Miracle-dz/UniFAR-FTUs huggingface dataset:
NeuroImage: Clinical Dorsolateral prefrontal cortex contributes to the impaired behavioral adaptation in alcohol dependence ☆

Substance-dependent individuals often lack the ability to adjust decisions ﬂ exibly in response to the changes in reward contingencies. Prediction errors (PEs) are thought to mediate ﬂ exible decision-making by updating the reward values associated with available actions. In this study, we explored whether the neurobiological correlates of PEs are altered in alcohol dependence. Behavioral, and functional magnetic resonance imaging (fMRI) data were simultaneously acquired from 34 abstinent alcohol-dependent patients (ADP) and 26 healthy controls (HC) during a probabilistic reward-guided decision-making task with dynamically changing reinforcement contingencies. A hierarchical Bayesian inference method was used to ﬁ t and compare learning models with di ﬀ erent assumptions about the amount of task-related information subjects may have inferred during the experiment. Here, we observed that the best- ﬁ tting model was a modi ﬁ ed Rescorla-Wagner type model, the “ double-update ” model, which assumes that subjects infer the knowledge that reward contingencies are anti-correlated, and integrate both actual and hypothetical outcomes into their decisions. Moreover, comparison of the best- ﬁ tting model's parameters showed that ADP were less sensitive to punishments compared to HC. Hence, decisions of ADP after punishments were loosely coupled with the expected reward values assigned to them. A correlation analysis between the model-generated PEs and the fMRI data revealed a reduced association between these PEs and the BOLD activity in the dorsolateral prefrontal cortex (DLPFC) of ADP. A hemispheric asymmetry was observed in the DLPFC when positive and negative PE signals were analyzed separately. The right DLPFC activity in ADP showed a reduced correlation with positive PEs. On the other hand, ADP, particularly the patients with high dependence severity, recruited the left DLPFC to a lesser extent than HC for processing negative PE signals. These results suggest that the DLPFC, which has been linked to adaptive control of action selection, may play an important role in cognitive in ﬂ exibility observed in alcohol dependence when reinforcement contingencies change. Particularly, the left DLPFC may contribute to this impaired behavioral adaptation, possibly by impeding the extinction of the actions that no longer lead to a reward.
Resident macrophages of pancreatic islets have a seminal role in the initiation of autoimmune diabetes of NOD mice

Significance Our studies indicate that the resident macrophages of the pancreatic islets of Langerhans have a seminal role in the initiation and progression of autoimmune diabetes in NOD mice. In this study, islet macrophages were depleted by administration of a monoclonal antibody to the CSF-1 receptor. Macrophage depletion, either at the start of the autoimmune process or when diabetogenesis is active, leads to a significant reduction in diabetes incidence. Depletion of the islet macrophages reduces the entrance of T cells into islets and results in the absence of antigen presentation. Concordantly, a regulatory pathway develops that controls diabetes progression. We conclude that treatments that target the islet macrophages may have important clinical relevance for the control of autoimmune type 1 diabetes. Treatment of C57BL/6 or NOD mice with a monoclonal antibody to the CSF-1 receptor resulted in depletion of the resident macrophages of pancreatic islets of Langerhans that lasted for several weeks. Depletion of macrophages in C57BL/6 mice did not affect multiple parameters of islet function, including glucose response, insulin content, and transcriptional profile. In NOD mice depleted of islet-resident macrophages starting at 3 wk of age, several changes occurred: (i) the early entrance of CD4 T cells and dendritic cells into pancreatic islets was reduced, (ii) presentation of insulin epitopes by dispersed islet cells to T cells was impaired, and (iii) the development of autoimmune diabetes was significantly reduced. Treatment of NOD mice starting at 10 wk of age, when the autoimmune process has progressed, also significantly reduced the incidence of diabetes. Despite the absence of diabetes, NOD mice treated with anti–CSF-1 receptor starting at 3 or 10 wk of age still contained variably elevated leukocytic infiltrates in their islets when examined at 20–40 wk of age. Diabetes occurred in the anti–CSF-1 receptor protected mice after treatment with a blocking antibody directed against PD-1. We conclude that treatment of NOD mice with an antibody against CSF-1 receptor reduced diabetes incidence and led to the development of a regulatory pathway that controlled autoimmune progression.
Ketamine-Propofol vs Ketamine-Dexmedetomidine Combinations in Pediatric Patients Undergoing Burn Dressing Changes

