Miracle-dz/UniFAR-FTUs huggingface dataset:
Multi-class Generative Adversarial Networks with the L2 Loss Function

Generative adversarial networks (GANs) have achieved huge success in unsupervised learning. Most of GANs treat the discriminator as a classiﬁer with the binary sigmoid cross entropy loss function. However, we ﬁnd that the sigmoid cross entropy loss function will sometimes lead to the saturation problem in GANs learning. In this work, we propose to adopt the L2 loss function for the discriminator. The properties of the L2 loss function can improve the stabilization of GANs learning. With the usage of the L2 loss function, we propose the multi-class generative adversarial networks for the purpose of image generation with multiple classes. We evaluate the multi-class GANs on a handwritten Chinese characters dataset with 3740 classes. The experiments demonstrate that the multi-class GANs can generate elegant images on datasets with a large number of classes. Comparison experiments between the L2 loss function and the sigmoid cross entropy loss function are also conducted and the results demonstrate the stabilization of the L2 loss function.
Estrogenic activity assessment of environmental chemicals using in vitro assays: identification of two new estrogenic compounds.

Environmental chemicals with estrogenic activities have been suggested to be associated with deleterious effects in animals and humans. To characterize estrogenic chemicals and their mechanisms of action, we established in vitro and cell culture assays that detect human estrogen receptor [alpha] (hER[alpha])-mediated estrogenicity. First, we assayed chemicals to determine their ability to modulate direct interaction between the hER[alpha] and the steroid receptor coactivator-1 (SRC-1) and in a competition binding assay to displace 17ss-estradiol (E(2)). Second, we tested the chemicals for estrogen-associated transcriptional activity in the yeast estrogen screen and in the estrogen-responsive MCF-7 human breast cancer cell line. The chemicals investigated in this study were o,p'-DDT (racemic mixture and enantiomers), nonylphenol mixture (NPm), and two poorly analyzed compounds in the environment, namely, tris-4-(chlorophenyl)methane (Tris-H) and tris-4-(chlorophenyl)methanol (Tris-OH). In both yeast and MCF-7 cells, we determined estrogenic activity via the estrogen receptor (ER) for o,p'-DDT, NPm, and for the very first time, Tris-H and Tris-OH. However, unlike estrogens, none of these xenobiotics seemed to be able to induce ER/SRC-1 interactions, most likely because the conformation of the activated receptor would not allow direct contacts with this coactivator. However, these compounds were able to inhibit [(3)H]-E(2) binding to hER, which reveals a direct interaction with the receptor. In conclusion, the test compounds are estrogen mimics, but their molecular mechanism of action appears to be different from that of the natural hormone as revealed by the receptor/coactivator interaction analysis. ImagesFigure 1Figure 2Figure 3Figure 4Figure 5Figure 6Figure 7Figure 8
A Reduce and Replace Strategy for Suppressing Vector-Borne Diseases: Insights from a Stochastic, Spatial Model

Two basic strategies have been proposed for using transgenic Aedes aegypti mosquitoes to decrease dengue virus transmission: population reduction and population replacement. Here we model releases of a strain of Ae. aegypti carrying both a gene causing conditional adult female mortality and a gene blocking virus transmission into a wild population to assess whether such releases could reduce the number of competent vectors. We find this “reduce and replace” strategy can decrease the frequency of competent vectors below 50% two years after releases end. Therefore, this combined approach appears preferable to releasing a strain carrying only a female-killing gene, which is likely to merely result in temporary population suppression. However, the fixation of anti-pathogen genes in the population is unlikely. Genetic drift at small population sizes and the spatially heterogeneous nature of the population recovery after releases end prevent complete replacement of the competent vector population. Furthermore, releasing more individuals can be counter-productive in the face of immigration by wild-type mosquitoes, as greater population reduction amplifies the impact wild-type migrants have on the long-term frequency of the anti-pathogen gene. We expect the results presented here to give pause to expectations for driving an anti-pathogen construct to fixation by relying on releasing individuals carrying this two-gene construct. Nevertheless, in some dengue-endemic environments, a spatially heterogeneous decrease in competent vectors may still facilitate decreasing disease incidence.
Study on Microbial Community Characteristics in the Northern Wetland Reserve Area of the Modern Yellow River Delta

