Miracle-dz/UniFAR-FTUs huggingface dataset:
Shared Learning for Doctors and Social Workers: Evaluation of a Programme

This paper reports a shared learning programme for final year social work and medical students which was designed in the light of social psychological studies of intergroup behaviour (the Contact Hypothesis). Key features included institutional support for the programme and opportunities to work as equals in pairs and small groups on shared tasks in a co-operative atmosphere. Topics included alcohol abuse, dealing with psychiatric emergencies, deliberate self-harm and community services for people with learning disabilities. A comprehensive evaluation of the effects of the programme on one cohort of 85 participants revealed that overall attitudes towards the other profession had improved and that each saw the other as more professionally competent at the end of the programme. Participants reported increased knowledge of the attitudes, skills, roles and duties of the other profession and of how to work together more effectively.
Aging, social capital, and health care utilization in Canada

Abstract This paper examines relationships between aging, social capital, and healthcare utilization. Cross-sectional data from the 2001 Canadian Community Health Survey and the Canadian Census are used to estimate a two-part model for both GP physicians (visits) and hospitalization (annual nights) focusing on the impact of community- (CSC) and individual-level social capital (ISC). Quantile regressions were also performed for GP visits. CSC is measured using the Petris Social Capital Index (PSCI) based on employment levels in religious and community-based organizations [NAICS 813XX] and ISC is based on self-reported connectedness to community. A higher CSC/lower ISC is associated with a lower propensity for GP visits/higher propensity for hospital utilization among seniors. The part-two (intensity model) results indicated that a one standard deviation increase (0.13%) in the PSCI index leads to an overall 5% decrease in GP visits and an annual offset in Canada of approximately $225 M. The ISC impact was smaller; however, neither measure was significant in the hospital intensity models. ISC mainly impacted the lower quantiles in which there was a positive association with GP utilization, while the impact of CSC was strongest in the middle quantiles. Each form of social capital likely operates through a different mechanism: ISC perhaps serves an enabling role by improving access (e.g. transportation services), while CSC serves to obviate some physician visits that may involve counseling/caring services most important to seniors. Policy implications of these results are discussed herein. How selfish soever man may be supposed, there are evidently some principles in his nature, which interest him in the fortune of others, and render their happiness necessary to him, though he derives nothing from it, except the pleasure of seeing it. … That we often derive sorrow from the sorrow of others, is a matter of fact too obvious to require any instances to prove it; for this sentiment, like all other original passions of human nature, is by no means confined to the virtuous and humane, though they perhaps may feel it with the most exquisite sensibility. The greatest ruffian, the most hardened violator of the laws of society, is not altogether without it. Adam Smith, The Theory of Moral Sentiments, Chapter 1, Part first.
Educational Leadership and the Crisis of Democratic Government

This article is organized around three major assumptions. First, it argues that the current crisis of American schooling is symptomatic of a broader crisis in the meaning and practice of American democracy. Second, it contends that the dominant approaches to educational reform, particularly America 2000, appear to be at odds with educating students to be informed, critical citizens capable of actively participating in shaping and governing a democratic society. Third, it calls for educators to refashion educational leadership through a language of critique and possibility that expands and deepens the possibility for cultural and political democracy. In short, the article suggests that educational reformers need to expand the purpose and promise of schooling beyond the narrow interests of the marketplace, view multicultural education as central to living in a democratic society, refuse to equate nationalism with monoculturalism, and substitute the language of community, solidarity, and public responsibility for the current emphasis on choice and individual competitiveness.
The Way Students Learn: Acquiring Knowledge from an Integrated Science and Social Studies Unit

This article explores, through an analysis of 5 students' experiences in an integrated science and social studies unit on Antarctica, how the students acquired new knowledge. It looks at how new knowledge was constructed from prior knowledge and how prior knowledge was shaped by new knowledge. This is done through examples of 3 types of learning. The first example describes the way students represented and integrated new experiences in working memory using a model of the learning process designed to predict what students will learn and remember from their classroom experiences. The second example develops this model by exploring how the acquisition of specific information shaped students' understanding of larger curriculum topics. In the third example, the role of inference and implicit knowledge is illustrated through an analysis of how students acquired knowledge in the absence of relevant resources or experiences. These examples are also used to explain how different students learned different things from the same classroom activities and how different classroom activities created different learning processes. Implications for the design of more effective classroom tasks and activities are described.
Organizational Control and Work Effort – Another Look at the Interplay of Rewards and Motivation

