Miracle-dz/UniFAR-FTUs huggingface dataset:
Beat synchronization predicts neural speech encoding and reading readiness in preschoolers

Significance Sensitivity to fine timing cues in speech is thought to play a key role in language learning, facilitating the development of phonological processing. In fact, a link between beat synchronization, which requires fine auditory–motor synchrony, and language skills has been found in school-aged children, as well as adults. Here, we show this relationship between beat entrainment and language metrics in preschoolers and use beat synchronization ability to predict the precision of neural encoding of speech syllables in these emergent readers. By establishing links between beat keeping, neural precision, and reading readiness, our results provide an integrated framework that offers insights into the preparative biology of reading. Temporal cues are important for discerning word boundaries and syllable segments in speech; their perception facilitates language acquisition and development. Beat synchronization and neural encoding of speech reflect precision in processing temporal cues and have been linked to reading skills. In poor readers, diminished neural precision may contribute to rhythmic and phonological deficits. Here we establish links between beat synchronization and speech processing in children who have not yet begun to read: preschoolers who can entrain to an external beat have more faithful neural encoding of temporal modulations in speech and score higher on tests of early language skills. In summary, we propose precise neural encoding of temporal modulations as a key mechanism underlying reading acquisition. Because beat synchronization abilities emerge at an early age, these findings may inform strategies for early detection of and intervention for language-based learning disabilities.
Tracheal Occlusion Conditioning in Conscious Rats Modulates Gene Expression Profile of Medial Thalamus

The thalamus may be the critical brain area involved in sensory gating and the relay of respiratory mechanical information to the cerebral cortex for the conscious awareness of breathing. We hypothesized that respiratory mechanical stimuli in the form of tracheal occlusions would modulate the gene expression profile of the thalamus. Specifically, it was reasoned that conditioning to the respiratory loading would induce a state change in the medial thalamus consistent with a change in sensory gating and the activation of molecular pathways associated with learning and memory. In addition, respiratory loading is stressful and thus should elicit changes in gene expressions related to stress, anxiety, and depression. Rats were instrumented with inflatable tracheal cuffs. Following surgical recovery, they underwent 10 days (5 days/week) of transient tracheal occlusion conditioning. On day 10, the animals were sacrificed and the brains removed. The medial thalamus was dissected and microarray analysis of gene expression performed. Tracheal obstruction conditioning modulated a total of 661 genes (p < 0.05, log2 fold change ≥0.58), 250 genes were down-regulated and 411 up-regulated. There was a significant down-regulation of GAD1, GAD2 and HTR1A, HTR2A genes. CCK, PRKCG, mGluR4, and KCJN9 genes were significantly up-regulated. Some of these genes have been associated with anxiety and depression, while others have been shown to play a role in switching between tonic and burst firing modes in the thalamus and thus may be involved in gating of the respiratory stimuli. Furthermore, gene ontology and pathway analysis showed a significant modulation of learning and memory pathways. These results support the hypothesis that the medial thalamus is involved in the respiratory sensory neural pathway due to the state change of its gene expression profile following repeated tracheal occlusions.
Reduction of Neuromuscular Activity Is Required for the Rescue of Motoneurons from Naturally Occurring Cell Death by Nicotinic-Blocking Agents

Spinal motoneurons (MNs) in the chick embryo undergo programmed cell death coincident with the establishment of nerve–muscle connections and the onset of synaptic transmission at the neuromuscular junction. Chronic treatment of embryos during this period with nicotinic acetylcholine receptor (nAChR)-blocking agents [e.g., curare or α-bungarotoxin (α-BTX)] prevents the death of MNs. Although this rescue effect has been attributed previously to a peripheral site of action of the nAChR-blocking agents at the neuromuscular junction (NMJ), because nAChRs are expressed in both muscle and spinal cord, it has been suggested that the rescue effect may, in fact, be mediated by a direct central action of nAChR antagonists. By using a variety of different nAChR-blocking agents that target specific muscle or neuronal nAChR subunits, we find that only those agents that act on muscle-type receptors block neuromuscular activity and rescue MNs. However, paralytic, muscular dysgenic mutant chick embryos also exhibit significant increases in MN survival that can be further enhanced by treatment with curare or α-BTX, suggesting that muscle paralysis may not be the sole factor involved in MN survival. Taken together, the data presented here support the argument that, in vivo, nAChR antagonists promote the survival of spinal MNs primarily by acting peripherally at the NMJ to inhibit synaptic transmission and reduce or block muscle activity. Although a central action of these agents involving direct perturbations of MN activity may also play a contributory role, further studies are needed to determine more precisely the relative roles of central versus peripheral sites of action in MN rescue.
Partners versus strangers: random rematching in public goods experiments

