Miracle-dz/UniFAR-FTUs huggingface dataset:
Upaya Mengatasi Kecanduan Anak Terhadap Gawai (Gadget) Melalui Model Komunikasi Interaktif Orang Tua dan Anak Berdasar Al-Quran

In the modern era, the use of devices is already very widespread, even among children. Devices enable children from accessing information easily and quickly. Otherwise, devices also offer other things, such as games and entertainment that can lead to addiction. Meanwhile, the communication between parents and children often have problems that affect loosening the relationship between them. The purposes of this article are to determine the negative impact of device addiction to the children, how are the forms of interactive communication between parents and children exemplified by the Quran, and how can the interactive communication be an effort to save children from device addiction. The negative impacts of device addiction are such as decreased concentration, lack of emotional control, and health disorder. Interactive communication between parents and children in the Quran such as the story of Prophet Abraham who discussed and listened to the opinion of Ismael, Prophet Zakariya who used to be critical and inquisitive about unusual phenomena experienced by Maryam, Lukman Al Hakim showed a good way in advising the child, and Nuh gave an example of how to reprimand Kan'an. With those kinds of interactive communication models, hopefully parents can find the right way to communicate and could successfully counseled the children to release them from device addiction.Keywords: Gadget, mobile phone, interactive communication model
Credit transmission mechanism in Turkey: An empirical investigation

The purpose of the study is to empirically test the presence of a bank lending channel in the Turkish economy. The empirical investigations are focused on the bank lending behaviour of 58 deposit money banks in the Turkish banking system over the period 1988-1999. The estimation methodology of the empirical analysis differs from that of similar studies in the literature, providing econometrically more efficient model estimates through exploiting dynamic panel data modelling with Generalized Method of Moments estimations. The results of the model estimations provide no evidence of a potential for a bank lending channel to exist in the Turkish economy. Such an outcome is reflected in the lack of a significant relationship between the change in the monetary policy indicator and the growth rate of the loan supply in the estimated models. Categorizing the loan supply responses of banks with respect to bank size differences has not provided any significant improvement in revealing the evidence of a bank lending channel. The empirical results indicate that bank lending behaviour is influenced significantly by bank specific factors, such as the balance sheet strength and the quality of the asset portfolio, and by debt sales to the banking system.
Bulk Heterojunction Morphologies with Atomistic Resolution from Coarse-Grain Solvent Evaporation Simulations

Control over the morphology of the active layer of bulk heterojunction (BHJ) organic solar cells is paramount to achieve high-efficiency devices. However, no method currently available can predict morphologies for a novel donor–acceptor blend. An approach which allows reaching relevant length scales, retaining chemical specificity, and mimicking experimental fabrication conditions, and which is suited for high-throughput schemes has been proven challenging to find. Here, we propose a method to generate atom-resolved morphologies of BHJs which conforms to these requirements. Coarse-grain (CG) molecular dynamics simulations are employed to simulate the large-scale morphological organization during solution-processing. The use of CG models which retain chemical specificity translates into a direct path to the rational design of donor and acceptor compounds which differ only slightly in chemical nature. Finally, the direct retrieval of fully atomistic detail is possible through backmapping, opening the way for improved quantum mechanical calculations addressing the charge separation mechanism. The method is illustrated for the poly(3-hexyl-thiophene) (P3HT)–phenyl-C61-butyric acid methyl ester (PCBM) mixture, and found to predict morphologies in agreement with experimental data. The effect of drying rate, P3HT molecular weight, and thermal annealing are investigated extensively, resulting in trends mimicking experimental findings. The proposed methodology can help reduce the parameter space which has to be explored before obtaining optimal morphologies not only for BHJ solar cells but also for any other solution-processed soft matter device.
The Mere Co-Presence: Synchronization of Autonomic Signals and Emotional Responses across Co-Present Individuals Not Engaged in Direct Interaction

