Miracle-dz/UniFAR-FTUs huggingface dataset:
Inversion channel MOSFETs in 3C-SiC on silicon

Abstract : As a substrate material, single crystal SiC wafers are commercially available in diameters up to 75 mm, whereas silicon wafers a? e available in diameters of 200-300 mm. SiC wafers remain quite expensive compared to silicon, and contain%troublesome densities of micropipes that limit the yield of large devices. In the past, several groups have attempted to circumvent these problems by fabricating devices in 3C-SiC films grown epitaxially on silicon substrates, with limited success. However, in this paper we report new results demonstrating high quality inversion channel MOSFETs in 3C-SiC films on silicon. The inversion channel mobility of SiC MOSFETs has been limited to < 50 cm2JVs in the 4H polytype and < 100 cm2fVs in the 6H polytype by a high density of interface states in the upper half of the bandgap. Because of its narrower bandgap, the 3C polytype of SiC is expected to have lower interface state density, leading to higher channel mobilities. We fabricated lateral n-channel MOSFETs in 6 pin p-type epilayers of 3C-SiC grown on 20 off-axis Si(001) substrates. The epilayers were subsequently polished to improve surface smoothness, leaving a 3 %im layer. Sacrificial oxidation was then performed to remove damage caused by polishing. Source and drains were formed by implanting phosphorus and activating at 1250 0C for 30 minutes in argon. The gate oxide was formed by wet oxidation at 1150 0C for 30 minutes, followed by re-oxidation in wet O2 at 950 0C for two hours. A polysilicon gate was deposited by LPCVD and doped by spin-on dopant. Ohmic contacts are unannealed nickel. The resulting MOSFETs show excellent transistor behavior, with good current saturation, a threshold voltage of 1.6 V, and a peak channel mobility of 170 cm2/Vs.
Unraveling Cellular Phenotypes of Novel TorsinA/TOR1A Mutations

A three‐nucleotide (GAG) deletion (ΔE) in TorsinA (TOR1A) has been identified as the most common cause of dominantly inherited early‐onset torsion dystonia (DYT1). TOR1A encodes a chaperone‐like AAA+‐protein localized in the endoplasmic reticulum. Currently, only three additional, likely mutations have been reported in single dystonia patients. Here, we report two new, putative TOR1A mutations (p.A14_P15del and p.E121K) that we examined functionally in comparison with wild‐type (WT) protein and two known mutations (ΔE and p.R288Q). While inclusion formation is a characteristic feature for ΔE TOR1A, elevated levels of aggregates for other mutations were not observed when compared with WT TOR1A. WT and mutant TOR1A showed preferred degradation through the autophagy‐lysosome pathway, which is most pronounced for p.A14_P15del, p.R288Q, and ΔE TOR1A. Notably, blocking of the autophagy pathway with bafilomycin resulted in a significant increase in inclusion formation in p.E121K TOR1A. In addition, all variants had an influence on protein stability. Although the p.A14_P15del mutation affects the proposed oligomerization domain of TOR1A, this mutation did not disturb the ability to dimerize. Our findings demonstrate functional changes for all four mutations on different levels. Thus, both diagnostic and research genetic screening of dystonia patients should not be limited to testing for the ∆E mutation.
A Pitch Tracking Corpus with Evaluation on Multipitch Tracking Scenario

In this paper, we introduce a novel pitch tracking database (PTDB) including ground truth signals obtained from a laryngograph. The database, referenced as PTDB-TUG, consists of 2342 phonetically rich sentences taken from the TIMIT corpus. Each sentence was at least recorded once by a male and a female native speaker. In total, the database contains 4720 recordings from 10 male and 10 female speakers. Furthermore, we evaluated two multipitch tracking systems on a subset of speakers to provide a benchmark for further research activities. The database can be downloaded at http://www.spsc. tugraz.at/tools.
Characterization of mechanisms involved in transrepression of NF-kappa B by activated glucocorticoid receptors

