Miracle-dz/UniFAR-FTUs huggingface dataset:
Expanding maps of an interval with holes

We study a class of open chaotic dynamical systems. Consider an expanding map of an interval from which a few small open subintervals are removed (thus creating ‘holes’). Almost every point of the original interval then eventually escapes through the holes, so there can be no absolutely continuous invariant measures. We construct a so-called conditionally invariant measure that is equivalent to the Lebesgue measure. Our measure is unique and naturally generates an invariant measure, which is singular. These results generalize early work by Pianigiani, Yorke, Collet, Martinez, and Schmidt, who studied similar maps under an additional Markov assumption. We do not assume any Markov property here and use ‘bounded variation’ techniques rather than Markov coding. Our results supplement those of Keller, who studied analytic interval maps with holes by using different techniques.
Topical Review Examining the evidence of psychological treatments for chronic pain: time for a paradigm

NOTICE: this is the author’s version of a work that was accepted for publication in PAIN. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in PAIN, vol 154, Issue 10, 2013 DOI: 10.1016/j.pain. 2013.05. 049
Rescuing memristor-based computing with non-linear resistance levels

Emerging memristor devices like metal oxide resistive switching random access memory (RRAM) and memristor crossbar have shown great potential in computing matrix-vector multiplication. However, due to the nonlinear distribution of resistance levels in memristor devices, the state-of-the-art multi-bit cell cannot accomplish the multi-bit computing task accurately. In this paper, we propose fault-tolerant schemes to rescue memristor-based computation with nonlinear resistance levels. We classify the resistance level distributions in memristor devices into three types, and the corresponding models are proposed to analyze the computation characteristics. We propose two theoretical conditions to determine if a memristor device can support multi-bit matrix computation. For the deviated linear model, the least squares method is used to reduce the computing error. When the resistance distribution obeys the proposed power model, a logarithmic operation circuit is used to decode the multiplication results and then accomplish the computing accurately. For the exponential model, since the device cannot complete typical matrix-vector multiplication from hardware level, we propose online and offline quantization methods to make the neural computing algorithms friendly to memristor device. Simulation results show that the root-mean-square error improves around 4% with the linear model and more than 99% with the power model. After quantization, the accuracy of ResNet-18 using memristor with exponential conductance levels can be improved to the same accuracy with ideal linear devices.
Acceptability of tenofovir gel as a vaginal microbicide among women in a phase I trial: a mixed-methods study.

OBJECTIVES In this phase I safety trial of tenofovir gel, a candidate vaginal microbicide for human immunodeficiency virus (HIV) prevention, a mixed-methods design was used to gather acceptability data among women participants. The impact of acceptability factors on use of the gel and the relationship between qualitative and quantitative acceptability data are explored. METHODS Participants included low-risk, HIV-uninfected, and clinically stable HIV-infected women. Participants were enrolled into cohorts stratified by HIV serostatus, sexual activity, gel concentration, and frequency of use. Quantitative data were collected via interviewer-administered structured questionnaires. Qualitative data were collected via semistructured small group discussions. RESULTS Although 94% of participants stated they would "probably" or "definitely" use tenofovir gel, a range of responses emerged on multiple domains relevant to microbicide acceptability during the qualitative discussions. Lubrication, leakage, sexual pleasure, and the possibility of covert use were central to women's qualitative assessments of tenofovir gel. CONCLUSIONS Quantitative results indicate that tenofovir vaginal gel was acceptable to almost all users, while qualitative findings indicate that acceptability is complex, varies among users, and is likely shaped by a variety of contextual factors that manufacturers will need to consider to optimize use-effectiveness. Because of the differences in the qualitative and quantitative responses, the authors argue that future trials of candidate microbicides should include strategic collection of mixed-methods microbicide acceptability data.
Simpson’s paradox – aggregating and partitioning populations in health disparities of lung cancer patients

