Miracle-dz/UniFAR-FTUs huggingface dataset:
Cytoplasmic Recycling of 60 S Preribosomal Factors Depends on the AAA Protein Drg 1 †

HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés. Cytoplasmic recycling of 60S preribosomal factors depends on the AAA protein Drg1 Brigitte Pertschy, Cosmin Saveanu, Gertrude Zisser, Alice Lebreton, Martin Tengg, Alain Jacquier, Eva Liebminger, Berthold Nobis, Lisa Kappel, Ida Van Der Klei, et al.
In-process control of distortion in wire and arc additive manufacturing based on a flexible multi-point support fixture

Distortion induced by non-uniform thermal gradients is one of the major constraints in wire and arc additive manufacturing. A novel flexible multi-point support fixture (FMSF) featured by reconfigured working surface and controllable restraining force is developed as an in-process distortion control technique. FMSF allows the distortion to be suppressed by adjusting the restraining force imposed onto the substrate dynamically as the number of layers increases. Both simulations and experiments are conducted to verify its effectiveness and compare it with other common restraint forms including clamping and pre-springing. The multi-layer deposition results show that a reduction of 96.3% in angular distortion and 86.5% in longitudinal bending distortion are obtained with FMSF, which exhibits great superiority over clamping and pre-springing.
Cosmology and Fundamental Physics with the Euclid Satellite

Euclid is a European Space Agency medium-class mission selected for launch in 2019 within the Cosmic Vision 2015–2025 program. The main goal of Euclid is to understand the origin of the accelerated expansion of the universe. Euclid will explore the expansion history of the universe and the evolution of cosmic structures by measuring shapes and red-shifts of galaxies as well as the distribution of clusters of galaxies over a large fraction of the sky.Although the main driver for Euclid is the nature of dark energy, Euclid science covers a vast range of topics, from cosmology to galaxy evolution to planetary research. In this review we focus on cosmology and fundamental physics, with a strong emphasis on science beyond the current standard models. We discuss five broad topics: dark energy and modified gravity, dark matter, initial conditions, basic assumptions and questions of methodology in the data analysis.This review has been planned and carried out within Euclid’s Theory Working Group and is meant to provide a guide to the scientific themes that will underlie the activity of the group during the preparation of the Euclid mission.
Alterations at the Cross-Bridge Level Are Associated with a Paradoxical Gain of Muscle Function In Vivo in a Mouse Model of Nemaline Myopathy

Nemaline myopathy is the most common disease entity among non-dystrophic skeletal muscle congenital diseases. The first disease causing mutation (Met9Arg) was identified in the gene encoding α-tropomyosinslow gene (TPM3). Considering the conflicting findings of the previous studies on the transgenic (Tg) mice carrying the TPM3 Met9Arg mutation, we investigated carefully the effect of the Met9Arg mutation in 8–9 month-old Tg(TPM3)Met9Arg mice on muscle function using a multiscale methodological approach including skinned muscle fibers analysis and in vivo investigations by magnetic resonance imaging and 31-phosphorus magnetic resonance spectroscopy. While in vitro maximal force production was reduced in Tg(TPM3)Met9Arg mice as compared to controls, in vivo measurements revealed an improved mechanical performance in the transgenic mice as compared to the former. The reduced in vitro muscle force might be related to alterations occuring at the cross-bridges level with muscle-specific underlying mechanisms. In vivo muscle improvement was not associated with any changes in either muscle volume or energy metabolism. Our findings indicate that TPM3(Met9Arg) mutation leads to a mild muscle weakness in vitro related to an alteration at the cross-bridges level and a paradoxical gain of muscle function in vivo. These results clearly point out that in vitro alterations are muscle-dependent and do not necessarily translate into similar changes in vivo.
Prenatal and Postnatal Developmental Changes of Testes of Albino Rats

Copyright: © the author(s), publisher. Annals of International Medical and Dental Research (AIMDR) is an Official Publication of “Society for Health Care & Research Development”. It is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Educational Attainment and Smoking Status in a National Sample of American Adults; Evidence for the Blacks’ Diminished Return

