Miracle-dz/UniFAR-FTUs huggingface dataset:
Possible Link between Medical Students' Motivation for Academic Work and Time Engaged in Physical Exercise.

Physical exercise results in an active well-being. It is likely that students' engagement in physical exercise keeps them motivated to perform academic endeavors. This study aimed to assess the relation of time engaged in physical exercise with medical students' motivation for academic work. Prospectively, 296 second-year medical students self-administered Vallerand's Academic Motivation Scale. The frequency of exercise per week and the duration per time were multiplied to compute a weekly physical exercise engagement time. Multivariable regression model treated the intrinsic motivation construct as the dependent variable, adjusting relevant covariates such as sleeping time, sitting time, screen time, and vegetable intake. The level of intrinsic motivation was positively related to the student's physical exercise time per week (β 0.85, 95% confidence interval 0.42–1.26, p-value < 0.001). Thus, generating conditions in which students can engage in physical exercise may contribute to fostering their intrinsic motivation for academic work.
Trend and Risk Factors of Diverticulosis in Japan: Age, Gender, and Lifestyle/Metabolic-Related Factors May Cooperatively Affect on the Colorectal Diverticula Formation

Background Despite the marked increase of diverticulosis, its risk factors have not been adequately elucidated. We therefore aim to identify significantly associated factors with diverticulosis. We also aim to investigate the present state of diverticulosis in Japan. Methods We reviewed the medical records from 1990 to 2010 that included the data of consecutive 62,503 asymptomatic colonoscopy examinees from the general population in Japan. Most recent 3,327 examinees were analyzed with 16 background factors. Results Among the 62,503 subjects (47,325 men and 15,178 women; 52.1 ± 9.2 years old), diverticulosis was detected in 11,771 subjects (18.8%; 10,023 men and 1,748 women). The incidences of diverticulosis in 1990-2000 and 2001-2010 were respectively 13.0% (3,771 of 29,071) and 23.9% (8,000 of 33,432): the latter was much higher than the former in all age groups and for both genders. Considering the anatomical locations of colorectal diverticula, left-sided ones have markedly increased with age but not significantly changed with times. Univariate analyses of the 3,327 subjects showed significant association of diverticulosis with four basic factors (age, sex, body mass index, blood pressure), three life style-related factor (smoking, drinking, severe weight increase in adulthood), and two blood test values (triglyceride, HbA1c). The multiple logistic analysis calculating standardized coefficients (β) and odds ratio (OR) demonstrated that age (β = 0.217-0.674, OR = 1.24-1.96), male gender (β = 0.185, OR = 1.20), smoking (β = 0.142-0.200, OR = 1.15-1.22), severe weight increase in adulthood (β = 0.153, OR = 1.17), HbA1c (β = 0.136, OR = 1.15), drinking (β = 0.109, OR = 1.11), and serum triglyceride (β = 0.098, OR = 1.10) showed significantly positive association with diverticulosis whereas body mass index and blood pressure did not. Conclusions The large-scale data of asymptomatic colonoscopy examinees from the general population from 1990 to 2010 indicated that the prevalence of diverticulosis is still increasing in Japan. Age, male gender, smoking, severe weight increase in adulthood, serum HbA1c, drinking, and serum triglyceride showed significant positive association with diverticulosis.
Alignment by phase of vertical coefficients in SA-DCT

In this paper, we introduce a formula to align the vertical coefficients of the SA-DCT (shape-adaptive discrete cosine transform). Instead of grouping coefficients with the same index as proposed by Sikora and Makai (1995), the new method employs an alignment by phase strategy. Experimental results are given for both synthetic segments and real testing image sequences.
Opioids are responsible for neurochemical feminization of the brain in prenatally stressed male rats.

OBJECTIVES To study the role of opioids in early postnatal changes of the hypothalamic testosterone metabolism and catecholamine content underlying feminizing effect of prenatal stress on male sexual behavior in rats. MATERIAL AND METHODS 10 day-old male and female offspring from mothers given naltrexone prior to daily 1-hour restraint during the last gestational week were used in the study. Aromatase and 5 alpha-reductase activities, noradrenaline and dopamine contents in the brain preoptic area and medial basal hypothalamus were studied by thin layer chromatography, radiometric and spectrofluorimetric techniques. RESULTS Sexual dimorphism of testosterone metabolism enzymes activity and catecholamine content in discrete brain regions of 10 day-old rat pups was found. Prenatal stress attenuated these gender-related differences. Naltrexone pre-treatment of stressed dams prevented modifying effect of prenatal stress on aromatase activity and noradrenaline content in the male preoptic area. CONCLUSIONS The results of the study demonstrate preventive effect of naltrexone on stress-induced alterations of testosterone aromatization and noradrenaline concentration in the developing brain preoptic area associated with neuroendocrine control of the male sexual behavior in adult rats. These findings indicate that endogenic opioids mediate detrimental effect of prenatal stress on neurochemical determinants of the brain sexual differentiation that may underlie feminization of the male sexual behavior.
Dual role for Jumu in the control of hematopoietic progenitors in the Drosophila lymph gland

