Miracle-dz/UniFAR-FTUs huggingface dataset:
Multisensory Integration With a Head-Mounted Display: Background Visual Motion and Sound Motion

Objective: The aim of this study was to assess how background visual motion and the relative movement of sound affect a head-mounted display (HMD) wearer’s performance at a task requiring integration of auditory and visual information. Background: HMD users are often mobile. A commercially available speaker in a fixed location delivers auditory information affordably to the HMD user. However, previous research has shown that mobile HMD users perform poorly at tasks that require integration of visual and auditory information when sound comes from a free-field speaker. The specific cause of the poor task performance is unknown. Method: Participants counted audiovisual events that required integration of sounds delivered via a free-field speaker and vision on an HMD. Participants completed the task while either walking around a room, sitting in the room, or sitting inside a mobile room that allowed separate manipulation of background visual motion and speaker motion. Results: Participants’ accuracy at counting target audiovisual events was worse when participants were walking than when sitting at a desk, p = . 032. Compared with when they were sitting at a desk, participants’ accuracy at counting target audiovisual events showed a trend to be worse when they experienced a combination of background visual motion and the relative movement of sound, p = . 058. Conclusion: Multisensory integration performance is least effective when HMD users experience a combination of background visual motion and relative movement of sound. Eye reflexes may play an important role. Application: Results apply to situations in which HMD wearers are mobile when receiving multimodal information, as in health care and military contexts.
Absorption and Metabolism Characteristics of Rutin in Caco-2 Cells

The intestinal absorption and metabolism characteristics of the potentially beneficial polyphenol rutin were studied by measuring the intracellular accumulation and transport of rutin into Caco-2 cells with the sensitive and reliable analytical method of HPLC-coupled tandem mass spectrometry. Rutin and glucuronidated rutin were absorbed differently by the basolateral and apical membranes, and rutin showed differential permeability through the apical and basolateral sides. Approximately 33% of the rutin was metabolized to glucuronidated rutin, and the intracellular concentration of glucuronidated rutin was much lower than that of parent rutin. P-glycoprotein and multidrug-resistant proteins 2 and 3 were involved in the transmembrane transport and intracellular accumulation of rutin by Caco-2 cells. These results suggest that a specific transport system mediates rutin movement across the apical membrane in Caco-2 cells and that metabolic enzymes are important for this process.
HST/WFC3 NEAR-INFRARED SPECTROSCOPY OF QUENCHED GALAXIES AT z ∼ 1.5 FROM THE WISP SURVEY: STELLAR POPULATION PROPERTIES

We combine Hubble Space Telescope (HST) G102 and G141 near-IR (NIR) grism spectroscopy with HST/WFC3-UVIS, HST/WFC3-IR, and Spitzer/IRAC [3.6 μm] photometry to assemble a sample of massive (log (Mstar/M☉) ∼ 11.0) and quenched (specific star formation rate <0.01 Gyr−1) galaxies at z ∼ 1.5. Our sample of 41 galaxies is the largest with G102+G141 NIR spectroscopy for quenched sources at these redshifts. In contrast to the local universe, z ∼ 1.5 quenched galaxies in the high-mass range have a wide range of stellar population properties. We find that their spectral energy distributions (SEDs) are well fitted with exponentially decreasing star formation histories and short star formation timescales (τ ⩽ 100 Myr). Quenched galaxies also show a wide distribution in ages, between 1 and 4 Gyr. In the (u − r)0-versus-mass space quenched galaxies have a large spread in rest-frame color at a given mass. Most quenched galaxies populate the z ∼ 1.5 red sequence (RS), but an important fraction of them (32%) have substantially bluer colors. Although with a large spread, we find that the quenched galaxies on the RS have older median ages (3.1 Gyr) than the quenched galaxies off the RS (1.5 Gyr). We also show that a rejuvenated SED cannot reproduce the observed stacked spectra of (the bluer) quenched galaxies off the RS. We derive the upper limit on the fraction of massive galaxies on the RS at z ∼ 1.5 to be <43%. We speculate that the young quenched galaxies off the RS are in a transition phase between vigorous star formation at z > 2 and the z ∼ 1.5 RS. According to their estimated ages, the time required for quenched galaxies off the RS to join their counterparts on the z ∼ 1.5 RS is of the order of ∼1 Gyr.
Optimised Multiplication Architectures for Accelerating Fully Homomorphic Encryption

