Miracle-dz/UniFAR-FTUs huggingface dataset:
Efficient Neural Audio Synthesis

Sequential models achieve state-of-the-art results in audio, visual and textual domains with respect to both estimating the data distribution and generating high-quality samples. Efficient sampling for this class of models has however remained an elusive problem. With a focus on text-to-speech synthesis, we describe a set of general techniques for reducing sampling time while maintaining high output quality. We first describe a single-layer recurrent neural network, the WaveRNN, with a dual softmax layer that matches the quality of the state-of-the-art WaveNet model. The compact form of the network makes it possible to generate 24kHz 16-bit audio 4x faster than real time on a GPU. Second, we apply a weight pruning technique to reduce the number of weights in the WaveRNN. We find that, for a constant number of parameters, large sparse networks perform better than small dense networks and this relationship holds for sparsity levels beyond 96%. The small number of weights in a Sparse WaveRNN makes it possible to sample high-fidelity audio on a mobile CPU in real time. Finally, we propose a new generation scheme based on subscaling that folds a long sequence into a batch of shorter sequences and allows one to generate multiple samples at once. The Subscale WaveRNN produces 16 samples per step without loss of quality and offers an orthogonal method for increasing sampling efficiency.
Contextualizing Privacy Decisions for Better Prediction (and Protection)

Modern mobile operating systems implement an ask-on-first-use policy to regulate applications' access to private user data: the user is prompted to allow or deny access to a sensitive resource the first time an app attempts to use it. Prior research shows that this model may not adequately capture user privacy preferences because subsequent requests may occur under varying contexts. To address this shortcoming, we implemented a novel privacy management system in Android, in which we use contextual signals to build a classifier that predicts user privacy preferences under various scenarios. We performed a 37-person field study to evaluate this new permission model under normal device usage. From our exit interviews and collection of over 5 million data points from participants, we show that this new permission model reduces the error rate by 75% (i.e., fewer privacy violations), while preserving usability. We offer guidelines for how platforms can better support user privacy decision making.
Lung injury pathways: Adenosine receptor 2B signaling limits development of ischemic bronchiolitis obliterans organizing pneumonia

ABSTRACT Purpose/Aim of the Study: Adenosine signaling was studied in bronchiolitis obliterans organizing pneumonia (BOOP) resulting from unilateral lung ischemia. Materials and Methods: Ischemia was achieved by either left main pulmonary artery or complete hilar ligation. Sprague–Dawley (SD) rats, Dahl salt sensitive (SS) rats and SS mutant rat strains containing a mutation in the A2B adenosine receptor gene (Adora2b) were studied. Adenosine concentrations were measured in bronchoalveolar lavage (BAL) by HPLC. A2A (A2AAR) and A2B adenosine receptor (A2BAR) mRNA and protein were quantified. Results: Twenty-four hours after unilateral PA ligation, BAL adenosine concentrations from ischemic lungs were increased relative to contralateral lungs in SD rats. A2BAR mRNA and protein concentrations were increased after PA ligation while miR27a, a negatively regulating microRNA, was decreased in ischemic lungs. A2AAR mRNA and protein concentrations remained unchanged following ischemia. A2BAR protein was increased in PA ligated lungs of SS rats after 7 days, and 4 h after complete hilar ligation in SD rats. SS-Adora2b mutants showed a greater extent of BOOP relative to SS rats, and greater inflammatory changes. Conclusion: Increased A2BAR and adenosine following unilateral lung ischemia as well as more BOOP in A2BAR mutant rats implicate a protective role for A2BAR signaling in countering ischemic lung injury.
Cumulative risk effects in the bullying of children and young people with autism spectrum conditions

