Miracle-dz/UniFAR-FTUs huggingface dataset:
Perceptions of Spirituality and Spiritual Care of Health Professionals Working in a State Hospital

Background: The determination and fulfillment of the spiritual needs of the individual in times of crisis can be realized by the health care professionals having the knowledge and skills to provide individual-specific care. This research was conducted to determine the perceptions of health professionals about spirituality and spiritual care. Methods: The study of 197 health professionals working in a state hospital was performed. This study is a descriptive study which was conducted between December 2017 and January 2018. Data in the form of an “Introductory Information Form” and “Spirituality and Spiritual Care Grading Scale” was collected. In the analysis of the data, the Mann–Whitney U test, Kruskal–Wallis tests, frequency as percentage, and scale scores as mean and standard deviation were used. Results: It was determined that 45.7% of the health professionals were trained in spiritual care, but that they were unable to meet their patients’ spiritual care needs due to the intensive work environment and personnel insufficiency. The total score averaged by the health professionals on the spirituality and spiritual care grading scales was 52.13 ± 10.13. Conclusions: The findings of the research show that health professionals are inadequate in spiritual care initiatives and that their knowledge levels are not at the desired level. With in-service trainings and efforts to address these deficiencies, spiritual care initiatives can be made part of the recovery process.
Bilirubin From Heme Oxygenase-1 Attenuates Vascular Endothelial Activation and Dysfunction

Objective— Heme oxygenase-1 (HO-1), the rate-limiting enzyme of heme degradation, has recently been considered to have protective roles against various pathophysiological conditions. Since we demonstrated that HO-1 overexpression inhibits atherosclerotic formation in animal models, we examined the effect of HO modulation on proinflammatory cytokine production, endothelial NO synthase (eNOS) expression, and endothelium-dependent vascular relaxation responses. Methods and Results— After HO-1 induction by heme arginate (HA), vascular endothelial cell cultures were exposed to oxidized low-density lipoprotein (oxLDL) or tumor necrosis factor-α (TNF-α). HA pretreatment significantly attenuated the production of vascular cell adhesion molecule-1, monocyte chemotactic protein-1, and macrophage colony-stimulating factor, suggesting that HO-1 induction attenuates proinflammatory responses. In addition, HO-1 overexpression also alleviated endothelial dysfunction as judged by restoration of attenuated eNOS expression after exposure to oxLDL and TNF-α. Importantly, impaired endothelium-dependent vascular relaxation responses in thoracic aortic rings from high-fat–fed LDL receptor knockout mice were also improved. These effects were observed by treatment with bilirubin not by carbon monoxide. Conclusions— These results suggest that the antiatherogenic properties of HO-1 may be mediated predominantly through the action of bilirubin by inhibition of vascular endothelial activation and dysfunction in response to proinflammatory stresses.
Cold Storage of Rat Hepatocyte Suspensions for One Week in a Customized Cold Storage Solution – Preservation of Cell Attachment and Metabolism

Background & Aims Primary hepatocytes are of great importance for basic research as well as cell transplantation. However, their stability, especially in suspension, is very low. This feature severely compromises storage and shipment. Based on previous studies with adherent cells, we here assessed cold storage injury in rat hepatocyte suspensions and aimed to find a cold storage solution that preserves viability, attachment ability and functionality of these cells. Methods Rat hepatocyte suspensions were stored in cell culture medium, organ preservation solutions and modified TiProtec solutions at 4°C for one week. Viability and cell volume were determined by flow cytometry. Thereafter, cells were seeded and density and metabolic capacity (reductive metabolism, forskolin-induced glucose release, urea production) of adherent cells were assessed. Results Cold storage injury in hepatocyte suspensions became evident as cell death occurring during cold storage or rewarming or as loss of attachment ability. Cell death during cold storage was not dependent on cell swelling and was almost completely inhibited in the presence of glycine and L-alanine. Cell attachment could be greatly improved by use of chloride-poor solutions and addition of iron chelators. Using a chloride-poor, potassium-rich storage solution containing glycine, alanine and iron chelators, cultures with 75% of the density of control cultures and with practically normal cell metabolism could be obtained after one week of cold storage. Conclusion In the solution presented here, cold storage injury of hepatocyte suspensions, differing from that of adherent hepatocytes, was effectively inhibited. The components which acted on the different injurious processes were identified.
Explorations of Creativity A review for educators and policy making

wise matters 0 2 2 Wise was established by Qatar foundation in 2009 under the patronage of its Chairperson, Her Highness sheikha moza bint nasser. Wise is an international, multi-sectoral platform for creative thinking, debate and purposeful action. through both the annual summit and a range of ongoing programs Wise is promoting innovation and building the future of education through collaboration. As a global reference for new approaches in education, Wise is committed to creating and facilitating access to knowledge and information. the Wise Matters series, launched as part of this mission, presents timely, comprehensive reviews of key issues in education. these publications, produced in collaboration with recognized experts and thinkers, will include examples of improved practice from around the world, as well as recommendations for policy – makers and educators – and for societies. the views, opinions, and choices of presentation in this publication are solely those of the authors.
pix-1 Controls Early Elongation in Parallel with mel-11 and let-502 in Caenorhabditis elegans

