Miracle-dz/UniFAR-FTUs huggingface dataset:
X-ray detection of the proto supermassive binary black hole at the centre of Abell 400

Context. We report the first X-ray detection of a proto supermassive binary black hole at the centre of Abell 400. Using the Chandra Advanced CCD Imaging Spectrometer , we are able to clearly resolve the two active galactic nuclei in 3C 75, the well known double radio source at the centre of Abell 400. Aims. Through analysis of the new Chandra observation of Abell 400 along with 4.5 GHz and 329 MHz Very Large Array radio data, we will show new evidence that the active galactic nuclei in 3C 75 are a bound system. Methods. Using the high quality X-ray data, we map the temperature, pressure, density and entropy of the inner regions as well as the cluster profile properties out to ${\sim}18\arcmin$. We compare features in the X-ray and radio images to determine the interaction between the intracluster medium and extended radio emission. Results. The Chandra image shows an elongation of the cluster gas along the northeast-southwest axis; aligned with the initial bending of 3C 75's jets. Additionally, the temperature profile shows no cooling core, consistent with a merging system. There is an apparent shock to the south of the core consistent with a Mach number of ${\cal M}\sim1.4$ or speed of $v\sim1200$ km s -1 . Both active galactic nuclei, at least in projection, are located in the low entropy, high density core just north of the shock region. We find that the projected path of the jets does not follow the intra-cluster medium surface brightness gradient as expected if their path were due to buoyancy. We also find that both central active galactic nuclei are extended and include a thermal component. Conclusions. Based on this analysis, we conclude that the active galactic nuclei in 3C 75 are a bound system from a previous merger. They are contained in a low entropy core moving through the intracluster medium at 1200 km s -1 . The bending of the jets is due to the local intracluster medium wind.
Why Do We Need Doctoral Study in Design

Many of the interviews and presentations I do today address the question: why do we need doctoral study in design? This question most often comes from practitioners and faculty in a field that has only a short history of research and a long tradition of training in know-how, in the craft of solving problems with the information immediately at hand. It is a reasonable question to ask about a field that is not well understood by the public or by popular media that view design mostly in terms of how things look. But ironically, the greatest skepticism about expanding design research programs seems to reside within the discipline itself, where there is ongoing debate about what constitutes design knowledge. By contrast, the notion of a design research culture does not seem odd to people in fields outside design, where among the defining characteristics of professions, as opposed to trades, are segments of practice in which the sole activity is the generation of new knowledge. There is broad recognition that knowledge generation sustains the evolution of a discipline and particular interest in the value of design research in cross-disciplinary investigations. In this commentary, therefore, I first make a case for why design research is important to contemporary design practice and the deepening of the design disciplines, especially at this point in our history. Further, I address the trajectory of design research programs in universities and talk about the pre-requisite conditions for establishing research degrees. This paper is from the perspective of design in the United States of America (USA), where design research has been especially slow to develop. Discussions of these issues pervade the field worldwide, however, and several working groups have been established to debate these very topics for publication in the coming year.
Improved DWT Based Watermarking Using JPEG-YCbCr

In this paper a blind, Secure, imperceptible and robust watermarking algorithm based on wavelet transform domain is proposed in which for more security, the watermark W is converted to a sequence and then a random binary sequence R of size n is adopted to encrypt the watermark, where n is the size of the watermark image. Afterwards, the encrypted watermark sequence W1 is generated by executing exclusive-OR operation on W and R. This generated watermark embeds into low frequency selected coefficients of Y channel wavelet decomposition of JPEG-YCbCr using LSB insertion technique. The experimental results show that the proposed algorithm increases the security and imperceptibility of watermark and has better robustness against wavelet compression and cropping attacks compared to the earlier work in [1].
Antecedent Selection for Sluicing: Structure and Content

