Miracle-dz/UniFAR-FTUs huggingface dataset:
Molecular and Morphological Evidence Challenges the Records of the Extant Liverwort Ptilidium pulcherrimum in Eocene Baltic Amber

Preservation of liverworts in amber, a fossilized tree resin, is often exquisite. Twenty-three fossil species of liverworts have been described to date from Eocene (35–50 Ma) Baltic amber. In addition, two inclusions have been assigned to the extant species Ptilidium pulcherrimum (Ptilidiales or Porellales). However, the presence of the boreal P. pulcherrimum in the subtropical or warm-temperate Baltic amber forest challenges the phytogeographical interpretation of the Eocene flora. A re-investigation of one of the fossils believed to be P. pulcherrimum reveals that this specimen in fact represents the first fossil evidence of the genus Tetralophozia, and thus is re-described here as Tetralophozia groehnii sp. nov. A second fossil initially assigned to P. pulcherrimum is apparently lost, and can be reassessed only based on the original description and illustrations. This fossil is morphologically similar to the extant North Pacific endemic Ptilidium californicum, rather than P. pulcherrimum. Divergence time estimates based on chloroplast DNA sequences provide evidence of a Miocene origin of P. pulcherrimum, and thus also argue against the presence of this taxon in the Eocene. Ptilidium californicum originated 25–43 Ma ago. As a result, we cannot rule out that the Eocene fossil belongs to P. californicum. Alternatively, the fossil might represent a stem lineage element of Ptilidium or an early crown group species with morphological similarities to P. californicum.
Theory of mind in bulimia nervosa.

OBJECTIVE This study aimed to investigate theory of mind (ToM) in individuals with bulimia nervosa (BN), an area neglected by empirical research despite social functioning difficulties in this disorder and evidence of ToM deficits in people with anorexia nervosa (AN). METHOD ToM was assessed in 48 BN and 34 Eating Disorder Not Otherwise Specified BN-type (EDNOS-BN) outpatients and 57 healthy controls (HCs) using the Reading the Mind in the Eyes and the Reading the Mind in the Films (RMF), an ecologically valid task novel to BN research. RESULTS Overall performance in BN and EDNOS-BN groups was equivalent to HCs on both tasks. Individuals with BN had enhanced negative emotion recognition on the RMF. DISCUSSION Individuals with AN and BN have distinct socio-cognitive profiles. Further research into social cognition is required to establish the link between interpersonal difficulties and psychopathology in people with BN.
Modeling Service Quality for Dynamic QoS Publishing

As Web services are widely adopted, the nonfunctional requirements (i.e. QoS constraints) have become a significant factor in implementing trustworthy and predictable service applications. In this paper, we analyze the QoS publishing necessity, and categorize QoS parameters to refine their characteristics. Then we propose a conceptual publishing model, which is adaptive for the distributed and decentralized service-oriented computing environment. We further introduce the perception service quality measurement models, and extend P-E model for web services. The extended model takes both dynamic QoS parameters and customer expectations into consideration. A compensation mechanism is also incorporated into the model for trade-off when nonfunctional requirements cannot be fully satisfied.
Modulation of HSP27 alters hypoxia‐induced endothelial permeability and related signaling pathways

This manuscript describes how the permeability of pulmonary artery microvascular endothelial cell (RPMEC) monolayer is elevated by hypoxia and the role played by HSP27 phosphorylation. p38 MAP kinase activation leading to HSP27 phosphorylation was previously shown by our laboratory to alter the actin cytoskeleton and tethering properties of RPMEC. This effect was independent of hypoxia‐induced contractility which was ROCK‐dependent rather than HSP27‐dependent. Results described here show that increased HSP27 phosphorylation not only does not underlie hypoxia‐induced permeability, but may actually augment the endothelial barrier. Hypoxia causes gap formation between RPMEC and increases MLC2 phosphorylation. The phosphorylation of MYPT1, which inhibits MLC2 phosphatase, is also increased in hypoxia. In addition, FAK phosphorylation, which alters focal adhesion signaling, is increased in hypoxia. Overexpressing phosphomimicking HSP27 (pmHSP27), which induces significant actin stress fiber formation, surprisingly renders RPMEC resistant to hypoxia‐ or TGFβ‐induced permeability. siRNA against pmHSP27 reverses the increased actin stress fiber formation in pmHSP27‐overexpressing cells, and disrupting actin stress fibers in pmHSP27‐overexpressing RPMEC renders them more susceptible to hypoxia. Finally, hypoxia‐induced gap formation, as well as phosphorylation of MLC2, MYPT1 and FAK are almost abolished by overexpressing pmHSP27 in RPMEC. These effects of pmHSP27 overexpression might represent decreased cytoskeletal plasticity and increased tethering which counteracts permeability‐inducing contractility. Thus hypoxia activates two pathways one leading to contractility and increased permeability, the other leading to actin stress fibers, stronger adhesion, and reduced permeability. Altering HSP27 phosphorylation, which tips the balance towards decreased permeability, might be targeted in managing endothelial barrier dysfunction. J. Cell. Physiol. 220: 600–610, 2009. © 2009 Wiley‐Liss, Inc.
Effects of various concentrations of gonadotropins and 17β estradiol on the in vitro maturation of cattle oocytes selected using brilliant cresyl blue staining