The aim of this study was to compare ketamine-propofol (KP) and ketamine-dexmedetomidine (KD) combinations for deep sedation and analgesia during pediatric burn wound dressing changes. After obtaining approval from the University Ethics Committee, burn wound care or wound dressing changes were performed on 60 American Society of Anesthesiologists physical status I and II inpatients aged between 8 and 60 months with second-degree burns ranging from 5 to 25% TBSA. After recording the demographic data, the heart rate, systolic arterial pressure, diastolic arterial pressure, peripheral oxygen saturation, respiratory rate, and Ramsey sedation scores were recorded for all patients before and during the procedure. Group KP (n = 30) received 1 mg kg−1 ketamine + 1 mg kg−1 propofol and group KD (n = 30) received 1 mg kg−1 ketamine + 0.5 µg kg−1 dexmedetomidine for induction. Additional propofol (1 mg kg−1) for group KP and additional dexmedetomidine (0.5 µg kg−1) for group KD were administered when required. No statistically significant differences in sedation scores and peripheral oxygen saturation and diastolic arterial pressure (P > .05) were found between the two groups. However, systolic blood pressure values in group KD showed a significant increase after induction (P < .05). The recovery time was longer in group KD than in group KP (P < .05). The respiratory rate was higher in group KD than in group KP beginning from the fifth minute of the procedure. A significant amount of respiratory depression and hypoxia was observed in group KP but not in KD (P < .05). Both the KP and KD combinations were effective for sedation and analgesia during dressing changes in the pediatric burn patients. The KD combination can be considered as an excellent alternative for pediatric wound dressing changes which does not result in respiratory depression.
Quasi‐graphic matroids *

Frame matroids and lifted‐graphic matroids are two interesting generalizations of graphic matroids. Here, we introduce a new generalization, quasi‐graphic matroids, that unifies these two existing classes. Unlike frame matroids and lifted‐graphic matroids, it is easy to certify that a 3‐connected matroid is quasi‐graphic. The main result is that every 3‐connected representable quasi‐graphic matroid is either a lifted‐graphic matroid or a frame matroid.
Physical and Mechanical Properties of Three-Layer Particleboard Manufactured from the Tree Pruning of Seven Wood Species

This study was carried out to investigate the feasibility of using tree prunings of seven wood species available in Saudi Arabia to manufacture three-layered resin-bonded particleboard. The wood species used were J. procera as softwood species collected from Al-Baha region, southwest of the kingdom and six hardwood species viz., A. salicina, C. erectus, F. altissima, L. glauca, P. dulce and T. aphylla collected from different sites of Riyadh city during year 2011. Boards were pressed at target density level of 750 kg m and the resin content for core and surfaces was 8 and 10%, 3 respectively based on oven dry weight. The press conditions were 150 °C, 3.5 MPa and 8 min. Mechanical properties in static bending (MOR and MOE), tensile strength perpendicular to board surface (IB) and screw holding power were determined. In addition, water absorption and thickness swelling were also determined after 2 and 24 h water immersion. Chemical constitutents of wood had the highest effects on the properties of the produced particleboard. Results indicated that the suitability of waste material to manufacture high-quality particleboards with high strength and dimensional properties and points to a need of future research along that line. Additional treatments might be needed such as coating surface with melamine-impregnated paper or chemical modification of particles to improve the panel quality especially their dimensional stability.
Initial Investigations into Characterizing DIY E-Textile Stretch Sensors

is paper evaluates three electronic textile (e-textile) stretch sensors commonly constructed for bespoke applications: fabric knit with a stainless steel and polyester yarn, and knit fabric coated with a conductive polymer. Two versions of the knit stainless steel and polyester yarn sensor, one hand and one machine knit, are evaluated. All of the materials used in the construction of the sensors are accessible to designers and engineers, and are commonly used in wearable technology projects, particularly arts performance. However, the properties of each sensor have not before been formally analysed. We evaluate the sensors’ performance when being stretched and released.
Monopoly Innovation and Welfare Effects

