Miracle-dz/UniFAR-FTUs huggingface dataset:
Logical Concurrency Control from Sequential Proofs

We are interested in identifying and enforcing the isolation requirements of a concurrent program, i.e., concurrency control that ensures that the program meets its specification. The thesis of this paper is that this can be done systematically starting from a sequential proof, i.e., a proof of correctness of the program in the absence of concurrent interleavings. We illustrate our thesis by presenting a solution to the problem of making a sequential library thread-safe for concurrent clients. We consider a sequential library annotated with assertions along with a proof that these assertions hold in a sequential execution. We show how we can use the proof to derive concurrency control that ensures that any execution of the library methods, when invoked by concurrent clients, satisfies the same assertions. We also present an extension to guarantee that the library is linearizable with respect to its sequential specification.
Additional modules for versatile and economical PCR‐based gene deletion and modification in Saccharomyces cerevisiae

An important recent advance in the functional analysis of Saccharomyces cerevisiae genes is the development of the one‐step PCR‐mediated technique for deletion and modification of chromosomal genes. This method allows very rapid gene manipulations without requiring plasmid clones of the gene of interest. We describe here a new set of plasmids that serve as templates for the PCR synthesis of fragments that allow a variety of gene modifications. Using as selectable marker the S. cerevisiae TRP1 gene or modules containing the heterologous Schizosaccharomyces pombe his5+ or Escherichia coli kanr gene, these plasmids allow gene deletion, gene overexpression (using the regulatable GAL1 promoter), C‐ or N‐terminal protein tagging [with GFP(S65T), GST, or the 3HA or 13Myc epitope], and partial N‐ or C‐terminal deletions (with or without concomitant protein tagging). Because of the modular nature of the plasmids, they allow efficient and economical use of a small number of PCR primers for a wide variety of gene manipulations. Thus, these plasmids should further facilitate the rapid analysis of gene function in S. cerevisiae. © 1998 John Wiley & Sons, Ltd.
Failure to Return for Posttest Counseling and HIV Test Results at the Prevention and Voluntary Testing and Counseling Centers of Douala, Cameroon: An Evaluation of a Routine Five-Year Program

This study examined the magnitude and time trends in failure to return (FTR) rates and the relation between FTR and individual characteristics, tests procedures, waiting period for the results, and HIV test results among people who were screened for HIV in the prevention and voluntary testing and counseling centers (PVTCCs) of six district hospitals of the city of Douala in Cameroon, between January 2009 and December 2013. It was a retrospective analysis of medical records. Among the 32,020 analyzed records, the failure to return (FTR) rate was 14.3%. Overall, people aged 50 years and over, those tested between 2011 and 2012, and those tested in the PVTCC of Bonassama were less likely to return for their results. Significant factors associated with FTR included being a housewife, having a positive/undetermined/requiring confirmation result, and provider-initiated testing and counseling (PITC). There was an increasing trend for FTR in the PVTCCs of Bonassama, New-Bell, Nylon, and Cité des Palmiers. HIV testing and counseling services in Douala district hospitals must be reorganized such that individuals tested for HIV receive their results on the same day of the test. Also counselors need to better alert clients concerning the importance of returning for their test results.
Radiation effects on samarium-cobalt permanent magnets

With the recent advances in rare-earth-cobalt (REC) permanent magnet technology, new applications are being implemented that were previously not feasible. One such application is the use of permanent magnetic lenses for accelerator and beam transport systems. In many of these areas the magnetic transport systems are subjected to high radiation levels. Consequently, there is considerable interest in the United States and abroad in the possible changes in the magnetic field when subjected to radiation. This is a description of our approach in performing the field measurements before and after irradiating samples of samarium-cobalt permanent magnets.
The Benefits of Relationship Lending in a Cross-Country Context: A Meta-Analysis