Students with autism are more likely to be bullied than their typically developing peers. However, several studies have shown that their likelihood of being bullied increases in the context of exposure to certain risk factors (e.g. behaviour difficulties and poor peer relationships). This study explores vulnerability to bullying from a cumulative risk perspective, where the number of risks rather than their nature is considered. A total of 722 teachers and 119 parents of young people with autism spectrum conditions participated in the study. Established risk factors were summed to form a cumulative risk score in teacher and parent models. There was evidence of a cumulative risk effect in both models, suggesting that as the number of risks increased, so did exposure to bullying. A quadratic effect was found in the teacher model, indicating that there was a disproportionate increase in the likelihood of being bullied in relation to the number of risk factors to which a young person was exposed. In light of these findings, it is proposed that more attention needs to be given to the number of risks to which children and young people with autism spectrum conditions are exposed when planning interventions and providing a suitable educational environment.
Morphological approach to hot tearing during continuous casting of steels

Abstract In the present work, plant samples were used to introduce a detailed understanding of the formation of hot tear segregations and open hot tears in the continuous casting process of steels. A more detailed sequence in four stages was proposed for the formation of hot tear segregations as well as open hot tears. Results revealed that hot tear segregations form in two spherical and elongated morphologies. The spherical precipitate hot tear segregations are caused by MnS particles, while the elongated precipitate hot tear segregations include more segregating elements. In addition, the outcomes showed that the spherical precipitate hot tear segregations, in comparison with the elongated hot tear segregations, are more associated with the open hot tear formation.
Mixed Critical Earliest Deadline First

Using the advances of the modern microelectronics technology, the safety-critical systems, such as avionics, can reduce their costs by integrating multiple tasks on one device. This makes such systems essentially mixed-critical, as this brings together different tasks whose safety assurance requirements may differ significantly. In the context of mixed-critical scheduling theory, we studied the dual criticality problem of scheduling a finite set of hard real-time jobs. In this work we propose an algorithm which is proved to dominate OCBP, a state-of-the art algorithm for this problem that is optimal over fixed job priority algorithms. We show through empirical studies that our algorithm can reduce the set of non-schedulable instances by a factor of two or, under certain assumptions, by a factor of four, when compared to OCBP.
Mental Health Treatment Seeking Patterns and Preferences of Appalachian Women With Depression

This qualitative study explored social-cultural factors that shape treatment seeking behaviors among depressed rural, low-income women in Appalachia—a region with high rates of depression and a shortage of mental health services. Recent research shows that increasingly rural women are receiving some form of treatment and identifying their symptoms as depression. Using purposive sampling, investigators recruited 28 depressed low-income women living in Appalachian Kentucky and conducted semistructured interviews on participants’ perceptions of depression and treatment seeking. Even in this sample of women with diverse treatment behaviors (half reported current treatment), participants expressed ambivalence about treatment and its potential to promote recovery. Participants stressed that poor treatment quality—not merely access—limited their engagement in treatment and at times reinforced their depression. While women acknowledged the stigma of depression, they indicated that their resistance to seek help for their depression was influenced by the expectation of women’s self-reliance in the rural setting and the gendered taboo against negative thinking. Ambivalence and stigma led women to try to cope independently, resulting in further isolation. This study’s findings reiterate the need for improved quality and increased availability of depression treatment in rural areas. In addition, culturally appropriate depression interventions must acknowledge rural cultural values of self-reliance and barriers to obtaining social support that lead many women to endure depression in isolation.
An Extended ADOP for Performance Evaluation of Single-Frequency Single-Epoch Positioning by BDS/GPS in Asia-Pacific Region

