Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of a formal goal setting program on recovery after athletic injury

"The present study investigates the effects of a formal goal setting program on self-confidence, satisfaction, and rehabilitation adherence in injured NCAA student-athletes. Six athletes volunteered for the study (mean age=20.7 years, 4 males and 2 females). A single-subject design was used, with each participant having 3-5 weeks of baseline data collected before starting the goal setting program. Each intervention lasted between 2-6 weeks. Both short- and long-term goals were used during the intervention, and athletes were encouraged to set challenging, specific, measurable goals. Measures of confidence and rehabilitation adherence were collected weekly. Measures of satisfaction (for both the athlete and the supervising certified athletic trainer or physical therapist) were collected post-baseline and post-intervention. Each athlete also participated in a post-intervention debriefing to evaluate the goal setting program. Results demonstrated varied effects across participants. Three participants showed increased confidence and adherence during the goal setting program. Results for satisfaction were mixed. The program evaluation revealed that all participants found the program useful and would recommend it for other injured athletes. This study acts as a preliminary study on the use of a goal-setting program in athletic injury rehabilitation programs. Study limitations are presented and directions for future research provide. "--Abstract from author supplied metadata.
Comparisons of Weight Concepts in Groups of Neurotic, Normal and Anorexic Females

Summary A group of normal women and a group of women in hospital for treatment of a neurosis but without a disorder of eating were compared with a group of anorexic patients in terms of their attitudes to weight. All subjects completed a rank order form of repertory grid. Differences in construct patterning between the anorexic patients and the other female groups could not be accounted for by social class, age or neurotic disorder. The most psychologically significant finding was a positive correlation between the constructs self at normal weight and ideal weight instead of a negative correlation which clinical experience would lead one to expect. Four explanations are proposed to account for this finding.
Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch

The membrane-bound transcription factor ATF6α plays a cytoprotective role in the unfolded protein response (UPR), required for cells to survive ER stress. Activation of ATF6α promotes cell survival in cancer models. We used cell-based screens to discover and develop Ceapins, a class of pyrazole amides, that block ATF6α signaling in response to ER stress. Ceapins sensitize cells to ER stress without impacting viability of unstressed cells. Ceapins are highly specific inhibitors of ATF6α signaling, not affecting signaling through the other branches of the UPR, or proteolytic processing of its close homolog ATF6β or SREBP (a cholesterol-regulated transcription factor), both activated by the same proteases. Ceapins are first-in-class inhibitors that can be used to explore both the mechanism of activation of ATF6α and its role in pathological settings. The discovery of Ceapins now enables pharmacological modulation all three UPR branches either singly or in combination. DOI: http://dx.doi. org/10.7554/eLife.11878. 001
Expression of P. falciparum var Genes Involves Exchange of the Histone Variant H2A.Z at the Promoter

Plasmodium falciparum employs antigenic variation to evade the human immune response by switching the expression of different variant surface antigens encoded by the var gene family. Epigenetic mechanisms including histone modifications and sub-nuclear compartmentalization contribute to transcriptional regulation in the malaria parasite, in particular to control antigenic variation. Another mechanism of epigenetic control is the exchange of canonical histones with alternative variants to generate functionally specialized chromatin domains. Here we demonstrate that the alternative histone PfH2A.Z is associated with the epigenetic regulation of var genes. In many eukaryotic organisms the histone variant H2A.Z mediates an open chromatin structure at promoters and facilitates diverse levels of regulation, including transcriptional activation. Throughout the asexual, intraerythrocytic lifecycle of P. falciparum we found that the P. falciparum ortholog of H2A.Z (PfH2A.Z) colocalizes with histone modifications that are characteristic of transcriptionally-permissive euchromatin, but not with markers of heterochromatin. Consistent with this finding, antibodies to PfH2A.Z co-precipitate the permissive modification H3K4me3. By chromatin-immunoprecipitation we show that PfH2A.Z is enriched in nucleosomes around the transcription start site (TSS) in both transcriptionally active and silent stage-specific genes. In var genes, however, PfH2A.Z is enriched at the TSS only during active transcription in ring stage parasites. Thus, in contrast to other genes, temporal var gene regulation involves histone variant exchange at promoter nucleosomes. Sir2 histone deacetylases are important for var gene silencing and their yeast ortholog antagonises H2A.Z function in subtelomeric yeast genes. In immature P. falciparum parasites lacking Sir2A or Sir2B high var transcription levels correlate with enrichment of PfH2A.Z at the TSS. As Sir2A knock out parasites mature the var genes are silenced, but PfH2A.Z remains enriched at the TSS of var genes; in contrast, PfH2A.Z is lost from the TSS of de-repressed var genes in mature Sir2B knock out parasites. This result indicates that PfH2A.Z occupancy at the active var promoter is antagonized by PfSir2A during the intraerythrocytic life cycle. We conclude that PfH2A.Z contributes to the nucleosome architecture at promoters and is regulated dynamically in active var genes.
Robust Conversion of CCG Derivations to Phrase Structure Trees

