Miracle-dz/UniFAR-FTUs huggingface dataset:
Diversity and population structure of red rice germplasm in Bangladesh

While the functionality and healthy food value of red rice have increased its popularity, such that market demand for it is expected to rise, most strains suffer from low grain yield. To perform diversity and population structure analyses of red rice germplasm, therefore, becomes essential for improving yields for commercial production. In this study, fifty red rice germplasm from the Bangladesh Rice Research Institute (BRRI) genebank were characterized both morphologically and genetically using fifty simple sequence repeat (SSR) markers. Overall, 162 alleles were detected by the markers with the detected allele number varying from two to seven. Additionally, 22 unique alleles were identified for use as a germplasm diagnostic tool. The highest and lowest polymorphic information content (PIC) indices were 0.75 and 0.04 found in markers RM282 and RM304, respectively, and genetic diversity was moderate, varying from 0.05 to 0.78 (average: 0.35). While phylogenetic cluster analysis of the fifteen distance-based agro-morphological traits divided the germplasm into five clusters (I, II, III, IV and V), a similar SSR analysis yielded only three major groups (I, II, and III), and a model-based population structure analysis yielded four (A, B, C and D). Both principal component and neighbors joining tree analysis from the population structure method showed the tested germplasm as highly diverse in structure. Moreover, an analysis of molecular variance (AMOVA), as well as a pairwise FST analysis, both indicated significant differentiation (ranging from 0.108 to 0.207) among all pairs of populations, suggesting that all four population structure groups differed significantly. Populations A and D were the most differentiated from each other by FST. Findings from this study suggest that the diverse germplasm and polymorphic trait-linked SSR markers of red rice are suitable for the detection of economically desirable trait loci/genes for use in future molecular breeding programs.
Inhibition of osteoblast activity by zoledronic acid

INTRODUCTION: Patients treated with nitrogen-containing bisphosphonates, such as zoledronic acid (ZA), have frequently shown oral bone exposure areas, termed osteonecrosis. In addition, these patients may also present low repair and regeneration potential, mainly after tooth extractions. These side-effects caused by bisphosphonates may be due to their inhibitory effects on oral mucosa and local bone cells. OBJECTIVE: To evaluate the effects of ZA on the mineralization capacity of cultured osteoblasts. MATERIALS AND METHODS: Human immortalized osteoblasts (SaOs-2) were grown in plain culture medium (Dulbecco's Modified Eagle Medium [DMEM] + 10% fetal bovine serum [FBS]) in wells of 24-well plates. After 48-hour incubation, the plain DMEM was replaced by a solution with ZA at 5 µM which was maintained in contact with cells for seven, 14 or 21 days. After these periods, cells were evaluated regarding alkaline phosphatase (ALP) activity and mineral nodule formation (alizarin red). Data were statistically analyzed by Mann-Whitney test, at 5% of significance level. RESULTS: ZA caused significant reduction on ALP activity and mineral nodules formation by cultured osteoblasts in all evaluated periods (p < 0.05). CONCLUSION: These data indicate that ZA causes inhibition on the osteogenic phenotype of cultured human osteoblasts, which, in turn, may reduce bone repair in patients subjected to ZA therapy.
A Long‐term Follow‐up Study on Risk Factors for Hepatocellular Carcinoma among Japanese Patients with Liver Cirrhosis

