Miracle-dz/UniFAR-FTUs huggingface dataset:
Role of Neopterin, C-Reactive Protein and Myeloperoxidase in Patients Undergoing Cardiopulmonary Bypass

Objective: The aim of the present study was to investigate the role of neopterin (NP), C-reactive protein (CRP) and myeloperoxidase (MPO) in patients undergoing coronary artery bypass grafting with or without cardiopulmonary bypass (CPB). Patients and Methods: Forty patients submitted for elective coronary artery bypass grafting were included in this prospective study. Patients were divided into two groups of 20 individuals, those who did not undergo CPB (group 1), aged 54.1 ± 13.5 years, and those who did (group 2), aged 60.2 ± 11.7 years. In group 1, there were 17 males and 3 females, while in group 2, there were 16 males and 4 females. Serum CRP, serum and urine NP and leukocyte MPO activity were measured preoperatively, at the end of surgery, and 4, 24 and 72 h after surgery using high-performance liquid chromatography, immunoturbidimetry and the reduction in o-dianizidine, respectively. Results: The level of serum NP was higher preoperatively and at the end of surgery (0 h), 4, 24, and 72 h after the operation in those who underwent CPB compared to those who did not. However, there was no significant difference in NP concentrations between the two groups at any time except 24 h after surgery (p = 0.002). Urine NP concentrations showed similar values preoperatively but increased postoperatively in both groups of patients. The only significant difference in urine NP concentration between the two groups occurred at 0 and 24 h after surgery (p = 0.001, p = 0.000). Serum CRP concentrations showed similar values preoperatively, at the end of surgery and 72 h after the operation and increased at 4 and 24 h postoperatively in both groups. The only significant difference in CRP concentration between the two groups occurred 4 and 24 h after surgery (p = 0.024 and p = 0.000, respectively). MPO levels were found to be increased in the CPB patients when compared to those patients who did not undergo CPB. However, the difference between the groups was not statistically significant. Conclusion: Our data show that CPB induced a rise in NP and CRP levels.
Clinical Ophthalmology Dovepress Comparison of 0.2% and 0.18% Hyaluronate Eye Drops in Patients with Moderate to Severe Dry Eye with Keratitis or Keratoconjunctivitis Patients and Methods Participants Study Design Prior and Concomitant Therapy Study Treatment Statistical Analysis

hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms Purpose: Comparison of efficacy and safety of 0.2% and 0.18% hyaluronic acid (HA) eye drops three times a day (tid) in patients with moderate to severe dry eye disease, related to keratitis or keratoconjunctivitis.inferiority study (0.2% HA vs 0.18% HA) in two parallel groups over a period of 84 days. N=70 patients were evaluated. Primary efficacy outcome was ocular surface (OS) staining change on day 35 (D35), compared to baseline. Fluorescein and lissamine green were used for staining of cornea and conjunctiva. Secondary efficacy outcome included tear film breakup time, OS staining score on day 84 (D84), ocular comfort index, as well as patients' and doctors' evaluation. Results: Compared to day 0 (D0), 0.2% HA achieved a 47.7% reduction in staining score (-3.00±2.81 [standard deviation] points, n=38 patients) at D35; 0.18% HA showed a 41.2% reduction (-2.59±2.20 [standard deviation] points, n=32 patients). Statistical analysis showed noninferiority in efficacy of 0.2% HA compared to 0.18% HA on D35. At D84, the reduction in staining score had further increased to 64.5% for 0.2% HA and to 56.4% for 0.18% HA. Both eye drops improved tear film breakup time and ocular comfort index values. Investigators and patients assessed both treatments with 5 of 7 points (Likert Scale, medians). The rate of adverse events (AE) was 2.3% for 0.2% HA and 7.1% for 0.18% HA with no serious AE. Conclusion: 0.2% and 0.18% HA eye drops significantly improved signs and symptoms of dry eye disease and were well tolerated with few AEs. Noninferiority of 0.2% HA compared to 0.18% HA was demonstrated for reduction of OS lesions. In some parameters, there was a nonsignificant trend in favor of 0.2% HA concentration. Introduction Dry eye disease (DED) is a multifactorial condition that affects tears and ocular surface (OS). DED can be associated with inflammation. 3 Lesions of the cornea and conjunctiva may occur, affecting the integrity of the OS. 1 Patients with DED may experience foreign body sensation, burning, itching and aching sensations, heavy eyes, fatigued eyes, and a decreased quality of vision, eg, stray light. 4 DED may also increase the risk of infections of the OS. 5 The current understanding …
Multi-omics Evidence for Inheritance of Energy Pathways in Red Blood Cells*