The Drosophila lymph gland is a hematopoietic organ in which the maintenance of hematopoietic progenitor cell fate relies on intrinsic factors and extensive interaction with cells within a microenvironment. The posterior signaling center (PSC) is required for maintaining the balance between progenitors and their differentiation into mature hemocytes. Moreover, some factors from the progenitors cell-autonomously control blood cell differentiation. Here, we show that Jumeau (Jumu), a member of the forkhead (Fkh) transcription factor family, controls hemocyte differentiation of lymph gland through multiple regulatory mechanisms. Jumu maintains the proper differentiation of prohemocytes by cell-autonomously regulating the expression of Col in medullary zone and by non-cell-autonomously preventing the generation of expanded PSC cells. Jumu can also cell-autonomously control the proliferation of PSC cells through positive regulation of dMyc expression. We also show that a deficiency of jumu throughout the lymph gland can induce the differentiation of lamellocytes via activating Toll signaling. DOI: http://dx.doi. org/10.7554/eLife.25094. 001
Fibre bundle formulation of relativistic quantum mechanics. II. Covariant approach

We propose a fibre bundle formulation of the mathematical base of relativistic quantum mechanics. At the present stage the bundle form of the theory is equivalent to its conventional one, but it admits new types of generalizations in different directions. In the present, second, part of our investigation, we consider a covariant approach to bundle description of relativistic quantum mechanics. In it the wavefunctions are replaced with (state) sections of a suitably chosen vector bundle over space-time whose (standard) fibre is the space of the wavefunctions. Now the quantum evolution is described as a linear transportation (by means of the transport along the identity map of the space\nobreakdash-time) of the state sections in the (total) bundle space. Connections between the (retarded) Green functions of the relativistic wave equations and the evolution operators and transports are found. Especially the Dirac and Klein-Gordon equations are considered.
The new fern genus Calciphilopteris (Pteridaceae)

A new genus of Pteridaceae subfamily Cheilanthoideae is established for what has long been known as Doryopteris ludens. The newly erected genus is named Calciphilopteris in reference to its substrate specificity to limestone. Calciphilopteris can be found throughout Southeast Asia, from Indo-China to New Guinea and Australia. New combinations are established for the four known species (Calciphilopteris alleniae, C. ludens, C. papuana and C. wallichii). Calciphilopteris is characterized by having a horizontal rhizome, semi-clathrate scales, indumentum on the petiole and lamina usually with fibrils and/or semi- to non-clathrate scales, and sporangia with 32 echinate or cristate spores.
Thin-ice dynamics and ice production in the Storfjorden polynya for winter seasons 2002/2003-2013/2014 using MODIS thermal infrared imagery

Abstract. Spatial and temporal characteristics of the Storfjorden polynya, which forms regularly in the proximity of the islands Spitsbergen, Barentsoya and Edgeoya in the Svalbard archipelago under the influence of strong northeasterly winds, have been investigated for the period of 2002/2003 to 2013/2014 using thermal infrared satellite imagery. Thin-ice thicknesses were calculated from MODIS ice-surface temperatures combined with ECMWF ERA-Interim atmospheric reanalysis data in an energy-balance model. Associated quantities like polynya area and total ice production were derived and compared to previous remote sensing and modeling studies. A basic coverage-correction scheme was applied to account for cloud gaps in the daily composites. On average, both polynya area and ice production are thereby increased by about 30%. The sea ice in the Storfjorden area experiences a late fall freeze-up in several years over the 12-winter period, which becomes most apparent through an increasing frequency of large thin-ice areas until the end of December. In the course of an average winter season, ice thicknesses below 10 cm are dominating within the Storfjorden basin. During the regarded period, the mean polynya area is 4555.7 ± 1542.9 km2. Maximum daily ice production rates can reach as high as 26 cm d−1, while the average ice production is estimated at 28.3 ± 8.5 km3 per winter and therefore lower than in previous studies. Despite this comparatively short record of 12 winter seasons, a significant positive trend of 20.2 km3 per decade could be detected, which originates primarily from a delayed freeze-up in November and December in recent winter seasons. This contrasts earlier reports of a slightly negative trend in accumulated ice production prior to 2002. Although featuring more pronounced interannual variations between 2004/2005 and 2011/2012, our estimates underline the importance of this relatively small coastal polynya system considering its contribution to the cold halocline layer through salt release during ice-formation processes. In addition, calculated quasi-daily thin-ice thickness charts represent a valuable data set for atmosphere and ocean modeling applications.
A Systematic Survey of Loss-of-Function Variants in Human Protein-Coding Genes