Cell shape changes are crucial for metazoan development. During Caenorhabditis elegans embryogenesis, epidermal cell shape changes transform ovoid embryos into vermiform larvae. This process is divided into two phases: early and late elongation. Early elongation involves the contraction of filamentous actin bundles by phosphorylated non-muscle myosin in a subset of epidermal (hypodermal) cells. The genes controlling early elongation are associated with two parallel pathways. The first one involves the rho-1/RHOA-specific effector let-502/Rho-kinase and mel-11/myosin phosphatase regulatory subunit. The second pathway involves the CDC42/RAC-specific effector pak-1. Late elongation is driven by mechanotransduction in ventral and dorsal hypodermal cells in response to body-wall muscle contractions, and involves the CDC42/RAC-specific Guanine-nucleotide Exchange Factor (GEF) pix-1, the GTPase ced-10/RAC and pak-1. In this study, pix-1 is shown to control early elongation in parallel with let-502/mel-11, as previously shown for pak-1. We show that pix-1, pak-1 and let-502 control the rate of elongation, and the antero-posterior morphology of the embryos. In particular, pix-1 and pak-1 are shown to control head, but not tail width, while let-502 controls both head and tail width. This suggests that let-502 function is required throughout the antero-posterior axis of the embryo during early elongation, while pix-1/pak-1 function may be mostly required in the anterior part of the embryo. Supporting this hypothesis we show that low pix-1 expression level in the dorsal-posterior hypodermal cells is required to ensure high elongation rate during early elongation.
The effects of stellar winds on the magnetospheres and potential habitability of exoplanets

Context. The principle definition of habitability for exoplanets is whether they can sustain liquid water on their surfaces, i.e. that they orbit within the habitable zone. However, the planet’s magnetosphere should also be considered, since without it, an exoplanet’s atmosphere may be eroded away by stellar winds. Aims. The aim of this paper is to investigate magnetospheric protection of a planet from the effects of stellar winds from solar-mass stars. Methods. We study hypothetical Earth-like exoplanets orbiting in the host star’s habitable zone for a sample of 124 solar-mass stars. These are targets that have been observed by the Bcool Collaboration. Using two wind models, we calculate the magnetospheric extent of each exoplanet. These wind models are computationally inexpensive and allow the community to quickly estimate the magnetospheric size of magnetised Earth-analogues orbiting cool stars. Results. Most of the simulated planets in our sample can maintain a magnetosphere of ∼5 Earth radii or larger. This suggests that magnetised Earth analogues in the habitable zones of solar analogues are able to protect their atmospheres and is in contrast to planets around young active M dwarfs. In general, we find that Earth-analogues around solar-type stars, of age 1.5 Gyr or older, can maintain at least a Paleoarchean Earth sized magnetosphere. Our results indicate that planets around 0.6–0.8 solar-mass stars on the low activity side of the Vaughan-Preston gap are the optimum observing targets for habitable Earth analogues.
Potentiation by interleukin 2 of Burkitt's lymphoma therapy with anti-pan B (anti-CD19) monoclonal antibodies in a mouse xenotransplantation model.

To study the immunotherapeutic potential of monoclonal antibodies (mAbs) directed against the human pan-B-cell antigen CD19, a xenotransplantation model was developed in which the human Burkitt's cell line Daudi is s.c. transplanted into nude mice. IgG1, IgG2b, and IgG2a isotype variants of the anti-CD19 mAb (CLB-CD19) were tested for their capacity to inhibit the growth of 10 x 10(6) Daudi cells injected s.c. into nude mice. When mAb treatment was started 30 min after the injection of tumor cells, only the IgG2a isotype of CLB-CD19 had a marked antitumor effect in vivo. If treatment with IgG2a anti-CD19 mAb alone was delayed until Day 10 after tumor injection, no therapeutic effect was observed. However, the combination of this delayed mAb treatment with recombinant interleukin 2 (rIL-2) inhibited the growth of the Daudi cells in the nude mice, while treatment with rIL-2 alone was ineffective. The results of in vitro experiments showed that peritoneal exudate cells were able to inhibit the proliferation of Daudi cells in the presence of the IgG2a isotype variant of CLB-CD19 mAb but not in the presence of the other CLB-CD19 mAb isotype variants. Fresh nude mouse spleen cells did not mediate antibody-dependent cellular cytotoxicity against CLB-CD19 mAb-sensitized Daudi cells, irrespective of the isotype used for sensitization. However, preculture of these spleen cells with rIL-2 induced antibody-dependent cellular cytotoxicity against CD19+ target cells sensitized with CLB-CD19 mAb of all isotypes. These results indicate that it is possible to enhance mAb-dependent effector systems in vivo with the lymphokine rIL-2.
Functional representation as design rationale

