Miracle-dz/UniFAR-FTUs huggingface dataset:
Illusory Correlations: A Simple Associative Algorithm Provides a Convergent Account of Seemingly Divergent Paradigms

Subjective correlations that exaggerate objectively presented contingencies are usually referred to as illusory correlations. An empirical review reveals 3 major paradigms of illusory correlations, drawing on 2 prominent but conflicting gestalt principles, congruency and distinctiveness. Congruency accounts for expectancy-based illusory correlations, whereas distinctiveness is relevant to illusions resulting from the asymmetry of positive and negative attributes and from infrequency. The congruency principle implies a processing advantage for expected stimuli, whereas distinctiveness assumes enhanced processing of unexpected events. This apparent conflict is resolved, and an integrative account is offered within a simple connectionist framework (BIAS) of correlation assessment. The basic algorithm is outlined, empirical findings are simulated, new theoretical distinctions are introduced, and analogies to related paradigms are explained.
Coronary calcium does not accurately predict near-term future coronary events in high-risk adults.

BACKGROUND Prognostic risk models have had limited success in predicting coronary events in subjects with multiple risk factors. We and others have proposed an alternative approach using radiographically detectable coronary calcium. We evaluated and compared the predictive value of these 2 approaches for determining coronary event risk in asymptomatic adults with multiple coronary risk factors. In addition, we assessed the predictive value of a risk model that included calcium score and cardiac risk-factor data. METHODS AND RESULTS We recruited 1196 asymptomatic high-coronary-risk subjects who then underwent risk-factor assessment and cardiac electron-beam CT (EBCT) scanning and were followed up for 41 months with a 99% success rate. We applied the Framingham model and our data-derived risk model to determine the 3-year likelihood of a coronary event. The mean age of our cohort was 66 years, and mean 3-year Framingham risk was 3.3+/-3.6%. Sixty-eight percent (818 subjects) had detectable coronary calcium. There were 17 coronary deaths (1.4%) and 29 nonfatal infarctions (2. 4%). The receiver operating characteristic (ROC) curve areas calculated from the Framingham model, our data-derived risk model, and the calcium score were 0.69+/-0.05, 0.68+/-0.05, and 0.64+/-0.05, respectively (P=NS). When calcium score was included as a variable in the data-derived model, the ROC area did not change significantly (0.68+/-0.05 to 0.71+/-0.04; P=NS). CONCLUSIONS Neither risk-factor assessment nor EBCT calcium is an accurate event predictor in high-risk asymptomatic adults. EBCT calcium score does not add significant incremental information to risk factors, and its use in clinical screening is not justified at this time.
Trust, Confidence and Cooperation model: a framework for understanding the relation between trust and Risk Perception

The nature of the relation between trust and Risk Perception (RP) has recently become a focus of increased interest among risk management researchers. Some argue that trust is strongly related to RP and that it therefore might prove to be a key to the development of more effective risk communication techniques. However, others claim that trust is weakly related, if at all, to RP and that it would be of little use to risk communicators and managers. A recent analysis of relevant empirical studies (Earle, Siegrist and Gutscher, 2007) supported neither the strong- nor the weak-relation argument. A wide variety of studies indicated, instead, that the relation between trust and RP is conditioned by certain critical contextual factors. Although much remains to be learned about these factors, the most important among them appear to be: (a) the judged moral importance (to individuals) of the risk management issue, and (b) the individuals' judged personal knowledge of or familiarity with the issue. These factors are elements of a general model of the relations among Trust, Confidence and Cooperation (TCC), the TCC model. In this article, we demonstrate how the TCC model can generate useful hypotheses about the relation between trust and RP in important risk management contexts characterised by different levels of moral importance and knowledge.
The Open University ’ s repository of research publications and other research outputs CAPRI and RASAL impose different modes of information processing on Ras due to contrasting temporal filtering of Ca

