Miracle-dz/UniFAR-FTUs huggingface dataset:
Ulcerative Colitis and Colorectal Cancer: Aneuploidy and Implications for Improved Screening

Patients with ulcerative colitis (UC) have a significantly increased lifetime risk for the development of colorectal carcinomas. Ulcerative colitis can therefore be considered a bona fide premalignant condition. It is therefore recommended that patients with UC participate in surveillance programs to screen for early signs of malignancy. However, reliable endoscopic sampling and histopathological evaluation is difficult. The diagnostic dilemma is underlined by the fact that despite screening programs about half of the patients with an ulcerative colitis-associated carcinoma (UCC) are diagnosed at an already advanced tumor stage reflecting poor prognosis. For these reasons, it should be obvious that additional markers with high prognostic impact in the individual risk assessment are of high clinical demand. While genetic and genomic changes during carcinogenesis have been thoroughly studied in sporadic colorectal cancers, less is known about the development of UCCs. This chapter will therefore focus on the role of genomic instability during colitis-associated carcinogenesis and how ploidy assessment might help to improve individual risk stratification regarding imminent colorectal cancer risk and survival prognosis.
Requirements for Large Eddy Simulation Computations of Variable-Speed Power Turbine Flows

Variable-speed power turbines (VSPTs) operate at low Reynolds numbers and with a wide range of incidence angles. Transition, separation, and the relevant physics leading to them are important to VSPT flow. Higher fidelity tools such as large eddy simulation (LES) may be needed to resolve the flow features necessary for accurate predictive capability and design of such turbines. A survey conducted for this report explores the requirements for such computations. The survey is limited to the simulation of two-dimensional flow cases and endwalls are not included. It suggests that a grid resolution necessary for this type of simulation to accurately represent the physics may be of the order of Delta(x)+=45, Delta(x)+ =2 and Delta(z)+=17. Various subgrid-scale (SGS) models have been used and except for the Smagorinsky model, all seem to perform well and in some instances the simulations worked well without SGS modeling. A method of specifying the inlet conditions such as synthetic eddy modeling (SEM) is necessary to correctly represent the inlet conditions.
Perceptions, Uses of, and Interests in Complementary Health Care Approaches in Depressed Pregnant Women

Depression affects up to 23% of pregnant women and is associated with adverse physical/mental health outcomes for both the mother and baby. Depressed pregnant women may be more likely to engage in unhealthy lifestyle behaviors that contribute to an increased risk for chronic disease. Little is known regarding depressed pregnant women’s perceptions, uses of, and interests in complementary health approaches. Study participants (mean age 28.7 ± 6.8; n = 1032) included pregnant women ≥8 weeks gestation who responded to a survey assessing physical and mental health and wellness practices. Of those completing the survey, depressed pregnant women (n = 272) had significantly higher levels of anxiety (P < .001) and stress (P < .001) and had poorer sleep quality (P < .001), mindfulness (P < .001), and social support (P < .001) compared to nondepressed pregnant women (n = 760). A majority (84%) of depressed pregnant women would consider using a complementary health approach for weight and/or stress management during pregnancy, and more than 50% were interested in yoga.
Migraine and the risk of cardiovascular and cerebrovascular events: a meta-analysis of 16 cohort studies including 1 152 407 subjects