The functional representation (FR) framework, which captures the causal component of a design rationale (DR), is described. FR encodes the designer's account of the causal processes in the device that culminate in achieving its function. The representation makes explicit the components' roles in the causal process. The limitations of FR as a design rationale and the limitations of the current repertoire of representational primitives in FR for capturing the causal component are discussed. <<ETX>>
Gastrointestinal endoscopy in patients on anticoagulant therapy and antiplatelet agents

Periprocedural management of antithrombotics for gastrointestinal endoscopy is a common clinical issue, given the widespread use of these drugs for primary and secondary cardiovascular prevention. For diagnostic procedures, with or without biopsy, no adjustments in antithrombotics are usually needed. For operative procedures, balancing the risk of periprocedural hemorrhage with the continuation of antithrombotics against the chance of recurrent thromboembolic events with their discontinuation may be challenging. Oral anticoagulants need to be temporarily withheld, and consideration must be given to whether a periendoscopic “bridge” therapy, typically a low-molecular-weight heparin, should be used in order to minimize the risk of thromboembolic events. Although some emerging evidence has shown that patients receiving heparin bridging appear to be at increased risk of overall and major bleeding and at similar risk of thromboembolic events compared to controls, bridging therapy is still recommended for patients on vitamin K antagonists who are at high thrombotic risk. Conversely, bridging therapy is usually not needed for patients taking new oral agents, which are characterized by shorter half-lives, and a rapid offset and onset of action. Management of antiplatelet therapy requires special care in patients on secondary prevention, especially those with coronary stents. This review is intended to summarize the recommendations of updated International Guidelines designed to help the decision-making process in such an intricate field.
Hochschild Cohomology and Moduli Spaces of Strongly Homotopy Associative Algebras

Motivated by ideas from stable homotopy theory we study the space of strongly ho-motopy associative multiplications on a two-cell chain complex. In the simplest case this moduli space is isomorphic to the set of orbits of a group of invertible power series acting on a certain space. The Hochschild cohomology rings of resulting A∞-algebras have an interpretation as totally ramified extensions of discrete valuation rings. All A∞-algebras are supposed to be unital and we give a detailed analysis of unital structures which is of independent interest.
Go Long or Go Often: Influences on Binge Watching Frequency and Duration among College Students

Binge watching, or serial viewing of a single program over an extended period of time, is a relatively new norm in television viewing that is becoming more popular than traditional appointment viewing. Previous research has explored various influences on binge watching; however, the current research is unique in exploring theoretically and empirically grounded predictors of both binge watching frequency and duration of binge watching sessions by means of a survey administered to college undergraduates (N = 651). Data show that binge watching frequency and duration are predicted by two non-overlapping sets of variables. Binge watching frequency was predicted by low self-regulation, greater tendency to use binge watching as both a reward and a form of procrastination, and less regret; while binge watching duration was associated with being female and experiencing greater enjoyment while binging. Self-control did not predict either binge watching frequency or duration, suggesting that alternative theoretical models should be explored. Findings also suggest that scholars should reconceptualize binge watching by including both frequency and duration measures in future studies.
To Parallelize or Not to Parallelize, Speed Up Issue

Running parallel applications requires special and expensive processing resources to obtain the required results within a reasonable time. Before parallelizing serial applications, some analysis is recommended to be carried out to decide whether it will benefit from parallelization or not. In this paper we discuss the issue of speed up gained from parallelization using Message Passing Interface (MPI) to compromise between the overhead of parallelization cost and the gained parallel speed up. We also propose an experimental method to predict the speed up of MPI applications.
Moving objects with 2D input devices in CAD systems and Desktop Virtual Environments

Part assembly and scene layout are basic tasks in 3D design in Desktop Virtual Environment (DVE) systems as well as Computer Aided Design (CAD) systems. 2D input devices such as a mouse or a stylus are still the most common input devices for such systems. With such devices, a notably difficult problem is to provide an efficient and predictable object motion in 3D based on their 2D motion. This paper presents a new technique to move objects in CAD/DVE using 2D input devices.The technique presented in this paper utilizes the fact that people easily recognize the depth-order of shapes based on occlusions. In the presented technique, the object position follows the mouse cursor position, while the object slides on various surfaces in the scene. In contrast to existing techniques, the movement surface and the relative object position is determined using the whole area of overlap of the moving object with the static scene. The resulting object movement is visually smooth and predictable, while avoiding undesirable collisions. The proposed technique makes use of the framebuffer for efficiency and runs in real-time. Finally, the evaluation of the new technique with a user study shows that it compares very favorably to conventional techniques.
Aspect-Level Sentiment Analysis Based on a Generalized Probabilistic Topic and Syntax Model

