Miracle-dz/UniFAR-FTUs huggingface dataset:
No evidence for a bioenergetic advantage from forced swimming in rainbow trout under a restrictive feeding regime

Sustained swimming at moderate speeds is considered beneficial in terms of the productive performance of salmonids, but the causative mechanisms have yet to be unequivocally established. In the present study, the effects of moderate exercise on the bioenergetics of rainbow trout were assessed during a 15 week growth experiment, in which fish were reared at three different current speeds: 1 BL s−1, 0.5 BL s−1 and still water (≈ 0 BL s−1). Randomly selected groups of 100 fish were distributed among twelve 600 L tanks and maintained on a restricted diet regime. Specific growth rate (SGR) and feed conversion ratio (FCR) were calculated from weight and length measurements every 3 weeks. Routine metabolic rate (RMR) was measured every hour as rate of oxygen consumption in the tanks, and was positively correlated with swimming speed. Total ammonia nitrogen (TAN) excretion rates showed a tendency to decrease with increasing swimming speeds, yet neither they nor the resulting nitrogen quotients (NQ) indicated that swimming significantly reduced the fraction of dietary protein used to fuel metabolism. Energetic budgets revealed a positive correlation between energy expenditure and the current speed at which fish were reared, fish that were forced to swim and were fed restrictively consequentially had poorer growth and feed utilization. The results show that for rainbow trout, water current can negatively affect growth despite promoting minor positive changes in substrate utilization. We hypothesize that this may be the result of either a limited dietary energy supply from diet restriction being insufficient for both covering the extra costs of swimming and supporting enhanced growth.
Tying Word Vectors and Word Classifiers: A Loss Framework for Language Modeling

Recurrent neural networks have been very successful at predicting sequences of words in tasks such as language modeling. However, all such models are based on the conventional classification framework, where the model is trained against one-hot targets, and each word is represented both as an input and as an output in isolation. This causes inefficiencies in learning both in terms of utilizing all of the information and in terms of the number of parameters needed to train. We introduce a novel theoretical framework that facilitates better learning in language modeling, and show that our framework leads to tying together the input embedding and the output projection matrices, greatly reducing the number of trainable variables. Our framework leads to state of the art performance on the Penn Treebank with a variety of network models.
Tactile Retina for Slip Detection

The interest in tactile sensors is increasing as their use in complex unstructured environments is demanded, like in telepresence, minimal invasive surgery, robotics etc. The array of pressure data provided by these devices can be treated with different image processing algorithms to extract the required information. However, as in the case of vision chips or artificial retinas, problems arise when the array size and the computation complexity increase. Having a look at the skin, the information collected by every mechanoreceptor is not sent to the brain for its processing, but some complex pre-processing is performed to fit the limited throughput of the nervous system. This is specially important for high bandwidth demanding tasks. Experimental works report that neural response of skin mechanoreceptors encodes the change in local shape from an offset level rather than the absolute force or pressure distributions. Something similar happens in the retina, which implements a spatio-temporal averaging. We propose the same strategy in tactile preprocessing, and we show preliminary results illustrated for the case of slip detection, which is certainly demanding in computing requirements
Lateral Spread of Orientation Selectivity in V1 is Controlled by Intracortical Cooperativity

Neurons in the primary visual cortex receive subliminal information originating from the periphery of their receptive fields (RF) through a variety of cortical connections. In the cat primary visual cortex, long-range horizontal axons have been reported to preferentially bind to distant columns of similar orientation preferences, whereas feedback connections from higher visual areas provide a more diverse functional input. To understand the role of these lateral interactions, it is crucial to characterize their effective functional connectivity and tuning properties. However, the overall functional impact of cortical lateral connections, whatever their anatomical origin, is unknown since it has never been directly characterized. Using direct measurements of postsynaptic integration in cat areas 17 and 18, we performed multi-scale assessments of the functional impact of visually driven lateral networks. Voltage-sensitive dye imaging showed that local oriented stimuli evoke an orientation-selective activity that remains confined to the cortical feedforward imprint of the stimulus. Beyond a distance of one hypercolumn, the lateral spread of cortical activity gradually lost its orientation preference approximated as an exponential with a space constant of about 1 mm. Intracellular recordings showed that this loss of orientation selectivity arises from the diversity of converging synaptic input patterns originating from outside the classical RF. In contrast, when the stimulus size was increased, we observed orientation-selective spread of activation beyond the feedforward imprint. We conclude that stimulus-induced cooperativity enhances the long-range orientation-selective spread.
Rural Education: The Problems and Potential of Smallness.