Objectives To perform an updated meta-analysis to evaluate the long-term cardiovascular and cerebrovascular outcomes among migraineurs. Setting A meta-analysis of cohort studies performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Data sources The MEDLINE, Web of Science and Cochrane Central Register of Controlled Trials databases were searched for relevant articles. Participants A total of 16 cohort studies (18 study records) with 394 942 migraineurs and 757 465 non-migraineurs were analysed. Primary and secondary outcome measures Major adverse cardiovascular and cerebrovascular events (MACCE), stroke (ie, ischaemic, haemorrhagic or non-specified), myocardial infarction (MI) and all-cause mortality. The outcomes were reported at the longest available follow-up. Data analysis Summary-adjusted hazard ratios (HR) were calculated by random-effects Der-Simonian and Liard model. The risk of bias was assessed by the Newcastle-Ottawa Scale. Results Migraine was associated with a higher risk of MACCE (adjusted HR 1.42, 95% confidence interval [CI] 1.26 to 1.60, P<0.001, I2=40%) driven by a higher risk of stroke (adjusted HR 1.41, 95% CI 1.25 to 1.61, P<0.001, I2=72%) and MI (adjusted HR 1.23, 95% CI 1.03 to 1.43, P=0.006, I2=59%). There was no difference in the risk of all-cause mortality (adjusted HR 0.93, 95% CI 0.78 to 1.10, P=0.38, I2=91%), with a considerable degree of statistical heterogeneity between the studies. The presence of aura was an effect modifier for stroke (adjusted HR aura 1.56, 95% CI 1.30 to 1.87 vs adjusted HR no aura 1.11, 95% CI 0.94 to 1.31, P interaction=0.01) and all-cause mortality (adjusted HR aura 1.20, 95% CI 1.12 to 1.30 vs adjusted HR no aura 0.96, 95% CI 0.86 to 1.07, Pinteraction<0.001). Conclusion Migraine headache was associated with an increased long-term risk of cardiovascular and cerebrovascular events. This effect was due to an increased risk of stroke (both ischaemic and haemorrhagic) and MI. There was a moderate to severe degree of heterogeneity for the outcomes, which was partly explained by the presence of aura. PROSPERO registration number CRD42016052460.
Dosimetric evaluation of Plastic Water Diagnostic Therapy

High‐precision radiotherapy planning and quality assurance require accurate dosimetric and geometric phantom measurements. Phantom design requires materials with mechanical strength and resilience, and dosimetric properties close to those of water over diagnostic and therapeutic ranges. Plastic Water Diagnostic Therapy (PWDT: CIRS, Norfolk, VA) is a phantom material designed for water equivalence in photon beams from 0.04 MeV to 100 MeV; the material has also good mechanical properties. The present article reports the results of computed tomography (CT) imaging and dosimetric studies of PWDT to evaluate the suitability of the material in CT and therapy energy ranges. We characterized the water equivalence of PWDT in a series of experiments in which the basic dosimetric properties of the material were determined for photon energies of 80 kVp, 100 kVp, 250 kVp, 4 MV, 6 MV, 10 MV, and 18 MV. Measured properties included the buildup and percentage depth dose curves for several field sizes, and relative dose factors as a function of field size. In addition, the PWDT phantom underwent CT imaging at beam qualities ranging from 80 kVp to 140 kVp to determine the water equivalence of the phantom in the diagnostic energy range. The dosimetric quantities measured with PWDT agreed within 1.5% of those determined in water and Solid Water (Gammex rmi, Middleton, WI). Computed tomography imaging of the phantom was found to generate Hounsfield numbers within 0.8% of those generated using water. The results suggest that PWDT material is suitable both for regular radiotherapy quality assurance measurements and for intensity‐modulated radiation therapy (IMRT) verification work. Sample IMRT verification results are presented. PACS number: 87.53Dq
Flexural, Impact Properties and Sem Analysis of Bamboo and Glass Fiber Reinforced Polyester Hybrid Composites

The Flexural, Impact properties and Scanning electron microscope analysis of Bamboo/glass fibers Reinforced polyester Hybrid composites were studied. The effect of alkali treatment of the bamboo fibers on these properties was also studied. It was observed that the Flexural, impact properties of the hybrid composite increase with glass fiber content. These properties found to be higher when alkali treated bamboo fibers were used in the hybrid composites. The elimination of amorphous hemi-cellulose with alkali treated leading to higher crystallinity of the bamboo fibers with alkali treatment may be responsible for these observations. The author investigated the interfacial bonding between Glass/Bamboo reinforced polyester composites. The effect of alkali treatment on the bonding between Glass/Bamboo composites was also studied.
Inhibition of overexpression of Giα proteins and nitroxidative stress contribute to sodium nitroprusside‐induced attenuation of high blood pressure in SHR

