Miracle-dz/UniFAR-FTUs huggingface dataset:
Symptomatic Aortic Stenosis: Does Systemic Hypertension Play an Additional Role?

Abstract— Hypertension and aortic stenosis represent 2 different models of left ventricular systolic overload. Previous studies have observed different remodeling patterns in these conditions. There is, however, little information about patients with coexisting aortic stenosis and hypertension. Echocardiography was performed in 193 consecutive patients with symptomatic aortic stenosis (113 males, 80 females; mean age, 68±9 years). The prevalence of systemic hypertension was assessed. Left ventricular mass index and relative wall thickness were measured from M‐mode echocardiography. Four different left ventricular remodeling patterns were identified: normal remodeling, concentric remodeling, concentric hypertrophy, and eccentric hypertrophy. A history of hypertension was present in 62 patients (32%), whereas 131 patients were normotensive. No significant differences were found between hypertensive and normotensive patients with respect to age, male/female ratio, mean New York Heart Association class, distribution of symptoms, left ventricular systolic and diastolic function, and remodeling patterns. In hypertensive patients, however, symptoms were present with larger aortic valve areas and lower stroke work loss. Systemic hypertension is not rare in patients with symptomatic aortic stenosis (32% in our series). Left ventricular remodeling patterns are quite similar in hypertensive and normotensive aortic stenosis. Our results suggest that symptoms of aortic stenosis develop with larger valve area and lower stroke work loss in hypertensive patients, probably because of the additional overload due to hypertension itself. It could suggest that in patients with coexisting hypertension and aortic stenosis, hypertension should be treated more aggressively to delay the occurrence of symptoms, and these patients should be followed‐up more closely.
Curricular design and implementation as a site of teacher expertise and learning

Previously, research about teacher expertise has adhered to relatively fixed notions of teacher expertise. However, in this study, we share data from teacher study group (TSG) meetings, which demonstrate a dynamic understanding of teacher expertise. In these meetings, teachers discursively positioned themselves, their colleagues, and the research team as both experts and learners as they engaged in a community of enquiry around questions of curriculum design and implementation. We argue that teachers’ dynamic and multiple positionings generated especially striking opportunities for learning. As teachers externalized their expert knowledge, their assumptions were brought forth to be examined, challenged, and reconsidered, thus opening space for further learning. We argue that these TSGs thus existed as a site for teacher learning, in which teacher dialog around curricular design, redesign, and the student learning that occurred in the lessons influenced their own learning about their students’ capabilities. We make a case for further research that explores how teacher expertise is interwoven with episodes of teacher learning. We assert that a complex understanding of teacher expertise, grounded in principles of learning occurring through social interaction, has important implications for how the field should move forward in its approach to fostering teacher learning throughout teachers’ careers.
Elaborating Indigenous Knowledge in the Science Curriculum for the Cultural Sustainability

Abstract Indigenous knowledge has been contrasted and compared with scientific knowledge as traditional versus modern. This becomes the main problem for the native learners who feel separated from their environment. They face the challenge of existing in a couple of worlds indigenous and non-indigenous. The research presents the theoretical viewpoints of science education and indigenous knowledge to provide a new perspective on science learning. Data are gathered through the original document analysis of indigenous communities of Javanese people and science syllabi. The results of the study propose four steps to integrate indigenous knowledge in the science curricula: fragmented, connected, sequenced, and integrated. This study indicates that indigenous knowledge incorporated in the science curricula includes attitude, knowledge, and skill aspects. It establishes a significant connection between what pupils encounter in the school and their lives beyond the school for the cultural sustainability. Elaborating indigenous knowledge in the science classroom is potential for building meaningful learning and connecting the gap of science education pathways that a student obtains in schools and community.
Surgical excision of the breast giant fibroadenoma under regional anesthesia by Pecs II and internal intercostal plane block: a case report and brief technical description: a case report