Existing evidence suggests that in social contexts individuals become coupled in their emotions and behaviors. Furthermore, recent biological studies demonstrate that the physiological signals of interacting individuals become coupled as well, exhibiting temporally synchronized response patterns. However, it is yet unknown whether people can shape each other's responses without the direct, face-to-face interaction. Here we investigated whether the convergence of physiological and emotional states can occur among “merely co-present” individuals, without direct interactional exchanges. To this end, we measured continuous autonomic signals and collected emotional responses of participants who watched emotional movies together, seated side-by-side. We found that the autonomic signals of co-present participants were idiosyncratically synchronized and that the degree of this synchronization was correlated with the convergence of their emotional responses. These findings suggest that moment-to-moment emotional transmissions, resulting in shared emotional experiences, can occur in the absence of direct communication and are mediated by autonomic synchronization.
Brief take-home laughter yoga practice (B-TLYP): impact on multi-dimensional affects among Chinese adults in Hong Kong

ABSTRACT Objective: To examine the impact of a brief take-home laughter yoga practice (B-TLYP) on the multi-dimensional affects among Chinese adults in Hong Kong. Method: The intervention consisted of a one-hour workshop and 7-day home practice on laughter yoga exercises. Thirty-six adults (mean age: 48.3 years) joined the intervention and completed questionnaires on demographics and affect scales. Positive affect (PA) and negative affect (NA) were measured by the Positive and Negative Affect Scale (PANAS) at baseline, immediately and one week after the intervention. Repeated measure ANOVA was used to examine differences in PANAS scores across time. Results: The mean score of PANAS PA subscale showed an increasing trend across time, whereas there was no difference in the mean score of PANAS NA subscale. Discussion: This study provides preliminary support for the benefits of B-TLYP on adults’ positive affect.
HIV-1 Induces DCIR Expression in CD4+ T Cells

The C-type lectin receptor DCIR, which has been shown very recently to act as an attachment factor for HIV-1 in dendritic cells, is expressed predominantly on antigen-presenting cells. However, this concept was recently challenged by the discovery that DCIR can also be detected in CD4+ T cells found in the synovial tissue from rheumatoid arthritis (RA) patients. Given that RA and HIV-1 infections share common features such as a chronic inflammatory condition and polyclonal immune hyperactivation status, we hypothesized that HIV-1 could promote DCIR expression in CD4+ T cells. We report here that HIV-1 drives DCIR expression in human primary CD4+ T cells isolated from patients (from both aviremic/treated and viremic/treatment naive persons) and cells acutely infected in vitro (seen in both virus-infected and uninfected cells). Soluble factors produced by virus-infected cells are responsible for the noticed DCIR up-regulation on uninfected cells. Infection studies with Vpr- or Nef-deleted viruses revealed that these two viral genes are not contributing to the mechanism of DCIR induction that is seen following acute infection of CD4+ T cells with HIV-1. Moreover, we report that DCIR is linked to caspase-dependent (induced by a mitochondria-mediated generation of free radicals) and -independent intrinsic apoptotic pathways (involving the death effector AIF). Finally, we demonstrate that the higher surface expression of DCIR in CD4+ T cells is accompanied by an enhancement of virus attachment/entry, replication and transfer. This study shows for the first time that HIV-1 induces DCIR membrane expression in CD4+ T cells, a process that might promote virus dissemination throughout the infected organism.
Kinematics of nearby subdwarf stars

We present an analysis of the space motions of 742 subdwarf stars based on the sample of Carney et al. (1994, AJ, 107, 22 40). Hipparcos parallaxes, TYC2+HIP proper motions and Tycho 2 proper motions were combined with radial velocities and metallicities from CLLA. The kinematical behavior is discussed in particular in relation to their metallicities. The majority of these sample stars have metal abundances of [Fe/H] $>-1$ and represent the thick disk population. The halo component, with [Fe/H] $<-1.6$, is characterized by a low mean rotation velocity and a radially elongated velocity ellipsoid. In the intermediate metallicity range ($-1.6\leq$ [Fe/H] $\leq-1$), we find a significant number of subdwarfs with disklike kinematics. We interpret this population of stars as a metal-weak thick disk (MWTD) population.
Relationship Between Internal Audit Practices And Performance Of Water Service Providers In Kenya