(2005). CAPRI and RASAL impose different modes of information processing on Ras due to contrasting temporal filtering of Ca2+. Copyright and Moral Rights for the articles on this site are retained by the individual authors and/or other copyright owners. For more information on Open Research Online's data policy on reuse of materials please consult the policies page. he versatility of Ca 2 ϩ as a second messenger lies in the complex manner in which Ca 2 ϩ signals are generated. How information contained within the Ca 2 ϩ code is interpreted underlies cell function. Recently, we identified CAPRI and RASAL as related Ca 2 ϩ-triggered Ras GTPase-activating proteins. RASAL tracks agonist-stimulated Ca 2 ϩ oscillations by repetitively associating with the plasma membrane, yet CAPRI displays a long-lasting Ca 2 ϩ-triggered translocation that is refractory to cytosolic Ca 2 ϩ oscillations. CAPRI behavior is Ca 2 ϩ-and C2 domain–dependent but sustained recruitment is pre-T dominantly Ca 2 ϩ independent, necessitating integration of Ca 2 ϩ by the C2 domains with agonist-evoked plasma membrane interaction sites for the pleckstrin homology domain. Using an assay to monitor Ras activity in real time, we correlate the spatial and temporal translocation of CAPRI with the deactivation of H-Ras. CAPRI seems to low-pass filter the Ca 2 ϩ signal, converting different intensities of stimulation into different durations of Ras activity in contrast to the preservation of Ca 2 ϩ frequency information by RASAL, suggesting sophisticated modes of Ca 2 ϩ-regulated Ras deactivation.
Interferon-gamma regulates idiopathic pneumonia syndrome, a Th17+CD4+ T-cell-mediated graft-versus-host disease.

RATIONALE Pulmonary complications of hematopoietic stem cell transplantation include infections and graft-versus-host diseases, such as idiopathic pneumonia syndrome (IPS). Conflicting data exist regarding the role of the interferon (IFN)-gamma-producing Th1 CD4(+) T-cell subset and IL-17A in IPS. OBJECTIVES To determine the role of IFN-gamma and IL-17A in the establishment of pulmonary graft-versus-host disease. METHODS A semiallogeneic murine model based on C57BL/6 x BALB/c as recipients with transplantation of BALB/c RAG2(-/-) bone marrow and transfer of different genetic knockout T cells (T-bet(-/-), IFN-gamma(-/-), IFN-gammaR(-/-)) on a BALB/c background. Lung tissue was examined for parenchymal changes and infiltrating cells by histology and fluorescence-activated cell sorter analysis. MEASUREMENTS AND MAIN RESULTS After transfer of semiallogeneic bone marrow together with donor CD4(+) T cells lacking IFN-gamma or T-bet-a T-box transcription factor controlling Th1 commitment-we found severe inflammation in the lungs, but no enhancement in other organs. In contrast, wild-type donor CD4(+) T cells mediated minimal inflammation only, and donor CD8(+) T cells were not required for IPS development. Mechanistically, the absence of IFN-gamma or IFN-gamma signaling in pulmonary parenchymal cells promoted expansion of IL-17A-producing CD4(+) T cells and local IL-17A release. In vivo depletion of IL-17A reduced disease severity. CONCLUSIONS One mechanism of IFN-gamma protection against IPS is negative regulation of the expansion of pathogenic IL-17A-producing CD4(+) T cells through interaction with the IFN-gamma receptor on the pulmonary parenchymal cell population.
Behavioral versus cognitive treatment of obsessive-compulsive disorder: an examination of outcome and mediators of change.

