Miracle-dz/UniFAR-FTUs huggingface dataset:
A Comparison of Sexual Side Effects of Antidepressants With and Without Naltrexone

ABSTRACT Objective: The aim of the study was to compare the rate of sexual side effects of the selective serotonin reuptake inhibitor paroxetine versus the tricyclic antidepressant desipramine and to examine the effect of co-prescription of naltrexone on sexual side effects among participants in a randomized clinical trial. Methods: This was a secondary analysis (N = 88) of veterans who participated in a 12-week trial. All veterans were randomized into one of four treatment groups: (a) desipramine/naltrexone, (b) desipramine/placebo, (c) paroxetine/naltrexone, and (d) paroxetine/placebo. The main outcome measure was the frequency of sexual side effects consisting of “decreased sex drive” and/or “impotence” reported by veterans at each weekly visit. Results: Approximately 61% of the veterans reported sexual side effects at least once during the trial, and 26.4% reported sexual side effects throughout the study. There were no significant differences in the frequency of sexual side effects among the four treatment groups. The results were similar when the comparison was made between the two antidepressant groups. There were no significant differences in the reporting of sexual side effects between those receiving desipramine and paroxetine. Also, the comparison between naltrexone and placebo did not alter the results. Conclusions: This is the first study to compare frequency of sexual side effect reporting between paroxetine and desipramine. We found no statistically significant differences in sexual side effect reporting between the two antidepressants. Also, the addition of naltrexone did not show any beneficial effect on the sexual side effect profile.
Cortical silent period duration and its implications for surround inhibition of a hand muscle

Surround inhibition is a neural mechanism that assists in the focusing of excitatory drive to muscles responsible for a given movement (agonist muscles) by suppressing unwanted activity in muscles not relevant to the movement (surround muscles). The purpose of the study was to determine the contribution of γ‐aminobutyric acidB receptor‐mediated intracortical inhibition, as assessed by the cortical silent period (CSP), to the generation of surround inhibition in the motor system. Eight healthy adults (five women and three men, 29.8 ± 9 years) performed isometric contractions with the abductor digiti minimi (ADM) muscle in separate conditions with and without an index finger flexion movement. The ADM motor evoked potential amplitude and CSP duration elicited by transcranial magnetic stimulation were compared between a control condition in which the ADM was activated independently and during conditions involving three phases (pre‐motor, phasic, and tonic) of the index finger flexion movement. The motor evoked potential amplitude of the ADM was greater during the control condition compared with the phasic condition. Thus, the presence of surround inhibition was confirmed in the present study. Most critically, the CSP duration of the ADM decreased during the phasic stage of finger flexion compared with the control condition, which indicated a reduction of this type of intracortical inhibition during the phasic condition. These findings indicate that γ‐aminobutyric acidB receptor‐mediated intracortical inhibition, as measured by the duration of the CSP, does not contribute to the generation of surround inhibition in hand muscles.
Unemployment Persistence: Is There Evidence for Stigma Effects?

We present evidence for a highly significant interaction between state dependence in individual unemployment risk and the business cycle. The disadvantage from having been unemployed in the previous period is smaller in times of relatively high unemployment and larger in times of low unemployment. This is consistent with the existence of stigma effects in the sense that unemployed individuals face difficulties finding a new job because employers interpret unemployment as a negative signal and do so especially when it is easier to find jobs, i.e. when unemployment is low.
Transcatheter arterial embolization for gastroduodenal ulcers bleeding

1 Republic Vilnius University Hospital, 29 Siltnamiu Str. , LT-01430 Vilnius, Lithuania 2 Faculty of Medicine, Vilnius University, 21 M. K. Ciurlionio Str. , LT-03101 Vilnius, Lithuania El. paštas: edgaras.smolskas@gmail.com 1 Respublikinė Vilniaus universitetinė ligoninė, Šiltnamių g. 29, LT-01430 Vilnius, Lietuva 2 Vilniaus universiteto Medicinos fakultetas, M. K. Čiurlionio g. 21, LT-03101 Vilnius, Lietuva E-mail: edgaras.smolskas@gmail.com
Affitoxin—A Novel Recombinant, HER2-specific, Anticancer Agent for Targeted Therapy of HER2-positive Tumors

