Miracle-dz/UniFAR-FTUs huggingface dataset:
A Single Infusion of Zoledronate Prevents Bone Loss After Stroke

Background and Purpose— Stroke is a major risk factor for hip fracture. Patients with intermediate rather than severe or mild stroke deficits at the time of hospital discharge have the most fractures. This proof-of-concept study evaluated the efficacy of a single infusion of zoledronate, an intravenous bisphosphonate, in preserving hip bone density after stroke. Methods— In a 1-year randomized, double-blind, placebo-controlled, clinical trial, 27 newly hemiplegic patients (6 females, 21 males) with acute stroke were assigned to receive 4 mg of the intravenous zoledronate (n=14) or placebo (n=13) within 35 days. Strict inclusion criteria were followed-up to ensure recruited patients were likely to have residual functional impairment. Both groups received calcium and vitamin D supplementation. The primary outcome measure was the change in bone mineral density (BMD; Lunar Prodigy) at the hemiplegic hip during the year of investigation. Results— The treatment was generally well tolerated. Mean total hip BMD was unchanged in the hemiplegic hip of the zoledronate group (mean 0.0% change), whereas in the placebo group the total hip BMD changed by −5.5%, with the greatest bone loss observed in the trochanteric subregion (mean, −8.1%). On the unaffected side the mean change in total hip BMD was +1.0% with zoledronate versus a mean change of −2.7% without. Repeated measures ANOVA confirmed the significance of the differences between groups at both hips (hemiplegic, P<0.001; unaffected, P=0.002). Conclusions— Stroke patients were protected from the deleterious effects of hemiplegia on hip bone density for at least 1 year after a single infusion of zoledronate.
Home care program for patients at high risk of hospitalization.

OBJECTIVE To assess the efficacy of a home care program designed to improve access to medical care for older adults with multiple chronic conditions who are at risk for hospitalization. STUDY DESIGN Randomized controlled trial in which participants were assigned to the home care intervention (Choices for Healthy Aging [CHA]) program or usual care. METHODS The intervention group consisted of 298 older adults at risk of hospitalization as determined by a risk stratification tool. Measures included satisfaction with medical care, medical service use, and costs of medical care. RESULTS The intervention group reported significantly greater satisfaction with care than usual care recipients (t test = 2.476; P = .014). CHA patients were less likely than usual care patients to be admitted to the hospital (25.6% and 37.1%, respectively; P = .02). There were no differences in terms of costs of care between the home care and usual care groups. CONCLUSIONS Provision of home care to older adults at high risk of hospitalization may improve satisfaction with care while reducing hospitalizations. Lack of difference in medical costs suggests that managed care organizations need to consider targeting rather than using risk stratification measures when designing programs for high-risk groups.
Gift Exchange in the Field

This study reports evidence from a field experiment that was conducted to investigate the relevance of gift exchange in a natural setting. In collaboration with a charitable organization, we sent roughly 10,000 solicitation letters to potential donors. One-third of the letters contained no gift, one-third contained a small gift, and one-third contained a large gift. Treatment assignment was random. The results confirm the economic importance of gift exchange. Compared to the no gift condition, the relative frequency of donations increased by 17 percent if a small gift was included and by 75 percent for a large gift. The study extends the current body of research on gift exchange, which is almost exclusively confined to laboratory studies. Copyright The Econometric Society 2007.
Multiple Neural Networks Malfunction in Primary Blepharospasm: An Independent Components Analysis

