Miracle-dz/UniFAR-FTUs huggingface dataset:
FESCIM: Fair, Efficient, and Secure Cooperation Incentive Mechanism for Multihop Cellular Networks

In multihop cellular networks, the mobile nodes usually relay others' packets for enhancing the network performance and deployment. However, selfish nodes usually do not cooperate but make use of the cooperative nodes to relay their packets, which has a negative effect on the network fairness and performance. In this paper, we propose a fair and efficient incentive mechanism to stimulate the node cooperation. Our mechanism applies a fair charging policy by charging the source and destination nodes when both of them benefit from the communication. To implement this charging policy efficiently, hashing operations are used in the ACK packets to reduce the number of public-key-cryptography operations. Moreover, reducing the overhead of the payment checks is essential for the efficient implementation of the incentive mechanism due to the large number of payment transactions. Instead of generating a check per message, a small-size check can be generated per route, and a check submission scheme is proposed to reduce the number of submitted checks and protect against collusion attacks. Extensive analysis and simulations demonstrate that our mechanism can secure the payment and significantly reduce the checks' overhead, and the fair charging policy can be implemented almost computationally free by using hashing operations.
Experience with processes and monitors in Mesa

The use of monitors for describing concurrency has been much discussed in the literature. When monitors are used in real systems of any size, however, a number of problems arise which have not been adequately dealt with: the semantics of nested monitor calls; the various ways of defining the meaning of WAIT; priority scheduling; handling of timeouts, aborts and other exceptional conditions; interactions with process creation and destruction; monitoring large numbers of small objects. These problems are addressed by the facilities described here for concurrent programming in Mesa. Experience with several substantial applications gives us some confidence in the validity of our solutions.
Characterization of T-Bet and Eomes in Peripheral Human Immune Cells

The T-box transcription factors T-bet and Eomesodermin (Eomes) have been well defined as key drivers of immune cell development and cytolytic function. While the majority of studies have defined the roles of these factors in the context of murine T-cells, recent results have revealed that T-bet, and possibly Eomes, are expressed in other immune cell subsets. To date, the expression patterns of these factors in subsets of human peripheral blood mononuclear cells beyond T-cells remain relatively uncharacterized. In this study, we used multiparametric flow cytometry to characterize T-bet and Eomes expression in major human blood cell subsets, including total CD4+ and CD8+ T-cells, γδ T-cells, invariant NKT cells, natural killer cells, B-cells, and dendritic cells. Our studies identified novel cell subsets that express T-bet and Eomes and raise implications for their possible functions in the context of other human immune cell subsets besides their well-known roles in T-cells.
Identification of ethnomedicinal plants (Rauvolfioideae: Apocynaceae) through DNA barcoding from northeast India

Background: DNA barcode-based molecular characterization is in practice for plants, but yet lacks total agreement considering the selection of marker. Plant species of subfamily Rauvolfioideae have long been used as herbal medicine by the majority of tribal people in Northeast (NE) India and at present holds mass effect on the society. Hence, there is an urgent need of correct taxonomic inventorization vis-à-vis species level molecular characterization of important medicinal plants. Objective: To test the efficiency of matK in species delineation like DNA barcoding in Rauvolfiadae (Apocynaceae). Materials and Methods: In this study, the core DNA barcode matK and trnH-psbA sequences are examined for differentiation of selected ethnomedicinal plants of Apocynaceae. DNA from young leaves of selected species was isolated, and matK gene (~800 bp) and trnH-psbA spacer (~450 bp) of Chloroplast DNA was amplified for species level identification. Results: The ~758 bp matK sequence in comparison to the trnH-psbA showed easy amplification, alignment, and high level of discrimination value among the medicinal Rauvolfioidae species. Intergenic spacer trnH-psbA is also exhibited persistent problem in obtaining constant bidirectional sequences. Partial matK sequences exhibited 3 indels in multiple of 3 at 5 end. Evidently, generated matK sequences are clustered cohesively, with their conspecific Genbank sequences. However, repeat structures with AT-rich regions, possessing indels in multiple of 3, could be utilized as qualitative molecular markers in further studies both at the intra-specific and shallow inter-specific levels like the intergenic spacers of CpDNA. Conclusion: matK sequence information could help in correct species identification for medicinal plants of Rauvolfioideae.
Involvement of auxin dynamics in hypergravity-induced promotion of lignin-related gene expression in Arabidopsis inflorescence stems

