Miracle-dz/UniFAR-FTUs huggingface dataset:
Surgical and postoperative complications associated with tibial plateau leveling osteotomy in dogs with cranial cruciate ligament rupture: 397 cases (1998-2001).

OBJECTIVE To identify surgical and postoperative complications of tibial plateau leveling osteotomy (TPLO) in dogs with rupture of the cranial cruciate ligament (CCL) and compare their incidence with those reported in the literature for other commonly performed CCL stabilization procedures. DESIGN Retrospective study. ANIMALS 346 dogs undergoing 397 TPLO procedures. PROCEDURE Medical records of dogs undergoing 563 consecutive TPLO procedures were reviewed. Complications were recorded and assigned to groups on the basis of the period during which the complication was observed. RESULTS 397 TPLOs met the criteria for inclusion in the study. Complications (n = 136) were recorded in 113 of the 397 (28%) procedures. Multiple complications developed in 10 dogs. In 19 dogs, a second surgery was performed to manage complications. Development of a complication after surgery was not associated with age or body weight of the dog, tibial plateau angle prior to stifle joint surgery, or experience of the surgeon. Factors significantly associated with complications were breed and performance of an arthrotomy concomitantly with TPLO. CONCLUSIONS AND CLINICAL RELEVANCE TPLO was associated with development of numerous complications, some of which required surgical correction. Most complications resolved with nonsurgical treatment. Several complications were unique to the TPLO procedure because of the surgical technique and implants required. Although TPLO was associated with a greater number of complications than other CCL stabilization methods, the incidence of major complications was similar.
On the sensitivity of droplet size relative dispersion to warm cumulus cloud evolution

Relative dispersion (ε), defined as the ratio between cloud droplet size distribution width (σ) and cloud droplet average radius (〈r〉), is a key factor used to parameterize various cloud processes in global circulation models (GCMs) and bulk microphysical scheme models (BSMs). Recent studies indicate that the impact of aerosol loading (N) and atmospheric thermodynamic conditions on ε are far from fully understood. Currently, a fixed value per hydrometeor type is used in most BSMs and GCMs, which imposes significant limitations on our ability to model and predict cloud processes and their impact on the environment, on regional to global scales. In this study, we use a detailed bin microphysics single cloud model to investigate the combined impact of atmospheric thermodynamic conditions and N on ε, in warm cumulus clouds. As initial conditions, we used different lapse‐rates combined with 8 scenarios of aerosol loading, representing very clean (N = 25 cm−3) to heavily polluted (N = 1600 cm−3) conditions. Moreover, the results are analyzed per cloud evolutionary stage according to the dominance of microphysical processes. The use of this method indicated a different pattern of ε at each stage. Specifically, during the mature stage fitting of ε to rv is relatively resilient to changes in the environmental conditions. Such findings suggest a new view of the effect of aerosols on clouds, via changes in the cloud evolution patterns and a new approach to parameterization of ε based on rv, which can significantly improve the prediction of cloud processes by GCMs and BSMs.
Changes in transcriptome after in vivo exposure to ionising radiation reveal a highly specialised liver response

Purpose: To identify transcriptional gene-networks involved in the early in vivo response of liver cells to radiation exposure and improve our understanding of the molecular processes responsible for tissue radiosensitivity. Materials and methods: Transcriptome variations of liver RNA samples were measured 3 hours post-irradiation using microarray technology. The results were confirmed and extended using real-time polymerase-chain-reaction (RT-PCR). Results: We identified quantitative changes in the expression of 126 genes, most of which were observed for the first time. We show that some modifications, such as the upregulation of the cyclin-dependent kinase inhibitor 1A (Cdkn1A) gene, persisted for at least two months after the initial exposure. Other genes regulated by the transformation-related protein 53 (Trp53/p53) such as Bcl2-associated X protein (Bax) or etoposide-induced-2.4 (Ei24/PIG8) were not upregulated. Grouping differentially expressed genes into functional categories revealed that the primary response of liver cells to radiation exposure was the enhancement of oxidoreductase activity and inhibition of cell proliferation, involving cell cycle progression and apoptosis-related genes. Conclusions: The data provides evidence of gene expression modifications associated with the hepatic response to radiation exposure. One of the main differences observed with radiation-sensitive tissues such as the spleen was cell proliferation. The comparison of our data with transcriptome modifications in different biological models enabled the identification of networks of genes that might be co-regulated. Overall, our expression data revealed genes and cellular pathways that might help to improve our understanding of the molecular basis underlying tissue radiosensitivity and to identify possible targets for novel therapeutic strategies.
Human Resource Practices and Organizational Performance in SMEs in Klang Valley