Primary blepharospasm (BPS) is a focal dystonia characterized by involuntary blinking and eyelid spasms. The pathophysiology of BPS remains unclear. Several neuroimaging studies have suggested dysfunction of sensory processing and sensorimotor integration, but the results have been inconsistent. This study aimed to determine whether patients with BPS exhibit altered functional brain connectivity and to explore possible correlations between these networks and clinical variables. Twenty-five patients with BPS and 25 healthy controls were enrolled. We found that the patient group exhibited decreased connectivity within the sensory-motor network (SMN), which involved regions of the bilateral primary sensorimotor cortex, supplementary motor area (SMA), right premotor cortex, bilateral precuneus and left superior parietal cortex. Within the right fronto-parietal network, decreased connections were observed in the middle frontal gyrus, dorsal lateral prefrontal cortex and inferior frontal gyrus. Regarding the salience network (SN), increased connectivity was observed in the left superior frontal gyrus and middle frontal gyrus. These findings suggest the involvement of multiple neural networks in primary BPS.
The AtrbohD-Mediated Oxidative Burst Elicited by Oligogalacturonides in Arabidopsis Is Dispensable for the Activation of Defense Responses Effective against Botrytis cinerea1[W][OA]

Oligogalacturonides (OGs) are endogenous elicitors of defense responses released after partial degradation of pectin in the plant cell wall. We have previously shown that, in Arabidopsis (Arabidopsis thaliana), OGs induce the expression of PHYTOALEXIN DEFICIENT3 (PAD3) and increase resistance to the necrotrophic fungal pathogen Botrytis cinerea independently of signaling pathways mediated by jasmonate, salicylic acid, and ethylene. Here, we illustrate that the rapid induction of the expression of a variety of genes by OGs is also independent of salicylic acid, ethylene, and jasmonate. OGs elicit a robust extracellular oxidative burst that is generated by the NADPH oxidase AtrbohD. This burst is not required for the expression of OG-responsive genes or for OG-induced resistance to B. cinerea, whereas callose accumulation requires a functional AtrbohD. OG-induced resistance to B. cinerea is also unaffected in powdery mildew resistant4, despite the fact that callose accumulation was almost abolished in this mutant. These results indicate that the OG-induced oxidative burst is not required for the activation of defense responses effective against B. cinerea, leaving open the question of the role of reactive oxygen species in elicitor-mediated defense.
Nitrergic signalling via interstitial cells of Cajal regulates motor activity in murine colon

Dysregulation of nitric oxide (NO) signalling is associated with GI motility dysfunctions like chronic constipation, achalasia or Hirschsprung's disease. The inhibitory effect of NO is mainly exerted via NO‐sensitive guanylyl cyclase (NO‐GC) which is found in different gastrointestinal (GI) cell types including smooth muscle cells (SMCs) and interstitial cells of Cajal (ICC). Here, we focus on the investigation of NO‐GC function in murine colon. Using cell‐specific knock‐out mice, we demonstrate that NO‐GC is expressed in myenteric ICC of murine colon and participates in regulation of colonic spontaneous contractions in longitudinal smooth muscle. We report a novel finding that basal enteric NO release acts via myenteric ICC to influence the generation of spontaneous contractions whereas the effects of elevated endogenous NO are mediated by SMCS in the murine proximal colon. These results help in understanding possible pathological mechanisms involved in slowed colonic action and colonic inertia.
Risk factors for HIV infection among asymptomatic pregnant women attending an antenatal clinic in western Kenya

