Miracle-dz/UniFAR-FTUs huggingface dataset:
Comparative analysis of flip-flop architectures for subthreshold applications in 28nm FDSOI

Nine D flip-flop architectures were implemented in 28nm FDSOI at a target, subthreshold, supply voltage of 200mV. The goal was to identify promising D flip-flops for ultra low power applications. The pass gate flip-flop was implemented using 49% of the S2CFF's area and was functional at the lowest operating voltage of 65mV in the typical process corner. At the targeted supply voltage of 200mV the racefree DFF gives the best functional yield of 99.8%. The flip-flops having the shortest D-Q delays were the PowerPC 603 and the transmission gate D flip-flop. These also had the lowest power delay products of 52.08aJ and 61.09aJ respectively.
Body Size as a Driver of Scavenging in Theropod Dinosaurs

Theropod dinosaurs dominated Earth’s terrestrial ecosystem as a diverse group of predators for more than 160 million years, yet little is known about their foraging ecology. Maintaining a balanced energy budget presented a major challenge for therapods, which ranged from the chicken‐sized Microraptor up to the whale‐sized Giganotosaurus, in the face of intense competition and the demands of ontogenetic growth. Facultative scavenging, a behavior present in almost all modern predators, may have been important in supplementing energetically expensive lifestyles. By using agent‐based models based on the allometric relationship between size and foraging behaviors, we show that theropods between 27 and 1,044 kg would have gained a significant energetic advantage over individuals at both the small and large extremes of theropod body mass through their scavenging efficiency. These results were robust to rate of competition, primary productivity, and detection distance. Our models demonstrate the potential importance of facultative scavenging in theropods and the role of body size in defining its prevalence in Mesozoic terrestrial systems.
Management Outcomes of Colonoscopic Perforations Are Affected by the General Condition of the Patients

Purpose The management of a colonoscopic perforation (CP) varies from conservative to surgical. The objective of this study was to evaluate the outcomes between surgical and conservative treatment of patients with a CP. Methods From 2003 to 2016, the medical records of patients with CP were retrospectively reviewed. Patients were divided into 2 groups depending on whether they initially received conservative or surgical treatment. Results During the study period, a total of 48 patients with a CP were treated. Among them, 5 patients had underlying colorectal cancer and underwent emergency radical cancer surgery; these patients were excluded. The mean age of the remaining 43 patients was 64.5 years old, and the most common perforation site was the sigmoid colon (15 patients). The initial conservative care group included 16 patients, and the surgery group included 27 patients. In the conservative group, 5 patients required conversion to surgery (failure rate: 5 of 16 [31.3%]). Of the surgery group, laparoscopic surgery was performed on 19 patients and open surgery on 8 patients, including 2 conversion cases. Major postoperative complications developed in 11 patients (34.4%), and postoperative mortality developed in 4 patients (12.5%). The only predictor for poor prognosis after surgery was a high American Society of Anesthesiologists physical status classification. Conclusion In this study, conservative treatment for patients with a CP had a relatively high failure rate. Furthermore, surgical treatment showed significant rates of complications and mortality, which depended on the general status of the patients.
Pre-main sequence spectroscopic binaries suitable for VLTI observations ,

Context. A severe problem for research in star-formation is that the masses of young stars are almost always estimated from evolutionary tracks alone. Since the tracks published by different groups differ, it is often only possible to give a rough estimate of the masses of young stars. It is thus crucial to test and calibrate the tracks. Up to now, only a few tests of the tracks could be carried out. However, it is now possible with the VLTI to set constrains on the tracks by determining the masses of many young binary stars precisely. Aims. In order to use the VLTI efficiently, a first step is to find suitable targets, which is the purpose of this work. Given the distance of nearby star-forming regions, suitable VLTI targets are binaries with orbital periods between at least 50 days and a few years. Although a number of surveys for detecting spectroscopic binaries have been carried out, most of the binaries found so far have periods that are too short. Methods. We thus surveyed the Chamaeleon, Corona Australis, Lupus, Sco-Cen, and ρ Ophiuci star-forming regions in order to search for spectroscopic binaries with periods longer than 50 days, which are suitable for the VLTI observations. Results. As a result of the 8 year campaign, we discovered 8 binaries with orbital periods longer than 50 days. Amongst the newly discovered long-period binaries is CS Cha, which is one of the few classical T Tauri stars with a circumbinary disk. The survey is
Task Specific Visual Saliency Prediction with Memory Augmented Conditional Generative Adversarial Networks

