Miracle-dz/UniFAR-FTUs huggingface dataset:
Chemotherapy-Induced Cardiotoxicity: Pathophysiology and Prevention

Along with the remarkable progress registered in oncological treatment that led to increased survival of cancer patients, treatment-related comorbidities have also become an issue for these long-term survivors. Of particular interest is the development of cardiotoxic events, which, even when asymptomatic, not only have a negative impact on the patient`s cardiac prognosis, but also considerably restrict therapeutic opportunities. The pathophysiology of cytostatic-induced cardiotoxicity implies a series of complex and intricate mechanisms, whose understanding enables the development of preventive and therapeutic strategies. Securing cardiac function is an ongoing challenge for the pharmaceutical industry and the physicians who have to deal currently with these adverse reactions. This review focuses on the main mechanism of cardiac toxicity induced by anticancer drugs and especially on the current strategies applied for preventing and minimizing the cardiac side effects.
Differential Recruitment of Anterior Intraparietal Sulcus and Superior Parietal Lobule during Visually Guided Grasping Revealed by Electrical Neuroimaging

Dorsal parietal cortex is required for visually guided prehension. Transcranial magnetic stimulation to either the anterior intraparietal sulcus (aIPS) or superior parietal lobule (SPL) disrupts on-line adaptive adjustments of grasp when objects are perturbed. We used high-density electroencephalography during grasping to determine the relative timing of these two areas and to test whether the temporal contribution of each site would change when the task goal was perturbed. During object grasping with the right-hand, two distinct evoked responses were present over the 50–100 and 100–200 ms periods after movement onset. Distributed linear source estimation of these scalp potentials localized left lateralized sources, first in the aIPS and then the SPL. The duration of the response from the aIPS area was longer when there was an object perturbation. Initiation of a corrective movement coincided with activation in SPL. These data support a two-stage process: the integration of target goal and an emerging action plan within aIPS and subsequent on-line adjustments within SPL.
The Cross‐Polar Cap Saturation in GUMICS‐4 During High Solar Wind Driving

It is well known that the Earth's ionospheric cross‐polar cap potential (CPCP) saturates as a response to the solar wind (SW) driver especially when the level of driving is high and the interplanetary magnetic field is oriented southward. Moreover, previous studies have shown that the upstream Alfvén Mach number may be an important factor in the saturation effect. While the CPCP is often viewed as a measure of the SW‐magnetosphere‐ionosphere coupling, the processes associated with the nonlinearity of the coupling remain an open issue. We use fourth edition of the Grand Unified Magnetosphere‐Ionosphere Coupling Simulation (GUMICS‐4) and artificial SW data to mimic weak and strong driving in order to study the CPCP response to a wide range of interplanetary magnetic field magnitudes (3.5–30 nT) and upstream Alfvén Mach number values (1.2–22). The results provide the first overview of the CPCP saturation in GUMICS‐4 and show that the onset of saturation is strongly dependent on the upstream Alfvén Mach number and the physical processes responsible for the saturation effect might take place both in the Earth's magnetosheath and in the upstream SW.
Photosynthesis–irradiance responses in the Ross Sea, Antarctica: a meta-analysis

Abstract. A meta-analysis of photosynthesis–irradiance measurements was completed using data from the Ross Sea, Antarctica, using a total of 417 independent measurements. PmB, the maximum, chlorophyll-specific, irradiance-saturated rate of photosynthesis, averaged 1.1 ± 0.06 μg C (μg Chl)−1 h−1. Light-limited, chlorophyll-specific photosynthetic rates (αB) averaged 0.030 ± 0.023 μg C (μg Chl)−1 h−1 (μmol quanta m−2 s−1)−1. Significant variations in PmB and αB were found as a function of season, with spring maximum photosynthetic rates being 60% greater than those in summer. Similarly, α values were 48% greater in spring. There was no detectable effect of sampling location on the photo-synthetic parameters, and temperature and macronutrient (NO3) concentrations also did not have an influence. However, irradiance and carbon dioxide concentrations, when altered under controlled conditions, exerted significant influences on photosynthetic parameters. Specifically, reduced irradiance resulted in significantly decreased PmB and increased αB values, and increased CO2 concentrations resulted in significantly increased PmB and αB values. Comparison of photosynthetic parameters derived at stations where iron concentrations were above and below 0.1 nM indicated that reduced iron levels were associated with significantly increased PmB values, confirming the importance of iron within the photosynthetic process. No significant difference was detected between stations dominated by diatoms and those dominated by the haptophyte Phaeocystis antarctica. The meta-analysis confirms the photosynthetic rates predicted from global analyses that are based solely on temperature and irradiance availability, but suggests that, for more accurate predictions of productivity in polar systems, a more detailed model that includes temporal effects of photosynthetic parameters will be required.
Inhibition of gap junction and adherens junction assembly by connexin and A-CAM antibodies

