Miracle-dz/UniFAR-FTUs huggingface dataset:
Outcomes of some surgical fixation techniques for supracondylar femoral fractures : a comparative study

Supracondylar fracture of the femur is a composite injury that poses challenge for the orthopaedist to manage. The potential long-term disability is the culprit behind this problem. Thus, choice of a suitable treatment option for any case of supracondylar femur fracture is a vital task. In our study, a total of 193 patients were enrolled, of which 158 patients were randomly subjected to various operative procedures, viz., fixed angle blade plate method, supracondylar nailing and locking compression plate method. The treatment outcomes depicted that the patients who had undergone locking compression plate established 86.5% of improvement in the movement whereas the patients with supracondylar nail and fixed-angle blade plate methods reported only 56.6% and 53.8% respectively. Besides, 90.4% patients in locking compression plate group resumed to normal activities earlier and only 9.6% were delayed. But, only 47.2% of patients of supracondylar nail method recovered earlier and 52.8% of patients delayed to resume their normal activities. Similarly, only 46.2% of patients engaged in fixed-angle blade plate operative method were reported with early resumption and 53.8% depicted delayed resumption to normal activities. From this comparative study, we inferred that the locking compression plate method provides a better outcome in the treatment of supracondylar fracture of the femur.
Communication and Organizational Culture: A Key to Understanding Work Experiences

Section One: Positioning Organizational Culture Introduction What is an Organization? What is Organizational Communication? What is Culture? What is Organizational Culture? Integration of Artifacts, Values, and Assumptions Organizational Culture and You Feature: Does Organizational Culture Really Matter? Summary Section Two: Unpacking Organizational Culture Core Characteristics of Organizational Culture Communicating Culture The Structure of Organizational Culture A Divided View of Organizational Culture Cultural Consensus and Division What Organizational Culture is Not Feature: Organizational Culture or Organizational Climate Myths about Organizational Culture Summary Section Three: Lenses for Understanding Organizational Culture The Development of Organizational Culture Construct The Lens of Symbolic Performance The Lens of Narrative Reproduction The Lens of Textual Reproduction Feature: The Two Sides of Managerial Views The Lens of Power and Politics The Lens of Technology The Lens of Globalization Summary Section Four: Developing, Managing, and Changing Organizational Culture Culture Formation Cultural Maintenance Cultural Change in Organizations Feature: Two Levels for Addressing Cultural Change Creating a Vision of the Organization and its Culture Socializing New Employees to the Culture Leadership and Organizational Culture Personal, Professional, and Organizational Ethics Can Organizational Culture be Managed? Summary The Culture Toolkit: Methods for Exploring Organizational Culture Steps in Coducting a Cultural Analysis Cultural Tools Putting It All Together Summary Appendix
The Study of the Relationship between Organizational Justice and Job Satisfaction on Y-Generation in Chinese IT Industry

Research on job satisfaction of employees has always been a hot spot in Human Resource Management. This study examined the relationship between three forms of organizational justice and job satisfaction on Post-'80 generation employees in Chinese IT industry. Survey data were collected from 198 IT personnel employed coming from ten IT enterprises in two cities of China via a combination of mail survey and paper questionnaire. Bivariate analysis revealed that there were significantly relationship between three forms of organizational justice and job satisfaction. The further hierarchical regression results supported a main effects model of the distributive justice and procedural justice to job satisfaction. Implications of the research findings are discussed.
Two-pore channel 1 interacts with citron kinase, regulating completion of cytokinesis

Two-pore channels (TPC1, 2, and 3) are recently identified endolysosmal ion channels, but remain poorly characterized. In this study, we show for the first time a role for TPC1 in cytokinesis, the final step in cell division. HEK 293 T-REx cells inducibly overexpressing TPC1 demonstrated a lack of proliferation accompanied by multinucleation and an increase in G2/M cycling cells. Increased TPC1 was associated with a concomitant accumulation of active RhoGTP and a decrease in phosphorylated myosin light chain (MLC). Finally, we demonstrated a novel interaction between TPC1 and citron kinase (CIT). These results identify TPC1 as a central component of cytokinetic control, specifically during abscission, and introduce a means by which the endolysosomal system may play an active role in this process.
Identification of a Breast Cancer Susceptibility Locus at 4q31.22 Using a Genome-Wide Association Study Paradigm

