Miracle-dz/UniFAR-FTUs huggingface dataset:
"Girls cannot think as boys do": socialising children through the Zimbabwean school system.

What little attention donor-sponsored research on gender and education in Zimbabwe has paid to how schools educate children to assume gender roles has focused on the effect of girls, but it is equally important for development purposes to deconstruct masculinity and the ability of Western stereotypes to foster patriarchy. In Zimbabwe, the school curriculum continues to be gender-differentiated and, when offered a choice, girls and boys choose subjects that fall within the traditional male/female split, which is promoted by teachers, parents, and peers. In addition, males dominate positions of authority in the secondary school system, and teachers of both sexes consider it their duty to steer pupils towards "gender appropriate" behavior. School textbooks further this stereotyping. Interviews in 1995 with 15 secondary school boys at each of six schools sought to uncover attitudes about gender and education. Most boys (77.5%) reported that it is equally important to educate girls and boys, but only 50.6% believed that girls are as intelligent as boys (while differentiating between the type of intelligence possessed by girls with that enjoyed by boys). The boys also gender-typed school subjects on the basis of perceived differentials in abilities and because they are prerequisites for gender-differentiated occupations. Almost 90% of the boys reported that a wife should obey her husband. Thus, patriarchal values are internalized in schools in a way that will impede development.
The recurrent nevus phenomenon: a history of challenge, controversy, and discovery.

CONTEXT The diagnosis of recurrent nevus poses a potential challenge to practicing pathologists. Although most recurrent nevi show uniform microscopic findings and pose no great diagnostic difficulty, a few cases exhibit some histopathologic features similar to, and in some cases indistinguishable from, melanoma. Historically, the term pseudomelanoma has been used in the literature to describe such recurrent nevi, although this label has the potential for confusion and is no longer the favored term for recurrent pigmented melanocytic nevi. OBJECTIVE To describe historical, histopathologic, and immunohistochemical features of recurrent pigmented melanocytic nevi and to review briefly the literature surrounding the mechanism of recurrence. DATA SOURCES Published peer-reviewed literature and the authors' personal experience. CONCLUSIONS Recognition of the histopathologic pattern of recurrent nevi leads the pathologist to the correct diagnosis in most cases; however, in particularly challenging specimens or in circumstances in which there is insufficient clinical history, immunohistochemical studies have proved helpful in distinguishing recurrent nevi from melanoma.
Acupuncture, a promising adjunctive therapy for essential hypertension: a double-blind, randomized, controlled trial

Abstract Background: This study assessed effects of acupuncture as an add-on to conventional antihypertensive managements such as medication or lifestyle modification for hypertensive or pre-hypertensive subjects. Methods: A randomized, double-blind, placebo-controlled trial was conducted at Kyung Hee University Hospital. Forty-one hypertensive or pre-hypertensive (systolic BP≥120 mmHg or diastolic BP≥80 mmHg) volunteers were recruited and randomly assigned into real or sham acupuncture groups. The hypertensive subjects on antihypertensive medication continued their medication. Acupuncture point prescriptions were partially individualized, based on the Saam acupuncture theory. Park's sham needle method was adopted for the sham procedure. Measurements were performed at baseline, weeks 4 and 8. BP, scales of overall health and pain, and anticipation or satisfaction for the treatments, were recorded. Results: Thirty subjects completed the intervention, all of whom were on antihypertensive medication. The sham acupuncture group showed no significant change in mean BP, while the real acupuncture group showed a significant (p<0.01) decrease in mean BP after 8 weeks of intervention from 136.8/83.7 to 122.1/76.8 mmHg. Other factors showed no difference between the groups throughout the study. Conclusion: Acupuncture seems to offer an additional benefit to the treatment of hypertensive patients.
Taking Dogs Into the Office: A Novel Strategy for Promoting Work Engagement, Commitment and Quality of Life