Each year over 90 million units of blood are transfused worldwide. Our dependence on this blood supply mandates optimized blood management and storage. During storage, red blood cells undergo degenerative processes resulting in altered metabolic characteristics which may make blood less viable for transfusion. However, not all stored blood spoils at the same rate, a difference that has been attributed to variable rates of energy usage and metabolism in red blood cells. Specific metabolite abundances are heritable traits; however, the link between heritability of energy metabolism and red blood cell storage profiles is unclear. Herein we performed a comprehensive metabolomics and proteomics study of red blood cells from 18 mono- and di-zygotic twin pairs to measure heritability and identify correlations with ATP and other molecular indices of energy metabolism. Without using affinity-based hemoglobin depletion, our work afforded the deepest multi-omic characterization of red blood cell membranes to date (1280 membrane proteins and 330 metabolites), with 119 membrane protein and 148 metabolite concentrations found to be over 30% heritable. We demonstrate a high degree of heritability in the concentration of energy metabolism metabolites, especially glycolytic metabolites. In addition to being heritable, proteins and metabolites involved in glycolysis and redox metabolism are highly correlated, suggesting that crucial energy metabolism pathways are inherited en bloc at distinct levels. We conclude that individuals can inherit a phenotype composed of higher or lower concentrations of these proteins together. This can result in vastly different red blood cells storage profiles which may need to be considered to develop precise and individualized storage options. Beyond guiding proper blood storage, this intimate link in heritability between energy and redox metabolism pathways may someday prove useful in determining the predisposition of an individual toward metabolic diseases.
Sour Sweets and Acidic Beverage Consumption Are Risk Indicators for Dental Erosion

This study aimed to investigate the association between dental erosive wear and potential background, behavioural and dietary risk indicators and to assess whether there is a dose-response relationship between the level of acidic beverage consumption and dental erosive wear among adolescents. Of 846 adolescents (aged 16-18 years) scheduled for dental recall examinations, 795 (94%) accepted to participate. All participants completed a self-administered questionnaire regarding their background (gender and age), tooth-brushing frequency and dietary habits (the amount and frequency of acidic food and beverage consumption as well as the chosen method and manner of consuming acidic drinks). The association between the presence of erosive lesions and the possible risk indicators was assessed by logistic regression analyses. Of all participants examined, 37% had ≥3 surfaces with dental erosions and were considered to be affected individuals. In the present study, multivariate logistic analyses revealed a significant association between the dental erosive wear and high consumption of sour sweets and sports drinks. The tooth-brushing frequency was not significantly associated with dental erosive wear. Additionally, to the best of our knowledge, the results are the first to indicate a dose-response relationship between the daily consumption of acidic drinks and dental erosive wear.
INTEGRAL and RXTE monitoring of GRS 1758-258 in 2003 and 2004. A transition from the dim soft state

