Miracle-dz/UniFAR-FTUs huggingface dataset:
Nonmedical prescription stimulant users experience subjective but not objective impairments in attention and impulsivity

BACKGROUND AND OBJECTIVES Nonmedical prescription stimulant use is frequently reported by college students to improve academic performance, yet it is unknown whether users truly experience cognitive impairments that may drive use. This research compared students with at least one report of nonmedical prescription stimulant use and nonusers on both self-report and objective measures of inattention and impulsivity. METHODS Two studies examined inattention (N = 155) and impulsivity (N = 115) among college students. Participants completed self-report questionnaires and cognitive tests, including Digit Span, the Paced Auditory Serial Addition Test, and a Continuous Performance Test to assess inattention, and the Balloon Analogue Risk Task and the Stop Signal Task to assess risk-taking and impulsivity. RESULTS Self-reports of inattention and impulsive symptoms were significantly higher among users, controlling for gender, GPA, self-reported ADHD, alcohol use, and drug use; however, no objective differences were found. DISCUSSION AND CONCLUSIONS Nonmedical prescription stimulant users may engage in use to overcome perceived deficits in cognitive abilities despite lack of objective evidence. SCIENTIFIC SIGNIFICANCE Understanding discrepancies in objective performance and subjective reports may aid in the development of effective interventions for nonmedical prescription stimulant use. (Am J Addict 2018;27:238-244).
Feeling Loved and Integrated or Lonely and Rejected in Everyday Life: The Role of Age and Social Motivation

Social approach and social avoidance goals (i.e., approach of positive and avoidance of negative outcomes in social situations) are important predictors of the feeling of being socially integrated or isolated. However, little is known about the development of these goals across adulthood. In a large diary study with N = 744 young (18–39 years), middle-aged (40–59 years), and older adults (60–83 years), we tested the hypothesis that the adaptiveness of social goals changes across adulthood: Social approach goals were hypothesized to be adaptive during young adulthood when adult social relationships are to be established. In contrast, social avoidance goals were hypothesized to become more adaptive with age as people are increasingly motivated to avoid interpersonal tension. Our findings support these hypotheses: Social approach goals were positively and social avoidance goals negatively associated with younger but not with middle-aged and older adults’ daily social well-being. These results were robust across different situations (positive, negative) and different types of relationships (close, peripheral). The study highlights the changing role of social approach and avoidance goals for daily social well-being across adulthood.
Crafting memorable VR experiences using experiential fidelity

Much of Virtual Reality (VR) is about creating virtual worlds that are believable. But though the visual and audio experiences we provide today technically approach the limits of human sensory systems, there is still something lacking; something beyond sensory fidelity hinders us from fully buying into the worlds we experience through VR technology. We introduce the notion of Experiential Fidelity, which is an attempt to create a deeper sense of presence by carefully designing the user experience. We suggest to guide the user's frame of mind in a way that their expectations, attitude, and attention are aligned with the actual VR experience, and that the user's own imagination is stimulated to complete the experience. We propose to do this by structuring the time prior to exposure to increase anticipation, expectation, and the like.
Physical determinants of bipolar mitotic spindle assembly and stability in fission yeast

A physical model that exhibits de novo bipolar spindle assembly is used to study the mechanisms of spindle bipolarity. Mitotic spindles use an elegant bipolar architecture to segregate duplicated chromosomes with high fidelity. Bipolar spindles form from a monopolar initial condition; this is the most fundamental construction problem that the spindle must solve. Microtubules, motors, and cross-linkers are important for bipolarity, but the mechanisms necessary and sufficient for spindle assembly remain unknown. We describe a physical model that exhibits de novo bipolar spindle formation. We began with physical properties of fission-yeast spindle pole body size and microtubule number, kinesin-5 motors, kinesin-14 motors, and passive cross-linkers. Our model results agree quantitatively with our experiments in fission yeast, thereby establishing a minimal system with which to interrogate collective self-assembly. By varying the features of our model, we identify a set of functions essential for the generation and stability of spindle bipolarity. When kinesin-5 motors are present, their bidirectionality is essential, but spindles can form in the presence of passive cross-linkers alone. We also identify characteristic failed states of spindle assembly—the persistent monopole, X spindle, separated asters, and short spindle, which are avoided by the creation and maintenance of antiparallel microtubule overlaps. Our model can guide the identification of new, multifaceted strategies to induce mitotic catastrophes; these would constitute novel strategies for cancer chemotherapy.
Post-impact adaptive compliance for humanoid falls using predictive control of a reduced model

