Miracle-dz/UniFAR-FTUs huggingface dataset:
Constructing the processes involved in ending therapy with clients

Understanding the processes involved in therapy are crucial to maximising its benefits. This doctoral thesis explores two aspects of therapy which are crucial to the beginning and ending phases of therapy i.e. the formation of the therapeutic relationship and the experience of ending therapy. It is hoped that this contribution to the research base will provide clinicians with practical recommendations based on empirical evidence and prompt future research to investigate these topics further. The first section of this thesis describes a metasynthesis of qualitative studies exploring the formation of the therapeutic relationship from the client’s perspective. Findings highlight clients’ initial assessment of therapist characteristics to see whether they fit with their perceived needs. Displays of openness and respect from the therapist were found to facilitate the formation of the relationship and allow for a deep connection between client and therapist to be established. The second section of this thesis presents a grounded theory study focusing on therapists’ experiences of ending therapy with clients. The theory explains the processes that play a significant role in the ending experience (therapist context, therapeutic approach, level of connectedness, level of investment and therapist’s perceived responsibility) and how they impact on different types of therapy endings. Elements of the therapy were found to continue beyond the final session as therapists described learning from each ending experience which served to influence their future work with clients. The third section of this thesis comprises personal reflections on the process of engaging in the thesis project. Specifically, this critical appraisal explores the difficulties experienced by the author in positioning herself within a consistent ontological and epistemological stance. The reflections offered in this section follow the developmental journey made by the author as a result of engaging in this project.
Global Analysis of Gel Mobility of Proteins and Its Use in Target Identification*

SDS-PAGE is a basic method that has long been used for separation of proteins according to their molecular sizes. Despite its simplicity, it provides information on characteristics of proteins beyond their molecular masses because gel mobility of proteins often reflects their physicochemical properties and post-translational modifications. Here we report on a global analysis of gel mobility of the proteome, which we term the “mobilitome,” covering 93.4% of the fission yeast proteome. To our surprise, more than 40% of proteins did not migrate to their calculated positions. Statistical analyses revealed that the discrepancy was largely dependent on the hydrophobicity of proteins. This experimental data set, with a high coverage rate of real mobility, made it feasible to identify proteins detected on the gel without using any specialized techniques. This approach enabled us to detect previously unknown post-translational modifications of a protein; for example, we revealed that eIF5A is novel substrate of a Sir2-related deacetylase Hst2. Furthermore, we concomitantly identified twelve acetylated and eight methylated proteins using specific anti-acetylated and anti-methylated lysine antibodies, most of which had not been known to be subject to the modifications. Thus, we propose the general usefulness of the mobilitome and electrophoresis-based methodology for the identification and characterization of proteins detected on the gel.
Real-time vector velocity assessment through multigate doppler and plane waves

Several ultrasound (US) methods have been recently proposed to produce 2-D velocity vector fields with high temporal and spatial resolution. However, the real-time implementation in US scanners is heavily hampered by the high calculation power required. In this work, we report a real-time vector Doppler imaging method which has been integrated in an open research system. The proposed approach exploits the plane waves transmitted from two sub-arrays of a linear probe to estimate the velocity vectors in 512 sample volumes aligned along the probe axis. The method has been tested for accuracy and reproducibility through simulations and in vitro experiments. Simulations over a 0° to 90° angle range of a 0.5 m/s peak parabolic flow have yielded 0.75° bias and 1.1° standard deviation for direction measurement, and 0.6 cm/s bias with 3.1% coefficient of variation for velocity assessment. In vitro tests have supported the simulation results. Preliminary measurements on the carotid artery of a volunteer have highlighted the real-time system capability of imaging complex flow configurations in an intuitive, easy, and quick way, as shown in a sample supplementary movie. These features have allowed reproducible peak velocity measurements to be obtained, as needed for quantitative investigations on patients.
Interpolatory Weighted-H 2 Model Reduction

