Miracle-dz/UniFAR-FTUs huggingface dataset:
A Role for Perirhinal Cortex in Memory for Novel Object–Context Associations

It is debated whether functional divisions between structures in the medial temporal lobe (MTL), in particular the perirhinal cortex (PrC) and hippocampus (HC), are best conceptualized according to memory process (Diana et al., 2007; Ranganath, 2010; Wixted et al., 2010) or stimulus category (Graham et al., 2010). In the former account, PrC is critical for item familiarity but not recollection of associations between items and their contexts (which is instead dependent upon the HC; Ranganath et al., 2004). In the latter theory, complex object representations in PrC are capable of supporting memory for objects as well as for object–context associations, particularly when there is a demand to discriminate between highly visually similar objects (Cowell et al., 2010). To adjudicate between these accounts, human participants were scanned while making two different judgments about visually presented objects (is the object common or uncommon, or does the object have more edges or curves). In a subsequent, unscanned, retrieval phase, participants made item (old/new) followed by context (encoding task) judgments about previously seen and novel objects. Neural activity at encoding was separated according to the accuracy of the retrieval judgments. PrC activity predicted successful item–context judgments, a result that remained when item-memory strength was equated across objects for which the context was remembered or forgotten. These data imply that the function of PrC goes beyond processing item-based memory information, contributing additionally to memory for item–context associations when the stimuli are objects (Graham et al., 2010).
Human Kin 17 Protein Directly Interacts with the Simian Virus 40 Large T Antigen and Inhibits DNA Replication 1

Kin17 is an evolutionarily conserved DNA-binding protein, which forms intranuclear foci in proliferating cells. Recent data have suggested that human kin17 protein is associated with cell proliferation and unrepaired DNA lesions. Herein, we show that human fibroblasts (MRC5-V2 and CHSV4) immortalized with SV40 overexpress endogenous kin17 protein, as compared with normal diploid human fibroblasts. We observed that certain carcinoma cell lines also up-regulated kin17 protein, suggesting that increased kin17 protein levels may be a consequence of the immortalized phenotype. We report here that the endogenous kin17 protein is located in nucleoplasmic foci and colocalizes with SV40 large T antigen. Purification of human kin17 protein allowed analysis of the physical interaction with T antigen by several in vitro and in vivo assays. Large T antigen and human kin17 protein are part of the same high molecular weight multiprotein complex in human cells. Furthermore, human kin17 protein interacts with T antigen bound to the SV40 DNA origin of replication. Strikingly, the overexpression of human kin17 protein in vivo and the introduction of increased amounts of human kin17 protein in an in vitro assay reduced T-antigen-dependent DNA replication, suggesting that kin17 protein may be involved in the DNA replication process in human cells.
Synergistic Antitumor Activity of Gemcitabine and ABT-737 In Vitro and In Vivo through Disrupting the Interaction of USP9X and Mcl-1

The Bcl-2 antagonist ABT-737 targets Bcl-2/Bcl-xL, but not Mcl-1, which may confer resistance to this agent in various cancers with high levels of Mcl-1. Here, we showed that the combination of gemcitabine and ABT-737 exhibited synergistic cytotoxicity and induced significant apoptosis in multiple cancer types, including lung, renal, bladder, and prostate cancers. The enhanced apoptosis induced by gemcitabine plus ABT-737 was accompanied by the greater extent of mitochondrial depolarization, caspases-3 activation, and PARP cleavage in 95-D and 5637 cell lines. Importantly, in ABT-737–resistant cancer cells, the interaction between USP9X and Mcl-1, which was increased by ABT-737 treatment, could be disrupted by gemcitabine, thus resulting in enhanced ubiquitination and the subsequent degradation of Mcl-1 and ultimately in the synergism of these two drugs. Moreover, the increased anticancer efficacy of gemcitabine combined with ABT-737 was further validated in a human lung cancer 95-D xenograft model in nude mice. Taken together, our data first showed the synergistic anticancer capabilities achieved by combining gemcitabine and ABT-737 and, second, opened new opportunities to use antiapoptotic Bcl-2 family members, which drive tumor cell resistance in current anticancer therapies, therapeutically. Mol Cancer Ther; 10(7); 1264–75. ©2011 AACR.
A Randomized Controlled Trial of a Therapist- Assisted Internet Cognitive Behaviour Therapy Program for Women with Postpartum Depression