Relationship lending may create benefits for borrowers by reducing information asymmetries. However, empirical evidence is mixed. We conduct a meta-analysis to summarize and explain the heterogeneity in the results in the literature using hand-collected information from 101 studies in the United States, Europe, Asia, and Latin America from 1970 to 2010. We find that strong relationships are generally beneficial for borrowers, but lending outcomes differ across the relationships’ dimensions. Long-lasting, exclusive, and synergy-creating bank relationships are associated with higher credit volume and lower loan rates. These benefits are more likely in the United States and in countries where bank competition is high. They are not related to the importance of small and medium-sized enterprises in an economy, suggesting that prevalence of relationship lending does not necessarily come along with borrower benefits. Our inferences are robust when we control for observed systematic heterogeneity in the original studies and hold in a bootstrapping analysis.Data, as supplemental material, are available at http://dx.doi. org/10.1287/mnsc.2014. 2088 . This paper was accepted by Wei Jiang, finance .
Patch sparsity based image inpainting using local patch statistics and steering kernel descriptor

This paper presents a sparse representation based image inpainting method using local patch analysis and geometric structure based feature extraction. In local patch analysis, we approximate the target region by weighted average of some local patches which are frequently occurred within a neighborhood. Local patch statistics is applied to find the most relevant neighbors for each target patch. Further we extract local steering kernel (LSK) based feature to preserve geometric structure and texture sharpness in the target region. The advantage of non local self similarity as redundancy of similar patches in natural images is introduced to find the candidate patches from the whole source region. Based on these local and non local prior information we propose a sparse representation framework for image inpainting. Our proposed method is tested on wide range of natural images. The experimental results show the superiority of the proposed method compared to some of the previous approaches.
Sensitivity and specificity in detection of labral tears with 3.0-T MRI of the shoulder.

OBJECTIVE MRI of the shoulder has been found to be sensitive and specific for detection of labral tears at 1.5 T or lower field strength compared with arthroscopy, whereas 3.0-T MRI of the shoulder has not been specifically assessed. This study assesses the sensitivity and specificity of MRI at 3.0 T for labral tears compared with arthroscopy. CONCLUSION MRI of the shoulder at 3.0 T is very sensitive and specific compared with arthroscopy in detection of superior, anterior, and posterior labral tears.
Investigation of the Tool Wear Rate in Tungsten Powder-Mixed Electric Discharge Machining of AA6061/10%SiCp Composite

This paper presents the experimental investigation on tool wear rate (TWR) in powder-mixed electrical discharge machining (PMEDM) of aluminum 6061 alloy reinforced with 10% silicon carbide particles (AA6061/10%SiCp composite). Composite material is fabricated by mechanical stir casting process and further characterized by scanning electron microscope (SEM) and energy dispersive spectroscopy (EDS). Tungsten powder with concentration of 4 g/L is mixed in the dielectric fluid. To know the influence of powder suspension in dielectric fluid on TWR, comparative study is done on the basis of experiments performed using basic EDM and PMEDM process. Experiments have been designed as per central composite rotatable design (CCRD) using response surface methodology (RSM) approach. Four process parameters, namely, peak current, pulse-on time, pulse-off time, and gap voltage have been considered for TWR investigation. Individual and interactive influence of various parameters on TWR is explained with the help of analysis of variance and three-dimensional graphs. Using RSM approach, results have been further optimized. PMEDM approach provides 51.12% reduction in TWR for machining of AA6061/10%SiCp composite.
Spermine Synthesis Is Required for Normal Viability, Growth, and Fertility in the Mouse*

