Miracle-dz/UniFAR-FTUs huggingface dataset:
A Role for Dopamine in Temporal Decision Making and Reward Maximization in Parkinsonism

Converging evidence implicates striatal dopamine (DA) in reinforcement learning, such that DA increases enhance “Go learning” to pursue actions with rewarding outcomes, whereas DA decreases enhance “NoGo learning” to avoid non-rewarding actions. Here we test whether these effects apply to the response time domain. We employ a novel paradigm which requires the adjustment of response times to a single response. Reward probability varies as a function of response time, whereas reward magnitude changes in the opposite direction. In the control condition, these factors exactly cancel, such that the expected value across time is constant (CEV). In two other conditions, expected value increases (IEV) or decreases (DEV), such that reward maximization requires either speeding up (Go learning) or slowing down (NoGo learning) relative to the CEV condition. We tested patients with Parkinson's disease (depleted striatal DA levels) on and off dopaminergic medication, compared with age-matched controls. While medicated, patients were better at speeding up in the DEV relative to CEV conditions. Conversely, nonmedicated patients were better at slowing down to maximize reward in the IEV condition. These effects of DA manipulation on cumulative Go/NoGo response time adaptation were captured with our a priori computational model of the basal ganglia, previously applied only to forced-choice tasks. There were also robust trial-to-trial changes in response time, but these single trial adaptations were not affected by disease or medication and are posited to rely on extrastriatal, possibly prefrontal, structures.
Insular volume abnormalities associated with different transition probabilities to psychosis

Background Although individuals vulnerable to psychosis show brain volumetric abnormalities, structural alterations underlying different probabilities for later transition are unknown. The present study addresses this issue by means of voxel-based morphometry (VBM). Method We investigated grey matter volume (GMV) abnormalities by comparing four neuroleptic-free groups: individuals with first episode of psychosis (FEP) and with at-risk mental state (ARMS), with either long-term (ARMS-LT) or short-term ARMS (ARMS-ST), compared to the healthy control (HC) group. Using three-dimensional (3D) magnetic resonance imaging (MRI), we examined 16 FEP, 31 ARMS, clinically followed up for on average 3 months (ARMS-ST, n=18) and 4.5 years (ARMS-LT, n=13), and 19 HC. Results The ARMS-ST group showed less GMV in the right and left insula compared to the ARMS-LT (Cohen's d 1.67) and FEP groups (Cohen's d 1.81) respectively. These GMV differences were correlated positively with global functioning in the whole ARMS group. Insular alterations were associated with negative symptomatology in the whole ARMS group, and also with hallucinations in the ARMS-ST and ARMS-LT subgroups. We found a significant effect of previous antipsychotic medication use on GMV abnormalities in the FEP group. Conclusions GMV abnormalities in subjects at high clinical risk for psychosis are associated with negative and positive psychotic symptoms, and global functioning. Alterations in the right insula are associated with a higher risk for transition to psychosis, and thus may be related to different transition probabilities.
Antisense therapy targeting MDM2 oncogene in prostate cancer: Effects on proliferation, apoptosis, multiple gene expression, and chemotherapy

This study was undertaken to investigate the role of mouse double minute 2 (MDM2) oncogene in prostate cancer growth and the potential of MDM2 as a target for prostate cancer therapy. An antisense anti-human–MDM2 mixed-backbone oligonucleotide was tested in human prostate cancer models with various p53 statuses, LNCaP (p53wt/wt), DU145 (p53mt/mt), and PC3 (p53null). In a dose- and time-dependent manner, it specifically inhibited MDM2 expression and modified expression of several genes, at both mRNA and protein levels. In LNCaP cells, p53, p21, Bax, and hypophosphorylated retinoblastoma tumor suppressor protein (pRb) levels increased, whereas Bcl2, pRb protein, and E2F transcription factor 1 (E2F1) levels decreased. In DU145 cells, p21 levels were elevated and E2F1 levels decreased, although mutant p53, Rb, and Bax levels remained unchanged. In PC3 cells, MDM2 inhibition resulted in elevated p21, Bax, and pRb levels and decreased ppRb and E2F1 levels. In all three cell lines, MDM2 inhibition reduced cell proliferation, induced apoptosis, and potentiated the effects of the chemotherapeutic agents 10-hydroxycamptothecin and paclitaxel. The anti-MDM2 oligonucleotide showed antitumor activity and increased therapeutic effectiveness of paclitaxel in both LNCaP and PC3 xenografts, causing changes in gene expression similar to those seen in vitro. In summary, this study demonstrates that MDM2 has a role in prostate cancer growth via p53-dependent and p53-independent mechanisms and that multiple genes are involved in the process. MDM2 inhibitors such as second-generation antisense oligonucleotides have a broad spectrum of antitumor activities in human cancers regardless of p53 status, providing novel approaches to therapy of human prostate cancer.
PowerBlade: A Low-Profile, True-Power, Plug-Through Energy Meter