This paper introduces an interpolation framework for the weighted-H2 model reduction problem. We obtain a new representation of the weighted-H2 norm of SISO systems that provides new interpolatory first order necessary conditions for an optimal reduced-order model. The H2 norm representation also provides an error expression that motivates a new weighted-H2 model reduction algorithm. Several numerical examples illustrate the effectiveness of the proposed approach.
Hepatic lipase C-480T polymorphism modifies the effect of HDL cholesterol on the risk of acute myocardial infarction in men: a prospective population based study

Previous studies have revealed an inverse association between high density lipoprotein cholesterol (HDL-C) levels and the risk of acute myocardial infarction (AMI). 1,2 HDL-C level is modulated by genetic factors as well as environmental factors such as obesity, smoking, and physical exercise. Hepatic lipase (HL) is a lipolytic enzyme in lipoprotein metabolism, functioning as a phospholipase, an acylglycerol hydrolase, and a ligand of cell surface glycosaminoglycans, hydrolysing triglyceride-rich lipoprotein particles.3 Recently, it has been reported that HL is synthesised by macrophages.4 The HL gene variation has a significant effect on the variability of HDL-C in the population.5,6 The functional HL promoter C-480T transition, also referred to as (-514C/T), leads to three common genotypes: CC, CT, and TT. The C and T alleles are associated with high and low HL activity, respectively.7–9 However, the common polymorphisms of HL (-480T), cholesterol ester transfer protein (CETP) (TaqIB), lipoprotein lipase (S447X), and lecithin cholesterol acyl transferase (S208T) contribute only about 2.5% to the variance of HDL-C in the population.10 This suggests that the HL C-480T polymorphism and HDL-C levels are different factors, and studying their interaction is justified. One previous study has shown that there might be an interaction between CETP gene polymorphism and HDL-C on the risk of myocardial infarction.11 This result raises the possibility that other polymorphisms associated with HDL-C—for example, HL gene polymorphism—might interact with HDL-C and thus modify the risk of AMI. In fact, an effect of the C-480T polymorphism on coronary artery disease (CAD) has been sought in several studies with both negative7,12 and positive findings.13–15 One possible reason for the mixed results may be the interaction between HL C-480T genotype and HDL levels on CAD, a hypothesis not studied previously. To address this question, and …
Changing Pattern of Hepatitis A Virus Epidemiology in an Area of High Endemicity

Background Continuous assessment of hepatitis A virus (HAV) seroepidemiology is a useful tool to control the risk of infection. Objectives This study aimed to evaluate the changing patterns of anti-HAV seroprevalence in a population,which isgenerally considered to be anarea ofhigh endemicity. Patients and Methods Overall, the results of 3349 sera collected during the period 2005-2008 from patients attending the University Hospital of Cagliari, Italy were studied; their mean age was 52.7 years, (s + 16.22). Patients with liver disease were excluded from the study. Age specific seroprevalence results were compared with those observed in similar previous studies carried out in the same area. Results The overall prevalence of anti-HAV was 74.6% with consistently lower values in subjects younger than 40 years (17.5%; P < 0.0001) particularly in those under 30 years of age (8.9%, CI 5.8-11.9). A significant declining trend in age specific seroprevalence has been foundin people under 30 years;61% in 1988, 33% in 1995 and 8.9% in 2005-2008. Conclusions Our findings show that a significant decline inherd immunity has occurred in the last 20 years as a consequence of lower HAV circulation due to improvementsin socio-economical and hygienic conditions. Adolescents and young adults are becoming increasingly susceptible to HAV infections, as recent outbreaks of acute HAV hepatitis have occurred. Persistent environmental monitoring and the implementation of prevention measures must be considered in order to contain the risk related to this epidemiological shift.
Benchmark Tests for the DARPA Spoken Language Program

