Miracle-dz/UniFAR-FTUs huggingface dataset:
Vastus lateralis exhibits non‐homogenous adaptation to resistance training

Introduction: Variations in transverse point of measure on the vastus lateralis (VL) may significantly affect the relationship between structure and function. The purpose of this study was to compare changes in muscle architecture at 2 commonly used points of measure (VL0 and VL5). Methods: Maximal strength (1‐repetition maximum [1RM] barbell squat) and muscle architecture were assessed PRE and POST 15 weeks of periodized resistance training. VL0 was 50% of the straight line distance between the greater trochanter and lateral epicondyle of the femur. VL5 was 5cm medial to VL0. Results: Increases in 1RM strength (3.7 ± 2.4 kg; P = 0.004) were observed. Changes in muscle thickness (MT) at VL5 were significantly greater than at VL0 (P = 0.006). Changes in strength correlated with changes in muscle architecture at VL0 only (MT: r = 0.561; fascicle length: r = 0.503). Conclusions: Changes in muscle architecture appear to occur in a non‐homogeneous manner. Muscle Nerve 50: 785–793, 2014
Upper mantle structure of eastern Asia from multimode surface waveform tomography

[1] We present a new three-dimensional Sv wave speed and azimuthal anisotropy model for the upper mantle of eastern Asia constrained by the analysis of more than 17,000 vertical component multimode Rayleigh wave seismograms. This data set allows us to build an upper mantle model for Asia with a horizontal resolution of a few hundred kilometers extending to ∼400 km depth. At 75–100 km depth, there is approximately ±9% wave speed perturbation from the “smoothed PREM” reference model used in our analysis, and the pattern of azimuthal anisotropy is complex. Both the amplitude of the Sv wave speed heterogeneity and the complexity and amplitude of the azimuthal anisotropy decrease with depth. Above ∼200 km depth the upper mantle structure of the model correlates with surface geology and tectonics; below ∼200 km depth the structures primarily reflect the advection of material in the upper mantle. Since shear wave speed is principally controlled by temperature rather than by composition, Vs(z) can be used to calculate the temperature T(z), and hence map the lithospheric thickness. We use the relationship of Priestley and McKenzie to produce a contour map of the lithospheric thickness of eastern Asia from the surface wave tomography. This shows an extensive region of thick lithosphere beneath the Siberian Platform and the West Siberian Basin that extends to the European Platform, forming the stable Eurasian craton or core. The eastern portion of the Eurasian craton has controlled the geometry of continental deformation and the distribution of kimberlites in eastern Asia.
Computing Optimal Monitoring Strategy for Detecting Terrorist Plots

In recent years, terrorist organizations (e.g., ISIS or al-Qaeda) are increasingly directing terrorists to launch coordinated attacks in their home countries. One example is the Paris shootings on January 7, 2015.By monitoring potential terrorists, security agencies are able to detect and stop terrorist plots at their planning stage.Although security agencies may have knowledge about potential terrorists (e.g., who they are, how they interact), they usually have limited resources and cannot monitor all terrorists.Moreover, a terrorist planner may strategically choose to arouse terrorists considering the security agency's monitoring strategy. This paper makes five key contributions toward the challenging problem of computing optimal monitoring strategies: 1) A new Stackelberg game model for terrorist plot detection;2) A modified double oracle framework for computing the optimal strategy effectively;3) Complexity results for both defender and attacker oracle problems;4) Novel mixed-integer linear programming (MILP) formulations for best response problems of both players;and 5) Effective approximation algorithms for generating suboptimal responses for both players.Experimental evaluation shows that our approach can obtain a robust enough solution outperforming widely-used centrality based heuristics significantly and scale up to realistic-sized problems.
DNA methylation in the human placenta and fetal growth (Review)