Visual saliency patterns are the result of a variety of factors aside from the image being parsed, however existing approaches have ignored these. To address this limitation, we propose a novel saliency estimation model which leverages the semantic modelling power of conditional generative adversarial networks together with memory architectures which capture the subject's behavioural patterns and task dependent factors. We make contributions aiming to bridge the gap between bottom-up feature learning capabilities in modern deep learning architectures and traditional top-down handcrafted features based methods for task specific saliency modelling. The conditional nature of the proposed framework enables us to learn contextual semantics and relationships among di.erent tasks together, instead of learning them separately for each task. Our studies not only shed light on a novel application area for generative adversarial networks, but also emphasise the importance of task specific saliency modelling and demonstrate the plausibility of fully capturing this context via an augmented memory architecture.
Efficacy and Tolerability of Telaprevir for Chronic Hepatitis Virus C Genotype 1 Infection: A Meta-Analysis

Background Chronic hepatitis C virus (HCV) infection is one of the leading causes of hepatic cirrhosis and hepatocellular carcinoma, and HCV genotype 1 is the most prevalent genotype and is resistant to current standard therapy. We performed this meta-analysis to evaluate the efficacy and safety of telaprevir-based therapy for chronic HCV genotype 1 infection. Methods We included randomized controlled trials with no year or language restriction. All data were analyzed using a random-effects model by Review Manager v5.0. The primary outcome was the proportion of patients achieving sustained virologic response (SVR), and the secondary outcomes were HCV relapse rate, incidence of severe adverse events (SAEs), and discontinuation due to adverse events. Results The proportion of achieving SVR was significantly higher in the telaprevir group (odds ratio [OR] = 3.40 [1.92, 6.00], P<0.0001; I2 = 87%) regardless of a patients’ previous treatment status. It was also significantly higher in the 24-week and 48-week treatment groups (OR = 4.52 [2.08, 9.81], P<0.001; I2 = 85%, and OR = 4.05 [1.56, 10.56], P = 0.004; I2 = 92%, respectively), while it was comparable in the 12-week treatment group (OR = 1.32 [0.63, 2.75], P = 0.46; I2 = 35%). In addition, the HCV relapse rate was significantly reduced in the telaprevir group (OR = 0.28 [0.16, 0.49], P<0.001; I2 = 76%). However, the incidence of SAE (OR = 1.56 [1.15, 2.10], P = 0.004; I2 = 0%) and study discontinuation due to adverse events (OR = 2.24 [1.43, 3.50], P<0.001; I2 = 37%) were significantly higher in the telaprevir group. Conclusion Despite its higher incidence of SAEs and discontinuation due to adverse events, telaprevir-based therapy can increase the proportion of achieving SVR in both previously treated and untreated chronic HCV-1 infected patients.
Self-monitoring of Blood Glucose in a Multiethnic Population of Rural Older Adults With Diabetes

Purpose The purpose of the study was to describe self-monitoring of blood glucose (SMBG) practices of 698 older adults with type 2 diabetes in the rural Southeast, to identify characteristics differentiating testers from nontesters, and to identify personal and support-related predictors of monitoring frequency. Methods The ELDER (Evaluating Long-term Diabetes Selfmanagement Among Elderly Rural Adults) study was a population-based, cross-sectional survey of African American, Native American, and white Medicare recipients = 65 years with diagnosed diabetes. Data were obtained through in-home interviews. Multiple logistic regression models were used to identify factors associated with SMBG and frequency of monitoring. Results Seventy-seven percent of respondents practiced SMBG in the previous week; 40% tested every day in that week. No ethnic differences were seen. Significant independent predictors of any SMBG were medication regimen (taking oral agents or insulin with or without oral agents) and health care provider (HCP) recommendation to test. Among those monitoring, significant independent predictors of SMBG frequency were medication regimen, HCP recommendation to test, duration of diabetes, and receiving help with testing, which was negatively associated with monitoring frequency. Conclusions Among rural older persons with diabetes, HCP recommendation significantly affected practicing SMBG and SMBG frequency. These findings suggest points of intervention by diabetes educators with this vulnerable population. Further research is needed to determine how older adults use SMBG data in their self-care regimen.
Toll/Interleukin-1 Receptor Domain-Containing Adapter Inducing Interferon-β Mediates Microglial Phagocytosis of Degenerating Axons