We propose an improved, bottom-up method for converting CCG derivations into PTB-style phrase structure trees. In contrast with past work (Clark and Curran, 2009), which used simple transductions on category pairs, our approach uses richer transductions attached to single categories. Our conversion preserves more sentences under round-trip conversion (51.1% vs. 39.6%) and is more robust. In particular, unlike past methods, ours does not require ad-hoc rules over non-local features, and so can be easily integrated into a parser.
Intraperitoneal chemotherapy for colorectal cancer

The peritoneal surface remains an important failure site for patients with colorectal cancer. Peritoneal metastases of colorectal cancer are at present considered equal to distant metastatic disease. Consequently, peritoneal carcinomatosis is treated with systemic chemotherapy and surgery only to palliate complications such as obstruction. Despite the development of new chemotherapeutic agents and combinations, the results remain disappointing with a limited impact on survival. Colorectal carcinoma cells are relatively resistant to chemotherapy. Intraperitoneal chemotherapy seems to be an attractive approach in the treatment of high‐risk colorectal cancer and peritoneal carcinomatosis from colorectal origin providing high local drug concentration with limited systemic side effects. Adjuvant early postoperative intraperitoneal chemotherapy is worthwhile for consideration as treatment option after resection of high‐risk colorectal cancer. In the treatment of peritoneal carcinomatosis postoperative intraperitoneal chemotherapy leads to inadequate exposure of the peritoneal surface. Only an intraoperative intraperitoneal chemotherapy performed with direct cytotoxic drugs such as MMC and cisplatin overcome this problem. The limited drug penetration in tissue implies the need for extensive cytoreductive surgery. The results of phase II studies suggest that an increased median survival can be achieved with this approach. The natural history of this disease and the heterogeneity of the patients are such that only a randomized trial design will adequately answer the question whether regional treatment of patients with peritoneal dissemination of colorectal cancer actually prolongs survival. The results of such a study are to be expected in approximately 2 years time. J. Surg. Oncol. 2002;79:46–61. © 2002 Wiley‐Liss, Inc.
The relationship between executive function and intelligence on 11- to 12-year-old children

This study investigated the structure of the executive functions and their roles in intelligence on sixty-one children aged 11- to 12-year-old. Six executive function tasks and one intelligence test were carried out in the study. The confirmatory factor analysis has shown that the executive functions could be separated into three factors: updating, inhibition and shifting. These three factors were moderately correlated with each other, but were clearly separated. The present results were in line with previous findings from adults. There were significant correlations between measures of updating, inhibition and shifting, and intelligence. However, only the correlation between updating and intelligence remained significant when the correlations among executive functions were controlled. The study gave some theoretical support to the effect of executive functions training on intelligence and self-regulated learning.
Competing in the Dark: An Efficient Algorithm for Bandit Linear Optimization

We introduce an efficient algorithm for the problem of online linear optimization in the bandit setting which achieves the optimal O∗( √ T ) regret. The setting is a natural generalization of the nonstochastic multi-armed bandit problem, and the existence of an efficient optimal algorithm has been posed as an open problem in a number of recent papers. We show how the difficulties encountered by previous approaches are overcome by the use of a self-concordant potential function. Our approach presents a novel connection between online learning and interior point methods.
In Vitro Antimicrobial and Haemolytic Studies of Bambusa arundinaceae leaves

