Miracle-dz/UniFAR-FTUs huggingface dataset:
Functional Characterization of CLPTM1L as a Lung Cancer Risk Candidate Gene in the 5p15.33 Locus

Cleft Lip and Palate Transmembrane Protein 1-Like (CLPTM1L), resides in a region of chromosome 5 for which copy number gain has been found to be the most frequent genetic event in the early stages of non-small cell lung cancer (NSCLC). This locus has been found by multiple genome wide association studies to be associated with lung cancer in both smokers and non-smokers. CLPTM1L has been identified as an overexpressed protein in human ovarian tumor cell lines that are resistant to cisplatin, which is the only insight thus far into the function of CLPTM1L. Here we find CLPTM1L expression to be increased in lung adenocarcinomas compared to matched normal lung tissues and in lung tumor cell lines by mechanisms not exclusive to copy number gain. Upon loss of CLPTM1L accumulation in lung tumor cells, cisplatin and camptothecin induced apoptosis were increased in direct proportion to the level of CLPTM1L knockdown. Bcl-xL accumulation was significantly decreased upon loss of CLPTM1L. Expression of exogenous Bcl-xL abolished sensitization to apoptotic killing with CLPTM1L knockdown. These results demonstrate that CLPTM1L, an overexpressed protein in lung tumor cells, protects from genotoxic stress induced apoptosis through regulation of Bcl-xL. Thus, this study implicates anti-apoptotic CLPTM1L function as a potential mechanism of susceptibility to lung tumorigenesis and resistance to chemotherapy.
Phase noise in LC oscillators

Analytical methods for the phase-noise analysis of LC-tuned oscillators are presented. The fundamental assumption used in the theoretical model is that an oscillator acts as a large-signal LC-tuned amplifier for purposes of noise analysis. This approach allows us to derive closed-form expressions for the close-to-carrier spectral density of the output noise, and to estimate the phase-noise performance of an oscillator from circuit parameters using hand analysis. The emphasis is on an engineering approach intended to facilitate rapid estimation of oscillator phase noise. Theoretical predictions are compared with results of circuit simulations using a nonlinear phase-noise simulator. The analytical results are in good agreement with simulations for weakly nonlinear oscillators. Complete nonlinear simulations are necessary to accurately predict phase noise in oscillators operating in a strongly nonlinear regime. To confirm the validity of the nonlinear phase-noise models implemented in the simulator, simulation results are compared with measurements of phase noise in a practical Colpitts oscillator, where we find good agreement between simulations and measurements.
Prevalence, putative mechanisms, and current management of sleep problems during chemotherapy for cancer

Sleep problems are highly prevalent in cancer patients undergoing chemotherapy. This article reviews existing evidence on etiology, associated symptoms, and management of sleep problems associated with chemotherapy treatment during cancer. It also discusses limitations and methodological issues of current research. The existing literature suggests that subjectively and objectively measured sleep problems are the highest during the chemotherapy phase of cancer treatments. A possibly involved mechanism reviewed here includes the rise in the circulating proinflammatory cytokines and the associated disruption in circadian rhythm in the development and maintenance of sleep dysregulation in cancer patients during chemotherapy. Various approaches to the management of sleep problems during chemotherapy are discussed with behavioral intervention showing promise. Exercise, including yoga, also appear to be effective and safe at least for subclinical levels of sleep problems in cancer patients. Numerous challenges are associated with conducting research on sleep in cancer patients during chemotherapy treatments and they are discussed in this review. Dedicated intervention trials, methodologically sound and sufficiently powered, are needed to test current and novel treatments of sleep problems in cancer patients receiving chemotherapy. Optimal management of sleep problems in patients with cancer receiving treatment may improve not only the well-being of patients, but also their prognosis given the emerging experimental and clinical evidence suggesting that sleep disruption might adversely impact treatment and recovery from cancer.
Plasma and dietary omega-3 fatty acids, fish intake, and heart failure risk in the Physicians' Health Study.