Yellow River Delta has a special status of coastal wetland research in China. The microbial community characteristics such as community structure, activity and size in the wetland were investigated in the modern Yellow River Delta of Shandong Province. The aim was to find the effect of salinity on the microbial community. There was a significant negative linear relationship between soluble salt content and the total number of microbes, overall microbial activity, and diversity of culturally viable microbes. Differences of the soil bacterial community in different depths were monitored using the terminal restriction fragment length polymorphism (T-RFLP) and clone library analyses. In a word, these results indicate that higher salinity and deeper depth resulted in a smaller, more stressed microbial community which was less active and diverse .
Genetics of Cognition: Outline of a Collaborative Twin Study

Abstract Amultidisciplinary collaborative study examining cognition in a large sample of twins is outlined. A common experimental protocol and design is used in The Netherlands, Australia and Japan to measure cognitive ability using traditional IQ measures (i.e., psychometric IQ), processing speed (e.g., reaction time [RT] and inspection time [IT]), and working memory (e.g., spatial span, delayed response [DR] performance). The main aim is to investigate the genetic covariation among these cognitive phenotypes in order to use the correlated biological markers in future linkage and association analyses to detect quantitativetrait loci (QTLs). We outline the study and methodology, and report results from our preliminary analyses that examines the heritability of processing speed and working memory indices, and their phenotypic correlation with IQ. Heritability of Full Scale IQ was 87% in the Netherlands, 83% in Australia, and 71% in Japan. Heritability estimates for processing speed and working memory indices ranged from 33–64%. Associations of IQ with RT and IT (−0.28 to −0.36) replicated previous findings with those of higher cognitive ability showing faster speed of processing. Similarly, significant correlations were indicated between IQ and the spatial span working memory task (storage [0.31], executive processing [0.37]) and the DR working memory task (0.25), with those of higher cognitive ability showing better memory performance. These analyses establish the heritability of the processing speed and working memory measures to be used in our collaborative twin study of cognition, and support the findings that individual differences in processing speed and working memory may underlie individual differences in psychometric IQ.
Simulation of the Recent Multidecadal Increase of Atlantic Hurricane Activity Using an 18-km-Grid Regional Model

In this study, a new modeling framework for simulating Atlantic hurricane activity is introduced. The model is an 18-km-grid nonhydrostatic regional model, run over observed specified SSTs and nudged toward observed time-varying large-scale atmospheric conditions (Atlantic domain wavenumbers 0–2) derived from the National Centers for Environmental Prediction (NCEP) reanalyses. Using this “perfect large-scale model” approach for 27 recent August–October seasons (1980–2006), it is found that the model successfully reproduces the observed multidecadal increase in numbers of Atlantic hurricanes and several other tropical cyclone (TC) indices over this period. The correlation of simulated versus observed hurricane activity by year varies from 0.87 for basinwide hurricane counts to 0.41 for U.S. landfalling hurricanes. For tropical storm count, accumulated cyclone energy, and TC power dissipation indices the correlation is ~0.75, for major hurricanes the correlation is 0.69, and for U.S. landfalling tropical st.
Improving coverage prediction for primary multi-transmitter networks operating in the TV whitespaces

