Miracle-dz/UniFAR-FTUs huggingface dataset:
The effect of musicianship on pitch memory in performance matched groups

We compared brain activation patterns between musicians and non-musicians (matched in performance score) while they performed a pitch memory task (using a sparse temporal sampling fMRI method). Both groups showed bilateral activation of the superior temporal, supramarginal, posterior middle and inferior frontal gyrus, and superior parietal lobe. Musicians showed more right temporal and supramarginal gyrus activation while non-musicians had more right primary and left secondary auditory cortex activation. Since both groups' performance were matched, these results probably indicate processing differences between groups that are possibly related to musical training. Non-musicians rely more on brain regions important for pitch discrimination while musicians prefer to use brain regions specialized in short-term memory and recall to perform well in this pitch memory task.
Dynamic Analysis of Current-Voltage Characteristics of Nanoscale Gated-Thyristors

This letter presents a detailed experimental investigation of the current-voltage characteristics of deca-nanometer gated-thyristors, highlighting that strong differences exist between the static and the dynamic operation of these devices. In particular, results reveal that the forward-breakover voltage determining thyristor turn-on does not depend only on the applied gate voltage, but also on the rise time of the applied gate pulse, decreasing for fast pulse fronts. This is explained in terms of a higher electron injection from the cathode to the anode triggering device turn-on when the gate switching time is shorter than that required for holes to leave the p-base.
Ieee/acm Transactions on Computational Biology and Bioinformatics

— This paper proposes new algorithms for computing pairwise rearrangement scenarios that conserve the combina-torial structure of genomes. More precisely, we investigate the problem of sorting signed permutations by reversals without breaking common intervals. We describe a combinatorial framework for this problem that allows to characterize classes of signed permutations for which one can compute in polynomial time a shortest reversal scenario that conserves all common intervals. In particular we define a class of permutations for which this computation can be done in linear time with a very simple algorithm that does not rely on the classical Hannenhalli-Pevzner theory for sorting by reversals. We apply these methods to the computation of rearrangement scenarios between permutations obtained from 16 synteny blocks of the X chromosomes of the human, mouse and rat.
Development brings scalability to hardware evolution

The scalability problem is a major impediment to the use of hardware evolution for real-world circuit design problems. A potential solution is to model the map between genotype and phenotype on biological development. Although development has been shown to improve scalability for a few toy problems, it has not been demonstrated for any circuit design problems. This paper presents such a demonstration for two problems, the n-bit adder with carry and even n-bit parity problems, and shows that development imposes, and benefits from, fewer constraints on evolutionary innovation than other approaches to scalability.
Market Microstructure: Theory and Empirics

This paper reviews the literature on market microstructure. Particular emphasis is given to the research dealing with the impact that a specific trading mechanism might have on price behaviour and with the comparison of the performance of alternative market structures. Theoretical models and empirical studies investigating their implications are explored. The major statistical properties and reguliarities of microstructural data are discussed.
Stat5 and Sp1 Regulate Transcription of the Cyclin D2 Gene in Response to IL-21

The IL-2R promotes rapid expansion of activated T cells through signals mediated by the adaptor protein Shc and the transcription factor Stat5. The mechanisms that engage the cell cycle are not well defined. We report on the transcriptional regulation of the cell cycle gene cyclin D2 by the IL-2R. IL-2-responsive induction of a luciferase reporter gene containing 1624 bp of the cyclin D2 promoter/enhancer was studied in the murine CD8+ T cell line CTLL2. Reporter gene deletional analysis and EMSAs indicate an IL-2-regulated enhancer element flanks nucleotide −1204 and binds a complex of at least three proteins. The enhancer element is bound constitutively by Sp1 and an unknown factor(s) and inducibly by Stat5 in response to IL-2. The Stat5 binding site was essential for IL-2-mediated reporter gene activity, and maximum induction required the adjacent Sp1 binding site. Receptor mutagenesis studies in the pro-B cell line BA/FG (a derivative of the BA/F3 cell line) demonstrated a correlation between Stat5 activity and cyclin D2 mRNA levels when the Stat5 signal was isolated, disrupted, and then rescued. Further, a dominant-negative form of Stat5 lacking the trans-activation domain inhibited induction of cyclin D2 mRNA. We propose that the IL-2R regulates the cyclin D2 gene in part through formation of an enhancer complex containing Stat5 and Sp1.
Generation of n-scroll attractors via sine function