Throughout in utero development, the placenta plays a key role in controlling growth and development. The placenta acts not only as a gatekeeper of nutrient and waste exchange between mother and developing fetus, but also as a regulator of the intrauterine environment. Its functions can be influenced by the environment encountered throughout pregnancy, thereby altering the appropriate genetic programming needed to allow for appropriate fetal growth. Epigenetic alterations related to environmental exposures have been linked to aberrant fetal growth. DNA methylation, which is the best known DNA epigenetic modification, may provide an attractive mechanism linking environmental cues to placental pathology, with consequences for fetal growth and adult life. Alteration of the methylation patterns of genes expressed in the placenta has recently been found to modify gene expression and subsequently impair function of the placenta. Although there is strong evidence to demonstrate that the environment can affect the pattern of DNA methylation of the placenta during fetal development, a direct association between environmental conditions, methylation alterations and gene expression is difficult to confirm. DNA methylation in the placenta has mainly been investigated in the context of imprinted and non-imprinted genes transcription. Several environmental factors have also been assessed in regard to their association with changes to the epigenetic motives of embryonic and extraembryonic tissues and their impact on pregnancy outcome. In this review, we briefly present the available evidence regarding the role of DNA methylation patterns of the placenta on aberrant fetal growth.
Plant growth-promoting rhizobacteria (PGPR): Their potential as antagonists and biocontrol agents

Bacteria that colonize plant roots and promote plant growth are referred to as plant growth-promoting rhizobacteria (PGPR). PGPR are highly diverse and in this review we focus on rhizobacteria as biocontrol agents. Their effects can occur via local antagonism to soil-borne pathogens or by induction of systemic resistance against pathogens throughout the entire plant. Several substances produced by antagonistic rhizobacteria have been related to pathogen control and indirect promotion of growth in many plants, such as siderophores and antibiotics. Induced systemic resistance (ISR) in plants resembles pathogen-induced systemic acquired resistance (SAR) under conditions where the inducing bacteria and the challenging pathogen remain spatially separated. Both types of induced resistance render uninfected plant parts more resistant to pathogens in several plant species. Rhizobacteria induce resistance through the salicylic acid-dependent SAR pathway, or require jasmonic acid and ethylene perception from the plant for ISR. Rhizobacteria belonging to the genera Pseudomonas and Bacillus are well known for their antagonistic effects and their ability to trigger ISR. Resistance-inducing and antagonistic rhizobacteria might be useful in formulating new inoculants with combinations of different mechanisms of action, leading to a more efficient use for biocontrol strategies to improve cropping systems.
Purification and Characterization of Plantaricin ZJ5, a New Bacteriocin Produced by Lactobacillus plantarum ZJ5

The aim of this study is to investigate the antimicrobial potential of Lactobacillus plantarum ZJ5, a strain isolated from fermented mustard with a broad range of inhibitory activity against both Gram-positive and Gram-negative bacteria. Here we present the peptide plantaricin ZJ5 (PZJ5), which is an extreme pH and heat-stable. However, it can be digested by pepsin and proteinase K. This peptide has strong activity against Staphylococcus aureus. PZJ5 has been purified using a multi-step process, including ammonium sulfate precipitation, cation-exchange chromatography, hydrophobic interactions and reverse-phase chromatography. The molecular mass of the peptide was found to be 2572.9 Da using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). The primary structure of this peptide was determined using amino acid sequencing and DNA sequencing, and these analyses revealed that the DNA sequence translated as a 44-residue precursor containing a 22-amino-acid N-terminal extension that was of the double-glycine type. The bacteriocin sequence exhibited no homology with known bacteriocins when compared with those available in the database, indicating that it was a new class IId bacteriocin. PZJ5 from a food-borne strain may be useful as a promising probiotic candidate.
Automatic Content-Aware Projection for 360° Videos

