Miracle-dz/UniFAR-FTUs huggingface dataset:
Viral Outbreak in Corals Associated with an In Situ Bleaching Event: Atypical Herpes-Like Viruses and a New Megavirus Infecting Symbiodinium

Previous studies of coral viruses have employed either microscopy or metagenomics, but few have attempted to comprehensively link the presence of a virus-like particle (VLP) to a genomic sequence. We conducted transmission electron microscopy imaging and virome analysis in tandem to characterize the most conspicuous viral types found within the dominant Pacific reef-building coral genus Acropora. Collections for this study inadvertently captured what we interpret as a natural outbreak of viral infection driven by aerial exposure of the reef flat coincident with heavy rainfall and concomitant mass bleaching. All experimental corals in this study had high titers of viral particles. Three of the dominant VLPs identified were observed in all tissue layers and budding out from the epidermis, including viruses that were ∼70, ∼120, and ∼150 nm in diameter; these VLPs all contained electron dense cores. These morphological traits are reminiscent of retroviruses, herpesviruses, and nucleocytoplasmic large DNA viruses (NCLDVs), respectively. Some 300–500 nm megavirus-like VLPs also were observed within and associated with dinoflagellate algal endosymbiont (Symbiodinium) cells. Abundant sequence similarities to a gammaretrovirus, herpesviruses, and members of the NCLDVs, based on a virome generated from five Acropora aspera colonies, corroborated these morphology-based identifications. Additionally sequence similarities to two diagnostic genes, a MutS and (based on re-annotation of sequences from another study) a DNA polymerase B gene, most closely resembled Pyramimonas orientalis virus, demonstrating the association of a cosmopolitan megavirus with Symbiodinium. We also identified several other virus-like particles in host tissues, along with sequences phylogenetically similar to circoviruses, phages, and filamentous viruses. This study suggests that viral outbreaks may be a common but previously undocumented component of natural bleaching events, particularly following repeated episodes of multiple environmental stressors.
Factors Affecting The Spiritual Well-being of Foreign Immigrant Wives in Korea

The purpose of this study was to identify the influencing factors that affect spiritual well-being of foreign immigrant women in Korea. Research design is descriptive survey study. The participants of this research were foreign immigrant women married to Korean men residing in the 5 cities, S, KG(H, Y), KN(J) and P. Structured questionnaire was used to verify the degree of spiritual well-being and acculturative stress level. Data were collected from August 2010 to May 2011 and were analyzed by SPSS. As a result, the mean score of spiritual well-being was 3.31±. 48. Some of the variables studied prior to the research were , satisfaction of marriage life, life quality in Korea, acculturative stress level, duration of stay in Korea, degree of education and religion were the major factors that affected the spiritual well-being of the foreign immigrant wives. In order to increase the level of their spiritual well-being, the immigrant wives should be able to practice their religion of choice, and increasing the effectiveness of communication through various methods, such as Korean language education and learning the wives’ languages, would also help raise the level of marriage life satisfaction. More effort to develop other intercession methods should be made.
Variable-based ε — PAES with adaptive fertility rate

This paper suggests a new multi-objective evolutionary algorithm. The proposed ε-PAES combines ideas from two well-known algorithms, namely PAES and ε-MOEA. The adopted ideas are accompanied with a front-based adaptive fertility-rate and a variable-based approach. The algorithm performs the optimization process using separated local searches per each one of the problem's decision variables, by adaptation of the associated step sizes. The performance of the algorithm is checked on several test cases and is statistically compared with the performance of ε-MOEA. It is found that the proposed algorithm achieves results of similar quality to ε-MOEA while consuming less computational resources.
Education Choices and Migration Prospects Among Youth in the Philippines