Providing rewards is a central element of organizational control systems. However, the literature is hardly helpful from a practitioner's perspective: it typically focuses on monetary rewards at the expense of non-monetary, affiliative rewards, and yet researchers disagree over the usefulness of the prior ones. Some scholars claim that monetary rewards merely replace task-related (‘intrinsic’) motivation by reward-induced external pressure (‘extrinsic’ motivation). Empirical findings are mixed, partially given the different conceptualizations of intrinsic motivation. We shed more light on the impact of both monetary and non-monetary, affiliative rewards on the willingness to exert work effort and a potential detrimental interaction with different forms of intrinsic motivation. Our experimental results suggest that monetary and affiliative rewards have different effects: affiliative rewards clearly have beneficial effects, whereas the picture for monetary rewards is more nuanced than typically assumed in literature.
Expression of PAX8 in Normal and Neoplastic Tissues: A Comprehensive Immunohistochemical Study

PAX8 is a nephric-lineage transcription factor and is a crucial transcription factor for organogenesis of the thyroid gland, kidney, and Müllerian system. PAX8 is shown to be expressed in a high percentage of kidney and ovarian carcinomas. Limited information is known about the specificity of PAX8 in various neoplastic tumors. This comprehensive study examines the immuno-histochemical expression of PAX8 in multiple normal and neoplastic tissues including renal cell carcinoma and ovarian cancers. Renal cell carcinomas stained positive for PAX8 in 90% (110 of 122) of the cases and 100% of normal kidney stained PAX8 positive. In all cases of ovarian cancers 79% (181 of 229) expressed PAX8, and in thyroid cancer, PAX8 was expressed in 90% (9 of 10) cases. In endometrial cancers, 84% (113 of 134) of the cases were positive and in cervical cancer, 98% (1 of 60) squamous cell carcinomas cases were negative and 83% (5 of 6) cervical adenocarcinomas were positive. In bladder cancers, 93% of all the cases were negative including all bladder adenocarcinomas. PAX8 expression was observed in only one case of lung cancer (99% negative) and was 100% negative in cancers of the colon, breast, prostate, liver, testicular, stomach, esophagus, melanoma, gastrointestinal stromal tumors, leiomyosarcoma, and pheochromocytoma. The PAX8 specificity has been demonstrated in over 1100 cases of normal and neoplastic tissues. PAX8 is a specific and sensitive marker for renal cell and ovarian carcinomas and should be a valuable addition to the histopathology laboratory.
A Novel Mechanism of Cell Killing by Anti-topoisomerase II Bisdioxopiperazines*

Bisdioxopiperazines are a unique class of topoisomerase II inhibitors that lock topoisomerase II at a point in the enzyme reaction cycle where the enzyme forms a closed clamp around DNA. We examined cell killing by ICRF-187 and ICRF-193 in yeast cells expressing human topoisomerase II α (htop-IIα). Expression of htop-IIα in yeast cells sensitizes them to both ICRF-187 and ICRF-193, compared with cells expressing yeast topoisomerase II. ICRF-193 is still able to exert growth inhibition in the presence of genes encoding both ICRF-193-resistant and ICRF-193-sensitive htop-IIα enzymes, indicating that sensitivity to bisdioxopiperazines is dominant. Killing by ICRF-193 occurs more rapidly, than the killing in yeast cells due to a temperature-sensitive yeast topoisomerase II incubated at the non-permissive temperature. These results are reminiscent of a top-II poison such as etoposide. However, the killing caused by ICRF-193 and ICRF-187 is not enhanced by mutations in theRAD52 pathway. The levels of drug-induced DNA cleavage observed with htop-IIα in vitro is insufficient to explain the sensitivity induced by this enzyme in yeast cells. Finally, arrest of cells in G1 does not protect cells from ICRF-193 lethality, a result inconsistent with killing mechanisms due to catalytic inhibition of top-II or stabilization of a cleavable complex. We suggest that the observed pattern of cell killing is most consistent with a poisoning of htop-II by ICRF-193 by a novel mechanism. The accumulation of closed clamp conformations of htop-II induced by ICRF-193 that are trapped on DNA might interfere with transcription, or other DNA metabolic processes, resulting in cell death.
Conformational Stability and Catalytic Activity of HIV-1 Protease Are Both Enhanced at High Salt Concentration (*)

