Miracle-dz/UniFAR-FTUs huggingface dataset:
A Clinical Evaluation of the Competing Sources of Input Hypothesis.

Purpose Our purpose was to test the competing sources of input (CSI) hypothesis by evaluating an intervention based on its principles. This hypothesis proposes that children's use of main verbs without tense is the result of their treating certain sentence types in the input (e.g., Wasshe laughing? ) as models for declaratives (e.g., She laughing). Method Twenty preschoolers with specific language impairment were randomly assigned to receive either a CSI-based intervention or a more traditional intervention that lacked the novel CSI features. The auxiliary is and the third-person singular suffix -s were directly treated over a 16-week period. Past tense -ed was monitored as a control. Results The CSI-based group exhibited greater improvements in use of is than did the traditional group (d = 1.31), providing strong support for the CSI hypothesis. There were no significant between-groups differences in the production of the third-person singular suffix -s or the control (-ed), however. Conclusions The group differences in the effects on the 2 treated morphemes may be due to differences in their distribution in interrogatives and declaratives (e.g., Ishe hiding/Heishiding vs. Doeshe hide/He hides). Refinements in the intervention could address this issue and lead to more general effects across morphemes.
The secondary spiral lamina and its relevance in cochlear implant surgery

Abstract Objective: We used synchrotron radiation phase contrast imaging (SR-PCI) to study the 3D microanatomy of the basilar membrane (BM) and its attachment to the spiral ligament (SL) (with a conceivable secondary spiral lamina [SSL] or secondary spiral plate) at the round window membrane (RWM) in the human cochlea. The conception of this complex anatomy may be essential for accomplishing structural preservation at cochlear implant surgery. Material and methods: Sixteen freshly fixed human temporal bones were used to reproduce the BM, SL, primary and secondary osseous spiral laminae (OSL), and RWM using volume-rendering software. Confocal microscopy immunohistochemistry (IHC) was performed to analyze the molecular constituents. Results: SR-PCI reproduced the soft tissues including the RWM, Reissner’s membrane (RM), and the BM attachment to the lateral wall (LW) in three dimensions. A variable SR-PCI contrast enhancement was recognized in the caudal part of the SL facing the scala tympani (ST). It seemed to represent a SSL allied to the basilar crest (BC). The SSL extended along the postero-superior margin of the round window (RW) and immunohistochemically expressed type II collagen. Conclusions: Unlike in several mammalian species, the human SSL is restricted to the most basal portion of the cochlea around the RW. It anchors the BM and may influence its hydro-mechanical properties. It could also help to shield the BM from the RW. The microanatomy should be considered at cochlear implant surgery.
Fabric-Evoked Prickle in Worsted Spun Single Jersey Fabrics Part II: The Role of Fiber Length, Yarn Count, and Fabric Cover Factor

Fabric-evoked prickle is studied in a range of jersey knitted wool fabrics made from worsted spun yarn. The existing predictive model of relative prickliness based on earlier studies of wools with diameter characteristics is extended and can quantitatively account for changes in mean fiber length, yarn count, and fabric cover factor. For all these variables, relative prickle sensation can be predicted from the density of coarse fiber ends per unit area of fabric. It is thus possible to compare the relative importance of these variables. Within the commercial range, the mean fiber diameter of a wool remains the most important factor affecting fabric-evoked prickle.
Factors Associated with Willingness to Accept Oral Fluid HIV Rapid Testing among Most-at-Risk Populations in China

