Miracle-dz/UniFAR-FTUs huggingface dataset:
Interlaboratory and Interstudy Reproducibility of a Novel Lateral-Flow Device and Influence of Antifungal Therapy on Detection of Invasive Pulmonary Aspergillosis

ABSTRACT Interest in lateral-flow devices (LFDs) as potential point-of-care assays for the diagnosis of infectious diseases has increased. Our objective was to evaluate the interlaboratory and interstudy reproducibility and the effects of antifungal therapy on an LFD developed for invasive pulmonary aspergillosis (IPA) detection. An established neutropenic guinea pig model of IPA caused by Aspergillus fumigatus was used. At predetermined time points (1 h and 3, 5, and 7 days postinoculation), blood and bronchoalveolar lavage (BAL) fluid were collected from infected and uninfected animals. In a separate experiment, guinea pigs were treated with posaconazole (10 mg/kg of body weight orally [p.o.] twice a day [BID]), voriconazole (10 mg/kg p.o. BID), liposomal amphotericin B (10 mg/kg intraperitoneally [i.p.] once a day [QD]), or caspofungin (2 mg/kg i.p. QD), and samples were collected on days 7 and 11. Each laboratory independently evaluated the IgG monoclonal antibody-based LFD. Galactomannan and (1→3)-β-d-glucan were also measured using commercially available kits. Good interlaboratory agreement was observed with the LFD, as the results for 97% (32/33) of the serum and 78.8% (26/33) of the BAL fluid samples from infected animals were in agreement. Good interstudy agreement was also observed. The serum sensitivity of each surrogate-marker assay was reduced in animals treated with antifungals. In contrast, these markers remained elevated within the BAL fluids of treated animals, which was consistent with the fungal burden and histopathology results. These results demonstrate that the LFD assay is reproducible between different laboratories and studies. However, the sensitivity of this assay and other markers of IPA may be reduced with serum in the presence of antifungal therapy.
Caveolin‐1 mediates tissue plasminogen activator‐induced MMP‐9 up‐regulation in cultured brain microvascular endothelial cells

Thrombolysis with tissue plasminogen activator (tPA) increases matrix metalloproteinase‐9 (MMP‐9) activity in the ischemic brain, which exacerbates blood‐brain barrier injury and increases the risk of symptomatic cerebral hemorrhage. The mechanism through which tPA enhances MMP‐9 activity is not well understood. Here we report an important role of caveolin‐1 in mediating tPA‐induced MMP‐9 synthesis. Brain microvascular endothelial cell line bEnd3 cells were incubated with 5 or 20 μg/ml tPA for 24 hrs before analyzing MMP‐9 levels in the conditioned media and cellular extracts by gelatin zymography. tPA at a dose of 20 μg/mL tPA, but not 5 μg/mL, significantly increased MMP‐9 level in cultured media while decreasing it in cellular extracts. Concurrently, tPA treatment induced a 2.3‐fold increase of caveolin‐1 protein levels in endothelial cells. Interestingly, knockdown of Cav‐1 with siRNA inhibited tPA‐induced MMP‐9 mRNA up‐regulation and MMP‐9 increase in the conditioned media, but did not affect MMP‐9 decrease in cellular extracts. These results suggest that caveolin‐1 critically contributes to tPA‐mediated MMP‐9 up‐regulation, but may not facilitate MMP‐9 secretion in endothelial cells. Thrombolysis with tissue plasminogen activator (tPA) increases matrix metalloproteinase‐9 (MMP‐9) activity in the ischemic brain, which exacerbates ischemic blood brain barrier (BBB) injury and increases the risk of symptomatic cerebral hemorrhage. Our results suggest a novel mechanism underlying this tPA‐MMP 9 axis. In response to tPA treatment, caveolin‐1 protein levels increased in endothelial cells, which mediate MMP‐9 mRNA up‐regulation and its secretion into extracellular space. Caveolin‐1 may, however, not facilitate MMP‐9 secretion in endothelial cells. Our data suggest caveolin‐1 as a novel therapeutic target for protecting the BBB against ischemic damage. The schematic outlines tPA‐induced MMP‐9 upreguation.
A Place to Call Home: Identification With Dwelling, Community, and Region

