Miracle-dz/UniFAR-FTUs huggingface dataset:
Progress in Titanium Metal Powder Injection Molding

Metal powder injection molding is a shaping technology that has achieved solid scientific underpinnings. It is from this science base that recent progress has occurred in titanium powder injection molding. Much of the progress awaited development of the required particles with specific characteristics of particle size, particle shape, and purity. The production of titanium components by injection molding is stabilized by a good understanding of how each process variable impacts density and impurity level. As summarized here, recent research has isolated the four critical success factors in titanium metal powder injection molding (Ti-MIM) that must be simultaneously satisfied—density, purity, alloying, and microstructure. The critical role of density and impurities, and the inability to remove impurities with sintering, compels attention to starting Ti-MIM with high quality alloy powders. This article addresses the four critical success factors to rationalize Ti-MIM processing conditions to the requirements for demanding applications in aerospace and medical fields. Based on extensive research, a baseline process is identified and reported here with attention to linking mechanical properties to the four critical success factors.
EXPERIMENTAL INVESTIGATION OF THE CONVECTIVE HEAT TRANSFER IN A SPIRALLY COILED CORRUGATED TUBE WITH RADIANT HEATING

The Archimedean spiral coil made of a transversely corrugated tube was exposed to radiant heating in order to represent a heat absorber of the parabolic dish solar concentrator. The main advantage of the considered innovative design solution is a coupling effect of the two passive methods for heat transfer enhancement - coiling of the flow channel and changes in surface roughness. The curvature ratio of the spiral coil varies from 0.029 to 0.234, while water and a mixture of propylene glycol and water are used as heat transfer fluids. The unique focus of this study is on specific boundary conditions since the heat flux upon the tube external surfaces varies not only in the circumferential direction, but in the axial direction as well. Instrumentation of the laboratory model of the heat absorber mounted in the radiation field includes measurement of inlet fluid flow rate, pressure drop, inlet and outlet fluid temperature and 35 type K thermocouples welded to the coil surface. A thermal analysis of the experimentally obtained data implies taking into consideration the externally applied radiation field, convective and radiative heat losses, conduction through the tube wall and convection to the internal fluid. The experimental results have shown significant enhancement of the heat transfer rate compared to spirally coiled smooth tubes, up to 240% in the turbulent flow regime.
Neuromyelitis optica spectrum disorders: An update

Recent advances in the understanding of neuromyelitis optica spectrum of disorders (NMOSD) have expanded. Diagnostic criteria have changed over the years. The clinical spectrum of disease manifestations are now understood to include sites outside the spinal cord and optic nerve. A variety of autoimmune diseases may coexist with this disorder. Non neurological manifestations have been recently reported. Novel biomarkers other than aquoporin 4 Immunoglobulin G (anti AQP4-IgG) have been discovered which may have clinical relevance. In particul myelin associated oligoglycoprotein antibody (MOG-Ab) associated NMOSD may be relatively benign. This update describes some of these new findings highlighting the clinical manifestations, biomarkers associated with the disease and magnetic resonance imaging characteristics of brain and spinal cord.
An exponential lower bound for homogeneous depth four arithmetic circuits with bounded bottom fanin

Agrawal and Vinay [AV08] have recently shown that an exponential lower bound for depth four homogeneous circuits with bottom layer of × gates having sublinear fanin translates to an exponential lower bound for a general arithmetic circuit computing the permanent. Motivated by this, we examine the complexity of computing the permanent and determinant via homogeneous depth four circuits with bounded bottom fanin. We show here that any homogeneous depth four arithmetic circuit with bounded bottom fanin computing the permanent (or the determinant) must be of exponential size.
Macrophage Specific Caspase-1/11 Deficiency Protects against Cholesterol Crystallization and Hepatic Inflammation in Hyperlipidemic Mice