Future wireless networks will be able to exploit unused spectrum whitespaces in the currently underutilized terrestrial TV bands. In order to protect incumbent broadcasting systems from extensive interference from whitespace devices, accurate signal power estimations are needed. Reliable and robust models for predicting the radio propagation in those bands are thus a key enabler of secondary operations. Depending on their level of abstraction and the complexity of the environment, these models can perform quite well, but they require a significant amount of auxiliary information and fine-tuning. Additionally, they usually consider transmitters in one frequency band to have uncorrelated signals, an uncommon scenario in today's digital TV networks where the same geographical area is often served by multiple towers that form a single-frequency network (SFN). Using data from a measurement campaign carried out in a mid-sized Central European city we assess the accuracy of three widely used propagation models in predicting TV signal strengths for configurations of multiple high-power transmitters. We empirically show that the standard deviation of the estimation error is up to 4 dB higher in a multi-transmitter scenarios with correlated signals than in the single-transmitter case. We put the results in contrast to the prediction capabilities of a generic propagation model that estimates pathloss coefficients and individual correction factors from measurements and combines them with information on transmitter locations, power emissions and antenna patterns. Finally, we study the use of spatial statistics based techniques for directly estimating the coverage characteristics without relying on explicit transmitter information. We show that with only a small subset of measurement locations accuracy beyond standard pathloss models can be achieved.
Malonylation is a key reaction in the metabolism of xenobiotic phenolic glucosides in Arabidopsis and tobacco.

Tobacco cells (Nicotiana tabacum L.) accumulate harmful naphthols in the form of malonylated glucosides (Taguchi et al., 2005). Here, we showed that the malonylation of glucosides is a system to metabolize xenobiotics and is common to higher plants. Moreover, some plantlets including Arabidopsis thaliana excreted some of the incorporated naphthols into the culture media as their glucosides. In order to analyze the function of malonylation in the metabolism of these xenobiotics, we identified a malonyltransferase gene (At5g39050) responsible for the malonylation of these compounds in A. thaliana. The recombinant enzyme had malonyltransferase activity toward several phenolic glucosides including naphthol glucosides. A knockout mutant of At5g39050 (pmat1) exposed to naphthols accumulated only a few malonylglucosides in the cell, and released larger amounts of simple glucosides into the culture medium. In contrast, forced expression of At5g39050 in the pmat1 mutant resulted in increased malonylglucoside accumulation and decreased glucoside excretion to the media. The results provided clear evidence of whether the release of glucosides or the storage of malonylglucosides was determined by the At5g39050 expression level. A similar event in naphthol metabolism was observed in the tobacco mutant with a suppressed malonyltransferase gene (NtMaT1). These results suggested that malonylation could be a key reaction to separate the way of xenobiotics disposition, that is, release from cell surface or storage in vacuoles.
Cytoskeleton-associated plectin: in situ localization, in vitro reconstitution, and binding to immobilized intermediate filament proteins

The association and interaction of plectin (Mr 300,000) with intermediate filaments and filament subunit proteins were studied. Immunoelectron microscopy of whole mount cytoskeletons from various cultured cell lines (rat glioma C6, mouse BALB/c 3T3, and Chinese hamster ovary) and quick-frozen, deep-etched replicas of Triton X-100- extracted rat embryo fibroblast cells revealed that plectin was primarily located at junction sites and branching points of intermediate filaments. These results were corroborated by in vitro recombination studies using vimentin and plectin purified from C6 cells. Filaments assembled from mixtures of both proteins were extensively crosslinked by oligomeric plectin structures, as demonstrated by electron microscopy of negatively stained and rotary- shadowed specimens as well as by immunoelectron microscopy; the binding of plectin structures on the surface of filaments and cross-link formation occurred without apparent periodicity. Plectin's cross- linking of reconstituted filaments was also shown by ultracentrifugation experiments. As revealed by the rotary-shadowing technique, filament-bound plectin structures were oligomeric and predominantly consisted of a central globular core region of 30-50 nm with extending filaments or filamentous loops. Solid-phase binding to proteolytically degraded vimentin fragments suggested that plectin interacts with the helical rod domain of vimentin, a highly conserved structural element of all intermediate filament proteins. Accordingly, plectin was found to bind to the glial fibrillar acidic protein, the three neurofilament polypeptides, and skin keratins. These results suggest that plectin is a cross-linker of vimentin filaments and possibly also of other intermediate filament types.
No Hot Spot Non-blocking Skip List

