Miracle-dz/UniFAR-FTUs huggingface dataset:
Fast Sequence Component Analysis for Attack Detection in Synchrophasor Networks

Modern power systems have begun integrating synchrophasor technologies into part of daily operations. Given the amount of solutions offered and the maturity rate of application development it is not a matter of "if" but a matter of "when" in regards to these technologies becoming ubiquitous in control centers around the world. While the benefits are numerous, the functionality of operator-level applications can easily be nullified by injection of deceptive data signals disguised as genuine measurements. Such deceptive action is a common precursor to nefarious, often malicious activity. A correlation coefficient characterization and machine learning methodology are proposed to detect and identify injection of spoofed data signals. The proposed method utilizes statistical relationships intrinsic to power system parameters, which are quantified and presented. Several spoofing schemes have been developed to qualitatively and quantitatively demonstrate detection capabilities.
5-Ethynyluracil (776C85): modulation of 5-fluorouracil efficacy and therapeutic index in rats bearing advanced colorectal carcinoma.

5-Ethynyluracil (EU; 776C85) is a potent inactivator of dihydropyrimidine dehydrogenase, the enzyme that rapidly degrades 5-fluorouracil (FUra). We have investigated the antitumor activity and toxicity of FUra alone and in combination with EU in rats bearing advanced colon carcinoma. Two schedules were studied: (a) FUra daily for 4 days i.v. push (daily x 4); and (b) FUra administered i.v. push weekly for 3 weeks (weekly x 3). EU was administered at 1 mg/kg 1 h before FUra and for two additional days post-FUra therapy. The maximum tolerated doses of FUra alone were 35 and 100 mg/kg/day and for FUra plus EU were 10 and 15 mg/kg/day for the daily x 4 and weekly x 3 schedules, respectively. The dose-limiting toxicities were diarrhea and stomatitis both for FUra alone and for FUra in combination with EU. Although EU was not toxic and not active as an antitumor agent, it markedly improved the efficacy and therapeutic index of FUra. The antitumor activity of FUra was schedule dependent, yielding 13% complete and sustained tumor regression on the weekly schedule and no complete and sustained tumor regression on the daily schedule. The combination of FUra and EU produced 100% complete and sustained tumor regression on both schedules. The therapeutic index was < or = 1 for FUra alone and 6 for FUra with EU. EU was considerably more effective than either leucovorin or N-(phosphonacetyl)-L-aspartate as a modulator of FUra. Leucovorin or N-(phosphonacetyl)-L-aspartate induced minimum improvements on the daily schedule and only increased the therapeutic index to 1.5 on the weekly schedule. Because a 4-day continuous infusion of FUra alone at the maximum tolerated dose did not improve FUra therapy, we conclude that the improvements by EU involve additional modulations that complement the enhanced exposure of FUra.
Constructing participation practice: an ANT account

Purpose – The purpose of this paper is to explore how participation can be investigated as an open and non‐exclusive sociomaterial practice.Design/methodology/approach – Framed by translation discourse and a view of the social world as a sociology of associations, participation in organisations is conceptualised as a network building practice. Actor‐network theory (ANT) is used as an analytical method to describe the character of everyday constructions of participation practice related to changes in curriculum and its delivery in an Australian independent school.Findings – It was found that participation was performed as an uncertain practice. People in relation with technology and other material entities, co‐constructed and re‐constructed multiple participation practices.Practical implications – For researchers, an ANT account of constructing participation practices provides an additional analytical tool for investigating participation in terms of relationality. The idea of constructing participation as .
Impact of the Consumption of Tea Polyphenols on Early Atherosclerotic Lesion Formation and Intestinal Bifidobacteria in High-Fat-Fed ApoE−/− Mice

