Miracle-dz/UniFAR-FTUs huggingface dataset:
Factors Affecting Endothelin-Induced Venous Tone in Conscious Rats

There may be a relation between altered venous function, endothelin (ET)-1, and an impairment in the activity of endothelial-derived nitric oxide (NO) and prostanoids in salt-dependent hypertension. The present study examined the effects of salt intake on ET-induced changes in venomotor tone and the effects of blockade of NO synthase with NG-nitro-L-arginine methyl ester (L-NAME) and of cyclooxygenase with indomethacin on venomotor tone caused by the ETB selective agonist sarafotoxin 6c (S6c) in awake rats. Rats were anesthetized for permanent placement of catheters for measurements of arterial and venous pressures. A silicone balloon catheter was also fixed in the right atrium to produce brief circulatory arrest. Venomotor tone was estimated from measurements of mean circulatory filling pressure (MCFP) in conscious rats. There were no differences in mean arterial pressure, heart rate, or MCFP responses to short-term administration of ET-1 or S6c at different levels of salt intake. L-NAME or indomethacin did not change MCFP or the response of MCFP to short-term injection of S6c. In conclusion, neither basal MCFP nor integrated venomotor responses to short-term injection of ET-1 or S6c were altered by short-term changes in salt intake, blockade of NO synthase or cyclooxygenase. These data do not support the hypothesis that increased salt intake alters reactivity of veins to ET-1, NO, or prostanoids.
A First Look at Estimating the Relation between Spot and Futures Electricity Prices in the US

In this study we investigate the statistical properties of wholesale electricity spot and futures prices traded on the New York Mercantile Exchange for delivery at the California-Oregon Border. Using daily data for the years 1998 and 1999, we find that many of the characteristics of the electricity market can be viewed to be broadly consistent with efficient markets. The futures risk premium for six-month futures contracts is estimated to be about . 1328 percent per day or 4 percent per month. Using a GARCH specification, we estimate minimum variance hedge ratios for electricity futures. Finally, we model the dynamic relation between spot and futures prices using both an Exponential GARCH model and a vector autoregression representa-
EEG Investigations of Duration Discrimination: The Intermodal Effect Is Induced by an Attentional Bias

Previous studies indicated that empty time intervals are better discriminated in the auditory than in the visual modality, and when delimited by signals delivered from the same (intramodal intervals) rather than from different sensory modalities (intermodal intervals). The present electrophysiological study was conducted to determine the mechanisms which modulated the performances in inter- and intramodal conditions. Participants were asked to categorise as short or long empty intervals marked by auditory (A) and/or visual (V) signals (intramodal intervals: AA, VV; intermodal intervals: AV, VA). Behavioural data revealed that the performances were higher for the AA intervals than for the three other intervals and lower for inter- compared to intramodal intervals. Electrophysiological results indicated that the CNV amplitude recorded at fronto-central electrodes increased significantly until the end of the presentation of the long intervals in the AA conditions, while no significant change in the time course of this component was observed for the other three modalities of presentation. They also indicated that the N1 and P2 amplitudes recorded after the presentation of the signals which delimited the beginning of the intervals were higher for the inter- (AV/VA) compared to the intramodal intervals (AA/VV). The time course of the CNV revealed that the high performances observed with AA intervals would be related to the effectiveness of the neural mechanisms underlying the processing of the ongoing interval. The greater amplitude of the N1 and P2 components during the intermodal intervals suggests that the weak performances observed in these conditions would be caused by an attentional bias induced by the cognitive load and the necessity to switch between modalities.
Systematic review and meta‐analysis of triclosan‐coated sutures for the prevention of surgical‐site infection

Surgical‐site infections (SSIs) increase morbidity and mortality in surgical patients and represent an economic burden to healthcare systems. Experiments have shown that triclosan‐coated sutures (TCS) are beneficial in the prevention of SSI, although the results from individual randomized controlled trials (RCTs) are inconclusive. A meta‐analysis of available RCTs was performed to evaluate the efficacy of TCS in the prevention of SSI.
15‐LO/15‐HETE Mediated Vascular Adventitia Fibrosis via p38 MAPK‐Dependent TGF‐β