The activity of human immunodeficiency virus protease is markedly increased at elevated salt concentration. The structural basis of this effect has been explored by several independent methods by using both the wild-type enzyme and its triple mutant (Q7K/L33I/L63I) (Mildner, A. M., Rothrock, D. J., Leone, J. W., Bannow, C. A., Lull, J. M., Reardon, I. M., Sarcich, J. L., Howe, W. J., Tomich, C.-S. C., Smith, C. W., Heinrikson, R. L., and Tomasselli, A. G.(1994) Biochemistry 33, 9405-9413), designed to better resist autolysis. Monitoring the intrinsic fluorescence of the two enzymes during urea-mediated denaturation has shown that at high NaCl concentration, both the conformational stability (ΔG0) and the transition midpoint (D) between the folded and unfolded states increase, indicating that the salt stabilizes the enzyme structure. These equilibrium data are supported by kinetic studies on the urea-mediated unfolding by measuring fluorescence change, red shifting in the maximum of the emission spectrum, and far- and near-UV CD. The salt effects observed in urea-mediated unfolding reactions prevail upon heat denaturation. All these findings support the existence of a two-state equilibrium between the folded and unfolded proteins. The pH dependence of fluorescence intensity indicated that the conformation of human immunodeficiency virus type 1 protease should change in the catalytically competent pH region. It is concluded that preferential hydration stabilizes the protease structure in the presence of salt, providing entropic contribution to enhance the catalytic activity.
Relationships among sexual arousability, imagery ability, and introversion‐extraversion

Abstract On the assumption that cognitive processes mediate sexual learning and sexual behavior, it was hypothesized that there would be a positive correlation between self reports of sexual arousability and imagery ability. A positive relationship between imagery ability and introversion was also predicted. The Sexual Arousability Inventory, Betts Questionnaire Upon Mental Imagery (Shortened form), and the Eysenck Personality Inventory were administered to 100 male and 100 female undergraduate students. Males and females reporting greater ability to form clear, vivid images also reported significantly higher sexual arousability. Imagery ability was not related to introversion‐extraversion. Female extraverts reported higher sexual arousability than their introverted counterparts. Frequency of coitus and of coital orgasm were significantly related to reports of sexual arousability for males and females. Implications and limitations of the findings are discussed.
Clear Signals

Results from an earlier study indicated that senior planners in Oregon and Southwest Washington expect planning graduates to be equipped with strong communicative competencies built on a base of broad analytic skills. This article reports on an extension of that study to a survey of planners in California, Florida, Maryland, and New Jersey and confirms that these earlier findings are not unique to the Pacific Northwest. The challenge for planning educators is to design a core curriculum that responds to the skills and competencies demanded in practice and to adjust teaching practices and policies to recognize and reward the types of personal qualities sought by employers. Planning educators must consider carefully the field’s unique contributions and weave substance and values back into the curriculum.
‘Once More, With Irony’: Karaoke and Social Class

