Miracle-dz/UniFAR-FTUs huggingface dataset:
Remotely sensed soil moisture over Australia from AMSR-E

Soil moisture can significantly influence atmospheric evolution. However the soil moisture state predicted by land surface models, and subsequently used as the boundary condition in atmospheric models, is often unrealistic. New remote sensing technologies are able to observe surface soil moisture at the scales and coverage required by numerical weather prediction (NWP), and there is potential to improve modelled soil moisture, and ultimately atmospheric forecasts, through assimilation of this remotely sensed data into NWP models.
Cooperation between Engulfment Receptors: The Case of ABCA1 and MEGF10

The engulfment of dying cells is a specialized form of phagocytosis that is extremely conserved across evolution. In the worm, it is genetically controlled by two parallel pathways, which are only partially reconstituted in mammals. We focused on the recapitulation of the CED-1 defined pathway in mammalian systems. We first explored and validated MEGF10, a novel receptor bearing striking structural similarities to CED-1, as a bona fide functional ortholog in mammals and hence progressed toward the analysis of molecular interactions along the corresponding pathway. We ascertained that, in a system of forced expression by transfection, MEGF10 function can be modulated by the ATP binding cassette transporter ABCA1, ortholog to CED-7. Indeed, the coexpression of either a functional or a mutant ABCA1 exerted a transdominant positive or negative modulation on the MEGF10-dependent engulfment. The combined use of biochemical and biophysical approaches indicated that this functional cooperation relies on the alternate association of these receptors with a common partner, endogenously expressed in our cell system. We provide the first working model structuring in mammals the CED-1 dependent pathway.
Emotional aging: a discrete emotions perspective

Perhaps the most important single finding in the field of emotional aging has been that the overall quality of affective experience steadily improves during adulthood and can be maintained into old age. Recent lifespan developmental theories have provided motivation- and experience-based explanations for this phenomenon. These theories suggest that, as individuals grow older, they become increasingly motivated and able to regulate their emotions, which could result in reduced negativity and enhanced positivity. The objective of this paper is to expand existing theories and empirical research on emotional aging by presenting a discrete emotions perspective. To illustrate the usefulness of this approach, we focus on a discussion of the literature examining age differences in anger and sadness. These two negative emotions have typically been subsumed under the singular concept of negative affect. From a discrete emotions perspective, however, they are highly distinct and show multidirectional age differences. We propose that such contrasting age differences in specific negative emotions have important implications for our understanding of long-term patterns of affective well-being across the adult lifespan.
Long-Term Effect of Photoperiod, Temperature and Feeding Regimes on the Respiration Rates of Antarctic Krill ( Euphausia superba )

Antarctic krill is thought to undergo an annual cycle of biological processes to cope with seasonal changes in their environment. The question of whether, and to what degree, seasonal environmental parameters such as photoperiod, food availability and temperature govern metabolism in krill is not clear. In this long-term laboratory study, respiration rates were determined in krill incubated under simulated natural light cycle or total darkness, subjected to fed or starved conditions and on krill kept at different temperatures (-1°C, 1°C and 3°C). There was a strong and significant increasing trend of respiration rates with month in all experimental treatments. In August (late winter), the mean respiration rates ranged between 0.22 - 0.35 μL O2 mg.DW-1.hr-1 for krill in both simulated seasonal light and complete darkness, and 0.25 - 0.26 μL O2 mg.DW-1.hr-1 for both fed and starved krill. Mean maximal respiration rates were recorded in October and December for all light and feeding treatments (0.46 - 0.56 μL O2 mg.DW-1.hr-1). Mean respiration rates for krill in the temperature treatments ranged between 0.24 - 0.30 μL O2 mg.DW-1.hr-1 in September reaching mean maximal rates in November and February (0.60 - 0.71 μL O2 mg.DW-1.hr-1). The covariate total length of krill was found to be non-significant and there was generally no significant interaction of experimental treatment with month and only for photoperiod comparison was the treatment main effect significant. The dark treatment gave higher respiration rates, and this needs careful interpretation. Results here suggest that, although light, food availability and temperature significantly affect metabolic rates, overal
Nitric oxide and blood: a review

