Miracle-dz/UniFAR-FTUs huggingface dataset:
Correlated miR-mRNA Expression Signatures of Mouse Hematopoietic Stem and Progenitor Cell Subsets Predict “Stemness” and “Myeloid” Interaction Networks

Several individual miRNAs (miRs) have been implicated as potent regulators of important processes during normal and malignant hematopoiesis. In addition, many miRs have been shown to fine-tune intricate molecular networks, in concert with other regulatory elements. In order to study hematopoietic networks as a whole, we first created a map of global miR expression during early murine hematopoiesis. Next, we determined the copy number per cell for each miR in each of the examined stem and progenitor cell types. As data is emerging indicating that miRs function robustly mainly when they are expressed above a certain threshold (∼100 copies per cell), our database provides a resource for determining which miRs are expressed at a potentially functional level in each cell type. Finally, we combine our miR expression map with matched mRNA expression data and external prediction algorithms, using a Bayesian modeling approach to create a global landscape of predicted miR-mRNA interactions within each of these hematopoietic stem and progenitor cell subsets. This approach implicates several interaction networks comprising a “stemness” signature in the most primitive hematopoietic stem cell (HSC) populations, as well as “myeloid” patterns associated with two branches of myeloid development.
Shotgun Wounds: A Review of Range and Location as Pertaining to Manner of Death

Shotguns are used in a considerable number of homicides and suicides, and while gunshot wounds are extensively reported in the literature, there is a paucity of shotgun deaths. To specifically study deaths by shotguns, all deaths due to shotguns examined at the Bexar County Medical Examiner's Office between 1988 and 2005 were reviewed. The cases were evaluated by age and sex of the victim, wound location, wound range, and manner of death. Three hundred eighty-seven cases were evaluated, composed of 343 males and 44 females, with 180 homicides, 203 suicides, 3 accidents, and 1 undetermined manner of death. Contact wounds were the most common range in suicides and the head was the most common location. For homicides, the most common range of fire was distant, and the most prevalent distributions of wounds were head, chest, and multiple wound locations. Statistical analysis showed significant differences between homicide and suicide wound locations and ranges, and then odds ratios were generated. Knowledge of the statistical distribution of shotgun wounds in a large series with respect to range of fire and wound location may be of assistance to the medical examiner in evaluating the circumstances of an individual case to arrive at a manner-of-death opinion.
PPARγ2 Gene Pro12Ala and PPARα Gene Leu162Val Single Nucleotide Polymorphisms Interact with Dietary Intake of Fat in Determination of Plasma Lipid Concentrations

Background/Aims: The peroxisome proliferator-activated receptors (PPARs) are transcriptional regulators of lipid metabolism, activated by unsaturated fatty acids. We investigated independent and interactive effects of PPARγ2 gene PPARG Pro12Ala (rs1801282) andPPARαgene PPARA Leu162Val (rs1800206) genotypes with dietary intake of fatty acids on concentrations of plasma lipids in subjects of whom 47.5% had metabolic syndrome. Methods: The RISCK study is a parallel design, randomised controlled trial. Plasma lipids were quantified at baseline after a 4-week high saturated fatty acids diet and after three parallel 24-week interventions with reference (high saturated fatty acids), high monounsaturated fatty acids and low-fat diets. Single nucleotide polymorphisms were genotyped in 466 subjects. Results: At baseline, the PPARG Ala12allele was associated with increased plasma total cholesterol (n = 378; p = 0.04), LDL cholesterol (p = 0.05) and apoB (p =0.05) after adjustment for age, gender and ethnicity. At baseline, PPARA Leu162Val × PPARG Pro12Ala genotype interaction did not significantly influence plasma lipid concentrations. After dietary intervention, gene-gene interaction significantly influenced LDL cholesterol (p =0.0002) and small dense LDL as a proportion of LDL (p = 0.005) after adjustments. Conclusions: Interaction between PPARG Pro12Ala and PPARA Leu162Valgenotypes may influence plasma LDL cholesterol concentration and the proportion as small dense LDL after a high monounsaturated fatty acids diet.
VINS-Mono: A Robust and Versatile Monocular Visual-Inertial State Estimator

