Miracle-dz/UniFAR-FTUs huggingface dataset:
Radioligand Binding Properties and Pharmacological Characterization of 6-Amino-N-cyclohexyl-N,3-dimethylthiazolo[3,2-a]benzimidazole-2-carboxamide (YM-298198), a High-Affinity, Selective, and Noncompetitive Antagonist of Metabotropic Glutamate Receptor Type 1

Metabotropic glutamate receptor type 1 (mGluR1) is thought to play important roles in the neurotransmission and pathogenesis of several neurological disorders. Here, we describe the radioligand binding properties and pharmacological effects of a newly synthesized, high-affinity, selective, and noncompetitive mGluR1 antagonist, 6-amino-N-cyclohexyl-N,3-dimethylthiazolo[3,2-a]benzimidazole-2-carboxamide (YM-298198). YM-298198 inhibited glutamate-induced inositol phosphate production in mGluR1-NIH3T3 cells with an IC50 of 16 ± 5.8 nM in a noncompetitive manner. Its radiolabeled form, [3H]YM-298198, bound to mGluR1-NIH3T3 cell membranes with a KD of 32 ± 8.5 nM and a Bmax of 2297 ± 291 fmol/mg protein. In ligand displacement experiments using rat cerebellum membrane, an existing noncompetitive mGluR1 antagonist 7-(hydroxyimino)cyclo-propa[b]chromen-1a-carboxylate ethyl ester (CPCCOEt) competitively displaced [3H]YM-298198 binding, although glutamate and other mGluR1 ligands acting on a glutamate site failed to inhibit [3H]YM-298198 binding, suggesting that YM-298198 binds to CPCCOEt (allosteric) binding sites but not to glutamate (agonist) binding sites. Specificity was demonstrated for mGluR1 over mGluR subtypes 2 to 7, ionotropic glutamate receptors, and other receptor, transporter, and ion channel targets. In in vivo experiments, orally administered YM-298198 showed a significant analgesic effect in streptozotocin-induced hyperalgesic mice at doses (30 mg/kg) that did not cause Rotarod performance impairment, indicating that it is also useful even for in vivo experiments. In conclusion, YM-298198 is a newly synthesized, high-affinity, selective, and noncompetitive antagonist of mGluR1 that will be a useful pharmacological tool due to its highly active properties in vitro and in vivo. Its radiolabeled form [3H]YM-298198 will also be a valuable tool for future investigation of the mGluR1.
Boolean algebras, Stone spaces, and the iterated Turing jump

Abstract We show, roughly speaking, that it requires ω iterations of the Turing jump to decode nontrivial information from Boolean algebras in an isomorphism invariant fashion. More precisely, if α is a recursive ordinal, is a countable structure with finite signature, and d is a degree, we say that has αth-jump degreed if d is the least degree which is the αth jump of some degree c such there is an isomorphic copy of with universe ω in which the functions and relations have degree at most c. We show that every degree d ≥ 0(ω) is the ωth jump degree of a Boolean algebra, but that for n < ω no Boolean algebra has nth-jump degree d < 0(n). The former result follows easily from work of L. Feiner. The proof of the latter result uses the forcing methods of J. Knight together with an analysis of various equivalences between Boolean algebras based on a study of their Stone spaces. A byproduct of the proof is a method for constructing Stone spaces with various prescribed properties.
Please Scroll down for Article Journal of Sports Sciences Independence of Reaction Time and Response Force Control during Isometric Leg Extension Independence of Reaction Time and Response Force Control during Isometric Leg Extension

