Miracle-dz/UniFAR-FTUs huggingface dataset:
ABNORMAL RETURN DANVOLUME PERDAGANGAN SAHAM DI SEPUTARPENGUMUMAN KEBIJAKAN PERUBAHAN KUOTA LOT SAHAM(STUDI KASUS PADA PERUSAHAAN-PERUSAHAAN YANG MASUKDALAM KELOMPOK JAKARTA ISLAMIC INDEX)

Untuk meningkatkan pasar modal agar lebih bergairah lagi serta mempertimbangkan risiko investasi yang cukup besar bagi investor, Bursa Efek Indonesia mengambil salah satu kebijakan dengan mengubah ukuran satuan perdagangan (lot size). Hal ini dituangkan dalam Keputusan Direksi PT Bursa Efek Indonesia No.Kep-00071/BEI.PSH/11-2013 telah ditetapkan Perubahan/ Penambahan Peraturan Nomor II-A tentang Perdagangan Efek Bersifat Ekuitas (khususnya terkait dengan perubahan ukuran satuan perdagangan), dengan ini diumumkan mengenai perubahan atas ukuran satuan perdagangan (lot size). Yaitu ditetapkan dari semula 500 efek bersifat ekuitas, diubah menjadi 100 efek bersifat ekuitas di pasar regular dan pasar tunai. Penelitian ini bertujuan untuk mengetahui dan menjelaskan perbedaan abnormal return dan trading volume activity sebelum dan sesudah tanggal pengumuman kebijakan perubahan kuota lot saham. Penelitian ini menggunakan periode pengamatan 7 hari sebelum pengumuman kebijakan perubahan kuota lot saham dan 7 hari sesudah pengumuman kebijakan perubahan kuota lot saham. Metode yang digunakan dalam penelitian ini adalah event study yang akan mengamati pergerakan abnormal return dan trading volume activity antara sebelum dan sesudah pengumuman kebijakan perubahan kuota lot saham di Bursa Efek Indonesia. Untuk menguji adanya perbedaan abnormal return, dan trading volume activity antara sebelum dan sesudah pengumuman kebijakan perubahan kuota lot saham dilakukan uji beda dua rata-rata menggunakan paired sample t- Test. Hipotesis dalam penelitian ini adalah ada perbedaan yang signifikan antara abnormal return dan trading volume activity sebelum dan sesudah tanggal pengumuman kebijakan perubahan kuota lot saham. Hasil dari penelitian ini mempunyai nilai signifikan lebih besar dari pada 0,05 yaitu 0,711, yang menyatakan bahwa pada abnormal return tidak terkandung informasi terhadap investor dengan diumumkannya kebijakan perubahan kuota lot saham. Hasil pengujian kedua yang dilakukan juga menjelaskan bahwa tidak terdapat perbedaan yang signifikan pada rata-rata trading volume activity sebelum dan sesudah peristiwa dengan nilai signifikan lebih besar dari pada 0,05 yaitu 0,817. Hal ini dikarenakan investor lebih bisa mengenali pasar yang ada sehingga tidak terjadi kepanikan akibat peristiwa tersebut. Investor lebih memilih untuk menunggu sampai pada kebijakan perubahan kuota lot saham diberlakukan.
The Emptiness of the Stratigraphic Record: A Preliminary Evaluation of Missing Time In the Mesaverde Group, Book Cliffs, Utah, U.S.A.

Abstract Observations of modern sedimentation rates in nonmarine and shallow-marine clastic environments indicate that deposits formed in comparable settings in the ancient record could accumulate in a fraction of the time that would appear to be available according to conventional chronostratigraphic dating methods. Typically as little as 10% of elapsed time is represented by sediment, the remainder by breaks in sedimentation, many of which are inconspicuous. An examination of the chronostratigraphy and sedimentary history of the Mesaverde Group of the Book Cliffs, Utah, U.S.A. , confirms this pattern. Shoreface, deltaic, and nonmarine successions are considered to be particularly fragmentary. Ravinement surfaces may each account for up to 105 years of missing time. In the sedimentary record of shallow-marine and nonmarine deposits stratigraphic continuity is not to be expected, and calculation of time-related issues, such as mass-balance transport rates and the trajectories of shoreline transgression and regression, must take this into account.
Genetic Polymorphism in p53 Codon 72 and Skin Cancer in Southwestern Taiwan