This paper provides a preliminary investigation of the education, migration, and employment preferences of the youth. It employs primary data consisting of the responses of 280 high school students to a specialized survey instrument. The paper places particular emphasis on identifying and measuring the impact of familial and social networks on the prospective education and migration decisions of the youth. The data suggest that a markedly smaller proportion of the youth are inclined to pursue courses in the hard sciences as compared to more popular courses such as engineering, accountancy, business, and economics. The results gleaned from the data suggest that there could be a gender bias in prospective migration. The results also suggest that familial networks strongly influence the sentiments of the youth towards migration.
Agents, Intelligence, and Social Atoms

One of the fastest-rising keywords in the physics literature is “social”. Literally thousands of papers in physics are devoted to modeling social systems, and indeed regular sections of leading journals such as Physica A and Physical Review E are devoted to this topic. The analogy between people and particles has been so consistent that a recent popular review was appropriately titled The Social Atom (Buchanan 2007).
Electromyographic Analysis of Hip and Knee Musculature During Running

The purpose of this study was to describe the firing pat tern of 11 hip and knee muscles during running. Thirty recreational runners volunteered to run at 3 different paces with indwelling electromyographic electrodes while being filmed at 100 frames per second. Results demonstrated that medial and lateral vasti muscles acted together for knee extension during terminal swing and loading response, possibly providing a patella sta bilizing role. The vastus intermedius muscle functioned with the other vasti, plus eccentrically controlled knee flexion during swing phase. The rectus femoris muscle fired with the vastus intermedius muscle and assisted the iliacus muscle with hip flexion. The hamstrings fired primarily to eccentrically control hip flexion. The adduc tor magnus, tensor fascia lata, and gluteus maximus muscles afforded pelvic stabilization while assisting with hip flexion and extension. Forward propulsion was provided mainly by hip flexion and knee extension, which is contrary to the view that posterior calf muscles provide propulsion during toe off. Faster running paces lead to increased activity in the muscles. This may lead to more injuries, primarily in the muscles that were con tracting eccentrically.
The Rise of China and India: Blessing or Curse for the Advanced Countries?

This paper evaluates the impact of the rise of large emerging manufacturing exporters such as China and India on economic growth in advanced countries. After illustrating the possible theoretical channels, I estimate a growth regression based on 3-year average data augmented with country-specific measures of import and export competition from China and India using instrumental variables. Stronger import competition from China and India leads to stronger income growth in advanced countries, but to a loss of manufacturing jobs. A more flexible labour market, lower concentration of employment in manufacturing and pre-existing trade links with China and India help advanced countries to maximise the growth dividend resulting from their rise in world export markets. JEL Classification: F02, F15
The efficacy and safety of postoperative adjuvant transarterial embolization and radiotherapy in hepatocellular carcinoma patients with portal vein tumor thrombus

Objective This study aims to find out the safety and efficiency of postoperative adjuvant transarterial chemoembolization (TACE) and radiotherapy (RT) in hepatocellular carcinoma (HCC) patients with portal vein tumor thrombus (PVTT). Methods From 2009 to 2010, a total of 92 HCC patients with PVTT were enrolled in this retrospective study. Patients were divided into three groups according to their adjuvant therapies (conservative group, n=51; TACE group, n=31; RT group, n=10). Results In our analysis, median survival in patients with postoperative adjuvant TACE (21.91±3.60 months) or RT (14.53±1.61 months) was significantly longer than patients with hepatectomy alone (8.99±1.03 months). But the difference between adjuvant TACE and RT was of no significance (P=0.716). Also a similar result could be observed in median disease-free survival: conservative group (6.51±1.44 months), TACE group (13.98±3.38 months), and RT group (14.03±2.40 months). Treatment strategies (hazard ratio [HR] =0.411, P<0.001) and PVTT type (HR =4.636, P<0.001) were the independent prognostic factors for overall survival. Similarly, the risk factors were the same when multivariate analysis was conducted in disease-free survival (treatment strategies, HR =0.423, P<0.001; PVTT type, HR =4.351, P<0.001) and recurrence (treatment strategies, HR =0.459, P=0.030; PVTT type, HR =2.908, P=0.047). Patients with PVTT type I had longer overall survival than patients with PVTT type II (median survival: 18.43±2.88 months vs 11.59±1.45 months, P=0.035). Conclusion Postoperative adjuvant TACE and RT may be a choice for HCC patients with PVTT.
Distribution and habitat segregation on different spatial scales among diploid, tetraploid and hexaploid cytotypes of Senecio carniolicus (Asteraceae) in the Eastern Alps

