Miracle-dz/UniFAR-FTUs huggingface dataset:
Emotion Reactivity, Comfort Expressing Emotions, and Future Suicidal Ideation in Emerging Adults.

OBJECTIVE Emotion reactivity and difficulties in expressing emotions have been implicated in risk for suicidal behavior. This study examined comfort in expressing emotions (positive vs. negative) and depressive symptoms as mediators of the prospective relation between emotion reactivity and suicidal ideation. DESIGN Emerging adults (N = 143; 72% female; 28% White) completed measures of emotion reactivity, comfort expressing emotions, and suicidal ideation at baseline and of depressive symptoms and suicidal ideation 12 months later. RESULTS Emotion reactivity predicted suicidal ideation at follow-up through depressive symptoms. Difficulty expressing love-but not happiness, sadness, and anger-partially mediated the relationship between emotion reactivity and suicidal ideation at follow-up before but not after adjusting for baseline ideation. CONCLUSION The relation between high emotion reactivity and suicidal ideation may be explained by discomfort in the expression of positive emotions and by depressive symptoms. Promotion of comfort in positive emotion expression may reduce vulnerability to suicidal ideation.
Influence of local anesthethics with adrenalina 1:100.000 in basic vital constants during third molar surgery.

OBJECTIVE The present study consists of a double-blind randomized clinical trial of paired samples. The purpose of the present study was thus to examine the effect of four different local anesthetics of the amida group (2% lidocaine with 1:100.000 adrenaline; 3% prilocaine with 0.30 IU felipressine; 2% mepivacaine with 1:100.000 adrenaline; and 4% articaine with 1:100.100 adrenaline) in patients undergoing extraction of lower third molars and verify the changes in systolic, diastolic and mean blood pressures, heart rate (HR) and oxygen saturation (SpO2). STUDY DESIGN The sample comprised 168 extractions of lower third molars performed on 84 patients, divided into three groups, in whom lidocaine was the control anesthetic. The anesthetic solution applied differed from one side of the mouth to the other (control and experimental) in the same patient at different time periods. RESULTS The following significant variations were observed: increase in systolic blood pressure with mepivacaine and articaine; decrease in diastolic blood pressure with lidocaine; increase in heart rate with all the anesthetics, but with no statistical significance in the case of prilocaine. The variations in mean blood pressure and oxygen saturation were not statistically significant. All the hemodynamic changes returned to normal with no need for any further treatment. No complications were observed in any of the 168 procedures performed. CONCLUSION All the anesthetics studied behaved, in relation to lidocaine, within the parameters of hemodynamic safety, although the best performance was that of prilocaine, followed by lidocaine. The measurement of systolic blood pressure, diastolic blood pressure and heart rate are appropriate monitoring methods for patients under the effects of local anesthetic, even healthy ones.
Myconanoparticles: synthesis and their role in phytopathogens management

Nanotechnology can offer green and eco-friendly alternatives for plant disease management. Apart from being eco-friendly, fungi are used as bio-manufacturing units, which will provide an added benefit in being easy to use, as compared to other microbes. The non-pathogenic nature of some fungal species in combination with the simplicity of production and handling will improve the mass production of silver nanoparticles. Recently, a diverse range of fungi have been screened for their ability to create silver nanoparticles. Mycosynthesis of gold, silver, gold–silver alloy, selenium, tellurium, platinum, palladium, silica, titania, zirconia, quantum dots, usnic acid, magnetite, cadmium telluride and uraninite nanoparticles has also been reported by various researchers. Nanotechnological application in plant pathology is still in the early stages. For example, nanofungicides, nanopesticides and nanoherbicides are being used extensively in agriculture practices. Remote activation and monitoring of intelligent nano-delivery systems can assist agricultural growers of the future to minimize fungicides and pesticides use. Nanoparticle-mediated gene transfer would be useful for improvement of crops resistant to pathogens and pest. This review critically assesses the role of fungi in the synthesis of nanoparticles, the mechanism involved in the synthesis, the effect of different factors on the reduction of metal ions in developing low-cost techniques for the synthesis and recovery of nanoparticles. Moreover, the application of nanoparticles in plant disease control, antimicrobial mechanisms, and nanotoxicity on plant ecosystem and soil microbial communities has also been discussed in detail.
A clinical algorithm for the diagnosis of malaria: results of an evaluation in an area of low endemicity

