Miracle-dz/UniFAR-FTUs huggingface dataset:
Investigating the Prospective Sense of Agency: Effects of Processing Fluency, Stimulus Ambiguity, and Response Conflict

How do we know how much control we have over our environment? The sense of agency refers to the feeling that we are in control of our actions, and that, through them, we can control our external environment. Thus, agency clearly involves matching intentions, actions, and outcomes. The present studies investigated the possibility that processes of action selection, i.e., choosing what action to make, contribute to the sense of agency. Since selection of action necessarily precedes execution of action, such effects must be prospective. In contrast, most literature on sense of agency has focussed on the retrospective computation whether an outcome fits the action performed or intended. This hypothesis was tested in an ecologically rich, dynamic task based on a computer game. Across three experiments, we manipulated three different aspects of action selection processing: visual processing fluency, categorization ambiguity, and response conflict. Additionally, we measured the relative contributions of prospective, action selection-based cues, and retrospective, outcome-based cues to the sense of agency. Manipulations of action selection were orthogonally combined with discrepancy of visual feedback of action. Fluency of action selection had a small but reliable effect on the sense of agency. Additionally, as expected, sense of agency was strongly reduced when visual feedback was discrepant with the action performed. The effects of discrepant feedback were larger than the effects of action selection fluency, and sometimes suppressed them. The sense of agency is highly sensitive to disruptions of action-outcome relations. However, when motor control is successful, and action-outcome relations are as predicted, fluency or dysfluency of action selection provides an important prospective cue to the sense of agency.
Role of mother's genes and environment in postpartum depression

Most studies of human molecular genetics and social environment interactions on health have relied heavily on the classic diathesis-stress model that treats genetic variations and environments as being either “risky” or “protective. ” The biological susceptibility model posits that some individuals have greater genetic reactivity to stress, leading to worse outcomes in poor environments, but better outcomes in rich environments. Using a nontruncated measure of a chronic environmental stressor—socioeconomic status—measured by education, and two polymorphisms (5-HTTLPR and STin2 VNTR) of the serotonin transporter gene (5-HTT), we find strong evidence that some women are genetically more reactive to the environment, resulting in a crossover of risks of postpartum depression for the most reactive groups. We discuss how our approach and findings provide a framework for understanding some of the confusion in the gene-environment interaction literature on stress, 5-HTT, and depression.
REDUCED-ORDER MODELING AND DYNAMICS OF NONLINEAR ACOUSTIC WAVES IN A COMBUSTION CHAMBER

ABSTRACT For understanding the fundamental properties of unsteady motions in combustion chambers, and for applications of active feedback control, reduced-order models occupy a uniquely important position. A framework exists for transforming the representation of general behavior by a set of infinite-dimensional partial differential equations to a finite set of nonlinear second-order ordinary differential equations in time. The procedure rests on an expansion of the pressure and velocity fields in modal or basis functions, followed by spatial averaging to give the set of second-order equations in time. Nonlinear gasdynamics is accounted for explicitly, but all other contributing processes require modeling. Reduced-order models of the global behavior of the chamber dynamics, most importantly of the pressure, are obtained simply by truncating the modal expansion to the desired number of terms. Central to the procedures is a criterion for deciding how many modes must be retained to give accurate results. Addressing that problem is the principal purpose of this paper. Our analysis shows that, in the case of longitudinal modes, a first-mode instability problem requires a minimum of four modes in the modal truncation, whereas, for a second-mode instability, one needs to retain at least the first eight modes. A second important problem concerns the conditions under which a linearly stable system becomes unstable to sufficiently large disturbances. Previous work has given a partial answer, suggesting that nonlinear gasdynamics alone cannot produce pulsed or “triggered” true nonlinear instabilities, that suggestion is now theoretically established. Also, a certain form of the nonlinear energy addition by combustion processes is known to lead to stable limit cycles in a linearly stable system. A second form of nonlinear combustion dynamics with a new velocity coupling function that naturally displays a threshold character is shown here also to produce triggered limit-cycle behavior.
Micronutrient Status among Pregnant Women in Zinder, Niger and Risk Factors Associated with Deficiency