OBJECTIVE To examine symptom change over time, the effect of attrition on treatment outcome, and the putative mediators of cognitive therapy (CT) versus behavior therapy (BT) for obsessive-compulsive disorder (OCD) using archival data. METHOD Sixty-two adults with OCD were randomized to 20 sessions of CT (N = 30) or BT (N = 32) that consisted of 4 weeks of intensive treatment (16 hr total) and 12 weeks of maintenance sessions (4 hr). Independent evaluators assessed OCD severity using the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) at baseline and at Weeks 4, 16 (posttreatment), 26, and 52 (follow-up). Behavioral avoidance, depressive symptoms, and dysfunctional beliefs regarding responsibility were also measured at each assessment. Study hypotheses were tested using multilevel modeling. RESULTS The slope of change in Y-BOCS scores was significantly greater in BT than in CT (d = 0.69), and those receiving BT had lower Y-BOCS scores at the final assessment than those receiving CT (d = 1.17). The greater slope of change in BT versus CT did not differ for dropouts versus completers. Reduction in depressed mood mediated changes in Y-BOCS across the 2 treatments, but a reduction in sense of responsibility and a decrease in avoidance did not. Instead, Y-BOCS improvements appeared to precede a decrease in avoidance. CONCLUSIONS BT may have some therapeutic advantage over CT in the treatment of OCD, and this advantage does not appear to be due to a differential pattern of responding for treatment dropouts versus completers. Further, inconsistent with hypotheses, improvements in OCD symptoms were mediated by reductions in depressed mood instead of decreases in avoidance and responsibility. Theoretical, methodological, and clinical implications are discussed.
Inductive Logic Programming through Estimation of Distribution Algorithm

Genetic Algorithms (GAs) are known for their capacity to explore large search spaces and due to this ability, they were to some extent applied to Inductive Logic Programming (ILP) problem. Although Estimation of Distribution Algorithms (EDAs) perform better in most problems when compared to standard GAs, this kind of algorithm have not been applied to ILP. This work presents an ILP system based on EDA. Preliminary results show that the proposed system is superior when compared to a “standard” GA and it is very competitive when compared to the state of the art ILP system Aleph.
To Defer or to Stand up? How Offender Formidability Affects Third Party Moral Outrage

According to models of animal behavior, the relative formidability of conspecifics determines the utility of deferring versus aggressing in situations of conflict. Here we apply and extend these models by investigating how the formidability of exploiters shapes third party moral outrage in humans. Deciding whether to defer to or stand up against a formidable exploiter is a complicated decision as there is both much to lose (formidable individuals are able and prone to retaliate) and much to gain (formidable individuals pose a great future threat). An optimally designed outrage system should, therefore, be sensitive to these cost-benefit trade-offs. To test this argument, participants read scenarios containing exploitative acts (trivial vs. serious) and were presented with head-shot photos of the apparent exploiters (formidable vs. non-formidable). As predicted, results showed that, compared to the non-formidable exploiter, the formidable exploiter activated significantly more outrage in male participants when the exploitative act was serious. Conversely, when it was trivial, the formidable exploiter activated significantly less outrage in male participants. However, these findings were conditioned by the exploiters' perceived trustworthiness. Among female participants, the results showed that moral outrage was not modulated by exploiter formidability.
A Reanalysis of Cognitive-Functional Performance in Older Adults: Investigating the Interaction Between Normal Aging, Mild Cognitive Impairment, Mild Alzheimer's Disease Dementia, and Depression

Depressive symptoms are associated with cognitive-functional impairment in normal aging older adults (NA). However, less is known about this effect on people with mild Cognitive Impairment (MCI) and mild Alzheimer's disease dementia (AD). We investigated this relationship along with the NA-MCI-AD continuum by reanalyzing a previously published dataset. Participants (N = 274) underwent comprehensive neuropsychological assessment including measures of Executive Function, Language/Semantic Memory, Episodic Memory, Visuospatial Abilities, Activities of Daily Living (ADL), and the Geriatric Depression Scale. MANOVA, logistic regression and chi-square tests were performed to assess the association between depression and cognitive-functional performance in each group. In the NA group, depressed participants had a lower performance compared to non-depressed participants in all cognitive and functional domains. However, the same pattern was not observed in the MCI group or in AD. The results suggest a progressive loss of association between depression and worse cognitive-functional performance along the NA-MCI-AD continuum.
Inhibition of Mammalian Legumain by Michael Acceptors and AzaAsn-Halomethylketones