Summary. Nitric oxide (NO) was identified as a physiological mediator of vascular tone in 1987. NO produced by endothelial cells causes vasodilatation and also inhibits platelet aggregation and leucocyte adhesion. Red cells metabolize NO to nitrate but may possibly carry and release, or even produce, NO in hypoxic conditions. NO physiology may have important implications for transfusion medicine, ranging from adverse effects of haemoglobin substitutes to preservation of stored platelets and to detrimental effects of stored red cells.
Changes in risk factors and their contribution to reduction of mortality risk following gastric bypass surgery among obese individuals with type 2 diabetes: a nationwide, matched, observational cohort study

Objective We recently showed that Roux-en-Y gastric bypass (RYGB) reduces risks of mortality, cardiovascular death and myocardial infarction in obese individuals compared with matched patients with diabetes mellitus (DM). We have examined changes in risk factors after RYGB, with the aim of explaining these effects. Research design and methods We matched (1:1) 6132 RYGB patients with DM reported to the Scandinavian Obesity Surgery Register with patients who had not undergone RYGB, based on sex, age, body mass index (BMI) and time, and assessed effects 2007–2014. We used causal mediation analysis to study effects mediated through changes to BMI and risk factors at 1 year based on Cox proportional hazards models. Results Baseline BMI was 42 kg/m2. Following RYGB, the lowest BMI was observed after 2 years (mean 31.9 kg/m2), and hemoglobin A1c (HbA1c) after 1 year (mean 6.32% (45.6 mmol/mol)). Maximum high-density lipoprotein (HDL) cholesterol was observed after 3–5 years (mean 1.46 mmol/L). Differences in BMI, HbA1c and HDL between the groups were statistically significant up to 6 years, and 2–3 years for low-density lipoprotein (LDL) and blood pressure, despite fewer glucose-lowering, hypertensive and lipid-lowering treatments. The causal mediation analysis suggested that RYGB has a positive effect on mortality risk, mainly by means of weight reduction (as opposed to changes to the risk factors analyzed). Conclusions Improvements in risk factors might contribute to the reduction of mortality risk after RYGB in obese individuals with type 2 diabetes, but the main effect seems to be mediated through a decrease in BMI, which could serve as a proxy for several mechanisms.
The Role of Transverse Occipital Sulcus in Scene Perception and Its Relationship to Object Individuation in Inferior Intraparietal Sulcus

The parietal cortex has been functionally divided into various subregions; however, very little is known about how these areas relate to each other. Two such regions are the transverse occipital sulcus (TOS) scene area and inferior intraparietal sulcus (IPS). TOS exhibits similar activation patterns to the scene selective parahippocampal place area, suggesting its role in scene perception. Inferior IPS, in contrast, has been shown to participate in object individuation and selection via location. Interestingly, both regions have been localized to the same general area of the brain. If these two were actually the same brain region, it would have important implications regarding these regions' role in cognition. To explore this, we first localized TOS and inferior IPS in individual participants and examined the degree of overlap between these regions in each participant. We found that TOS showed only a minor degree of overlap with inferior IPS (∼10%). We then directly explored the role of TOS and inferior IPS in object individuation and scene perception by examining their responses to furnished rooms, empty rooms, isolated furniture, and multiple isolated objects. If TOS and inferior IPS were the same region, we would expect to see similar response patterns in both. Instead, the response of TOS was predominantly scene selective, whereas activity in inferior IPS was primarily driven by the number of objects present in the display, regardless of scene context. These results show that TOS and inferior IPS are nearby but distinct regions, with different functional roles in visual cognition.
Resource Provisioning Policies to Increase IaaS Provider's Profit in a Federated Cloud Environment

