Miracle-dz/UniFAR-FTUs huggingface dataset:
Spain: Timing and rates of shortening and deposition Coeval hindward- and forward-imbricating thrusting in the south-central Pyrenees,

Clear demonstrations of detailed sequences of thrust development are rare, particularly with respect to hindward-imbricating successions. Similarly, well-constrained chronologies of the timing of multiple thrust motions and associated rates of shortening are also uncommon. Along the eastern oblique ramp of the South-Central Unit (SCU) of the Pyrenees, well-exposed structural geometries and crosscutting stratigraphic packages unambiguously illustrate a sequence of break-back thrusts that developed synchronously with the growth of an adjacent duplex. The breakback sequence includes both the Sierras Marginales and Montsec thrusts: structures defining two of the major east-west partitions within the SCU. Balanced, sequentially restored structural cross sections indicate that a minimum of 7.5 km of shortening occurred within the imbricate stack. An additional 9 km of contraction was accommodated by the duplex, prior to translation of the duplex and imbricate stack to the south along a detachment within upper Eocene evaporites. Magnetic polarity stratigraphies have been used to calibrate these late Eocene to Oligocene episodes of deformation. These temporal data indicate that Sierras Marginales thrusting began in the study area -39.8 Ma and that the Montsec thrust ceased movement -36.2 Ma, yielding a mean rate of shortening of 2.1 mm/yr. Coeval shortening within the duplex was -2 . 5 mm/yr, and subsequent translation across the footwall ramp occurred at -2 . 5-4 mm/yr. Despite the partitioning of shortening into distinctively different styles of deformation, the mean rate of contraction remained steady over 4 m.y. These new chronologies indicate that the locus of large-scale thrusting did not progress systematically toward the foreland, but shifted episodically within the SCU, such that, during the late Eocene shortening, the Sierras Marginales thrust was active both prior to and south of the Montsec thrust.
Emotion work and the archaeology of consensus: the Northern Iroquoian case

Abstract In archaeology, emotion has often been thought to lie beyond the reach of responsible materialist scholarship. However, this study illustrates the central role of emotion in the formation of consensus-based political systems. In the Late Woodland longhouse societies of north-eastern North America, political alliance-building depended on emotion work – elaborated interpersonal attentions in the form of grooming, bodily adornment, smoking and gift-giving that were intended to shift the affective character of relationships and satisfy deep personal desires. Emotion work depended heavily on material things – especially wampum beads and smoking pipes – that connected individual bodies with the body politic. A crucial part of the process of building and maintaining grassroots social collectives, emotion work produced historically particular forms of power and political subjectivity. These practices can be understood as a kind of corporeal politics, one with lasting consequences for indigenous sociopolitical development in eastern North America.
Nuclear morphometry predicts disease‐free interval for clinically localized adenocarcinoma of the prostate treated with definitive radiation therapy

Men treated for prostate cancer often have unexpected outcomes despite predictive models based on stage, grade and prostate‐specific antigen (PSA). Previous results have indicated that nuclear morphometry can predict patient outcome in urologic malignancies. Application of this analytical method in prostate cancer treated with radiation therapy is limited. We have evaluated the predictive ability of nuclear morphometry in such patients. Histologic sections from 23 men with clinically localized adenocarcinoma of the prostate treated with radiation therapy were studied. Nuclear morphometric parameters were assessed using a previously described and validated system. Univariate and multivariate logistic regression analyses and a Cox proportional hazards model were used to assess the ability of nuclear morphometric parameters to predict recurrence and disease‐free interval. Ten patients had no recurrence with median follow‐up of 47.5 months, while 13 had recurrence. Gleason grade was not predictive of treatment outcome. Pre‐treatment PSA data, available for only 11 patients, were predictive of treatment outcome. Several nuclear morphometric parameters predicted recurrence, including upper quartile of suboptimal circle fit and upper quartile of feret‐diameter ratio. A prognostic factor score incorporating these 2 parameters was derived, which predicted disease‐free interval (p = 0.0014). Int. J. Cancer (Pred. Oncol.) 84:594–597, 1999. © 1999 Wiley‐Liss, Inc.
An open-label study of guanfacine extended release for traumatic stress related symptoms in children and adolescents.