The objective of this study was to determine the in vitro maturation rate of cattle oocytes selected with brilliant cresyl blue (BCB) stain, in tissue culture medium 199 (TCM 199) supplemented with various concentrations of hormones. Oocytes were retrieved from abattoir-derived ovaries by aspiration. Oocytes were then exposed to 26 μM BCB stain, and classified according to the colour of their cytoplasm: BCB+ (oocytes with blue cytoplasm) and BCB- (unstained oocytes). The BCB selected and the non-selected immature oocytes were randomly allocated into TCM 199 + 10% foetal bovine serum (FBS) maturation media supplemented with three concentrations of hormones as treatments (T). The T1 group was matured in the presence of 0.5 μg follicle stimulating hormone (FSH)/mL, 5 mg luteinising hormone (LH)/mL and 2 μg estradiol (E 2 )/mL. The T2 group was matured in 1 μg FSH, 6 mg LH and 2.5 μg E 2 /mL. The T3 group was matured in 1.5 μg FSH, 7 mg LH and 4.5 μg E 2 /mL. The maturation rate of oocytes was determined by the protrusion of the first polar bodies 24 h after maturation. Data were analysed by ANOVA using SAS. Treatment 2 yielded higher maturation rates for with BCB+ (30.5%) and without BCB (35%) oocytes, with T1 giving a lower maturation rate for BCB+ (10.7%) and without BCB (9.7%) oocytes. However, BCB- oocytes had lower polar body extrusion (0.7%, 1% and 2.7%) for T1, T2 and T3, respectively. In conclusion, immature oocytes that were exposed to BCB+ and cultured in TCM 199 supplemented with 10% FBS, 1 μg FSH, 6 mg LH and 2.5 μg E 2 /mL had a higher number of matured oocytes (extrusion of first polar body), similar to those that were not exposed to BCB (no BCB). Oocyte selection with BCB staining was a useful test for classifying good-quality cattle oocytes.
Effects of exercise on NMDA receptor subunit contributions to bidirectional synaptic plasticity in the mouse dentate gyrus

We examined synaptic plasticity in the dentate gyrus (DG) of the hippocampus in vitro in juvenile C57Bl6 mice (28–40 days of age), housed in control conditions with minimal enrichment (Controls) or with access to an exercise wheel (Runners). LTP expression was significantly greater in slices from Runners than in those from Controls, but could be blocked by APV in both groups. LTP was significantly reduced by NR2B subunit antagonists in both groups. NVP‐AAM077, an antagonist with a higher preference for NR2A subunits over NR2B subunits, blocked LTP in slices from Runners and produced a slight depression in Control animals. LTD in the DG was also blocked by APV, but not by either of the NR2B specific antagonists. Strikingly, NVP‐AAM077 prevented LTD in Runners, but not in Control animals, suggesting an increased involvement of NR2A subunits in LTD in animals that exercise. NVP‐AAM077 did not block LTD in NR2A Knock Out (KO) animals that exercised, as expected. In an attempt to discern whether NMDA receptors located at extrasynaptic sites could play a role in the induction of LTD, DL‐TBOA was used to block excitatory amino acid transport and increase extracellular glutamate levels. Under these conditions, LTD was not blocked by the co‐application of a specific NR2B subunit antagonist in either group, but NVP‐AAM077 again blocked LTD selectively in Runners. These results indicate that NR2A and NR2B subunits play a significant role in LTP in the DG, and that exercise can significantly alter the contribution of NMDA NR2A subunits to LTD. © 2007 Wiley‐Liss, Inc.
Customized Policies for Handling Partial Information in Relational Databases

Most real-world databases have at least some missing data. Today, users of such databases are “on their own” in terms of how they manage this incompleteness. In this paper, we propose the general concept of partial information policy (PIP) operator to handle incompleteness in relational databases. PIP operators build upon preference frameworks for incomplete information, but accommodate different types of incomplete data (e.g., a value exists but is not known; a value does not exist; a value may or may not exist). Different users in the real world have different ways in which they want to handle incompleteness-PIP operators allow them to specify a policy that matches their attitude to risk and their knowledge of the application and how the data was collected. We propose index structures for efficiently evaluating PIP operators and experimentally assess their effectiveness on a real-world airline data set. We also study how relational algebra operators and PIP operators interact with one another.
Training with anxiety has a positive effect on expert perceptual–motor performance under pressure