Spermidine is essential for viability in eukaryotes but the importance of the longer polyamine spermine has not been established. Spermine is formed from spermidine by the action of spermine synthase, an aminopropyltransferase, whose gene (SpmS) is located on the X chromosome. Deletion of part of the X chromosome that include SpmS in Gy mice leads to a striking phenotype in affected males that includes altered phosphate metabolism and symptoms of hypophosphatemic rickets, circling behavior, hyperactivity, head shaking, inner ear abnormalities, deafness, sterility, a profound postnatal growth retardation, and a propensity to sudden death. It was not clear to what extent these alterations were due to the loss of spermine synthase activity, since this chromosomal deletion extends well beyond the SpmS gene and includes at least one other gene termed Phex. We have bred the Gy carrier female mice with transgenic mice (CAG/SpmS mice) that express spermine synthase from the ubiquitous CAG promoter. The resulting Gy-CAG/SpmS mice had extremely high levels of spermine synthase and contained spermine in all tissues examined. These mice had a normal life span and fertility and a normal growth rate except for a reduction in body weight due to a loss of bone mass that was consistent with the observation that the derangement in phosphate metabolism is due to the loss of the Phex gene and was not restored. These results show that spermine synthesis is needed for normal growth, viability, and fertility in male mice and that regulation of spermine synthase content is not required.
A nomogram relating pO2, pH, temperature, and hemoglobin saturation in the dog.

Abstract : The data from 591 dog blood samples on which observations were made of Po sub 2, hemoglobin saturation, Pco sub 2, pH, and temperature were analyzed by means of a digital computer. The Hill equation was found to fit the data well in the range from 20% to 98% saturation. Linear terms for pH and temperature effects were found to improve appreciably the prediction ability of the equation. A similar term for Pco sub 2, although statistically significant, did not contribute enough additional precision in prediction to justify its inclusion in the final equations. The equations derived are: log (S/1-S) = 2.5198 log Po sub 2 + 1.1804 (pH-7.0) - . 047234T - 2.3621 and log Po sub 2 = . 37143 log (S/1-S) - . 48047 (pH-7.0) + . 019518T + . 92247. A nomogram relating these variables is also presented. (Author)
Comparison of Spinal Health Indicators in Predicting Spinal Status in a 1-Year Longitudinal Study

A 1-year longitudinal study was performed to assess and compare the predictive qualities of spinal health indicators (excluding the cervical spine) among aircraft assembly workers having at least 1 year seniority in a large assembly plant. Ten health indicators were compared to determine their sensitivity and predictive power with regard to back compensation and absenteeism in 12 months follow-up, and the presence of any limitation at work due to the back, or symptoms to the back at the end of the interval. The initial response to a self-administered questionnaire was obtained from 269 male workers, of whom 205 (76.2%) completed the follow-up questionnaire. Initial prevalence of symptoms to the back was 42.3%, limitation in performing at work was 28.1%, consultation of a health professional was 7.3%, and a history of compensation for the back (ever) was reported by 30.4%. During the year of follow-up, 16 (6%) of the 269 workers initially enrolled were granted 17 compensated episodes. Of the 205 workers who responded to the follow-up, 33 (16.1%) have been absent from work (with or without compensation) because of their back. The presence, at the beginning of the study, of a limitation in performing at work or in activities of daily living and a history of compensation (ever) were the three indicators independently associated with the occurrence of compensation or absenteeism (total work disability) related to a back problem during the following year. The three indicators combined (either one positive at beginning of the study) had a sensitivity rate of 81.8% and a predictive power rate of 28.4% (predicting total work disability). These results are the best ever published for a spinal health indicator measured from a survey questionnaire. Besides acceptable predictive qualities, the combined indicator predicted work disability from predisability states. Its value for targeting interventions in industry aimed at preventing the worsening of early stages of spinal disorders toward disabling conditions, remains to be tested.
Development of a selective medium for detection and enumeration of Actinomyces viscosus and Actinomyces naeslundii in dental plaque

