Miracle-dz/UniFAR-FTUs huggingface dataset:
Management of Inflammatory Bowel Disease in the Elderly Patient: Challenges and Opportunities

Abstract: The population of older patients with inflammatory bowel disease (IBD) continues to grow, partly reflecting the aging global population in general. The debilitating effects of IBD compound age-related decrements in health and functional capacity, and make the medical management of older patients with Crohn's disease and ulcerative colitis distinctly challenging to clinicians. Here, we review the recent literature describing the pharmacologic management of IBD in this population, with focus on the safety, tolerability, and efficacy of common treatment options, such as steroids, immunomodulators, tumor necrosis factor–&agr; antagonists, and integrin antagonists; surgical interventions in older patients are also discussed. Few studies have systematically and prospectively evaluated the clinical challenges in the medical management of IBD in this patient population, leaving a limited evidence base to which clinicians can turn to for guidance. Treatment patterns may thus be suboptimal. For example, prolonged steroid use in the elderly was found to be common, causing significant morbidity from side effects in a particularly vulnerable population. Finally, within the context of a limited evidence base, we discuss common treatment scenarios to define the parameters within which physicians can individualize care for older patients with IBD. Overall, older patients with IBD are at higher risk of adverse events and less treatment responsiveness compared with younger patients, underscoring the need for future studies to fully characterize appropriate treatment courses for this population.
Labor Analgesia as a Predictor for Reduced Postpartum Depression Scores: A Retrospective Observational Study

BACKGROUND: Using labor, epidural analgesia has been linked to a reduced risk of postpartum depression, but the role of labor pain relief in this association remains unclear. The goal of this study was to test the hypothesis that effective epidural analgesia during labor is associated with reduced postpartum depression symptomatology. METHODS: A single, institutional, retrospective, observational cohort design was chosen. The primary outcome was Edinburgh postnatal depression scale (EPDS) score, measured at the 6-week postpartum visit. Subjects included in the final analysis had (1) received labor epidural analgesia; (2) pain assessed during labor both before and during initiation of labor epidural analgesia by 0–10 numeric rating scores; and (3) depression risk assessed by the EPDS and documented at their 6-week postpartum visit. Simple and multiple linear regression was used to identify the best model for assessing the association between pain improvement, defined as percent improvement in pain (PIP), and depression, after adjusting for a history of anxiety or depression, other psychiatric history, abuse, trauma, mode of delivery, and other maternal or fetal comorbid diseases. RESULTS: Two hundred one patients were included in the final analysis. Women with higher improvements in pain were associated with lower EPDS scores (r = 0.025; P = .002). Variables known to be associated with depression (body mass index, anxiety and/or depression, third- and fourth-degree perineal lacerations, and anemia) were significantly correlated with EPDS score and included in the final model. After we adjusted for these covariates, PIP remained a significant predictor of EPDS score (r = 0.49; P = .008), accounting for 6.6% of the variability in postpartum depression scores. The full model including pain, body mass index, anxiety and/or depression, perineal lacerations, and anemia explained 24% of the variability in postpartum depression scores. CONCLUSIONS: Although the extent of labor pain relief by epidural analgesia predicts lower postpartum depression scores, the relative contribution of PIP to risk for postpartum depression symptoms may be less than other established risk factors for depression. These data support that the clinical significance of labor analgesia in the development of postpartum depression needs to be more clearly defined.
Physiological and Proteomic Analysis of the Rice Mutant cpm2 Suggests a Negative Regulatory Role of Jasmonic Acid in Drought Tolerance

It is widely known that numerous adaptive responses of drought-stressed plants are stimulated by chemical messengers known as phytohormones. Jasmonic acid (JA) is one such phytohormone. But there are very few reports revealing its direct implication in drought related responses or its cross-talk with other phytohormones. In this study, we compared the morpho-physiological traits and the root proteome of a wild type (WT) rice plant with its JA biosynthesis mutant coleoptile photomorphogenesis 2 (cpm2), disrupted in the allene oxide cyclase (AOC) gene, for insights into the role of JA under drought. The mutant had higher stomatal conductance, higher water use efficiency and higher shoot ABA levels under severe drought as compared to the WT. Notably, roots of cpm2 were better developed compared to the WT under both, control and drought stress conditions. Root proteome was analyzed using the Tandem Mass Tag strategy to better understand this difference at the molecular level. Expectedly, AOC was unique but notably highly abundant under drought in the WT. Identification of other differentially abundant proteins (DAPs) suggested increased energy metabolism (i.e., increased mobilization of resources) and reactive oxygen species scavenging in cpm2 under drought. Additionally, various proteins involved in secondary metabolism, cell growth and cell wall synthesis were also more abundant in cpm2 roots. Proteome-guided transcript, metabolite, and histological analyses provided further insights into the favorable adaptations and responses, most likely orchestrated by the lack of JA, in the cpm2 roots. Our results in cpm2 are discussed in the light of JA crosstalk to other phytohormones. These results together pave the path for understanding the precise role of JA during drought stress in rice.
Electrical Potential of Leaping Eels