Article history: Received on: 16/01/2013 Revised on: 06/03/2013 Accepted on: 04/04/2013 Available online: 27/04/2013 Bambusa arundinacea locally known as Bans or bamboo, a perennial fastest growing plant. This plant is medicinally much famous. The biological activities of this plant were carried out by using standard procedures. The aim of this work was to investigate the in vitro antimicrobial and haemolytic activities of Bambusa arundinaceae leaves. The GC-MS analysis revealed that the major components determined in n-hexane extract were as n-Nonane (17.14%), 2,2,3-Trimethylbutane (5.85%), Tridecane (5.42%), and 3,4,5,6-Tetramethyloctane (5.32%). The disc diffusion and modified resazurin microtitre-plate assays were used to evaluate the inhibition zones (IZ) and minimum inhibitory concentration (MIC) of B. arundinaceae leaves extracts. The plant extracts showed considerable antimicrobial activity. The heamolytic activity against human blood erythrocytes (RBCs) was studied and the % lysis of RBCs was found to be in the range of 1.03 to 4.81. The results of the present study confirmed the considerable antimicrobial and haemolytic activities of the plant Bambusa arundinaceae.
Accurate Error Bounds for the Eigenvalues of the Kernel Matrix

The eigenvalues of the kernel matrix play an important role in a number of kernel methods, in particular, in kernel principal component analysis. It is well known that the eigenvalues of the kernel matrix converge as the number of samples tends to infinity. We derive probabilistic finite sample size bounds on the approximation error of individual eigenvalues which have the important property that the bounds scale with the eigenvalue under consideration, reflecting the actual behavior of the approximation errors as predicted by asymptotic results and observed in numerical simulations. Such scaling bounds have so far only been known for tail sums of eigenvalues. Asymptotically, the bounds presented here have a slower than stochastic rate, but the number of sample points necessary to make this disadvantage noticeable is often unrealistically large. Therefore, under practical conditions, and for all but the largest few eigenvalues, the bounds presented here form a significant improvement over existing non-scaling bounds.
Who are the users of urban parks? A study with adults from Curitiba, Brazil.

BACKGROUND The aim of this study was to analyze how sociodemographic characteristics, health, characteristics of quality of life, and perceptions of places are associated with park use in Curitiba, Brazil. METHODS A cross-sectional study with face-to-face interviews was conducted with 1461 adults who lived within the area of 500 m near 8 parks. The survey included questions about gender, age, socioeconomic status, education, marital status, body mass index, perceived health, number of morbidities, perception of quality of life, physical environment, leisure opportunities, self-satisfaction, and satisfaction with the park. The use of a specific park near the residence was identified as 1 of 3 outcomes: park use versus nonuse, park use ≥ 1 time/wk, and park use ≥ 3 times/wk. Poisson regression was used to examine associations between the independent variables and each level of park use. RESULTS Overall park use (60.9%) and ≥ 1 time/wk (32.2%) and ≥ 3 times/wk use (16.8%) were associated with age and leisure opportunities. Leisure opportunities and park satisfaction were related to more frequent visits to these outdoor areas. CONCLUSIONS These results can be used in guiding interventions that improve the quality of parks and other outdoor areas and offer leisure opportunities to the community.
Adipose tissue of human omentum is a major source of dendritic cells, which lose MHC Class II and stimulatory function in Crohn's disease