The purpose of this study was to establish the relationship between internal audit and organisational performance of Kenyan WSPs. To fulfil the study objective, hypothesis was derived and tested on a population of 93 Water service providers. This cross sectional descriptive study was guided by a positivist study paradigm. The Data Envelopment Analysis approach was used to codify the dependent variable and regression analysis was then applied to test the hypothesis. The null hypothesis was rejected as the regression analysis found that 10.1% of variations in firm performance are explained by variation in internal audit while 89.9% of variations are explained by other variables. This infers that internal audit influences performance of Water service providers in Kenya. The study made contribution to policy formulation and development to benefit the understanding on how internal audit in the Kenyan context influence organizational performance resulting to formulation of reforms in various public institutions to strengthen internal audit.
Stigma, Stress, and Stories: Refining our Understanding of Suicidal Behavior among Adult Gay, Bisexual, and other Sexual Minority Men

Background: Sexual minority men are approximately four times more likely than heterosexual men to have attempted suicide. Epidemiologic evidence of this disparity is robust; however, research exploring how and why this disparity persists is sparse. Objective: To refine our understanding of suicidal behavior in adult sexual minority men, with the goal of improving relevant public health strategies to prevent suicide. Methods and aims: Data were drawn from adult sexual minority men who participated in: the population-based Canadian Community Health Survey (N=4675), a gay men’s community-based national online survey (N=7872), and in-depth interviews with men who attempted suicide (N=7). Quantitative bias analysis was used to estimate the degree of misclassification of sexual orientation and associated bias in estimates of suicidal ideation among sexual minority men in general population-based surveys (Aim 1). Structural equation modeling was used to identify specific psychosocial challenges that mediate relationships between constructs of sexual stigma and recent suicide attempts (Aim 2). Dialogical narrative analysis was used to construct life narratives used by sexual minority men with histories of suicide attempts (Aim 3).
The Effects of a Physical Education Program on the Motor Skill Performance of Children with Autism Spectrum Disorder

The purpose of this study was to evaluate the effects of a 40-minute physical education class provided twice a week for six months on the performance of motor skills in 37 children with autism spectrum disorder (ASD) aged 5 to 12 years. A repeated-measures design and the Test of Gross Motor Development (TGMD-2) (Ulrich, 2000) were used to examine six-month changes in six locomotor and six object control skills. The locomotor skills included the run, slide, gallop, hop, leap, and horizontal jump. The object control skills included the underhand roll, catch, overhand throw, stationary bounce, kick, and ball strike. Paired t -tests were used to determine whether there were physical education-related changes in motor skills. The 37 children with ASD demonstrated improvements in 10 of the 12 motor skills ( p ≤ 0.020) after six months of the twice weekly physical education class.
Simulating psoriasis by altering transit amplifying cells

Computational models of tissue homeostasis will facilitate a deeper understanding of many diseases. They link molecular networks, cellular differentiation and the spatial and temporal organization of tissues. Here we show an approach which is able to computationally turn a healthy in silico epidermis into one with four central properties of psoriatic epidermis. We achieve this by altering a single simulation parameter in the cellular differentiation program of the simulated epidermal keratinocytes: the fractional time period during which transit amplifying cells proliferate (tau). Prolonging tau results in the four main pathological characteristics of psoriatic skin: (1) an absolute increase of the germinative compartment, (2) an absolute increase of the differentiated compartment, (3) a higher proportion of germinative cells and (4) a marked reduction in turnover time. The prolongation of tau is able to increase the proliferation capacity of the epidermal tissue without altering the cell cycle frequency.
Choice and Design of Adjuvants for Parenteral and Mucosal Vaccines