Expression of the human epidermal growth factor receptor 2 (HER2) is amplified in 25% to 30% of breast cancers and has been associated with an unfavorable prognosis. Here we report the construction, purification, and characterization of Affitoxin—a novel class of HER2-specific cytotoxic molecules combining HER2-specific Affibody molecule as a targeting moiety and PE38KDEL, which is a truncated version of Pseudomonas exotoxin A, as a cell killing agent. It is highly soluble and does not require additional refolding, oxidation, or reduction steps during its purification. Using surface plasmon resonance technology and competitive binding assays, we have shown that Affitoxin binds specifically to HER2 with nanomolar affinity. We have also observed a high correlation between HER2 expression and retention of Affitoxin bound to the cell surface. Affitoxin binding and internalization is followed by Pseudomonas exotoxin A activity domain-mediated ADP-ribosylation of translation elongation factor 2 and, consequently, inhibition of protein synthesis as shown by protein expression analysis of HER2-positive cells treated with Affitoxin. Measured IC50 value for HER2-negative cells MDA-MB468 (65±2.63 pM) was more than 20 times higher than the value for low HER2 level-expressing MCF7 cells (2.56±0.1 pM), and almost 3 orders of magnitude higher for its HER2-overexpressing derivative MCF7/HER2 (62.7±5.9 fM). These studies suggest that Affitoxin is an attractive PE38-based candidate for treatment of HER2-positive tumors.
Validity of Self-Reported Time to Pregnancy

Background: The reliability of retrospective time to pregnancy (TTP) has been established, but its validity has been assessed in only 1 study, which had a short follow-up. Methods: Ninety-nine women enrolled a decade earlier in a prospective TTP study were queried by means of mailed questionnaires about the duration of time they had required to become pregnant. Their responses were compared with their earlier data from daily diaries (gold standard). Results: One-third of women could not recall their earlier TTP either in menstrual cycles or calendar months. Only 17%–19% of women recalled their TTP exactly. Agreement increased to 41%–51%, 65%–72%, and 72%–77% when defined as ±1, ±2, and ±3 months, respectively. Women with longer observed TTPs or previous pregnancies were more likely to under-report their TTP. Conclusions: The findings raise questions about the commonly assumed validity of self-reported TTP. Recalled TTP may introduce error when estimating fecundability or classifying couples’ fecundity status.
Mobile MultiModal dynamic output morphing tourist systems

TeleMorph dynamically generates multimedia presentations using output modalities that are determined by the bandwidth available on a mobile device’s wireless connection. To demonstrate the effectiveness of this research TeleTuras, a tourist information guide for the city of Derry will implement the solution provided by TeleMorph, thus demonstrating its effectiveness. This paper concentrates on the motivation for & issues surrounding intelligent tourist systems.
Prevalence, correlates, disability, and comorbidity of DSM-IV narcissistic personality disorder: results from the wave 2 national epidemiologic survey on alcohol and related conditions.

OBJECTIVES To present nationally representative findings on prevalence, sociodemographic correlates, disability, and comorbidity of narcissistic personality disorder (NPD) among men and women. METHOD Face-to-face interviews with 34,653 adults participating in the Wave 2 National Epidemiologic Survey on Alcohol and Related Conditions conducted between 2004 and 2005 in the United States. RESULTS Prevalence of lifetime NPD was 6.2%, with rates greater for men (7.7%) than for women (4.8%). NPD was significantly more prevalent among black men and women and Hispanic women, younger adults, and separated/divorced/widowed and never married adults. NPD was associated with mental disability among men but not women. High co-occurrence rates of substance use, mood, and anxiety disorders and other personality disorders were observed. With additional comorbidity controlled for, associations with bipolar I disorder, post-traumatic stress disorder, and schizotypal and borderline personality disorders remained significant, but weakened, among men and women. Similar associations were observed between NPD and specific phobia, generalized anxiety disorder, and bipolar II disorder among women and between NPD and alcohol abuse, alcohol dependence, drug dependence, and histrionic and obsessive-compulsive personality disorders among men. Dysthymic disorder was significantly and negatively associated with NPD. CONCLUSIONS NPD is a prevalent personality disorder in the general U.S. population and is associated with considerable disability among men, whose rates exceed those of women. NPD may not be as stable as previously recognized or described in the DSM-IV. The results highlight the need for further research from numerous perspectives to identify the unique and common genetic and environmental factors underlying the disorder-specific associations with NPD observed in this study.
Characterization of IQ Domain Gene Homologs as Common Candidate Genes for Elongated Fruit Shape inCucurbits

