Miracle-dz/UniFAR-FTUs huggingface dataset:
The Relationship Between Emotion Dysregulation and Impulsive Aggression in Veterans With Posttraumatic Stress Disorder Symptoms

While Veterans in general are no more dangerous than the civilian population, Veterans with posttraumatic stress disorder (PTSD) have stronger associations with anger and hostility and certain forms of aggression, such as intimate partner violence, than civilians with PTSD. This is alarming because up to 21% of Veterans seeking Veterans Affairs (VA) health care are diagnosed with PTSD. Emotion regulation difficulties (emotion dysregulation) are also related to increased PTSD symptom severity and may play a role in aggressive behavior. Because the predominant form of aggression in PTSD appears to be the impulsive subtype, the authors sought to clarify the relationship between PTSD, emotion dysregulation, and impulsive aggression. We examined how emotion dysregulation influenced impulsive aggression in a Veteran sample (N = 479) seeking treatment for trauma sequelae. All Veterans completed measures that assessed demographic information, emotion dysregulation, aggression frequency and subtype, and PTSD symptoms. Men generally reported more aggression than women. The emotion dysregulation, aggression, and PTSD measures were significantly correlated. Two cross-sectional mediation models showed emotion dysregulation fully accounted for the relationship between PTSD and impulsive aggression (indirect path for men: b = .07, SE = .026, bias-correct and accelerated confidence interval [BCa CI] = [0.02, 0.13]; indirect path for women: b = .08, SE = .022, BCa CI = [0.05, 0.13]). PTSD can increase negative emotions yet does not always lead to aggressive behaviors. The ability to regulate emotions may be pivotal to inhibiting aggression in those with PTSD. PTSD interventions may benefit from augmentation with emotion regulation skills training.
Initial and delayed stress phase imaging in a single-injection double-acquisition SPECT. The potential value of early 99mTc-MIBI redistribution in assessment of myocardial perfusion reversibility in patients with coronary artery disease.

UNLABELLED Some studies reported that 99mTc-MIBI may redistribute in ischaemic myocardium and this phenomenon may have potential role for better assessment of viability by delayed 99mTc-MIBI imaging. Some studies also suggested that infusion of low dose dobutamine during delayed imaging may enhance the value of 99mTc-MIBI imaging for evaluation of viability. The aim of this study is to determine whether the observed changes of perfusion defects on delayed images are caused by early radiotracer redistribution or as a result of reversal partial volume effect secondary to inotropic stimulation. PATIENTS, METHODS 89 patients with angiographically proven coronary artery disease (CAD) were enrolled in this randomized clinical trial study. In all cases, gated-SPECT images were obtained 60 minutes after stress with dipyridamole injection. Subsequently the patients were randomly allocated in two groups and the second imaging was performed at 120th minute during low dose dobutamine (dobutamine group; 45 cases) or placebo infusion (placebo group; 44 cases). Difference between summed stress score of the first (SSS1) and second (SSS2) stress images (DeltaSSS) was considered as a marker of reversibility in single-injection double-acquisition (SIDA) protocol. Also summed difference score (SDS) was recorded as a marker of reversibility in standard stress/rest, double-injection double-acquisition (DIDA) protocol. DeltaSSS of the two studied groups were compared. Also the correlation and agreement between DeltaSSS and SDS were analyzed. RESULTS A significant difference was found between SSS1 (median 15, range 0-48) and SSS2 (median 11, range 0-42) in total patients (p < 0.0001). A significant correlation was noted between DeltaSSS and SDS in dobutamine group (r = 0.58, p = 0.002) as well as in placebo group (r = 0.57, p < 0.0001). Considering DIDA protocol as a standard reference method, the influence of dobutamine infusion was not shown to be significantly different from the placebo effect on the magnitude of fixed or reversible perfusion defects in SIDA protocol. CONCLUSION The changes in the magnitude of the perfusion defects may occur in the first hours of 99mTc-MIBI injection in the stress phase imaging. These changes correlate well and are in agreement with perfusion improvement on the rest images. This phenomenon may be independent of improvement in myocardial function, in more delayed imaging or following inotropic augmentation, and thus is likely due to 99mTc-MIBI redistribution. This may open new technical and clinical aspects and potentials for 99mTc-MIBI imaging.
The Role of Genetic Variants in the Association between Dietary Acrylamide and Advanced Prostate Cancer in the Netherlands Cohort Study on Diet and Cancer