We present PowerBlade, the smallest, lowest cost, and lowest power AC plug-load meter that measures real, reactive and apparent power, and reports this data, along with cumulative energy consumption, over an industry-standard Bluetooth Low Energy radio. Achieving this design point requires revisiting every aspect of conventional power meters: a new method of acquiring voltage; a non-invasive, planar method of current measurement; an efficient and accurate method of computing power from the voltage and current channels; a radio interface that leverages nearby smart phones to display data and report it to the cloud; and a retro power supply re-imagined with vastly lower current draw, allowing extreme miniaturization. PowerBlade occupies a mere 1" × 1" footprint, offers a 1/16" profile, draws less than 180 mW itself, offers 1.13% error on unity power factor loads in the 2-1200 W range and slightly worse for non-linear and reactive loads, and costs $11 in modest quantities of about 1,000 units. This new design point enables affordable large-scale studies of plug-load energy usage--an area of growing national importance.
A simple bandwidth management strategy based on measurements of instantaneous virtual path utilization in ATM networks

A new connection admission control method based on actual virtual path traffic measurements is proposed to achieve high bandwidth efficiency for various types of traffic. The proposed method is based on the measurement of instantaneous virtual path utilization, which is defined as the total cell rate of the active virtual channels normalized by the virtual path capacity. A low-pass filter is used to determine the instantaneous virtual path utilization from crude measurements. A smoothing coefficient formula is derived as a function of the peak rate of the virtual channel. The residual bandwidth is derived from the maximum instantaneous utilization observed during a monitoring period. Simulation shows that the proposed method achieves statistical multiplexing gains of up to 80% of the limit possible with optimum control for similar traffic sources. It can be implemented with very simple hardware. The admission decision is simple: the requested bandwidth is compared with the residual bandwidth. This method is therefore well suited for practical asynchronous transfer mode switching systems.
Simultaneous Recovery of RNA and DNA from Soils and Sediments

ABSTRACT Recovery of mRNA from environmental samples for measurement of in situ metabolic activities is a significant challenge. A robust, simple, rapid, and effective method was developed for simultaneous recovery of both RNA and DNA from soils of diverse composition by adapting our previous grinding-based cell lysis method (Zhou et al., Appl. Environ. Microbiol. 62:316–322, 1996) for DNA extraction. One of the key differences is that the samples are ground in a denaturing solution at a temperature below 0°C to inactivate nuclease activity. Two different methods were evaluated for separating RNA from DNA. Among the methods examined for RNA purification, anion exchange resin gave the best results in terms of RNA integrity, yield, and purity. With the optimized protocol, intact RNA and high-molecular-weight DNA were simultaneously recovered from 19 soil and stream sediment samples of diverse composition. The RNA yield from these samples ranged from 1.4 to 56 μg g of soil−1 dry weight), whereas the DNA yield ranged from 23 to 435 μg g−1. In addition, studies with the same soil sample showed that the DNA yield was, on average, 40% higher than that in our previous procedure and 68% higher than that in a commercial bead milling method. For the majority of the samples, the DNA and RNA recovered were of sufficient purity for nuclease digestion, microarray hybridization, and PCR or reverse transcription-PCR amplification.
Recanalization with Stent-Retriever Devices in Patients with Wake-Up Stroke