The SUN gene is responsible for an elongated fruit shape in tomato and belongs to the IQ domain (IQD) gene family, which is involved in growth and development in plants. In the present study, IQD gene homologs were evaluated for their roles in determining fruit shape in cucurbit crops. A total of 151 IQD homologs and their chromosomal locations in Arabidopsis, tomato, and three cucurbit species, watermelon, melon, and cucumber, were compared based on their genomic information. A phylogenetic dendrogram of these IQD homologs revealed putative orthologous and paralogous relationships among these genes, and showed that previously reported candidate fruit shape IQD genes in watermelon (ClSUN8), melon (CmSUN14), and cucumber (CsSUN2) were clustered under the same node with a similarity coefficient of 0.97. A comparison of the physical locations of the IQD homologs with fruit shape QTLs in genetic maps indicated that ClSUN8, CmSUN14, and CsSUN2 were co-localized with the major QTLs for the fruit shape index (FSI). This co-localization further indicated that minor QTLs for FSI were also associated with the IQD gene family. We used early developmental stages of immature fruits to conduct a morphological assay and characterize ClSUN8 in watermelon. Histological analysis indicated that elongated or round fruit shape is determined at the early stage of ovary formation, at least earlier than -4 days after fertilization (-4 DAF), and fruit elongation is due to increased cell division in the longitudinal direction. Quantitative RT-PCR showed that the highest expression of ClSUN8 occurred at -4 days after fertilization and gradually decreased; however, there was no direct relationship between the gene expression level and fruit shape. RACE-PCR revealed a non-synonymous SNP between the ClSUN8 alleles of elongatedand round-fruited watermelon accessions, suggesting that the SNP might be a causative mutation affecting fruit shape. Additional key words: allelic variation, Cucurbitacea, molecular marker, paraffin section, phylogeny
“Getting the Point” of Literature: Relations Between Processing and Interpretation

Comparisons of literary experts and novices indicate that experts engage in interpretive processes to “get the point” during their reading of literary texts but novices do not. In two studies the reading and interpretive processes of literary novices (undergraduates with no formal training in literature study) were elicited through think-alouds during reading and a post-reading interview task. Twenty undergraduates read one of two short stories in each of two studies (n = 80). Both studies used the same methodology, except that the instructions for Study 2 emphasized the importance of interpretation when reading literary short stories. Results indicate that literary novices noticed cues to interpretive meaning during reading but were more likely to provide literary interpretations (symbolic and thematic) during the interview task as compared with when reading (Study 1 and 2) and when the instructions emphasized interpretation (Study 2 as compared with Study 1). In both studies there were positive relationships between elaborative processing during reading and (1) providing interpretations during reading and thinking aloud and (2) producing prompted interpretations during the post-reading interview task. The present studies provide evidence that literary novices can and do generate literary interpretations, albeit less sophisticated than those experts would likely generate. Further, elaborative processing during reading was positively related to interpretations. Implications for instruction to enhance literary interpretations are discussed.
ADL performance of black Americans and white Americans on the assessment of motor and process skills.