A selective medium (CFAT) was developed for the detection and enumeration of Actinomyces viscosus and Actinomyces naeslundii in dental plaque. Neutral acriflavin and potassium tellurite were used in combination with the known selective agents cadmium and fluoride to eliminate most of the competing plaque flora. Composition of CFAT per liter was as follows: Trypticase soy broth (BBL Microbiology Systems), 30 g; glucose, 5 g; agar, 15 g' cadmium sulfate, 13 mg; sodium fluoride, 85 mg; neutral acriflavin, 1.20 mg; potassium tellurite, 2.50 mg; basic fuchsin, 1.25 mg; defibrinated sheep blood, 50 ml. A. viscosus reference strains of human origin grew on CFAT without reduction in numbers under an atmosphere of 90% air-10% CO2. Animal strains of A. viscosus were inhibited at the level of cadmium in CFAT. Two of six A. naeslundii strains did not grow on CFAT. Improved recovery of A. viscosus and A. naeslundii from dental plaque occurred on CFAT, as compared with two other selective media which contained either cadmium sulfate or sodium fluoride, respectively, as selective agents. CFAT was more selective with regard to much of the extraneous gram-positive flora. Bacterionemia, Neisseria, yeasts, and streptococci were virtually eliminated.
Automated Dynamic Analysis of CUDA Programs

Recent increases in the programmability and performance of GPUs have led to a surge of interest in utilizing them for general-purpose computations. Tools such as NVIDIA’s Cuda allow programmers to use a C-like language to code algorithms for execution on the GPU. Unfortunately, parallel programs are prone to subtle correctness and performance bugs, and Cuda tool support for solving these remains a work in progress. As a first step towards addressing these problems, we present an automated analysis technique for finding two specific classes of bugs in Cuda programs: race conditions, which impact program correctness, and shared memory bank conflicts, which impact program performance. Our technique automatically instruments a program in two ways: to keep track of the memory locations accessed by different threads, and to use this data to determine whether bugs exist in the program. The instrumented source code can be run directly in Cuda’s device emulation mode, and any potential errors discovered will be automatically reported to the user. This automated analysis can help programmers find and solve subtle bugs in programs that are too complex to analyze manually. Although these issues are explored in the context of Cuda programs, similar issues will arise in any sufficiently “manycore” architecture.
Policies to Enhance Prescribing Efficiency in Europe: Findings and Future Implications

Introduction: European countries need to learn from each other to address unsustainable increases in pharmaceutical expenditures. Objective: To assess the influence of the many supply and demand-side initiatives introduced across Europe to enhance prescribing efficiency in ambulatory care. As a result provide future guidance to countries. Methods: Cross national retrospective observational study of utilization (DDDs – defined daily doses) and expenditure (Euros and local currency) of proton pump inhibitors (PPIs) and statins among 19 European countries and regions principally from 2001 to 2007. Demand-side measures categorized under the “4Es” – education engineering, economics, and enforcement. Results: Instigating supply side initiatives to lower the price of generics combined with demand-side measures to enhance their prescribing is important to maximize prescribing efficiency. Just addressing one component will limit potential efficiency gains. The influence of demand-side reforms appears additive, with multiple initiatives typically having a greater influence on increasing prescribing efficiency than single measures apart from potentially “enforcement. ” There are also appreciable differences in expenditure (€/1000 inhabitants/year) between countries. Countries that have not introduced multiple demand side measures to counteract commercial pressures to enhance the prescribing of generics have seen considerably higher expenditures than those that have instigated a range of measures. Conclusions: There are considerable opportunities for European countries to enhance their prescribing efficiency, with countries already learning from each other. The 4E methodology allows European countries to concisely capture the range of current demand-side measures and plan for the future knowing that initiatives can be additive to further enhance their prescribing efficiency.
Deactivation of Akt and STAT3 signaling promotes apoptosis, inhibits proliferation, and enhances the sensitivity of hepatocellular carcinoma cells to an anticancer agent, Atiprimod

