Miracle-dz/UniFAR-FTUs huggingface dataset:
ASSESSMENT OF MECHANICAL PROPERTIES OF OFFROAD VEHICLE TIRE: COUPONS TESTING AND FE MODEL DEVELOPMENT

In this paper the subsequent stages of tire rubber coupons mechanical properties experimental assessment are presented. Experimental uniaxial tension and compression tests were carried out on the strength testing machine with the assistance of high'speed camera and special software for strain measurements. Obtained stress'strain curves were applied into the chosen Mooney'Rivlin constitu' tive rubber material model in order to estimate necessary material constants. Simultaneously, the numerical off'road vehicle tire model was developed. Geometry of the tire and rim was achieved using a 3D scanning method. Moreover, with the assistance of microscope and X'ray device the tire cords pattern was verified, which in the next stages was implemented into the FE model. Consequently, tire radial deflection test was simulated in order to validate evaluated material constants and proposed concept of the numerical tire modelling. Obtained results were compared with the actual deflection test data included in technical documentation of the tire.
Stabilization and mobility of the head and trunk in wild monkeys during terrestrial and flat-surface walks and gallops

SUMMARY This study investigated the patterns of rotational mobility (>20°) and stability (≤20°) of the head and trunk in wild Indian monkeys during natural locomotion on the ground and on the flat-topped surfaces of walls. Adult hanuman langurs (Semnopithecus entellus) and bonnet macaques (Macaca radiata) of either gender were cine filmed in lateral view. Whole-body horizontal linear displacement, head and trunk pitch displacement relative to space (earth horizontal), and vertical head displacement were measured from the cine films. Head-to-trunk pitch angle was calculated from the head-to-space and trunk-to-space measurements. Locomotor velocities, cycle durations, angular segmental velocities, mean segmental positions and mean peak frequencies of vertical and angular head displacements were then calculated from the displacement data. Yaw rotations were observed qualitatively. During quadrupedal walks by both species, the head was free to rotate in the pitch and yaw planes on a stabilized trunk. By contrast, during quadrupedal gallops by both species, the trunk pitched on a stabilized head. During both gaits in both species, head and trunk pitch rotations were symmetrical about comparable mean positions in both gaits, with mean head position aligning the horizontal semicircular canals near earth horizontal. Head pitch direction countered head vertical displacement direction to varying degrees during walks and only intermittently during gallops, providing evidence that correctional head pitch rotations are not essential for gaze stabilization. Head-to-space pitch velocities were below 350 deg. s–1, the threshold above which, at least among humans, the vestibulo-ocular reflex (VOR) becomes saturated. Mean peak frequencies of vertical translations and pitch rotations of the head ranged from 1 Hz to 2 Hz, a lower frequency range than that in which inertia is predicted to be the major stabilizer of the head in these species. Some variables, which were common to both walks and gallops in both species, are likely to reflect constraints in sensorimotor control. Other variables, which differed between the two gaits in both species, are likely to reflect kinematic differences, whereas variables that differed between the two species are attributed primarily to morphological and behavioural differences. It is concluded that either the head or the trunk can provide the nervous system with a reference frame for spatial orientation and that the segment providing that reference can change, depending upon the kinematic characteristics of the chosen gait.
Multitemporal repeat pass SAR interferometry of boreal forests

Multitemporal interferometric European Remote Sensing 1 and 2 satellite tandem pairs from a forest test site in Finland are examined in order to determine the stem volume retrieval accuracy. A form of multitemporal filtering is introduced to investigate what forest stands show a multitemporal consistency in coherence. It is found that a large stand size is a major factor to obtain accurate retrievals. The effect of heterogeneity of forest stands is also discussed. Based on the stands showing highest multitemporal consistency different models for scattering and coherence are compared. The interferometric water cloud model is chosen for stem volume retrieval. The variation of the model parameters with meteorological parameters is investigated and the results illustrate that the best imaging conditions are obtained for subzero temperatures and windy conditions. It is shown that for the 20 stands showing highest multitemporal consistency the stem volume can be retrieved with a relative error of 21%, deteriorating when the number of testing stands is increased, e.g., for 80 stands the error is 48%. For 37 large forest stands representing 48% of the investigated area the relative stem volume error is 26%. With experience from another site in Sweden we may conclude that the error level for a multitemporal interferometric synthetic aperture radar evaluation of stem volume for large forest stands (>2 ha) in a well managed and homogeneous boreal forest may be expected to be in the 15% to 25% range, deteriorating for small and heterogeneous stands and for images acquired under nonwinter conditions.
Diagnosis and treatment of traumatic pulmonary pseudocysts.

