Miracle-dz/UniFAR-FTUs huggingface dataset:
Stent placement prior to initiation of chemotherapy in patients with obstructive, nonoperative left sided tumors is associated with fewer stomas

Due to the potential risks associated with stent placement, European Society Gastrointestinal Endoscopy does not recommend prophylactic insertion of stents in patients without symptoms. The aim was to compare complication rates, need of surgery, colostomy formation, and survival between stent placement prior to start of chemotherapy (SEMS group) and upfront ChT (ChT group) in patients with endoscopically non‐transverable metastatic left‐sided colorectal cancer.
Fine-Scale Biogeographical Boundary Delineation and Sub-population Resolution in the Symbiodinium thermophilum Coral Symbiont Group From the Persian/Arabian Gulf and Gulf of Oman

The adaptation of tropical coral communities to the world’s hottest sea, the Persian / Arabian Gulf (PAG), has recently been associated with ecological selection acting on a group of coral-associated algal symbionts, the Symbiodinium thermophilum group. Previous studies have shown that considerable genetic diversity exists within the group and that group members found within the PAG are significantly differentiated from those found externally, in the Gulf of Oman and wider waters. However, little is known about this genetic diversity. As an initial step towards understanding whether this diversity could represent niche adapted, selectable populations within the S. thermophilum group that may act as natural sources of stress tolerant associations to Indo-Pacific reefs, we investigate whether the diversity is structured between populations and where the location of the internal-external genetic partition lies. We use regions of the nuclear ribosomal DNA (ITS1-5.8S-ITS2) and chloroplastic psbA gene (non-coding region) from > 100 S. thermophilum group-harbouring Porites spp. (P. lobata, P. lutea and P. harrisoni) sampled across steep temperature and salinity gradients to conduct analyses of variance and create maximum parsimony networks to assess genetic structure and (dis)similarity within and between populations of S. thermophilum found within the PAG and externally in the Gulf of Oman. Our analyses resolve a sharp genetic boundary between Symbiodinium populations in the western Strait of Hormuz and identify significant genetic structure between populations with as little as 20km between them demonstrating that differentiation between populations is likely due to factors other than limited connectivity. Further, we hypothesize that genotypes identified outside of the PAG in the Gulf of Oman existing in near-oceanic salinities, yet thermally challenging waters, putatively represent candidates for stress-tolerant symbionts that could act as natural seed populations of stress tolerant genotypes to the wider indo-Pacific.
Fracture Behavior of Nanoscale Notched Silicon Beams Investigated by the Theory of Critical Distances

This paper investigates the nanoscale fracture behavior of silicon using the Theory of Critical Distances (TCD) and demonstrates that TCD can correctly estimate the magnitude of the breakdown of continuum fracture mechanics. Moreover, it proposes the TCD as an alternative strategy for the determination of fracture toughness, KIC, at the nanoscale. More specifically, in situ micromechanical testing of notched nano‐cantilever beams has been carried out in a transmission electron microscope. The material characteristic length and fracture toughness are then evaluated. The average KIC value obtained is 0.98 MPa m0.5, which is in agreement with that reported in the literature for macro‐Si. The characteristic length L is in the range of 1.3–1.9 nm. It is found that within an atomistic interpretation of the fracture of silicon, these values are in agreement with the breakdown of continuum fracture mechanics.
Sexing free-ranging adult Cuvier’s beaked whales ( Ziphius cavirostris ) using natural marking thresholds and pigmentation patterns

Sex identification of adult cetaceans is an important ecological parameter that should be incorporated into studies such as population dynamics and animal behavior. In Cuvier's beaked whale (Ziphius cavirostris), sex determination may be achieved through genetics, observation of genitals, the presence/absence of erupted teeth, and calf association. However, these features are difficult to ascertain due to the shy behavior of this species. Therefore, this study aimed to create a robust sex identification method using only external characteristics. Particularly, this work analyzed pigmentation patterns and levels of natural marks from adult individuals of known sex in order to identify gender differences, using frequency analysis and generalized linear models. Photographic captures of 73 free-ranging animals were utilized. The frequencies of the individual pigmentation patterns were found to be sex dependent. The 63% of the animals could be classified into either a “soft” or “sharp” pigmentation cluster. The “soft” cluster was only displayed by females, while the “sharp” cluster was present in both the sexes. However, the model selection process indicated that natural marking is the best determinative factor for sex classification. The density of the visible intraspecific natural marks was found to differ between the sexes (P value < 0.001) and was incorporated as a predictor variable into several candidate models. All candidate models had a high predictive power (mean area under the curve 0.973) and correctly predicted the sex, by means of a density threshold value, in 85–90% of the analyzed animals. The density threshold ranged from 4.1% to 6.4% according to the different body area analyzed. These density threshold values represent a robust post hoc sexing method to classify individuals to sex from opportunistic photos in the absence of other sexing methods.
A Large-Scale Study of iPhone App Launch Behaviour