Following CNS injury, microglial phagocytosis of damaged endogenous tissue is thought to play an important role in recovery and regeneration. Previous work has focused on delineating mechanisms of clearance of neurons and myelin. Little, however, is known of the mechanisms underlying phagocytosis of axon debris. We have developed a novel microfluidic platform that enables coculture of microglia with bundles of CNS axons to investigate mechanisms of microglial phagocytosis of axons. Using this platform, we find that axon degeneration results in the induction of type-1 interferon genes within microglia. Pharmacologic and genetic disruption of Toll/interleukin-1 receptor domain-containing adapter inducing interferon-β (TRIF), a Toll-like receptor adapter protein, blocks induction of the interferon response and inhibits microglial phagocytosis of axon debris in vitro. In vivo, microglial phagocytosis of axons following dorsal root axotomy is impaired in mice in which TRIF has been genetically deleted. Furthermore, we identify the p38 mitogen-activated protein kinase (MAPK) cascade as a signaling pathway downstream of TRIF following axon degeneration and find that inhibition of p38 MAPK by SB203580 (4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole) also blocked clearance of axon debris. Finally, we find that TRIF-dependent microglial clearance of unmyelinated axon debris facilitates axon outgrowth. Overall, we provide evidence that TRIF-mediated signaling plays an unexpected role in axonal debris clearance by microglia, thereby facilitating a more permissive environment for axonal outgrowth. Our study has significant implications for the development of novel regenerative and restorative strategies for the many traumatic, neuroinflammatory, and neurodegenerative conditions characterized by CNS axon degeneration.
Residual Kidney Function: Implications in the Era of Personalized Medicine

The association of residual kidney function (RKF) with improved outcomes in peritoneal dialysis and hemodialysis patients is now widely recognized. RKF provides substantial volume and solute clearance even after dialysis initiation. In particular, RKF provides clearance of nonurea solutes, many of which are potential uremic toxins and not effectively removed by conventional hemodialysis. The presence of RKF provides a distinct advantage to incident dialysis patients and is an opportunity for nephrologists to individualize dialysis treatments tailored to their patients’ unique solute, volume, and quality of life needs. The benefits of RKF present the opportunity to personalize the management of uremia.
From Policy to Practice: Tobacco Use Cessation for Employees in the Veterans Health Administration

Objective: To describe a comprehensive approach to increase tobacco use cessation in the Veterans Health Administration (VHA) employee population. Methods: The approach included: 1) national policy; 2) a pilot tobacco use cessation program; and 3) two operational surveys to assess system-wide tobacco use cessation service provision. Results: The proportion of VHA facilities offering a comprehensive tobacco use cessation program increased from 51% in 2010 to 72% in 2014, with 83% of facilities providing nicotine replacement therapy to employees. The WIN by Quitting Tobacco program was successful; employees who participated in the pilot program quit tobacco at high rates (64% at 1 month post quit date). Conclusions: From policy to practice, the comprehensive approach to tobacco use cessation in VHA was successful and may serve as a model for future workplace health promotion and occupational safety and health initiatives.
Magnitude of Anemia in Geriatric Population Visiting Outpatient Department at the University of Gondar Referral Hospital, Northwest Ethiopia: Implication for Community-Based Screening