In two experiments, we examined whether training with anxiety can prevent choking in experts performing perceptual–motor tasks. In Experiment 1, 17 expert basketball players practised free throws over a 5-week period with or without induced anxiety. Only after training with anxiety did performance no longer deteriorate during the anxiety posttest. In Experiment 2, 17 expert dart players practised dart throwing from a position high or low on a climbing wall, thus with or without anxiety. Again, only after training with anxiety was performance maintained during the anxiety posttest, despite higher levels of anxiety, heart rate, and perceived effort. It is concluded that practising under anxiety can prevent choking in expert perceptual–motor performance, as one acclimatizes to the specific processes accompanying anxiety.
Long-acting Inhaled Bronchodilator and Risk of Vascular Events in Patients With Chronic Obstructive Pulmonary Disease in Taiwan Population

AbstractA combination of long-acting anticholinergic agents (LAACs) and long-acting &bgr;2-adrenergic receptor agonist (LABA) is effective in improving lung function in chronic obstructive pulmonary disease (COPD) compared with monotherapy. However, evidence on whether this combination increases the incidence of stroke or other cardiac events remains sparse. The objective of the present study was to investigate the incidence of stroke and other cardiovascular diseases in COPD patients treated with LAAC, LABA, or a combination of the 2.We conducted this population-based study using the Taiwan National Health Insurance Research Database (1997–2008), identifying COPD patients and their prescribed medication from the International Classification of Disease, Ninth Revision codes 490–492 or 496. A multivariate Cox proportional-hazards model was used to compare the risk of stroke and other cardiovascular diseases over the 11-year period after treatment with LAAC or LABA only or in combination.Of the 596 COPD patients (mean age 70 y), 196 were treated with LAAC, 318 with LABA, and 82 were treated with a combination. The overall incidence of stroke (8.53%) significantly increased in the combination group compared with LAAC (2.04%) or LABA (1.26%) only. In the Cox regression analysis, the adjusted hazard ratio over the 11-year survey period for stroke in patients treated with the combination compared with LABA only was 1.04 (95% confidence interval, 1.06–2.99) and for LAAC, it was 0.31 (95% confidence interval, 0.02–2.32). This cohort study using a large health insurance database showed that treating patients with COPD, with a combination of LAAC and LABA, may be associated with an increased hazard of stroke compared with treatment with either agent alone. We should be particularly cautious about comedication of LAAC and LABA in patients with COPD.
Intra- and interband transfers in the B800-B850 antenna of Rhodospirillum molischianum Redfield theory modeling of polarized pump-probe kinetics

We use an exciton model for the B800−B850 LH2 light-harvesting antenna of Rhodospirillum molischianum to explain the absorption, excitation-wavelength-dependent pump−probe kinetics, and induced absorption anisotropy at 77 K reported previously (Wendling, M.; van Mourik, F.; van Stokkum, I. H. M.; Salverda, J. M.; Michel, H.; van Grondelle, R. Low-intensity pump−probe measurements on the B800 band of Rhodospirillum molischianum. Biophys. J. 2003, 84, 440). The nonlinear response was calculated using the density matrix equation, expanded up to the third-order with respect to the external field, with the Redfield relaxation operator in the exciton basis. The model allowed us to obtain a simultaneous and quantitative fit of the data while taking into account the excitonic interactions, the static disorder, and phonon-induced relaxation of populations and coherences in the one-exciton manifold (including a nonsecular coherence transfer and population-coherence coupling). The spectral density of the exciton−pho.
Does brand differentiate pharmaceuticals?

INTRODUCTION Role of marketing in pharmaceutical industry is increasing and inspiration by successful brands known from consumer goods market influenced pharmaceutical companies enough to switch their attention to branding initiatives. Still there is little evidence that pharmaceutical brands represent anything more than product only. OBJECTIVES AND METHODS This study aims to explore the area of branding in pharmaceutical industry. Central hypothesis of the research has been that brand and its emotional content differentiate pharmaceuticals as well as rational data derived from clinical studies. It has been tested by extensive review of available literature as well as by primary research focused on drivers of physicians' attitudes towards products and their influence on prescribing behavior. The research has been conducted in the sample of psychiatrists in the Czech Republic. RESULTS No evidence about pharmaceutical brand exceeding value of product has been found in reviewed literature. Nevertheless, the primary research conducted in the sample of Czech psychiatrists indicates that emotional brand in pharmaceutical industry exists and enables author to draw a model of Customer/product life cycle that describes likely impact of functional, emotional and self-expressive benefits throughout pharmaceutical product's market presence. CONCLUSIONS Pharmaceutical brand is likely to develop differently than the same of consumer goods products--it seems to be built predominantly on long-term positive experience. Marketing role in this process should lie in finding relevant product position and building brand identity compliant with real product capabilities.
Perinatal death and neurological damage as a sequential chain of poor outcome