We conducted a study of 1945 children and 2885 adults who presented with fever to a hospital outpatients clinic in an urban area of India order to develop and evaluate a clinical algorithm for the diagnosis of malaria. Only 139 (7%) children and 349 (12%) adults had microscopically confirmed malaria. None of the symptoms or signs elicited from the respondents were good predictors of clinical malaria. Simple scores were derived through combining clinical features which were associated with slide positivity or were judged by clinicians to be important. The best‐performing algorithms were a score of 4 clinical features in children (sensitivity 60.0% and specificity 61.2%) and a score of 5 in adults (sensitivity 54.6% and specificity 57.5%). The clinical features differed and algorithm performances were poorer than in previous studies in highly endemic areas. The conclusion is that malaria diagnosis in areas of low endemicity requires microscopy to be accurate.
ojoplano-mediated basal constriction is essential for optic cup morphogenesis

Although the vertebrate retina is a well-studied paradigm for organogenesis, the morphogenetic mechanisms that carve the architecture of the vertebrate optic cup remain largely unknown. Understanding how the hemispheric shape of an eye is formed requires addressing the fundamental problem of how individual cell behaviour is coordinated to direct epithelial morphogenesis. Here, we analyze the role of ojoplano (opo), an uncharacterized gene whose human ortholog is associated with orofacial clefting syndrome, in the morphogenesis of epithelial tissues. Most notably, when opo is mutated in medaka fish, optic cup folding is impaired. We characterize optic cup morphogenesis in vivo and determine at the cellular level how opo affects this process. opo encodes a developmentally regulated transmembrane protein that localizes to compartments of the secretory pathway and to basal end-feet of the neuroepithelial precursors. We show that Opo regulates the polarized localization of focal adhesion components to the basal cell surface. Furthermore, tissue-specific interference with integrin-adhesive function impairs optic cup folding, resembling the ocular phenotype observed in opo mutants. We propose a model of retinal morphogenesis whereby opo-mediated formation of focal contacts is required to transmit the mechanical tensions that drive the macroscopic folding of the vertebrate optic cup.
Prevalence of pulmonary arteriovenous malformations (PAVMs) and occurrence of neurological symptoms in patients with hereditary haemorrhagic telangiectasia (HHT)

Abstract. Kjeldsen AD, Oxhøj H, Andersen PE, Green A, Vase P (Odense University and Odense University Hospital, Odense; University of Aarhus, Aarhus; and the Department of Otorhinolaryngology, Svendborg, Denmark). Prevalence of pulmonary arteriovenous malformations (PAVMs) and occurrence of neurological symptoms in patients with hereditary haemorrhagic telangiectasia (HHT). J Intern Med 2000; 248: 255–262.
The Selection of Talent

We study how search frictions in the labour market affect firms’ ability to recruit talented workers. In a field experiment in Ethiopia, we show that a small monetary incentive for making a job application enables an employer to attract more talented applicants. The effect is driven by workers with lower income and weaker outside options. It is similar in magnitude to the effect of doubling the wage offer, which we also estimate experimentally. These results are consistent with a model in which talented jobseekers face large application costs and credit constraints. We structurally estimate this model and find that the cost of making an application is large (9-13 percent of the monthly wage on average) and positively correlated with ability. An estimated 30 percent of individuals are unable to pay this cost because of credit constraints. For the average firm in this market, we find that the application incentive has an internal rate of return of 11 percent. However, in a second experiment, we show that local firmmanagers underestimate these positive impacts, explaining why the use of application incentives is limited. Our results show that frictions in the labour market can harm firms and distort the allocation of workers’ talent. ∗We are grateful to Abi Adams, Nava Ashraf, Oriana Bandiera, Vittorio Bassi, Stefano DellaVigna, Marcel Fafchamps, Erica Field, Simon Franklin, DouglasGollin, Clement Imbert, Supreet Kaur, PhilippKircher, Jeremy Magruder, David McKenzie, Guy Michaels, Paul Niehaus, Imran Rasul, Chris Roth, Simon Quinn, Yared Seid, Alemayehu Seyoum Taffesse, Chris Woodruff for helpful comments and to Koen Maskaant and Alemayehu Woldu for outstanding research assistance. We acknowledge funding from the IGC (Project No. 1-VCC-VETHVXXXX-32304). The project would not have been possible without the support of Rose Page, Simon Quinn, CSAE and EDRI. †Ethiopian Development Research Institute. Email: girum.abebe@edri.org. et. ‡University of Oxford. stefano.caria@qeh.ox. ac.uk, Web: stefanocaria.com §University of Oxford. Email: esteban.ortiz-ospina@bsg.ox. ac.uk.
Torpor Characteristics and Energy Requirements of Furless Siberian Hamsters