BACKGROUND Traumatic pulmonary pseudocysts (TPPs) are rare sequelae of blunt chest trauma. We present a retrospective review of TPPs observed in our hospital and discuss the diagnosis, treatment, and complications of these unusual lesions. METHODS Between 1991 and 1999, 11 TPPs were diagnosed in 10 patients. None of the lesions was detectable on the chest radiograph obtained on the day of injury. In contrast, computed tomographic scan of the chest always demonstrated the TPPs. RESULTS In nine cases, spontaneous healing of the lesions was observed. One patient with a large lesion of the left lower lobe developed significant endobronchial bleeding and underwent successful emergency lobectomy. CONCLUSION TPPs are often missed by chest radiography, particularly when it is obtained in the supine position, whereas computed tomographic scan allows the identification of these lesions in all cases. TPPs are self-limiting, benign lesions that usually require no specific therapy. Surgical treatment is indicated in rare instances and only when complications occur.
Analogical Learning in a Turn-Based Strategy Game

A key problem in playing strategy games is learning how to allocate resources effectively. This can be a difficult task for machine learning when the connections between actions and goal outputs are indirect and complex. We show how a combination of structural analogy, experimentation, and qualitative modeling can be used to improve performance in optimizing food production in a strategy game. Experimentation bootstraps a case library and drives variation, while analogical reasoning supports retrieval and transfer. A qualitative model serves as a partial domain theory to support adaptation and credit assignment. Together, these techniques can enable a system to learn the effects of its actions, the ranges of quantities, and to apply training in one city to other, structurally different cities. We describe experiments demonstrating this transfer of learning.
The Effect of the Systemic Antimycotics, Itraconazole and Fluconazole, on the Pharmacokinetics and Pharmacodynamics of Intravenous and Oral Midazolam

We studied the interaction of azole antimycotics with intravenous (IV) and oral midazolam using a cross-over design in 12 volunteers, who ingested placebo, itraconazole, or fluconazole for 6 days. A 7.5-mg dose of midazolam was ingested on the first day, 0.05 mg/kg was administered IV on the fourth day, and 7.5 mg orally on the sixth day. Itraconazole reduced the clearance of IV midazolam by 69% and fluconazole reduced the clearance of IV midazolam by 51% (P < 0.001). A single dose of itraconazole and fluconazole increased the area under the oral midazolam concentration-time curve [AUC(0-infinity)] 3.5-fold (P < 0.001) and the peak concentration two-fold (P < 0.05) compared to placebo. On the sixth day the AUC(0- infinity) of oral midazolam was almost seven times greater with itraconazole (P < 0.001) and 3.6 times greater with fluconazole (P < 0.001) than without the antimycotics. The psychomotor effects of midazolam were also profoundly increased (P < 0.001). The psychomotor tests demonstrated only a weak interaction between the antimycotics and IV midazolam. When bolus doses of midazolam are given for shorttime sedation, the effect of midazolam is not increased to a clinically significant degree by itraconazole and fluconazole, and it can be used in normal doses. However, the use of large doses of IV midazolam increases the risk of clinically significant interactions also after IV midazolam. Use of oral midazolam with itraconazole and fluconazole should be avoided. (Anesth Analg 1996;82:511-6)
A Framework for Research and Curriculum Development in Undergraduate Mathematics Educationjpeg