Large integer multiplication is a major performance bottleneck in fully homomorphic encryption (FHE) schemes over the integers. In this paper two optimised multiplier architectures for large integer multiplication are proposed. The first of these is a low-latency hardware architecture of an integer-FFT multiplier. Secondly, the use of low Hamming weight (LHW) parameters is applied to create a novel hardware architecture for large integer multiplication in integer-based FHE schemes. The proposed architectures are implemented, verified and compared on the Xilinx Virtex-7 FPGA platform. Finally, the proposed implementations are employed to evaluate the large multiplication in the encryption step of FHE over the integers. The analysis shows a speed improvement factor of up to 26.2 for the low-latency design compared to the corresponding original integer-based FHE software implementation. When the proposed LHW architecture is combined with the low-latency integer-FFT accelerator to evaluate a single FHE encryption operation, the performance results show that a speed improvement by a factor of approximately 130 is possible.
Growth Factors , Cytokines , Cell Cycle Molecules Revisiting the Koebner Phenomenon Role of NGF and Its Receptor System in the Pathogenesis of Psoriasis

Nerve growth factor (NGF) influences the key pathological events of psoriasis: keratinocyte proliferation, angiogenesis, and T-cell activation. We have systematically examined the kinetics of NGF expression, keratinocyte proliferation, and migration of T lymphocytes in the epidermis in Koebner-induced developing psoriatic plaques. In skin traumatized by the tape-stripping method (n 12), a marked up-regulation of NGF in Koebner-positive lesions (n 7) was observed 24 hours after trauma. Synthesis of NGF reached its maximum level in the 2nd week. Furthermore, cultured keratinocytes from nonlesional skin of psoriasis patients produced 10 times higher levels of NGF compared with keratinocytes from healthy individuals. To substantiate the in vivo effect of NGF secreted by keratinocytes in psoriatic plaques, we studied psoriatic plaques and normal human skin in a SCID-human skin xenograft model. The transplanted psoriatic plaques demonstrated marked proliferation of NGF-R (p75)-positive nerve fibers compared with only a few nerves in the transplanted normal human skin. Our results demonstrate that 1) in a developing psoriatic lesion, up-regulation of NGF together with keratinocyte proliferation are early events and precede epidermotropism of T lymphocytes; 2) keratinocytes in patients with psoriasis are primed to produce elevated levels of NGF; and 3) NGF synthesized by these keratinocytes is functionally active. (Am J Pathol 2008, 172:961–971; DOI: 10.2353/ajpath.2008.070710)
Epidemiology of chronic obstructive pulmonary disease: a population-based study in Krasnoyarsk region, Russia

Background Krasnoyarsk region is a territory with the widespread risk factors for chronic obstructive pulmonary disease (COPD) such as tobacco smoke, air pollution, and occupational exposure. An assessment of COPD prevalence based on medical diagnosis statistics underestimates the true COPD prevalence. This study aims to evaluate how medical examinations may increase the accuracy of estimates of COPD prevalence. Methods True COPD prevalence was estimated as a number of patients with the established disease diagnosis supplemented by the additional disease cases detected during medical examinations per 1,000 inhabitants of the region. Official medical statistics data and the data collected from the Global Alliance against Chronic Respiratory Diseases program 2011 among 15,000 inhabitants of the region aged 18 years and older were analyzed. Results This study revealed the COPD cases without official medical diagnosis. The true prevalence of COPD is estimated to be two times higher than the prevalence estimates based on medical diagnosis statistics. Conclusion Undiagnosed and untreated cases of COPD result in severe COPD forms as well as addition of severe comorbidities. Because of this, there is an increase in the index of potential years of life lost. Conducting special medical examinations may increase the number of COPD cases detected at the early stages of the disease. This, in turn, may reduce the overall burden of the disease for the population of the region.
STUDIES OF TWO KINDS OF VIRUS PARTICLES WHICH COMPRISE INFLUENZA A2 VIRUS STRAINS

