Miracle-dz/UniFAR-FTUs huggingface dataset:
Targeted expression of MYCN causes neuroblastoma in transgenic mice

The proto‐oncogene MYCN is often amplified in human neuroblastomas. The assumption that the amplification contributes to tumorigenesis has never been tested directly. We have created transgenic mice that overexpress MYCN in neuroectodermal cells and develop neuroblastoma. Analysis of tumors by comparative genomic hybridization revealed gains and losses of at least seven chromosomal regions, all of which are syntenic with comparable abnormalities detected in human neuroblastomas. In addition, we have shown that increases in MYCN dosage or deficiencies in either of the tumor suppressor genes NF1 or RB1 can augment tumorigenesis by the transgene. Our results provide direct evidence that MYCN can contribute to the genesis of neuroblastoma, suggest that the genetic events involved in the genesis of neuroblastoma can be tumorigenic in more than one chronological sequence, and offer a model for further study of the pathogenesis and therapy of neuroblastoma.
Mitochondria, Amyloid β, and Alzheimer's Disease

Hypometabolism is a hallmark of Alzheimer's disease (AD) and implicates a mitochondrial role in the neuropathology associated with AD. Mitochondrial amyloid-beta (Aβ) accumulation precedes extracellular Aβ deposition. In addition to increasing oxidative stress, Aβ has been shown to directly inhibit mitochondrial enzymes. Inhibition of mitochondrial enzymes as a result of oxidative damage or Aβ interaction perpetuates oxidative stress and leads to a hypometabolic state. Additionally, Aβ has also been shown to interact with cyclophilin D, a component of the mitochondrial permeability transition pore, which may promote cell death. Therefore, ample evidence exists indicating that the mitochondrion plays a vital role in the pathophysiology observed in AD.
Effects of Physical Activity and Inactivity on Muscle Fatigue

The aim of this review was to examine the mechanisms by which physical activity and inactivity modify muscle fatigue. It is well known that acute or chronic increases in physical activity result in structural, metabolic, hormonal, neural, and molecular adaptations that increase the level of force or power that can be sustained by a muscle. These adaptations depend on the type, intensity, and volume of the exercise stimulus, but recent studies have highlighted the role of high intensity, short-duration exercise as a time-efficient method to achieve both anaerobic and aerobic/endurance type adaptations. The factors that determine the fatigue profile of a muscle during intense exercise include muscle fiber composition, neuromuscular characteristics, high energy metabolite stores, buffering capacity, ionic regulation, capillarization, and mitochondrial density. Muscle fiber-type transformation during exercise training is usually toward the intermediate type IIA at the expense of both type I and IIx myosin heavy-chain isoforms. High-intensity training results in increases of both glycolytic and oxidative enzymes, muscle capillarization, improved phosphocreatine resynthesis and regulation of K+, H+, and lactate ions. Decreases of the habitual activity level due to injury or sedentary lifestyle result in partial or even compete reversal of the adaptations due to previous training, manifested by reductions in fiber cross-sectional area, decreased oxidative capacity, and capillarization. Complete immobilization due to injury results in markedly decreased force output and fatigue resistance. Muscle unloading reduces electromyographic activity and causes muscle atrophy and significant decreases in capillarization and oxidative enzymes activity. The last part of the review discusses the beneficial effects of intermittent high-intensity exercise training in patients with different health conditions to demonstrate the powerful effect of exercise on health and well being.
Rules and Natural Language Pattern in Extracting Quranic Knowledge

The extraction of Quranic knowledge is a challenging task since the Quran is different from human literature. The unique arrangement of its texts has made the task of directly accessing its meaning, which is rich in its linguistics and multi-layered meanings, difficult if done without the use of other resources such as the Hadith. Hence, this paper describes the extraction of the first layer and the use of natural language pattern in extracting the knowledge of Quranic English translation texts using natural language processing techniques. Evaluation is performed using the true positive, false positive and false negative metrics and encouraging results have been obtained.
Does “putting on your thinking cap” reduce myside bias in evaluation of scientific evidence?

Abstract The desire to maintain current beliefs can lead individuals to evaluate contrary evidence more critically than consistent evidence. We test whether priming individuals’ scientific reasoning skills reduces this often-observed myside bias, when people evaluate scientific evidence about which they have prior positions. We conducted three experiments in which participants read a news-style article about a study that either supported or opposed their attitudes regarding the Affordable Care Act. We manipulated whether participants completed a test posing scientific reasoning problems before or after reading the article and evaluating the evidence that it reported. Consistent with previous research, we found that participants were biased in favor of evidence consistent with their prior attitudes regarding the Affordable Care Act. Priming individuals’ scientific reasoning skills reduced myside bias only when accompanied by direct instructions to apply those skills to the task at hand. We discuss the processes contributing to biased evaluation of scientific evidence.
Parametric study of probe positioning errors in articulated spherical near-field test systems for mm-wave applications

