Miracle-dz/UniFAR-FTUs huggingface dataset:
Distinct Pathways Involved in Sound Recognition and Localization: A Human fMRI Study

Evidence from psychophysical studies in normal and brain-damaged subjects suggests that auditory information relevant to recognition and localization are processed by distinct neuronal populations. We report here on anatomical segregation of these populations. Brain activation associated with performance in sound identification and localization was investigated in 18 normal subjects using fMRI. Three conditions were used: (i) comparison of spatial stimuli simulated with interaural time differences; (ii) identification of environmental sounds; and (iii) rest. Conditions (i) and (ii) required acknowledgment of predefined targets by pressing a button. After coregistering, images were normalized and smoothed. Activation patterns were analyzed using SPM99 for individual subjects and for the whole group. Sound recognition and localization activated, as compared to rest, inferior colliculus, medial geniculate body, Heschl gyrus, and parts of the temporal, parietal, and frontal convexity bilaterally. The activation pattern on the fronto-temporo-parietal convexity differed in the two conditions. Middle temporal gyrus and precuneus bilaterally and the posterior part of left inferior frontal gyrus were more activated by recognition than by localization. Lower part of inferior parietal lobule and posterior parts of middle and inferior frontal gyri were more activated, bilaterally, by localization than by recognition. Regions selectively activated by sound recognition, but not those selectively activated by localization, were significantly larger in women. Passive listening paradigm revealed segregated pathways on superior temporal gyrus and inferior parietal lobule. Thus, anatomically distinct networks are involved in sound recognition and sound localization.
Long-Term Preservation of Mouse Spermatozoa after Freeze-Drying and Freezing Without Cryoprotection1

Abstract The widespread production of mice with transgenes, disrupted genes and mutant genes, has strained the resources available for maintaining these mouse lines as live populations, and dependable methods for gamete and embryo preservation in these lines are needed. Here we report the results of intracytoplasmic sperm injection (ICSI) with spermatozoa freeze-dried or frozen without a cryoprotectant after storage for periods up to 1.5 years. Freeze-dried samples were stored at 4°C. Samples frozen without cryoprotection were maintained at −196°C. After storage, spermatozoa were injected into the oocytes by ICSI. Zygotic chromosomes and fetal development at Day 15 of gestation were examined after 0, 1, 3, 6, 9, and 12 mo of sperm storage. When fresh spermatozoa were used for ICSI, 96% of resultant zygotes contained normal chromosomes, and 58% of two-cell embryos transferred developed to normal viable fetuses. Similar results were obtained when spermatozoa were frozen without cryoprotection and then used for ICSI (87% and 45%, respectively; P > 0.05) and after 12 mo of sperm storage (mean of six endpoints examined: 87% and 52%, respectively; P > 0.05). Freeze-drying decreased the proportion of zygotes with normal karyoplates (75% vs. 96%; P < 0.001) and the proportion of embryos that developed into fetuses (35% vs. 58%; P < 0.001), but similar to freezing, there was no further deterioration during 12 mo of storage (mean of six endpoints examined: 68% and 34%, respectively; P > 0.05). Live offspring were obtained from both freeze-dried and frozen spermatozoa after storage for 1.5 yr. The results indicate that 1) the freeze-drying procedure itself causes some abnormalities in spermatozoa but freezing without cryoprotection does not and 2) long-term storage of both frozen and freeze-dried spermatozoa is not deleterious to their genetic integrity. Freezing without cryoprotection is highly successful, simple, and efficient but, like all routine sperm storage methods, requires liquid nitrogen. Liquid nitrogen is also required for freeze-drying, but sperm can then be stored at 4°C and shipped at ambient temperatures. Both preservation methods are successful, but rapid freezing without cryoprotection is the preferred method for preservation of spermatozoa from mouse strains carrying unique genes and mutations.
Number Density Evolution of Ks-Band-Selected High-Redshift Galaxy Populations in the AKARI North Ecliptic Pole Field

