Miracle-dz/UniFAR-FTUs huggingface dataset:
HUBUNGAN RESILIENSI DIRI TERHADAP TINGKAT STRES PADA DOKTER MUDA FAKULTAS KEDOKTERAN UNIVERSITAS RIAU

ABSTRACT Resilience is the ability of individuals to adjust and adapt to change, the demands and disappointments that arise in life. Resilience can affect individuals in coping with stress, by Therefore, the individual must have resilience. The level of stress each indvidu influenced by an individual's ability to perform self-adjustment to the changes that occur. Good resilience can help a person in the face of stress. The purpose of this study was to determine the relationship between resilience ourselves on the level of stress on clerkship Riau University School of Medicine. Cross sectional analytic correlative design to 83 clerkship who selected by total sampling. Collecting data using questionnaire resilience based Connor- Davidson Resilience Scale (CD-RISC) and the Medical Student stressor Quisionaaire (MMSQ) using online questionnaire (goole docs). Data analyzed bivariat by Spearman correlation test and p value = 0.552, r = -0.066, meaning that there is no meaningful relationship with a weak correlation between the resilience of the level of stress on clerkship Riau University School of Medicine. Keywords: resiliensi, stress level, clinical clerkship
Purification and characterization of a Bacteroides loeschei adhesin that interacts with procaryotic and eucaryotic cells

The adhesin of Bacteroides loeschei PK1295 that mediates coaggregation with Streptococcus sanguis 34 and hemagglutination of erythrocytes was purified to electrophoretic homogeneity. The lectinlike protein has an estimated native Mr of 450,000 and consists of six subunits of identical molecular weight (Mr 75,000). The purified adhesin appears to be a basic protein with a pI between 7.4 and 8.0. Amino acid and N-terminal sequence analyses were carried out with the purified protein. These indicated that the protein contains a large number of Asx and Glx residues as well as basic amino acid residues. The binding site of the pure adhesin retained its native configuration during purification. When preincubated with streptococcal partner cells at pH 4.6, the adhesin prevented B. loeschei cells from coaggregating with the streptococci. An adhesin preparation adjusted to a pH of 6.8 rapidly agglutinated both streptococci and neuraminidase-treated erythrocytes. Galactosides inhibited the agglutination reactions.
Molecular cloning and expression analysis of the turkey vasoactive intestinal peptide receptor.

Vasoactive intestinal peptide (VIP) is a prolactin (PRL)-releasing factor whose activity in avian species is believed to be mediated by a specific VIP receptor (VIP-R). Circulating PRL levels are closely related to hypothalamic VIP immunoreactivity, hypothalamic VIP mRNA content, and hypophysial-portal blood VIP concentrations in turkeys. In the present study, a turkey VIP-R (tVIP-R) cDNA was cloned and its mRNA abundance was quantified in various tissues during different reproductive stages. The 2347-bp tVIP-R cDNA encoded a 457 amino acid protein, with a predicted Mr of 52 kDa. The full-length cDNA shares approximately 55% similarity with the mammalian VIP receptor-1. Northern blot analysis revealed that a major 2.7-kb transcript was expressed in laying hen pituitaries. Furthermore, two minor tVIP-R transcripts of 3.7 and 3.4 kb were observed. Semiquantitative reverse transcription polymerase chain reaction (RT-PCR) was performed using RNA from various turkey brain and peripheral tissues throughout the reproductive cycle. The steady-state levels of pituitary tVIP-R mRNA changed during the reproductive cycle, whereas mRNA expression in other tissues was not affected. The steady-state levels of tVIP-R mRNA were only affected in the pituitary, whereas mRNA expression in any of the other tissues examined following the immunization of turkeys against VIP were not affected.
On the design of LAS spreading codes