Abstract Legumain is a lysosomal cysteine peptidase specific for an asparagine residue in the P1-position. It has been classified as a member of clan CD peptidases due to predicted structural similarities to caspases and gingipains. So far, inhibition studies on legumain are limited by the use of endogenous inhibitors such as cystatin C. A series of Michael acceptor inhibitors based on the backbone CbzLAlaLAlaLAsn (Cbz= benzyloxycarbonyl) has been prepared and resulted in an irreversible inhibition of porcine legumain. Variation of the molecular size within the war head revealed the best inhibition for the compound containing the allyl ester (kobs/I=766 M 1s 1). To overcome cyclisation between the amide moiety of the Asn residue and the war head, several asparagine analogues have been synthesised. Integrated in halomethylketone inhibitors, azaasparagine is accepted by legumain in the P1-position. The most potent inhibitor of this series, CbzLAlaLAlaAzaAsnchloromethylketone, displays a kobs/I value of 139 000 M 1s 1. Other cysteine peptidases, such as papain and cathepsin B, are not inhibited by this compound at concentrations up to 100 M. The synthetic inhibitors described here represent useful tools for the investigation of the structural and physiological properties of this unique asparaginespecific peptidase.
Computing Affine Combinations, Distances, and Correlations for Recursive Partition Functions

Recursive partitioning is the core of several statistical methods including CART, random forest, and boosted trees. Despite the popularity of tree based methods, to date, there did not exist methods for combining multiple trees into a single tree, or methods for systematically quantifying the discrepancy between two trees. Taking advantage of the recursive structure in trees we formulated fast algorithms for computing affine combinations, distances and correlations in a vector subspace of recursive partition functions.
Ethnicity, body shape differences and female consumers' apparel fit problems

This research compared body shapes, measurements, ratios and fit problems of 234 African (109) and Caucasian (125) women. A three-dimensional (3D) full-body scanner generated virtual body images from which circumferential, width, protrusion and height measurements were extracted. Thereafter, circumferential and height ratios were computed. Drop values of key circumferential measurements were used to classify participants' bodies that were later visually confirmed and adopted. Results revealed that triangle, hourglass and rectangle were the three most predominant shapes among African and Caucasian women. There was a significant association between the three most predominant body shapes and ethnicity. There were significant differences in some body measurements and ratios, most of which were observed between African and Caucasian triangle as well as some of the other body shapes and the Caucasian hourglass used in the apparel industry. The differences especially between Caucasian hourglass and the other body shapes may be resulting in the persistent fit problems reported by some of the predominant body shapes at some of the selected body parts. This study therefore concluded that multicultural markets need to identify characteristics of all prevalent shapes within a population in order to minimize apparel fit problems.
The Relationship of Cause of Death to Attitudes Toward Funerals and Bereavement Adjustment

Four hundred and thirty-eight adults aged eighteen to eighty-eight (M age = 35) who had lost a close friend or family member within the last two years completed questionnaires to ascertain the relationship of cause of death to attitudes toward the funeral and bereavement adjustment. While deaths that were expected were associated with more adaptive bereavement adjustment, cause of death was independent of participation in prefuneral, funeral, and postfuneral rituals, as well as attitudes toward the funeral. Expected deaths of persons to whom bereaved persons felt emotionally close were linked to more adaptive bereavement adjustment, greater positive meaning attributed to the funeral, and somewhat greater postfuneral participation. Such effects were minimized when data for deceased persons to whom the bereaved felt less close were examined. When specific causes of death were examined, those losing a loved one to either murder/suicide or accident fared worse regarding bereavement adjustment, and had less funeral participation. Regarding bereavement adjustment, this was especially the case when the deaths of close family were considered, except that such persons had greater funeral participation. Neither length of time since bereavement nor age interacted with cause of death to affect funeral attitudes or bereavement adjustment. While these data partially support the hypothesis that the impact of funerals is relative to the nature of loss, they also suggest that cause of death interacts with closeness to the deceased in affecting bereavement adjustment.
Developmental Trends in False Memory Across Adolescence and Young Adulthood: A Comparison of DRM and Memory Conformity Paradigms