The Galactic Center black hole candidate (BHC) GRS 1758-258 has been observed extensively within INTEGRAL's Galactic Center Deep Exposure (GCDE) program in 2003 and 2004, while also being monitored with RXTE. We present quasi-simultaneous PCA, ISGRI, and SPI spectra from four GCDE observation epochs as well as the evolution of energy-resolved PCA and ISGRI light curves on time scales of days to months. We find that during the first epoch GRS 1758-258 displayed another of its peculiar dim soft states like the one observed in 2001, increasing the number of observed occurrences of this state to three. During the other epochs the source was in the hard state. The hard X-ray emission component in the epoch-summed spectra can be well described either by phenomenological models, namely a cutoff power law in the hard state and a pure power law in the dim soft state, or by thermal Comptonization models. A soft thermal component is clearly present in the dim soft state and might also contribute to the softer hard state spectra. We argue that in the recently emerging picture of the hardness-intensity evolution of black hole transient outbursts in which hard and soft states are observed to occur in a large overlapping range of luminosities (hysteresis), the dim soft state is not peculiar. As noted before for the 2001 dim soft state, these episodes seem to be triggered by a sudden decrease (within days) of the hard emission, with the soft spectral component decaying on a longer time scale (weeks). We discuss this behavior as well as additional flux changes observed in the light curves in terms of the existence of two accretion flows characterized by different accretion time scales, the model previously suggested for the 2001 episode.
Terminal velocities of luminous, early-type SMC stars

Ultraviolet spectra from the Space Telescope Imaging Spectrograph (STIS) are used to determine terminal velocities for 11 O and B-type giants and supergiants in the Small Magellanic Cloud (SMC) from the Si IV and C IV resonance lines. Using archival data from observations with the Goddard High-Resolution Spectrograph and the International Ultraviolet Explorer telescope, terminal velocities are obtained for a further five B-type supergiants. We discuss the metallicity dependence of stellar terminal velocities, finding no evidence for a significant scaling between Galactic and SMC metallicities for Teff < 30,000 K, consistent with the predictions of radiation driven wind theory for supergiant stars. A comparison of the ratio $v_\infty / v_{esc}$ between the SMC and Galactic samples, while consistent with the above statement, emphasizes that the uncertainties in the distances to galactic O-stars are a serious obstacle to a detailed comparison with theory. Furthermore, for the SMC sample there is considerable scatter in this ratio at a given effective temperature, perhaps indicative of uncertainties in stellar masses.
Attractiveness Bias in the Evaluation of Young Pianists' Performances

We investigated how the attractiveness bias that influences the judgment of a variety of characteristics and behaviors in infants, children, and adults affects the evaluation of young pianists' performances. The assumption was that both the visual and the audio components of a videotaped musical performance influence the viewers perception of performance quality. We asked children, musicians, and nonmusicians (n = 75) to rate the quality of 10 piano performances from audiotapes (sound only) and from videotapes (sound and image). Additionally, the participants rated the attractiveness of the performers from brief videos of the performers getting ready to play. Results show that evaluations of audiovisual recordings of musical performances are judged more reliably than are audio recordings but also suggest that they may be affected by an attractiveness bias. The bias was found to favor the more attractive pianists among the female performers and among the best players, and the less attractive pianists among the male performers. The decision to use more reliable means of evaluation (videotapes or DVDs) at the expense of favoring a particular group of performers would have to be taken carefully depending on the outcomes of the situation.
Equipment requirments to facilitate contrast‐enhanced MR imaging

During the past decade, MR equipment and imaging techniques have experienced unprecedented development. Significant improvements have been made in image quality, enhancing conventional contrast agent studies. In addition, the development of new applications, such as MR angiography, has expanded the role of existing agents. A major benefit for contrast agent research has been the development of ultrafast MR imaging. This ability to provide information on contrast agent dynamics will aid in the detection and characterization of neoplastic and other disease states. While the gradient-echo techniques may provide adequate temporal resolution for many applications, echo planar imaging will enable the assessment of perfusion for an entire organ, which is critical in the heart or when the location of the pathology is unknown a priori. It is also likely that continued development in MR contrast agents will have a synergistic impact on pulse sequences, e.g., MR diffusion imaging. The growth in functional MR imaging will be based in large measure on the continued interactive development of imaging strategies and magnetopharmaceutials.
Differential Lateralization for Words and Faces: Category or Psychophysics?

