Miracle-dz/UniFAR-FTUs huggingface dataset:
Energy-Efficient Virtual Link Reconfiguration for Off-Peak Time

Energy consumption in Information and Communication Technology (ICT) is a large portion of total energy consumed in industrial countries. Virtualized Network Environment (VNE) has recently emerged as a solution to address the challenges of future Internet. It is essential to develop novel techniques to reduce VNE's energy consumption. In this paper, we propose an energy saving method that optimizes VNE's energy consumption during the off-peak time. This method reconfigures mapping for some of the embedded virtual links in the off-peak period. The proposed strategy enables providers to adjust the level of the reconfiguration, and accordingly control probable traffic disruptions due to the reconfiguration. This problem is formulated as a Binary Integer Linear Program (BILP). Since the defined BILP is NP-hard, a novel heuristic algorithm is also suggested. The proposed energy saving methods are evaluated over random VNE scenarios. The results confirm the defined solutions are able to save notable amounts of energy during off- peak period, while still accommodating off-peak traffic demands of involved virtual networks.
Foundations for peacebuilding and discursive peacekeeping: infusion and exclusion of conflict in Canadian public school curricula

Formal curriculum guidelines reflect prevailing understandings and political will, and help to shape the resources available for implemented curriculum. The understandings embodied in such public curriculum reinforce patterns of social violence and injustice, yet at the same time may provide diverse students with opportunities to develop commitment and critical citizenship capacity to handle social conflict. This paper examines the discourse about conflict, social diversity, and (in)justice in the mandated English Language Arts, Health, and Social Sciences curricula of three Canadian provinces. On one hand, all these curricula acknowledge the existence of bias and multiple viewpoints, and encode expectations for conflict management and critical inquiry skills, recognition of ethno‐cultural diversity, and awareness of international interdependence and justice concerns. Thus a significant proportion of the knowledge, skill, and pedagogy called for by international peace and conflict educators is already included in these curricula. At the same time, these themes are primarily represented in abstract terms emphasizing ‘Canadian’ ideals, instead of examining many actual instances of social conflict. Is this anti‐conflictual representation of social conflict a solid foundation for democratic peacebuilding, (and) or a gentle manner of peacekeeping through denial and indoctrination?
Kolaviron, a biflavonoid fraction from Garcinia kola, protects against isoproterenol-induced injury by mitigating cardiac dysfunction and oxidative stress in rats

Abstract Background: The aim of this study was to evaluate the cardioprotective effects of kolaviron (KV), a biflavonoid from Garcinia kola seeds, in rats intoxicated with isoproterenol chloride (ISO) while quercetin (QUE) served as standard. Methods: Forty-two male Wistar rats (180–200 g) were randomly divided into seven groups of six rats each. Group 1 served as control; group 2 received ISO (85 mg/kg subcutaneously); groups 3, 4 and 5 received ISO and KV1 [100 mg/kg orally (p.o.)], KV2 (200 mg/kg, p.o.) and QUE (25 mg/kg, p.o.), respectively; and groups 6 and 7 received QUE and KV2, respectively. Results: Administration of ISO caused significant (p<0.05) elevation of serum creatine phosphokinase, lactate dehydrogenase, alkaline phosphatase, alanine aminotransferase and aspartate aminotransferase by 2.2-, 1.9-, 2.1-, 1.9- and 1.7-fold, respectively, relative to controls, with a concomitant decrease in cardiac activities of these enzymes. Administration of ISO led to significant decrease (p<0.05) in the levels of cardiac superoxide dismutase, catalase, glutathione S-transferase, reduced glutathione and increase in malondialdehyde (MDA). Also, ISO-treated rats had significantly higher values of serum total cholesterol, triglycerides and low-density lipoprotein cholesterol relative to controls. Supplementation with KV2 and QUE caused significant elevation of cardiac antioxidant enzymes, normalized the marker enzymes and reduced MDA levels. Conclusions: KV protects against ISO-induced cardiotoxicity in vivo, suggesting its usefulness as a possible chemoprophylactic agent against cardiotoxic drugs.
Active but not consistent: dietary behaviour and the stages of change model

