Miracle-dz/UniFAR-FTUs huggingface dataset:
The Role of Conscious Reasoning and Intuition in Moral Judgment

Is moral judgment accomplished by intuition or conscious reasoning? An answer demands a detailed account of the moral principles in question. We investigated three principles that guide moral judgments: (a) Harm caused by action is worse than harm caused by omission, (b) harm intended as the means to a goal is worse than harm foreseen as the side effect of a goal, and (c) harm involving physical contact with the victim is worse than harm involving no physical contact. Asking whether these principles are invoked to explain moral judgments, we found that subjects generally appealed to the first and third principles in their justifications, but not to the second. This finding has significance for methods and theories of moral psychology: The moral principles used in judgment must be directly compared with those articulated in justification, and doing so shows that some moral principles are available to conscious reasoning whereas others are not.
Spatial Subsystem of Moral Metaphors: A Cognitive Semantic Study

Abstract Cognitive semantic studies have shown that our conceptualization of morality is at least partially metaphorical and that our moral cognition is grounded in some fundamental contrastive categories of our embodied experience in the physical environment. It is argued that our moral cognition is built on a moral metaphor system. Within the framework of conceptual metaphor theory, this study aims to examine the spatial subsystem of moral metaphors in English. We set out with five pairs of moral metaphors that involve the following spatial source concepts: HIGH and LOW, UPRIGHT and TILTED, LEVEL and UNLEVEL, STRAIGHT and CROOKED, and BIG and SMALL. These metaphors were found to constitute the spatial subsystem of moral metaphors in Chinese. Our primary goal is to find out if the five pairs of moral–spatial metaphors are manifested in English as well. To that end we collected linguistic data from the Corpus of Contemporary American English and searched Google Images for multimodal evidence. Our finding is that the five pairs of moral–spatial metaphors are applicable in English as they are in Chinese. We also discuss issues related to conceptual metaphor theory.
Point-Based Impostors for Real-Time Visualization

We present a new data structure for encoding the appearance of a geometric model as seen from a viewing region (view cell). This representation can be used in interactive or real-time visualization applications to replace a complex model by an impostor, maintaining high quality rendering while cutting down rendering time. Our approach relies on an object-space sampled representation similar to a point cloud or a layered depth image, but introduces two fundamental additions to previous techniques. First, the sampling rate is controlled to provide sufficient density across all possible viewing conditions from the specified view cell. Second, a correct, antialiased representation of the plenoptic function is computed using Monte Carlo integration. Our system therefore achieves high quality rendering using a simple representation with bounded complexity. We demonstrate the method for an application in urban visualization.
A highly robust and versatile finite element-boundary integral hybrid code for scattering by BOR objects

In this paper, we present such a simulation technique that combines the finite element and boundary integral (FE-BI) methods but with a significant improvement and expansion in its capability. This technique correctly models the boundary conditions along the axis of revolution in both the finite element and boundary integral formulations and yields highly accurate solutions. Because of the decoupled computations for the finite element and boundary integral equations, the technique is very efficient as compared to the MoM, especially for BORs comprising layered or inhomogeneous materials.
Using Mixed-Effects Modeling to Analyze Different Grain-Sized Skill Models in an Intelligent Tutoring System

Student modeling and cognitive diagnostic assessment are important issues that need to be addressed for the development and successful application of intelligent tutoring systems (ITS). ITS needs the construction of complex models to represent the skills that students are using and their knowledge states, and practitioners want cognitively diagnostic information at a finer grained level. Traditionally, most assessments treat all questions on the test as sampling a single underlying knowledge component. Can we have our cake and eat it, too? That is, can we have a good overall prediction of a high stakes test, while at the same time be able to tell teachers meaningful information about fine-grained knowledge components? In this paper, we introduce an online intelligent tutoring system that has been widely used. We then present some encouraging results about a fine-grained skill model with the system that is able to predict state test scores. This model allows the system track about 106 knowledge components for eighth grade math. In total, 921 eighth grade students were involved in the study. We show that our fine-grained model could improve prediction compared to other coarser grained models and an IRT-based model. We conclude that this intelligent tutoring system can be a good predictor of performance.
An Administrative Claims Model for Profiling Hospital 30-Day Mortality Rates for Pneumonia Patients