Atiprimod is a novel anticancer and antiangiogenic drug candidate which is currently being evaluated in patients with liver carcinoid and multiple myeloma. In this study, we report that atiprimod selectively inhibited proliferation and induced apoptosis in HCC cells that expressed either hepatitis B virus (HBV) or hepatitis C virus, through deactivation of protein kinase B (Akt) and signal transducers and activators of transcription 3 (STAT3) signaling. In HepG2 AD38 cells, which express HBV genome under the control of a tetracycline-off promoter, both Akt and STAT3 were constitutively activated in response to HBV expression. However, this constitutive activation was not sensitive to lamivudine, a drug that inhibits HBV replication without affecting its gene expression, suggesting that HBV replication per se might not be responsible for the activation. Interestingly, the electrophoretic mobility of p-STAT3 protein bands on immunoblot was slower when AD38 cells were cultured in the absence of tetracycline, suggesting a differential phosphorylation in response to HBV expression. In HCC cells, interleukin 6 stimulates the phosphorylation of STAT3 both at serine 727 and at tyrosine 705 positions. The interleukin 6–stimulated activation of STAT3 and Akt was inhibited not only by atiprimod but also by LY294002, a phosphoinositide-3-kinase–specific inhibitor, and by NS398, a cyclooxygenase-2–selective inhibitor. The combination of these compounds did not produce any additive effect, implying that the mechanisms by which HBV activates Akt and STAT3 might also involve phosphoinositide-3-kinase and cyclooxygenase-2. Collectively, these results suggest that atiprimod could be useful as a multifunctional drug candidate for the treatment of HCC in humans. [Mol Cancer Ther 2007;6(1):112–21]
Revealing the Design Principles of High‐Performance Biological Composites Using Ab initio and Multiscale Simulations: The Example of Lobster Cuticle

In the course of evolution nature developed materials based on organic–inorganic nanocomposites with complex, hierarchical organization from A u ngstroms to millimeters tailored via molecular self-assembly. [1–3] Such materials possess outstanding stiffness, toughness, and strength related to their low density, while the mechanical characteristics of their underlying constituents are rather modest. [2,4] This remarkable performance is a consequence of their hierarchical structure, the specific design at each level of organization, and the inherent strong heterogeneity [4] resulting in the accommodation of macroscopic loadings bydifferentdeformationmechanisms at differentlength scales. Therefore, to understand the macroscopic mechanical properties of the tissue, one should take into account its structure–property relations at all length scales down to the molecular level. To date, this key challenge has been only partly addressed due to severe obstacles in obtaining mechanical and structural data at the nanometer scale. The mechanical properties of important proteins and biominerals as well as some details about their exact structure are still unknown. A powerful tool to overcome these difficulties and to better understand the structure–property relationships in biomaterials is multiscale modeling encompassing all length scales. [3,5] Some progress in the development of multiscale structure–property relationships for mineralized tissues has been achieved by combined modeling and experimental approaches applied to bone, [4] nacre, [6] and fish skin armor. [7] However, these approaches do not explicitly integrate a molecular-level description and use continuum mechanics at the meso- and macroscale (e.g., finite element analysis) coupled with experimental data obtained, for example, by nanoindentation. A
Exploring discrepancies in findings obtained with the KDD Cup '99 data set

The KDD Cup '99 data set has been widely used to evaluate intrusion detection prototypes, most based on machine learning techniques, for nearly a decade. The data set served well in the KDD Cup '99 competition to demonstrate that machine learning can be useful in intrusion detection systems. However, there are discrepancies in the findings reported in the literature. Further, some researchers have published criticisms of the data (and the DARPA data from which the KDD Cup '99 data has been derived), questioning the validity of results obtained with this data. Despite the criticisms, researchers continue to use the data due to a lack of better publicly available alternatives. Hence, it is important to identify the value of the data set and the findings from the extensive body of research based on it, which has largely been ignored by the existing critiques. This paper reports on an empirical investigation, demonstrating the impact of several methodological differences in the publicly available subsets, which uncovers several underlying causes of the discrepancy in the results reported in the literature. These findings allow us to better interpret the current body of research, and inform recommendations for future use of the data set.