Postpartum depression (PPD) impacts up to 15% of Canadian women following childbirth. The debilitating disorder not only impacts the woman, but also is related to shortand long-term consequences of her infant‘s development. A systematic review of psychological treatments for PPD demonstrated symptomatic improvements from preto post-treatment and superiority to control conditions (Sockol, Epperson, & Barber, 2011). Remarkably, many women suffering from PPD do not receive appropriate treatment. Internet and computer-based delivery formats are an innovative way to improve access to psychological treatment. While therapist-assisted Internet cognitive behaviour therapy (TAICBT) has proven more efficacious than a controlled waitlist condition to treat depressive symptoms reported by mothers of young children (Sheeber et al., 2012), research has not investigated TAICBT for PPD. The current study examined the efficacy of TAICBT for the treatment of PPD reported by Saskatchewan women who have a child less than one year of age. Using a randomized control design, women (N = 50) scoring above 10 on the Edinburgh Postnatal Depression Scale (EPDS) were randomly assigned to receive either TAICBT or waitlist control (WLC). The efficacy of the treatment was investigated at baseline and at sevento 10-week follow-up. Treatment satisfaction, therapeutic alliance, and open-ended questions regarding participant experiences with the program were explored at posttreatment. For a longer-term follow-up, TAICBT participants were contacted four-weeks following treatment completion. Analyses included multi-level mixed models, clinical significance testing, multiple regressions, and thematic content analysis of the openended responses. Results indicated that symptoms of PPD tended to decrease more
Different Worlds and Divergent Paths: Academic Careers Defined by Race and Gender

In this article, Juanita Johnson-Bailey, a Black female professor, and Ronald M. Cervero, a White male professor, examine and contrast their academic lives by exploring how race and gender have influenced their journeys and their experiences. Using journal excerpts, personal examples, and a comparative list of privileges, the authors present a picture of their different realities at a research university. The depiction of their collective forty years in academia reveals that White men and Black women are regarded and treated differently by colleagues and students. Manifestations of this disparate treatment are evident primarily in classroom and faculty interactions. An examination of the professors' relationships with people and with their institution illustrates that, overall, the Black woman is often relegated to a second-class existence characterized by hostility, isolation, and lack of respect, while the White man lives an ideal academic life as a respected scholar who disseminates knowledge, understa.
Introducing Vygotsky: A Guide for Practitioners and Students in Early Years Education

Introduction Glossary 1. The early life and times of Jerome Bruner 2. The life of the mind of Jerome Bruner 3. Mind and meaning 4. Brilliant babies 5. From communicating to talking 6. Learning to name and reference 7. Learning to ask and to question 8. Pedagogy: Teaching and Learning 9. Narrative: the making of stories A final word
EP for Efficient Stochastic Control with Obstacles

We address the problem of continuous stochastic optimal control in the presence of hard obstacles. Due to the non-smooth character of the obstacles, the traditional approach using dynamic programming in combination with function approximation tends to fail. We consider a recently introduced special class of control problems for which the optimal control computation is reformulated in terms of a path integral. The path integral is typically intractable, but amenable to techniques developed for approximate inference. We argue that the variational approach fails in this case due to the non-smooth cost function. Sampling techniques are simple to implement and converge to the exact results given enough samples. However, the infinite cost associated with hard obstacles renders the sampling procedures inefficient in practice. We suggest Expectation Propagation (EP) as a suitable approximation method, and compare the quality and efficiency of the resulting control with an MC sampler on a car steering task and a ball throwing task. We conclude that EP can solve these challenging problems much better than a sampling approach.
Batting performance of wood and metal baseball bats.

