Miracle-dz/UniFAR-FTUs huggingface dataset:
Growing Old in Aging Communities

Abstract: This paper provides a descriptive analysis of the experience of population aging in rural small towns from the complementary perspectives of communities and their aging residents. We begin by noting that high proportions of elderly residents distinguish small rural towns from dispersed rural communities as well as from larger towns and cities. Then we consider the socio-economic characteristics of the rural elderly and the major features of their social world. This leads, in turn, to an examination of the recursive relationship between person and place. Voluntarism is used to exemplify the dynamic link between the aging individual and the aging community. The paper concludes with a consideration of the ways that “personal troubles” may become “public issues” in rural small towns struggling to cope with their aging populations. Abstract: Cet article constitue une analyse descriptive de l’expérience du vieillissement de la population des petites villes rurales vu de deux perspectives complémentaires, celle des communautés mêmes et celle de leurs habitants vieillissants. On constate d’emblée que les proportions élevées d’habitants âgés distinguent les petites villes rurales des communautés rurales dispersées et des grandes villes et des centres metropolitains. On examine ensuite les caractéristiques socio-économiques des habitants âgés de la campagne et les traits saillants de leur monde social, ce qui entraîne à son tour une analyse du rapport récursif entre la personne et l’endroit. Les services bénévoles servent d’exemple du rapport dynamique entre celui qui vieillit et la communauté vieillissante. Pour terminer, cet article examine les façons dont les “problèmes personnels” deviendront facilement des questions “d’intérêt public” dans les petites villes rurales qui se démènent pour se charger de leurs populations vieilllissantes.
Domain-general sequence learning deficit in specific language impairment.

OBJECTIVE Grammar-specific accounts of specific language impairment (SLI) have been challenged by recent claims that language problems are a consequence of impairments in domain-general mechanisms of learning that also play a key role in the process of language acquisition. Our studies were designed to test the generality and nature of this learning deficit by focusing on both sequential and nonsequential, and on verbal and nonverbal, domains. METHOD Twenty-nine children with SLI were compared with age-matched typically developing (TD) control children using (a) a serial reaction time task (SRT), testing the learning of motor sequences; (b) an artificial grammar learning (AGL) task, testing the extraction of regularities from auditory sequences; and (c) a weather prediction task (WP), testing probabilistic category learning in a nonsequential task. RESULTS For the 2 sequence learning tasks, a significantly smaller proportion of children showed evidence of learning in the SLI than in the TD group (χ2 tests, p < .001 for the SRT task, p < .05 for the AGL task), whereas the proportion of learners on the WP task was the same in the 2 groups. The level of learning for SLI learners was comparable with that of TD children on all tasks (with great individual variation). CONCLUSIONS Taken together, these findings suggest that domain-general processes of implicit sequence learning tend to be impaired in SLI. Further research is needed to clarify the relationship of deficits in implicit learning and language.
The Heart's Response to the Portrayal of Violence

Observations have been made on the heart-rate and adrenaline and noradrenaline release in people watching films portraying violence. Contrary to the findings in other emotional situations, the heart-rate slowed during the films suggesting overactivity of the parasympathetic nerve-supply to the heart. Adrenaline excretion in the urine was increased, a finding usually connected with sympathetic overactivity. The suggestion is made that under the conditions of these observations, both sympathetic and parasympathetic overactivity are stimulated, the parasympathetic effect dominating the heart-rate.
STRESS MANAGEMENT AND OCCUPATIONAL PERFORMANCE AMONG NNABUIFE, Ezimma

This paper examines improving performance among female by Karasek’s demand control theory of job stress, the research sought to identify the effect of job stress on Universities. Data were collected using hundred and thirty five (135) respondents selected from universities in Nigeria. Data obtained were analyzed using at 0.05 level of significance. the health of female lecturers the intellectual output of female lecturers will continue to dwindle as a direct result of the absence of recommended that there should be the introduction of effective stress management policies which should be funded and monitored frequently ensuring that the objectives are achieve
Reemergence of Anopheles funestus as a vector of Plasmodium falciparum in western Kenya after long-term implementation of insecticide-treated bed nets.

