Miracle-dz/UniFAR-FTUs huggingface dataset:
A double-labeling investigation of the afferent connectivity to cortical areas V1 and V2 of the macaque monkey

The afferent connectivity of areas V1 and V2 was investigated using the fluorescent dyes fast blue and diamidino yellow. Simultaneous injection of each dye in retinotopically corresponding regions of these areas gave rise to two afferent populations of labeled neurons in subcortical and cortical structures which project to both areas. These two populations showed a variable degree of overlap in their spatial distribution. Neurons labeled by both dyes (double-labeled neurons) which, therefore, project to both areas, were found in substantial numbers in these overlap zones. When the injections were made in non- retinotopically corresponding regions in the two areas, both populations of labeled cells overlapped extensively in the cortex but not in subcortical structures, suggesting that the laws governing the topography of these two types of connections are different. In the cortex, the labeled neurons extended from the fundus of the lunate sulcus to the fundus of the superior temporal sulcus. A few labeled neurons were also found in the inferior temporal cortex and the parahippocampal gyrus. In all cortical regions, corticocortical neurons projecting to V1 and V2 were found in both supra- and infragranular layers, although double-labeled neurons were more numerous in infragranular layers. With increasing distance from V1 there was an increase in the proportion of neurons labeled in infragranular layers. The comparative strength of input to V1 and V2 was computed and was found to be higher to V2 in all cortical regions except the superior temporal sulcus which projected equally heavily to both areas. The superior temporal sulcus also stood out in that of all cortical regions it contained the highest proportion of double-labeled neurons. Single- and double-labeled neurons were found in a number of subcortical structures including the lateral geniculate nucleus, the inferior and lateral pulvinar, the intralaminar nuclei, the nucleus basalis of Meynert, and the amygdala. The pattern of labeling in the lateral pulvinar was in agreement with the suggestion that this structure has a complex topographical organization containing at least a dual representation of the visual field (Bender, D. B. (1981) J. Neurophysiol. 46: 672–693). In the pulvinar complex, densities of labeled neurons permitted evaluation of the strength of input to V1 and V2, the latter being the strongest. These results demonstrate that areas V1 and V2 share a vast amount of common input from the same cortical and subcortical structures and that a number of neurons project to both areas via branching axons.
Abnormal Subjective Time Experience in Depression

Abnormality of subjective time experience is well recognised in psychiatric illness. Earlier authors suggested that slowed time experience in depression is an aspect of psychomotor retardation, while more recently it has been argued that this disturbance is non-specifically linked to the global severity of the depressive syndrome. This study offers evidence that both views can be justified: slowed time awareness is a common symptom of depression, related particularly to retardation, and to the severity of the mood disturbance. Some of the experimental difficulties in this kind of research are illustrated.
Dual response modes in lateral geniculate neurons: Mechanisms and functions

Abstract Relay cells of the lateral geniculate nucleus, like those of other thalamic nuclei, manifest two distinct response modes, and these represent two very different forms of relay of information to cortex. When relatively hyperpolarized, these relay cells respond with a low threshold Ca2+ spike that triggers a brief burst of conventional action potentials. These cells switch to tonic mode when depolarized, since the low threshold Ca2+ spike, being voltage dependent, is inactivated at depolarized levels. In this mode they relay information with much more fidelity. This switch can occur under the influence of afferents from the visual cortex or parabrachial region of the brain stem. It has been previously suggested that the tonic mode is characteristic of the waking state while the burst mode signals an interruption of the geniculate relay during sleep. This review surveys the key properties of these two response modes and discusses the implications of new evidence that the burst mode may also occur in the waking animal.
Smoothing and worst-case complexity for direct-search methods in nonsmooth optimization

