Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of types and amounts of stabilizers on physical and sensory characteristics of cloudy ready-to-drink mulberry fruit juice

In this study, the pH of mulberry juice was optimized for high anthocyanin content and an attractive red color. Mulberry juice pH values of 2.5, 4.0, 6.0, and 8.0 were evaluated. A pH of 2.5 gave an anthocyanin content of 541.39 ± 106.43 mg of cyanidin-3-glucoside per liter, and the a* value was 14 ± 1.00. The effects of stabilizers (CMC and xanthan gum) on the physical characteristics of cloudy ready-to-drink mulberry fruit juice (via the addition of mulberry fruit pulp at a mass fraction of 5%) during storage (4°C for 1 week) were also determined using different mass fractions of the stabilizers (0.1%, 0.3%, and 0.5%). Increasing the stabilizer mass fraction increased the viscosity, turbidity, stability of turbidity, and h* value. Using xanthan gum as the stabilizer produced better results for these parameters than CMC. The type of stabilizer and its mass fraction had no effect on most sensory characteristics, including appearance, color, taste, texture, and overall acceptability (P ≥ 0.05), but did affect the odor (P ≥ 0.05). Xanthan gum stabilizer gave the juice a better odor than CMC. Cloudy mulberry juice containing 0.5% xanthan gum as the stabilizer had the highest acceptance rate among panelists (average acceptance was 6.90 ± 1.37 points) and produced no precipitate during storage.
IL-4 in the Brain: A Cytokine To Remember

IL-4 has been extensively studied in the context of its role in immunity. Accumulating evidence indicates, however, that it also plays a critical role in higher functions of the normal brain, such as memory and learning. In this review, we summarize current knowledge of the basic immunology of IL-4, describe how and where this cytokine appears to operate in normal brain function, and propose a hypothesis concerning its potential role in neurological pathologies.
ETAF: An extended trust antecedents framework for trust prediction

Trust is one source of information that has been widely adopted to personalize online services for users, such as in product recommendations. However, trust information is usually very sparse or unavailable for most online systems. To narrow this gap, we propose a principled approach that predicts implicit trust from users' interactions, by extending a well-known trust antecedents framework. Specifically, we consider both local and global trustworthiness of target users, and form a personalized trust metric by further taking into account the active user's propensity to trust. Experimental results on two real-world datasets show that our approach works better than contemporary counterparts in terms of trust ranking performance when direct user interactions are limited.
SIMULTANEOUS RECORDING OF ELECTRIC AND METABOLIC BRAIN ACTIVITY

Electric and metabolic brain activities were controlled for 49 persons by means of electroencephalography (EEG) and near infrared spectroscopy (NIRS) during difierent physiological and psychological states, e.g. eyes open or closed, hy- perpnoea (HV) or apnoea (AP) and during calculation (addition of one- (CAL.S.) or two-digit numbers (CAL C.)) or Raven's test { set A (RAV A) or more di-- cult set C (RAV C) or TAT. Both diagnostic methods conflrm one another. But sometimes there are more expressive changes in one method than in another, e.g. during HV it is a more prominent deoxyhemoglobin (CO2Hb) increase than an alpha frequency band increase in EEG curves. On the other side, very marked alpha frequency decreasing in EEG during eyes open is followed by only a weak oxyhemoglobin (O2Hb) rise. Synchronous activities are clearly visible during psy- chic test: increasing O2Hb in NIRS and increasing delta frequency band in EEG spectrum. Decreasing alpha with increasing theta activity during relaxation and somnolence is accompanied by decreasing O2Hb and prominent increasing CO2Hb. Inter individually difierences are often but not big. We suggest both methods are good tools for attention and psychic states control.
Ocular Inserts for Sustained Release of the Angiotensin-Converting Enzyme 2 Activator, Diminazene Aceturate, to Treat Glaucoma in Rats