Abstract The Pro/Pro polymorphism of p53 codon 72 has been reported to be related to bladder and lung cancer, but its relationship with skin cancer is unclear. We assessed the hypothesis that there is a relationship between the p53 codon 72, Pro/Pro polymorphism, cumulative arsenic exposure, and the risk of skin cancer in a hospital-based case–control study in southwestern Taiwan. From 1996 to 1999, 93 newly-diagnosed skin cancer patients at the National Cheng-Kung University (NCKU) Hospital and 71 community controls matched on residence were recruited in southwestern Taiwan. The genotype of p53 codon 72 (Arg/Arg, Arg/Pro, or Pro/Pro) was determined for all subjects by polymerase chain reaction-restricted fragment length polymorphism (PCR-RFLP). A questionnaire was administered to each subject for collection of demographic information, personal habits, disease history, diet information, and other relevant questions. The Pro/Pro (homozygous) genotype was more frequent in skin cancer patients (cases, 20%; controls, 12%; P = 0.37). Subjects with the susceptible genotype Pro/Pro and heterozygous (intermediate) genotype Pro/Arg had 2.18 and 0.99 times risk of skin cancer than the wild type Arg/Arg (95% confidence interval, 0.74–4.38; 95% confidence interval, 0.44–2.21), respectively. Compared with subjects with 18.518. 5 had 5.78 times risk of skin cancer (95% confidence interval, 1.06 to 31.36) after adjusting for other risk factors. There was no interaction between BMI and genotype, but the sample size was small. The risk of skin cancer did not significantly vary by tumor cell-type. The risk of skin cancer is increased in individuals with the Pro/Pro genotype. Larger, confirmatory studies are needed to clarify the role of constitutional polymorphisms in p53 and skin cancer risk.
On the influence of affective states on intuitive coherence judgements

Recent research has shown that coherence judgements of semantically related word triads are facilitated by a subtle positive response triggered by their increased fluency of processing. Such positive affective response serves as a cue indicating semantic coherence. However, we argue that the fluency of processing is not the only source of affective response that can influence intuitive judgements. The present study investigated differential influences of mood and affective valence of solution words on intuitive coherence judgements. We show that affective cues resulting from processing fluency can be strengthened or weakened by inducing positive or negative affective response through the activation of solutions to semantically coherent triads. Also, mood is shown to impact the breadth of activated associations therefore affecting not only judgements of semantic coherence but also solvability of word triads. We discuss the implications of our findings for how people might form intuitive judgements of semantic coherence.
The Dexamethasone Suppression Test and Long-Term Contraceptive Treatment: Measurement of ACTH or Salivary Cortisol Does Not Improve the Reliability of the Test

Under the influence of high estrogen levels, the suppression of total serum cortisol in the dexamethasone test has often been found to be incomplete. Its measurement for the purpose of excluding Cushing's disease or adrenal tumors in women taking oral contraceptives is, therefore, considered unreliable. This study was designed to compare the reliability of measurements of total cortisol, unbound cortisol and ACTH suppression during chronic hyperestrogenaemia. An overnight suppression test with 2 mg of dexamethasone was performed in 19 women receiving long-term contraceptive treatment (group A) and in 12 controls (group C). Baseline and post-dexamethasone morning levels of ACTH, total serum cortisol and unbound salivary cortisol were determined by RIA. In addition, unbound serum cortisol was measured by equilibrium dialysis. Mean baseline levels of all four parameters were significantly higher in group A. This result points towards the possibility of a direct stimulatory effect of estrogens upon the corticotroph axis which is independent from CBG-mediated increase of total cortisol. Post-dexamethasone values of total and unbound cortisol showed no statistically significant differences, while ACTH suppression in group A was even slightly better than in group C. From these data it is concluded that there is no need for post-dexa routine measurement of ACTH or unbound cortisol under contraceptive treatment since neither one of these parameters provides any additional information in comparison to total cortisol.
Confined compression of canine annulus fibrosus under chemical and mechanical loading.