ABSTRACT To investigate the association between dietary acrylamide and advanced prostate cancer, we examined acrylamide-gene interactions for advanced prostate cancer risk by using data from the Netherlands Cohort Study. Participants (n = 58,279 men) completed a baseline food frequency questionnaire (FFQ), from which daily acrylamide intake was calculated. At baseline, 2,411 men were randomly selected from the full cohort for case-cohort analysis. Fifty eight selected single nucleotide polymorphisms (SNPs) and two gene deletions in genes in acrylamide metabolism, DNA repair, sex steroid systems, and oxidative stress were analyzed. After 20.3 years of follow-up, 1,608 male subcohort members and 948 advanced prostate cancer cases were available for Cox analysis. Three SNPs showed a main association with advanced prostate cancer risk after multiple testing correction: catalase (CAT) rs511895, prostaglandin-endoperoxide synthase 2 (PTGS2) rs5275, and xeroderma pigmentosum group C (XPC) rs2228001. With respect to acrylamide-gene interactions, only rs1800566 in NAD(P)H quinone dehydrogenase 1 (NQO1) and rs2301241 in thioredoxin (TXN) showed a nominally statistically significant multiplicative interaction with acrylamide intake for advanced prostate cancer risk. After multiple testing corrections, none were statistically significant. In conclusion, no clear evidence was found for interaction between acrylamide intake and selected genetic variants for advanced prostate cancer risk.
Energy and Protein in Critically Ill Patients with AKI: A Prospective, Multicenter Observational Study Using Indirect Calorimetry and Protein Catabolic Rate

The optimal nutritional support in Acute Kidney Injury (AKI) still remains an open issue. The present study was aimed at evaluating the validity of conventional predictive formulas for the calculation of both energy expenditure and protein needs in critically ill patients with AKI. A prospective, multicenter, observational study was conducted on adult patients hospitalized with AKI in three different intensive care units (ICU). Nutrient needs were estimated by different methods: the Guidelines of the European Society of Parenteral and Enteral Nutrition (ESPEN) for both calories and proteins, the Harris-Benedict equation, the Penn-State and Faisy-Fagon equations for energy. Actual energy and protein needs were repeatedly measured by indirect calorimetry (IC) and protein catabolic rate (PCR) until oral nutrition start, hospital discharge or renal function recovery. Forty-two patients with AKI were enrolled, with 130 IC and 123 PCR measurements obtained over 654 days of artificial nutrition. No predictive formula was precise enough, and Bland-Altman plots wide limits of agreement for all equations highlight the potential to under- or overfeed individual patients. Conventional predictive formulas may frequently lead to incorrect energy and protein need estimation. In critically ill patients with AKI an increased risk for under- or overfeeding is likely when nutrient needs are estimated instead of measured.
The effect of role assignment and personality subtypes in simulation on critical thinking development, situation awareness, and perceived self-efficacy of nursing baccalaureate students.

descriptions (Whitaker & Klein, 1988) to detailed descriptions (Harwood, Barnett, & Wickens, 1988). An important aspect to the temporal dimension of situation awareness is understanding that situation awareness assessments are made by maintaining an active model of the world that is continuously updated based on current events (Harwood, et al., 1988). This description of how situation awareness changes over time is considered when designing how situation awareness will be measured in this study. There is a belief that situation awareness improves after simulation use, but there lacks a nursing-relevant situation awareness measurement tool (Lavoie et al., 2015). There is a need for more research dedicated to developing tools to measure and develop situation awareness (Lavoie, et al., 2015; McKenna, et al., 2014; O’Meara, et al., 2014). Lavoie et al. has developed an instrument to use for situation awareness measurement in the healthcare domain, but calls for future research to determine the instrument’s effectiveness. Alternative methods to develop situation awareness, such as eye tracking and video debriefing usage, are concepts still being matured (O’Meara et al., 2014). In summary, there are multiple plausible avenues to assess and measure situation awareness (especially in the aviation domain), but few have been applied to healthcare training.
Evaluation of the Role of Radiotherapy in Early Breast Cancer