Background & Aims While non-alcoholic steatohepatitis (NASH) is characterized by hepatic steatosis combined with inflammation, the mechanisms triggering hepatic inflammation are unknown. In Ldlr-/- mice, we have previously shown that lysosomal cholesterol accumulation in Kupffer cells (KCs) correlates with hepatic inflammation and cholesterol crystallization. Previously, cholesterol crystals have been shown to induce the activation of inflammasomes. Inflammasomes are protein complexes that induce the processing and release of pro-inflammatory cytokines IL-1b and IL-18 via caspase-1 activation. Whereas caspase-1 activation is independent of caspase-11 in the canonical pathway of inflammasome activation, caspase-11 was found to trigger caspase-1-dependent IL-1b and IL-18 in response to non-canonical inflammasome activators. So far, it has not been investigated whether inflammasome activation stimulates the formation of cholesterol crystals. We hypothesized that inflammasome activation in KCs stimulates cholesterol crystallization, thereby leading to hepatic inflammation. Methods Ldlr -/- mice were transplanted (tp) with wild-type (Wt) or caspase-1/11-/- (dKO) bone marrow and fed either regular chow or a high-fat, high-cholesterol (HFC) diet for 12 weeks. In vitro, bone marrow derived macrophages (BMDM) from wt or caspase-1/11-/- mice were incubated with oxLDL for 24h and autophagy was assessed. Results In line with our hypothesis, caspase-1/11-/--tp mice had less severe hepatic inflammation than Wt-tp animals, as evident from liver histology and gene expression analysis in isolated KCs. Mechanistically, KCs from caspase-1/11-/--tp mice showed less cholesterol crystals, enhanced cholesterol efflux and increased autophagy. In wt BMDM, oxLDL incubation led to disturbed autophagy activity whereas BMDM from caspase-1/11-/- mice had normal autophagy activity. Conclusion Altogether, these data suggest a vicious cycle whereby disturbed autophagy and decreased cholesterol efflux leads to newly formed cholesterol crystals and thereby maintain hepatic inflammation during NASH by further activating the inflammasome.
MazF-induced Growth Inhibition and Persister Generation in Escherichia coli *

Background: MazEF is a chromosomally encoded bacterial toxin-antitoxin system whose cellular role is controversial. Results: Expression of chromosomal MazF inhibits cell killing by multiple antibiotics in a Lon and ClpP dependent manner. Conclusion: MazF is involved in reversible growth inhibition and bacterial drug tolerance. Significance: Inactive, active-site toxin mutants yield functional insights by selectively activating the corresponding WT toxin in vivo. Toxin-antitoxin systems are ubiquitous in nature and present on the chromosomes of both bacteria and archaea. MazEF is a type II toxin-antitoxin system present on the chromosome of Escherichia coli and other bacteria. Whether MazEF is involved in programmed cell death or reversible growth inhibition and bacterial persistence is a matter of debate. In the present work the role of MazF in bacterial physiology was studied by using an inactive, active-site mutant of MazF, E24A, to activate WT MazF expression from its own promoter. The ectopic expression of E24A MazF in a strain containing WT mazEF resulted in reversible growth arrest. Normal growth resumed on inhibiting the expression of E24A MazF. MazF-mediated growth arrest resulted in an increase in survival of bacterial cells during antibiotic stress. This was studied by activation of mazEF either by overexpression of an inactive, active-site mutant or pre-exposure to a sublethal dose of antibiotic. The MazF-mediated persistence phenotype was found to be independent of RecA and dependent on the presence of the ClpP and Lon proteases. This study confirms the role of MazEF in reversible growth inhibition and persistence.
Effect of Intradiscal Monopolar Pulsed Radiofrequency on Chronic Discogenic Back Pain Diagnosed by Pressure-Controlled Provocative Discography: A One Year Prospective Study

Objective To investigate the efficacy and safety of percutaneous intradiscal monopolar pulsed radiofrequency (PRF) in patients with chronic disabling discogenic back pain. Method Twenty-six subjects (7 males; mean age 43.2 years) with chronic back pain refractory to active rehabilitative management were recruited. All subjects underwent MRI for evaluation of Modic changes, and monopolar PRF (20 min at 60 V) at the center of target lumbar intervertebral disc confirmed by pressure-controlled provocative discography. Clinical outcomes were measured by the visual analogue scale (VAS), Oswestry disability index (ODI), and sitting tolerance time (ST) for 12 months after treatment. Successful clinical outcome was described as a minimum of 2 point reduction in VAS compared with the baseline at each follow-up period. Results The mean VAS for low back pain reduced significantly from 6.4±1.1 at pre-treatment to 4.4±1.9 at 12 months (p<0.05). The mean ODI score was 47.3±15.4 points at pre-treatment and 36.7±19.5 at 12 months (p<0.001). The ST was 27.8±20.4 minutes at pre-treatment and 71.5±42.2 at 12 months (p<0.001). However, successful clinical outcome was achieved at 58%, 50%, and 42%, measured at 3, 6, and 12 months post-treatment. There were no significant relationship between the clinical outcome and Modic changes; no adverse events were recorded. Conclusion The results demonstrated that the application of intradiscal monopolar PRF might be relatively effective but limited; successful intervention for chronic refractory discogenic back pain is needed. To achieve the optimal outcome through intradiscal PRF, we suggested further studies about stimulation duration, mode, and intensity of PRF.
Regulated motion of glycoproteins revealed by direct visualization of a single cargo in the endoplasmic reticulum

