Miracle-dz/UniFAR-FTUs huggingface dataset:
Age-Related Differences in Neural Activity during Memory Encoding and Retrieval: A Positron Emission Tomography Study

Positron emission tomography (PET) was used to compare regional cerebral blood flow (rCBF) in young (mean 26 years) and old (mean 70 years) subjects while they were encoding, recognizing, and recalling word pairs. A multivariate partial-least-squares (PLS) analysis of the data was used to identify age-related neural changes associated with (1) encoding versus retrieval and (2) recognition versus recall. Young subjects showed higher activation than old subjects (1) in left prefrontal and occipito-temporal regions during encoding and (2) in right prefrontal and parietal regions during retrieval. Old subjects showed relatively higher activation than young subjects in several regions, including insular regions during encoding, cuneus/precuneus regions during recognition, and left prefrontal regions during recall. Frontal activity in young subjects was left-lateralized during encoding and right-lateralized during recall [hemispheric encoding/retrieval asymmetry (HERA)], whereas old adults showed little frontal activity during encoding and a more bilateral pattern of frontal activation during retrieval. In young subjects, activation in recall was higher than that in recognition in cerebellar and cingulate regions, whereas recognition showed higher activity in right temporal and parietal regions. In old subjects, the differences in blood flow between recall and recognition were smaller in these regions, yet more pronounced in other regions. Taken together, the results indicate that advanced age is associated with neural changes in the brain systems underlying encoding, recognition, and recall. These changes take two forms: (1) age-related decreases in local regional activity, which may signal less efficient processing by the old, and (2) age-related increases in activity, which may signal functional compensation.
TLR 2 and CD14 Mediate Innate Immunity and Lung Inflammation to Staphylococcal Panton–Valentine Leukocidin In Vivo

The pore-forming toxin Panton–Valentine leukocidin (PVL) is carried by community-acquired methicillin-resistant Staphylococcus aureus and associated with necrotizing pneumonia together with poor prognosis of infected patients. Although the cell-death–inducing properties of PVL have previously been examined, the pulmonary immune response to PVL is largely unknown. Using an unbiased transcriptional profiling approach, we show that PVL induces only 29 genes in mouse alveolar macrophages, which are associated with TLR signaling. Further studies indicate that PVL directly binds to TLR2 and induces immune responses via NF-κB in a TLR2, CD14, MyD88, IL-1R–associated kinase 1, and TNFR-associated factor 6-dependent manner. PVL-mediated inflammation is independent of pore formation but strongly depends on the LukS subunit and is suppressed in CD14/TLR2−/− cells. In vivo PVL or LukS induced a robust inflammatory response in lungs, which was diminished in CD14/TLR2−/− mice. These results highlight the proinflammatory properties of PVL and identify CD14/TLR2 as an essential receptor complex for PVL-induced lung inflammation.
Non-metric affinity propagation for unsupervised image categorization

Unsupervised categorization of images or image parts is often needed for image and video summarization or as a preprocessing step in supervised methods for classification, tracking and segmentation. While many metric-based techniques have been applied to this problem in the vision community, often, the most natural measures of similarity (e.g., number of matching SIFT features) between pairs of images or image parts is non-metric. Unsupervised categorization by identifying a subset of representative exemplars can be efficiently performed with the recently-proposed 'affinity propagation' algorithm. In contrast to k-centers clustering, which iteratively refines an initial randomly-chosen set of exemplars, affinity propagation simultaneously considers all data points as potential exemplars and iteratively exchanges messages between data points until a good solution emerges. When applied to the Olivetti face data set using a translation-invariant non-metric similarity, affinity propagation achieves a much lower reconstruction error and nearly halves the classification error rate, compared to state-of-the-art techniques. For the more challenging problem of unsupervised categorization of images from the CaltechlOl data set, we derived non-metric similarities between pairs of images by matching SIFT features. Affinity propagation successfully identifies meaningful categories, which provide a natural summarization of the training images and can be used to classify new input images.
Expression of BDNF and NT‐3 during the ontogeny and regeneration of the lacertidian (Gallotia galloti) visual system

