Miracle-dz/UniFAR-FTUs huggingface dataset:
The three-dimensional shapes of underground coal miners’ feet do not match the internal dimensions of their work boots

Abstract Mining work boots provide an interface between the foot and the ground, protecting and supporting miners’ feet during lengthy coal mining shifts. Although underground coal miners report the fit of their work boots as reasonable to good, they frequently rate their boots as uncomfortable, suggesting that there is a mismatch between the shape of their feet and their boots. This study aimed to identify whether dimensions derived from the three-dimensional scans of 208 underground coal miners’ feet (age 38.3 ± 9.8 years) differed from the internal dimensions of their work boots. The results revealed underground coal miners wore boots that were substantially longer than their feet, possibly because boots available in their correct length were too narrow. It is recommended boot manufacturers reassess the algorithms used to create boot lasts, focusing on adjusting boot circumference at the instep and heel relative to increases in foot length. Practitioner Summary: Fit and comfort ratings suggest a mismatch between the shape of underground coal miners’ feet and their boots exists. This study examined whether three-dimensional scans of 208 miners’ feet differed from their boot internal dimensions. Miners wore boots substantially longer than their feet, possibly due to inadequate width.
Asymptotic enumeration and limit laws of planar graphs

A graph is planar if it can be embedded in the plane, or in the sphere, so that no two edges cross at an interior point. A planar graph together with a particular embedding is called a map. There is a rich theory of counting maps, started by Tutte in the 1960's. However, in this paper we are interested in counting graphs as combinatorial objects, regardless of how many nonequivalent topological embeddings they may have. As we are going to see, this makes the counting considerably more difficult.
Assessing Cognitive and Affective Empathy Through the Interpersonal Reactivity Index

One aspect of higher order social cognition is empathy, a psychological construct comprising a cognitive (recognizing emotions) and an affective (responding to emotions) component. The complex nature of empathy complicates the accurate measurement of these components. The most widely used measure of empathy is the Interpersonal Reactivity Index (IRI). However, the factor structure of the IRI as it is predominantly used in the psychological literature differs from Davis’s original four-factor model in that it arbitrarily combines the subscales to form two factors: cognitive and affective empathy. This two-factor model of the IRI, although popular, has yet to be examined for psychometric support. In the current study, we examine, for the first time, the validity of this alternative model. A confirmatory factor analysis showed poor model fit for this two-factor structure. Additional analyses offered support for the original four-factor model, as well as a hierarchical model for the scale. In line with previous findings, females scored higher on the IRI than males. Our findings indicate that the IRI, as it is currently used in the literature, does not accurately measure cognitive and affective empathy and highlight the advantages of using the original four-factor structure of the scale for empathy assessments.
Improving the Outcomes of Organs Obtained From Controlled Donation After Circulatory Death Donors Using Abdominal Normothermic Regional Perfusion

The use of donation after circulatory death (DCD) has increased significantly during the past decade. However, warm ischemia results in a greater risk for transplantation. Indeed, controlled DCD (cDCD) was associated with inferior outcomes compared with donation after brain death. The use of abdominal normothermic regional perfusion (nRP) to restore blood flow before organ recovery in cDCD has been proposed as better than rapid recovery to reverse the effect of ischemia and improve recipients’ outcome. Here, the first Spanish series using abdominal nRP as an in situ conditioning method is reported. A specific methodology to avoid restoring circulation to the brain after death determination is described. Twenty‐seven cDCD donors underwent abdominal nRP during at least 60 min. Thirty‐seven kidneys, 11 livers, six bilateral lungs, and one pancreas were transplanted. The 1‐year death‐censored kidney survival was 91%, and delayed graft function rate was 27%. The 1‐year liver survival rate was 90.1% with no cases of ischemic cholangiopathy. Transplanted lungs and pancreas exhibited primary function. The use of nRP may represent an advance to increase the number and quality of grafts in cDCD. Poor results in cDCD livers could be reversed with nRP. Concerns about restoring brain circulation after death are easily solved.
Immersion Freezing of Total Ambient Aerosols and Ice Residuals