This chapter was originally published in the book Handbook of Experimental Economics Results. The copy attached is provided by Elsevier for the author’s benefit and for the benefit of the author’s institution, for noncommercial research, and educational use. This includes without limitation use in instruction at your institution, distribution to specific colleagues, and providing a copy to your institution’s administrator.
Calibration for time domain propagation constant measurements on power cables

A method has been developed for characterising the wave propagation properties of medium voltage (MV) power cables. The technique is based on time and frequency domain analysis of short pulse propagation. Particular attention is paid to the measurement calibration, as samples with arbitrary characteristic impedances cause significant multiple reflections in the test set-up.
Structural Adaptation of Workflows Supported by a Suspension Mechanism stand by Case-Based Reasoning

Collaborative, long-term processes with changing requirements occur in several domains. In design and manufacturing, we observed the following particular characteristics: the process models can be huge and contain longsome decisions while the time to market is tight. Furthermore, different types of products have to be considered. In this paper, we present an approach of new, flexible workflow technology that provides a solution for this: The ongoing workflows can be adapted by means of late-planning and ad-hoc changes. A suspension mechanism allows the workflow designers to modify parts of a workflow while the remainder of the workflow can continue to be executed. A case-based reasoning approach supports the reuse of past experience for this.
Effect of Probiotics on the Treatment of Children with Atopic Dermatitis

Background Atopic dermatitis, a chronic recurrent disease, is frequently encountered in clinical practice. In the last 30 years, the prevalence of atopic dermatitis has rapidly increased due to industrialization. Therefore, there have been attempts in recent years to find new ways of treating and preventing atopic dermatitis. Objective In this double-blind, randomized, placebo-controlled study, a combination of Bifidobacterium bifidum, Lactobacillus acidophilus, Lactobacillus casei, and Lactobacillus salivarius strains were evaluated in the treatment of atopic dermatitis in pediatric patients. Methods Forty pediatric patients (23 males and 17 females) aged 1~13 years were enrolled. One eligible individual who was approached declined to participate. The probiotic group was administered a probiotic complex containing B. bifidum, L. acidophilus, L. casei, and L. salivarius for 8 weeks. The placebo group, on the other hand, was administered skim milk powder and dextrose. All of the parameters including serum cytokines, eosinophil cationic protein), SCORing Atopic Dermatitis (SCORAD) index, and total serum immunoglobulin E (IgE) were measured in both the probiotic group and the placebo group at the end of 8 weeks. Results Probiotic intervention in pediatric atopic dermatitis patients effectively reduced the SCORAD index and serum cytokines interleukin (IL)-5, IL-6, interferon (IFN)-γ, and total serum IgE levels, but did not reduce levels of serum cytokines IL-2, IL-4, IL-10, ECP, or tumor necrosis factor-α (TNF-α) compared to the placebo group. Conclusion Our study found probiotics to be effective in reducing atopic dermatitis patients' SCORAD index, serum IL-5, IL-6, IFN-γ, and total serum IgE levels but not effective in reducing serum IL-2, IL-4, IL-10, ECP, or TNF-α levels.
Clinical and Physiological Effects of a New, Less Toxic and Less Acidic Fluid for Peritoneal Dialysis

Objective To report our first clinical experience with a new continuous ambulatory peritoneal dialysis (CAPD)fiuid (PD-Bio), which is nearly devoid of glucose degradation products and has a higher pH (6.3) than conventional peritoneal dialysis (PD) solutions, and to discuss in general terms some acute and long-term effects of conventional acidic solutions containing glucose degradation products. Design 1) Pilot study on 4 patients investigated using a modified peritoneal equilibration test (PET) and cytobiology parameters. 2) Computer simulation study, assuming that conventional acidic solutions cause vasodilatation and recruitment of capillary surface area initially (during 0–60 minutes) in a PD dwell. Patients Four stable CAPD patients were chosen in an open cross-over study. After a period of three months using conventional PD fluid, the patients were switched to three months on the new PD fluid. Results Cancer antigen 125 increased significantly, and patients with discomfort/infusion pain during the control period improved during the period with the new fluid. No significant changes were observed in mass-transfer coefficients or drained volumes with the new solution. PH in the effluent dialysis was, however, higher for PD-Bio at all times during a two-hour dwell. In the computer simulation study, a less acidic solution caused an initially lower rate of glucose dissipation and improved ultrafiltration (UF) after a four -hour dwell, as compared to a conventional PD solution. Conclusion A new, differently produced, less toxic and less acidic PD fluid (PD-Bio) seems to be better tolerated than a conventional acidic solution with respect to discomfort/infusion pain. Theoretically, neutralized solutions should show slightly improved UF profiles over conventional acidic solutions, according to the computer simulation analysis. Furthermore, it is speculated that a neutral, less acidic, less toxic fluid would cause less interstitial-mesothelial alterations and less impairment of UF capacity than conventional solutions during longterm CAPD.
Reversible control of synaptic transmission in a single gene mutant of Drosophila melanogaster