This paper presents a new non-blocking skip list algorithm. The algorithm alleviates contention by localizing synchronization at the least contended part of the structure without altering consistency of the implemented abstraction. The key idea lies in decoupling a modification to the structure into two stages: an eager abstract modification that returns quickly and whose update affects only the bottom of the structure, and a lazy selective adaptation updating potentially the entire structure but executed continuously in the background. On SPECjbb as well as on micro-benchmarks, we compared the performance of our new non-blocking skip list against the performance of the JDK non-blocking skip list. The results indicate that our implementation can me more than twice as fast as the JDK skip list.
Effect of administration of water enriched in O2 by injection or electrolysis on transcutaneous oxygen pressure in anesthetized pigs

Background Oral administration of oxygenated water has been shown to improve blood oxygenation and could be an alternate way for oxygen (O2) supply. In this experiment, tissue oxygenation was compared in anesthetized pigs receiving a placebo or water enriched in O2 by injection or a new electrolytic process. Methods Forty-two pigs randomized in three groups received either mineral water as placebo or water enriched in O2 by injection or the electrolytic process (10 mL/kg in the stomach). Hemodynamic parameters, partial pressure of oxygen in the arterial blood (PaO2), skin blood flow, and tissue oxygenation (transcutaneous oxygen pressure, or TcPO2) were monitored during 90 minutes of general anesthesia. Absorption and tissue distribution of the three waters administered were assessed using dilution of deuterium oxide. Results Mean arterial pressure, heart rate, PaO2, arteriovenous oxygen difference, and water absorption from the gut were not significantly different among the three groups. The deuterium to protium ratio was also similar in the plasma, skin, and muscle at the end of the protocol. Skin blood flow decreased in the three groups. TcPO2 slowly decreased over the last 60 minutes of the experiment in the three groups, but when compared to the control group, the values remained significantly higher in animals that received the water enriched in O2 by electrolysis. Conclusions In this protocol, water enriched in O2 by electrolysis lessened the decline of peripheral tissue oxygenation. This observation is compatible with the claim that the electrolytic process generates water clathrates which trap O2 and facilitate O2 diffusion along pressure gradients. Potential applications of O2-enriched water include an alternate method of oxygen supply.
Smart Composite Sandwich Structures for Future Aerospace Application -Damage Detection and Suppression-: a Review

Sandwich structures with advanced composite facesheets are attracting much attention as a solution to maximize the potential of composite materials. However, the composite sandwich structures are prone to damage, such as impact damage and debonding. Although these damages are difficult to detect using conventional nondestructive inspection method, they cause significant reduction in the mechanical properties. Hence, several researchers have attempted to detect and suppress the damages using smart sensors and actuators. In this paper recent developments on smart technologies to improve reliability of the composite sandwich structures are reviewed. First, the state-of-the-art sandwich technology in aerospace application is presented. Next, typical damages in composite sandwich structures are described, which is essential to effectively apply the smart technologies to sandwich structures. Then, smart technologies which have been applied to sandwich structures are briefly shown with focusing specific properties of sandwich structures. It includes damage detection using dynamic response, wave propagation and optical fiber sensors. Finally, a smart honeycomb sandwich concept is also presented.
The type II poly(A)-binding protein PABP-2 genetically interacts with the let-7 miRNA and elicits heterochronic phenotypes in Caenorhabditis elegans

The type II poly(A)-binding protein PABP2/PABPN1 functions in general mRNA metabolism by promoting poly(A) tail formation in mammals and flies. It also participates in poly(A) tail shortening of specific mRNAs in flies, and snoRNA biogenesis in yeast. We have identified Caenorhabditis elegans pabp-2 as a genetic interaction partner of the let-7 miRNA, a widely conserved regulator of animal stem cell fates. Depletion of PABP-2 by RNAi suppresses loss of let-7 activity, and, in let-7 wild-type animals, leads to precocious differentiation of seam cells. This is not due to an effect on let-7 biogenesis and activity, which remain unaltered. Rather, PABP-2 levels are developmentally regulated in a let-7-dependent manner. Moreover, using RNAi PABP-2 can be depleted by >80% without significantly impairing larval viability, mRNA levels or global translation. Thus, it unexpectedly appears that the bulk of PABP-2 is dispensable for general mRNA metabolism in the larva and may instead have more restricted, developmental functions. This observation may be relevant to our understanding of why the phenotypes associated with human PABP2 mutation in oculopharyngeal muscular dystrophy (OPMD) seem to selectively affect only muscle cells.
Untwisting two-way transducers in elementary time

