Miracle-dz/UniFAR-FTUs huggingface dataset:
An enhanced particle filtering method for GMTI radar tracking

This paper investigates the problem of ground vehicle tracking with ground-moving target indicator (GMTI) radar. In practice, the movement of ground vehicles may involve several different maneuvering types (acceleration, deceleration, standstill, etc.). Consequently, the GMTI radar may lose measurements when the radial velocity of the ground vehicle is below a threshold, i.e., falling into the Doppler blind region. In this paper, to incorporate the information gathered from normal measurements and knowledge on the Doppler blindness constraint, we develop an enhanced particle filtering method for which the importance distributions are inspired by a recent noise-related Doppler blind (NRDB) filtering algorithm for GMTI tracking. Specifically, when constructing the importance distributions, the proposed particle filter takes the advantages of the efficient NRDB algorithm by applying the extended Kalman filter and its generalization for interval-censored measurements. In addition, the linearization and Gaussian approximations in the NRDB algorithm are corrected by the weighting process of the developed filtering method to achieve a more accurate GMTI tracking performance. The simulation results show that the proposed method substantially outperforms the existing methods for the GMTI tracking problem.
Some Results Concerning Generalized Bent Functions

In this paper we investigate the properties of generalized bent functions defined on Z2 with values in Zq where q ≥ 2 is any positive integer. We characterize the class of generalized bent functions symmetric with respect to two variables, provide an analogue of Maiorana– McFarland type bent functions in the generalized set up. A class of bent functions called generalized spreads type is introduced and it is demonstrated that recently introduced Dillon type generalized bent functions and Maiorana–McFarland type generalized bent functions can be described as generalized spreads type functions. Thus unification of two different types of generalized bent functions is achieved.
School‐based curriculum development: the Hong Kong experience

ABSTRACT The purpose of this article is to analyse the nature of the School‐based Curriculum Project Scheme (SBCPS), which was introduced into the Hong Kong education system in 1988. The aims of the scheme were to promote school‐based curriculum development (SBCD) designed to meet the learning needs of pupils and to encourage teachers to solve curriculum problems. Overall, the article provides insights into the characteristics of the SBCPS which was introduced into a highly centralized context and was initiated through a highly centralized mechanism, and describes how it was implemented into Hong Kong schools. This underlines the need both to view curriculum policies critically and to recognize the impact that the prevailing culture in schools has on attempts at curriculum innovations.
Salt Bridges in the Hyperthermophilic Protein Ssh10b Are Resilient to Temperature Increases*

A double mutant cycle (DMC) approach was employed to estimate the effect of temperature on the contribution of two highly conserved salt bridges to protein stability in the hyperthermophilic protein Ssh10b. The coupling free energy were 2.4 ± 0.4 kJ/mol at 298 K and 2.2 ± 0.4 kJ/mol at 353 K for Glu-54/Arg-57, and 6.0 ± 0.2 kJ/mol at 298 K and 5.9 ± 0.6 kJ/mol at 353 K for Glu-36/Lys-68. The stability free energy of Ssh10b decrease greatly with increasing temperature, while the direct contribution of these two salt bridges to protein stability remain almost constant, providing evidence supporting the theoretical prediction that salt bridges are extremely resilient to temperature increases and thus are specially suited to improving protein stability at high temperatures. The reason for the difference in coupling free energy between salt bridges Glu-54/Arg-57 and Glu-36/Lys-68 is discussed. Comparing our results with published DMC data for the contribution of salt bridges to stability in other proteins, we found that the energy contribution of a salt bridge formed by two charged residues far apart in the primary sequence is higher than that of those formed between two very close ones. Implications of this finding are useful for engineering proteins with enhanced thermostability.
Trichobezoar obstruction after stapled jejunal anastomosis in a dog.

OBJECTIVE To describe an unusual long-term complication of circular end-to-end anastomosis (CEEA) stapling in a dog. STUDY DESIGN Clinical case report. ANIMAL An 11-year-old, female neutered, Labrador Retriever. METHODS The dog was referred for clinical signs of bowel obstruction. An enterectomy was performed 2 years before presentation using a CEEA stapling device. Palpation, plain radiographs, and ultrasound of the abdomen confirmed the presence of a mass in the bowel, causing obstruction, and requiring surgical approach. RESULTS An exploratory celiotomy revealed a 5 cm mass in the jejunum, involving the site of the previous surgery. The mass was removed by enterectomy. Dissection of the mass revealed the presence of many staples at the previous enterectomy site, and a trichobezoar entangled in the exposed parts of the staples. CONCLUSIONS An enterectomy was required to treat an intestinal obstruction caused by a trichobezoar entangled in a CEEA-stapled anastomosis. CLINICAL RELEVANCE Development of trichobezoar and subsequent bowel obstruction should be considered an unusual but potential long-term complication of CEEA-stapled anastomosis.
Piperlongumine selectively kills hepatocellular carcinoma cells and preferentially inhibits their invasion via ROS-ER-MAPKs-CHOP