The concept of place identity has been the subject of a number of empirical studies in a variety of disciplines, but there have been relatively few attempts to integrate this literature into a more general theory of identity and environment. Such endeavors have been limited by a lack of studies that simultaneously examine identification with places of different scale. This article addresses this critical omission by analyzing how residents of Cape Cod, Massachusetts, develop a sense of home with respect to dwelling, community, and region. Our results suggest that different social and environmental factors discriminate identification across place loci: specifically, that demographic qualities of residents and interpretive residential affiliations are critical to dwelling identity; that social participation in the local community is essential for community identity; and that patterns of intercommunity spatial activity promote a regional identity. Such understandings, we propose, are important to constructin.
Inducing Grammars from Linguistic Universals and Realistic Amounts of Supervision

The best performing NLP models to date are learned from large volumes of manually-annotated data. For tasks like part-of-speech tagging and grammatical parsing, high performance can be achieved with plentiful supervised data. However, such resources are extremely costly to produce, making them an unlikely option for building NLP tools in under-resourced languages or domains. This dissertation is concerned with reducing the annotation required to learn NLP models, with the goal of opening up the range of domains and languages to which NLP technologies may be applied. In this work, we explore the possibility of learning from a degree of supervision that is at or close to the amount that could reasonably be collected from annotators for a particular domain or language that currently has none. We show that just a small amount of annotation input — even that which can be collected in just a few hours — can provide enormous advantages if we have learning algorithms that can appropriately exploit it. This work presents new algorithms, models, and approaches designed to learn grammatical information from weak supervision. In particular, we look at ways of intersecting a variety of different forms of supervision in complementary ways, thus lowering the overall annotation burden. Sources of information include tag dictionaries, morphological analyzers, constituent bracketings, and partial tree annotations, as well as unannotated corpora. For example, we present algorithms that are able to combine faster-to-obtain type-level annotation with unannotated text to remove the need for slower-to-obtain token-level annotation. v Much of this dissertation describes work on Combinatory Categorial Grammar (CCG), a grammatical formalism notable for its use of structured, logic-backed categories that describe how each word and constituent fits into the overall syntax of the sentence. This work shows how linguistic universals intrinsic to the CCG formalism itself can be encoded as Bayesian priors to improve learning.
Transformations in Network Governance: The Case of Migration Intermediaries

Market liberalisation has fundamentally changed state interventions in the supply of services and supportive infrastructure across a range of public services. While this trend has been relatively well documented, there has been a dearth of research into the changing nature of state interventions in migration and mobility. Indeed, the increasing presence of migration intermediaries to service the many and varied needs of migrant workers, particularly skilled migrants, remains significantly under-researched both theoretically and empirically. In providing an analysis of the location, role and changing nature of migration intermediaries, we highlight the implications of commercially driven governance structures. In particular, we suggest that the shift from government to network governance has important implications for skilled migration including greater dependence on (largely unregulated) private intermediaries and variable access to information regarding the process of migration and labour market integration. Accordingly, we present empirical examples of migration intermediaries to illustrate their role and the relationship with and implications of their exchange with migrants.
Institutional Pressures and Isomorphic Change: An Empirical Test

This paper examines the process of isomorphic change. It does so by examin ing the dynamics of the change process and looking at change holistically. Using a population of 36 national-level sport organizations, subject to environ mental pressures from a state agency to adopt a more professional and bureau cratic design, the paper shows that over time there is an increase in the level of homogeneity of these organizations. Although the general shift is to a more professional and bureaucratic type of organization, certain elements of struc ture do not change as much as others, thus demonstrating resistance to institu tional pressures. The processes by which the changes that occurred took place are explored.
Cutting Edge: Limiting Amounts of IL-7 Do Not Control Contraction of CD4+ T Cell Responses1

