Miracle-dz/UniFAR-FTUs huggingface dataset:
EPSPs of dentate gyrus granule cells during epileptiform bursts of dentate hilar "mossy" cells and area CA3 pyramidal cells in disinhibited rat hippocampal slices

When hippocampal slices are exposed to GABAA antagonists, area CA3 pyramidal cells and dentate hilar “mossy” cells discharge in synchronized epileptiform bursts (Muller and Misgeld, 1991; Scharfman, 1994b). Dentate interneurons are excited simultaneously, but the degree of discharge varies (Scharfman, 1994b). This study primarily examined the activity of dentate granule cells simultaneous to the epileptiform bursts of pyramidal cells and mossy cells. EPSPs followed by large GABAB receptor-mediated IPSPs were generated in granule cells during all epileptiform bursts of pyramidal cells and mossy cells, regardless of whether they were evoked or spontaneous. By simultaneous recording it was determined that granule cell EPSPs began several milliseconds after the start of pyramidal cell bursts (n = 48 simultaneous recordings) and immediately after the first action potential of a mossy cell burst (n = 77). Interneurons were similar to granule cells in the timing of their depolarizations relative to the onset of pyramidal cell (n = 24; Scharfman, 1994b) and mossy cell (n = 9) bursts. All excitatory activity was blocked by bath application of the glutamatergic AMPA/kainate receptor antagonist CNQX (5 microM, n = 5), but not the NMDA receptor antagonist D-APV (25–50 microM, n = 9). Granule cell EPSPs were decreased after focal application of CNQX to the molecular layer at a site close to the impaled granule cell (n = 5), whereas D-APV had no effect (n = 3). EPSPs also decreased after focal application of CNQX to the hilus, in two of four slices tested. The extracellularly recorded EPSP of granule cells was maximal in the inner molecular layer (n = 33), the site of the mossy cell axonal plexus. Severing the junction of the dentate gyrus and area CA3 blocked all spontaneous and evoked activity of dentate neurons without affecting burst discharges in area CA3a and CA3b (n = 6). None of the excitatory activity of any cell type was affected by cholinergic antagonists (atropine and mecamylamine, 25 microM each, n = 5; pirenzipine and dihydro-beta-erythroidine, 25 microM each, n = 5). The results suggest that there is a glutamatergic, AMPA/kainate receptor- mediated, excitatory pathway from area CA3 to the dentate gyrus in disinhibited slices. The pharmacological results, analyses of latency, as well as the known axonal projections of the sampled cells, suggest that the excitatory pathway begins within area CA3 and leads to granule cells via mossy cells. The data also suggest that dentate interneurons are excited by mossy cells, and possibly by pyramidal cells as well. (ABSTRACT TRUNCATED AT 400 WORDS)
Future rainfall variations reduce abundances of aboveground arthropods in model agroecosystems with different soil types

Climate change scenarios for Central Europe predict less frequent but heavier rainfalls and longer drought periods during the growing season. This is expected to alter arthropods in agroecosystems that are important as biocontrol agents, herbivores or food for predators (e.g. farmland birds). In a lysimeter facility (totally 18 3-m2-plots), we experimentally tested the effects of long-term past vs. prognosticated future rainfall variations (15% increased rainfall per event, 25% more dry days) according to regionalized climate change models from the Intergovernmental Panel on Climate Change (IPCC) on aboveground arthropods in winter wheat (Triticum aestivum L.) cultivated at three different soil types (calcaric phaeozem, calcic chernozem and gleyic phaeozem). Soil types were established 17 years and rainfall treatments one month before arthropod sampling; treatments were fully crossed and replicated three times. Aboveground arthropods were assessed by suction sampling, their mean abundances (± SD) differed between April, May and June with 20 ± 3 m-2, 90 ± 35 m-2 and 289 ± 93 individuals m-2, respectively. Averaged across sampling dates, future rainfall reduced the abundance of spiders (Araneae, -47%), cicadas and leafhoppers (Auchenorrhyncha, -39%), beetles (Coleoptera, -52%), ground beetles (Carabidae, -41%), leaf beetles (Chrysomelidae, -64%), spring tails (Collembola, -58%), flies (Diptera, -73%) and lacewings (Neuroptera, -73%) but increased the abundance of snails (Gastropoda, +69%). Across sampling dates, soil types had no effects on arthropod abundances. Arthropod diversity was neither affected by rainfall nor soil types. Arthropod abundance was positively correlated with weed biomass for almost all taxa; abundance of Hemiptera and of total arthropods was positively correlated with weed density. These detrimental effects of future rainfall varieties on arthropod taxa in wheat fields can potentially alter arthropod-associated agroecosystem services.
Expression and mutation of c-Kit in intracranial germ cell tumors: A single-centre retrospective study of 30 cases in China