This paper documents benchmark tests implemented within the DARPA Spoken Language Program during the period November, 1992 January, 1993. Tests were conducted using the Wall Street Journal-based Continuous Speech Recognition (WSJ-CSR) corpus and the Air Travel Information System (ATIS) corpus collected by the Multi-site ATIS Data COllection Working (MADCOW) Group. The WSJ-CSR tests consist of tests of large vocabulary (lexicons of 5,000 to more than 20,000 words) continuous speech recognition systems. The ATIS tests consist of tests of (1) ATIS-domain spontaneous speech (lexicons typically less than 2,000 words), (2) natural language understanding, and (3) spoken language understanding. These tests were reported on and discussed in detail at the Spoken Language Systems Technology Workshop held at the Massachusetts Institute of Technology, January 20-22, 1993.
The role of family, peers and school perceptions in predicting involvement in youth violence

This study explored the relative importance of family, peers and school in predicting youth violence. The analysis was done on a nationally representative sample included 8,394 students from grade 6th-10th in Israel. Measures of youth violence included bullying, physical fights and weapon carrying. The findings suggested that all three social systems had significant relations with youth violence, respectively. Variables found to predict violence were: Family-lack of parental support regarding school; Peers-Lack of social integration or too many evenings out with friends; School-feeling of school alienation, low academic achievement and perceptions of frequent acts of violence in school. School perceptions had the strongest predicting power. Findings emphasized the importance of focusing on improving the daily school experience in reducing youth violence.
The use of International Classification of Functioning, Disability and Health in motor neurone disease rehabilitation

2 Declaration . 4 Preface . 5 Acknowledgments . 7 Table of contents . 8 List of publications (peer-reviewed) . 13 Glossary . 14 Glossary of abbreviations. 16 List of tables . 18 List of boxes . 20 Chapter 1 – Thesis Introduction . 21 1.1 Issues in the care of patients with MND . 23 1.2 Barriers which affect the development and implementation of recommendations in the care of patients with MND . 24 1.3 Hypothesis . 25 1.4 Objectives . 26 1.5 Overview of Methods (see Figure 1.2) . 26 1.5. 1 Setting and Participants . 27 1.6 Overview of the thesis . 30 Chapter 2 Motor Neurone Disease: Causes, Classification and Treatments . 31 2.
Knowledge Transfer in Information Systems Support Community: Network Effects of Bridging and Reaching

The support of a new information system in an organization is a knowledge-intensive setting (which we refer to as an IS support community) where IS professionals engage in frequent knowledge sharing activities with organizational users and provide users with knowledge, diagnoses and solutions in a timely manner. In this paper, we drew upon perspectives from social networks and knowledge transfer literature to specifically examine two network characteristics of an IS support community – bridging and reaching – and their effects on knowledge transfer. Bridging is examined through Burt’s (1992) structural holes. Reaching is examined through Valente and Forman’s (1998) measure of radiality, a variation of closeness centrality measure. Effect of knowledge transfer is captured through an IS support professional’s productivity measured as the ticket resolution time. We collected archival data comprising 11,409 system usage problem records reported by 2,000+ users in the supply chain function over a 10-month post-implementation period of a new enterprise system in a large U.S. organization. We analyzed the data using social network analysis and analysis of covariance. Our results show strong support for our hypotheses that network bridging and reaching are positively related to an IS support professional’s productivity. Our study has important implications for IS theory and practice.
Thrombin potently enhances swelling‐sensitive glutamate efflux from cultured astrocytes

High concentrations of thrombin (Thr) have been linked to neuronal damage in cerebral ischemia and traumatic brain injury. In the present study we found that Thr markedly enhanced swelling‐activated efflux of 3H‐glutamate from cultured astrocytes exposed to hyposmotic medium. Thr (0.5–5 U/mL) elicited small 3H‐glutamate efflux under isosmotic conditions and increased the hyposmotic glutamate efflux by 5‐ to 10‐fold, the maximum effect being observed at 15% osmolarity reduction. These Thr effects involve its protease activity and are fully mimicked by SFFLRN, the synthetic peptide activating protease‐activated receptor‐1. Thr potentiation of 3H‐glutamate efflux was largely dependent on a Thr‐elicited increases in cytosolic Ca2+ (Ca2+i) concentration ([Ca2+]i). Preventing Ca2+i rise by treatment with EGTA‐AM or with the phospholipase C blocker U73122 reduced the Thr‐increased glutamate efflux by 68%. The protein kinase C blockers Go6976 or chelerythrine reduced the Thr effect by 19%–22%, while Ca/calmodulin blocker W7 caused a 63% inhibition. In addition to this Ca2+‐sensitive pathway, Thr effect on glutamate efflux also involved activation of phosphoinositide‐3 kinase (PI3K), since it was reduced by the PI3K inhibitor wortmannin (51% inhibition). Treating cells with EGTA‐AM plus wortmannin essentially abolished Thr‐dependent glutamate efflux. Thr‐activated glutamate release was potently inhibited by the blockers of the volume‐sensitive anion permeability pathway, NPPB (IC50 15.8 μM), DCPIB (IC50 4.2 μM). These results suggest that Thr may contribute to the excitotoxic neuronal injury by elevating extracellular glutamate release from glial cells. Therefore, this work may aid in search of neuroprotective strategies for treating cerebral ischemia and brain trauma. © 2007 Wiley‐Liss, Inc.
Inequalities in children's energy balance-related behaviours: a European perspective