One camera and one low-cost inertial measurement unit (IMU) form a monocular visual-inertial system (VINS), which is the minimum sensor suite (in size, weight, and power) for the metric six degrees-of-freedom (DOF) state estimation. In this paper, we present VINS-Mono: a robust and versatile monocular visual-inertial state estimator. Our approach starts with a robust procedure for estimator initialization. A tightly coupled, nonlinear optimization-based method is used to obtain highly accurate visual-inertial odometry by fusing preintegrated IMU measurements and feature observations. A loop detection module, in combination with our tightly coupled formulation, enables relocalization with minimum computation. We additionally perform 4-DOF pose graph optimization to enforce the global consistency. Furthermore, the proposed system can reuse a map by saving and loading it in an efficient way. The current and previous maps can be merged together by the global pose graph optimization. We validate the performance of our system on public datasets and real-world experiments and compare against other state-of-the-art algorithms. We also perform an onboard closed-loop autonomous flight on the microaerial-vehicle platform and port the algorithm to an iOS-based demonstration. We highlight that the proposed work is a reliable, complete, and versatile system that is applicable for different applications that require high accuracy in localization. We open source our implementations for both PCs (https://github.com/HKUST-Aerial-Robotics/VINS-Mono) and iOS mobile devices ( https://github.com/HKUST-Aerial-Robotics/VINS-Mobile).
Left ventricular hemodynamic changes and clinical outcomes after transcatheter atrial septal defect closure in adults.

OBJECTIVES The objectives of this study are to assess current management algorithms for left ventricular (LV) hemodynamic and diastolic changes following atrial septal device occlusion in adult patients. BACKGROUND Percutaneous closure is now routine for atrial septal defects (ASDs). Previous studies show ventricular size normalization following percutaneous closure. Case reports have discussed the incidence of early LV dysfunction following ASD device placement with some recommending delay of closure or placement of a fenestrated device in patients with elevated LV pressures. METHOD All adult patients with an isolated secundum ASD who underwent percutaneous repair were included in this study. In addition to placement of the Amplatzer septal occluder, all patients had a pre and postprocedure transthoracic echocardiography performed measuring myocardial performance index (MPI). Left ventricular end diastolic pressure (LVEDP) was measured before and after balloon occlusion. RESULTS Nineteen patients (17 female and two male) were included in this study. Average age was 47.2 years (± 12.7 years). All defects were of clinical significance with average Qp : Qs = 2.0 (± 0.6). Balloon occlusion led to a significant (P < .01) increase in LVEDP (pre-LVEDP mean = 7.1 mm Hg, post-LVEDP mean = 15.3 mm Hg). There was no significant change in MPI. ASD device size displayed a modest correlation relative to the change in LVEDP (R = 0.42, P = .09). CONCLUSIONS Percutaneous ASD closure induces an increase in LVEDP. Despite this, all patients tolerated device closure without complication. It appears safe to close ASDs in these patients.
Deregulation, Competition and the Race to the Bottom

We exploit the OCC's preemption of national banks from state laws against predatory lending as a quasi-experiment to study the effect of deregulation and its interaction with competition on the supply of complex mortgages (interest-only, negative amortization, and teaser mortgages). Following the preemption ruling, national banks significantly increased their origination of loans with prepayment penalties and negative amortization features by comparison with lenders not regulated by OCC and lenders in states without predatory lending laws. Further, we highlight a competition channel: in counties where OCC-regulated lenders had larger market shares prior to the preemption, even non-OCC lenders responded by increasing their use of these riskier terms to the extent permitted by the state predatory-lending laws. Overall, our evidence suggests that the deregulation of credit markets triggered a "race to the bottom" among distressed financial institutions, working through competition between lenders.
Working “out-of-phase” with reference to chronotype compromises sleep quality in police officers