Defective Gene Detective Identifying genes that give rise to diseases is one of the major goals of sequencing human genomes. However, putative loss-of-function genes, which are often some of the first identified targets of genome and exome sequencing, have often turned out to be sequencing errors rather than true genetic variants. In order to identify the true scope of loss-of-function genes within the human genome, MacArthur et al. (p. 823; see the Perspective by Quintana-Murci) extensively validated the genomes from the 1000 Genomes Project, as well as an additional European individual, and found that the average person has about 100 true loss-of-function alleles of which approximately 20 have two copies within an individual. Because many known disease-causing genes were identified in “normal” individuals, the process of clinical sequencing needs to reassess how to identify likely causative alleles. Validation of predicted nonfunctional alleles in the human genome affects the medical interpretation of genomic analyses. Genome-sequencing studies indicate that all humans carry many genetic variants predicted to cause loss of function (LoF) of protein-coding genes, suggesting unexpected redundancy in the human genome. Here we apply stringent filters to 2951 putative LoF variants obtained from 185 human genomes to determine their true prevalence and properties. We estimate that human genomes typically contain ~100 genuine LoF variants with ~20 genes completely inactivated. We identify rare and likely deleterious LoF alleles, including 26 known and 21 predicted severe disease–causing variants, as well as common LoF variants in nonessential genes. We describe functional and evolutionary differences between LoF-tolerant and recessive disease genes and a method for using these differences to prioritize candidate genes found in clinical sequencing studies.
Participatory Simulations: Building Collaborative Understanding Through Immersive Dynamic Modeling

This article explores a new way to help people understand complex, dynamic systems. Participatory simulations plunge learners into life-sized, computer-supported simulations, creating new paths to scientific understanding. By wearing small, communicating computers called Thinking Tags, students are transformed into players in a large-scale microworld. Like classic microworlds, participatory simulations create a scenario, mediated by a set of underlying rules, that enables inquiry and experimentation. In addition, these new activities allow students to "dive into" a learning environment and directly engage with the complex system at hand. This article describes and analyzes a set of participatory simulations that were conducted with a group of high school biology students. The students' experiences are tracked from their initial encounter with an immersive simulation through their exploration of the system and final description of its underlying rules. The article explores the educational potential of participatory simulations. The results of this pilot study suggest an opportunity to further investigate the role that personal experience can play in developing inquiry skills and scientific understanding.
Proteomic Analysis of the Systemic Immune Response of Drosophila*

Improvements in two-dimensional gel electrophoresis, mass spectrometry, and bioinformatics provide new tools to characterize proteins involved in a physiological process, such as the immune response of the insect model Drosophila melanogaster. Profiling of the proteins present in the hemolymph (insect blood) of noninfected flies versus flies infected with bacteria or fungi was performed by two-dimensional gel electrophoresis, silver or Coomassie staining, and image analysis. Through this differential analysis, more than 70 out of 160 spots were up- or down-regulated by at least 5-fold after microbial infection. Coomassie staining, in-gel digestion, and database searches yielded the identity of a series of proteins that are directly involved in the Drosophila immune system. This included proteases, protease inhibitors, and recognition molecules such as prophenoloxydase-activating enzymes, serpins, and Gram-negative binding protein-like. Proteins with a potential function in the immune response were also identified, such as an odorant binding protein, peptidylglycine α-hydroxylating monooxygenase, and transferrin, affording new candidates for further investigation of innate immune mechanisms. Moreover, several molecules resulting from the cleavage of proteins were detected after the fungal infection. Altogether, this first differential proteomic analysis of the immune response of Drosophila paves the way for the study of proteins affected during innate immunity.
Neural Activity Associated with the Passive Prediction of Ambiguity and Risk for Aversive Events

In economic decision making, outcomes are described in terms of risk (uncertain outcomes with certain probabilities) and ambiguity (uncertain outcomes with uncertain probabilities). Humans are more averse to ambiguity than to risk, with a distinct neural system suggested as mediating this effect. However, there has been no clear disambiguation of activity related to decisions themselves from perceptual processing of ambiguity. In a functional magnetic resonance imaging (fMRI) experiment, we contrasted ambiguity, defined as a lack of information about outcome probabilities, to risk, where outcome probabilities are known, or ignorance, where outcomes are completely unknown and unknowable. We modified previously learned pavlovian CS+ stimuli such that they became an ambiguous cue and contrasted evoked brain activity both with an unmodified predictive CS+ (risky cue), and a cue that conveyed no information about outcome probabilities (ignorance cue). Compared with risk, ambiguous cues elicited activity in posterior inferior frontal gyrus and posterior parietal cortex during outcome anticipation. Furthermore, a similar set of regions was activated when ambiguous cues were compared with ignorance cues. Thus, regions previously shown to be engaged by decisions about ambiguous rewarding outcomes are also engaged by ambiguous outcome prediction in the context of aversive outcomes. Moreover, activation in these regions was seen even when no actual decision is made. Our findings suggest that these regions subserve a general function of contextual analysis when search for hidden information during outcome anticipation is both necessary and meaningful.
Connecting on Movie Night? Neural Measures of Engagement Differ By Gender