BACKGROUND AND PURPOSE: Stent-retriever devices play an increasing role in the interventional treatment of acute stroke patients, because fast recanalization can be achieved. The purpose of this study was to evaluate the feasibility of stent-retriever recanalization in patients with wake-up stroke in the anterior circulation. MATERIALS AND METHODS: We retrospectively analyzed clinical and angiographic data of 19 consecutive patients with wake-up stroke who were treated with stent-retriever devices between 2009 and October 2011. Recanalization was assessed by using the Thrombolysis in Cerebral Infarction score. Clinical outcome was evaluated at discharge and after 90 days by using the modified Rankin Scale. RESULTS: Median NIHSS score at admission was 17 (IQR, 15–20). Before the procedure, the TICI score was 0 in 18 patients and 1 in 1 patient. Recanalization with stent-retriever devices was successful (TICI ≥ 2) in 94.7%. Mean time to flow restoration was 36.7 minutes and to complete recanalization 83.7 minutes. Symptomatic intracranial hemorrhage occurred in 4 patients (21.1%). Eight patients had an NIHSS improvement of ≥4 points between admission and discharge. After 90 days, 2 (10.5%) of our patients presented with mRS 0–2; seven (36.8%) died. CONCLUSIONS: Despite successful and rapid recanalization with stent-retriever devices, good clinical outcome in patients with wake-up stroke is achieved in a minority of patients. Clinical outcome remains poor. Bleeding rates were higher compared with recanalization procedures within 6 hours after stroke onset.
Effectiveness of occlusive bedding in the treatment of atopic dermatitis – a placebo‐controlled trial of 12 months' duration

Background: Several studies on avoidance of house‐dust‐mite (HDM) and cat allergens have been carried out, most of them in asthmatic patients and only a few in patients with atopic dermatitis (AD). No study so far has focused on which subgroup of AD patients benefits from avoidance measures.
Internalising agents in CSP protocol models ( Extended

We carry forward the work described in our previous papers [2, 11, 9] on the application of data independence to the model checking of cryptographic protocols using CSP [10] and FDR [4], often via extensions to Casper [5]. Since FDR can only check a finite instance of a problem it was originally only possible to check small instances of security protocols (only involving a few agents and runs). This was excellent for finding attacks, but unsatisfactory as a method of proof of correctness. There has been work on getting round this limitation in a variety of related approaches to protocol modelling, for example [6, 8, 12]. In our previous papers we showed how techniques based on data independence [3, 10] (where programs treat certain types simply and can be viewed as having these types as parameters) could be used to justify, by means of a single finite FDR check, systems in which the number of agents was unbounded and in which each could undertake an unbounded number of runs of the protocol. Most of this work was devoted to showing how a finite type could give the illusion (in a way guaranteed to preserve any attack) of being infinite by a careful process of on-the-fly mapping of values of this type (which might be nonces or keys) once they have been forgotten by trustworthy processes (i.e., become stale). Since the necessary CSP codings of security protocols, having been rather complex prior to this work, became far worse with these mappings implemented, their creation was automated in Casper. Aside from restrictions necessary to make our results work (see below), and assumptions common across the whole field arising from the symbolic representation of cryptographic primitives, there was one significant incompleteness in the results we obtained. This was that, while each individual identity could perform an unlimited number of protocol runs, it usually had to do them in sequence. (For small protocols it was possible to run two parallel instances of an agent, but even that was of course far from unbounded! ) We now report significant progress towards the solution of this problem, by means anticipated in [2], namely by “internalising” all or part of each agent identity within the “intruder” process. The internalisation of agents (initially only server roles) was introduced in [11] as a state-space reduction technique (for which it was usually spectacularly successful). It was quickly noticed that this had the beneficial side-effect of making the internalised server arbitrarily parallel, at least in cases where it did not generate any new values of data independent type. But there
Depth map coding with distortion estimation of rendered view