Although primary central nervous system (CNS) germ cell tumors (GCTs) are one of the most treatable types of malignant brain tumor, a subset of patients remain resistant to standard chemotherapy. Gain-of-function mutations of the c-Kit gene, and KIT protein expression, have been observed in a number of GCTs, including testicular seminoma, ovarian dysgerminoma and mediastinal seminoma in various ethnic groups. Although a small number of studies have reported the role of c-Kit in CNS GCTs, few have focused on Chinese patients exhibiting CNS GCTs. In the present study, the frequency and location of c-Kit mutations and KIT protein expression levels in CNS GCTs were investigated in 30 patients, between January 1994 and October 2014. Immunohistochemical assays suggested that KIT protein expression was present in 59.1% patients (66.7% in males and 42.9% in females); however, no statistically significant correlation was identified between KIT protein expression and patient clinicopathological features. By performing PCR amplification and direct sequencing, 4 mutational hot spots of the c-Kit gene (exons 9, 11, 13 and 17) were examined, and c-Kit gene mutation was identified in 1/17 (5.9%) CNS germinoma cases. This mutation was located in exon 11 at codon 557–558 WK (Tryptophan-Lysine). No c-Kit gene mutations were detected in non-germinomatous GCTs. Imatinib, a tyrosine kinase inhibitor, may be an effective treatment against standard chemotherapy-resistant CNS germinoma patients exhibiting c-Kit mutations.
Anatomy and physiology of the thick-tufted layer 5 pyramidal neuron

The thick-tufted layer 5 (TTL5) pyramidal neuron is one of the most extensively studied neuron types in the mammalian neocortex and has become a benchmark for understanding information processing in excitatory neurons. By virtue of having the widest local axonal and dendritic arborization, the TTL5 neuron encompasses various local neocortical neurons and thereby defines the dimensions of neocortical microcircuitry. The TTL5 neuron integrates input across all neocortical layers and is the principal output pathway funneling information flow to subcortical structures. Several studies over the past decades have investigated the anatomy, physiology, synaptology, and pathophysiology of the TTL5 neuron. This review summarizes key discoveries and identifies potential avenues of research to facilitate an integrated and unifying understanding on the role of a central neuron in the neocortex.
Modular SRV Reinforcement Learning Architectures for Non-linear Control

This paper demonstrates the advantages of using a hybrid reinforcement–modular neural network architecture for non-linear control. Specifically, the method of ACTION - CRITIC reinforcement learning, modular neural networks, competitive learning and stochastic updating are combined. This provides an architecture able to both support temporal difference learning and probabilistic partitioning of the input space. The latter is formed with the aid of competitive learning algorithms, so as to ensure suitable partitioning of the experts in the modular network. Application of this methodology to the pole-balancing benchmark non-linear control problem demonstrates superior partitioning of the input space, bettering that of equivalent reinforcement networks; whilst avoiding the learning-to-learn nothing effect, as is often the case when performing gradient decent over problems requiring adaptation over long temporal dependencies.
Optimal Redistribution with Heterogeneous Preferences for Leisure