The aim of this study was to develop and evaluate the effects of chitosan inserts for sustained release of the angiotensin-converting enzyme 2 (ACE2) activator, diminazene aceturate (DIZE), in experimental glaucoma. Monolayer DIZE loaded inserts (D+I) were prepared and characterized through swelling, attenuated total reflectance Fourier transformed infrared spectroscopy (ATR-FTIR), differential scanning calorimetry (DSC) and in vitro drug release. Functionally, the effects of D+I were tested in glaucomatous rats. Glaucoma was induced by weekly injections of hyaluronic acid (HA) into the anterior chamber and intraocular pressure (IOP) measurements were performed. Retinal ganglion cells (RGC) and optic nerve head cupping were evaluated in histological sections. Biodistribution of the drug was accessed by scintigraphic images and ex vivo radiation counting. We found that DIZE increased the swelling index of the inserts. Also, it was molecularly dispersed and interspersed in the polymeric matrix as a freebase. DIZE did not lose its chemical integrity and activity when loaded in the inserts. The functional evaluation demonstrated that D+I decreased the IOP and maintained the IOP lowered for up to one month (last week: 11.0±0.7 mmHg). This effect of D+I prevented the loss of RGC and degeneration of the optic nerve. No toxic effects in the eyes related to application of the inserts were observed. Moreover, biodistribution studies showed that D+I prolonged the retention of DIZE in the corneal site. We concluded that D+I provided sustained DIZE delivery in vivo, thereby evidencing the potential application of polymeric-based DIZE inserts for glaucoma management.
Lower Extremity Muscle Activity During a Women’s Overhand Lacrosse Shot

Abstract The purpose of this study was to describe lower extremity muscle activity during the lacrosse shot. Participants (n=5 females, age 22±2 years, body height 162.6±15.2 cm, body mass 63.7±23.6 kg) were free from injury and had at least one year of lacrosse experience. The lead leg was instrumented with electromyography (EMG) leads to measure muscle activity of the rectus femoris (RF), biceps femoris (BF), tibialis anterior (TA), and medial gastrocnemius (GA). Participants completed five trials of a warm-up speed shot (Slow) and a game speed shot (Fast). Video analysis was used to identify the discrete events defining specific movement phases. Full-wave rectified data were averaged per muscle per phase (Crank Back Minor, Crank Back Major, Stick Acceleration, Stick Deceleration). Average EMG per muscle was analyzed using a 4 (Phase) x 2 (Speed) ANOVA. BF was greater during Fast vs. Slow for all phases (p<0.05), while TA was not influenced by either Phase or Speed (p>0.05). RF and GA were each influenced by the interaction of Phase and Speed (p<0.05) with GA being greater during Fast vs. Slow shots during all phases and RF greater during Crank Back Minor and Major as well as Stick Deceleration (p<0.05) but only tended to be greater during Stick Acceleration (p=0.076) for Fast vs. Slow. The greater muscle activity (BF, RF, GA) during Fast vs. Slow shots may have been related to a faster approach speed and/or need to create a stiff lower extremity to allow for faster upper extremity movements.
Small RNA-Based Antiviral Defense in the Phytopathogenic Fungus Colletotrichum higginsianum

Even though the fungal kingdom contains more than 3 million species, little is known about the biological roles of RNA silencing in fungi. The Colletotrichum genus comprises fungal species that are pathogenic for a wide range of crop species worldwide. To investigate the role of RNA silencing in the ascomycete fungus Colletotrichum higginsianum, knock-out mutants affecting genes for three RNA-dependent RNA polymerase (RDR), two Dicer-like (DCL), and two Argonaute (AGO) proteins were generated by targeted gene replacement. No effects were observed on vegetative growth for any mutant strain when grown on complex or minimal media. However, Δdcl1, Δdcl1Δdcl2 double mutant, and Δago1 strains showed severe defects in conidiation and conidia morphology. Total RNA transcripts and small RNA populations were analyzed in parental and mutant strains. The greatest effects on both RNA populations was observed in the Δdcl1, Δdcl1Δdcl2, and Δago1 strains, in which a previously uncharacterized dsRNA mycovirus [termed Colletotrichum higginsianum non-segmented dsRNA virus 1 (ChNRV1)] was derepressed. Phylogenetic analyses clearly showed a close relationship between ChNRV1 and members of the segmented Partitiviridae family, despite the non-segmented nature of the genome. Immunoprecipitation of small RNAs associated with AGO1 showed abundant loading of 5’U-containing viral siRNA. C. higginsianum parental and Δdcl1 mutant strains cured of ChNRV1 revealed that the conidiation and spore morphology defects were primarily caused by ChNRV1. Based on these results, RNA silencing involving ChDCL1 and ChAGO1 in C. higginsianum is proposed to function as an antiviral mechanism.
Hannah Arendt’s vita activa: A valuable contribution to occupational science

