Miracle-dz/UniFAR-FTUs huggingface dataset:
The Lateralization of Motor Cortex Activation to Action-Words

What determines the laterality of activation in motor cortex for words whose meaning is related to bodily actions? It has been suggested that the neuronal representation of the meaning of action-words is shaped by individual experience. However, core language functions are left-lateralized in the majority of both right- and left-handers. It is still an open question to what degree connections between left-hemispheric core language areas and right-hemispheric motor areas can play a role in semantics. We investigated laterality of brain activation using fMRI in right- and left-handed participants in response to visually presented hand-related action-words, namely uni- and bi-manual actions (such as “throw” and “clap”). These stimulus groups were matched with respect to general (hand-) action-relatedness, but differed with respect to whether they are usually performed with the dominant hand or both hands. We may expect generally more left-hemispheric motor cortex activation for hand-related words in both handedness groups, with possibly more bilateral activation for left-handers compared to right-handers. In our study, both participant groups activated motor cortex bilaterally for bi-manual words. Interestingly, both groups also showed a left-lateralized activation pattern to uni-manual words. We argue that this reflects the effect of left-hemispheric language dominance on the formation of semantic brain circuits on the basis of Hebbian correlation learning.
Current issues in the economics of vaccination against dengue

ABSTRACT Dengue is a major public health concern in tropical and subtropical areas of the world. The prospects for dengue prevention have recently improved with the results of efficacy trials of a tetravalent dengue vaccine. Although partially effective, once licensed, its introduction can be a public health priority in heavily affected countries because of the perceived public health importance of dengue. This review explores the most immediate economic considerations of introducing a new dengue vaccine and evaluates the published economic analyses of dengue vaccination. Findings indicate that the current economic evidence base is of limited utility to support country-level decisions on dengue vaccine introduction. There are a handful of published cost-effectiveness studies and no country-specific costing studies to project the full resource requirements of dengue vaccine introduction. Country-level analytical expertise in economic analyses, another gap identified, needs to be strengthened to facilitate evidence-based decision-making on dengue vaccine introduction in endemic countries.
Presynaptic muscarinic acetylcholine receptors suppress GABAergic synaptic transmission in the intermediate grey layer of mouse superior colliculus

The intermediate grey layer (the stratum griseum intermediale; SGI) of the superior colliculus (SC) receives cholinergic inputs from the parabrachial region of the brainstem. It has been shown that cholinergic inputs activate nicotinic acetylcholine (nACh) receptors on projection neurons in the SGI. Therefore, it has been suggested that they facilitate the initiation of orienting behaviours. In this study, we investigated the effect of muscarinic acetylcholine (mACh) receptor activation on GABAergic synaptic transmission to SGI neurons using the whole‐cell patch‐clamp recording technique in slice preparations from mice. The GABAA receptor‐mediated inhibitory postsynaptic currents (IPSCs) evoked in SGI neurons by focal electrical stimulation were suppressed by bath application of 10 µm muscarine chloride. During muscarine application, both the paired‐pulse facilitation index and the coefficient of variation of IPSCs increased; however, the current responses induced by a transient pressure application of 1 mm GABA were not affected by muscarine. Muscarine reduced frequencies of miniature IPSCs (mIPSCs) while the amplitudes of mIPSCs remained unchanged. These results suggestd that mAChR‐mediated inhibition of IPSCs was of presynaptic origin. The suppressant effect of muscarine was antagonized by an M1 receptor antagonist, pirenzepine dihydrochloride (1 µm), and a relatively specific M3 receptor antagonist, 4‐DAMP methiodide (50 nm). By contrast, an M2 receptor antagonist, methoctramine tetrahydrochloride (10 µm), was ineffective. These results suggest that the cholinergic inputs suppress GABAergic synaptic transmission to the SGI neurons at the presynaptic site via activation of M1 and, possibly, M3 receptors. This may be an additional mechanism by which cholinergic inputs can facilitate tectofugal command generation.
C-terminal domain phosphatase-like family members (AtCPLs) differentially regulate Arabidopsis thaliana abiotic stress signaling, growth, and development