This laboratory study evaluates an experimental set-up to study the immersion freezing properties of ice residuals (IRs) at a temperature ranging from −26 to −34 °C using two continuous-flow diffusion chamber-style ice nucleation chambers coupled with a virtual impactor and heat exchanger. Ice was nucleated on the total ambient aerosol through an immersion freezing mechanism in an ice nucleation chamber (chamber 1). The larger ice crystals formed in chamber 1 were separated and sublimated to obtain IRs, and the frozen fraction of these IRs was investigated in a second ice nucleation chamber (chamber 2). The ambient aerosol was sampled from a sampling site located in the Columbia Plateau region, WA, USA, which is subjected to frequent windblown dust events, and only particles less than 1.5 μm in diameter were investigated. Single-particle elemental composition analyses of the total ambient aerosols showed that the majority of the particles are dust particles coated with organic matter. This study demonstrated a capability to investigate the ice nucleation properties of IRs to better understand the nature of Ice Nucleating Particles (INPs) in the ambient atmosphere.
The World-Wide Web: quagmire or gold mine?

Skeptics believe the Web is too unstructured for Web mining to succeed. Indeed, data mining has been applied traditionally to databases, yet much of the information on the Web lies buried in documents designed for human consumption such as home pages or product catalogs. Furthermore, much of the information on the Web is presented in natural-language text with no machine-readable semantics; HTML annotations structure the display of Web pages, but provide little insight into their content. Some have advocated transforming the Web into a massive layered database to facilitate data mining [12], but the Web is too dynamic and chaotic to be tamed in this manner. Others have attempted to hand code site-specific “wrappers” that facilitate the extraction of information from individual Web resources (e.g., [8]). Hand coding is convenient but cannot keep up with the explosive growth of the Web. As an alternative, this article argues for the structured Web hypothesis: Information on the Web is sufficiently structured to facilitate effective Web mining. Examples of Web structure include linguistic and typographic conventions, HTML annotations (e.g., <title>), classes of semi-structured documents (e.g., product catalogs), Web indices and directories, and much more. To support the structured Web hypothesis, this article will survey preliminary Web mining successes and suggest directions for future work. Web mining may be organized into the following subtasks:
A prospective randomized study comparing radiofrequency ablation and hepatic resection for hepatocellular carcinoma

Purpose Although there are several prospective clinical studies comparing radiofrequency ablation (RFA) and hepatic resection (HR) for the treatment of hepatocellular carcinoma, there are few trials that have been performed in strictly homogeneous patients. Methods Patients who were newly diagnosed with a solitary hepatocellular carcinoma were randomized to the HR or RFA group. Inclusion criteria were as follows: age ≥ 20 years but ≤ 70 years, Child-Pugh class A, maximal diameter of the tumor ≥ 2 cm but ≤ 4 cm, no previous treatment history, and platelet count > 80,000/mm3. Results Although the study was early terminated, 29 and 34 patients were enrolled in the HR and RFA groups, respectively, and prospectively followed on an intention-to-treat basis. The 5-year overall survival rates were 83.4% and 86.2% in the HR and RFA groups, respectively, which were not significantly different (P = 0.812 by log-rank, P = 0.990 by Breslow). The 3- and 5-year disease-free survival rates in the HR group were significantly superior to those in the RFA group (66.7%, 44.4% vs. 44.1%, 31.2%, P = 0.071 by log-rank, P = 0.023 by Breslow). Intrahepatic local recurrence tended to develop more frequently in the RFA group (P = 0.042), while the frequency of intrahepatic distant and extrahepatic recurrence was similar bet ween the 2 groups. There were no significant differences in the frequency and severity of complications between the 2 groups. Conclusion HR was significantly superior to RFA in terms of disease-free survival; however, the overall survival was excellent in both groups.
An inquiry into the nature and causes of the wealth of internet miscreants