In Stages of Change studies on dietary fat, standard algorithms allocate many respondents to the maintenance stage and their stage allocations are not always supported by objective criteria. In defining the preparation stage standard instruments emphasise inactivity allied to confident intention to change. In contrast Lamb and Joshi's (1996) staging instrument emphasises inconsistent effort, and thereby allocates inconsistently active respondents to preparation when a standard instrument might place them in action or maintenance. In the current cross-sectional study 375 respondents completed a standard algorithm, the Lamb and Joshi instrument and a 24-hour recall food diary. They also gave judgements of their current weight and diet. Unlike the standard instrument, the Lamb and Joshi instrument: (a) allocated fewer respondents to action/maintenance, (b) discriminated key behavioural stages by percent fat in diet, and (c) captured non-linear discontinuities in the respondents’ weight and diet self-perceptions. Such discontinuities in the psychosocial processes are predicted by the transtheoretical model, and support the claim that its stages are categorically distinct rather than artificially isolated points on a continuum. Distinguishing between respondents who describe themselves as consistently active and those who describe themselves as inconsistently active may help to overcome some apparent problems in the application of the transtheoretical model to behavioural change.
A Comparison of Three Dementia Screening Instruments Administered by Telephone in China

Implementation of valid and efficient case-finding methods to screen for cognitive impairment is important for identifying people during the earliest stages of dementia. The Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE), Information-Memory-Concentration Test (IMCT), and Blessed-Roth Dementia Scale (BRDS) are assessment tools commonly used in China. This study investigated the usefulness of administering these scales by telephone. Subjects (N= 132: 74 females, 58 males) from Xuanwu Hospital, Capital University of Medical Sciences in Beijing, China were recruited for participation in this study; 132 collateral informants who accompanied the subjects to their appointments provided IQCODE and BRDS data. Senior neurologists using Diagnostic and Statistical Manual of Mental Disorders (DSM) criteria (American Psychiatric Publishing, 2000), patient history, physical examination, neuropsychological tests, neuroradiology, and laboratory tests made the dementia diagnoses. Blinded personnel administered the IQCODE, IMCT, and BRDS by telephone and face-to-face in the clinic in counter-balanced administration order. Independent subsamples of 20 subjects were selected for assessment of test-retest and inter-rater reliabilities of the telephone assessments. Correlations between the face-to-face and telephone administrations of the scales were good, ranging from . 80 to . 97. The administration order of assessment methods did not affect the results. Inter-rater and test-retest reliabilities were satisfactory. The sensitivity and specificity of each scale exceeded 80 percent, demonstrating scale validity and clinical utility. The results support reliable and valid administration of these dementia assessments in person or over the telephone. The appropriate selection of assessment instruments is dependent upon the characteristics of the patient population and the intended use of the results. Use of telephone assessments may provide a valid and efficient method to screen elderly people for early detection of dementia symptoms and to monitor the effectiveness of treatment.
Where the Wild Warnings Are: Root Causes of Chrome HTTPS Certificate Errors

HTTPS error warnings are supposed to alert browser users to network attacks. Unfortunately, a wide range of non-attack circumstances trigger hundreds of millions of spurious browser warnings per month. Spurious warnings frustrate users, hinder the widespread adoption of HTTPS, and undermine trust in browser warnings. We investigate the root causes of HTTPS error warnings in the field, with the goal of resolving benign errors. We study a sample of over 300 million errors that Google Chrome users encountered in the course of normal browsing. After manually reviewing more than 2,000 error reports, we developed automated rules to classify the top causes of HTTPS error warnings. We are able to automatically diagnose the root causes of two-thirds of error reports. To our surprise, we find that more than half of errors are caused by client-side or network issues instead of server misconfigurations. Based on these findings, we implemented more actionable warnings and other browser changes to address client-side error causes. We further propose solutions for other classes of root causes.
53BP1 contributes to survival of cells irradiated with X‐ray during G1 without Ku70 or Artemis

