Miracle-dz/UniFAR-FTUs huggingface dataset:
Dietary PUFA Intervention Affects Fatty Acid- and Micronutrient Profiles of Beef and Related Beef Products

The study investigated the dietary impact of 18:3n-3 vs. 18:2n-6 on fatty acid- and micronutrient concentration of beef muscle and the extent of diet- and processing-induced changes of lipid- and micronutrient concentrations of beef products made thereof (German Corned beef (GCB), tea sausage spread (TSS), scalded sausage (SS)). Beef and beef products were obtained from German Holstein bulls which either received a control diet consisting of maize silage and concentrate with soybean meal (41%), or an experimental diet of grass silage and concentrate plus rapeseed cake (12%) and linseed oil (3%). The study revealed that upon an 18:3n-3 vs. 18:2n-6 intervention the amounts of 18:3n-3, EPA and Σn-3 LC-PUFA were significantly increased by 2.6, 2.3 and 1.7 fold, respectively. Experimental diet significantly increased β-carotene contents, and the γ-tocopherol contents were decreased. During beef processing, n-3 PUFA from beef were found to be product-specifically transferred into the corresponding beef products. 18:3n-3 and Σn-3 LC-PUFA contents were found to be 1.4 and 1.5 times higher in GCB from grass silage- than maize silage-fed bulls. The trace element contents in GCB (iron, copper, zinc, selenium) were not affected by the diet; however γ-tocopherol contents were decreased by experimental diet. In conclusion, dietary n-3 PUFA were completely transferred into beef products unaffected by beef processing conditions.
The Zettabyte File System

In this paper we describe a new file system that provides strong data integrity guarantees, simple administration, and immense capacity. We show that with a few changes to the traditional high-level file system architecture — including a redesign of the interface between the file system and volume manager, pooled storage, a transactional copy-onwrite model, and self-validating checksums — we can eliminate many drawbacks of traditional file systems. We describe a general-purpose productionquality file system based on our new architecture, the Zettabyte File System (ZFS). Our new architecture reduces implementation complexity, allows new performance improvements, and provides several useful new features almost as a side effect.
Distributed Stochastic ADMM for Matrix Factorization

Matrix factorization (MF) has become the most popular technique for recommender systems due to its promising performance. Recently, distributed (parallel) MF models have received much attention from researchers of big data community. In this paper, we propose a novel model, called distributed stochastic alternating direction methods of multipliers (DS-ADMM), for large-scale MF problems. DS-ADMM is a distributed stochastic variant of ADMM. In particular, we first devise a new data split strategy to make the distributed MF problem fit for the ADMM framework. Then, a stochastic ADMM scheme is designed for learning. Finally, we implement DS-ADMM based on message passing interface (MPI), which can run on clusters with multiple machines (nodes). Experiments on several data sets from recommendation applications show that our DS-ADMM model can outperform other state-of-the-art distributed MF models in terms of both efficiency and accuracy.
ANALISIS EKONOMI KEBIJAKAN DANA DESA TERHADAP KEMISKINAN DESA DI KABUPATEN TULUNGAGUNG TAHUN 2015-2016

Penelitian dengan judul Â“Analisis Ekonomi Kebijakan Dana Desa Terhadap Kemiskinan Desa di Kabupaten TulungagungÂ”. (Intan Mala Sari, Dr. Aris Soelistyo, M.Si., Drs. M Faisal Abdullah, M.M.) Tujuan dari penelitian ini untuk menganalisis perbedaan kemiskinan desa di Kabupaten Tulungagung antara Tahun 2015 dengan 2016 dan untuk menganalisis pengaruh Dana Desa dan ADD terhadap kemiskinan desa di Kabupaten Tulungagung tahun 2015-2016. Alat analisis yang digunakan adalah regresi berganda dengan data panel yang kemudian dilakukan pengujian hipotesis dengan uji F, uji t, dan Koefisien Determinasi (R^2) pada tingkat kesalahan α=5%. Hasil analisis regresi data panel dengan model terpilih adalah Fixed Effect Model menunjukkan bahwa terjadi perbedaan kemiskinan desa di Kabupaten Tulungagung antara tahun 2015 dengan 2016, variabel yang digunakan dalam model yaitu Dana Desa dan ADD berpengaruh terhadap kemiskinan desa dengan nilai masing-masing −4,52 untuk Dana Desa dan −1,52 untuk ADD. Sedangkan nilai koefisien determinasi (R^2) adalah 0,99 atau 99%, ini menunjukkan bahwa kemampuan variabel Dana Desa dan ADD dalam menjelaskan kemiskinan desa adalah sebesar 99%.
A Hybrid GRASPxVNS Algorithm with Effective Depot Reduction Mechanism for the Capacitated Location Routing Problem

