Miracle-dz/UniFAR-FTUs huggingface dataset:
Depth of discussion of multicultural identities in supervision and supervisory outcomes

The present study empirically examined the relationship between perceived depth of discussion of multicultural identities in clinical supervision and supervision outcomes in 132 practicum trainees and interns from American Psychological Association-accredited doctoral programs in counseling, clinical, and combined psychology. Results indicated that ethnic minority trainees and gay, lesbian, and bisexual trainees perceived increased depth of discussion of their corresponding identities compared to White trainees and heterosexual trainees, respectively. However, women and men reported no difference in perceptions of depth of discussion regarding gender. Perceived depth of discussions of three multicultural identities (gender, race/ethnicity, and sexual orientation) was significantly and positively correlated with supervisory working alliance, multicultural intervention self-efficacy, and general counseling self-efficacy, and significantly and negatively correlated with role ambiguity and role conflict. These relationships between perceived depth of discussion and role ambiguity and working alliance-rapport remained significant for the three identities while controlling for past training experiences. The relationships between perceived depth of discussion of gender and role conflict, of race/ethnicity and working alliance client focus, and of sexual orientation and role conflict, multicultural intervention, and working alliance client focus also remained significant while controlling for past training experiences. Implications for supervisory practice, training, and research are discussed.
Zeros, Quality and Space: Trade Theory and Trade Evidence

Bilateral, product-level data exhibit a number of strong patterns that can be used to evaluate international trade theories, notably the spatial incidence of "export zeros" (correlated with distance and importer size), and of export unit values (positively related to distance). We show that leading theoretical trade models fail to explain at least some of these facts, and propose a variant of the Melitz model that can account for all the facts. In our model, high quality firms are the most competitive, with heterogeneous quality increasing with firms' heterogeneous cost.
Three-Level Processing of Multiple Aggregate Continuous Queries

Aggregate Continuous Queries (ACQs) are both a very popular class of Continuous Queries (CQs) and also have a potentially high execution cost. As such, optimizing the processing of ACQs is imperative for Data Stream Management Systems (DSMSs) to reach their full potential in supporting (critical) monitoring applications. For multiple ACQs that vary in window specifications and pre-aggregation filters, existing multiple ACQs optimization schemes assume a processing model where each ACQ is computed as a final-aggregation of a sub-aggregation. In this paper, we propose a novel processing model for ACQs, called Tri Ops, with the goal of minimizing the repetition of operator execution at the sub-aggregation level. We also propose Tri Weave, a Tri Ops-aware multi-query optimizer. We analytically and experimentally demonstrate the performance gains of our proposed schemes which shows their superiority over alternative schemes. Finally, we generalize Tri Weave to incorporate the classical subsumption-based multi-query optimization techniques.
A novel mechanism of action of the fumagillin analog, TNP-470, in the B16F10 murine melanoma cell line

TNP-470, a semisynthetic derivative of fumagillin, is an acknowledged angiogenesis inhibitor, presently undergoing clinical trials. It exerts an anti-proliferative effect directed against endothelial cells. This effect is known to be based on cell cycle inhibition effected by the p53/p21 pathway. We observed short-term toxicity of TNP-470 in the B16F10 murine melanoma cell line in vitro and investigated the mechanism of action. Cell death occurred as soon as 2 h after the addition of TNP-470, without typical apoptotic features. The toxic effect could be modulated and it depended on the type of culture medium or supplementation with anti-oxidants. Addition of N-acetylcysteine protected B16F10 cells from TNP-470-induced death and inhibited an increase in the generation of reactive oxygen species (ROS), which are detected by the 2′,7′-dichlorodihydrofluorescein diacetate probe. We conclude that TNP-470 can induce intracellular generation of ROS, which act toxically inside B16F10 cells. One may suggest that this novel activity of TNP-470 might be beneficial in some cases, but it could also be responsible for some undesirable side-effects. The possibility of its modulation gives a prospect for controlling the action of this potential drug and probably its derivatives.
Adenosinergic modulation of respiratory neurones in the neonatal rat brainstem in vitro