Anemia and micronutrient (MN) deficiencies in pregnant women are associated with adverse pregnancy outcomes. In Niger, 58.6% of pregnant women are anemic; however, MN statuses are unknown. The study objectives were to estimate the prevalence of MN deficiencies among pregnant women in Zinder, Niger and explore associated risk factors. Pregnant women living in randomly selected rural villages (n = 88) were included. Capillary and venous blood samples (n = 770) were analyzed for hemoglobin (Hb) and plasma ferritin, soluble transferrin receptor (sTfR), zinc (pZn), retinol binding protein (RBP), folate and vitamin B12. C-reactive protein and alpha-1-acid glycoprotein were measured to adjust for inflammation. The prevalence of MN deficiencies in pregnant woman was high, indicative of a severe public health problem. Prevalence of iron deficiency was 20.7% and 35.7%, by ferritin (<15 µg/L) and sTfR (>8.3 mg/L), respectively. In total, 40.7% of women had low pZn (<50 µg/dL), 79.7% had marginal RBP (<1.32 µmol/L), 44.3% of women had low folate (<10 nmol/L) and 34.8% had low B12 concentrations (<148 pmol/L). Common risk factors associated with MN status included gravidity, mid-upper-arm circumference, geophagy, malaria, and result of the woman’s last pregnancy. Interventions to promote the strengthening of antenatal care, and access and adherence to nutrition and health interventions are critical among pregnant women in this population.
Scaling Machine Learning and Statistics for Web Applications

Scaling web applications like recommendation systems, search and computational advertising is challenging. Such systems have to make astronomical number of decisions every day on what to serve users when they are visiting the website and/or using the mobile app. Machine learning and statistical modeling approaches that can obtain insights by continuously processing large amounts of data emitted at very high frequency by these applications have emerged as the method of choice. However, there are three challenges to scale such methods : a) scientific b) infrastructure and c) organizational. I will provide an overview of these challenges and the strategies we have adopted at LinkedIn to address those. Throughout, I will illustrate with examples from real-world applications at LinkedIn.
Dosimetry revisited for the HDR 192Ir brachytherapy source model mHDR-v2.

PURPOSE Recently, the manufacturer of the HDR 192Ir mHDR-v2 brachytherapy source reported small design changes (referred to herein as mHDR-v2r) that are within the manufacturing tolerances but may alter the existing dosimetric data for this source. This study aimed to (1) check whether these changes affect the existing dosimetric data published for this source; (2) obtain new dosimetric data in close proximity to the source, including the contributions from 192Ir electrons and considering the absence of electronic equilibrium; and (3) obtain scatter dose components for collapsed cone treatment planning system implementation. METHODS Three different Monte Carlo (MC) radiation transport codes were used: MCNP5, PENELOPE2008, and GEANT4. The source was centrally positioned in a 40 cm radius water phantom. Absorbed dose and collision kerma were obtained using 0.1 mm (0.5 mm) thick voxels to provide high-resolution dosimetry near (far from) the source. Dose-rate distributions obtained with the three MC codes were compared. RESULTS Simulations of mHDR-v2 and mHDR-v2r designs performed with three radiation transport codes showed agreement typically within 0.2% for r > or = 0.25 cm. Dosimetric contributions from source electrons were significant for r < 0.25 cm. The dose-rate constant and radial dose function were similar to those from previous MC studies of the mHDR-v2 design. The 2D anisotropy function also coincided with that of the mHDR-v2 design for r > or = 0.25 cm. Detailed results of dose distributions and scatter components are presented for the modified source design. CONCLUSIONS Comparison of these results to prior MC studies showed agreement typically within 0.5% for r > or = 0.25 cm. If dosimetric data for r < 0.25 cm are not needed, dosimetric results from the prior MC studies will be adequate.
Identifying Audiences of E-Infrastructures - Tools for Measuring Impact