* Abstract: Purpose: Retrospective study for evaluation of the role of radiotherapy in early breast cancer patients T1- 2 M0 with (0-3 positive axillary LNs) as regard disease free survival (DFS) and over all survival (OS). Patients and methods: Between January 1999 to December 2004, ninety patients pathologically confirmed early breast cancer were classified into two groups, 50 patients in the first group were treated with Modified Radical Mastectomy (MRM) + adjuvant radiation therapy + systemic therapy (Chemotherapy and/or hormonal therapy) and 40 patients in the second group were treated with MRM + adjuvant systemic therapy. All patients entered in this study were monitored for treatment related events, toxicity, loco-regional and distant failure, time to death and survival. The (OS) rates and(DFS) rates depicted on Kaplan Meier plots. Results:Patients in the first group who received radiation therapy developed less loco-regional recurrence rate (8% vs 22.5%) than did those receiving no radiation therapy in the second group with no significances statistical, p=>0.05. According to the time gap since surgery to radiation therapy, twenty six percent of patients who received radiation therapy in period more than 3 months from the surgical interference had developed loco-regional failure vs no patients in population who received radiation therapy in period less than 3 months since surgical interference with statistical significant difference (P<0.005). Within 50 patients in the first group, skin desquamation was the most common acute complication of radiation therapy (20%) and hyperpigmentation was the most common late effect of radiation therapy (30%). There was statistical significant difference for the 5- year loco-regional recurrence free survival rates according to the treatment modalities in the first group versus those in the second group( 88.24% vs 73.16 respectively ,P=0.0308). There was insignificant improvement in the 5-year (OS) rates and the 5-year (DFS) rates according to treatment modalities in the first group versus the second group, (70.62% vs 61.00%, p=0.2145) for (OS) rates and (51.54% vs 44.38%, p=0.111) for (DFS) rates respectively. Nodal and hormonal status was the only two prognostic factors that significantly influence (OS) and (DFS) rates. Bone was the most common site of distant failure in this retrospective study. Conclusions: Despite the improvement in loco-regional recurrence rates, loco-regional recurrence free survival rates, five-year (OS) and 5-year (DFS) rates for patients in the first group who received radiation therapy, still the value of routine use of radiation therapy in early breast cancer is unclear. (Laila A. Korashy; Mahmoud M. Elgantiry and Fatma Zakaria. Evaluation of the Role of Radiotherapy in Early Breast Cancer. Life Science Journal. 2011;8(1):145-153). (ISSN:1097-8135). http://www.lifesciencesite. com.
Lateral Canthal Position Following Lateral Orbitotomy and the Influence of Ocular Proptosis

Purpose: Anecdotal evidence suggests that detachment of the lateral canthal tendon during lateral orbitotomy results in shortening of the horizontal palpebral aperture (HPA) and rounding of the lateral canthal angle (LCA). This study investigated the change in HPA and LCA following lateral orbitotomy and the effect of proptosis on the HPA. Methods: Retrospective, single surgeon, review of all cases undergoing lateral orbitotomy, comprising of a canthotomy and cantholysis and reconstruction of the lateral canthus using a single suture. The HPA and lateral canthal height (LCH) were measured on pre- and postoperative photographs using ImageJ software. Changes in the LCA and degree of proptosis were also investigated. Exclusion criteria included previous eyelid surgery, acute trauma, and less than 6 months’ follow up. Results: There were 41 cases of lateral orbitotomy in 27 patients, 67% female, average age 51 years. Twenty patients had thyroid eye disease of which 14 underwent bilateral surgery; the other 7 patients had a variety of orbital pathologies. Thirteen patients underwent unilateral orbitotomy with the contralateral eye serving as a control. Average follow up was 23 months. Overall, the HPA and proptosis were reduced by 0.6 mm (p = 0.143) and 3.4 mm (p < 0.001), respectively. A 0.2-mm reduction in HPA was observed for every 1-mm reduction in proptosis. A difference in post-orbitotomy HPA was observed between cases and their matched controls (p = 0.016). No rounding of the LCA or significant change in LCH was observed following lateral orbitotomy. Conclusions: The described technique of lateral orbitotomy and simple reconstruction do not appear to cause lateral canthal drift or rounding. There was no significant change in HPA or LCH. The degree of change of proptosis does appear to influence the change of HPA.
Dynamic Data Exchange in Distributed RDF Stores