Historically, the malaria vectors in western Kenya have been Anopheles funestus, Anopheles gambiae s.s. , and Anopheles arabiensis. Of these species, An. funestus populations declined the most after the introduction of insecticide-treated bed nets (ITNs) in the 1990s in Asembo, and collections of An. funestus in the region remained low until at least 2008. Contrary to findings during the early years of ITN use in Asembo, the majority of the Anopheles collected here in 2010 and 2011 were An. funestus. Female An. funestus had characteristically high Plasmodium falciparum sporozoite rates and showed nearly 100% anthropophily. Female An. funestus were found more often indoors than outdoors and had relatively low mortality rates during insecticide bioassays. Together, these results are of serious concern for public health in the region, indicating that An. funestus may once again be contributing significantly to the transmission of malaria in this region despite the widespread use of ITNs/long-lasting insecticidal nets (LLINs).
Characterization of a new Neisseria meningitidis serogroup C clone from China

This study has verified the spread of ST-7 serogroup C meningococci in China and characterized this new clone using porA typing and comparative genomic hybridization (CGH) analysis. The data would be helpful to monitor the spread of this new serogroup C meningococci sequence type clone in China and worldwide.
Relationship between foveal cone specialization and pit morphology in albinism.

PURPOSE Albinism is associated with disrupted foveal development, though intersubject variability is becoming appreciated. We sought to quantify this variability, and examine the relationship between foveal cone specialization and pit morphology in patients with a clinical diagnosis of albinism. METHODS We recruited 32 subjects with a clinical diagnosis of albinism. DNA was obtained from 25 subjects, and known albinism genes were analyzed for mutations. Relative inner and outer segment (IS and OS) lengthening (fovea-to-perifovea ratio) was determined from manually segmented spectral domain-optical coherence tomography (SD-OCT) B-scans. Foveal pit morphology was quantified for eight subjects from macular SD-OCT volumes. Ten subjects underwent imaging with adaptive optics scanning light ophthalmoscopy (AOSLO), and cone density was measured. RESULTS We found mutations in 22 of 25 subjects, including five novel mutations. All subjects lacked complete excavation of inner retinal layers at the fovea, though four subjects had foveal pits with normal diameter and/or volume. Peak cone density and OS lengthening were variable and overlapped with that observed in normal controls. A fifth hyper-reflective band was observed in the outer retina on SD-OCT in the majority of the subjects with albinism. CONCLUSIONS Foveal cone specialization and pit morphology vary greatly in albinism. Normal cone packing was observed in the absence of a foveal pit, suggesting a pit is not required for packing to occur. The degree to which retinal anatomy correlates with genotype or visual function remains unclear, and future examination of larger patient groups will provide important insight on this issue.
Quality of tuberculosis care in India: a systematic review.

BACKGROUND While Indian studies have assessed care providers' knowledge and practices, there is no systematic review on the quality of tuberculosis (TB) care. METHODS We searched multiple sources to identify studies (2000-2014) on providers' knowledge and practices. We used the International Standards for TB Care to benchmark quality of care. RESULTS Of the 47 studies included, 35 were questionnaire surveys and 12 used chart abstraction. None assessed actual practice using standardised patients. Heterogeneity in the findings precluded meta-analysis. Of 22 studies evaluating provider knowledge about using sputum smears for diagnosis, 10 found that less than half of providers had correct knowledge; 3 of 4 studies assessing self-reported practices by providers found that less than a quarter reported ordering smears for patients with chest symptoms. In 11 of 14 studies that assessed treatment, less than one third of providers knew the standard regimen for drug-susceptible TB. Adherence to standards in practice was generally lower than correct knowledge of those standards. Eleven studies with both public and private providers found higher levels of appropriate knowledge/practice in the public sector. CONCLUSIONS Available evidence suggests suboptimal quality of TB care, particularly in the private sector. Improvement of quality of care should be a priority for India.
A Stochastic Bi-Level Scheduling Approach for the Participation of EV Aggregators in Competitive Electricity Markets