A new approach for generating n-scroll attractors is introduced. It is demonstrated that n-scroll attractors can be generated using a simple sine or cosine function. A guideline is given so that a different number of scrolls can be designed easily by modifying two variables in the function. An electronic circuit is also designed for the implementation and the observation of a 9-scroll attractor is reported for the first time.
Experimental cross section of 144Sm(α, γ)148Gd and implications for the p-process

The cross section of the 144 Sm(;) 148 Gd reac- tion has been measured at bombarding energies in the 10.5- 13.4 MeV range using an activation method based on the off-line -activity measurement of the 148 Gd residual nucleus. The long measuring time of the -decay has required the use of etched track detectors. The resulting cross sections and astrophysical S-factors are compared to new statistical model calculations. The measured data at low energies reflect the strong energy dependence of the optical potential which is found to affect significantly our predictions of the -capture rate.
Methods and Instruments to Evaluate Cognitive Function in Chronic Pain Patients: A Systematic Review.

OBJECTIVE We aimed to systematically review the methods and instruments used to evaluate cognitive function in chronic pain (CP) patients. METHODS A sensitive search strategy was designed using five databases. Based on the objectives and methodology, we selected cross-sectional studies on adults with chronic non-cancer pain in which cognitive function was assessed using validated instruments. The characteristics of the subjects, control groups, and other variables that might affect cognitive function, and the instruments used, were extracted from each article. RESULTS In the 42 articles identified, 53 instruments were used to assess cognitive function. Chronic pain criteria were defined in 83.3% of the articles and more than half (57.1%) included single diagnosis samples, with fibromyalgia being the most frequent studied (75%). Patients with prior cognitive impairment were excluded in 61.9% of the studies, and a control group was included in 64.3% of the studies. In most cases potential confounding variables were evaluated. More than 14% of the studies used self-report measures, and 73.8% used neuropsychological instruments, particularly for assessing attention (30%) and memory (27.5%). None of the instruments were specifically validated for pain patients and only five studies analyzed the psychometric properties of the instruments. CONCLUSIONS Various instruments and methods were used to assess cognitive function in CP patients, particularly fibromyalgia patients, but also other cohorts with well-defined CP. The instruments used had been validated, but not for pain populations, thus they require specific adaptation and validation to be used in CP patients. Certain recommendations are made in order to improve the evaluation of cognitive function in these patients.
Reversors and Symmetries for Polynomial Automorphisms of the Plane

We obtain normal forms for symmetric and for reversible polynomial automorphisms (polynomial maps that have polynomial inverses) of the plane. Our normal forms are based on the generalized Hénon normal form of Friedland and Milnor. We restrict to the case that the symmetries and reversors are also polynomial automorphisms. We show that each such reversor has finite-order, and that for nontrivial, real maps, the reversor has order 2 or 4. The normal forms are shown to be unique up to finitely many choices. We investigate some of the dynamical consequences of reversibility, especially for the case that the reversor is not an involution.
Comparison of cytosolic and nuclear poly(A) polymerases from rat liver and a hepatoma: structural and immunological properties and response to NI-type protein kinases.