After approximately 10 wk of exposure to decreasing day lengths, Siberian hamsters (Phodopus sungorus) begin to display spontaneous torpor bouts several times each week. Torpor is associated with reduced daily energy expenditure and lower food consumption and ameliorates the thermoregulatory challenges of winter. We tested the extent to which the energy savings conferred by daily torpor depend on the presence of an insulative pelage. Female hamsters were housed in a winter day length (8L:16D) at 5°C; daily food intake and torpor characteristics were recorded for 5 wk in shaved (furless) or normal hamsters. Torpor‐bout incidence decreased by 62% in furless hamsters, but the duration of individual bouts and the minimum body temperature attained during torpor were unaffected by loss of pelage. Body temperature declined more rapidly during entry into torpor and increased more slowly during arousal from torpor in furless than in control hamsters. Energy savings per torpor bout, assessed by the amount of food consumed on days that included a torpor bout, was substantially greater in normal than in furless hamsters (16.0% vs. 3.3%); this difference likely reflects the increased cost of thermoregulation during torpor, as well as the increased caloric expenditure incurred by furless hamsters during arousal from torpor. An insulative pelage may be a prerequisite for the energetic benefits derived from heterothermy in this species.
Optical fiber sensors for spacecraft applications

The significant advantages of optical fiber sensor systems for spacecraft applications have been established through demonstration projects on both prototype exemplars and flight articles. These include distributed strain sensing using embedded and surface-mounted fiber Bragg grating arrays and ultrahigh sensitivity strain and temperature sensing with fiber cavity etalon sensors. These projects will be discussed with emphasis on sensor performance, reliability, and survivability during composite fabrication, including egress of the fiber lead from the part.
Impact of Diabetes on Long-Term Outcome After Primary Angioplasty

OBJECTIVE Diabetes has been shown to be associated with worse survival and repeat target vessel revascularization (TVR) after primary angioplasty. The aim of the current study was to evaluate the impact of diabetes on long-term outcome in patients undergoing primary angioplasty treated with bare metal stents (BMS) and drug-eluting stents (DES). RESEARCH DESIGN AND METHODS Our population is represented by 6,298 ST-segment elevation myocardial infarction (STEMI) patients undergoing primary angioplasty included in the DESERT database from 11 randomized trials comparing DES with BMS. RESULTS Diabetes was observed in 972 patients (15.4%) who were older (P < 0.001), more likely to be female (P < 0.001), with higher prevalence of hypertension (P < 0.001), hypercholesterolemia (P < 0.001), and longer ischemia time (P < 0.001), and without any difference in angiographic and procedural characteristics. At long-term follow-up (1,201 ± 441 days), diabetes was associated with higher rates of death (19.1% vs. 7.4%; P < 0.0001), reinfarction (10.4% vs. 7.5%; P < 0.001), stent thrombosis (7.6% vs. 4.8%; P = 0.002) with similar temporal distribution—acute, subacute, late, and very late—between diabetic and control patients, and TVR (18.6% vs. 15.1%; P = 0.006). These results were confirmed in patients receiving BMS or DES, except for TVR, there being no difference observed between diabetic and nondiabetic patients treated with DES. The impact of diabetes on outcome was confirmed after correction for baseline confounding factors (mortality, P < 0.001; repeat myocardial infarction, P = 0.006; stent thrombosis, P = 0.007; TVR, P = 0.027). CONCLUSIONS This study shows that among STEMI patients undergoing primary angioplasty, diabetes is associated with worse long-term mortality, reinfarction, and stent thrombosis in patients receiving DES and BMS. DES implantation, however, does mitigate the known deleterious effect of diabetes on TVR after BMS.
Actigraphy in the critically ill: correlation with activity, agitation, and sedation.

