Miracle-dz/UniFAR-FTUs huggingface dataset:
Protein kinase A–dependent modulation of Ca2+ sensitivity in cardiac and fast skeletal muscles after reconstitution with cardiac troponin

Protein kinase A (PKA)-dependent phosphorylation of troponin (Tn)I represents a major physiological mechanism during β-adrenergic stimulation in myocardium for the reduction of myofibrillar Ca2+ sensitivity via weakening of the interaction with TnC. By taking advantage of thin filament reconstitution, we directly investigated whether or not PKA-dependent phosphorylation of cardiac TnI (cTnI) decreases Ca2+ sensitivity in different types of muscle: cardiac (porcine ventricular) and fast skeletal (rabbit psoas) muscles. PKA enhanced phosphorylation of cTnI at Ser23/24 in skinned cardiac muscle and decreased Ca2+ sensitivity, of which the effects were confirmed after reconstitution with the cardiac Tn complex (cTn) or the hybrid Tn complex (designated as PCRF; fast skeletal TnT with cTnI and cTnC). Reconstitution of cardiac muscle with the fast skeletal Tn complex (sTn) not only increased Ca2+ sensitivity, but also abolished the Ca2+-desensitizing effect of PKA, supporting the view that the phosphorylation of cTnI, but not that of other myofibrillar proteins, such as myosin-binding protein C, primarily underlies the PKA-induced Ca2+ desensitization in cardiac muscle. Reconstitution of fast skeletal muscle with cTn decreased Ca2+ sensitivity, and PKA further decreased Ca2+ sensitivity, which was almost completely restored to the original level upon subsequent reconstitution with sTn. The essentially same result was obtained when fast skeletal muscle was reconstituted with PCRF. It is therefore suggested that the PKA-dependent phosphorylation or dephosphorylation of cTnI universally modulates Ca2+ sensitivity associated with cTnC in the striated muscle sarcomere, independent of the TnT isoform.
Mirror mirror on the ceiling: flexible wireless links for data centers

Modern data centers are massive, and support a range of distributed applications across potentially hundreds of server racks. As their utilization and bandwidth needs continue to grow, traditional methods of augmenting bandwidth have proven complex and costly in time and resources. Recent measurements show that data center traffic is often limited by congestion loss caused by short traffic bursts. Thus an attractive alternative to adding physical bandwidth is to augment wired links with wireless links in the 60 GHz band. We address two limitations with current 60 GHz wireless proposals. First, 60 GHz wireless links are limited by line-of-sight, and can be blocked by even small obstacles. Second, even beamforming links leak power, and potential interference will severely limit concurrent transmissions in dense data centers. We propose and evaluate a new wireless primitive for data centers, 3D beamforming, where 60 GHz signals bounce off data center ceilings, thus establishing indirect line-of-sight between any two racks in a data center. We build a small 3D beamforming testbed to demonstrate its ability to address both link blockage and link interference, thus improving link range and number of concurrent transmissions in the data center. In addition, we propose a simple link scheduler and use traffic simulations to show that these 3D links significantly expand wireless capacity compared to their 2D counterparts.
Predict permissive sites of protein for insertion domain

The procedure of domain insertion is proving to be an efficient way of creating modified proteins that can be used for multiple purposes. This procedure, however, requires certain calculations in order to determine permissive insertion sites of the proteins that will be modified. This paper aims to produce a scoring scheme based on the educated intuition of permissive sites to be flexible and accessible to predict the permissive sites of proteins for insertion domains.
Clutch size declines with elevation in tropical birds

ABSTRACT Clutch size commonly decreases with increasing elevation among temperate-zone and subtropical songbird species. Tropical songbirds typically lay small clutches, thus the ability to evolve even smaller clutch sizes at higher elevations is unclear and untested. We conducted a comparative phylogenetic analysis using data gathered from the literature to test whether clutch size varied with elevation among forest passerines from three tropical biogeographic regions—the Venezuelan Andes and adjacent lowlands, Malaysian Borneo, and New Guinea. We found a significant negative effect of elevation on variation in clutch size among species. We found the same pattern using field data sampled across elevational gradients in Venezuela and Malaysian Borneo. Field data were not available for New Guinea. Both sets of results demonstrate that tropical montane species across disparate biogeographic realms lay smaller clutches than closely related low-elevation species. The environmental sources of selection underlying this pattern remain uncertain and merit further investigation.
Towards effective singing voice extraction from stereophonic recordings