INTRODUCTION/PURPOSE Although metal baseball bats are widely believed to outperform wood bats, there are few scientific studies which support this. In a batting cage study, Greenwald et al. found that baseballs hit with a metal bat traveled faster than those hit with a wood bat, but the factors responsible for this difference in bat performance remain unidentified. The purpose of this study was to determine the effects of swing speed, impact location, and elastic properties of the bat on batted ball speeds. METHODS The pitched ball, batted ball, and swings of two wood and five metal baseball bats by 19 different players were tracked in three dimensions at 500 Hz using a passive infrared motion analysis system. RESULTS Increases in the batted ball speeds of metal bats over those of wood bats resulted from faster swing speeds and higher elastic performance with an apparent increase in the ball-bat coefficient of restitution. The contribution of these variables to batted ball speed differed with metal bat model. The "sweet spot" associated with maximum batted ball speeds was located approximately the same distance from the tip of wood bats as it was from metal bats. CONCLUSIONS The variables that correlated with differences between metal and wood bat performance, and most notably differences in the percentage of faster batted balls, were identified using a novel kinematic analysis of the ball and bat. These variables and their correlation with bat performance should be applicable to other players and bats, although more skilled players and higher performing bats would likely result in even faster batted ball speeds.
Dissecting the Brain's Internal Clock: How Frontal–Striatal Circuitry Keeps Time and Shifts Attention

The ability of organisms to time and coordinate temporal sequences of events and to select particular aspects of their internal and external environments to which they will attend is vital to the organism's ability to adapt to the world around them. Numerous psychological theories have been proposed that describe how organisms might accomplish such stimulus selection and represent discrete temporal events as well as rhythm production. In addition, a large number of studies have demonstrated that damage to the frontostriatal circuitry appears to compromise the ability of organisms to successfully shift attention and behavior to adapt to changing temporal contexts. This suggests that frontostriatal circuitry is involved in the ability to make such shifts and to process temporal intervals. A selective review is accomplished in this article which focuses upon the specific neural mechanisms that may be involved in interval timing and set shifting. It is concluded that prefrontal cortex, substantia nigra pars compacta, pedunculopontine nucleus, and the direct and indirect pathways from the caudate to the thalamus may provide the neuroanatomical and neurophysiological substrates that underlie the organism's ability to shift its attention from one temporal context to another.
Unsuspected pulmonary embolism on CT scanning : yet another headache for clinicians ?

histopathology of chronic cough: a prospective, controlled, comparative study.Chest2006;130:362–70. 6 Chaudhuri R, McMahon AD, Thomson LJ, et al. Effect of inhaled corticosteroids on symptom severity and sputum mediator levels in chronic persistent cough. J Allergy Clin Immunol 2004;113:1063–70. 7 Birring SS, Parker D, Brightling CE, et al. Induced sputum inflammatory mediator concentrations in chronic cough. Am J Respir Crit Care Med 2004;169:15–9. 8 Chaudhuri R, McMahon AD, McSharry CP, et al. Serum and sputum neurotrophin levels in chronic persistent cough. Clin Exp Allergy 2005;35:949–53.
Information technology maturity stages and enterprise benchmarking: an empirical study

Purpose – Recently, many enterprises are using a variety of methods and techniques to examine and improve their current maturity level of information technology (IT). Although IT evaluation studies based on IT maturity stages have been conducted widely, the stages theory has not been confirmed through statistical testing. IT evaluation activities can present managerial implications to an enterprise by determining where it stands within the stages theory. The purpose of this paper is to test empirically and repeatedly the once‐defined maturity model in order to make its validity more powerful.Design/methodology/approach – To define IT maturity stages and benchmarks with statistical testing, evaluation fields and factors of the L&K Model are referred to. Data were gathered by a questionnaire survey and interviews, in which 312 enterprises in South Korea participated. Consequently, IT maturity stages are defined and significant benchmarks of each stage are validated through ANOVA and post hoc comparison meth.
Size reduction of a semiconductor nanowire laser by using metal coating

We explore the possibility of coating semiconductor nanowires with metal (Ag) to reduce the size of nanowire lasers operating at photon energies around 0.8-2 eV. Our results show that the material gain of a typical III-V semiconductor in nanowire may be sufficient to compensate Joule losses of such metal as Ag. The most promising mode to achieve lasing is TM01 near its cutoff. To calculate the guiding properties of metal coated nanowires, we developed a finite-difference discretization approach, the details of which we also present. This approach allowed us to treat accurately the large index contrast of the nanowire/metal interface and to include nonperturbatively the imaginary parts of dielectric constants of the semiconductor core and metal coating.
Non-linear PCA: a missing data approach