This paper examines the properties of the optimal nonlinear income tax when preferences are quasi–linear in leisure and individuals differ in their ability and their preferences for leisure. The government seeks to redistribute income. It can perfectly observe the level of endogenous income but cannot observe either ability or preferences. The heterogeneity of preferences leads to problems of comparability between individual utilities which challenge the design of redistributive schemes. We analyze the consequences of adopting a utilitarian social welfare function where the government is allowed to give different weights to individuals with different preferences. Under this particular social objective and given the quasi–linearity of preferences, we are able to obtain closed–form solutions for the marginal tax rates and to examine the progressivity of the tax system according to the weights used.
Learning distributed strategies for traffic control

In this paper, we cast the problem of managing traac ow in terms of a distributed collection of independent agents that adapt to their environment. We describe an evolutionary algorithm that learns strategies for lane selection, using local information, on a simulated highway that contains hundreds of agents. Experimental studies suggest that the learned controllers lead to better traac ow than ones constructed manually, and that the learned controllers are robust with respect to to blocked lanes and changes in the number of lanes on the highway.
Method for plasma chemical surface modification

The method is intended for plasma chemical surface modification of porous (polymeric and wood) materials, in particular for rendering such materials resistant to ignition and fire. It consists of preliminary plasma chemical surface treatment with cold technological plasma through electrical barrier discharge at atmospheric pressure and room temperature, check of the ion activity of the surface, correction of the ion activity of the impregnation solution containing fire retarding agents, impregnation through immersion, applying by brush or roller, or by spraying, and drying at a room temperature. The plasma chemical surface modification is performed by a trielectrode system constructed in a certain manner, so that two electrical discharges that are phase displaced in terms of ignition burnand assist each other in a common working space. The first of the electrodes (1) is electrically connected to the high voltage pole, the second electrode (15) is electrically connected to the earthedpole of the source (6) through the series connected reactive element (7) u condenser or choke, and the third electrode (4) is electrically connected directly to the earthed electrical pole of the source (6). The so formed electrode system is fed by a source of AC voltage with a frequency equal to or higher than 50/60 Hz.
F-term uplifting via consistent D-terms

The issue of fine-tuning necessary to achieve satisfactory degree of hierarchy between moduli masses, the gravitino mass and the scale of the cosmological constant has been revisited in the context of supergravities with consistent D-terms. We have studied (extended) racetrack models where supersymmetry breaking and moduli stabilisation cannot be separated from each other. We show that even in such cases the realistic hierarchy can be achieved on the expense of a single fine-tuning. The presence of two condensates changes the role of the constant term in the superpotential, W0, and solutions with small vacuum energy and large gravitino mass can be found even for very small values of W0. Models where D-terms are allowed to vanish at finite vevs of moduli fields - denoted ‘cancellable’ D-terms - and the ones where D-terms may vanish only at infinite vevs of some moduli - denoted ‘non-cancellable’ - differ markedly in their properties. It turns out that the tuning with respect to the Planck scale required in the case of cancellable D-terms is much weaker than in the case of non-cancellable ones. We have shown that, against intuition, a vanishing D-term can trigger F-term uplifting of the vacuum energy due to the stringent constraint it imposes on vacuum expectation values of charged fields. Finally we note that our models only rely on two dimensionful parameters: MP and W0.
Two-Log Increase in Sensitivity for Detection of Norovirus in Complex Samples by Concentration with Porcine Gastric Mucin Conjugated to Magnetic Beads