To watch 360° videos on normal 2D displays, we need to project the selected part of the 360° image onto the 2D display plane. In this paper, we propose a fully-automated framework for generating content-aware 2D normal-view perspective videos from 360° videos. Especially, we focus on the projection step preserving important image contents and reducing image distortion. Basically, our projection method is based on Pannini projection model. At first, the salient contents such as linear structures and salient regions in the image are preserved by optimizing the single Panini projection model. Then, the multiple Panini projection models at salient regions are interpolated to suppress image distortion globally. Finally, the temporal consistency for image projection is enforced for producing temporally stable normal-view videos. Our proposed projection method does not require any user-interaction and is much faster than previous content-preserving methods. It can be applied to not only images but also videos taking the temporal consistency of projection into account. Experiments on various 360° videos show the superiority of the proposed projection method quantitatively and qualitatively.
The Effect of Osmotic Shock on Release of Bacterial Proteins and on Active Transport

Osmotic shock is a procedure in which Gram-negative bacteria are treated as follows. First they are suspended in 0.5 M sucrose containing ethylenediaminetetraacetate. After removal of the sucrose by centrifugation, the pellet of cells is rapidly dispersed in cold, very dilute, MgCl2. This causes the selective release of a group of hydrolytic enzymes. In addition, there is selective release of certain binding proteins. So far, binding proteins for D-galactose, L-leucine, and inorganic sulfate have been discovered and purified. The binding proteins form a reversible complex with the substrate but catalyze no chemical change, and no enzymatic activities have been detected. Various lines of evidence suggest that the binding proteins may play a role in active transport: (a) osmotic shock causes a large drop in transport activity associated with the release of binding protein; (b) transport-negative mutants have been found which lack the corresponding binding protein; (c) the affinity constants for binding and transport are similar; and (d) repression of active transport of leucine was accompanied by loss of binding protein. The binding proteins and hydrolytic enzymes released by shock appear to be located in the cell envelope. Glucose 6-phosphate acts as an inducer for its own transport system when supplied exogenously, but not when generated endogenously from glucose.
Psychological response to cancer and survival

SYNOPSIS The hypothesis is advanced that the psychological stance which patients adopt in response to cancer can, in some cases, influence the course of their disease. This hypothesis is examined in the light of the author's 15-year follow-up study of women with early breast cancer and of other pertinent studies. The available evidence supports the hypothesis in respect of certain earlystage non-metastatic cancers.
Protein aggregates stimulate macropinocytosis facilitating their propagation

ABSTRACT Temporal and spatial patterns of pathological changes such as loss of neurons and presence of pathological protein aggregates are characteristic of neurodegenerative diseases such as Amyotrophic Lateral Sclerosis, Frontotemporal Dementia, Alzheimer's disease and Parkinson's disease. These patterns are consistent with the propagation of protein misfolding and aggregation reminiscent of the prion diseases. There is a surge of evidence that suggests that large protein aggregates of a range of proteins are able to enter cells via macropinocytosis. Our recent work suggests that this process is activated by the binding of aggregates to the neuron cell surface. The current review considers the potential role of cell surface receptors in the triggering of macropinocytosis by protein aggregates and the possibility of utilizing macropinocytosis pathways as a therapeutic target.
Cenozoic stratigraphy of the southern Salar de Antofalla region, northwestern Argentina