1 The mechanism underlying adenosinergic modulation of respiration was examined in vitro by applying the whole‐cell patch‐clamp technique to different types of respiration‐related neurones located in the rostral ventrolateral medulla of neonatal rats (0‐4 days old). 2 The adenosine A1‐receptor agonist (R)‐N6‐(2‐phenylisopropyl)‐adenosine (R‐PIA, 10 μM; n= 31) increased the burst distance of rhythmic C4 inspiratory discharges and decreased the duration of inspiratory discharges (control: 8·00 ± 2·49 s and 918 ± 273 ms; R‐PIA: 12·10 ± 5·60 s and 726 ± 215 ms). 3 Expiratory neurones demonstrated a reversible decrease in input resistance (Rin), a depression of action potential discharges and a hyperpolarization of the membrane potential (Vm) during application of R‐PIA (1‐10 μM). Similar responses of Rin and Vm to R‐PIA were evident after synaptic activity had been blocked by 0·5 μM tetrodotoxin (TTX). 4 Some of the biphasic expiratory (biphasic E) neurones, but none of the inspiratory neurones, demonstrated changes in Rin or Vm during R‐PIA application. With TTX present, R‐PIA did not alter Vm or Rin in biphasic expiratory or inspiratory neurones. 5 Furthermore, R‐PIA decreased the spontaneous postsynaptic activities of all neurones examined. The effects of R‐PIA on respiratory activity, Rin and Vm could be reversed by the A1‐receptor antagonist 8‐cyclopentyl‐1, 3‐dipropylxanthine (DPCPX; 200 nM). 6 Our data suggest that the modulation of respiratory output induced by adenosinergic agents can be explained by (1) a general decrease in synaptic transmission between medullary respiration‐related neurones mediated by presynaptic A1‐receptors, and (2) an inactivation, via membrane hyperpolarization, of medullary expiratory neurones mediated by postsynaptic A1‐receptors. Furthermore, our data demonstrate that inactivation of expiratory neurones does not abolish the respiratory rhythmic activity, but only modulates respiratory rhythm in vitro.
Sleep and vigilance linked to melanism in wild barn owls

Understanding the function of variation in sleep requires studies in the natural ecological conditions in which sleep evolved. Sleep has an impact on individual performance and hence may integrate the costs and benefits of investing in processes that are sensitive to sleep, such as immunity or coping with stress. Because dark and pale melanic animals differentially regulate energy homeostasis, immunity and stress hormone levels, the amount and/or organization of sleep may covary with melanin‐based colour. We show here that wild, cross‐fostered nestling barn owls (Tyto alba) born from mothers displaying more black spots had shorter non‐REM (rapid eye movement) sleep bouts, a shorter latency until the occurrence of REM sleep after a bout of wakefulness and more wakefulness bouts. In male nestlings, the same sleep traits also correlated with their own level of spotting. Because heavily spotted male nestlings and the offspring of heavily spotted biological mothers switched sleep–wakefulness states more frequently, we propose the hypothesis that they could be also behaviourally more vigilant. Accordingly, nestlings from mothers displaying many black spots looked more often towards the nest entrance where their parents bring food and towards their sibling against whom they compete. Owlets from heavily spotted mothers might invest more in vigilance, thereby possibly increasing associated costs due to sleep fragmentation. We conclude that different strategies of the regulation of brain activity have evolved and are correlated with melanin‐based coloration.
CYCLIC FLEXURAL FATIGUE RESISTANCE OF THE REVO-S ROTARY NICKEL-TITANIUM ENDODONTIC FILES