Recent studies have shown that hypergravity enhances lignification through up-regulation of the expression of lignin biosynthesis-related genes, although its hormonal signalling mechanism is unknown. The effects of hypergravity on auxin dynamics were examined using Arabidopsis plants that were transformed with the auxin reporter gene construct DR5::GUS. Hypergravity treatment at 300 g significantly increased β-glucuronidase activity in inflorescence stems of DR5::GUS plants, indicating that endogenous auxin accumulation was enhanced by hypergravity treatment. The hypergravity-related increased expression levels of both DR5::GUS and lignin biosynthesis-related genes in inflorescence stems were suppressed after disbudding, indicating that the increased expression of lignin biosynthesis-related genes is dependent on an increase in auxin influx from the shoot apex.
Association between immigrant background and ADHD: a nationwide population-based case-control study.

BACKGROUND Information about psychiatric disorders among those with immigrant parents is important for early detection and service development. The aim of this study is to examine the association between parental immigration and the diagnosis of attention-deficit hyperactivity disorder (ADHD) in offspring in Finland. METHODS This matched case-control study was based on a national birth cohort. The sample included all singletons who were born in Finland in 1991-2005 and diagnosed with ADHD by the year 2011 (n = 10,409) and their matched controls (n = 39,124). Nationwide registers were used to identify participants and to gather information on the parents' country of birth and native language. Conditional logistic regression analyses were conducted using maternal and paternal migration status and region of birth as well as time since maternal migration as exposure factors. RESULTS The likelihood of being diagnosed with ADHD was significantly increased among children of two immigrant parents [adjusted odds ratio (aOR) 4.7, 95% CI 3.4-6.6] and children of an immigrant father (aOR 1.9, 95% CI 1.6-2.2). The likelihood of receiving an ADHD diagnosis was equal among children whose mother was a recent immigrant when she gave birth and those whose mother had stayed in Finland at least for a year before birth. The association between parental migration and ADHD diagnosis was strongest among fathers born in sub-Saharan Africa or Latin America and among mothers born in sub-Saharan Africa or North Africa and Middle East. Children, whose parents were born in countries with low Human Development Index (HDI), were more often diagnosed with ADHD. CONCLUSIONS The increased likelihood of ADHD diagnosis among children of immigrants indicates increased exposure to environmental risk factors, differences in the use of health services, or challenges in diagnosing immigrants' children.
Fault tolerance, channel coding and arithmetic source coding combined

A complete source and channel coding system is protected from both channel errors and errors emanating from internal hardware failures by introducing redundancy in the source encoding and decoding procedures as well as in frequently inserting parity symbols generated by a burst-detecting convolutional code. The combined protected system can detect errors in any significant subsystems whether from transmission errors or hardware faults. The arithmetic source coding procedures are augmented with a few checking operations which detect failure effects at each iteration of the algorithm. The normal input symbol sequence has a parity symbol inserted sparsely; every n/sup th/ symbol is determined by a high-rate burst-detecting convolutional code. These parity values provide end to end error detection for channel and hardware-based errors. The favorable probability of detection performance is evaluated and the low overhead costs as measured by increased compression length of the modified source coding procedure are determined.
Size effects resolve discrepancies in 40 years of work on low-temperature plasticity in olivine