Ionizing radiation (IR) induces a variety of DNA lesions. The most significant lesion is a DNA double‐strand break (DSB), which is repaired by homologous recombination or nonhomologous end joining (NHEJ) pathway. Since we previously demonstrated that IR‐responsive protein 53BP1 specifically enhances activity of DNA ligase IV, a DNA ligase required for NHEJ, we investigated responses of 53BP1‐deficient chicken DT40 cells to IR. 53BP1‐deficient cells showed increased sensitivity to X‐rays during G1 phase. Although intra‐S and G2/M checkpoints were intact, the frequency of isochromatid‐type chromosomal aberrations was elevated after irradiation in 53BP1‐deficient cells. Furthermore, the disappearance of X‐ray‐induced γ‐H2AX foci, a marker of DNA DSBs, was prolonged in 53BP1‐deficient cells. Thus, the elevated X‐ray sensitivity in G1 phase cells was attributable to repair defect for IR‐induced DNA‐damage. Epistasis analysis revealed that 53BP1 plays a role in a pathway distinct from the Ku‐dependent and Artemis‐dependent NHEJ pathways, but requires DNA ligase IV. Strikingly, disruption of the 53BP1 gene together with inhibition of phosphatidylinositol 3‐kinase family by wortmannin completely abolished colony formation by cells irradiated during G1 phase. These results demonstrate that the 53BP1‐dependent repair pathway is important for survival of cells irradiated with IR during the G1 phase of the cell cycle.
Neuronal Progenitor Cells Derived from the Anterior Subventricular Zone of the Neonatal Rat Forebrain Continue to Proliferatein Vitroand Express a Neuronal Phenotype

A discrete area of the anterior part of the subventricular zone, or SVZa, of the postnatal forebrain is composed of progenitor cells that are dissimilar to those elsewhere in the CNS. In vivo SVZa progenitor cells retain the ability for division, even though they are phenotypically neurons. To characterize further the properties of SVZa cells, we have analyzed their characteristics in vitro using cell-type specific antibodies and their proliferative capacity by the incorporation of bromodeoxyuridine. At 2 h in vitro, as well as after 1 day in vitro, virtually all SVZa cells isolated from the neonatal forebrain express TuJ1, an antibody that recognizes neuron-specific tubulin, and are GFAP-negative. Likewise, the preponderance of SVZa cells express the neuron-specific markers N-CAM and MAP-2 when examined after 1 day in culture. The majority of SVZa cells cultured for as long as 8 days also possessed a neuronal phenotype. In addition, process-bearing TuJ1-positive SVZa cells continued to proliferate throughout the entire culture period. Thus, the neuronal progenitor cells of the SVZa constitute a unique cell population with characteristics distinct from the cells of other germinal zones.
Saccade learning with concurrent cortical and subcortical basal ganglia loops

The Basal Ganglia (BG) is a central structure involved in multiple cortical and subcortical loops. Some of these loops are believed to be responsible for saccade target selection. We study here how the very specific structural relationships of these saccadic loops can affect the ability of learning spatial and feature-based tasks. We propose a model of saccade generation with reinforcement learning capabilities based on our previous BG and superior colliculus models. It is structured around the interactions of two parallel cortico-basal loops and one tecto-basal loop. The two cortical loops separately deal with spatial and non-spatial information to select targets in a concurrent way. The subcortical loop is used to make the final target selection leading to the production of the saccade. These different loops may work in concert or disturb each other regarding reward maximization. Interactions between these loops and their learning capabilities are tested on different saccade tasks. The results show the ability of this model to correctly learn basic target selection based on different criteria (spatial or not). Moreover the model reproduces and explains training dependent express saccades toward targets based on a spatial criterion. Finally, the model predicts that in absence of prefrontal control, the spatial loop should dominate.
Sleep Loss Produces False Memories