For smooth objective functions it has been shown that the worst case cost of direct-search methods is of the same order as the one of steepest descent, when measured in number of iterations to achieve a certain threshold of stationarity. Motivated by the lack of such a result in the non-smooth case, we propose, analyze, and test a class of smoothing direct-search methods for the optimization of non-smooth functions. Given a parameterized family of smoothing functions for the non-smooth objective function, this class of methods consists of applying a direct-search algorithm for a fixed value of the smoothing parameter until the step size is relatively small, after which the smoothing parameter is reduced and the process is repeated. One can show that the worst case complexity (or cost) of this procedure is roughly one order of magnitude worse than the one for direct search or steepest descent on smooth functions. The class of smoothing direct-search methods is also showed to enjoy asymptotic global convergence properties. Some preliminary numerical experience indicates that this approach leads to better values of the objective function, pushing in some cases the optimization further, apparently without an additional cost in the number of function evaluations.
Water-induced finger wrinkles improve handling of wet objects

Upon continued submersion in water, the glabrous skin on human hands and feet forms wrinkles. The formation of these wrinkles is known to be an active process, controlled by the autonomic nervous system. Such an active control suggests that these wrinkles may have an important function, but this function has not been clear. In this study, we show that submerged objects are handled more quickly with wrinkled fingers than with unwrinkled fingers, whereas wrinkles make no difference to manipulating dry objects. These findings support the hypothesis that water-induced finger wrinkles improve handling submerged objects and suggest that they may be an adaptation for handling objects in wet conditions.
Dexrazoxane for Preventing Anthracycline Cardiotoxicity in Children with Solid Tumors

This study attempted to assess the incidence and outcome of anthracycline cardiotoxicity and the role of dexrazoxane as a cardioprotectant in childhood solid tumors. The dexrazoxane group included 47 patients and the control group of historical cohort included 42. Dexrazoxane was given in the 10:1 ratio to doxorubicin. Fractional shortening and systolic and diastolic left ventricular diameters were used to assess the cardiac function. The median follow-ups were 54 months in the dexrazoxane group and 86 months in the control group. The mean cumulative doses of doxorubicin were 280.8±83.4 mg/m2 in the dexrazoxane group and 266.1±75.0 mg/m2 in the control group. The dexrazoxane group experienced significantly fewer cardiac events (27.7% vs. 52.4%) and less severe congestive heart failure (6.4% vs. 14.3%) than the control group. Thirteen cardiotoxicities including one cardiac death and 2 congestive heart failures occurred in the dexrazoxane group, and 22 cardiotoxicities including 2 cardiac deaths and 4 congestive heart failures, in the control group. Five year cardiac event free survival rates were 69.2% in the dexrazoxane group and 45.8% in the control group (P=0.04). Dexrazoxane reduces the incidence and severity of early and late anthracycline cardiotoxicity in childhood solid tumors.
Predictors of lapse in first week of smoking abstinence in PTSD and non-PTSD smokers.

INTRODUCTION Retrospective research suggests smokers with posttraumatic stress disorder (PTSD) lapse more quickly after their quit date. Ecological momentary assessment (EMA) research is needed to confirm the presence of early smoking lapse in PTSD and form conceptualizations that inform intervention. METHODS Smokers with (n = 55) and without (n = 52) PTSD completed alarm-prompted EMA of situational and psychiatric variables the week before and after a quit date, and self-initiated EMA following smoking lapses. Blood samples at baseline and on the quit date allowed assessment of dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEA(S)). RESULTS PTSD was related to shorter time to lapse (hazard ratio [HR] = 1.677, 95% CI: 1.106-2.544). Increased smoking abstinence self-efficacy was related to longer time to lapse (HR = 0.608, 95% CI: 0.430-0.860). Analyses of participants' real-time reports revealed that smokers with PTSD were more likely to attribute first-time lapses to negative affect ( = 5.412, p = .020), and trauma reminders (Fisher's exact p = .003**). Finally, the quit date decrease in DHEA(S) was related to shorter time to lapse (HR = 1.009, 95% CI: 1.000-1.018, p < .05). CONCLUSIONS Results provide evidence of shorter time to first smoking lapse in PTSD, and add to evidence that early lapse occasions are more strongly related to trauma reminders, negative affect, and cravings in smokers with PTSD.
Winter at the Alpine Timberline. Why Does Embolism Occur in Norway Spruce But Not in Stone Pine?1

