Miracle-dz/UniFAR-FTUs huggingface dataset:
A Search Log Analysis of a Portuguese Web Search Engine

We present a characterization of the information-seeking be- havior of the users of a Portuguese web search engine, based on the analysis of its logs. We obtained detailed statistics about the users' ses- sions, queries, terms and searched topics over a period of two years. The results show that the users prefer fast and short sessions, composed of short queries and few clicks. The trend is towards a reduction of the number of interactions with the web search engine. We also discuss the specificities and interests of the Portuguese users and their implications on the development of better adapted web search engines.
Keratoacanthoma of the Lip

AbstractThe PI3K-PTEN-mTOR is one of the most important pathways involved in cancer development and progression; however, its role in keratoacanthoma (KA) is poorly understood. In this study, we investigated the activation of key proteins in the PI3K-mTOR pathway in lip KA.We analyzed the activation of the PI3K-PTEN-mTOR pathway using human tumor samples stained for well-established protein markers in this pathway, including pS6 and pAKT phosphoproteins. We assessed proliferation using Ki-67 and performed additional morphological and immunohistochemical analysis using anti-PTEN and anti-p16 antibodies.We found that the majority of KA labeled to pS6 and not pAKT. PTEN expression was inversely correlated with Ki-67 expression. In addition to PTEN expression, KA cells were positive for p16Ink4 senescence marker.PI3K-PTEN-mTOR pathway is activated in lip KA, leading to downstream activation of mTORC1, but not mTORC2. This pathway plays an important role in KA progression by promoting proliferation and activation of oncogenic-induced senescence.
Community Structure and Metacommunity Dynamics of Aquatic Invertebrates: a Test of the Neutral Theory

We used a metacommunity of 49 discrete communities of aquatic invertebrates to analyze the dynamical relationship between community and metacommunity species distributions as a test of the neutral theory of biodiversity and biogeography. At the community scale, observed variation in species richness and relative abundance was greater than predicted by neutral models, and revealed important differences among species in competitive ability and tolerance for predation. At the metacommunity scale, species with metacommunity proportions of less than 0.01% (38% of the observed metacommunity) were consistently more abundant than predicted by models. Our results are at variance with the neutral theory, and suggest that the use of an identical survival probability for all species in neutral models misrepresents substantial aspects of community assembly. Nevertheless, building and testing neutral models can provide valuable insights into the processes that determine species distributions.
Trajectories of anxiety in a population sample of children: Clarifying the role of children's behavioral characteristics and maternal parenting

Abstract This study pursued three goals. The first goal was to explore children's trajectories of anxiety from age 6 to 12 using a representative community sample. The second goal was to assess the link between certain behavioral characteristics assessed in kindergarten (i.e., inattention, hyperactivity, aggressiveness, and low prosociality) and these trajectories. The third goal was to determine whether certain aspects of maternal parenting (i.e., warmth and discipline) could moderate the association between these characteristics and the trajectories of anxiety. A population sample of 2,000 children (1,001 boys, 999 girls) participated in this longitudinal study. Developmental trajectory analyses allowed us to identify four trajectory groups: low, low-increasing, high-declining, and high anxiety groups. Moreover, multinomial logistic regressions revealed a profile of children at risk of developing high anxiety symptoms (i.e., high group), characterized by sociofamily adversity, inattention, and low prosociality in the classroom. Hyperactivity was also found in this profile, but only for children exposed to a mother who showed little affective warmth. Finally, mothers' high level of discipline increased the odds of belonging to the high anxiety group. The results are discussed in relation to studies examining the association among anxiety, behavioral characteristics, and parenting during childhood.
Leaching characteristics of selected South African fly ashes: Effect of pH on the release of major and trace species