When deforming by low-temperature plasticity, the strength of the mantle mineral olivine is controlled by its grain size. The strength of olivine at low temperatures and high stresses in Earth’s lithospheric mantle exerts a critical control on many geodynamic processes, including lithospheric flexure and the formation of plate boundaries. Unfortunately, laboratory-derived values of the strength of olivine at lithospheric conditions are highly variable and significantly disagree with those inferred from geophysical observations. We demonstrate via nanoindentation that the strength of olivine depends on the length scale of deformation, with experiments on smaller volumes of material exhibiting larger yield stresses. This “size effect” resolves discrepancies among previous measurements of olivine strength using other techniques. It also corroborates the most recent flow law for olivine, which proposes a much weaker lithospheric mantle than previously estimated, thus bringing experimental measurements into closer alignment with geophysical constraints. Further implications include an increased difficulty of activating plasticity in cold, fine-grained shear zones and an impact on the evolution of fault surface roughness due to the size-dependent deformation of nanometer- to micrometer-sized asperities.
Serum 14-3-3η is a Novel Marker that Complements Current Serological Measurements to Enhance Detection of Patients with Rheumatoid Arthritis

Objective. Serum 14-3-3η is a novel joint-derived proinflammatory mediator implicated in the pathogenesis of rheumatoid arthritis (RA). In our study, we assessed the diagnostic utility of 14-3-3η and its association with standard clinical and serological measures. Methods. A quantitative ELISA was used to assess 14-3-3η levels. Early (n = 99) and established patients with RA (n = 135) were compared to all controls (n = 385), including healthy subjects (n = 189). The sensitivity, specificity, positive and negative predictive values of 14-3-3η, and the likelihood ratios (LR) for RA were determined through receiver-operator curve analysis. The incremental value of adding 14-3-3η to anticitrullinated protein antibody (ACPA) and rheumatoid factor (RF) in diagnosing early and established RA was assessed. Results. Serum 14-3-3η differentiated established patients with RA from healthy individuals and all controls (p < 0.0001). A serum 14-3-3η cutoff of ≥ 0.19 ng/ml delivered a sensitivity and specificity of 77% and 93%, respectively, with corresponding LR positivity of 10.4. At this cutoff in early RA, 64% of patients with early RA were positive for 14-3-3η, with a corresponding specificity of 93% (LR+ of 8.6), while 59% and 57% were positive for ACPA or RF, respectively. When ACPA, RF, and 14-3-3η positivity were used in combination, 77 of the 99 patients (78%) with early RA were positive for any 1 of the 3 markers. Serum 14-3-3η did not correlate with C-reactive protein, erythrocyte sedimentation rate, or Disease Activity Score, but patients who were 14-3-3η-positive had significantly worse disease. Conclusion. Serum 14-3-3η is a novel RA mechanistic marker that is highly specific, associated with worse disease, and complements current markers, enabling a more accurate diagnosis of RA.
Predicting Chinese Abbreviations with Minimum Semantic Unit and Global Constraints

We propose a new Chinese abbreviation prediction method which can incorporate rich local information while generating the abbreviation globally. Different to previous character tagging methods, we introduce the minimum semantic unit, which is more fine-grained than character but more coarse-grained than word, to capture word level information in the sequence labeling framework. To solve the “character duplication” problem in Chinese abbreviation prediction, we also use a substring tagging strategy to generate local substring tagging candidates. We use an integer linear programming (ILP) formulation with various constraints to globally decode the final abbreviation from the generated candidates. Experiments show that our method outperforms the state-of-the-art systems, without using any extra resource.
New local anesthetics for pediatric anesthesia

Purpose of review To evaluate the relevance of new local anesthetics in pediatric regional anesthesia. Recent findings Several studies evaluate the pharmacokinetics of new local anesthetics, like ropivacaine and levobupivacaine, and compare their safety and efficacy with the old but widely used bupivacaine. Summary The goal of anesthetists using regional anesthesia is to use local anesthestics that are as safe and effective as possible, with a rapid onset and a long duration. Even though adequate dose guidelines are available, several toxic effects are reported with the use of bupivacaine in children due to inadvertent intravenous injection, long-term infusion (> 48 h) or administration in newborn babies and infants with reduced metabolism. Ropivacaine and levobupivacaine are new local anesthetics with a wider safety margin that have similar characteristics: both of them are pure S-(−)-enantiomers whose main pharmacological features are less cardio- and neuro-affinity and -toxicity in comparison with the racemic formulae and R-isomers, and a differential neural blockade with less motor than sensory block. Several clinical studies in children compare ropivacaine and levobupivacaine with bupivacaine.
Oil Wastes as Unconventional Substrates for Rhamnolipid Biosurfactant Production by Pseudomonas aeruginosa LBI