ABSTRACT The aim of this work was to study the sleep characteristics, blood pressure (BP) and heart rate (HR) of the police officers working during out-of-phase (OP) and in-phase (IP) duty schedules with respect to their chronotypes. Adult male and female police officers (n = 85) were asked to answer Hindi/English version of different questionnaires to assess their chronotype (morningness–eveningness questionnaire; MEQ), PSQI scores (Pittsburgh sleep quality index), daytime sleepiness (Epworth sleepiness scale, ESS) and fatigue levels (fatigue severity scale, FSS) and fill a sleep log. Based on their PSQI scores, the participating subjects (n = 85) were divided into two categories: good sleepers (58/85) and poor sleepers (27/85). Of these 85 subjects, 23 subjects (good sleepers n = 13; poor sleepers n = 10) volunteered for the next part of the study. At the beginning of the study, the existing duty schedule of these subjects was OP and lasted for 4 days (OP1). Thereafter, they were allotted their preferred (IP) duty schedule for 4 days, followed by OP2 for further 4 days. Over the 12-day period, subjects were monitored for their BP and sleep–wake cycle. Results showed that the poor sleepers improved their sleep quality and HR during IP duty schedule; however, good sleepers were not affected significantly.
Sequence-based Typing of Legionella Pneumophila Serogroup 1 Clinical Isolates from Belgium between 2000 and 2010

Sequence-based typing (SBT) is a discriminatory method widely used to genotype Legionella pneu-mophila strains. A total of 86 clinical L. pneumophila serogroup 1 (sg1) isolates, collected between January 2000 and December 2010 in the two Belgian National Reference Centres for Legionella pneumophila, were genotyped using the internationally standardised SBT protocol of the European Working Group for Legionella Infections (EWGLI). The isolates could be classified into 31 different sequence types (ST, index of diversity: 0.879). The obtained STs were submitted to the EWGLI SBT-database for L. pneumophila. In our study, ST47 (27.9%) and ST1 (19.8%) were the most frequently detected STs. The detected profiles were a combination of both frequently isolated and unique STs, and of both worldwide distributed and more local strains. Two STs, ST880 and ST881, were new to the EWGLI database. In conclusion, we characterised L. pneumophila sg1 isolates with the SBT method, and created a Belgian profile database that will be useful for future epidemiological studies.
An ontology for developing e-business models

In this paper we demonstrate why executives and academics should consider thinking about e-business models. We show that the business model concept is an interesting tool for understanding, designing, sharing, measuring, changing and even simulating businesses. Based on an extensive review of e-business and business model literature we develop an e-business model ontology. This ontology defines the concepts in e-business models and the relationships between them and shall be the foundation for a variety of management tools that facilitate business decisions. Our e-business model ontology outlines what value a company offers to which customer segments. It describes the architecture of the firm and its network of partners for creating, marketing and delivering value and relationship capital, in order to generate profitable and sustainable revenue streams.
Primary School Teachers’ Beliefs Relating to Mathematics, Teaching and Assessing Mathematics and Factors that Influence these Beliefs

This study examined primary teachers’ beliefs on teaching, learning and assessing mathematics. In particular, it considered the nature of the beliefs of primary school teachers with regard to mathematics as a subject, and teaching and assessing mathematics. By factor analysis of survey items, it confirmed many theoretical constructs derived from the literature: three major purposes of assessment – to inform the teacher, to inform the learners, and for accountability purposes; two approaches to teaching mathematics – a transmission approach and a constructivist approach; and two views of the nature of mathematics – a static view and a mechanistic view. A third view of mathematics – the dynamic problem-solving view did not form a factor, indicating that this was not a distinct view for the teachers, which is of concern. The study also considered the relationships between these beliefs and specific teacher characteristics, such as gender, years of experience, grade level and qualifications in mathematics. Female teachers scored more highly than male teachers on using assessment to inform the teacher and the learners. The static view of mathematics increased along with grade level, as did the contemporary view of teaching mathematics. The use of assessment to inform the teacher decreased with increasing grade level. There were no clear trends in beliefs with respect to teaching experience or qualifications in mathematics.
BODY MASS INDEX AND ACADEMIC PERFORMANCE OF UNDERGRADUATE UNIVERSITY STUDENTS