15‐Lipoxygenase/15‐hydroxyeicosatetraenoic acid (15‐LO/15‐HETE) is known to modulate pulmonary vascular medial hypertrophy and intimal endothelial cells migration and angiogenesis after hypoxia. However, it is unclear whether 15‐HETE affects the adventitia of the pulmonary arterial wall. We performed immunohistochemistry, adventitia fibrosis, pulmonary artery fibroblasts phenotype and extracellular matrix (ECM) deposition to determine the role of 15‐HETE in hypoxia‐induced pulmonary vascular adventitia remodeling. Our studies showed that O2 deprivation induced adventitia hypertrophy of pulmonary arteries with ECM accumulation in both humans with pulmonary arterial hypertension and hypoxic rats. Hypoxia induced 15‐LO expression in adventitia. With the inhibitor, NDGA depressed the hypoxia induced ECM deposition and 15‐LO production in hypoxic rats. Hypoxia up‐regulated the expression of α‐SMA, type‐Ia collagen and fibronectin in cultured fibroblasts, which seemed to be due to the increased 15‐LO/15‐HETE. Exogenous 15‐HETE mediated the ECM and phenotypic alterations of the fibroblasts as well. The 15‐LO/15‐HETE induced adventitia fibrosis and fibroblasts phenotypic alterations depended on signaling of the transforming growth factor‐β1 (TGF‐β1)/Smad2/3 pathway. P38 mitogen‐activated protein kinase (p38 MAPKs) was likely to mediate 15‐LO induced TGF‐β1 and Smad2/3 activation after hypoxia. The results suggest that adventitia fibrosis is an important event in the hypoxia induced pulmonary arterial remodeling, which relies on 15‐LO/15‐HETE induced p38 MAPK‐dependent TGF‐β1/Smad2/3 intracellular signaling systems. J. Cell. Physiol. 229: 245–257, 2014. © 2013 Wiley Periodicals, Inc.
Differential gene expression between human schwannoma and control Schwann cells

The NF2 gene encodes the tumour suppressor protein merlin. The mutation of a single allele of this gene causes the autosomal dominantly inherited disease neurofibromatosis type 2 (NF2), which is characterized mainly by vestibular schwannoma carrying a second hit mutation. Complete lack of merlin is also found in spontaneous schwannomas and meningiomas. As the events leading to schwannoma development are largely unknown we investigated the differences in gene expression between schwannoma cells from NF2 patients and normal human primary Schwann cells by cDNA array analysis. We identified 41 genes whose expression levels differed by more than factor 2. Most of these clones were corroborated by real‐time reverse transcription polymerase chain reaction analysis. By this method a total of seven genes with increased and seven genes with decreased mRNA levels in schwannoma compared with normal Schwann cells could be identified. Regulated clones, some of which not been described in Schwann cells earlier, included matrix metalloproteinase’s, growth factors, growth factor receptors and tyrosine kinases.
Hypoxia induces phenotypic plasticity and therapy resistance in melanoma via the tyrosine kinase receptors ROR1 and ROR2.

UNLABELLED An emerging concept in melanoma biology is that of dynamic, adaptive phenotype switching, where cells switch from a highly proliferative, poorly invasive phenotype to a highly invasive, less proliferative one. This switch may hold significant implications not just for metastasis, but also for therapy resistance. We demonstrate that phenotype switching and subsequent resistance can be guided by changes in expression of receptors involved in the noncanonical Wnt5A signaling pathway, ROR1 and ROR2. ROR1 and ROR2 are inversely expressed in melanomas and negatively regulate each other. Furthermore, hypoxia initiates a shift of ROR1-positive melanomas to a more invasive, ROR2-positive phenotype. Notably, this receptor switch induces a 10-fold decrease in sensitivity to BRAF inhibitors. In patients with melanoma treated with the BRAF inhibitor vemurafenib, Wnt5A expression correlates with clinical response and therapy resistance. These data highlight the fact that mechanisms that guide metastatic progression may be linked to those that mediate therapy resistance. SIGNIFICANCE These data show for the fi rst time that a single signaling pathway, the Wnt signaling pathway, can effectively guide the phenotypic plasticity of tumor cells, when primed to do so by a hypoxic microenvironment. Importantly, this increased Wnt5A signaling can give rise to a subpopulation of highly invasive cells that are intrinsically less sensitive to novel therapies for melanoma, and targeting the Wnt5A/ROR2 axis could improve the efficacy and duration of response for patients with melanoma on vemurafenib.
Simulation of Organ Patterning on the Floral Meristem Using a Polar Auxin Transport Model