Glucocorticoids are potent immunosuppressants which work in part by inhibiting cytokine gene transcription. We show here that NF-kappa B, an important regulator of numerous cytokine genes, is functionally inhibited by the synthetic glucocorticoid dexamethasone (DEX). In transfection experiments, DEX treatment in the presence of cotransfected glucocorticoid receptor (GR) inhibits NF-kappa B p65-mediated gene expression and p65 inhibits GR activation of a glucocorticoid response element. Evidence is presented for a direct interaction between GR and the NF-kappa B subunits p65 and p50. In addition, we demonstrate that the ability of p65, p50, and c-rel subunits to bind DNA is inhibited by DEX and GR. In HeLa cells, DEX activation of endogenous GR is sufficient to block tumor necrosis factor alpha or interleukin 1 activation of NF-kappa B at the levels of both DNA binding and transcriptional activation. DEX treatment of HeLa cells also results in a significant loss of nuclear p65 and a slight increase in cytoplasmic p65. These data reveal a second mechanism by which NF-kappa B activity may be regulated by DEX. We also report that RU486 treatment of wild-type GR and DEX treatment of a transactivation mutant of GR each can significantly inhibit p65 activity. In addition, we found that the zinc finger domain of GR is necessary for the inhibition of p65. This domain is also required for GR repression of AP-1. Surprisingly, while both AP-1 and NF-kappa B can be inhibited by activated GR, synergistic NF-kappa B/AP-1 activity is largely unaffected. These data suggest that NF-kappa B, AP-1, and GR interact in a complex regulatory network to modulate gene expression and that cross-coupling of NF-kappa B and GR plays an important role in glucocorticoid-mediated repression of cytokine transcription.
Locality-sensitive Hashing without False Negatives

We consider a new construction of locality-sensitive hash functions for Hamming space that is covering in the sense that is it guaranteed to produce a collision for every pair of vectors within a given radius r. The construction is efficient in the sense that the expected number of hash collisions between vectors at distance cr, for a given c > 1, comes close to that of the best possible data independent LSH without the covering guarantee, namely, the seminal LSH construction of Indyk and Motwani (FOCS '98). The efficiency of the new construction essentially matches their bound if cr = log(n)/k, where n is the number of points in the data set and k ∈ N, and differs from it by at most a factor ln(4) in the exponent for general values of cr. As a consequence, LSH-based similarity search in Hamming space can avoid the problem of false negatives at little or no cost in efficiency.
Cleavage of aggrecan at the Asn341-Phe342 site coincides with the initiation of collagen damage in murine antigen-induced arthritis: a pivotal role for stromelysin 1 in matrix metalloproteinase activity.

OBJECTIVE The destruction of articular cartilage during arthritis is due to proteolytic cleavage of the extracellular matrix components. This study investigates the kinetic involvement of metalloproteinases (MMPs) in the degradation of the 2 major cartilage components, aggrecan and type II collagen, during murine antigen-induced arthritis (AIA). In addition, the role of stromelysin 1 (SLN-1) induction of MMP-induced neoepitopes was studied. METHODS VDIPEN neoepitopes in aggrecan and collagenase-induced COL2-3/4C neoepitopes in type II collagen were identified by immunolocalization. Stromelysin 1-deficient knockout (SLN1-KO) mice were used to study SLN-1 involvement. RESULTS In AIA, the VDIPEN epitopes in aggrecan appeared after initial proteoglycan (PG) depletion. The collagenase-induced type II collagen neoepitopes colocalized with VDIPEN epitopes. Remarkably, cartilage from arthritic SLN1-KO mice showed neither the induction of VDIPEN nor collagen cleavage-site neoepitopes during AIA, suggesting that stromelysin is a pivotal mediator in this process. PG depletion, as measured by the loss of Safranin O staining, was similar in SLN1-KO mice and wild-type strains. Furthermore, in vitro induction of VDIPEN epitopes in aggrecan and COL2-3/4C epitopes in type II collagen, on exposure of cartilage to interleukin-1, could not be accomplished in SLN1-KO mice, whereas intense staining was achieved for both epitopes in cartilage of wild-type strains. CONCLUSION This study emphasizes that SLN-1 is essential in the induction of MMP-specific aggrecan and collagen cleavage sites during AIA. It suggests that SLN-1 is not a dominant enzyme in PG breakdown, but that it activates procollagenases and is crucial in the initiation of collagen damage.
Comparing the accuracy of density forecasts from competing models

A rapidly growing literature emphasizes the importance of evaluating the forecast accuracy of empirical models on the basis of density (as opposed to point) forecasting performance. We propose a test statistic for the null hypothesis that two competing models have equal density forecast accuracy. Monte Carlo simulations suggest that the test, which has a known limiting distribution, displays satisfactory size and power properties. The use of the test is illustrated with an application to exchange rate forecasting. Copyright © 2004 John Wiley & Sons, Ltd.
Essential features of the P-glycoprotein pharmacophore as defined by a series of reserpine analogs that modulate multidrug resistance.