Background: Although higher socioeconomic status (SES) indicators such as educational attainment are linked with health behaviors, the Blacks’ Diminished Return theory posits that the protective effects of SES are systemically smaller for Blacks than Whites. Aims: To explore the Black/White differences in the association between education and smoking. Methods: This cross-sectional study used the Health Information National Trends Survey (HINTS) 2017 (n = 3217). HINTS is a national survey of American adults. The current analysis included 2277 adults who were either Whites (n = 1868; 82%) or Blacks (n = 409; 18%). The independent variable was educational attainment, and the dependent variables were ever and current (past 30-day) smoking. Demographic factors (age and gender) were covariates. Race was the focal moderator. Results: In the pooled sample, higher educational attainment was associated with lower odds of ever and current smoking. Race interacted with the effects of higher educational attainment on current smoking, suggesting a stronger protective effect of higher education against current smoking for Whites than Blacks. Race did not interact with the effect of educational attainment on odds of ever smoking. Conclusions: In line with previous research in the United States, education is more strongly associated with health and health behaviors in Whites than Blacks. Smaller protective effects of education on health behaviors may be due to the existing racism across institutions such as the education system and labor market.
Development of an Internet-Administered Cognitive Behavior Therapy Program (ENGAGE) for Parents of Children Previously Treated for Cancer: Participatory Action Research Approach

Background Parenting a child through cancer is a distressing experience, and a subgroup of parents report negative long-term psychological consequences years after treatment completion. However, there is a lack of evidence-based psychological interventions for parents who experience distress in relation to a child’s cancer disease after end of treatment. Objective One aim of this study was to develop an internet-administered, cognitive behavior therapy–based, psychological, guided, self-help intervention (ENGAGE) for parents of children previously treated for cancer. Another aim was to identify acceptable procedures for future feasibility and efficacy studies testing and evaluating the intervention. Methods Participatory action research methodology was used. The study included face-to-face workshops and related Web-based exercises. A total of 6 parents (4 mothers, 2 fathers) of children previously treated for cancer were involved as parent research partners. Moreover, 2 clinical psychologists were involved as expert research partners. Research partners and research group members worked collaboratively throughout the study. Data were analyzed iteratively using written summaries of the workshops and Web-based exercises parallel to data collection. Results A 10-week, internet-administered, cognitive behavior therapy–based, psychological, guided, self-help intervention (ENGAGE) was developed in collaboration with parent research partners and expert research partners. The content of the intervention, mode and frequency of e-therapist support, and the individualized approach for feedback were modified based on the research partner input. Shared solutions were reached regarding the type and timing of support from an e-therapist (eg, initial video or telephone call, multiple methods of e-therapist contact), duration and timing of intervention (eg, 10 weeks, 30-min assessments), and the removal of unnecessary support functions (eg, removal of chat and forum functions). Preferences for study procedures in future studies testing and evaluating the intervention were discussed; consensus was not reached for all aspects. Conclusions To the best of our knowledge, this study is the first use of a participatory action research approach to develop a psychological intervention for parents of children previously treated for cancer and to identify acceptable study procedures. Involvement of parents with lived experience was vital in the development of a potentially relevant and acceptable intervention for this population.
The Ideological-Conflict Hypothesis

Decades of research in social and political psychology have demonstrated that political conservatives appear more intolerant toward a variety of groups than do political liberals. Recent work from our three independent labs has challenged this conventional wisdom by suggesting that some of the psychological underpinnings of intolerance are not exclusive to people on either end of the political spectrum. These studies have demonstrated that liberals and conservatives express similar levels of intolerance toward ideologically dissimilar and threatening groups. We suggest directions for future research and discuss the psychological and political implications of our conclusions.
FokI and BsmI Polymorphisms of the VDR Gene and Breast Cancer Risk

Introduction: Vitamin D fulfills its crucial role in cell proliferation and death through signal transduction into the nucleus by vitamin D receptor (VDR). Recent studies have depicted the association between VDR gene polymorphisms and different cancers, including breast cancer. This study attempted to consider the relationship between VDR gene polymorphisms and breast cancer risk among women in West Azerbaijan Province, Iran. Methods: FokI and BsmI polymorphisms were studied through the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique on blood samples taken from 95 cancer and 71 healthy participants from Urmia City. The association between the mentioned polymorphisms and breast cancer risk was considered using calculated odds ratio (OR). Results: The findings showed the protective effect of the FokI polymorphism in breast cancer development (OR = 0.2731), while no statistically significant correlation was observed between breast cancer and BsmI polymorphism (P > 0.05). Conclusions: This study identified the protective effect of the FokI polymorphism in breast cancer, and the absence of statistically significant association between BsmI polymorphism
Perception of the Quality of Physiotherapy Care Provided to Outpatients from Primary Health Care in Chile