Fly ash samples from two South African coal-fired power stations were subjected to different leaching tests under alkaline and acidic conditions in an attempt to assess the effect of pH on the leachability of species from the fly ashes and also assess the potential impact of the fly ashes disposal on groundwater and the receiving environment. To achieve this, German Standard leaching (DIN-S4) and Acid Neutralization Capacity (ANC) tests were employed. Mineralogical characterization of the fresh fly ashes revealed mullite and quartz as the major mineral phases with minor peaks of CaO and calcite. Chemical characterization by X-ray fluorescence (XRF) spectrometry revealed that the two fly ashes are similar, and consist of SiO2, Al2O3, Fe2O3 and CaO as the main components with Cr, Co, Ni, Cu, Zn, V and Pb as minor components. Ca, Mg, Na, K and SO4 were significantly leached into solution under the two leaching conditions with the total amounts in ANC leachates higher than that of DIN-S4. This indicates that a large fraction of the soluble salts in unweathered fly ash are easily leached. These species represents the fraction that can be flushed off initially from the surface of ash particles on contacting the ash with water. Al and Si were only observed in the leachates of the ANC test. Results obtained from the total acid-digestion and DIN-S4 leaching test indicated some toxic elements in the fly ashes are not easily solubilized. The amounts of toxic trace elements such as As, Se, Cd, Cr and Pb leached out of the fly ashes when in contact with de-mineralized water (DIN-S4 test) were low and below the Target Water Quality Range (TWQR) of South Africa. This is explained by their low concentrations in the fly ashes and their solubility dependence on the pH of the leaching solution. However the amounts of some minor elements such as B, Mn, Fe, As and Se leached out at lower pH ranging between 10 to 4 (ANC test) were slightly higher than the TWQR, an indication that the pH of the leaching solution plays a significant role on the leaching of species in fly ash. The high concentrations of the toxic elements released from the fly ashes at lower pH gives an indication that the disposal of the fly ash could have adverse effects on the receiving environment if the pH of the solution contacting the ashes is not properly monitored. The study indicated that on contact with water in a disposal scenario fly ash will release high amounts of soluble species.
Evaluation tools through user participation techniques: Features, limitations, and new perspectives

The evaluation of user interfaces is a rich theme in terms of concepts, approaches, and tools. The related tools are numerous that they are mainly classified into two categories. The first one includes the tools based on expert analysis techniques. These tools require a designer and/or an evaluator during the evaluation process. The second category issued tools require user participation in the evaluation process. In this article, we focus on the second category related tools. These tools are so numerous that we estimate that it is interesting to study them. They are based on user action data capture, study, and analysis in order to evaluate user interfaces. This paper aims at drawing up the features, the limitations, and the perspectives of existing user interface evaluation tools based on user participation techniques.
Assessing the FY 1989 change in Medicare PPS outlier policy

In fiscal year (FY) 1989, Medicare changed its rules for paying for extremely long or expensive hospital stays called “outliers. ” We compared outlier payments in FYs 1989 and 1988, after adjusting for other simultaneous policy changes. We found that the new policy succeeded in targeting more outlier payments to the most expensive cases and to the hospitals suffering larger prospective payment system (PPS) losses and in reducing hospital financial risk. Using time-series analyses, we show that the policy change had no measurable effect on the timing of discharges or on the concentration of expensive cases in urban government-owned hospitals.
An Extreme Case of a Misaligned Highly Flattened Wind in the Wolf-Rayet Binary CX Cephei

CX Cep (WR 151) is the WR+O binary (WN5+O5 V) with the second shortest period known in our Galaxy. To examine the circumstellar matter distribution and to better constraint the orbital parameters and mass-loss rate of the W-R star, we obtained broadband and multiband (i.e., UBVRI) linear polarization observations of the system. Our analysis of the phase-locked polarimetric modulation confirms the high orbital inclination of the system (i.e., i = 65°). Using the orbital solution of Lewis et al. (1993), we obtain masses of 33.9 and 23.9 M☉ for the O and W-R stars, respectively, which agree with their spectral types. A simple polarimetric model accounting for finite stellar size effects allowed us to derive a mass-loss rate for the W-R star of (0.3-0.5) × 10-5 M☉ yr-1. This result was remarkably independent of the model's input parameters and favors an earlier spectral type for the W-R component (i.e., WN4). Finally, using our multiband observations, we fitted and subtracted from our data the interstellar polarization. The resulting constant intrinsic polarization of 3%-4% is misaligned in relation to the orbital plane (i.e., θCIP = 26° vs. Ω = 75°) and is the highest intrinsic polarization ever observed for a W-R star. This misalignment points toward a rotational (or magnetic) origin for the asymmetry and contradicts the most recent evolutionary models for massive stars (Meynet & Maeder 2003) that predict spherically symmetric winds during the W-R phase (i.e., CIP = 0%).
On Translation Corpora and Translation Support Tools: A Project Report