We earlier showed that vascular smooth muscle cells (VSMC) from spontaneously hypertensive rats (SHR) exhibit enhanced expression of Giα proteins which was attributed to the decreased levels of nitric oxide (NO), because elevation of the intracellular levels of NO by NO donors; sodium nitroprusside (SNP) and S‐Nitroso‐N‐acetyl‐DL‐penicillamine (SNAP), attenuated the enhanced expression of Giα proteins. Since the enhanced expression of Giα proteins is implicated in the pathogenesis of hypertension, the present study was undertaken to investigate if treatment of SHR with SNP could also attenuate the development of high blood pressure (BP) and explore the underlying molecular mechanisms. Intraperitoneal injection of SNP at a concentration of 0.5 mg/kg body weight twice a week for 2 weeks into SHR attenuated the high blood pressure by about 80 mmHg without affecting the BP in WKY rats. SNP treatment also attenuated the enhanced levels of superoxide anion (O2−), hydrogen peroxide (H2O2), peroxynitrite (ONOO−), and NADPH oxidase activity in VSMC from SHR to control levels. In addition, the overexpression of different subunits of NADPH oxidase; Nox‐1, Nox‐2, Nox‐4, P22phox, and P47phox, and Giα proteins in VSMC from SHR were also attenuated by SNP treatment. On the other hand, SNP treatment augmented the decreased levels of intracellular NO, eNOS, and cGMP in VSMC from SHR. These results suggest that SNP treatment attenuates the development of high BP in SHR through the elevation of intracellular levels of cGMP and inhibition of the enhanced levels of Giα proteins and nitroxidative stress.
Significance of Streptococcus gallolyticus subsp. gallolyticus Association With Colorectal Cancer

Streptococcus gallolyticus subsp. gallolyticus Sgg (formerly known as S. bovis type I) is the main causative agent of septicemia and infective endocarditis (IE) in elderly and immunocompromised persons. It belongs to the few opportunistic bacteria, which have been strongly associated to colorectal cancer (CRC). A literature survey covering a period of 40 years (1970–2010) revealed that 65% of patients diagnosed with an invasive Sgg infection had a concomitant colorectal neoplasia. Sgg is associated mainly with early adenomas and may thus constitute an early marker for CRC screening. Sgg has been described as a normal inhabitant of the rumen of herbivores and in the digestive tract of birds. It is more rarely detected in human intestinal tract (2.5–15%). Recent molecular analyses indicate possible zoonotic transmission of Sgg. Thanks to the development of a genetic toolbox and to comparative genomics, a number of factors that are important for Sgg pathogenicity have been identified. This review will highlight the role of Sgg pili in host colonization and how their phase-variable expression contributes to mitigate the host immune responses and finally their use as serological diagnostic tool. We will then present experimental data addressing the core question whether Sgg is a cause or consequence of CRC. We will discuss a few recent studies examining the etiological versus non-etiological participation of Sgg in colorectal cancer with the underlying mechanisms.
Precursors of logical reasoning in preverbal human infants

The infant as philosopher Visual behaviors, such as a shift in one's gaze or a prolonged stare, can be diagnostic of internal thoughts. Cesana-Arlotti et al. used these measures to demonstrate that preverbal infants can formulate a logical structure called a disjunctive syllogism (see the Perspective by Halberda). That is, if A or B is true, and A is false, then B must be true. Presenting infants with scenes where the outcome revealed B to be false evoked looks of surprise. Science, this issue p. 1263; see also p. 1214 The development of logical reasoning rekindles debate about the contributions of language to thinking. Infants are able to entertain hypotheses about complex events and to modify them rationally when faced with inconsistent evidence. These capacities suggest that infants can use elementary logical representations to frame and prune hypotheses. By presenting scenes containing ambiguities about the identity of an object, here we show that 12- and 19-month-old infants look longer at outcomes that are inconsistent with a logical inference necessary to resolve such ambiguities. At the moment of a potential deduction, infants’ pupils dilated, and their eyes moved toward the ambiguous object when inferences could be computed, in contrast to transparent scenes not requiring inferences to identify the object. These oculomotor markers resembled those of adults inspecting similar scenes, suggesting that intuitive and stable logical structures involved in the interpretation of dynamic scenes may be part of the fabric of the human mind.
Impact of Turmeric addition on the Properties of Paneer, Prepared from different types of Milk