Background The availability of oral fluid HIV rapid testing provides an approach that may have the potential to expand HIV testing in China, especially among most-a-risk populations. There are few investigations about the acceptability of oral fluid HIV testing among most-at-risk populations in China. Method A cross-sectional study with men who have sex with men (MSM), female sex workers (FSW) and voluntary counseling and testing (VCT) clients was conducted in three cities of Shandong province, China from 2011 to 2012. Data were collected by face-to-face questionnaire. Results About 71% of participants were willing to accept the oral fluid HIV rapid testing, and home HIV testing was independently associated with acceptability of the new testing method among MSM, FSW and VCT clients (AOR of 4.46, 3.19 and 5.74, respectively). Independent predictors of oral fluid HIV rapid testing acceptability among MSM were having ever taken an oral fluid HIV rapid test (AOR= 15.25), having ever taken an HIV test (AOR= 2.07), and education level (AOR= 1.74). Engagement in HIV-related risk behaviors (AOR= 1.68) was an independent predictor of acceptability for FSW. Having taken an HIV test (AOR= 2.85) was an independent predictor of acceptability for VCT clients. The primary concern about the oral fluid HIV testing was accuracy. The median price they would pay for the testing ranged from 4.8 to 8.1 U.S. dollars. Conclusion High acceptability of oral fluid HIV rapid testing was shown among most-at-risk populations. Findings provide support for oral rapid HIV testing as another HIV prevention tool, and provide a backdrop for the implementation of HIV home testing in the near future. Appropriate pricing and increased public education through awareness campaigns that address concerns about the accuracy and safety of the oral fluid HIV rapid testing may help increase acceptability and use among most-at-risk populations in China.
Dysregulation of GdA Expression in Endometrium of Women With Endometriosis: Implication for Endometrial Receptivity

Glycodelin-A (GdA) has been proposed to represent a potential biomarker of endometrial function, but little is known about its expression during the different phases of the menstrual cycle and under pathological conditions. In the light of its potential importance also in embryo implantation, we aimed to evaluate the expression profile of GdA as well as the presence of different glycosylated glycoforms and the immunolocalization in endometrial tissue from women with endometriosis and in women with proven fertility, at different times during the menstrual cycle. Our results showed that GdA is synthesized by endometrial epithelial and stromal cells, both in healthy endometrium and eutopic endometrium from women with endometriosis, with a profile including several glycosylated glycoforms, differentially expressed in each phase of the menstrual cycle. During the secretory phase, a significant increase in GdA protein expression, with a different glycoforms profile, was observed in endometriotic eutopic endometrium. Protein localization in eutopic endometrial tissue resulted significantly different in comparison with endometrium from women with proven fertility. This study indicate that GdA is a complex glycoprotein including up to 6 different glycoforms specifically expressed during the different phase of the menstrual cycle; in pathologic conditions such as endometriosis, the expression profile is altered possibly related to the impaired endometrial receptivity.
Fast Training of Multi-Class Support Vector Machines

We present new decomposition algorithms for training multi-class support vector machines (SVMs), in particular the variants proposed by Lee, Lin, & Wahba (LLW) and Weston & Watkins (WW). Although these two types of machines have desirable theoretical properties, they have been rarely used in practice because ecient train- ing algorithms have been missing. Training is accelerated by considering hypotheses without bias, by second order working set selection, and by using working sets of size two instead of applying sequential minimal optimization (SMO). We derive a new bound for the generalization performance of multi-class SVMs. The bound de- pends on the sum of target margin violations, which corresponds to the loss function employed in the WW machine. The improved training scheme allows us to perform a thorough empirical comparison of the Crammer & Singer (CS), the WW, and the LLW machine. In our experiments, all machines gave better generalization results than the baseline one-vs-all approach. The two-variable decomposition algorithm outperformed SMO. The LLW SVM performed best in terms of accuracy, at the cost of slower training. The WW SVM led to better generalizing hypotheses compared to the CS machine and did not require longer training times. Thus, we see no reason to prefer the CS variant over the WW SVM.
Locating relevant source files for bug reports using textual analysis

Bug reports are an important part of software project's life cycle since they help improve the software's quality. However, in well-known systems, the huge number of bug reports make it difficult for the developer team to efficiently locate the bug and then assign it to be fixed. To solve this issue, various bug localization techniques have been proposed to rank all the source files of a project with respect to how likely they are to contain a bug. This makes the source files' search space smaller and helps developers to find relevant source files quicker. In this paper, we propose a three component bug localization approach which leverages different textual properties of bug reports and source files as well as the relations between previously fixed bug reports and a newly received one. Our approach uses information retrieval, textual matching, and multi-label classification to improve the performance of bug localization. We evaluate our approach on two open source software projects (i.e. SWT and ZXing) to examine its performance. Experimental results show that our approach can rank appropriate source files for more than 80% of bugs in top 10 for these projects and also improve the MRR and MAP values compared to two existing bug localization tools, BugLocator and BLUiR.
ar X iv : 1 20 4 . 66 10 v 1 [ cs . L G ] 30 A pr 2 01 2 1 Residual Belief Propagation for Topic Modeling