Cold, hyperosmolarity, and abscisic acid (ABA) signaling induce RD29A expression, which is an indicator of the plant stress adaptation response. Two nonallelic Arabidopsis thaliana (ecotype C24) T-DNA insertional mutations, cpl1 and cpl3, were identified based on hyperinduction of RD29A expression that was monitored by using the luciferase (LUC) reporter gene (RD29A:LUC) imaging system. Genetic linkage analysis and complementation data established that the recessive cpl1 and cpl3 mutations are caused by T-DNA insertions in AtCPL1 (Arabidopsis C-terminal domain phosphatase-like) and AtCPL3, respectively. Gel assays using recombinant AtCPL1 and AtCPL3 detected innate phosphatase activity like other members of the phylogenetically conserved family that dephosphorylate the C-terminal domain of RNA polymerase II (RNAP II). cpl1 mutation causes RD29A:LUC hyperexpression and transcript accumulation in response to cold, ABA, and NaCl treatments, whereas the cpl3 mutation mediates hyperresponsiveness only to ABA. Northern analysis confirmed that LUC transcript accumulation also occurs in response to these stimuli. cpl1 plants accumulate biomass more rapidly and exhibit delayed flowering relative to wild type whereas cpl3 plants grow more slowly and flower earlier than wild-type plants. Hence AtCPL1 and AtCPL3 are negative regulators of stress responsive gene transcription and modulators of growth and development. These results suggest that C-terminal domain phosphatase regulation of RNAP II phosphorylation status is a focal control point of complex processes like plant stress responses and development. AtCPL family members apparently have both unique and overlapping transcriptional regulatory functions that differentiate the signal output that determines the plant response.
Selecting students to a dormitory using AHP

A dormitory is an accommodation service of a university for the students especially who live far away from the educational institutions. In our country, with perfectly low price, a dormitory is needed for number of students. Each year student applicants are selected by a committee. It can be happened that a group of students may not be selected by a committee member without a reasonable reason. This fact can bring undesirable biases in educational area. Therefore, using rational and acceptable criteria for selecting students to stay in a dorm are needed. In this article, we propose to apply Analytical Hierarchy Process (AHP) as a Decision Support System (DSS) to select undergraduate students to a dormitory of a university. We provide 4 main criteria and 16 sub-criteria. Based on the method, an eigenvector is calculated and the Consistency Ratio (CR) can be determined from the eigenvector. By iteratively following the process of AHP, we then can have appropriate weight numbers that can be used for selecting proper students to the dormitories.
Long-term oral L-arginine administration improves peripheral and hepatic insulin sensitivity in type 2 diabetic patients.

UNLABELLED The aim of this study was to evaluate whether long-term administration of arginine acting through a normalization of NO/cyclic-guanosine-3' 5'-cyclic monophosphate (cGMP) pathway was able to ameliorate peripheral and hepatic insulin sensitivity in 12 lean type 2 diabetic patients. RESEARCH DESIGN AND METHODS A double-blind study was performed for 3 months. In the first month, patients were treated with their usual diet. Then they were randomly allocated into to groups. In group 1, patients were treated with diet plus placebo (orally three times per day) for 2 months. In group 2 patients were treated for 1 month with diet plus placebo orally, three times per day) and then for 1 month with diet plus L-arginine (3 g three times per day). At the end of the first and the second month of therapy, patients underwent a euglycemic-hyperinsulinemic clamp combined with [6,6-2H2] glucose infusion. A total of 10 normal subjects underwent the same test as control subjects. RESULTS In group 1, no changes in basal cGMP levels, systolic blood pressure, forearm blood flow, glucose disposal, and endogenous glucose production were observed throughout. In group 2, L-arginine normalized basal cGMP levels and significantly increased forearm blood flow by 36% and glucose disposal during the clamp by 34% whereas it decreased systolic blood pressure and endogenous glucose production by 14 and 29%, respectively. However, compared with normal subjects, L-arginine treatment was not able to completely overcome the defect in glucose disposal. CONCLUSIONS L-Arginine treatment significantly improves but does not completely normalizc peripheral and hepatic insulin sensitivity in type 2 diabetic patients.
Cross- and iso- oriented surrounds modulate the contrast response function: the effect of surround contrast.