Sluicing is an elliptical process where the majority of a question can go unpronounced as long as there is a salient antecedent in previous discourse. This paper considers the task of antecedent selection: ﬁnding the correct antecedent for a given case of sluicing. We argue that both syntactic and discourse relationships are important in antecedent selection, and we construct linguistically sophisticated features that describe the relevant relationships. We also deﬁne features that describe the relation of the content of the antecedent and the sluice type. We develop a linear model which achieves accuracy of 72.4%, a substantial improvement over a strong manually constructed baseline. Feature analysis conﬁrms that both syntactic and discourse features are important in antecedent selection.
Concentration dependence of lipopolymer self-diffusion in supported bilayer membranes

Self-diffusion coefficients of poly(ethylene glycol)2k-derivatized lipids (DSPE-PEG2k-CF) in glass-supported DOPC phospholipid bilayers are ascertained from quantitative fluorescence recovery after photobleaching (FRAP). We developed a first-order reaction–diffusion model to ascertain the bleaching constant, mobile fraction and lipopolymer self-diffusion coefficient Ds at concentrations in the range c ≈ 0.5–5 mol%. In contrast to control experiments with 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(7-nitro-2-1,3-benzoxadiazol-4-yl) (ammonium salt) (DOPE-NBD) in 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC), the lipopolymer self-diffusion coefficient decreases monotonically with increasing concentration, without a distinguishing mushroom-to-brush transition. Our data yield a correlation Ds = D0/(1 + αc), where D0 ≈ 3.36 µm2 s−1 and α ≈ 0.56 (with c expressed as a mole percent). Interpreting the dilute limit with the Scalettar–Abney–Owicki statistical mechanical theory for transmembrane proteins yields an effective disc radius ae ≈ 2.41 nm. On the other hand, the Bussell–Koch–Hammer theory, which includes hydrodynamic interactions, yields ae ≈ 2.92 nm. As expected, both measures are smaller than the Flory radius of the 2 kDa poly(ethylene glycol) (PEG) chains, RF ≈ 3.83 nm, and significantly larger than the nominal radius of the phospholipid heads, al ≈ 0.46 nm. The diffusion coefficient at infinite dilution D0 was interpreted using the Evans–Sackmann theory, furnishing an inter-leaflet frictional drag coefficient bs ≈ 1.33 × 108 N s m−3. Our results suggest that lipopolymer interactions are dominated by the excluded volume of the PEG-chain segments, with frictional drag dominated by the two-dimensional bilayer hydrodynamics.
Neural network based arrhythmia classification using Heart Rate Variability signal

Heart Rate Variability (HRV) analysis is a non-invasive tool for assessing the autonomic nervous system and specifically it is a measurement of the interaction between sympathetic and parasympathetic activity in autonomic functioning. In recent years, HRV signal is mostly noted for automated arrhythmia detection and classification. In this paper, we have used a neural network classifier to automatic classification of cardiac arrhythmias into five classes. HRV signal is used as the basic signal and linear and nonlinear parameters extracted from it are used to train a neural network classifier. The proposed approach is tested using the MIT-BIH arrhythmia database and satisfactory results were obtained with an accuracy level of 99.38%.
The application of compressive sampling to the analysis and synthesis of spatial sound fields

Compressive sampling provides a new and interesting tool to optimise measurements of physical phenomena with a small number of sensors. The essential idea is that close to perfect reconstruction of the observed phenomenon may be possible when it can be described by a sparse set of basis functions. In this paper, we show how to apply compressive sampling techniques to the recording, analysis and synthesis of spatially extended sound fields. Numerical simulations demonstrate that our proposed method can dramatically improve the playback of spatialised sound fields as compared, for example, with High Order Ambisonics.
Melanoma Cells Revive an Embryonic Transcriptional Network to Dictate Phenotypic Heterogeneity