During the acute T cell response most effector T cells die while some survive and become memory T cells. Selective expression of CD127 (IL-7Rα) on effector T cells has been proposed to engender their survival into the memory pool. We assessed the role of IL-7 in effector T cell survival using MHC class II tetramers to track a CD4+ T cell response following infection with a recombinant vaccinia virus (rVV-2W1S). Exogenous IL-7 prevented the contraction of the 2W1S-specific CD4+ T cell response after rVV-2W1S infection. IL-7 increased proliferation of, and Bcl-2 expression within, 2W1S-specific T cells; the latter was required for IL-7-driven prevention of contraction. Conversely, in vivo neutralization of IL-7 or Bcl-2 did not exacerbate the contraction of 2W1S-specific CD4+ T cells. These data suggest that IL-7 administration may enhance the survival of effector T cells but that IL-7 is not the limiting factor during normal contraction of the response.
Partitioning of Bronchopulmonary Carcinoids in Two Different Prognostic Categories by Ki-67 Score

Introduction: Histological distinction between typical and atypical bronchopulmonary carcinoids is based on mitotic activity and necrosis. Regardless of these two parameters, outcome after surgery is often unpredictable. In this study the prognostic value of different clinico-pathological factors was retrospectively analyzed in a large series of patients with bronchopulmonary carcinoid. Materials and Methods: The long-term post-surgical outcome of 106 radically treated patients affected by bronchopulmonary carcinoid from two Italian centers was correlated with tumor characteristics assessed by combining conventional histology with a panel of immunohistochemical markers of neuroendocrine differentiation (chromogranin-A, NSE) and proliferation activity (Ki-67 score). Results: Carcinoids were assessed as typical (TC = 75; 70.8%) and atypical (AC = 31; 29.2%). Mean follow-up was 8.3 years (range: 0–20; median: 8.0). All cases expressed neuroendocrine markers. At univariate analysis, tumor recurrence [14/75 TC (18.7%), 15/31 AC (48.4%)] correlated with carcinoid histotype (P = 0.003), tumor size (P = 0.012), mitotic index (P = 0.044), Ki-67 score (P < 0.0001), and synchronous node metastasis (P = 0.037). Of these, Cox multivariate analysis confirmed only Ki-67 score as independent predictor of disease recurrence (P = 0.009). The best cut-off for Ki-67 score (calculated by ROC curves) discriminating recurrent vs non-recurrent disease was 4% (sensitivity 79.3%; specificity 83.8%; area under the curve 0.85). By stratifying patients according to this cut-off, a significantly different disease-free survival was found (log-rank test P < 0.0001). Conclusion: Ki-67 score accurately separates bronchopulmonary carcinoids in two well-distinct histo-prognostic categories. Ki-67 score predicts the patients outcome better than mitotic count, histotype, and tumor stage and it is therefore helpful in establishing the appropriate follow-up.
The effects of social TV on television advertising effectiveness

Social TV is the use of communication devices to connect with family and friends watching other TV screens. Plausible arguments suggest both positive and negative effects of social TV viewing on ad-effectiveness. This study contributes by providing evidence for the direction of social TV's effects. The results of a controlled laboratory experiment suggest that the benefits of social TV, principally its association with live TV and therefore less ad-avoidance, come at the cost of negative distraction effects. Like normal coviewing, social TV viewing distracts from ad-processing, reducing unaided recall and brand attitude favorability, compared to individual (solus) viewing. However, social TV messaging about ads improved brand attitude. Perceived creativity increased the likelihood of ad-related messaging. Social TV also has an additional source of distraction, multitasking, but in this study, multitasking did not further reduce ad-effectiveness compared to coviewing. The paper concludes with implications for advertisers and future research.
Bowling Ninepins in Tocqueville's Township