We examined the roles of the extracellular domains of a gap junction protein and a cell adhesion molecule in gap junction and adherens junction formation by altering cell interactions with antibody Fab fragments. Using immunoblotting and immunocytochemistry we demonstrated that Novikoff cells contained the gap junction protein, connexin43 (Cx43), and the cell adhesion molecule, A-CAM (N-cadherin). Cells were dissociated in EDTA, allowed to recover, and reaggregated for 60 min in media containing Fab fragments prepared from a number of antibodies. We observed no cell-cell dye transfer 4 min after microinjection in 90% of the cell pairs treated with Fab fragments of antibodies for the first or second extracellular domain of Cx43, the second extracellular domain of connexin32 (Cx32) or A-CAM. Cell-cell dye transfer was detected within 30 s in cell pairs treated with control Fab fragments (pre- immune serum, antibodies to the rat major histocompatibility complex or the amino or carboxyl termii of Cx43). We observed no gap junctions by freeze-fracture EM and no adherens junctions by thin section EM between cells treated with the Fab fragments that blocked cell-cell dye transfer. Gap junctions were found on approximately 50% of the cells in control samples using freeze-fracture EM. We demonstrated with reaggregated Novikoff cells that: (a) functional interactions of the extracellular domains of the connexins were necessary for the formation of gap junction channels; (b) cell interactions mediated by A-CAM were required for gap junction assembly; and (c) Fab fragments of antibodies for A-CAM or connexin extracellular domains blocked adherens junction formation.
Comparison of SefA, FimA and AgfA fimbrial proteins of Salmonella enteritidis in their abilities to elicit humoral immune response in hens

Immunization of hens with SefA and FimA fimbrial proteins of Salmonella Enteritidis induces strong humoral response as it was shown by ELISA assay. The levels of anti-SefA and anti-FimA antibodies induced by purified recombinant proteins are similar to that obtained with live bacteria. SefA and FimA can be obtained with high purity and yield as recombinant proteins expressed in E. coli. For these reasons they can be considered as components of subunit vaccine. From the other hand, low immunogenicity of AgfA excluded this protein as a constituent of such vaccine.
Chandra X-Ray Observation of the Orion Nebula Cluster. I. Detection, Identification, and Determination of X-Ray Luminosities

In this first of two companion papers on the Orion Nebula Cluster (ONC), we present our analysis of a 63 ks Chandra HRC-I observation that yielded 742 X-ray detections within the 30′ × 30′ field of view. To facilitate our interpretation of the X-ray image, here we collect a multiwavelength catalog of nearly 2900 known objects in the region by combining 17 different catalogs from the recent literature. We define two reference groups: an infrared sample, containing all objects detected in the K band, and an optical sample comprising low-extinction, well-characterized ONC members. We show for both samples that field object contamination is generally low. Our X-ray sources are primarily low-mass ONC members. The detection rate for optical sample stars increases monotonically with stellar mass from zero at the brown dwarf limit to ~100% for the most massive stars but shows a pronounced dip between 2 and 10 M☉. We determine LX and LX/Lbol for all stars in our optical sample and utilize this information in our companion paper to study correlations between X-ray activity and other stellar parameters.
Effect of Yogic Breathing Techniques in New Sputum Positive Pulmonary Tuberculosis