The existence of pathogens that escape recognition by specific vaccines, the need to improve existing vaccines and the increased availability of therapeutic (non-infectious disease) vaccines necessitate the rational development of novel vaccine concepts based on the induction of protective cell-mediated immune responses. For naive T-cell activation, several signals resulting from innate and adaptive interactions need to be integrated, and adjuvants may interfere with some or all of these signals. Adjuvants, for example, are used to promote the immunogenicity of antigens in vaccines, by inducing a pro-inflammatory environment that enables the recruitment and promotion of the infiltration of phagocytic cells, particularly antigen-presenting cells (APC), to the injection site. Adjuvants can enhance antigen presentation, induce cytokine expression, activate APC and modulate more downstream adaptive immune reactions (vaccine delivery systems, facilitating immune Signal 1). In addition, adjuvants can act as immunopotentiators (facilitating Signals 2 and 3) exhibiting immune stimulatory effects during antigen presentation by inducing the expression of co-stimulatory molecules on APC. Together, these signals determine the strength of activation of specific T-cells, thereby also influencing the quality of the downstream T helper cytokine profiles and the differentiation of antigen-specific T helper populations (Signal 3). New adjuvants should also target specific (innate) immune cells in order to facilitate proper activation of downstream adaptive immune responses and homing (Signal 4). It is desirable that these adjuvants should be able to exert such responses in the context of mucosal administered vaccines. This review focuses on the understanding of the potential working mechanisms of the most well-known classes of adjuvants to be used effectively in vaccines.
Hybrid One-Shot 3D Hand Pose Estimation by Exploiting Uncertainties

Model-based approaches to 3D hand tracking have been shown to perform well in a wide range of scenarios. However, they require initialisation and cannot recover easily from tracking failures that occur due to fast hand motions. Data-driven approaches, on the other hand, can quickly deliver a solution, but the results often suffer from lower accuracy or missing anatomical validity compared to those obtained from model-based approaches. In this work we propose a hybrid approach for hand pose estimation from a single depth image. First, a learned regressor is employed to deliver multiple initial hypotheses for the 3D position of each hand joint. Subsequently, the kinematic parameters of a 3D hand model are found by deliberately exploiting the inherent uncertainty of the inferred joint proposals. This way, the method provides anatomically valid and accurate solutions without requiring manual initialisation or suffering from track losses. Quantitative results on several standard datasets demonstrate that the proposed method outperforms state-of-the-art representatives of the model-based, data-driven and hybrid paradigms.
Kinematic Structure of the Orion Nebula Cluster and Its Surroundings

We present results from 1351 high-resolution spectra of 1215 stars in the Orion Nebula Cluster (ONC) and the surrounding Orion 1c association, obtained with the Hectochelle multiobject echelle spectrograph on the 6.5 m MMT. We confirmed 1111 stars as members, based on their radial velocity and/or Hα emission. The radial velocity distribution of members shows a dispersion of σ = 3.1 km s−1. We found a substantial north-south velocity gradient and spatially coherent structure in the radial velocity distribution, similar to that seen in the molecular gas in the region. We also identified several binary and high velocity stars, a region exhibiting signs of triggered star formation, and a possible foreground population of stars somewhat older than the ONC. Stars without infrared excesses (as detected with the IRAC instrument on the Spitzer Space Telescope) exhibit a wider spread in radial velocity than the infrared excess stars; this spread is mostly due to a blueshifted population of stars that may constitute a foreground population. We also identify some accreting stars, based on Hα, that do not have detectable infrared excesses with IRAC, and thus are potential transitional disk systems (objects with inner disk holes). We propose that the substructure seen in both the stellar and gaseous components is the result of nonuniform gravitational collapse to a filamentary distribution of gas. The spatial and kinematic correlation between the stellar and gaseous components suggests that the region is very young, probably only ~1 crossing time old or less, to avoid shock dissipation and gravitational interactions which would tend to destroy the correlation between stars and gas.
Complete Genome and Transcriptomes of Streptococcus parasanguinis FW213: Phylogenic Relations and Potential Virulence Mechanisms