More than 40 single nucleotide polymorphisms (SNPs) for breast cancer susceptibility were identified by genome-wide association studies (GWASs). However, additional SNPs likely contribute to breast cancer susceptibility and overall genetic risk, prompting this investigation for additional variants. Six putative breast cancer susceptibility SNPs identified in a two-stage GWAS that we reported earlier were replicated in a follow-up stage 3 study using an independent set of breast cancer cases and controls from Canada, with an overall cumulative sample size of 7,219 subjects across all three stages. The study design also encompassed the 11 variants from GWASs previously reported by various consortia between the years 2007–2009 to (i) enable comparisons of effect sizes, and (ii) identify putative prognostic variants across studies. All SNP associations reported with breast cancer were also adjusted for body mass index (BMI). We report a strong association with 4q31.22-rs1429142 (combined per allele odds ratio and 95% confidence interval = 1.28 [1.17–1.41] and P combined = 1.5×10−7), when adjusted for BMI. Ten of the 11 breast cancer susceptibility loci reported by consortia also showed associations in our predominantly Caucasian study population, and the associations were independent of BMI; four FGFR2 SNPs and TNRC9-rs3803662 were among the most notable associations. Since the original report by Garcia-Closas et al. 2008, this is the second study to confirm the association of 8q24.21-rs13281615 with breast cancer outcomes.
Odd-skipped related 1 is required for development of the metanephric kidney and regulates formation and differentiation of kidney precursor cells

Formation of kidney tissue requires the generation of kidney precursor cells and their subsequent differentiation into nephrons, the functional filtration unit of the kidney. Here we report that the gene odd-skipped related 1 (Odd1) plays an important role in both these processes. Odd1 is the earliest known marker of the intermediate mesoderm, the precursor to all kidney tissue. It is localized to mesenchymal precursors within the mesonephric and metanephric kidney and is subsequently downregulated upon tubule differentiation. Mice lacking Odd1 do not form metanephric mesenchyme, and do not express several other factors required for metanephric kidney formation, including Eya1, Six2, Pax2, Sall1 and Gdnf. In transient ectopic expression experiments in the chick embryo, Odd1 can promote expression of the mesonephric precursor markers Pax2 and Lim1. Finally, persistent expression of Odd1 in chick mesonephric precursor cells inhibits differentiation of these precursors into kidney tubules. These data indicate that Odd1 plays an important role in establishing kidney precursor cells, and in regulating their differentiation into kidney tubular tissue.
Improved constraints on dark energy from Chandra X-ray observations of the largest relaxed galaxy clusters

