Miracle-dz/UniFAR-FTUs huggingface dataset:
Effective capacity of Nakagami-m fading channels with full channel state information in the low power regime

The effective capacity have been introduced by Wu and Neji as a link-layer model supporting statistical delay QoS requirements. In this paper, we propose to study the effective capacity of a Nakagami-m fading channel with full channel state information (CSI) at both the transmitter and at the receiver. We focus on the low Signal-to-Noise Ratio (SNR) regime. We show that the effective capacity for any arbitrary but finite statistically delay Quality of Service (QoS) exponent θ, scales essentially as S NRlog(1/SNR) exactly as the ergodic capacity, independently of any QoS constraint. We also characterize the minimum energy required for reliable communication, and the wideband slope to show that our results are in agreement with results established recently by Gursoy et al. We also propose an on-off power control scheme that achieves the capacity asymptotically using only one bit CSI feedback at the transmitter. Finally, some numerical results are presented to show the accuracy of our asymptotic results.
Translation and back-translation in qualitative nursing research: methodological review.

AIMS To examine the effects of the procedure of translation and the techniques used on the collection and interpretation of original language qualitative data for English presentation. BACKGROUND Nursing and health research increasingly use qualitative research for a broadened perspective on practice and research. In numerous qualitative nursing research papers, data are collected in the original language (example Chinese) and the findings are presented in English. No standardised procedures exist for evaluating the influences of translation on the trustworthiness of qualitative data in nursing research. DESIGN Translation and back-translation related literature review was conducted. METHODS This is a methodological review paper. Discussion. This paper discusses the factors influencing the quality of translation including translator, back-translation, culture and language. Additionally, the translation procedures reported in the literature and the author's experiences are considered. CONCLUSIONS The translation procedures described in qualitative nursing research can be summarised as: 1 Verbatim transcription of the content in original language, and then analysis of content; 2 Two bilingual translators are necessary to translate the emerged concepts and categories; 3 Back translate is employed; 4 An expert panel committee is involved in reaching final agreement on the translation. RELEVANCE TO CLINICAL PRACTICE Development of the translation procedures could provide qualitative nursing researchers with a guide when collecting data in one language and presenting results in another language. In this way, the necessary rigour in qualitative nursing research could be achieved.
FBXW7 Mediates Chemotherapeutic Sensitivity and Prognosis in NSCLCs

Non–small cell lung cancer (NSCLC) is a leading cause of cancer-related deaths worldwide. To improve the prognosis of patients with NSCLCs, new and validated therapeutic targets are critically needed. In this study, we focused on F-box and WD repeat domain containing-7 (FBXW7), an E3 ubiquitin ligase, that regulates the degradation of MCL1, Myc, cyclin E, and TOP2A. Importantly, loss of FBXW7 was associated with increased sensitivity of tumors to a class I–specific histone deacetylase (HDAC) inhibitor, MS-275. Immunohistochemical analysis revealed increased expression of FBXW7 targets, MCL1 and TOP2A, in NSCLC tumors with low expression of FBXW7. Moreover, clinical specimens exhibiting low FBXW7 expression presented with more progressive cancer and significantly shorter cancer-specific survival than patients with high FBXW7 expression. Mechanistic study of NSCLC cell lines with silenced FBXW7 revealed enhanced MS-275 sensitivity and taxol resistance. Interestingly, taxol resistance was eliminated by MS-275 treatment, suggesting the potential of HDAC inhibitors for the treatment of aggressive taxol-resistant NSCLCs that lack FBXW7. Implications: FBXW7 status impacts chemosensitivity and is a prognostic marker in NSCLCs. Visual Overview: http://mcr.aacrjournals. org/content/early/2013/12/19/1541-7786.MCR-13-0341/F1.large. jpg. Mol Cancer Res; 12(1); 32–37. ©2013 AACR.
Multicomponent Synthesis and Evaluation of New 1,2,3-Triazole Derivatives of Dihydropyrimidinones as Acidic Corrosion Inhibitors for Steel

An efficient one-pot synthesis of 1,2,3-triazole derivatives of dihydropyrimidinones has been developed using two multicomponent reactions. The aldehyde-1,2,3-triazoles were obtained in good yields from in situ-generated organic azides and O-propargylbenzaldehyde. The target heterocycles were synthesized through the Biginelli reaction in which the aldehyde-1,2,3-triazoles reacted with ethyl acetoacetate and urea in the presence of Ce(OTf)3 as the catalyst. The corrosion inhibition of steel grade API 5 L X52 in 1 M HCl by the synthesized compounds was investigated using the electrochemical impedance spectroscopy technique. The measurements revealed that these heterocycles are promising candidates to inhibit acidic corrosion of steel.
Derivation and characterization of Dicer- and microRNA-deficient human cells