Two kinds of virus particles have been found in varying proportions in influenza A2 strains isolated during the 1957 pandemic. Pure populations of the different particles were obtained, and these substrains were genetically stable on serial passage in the chick embryo. The two virus particles differ markedly in several biological properties though they are antigenically similar. One kind of particle, designated "+," is relatively sensitive to specific antibody, is highly sensitive to inhibition by serum inhibitors and urinary mucoprotein, fails to elute or elutes very slowly from human erythrocytes, and is capable of agglutinating erythrocytes treated extensively with V. cholerae filtrate. The other particle, designated "-," is relatively insensitive to antibodies and urinary mucoprotein, completely insensitive to serum inhibitors, elutes rapidly from erythrocytes, and can agglutinate erythrocytes treated extensively with V. cholerae filtrate. Both "+" and "-" particles destroy virus receptors on urinary mucoprotein. The relative proportions of these two particles determine the characteristics of parent strains in reactions with specific antibody, mucoprotein inhibitors, and erythrocytes. The "+" and "-" particles with several easily identifiable markers are well suited for genetic studies.
Effects of Combination of Angiotensin Receptor Blocker and Calcium Channel Blocker on Ox-LDL Levels and Cardiovascular Dysfunction in Dahl Rats

In an effort to assess the cardiovascular benefits of combined angiotensin receptor blockage and calcium channel antagonism, we assessed the chronic effects of the angiotensin type 1 receptor blocker candesartan, the calcium channel blocker benidipine, and the use of a combination therapy in Dahl salt-sensitive (DS) rats. DS rats receiving a high salt diet were treated with either benidipine (4 mg/kg), candesartan (1 mg/kg) or both. Rat blood pressure was measured using a tail-cuff method. Following 12 weeks, the effect on heart weight, plasma-oxidized low-density lipoprotein (ox-LDL) level, endothelium-dependent vasorelaxation, and histology of the heart and aorta was assessed. Blood pressure, heart weight and plasma ox-LDL levels increased, while endothelium-dependent vasorelaxation decreased in the DS rats. Candesartan and benidipine inhibited the increase in blood pressure and heart weight, and the decrease in endothelium-dependent vasorelaxation. The use of benidipine alone or a combination significantly inhibited the increase in ox-LDL levels, whereas candesartan alone had no significant effect on ox-LDL levels. The present findings indicate that, if the monotherapy using ARB could not achieve adequate control of blood pressure, the combination therapy with ARB and benidipine provides the additional reductions in hypertension and cardiac hypertrophy. Moreover, the combination therapy inhibits cardiovascular dysfunction and ox-LDL levels more effectively than use of ARB alone. These results contribute to the possibility of lowering ox-LDL levels as a means of enhancing cardiovascular protection.
High resolution cell lineage tracing reveals developmental variability in leech

Knowing the normal patterns of embryonic cell proliferation, migration, and differentiation is a cornerstone for understanding development. Yet for most species, the precision with which embryonic cell lineages can be determined is limited by technical considerations (the large numbers of cells, extended developmental times, opacity of the embryos), and these are exacerbated by the inherent variability of the lineages themselves. Here, we present an improved method of cell lineage tracing in the leech Helobdella, driving the expression of a nuclearly localized histone H2B:GFP (green fluorescent protein) fusion protein in selected lineages by microinjection of a plasmid vector. This construct generates a long lasting and minimally mosaic signal with single cell resolution, and does not disrupt the development of most lineages tested. We have validated this technique by elucidating details of cell lineages contributing to segmental and prostomial tissues that could not be observed with standard dextran lineage tracers. Developmental Dynamics 238:3139–3151, 2009. © 2009 Wiley‐Liss, Inc.
Triple Engine Processor (TEP)