ABSTRACT Occupational science is undergoing dynamic development and claims have been articulated that human occupation must be understood from multiple ontological standpoints. Hannah Arendt (1906–1975) is known for her work The Human Condition in which she explored human occupation from a philosophical and political standpoint. She distinguished the modalities labor, work and action, and labelled them vita activa. The aim of this paper is to present Arendt and her vita activa, in order to provide examples of its relevance for occupational science, showing how vita activa can assist occupational scientists to take a deeper perspective on human occupation. According to Arendt, human occupation is always conditioned. The condition for labor is necessity, which reflects human biological needs and represents the basics of life. The condition for work is utility, as something persistent and durable is produced. Action is the activity that takes place between people without the intermediary of things. Similar to occupational science, vita activa is concerned with human doing but their origins differ. Arendt also emphasized the public sphere as an arena for human occupation, a viewpoint that is shared with recent occupational science literature. The need to expand the scope of occupational science to encompass all aspects of human occupations, including the deleterious, has been expressed and vita activa can contribute to broadening this perspective. Examples of the need for sustainability in working life are also presented in this paper.
The Shattered Gradients Problem: If resnets are the answer, then what is the question?

A long-standing obstacle to progress in deep learning is the problem of vanishing and exploding gradients. Although, the problem has largely been overcome via carefully constructed initializations and batch normalization, architectures incorporating skip-connections such as highway and resnets perform much better than standard feedforward architectures despite well-chosen initialization and batch normalization. In this paper, we identify the shattered gradients problem. Specifically, we show that the correlation between gradients in standard feedforward networks decays exponentially with depth resulting in gradients that resemble white noise whereas, in contrast, the gradients in architectures with skip-connections are far more resistant to shattering, decaying sublinearly. Detailed empirical evidence is presented in support of the analysis, on both fully-connected networks and convnets. Finally, we present a new "looks linear" (LL) initialization that prevents shattering, with preliminary experiments showing the new initialization allows to train very deep networks without the addition of skip-connections.
Bayesian Inference of the Evolution of a Phenotype Distribution on a Phylogenetic Tree

The distribution of a phenotype on a phylogenetic tree is often a quantity of interest. Many phenotypes have imperfect heritability, so that a measurement of the phenotype for an individual can be thought of as a single realization from the phenotype distribution of that individual. If all individuals in a phylogeny had the same phenotype distribution, measured phenotypes would be randomly distributed on the tree leaves. This is, however, often not the case, implying that the phenotype distribution evolves over time. Here we propose a new model based on this principle of evolving phenotype distribution on the branches of a phylogeny, which is different from ancestral state reconstruction where the phenotype itself is assumed to evolve. We develop an efficient Bayesian inference method to estimate the parameters of our model and to test the evidence for changes in the phenotype distribution. We use multiple simulated data sets to show that our algorithm has good sensitivity and specificity properties. Since our method identifies branches on the tree on which the phenotype distribution has changed, it is able to break down a tree into components for which this distribution is unique and constant. We present two applications of our method, one investigating the association between HIV genetic variation and human leukocyte antigen and the other studying host range distribution in a lineage of Salmonella enterica, and we discuss many other potential applications.
2 3 A pr 2 00 5 On the complete integrability and linearization of certain second order nonlinear ordinary differential equations

A method of finding general solutions of second-order nonlinear ordinary differential equations by extending the Prelle-Singer (PS) method is briefly discussed. We explore integrating factors, integrals of motion and the general solution associated with several dynamical systems discussed in the current literature by employing our modifications and extensions of the PS method. In addition to the above we introduce a novel way of deriving linearizing transformations from the first integrals to linearize the second order nonlinear ordinary differential equations to free particle equation. We illustrate the theory with several potentially important examples and show that our procedure is widely applicable.
Entwicklung und Validierung der Online-Privatheitskompetenzskala (OPLIS)