Research evaluation should take into account the intended scholarly and non-scholarly audiences of the research output. This holds too for research infrastructures, which often aim at serving a large variety of audiences. With research and research infrastructures moving to the web, new possibilities are emerging for evaluation metrics. This paper proposes a feasible indicator for measuring the scope of audiences who use web-based e-infrastructures, as well as the frequency of use. In order to apply this indicator, a method is needed for classifying visitors to e-infrastructures into relevant user categories. The paper proposes such a method, based on an inductive logic program and a Bayesian classifier. The method is tested, showing that the visitors are efficiently classified with 90% accuracy into the selected categories. Consequently, the method can be used to evaluate the use of the e-infrastructure within and outside academia.
RINT-1 Serves as a Tumor Suppressor and Maintains Golgi Dynamics and Centrosome Integrity for Cell Survival

ABSTRACT Faithful mitotic partitioning of the Golgi apparatus and the centrosome is critical for proper cell division. Although these two cytoplasmic organelles are probably coordinated during cell division, supporting evidence of this coordination is still largely lacking. Here, we show that the RAD50-interacting protein, RINT-1, is localized at the Golgi apparatus and the centrosome in addition to the endoplasmic reticulum. To examine the biological roles of RINT-1, we found that the homozygous deletion of Rint-1 caused early embryonic lethality at embryonic day 5 (E5) to E6 and the failure of blastocyst outgrowth ex vivo. About 81% of the Rint-1 heterozygotes succumbed to multiple tumor formation with haploinsufficiency during their average life span of 24 months. To pinpoint the cellular function of RINT-1, we found that RINT-1 depletion by RNA interference led to the loss of the pericentriolar positioning and dispersal of the Golgi apparatus and concurrent centrosome amplification during the interphase. Upon mitotic entry, RINT-1-deficient cells exhibited multiple abnormalities, including aberrant Golgi dynamics during early mitosis and defective reassembly at telophase, increased formation of multiple spindle poles, and frequent chromosome missegregation. Mitotic cells often underwent cell death in part due to the overwhelming cellular defects. Taken together, these findings suggest that RINT-1 serves as a novel tumor suppressor essential for maintaining the dynamic integrity of the Golgi apparatus and the centrosome, a prerequisite to their proper coordination during cell division.
From Sedentary Time to Sedentary Patterns: Accelerometer Data Reduction Decisions in Youth

Aim This study aims to establish evidence-based accelerometer data reduction criteria to accurately assess total sedentary time and sedentary patterns in children. Methods Participants (n = 1057 European children; 9–13 yrs) were invited to wear an accelerometer for at least 6 consecutive days. We explored 1) non-wear time criteria; 2) minimum daily valid wear time; 3) differences between weekday and weekend day; and 4) minimum number of days of accelerometer wear by comparing the effects of commonly used data reduction decisions on total sedentary time, and duration and number of prolonged sedentary bouts. Results More than 60 consecutive minutes of zero counts was the optimal criterion for non-wear time. Increasing the definition of a valid day from 8 to 10 hours wear time hardly influenced the sedentary outcomes, while the sample size of children with more than 4 valid days increased from 69 to 81%. On weekdays, children had on average 1 hour more wear time, 50 minutes more total sedentary time, 26 minutes more sedentary time accumulated in bouts, and 1 more sedentary bout. At least 6 days of accelerometer data were needed to accurately represent weekly sedentary time and patterns. Conclusions Based on our results we recommend 1) a minimum of 60 minutes of consecutive zeros as the most realistic criterion for non-wear time; and 2) including at least six days with minimum eight valid hours to characterize children's usual total sedentary time and patterns, preferably including one weekend day.
Enablers, inhibitors, and perceptions of testing in novice software teams