Adipose tissue is reported to contain monocyte‐like pre‐adipocytes, which may mature into macrophages, contributing to local inflammation. Dendritic cells (DC) can be derived from monocytes and initiate and regulate primary immune responses. We hypothesized, therefore, that adipose tissue may provide DC involved in local immune activity. To test this, we studied cells from human omental adipose tissue samples from 17 patients with benign gynecological disease. The hypothesis that adipose tissue DC are involved in inflammatory disease was tested by comparing these cells with those from 18 patients with Crohn's disease, where hypertrophy of adipose tissue suggests involvement in disease. A high proportion of the 1.33 ± 0.12 × 105 CD45‐positive cells/mg, obtained from control omenta, expressed CD11c, CD1a, and CD83; costimulatory molecules CD40, CD80, and CD86; and major histocompatibility complex (MHC) Class II but little CD14, CD16, or CD33. Omental cells showing morphological characteristics of DC were also observed. Metrizamide gradient‐enriched DC from these populations were potent stimulators of primary proliferation of allogeneic T cells in mixed leukocyte reactions. Increased numbers of CD45+ cells from omentum of Crohn's patients (4.50±1.08×105 CD45+ cells/mg) contained higher percentages of CD11c+ and CD40+ cells (80.8±3.8% vs. 63.4±6, P=0.032; 77.9±4% vs. 58.8±6.5, P=0.029, respectively), but MHC Class II and stimulatory capacity were almost completely lost (P=<0.001), suggesting innate activation but lost capacity to stimulate adaptive immune responses. Granulocytes were also present amongst the omental cells from Crohn's patients. Results indicated that omentum may provide DC, which could “police” local infections and contribute to and/or reflect local inflammatory activity.
Older Adults With Developmental Disabilities and Leisure: Issues, Policy, and Practice

Contents Introduction * Older Adults With Developmental Disabilities: A Brief Examination of Current Knowledge * Health, Fitness, and Quality of Life for Older Adults With Developmental Disabilities * Fitness and Exercise for Older Adults With Developmental Disabilities * Expressive Arts Programming for Older Adults Both With and Without Disabilities: An Opportunity for Inclusion * Enriching Later Life Experiences for People With Developmental Disabilities * Consumer Satisfaction for Individuals With Developmental Disabilities * Integration and Leisure Education for Older Adults With Developmental Disabilities * Issues Resolved and Unresolved: Look to the Future * Index * Reference Notes Included
Polymorphisms in the non‐coding region of the human mitochondrial genome in unrelated plateletapheresis donors

Human mitochondrial DNA polymorphisms are unique targets to discriminate nucleated cells and platelets between donor and recipient in the setting of transplantation or transfusion. We have previously used this approach to discriminate allogeneic platelets from autologous platelets after transfusion. In the present study, we used DNA sequencing to investigate polymorphisms present in two of the hypervariable segments (HVR1 and HVR2) found within the non‐coding region of the mitochondrial genome among 100 plateletapheresis donors. Alignments were made with the Cambridge Reference Sequence (CRS) for human mitochondrial DNA (mtDNA). Combining the sequencing information of HVR1 and HVR2 we could demonstrate that, of the 100 investigated mtDNA samples, none was identical to the CRS. We found a total of 2–17 polymorphisms per donor in the investigated regions, most of them were basepair substitutions (563) and insertions (151). No deletions were found. Sixty‐six of the 110 detected polymorphisms were detected in more than one sample. Seven polymorphisms are newly described and have not been published in the Mitomap database. Our results demonstrate that polymerase chain reaction analysis of the many polymorphisms found in the hypervariable region of mitochondrial DNA represents a more informative target than previously described mitochondrial polymorphisms for discriminating donor–recipient cells after transfusion or transplantation.
Knowledge, attitude and practice regarding risk of HIV infection through accidental needlestick injuries among dental students of Raichur, India

Background: Injuries from occupational accidents are associ-ated with agents of biological risk, as they are the gateway to serious and potentially lethal infectious diseases that can be spread by contact between people. Several studies have demonstrated that dental students are among the most vulnerable to blood-borne exposure. Objectives: To assess the knowledge, attitude and practice regarding risk of HIV transmission through accidental needlestick injury amongst dental students and providing supportive and proper guidelines regarding needlestick injuries and HIV infection. Study design: This was a cross-sectional study done at a dental college attached to a tertiary care hospital, which included third, fourth year students and interns. The results obtained were subjected to statistical analysis using Chi-square test. Results: Of the 120 students, 13 (11%) were not even aware that virus could be transmitted through infected needle. A significant proportion of the third year students i.e. 27 (67.5%) were not aware of correct method of disposal of disposable needles and syringes as against interns 17 (42.5%). Around 31 (26%) said that they would promote active bleeding at the site of injury and 37 (30%) said they would take post-exposure prophylaxis. Conclusion: Dental professionals are at a risk of occupational acquisition of HIV primarily due to accidental exposure to infected blood and body fluids. There is a need of correcting the existing misconceptions through education programs early in the course and providing supportive and proper guidelines regarding needlestick injuries and HIV infection.
A Low Error and High Performance Multiplexer-Based Truncated Multiplier