Zusammenfassung. Online-Privatheitskompetenz gilt in der medienpsychologischen Forschung als wichtiger Einflussfaktor auf das Privatheitsverhalten in Online-Umgebungen. Eine Skala zur Erfassung dieser Kompetenz fehlt jedoch. Ziel dieser Arbeit war entsprechend die Entwicklung und Validierung einer umfassenden Skala zur Messung von Online-Privatheitskompetenz. In Vorarbeiten wurden anhand einer qualitativen Inhaltsanalyse die Dimensionen des Konstrukts identifiziert (Trepte et al., 2015). Darauf aufbauend wurde aus 113 Wissensfragen eine aus 20 Fragen bestehende Skala entwickelt, die vier Wissensbereiche abdeckt: Wissen uber 1) institutionelle Praktiken, 2) technische Aspekte des Datenschutzes, 3) Datenschutzrecht und 4) Datenschutzstrategien. Die Ergebnisse von drei konsekutiven Studien sprechen fur ein Bi-Faktor-Modell, wobei der globale Faktor die Online-Privatheitskompetenz widerspiegelt. Die Konstrukt- und Kriteriumsvaliditat wurde anhand einer Quotenstichprobe deutscher Internetnutzender (N = 1 945) .
Effects of contrast material on single-volume proton MR spectroscopy.

BACKGROUND AND PURPOSE Administration of contrast material before proton MR spectroscopy may allow more accurate placement of the volume of interest, particularly in tumors; yet, some data have suggested that contrast material may alter the results of MR spectroscopy. To determine the validity of this contention, we performed pre- and postcontrast MR spectroscopy in patients with brain tumors and compared the results with those obtained from a phantom. METHODS Ten patients with astrocytomas were examined with single-volume MR spectroscopy before and after administration of contrast material. Voxel placement was identical for all studies. Peak area, peak height, and width at half maximum were measured for N-acetyl aspartate (NAA), creatine (Cr), and choline (Cho) in all studies. A phantom containing a 10 mmol concentration of NAA, Cr, and Cho was prepared in phosphate-buffered saline and mixed with contrast concentrations varying from 0.1 to 1.0 mmol. The phantom was studied by MR spectroscopy with the same parameters as used for the clinical studies. RESULTS No significant differences were found between the pre- and postcontrast MR spectroscopy studies for the three parameters measured. In phantom studies, there was a significant decline in the Cho peak area and height and an increase in the width at half maximum as the concentration of contrast material increased from 0.1 to 1.0 mmol. NAA and Cr peaks showed no significant changes in peak height or area. CONCLUSION Contrast material may be administered before clinical MR spectroscopy without affecting its interpretation.
Modelling Social Dilemmas: A Regret-driven Neural Network Model

Abstract Marchiori and Warglien (2008, Science, 319(5866), 1111–1113) showed that a simple regret-driven neural network model outperforms almost all competing models when predicting human choice behaviour in games with ‘unique equilibrium in mixed strategies’. Considering its effectiveness in this class of games, we scale up the model to account for strategically more important decision-making scenarios like prisoners’ dilemma (PD). The modification is based on the assumption that the trajectory of behaviour observed in a repeated PD experiment is the result of the bidirectional attraction between pareto-optimal (mutual cooperation) versus self-interested defection (mutual defection) in repeated PD game. The simulation results significantly capture the qualitative trends in behaviour over time.
Imaging Amnestic Mild Cognitive Impairment: Neuroinflammation, Beta-amyloid and Glutathione

Amnestic mild cognitive impairment (aMCI) is defined as a transitional state between normal aging and Alzheimer’s disease (AD). Neuroinflammation, amyloid accumulation and oxidative stress have been shown to contribute to the pathology of AD, however whether these processes occur in prodromal individuals is still not well understood. The main aim was to investigate, with the use of positron emission tomography, whether neuroinflammation is increased in aMCI patients and if it relates to amyloid burden in-vivo. Our exploratory aim was to measure glutathione, the brain’s major antioxidant, in-vivo with the use of magnetic resonance spectroscopy. No significant differences in [F]-FEPPA binding and glutathione levels were observed between healthy volunteers and aMCI patients. In contrast, aMCI patients were found to have significantly more amyloid in the cortical regions. Our findings suggest that amyloid pathology is an early event, whereas neuroinflammation and alterations in glutathione may occur only after conversion to AD.
Alcohol consumption and domain-specific cognitive function in older adults: longitudinal data from the Johns Hopkins Precursors Study.