We have shown previously that reserpine is an effective "modulator" of P-glycoprotein-associated multidrug resistance (MDR). In addition to enhancing drug cytotoxicity in our multidrug-resistant human leukemia cell line, CEM/VLB100, reserpine strongly competes with a photoactivatible analog of vinblastine, N-(p-azido-3-[125I]iodosalicyl)-N'-(beta-aminoethyl)vindesine, for binding to P-glycoprotein. We also demonstrated previously that there are three substructural domains present in many compounds that modulate P-glycoprotein-associated MDR: a basic nitrogen atom and two planar aromatic rings. In the present study, we wished to test more rigorously the hypothesis that not only are these domains necessary for modulators of MDR but also they must exist in an appropriate conformation. Reserpine is a modulator of MDR in which these domains are present in a well-defined conformation. Accordingly, we prepared eight compounds that vary the spatial orientation of these domains, using either naturally occurring reserpine or yohimbine as chemical templates. When tested for their ability to enhance the cytotoxic activity of natural product antitumor drugs in CEM/VLB100 cells, five compounds that retained the pendant benzoyl function in an appropriate spatial orientation all modulated MDR. By contrast, compounds lacking this moiety failed to do so. These active modulators competed strongly with the 125I-labeled vinblastine analog for binding to P-glycoprotein in plasma membrane vesicles prepared from these cells. Conformational analysis using molecular mechanics revealed the structural similarities of the active modulators. Our results support the hypothesis that the relative disposition of aromatic rings and basic nitrogen atom is important for modulators of P-glycoprotein-associated MDR, and they suggest a ligand-receptor relationship for these agents. These results also provide direction for the definition of an MDR "pharmacophore. "
ITO/MoOx/a-Si:H(i) Hole-Selective Contacts for Silicon Heterojunction Solar Cells: Degradation Mechanisms and Cell Integration

Molybdenum oxide is an efficient hole collector for silicon solar cells. However, its optoelectronic properties deteriorate during cell manufacturing. To assess this issue, the optoelectronic properties and microstructure of molybdenum oxide-based hole contacts are evaluated at different steps of the manufacturing process. Molybdenum oxide becomes more absorbing as it reduces when placed in contact with hydrogenated amorphous silicon, triggering the formation of a 2-nm thick SiOx layer, and when annealed after exposure to the plasma used to sputter the transparent conductive oxide. These changes in the contact properties result in a barrier that impedes hole transport when measuring I–V characteristics at room temperature. Nonetheless, cells still reach an efficiency of up to 20.7% when using a front metal electrode screen-printed at 210 °C (21.7% for reference cells). Above 60 °C, both molybdenum oxide-based and reference cells exhibit the same efficiency as this barrier to hole transport vanishes.
Lipid oxidation and color changes of goose meat stored under vacuum and modified atmosphere conditions

&NA; The objective of the work was to investigate the color and lipid oxidation changes of goose breast meat packaged in vacuum and modified atmosphere (MA) conditions consisting of 80% O2, 20% CO2, and stored in refrigerated conditions at 4°C. Color stability was monitored by determining total heme pigments concentration; relative concentration of myoglobin, oxymyoglobin, and metmyoglobin; parameters of color L*, a*, b*, and sensory evaluation of the surface color. Lipid stability was measured by determining thiobarbituric acid reactive substances (TBARS). The samples were examined in 24 h after slaughter (unpacked muscles) and on d 4, 7, 9, 11 of storage (muscles packed in vacuum and in MA). Through the time of storage, samples packed in MA had higher TBARS values in comparison to the meat packed in vacuum. For samples packed in two types of atmospheres, the total pigments concentration decreased gradually within 11 d of storage. It was observed that relative metmyoglobin concentration increased whereas relative oxymyoglobin concentration decreased in total heme pigments in the MA stored muscle. The relative concentration of all three myoglobin forms sample packed in vacuum remained unchanged. The color parameters (L*, a*, b*) did not change for 11 d of storage for the vacuum packed meat. The value of the color parameter a* decreased and the value of the color parameters L* and b* increased in the samples packaged in MA. The data prove that if you store goose meat in MA (consisting of 80% O2, 20% CO2) or vacuum, the unchanged surface color is preserved for 9 and 11 day, respectively. Vacuum appears to be a better method as regards the maintaining of lipid stability in goose meat.
Building student belonging and engagement: insights into higher education students’ experiences of participating and learning together

ABSTRACT Student belonging and engagement has received increased attention in the context of an expanding and more diverse higher education student population. Student retention is regarded as a priority with many universities augmenting their retention strategies to instil a sense of belonging. This article provides insights into first year Business Management students’ experiences of starting their degrees and retention interventions at a university in the South of England. It is based on findings from an ongoing study that applied Wenger's social theory of learning and adopted an appreciative inquiry approach to focus group interviewing to investigate students’ perceptions. Students developed a sense of belonging, constructed learner identities, made sense of their learning and gained confidence, but also experienced instances of tension and frustration that raise questions about the extent to which sociality practices within evolving communities of practice can address diverse engagement and identity development needs and mitigate disengagement.
Pharmacotherapy of School Refusal