Abstract In this paper we study the welfare effect of a monopoly innovation. Unlike many partial equilibrium models carried out in previous studies, general equilibrium models are constructed and analyzed in greater detail. We discover that technical innovation carried out by a monopolist could significantly increase the social welfare. We conclude that, in general, the criticism against monopoly innovation based on its increased deadweight loss is less accurate than previously postulated by many studies.
Mask-streaming CNN for pedestrian detection

Inspired by humans recognition of pedestrians, we propose a mask-streaming convolutional neural network (CNN) for pedestrian detection. The mask stream consists of one original region proposal and six masked regions. These masked regions, which aim at highlighting significantly discriminative semantic characteristic of head, body parts and contextual information, are generated through wiping off a part of the original region by ‘masks’. We feed the mask stream into the network to generate features of each masked region, then a concatenate layer integrates these features as the final representation of pedestrians. We evaluate the proposed model on the challenging Caltech and Eth datasets. Our approach performs better than the baseline, and achieves competitive performance compared to numerous pedestrian detection methods.
The Role of p38 MAPK, JNK, and ERK in Antibacterial Responses of Chilo suppressalis (Lepidoptera: Crambidae)

Abstract The mitogen-activated protein kinases (MAPKs) are conserved signal transduction pathways and broadly responsible for bacterial infection from yeast to mammals, and virus, fungi, and bacteria, specifically Bacillus thuringiensis, to insects. But little is known about the MAPK pathways in antibacterial responses in Chilo suppressalis (Walker), an important lepidopteran pest of rice. In this study, we used the bacteria of Bacillus thuringiensis, Escherichia coli, and Staphyloccocus aureus to infect C. suppressalis larvae, and the responses of MAPK pathways were analyzed. The results showed that E. coli infection induced the up-regulated expression of Csp38 and CsERK1 at 24 h postinfection (pi). Meanwhile, injection of B. thuringiensis and S. aureus resulted in strong activation of CsJNK phosphorylation at 3 h pi. These results suggest that MAPK signaling pathways play important functional roles in antibacterial responses in C. suppressalis larvae.
From Orchestration to Choreography through Contract Automata

We study the relations between a contract automata and an interaction model. In the former model, distributed services are abstracted away as automata - oblivious of their partners - that coordinate with each other through an orchestrator. The interaction model relies on channel-based asynchronous communication and choreography to coordinate distributed services. We define a notion of strong agreement on the contract model, e xhibit a natural mapping from the contract model to the interaction model, and give conditions to ensure that strong agreement corresponds to well-formed choreography.
In-home and remote use of robotic body surrogates by people with profound motor deficits

By controlling robots comparable to the human body, people with profound motor deficits could potentially perform a variety of physical tasks for themselves, improving their quality of life. The extent to which this is achievable has been unclear due to the lack of suitable interfaces by which to control robotic body surrogates and a dearth of studies involving substantial numbers of people with profound motor deficits. We developed a novel, web-based augmented reality interface that enables people with profound motor deficits to remotely control a PR2 mobile manipulator from Willow Garage, which is a human-scale, wheeled robot with two arms. We then conducted two studies to investigate the use of robotic body surrogates. In the first study, 15 novice users with profound motor deficits from across the United States controlled a PR2 in Atlanta, GA to perform a modified Action Research Arm Test (ARAT) and a simulated self-care task. Participants achieved clinically meaningful improvements on the ARAT and 12 of 15 participants (80%) successfully completed the simulated self-care task. Participants agreed that the robotic system was easy to use, was useful, and would provide a meaningful improvement in their lives. In the second study, one expert user with profound motor deficits had free use of a PR2 in his home for seven days. He performed a variety of self-care and household tasks, and also used the robot in novel ways. Taking both studies together, our results suggest that people with profound motor deficits can improve their quality of life using robotic body surrogates, and that they can gain benefit with only low-level robot autonomy and without invasive interfaces. However, methods to reduce the rate of errors and increase operational speed merit further investigation.
Theory of the Compression Hysteresis of Fibrous Assemblies