This paper describes an articulated arm spherical near-field scanner design which transports a probe over a hyper-hemispherical surface that surrounds a stationary test antenna. Surface profile data collected with a laser tracker is presented and a parametric study performed to investigate the viability of testing at mm-wave frequencies is described. Parameters such as probe radial distance, and angular positioning are investigated to assess to what extent spherical near-field testing can be performed using this structure.
Volume-sensitive K transport in human erythrocytes

Studies have been carried out on human erythrocytes to examine the alterations of K transport induced by swelling or shrinking the cells by osmotic and isosmotic methods. Hypotonic swelling of erythrocytes (relative cell volume, 1.20) resulted in a striking, four- to fivefold augmentation in the ouabain-resistant K influx over the value obtained at a normal cell volume. Shrinking the cells in hypertonic media resulted in a small but statistically significant reduction in K influx. Three different methods of varying cell volume gave similar results. These include the addition of sucrose and of NaCl to hypotonic media and the isosmotic (nystatin) method. The major fraction of the K influx in swollen cells is specific in its requirement for Cl or Br and is not supported by thiocyanate, iodide, nitrate, methylsulfate, or acetate. Bumetanide (0.1 mM), MK-196 (0.2 mM), and piretanide (1 mM) are poorly effective in suppressing K uptake in swollen cells, but at higher concentrations, bumetanide (1 mM) inhibits 80% of the Cl- dependent K influx in swollen cells. The bumetanide concentration required to inhibit 50% of the Cl-dependent K influx is 0.17 mM. The volume-sensitive K influx is independent of both extracellular and intracellular Na, so that the (Na + K + 2Cl) cotransport pathway is not a likely mediator of the volume-sensitive K transport. A variety of inhibitors of the Ca-activated K channel are ineffective in suppressing swelling-induced K influx. Like K uptake, the efflux of K is also enhanced by cell swelling. Swelling-activated K efflux is Cl dependent, is independent of extracellular and intracellular Na, and is observed with both hypotonic and isosmotic methods of cell swelling. The activation of K efflux by cell swelling is observed in K-free media, which suggests that the volume-sensitive K transport pathway is capable of net K efflux. The addition of external K to hypotonic media resulted in an increase in K efflux compared with the efflux in K-free media, and this increase was probably due to K/K exchange. Thus, hypotonic or isosmotic swelling of human erythrocytes results in the activation of a ouabain-resistant, Cl-dependent, Na-independent transport pathway that is capable of mediating both net K efflux and K/K exchange.
PATHWISE COORDINATE OPTIMIZATION

We consider “one-at-a-time” coordinate-wise descent algorithms for a class of convex optimization problems. An algorithm of this kind has been proposed for the L1-penalized regression (lasso) in the literature, but it seems to have been largely ignored. Indeed, it seems that coordinate-wise algorithms are not often used in convex optimization. We show that this algorithm is very competitive with the well-known LARS (or homotopy) procedure in large lasso problems, and that it can be applied to related methods such as the garotte and elastic net. It turns out that coordinate-wise descent does not work in the “fused lasso,” however, so we derive a generalized algorithm that yields the solution in much less time that a standard convex optimizer. Finally, we generalize the procedure to the two-dimensional fused lasso, and demonstrate its performance on some image smoothing problems. 1. Introduction. In this paper we consider statistical models that lead to convex optimization problems with inequality constraints. Typically, the optimization for these problems is carried out using a standard quadratic programming algorithm. The purpose of this paper is to explore “one-at-a-time” coordinate-wise descent algorithms for these problems. The equivalent of a coordinate descent algorithm has been proposed for the L1-penalized regression (lasso) in the literature, but it is not commonly used. Moreover, coordinate-wise algorithms seem too simple, and they are not often used in convex optimization, perhaps because they only work in specialized problems. We ourselves never appreciated the value of coordinate descent methods for convex statistical problems before working on this paper. In this paper we show that coordinate descent is very competitive with the wellknown LARS (or homotopy) procedure in large lasso problems, can deliver a path of solutions efficiently, and can be applied to many other convex statistical problems such as the garotte and elastic net. We then go on to explore a nonseparable problem in which coordinate-wise descent does not work—the “fused lasso. ” We derive a generalized algorithm that yields the solution in much less time that a standard convex optimizer. Finally, we generalize the procedure to
Involvement of myogenic regulator factors during fusion in cell line C 2 C 12