ABSTRACT Human histo-blood group antigens (HBGA) have been identified previously as candidate receptors for human norovirus (NOR). Type A, type H1, and Lewis HBGA in humans have been identified as major HBGA for NOR binding. We have found that pig stomach (gastric) mucin (PGM) contains blood group A, H1, and Lewis b HBGA and binds to multiple strains of NOR more broadly than do specific antibodies to NOR. Both genogroup I (GGI) and GGII NOR strains were recovered by PGM-conjugated magnetic beads. A fecal sample containing GGII NOR was detected at a dilution of 1:1,000,000 by the standard RNA extraction procedure, whereas NOR in a 1:100,000,000 dilution could be concentrated by PGM-conjugated magnetic beads and NOR in spiked food samples (e.g., oyster extract, strawberry, raspberry, and lettuce) was captured by PGM, thus minimizing the reverse transcription-PCR inhibitors in food and increasing sensitivity.
moosikMasheens: music, motion and narrative with young people who have complex needs

We present moosikMasheens, a novel system for musical expression by young people who have physical impairments or complex needs, playing music in a mixed ability group context. moosikMasheens consists of three electro-mechanical musical instruments that can be controlled via simple tablet computer-based interfaces. An adapted glockenspiel, guitar and a set of electro-mechanical drumsticks have the potential to provide feedback through many perceptual channels including sonic, visual, vibro-tactile and kinsaethetic. Through the use of both a priori theory and an extended participatory requirements analysis, the system has been designed for use by both teachers/workshop leaders and students, as this has previously been found to be the most common form of group musical interaction. The technical implementation of the system is outlined with an initial evaluation.
Creativity, Wisdom, and Our Evolutionary Future

In this paper I develop an integrative theoretical framework for understanding creativity, synthesizing themes and principles derived from mythology and philosophy, the physical and biological sciences, psychology, social and economic history, technology, and art and the study of beauty. I demonstrate how the creative process is integral to natural and human evolution and how human creativity builds upon creative evolution in nature. Further, I describe the relationship between creativity and both heightened future consciousness and wisdom, arguing that the latter two capacities clearly embody a creative dimension and form the leading edge of the future evolution of the human mind.
Quantifying Individual Variation in the Propensity to Attribute Incentive Salience to Reward Cues

If reward-associated cues acquire the properties of incentive stimuli they can come to powerfully control behavior, and potentially promote maladaptive behavior. Pavlovian incentive stimuli are defined as stimuli that have three fundamental properties: they are attractive, they are themselves desired, and they can spur instrumental actions. We have found, however, that there is considerable individual variation in the extent to which animals attribute Pavlovian incentive motivational properties (“incentive salience”) to reward cues. The purpose of this paper was to develop criteria for identifying and classifying individuals based on their propensity to attribute incentive salience to reward cues. To do this, we conducted a meta-analysis of a large sample of rats (N = 1,878) subjected to a classic Pavlovian conditioning procedure. We then used the propensity of animals to approach a cue predictive of reward (one index of the extent to which the cue was attributed with incentive salience), to characterize two behavioral phenotypes in this population: animals that approached the cue (“sign-trackers”) vs. others that approached the location of reward delivery (“goal-trackers”). This variation in Pavlovian approach behavior predicted other behavioral indices of the propensity to attribute incentive salience to reward cues. Thus, the procedures reported here should be useful for making comparisons across studies and for assessing individual variation in incentive salience attribution in small samples of the population, or even for classifying single animals.
Patterns of developmental dyslexia according to a multi-trace memory model of reading

Deux groupes d’enfants dyslexiques, caracterises soit par un deficit phonologique (PH) soit par un deficit visuo-attentionnel (VA), ont ete compares a des groupes controles de meme âge chronologique (CA) et de meme âge de lecture (RA). Toutes les performances en lecture des deux groupes de dyslexiques sont inferieures a celles des controles CA et equivalentes a celles des controles RA. Le groupe dyslexique VA lit moins bien les mots irreguliers que le groupe dyslexique PH alors que la performance en lecture de pseudo-mots est aussi faible dans les deux groupes. Ces resultats vont a l’encontre de l’hypothese de simple retard chez certains dyslexiques et remettent en cause les methodes courantes d’identification de sous-types de dyslexie. Ils sont en accord avec le modele multi-trace de lecture des mots polysyllabiques (Ans, Carbonnel & Valdois, 1998).
RNAi screening reveals requirement for host cell secretory pathway in infection by diverse families of negative-strand RNA viruses