A 24-year-old, unmarried woman diagnosed of pulmonary tuberculosis (PTB) visited our hospital out-patient department in the month of August-2013. Patient came with the complaint of sever cough with expectoration; evening raise of temperature; gradual loss of appetite and weight since 2-weeks. We referred the patient to our hospital's Revised National Tuberculosis Program, direct observed treatment short-course center for sputum fluorescence microscopic examination (FME). FME report suggested the new smear positive, 2+ PTB. Our patient received yogic breathing techniques (YBT) for 45-min daily under the supervision for three alternate-days/week with anti-tuberculosis treatment (ATT) for the period of 8-weeks. After intervention our result showed better improvement in weight gain, body mass index, symptom scores, pulmonary function and health related quality of life with conversion of positive to negative FME for acid fast bacilli. It suggests YBT with ATT are effective in treating PTB and further studies required to warrant this effect.
TLR4-Activated MAPK-IL-6 Axis Regulates Vascular Smooth Muscle Cell Function

Migration of vascular smooth muscle cells (VSMCs) into the intima is considered to be a vital event in the pathophysiology of atherosclerosis. Despite substantial evidence supporting the pathogenic role of Toll-like receptor 4 (TLR4) in the progression of atherogenesis, its function in the regulation of VSMC migration remains unclear. The goal of the present study was to elucidate the mechanism by which TLR4 regulates VSMC migration. Inhibitor experiments revealed that TLR4-induced IL-6 secretion and VSMC migration were mediated via the concerted actions of MyD88 and TRIF on the activation of p38 MAPK and ERK1/2 signaling. Neutralizing anti-IL-6 antibodies abrogated TLR4-driven VSMC migration and F-actin polymerization. Blockade of p38 MAPK or ERK1/2 signaling cascade inhibited TLR4 agonist-mediated activation of cAMP response element binding protein (CREB). Moreover, siRNA-mediated suppression of CREB production repressed TLR4-induced IL-6 production and VSMC migration. Rac-1 inhibitor suppressed TLR4-driven VSMC migration but not IL-6 production. Importantly, the serum level of IL-6 and TLR4 endogenous ligand HMGB1 was significantly higher in patients with coronary artery diseases (CAD) than in healthy subjects. Serum HMGB1 level was positively correlated with serum IL-6 level in CAD patients. The expression of both HMGB1 and IL-6 was clearly detected in the atherosclerotic tissue of the CAD patients. Additionally, there was a positive association between p-CREB and HMGB1 in mouse atherosclerotic tissue. Based on our findings, we concluded that, upon ligand binding, TLR4 activates p38 MAPK and ERK1/2 signaling through MyD88 and TRIF in VSMCs. These signaling pathways subsequently coordinate an additive augmentation of CREB-driven IL-6 production, which in turn triggers Rac-1-mediated actin cytoskeleton to promote VSMC migration.
Longitudinal decline of leukocyte telomere length in old age and the association with sex and genetic risk

Telomeres are DNA-protein structures at the ends of chromosomes. Leukocyte telomere length (LTL) shortening has been associated with advanced age. However, most studies use cross-sectional data, hence, the aim of our study was to model longitudinal trajectories of LTL attrition across 20 years at old age. Assessments of LTL were done by qPCR in SATSA (Swedish Adoption/Twin Study of Aging; N=636 individuals). Cross-sectional and longitudinal associations with age were estimated, the latter using latent growth curve analysis. A genetic risk score (GRS) for LTL was further assessed and included in the models. We confirmed an inverse cross-sectional association of LTL with age (B=−0.0022 T/S-ratio; 95% CI: −0.0035, −0.0009, p-value=0.0008). Longitudinal LTL analyses adjusted for sex (1598 samples; ≤5 measurements) suggested modest average decline until 69 years of age but accelerating decline after 69 years, with significant inter-individual variation. Women had on average ∼6% T/S-ratio units longer LTL at baseline, and inclusion of the GRS improved the model where four risk alleles was equivalent to the effect size difference between the sexes. In this cohort of old individuals, baseline LTL varied with age, sex and genetic background. The rate of change of LTL accelerated with age and varied considerably between individuals.
Time-critical integration of formants for perception of communication calls in mice