The detectability and appearance of visual targets can be modulated by surround stimuli. In this study we asked how cross- and iso-oriented surrounds modulate contrast detection and discrimination in foveal vision. We systematically measured the Threshold-versus-Contrast (TvC) functions over a wide range of pedestal and surround contrasts. Our results show that cross-oriented surrounds lower the contrast threshold over the entire range of pedestal and surround contrasts, but iso-surround modulation of the TvC function is dependent on the relative contrast, being facilitative when the surround/pedestal contrast ratio Csur/Cped < 1 and suppressive when Csur/Cped > 1. Data fitting indicates that cross-surround modulation (facilitation) is mainly due to improved gain, except at very low and high surround contrasts. Iso-surround modulation on the other hand is more complicated, probably reflecting more than one surround process as determined by the relative contrast.
Structure Determination and Improved Model of Plant Photosystem I*

Photosystem I functions as a sunlight energy converter, catalyzing one of the initial steps in driving oxygenic photosynthesis in cyanobacteria, algae, and higher plants. Functionally, Photosystem I captures sunlight and transfers the excitation energy through an intricate and precisely organized antenna system, consisting of a pigment network, to the center of the molecule, where it is used in the transmembrane electron transfer reaction. Our current understanding of the sophisticated mechanisms underlying these processes has profited greatly from elucidation of the crystal structures of the Photosystem I complex. In this report, we describe the developments that ultimately led to enhanced structural information of plant Photosystem I. In addition, we report an improved crystallographic model at 3.3-Å resolution, which allows analysis of the structure in more detail. An improved electron density map yielded identification and tracing of subunit PsaK. The location of an additional ten β-carotenes as well as five chlorophylls and several loop regions, which were previously uninterpretable, are now modeled. This represents the most complete plant Photosystem I structure obtained thus far, revealing the locations of and interactions among 17 protein subunits and 193 non-covalently bound photochemical cofactors. Using the new crystal structure, we examine the network of contacts among the protein subunits from the structural perspective, which provide the basis for elucidating the functional organization of the complex.
Locomotor Recovery in Spinal Cord-Injured Rats Treated with an Antibody Neutralizing the Myelin-Associated Neurite Growth Inhibitor Nogo-A

The limited plastic and regenerative capabilities of axons in the adult mammalian CNS can be enhanced by the application of a monoclonal antibody (mAb), IN-1, raised against the myelin-associated neurite growth inhibitor Nogo-A. The aim of the present study was to investigate the effects of this treatment on the functional recovery of adult rats with a dorsal over-hemisection of the spinal cord. Directly after injury, half of the animals were implanted with mAb IN-1-secreting hybridoma cells, whereas the others received cells secreting a control antibody (anti-HRP). A broad spectrum of locomotor tests (open field locomotor) score, grid walk, misstep withdrawal response, narrow-beam crossing) was used to characterize locomotor recovery during the 5 weeks after the injury. In all behavioral tests, the recovery in the mAb IN-1-treated group was significantly augmented compared with the control antibody-treated rats. EMG recordings of flexor and extensor muscles during treadmill walking confirmed the improvement of the locomotor pattern in the mAb IN-1-treated rats; step-cycle duration, rhythmicity, and coupling of the hindlimbs were significantly improved. No differences between the two groups with regard to nociception were observed in the tail flick test 5 weeks after the operation. These results indicating improved functional recovery suggest that the increased plastic and regenerative capabilities of the CNS after Nogo-A neutralization result in a functionally meaningful rewiring of the motor systems.
Immunoregulatory cytokines in chronic hepatitis C virus infection: Pre‐ and posttreatment with interferon alfa