Negative-strand (NS) RNA viruses comprise many pathogens that cause serious diseases in humans and animals. Despite their clinical importance, little is known about the host factors required for their infection. Using vesicular stomatitis virus (VSV), a prototypic NS RNA virus in the family Rhabdoviridae, we conducted a human genome-wide siRNA screen and identified 72 host genes required for viral infection. Many of these identified genes were also required for infection by two other NS RNA viruses, the lymphocytic choriomeningitis virus of the Arenaviridae family and human parainfluenza virus type 3 of the Paramyxoviridae family. Genes affecting different stages of VSV infection, such as entry/uncoating, gene expression, and assembly/release, were identified. Depletion of the proteins of the coatomer complex I or its upstream effectors ARF1 or GBF1 led to detection of reduced levels of VSV RNA. Coatomer complex I was also required for infection of lymphocytic choriomeningitis virus and human parainfluenza virus type 3. These results highlight the evolutionarily conserved requirements for gene expression of diverse families of NS RNA viruses and demonstrate the involvement of host cell secretory pathway in the process.
Long-Term Effects of a Parenting Preventive Intervention on Young Adults’ Attitudes Toward Divorce and Marriage

ABSTRACT This study examined whether the New Beginnings Program (NBP), a parenting-focused preventive intervention designed to reduce children’s postdivorce mental health problems, affected attitudes toward divorce and marriage in young adults whose mothers had participated 15 years earlier. Participants (M = 25.6 years; 50% female; 88% White) were from 240 families that had participated in a randomized experimental trial (NBP vs. literature control). Analyses of covariance showed that program effects on both types of attitudes were moderated by gender. Males in the NBP reported more positive attitudes toward marriage and less favorable attitudes toward divorce than males in the literature control.
Adaptive Neural Network Based Control of Noncanonical Nonlinear Systems

This paper presents a new study on the adaptive neural network-based control of a class of noncanonical nonlinear systems with large parametric uncertainties. Unlike commonly studied canonical form nonlinear systems whose neural network approximation system models have explicit relative degree structures, which can directly be used to derive parameterized controllers for adaptation, noncanonical form nonlinear systems usually do not have explicit relative degrees, and thus their approximation system models are also in noncanonical forms. It is well-known that the adaptive control of noncanonical form nonlinear systems involves the parameterization of system dynamics. As demonstrated in this paper, it is also the case for noncanonical neural network approximation system models. Effective control of such systems is an open research problem, especially in the presence of uncertain parameters. This paper shows that it is necessary to reparameterize such neural network system models for adaptive control design, and that such reparameterization can be realized using a relative degree formulation, a concept yet to be studied for general neural network system models. This paper then derives the parameterized controllers that guarantee closed-loop stability and asymptotic output tracking for noncanonical form neural network system models. An illustrative example is presented with the simulation results to demonstrate the control design procedure, and to verify the effectiveness of such a new design method.
Professional identity in relation to vocational teachers’ work: an identity-centred approach to professional development

ABSTRACT This paper reports a study on teachers’ professional identity and work in vocational education. The findings showed that vocational teachers’ work included vocational teaching within the school, developmental work, technology-enhanced work, professional duties outside the school, and educational duties within the school. Furthermore, the study revealed the harmonious and tensioned relationships between these elements of the work and teachers’ identities. Recognition of the nuanced nature of these relationships provides a perspective for promoting teachers’ professional development. From a practical perspective, there is a need to support vocational teachers’ identity work and the adoption of new technologies for their teaching. The findings also illuminate the emotionally imbued relationship between work and professional identity.