Over the past several years, a community of researchers has been using and re ning a particular framework for research and curriculum development in undergraduate mathematics education. The purpose of this paper is to share the results of this work with the mathematics education community at large by describing the current version of the framework and giving some examples of its application. Our framework utilizes qualitative methods for research and is based on a very speci c theoretical perspective that is being developed through attempts to understand the ideas of Piaget concerning reective abstraction and reconstruct them in the context of college level mathematics. Our approach has three components. It begins with an initial theoretical analysis of what it means to understand a concept and how that understanding can be constructed by the learner. This leads to the design of an instructional treatment that focuses directly on trying to get students to make the constructions called for by the analysis. Implementation of instruction leads to the gathering of data, which is then analyzed in the context of the theoretical perspective. The researchers cycle through the three components and re ne both the theory and the instructional treatments as needed. In this report the authors present detailed descriptions of each of these components. In our discussion of theoretical analyses, we describe certain mental constructions for learning mathematics, including actions, processes, objects, and schemas, and the relationships among these constructions. Under instructional treatment, we describe the components of the ACE teaching cycle (activities, class discussion, and exercises), cooperative learning and the use of a mathematical programming language. Finally, we describe the methodology used in data collection and analysis. The paper concludes with a discussion of issues raised in the use of this framework, followed by an extensive bibliography.
Monoclonal antibodies specific for subsets of epidermal keratins: Biochemical and immunocytochemical characterization—applications in pathology and cell culture

Keratin composition has been widely used as a biochemical marker of differentiation in normal epithelia, cell culture systems and tumours of epithelial tissues. We have been developing a model system for the study of human squamous epithelial cell differentiation, and among a panel of monoclonal antibodies we have generated for analysing this system are two antibodies recognizing subsets of epidermal keratins. The two antibodies, designated LICR‐LON‐16a and LICR‐LON‐29b, were raised to the human squamous carcinoma cell line LICR‐LON‐HN‐5, and we describe here their biochemical and immunocytochemical characterization. Antibody 16a reacts with only epidermal basal cells in normal human skin and shows specificity for the 45 and 46 kdalton keratins. Antibody 29b stains all living layers of the epidermis, and reacts with a broad range of ketain polypeptides, (45–56 kdaltons) in immunoblotting analyses. We have investigated the alterations of cellular staining that occur in chronic hyperproliferative skin diseases and carcinomas and compared this with the staining of multilayered cultures of normal keratinocytes and the HN‐5 cell line. We show that in squamous cell carcinomas and in HN‐5 cell xenografts 16a and 29b stain only the well‐differentiated cell types. Furthermore we found that the basal cell specificity of 16a was lost in all of the hyper‐proliferative skin lesions examined including psoriasis and eczema. This transition to suprabasal staining pattern was also seen in the cultures of normal keratinocytes and HN‐5 cells. We conclude that aberrant keratin synthesis or abnormal post‐translational processing of keratins associated with an increased rate of cell turnover could account for the altered expression of the epitope recognized by antibody 16a.
Involvement of Sensor Kinases in the Stress Tolerance Response of Streptococcus mutans

ABSTRACT The gram-positive bacterium Streptococcus mutans is the primary causative agent in the formation of dental caries in humans. The ability of S. mutans to adapt and to thrive in the hostile environment of the oral cavity suggests that this cariogenic pathogen is capable of sensing and responding to different environmental stimuli. This prompted us to investigate the role of two-component signal transduction systems (TCS), particularly the sensor kinases, in response to environmental stresses. Analysis of the annotated genome sequence of S. mutans indicates the presence of 13 putative TCS. Further bioinformatics analysis in our laboratory has identified an additional TCS in the genome of S. mutans. We verified the presence of the 14 sensor kinases by using PCR and Southern hybridization in 13 different S. mutans strains and found that not all of the sensor kinases are encoded by each strain. To determine the potential role of each TCS in the stress tolerance of S. mutans UA159, insertion mutations were introduced into the genes encoding the individual sensor kinases. We were successful in inactivating all of the sensor kinases, indicating that none of the TCS are essential for the viability of S. mutans. The mutant S. mutans strains were assessed for their ability to withstand various stresses, including osmotic, thermal, oxidative, and antibiotic stress, as well as the capacity to produce mutacin. We identified three sensor kinases, Smu486, Smu1128, and Smu1516, which play significant roles in stress tolerance of S. mutans strain UA159.
The Principled Design of Large-Scale Recursive Neural Network Architectures--DAG-RNNs and the Protein Structure Prediction Problem