A family of large area synchronised (LAS) codes is studied, which exhibits a so-called interference free window (IFW), where both the intersymbol interference (ISI) and the multiple user interference (MAI) are suppressed, provided that the relative time offset of the codes is within the IFW. Hence, LAS codes have the potential of increasing the capacity of CDMA networks. However, a specific drawback of this family of sequences is their relatively low duty ratio. A modified algorithm is proposed for determining the constituent LA code's pulse positions for the sake of improving the duty ratio of the corresponding LAS codes. It is shown that the modified LAS codes exhibit an 18.6% higher duty ratio, than that of the original LAS codes, when considering a minimum LA code pulse interval of 38. The LAS code design examples provided revealed that the system employing the proposed approach improved the data throughput by 40% for the scenario, when the required IFW is /spl plusmn/4-chips and the minimum pulse interval is 19. The availability of the LAS codes is also investigated in conjunction with for the various LS and LA code lengths, employing an extended LS code construction scheme for polyphase complementary sequences and orthogonal LA pulse codes. It is shown that these modified spreading code construction schemes can be combined for generating a family of LAS codes in order to meet various design requirements.
Determinants of hypomagnesemia in patients with type 2 diabetes mellitus.

BACKGROUND Hypomagnesemia (plasma magnesium (Mg2+) concentration <0.7 mmol/L) has been described in patients with type 2 diabetes. Polypharmacy is inevitable when treating a complex disease such as type 2 diabetes and could explain disturbances in the plasma Mg2+ concentration. In this study, we aimed to establish the extent of hypomagnesemia in a cohort of type 2 diabetes patients and to identify the determinants of plasma Mg2+ levels. METHODS Patient data and samples of 395 type 2 diabetes patients were investigated. Plasma Mg2+ concentrations were measured using a spectrophotometric assay. Using Pearson correlation analyses, variables were correlated to plasma Mg2+ levels. After excluding confounding variables, all parameters correlating (P < 0.1) with plasma Mg2+ were included in a stepwise backward regression model. RESULTS The mean plasma Mg2+ concentration in this cohort was 0.74 ± 0.10 mmol/L. In total, 121 patients (30.6%) suffered from hypomagnesemia. Both plasma triglyceride (r = -0.273, P < 0.001) and actual glucose levels (r = -0.231, P < 0.001) negatively correlated with the plasma Mg2+ concentration. Patients using metformin (n = 251, 62%), proton pump inhibitors (n = 179, 45%) or β-adrenergic receptor agonists (n = 31, 8%) displayed reduced plasma Mg2+ levels. Insulin use (n = 299, 76%) positively correlated with plasma Mg2+ levels. The model predicted (R2) 20% of all variance in the plasma Mg2+ concentration. CONCLUSIONS Hypomagnesemia is highly prevalent in type 2 diabetes patients. Plasma triglycerides and glucose levels are major determinants of the plasma Mg2+ concentration, whereas only a minor part (<10%) of hypomagnesemia can be explained by drug intake, excluding polypharmacy as a major cause for hypomagnesemia in type 2 diabetes.
Expected Performance of the LHC Synchrotron-Light Telescope (BSRT) and Abort-Gap Monitor (BSRA) *

Summary This Report presents calculations of the synchrotron light from proton and lead-ion beams in the LHC at all energies from 0.45 to 7 TeV. It computes the emission from three sources: the uniform-field region of the D3 dipole, the dipole’s edge field, and the short undulator just upstream. Light emitted at or near visible wavelengths is assessed for making optical measurements of transverse beam profiles and for monitoring the emptiness of the abort gap in the fill pattern. There is sufficient light for both applications, although both species pass through energy ranges in the ramp with small photon counts. Effects limiting image resolution are examined, including geometric optics, depth of field, and diffraction. The Report also considers recent suggestions that the undulator, intended to supplement the dipole for low energies, should not be ramped off at high energies and perhaps should not be used at all. We conclude that the undulator is essential at low energy for both species, but that it is possible to leave the undulator on at the cost of some blurring at intermediate energies.
Not Quite as Grown-Up as We Like to Think

Greater continuity in cognition between children and adults may exist than is usually appreciated. It was thought that after 3 to 4 years of age, the problem in switching on the dimensional-change card-sort task disappears. We show here, however, that if speed is used as the dependent measure, the effect of the first dimension is evident even in adults. Adults, like preschoolers, show difficulty in switching from a block of sorting by color or shape to a block of sorting by the other dimension. Notably, performance throughout the session was affected by the first dimension by which stimuli were sorted. We hypothesize that perhaps adults never fully outgrow any of the cognitive and perceptual biases of infancy and early childhood. Other examples of such biases that appear to still be present in adults are discussed. Conversely, the assumption that the optimal dependent measure for adults is the most sensitive measure for children is questioned.
Image-based rendering and tracking of faces