An intriguing phenomenon in plant development is the timing and positioning of lateral organ initiation, which is a fundamental aspect of plant architecture. Although important progress has been made in elucidating the role of auxin transport in the vegetative shoot to explain the phyllotaxis of leaf formation in a spiral fashion, a model study of the role of auxin transport in whorled organ patterning in the expanding floral meristem is not available yet. We present an initial simulation approach to study the mechanisms that are expected to play an important role. Starting point is a confocal imaging study of Arabidopsis floral meristems at consecutive time points during flower development. These images reveal auxin accumulation patterns at the positions of the organs, which strongly suggests that the role of auxin in the floral meristem is similar to the role it plays in the shoot apical meristem. This is the basis for a simulation study of auxin transport through a growing floral meristem, which may answer the question whether auxin transport can in itself be responsible for the typical whorled floral pattern. We combined a cellular growth model for the meristem with a polar auxin transport model. The model predicts that sepals are initiated by auxin maxima arising early during meristem outgrowth. These form a pre-pattern relative to which a series of smaller auxin maxima are positioned, which partially overlap with the anlagen of petals, stamens, and carpels. We adjusted the model parameters corresponding to properties of floral mutants and found that the model predictions agree with the observed mutant patterns. The predicted timing of the primordia outgrowth and the timing and positioning of the sepal primordia show remarkable similarities with a developing flower in nature.
A case-control study of risk factors for male infertility in Nigeria.

AIM To evaluate the association between selected potential socio-demographic and behavioral risk factors and infertility in Nigerian men. METHODS There were two groups in this study. One group consisted of 150 men with proven male infertility, and the other consisted of 150 fertile men with normal semen parameters. Both were matched for age, place of residence and key socio-demographic variables. They were compared for sexual history, past medical and surgical history, past exposures to sexually transmitted infections and treatment, past and current use of drugs as well as smoking and alcohol intake history. RESULTS Infertile men were significantly more likely than fertile men to report having experienced penile discharge, painful micturition and genital ulcers, less likely to seek treatment for these symptoms and more likely to seek treatment with informal sector providers. Multivariate analysis showed that male infertility was significantly associated with bacteria in semen cultures, self-reporting of previous use of traditional medications and moderate to heavy alcohol intake, but not with smoking and occupational types. CONCLUSION INFERTILITY is associated with various proxies of sexually transmitted infections (STIs) and poor healthcare-seeking behavior for STIs in Nigerian men.
Controlling Phase Noise in Oscillatory Interference Models of Grid Cell Firing

Oscillatory interference models account for the spatial firing properties of grid cells in terms of neuronal oscillators with frequencies modulated by the animal's movement velocity. The phase of such a “velocity-controlled oscillator” (VCO) relative to a baseline (theta-band) oscillation tracks displacement along a preferred direction. Input from multiple VCOs with appropriate preferred directions causes a grid cell's grid-like firing pattern. However, accumulating phase noise causes the firing pattern to drift and become corrupted. Here we show how multiple redundant VCOs can automatically compensate for phase noise. By entraining the baseline frequency to the mean VCO frequency, VCO phases remain consistent, ensuring a coherent grid pattern and reducing its spatial drift. We show how the spatial stability of grid firing depends on the variability in VCO phases, e.g., a phase SD of 3 ms per 125 ms cycle results in stable grids for 1 min. Finally, coupling N VCOs with similar preferred directions as a ring attractor, so that their relative phases remain constant, produces grid cells with consistently offset grids, and reduces VCO phase variability of the order square root of N. The results suggest a viable functional organization of the grid cell network, and highlight the benefit of integrating displacement along multiple redundant directions for the purpose of path integration.
An automated image processing method to quantify collagen fibre organization within cutaneous scar tissue