This paper studies an active underground economy which specializes in the commoditization of activities such as credit car d fraud, identity theft, spamming, phishing, online credential the ft, and the sale of compromised hosts. Using a seven month trace of logs collected from an active underground market operating on public Internet chat networks, we measure how the shift from “hacking for fun” to “hacking for profit” has given birth to a societal subs trate mature enough to steal wealth into the millions of dollars in less than one year.
The Price of Fame: The Impact of Stimulus Familiarity on Proactive Interference Resolution

Interference from previously learned information, known as proactive interference (PI), limits our memory retrieval abilities. Previous studies of PI resolution have focused on the role of short-term familiarity, or recency, in causing PI. In the present study, we investigated the impact of long-term stimulus familiarity on PI resolution processes. In two behavioral experiments and one event-related fMRI experiment, long-term familiarity was manipulated through the use of famous and nonfamous stimuli, and short-term familiarity was manipulated through the use of recent and nonrecent probe items in an item recognition task. The right middle frontal gyrus demonstrated greater sensitivity to famous stimuli, suggesting that long-term stimulus familiarity plays a role in influencing PI resolution processes. Further examination of the effect of long-term stimulus familiarity on PI resolution revealed a larger behavioral interference effect for famous stimuli, but only under speeded response conditions. Thus, models of memory retrieval—and of the cognitive control mechanisms that guide retrieval processes—should consider the impact of and interactions among sources of familiarity on multiple time scales.
Impacts of invading alien plant species on water flows at stand and catchment scales

The impacts of invasions by alien plant species on the quantity of rainwater that reaches rivers and streams have been studied in several countries. Some studies have found that there is a large impact and others have found little or no impact. These conflicting conclusions can be explained largely by differences in the structure (e.g. height, depth of root systems) and the physiology (e.g. evergreen, deciduous, water stress tolerance) between the alien and the indigenous plant species. The greater the differences between the two, the greater the impact is likely to be.
Resistive Cerebral Blood Flow as a Potential Marker of Subclinical Brain Damage in Essential Hypertension

Introduction: Subclinical brain damage in essential hypertension is more prevalent than cardiovascular or renal impairment; nevertheless, screening for nervous system involvement is difficult due to the low accessibility and high costs of these techniques. Objective: To assess the frequency of silent target organ damage in a cohort of asymptomatic hypertensive patients and to evaluate the potential usefulness of carotid ultrasonographic (US) variables as predictors of subclinical brain damage. Patients and Methods: Thirty four neurologically asymptomatic subjects (mean age 59 years) with essential hypertension were included. Target organ damage was evaluated: degree of hypertensive retinopathy, heart, kidney and brain. Structural and hemodynamical carotid Doppler US parameters were also investigated. Results: The brain was the most frequently affected target organ (70.6%), followed by the heart (67.9%) and kidney (58.6%). Carotid US parameters showed no association of intima media thickness with brain MRI results; nevertheless, decreased diastolic flow velocity and increased resistive index pointed to a resistive carotid flow pattern in patients with classical brain MRI lesions and predicted subclinical lesions with a sensitivity of 70% and 74% and a specificity of 72% and 80% respectively. Conclusions: This study supports previous findings that place the brain as the most frequently affected target organ in essential hypertensive patients and sheds more light on the potential usefulness of carotid structure and hemodynamics as imaging biomarkers of subclinical brain lesions.
Sign rank versus Vapnik-Chervonenkis dimension