Resistance to cyclic flexural fatigue failure is an important feature of rotary nickel-titanium (NiTi) instruments. The aim of this study was to evaluate the cyclic flexural fatigue failure resistance of RevoS Shaper Universal rotary NiTi files and to compare it to two other rotary NiTi files with similar size and taper, the Hero Shaper and the ProFile. Fifteen each of Revo-S Shaper Universal, Hero Shaper, and ProFile rotary NiTi files all with the same tip diameter and taper (ISO size 25 with 0.06 taper) were assessed. The time to failure during cyclic flexural fatigue testing was recorded. The mean time to cyclic flexural fatigue failure was 96.1 + 17.3 seconds for the Revo-S Shaper Universal, 120.5 + 24.3 seconds for the Hero Shaper, and 154.6 + 14.9 seconds for the ProFile. Differences among all three groups were statistically significant (P = 0.001). The Revo-S Shaper Universal rotary NiTi files were less resistant to cyclic flexural fatigue failure than the Hero Shaper and the ProFile files with similar tip diameter and taper.
Long PCR-based amplification of the entire mitochondrial genome from single parasitic nematodes.

Mitochondrial genome sequences provide useful markers for investigating population genetic structures because of their maternal inheritance and high evolutionary rates. There is, however, a paucity of information on mitochondrial genomes for many parasitic organisms, including nematodes, which appears to relate mainly to technical limitations and (for modestly funded laboratories) the cost associated with full mitochondrial genome sequencing. In this article, we describe a simple, relatively inexpensive long-PCR approach for the amplification (using two sets of primers) of the entire mitochondrial genome from individual parasitic nematodes for subsequent sequencing, which overcomes these limitations. We employed two species of human hookworm (Ancylostoma duodenale and Necator americanus; order Strongylida) to establish the long-PCR conditions, and then extended its use to a number of other species of parasitic nematode of the class Secernentea (orders Strongylida, Ascaridida and Rhabditida). The long-PCR method for the amplification of the entire mitochondrial genome from single nematodes, coupled with direct sequencing of amplicons, provides a useful tool for the comparative analysis of genome organisation and evolution of a range of nematode groups. It also creates a platform for molecular ecological and population genetic studies.
Leviathan as a Minority Shareholder: A Study of Equity Purchases by the Brazilian National Development Bank (BNDES), 1995-2003

There is a growing literature comparing the performance of private vs. state-owned companies. Yet, there is little work examining the effects of having the government as a minority shareholder of private companies. We conduct such a study using data for 296 publicly-traded corporations in Brazil, looking at the effects of equity purchases by the National Bank for Economic and Social Development (BNDES) on firm performance between 1995 and 2003. Our fixed-effects regressions show that BNDES's purchases of equity lead to increases in return on assets and investment in fixed assets. Finally, we find that the positive effect of BNDES' equity purchases is reduced when the target firms belong to state-owned and private pyramidal groups. Therefore, our argue that having development banks owning minority stakes can have a positive effect on performance as long as they promote long-term investments and are shielded from governmental interference and potential minority shareholder expropriation.
Breaking the myths.

2. Presence of Beggars is source to other crimes: Here again it seems to be a matter of imagination. Very often groups like alcoholics, drug addicts etc are seen as beggars and therefore such notions are created. There could be incidents of pick pocket, stealing etc for the want of drugs but it is completely unjustified to club such groups with people who are into begging out of destitution and otherwise.
Genotype comparisons for meat and eating quality traits

The National Genetic Evaluation Program (NGEP), a project coordinated by the National Pork Producers Council (NPPC) with geneticists and commercial producers in America, provided good evidence for significant differences between terminal sire lines in progeny performance for production, carcase, meat and eating quality traits. The project identified “differences among sire lines for many muscle quality traits that are directly related to eating quality and consumer acceptability of pork” (National Hog Farmer, 1995, pg 19). Moreover, considerable re-ranking of sire lines for commercial profit of producers was evident when differences in meat quality traits were considered. A subset of results from this study is shown in Table 1.
Retrieval independence between parts and wholes in successive recognition tasks