The myogenic factors, MyoD, myogenin, Myf5 and MRF4, can activate skeletal muscle differentiation when overexpressed in non-muscular cells. Gene targeting experiments have provided much insight into the in vivo functions of MRF and have defined two functional groups of MRFs. MyoD and Myf5 may be necessary for myoblast determination while myogenin and MRF4 may be required later during differentiation. However, the specific role of these myogenic factors has not been clearly defined during one important stage of myogenesis: the fusion of myoblasts. Using cultured C2C12 mouse muscular cells, the time-course of these proteins was analyzed and a distinct expression pattern in fusing cells was revealed. In an attempt to clarify the role of each of these regulators during myoblast fusion, an antisense strategy using oligonucleotides with phosphorothioate backbone modification was adoped. The results showed that the inhibition of myogenin and Myf5 activity is capable of significantly preventing fusion. Furthermore, the inhibition of MyoD can wholly arrest the engaged fusion process in spite of high endogenous expression of both myogenin and Myf5. Consequently, each MRF seems to have, at this defined step of myogenesis, a specific set of functions that can not be substituted for by the others and therefore may regulate a distinct subset of muscle-specific genes at the onset of fusion.
Identifying ECUs Using Inimitable Characteristics of Signals in Controller Area Networks

As the functions of vehicles are more computerized for the safety and convenience of drivers, attack surfaces of vehicle are accordingly increasing. Many attack results have shown that an attacker could intentionally control vehicles. Most of them exploit the vulnerability that controller area network (CAN) protocol, a de-facto standard for the in-vehicle networks, does not support message origin authentication. Although a number of methods to resolve this security vulnerability have been suggested, they have their each limitation to be applied into the current system. They have required either the modification of the CAN standard or dramatical communication load increase, which is infeasible in practice. In this paper, we propose a novel identification method, which works in the physical layer of the in-vehicle CAN network. Our method identifies electronic control units (ECUs) using inimitable characteristics of electrical CAN signals enabling detection of a malicious ECU. Unlike previous attempts to address the security problem in the in-vehicle CAN network, our method works by simply adding a monitoring unit to the existing network, making it deployable in current systems and compliant with required CAN standards. Our experimental results show that our method is able to correctly identify ECUs. In case of misclassfication rate for ECU idnetification, our method yields 0.36% in average which is approximate four times lower than the method proposed by P.-S. Murvay et al. This paper is also the first to identify potential attack models that systems should be able to detect.
Priority-based technique for the best-effort delivery of stored video

In this paper, we introduce a priority-based technique for the delivery of compressed prerecorded video streams across best-effort networks. This technique uses a multi-level priority queue in conjunction with a delivery window to help smooth the video frame rate delivered to the end user while allowing it to easily adapt to changing network conditions. Compared with current approaches, our priority-based approach has several advantages. First, it acts more globally by ensuring that a minimum frame rate for the window interval has been delivered before sending enhancement layers. Second, this approach is much simpler to implement than other frame smoothing algorithms that have been presented for the delivery of stored video across best- effort networks. Finally, this approach is directly applicable for the shaping of MPEG-based video encodings with frame dependencies.
The Effect of Using an Educational Poster on Elementary School Health Teachers’ Knowledge of Emergency Management of Traumatic Dental Injuries

Objective: The purpose of this study was to evaluate the effect of an educational poster on elementary school health teachers’ knowledge about emergency management of traumatic dental injuries. Materials and Methods: Before poster presentation, a questionnaire was distributed to 40 health teachers (30 in the study group and 10 in the control group). One month after poster distribution, the subjects were re-evaluated in both groups using the same questionnaire. Results: The percentage of participating health teachers who answered the questions correctly after poster distribution regarding crown fracture was 93.3% in the test group vs. 60% in controls; for management of luxation and avulsion, the percentages for cases and controls were 63.3% vs. 40% and 100% vs. 60%, respectively. One month after distribution of the educational poster, rate of correct responses increased in management of crown fracture, luxation, and avulsion in the test group, but there was no improvement in controls (P<0.001). Conclusion: Use of an educational poster enhanced the knowledge of health teachers. Use of posters is an effective way to inform teachers of the management of traumatic dental injuries.
A Comparison of Rehabilitation Methods After Arthroscopic Rotator Cuff Repair