Uniaxial confined compression and swelling experiments on cylindrical specimens taken either in an axial or in a radial direction from a canine lumbar annulus fibrosus are presented. The loading protocol consisted of a combination of stepwise mechanical and chemical loading. Swelling and consolidation curves of normalized displacement versus square root of normalized time did not show a dependence on site or orientation of the specimen. All stages in which height increases, namely, conditioning, swelling, and desolidation show only slight differences in these normalized curves. Consolidation is initially faster, and later slower. The transport coefficient for axial specimens is higher than for radial specimens, for consolidation e.g., 3.14 +/- 1.56 10(-10) m2s(-1) and 1.11 +/- 0.33 10(-10) m2s(-1) respectively, the biphasic aggregate moduli are 1.01 +/- 0.31 MPa and 0.66 +/- 0.30 MPa, respectively.
An Assessment of the Biases of Satellite Rainfall Estimates over the Tibetan Plateau and Correction Methods Based on Topographic Analysis

Abstract The hydrological processes over the Tibetan Plateau have significant implications on regional macroscale atmospheric circulation patterns and the Asian monsoon system. Because of its remote setting and lack of ground observations, it is difficult to study the spatial and temporal patterns of precipitation over the plateau, and satellite remote sensing technology can be used to fill in the gaps where station data are not available. In this study the authors examine monthly 1° × 1° rainfall estimates obtained from the Special Sensor Microwave Imager (SSM/I) [National Environmental Satellite, Data, and Information Service (NESDIS) algorithm] and Tropical Rainfall Measuring Mission (TRMM) 3B42 version 5 (V5) products for the months of April–October 1998–2002 over the Tibetan Plateau. By comparing the satellite estimates with ground observations at 94 weather stations in the study region, the authors derived regression models that produced significant improvements to satellite estimates based on vario.
Response to DNA damage: why do we need to focus on protein phosphatases?

Eukaryotic cells are continuously threatened by unavoidable errors during normal DNA replication or various sources of genotoxic stresses that cause DNA damage or stalled replication. To maintain genomic integrity, cells have developed a coordinated signaling network, known as the DNA damage response (DDR). Following DNA damage, sensor molecules detect the presence of DNA damage and transmit signals to downstream transducer molecules. This in turn conveys the signals to numerous effectors, which initiate a large number of specific biological responses, including transient cell cycle arrest mediated by checkpoints, DNA repair, and apoptosis. It is recently becoming clear that dephosphorylation events are involved in keeping DDR factors inactive during normal cell growth. Moreover, dephosphorylation is required to shut off checkpoint arrest following DNA damage and has been implicated in the activation of the DDR. Spatial and temporal regulation of phosphorylation events is essential for the DDR, and fine-tuning of phosphorylation is partly mediated by protein phosphatases. While the role of kinases in the DDR has been well documented, the complex roles of protein dephosphorylation have only recently begun to be investigated. Therefore, it is important to focus on the role of phosphatases and to determine how their activity is regulated upon DNA damage. In this work, we summarize current knowledge on the involvement of serine/threonine phosphatases, especially the protein phosphatase 1, protein phosphatase 2A, and protein phosphatase Mg2+/Mn2+-dependent families, in the DDR.
The Late Triassic (Norian) Adamanian–Revueltian tetrapod faunal transition in the Chinle Formation of Petrified Forest National Park, Arizona

ABSTRACT Recent stratigraphic revisions of the Upper Triassic Chinle Formation of Petrified Forest National Park, in conjunction with precise and accurate documentation of fossil tetrapod occurrences, clarified the local biostratigraphy, with regional and global implications. A significant overlap between Adamanian and Revueltian faunas is rejected, as is the validity of the Lamyan sub-land vertebrate faunachron. The Adamanian–Revueltian boundary can be precisely placed within the lower Jim Camp Wash beds of the Sonsela Member and thus does not occur at the hypothesised Tr-4 unconformity. This mid-Norian faunal turnover, may coincide with a floral turnover, based on palynology studies and also on sedimentological evidence of increasing aridity. Available age constraints bracketing the turnover horizon are consistent with the age of the Manicouagan impact event. The rise of dinosaurs in western North America did not correspond to the Adamanian–Revueltian transition, and overall dinosauromorph diversity seems to have remained at a constant level across it. The paucity of detailed Late Triassic vertebrate biostratigraphic data and radioisotopic dates makes it currently impossible to either support or reject the existence of globally synchronous Late Triassic extinctions for tetrapods.
New Early Devonian brachythoracids (placoderm fishes) from the Taemas - Wee Jasper region of New South Wales