People sometimes claim with high confidence to remember events that in fact never happened, typically due to strong semantic associations with actually encoded events. Sleep is known to provide optimal neurobiological conditions for consolidation of memories for long-term storage, whereas sleep deprivation acutely impairs retrieval of stored memories. Here, focusing on the role of sleep-related memory processes, we tested whether false memories can be created (a) as enduring memory representations due to a consolidation-associated reorganization of new memory representations during post-learning sleep and/or (b) as an acute retrieval-related phenomenon induced by sleep deprivation at memory testing. According to the Deese, Roediger, McDermott (DRM) false memory paradigm, subjects learned lists of semantically associated words (e.g., “night”, “dark”, “coal”,…), lacking the strongest common associate or theme word (here: “black”). Subjects either slept or stayed awake immediately after learning, and they were either sleep deprived or not at recognition testing 9, 33, or 44 hours after learning. Sleep deprivation at retrieval, but not sleep following learning, critically enhanced false memories of theme words. This effect was abolished by caffeine administration prior to retrieval, indicating that adenosinergic mechanisms can contribute to the generation of false memories associated with sleep loss.
Instant Messaging and Interruption: Influence of Task Type on Performance

We describe research on the effects of instant messaging (IM) on ongoing computing tasks. We present a study that builds on earlier work exploring the influence of sending notifications at different times and the kinds of tasks that are particularly susceptible to interruption. This work investigates alternative hypotheses about the nature of disruption for a list evaluation task, an activity we had identified as being particularly costly to interrupt. Our findings replicate earlier work, showing the generally harmful effects of IM, and further show that notifications are more disruptive for fast, stimulus-driven search tasks than for slower, more effortful semantic-based search tasks.
Approaching Sehnsucht (Life Longings) from a Life-Span Perspective: The Role of Personal Utopias in Development

Sehnsucht (life longings) refers to thoughts and feelings about missing something in life that would make it complete or perfect. Using a life-span–theoretical approach, we posit that life longings have important developmental functions, including giving directionality for life planning and helping to cope with loss and important, yet unattainable wishes by pursuing them in one's imagination. This article presents a life-span–theoretical conceptualization of Sehnsucht recently introduced by Paul B. Baltes and colleagues (Baltes, in press; Scheibe, Freund, & Baltes, 2008) and reviews first empirical research conducted in this framework. The review addresses lay conceptions of Sehnsucht and the construct's distinction from already existing, well-articulated constructs (goals, regrets, ideal self), the functions of life longings for development, and age-related differences across adulthood.
Hear nothing, do nothing: The role of word of mouth in the decision-making of older consumers

Abstract In some product categories, older consumers (aged 65+) tend to be more brand loyal, have smaller consideration sets and defer purchase more than younger consumers. This conservative behaviour may arise, in part, because older people are more socially isolated and thus receive less social influence relating to product options. In this multi-study research, the volume of word of mouth (WOM) is used as an indicator of social influence. The WOM received by men and women falls substantially beyond age 65, indicating that a deficit in advice may be part of the explanation for conservative decision-making. To test this proposition, the duration of customer tenure of the current brand (how long the respondent has been a customer) is used as a measure of purchase deferral and, as predicted, tenure is longer when less WOM is received. This evidence indicates that some older consumers experience a degree of social isolation, which affects their decision-making. In marketing and social policy, there is a need to promote procedures, technologies and institutions that help older people to connect with others.
Contradictions and Promise for End-of-Life Communication among Family and Friends: Death over Dinner Conversations

The free, open-access website called “Let’s Get Together and Talk about Death”, or Death over Dinner (DoD), provides resources for initiating end-of-life conversations with family and friends by taking the frightening—talking about death—and transforming it into the familiar—a conversation over dinner. This qualitative, descriptive study uses grounded theory and thematic analysis to answer the following research question: How do friend and family groups communicate about death and dying in DoD conversations? To answer this question, 52 dinner groups were recruited and conversations were conducted, which consisted of a facilitator and volunteers. The facilitators were the researchers or research assistants who allowed dinner participants to control the conversation and identify topics of interest, and participants were free to share as much or as little as they wanted. Our analysis revealed that family and friend groups communicated similarly in that they talked about similar topics and used similar communication strategies to discuss those topics. Three major themes emerged: Desire for a good death, which juxtaposed people’s perceptions of a “dreaded” death with those of a “desirable” death; tactics for coping, which consisted of the subthemes of humour to diffuse tension or deflect discomfort, spiritual reassurance, and topic avoidance; and topics that elicit fear or uncertainty, which consisted of the subthemes of organ and whole-body donation, hospice and palliative care, wills and advance directives. Ultimately, however, participants felt their experiences were positive and DoD shows promise as a tool for families to engage in end-of-life conversations.
Becoming Who We Are: A Theoretical Explanation of Gendered Social Structures and Social Networks that Shape Adolescent Interpersonal Aggression