Background Outcome measures for patients hospitalized with pneumonia may complement process measures in characterizing quality of care. We sought to develop and validate a hierarchical regression model using Medicare claims data that produces hospital-level, risk-standardized 30-day mortality rates useful for public reporting for patients hospitalized with pneumonia. Methodology/Principal Findings Retrospective study of fee-for-service Medicare beneficiaries age 66 years and older with a principal discharge diagnosis of pneumonia. Candidate risk-adjustment variables included patient demographics, administrative diagnosis codes from the index hospitalization, and all inpatient and outpatient encounters from the year before admission. The model derivation cohort included 224,608 pneumonia cases admitted to 4,664 hospitals in 2000, and validation cohorts included cases from each of years 1998–2003. We compared model-derived state-level standardized mortality estimates with medical record-derived state-level standardized mortality estimates using data from the Medicare National Pneumonia Project on 50,858 patients hospitalized from 1998–2001. The final model included 31 variables and had an area under the Receiver Operating Characteristic curve of 0.72. In each administrative claims validation cohort, model fit was similar to the derivation cohort. The distribution of standardized mortality rates among hospitals ranged from 13.0% to 23.7%, with 25th, 50th, and 75th percentiles of 16.5%, 17.4%, and 18.3%, respectively. Comparing model-derived risk-standardized state mortality rates with medical record-derived estimates, the correlation coefficient was 0.86 (Standard Error = 0.032). Conclusions/Significance An administrative claims-based model for profiling hospitals for pneumonia mortality performs consistently over several years and produces hospital estimates close to those using a medical record model.
Interactive Space Deformation with Hardware-Assisted Rendering

The authors introduce a new approach for the deformation of surface and raster models in two and three dimensions. Rather than deforming the model, they deform the agents employed to render it. The method uses one deformation tool (the deflector) to deform any object that is ray traceable. Based on deforming the rendering primitives rather than objects, the approach invests computation effort only in those regions of the model that contribute to the final image.
FREQUENCY DEPENDENT SIGNAL TRANSFER IN NEURON TRANSISTORS

Nerve cells are attached to open, metal-free gates of field-effect transistors submersed in electrolyte. The intracellular voltage is modulated by small ac signals from 0.1 Hz to 5000 Hz using a patch-clamp technique. The source-drain current is affected in amplitude and phase through a modulation of the extracellular voltage in the cleft between transistor and cell. The ac-signal transfer is evaluated on the basis of linear response theory. We use the model of a planar two-dimensional cable which consists of the core of an electrolyte sandwiched between the coats of a cell membrane and silicon dioxide of the transistor surface. Comparing experiment and model we obtain the resistances of core and coat, i.e., of the seal of cell and surface and of the attached membrane. The resistance of the membrane varies in different junctions. It may be lowered by two orders of magnitude as compared with the free membrane. This drop of the membrane resistance correlates with an enhancement of the seal resistance, i.e., with closer adhesion. The linear ac-transfer functions are used to compute the signal transfer of an action potential. The computed response is in good agreement with the observations of excited nerve cells on transistors.
Nickel chloride (NiCl2) in hepatic toxicity: apoptosis, G2/M cell cycle arrest and inflammatory response