This chapter discusses the relevant literature review and the framework for the research questions and research objectives which are posted in Chapter 1. To explore the past related research topic, the cross-disciplinary review of the literature is needed in order to seek accurate and adequate processes, objects, activities, and person‟s involvement (Allison, 1996). This study is an exploratory research. The conceptual framework has been modified and it is based on previous research studies conducted in other countries. This framework is applied to the Malaysian context to discuss the relationship of human resource practices and organizational performance of Malaysian SMEs with company‟s policy on innovation as a mediating factor (Pfeffer, 1994).
Isolation of “Side Population” Progenitor Cells From Healthy Arteries of Adult Mice

Objective—Circulating progenitors and stem cells have been reported to contribute to angiogenesis and arterial repair after injury. In the present study, we investigated whether the arterial wall could host permanently residing progenitor cells under physiological context. Methods and Results—Using the Hoechst-based flow cytometry method, we identified and isolated progenitor cells termed side population (SP) cells at a prevalence of 6.0±0.8% in the tunica media of adult mice aortas. Arterial SP cells expressed the ATP-binding cassette transporter subfamily G member 2, frequently present on SP cell surface, and displayed a Sca-1+ c-kit-/low Lin− CD34−/low profile. They did not form myeloid or lymphoid hematopoietic colonies after plating in methylcellulose-based medium. Importantly, cultured SP cells were able to acquire the phenotype of endothelial cells (CD31, VE-cadherin, and von Willebrand factor expression) or of smooth muscle cells (α-smooth muscle actin, calponin, and smooth muscle myosin heavy chain expression), in presence of either vascular endothelial growth factor or transforming growth factor (TGF)-β1/PDGF-BB, respectively. Moreover, they generated vascular-like branching structures, composed of both VE-cadherin+ cells and α-smooth muscle actin+ cells on Matrigel. Conclusions—In this study, we provide the first evidence to our knowledge that in the adult mice, the normal arterial wall harbors SP cells with vascular progenitor properties.
The DL-Lite Family and Relations

The recently introduced series of description logics under the common moniker 'DL-Lite' has attracted attention of the description logic and semantic web communities due to the low computational complexity of inference, on the one hand, and the ability to represent conceptual modeling formalisms, on the other. The main aim of this article is to carry out a thorough and systematic investigation of inference in extensions of the original DL-Lite logics along five axes: by (i) adding the Boolean connectives and (ii) number restrictions to concept constructs, (iii) allowing role hierarchies, (iv) allowing role disjointness, symmetry, asymmetry, reflexivity, irreflexivity and transitivity constraints, and (v) adopting or dropping the unique name assumption. We analyze the combined complexity of satisfiability for the resulting logics, as well as the data complexity of instance checking and answering positive existential queries. Our approach is based on embedding DL-Lite logics in suitable fragments of the one-variable first-order logic, which provides useful insights into their properties and, in particular, computational behavior.
Impact of Serum High Mobility Group Box 1 and Soluble Receptor for Advanced Glycation End-Products on Subclinical Atherosclerosis in Patients with Granulomatosis with Polyangiitis