292 Rural education, or more accurately, schooling in non-metropolitan America, isn't what it used to be. Virtually gone from the countryside are the one-room elementary schools which graduated many of their eighth graders directly into the adult work force. In their place are consolidated elementary and secondary schools patterned after their suburban counterparts, but frequently lacking the resources to fully meet the requirements of the "one best system" (Tyack, 1974). While consolidation significantly changed rural education, it did not produce parity with urban schools. A significant gap remains today.
Player agency in interactive narrative: audience, actor& author

The question motivating this review paper is, how can computer-based interactive narrative be used as a constructivist learn- ing activity? The paper proposes that player agency can be used to link interactive narrative to learner agency in constructivist theory, and to classify approaches to interactive narrative. The traditional question driving research in interactive narrative is, ‘how can an in- teractive narrative deal with a high degree of player agency, while maintaining a coherent and well-formed narrative? ’ This question derives from an Aristotelian approach to interactive narrative that, as the question shows, is inherently antagonistic to player agency. Within this approach, player agency must be restricted and manip- ulated to maintain the narrative. Two alternative approaches based on Brecht’s Epic Theatre and Boal’s Theatre of the Oppressed are reviewed. If a Boalian approach to interactive narrative is taken the conflict between narrative and player agency dissolves. The question that emerges from this approach is quite different from the traditional question above, and presents a more useful approach to applying in- teractive narrative as a constructivist learning activity.
Novel circuit technique for reduction of active drain current in series/parallel PMOS transistors stack

Stacking of MOS transistors [1] is used for minimization of standby current in Nano-scale CMOS circuits. Stacking of PMOS is preferred over NMOS because value of active drain current in PMOS is less than NMOS. It results because of mobility of holes in PMOS is less than mobility of electrons in NMOS [2]. In this paper we observed active drain current consumption by series/parallel combination of two and three PMOS transistors. This observation leads to propose the novel technique for reduction of active drain current in series/parallel PMOS assembly. The effect of VGS, VDS, VSB and intermediates node voltages is also addressed. The proposed circuit is simulated for TSMC 0.18 µm technology using Spice© simulator
Mild cognitive impairment, poor episodic memory, and late-life depression are associated with cerebral cortical thinning and increased white matter hyperintensities

In various independent studies to date, cerebral cortical thickness and white matter hyperintensity (WMH) volume have been associated with episodic memory, depression, and mild cognitive impairment (MCI). The aim of this study was to uncover variations in cortical thickness and WMH volume in association with episodic memory, depressive state, and the presence of MCI simultaneously in a single study population. The participants were 186 individuals with MCI (clinical dementia rating [CDR] of 0.5) and 136 healthy elderly controls (HCs; CDR of 0) drawn from two community-based cohort studies in northern Japan. We computed cerebral cortical thickness and WMH volume by using MR scans and statistically analyzed differences in these indices between HCs and MCI participants. We also assessed the associations of these indices with memory performance and depressive state in participants with MCI. Compared with HCs, MCI participants exhibited thinner cortices in the temporal and inferior parietal lobes and greater WMH volumes in the corona radiata and semioval center. In MCI participants, poor episodic memory was associated with thinner cortices in the left entorhinal region and increased WMH volume in the posterior periventricular regions. Compared with non-depressed MCI participants, depressed MCI participants showed reduced cortical thickness in the anterior medial temporal lobe and gyrus adjacent to the amygdala bilaterally, as well as greater WMH volume as a percentage of the total intracranial volume (WMHr). A higher WMHr was associated with cortical thinning in the frontal, temporal, and parietal regions in MCI participants. These results demonstrate that episodic memory and depression are associated with both cortical thickness and WMH volume in MCI participants. Additional longitudinal studies are needed to clarify the dynamic associations and interactions among these indices.
Parental-caregiver perceptions of child oral health-related quality of life (P-CPQ): Psychometric properties for the peruvian spanish language

Objectives: The aim of the study was to cross-culturally adapt the Parental-Caregiver Perceptions Questionnaire (P-CPQ) to the Peruvian Spanish language and assess its reliability and validity. Study Design: To translate and cross-cultural adapt the instrument, 60 parents answered the P-CPQ in two pilot tests. The final version of the P-CPQ was evaluated in 200 parents of children aged 11 to 14 years, who were clinically examined for dental caries. The internal consistency was assessed by Cronbach’s alpha coefficient while repeat administration of the P-CPQ on the same 200 children facilitated the test-retest reliability via intraclass correlation coefficient (ICC). Construct and discriminant validity were based on associations of the P-CPQ with global ratings of oral health and clinical groups, respectively. Results: The mean (standard deviation) P-CPQ score was 15.64 (11.89). Internal consistency was confirmed by a Cronbach’s alpha of 0.84. Test-retest reliability revealed excellent reproducibility (ICC= 0.94). Construct validity was satisfactory, demonstrating significant correlations between global ratings (oral health and overall well-being) and the total scale and for subscale. Discriminant validity was significant (p<0.001), supporting its ability to discriminate between clinical groups. Conclusions: The Peruvian Spanish P-CPQ has satisfactory psychometric properties to assess parental-caregivers perceptions on their children’s oral health-related quality of life. Key words:Quality of life, oral health, children, validity, reliability.
Quantum-Dot Lasers—Desynchronized Nonlinear Dynamics of Electrons and Holes