OBJECTIVE The purpose of this open-label pilot study was to investigate the effectiveness and tolerability of guanfacine extended release (GXR) 1-4 mg given in the evening, on the symptoms of traumatic stress (reexperiencing, avoidance, overarousal), generalized anxiety, and functional impairment in children and adolescents with a history of traumatic stress with or without posttraumatic stress disorder (PTSD). As many of our sample had associated attention-deficit/hyperactivity disorder (ADHD) symptoms, we also assessed whether the presence of traumatic stress symptoms impaired the effectiveness of GXR in the treatment of comorbid ADHD symptoms. METHODS Participants were 19 children and adolescents 6-18 years of age, with current traumatic stress symptoms. In an 8 week open-label design, each patient's scores on parent-, child-, and clinician-reported symptom rating scales assessing traumatic stress symptoms, generalized anxiety, ADHD symptoms, functional impairment, and global symptom severity and improvement (n=17) were evaluated off and on GXR using χ(2) goodness-of-fit tests, paired t tests, and repeated measures analyses of variance (ANOVAs). To examine patterns of change in outcome measures across treatment, MPlus software was used to conduct linear growth curves modeled with individual-varying times of observation (i.e., random slopes). RESULTS Using an average GXR daily dose of 1.19 mg±0.35 mg and an average weight-adjusted daily dose of 0.03 mg/kg±0.01 mg/kg, significant differences were found on all symptom severity measures. Parent reported UCLA Reaction Index scores assessing cluster B (reexperiencing), C (avoidant), and D (overarousal) symptoms significantly improved. In the presence of PTSD symptoms, children with ADHD experienced significantly improved ADHD symptom scores, suggesting that comorbidity does not attenuate an ADHD symptom response to GXR therapy. Medication was generally well tolerated. CONCLUSIONS Within the limits of an open-label, hypothesis-generating pilot study, our results suggest that the α2A-adrenoceptor agonist GXR may have therapeutic effects in the treatment of PTSD symptoms in traumatically stressed children and adolescents. The effective dose may be lower than that found for ADHD. Our pilot study supports the need for further controlled research on the effects of GXR and other α2A-adrenoceptor agonists in pediatric disorders of traumatic stress.
Regulation of nuclear envelope permeability in cell death and survival

The nuclear pore complex (NPC) mediates macromolecular exchange between nucleus and cytoplasm. It is a regulated channel whose functional properties are modulated in response to the physiological status of the cell. Identifying the factors responsible for regulating NPC activity is crucial to understand how intracellular signaling cues are integrated at the level of this channel to control nucleocytoplasmic trafficking. For proteins lacking active translocation signals the NPC acts as a molecular sieve limiting passage across the nuclear envelope (NE) to proteins with a MW below ~40 kD. Here, we investigate how this permeability barrier is altered in paradigms of cell death and cell survival, i.e., apoptosis induction via staurosporine, and enhanced viability via overexpression of Bcl-2. We monitor dynamic changes of the NPC’s size-exclusion limit for passive diffusion by confocal time-lapse microscopy of cells undergoing apoptosis, and use different diffusion markers to determine how Bcl-2 expression affects steady-state NE permeability. We show that staurosporine triggers an immediate and gradual leakiness of the NE preceding the appearance of apoptotic hallmarks. Bcl-2 expression leads to a constitutive increase in NE permeability, and its localization at the NE is sufficient for the effect, evincing a functional role for Bcl-2 at the nuclear membrane. In both settings, NPC leakiness correlates with reduced Ca2+ in internal stores, as demonstrated by fluorometric measurements of ER/NE Ca2+ levels. By comparing two cellular models with opposite outcome these data pinpoint ER/NE Ca2+ as a general and physiologically relevant regulator of the permeability barrier function of the NPC.
Bmc Medical Informatics and Decision Making Development and Evaluation of an Open Source Software Tool for Deidentification of Pathology Reports

Background: Electronic medical records, including pathology reports, are often used for research purposes. Currently, there are few programs freely available to remove identifiers while leaving the remainder of the pathology report text intact. Our goal was to produce an open source, Health Insurance Portability and Accountability Act (HIPAA) compliant, deidentification tool tailored for pathology reports. We designed a three-step process for removing potential identifiers. The first step is to look for identifiers known to be associated with the patient, such as name, medical record number, pathology accession number, etc. Next, a series of pattern matches look for predictable patterns likely to represent identifying data; such as dates, accession numbers and addresses as well as patient, institution and physician names. Finally, individual words are compared with a database of proper names and geographic locations. Pathology reports from three institutions were used to design and test the algorithms. The software was improved iteratively on training sets until it exhibited good performance. 1800 new pathology reports were then processed. Each report was reviewed manually before and after deidentification to catalog all identifiers and note those that were not removed.
Knowledge Extraction from Prostate Cancer Data

Although cancer research has generally been clinical and/or biological in nature, in recent years, data driven analytic research has become a common complement. In medical domains where data and analytics driven research is successfully applied, new and novel research directions are identified to further advance the clinical and biological studies. Specifically, it is the combination of the serious effects of cancer, the promising results of prior analytical research in related fields, the potential benefits of the expected research outcomes and the desire to further understand the nature of cancer that provided the motivation for this research effort. Therefore, the main objective of this research has been to take advantage of the available data mining tools and techniques to develop accurate prediction models for prostate cancer survivability, and to explain the prioritized importance of the prognostic factors.
Mutational analysis of genes coding for cell surface proteins in colorectal cancer cell lines reveal novel altered pathways, druggable mutations and mutated epitopes for targeted therapy

