Miracle-dz/UniFAR-FTUs huggingface dataset:
Photodynamic Therapy and Skin Appendage Disorders: A Review

Photodynamic therapy (PDT) is a noninvasive treatment that utilizes light treatment along with application of a photosensitizing agent. In dermatology, PDT is commonly used and approved for the treatment of oncological conditions such as actinic keratosis, Bowen disease and superficial basal cell carcinoma. In the last 2 decades however, PDT has also been used for the treatment of several nonneoplastic dermatological diseases. The present review summarizes published data on PDT application in skin appendage disorders. Our literature review shows that: (a) PDT may be a suitable treatment for acne, folliculitis decalvans, hidradenitis suppurativa, nail diseases, and sebaceous hyperplasia; (b) there is a lack of agreement on PDT features (type, concentrations and incubation period of used substances, number and frequency of PDT sessions, optimal parameters of light sources, and patient characteristics [e.g., failure to previous treatments, disease severity, body surface area involved, etc.] which should guide PDT use in these diseases); (c) further research is needed to establish international guidelines helping dermatologists to choose PDT for the right patient at the right time.
Memory Hierarchy Characterization of NoSQL Applications through Full-System Simulation

In this work, we conduct a detailed memory characterization of a representative set of modern data-management software (Cassandra, MongoDB, OrientDB and Redis) running an illustrative NoSQL benchmark suite (YCSB). These applications are widely popular NoSQL databases with different data models and features such as in-memory storage. We compare how these data-serving applications behave with respect to other well-known benchmarks, such as SPEC CPU2006, PARSEC and NAS Parallel Benchmark. The methodology employed for evaluation relies on state-of-the-art full-system simulation tools, such as gem5. This allows us to explore configurations unattainable using performance monitoring units in actual hardware, being able to characterize memory properties. The results obtained suggest that NoSQL application behavior is not dissimilar to conventional workloads. Therefore, some of the optimizations present in state-of-the-art hardware might have a direct benefit. Nevertheless, there are some common aspects that are distinctive of conventional benchmarks that might be sufficiently relevant to be considered in architectural design. Strikingly, we also found that most database engines, independently of aspects such as workload or database size, exhibit highly uniform behavior. Finally, we show that different data-base engines make highly distinctive demands on the memory hierarchy, some being more stringent than others.
Sequential neuromodulation of Hebbian plasticity offers mechanism for effective reward-based navigation

Spike timing-dependent plasticity (STDP) is under neuromodulatory control, which is correlated with distinct behavioral states. Previously, we reported that dopamine, a reward signal, broadens the time window for synaptic potentiation and modulates the outcome of hippocampal STDP even when applied after the plasticity induction protocol (Brzosko et al., 2015). Here, we demonstrate that sequential neuromodulation of STDP by acetylcholine and dopamine offers an efficacious model of reward-based navigation. Specifically, our experimental data in mouse hippocampal slices show that acetylcholine biases STDP toward synaptic depression, whilst subsequent application of dopamine converts this depression into potentiation. Incorporating this bidirectional neuromodulation-enabled correlational synaptic learning rule into a computational model yields effective navigation toward changing reward locations, as in natural foraging behavior. Thus, temporally sequenced neuromodulation of STDP enables associations to be made between actions and outcomes and also provides a possible mechanism for aligning the time scales of cellular and behavioral learning. DOI: http://dx.doi. org/10.7554/eLife.27756. 001
Wood Fiber Reinforced Polyethylene and Polypropylene Composites with High Modulus and Impact Strength

Wood plastic composite with high modulus and impact strength were manufactured by combining polyethylene (PE) or polypropylene (PP) with wood fiber (WF) using twin-screw extruder techniques. The advantage of using low melt viscosity polymer matrices is that it enhances the modulus and reduces the overall viscosity of the system. SEM analysis of the composites indicates that the polymer molecules penetrate into the vessels and cracks of the cellulose fiber, which decreases the number of voids and produces a higher density composite with improved mechanical performance. The addition of maleic anhydride-grafted polyolefin as a compatibilizer improves the level of adhesion between the wood fiber and the polyolefin matrix. The impact strength of the composites with compatibilizer is 60% higher than those without. Young's moduli of WF/PE and WF/PP with compatibilizer were 4.4 and 5.4 GPa, respectively, meanwhile the impact strengths of WF/PE and WF/PP were 44 and 24J/m, where the WF content was 50wt%.
Visceral Adiposity Predicts Severity of Acute Pancreatitis.