Oil wastes were evaluated as alternative low‐cost substrates for the production of rhamnolipids by Pseudomonas aeruginosa LBI strain. Wastes obtained from soybean, cottonseed, babassu, palm, and corn oil refinery were tested. The soybean soapstock waste was the best substrate, generating 11.7 g/L of rhamnolipids with a surface tension of 26.9 mN/m, a critical micelle concentration of 51.5 mg/L, and a production yield of 75%. The monorhamnolipid RhaC10C10 predominates when P. aeruginosa LBI was cultivated on hydrophobic substrates, whereas hydrophilic carbon sources form the dirhamnolipid Rha2C10C10 predominantly.
Illusory continuity of intermittent pure tone in binaural listening and its dependency on interaural time difference

Illusory continuity is known as a psychoacoustical phenomenon in hearing; i.e. an intermittent pure tone may be perceived as if it was continuous, when it is padded with enough large white noise. There are many researches related to this issue in monaural listening. It is said that such illusory continuity is observed when there is no evidence of discontinuity and level of the white noise is large enough to mask the pure tone. In this paper, we investigated illusory continuity in binaural listening, and measured its threshold levels according to some interaural time differences (ITDs). The ITDs simulate a sense of direction about sound sources and give new information for evidence of discontinuity, which should be expected to promote the illusory continuity. As a result, the threshold level of illusory continuity in binaural listening depended on ITDs between tone target and noise masker. The increase of threshold level was minimum when the target and masker had the same ITD.
Search with multi-worker firms

We present a generalization of the standard random-search model of unemployment in which firms hire multiple workers and in which the hiring process is time-consuming as well as costly. We follow Stole and Zwiebel (1996a,b) and assume that wages are determined by continuous bargaining between the firm and its employees. The model generates a non-trivial dispersion of firm sizes; when firms' production technologies exhibit decreasing returns to labor, it also generates wage dispersion, even when all firms and all workers are ex ante identical. We characterize the steady-state equilibrium and show that, with a suitably chosen distribution of ex ante heterogeneity across firms, it is consistent with several important stylized facts about the joint distribution of firm size, firm growth, and wages in the U.S. economy. We also conduct a numerical investigation of the out-of-steady state dynamics of our model. We find that the responses of unemployment and of the vacancy to unemployment ratio to a shock to labor productivity can be somewhat more persistent than in the Mortensen-Pissarides benchmark where each firm employs a single worker.
Mechanisms and Prospects of Ischemic Tolerance Induced by Cerebral Preconditioning

In the brain, brief episodes of ischemia induce tolerance against a subsequent severe episode of ischemia. This phenomenon of endogenous neuroprotection is known as preconditioning-induced ischemic tolerance. The purpose of this review is to summarize the current state of knowledge about mechanisms and potential applications of cerebral preconditioning and ischemic tolerance. Articles related to the terms ischemic preconditioning and ischemic tolerance were systematically searched via MEDLINE/PubMed, and articles published in English related to the nervous system were selected and analyzed. The past two decades have provided interesting insights into the molecular mechanisms of this neuroprotective phenomenon. Although both rapid and delayed types of tolerance have been documented in experimental settings, the delayed type has been found to be more prominent in the case of neuronal ischemic tolerance. Many intracellular signaling pathways have been implicated regarding ischemic preconditioning. Most of these are associated with membrane receptors, kinase cascades, and transcription factors. Moreover, ischemic tolerance can be induced by exposing animals or cells to diverse types of endogenous and exogenous stimuli that are not necessarily hypoxic or ischemic in nature. These cross-tolerances raise the hope that, in the future, it will be possible to pharmacologically activate or mimic ischemic tolerance in the human brain. Another promising approach is remote preconditioning in which preconditioning of one organ or system leads to the protection of a different (remote) organ that is difficult to target, such as the brain. The preconditioning strategy and related interventions can confer neuroprotection in experimental ischemia, and, thus, have promise for practical applications in cases of vascular neurosurgery and endo-vascular therapy.
Computational Insights into The Neuroprotective Action of Riluzole on 3-Acetylpyridine-Induced Ataxia in Rats