The quality of cargo proteins in the endoplasmic reticulum (ER) is affected by their motion during folding. To understand how the diffusion of secretory cargo proteins is regulated in the ER, we directly analyze the motion of a single cargo molecule using fluorescence imaging/fluctuation analyses. We find that the addition of two N-glycans onto the cargo dramatically alters their diffusion by transient binding to membrane components that are confined by hyperosmolarity. Via simultaneous observation of a single cargo and ER exit sites (ERESs), we could exclude ERESs as the binding sites. Remarkably, actin cytoskeleton was required for the transient binding. These results provide a molecular basis for hypertonicity-induced immobilization of cargo, which is dependent on glycosylation at multiple sites but not the completion of proper folding. We propose that diffusion of secretory glycoproteins in the ER lumen is controlled from the cytoplasm to reduce the chances of aggregation.
Trichinellosis acquired in the United Kingdom

An outbreak of trichinellosis that occurred in the United Kingdom is described. Members of four households consumed pork salami from northern Serbia, the Federal Republic of Yugoslavia. Eight cases of trichinellosis occurred. Clinical and laboratory features of the cases were typical with myalgia (7 cases), fever (6), headache (5), periorbital oedema (4), non-specific ST/T wave changes on electrocardiogram (3), Trichinella antibodies (6), eosinophilia (7) and raised serum creatine kinase (3). All recovered. Trichinella larvae were detected in the salami. During pre-travel counselling, travellers should be advised about possible risk from cured pork products which have been produced locally in Trichinella endemic areas.
Planck 2013 results. XXVII. Doppler boosting of the CMB: Eppur si muove

Our velocity relative to the rest frame of the cosmic microwave background (CMB) generates a dipole temperature anisotropy on the sky which has been well measured for more than 30 years, and has an accepted amplitude of v=c = 1:23 10 3 , or v = 369 km s 1 . In addition to this signal generated by Doppler boosting of the CMB monopole, our motion also modulates and aberrates the CMB temperature fluctuations (as well as every other source of radiation at cosmological distances). This is an order 10 3 e ect applied to fluctuations which are already one part in roughly 10 5 , so it is quite small. Nevertheless, it becomes detectable with the all-sky coverage, high angular resolution, and low noise levels of the Planck satellite. Here we report a first measurement of this velocity signature using the aberration and modulation e ects on the CMB temperature anisotropies, finding a component in the known dipole direction, (l; b) = (264 ; 48 ), of 384 km s 1 78 km s 1 (stat:) 115 km s 1 (syst:). This is a significant confirmation of the expected velocity.
Inactivation of protein‐phosphatase 2A causing hyperphosphorylation of autoantigenic paraprotein targets in MGUS/MM is due to an exchange of its regulatory subunits

Hyperphosphorylated paratarg‐7 (pP‐7) carrier state is the strongest molecularly defined risk factor for monoclonal gammopathy of undetermined significance (MGUS), multiple myeloma (MM) and Waldenstrom's macroglobulinemia (WM). pP‐7 is inherited as autosomal‐dominant trait and depending on the ethnic background is found in over one‐third of MGUS/MM patients. P‐7, which is the antigenic paraprotein target in these patients, is hyperphosphorylated at serine17. P‐7 hyperphosphorylation can be induced in wild‐type P‐7 (wtP‐7) carriers by PKCζ and reverted by protein‐phosphatase 2A (PP2A). Here we show that dephosphorylation of pP‐7 is defective in pP‐7 carriers due to inactivation of the PP2A by substitution of the regulatory B55δ subunit with B56γ3. In lymphoblastoid cell lines from pP‐7 carriers, transfection of recombinant B55δ or treatment with ceramide led to a partial reconstitution of PP2A activity and dephosphorylation of pP‐7 to wtP7. Similar results were observed with other previously reported autoantigenic paraproteins targets. In conclusion, the mechanisms responsible for the defective dephosphorylation and maintaining the hyperphosphorylated state of P‐7 and other autoantigenic paraprotein targets have been elucidated, facilitating the identification of the genetic basis underlying this phenomenon which is obviously common in the pathogenesis of MGUS/MM/WM and not restricted to pP‐7 cases.
Multi-Core, Main-Memory Joins: Sort vs. Hash Revisited