There have been many large-scale investigations of users' mobile app launch behaviour, but all have been conducted on Android, even though recent reports suggest iPhones account for a third of all smartphones in use. We report on the first large-scale analysis of app usage patterns on iPhones. We conduct a reproduction study with a cohort of over 10,000 jailbroken iPhone users, reproducing several studies previously conducted on Android devices. We find some differences, but also significant similarities: e.g. communications apps are the most used on both platforms; similar patterns are apparent of few apps being very popular but there existing a 'long tail' of many apps used by the population; users show similar patterns of 'micro-usage'; almost identical proportions of people use a unique combination of apps. Such similarities add confidence but also specificity about claims of consistency across smartphones. As well as presenting our findings, we discuss issues involved in reproducing studies across platforms.
Underestimates of intussusception rates among US infants based on inpatient discharge data: implications for monitoring the safety of rotavirus vaccines.

BACKGROUND Because a previous rotavirus vaccine was associated with intussusception, new rotavirus vaccines are monitored postlicensure for any such association. Accurate background intussusception rates are needed to determine whether the number of cases observed after vaccination exceeds that expected by chance. Previously, intussusception rates were obtained from inpatient discharge databases. We sought to determine the rate of intussusception among infants managed only with short-stay or emergency department care. METHODS Intussusception cases occurring in infants were identified retrospectively at 3 children's hospitals from January 2001 through March 2006, a period without rotavirus vaccine use, by a search of discharge, billing, and radiology databases for International Classification of Diseases, Ninth Revision, Clinical Modification code 560.0 (intussusception) and procedure codes and by review of medical records. RESULTS Of 156 infants with intussusception fulfilling Brighton level 1 criteria, 81 (52%) were billed as inpatients, 68 (44%) as short-stay patients, and 7 (4%) as emergency department patients only. The use of only inpatients assigned code 560.0 underestimated the total number of level 1 cases at the hospitals by 44%. The mean annual intussusception rate for the hospitals' catchment counties was 49.3 cases per 100,000 live births (inpatient cases: 27.1 cases per 100,000 live births; short-stay or emergency department cases: 22.3 cases per 100,000 live births). CONCLUSIONS Intussusception rates based solely on inpatient discharge databases could underestimate the true incidence of level 1 intussusception by >40%. Background rates used for assessment of risk after vaccination should account for cases managed only with short-stay or emergency department care.
Wall++: Room-Scale Interactive and Context-Aware Sensing

Human environments are typified by walls, homes, offices, schools, museums, hospitals and pretty much every indoor context one can imagine has walls. In many cases, they make up a majority of readily accessible indoor surface area, and yet they are static their primary function is to be a wall, separating spaces and hiding infrastructure. We present Wall++, a low-cost sensing approach that allows walls to become a smart infrastructure. Instead of merely separating spaces, walls can now enhance rooms with sensing and interactivity. Our wall treatment and sensing hardware can track users' touch and gestures, as well as estimate body pose if they are close. By capturing airborne electromagnetic noise, we can also detect what appliances are active and where they are located. Through a series of evaluations, we demonstrate Wall++ can enable robust room-scale interactive and context-aware applications.
Gene Therapy Using Adeno-Associated Virus Vectors

SUMMARY The unique life cycle of adeno-associated virus (AAV) and its ability to infect both nondividing and dividing cells with persistent expression have made it an attractive vector. An additional attractive feature of the wild-type virus is the lack of apparent pathogenicity. Gene transfer studies using AAV have shown significant progress at the level of animal models; clinical trials have been noteworthy with respect to the safety of AAV vectors. No proven efficacy has been observed, although in some instances, there have been promising observations. In this review, topics in AAV biology are supplemented with a section on AAV clinical trials with emphasis on the need for a deeper understanding of AAV biology and the development of efficient AAV vectors. In addition, several novel approaches and recent findings that promise to expand AAV's utility are discussed, especially in the context of combining gene therapy ex vivo with new advances in stem or progenitor cell biology.
PCA vs. ICA: A Comparison on the FERET Data Set

Over the last ten years, face recognition has become a specialized applications area within the field of computer vision. Sophisticated commercial systems have been developed that achieve high recognition rates. Although elaborate, many of these systems include a subspace projection step and a nearest neighbor classifier. The goal of this paper is to rigorously compare two subspace projection techniques within the context of a baseline system on the face recognition task. The first technique is principal component analysis (PCA), a well-known “baseline” for projection techniques. The second technique is independent component analysis (ICA), a newer method that produces spatially localized and statistically independent basis vectors. Testing on the FERET data set (and using standard partitions), we find that, when a proper distance metric is used, PCA significantly outperforms ICA on a human face recognition task. This is contrary to previously published results.
Spatially-Explicit Estimation of Geographical Representation in Large-Scale Species Distribution Datasets