A 22-years-old female patient at 171 cm and 67 kg visited the Department of Breast Surgery of the hospital with a mass accompanied with pain on the left side breast as chief complaints. Since physical examination revealed a suspected huge mass, breast surgeon decided to perform surgical excision and requested anesthesia to our department. Surgery of breast tumor is often under local anesthesia. However, in case of big size tumor, surgery is usually performed under general anesthesia. The patient feared general anesthesia. Unlike abdominal surgery, there is no need to control visceral pain for breast and anterior thoracic wall surgery. Therefore, we decided to perform resection under regional anesthesia. Herein, we report a successful anesthetic and pain management of the patient undergoing excision of a huge breast fibroadenoma under regional anesthesia using Pecs II and internal intercostal plane block.
Meltwater Pulse 1A from Antarctica as a Trigger of the Bølling-Allerød Warm Interval

Meltwater pulse 1A (mwp-1A) was a prominent feature of the last deglaciation, which led to a sea-level rise of ∼20 meters in less than 500 years. Concurrent with mwp-1A was the onset of the Bølling-Allerød interstadial event (14,600 years before the present), which marked the termination of the last glacial period. Previous studies have been unable to reconcile a warm Northern Hemisphere with mwp-1A originating from the Laurentide or Fennoscandian ice sheets. With the use of a climate model of intermediate complexity, we demonstrate that with mwp-1A originating from the Antarctic Ice Sheet, consistent with recent sea-level fingerprinting inferences, the strength of North Atlantic Deep Water (NADW) formation increases, thereby warming the North Atlantic region and providing an explanation for the onset of the Bølling-Allerød warm interval. The established mode of active NADW formation is then able to respond to subsequent freshwater forcing from the Laurentide and Fennoscandian ice sheets, setting the stage for the Younger Dryas cold period.
The Proper Motion of the Arches Cluster with Keck Laser-Guide Star Adaptive Optics

We present the first measurement of the proper motion of the young, compact Arches cluster near the Galactic center from near-infrared adaptive optics (AO) data taken with the recently commissioned laser-guide star (LGS) at the Keck 10 m telescope. The excellent astrometric accuracy achieved with LGS-AO provides the basis for a detailed comparison with VLT/NAOS-CONICA data taken 4.3 yr earlier. Over the 4.3 yr baseline, a spatial displacement of the Arches cluster with respect to the field population is measured to be 24.0 ± 2.2 mas, corresponding to a proper motion of 5.6 ± 0.5 mas yr−1 or 212 ± 29 km s−1 at a distance of 8 kpc. In combination with the known line-of-sight velocity of the cluster, we derive a three-dimensional (3D) space motion of 232 ± 30 km s−1 of the Arches relative to the field. The large proper motion of the Arches cannot be explained with any of the closed orbital families observed in gas clouds in the bar potential of the inner Galaxy, but would be consistent with the Arches being on a transitional trajectory between x1 and x2 orbits. We investigate a cloud-cloud collision as the possible origin for the Arches cluster. The integration of the cluster orbit in the potential of the inner Galaxy suggests that the cluster passes within 10 pc of the supermassive black hole only if its true GC distance is very close to its projected distance. A contribution of young stars from the Arches cluster to the young stellar population in the inner few parsecs of the GC thus appears increasingly unlikely. The measurement of the 3D velocity and orbital analysis provides the first observational evidence that Arches-like clusters do not spiral into the GC. This confirms that no progenitor clusters to the nuclear cluster are observed at the present epoch.
Analysis of the Bacterial Communities in Two Liquors of Soy Sauce Aroma as Revealed by High-Throughput Sequencing of the 16S rRNA V4 Hypervariable Region

Chinese liquor is one of the world's oldest distilled alcoholic beverages and an important commercial fermented product in China. The Chinese liquor fermentation process has three stages: making Daqu (the starter), stacking fermentation on the ground, and liquor fermentation in pits. We investigated the bacterial diversity of Maotai and Guotai Daqu and liquor fermentation using high-throughput sequencing of the V4 hypervariable region of the 16S rRNA gene. A total of 70,297 sequences were obtained from the Daqu samples and clustered into 17 phyla. The composition of the bacterial communities in the Daqu from these two soy sauce aroma-style Chinese liquors was the same, although some bacterial species changed in abundance. Between the Daqu and liquor fermentation samples, 12 bacterial phyla increased. The abundance of Lactobacillus and Pseudomonas increased in the liquor fermentation. This study has used high-throughput sequencing to provide new insights into the bacterial composition of the Chinese liquor Daqu and fermentation. Similarities in the distribution of bacteria in the soy sauce aroma-style Chinese liquors Daqu suggest that the abundance of bacteria might be generally concerned to other liquor.
euL1db: the European database of L1HS retrotransposon insertions in humans