BACKGROUND Data on the relation of plasma and dietary omega-3 (n-3) fatty acids (FAs) with heart failure (HF) risk have been inconsistent. OBJECTIVE We evaluated the relation of n-3 FAs with HF in US male physicians. DESIGN We used nested case-control (n = 1572) and prospective cohort study designs (n = 19,097). Plasma phospholipid n-3 FAs were measured by using gas chromatography, and food-frequency questionnaires were used to assess dietary n-3 FAs and fish intake. Incident HF was ascertained via annual follow-up questionnaires and validated in a subsample. RESULTS The mean age was 58.7 y at blood collection. In a multivariable model, plasma α-linolenic acid (ALA) was associated with a lower risk of HF in a nonlinear fashion (P-quadratic trend = 0.02), and the lowest OR was observed in quintile 4 (0.66; 95% CI: 0.47, 0.94). Plasma EPA and DHA were not associated with HF, whereas plasma docosapentaenoic acid (DPA) showed a nonlinear inverse relation with HF for quintile 2 (OR: 0.55; 95% CI: 0.39, 0.79). Dietary marine n-3 FAs showed a trend toward a lower risk of HF in quintile 4 (HR: 0.81; 95% CI: 0.64, 1.02) and a nonlinear pattern across quintiles. Fish intake was associated with a lower risk of HF, with RRs of ~0.70 for all categories of fish consumption greater than one serving per month. CONCLUSIONS Our data are consistent with an inverse and nonlinear relation of plasma phospholipid ALA and DPA, but not EPA or DHA, with HF risk. Fish consumption greater than once per month was associated with a lower HF risk.
Treating delayed endoscopic sphincterotomy-induced bleeding: epinephrine injection with or without thermotherapy.

AIM To compare the hemostatic efficacy between epinephrine injection alone and epinephrine injection combined with thermotherapy for delayed post-endoscopic sphincterotomy (ES) bleeding. METHODS Cases with delayed post-ES bleeding undergoing epinephrine injection alone (epinephrine injection group, n = 26) or epinephrine combined with thermotherapy (combination therapy group, n = 33) in our institution between 1999 and 2007 were retrospectively investigated. The main outcome measurements were: initial endoscopic hemostasis, re-bleeding, complications, requirement of angiographic embolization or surgery, requirement for blood transfusion, and mortality. RESULTS The initial hemostatic efficacy was 96.2% for epinephrine injection alone and 100% for combination therapy (P = 0.44). There were four patients with re-bleeding in each group (16.0% vs 12.1%, P = 0.72). There was only one complication of pancreatitis from the combination therapy group. Three patients (11.5%) in the epinephrine injection group and one patient (3%) in the combination therapy group required angiographic embolization or surgery (P = 0.31). The total number of blood transfusions was not significantly different between the two groups (3.5 +/- 4.6 U vs 3.5 +/- 4.5 U, P = 0.94). There was no bleeding-related death in either group. CONCLUSION Epinephrine injection alone is as effective as epinephrine injection combined with thermotherapy for the management of delayed post-ES bleeding.
Heritable Endosymbionts of Drosophila

Although heritable microorganisms are increasingly recognized as widespread in insects, no systematic screens for such symbionts have been conducted in Drosophila species (the primary insect genetic models for studies of evolution, development, and innate immunity). Previous efforts screened relatively few Drosophila lineages, mainly for Wolbachia. We conducted an extensive survey of potentially heritable endosymbionts from any bacterial lineage via PCR screens of mature ovaries in 181 recently collected fly strains representing 35 species from 11 species groups. Due to our fly sampling methods, however, we are likely to have missed fly strains infected with sex ratio-distorting endosymbionts. Only Wolbachia and Spiroplasma, both widespread in insects, were confirmed as symbionts. These findings indicate that in contrast to some other insect groups, other heritable symbionts are uncommon in Drosophila species, possibly reflecting a robust innate immune response that eliminates many bacteria. A more extensive survey targeted these two symbiont types through diagnostic PCR in 1225 strains representing 225 species from 32 species groups. Of these, 19 species were infected by Wolbachia while only 3 species had Spiroplasma. Several new strains of Wolbachia and Spiroplasma were discovered, including ones divergent from any reported to date. The phylogenetic distribution of Wolbachia and Spiroplasma in Drosophila is discussed.
An Introduction to Applied Multivariate Analysis