The advent of 3D memory stacking technology, which integrates a logic layer and stacked memories, is expected to be one of the most promising memory technologies to mitigate the memory wall problem by leveraging the concept of near-memory processing (NMP). With the ability to process data locally within the logic layer of stacked memory, a variety of emerging big data applications can achieve significant performance and energy-efficiency benefits. Various approaches to the NMP logic layer architecture have been studied to utilize the advantage of stacked memory. While significant acceleration of specific kernel operations has been derived from previous NMP studies, an NMP-based system using an NMP logic architecture capable of handling some specific kernel operations can suffer from performance and energy efficiency degradation caused by a significant communication overhead between the host processor and NMP stack. In this article, we first analyze the kernel operations that can greatly improve the performance of NMP-based systems in diverse emerging applications, and then we analyze the architecture to efficiently process the extracted kernel operations. This analysis confirms that three categories of processing engines for NMP logic are required for efficient processing of a variety of emerging applications, and thus we propose a Triple Engine Processor (TEP), a heterogeneous near-memory processor with three types of computing engines. These three types of engines are an in-order core, a coerce-grain reconfigurable processor (CGRA), and dedicated hardware. The proposed TEP provides about 3.4 times higher performance and 33% greater energy savings than the baseline 3D memory system.
Caspase 2 Activity Contributes to the Initial Wave of Germ Cell Apoptosis During the First Round of Spermatogenesis1

Abstract Early in postnatal life the first phase of spermatogenesis is accompanied by an initial wave of germ cell apoptosis. This wave of germ cell death is thought to reflect an adjustment of germ cell numbers that can be adequately maintained by Sertoli cells. Caspase 2 is an initiator caspase whose activation has been found to stimulate apoptosis through the mitochondria. The present study investigates if germ cell apoptosis during the first phase of spermatogenesis involves activation of caspase 2. Germ cell apoptosis was found to peak at Postnatal Days (pnds) 15 and 16 in male C57BL/6 mice. Western blot analysis revealed that caspase 2 also increased in the testes at pnd 16. Immunolocalization of total caspase 2 showed staining of germ cells in the periphery of the seminiferous tubules as well as germ cells more centrally located in an area where apoptotic germ cells were observed. Cytoplasmic as well as nuclear staining was observed. Western blot analysis of cytoplasmic and nuclear proteins from pnd 16 testis revealed pro-caspase 2 in both fractions. Further Western blot analysis for caspase 2 detected an increase in the activation of caspase 2 at pnd 16 in proteins isolated from the cytoplasm but not from the nucleus. Proteins isolated from mitochondria from pnd 16 testes revealed an increase in pro-caspase 2 as well as activated caspase 2 corresponding with an increase in cytochrome c in cytoplasmic fractions. Injection of the caspase 2-specific inhibitor z-VDVAD-fmk directly into the testis significantly reduced the observed germ cell apoptosis at pnds 15 and 16. These results suggest that caspase 2 is present in germ cells in the murine testis in early postnatal life and increases in expression in correspondence to the initial wave of germ cell apoptosis. Caspase 2 also localizes to mitochondria, where it is correlated with a release of cytochrome c and germ cell apoptosis. Blockade of caspase 2 activation reduced the number of apoptotic germ cells in the initial wave of germ cell apoptosis, indicating that caspase 2 plays an important role upstream of the mitochondria in germ cell apoptosis during the first phase of spermatogenesis.
Conditioned fear-induced changes in behavior and in the expression of the immediate early gene c-fos: with and without diazepam pretreatment