Up to now, the precise mechanism of Ni toxicology is still indistinct. Our aim was to test the apoptosis, cell cycle arrest and inflammatory response mechanism induced by NiCl2 in the liver of broiler chickens. NiCl2 significantly increased hepatic apoptosis. NiCl2 activated mitochondria-mediated apoptotic pathway by decreasing Bcl-2, Bcl-xL, Mcl-1, and increasing Bax, Bak, caspase-3, caspase-9 and PARP mRNA expression. In the Fas-mediated apoptotic pathway, mRNA expression levels of Fas, FasL, caspase-8 were increased. Also, NiCl2 induced ER stress apoptotic pathway by increasing GRP78 and GRP94 mRNA expressions. The ER stress was activated through PERK, IRE1 and ATF6 pathways, which were characterized by increasing eIF2α, ATF4, IRE1, XBP1 and ATF6 mRNA expressions. And, NiCl2 arrested G2/M phase cell cycle by increasing p53, p21 and decreasing cdc2, cyclin B mRNA expressions. Simultaneously, NiCl2 increased TNF-α, IL-1β, IL-6, IL-8 mRNA expressions through NF-κB activation. In conclusion, NiCl2 induces apoptosis through mitochondria, Fas and ER stress-mediated apoptotic pathways and causes cell cycle G2/M phase arrest via p53-dependent pathway and generates inflammatory response by activating NF-κB pathway.
The Challenges of Restoring Binaural Hearing: A Study of Binaural Fusion, Listening Effort, and Music Perception in Children using Bilateral Cochlear Implants

Benefits from bilateral implantation vary and are limited by mismatched devices, stimulation schemes, and abnormal development. We asked whether bilateral implant use promotes binaural fusion, reduces listening effort, or enhances music perception in children. Binaural fusion (perception of 1 vs. 2 sounds) was assessed behaviourally and reaction times and pupillary changes were recorded simultaneously to measure effort. The child's Montreal Battery of Evaluation of Amusia was modified and administered to evaluate music perception. Bilaterally implanted children heard a fused percept less frequently than normal hearing peers, possibly due to impaired cortical integration and device limitations, but fusion improved in children who were older and had less brainstem asymmetry and when there was a level difference. Poorer fusion was associated with increased effort, which may have resulted from diminished bottom-up processing. Children with bilateral implants perceived music as accurately as unilaterally implanted peers and improved performance with greater bilateral implant use. iii Acknowledgments I would not have been able to persevere through this process without continual support and encouragement from many important people in my life. I am especially thankful for the time and dedication of the children who participated in this study and their families (Figure 4.1). These incredible individuals have been a constant source of inspiration and have motivated me to pursue a career as a clinician-scientist. My Family – I am grateful to my parents, Sam and Shoshanah, for never doubting me and always giving me the courage and confidence to face any challenge. I would definitely not be where I am, or who I am, today if it were not for their immeasurable guidance, support, faith, and love. I am grateful to my sister, Dr. Mirisse Foroughe, for igniting my interest in psychology from a young age, never ceasing to stimulate my imagination, and for supporting me throughout this project. Contributions I am very grateful for the opportunity to be part of such a cohesive and talented team at the Cochlear Implant Laboratory at the Hospital for Sick Children. My Research Supervisor – I am grateful to Dr. Karen Gordon for introducing me to the fascinating world of cochlear implant research, teaching me to think critically, and showing me that I can accomplish more than I ever thought was possible with the right amount of motivation and effort. I would like to thank Dr. Gordon for allowing me to be a member of her incredible team, always …
Measuring Web site quality improvements: a case study of the forum on strategic management knowledge exchange

As organizations have begun increasingly to communicate and interact with consumers via the Web, so the appropriate design of offerings has become a central issue. Attracting and retaining consumers requires acute understanding of the requirements of users and appropriate tailoring of solutions. Recently, the development of Web offerings has moved beyond the commercial domain to government, both national and international. This paper examines the results of a quality survey of a Web site provided by the OECD. The site is examined before and after a major redesign process. The instrument, WebQual, draws on previous work in Web site usability, information quality, and service interaction quality to provide a rounded framework for assessing e‐commerce and e‐government offerings. The metrics and findings demonstrate not only the strengths and weaknesses of the sites, but also the different impressions of users in member countries. These findings have implications for e‐government Web site offerings.
Deep brain stimulation of the subthalamic nucleus: anatomical, neurophysiological, and outcome correlations with the effects of stimulation

