Miracle-dz/UniFAR-FTUs huggingface dataset:
A Theoretical Study of 8-Chloro-9-Hydroxy-Aflatoxin B1, the Conversion Product of Aflatoxin B1 by Neutral Electrolyzed Water

Theoretical studies of 8-chloro-9-hydroxy-aflatoxin B1 (2) were carried out by Density Functional Theory (DFT). This molecule is the reaction product of the treatment of aflatoxin B1 (1) with hypochlorous acid, from neutral electrolyzed water. Determination of the structural, electronic and spectroscopic properties of the reaction product allowed its theoretical characterization. In order to elucidate the formation process of 2, two reaction pathways were evaluated—the first one considering only ionic species (Cl+ and OH−) and the second one taking into account the entire hypochlorous acid molecule (HOCl). Both pathways were studied theoretically in gas and solution phases. In the first suggested pathway, the reaction involves the addition of chlorenium ion to 1 forming a non-classic carbocation assisted by anchimeric effect of the nearest aromatic system, and then a nucleophilic attack to the intermediate by the hydroxide ion. In the second studied pathway, as a first step, the attack of the double bond from the furanic moiety of 1 to the hypochlorous acid is considered, accomplishing the same non-classical carbocation, and again in the second step, a nucleophilic attack by the hydroxide ion. In order to validate both reaction pathways, the atomic charges, the highest occupied molecular orbital and the lowest unoccupied molecular orbital were obtained for both substrate and product. The corresponding data imply that the C9 atom is the more suitable site of the substrate to interact with the hydroxide ion. It was demonstrated by theoretical calculations that a vicinal and anti chlorohydrin is produced in the terminal furan ring. Data of the studied compound indicate an important reduction in the cytotoxic and genotoxic potential of the target molecule, as demonstrated previously by our research group using different in vitro assays.
Global asymptotic and exponential stability of a dynamic neural system with asymmetric connection weights

Recently, a dynamic neural system was presented and analyzed due to its good performance in optimization computation and low complexity for implementation. The global asymptotic stability of such a dynamic neural system with symmetric connection weights was well studied. In this note, based on a new Lyapunov function, we investigate the global asymptotic stability of the dynamic neural system with asymmetric connection weights. Since the dynamic neural system with asymmetric weights is more general than that with symmetric ones, the new results are significant in both theory and applications. Specially, the new result can cover the asymptotic stability results of linear systems as special cases.
Forest ecosystems of the Šumava Mts. and their management

The introductory presentation summarizes natural conditions of the area of interest, state of local forest ecosystems and consequent management rules in this National Park and Protected Landscape Area. It describes area delimitation, natural conditions (geology, geomorphology, hydrology and climat, soils, vegetation, forest stands, their dynamics, healthy status). All these syntheses are a basis for forest management and forestry in this region, respecting forest state and forestry aims, as well as the nature protection targets.
Lobar Hemorrhage in the Elderly: The Undiminishing Importance of Hypertension

Background and Purpose We sought to determine whether hypertension is less common in primary lobar hemorrhage than intracerebral hemorrhage in other locations and whether the frequency of hypertension in lobar hemorrhage diminishes with advancing age. Methods We identified all cases of intracerebral hemorrhage in Greater Cincinnati during 1988 by review of hospital and autopsy records as well as computed tomographic and magnetic resonance scans. Results During 1988, 66 primary lobar hemorrhages occurred, constituting 46% of all intracerebral hemorrhages in those under 75 years of age and 34% in those age 75 and older. A history of hypertension was present in 67% of patients with lobar, 73% of those with deep, 73% of those with cerebellar, and 78% of those with pontine hemorrhages. Left ventricular hypertrophy was present in 21% of patients with lobar, 27% of those with deep, and 47% of those with pontine/cerebellar hemorrhages. The frequency of hypertension in patients with lobar hemorrhage did not decrease with advancing age. Conclusions The proportion of all intracerebral hemorrhages that are lobar does not increase with advancing age. Hypertension is nearly as common in primary lobar hemorrhage as in deep, cerebellar, and pontine hemorrhages, and its importance as an associated condition for lobar hemorrhage does not diminish with advancing age.
Learning Bregman Distance Functions and Its Application for Semi-Supervised Clustering