Summary: Little is known about the reliability of eyewitness memory among adolescents as most memory research has focused primarily on adults and young children. A number of studies recently have emerged outlining conditions where memory suggestibility increases from early childhood to adulthood. These developmental reversals are found in semantic association tasks such as the Deese–Roediger–McDermott (DRM) paradigm and have not yet been thoroughly investigated among adolescents. In the current study, we examined DRM performance among 11–21year olds (N=245). Extending the work comparing children and adults, false memory on the DRM task increased with age. False memory on the DRM task was not associated with false memory on a memory conformity task. The different memory processes involved with the tasks and the implications for legal psychology are discussed. Copyright © 2015 John Wiley & Sons, Ltd. Adolescents have been almost wholly ignored in the eyewitness testimony literature (McGuire, London, & Wright, 2011), with scores of developmental studies instead focusing on young children. Up until the 1980s, child competence statutes generally excluded the testimony of youth on the grounds that young children’s testimony is unreliable (Brainerd & Reyna, 2012; Bruck & Ceci, 1999; Goodman, 1984). Many developmental studies provided empirical support for this legal practice, showing preschoolers to be much more suggestible than grade school-aged children (e.g., Goodman & Reed, 1986; Robinson & Briggs, 1997). However, the notion that young children are incompetent witnesses is an oversimplification. Forensic developmental research has shown that young children can sometimes very accurately recount events (Peterson, 2012), while at times even adults err on eyewitness tasks (Loftus, 2005).
Spinopelvic Alignment in Patients With Osteoarthrosis of the Hip: A Radiographic Comparison to Patients with Low Back Pain

Study Design. A retrospective, age- and sex-matched radiographic study. Objectives. To investigate the spinopelvic alignment in patients with osteoarthosis of the hip (HOA) and those with low back pain (LBP) and to determine the characteristics and differences in both groups. Summary of Background Data. Hip-spine syndrome, first described by Offierski and MacNab, is quite an important pathology when treating patients with pain in their low back and lower extremities. However, despite it being a well-known entity, few papers have adequately investigated and assessed the spinopelvic alignment in patients with hip-spine syndrome. Methods. Sagittal and coronal spinopelvic alignments were investigated in 150 patients with HOA and 150 with LBP using radiographs of the whole spine in both anteroposterior and lateral views. Parameters measured in this study were lumbar lordosis (LL), sacral slope (SS), the shift of the sagittal C7 plumb line, pelvic incidence (PI), and pelvic tilt (PT) on the lateral radiographs. On the anteroposterior (AP) films, lumbar scoliosis, pelvic obliquity, leg length discrepancy, the shift of the coronal C7 plumb line, and Sharp angle were measured. These parameters were compared between the two groups. In patients with HOA, the relationships between Sharp angle and other parameters were also analyzed to clarify the possible influence of sagittal and coronal spinopelvic alignments on HOA without acetabular dysplasia. Results. LL, SS, PI, and PO were found to be less in patients with LBP compared with those with HOA, and there was no significant difference in LS between the two groups. PI was significantly greater in HOA patients and strongly correlated to PT, SS, and LL (i.e., as the PI increased so did the PT, SS, and LL). Sharp angles were also significantly greater in HOA patients and strongly correlated to age, LL and SS (i.e., as Sharp angles increased so did LL and SS); however, age decreased in the hip patients. Conclusions. These findings suggest that higher PI in the younger individual may contribute to the development of HOA in later life without both lumbar kyphosis and acetabular dysplasia because of the anterior uncovering of the acetabulum. More investigation will be expected to analyze the spinopelvic alignment in patients with hip spine syndrome.
Hong Kong Children's Concept of Distributive Justice

Previous research on the development of children's concept of distributive justice has shed little light on the child's ability to consider the characteristics of the recipients when making judgement of fair sharing. Previous research has shown that preschool children generally apply principles of equality when making decisions for fair sharing of materials, regardless of the characteristics of the recipients. The idea of equality refers to equal sharing of each individual person. The aim of the present study was to investigate whether preschool children would share toys equally across situations or on the basis of the characteristics of the recipients. The study also observed whether each member in a group would be counted as one unit for allocation across situations. A crucial piece of evidence for understanding children's concept of distributive justice is demonstrated by children's ability to view situations differently based on the characteristics of the recipients. These findings serve as a starting point to support the hypothesis that preschool children do take contextual information into account when making distributive justice decisions.