This paper proposes a novel adaptive pseudo-carry compensation truncation (PCT) scheme, which is derived for the multiplexer based array multiplier. The proposed method yields low average error among existing truncation methods. The new PCT based truncated array multiplier outperforms other existing truncated array multipliers by as much as 25% in terms of silicon area and delay, and consumes about 40% less dynamic power than the full-width multiplier for 32-bit operation. The proposed truncation scheme is applied to an image compression algorithm. Due to its low truncation error, the mean square errors (MSE) of various reconstructed images are found to be comparable to those obtained with full-precision multiplication.
Effect of topical cyclosporine rinse on oral lichen planus. A double-blind analysis.

BACKGROUND Oral lichen planus is a relatively common disorder of the mouth that can be debilitating. It is frequently palliated with topical or systemic corticosteroids and retinoids. These treatments require prolonged use, however, and are not always effective. METHODS In a double-blind trial, 16 patients with symptomatic oral lichen planus were randomly assigned to receive either topical cyclosporine or its vehicle. The patients swished and expectorated 5 ml of medication (containing 100 mg of cyclosporine per milliliter) three times daily. RESULTS After eight weeks, the eight recipients of cyclosporine had marked improvement in erythema (P = 0.003), erosion (P = 0.02), reticulation (presence of white lacelike lesions; P = 0.007), and pain (P = 0.002), whereas the eight recipients of vehicle had no change or minimal improvement. After a switch to cyclosporine for eight weeks, the vehicle-treated patients had improvement similar to that seen in the patients who initially received cyclosporine. There were no systemic side effects. In most cases blood cyclosporine levels were low or undertectable. Cyclosporine levels present in specimens of oral mucosa at the end of therapy four hours after the patients swished were similar to the levels previously reported in psoriatic lesions after treatment with systemic cyclosporine (14 mg per kilogram of body weight per day). CONCLUSIONS As a topical preparation, cyclosporine may be useful in the treatment of oral lichen planus and possibly other cutaneous disorders.
Distribution of polyglutamylated tubulin in the flagellar apparatus of green flagellates.

Polyglutamylation is a widely distributed posttranslational modification of tubulin that can be demonstrated either by biochemical analysis or by the use of specific antibodies like GT335. Western blotting using GT335 demonstrated that polyglutamylated tubulin is enriched in isolated basal apparatus of Spermatozopsis similis. Single- and double-labeling experiments, using indirect immunofluorescence and immunogold electron microscopy of isolated cytoskeletons of S. similis and Chlamydomonas reinhardtii, revealed that polyglutamylated tubulin was predominately present in the basal bodies and the proximal part of the axonemes. Using immunogold labeling of whole mounts of Spermatozopsis cytoskeletons, we obtained evidence for a predominant occurrence of polyglutamylated tubulin in the B-tubule of the axonemal doublets. Polyglutamylation occurs early during premitotic basal body assembly in S. similis, whereas the probasal bodies of Chlamydomonas, which are present through interphase, showed a reduced staining with GT335 indicating that polyglutamylation is involved in basal body maturation. During flagella regeneration of C. reinhardtii, polyglutamylation preceded detyrosination and became visible shortly after the onset of flagellar regeneration. In C. reinhardtii and S. similis polyglutamylated tubulin was absent or highly reduced in the flagellar transition region, a specialized part of the flagellum linking the basal body to the axoneme. Furthermore, the transition region and the neighboring part of the axoneme showed reduced staining with L3, an antibody directed against detyrosinated tubulin. The results indicate that differences in the modification pattern can occur in a confined area of individual microtubules. The deficiency of polyglutamylated and detyrosinated tubulin in the transition region could have functional implications for flagellar turnover or excision.