Background and Aims The spatial distribution of cytotypes can provide valuable insights into evolutionary patterns of polyploid complexes. In a previous study the macro-scale distribution of the three main cytotypes in Senecio carniolicus (Asteraceae) within the Eastern Alps was characterized. Employing a roughly 12-fold extended sampling, the present study focuses on unravelling patterns of cytotype distribution on the meso- and microscale and on correlating those with ecological properties of the growing sites. Methods DAPI flow cytometry of dried samples was used to determine DNA ploidy level in 5033 individuals from 100 populations spread over the entire Eastern Alpine distribution area of S. carniolicus. Descriptors of microhabitats as well as spatial data were recorded in the field, and analysed with a mixed-effects ANOVA. Key Results Extensive variation in DNA ploidy levels (2x, 3x, 4x, 5x, 6x, 7x, 8x, 9x) was detected. Of the main cytotypes, diploids and hexaploids were widespread and had strongly overlapping distributions resulting in the frequent occurrence of cytotype mixtures (half of the investigated populations), whereas tetraploids were disjunctly distributed and occurred in the south-west and the east of the species' distribution area. In spite of the frequent co-occurrence of cytotypes, only 1 % of the samples belonged to secondary cytotypes (3x, 5x, 7x, 8x, 9x). Diploids, tetraploids and hexaploids were altitudinally segregated, but with broad overlap. Similarly, highly significant differences in vegetation and rock cover as well as microhabitat exposure were found between the main cytotypes. Conclusions Senecio carniolicus shows a remarkable diversity of cytotypes. The distribution of the three main cytotypes (2x, 4x, 6x) has been shaped by Pleistocene glaciations to different extents. Whereas tetraploids are nearly entirely restricted to refugia, hexaploids colonized areas that were extensively glaciated. Diploid and hexaploid individuals often co-occur in mixed populations, where they are spatially and ecologically segregated at both the meso-scale (altitudinal differentiation, exposure of the growing site) and the micro-scale (cover of vegetation and bare rock). With regard to the ecological parameters investigated, the tetraploid cytotype occupies an intermediate position. The rareness of secondary cytotypes suggests the presence of strong pre- or post-zygotic mating barriers.
Detailed Analysis of Focal Chromosome Arm 1q and 6p Amplifications in Urothelial Carcinoma Reveals Complex Genomic Events on 1q, and SOX4 as a Possible Auxiliary Target on 6p

Background Urothelial carcinoma shows frequent amplifications at 6p22 and 1q21–24. The main target gene at 6p22 is believed to be E2F3, frequently co-amplified with CDKAL1 and SOX4. There are however reports on 6p22 amplifications that do not include E2F3. Previous analyses have identified frequent aberrations occurring at 1q21–24. However, due to complex rearrangements it has been difficult to identify specific 1q21–24 target regions and genes. Methods We selected 29 cases with 6p and 37 cases with 1q focal genomic amplifications from 261 cases of urothelial carcinoma analyzed by array-CGH for high resolution zoom-in oligonucleotide array analyses. Genomic analyses were combined with gene expression data and genomic sequence analyses to characterize and fine map 6p22 and 1q21–24 amplifications. Results We show that the most frequently amplified gene at 6p22 is SOX4 and that SOX4 can be amplified and overexpressed without the E2F3 or CDKAL1 genes being included in the amplicon. Hence, our data point to SOX4 as an auxiliary amplification target at 6p22. We further show that at least three amplified regions are observed at 1q21–24. Copy number data, combined with gene expression data, highlighted BCL9 and CHD1L as possible targets in the most proximal region and MCL1, SETDB1, and HIF1B as putative targets in the middle region, whereas no obvious targets could be determined in the most distal amplicon. We highlight enrichment of G4 quadruplex sequence motifs and a high number of intraregional sequence duplications, both known to contribute to genomic instability, as prominent features of the 1q21–24 region. Conclusions Our detailed analyses of the 6p22 amplicon suggest SOX4 as an auxiliary target gene for amplification. We further demonstrate three separate target regions for amplification at 1q21–24 and identified BCL9, CHD1L, and MCL1, SETDB1, and HIF1B as putative target genes within these regions.
Lithologic influences on groundwater recharge through incised glacial till from profile to regional scales: Evidence from glaciated Eastern Nebraska