It is well known that non-small cell lung cancer (NSCLC) is a heterogeneous group of diseases. Previous studies have demonstrated genetic variation among different ethnic groups in the epidermal growth factor receptor (EGFR) in NSCLC. Research by our group and others has recently shown a lower frequency of EGFR mutations in African Americans with NSCLC, as compared to their White counterparts. In this study, we use our original study data of EGFR pathway genetics in African American NSCLC as an example to illustrate that univariate analyses based on aggregation versus partition of data leads to contradictory results, in order to emphasize the importance of controlling statistical confounding. We further investigate analytic approaches in logistic regression for data with separation, as is the case in our example data set, and apply appropriate methods to identify predictors of EGFR mutation. Our simulation shows that with separated or nearly separated data, penalized maximum likelihood (PML) produces estimates with smallest bias and approximately maintains the nominal value with statistical power equal to or better than that from maximum likelihood and exact conditional likelihood methods. Application of the PML method in our example data set shows that race and EGFR-FISH are independently significant predictors of EGFR mutation.
The Prevalence of Chronic Diseases by Exposure to Nitrates from Environmental Factors

Abstract The study aims to analyze the health effects caused by chronic exposure to elevated levels of nitrates in the water in order to improve prevention of some diseases. We analyze water quality from two villages of Constanta County in the period 2006-2012 and we take data about chronic diseases from family doctors of these localities. Analyzes on water samples were made in the laboratory of the Public Health Department. We found a significant increase of prevalence for chronic diseases in locality exposed to nitrates.
Electrical Parasitic Bandwidth Limitations of Oxide-Free Lithographic Vertical-Cavity Surface-Emitting Lasers

In the past several decades, oxide-confined vertical-cavity surface-emitting lasers (VCSELs) have made success in competition with etched-post-type VCSELs and proton implanted VCSELs, and become the most popular optical sources in short-reach data communications. In the commercial oxide VCSEL technology, an oxide aperture is created inside resonant cavity in realizing good mode and current confinement, however, high electrical resistance comes along with forming the oxide aperture and the electrical parasitic bandwidth becomes the main limitation in modulation speed. Other drawbacks exist in oxide VCSELs, including difficulty in control of small aperture size, large internal stress and high thermal resistance. To overcome the disadvantages, oxide-free lithographic VCSELs have been proposed and demonstrated. In this report, electrical bandwidths of oxide-free lithographic VCSELs have been studied along with their general lasing properties. Due to the new ways of fabricating the aperture, record low resistances have been achieved in oxide-free lithographic VCSELs with various sizes, while high slope efficiencies and high output powers have been maintained. High speed simulation has been performed showing the very low differential resistances will benefit much to the electrical parasitic bandwidths, and are expected to produce higher modulation speed. A bottom emitting structure has been proposed and analyzed, showing reduction in both mirror resistance and capacitance will further improve the modulation speed. The total 3-dB modulation bandwidth is expected to be 50-77 GHz, much higher than the bandwidth reached in existing oxide VCSELs. Lithographic VCSELs also show superior lasing characteristics, including record low thermal resistance and record high output power. The maximum power exceeds 19 mW in a 6 μm device and over 50 % power conversion efficiency has been achieved. A maximum single mode
Homocysteine , vitamins , and vascular disease prevention 1 – 3