In this paper we experimentally study the performance of main-memory, parallel, multi-core join algorithms, focusing on sort-merge and (radix-)hash join. The relative performance of these two join approaches have been a topic of discussion for a long time. With the advent of modern multi-core architectures, it has been argued that sort-merge join is now a better choice than radix-hash join. This claim is justified based on the width of SIMD instructions (sort-merge outperforms radix-hash join once SIMD is sufficiently wide), and NUMA awareness (sort-merge is superior to hash join in NUMA architectures). We conduct extensive experiments on the original and optimized versions of these algorithms. The experiments show that, contrary to these claims, radix-hash join is still clearly superior, and sort-merge approaches to performance of radix only when very large amounts of data are involved. The paper also provides the fastest implementations of these algorithms, and covers many aspects of modern hardware architectures relevant not only for joins but for any parallel data processing operator.
Fingerprint liveness detection using local texture features

The problem of fingerprint liveness detection has received an increasing attention in the last decade, as attested by the organisation of three editions of an international competition, named LivDet, dedicated to this challenge. LivDet editions and other works in the literature showed that the performance of current fingerprint liveness detection algorithms is not good enough to allow empowering a fingerprint verification system with a module aimed to distinguish alive from fake fingerprint images. However, recent developments have shown that texture-based features can provide promising solutions to this problem. In this study, a novel fingerprint liveness descriptor named binarised statistical image features (BSIFs) is adopted. Similarly to local binary pattern and local phase quantisation-based representations, BSIF encodes the local fingerprint texture into a feature vector by using a set of filters that, unlike other methods, are learnt from natural images. Extensive experiments with over 40,000 live and fake fingerprint images show that the authors’ proposed method outperforms most of the state-of-the-art algorithms, allowing a step ahead to the real integration of fingerprint liveness detectors into verification systems.
LEXCONN: A French Lexicon of Discourse Connectives

With respect to discourse organization, the most basic way of signaling the speaker’s or writer’s intentions is to use explicit lexical markers: so-called discourse markers or discourse connectives. While a lexicon of discourse connectives associated with the relations they express can be very useful for researchers, especially in Natural Language Processing, few projects aim at collecting them exhaustively, and only in a small number of languages. We present LEXCONN, a French lexicon of 328 discourse connectives, collected with their syntactic categories and the discourse relations they convey, and the methodology followed to build this resource. The lexicon has been constructed manually, applying systematic connective and relation identification criteria, using the FRANTEXT corpus as empirical support. Each connective has been associated to a relation within the framework of Segmented Discourse Representation Theory. We make a case for a few refinements in the theory, based on cases where no existing relation seemed to match a connective’s usage.
Numerical study of ground state energy fluctuations in spin glasses

Using a stochastic algorithm introduced in a previous paper, we study the finite size volume corrections and the fluctuations of the ground state energy in the Sherrington-Kirkpatrick and the EdwardsAnderson models at zero temperature. The algorithm is based on a suitable annealing procedure coupled with a balanced greedy-reluctant strategy that drives the systems towards the deepest minimum of the energy function.
Development of a Chitosan-Based Biofoam: Application to the Processing of a Porous Ceramic Material

Developing biofoams constitutes a challenging issue for several applications. The present study focuses on the development of a chitosan-based biofoam. Solutions of chitosan in acetic acid were dried under vacuum to generate foams with high-order structures. Chitosan concentration influenced significantly the morphology of developed porosity and the organization of pores in the material. Physico-chemical characterizations were performed to investigate the effects of chitosan concentration on density and thermal conductivity of foams. Even if chitosan-based biofoams exhibit interesting insulating properties (typically around 0.06 W·m−1·K−1), it has been shown that their durabilities are limited when submitted to a wet media. So, a way of application consists to elaborate a ceramic material with open porosity from a slurry prepared with an organic solvent infiltrating the porous network of the foam.
Design, Testing, and Validation of a Simplified Control Scheme for a Novel Plug-In Hybrid Electric Vehicle Battery Cell Equalizer