We consider control of a humanoid robot in active compliance just after the impact consecutive to a fall. The goal of this post-impact braking is to absorb undesired linear momentum accumulated during the fall, using a limited supply of time and actuation power. The gist of our method is an optimal distribution of undesired momentum between the robot's hand and foot contact points, followed by the parallel resolution of Linear Model Predictive Control (LMPC) at each contact. This distribution is made possible thanks to torque-limited friction polytopes, an extension of friction cones that takes actuation limits into account. Individual LMPC results are finally combined back into a feasible CoM trajectory sent to the robot's whole-body controller. We validate the solution in full-body dynamics simulation of an HRP-4 humanoid falling on a wall.
High Intensity Exercise Metabolism and Muscle Function: Implications for Performance

Copyright: © 2016 Baker JS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. *Corresponding author: Julien S Baker, Applied Physiology Research Laboratory, Institute of Clinical Exercise and Health Science, School of Science and Sport,University of the West of Scotland Hamilton, Lanarkshire, Scotland, UK, Tel: 01698 283100; Ext: 8271; Fax: 01698 894404; E-mail: jsbaker@uws.ac. uk
Effects of radial force and tip path overlap on the ring debarking efficiency of frozen balsam fir logs

This study investigated the effects of the static radial force applied by ring debarker tips to frozen balsam fir logs, and tip path overlap on debarking quality. The radial force is applied by a hydraulic cylinder acting on a lever that forces a tip attached to a tool arm to remove the bark from the log. Each pressure system is set into a rotating ring that peels the log while it is fed through the debarker. The experiment consisted of debarking balsam fir logs using three levels of static radial force, each with two values of overlap between the tip paths. Debarking quality was evaluated by three parameters: the wood fiber loss volume, the percentage of wood in bark residues, and the percentage of bark remaining on log surfaces. Thirty logs of 150-mm diameter at the small end were debarked under frozen wood temperatures (winter) for each cutting condition. The results showed a significant effect of the static radial force on all quality indicators and a significant effect of tip path overlap on the bark remaining on logs. The wood loss volume and the amount of wood in bark residues decreased as radial forces and tip overlap decreased, but more bark remained on the log surfaces. Finally, soaking the logs in warm water for 20 minutes at 8°C was sufficient to substantially improve debarking performance. These results give useful information to estimate the changes in debarking quality that can occur within the range of radial pressures and overlaps covered by the study.
Impaired osmoregulatory responses in rats with area postrema lesions.

Area postrema lesions (APX) in adult male rats produced a robust spontaneous intake of 0.5 M NaCl, as reported previously. The largest NaCl intakes (up to 108 ml/day) were observed when there was little incidental damage in the medial subnucleus of the nucleus of the solitary tract adjacent to the caudal and middle portions of the area postrema. Rats with discrete APX also drank substantial amounts of 0.5 M NaCl when access to saline was restricted to 7 h/day (up to 30 ml in 1 h, 48 ml in 7 h). Such large NaCl intakes stimulated considerable water ingestion and renal sodium excretion, but together these responses usually were insufficient for osmoregulation during the 7-h test period. After systemic administration of hypertonic NaCl solution, rats with APX excreted less Na+ in urine and secreted less vasopressin and oxytocin than control rats did. The prominent salt appetite, insufficient thirst and natriuresis in response to an ingested NaCl load, and blunted natriuresis and neurohypophysial hormone secretion in response to an injected NaCl load, all indicate that osmoregulatory responses are impaired in rats after APX.
Influence of Grapevine Cultivar on the Second Generations of Lobesia botrana and Eupoecilia ambiguella