A conceptualization of gendered interpersonal aggression that is grounded in the social ecological framework is presented to explicate factors in adolescents' gendered environments that give rise to aggression and victimization. The focus is on gendered social structures and social networks. Our framework for prevention suggests that violence prevention requires that we move our culture from one that continually recreates gendered structures that reinforce power and authority as masculine and that confer opportunities and constraints in ways that favor men over women. It will require deliberate action to legitimize the feminine in our culture and develop laws and practices that abolish gender inequities.
Depression and Risk of Mortality in People with Diabetes Mellitus: A Systematic Review and Meta-Analysis

Objective To examine the association between depression and all-cause and cardiovascular mortality in people with diabetes by systematically reviewing the literature and carrying out a meta-analysis of relevant longitudinal studies. Research Design and Methods PUBMED and PSYCINFO were searched for articles assessing mortality risk associated with depression in diabetes up until August 16, 2012. The pooled hazard ratios were calculated using random-effects models. Results Sixteen studies met the inclusion criteria, which were pooled in an overall all-cause mortality estimate, and five in a cardiovascular mortality estimate. After adjustment for demographic variables and micro- and macrovascular complications, depression was associated with an increased risk of all-cause mortality (HR = 1.46, 95% CI = 1.29–1.66), and cardiovascular mortality (HR = 1.39, 95% CI = 1.11–1.73). Heterogeneity across studies was high for all-cause mortality and relatively low for cardiovascular mortality, with an I-squared of respectively 78.6% and 39.6%. Subgroup analyses showed that the association between depression and mortality not significantly change when excluding three articles presenting odds ratios, yet this decreased heterogeneity substantially (HR = 1.49, 95% CI = 1.39–1.61, I-squared = 15.1%). A comparison between type 1 and type 2 diabetes could not be undertaken, as only one study reported on type 1 diabetes specifically. Conclusions Depression is associated with an almost 1.5-fold increased risk of mortality in people with diabetes. Research should focus on both cardiovascular and non-cardiovascular causes of death associated with depression, and determine the underlying behavioral and physiological mechanisms that may explain this association.
Architectural characteristics of muscle in black and white college football players.

PURPOSE The purpose of this study was to determine whether architectural characteristics of skeletal muscle differ by race. METHODS Skeletal muscle architectural characteristics and body composition were studied in 13 black and 31 white male college football players. Fat-free mass (FFM) and percentage body fat (% fat) were determined by hydrostatic weighing technique. Muscle thickness (MTH) was measured by B-mode ultrasound at 13 anatomical sites. Isolated MTH and muscle pennation angle (PANG) of the triceps long head, vastus lateralis, and gastrocnemius medialis muscles were measured by ultrasound, and fascicle length was estimated. RESULTS There were no significant differences between blacks and whites in isolated MTH, PANG, and fascicle length in the triceps long head, vastus lateralis, and gastrocnemius medialis muscles. On average, % fat and FFM of black and white football players were 18.8 +/- 4.6% and 17.2 +/- 5.6% for % fat, and 89.9 +/- 15.6 kg and 89.1 +/- 10.4 kg for FFM, respectively. Blacks had a significantly greater, 30%-quadriceps (P < 0.05), 50%-hamstrings (P < 0.05), biceps (P < 0.01), and abdomen (P < 0.01) MTH than those of whites. Standing height and body weight were similar between blacks and whites, but the ratio of leg length to standing height was significantly greater in blacks compared with whites. CONCLUSIONS It appears that although there may be race differences in anatomical stature, muscle architecture is likely independent of race.