Brain mechanisms in humans group together acoustical frequency components both in the spectral and temporal domain, which leads to the perception of auditory objects and of streams of sound events that are of biological and communicative significance. At the perceptual level, behavioral data on mammals that clearly support the presence of common concepts for processing species-specific communication sounds are unavailable. Here, we synthesize 17 models of mouse pup wriggling calls, present them in sequences of four calls to the pups' mothers in a natural communication situation, and record the maternal response behavior. We show that the biological significance of a call sequence depends on grouping together three predominant frequency components (formants) to an acoustic object within a critical time window of about 30-ms lead or lag time of the first formant. Longer lead or lag times significantly reduce the maternal responsiveness. Central inhibition seems to be responsible for setting this time window, which is also found in numerous perceptual studies in humans. Further, a minimum of 100-ms simultaneous presence of the three formants is necessary for occurrence of response behavior. As in humans, onset-time asynchronies of formants and formant durations interact nonlinearly to influence the adequate perception of a stream of sounds. Together, these data point to common rules for time-critical spectral integration, perception of acoustical objects, and auditory streaming (perception of an acoustical Gestalt) in mice and humans.
An ethnography of a children's renal unit: experiences of children and young people with long-term renal illness.

AIM This study explored the experience of long-term renal illness, including issues concerning compliance with treatment, from the perspectives of children and young people. BACKGROUND Children and young people have difficulty complying with renal treatment; research in this area usually focuses on their compliance with a narrow range of behaviours: compliance with dialysis, tablet taking and dietary and fluid restrictions. Renal compliance studies are usually premised on the assumption that children will automatically comply with treatment and/or that blame for non-compliance rests with the child and family. DESIGN The study, underpinned by a view of children as competent social agents, used ethnography to explore and describe the everyday experience of long-term renal illness. METHOD Ethnographic fieldwork--involving participant observation, informal interviews and the use of children's drawings--took place over 16 months in a hospital renal unit comprising an inpatient ward, a haemodialysis unit and an outpatient clinic. The primary participants were 13 children; 14 carers and 36 staff members also participated. Data were interrogated through descriptive and thematic forms of analysis. RESULTS This study reveals participants' perspectives on the physical and social impact of renal treatment. It also provides a conceptualisation of life with long-term renal illness that highlights children's management of 'illness labour', their inhabitation 'renal geographical space', 'a renal body' and a 'renal social world'. CONCLUSIONS These findings show how compliance with renal treatment involves particular embodied experiences that are hard for children to manage. Traditional views of compliance/non-compliance render children's embodied experience and their labour in managing dialysis, thirst and their difficulties with tablet taking irrelevant, whilst this study shows these as highly relevant to children. RELEVANCE TO CLINICAL PRACTICE The conceptualisation of children's experience arising in this study provides a new way of considering the embodied experience of children with long-term renal illness.
Uncovering archaeological landscapes at Angkor using lidar

Previous archaeological mapping work on the successive medieval capitals of the Khmer Empire located at Angkor, in northwest Cambodia (∼9th to 15th centuries in the Common Era, C.E.), has identified it as the largest settlement complex of the preindustrial world, and yet crucial areas have remained unmapped, in particular the ceremonial centers and their surroundings, where dense forest obscures the traces of the civilization that typically remain in evidence in surface topography. Here we describe the use of airborne laser scanning (lidar) technology to create high-precision digital elevation models of the ground surface beneath the vegetation cover. We identify an entire, previously undocumented, formally planned urban landscape into which the major temples such as Angkor Wat were integrated. Beyond these newly identified urban landscapes, the lidar data reveal anthropogenic changes to the landscape on a vast scale and lend further weight to an emerging consensus that infrastructural complexity, unsustainable modes of subsistence, and climate variation were crucial factors in the decline of the classical Khmer civilization.
Quickest search over multiple sequences with mixed observations

The problem of sequentially finding an independent and identically distributed (i.i.d.) sequence that is drawn from a probability distribution F1 by searching over multiple sequences, some of which are drawn from F1 and the others of which are drawn from a different distribution F0, is considered. The sensor is allowed to take one observation at a time. It has been shown in a recent work that if each observation comes from one sequence, Cumulative Sum (CUSUM) test is optimal. In this paper, we propose a new approach in which each observation can be a linear combination of samples from multiple sequences. The test has two stages. In the first stage, namely scanning stage, one takes a linear combination of a pair of sequences with the hope of scanning through sequences that are unlikely to be generated from F1 and quickly identifying a pair of sequences such that at least one of them is highly likely to be generated by F1. In the second stage, namely refinement stage, one examines the pair identified from the first stage more closely and picks one sequence to be the final sequence. The problem under this setup belongs to a class of multiple stopping time problems. In particular, it is an ordered two concatenated Markov stopping time problem. We obtain the optimal solution using the tools from the multiple stopping time theory. Numerical simulation results show that this search strategy can significantly reduce the searching time, especially when F1 is rare.
Approximate analytical solutions of Newell-Whitehead-Segel equation using a new iterative method