OBJECTIVES To determine the feasibility of continuous measurement of limb movement via wrist and ankle actigraphy (an activity measure) in critically ill patients and to compare actigraphy measurements with observed activity, subjective scores on sedation-agitation scales, and heart rate and blood pressure of patients. METHODS In a prospective, descriptive, correlational study, all activity of 20 adult patients in medical and coronary care units in a university medical center were observed for 2 hours and documented. Wrist and ankle actigraphy, heart rate, and systolic and diastolic blood pressure data were collected every minute. The Comfort Scale and the Richmond Agitation-Sedation Scale were completed at the beginning of the observation period and 1 and 2 hours later. RESULTS Wrist actigraphy data correlated with scores on the Richmond Agitation-Sedation Scale (r = 0.58) and the Comfort Scale (r = 0.62) and with observed stimulation and activity events of patients (r = 0.45). Correlations with systolic, diastolic, and mean arterial pressures were weaker. Wrist and ankle actigraphy data were significantly correlated (r = 0.69; P < .001); however, their mean values (wrist, 418; ankle, 147) were significantly different (t = 5.77; P < .001). CONCLUSIONS Actigraphy provides a continuous recording of patients' limb movement. Actigraphy measurements correlate well with patients' observed activity and with subjective scores on agitation and sedation scales. Actigraphy may become particularly important as a continuous measurement of activity for use in behavioral research and may enhance early recognition and management of the excessive activity that characterizes agitation.
Towards a Decision Quality Model for Shot Selection in Basketball: an Exploratory Study

Abstract We take the first steps towards a shot selection quality model in basketball that incorporates decisional cues that might be predictive, not only of proximal results (e.g., scoring), but also of distal results (e.g., winning/losing the match). 2976 jump-shots from 50 Euroleague matches were sampled, following systematic observation guidelines. The decisional cues under scrutiny were shooting opposition, distance and lateral angle, disposition to offensive rebound and disposition to defensive balance at the moment of shooting. A first set of regressions between decisional cues and proximal results showed higher opposition and distance to decrease the probability of scoring (OR = .81; p < .001 and OR = .89; p = .013); a better disposition towards rebound to increase the chances of catching rebound (OR = 1.57; p < .001); and better defensive balance disposition to decrease the probability of a fast break (OR = 1.27; p < .036). A second set of regressions between proximal and distal results showed shooting and offensive rebound effectiveness to predict total points scored (β = .62; p < .001 and β = .32; p < .001) and game result (winning/losing the game; OR = 1.12; p < .001 and OR = 1.05; p = .021). Finally, an analysis of the impact of decisional cues on distal results showed a positive relationship between likelihood of winning and average team’s disposition to offensive rebound (OR = 1.18; p = .018). These results cast light on the actual weights (validities) of the different cues involved in predicting outcomes of shooting decisions. This evidence could help coaches provide objective feedback about players’ shooting performance beyond hit percentages.
Foot arch characterization: a review, a new metric, and a comparison.