Poly(A) polymerases were purified from the cytosol fraction of rat liver and Morris hepatoma 3924A and compared to previously purified nuclear poly(A) polymerases. Chromatographic fractionation of the hepatoma cytosol on a DEAE-Sephadex column yielded approximately 5 times as much poly(A) polymerase as was obtained from fractionation of the liver cytosol. Hepatoma cytosol contained a single poly(A) polymerase species [48 kilodaltons (kDa)] which was indistinguishable from the hepatoma nuclear enzyme (48 kDa) on the basis of CNBr cleavage maps. Liver cytosol contained two poly(A) polymerase species (40 and 48 kDa). The CNBr cleavage patterns of these two enzymes were distinct from each other. However, the cleavage pattern of the 40-kDa enzyme was similar to that of the major liver nuclear poly(A) polymerase (36 kDa), and approximately three-fourths of the peptide fragments derived from the 48-kDa species were identical with those from the hepatoma enzymes (48 kDa). NI-type protein kinases from liver or hepatoma stimulated hepatoma nuclear and cytosolic poly(A) polymerases 4-6-fold. In contrast, the liver cytosolic 40- and 48-kDa poly(A) polymerases were stimulated only slightly or inhibited by similar units of the protein kinases. Antibodies produced in rabbits against purified hepatoma nuclear poly(A) polymerase reacted equally well with hepatoma nuclear and cytosolic enzyme but only 80% as well with the liver cytosolic 48-kDa poly(A) polymerase and not at all with liver cytosolic 40-kDa or nuclear 36-kDa enzymes. Anti-poly(A) polymerase antibodies present in the serum of a hepatoma-bearing rat reacted with hepatoma nuclear and cytosolic poly(A) polymerases to the same extent but only 40% as well with the liver cytosolic 48-kDa enzyme. (ABSTRACT TRUNCATED AT 250 WORDS)
Composing Functional and State-Based Performance Models for Analyzing Heterogeneous Real-Time Systems

We present a performance analysis technique for distributed real-time systems in a setting where certain components are modeled in a purely functional manner, while the remaining components require additional modeling of state information. The functional models can be efficiently analyzed but have restricted expressiveness. On the other hand, state-based models are more expressive and offer a richer set of analyzable properties but are computationally more expensive to analyze. We show that by appropriately composing these two classes of models it is possible to leverage on their respective advantages. To this end, we propose an interface between components that are modeled using real-time calculus [Chakraborty, Kiinzli and Thiele, DATE 2003] and those that are modeled using event count automata [Chakraborty, Phan and Thiagarajan, RTSS 2005]. The resulting modeling technique is as expressive as event count automata, but is amenable to more efficient analysis. We illustrate these advantages using a number of examples and a detailed case study.
Semantic‐Preserving Word Clouds by Seam Carving

Word clouds are proliferating on the Internet and have received much attention in visual analytics. Although word clouds can help users understand the major content of a document collection quickly, their ability to visually compare documents is limited. This paper introduces a new method to create semantic‐preserving word clouds by leveraging tailored seam carving, a well‐established content‐aware image resizing operator. The method can optimize a word cloud layout by removing a left‐to‐right or top‐to‐bottom seam iteratively and gracefully from the layout. Each seam is a connected path of low energy regions determined by a Gaussian‐based energy function. With seam carving, we can pack the word cloud compactly and effectively, while preserving its overall semantic structure. Furthermore, we design a set of interactive visualization techniques for the created word clouds to facilitate visual text analysis and comparison. Case studies are conducted to demonstrate the effectiveness and usefulness of our techniques.
Factors Affecting the Pullout Strength of Self-Drilling and Self-Tapping Anterior Cervical Screws

Study design. A biomechanical comparison of 12-, 14-, and 16-mm self-tapping and self-drilling screws in cadaveric cervical spines was performed. Objective. This study compared self-drilling and self-tapping screw designs used in anterior cervical locking plates in terms of insertion torque and pullout strength. In addition to screw design, the effects of screw length (12, 14, and 16 mm) and bone mineral density were examined. Methods. A total of 201 screws were implanted and tested. Nineteen cadaver spine specimens (C2 through C7) were radiographed and their bone mineral density measured. In each vertebral level, two screws of the same length were implanted and their insertion torque measured. One of each screw design (self-drilling or self-tapping) was randomly placed in each vertebra for side-by-side comparison. Vertebrae then were individually potted and mounted on an MTS machine for accurate measurement of maximum pullout strength. Results. Pullout strength was strongly related to screw length (P = 0.0002). There was no significant difference in pullout strength between the self-drilling and self-tapping screw designs at any length (P = 0.9352). A significant correlation (P ≤ 0.0077) exists between insertion torque and bone mineral density for the self-drilling and self-tapping 14- and 16-mm screws. A significant correlation exists between pullout strength and bone mineral density for 14- and 16-mm screw lengths of both screw types (P < 0.0001). Conclusions. It would appear that the longest screw feasible should always be used clinically for maximum pullout strength. There is no difference in pullout strength between self-drilling and self-tapping screws. Bone mineral density significantly influences screw performance.
ATP-Binding Cassette Transport System Involved in Regulation of Morphological Differentiation in Response to Glucose in Streptomyces griseus