Single-Frequency Single-Epoch (SFSE) high-precision positioning has always been the hot spot of Global Navigation Satellite System (GNSS), and ambiguity dilution of precision (ADOP) is a well-known scalar measure for success rate of ambiguity resolution. Traditional ADOP expression is complicated, thus the SFSE extended ADOP (E-ADOP), with the newly defined Summation-Multiplication Ratio of Weight (SMRW) and two theorems for short baseline, was developed. This simplifies the ADOP expression; gives a clearer insight into the influences of SMRW and number of satellites on E-ADOP; and makes theoretical analysis of E-ADOP more convenient than that of ADOP, and through that the E-ADOP value can be predicted more accurately than through the ADOP expression for ADOP value. E-ADOP reveals that number of satellites and SMRW or high-elevation satellite are important for ADOP and, through E-ADOP, we studied which factor is dominant to control ADOP in different conditions and make ADOP different between BeiDou Navigation Satellite System (BDS), Global Positioning System (GPS), and BDS/GPS. Based on experimental results of SFSE positioning with different baselines, some conclusions are made: (1) ADOP decreases when new satellites are added mainly because the number of satellites becomes larger; (2) when the number of satellites is constant, ADOP is mainly affected by SMRW; (3) in contrast to systems where the satellites with low-elevation are the majority or where low- and high-elevation satellites are equally distributed, in systems where the high-elevation satellites are the majority, the SMRW mainly makes ADOP smaller, even if there are fewer satellites than in the two previous cases, and the difference in numbers of satellites can be expanded as the proportion of high-elevation satellites becomes larger; and (4) ADOP of BDS is smaller than ADOP of GPS mainly because of its SMRW.
Partial Sleep Deprivation Reduces the Efficacy of Orexin‐A to Stimulate Physical Activity and Energy Expenditure

Sufficient sleep is required for weight maintenance. Sleep deprivation due to noise exposure stimulates weight gain by increasing hyperphagia and reducing energy expenditure (EE). Yet the mechanistic basis underlying the weight gain response is unclear. Orexin‐A promotes arousal and negative energy balance, and orexin terminals project to the ventrolateral preoptic area (VLPO), which is involved in sleep‐to‐wake transitions. To determine whether sleep deprivation reduces orexin function in VLPO and to test the hypothesis that sleep deprivation would attenuate the orexin‐A‐stimulated increase in arousal, physical activity (PA), and EE.
In Vitro and In Vivo Evaluation of the Antifungal Activity of APX001A/APX001 against Candida auris

ABSTRACT Candida auris is an emerging multidrug-resistant yeast that has been responsible for invasive infections associated with high morbidity and mortality. C. auris strains often demonstrate high fluconazole and amphotericin B MIC values, and some strains are resistant to all three major antifungal classes. We evaluated the susceptibility of 16 C. auris clinical strains, isolated from a wide geographical area, to 10 antifungal agents, including APX001A, a novel agent that inhibits the fungal protein Gwt1 (glycosylphosphatidylinositol-anchored wall transfer protein 1). APX001A demonstrated significantly lower MIC50 and MIC90 values (0.004 and 0.031 μg/ml, respectively) than all other agents tested. The efficacy of the prodrug APX001 was evaluated in an immunocompromised murine model of disseminated C. auris infection. Significant efficacy (80 to 100% survival) was observed in all three APX001 treatment groups versus 50% survival for the anidulafungin treatment group. In addition, APX001 showed a significant log reduction in CFU counts in kidney, lung, and brain tissue (1.03 to 1.83) versus the vehicle control. Anidulafungin also showed a significant log reduction in CFU in the kidneys and lungs (1.5 and 1.62, respectively) but did not impact brain CFU. These data support further clinical evaluation of this new antifungal agent.
Characterization of damage induced by FIB etch and tungsten deposition in high aspect ratio vias

In this paper we studied three major issues that have challenged focused ion beam (FIB) circuit edit practices: via overetching, via composition which affects via resistance, and uniformity of via fill. These issues may become critical as minimal circuit dimensions reduce in the future. We investigated the amorphization induced by FIB gas assisted etch and ion beam induced metal deposition in high aspect ratio vias, using bright and dark field transmission electron microscopy images. A simple intuitive model is introduced to explain the differences in amorphization layer thicknesses between the steep FIB via sidewalls and the via floor. We analyze the dependence of FIB via purity on depth using EDS. Directions for future FIB applications are discussed in the paper along with a FIB via fill strategy.
The neutron star transient and millisecond pulsar in M28: from sub-luminous accretion to rotation-powered quiescence