An analysis of a fibrous assembly at large deformations has been explored as a means of predicting the compressional behavior, especially the compression hysteresis. The essential principle is to classify all the fiber contact points in the assembly as either slipping or nonslipping, so they can be dealt with separately. The compressional modulus and Poisson's ratio are derived and shown to be dominated by the mechanical properties and the directional distribution of the individual fibers within the assembly. An iterative algorithm, in which the system geometry is updated on successive incre ments, is developed to cope with large and nonlinear deformations. A comparison between the theoretical prediction and the experiment has indicated reasonable agree ment. An improvement could probably be achieved by including the contribution of fiber viscoelasticity to the total hysteresis.
Proportional Recovery From Lower Limb Motor Impairment After Stroke

Background and Purpose— In people with preserved corticospinal tract (CST) function after stroke, upper limb impairment resolves by ≈70% within 3 months. This is known as the proportional recovery rule. Patients without CST function do not fit this rule and have worse upper limb outcomes. This study investigated resolution of motor impairment in the lower limb (LL). Methods— Patients with stroke and LL weakness were assessed 3 days and 3 months after stroke with the LL Fugl–Meyer. CST integrity was determined in a subset of patients using transcranial magnetic stimulation to test for LL motor-evoked potentials and magnetic resonance imaging to measure CST lesion load. Linear regression analyses were conducted to predict resolution of motor impairment (&Dgr;Fugl–Meyer) including factors initial impairment, motor-evoked potential status, CST lesion load, and LL therapy dose. Results— Thirty-two patients completed 3-month follow-up and recovered 74% (95% confidence interval, 60%–88%) of initial LL motor impairment. Initial impairment was the only significant predictor of resolution of motor impairment. There was no identifiable cluster of patients who did not fit the proportional recovery rule. Measures of CST integrity did not predict proportional LL recovery. Conclusions— LL impairment resolves by ≈70% within 3 months after stroke. The absence of a nonfitter group may be because of differences in the neuroanatomical organization of descending motor tracts to the upper limb and LL. Proportional recovery of the LL is not influenced by therapy dose providing further evidence that it reflects a fundamental biological process.
Metabolic effects of amino acid mixtures and whey protein in healthy subjects: studies using glucose-equivalent drinks.

BACKGROUND Milk protein, in particular the whey fraction, has been shown to display insulinotrophic properties in healthy persons and persons with type 2 diabetes. In parallel to the hyperinsulinemia, a pronounced postprandial rise of certain amino acids and of glucose-dependent insulinotrophic polypeptide (GIP) was observed in plasma. OBJECTIVE The objective of the study was to determine to what extent the insulinotrophic properties of whey could be simulated by specific amino acid mixtures. DESIGN Twelve healthy volunteers were served drinks consisting of pure glucose (reference drink) or glucose supplemented with free amino acids or whey proteins (test drinks). RESULTS A test drink with the branched-chain amino acids isoleucine, leucine, and valine resulted in significantly higher insulin responses than did the glucose reference. A drink containing glucose and leucine, isoleucine, valine, lysine, and threonine mimicked the glycemic and insulinemic responses seen after whey ingestion. With consumption of this drink, the glucose area under the curve (AUC) was 44% smaller (P < 0.05) and the insulin AUC was 31% larger (NS) than with consumption of the reference drink. With consumption of the whey drink, the AUCs were 56% smaller (glucose; P < 0.05) and 60% larger (insulin; P < 0.05), respectively, than with the reference drink. The whey drink was accompanied by an 80% greater GIP response (P < 0.05), whereas the drinks containing free amino acids did not significantly affect GIP secretion. CONCLUSION A mixture of leucine, isoleucine, valine, lysine, and threonine resulted in glycemic and insulinemic responses closely mimicking those seen after whey ingestion in the absence of an additional effect of GIP and glucagon-like peptide 1.
Differential Radiosensitivity Phenotypes of DNA-PKcs Mutations Affecting NHEJ and HRR Systems following Irradiation with Gamma-Rays or Very Low Fluences of Alpha Particles