OBJECTIVE The purpose of this study was to examine whether the Assessment of Motor and Process Skills (AMPS), an assessment of personal and domestic activities of daily living (ADL) performance, can be used as a valid, nonbiased tool when assessing black Americans. METHOD The participants were 466 blacks and 466 whites drawn from the entire sample of blacks and whites contained in the AMPS database who met the following criteria: (a) were 16 years of age and older; (b) had a notable history of a neurological, musculoskeletal, medical, developmental, cognitive, or psychiatric disorders or were healthy older persons; and (c) resided in North America. The participants were matched according to functional level, gender, diagnosis, and age. Examination for bias included between-group comparison of (a) item difficulty and task challenge hierarchies of the AMPS, (b) goodness-of-fit of the participants to the many-faceted Rasch (MFR) model, and (c) mean ADL motor and ADL process abilities. RESULTS Both the item difficulty and the task challenge hierarchies remained stable between the two groups. On the ADL Motor scale, 95.3% of the black participants and 92.4% of the white participants demonstrated acceptable goodness-of-fit (MS < or = 1.4, z < 2) to the MFR model. On the ADL Process scale, 91.2% of the black participants and 90.1% of the white participants demonstrated acceptable goodness-of-fit. A significant difference, t(2, 930) = 3.56, p < . 01, between the two groups was found in mean ADL process ability, but no significant difference, t(2, 930) = . 69, p = . 49) was found in mean ADL motor ability. CONCLUSION The results of this study support the validity of the AMPS when applied to black Americans.
ISOLATION AND PARTIAL CHARACTERIZATION OF A LECTIN FROM BAUHINIA PENTANDRA ( BONG ) VOG

Bauhinia pentandra (Bong) Vog. ex. Steua seeds were investigated with respect to phenologic aspects (size, mass, hilum and length) and with respect to their chemical composition. The total nitrogen content of the seed flour was determined, and the flour was extracted in different pH values. A lectin was isolated from the seeds by Sepharose-4B affinity chromatography. The homogeneity of the lectin was demonstrated by SDS-PAGE in the presence of β-mercaptoethanol. Only one protein band with an apparent molecular mass of 30 kDa was found. The B. pentandra lectin showed a carbohydrate specificity for D-galactose, a requirement for divalent metal cations (Ca and Mn) for full activity and amino acid composition with a high content of aspartic acid, glutamic acid and alanine and low levels of methionine, cysteine and tryptophan. The lectin agglutinated rabbit and human A group erythrocytes and was relatively stable to heat treatment, retaining half of its original activity after 60 min at 70 C. ADDITIONAL INDEX TERMS – Bauhinia, Leguminosae, phytohemagglutinin, seed protein, Dgalactose. ISOLAMENTO E CARACTERIZAÇÃO PARCIAL DE UMA LECTINA DE BAUHINIA PENTANDRA (BONG) VOG. EX. STEUA. RESUMO – Sementes de Bauhinia pentandra (Bong) Vog. ex. Steua. foram estudadas quanto aos aspectos fenológicos (tamanho, massa e comprimento do hilo) e quanto a sua composição química. A farinha de sementes teve o teor de nitrogênio total determinado e foi submetida à extração de proteínas em diferentes valores de pH. Uma lectina foi isolada de sementes por cromatografia de afinidade em coluna de Sepharose-4B. A homogeneidade da lectina foi demonstrada por eletroforese em gel de poliacrilamida na presença de SDS e β-mercaptoetanol. A lectina mostra apenas uma banda protéica de massa molecular aparente de 30 kDa. A lectina de B. pentandra mostra especificidade por D-galactose, Received: 9/7/2001 Accepted: 17/9/2001 1. Eng. Agrônomo, M.Sc., Grupo de Biofísica Molecular e Espectroscopia / USP, IFSC, São Carlos, SP, 13560-970, e-mail: alcoelho@if.sc. usp.br. Corresponding author. 2. Professor Adjunto, Dr., Depto. de Bioquímica e Biologia Molecular/UFC. 3. Professor Titular, Dr., Depto. de Bioquímica e Biologia Molecular/UFC. Isolation and partial characterization of a lectin . R. Bras. Fisiol. Veg. 13(3):262-269, 2001 263 requer a presença de cátions divalentes (Ca e Mn) para exercer sua atividade e tem uma composição de aminoácido caracterizada pelo alto teor de ácido aspártico, ácido glutamico, alanina e pelo baixo teor de metionina, cisteina e triptofano. A lectina aglutina eritrócitos de coelho e humano do grupo A e foi relativamente resistente ao tratamento térmico, retendo parte de sua atividade original mesmo após 60 min a 70 C. TERMOS ADICIONAIS PARA INDEXAÇÃO – Bauhinia, Leguminosae, fitohemaglutinina, proteína de semente, D-galactose
Commentary on: Lymphomas Associated With Breast Implants: A Review of the Literature.