We carried out a mutational analysis of 3,594 genes coding for cell surface proteins (Surfaceome) in 23 colorectal cancer cell lines, searching for new altered pathways, druggable mutations and mutated epitopes for targeted therapy in colorectal cancer. A total of 3,944 somatic non-synonymous substitutions and 595 InDels, occurring in 2,061 (57%) Surfaceome genes were catalogued. We identified 48 genes not previously described as mutated in colorectal tumors in the TCGA database, including genes that are mutated and expressed in >10% of the cell lines (SEMA4C, FGFRL1, PKD1, FAM38A, WDR81, TMEM136, SLC36A1, SLC26A6, IGFLR1). Analysis of these genes uncovered important roles for FGF and SEMA4 signaling in colorectal cancer with possible therapeutic implications. We also found that cell lines express on average 11 druggable mutations, including frequent mutations (>20%) in the receptor tyrosine kinases AXL and EPHA2, which have not been previously considered as potential targets for colorectal cancer. Finally, we identified 82 cell surface mutated epitopes, however expression of only 30% of these epitopes was detected in our cell lines. Notwithstanding, 92% of these epitopes were expressed in cell lines with the mutator phenotype, opening new venues for the use of “general” immune checkpoint drugs in this subset of patients.
Ensemble Deep Learning for Skeleton-Based Action Recognition Using Temporal Sliding LSTM Networks

This paper addresses the problems of feature representation of skeleton joints and the modeling of temporal dynamics to recognize human actions. Traditional methods generally use relative coordinate systems dependent on some joints, and model only the long-term dependency, while excluding short-term and medium term dependencies. Instead of taking raw skeletons as the input, we transform the skeletons into another coordinate system to obtain the robustness to scale, rotation and translation, and then extract salient motion features from them. Considering that Long Shortterm Memory (LSTM) networks with various time-step sizes can model various attributes well, we propose novel ensemble Temporal Sliding LSTM (TS-LSTM) networks for skeleton-based action recognition. The proposed network is composed of multiple parts containing short-term, mediumterm and long-term TS-LSTM networks, respectively. In our network, we utilize an average ensemble among multiple parts as a final feature to capture various temporal dependencies. We evaluate the proposed networks and the additional other architectures to verify the effectiveness of the proposed networks, and also compare them with several other methods on five challenging datasets. The experimental results demonstrate that our network models achieve the state-of-the-art performance through various temporal features. Additionally, we analyze a relation between the recognized actions and the multi-term TS-LSTM features by visualizing the softmax features of multiple parts.
Human embryonic stem cell-derived neural precursor transplants in collagen scaffolds promote recovery in injured rat spinal cord.

BACKGROUND AIMS Several studies have reported functional improvement after transplantation of in vivo-derived neural progenitor cells (NPC) into injured spinal cord. However, the potential of human embryonic stem cell-derived NPC (hESC-NPC) as a tool for cell replacement of spinal cord injury (SCI) should be considered. METHODS We report on the generation of NPC as neural-like tubes in adherent and feeder-free hESC using a defined media supplemented with growth factors, and their transplantation in collagen scaffolds in adult rats subjected to midline lateral hemisection SCI. RESULTS hESC-NPC were highly expressed molecular features of NPC such as Nestin, Sox1 and Pax6. Furthermore, these cells exhibited the multipotential characteristic of differentiating into neurons and glials in vitro. Implantation of xenografted hESC-NPC into the spinal cord with collagen scaffold improved the recovery of hindlimb locomotor function and sensory responses in an adult rat model of SCI. Analysis of transplanted cells showed migration toward the spinal cord and both neural and glial differentiation in vivo. CONCLUSIONS These findings show that transplantation of hESC-NPC in collagen scaffolds into an injured spinal cord may provide a new approach to SCI.
EEG Neurofeedback: A Brief Overview and an Example of Peak Alpha Frequency Training for Cognitive Enhancement in the Elderly

Neurofeedback (NF) is an electroencephalographic (EEG) biofeedback technique for training individuals to alter their brain activity via operant conditioning. Research has shown that NF helps reduce symptoms of several neurological and psychiatric disorders, with ongoing research currently investigating applications to other disorders and to the enhancement of non-disordered cognition. The present article briefly reviews the fundamentals and current status of NF therapy and research and illustrates the basic approach with an interim report on a pilot study aimed at developing a new NF protocol for improving cognitive function in the elderly. EEG peak alpha frequency (PAF) has been shown to correlate positively with cognitive performance and to correlate negatively with age after childhood. The present pilot study used a double-blind controlled design to investigate whether training older individuals to increase PAF would result in improved cognitive performance. The results suggested that PAF NF improved cognitive processing speed and executive function, but that it had no clear effect on memory. In sum, the results suggest that the PAF NF protocol is a promising technique for improving selected cognitive functions.
Internet recruitment: Examining the roles of information, attitudes, and perceived fit on applicant attraction

