Miracle-dz/UniFAR-FTUs huggingface dataset:
Common and Distinct Impacts of Autistic Traits and Alexithymia on Social Reward

According to the social motivation hypothesis of autism, individuals with high levels of autistic traits experience reduced levels of reward from social interactions. However, empirical evidence to date has been mixed, with some studies reporting lower levels of social reward in individuals with Autism Spectrum Disorder (ASD), and others finding no difference when compared to typically developing controls. Alexithymia, a subclinical condition associated with the reduced ability to identify and describe one’s own emotions, has been found to account for other affective difficulties observed inconsistently in individuals with ASD. The current study used a nonclinical sample (N = 472) to explore the associations between autistic traits and the value of six types of social reward, as measured by the Social Reward Questionnaire. In addition, we measured alexithymia to assess if this accounted for associations between autistic traits and social reward. There were three main findings. Firstly, higher levels of autistic traits were associated with significantly less enjoyment of admiration and sociability, and adding alexithymia to these models did not account for any additional variance. Secondly, both autistic traits and alexithymia were uniquely associated with reduced levels of enjoyment of prosocial interactions and sexual relationships. Thirdly, autistic traits were associated with higher levels of enjoyment of passivity and negative social potency, but these associations were no longer significant once alexithymia was taken into account, suggesting that co-occurring alexithymia accounted for these apparent associations. Overall, the current findings provide a novel and more nuanced picture of the relationship between autistic traits and social reward.
Nearly Doubling the Throughput of Multiuser MIMO Systems Using Codebook Tailored Limited Feedback Protocol

We present and analyze a new robust feedback and transmit strategy for multiuser MIMO downlink communication systems, termed Rate Approximation (RA). RA combines the flexibility and robustness needed for reliable communications with the user terminal under a limited feedback constraint. It responds to two important observations. First, it is not so significant to approximate the channel but rather the rate, such that the optimal scheduling decision can be mimicked at the base station. Second, a fixed transmit codebook at the transmitter is often better when therefore the channel state information is more accurate. In the RA scheme the transmit and feedback codebook are separated and user rates are delivered to the base station subject to a controlled uniform error. The scheme is analyzed and proved to have better performance below a certain interference plus noise margin and better behavior than the classical Jindal formula. LTE system simulations sustain the analytic results showing performance gains of up to 50% or 70% compared to zeroforcing when using multiple antennas at the base station and multiple antennas or a single antenna at the terminals, respectively. A new feedback protocol is developed which inherently considers the transmit codebook and which is able to deal with the complexity issue at the terminal.
The Effect of Recurrent Floods on Genetic Composition of Marble Trout Populations

A changing global climate can threaten the diversity of species and ecosystems. We explore the consequences of catastrophic disturbances in determining the evolutionary and demographic histories of secluded marble trout populations in Slovenian streams subjected to weather extremes, in particular recurrent flash floods and debris flows causing massive mortalities. Using microsatellite data, a pattern of extreme genetic differentiation was found among populations (global F ST of 0.716), which exceeds the highest values reported in freshwater fish. All locations showed low levels of genetic diversity as evidenced by low heterozygosities and a mean of only 2 alleles per locus, with few or no rare alleles. Many loci showed a discontinuous allele distribution, with missing alleles across the allele size range, suggestive of a population contraction. Accordingly, bottleneck episodes were inferred for all samples with a reduction in population size of 3–4 orders of magnitude. The reduced level of genetic diversity observed in all populations implies a strong impact of genetic drift, and suggests that along with limited gene flow, genetic differentiation might have been exacerbated by recurrent mortalities likely caused by flash flood and debris flows. Due to its low evolutionary potential the species might fail to cope with an intensification and altered frequency of flash flood events predicted to occur with climate change.
An algorithm for Web service discovery through their composition