The Newell-Whitehead-Segel equation is an important model arising in fluid mechanics. Various researchers worked on approximate solution of this model by using different methods. In this paper, we use New Iterative Method (NIM) proposed by Daftardar-Gejji and Jafari for the same purpose. We use software Mathematica 10 for computations. The results obtained by NIM are compared with exact solutions and those obtained by other iterative methods such as Laplace Adomian decomposition method (LADM) and Adomian decomposition method (ADM). It is observed that NIM is simple as compared with other methods. The solutions obtained using NIM are in well agreement with exact solution and permit very less error.
Dimethylsulphoniopropionate (DMSP) as an Indicator of Bleaching Tolerance in Scleractinian Corals

Thermal tolerance tests on Acropora millepora, a common Indo-Pacific hard coral, have shown that adult corals can acquire increased thermal tolerance by shuffling existing type C to type D Symbiodinium zooxanthellae when subjected to increased seawater temperatures. We report here dimethylsulphoniopropionate (DMSP) concentrations in A. millepora and examine links between DMSP concentrations, zooxanthellae clade, and bleaching tolerance. DMSP analysis on native and transplanted corals from three locations in the Great Barrier Reef indicated that the lower thermal tolerance in type C zooxanthellae coincided with variable DMSP concentrations, whilst the more thermal tolerant type D zooxanthellae had more stable areal DMSP concentrations as seawater temperatures increased. Our results suggest this increased thermal tolerance in type D zooxanthellae may reflect the ability of these coral symbionts to conserve their antioxidant DMSP levels to relatively constant concentrations, enabling the coral to overcome the build-up of oxygen free radicals in the cytoplasm of A. millepora. A conceptual diagram illustrates how the antioxidants DMS (P) participate in the bleaching process by scavenging oxygen free radicals and form DMSO, thus moderating coral bleaching and increasing thermotolerance.
Prevention of tuberculosis in older adults in the United States: obstacles and opportunities.

BACKGROUND Persons ≥65 are a growing proportion of the US population and are at increased risk for tuberculosis disease. The objective of the study was to examine rates and identify risk factors for tuberculosis among older adults in the United States. METHODS Average rates and rate ratios for tuberculosis by age group, race/ethnicity, country of birth, calendar year, and long-term care facility residence were calculated using Centers for Disease Control and Prevention tuberculosis case reports and Census Bureau data. RESULTS Older adults accounted for 21.9% of tuberculosis cases in the United States between 1993 and 2008. Average yearly tuberculosis rates over sixteen years were 10.9 per 100 000 (95% confidence interval [CI], 10.8-11.0) in older adults compared with 7.3 per 100 000 (95% CI, 7.3-7.4) in persons aged 21-64 (rate ratio [RR], 1.5; 95% CI, 1.5-1.5). Among older adults, tuberculosis rates increased with age from 9.6 per 100 000 in persons aged 65-74 to 14.2 per 100 000 in persons aged ≥85 years. Older persons at higher risk for tuberculosis include men (RR, 2.1; 95% CI, 2.1-2.2), American Indians/Alaska Natives (RR 3.6; 95% CI, 3.4-3.9), those in long-term care facilities (RR 2.3; 95% CI, 2.2-2.3), and the foreign-born (RR 5.1; 95% CI, 5.0-5.2). CONCLUSIONS Elimination of tuberculosis in the United States will require addressing the substantial burden of disease among older persons, especially men, non-whites, long-term care facility residents, and foreign-born persons. Use of interferon-γ release assay testing may help prioritize persons with greatest need for treatment of latent tuberculosis infection, as new shorter and less toxic regimens make latent tuberculosis treatment in older adults more attractive.