Background: It is well known that the prevalence of overweight and obesity is considerably higher among youth from lower socio-economic families, but there is little information about the role of some energy balance-related behaviours in the association between socio-economic status and childhood overweight and obesity. The objective of this paper was to assess the possible mediation role of energy balance-related behaviours in the association between parental education and children’s body composition. Methods: Data were obtained from the cross sectional study of the “EuropeaN Energy balance Research to prevent excessive weight Gain among Youth” (ENERGY) project. 2121 boys and 2516 girls aged 10 to 12 from Belgium, Greece, Hungary, the Netherlands, Norway, Slovenia and Spain were included in the analyses. Data were obtained via questionnaires assessing obesity related dietary, physical activity and sedentary behaviours and basic anthropometric objectively measured indicators (weight, height, waist circumference). The possible mediating effect of sugared drinks intake, breakfast consumption, active transportation to school, sports participation, TV viewing, computer use and sleep duration in the association between parental education and children’s body composition was explored via MacKinnon’s product-of-coefficients test in single and multiple mediation models. Two different body composition indicators were included in the models, namely Body Mass Index and waist circumference. Results: the association between parental education and children’s body composition was partially mediated by breakfast consumption, sports participation, TV viewing and computer use. Additionally, a suppression effect was found for sugared drinks intake. No mediation effect was found for active transportation and sleep duration. The significant mediators explained a higher proportion of the association between parental education and waist circumference compared to the association between parental education and BMI. Conclusions: tailored overweight and obesity prevention strategies in low SES preadolescent populations should incorporate specific messages focusing on the importance of encouraging daily breakfast consumption, increasing sports participation and decreasing TV viewing and computer use. However, longitudinal research to support these findings is needed.
Phytochemical and Biological Studies of Total Ethanol and Petroleum Ether Extracts of Terminalia Bentzoe ( L . ) Leaves

Terminalia is a genus of Combretaceous plants extensively distributed in tropical and subtropical areas. Numerous species of this genus have been utilized for medicinal purposes because of their valuable phytoconstituents. This study aimed to compare between the phytoconstituents of the hydroalcoholic extract (HAE) of Terminalia bentzone (T. bentzoe) leaves as polar extract and its petroleum ether extract (PEE) as a nonpolar extract. Concerning this, total phenolics, flavonoids, proteins and carbohydrate content of the HAE were estimated. HPLC analysis of HAE revealed identification of nine phenolic acids, two flavonoids and one anthocyanin, they were gallic, ellagic, pyrogallol, catechin, chlorogenic acid, synergic acid, pyrocatechol, cinnamic acid, paraqumaric acid, caffeic acid, quercetin and rutin arranged according to the order of elution. Colum chromatographic separation of HAE resulted in the isolation of six compounds for the first time named: gallic acid, ellagic methyl gallate catechin, rutin and quercetin. On the other hand, the PEE was fractionated to saponifiable and unsaponifiable fractions and both fractions were analysed by GC/MS. The GC/MS analysis of the saponifiable fraction revealed the identification of thirty-seven compounds as fatty acid methyl esters representing 83.51% of the total fraction, methyl hexadecanoate (39.98%) constitutes the major fatty acid methyl ester followed by methyl octadecanoate (6.62%). The analysis of the unsaponifiable fraction disclosed the presence of fortynine compounds representing 72.32% of the total compounds, where butylated hydroxyl toluene (10.03%) constitutes the major compound. Both HAE and PEE were evaluated for their in vitro antioxidant potential by DPPH and β-carotene methods. The HAE superiors PEE in its antioxidant potentiality. Correspondingly, the HAE was subdued for further investigation embracing its in vivo antioxidant and antihyperlipidemic activities.
Hospital admissions due to adverse drug reactions. A report from the Boston Collaborative Drug Surveillance Program.