Learning distance functions with side information plays a key role in many machine learning and data mining applications. Conventional approaches often assume a Mahalanobis distance function. These approaches are limited in two aspects: (i) they are computationally expensive (even infeasible) for high dimensional data because the size of the metric is in the square of dimensionality; (ii) they assume a fixed metric for the entire input space and therefore are unable to handle heterogeneous data. In this paper, we propose a novel scheme that learns nonlinear Bregman distance functions from side information using a non-parametric approach that is similar to support vector machines. The proposed scheme avoids the assumption of fixed metric by implicitly deriving a local distance from the Hessian matrix of a convex function that is used to generate the Bregman distance function. We also present an efficient learning algorithm for the proposed scheme for distance function learning. The extensive experiments with semi-supervised clustering show the proposed technique (i) outperforms the state-of-the-art approaches for distance function learning, and (ii) is computationally efficient for high dimensional data.
Factors Characterizing Staphylococcus epidermidis Invasiveness Determined by Comparative Genomics

ABSTRACT Virulence mechanisms of the leading nosocomial pathogen Staphylococcus epidermidis are poorly understood. We used microarray-based genome-wide comparison of clinical and commensal S. epidermidis strains to identify putative virulence determinants. Our study revealed high genetic variability of the S. epidermidis genome, new markers for invasiveness of S. epidermidis, and potential targets for drug development against S. epidermidis infections.
NUTRIENT CONCENTRATION AND PH IN THE CISADANE ESTUARINE AND COASTAL WATERS

The study on the fluctuation of dissolved nutrient concentrations and acidity (pH) in the Cisadane Estuary was carried out in May 2004 October 2004 and July 2005. Inorganic phosphate, nitrate and silicate of the surface water were analyzed, using Spectrophotometer and pH was measured with a pH meter. Generally the nutrient concentrations in the estuary were higher compared to those in the coastal and offshore areas. The concentrations were gradually becoming lower and lower toward the open sea. Their fluctuation depended not only on the environmental condition but also on the water volurrie from the land and the mangrove forest in that area.
Energy-Efficient WDM Network Planning with Dedicated Protection Resources in Sleep Mode

Energy-efficient optical networks are gaining momentum as environmental-friendly solutions with reduced operational costs. Energy-efficiency can be achieved by using devices in sleep mode, i.e., a low-power, inactive state in which devices can be suddenly waken-up upon occurrence of triggering events. This paper advocates a sleep mode option for the optical devices (e.g., amplifiers, optical switches) installed for protection purposes only. These devices can be put in sleep mode to reduce the network power consumption, but they can be promptly waken up (if necessary) upon a failure occurrence. This principle is proposed and applied in Wavelength Division Multiplexing (WDM) networks with dedicated-path protection to ensure survivability against single-link failures. The main contribution of the paper is the definition of the energy-efficient network planning problem for resilient WDM networks where optical devices can be configured in sleep mode. Optimal results of the integer linear programming (ILP) problem show savings of up to 25% in the overall power consumption.
A Study of Visual Outcome in Lens Induced Glaucoma

Background: Lens induced glaucomas are a common occurrence in rural areas of India. Objective: The purpose of this study was to determine the pattern and visual outcome in LIG cases Methods: This cross sectional study was based on the patients with LIG, who attended the Ophthalmic OPD, Government general hospital, Kakinada. All the patients underwent a complete ophthalmic examination, which included both anterior and posterior segment evaluation Results: A total of 50 patients with a diagnosis of LIG were analyzed. Out of these 31(62%) patients had phacomorphic and 19(38%) had phacolytic glaucoma respectively. All the patients underwent surgery or a combined surgery. Postoperative BCVA upto 6/12 was achieved in 40(80%) and upto 6/60 in 45(90%) patients. Only 5 patients showed poor visual outcome. However, all the patients maintained postoperative IOP of < 20mm Hg without any additional antiglaucoma therapy. Conclusion: Early diagnosis and treatment of mature cataract is very important since delayed treatment of lens-induced glaucoma may result in poor visual outcome.
A nuclear hormone receptor corepressor mediates transcriptional silencing by receptors with distinct repression domains