Despite growing interest in “take your dog to work” days and the wellbeing benefits associated with interactions with a friendly dog (e.g., animal-assisted activities), there has been little quantification of the benefits of this. We analyzed responses to work-related (work engagement, turnover intention, work-based friendship acuity, social media use, and work-related quality of life) and dog-related (pet dog attachment and dog general health) scales from 749 employees. The predominantly female sample was comprised of 243 employees who brought their dog to work (167 = “often” brought dog to work; 76 = “sometimes” brought dog to work), the remaining 506 did not bring their dog to work. Employees who “often” took their dog to work reported higher than average work engagement on all factors (vigor, dedication, absorption, total), with significant differences reported in comparison to those who “sometimes” (vigor and total) and “never” (vigor, dedication, absorption, total) took their dog to work. Turnover intention was also significantly lower and work-based friendship acuity higher in the group of employees who “often,” compared to “never,” took their dog to work. Benefits of bringing your dog to work were also observed in terms of work-related quality of life, with higher scores on general wellbeing, home-work interface, job career-satisfaction, control at work, working conditions, and overall work quality of life in those who “often” compared to “never” take their dog to work. Employees who “never” took their dog to work reported lower use of social media during break times. We also identified factors which may be important to consider in developing dogs-in-the-workplace policies; dog-demographics including weight (i.e., size), breed-type, and training may be important to consider in defining the ideal office dog and deserve further research. Given the need to improve employee wellbeing and satisfaction to promote effective business performance and economic gain, these results have important implications for office based businesses considering allowing dogs in the workplace.
A conceptual framework for assessing electronic banking continued use

The development and advancement of electronic banking (e-banking) had raised the level competitiveness in the market for financial products and services. More and more banks and other financial institutions adopted such technology to improve service quality and enhance customer satisfaction and loyalty. Despite the increasing number e-banking users globally, little is known on how this technology can help banks to retain customers. Furthermore, it is only recently that researchers have started to understand the importance of consumers' continued use. Therefore, it is the aim of this paper to propose a framework based on an extensive review of current literature in related areas of e-banking domain and continued use. The main benefits of the proposed framework are towards understanding factors that may influence the e-banking continuance usage.
Decreased FOXJ1 expression and its ciliogenesis programme in aggressive ependymoma and choroid plexus tumours

Well‐differentiated human cancers share transcriptional programmes with the normal tissue counterparts from which they arise. These programmes broadly influence cell behaviour and function and are integral modulators of malignancy. Here, we show that the master regulator of motile ciliogenesis, FOXJ1, is highly expressed in cells along the ventricular surface of the human brain. Strong expression is present in cells of the ependyma and the choroid plexus as well as in a subset of cells residing in the subventricular zone. Expression of FOXJ1 and its transcriptional programme is maintained in many well‐differentiated human tumours that arise along the ventricle, including low‐grade ependymal tumours and choroid plexus papillomas. Anaplastic ependymomas as well as choroid plexus carcinomas show decreased FOXJ1 expression and its associated ciliogenesis programme genes. In ependymomas and choroid plexus tumours, reduced expression of FOXJ1 and its ciliogenesis programme are markers of poor outcome and are therefore useful biomarkers for assessing these tumours. Transitions in ciliogenesis define distinct differentiation states in ependymal and choroid plexus tumours with important implications for patient care. Copyright © 2015 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Growth of elaborate microbial pinnacles in Lake Vanda, Antarctica