Cloud Federation is a recent paradigm that helps Infrastructure as a Service (IaaS) providers to overcome resource limitation during spikes in demand for Virtual Machines (VMs) by outsourcing requests to other federation members. IaaS providers also have the option of terminating spot VMs, i.e, cheaper VMs that can be canceled to free resources for more profitable VM requests. By both approaches, providers can expect to reject less profitable requests. For IaaS providers, pricing and profit are two important factors, in addition to maintaining a high Quality of Service (QoS) and utilization of their resources to remain in the business. For this, a clear understanding of the usage pattern, types of requests, and infrastructure costs are necessary while making decisions to terminate spot VMs, outsourcing or contributing to the federation. In this paper, we propose policies that help in the decision-making process to increase resources utilization and profit. Simulation results indicate that the proposed policies enhance the profit, utilization, and QoS (smaller number of rejected VM requests) in a Cloud federation environment.
cis9, trans11-Conjugated Linoleic Acid Differentiates Mouse 3T3-L1 Preadipocytes into Mature Small Adipocytes through Induction of Peroxisome Proliferator-activated Receptor γ

Dietary conjugated linoleic acid (CLA) has been reported to exhibit a number of therapeutic effects in animal models and patients, such as anti-hypertensive, anti-hyperlipidemic, anti-arteriosclerotic, anti-carcinogenic, and anti-diabetic effects. However, the underlying mechanism is not well-characterized. In the present study, the effects of cis(c)9, trans(t)11-CLA on the differentiation of mouse 3T3-L1 preadipocytes into mature adipocytes were examined. Treatment with c9, t11-CLA in the presence of insulin, dexamethasone, and 3-isobutyl-1-methyl-xanthine (differentiation cocktail) significantly stimulated the accumulation of triacylglycerol. The microscopic observation of cells stained by Oil Red O demonstrated that c9, t11-CLA increases the amount and proportion of small mature adipocytes secreting adiponectin, a benign adipocytokine, when compared to the differentiation cocktail alone. Furthermore, c9, t11-CLA increased bioactive peroxisome proliferator-activated receptor γ (PPARγ) levels in a nuclear extract of 3T3-L1 cells, suggesting the enhancing effect of this fatty acid on the nuclear transmission of PPARγ, a master regulator of adipocyte differentiation, in 3T3-L1 cells. These results suggest that the therapeutic effects of c9, t11-CLA on lifestyle-related diseases are partially due to the enhanced formation of small adipocytes from preadipocytes via PPARγ stimulation.
Joint Effects of Dietary Vitamin D and Sun Exposure on Breast Cancer Risk: Results from the French E3N Cohort

Background: Ecological studies have suggested that vitamin D production through ultraviolet (UV) solar irradiance could reduce breast cancer (BC) risk. Although studies restricted to dietary vitamin D intake have provided inconsistent results, little is known about the relationship between pre- and postmenopausal BC and combined intakes from diet, supplements, and sun exposure. Methods: Cox proportional hazards regression models evaluated the association between vitamin D intakes, mean daily ultraviolet radiation dose (UVRd) at the place of residence and risk of BC among 67,721 women of the French E3N cohort. All analyses were stratified on menopausal status taking into account important confounders including calcium consumption. Results: During 10 years of follow-up, a total of 2,871 BC cases were diagnosed. Dietary and supplemental vitamin D intakes were not associated with BC risk; however, in regions with the highest UVRd, postmenopausal women with high dietary or supplemental vitamin D intake had a significantly lower BC risk as compared with women with the lowest vitamin D intake (HR = 0.68, 95% CI: 0.54–0.85, and HR = 0.57, 95% CI: 0.36–0.90, respectively). Conclusion: Our results suggest that a threshold of vitamin D exposure from both sun and diet is required to prevent BC and this threshold is particularly difficult to reach in postmenopausal women at northern latitudes where quality of sunlight is too poor for adequate vitamin D production. Impact: Prospective studies should further investigate associations between BC risk, vitamin D status and sunlight exposure. Cancer Epidemiol Biomarkers Prev; 20(1); 187–98. ©2011 AACR.
Reach enhancement of 100% for a DP-64QAM super-channel using MC-DBP

A digital coherent super-receiver enables the reception and demodulation of a 7×10GBd DP-64QAM Nyquist spaced super-channel. Multi-channel DBP provides a 100% improvement in reach from 640km to 1280km of SSMF, with an ISD of 9.15b/s/Hz.
The specific entropy of elliptical galaxies: an explanation for profile‐shape distance indicators?

