Miracle-dz/UniFAR-FTUs huggingface dataset:
Exploring Erikson's Psychosocial Theory of Development: Generativity and its Relationship to Paternal Identity, Intimacy, and Involvement in Childcare

This study explored the relationships among fathers' involvement in childcare, identity, intimacy, and generativity in order to understand which variables best predict variation in fathers' level of generativity. The study's major findings were that fathers' paternal identity, psychosocial identity, and psychosocial intimacy were the best overall predictors of fathers' level of generativity. Fathers' paternal identity was the best predictor of fathers' generativity. Interestingly, fathers' involvement in childcare was not a good predictor of fathers' generativity. The study's findings also give support to the assumption that development in previous psychosocial stages (i.e., identity and intimacy) are extremely important to later stages of psychosocial development (i.e., generativity). However, this assumption needs to be tested through longitudinal methods. The finding that paternal identity was a good predictor of generativity gives support for the proposition of person-role merger, in which one's investment in a role can influence development.
The role of security, privacy, usability and reputation in the development of online banking

Purpose – The purpose of this research is to analyse the influence of perceived web site security and privacy, usability and reputation on consumer trust in the context of online banking. Moreover, the paper also aims to analyse the trust‐commitment relationship since commitment is a key variable for establishing successful long‐term relationships with customers.Design/methodology/approach – The paper describes the positive effects of security and privacy, usability and reputation on consumer trust in a web site in the online banking context. Besides this, it also suggests that trust has a positive effect on consumer commitment. After the validation of measurement scales, the hypotheses are contrasted through structural modelling. Finally, the paper compares the hypothesised model with a rival one in order to test the mediating role of trust.Findings – The data showed that web site security and privacy, usability and reputation have a direct and significant effect on consumer trust in a financial services.
B cells are critical for autoimmune pathology in Scurfy mice

Significance The deficiency of regulatory T cells leads to a fatal systemic autoimmune disease in mice (Scurfy phenotype) and humans [IPEX (immune dysregulation, polyendocrinopathy, enteropathy, X-linked) syndrome]. At present it is largely unclear to what degree the different deregulated parts of the immune system contribute to the disease pathology. To understand the role of B cells and the corresponding autoantibodies produced by these cells in this fatal disease we generated B-cell–deficient Scurfy mice and show that most of the systemic autoimmune phenotypes are greatly ameliorated. Consistent with this genetic approach, therapeutic depletion of B cells resulted in a similar increase in survival and reduction in multiorgan inflammation, suggesting that B cells may be a therapeutic target to ameliorate disease pathology. Impaired regulatory T-cell function results in a severe chronic autoimmune disease affecting multiple organs in Scurfy mice and humans with the immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome. Previous studies have shown that T helper cells but not cytotoxic T cells are critical for the disease pathology. Whether this T-cell subset is responsible directly for tissue inflammation or rather indirectly via the interaction with B cells or myeloid cells is largely unknown. To study this and to identify potential therapeutic targets for this lethal disease we investigated the contribution of B cells to this complex autoimmune phenotype. We show that B cells and the production of autoantibodies plays a major role for skin, liver, lung, and kidney inflammation and therapeutic depletion of B cells resulted in reduced tissue pathology and in prolonged survival. In contrast, the absence of B cells did not impact systemic T-cell activation and hyperreactivity, indicating that autoantibody production by B cells may be a major factor for the autoimmune pathology in mice deficient for regulatory T cells.
A Poor Prognosis Subtype of HNSCC Is Consistently Observed across Methylome, Transcriptome, and miRNome Analysis

Purpose: Distant metastasis after treatment is observed in about 20% of squamous cell carcinoma of the head and neck (HNSCC). In the absence of any validated robust biomarker, patients at higher risk for metastasis cannot be provided with tailored therapy. To identify prognostic HNSCC molecular subgroups and potential biomarkers, we have conducted genome-wide integrated analysis of four omic sets of data. Experimental Design: Using state-of-the-art technologies, a core set of 45 metastasizing and 55 nonmetastasizing human papillomavirus (HPV)-unrelated HNSCC patient samples were analyzed at four different levels: gene expression (transcriptome), DNA methylation (methylome), DNA copy number (genome), and microRNA (miRNA) expression (miRNome). Molecular subgroups were identified by a model-based clustering analysis. Their clinical relevance was evaluated by survival analysis, and functional significance by pathway enrichment analysis. Results: Patient subgroups selected by transcriptome, methylome, or miRNome integrated analysis are associated with shorter metastasis-free survival (MFS). A common subgroup, R1, selected by all three omic approaches, is statistically more significantly associated with MFS than any of the single omic-selected subgroups. R1 and non-R1 samples display similar DNA copy number landscapes, but more frequent chromosomal aberrations are observed in the R1 cluster (especially loss at 13q14.2-3). R1 tumors are characterized by alterations of pathways involved in cell–cell adhesion, extracellular matrix (ECM), epithelial-to-mesenchymal transition (EMT), immune response, and apoptosis. Conclusions: Integration of data across several omic profiles leads to better selection of patients at higher risk, identification of relevant molecular pathways of metastasis, and potential to discover biomarkers and drug targets. Clin Cancer Res; 19(15); 4174–84. ©2013 AACR.
Trends in Advertising Research: A Look at the Content of Marketing-Oriented Journals from 1976 to 1985