Extracting a singing voice from its music accompaniment can significantly facilitate certain applications of Music Information Retrieval including singer identification and singing melody extraction. In this paper, we present a hybrid approach for this purpose, which combines properties of the Azimuth Discrimination and Resynthesis (ADRess) method with Independent Component Analysis (ICA). Our proposed approach is developed specifically for the case of singing voice separation from stereophonic recordings. The paper presents the characteristics of the proposed method and details an objective evaluation of its effectiveness.
Cavin-1/PTRF alters prostate cancer cell-derived extracellular vesicle content and internalization to attenuate extracellular vesicle-mediated osteoclastogenesis and osteoblast proliferation

Background Tumour-derived extracellular vesicles (EVs) play a role in tumour progression; however, the spectrum of molecular mechanisms regulating EV secretion and cargo selection remain to be fully elucidated. We have reported that cavin-1 expression in prostate cancer PC3 cells reduced the abundance of a subset of EV proteins, concomitant with reduced xenograft tumour growth and metastasis. Methods We examined the functional outcomes and mechanisms of cavin-1 expression on PC3-derived EVs (PC3-EVs). Results PC3-EVs were internalized by osteoclast precursor RAW264.7 cells and primary human osteoblasts (hOBs) in vitro, stimulating osteoclastogenesis 37-fold and hOB proliferation 1.5-fold, respectively. Strikingly, EVs derived from cavin-1-expressing PC3 cells (cavin-1-PC3-EVs) failed to induce multinucleate osteoblasts or hOB proliferation. Cavin-1 was not detected in EVs, indicating an indirect mechanism of action. EV morphology, size and quantity were also not affected by cavin-1 expression, suggesting that cavin-1 modulated EV cargo recruitment rather than release. While cavin-1-EVs had no osteoclastogenic function, they were internalized by RAW264.7 cells but at a reduced efficiency compared to control EVs. EV surface proteins are required for internalization of PC3-EVs by RAW264.7 cells, as proteinase K treatment abolished uptake of both control and cavin-1-PC3-EVs. Removal of sialic acid modifications by neuraminidase treatment increased the amount of control PC3-EVs internalized by RAW264.7 cells, without affecting cavin-1-PC3-EVs. This suggests that cavin-1 expression altered the glycosylation modifications on PC3-EV surface. Finally, cavin-1 expression did not affect EV in vivo tissue targeting as both control and cavin-1-PC3-EVs were predominantly retained in the lung and bone 24 hours after injection into mice. Discussion Taken together, our results reveal a novel pathway for EV cargo sorting, and highlight the potential of utilizing cavin-1-mediated pathways to attenuate metastatic prostate cancer.
Cerebellar Neurons Possess a Vesicular Compartment Structurally and Functionally Similar to Glut4-Storage Vesicles from Peripheral Insulin-Sensitive Tissues

The insulin-sensitive isoform of the glucose transporting protein, Glut4, is expressed in fat as well as in skeletal and cardiac muscle and is responsible for the effect of insulin on blood glucose clearance. Recent studies have revealed that Glut4 is also expressed in the brain, although the intracellular compartmentalization and regulation of Glut4 in neurons remains unknown. Using sucrose gradient centrifugation, immunoadsorption and immunofluorescence staining, we have shown that Glut4 in the cerebellum is localized in intracellular vesicles that have the sedimentation coefficient, the buoyant density, and the protein composition similar to the insulin-responsive Glut4-storage vesicles from fat and skeletal muscle cells. In cultured cerebellar neurons, insulin stimulates glucose uptake and causes translocation of Glut4 to the cell surface. Using 18FDG (18fluoro-2-deoxyglucose) positron emission tomography, we found that physical exercise acutely increases glucose uptake in the cerebellum in vivo. Prolonged physical exercise increases expression of the Glut4 protein in the cerebellum. Our results suggest that neurons have a novel type of translocation-competent vesicular compartment which is regulated by insulin and physical exercise similar to Glut4-storage vesicles in peripheral insulin target tissues.
EXISTENCE OF SOLUTIONS FOR SOME NONLINEAR BEAM EQUATIONS *