T lymphocytes and immunoregulatory cytokines may be important in the host response to hepatitis C virus (HCV) infection. T‐helper type 1 (Th1) cytokines (interleukin [IL]‐2, interferon gamma [IFN‐gamma]) are required for host antiviral immune responses, including cytotoxic T‐cell generation and natural killer cell activation, while T‐helper type 2 (Th2) cytokines (IL‐4,IL‐10) can inhibit the development of these effector mechanisms. In this study, the serum levels of Th1 and Th2 cytokines in patients (n = 23) infected with HCV were measured and compared with biochemical (alanine transaminase [ALT]) and viral (HCV RNA) indicators of infection. Serial cytokine levels were measured in a subset of 11 patients at 1 and 12 weeks during and at 1 week after interferon alfa (IFN‐α) therapy (n = 33 samples). Levels of circulating IL‐2, IL‐4, IL‐10, and IFN‐γ were significantly elevated in HCV patients versus normal controls (128 vs. 25 pg/mL, 3,045 vs. 29 pg/mL, 2,949 vs. 18 pg/mL, and 307 vs. 24 pg/mL respectively; P < .01). Treatment with IFN‐α decreased the levels of IL‐4 (321 ± 224 pg/mL), and IL‐10 (1,011 ± 344 pg/mL), which paralleled a decrease in HCV RNA (114 ± 27 vs. 25 ± 20 Eq/ml X 105, pre‐ vs. post‐IFN‐α [12 weeks];P <.05). These findings indicate that an activated T‐cell response, as manifest by increased circulating immunoregulatory cytokines, is present in patients with HCV liver disease. Furthermore, treatment with HCV liver disease. Furthermore, treatment with IFN‐α diminishes the Th2 cytokine response. Thus, modulation of T‐cell function and cytokine production may be one mechanism whereby IFN‐α therapy results in reduced viral burden.
A bestrophin‐like protein modulates the proton motive force across the thylakoid membrane in Arabidopsis

Abstract During photosynthesis, photosynthetic electron transport generates a proton motive force (pmf) across the thylakoid membrane, which is used for ATP biosynthesis via ATP synthase in the chloroplast. The pmf is composed of an electric potential (ΔΨ) and an osmotic component (ΔpH). Partitioning between these components in chloroplasts is strictly regulated in response to fluctuating environments. However, our knowledge of the molecular mechanisms that regulate pmf partitioning is limited. Here, we report a bestrophin‐like protein (AtBest), which is critical for pmf partitioning. While the ΔpH component was slightly reduced in atbest, the ΔΨ component was much greater in this mutant than in the wild type, resulting in less efficient activation of nonphotochemical quenching (NPQ) upon both illumination and a shift from low light to high light. Although no visible phenotype was observed in the atbest mutant in the greenhouse, this mutant exhibited stronger photoinhibition than the wild type when grown in the field. AtBest belongs to the bestrophin family proteins, which are believed to function as chloride (Cl−) channels. Thus, our findings reveal an important Cl− channel required for ion transport and homeostasis across the thylakoid membrane in higher plants. These processes are essential for fine‐tuning photosynthesis under fluctuating environmental conditions.
Secrecy coding for the wiretap channel using best known linear codes

A special case of wiretap channel is studied and analysed when the main channel is an error free channel and the eavesdropper channel is a binary symmetric channel. The goal of this work is to maximise the equivocation on the eavesdropper side by using a combination of the technique of the McEliece cryptosystem using Best Known Linear Codes(BKLC) coupled with syndrome coding. It is shown that as a result the communication security is improved. In this paper, two Best known linear codes are analysed which increase the equivocation on the eavesdropper side. Two encoding stages are employed. The first stage employs a syndrome coding scheme based on the (23,12,7) binary Golay code and the second stage employs the McEliece cryptosystem technique using BKLC. Analysis shows that the arrangement reduces the information leakage to the eavesdropper compared to previously published schemes.
SHRD: Improving Spatial Locality in Flash Storage Accesses by Sequentializing in Host and Randomizing in Device

Recent advances in flash memory technology have reduced the cost-per-bit of flash storage devices such as solid-state drives (SSDs), thereby enabling the development of large-capacity SSDs for enterprise-scale storage. However, two major concerns arise in designing SSDs. The first concern is the poor performance of random writes in an SSD. Server workloads such as databases generate many random writes; therefore, this problem must be resolved to enable the usage of SSDs in enterprise systems. The second concern is that the size of the internal DRAM of an SSD is proportional to the capacity of the SSD. The peculiarities of flash memory require an address translation layer called flash translation layer (FTL) to be implemented within an SSD. The FTL must maintain the address mapping table in the internal DRAM. Although the previously proposed demand map loading technique can reduce the required DRAM size, the technique aggravates the poor random performance. We propose a novel address reshaping technique called sequentializing in host and randomizing in device (SHRD), which transforms random write requests into sequential write requests in the block device driver by assigning the address space of the reserved log area in the SSD. Unlike previous approaches, SHRD can restore the sequentially written data to the original location without requiring explicit copy operations by utilizing the address mapping scheme of the FTL. We implement SHRD in a real SSD device and demonstrate the improved performance resulting from SHRD for various workloads.
Structure, mechanical properties, and stress corrosion behaviour of high strength spray deposited 7000 series aluminium alloy