Compared to the overwhelming amount of literature describing how epithelial-to-mesenchymal transition (EMT)-inducing transcription factors orchestrate cellular plasticity in embryogenesis and epithelial cells, the functions of these factors in non-epithelial contexts, such as melanoma, are less clear. Melanoma is an aggressive tumor arising from melanocytes, endowed with unique features of cellular plasticity. The reversible phenotype-switching between differentiated and invasive phenotypes is increasingly appreciated as a mechanism accounting for heterogeneity in melanoma and is driven by oncogenic signaling and environmental cues. This phenotypic switch is coupled with an intriguing and somewhat counterintuitive signaling switch of EMT-inducing transcription factors. In contrast to carcinomas, different EMT-inducing transcription factors have antagonizing effects in melanoma. Balancing between these different EMT transcription factors is likely the key to successful metastatic spread of melanoma.
Effect of Concomitant Consumption of Fish Oil and Vitamin E on T Cell Mediated Function in the Elderly: A Randomized Double-Blind Trial

Objectives: To determine if concomitant consumption of fish oil and vitamin E would modify the vitamin E level needed for improving T cell mediated function in elderly. Methods: A randomized and double-blind study was conducted using 40 healthy male and female elderly subjects (>65 y) who were randomly assigned to one of 4 groups (n = 10/group). All the subjects received 5 g of fish oil daily containing 1.5 g eicosapentaenoic acid (EPA) and 1 g docosahexaenoic acid (DHA), and a capsule containing different doses of dl-α-tocopherol (0, 100, 200 or 400 mg/day) for 3 mo. Plasma vitamin E and fatty acid levels, and in vivo [delayed-type hypersensitivity skin response (DTH) and T cell sub-population analysis] and ex vivo [mitogen-stimulated peripheral blood mononuclear cells (PBMC) proliferation and interleukin (IL)-2 production] immune functions were determined at baseline and after supplementation. Results: The control group (fish oil only) did not show a statistically significant change in either DTH or PBMC proliferation. DTH response, however, was significantly increased from baseline in all groups supplemented with fish oil plus vitamin E and a significant positive correlation between DTH response and plasma concentrations of α-tocopherol was observed. PBMC proliferation was only significantly increased in the group supplemented with fish oil plus 200 mg vitamin E. However, the changes caused by fish oil plus vitamin E in either DTH or PBMC proliferation were not significantly different from those observed in control group. Plasma levels of α-tocopherol were significantly increased in all three fish oil plus vitamin E groups and the increase in plasma α-tocopherol level was less profound than that previously reported when vitamin E was given alone. Conclusions: The immuno-enhancing effect of vitamin E in the elderly is dampened when it is concomitantly consumed with fish oil. This may be due to the smaller increase in plasma concentrations of vitamin E in the presence of fish oil.
Tracking adenovirus genomes identifies morphologically distinct late DNA replication compartments

In adenoviral virions, the genome is organized into a chromatin‐like structure by viral basic core proteins. Consequently viral DNAs must be replicated, chromatinized and packed into progeny virions in infected cells. Although viral DNA replication centers can be visualized by virtue of viral and cellular factors, the spatiotemporal regulation of viral genomes during subsequent steps remains to be elucidated. In this study, we used imaging analyses to examine the fate of adenoviral genomes and to track newly replicated viral DNA as well as replication‐related factors. We show de novo formation of a subnuclear domain, which we termed Virus‐induced Post‐Replication (ViPR) body, that emerges concomitantly with or immediately after disintegration of initial replication centers. Using a nucleoside analogue, we show that viral genomes continue being synthesized in morphologically distinct replication compartments at the periphery of ViPR bodies and are then transported inward. In addition, we identified a nucleolar protein Mybbp1a as a molecular marker for ViPR bodies, which specifically associated with viral core protein VII. In conclusion, our work demonstrates the formation of previously uncharacterized viral DNA replication compartments specific for late phases of infection that produce progeny viral genomes accumulating in ViPR bodies.
LHX2 regulates the neural differentiation of human embryonic stem cells via transcriptional modulation of PAX6 and CER1