Grapevine cultivar can affect susceptibility to Lobesia botrana and Eupoecilia ambiguella with important implications on control strategies. A four-year study was carried out in north-eastern Italy on 10 cultivars (Cabernet Sauvignon, Carménère, Chardonnay, Merlot, Refosco dal Peduncolo Rosso, Rhine Riesling, Sauvignon Blanc, Terrano, Tocai Friulano and Verduzzo Friulano) grown in the same vineyard to assess whether the cultivar affects second-generation population levels of the two vine moths and L. botrana larval age composition. The influence of bunch traits measured at the peak of egg hatching on demographic parameters was also evaluated. Over the four years, L. botrana significantly prevailed over E. ambiguella in nine cultivars. Chardonnay and Tocai Friulano were the most infested cultivars and Merlot was the least infested. At the sampling date, the age composition of L. botrana varied with cultivar, with the larvae being significantly older on Chardonnay and younger on Carménère, Merlot and Verduzzo Friulano. Older larval age was significantly associated with higher bunch compactness. Larval infestation was not significantly influenced by either bunch compactness or berry volume, which suggested a more important role for contact and volatile substances mostly originating from the berries. These results allow for the improvement of Integrated Pest Management strategy against vine moths.
Predictors of iron status in well-nourished 4-y-old children.

BACKGROUND Iron status in childhood is influenced by diet. Other factors affecting iron status at that age are unclear. OBJECTIVES The objectives of the study were to evaluate iron status in 4-y-old children, to track that status from infancy to childhood, and to examine the associations of iron status with dietary factors, growth, and heredity. DESIGN This study consisted of a longitudinal follow-up at age 4 y of children (n = 127) from the cohort of a study that began at age 6 mo. Blood samples and anthropometry were assessed in both children and their parents; food records were collected from children only. RESULTS Dietary intake was not significantly correlated with hemoglobin concentrations, whereas the consumption of meat products had a positive effect on serum ferritin concentrations and mean corpuscular volume in boys (P = 0.015 and 0.04, respectively). The prevalences of anemia and iron deficiency were low, affecting 2 (1.8%) and 3 (2.8%) children, respectively; no child had iron deficiency anemia. There was significant within-subject tracking of hemoglobin and mean corpuscular volume from age 6 mo to 4 y. The mother's but not the father's hemoglobin correlated with the child's hemoglobin over time. CONCLUSIONS Food choices had little effect on iron status. Hemoglobin concentrations and mean corpuscular volume were tracked from infancy to childhood. In healthy, well-nourished children with a low prevalence of iron deficiency, the mother's hemoglobin was significantly associated with that of her child, but the underlying mechanism is unclear.
Accumulating short bouts of brisk walking reduces postprandial plasma triacylglycerol concentrations and resting blood pressure in healthy young men.

BACKGROUND Physical activity recommendations promote the accumulation of aerobic activity in bouts of >or=10 min. It is important to determine whether shorter bouts of activity can influence health. OBJECTIVE We compared the effects of accumulating ten 3-min bouts of brisk walking with those of one 30-min bout of brisk walking on postprandial plasma triacylglycerol concentrations and resting blood pressure. DESIGN Fifteen healthy young men completed three 2-d trials >or=1 wk apart in a randomized, repeated-measures design. On day 1, subjects rested (no exercise) or walked briskly in either ten 3-min bouts (30 min rest between each) or one 30-min bout (gross energy expenditure: 1.10 MJ/30 min). On day 2, subjects rested and consumed high-fat test meals for breakfast and lunch. RESULTS On day 2 area under the plasma triacylglycerol concentration over time curve was 16% lower on the accumulated and continuous brisk walking trials than on the control trial (x +/- SEM: 9.98 +/- 0.67 compared with 9.99 +/- 0.76 compared with 11.90 +/- 1.02 mmol x 7h/L, respectively; P = 0.005, one-factor ANOVA). Resting systolic blood pressure was 6-7% lower throughout day 2 on the accumulated and continuous trials than on the control trial (109 +/- 1 compared with 110 +/- 1 compared with 117 +/- 2 mm Hg, respectively; P < 0.0005). CONCLUSION Accumulating 30 min of brisk walking in short (3-min) bouts is equally effective in reducing postprandial lipemia and systolic blood pressure as is one continuous 30-min bout.
Lysine requirement of neonatal piglets receiving total parenteral nutrition as determined by oxidation of the indicator amino acid L-[1-14C]phenylalanine.