OBJECTIVES The aim of this study was to determine the association of visceral adiposity with severe outcomes in acute pancreatitis (AP). METHODS This retrospective study included consecutive patients with AP admitted to a tertiary care hospital between January 2010 and January 2015 who underwent a computed tomography scan. The visceral adipose tissue (VAT) volume was estimated using the method of Linder and colleagues. Multivariable logistic regression analysis was conducted to assess VAT as a predictor of severe AP compared with other validated predictors of severity. RESULTS Five hundred and seventy four patients were admitted during the study period, of which 252 had a computed tomography scan available. Patients with severe AP had a larger VAT area compared with those with mild or moderate AP (mean: 184.9 cm vs 79.9 cm, P = 0.006). Patients who developed multisystem organ failure or had acute necrotic collections had a larger VAT area than those who did not (150.6 cm vs 91.0 cm, P = 0.004 and 174.0 cm vs 91.9 cm, P = 0.003, respectively). Visceral adipose tissue area demonstrated superior discrimination of severe AP compared with other severity predictors. CONCLUSIONS Increased VAT area is a strong predictor of severe pancreatitis, necrosis, and multisystem organ failure.
A Model for Transposition of the Colistin Resistance Gene mcr-1 by ISApl1

ABSTRACT Analysis of mcr-1-containing sequences identified a common ∼2,607-bp DNA segment that in many cases is flanked on one or both ends by ISApl1. We present evidence that mcr-1 is mobilized by an ISApl1 composite transposon which has, in some cases, subsequently lost one or both copies of ISApl1. We also show that mcr-1 can be mobilized in some circumstances by a single upstream copy of ISApl1 in conjunction with the remnants of a downstream ISApl1.
Tree-Based BLSTM for Mathematical Expression Recognition

In this study, we extend the chain-structured BLSTM to tree structure topology and apply this new network model for online math expression recognition. The proposed system addresses the recognition task as a graph building problem. The input expression is a sequence of strokes from which an intermediate graph is derived using temporal and spatial relations among strokes. In this graph, a node corresponds to a stroke and an edge denotes the relationship between a pair of strokes. Then several trees are derived from the graph and labeled with Tree-based BLSTM. The last step is to merge these labeled trees to build an admissible label graph (LG) modeling 2-D formulas uniquely. The proposed system achieves competitive results in online math expression recognition domain.
Suicide Mortality Trends in Four Provinces of Iran with the Highest Mortality, from 2006-2016

Background: Suicide is a major cause of unnatural deaths in the world. Its incidence is higher in western provinces of Iran. So far, there has not been any time series analysis of suicide in western provinces. The purpose of this study was to analyze suicide mortality data from 2006 to 2016 as well as to forecast the number of suicides for 2017 in four provinces of Iran (Ilam, Kermanshah and Lorestan and Kohgiluyeh and Boyer-Ahmad). Study design: Descriptive-analytic study. Methods: Data were analyzed by time series analysis using R software. Three automatic methods (Auto.arima, ETS (Error Transitional Seasonality) and time series linear model (TSLM)) were fitted on the data. The best model after cross validation according to the mean absolute error measure was selected for forecasting. Results: Totally, 7004 suicidal deaths occurred of which, 4259 were male and 2745 were female. The mean age of the study population was (32.05 ± 15.48 yr). Hanging and self-immolation were the most frequent types of suicide in men and women, respectively. The maximum and minimum number of suicides was occurred in July and August as well as January respectively. Conclusions: It is suggested that intervention measures should be designed in order to decrease the suicide rate particularly in the age group of 15-29 yr, and implemented as a pilot study, especially in these four provinces of Iran, which have a relatively high suicide rate.
Cervical Cancer Screening Preferences Among Trans-Masculine Individuals: Patient-Collected Human Papillomavirus Vaginal Swabs Versus Provider-Administered Pap Tests.