Hepatocellular carcinomas (HCC) are highly malignant and aggressive tumors lack of effective therapeutic drugs. Piperlongumine (PL), a natural product isolated from longer pepper plants, is recently identified as a potent cytotoxic compound highly selective to cancer cells. Here, we reported that PL specifically suppressed HCC cell migration/invasion via endoplasmic reticulum (ER)-MAPKs-CHOP signaling pathway. PL selectively killed HCC cells but not normal hepatocytes with an IC50 of 10-20 μM while PL at much lower concentrations only suppressed HCC cell migration/invasion. PL selectively elevated reactive oxygen species (ROS) in HCC cells, which activated or up-regulated downstream PERK/Ire 1α/Grp78, p38/JNK/Erk and CHOP subsequently. Administration of antioxidants completely abolished PL's effects on cell death and migration/invasion. However, pharmacological inhibition of ER stress-responses or MAPKs signaling pathways with corresponding specific inhibitors only reversed PL's effect on cell migration/invasion but not on cell death. Consistently, knocking-down of CHOP by RNA interference only reversed PL-suppressed HCC cell migration. Finally, PL significantly suppressed HCC development and activated the ER-MAPKs-CHOP signaling pathway in HCC xenografts in vivo. Taken together, PL selectively killed HCC cells and preferentially inhibited HCC cell migration/invasion via ROS-ER-MAPKs-CHOP axis, suggesting a novel therapeutic strategy for the highly malignant and aggressive HCC clinically.
Mechanisms that determine plasma cell lifespan and the duration of humoral immunity

Summary: Humoral immunity following vaccination or infection is mainly derived from two types of cells: memory B cells and plasma cells. Memory B cells do not actively secrete antibody but instead maintain their immunoglobulin in the membrane‐bound form that serves as the antigen‐specific B‐cell receptor. In contrast, plasma cells are terminally differentiated cells that no longer express surface‐bound immunoglobulin but continuously secrete antibody without requiring further antigenic stimulation. Pre‐existing serum or mucosal antibody elicited by plasma cells (or other intermediate antibody‐secreting cells) represents the first line of defense against reinfection and is critical for protection against many microbial diseases. However, the mechanisms involved with maintaining long‐term antibody production are not fully understood. Here, we examine several models of long‐term humoral immunity and present a new model, described as the ‘Imprinted Lifespan’ model of plasma cell longevity. The foundation of this model is that plasma cells are imprinted with a predetermined lifespan based on the magnitude of B‐cell signaling that occurs during the induction of an antigen‐specific humoral immune response. This represents a testable hypothesis and may explain why some antigen‐specific antibody responses fade over time whereas others are maintained essentially for life.
Improving learning of computational thinking using creative thinking exercises in CS-1 computer science courses

Promoting computational thinking is one of the top priorities in CS education as well as in other STEM and non-STEM disciplines. Our innovative NSF-funded IC2Think project blends computational thinking with creative thinking so that students leverage their creative thinking skills to “unlock” their understanding of computational thinking. In Fall 2012, we deployed creative exercises designed to engage Epstein's creative competencies (Surrounding, Capturing, Challenging and Broadening) in introductory level CS courses targeting four different groups (CS, engineering, combined CS/physical sciences, and humanities majors). Students combined hands-on problem solving with guided analysis and reflection to connect their creative activities to CS topics such as conditionals and arrays and to real-world CS applications. Evaluation results (approximately 150 students) found that creative thinking exercise completion had a linear “dosage” effect. As students completed more exercises [0/1 - 4], they increased their long-term retention [a computational thinking test], F(3, 98) = 4.76, p =. 004, partial Eta2 = . 127 and course grades, F(3, 109) = 4.32, p =. 006, partial Eta2 = . 106. These findings support our belief that the addition of creative thinking exercises to CSCE courses improves the learning of computational knowledge and skills.
Use of the Strengths and Difficulties Questionnaire to assess the mental health needs of children and adolescents with intellectual disabilities

Background Over the last decade increased attention has been paid to identifying and responding to the mental health needs of children and adolescents with intellectual disabilities. There is, however, little information available on the use of self‐report scales by young people with intellectual disabilities. This study sought to determine the reliability and validity of the child, carer and teacher versions of the extended Strength and Difficulties Questionnaire (SDQ) when used with this population. Method Secondary analysis was undertaken of a nationally representative survey of the mental health of 4,449 children between 11 and 15 years of age in Great Britain. Data were extracted on an operationally defined sub‐sample of 98 children with intellectual disabilities, and on 4,074 children without intellectual disabilities. Results All scales on the SDQ proved to be internally consistent. Acceptable levels of validity were found by examining: (1) correspondence between parallel child, carer and teacher versions of the SDQ; (2) association between SDQ scores and ICD‐10 diagnoses. Conclusion The extended SDQ appears to provide a simple robust measure of the mental health needs of children and adolescents with intellectual disabilities.
Clinical features of human influenza A (H5N1) infection in Vietnam: 2004-2006.