Ligand-independent transcriptional repression is an important function of nuclear hormone receptors. An interaction screen with the repression domain of the orphan receptor RevErb identified N-CoR, the corepressor for thyroid hormone receptor (TR) and retinoic acid receptor (RAR). N-CoR is likely to be a bona fide transcriptional corepressor for RevErb because (i) RevErb interacts with endogenous N-CoR, (ii) ectopic N-CoR potentiates RevErb-mediated repression, and (iii) transcriptional repression by RevErb correlates with its ability to bind N-CoR. Remarkably, a region homologous to the CoR box which is necessary for TR and RAR to interact with N-CoR is not required for RevErb. Rather, two short regions of RevErb separated by approximately 200 amino acids are required for interaction with N-CoR. The primary amino acid sequence of the N-terminal region of RevErb essential for N-CoR interaction is not homologous to that of TR or RAR, whereas similarities exist among the C-terminal domains of the receptors. N-CoR contains two adjacent but distinct interaction domains, one of which binds tightly to both RevErb and TR whereas the other binds more weakly and differentially interacts with the nuclear receptors. These results indicate that multiple nuclear receptors, utilizing different primary amino acid sequences, repress transcription by interacting with N-CoR.
Heart Rate and Heart Rate Variability Changes in the Intracarotid Sodium Amobarbital Test

Summary: Purpose: Changes in heart rate and heart rate variability have been found in prior studies performed during the intracarotid sodium amobarbital (ISA) test. However, these results are not entirely consistent with current models of differential cerebral involvement in the modulation of the heart. This study was designed to re‐investigate this topic with a larger N than has heretofore been used.
Unsung heroes

Since the introduction of the three year degree programme in 2003, social work education has undergone a number of significant changes. The time students spend on placement has been increased to two hundred days, and the range of placement opportunities and the way in which these placements have been configured has significantly diversified. A consistent feature over the years, however, has been the presence of a Practice Educator (PE) who has guided, assessed and taught the student whilst on placement. Unsurprisingly, the role of the PE and the pivotal relationship they have with the student has been explored in the past and features in social work literature.This paper, however, concentrates on a range of other relationships which are of significance in providing support to students on placement. In particular it draws on research to discuss the role of the university contact tutor, the place of the wider team in which the student is sited, and the support offered by family, friends and others.Placements and the work undertaken by PE’s will continue to be integral to the delivery of social work education. It is, however, essential to recognise and value the often over looked role of others in providing support to students on placement.
Computerized spatial delayed recognition span task: a specific tool to assess visuospatial working memory

A new tablet device version (IOS platform) of the Spatial Delayed Recognition Span Task (SDRST) was developed with the aim of investigating visuospatial Working Memory (WM) abilities based on touchscreen technology. This new WM testing application will be available to download for free in Apple Store app (“SDRST app”). In order to verify the feasibility of this computer-based task, we conducted three experiments with different manipulations and groups of participants. We were interested in investigating if (1) the SDRST is sensitive enough to tap into cognitive differences brought by aging and dementia; (2) different experimental manipulations work successfully; (3) cortical brain activations seen in other WM tasks are also demonstrated here; and (4) non-human primates are able to answer the task. Performance (scores and response time) was better for young than older adults and higher for the latter when compared to Alzheimer’s disease (AD) patients. All groups performed better with facial stimuli than with images of scenes and with emotional than with neutral stimuli. Electrophysiology data showed activation on prefrontal and frontal areas of scalp, theta band activity on the midline area, and gamma activity in left temporal area. There are all scalp regions known to be related to attention and WM. Besides those data, our sample of adult captive capuchin monkeys (Sapajus libidinosus) answered the task above chance level. Taken together, these results corroborate the reliability of this new computer-based SDRST as a measure of visuospatial WM in clinical and non-clinical populations as well as in non-human primates. Its tablet app allows the task to be administered in a wide range of settings, including hospitals, homes, schools, laboratories, universities, and research institutions.
Prediction of outcome after ankle fracture.