PURPOSE Trans-masculine (TM, i.e., persons who have a masculine spectrum gender identity, but were assigned female sex at birth) individuals face disparities in cervical cancer screening rates compared to cisgender women. Some unique barriers to screening in this population are specific to Pap tests. Introduction of self-collected frontal (i.e., vaginal) swabs for human papillomavirus (HPV) testing as a screening strategy may obviate these barriers. This study elucidates cervical cancer screening preferences among TM individuals. METHODS TM individuals participated in in-depth interviews (n = 31) and online surveys (n = 32) to explore perceptions and experiences regarding cervical cancer screening, including the acceptability of self-collected frontal HPV swabs for cervical cancer screening compared to provider-administered Pap tests. Provider-collected frontal HPV swab acceptability was also explored. RESULTS Most TM individuals (94% in-person and 91% online participants) preferred either the self- or provider-collected frontal HPV swab to the Pap test. Participants perceived self- and provider-collected frontal HPV swabs to be less invasive, provoke less gender discordance, and promote a greater sense of agency compared to Pap tests. However, some participants expressed concern about HPV swab accuracy and, regarding the self-collected swab, discomfort about the need to engage with genitals they may not want to acknowledge. Individuals who reported positive provider relationships found Pap tests and provider-collected frontal swabs more acceptable than those who did not. CONCLUSION Frontal HPV swabs have the potential to promote regular cervical cancer screening among TM individuals and to narrow screening disparities. Work is ongoing to establish swab accuracy and develop shared decision-making tools.
Production and Characterisation of Ceramic Foams from Industrial Solid Waste

This work has as objective to produce and to characterize ceramic foams from glass bottles, sludge from sewage treatment station and graphite (0 - 10 wt%) as a foaming agent. Different compositions were formulated and prepared to obtain materials with controlled porosity for applications where thermal insulation is the main requirement. The raw materials of the prepared compositions were mixed and uniaxially pressed at 40 MPa. Subsequently, the prepared samples were dried and fired at different temperatures (800 - 950 oC) for 30 minutes, respectively. The raw materials and obtained ceramic foams were characterized in terms of their chemical, morphological, thermal and mechanical properties. The results showed that it is possible to produce ceramic foams for thermal insulation with optimized compositions containing 90 vol% glass and 10 vol% sludge with addition of 10 wt% graphite. The ceramic foams showed porosities between 40 and 70 %, thermal conductivity from 0.101 to 0.175 W/mK and compressive strength between 6.4 and 12.5 MPa.
The health outcomes of human offspring conceived by assisted reproductive technologies (ART)

Concerns have been raised about the health and development of children conceived by assisted reproductive technologies (ART) since 1978. Controversially, ART has been linked with adverse obstetric and perinatal outcomes, an increased risk of birth defects, cancers, and growth and development disorders. Emerging evidence suggests that ART treatment may also predispose individuals to an increased risk of chronic ageing related diseases such as obesity, type 2 diabetes and cardiovascular disease. This review will summarize the available evidence on the short-term and long-term health outcomes of ART singletons, as multiple pregnancies after multiple embryos transfer, are associated with low birth weight and preterm delivery, which can separately increase risk of adverse postnatal outcomes, and impact long-term health. We will also examine the potential factors that may contribute to these health risks, and discuss underlying mechanisms, including epigenetic changes that may occur during the preimplantation period and reprogram development in utero, and adult health, later in life. Lastly, this review will consider the future directions with the view to optimize the long-term health of ART children.
GATA3 expression in triple‐negative breast cancers