Microbial pinnacles in ice‐covered Lake Vanda, McMurdo Dry Valleys, Antarctica, extend from the base of the ice to more than 50 m water depth. The distribution of microbial communities, their photosynthetic potential, and pinnacle morphology affects the local accumulation of biomass, which in turn shapes pinnacle morphology. This feedback, plus environmental stability, promotes the growth of elaborate microbial structures. In Lake Vanda, all mats sampled from greater than 10 m water depth contained pinnacles with a gradation in size from <1‐mm‐tall tufts to pinnacles that were centimeters tall. Small pinnacles were cuspate, whereas larger ones had variable morphology. The largest pinnacles were up to ~30 cm tall and had cylindrical bases and cuspate tops. Pinnacle biomass was dominated by cyanobacteria from the morphological and genomic groups Leptolyngbya, Phormidium, and Tychonema. The photosynthetic potential of these cyanobacterial communities was high to depths of several millimeters into the mat based on PAM fluorometry, and sufficient light for photosynthesis penetrated ~5 mm into pinnacles. The distribution of photosynthetic potential and its correlation to pinnacle morphology suggests a working model for pinnacle growth. First, small tufts initiate from random irregularities in prostrate mat. Some tufts grow into pinnacles over the course of ~3 years. As pinnacles increase in size and age, their interiors become colonized by a more diverse community of cyanobacteria with high photosynthetic potential. Biomass accumulation within this subsurface community causes pinnacles to swell, expanding laminae thickness and creating distinctive cylindrical bases and cuspate tops. This change in shape suggests that pinnacle morphology emerges from a specific distribution of biomass accumulation that depends on multiple microbial communities fixing carbon in different parts of pinnacles. Similarly, complex patterns of biomass accumulation may be reflected in the morphology of elaborate ancient stromatolites.
The Finding of Premalignant Lesions is Not Associated with Smoking Cessation in Chemoprevention Study Volunteers

Background and Study Aims: Screening programs for lung cancer may lead to a heightened awareness of the risks of smoking and enhance quitting. The aim of this study was to evaluate whether the participation on a chemoprevention study for premalignant lesions could influence smoking cessation. Methods: Two hundred one volunteers, current (n = 188) and former smokers (n = 13) with more than 20 pack years had been screened for the chemoprevention study. One hundred forty-six of the current smokers at time of chemoprevention study screening have been retrospectively interviewed about their smoking behavior ≥1 year after their first contact for the chemoprevention study. Structured questionnaires were used, and interviews were held by telephone. The quitters at the time of these first interviews were contacted again 4 years after the initial interview about their current smoking behavior. Results: Of the 146 smoking volunteers, 83 were diagnosed with premalignant lesions of the bronchial mucosa and participated in the chemoprevention study, and 63 had no premalignant lesions and were not included in that study. The majority of participants were men: 87 (60%). The mean age of the participants was 52 ± 9 years, and the mean age at which volunteers started smoking was 15 ± 3. Mean number of pack years was 47 ± 27. Ten volunteers in the group without premalignant lesions and 19 in the group with premalignant lesions had quit smoking at time of the first interview. The smoking cessation rate of the total study group was 20%. Univariate logistic regression analysis demonstrated that smoking cessation was only significantly associated with male gender. No significant associations were found between smoking cessation and the finding of premalignant lesions, sex, age, level of addiction, educational level, marital condition, history of cancer/pulmonary diseases, age at start smoking, previous attempts to quit smoking, and motivation to quit smoking. Within the group of subjects who had quit smoking at the time of the first interview, 15 of 29 persons who had stopped smoking at the time of the first interview have reported that participation in the bronchoscopy screening and/or the trial has been of major influence on their decision to stop smoking. Conclusions: A smoking cessation rate of 20% has been found among volunteers for a chemopreventive trial investigating smoking-related premalignant lesions after almost 2 years after initial contact has been found. Volunteers experienced screening and trial participation as having influenced their smoking cessation. Smoking cessation was significantly associated with male gender, whereas the finding of premalignant lesions by bronchoscopy was not.
Dynamic message-passing equations for models with unidirectional dynamics

Understanding and quantifying the dynamics of disordered out-of-equilibrium models is an important problem in many branches of science. Using the dynamic cavity method on time trajectories, we construct a general procedure for deriving the dynamic message-passing equations for a large class of models with unidirectional dynamics, which includes the zero-temperature random-field Ising model, the susceptible-infected-recovered model, and rumor spreading models. We show that unidirectionality of the dynamics is the key ingredient that makes the problem solvable. These equations are applicable to single instances of the corresponding problems with arbitrary initial conditions and are asymptotically exact for problems defined on locally treelike graphs. When applied to real-world networks, they generically provide a good analytic approximation of the real dynamics.
The Poisson Channel With Varying Dark Current Known to the Transmitter

