Miracle-dz/UniFAR-FTUs huggingface dataset:
Emily Dickinson and the Discourse of Intimacy

Emily Dickinson is unique among major poets for being both very obscure and very popular, not only among academics but in the world at large. But although critics for more than a century have described their various responses to the seemingly paradoxical impression of obscurity and popularity, they have not explained it. Dickinson is, I believe, popular because she creates a sense of intimacy in which she iconically represents a crucial fact about intimate conversation: the closer the relationship between participants in a discourse, the more implicit the speaker’s discourse becomes and the less help the hearer needs to process it. Precisely this contrary to fact intimacy between persona and reader accounts for the 'difficulty' of a Dickinson poem, difficult because it leaves to silence what formal discourse among strangers normally would demand. This very same intimacy accounts for the closeness and strong sense of identification that Dickinson’s readers feel, even though they sometimes find it difficult to explain exactly what a poem might be saying. Dickinson is remarkable precisely because she is able through silence to capture the essence of true intimacy that gives her poetry its power. She draws the reader into a feeling of intimacy by adopting strategies of language that can be explained through a number of cognitive principles of discourse. The five principles I discuss in this paper all share the iconic feature that relates linguistic 'lesion' with responsive 'intimacy. '
Autonomous phagosomal degradation and antigen presentation in dendritic cells

Phagocytosis plays a critical role in both innate and adaptive immunity. Phagosomal fusion with late endosomes and lysosomes enhances proteolysis, causing degradation of the phagocytic content. Increased degradation participates in both innate protection against pathogens and the production of antigenic peptides for presentation to T lymphocytes during adaptive immune responses. Specific ligands present in the phagosomal cargo influence the rate of phagosome fusion with lysosomes, thereby modulating both antigen degradation and presentation. Using a combination of cell sorting techniques and single phagosome flow cytometry-based analysis, we found that opsonization with IgG accelerates antigen degradation within individual IgG-containing phagosomes, but not in other phagosomes present in the same cell and devoid of IgG. Likewise, IgG opsonization enhances antigen presentation to CD4+ T lymphocytes only when antigen and IgG are present within the same phagosome, whereas cells containing phagosomes with either antigen or IgG alone failed to present antigen efficiently. Therefore, individual phagosomes behave autonomously, in terms of both cargo degradation and antigen presentation to CD4+ T cells. Phagosomal autonomy could serve as a basis for the intracellular discrimination between self and nonself antigens, resulting in the preferential presentation of peptides derived from opsonized, nonself antigens.
A Path Analysis of the Behavioral Intention of Secondary Teachers to Integrate Technology in Private Schools in Florida

This research was designed to investigate the behavioral intention of a sample of teachers to develop curriculum based projects that require students to use technology. This research employed a quantitative study design of an educational version of the Universal Theory of Acceptance and Use of Technology model. The UTAUT model was expanded to include factors from the Theory of Planned Behavior, and Social Cognitive Theory. The sample was composed of 251 private school teachers in Florida who completed an on-line survey instrument based upon the UTAUT model. The results were analyzed with confirmatory factor analysis that identified several factors that contributed to the behavioral intention of the teachers to integrate technology. In the final factor analysis, Social Influences, Effort Expectancy, and Anxiety all proved to be very strong factors. Attitude, Performance Expectancy, and Facilitating Conditions were moderate to strong factors in this final analysis. The relationships between the identified factors were determined through the development of a path model using partial least squares analysis. The constructs having the strongest relationship with Behavioral Intention, and hence, having a stronger effect were Attitude (β=.775, p < .001), Performance Expectancy (β=.698, p < .001), and Effort Expectancy (β=.667, p < .001). The structural model also supported that Behavioral Intention is strongly related to actual Use (β=.561, p < .001). The construct of Facilitating Conditions had a weak and negative relationship with Use (β=.-131, p =.16).
Reconfigurable finite-state machine based IP lookup engine for high-speed router