Objective: Intra-peritoneal administration of riluzole has been shown to preserve the membrane properties and firing characteristics of Purkinje neurons in a rat model of cerebellar ataxia induced by 3-acetylpyridine (3-AP). However, the exact mechanism(s) by which riluzole restores the normal electrophysiological properties of Purkinje neurons is not completely understood. Changes in the conductance of several ion channels, including the BK channels, have been proposed as a neuro protective target of riluzole. In this study, the possible cellular effects of riluzole on Purkinje cells from 3-AP-induced ataxic rats that could be responsible for its neuro protective action have been investigated by computer simulations. Materials and Methods: This is a computational stimulation study. The simulation environment enabled a change in the properties of the specific ion channels as the possible mechanism of action of riluzole. This allowed us to study the resulted changes in the firing activity of Purkinje cells without concerns about its other effects and interfering parameters in the experiments. Simulations were performed in the NEURON environment (Version 7.1) in a time step of 25 μs; analyses were conducted using MATLAB r2010a (The Mathworks). Data were given as mean ± SEM. Statistical analyses were performed by the student’s t test, and differences were considered significant if p< 0.05. Results: The computational findings demonstrated that modulation of an individual ion channel current, as suggested by previous experimental studies, should not be considered as the only possible target for the neuro protective effects of riluzole to restore the normal firing activity of Purkinje cells from ataxic rats. Conclusion: Changes in the conductance of several potassium channels, including voltage- gated potassium (Kv1, Kv4) and big Ca2+-activated K+ (BK) channels may be responsible for the neuro protective effect of riluzole against 3-AP induced alterations in the firing properties of Purkinje cells in a rat model of ataxia.
Polymorphisms in the Cell Wall–Spanning Domain of the C Protein β-Antigen in Clinical Streptococcus agalactiae Isolates Are Caused by Genetic Instability of Repeating DNA Sequences

The C protein α- and β-antigens are immunodominant components of the surface of Streptococcus agalactiae, the most frequent cause of neonatal sepsis. Both proteins are thought to contribute significantly to virulence of S. agalactiae. They are mainly expressed by serotypes Ia, Ib, and II. The C protein β-antigen (Cβ-protein) binds to the Fc portion of human IgA and seems to be of importance in bacterial resistance to mucosal immune defense mechanisms. In this study, PCR analysis of S. agalactiae isolates obtained from 189 neonates and 112 pregnant women revealed the presence of the Cβ-protein gene in 19% and 22% of the isolates, respectively. Size polymorphisms of the PCR products within the gene region encoding the cell wall–spanning domain indicated a high degree of genetic variability. Thirteen different variants of the amplified region were differentiated among the 60 Cβ-protein–positive isolates by sequence analysis. In all variants, the polymorphisms were caused by insertions and deletions of repetitive DNA elements that did not alter the open reading frame. Comparison of the Cβ-protein gene polymorphisms showed a significantly higher rate of isolates carrying deletions >50 bp in serotype Ib than in serotype II isolates (p = 0.001); this was also true for neonatal isolates analyzed separately (p = 0.01). Neonatal isolates carried a higher rate of large deletions when compared with maternal isolates; this difference, however, did not reach statistical significance (p = 0.08). We hypothesize that polymorphisms in the cell wall–spanning domain of the Cβ-protein are of functional relevance with regard to maternofetal transmission of the pathogen.