Objectives: Bilateral chronic high frequency stimulation of the subthalamic nucleus (STN), through the stereotactical placement of stimulating electrodes, effectively improves the motor symptoms of severe Parkinson's disease. Intraoperative neurophysiological and clinical monitoring techniques (neuronal electrical activity recording and intraoperative stimulation) may improve and refine the localisation of the nucleus. The objective of this work was to compare the preoperative CT and MRI localisation with the intraoperative neurophysiological identification of STN. The relation between the localisation of the STN and the position of the most effective contact of the permanent quadripolar electrode at a 3 month and 1 year follow up was also studied. Methods: Fourteen consecutive parkinsonian patients were submitted to bilateral implant for STN stimulation. All the patients underwent a standard MRI and stereotactic CT to obtain, by image fusion and localisation software, the stereotactical coordinates of STN. The STN extension and boundaries were identified by a semimicrorecording of the neuronal electrical activity. The definitive quadripolar electrode was positioned to locate at least two contacts within the STN recording area. Intraoperative macrostimulation was performed to confirm the correct position of the electrode. Postoperative clinical evaluation of the effects of stimulation was checked for each contact of the quadripolar electrode testing the improvement on contralateral rigidity to select the best contact. This evaluation was repeated at 3 months and 1 year after surgery. Results: In 35.7% of the procedures it was necessary to perform more than one track to get a recording of neuronal activity consistent with STN. The mean position of the central point of all the 28 STN recording areas in respect of the AC-PC line midpoint was 2.7 mm posterior (SD 0.7), 3.8 mm inferior (SD 1.1), and 11.6 mm lateral (SD 0.9), and the mean distance between the anatomical target and the central point of the STN as defined by intraoperative recording was 0.5 mm (SD 0.5) on the anteroposterior plane, 0.7 mm (SD 0.7) on the lateral plane, and 0.9 mm (SD 0.6) on the vertical plane. At 1 year the mean position of the central point of the most effective contact of the electrode in respect of the AC-PC line midpoint was 1.7 mm posterior (SD 0.9), 1.7 mm inferior (SD 1.5), and 12.3 mm lateral (SD 0.9). Conclusion: The results highlight the role of the intraoperative recording to get a more accurate localisation of the STN in surgery for Parkinson's disease, allowing the identification of the boundaries and of the extension of the nucleus. The most effective contact of the quadripolar electrode was always in the upper part of the STN recording area or immediately above it, suggesting a role of this region in the clinical effectiveness of the STN electrical stimulation.
Role of blood cells in leucine kinetics across the human kidney.

To evaluate the role of blood cells in interorgan amino acid transport and in the estimates of regional protein turnover, we studied the effects of plasma vs. whole blood sampling on regional leucine kinetics in postabsorptive humans. Studies were carried out by combining the arteriovenous difference technique with the measurement of [14C]- and [15N]leucine isotope exchange across the human kidney, the splanchnic area, and the leg. In the kidney, whole blood-derived rates of leucine-carbon appearance, disappearance, and net balance (NB) were greater (by 3-15 times; P < 0.035) than those calculated in plasma. In addition, the net leucine-carbon (i.e., protein) balance across the kidney was negative in whole blood (-5.6 +/- 1.3 micromol/min x 1.73 m2, P < 0.01 vs. 0) but neutral in plasma [-0.24 +/- 1.33, P = not significant from 0; P < 0.01 vs. whole blood]. A net leucine transport out of renal cells was shown in blood but not in plasma. In contrast, rates of leucine-carbon appearance, disappearance, NB, and net transport, in both the splanchnic area and the leg, were similar in whole blood and plasma. These data suggest that blood cells play a key role in leucine transport out of the kidney and, consequently, in the leucine-derived estimates of renal protein degradation and NB, which is at variance with what is observed across the splanchnic organs or the leg. These data also emphasize the need for complete whole blood arteriovenous measurements to accurately estimate protein turnover across the kidney.
The Empirical Risk-Return Relation: A Factor Analysis Approach