Conifers growing at the alpine timberline are exposed to frost drought and freeze-thaw cycles during winter—stress factors known to induce embolism in tree xylem. The two dominant species of the European Central Alps timberline were studied: Norway spruce (Picea abies [L.] Karst) and stone pine (Pinus cembra), which usually reaches higher altitudes. We hypothesized to find embolism only at the timberline and to observe less embolism in stone pine than in Norway spruce due to avoidance mechanisms. Seasonal courses of embolism and water potential were studied at 1,700 and 2,100 m during two winter seasons and correlated to vulnerability (to drought-induced embolism), leaf conductance, and micrometeorological data. Embolism was observed only at the timberline and only in Norway spruce (up to 49.2% loss of conductivity). Conductivity losses corresponded to low water potentials (down to −3.5 MPa) but also to the number of freeze-thaw events indicating both stress factors to contribute to embolism induction. Decreasing embolism rates—probably due to refilling—were observed already in winter. Stone pine did not exhibit an adapted vulnerability (50% loss of conductivity at −3.5 MPa) but avoided critical potentials (minimum −2.3 MPa): Cuticulare conductance was 3.5-fold lower than in Norway spruce, and angles between needles and axes were found to decrease in dehydrating branches. The extent of conductivity losses in Norway spruce and the spectrum of avoidance and recovery mechanisms in both species indicates winter embolism to be relevant for tree line formation.
Expression of extracellular matrix genes in cultured hepatic oval cells: an origin of hepatic stellate cells through transforming growth factor beta?

Background: Hepatic oval cells, progenitor cells in the liver, can differentiate into hepatocytes and bile duct cells both in vitro and in vivo. Although hepatic stellate cells are another important cell component in the liver, less attention has been focused on the relationship between hepatic oval cells and hepatic stellate cells.
Hunting to extinction: biology and regional economy influence extinction risk and the impact of hunting in artiodactyls

Half of all artiodactyls (even-toed hoofed mammals) are threatened with extinction, around double the mammalian average. Here, using a complete species-level phylogeny, we construct a multivariate model to assess for the first time which intrinsic (biological) and extrinsic (anthropogenic and environmental) factors influence variation in extinction risk in artiodactyls. Globally artiodactyls at greatest risk live in economically less developed areas, have older weaning ages and smaller geographical ranges. Our findings suggest that identifying predictors of threat is complicated by interactions between both biological and anthropogenic factors, resulting in differential responses to threatening processes. Artiodactyl species that experience unregulated hunting live in significantly less economically developed areas than those that are not hunted; however, hunted species are more susceptible to extinction if they have slower reproductive rates (older weaning ages). In contrast, risk in non-hunted artiodactyls is unrelated to reproductive rate and more closely associated with the economic development of the region in which they live.
Size at Birth, Weight Gain in Infancy and Childhood, and Adult Diabetes Risk in Five Low- or Middle-Income Country Birth Cohorts

OBJECTIVE We examined associations of birth weight and weight gain in infancy and early childhood with type 2 diabetes (DM) risk in five cohorts from low- and middle-income countries. RESEARCH DESIGN AND METHODS Participants were 6,511 young adults from Brazil, Guatemala, India, the Philippines, and South Africa. Exposures were weight at birth, at 24 and 48 months, and adult weight, and conditional weight gain (CWG, deviation from expected weight gain) between these ages. Outcomes were adult fasting glucose, impaired fasting glucose or DM (IFG/DM), and insulin resistance homeostasis model assessment (IR-HOMA, three cohorts). RESULTS Birth weight was inversely associated with adult glucose and risk of IFG/DM (odds ratio 0.91[95% CI 0.84–0.99] per SD). Weight at 24 and 48 months and CWG 0–24 and 24–48 months were unrelated to glucose and IFG/DM; however, CWG 48 months–adulthood was positively related to IFG/DM (1.32 [1.22–1.43] per SD). After adjusting for adult waist circumference, birth weight, weight at 24 and 48 months and CWG 0–24 months were inversely associated with glucose and IFG/DM. Birth weight was unrelated to IR-HOMA, whereas greater CWG at 0–24 and 24–48 months and 48 months–adulthood predicted higher IR-HOMA (all P < 0.001). After adjusting for adult waist circumference, birth weight was inversely related to IR-HOMA. CONCLUSIONS Lower birth weight and accelerated weight gain after 48 months are risk factors for adult glucose intolerance. Accelerated weight gain between 0 and 24 months did not predict glucose intolerance but did predict higher insulin resistance.
Visual-weighted motion compensation frame interpolation with motion vector refinement