Abstract It is important to examine periodically the outlets for advertising research to provide both producers and consumers of that research with an accurate view of topics and trends. For this paper, the content of 10 years of advertising research in six marketing/advertising journals was analyzed to determine the direction in which these journal editors, reviewers, and authors are taking the field of advertising research. Variables examined include advertising topics researched, empirical methods used, and the journal audience(s) addressed. Sample findings include a significant relationship between the journals and the topics they publish (e.g., JA published research covering a variety of topics, such as social issues, advertising practice, and advertising content, while JAR was more specialized, devoting over half of its content to advertising practice alone). JCR has significantly increased publication of advertising research over time, and significant topics of advertising research remain under-pub.
THE IMPACT OF MONITORING MECHANISMS AND MANAGEMENT INCENTIVES ON AUDITOR-CLIENT NEGOTIATIONS AROUND THE TIME OF AN INITIAL PUBLIC OFFERING

Auditor-client negotiations typically arise in the context of the incentives and monitoring of the parties involved (Gibbins et al. 2001; Gibbins et al. 2007), yet we know little about how these contextual factors influence negotiation judgments from the manager's perspective (Brown and Wright 2008; Salterio 2011). We posit that monitoring mechanisms through the negotiations process will affect managerial opportunism. Specifically, we posit that a strong audit committee overseeing financial reporting bolsters the bargaining power of the auditor (Ng and Tan 2003; Brown and Wright 2011) and thereby constrains managerial opportunism. Further, we posit that a contentious past relationship with the auditor results in less opportunistic judgments by managers, who are motivated by a desire to come to a negotiations resolution (Gibbins et al. This is in contrast to auditors, who employ more competitive strategies when faced with a contentious client (Brown-Liburd and Wright 2011), which is consistent with the auditors' professional mandate for conservatism in their pre-negotiation judgments (Antle and Nalebuff 1991). In addition, we examine whether greater opportunities to act on managerial incentives or heightened scrutiny from a variety of monitors impact opportunistic behavior in the IPO-year (Lo 2008) relative to the pre-IPO period. To test our hypotheses we use a 2 x 2 x 2 experimental factorial design with audit committee strength (strong or weak) and past auditor relationship (contentious or cooperative) manipulated between subjects, and management incentives (IPO-year) manipulated within subjects. Participants in the experiment are 137 experienced CFO/Controllers who provide pre-negotiation judgments concerning an inventory write-down issue. The findings indicate that participants propose and expect a larger inventory write-down when the audit committee is strong, when faced with a contentious past auditor relationship, and in the presence of both of these conditions. These effects are even more pronounced in the IPO-year. The results are consistent with strong monitoring mechanisms constraining client opportunities to act on their incentives to manage earnings. 1 INTRODUCTION We examine whether incentives for management and opportunities from monitoring influence managers' judgments in resolving financial reporting issues. Auditor-client negotiations typically arise in the context of both auditor and management incentives (Gibbins et al. 2001; Gibbins et al. 2007), yet prior accounting research has largely focused on the negotiation judgments from the auditor's perspective and less so from the client's perspective 1 Examining the manager's perspective is important since they prepare the financial statements and thus essentially make the first offer in audit negotiation. …
PROLYL ENDOPEPTIDASE INHIBITORS : A NEW CLASS OF MEMORY ENHANCING DRUGS

could be implicated in amyloidogenesis (5). Although the activity of PEP is very low as the cleaving enzyme of amyloid precursor protein, this finding has attracted great interest in the plausible inhibitory activity of PEP inhibitors in brain amyloidosis. Recently, protective activity of SP against the neurodegenerative effect of β-amyloid was demonstrated in the adult rat (6). Since SP is known to be a substrate for PEP, it is expected that an inhibitor of this enzyme might possess neuroprotective activity by inhibiting SP degradation, thus elevating its cerebral content. In 1987, Yoshimoto et al . reported that an in vitr oPEP inhibitor had in viv oantiamnesic properties in the passive avoidance learning test using scopolamine-induced amnesia in the rat (7). Likewise, novel molecules likely to interact with this enzyme are intensively awaited. The purpose of this paper is to review the synthetic low-molecular weight PEP inhibitors.
The "Digital Divide": Hispanic college students' views of educational uses of the Internet