This paper studies the continuous-time Poisson channel whose dark current is random and may change for every <inline-formula> <tex-math notation="LaTeX">$\tau $ </tex-math></inline-formula>-second time interval, where the actual values of the dark current are known to the transmitter as channel-state information (CSI). In the limit where <inline-formula> <tex-math notation="LaTeX">$\tau $ </tex-math></inline-formula> tends to zero, the capacity gain provided by both causal and noncausal CSI is shown to vanish linearly with <inline-formula> <tex-math notation="LaTeX">$\tau $ </tex-math></inline-formula>, so CSI at the transmitter provides almost no capacity improvement. The paper also considers a related problem of the state-dependent very noisy channel. In the very noisy limit, the capacity gain provided by noncausal CSI is shown to be the same as that provided by causal CSI.
Automated Classification of Circulating Tumor Cells and the Impact of Interobsever Variability on Classifier Training and Performance

Application of personalized medicine requires integration of different data to determine each patient's unique clinical constitution. The automated analysis of medical data is a growing field where different machine learning techniques are used to minimize the time-consuming task of manual analysis. The evaluation, and often training, of automated classifiers requires manually labelled data as ground truth. In many cases such labelling is not perfect, either because of the data being ambiguous even for a trained expert or because of mistakes. Here we investigated the interobserver variability of image data comprising fluorescently stained circulating tumor cells and its effect on the performance of two automated classifiers, a random forest and a support vector machine. We found that uncertainty in annotation between observers limited the performance of the automated classifiers, especially when it was included in the test set on which classifier performance was measured. The random forest classifier turned out to be resilient to uncertainty in the training data while the support vector machine's performance is highly dependent on the amount of uncertainty in the training data. We finally introduced the consensus data set as a possible solution for evaluation of automated classifiers that minimizes the penalty of interobserver variability.
Open Pancreatic Necrosectomy in the Multidisciplinary Management of Postinflammatory Necrosis

Objective:To examine clinical outcome in a consecutive cohort of patients undergoing open necrosectomy for postinflammatory necrosis. Background Information:The last decade has witnessed major developments in the surgical management of pancreatic necrosis. Minimally invasive approaches have become established. However, there are limited data from contemporary open necrosectomy, in particular where multidisciplinary care and aggressive interventional radiology are used. This report provides data on outcome from open necrosectomy in a tertiary referral Hepatobiliary unit over the last decade. Methods:During the period January 1, 2000 to July 31, 2008, 1535 patients were admitted with a final discharge code of acute pancreatitis. Twenty-eight (1.8%) of all admissions underwent open surgical necrosectomy. Twenty-four (86%) were tertiary referral patients. Results:The median APACHE II score on admission was 10.5 (5–26). Median logistic organ dysfunction score on admission was 3 (0–10). Median LODS score after surgery was 2 (0–8). Twenty patients (71%) underwent radiologically guided drainage of collections before surgery. Thirty-day mortality occurred in 2 (7%), 4 further deaths occurred in patients after discharge from intensive care resulting in a total of 6 (22%) episode-related deaths. Conclusions:Modern open necrosectomy can be performed without the procedure-related deterioration in organ dysfunction associated with major debridement. Multidisciplinary care with an emphasis on aggressive radiologic intervention before and after surgery results in acceptable outcomes in this cohort of critically ill patients. Newer laparoscopic techniques must demonstrate similar outcomes in the setting of stage-matched severity before wider acceptance.
Culture-confirmed multidrug-resistant tuberculosis in children: clinical features, treatment, and outcome.