BACKGROUND The first cases of avian influenza A (H5N1) in humans in Vietnam were detected in early 2004, and Vietnam has reported the second highest number of cases globally. METHODS We obtained retrospective clinical data through review of medical records for laboratory confirmed cases of influenza A (H5N1) infection diagnosed in Vietnam from January 2004 through December 2006. Standard data was abstracted regarding clinical and laboratory features, treatment, and outcome. RESULTS Data were obtained for 67 (72%) of 93 cases diagnosed in Vietnam over the study period. Patients presented to the hospital after a median duration of illness of 6 days with fever (75%), cough (89%), and dyspnea (81%). Diarrhea and mucosal bleeding at presentation were more common in fatal than in nonfatal cases. Common findings were bilateral pulmonary infiltrates on chest radiograph (72%), lymphopenia (73%), and increased serum transaminase levels (aspartate aminotransferase, 69%; alanine aminotransferase, 61%). Twenty-six patients died (case fatality rate, 39%; 95% confidence interval, 27%-51%) and the most reliable predictor of a fatal outcome was the presence of both neutropenia and raised alanine aminotransferase level at admission, which correctly predicted 91% of deaths and 82% of survivals. The risk of death was higher among persons aged < or =16 years, compared with older persons (P < .001), and the risk of death was higher among patients who did not receive oseltamivir treatment (P = .048). The benefit of oseltamivir treatment remained after controlling for potential confounding by 1 measure of severity (odds ratio, 0.15; 95% confidence interval, 0.026-0.893; P = .034). CONCLUSION In cases of infection with Influenza A (H5N1), the presence of both neutropenia and raised serum transaminase levels predicts a poor outcome. Oseltamivir treatment shows benefit, but treatment with corticosteroids is associated with an increased risk of death.
In Defence of Sartori

In a recent re-evaluation of developments in European party systems, Paul Pennings has criticized Sartori for inaccurately predicting trends in party competition in his original typology, particularly as evidenced by indicators such as ideological polarization, electoral volatility and systemic stability. In this article I argue that many of these criticisms are unfounded as, firstly, they misinterpret Sartori's assumptions and predictions; and secondly, they employ invalid indicators to measure such party system traits. Furthermore, whilst the polarized pluralist type in particular needs clarification in many respects, focusing on voter preference distributions reveals that the fundamental arguments about the direction of competition are correct. I conclude that if a better understanding of contemporary party systems is to be reached, greater attention needs to be given to electoral demand and its interaction with party supply whilst retaining the principal features of Sartori's model.
Oral health-related quality of life and periodontal health status in patients undergoing hemodialysis.

BACKGROUND Health-related quality of life (HRQOL) is a multidimensional concept regarding quality of life (QOL) as it relates specifically to health and disease. The effect of ongoing hemodialysis on a person's oral health can be determined by clinical variables, but these do not reflect the person's perception of health versus illness. The authors conducted a study to determine the periodontal status, attitude toward oral health and self-perceived oral health in patients undergoing hemodialysis, as well as to evaluate the effect of oral health on QOL within this group. METHODS Patients undergoing hemodialysis were evaluated for socio-demographic and periodontal variables. The authors evaluated oral health-related quality of life (OHRQOL) by means of the short-form Oral Health Impact Profile (OHIP-14) and the General Oral Health Assessment Index (GOHAI). They measured perceived oral health by asking a single question. RESULTS The study involved 47 patients undergoing hemodialysis. Plaque index score, gingival index score, probing depth and bleeding-on-probing status were 2.21 +/- 0.66, 1.24 +/- 0.77, 2.17 millimeters +/- 0.53 mm and 33.51 percent +/- 24.58 percent, respectively. Participants reported being uncomfortable when eating or swallowing. Participants reported being sensitive to hot or cold (69.8 percent), having a worse sense of taste (90.8 percent) and having painful aching in the mouth (72.1 percent). The mean OHIP-14 and GOHAI scores were 19.40 +/- 7.74 and 15.72 +/- 8.68, respectively. CONCLUSIONS The self-perceived health of 72.7 percent of participants undergoing hemodialysis was fair or poor, and the impact of OHRQOL was moderate, which means that oral health was not a major concern. These results underscore the importance of using subjective and self-reported oral assessments to determine more convenient and satisfying treatment approaches for each patient. CLINICAL IMPLICATIONS Clinicians should use oral health assessment tools to determine individual treatment and approaches to promote the oral health of patients undergoing hemodialysis and improve their QOL.
A study of colour emotion and colour preference. Part I: Colour emotions for single colours