Retrotransposons account for almost half of our genome. They are mobile genetics elements—also known as jumping genes—but only the L1HS subfamily of Long Interspersed Nuclear Elements (LINEs) has retained the ability to jump autonomously in modern humans. Their mobilization in germline—but also some somatic tissues—contributes to human genetic diversity and to diseases, such as cancer. Here, we present euL1db, the European database of L1HS retrotransposon insertions in humans (available at http://euL1db.unice.fr). euL1db provides a curated and comprehensive summary of L1HS insertion polymorphisms identified in healthy or pathological human samples and published in peer-reviewed journals. A key feature of euL1db is its sample-wise organization. Hence L1HS insertion polymorphisms are connected to samples, individuals, families and clinical conditions. The current version of euL1db centralizes results obtained in 32 studies. It contains >900 samples, >140 000 sample-wise insertions and almost 9000 distinct merged insertions. euL1db will help understanding the link between L1 retrotransposon insertion polymorphisms and phenotype or disease.
Inter- and Intra-Subunit Butanol/Isoflurane Sites of Action in the Human Glycine Receptor

Glycine receptors (GlyRs) mediate inhibitory neurotransmission and are targets for alcohols and anesthetics in brain. GlyR transmembrane (TM) domains contain critical residues for alcohol/anesthetic action: amino acid A288 in TM3 forms crosslinks with TM1 (I229) in the adjacent subunit as well as TM2 (S267) and TM4 (Y406, W407, I409, Y410) in the same subunit. We hypothesized that these residues may participate in intra-subunit and inter-subunit sites of alcohol/anesthetic action. The following double and triple mutants of GLRA1 cDNA (encoding human glycine receptor alpha 1 subunit) were injected into Xenopus laevis oocytes: I229C/A288C, I229C/A288C/C290S, A288C/Y406C, A288C/W407C, A288C/I409C, and A288C/Y410C along with the corresponding single mutants and wild-type GLRA1. Butanol (22 mM) or isoflurane (0.6 mM) potentiation of GlyR-mediated currents before and after application of the cysteine crosslinking agent HgCl2 (10 μM) was measured using two-electrode voltage clamp electrophysiology. Crosslinking nearly abolished butanol and isoflurane potentiation in the I229C/A288C and I229C/A288C/C290S mutants but had no effect in single mutants or wild-type. Crosslinking also inhibited butanol and isoflurane potentiation in the TM3-4 mutants (A288C/Y406C, A288C/W407C, A288C/I409C, A288C/Y410C) with no effect in single mutants or wild-type. We extracted proteins from oocytes expressing I229C/288C, A288C/Y410C, or wild-type GlyRs, used mass spectrometry to verify their expression and possible inter-subunit dimerization, plus immunoblotting to investigate the biochemical features of proposed crosslinks. Wild-type GlyR subunits measured about 50 kDa; after crosslinking, the dimeric/monomeric 100:50 kDa band ratio was significantly increased in I229C/288C but not A288C/Y410C mutants or wild-type, providing support for TM1-3 inter-subunit and TM3-4 intra-subunit crosslinking. A GlyR homology model based on the GluCl template provides further evidence for a multi-site model for alcohol/anesthetic interaction with human GLRA1.
Observing Virtual Arms that You Imagine Are Yours Increases the Galvanic Skin Response to an Unexpected Threat