Concern has been expressed recently regarding the presence of a digital divide between majority and minority groups. Surveyed were 226 Hispanic college freshmen enrolled at a doctoral intensive institution in the Southwest regarding their attitudes toward educational uses of the Internet and their uses of technology. Statistically significant differences were found between males and females in their attitudes toward and uses of the Internet and computer technology. Differences were also revealed between students whose primary language spoken at home was English and students whose primary language spoken at home was Spanish in their attitudes toward and uses of the Internet and computer technology. Interestingly, no differences were present between first-generation and non-first-generation college students. Implications of our findings and relationships to existing literature are provided.
Assessment of viscoelasticity and hydration effect of herbal moisturizers using bioengineering techniques

Background: A number of moisturizers are available containing natural hydrating, moisturizing, fi rming and occlusive property-imparting agent in the form of herbal extracts, juice and oils. The aim of this study is to assess the hydration and viscoelastic effect of commercially available herbal moisturizers, containing different herbs, on human skin, after a single and 3-week period of application using skin bio mechanical and electrical techniques. Materials and Methods: Twenty selected herbal moisturizers (HM) were coded as HM1-HM20. Forty volunteers, mean age of 40 ± 9 years, were participated in the short- and long-term study. Skin properties in terms of hydration and viscoelastic parameters were measured by multitester and cutometer, respectively. Measurements were done before and after 1, 2, and 3 h (single application) and for the 3-week period of daily application. Results: After single application, significant increase has been observed in both the skin electrical (P < 0.001) and mechanical properties (P < 0.01) as compared to the control, at which no products were applied. After the 3-week period, both effects are maintained and found to be significant at P < 0.001. Short-and long-term study revealed that out of 20 herbal moisturizers, HM8 and HM10 show pronounced increase in skin hydration (90-100%) and HM8, HM10, and HM11 shown marked increase in skin viscoelasticity (90-95%). Conclsuion: The possible reason of maximum effects obtained by these products is multifunctional effects of active ingredients of incorporated herbs. Combined used of both non invasive techniques is useful to substantiate the hydrating and viscoelasticity claim of herbal moisturizer. Short- and long-terms study revealed the best performing herbal moisturizer.
Monodansylpentane as a Blue-Fluorescent Lipid-Droplet Marker for Multi-Color Live-Cell Imaging

Lipid droplets (LDs) are dynamic cellular organelles responsible for the storage of neutral lipids, and are associated with a multitude of metabolic syndromes. Here we report monodansylpentane (MDH) as a high contrast blue-fluorescent marker for LDs. The unique spectral properties make MDH easily combinable with other green and red fluorescent reporters for multicolor fluorescence imaging. MDH staining does not apparently affect LD trafficking, and the dye is extraordinarily photo-stable. Taken together MDH represents a reliable tool to use for the investigation of dynamic LD regulation within living cells using fluorescence microscopy.
Infants' affective responses in the strange situation: effects of prematurity and of quality of attachment.

20 full-term and 20 preterm infants and their mothers were videotaped in the Strange Situation, and the security of their attachment relationships was later determined. Each episode was subsequently divided into consecutive 15-sec intervals, during each of which ratings of facial expressions were performed. From these ratings several summary dimensions of affect were derived (e.g., affective peak and range during all episodes, latency and rise time for onset of distress during separation episodes, and recovery time during reunions). Term and preterm infants did not differ from one another in either the security of attachment or their affective expression and regulation. When groups were combined, patterns of affective expression were significantly different for infants classified as insecure-avoidant, insecure-ambivalent, and securely attached, as well as for group B1 + B2 infants compared to group B3 + B4 babies. The findings indicated that attachment-related affect may reflect an affect continuum that underlies certain mother- and stranger-directed behaviors in the Strange Situation, but that not all aspects of reunion behavior can be predicted by prior separation reactions.
Quantitative Proteomics Analysis of VEGF-Responsive Endothelial Protein S-Nitrosylation Using Stable Isotope Labeling by Amino Acids in Cell Culture (SILAC) and LC-MS/MS