The Web services stack of standards is designed to support the reuse and the interoperation of software components on the Web. A critical step in the process of developing applications based on the service oriented architecture is the service discovery. This paper shows how service composition can be used as a technique to support service discovery. The paper discusses the current state of research in this area and introduces a semantic matching algorithm that exploits the possibility to compose multiple services in order to satisfy a service request.
Validation of global moderate-resolution LAI products: a framework proposed within the CEOS land product validation subgroup

Initiated in 1984, the Committee Earth Observing Satellites' Working Group on Calibration and Validation (CEOS WGCV) pursues activities to coordinate, standardize and advance calibration and validation of civilian satellites and their data. One subgroup of CEOS WGCV, Land Product Validation (LPV), was established in 2000 to define standard validation guidelines and protocols and to foster data and information exchange relevant to the validation of land products. Since then, a number of leaf area index (LAI) products have become available to the science community at both global and regional extents. Having multiple global LAI products and multiple, disparate validation activities related to these products presents the opportunity to realize efficiency through international collaboration. So the LPV subgroup established an international LAI intercomparison validation activity. This paper describes the main components of this international validation effort. The paper documents the current participants, their ground LAI measurements and scaling techniques, and the metadata and infrastructure established to share data. The paper concludes by describing plans for sharing both field data and high-resolution LAI products from each site. Many considerations of this global LAI intercomparison can apply to other products, and this paper presents a framework for such collaboration
Evolution from electrophysiologic to hemodynamic monitoring: the story of left atrial and pulmonary artery pressure monitors

Heart failure (HF) is a costly, challenging and highly prevalent medical condition. Hospitalization for acute decompensation is associated with high morbidity and mortality. Despite application of evidence-based medical therapies and technologies, HF remains a formidable challenge for virtually all healthcare systems. Repeat hospitalizations for acute decompensated HF (ADHF) can have major financial impact on institutions and resources. Early and accurate identification of impending ADHF is of paramount importance yet there is limited high quality evidence or infrastructure to guide management in the outpatient setting. Historically, ADHF was identified by physical exam findings or invasive hemodynamic monitoring during a hospital admission; however, advances in medical microelectronics and the advent of device-based diagnostics have enabled long-term ambulatory monitoring of HF patients in the outpatient setting. These monitors have evolved from piggybacking on cardiac implantable electrophysiologic devices to standalone implantable hemodynamic monitors that transduce left atrial or pulmonary artery pressures as surrogate measures of left ventricular filling pressure. As technology evolves, devices will likely continue to miniaturize while their capabilities grow. An important, persistent challenge that remains is developing systems to translate the large volumes of real-time data, particularly data trends, into actionable information that leads to appropriate, safe and timely interventions without overwhelming outpatient cardiology and general medical practices. Future directions for implantable hemodynamic monitors beyond their utility in heart failure may include management of other major chronic diseases such as pulmonary hypertension, end stage renal disease and portal hypertension.
L‐type Ca2+ channel and ryanodine receptor cross‐talk in frog skeletal muscle

The dihydropyridine receptors (DHPRs)/L‐type Ca2+ channels of skeletal muscle are coupled with ryanodine receptors/Ca2+ release channels (RyRs/CRCs) located in the sarcoplasmic reticulum (SR). The DHPR is the voltage sensor for excitation–contraction (EC) coupling and the charge movement component qγ has been implicated as the signal linking DHPR voltage sensing to Ca2+ release from the coupled RyR. Recently, a new charge component, qh, has been described and related to L‐type Ca2+ channel gating. Evidence has also been provided that the coupled RyR/CRC can modulate DHPR functions via a retrograde signal. Our aim was to investigate whether the newly described qh is also involved in the reciprocal interaction or cross‐talk between DHPR/L‐type Ca2+ channel and RyR/CRC. To this end we interfered with DHPR/L‐type Ca2+ channel function using nifedipine and 1‐alkanols (heptanol and octanol), and with RyR/CRC function using ryanodine and ruthenium red (RR). Intramembrane charge movement (ICM) and L‐type Ca2+ current (ICa) were measured in single cut fibres of the frog using the double‐Vaseline‐gap technique. Our records showed that nifedipine reduced the amount of qγ and qh moved by ∼90% and ∼55%, respectively, whereas 1‐alkanols completely abolished them. Ryanodine and RR shifted the transition voltages of qγ and qh and of the maximal conductance of ICa by ∼4−9 mV towards positive potentials. All these interventions spared qβ. These results support the hypothesis that only qγ; and qh arise from the movement of charged particles within the DHPR/L‐type Ca2+ channel and that these charge components together with ICa are affected by a retrograde signal from RyR/CRC.
Relationship assessment for freshwater phytoplankton and a water quality index during dry and wet season in a free water surface constructed wetland in Malaysia