We present the number counts of Ks-band-selected high-redshift galaxy populations such as extremely red objects (EROs), B-, z-, and K-band-selected galaxies (BzKs) and distant red galaxies (DRGs) in the AKARI NEP field. These high-redshift galaxy samples are extracted from a multicolor catalog combining optical data from Suprime-Cam on the 8.2 m Subaru Telescope with near-infrared data from the Florida Multiobject Imaging Near-IR Grism Observational Spectrometer on the Kitt Peak National Observatory 2.1 m telescope over 540 arcmin2 in the NEP region field. The final catalog contains 308 EROs (Ks < 19.0; 54% are dusty star-forming EROs, and the rest are passive old EROs), 137 star-forming BzKs, and 38 passive old BzKs (Ks < 19.0) and 64 DRGs (Ks < 18.6). We also produce individual component source counts for both the dusty star-forming and passive populations. We compare the observed number counts of the high redshift passively evolving galaxy population with a backward pure luminosity evolution (PLE) model allowing different degrees of number density evolution. We find that the PLE model without density evolution fails to explain the observed counts at faint magnitudes, while the model incorporating negative density evolution is consistent with the observed counts of the passively evolving population. We also compare our observed counts of dusty star-forming EROs with a phenomenological evolutionary model postulating that the near-infrared EROs can be explained by the source densities of the far-infrared-submillimeter populations. Our model predicts that the dusty ERO source counts can be explained assuming a 25% contribution of submillimeter star-forming galaxies with the majority of brighter Ks-band-detected dusty EROs having luminous (rather than HR 10 type ultraluminous) submillimeter counterparts. We propose that the fainter Ks > 19.5 population is dominated by the submillijansky submillimeter population. We also predict a turnover in dusty ERO counts around 19 < Ks < 20.
Ine ffi cient Credit Booms

This paper studies the welfare properties of competitive equilibria in an economy with financial frictions hit by aggregate shocks. In particular, it shows that competitive financial contracts can result in excessive borrowing ex ante and excessive volatility ex post. Even though, from a first-best perspective the equilibrium always displays under-borrowing, from a second-best point of view excessive borrowing can arise. The inefficiency is due to the combination of limited commitment in financial contracts and the fact that asset prices are determined in a spot market. This generates a pecuniary externality that is not internalized in private contracts. The model provides a framework to evaluate preventive policies which can be used during a credit boom to reduce the expected costs of a financial crisis.
Four-Valued Reasoning and Cyclic Circuits

Allowing cycles in a logic circuit can be advantageous, for example, by reducing the number of gates required to implement a given Boolean function, or a set of functions. However, a cyclic circuit may easily be ill behaved. For instance, it may have some output wire oscillation instead of reaching a steady state. Propositional three-valued logic has long been used in tests for good behavior of cyclic circuits; a symbolic evaluation method known as ternary analysis provides one criterion for good behavior under certain assumptions about wire and gate delay. We revisit ternary analysis and argue for the use of four truth values. The fourth truth value allows for the distinction of undefined and underspecified behavior. Ability to under specify behavior is useful, because, in a quest for smaller circuits, an implementor can capitalize on degrees of freedom offered in the specification. Moreover, a fourth truth value is attractive because, rather than complicating (ternary) circuit analysis, it introduces a pleasant symmetry, in the form of contra-duality, as well as providing a convenient framework for manipulating specifications. We use this symmetry to provide fixed point results that clarify how two-, three-, and four-valued analyses are related, and to explain some observations about ternary analysis.
Sleep spindle alterations in patients with Parkinson's disease

The aim of this study was to identify changes of sleep spindles (SS) in the EEG of patients with Parkinson's disease (PD). Five sleep experts manually identified SS at a central scalp location (C3-A2) in 15 PD and 15 age- and sex-matched control subjects. Each SS was given a confidence score, and by using a group consensus rule, 901 SS were identified and characterized by their (1) duration, (2) oscillation frequency, (3) maximum peak-to-peak amplitude, (4) percent-to-peak amplitude, and (5) density. Between-group comparisons were made for all SS characteristics computed, and significant changes for PD patients vs. control subjects were found for duration, oscillation frequency, maximum peak-to-peak amplitude and density. Specifically, SS density was lower, duration was longer, oscillation frequency slower and maximum peak-to-peak amplitude higher in patients vs. controls. We also computed inter-expert reliability in SS scoring and found a significantly lower reliability in scoring definite SS in patients when compared to controls. How neurodegeneration in PD could influence SS characteristics is discussed. We also note that the SS morphological changes observed here may affect automatic detection of SS in patients with PD or other neurodegenerative disorders (NDDs).
Analyses of more than 60,000 exomes questions the role of numerous genes previously associated with dilated cardiomyopathy

Hundreds of genetic variants have been described as disease causing in dilated cardiomyopathy (DCM). Some of these associations are now being questioned. We aimed to identify the prevalence of previously DCM associated variants in the Exome Aggregation Consortium (ExAC), in order to identify potentially false‐positive DCM variants.
From Posting to Voting: The Effects of Political Competition on Online Political Engagement

How does living in a battleground state during a presidential election affect an individual's political engagement? We utilize a unique collection of 113 million status updates on Facebook to answer this persistent question in the study of political behavior by comparing users’ political discussion during the 2008 presidential election in politically competitive versus uncompetitive states. "Battleground" state users are significantly more likely to discuss politics in the campaign season than are "blackout" state users, and posting a political status update --- a form of day-to-day engagement with politics --- affects a person’s self-reported voter turnout, mediating approximately 20% of the relationship between exposure to political competition and turnout. While our results can only be generalized to the tens of millions of Facebook users and not the entire American voting age population, this paper is one of the first efforts to use the massive quantity of data generated through online social media sites to explain the microfoundations of how people think, feel, and act on a daily basis in response to their political environment.
New and emerging risk factors for CVD