When RDF datasets become too large to be managed by centralised systems, they are often distributed in a cluster of shared-nothing servers, and queries are answered using a distributed join algorithm. Although such solutions have been extensively studied in relational and RDF databases, we argue that existing approaches exhibit two drawbacks. First, they usually decide statically(i.e., at query compile time) how to shuffle the data, which can lead to missed opportunities for local computation. Second, they often materialise large intermediate relations whose size is determined by the entire dataset (and not the data stored in each server), so these relations can easily exceed the memory of individual servers. As a possible remedy, we present a novel distributed join algorithm for RDF. Our approach decides when to shuffle data dynamically, which ensures that query answers that can be wholly produced within a server involve only local computation. It also uses a novel flow control mechanism to ensure that every query can be answered even if each server has a bounded amount of memory that is much smaller than the intermediate relations. We complement our algorithm with a new query planning approach that balances the cost of communication against the cost of local processing at each server. Moreover, as in several existing approaches, we distribute RDF data using graph partitioning so as to maximise local computation, but we refine the partitioning algorithm to produce more balanced partitions. We show empirically that our techniques can outperform the state of the art by orders of magnitude in terms of query evaluation times, network communication, and memory use. In particular, bounding the memory use in individual servers can mean the difference between success and failure for answering queries with large answer sets.
Retinopathy of prematurity in babies weighing <1800 g; with special reference to babies weighing between 1501 and 1800 g: An experience from a tertiary care hospital in Delhi

Background: Retinopathy of prematurity (ROP) is a disease related to low birth weight, prematurity, oxygen administration, and various other factors, which are yet to be identified. Aims: The aim was to find incidence of ROP and risk factors for causation in babies weighing Design: Prospective study. Materials and Methods: Neonates weighing ≤1800 g taking birth in our institution from January 2011 to January 2012 for a span of 1 year; were included in the study. The data were analyzed to determine risk factors for ROP causation. Information was collected using the standardized performa which included the maternal risk factors as well. Infants were classified by ophthalmologic examination findings using ICROP revisited. Statistics: Qualitative data were analyzed using Pearson's Chi-square test with Yates correction or Fisher's exact test and possible risk factors were analyzed by univariate analysis and multivariate analysis. Results: A total of 278 subjects was included in the study. Incidence of ROP in babies ≤1800 g was found to be 13.67% (38/278). Incidence of ROP in babies weighing between 1501 and 1800 g was 11.64% (17/146). Twenty-one risk factors were significant on univariate analysis in babies weighing ≤1800 g and 18 risk factors in the babies weighing between 1501 and 1800 g. Multiple gestations ( P P P P P P P P Conclusion: It should be considered to incorporate screening of babies ≤1800 g uniformly in developing nations. It is recommended that further studies be done taking representative population of babies in different sites with adequate follow-up.
Trauma and psychophysiologic reactivity: menstrual phase, posttraumatic stress disorder, and performance on a loud tones task

v TABLE OF CONTENTS . vi LIST OF TABLES . vii LIST OF FIGURES . viii LIST OF ABBREVIATIONS . ix INTRODUCTION . 1 METHODS . 22 RESULTS . 30 DISCUSSION . 41 REFERENCES . 49 CURRICULUM VITAE . 62
Tunable Synthesis of SiC/SiO2 Heterojunctions via Temperature Modulation