A key criticism of the existing empirical literature on the risk-return relation relates to the relatively small amount of conditioning information used to model the conditional mean and conditional volatility of excess stock market returns. To the extent that financial market participants have information not reflected in the chosen conditioning variables, measures of conditional mean and conditional volatility--and ultimately the risk-return relation itself--will be misspecified and possibly highly misleading. We consider one remedy to these problems using the methodology of dynamic factor analysis for large datasets, whereby a large amount of economic information can be summarized by a few estimated factors. We find that three new factors, a "volatility," "risk premium," and "real" factor, contain important information about one-quarter ahead excess returns and volatility that is not contained in commonly used predictor variables. Moreover, the factor-augmented specifications we examine predict an unusual 16-20 percent of the one-quarter ahead variation in excess stock market returns, and exhibit remarkably stable and strongly statistically significant out-of-sample forecasting power. Finally, in contrast to several pre-existing studies that rely on a small number of conditioning variables, we find a positive conditional correlation between risk and return that is strongly statistically significant, whereas the unconditional correlation is weakly negative and statistically insignificant.
X-ray narrow emission lines from the nuclear region of NGC 1365

NGC 1365 is a Seyfert 2 galaxy with a starburst ring in its nuclear region. In this work we look at the XMM Reflection Grating Spectrometer (RGS) data from four 2012-13, three 2007 and two 2004 observations of NGC 1365. We characterise the narrow-line emitting gas visible by XMM RGS and make comparisons between the 2012-13 spectra and those from 2004-07, already published. This source is usually absorbed within the soft X-ray band, with a typical neutral column density of >1.5 x 10$^{23}$ cm$^{-2}$, and only 1 observation of the 9 we investigate shows low enough absorption for the continuum to emerge in the soft X-rays. We stack all observations from 2004-07, and separately three of the four observations from 2012-13, analysing the less absorbed observation separately. We first model the spectra using gaussian profiles representing the narrow line emission. We fit physically motivated models to the 2012-13 stacked spectra, with collisionally ionised components representing the starburst emission and photoionised line emission models representing the AGN line emission. The collisional and photoionised emission line models are fitted together on top of a physical continuum and absorption model. The X-ray narrow emission line spectrum of NGC 1365 is well represented by a combination of two collisionally ionised and three photoionised phases of emitting gas, all with higher than solar nitrogen abundances. This physical model was fitted to the 2012-13 stacked spectrum, and yet also fits well to the 2004-07 stacked spectrum, without changing any characteristics of the emitting gas phases. Our 2004-07 results are consistent with previous emission line work using these data, with 5 additional emission lines detected in both this and the 2012-13 stacked spectra. We also estimate the distance of the X-ray line-emitting photoionised gas from the central source to be <300 pc.
CYP2C19*2 and Other Allelic Variants Affecting Platelet Response to Clopidogrel Tested by Thrombelastography in Patients with Acute Coronary Syndrome

Background:To investigate the contributions of CYP2C19 polymorphisms to the various clopidogrel responses tested by thrombelastography (TEG) in Chinese patients with the acute coronary syndrome (ACS). Methods:Patients were screened prospectively with ACS diagnose and were treated with clopidogrel and aspirin dual antiplatelet therapy. CYP2C19 loss of function (LOF) and gain of function (GOF) genotype, adenosine 5′-diphosphate (ADP)-channel platelet inhibition rate (PIR) tested by TEG and the occurrence of 3-month major adverse cardiovascular events and ischemic events were assessed in 116 patients. Results:High on-treatment platelet reactivity (HTPR) prevalence defined by PIR <30% by TEG in ADP-channel was 32.76% (38/116). With respect to the normal wild type, CYP2C19*2, and *3 LOF alleles, and *17 GOF alleles, patients were classified into three metabolism phenotypes: 41.38% were extensive metabolizers (EMs), 56.90% were intermediate metabolizers (IMs), and 1.72% were poor metabolizers (PMs). Of the enrolled patients, 31.47%, 5.17%, and 0.43%, respectively, were carriers of *2, *3, and *17 alleles. The HTPR incidence differed significantly according to CYP2C19 genotypes, accounting for 18.75%, 41.54%, and 100.00% in EMs, IMs, and PMs, respectively. Eighteen (17.24%) ischemic events occurred during the 3-month follow-up, and there was a significant difference in ischemic events between HTPR group and nonhigh on-treatment platelet reactivity group. Conclusions:Genetic CYP2C19 polymorphisms are relative to the inferior, the antiplatelet activity after clopidogrel admission and may increase the incidence of ischemic events in patients with ACS.