BACKGROUND The medial longitudinal arch of the foot is important because it helps protect the foot from injury. Researchers have developed many measures to quantify the characteristics of the arch, and there is ongoing debate about the suitability of these different metrics. This article compares the various measures related to the foot arch, including a new metric, the midfoot dorsal angle, and then investigates the differences in the dimensional measures among various foot types. METHODS The right feet of 48 healthy individuals (24 men and 24 women) were measured, and various metrics, including the arch height index, the navicular height to arch length ratio, the arch index, the footprint index, the subjective ranking, the modified arch index, the malleolar valgus index, and the midfoot dorsal angle, were determined. RESULTS Correlation analyses showed that the arch index obtained from the inked footprint has a moderate to high correlation (Pearson correlation coefficients >0.50) with all measured foot-type metrics except for the malleolar valgus index. There were no differences in participant age, stature, weight, body mass index, foot length, foot width, and midfoot height among high, normal, and low foot arches. However, the high-arched group had significantly shorter arch lengths but larger navicular heights and higher midfoot dorsal angles compared with the low-arched group. There were differences in force distributions and peak pressures as well. The rearfoot had more loading and greater peak pressure whereas the midfoot had less load in the high-arched group compared with the low-arched group. CONCLUSIONS The midfoot dorsal angle may be an appropriate metric for characterizing the foot arch because it is quick and easy to measure, without the tedious procedures associated with area calculations and dimension measurements.
Endothelial proliferation, neoangiogenesis, and potential de novo generation of cerebrovascular malformations.

OBJECT To date, both arteriovenous malformations (AVMs) and cavernomas have been considered to be congenital malformations. A recent survey of the literature has shown the potential for de novo generation of both familial and sporadic cavernomas as well as AVMs. Therefore, it was of interest to determine the biological behavior of these lesions in detail. METHODS The proliferative and angiogenic capacities of the endothelium of 13 cavernomas and 25 AVMs obtained in patients recently treated (1997-1998) at one institution were studied. Immunohistochemical staining for proliferating cell nuclear antigen (PCNA), MIB-1, and vascular endothelial growth factor (VEGF) and its receptor Flk-1 was performed using standard staining procedures. Positive immunostaining of the nuclei of endothelial cells was observed in specimens of both AVMs and cavernomas for PCNA (80% of AVMs and 85% of cavernomas), and Flk-1 (80% of AVMs and 31% of cavernomas). Endothelial expression of VEGF in the 18 incompletely embolized AVMs was found in 72% of cases but only in 28% of the seven cases in which patients did not undergo endovascular treatment: it was found in 38% of cavernomas. Endothelial expression of MIB-1 was found in 12% of AVMs but in no cavernomas. CONCLUSIONS These results indicate that there is endothelial proliferation as well as neoangiogenesis in cerebral cavernomas and AVMs. The increased level of angiogenesis in only partially obliterated AVMs underscores the need for radical and complete occlusion of cerebral AVMs to avoid recurrences and further risks of morbidity.
Does the rural trauma team development course shorten the interval from trauma patient arrival to decision to transfer?

BACKGROUND The Rural Trauma Team Development Course (RTTDC) was developed by the ad hoc Rural Trauma Committee of the American College of Surgeons, Committee on Trauma to address the increased mortality of the rural trauma patient. The effectiveness of the RTTDC in shortening the interval from patient arrival to decision to transfer and the effect on the transfer process of communication training emphasizing team building is the focus of this study. METHOD Rural level III and level IV trauma centers (N=18) were enrolled in a multiinstitutional 3-month longitudinal study of transferred trauma patients. Results were compared with institutions having hosted RTTDC versus those institutions not yet exposed to the course. RESULTS One-way analysis of variance was conducted. Results indicated that RTTDC training alone and RTTDC including communication training resulted in a statistically significantly shorter (p<0.05) time for decision to transfer. Transferring squad arrival time was also significantly reduced (p<0.01) as was the number of transferring squads contacted (p<0.01). No differences were observed among the trauma facilities and the number of receiving facilities contacted, (p=0.64) or in the time required to find an accepting facility (p=0.72). CONCLUSION The RTTDC alone and with the embedded communication module significantly reduce delays in the transfer process of the rural trauma patient.
A Neuroplasticity Hypothesis of Chronic Stress in the Basolateral Amygdala

Chronic stress plays a role in the etiology of several affective and anxiety-related disorders. Despite this, its mechanistic effects on the brain are still unclear. Of particular interest is the effect of chronic stress on the amygdala, which plays a key role in the regulation of emotional responses and memory consolidation. This review proposes a neuroplasticity model for the effects of chronic stress in this region, emphasizing the roles of glutamate and BDNF signaling. This model provides a review of recent discoveries of the effects of chronic stress in the amygdala and reveals pathways for future research.