Internet protocol (IP) address lookup is one of the major performance bottlenecks in high-end routers. This paper presents an architecture for an IP address lookup engine based on programmable finite-state machines (FSMs). The IP address lookup problem can be translated into the implementation of a large FSM. Our hardware engine is then used to implement this FSM using a structured approach, in which the large FSM is broken down into a set of smaller FSMs which are then mapped into reconfigurable hardware blocks. The design of our hardware engine is based on a regular and well structured architecture, which is easy to scale. Our simulation results demonstrate that the FSM based architecture can easily scale to wire speed performance at OC-192 rates. Unlike previous approaches, the performance of our architecture is not constrained by memory bandwidth and is, therefore, in principle scalable with very large scale integration technology.
Experiencias perceptuales inusuales, experiencias anómalo/paranormales y propensión a la esquizotipia

There seems to be similarities between schizotypal personality and paranormal experiences, in fact, some of the symptoms of PTSD in DSM- match a number of anomalous/paranormal experiences. Positive schizotypy, including magical thinking, hallucinations and other unusual perceptual experiences, has also been associated with paranormal experiences and beliefs. However, paranormal experiences differ from psychotic experiences in nonclinical populations. In order to establish differences between positive and negative symptoms of schizotypy, we compared a group of believers in the paranormal (N= 121) and a sample of undergraduate students (N= 588). The hypothesis that believers would have higher scores in Schizotypy positive symptoms was confirmed. There was a significant difference in positive symptoms of schizotypy among the group of students with and no experiences, although not significant for negative symptoms
The Tomato Aux/IAA Transcription Factor IAA9 Is Involved in Fruit Development and Leaf Morphogenesisw⃞

Auxin/indole-3-acetic acid (Aux/IAA) proteins are transcriptional regulators that mediate many aspects of plant responses to auxin. While functions of most Aux/IAAs have been defined mainly by gain-of-function mutant alleles in Arabidopsis thaliana, phenotypes associated with loss-of-function mutations have been scarce and subtle. We report here that the downregulation of IAA9, a tomato (Solanum lycopersicum) gene from a distinct subfamily of Aux/IAA genes, results in a pleiotropic phenotype, consistent with its ubiquitous expression pattern. IAA9-inhibited lines have simple leaves instead of wild-type compound leaves, and fruit development is triggered before fertilization, giving rise to parthenocarpy. This indicates that IAA9 is a key mediator of leaf morphogenesis and fruit set. In addition, antisense plants displayed auxin-related growth alterations, including enhanced hypocotyl/stem elongation, increased leaf vascularization, and reduced apical dominance. Auxin dose–response assays revealed that IAA9 downregulated lines were hypersensitive to auxin, although the only early auxin-responsive gene that was found to be upregulated in the antisense lines was IAA3. The activity of the IAA3 promoter was stimulated in the IAA9 antisense genetic background, indicating that IAA9 acts in planta as a transcriptional repressor of auxin signaling. While no mutation in any member of subfamily IV has been reported to date, the phenotypes associated with the downregulation of IAA9 reveal distinct and novel roles for members of the Aux/IAA gene family.
The Swedish Sex Purchase Act: Claimed Success and Documented Effect

Sweden's criminalization of the purchase of sexual services in 1999 is said to be a unique measure: to only punish those who buy sexual services, not those who sell them. However this alleged uniqueness is questionable, and for several reasons. There are a number of other laws and regulations against prostitution, which effectively make Swedish prostitution policy similar to those countries in the world that attempt to reduce or eradicate prostitution with legislative means. Another reason the claim to uniqueness is doubtful is that one must examine more than the wording of a law or policy model ("it is only those who buy sex who are being punished") when analyzing it – one has to consider the actual consequences. For instance, a law against the purchase of the services offered in massage therapy, psychotherapy or sexual health counselling would obviously not only punish the buyers, but also carry negative consequences for those who offer the services. Therefore, to only focus on one of several prostitution laws, ignore its consequences and call this a "unique" policy model is either ignorant or a deliberate deception.
ARE NECTAR ROBBERS CHEATERS OR MUTUALISTS