In order to meet cost targets for hybrid electric (HEV), plug-in hybrid electric (PHEV), and all-electric vehicles (EV), an improvement in the battery life cycle and safety is essential. Recently, lithium batteries, in the form of lithium-ion, lithium-polymer, or lithium iron phosphate have been explored. Despite research initiatives, lithium-based batteries have not yet been able to meet steep energy demands, long lifetime, and low cost of vehicular propulsion applications. One practical approach to improve performance is to use power electronics intensive cell voltage equalizers, in conjunction with on-board energy storage devices. The purpose of this paper is to introduce a simplified control scheme, based on open-circuit voltage estimation, for a novel cell equalizer configuration, with the potential to fulfil expectations of the following: 1) low cost; 2) large currents; and 3) high efficiency. Issues, such as the limitations on maximum and minimum cell voltage, noise, and quantization errors, are explored. Finally, a comprehensive comparison between the theoretical test results and practical equalization test results is presented.
Randomized comparative efficacy and safety study of intermittent simvastatin versus fenofibrate in hemodialysis.

AIM Compare the safety and efficacy of intermittent fenofibrate versus simvastatin in chronic hemodialysis patients. PATIENTS & METHODS Sixty patients received either fenofibrate 100 mg or simvastatin 20 mg after their dialysis session (parallel study). The safety and efficacy of drugs on lipid profile, oxidized low-density lipoprotein (Ox-LDL), glutathione peroxidase and C-reactive protein were compared before and after 16-week treatment. RESULTS After treatment, significant increase in glutathione peroxidase, significant decrease in total cholesterol, triglycerides, low density lipoprotein (LDL) and ox-LDL (p < 0.05) and no significant changes in C-reactive protein (p > 0.05) were observed in both groups. Both drugs were well tolerated with no serious side effects reported by the patients. CONCLUSION Both drugs have comparable efficacy and safety when used as intermittent low dose regimen in hemodialysis. Larger studies with longer follow-up periods are needed to confirm our new findings.
Functional Evaluation of DC-SIGN Monoclonal Antibodies Reveals DC-SIGN Interactions with ICAM-3 Do Not Promote Human Immunodeficiency Virus Type 1 Transmission

ABSTRACT DC-SIGN, a type II membrane-spanning C-type lectin that is expressed on the surface of dendritic cells (DC), captures and promotes human and simian immunodeficiency virus (HIV and SIV) infection of CD4+ T cells in trans. To better understand the mechanism of DC-SIGN-mediated virus transmission, we generated and functionally evaluated a panel of seven monoclonal antibodies (MAbs) against DC-SIGN family molecules. Six of the MAbs reacted with myeloid-lineage DC, whereas one MAb preferentially bound DC-SIGNR/L-SIGN, a homolog of DC-SIGN. Characterization of hematopoietic cells also revealed that stimulation of monocytes with interleukin-4 (IL-4) or IL-13 was sufficient to induce expression of DC-SIGN. All DC-SIGN-reactive MAbs competed with intercellular adhesion molecule 3 (ICAM-3) for adhesion to DC-SIGN and blocked HIV-1 transmission to T cells that was mediated by THP-1 cells expressing DC-SIGN. Similar but less efficient MAb blocking of DC-mediated HIV-1 transmission was observed, indicating that HIV-1 transmission to target cells via DC may not be dependent solely on DC-SIGN. Attempts to neutralize DC-SIGN capture and transmission of HIV-1 with soluble ICAM-3 prophylaxis were limited in success, with a maximal inhibition of 60%. In addition, disrupting DC-SIGN/ICAM-3 interactions between cells with MAbs did not impair DC-SIGN-mediated HIV-1 transmission. Finally, forced expression of ICAM-3 on target cells did not increase their susceptibility to HIV-1 transmission mediated by DC-SIGN. While these findings do not discount the role of intercellular contact in facilitating HIV-1 transmission, our in vitro data indicate that DC-SIGN interactions with ICAM-3 do not promote DC-SIGN-mediated virus transmission.