There is an increasing interest in the effect of dietary polyphenols on the intestinal microbiota and the possible associations between this effect and the development of some cardiovascular diseases, such as atherosclerosis (AS). However, limited information is available on how these polyphenols affect the gut microbiota and AS development. This study was designed to evaluate the modulation of dietary tea polyphenols (TPs) on intestinal Bifidobacteria (IB) and its correlation with AS development in apolipoprotein E-deficient (ApoE−/−) mice. Fifty C57BL/6 ApoE−/− mice were randomized into one of the five treatment groups (n = 10/group): control group fed normal diet (CK); a group fed a high-fat diet (HFD); and the other three groups fed the same HFD supplemented with TPs in drinking water for 16 weeks. The total cholesterol and low-density lipoprotein cholesterol (LDL-C) were decreased significantly (P < 0.05) after TP interference. In addition, the TP diet also decreased the plaque area/lumen area (PA/LA) ratios (P < 0.01) in the TP diet group. Interestingly, copies of IB in the gut of ApoE−/− mice were notably increased with TP interference. This increase was dose dependent (P < 0.01) and negatively correlated with the PA/LA ratio (P < 0.05). We conclude that TPs could promote the proliferation of the IB, which is partially responsible for the reduction of AS plaque induced by HFD.
La experiencia de la paternidad y la maternidad: análisis del discurso de las creencias sobre la crianza y el cuidado infantil

Resumen En el artículo se estudian las diferencias de género en las tareas de cuidado infantil, analizando si se sustentan en el esquematismo de género. En la investigación se ha usado una metodología cualitativa, basada en nueve grupos de discusión realizados en el Principado de Asturias. Los hallazgos más importantes indican que los varones participan en las tareas de cuidado infantil, pero la mayor implicación corresponde a la mujer. Asimismo, se concluye que padres y madres mantienen viejos modelos de relación parental que demuestran la persistencia de las estructuras sociales de género. El artículo concluye sugiriendo la implementación de programas de educación familiar que modifiquen las creencias acerca del papel que juegan padres y madres en la educación de sus hijos e hijas.
Anonymizing large transaction data using MapReduce

Publishing transaction data is important to applications such as marketing research and biomedical studies. Privacy is a concern when publishing such data since they often contain person-specific sensitive information. To address this problem, different data anonymization methods have been proposed. These methods have focused on protecting the associated individuals from different types of privacy leaks as well as preserving utility of the original data. But all these methods are sequential and are designed to process data on a single machine, hence not scalable to large datasets. Recently, MapReduce has emerged as a highly scalable platform for data-intensive applications. In this work, we consider how MapReduce may be used to provide scalability in large transaction data anonymization. More specifically, we consider how setbased generalization methods such as RBAT (Rule-Based Anonymization of Transaction data) may be parallelized using MapReduce. Set-based generalization methods have some desirable features for transaction anonymization, but their highly iterative nature makes parallelization challenging. RBAT is a good representative of such methods. We propose a method for transaction data partitioning and representation. We also present two MapReduce-based parallelizations of RBAT. Our methods ensure scalability when the number of transaction records and domain of items are large. Our preliminary results show that a direct parallelization of RBAT by partitioning data alone can result in significant overhead, which can offset the gains from parallel processing. We propose MR-RBAT that generalizes our direct parallel method and allows to control parallelization overhead. Our experimental results show that MR-RBAT can scale linearly to large datasets and to the available resources while retaining good data utility.
The Fat Mass and Obesity Associated Gene FTO Functions in the Brain to Regulate Postnatal Growth in Mice