We explored outpatient’s perceptions on the quality of physiotherapy care provided in three urban primary care centers of Valdivia, Chile, through a descriptive phenomenological study. We collected data from 21 participants through semistructured interviews which were analyzed using the Colaizzi approach. Two main themes emerged: quality related to the professional and structure of the care system. Perceptions about the care received from the physiotherapist are influenced by factors such as communication, the way they treat the patient, and the trust established between patient and professional. In addition, structural aspects such as allocation of spaces, technical equipment and rehabilitation devices, access to centers, and the availability of the physiotherapist affect satisfaction and the perception of the quality of the service received. As it occurs in other health services provided by different health-care professionals, the quality of physiotherapy care is related to subjective (relational) and objective (structural) perceptions.
Using network theory and machine learning to predict El Niño

Abstract. The skill of current predictions of the warm phase of the El Niño Southern Oscillation (ENSO) reduces significantly beyond a lag time of 6 months. In this paper, we aim to increase this prediction skill at lag times of up to 1 year. The new method combines a classical autoregressive integrated moving average technique with a modern machine learning approach (through an artificial neural network). The attributes in such a neural network are derived from knowledge of physical processes and topological properties of climate networks, and they are tested using a Zebiak–Cane-type model and observations. For predictions up to 6 months ahead, the results of the hybrid model give a slightly better skill than the CFSv2 ensemble prediction by the National Centers for Environmental Prediction (NCEP). Interestingly, results for a 12-month lead time prediction have a similar skill as the shorter lead time predictions.
A New Dolabrane Dinorditerpene from Ceriops tagal

A new dolabrane dinorditerpene, tagalsine X(1), was isolated from the leaves of Ceriops tagal, along with five known analogues (2-6). Their structures were established on the basis of spectroscopic data or comparison with the literatural data. Their cytotoxic activities against four human carcinoma cell lines (CNE-2, HCT-116, HepG2and A549) were also evaluated, which displayed that only compound 2 had significant cytotoxicity against those cell lines with IC50 values of 13.57, 42.32, 11.21 and 15.23 μM, respectively.
Line Force and Damping at Full and Partial Stator Overlap in a Linear Generator for Wave Power

A full scale linear generator for wave power has been experimentally evaluated by measuring the line force and translator position throughout the full translator stroke. The measured line force, in relation to translator speed, generator damping and stator overlap, has been studied by comparing the line force and the damping coefficient, γ , for multiple load cases along the translator stroke length. The study also compares the generator’s behavior during upward and downward motion, studies oscillations and determines the no load losses at two different speeds. The generator damping factor, γ , was determined for five different load cases during both upward and downward motion. The γ value was found to be constant for full stator overlap and to decrease linearly with a decreasing overlap, as the translator moved towards the endstops. The decline varied with the external load case, as previously suggested but not shown. In addition, during partial stator overlap, a higher γ value was noted as the translator was leaving the stator, compared to when it was entering the stator. Finally, new insights were gained regarding how translator weight and generator damping will affect the translator downward motion during offshore operation. This is important for power production and for avoiding damaging forces acting on the wave energy converter during operation.
The use of sonication treatment to completely decellularize blood arteries: A pilot study

We have developed a novel sonication decellularization system to prepare completely decellularized bioscaffolds in a short treatment time. The aim of the study is to investigate the sonication decellularization efficiency and its relation with ultrasonic power output and dissolved oxygen (DO) concentration in different detergent solution. In the study, we used aorta samples to evaluate sonication decellularization efficiency, which assessed treatment duration, sonication power and SDS detergent with/without saline. The treated samples were evaluated histologically by Hematoxylin Eosin (HE) staining and scanning electron microscopic (SEM) photographs. The concentration of DO was monitored to identify the effect of sonication on cavitation-related DO concentration in the solution. From histological results, the sonication decellularization efficiency was better than the other preparation methods. Decellularization efficiency was tended to increase significantly when DO value decreasing after 6 hours of treatment. In conclusion, we conclude that sonication treatment can be used to prepare the complete decellularized scaffolds in short treatment time.
Microfluidic FACS becoming real

IN the past decade, a number of efforts were taken to miniaturize fluorescence-activated cell sorting (FACS), even attempting for “single-used” FACS. The motivations behind seem to be sound and clear. FACS is expensive and labor intensive compared to most bioanalytical instruments. The aerosol induced during sorting also triggers biosafety concerns (1). Meanwhile, FACS miniaturization also becomes more realistic than ever with rapidly developing technologies, especially microfluidics. Today a variety of miniaturized sorting techniques are available: some stay with cell-marker-based sorting just like FACS (2,3) but some sort cells by their specific physical properties (4). The recent report by Zhao et al. proposed a novel method of generic bubble-based microfluidic cell sorting (5). After all, whether FACS should be miniaturized, in which style, is largely dependent on why and where cells sorting is needed, and on the pros and cons of the novel technologies.
ParB spreading requires DNA bridging