We study the existence of solutions for some nonlinear ordinary differential equations under a nonlinear boundary condition which arise on beam theory. Assuming suitable conditions we prove the existence of at least one solution applying topological methods. 1 – Introduction This work is devoted to the study of the existence of solutions for some nonlinear ordinary differential equations under a nonlinear boundary condition. In 1995 Rebelo and Sanchez [9] have considered the second order problem
Heuristics and biases: interactions among numeracy, ability, and reflectiveness predict normative responding

In Stanovich's (2009a, 2011) dual-process theory, analytic processing occurs in the algorithmic and reflective minds. Thinking dispositions, indexes of reflective mind functioning, are believed to regulate operations at the algorithmic level, indexed by general cognitive ability. General limitations at the algorithmic level impose constraints on, and affect the adequacy of, specific strategies and abilities (e.g., numeracy). In a study of 216 undergraduates, the hypothesis that thinking dispositions and general ability moderate the relationship between numeracy (understanding of mathematical concepts and attention to numerical information) and normative responses on probabilistic heuristics and biases (HB) problems was tested. Although all three individual difference measures predicted normative responses, the numeracy-normative response association depended on thinking dispositions and general ability. Specifically, numeracy directly affected normative responding only at relatively high levels of thinking dispositions and general ability. At low levels of thinking dispositions, neither general ability nor numeric skills related to normative responses. Discussion focuses on the consistency of these findings with the hypothesis that the implementation of specific skills is constrained by limitations at both the reflective level and the algorithmic level, methodological limitations that prohibit definitive conclusions, and alternative explanations.
A Non-Linear Relationship between Controller Workload and Traffic Count

Controller workload has been a focal topic in air traffic management research because it is considered a key limiting factor to capacity increase in air traffic operations. Because workload ratings are subjective and highly prone to individual differences, some researchers have tried to replace workload with more objective metrics, such as aircraft count. A significant caveat in substituting these metrics for workload ratings, however, is that their relationships are non-linear. For example, as the number of aircraft increases linearly, the controller's perceived workload jumps from low to high at a certain traffic threshold, resulting in a stepfunction increase in workload with respect to aircraft count, suggesting that controllers perceive workload categorically. The non-linear relationship between workload and aircraft count has been validated using data collected from a recent study on the En Route Free Maneuvering concept element (Lee, Prevot, Mercer, Smith, & Palmer, 2005). The results suggest that objective metrics, such as aircraft count, may not be used interchangeably with subjective workload. In addition, any estimation on workload should not be extrapolated from a set of workload measures taken from an experiment since the extrapolated workload is likely to significantly underestimate workload.
Fractional M2-branes

We consider two generalizations of the = 6 superconformal Chern-Simons-matter theories with gauge group U(N) × U(N). The first generalization is to = 6 superconformal U(M) × U(N) theories, and the second to = 5 superconformal O(2M) × USp(2N) and O(2M+1) × USp(2N) theories. These theories are conjectured to describe M2-branes probing C4/Zk in the unitary case, and C4/k in the orthogonal/symplectic case, together with a discrete flux, which can be interpreted as |M−N| fractional M2-branes localized at the orbifold singularity. The classical theories with these gauge groups have been constructed before; in this paper we focus on some quantum aspects of these theories, and on a detailed description of their M theory and type IIA string theory duals.
Motivating Goal-Directed Behavior Through Introspective Self-Talk