The aim of this study is to understand the distribution of phytoplankton to assess the performance of a free water surface (FWS) constructed wetland based on the water quality index (WQI) evaluation. The constructed wetland consists of three main zone; forebay zone, macrophytes zone and micropool zone. The highest WQI value was obtained in the micropool zone with the range of 78.98-85.45 (82.71 +- 3.35), while the lowest WQI value was obtained in the macrophytes zone with the range of 68.13-77.96 (73.25 +- 3.42). The higher distribution of phytoplankton was obtained in the macrophytes zone due to the high nutrient concentrations available. The dry season showed higher concentration of the nutrient, ammoniacal nitrogen, compared to the wet season. The distribution of phytoplankton was high during the dry season compared to the wet season. Phytoplankton distribution is closely related to dissolve oxygen, water temperature and WQI value in the FWS constructed wetland.
Local norms of cheating and the cultural evolution of crime and punishment: a study of two urban neighborhoods

The prevalence of antisocial behavior varies across time and place. The likelihood of committing such behavior is affected by, and also affects, the local social environment. To further our understanding of this dynamic process, we conducted two studies of antisocial behavior, punishment, and social norms. These studies took place in two neighborhoods in Newcastle Upon Tyne, England. According to a previous study, Neighborhood A enjoys relatively low frequencies of antisocial behavior and crime and high levels of social capital. In contrast, Neighborhood B is characterized by relatively high frequencies of antisocial behavior and crime and low levels of social capital. In Study 1, we used an economic game to assess neighborhood differences in theft, third-party punishment (3PP) of theft, and expectation of 3PP. Participants also reported their perceived neighborhood frequency of cooperative norm violation (“cheating”). Participants in Neighborhood B thought that their neighbors commonly cheat but did not condone cheating. They stole more money from their neighbors in the game, and were less punitive of those who did, than the residents of Neighborhood A. Perceived cheating was positively associated with theft, negatively associated with the expectation of 3PP, and central to the neighborhood difference. Lower trust in one’s neighbors and a greater subjective value of the monetary cost of punishment contributed to the reduced punishment observed in Neighborhood B. In Study 2, we examined the causality of cooperative norm violation on expectation of 3PP with a norms manipulation. Residents in Neighborhood B who were informed that cheating is locally uncommon were more expectant of 3PP. In sum, our results provide support for three potentially simultaneous positive feedback mechanisms by which the perception that others are behaving antisocially can lead to further antisocial behavior: (1) motivation to avoid being suckered, (2) decreased punishment of antisocial behavior, and (3) decreased expectation of punishment of antisocial behavior. Consideration of these mechanisms and of norm psychology will help us to understand how neighborhoods can descend into an antisocial culture and get stuck there.
Channel Estimation and Equalization for Cooperative Communication