The bacterial parABS system is employed for plasmid partitioning and chromosome segregation. ParB binds to parS sites and associates with broad regions of adjacent DNA, a phenomenon known as spreading. However, the molecular basis for spreading is unknown. Using single-molecule approaches, Graham et al. demonstrate DNA bridging by B. subtilis ParB (Spo0J). Spo0J mutations that disrupt DNA bridging lead to defective spreading and SMC condensin complex recruitment. This study suggests a novel, conserved mechanism by which ParB proteins function in chromosome organization and segregation.
Evaluation of surface roughness during turning of Al-SiC and Al-SiC-Gr composites

Purpose In the current scenario, new materials are gaining popularity due to higher specific properties of strength and stiffness, increase in wear resistance, dimensional stability at higher temperature, etc. Subsequently, the need for precise machining has also been increased enormously. The purpose of this paper is to study the surface roughness during the turning of Al-10%SiC and Al-5%SiC-5%Gr composites under different cutting conditions. Design/methodology/approach Artificial neural network (ANN) has been effectively employed in solving problems with effortless computation in the areas such as fault diagnosis, process identification, property estimation, data smoothing and error filtering, product design and development, optimisation and estimation of activity coefficients. Response surface method is also used to analyse the problems involving a number of input parameters and their corresponding relationship between one or more measured dependent responses. Using Design Expert.8 evaluation software package, a simpler and more efficient statistical RSM model has been designed. RSM models are created by using 27 experimental data measurements obtained from different turning conditions of aluminium alloy composites. Findings In this work, the surface roughness during turning of Al-10%SiC and Al-5%SiC-5%Gr composites under different cutting conditions has been studied. The surface roughness value is proportional with the increase in feed rate and depth of cut while inversely proportional with the cutting speed. In all turning conditions, Al-10%SiC composite has lower surface roughness values than Al-5%SiC-5%Gr hybrid composite. An ANN and response surface models have been developed to predict the surface roughness of machined surface. The experimental results concur well with predicted models. Originality/value In the present trend, new materials are gaining popularity due to higher specific properties of strength and stiffness, increase in wear resistance, dimensional stability at higher temperature, etc. Subsequently, the need for precise machining has also been increased enormously. In this work, the surface roughness during turning of Al-10%SiC and Al-5%SiC-5%Gr composites under different cutting conditions has been studied.
Design and low-temperature characterization of a tunable microcavity for diamond-based quantum networks

We report on the fabrication and characterization of a Fabry-Perot microcavity enclosing a thin diamond membrane at cryogenic temperatures. The cavity is designed to enhance resonant emission of single nitrogen-vacancy centers by allowing spectral and spatial tuning while preserving the optical properties observed in bulk diamond. We demonstrate cavity finesse at cryogenic temperatures within the range of F ¼ 4000–12 000 and find a sub-nanometer cavity stability. Modeling shows that coupling nitrogen-vacancy centers to these cavities could lead to an increase in remote entanglement success rates by three orders of magnitude.
A subject-independent brain-computer interface based on smoothed, second-order baselining

A brain-computer interface (BCI) enables direct communication from the brain to devices, bypassing the traditional pathway of peripheral nerves and muscles. Traditional approaches to BCIs require the user to train for weeks or even months to learn to control the BCI. In contrast, BCIs based on machine learning only require a calibration session of less than an hour before the system can be used, since the machine adapts to the user's existing brain signals. However, this calibration session has to be repeated before each use of the BCI due to inter-session variability, which makes using a BCI still a time-consuming and an error-prone enterprise. In this work, we present a second-order baselining procedure that reduces these variations, and enables the creation of a BCI that can be applied to new subjects without such a calibration session. The method was validated with a motor-imagery classification task performed by 109 subjects. Results showed that our subject-independent BCI without calibration performs as well as the popular common spatial patterns (CSP)-based BCI that does use a calibration session.
Laser-assisted vascular welding: op miza on of acute and post-hydra on welding strength

1 Department of Cardio -thoracic Surgery, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands 2 Department of Surgery, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands 3 Department of Physiology, Faculty of Medicine, Hasanuddin University, Jl, Makassar, South Sulawesi, Indonesia 4 Department of Experimental Surgery, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands 5 Department of Biomedical Engineering, Material Technology, Technical University Eindhoven, the Netherlands 6 HemoLab, Den Dolech 2, 5612 AZ Eindhoven, the Netherlands 7 Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands 8 Department of Biomedical Engineering and Physics, Academic Medical Center, University of Amsterdam, the Netherlands