When approached by a large, partially submerged conductor, electric eels (Electrophorus electricus) will often defend themselves by leaping from the water to directly shock the threat. Presumably, the conductor is interpreted as an approaching terrestrial or semiaquatic animal. In the course of this defensive behavior, eels first make direct contact with their lower jaw and then rapidly emerge from the water, ascending the conductor while discharging high-voltage volleys. In this study, the equivalent circuit that develops during this behavior was proposed and investigated. First, the electromotive force and internal resistance of four electric eels were determined. These values were then used to estimate the resistance of the water volume between the eel and the conductor by making direct measurements of current with the eel and water in the circuit. The resistance of the return path from the eel's lower jaw to the main body of water was then determined, based on voltage recordings, for each electric eel at the height of the defensive leap. Finally, the addition of a hypothetical target for the leaping defense was considered as part of the circuit. The results suggest the defensive behavior efficiently directs electrical current through the threat, producing an aversive and deterring experience by activating afferents in potential predators.
Assessment of Emotion Processing Skills in Acquired Brain Injury Using an Ability-Based Test of Emotional Intelligence

Social and emotional problems are commonly reported after moderate to severe acquired brain injury (ABI) and pose a significant barrier to rehabilitation. However, progress in assessment of emotional skills has been limited by a lack of validated measurement approaches. This study represents the first formal psychometric evaluation of the use of the Mayer-Salovey-Caruso Emotional Intelligence Test (MSCEIT) V2.0 as a tool for assessing skills in perceiving, using, understanding and managing emotions following ABI. The sample consisted of 82 participants aged 18–80 years in the postacute phase of recovery (2 months–7 years) after moderate to severe ABI. Participants completed the MSCEIT V2.0 and measures of cognition and mood. Sociodemographic and clinical variables were collated from participant interview and medical files. Results revealed deficits across all MSCEIT subscales (approximately 1 SD below the normative mean). Internal consistency was adequate at overall, area, and branch levels, and MSCEIT scores correlated in expected ways with key demographic, clinical, cognitive, and mood variables. MSCEIT performance was related to injury severity and clinician-rated functioning after ABI. Confirmatory factor analysis favored a 3-factor model of EI due to statistical redundancy of the Using Emotions branch. Overall, these findings suggest that the MSCEIT V2.0 is sensitive to emotion processing deficits after moderate to severe ABI, and can yield valid and reliable scores in an ABI sample. In terms of theoretical contributions, our findings support a domain-based, 3-factor approach for characterizing emotion-related abilities in brain-injured individuals.
The Effect of Mass Ratio of Ferrocene to Camphor as Carbon Source and Reaction Time on the Growth of Carbon Nanotubes

This research aims to identify the best reaction time and mass ratio of camphor to ferrocene as carbon source in the growth of carbon nanotube (CNT). Ferrocene is used as carbon source and catalyst with stainless steel (SS)-316 type gauze as substrate.Camphor as alternative carbon source is intended to improve the CNT synthesis results. This research has shown that benzene, toluene, and xylene dominate camphor decomposition, so the addition will produce good quality CNT and increase the yield. The variation of mass ratio of camphor to ferrocene was 3:1, 2:1, 1:2, 1:3 and the variation of reaction time was 10,20,30,40, and 60 min. The synthesis results of the CNT were characterized using FESEM-EDS while the ferrocene and camphor decomposition gas was analyzed by GC-FID. The best quality of CNT was obtained at 1:2 mass ratio with yield 37%, carbon percentage of 76.98% and diameter of 77-151 nm. Increasing the reaction time from 10 to 20 minutes will increase the yield and quality of CNTs. The yield and quality of the CNT decreased after a reaction time of 30 minutes due to the deactivation of the catalyst and the closure of the active sites by nucleation and carbon growth.
LiFS: low human-effort, device-free localization with fine-grained subcarrier information