Participants studied AB word pairs and completed three recognition tests. In one recognition test each A word was presented with two distractors that did not appear on the study list. In another recognition test each B word was presented with two distractors that did not appear on the study list. In a third recognition test an AB target was presented with two distractors composed of words not on the study list. Six different groups of participants each performed the recognition tests in a different order, so that all possible orders were tested. Recognition of the A, B, and AB targets for a given study pair were independent of each other when single-word recognition preceded double-word recognition. There was almost complete independence in the reverse order. Even when recognition judgements were restricted to those for which the participants were most confident, there was independence of recognition among the three tests. A pair recognition test served as an additional study trial for the individual words; however, the reverse was not the case. All of these results were predicted by a single three-parameter mathematical model derived from the hypothesis that single-word and double-word targets had independent representations in memory.
Post-traumatic stress among Swedish ambulance personnel

Objective: Emergency workers, including ambulance personnel, must cope with a variety of duty related stressors including traumatic incident exposures. Little is known about the variables that might be associated with post-traumatic stress symptom in high risk occupational groups such as ambulance personnel. This study investigated the prevalence of post-traumatic stress disorder among Swedish ambulance personnel. Methods: To estimate the prevalence of trauma related disorders, a representative group of 362 ambulance personal from the county of Västra Götaland in Sweden was surveyed through use of a Swedish version of Antonovsky’s 13-item short version of Sense of Coherence Scale, to measure reactions to traumatic events two instruments were used, Impact of Event Scale (IES-15) and the Post Traumatic Symptom Scale (PTSS-10). A total of 223 of the ambulance personnel reported that they had had experience of what they described as traumatic situations. Results: Of those who reported a traumatic situation 15.2% scored 31 or more on the IES-15 sub scale. Scores over 31 indicate a stress reaction with certain likelihood of post-traumatic disorder. On the PTSS-10 subscale 12.1% scored 5 or more, which indicates a relative strong reaction. The study indicates that lower sense of coherence predicts post-traumatic stress. Other predictors for the extent of traumatic stress were longer job experience, age, physical and psychological workload. Conclusions: The high prevalence of post-traumatic stress disorder symptoms in ambulance personnel indicates an inability to cope with stress in daily work. The strong relation between post-traumatic stress and Sense of Coherence Scale may be useful in predicting vulnerability for post-traumatic symptoms among recently employed ambulance service personnel. To prevent or reduce the upcoming of post-traumatic stress disorder symptoms it must be possible to take leave of absence, or for a longer or shorter time be transferred to non-emergency duties. This study presents a better understanding between post-traumatic stress and underlying factors among ambulance personnel.
Antiretroviral Activity of Emtricitabine, a Potent Nucleoside Reverse Transcriptase Inhibitor

Potent triple combination regimens have greatly reduced the clinical progression, opportunistic infections and mortality associated with HIV infection [1,2]. The success of combination regimens and the need for long-term adherence to treatment have led to the search for more potent, and less toxic antiretroviral agents, more patient-friendly regimens and newer drug classes. Meanwhile, nucleoside reverse transcriptase inhibitors (NRTIs) continue to be an essential component in almost all HIV regimens [3]. An optimal combination of NRTIs appears to be essential for the inhibition of viral replication and the ultimate success of a regimen. NRTIs vary greatly in potency, sideeffects, resistance profiles and dosing convenience [3]. Because the clinical utility of combination antiretroviral regimens is limited by the prevalence of undesirable side-effects, difficulty in adherence to complex dosing schedules and the emergence of viral resistance, the search for potent, safe and well-tolerated NRTIs with favourable dosing schedules remains critical.
Oscillation Criteria for a Class of First-Order Forced Differential Equations under Impulse Effects

In this paper, we study oscillatory behaviour of all solutions of first-order delay differential equations with a forced term of the form: 8 > > x(t) r(t)x (t) 0 +p(t)x (t) q(t)x (t) = f(t); t2 [t0;1)nf ngn2N; x( + ) = In x( n) ; n2 N; wheref ngn2N is the set of fixed impulse points, ;; are delay functions and r;p;q are nonnegative continuous coefficients, while f is an integrable forcing term. Some examples are given to illustrate the applicability of the new results.
Effect of fat emulsion infusion and fat feeding on muscle glycogen utilization during cycle exercise.