Objective: We investigated the risk factors of perinatal death and neurological damage. Methods: Perinatal death and neurological damage were retrospectively investigated using a population-based study of 108 024 deliveries from 1998 to 2007. Main factors studied were asphyxia, growth restriction and preterm delivery < 34 weeks of gestation, since these three factors were most often associated with poor prognosis. The impact of each factor was identified by multiple regression analyses. Results: There were 459 perinatal deaths (4.3/1000) and 220 neurological damages (2.0/1000). Preterm delivery accounted for 50% of perinatal deaths and neurological damage, whereas it constituted 2.6% of total births. Multiple regression analyses showed that prematurity < 34 weeks (10-fold), asphyxia (10-fold) and growth restriction (2-fold) were independent and significant risk factors associated with poor outcomes, and that the magnitude was similar throughout the three consecutive critical events of fetal death, neonatal death and neurological damage. Conclusions: Prematurity < 34 weeks, asphyxia and growth restriction are independent and persistent risk factors from perinatal death to neurological damage.
Social orienting in gaze leading: a mechanism for shared attention

Here, we report a novel social orienting response that occurs after viewing averted gaze. We show, in three experiments, that when a person looks from one location to an object, attention then shifts towards the face of an individual who has subsequently followed the person's gaze to that same object. That is, contrary to ‘gaze following’, attention instead orients in the opposite direction to observed gaze and towards the gazing face. The magnitude of attentional orienting towards a face that ‘follows’ the participant's gaze is also associated with self-reported autism-like traits. We propose that this gaze leading phenomenon implies the existence of a mechanism in the human social cognitive system for detecting when one's gaze has been followed, in order to establish ‘shared attention’ and maintain the ongoing interaction.
Building Social Capital: A Study of the Online Disability Community

There are numerous studies about the relationship between technological aspects of the Internet and disability. However, little is known about the social impact of the Internet on the disability community. Using the theory of social capital, this study aims to understand social aspects of the Internet, specifically its impact on the network building of people with disabilities. Based on survey data from a sample of 122 individuals with disabilities across China, the current study explores the characteristics of social capital in the online disability community and effects of Internet use on building social capital. The findings suggest that the online disability community has high levels of social capital and that greater involvement in online activities can generate higher levels of social capital for people with disabilities.
Task-related “cortical” bursting depends critically on basal ganglia input and is linked to vocal plasticity

Basal ganglia-thalamocortical circuits are critical for motor control and motor learning. Classically, basal ganglia nuclei are thought to regulate motor behavior by increasing or decreasing cortical firing rates, and basal ganglia diseases are assumed to reflect abnormal overall activity levels. More recent studies suggest instead that motor disorders derive from abnormal firing patterns, and have led to the hypothesis that surgical treatments, such as pallidotomy, act primarily by eliminating pathological firing patterns. Surprisingly little is known, however, about how the basal ganglia normally influence task-related cortical activity to regulate motor behavior, and how lesions of the basal ganglia influence cortical firing properties. Here, we investigated these questions in a songbird circuit that has striking homologies to mammalian basal ganglia-thalamocortical circuits but is specialized for singing. The “cortical” outflow nucleus of this circuit is required for song plasticity and normally exhibits increased firing during singing and song-locked burst firing. We found that lesions of the striato-pallidal nucleus in this circuit prevented hearing-dependent song changes. These basal ganglia lesions also stripped the cortical outflow neurons of their patterned burst firing during singing, without changing their spontaneous or singing-related firing rates. Taken together, these results suggest that the basal ganglia are essential not for normal cortical firing rates but for driving task-specific cortical firing patterns, including bursts. Moreover, such patterned bursting appears critical for motor plasticity. Our findings thus provide support for therapies that aim to treat basal ganglia movement disorders by normalizing firing patterns.
Optimality of index policies for stochastic scheduling with switching penalties

We investigate the impact of switching penalties on the nature of optimal scheduling policies for systems of parallel queues without arrivals. We study two types of switching penalties incurred when switching between queues: lump sum costs and time delays. Under the assumption that the service periods of jobs in a given queue possess the same distribution, we derive an index rule that defines an optimal policy. For switching penalties that depend on the particular nodes involved in a switch, we show that although an index rule is not optimal in general, there is an exhaustive service policy that is optimal.