We have examined cell-cycle dependence of chromosomal aberration induction and cell killing after high or low dose-rate γ irradiation in cells bearing DNA-PKcs mutations in the S2056 cluster, the T2609 cluster, or the kinase domain. We also compared sister chromatid exchanges (SCE) production by very low fluences of α-particles in DNA-PKcs mutant cells, and in homologous recombination repair (HRR) mutant cells including Rad51C, Rad51D, and Fancg/xrcc9. Generally, chromosomal aberrations and cell killing by γ-rays were similarly affected by mutations in DNA-PKcs, and these mutant cells were more sensitive in G1 than in S/G2 phase. In G1-irradiated DNA-PKcs mutant cells, both chromosome- and chromatid-type breaks and exchanges were in excess than wild-type cells. For cells irradiated in late S/G2 phase, mutant cells showed very high yields of chromatid breaks compared to wild-type cells. Few exchanges were seen in DNA-PKcs-null, Ku80-null, or DNA-PKcs kinase dead mutants, but exchanges in excess were detected in the S2506 or T2609 cluster mutants. SCE induction by very low doses of α-particles is resulted from bystander effects in cells not traversed by α-particles. SCE seen in wild-type cells was completely abolished in Rad51C- or Rad51D-deficient cells, but near normal in Fancg/xrcc9 cells. In marked contrast, very high levels of SCEs were observed in DNA-PKcs-null, DNA-PKcs kinase-dead and Ku80-null mutants. SCE induction was also abolished in T2609 cluster mutant cells, but was only slightly reduced in the S2056 cluster mutant cells. Since both non-homologous end-joining (NHEJ) and HRR systems utilize initial DNA lesions as a substrate, these results suggest the possibility of a competitive interference phenomenon operating between NHEJ and at least the Rad51C/D components of HRR; the level of interaction between damaged DNA and a particular DNA-PK component may determine the level of interaction of such DNA with a relevant HRR component.
Evaluation of targeted exome sequencing for 28 protein‐based blood group systems, including the homologous gene systems, for blood group genotyping

Blood group single nucleotide polymorphism genotyping probes for a limited range of polymorphisms. This study investigated whether massively parallel sequencing (also known as next‐generation sequencing), with a targeted exome strategy, provides an extended blood group genotype and the extent to which massively parallel sequencing correctly genotypes in homologous gene systems, such as RH and MNS.
Parameter estimation for multistage clonal expansion models from cancer incidence data: A practical identifiability analysis

Many cancers are understood to be the product of multiple somatic mutations or other rate-limiting events. Multistage clonal expansion (MSCE) models are a class of continuous-time Markov chain models that capture the multi-hit initiation–promotion–malignant-conversion hypothesis of carcinogenesis. These models have been used broadly to investigate the epidemiology of many cancers, assess the impact of carcinogen exposures on cancer risk, and evaluate the potential impact of cancer prevention and control strategies on cancer rates. Structural identifiability (the analysis of the maximum parametric information available for a model given perfectly measured data) of certain MSCE models has been previously investigated. However, structural identifiability is a theoretical property and does not address the limitations of real data. In this study, we use pancreatic cancer as a case study to examine the practical identifiability of the two-, three-, and four-stage clonal expansion models given age-specific cancer incidence data using a numerical profile-likelihood approach. We demonstrate that, in the case of the three- and four-stage models, several parameters that are theoretically structurally identifiable, are, in practice, unidentifiable. This result means that key parameters such as the intermediate cell mutation rates are not individually identifiable from the data and that estimation of those parameters, even if structurally identifiable, will not be stable. We also show that products of these practically unidentifiable parameters are practically identifiable, and, based on this, we propose new reparameterizations of the model hazards that resolve the parameter estimation problems. Our results highlight the importance of identifiability to the interpretation of model parameter estimates.