We present constraints on the mean matter density, � m, dark energy density, � DE, and the dark energy equation of state parameter, w, using Chandra measurements of the X-ray gas mass fraction (fgas )i n 42 hot (kT > 5 keV), X-ray luminous, dynamically relaxed galaxy clusters spanning the redshift range 0.05 < z < 1.1. Using only the fgas data for the six lowest redshift clusters at z < 0.15, for which dark energy has a negligible effect on the measurements, we measurem = 0.28 ± 0.06 (68 per cent confidence limits, using standard priors on the Hubble constant, H0, and mean baryon density, � b h 2 ). Analysing the data for all 42 clusters, employ- ing only weak priors on H0 andb h 2 , we obtain a similar result onm and a detection of the effects of dark energy on the distances to the clusters at ∼99.99 per cent confidence, with � DE = 0.86 ± 0.21 for a non-flatCDM model. The detection of dark energy is comparable in significance to recent type Ia supernovae (SNIa) studies and represents strong, independent evidence for cosmic acceleration. Systematic scatter remains undetected in the fgas data, despite a weighted mean statistical scatter in the distance measurements of only ∼5 per cent. For a flat cosmology with a constant dark energy equation of state, we measurem = 0.28 ± 0.06 and w =− 1.14 ± 0.31. Combining the fgas data with independent constraints from cosmic mi- crowave background and SNIa studies removes the need for priors onb h 2 and H0 and leads to tighter constraints: � m = 0.253 ± 0.021 and w =− 0.98 ± 0.07 for the same constant-w model. Our most general analysis allows the equation of state to evolve with redshift. Marginalizing over possible transition redshifts 0.05 < zt < 1, the combined fgas + CMB + SNIa data set constrains the dark energy equation of state at late and early times to be w0 =− 1.05 ± 0.29 and wet =− 0.83 ± 0.46, respectively, in agreement with the cosmological constant paradigm. Relaxing the assumption of flatness weakens the constraints on the equation of state by only a factor of ∼2. Our analysis includes conservative allowances for systematic uncertainties as- sociated with instrument calibration, cluster physics and data modelling. The measured small systematic scatter, tight constraint onm and powerful constraints on dark energy from the fgas data bode well for future dark energy studies using the next generation of powerful X-ray observatories, such as Constellation-X.
Regression Testing Web Services-based Applications

Web applications can be composed of heterogeneous selfcontained web services. Such applications are usually modified to fix errors or to enhance their functionality. After modifications, regression testing is essential to ensure that modifications do not lead to adverse effects. In this paper, we present a safe regression testing algorithm that selects an adequate number of non-redundant test sequences aiming to find modification-related errors. In our technique, a web application and the behavior of its composed components are specified by a two-level abstract model represented as a Timed Labeled Transition System. Our algorithm selects every test sequence that corresponds to a different behavior in the modified system. We discuss three situations for applying this algorithm: (1) connecting to a newly established web service that fulfills a composed web service, (2) adding or removing an operation in any of the composed web services, (3) modifying the specification of the web application. Moreover, modifications handled by the algorithm are classified into three classes: (a) adding an operation, (b) deleting an operation, (c) fixing a condition or an action. Key-words : label transition systems, testing, verification, web service, web application.
Benchmarks for acute stroke care delivery

Objective Despite widespread interest in many jurisdictions in monitoring and improving the quality of stroke care delivery, benchmarks for most stroke performance indicators have not been established. The objective of this study was to develop data-derived benchmarks for acute stroke quality indicators. Design Nine key acute stroke quality indicators were selected from the Canadian Stroke Best Practice Performance Measures Manual. Participants A population-based retrospective sample of patients discharged from 142 hospitals in Ontario, Canada, between 1 April 2008 and 31 March 2009 (N = 3191) was used to calculate hospital rates of performance and benchmarks. Intervention The Achievable Benchmark of Care (ABC™) methodology was used to create benchmarks based on the performance of the upper 15% of patients in the top-performing hospitals. Main Outcome Measures Benchmarks were calculated for rates of neuroimaging, carotid imaging, stroke unit admission, dysphasia screening and administration of stroke-related medications. Results The following benchmarks were derived: neuroimaging within 24 h, 98%; admission to a stroke unit, 77%; thrombolysis among patients arriving within 2.5 h, 59%; carotid imaging, 93%; dysphagia screening, 88%; antithrombotic therapy, 98%; anticoagulation for atrial fibrillation, 94%; antihypertensive therapy, 92% and lipid-lowering therapy, 77%. ABC™ acute stroke care benchmarks achieve or exceed the consensus-based targets required by Accreditation Canada, with the exception of dysphagia screening. Conclusions Benchmarks for nine hospital-based acute stroke care quality indicators have been established. These can be used in the development of standards for quality improvement initiatives.
Saccadic gain modification: visual error drives motor adaptation.