Nectar robbers are birds, insects, or other flower visitors that remove nectar from flowers through a hole pierced or bitten in the corolla. This paper is a review of the effects of nectar robbers on pollinators, pollination, and fitness of the plants they rob. Charles Darwin assumed that nectar robbers had a negative impact on the plants that they visit, but research done in the last 50 years indicates that they often have a beneficial or neutral effect. Several studies document that robbers frequently pollinate the plants that they visit. Robbers may also have an indirect effect on the behavior of the legitimate pollinators, and in some circumstances, the change in pollinator behavior could result in improved fitness through increased pollen flow and outcrossing. The effects of nectar robbers are complex and depend, in part, on the identity of the robber, the identity of the legitimate pollinator, how much nectar the robbers remove, and the variety of floral resources available in the environment.
Isolation of exosomes from whole blood by integrating acoustics and microfluidics

Significance We have developed a unique, integrated, on-chip technology that is capable of isolating exosomes or other types of extracellular vesicles, directly from undiluted whole-blood samples in an automated fashion. Automated exosome isolation enables biohazard containment, short processing time, reproducible results with little human intervention, and convenient integration with downstream exosome analysis units. Our method of integrating acoustics and microfluidics leads to the isolation of exosomes with high purity and yield. With its label-free, contact-free, and biocompatible nature, it offers the potential to preserve the structures, characteristics, and functions of isolated exosomes. This automated, point-of-care device can further help in advancing exosome-related biomedical research with potential applications in health monitoring, disease diagnostics, and therapeutics. Exosomes are nanoscale extracellular vesicles that play an important role in many biological processes, including intercellular communications, antigen presentation, and the transport of proteins, RNA, and other molecules. Recently there has been significant interest in exosome-related fundamental research, seeking new exosome-based biomarkers for health monitoring and disease diagnoses. Here, we report a separation method based on acoustofluidics (i.e., the integration of acoustics and microfluidics) to isolate exosomes directly from whole blood in a label-free and contact-free manner. This acoustofluidic platform consists of two modules: a microscale cell-removal module that first removes larger blood components, followed by extracellular vesicle subgroup separation in the exosome-isolation module. In the cell-removal module, we demonstrate the isolation of 110-nm particles from a mixture of micro- and nanosized particles with a yield greater than 99%. In the exosome-isolation module, we isolate exosomes from an extracellular vesicle mixture with a purity of 98.4%. Integrating the two acoustofluidic modules onto a single chip, we isolated exosomes from whole blood with a blood cell removal rate of over 99.999%. With its ability to perform rapid, biocompatible, label-free, contact-free, and continuous-flow exosome isolation, the integrated acoustofluidic device offers a unique approach to investigate the role of exosomes in the onset and progression of human diseases with potential applications in health monitoring, medical diagnosis, targeted drug delivery, and personalized medicine.
Elongation factors are involved in cytokinesis of sea urchin eggs

Cleavage furrows (CFs) have been isolated from dividing sea urchin eggs and the protein constituents have been analyzed by two‐dimensional gel electrophoresis ( Fujimoto & Mabuchi, J. Biochem. 122, 518–524, 1997 ). Two proteins of 51 and 32 kDa, respectively, have been found to be enriched in the CF preparation. Here, we show that these proteins are identical to the protein elongation factor 1α (EF‐1α) and 1β (EF‐1β), respectively. Furthermore, the CF 51‐kDa protein is identical to the 51‐kDa protein which had been isolated as a component of the microtubule organizing granules of mitotic sea urchin eggs. The 51‐kDa protein bundles F‐actin in vitro. This activity is suppressed by Ca2+/calmodulin or GTPγS. The 32‐kDa protein binds EF‐1α both in vitro and in cell extract, and is shown to suppress the F‐actin‐bundling activity of the 51‐kDa protein. Microinjection of a monoclonal antibody against the 51‐kDa protein or that of His‐tagged 32‐kDa protein into dividing sea urchin eggs at the onset of cleavage leads to failure of cytokinesis. These results strongly suggest that EF‐1α is involved in maintenance of the structure of the contractile ring and EF‐1β regulates the F‐actin‐bundling activity of EF‐1α.
A treatise on language methods and language-games in autism