Variability in sediment hydraulic properties associated with landscape depositional and erosional features can influence groundwater recharge processes by affecting soil‐water storage and transmission. This study considers recharge to aquifers underlying river‐incised glaciated terrain where the distribution of clay‐rich till is largely intact in upland locations but has been removed by alluvial erosion in stream valleys. In a stream‐dissected glacial region in eastern Nebraska (Great Plains region of the United States), recharge estimates were developed for nested profile, aquifer, and regional scales using unsaturated zone profile measurements (matric potentials, Cl− and 3H), groundwater tracers (CFC‐12 and SF6), and a remote sensing‐assisted water balance model. Results show a consistent influence of till lithology on recharge rates across nested spatial scales despite substantial uncertainty in all recharge estimation methods, suggesting that minimal diffuse recharge occurs through upland glacial till lithology whereas diffuse recharge occurs in river valleys where till is locally absent. Diffuse recharge is estimated to account for a maximum of 61% of total recharge based on comparison of diffuse recharge estimated from the unsaturated zone (0–43 mm yr−1) and total recharge estimated from groundwater tracers (median 58 mm yr−1) and water balance modeling (median 56 mm yr−1). The results underscore the importance of lithologic controls on the distributions of both recharge rates and mechanisms.
Recent Emergence of Staphylococcus aureus Clonal Complex 398 in Human Blood Cultures

Background Recently, a clone of MRSA with clonal complex 398 (CC398) has emerged that is related to an extensive reservoir in animals, especially pigs and veal calves. It has been reported previously that methicillin-susceptible variants of CC398 circulate among humans at low frequency, and these have been isolated in a few cases of bloodstream infections (BSI). The purpose of this study was to determine the prevalence of S. aureus CC398 in blood cultures taken from patients in a geographic area with a high density of pigs. Methodology/Principal Findings In total, 612 consecutive episodes of S. aureus BSI diagnosed before and during the emergence of CC398 were included. Three strains (2 MSSA and 1 MRSA) that were isolated from bacteremic patients between 2010–2011 were positive in a CC398 specific PCR. There was a marked increase in prevalence of S. aureus CC398 BSI isolated between 2010–2011 compared to the combined collections that were isolated between 1996–1998 and 2002–2005 (3/157, 1.9% vs. 0/455, 0.0%; p = 0.017). Conclusions/Significance In conclusion, in an area with a relative high density of pigs, S. aureus CC398 was found as a cause of BSI in humans only recently. This indicates that S. aureus CC398 is able to cause invasive infections in humans and that the prevalence is rising. Careful monitoring of the evolution and epidemiology of S. aureus CC398 in animals and humans is therefore important.
Do Small Firms Benefit from Auditor Attestation of Internal Control Effectiveness