FTO (fat mass and obesity associated) was identified as an obesity-susceptibility gene by several independent large-scale genome association studies. A cluster of SNPs (single nucleotide polymorphism) located in the first intron of FTO was found to be significantly associated with obesity-related traits, such as body mass index, hip circumference, and body weight. FTO encodes a protein with a novel C-terminal α-helical domain and an N-terminal double-strand β-helix domain which is conserved in Fe(II) and 2-oxoglutarate-dependent oxygenase family. In vitro, FTO protein can demethylate single-stranded DNA or RNA with a preference for 3-methylthymine or 3-methyluracil. Its physiological substrates and function, however, remain to be defined. Here we report the generation and analysis of mice carrying a conditional deletion allele of Fto. Our results demonstrate that Fto plays an essential role in postnatal growth. The mice lacking Fto completely display immediate postnatal growth retardation with shorter body length, lower body weight, and lower bone mineral density than control mice, but their body compositions are relatively normal. Consistent with the growth retardation, the Fto mutant mice have reduced serum levels of IGF-1. Moreover, despite the ubiquitous expression of Fto, its specific deletion in the nervous system results in similar phenotypes as the whole body deletion, indicating that Fto functions in the central nerve system to regulate postnatal growth.
Cultural Complexity: Studies in the Social Organization of Meaning

A rich, witty, and accessible introduction to the anthropology of contemporary cultures,Cultural Complexity emphasizes that culture is organized in terms of states, markets, and movements. Hannerz pays special attention to the interplay between the centralizing agencies of culture, such as schools and media, and the decentering diversity of subcultures, and considers the special role of cities as the centers of cultural growth. Hannerz discusses cultural process in small-scale societies, the concept of subcultures, and the economics and politics of culture. Finally, he presents the twentieth-century globalization of culture as a process of cultural diffusion, polycentralism, and local innovation, focusing on periods of intensive cultural productivity in Vienna, Calcutta, and San Francisco.
Otologic manifestations of Wolf-Hirschhorn syndrome.

OBJECTIVE To determine if haploinsufficiency for chromosome 4p16.3 in Wolf-Hirschhorn syndrome (WHS) is associated with cochlear hearing loss. DESIGN Case series. SETTING Tertiary care center. PATIENTS Six patients with WHS were identified through a database and charts were retrospectively reviewed. MAIN OUTCOME MEASURES Presence of sensorineural hearing loss as assessed by brainstem auditory evoked response. RESULTS One of the 6 patients had sensorineural hearing loss. Three of the 6 patients had chronic otitis media with effusion and underwent bilateral tympanostomy tube placement; 2 of these 3 had cleft lip and palate, and 1 had a bifid uvula. One of the 6 patients had spontaneous nystagmus. Five of the 6 patients had preauricular and/or auricular abnormalities. CONCLUSIONS More than 25 genes for nonsyndromic hereditary hearing impairment have been mapped. One of these genes, DFNA6, was identified through linkage analysis of a family with dominant, progressive, low-frequency sensorineural hearing loss. DFNA6 maps to chromosome 4p16.3, a region that is partially deleted in patients with WHS. In our series, we identified the second patient with WHS in the literature with bilateral sensorineural hearing loss. The incidence and type of otologic findings are consistent with those reported in the literature. Analysis of patients with chromosomal rearrangements represents one strategy toward identifying candidate genes for genetic hearing impairment.
Monitoring embolism in real time.

We have known since the 17th century that emboli can cause stroke but, despite their occasional visualisation in the retinal circulation, a diagnosis of embolic stroke is usually one of “guilt by association,” which is made by the detection of an appropriate embolic source in a patient with stroke. Frequently, >1 potential embolic source exists; determining which is clinically relevant may be impossible. The indirect diagnosis of embolic stroke also results in management difficulties in stroke prevention. For example, in atrial fibrillation, treatment failure can only be determined by the onset of stroke or systemic embolization. Recently, studies have evaluated a technique that allows the direct visualisation of circulating emboli. This offers exciting potential applications in both the diagnosis and management of patients at risk of cerebral and systemic embolism. Since the 1960s, we have known that gaseous emboli can be detected in blood using Doppler ultrasound. The large acoustic impedance difference between air and blood results in a scattering of ultrasound at the blood-air interface and a marked increase in received ultrasound intensity as the bubble passes. This results in a brief, high-intensity signal. This technique was applied to develop safe decompression limits in divers and to investigate air embolism during cardiopulmonary bypass. In 1990, while recording for air emboli during carotid endarterectomy, similar signals, but of lower intensity, were noted during manipulation of the carotid bifurcation.1 This was before arterial opening and, therefore, these signals could not represent air emboli; it was suggested that they represented thrombus and platelet emboli. Despite initial scepticism that these signals represented anything other than artifacts or flow turbulence, it has been clearly demonstrated experimentally that thrombus, platelet, and atheroma emboli result in these characteristic Doppler signals.2 The technique is highly sensitive and specific, and similar signals cannot be produced by …
Is radiotherapy curative for stage I and II low-grade follicular lymphoma? Results of a long-term follow-up study of patients treated at Stanford University.