In this paper, we propose a novel frame rate up-conversion algorithm based on joint motion vector refinement and visual-weighted motion compensation interpolation (MCI). It utilizes a hierarchical motion vector refinement to correct inaccurate motion vectors (MVs), which is composed of the global level and the local level. In the global level, distinct inaccurate MVs are detected by global controlling and then corrected by neighborhood information. Afterwards, the local level performs the local controlling to pick out local outliers and re-estimate them with the maximum likelihood method. Finally, plausible weights for each block in the interpolated frame, computed by the similarity index(SSIM), are applied for visual compensation. The experimental results demonstrate that compared with the conventional algorithm EBME, the proposed algorithm achieved the average PSNR by up to 2.7dB while the visual quality improvement is also remarkable.
Polymorphism of myosin among skeletal muscle fiber types

An immunocytochemical approach was used to localize myosin with respect to individual fibers in rat skeletal muscle. Transverse cryostat sections of rat diaphragm, a fast-twitch muscle, were exposed to fluorescein-labeled immunoglobulin against purified chicken pectoralis myosin. Fluorescence microscopy revealed a differential response among fiber types, identified on the basis of mitochondrial content. All white and intermediate fiber but only about half of the red fiber reacted with his antimyosin. In addition, an alkali-stable ATPase had the same pattern of distribution among fibers, which is consistent with the existence of two categories of red fibers. The positive response of certain red fibers indicates either that their myosin has antigenic determinants in common with "white" myosin, or that the immunogen contained a "red" myosin. Myosin, extracted from a small region of the pectorlis which consists entirely of white fibers, was used to prepare an immunoadsorbent column to isolate antibodies specific for white myosin. This purified anti-white myosin reacted with the same fibers of the rat diaphragm that had reacted with the white, intermediate, and some red fibers are sufficiently homologous to share antigenic determinants. In a slow-twitch muscle, the soleus, only a minority of the fiber reacted with antipectoralis myosin. The majority failed to respond; hence, they are not equivalent to intermediate fibers of the diaphragm; despite their intermediate mitochondrial content. Immunocytochemical analysis of two different musles of the rat has demonstrated that more than one isoenzyme of myosin can exist in a single muscle, and that individual fiber types can be recognized by immunological differences in their myosin. We conclude that, in the rat diaphragm, there are at least two immunochemically distinct types of myosin and four types of muscle fibers: white, intermediate, and two red. We suggest that these fibers correspond to the four types of motor units described by Burke et al. (Burke, R. E., D. N. Levine, P. Tsairis, and F. E. Zajac, III 1973. J. Physiol. (Lond) 234:723-748. )in the cat gastrocnemius. `
Recursive Algorithms and Systolic Architectures for Realization of Type-II Discrete Cosine Transform and Inverse Discrete Cosine Transform

The paper presents novel recursive algorithms for realization of one-dimensional type-II discrete cosine transform (DCT) and inverse discrete cosine transform (IDCT) of any length. By using some mathematical techniques, recursive expressions for DCT and IDCT have been developed. The number of additions and multiplications in the recursive algorithm for DCT are less in comparison with some other DCT algorithms. Basing on these two recursive algorithms, two systolic architectures are presented for realization of DCT and IDCT. The recursive algorithms are appropriate for VLSI implementation. Keywords-Discrete cosine transform, Inverse discrete cosine transform, Recursive algorithm, Systolic architecture.
Fast zonal DCT-based image compression for Wireless Camera Sensor Networks