Morphological and immunocytochemical studies have elucidated the complex processes involved in atherogenesis. The notion of plaque instability has emerged from this work and underscored the importance of inflammation in determining clinical complications associated with atherosclerosis, such as acute coronary syndrome. Cells of the immune system have been detected within atherosclerotic lesions and auto-antibodies directed against modified LDL and heat-shock proteins have been identified in the blood of individuals with atherosclerosis. The use of risk ‘engines’, e.g. the Framingham coronary risk score, has facilitated the identification of individuals at high risk, but the constituent classical risk factors used in these algorithms do not adequately differentiate individuals at moderate risk. As age is a major component of the equations used in these algorithms they are not particularly useful in young adults, and their applicability to non-Caucasian populations has been questioned. Biomarkers of early disease and plaque instability have therefore both been sought. Although some of these markers have been shown individually to be associated with a significant hazard ratio, no substantial improvement in discrimination has been demonstrated when they are incorporated into a risk ‘engine’. The latter has generally been assessed by receiver operator characteristic curve analysis, although this approach has been criticised. Other modalities, including imaging and functional assessments of vascular function, are now being developed for clinical use.
Work-family conflict and retirement preferences.

OBJECTIVES This study investigates relationships between retirement preferences and perceived levels of work-family conflict. METHODS Using the large sample of 52-54-year-old respondents to the 1992 Wisconsin Longitudinal Study, we estimated multinomial logistic regression models of preferences for partial and full retirement within the next 10 years. We examined the association between retirement preferences and perceived work-family conflict, evaluated the extent to which work-family conflict was a mediating mechanism between stressful work and family circumstances and preferences to retire, and explored potential gender differences in the association between work-family conflict and preferring retirement. RESULTS Work-family conflict was positively related to preferences for both full and partial retirement. Yet work-family conflict did not appear to mediate relationships between stressful work and family environments and retirement preferences, nor did significant gender differences emerge in this association. DISCUSSION Our analyses provide the first direct evidence of the role played by work-family conflict in the early stages of the retirement process, although we were not able to identify the sources of conflict underlying this relationship. Identifying the sources of this conflict and the psychological mechanisms linking work-family conflict to retirement preferences is an important task for future researchers.
From IT Investment to Firm Market Value: The Mediating Role of Stock Analysts' Recommendation

This study provides a new perspective to the long-standing debate on the business value of IT. Advancing prior research on the internal perspectives of IT value creation, we take an external view and investigate the role of stock analysts in facilitating the market evaluation of firms’ IT investments. Stock analysts collect information about firms’ IT investments and provide informed recommendations to investors in the financial market. As IT investments are known for their complexity and inherent risks, stock analysts can reduce information asymmetry between the firm and investors in the financial markets, thus helping discovering the business value of IT investments. On the basis of Fortune 1000 firms between 1996 and 2007, our analysis suggests that stock analysts play an intricate mediating role in the stock market evaluation of IT investments. Analyst recommendations have a strong mediating role in the effects of enterprise IT systems (ERP and CRM) on firm market value, but a weak to insignificant mediating role in the effects of function IT systems (DSS, HR and AIS). In addition, we find that the mediating role of financial analysts for IT investments is more salient when the firm’s market environments are more uncertain and unpredictable. These findings suggest that analyst recommendations play a critical role in the stock market valuation of firms’ IT investments in situations where the value of such investments is difficult to assess.
Increased Expression of HCN Channels in the Ventricular Myocardium Contributes to Enhanced Arrhythmicity in Mouse Failing Hearts