Much ecological research relies on existing multispecies distribution datasets. Such datasets, however, can vary considerably in quality, extent, resolution or taxonomic coverage. We provide a framework for a spatially-explicit evaluation of geographical representation within large-scale species distribution datasets, using the comparison of an occurrence atlas with a range atlas dataset as a working example. Specifically, we compared occurrence maps for 3773 taxa from the widely-used Atlas Florae Europaeae (AFE) with digitised range maps for 2049 taxa of the lesser-known Atlas of North European Vascular Plants. We calculated the level of agreement at a 50-km spatial resolution using average latitudinal and longitudinal species range, and area of occupancy. Agreement in species distribution was calculated and mapped using Jaccard similarity index and a reduced major axis (RMA) regression analysis of species richness between the entire atlases (5221 taxa in total) and between co-occurring species (601 taxa). We found no difference in distribution ranges or in the area of occupancy frequency distribution, indicating that atlases were sufficiently overlapping for a valid comparison. The similarity index map showed high levels of agreement for central, western, and northern Europe. The RMA regression confirmed that geographical representation of AFE was low in areas with a sparse data recording history (e.g., Russia, Belarus and the Ukraine). For co-occurring species in south-eastern Europe, however, the Atlas of North European Vascular Plants showed remarkably higher richness estimations. Geographical representation of atlas data can be much more heterogeneous than often assumed. Level of agreement between datasets can be used to evaluate geographical representation within datasets. Merging atlases into a single dataset is worthwhile in spite of methodological differences, and helps to fill gaps in our knowledge of species distribution ranges. Species distribution dataset mergers, such as the one exemplified here, can serve as a baseline towards comprehensive species distribution datasets.
BreathVR: Leveraging Breathing as a Directly Controlled Interface for Virtual Reality Games

With virtual reality head-mounted displays rapidly becoming accessible to mass audiences, there is growing interest in new forms of natural input techniques to enhance immersion and engagement for players. Research has explored physiological input for enhancing immersion in single player games through indirectly controlled signals like heart rate or galvanic skin response. In this paper, we propose breathing as a directly controlled physiological signal that can facilitate unique and engaging play experiences through natural interaction in single and multiplayer virtual reality games. Our study (N = 16) shows that participants report a higher sense of presence and find the gameplay more fun and challenging when using our breathing actions. From study observations and analysis we present five design strategies that can aid virtual reality game designers interested in using directly controlled forms of physiological input.
Disaccharidase Activities in Small Intestine of Rotavirus‐Infected Suckling Mice: A Histochemical Study

A histochemical study of the time course of the appearance and location of lactase and α-glucosidase (used to detect sucrase and maltase) activities was carried out on control and rotavirus-infected mice from 7 to 14 days old. The overall pattern of enzyme activity was in agreement with previous quantitative studies on the activities of these enzymes. No evidence was obtained to support the idea that lactase deficiency was the result of repopulation of villi (denuded of lactase-producing villus cells) with immature lactase-negative cells. Low lactase activity was more likely to reflect profound changes in metabolically crippled cells, and recovery of lactase activity with recovery of normal metabolic functions. The location of enzyme activity to brush border regions rather than the cytoplasm of villus enterocytes enhances the significance of previous quantitative studies on these enzymes. The timing and duration of diminished lactase activities were such that they were unlikely to cause the induction or perpetuation of diarrhea in murine rotavirus diarrhea. The appearance in infected animals of α-glucosidase 3 days earlier than normal indicates that, in addition to reversible changes seen with lactase, developmental changes were accelerated that affected both crypt and villus cells.
Chest wall tuberculosis - A clinical and imaging experience

Abstract Aims: Tuberculous infection of the thoracic cage is rare and is difficult to discern clinically or on radiographs. This study aims to describe the common sites and the imaging appearances of chest wall tuberculosis. Materials and Methods: A retrospective review of the clinical and imaging records of 12 confirmed cases of thoracic cage tuberculosis (excluding that of the spine), seen over the last 7 years, was performed. Imaging studies available included radiographs, ultrasonographies (USGs), and computed tomography (CT) scans. Pathological confirmation was obtained in all cases. Results: All patients had clinical signs and symptoms localized to the site of involvement, whether it was the sternum, sternoclavicular joints, or ribs. CT scan revealed sternal destruction in three patients and osteolytic lesions with sclerosis of the articular surfaces of the sternoclavicular joints in two patients. In five patients with rib lesions, USG elegantly demonstrated the bone destruction underlying the cold abscess. All cases were confirmed to be of tuberculous origin by pathology studies of the aspirated/curetted material, obtained by CT / USG guidance. Conclusions: Tuberculous etiology should be considered for patients presenting with atypical sites of skeletal inflammation. CT scan plays an important role in the evaluation of these patients. However, the use of USG for demonstrating rib destruction in a chest wall cold abscess has so far been under-emphasized, as has been the role of CT and USG guided aspiration in confirming the aetiology.
Vitamin D and multiple sclerosis: Potential pathophysiological role and clinical implications