AbstractA 7000 series high strength aluminium alloy was produced by spray deposition via the Osprey process. This alloy, designated AlZn11MgCu, exhibits an excellent combination of fracture toughness and strength in both the peak aged T6 and overaged T7 conditions. The yield strength and fracture toughness at room temperature are 700 MN m−2 and about 40 MN m−3/2 in the T6 temper, and 500 MN m−2 and 75 MN m−3/2 in the T7 temper, respectively. The exceptional high fracture toughness is attributed to the absence of coarse constituents and oxides. The microstructure is homogeneous, free of segregation, and has a fine grain size. The hardening precipitates in the T6 temper are mainly η′, and in the T7 temper they are η (MgZn2), resulting in a different fracture behaviour; in the T6 temper the fracture mode is microshearing and in the T7 temper the fracture mode is ductile failure. Both T6 and T7 conditions show a stress corrosion crack growth rate higher than that of comparable alloys, 7075-T651 and 7075-T7351.
A novel differential diagnostic model for multiple primary lung cancer: Differentially-expressed gene analysis of multiple primary lung cancer and intrapulmonary metastasis

The incidence of synchronous multiple primary lung cancer (MPLC) is increasing. However, present diagnostic methods are unable to satisfy the individualized treatment requirements of patients with MPLC. The present study aimed to establish a quantitative mathematical model and analyze its diagnostic value for distinguishing between MPLC and cases of the histologically similar disease, intrapulmonary metastasis (IPM). The sum value of the differential expression ratios of four proteins, namely p53, p16, p27 and c-erbB2, was evaluated by immunohistochemically-staining specimens of primary cancers, second separate cancers, metastatic lymph nodes and metastatic cancers. The sum value of the differential expression ratio of the four proteins from the primary tumor and the lymph-node metastasis or metastatic cancer was <90 in the 11 patients with a single metastatic cancer and in the 30 patients with lymph-node metastasis, but was >90 in the 14 patients with different histological types of MPLC. Therefore, a quantitative differentially-expressed gene mathematical model was established as follows: Sum of the differential expression ratios = p16T1 − T + p27T1 − T2 + C-erbB2T1 − T2 + p53T1 − T2, where T1 is the primary cancer and T2 is the lymph node metastasis, metastatic cancer or the second separate cancer. The quantitative differentially-expressed gene mathematical model is considered to be a useful tool for distinguishing between MPLC and IPM.
Sensitivity of northern redbelly dace, Phoxinus eos, to chemical alarm cues

The northern redbelly dace, Phoxinus eos (Cope, 1862), is subject to predation by brook trout, Salvelinus fontinalis (Mitchill, 1814), in Canadian Shield lakes, particularly when individuals migrate to the pelagic zone at sunset to feed on zooplankton and fish shoals break up into single individuals. The objectives of the present study were to (i) determine whether northern redbelly dace react to skin extracts from conspecifics and thus potentially use chemical alarms to detect predators in nature, (ii) characterize the fright reaction in northern redbelly dace under different concentrations of alarm substance, and (iii) estimate the active space of the alarm substance in this species. Northern redbelly dace responded to skin extracts of conspecifics with a series of antipredator behaviours. The dace moved closer to the substrate and away from the area where the alarm substance was injected, increased both the cohesion and polarization of their schools, and performed more dashing and freezing behaviours.
Outcomes in patients with systemic lupus erythematosus with and without a prolonged serologically active clinically quiescent period

Serologically active clinically quiescent (SACQ) systemic lupus erythematosus (SLE) patients' discordance presents a clinical dilemma. Does active serology alone warrant treatment? We explore outcomes in patients with and without a prolonged SACQ period, comparing the rate of damage accrual by Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI) and incidences of renal damage and coronary artery disease (CAD) over a decade.