GATA‐binding protein 3 (GATA3) is a well‐studied transcription factor found to be essential in the development of luminal breast epithelium and has been identified in a variety of tumour types, including breast and urothelial carcinomas, making it a useful immunohistochemistry marker in the diagnosis of both primary and metastatic disease.
The complete mitochondrial genome of the Anabas testudineus (Perciformes, Anabantidae) and its comparison with other related fish species

Abstract In the present study, the complete mitochondrial genome sequence of Anabas testudineusis reported using PGM sequencer (Ion Torrent, Life Technologies, La Jolla, CA). The complete mitogenome of climbing perch, A. testudineusis obtained by the de novo sequences assembly of genomic reads using the Torrent Mapping Alignment Program (TMAP), which is 16 603 bp in length. The mitogenome of A. testudineus composed of 13 protein- coding genes, two rRNA, and 22 tRNAs. Here, 20 tRNAs genes showed typical clover leaf model, and D-Loop as the control region along with gene order and organization, being closely similar to Osphronemidae and most of other Perciformes fish mitogenomes of NCBI databases. The mitogenome in the present study has 99% similarity to the complete mitogenome sequence of earlier reported A. testudineus. The phylogenetic analysis of Anabantidae depicted that their mitogenomes are closely related to each other. The complete mitogenome sequence of A. testudineus would be helpful in understanding the population genetics, phylogenetics, and evolution of Anabantidae.
Behavior of Natural Fiber in Stone Matrix Asphalt Mixtures Using Two Design Methods

AbstractThe technology of asphalt materials and mixtures has evolved in the last four decades in Europe and North America. For the surface layer, there has been an increase in the use of more resistant and durable asphalt mixtures, such as mixtures with discontinuous graduation, e.g., stone matrix asphalt (SMA),which is a gap graded mixture containing 70–80% coarse aggregate of total aggregate mass, 6–7% of binder, 8–12% of filler, and about 0.3–0.5% of fiber. The fibers hold the binder in the mixture at high temperature and prevent drainage during production, transportation, and construction. This research presents a study of the behavior of natural fibers (coconut and cellulose fibers) on SMA mixtures using two different design methods (Marshall and Superpave). The specimens were tested using several common laboratory test procedures: draindown test, indirect tensile strength, resilient modulus, fatigue life, and moisture susceptibility. The draindown test results clearly revealed that coconut fiber can.
Spearcons for Patient Monitoring: Laboratory Investigation Comparing Earcons and Spearcons

Objective We compared the effectiveness of single-tone earcons versus spearcons in conveying information about two commonly monitored vital signs: oxygen saturation and heart rate. Background The uninformative nature of many medical alarms—and clinicians’ lack of response to alarms—is a widespread problem that can compromise patient safety. Auditory displays, such as earcons and spearcons (speech-based earcons), may help clinicians maintain awareness of patients’ well-being and reduce their reliance on alarms. Earcons are short abstract sounds whose properties represent different types and levels of information, whereas spearcons are time-compressed spoken phrases that directly state their meaning. Listeners might identify patient vital signs more accurately with spearcons than with earcons. Method In Experiment 1 we compared how accurately 40 nonclinician participants using either (a) single-tone earcons differentiated by timbre and tremolo or (b) Cantonese spearcons recorded using a female Cantonese voice could identify both oxygen saturation and heart rate levels. In Experiment 2 we tested the identification performance of six further nonclinician participants with spearcons recorded using a male Cantonese voice. Results In Experiment 1, participants using spearcons identified both vital signs together more accurately than did participants using earcons. Participants using Cantonese spearcons also learned faster, completed trials faster, identified individual vital signs more accurately, and felt greater ease and more confident when identifying oxygen saturation levels. Experiment 2 verified the previous findings with male-voice Cantonese spearcons. Conclusion Participants identified vital signs more accurately using spearcons than with the single-tone earcons. Application Spearcons may be useful for patient monitoring in situations in which intermittently presented information is desirable.
Review on Factors Influencing Physician Guideline Adherence in Cardiology