Retinal ganglion cell (RGC) axons regrow spontaneously after optic nerve (ON) transection in G. galloti. Because brain‐derived neurotrophic factor (BDNF) is considered the major neurotrophin participating in vertebrate visual system development and promotes RGC survival, we investigated its distribution using dual‐labeling immunohistochemistry for neuronal and glial markers. We examined the developing and regenerating lizard visual system at 1, 3, 6, 9, and 12 months postlesion to comparatively evaluate BDNF expression patterns. BDNF was detected from midembryonic stages (E35) in both retinal plexiform layers, and in radial glial processes in the tectum. Moreover, RGC axon staining was detected at late prenatal stages (E39), showing a transient punctate staining which progressed in a temporo‐spatial pattern that was similar to myelination. Strong expression in RGC axons was maintained in adults. However, transient downregulation of BDNF staining occurred on the experimental side one month after ON transection followed by a gradual recovery with extensive punctate/swelling distribution and persistent upregulation at 12 months. Conversely, quantitative PCR analysis for 1 and 12 months regenerate lizards showed downregulation of the ratio of BDNF mRNA expression at 12 months and nonsignificant changes of NT‐3 transcripts. In summary, we demonstrate that BDNF and NT‐3 are abundantly expressed during lizard visual system ontogeny and regeneration suggesting their participation inthe development, maintenance and plasticity of the system. © 2011Wiley Periodicals, Inc.Develop Neurobiol 71: 836–853, 2011
Individual Differences in Impulsivity Predict Head Motion during Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) provides valuable data for understanding the human mind and brain disorders, but in-scanner head motion introduces systematic and spurious biases. For example, differences in MRI measures (e.g., network strength, white matter integrity) between patient and control groups may be due to the differences in their head motion. To determine whether head motion is an important variable in itself, or just simply a confounding variable, we explored individual differences in psychological traits that may predispose some people to move more than others during an MRI scan. In the first two studies, we demonstrated in both children (N = 245) and adults (N = 581) that head motion, estimated from resting-state functional MRI and diffusion tensor imaging, was reliably correlated with impulsivity scores. Further, the difference in head motion between children with attention deficit hyperactivity disorder (ADHD) and typically developing children was largely due to differences in impulsivity. Finally, in the third study, we confirmed the observation that the regression approach, which aims to deal with motion issues by regressing out motion in the group analysis, would underestimate the effect of interest. Taken together, the present findings provide empirical evidence that links in-scanner head motion to psychological traits.
Active Learning for Level Set Estimation

Many information gathering problems require determining the set of points, for which an unknown function takes value above or below some given threshold level. We formalize this task as a classification problem with sequential measurements, where the unknown function is modeled as a sample from a Gaussian process (GP). We propose LSE, an algorithm that guides both sampling and classification based on GP-derived confidence bounds, and provide theoretical guarantees about its sample complexity. Furthermore, we extend LSE and its theory to two more natural settings: (1) where the threshold level is implicitly defined as a percentage of the (unknown) maximum of the target function and (2) where samples are selected in batches. We evaluate the effectiveness of our proposed methods on two problems of practical interest, namely autonomous monitoring of algal populations in a lake environment and geolocating network latency.
Statistical guidelines for studies of the theory of reasoned action and the theory of planned behaviour