We propose a novel method, Cross Brain Correlation (CBC), to study between-group differences in responses to complex stimuli, such as movies or advertisements, based on agreement across multiple brains while experiencing content. Clustering this neural data (i.e. segmentation by gender) can distill preferences that are not captured by traditional means.
Spinal analgesia improves surgical outcome after open nephrectomy for renal cell carcinoma: a randomized controlled study

Abstract Objective: This study evaluated whether more effective perioperative analgesia can be part of a multimodal approach to minimizing morbidity and improving postoperative management after the open surgical approaches frequently used in the treatment of renal cell carcinoma (RCC). The aim of the study was to determine whether spinal anesthesia with clonidine can enhance postoperative analgesia, speed up mobilization and reduce the length of hospital stay (LOS). Materials and methods: Between 2012 and 2015, 135 patients with RCC were randomized, in addition to general anesthesia, to receive either spinal analgesia with clonidine or epidural analgesia, stratified to surgical technique. Inclusion criteria were American Society of Anesthesiologists (ASA) score of III or less, age over 18 years and no chronic pain medication or cognitive disorders. Results: The median LOS was 4 days for patients in the spinal group and 6 days in the epidural group (p = 0.001). There were no differences regarding duration of surgery, blood loss, RENAL score, tumor size or complications between the given analgesia methods. A limitation was that different anesthesiologists were responsible for administering spinal or epidural anesthesia, as in a real-world clinical situation. Conclusions: In this randomized controlled study, spinal analgesia with clonidine was superior to continuous epidural analgesia in patients operated on with open nephrectomy, based on shorter LOS. A shorter LOS in the study group indicates faster mobilization and improved analgesia. Spinal analgesia did not carry more complications than epidural analgesia.
CONTACT: arbitrary in-between motions for collision detection

A new approach to the collision detection problem was introduced previously by the authors (2000), that allows one to detect collisions continuously and efficiently between polyhedral primitives (vertices, edges and faces). This paper extends the previous results to continuously detect collisions between pairs of complex polyhedral objects. A C++ library, CONTACT, is developed. The tests of this library reported show that this approach is especially suited for a precise real-time interaction in virtual environments.
Modes Of Thought Explorations In Culture And Cognition

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Population Genomic Scan for Candidate Signatures of Balancing Selection to Guide Antigen Characterization in Malaria Parasites

Acquired immunity in vertebrates maintains polymorphisms in endemic pathogens, leading to identifiable signatures of balancing selection. To comprehensively survey for genes under such selection in the human malaria parasite Plasmodium falciparum, we generated paired-end short-read sequences of parasites in clinical isolates from an endemic Gambian population, which were mapped to the 3D7 strain reference genome to yield high-quality genome-wide coding sequence data for 65 isolates. A minority of genes did not map reliably, including the hypervariable var, rifin, and stevor families, but 5,056 genes (90.9% of all in the genome) had >70% sequence coverage with minimum read depth of 5 for at least 50 isolates, of which 2,853 genes contained 3 or more single nucleotide polymorphisms (SNPs) for analysis of polymorphic site frequency spectra. Against an overall background of negatively skewed frequencies, as expected from historical population expansion combined with purifying selection, the outlying minority of genes with signatures indicating exceptionally intermediate frequencies were identified. Comparing genes with different stage-specificity, such signatures were most common in those with peak expression at the merozoite stage that invades erythrocytes. Members of clag, PfMC-2TM, surfin, and msp3-like gene families were highly represented, the strongest signature being in the msp3-like gene PF10_0355. Analysis of msp3-like transcripts in 45 clinical and 11 laboratory adapted isolates grown to merozoite-containing schizont stages revealed surprisingly low expression of PF10_0355. In diverse clonal parasite lines the protein product was expressed in a minority of mature schizonts (<1% in most lines and ∼10% in clone HB3), and eight sub-clones of HB3 cultured separately had an intermediate spectrum of positive frequencies (0.9 to 7.5%), indicating phase variable expression of this polymorphic antigen. This and other identified targets of balancing selection are now prioritized for functional study.