KROUSTALIS, CHRISTINA MARIE. Internet Recruitment: Examining the Roles of Information, Attitudes, and Perceived Fit on Applicant Attraction. (Under the direction of Dr. Adam W. Meade). This study examined how organizational attitudes, which are influenced by attitudes toward Internet recruitment websites, mediate the relationship between organizational attraction and recruitment website content (amounts of job and organization information) and website design (website usability and website aesthetics). The moderating effects of personorganization (P-O) and person-job (P-J) fit were also examined. Participants were Introductory Psychology students who viewed Fortune 500 company websites and responded to questions about the content and design of these websites and their resulting attitudes, fit perceptions, and organizational attraction. Results indicated amounts of job information, organization information, website usability, and website aesthetics were positively correlated with favorable job seeker attitudes toward the recruitment website. Additionally, the amount of job information on a recruitment website interacted with website usability, such that when less job information was presented, website usability played a greater role in positively predicting organizational attitudes. Organizational attitudes were found to mediate the relationship between website content and website design on attraction to the organization. Lastly, P-J fit was found to moderate the mediation of organizational attitudes in the job information-attraction link, such that the amount of job information led to more favorable attitudes only when perceived P-J fit was high. Contrary to study hypotheses, the same moderating effect was not found for P-O fit in the organization information-organizational attitudes-attraction mediation model. Explanations of many of the significant results are explored through Spence’s (1973; 1974) signaling theory. Recommendations for the development of Internet recruitment websites are also provided. Internet Recruitment: Examining the Roles of Information, Attitudes, and Perceived Fit on Applicant Attraction by Christina Marie Kroustalis A dissertation submitted to the Graduate Faculty of North Carolina State University in partial fulfillment of the requirements for the Degree of Doctor of Philosophy Psychology Raleigh, North Carolina 2009 APPROVED BY: _____________________________ _____________________________ Dr. Adam W. Meade Dr. S. Bartholomew Craig Committee Chair _____________________________ ______________________________ Dr. Lori Foster Thompson Dr. Samuel B. Pond, III
Developing health website quality assessment guidelines for the voluntary sector: outcomes from the Judge Project.

BACKGROUND This paper describes the Judge project, the aim of which was to explore the need for health website quality assessment guidelines for the voluntary sector. Such guidelines would enable health consumers to assess the quality of health sites and assist support groups to produce their own good quality sites. The project was a partnership between the Information Management Research Institute, School of Informatics, Northumbria University and Contact a Family. It was supported by the Health Foundation. METHODS The views of health consumers and support group members and workers were obtained by focus groups (35 attendees) and questionnaires (55 responses). They were asked questions about quality issues and concerns about Internet health information and any help they needed with judging the quality of health websites. RESULTS The results supported the need for guidelines. The guidelines were written to reflect the requirements of health consumers and support groups articulated from the focus group and questionnaire data. They were then disseminated via a website. CONCLUSIONS There is a need to improve communication and information exchange between health consumers and professionals and official organizations; publicise support groups to patients and carers; set up local Webs of Trust, linking together voluntary and statutory organizations within a locality. Professionals and official organizations in the public sector should make information provision to patients and health consumers a priority. Information provision should be embedded in the clinical setting via guidelines, protocols and administrative structures. Professionals should be trained in the role of information and how to provide it in appropriate ways. Support groups should use the Judge guidelines to assist them in producing good quality websites. Support groups should promote the Judge guidelines to health consumers, to help them make their own quality judgement about health-information websites.
Emotional Strategies of Police and Their Varying Consequences for Burnout

It has been widely noted that policing is a stressful occupation, leading to a host of adverse outcomes. Many have posited that, in part, this can be explained by the emotional demands imposed on officers as a consequence of their unique role, organization, and culture. Consistent with this premise, a number of studies have found support for the notion that emotive dissonance is particularly likely to contribute to burnout. However, no studies have previously assessed how the complex emotional demands and strategies exercised within policing produce benefits and consequences for officers. Specifically, how do requirements to express coercion or apologize influence officer burnout? How do requirements to express or suppress positive or negative emotion influence burnout? And, do these effects vary depending upon whether greater surface or deep acting is required? The present study suggests that while some aspects of emotive dissonance may be negatively consequential, other emotional demands and strategies used by officers may have advantages. Specifically, while coercion in particular seems to increase depersonalization, both surface acting and attempts to deeply experience required positive emotions actually serve to decrease burnout among officers. The implications of these findings for theory, research, and the prevention of burnout among police are discussed.