Fast convergence speed is a desired property for training latent Dirichlet allocation (LDA), especially in online and parallel topic modeling for massive data sets. This paper presents a novel residual belief propagation (RBP) algorithm to accelerate the convergence speed for training LDA. The proposed RBP uses an informed scheduling scheme for asynchronous message passing, which passes fast-convergent messages with a higher priority to influence those slow-convergent messages at each learning iteration. Extensive empirical studies confirm that RBP significantly reduces the training time until convergence while achieves a much lower predictive perplexity than other state-of-the-art training algorithms for LDA, including variational Bayes (VB), collapsed Gibbs sampling (GS), loopy belief propagation (BP), and residual VB (RVB).
A systematic review of the impact of nurse practitioners on cost, quality of care, satisfaction and wait times in the emergency department.

INTRODUCTION US emergency personnel cared for 106% more patients in 1990 than they did in 1980, and national emergency department census data show that 60%-80% of those patients presented with non-urgent or minor medical problems. The hiring of nurse practitioners (NPs) is one proposed solution to the ongoing overcrowding and physician shortage facing emergency departments (EDs). METHODS We conducted a systematic review of MEDLINE and Cinahl to find articles that discussed NPs in the ED setting, looking specifically at 4 key outcome measures: wait times, patient satisfaction, quality of care and cost effectiveness. RESULTS Although some questions remain, a review of the literature suggests that NPs can reduce wait times for the ED, lead to high patient satisfaction and provide a quality of care equal to that of a mid-grade resident. Cost, when compared with resident physicians, is higher; however, data comparing to the hiring additional medical professionals is lacking. CONCLUSION The medical community should further explore the use of NPs, particularly in fast track areas for high volume departments. In rural areas, NPs could supplement overextended physicians and allow health centres to remain open when they might otherwise have to close. These strategies could improve access to care and patient satisfaction for selected urban and rural populations as well as make the best use of limited medical resources.
Cost of Cancer-Related Neutropenia or Fever Hospitalizations, United States, 2012.

PURPOSE Neutropenia and subsequent infections are life-threatening treatment-related toxicities of chemotherapy. Among patients with cancer, hospitalizations related to neutropenic complications result in substantial medical costs, morbidity, and mortality. Previous estimates for the cost of cancer-related neutropenia hospitalizations are based on older and limited data. This study provides nationally representative estimates of the cost of cancer-related neutropenia hospitalizations. METHODS We examined data from the 2012 National Inpatient Sample and Kids' Inpatient Database. Hospitalizations for cancer-related neutropenia were defined as those with a primary or secondary diagnosis of cancer and a diagnosis of neutropenia or a fever of unknown origin. We examined characteristics of cancer-related neutropenia hospitalizations among children (age < 18 years) and adults (age ≥ 18 years). Adjusted predicted margins were used to estimate length of stay and cost per stay. RESULTS There were 91,560 and 16,859 cancer-related neutropenia hospitalizations among adults and children, respectively. Total cost of cancer-related neutropenia hospitalizations was $2.3 billion for adults and $439 million for children. Cancer-related neutropenia hospitalizations accounted for 5.2% of all cancer-related hospitalizations and 8.3% of all cancer-related hospitalization costs. For adults, the mean length of stay for cancer-related neutropenia hospitalizations was 9.6 days, with a mean hospital cost of $24,770 per stay. For children, the mean length of stay for cancer-related neutropenia hospitalizations was 8.5 days, with a mean hospital cost of $26,000 per stay. CONCLUSION We found the costs of cancer-related neutropenia hospitalizations to be substantially high. Efforts to prevent and minimize neutropenia-related complications among patients with cancer may decrease hospitalizations and associated costs.
Transcriptome Comparison Reveals Key Candidate Genes Responsible for the Unusual Reblooming Trait in Tree Peonies