New data formats that include both video and the corresponding depth maps, such as multiview plus depth (MVD), enable new video applications in which intermediate video views (virtual views) can be generated using the transmitted/stored video views (reference views) and the corresponding depth maps as inputs. We propose a depth map coding method based on a new distortion measurement by deriving relationships between distortions in coded depth map and rendered view. In our experiments we use a codec based on H.264/AVC tools, where the rate-distortion (RD) optimization for depth encoding makes use of the new distortion metric. Our experimental results show the efficiency of the proposed method, with coding gains of up to 1.6 dB in interpolated frame quality as compared to encoding the depth maps using the same coding tools but applying RD optimization based on conventional distortion metrics.
Henipavirus Infection in Fruit Bats (Pteropus giganteus), India

We tested 41 bats for antibodies against Nipah and Hendra viruses to determine whether henipaviruses circulate in pteropid fruit bats (Pteropus giganteus) in northern India. Twenty bats were seropositive for Nipah virus, which suggests circulation in this species, thereby extending the known distribution of henipaviruses in Asia westward by >1,000 km.
Experience with spinal injuries in New South Wales.

Two hundred and two patients with acute and severe spinal injuries were treated in various hospitals in New South Wales during 1977 and 1978. Of these, 132 (65%) were cervical, 60 (30%) thoracic, eight (4%) lumbar and two were inadequately recorded. A major concurrent injury to the head was present in every third patient, to the chest in every fourth patient, and to the limbs in every fifth patient. The outcomes of patients reported in this series make it one of the worst in the literature. Sixty-nine (34%) patients died in hospital; of the 133 survivors, only 22 (11%) have resumed work, the remainder being partially or totally disabled. It is estimated that another 302 patients died before arrival in hospital. In country areas, the time lags between accident and ambulance notification, and between notification and arrival at hospital, were uncertain in many cases, but periods in excess of 2 hours were recorded in 28 (14%). One-man ambulances or private vehicles were used in at least 43 cases (21%). After admission, 139 patients were transferred to other hospitals for definitive treatment, arriving after an average time of 22 h (median time 9 h); for such patients, the original hospital presumably served as a first aid station. A case control study suggests that preventable delay in transport, inappropriate treatment, and failure to correct shock may have been causative factors in 16 deaths in this series. Reduction of the time lag between accident and institution of definitive treatment will save lives, and may avoid some crippling neurological deficits. (ABSTRACT TRUNCATED AT 250 WORDS)
Chinese Text Zero-Watermark Based on Sentence's Entropy

In order to promote the Chinese digital text's copyright protection technology, this paper proposes a Chinese Text Zero-Watermark scenario based on Sentence's Entropy. This scenario calculates the entropies of sentences based on wordfrequency and makes crucial sentence selection based on entropy. After that, watermark is constructed with the order of crucial sentences. Furthermore, to prove its effectiveness, the scenario is validated by simulation and it has shown fine robust and ability of anti-attack.
Tumor Cell Heterogeneity in Small Cell Lung Cancer (SCLC): Phenotypical and Functional Differences Associated with Epithelial-Mesenchymal Transition (EMT) and DNA Methylation Changes

Small Cell Lung Cancer (SCLC) is a specific subtype of lung cancer presenting as highly metastatic disease with extremely poor prognosis. Despite responding initially well to chemo- or radiotherapy, SCLC almost invariably relapses and develops resistance to chemotherapy. This is suspected to be related to tumor cell subpopulations with different characteristics resembling stem cells. Epithelial-Mesenchymal Transition (EMT) is known to play a key role in metastatic processes and in developing drug resistance. This is also true for NSCLC, but there is very little information on EMT processes in SCLC so far. SCLC, in contrast to NSCLC cell lines, grow mainly in floating cell clusters and a minor part as adherent cells. We compared these morphologically different subpopulations of SCLC cell lines for EMT and epigenetic features, detecting significant differences in the adherent subpopulations with high levels of mesenchymal markers such as Vimentin and Fibronectin and very low levels of epithelial markers like E-cadherin and Zona Occludens 1. In addition, expression of EMT-related transcription factors such as Snail/Snai1, Slug/Snai2, and Zeb1, DNA methylation patterns of the EMT hallmark genes, functional responses like migration, invasion, matrix metalloproteases secretion, and resistance to chemotherapeutic drug treatment all differed significantly between the sublines. This phenotypic variability might reflect tumor cell heterogeneity and EMT during metastasis in vivo, accompanied by the development of refractory disease in relapse. We propose that epigenetic regulation plays a key role during phenotypical and functional changes in tumor cells and might therefore provide new treatment options for SCLC patients.
Diagnosis and management of cerebral venous thrombosis