MOTIVATION Visualizing and analysing the potential non-linear structure of a dataset is becoming an important task in molecular biology. This is even more challenging when the data have missing values. RESULTS Here, we propose an inverse model that performs non-linear principal component analysis (NLPCA) from incomplete datasets. Missing values are ignored while optimizing the model, but can be estimated afterwards. Results are shown for both artificial and experimental datasets. In contrast to linear methods, non-linear methods were able to give better missing value estimations for non-linear structured data. APPLICATION We applied this technique to a time course of metabolite data from a cold stress experiment on the model plant Arabidopsis thaliana, and could approximate the mapping function from any time point to the metabolite responses. Thus, the inverse NLPCA provides greatly improved information for better understanding the complex response to cold stress. CONTACT scholz@mpimp-golm.mpg. de.
Glutathione S-Transferase M 1 Status and Lung Cancer Risk : A Meta-Analysis

Abstract Interindividual differences in lung cancer susceptibility may be mediated in part through polymorphic variability in the bioactivation of procarcinogens. GSTM1 status has been extensively studied in this context as a lung cancer risk factor, although published studies have produced conflicting results. To clarify the impact of GSTM1 status on lung cancer risk a meta-analysis of 23 case-control studies from the literature has been carried out using a random effects model. The principal outcome measure was the odds ratio for the risk of lung cancer. There was heterogeneity between the studies attributable to differences in the methods of assigning GSTM1 status. Pooling the studies that were based on phenotyping methods, the overall odds ratio of lung cancer risk associated with GSTM1 deficiency was 2.12 (95% confidence interval, 1.43–3.13). The risk of lung cancer risk associated withGSTM1 deficiency derived from the studies based on genotyping methods was, however, lower. The overall odds ratio was 1.13 (95% confidence interval, 1.04–1.25). These findings suggest that the estimates of lung cancer risk associated with GSTM1 deficiency in the early studies, based on phenotyping, were overinflated. Moreover, it is conceivable, given publication bias, that GSTM1 status has no effect on the risk of lung cancer per se. A major concern in casecontrol studies of polymorphisms and cancer risk is bias. A review of the 23 case-control studies indicates that greater attention should, therefore, be paid to the design of future studies.
Number-space mapping in the newborn chick resembles humans’ mental number line

Even chicks may count from left to right For the most part, humans represent numbers across a mental number line, with smaller numbers on the left and larger numbers on the right. Some have argued that this is due to culture rather than being innate. Rugani et al., however, show that 3-day-old chicks share this representation of numbers, consistently seeking lower numbers to the left of a target and larger numbers to the right (see the Perspective by Brugger). These results suggest that there may be an innate spatial representation of numerical values that we share with other animals. Science, this issue p. 534; see also p. 477 Baby chicks also “count” from left to right. [Also see Perspective by Brugger] Humans represent numbers along a mental number line (MNL), where smaller values are located on the left and larger on the right. The origin of the MNL and its connections with cultural experience are unclear: Pre-verbal infants and nonhuman species master a variety of numerical abilities, supporting the existence of evolutionary ancient precursor systems. In our experiments, 3-day-old domestic chicks, once familiarized with a target number (5), spontaneously associated a smaller number (2) with the left space and a larger number (8) with the right space. The same number (8), though, was associated with the left space when the target number was 20. Similarly to humans, chicks associate smaller numbers with the left space and larger numbers with the right space.
Hope and Hopelessness: Critical Clinical Constructs

PART ONE: CONCEPTUAL AND THEORETICAL ISSUES Hope An Overview of the Construct Hopelessness An Overview of the Construct PART TWO: ASSESSMENT AND INTERVENTIONS IN HOPE AND HOPELESSNESS Critique of Existing Measures Assessment in the Clinical Setting Interventions in the Clinical Setting PART THREE: RESEARCH ON HOPE AND HOPELESSNESS Quantitative Research Conducted on Hope and Hopelessness Qualitative Research Conducted on Hope and Hopelessness Directions for Future Research
The Polymerase Activity of Mammalian DNA Pol ζ Is Specifically Required for Cell and Embryonic Viability