Synaptic transmission of the single gene mutant, shibirets1 (shi), of Drosophila melanogaster is reversibly blocked by elevated temperature. The presynaptic mechanism of transmission was studied in the neuromuscular junction of the dorsal longitudinal flight muscle of this mutant. It was observed that when the temperature was raised to 29 degrees C in shi flies, the amplitude of the excitatory junction potential (EJP) greatly diminished, the frequency of spontaneously released miniature excitatory junction potentials (MEJP's) was greatly reduced, and almost complete vesicle depletion was observed. These conditions were reversible if the temperature was lowered to 19 degrees C. These data suggest that the block in transmission is a result of vesicle depletion. It is suggested that depletion occurs not as a result of excessive release of transmitter but rather as a result of a block in the recycling of vesicles, which causes depletion as exocytosis (transmitter release) proceeds normally.
Voice Recognition Technology and Persons with Severe Mental Retardation and Severe Physical Impairment: Learning, Response Differentiation, and Affect

This study investigated the learning and response differentiation of a variety of voice commands that served to control environmental devices by a person who is severely mentally retarded and severely physically impaired. The contingencies between vocalization and device activation were created by a computer system with voice recognition and environmental control capabilities. Using a multiple-baseline-across-behaviors experimental design, the study shows that the subject (a) learned the cause-and-effect relationship between her voice and the resultant environmental action, (b) differentiated various vocalizations for different environmental actions, and (c) experienced positive affect when she was in control. This application represents the first time in the subject's life that she exerted independent control over her environment.
Noninvasive ventilation for treatment of acute respiratory failure in patients undergoing solid organ transplantation: a randomized trial.

CONTEXT Noninvasive ventilation (NIV) has been associated with lower rates of endotracheal intubation in populations of patients with acute respiratory failure. OBJECTIVE To compare NIV with standard treatment using supplemental oxygen administration to avoid endotracheal intubation in recipients of solid organ transplantation with acute hypoxemic respiratory failure. DESIGN AND SETTING Prospective randomized study conducted at a 14-bed, general intensive care unit of a university hospital. PATIENTS Of 238 patients who underwent solid organ transplantation from December 1995 to October 1997, 51 were treated for acute respiratory failure. Of these, 40 were eligible and 20 were randomized to each group. INTERVENTION Noninvasive ventilation vs standard treatment with supplemental oxygen administration. MAIN OUTCOME MEASURES The need for endotracheal intubation and mechanical ventilation at any time during the study, complications not present on admission, duration of ventilatory assistance, length of hospital stay, and intensive care unit mortality. RESULTS The 2 groups were similar at study entry. Within the first hour of treatment, 14 patients (70%) in the NIV group, and 5 patients (25%) in the standard treatment group improved their ratio of the PaO2 to the fraction of inspired oxygen (FIO2). Over time, a sustained improvement in PaO2 to FIO2 was noted in 12 patients (60%) in the NIV group, and in 5 patients (25%) randomized to standard treatment (P = .03). The use of NIV was associated with a significant reduction in the rate of endotracheal intubation (20% vs 70%; P = .002), rate of fatal complications (20% vs 50%; P = .05), length of stay in the intensive care unit by survivors (mean [SD] days, 5.5 [3] vs 9 [4]; P = .03), and intensive care unit mortality (20% vs 50%; P = .05). Hospital mortality did not differ. CONCLUSIONS These results indicate that transplantation programs should consider NIV in the treatment of selected recipients of transplantation with acute respiratory failure.
Ieee Transactions on Image Processing Exact Feature Extraction Using Finite Rate of Innovation Principles with an Application to Image Super-resolution Edics: Mrp-wavl (wavelets), Isr-rgst (registration / Alignment) and Isr-supr (super-resolution)

The accurate registration of multiview images is of central importance in many advanced image processing applications. Image super-resolution, for example, is a typical application where the quality of the super-resolved image is degrading as registration errors increase. Popular registration methods are often based on features extracted from the acquired images. The accuracy of the registration is in this case directly related to the number of extracted features and to the precision at which the features are located: images are best registered when many features are found with a good precision. However, in low-resolution images, only a few features can be extracted and often with a poor precision. By taking a sampling perspective, we propose in this paper new methods for extracting features in low resolution images in order to develop efficient registration techniques. We consider in particular the sampling theory of signals with finite rate of innovation [10] and show that some features of interest for registration can be retrieved perfectly in this framework, thus allowing an exact registration. We also demonstrate through simulations that the sampling model which enables the use of finite rate of innovation principles is well-suited for modeling the acquisition of images by a camera. Simulations of image registration and image super-resolution of artificially sampled images are first presented, analyzed and compared to traditional techniques. We finally present favorable experimental results of super-resolution of real images acquired by a digital camera available on the market.
Use of fluoroquinolones for intracellular pathogens.