There are many different approaches to testing software, with different benefits for software quality and the development process. Yet, it is not well understood what developers struggle with when getting started with testing - and why some do not test at all or not as much as would be good for their project. This missing understanding keeps us from improving processes and tools to help novices adopt proper testing practices. We conducted a qualitative study with 97 computer science students. Through interviews, we explored their experiences and attitudes regarding testing in a collaborative software project. We found enabling and inhibiting factors for testing activities, the different testing strategies they used, and novices’ perceptions and attitudes of testing. Students push test automation to the end of the project, thus robbing themselves from the advantages of having a test suite during implementation. Students were not convinced of the return of investment in automated tests and opted for laborious manual tests - which they often regretted in the end. Understanding such challenges and opportunities novices face when confronted with adopting testing can help us improve testing processes, company policies, and tools. Our findings provide recommendations that can enable organizations to facilitate the adoption of testing practices by their members.
SUBSTRATE DEPLETION APPROACH FOR DETERMINING IN VITRO METABOLIC CLEARANCE: TIME DEPENDENCIES IN HEPATOCYTE AND MICROSOMAL INCUBATIONS

The substrate depletion method is a popular approach used for the measurement of in vitro intrinsic clearance (CLint). However, the incubation conditions used in these studies can vary, the consequences of which have not been systematically explored. Initial substrate depletion incubations using rat microsomes and hepatocytes were performed for eight benzodiazepines: alprazolam, clobazam, clonazepam, chlordiazepoxide, diazepam, flunitrazepam, midazolam, and triazolam. Subsequent predictions of in vivo CLint (ranging from 3 to 200 ml/min) and hepatic clearance (CLH) (ranging from 0.3 to 15 ml/min) demonstrated that the general predictive ability of this approach was similar to that of the traditional metabolite formation method. A more detailed study of the substrate depletion profiles and CLint estimates indicated that the concentration of enzyme used is of particular importance. The metabolism of triazolam, clonazepam, and diazepam was monoexponential at all cell densities using hepatocytes; however, with microsomes, biphasic depletion was apparent, particularly at higher microsomal protein concentrations (2-5 mg/ml). Enzyme activity studies indicated that enzyme loss was more pronounced in the microsomal system (ranged from 8 to 65% activity after a 1-h incubation) compared with the hepatocyte system (approximately 100% activity after a 1-h incubation). For clonazepam (a low clearance substrate), these biphasic profiles could be explained by loss of enzyme activity. To ensure accurate predictions of in vivo CLint and CLH when using the substrate depletion approach, based on the results obtained for this class of drugs, it is recommended that low enzyme concentrations and short incubation times are used whenever possible.
Surface velocity monitoring by satellite altimetry and repeated ADCP observations

A method has been developed to monitor the surface velocity by combining satellite altimetry data and repeated acoustic Doppler current profiler (ADCP) observations. First, geostrophic velocity calculated from the altimetry data is compared with the ADCP observations, resulting in their good agreement after adjusting their spatial scales. Then, a set of observations of the temporal mean velocity is obtained by subtracting the altimetry velocity anomaly from the ADCP observations. Regularly sampled time series of surface velocity can be determined by adding the averaged mean velocity and the altimetry anomaly components, which describes variations of the Kuroshio and the Subtropical Countercurrent well.
Cucumber Shaped and 35 nm Particles in Creutzfeldt-Jakob Disease

SUMMARY: A 63 year old female with the ataxic form of Creutzfeldt-Jakob disease (CJD) is presented. In addition to amyloid plaques which were not associated with Alzheimer’s neurofibrillary tangles, rare profiles similar to those reported in Scrapie were also seen. To our knowledge, these profiles have never been observed in CJD and their presence in this condition adds a further morphologic similarity between the human and animal forms of subacute spongiform “viral” encephalopathies.
Interfacial stability and degradation in organic photovoltaic solar cells