The LIM homeobox 2 transcription factor Lhx2 is known to control crucial aspects of neural development in various species. However, its function in human neural development is still elusive. Here, we demonstrate that LHX2 plays a critical role in human neural differentiation, using human embryonic stem cells (hESCs) as a model. In hESC-derived neural progenitors (hESC-NPs), LHX2 was found to be expressed before PAX6, and co-expressed with early neural markers. Conditional ectopic expression of LHX2 promoted neural differentiation, whereas disruption of LHX2 expression in hESCs significantly impaired neural differentiation. Furthermore, we have demonstrated that LHX2 regulates neural differentiation at two levels: first, it promotes expression of PAX6 by binding to its active enhancers, and second, it attenuates BMP and WNT signaling by promoting expression of the BMP and WNT antagonist Cerberus 1 gene (CER1), to inhibit non-neural differentiation. These findings indicate that LHX2 regulates the transcription of downstream intrinsic and extrinsic molecules that are essential for early neural differentiation in human.
On the role of head motion in affective expression

Non-verbal behavioral cues, such as head movement, play a significant role in human communication and affective expression. Although facial expression and gestures have been extensively studied in the context of emotion understanding, the head motion (which accompany both) is relatively less understood. This paper studies the significance of head movement in adult's affect communication using videos from movies. These videos are taken from the Acted Facial Expression in the Wild (AFEW) database and are labeled with seven basic emotion categories: anger, disgust, fear, joy, neutral, sadness, and surprise. Considering human head as a rigid body, we estimate the head pose at each video frame in terms of the three Euler angles, and obtain a time-series representation of head motion. First, we investigate the importance of the energy of angular head motion dynamics (displacement, velocity and acceleration) in discriminating among emotions. Next, we analyze the temporal variation of head motion by fitting an autoregressive model to the head motion time series. We observe that head motion carries sufficient information to distinguish any emotion from the rest with high accuracy and this information is complementary to that of facial expression as it helps improve emotion recognition accuracy.
Intravenous Autologous Bone Marrow Mononuclear Stem Cell Therapy for Ischemic Stroke: A Multicentric, Randomized Trial

Background and Purpose— Pilot studies have suggested benefit from intravenous administration of bone marrow mononuclear stem cells (BMSCs) in stroke. We explored the efficacy and safety of autologous BMSCs in subacute ischemic stroke. Methods— This was a phase II, multicenter, parallel group, randomized trial with blinded outcome assessment that included 120 patients. Patients with subacute ischemic stroke were randomly assigned to the arm that received intravenous infusion of autologous BMSCs or to control arm. Coprimary clinical efficacy outcomes were Barthel Index score and modified Rankin scale at day 180. Secondary outcomes were change in infarct volume, National Institute of Health Stroke Scale (NIHSS) at day 90 and 180. Main safety outcomes were adverse events, any new area of 18fluorodeoxyglucose positron emission tomography uptake in any body part over 365 days. Results— Fifty-eight patients received a mean of 280.75 million BMSCs at median of 18.5 days after stroke onset. There was no significant difference between BMSCs arm and control arm in the Barthel Index score (63.1 versus 63.6; P=0.92), modified Rankin scale shift analysis (P=0.53) or score >3 (47.5% versus 49.2%; P=0.85), NIHSS score (6.3 versus 7.0; P=0.53), change in infarct volume (−11.1 versus −7.36; P=0.63) at day 180. Adverse events were also similar in the 2 arms, and no patient showed any new area of 18fluorodeoxyglucose uptake. Conclusions— With the methods used, results of this hitherto first randomized controlled trial indicate that intravenous infusion of BMSCs is safe, but there is no beneficial effect of treatment on stroke outcome. Clinical Trial Registration— URLs: http://ctri.nic. in/Clinicaltrials and http://www.clinicaltrials. gov. Unique identifiers: CTRI-ROVCTRI/2008/091/0004 and NCT0150177.
Primary monophasic synovial sarcoma lung with brain metastasis diagnosed on transthoracic FNAC: Report of a case with literature review