Device-free localization of people and objects indoors not equipped with radios is playing a critical role in many emerging applications. This paper presents an accurate model-based device-free localization system LiFS, implemented on cheap commercial off-the-shelf (COTS) Wi-Fi devices. Unlike previous COTS device-based work, LiFS is able to localize a target accurately without offline training. The basic idea is simple: channel state information (CSI) is sensitive to a target's location and by modelling the CSI measurements of multiple wireless links as a set of power fading based equations, the target location can be determined. However, due to rich multipath propagation indoors, the received signal strength (RSS) or even the fine-grained CSI can not be easily modelled. We observe that even in a rich multipath environment, not all subcarriers are affected equally by multipath reflections. Our pre-processing scheme tries to identify the subcarriers not affected by multipath. Thus, CSIs on the "clean" subcarriers can be utilized for accurate localization. We design, implement and evaluate LiFS with extensive experiments in three different environments. Without knowing the majority transceivers' locations, LiFS achieves a median accuracy of 0.5 m and 1.1 m in line-of-sight (LoS) and non-line-of-sight (NLoS) scenarios respectively, outperforming the state-of-the-art systems. Besides single target localization, LiFS is able to differentiate two sparsely-located targets and localize each of them at a high accuracy.
Constipation in Parkinson′s disease

Many people with PD have constipation. Usually it can be corrected with time, patience and dietary changes. Constipation is not failure to have a daily bowel movement. It is normal for some people to have a bowel movement every 3-4 days. The key is to know what is normal for you. Constipation is bowel movements that become more infrequent and are dry and difficult to pass. The key to relief is patience and consistency. Constipation takes time to develop as it takes time to restore normal bowel function. Bowel training usually takes 2 to 3 months. Often you will see no change for the first week or two. Do not be discouraged; this is normal. It is tempting to try to control bowel function with enemas or laxatives. However, these can damage the lining and function of the bowel. You should avoid them if at all possible. Some medicines, both prescription and non-prescription, cause constipation as a side effect. Have your health care provider evaluate all of your drugs.
The Evolution of gene regulation research in Lactococcus lactis

Lactococcus lactis is a major microbe. This lactic acid bacterium (LAB) is used worldwide in the production of safe, healthy, tasteful and nutritious milk fermentation products. Its huge industrial importance has led to an explosion of research on the organism, particularly since the early 1970s. The upsurge in the research on L. lactis coincided not accidentally with the advent of recombinant DNA technology in these years. The development of methods to take out and re-introduce DNA in L. lactis, to clone genes and to mutate the chromosome in a targeted way, to control (over)expression of proteins and, ultimately, the availability of the nucleotide sequence of its genome and the use of that information in transcriptomics and proteomics research have enabled to peek deep into the functioning of the organism. Among many other things, this has provided an unprecedented view of the major gene regulatory pathways involved in nitrogen and carbon metabolism and their overlap, and has led to the blossoming of the field of L. lactis systems biology. All of these advances have made L. lactis the paradigm of the LAB. This review will deal with the exciting path along which the research on the genetics of and gene regulation in L. lactis has trodden.
Characteristics of Patients Referred to a Pediatric Infectious Diseases Clinic With Unexplained Fever.

BACKGROUND Older case series established diagnostic considerations for children meeting a priori definitions of fever of unknown origin (FUO). No recent study has examined the final diagnoses of children referred for unexplained fever. METHODS This study was conducted with a retrospective chart review of patients referred to a pediatric infectious diseases clinic from 2008 to 2012 for unexplained fever. RESULTS Sixty-nine of 221 patients were referred for "prolonged" unexplained fever. Ten of these were not actually having fever, and 11 had diagnoses that were readily apparent at the initial visit. The remaining 48 were classified as having FUO. The median duration of reported fever for these patients was 30 days; 15 had a diagnosis made, 5 of which were serious. None of the serious FUO diagnoses were infections. Of 152 patients with "recurrent" unexplained fever, 92 had an "intermittent" fever pattern, and most of these had sequential, self-limited viral illnesses or no definitive diagnosis made. Twenty of the 60 patients with a "periodic" fever pattern were diagnosed with periodic fever, aphthous stomatitis, pharyngitis, and adenitis syndrome. Overall, 166 patients either were not having fever, had self-limited illnesses, or ultimately had no cause of fever discovered. Only 12 had a serious illness, 2 of which were infections (malaria and typhoid fever). CONCLUSIONS Most children referred with unexplained fever had either self-limited illnesses or no specific diagnosis established. Serious diagnoses were unusual, suggesting that these diagnoses rarely present with unexplained fever alone, or that, when they do, the diagnoses are made by primary care providers or other subspecialists.
Stability of organic solar cells with PCDTBT donor polymer: An interlaboratory study

This work is part of the interlaboratory collaboration to study the stability of organic solar cells containing PCDTBT polymer as a donor material. The varieties of the OPV devices with different device architectures, electrode materials, encapsulation, and device dimensions were prepared by seven research laboratories. Sets of identical devices were aged according to four different protocols: shelf lifetime, laboratory weathering under simulated illumination at ambient temperature, laboratory weathering under simulated illumination, and elevated temperature (65 °C) and daylight outdoor weathering under sunlight. The results generated in this study allow us to outline several general conclusions related to PCDTBT-based bulk heterojunction (BHJ) solar cells. The results herein reported can be considered as practical guidance for the realization of stabilization approaches in BHJ solar cells containing PCDTBT.
Emotional Intelligence and Physical Activity.