En la parte sur del Salar de Antofalla (Provincia de Catamarca; noroeste de Argentina) afloran sedimentitas continentales de edad eocena tardio a plio-pleistocena con espesores de hasta 1.600 m. Estan compuestas por materiales aluviales, lacustres, eolicos e intercalaciones de lavas y rocas piroclasticas. Las sedimentitas continentales representan complejos de abanicos aluviales y depositos de playa acumulados bajo condiciones climaticas aridas y semiaridas. Desde el Eoceno Tardio al Mioceno Temprano la sedimentacion se desarrollo en cuencas de antepais desmembradas, mientras que a partir del Mioceno Temprano al Plioceno Tardio-Pleistoceno temprano(? ) la sedimentacion se desarrollo, en su mayoria, dentro de cuencas de retroarco compresionales. Volcanes formaron limites locales de estas cuencas. Sobre la base de diferencias de litofacies y discordancias angulares se distinguieron siete unidades estratigraficas: Formacion Quinoas del Eoceno Tardio a Mioceno Temprano, la cual a su vez, puede ser subdividida en los miembros Campo Negro, Miembro Cadillo y Aguada; la Formacion Potrero Grande del Mioceno Temprano/Medio; Formacion Antofalla la cual puede ser subdividida en los miembros Cajeros y Bordo Blanco; las capas Salina del Mioceno Tardio; Formacion Pozuelos del Mioceno Tardio (Miembro Orilla); Formacion Sijes del Mioceno/Plioceno Temprano (Miembro Uncal Grande) y Formacion Singuel del Plioceno/Pleistoceno temprano (Miembro Agua Escondida). Las formaciones Quinoas, Potrero Grande y Antofalla y las capas Salina constituyen unidades nuevas, en tanto que las otras formaciones son conocidas en la division estratigrafica de la Puna meridional. Los estratos que no tienen conexion lateral con aquellos de sus localidades tipos, y que afloran cerca del Salar Pastos Grandes, se definieron como miembros laterales.
Recalibration of general circulation model output to austral summer rainfall over southern Africa

Empirical techniques are developed to adjust dynamic model forecasts on the seasonal time scale for southern African summer rainfall. The techniques, perfect prognosis and model output statistics (MOS), are utilized to ‘recalibrate’ the CSIRO 9 general circulation model (GCM) large‐scale fields statistically to three equi‐probable rainfall categories for December to February. The recalibration is applied to a GCM experiment where simultaneously observed sea‐surface temperature fields serve as the lower boundary forcing. An optimal canonical correlation analysis model is designed for MOS and perfect prognosis and the 700 hPa geopotential height field is selected as the single predictor field in the two sets of statistical equations that are subsequently used to produce recalibrated rainfall simulations over a 10 year independent test period. MOS produced the higher forecast skill for southern Africa over the independent test period. Copyright © 2003 Royal Meteorological Society
N on-linear evolution of f(R) cosm ologies II:power spectrum

We carry out a suite of cosmological simulations of modified action f(R) models where cosmic acceleration arises from an alteration of gravity instead of dark energy. These models introduce an extra scalar degree of freedom which enhances the force of gravity below the inverse mass or Compton scale of the scalar. The simulations exhibit the so-called chameleon mechanism, necessary for satisfying local constraints on gravity, where this scale depends on environment, in particular, the depth of the local gravitational potential. We find that the chameleon mechanism can substantially suppress the enhancement of power spectrum in the nonlinear regime if the background field value is comparable to or smaller than the depth of the gravitational potentials of typical structures. Nonetheless power spectrum enhancements at intermediate scales remain at a measurable level for models even when the expansion history is indistinguishable from a cosmological constant, cold dark matter model. Simple scaling relations that take the linear power spectrum into a nonlinear spectrum fail to capture the modifications of f(R) due to the change in collapsed structures, the chameleon mechanism, and the time evolution of the modifications.
Patterns of philopatry and longevity contribute to the evolution of post-reproductive lifespan in mammals

While menopause has long been known as a characteristic trait of human reproduction, evidence for post-reproductive lifespan (PRLS) has recently been found in other mammals. Adaptive and non-adaptive hypotheses have been proposed to explain the evolution of PRLS, but formal tests of these are rare. We use a phylogenetic approach to evaluate hypotheses for the evolution of PRLS among mammals. In contrast to theoretical models predicting that PRLS may be promoted by male philopatry (which increases relatedness between a female and her group in old age), we find little evidence that male philopatry led to the evolution of a post-reproductive period. However, the proportion of life spent post-reproductive was related to lifespan and patterns of philopatry, suggesting that the duration of PRLS may be impacted by both non-adaptive and adaptive processes. Finally, the proportion of females experiencing PRLS was higher in species with male philopaty and larger groups, in accordance with adaptive models of PRLS. We suggest that the origin of PRLS primarily follows the non-adaptive ‘mismatch’ scenario, but that patterns of philopatry may subsequently confer adaptive benefits of late-life helping.
An Experimental Study of Wind Abrasion