This paper deals with image compression over Wireless Camera Sensor Networks (WCSNs) in order to decrease the energy consumption of sensors and thus to maintain a long network lifetime. As the radio tranceiver is the most power greedy components of sensor nodes, it seems natural to consider lossy compression before transmission as the appropriate answer to the problem of energy consumption. However, the limitation of sensor nodes in terms of memory as well as processor speed makes most of the compression algorithms inapplicable. Indeed, the most popular methods such as JPEG or JPEG2000 can yield a higher energy consumption than when transmitting uncompressed images. Here we propose to solve this problem by the design of a fast zonal DCT-based image compression algorithm which allows an efficient tuning of the trade-off between energy consumption and image distortion, as shown by experimental results provided in the paper.
Molecular anatomy of breast cancer stroma and its prognostic value in estrogen receptor-positive and -negative cancers.

PURPOSE The purpose of this study was to identify genes enriched in breast cancer stroma, assess the stromal gene expression differences between estrogen receptor (ER) -positive and -negative cancers, and separately determine their prognostic value in these two subtypes of breast cancers. METHODS We compared gene expression profiles of pairs of fine-needle (stroma-poor) and core-needle (stroma-rich) biopsies from 37 cancers to identify stroma-associated genes. We defined stromal metagenes and tested their prognostic values in 684 node-negative patients who received no systemic adjuvant therapy and 259 tamoxifen-treated patients. RESULTS We identified 293 probe sets overexpressed in core biopsies; these included five highly coexpressed gene clusters (metagenes) corresponding to immune functions and extracellular matrix components. These genes showed quantitative and qualitative differences between ER-positive and ER-negative cancers. A B-cell/plasma cell metagene showed strong prognostic value in ER-positive highly proliferative cancers, a lesser prognostic value in ER-negative cancers, and no prognostic value in ER-positive cancers with low proliferation. The hazard ratio for distant relapse in the lowest compared with the highest tertile of the pooled prognostic data set was 4.29 (95% CI, 2.04 to 9.01; P = .001) in ER-positive cancers and 3.34 (95% CI, 1.60 to 6.97; P = .001) in ER-negative cancers. This remained significant in multivariate analysis including routine variables and other genomic prognostic scores. As a result of quantitative differences in this metagene between ER-positive and ER-negative cancers, different thresholds apply in the two subgroups. Other stromal metagenes had inconsistent prognostic value. CONCLUSION Among ER-negative and ER-positive highly proliferative cancers, a subset of tumors with high expression of a B-cell/plasma cell metagene carries a favorable prognosis.
The Equilibrium Dynamics of Liquidity and Illiquid Asset Prices

When purchasing a security an investor needs not only have in mind the cash ows that the security will pay into the inde nite future, he/she must also anticipate his/her desire and ability to resell the security in the marketplace at a later point in time. In this paper, we show that the endogenous stochastic process of the liquidity of securities is as important to investment and valuation as is the stochastic process of their future cash ows. We, therefore, develop a general equilibrium model with heterogeneous agents that have an every day motive to trade. Our method delivers the optimal, market-clearing moves of each investor and the resulting ticker and transactions prices in the presence of transaction costs. We use it to show the e¤ect of transactions costs on asset prices, on deviations from the classic consumption CAPM and on the time path of transactions prices and trades, including their total and quadratic variations. We also show that transactions costs can explain some of the empirical asset-pricing anomalies. Buss is with Goethe University, Frankfurt (buss@ nance.uni-frankfurt.de) and Dumas is with INSEAD, NBER and CEPR (bernard.dumas@insead.edu). Work on this topic was initiated while Dumas was at the University of Lausanne. The authors are grateful for useful discussions to Yakov Amihid, Bruno Biais, Xi Dong, Harald Hau, Julien Hugonnier, Pascal Maenhout, Raman Uppal and Grigory Vilkov.