Abstract We identify potential problems in the statistical analysis of social cognition model data, with special emphasis on the theories of reasoned action (TRA) and planned behaviour (TPB). Some statistical guidelines are presented for empirical studies of the TRA and the TPB based upon multiple linear regression and structural equation modelling (SEM). If the model is tested using multiple regression, the assumptions of this technique must be considered and variables transformed if necessary. Adjusted R2 (not R2) should be used as a measure of explained variance and semipartial correlations are useful in assessing each component's unique contribution to explained variance. R2 is not an indicator of model adequacy and residuals should be examined. Expectancy-value variables that are the product of expectancy and value measures represent the interaction term in a multiple regression and should not be used. SEM approaches make explicit the assumptions of unidimensionality of constructs in the TRA/TPB, assumptions that might usefully be challenged by competing models with multidimensional constructs. Finally, statistical power and sample size should be considered for both approaches. Inattention to any of these aspects of analysis threatens the validity of TRA/TPB research.
Role of Mycobacterium tuberculosisCopper-Zinc Superoxide Dismutase

ABSTRACT Superoxide dismutases (SODs) play an important role in protection against oxidative stress and have been shown to contribute to the pathogenicity of many bacterial species. To determine the function of the mycobacterial copper and zinc-cofactored SOD (CuZnSOD), we constructed and characterized Mycobacterium tuberculosisand Mycobacterium bovis BCG CuZnSOD null mutants. Both strains were more sensitive to superoxides and hydrogen peroxide than were their respective parental strains. The survival of M. bovis BCG in unstimulated as well as activated mouse bone marrow-derived macrophages was not affected by the loss of CuZnSOD. The survival of CuZnSOD deficient-M. tuberculosis in guinea pig tissues was comparable to that of its parental strain. These results indicate that the mycobacterial CuZnSOD is not essential for intracellular growth within macrophages and does not detectably contribute to the pathogenicity of M. tuberculosis.
Women and Gender: A Feminist Psychology

Introduction to a feminist psychology of women approaches to understanding girl and woman the meanings of difference - sex, gender and cognitive abilities images of women doing gender - sex, status and power biological aspects of sex and gender becoming gendered - childhood becoming woman - puberty and adolescence sex, love and romance commitments - women and long-term relationships mothering work and achievement midlife and beyond violence against women gender and psychological disorder summing up.
Ethnic Diversity and Creativity in Small Groups

There is a growing belief among managers that ethnic diversity, when well managed, can provide organizations with certain competitive advantages. But the belief in this value-inl diversity hypothesis rests largely on anecdotal rather than empirical evidence. Results are reported ofa controlled experimental study that compares the performance on a brainstorm ing task between groups composed of all Anglo-Americans with groups composed ofAnglo-, Asian, African, and Hispanic Americans. The particular brainstorming task used-The Tourist Problem-was chosenfor its relevancefordiversity along the dimension of ethnicity. The ideas produced by the ethnically diverse groups were judged to be of higher quality-more effective andfeasible-than the ideas produced by the homogeneous groups. Members of homogeneous groups reported marginally more attraction to their groups than did members of diverse oroups. Directions for future research with respect to the degree of diversity, the nature of the task, and group process are discussed.
Inhibition of Growth, Synthesis, and Permeability in Neurospora crassa by Phenethyl Alcohol

Lester, Gabriel (Reed College, Portland, Ore.). Inhibition of growth, synthesis, and permeability in Neurospora crassa by phenethyl alcohol. J. Bacteriol. 90: 29–37. 1965. —Inhibition of the growth of Neurospora crassa in still culture was detected at 0.05% and was complete at a level of 0.2% phenethyl alcohol (PEA). Benzyl alcohol was less inhibitory, and 3-phenyl-1-propanol and phenol were more inhibitory, than PEA; benzylamine and phenethylamine were less inhibitory than the analogous hydroxylated compounds. Inhibition by PEA was not reversed by synthetic mixtures of purines and pyrimidines or vitamins, or by casein digests, yeast extract, or nutrient broth. The germination of conidia was inhibited by PEA, but after an exposure of 8.5 hr no loss of viability was observed. The addition of PEA to growing shake cultures caused a simultaneous inhibition of growth and of the syntheses of ribonucleic and deoxyribonucleic acids and protein; the relationships of these compounds to mycelial dry weight and to one another were constant in growing mycelia, and PEA did not significantly affect these relationships. PEA partially inhibited the uptake of glucose, but severely restricted the accumulation of l-leucine, l-tryptophan, or α-aminoisobutyric acid in germinated conidia. The efflux of α-aminoisobutyric acid from germinated conidia was somewhat enhanced by PEA, but this effect was not so pronounced as the (complete) inhibition of α-aminoisobutyric acid accumulation by PEA. It is suggested that PEA affects primarily the initial influx of α-aminoisobutyric acid rather than the subsequent retention of α-aminoisobutyric acid.
The Impact of a Learning Culture on Organisational Change in Regional SMEs.