Multi-modal visuo-tactile stimulation of the type performed in the rubber hand illusion can induce the brain to temporarily incorporate external objects into the body image. In this study we show that audio-visual stimulation combined with mental imagery more rapidly elicits an elevated physiological response (skin conductance) after an unexpected threat to a virtual limb, compared to audio-visual stimulation alone. Two groups of subjects seated in front of a monitor watched a first-person perspective view of slow movements of two virtual arms intercepting virtual balls rolling towards the viewer. One group was instructed to simply observe the movements of the two virtual arms, while the other group was instructed to observe the virtual arms and imagine that the arms were their own. After 84 seconds the right virtual arm was unexpectedly “stabbed” by a knife and began “bleeding”. This aversive stimulus caused both groups to show a significant increase in skin conductance. In addition, the observation-with-imagery group showed a significantly higher skin conductance (p<0.05) than the observation-only group over a 2-second period shortly after the aversive stimulus onset. No corresponding change was found in subjects' heart rates. Our results suggest that simple visual input combined with mental imagery may induce the brain to measurably temporarily incorporate external objects into its body image.
Tales from the front lines of a large-scale serious game project

Serious games have received much positive attention; correspondingly, many researchers have taken up the challenge of establishing how to best design them. However, the current literature often focuses on best practice design strategies and frameworks. Fine-grained details, contextual descriptions, and organisational factors that are invaluable in helping us to learn from and reflect on project experiences are often overlooked. In this paper, we present five distinct and sometimes competing perspectives that are critical in understanding factors that influence serious game projects: project organisation, technology, domain knowledge, user research, and game design. We explain these perspectives by providing insights from the design and development process of an EU-funded serious game about conflict resolution developed by an interdisciplinary consortium of researchers and industry-based developers. We also point out a set of underlying forces that become evident from viewing the process from different perspectives, to underscore that problems exist in serious game projects and that we should open the conversation about them.
Expectancies as mediators of the effects of social influences and alcohol knowledge on adolescent alcohol use: A prospective analysis.

Expectancies play an important role in the generation of adolescent alcohol use. However, few studies have precisely elucidated their role when specified with other prominent measures of social influences, which may also independently promote alcohol use. Three-year panel data and path-analytic techniques were used to test a model positing that social reinforcement expectancies mediate the effects of perceived friends' alcohol use, friends' alcohol attitudes, and knowledge of near-term health effects and alcohol prevalence on both contemporaneous and subsequent alcohol involvement. Evidence of mediation was obtained with both cross-sectional and longitudinal findings. Perceived peer norms had a direct effect on alcohol use, and knowledge of normative alcohol use had a unique long-term protective influence on later alcohol use. Findings are discussed in terms of a 2-pronged prevention model that (a) integrates principles of social learning theory with expectancy-based, cognitive-behavioral change and (b) emphasizes dissemination of age-appropriate alcohol information in programs that aim to reduce alcohol use.
Spatio-temporal Saliency detection using phase spectrum of quaternion fourier transform

Salient areas in natural scenes are generally regarded as the candidates of attention focus in human eyes, which is the key stage in object detection. In computer vision, many models have been proposed to simulate the behavior of eyes such as SaliencyToolBox (STB), neuromorphic vision toolkit (NVT) and etc., but they demand high computational cost and their remarkable results mostly rely on the choice of parameters. Recently a simple and fast approach based on Fourier transform called spectral residual (SR) was proposed, which used SR of the amplitude spectrum to obtain the saliency map. The results are good, but the reason is questionable.
A new planar multielectrode array: recording from a rat auditory cortex

In the study of the spatiotemporal properties of the cortex, a demand often arises for recording local field evoked potentials (LFEP) and neural spikes from a quantity of points at close range from each other. In such a situation a device composed of a lot of electrodes assembled in a single bunch would be suitable. Such circumstances gave us the impetus to create the device described in this paper, namely a new planar electrode array for in vivo multisite extracellular recording. The device is made of plastic and includes platinum electrodes 50 µm in diameter. The array of 64 incorporated microelectrodes is placed on the surface of the cortex of anesthetized rats. Recordings could be made through all electrodes for more than 1 h without damage to the cortex. The inter-polar distance is approximately 100 µm so that each individual electrode can record activity from a separate population of neurons near the cortical surface. The recording system described here is highly useful for visualizing spatiotemporal structure of the cortical activities and for imaging dynamic neuronal assemblies.
The Gender Gap in Mathematics: Evidence from Low- and Middle-Income Countries