For more than forty years machine translation has been an active area of research and development. Several variants of MT systems have been proposed e.g., interactive systems, batch-mode systems requiring a large amount of human post-editing and systems that generate text in several languages from a common structured set of data rather than a source text. Although there are some successful systems and several products on the market, it is still the case that most translators and translation companies prefer not to use MT-systems. In fact, it has been estimated “that the current share of anything that could be called MT, pure or mixed, is well below 1% of the total translation market” (Isabelle et al, 1993).
Not all sugars are created equal: some mask aversive tastes better than others in an herbivorous insect

SUMMARY Manduca sexta caterpillars are unusual because they exhibit strong peripheral gustatory responses to sugars, but nevertheless fail to show immediate appetitive responses to them. We hypothesized that the primary function of the peripheral gustatory response to sugars is to mask the taste of noxious compounds, which abound in host plants of M. sexta. We compared 10 s biting responses to water with those to mixtures of a noxious compound [caffeine (Caf) or aristolochic acid (AA)] and various combinations of sugars [i.e. sucrose (Suc), glucose (Glu), inositol (Ino), Suc+Glu, Suc+Ino or Glu+Ino]. The biting assays indicated that the aversive taste of AA was completely masked by Suc+Ino, and partially masked by Suc+Glu, Glu+Ino and Suc, whereas that of Caf was completely masked by Suc+Ino and Suc+Glu, and partially masked by Glu+Ino, Suc and Ino. To examine the contribution of the peripheral taste system to the masking phenomenon, we recorded responses of the maxillary gustatory sensilla to each stimulus mixture. The sugars differed greatly in their capacity to suppress peripheral gustatory responses to AA and Caf: Suc+Ino and Suc+Glu produced the greatest suppression, and Glu and Ino the least. Further, the extent to which each sugar stimulus suppressed the peripheral gustatory responses to AA reliably predicted the extent to which it masked the taste of AA in biting assays; no such predictive relationship was observed for the sugar/Caf mixtures. We conclude that some, but not all, sugars act on both peripheral and central elements of the gustatory system to mask the taste of noxious compounds.
The role of KIR2DL3/HLA-C*0802 in Brazilian patients with rheumatoid vasculitis

OBJECTIVES: Rheumatoid arthritis is a polygenically controlled systemic autoimmune disease. Rheumatoid vasculitis is an important extra-articular phenotype of rheumatoid arthritis that can result in deep cutaneous ulcers. The objective of this study was to establish a correlation between the frequency of major histocompatibility complex class I/II alleles and killer immunoglobulin-like receptor genotypes in patients with cutaneous rheumatoid vasculitis. METHODS: Using the Scott & Bacon 1984 criteria to diagnose rheumatoid vasculitis and after excluding any other causes such as diabetes, atherosclerosis, adverse drug reactions, infection, and smoking, patients who met the criteria were selected. All of the selected rheumatoid vasculitis patients presented deep cutaneous ulcers. Identification of the major histocompatibility complex class I/II and killer immunoglobulin-like receptor genotypes was performed by polymerase chain reaction assays of samples collected from the 23 rheumatoid vasculitis patients as well as from 80 controls (40 non-rheumatoid vasculitis RA control patients and 40 healthy volunteers). RESULTS: An association between the presence of the HLA-DRB1*1402 and HLA-DRB1*0101 alleles and cutaneous lesions in rheumatoid vasculitis patients and a correlation between the inhibitor KIR2DL3 and the HLA-C*0802 ligand in rheumatoid vasculitis patients were found. CONCLUSION: An association was found between the presence of the HLA-DRB1*1402 and HLA-DRB1*0101 alleles and the development of cutaneous lesions in rheumatoid vasculitis patients. Additionally, the HLA-C*0802 ligand protects these individuals from developing cutaneous lesions.
Serum levels of C-reactive protein in adolescents with periodontitis.