This set of three experiments assessed the influence of different psychophysical factors on the lateralization of the N170 event-related potential (ERP) component to words and faces. In all experiments, words elicited a left-lateralized N170, whereas faces elicited a right-lateralized or nonlateralized N170 depending on presentation conditions. Experiment 1 showed that lateralization for words (but not for faces) was influenced by spatial frequency. Experiment 2 showed that stimulus presentation time influenced N170 lateralization independently of spatial frequency composition. Finally, Experiment 3 showed that stimulus size and resolution did not influence N170 lateralization, but did influence N170 amplitude, albeit differentially for words and faces. These findings suggest that differential lateralization for words and faces, at least as measured by the N170, is influenced by spatial frequency (words), stimulus presentation time, and category.
Common SNPs in HMGCR in Micronesians and Whites Associated With LDL-Cholesterol Levels Affect Alternative Splicing of Exon13

Background—Variation in LDL-cholesterol (LDL-C) among individuals is a complex genetic trait involving multiple genes and gene–environment interactions. Methods and Results—In a genome-wide association study (GWAS) to identify genetic variants influencing LDL-C in an isolated population from Kosrae, we observed associations for SNPs in the gene encoding 3hydroxy–3–methylglutaryl (HMG)-coenzyme A (CoA) reductase (HMGCR). Three of these SNPs (rs7703051, rs12654264, and rs3846663) met the statistical threshold of genome-wide significance when combined with data from the Diabetes Genetics Initiative GWAS. We followed up the association results and identified a functional SNP in intron13 (rs3846662), which was in linkage disequilibrium with the SNPs of genome-wide significance and affected alternative splicing of HMGCR mRNA. In vitro studies in human lymphoblastoid cells demonstrated that homozygosity for the rs3846662 minor allele was associated with up to 2.2-fold lower expression of alternatively spliced HMGCR mRNA lacking exon13, and minigene transfection assays confirmed that allele status at rs3846662 directly modulated alternative splicing of HMGCR exon13 (42.9±3.9 versus 63.7±1.0%&Dgr;exon13/total HMGCR mRNA, P=0.02). Further, the alternative splice variant could not restore HMGCR activity when expressed in HMGCR deficient UT-2 cells. Conclusion—We identified variants in HMGCR that are associated with LDL-C across populations and affect alternative splicing of HMGCR exon13.
Implications of the pragmatics of non-descriptive definition

This paper is a sequel to ‘Thematic predicates and the pragmatics of non-descriptive definition’ (Burton-Roberts, 1986, henceforth PNDD) and is best read in conjunction with it. I discuss a variety of issues arising out of the explanation there given of a phenomenon I called ‘non-descriptive definition’. In explaining non-descriptive definition, we need to explain how a definition-requesting question (e.g. What is a dandy? , (2) below) can be appropriately responded to by the utterance of a sentence that does not constitute a definition and, canonically at least, would actually presuppose knowledge of the meaning of the word to be defined (e.g. Max is a dandy? , (3) below). The explanation given depends on analysing such responses as having the predicate rather than the subject as theme. On the assumption that subject is unmarked theme, such responses thus have marked thematic structure. On the further assumption of a relation of pragmatic equivalence between an utterance with marked thematic structure and some unmarked counterpart, such responses may be straightforwardly related to strict literal ANSWERS to their definition-requesting questions; that is, they can be related to DEFINITIONS – non-descriptive in the first instance (see (4) below), and (explicit) descriptive definitions in the second (see (5) below).
Peripheries and borders: Pushing the boundaries of visual research

Abstract In my last paper for Inscape, ‘Ways in Which Photographic and Other Images are Used in Research: An Introductory Overview’ (July, 2012), I summarised the ways in which the arts are being used by social scientists. In this paper I look at less mainstream developments which are nevertheless of interest. In particular, I outline Iain Edgar's idea of ‘imagework’, which is the use of creative visualisation within research processes (although much of what he does is rather akin to some forms of art therapy). Probably less well documented and explored is the interesting borderline between social science research and personal therapy represented by both social art therapy and phototherapy, both of which will be explored in further detail. This paper is then contextualised with reference to other recent papers discussing the potential contribution of art therapy to social science, psychological and ethnographic research projects.
Prevalence of autism spectrum disorders in a total population sample.