This article may be used for research, teaching and private study purposes. Any substantial or systematic reproduction, redistribution , reselling , loan or sub-licensing, systematic supply or distribution in any form to anyone is expressly forbidden. The publisher does not give any warranty express or implied or make any representation that the contents will be complete or accurate or up to date. The accuracy of any instructions, formulae and drug doses should be independently verified with primary sources. The publisher shall not be liable for any loss, actions, claims, proceedings, demand or costs or damages whatsoever or howsoever caused arising directly or indirectly in connection with or arising out of the use of this material. In this study, we examined the relative control of reaction time and force in responses of the lower limb. Fourteen female participants (age 21.2+1.0 years, height 1.62+0.05 m, body mass 54.1+6.1 kg; mean+s) were instructed to exert their maximal isometric one-leg extension force as quickly as possible in response to an auditory stimulus presented after one of 13 foreperiod durations, ranging from 0.5 to 10.0 s. In the 'irregular condition' each foreperiod was presented in random order, while in the 'regular condition' each foreperiod was repeated consecutively. A significant interactive effect of foreperiod duration and regularity on reaction time was observed (P 5 0.001 in two-way ANOVA with repeated measures). In the irregular condition the shorter foreperiod induced a longer reaction time, while in the regular condition the shorter foreperiod induced a shorter reaction time. Peak amplitude of isometric force was affected only by the regularity of foreperiod and there was a significant variation of changes in peak force across participants; nine participants were shown to significantly increase peak force for the regular condition (P 5 0.001), three to decrease it (P 5 0.05) and two showed no difference. These results indicate the independence of reaction time and response force control in the lower limb motor system. Variation of changes in peak force across participants may be due to the different attention to the bipolar nature of the task requirements such as maximal force and maximal speed.
Equivalence of Remote, Online Administration and Traditional, Face-to-Face Administration of Woodcock-Johnson IV Cognitive and Achievement Tests

Many children in need do not receive the mental health services they require. This is true with psychoeducational services in schools, where a shortage of school psychologists has been identified and an estimated 15% of all students struggle with attentional or learning difficulties that are unassessed and unaddressed, largely due to problems with access to psychoeducational evaluations. Remote, online psychoeducational evaluations have the potential to decrease this access problem by assisting school psychologists with their evaluation workload. The present study evaluated the equivalence of a remote, online administration procedure for the Woodcock-Johnson IV cognitive and achievement tests with traditional, in-person administration. Results revealed no significant differences between the scores on any index or individual test between the administration procedures. The remote, online procedure is a viable alternative for the traditional, in-person administration of the WJ IV, having the potential to improve psychoeducational evaluation access for many students across the country
A Random Feature Selection Approach for Neural Network Ensembles: Considering Diversity

The concept of ensemble feature selection has been raised by Optiz in his earlier work. And yet, for models like neural networks, new models should be trained and created for every change in its feature subspace, this problem may become tricky when evolutionary algorithms are used to select features, for the slow-training process of neural networks may dramatically extend the whole process of ensemble training. Given the success of a powerful ensemble approach - GASEN, a random feature selection method is adopted to solve this problem. Experiments show that this approach (GASEN-fs) not only accelerate the training of component networks but also enhance its generalization ability.
Cartilage Tissue Engineering with Silk Fibroin Scaffolds Fabricated by Indirect Additive Manufacturing Technology

Advanced tissue engineering (TE) technology based on additive manufacturing (AM) can fabricate scaffolds with a three-dimensional (3D) environment suitable for cartilage regeneration. Specifically, AM technology may allow the incorporation of complex architectural features. The present study involves the fabrication of 3D TE scaffolds by an indirect AM approach using silk fibroin (SF). From scanning electron microscopic observations, the presence of micro-pores and interconnected channels within the scaffold could be verified, resulting in a TE scaffold with both micro- and macro-structural features. The intrinsic properties, such as the chemical structure and thermal characteristics of SF, were preserved after the indirect AM manufacturing process. In vitro cell culture within the SF scaffold using porcine articular chondrocytes showed a steady increase in cell numbers up to Day 14. The specific production (per cell basis) of the cartilage-specific extracellular matrix component (collagen Type II) was enhanced with culture time up to 12 weeks, indicating the re-differentiation of chondrocytes within the scaffold. Subcutaneous implantation of the scaffold-chondrocyte constructs in nude mice also confirmed the formation of ectopic cartilage by histological examination and immunostaining.
A critical appraisal of the SED fitting method to estimate photometric redshifts