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Evidence-Based Health Policy--Lessons from the Global Burden of Disease Study

The Global Burden of Disease Study, a comprehensive regional and global assessment of mortality and disability from 107 diseases and injuries and 10 risk factors, is an example of an evidence-based input to public health policy debate. The study, which includes projections of the burden through the year 2020, uses the disability-adjusted life year as a composite measure of years of life lost due to premature mortality and years lived with disability. Future patterns of death and disability are likely to change dramatically because of aging of the world's population, the epidemic of tobacco-related disease, the human immunodeficiency virus epidemic, and the likely reduction in death rates from communicable diseases in children.
Urbanopoly -- A Social and Location-Based Game with a Purpose to Crowdsource Your Urban Data

Checking-in various venues in our surrounding environment via location-based apps like foursquare is becoming more and more popular; this behaviour makes people share some “bits” of their location with their friends. Exploiting this trend in a Human Computation fashion to collect information about urban environments is the aim of the Urbanopoly Android app - a social, mobile and location-based Game with a Purpose designed around the idea of the “monopoly” board game. In this paper, we illustrate the main design choices for Urbanopoly - including the use of social media like Facebook in the context of a Human Computation approach - and we explain the gameplay.
Self-presentation as a function of perceived closeness and trust with romantic partners, friends, and acquaintances

ABSTRACT Self-presentation represents behaviors used in establishing an identity with others; such behaviors may differ across various interpersonal relationships. The current article presents two studies examining differences in self-presentation to acquaintances, friends, and romantic partners among college students in relationships. Study 1 was an experiment, and Study 2 utilized a within-subject design. Results showed that individuals engaged in more self-presentation in more established types of relationships. Additionally, both closeness and trust served as moderators, such that those lower in closeness/trust reported more self-presentation in more established types of relationships than in less established types of relationships. At higher levels of closeness/trust, the results were somewhat inconsistent, with Study 1 finding no differences between relationship types and Study 2 finding more self-presentation to romantic partners than to friends and acquaintances. These results are among the first to suggest that individuals engage in differing levels of self-presentation, depending on the type of relationship and the extent to which they feel close to and trust the person.
Comparison of the intubating laryngeal mask airway and laryngeal tube placement during manual in‐line stabilisation of the neck

We compared the placement of the laryngeal tube (LT) with the intubating laryngeal mask airway (ILMA) in 51 patients whose necks were stabilised by manual in‐line traction. Following induction of anaesthesia and neuromuscular blockade, the LT and ILMA were inserted consecutively in a randomised, crossover design. Using pressure‐controlled ventilation (20 cmH2O inspiratory pressure), we measured insertion attempts, time to establish positive‐pressure ventilation, tidal volume, gastric insufflation, and minimum airway pressure at which gas leaked around the cuff. Data were compared using Wilcoxon signed‐rank tests; p < 0.05 was considered significant. Insertion was found to be more difficult with the LT (successful at first attempt in 16 patients) than with the ILMA (successful at first attempt in 42 patients, p < 0.0001). Time required for insertion was longer for the LT (28 [23–35] s, median [interquartile range]) than for the ILMA (20 [15–25] s, p = 0.0009). Tidal volume was less for the LT (440 [290–670] ml) than for the ILMA (630 [440–750] ml, p = 0.013). Minimum airway pressure at which gas leak occurred and incidence of gastric insufflation were similar with two devices. In patients whose necks were stabilised with manual in‐line traction, insertion of the ILMA was easier and quicker than insertion of the LT and tidal volume was greater with the ILMA than the LT.
A 50-Gb/s differential transimpedance amplifier in 65nm CMOS technology