We establish the presence of a gender gap in mathematics across many low- and middle-income countries using detailed, comparable test score data. Examining micro level data on school performance linked to household demographics we note that first, the gender gap appears to increase with age. Indeed, the gap nearly doubles when comparing 4th grade and 8th grade test scores. Second, we test whether commonly proposed explanations such as parental background and investments, unobserved ability, and classroom environment (including teacher gender) explain a substantial portion of the gap. While none of these explanations help in substantially explaining the gender gap we observe, we show that boys and girls differ significantly in perceptions about their own ability in math, conditional on math test scores. Girls are much more likely to state that they dislike math, or find math difficult compared to boys. We highlight differences in self-assessed ability as areas for future research that might lead to a better understanding of the gender gap in math.
Fragmentation of Contaminant and Endogenous DNA in Ancient Samples Determined by Shotgun Sequencing; Prospects for Human Palaeogenomics

Background Despite the successful retrieval of genomes from past remains, the prospects for human palaeogenomics remain unclear because of the difficulty of distinguishing contaminant from endogenous DNA sequences. Previous sequence data generated on high-throughput sequencing platforms indicate that fragmentation of ancient DNA sequences is a characteristic trait primarily arising due to depurination processes that create abasic sites leading to DNA breaks. Methodology/Principals Findings To investigate whether this pattern is present in ancient remains from a temperate environment, we have 454-FLX pyrosequenced different samples dated between 5,500 and 49,000 years ago: a bone from an extinct goat (Myotragus balearicus) that was treated with a depurinating agent (bleach), an Iberian lynx bone not subjected to any treatment, a human Neolithic sample from Barcelona (Spain), and a Neandertal sample from the El Sidrón site (Asturias, Spain). The efficiency of retrieval of endogenous sequences is below 1% in all cases. We have used the non-human samples to identify human sequences (0.35 and 1.4%, respectively), that we positively know are contaminants. Conclusions We observed that bleach treatment appears to create a depurination-associated fragmentation pattern in resulting contaminant sequences that is indistinguishable from previously described endogenous sequences. Furthermore, the nucleotide composition pattern observed in 5′ and 3′ ends of contaminant sequences is much more complex than the flat pattern previously described in some Neandertal contaminants. Although much research on samples with known contaminant histories is needed, our results suggest that endogenous and contaminant sequences cannot be distinguished by the fragmentation pattern alone.
Protein design simulations suggest that side‐chain conformational entropy is not a strong determinant of amino acid environmental preferences

Loss of side‐chain conformational entropy is an important force opposing protein folding and the relative preferences of the amino acids for being buried or solvent exposed may be partially determined by which amino acids lose more side‐chain entropy when placed in the core of a protein. To investigate these preferences, we have incorporated explicit modeling of side‐chain entropy into the protein design algorithm, RosettaDesign. In the standard version of the program, the energy of a particular sequence for a fixed backbone depends only on the lowest energy side‐chain conformations that can be identified for that sequence. In the new model, the free energy of a single amino acid sequence is calculated by evaluating the average energy and entropy of an ensemble of structures generated by Monte Carlo sampling of amino acid side‐chain conformations. To evaluate the impact of including explicit side‐chain entropy, sequences were designed for 110 native protein backbones with and without the entropy model. In general, the differences between the two sets of sequences are modest, with the largest changes being observed for the longer amino acids: methionine and arginine. Overall, the identity between the designed sequences and the native sequences does not increase with the addition of entropy, unlike what is observed when other key terms are added to the model (hydrogen bonding, Lennard‐Jones energies, and solvation energies). These results suggest that side‐chain conformational entropy has a relatively small role in determining the preferred amino acid at each residue position in a protein. Proteins 2006. © 2005 Wiley‐Liss, Inc.