We discuss the stability of the photometric redshift estimate obtained with the SED fitting method with respect to the choice of the galaxy templates. Within the observational uncertainty and photometric errors, we find satisfactory agreement among different sets of theoretical and empirical templates using the Hubble Deep Field North as a target galaxy sample. Our results suggest that, especially at high redshift, the description of the physical processes of photon absorption in the interstellar and intergalactic medium plays a dominant role in the redshift estimate. The specific choice of the template set, as long as this includes both normal and starburst galaxies, is in comparison a minor issue.
Study of Cloud Based ERP Services for Small and Medium Enterprises (Data is Processed by Text Mining Technique)

— The purpose of this research paper is to explore the knowledge of the existing studies related to cloud computing current trend. The outcome of research is demonstrated in the form of diagram which simplifies the ERP integration process for in-house and cloud ecosystem. It will provide a conceptual view to the new client or entrepreneurs using ERP services and explain them how to deal with two stages of ERP systems (cloud and in-house). Also suggest how to improve knowledge about ERP services and implementation process for both stages. The work recommends which ERP services can be outsourced over the cloud. Cloud ERP is a mix of standard ERP services along with cloud flexibility and low cost to afford these services. This is a recent phenomenon in enterprise service offering. For most of non IT background entrepreneurs it is unclear and broad concept, since all the research work related to it are done in couple of years. Most of cloud ERP vendors describe their products as straight forward tasks. The process and selection of Cloud ERP Services and vendors is not clear. This research work draws a framework for selecting non-core business process from preferred ERP service partners. It also recommends which ERP services outsourced first over the cloud, and the security issues related to data or information moved out from company premises to the cloud ecosystem .
Psychic Trauma: Dynamics, Symptoms, and Treatment

Introducing a new hobby for other people may inspire them to join with you. Reading, as one of mutual hobby, is considered as the very easy hobby to do. But, many people are not interested in this hobby. Why? Boring is the reason of why. However, this feel actually can deal with the book and time of you reading. Yeah, one that we will refer to break the boredom in reading is choosing psychic trauma dynamics symptoms and treatment as the reading material.
The representation of the national quality framework in the australian print media: silences and slants in the mediatisation of early childhood education policy

ABSTRACT While research investigating the mediatisation of education policy has primarily been undertaken in school contexts, this paper reports on a study conducted in the context of early childhood education. The paper examines how a major policy in early childhood education in Australia – the National Quality Framework – has been mediatised in selected newspapers. Drawing on Foucauldian, critical discourse analysis and mediatisation theorising, we utilised the corpus linguistic tools of WordSmith Tools 6.0 to inform content analyses of 121 articles from two major media corporations, News Corp and Fairfax. Our findings highlight the utility of treating our data as two distinct corpora, with each corporation found to have utilised discursive technologies to proffer competing positionings of the Framework. The contested nature of the Framework – generally purported in Fairfax to be a tool that supports quality early education, as opposed to News Corp’s framing of the policy as one that inhibits affordable childcare – poses implications for which advocacy groups are regarded by the media as having authority and thus likely to influence policy through the reporting of their voices. Implications for newspaper media as a discursive influence on parents’ childcare decision-making are also considered.
The CNOC2 field galaxy redshift survey