The X-ray transient IGR J18245-2452 in the globular cluster M28 contains the first neutron star (NS) seen to switch between rotation-powered and accretion-powered pulsations. We analyse its 2013 March-April 25 d long outburst as observed by Swift, which had a peak bolometric luminosity of ∼6 per cent of the Eddington limit (LEdd), and give detailed properties of the thermonuclear burst observed on 2013 April 7. We also present a detailed analysis of new and archival Chandra data, which we use to study quiescent emission from IGR J18245-2452 between 2002 and 2013. Together, these observations cover almost five orders of magnitude in X-ray luminosity (LX, 0.5-10 keV). The Swift spectrum softens during the outburst decay (photon index Γ from 1.3 above LX/LEdd = 10−2 to ∼2.5 at LX/LEdd = 10−4), similar to other NS and black hole transients. At even lower luminosities, LX/LEdd = [10−4-10−6], deep Chandra observations reveal hard (Γ = 1-1.5), purely non-thermal and highly variable X-ray emission in quiescence. We therefore find evidence for a spectral transition at LX/LEdd ∼ 10−4, where the X-ray spectral softening observed during the outburst decline turns into hardening as the source goes to quiescence. Furthermore, we find a striking variability pattern in the 2008 Chandra light curves: rapid switches between a high-luminosity ‘active’ state (LX ≃ 3.9 × 1033 erg s−1) and a low-luminosity ‘passive’ state (LX ≃ 5.6 × 1032 erg s−1), with no detectable spectral change. We put our results in the context of low-luminosity accretion flows around compact objects and X-ray emission from millisecond radio pulsars. Finally, we discuss possible origins for the observed mode switches in quiescence, and explore a scenario where they are caused by fast transitions between the magnetospheric accretion and pulsar wind shock emission regimes.
Peripheral nerves are pathologically small in cerebellar ataxia neuropathy vestibular areflexia syndrome: a controlled ultrasound study

Sensory neuronopathy is a cardinal feature of cerebellar ataxia neuropathy vestibular areflexia syndrome (CANVAS). Having observed that two patients with CANVAS had small median and ulnar nerves on ultrasound, we set out to examine this finding systematically in a cohort of patients with CANVAS, and compare them with both healthy controls and a cohort of patients with axonal neuropathy. We have previously reported preliminary findings in seven of these patients with CANVAS and seven healthy controls.
Patient‐Related Risk Factors for Periprosthetic Ankle Joint Infection: An Analysis of 6977 Total Ankle Arthroplasties

&NA; Periprosthetic joint infection (PJI) after total ankle arthroplasty (TAA) is a devastating complication that often results in explantation to resolve the infection. The purpose of the present investigation was to determine the patient‐related risk factors for PJI after TAA. A national insurance database was queried for patients undergoing TAA using the Current Procedural Terminology and International Classification of Diseases, ninth revision, procedure codes from 2005 to 2012. Patients undergoing TAA with concomitant fusion procedures or more complex forefoot procedures were excluded. PJI within 6 months was then assessed using the International Classification of Diseases, ninth revision, codes for diagnosis or treatment of postoperative PJI. Multivariate binomial logistic regression analysis was performed to evaluate the patient‐related risk factors for PJI. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were calculated for each risk factor, with p < . 05 considered statistically significant. A total of 6977 patients were included in the present study. Of these 6977 patients, 294 (4%) had a diagnosis of, or had undergone a procedure for, PJI. The independent risk factors for PJI included age <65 years (OR 1.44; p = .036), body mass index <19 kg/m2 (OR 3.35; p = .013), body mass index >30 kg/m2 (OR 1.49; p = .034), tobacco use (OR 1.59; p = .002), diabetes mellitus (OR 1.36; p = .017), inflammatory arthritis (OR 2.38; p < .0001), peripheral vascular disease (OR 1.64; p < .0001), chronic lung disease (OR 1.37; p = .022), and hypothyroidism (OR 1.32; p = .022). The independent patient‐related risk factors identified in the present study should help guide physicians and patients considering elective TAA and develop risk stratification algorithms that could decrease the risk of deep, postoperative infection. &NA; Level of Clinical Evidence: 3
Phylogenomic Based Comparative Studies on Indian and American Commensal Staphylococcus epidermidis Isolates