The brain maintains the accuracy of saccadic eye movements by adjusting saccadic amplitude relative to the target distance (i.e., saccade gain) on the basis of the performance of recent saccades. If an experimenter surreptitiously moves the target backward during each saccade, thereby causing the eyes to land beyond their targets, saccades undergo a gradual gain reduction. The error signal driving this conventional saccadic gain adaptation could be either visual (the postsaccadic distance of the target from the fovea) or motoric (the direction and size of the corrective saccade that brings the eye onto the back-stepped target). Similarly, the adaptation itself might be a motor adjustment (change in the size of saccade for a given perceived target distance) or a visual remapping (change in the perceived target distance). We studied these possibilities in experiments both with rhesus macaques and with humans. To test whether the error signal is motoric, we used a paradigm devised by Heiner Deubel. The Deubel paradigm differed from the conventional adaptation paradigm in that the backward step that occurred during the saccade was brief, and the target then returned to its original displaced location. This ploy replaced most of the usual backward corrective saccades with forward ones. Nevertheless, saccadic gain gradually decreased over hundreds of trials. Therefore, we conclude that the direction of saccadic gain adaptation is not determined by the direction of corrective saccades. To test whether gain adaptation is a manifestation of a static visual remapping, we decreased the gain of 10 degrees horizontal saccades by conventional adaptation and then tested the gain to targets appearing at retinal locations unused during adaptation. To make the target appear in such "virgin territory," we had it jump first vertically and then 10 degrees horizontally; both jumps were completed and the target spot extinguished before saccades were made sequentially to the remembered target locations. Conventional adaptation decreased the gain of the second, horizontal saccade even though the target was in a nonadapted retinal location. In contrast, the horizontal component of oblique saccades made directly to the same virgin location showed much less gain decrease, suggesting that the adaptation is specific to saccade direction rather than to target location. Thus visual remapping cannot account for the entire reduction of saccadic gain. We conclude that saccadic gain adaptation involves an error signal that is primarily visual, not motor, but that the adaptation itself is primarily motor, not visual.
Blind phase calibration in sparse recovery

We consider a blind calibration problem in a compressed sensing measurement system in which each sensor introduces an unknown phase shift to be determined. We show that this problem can be approached similarly to the problem of phase retrieval from quadratic measurements. Furthermore, when dealing with measurements generated from multiple unknown (but sparse) signals, we extend the approach for phase retrieval to solve the calibration problem in order to recover the signals jointly along with the phase shift parameters. Additionally, we propose an alternative optimization method with less computation complexity and memory requirements. The proposed methods are shown to have significantly better recovery performance than individual recovery of the input signals when the number of input signals is sufficiently large.
Improving Fingerprint Orientation Extraction

Computation of local orientations is a primary step in fingerprint recognition. A large number of approaches have been proposed in the literature, but no systematic quantitative evaluations have been done yet. We implemented and tested several well know methods and a plethora of their variants over a novel, specifically designed, benchmark, made available in the FVC-onGoing framework. We proved that parameter optimizations, pre- and post-processing stages can markedly improve accuracy of the baseline methods on bad quality fingerprints. Finally, in this paper we propose a novel adaptive method which selectively exploits accuracy of local-based analysis and learning-based global methods, thus achieving the overall best performance on a challenging dataset.
Trabecular bone of precocials at birth; Are they prepared to run for the wolf(f)?

Bone is a dynamic tissue adapting to loading according to “Wolff's law of bone adaptation. ” During very early life, however, such a mechanism may not be adequate enough to adapt to the dramatic change in environmental challenges in precocial species. Their neonates are required to stand and walk within hours after birth, in contrast to altricial animals that have much more time to adapt from the intrauterine environment to the outside world. In this study, trabecular bone parameters of the talus and sagittal ridge of the tibia from stillborn but full‐term precocials (calves and foals) were analyzed by micro‐CT imaging in order to identify possible anticipatory mechanisms to loading. Calculated average bone volume fraction in the Shetland pony (49–74%) was significantly higher compared to Warmblood foals (28–51%). Bovine trabecular bone was characterized by a low average bone volume fraction (22–28%), however, more directional anisotropy was found. It is concluded that anticipatory strategies in skeletal development exist in precocial species, which differ per species and are most likely related to anatomical differences in joint geometry and related loading patterns. The underlying regulatory mechanisms are still unknown, but they may be based on a genetic blueprint for the development of bone. More knowledge, both about a possible blueprint and its regulation, will be helpful in understanding developmental bone and joint diseases. J. Morphol. 277:948–956, 2016. © 2016 Wiley Periodicals, Inc.
Spitzer Observations of a 24 μm Shadow: Bok Globule CB 190

