination of a general increased interest in research as well as increased competition among medical students. These factors have likely led to larger research groups and thus a significantly higher average number of authors per article.