Using gene editing, the authors have generated human cell lines lacking Dicer and found that these cells are essentially devoid of microRNAs. However, transfected synthetic microRNA duplexes rescue microRNA function and permit the identification of the mRNA targets of single microRNAs in the absence of endogenous microRNAs. The authors also show that the Drosophila Dicer1 protein, together with its cofactor Loqs-PB, is able to rescue human pre-microRNA processing, indicating strong functional conservation.
The answer is 17 years, what is the question: understanding time lags in translational research

This study aimed to review the literature describing and quantifying time lags in the health research translation process. Papers were included in the review if they quantified time lags in the development of health interventions. The study identified 23 papers. Few were comparable as different studies use different measures, of different things, at different time points. We concluded that the current state of knowledge of time lags is of limited use to those responsible for R&D and knowledge transfer who face difficulties in knowing what they should or can do to reduce time lags. This effectively ‘blindfolds’ investment decisions and risks wasting effort. The study concludes that understanding lags first requires agreeing models, definitions and measures, which can be applied in practice. A second task would be to develop a process by which to gather these data.
Inevitable Graphs and Profinite Topologies: Some Solutions to Algorithmic Problems in Monoid and Automata Theory, Stemming from Group Theory

This paper deals with several algorithmic problems in monoid and automata theory arising from group theory. For H a pseudovariety of groups, we give a characterization of the regular elements of the H-kernel of a finite monoid. In particular, we show that if the extension problem for partial one-to-one maps for H is decidable, then so is the set of regular elements of the H-kernel. The extension problem for partial one-to-one maps for H asks if there is an algorithm to determine, given a finite set X and a set S of partial one-to-one maps on X, whether there is a finite set Y containing X so that each of the maps of S can be extended to permutations of Y in such a manner that the group generated by these permutations is in H. This problem is decidable for the pseudovariety of p-groups and nilpotent groups. We explore some other examples here. We also show that if the above problem is decidable, then so is the membership problem for JⓜH. Some applications to the membership problem for J*H are given. Finally, we show that certain pseudovarieties of groups, including the pseudovarieties of p-groups for p prime, are hyperdecidable. The techniques used here lay the groundwork for several future results on problems of this nature.
Mitochondrial COI sequences in mites: evidence for variations in base composition

Studies of mitochondrial DNA sequences in a variety of animals have shown important differences between phyla, including differences in the genetic codes used, and varying constraints on base composition. In that respect, little is known of mites, an important and diversified group. We sequenced a portion (340 nt) of the cytochrome oxidase subunit I (COI) encoding gene in twenty species of phytophagous mites belonging to nine genera of the two families Tetranychidae and Tenuipalpidae. The mitochondrial genetic code used in mites appeared to be the same as in insects. As is generally also the case in insects, the mite sequences were very rich in A + T (75% on average), especially at the third codon position (94%). However, important variations of base composition were observed among mite species, one of them showing as little as 69% A + T. Variations of base composition occur mostly through synonymous transitions, and do not have detectable effects on polypeptide evolution in this group.
Trajectory analysis and semantic region modeling using a nonparametric Bayesian model

We propose a novel nonparametric Bayesian model, dual hierarchical Dirichlet processes (Dual-HDP), for trajectory analysis and semantic region modeling in surveillance settings, in an unsupervised way. In our approach, trajectories are treated as documents and observations of an object on a trajectory are treated as words in a document. Trajectories are clustered into different activities. Abnormal trajectories are detected as samples with low likelihoods. The semantic regions, which are intersections of paths commonly taken by objects, related to activities in the scene are also modeled. Dual-HDP advances the existing hierarchical Dirichlet processes (HDP) language model. HDP only clusters co-occurring words from documents into topics and automatically decides the number of topics. Dual-HDP co-clusters both words and documents. It learns both the numbers of word topics and document clusters from data. Under our problem settings, HDP only clusters observations of objects, while Dual-HDP clusters both observations and trajectories. Experiments are evaluated on two data sets, radar tracks collected from a maritime port and visual tracks collected from a parking lot.
Olfactomedin 2, a novel regulator for transforming growth factor-β–induced smooth muscle differentiation of human embryonic stem cell–derived mesenchymal cells