Although it is generally understood that autism is a developmental disability affecting social learning, my social constructionist perspective suggested to me that, strangely, current theories aimed at explaining the nature of autism appeared not to fully reflect the essential social aspects of autism. Given that typically developing human beings become fully socialised through learning a first language, it appeared to me that autism research has, especially of late, failed to give sufficient attention to language despite Kanner’s advice. In researching this thesis I have sought to make a contribution to knowledge of my subject by: (1) developing a synthesis of current knowledge of autistic language methods as a practical framework to guide future research focused on language in autism; (2) critiquing ‘established’ autism theory; (3) drawing attention to Ludwig Wittgenstein’s neglected contributions to the philosophy of mind; and (4) reviewing the contribution of ‘alternative’ theory, including Wittgenstein’s criteriological theory, to an understanding of autism. My research has involved reviewing: (a) the literature on autistic language methods; (b)Conversation Analysis of autistic conversation; (c) narrative writing by authors diagnosed or retrospectively diagnosed with autism; and (d) existing autism theory. I conclude that there are specific features of talk and writing that reflect autism with some features of autistic writing being a ‘mirror image’ of features of autistic talk. A further, important, conclusion is that there are strengths as well as weaknesses associated with autistic talk and writing i.e., from a linguistic stance, it is wrong to regard autism as a disability; rather, it involves a different way of communicating – both verbally and in writing – than is seen in typically developing people. I also conclude that alternative theory has much to contribute to an understanding of autism, and that the atypical nature of autistic social development results in autistic people failing to fully come to terms with language-games.
The Economic and Demographic Transition, Mortality, and Comparative Development

We propose a unified growth theory to investigate the mechanics generating the economic and demographic transition, and the role of mortality differences for comparative development. The framework can replicate the quantitative patterns in historical time series data and in contemporaneous cross-country panel data, including the bi-modal distribution of the endogenous variables across countries. The results suggest that differences in extrinsic mortality might explain a substantial part of the observed differences in the timing of the take-off across countries and the worldwide density distribution of the main variables of interest.
Functional Regulatory T Cells Are Collected in Stem Cell Autografts by Mobilization with High-Dose Cyclophosphamide and Granulocyte Colony-Stimulating Factor1

High-dose cyclophosphamide (Cy) and G-CSF are widely used to mobilize hemopoietic stem cells for treating patients with high-dose chemotherapy and autologous stem cell transplantation (ASCT). Because lymphocyte count in the graft collected after Cy-G-CSF treatment is an independent survival factor after ASCT for patients with multiple myeloma, our purpose was to study how Cy-G-CSF treatment affects the phenotype and function of T cells in patients with multiple myeloma. Cy induced a 3-fold decrease of T cell counts with a slow and partial T cell recovery of one-third at the time of hemopoietic stem cell collection. Cy-G-CSF treatment did not affect the relative ratios of central memory, effector memory, and late effector CD4+ or CD8+ T cells, but a decrease in the percentage of naive CD4+ cells was observed. The percentages of CD25+ cells increased 2- to 3-fold in CD4+ and CD8+ T cells, the former including both activated CD25low and CD25high cells. CD4+CD25high cells were regulatory T cells (Treg) that expressed high levels of FOXP3, CTLA-4, and GITR and displayed in vitro suppressive properties. The recovery of Treg absolute counts after Cy-G-CSF treatment was higher than the recovery of other lymphocyte subpopulations. In conclusion, Cy-G-CSF treatment induces a severe T cell count decrease without deleting Treg, which are potent inhibitors of antitumor response. The present data encourage novel therapeutic strategies to improve T cell recovery following ASCT while limiting Treg expansion.
Analysis of the recombination event generating a vesicular stomatitis virus deletion defective interfering particle