In this paper, we present an image-based method for the tracking and rendering of faces. We use the algorithm in an immersive video conferencing system where multiple participants are placed at a virtual table. This requires viewpoint modification of dynamic objects. Since hair and uncovered areas are difficult to model by pure 3-D geometry-based warping, we add image-based rendering techniques to the system. By interpolating novel views from a 3-D image volume, natural looking results can be achieved. The image-based component is embedded into a geometry-based approach that models temporally changing facial features. Both geometry and image cube information are jointly exploited in facial expression analysis and synthesis.
The Bereaved Child

tragedy but as something shameful and even obscene; these attitudes rub off on children. Fortunately in this country, though not in countries at war, such as Vietnam, the number of orphans has steadily decreased as medical science has progressed and standards of living improved. And bereavement and separation are now recognised as important factors in children's behaviour, although the effect of childhood grieving on later life is less widely accepted. Dr. Felix Brown, the consultant psychiatrist who has done considerable work in this field, told me: 'I have been particularly impressed by the large numbers of depressive patients in adult life that I have seen who were orphaned in childhood. ' In a recent study* at the Hampstead branch of the Royal Free Hospital, Dr. Brown compared 331 outpatients suffering from depression with 296 patients attending local doctors for various ailments (average age for all patients was 43), and with statistics in the 1921 census. He found that nearly twice as many had been orphaned before the age of 15 among those with depression compared with the other two groups. In another investigation* into the relationship between orphanhood and delinquency, Dr. Brown (with Dr. Phyllis Epps) found that, compared with the general population, a considerably higher proportion ? f prisoners? even higher among women than men ? had lost either a mother or father before 15 years. This does not mean that every bereaved child becomes
Alterations of erythrocyte free radical defense system, heart tissue lipid peroxidation, and lipid concentration in streptozotocin-induced diabetic rats under coenzyme Q10 supplementation.

OBJECTIVE Free radicals play an important role in genesis and development of various chronic diseases and aging. Our objective is to study the effects of coenzyme Q10 (CoQ10) supplementation on erythrocyte antioxidants, heart tissue lipid peroxidation end products and lipid concentration in different age of diabetic rats. METHODS In this study, the activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and the content of reduced glutathione (GSH) were determined in erythrocytes. The products of lipid peroxidation were determined in the heart tissues of streptozotocin-induced diabetic rats and in healthy rats at 4, 8, and 13-months of age. The above mentioned antioxidant systems of erythrocytes were also determined after supplementation of diabetic and healthy rats with CoQ10. This study was carried out in King Fahad Medical Research Center, Jeddah, Kingdom of Saudi Arabia between 2000 and 2001. RESULTS In erythrocytes of diabetic rats the activity of GSH-Px was significantly decreased (p<0.001) in all different age groups, whereas the activity of SOD was significantly increased (p<0.001). However, in erythrocyte of streptozotocin-induced diabetic rats, the concentration of GSH and high-density lipoprotein (HDL)-cholesterol were significantly lower than non-diabetic rats. Moreover, the concentration of heart tissue lipid peroxidation end products, and plasma glucose, cholesterol and triacylglycerol were significantly increased (p<0.001) in all age groups of diabetic rats. Daily supplementation with CoQ10 (10 mg/kg body weight, one month) after induction of diabetes to the rats resulted in the following changes: an increase in both erythrocyte GSH concentration and GSH-Px activity, and slightly increases in plasma HDL-cholesterol. However, SOD activity was significantly decreased (p<0.05). In addition, the levels of lipid peroxidation end products, and triacylglycerol were significantly decreased (p<0.05) in diabetic rats supplemented with CoQ10. CONCLUSION The results of the present study indicated that CoQ10 supplementation helps to prevent clinical complications during the course of the disease in diabetic rats.
Wikification for Scriptio Continua