ii I hereby declare that I am the sole author of this thesis. This is a true copy of the thesis, including any required final revisions, as accepted by my examiners. I understand that my thesis may be made electronically available to the public. Abstract The revolutionary concept of space-time coding introduced in the last decade has demonstrated that the deployment of multiple antennas at the transmitter allows for simultaneous increase in throughput and reliability because of the additional degrees of freedom offered by the spatial dimension of the wireless channel. However, the use of antenna arrays is not practical for deployment in some practical scenarios, e.g., sensor networks, due to space and power limitations. A new form of realizing transmit diversity has been recently introduced under the name of user cooperation or cooperative diversity. The basic idea behind cooperative diversity rests on the observation that in a wireless environment, the signal transmitted by the source node is overheard by other nodes, which can be defined as " partners " or " relays ". The source and its partners can jointly process and transmit their information, creating a " virtual antenna array " and therefore emulating transmit diversity. Most of the ongoing research efforts in cooperative diversity assume frequency flat channels with perfect channel knowledge. However, in practical scenarios, e.g. broadband wireless networks, these assumptions do not apply. Frequency-selective fading and imperfect channel knowledge should be considered as a more realistic channel model. The development of equalization and channel estimation algorithms play a crucial element in the design of digital receivers as their accuracy determine the overall performance. This dissertation creates a framework for designing and analyzing various time and frequency domain equalization schemes, i.e. distributed time reversal (D-TR) STBC, distributed single carrier frequency domain (D-SC-FDE) STBC, and distributed orthogonal frequency division multiplexing (D-OFDM) STBC schemes, for broadband cooperative communication systems. Exploiting the orthogonally embedded in D-STBCs, we were able iv to maintain low-decoding complexity for all underlying schemes, thus, making them excellent candidates for practical scenarios, such as multi-media broadband communication systems. Furthermore, we propose and analyze various non-coherent and channel estimation algorithms to improve the quality and reliability of wireless communication networks. Specifically, we derive a non-coherent decoding rule which can be implemented in practice by a Viterbi-type algorithm. We demonstrate through the derivation of a pairwise error probability expression that the proposed non-coherent detector guarantees full diversity. …
Overexpression of miR-125a in Myelodysplastic Syndrome CD34+ Cells Modulates NF-κB Activation and Enhances Erythroid Differentiation Arrest

Myelodysplastic syndromes (MDS) are characterized by impaired proliferation and differentiation of hematopoietic stem cells. The participation of toll-like receptor (TLR)-mediated signaling in MDS is well documented. Increased TLR signaling leads to the constitutive activation of NF-κB, which mediates inflammation, cell proliferation and apoptosis. In addition, the TLR pathway induces the expression of miRNAs which participate in the fine-tuning of the inflammatory response. miRNAs also regulate other biological processes, including hematopoiesis. miR-125a and miR-125b are known modulators of hematopoiesis and are abnormally expressed in several hematologic malignancies. However, little is known about their role in MDS. NF-κB-activating ability has been described for both miRNAs. We studied the role of miR-125a/miR-125b in MDS and their relationship with TLR signaling and hematopoietic differentiation. Our results indicate that miR-125a is significantly overexpressed in MDS patients and correlates negatively with patient survival. Expression of miR-99b, which is clustered with miR-125a, is also directly correlated with prognosis of MDS. Both miR-125a and miR-99b activated NF-κB in vitro; however, we observed a negative correlation between miR-99b expression and the levels of TLR2, TLR7 and two downstream genes, suggesting that NF-κB activation by the miRNA cluster occurs in the absence of TLR signaling. We also show that TLR7 is negatively correlated with patient survival in MDS. In addition, our data suggest that miR-125a may act as an NF-κB inhibitor upon TLR stimulation. These results indicate that miR-125a is involved in the fine-tuning of NF-κB activity and that its effects may depend on the status of the TLR pathway. Furthermore, we observed that miR-125a inhibits erythroid differentiation in leukemia and MDS cell lines. Therefore, this miRNA could serve as a prognostic marker and a potential therapeutic target in MDS.
When Do Research Consortia Work Well and Why? Evidence from Japanese Panel Data

We examine the impact of a large number of Japanese government-sponsored research consortia on the research productivity of participating firms by measuring their patenting in the targeted technologies before, during, and after participation. Consistent with the theoretical predictions of Katz (1986) and others, we find consortium outcomes are positively associated with the level of potential R&D spillovers within the consortium and (weakly) negatively associated with the degree of product market competition among consortium members. Furthermore, our evidence suggests that consortia are most effective when they focus on basic research.
Herpes Zoster Among Persons Living With HIV in the Current Antiretroviral Therapy Era