ABSTRACT Adduction of a nitric oxide moiety (NO•) to cysteine(s), termed S-nitrosylation (SNO), is a novel mechanism for NO to regulate protein function directly. However, the endothelial SNO-protein network that is affected by endogenous and exogenous NO is obscure. This study was designed to develop a quantitative proteomics approach using stable isotope labeling by amino acids in cell culture for comparing vascular endothelial growth factor (VEGFA)- and NO donor-responsive endothelial nitroso-proteomes. Primary placental endothelial cells were labeled with “light” (L-12C614N4-Arg and L-12C614N2-Lys) or “heavy” (L-13C615N4-Arg and L-13C615N2-Lys) amino acids. The light cells were treated with an NO donor nitrosoglutathione (GSNO, 1 mM) or VEGFA (10 ng/ml) for 30 min, while the heavy cells received vehicle as control. Equal amounts of cellular proteins from the light (GSNO or VEGFA treated) and heavy cells were mixed for labeling SNO-proteins by the biotin switch technique and then trypsin digested. Biotinylated SNO-peptides were purified for identifying SNO-proteins by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Ratios of light to heavy SNO-peptides were calculated for determining the changes of the VEGFA- and GSNO-responsive endothelial nitroso-proteomes. A total of 387 light/heavy pairs of SNO-peptides were identified, corresponding to 213 SNO-proteins that include 125 common and 27 VEGFA- and 61 GSNO-responsive SNO-proteins. The specific SNO-cysteine(s) in each SNO-protein were simultaneously identified. Pathway analysis revealed that SNO-proteins are involved in various endothelial functions, including proliferation, motility, metabolism, and protein synthesis. We collectively conclude that endogenous NO on VEGFA stimulation and exogenous NO from GSNO affect common and different SNO-protein networks, implicating SNO as a critical mechanism for VEGFA stimulation of angiogenesis.
Are all identity commitments created equally? The importance of motives for commitment for late adolescents’ personal adjustment

On the basis of self-determination theory it is proposed that adolescents’ motives for forming and maintaining identity-relevant commitments can be either autonomous or controlled in nature. This study examined whether motives for identity commitments would add to the prediction of late adolescents’ adjustment beyond the effect of strength of commitment per se. In addition, it was examined how late adolescents’ identity-processing styles would relate to motives for commitment and whether motives for commitment would mediate between identity styles and adjustment. In a sample of 431 late adolescents it was found that autonomous and controlled motives were, respectively, positively and negatively related to adjustment even after taking into account the role of strength of commitment. Each of the three identity styles showed a specific pattern of associations with the motives for commitment, with an information-oriented style relating to the most autonomous and internalized motivational profile. Mediation analyses showed that at least part of the associations between identity styles and adjustment are mediated by motives for commitment. Directions for future research are discussed.
A Reanalysis of Data from the Epidemiologic Catchment Area Study

Background Analysing data from the Epidemiologic Catchment Area (ECA) study, Weissman and colleagues reported that panic disorder was strongly associated with suicide attempt. However, they did not control optimally for comorbid disorders known to increase suicide risk. Method Reanalysing the ECA data, we controlled for comorbid disorders in the aggregate rather than one at a time when we estimated the association between panic disorder and suicide attempt. Results Panic disorder was not associated with an increased risk of suicide attempt. Conclusions Comorbid conditions strongly influence whether people with panic disorder are at especial risk of suicide attempt.
The Residential Preferences of Blacks: Do They Explain Persistent Segregation?

For many decades, it has been argued that the U.S. remains racially segregated because of discrimination in the real-estate market reflecting whites' desire to isolate themselves from African Americans. The only modest declines in black-white segregation since the prohibition of such discrimination in 1968 have provoked a competing hypothesis: residential segregation persists because blacks prefer to live in racially isolated neighborhoods and are reluctant to live in largely white areas. These ideas have not been subject to empirical scrutiny. We use open- and closed-ended survey data from more than 2,000 African Americans in the Multi-City Study of Urban Inequality to examine blacks' preferences and the important related issue of what drives those preferences. We find that African Americans overwhelmingly prefer 50-50 areas, a density far too high for most whites — but their preferences are driven not by solidarity or neutral ethnocentrism but by fears of white hostility. Moreover, almost all blacks are willing to move into largely white areas if there is a visible black presence. White preferences also play a key role, since whites are reluctant to move into neighborhoods with more than a few African Americans.
The Persistence of the Recitation

The classroom observational studies reviewed here are those concerned primarily with describing instructional practices, as opposed to describing the psychological concomitants of different practices. Several of the studies reviewed-favorably comparable to more recent research-apparently had been allowed to fade from the collective memory of the profession before the recent flurry of interest in observational research in the classroom, and we take pleasure in helping to resurrect them. In 1966, the authors assisted Professor Bryce Hudgins in the collection of data, including tape recordings of lessons, in the classes of nine junior high school English teachers (Hudgins and Ahlbrand, 1967; Hoetker, 1967). Because of a special interest of one of the authors in the work of Arno Bellack and his associates on the "rules of the classroom language game" (Bellack, et. al., 1966), forty-five hours of typescripts made from the tape recordings were coded according to selected parts of the category system devised by Bellack (Hoetker, 1967). The teachers in our sample, as may be seen from the comparisons summarized in Table 1, behaved very precisely according to Bellack's "rules," and we raised three questions about this finding. First, why did the teachers behave as they did? Second, what were the effects of this sort of teaching upon the pupils? And,