We analyze the complex turn-on behavior of semiconductor quantum-dot (QD) lasers in terms of a nonlinear rate equation model for the electron and hole densities in the QDs and the wetting layer, and the photons. A basic ingredient of the model is the nonlinearity of the microscopic carrier-carrier scattering rates. With the framework of detailed balance, we analytically relate the microscopic in- and out-scattering rates. We gain insight into the anomalous nonlinear dynamics of QD lasers by a detailed analysis of various sections of the 5-D phase space, accounting for density-dependent carrier scattering times. We show that the strongly damped relaxation oscillations are characterized by a desynchronization of electron and hole dynamics in the dots. Analytic approximations for the steady-state characteristics are also derived.
Circuit Fingerprinting Attacks: Passive Deanonymization of Tor Hidden Services

This paper sheds light on crucial weaknesses in the design of hidden services that allow us to break the anonymity of hidden service clients and operators passively. In particular, we show that the circuits, paths established through the Tor network, used to communicate with hidden services exhibit a very different behavior compared to a general circuit. We propose two attacks, under two slightly different threat models, that could identify a hidden service client or operator using these weaknesses. We found that we can identify the users' involvement with hidden services with more than 98% true positive rate and less than 0.1% false positive rate with the first attack, and 99% true positive rate and 0.07% false positive rate with the second. We then revisit the threat model of previous website fingerprinting attacks, and show that previous results are directly applicable, with greater efficiency, in the realm of hidden services. Indeed, we show that we can correctly determine which of the 50 monitored pages the client is visiting with 88% true positive rate and false positive rate as low as 2.9%, and correctly deanonymize 50 monitored hidden service servers with true positive rate of 88% and false positive rate of 7.8% in an open world setting.
Molecular mechanisms of myocardial remodeling.

"Remodeling" implies changes that result in rearrangement of normally existing structures. This review focuses only on permanent modifications in relation to clinical dysfunction in cardiac remodeling (CR) secondary to myocardial infarction (MI) and/or arterial hypertension and includes a special section on the senescent heart, since CR is mainly a disease of the elderly. From a biological point of view, CR is determined by 1 ) the general process of adaptation which allows both the myocyte and the collagen network to adapt to new working conditions; 2) ventricular fibrosis, i.e., increased collagen concentration, which is multifactorial and caused by senescence, ischemia, various hormones, and/or inflammatory processes; 3) cell death, a parameter linked to fibrosis, which is usually due to necrosis and apoptosis and occurs in nearly all models of CR. The process of adaptation is associated with various changes in genetic expression, including a general activation that causes hypertrophy, isogenic shifts which result in the appearance of a slow isomyosin, and a new Na+-K+-ATPase with a low affinity for sodium, reactivation of genes encoding for atrial natriuretic factor and the renin-angiotensin system, and a diminished concentration of sarcoplasmic reticulum Ca2+-ATPase, beta-adrenergic receptors, and the potassium channel responsible for transient outward current. From a clinical point of view, fibrosis is for the moment a major marker for cardiac failure and a crucial determinant of myocardial heterogeneity, increasing diastolic stiffness, and the propensity for reentry arrhythmias. In addition, systolic dysfunction is facilitated by slowing of the calcium transient and the downregulation of the entire adrenergic system. Modifications of intracellular calcium movements are the main determinants of the triggered activity and automaticity that cause arrhythmias and alterations in relaxation.
The importance of clinical leadership in service redesign : Experience in three English National Health Service Hospitals

Purpose – The way change occurred at a strategic level and in four clinical services in three hospitals was examined. The purpose of this paper is to report how the hospitals designed and delivered change at organisational and clinical service level to improve services for patients, and the role of clinical leadership in this process. Design/methodology/approach – A comparative case study involving semi-structured interviews was undertaken. These involved a range of senior managers in 2009 (n=77), 2011 (n=21) and 2012 (n=29). Interviews with staff involved directly in service delivery were also carried out in 2011 (n=92). The interviews were recorded digitally, transcribed verbatim, and analysed thematically using the Framework Method. Findings – The value of, and approach taken to clinical leadership varied across the hospitals and over time. This was affected by the culture and priorities of the organisation. Some strategies for developing clinical leadership were developed, however they were limited. I.
A Kind of prediction from superstring model building