In this paper, we propose a new hybrid heuristic to solve the Location Routing Problem with capacitated depots and capacitated vehicles. The heuristic combines a Greedy Randomized Adaptive Search Procedure to determine the depot locations to be established and a Variable Neighborhood Search to optimize the vehicle routes originating at the opened depots. Furthermore, we enhance the heuristic by a powerful depot reduction mechanism. In numerical studies performed on the benchmark sets available from the literature, our GRASPxVNS heuristic outperforms all state-of-the-art heuristics in terms of solution quality and computing time. In addition, our algorithm is able to find 22 new best solutions on the large instance sets. Technical Report 01/2011 IT-based Logistics, Goethe University Frankfurt
High Producer Haplotype (CAG) of -863C/A, -308G/A and -238G/A Polymorphisms in the Promoter Region of TNF-α Gene Associate with Enhanced Apoptosis of Lymphocytes in HIV-1 Subtype C Infected Individuals from North India

Introduction The natural history of HIV-1 infection and its progression towards AIDS vary considerably among individuals. Host genetic factors may be one of the possible reasons for variable HIV-1 disease progression. Single nucleotide polymorphisms (SNPs) in the promoter region of TNF-α gene can influence its production. The aim of the present study was to determine the association of functional TNF-α SNPs and its associated parameters related to apoptosis that may influence the rate of HIV-1 disease progression. Methods Therapy naive, 100 HIV slow progressors (SPs), 100 HIV fast progressors (FPs), 50 HIV exposed but seronegative individuals (ESNs) and 260 healthy controls from same ethnic origin were recruited. Genotyping of TNF-α variants (−863C/A, -308G/A and -238G/A) was done using PCR-RFLP. CD4 counts were determined by flow cytometry. Plasma viral load was estimated by COBAS AMPLICOR HIV-1 monitor test. Plasma TNF-α concentration was estimated by Human CBA Th1/Th2 cytokine kit. The lymphocyte mitochondrial membrane potential was measured by JC-1 dye by flow cytometry. Results Genotype and allele frequency of TNF-α -238G/A and -863C/A was not significantly different in HIV-1-infected patients when compared to controls, while that of TNF-α -308G/A variant (high TNF-α producer) was significantly higher in FPs compared to SPs (p<0.01, OR = 3.43). Haplotype analyses also showed that carriers of high TNF-α producing haplotype CAG was significantly more common among FPs compared to SPs (p<0.01, OR = 3). The circulating TNF-α levels in blood also correlated well with genotypes. The lymphocyte mitochondrial membrane potential of FPs having CAG haplotype was significantly low as compared to wild type (CGG) haplotype (417±22 vs 571±28, p<0.01). Conclusion High producer haplotype, CAG of TNF-α gene associates with enhanced apoptosis of lymphocytes in HIV-1 infected individuals, hence faster progression to AIDS. However, further functional studies are needed to confirm this association and this knowledge may help clinicians to better understand the disease outcome.
Indefinite Detention, Colonialism, and Settler Prerogative in the United States

The primacy accorded individual civil and political rights is often touted as one of the United States’ greatest achievements. However, mass incarcerations of indefinite duration have occurred consistently throughout US history and have primarily targeted people of color. The dominant narrative insists that the United States is a political democracy and portrays each instance of indefinite detention in exceptionalist terms. This essay argues that the historical patterns of indefinite detention are better explained by recognizing the United States as a settler colonial state whose claimed prerogative to expand its territorial reach and contain/control populations over which it exercises jurisdiction has inevitably resulted in the involuntary inclusion and concomitant exclusion of peoples of color.
The influence of fashion involvement, hedonic consumption, and visual merchandising on impulse buying with positive emotion as mediation variables