This paper reviews the role and indications for pharmacotherapy of children with school refusal. The psychopharmacological treatment of school refusal is based mainly on evidence of the effectiveness of certain drugs in the treatment of adult disorders. There is some evidence that tricyclic antidepressants and benzobiazepines may be specifically useful in the treatment of school refusal, but further research is warranted. Potentially serious side effects mean that drugs are best confined to cases where psychological treatments have not been effective or where drugs are used briefly as an adjunct to a broader psychological treatment plan. Drugs may also have a role in the specific treatment of comorbid conditions associated with school refusal. Any use of drugs should involve regular reviews to monitor response, compliance, and side effects.
ClubSub-P: Cluster-Based Subcellular Localization Prediction for Gram-Negative Bacteria and Archaea

The subcellular localization (SCL) of proteins provides important clues to their function in a cell. In our efforts to predict useful vaccine targets against Gram-negative bacteria, we noticed that misannotated start codons frequently lead to wrongly assigned SCLs. This and other problems in SCL prediction, such as the relatively high false-positive and false-negative rates of some tools, can be avoided by applying multiple prediction tools to groups of homologous proteins. Here we present ClubSub-P, an online database that combines existing SCL prediction tools into a consensus pipeline from more than 600 proteomes of fully sequenced microorganisms. On top of the consensus prediction at the level of single sequences, the tool uses clusters of homologous proteins from Gram-negative bacteria and from Archaea to eliminate false-positive and false-negative predictions. ClubSub-P can assign the SCL of proteins from Gram-negative bacteria and Archaea with high precision. The database is searchable, and can easily be expanded using either new bacterial genomes or new prediction tools as they become available. This will further improve the performance of the SCL prediction, as well as the detection of misannotated start codons and other annotation errors. ClubSub-P is available online at http://toolkit.tuebingen. mpg.de/clubsubp/
Effects of Cover Stories on Problem Solving in a Statistics Course

Does having more knowledge or interest in the topics used in example problems facilitate or hinder learning in statistics? Undergraduates enrolled in Introductory Psychology received a lesson on central tendency. Following the lesson, half of the students completed a worksheet with a baseball cover story while the other half received a weather cover story. Learning was assessed using a quiz that contained two kinds of items: computation and explanation. Measures of baseball knowledge and interest in baseball were collected. The results indicated that overall the students performed better on computation items than explanation items. The weather example led to better performance on the explanation items than the baseball example. No differences were seen in performance on the quiz as a function of gender, prior knowledge, or interest. If anything, the results indicated that interest in baseball seemed to hinder learning in the baseball condition. Possible reasons for differences in performance due to the cover story are discussed. Corresponding Author: Travis Rex Ricks, Bemidji State University. Email: travisr.ricks@gmail.com
Genetic Separation of Sae2 Nuclease Activity from Mre11 Nuclease Functions in Budding Yeast

ABSTRACT Sae2 promotes the repair of DNA double-strand breaks in Saccharomyces cerevisiae. The role of Sae2 is linked to the Mre11/Rad50/Xrs2 (MRX) complex, which is important for the processing of DNA ends into single-stranded substrates for homologous recombination. Sae2 has intrinsic endonuclease activity, but the role of this activity has not been assessed independently from its functions in promoting Mre11 nuclease activity. Here we identify and characterize separation-of-function mutants that lack intrinsic nuclease activity or the ability to promote Mre11 endonucleolytic activity. We find that the ability of Sae2 to promote MRX nuclease functions is important for DNA damage survival, particularly in the absence of Dna2 nuclease activity. In contrast, Sae2 nuclease activity is essential for DNA repair when the Mre11 nuclease is compromised. Resection of DNA breaks is impaired when either Sae2 activity is blocked, suggesting roles for both Mre11 and Sae2 nuclease activities in promoting the processing of DNA ends in vivo. Finally, both activities of Sae2 are important for sporulation, indicating that the processing of meiotic breaks requires both Mre11 and Sae2 nuclease activities.
Teaching of Research Methods in Undergraduate Psychology Courses: A Survey of Provision in HE Institutions and Colleges in the UK

It is widely acknowledged that systematic observation is an important research method, and hence should be a core element in psychology curricula. UK higher education institutions (HEIs) were surveyed about their psychological research methods teaching, and in particular observational research methods. The survey indicated considerable variation across responding HEIs in equipment availability, class size, and preparation and contact time, though there was a degree of consensus in the use of SPSS, identified learning outcomes and assessment strategies. Considerable interest was expressed for the provision of self-contained, relatively short, sets of materials teaching key features of observational research methods, with a preference for the inclusion of developmental psychology video materials. The parallels with the concept of ‘learning object’ are discussed.