This article classifies colour emotions for single colours and develops colour-science-based colour emotion models. In a psychophysical experiment, 31 observers, including 14 British and 17 Chinese subjects assessed 20 colours on 10 colour-emotion scales: warm–cool, heavy–light, modern–classical, clean–dirty, active–passive, hard–soft, tense–relaxed, fresh–stale, masculine–feminine, and like–dislike. Experimental results show no significant difference between male and female data, whereas different results were found between British and Chinese observers for the tense–relaxed and like–dislike scales. The factor analysis identified three colour-emotion factors: colour activity, colour weight, and colour heat. The three factors agreed well with those found by Kobayashi and Sato et al. Four colour-emotion models were developed, including warm–cool, heavy–light, active–passive, and hard–soft. These models were compared with those developed by Sato et al. and Xin and Cheng. The results show that for each colour emotion the models of the three studies agreed with each other, suggesting that the four colour emotions are culture-independent across countries. © 2004 Wiley Periodicals, Inc. Col Res Appl, 29, 232–240, 2004; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/col.20010
The Mycobacterium tuberculosis stress response factor SigH is required for bacterial burden as well as immunopathology in primate lungs.

BACKGROUND Sigma H (sigH) is a major Mycobacterium tuberculosis (Mtb) stress response factor. It is induced in response to heat, oxidative stress, cell wall damage, and hypoxia. Infection of macrophages with the Δ-sigH mutant generates more potent innate immune response than does infection with Mtb. The mutant is attenuated for pathology in mice. METHODS We used a nonhuman primate (NHP) model of acute tuberculosis, to better understand the phenotype of the Δ-sigH mutant in vivo. NHPs were infected with high doses of Mtb or the mutant, and the progression of tuberculosis was analyzed in both groups using clinical, pathological, microbiological, and immunological parameters. RESULTS Animals exposed to Mtb rapidly progressed to acute pulmonary tuberculosis as indicated by worsening clinical correlates, high lung bacterial burden, and granulomatous immunopathology. All the animals rapidly succumbed to tuberculosis. On the other hand, the NHPs exposed to the Mtb:Δ-sigH mutant did not exhibit acute tuberculosis, instead showing significantly blunted disease. These NHPs survived the entire duration of the study. CONCLUSIONS The Mtb:Δ-sigH mutant is completely attenuated for bacterial burden as well as immunopathology in NHPs. SigH and its regulon are required for complete virulence in primates. Further studies are needed to identify the molecular mechanism of this attenuation.
Unresolved trauma in mothers: intergenerational effects and the role of reorganization

A mother's unresolved trauma may interfere with her ability to sensitively respond to her infant, thus affecting the development of attachment in her own child, and potentially contributing to the intergenerational transmission of trauma. One novel construct within the Dynamic Maturational Model of Attachment and Adaptation (DMM) coding of the Adult Attachment Interview (AAI) is “reorganization,” a process whereby speakers are actively changing their understanding of past and present experiences and moving toward attachment security. We conducted a study of mothers with unresolved trauma, exploring their own attachment classification, attachment outcomes of their children, and the potential effects of reorganization on child attachment. Forty-seven first-time mothers participated in the AAI during pregnancy, and returned with their child at 11 months to assess child attachment using the Strange Situation Procedure. Mothers with and without unresolved trauma were compared. We found that mothers with unresolved trauma had insecure attachment themselves and were more likely to have infants with insecure attachment. However, the one exception was that all of the mothers with unresolved trauma who were reorganizing toward secure attachment had infants with secure attachment. These preliminary findings suggest that mothers who are reorganizing may be able to more sensitively respond to their child's cues, contributing to the development of secure attachment. While our results need to be replicated in a larger cohort, this study is the first to explore the construct of reorganization and its potential relationship with child attachment. If confirmed in future studies, it may provide clinical insight into the intergenerational transmission of insecure attachment within the context of unresolved trauma.
Topology detection in microgrids with micro-synchrophasors

Network topology in distribution networks is often unknown, because most switches are not equipped with measurement devices and communication links. However, knowledge about the actual topology is critical for safe and reliable grid operation. This paper proposes a voting-based topology detection method based on micro-synchrophasor measurements. The minimal difference between measured and calculated voltage angle or voltage magnitude, respectively, indicates the actual topology. Micro-synchrophasors or micro-Phasor Measurement Units (μPMU) are high-precision devices that can measure voltage angle differences on the order of ten millidegrees. This accuracy is important for distribution networks due to the smaller angle differences as compared to transmission networks. For this paper, a microgrid test bed is implemented in MATLAB with simulated measurements from μPMUs as well as SCADA measurement devices. The results show that topologies can be detected with high accuracy. Additionally, topology detection by voltage angle shows better results than detection by voltage magnitude.