Our objective was to evaluate HIV prevalence and identify risk factors for HIV infection among women attending the antenatal clinic (ANC) at a large public hospital in Kisumu town, western Kenya. Between June 1996 and November 1997, in the context of a study to determine the effect of placental malaria on mother-to-child transmission of HIV in western Kenya, HIV-1 antibody testing was offered to women with a singleton uncomplicated pregnancy of 32 weeks' gestation attending the ANC. Women were interviewed using a structured questionnaire and had a fingerstick blood sample collected for haemoglobin (Hb), malaria smears, and HIV antibody testing. Overall HIV seroprevalence was 26.1% (743/2844) (95% confidence interval (CI): 24.5-27.7) and in bivariate evaluation was significantly associated with anaemia (Hb< 11 g/dl) (risk ratio (RR) 1.8), malarial parasitaemia (RR 1.6), fever (axillary temperature 37.5 C at screening) (RR 1.6), a history of being treated for either vaginal discharge (RR 1.5) or tuberculosis (RR 1.6), reported alcohol consumption (RR 1.6), being an unmarried multigravida (RR 2.2) or a history of the most recent child having died (RR 2.0). Poisson regression analysis for all women identified 5 significant factors independently associated with HIV seropositivity: anaemia (adjusted RR 1.7; 95% CI 1.3-2.0), malarial parasitaemia (adjusted RR 1.7; 95% CI 1.4-2.0), a history of being treated for vaginal discharge (adjusted RR 1.5; 95% CI 1.1-2.0), fever (adjusted RR 2.0; 95% CI 1.3-3.2) and reported alcohol consumption (adjusted RR 1.6; 95% CI 1.1-2.5). Multigravidae women whose most recent child had died were also more likely to be HIV seropositive (adjusted RR 1.9; 95% CI 1.7- 2.8). Only 5.5% (156/2844) of the women had none of these risk factors, of whom 12% (18/156) were HIV(+). Even though the model containing the 5 identified factors fitted the data well (goodness-of-fit xi2=18.41, P =0.10), its collective capacity to predict HIV infection was poor; while 74% of the truly positive women were correctly predicted positive by the model, 52% of the truly negative women were misclassified. Among pregnant women attending the ANC in western Kenya, we were unable to identify a subgroup at risk of HIV infection using non-serological information, indicating that wherever possible universal access to voluntary HIV counselling and testing would be preferable to targeted screening.
The Experience of Young People Remanded in Custody: A Case for Bail Support and Supervision Schemes

This article is based on a wider PhD study examining the issue of coping on remand. The research used court observation and semi-structured interviews conducted with young prisoners aged 16 to 21 years in remand custody. The findings indicate that young people often end up in remand custody as a result of noncompliance with bail. Arising from the research, the case is made that the operation of bail support and supervision schemes may benefit these young people greatly.
Can Muscle Soreness After Intensive Work-related Activities Be Predicted?

ObjectivesIt is currently unknown whether specific determinants are predictive for developing delayed onset muscle soreness (DOMS) after heavy work-related activities. The aim of this study was to analyze whether personal characteristics and performance measures are predictive for onset, intensity, and duration of DOMS after performing work-related activities during a Functional Capacity Evaluation in healthy participants. MethodsIncluded in this study were 197 healthy participants (102 men, 95 women), all working within a broad range of professions. Five groups of predictors were tested in a multiple regression analysis model: personal variables, self-reported activity, self-reported health, perceived effort during the test, and objective outcomes of the test. Twenty-three independent variables were selected and tested with a backward regression analysis. ResultsThe onset of DOMS could be explained for 7% by the variables: sex and the work index of the Baecke questionnaire. Variance of intensity of DOMS could be explained for 13% by the variables: age, sex, and VO2max. Variance in duration of DOMS could be explained for 8% by the variables: sex and reported emotional role limitations. Onset, intensity, and duration of DOMS remain unpredictable for 87% or more. ConclusionsThe results demonstrate that the intensity and duration of self-reported DOMS can only minimally be predicted from the candidate predictors used in this study.
Justifications for bullying among Japanese schoolchildren

The present research investigated the justifications for bullying as a function of the various roles that children assume in bullying. Contrary to expectations, most children judged bullying to be right or at least permitted regardless of their role in the episode. However, children with different types of involvement in bullying showed different justification strategies. In particular, bullies were more likely to blame the victims than were children assuming other roles. Gender differences were found in the justifications provided. Boys were more likely to blame the victims, whereas girls were more likely to engage in denial of injury. These results support the notion that justifications for bullying function to sustain bullying.
Family-Friendly Environments and U.S. Army Soldier Performance and Work Outcomes