Dynamical systems in equilibrium have a stationary entropy; we suggest that ellipti- cal galaxies, as stellar systems in a stage of quasi-equilibrium, may have in principle a unique specific entropy. This uniqueness, a priori unknown, should be reflected in correlations between the fundamental parameters describing the mass (light) distribu- tion in galaxies. Following recent photometrical work on elliptical galaxies (Caon et al. 1993; Graham & Colless 1997; Prugniel & Simien 1997), we use the Sersic law to describe the light profile and an analytical approximation to its three dimensional de- projection. The specific entropy is then calculated supposing that the galaxy behaves as a spherical, isotropic, one-component system in hydrostatic equilibrium, obeying the ideal gas state equations. We predict a relation between the 3 parameters of the Sersic law linked to the specific entropy, defining a surface in the parameter space, an 'Entropic Plane', by analogy with the well-known Fundamental Plane. We have analysed elliptical galaxies in two rich clusters of galaxies (Coma and ABCG 85) and a group of galaxies (associated with NGC 4839, near Coma). We show that, for a given cluster, the galaxies follow closely a relation predicted by the constant specific entropy hypothesis with a typical dispersion (one standard deviation) of 9.5% around the mean value of the specific entropy. Moreover, assuming that the specific entropy is also the same for galaxies of different clusters, we are able to derive relative distances between Coma, ABGC 85, and the group of NGC 4839. If the errors are only due to the determination of the specific entropy (about 10%), then the error in the relative distance determination should be less than 20% for rich clusters. We suggest that the unique specific entropy may provide a physical explanation for the distance indicators based on the Sersic profile put forward by Young & Currie (1994, 1995) and recently discussed by Binggeli & Jerjen (1998).
Pathology Consultation on Influenza Diagnostics

Abstract Objectives: To describe the strengths and limitations of the available influenza diagnostics, with a focus on rapid antigen detection assays and nucleic acid detection assays. Methods: A case-based presentation is used to illustrate the potential limitations of rapid antigen detection assays for influenza. Results: Influenza is a seasonal illness; estimates attribute influenza to approximately 200,000 hospitalizations and 41,000 deaths in the United States annually. Antigen detection assays for influenza are rapid and convenient, and thus are widely used in a variety of health care settings, even though the sensitivity of these assays may be suboptimal. The United States Food and Drug Administration has recently created new guidelines intended to improve the oversight and performance characteristics of influenza antigen detection assays. Molecular assays, although more costly and complex, are more sensitive and may be designed to simultaneously detect multiple respiratory pathogens within a single assay. Conclusions: Diagnostic assays for influenza can vary greatly with regards to analytical performance characteristics, complexity, turnaround time and cost. This can have important patient care and infection prevention implications.
Acetabular cartilage assessment in patients with femoroacetabular impingement by using T2* mapping with arthroscopic verification.

PURPOSE To evaluate the ability of T2* mapping to help differentiate damaged from normal acetabular cartilage in patients with femoroacetabular impingement (FAI). MATERIALS AND METHODS The institutional review board approved this retrospective study, and the requirement to obtain informed consent was waived. The study complied with HIPAA guidelines. The authors reviewed T2* relaxation time maps of 28 hips from 26 consecutive patients (mean patient age, 28.2 years; range, 12-53 years; eight male patients (nine hips) with a mean age of 26.7 years [range, 16-53 years]; 18 female patients (19 hips) with a mean age of 28.9 years [range, 12-46 years]). Conventional diagnostic 3.0-T magnetic resonance (MR) arthrography was augmented by including a multiecho gradient-recalled echo sequence for T2* mapping. After imaging, acetabular and femoral data were separated and acetabular regions of interest were identified. Arthroscopic cartilage assessment with use of a modified Beck scale for acetabular cartilage damage was performed by an orthopedic surgeon who was blinded to the results of T2* mapping. A patient-specific acetabular projection with a T2* overlay was developed to anatomically correlate imaging data with those from surgery (the standard of reference). Results were analyzed by using receiver operating characteristic (ROC) curves. RESULTS The patient-specific acetabular projection enabled co-localization between the MR imaging and arthroscopic findings. T2* relaxation times for normal cartilage (Beck score 1, 35.3 msec ± 7.0) were significantly higher than those for cartilage with early changes (Beck score 2, 20.7 msec ± 6.0) and cartilage with more advanced degeneration (Beck scores 3-6, ≤19.8 msec ± 5.6) (P < .001). At ROC curve analysis, a T2* value of 28 msec was identified as the threshold for damaged cartilage, with a 91% true-positive and 13% false-positive rate for differentiating Beck score 1 cartilage (normal) from all other cartilages. CONCLUSION The patient-specific acetabular projection with a T2* mapping overlay enabled good anatomic localization of cartilage damage defined with a T2* threshold of 28 msec and less.
On the interaction of a racing car front wing and exposed wheel