We describe a general methodology for the design of large-scale recursive neural network architectures (DAG-RNNs) which comprises three fundamental steps: (1) representation of a given domain using suitable directed acyclic graphs (DAGs) to connect visible and hidden node variables; (2) parameterization of the relationship between each variable and its parent variables by feedforward neural networks; and (3) application of weight-sharing within appropriate subsets of DAG connections to capture stationarity and control model complexity. Here we use these principles to derive several specific classes of DAG-RNN architectures based on lattices, trees, and other structured graphs. These architectures can process a wide range of data structures with variable sizes and dimensions. While the overall resulting models remain probabilistic, the internal deterministic dynamics allows efficient propagation of information, as well as training by gradient descent, in order to tackle large-scale problems. These methods are used here to derive state-of-the-art predictors for protein structural features such as secondary structure (1D) and both fine- and coarse-grained contact maps (2D). Extensions, relationships to graphical models, and implications for the design of neural architectures are briefly discussed. The protein prediction servers are available over the Web at: www.igb. uci.edu/tools.htm .
10 years of BAWLing into affective and aesthetic processes in reading: what are the echoes?

Reading is not only “cold” information processing, but involves affective and aesthetic processes that go far beyond what current models of word recognition, sentence processing, or text comprehension can explain. To investigate such “hot” reading processes, standardized instruments that quantify both psycholinguistic and emotional variables at the sublexical, lexical, inter-, and supralexical levels (e.g., phonological iconicity, word valence, arousal-span, or passage suspense) are necessary. One such instrument, the Berlin Affective Word List (BAWL) has been used in over 50 published studies demonstrating effects of lexical emotional variables on all relevant processing levels (experiential, behavioral, neuronal). In this paper, we first present new data from several BAWL studies. Together, these studies examine various views on affective effects in reading arising from dimensional (e.g., valence) and discrete emotion features (e.g., happiness), or embodied cognition features like smelling. Second, we extend our investigation of the complex issue of affective word processing to words characterized by a mixture of affects. These words entail positive and negative valence, and/or features making them beautiful or ugly. Finally, we discuss tentative neurocognitive models of affective word processing in the light of the present results, raising new issues for future studies.
Orienting Attention to an Upcoming Tactile Event Involves a Spatially and Temporally Specific Modulation of Sensorimotor Alpha- and Beta-Band Oscillations

Our perception is facilitated if we know where and when a sensory stimulus will occur. This phenomenon is accounted for by spatial and temporal orienting of attention. Whereas spatial orienting of attention has repeatedly been shown to involve spatially specific modulations of ongoing oscillations within sensory cortex, it is not clear to what extent anticipatory modulations of ongoing oscillations are involved in temporal orienting of attention. To address this, we recorded magnetoencephalography while human participants performed a tactile discrimination task. We cued participants to the left or the right hand, after which a tactile stimulus was presented at one of several fixed temporal delays. We thus assessed whether and how ongoing sensorimotor oscillations are modulated during tactile anticipation. We provide evidence for three phenomena. First, orienting to an upcoming tactile event involves a spatially specific contralateral suppression of alpha- and beta-band oscillations within sensorimotor cortex. Second, this modulation is deployed with temporal specificity, and this is more pronounced for beta-band compared with alpha-band oscillations. Third, the contralateral suppression of beta-band oscillations is associated with faster responses to subsequently presented tactile stimuli. Control measures showed that these results cannot be explained by motor planning or execution. We conclude that the modulation of ongoing oscillations within sensory cortex reflects a unifying mechanism underlying both spatial and temporal orienting of attention.
Microbubbles Enhance the Antitumor Effects of Sinoporphyrin Sodium Mediated Sonodynamic Therapy both In Vitro and In Vivo