Two new brachythoracids are described from the Taemas Limestone. Arenipiscis westolli gen. et sp. nov. possesses a skull-roof with deeply embayed posterior and elongate anterolateral margins, a large fused rostropineal plate, and orbits anteriorly placed and deeply notching the skull. The visceral skull-roof surface is developed with strong relief. The trunk-shield is poorly known, but the median dorsal plate probably had a prominent carinal process. Errolosteus goodradigbeensis gen. et sp. nov. is known only by an incomplete skull-roof, and anterior lateral and posterior ventrolateral plates. It has a highly distinctive ridged ornament. The affinities of these forms are considered in a discussion of brachythoracid interrelationships, and it is concluded that they are interchangeable on a cladogram with Buchanosteus. Other brachythoracids from the fauna, recently described by White, are considered, and it is suggested that Goodradigbeeon is phyletically primitive and Taemasosteus phyletically advanced rel.
Clinical Pharmacokinetics of Cefamandole and Ceftazidime Administered by Continuous Intravenous Infusion

ABSTRACT In view of the results of animal studies as well as theoretical considerations, continuous administration of β-lactam antibiotics should be superior to intermittent administration because of the close relationship between efficacy and the duration of time in which the concentration of unbound antibiotics in plasma remains above the MIC. The aim of the present study was to establish the pharmacokinetic parameters of cefamandole and ceftazidime for patients receiving these cephalosporins by continuous infusion. The interindividual differences in the concentrations in plasma at the steady state were mainly attributable to variations in renal function, as estimated by the rate of creatinine clearance. Using these results, we derived formulas for both cephalosporins that can be used to determine on an individual basis the total daily dose needed to obtain a therapeutic concentration in plasma. These formulas were tested with a group of subsequent patients and proved to be practical and fairly reliable. For some patients, a correction for a possible underestimation of the renal clearance at presentation might be required.
Efficient peer-to-peer file sharing using network coding in MANET

Mobile peer-to-peer (P2P) systems have recently got in the limelight of the research community that is striving to build efficient and effective mobile content addressable networks. Along this line of research, we propose a new peer-to-peer file sharing protocol suited to mobile ad hoc networks (MANET). The main ingredients of our protocol are network coding and mobility assisted data propagation, i.e., single-hop communication. We argue that network coding in combination with single-hop communication allows P2P file sharing systems in MANET to operate in a more efficient manner and helps the systems to deal with typical MANET issues such as dynamic topology and intermittent connectivity as well as various other issues that have been disregarded in previous MANET P2P researches such as addressing, node/user density, non-cooperativeness, and unreliable channel. Via simulation, we show that our P2P protocol based on network coding and single-hop communication allows shorter file downloading delays compared to an existing MANET P2P protocol.
Efficient Visual Feedback Method to Control a Three-Dimensional Overhead Crane

This paper presents an efficient method to capture the dynamic movement of a three-dimensional (3-D) overhead crane, enabling it to be controlled by visual feedback in real time with two cheap handy cameras. Two tracking areas and one positioning block in each frame are used to search image features and determine the useful vision information. The depth information of 3-D crane system in images can be also obtained by a tag on the dynamic plant. The presented visual tracking method involves comparison of the lightest or darkest points in the tracking or positioning area of a dynamic object and then computes the necessary trolley position and load swing in 3-D space. Upon tracking, the sensing data are sent to an adaptive fuzzy sliding-mode controller (AFSMC) to derive control power for the crane system. Accordingly, the merits of this AFSMC approach, including robustness of the sliding-mode control and the model-free property of the fuzzy logic for the 3-D crane system, are confirmed. Experimental results verify the improvement of the proposed methodology.
Aspect rating analysis based product ranking