SUMMARY: While auditor attestation of the effectiveness of internal control over financial reporting (ICFR) is required for firms with a public float of at least $75 million (accelerated filers), the Securities and Exchange Commission (SEC) has delayed auditor attestation for non-accelerated filers several times. The Dodd-Frank Act of 2010 exempts non-accelerated filers from auditor attestation. We examine the relation between auditor attestation and revenue quality for a sample of non-accelerated filers and small accelerated filers. We find that discretionary (abnormal) revenues, our proxy for revenue quality, are lower by about 1.5 percent of total assets for accelerated filers relative to non-accelerated filers. This finding holds even among firms whose management has certified their ICFR to be effective. Overall, the findings support the notion that auditor attestation of the effectiveness of ICFR benefits small accelerated filers via higher revenue quality. We believe our findings are timely and pote.
Clinical, radiographic and functional effectiveness of tocilizumab for rheumatoid arthritis patients—REACTION 52-week study

Objectives. To evaluate the effectiveness and safety of tocilizumab in RA patients in clinical practice. Methods. We observed 232 consecutive RA patients who began tocilizumab in three rheumatology centres in Japan for 52 weeks. Clinical, radiographic and functional status and safety were evaluated. Results. Mean age of the 232 patients was 59.1 years, mean duration of disease was 12.4 years and average DAS using the 28-joint count (DAS-28) was 5.6. Although 62.8% of the patients had been treated previously with anti-TNF biologics, clinical remission at Week 52 was achieved in 43.7%, radiographic non-progression in 62.8% and functional remission in 26.4%. Retention rate at Week 52 was 71.1%, and the same for those with or without previous anti-TNF treatment. Adverse drug reactions leading to tocilizumab discontinuation were observed in 15.5% of patients, the most frequent adverse drug reaction being pneumonia in eight cases. On multivariate logistic regression analysis, DAS-28, HAQ-disability index (HAQ-DI), concomitant MTX and concomitant glucocorticoids (GCs) were predictive variables for clinical remission at Week 52 of tocilizumab treatment. In particular, HAQ-DI was found to be a predictive variable for remission of all three types—clinical, radiographic and functional—at Week 52 of tocilizumab treatment. Conclusions. In daily clinical practice, tocilizumab exhibited excellent effectiveness in established RA patients, some of whom had failed to respond to previous anti-TNF treatment. Although further detailed safety findings are required, this study provides valuable real-world findings on the management of RA with tocilizumab.
Collaborative experience and alliance performance: The mediating role of market orientation

Alliances are increasingly becoming common in all business relationships. In particular, alliances that facilitate the sharing of information between alliance partners as a result of collaborative experience is increasing in importance. Market orientation is a construct that can mediate the relationship between a firm’s collaborative experience and their alliance performance. This paper examines this relationship and highlights the importance of market orientation in the alliance context. The core finding is that market orientation is a useful way to examine the information processing behaviours of firms in alliance relationships.
Does Rumination Have Adverse Interpersonal Consequences? A Test of an Emotion-Dysregulation Extension to Stress-Generation Theory in Depression

by Ryan Patrick Egan Stress-generation theory posits that depressed individuals behave in ways that cause stress in their relationships, reducing the quality of social support available to them and thereby maintaining their symptoms. The present study proposes an extension to the existing stress-generation framework to include emotion dysregulation as a precursor to interpersonal stress. In a sample of 135 pairs of same-sex friends, I conducted an experimental test of two predictions: first, that individuals induced to ruminate will be rated poorer in interpersonal functioning during a discussion with a friend than individuals induced to distract themselves; and second, that friends will ruminate more during discussions with individuals induced to ruminate versus distract themselves. These predictions could not be tested adequately due to failure of the emotion-regulation manipulation to produce differential levels of negative mood. Exploratory analyses revealed that higher state rumination predicted lower subsequent state rumination in friends.
The Positive Role of Overconfidence and Optimism in Investment Policy

A semiconductor device includes a predetermined number of surface mount first lead pins (14), arranged around the periphery of the underside of a package (13) fitted with a chip (11). A predetermined number of second lead pins (22, 41), each having a specific function, are provided in a region near the center of the underside of the package (13) inside of the region populated with the first lead pins (14).