Standard approaches to evaluate scar formation within histological sections rely on qualitative evaluations and scoring, which limits our understanding of the remodelling process. We have recently developed an image analysis technique for the rapid quantification of fibre alignment at each pixel location. The goal of this study was to evaluate its application for quantitatively mapping scar formation in histological sections of cutaneous burns. To this end, we utilized directional statistics to define maps of fibre density and directional variance from Masson's trichrome‐stained sections for quantifying changes in collagen organization during scar remodelling. Significant increases in collagen fibre density are detectable soon after burn injury in a rat model. Decreased fibre directional variance in the scar was also detectable between 3 weeks and 6 months after injury, indicating increasing fibre alignment. This automated analysis of fibre organization can provide objective surrogate endpoints for evaluating cutaneous wound repair and regeneration.
Recessions, Housing Market Disruptions, and the Mobility of Workers

At the end of September 2010, the United States Census Bureau released the 2009 data from the American Community Survey (ACS). One of the questions that participants are asked in this survey is where they were living one year ago. The answer to this question is of particular interest to labor economists since it is one way to assess the degree to which workers are moving around the country to pursue jobs or educational opportunities. Data from the past 10 years of surveys reveal that the fraction of the population living in the same house as they were one year ago has fluctuated between 83.5 percent and 85.5 percent.
Short-term changes in magnetic resonance imaging and disease activity in response to infliximab

Objectives: To characterise and quantify short-term changes in local inflammation using magnetic resonance imaging (MRI), and to correlate the findings with clinical disease activity in response to infliximab in patients with spondyloarthritis. Methods: 28 consecutive patients with established spondyloarthritis under successful long-term treatment with infliximab underwent MRI immediately before and one week after re-administration of the TNF blocker. C-reactive protein and the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) were assessed at both time points. The MRI protocol included coronal and sagittal turbo-short T1 inversion recovery (STIR) images as well as contrast-enhanced sagittal T1-weighted, fat-suppressed images. Images were assessed in independent sessions using the ASspiMRI-a score, the signal-difference-to-noise ratios (SDNR) and volumetry to assess oedematous and inflamed tissues. Results: BASDAI values were expectedly low at study entry (3.3, SD 2.3). One week after administration of infliximab, 46% of patients reached a BASDAI 20, 39% a BASDAI 50. Kappa values for qualitative assessments and all measurements were excellent (range between 0.83 and 1.0) The ASspiMRI-a dropped most in the thoracic (3.3 points), less in the lumbar (1.21 points) and least in the cervical spine (0.38 points). The decrease of the ASspiMRI-a, the SDNR and the inflamed volumes in response to infliximab re-treatment was significant (p<0.01). The BASDAI showed a weak correlation with the ASspiMRI-a (r = 0.41). Conclusions: MRI proves to be a valid method to assess and quantify short-term effects of therapy in spondyloarthritis. Comparison between MRI and BASDAI changes show that the BASDAI may underestimate local inflammation. It suggests an explanation for the structural disease progression despite clinical remission.
A study of unidirectional swipe gestures on in-vehicle touch screens

Touch screens are increasingly used within modern vehicles, providing the potential for a range of gestures to facilitate interaction under divided attention conditions. This paper describes a study aiming to understand how drivers naturally make swipe gestures in a vehicle context when compared with a stationary setting. Twenty experienced drivers were requested to undertake a swipe gesture on a touch screen in a manner they felt was appropriate to execute a wide range of activate/deactivate, increase/decrease and next/previous tasks. All participants undertook the tasks when either driving within a right-hand drive, medium-fidelity simulator or whilst sitting stationary. Consensus emerged in the direction of swipes made for a relatively small number of increase/decrease and next/previous tasks, particularly related to playing music. The physical action of a swipe made in different directions was found to affect the length and speed of the gesture. Finally, swipes were typically made more slowly in the driving situation, reflecting the reduced resources available in this context and/or the handedness of the participants. Conclusions are drawn regarding the future design of swipe gestures for interacting with in-vehicle touch screens.
Extreme impact and cavitation forces of a biological hammer: strike forces of the peacock mantis shrimp Odontodactylus scyllarus