Tree peonies are important ornamental plants worldwide, but growing them can be frustrating due to their short and concentrated flowering period. Certain cultivars exhibit a reblooming trait that provides a valuable alternative for extending the flowering period. However, the genetic control of reblooming in tree peonies is not well understood. In this study, we compared the molecular properties and morphology of reblooming and non-reblooming tree peonies during the floral initiation and developmental processes. Using transcriptome sequencing technology, we generated 59,275 and 63,962 unigenes with a mean size of 698 bp and 699 bp from the two types of tree peonies, respectively, and identified eight differentially expressed genes that are involved in the floral pathways of Arabidopsis thaliana. These differentially regulated genes were verified through a detailed analysis of their expression pattern during the floral process by real time RT-PCR. From this combined analysis, we identified four genes, PsFT, PsVIN3, PsCO and PsGA20OX, which likely play important roles in the regulation of the reblooming process in tree peonies. These data constitute a valuable resource for the discovery of genes involved in flowering time and insights into the molecular mechanism of flowering to further accelerate the breeding of tree peonies and other perennial woody plants.
University of New Hampshire Scholars' Repository University of New Hampshire Scholars' Repository

[ 1 ] Alongshore winds in Baja California strongly influence nearshore temperatures hundreds of kilometers to the north at Point Loma, San Diego, California, on timescales of a week to a year. The time lag between wind and temperature is consistent with first mode coastal trapped wave phase speed. The nearshore cross-shelf circulation forced by the coastal trapped waves is, at least much of the year, oppositely directed at the surface and bottom. No relation is found between the winds and temperature for periods greater than a year. It is argued that similar results may be found elsewhere in the Southern California Bight. The relationship between stratification and bottom temperature varies over the 1.3 years of data, but for much of the time, warmer bottom waters are associated with even warmer surface waters and thus stronger stratification. The effects of the remotely forced cross-shelf exchange on coastal pollution, nutrient dynamics, and larval transport are briefly discussed.
Methods for Population-Adjusted Indirect Comparisons in Health Technology Appraisal

Standard methods for indirect comparisons and network meta-analysis are based on aggregate data, with the key assumption that there is no difference between the trials in the distribution of effect-modifying variables. Methods which relax this assumption are becoming increasingly common for submissions to reimbursement agencies, such as the National Institute for Health and Care Excellence (NICE). These methods use individual patient data from a subset of trials to form population-adjusted indirect comparisons between treatments, in a specific target population. Recently proposed population adjustment methods include the Matching-Adjusted Indirect Comparison (MAIC) and the Simulated Treatment Comparison (STC). Despite increasing popularity, MAIC and STC remain largely untested. Furthermore, there is a lack of clarity about exactly how and when they should be applied in practice, and even whether the results are relevant to the decision problem. There is therefore a real and present risk that the assumptions being made in one submission to a reimbursement agency are fundamentally different to—or even incompatible with—the assumptions being made in another for the same indication. We describe the assumptions required for population-adjusted indirect comparisons, and demonstrate how these may be used to generate comparisons in any given target population. We distinguish between anchored and unanchored comparisons according to whether a common comparator arm is used or not. Unanchored comparisons make much stronger assumptions, which are widely regarded as infeasible. We provide recommendations on how and when population adjustment methods should be used, and the supporting analyses that are required to provide statistically valid, clinically meaningful, transparent and consistent results for the purposes of health technology appraisal. Simulation studies are needed to examine the properties of population adjustment methods and their robustness to breakdown of assumptions.
Chromophobe Renal Cell Carcinoma With Retrograde Venous Invasion and Gain of Chromosome 21: Potential Harbingers of Aggressive Clinical Behavior