In 260 (3.7%) of 7,017 medical patients, an adverse drug reaction either caused or strongly influenced admission to the hospital, according to the admitting physician. The five drugs that were most commonly implicated as causes of hospital admission were digoxin (42 patients), aspirin (24), prednisone (15), warfarin sodium (9), and guanethidine sulfate (5); 113 other drugs were implicated. The five most common adverse events were digitalis intoxication (46 patients), gastrointestinal bleeding (24), hypoglycemia (13), rash (13), and gastritis (12). Since a major segment of the outpatient population that is served by the wards monitored in this study consume large amounts of many drugs, adverse drug reactions requiring hospitalization for any one drug are uncommon.
Spectral analysis and preconditioning techniques for radial basis function collocation matrices

Meshless collocation methods based on radial basis functions lead to structured linear systems, which, for equispaced grid points, have almost a multilevel Toeplitz structure. In particular, if we consider partial differential equations (PDEs) in two dimensions, then we find almost (up to a ‘low‐rank’ correction given by the boundary conditions) two‐level Toeplitz matrices, i.e. block Toeplitz with Toeplitz blocks structures, where both the number of blocks and the block‐size grow with the number of collocation points. In Bini et al. (Linear Algebra Appl. 2008; 428:508–519), upper bounds for the condition number of the Toeplitz matrices approximating a one‐dimensional model problem were proved. Here, we refine the one‐dimensional results, by explaining some numerics reported in the previous paper, and we show a preliminary analysis concerning conditioning, extremal spectral behavior, and global spectral results in the two‐dimensional case for the structured part. By exploiting the recent tools in the literature, a global distribution theorem in the sense of Weyl is proved also for the complete matrix‐sequence, where the low‐rank correction due to the boundary conditions is taken into consideration. The provided spectral analysis is then applied to design effective preconditioning techniques in order to overcome the ill‐conditioning of the matrices. A wide numerical experimentation, both in the one‐ and two‐dimensional cases, confirms our analysis and the robustness of the proposed preconditioners. Copyright © 2011 John Wiley & Sons, Ltd.
NUSTAR AND SUZAKU X-RAY SPECTROSCOPY OF NGC 4151: EVIDENCE FOR REFLECTION FROM THE INNER ACCRETION DISK

We present X-ray timing and spectral analyses of simultaneous 150 ks Nuclear Spectroscopic Telescope Array (NuSTAR) and Suzaku X-ray observations of the Seyfert 1.5 galaxy NGC 4151. We disentangle the continuum emission, absorption, and reflection properties of the active galactic nucleus (AGN) by applying inner accretion disk reflection and absorption-dominated models. With a time-averaged spectral analysis, we find strong evidence for relativistic reflection from the inner accretion disk. We find that relativistic emission arises from a highly ionized inner accretion disk with a steep emissivity profile, which suggests an intense, compact illuminating source. We find a preliminary, near-maximal black hole spin a > 0.9 ? > accounting for statistical and systematic modeling errors. We find a relatively moderate reflection fraction with respect to predictions for the lamp post geometry, in which the illuminating corona is modeled as a point source. Through a time-resolved spectral analysis, we find that modest coronal and inner disk reflection (IDR) flux variation drives the spectral variability during the observations. We discuss various physical scenarios for the IDR model and we find that a compact corona is consistent with the observed features.