PURPOSE To evaluate retrospectively the results of radiotherapy for 177 patients with stage I (n = 73 [41%]) and II (n = 104 [59%]) follicular small cleaved-cell and follicular mixed small cleaved-cell and large-cell non-Hodgkin's lymphoma (NHL) treated in the Department of Radiation Oncology, Stanford University between 1961 and 1994. PATIENTS AND METHODS Histology was follicular small cleaved-cell in 101 (57%) cases and follicular mixed small cleaved-cell and large-cell in 76 (43%). Forty-five patients (25%) had staging laparotomy; 34 (19%) had extranodal involvement. All patients had received radiotherapy, either to one side of the diaphragm (involved or extended field) or to both sides (total lymphoid irradiation [TLI] or subtotal lymphoid irradiation [STLI]. Radiotherapy doses ranged from 35 to 50 Gy. RESULTS The median follow-up duration was 7.7 years. The longest follow-up duration was 31 years. Actuarial survival rates at 5, 10, 15, and 20 years were 82%, 64%, 44%, and 35%, respectively. The median survival time was 13.8 years. At 5, 10, 15, and 20 years, 55%, 44%, 40%, and 37% of patients, respectively, were relapse-free. Only five of 47 patients who reached 10 years without relapse subsequently developed recurrence. Survival and freedom from relapse (FFR) were significantly worse for older patients. Relapse rates were lower following treatment on both sides of the diaphragm or staging laparotomy. Univariate analysis showed that youth and staging laparotomy were associated with significantly better survival and that FFR was better following treatment on both sides of the diaphragm or laparotomy. CONCLUSION Radiotherapy remains the treatment of choice for early-stage low-grade follicular lymphomas. Patients who have remained free of disease for 10 years are unlikely to relapse.
Explanation and Verbalization in a Computer-Assisted Search Task

Three experiments examine the effects of two different forms of explanation on assisted performance on a complex search task. The task involves determining which of a set of factories is responsible for polluting a river by testing the river for the presence or absence of various pollutants. All subjects receive computer suggestions as to which pollutants they should test for. In addition, some subjects receive an explanation of the principle according to which the advice program works. Two forms of explanation are compared. Experiment 1 shows that subjects who are allowed to ask “why” each computer recommendation is made perform significantly better than those who are provided with a block text of explanation at the start of each trial. Experiment 2 shows that the latter type of explanation is not completely ineffective, however. Subjects who are required to verbalize following the single explanation perform significantly better than do subjects who are required to verbalize but who have not received any form of explanation. Finally, Experiment 3 shows that subjects who receive the multiple “why” explanations or the explanation/verbalization combination maintain a superior performance level on subsequent unaided trials.
A Feasibility Study of Bilateral Anodal Stimulation of the Prefrontal Cortex Using High-Definition Electrodes in Healthy Participants