A study was conducted to evaluate the properties of turmeric incorporated paneer prepared from different types of milk, i.e. cow milk, buffalo milk and mix milk. In the first part of the study, different types of milks are procured from the local market and paneer is prepared with the addition of turmeric. Turmeric was incorporated in the product at the rate of 0.0 (control) and 0.6 for samples i.e., 0.6 % by weight of expected yield of paneer after heat treatment of milk but before addition of coagulant. In the next part the samples are packed into an aluminium foil and kept in different temperatures i.e. room temperature and in refrigerated temperature. The prepared samples of paneer were subjected to sensory evaluation when fresh and after the interval and during storage for 3 days at room temperature(27±1 °C) and for 15 days refrigerated temperature(below 5 0 C). During this period of storage different tests, such as sensory evaluation, texture profile analysis and safety study (chemical analysis and microbial analysis) were conducted. The samples of paneer with 0.6 % turmeric by weight of expected yield of paneer remain acceptable up to 15 days on storage at refrigerated temperature. The present study entailed to conclude that addition of turmeric in paneer prepared from either cow milk, buffalo milk or mix milk at the rate greater than 0.6 % by weight of expected yield of paneer results into sharp decline in sensory score and texture of paneer but it is still acceptable and safe for usage . Addition of turmeric at the rate of 0.6 % by weight of expected yield of paneer and packed in aluminium foil extends the shelf life of paneer up to 15 days on storage at refrigerated temperature(below 5 0 C).
GDV1 induces sexual commitment of malaria parasites by antagonizing HP1-dependent gene silencing

Sexual development in Plasmodium Malaria-causing parasites (Plasmodium) have complex life histories in the tissues of humans. For the most part, the parasites focus their efforts on replication within the human host cells. However, occasionally, some replicating cells release gametes into the bloodstream, which are picked up by biting mosquitoes. Filarsky et al. discovered that the Plasmodium parasite keeps the production of gametes under tight epigenetic control using heterochromatin protein 1 (HP1). Plasmodium gametocytogenesis is initiated when HP1 is evicted from upstream of gamete-specific genes by gametocyte development 1 (GDV1) protein. GDV1 is in turn regulated by its antisense RNA. What triggers GDV1 expression remains unclear. Elucidating this pathway could provide a target for interrupting malaria transmission. Science, this issue p. 1259 Plasmodium replication is interrupted for gamete production by eviction of a heterochromatin binding protein upstream of the relevant genes. Malaria is caused by Plasmodium parasites that proliferate in the bloodstream. During each replication cycle, some parasites differentiate into gametocytes, the only forms able to infect the mosquito vector and transmit malaria. Sexual commitment is triggered by activation of AP2-G, the master transcriptional regulator of gametocytogenesis. Heterochromatin protein 1 (HP1)–dependent silencing of ap2-g prevents sexual conversion in proliferating parasites. In this study, we identified Plasmodium falciparum gametocyte development 1 (GDV1) as an upstream activator of sexual commitment. We found that GDV1 targeted heterochromatin and triggered HP1 eviction, thus derepressing ap2-g. Expression of GDV1 was responsive to environmental triggers of sexual conversion and controlled via a gdv1 antisense RNA. Hence, GDV1 appears to act as an effector protein that induces sexual differentiation by antagonizing HP1-dependent gene silencing.
Corrections to traditional methods of verifying tangential‐breast 3D monitor‐unit calculations: Use of an equivalent triangle to estimate effective fields

This paper describes an innovative method for correctly estimating the effective field size of tangential‐breast fields. The method uses an “equivalent triangle” to verify intact breast tangential field monitor‐unit settings calculated by a 3D planning system to within 2%. The effects on verification calculations of loss of full scatter due to beam oblique incidence, proximity to field boundaries, and reduced scattering volumes are handled properly. The methodology is validated by comparing calculations performed by the 3D planning system with the respective verification estimates. The accuracy of this technique is established for dose calculations both with and without heterogeneity corrections. © 2003 American College of Medical Physics. PACS number(s): 87.53. – j
False vacuum inflation with Einstein gravity.