This research aims to analyze the influence of fashion involvement, hedonic consumptions, and virtual merchandising on impulse buying with positive emotion as mediator variable at Popies Girls Shop. The population of this study was the female students of Economics and Business Faculty, Jenderal Soedirman University. The researcher used 145 samples. Sampling technique used in this research was random sampling. Data were analyzed using Structural Equation Modeling (SEM). The result of this research analysis shows that: (1) the involvement of fashion had a positive effect on positive emotion, (2) the trend of hedonic consumption did not have effect on positive emotion, (3) visual merchandising had positive effect on positive emotion, (4) positive emotion had positive effect on impulse buying, (5) positive emotion mediates the relationship between involvement fashion and impulse buying, (6) positive emotion does not mediate the relationship between trends in hedonic consumption and impulse buying, (7) positive emotion mediates the relationship between the visual merchandising and impulse buying.
Global asymptotic behaviour of aquatic vegetation in a periodical mediated system

In this paper, we consider a competition model between two species in an aquatic system. The operating parameters and the species specific response functions are periodic functions of time. Species-specific removal rates are also permitted to be periodic. A threshold result on the global dynamics of the scalar asymptotically periodic Kolmogorov equation is applied to a growth model of two species. Sufficient conditions ensure uniform persistence of all the species and guarantee that the full system admits at least one positive, periodic solution. The qualitative behaviour of this model is determined analytically and numerically. ii S t S t S t D t c P t S t x t x t P t S t D t x t S S x x i           
The Dynamics of Bargaining Postures: The Role of a Third Party

In many real world negotiations, from wage contract bargaining to product liability disputes, the bargaining parties often interact repeatedly and have the option of seeking outside judgement. This paper studies a model of repeated bargaining with a third party to analyze how and why bargaining postures endogenously evolve over time. A privately informed long-lived player bargains with a sequence of short-lived players, one at a time. Should the players fail to reach an agreement, an unbiased yet imperfect third party is called upon to make a judgement. The uninformed short-lived players learn through two channels: observed behavior of the informed player (\soft" information) and, if any, verdicts of the third party (\hard" information). The long-lived player wants to guard his private information by bargaining tough but at the expense of more information disclosure from the third party. As a result of the strategic use of these two sources of information, the players' bargaining postures change as the uninformed players' beliefs evolve. Interestingly, as third party information becomes more precise, the players adopt tough bargaining postures for a wider range of beliefs. Many repeated bargaining problems can be analyzed in this framework. In particular, the equilibrium dynamics provide an explanation for the puzzling contrast between the bargaining postures of Merck and Pfizer in their recent high-profile product liability litigations. The results also help us understand several other phenomena documented in the related literature.
Positivity and canonical bases in rank 2 cluster algebras of finite and affine types

The main motivation for the study of cluster algebras initiated in math.RT/0104151, math.RA/0208229 and math.RT/0305434 was to design an algebraic framework for understanding total positivity and canonical bases in semisimple algebraic groups. In this paper, we introduce and explicitly construct the canonical basis for a special family of cluster algebras of rank 2.
Epidemiological aspects of obsessive-compulsive disorder in community adolescents and young adults: subsequent psychopathology and risk factors

Obsessive-compulsive disorder (OCD) is associated with severe interference in social and occupational functioning, quality of life, and substantial comorbidity. Improved knowledge of risk factors for OCD and pathways to subsequent mental disorders could set the stage for successfully preventing OCD and the progression of psychopathology. Thus, the aim of this thesis was to examine (1) whether OCD predicts the subsequent onset of various mental disorders and (2) whether certain risk factors, that is, behavioral inhibition (BI), parental rearing, and adverse life events and the interaction thereof, are associated with an increased risk of OCD. A representative community sample of 3,021 adolescents and young adults was prospectively followed for up to 10 years. DSM-IV OCD, other mental disorders, and adverse life events were assessed using the DIA-X/M-CIDI. Parental rearing and BI (social and nonsocial fear components) were assessed with self-report questionnaires. OCD was associated with the subsequent onset of social phobia, generalized anxiety disorder (GAD), bipolar disorder (BIP), dysthymia, and bulimia nervosa. Total BI, both its components, and paternal rejection were found to increase the risk of OCD. Components of BI moderated the effect of adverse life events and paternal rearing on OCD. Maternal and paternal emotional warmth moderated the association between adverse life events and OCD. The findings indicate that interventions for individuals with OCD are important to prevent the subsequent onset of internalizing disorders. Further research is required to fully understand the underlying mechanisms. Knowledge of the demonstrated risk factors and moderators might inform future prevention efforts for OCD. Results emphasize the need to investigate (1) whether early treatment of OCD reduces the risk of subsequent psychopathology and (2) the effectiveness of prevention programs that target individuals at high risk of OCD.
OUTRIDER: Efficient memory latency tolerance with decoupled strands