Context: Despite the significant attention directed toward optimizing arthroscopic rotator cuff repair, there has been less focus on rehabilitation after rotator cuff repair surgery. Objective: To determine the effect of different rehabilitation protocols on clinical outcomes by comparing early versus late mobilization approaches and continuous passive mobilization (CPM) versus manual therapy after arthroscopic rotator cuff repair. Data Sources: PubMed was searched for relevant articles using the keywords rotator cuff, rotator, cuff, tears, lacerations, and rehabilitation to identify articles published from January 1980 to March 2014. Study Selection: Inclusion criteria consisted of articles of level 1 or 2 evidence, written in the English language, and with reported outcomes for early versus late mobilization or rehabilitation with CPM versus manual therapy after primary arthroscopic rotator cuff repair. Exclusion criteria consisted of articles of level 3, 4, or 5 evidence, non-English language, and those with significantly different demographic variables between study groups. Included studies were evaluated with the Consolidated Standards of Reporting Trials criteria. Study Design: Systematic review. Level of Evidence: Level 2. Data Extraction: Level of evidence, study type, number of patients enrolled, number of patients at final follow-up, length of follow-up, age, sex, rotator cuff tear size, surgical technique, and concomitant operative procedures were extracted from included articles. Postoperative data included clinical outcome scores, visual analog score for pain, shoulder range of motion, strength, and rotator cuff retear rates. Results: A total of 7 studies met all criteria and were included in the final analysis. Five studies compared early and late mobilization. Two studies compared CPM and manual therapy. Conclusion: In general, current data do not definitively demonstrate a significant difference between postoperative rotator cuff rehabilitation protocols that stress different timing of mobilization and use of CPM.
A Novel Positioning Algorithm in Wireless Sensor Networks Based on Indoor Connective Information

Localization information of individual nodes is crucial for many advanced functions including routing, querying in wireless sensor networks. Most of the existing localization algorithms in wireless sensor networks are designed for outdoor environment and few of them can get a reasonable localization precision in indoor environment. This paper presents a novel indoor localization scheme which uses the spatial connective information to filter distorted messages, so as to improve the positioning precision. We establish an indoor positioning dome system, make performance comparison with other schemes and fully prove the advantages of our proposed indoor scheme.
Home language, school language and children's literacy attainments: A systematic review of evidence from low‐ and middle‐income countries

The general consensus in the field is that when the home language is different from the language of instruction in school then children’s literacy attainments could slow down. In this 26-year review of the literature on children’s literacy attainments in lowto middle-income countries, 40 correlational, ethnographic and intervention studies provide the data. We test the ‘home language advantage’ hypothesis where we expect children who speak the same language at home and school to show better literacy learning. We also examine other attributes in the home language and literacy environment (HLLE). Among the multivariate studies, trends differ across countries, age and grade levels, and child measures. Rather than a universal home language advantage, the evidence shows that home language advantage is context-sensitive. The correlational and ethnographic evidence point to a multiple risk factors model of home and school language disconnection; and the ethnographic and intervention studies provide complementary evidence of both feelings of unease, disempowerment and wish to help among family members, and increased confidence following guided support. Possible underlying mechanisms are examined through parallel synthesis of evidence from multiple research methods on three HLLE dimensions—books-at-home, home tutoring and adult literacy practices. The data partially corroborate findings from high-income countries (e.g. home environments impact literacy development, responsive parenting is present across families) but also bring focus on context-specific realities. Neither low-income nor low-print environments are uniform constraints because communities differ and some homes use available resources more efficiently than others.
The relative contribution of layers of the Social Ecological Model to childhood obesity

Abstract Objective The Social Ecological Model (SEM) has been used to describe the aetiology of childhood obesity and to develop a framework for prevention. The current paper applies the SEM to data collected at multiple levels, representing different layers of the SEM, and examines the unique and relative contribution of each layer to children’s weight status. Design Cross-sectional survey of randomly selected households with children living in low-income diverse communities. Setting A telephone survey conducted in 2009–2010 collected information on parental perceptions of their neighbourhoods, and household, parent and child demographic characteristics. Parents provided measured height and weight data for their children. Geocoded data were used to calculate proximity of a child’s residence to food and physical activity outlets. Subjects Analysis based on 560 children whose parents participated in the survey and provided measured heights and weights. Results Multiple logistic regression models were estimated to determine the joint contribution of elements within each layer of the SEM as well as the relative contribution of each layer. Layers of the SEM representing parental perceptions of their neighbourhoods, parent demographics and neighbourhood characteristics made the strongest contributions to predicting whether a child was overweight or obese. Layers of the SEM representing food and physical activity environments made smaller, but still significant, contributions to predicting children’s weight status. Conclusions The approach used herein supports using the SEM for predicting child weight status and uncovers some of the most promising domains and strategies for childhood obesity prevention that can be used for designing interventions.
Towards defining media socialization as a basis for digital society

The present article analyzes media socialization as one of the key factors for the formation of a digital society, involving the participation of individuals and communities. The objectives of the article are: to justify the impact of family educational institutions and community environments as contributing to the development of digital skills, attitudes and media literacy. The analysis is based on three rounds of European Social Survey (ESS) - national representative surveys carried out in 2006, 2009, 2012/2013, and 2012/2013 that analyzes the participation of the Bulgarian population in the social and political life of the country. In addition, the results of empirical studies conducted at the South-West University “N. Rilski”, Blagoevgrad, Bulgaria for the period 2003-2017 are presented. The main conclusion of the article is that media socialization, based on media ecology information is important, because people acquire a clearer perspective as to how to evaluate a situation and to the increased opportunities for personal realization and development.