To identify virological parameters (serostatus of hepatitis B surface antigen [HBsAg] and antibodies to hepatitis C virus [anti‐HCV], HCV genotypes and HCV‐RNA titer) and other clinico‐biological and lifestyle variables that may influence or predict the development of hepatocellular carcinoma (HCC) in cirrhosis, we followed 100 cirrhotic patients without HCC, who visited Kyushu University Hospital between 1985 and 1987, until the end of 1995 (follow‐up rate: 98%; average follow‐up period: 5.3 years). After elimination of 4 patients who developed HCC or were censored within the initial 6 months, 37 (39%) out of 96 patients developed HCC during follow‐up. As compared with HBsAg(+) patients, anti‐HCV(+) HBsAg(–) patients demonstrated significantly elevated HCC risk (adjusted hazard ratio [HR]=5.85, 95% confidence interval [CI] 1.65–20.67). Genotype 1 HCV infection was not associated with increased risk compared with genotype 2 (HR = 0.64, 95% CI 0.21–1.99). For genotype 1 HCV infection, patients with HCV‐RNA levels <1 Meq/ml tended to present lower risk than patients with ≥1 Meq/ml (P= 0.03). Male sex, advanced Child's class, lower serum albumin, and higher serum aminotransferase and α‐fetoprotein were also found to be strong predictors. Overall, drinking and smoking habits were not associated with significantly elevated risk. Among virological parameters, anti‐HCV positivity and, possibly high HCV‐RNA titer, were predictive of HCC occurrence in cirrhosis in our clinical setting.
Keterkaitan Visi, Misi Dan Values Terhadap Kinerja Karyawan Perusahaan Kulit “Dwi Jaya”

Abstract - The research is aim to investigate the understanding of Employment of Skin Dwi Jaya Company on vision, mission and values as well as implication on its business valuation and kompensasi system on supporting job performance. Based on qualitative analysis, the results emphasize the importance both the understanding of Employment of Skin Dwi Jaya Company valuation and kompensasi system on supporting job performance. Keyword : vision, mission, values, job performance. Abstrak – Penelitian ini bertujuan untuk menyelidiki pemahaman kerja di perusahaan kulit “Dwi Jaya” pada visi misi dan nilai-nilai serta implikasinya pada penilaian bisnis dan sistem kompensasi, untuk mendukung kinerja. Berdasarkan analisis kualitatif hasil menekankan pentingnya kedua pemahaman kerja, penilaian dan sistem kompensasi untuk mendukung kinerja pada perusahaan kulit “Dwi Jaya”. Kata kunci : visi, misi, nilai-nilai, prestasi kerja
Diet, Serum Markers and Breast Cancer Mortality in China

This county‐based correlation study examined associations of breast cancer mortality with dietary habits and certain serum biochemical markers, utilizing data collected from an ecological survey in 65 Chinese rural counties. Univariate correlation and multivariate regression analysis showed that consumption of animal foods, including eggs, fish and meat, was positively linked to county‐wide mortality rates of breast cancer in Chinese women. No clear associations between breast cancer mortality rates and consumption of green vegetables, carrots and fruits were observed in this study. A modest inverse correlation between serum vitamin C levels and breast cancer mortality was observed, while selenium levels were positively related to the mortality rates. Positive correlations for serum ferritin and hemoglobin were found, in agreement with recent reports of an elevated cancer risk with increased body iron stores. Limitations of these ecological data preclude causal inferences, but the findings provide clues to breast cancer risk and protective factors in a low incidence area of the world.
Amazon river dolphins (Inia geoffrensis) modify biosonar output level and directivity during prey interception in the wild

ABSTRACT Toothed whales have evolved to live in extremely different habitats and yet they all rely strongly on echolocation for finding and catching prey. Such biosonar-based foraging involves distinct phases of searching for, approaching and capturing prey, where echolocating animals gradually adjust sonar output to actively shape the flow of sensory information. Measuring those outputs in absolute levels requires hydrophone arrays centred on the biosonar beam axis, but this has never been done for wild toothed whales approaching and capturing prey. Rather, field studies make the assumption that toothed whales will adjust their biosonar in the same manner to arrays as they will when approaching prey. To test this assumption, we recorded wild botos (Inia geoffrensis) as they approached and captured dead fish tethered to a hydrophone in front of a star-shaped seven-hydrophone array. We demonstrate that botos gradually decrease interclick intervals and output levels during prey approaches, using stronger adjustment magnitudes than predicted from previous boto array data. Prey interceptions are characterised by high click rates, but although botos buzz during prey capture, they do so at lower click rates than marine toothed whales, resulting in a much more gradual transition from approach phase to buzzing. We also demonstrate for the first time that wild toothed whales broaden biosonar beamwidth when closing in on prey, as is also seen in captive toothed whales and bats, thus resulting in a larger ensonified volume around the prey, probably aiding prey tracking by decreasing the risk of prey evading ensonification. Summary: Wild Amazon river dolphins increase biosonar beamwidth and decrease source level during prey approach while click rates transition into a buzz phase at the time of prey capture.
Evaluation of Hand-to-Hand Bioelectrical Impedance Analysis for Estimating Percent Body Fat in Young Adults