Elevated plasma fatty acids have been shown to spare muscle glycogen during exercise. However, on the basis of recent findings, the saturation of fatty acids may influence this response. The purpose of this study was to determine whether saturated or unsaturated fatty acids affected muscle glycogenolysis to varying degrees during cycle exercise. Five healthy men completed three 60-min cycle ergometer trials (EX) at approximately 70% maximal O2 uptake (VO2max). Triglyceride levels were elevated by a fat feeding (FF) composed of 90% saturated fatty acids (heavy whipping cream, 90 g) or by the infusion of Intralipid (IL; Clintec Nutrition; 45 ml/h of 20% IL, 9.0 g), which was 85% unsaturated. A control trial (CON) consisted of a light breakfast (43 g carbohydrate and 1 g fat). Heparin (2,000 U) was administered 15 min before EX in FF and IL trials, resulting in one- and threefold increases in free fatty acid (FFA) levels in IL and FF, respectively. Pre-EX muscle glycogen did not differ. The utilization of muscle glycogen during 60 min of EX was less (P < 0.05) during the FF (60.0 +/- 5.2 mmol/kg wet wt) and IL (58.6 +/- 6.2 mmol/kg wet wt) compared with CON (81.8 +/- 7.5 mmol/kg wet wt). There was no difference between FF and IL in the amount of glycogen utilized. Serum triglyceride levels were greater (P < 0.05) at preheparin in FF (1.58 +/- 0.37 mmol/l) and IL (0.98 +/- 0.13 mmol/l) compared with CON (0.47 +/- 0.14 mmol/l). (ABSTRACT TRUNCATED AT 250 WORDS)
eIF4B stimulates eIF4A ATPase and unwinding activities by direct interaction through its 7-repeats region

ABSTRACT Eukaryotic translation initiation starts with binding of the eIF4F complex to the 5′-m7G cap of the mRNA. Recruitment of the 43S pre-initiation complex (PIC), formed by the 40S ribosomal subunit and other translation initiation factors, leads to formation of the 48S PIC that then scans the 5′-untranslated region (5′-UTR) toward the start codon. The eIF4F complex consists of eIF4E, the cap binding protein, eIF4A, a DEAD-box RNA helicase that is believed to unwind secondary structures in the 5′-UTR during scanning, and eIF4G, a scaffold protein that binds to both eIF4E and eIF4A. The ATPase and helicase activities of eIF4A are jointly stimulated by eIF4G and the translation initiation factor eIF4B. Yeast eIF4B mediates recruitment of the 43S PIC to the cap-bound eIF4F complex by interacting with the 40S subunit and possibly with eIF4A. However, a direct interaction between yeast eIF4A and eIF4B has not been demonstrated yet. Here we show that eIF4B binds to eIF4A in the presence of RNA and ADPNP, independent of the presence of eIF4G. A stretch of seven moderately conserved repeats, the r1-7 region, is responsible for complex formation, for modulation of the conformational energy landscape of eIF4A by eIF4B, and for stimulating the RNA-dependent ATPase- and ATP-dependent RNA unwinding activities of eIF4A. The isolated r1-7 region only slightly stimulates eIF4A conformational changes and activities, suggesting that communication of the repeats with other regions of eIF4B is required for full stimulation of eIF4A activity, for recruitment of the PIC to the mRNA and for translation initiation.
Stepping outside the circle: the ecological promise of shorter working hours

ABSTRACT The post-work thinkers of the twenty-first century represent a valuable if often neglected critical resource. These authors imagined a social alternative in which work would no longer be a main source of income, social rights and belonging. In their putative post-work future, modern advancements in production technologies, combined with a more equal social distribution of working time, would allow everybody to enjoy more free time and lead more autonomous, less work-centred lives. This article examines the significance of post-work thought to ecological debates, suggesting that shorter working hours could form a key component of a less commodity intensive mode of social development. The article also suggests that shorter working hours could be crucial for allowing people to develop more sustainable practices and, in the process, discover new and more sublime pleasures, of the kind that can only be experienced with a wealth of free time.