Abstract Karaoke’s mimetic character can provide a conduit for personal growth and interpersonal empathy. Yet karaoke is not always understood this way, and one factor determining how it is understood is social class. Karaoke’s class markers have been clear, though very different, in Eastern and Western cultures. Whereas in Japan karaoke first became popular among the upper‐middle class, in the US it was popularized by the working and lower‐middle classes. As karaoke gained a following among working‐class Americans it was often shunned by the urban middle class. Yet by the late 1990s an alternative aesthetic of karaoke, characterized by an ironic performance style, developed among middle‐class urbanites. This essay attempts to describe these opposing styles of mimetic and ironic performance, to explain the motives behind them, and to consider what happens when they come into contact.
Glucose-Coated Superparamagnetic Iron Oxide Nanoparticles Prepared by Metal Vapour Synthesis Are Electively Internalized in a Pancreatic Adenocarcinoma Cell Line Expressing GLUT1 Transporter

Iron oxide nanoparticles (IONP) can have a variety of biomedical applications due to their visualization properties through Magnetic Resonance Imaging (MRI) and heating with radio frequency or alternating magnetic fields. In the oncological field, coating IONP with organic compounds to provide specific features and to achieve the ability of binding specific molecular targets appears to be very promising. To take advantage of the high avidity of tumor cells for glucose, we report the development of very small glucose-coated IONP (glc-IONP) by employing an innovative technique, Metal Vapor Synthesis (MVS). Moreover, we tested the internalization of our gl-IONP on a tumor line, BxPC3, over-expressing GLUT 1 transporter. Both glc-IONP and polyvinylpyrrolidone-IONP (PVP-IONP), as control, were prepared with MVS and were tested on BxPC3 at various concentrations. To evaluate the role of GLUT-1 transporter, we also investigated the effect of adding a polyclonal anti-GLUT1 antibody. After proper treatment, the iron value was assessed by atomic absorption spectrometer, reported in mcg/L and expressed in mg of protein. Our IONP prepared with MVS were very small and homogeneously distributed in a narrow range (1.75-3.75 nm) with an average size of 2.7 nm and were super-paramagnetic. Glc-IONP were internalized by BxPC3 cells in a larger amount than PVP-IONP. After 6h of treatment with 50 mcg/mL of IONPs, the content of Fe was 1.5 times higher in glc-IONP-treated cells compared with PVP-IONP-treated cells. After 1h pre-treatment with anti-GLUT1, a reduction of 41% cellular accumulation of glc-IONP was observed. Conversely, the uptake of PVP-IONPs was reduced only by 14% with antibody pretreatment. In conclusion, MVS allowed us to prepare small, homogeneous, super-paramagnetic glc-IONP, which are electively internalized by a tumor line over-expressing GLUT1. Our glc-IONP appear to have many requisites for in vivo use.
Showstopper: The Partial CPU Load Tool

Provisioning strategies relying on CPU load may be suboptimal for many applications, because the relation between CPU load and application performance can be non-linear and complex. With the knowledge of the relation between CPU load and application performance, resource provisioning strategies could be tuned to a particular application, but the required knowledge is difficut to obtain, because classic benchmarking is not suited for performance evaluation of partial-load scenarios. As a remedy, we present Showstopper, a tool capable of achieving and sustaining a predefined partial CPU load (or replay a load trace) by controlling the execution of arbitrary CPU-bound workloads. By analyzing performance interference among applications running in colocated virtual machines, we demonstrate how Showstopper enables systematic and reproducible exploration of the platform- and application-specific relation between CPU load and application performance.
Category test and trail making test as measures of frontal lobe functions

Abstract A brief review of the literature reveals that many psychologists believe that certain tests measure frontal lobe deficits. However, recent carefully controlled studies suggest that neuropsychological deficits are far from specific for frontal versus nonfrontal lesions. In this study, we compared groups with frontal and nonfrontal cerebral lesions that were approximately equivalent for types of lesions and other variables. No intergroup differences were found on the Category Test and Part B of the Trail Making Test. The results suggest that neuropsychologists should adopt a more critical attitude concerning so-called “frontal lobe deficits. ”
Assessment of Coping With Invasive Procedures in Children With Cancer: State-Trait and Approach-Avoidant Dimensions