Staphylococcus epidermidis is a prominent commensal member of human skin microbiome and an emerging nosocomial pathogen, making it a good model organism to provide genomic insights, correlating its transition between commensalism and pathogenicity. While there are numerous studies to understand differences in commensal and pathogenic isolates, systematic efforts to understand variation and evolutionary pattern in multiple strains isolated from healthy individuals are lacking. In the present study, using whole genome sequencing and analysis, we report presence of diverse lineages of S. epidermidis isolates in healthy individuals from two geographically diverse locations of India and North America. Further, there is distinct pattern in the distribution of candidate gene(s) for pathogenicity and commensalism. The pattern is not only reflected in lineages but is also based on geographic origin of the isolates. This is evident by the fact that North American isolates under this study are more genomically dynamic and harbor pathogenicity markers in higher frequency. On the other hand, isolates of Indian origin are less genomically dynamic, harbor less pathogenicity marker genes and possess two unique antimicrobial peptide gene clusters. This study provides a basis to understand the nature of selection pressure in a key human skin commensal bacterium with implications in its management as an opportunistic pathogen.
Light-Dependent OCT Structure Changes in Photoreceptor Degenerative rd 10 Mouse Retina

Purpose Using optical coherence tomography (OCT) to analyze the effects of light/dark adaptation in a mouse model of inherited photoreceptor degeneration (rd10), and to study dynamics of subretinal fluid during the progress of retinal degeneration. Methods rd10 and wild-type (WT) C57BL/6J mice were reared in cyclic light or darkness and imaged with Bioptigen UHR-OCT or Spectralis HRA+OCT after adaptation to either light or darkness. Results OCT images from rd10 mice were analyzed at three progressive stages of degeneration. After light-adaptation, stage I (postnatal age [P]26–29) eyes demonstrated no apparent subretinal fluid. At stage II (P32–38), subretinal fluid was present and restricted to parapapillary area, while at stage III (P44–45) extensive subretinal fluid was present across many retinal areas. Following overnight dark-adaptation, WT eyes showed a large reduction in outer retinal thickness (4.6 ± 1.4 μm, n = 16), whereas this change was significantly smaller in stage I rd10 eyes (1.5 ± 0.5 μm, n = 14). In stage II rd10 eyes, dark-adaptation significantly reduced the extent of subretinal fluid, with the amount of reduction correlating with the amount of fluid pre-existing in the light-adapted state. However, dark-adaptation did not significantly alter the amount of subretinal fluid observed in stage III rd10 mice. In addition, dark-rearing of rd10 mice from P6 to P30 slowed retinal degeneration. Conclusions Visual experience in the form of light/dark adaptation exerts a significant effect on outer retinal structure in the context of photoreceptor degeneration. This effect may arise from light-dependent alterations in fluid transport across the RPE monolayer, and promote photoreceptor survival as induced by dark-rearing.
Optimal Financial Contracts for a Start-Up with Unlimited Operating Discretion

Abstract The model presented here shows that extreme uncertainty between an entrepreneur and potential investors can lead to the exclusive use of equity and riskless debt for small business financing. The paper derives these results without any restrictions on the available contract space, the distribution function governing a project's payoff, or the risk aversion of most potential entrepreneurs. In addition, the model produces predictions regarding the “under-pricing”; of securities to outside financiers, the order in which firms will issue securities, and the relationship between the types of securities a firm will issue and its available collateral.
An Approximate Optimal Control Approach for Robust Stabilization of a Class of Discrete-Time Nonlinear Systems With Uncertainties

In this correspondence paper, the robust stabilization of a class of discrete-time nonlinear systems with uncertainties is investigated by using an approximate optimal control approach. The robust control problem is transformed into an optimal control problem under some proper restrictions on the bound of the uncertainties. For the purpose of dealing with the transformed optimal control, the discrete-time generalized Hamilton-Jacobi-Bellman equation is introduced and then solved using the successive approximation method with neural network implementation. In addition, a numerical simulation is included to illustrate the effectiveness of the robust control strategy.