DNA polymerase ζ (pol ζ) is exceptionally important for maintaining genome stability. Inactivation of the Rev3l gene encoding the polymerase catalytic subunit causes a high frequency of chromosomal breaks, followed by lethality in mouse embryos and in primary cells. Yet it is not known whether the DNA polymerase activity of pol ζ is specifically essential, as the large REV3L protein also serves as a multiprotein scaffold for translesion DNA synthesis via multiple conserved structural domains. We report that Rev3l cDNA rescues the genomic instability and DNA damage sensitivity of Rev3l-null immortalized mouse fibroblast cell lines. A cDNA harboring mutations of conserved catalytic aspartate residues in the polymerase domain of REV3L could not rescue these phenotypes. To investigate the role of REV3L DNA polymerase activity in vivo, a Rev3l knock-in mouse was constructed with this polymerase-inactivating alteration. No homozygous mutant mice were produced, with lethality occurring during embryogenesis. Primary fibroblasts from mutant embryos showed growth defects, elevated DNA double-strand breaks and cisplatin sensitivity similar to Rev3l-null fibroblasts. We tested whether the severe Rev3l-/- phenotypes could be rescued by deletion of DNA polymerase η, as has been reported with chicken DT40 cells. However, Rev3l-/- Polh-/- mice were inviable, and derived primary fibroblasts were as sensitive to DNA damage as Rev3l-/- Polh+/+ fibroblasts. Therefore, the functions of REV3L in maintaining cell viability, embryonic viability and genomic stability are directly dependent on its polymerase activity, and cannot be ameliorated by an additional deletion of pol η. These results validate and encourage the approach of targeting the DNA polymerase activity of pol ζ to sensitize tumors to DNA damaging agents.
Space‐Time Bifurcation Lines for Extraction of 2D Lagrangian Coherent Structures

We present a novel and efficient technique to extract Lagrangian coherent structures in two‐dimensional time‐dependent vector fields. We show that this can be achieved by employing bifurcation line extraction in the space‐time representation of the vector field, and generating space‐time bifurcation manifolds therefrom. To show the utility and applicability of our approach, we provide an evaluation of existing extraction techniques for Lagrangian coherent structures, and compare them to our approach.
Validation of World Health Organisation HIV/AIDS Clinical Staging in Predicting Initiation of Antiretroviral Therapy and Clinical Predictors of Low CD4 Cell Count in Uganda

Introduction The WHO clinical guidelines for HIV/AIDS are widely used in resource limited settings to represent the gold standard of CD4 counts for antiviral therapy initiation. The utility of the WHO-defined stage 1 and 2 clinical factors used in WHO HIV/AIDS clinical staging in predicting low CD4 cell count has not been established in Uganda. Although the WHO staging has shown low sensitivity for predicting CD4<200cells/mm3, it has not been evaluated at for CD4 cut-offs of <250cells/mm3 or <350 cells/mm3. Objective To validate the World Health Organisation HIV/AIDS clinical staging in predicting initiation of antiretroviral therapy in a low-resource setting and to determine the clinical predictors of low CD4 cell count in Uganda. Results Data was collected on 395 participants from the Joint Clinical Research Centre, of whom 242 (61.3%) were classified as in stages 1 and 2 and 262 (68%) were females. Participants had a mean age of 36.8 years (SD 8.5). We found a significant inverse correlation between the CD4 lymphocyte count and WHO clinical stages. The sensitivity the WHO clinical staging at CD4 cell count of 250 cells/mm3 and 350cells/mm3 was 53.5% and 49.1% respectively. Angular cheilitis, papular pruritic eruptions and recurrent upper respiratory tract infections were found to be significant predictors of low CD4 cell count among participants in WHO stage 1 and 2. Conclusion The WHO HIV/AIDS clinical staging guidelines have a low sensitivity and about half of the participants in stages 1 and 2 would be eligible for ART initiation if they had been tested for CD4 count. Angular cheilitis and papular pruritic eruptions and recurrent upper respiratory tract infections may be used, in addition to the WHO staging, to improve sensitivity in the interim, as access to CD4 machines increases in Uganda.