ABSTRACT Streptomyces griseus NP4, which was derived by UV mutagenesis from strain IFO13350, showed a bald and wrinkled colony morphology in response to glucose. Mutant NP4 formed ectopic septa at intervals along substrate hyphae, and each of the compartments developed into a spore which was indistinguishable from an aerial spore in size, shape, and thickness of the spore wall and in susceptibility to lysozyme and heat. The ectopic spores of NP4 formed in liquid medium differed from “submerged spores” in lysozyme sensitivity. Shotgun cloning experiments with a library of the chromosomal DNA of the parental strain and mutant NP4 as the host gave rise to DNA fragments giving two different phenotypes; one complementing the bald phenotype of the host, and the other causing much severe wrinkled morphology in the host. Subcloning identified a gene (dasR) encoding a transcriptional repressor belonging to the GntR family that was responsible for the reversal of the bald phenotype and a gene (dasA) encoding a lipoprotein probably serving as a substrate-binding protein in an ATP-binding cassette (ABC) transport system that was responsible for the severe wrinkled morphology. These genes were adjacent but divergently encoded. Two genes, named dasB and dasC, encoding a membrane-spanning protein were present downstream of dasA, which suggested that dasRABC comprises a gene cluster for an ABC transporter, probably for sugar import. dasR was transcribed actively during vegetative growth, and dasA was transcribed just after commencement of aerial hypha formation and during sporulation, indicating that both were developmentally regulated. Transcriptional analysis and direct sequencing of dasRA in mutant NP4 suggested a defect of this mutant in the regulatory system to control the expression of these genes. Introduction of multicopies of dasA into the wild-type strain caused ectopic septation in very young substrate hyphae after only 1 day of growth and subsequent sporulation in response to glucose. The ectopic spores of the wild type had a thinner wall than those of mutant NP4, in agreement with the observation that the former was sensitive to lysozyme and heat. Disruption of the chromosomal dasA or dasR in the wild-type strain resulted in growth as substrate mycelium, suggesting an additional role of these genes in aerial mycelium formation. The ectopic septation and sporulation in mutant NP4 and the wild-type strain carrying multicopies of dasA were independent of a microbial hormone, A-factor (2-isocapryloyl-3R-hydroxymethyl-γ-butyrolactone), that acts as a master switch of aerial mycelium formation and secondary metabolism.
Initiation of triple therapy maintenance treatment among patients with COPD in the US

Background The Global Initiative for Chronic Obstructive Lung Disease (GOLD) recommends triple therapy (long-acting muscarinic receptor antagonists, long-acting beta-2 agonists, and inhaled corticosteroids) for patients with only the most severe COPD. Data on the proportion of COPD patients on triple therapy and their characteristics are sparse and dated. Objective 1 of this study was to estimate the proportion of all, and all treated, COPD patients receiving triple therapy. Objective 2 was to characterize those on triple therapy and assess the concordance of triple therapy use with GOLD guidelines. Patients and methods This retrospective study used claims from the IMS PharMetrics Plus database from 2009 to 2013. Cohort 1 was selected to assess Objective 1 only; descriptive analyses were conducted in Cohort 2 to answer Objective 2. A validated claims-based algorithm and severity and frequency of exacerbations were used as proxies for COPD severity. Results Of all 199,678 patients with COPD in Cohort 1, 7.5% received triple therapy after diagnosis, and 25.5% of all treated patients received triple therapy. In Cohort 2, 30,493 COPD patients (mean age =64.7 years) who initiated triple therapy were identified. Using the claims-based algorithm, 34.5% of Cohort 2 patients were classified as having mild disease (GOLD 1), 40.8% moderate (GOLD 2), 22.5% severe (GOLD 3), and 2.3% very severe (GOLD 4). Using exacerbation severity and frequency, 60.6% of patients were classified as GOLD 1/2 and 39.4% as GOLD 3/4. Conclusion In this large US claims database study, one-quarter of all treated COPD patients received triple therapy. Although triple therapy is recommended for the most severe COPD patients, spirometry is infrequently assessed, and a majority of the patients who receive triple therapy may have only mild/moderate disease. Any potential overprescribing of triple therapy may lead to unnecessary costs to the patient and health care system.
Evaluation of LightCycler PCR for Implementation of Laboratory Diagnosis of Herpes Simplex Virus Infections