OBJECTIVES The association of alcohol consumption with performance in different cognitive domains has not been well studied. METHODS The Johns Hopkins Precursors Study was used to examine associations between prospectively collected information about alcohol consumption ascertained on multiple occasions starting at age 55 years on average with domain-specific cognition at age 72 years. Cognitive variables measured phonemic and semantic fluency, attention, verbal memory, and global cognition. RESULTS Controlling for age, hypertension, smoking status, sex, and other cognitive variables, higher average weekly quantity and frequency of alcohol consumed in midlife were associated with lower phonemic fluency. There were no associations with four other measures of cognitive function. With respect to frequency of alcohol intake, phonemic fluency was significantly better among those who drank three to four alcoholic beverages per week as compared with daily or almost daily drinkers. A measure of global cognition was not associated with alcohol intake at any point over the follow-up. DISCUSSION Results suggest that higher alcohol consumption in midlife may impair some components of executive function in late life.
The INTERSPEECH 2014 computational paralinguistics challenge: cognitive & physical load

The INTERSPEECH 2014 Computational Paralinguistics Challenge provides for the first time a unified test-bed for the automatic recognition of speakers’ cognitive and physical load in speech. In this paper, we describe these two Sub-Challenges, their conditions, baseline results and experimental procedures, as well as the COMPARE baseline features generated with the openSMILE toolkit and provided to the participants in the Challenge.
A Framework for Enhancing Video Viewing Experience with Haptic Effects of Motion

This work aims at enhancing a classical video viewing experience by introducing realistic haptic feelings in a consumer environment. More precisely, a complete framework to both produce and render the motion embedded in an audiovisual content is proposed to enhance a natural movie viewing session. We especially consider the case of a ﬁrst-person point of view audiovisual content and we propose a general work-ﬂow to address this problem. This latter includes a novel approach to both capture the motion and video of the scene of interest, together with a haptic rendering system for generating a sensation of motion. A complete methodology to evaluate the relevance of our framework is ﬁnally proposed and demonstrates the interest of our approach
Localization and hormonal regulation of endometrial matrix metalloproteinase-26 in the rhesus macaque.

BACKGROUND The current understanding of hormonal regulation of matrix metalloproteinase-26 (MMP-26) in the primate endometrium is incomplete. The goal of this work was to clarify estrogen and progesterone regulation of MMP-26 in the endometrium of ovariectomized, hormone-treated rhesus macaques. METHODS Ovariectomized rhesus macaques (n= 66) were treated with estradiol (E(2)), E(2) plus progesterone, E(2) followed by progesterone alone or no hormone. Endometrium was collected from the hormone-treated animals during the early, mid- and late proliferative and secretory phases of the artificial menstrual cycle. MMP-26 expression was quantified by real-time PCR, and MMP-26 transcript and protein were localized by in situ hybridization and immunohistochemistry and correlated with estrogen receptor 1 and progesterone receptor (PGR). RESULTS MMP-26 was localized to glandular epithelium and was undetectable in the endometrial stroma and vasculature. MMP-26 transcript levels were minimal in the hormone-deprived macaques and treatment with E(2) alone did not affect MMP-26 levels. Treatment with progesterone both in the presence and absence of E(2) stimulated MMP-26 expression in the early and mid-secretory phases (P < 0.001). MMP-26 expression preceded decidualization of endometrial stroma. MMP-26 levels then declined to baseline in the late secretory phase (P < 0.01) despite continued E(2) plus progesterone treatment. Loss of detectable MMP-26 expression in the late secretory phase was correlated with late secretory phase loss of glandular epithelial PGR. CONCLUSIONS Endometrial MMP-26 expression is dependent on the presence of progesterone in the early secretory phase and then gradually becomes refractory to progesterone stimulation in the late secretory phase. In the macaque, MMP-26 is a marker of the pre-decidual, secretory endometrium. During the second half of the late secretory phase, and during decidualization, MMP-26 loses its response to progesterone concurrent with the loss of epithelial PGR. The decline in MMP-26 levels between the mid- and late secretory phases may play a role in the receptive window for embryo implantation.