In mid-20th century United States, deaths from vascular disease reached a peak incidence in 1955, but little was known about the underlying causes of this epidemic of disease. The significance of homocysteine in human disease was unknown until 1962, when cases of homocystinuria were first associated with vascular disease. Analysis of an archival case of homocystinuria from 1933 and a case of cobalamin C disease from 1968 led to the conclusion that homocysteine causes vascular disease by a direct effect of the amino acid on arterial cells and tissues. The homocysteine theory of arteriosclerosis attributes one of the underlying causes of vascular disease to elevation of blood homocysteine concentrations as the result of dietary, genetic, metabolic, hormonal, or toxic factors. Dietary deficiency of vitamin B-6 and folic acid and absorptive deficiency of vitamin B-12, which result from traditional food processing or abnormal absorption of B vitamins, are important factors in causing elevations in blood homocysteine. Numerous clinical and epidemiologic studies have established elevated blood homocysteine as a potent independent risk factor for vascular disease in the general population. Dietary improvement, providing abundant vitamin B-6, folic acid, and cobalamin, may prevent vascular disease by lowering blood homocysteine. The dramatic decline in cardiovascular mortality in the United States since 1950 may possibly be attributable in part to voluntary fortification of the food supply with vitamin B-6 and folic acid. Fortification of the US food supply with folic acid in 1998, as mandated by the US Food and Drug Administration, was associated with a further decline in mortality from vascular disease, presumably because of increased blood folate and decreased blood homocysteine in the population. Am J Clin Nutr 2007;
The Role of Lipid Peroxidation in Aluminium Toxicity in Soybean Cell Suspension Cultures

The primary reactions leading to Al toxicity in plant cells have not yet been elucidated. We used soybean ( Glycine max [L.] Merr.) cell suspension cultures to address the question whether lipid peroxidation plays an important role in Al toxicity. Upon transfer to an Alcontaining culture medium with a calculated Al3+ activity of 15 μᴍ soybean cells showed a distinct and longtime increase in lipid peroxidation within 4h. At the same time a drastic loss of cell viability was observed. Butylated hydroxyanisole (BHA) and N,N′-diphenyl-pphenylenediamine (DPPD), two lipophilic antioxidants, were able to almost completely suppress lipid peroxidation in Al-treated cells at a concentration of 20 μᴍ. This effect was dosedependent for DPPD and was observed at minimum concentrations of 1 -2 μᴍ. When lipid peroxidation was suppressed by DPPD or BHA cell viability remained high even in the presence of toxic Al concentrations. These results suggest that Al-induced enhancement of lipid peroxidation is a decisive factor for Al toxicity in suspension cultured soybean cells.
Semantic Language Models for Topic Detection and Tracking

In this work, we present a new semantic language modeling approach to model news stories in the Topic Detection and Tracking (TDT) task. In the new approach, we build a unigram language model for each semantic class in a news story. We also cast the link detection subtask of TDT as a two-class classification problem in which the features of each sample consist of the generative log-likelihood ratios from each semantic class. We then compute a linear discriminant classifier using the perceptron learning algorithm on the training set. Results on the test set show a marginal improvement over the unigram performance, but are not very encouraging on the whole.
Detection of Myocardial Bridging by 64-Row Computed Tomography Angiography of the Coronaries

Introduction: Myocardial bridging is a congenital condition in which a section of coronary artery is surrounded by myocardium. Historically, myocardial bridging has been diagnosed by catheter angiography. This study investigates the effectiveness of electrocardiogram-gated 64-slice multidetector computed tomography in detecting myocardial bridging. Materials and Methods: We retrospectively reviewed 167 consecutive patients referred for coronary computed tomography angiography between January 4, 2005, and May 24, 2006. We recorded the number of coronary segments exhibiting myocardial bridging and described the location of each according to the American Heart Association classification system. Association of bridging with factors influencing image quality (body mass index and heart rate) was analyzed. Results: Of 152 eligible participants, 49 (32%) showed myocardial bridging. The mid-left anterior descending coronary artery (segment 7) was the most common location accounting for 69% of positive cases. Body mass index and heart rate did not affect detection rates. Conclusion: Electrocardiogram-gated 64-slice multidetector computed tomography is a feasible, noninvasive method of detecting myocardial bridging which may offer higher sensitivity than catheter angiography for this diagnosis.
Closing the gap: towards a process model of post‐merger knowledge sharing