This paper proposes a stochastic bi-level decision-making model for an electric vehicle (EV) aggregator in a competitive environment. In this approach, the EV aggregator decides to participate in day-ahead (DA) and balancing markets, and provides energy price offers to the EV owners in order to maximize its expected profit. Moreover, from the EV owners’ viewpoint, energy procurement cost of their EVs should be minimized in an uncertain environment. In this study, the sources of uncertainty―including the EVs demand, DA and balancing prices and selling prices offered by rival aggregators―are modeled via stochastic programming. Therefore, a two-level problem is formulated here, in which the aggregator makes decisions in the upper level and the EV clients purchase energy to charge their EVs in the lower level. Then the obtained nonlinear bi-level framework is transformed into a single-level model using Karush–Kuhn–Tucker (KKT) optimality conditions. Strong duality is also applied to the problem to linearize the bilinear products. To deal with the unwilling effects of uncertain resources, a risk measurement is also applied in the proposed formulation. The performance of the proposed framework is assessed in a realistic case study and the results show that the proposed model would be effective for an EV aggregator decision-making problem in a competitive environment.
Differences in the Activation of the Mitochondrial Permeability Transition Among Brain Regions in the Rat Correlate with Selective Vulnerability

Abstract: Mitochondria from different regions of the brain were prepared, and the activation of the mitochondrial permeability transition (MPT) by calcium was investigated by monitoring the associated mitochondrial swelling. In general, the properties of the MPT in brain mitochondria were found to be qualitatively similar to those observed in liver and heart mitochondria. Thus, swelling was inhibited by adenine nucleotides (AdNs) and low pH (<7.0), whereas thiol reagents and alkalosis facilitated swelling. Cyclosporin A and its nonimmunosuppressive analogue N‐methyl‐Val‐4‐cyclosporin A (PKF 220‐384) both inhibited swelling and prevented the translocation of cyclophilin D from the matrix to the membranes of cortical mitochondria. However, the calcium sensitivity of the MPT differed in mitochondria from three brain regions (hippocampus > cortex > cerebellum) and is correlated with the susceptibility of these regions to ischemic damage. Depleting mitochondria of AdNs by treatment with pyrophosphate ions sensitized the MPT to [Ca2+] and abolished regional differences, implying regional differences in mitochondrial AdN content. This was confirmed by measurements showing significant differences in AdN content among regions (cerebellum > cortex > hippocampus). Our data add to recent evidence that the MPT may be involved in neuronal death.
Virtual Reality Environment for Body Image Modification: A Multidimensional Therapy for the Treatment of Body Image in Obesity and Related Pathologies

The aim of this article is to investigate the possibility of inducing a significant modification on body image attitudes and behavior in obesity and related pathologies using a psychological approach based on virtual reality (VR). The design used is a clinical intervention study using five bi-weekly, VR-based therapeutical sessions. The sample was composed by 57 female obese, BED, and EDNOS patients who were seeking treatment at the Weight Reduction Unit of the Istituto Auxologico Italiano, Verbania, Italy. Various body-image related psychometric tests (Body Satisfaction Scale, Body Image Avoidance Questionnaire, Figure Rating Scale, Contour Drawing Rating Scale) were submitted to the sample at baseline and after therapy. In all samples, the subjects improved their overall body satisfaction after the treatment. The improvement was always associated to a reduction in problematic eating and social behaviors. The possibility of inducing a significant change in body image and its associated behaviors using a .
Two voltage-dependent K+ conductances with complementary functions in postsynaptic integration at a central auditory synapse