This study examined how perceptions of a family-friendly environment relate to physical fitness, efficacy beliefs, and intentions to remain in the military. Survey data and actual performance measures from 230 U.S. Army soldiers were examined. Findings indicated that a perceived family-friendly environment was positively related to intentions to remain in the military upon fulfillment of obligation. Additionally, perceptions of family-friendly environments were positively related to collective efficacy perceptions. These findings provide strong support for the need to create and maintain a strong family-friendly work environment, not only to improve the well-being of employees but also to benefit the organization's retention efforts, obtained from employees being more willing to remain with the organization.
The Terminal A Domain of the Fibrillar Accumulation-Associated Protein (Aap) of Staphylococcus epidermidis Mediates Adhesion to Human Corneocytes

ABSTRACT The opportunistic pathogen Staphylococcus epidermidis colonizes indwelling medical devices by biofilm formation but is primarily a skin resident. In many S. epidermidis strains biofilm formation is mediated by a cell wall-anchored protein, the accumulation-associated protein (Aap). Here, we investigate the role of Aap in skin adhesion. Aap is an LPXTG protein with a domain architecture including a terminal A domain and a B-repeat region. S. epidermidis NCTC 11047 expresses Aap as localized, lateral tufts of fibrils on one subpopulation of cells (Fib+), whereas a second subpopulation does not express these fibrils of Aap (Fib−). Flow cytometry showed that 72% of NCTC 11047 cells expressed Aap and that 28% of cells did not. Aap is involved in the adhesion of Fib+ cells to squamous epithelial cells from the hand (corneocytes), as the recombinant A-domain protein partially blocked binding to corneocytes. To confirm the role of the Aap A domain in corneocyte attachment, Aap was expressed on the surface of Lactococcus lactis MG1363 as sparsely distributed, peritrichous fibrils. The expression of Aap increased corneocyte adhesion 20-fold compared to L. lactis carrying Aap without an A domain. S. epidermidis isolates from catheters, artificial joints, skin, and the nose also used the A domain of Aap to adhere to corneocytes, emphasizing the role of Aap in skin adhesion. In addition, L. lactis expressing Aap with different numbers of B repeats revealed a positive correlation between the number of B repeats and adhesion to corneocytes, suggesting an additional function for the B region in enhancing A-domain-dependent attachment to skin. Therefore, in addition to its established role in biofilm formation, Aap can also promote adhesion to corneocytes and is likely to be an important adhesin in S. epidermidis skin colonization.
Effects of Caregiver Behavior on Habituation Rate and Self-Efficacy in Infants

A model for cognitive development and the development of self-efficacy in infancy was proposed. On the basis of learning-theoretical principles it was hypothesized that (a) an infant's rate of habituation to visual stimuli is a function of the amount of stimulation provided by its primary caregiver, and (b) the strength of an infant's exploratory behavior and its ability to analyse contingencies between its acts and their effects is a function of the responsiveness of the caregiver towards the infant. The subjects were 100 ninemonth-old infants from working-class families with their primary caregivers. The effects of two different intervention programs were examined, one program aiming at heightening the caregiver's responsiveness towards the infant, the second at enhancing the amount of stimulation provided to the infant. The programs were carried out by the caregivers for a period of three months. The proposed model was confirmed by the findings.
Meaning, Self and Motivation in Organizations

This paper claims that current work motivation theories are restricted in certain respects due to their overreliance on individualistic-hedonistic assumptions and their over-emphasis of cognitive-calculative processess. It is suggested that a self-concept based theory should be added to the existing core of theories in order to overcome their limitations. Certain assumptions about the relationships between the self-concept and behaviour are presented, followed by a series of theoretical propositions and some research suggestions. The implications of the theory for organizational commitment, collective work behaviour, transformational leadership and symbolic management are briefly discussed.
Against the Cartesian view on mind: Young children's difficulty with own false beliefs