Despite elevating Alexis de Tocqueville to iconic status in our national debate on civic engagement, we have frequently neglected the range and depth of his associational thought. In this essay, I trace the early manifestations and evolution from 1828 to 1840 of his understanding of the commune or township, a featured source of public participation and cohesion within his larger associational lexicon. I show how his reflections on local liberties, in general, and the New England township, in particular, inspired and helped to shape both volumes of his Democracy in America. I emphasize the degree to which Tocqueville saw the participatory vector originating in the township's political life as galvanizing an ardent civic spirit leading to cultural, intellectual, and economic achievements. I conclude by seeking to connect lessons gleaned from Tocqueville's township to contemporary strategies to strengthen citizen participation.For their early encouragement and advice, I thank Clark Gilpin and David Tracy, leaders of the Brauer Seminar at the University of Chicago Divinity School where I presented an initial version of this essay in spring 1994. I am grateful to the late François Furet, who also commented upon that early paper, and Ralph Lerner, who read and notated each of its successive formulations, for their generous and sage oversight of my ensuing Tocquevillian studies. I also thank three anonymous reviewers and the editor of this journal for their comments and constructive criticisms.
The Nature and Severity of Self-Reported Embarrassing Circumstances

To create a comprehensive catalogue of embarrassing predicaments, descriptions of recent embarrassments were obtained from 350 high school and college student respondents. Four major dimensions of embarrassing circumstances emerged, involving individual, interactive, audience, and bystander behavior The respondents' embarrassability predicted the intensity of their embarrassments; in addition, high school students suffered stronger embarrassments than college students, and women reported stronger embarrassments than men. Altogether the 12 subcategories of social predicaments delineated here appear to fit a social esteem model of embarrassment more parsimoniously than an awkward interaction model.
Revisiting the `Physical Activity, Sexual Health, Teenage Identity Construction Nexus'

Teenage sexual activity and pregnancy are aspects of a perceived health crisis among youth in the United Kingdom. One suggested `solution' to this `problem' is grounded in a belief that participation in sport may delay sexual activity and reduce teenage pregnancies. This study examines the validity of this specific proposal, and the surrounding rhetoric of risk, which justify increased surveillance of young people and may have implications for their emergent adult identity. The article suggests that there is a lack of convincing evidence for a clear relationship between sport and sexual activity, and questions the social construction of `youth' which frames these recommendations.
Greenpeace Greenspeak: A Transcultural Discourse Analysis

This cross-cultural discourse analysis examines the construction of environmental issues on Greenpeace web pages in China, Japan and Germany. To uncover the semantic representation of environmental activism on these sites, the authors sought to identify discursive homogeneity and divergence and to bring to light embedded cultural assumptions. The sites were examined between January and July 2003 to the fifth level. Multiple readings considered figures of style, lexical choices and lexical style, visual aspects, and topic and themes. The conclusion discusses the adeptness of localising and regionalising Greenpeace discourses but also points to a visible fragmentisation of environmental discourses as well as inherent inabilities to transcend highly localised understandings of the role of humans in nature. Most significantly, the study illustrates the discursive weight of implicit social and natural hierarchies.
Religious Cognition and Behaviour in Autism: The Role of Mentalizing

ABSTRACT Mentalizing, or theory of mind, has been argued to be critical for supporting religious beliefs and practices involving supernatural agents. As individuals with autism spectrum conditions have been found to have deficits in mentalizing, this raises the question as to how they may conceive of gods and behave in relation to gods. To examine this, we compared high-functioning individuals with autism spectrum conditions (HFA) to typically developing individuals across seven key aspects of religious cognition and behaviour: (a) strength of belief, (b) anthropomorphism of god concepts, (c) felt closeness toward the god, (d) prayer habits, (e) attraction to prayer, (f) efficacy of prayer, and (g) a sense of agency while praying. A battery of mentalizing tasks was administered to measure mentalizing ability, along with the Autism-Spectrum Quotient. As expected, typically developing subjects performed better than HFA subjects in the advanced mentalizing task. However, no statistically significant differences were found with first-order and second-order false belief tasks. In contrast to our predictions and previous research on the religiosity of HFA, we found very little differences between the groups in their religious cognition and behaviour. Moreover, the relationship between mentalizing ability and most of our measures of religious cognition and behaviour was weak and negative. Our data suggest that HFA's deficits in mentalizing appear to have only minimal impact on the way they interact and think about gods. We end the article by reevaluating the role mentalizing may have in religious cognition and behaviour.
Ear dominance and intensity independence in the perception of dichotic chords.