“If language is not correct, then what is said is not what is meant; if what is said is not what is meant, then what must be done remains undone; … if justice goes astray, then people will stand about in helpless confusion. Hence there must be no arbitrariness in what is said. This matters above everything. ”1Confucius (551–479 BC) Epidemiological studies and previous meta-analyses have shown that breast implant–associated anaplastic large cell lymphoma (BI-ALCL) is a distinct type of T-cell lymphoma involving the capsule or effusion surrounding a breast implant. A United States Food and Drug Administration safety communication in 2011 prompted the American Society of Plastic Surgeons (ASPS) to initiate a patient registry, include BI-ALCL language in patient consent forms warning of this potential malignancy, as well as pressured implant manufacturers to include the same in package inserts. Despite being first described 18 years ago, little progress has been made to understand the etiology or molecular pathogenesis of this lymphoma. In addition, BI-ALCL remains unfamiliar or misunderstood by many oncologists, surgeons, radiologists, pathologists, and patients. In many ways, the authors present a timely and much needed literature review on previous case reports of lymphoma and breast implants.2 The manuscript supports several pertinent findings, including that the presentation of ALCL is a spectrum with occasional disease-related death, that the presence of mass portends a worse prognosis, that cases are not isolated to a particular type of implant, and that improved global awareness is needed. The authors are to be commended for trying to make further sense of a very rare disease that has been sporadically reported over the last two decades. More disease-focused manuscripts are needed on BI-ALCL as diagnosis and treatment of these patients is commonly delayed months and, in some cases, years. However, with so …
Reducing Heterosexism in African American Christian Students: Effects of Multicultural Education Courses

ABSTRACT Sexual-minority college students continue to experience heterosexism in the form of heterosexist and biased language from peers. Religion has been identified as a predictor of sexual prejudice among college students. Yet there is limited research on the intersection of race, religion, and heterosexism, and on interventions designed to address this prejudice. This study examined the effectiveness of multicultural education courses at a large public university on reducing heterosexism in Christian students. Analysis of pre- and post- data using repeated measures ANCOVA indicated African American Christian students had significantly higher heterosexism scores than White Christian students, and African American Christian students had a significant decrease in heterosexism as compared to White Christian students after taking a service learning course. These results have implications for future research and education on prejudice reduction.
Where does HIV hide? A focus on the central nervous system

Purpose of reviewTo review the literature on infection and evolution of HIV within the brain in the context for understanding the nature of the brain reservoir and its consequences. Recent findingsHIV-1 in the brain can evolve in separate compartments within macrophage/microglia and astrocytes. The virus adapts to the brain environment to infect these cells and brain-specific mutations can be found in nearly all genes of the virus. The virus evolves to become more neurovirulent. SummaryThe brain is an ideal reservoir for the HIV. The brain is a relatively immune privileged site and the blood–brain barrier prevents easy access to antiretroviral drugs. Further, the virus infects resident macrophages and astrocytes which are long-lived cells and causes minimal cytopathology in these cells. Hence as we move towards developing strategies for eradication of the virus from the peripheral reservoirs, it is critical that we pay close attention to the virus in the brain and develop strategies for maintaining it in a latent state failure of which could result in dire consequences.
Quenching and Cold-Work Residual Stresses in Aluminum Hand Forgings: Contour Method Measurement and FEM Prediction

The cold-compression stress relief process used to reduce the quench-induced stresses in high-strength aerospace aluminum alloy forgings does not fully relieve the stresses. This study measured and predicted the residual stress in 7050-T74 (solution heat treated, quenched, and artificially overaged) and 7050-T7452 (cold compressed prior to aging) hand forgings. The manu- facturing process was simulated by finite element analysis. First, a thermal analysis simulated the quench using appropriate thermal boundary conditions and temperature dependent material properties. Second, a structural analysis used the thermal history and a temperature and strain-rate dependent constitutive model to predict the stresses after quenching. Third, the structural analysis was continued to simulate the multiple cold compressions of the stress relief process. Experimentally, the residual stresses in the forgings were mapped using the contour method, which involved cutting the forgings using wire EDM and then measuring the contour of the cut surface using a CMM. Multiple cuts were used to map different stress components. The results show a spatially periodic variation of stresses that results from the periodic nature of the cold work stress relief process. The results compare favorably with the finite element prediction of the stresses.