OBJECTIVE This report summarizes the first study (to the best of our knowledge) of the association between emotional intelligence (EI) and physical activity (PA) levels in a sample of generally healthy adults. METHODS An online snowball sample of 110 generally healthy adults took part in this study and filled out measures of EI, PA, and background variables. RESULTS Analysis of structural equating modeling supported a path of positive association between EI and PA ranging from . 20 to . 28, controlling for background variables associated with PA. Of these, only education showed significant associations with PA. CONCLUSIONS EI may play a role in individuals' PA patterns. Potential underlying mechanisms and directions for future research are suggested.
Surgical Efficiency of Anterior Cruciate Ligament Reconstruction in Outpatient Surgical Center Versus Hospital Operating Room.

Anterior cruciate ligament (ACL) reconstructions are complex orthopedic procedures in which a proficient team is of vital importance. Outpatient surgical centers (OSCs) often provide orthopedic-specific teams; however, hospital operating rooms (ORs) commonly rotate staff. The purpose of this study was to compare the efficiency of pediatric ACL reconstructions between a surgical center and a hospital OR owned and directed by a single institution. Cases examined involved pediatric patients, aged 12 to 18 years (mean age, 15.9±1.5 years), who underwent ACL reconstructions by a single orthopedic surgeon from 2009 to 2014. Procedural efficiency was defined as shorter total OR time, less total staff, and fewer support staff changes. Total OR time was also broken into 3 distinct time periods: in-room to incision time, total procedure time, and stop time to out-of-room time. A total of 49 ACL reconstructions were performed in healthy athletes, with 28 surgeries at the OSC (mean age, 15.7±1.3 years) and 21 surgeries in the hospital OR (mean age, 16.1±1.8 years). Overall efficiency was higher at the OSC, with total OR time improved by 30 minutes on average (P=.0001) with less total staff (P=.0002). Surgical technician and nursing changes occurred 6 and 2.5 times more often in the hospital OR, respectively. Procedural efficiency was greater at the OSC. The provision of consistent and experienced orthopedicspecific teams allows for improvement in OR efficiency, cost, and value. [Orthopedics. 2017; 40(5):297-302. ].
Using field data to quantify chemical impacts on wildlife population viability.

Environmental pollution is an important driver of biodiversity loss. Yet, to date, the effects of chemical exposure on wildlife populations have been quantified for only a few species, mainly due to a lack of appropriate laboratory data to quantify chemical impacts on vital rates. In this study, we developed a method to quantify the effects of toxicant exposure on wildlife population persistence based on field monitoring data. We established field-based vital-rate-response functions for toxicants, using quantile regression to correct for the influences of confounding factors on the vital rates observed, and combined the response curves with population viability modelling. We then applied the method to quantify the impact of DDE on three bird species: the White-tailed Eagle, Bald Eagle, and Osprey. Population viability was expressed via five population extinction vulnerability metrics: population growth rate (r1 ), critical patch size (CPS), minimum viable population size (MVP), probability of population extirpation (PE), and median time to population extirpation (MTE). We found that past DDE exposure concentrations increased population extirpation vulnerabilities of all three bird species. For example, at DDE concentrations of 25 mg/kg wet mass of egg (the maximum historic exposure concentration reported in literature for the Osprey), r1 became small (White-tailed Eagle and Osprey) or close to zero (Bald Eagle), the CPS increased up to almost the size of Connecticut (White-tailed Eagle and Osprey) or West Virginia (Bald Eagle), the MVP increased up to approximately 90 (White-tailed Eagle and Osprey) or 180 breeding pairs (Bald Eagle), the PE increased up to almost certain extirpation (Bald Eagle) or only slightly elevated levels (White-tailed Eagle and Osprey) and the MTE became within decades (Bald Eagle) or remained longer than a millennium (White-tailed Eagle and Osprey). Our study provides a method to derive species-specific field-based response curves of toxicant exposure, which can be used to assess population extinction vulnerabilities and obtain critical levels of toxicant exposure based on maximum permissible effect levels. This may help conservation managers to better design appropriate habitat restoration and population recovery measures, such as reducing toxicant levels, increasing the area of suitable habitat or reintroducing individuals.