Objectives: To evaluate the anti-cancer effect of sonodynamic therapy combined with microbubbles both in vitro and in vivo. Methods: Cell viability was measured by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide and guava viacount assays. Annexin V-FITC/PI staining was adopted to analyze cell apoptosis rate. FD500 uptake assay was performed to assess cell membrane permeability changes. Tumor weight, mice weight and the visual image of tumor size were used to reflect the anti-tumor effect of this combined method. Histological change of tumor tissue after different treatments was measured through hematoxylin and eosin (H&E) staining. Results: Microbubbles can significantly enhance the cytotoxicity and necrocytosis rate induced by SDT treatment. Increased cell membrane permeability and more uptake of DVDMS were founded in SDT combined with microbubbles group. For in vivo experiments, SDT with microbubbles can significantly reduce tumor weight and size with pimping difference of mice weight compare with other treatment groups. In addition, microbubbles notably improved tumor tissue destruction caused by ultrasound and SDT treatment. Conclusion: The results suggest that microbubbles can markedly improve the anti-cancer effect of DVDMS mediate sonodynamic therapy both in vitro and in vivo.
Starvation‐induced changes in transport of ketone bodies across the blood‐brain barrier

The permeability of the blood brain barrier (BBB) to β‐hydroxybutyrate (β‐HB) was computed in fed and starved (five days) rats by the simultaneous measurement of cerebral blood flow (diffusible indicator method‐123I‐iodoantipyrine) and brain uptake of 14C‐β‐HB (relative to a 3H2O reference). The results from the present study demonstrate that the movement of β‐HB across the BBB in rat is by a carrier‐mediated process. During starvation, total movement (carrier‐mediated and diffusionary) of this ketone body into brain was observed to be enhanced because of an increase in the diffusionary loss across the cerebral capillary. The calculated transport kinetics also suggest that the β‐HB molecule has a greater affinity for the transport (mediator) protein during starvation, although the maximal rate of uptake by brain due to a carrier processes mediated Vmax is decreased either because there is a smaller quantity of the mediating molecule or because there is trans inhibition by a high cellular concentration of β‐HB or some analog.
Network topology: patterns and mechanisms in plant-herbivore and host-parasitoid food webs.

1. Biological communities are organized in complex interaction networks such as food webs, which topology appears to be non-random. Gradients, compartments, nested subsets and even combinations of these structures have been shown in bipartite networks. However, in most studies only one pattern is tested against randomness and mechanistic hypotheses are generally lacking. 2. Here we examined the topology of regional, coexisting plant-herbivore and host-parasitoid food webs to discriminate between the mentioned network patterns. We also evaluated the role of species body size, local abundance, regional frequency and phylogeny as determinants of network topology. 3. We found both food webs to be compartmented, with interaction range boundaries imposed by host phylogeny. Species degree within compartments was mostly related to their regional frequency and local abundance. Only one compartment showed an internal nested structure in the distribution of interactions between species, but species position within this compartment was unrelated to species size or abundance. 4. These results suggest that compartmentalization may be more common than previously considered, and that network structure is a result of multiple, hierarchical, non-exclusive processes.
The Only Game in Town: Stock-Price Consequences of Local Bias

Theory suggests that, in the presence of local bias, the price of a stock should be decreasing in the ratio of the aggregate book value of firms in its region to the aggregate risk tolerance of investors in its region. We test this proposition using data on U.S. Census regions and states, and find clear-cut support for it. Most of the variation in the ratio of interest comes from differences across regions in aggregate book value per capita. Regions with low population density--e.g., the Deep South--are home to relatively few firms per capita, which leads to higher stock prices via an "only-game-in-town" effect. This effect is especially pronounced for smaller, less visible firms, where the impact of location on stock prices is roughly 12 percent.