Although essential for psychology, introspective self-talk has rarely been studied with respect to its effects on behavior. Nevertheless, the interrogative compared with the declarative form of introspective talk may elicit more intrinsically motivated reasons for action, resulting in goal-directed behavior. In Experiment 1, participants were more likely to solve anagrams if they prepared for the task by asking themselves whether they would work on anagrams as opposed to declaring that they would. In the next three experiments, merely writing Will I as opposed to I will as part of an ostensibly unrelated handwriting task produced better anagram-solving performance and stronger intentions to exercise, which suggests that priming the interrogative structure of self-talk is enough to motivate goal-directed behavior. This effect was found to be mediated by the intrinsic motivation for action and moderated by the salience of the word order of the primes.
Saving, Growth, and Investment: A Macroeconomic Analysis Using a Panel of Countries

This paper provides a descriptive analysis of the long- and short-run correlations among saving, investment, and growth rates for 123 countries over the period 1961-94. Three results are robust across data sets and estimation methods: i) lagges saving rates are positively related to investment rates; ii) investment rates Granger cause growth rates with a negative sign; iii) growth rates Granger-cause investment with a positive sign.
Sex differences in razorbill Alca torda parent—offspring vocal recognition

SUMMARY We investigated differences in parent—offspring vocal recognition between males and females in a natural population of razorbills Alca torda, a long-lived and highly social species of auk (Family: Alcidae). Razorbills provide biparental care to their chicks while at the nest site, after which the male is the sole caregiver for an additional period at sea. Parent—offspring recognition in razorbills is most challenging once the chick becomes mobile, leaves the nest site and goes to sea with the male parent. It is during this period when selection pressure acting on recognition behaviour is expected to be strongest. As a result, we predicted that parent—offspring recognition would be better developed in the male parent, that is, show a paternal bias. To test this prediction we used vocal playback experiments conducted on breeding razorbills at the Gannet Islands, Labrador, Canada. We found (1) most positive responses to playbacks (vocal and phonotactic) occurred close to fledging, (2) males responded more to calls from their chicks than to calls from strange chicks, (3) females responded indifferently to calls from their own or strange chicks and (4) chicks responded more to calls from their male parent than to calls from other adult males. The results provide clear evidence of mutual vocal recognition between the male parent and the chick but not between the female parent and the chick, supporting the prediction that parent—offspring recognition is male biased in this species. Such a bias could have important social implications for a variety of behavioural and basic life history traits such as cooperation and sex-biased dispersal.
Large-scale galactic turbulence: can self-gravity drive the observed H i velocity dispersions?

Observations of turbulent velocity dispersions in the HI component of galactic discs show a characteristic floor in galaxies with low star formation rates and within individual galaxies the dispersion profiles decline with radius. We carry out several high-resolution adaptive mesh simulations of gaseous discs embedded within dark matter haloes to explore the roles of cooling, star formation, feedback, shearing motions and baryon fraction in driving turbulent motions. In all simulations the disc slowly cools until gravitational and thermal instabilities give rise to a multiphase medium in which a large population of dense self-gravitating cold clouds are embedded within a warm gaseous phase that forms through shock heating. The diffuse gas is highly turbulent and is an outcome of large-scale driving of global non-axisymmetric modes as well as cloud-cloud tidal interactions and merging. At low star formation rates these processes alone can explain the observed HI velocity dispersion profiles and the characteristic value of similar to 10 km s(-1) observed within a wide range of disc galaxies. Supernovae feedback creates a significant hot gaseous phase and is an important driver of turbulence in galaxies with a star formation rate per unit area greater than or similar to 10(-3) M(circle dot) yr(-1) kpc(-2).
Conformally equivariant quantization: existence and uniqueness

On etablit l'existence et l'unicite d'un calcul symbolique et d'une quantification conformement equivariants sur une variete pseudo-riemannienne conformement plate (M, g), i.e. on met en evidence un isomorphisme canonique entre l'espace des polynomes sur T * M et celui des operateurs differentiels agissant sur les champs de densites tensorielles, vus tous les deux comme modules sur l'algebre de Lie o(p + 1,q + 1), ou p + q = dim(M). Cette quantification existe pour des valeurs generiques des poids de densites; on calcule les valeurs critiques de ces poids, pour lesquelles un tel isomorphisme n'existe eventuellement pas. Dans le cas des demi-densites, on obtient ainsi un star-produit conformement equivariant.
Enhancing the Physical and Social Self through Recreational Activity: Accounts of Individuals with Physical Disabilities