Smooth muscle plays important roles in vascular development. Study of smooth muscle differentiation of human embryonic stem cell–derived mesenchymal cells identifies olfactomedin 2 as a novel regulator. Olfactomedin 2 regulates smooth muscle gene transcription by empowering serum response factor binding to the CArG box in smooth muscle gene promoters.
Muscular strategy shift in human running: dependence of running speed on hip and ankle muscle performance

SUMMARY Humans run faster by increasing a combination of stride length and stride frequency. In slow and medium-paced running, stride length is increased by exerting larger support forces during ground contact, whereas in fast running and sprinting, stride frequency is increased by swinging the legs more rapidly through the air. Many studies have investigated the mechanics of human running, yet little is known about how the individual leg muscles accelerate the joints and centre of mass during this task. The aim of this study was to describe and explain the synergistic actions of the individual leg muscles over a wide range of running speeds, from slow running to maximal sprinting. Experimental gait data from nine subjects were combined with a detailed computer model of the musculoskeletal system to determine the forces developed by the leg muscles at different running speeds. For speeds up to 7 m s–1, the ankle plantarflexors, soleus and gastrocnemius, contributed most significantly to vertical support forces and hence increases in stride length. At speeds greater than 7 m s–1, these muscles shortened at relatively high velocities and had less time to generate the forces needed for support. Thus, above 7 m s–1, the strategy used to increase running speed shifted to the goal of increasing stride frequency. The hip muscles, primarily the iliopsoas, gluteus maximus and hamstrings, achieved this goal by accelerating the hip and knee joints more vigorously during swing. These findings provide insight into the strategies used by the leg muscles to maximise running performance and have implications for the design of athletic training programs.
Systems Approach to Studying Animal Sociality: Individual Position versus Group Organization in Dynamic Social Network Models

Social networks can be used to represent group structure as a network of interacting components, and also to quantify both the position of each individual and the global properties of a group. In a series of simulation experiments based on dynamic social networks, we test the prediction that social behaviors that help individuals reach prominence within their social group may conflict with their potential to benefit from their social environment. In addition to cases where individuals were able to benefit from improving both their personal relative importance and group organization, using only simple rules of social affiliation we were able to obtain results in which individuals would face a trade-off between these factors. While selection would favor (or work against) social behaviors that concordantly increase (or decrease, respectively) fitness at both individual and group level, when these factors conflict with each other the eventual selective pressure would depend on the relative returns individuals get from their social environment and their position within it. The presented results highlight the importance of a systems approach to studying animal sociality, in which the effects of social behaviors should be viewed not only through the benefits that those provide to individuals, but also in terms of how they affect broader social environment and how in turn this is reflected back on an individual's fitness.
Plant Diversity of the Cape Region of Southern Africa

Comprising a land area of ca. 90,000 km 2 , less than one twentieth (5%) the land area of the southern African subcontinent, the Cape Floristic Region (CFR) is, for its size, one of the world's richest areas of plant species diversity. A new synoptic flora for the Region has made possible an accurate reassessment of the flora, which has an estimated 9030 vascular plant species (68.7% endemic), of which 8920 species are flowering plants (69.5% endemic). The number of species packed into so small an area is remarkable for the temperate zone and compares favorably with species richness for areas of similar size in the wet tropics. The Cape region consists of a mosaic of sandstone and shale substrata with local areas of limestone. It has a highly dissected, rugged topography, and a diversity of climates with rainfall mostly falling in the winter months and varying from 2000 mm locally to less than 100 mm. Ecological gradients are steep as a result of abrupt differences in soil, altitude, aspect, and precipitation. These factors combine to form an unusually large number of local habitats for plants. Sandstone-derived soils have characteristically low nutrient status, and many plants present on such soils have low seed dispersal capabilities, a factor promoting localized distributions. An unusual family composition includes Iridaceae, Aizoaceae, Ericaceae, Scrophulariaceae, Proteaceae, Restionaceae, Rutaceae, and Orchidaceae among the 10 largest families in the flora, following Asteraceae and Fabaceae, as the most speciose families. Disproportionate radiation has resulted in over 59.2% species falling in the 10 largest families and 77.4% in the largest 20 families. Twelve genera have more than 100 species and the 20 largest genera contribute some 31% of the total species. Species richness of the Cape flora is hypothesized to be the result of geographic and parapatric radiation in an area with a mosaic of different habitats due to local soil, climate, and altitudinal differences that combine to produce steep ecological gradients. Also contributing to the diversity has been a relatively stable geological history since the end of the Miocene that saw the establishment of a semi-arid and extreme seasonal climate at the southwestern part of southern Africa.
Inactivation of aPKCλ results in the loss of adherens junctions in neuroepithelial cells without affecting neurogenesis in mouse neocortex