BACKGROUND Multidrug-resistant (MDR) tuberculosis in children is frequently associated with delayed diagnosis and treatment. There is limited evidence regarding the management and outcome of children with MDR-tuberculosis. METHODS All children <15 years of age with a diagnosis of culture-confirmed MDR-tuberculosis were included in this retrospective cohort study from 1 January 2003 to 31 December 2008, with follow-up documented until 31 May 2011. We identified children from Brooklyn Hospital for Chest Diseases and Tygerberg Children's Hospital, Western Cape Province, South Africa. Treatment outcomes were defined as 2-month sputum-culture conversion, treatment episode outcome, and survival. RESULTS A total of 111 children (median age, 50 months) were included. The diagnosis was delayed in children who had no identified MDR-tuberculosis index case (median delay, 123 vs 58 days; P < .001). Sixty-two percent of patients (53 of 85) were sputum-smear positive, and 43% of patients (43 of 100) were human immunodeficiency virus (HIV) infected. Overall, 82% had favorable treatment outcomes; total mortality was 12%. Malnutrition was associated with failure to culture-convert at 2 months (odds ratio [OR], 4.49 [95% confidence interval {CI}, 1.32-15.2]; P = .02) and death (OR, 15.0 [95% CI, 1.17-192.5]; P = .04) in multivariate analysis. HIV coinfection (OR, 24.7 [95% CI, 1.79-341.1]; P = .02) and the presence of extrapulmonary tuberculosis (OR, 37.8 [95% CI, 2.78-513.4]; P = .006) predicted death. CONCLUSIONS Despite advanced disease at presentation and a high prevalence of human immunodeficiency virus coinfection, children with MDR-tuberculosis can be treated successfully, using individualized treatment under routine conditions.
Increased insulin concentrations in nondiabetic offspring of diabetic parents.

Abstract Insulin resistance is thought by many to be the primary defect that results in non-insulin-dependent diabetes mellitus (NIDDM). An implication of this theory is that prediabetic persons have higher serum insulin levels than normal subjects. We assessed serum insulin concentrations in a cohort of 1497 nondiabetic Mexican Americans, a population at high risk for NIDDM, according to whether their parents or siblings had diabetes. It was assumed that prediabetic persons would be more likely to have strong family histories of diabetes. We found a stepwise increase in fasting insulin levels in nondiabetics with neither, one, or both parents with diabetes (69.8, 77.8, and 94.6 pmol per liter, respectively; P = 0.002). Similar results were observed for insulin sum (the total of insulin concentrations in the fasting state and at 30, 60, and 120 minutes after a 75-g oral glucose load). The differences in insulin sums according to family history remained statistically significant in analyses of covariance, .
The Relationship between BMI and Glycated Albumin to Glycated Hemoglobin (GA/A1c) Ratio According to Glucose Tolerance Status

Glycated albumin to glycated hemoglobin (GA/A1c) ratio is known to be inversely related with body mass index (BMI) and insulin secretory capacity. However, the reasons for this association remain unknown. We aimed to investigate whether BMI directly or indirectly influences GA/A1c by exerting effects on insulin secretion or resistance and to confirm whether these associations differ according to glucose tolerance status. We analyzed a total of 807 subjects [242 drug-naïve type 2 diabetes (T2D), 378 prediabetes, and 187 normal glucose tolerance (NGT)]. To assess the direct and indirect effects of BMI on GA/A1c ratio, structural equation modeling (SEM) was performed. GA/A1c ratio was set as a dependent variable, BMI was used as the independent variable, and homeostasis model assessment-pancreatic beta-cell function (HOMA-β), homeostasis model assessment-insulin resistance (HOMA-IR), glucose level were used as mediator variables. The estimates of a direct effect of BMI on GA/A1c to be the strongest in NGT and weakest in T2D (−0.375 in NGT, −0.244 in prediabetes, and −0.189 in T2D). Conversely, the indirect effect of BMI on GA/A1c exerted through HOMA-β and HOMA-IR was not statistically significant in NGT group, but significant in prediabetes and T2D groups (0.089 in prediabetes, −0.003 in T2D). It was found that HOMA-β or HOMA-IR indirectly influences GA/A1c in T2D and prediabetes group through affecting fasting and postprandial glucose level. The relationship between GA/A1c and BMI is due to the direct effect of BMI on GA/A1c in NGT group, while in T2D and prediabetes groups, this association is mostly a result of BMI influencing blood glucose through insulin resistance or secretion.