Purposes were to (a) to examine the validity and precision of a hand-to-hand bioelectrical impedance analyzer (HBIA) and (b) to determine the effect of an acute sub-maximal aerobic exercise bout on HBIA percent body fat (%BF) measures. Forty-one young adults (21 women; 20 men) visited the laboratory for body composition assessment on two separate occasions. During the control session, %BF was assessed by HBIA twice, before and immediately after 30 min of rest, and once by air-displacement plethysmography (ADP), using the BOD POD, which was considered the criterion method for comparison. During the exercise session, HBIA %BF measurements were determined prior-to and immediately after 30 minutes of moderate-intensity treadmill exercise. HBIA significantly underestimated %BF in the total sample (mean difference (MD) = 1.4 ± 4.3%) and, when examined by gender, in the women (MD = 2.4 ± 4.1%). The standard errors of estimate (range 4.1–4.3%) also exceeded the recommended range for accuracy (<3.5%). Following exercise, there was minimal, but statistically significant reduction in HBIA-measured %BF pre- to post-exercise for the total sample (19.6 ± 6.0 vs. 19.3 ± 6.0%; p = 0.011). HBIA underestimated %BF when compared to ADP and the individual prediction error exceeded current recommendations when assessing young adults. In addition, performing sub-maximal aerobic exercise prior to the assessment decreased the %BF estimate. When one factors the exercise-induced alterations with the currently observed tendency for HBIA to underestimate %BF, it is apparent that exercise may further reduce the accuracy of this method.
Altered Excitability and Local Connectivity of mPFC-PAG Neurons in a Mouse Model of Neuropathic Pain

The medial prefrontal cortex (mPFC) plays a major role in both sensory and affective aspects of pain. There is extensive evidence that chronic pain produces functional changes within the mPFC. However, our understanding of local circuit changes to defined subpopulations of mPFC neurons in chronic pain models remains unclear. A major subpopulation of mPFC neurons project to the periaqueductal gray (PAG), which is a key midbrain structure involved in endogenous pain suppression and facilitation. Here, we used laser scanning photostimulation of caged glutamate to map cortical circuits of retrogradely labeled cortico-PAG (CP) neurons in layer 5 (L5) of mPFC in brain slices prepared from male mice having undergone chronic constriction injury (CCI) of the sciatic nerve. Whole-cell recordings revealed a significant reduction in excitability for L5 CP neurons contralateral to CCI in the prelimbic (PL), but not infralimbic (IL), region of mPFC. Circuit mapping showed that excitatory inputs to L5 CP neurons in both PL and IL arose primarily from layer 2/3 (L2/3) and were significantly reduced in CCI mice. Glutamate stimulation of L2/3 and L5 elicited inhibitory inputs to CP neurons in both PL and IL, but only L2/3 input was significantly reduced in CP neurons of CCI mice. We also observed significant reduction in excitability and L2/3 inhibitory input to CP neurons ipsilateral to CCI. These results demonstrating region and laminar specific changes to mPFC-PAG neurons suggest that a unilateral CCI bilaterally alters cortical circuits upstream of the endogenous analgesic network, which may contribute to persistence of chronic pain. SIGNIFICANCE STATEMENT Chronic pain is a significant unresolved medical problem that is refractory to traditional analgesics and can negatively affect emotional health. The role of central circuits in mediating the persistent nature of chronic pain remains unclear. Local circuits within the medial prefrontal cortex (mPFC) process ascending pain inputs and can modulate endogenous analgesia via direct projections to the periaqueductal gray (PAG). However, the mechanisms by which chronic pain alters intracortical circuitry of mPFC-PAG neurons are unknown. Here, we report specific changes to local circuits of mPFC-PAG neurons in mice displaying chronic pain behavior after nerve injury. These findings provide evidence for a neural mechanism by which chronic pain disrupts the descending analgesic system via functional changes to cortical circuits.
The prehistory of the Arabian peninsula: Deserts, dispersals, and demography