OBJECTIVE Experts disagree about the causes and significance of the recent increases in the prevalence of autism spectrum disorders (ASDs). Limited data on population base rates contribute to this uncertainty. Using a population-based sample, the authors sought to estimate the prevalence and describe the clinical characteristics of ASDs in school-age children. METHOD The target population was all 7- to 12-year-old children (N=55,266) in a South Korean community; the study used a high-probability group from special education schools and a disability registry and a low-probability, general-population sample from regular schools. To identify cases, the authors used the Autism Spectrum Screening Questionnaire for systematic, multi-informant screening. Parents of children who screened positive were offered comprehensive assessments using standardized diagnostic procedures. RESULTS The prevalence of ASDs was estimated to be 2.64% (95% CI=1.91-3.37), with 1.89% (95% CI=1.43-2.36) in the general-population sample and 0.75% (95% CI=0.58-0.93) in the high-probability group. ASD characteristics differed between the two groups: the male-to-female ratios were 2.5:1 and 5.1:1 in the general population sample and high-probability group, respectively, and the ratios of autistic disorders to other ASD subtypes were 1:2.6 and 2.6:1, respectively; 12% in the general-population sample had superior IQs, compared with 7% in the high-probability group; and 16% in the general-population sample had intellectual disability, compared with 59% in the high-probability group. CONCLUSIONS Two-thirds of ASD cases in the overall sample were in the mainstream school population, undiagnosed and untreated. These findings suggest that rigorous screening and comprehensive population coverage are necessary to produce more accurate ASD prevalence estimates and underscore the need for better detection, assessment, and services.
A scanning electron microscope based new method for determining degree of substitution of sodium carboxymethyl cellulose

Na‐CMC or sodium carboxylmethyl cellulose is a water soluble anionic polymer obtained by introducing carboxymethyl groups along the cellulose chain. Na‐CMC is usually synthesized by the alkali catalyzed reaction of cellulose with monochloroacetic acid. The functional properties of Na‐CMC depend on the degree of substitution of the cellulose structure (i.e. how many of the hydroxyl groups are substituted per monomer unit), and also on the chain length of the cellulose backbone. The degree of substitution of Na‐CMC is usually determined according to ASTM D1439 which evolves the conversion of the Na‐CMC to free acid then again forming Na‐CMC by adding excess alkali and finally titrating the excess alkali with standard hydrochloric acid (0.3 N). The used volume of the standard alkali determines the degree of substitution. These existing chemical methods for determining the degree of substitution are not very convenient and very time‐consuming involving the use of hazardous chemicals. In this research, we have evaluated that the scanning electron microscope equipped with Energy Dispersive X‐Ray Analysis can be used to directly determine the degree of substitution.
Urban Public High School Teachers’ Beliefs about Science Learner Characteristics

This qualitative study addresses the link between urban high school teachers’ beliefs about their students’ preparedness to achieve success in science and the teachers’ reported curricular responses to those beliefs. Eight high school science teachers from schools representing a range of achievement levels were interviewed using semistructured, in-depth interview techniques. The findings suggest that teachers view science as a special subject that requires special qualities. Teachers saw their own students as largely lacking in those qualities needed for success in science and reported such modifications to the curriculum as “slowing down,” deemphasizing some topics, and reducing the depth of coverage.
Through the Prism of Critical Race Theory: Niceness and Latina/o Leadership in the Politics of Education

Utilizing a critical race theory (CRT) framework, I conduct a rhetorical and discursive analysis of data from a study of Utah Latino/a educational and political leaders. In analyzing how participants advocate closing the achievement gaps that affect Latina/o and Chicana/o students, I find that participants' political discourse is shaped by concepts such as “niceness,” “respect,” and “decorum,” which ultimately limits their critique and silences the experiences of students in their communities. I argue that CRT scholarship and practice frameworks play a vital role in enacting socially just policies and preparing educational leaders to engage critically in the politics of education.