In developing mammalian telencephalon, the loss of adherens junctions and cell cycle exit represent crucial steps in the differentiation of neuroepithelial cells into neurons, but the relationship between these cellular events remains obscure. Atypical protein kinase C (aPKC) is known to contribute to junction formation in epithelial cells and to cell fate determination for Drosophila neuroblasts. To elucidate the functions of aPKCλ, one out of two aPKC members, in mouse neocortical neurogenesis, a Nestin-Cre mediated conditional gene targeting system was employed. In conditional aPKCλ knockout mice, neuroepithelial cells of the neocortical region lost aPKCλ protein at embryonic day 15 and demonstrated a loss of adherens junctions, retraction of apical processes and impaired interkinetic nuclear migration that resulted in disordered neuroepithelial tissue architecture. These results are evidence that aPKCλ is indispensable for the maintenance of adherens junctions and may function in the regulation of adherens junction integrity upon differentiation of neuroepithelial cells into neurons. In spite of the loss of adherens junctions in the neuroepithelium of conditional aPKCλ knockout mice, neurons were produced at a normal rate. Therefore, we concluded that, at least in the later stages of neurogenesis, regulation of cell cycle exit is independent of adherens junctions.
A categorical semantics of quantum protocols

Particular focus in this paper is on quantum information protocols, which exploit quantum-mechanical effects in an essential way. The particular examples we shall use to illustrate our approach will be teleportation (Benett et al., 1993), logic-gate teleportation (Gottesman and Chuang,1999), and entanglement swapping (Zukowski et al., 1993). The ideas illustrated in these protocols form the basis for novel and potentially very important applications to secure and fault-tolerant communication and computation (2001,1999,2000).
Diminishing Risk for Age-Related Macular Degeneration with Nutrition: A Current View

Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly. Clinical hallmarks of AMD are observed in one third of the elderly in industrialized countries. Preventative interventions through dietary modification are attractive strategies, because they are more affordable than clinical therapies, do not require specialists for administration and many studies suggest a benefit of micro- and macro-nutrients with respect to AMD with few, if any, adverse effects. The goal of this review is to provide information from recent literature on the value of various nutrients, particularly omega-3 fatty acids, lower glycemic index diets and, perhaps, some carotenoids, with regard to diminishing risk for onset or progression of AMD. Results from the upcoming Age-Related Eye Disease Study (AREDS) II intervention trial should be particularly informative.
Effect of global ocean temperature change on deep ocean ventilation

[1] A growing number of paleoceanographic observations suggest that the ocean’s deep ventilation is stronger in warm climates than in cold climates. Here we use a general ocean circulation model to test the hypothesis that this relation is due to the reduced sensitivity of seawater density to temperature at low mean temperature; that is, at lower temperatures the surface cooling is not as effective at densifying fresh polar waters and initiating convection. In order to isolate this factor from other climate-related feedbacks we change the model ocean temperature only where it is used to calculate the density (to which we refer below as ‘‘dynamic’’ temperature change). We find that a dynamically cold ocean is globally less ventilated than a dynamically warm ocean. With dynamic cooling, convection decreases markedly in regions that have strong haloclines (i.e., the Southern Ocean and the North Pacific), while overturning increases in the North Atlantic, where the positive salinity buoyancy is smallest among the polar regions. We propose that this opposite behavior of the North Atlantic to the Southern Ocean and North Pacific is the result of an energy-constrained overturning.
Formula Feeding Is Associated With Increased Hospital Admissions Due to Infections Among Infants Younger Than 6 Months in Manila, Philippines

This case control study evaluates the association between hospitalization due to infection and feeding practices among infants aged ≥ 3 days to < 6 months. Mothers of 191 cases hospitalized for infections and 208 healthy controls were interviewed using a standardized questionnaire documenting infant-feeding history. Results given in odds ratio and 95% confidence intervals (OR, 95% CI) were adjusted for age, education, and place of delivery. Exclusively formula-fed infants were more likely to be hospitalized for any infection (3.7, 1.8-7.5), pneumonia (3.0, 1.2-7.4), and diarrhea (10.5, 2.5-41.9) compared to exclusively breastfed infants. Infants who did not receive any breast milk were more likely to be hospitalized for any infection (3.5, 2.1-5.9), neonatal sepsis (4.9, 1.3-18.3), pneumonia (2.8, 1.5-5.4), and diarrhea (19.6, 6.5-58.6) than infants who received any breast milk. This study showed a strong positive association between the intake of formula and/or nonbreast milk supplements and the risk of hospitalization for infectious causes. J Hum Lact. 26(1):19-25.