Objective This study is aimed at assessing the magnitude and its associated factors of anemia in geriatric population visiting outpatient department at the University of Gondar referral hospital, northwest Ethiopia. Method A cross-sectional study was conducted among elder patients in Gondar town, North Gondar District, in May 2013. A total of 200 randomly selected geriatric population participated in the study. Summary statistics were computed and presented in tables and figure. Both bivariate and multivariable binary logistic regression were fitted to identify associated factors. A P value < 0.05 was considered as statistically significant. Result The median age of the study participants was 65 years (Interquartile range (IQR): 8 years). The prevalence of anemia in the geriatric patients was 54.5% (n = 109), of which 61.5% (n = 67) were males. Mild type anemia was predominant, 55.96% (n = 61). Geriatric patients with an elevated erythrocyte sedimentation rate (AOR = 9.04, 95% CI: 4.2–19.7) and who are vegetarians (AOR = 2.2, 95% CI: 1.03–4.71) were at high risk of developing anemia. Conclusion The magnitude of anemia was high in geriatrics. Mild anemia was the predominant type. Vegetarians and geriatrics with elevated erythrocyte sedimentation rate were more likely to develop anemia. Hence, early diagnosis and management of anemia have paramount importance to prevent adverse outcomes in geriatrics.
De-cloaking Malicious Activities in Smartphones Using HTTP Flow Mining

Android malware steals users’ private information, and embedded unsafe advertisement (ad) libraries, which execute unsafe code causing damage to users. The majority of such traffic is HTTP and is mixed with other normal traffic, which makes the detection of malware and unsafe ad libraries a challenging problem. To address this problem, this work describes a novel HTTP traffic flow mining approach to detect and categorize Android malware and unsafe ad library. This work designed AndroCollector, which can automatically execute the Android application (app) and collect the network traffic traces. From these traces, this work extracts HTTP traffic features along three important dimensions: quantitative, timing, and semantic and use these features for characterizing malware and unsafe ad libraries. Based on these HTTP traffic features, this work describes a supervised classification scheme for detecting malware and unsafe ad libraries. In addition, to help network operators, this work describes a fine-grained categorization method by generating fingerprints from HTTP request methods for each malware family and unsafe ad libraries. This work evaluated the scheme using HTTP traffic traces collected from 10778 Android apps. The experimental results show that the scheme can detect malware with 97% accuracy and unsafe ad libraries with 95% accuracy when tested on the popular third-party Android markets.
UNIVERSIDADE ESTADUAL PAULISTA - UNESP FACULDADE DE ODONTOLOGIA DE ARARAQUARA

ARAUJO, T.S. B. Marginal leakage in cavities of class V. Adhesive system effect, cavity preparation. 2005. 144p. Tese (Doutorado em Dentistica Restauradora) Faculdade de Odontologia, Universidade Estadual Paulista, Araraquara, 2005.
Network of breathing. Multifunctional role of the diaphragm: a review. Response to the letter to Editor of Prof. Bordoni.

www.journals. viamedica.pl Address for correspondence: Janusz Kocjan, Chair and Department of Thoracic Surgery, Faculty of Medicine and Dentistry, Medical University of Silesia, Katowice, Poland, e-mail: j_kocjan@wp.pl DOI: 10.5603/ARM.2017. 0048 Received: 03.11. 2017 Copyright © 2017 PTChP ISSN 2451–4934 Janusz Kocjan, Mariusz Adamek, Bożena Gzik-Zroska, Damian Czyżewski, Mateusz Rydel Chair and Department of Thoracic Surgery, Faculty of Medicine and Dentistry, Medical University of Silesia, Katowice, Poland Department of Biomaterials and Medical Devices Engineering, Silesian University of Technology, Zabrze, Poland
Robust video watermarking algorithm for H.264/AVC based on JND model

With the purpose of copyright protection for digital video, a novel H.264/AVC watermarking algorithm based on JND model is proposed. Firstly, according to the characteristics of human visual system, a new and more accurate JND model is proposed to determine watermark embedding strength by considering the luminance masking, contrast masking and spatial frequency sensitivity function. Secondly, a new embedding strategy for H.264/AVC watermarking is proposed based on an analysis on the drift error of energy distribution. We argue that more robustness can be achieved if watermarks are embedded in middle and high components of 4×4 integer DCT since these components are more stable than dc and low components when drift error occurs. Finally, according to different characteristics of middle and high components, the watermarks are embedded using different algorithms, respectively. Experimental results demonstrate that the proposed watermarking algorithm not only meets the imperceptibility and robustness requirements, but also has a high embedding capacity.
Apathy Profile in Parkinson’s and Huntington’s Disease: A Comparative Cross-Sectional Study