Organic photovoltaic (OPV) solar cells show great promise but suffer from short operating lifetimes. This study examines the role that the selection of materials for the hole extraction interface in inverted OPV devices plays in determining the lifetime of a device. In the first part of the study, the effects of thermal degradation were examined. It was found that devices containing MoO3 HTLs and silver top electrodes exhibit an open-circuit voltage (VOC)/fill factor (FF)-driven mechanism. Physical characterisation experiments showed that, with heating, the silver electrode undergoes de-wetting. With thin electrodes this can result in the catastrophic failure of the device. A fracture analysis study found that silver-containing devices experience an increase in adhesion of their top layers to the active layer due to interdiffusion between the layers. This interdiffusion may be related to the loss of VOC and FF in Ag/MoO3 devices through diffused species forming charge traps in the active layer. In the second part of the study, the effects of photodegradation in different atmospheres were studied. Some material-dependent effects were observed when the devices were aged in an inert atmosphere, including variations in projected lifetime. The effect of oxygen was to greatly accelerate degradation, and remove any of the material-dependence observed in the inert experiment, while humidity led to a substantial increase in the degradation rate of devices containing PEDOT:PSS (poly(3,4-ethylenedioxythiophene) polystyrene sulfonate). This study underlines the importance of considering device lifetime in device design, and choosing materials to minimise degradation.
The effects of phytoestrogenic isoflavones on the formation and disposition of paracetamol sulfate in the isolated perfused rat liver

This study examines the potential for the phytoestrogenic isoflavones, a type of complementary medicine, to be involved in pharmacokinetic interactions in the liver. Rat livers were isolated and perfused to steady state, in single‐pass mode, with either 5 μm paracetamol (n=6), or 5 μm paracetamol with a 50:50 molar mixture of genistein and biochanin A or daidzein and formononetin, at a total isoflavone concentration of 1 and 10 μm (n = 6 for each mixture at each concentration). At 1 μm, neither isoflavone mixture had any effect, while at 10 μm both mixtures decreased the clearance of paracetamol and the formation clearance to paracetamol sulfate. Genistein and biochanin A (10 μm) also increased the biliary extraction of hepatically‐generated paracetamol sulfate. Additional livers were perfused with an infusion of 5 μm 14C‐paracetamol in the absence (n = 4), or presence, of a 10 μm genistein and biochanin A mixture (n = 4). Analysis of washout perfusate and bile samples (up to 30min after stopping the infusion) revealed that the isoflavones reduced the first‐order rate constant for paracetamol sulfate transport into perfusate, but not for transport into bile. The results indicate that isoflavones can reduce the formation of paracetamol sulfate and that its enhanced excretion into bile arises from the inhibition of sinusoidal efflux transport.
Effect of High Temperatures on the TRM-to-Masonry Bond

This work is devoted to the experimental assessment of the Textile Reinforced Mortar (TRM)-to-masonry residual bond characteristics as a function of temperature. For this purpose, shear bond tests on single-lap/single-prism specimens were conducted after their exposure at different temperature levels, namely at 100°C, 200°C and 300°C. Specimens consisted of a strip of cementitious mortar reinforced with an uncoated alkali-resistant (AR) glass fiber textile unilaterally bonded on a fired clay brick masonry wallette (prism). For each heating event, a sharp temperature rise rate was opted for the achievement of the target temperature at which the specimens remained for one hour. Reference specimens were also tested at ambient conditions (20°C). Tests were carried out by varying both bond lengths and exposing temperatures. Two specimens were tested for each combination of bond length and exposing temperature. Material characterization tests were also carried out at each temperature level including ambient. The experimental results provide valuable insight on the degradation of the TRM-to-masonry bond capacity following a heating event and on the related failure modes.
Quorum-Sensing Regulation of the Biofilm Matrix Genes (pel) of Pseudomonas aeruginosa

ABSTRACT Quorum sensing (QS) has been previously shown to play an important role in the development of Pseudomonas aeruginosa biofilms (D. G. Davies et al., Science 280:295-298, 1998). Although QS regulation of swarming and DNA release has been shown to play important roles in biofilm development, regulation of genes directly involved in biosynthesis of biofilm matrix has not been described. Here, transcription of the pel operon, essential for the production of a glucose-rich matrix exopolysaccharide, is shown to be greatly reduced in lasI and rhlI mutants. Chemical complementation of the lasI mutant with 3-oxo-dodecanoyl homoserine lactone restores pel transcription to the wild-type level and biofilm formation ability. These findings thus connect QS signaling and transcription of genes responsible for biofilm matrix biosynthesis.