A number of topic models have been proposed for sentiment analysis in recent years, which rely on extensions of the basic LDA model. In this paper, we apply a generalized topic and syntax model called Part-of-Speech LDA (POSLDA) to sentiment analysis, and propose several feature selection methods that separate entities from the modifiers that describe the entities. Along with a Maximum Entropy classifier, we can use the selected features to conduct sentiment analysis at both document and aspect levels. The advantage of using POSLDA is that we can automatically separate semantic and syntactic classes, and easily extend it to aspect level sentiment analysis by mapping topics to aspects. However, words in the noun-related classes, which are also treated as semantic classes, should be removed as much as possible to reduce their impact on sentiment analysis. To evaluate the effectiveness of our solutions, we conducted experiments on two collections of review documents and obtained the accuracy results competitive to the previous work on sentiment analysis.
Quantification of the Contribution of Cardiac and Arterial Remodeling to Hypertension

The study aim was to quantify the individual and combined contributions of both the arterial system and the heart to systolic blood pressure in hypertension. We assessed the parameters of a heart–arterial model for normotensive control subjects and hypertensive patients with left ventricular adaptation patterns classified as normal, concentric remodeling, concentric hypertrophy, or eccentric hypertrophy. The present simulations show that vascular stiffening alone increases the pulse pressure without increasing systolic blood pressure. It is only in combination with an increased peripheral resistance that arterial stiffening leads to systolic hypertension in concentric remodeling and concentric hypertrophy. The contribution of cardiac pump function to the increase in blood pressure depends on cardiac remodeling, hypertrophy, or both. In hypertensive patients with a normal left ventricle, the heart is responsible for 55% of the increase in systolic blood pressure. In concentric remodeling, concentric hypertrophy, and eccentric hypertrophy, the cardiac contribution to the increase in systolic blood pressure is 21%, 65%, and 108%, respectively. We conclude that along with arterial changes, cardiac remodeling and hypertrophy contribute to hypertension.
Intergenerational Schooling Mobility and Macro Conditions and Schooling Policies in Latin America

The effects of market and policy reforms on poverty and inequality in Latin America have been of considerable concern. The region continues to have relatively great income inequalities. Two different societies with the same income distribution may have different levels of social welfare because they have different degrees of social mobility. To date little attention has been paid to measuring social mobility in the region. Schooling is thought to be a major mechanism through which intergenerational social mobility is affected. This paper explores the strength of the association of family background with child schooling and whether the strength of this association is related to some major macro and aggregate school policy variables.
CYC: a large-scale investment in knowledge infrastructure

Since 1984, a person-century of effort has gone into building CYC, a universal schema of roughly 105 general concepts spanning human reality. Most of the time has been spent codifying knowledge about these concepts; approximately 106 commonsense axioms have been handcrafted for and entered into CYC's knowledge base, and millions more have been inferred and cached by CYC. This article examines the fundamental assumptions of doing such a large-scale project, reviews the technical lessons learned by the developers, and surveys the range of applications that are or soon will be enabled by the technology.
Sirtuin-2 inhibition affects hippocampal functions and sodium butyrate ameliorates the reduction in novel object memory, cell proliferation, and neuroblast differentiation

We investigated the effects of the sirtuin-2 (SIRT2) inhibitor AK-7 on novel object memory, cell proliferation, and neuroblast differentiation in the dentate gyrus. In addition, we also observed the relationships with sodium butyrate, a histone deacetylase inhibitor, on the hippocampal functions. To investigate the effects of AK-7 on hippocampal functions, 10-week-old C57BL/6 mice were daily injected intraperitoneally with 20 mg/kg AK-7 alone or in combination with subcutaneous administration of 300 mg/kg sodium butyrate, a histone deacetylase inhibitor, for 21 days. A novel object recognition test was conducted on days 20 (training) and 21 (testing) of treatment. Thereafter, the animals were sacrificed for immunohistochemistry for Ki67 (cell proliferation) and doublecortin (DCX, neuroblast differentiation). AK-7 administration significantly reduced the time spent exploring new objects, while treatment in combination with sodium butyrate significantly alleviated this reduction. Additionally, AK-7 administration significantly reduced the number of Ki67-positive cells and DCX-immunoreactive neuroblasts in the dentate gyrus, while the treatment in combination with sodium butyrate ameliorated these changes. This result suggests that the reduction of SIRT2 may be closely related to age-related phenotypes including novel object memory, as well as cell proliferation and neuroblast differentiation in the dentate gyrus. In addition, sodium butyrate reverses SIRT2-related age phenotypes.