Most parents and teachers unscientifically believe that the overweight persons are sluggish, lazy and sleepy; therefore would not do well in Physical and Health Education (PHE) programme at the University. This study investigated the association of Body Mass Index (BMI) and Academic Performance of undergraduate PHE students at the University of Uyo. Actabit BMI calculator and Cumulative Grade Point Average (CGPA) scores were used to collect data from the 90 (30 males and 60 females) undergraduate students for 2011/12 academic session whose ages range from 17 - 28. Descriptive BMI analysis found 8 underweight, 42 normal weights, 11 overweight, 16 pre-obese and 13 obese. On academic performances, 9 were in 2 nd class upper, 47 in 2 nd class lower, 26 in 3 rd class and 8 in pass categories respectively. Multivariate analyses revealed significant differences in BMI and CGPA, no significant association between body mass and academic performance (F (1,89) = . 173; r = . 04, R 2 =. 002; t = . 415. P.69 > . 05) was observed. Therefore no basis to judge a student generally by body mass profile rather conducive learning environment (science and technology) and genetic (typology and mental) endowments would continue to influence academic performance in PHE and Sports Courses.
Normative Indications for Xhosa Speaking Unskilled Workers on the Trail Making and Stroop Tests

The aim of this study was to produce preliminary normative indications for the Trail Making Test and the Stroop Test, administered in English, on a non-clinical sample of Black, Xhosa speaking unskilled workers (N = 33), with an educational level of Grade 11 or Grade 12 from traditionally Black township schools with a relatively disadvantaged quality of education. The sample was equally distributed for sex and level of education, and was divided into two age categories (18–29 and 30–40 years). Within-sample age and gender effects were revealed for the Stroop test only. The younger group performed better than the older group on the Colour Word task, and women performed significantly better than men on the Word task. Normative indications for both measures were descriptively compared to available normative data on westernized populations with relatively advantaged education. The research outcome endorses the need for local norms for use with educationally disadvantaged Xhosa speaking individuals.
[Exfoliation syndrome: clinical study of the irido-corneal angle].

A prospective clinical study of the anterior chamber angle was performed in 263 eyes (152 patients) with pseudoexfoliation syndrome (PSX). No significant difference was found in width and depth of the anterior chamber in comparison with normal population. We found a significative correlation (p less than .0001) between the increase of intraocular pressure (IOP) and the degree of diffuse pigmentation in trabecular meshwork and the Sampaolesi line. When we confronted the two eyes of the same patient, we found that the IOP was greater in the eye with higher pigmentation; and the higher was the difference of pigmentation between the two eyes, the higher was the difference in IOP (p less than .0001). No relation was found between PSX material in angle and IOP. In 24.7% of eyes, we noticed large iris processes, without goniodysgenesis. The results show a significative correlation between the pigmentation of the trabecular meshwork and the IOP.
A patient decision aid regarding antithrombotic therapy for stroke prevention in atrial fibrillation: a randomized controlled trial.

CONTEXT Decision aids are tools designed to help patients participate in the clinical decision-making process. OBJECTIVE To determine whether use of an audiobooklet (AB) decision aid explaining the results of a clinical trial affected the decision-making process of study participants. DESIGN Randomized controlled trial conducted from May 1997 to April 1998. SETTING Fourteen centers that participated in the Stroke Prevention in Atrial Fibrillation (SPAF) III trial. PARTICIPANTS A total of 287 patients from the SPAF III aspirin cohort study, in which patients with atrial fibrillation and a relatively low risk of stroke received 325 mg/d of aspirin and were followed up for a mean of 2 years. INTERVENTION At the end of SPAF III, participants were randomized to be informed of the study results with usual care plus use of an AB (AB group) vs usual care alone (control group). The AB included pertinent information to help patients decide whether to continue taking aspirin or switch to warfarin. MAIN OUTCOME MEASURES Patients' ability to make choices regarding antithrombotic therapy, and 6-month adherence to these decisions. Their knowledge, expectations, decisional conflict (the amount of uncertainty about the course of action to take), and satisfaction with the decision-making process were also measured. RESULTS More patients in the AB group made a choice about antithrombotic therapy than in the control group (99% vs 94%; P = .02). Patients in the AB group were more knowledgeable and had more realistic expectations about the risk of stroke and hemorrhage (in the AB group, 53%-80% correctly estimated different risks; in the control group, 16%-28% gave correct estimates). Decisional conflict and satisfaction were similar for the 2 groups. After 6 months, a similar percentage of patients were still taking their initial choice of antithrombotic therapy (95% vs 93%; P = .44). CONCLUSIONS For patients with atrial fibrillation who had participated in a major clinical trial, the use of an AB decision aid improved their understanding of the benefits and risks associated with different treatment options and helped them make definitive choices about which therapy to take. Further studies are necessary to evaluate the acceptability and impact of decision aids in other clinical settings.
Measurements of relative biological effectiveness of the 70 MeV proton beam at TRIUMF using Chinese hamster V79 cells and the high-precision cell sorter assay.