The medial nucleus of the trapezoid body (MNTB) relays auditory information important for sound source localization. MNTB neurons faithfully preserve the temporal patterning of action potentials (APs) occurring in their single giant input synapse, even at high frequencies. The aim of this work was to examine the postsynaptic potassium conductances that shape the transfer of auditory information across this glutamatergic synapse. We used whole cell patch techniques to record from MNTB neurons in thin slices of rat brainstem. Two types of potassium conductance were found which had a strong influence on an MNTB neuron's postsynaptic response. A small low voltage threshold current, Id, limited the response during each EPSP to a single brief AP. Id was specifically blocked by dendrotoxin (DTX), resulting in additional APs during the tail end of the EPSP. Thus DTX degraded the temporal fidelity of synaptic transmission, since one presynaptic AP then led to several postsynaptic APs. A second conductance was a fast delayed rectifier with a high voltage activation threshold, that rapidly repolarised APs and thus facilitated high frequency AP responses. Together, these two conductances allow high frequency auditory information to be passed accurately across the MNTB relay synapse and separately, such conductances may perform analogous functions elsewhere in the nervous system.
Pupils' Experience of Being Motivated to Learn in School: An Empirical Phenomenological Study.

The purpose of this study is to explore and describe the essence of pupils' experiences of motivation in school. The empirical material has been gathered in Sweden through self-reports and focus groups and analysed by means of an empirical phenomenological method. The research results show that two constituents--interest and progress--are necessary and sufficient for the experience of being motivated to learn in school. Interest and progress have been delineated as most invariant constituents of the investigated experience. Different factors are connected to these two essentials of experienced motivation. The most central of them is the teacher, whose approach has varied importance for the pupils' motivational experience in schoo
Pharmacokinetics of ampicillin in cirrhosis

Ampicillin pharmacokinetics was studied in 9 cirrhotic patients and in 8 healthy subjects to assess liver disease‐related differences in distribution, elimination, and bioavailability of ampicillin. Plasma, urine, and ascites fluid samples were analyzed microbiologically. After intravenous doses, the cirrhotic patients have lower initial plasma concentrations of ampicillin because of the larger volume of distribution. Such patients usually have diminished renal function, which, because renal tubular secretion is the main route of excretion of ampicillin, causes prolonged retention of ampicillin. Metabolic‐biliary clearance of ampicillin, normally accounting for removal of only 10% of the dose in normal subjects, is three times as great in cirrhotic patients. Peak ascites fluid concentrations of ampicillin ranged from 2 to 7 mcg/ml after 600 mg iv doses, and very slow clearance of ampicillin from the peritoneal cavity results in persistence in this compartment. Though absorption of ampicillin from capsules was often erratic, its bioavailability was similar in normal and cirrhotic subjects. These findings suggest that the usual course of ampicillin therapy of infections should not be altered in cirrhotic patients. On the other hand, reduction in dosage may be called for when there is renal impairment.
An evolutionary and life history perspective on human male reproductive senescence

Unlike menopause, male reproductive senescence does not involve an acute drop in fertility. Men do, however, manifest distinct changes in somatic and gonadal function with age. Moreover, population variation in male reproductive senescence reveals phenotypic plasticity resulting from environmental, lifestyle, and genetic factors. An evolutionary and life history perspective is vital for understanding male reproductive senescence because aging involves biological constraint as well as adjustments to reproductive strategies and the allocation of somatic resources. An awareness of life history–related tradeoffs between energetic and time constraints is especially useful because biological aspects of male senescence are products of environmental challenges and natural selection. This article reviews the adaptive significance of the evolutionary biology of human male senescence with particular attention to population variation. An evolutionary perspective cannot only shed light on the origins and biology of human male senescence but also provide insights into contemporary issues of male aging and health.
The Rac activator Tiam1 controls tight junction biogenesis in keratinocytes through binding to and activation of the Par polarity complex