The second Canadian Network for Observational Cosmology ( CNOC) galaxy redshift survey, CNOC2, is designed to investigate the relations between the dramatic evolution of field galaxies and their clustering over the redshift range 0 to 0.7. The sample of about 6000 galaxies with accurate velocities is spread over four sky patches with a total area of about 1.5deg2. Here we report preliminary results based on two of the sky patches and within the redshift range of 0.12 to 0.55. After classifying the galaxy spectral energy distributions relative to non–evolving references, we find that the early and intermediate–type populations can be described with nearly pure luminosity evolution, whereas the late–type population requires nearly pure density evolution. The spatial two–point correlation functions have a strong colour dependence with scale, and a weaker, apparently scale–free, luminosity dependence. The population most likely to be conserved with redshift is the high–luminosity galaxies. In particular, we choose galaxies with MRke ⩽−20 mag as our tracer population. We find that the evolution of the clustered density in proper co–ordinates at r ≲ 10h−1 Mpc, ρgg ∝ r0γ(1+z)3, is best described as a ‘de–clustering’, proportional to (1+z)0.6±0.4); or equivalently, there is a weak growth of clustering in co–moving co–ordinates, x0 ∝(1+z)(−0.3±0.2). This conclusion is supported by the pairwise peculiar velocities, which show no significant change with redshift. The cosmic virial theorem applied to the CNOC2 data gives Q3ΩM/b = 0.11 ± 0.04, where Q3 is the three–point correlation parameter and b the bias.
Dynamics of attention shifts in frontal eye fields and primary visual cortex as revealed by simultaneous recordings

Models of attention are based on the notion that top-down signals from frontal cortex influence the processing of information in early visual areas (Desimone and Duncan, 1995). The manner, through which such a putative interaction occurs, however, is not clear. We recorded the neuronal activity in the frontal eye fields (area FEF) and the primary visual cortex (area V1) while monkeys were performing a curve tracing task, which requires shifts of attention. In order to monitor neuronal interactions under different attentional demands we manipulated the task difficulty. We characterized the effects of attention by measuring the strength and the latency of attentional modulation in these areas. An increase in task difficulty resulted in reduction of strength and increased latencies of the attentional modulation in each area. We found that attentional modulation in area FEF was stronger than in area V1. The latency of modulation was, however, not significantly different between these two areas, which suggests they jointly participate in the attentional selection process during curve tracing. We also measured the correlation between the strengths of responses of neurons within area V1 and between V1 and area FEF. This so-called rate-covariation was stronger between pairs of recording sites within area V1 than across the two areas. The interareal rate-covariation between area FEF and V1 was stronger if the same curve fell in neurons' receptive fields compared to when different curves fell on the receptive fields. Moreover, the rate-covariation between neurons in different areas that coded the same curve was significantly affected by attention and task difficulty, being strongest when an easy stimulus that was attended stimulated the receptive fields. The pattern of rate-covariation points to an intricate communication network between FEF and V1 that is flexibly modulated by behavioural context.
Modeling Use Continuance Behavior in Microblogging Services: The Case of Twitter

The most popular microblogging service, Twitter, has established a large user base, in spite of numerous criticisms. This study aims to examine why this is the case. In particular, the study develops a model of microblogging use continuance based on theories of continuance, habit and critical mass. The model is then tested via a Web survey of Twitter users and PLS path modeling. The results suggest that continued use intention is strongly determined by perceived usefulness, satisfaction and habit (R2=0.454). The paper rounds off with conclusions and implications for future research and practice in this very new area of inquiry.
An Analytical Framework for Assessing Asset Pricing Models and Predictability

New insights about the connections between stock market volatility and returns, the pricing of long-run claims, or return predictability have recently revived interest in consumption-based equilibrium asset pricing. The recursive utility model is prominently used in these contexts to determine the price of assets in equilibrium. Often, solutions are approximate and quantities of interest are computed through simulations. We propose an approach that delivers closed-form formulas for price-consumption and price-dividend ratios, as well as for many of the statistics usually computed to assess the ability of the model to reproduce stylized facts. The proposed framework is flexible enough to capture rich dynamics for consumption and dividends. Closed-form formulas facilitate the economic interpretation of empirical results. We illustrate the usefulness of our approach by investigating the properties of long-run asset pricing models in many empirical dimensions.
Terminal twist induced continuous writhe of a circular rod with intrinsic curvature.