Streptococcus parasanguinis, a primary colonizer of the tooth surface, is also an opportunistic pathogen for subacute endocarditis. The complete genome of strain FW213 was determined using the traditional shotgun sequencing approach and further refined by the transcriptomes of cells in early exponential and early stationary growth phases in this study. The transcriptomes also discovered 10 transcripts encoding known hypothetical proteins, one pseudogene, five transcripts matched to the Rfam and additional 87 putative small RNAs within the intergenic regions defined by the GLIMMER analysis. The genome contains five acquired genomic islands (GIs) encoding proteins which potentially contribute to the overall pathogenic capacity and fitness of this microbe. The differential expression of the GIs and various open reading frames outside the GIs at the two growth phases suggested that FW213 possess a range of mechanisms to avoid host immune clearance, to colonize host tissues, to survive within oral biofilms and to overcome various environmental insults. Furthermore, the comparative genome analysis of five S. parasanguinis strains indicates that albeit S. parasanguinis strains are highly conserved, variations in the genome content exist. These variations may reflect differences in pathogenic potential between the strains.
Cooperative caching and relaying strategies for peer-to-peer content delivery

Peer-to-peer content distribution has become a major source of bandwidth costs for Internet service providers (ISPs). One way for ISPs to decrease these costs is to deploy caches for p2p traffic. To make efficient use of the caches, in this paper we propose a cooperative caching and relaying scheme that is compatible with the existing business relations between ISPs. We formulate the problem of cooperative caches as a resource allocation problem, and show that it is related to the problem of r-configuration studied in graph theory. We propose a distributed algorithm to solve the resource allocation problem, and show that cooperation leads to significant gains compared to non-cooperative caching.
DIET AND INFLAMMATION: FOCUS ON THE SMALL INTESTINE AND ADIPOSE TISSUE

of their signature gene, CD3, compared with SD-fed mice. Interestingly, our results demonstrate a significant relative increase of Treg and Th17 with respect the total T cell population in WD-fed TLR2 and TLR4 KO mice. The Treg/Th17 ratio shows a relative reduction of the Treg subset, which was significant only in WD-fed TLR2 KO mice. Recent evidence demonstrates that composition of the microbiota regulates the Th17:Treg balance (49). Moreover, Sutmuller et al demonstrate that TLR2, but not TLR4, controls the expansion and function of regulatory T cells, establishing a direct link between TLR and the modulation of immune response through Treg Our data add support for a possible role for TLR2 and TLR4 signaling in the balance of anti-inflammatory versus inflammatory response in the gut. In the absence of absolute T cell quantification and functional experiments (suppression assays), it would be difficult to further define the exact nature of the effect of these two receptors.
Metabolic and Phenotypic Differences between Mice Producing a Werner Syndrome Helicase Mutant Protein and Wrn Null Mice

Werner syndrome (WS) is a premature aging disorder caused by mutations in a RecQ-family DNA helicase, WRN. Mice lacking part of the helicase domain of the WRN orthologue exhibit many phenotypic features of WS, including metabolic abnormalities and a shorter mean life span. In contrast, mice lacking the entire Wrn protein (i.e. Wrn null mice) do not exhibit a premature aging phenotype. In this study, we used a targeted mass spectrometry-based metabolomic approach to identify serum metabolites that are differentially altered in young Wrn helicase mutant and Wrn null mice. An antibody-based quantification of 43 serum cytokines and markers of cardiovascular disease risk complemented this study. We found that Wrn helicase mutants exhibited elevated and decreased levels, respectively, of the anti-inflammatory cytokine IL-10 and the pro-inflammatory cytokine IL-18. Wrn helicase mutants also exhibited an increase in serum hydroxyproline and plasminogen activator inhibitor-1, markers of extracellular matrix remodeling of the vascular system and inflammation in aging. We also observed an abnormal increase in the ratio of very long chain to short chain lysophosphatidylcholines in the Wrn helicase mutants underlying a peroxisome perturbation in these mice. Remarkably, the Wrn mutant helicase protein was mislocalized to the endoplasmic reticulum and the peroxisomal fractions in liver tissues. Additional analyses with mouse embryonic fibroblasts indicated a severe defect of the autophagy flux in cells derived from Wrn helicase mutants compared to wild type and Wrn null animals. These results indicate that the deleterious effects of the helicase-deficient Wrn protein are mediated by the dysfunction of several cellular organelles.