As a geographic connection between Africa and the rest of Eurasia, the Arabian Peninsula occupies a central position in elucidating hominin evolution and dispersals. Arabia has been characterized by extreme environmental fluctuation in the Quaternary, with profound evolutionary and demographic consequences. Despite the importance of the region, Arabia remains understudied. Recent years, however, have seen major developments in environmental studies and archeology, revealing that the region contains important records that should play a significant role in future paleoanthropological narratives. 1–3 The emerging picture of Arabia suggests that numerous dispersals of hominin populations into the region occurred. Populations subsequently followed autochthonous trajectories, creating a distinctive regional archeological record. Debates continue on the respective roles of regional hominin extinctions and population continuity, with the latter suggesting adaptation to arid conditions. © 2012 Wiley Periodicals, Inc.
RESEARCH ON IMAGE TRANSLATION BETWEEN SAR AND OPTICAL IMAGERY

Compare to optical sensors, Synthetic Aperture Radar (SAR) sensors can work at all time and under all weather conditions. However, SAR images are less intuitive and more difficult to understand. To complement advantages of optical and SAR sensors, a technique of image translation is put forward. Firstly, the concept named as remote sensing image translation is presented, and a set of technology thinking for multi-source remote sensing image translation is also given. Image understanding, object transformation and representation are considered as three key steps for image translation, and some specific solutions for the three steps are proposed later. Finally, an ENVISAT-ASAR image is translated into a TM image by means of feature extraction of grey scale and texture, SVM classification algorithm, seed-fill algorithm and exemplar-based texture synthesis algorithm. The experiment results demonstrate that the translated SAR images are visually similar to related optical images, while the main spatial structure information of original image is preserved, it could fill the blank regions in the incomplete TM image. All the experiments show that the proposed techniques of image translation are rational and effective.
Federal Reserve Bank of New York Staff Reports Globalization and Inflation Dynamics: the Impact of Increased Competition

This paper presents preliminary findings and is being distributed to economists and other interested readers solely to stimulate discussion and elicit comments. The views expressed in the paper are those of the author and are not necessarily reflective of views at the Federal Reserve Bank of New York or the Federal Reserve System. Any errors or omissions are the responsibility of the author. Abstract This paper analyzes the potential effect of global market competition on inflation dynamics. It does so through the lens of the Calvo model of staggered price setting, which implies that inflation depends on expected future inflation and a measure of marginal costs. I modify the assumption of a constant elasticity of demand, standard in this model, to provide a channel through which an increase in the number of traded goods may affect the degree of strategic complementarity in price setting and hence alter the dynamic response of inflation to marginal costs. I first discuss the behavior of the variables that drive the impact of trade openness on this response, and then I evaluate whether an increase in the variety of traded goods of the magnitude observed in the United States in the 1990s might have a significant quantitative impact. I find that it is difficult to argue that such an increase in trade would have generated a sufficiently large increase in U.S. market competition to reduce the slope of the inflation-marginal cost relation. ). The views expressed in this paper are those of the author and do not necessarily reflect the position of the Federal Reserve Bank of New York or the Federal Reserve System.
A Method for Eliciting Goals for Business Process Models based on Non-Functional Requirements Catalogues