It is well known that a large linking number induces an abrupt writhing of a circular rod with zero intrinsic curvature, i.e., the stress-free state of the rod is straight. We show here that for any rod with a uniform natural curvature, no matter how small the intrinsic curvature is, a twist will induce a continuous writhing from the circular configuration and the abrupt writhing is only the limiting case when the intrinsic curvature is absolutely zero. The implication of this result on elastic models of circular DNA is discussed.
Best practices in business process redesign: use and impact

Purpose – This paper seeks to provide business process redesign (BPR) practitioners and academics with insight into the most popular heuristics to derive improved process designs.Design/methodology/approach – An online survey was carried out in the years 2003‐2004 among a wide range of experienced BPR practitioners in the UK and The Netherlands.Findings – The survey indicates that this “top ten” of best practices is indeed extensively used in practice. Moreover, indications for their business impact have been collected and classified.Research limitations/implications – The authors' estimations of best practices effectiveness differed from feedback obtained from respondents, possibly caused by the design of the survey instrument. This is food for further research.Practical implications – The presented framework can be used by practitioners to keep the various aspects of a redesign in perspective. The presented list of BPR best practices is directly applicable to derive new process designs.Originality/value.
Capturing Product Line Architectures

Although product line architectures serve an increasingly important role in the software development process, no representation currently exists in which they can be precisely captured. This position paper presents our work to date in addressing this problem. Specifically, we introduce a novel representation that can be used to specify the details of a product line architecture. The representation not only captures the variability that exists within a product line architecture, but also captures the evolution of the interfaces, components, and connections that constitute a product line architecture.
Plastic flow in solids with interfaces

A non‐equilibrium theory of isothermal and diffusionless evolution of incoherent interfaces within a plastically deforming solid is developed. The irreversible dynamics of the interface are driven by its normal motion, incoherency (slip and misorientation), and an intrinsic plastic flow, and purely by plastic deformation in the bulk away from the interface. Using the continuum theory for defect distribution (in bulk and over the interface) we formulate a general kinematical framework, derive relevant balance laws and jump conditions, and prescribe a thermodynamically consistent constitutive/kinetic structure for interface evolution. Copyright © 2012 John Wiley & Sons, Ltd.
The L2 rate of convergence for hazard regression

The logarithm of the conditional hazard function of a survival time given one or more covariates is approximated by a function having the form of a specified sum of functions of at most d of the variables. Subject to this form, the approximation is clhosein to imiaximnize the expected conditional log-likelihood. Maximumii likelihood and sums of tensor products of polynomial splines are used to construct an estimate of this approximation based on a random sample. The components of this estimate possess a rate of convergence that depends only on d and a suitably defined smoothness parameter.
IL-23 Is Required for the Development of Severe Egg-Induced Immunopathology in Schistosomiasis and for Lesional Expression of IL-171

In infection with the trematode helminth Schistosoma mansoni, the severity of CD4 T cell-mediated hepatic granulomatous and fibrosing inflammation against parasite eggs varies considerably in humans and among mouse strains. In mice, either the natural high pathology, or high pathology induced by concomitant immunization with schistosome egg Ags (SEA) in CFA (SEA/CFA), results from a failure to contain a net proinflammatory cytokine environment. We previously demonstrated that the induction of severe immunopathology was dependent on the IL-12/IL-23 common p40 subunit, and correlated with an increase in IL-17, thus implying IL-23 in the pathogenesis. We now show that mice lacking the IL-23-specific subunit p19 are impaired in developing severe immunopathology following immunization with SEA/CFA, which is associated with a marked drop of IL-17 in the granulomas, but not in the draining mesenteric lymph nodes, and with a markedly suppressed SEA-specific IFN-γ response regulated by a striking increase in IL-10. The granulomas are characterized by a significant reduction in Gr-1+ cell recruitment and by alternative macrophage activation. Taken together, these results demonstrate that IL-23 per se is not necessary for the generation of IL-17-producing T cells, but is essential for the development of severe schistosome egg-induced immunopathology, and its absence cannot be overcome with other possible compensatory mechanisms.