This work studies the maximum possible sign rank of sign -matrices with a given Vapnik-Chervonenkis dimension . For , this maximum is three. For , this maximum is . For 2}$? >, similar but slightly less accurate statements hold. The lower bounds improve on previous ones by Ben-David et al., and the upper bounds are novel. The lower bounds are obtained by probabilistic constructions, using a theorem of Warren in real algebraic topology. The upper bounds are obtained using a result of Welzl about spanning trees with low stabbing number, and using the moment curve. The upper bound technique is also used to: (i) provide estimates on the number of classes of a given Vapnik-Chervonenkis dimension, and the number of maximum classes of a given Vapnik-Chervonenkis dimension — answering a question of Frankl from 1989, and (ii) design an efficient algorithm that provides an multiplicative approximation for the sign rank. We also observe a general connection between sign rank and spectral gaps which is based on Forster's argument. Consider the adjacency - matrix of a -regular graph with a second eigenvalue of absolute value and . We show that the sign rank of the signed version of this matrix is at least . We use this connection to prove the existence of a maximum class with Vapnik-Chervonenkis dimension and sign rank . This answers a question of Ben-David et al. regarding the sign rank of large Vapnik-Chervonenkis classes. We also describe limitations of this approach, in the spirit of the Alon-Boppana theorem. We further describe connections to communication complexity, geometry, learning theory, and combinatorics. Bibliography: 69 titles.
Honor Thy Parents

The present study explores patterns of parity and disparity in the effect of filial responsibility on health-related evaluations and caregiving decisions. Participants who identified as White, Black, Hispanic, or Asian/Pacific Islander read a vignette about an older man needing medical care. They were asked to imagine that they were the man’s son and answer questions regarding their likelihood of hiring a health care advocate (HCA) for services related to the father’s care. A multigroup (ethnicity) path analysis was performed, and an intercept invariant multigroup model fits the data best. Direct and indirect effect estimation showed that filial responsibility mediated the relationship between both the perceived severity of the father’s medical condition and the perceived need for medical assistance and the likelihood of hiring an HCA only for White and Hispanic participants, albeit differently. The findings demonstrate that culture and ethnicity affect health evaluations and caregiving decision making.
Plasma Circulating Tumor DNA Levels for the Monitoring of Melanoma Patients: Landscape of Available Technologies and Clinical Applications

Melanoma is a cutaneous cancer with an increasing worldwide prevalence and high mortality due to unresectable or metastatic stages. Mutations in BRAF, NRAS, or KIT are present in more than 60% of melanoma cases, but a useful blood-based biomarker for the clinical monitoring of melanoma patients is still lacking. Thus, the analysis of circulating tumor cells (CTCs) and/or cell-free circulating tumor DNA (ctDNA) analysis from blood (liquid biopsies) appears to be a promising noninvasive, repeatable, and systemic sampling tool for detecting and monitoring melanoma. Here, we review the molecular biology-based strategies used for ctDNA quantification in melanoma patients, as well as their main clinical applications. Droplet digital PCR (ddPCR) and next generation sequencing (NGS) technologies appear to be two versatile and complementary strategies to study rare variant mutations for the detection and monitoring of melanoma progression. Among the different clinical uses of ctDNA, we highlight the assessment of molecular heterogeneity and the identification of genetic determinants for targeted therapy as well as the analysis of acquired resistance. Importantly, ctDNA quantification might also be a novel biomarker with a prognostic value for melanoma patients.
deep-orange and carnation define distinct stages in late endosomal biogenesis in Drosophila melanogaster

Endosomal degradation is severely impaired in primary hemocytes from larvae of eye color mutants of Drosophila. Using high resolution imaging and immunofluorescence microscopy in these cells, products of eye color genes, deep-orange (dor) and carnation (car), are localized to large multivesicular Rab7-positive late endosomes containing Golgi-derived enzymes. These structures mature into small sized Dor-negative, Car-positive structures, which subsequently fuse to form tubular lysosomes. Defective endosomal degradation in mutant alleles of dor results from a failure of Golgi-derived vesicles to fuse with morphologically arrested Rab7-positive large sized endosomes, which are, however, normally acidified and mature with wild-type kinetics. This locates the site of Dor function to fusion of Golgi-derived vesicles with the large Rab7-positive endocytic compartments. In contrast, endosomal degradation is not considerably affected in car 1 mutant; fusion of Golgi-derived vesicles and maturation of large sized endosomes is normal. However, removal of Dor from small sized Car-positive endosomes is slowed, and subsequent fusion with tubular lysosomes is abolished. Overexpression of Dor in car 1 mutant aggravates this defect, implicating Car in the removal of Dor from endosomes. This suggests that, in addition to an independent role in fusion with tubular lysosomes, the Sec1p homologue, Car, regulates Dor function.
Mapping Affinities in Academic Organizations