We present Spitzer observations of the dark globule CB 190 (LDN 771). We observe a roughly circular 24 μm shadow with a 70'' radius. The extinction profile of this shadow matches the profile derived from 2MASS photometry at the outer edges of the globule and reaches a maximum of ~32 visual magnitudes at the center. The corresponding mass of CB 190 is ~10 M☉. Our 12CO and 13CO J = 2-1 data over a 10′ × 10′ region centered on the shadow show a temperature ~10 K. The thermal continuum indicates a similar temperature for the dust. The molecular data also show evidence of freezeout onto dust grains. We estimate a distance to CB 190 of 400 pc using the spectroscopic parallax of a star associated with the globule. Bonnor-Ebert fits to the density profile, in conjunction with this distance, yield ξmax = 7.2, indicating that CB 190 may be unstable. The high temperature (56 K) of the best-fit Bonnor-Ebert model is in contradiction with the CO and thermal continuum data, leading to the conclusion that the thermal pressure is not enough to prevent free-fall collapse. We also find that the turbulence in the cloud is inadequate to support it. However, the cloud may be supported by the magnetic field, if this field is at the average level for dark globules. Since the magnetic field will eventually leak out through ambipolar diffusion, it is likely that CB 190 is collapsing or in a late precollapse stage.
Towards an ambidextrous government: Strategies for balancing exploration and exploitation in open government

Governments are often putting their efforts in the operation and execution of existing services without having the means to innovate. Ambidexterity is the ability to operate existing services and to innovate at the same time Ambidexterity is a concept originating from organizational studies in the private sector and is hardly used in the public sector. The goal of this paper is to identify strategies used by governments to combine exploitation and exploration. Factors influencing ambidexterity were derived from the literature and categorized in political, organizational, technological and economical categories. These factors were used to analyze two case studies. The cases revealed strategies used by government to move from exploitation to exploration. Strategies include providing incentives, like awards and prizes, to involve resources that are external to the government. The strategies can be classified as contextual ambidexterity.
Brain white matter microstructure is associated with susceptibility to motion‐induced nausea

Nausea is associated with significant morbidity, and there is a wide range in the propensity of individuals to experience nausea. The neural basis of the heterogeneity in nausea susceptibility is poorly understood. Our previous functional magnetic resonance imaging (fMRI) study in healthy adults showed that a visual motion stimulus caused activation in the right MT+/V5 area, and that increased sensation of nausea due to this stimulus was associated with increased activation in the right anterior insula. For the current study, we hypothesized that individual differences in visual motion‐induced nausea are due to microstructural differences in the inferior fronto‐occipital fasciculus (IFOF), the white matter tract connecting the right visual motion processing area (MT+/V5) and right anterior insula. To test this hypothesis, we acquired diffusion tensor imaging data from 30 healthy adults who were subsequently dichotomized into high and low nausea susceptibility groups based on the Motion Sickness Susceptibility Scale. We quantified diffusion along the IFOF for each subject based on axial diffusivity (AD); radial diffusivity (RD), mean diffusivity (MD) and fractional anisotropy (FA), and evaluated between‐group differences in these diffusion metrics. Subjects with high susceptibility to nausea rated significantly (P < 0.001) higher nausea intensity to visual motion stimuli and had significantly (P < 0.05) lower AD and MD along the right IFOF compared to subjects with low susceptibility to nausea. This result suggests that differences in white matter microstructure within tracts connecting visual motion and nausea‐processing brain areas may contribute to nausea susceptibility or may have resulted from an increased history of nausea episodes.