Abstract. We develop a process model of post‐merger knowledge sharing based on distributed cognition, a systems perspective and path dependence. The framework conceptualizes knowledge sharing by layers of management choice and employee appropriation of knowledge resources seen as knowledge as content and knowledge as connection. We use the framework to study a merger of two polymer companies. The study reveals that mergers represent a discontinuity in knowledge sharing. Yet, chosen strategies often mirror the learned knowledge‐sharing practices of one of the merged companies and match poorly with the post‐merger knowledge‐sharing needs. Five factors emerged contribute to this knowledge gap: (a) the nature of the merger; (b) a lack of shared context; (c) the incompatibility of existing knowledge systems; (d) the tacit dimension of knowledge; and (e) time pressures of the merger. Our study shows that, employees enacted knowledge new sharing practices that differed significantly from the official strategy to close to the post‐merger knowledge gap.
Effects of optic nerve injury, glaucoma, and neuroprotection on the survival, structure, and function of ganglion cells in the mammalian retina

Glaucoma is an optic neuropathy that originates with pressure‐induced damage to the optic nerve. This results in the retrograde degeneration of ganglion cells in the retina, and a progressive loss of vision. Over the past several years, a number of studies have described the structural and functional changes that characterize ganglion cell degeneration in the glaucomatous eye, and following optic nerve injury. In addition, a variety of different strategies for providing neuroprotection to the injured retina have been proposed. Many of these are based on the use of brain‐derived neurotrophic factor (BDNF), a particularly potent neuroprotectant in the mammalian eye and the basis of our research in this area. Of particular importance is the fact that BDNF not only promotes ganglion cell survival following damage to the optic nerve, but also helps to preserve the structural integrity of the surviving neurons, which in turn results in enhanced visual function. The studies presented here describe these attributes, and serve as the foundation for ongoing work that suggests a need to think beyond the eye in the development of future treatment strategies.
Frequency of Mild Traumatic Brain Injury in Iraq and Afghanistan: Are We Measuring Incidence or Prevalence?

Objective:Rates of mild traumatic brain injury (mTBI) differ considerably between US and UK forces, despite similar methodology and similar exposure risks. We assessed, in the UK forces, if the differences in rates based on last deployment can be explained by differences in deployment length, given that US forces deploy for approximately twice as long as UK forces. Participants:A total of 3763 personnel deployed to Iraq or Afghanistan who completed a questionnaire between 2007 and 2009. Main Outcome Measures:Mild traumatic brain injury in the last deployment contrasted to current posttraumatic stress disorder, psychological distress (General Health Questionnaire-12), multiple physical symptoms, and alcohol misuse. Results:In the Army and Royal Marines, there was an association between length of deployment (per month) and mTBI (odds ratio: 1.31, 95% confidence interval: 1.13–1.51), which remained significant after adjustment for confounders (odds ratio: 1.25, 95% confidence interval: 1.08–1.45). No other outcome was associated with length of deployment. Results based on the total sample were similar to those in the Royal Marine and Army sample, except for adjusted multiple physical symptoms. Conclusions:Comparisons of mTBI rates should take account of length of deployment when based on last deployment. Doing so reduces but does not eliminate the differences between UK and US forces.
NfuA, a New Factor Required for Maturing Fe/S Proteins in Escherichia coli under Oxidative Stress and Iron Starvation Conditions*