ABSTRACT Cerebral venous thrombosis (CVT) is rare and accounts for 0.5% of all strokes. Its clinical presentation is variable and diagnosis requires a high index of clinical suspicion in conjunction with neuroradiological diagnostic support. Treatment options are limited and are mostly based on consensus. Therefore, familiarity with international guidelines is important. Outcome is often good and most patients make a full recovery, although a small proportion suffers death or disability. Here, we describe the clinical features, risk factors, acute imaging features, management and complications of CVT.
Application Of Papoulis-Gerchberg Method In Image Super-Resolution and Inpainting

In this paper, we study the Papoulis–Gerchberg (PG) method and its applications to domains of image restoration such as super-resolution (SR) and inpainting. We show that the method performs well under certain conditions. We then suggest improvements to the method to achieve better SR and inpainting results. The modification applied to the SR process also allows us to apply the method to a larger class of images by doing away with some of the restrictions inherent in the classical PG method. We also present results to demonstrate the performance of the proposed techniques.
Thromboembolism or atherothromboembolism in atrial fibrillation?

Atrial fibrillation (AF) is associated with increased morbidity, mortality, and ischemic stroke,1 and these ischemic strokes are almost always severe.2 Thrombus formation in the left atrium with ensuing embolism in the cerebral circulation is deemed to be the cause.2 Article see p 1168 According to the Virchow’s triad, hypercoagulability, endothelial dysfunction, and venous stasis should be prerequisite for thrombus formation in the left atrium.3 Several markers of clotting and platelet activation have been detected in AF patients, including high-plasma levels of the prothrombin fragment F1+2, a marker of thrombin generation, and P-selectin, a marker of clotting activation.3 The existence of a prothrombotic state may predispose to vascular disease. In a prospective study performed in 231 AF patients, we showed that plasma levels of CD40L, a marker of platelet activation, was associated with and predicted vascular outcomes, such as ischemic stroke and myocardial infarction (MI), during a follow-up period of 2 years.4 Endothelial dysfunction has been documented by measuring von Willebrand factor, which has been found to be elevated in AF patients and associated with poor vascular outcomes.5 The rate of endothelial damage seems temporarily related to AF duration because the highest levels have been observed in patients with permanent compared with those with paroxysmal or persistent AF.5 Venous stasis is the third component; it is supposed to be related not only to arrhythmia but also to AF-induced atrium remodeling, which could further lower contractility via several mechanisms, including low Ca2+ mobilization and impaired myosin phosphorylation.3 Furthermore, AF-related remodeling of left atrium may have a negative impact on the cardiac circulation as it is associated with downregulation of atrial NO, a molecule with vasodilator and antiaggregating properties.6 It is still unclear, however, whether remodeling-related venous stasis per se is actually …
Creoles at the intersection of variable processes: -t,d deletion and past-marking in the Jamaican mesolect

ABSTRACT -t,d deletion is a well-known variable phonological process subject to the influence of both external social factors and internal structural constraints, including phonetic environmental and morphosyntactic effects. Its profile of variation has been widely investigated in American English dialects. However, it interacts with another grammatical process – the regular affixation of final /-t, -d/ as a past-tense marker – that strongly distinguishes these dialects from English-related creoles, where past-marking by this mechanism is infrequent or non-occurrent. Investigation of -t,d deletion in mesolectal Jamaican Creole (JC) thus raises important questions about the intersection of variable processes, the generality of phonetic environmental constraints, and the degree of difference between English-related creoles and metropolitan standard and non-standard Englishes.