Synovial sarcoma is highly malignant tumor of soft tissues, occurring chiefly in the extremities and limb girdle with a propensity for local recurrence and sometimes metastases to the lungs. Primary synovial sarcoma arising in the lungs is rare and brain metastasis as presentation is further uncommon. We report a case of primary monophasic synovial sarcoma lung presenting with brain metastasis in a 35-year-old male patient. The diagnosis was made on percutaneous transthoracic needle aspiration from left-sided pulmonary mass and later confirmed by immunohistochemistry. The utility of preoperative diagnosis by percutaneous aspiration cytology is also stressed.
Predicting Intraday Stock returns by Integrating Market Data and Financial News Reports

Forecasting in the financial domain is undoubtedly a challenging undertaking in data mining. While the majority of previous studies in this field utilize historical market data to predict future stock returns, we explore whether there is benefit in augmenting the prediction model with supplementary domain knowledge obtained from financial news reports. To this end, we empirically evaluate how the integration of these data sources helps to predict intraday stocks returns. We consider several types of integration methods: variable-based as well as bundling methods. To discern whether the integration methods are sensitive to the type of forecasting algorithm, we have implemented each integration method using three different data mining algorithms. The results show several scenarios in which appending market-based data with textual news-based data helps to improve forecasting performance. The successful integration strongly depends on which forecasting algorithm and variable representation method is utilized. The findings are promising enough to warrant further studies in this direction.
The neural basis of understanding the expression of the emotions in man and animals

Abstract Humans cannot help but attribute human emotions to non-human animals. Although such attributions are often regarded as gratuitous anthropomorphisms and held apart from the attributions humans make about each other’s internal states, they may be the product of a general mechanism for flexibly interpreting adaptive behavior. To examine this, we used functional magnetic resonance imaging (fMRI) in humans to compare the neural mechanisms associated with attributing emotions to humans and non-human animal behavior. Although undergoing fMRI, participants first passively observed the facial displays of human, non-human primate and domestic dogs, and subsequently judged the acceptability of emotional (e.g. ‘annoyed’) and facial descriptions (e.g. ‘baring teeth’) for the same images. For all targets, emotion attributions selectively activated regions in prefrontal and anterior temporal cortices associated with causal explanation in prior studies. These regions were similarly activated by both human and non-human targets even during the passive observation task; moreover, the degree of neural similarity was dependent on participants’ self-reported beliefs in the mental capacities of non-human animals. These results encourage a non-anthropocentric view of emotion understanding, one that treats the idea that animals have emotions as no more gratuitous than the idea that humans other than ourselves do.
Blood Fibrinolytic Activity in Man: Diurnal Variation and the Response to Varying Intensities of Exercise

This investigation was undertaken in normal subjects to define the relationship between the intensity of exercise and magnitude of fibrinolytic response and to examine the effect of diurnal variations on the exercise response. Fibrinolytic activity was measured on fibrin plates and expressed as mm2. Diurnal variations occurred with lowest activity at 8:00 AM (mean, 66 mm2), and peak activity between 5:00 and 8:00 PM (mean, 266 mm2, P<0.001). Five minutes of maximal treadmill exercise caused a marked increase in mean activity from 90 to 658 mm2 (P<0.001). Five minutes of 70% maximal exercise produced no significant increase, but 30 minutes increased activity to 626 mm2 (P<0.005). In contrast, 30 minutes of 40% maximal exercise produced a small elevation from 80 to 173 mm2 (P<0.005). Maximal and 40% maximal exercise evoked greater responses at 4:00 PM than 8:00 AM. Exercise produces increases in fibrinolytic activity which are related to the relative intensity of exercise, its duration, and the time of day it is performed. Short bursts of intense exercise cause marked increases, but more prolonged bouts of moderate exercise are required to produce similar increases. The increases with prolonged mild exercise are small and comparable to those observed during resting diurnal variations.