Rocks were abraded by a sand-laden air-jet in the laboratory to examine the quantitative relationships between wind abrasion and wind velocity, quantity and grain-size of windblown sand particles, and physical properties of the target rocks. The results of 101 runs are expressed by an experimental equation with dimensionless constant, which indicates that the rate of abrasion is directly related to the kinetic energy of the sand projectiles and inversely proportional to the compressive strength of the target rocks. A tentative extension of the experimental equation to field condition leads to an equation for the wind abrasion in fields. An application of the latter equation to the natural settings is preliminarily examined by comparing it with Sharp's (1964) field experiments, and a plausible result is obtained.
Rapid expansion of oceanic anoxia immediately before the end-Permian mass extinction

Periods of oceanic anoxia have had a major influence on the evolutionary history of Earth and are often contemporaneous with mass extinction events. Changes in global (as opposed to local) redox conditions can be potentially evaluated using U system proxies. The intensity and timing of oceanic redox changes associated with the end-Permian extinction horizon (EH) were assessed from variations in 238U/235U (δ238U) and Th/U ratios in a carbonate section at Dawen in southern China. The EH is characterized by shifts toward lower δ238U values (from -0.37‰ to -0.65‰), indicative of an expansion of oceanic anoxia, and higher Th/U ratios (from 0.06 to 0.42), indicative of drawdown of U concentrations in seawater. Using a mass balance model, we estimate that this isotopic shift represents a sixfold increase in the flux of U to anoxic facies, implying a corresponding increase in the extent of oceanic anoxia. The intensification of oceanic anoxia coincided with, or slightly preceded, the EH and persisted for an interval of at least 40,000 to 50,000 y following the EH. These findings challenge previous hypotheses of an extended period of whole-ocean anoxia prior to the end-Permian extinction.
Estimation of Directed Effective Connectivity from fMRI Functional Connectivity Hints at Asymmetries of Cortical Connectome

The brain exhibits complex spatio-temporal patterns of activity. This phenomenon is governed by an interplay between the internal neural dynamics of cortical areas and their connectivity. Uncovering this complex relationship has raised much interest, both for theory and the interpretation of experimental data (e.g., fMRI recordings) using dynamical models. Here we focus on the so-called inverse problem: the inference of network parameters in a cortical model to reproduce empirically observed activity. Although it has received a lot of interest, recovering directed connectivity for large networks has been rather unsuccessful so far. The present study specifically addresses this point for a noise-diffusion network model. We develop a Lyapunov optimization that iteratively tunes the network connectivity in order to reproduce second-order moments of the node activity, or functional connectivity. We show theoretically and numerically that the use of covariances with both zero and non-zero time shifts is the key to infer directed connectivity. The first main theoretical finding is that an accurate estimation of the underlying network connectivity requires that the time shift for covariances is matched with the time constant of the dynamical system. In addition to the network connectivity, we also adjust the intrinsic noise received by each network node. The framework is applied to experimental fMRI data recorded for subjects at rest. Diffusion-weighted MRI data provide an estimate of anatomical connections, which is incorporated to constrain the cortical model. The empirical covariance structure is reproduced faithfully, especially its temporal component (i.e., time-shifted covariances) in addition to the spatial component that is usually the focus of studies. We find that the cortical interactions, referred to as effective connectivity, in the tuned model are not reciprocal. In particular, hubs are either receptors or feeders: they do not exhibit both strong incoming and outgoing connections. Our results sets a quantitative ground to explore the propagation of activity in the cortex.