This paper explores the impact of a learning culture on organisational change in small to medium-sized regional manufacturing enterprises following a review of the related literature, and a qualitative study of 10 manufacturing SMEs in the Riverina region of New South Wales. The research confirmed that key learning culture factors as identified in the literature were significant in the regional manufacturing firms studied. These included a strong commitment to a learning culture within the organisation, employee involvement in the development of the learning culture, demonstrating the tangible benefits of a learning culture to senior managers, and strong leadership support for organisational learning.
Effect of a syphilis control programme on pregnancy outcome in Nairobi, Kenya

Objectives: To assess the impact of a syphilis control programme of pregnant women on pregnancy outcome in Kenya. Method: Women who came to deliver to Pumwani Maternity Hospital (PMH) between April 1997 and March 1998 were tested for syphilis. Reactive rapid plasma reagin (RPR) tests were titrated and confirmed with treponema haemagglutination test (TPHA). Equal numbers of RPR and TPHA negative women were enrolled. Antenatal syphilis screening and treatment history were examined from the antenatal cards. Results: Of 22 466 women giving birth, 12 414 (55%) were tested for syphilis. Out of these, 377 (3%) were RPR reactive of whom 296 were confirmed by TPHA. Syphilis seroreactive women had a more risky sexual behaviour and coexistent HIV antibody positivity; 26% were HIV seropositive compared with 11% among syphilis negative mothers. The incidence of adverse obstetric outcome defined as low birth weight and stillbirth, was 9.5%. Syphilis seropositive women had a higher risk for adverse obstetric outcome (OR 4.1, 95% CI 2.4–7.2). Antenatal treatment of RPR reactive women significantly improved pregnancy outcome but the risk of adverse outcome remained 2.5-fold higher than the risk observed in uninfected mothers. Conclusions: These data confirm the adverse effect of syphilis on pregnancy outcome. This study also shows the efficacy of antenatal testing and prompt treatment of RPR reactive mothers on pregnancy outcome.
Learning Musical Contour on a Tabletop

Many successful tabletop applications for music making have been developed, and the technology has been investigated from different perspectives. Yet, to date, despite optimistic claims regarding their potential as learning tools, their role in helping people to explore, acquire, and rea- son about musical concepts has been sparsely researched. We have developed an exploratory study around a simple tabletop application that allows people to make music using a visual representation of melodic contour. Our aim is to understand whether and how such system might help peo- ple to reason about music in terms of contour while at the same time affording an enjoyable music making experience to musically untrained people. Our findings suggest that the system has potential as a learning tool, especially for beginners, but tutoring is still necessary to acquire, use, and express concepts precisely.
Voluntary Work for Adults with Mental Health Problems: A Route to Inclusion? A Review of the Literature

Voluntary work is seen as a key component of promoting mental health through social inclusion. For many years, occupational therapists have worked in partnership with voluntary organisations to facilitate access for service users to voluntary placements. Yet there is little published evidence to support this aspect of occupational therapy or to indicate specific successful strategies, especially in establishing successful placements beyond mental health services. This review examined the existing evidence, discussing the implications for occupational therapy. The findings indicate a need for further research to ascertain the benefits of volunteering, the barriers and the ways to improve access for people with mental health problems. Occupational therapists, with their unique synthesis of knowledge and skills concerning occupation, enabling and client-centred practice (Townsend and Wilcock 2004), should be well placed to be able to respond to these issues, yet the literature does not provide evidence that they have risen to the challenge.
Distinguishing Eosinophilic Esophagitis in Pediatric Patients: Clinical, Endoscopic, and Histologic Features of An Emerging Disorder