Background:Previously, herpes zoster (HZ) was found to occur at a higher rate in the HIV population than the general population. However, there are limited data about the incidence, risk factors, and clinical outcomes of HZ in the current antiretroviral therapy (ART) era. Methods:We identified HZ episodes in an urban HIV clinic cohort between 2002 and 2009. Three controls were matched to each case, and conditional logistic regression was used to assess for risk factors associated with incident HZ cases. Logistic regression was used to assess for factors associated with complicated HZ. Results:One hundred eighty-three new HZ cases were identified in 4353 patients with 19,752 person-years (PY) of follow-up—an incidence rate 9.3/1000 PY. Cases were majority men (62%) and African American (75%), with a mean age of 39 years (interquartile range, 32–44 years). Fifty patients (28%) had complicated HZ with 12% developing postherpetic neuralgia. In multivariate regression, factors associated with the increased risk of HZ were having started ART within 90 days of the episode [adjusted odds ratio (AOR), 4.02; 95% confidence interval (CI), 1.31 to 12.41], having a viral load of >400 copies per milliliter (AOR, 1.49; 95% CI, 1.00 to 2.24), and having a CD4 <350 cells per cubic millimeter (AOR, 2.46; 95% CI, 1.42 to 4.23) or 350 to 500 cells per cubic millimeter (AOR, 2.02; 95% CI, 1.14 to 3.57) as compared with CD4 >500 cells per cubic millimeter. Conclusions:The incidence of HZ is lower than previously reported in HIV cohorts but remains higher than the general population. Over one fourth of patients developed complicated HZ, which is remarkable given the young age of our population. Risk factors for HZ include markers of poor immune function, suggesting that appropriate ART may reduce the burden of HZ in this population.
Carbon- and nitrogen-quality signaling to translation are mediated by distinct GATA-type transcription factors

The target of rapamycin (Tor) proteins sense nutrients and control transcription and translation relevant to cell growth. Treating cells with the immunosuppressant rapamycin leads to the intracellular formation of an Fpr1p-rapamycin-Tor ternary complex that in turn leads to translational down-regulation. A more rapid effect is a rich transcriptional response resembling that when cells are shifted from high- to low-quality carbon or nitrogen sources. This transcriptional response is partly mediated by the nutrient-sensitive transcription factors GLN3 and NIL1 (also named GAT1). Here, we show that these GATA-type transcription factors control transcriptional responses that mediate translation by several means. Four observations highlight upstream roles of GATA-type transcription factors in translation. In their absence, processes caused by rapamycin or poor nutrients are diminished: translation repression, eIF4G protein loss, transcriptional down-regulation of proteins involved in translation, and RNA polymerase I/III activity repression. The Tor proteins preferentially use Gln3p or Nil1p to down-regulate translation in response to low-quality nitrogen or carbon, respectively. Functional consideration of the genes regulated by Gln3p or Nil1p reveals the logic of this differential regulation. Besides integrating control of transcription and translation, these transcription factors constitute branches downstream of the multichannel Tor proteins that can be selectively modulated in response to distinct (carbon- and nitrogen-based) nutrient signals from the environment.
Review of microleakage evaluation tools

The advancement of restorative materials and techniques continues to enhance the clinical success of numerous restorative procedures. Despite these new innovations, microleakage persists as one of the main causes of restoration failure. Microleakage tests provide useful information on the performance of restorative materials, and different techniques for assessing microleakage have been developed and used. These tests include the use of dyes, radioactive isotopes, air pressure, bacteria, neutron activation analysis, and artificial caries. However, little has been done to determine the cause, mechanism, and nature of microleakage. Therefore, this review outlines and discusses the currently available microleakage assessment tools.