SUMMARY Mantis shrimp are renowned for their unusual method of breaking shells with brief, powerful strikes of their raptorial appendages. Due to the extreme speeds of these strikes underwater, cavitation occurs between their appendages and hard-shelled prey. Here we examine the magnitude and relative contribution of the impact and cavitation forces generated by the peacock mantis shrimp Odontodactylus scyllarus. We present the surprising finding that each strike generates two brief, high-amplitude force peaks, typically 390–480 μs apart. Based on high-speed imaging, force measurements and acoustic analyses, it is evident that the first force peak is caused by the limb's impact and the second force peak is due to the collapse of cavitation bubbles. Peak limb impact forces range from 400 to 1501 N and peak cavitation forces reach 504 N. Despite their small size, O. scyllarus can generate impact forces thousands of times their body weight. Furthermore, on average, cavitation peak forces are 50% of the limb's impact force, although cavitation forces may exceed the limb impact forces by up to 280%. The rapid succession of high peak forces used by mantis shrimp suggests that mantis shrimp use a potent combination of cavitation forces and extraordinarily high impact forces to fracture shells. The stomatopod's hammer is fundamentally different from typical shell-crushing mechanisms such as fish jaws and lobster claws, and may have played an important and as yet unexamined role in the evolution of shell form.
Is the rate of molecular evolution inversely related to body size?

The wealth of molecular data generated over the past two decades has led to the documentation of highly disparate rates of molecular evolution among different taxa. Among the more intriguing studies is that of Martin and Palumbi (1993), who presented data (their Table 2) derived from a variety of vertebrate taxa purporting to show that the rate of molecular evolution is inversely correlated with body size (and its correlates: metabolic rate, generation time, etc.). Their hypothesis has been cited as a possible ex? planation for variation in rate of molecular evolution among different taxa (e.g., Hafner et al., 1994; Rand, 1994; Stewart and Baker, 1994). We argue, however, that no such re? lationship is evidenced from Martin and Palumbi's data and that the problem lies in the fact that their distance-based estimates for the rate of molecular evolution were un-
Understanding what is visible in a mirror or through a window before and after updating the position of an object

In the Venus effect observers assume that Venus is admiring her own reflection in the mirror (Bertamini et al., 2003a). However, since the observer sees her face in the mirror, Venus is actually looking at the reflection of the painter. This effect is general because it is not specific to paintings or to images of people. This study tests whether people have difficulties in estimating what is visible from a given viewpoint using a paper and pencil task. Participants (N = 80) judged what is visible in a scene that could include a mirror or an aperture. The object in the scene (a train) was already located in front of the mirror or behind the aperture, or the same object had to be imagined to move to that location. The hypothesis was that this extra step (spatial transformation) is always part of how people reason about mirrors because they have to imagine the location of the reflection based on the location of the physical object. If so, this manipulation would equate the difficulty of the mirror and of the aperture conditions. Results show that performance on the paper and pencil task was better than expected, probably because of the asymmetric nature of the object used. However, an additional cost in reasoning about mirrors was confirmed.
Market Liquidity and Trading Activity

Previous studies of liquidity span short time periods and focus on the individual security. In contrast, we study aggregate market spreads, depths, and trading activity for U.S. equities over an extended time sample. Daily changes in market averages of liquidity and trading activity are highly volatile and negatively serially dependent. Liquidity plummets significantly in down markets. Recent market volatility induces a decrease in trading activity and spreads. There are strong day-of-the-week effects; Fridays accompany a significant decrease in trading activity and liquidity, while Tuesdays display the opposite pattern. Long- and short-term interest rates influence liquidity. Depth and trading activity increase just prior to major macroeconomic announcements. Copyright The American Finance Association 2001.