A large-scale production of necklace-like SiC/SiO2 heterojunctions was obtained by a molten salt-mediated chemical vapor reaction technique without a metallic catalyst or flowing gas. The effect of the firing temperature on the evolution of the phase composition, microstructure, and morphology of the SiC/SiO2 heterojunctions was studied. The necklace-like SiC/SiO2 nanochains, several centimeters in length, were composed of SiC/SiO2 core-shell chains and amorphous SiO2 beans. The morphologies of the as-prepared products could be tuned by adjusting the firing temperature. In fact, the diameter of the SiO2 beans decreased, whereas the diameter of the SiC fibers and the thickness of the SiO2 shell increased as the temperature increased. The growth mechanism of the necklace-like structure was controlled by the vapor-solid growth procedure and the modulation procedure via a molten salt-mediated chemical vapor reaction process.
Impact of sleep characteristics and obesity on diabetes and hypertension across genders and menopausal status: the Nagahama study

Study Objectives The individual prevalence of sleep-disordered breathing (SDB), short sleep duration, and obesity is high and increasing. The study aimed to investigate potential associations between SDB, objective sleep duration, obesity, diabetes and hypertension across genders, and the effect of pre- or post-menopausal status. Methods A cross-sectional study evaluated 7051 community participants with wrist actigraphy for a week, and nocturnal oximetry ≥ 2 nights. SDB was assessed by 3 per cent oxygen desaturation index (ODI) corrected for sleep duration obtained from wrist actigraphy. Moderate-to-severe SDB was defined as ODI3% levels ≥ 15 per hour. Results Both logODI3% and body mass index showed independent negative associations with sleep duration (β = -0.16, p < 0.001 and β = -0.07, p < 0.001, respectively). Moderate-to-severe SDB (men/premenopausal women/postmenopausal women; 23.7/1.5/9.5%, respectively) was associated with a higher risk of diabetes in premenopausal women (OR 28.1; 95%CI 6.35-124.6; p < 0.001) and postmenopausal women (OR 3.25; 95%CI 1.94-5.46; p < 0.001), but not in men (OR 1.47; 95%CI 0.90-2.40; p = 0.119). Moderate-to-severe SDB was associated with a higher risk of hypertension in men (OR 3.11; 95%CI 2.23-4.33; p < 0.001), premenopausal women (OR 3.88; 95%CI 1.42-10.6; p = 0.008), and postmenopausal women (OR 1.96; 95%CI 1.46-2.63; p < 0.001). Short sleep duration was not associated with diabetes or hypertension. The associations of obesity with diabetes or hypertension were indirectly mediated by SDB (24.0% and 21.5%, respectively), with possible sex differences emerging (men/women; 15.3/27.8% and 27.0/16.9%, respectively). Conclusions Notwithstanding the cross-sectional design, SDB and obesity, but not short sleep duration, were independently associated with diabetes and hypertension, with gender and menopausal status-related differences in risk emerging.
Individualized prediction of trait narcissism from whole‐brain resting‐state functional connectivity

Narcissism is one of the most fundamental personality traits in which individuals in general population exhibit a large heterogeneity. Despite a surge of interest in examining behavioral characteristics of narcissism in the past decades, the neurobiological substrates underlying narcissism remain poorly understood. Here, we addressed this issue by applying a machine learning approach to decode trait narcissism from whole‐brain resting‐state functional connectivity (RSFC). Resting‐state functional MRI (fMRI) data were acquired for a large sample comprising 155 healthy adults, each of whom was assessed for trait narcissism. Using a linear prediction model, we examined the relationship between whole‐brain RSFC and trait narcissism. We demonstrated that the machine‐learning model was able to decode individual trait narcissism from RSFC across multiple neural systems, including functional connectivity between and within limbic and prefrontal systems as well as their connectivity with other networks. Key nodes that contributed to the prediction model included the amygdala, prefrontal and anterior cingulate regions that have been linked to trait narcissism. These findings remained robust using different validation procedures. Our findings thus demonstrate that RSFC among multiple neural systems predicts trait narcissism at the individual level.