Abstract A numerical investigation of generic open-wheel racing car wing and wheel geometry has been conducted, using original sub-scale experimental data for validation. It was determined that there are three main interactions that may occur, identifiable by the path that the main and secondary wing vortices take around the wheel. Interaction ‘A’ occurs when the main and secondary wing vortices both travel outboard of the wheel; interaction ‘B’ is obtained when only the main wing vortex passes inboard of the wheel; while interaction ‘C’ sees both wing vortices travel inboard of the wheel. The different interactions are achieved when geometric changes to the wing affect the pressure distribution about the endplate, either by altering the magnitude of suction generated by the wing or by changing the locations of peak suction and vortices relative to the wheel’s stagnation regions. As a result, the influence that the wing and wheel have on each other – in comparison to the same bodies in isolation – varies, resulting in significant consequences for downforce and drag.
Source localization with isotropic arrays

We consider the effect of unknown signal propagation velocity on direction-of-arrival (DOA) estimation performance using an array of sensors. For general arrays, the DOA estimation variance, as measured by the Crame/spl acute/r-Rao bound (CRB), degrades when the propagation velocity is unknown. In this letter, we show that for both two- and three-dimensional arrays, the CRB on the DOA angle is independent of whether or not the propagation velocity is known if and only if the sensor locations satisfy the isotropy conditions given in earlier work. The results hold for both narrowband and wideband signals.
Serum Amyloid P Component Binding to Shiga Toxin 2 Requires Both A Subunit and B Pentamer

ABSTRACT Solid-phase binding, competitive binding, and cytotoxicity neutralization assays indicate that the B pentamer and A subunit both contribute to human serum amyloid P (HuSAP) component binding to Stx2. A polyvalent globotriaosyl-ceramide receptor analog, Daisy, did not competitively inhibit HuSAP binding, implying that the two ligands bind to different Stx2 domains.
Retention Protocols and Use of Vacuum-formed Retainers among Specialist Orthodontists

Objective To evaluate retention protocols and use of vacuum-formed retainers (VFRs) among specialist orthodontists. Design Postal/electronic (e-) questionnaire. Setting Republic of Ireland. Participants Members of the Dental Council of Ireland Specialist Register of Orthodontists and/or Orthodontic Society of Ireland. Methods A pilot-tested questionnaire was distributed to 123 eligible specialist orthodontists. Questions addressed respondent demographics, preferred retainer choice in the maxillary and mandibular arches, prescribed wear protocols, VFR characteristics and factors influencing retainer choice. Statistical analyses were performed using PASW® version 18. Results The response rate was 82%. VFRs were the most commonly chosen retainer, prescribed by 53% of respondents in the maxilla and 33% in the mandible. Full-time followed by part-time wear of removable retainers (RRs) was the wear protocol favoured by the majority (70–76%). Full occlusal coverage was the VFR design favoured by 93%. VFR sheet thicknesses of 1.0 mm (68%) and 0.75 mm (16%) were most commonly prescribed. Seventeen per cent were aware that their patients used their VFRs as a receptacle for dental bleaching gel. Life-time wear of retainers was advised by 67–78%. The operator factor that most influenced retainer choice was the pre-treatment situation (88%). Conclusions VFRs were the most common retainer choice in the maxilla and mandible with full-time wear followed by part-time wear of RRs favoured by most. Full occlusal coverage with a thickness of 1.0 mm was the VFR design prescribed by the majority. More than one in six specialist orthodontists were aware that their patients used their VFRs as a receptacle for dental bleaching gel.