Measurements of relative biological effectiveness (RBE) have been made on the range-modulated 70 MeV proton beam at TRIUMF using a precise cell sorting survival assay. In this study, Chinese hamster V79-WNRE cells were suspended in medium containing liquid gelatin at 37 degrees C in irradiation tubes and the gel was allowed to solidify by cooling to 4 degrees C. Complete cell survival responses were measured at 11 positions with 2 mm spacing within a proton stopping peak width of approximately 2 cm. Survival responses after proton irradiation were compared with responses to 60Co gamma rays measured at the same time, and RBE values were determined as a function of both dose and depth. Above doses of 4 Gy, the average RBE for these cells throughout the modulated proton stopping distribution was 1.21 +/- 0.05, measured at a survival of 1%. However, we also observed that, within the spread-out Bragg peak, the RBE increased with increasing depth, from approximately 1.2 at the proximal part to > 1.3 at the distal part of the peak. At the distal edge of the stopping distribution, the RBE value increased significantly, to an extent that may be of concern when this region of the treatment volume is close to sensitive tissues. Below 4 Gy, the RBE value was also dependent on radiation dose, increasing significantly to values of approximately 1.37 and 1.56 at 2 and 1 Gy, respectively. Our results illustrate that the use of a single RBE value in different irradiation protocols can be an oversimplification, and argues for the use of "proton gray doses" rather than "gamma-ray equivalent grays. "
Addiction: A Disease of Volition Caused by a Cognitive Impairment

The common etiology of substance and behavioural addictions is one that suggests faulty volition caused by a cognitive impairment. A cognitive impairment that minimizes the recall of the negative effects of the addictive behaviour is viewed as necessary and causal to all addictions. The proposed definition for addiction clarifies the confusion associated with addictive disorders, explains the many variable presentations, and provides an explanation of comorbidity and treatment outcomes. In addition, this paper suggests why this process has not been previously identified.
Sweet love

Terms of endearment such as “sweetie,” “honey,” and “sugar” are commonly used in the context of describing romantic partners. This article explores how a relatively subtle manipulation, namely taste sensations, might influence romantic perceptions of a nonestablished relationship. Consistent with predictions, results from Studies 1 and 2 (n = 280) showed that participants evaluated a hypothetical relationship, but not an existing relationship, more favorably when exposed to sweet taste compared to non-sweet taste control. Study 3 (n = 142) further showed that participants indicated greater interest in initiating a relationship with a potential partner when exposed to sweet taste, as compared to control participants. Implications for the role of sweet taste experiences in attraction and relationship initiation are discussed.
4-Aminobenzoic acid 4-methylpyridine/4-methylpyridinium 4-aminobenzoate 0.58/0.42: a redetermination from the original data

The title structure, 4-aminobenzoic acid 4-methylpyridine/4-methylpyridinium 4-aminobenzoate 0.58/0.42, has been redetermined from the data published by Kumar et al. (2015). Acta Cryst. E71, o125-o126. The motivation for this redetermination follows from negligence of important features of the difference electron-density maps as well as from wrongly applied constraints, which significantly affect the structural model. The corrections affect mainly the positions of the H atoms involved in the hydrogen bonds (centered on the primary amine group for which the H atom turned out to be disordered over two positions about the centre of an N⋯H⋯O hydrogen bond) and the methyl group, which is disordered and has now been remodelled.