Occasionally, renal cell carcinoma (RCC) with renal vein extension spreads against the flow of blood within vein branches into the kidney, forming multifocal nodules throughout the renal parenchyma. These foci are not regarded as multiple tumors but rather reverse spread of tumor along the venous system. This intravascular spread has previously been reported in clear cell RCC and RCC unclassified. However, to our knowledge, this has never been reported in chromophobe RCC. Chromophobe RCC is a unique histologic subtype of renal cancer, generally thought to have less aggressive behavior. However, it nonetheless has the potential to undergo sarcomatoid dedifferentiation, which is associated with poor prognosis. We report a unique case of a 65-year-old man with chromophobe RCC (pT3a) showing classic morphology (nonsarcomatoid), yet presenting with retrograde venous invasion and hilar lymph node metastasis at the time of right radical nephrectomy. Fluorescence in situ hybridization revealed gain of chromosome 21 with loss of multiple other chromosomes. Partial hepatectomy was performed to resect metastatic RCC 7 months after nephrectomy, revealing chromophobe RCC with classic morphology. Bone biopsy confirmed skeletal metastases 38 months after initial diagnosis. Although invasion of the renal vein and retrograde venous invasion are characteristically seen in clear cell RCC, this unusual phenomenon may also occur in chromophobe RCC, despite its unique tumor biology. This and gain of chromosome 21, which was postulated to be associated with aggressive behavior in a previous report, were associated with adverse behavior in our patient, who had short-term progression to multi-organ metastatic disease.
Milk Flow Rates from bottle nipples used after hospital discharge

Purpose:To test the milk flow rates and variability in flow rates of bottle nipples used after hospital discharge. Study Design and Methods:Twenty-six nipple types that represented 15 common brands as well as variety in price per nipple and store location sold (e.g., Babies R' Us, Walmart, Dollar Store) were chosen for testing. Ten of each nipple type (n = 260 total) were tested by measuring the amount of infant formula expressed in 1 minute using a breast pump. Mean milk flow rate (mL/min) and coefficient of variation (CV) were calculated. Flow rates of nipples within brand were compared statistically. Results:Milk flow rates varied from 1.68 mL/min for the Avent Natural Newborn Flow to 85.34 mL/min for the Dr. Brown's Standard Y-cut. Variability between nipple types also varied widely, from . 03 for the Dr. Brown's Standard Level 3 to . 37 for MAM Nipple 1 Slow Flow. Clinical Implications:The extreme range of milk flow rates found may be significant for medically fragile infants being discharged home who are continuing to develop oral feeding skills. The name of the nipple does not provide clear information about the flow rate to guide parents in decision making. Variability in flow rates within nipples of the same type may complicate oral feeding for the medically fragile infant who may not be able to adapt easily to change in flow rates. Both flow rate and variability should be considered when guiding parents to a nipple choice.
Data-driven parameterization of the generalized Langevin equation

Significance The generalized Langevin equation (GLE) provides a precise description of coarse-grained variable dynamics in reduced dimension models. However, computation of the memory kernel poses a major challenge to the practical use of the GLE. This paper presents a data-driven approach to compute the memory kernel, relying on a hierarchy of parameterized rational approximations in terms of the Laplace transform, which can be expanded to arbitrarily high order as necessary. This parameterization makes it convenient to represent the GLE via an extended stochastic model where the memory term is eliminated by properly introducing auxiliary variables. The present method is well-suited for constructing reduced models for nonequilibrium properties of complex systems such as biomolecules, chemical reaction networks, and climate simulations. We present a data-driven approach to determine the memory kernel and random noise in generalized Langevin equations. To facilitate practical implementations, we parameterize the kernel function in the Laplace domain by a rational function, with coefficients directly linked to the equilibrium statistics of the coarse-grain variables. We show that such an approximation can be constructed to arbitrarily high order and the resulting generalized Langevin dynamics can be embedded in an extended stochastic model without explicit memory. We demonstrate how to introduce the stochastic noise so that the second fluctuation-dissipation theorem is exactly satisfied. Results from several numerical tests are presented to demonstrate the effectiveness of the proposed method.