The impact of participation in recreational activities on perceptions of the physical and social selves of individuals with physical disabilities was explored. Eleven women (ages 19 to 54) and 12 men (ages 20 to 36) participated in individualized recreational programs including horseback riding, swimming, fitness, weightlifting, racquetball, bowling, tennis, fishing, walking, and tai chi. Tape-recorded interviews were conducted with these individuals following participation. Content analyses of the interview responses indicated that participation impacted four aspects of the physical self: (a) experiencing the body in new ways, (b) enhancing perceptions of physical attributes, (c) redefining physical capabilities, and (d) increasing perceived confidence to pursue new physical activities. Modifications in respondents’ perceptions of the social self were reflected in two themes: (a) expanding social interactions and experiences, and (b) initiating social activities in other contexts. The gains discussed by .
Square region-based coverage and connectivity probability model in wireless sensor networks

Sensing coverage and network connectivity are two fundamental issues in wireless sensor networks (WSNs). Due to resource constraints of sensor nodes, it may not be possible, or necessary, to provide full coverage and/or connectivity in WSNs. Under a certain coverage and connectivity requirement, the node deployment strategy becomes a challenging issue in randomly deployed networks. In this paper, we propose a square region-based coverage and connectivity probability model (SCCP), which reflects the relations among the coverage and connectivity rates, the number of sensor nodes, the sensing and communication ranges of sensor nodes, and the network size. This model can calculate the number of sensor nodes that need to be deployed for maintaining a certain coverage and/or connectivity rate. The simulation results have shown that the error-rate of node deployment is less than 5%, which is defined as the absolute difference between the number of sensor nodes obtained from the theoretical analysis and the number obtained from the simulation, divided by the number of sensor nodes obtained from the theoretical analysis. The proposed model is very useful in estimating the monitoring coverage and connectivity capacity when sensor nodes are distributed randomly and uniformly.
1 Hz FLARING IN SAX J1808.4–3658: FLOW INSTABILITIES NEAR THE PROPELLER STAGE

We present a simultaneous periodic and aperiodic timing study of the accreting millisecond X-ray pulsar SAX J1808.4-3658. We analyze five outbursts of the source and for the first time provide a full and systematic investigation of the enigmatic phenomenon of the 1 Hz flares observed during the final stages of some of the outbursts. We show that links between pulsations and 1 Hz flares might exist, and suggest that they are related with hydrodynamic disk instabilities that are triggered close to the disk–magnetosphere boundary layer when the system is entering the propeller regime.
The Influence of Technology Acceptance Model (TAM) on The Users’ Behavior of Sikesya Application in IAIN Surakarta

This study aims to evaluate the student acceptance of SIKESYA (Sharia Financial System/Sikesya) application as the users by using the framework of Technology Acceptance Model (TAM) and its development. The constructs being tested in this research are perceived usefulness, perceived ease of use, experience, social influence, attitute toward behavior, behavioral intention, facilitating condition, and user behaviors. As much as 80 students has been chosen as sample which were determined using purposive sampling method. The data gathered was then analyzed using partial least square (PLS). The result showed that experience did not influence the perceived ease of use, on the other hand perceived usefulness has a positif influence toward users attitude and behavior in using Sikesya, while the perceived ease of use did not influence the users atttitude and behavior at all, since the students would still use it as it is an application used as part of university services. The attitude and behavior did not influence the behavioral intention, whereas the social influence has a positif effect on behavioral intention, yet the behavioral intention gave positif impact to user’s behavior. On the other hand, facilitating condition has no effect toward users’ behavior. Keywords : Sharia Financial System (SIKESYA), Technology Acceptance Model (TAM), IAIN Surakarta