The fact that Japanese employs scriptio continua, or a writing system without spaces, complicates the first step of an NLP pipeline. Word segmentation is widely used in Japanese language processing, and lexical knowledge is crucial for reliable identification of words in text. Although external lexical resources like Wikipedia are potentially useful, segmentation mismatch prevents them from being straightforwardly incorporated into the word segmentation task. If we intentionally violate segmentation standards with the direct incorporation, quantitative evaluation will be no longer feasible. To address this problem, we propose to define a separate task that directly links given texts to an external resource, that is, wikification in the case of Wikipedia. By doing so, we can circumvent segmentation mismatch that may not necessarily be important for downstream applications. As the first step to realize the idea, we design the task of Japanese wikification and construct wikification corpora. We annotated subsets of the Balanced Corpus of Contemporary Written Japanese plus Twitter short messages. We also implement a simple wikifier and investigate its performance on these corpora.
Myricetin protects hippocampal CA3 pyramidal neurons and improves learning and memory impairments in rats with Alzheimer's disease

There is currently no treatment for effectively slowing the progression of Alzheimer's disease, so early prevention is very important. Numerous studies have shown that flavonoids can improve memory impairment. The present study investigated the effects of myricetin, a member of the flavonoids, on intracerebroventricular streptozotocin induced neuronal loss and memory impairment in rat models of Alzheimer's disease. Myricetin at 5 or 10 mg/kg was intraperitoneally injected into rats over 21 days. Control rats were treated with 10 mL/kg saline. Behavioral test (the shuttle box test) was performed on day 22 to examine learning and memory in rats. Immediately after that, hematoxylin-eosin staining was performed to observe the morphological change in hippocampal CA3 pyramidal neurons. Myricetin greatly increased the number of hippocampal CA3 pyramidal neurons and improved learning and memory impairments in rats with Alzheimer's disease. These findings suggest that myricetin is beneficial for treatment of Alzheimer's disease.
Cell Death and Reproductive Regression in Female Schistosoma mansoni

The vitellarium is a highly proliferative organ, producing cells which are incorporated along with a fertilized ovum into the schistosome egg. Vitellarial growth fails to occur in virgin female schistosomes in single sex (female-only) infections, and involution of this tissue, which is accompanied by physical shrinkage of the entire worm, occurs when mature females sexually regress upon removal from their male partners. We have found that upon removal from their hosts into tissue culture, female parasites regress whether they are mated or not, but that cessation of egg production and a decline in expression of the vitelline gene p14 is delayed by mating. We used BrdU labeling to investigate whether there was a loss of proliferation in the vittelarium that might account for regression and found that the proliferation rate declined equally in paired and singled females once placed into culture. However, TUNEL staining and Caspase 3 activity measurements indicate that the loss of vitrellarial cellularity associated with regression is associated with profound apoptotic vitelline cell death, which is not apparent in the vitellaria of paired females immediately ex vivo, and which develops in vitro regardless of whether males are present or not. Furthermore, primordial vitellaria in virgin females have a high frequency of apoptotic cells but are characterized by a proliferation rate that is indistinguishable from that in fully developed vitellaria in mature paired females. Taken together, our data suggest that the vitelline proliferation rate is independent of pairing status. In contrast, the survival of vitelline cells, and therefore the development of the vitellarium, is highly male-dependent. Both processes are negatively affected by removal from the host regardless of whether male worms are present or not, and are unsustainable using standard tissue culture approaches.
Randomized phase III study of panitumumab with fluorouracil, leucovorin, and irinotecan (FOLFIRI) compared with FOLFIRI alone as second-line treatment in patients with metastatic colorectal cancer.