While traditional approaches in business process modeling tend to focus on "how" the business processes are performed adopting a behavioral description in which business processes are described in terms of procedural aspects, in goal-oriented business process modeling, the proposals strive to extend traditional business process methodologies by providing a dimension of intentionality to business processes. One of the key difficulties in enabling one to model goal-oriented processes concerns the identification or elicitation of goals. This paper reports on a case study conducted in a Brazilian hospital, which obtained several goal models represented in i*/Tropos, each of which correspond to a business process also modeled in the scope of the study. NFR catalogues were helpful in goal elicitation, uncovering goals that did not come up during previous interviews prior to these catalogues' use.
On living as Zoe: The story of being foreign in so many ways

abstract In this short interview Jesse McGleughlin interviews activist Zoe Black. They explore notions of belonging, home and ‘foreignness’ in relation to nationality, sexual orientation and occupation. Black's experiences as “a black, migrant, woman sex worker who loves women” are explored through nuanced references to US slavery abolitionist Sojourner Truth.
Variable stoichiometry of the TatA component of the twin-arginine protein transport system observed by in vivo single-molecule imaging

The twin-arginine translocation (Tat) system transports folded proteins across the bacterial cytoplasmic membrane and the thylakoid membrane of plant chloroplasts. The essential components of the Tat pathway are the membrane proteins TatA, TatB, and TatC. TatA is thought to form the protein translocating element of the Tat system. Current models for Tat transport make predictions about the oligomeric state of TatA and whether, and how, this state changes during the transport cycle. We determined the oligomeric state of TatA directly at native levels of expression in living cells by photophysical analysis of individual yellow fluorescent protein-labeled TatA complexes. TatA forms complexes exhibiting a broad range of stoichiometries with an average of ≈25 TatA subunits per complex. Fourier analysis of the stoichiometry distribution suggests the complexes are assembled from tetramer units. Modeling the diffusion behavior of the complexes suggests that TatA protomers associate as a ring and not a bundle. Each cell contains ≈15 mobile TatA complexes and a pool of ≈100 TatA molecules in a more disperse state in the membrane. Dissipation of the protonmotive force that drives Tat transport has no affect on TatA complex stoichiometry. TatA complexes do not form in cells lacking TatBC, suggesting that TatBC controls the oligomeric state of TatA. Our data support the TatA polymerization model for the mechanism of Tat transport.
Enhancement of the Adhesive Strength between Ag Films and Mo Substrate by Ag Implanted via Ion Beam-Assisted Deposition

Silver-coated molybdenum is an optimum material selection to replace pure silver as solar cell interconnector. However, the low adhesive strength between Ag films and Mo substrate hinders the application of the interconnector, because it is difficult to form metallurgical bonding or compound in the film/substrate interface using conventional deposition. In order to improve the adhesion, some Ag particles were implanted into the surface of Mo substrate by ion beam-assisted deposition (IBAD) before the Ag films were deposited by magnetron sputtering deposition (MD). The objective of this work was to investigate the effect of different assisted ion beam energy on the film/substrate adhesive properties. In addition, the fundamental adhesion mechanism was illustrated. The results revealed that the adhesion between Ag films and Mo substrate could be greatly enhanced by IBAD. With the increase of the assisting ion beam energy, the adhesive strength first increased and then decreased, with the optimum adhesion being able to rise to 25.29 MPa when the energy of the assisting ion beam was 30 keV. It could be inferred that the combination of “intermixing layer” and “implanted layer” formed by the high-energy ion bombardment was the key to enhancing the adhesion between Ag films and Mo substrate effectively.
15. Metaphor marking and metaphor typological and functional ranges in business periodicals

This chapter analyses the distribution of marked and unmarked metaphors (Goatly, 1997) within the typological and functional ranges identified in a corpus of business periodicals (Skorczynska a Deignan, 2006). The corpus contained approximately 400,000 words and was built from journalistic articles published in The Economist, Business Week, and Fortune. The metaphors analysed functionally in a previous study (Skorczynska a Deignan, 2006), and their co-text were searched for metaphorical markers (Goatly, 1997) with a concordancer. The results obtained show that there is no significant variation with regard to metaphor marking and metaphor types identified (active and inactive). However, there are notable correlations between metaphor marking and their functions (generic, filling terminological gaps, illustrating). This confirms an earlier finding that metaphor anticipation on the text level by means of linguistic expressions does not depend on the degree of metaphor conventionalisation, but rather on the context in which a particular text is produced (Cameron a Deignan, 2003)