The synthesis of Fos, the protein product of the immediate early gene c- fos, was used to map metabolically some of the neural substrates of conditioned fear in the rat. Analysis of the behaviors emitted by the rats during the test session provided strong evidence that the conditioning procedure was effective. Exposure to the environment in which they had previously received footshock significantly increased the number of Fos-like immunoreactive neurons in nearly 50 brain regions, both cortical and subcortical. Among the structures showing the most dramatic increases in fear-induced c-fos expression were the cingulate, piriform, infralimbic, and retrosplenial cortices, the anterior olfactory nucleus, claustrum, endopiriform nucleus, nucleus accumbens shell, lateral septal nucleus, various amygdalar nuclei, paraventricular thalamic nucleus, ventral lateral geniculate nucleus, the ventromedial, lateral, and dorsal hypothalamic nuclei, the ventral tegmental area, and the supramammillary area. These data demonstrate that a relatively simple classical conditioning procedure activates a large number of widely dispersed cortical and subcortical structures. Some of the structures showing increased c-fos expression have important autonomic functions and may therefore have reflected centrally mediated changes in blood pressure and respiration produced by the anxiogenic stimuli. In a second experiment, the effects of pretreatment with the anxiolytic drug diazepam (2.5, 5.0, or 10 mg/kg) were evaluated. The benzodiazepine produced dose-related decreases in the frequency of crouching (freezing) elicited by the aversively conditioned contextual cues. Diazepam also produced dose-related decreases in conditioned stress-induced c-fos expression in all but one structure, the effects being statistically significant in 38 of 60 sampled structures. Diazepam dose dependently increased fear-induced c- fos expression in the central nucleus of the amygdala. There was considerable regional variability with respect to sensitivity to diazepam, the retrosplenial cortex and the supramammillary area being the only two structures to show decreases after the lowest dose of diazepam. In contrast, the entorhinal cortex, nucleus accumbens core, ventromedial and posterior hypothalamic nuclei, median raphe, and locus coeruleus were particularly resistant to diazepam, all failing to show statistically significant decreases in conditioned fear-induced c-fos expression even at the highest dose. The extent to which diazepam decreased conditioned stress-induced c-fos expression was unrelated to previous estimates of benzodiazepine receptor density in the sampled structures.
AUTOMORPHISM GROUPS OF RIEMANN SURFACES OF GENUS p+1, WHERE p IS PRIME

We show that if $\mathcal S$ is a compact Riemann surface of genus $g=p+1$, where $p$ is prime, with a group of automorphisms $G$ such that $|G|\geq\lambda(g-1)$ for some real number $\lambda>6$, then for all sufficiently large $p$ (depending on $\lambda$), $\mathcal S$ and $G$ lie in one of six infinite sequences of examples. In particular, if $\lambda=8$ then this holds for all $p\geq 17$.
Parametricity and Proving Free Theorems for Functional-Logic Languages

The goal of this paper is to provide the required foundations for establishing free theorems -- statements about program equivalence, guaranteed by polymorphic types -- for the functional-logic programming language Curry. For the sake of presentation we restrict ourselves to a language fragment that we call CuMin, and that has the characteristic features of Curry (both functional and logic). We present a new denotational semantics based on partially ordered sets without limits. We then introduce an intermediate language called SaLT that is essentially a lambda-calculus extended with an abstract set type, and again give a denotational semantics. We show that the standard (logical relations) techniques can be applied to obtain a general parametricity theorem for SaLT and derive free theorems from it. Via a translation from CuMin to SaLT that fits the respective semantics, we then derive free theorems for CuMin.
Matching of Tracked Pedestrians Across Disjoint Camera Views Using CI-DLBP

Matching pedestrians across disjoint camera views is a challenging task, since their observations are separated in time and space and their appearances may vary considerably. Recently, some approaches of matching pedestrians have been proposed. However, these approaches either used too complex representations or only considered the color information and discarded the spatial structural information of the pedestrian. In order to describe the spatial structural information in color space, we propose a distance-based local binary pattern (DLBP) descriptor. Besides the spatial structural information, the color itself namely its intensity value is also an important feature in matching pedestrians across disjoint camera views. In order to effectively combine these two kinds of information, we further propose a novel CI_DLBP descriptor, which unifies the color intensity and DLBP by learning the joint distributions (2-D histograms) of the DLBP and color intensity at each channel. In addition, different from the previous approaches in which the pedestrians matching is based on their whole bodies, we develop a part-based pedestrian representation because the color density and spatial structural information between the upper outer garment and the lower garment worn by the pedestrian is usually different. Experimental results on challenging realistic scenarios and VIPeR dataset validate the proposed DLBP operator, the CI_DLBP descriptor, and the part-based pedestrian representation for pedestrian matching across disjoint camera views. Compared with existing methods based on color information, this new CI_DLBP approach performs better.