BACKGROUND The results of several cross-sectional studies suggested a relationship between periodontitis and higher serum levels of C-reactive protein (CRP). Most of these studies were restricted to adult study groups with severe periodontal inflammation, and the potential effects of confounding factors were frequently overlooked. METHODS A case-referent study comprised of 87 adolescent cases who presented with clinical attachment loss ≥3 mm recorded in ≥2 of 16 teeth and 73 controls who did not fulfill these criteria was nested in a fully enumerated adolescent population. Venous blood samples were obtained, and CRP levels were quantified, using a high-sensitive bead-based flow cytometric assay. The Mann-Whitney U test was used to assess overall differences between groups. RESULTS The median serum CRP values for cases and controls were 64 ng/ml (interquartile range: 27 to 234 ng/ml) and 55 ng/ml (31 to 183 ng/ml), respectively (P = 0.8). CONCLUSIONS Serum levels of CRP were not significantly higher among subjects with periodontitis than among controls. However, a statistically significant positive association between percentages of sites with bleeding on probing and log-transformed CRP values was observed.
Immunohistochemical demonstration of glutathione S‐transferases in primary human breast carcinomas

The expression of cytosolic glutathione S‐transferase (GST) isoenzymes has been assessed in a series of 74 primary human breast carcinomas using an immunohistochemical method. GST pi was detected in sections from all 74 tumours; it was expressed by non‐epithelial (stromal and inflammatory) cells in 62 tumours (84 per cent), but by tumour epithelium in only 35 (47 per cent). Non‐neoplastic mammary epithelium was uniformly positive for GST pi. Expression of GST alpha and mu was observed in 19 and 42 per cent of the tumours, respectively, and was largely confined to the neoplastic component. Lack of staining of tumour epithelium for GST pi was significantly associated with poorer tumour differentiation (higher grade). There was no association between expression of any of the three isoenzymes and either menopausal status or expression of c‐erbB‐2 oncogene protein product.
Abnormal electrocardiographic findings in athletes: recognising changes suggestive of cardiomyopathy

Cardiomyopathies are a heterogeneous group of heart muscle diseases and collectively are the leading cause of sudden cardiac death (SCD) in young athletes. The 12-lead ECG is utilised as both a screening and diagnostic tool for detecting conditions associated with SCD. Fundamental to the appropriate evaluation of athletes undergoing ECG is an understanding of the ECG findings that may indicate the presence of an underlying pathological cardiac disorder. This article describes ECG findings present in cardiomyopathies afflicting young athletes and outlines appropriate steps for further evaluation of these ECG abnormalities. The ECG findings defined as abnormal in athletes were established by an international consensus panel of experts in sports cardiology and sports medicine.
Children of International Migrants in Europe: Comparative Perspectives

Introduction The EFFNATIS Project Sociological Models of Immigrant Incorporation International Migration to Britain, France and Germany Theoretical Paradigms for the Sociological Analysis of Children of International Migrants Linguistic Incorporation: Patterns of Language Use Structural Incorporation: Education, Training and the Labour Market Political and Religious Incorporation Cultural Incorporation: Lifestyle, Media and Identity Social Incorporation: Friendship and Marriage Socio-Cultural Exceptionalism: Arranged Marriages in Western Europe Conclusions
Reviewing the Assumptions About Men’s Mental Health: An Exploration of the Gender Binary