STUDY DESIGN Prospective inception cohort study of 62 consecutive patients seen in 2 orthopaedic clinics following ankle fracture. OBJECTIVES To investigate 4 putative predictors (age, fracture classification, acute management [surgical or nonsurgical], and ankle dorsiflexion range of motion measured at the time of cast removal) of outcome after ankle fracture and to develop simple predictive models of outcome after ankle fracture. BACKGROUND Ankle fracture is a common condition. However, few studies have investigated factors that predict outcome after ankle fracture. METHODS AND MEASURES Sixty-two consecutive subjects aged 17 or older with ankle fractures were recruited from 2 hospital orthopaedic clinics. Outcome measures recorded at 6 weeks and 6 months after cast removal included 2 functional questionnaires, patients' ratings of global improvement, and a measure of ankle dorsiflexion. The predictive value of 4 variables selected a priori was analyzed using bivariate and stepwise multiple linear regression. RESULTS Ankle dorsiflexion and fracture classification predicted outcome 6 weeks and 6 months after cast removal for all outcome measures used (P < .05, r2 = 0.09-0.47). Fracture management (surgical or nonsurgical) inconsistently predicted outcome at both 6 weeks and 6 months, and age did not predict outcome at either 6 weeks or 6 months after cast removal. The predictive models explain between 19% and 58% of the variance in outcomes 6 weeks after cast removal and 19% to 52% of the variance in outcomes 6 months after cast removal. CONCLUSION Ankle dorsiflexion measured at the time of cast removal and fracture classification are clinically significant predictors of outcome after ankle fracture; however, much unexplained variation in outcomes still exists.
Involvement of the GTP binding protein Rho in constitutive endocytosis in Xenopus laevis oocytes

To study an endocytotic role of the GTP-binding protein RhoA in Xenopus oocytes, we have monitored changes in the surface expression of sodium pumps, the surface area of the oocyte and the uptake of the fluid-phase marker inulin. Xenopus oocytes possess intracellular sodium pumps that are continuously exchanged for surface sodium pumps by constitutive endo- and exocytosis. Injection of Clostridium botulinum C3 exoenzyme, which inactivates Rho by ADP-ribosylation, induced a redistribution of virtually all intracellular sodium pumps to the plasma membrane and increased the surface area of the oocytes. The identical effects were caused by injection of ADP-ribosylated recombinant RhoA into oocytes. The C3 exoenzyme acts by blocking constitutive endocytosis in oocytes, as determined using a mAb to the beta 1 subunit of the mouse sodium pump as a reporter molecule and oocytes expressing heterologous sodium pumps. In contrast, an increase in endocytosis and a decrease in the surface area was induced by injection of recombinant Val14-RhoA protein or Val14-rhoA cRNA. PMA stimulated sodium pump endocytosis, an effect that was blocked by a specific inhibitor of protein kinase C (Go 16) or by ADP-ribosylation of Rho by C3. Similarly, the phorbol ester-induced increase in fluid-phase endocytosis in oocytes was inhibited by Go 16, C3 transferase, or by injection of ADP-ribosylated RhoA. In contrast to C3 transferase, C. botulinum C2 transferase, which ADP-ribosylates actin, had no effect on sodium pump endocytosis or PMA-stimulated fluid- phase endocytosis. The data suggests that RhoA is an essential component of a presumably clathrin-independent endocytic pathway in Xenopus oocytes which can be regulated by protein kinase C.
Growing Spatial Scales of Synchronous River Flooding in Europe