Scholarly affinities are one of the most fundamental hidden dynamics that drive scientific development. Some affinities are actual, and consequently can be measured through classical academic metrics such as co-authoring. Other affinities are potential, and therefore do not leave visible traces in information systems; for instance, some peers may share interests without actually knowing it. This article illustrates the development of a map of affinities for academic collectives, designed to be relevant to three audiences: the management, the scholars themselves, and the external public. Our case study involves the School of Architecture, Civil and Environmental Engineering of EPFL, hereinafter ENAC. The school consists of around one thousand scholars, seventy laboratories, and three institutes. The actual affinities are modeled using the data available from the information systems reporting publications, teaching, and advising scholars, whereas the potential affinities are addressed through text mining of the publications. The major challenge for designing such a map is to represent the multi-dimensionality and multi-scale nature of the information. The affinities are not limited to the computation of heterogeneous sources of information; they also apply at different scales. The map thus shows local affinities inside a given laboratory, as well as global affinities among laboratories. This article presents a graphical grammar to represent affinities. Its effectiveness is illustrated by two actualizations of the design proposal: an interactive online system in which the map can be parameterized, and a large-scale carpet of 250 square meters. In both cases, we discuss how the materiality influences the representation of data, in particular the way key questions could be appropriately addressed considering the three target audiences: the insights gained by the management and their consequences in terms of governance, the understanding of the scholars’ own positioning in the academic group in order to foster opportunities for new collaborations and, eventually, the interpretation of the structure from a general public to evaluate the relevance of the tool for external communication.
Correlation between stage shift and differences in mortality in the European Randomised study of Screening for Prostate Cancer (ERSPC)

mortality in the European Randomised study of Screening for Prostate Cancer (ERSPC) Leonard P. Bokhorst*, Marco Zappa, Sigrid V. Carlsson, Maciej Kwiatkowski, Louis Denis**, Alvaro Paez, Jonas Hugosson, Sue Moss, Anssi Auvinen and Monique J. Roobol* *Department of Urology, Erasmus University Medical Center, Rotterdam, The Netherlands, Unit of Clinical and Descriptive Epidemiology, ISPO, Florence, Italy, Department of Surgery (Urology Service), Memorial Sloan Kettering Cancer Center, New York, USA, Institute of Clinical Sciences, Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden, Department of Urology, Kantonsspital Aarau, Aarau, Switzerland, **Oncology Centre Antwerp, Antwerp, Belgium, Department of Urology, Hospital Universitario de Fuenlabrada, Madrid, Spain, Department of Urology, Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden, Centre for Cancer Prevention, Queen Mary University of London, London, UK, and School of Health Sciences, University of Tampere, Tampere, Finland
Simultaneous use of erythropoietin and LFM‐A13 as a new therapeutic approach for colorectal cancer

Bruton's tyrosine kinase (Btk) is a non‐receptor tyrosine kinase involved in the activation of signalling pathways responsible for cell maturation and viability. Btk has previously been reported to be overexpressed in colon cancers. This kind of cancer is often accompanied by anaemia, which is treated with an erythropoietin supplement. The goal of the present study was to assess the effects of combination therapy with erythropoietin β (Epo) and LFM‐A13 (Btk inhibitor) on colon cancer in in vitro and in vivo models.
Can consultation skills training change doctors' behaviour to increase involvement of patients in making decisions about standard treatment and clinical trials: a randomized controlled trial

Informed consent is required for both standard cancer treatments and experimental cancer treatments in a clinical trial. Effective and sensitive physician–patient communication about informed consent is difficult to achieve. Our aim was to train doctors in clear, collaborative and ethical communication about informed consent and evaluate the impact of training on doctor behaviour, stress and satisfaction.