A 50-Gb/s differential transimpedance amplifier is realized in a standard 65nm CMOS process, which exploits asymmetric transformer peaking technique for bandwidth extension and employs a modified regulated-cascode input stage with a shunt-feedback common-source amplifier for differential signaling. Measured results demonstrate 52-dBΩ transimpedance gain, 50-GHz bandwidth for 50fF photodiode capacitance, -12.3dBm sensitivity for 10-12 BER, and 49.2-mW power dissipation from a single 1.2-V supply. To the best of authors' knowledge, this chip achieves the fastest operation speed among the recently reported gigabit CMOS transimpedance amplifiers. The chip occupies the total area of 1.2×0.8mm2 including pad.
Thermal conductivity of chirality-sorted carbon nanotube networks

The thermal properties of single-walled carbon nanotubes (SWNTs) are of significant interest, yet their dependence on SWNT chirality has been, until now, not explored experimentally. Here, we used electrical heating and infrared thermal imaging to simultaneously study thermal and electrical transport in chirality-sorted SWNT networks. We examined solution processed 90% semiconducting, 90% metallic, purified unsorted (66% semiconducting), and as-grown HiPco SWNT films. The thermal conductivities of these films range from 80 to 370 W m−1 K−1 but are not controlled by chirality, instead being dependent on the morphology (i.e., mass and junction density, quasi-alignment) of the networks. The upper range of the thermal conductivities measured is comparable to that of the best metals (Cu and Ag), but with over an order of magnitude lower mass density. This study reveals important factors controlling the thermal properties of light-weight chirality-sorted SWNT films, for potential thermal and thermoelectric appl.
Performance of integrated active fiber composites in fiber reinforced epoxy laminates

Active fiber composite (AFC) composed of lead zirconate titanate (PZT) fibers with interdigitated electrodes (IDEs) has been integrated into orthotropic glass fiber reinforced plastic (GFRP) laminates to characterize the performance of AFC as a smart material component in laminated materials. Monotonic cyclic tensile loading was performed on integrated specimens at different strain levels. The AFC output was monitored to determine the effect of applied strain level on the AFC performance. It was found that the AFC sensitivity degraded beyond strains of 0.20% and approached a minimum at 0.50% strain. The degradation in the AFC performance appears to be attributed to the dominating effect of PZT fiber fragmentation during testing, as opposed to depolarization. Acoustic emission (AE) monitoring was used to detect damage in laminates during testing and was correlated with crack evidence from microscopy observations during testing to characterize damage evolution in response to strain levels.
Antimicrobial lock solutions for the prevention of catheter-related infection in patients undergoing haemodialysis: study protocol for network meta-analysis of randomised controlled trials

Introduction Catheter-related infection (CRI) is a difficult clinical problem in renal medicine, with blood stream infections occurring in up to 40% of patients with haemodialysis (HD) catheters, conferring significant rates of morbidity and mortality. Several approaches have been assessed as a means to prevent CRI. Currently, an intervention that is the source of much discussion is the use of antimicrobial lock solutions (ALS). A number of past conventional meta-analyses have compared different ALS with heparin. However, there is no consensus recommendation regarding which type of ALS is best. The purpose of our study is to carry out a network meta-analysis comparing the efficacy of different ALS for prevention of CRI in patients with HD and ranking these ALS for practical consideration. Methods and analysis We will search six electronic databases, earlier relevant meta-analyses and reference lists of included studies for randomised controlled trials (RCTs) that compared ALS for preventing episodes of CRI in patients with HD either head-to-head or against control interventions using non-ALS. Study selection and data collection will be performed by two reviewers independently. The Cochrane Risk of Bias Tool will be used to assess the quality of included studies. The primary outcome of efficacy will be catheter-related bloodstream infection (CRBSI). We will perform a Bayesian network meta-analysis to compare the relative efficacy of different ALS by WinBUGS (V.1.4.3) and STATA (V.13.0). The quality of evidence will be assessed by GRADE. Ethics and dissemination Ethical approval is not required given that this study includes no confidential personal data and no data on interventions on patients. The results of this study will be submitted to a peer-review journal for publication. Trial registration number CRD42015027010.
Establishment of the World's First Telerobotic Remote Surgical Service: For Provision of Advanced Laparoscopic Surgery in a Rural Community