The perceived pitch mixture of two tones of a dichotically presented chord was studied as a function of the difference between the intensities of the right and left ear tones (ΔI). Previous experiments have shown that, within a wide range of ΔI, the pitch mixture is independent of ΔI. This intensity independence of the pitch mixture of dichotic chords is not seen with monaural chords. Within the range of ΔI over which intensity independence is seen, the pitch mixture of the dichotic chord is determined by another property of the central pitch processor—the ear dominance function. In previous experiments the intensity independent function could only be detected in those subjects with a weak ear dominance function. In the present experiments subjects adjusted the relative intensities of the two tones of a binaural chord to match the pitch mixture of a dichotic chord. Using this method, the intensity independent function was measured directly in all subjects. In addition, the present method provides a direct.
Effects of Sewage Discharge on Trophic State and Water Quality in a Coastal Ecosystem of the Gulf of California

This paper provides evidence of the effects of urban wastewater discharges on the trophic state and environmental quality of a coastal water body in a semiarid subtropical region in the Gulf of California. The concentrations of dissolved inorganic nutrients and organic matter from urban wastewater primary treatment were estimated. La Salada Cove was the receiving water body and parameters measured during an annual cycle were temperature, salinity, dissolved oxygen, nitrite, nitrate, ammonia, orthophosphate, and chlorophyll a. The effects of sewage inputs were determined by using Trophic State Index (TRIX) and the Arid Zone Coastal Water Quality Index (AZCI). It was observed that urban wastewater of the city of Guaymas provided 1,237 ton N yr−1 and 811 ton P yr−1 and TRIX indicated that the receiving water body showed symptoms of eutrophication from an oligotrophic state to a mesotrophic state; AZCI also indicated that the environmental quality of the water body was poor. The effects of urban wastewater supply with insufficient treatment resulted in symptoms of eutrophication and loss of ecological functions and services of the coastal ecosystem in La Salada Cove.
THE ATOMIC-TO-MOLECULAR TRANSITION IN GALAXIES. II: H i AND H2 COLUMN DENSITIES

Gas in galactic disks is collected by gravitational instabilities into giant atomic–molecular complexes, but only the inner, molecular parts of these structures are able to collapse to form stars. Determining what controls the ratio of atomic-to-molecular hydrogen in complexes is, therefore, a significant problem in star formation and galactic evolution. In this paper, we use the model of H2 formation, dissociation, and shielding developed in the previous paper in this series to make theoretical predictions for atomic-to-molecular ratios as a function of galactic properties. We find that the molecular fraction in a galaxy is determined primarily by its column density and secondarily by its metallicity, and is to a good approximation independent of the strength of the interstellar radiation field. We show that the column of atomic hydrogen required to shield a molecular region against dissociation is ∼10 M☉ pc−2 at solar metallicity. We compare our model to data from recent surveys of the Milky Way and of nearby galaxies, and show that the both the primary dependence of molecular fraction on column density and the secondary dependence on metallicity that we predict are in good agreement with observed galaxy properties.
We know where you live: privacy characterization of foursquare behavior

In the last few years, the increasing interest in location-based services (LBS) has favored the introduction of geo-referenced information in various Web 2.0 applications, as well as the rise of location-based social networks (LBSN). Foursquare, one of the most popular LBSNs, gives incentives to users who visit (check in) specific places (venues) by means of, for instance, mayorships to frequent visitors. Moreover, users may leave tips at specific venues as well as mark previous tips as done in sign of agreement. Unlike check ins, which are shared only with friends, the lists of mayorships, tips and dones of a user are publicly available to everyone, thus raising concerns about disclosure of the user's movement patterns and interests. We analyze how users explore these publicly available features, and their potential as sources of information leakage. Specifically, we characterize the use of mayorships, tips and dones in Foursquare based on a dataset with around 13 million users. We also analyze whether it is possible to easily infer the home city (state and country) of a user from these publicly available information. Our results indicate that one can easily infer the home city of around 78% of the analyzed users within 50 kilometers.