cDNA clones of different portions of the L cistron and 5'-terminal region of the vesicular stomatitis virus genome have been prepared and used to identify the exact site of the deletion in the defective interfering particle, DI-LT. The deletion extends from nucleotide 251 from the beginning of the L gene to a position 342 nucleotides from the end of the genome. The nucleotide sequences flanking the deletion site, as well as those at the ends of the deleted segment, did not contain any obvious vesicular stomatitis virus initiation or termination signals as had been found near the recombination sites in other defective interfering particle RNAs. The results best fit a model for the origin of this type of defective interfering particle in which the polymerase interrupts its synthesis and moves with its nascent daughter strand to a new position on the template and resumes synthesis there, further extending the nascent strand. Neither the interruption nor the resumption of synthesis appears to be in response to the template nucleotide sequence. The sequences of two partial L cistron clones also reveal open reading frames that code for amino acid sequences likely to be the amino and carboxy termini of the L protein.
Structural Organization of the 19S Proteasome Lid: Insights from MS of Intact Complexes

The 26S proteasome contains a 19S regulatory particle that selects and unfolds ubiquitinated substrates for degradation in the 20S catalytic particle. To date there are no high-resolution structures of the 19S assembly, nor of the lid or base subcomplexes that constitute the 19S. Mass spectra of the intact lid complex from Saccharomyces cerevisiae show that eight of the nine subunits are present stoichiometrically and that a stable tetrameric subcomplex forms in solution. Application of tandem mass spectrometry to the intact lid complex reveals the subunit architecture, while the coupling of a cross-linking approach identifies further interaction partners. Taking together our results with previous analyses we are able to construct a comprehensive interaction map. In summary, our findings allow us to identify a scaffold for the assembly of the particle and to propose a regulatory mechanism that prevents exposure of the active site until assembly is complete. More generally, the results highlight the potential of mass spectrometry to add crucial insight into the structural organization of an endogenous, wild-type complex.
CFD of Oscillating Airfoil Pitch Cycle by using PISO Algorithm

This research paper presents the CFD analysis of oscillating airfoil during pitch cycle. Unsteady subsonic flow is simulated for pitching airfoil at Mach number 0.283 and Reynolds number 3.45 millions. Turbulent effects are also considered for this study by using K-ω SST turbulent model. Two-dimensional unsteady compressible Navier-Stokes code including two-equation turbulence model and PISO pressure velocity coupling is used. Pressure based implicit solver with first order implicit unsteady formulation is used. The simulated pitch cycle results are compared with the available experimental data. The results have a good agreement with the experimental data. Aerodynamic characteristics during pitch cycles have been studied and validated. Keywords—Angle of attack, Centre of pressure, subsonic flow, pitching moment coefficient, turbulence mode
System theoretic perspectives of the sampling theorem

In this paper we study the (classical) problem of reconstructing a continuous-time signal from its samples. We adopt a system-theoretical viewpoint of this problem. Namely, we assume that the continuous-time signal is modeled as the output of a linear time-invariant system and then formulate the reconstruction problem as the (either $L^2$ or $L^\infty$) optimal model-matching problem in the lifted domain. This leads to an alternative proof of the celebrated Sampling Theorem and some interesting extensions.
The Psychology of Closed Mindedness

Preface. Introduction. Motivational Bases of Closed and Open Mindedness. Specific Manifestations of Closure Needs in Information Processing Activities. Prior Psychological Analyses of Closed and Open Mindedness. Intrapersonal Effects of Closure Needs. Interpersonal Consequences of the Closure Motivation. Group Phenomena. Need for Closure Impact on Inter-Group Processes. Need for Closure in Real World Contexts. References.