Objective:To establish a telerobotic surgical service between a teaching hospital and a rural hospital for provision of telerobotic surgery and assistance to aid rural surgeons in providing a variety of advanced laparoscopic surgery to their community patients. Summary Background Data:The above service was established between St. Joseph's Hospital in Hamilton and North Bay General Hospital 400 km north of Hamilton on February 28, 2003. The service uses an IP-VPN (15 Mbps of bandwidth) commercially available network to connect the robotic console in Hamilton with 3 arms of the Zeus-TS surgical system in North Bay. Results:To date, 21 telerobotic laparoscopic surgeries have taken place between North Bay and Hamilton, including 13 fundoplications, 3 sigmoid resections, 2 right hemicolectomies, 1 anterior resection, and 2 inguinal hernia repairs. The 2 surgeons were able to operate together using the same surgical footprint and interchange roles seamlessly when desired. There have been no serious intraoperative complications and no cases have had to be converted to open surgeries. The mean hospital stays were equivalent to mean laparoscopic LOS in the tertiary institution. Conclusions:Telerobotic remote surgery is now in routine use, providing high-quality laparoscopic surgical services to patients in a rural community and providing a superior degree of collaboration between surgeons in teaching hospitals and rural hospitals. Further refinement of the robotic and telecommunication technology should ensure its wider application in the near future.
Inhibitory Properties of Antitumor Prostaglandins against Topoisomerases

Prostaglandins (PGs) having antitumor activity such as Δ12,14-PGJ2, Δ12-PGJ2, PGA2 and PGA1 strongly inhibited topoisomerase II (topo II) from human placenta, the potential order of inhibitory activity of the PGs resembling that of the antitumor activity. PGs having no antitumor activity did not inhibit topo II. Δ12,14-PGJ2 to be a potent inhibitor showed inhibitions to some extent against topo I from wheat germ, NIH3T3 and calf thymus gland, and showed no inhibition against the enzymes from Vero, A549, HeLa and COLO 201 cells. Δ12,14-PGJ2 differentially inhibited topo I from different sources. Δ12,14-PGJ2 was a topo inhibitor of the cleavable complex-nonforming type without DNA intercalation.
LULC Classification and Topographic Correction of Landsat-7 ETM+ Imagery in the Yangjia River Watershed: the Influence of DEM Resolution

DEM-based topographic corrections on Landsat-7 ETM+ imagery from rugged terrain, as an effective processing techniques to improve the accuracy of Land Use/Land Cover (LULC) classification as well as land surface parameter retrievals with remotely sensed data, has been frequently reported in the literature. However, few studies have investigated the exact effects of DEM with different resolutions on the correction of imagery. Taking the topographic corrections on the Landsat-7 ETM+ images acquired from the rugged terrain of the Yangjiahe river basin (P.R. China) as an example, the present work systematically investigates such issues by means of two commonly used topographic correction algorithms with the support of different spatial resolution DEMs. After the pre-processing procedures, i.e. atmospheric correction and geo-registration, were applied to the ETM+ images, two topographic correction algorithms, namely SCS correction and Minnaert correction, were applied to assess the effects of different spatial resolution DEMs obtained from two sources in the removal of topographic effects and LULC classifications. The results suggested that the topographic effects were tremendously reduced with these two algorithms under the support of different spatial resolution DEMs, and the performance of the topographic correction with the 1:50,000-topographic-map DEM was similar to that achieved using SRTM DEM. Moreover, when the same topographic correction algorithm was applied the accuracy of LULC classification after topographic correction based on 1:50,000-topographic-map DEM was similar as that based on SRTM DEM, which implies that the 90 m SRTM DEM can be used as an alternative for the topographic correction of ETM+ imagery when high resolution DEM is unavailable.