We examined the relation between children's trait-dependent coping styles and situation-specific coping behaviors during invasive medical procedures. Children with cancer (N = 66) completed the Children's Behavioral Style Scale (CBSS), a measure of approach-avoidant coping styles, and the Procedural Coping Questionnaire (PCQ), an analogous measure of coping behaviors specific to invasive procedures developed for this study. Parents also completed a parent-report version of the PCQ, and both parents and children rated the severity of the child's distress before, during, and after the procedure. Factor analysis of thePCQ produced 3 distinct factors with adequate internal reliability (attention to sensory stimuli, cognitive strategies, preference for sedation), none of which were directly interpretable within the CBSS approach-avoidant framework. CBSS scores did not significantly predict procedural distress, although the higher total coping behavior scores on the PCQ were associated with greater distress, su.
Photosynthetic Light Utilization Efficiency, Water Relations and Leaf Growth of C3 and CAM Tropical Orchids under Natural Conditions

Native orchid species of Singapore in their natural conditions experience stress from high irradiance, high temperatures and periods of extended low rainfall, which impact orchid plant physiology and lead to reduced growth and productivity. In this study, it was found that there was a reduction in photochemical efficiency of photosystem II (PSII) in 6 native orchid species under high light (HL) and Bulbophyllum membranaceum under low light (LL). There was chronic photoinhibition in these 6 orchid species over a period of 3 months after transplanting onto the tree trunks without watering and fertilization, especially in Coelogynes mayeriana and Bulbophyllum membranaceum under both HL and LL. This chronic photoinhibition caused by sustained period of water deficit in their natural conditions was later reversed by natural re-watering conditions from higher rainfall. These results indicate that water deficit has a greater impact on photosynthetic light utilization efficiency than excess light. The present study also showed that after natural rewatering, relative water content (RWC) of leaves and pseudobulbs generally increased. During the natural re-watering, total leaf area also gradually increased and reached maximum expansion after 7 weeks under both HL and LL, with some exceptions due to leaf abscission or decline in total leaf area, possibly a strategy for water conservation.
Convergence of Civil War and the Religious Right: Reimagining Somali Women

T he political crisis that led to the demise of the Somali Democratic Republic in 1991 has had vast, complex effects on Somali women’s lives. Somalia remains the only country in the world that has existed without a legitimate central government for the past sixteen years. This lack of government, together with continuing sectarian conflict, has resulted in the forced displacement of millions, affecting Somali women in numerous and drastic ways. The gendered consequences of war go beyond the physical and psychological violence to which women are subjected through rape and terror, extending to insidious practices and invented traditions that further consolidate patriarchy and exacerbate women’s social subordination. This article examines the ongoing production and reproduction of gender and sexuality in war-ravaged Somalia and areas to which Somali refugees have fled.
Volume and number of neurons of the human hippocampal formation in normal aging and Alzheimer's disease

In order to observe changes owing to aging and Alzheimer's disease (AD) in the volumes of subdivisions of the hippocampus and the number of neurons of the hippocampal formation, 18 normal brains from subjects who died of nonneurological causes and had no history of long‐term illness or dementia (ten of these brains comprised the aged control group) and 13 AD brains were analyzed. An optimized design for sampling, measuring volume by using the Cavalieri principle, and counting the number of neurons by using the optical disector was implemented on 50 μm‐thick cresyl‐violet sections.
Mutation of the MIF Type II Receptor in Two Brothers

The Müllerian inhibiting factor (MIF) is responsible for regression of Müllerian ducts during male sexual differentiation. Mutations in MIF or its type II receptor lead to persistence of the uterus and Fallopian tubes in male children--i.e., persistent Müllerian duct syndrome (PMDS). Both are rare autosomal recessive disorders. We report a 7-month-old male infant who underwent inguinal herniorrhaphy. Remnants of vas deferens and gonads with macroscopic characteristics of ovaries, along with Fallopian tubes and a rudimentary uterus, were found. Karyotype confirmed male sex. Molecular genetics revealed the most frequent MIF type II receptor gene mutation--27 bp deletion. Investigation of the older brother presenting bilateral cryptorchidism at 7 years of age led to similar clinical findings and the same mutation. We report here an MIF type II receptor mutation in two brothers, with the particularity that the surgical findings in the younger son initiated the diagnostic process in both children.