We investigate chaotic inflation models with two scalar fields, such that one field (the inflaton) rolls while the other is trapped in a false vacuum state. The false vacuum becomes unstable when the inflaton field falls below some critical value, and a first or second order transition to the true vacuum ensues. Particular attention is paid to Linde's second-order `Hybrid Inflation'; with the false vacuum dominating, inflation differs from the usual true vacuum case both in its cosmology and in its relation to particle physics. The spectral index of the adiabatic density perturbation can be very close to 1, or it can be around ten percent higher. The energy scale at the end of inflation can be anywhere between $10^{16}$\,GeV and $10^{11}$\,GeV, though reheating is prompt so the reheat temperature can't be far below $10^{11}\,$GeV. Topological defects are almost inevitably produced at the end of inflation, and if the inflationary energy scale is near its upper limit they can have significant effects. Because false vacuum inflation occurs with the inflaton field far below the Planck scale, it is easier to implement in the context of supergravity than standard chaotic inflation. That the inflaton mass is small compared with the inflationary Hubble parameter is still a problem for generic supergravity theories, but remarkably this can be avoided in a natural way for a class of supergravity models which follow from orbifold compactification of superstrings. This opens up the prospect of a truly realistic, superstring
In vivo prostate IMRT dosimetry with MOSFET detectors using brass buildup caps

The feasibility of using dual bias metal oxide semiconductor field effect transistor (MOSFET) detectors with the new hemispherical brass buildup cap for in vivo dose measurements in prostate intensity‐modulated radiotherapy (IMRT) treatments was investigated and achieved. In this work, MOSFET detectors with brass buildup caps placed on the patient's skin surface on the central axis of the individual IMRT beams are used to determine the maximum entrance dose (Dmax) from the prostate IMRT fields. A general formalism with various correction factors taken into account to predict Dmax entrance dose for the IMRT fields with MOSFETs was developed and compared against predicted dose from the treatment‐planning system (TPS). We achieved an overall accuracy of better than ±5% on all measured fields for both 6‐MV and 10‐MV beams when compared to predicted doses from the Philips Pinnacle 3 and CMS XiO TPSs, respectively. We also estimate the total uncertainty in estimation of MOSFET dose in the high‐sensitivity mode for IMRT therapy to be 4.6%. PACS numbers: 87.53Xd, 87.56Fc
A patient‐based dosimetric study of intracavitary and interstitial brachytherapy in advanced stage carcinoma of the cervix

Intracavitary brachytherapy (ICBT) and interstitial brachytherapy (IB) techniques are commonly practiced for treating carcinoma of the cervix, either alone or in combination with external beam radiotherapy. Both these brachytherapy techniques have their own advantages and limitations in terms of tumor coverage and normal tissue sparing. Limited studies have been reported comparing the dosimetric features of these two techniques, especially from a single institution. We carried out a prospective clinical dosimetric comparison between ICBT and IB for patients treated at one center to bring out the inherent dosimetric features of these to two techniques. The study was carried out on 26 patients treated with ICBT and 55 with IB using CT‐based planning. Of the 55 patients treated with IB, 27 included tandem source loading (IBT) and 28 without the tandem loading (IBWT). The high‐dose volumes covered by 200% and 180% isodose surfaces were considerably larger in ICBT as compared to IB, whereas the treated volume was larger in IB as compared to ICBT. The bladder and rectal doses were the highest in ICBT and IBWT, respectively. The larger treated volume in IB as compared to ICBT was mainly because patients with larger tumor volumes were generally considered for IB. The results also indicated that in interstitial brachytherapy, better rectal sparing was achieved by including the tandem for treatment delivery. PACS numbers: 87.53. Bn, 87.53. Jw, 87.55. D‐, 87.55. dk