Goals To determine the clinical, endoscopic, and histologic criteria that distinguish children with eosinophilic esophagitis (EE) from those with non-EE diagnoses. Background EE is a disease of escalating incidence. Distinguishing children with EE from those with non-EE diagnosis can be difficult before endoscopy. Study A retrospective case-control study was performed for children with any degree of esophageal eosinophilic inflammation who underwent esophageal biopsy at Children's Hospital San Diego from January 1998 to December 2002. A database containing children who met histologic criteria for EE and an equivalent number of children who had milder esophageal eosinophilia (non-EE patients) was created to compare the 2 groups. Results The number of EE cases increased from 15 in 1998 to 35 in 2002. EE patients were predominantly school-aged boys; 5 of 102 were suspected to have EE before biopsy. Although EE and non-EE patients complained of vomiting and abdominal pain at equivalent rates, EE patients were 3 times more likely to complain of dysphagia [odds ratio (OR)=3.11, 95% confidence interval (CI) 1.55-6.65] and twice as likely to have stricture formation (OR=2.43, 95% CI 0.72-11.75). On endoscopy, patients with EE were 19-times more likely than non-EE patients to have endoscopic abnormalities (OR=19, 95% CI 9.0-45.88). Histologically, EE patients were more likely to have basal zone hyperplasia and degranulated eosinophils (OR=45 and 157, respectively). Conclusions We demonstrate that school-aged children, particularly boys, who complain of dysphagia should raise the index of suspicion for EE. We also suggest that EE-associated strictures are more common than peptic strictures in children.
Theory of Change and the Effective Use of Management Science.

Dale E. Zand and Richard E. Sorensen A theory of social change formulated by Kurt Lewin was used as a framework to investigate conditions in the successful application of management science. Several hypotheses about change are derived, and questionnaires developed to assess forces affecting change. A sample of 154 management scientists provided information about successful and unsuccessful change projects. Successful projects were found to have a preponderance of favorable forces in each of three phases of change: unfreezing, moving, and refreezing. The research also suggested that favorable and unfavorable forces in each phase of change were not simple opposites. The study indicated that many forces may affect the success of a change; such as, recognition by management of the need for change, the openness of management about its difficulties, and their confidence in the management scientist, the participation of management in gathering data and choosing a solution, the efforts of management scientists to reinforce the new behavior of management, the measurability of results, and the involvement of top management. Although the change efforts studied in this research were projects in management science, the findings seem relevant and generalizable to other change efforts.
Flexible visual information representation in human parietal cortex

In many everyday activities, we must visually process multiple objects embedded in complex real world scenes. Our visual system can flexibly extract behaviorally relevant visual information from such scenes, even though it has a severely limited processing capacity. This dissertation proposes that human superior intra-­‐parietal sulcus (IPS) plays a central role in this flexible visual information processing. In Chapter 1, using functional magnetic resonance imaging (fMRI) with univariate analysis, I found that distractor processing in superior IPS was attenuated when target locations were known in advance. In Chapter 2, using multi-­‐voxel pattern analysis (MVPA), I showed that superior IPS encoded object shapes, but only when such information was required by task. In Chapter 3, I showed that, given a set of perceptually distinct, but semantically grouped visual inputs, superior IPS could represent abstract object identity. The neural similarity of identities in superior IPS significantly correlated with perceived similarity between identities, confirming the representation in this region indeed reflected identity. Taken together, these results suggest that human superior IPS encodes a wide range of visual information, from simple features to abstract identities, in a task-­‐dependent manner, enabling flexible goal-­‐directed visual information processing in the human brain.