River flooding is a common hazard, causing billions of dollars in annual losses. Flood impacts are shaped by the spatial scale over which different rivers flood simultaneously, but this dimension of flood risk remains largely unknown. Using annual flood data from several thousand European rivers, we demonstrate that the flood synchrony scale—the distance over which multiple rivers flood near synchronously—far exceeds the size of individual drainage basins and varies regionally by more than an order of magnitude. These data also show that flood synchrony scales have grown by about 50% over the period 1960–2010. Detrended flood synchrony values are serially correlated, implying that years with spatially extensive floods tend to follow one another. These findings reveal that flood risks are correlated well beyond the individual drainage basins for which flood hazards are typically assessed and managed.
Phasic norepinephrine: A neural interrupt signal for unexpected events

Extensive animal studies indicate that the neuromodulator norepinephrine plays an important role in specific aspects of vigilance, attention and learning, putatively serving as a neural interrupt or reset function. The activity of norepinephrine-releasing neurons in the locus coeruleus during attentional tasks is modulated not only by the animal's level of engagement and the sensory inputs, but also by temporally rich aspects of internal decision-making processes. Here, we propose that it is unexpected changes in the world within the context of a task that activate the noradrenergic interrupt signal. We quantify this idea in a Bayesian model of a well-studied visual discrimination task, demonstrating that the model captures a rich repertoire of noradrenergic responses at the sub-second temporal resolution.
Contemporary Reviews in Cardiovascular Medicine Controversial Issues in the Management of Pericardial Diseases

The management of pericardial diseases is largely empirical because of the relative lack of randomized trials. The first published guidelines1,2 are a first attempt to organize current knowledge. At present, no specific guidelines have been issued by the American Heart Association and American College of Cardiology. After a literature review including a Medline search with the MeSH terms “pericarditis” and “pericardium,” we identified the following controversial issues related mainly to the management of pericarditis and pericardial effusion: (1) etiological search and hospitalization; (2) role of pericardiocentesis, pericardial biopsy, and pericardioscopy; (3) myopericarditis; (4) use of corticosteroids, nonsteroidal antiinflammatory drugs (NSAIDs), and colchicine; (5) management of refractory cases and long-term outcome; (6) role of pericardiectomy, pericardial window, and other interventional techniques; and (7) management of chronic idiopathic pericardial effusion. At the end of each issue, key points are summarized. Management of most cases is done by general practitioners or different healthcare specialists and does not require specific expertise; nevertheless, incessant and recurrent cases and specific forms (eg, tuberculous pericarditis, neoplastic pericardial disease, autoimmune conditions) require cooperation among specialties (eg, cardiology, infectious diseases, rheumatology, oncology). Specific interventional techniques (eg, pericardioscopy) and pericardiectomy should be performed in referral centers.
Design and Fabrication of S0 Lamb-Wave Thin-Film Lithium Niobate Micromechanical Resonators

Commercial markets desire integrated multifrequency band-select duplexer and diplexer filters with a wide fractional bandwidth and steep roll-off to satisfy the ever-increasing demand for spectrum. In this paper, we discuss the fabrication and design of lithium niobate (LN) thin-film S0 Lamb-wave resonators on a piezoelectric-on-piezoelectric platform. Filters using these resonators have the potential to fulfill all the above requirements. In particular, we demonstrated one-port high-order S0 Lamb-wave resonators with resonant frequencies from ~400 MHz to ~1 GHz on a black rotated y-136 cut LN thin film. The effective electromechanical coupling factor (k2eff ) ranges from 7% to 12%, while the measured quality factor ranges from 600 to 3300. The highest k2eff × Q achieved on this chip is 194, significantly surpassing contour mode resonators manufactured in other technologies.
Quantifying the energy consumption of a pocket computer and a Java virtual machine

In this paper, we examine the energy consumption of a state-of-the-art pocket computer. Using a data acquisition system, we measure the energy consumption of the Itsy Pocket Computer, developed by Compaq Computer Corporation's Palo Alto Research Labs. We begin by showing that the energy usage characteristics of the Itsy differ markedly from that of a notebook computer. Then, since we expect that flexible software environments will become increasingly prevalent on pocket computers, we consider applications running in a Java environment. In particular, we explain some of the Java design tradeoffs applicable to pocket computers, and quantify their energy costs. For the design options we considered and the three workloads we studied, we find a maximum change in energy use of 25%.