The present study was concerned with children's ability to identify a prior expectation of their own as false belief. In Expt 1 a sharp improvement was found between 3 years and 5 years not only in the ability to identify own beliefs but also in the explanation of what caused that belief and in the ability to infer another person's belief from exposure to misleading information. Experiment 2 ruled out that 3-year-olds' failure with belief identification was due to a memory problem or to a misunderstanding of the test question. Experiment 3 excluded the further possibility that 3-year-olds simply failed belief identification because of embarrassment about having said something false. The younger children's difficulty with the identification of own beliefs contradicts Wimmer, Hogrefe & Sodian's (1988) proposal that young children's difficulty in understanding another person's false belief is solely due to a failure to understand informational origins of beliefs. The present finding also speaks against the Cartesian assumption that the mind is transparent to itself, an assumption which underlies the perspective taking tradition.
Employees' perceptions of organizational restructuring: The role of social support

Organizational change and restructuring is often perceived as leading to increased occupational stress, impacting negatively on the psychological well-being of employees. This pragmatic study investigates the role of social support and dispositional affect as moderators of role stress post-restructuring for employees in a public utility company. A total of 176 employees, including 37 managers, 60 graded staff and 78 industrial staff completed a self-report questionnaire, approximately 1 year postrestructuring, retrospectively assessing role conflict, ambiguity, overload and positive and negative feedback pre- and post-restructuring. Results suggested that overall role stress increased for managers/ senior officers and graded staff, but not for industrial staff. Social support was linked with lower role stress, more positive feedback and less negative feedback at post-restructuring. For certain role stressors this impact was moderated by dispositional affect, but the effect was not consistent across occupational groups. Positive affect enhanced the effect of manager support in reducing role conflict for graded staff, and the effect of co-worker support in increasing positive feedback and reducing negative feedback for industrial staff. Findings suggest that managers should pay particular attention to support and feedback for employees during periods of chronic occupational stress following organizational restructuring.
Cryoloop vitrification of rabbit oocytes.

BACKGROUND Vitrification is assumed to be a promising method to cryopreserve human oocytes but still needs optimization. In this study, rabbit oocytes (fertilized by ICSI) were vitrified with cryoloops, and the effect of three different cryopreservation protocols on spindle configuration and embryo quality was assessed. METHODS Metaphase II rabbit oocytes were randomly assigned to one of four groups: (i) control; (ii) E40 [40% ethylene glycol (EG)]; (iii) ED20 [20% EG + 20% dimethylsulphoxide (DMSO)]; and (iv) ED20 + M (20% EG + 20% DMSO + vitrification machine). After warming, one part of each group was fertilized by ICSI to examine the fertilization and embryo cleavage ability, and the others were immunostained for tubulin and chromatin before visualization using confocal microscopy. RESULTS The survival rates after warming were 79.1, 83.1 and 82.3%, respectively. In protocols E40 and ED20, the spindles were severely injured and the embryo quality not good compared with those in the ED20 + M group. CONCLUSIONS The fastest cooling rate in combination with EG and DMSO as cryoprotectants had the fewest adverse effects on the spindle configuration of rabbit oocytes and embryo development.
Race, Religion, and the Social Integration of New Immigrant Minorities in Canada 1

The social integration of Canada's new religious minorities is determined more by their racial minority status than by their religious affiliation or degree of religiosity, according to results from Statistics Canada's 2002 Ethnic Diversity Survey. Interview questions tap life satisfaction, affective ties to Canada, and participation in the wider community. Muslims, Sikhs, Buddhists, and Hindus are slower to integrate socially, mainly because they are mostly racial minorities. Degree of religiosity affects social integration in the same ways as ethnic community attachments in general, positively for some dimensions, negatively for others, and similarly for different religious groups. Patterns are similar in Quebec and the rest of Canada; results carry implications for the debate over “reasonable accommodation” of religious minorities in Quebec, and parallel debates in other provinces and countries.