Cardiovascular disease is the most common cause of death in Western countries. Physician adherence to guidelines is often suboptimal, resulting in impaired patient outcome and prognosis. Multiple studies have been conducted to evaluate patterns and the influencing factors of patient adherence, but little is known about factors influencing physician guideline adherence. This review aims to identify factors influencing physician guideline adherence relevant to cardiology and to provide insights and suggestions for future improvement. Physician adherence was measured as adherence to standard local medical practice and applicable guidelines. Female gender and older age had a negative effect on physician guideline adherence. In addition, independent of the type of heart disease, physicians without cardiologic specialization were linked to physician noncompliance. Also, guideline adherence in primary care centers was at a lower level compared with secondary or tertiary care centers. The importance of guideline adherence increases as patients age, and complex diseases and comorbidity arise. Appropriate resources and interventions, taking important factors for nonadherence in account, are necessary to improve guideline adoption and adherence in every level of the chain. This in turn should improve patient outcome.
Hematoma clearance as a therapeutic target in intracerebral hemorrhage: From macro to micro

Despite the absence of an intervention shown to improve outcomes in intracerebral hemorrhage, preclinical work has led to a greater understanding of the pathologic pathways of brain injury. Methods targeting hematoma clearance through both macroscopic (surgical) and microscopic (endogenous phagocytosis) means are currently under investigation, with multiple clinical trials ongoing. Macroscopic methods for removal involve both catheter- and endoscope-based therapies to remove the hematoma through minimally invasive surgery. Microscopic methods targeting hematoma clearance involve augmenting endogenous clearance pathways for red blood cells and altering the balance between phagocytosis and red blood cell lysis with the release of potentially harmful constituents (e.g. hemoglobin and iron) into the extracellular space.
A Recombinant Respiratory Syncytial Virus Vaccine Candidate Attenuated by a Low-Fusion F Protein Is Immunogenic and Protective against Challenge in Cotton Rats

ABSTRACT Although respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infections in infants, a safe and effective vaccine is not yet available. Live-attenuated vaccines (LAVs) are the most advanced vaccine candidates in RSV-naive infants. However, designing an LAV with appropriate attenuation yet sufficient immunogenicity has proven challenging. In this study, we implemented reverse genetics to address these obstacles with a multifaceted LAV design that combined the codon deoptimization of genes for nonstructural proteins NS1 and NS2 (dNS), deletion of the small hydrophobic protein (ΔSH) gene, and replacement of the wild-type fusion (F) protein gene with a low-fusion RSV subgroup B F consensus sequence of the Buenos Aires clade (BAF). This vaccine candidate, RSV-A2-dNS-ΔSH-BAF (DB1), was attenuated in two models of primary human airway epithelial cells and in the upper and lower airways of cotton rats. DB1 was also highly immunogenic in cotton rats and elicited broadly neutralizing antibodies against a diverse panel of recombinant RSV strains. When vaccinated cotton rats were challenged with wild-type RSV A, DB1 reduced viral titers in the upper and lower airways by 3.8 log10 total PFU and 2.7 log10 PFU/g of tissue, respectively, compared to those in unvaccinated animals (P < 0.0001). DB1 was thus attenuated, highly immunogenic, and protective against RSV challenge in cotton rats. DB1 is the first RSV LAV to incorporate a low-fusion F protein as a strategy to attenuate viral replication and preserve immunogenicity. IMPORTANCE RSV is a leading cause of infant hospitalizations and deaths. The development of an effective vaccine for this high-risk population is therefore a public health priority. Although live-attenuated vaccines have been safely administered to RSV-naive infants, strategies to balance vaccine attenuation with immunogenicity have been elusive. In this study, we introduced a novel strategy to attenuate a recombinant RSV vaccine by incorporating a low-fusion, subgroup B F protein in the genetic background of codon-deoptimized nonstructural protein genes and a deleted small hydrophobic protein gene. The resultant vaccine candidate, DB1, was attenuated, highly immunogenic, and protective against RSV challenge in cotton rats.