The GTPases Rac and Cdc42 play a pivotal role in the establishment of cell polarity by stimulating biogenesis of tight junctions (TJs). In this study, we show that the Rac-specific guanine nucleotide exchange factor Tiam1 (T-lymphoma invasion and metastasis) controls the cell polarity of epidermal keratinocytes. Similar to wild-type (WT) keratinocytes, Tiam1-deficient cells establish primordial E-cadherin–based adhesions, but subsequent junction maturation and membrane sealing are severely impaired. Tiam1 and V12Rac1 can rescue the TJ maturation defect in Tiam1-deficient cells, indicating that this defect is the result of impaired Tiam1–Rac signaling. Tiam1 interacts with Par3 and aPKCζ, which are two components of the conserved Par3–Par6–aPKC polarity complex, and triggers biogenesis of the TJ through the activation of Rac and aPKCζ, which is independent of Cdc42. Rac is activated upon the formation of primordial adhesions (PAs) in WT but not in Tiam1-deficient cells. Our data indicate that Tiam1-mediated activation of Rac in PAs controls TJ biogenesis and polarity in epithelial cells by association with and activation of the Par3–Par6–aPKC polarity complex.
Nurr1 Is Required for Maintenance of Maturing and Adult Midbrain Dopamine Neurons

Transcription factors involved in the specification and differentiation of neurons often continue to be expressed in the adult brain, but remarkably little is known about their late functions. Nurr1, one such transcription factor, is essential for early differentiation of midbrain dopamine (mDA) neurons but continues to be expressed into adulthood. In Parkinson's disease, Nurr1 expression is diminished and mutations in the Nurr1 gene have been identified in rare cases of disease; however, the significance of these observations remains unclear. Here, a mouse strain for conditional targeting of the Nurr1 gene was generated, and Nurr1 was ablated either at late stages of mDA neuron development by crossing with mice carrying Cre under control of the dopamine transporter locus or in the adult brain by transduction of adeno-associated virus Cre-encoding vectors. Nurr1 deficiency in maturing mDA neurons resulted in rapid loss of striatal DA, loss of mDA neuron markers, and neuron degeneration. In contrast, a more slowly progressing loss of striatal DA and mDA neuron markers was observed after ablation in the adult brain. As in Parkinson's disease, neurons of the substantia nigra compacta were more vulnerable than cells in the ventral tegmental area when Nurr1 was ablated at late embryogenesis. The results show that developmental pathways play key roles for the maintenance of terminally differentiated neurons and suggest that disrupted function of Nurr1 and other developmental transcription factors may contribute to neurodegenerative disease.
Two Adjacent Nucleotide-Binding Site–Leucine-Rich Repeat Class Genes Are Required to Confer Pikm-Specific Rice Blast Resistance

The rice blast resistance gene Pikm was cloned by a map-based cloning strategy. High-resolution genetic mapping and sequencing of the gene region in the Pikm-containing cultivar Tsuyuake narrowed down the candidate region to a 131-kb genomic interval. Sequence analysis predicted two adjacently arranged resistance-like genes, Pikm1-TS and Pikm2-TS, within this candidate region. These genes encoded proteins with a nucleotide-binding site (NBS) and leucine-rich repeats (LRRs) and were considered the most probable candidates for Pikm. However, genetic complementation analysis of transgenic lines individually carrying these two genes negated the possibility that either Pikm1-TS or Pikm2-TS alone was Pikm. Instead, it was revealed that transgenic lines carrying both of these genes expressed blast resistance. The results of the complementation analysis and an evaluation of the resistance specificity of the transgenic lines to blast isolates demonstrated that Pikm-specific resistance is conferred by cooperation of Pikm1-TS and Pikm2-TS. Although these two genes are not homologous with each other, they both contain all the conserved motifs necessary for an NBS–LRR class gene to function independently as a resistance gene.