The objective of this study was to evaluate whether levels of high mobility group box 1 (HMGB1) in granulomatosis with polyangiitis (GPA) patients are associated with carotid atherosclerosis, related to levels of soluble receptor for advanced glycation end-products (sRAGE) and influenced by immunosuppressive or lipid-lowering therapy. Twenty-three GPA patients and 20 controls were evaluated for HMGB1- and sRAGE levels and for carotid atherosclerosis using ultrasound to determine intima-media thickness (IMT). In vitro the effect of atorvastatin on the production of HMGB1 by lipopolysaccharide (LPS)-stimulated human umbilical vein endothelial cells (HUVEC) was assessed. Serum HMGB1 and sRAGE levels did not differ between patients and controls. A negative correlation was found between sRAGE and maximum IMT but HMGB1 and carotid IMT were not related. HMGB1 levels were reduced in GPA patients on statins and prednisolone. In vitro, atorvastatin reduced HMGB1 levels in supernatants of activated HUVEC. In conclusion, carotid IMT is inversely correlated with sRAGE levels but not with HMGB1 levels. Statins and prednisolone are associated with reduced serum HMGB1 levels and atorvastatin decreases HMGB1 release by activated HUVEC in vitro, indicating an additional anti-inflammatory effect of statins.
SemEval-2015 Task 6: Clinical TempEval

Clinical TempEval 2015 brought the temporal information extraction tasks of past TempEval campaigns to the clinical domain. Nine sub-tasks were included, covering problems in time expression identification, event expression identification and temporal relation identification. Participant systems were trained and evaluated on a corpus of clinical notes and pathology reports from the Mayo Clinic, annotated with an extension of TimeML for the clinical domain. Three teams submitted a total of 13 system runs, with the best systems achieving near-human performance on identifying events and times, but with a large performance gap still remaining for temporal relations.
Assessing Genetic Variability in Taramira (Eruca sativa Mill.) Germplasm for Enhanced Breeding Strategies

The present research was carried out to estimate the genetic variability for 13 characters among 30 different germplasm of Taramira (Eruca sativa Mill.) in a randomized block design with three replications over four artificially created environments through different dates of sowing (timely sown 17 Oct. and late sown 5 Nov.) with (Orobanche free and Orobanche infested field) i.e. timely sown, Orobanche free (E1 ), timely sown, Orobanche infested (E2 ), late sown, Orobanche free (E3 ), late sown, Orobanche infested (E4 ) at Research farm of SKN College of Agriculture, Jobner (SKNAU, Jobner) during the rabi 2022–23. Pooled Anova revealed significant differences among germplasm, environments and G×E interaction significant for all the traits except days to maturity, primary branches per plant, siliqua length (cm). Therefore, analysis of variance is carried out separately for each environment, indicated significant differences among all traits. In all four environments, the PCV>GCV value for all characters. After comparing the mean and range for yield and different yield attributing traits in all four environments, it was found that both were highest in E1 for most of the traits. The high heritability coupled with high genetic advance as percentage of mean for all four environments revealed that characteristics such as height of first branch emergence (cm), seeds per siliqua, 1000-seed weight (g) and seed yield per plant (g) had high value. As a result, they might be under the control of additive gene action. Therefore, selection for these characters will be highly responsive.
Aerosols Loading Trends and its Environmental Threats Over Cotonou-Benin.

Environmental security is totally relegated in countries of West Africa. The monitoring of the aerosols loading over Cotonou was the aim of this study. The outcome of our finding has salient links to food security, aviation and communication industry, thermal comfort and climate system of Benin. Cotonou is located on longitude 2.43°E and latitude 6.37°N. Fifteen years data were obtained from the multiangled spectro-reflectometry (MISR). The aerosol loading was monitored using analytical and statistical techniques. The aerosols retention over Cotonou was high in 2000 (69.91%), 2008 (72%) and 2013 (42.45%). This means that there is the possibility of higher rising sea levels and exposure to coastal erosion due to a twisted cloud formation.
Behavioral and Psychological Signs and Symptoms of Dementia (BPSD) in antipsychotic-naïve Alzheimer's Disease patients