Multiple sclerosis (MS) is thought to arise due to an interplay of genetic and environmental risk factors. Vitamin D, besides maintaining bone health and calcium metabolism, is thought to play an immunomodulatory role in the central nervous system. Studies have shown that patients with the highest level of Vitamin D (99–152 nmol/l) had a significantly lower risk of MS than the subgroup with the lowest levels (15–63 nmol/l). Furthermore, populations having a high oral intake of vitamin D had a decreased risk of MS. Hypovitaminosis D is one of the environmental risk factors for MS based on numerous physiological, experimental and epidemiologic data, which can be corrected to provide an effective therapeutic option for this debilitating disease.
Numerical Simulation and Cold Test of a Compact 2G HTS Power Cable

Superconductinge power cables offer the advantages of lower loss, lighter weight, and smaller dimensions, in comparison with conventional cables. It is important to developed most compact cable with a small diameter to increase the transmission power density of a cable. Precise analysis should be used to provide optimal cable layout with uniform current distribution among layers. We have developed an electric circuit model of a cable, and two FEM models using a finite-element code ANSYS. The numerical simulations can provide detailed information about the current distribution inside the cable and the optimal parameters from the point of view of current distribution of the cable have been determined. On the base of the models, the compact 2G HTS cable model with three layers in the core and two layers in the shield has been produced and tested. The outer diameter of the cable was as small as ∼20 mm that is less than previously 1G and 2G HTS power cables tested. The experiment with the model cable demonstrated that even rather small mistake in the diameter of a layer leads to considerable change of current distribution among layers. This phenomenon was analyzed with the simulation models developed. It was shown that change of a layer diameter as small as the thickness of one tape (∼0.1 mm) led to the current distribution change observed. Calculated results qualitatively coincide with the experiments. In addition, ac losses at different frequencies have been measured to compare them with ac loss in previously tested cables with larger diameter.
A Survey about the Usage of Semantic Technologies for the Description of Robotic Components and Capabilities

to the axiomatic description of components and their features in order to foster the utilization and interoperability between components and applications using ontological domain and task semantics. This work therefore surveys the current state of the art in using semantic technologies and ontology-based knowledge representation frameworks for the description of robotic components and their capabilities. A special emphasis is given to the practical application of such technologies in current robotic projects as well as on initiatives that aim at building industry-wide vocabularies.
Multidisciplinary Ophthalmic Imaging In Vivo Imaging of a New Indocyanine Green Micelle Formulation in an Animal Model of Laser-Induced Choroidal Neovascularization

Citation: Meyer J, Cunea A, SonntagBensch D, et al. In vivo imaging of a new indocyanine green micelle formulation in an animal model of laserinduced choroidal neovascularization. Invest Ophthalmol Vis Sci. 2014;55:6204–6212. DOI:10.1167/ iovs.13-13617 PURPOSE. We investigated a novel formulation of indocyanine green (ICG/HS 15) in an animal model of laser-induced choroidal neovascularization (CNV).
Influenza A viruses: an ecology review

In humans, influenza A viruses cause yearly outbreaks with high morbidity and excess fatality rates as a direct effect. Placed in its ecological niche, however – in dabbling ducks – avian influenza virus (AIV) induces quite a mild disease. It is when the virus crosses the species barrier that pathogenic traits are attributed to infection. When infecting phylogenetically more distant species (i.e. chicken and turkeys), the AIV can cause high morbidity and may in some cases change the virus into a highly pathogenic variant with nearly 100% fatality rate. Being a very adaptable virus, these spill-over events are frequent and numerous species are susceptible to influenza virus. When a subtype of AIV that has not previously infected humans crosses the species barrier, adapts to humans, and spreads easily, a pandemic event is imminent. There is no cure for influenza infection and vaccination is a cumbersome endeavor so, currently, the strategy when a pandemic strikes is damage control. The interest in AIV ecology has increased dramatically since the beginning of the millennium as a key factor for preventive work for future pandemics. This review gives a broad overview of influenza A virus ecology: in the natural host, accidental hosts, new endemic hosts, and humans.