We present Outrider, an architecture for throughput-oriented processors that provides memory latency tolerance to improve performance on highly threaded workloads. Out-rider enables a single thread of execution to be presented to the architecture as multiple decoupled instruction streams that separate memory-accessing and memory-consuming instructions. The key insight is that by decoupling the instruction streams, the processor pipeline can tolerate memory latency in a way similar to out-of-order designs while relying on a low-complexity in-order micro-architecture. Moreover, instead of adding more threads as is done in modern GPUs, Outrider can tolerate memory latency with fewer threads and reduced contention for resources shared amongst threads. We demonstrate that Outrider can outperform single threaded cores by 23-131% and a 4-way simultaneous multithreaded core by up to 87% on data parallel applications in a 1024-core system. Moreover, Outrider achieves these performance gains without incurring the overhead of additional hardware thread contexts, which results in improved area efficiency compared to a multithreaded core.
The physics behind the larger scale organization of DNA in eukaryotes

In this paper, we discuss in detail the organization of chromatin during a cell cycle at several levels. We show that current experimental data on large-scale chromatin organization have not yet reached the level of precision to allow for detailed modeling. We speculate in some detail about the possible physics underlying the larger scale chromatin organization.
Ubpy controls the stability of the ESCRT-0 subunit Hrs in development

Ubiquitylated developmental membrane signaling proteins are often internalized for endocytic trafficking, through which endosomal sorting complexes required for transport (ESCRT) act sequentially to deliver internalized cargos to lysosomes. The ESCRT function in endocytic sorting is well established; however, it is not fully understood how the sorting machinery itself is regulated. Here, we show that Ubiquitin isopeptidase Y (Ubpy) plays a conserved role in vivo in the homeostasis of an essential ESCRT-0 complex component Hrs. We find that, in the absence of Drosophila Ubpy, multiple membrane proteins that are essential components of important signaling pathways accumulate in enlarged, aberrant endosomes. We further demonstrate that this phenotype results from endocytic pathway defects. We provide evidence that Ubpy interacts with and deubiquitylates Hrs. In Ubpy-null cells, Hrs becomes ubiquitylated and degraded in lysosomes, thus disrupting the integrity of ESCRT sorting machinery. Lastly, we find that signaling proteins are enriched in enlarged endosomes when Hrs activity is abolished. Together, our data support a model in which Ubpy plays a dual role in both cargo deubiquitylation and the ESCRT-0 stability during development.
Cardiac Septal and Valvular Dysmorphogenesis in Mice Heterozygous for Mutations in the Homeobox Gene Nkx2-5

Heterozygous mutations in the cardiac homeobox gene, NKX2-5, underlie familial cases of atrial septal defect (ASD) with severe atrioventricular conduction block. In this study, mice heterozygous for Nkx2-5–null alleles were assessed for analogous defects. Although ASD occurred only rarely, atrial septal dysmorphogenesis was evident as increased frequencies of patent foramen ovale and septal aneurysm, and decreased length of the septum primum flap valve. These parameters were compounded by genetic background effects, and in the 129/Sv strain, septal dysmorphogenesis bordered on ASD in 17% of Nkx2-5 heterozygotes. In a proportion of neonatal heterozygotes, as well as in adults with ASD, we found that the size of the foramen ovale was significantly enlarged and altered in shape, potentially exposing the normally thin septum primum to excessive hemodynamic forces. Therefore, defective morphogenesis of the septum secundum may be one contributing factor in the generation of patent foramen ovale, septal aneurysm, and certain ASDs. Mild prolongation of P-R interval in females and an increased frequency of stenotic bicuspid aortic valves were also features of the Nkx2-5 heterozygous phenotype. Our data demonstrate that the complex effects of Nkx2-5 haploinsufficiency in mice are weaker but convergent with those in humans. As in the mouse, the phenotype of human NKX2-5 mutations may be modulated by interacting alleles.
Cell lineage, cell death, and the developmental origin of identified serotonin- and dopamine-containing neurons in the leech