Functional transductions realized by two-way transducers (equivalently, by streaming transducers and by MSO transductions) are the natural and standard notion of “regular” mappings from words to words. It was shown recently (LICS'13) that it is decidable if such a transduction can be implemented by some one-way transducer, but the given algorithm has non-elementary complexity. We provide an algorithm of different flavor solving the above question, that has double exponential space complexity. We further apply our technique to decide whether the transduction realized by a two-way transducer can be implemented by a sweeping transducer, with either known or unknown number of passes.
Quantifying mechanical force in axonal growth and guidance

Mechanical force plays a fundamental role in neuronal development, physiology, and regeneration. In particular, research has shown that force is involved in growth cone-mediated axonal growth and guidance as well as stretch-induced elongation when an organism increases in size after forming initial synaptic connections. However, much of the details about the exact role of force in these fundamental processes remain unknown. In this review, we highlight: (1) standing questions concerning the role of mechanical force in axonal growth and guidance; and (2) different experimental techniques used to quantify forces in axons and growth cones. We believe that satisfying answers to these questions will require quantitative information about the relationship between elongation, forces, cytoskeletal dynamics, axonal transport, signaling, substrate adhesion, and stiffness contributing to directional growth advance. Furthermore, we address why a wide range of force values have been reported in the literature, and what these values mean in the context of neuronal mechanics. We hope that this review will provide a guide for those interested in studying the role of force in development and regeneration of neuronal networks.
Photochemical instability of the ancient Martian atmosphere

[1] We develop a 1-D steady state photochemical model of the modern Martian atmosphere and apply it to possible Martian atmospheres present and past. A unique feature of our model is that the major current sink of oxygen is dry deposition (surface reactions) of highly reactive, oxidized molecules (chiefly H2O2), rather than oxygen escape to space. Another difference is that we allow hydrogen to escape to space at the diffusion limit, which gives H escape fluxes ∼70% higher than in other models. What results is a model with one free parameter: a dry deposition velocity to describe the surface sink of reactive molecules. An effective global average deposition velocity of 0.02 cm s−1 for H2O2 and O3 gives a good match to the observed abundances of O2, CO, and H2, the three abundant photochemical trace gases. We then apply our model to Martian atmospheres with different amounts of CO2, H2O, and solar forcing. We find that thick, cold, dry CO2 atmospheres are photochemically unstable with respect to conversion to CO. This may be pertinent to ancient Mars when the Sun was faint and O escape rates were likely high, for which the tipping point is computed to be ∼10 mbar of CO2. The possible photochemical instability of cold thick CO2 atmospheres, and the high likelihood that CO was abundant even if CO2 were stable, has broad implications for early Mars.
Online Curriculum Planning Behavior of Teachers

Curriculum planning is perhaps one of the most important tasks teachers must perform before instruction. While this task is facilitated by a wealth of existing online tools and resources, teachers are increasingly over-whelmed with finding, adapting and aligning relevant resources that support them in their planning. Consequently, ripe research opportunities exist to study and understand online planning behavior in order to more generally characterize planning behavior. In this paper, we introduce a web-based curriculum planning tool and study its use by middle and high school Earth science teachers. We examine the web analytics component of the tool and apply clustering algorithms to model and discover patterns of the use within the system. Our initial results provide insights into the use of the tool over time and indicate teachers are engaging in behavior that show affinity for the use of interactive digital resources as well as social sharing behaviors. These results show tremendous promise in developing teacher-centric analysis techniques to improve planning technologies and techniques to study online curriculum planning patterns.