ABSTRACT Five hundred specimens (288 genital, 192 dermal, and 20 ocular) were extracted by technologists, and the DNA was assayed by LightCycler PCR (DNA polymerase and thymidine kinase [TK] gene targets) and by conventional tube and shell vial cell culture. One hundred fifty-eight confirmed (by cell culture and TK target PCR) positive and LightCycler-positive specimens were detected during the first 30 PCR cycles. LightCycler PCR-positive results for cycles 31 to 45 (39 of 67 [58.2%]) required confirmation by another PCR target (TK). LightCycler PCR is more sensitive (n = 197; 23.1%) than cell cultures (n = 150) for the routine laboratory detection of herpes simplex virus infections.
Positive feedback, memory, and the predictability of earthquakes

We review the “critical point” concept for large earthquakes and enlarge it in the framework of so-called “finite-time singularities. ” The singular behavior associated with accelerated seismic release is shown to result from a positive feedback of the seismic activity on its release rate. The most important mechanisms for such positive feedback are presented. We solve analytically a simple model of geometrical positive feedback in which the stress shadow cast by the last large earthquake is progressively fragmented by the increasing tectonic stress.
Impact of Building Environment on the Performance of Dynamic Indoor Localization

Location determination of mobile users within a building is challenging due to the complexities of the indoor radio propagation characteristics. For a RF based indoor system, a common practice is to construct a signal strength map table showing the radio signal strength at different known locations in the building. A mobile user's location at an arbitrary point in the building is then determined by measuring the signal strength at the location in question and determining the location by referring to the above map table using a LMSE (least mean square error) criterion. Much work has been done lately in the indoor radio propagation in order to automatically generate the signal strength map table according to the changing environment. This research is based on the ARIADNE indoor localization system with the purpose to analyze the impact of building structures and indoor furniture on the performance of the indoor localization. We provide a simple strategy to model these indoor structures, and we verify the methodology using a complex basement building. Experimental results indicate that up to 15% improvement in location estimation is achievable from the proposed method
Commentary: Chronic SSRI stimulation of astrocytic 5-HT2B receptors change multiple gene expressions/editings and metabolism of glutamate, glucose and glycogen: a potential paradigm shift

Working on the serotonin (5-hydroxytryptamine, 5-HT) 5-HT2B receptor since several years, we have read with high interest the review by Hertz et al. (2015). Previous studies from our group demonstrated that a direct injection in mouse raphe nucleus of the 5-HT2B agonist BW723C86 has the ability to increase extracellular levels of serotonin, which can be blocked by the selective 5-HT2B receptor antagonist RS127445 (Doly et al., 2008, 2009). We also reported that an acute injection of paroxetine 2 mg/kg in mice knocked out for the 5-HT2B receptor gene or in wild type mice injected with RS127445 (0.5 mg/kg) triggers a strong reduction in extracellular accumulation of 5-HT in hippocampus (Diaz et al., 2012). Following these observations, we showed that acute and chronic BW723C86 injection (3 mg/kg) can mimic the fluoxetine (3 mg/kg) and paroxetine (1 mg/kg) behavioral and biochemical antidepressant effects in mice (Diaz and Maroteaux, 2011; Diaz et al., 2012).