The nervous system of the glossiphoniid leech includes segmentally iterated neurons that contain serotonin (5-HT) and dopamine. These have been investigated in Helobdella triserialis, Theromyzon rude, and Haementeria ghilianii. Five types of 5-HT neurons are identified by immunocytochemistry in the abdominal ganglia of the ventral nerve cord: the bilaterally paired Retzius, anteromedial, ventrolateral and dorsolateral neurons, and the unpaired posteromedial (pm) neuron. Three types of bilaterally paired dopamine neurons are identified by glyoxylic acid-induced fluorescence in the segmental body wall: MD, LD1, and LD2. Each left or right half of the segmental complement of the leech nervous system is known to develop from 6 distinct ectodermal primary blast cells (ns, nf, o, p, qs, and qf). To identify the blast cells of origin of the 5-HT and dopamine neurons, fluorescent cell lineage tracers were injected into the various precursors of the blast cells in early (stage 6) embryos. The embryos were then raised until their 5-HT and dopamine neurons could be scored (stage 11) for the presence or absence of lineage tracer. We find that the Retzius, anteromedial, and posteromedial 5-HT neurons are derived from the ns blast cell, while the ventrolateral and dorsolateral 5-HT neurons are derived from the nf blast cell. The unpaired pm 5-HT neuron arises as one of a bilateral pair of neurons, of which one later dies. Whether the left or right pm neuron survives in any given ganglion is the consequence of some form of competitive interaction between cells derived from the left and right n primary blast cells, possibly between the left and right pm neurons themselves. We find that, of the dopamine neurons, the LD1 neuron is derived from the o blast cell, the LD2 neurons from the p blast cell, and the MD neuron from one of the 2 kinds of q blast cells. These results show that the 5-HT and dopamine neurons arise from 5 different primary blast cells in a highly determinate manner, and they support the view that cells of a similar phenotype need not be closely related in the developmental cell lineage tree.
Diabetes and pulmonary tuberculosis: a global overview with special focus on the situation in Asian countries with high TB-DM burden

ABSTRACT Background: The double burden of tuberculosis (TB) and diabetes mellitus (DM) is hitting certain Asian countries harder than other areas. In a global estimate, 15% of all TB cases could be attributable to DM, with 40% of those cases coming from India and China. Many other countries of South, East, and South-East Asia are of particular concern given their TB burdens, large projected increases in DM prevalence, and population size. Objective: In this narrative review, we aimed to: (i) give an overall insight into the evidence on TB-DM epidemiology from high double burden Asian countries, (ii) present the evidence on bi-directional screening implementation in this region, (iii) discuss possible factors related to higher TB susceptibility of Asian diabetic patients, and (iv) identify TB-DM comorbidity treatment challenges. Methods: The PubMed and Google Scholar databases were searched for all studies addressing DM/TB epidemiology, bi-directional screening and management in South, East and South-East Asia. Results: We identified the DM prevalences among TB patients as ranging from approximately 5% to more than 50%, whereas TB prevalences among diabetic patients were 1.8–9.5 times higher than in the general population in developing Asian countries. Evidence from studies designed to address diagnosis and treatment of the dual disease in these critical regions is scarce as well as the evidence related to possible DM patients’ genetic and acquired predisposition for TB. Conclusion: More prospective studies specifically designed to address adequate screening techniques, identify patients at risk, and define an adequate treatment of dual disease in this region are needed without delay.
Exploring the Duality between Product and Organizational Architectures: A Test of the Mirroring Hypothesis

A variety of academic studies argue that a relationship exists between the structure of an organization and the design of the products that this organization produces. Specifically, products tend to “mirror” the architectures of the organizations in which they are developed. This dynamic occurs because the organization's governance structures, problem solving routines and communication patterns constrain the space in which it searches for new solutions. Such a relationship is important, given that product architecture has been shown to be an important predictor of product performance, product variety, process flexibility and even the path of industry evolution.