Background/Objective: There were few studies identifying the natural unfolding of behavioural and psychological symptoms of dementia (BPSD) in the course of Alzheimer's disease (AD) progression in antipsychotic-naïve AD patients. This study aims to examine the specific nature of the association between BPSD in AD and the global severity of illness measured by Global Deterioration Scale(GDS) in antipsychotic-naïve AD patients in Korea. Methods: A total of 562 antipsychotics-naïve AD patients were recruited from four different groups [a geriatric mental hospital (n=145), a semi-hospitalized dementia institution (n=120), a dementia clinic (n=114) and community-dwelling dementia patients (n=183)]. BPSD exhibited by AD patients were measured using the 25-item Korean version of the BEHAVE-AD. Results: Ninety-two percent (n=517) of AD patients had at least one BPSD, while 56% (n=315) had 4 or more BPSD. Specific kinds of behavioral disturbance peak at the stages of moderate AD (GDS stage 5) or moderately severe AD (GDS stage 6). AD patients left at home without any treatment had higher frequency of BPSD than did other groups seeking treatment, although all of them were antipsychotic-naïve. Conclusion: BPSD potentially remediable to treatment were highly frequent in Korean AD patients. Health policies to meet the unmet needs of elderly Koreans are urgently needed, especially for AD patients at home without treatment.
XY99-5038 PROMOTES LONG-TERM SURVIVAL OF CULTURED RETINAL NEURONS

We have previously reported that XY99-5038, a preparation from a specific formula of Traditional Chinese Medicine, could effectively inhibit hydrogen peroxide-induced retinal cell death. In the present study, we investigated the possibility of XY99-5038 to prolong neuronal survival in a long-term retinal neuronal culture. Basic fibroblast survival factor (bFGF), a potent neurotrophic factor, was employed as comparable agent. Retinas of 0 2 days old Sprague-Dawley rats were isolated and dissociated. The cells were maintained in tissue culture for up to 9 weeks in a synthetic serum-free media. XY99-5038 (100 ng/ml) or a vehicle was added to culture every 3 4 days, starting at the first week of culturing. The number of cells were counted and compared for each time point and treatment. Cell viability was also determined by MTT assay, whereas apoptotic cell death was evaluated by the TUNEL assay. XY99-5038 treatment significantly reduced cell loss, increased cell viabil ity, and inhibited apoptosis in this long-term retinal neuronal culture. Our data also show that the protective effect of XY99-5038 is more potent than that of bFGF. Our data suggest that XY99-5038 could be beneficial to the prolongation of neuron survival.
Finite-Time Cluster Synchronization of T–S Fuzzy Complex Networks With Discontinuous Subsystems and Random Coupling Delays

This paper is concerned with the cluster synchronization in finite time for a class of complex networks with nonlinear coupling strengths and probabilistic coupling delays. The complex networks consist of several clusters of nonidentical discontinuous systems suffered from uncertain bounded external disturbance. Based on the Takagi-Sugeno (T-S) fuzzy interpolation approach, we first obtain a set of T-S fuzzy complex networks with constant coupling strengths. By developing some novel Lyapunov functionals and using the concept of Filippov solution, some new analytical techniques are established to derive sufficient conditions ensuring the cluster synchronization in a setting time. In particular, this paper extends the pinning control strategies for networks with continuous-time dynamics to discontinuous networks. Numerical simulations demonstrate that the theoretical results are effective and the T-S fuzzy approach is important for relaxed results.
SPECIFIC ANTIBODY WITHIN LYMPHOID GERMINAL CENTER CELLS OF MICE AFTER PRIMARY IMMUNIZATION WITH HORSERADISH PEROXIDASE: A LIGHT AND ELECTRON MICROSCOPIC STUDY

The appearance in mice of specific antibody within newly formed germinal centers in lymph nodes was demonstrated by light and electron microscopy after regional primary antigenic stimulation with horseradish peroxidase (HRP). Lymphoid germinal center cells containing anti-HRP antibody in the perinuclear space and in the cytoplasm were detected from 17 to 26 days after antigenic stimulation. Extracellular anti-HRP antibody within germinal centers, localized between dendritic reticular cells and lymphoid elements, could not be found before the appearance of intracellular antibody. These findings strongly suggest antibody formation by lymphoid germinal center cells. Both antigen and corresponding antibody persisted in intercellular spaces up to 35 days after primary stimulation. The concomitant presence in a given lymph node of germinal centers which are positive or negative with regard to specific antibody provide evidence in favor of monospecificity of individual centers. The mechanisms of antigen-trapping within germinal centers are discussed in the light of the present observations.
Quinoxaline 1,4-di-N-Oxides: Biological Activities and Mechanisms of Actions