The indicator amino acid oxidation technique was adapted for use during total parenteral nutrition. Twenty-one male Yorkshire piglets (3 d of age) fitted with jugular and femoral vein catheters, received total parenteral nutrition for 6 d. Total parenteral nutrition included 15 g amino acids . kg-1.d-1 (1.25 g lysine.kg-1.d-1), lipid + glucose (1.1 MJ.kg-1.d-1), and micronutrients. Piglets were randomly assigned to lysine intakes of 0.40, 0.55, 0.70, 0.85, 1.00, 1.15, or 1.30 g.kg-1.d-1 and received a 4-h primed, constant infusion of L-[1-14C]phenylalanine. Phenylalanine oxidation (% of dose) decreased significantly (P < 0.05) from 18.6% at the lowest lysine intake to 3.0% at a lysine intake of 0.85 g.kg-1.d-1. Further increases in lysine intake had no effect on phenylalanine oxidation. Regression analysis yielded a mean lysine requirement of 0.79 g.kg-1.d-1 and a safe intake (upper 95% confidence limit) of 0.84 g.kg-1.d-1. Changes in the plasma lysine concentration and phenylalanine oxidation rates supported this estimate. The indicator amino acid oxidation technique can now be used to determine amino acid requirements during total parenteral nutrition. This means that the ideal amino acid pattern for neonates receiving total parenteral nutrition can now be defined by a sensitive and minimally invasive measurement of amino acid kinetics.
A Novel Approach to Treating Adolescents with Opioid Use Disorder in Pediatric Primary Care

Background Medication treatment for opioid use disorder is effective, and recommended for adolescents, though very few adolescents with opioid use disorder ever receive medications. Reasons include lack of trained medication prescribers for this age group and difficulty in identifying adolescents with substance use disorders. This manuscript examines a novel implementation model of identifying and providing treatment for substance use disorders, including opioid use disorder, in a pediatric primary care practice. Methods Patients presenting to a selected primary care pediatrics practice for any reason between March 9, 2017 and July 24, 2017 that were identified by screening, self-report or other clinical information to have a substance use problem were referred to an integrated clinical social worker for treatment. We recorded the number of patients that were referred, number of visits completed and SUD and mental health diagnoses. Results In the first 4 months of this program, 683 patients aged 12–22 completed a health maintenance appointment; 20 were referred for substance use disorder treatment and 13 completed at least one substance use disorder treatment visit with the integrated clinical social worker. The mean number of visits completed was 5.3. Three patients with opioid use disorders were identified and 2 were induced on buprenorphine. Conclusions Our model for treatment of substance use disorders, including opioid use disorders, was feasible and acceptable in a pediatric primary care practice. Broadly implemented, such a model could substantially increase access to substance use disorder treatment for adolescents and young adults.
Long-term weight losses associated with prescription of higher physical activity goals. Are higher levels of physical activity protective against weight regain?

BACKGROUND High levels of exercise may be necessary for long-term maintenance of weight loss. OBJECTIVE We aimed to determine in a randomized prospective design whether encouraging 2500 kcal physical activity/wk produced greater 30-mo weight losses than did the standard 1000 kcal physical activity/wk prescription. DESIGN Overweight adults (n = 202) were randomly assigned to either 18 mo of standard behavioral treatment (SBT) with an exercise goal of 1000 kcal/wk or a high physical activity (HPA) treatment with a goal of 2500 kcal/wk. The HPA treatment included all procedures in the SBT plus encouragement to recruit 1-3 exercise partners and small-group counseling with an exercise coach. Participants were followed for 30 mo. RESULTS The HPA group achieved significantly greater exercise levels and weight losses than did the SBT group at 12 and 18 mo (P < 0.01). Weight losses did not differ significantly at 30 mo: 0.90 +/- 8.9 and 2.86 +/- 8.6 kg for the SBT and HPA groups, respectively (P = 0.16). At 30 mo, average exercise levels no longer differed significantly between groups (1390 and 1696 kcal/wk, respectively; P > 0.10). Participants sustaining high exercise levels (>2500 kcal/wk) for 30 mo had significantly (P < 0.001) greater 30-mo weight loss than did those exercising less (12 +/- 8.8 and 0.8 +/- 8.1 kg, respectively). CONCLUSIONS Although participants in the HPA group sustained the 2500-kcal activity goal during the 18-mo treatment, activity declined once treatment ended, which resulted in no between-group differences in activity or weight loss at 2.5 y. Participants who reported continuing to engage in high levels of exercise maintained a significantly larger weight loss.
Consumption of fructooligosaccharides does not favorably affect blood glucose and serum lipid concentrations in patients with type 2 diabetes.