Background/Aims: Apathy is one of the most frequent, disabling and difficult-to-treat symptoms that show up in many neurodegenerative disorders. The aim of this study was to assess and compare apathy profile in Parkinson’s and Huntington’s patients using the same comprehensive instruments to measure apathy, cognition and depressive symptoms. Materials and Methods: We consecutively assessed Parkinson’s disease (PD) and Huntington’s disease (HD) patients recruited from a Movement Disorders Unit. In all patients, information related to demographics, clinical data, motor score (Movement Disorders Society-Unified Parkinson Disease Rating Scale; Unified Huntington Disease Rating Scale), cognition (Montreal Cognitive Assessment scale), depressive symptoms (Beck Depression Inventory II) and apathy (Apathy Evaluation Scale – clinical version) was collected. Patients with dementia or major depression according to Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revised criteria were excluded from the study. Results: Seventy-five patients were enrolled, 45 with PD and 30 with HD. Apathy was present in 42.5% of PD patients and 51.7% of HD patients. In PD patients, apathy was associated with motor score, shorter duration of disease, lower dose of levodopa equivalent daily dose and depressive symptomatology, whereas in HD patients, apathy was related to disease duration, motor score and cognitive impairment. Conclusions: We found a similar prevalence of apathy in PD and HD patients but with different clinical correlations and different apathy domains involved, and this may warrant the development of different therapeutic approaches.
Effects of Cognitive Distortions on the Link Between Dating Violence Exposure and Substance Problems in Clinically Hospitalized Youth.

PURPOSE The purpose of the present study was to examine whether cognitive distortions (e.g., cognitive errors; negative views of self, world, and future) influence the association between dating violence and problematic substance use behaviors in a sample of psychiatrically hospitalized adolescents. METHOD Participants included 155 adolescents, aged 13-17 years, who had initiated dating. Adolescents completed measures of dating violence, substance-related problems (alcohol and marijuana), and cognitive distortions. RESULTS Logistic regressions were conducted to examine the direct and interactive effects of dating violence exposure and cognitive distortions on likelihood of recent problematic substance use. Results suggested a main effect of dating violence on problematic alcohol and other drug use as well as an interactive effect of dating violence and cognitive distortions. Specifically, the relationship between dating violence and odds of substance-related problems was higher among those with greater (vs. fewer) cognitive distortions. CONCLUSION Study results suggest the need for careful screening of cognitive distortions among adolescent dating violence victims, particularly those in mental health treatment.
Phosphatase Rtr1 Regulates Global Levels of Serine 5 RNA Polymerase II C-Terminal Domain Phosphorylation and Cotranscriptional Histone Methylation

ABSTRACT In eukaryotes, the C-terminal domain (CTD) of Rpb1 contains a heptapeptide repeat sequence of (Y1S2P3T4S5P6S7)n that undergoes reversible phosphorylation through the opposing action of kinases and phosphatases. Rtr1 is a conserved protein that colocalizes with RNA polymerase II (RNAPII) and has been shown to be important for the transition from elongation to termination during transcription by removing RNAPII CTD serine 5 phosphorylation (Ser5-P) at a selection of target genes. In this study, we show that Rtr1 is a global regulator of the CTD code with deletion of RTR1 causing genome-wide changes in Ser5-P CTD phosphorylation and cotranscriptional histone H3 lysine 36 trimethylation (H3K36me3). Using chromatin immunoprecipitation and high-resolution microarrays, we show that RTR1 deletion results in global changes in RNAPII Ser5-P levels on genes with different lengths and transcription rates consistent with its role as a CTD phosphatase. Although Ser5-P levels increase, the overall occupancy of RNAPII either decreases or stays the same in the absence of RTR1. Additionally, the loss of Rtr1 in vivo leads to increases in H3K36me3 levels genome-wide, while total histone H3 levels remain relatively constant within coding regions. Overall, these findings suggest that Rtr1 regulates H3K36me3 levels through changes in the number of binding sites for the histone methyltransferase Set2, thereby influencing both the CTD and histone codes.