PURPOSE Panitumumab is a fully human anti-epidermal growth factor receptor (EGFR) monoclonal antibody that improves progression-free survival (PFS) in chemotherapy-refractory metastatic colorectal cancer (mCRC). This trial evaluated the efficacy and safety of panitumumab plus fluorouracil, leucovorin, and irinotecan (FOLFIRI) compared with FOLFIRI alone after failure of initial treatment for mCRC by tumor KRAS status. PATIENTS AND METHODS Patients with mCRC, one prior chemotherapy regimen for mCRC, Eastern Cooperative Oncology Group performance status 0 to 2, and available tumor tissue for biomarker testing were randomly assigned 1:1 to panitumumab 6.0 mg/kg plus FOLFIRI versus FOLFIRI every 2 weeks. The coprimary end points of PFS and overall survival (OS) were independently tested and prospectively analyzed by KRAS status. RESULTS From June 2006 to March 2008, 1,186 patients were randomly assigned 1:1 and received treatment. KRAS status was available for 91% of patients: 597 (55%) with wild-type (WT) KRAS tumors, and 486 (45%) with mutant (MT) KRAS tumors. In the WT KRAS subpopulation, when panitumumab was added to chemotherapy, a significant improvement in PFS was observed (hazard ratio [HR] = 0.73; 95% CI, 0.59 to 0.90; P = .004); median PFS was 5.9 months for panitumumab-FOLFIRI versus 3.9 months for FOLFIRI. A nonsignificant trend toward increased OS was observed; median OS was 14.5 months versus 12.5 months, respectively (HR = 0.85, 95% CI, 0.70 to 1.04; P = .12); response rate was improved to 35% versus 10% with the addition of panitumumab. In patients with MT KRAS, there was no difference in efficacy. Adverse event rates were generally comparable across arms with the exception of known toxicities associated with anti-EGFR therapy. CONCLUSION Panitumumab plus FOLFIRI significantly improved PFS and is well-tolerated as second-line treatment in patients with WT KRAS mCRC.
Prognostic value of resting end-tidal carbon dioxide in patients with heart failure.

BACKGROUND Cardiopulmonary exercise testing (CPET) variables provide valuable prognostic information in the heart failure (HF) population. The purpose of the present study is to assess the ability of resting end-tidal carbon dioxide partial pressure (PETCO2) to predict cardiac-related events in patients with HF. METHODS 121 subjects diagnosed with compensated HF underwent CPET on an outpatient basis. Mean age and ejection fraction were 49.3 years (+/-14.7) and 28.4% (+/-13.4), respectively. Resting P(ET)CO2 was determined immediately prior to the exercise test in the seated position. Peak oxygen consumption (VO2) and the minute ventilation-carbon dioxide production (VE/VCO2) slope were also acquired during CPET. RESULTS There were 41 cardiac-related hospitalizations and 9 cardiac-related deaths in the year following CPET. Mean resting P(ET)CO2, peak VO2 and VE/VCO2 slope were 34.1 mmHg (+/-4.6), 14.5 ml*kg(-1)*min(-1) (+/-5.1) and 35.9 (+/-8.7) respectively. Univariate Cox regression analysis revealed that resting P(ET)CO2 (Chi-square=28.4, p<0.001), peak VO2 (Chi-square=21.6, p<0.001) and VE/VCO2 slope (Chi-square=54.9, p<0.001) were all significant predictors of cardiac related events. Multivariate Cox regression analysis revealed resting P(ET)CO2 added to the prognostic value of VE/VCO2 slope in predicting cardiac related events (residual Chi-square=4.4, p=0.04). Peak VO2 did not add additional value and was removed (residual Chi-square=3.2, p=0.08). CONCLUSIONS These results indicate a resting ventilatory expired gas variable possesses prognostic value independently and in combination with an established prognostic marker from the CPET. Resting P(ET)CO2 may therefore be a valuable objective measure to obtain during both non-exercise and exercise evaluations in patients with HF.
The Meaning of Empowerment: The Interdisciplinary Etymology of A New Management Concept

Empowerment has become a widely used management term in the last decade or so, though, in practical terms, it shares the ambiguity of its predecessors in the HRM tradition. This paper sets out to unravel the web of meaning surrounding empowerment to show what a contested concept it is, and hence why its application in organizational settings is fraught with misunderstanding and tension. It does so by taking an approach that contributes to the examination of HRM discourse and management rhetoric. To demonstrate the ambiguity of empowerment as a concept, the paper reviews the various ways in which the term has been used across non-management disciplines (women, minority groups, education, community care, politics), culminating with a review of the use of empowerment in contemporary management theory. The paper concludes that organizations and managers have chosen to coin a phrase which is open to different, sometimes contradictory, meanings and which, when applied, evokes both subjective attitudes and objective behaviour, means different things in varying contexts, and is affected fundamentally by individual differences in perception and experience. Unless organizations offer clear operational definitions when using empowerment, instead of purely acquiescing to a vague and seductive version of the concept, they are abdicating responsibility for the unpredictable consequences that result.