Many researchers take for granted that men’s mental health can be explained in the same terms as women’s or can be gauged using the same measures. Women tend to have higher rates of internalizing disorders (i.e., depression, anxiety), while men experience more externalizing symptoms (i.e., violence, substance abuse). These patterns are often attributed to gender differences in socialization (including the acquisition of expectations associated with traditional gender roles), help seeking, coping, and socioeconomic status. However, measurement bias (inadequate survey assessment of men’s experiences) and clinician bias (practitioner’s subconscious tendency to overlook male distress) may lead to underestimates of the prevalence of depression and anxiety among men. Continuing to focus on gender differences in mental health may obscure significant within-gender group differences in men’s symptomatology. In order to better understand men’s lived experiences and their psychological well-being, it is crucial for scholars to focus exclusively on men’s mental health.
The Relationship of Supervisors' Attachment Styles to their Perceptions of Self-Efficacy in Providing Corrective Feedback and to the Working Alliance in Counselor Education

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Improving smoothed particle hydrodynamics with an integral approach to calculating gradients

Context. The smoothed particle hydrodynamics (SPH) technique is a well-known numerical method that has been applied to simulate the evolution of a wide variety of systems. Modern astrophysical applications of the method rely on the Lagrangian formulation of fluid Euler equations, which is fully conservative. A different scheme, based on a matrix approach to the SPH equations is currently being used in computational fluid dynamics. These matrix formulations achieve better interpolations of the physical magnitudes but they are, in general, not fully conservative. The matrix approach to the Euler equations has never been used in astrophysics. Aims. We develop and test a fully conservative SPH scheme based on a tensor formulation that can be applied to simulate astrophysical systems. Methods. In the proposed scheme, derivatives are calculated from an integral expression that leads to a tensor (instead of a vectorial) estimation of gradients and reduces to the standard formulation in the continuum limit. The new formulation improves the interpolation of physical magnitudes, leading to a set of conservative equations that resembles those of standard SPH. The resulting scheme is verified using a variety of well-known tests, all of them simulated in two dimensions. We also discuss an application of the proposed tensor method to astrophysics by simulating the stability of a Sun-like polytrope calculated in three dimensions. Results. The proposed scheme is able to improve the results of standard SPH in the two-dimensional tests, especially in the simulation of subsonic hydrodynamic instabilities. Our results for the stability of the Sun-like polytrope suggest that the new method can be used in astrophysics to carry out three-dimensional calculations with a computational cost that is only slightly higher (i.e. ≤50% for a serial code) than that of a standard SPH formulation. Conclusions. A formalism based on a matrix approach to Euler SPH equations was developed and checked. The new scheme is more accurate because of the re-normalization imposed on the interpolations, which is fully conservative and probably less prone to undergo the tensile instability. The analysis of several test cases suggest that the method may improve the simulation of both subsonic and supersonic systems. An application of the tensor method to astrophysics is, for the first time, successfully carried out. These encouraging results indicates that more work should be invested in the applications of matrix SPH formulations to astrophysics.
Adenosinetriphosphatase Activity in the Cell Membranes of Kidney Tubule Cells

This cytochemical study demonstrates high levels of apparent ATPase activity in the infolded cell membranes of the proximal tubules (dog, rat, human, mouse, monkey, and opossum) and ascending loops of Henle (dog, rat, human and, to a variable degree, mouse). Electron microscopy has shown (see Rhodin (1)) that these membranes separate adjacent cells where they interlock with one another by multiple cytoplasmic lamellae containing oriented mitochondria. The significance of the high ATPase activity is considered in relation to possible movements of the membranes and to "active transport" believed to occur there. In the rat, enzyme activity in the proximal tubule membranes does not survive formol-calcium fixation, and it is therefore necessary to use unfixed sections for its demonstration. However, in edematous rats with experimental nephrosis (induced by the injection of aminonucleoside or with antikidney serum) marked ATPase activity is exhibited in these membranes even after formol-calcium fixation. When proximal tubule or Henle loop cells of the dog acquire an altered metabolism, as indicated by accumulated lipide spheres or by "droplets," the infolded ATPase-rich membranes are no longer demonstrable.