Background The efficacy of pharmacological interventions to prevent sudden arrhythmic death in patients with chronic heart failure remains limited. Evidence now suggests increased ventricular expression of hyperpolarization‐activated cation (HCN) channels in hypertrophied and failing hearts contributes to their arrythmicity. Still, the role of induced HCN channel expression in the enhanced arrhythmicity associated with heart failure and the capacity of HCN channel blockade to prevent lethal arrhythmias remains undetermined. Methods and Results We examined the effects of ivabradine, a specific HCN channel blocker, on survival and arrhythmicity in transgenic mice (dnNRSF‐Tg) expressing a cardiac‐specific dominant‐negative form of neuron‐restrictive silencer factor, a useful mouse model of dilated cardiomyopathy leading to sudden death. Ivabradine (7 mg/kg per day orally) significantly reduced ventricular tachyarrhythmias and improved survival among dnNRSF‐Tg mice while having no significant effect on heart rate or cardiac structure or function. Ivabradine most likely prevented the increase in automaticity otherwise seen in dnNRSF‐Tg ventricular myocytes. Moreover, cardiac‐specific overexpression of HCN2 in mice (HCN2‐Tg) made hearts highly susceptible to arrhythmias induced by chronic β‐adrenergic stimulation. Indeed, ventricular myocytes isolated from HCN2‐Tg mice were highly susceptible to β‐adrenergic stimulation‐induced abnormal automaticity, which was inhibited by ivabradine. Conclusions HCN channel blockade by ivabradine reduces lethal arrhythmias associated with dilated cardiomyopathy in mice. Conversely, cardiac‐specific overexpression of HCN2 channels increases arrhythmogenicity of β‐adrenergic stimulation. Our findings demonstrate the contribution of HCN channels to the increased arrhythmicity seen in failing hearts and suggest HCN channel blockade is a potentially useful approach to preventing sudden death in patients with heart failure.
Oncology nurses' attitudes toward prognosis-related communication: a pilot mailed survey of oncology nursing society members.

PURPOSE/OBJECTIVES To assess oncology nurses' attitudes toward prognosis-related communication and experiences of the quality of such communication among physicians. DESIGN Cross-sectional study. SETTING Nationwide survey in the United States. SAMPLE 394 Oncology Nursing Society members who completed surveys. METHODS Pilot mailed survey. MAIN RESEARCH VARIABLES Demographic variables, measures of attitudes toward and experiences of prognosis-related communication. FINDINGS Nurses had mixed views of prognosis-related communication and identified common barriers to their own more effective participation in prognosis-related communication. Nurses with more experience and those who worked in inpatient settings were more likely to be present for physicians' prognosis-related communication with patients. CONCLUSIONS Respondents identified uncertainties regarding the scope of oncology nurses' role in prognosis-related communication. Respondents also identified opportunities for improved interdisciplinary communication, most importantly the inclusion of oncology nurses in prognosis-related communication. IMPLICATIONS FOR NURSING Opportunities for oncology nurses to bridge some gaps in prognosis-related communication likely exist, although barriers surrounding nurses' role, education, and communication within the context of the larger healthcare team need to be clarified if potential solutions are to be developed.
Child Centred Approach to Climate Change and Health Adaptation through Schools in Bangladesh: A Cluster Randomised Intervention Trial

Background Bangladesh is one of the most vulnerable countries to climate change. People are getting educated at different levels on how to deal with potential impacts. One such educational mode was the preparation of a school manual, for high school students on climate change and health protection endorsed by the National Curriculum and Textbook Board, which is based on a 2008 World Health Organization manual. The objective of this study was to test the effectiveness of the manual in increasing the knowledge level of the school children about climate change and health adaptation. Methods This cluster randomized intervention trial involved 60 schools throughout Bangladesh, with 3293 secondary school students participating. School upazilas (sub-districts) were randomised into intervention and control groups, and two schools from each upazila were randomly selected. All year seven students from both groups of schools sat for a pre-test of 30 short questions of binary response. A total of 1515 students from 30 intervention schools received the intervention through classroom training based on the school manual and 1778 students of the 30 control schools did not get the manual but a leaflet on climate change and health issues. Six months later, a post-intervention test of the same questionnaire used in the pre-test was performed at both intervention and control schools. The pre and post test scores were analysed along with the demographic data by using random effects model. Results None of the various school level and student level variables were significantly different between the control and intervention group. However, the intervention group had a 17.42% (95% CI: 14.45 to 20.38, P = <0.001) higher score in the post-test after adjusting for pre-test score and other covariates in a multi-level linear regression model. Conclusions These results suggest that school-based intervention for climate change and health adaptation is effective for increasing the knowledge level of school children on this topic.
Virtual Training via Vibrotactile Arrays

What is often missing from many virtual worlds and training simulations is a physical sense of the confinement and constraint of the virtual environment. We present a method for providing localized cutaneous vibratory feedback to the user's right arm. We created a sleeve of tactors linked to a real-time human model; the tactors activate to apply sensation to the corresponding body area. The hypothesis is that vibrotactile feedback to body areas provides the wearer sufficient guidance to assume correct body configurations and ascertain the existence and physical realism of access paths. We present the results of human subject experiments that study both explicit and implicit training of skills using vibrotactile arrays. Implicitly, collision awareness is achieved by activating the appropriate tactor when a body part collides with the scene; thus, the user will attempt to correct his or her body configuration. Explicitly, we use the tactors to guide the body into the proper configuration. The results of human subject experiments clearly show that the use of full arm vibrotactile feedback improves performance over purely visual feedback for navigating the virtual environment, as well as allowing easy acquisition of new skills. These results validate the empirical performance of this concept.