Current microbiologic techniques (determinations of minimal inhibitory and/or microbicidal concentrations) are unable to delineate the true role of anti-infectious drugs in the treatment of human infections due to intracellular pathogens. The prediction and evaluation of the efficacy of quinolones against intracellular pathogens requires information on four different steps. (1) Quinolones should be able to penetrate phagocytes; intramacrophagic concentration is highly dependent on serum pharmacokinetics; finally, the best quinolone should have the longest serum half-life and reach highest maximum serum concentrations. (2) The evaluation of antibacterial activity requires an adequate cellular model (e.g., multiplication of Legionella pneumophila within human monocyte-derived macrophages). (3) The prediction of drug efficacy requires an experimental animal model. (4) Clinical trials in human disease are necessary. This stage is difficult when the evaluation concerns severe infectious diseases because the rarity of these diseases makes random clinical trials difficult. In this paper we describe methodologies for assessing the efficacy of quinolones against intracellular bacterial pathogens with a particular focus on Legionella pneumophila.
Temporal multimodal fusion for video emotion classification in the wild

This paper addresses the question of emotion classification. The task consists in predicting emotion labels (taken among a set of possible labels) best describing the emotions contained in short video clips. Building on a standard framework – lying in describing videos by audio and visual features used by a supervised classifier to infer the labels – this paper investigates several novel directions. First of all, improved face descriptors based on 2D and 3D Convolutional Neural Networks are proposed. Second, the paper explores several fusion methods, temporal and multimodal, including a novel hierarchical method combining features and scores. In addition, we carefully reviewed the different stages of the pipeline and designed a CNN architecture adapted to the task; this is important as the size of the training set is small compared to the difficulty of the problem, making generalization difficult. The so-obtained model ranked 4th at the 2017 Emotion in the Wild challenge with the accuracy of 58.8 %.
Organization Science

T wo competing predictions about the effect of status on performance appear in the organizational theory and sociological literatures. On one hand, various researchers have asserted that status improves performance. This line of work emphasizes tangible and intangible resources that accrue to occupants of high-status positions and therefore pictures status as an asset. On the other hand, a second stream of research argues that status instead diminishes performance. This alternative line of work emphasizes complacency and distraction as deleterious processes that plague occupants of high-status positions and thus portrays status as a liability. Which of these two perspectives best characterizes the actual performance of individuals in a competitive setting? And are they in any way reconcilable? In this paper, we summarize these two perspectives and test them in two empirical settings: the Professional Golf Association (PGA) and the National Association for Stock Car Auto Racing (NASCAR). Using panel data on the PGA Tour, we model golfers' strokes from par in each competition as a function of their status in the sport. Using similar data on NASCAR's Winston Cup Series, we model drivers' speed in the qualifying round as a function of their status in the sport. We find curvilinear effects of status in both contexts. Performance improves with status until a very high level of status is reached, after which performance wanes. This result not only concurs with the view that status brings tangible and intangible resources but also provides empirical support for the contention that status fosters dispositions and behaviors that ultimately erode performance.
On the dynamics of cortical development: synchrony and synaptic self-organization

We describe a model for cortical development that resolves long-standing difficulties of earlier models. It is proposed that, during embryonic development, synchronous firing of neurons and their competition for limited metabolic resources leads to selection of an array of neurons with ultra-small-world characteristics. Consequently, in the visual cortex, macrocolumns linked by superficial patchy connections emerge in anatomically realistic patterns, with an ante-natal arrangement which projects signals from the surrounding cortex onto each macrocolumn in a form analogous to the projection of a Euclidean plane onto a Möbius strip. This configuration reproduces typical cortical response maps, and simulations of signal flow explain cortical responses to moving lines as functions of stimulus velocity, length, and orientation. With the introduction of direct visual inputs, under the operation of Hebbian learning, development of mature selective response “tuning” to stimuli of given orientation, spatial frequency, and temporal frequency would then take place, overwriting the earlier ante-natal configuration. The model is provisionally extended to hierarchical interactions of the visual cortex with higher centers, and a general principle for cortical processing of spatio-temporal images is sketched.