Iron/sulfur (Fe/S) proteins are central to the functioning of cells in both prokaryotes and eukaryotes. Here, we show that the yhgI gene, which we renamed nfuA, encodes a two-domain protein that is required for Fe/S biogenesis in Escherichia coli. The N-terminal domain resembles the so-called Fe/S A-type scaffold but, curiously, has lost the functionally important Cys residues. The C-terminal domain shares sequence identity with Nfu proteins. Mössbauer and UV-visible spectroscopic analyses revealed that, upon reconstitution, NfuA binds a [4Fe-4S] cluster. Moreover, NfuA can transfer this cluster to apo-aconitase. Mutagenesis studies indicated that the N- and C-terminal domains are important for NfuA function in vivo. Similarly, the functional importance of Cys residues present in the Nfu-like domain was demonstrated in vivo by introducing Cys→Ser mutations. In vivo investigations revealed that the nfuA gene is important for E. coli to sustain oxidative stress and iron starvation. Also, combining nfuA with either isc or suf mutations led to additive phenotypic deficiencies, indicating that NfuA is a bona fide new player in Isc- and Suf-dependent Fe/S biogenesis pathways. Taken together, these data demonstrate that NfuA intervenes in the maturation of apoproteins in E. coli, allowing them to acquire Fe/S clusters. By taking into account results from numerous previous transcriptomic studies that had suggested a link between NfuA and protein misfolding, we discuss the possibility that NfuA could act as a scaffold/chaperone for damaged Fe/S proteins.
Lifestyle Practices and Obesity in Nepalese Youth: A Cross-sectional Study

Introduction Understanding the lifestyle factors associated with obesity is critical to create a successful intervention that would prevent or reduce the obesity beforehand. However, these factors have not been assessed among Nepalese youths thus far. This study aims to determine the prevalence of obesity and to explore the potential lifestyle risk factors in young university students of Nepal. Methods We included in the study 384 young students aged between 17 and 24 years, pursuing medicine at Tribhuvan University, Institute of Medicine, in this cross-sectional study. A self-administered questionnaire to collect information about age, sex, smoking, alcohol consumption, meat consumption, fast-food consumption, and sedentary lifestyle was employed. Anthropometric measurements were taken to calculate body mass index (BMI) and waist-to-hip ratio (WHR). Results This study revealed that the current, episodic heavy alcohol consumers, current cigarette smokers, and individuals with a sedentary lifestyle had a statistically significant higher BMI and WHR as compared to age and gender-matched healthy subjects. Meat consumers as well had a statistically significant higher BMI. However, there has been no statistically significant difference in BMI and WHR in those who consume fast food from those who don’t. Conclusion Our study shows a high prevalence of obesity among young university students of Nepal, making it necessary to develop effective preventive measures to reduce their exposure to the risk factors associated with obesity. Early interventions to encourage lifestyle changes can be a worthwhile and effective strategy to prevent and/or reduce the risks for the development of cardiovascular diseases (CVD) and other comorbidities.
Adhesion molecules from the diatom Phaeodactylum tricornutum (Bacillariophyceae): genomic identification by amino‐acid profiling and in vivo analysis

Cell adhesion molecules (CAMs) are important in prokaryotes and eukaryotes for cell–cell and cell–substratum interactions. The characteristics of adhesive proteins in the model diatom Phaeodactylum tricornutum were investigated by bioinformatic analysis and in vivo characterization. Bioinformatic analysis of the protein coding potential of the P. tricornutum genome used an amino‐acid profile that we developed as a new system to identify uncharacterized or novel CAMs. Putative diatom CAMs were identified and seven were characterized in vivo, by generation of transgenic diatom lines overexpressing genes encoding C‐terminal yellow fluorescent protein (YFP) fusion proteins. Three of these selected genes encode proteins with weak similarity to characterized proteins, a c‐type lectin and two fasciclins, whereas the others are novel. The resultant cell lines were investigated for alterations in their adhesive ability. Whole cell‐substratum adhesion strength was measured in a fully turbulent flow chamber, while atomic force microscopy was used to quantify the relative frequency of adhesion, as well as the length and strength of single molecules in the secreted mucilage. Finally, quartz crystal microbalance analysis characterized the visco‐elastic properties and interaction of the mucilage–substratum interface. These combined studies revealed a range of phenotypes affecting adhesion, and led to the identification of candidate proteins involved in diatom adhesion. In summary, our study has for the first time combined bioinformatics and molecular physiological studies to provide new insights into diatom adhesive molecules.