BACKGROUND Fructooligosaccharides have been claimed to lower fasting glycemia and serum total cholesterol concentrations, possibly via effects of short-chain fatty acids produced during fermentation. OBJECTIVE We studied the effects of fructooligosaccharides on blood glucose, serum lipids, and serum acetate in 20 patients with type 2 diabetes. DESIGN In a randomized, single-blind, crossover design, patients consumed either glucose as a placebo (4 g/d) or fructooligosaccharides (15 g/d) for 20 d each. Average daily intakes of energy, macronutrients, and dietary fiber were similar with both treatments. RESULTS Compliance, expressed as the proportion of supplements not returned, was near 100% during both treatments. Fructooligosaccharides did not significantly affect fasting concentrations (mmol/L) of serum total cholesterol (95% CI: -0.07, 0.48), HDL cholesterol (-0.04, 0.04), LDL cholesterol (-0.06, 0.34), serum triacylglycerols (-0.21, 0.44), serum free fatty acids (-0.08, 0.04), serum acetate (-0.01, 0.01), or blood glucose (-0.37, 0.40). CONCLUSIONS We conclude that 20 d of dietary supplementation with fructooligosaccharides had no major effect on blood glucose, serum lipids, or serum acetate in patients with type 2 diabetes. This lack of effect was not due to changes in dietary intake, insufficient statistical power, or noncompliance of the patients.
Fourier analysis of fluctuations of oxygen tension and blood flow in R 3230 Ac tumors and muscle in rats

Braun, Rod D. , Jennifer L. Lanzen, and Mark W. Dewhirst. Fourier analysis of fluctuations of oxygen tension and blood flow in R3230Ac tumors and muscle in rats. Am. J. Physiol. 277 (Heart Circ. Physiol. 46): H551–H568, 1999. — Tumor hypoxia is a major barrier to tumor radiation therapy. Typically tumor hypoxia occurs in two forms: chronic and acute. Although the existence of acute hypoxia has long been acknowledged, its temporal characteristics have never been directly measured and documented. In this study tumor PO2, blood flow (BF), and arterial blood pressure (BP) were measured simultaneously in nine Fischer 344 rats bearing R3230Ac rat mammary adenocarcinomas in the subcutis of the left hindleg. We measured PO2 at a single location for 36–125 min using recessed-tip oxygen microelectrodes. Simultaneously, we measured tumor BF at two sites within the tumor using laser-Doppler flowmetry (LDF). Similar recordings were made in the quadriceps muscle of seven non-tumorbearing rats. The PO2, tumor BF, and BP records were subjected to Fourier analysis. PO2 and BF showed lowfrequency fluctuations (,2 cycles/min) in both tumor and muscle, but the magnitude of the changes in tumor was greater. Tumor BF showed more activity at low frequencies than muscle BF, and the magnitude tended to be greater. No strong correlations were found between PO2 and BF power spectra for either tumor or muscle or between the frequency patterns of BP and tumor PO2 spectra. These results quantitatively demonstrate, for the first time, that BF and PO2 fluctuate at very low frequencies in tumors. In addition to having biological significance for tumor therapy, these fluctuations may have the potential to alter tumor cell behavior via induction of hypoxia reoxygenation injury and/or altered gene expression.