Nowadays, the consumer reviews for various products are playing a very important role not only for consumers but also for the firms. A large collection of consumer reviews is now available on the internet. These reviews are very helpful to get quality information about the products. The consumer reviews are used as a feedback by the firms in their product development strategies and consumer relationship management. The consumer reviews contain valuable information still we face difficulties in information navigation due to their disorganized nature. The existing product aspect ranking framework automatically identifies important aspects of products from consumer reviews. There are two important observations to identify important aspects. The large number of consumers usually comments important aspects of the product and the consumers' opinion on those aspects have a great influence on their overall opinion about the product. It uses shallow dependency parser for identifying product aspects and sentiment classifier for determining opinion on those aspects. Finally, it uses a probability aspect ranking algorithm to infer the importance of aspects and ranks it as per their importance score. In this paper, the experimental results confirms the proposed modified system makes the use of aspect rating to improve the performance of important aspect identification and ranking.
Behavioural Reactivation and Subjective Assessment of the State of Vigilance—Application to Simulated Car Driving

The frequency of some behaviour (such as self-centred gestures) increases during a task that leads to the occurrence of low-vigilance episodes. These gestures can be useful in stimulating oneself. A study carried out in 20 adults has enabled us to state that motor activity (recorded with an actimeter) increases with the duration of a monotonous driving task and sleep deprivation. The analysis of the scores recorded using the Karolinska Sleepiness Scale has shown that drivers can assess the deterioration of their state of vigilance according to the actual sleep preceding the driving test. Finally, the joint analysis of the subjective and objective data revealed a co-variation of these two types of indices. We discuss the stimulatory function of the motor activity in a task leading to the occurrence of low-vigilance episodes by investigating, among other things, the use, conscious or not, of this type of activity.
Preassociated apocalmodulin mediates Ca2+-dependent sensitization of activation and inactivation of TMEM16A/16B Ca2+-gated Cl− channels

Significance Calcium-activated chloride channels (CaCCs) encoded by transmembrane members 16A and 16B (TMEM16A/16B) are vital for physiological functions ranging from smooth muscle contraction to cell proliferation and are important therapeutic targets. Here, applying a recently developed bioengineering approach referred to as channel inactivation induced by membrane tethering of an associated protein (ChIMP), we found that the Ca2+-sensing protein calmodulin (CaM) is preassociated with TMEM16A/16B channel complexes in its Ca2+-free state (apoCaM). The preassociated apoCaM acts as a resident Ca2+ sensor that increases Ca2+ sensitivity of TMEM16A/16B activation at low intracellular Ca2+ concentrations and also mediates inactivation of TMEM16A channels at high Ca2+ concentrations. The results reveal a previously unidentified role for apoCaM in Ca2+-dependent regulation of TMEM16A/16B channels that is likely physiologically important, and may be a promising site to target for therapy. Ca2+-activated chloride currents carried via transmembrane proteins TMEM16A and TMEM16B regulate diverse processes including mucus secretion, neuronal excitability, smooth muscle contraction, olfactory signal transduction, and cell proliferation. Understanding how TMEM16A/16B are regulated by Ca2+ is critical for defining their (patho)/physiological roles and for rationally targeting them therapeutically. Here, using a bioengineering approach—channel inactivation induced by membrane-tethering of an associated protein (ChIMP)—we discovered that Ca2+-free calmodulin (apoCaM) is preassociated with TMEM16A/16B channel complexes. The resident apoCaM mediates two distinct Ca2+-dependent effects on TMEM16A, as revealed by expression of dominant-negative CaM1234. These effects are Ca2+-dependent sensitization of activation (CDSA) and Ca2+-dependent inactivation (CDI). CDI and CDSA are independently mediated by the N and C lobes of CaM, respectively. TMEM16A alternative splicing provides a mechanism for tuning apoCaM effects. Channels lacking splice segment b selectively lost CDI, and segment a is necessary for apoCaM preassociation with TMEM16A. The results reveal multidimensional regulation of TMEM16A/16B by preassociated apoCaM and introduce ChIMP as a versatile tool to probe the macromolecular complex and function of Ca2+-activated chloride channels.