Transcranial direct current stimulation (tDCS) studies often use one anode to increase cortical excitability in one hemisphere. However, mental processes may involve cortical regions in both hemispheres. This study’s aim was to assess the safety and possible effects on affect and working memory of tDCS using two anodes for bifrontal stimulation. A group of healthy subjects participated in two bifrontal tDCS sessions on two different days, one for real and the other for sham stimulation. They performed a working memory task and reported their affect immediately before and after each tDCS session. Relative to sham, real bifrontal stimulation did not induce significant adverse effects, reduced decrement in vigor-activity during the study session, and did not improve working memory. These preliminary findings suggest that bifrontal anodal stimulation is feasible and safe and may reduce task-related fatigue in healthy participants. Its effects on neuropsychiatric patients deserve further study.
Term proximity scoring for ad-hoc retrieval on very large text collections

We propose an integration of term proximity scoring into Okapi BM25. The relative retrieval effectiveness of our retrieval method, compared to pure BM25, varies from collection to collection.We present an experimental evaluation of our method and show that the gains achieved over BM25 as the size of the underlying text collection increases. We also show that for stemmed queries the impact of term proximity scoring is larger than for unstemmed queries.
Patterns of Corrective Feedback and Uptake in an Adult ESL Classroom

This article begins by synthesizing findings from observational classroom research on corrective feedback and then presents an observational study of patterns of error treatment in an adult ESL classroom. The study examines the range and types of feedback used by the teacher and their relationship to learner uptake and immediate repair of error. The database consists of 10 hours of transcribed interaction, comprising 1,716 student turns and 1,641 teacher turns, coded in accordance with the categories identified in Lyster and Ranta's (1997) model of corrective discourse. The results reveal a clear preference for implicit types of reformulative feedback, namely, recasts and translation, leaving little opportunity for other feedback types that encourage learner-generated repair. Consequently, rates of learner uptake and immediate repair of error are low in this classroom. These results are discussed in relation to the hypothesis that L2 learners may benefit more from retrieval and production processes than from only hearing target forms in the input.
Plasma N-terminal pro-brain natriuretic peptide and the ECG in the assessment of left-ventricular systolic dysfunction in a high risk population.

AIMS To examine the value of N-terminal pro-brain natriuretic peptide, abnormal electrocardiogram and other baseline clinical and laboratory variables in identifying patients with left ventricular systolic dysfunction in a high risk population. METHODS AND RESULTS We studied 243 patients (129 male, median age 73 years, range 20-94) referred for echocardiography. The relationship between left ventricular wall motion index and log N-terminal pro-brain natriuretic peptide, log creatinine, electrocardiogram, age, history of hypertension, history of ischaemic heart disease, gender, valvular disease and current drug therapy was examined using regression analysis. There was a strong correlation between N-terminal pro-brain natriuretic peptide and left ventricular wall motion index for the whole population (r=-0.624, P<0.001) and in those receiving diuretic +/- angiotensin converting enzyme inhibitor (r= -0.661, P<0.005) and in those receiving neither (r=-0.584, P<0. 005). On multiple regression analysis, log N-terminal pro-brain natriuretic peptide (P<0.001), age (P=0.015), current diuretic (P=0. 002) or angiotensin converting enzyme inhibitor use (P=0.001) and male gender (P=0.026) were independently associated with a low left ventricular wall motion index. Log N-terminal pro-brain natriuretic peptide alone (R(2)=39%) was a better predictor of left ventricular wall motion index than any other single or combination of factors. Plasma N-terminal pro-brain natriuretic peptide>275 pmol l(-1)predicted left ventricular wall motion index < or =1.2 with a sensitivity of 93.8%, a specificity of 55% and a negative predictive value of 93%. Left ventricular function was impaired in 18/36 patients with a normal electrocardiogram, in all of whom N-terminal pro-brain natriuretic peptide was >275 fmol ml(-1). CONCLUSION Of the variables studies, N-terminal pro-brain natriuretic peptide had the strongest correlation with reduced left ventricular wall motion index. The electrocardiogram had a poor predictive value for left ventricular systolic dysfunction in this population. Plasma N-terminal pro-brain natriuretic peptide can usefully predict patients with a reduced left ventricular wall motion index in whom echocardiographic examination may be appropriate.