Assuming that the Standard Model of particle physics arises from the E8 × E8 Heterotic String Theory, we try to solve the discrepancy between the unification scale predicted by this theory ( ≈ gGUT × 5.27⋅1017 GeV) and the value deduced from LEP experiments ( ≈ 2⋅1016 GeV). A crucial ingredient in our solution is the presence at low energies of three generations of supersymmetric Higgses and vector-like colour triplets. As a by-product our analysis gives rise to a strategy which might be useful when constructing realistic models.
Occurrence of Mycobacterium bovis and non-tuberculous mycobacteria (NTM) in raw and pasteurized milk in the northwestern region of Paraná, Brazil

Milk is widely consumed in Brazil and can be the vehicle of agent transmission. In this study, was evaluated the occurrence of Mycobacterium bovis and non-tuberculous mycobacteria (NTM) in raw and pasteurized milk consumed in the northwestern region of Paraná, Brazil. Fifty-two milk samples (20 pasteurized and 32 raw) from dairy farms near the municipality of Maringa, Parana State, Brazil were collected. Milk samples were decontaminated using 5% oxalic acid method and cultured on Lowenstein-Jensen and Stonebrink media at 35 °C and 30 °C, with and without 5–10% CO2. Mycobacteria isolates were identified by morphological features, PCR-Restriction Fragment Length Polymorphism Analysis (PCR-PRA) and Mycolic acids analysis. Thirteen (25%) raw and 2 (4%) pasteurized milk samples were positive for acid fast bacilli growth. Nine different species of NTM were isolated (M. nonchromogenicum, M. peregrinum, M. smegmatis, M. neoaurum, M. fortuitum, M. chelonae, M. flavescens, M. kansasii and M. scrofulaceum). M. bovis was not detected. Raw and pasteurized milk may be considered one source for NTM human infection. The paper reinforces the need for intensification of measures in order to avoid the milk contamination and consequently prevent diseases in the south of Brazil.
Quantitative work demands, emotional demands, and cognitive stress symptoms in surgery nurses

Abstract In surgery, cognitive stress symptoms, including problems in concentrating, deciding, memorising, and reflecting are risks to patient safety. Recent evidence points to social stressors as antecedents of cognitive stress symptoms in surgery personnel. The current study tests whether cognitive stress symptoms are positively associated with emotional abuse, emotional- and task-related demands and resources in surgery work. Forty-eight surgery nurses from two hospitals filled out the Copenhagen Psychosocial Questionnaire in its German version. Task-related and emotional demands were positively related to cognitive stress symptoms. In a stepwise, multiple, linear regression of cognitive stress symptoms on task-related and emotional demands, emotional abuse and emotional demands were unique predictors (p < .05). Efforts to increase patient safety should address emotional abuse, emotional demands, and, therefore, communication and cooperation team climate in surgery personnel.
An adaptive approach for removing impulsive noise in digital images

A new approach is proposed to eliminate impulsive noise with Gaussian or uniform random distribution in digital images. The method is based on impulse noise detection by means of a self-organizing neural network and a class of noise-exclusive adaptive filters. The filtering scheme presented can suppress impulse noise effectively as well as preserving image edges and fine details. Experimental results demonstrated that the performance of the noise-exclusive adaptive filters are superior to that of traditional median filter, central weighted median filter and multistage median filter.
Repression of metadherin inhibits biological behavior of prostate cancer cells and enhances their sensitivity to cisplatin

Metadherin (MTDH), also known as astrocyte-elevated gene-1, was first cloned in 2002 and has been confirmed as an oncogene in numerous types of cancer by previous studies. Overexpression of MTDH has been observed in multiple types of cancer, including breast, esophageal, prostate, cervical and non-small-cell lung cancer, as well as neuroblastoma and hepatocellular carcinoma. However, at present, few investigations into MTDH-associated prostate cancer have been performed. A previous study suggested that MTDH was expressed at higher levels in prostate cancer samples, compared with those of benign prostatic hyperplasia. The present study aimed to elucidate the effects of MTDH as an oncogene associated with the biological behavior of prostate cancer cells and chemotherapy-sensitivity to cisplatin in vitro. It was demonstrated that the inhibition of MTDH expression promoted cell apoptosis, reduced cell viability and weakened the invasive ability of prostate cancer cells. In addition, the suppression of MTDH expression increased cell sensitivity to cisplatin. Furthermore, it was demonstrated that MTDH-associated phosphoinositide 3-kinase/Akt signaling pathways may be involved in mediating the biological behavior of prostate cancer.