Quinoxaline 1,4-di-N-oxides (QdNOs) have manifold biological properties, including antimicrobial, antitumoral, antitrypanosomal and antiinflammatory/antioxidant activities. These diverse activities endow them broad applications and prospects in human and veterinary medicines. As QdNOs arouse widespread interest, the evaluation of their medicinal chemistry is still in progress. In the meantime, adverse effects have been reported in some of the QdNO derivatives. For example, genotoxicity and bacterial resistance have been found in QdNO antibacterial growth promoters, conferring urgent need for discovery of new QdNO drugs. However, the modes of actions of QdNOs are not fully understood, hindering the development and innovation of these promising compounds. Here, QdNOs are categorized based on the activities and usages, among which the antimicrobial activities are consist of antibacterial, antimycobacterial and anticandida activities, and the antiprotozoal activities include antitrypanosomal, antimalarial, antitrichomonas, and antiamoebic activities. The structure-activity relationship and the mode of actions of each type of activity of QdNOs are summarized, and the toxicity and the underlying mechanisms are also discussed, providing insight for the future research and development of these fascinating compounds.
Circulatory limits to oxygen supply during an acute temperature increase in the Chinook salmon (Oncorhynchus tshawytscha).

This study was undertaken to provide a comprehensive set of data relevant to disclosing the physiological effects and possible oxygen transport limitations in the Chinook salmon (Oncorhynchus tshawytscha) during an acute temperature change. Fish were instrumented with a blood flow probe around the ventral aorta and catheters in the dorsal aorta and sinus venosus. Water temperature was progressively increased from 13 degrees C in steps of 4 degrees C up to 25 degrees C. Cardiac output increased from 29 to 56 ml.min(-1). kg(-1) between 13 and 25 degrees C through an increase in heart rate (58 to 105 beats/min). Systemic vascular resistance was reduced, causing a stable dorsal aortic blood pressure, yet central venous blood pressure increased significantly at 25 degrees C. Oxygen consumption rate increased from 3.4 to 8.7 mg.min(-1). kg(-1) during the temperature increase, although there were signs of anaerobic respiration at 25 degrees C in the form of increased blood lactate and decreased pH. Arterial oxygen partial pressure was maintained during the heat stress, although venous oxygen partial pressure (Pv(O(2))) and venous oxygen content were significantly reduced. Cardiac arrhythmias were prominent in three of the largest fish (>4 kg) at 25 degrees C. Given the switch to anaerobic metabolism and the observation of cardiac arrhythmias at 25 degrees C, we propose that the cascade of venous oxygen depletion results in a threshold value for Pv(O(2)) of around 1 kPa. At this point, the oxygen supply to systemic and cardiac tissues is compromised, such that the oxygen-deprived and acidotic myocardium becomes arrhythmic, and blood perfusion through the gills and to the tissues becomes compromised.
Suspended accounts in retrospect: an analysis of twitter spam

In this study, we examine the abuse of online social networks at the hands of spammers through the lens of the tools, techniques, and support infrastructure they rely upon. To perform our analysis, we identify over 1.1 million accounts suspended by Twitter for disruptive activities over the course of seven months. In the process, we collect a dataset of 1.8 billion tweets, 80 million of which belong to spam accounts. We use our dataset to characterize the behavior and lifetime of spam accounts, the campaigns they execute, and the wide-spread abuse of legitimate web services such as URL shorteners and free web hosting. We also identify an emerging marketplace of illegitimate programs operated by spammers that include Twitter account sellers, ad-based URL shorteners, and spam affiliate programs that help enable underground market diversification. Our results show that 77% of spam accounts identified by Twitter are suspended within on day of their first tweet. Because of these pressures, less than 9% of accounts form social relationships with regular Twitter users. Instead, 17% of accounts rely on hijacking trends, while 52% of accounts use unsolicited mentions to reach an audience. In spite of daily account attrition, we show how five spam campaigns controlling 145 thousand accounts combined are able to persist for months at a time, with each campaign enacting a unique spamming strategy. Surprisingly, three of these campaigns send spam directing visitors to reputable store fronts, blurring the line regarding what constitutes spam on social networks.