Miracle-dz/UniFAR-FTUs huggingface dataset:
Cross-Cultural Similarities and Differences in Person-Body Reasoning: Experimental Evidence From the United Kingdom and Brazilian Amazon

We report the results of a cross-cultural investigation of person-body reasoning in the United Kingdom and northern Brazilian Amazon (Marajó Island). The study provides evidence that directly bears upon divergent theoretical claims in cognitive psychology and anthropology, respectively, on the cognitive origins and cross-cultural incidence of mind-body dualism. In a novel reasoning task, we found that participants across the two sample populations parsed a wide range of capacities similarly in terms of the capacities' perceived anchoring to bodily function. Patterns of reasoning concerning the respective roles of physical and biological properties in sustaining various capacities did vary between sample populations, however. Further, the data challenge prior ad-hoc categorizations in the empirical literature on the developmental origins of and cognitive constraints on psycho-physical reasoning (e.g., in afterlife concepts). We suggest cross-culturally validated categories of "Body Dependent" and "Body Independent" items for future developmental and cross-cultural research in this emerging area.
Fathers Matter

Infant mortality is the most widely used indicator of a nation’s health status and is associated with a plethora of maternal and socioeconomic factors. Although the association between young and old maternal age and the risk of infant mortality is well established, the link between paternal age and birth outcomes has received far less attention. This study seeks to examine the added impact of paternal age on infant mortality, above and beyond that of maternal age among married couples. Using the 2002 linked birth and infant death data set (N = 63,754), hazard odds ratios for the association between combined adolescent and adult maternal and paternal age and the risk of infant mortality were estimated. Maternal demographic characteristics, such as education and race/ethnicity were controlled. The findings indicate that, independent of maternal education and race/ethnicity, adolescent father adds additional risk, above and beyond that of maternal age, only when the mother is older (21-45 years; hazard ratio = 2.7). This study highlights that for married couples, adolescent fathers add to the risk of infant mortality when the mothers are older, providing insight into the role of paternal age in infant mortality. Implications for additional research are discussed.
Patients non-responding to etanercept obtain lower etanercept concentrations compared to responding patients

Objective To investigate the relationship between serum etanercept levels and clinical response. Methods In 292 etanercept-treated patients with rheumatoid arthritis clinical and pharmacological data were determined at baseline and after 1, 4 and 6 months of etanercept treatment. Differences in etanercept levels between good, moderate and European League Against Rheumatism (EULAR) non-responders were assessed after 6 months of therapy. Results After 6 months of therapy etanercept levels were significantly higher in good responders (median (IQR)) 3.78 (2.53-5.17)) compared with both moderate 3.10 (2.12-4.47) and EULAR non-responders 2.80 (1.27-3.93) (all p<0.05). There was a significant association between clinical response and serum etanercept levels (regression coefficient=0.54; 95%CI: 0.21 to 0.86, p=0.001). When patients were categorized into quartiles according to the height of etanercept levels, the lowest quartile (etanercept level <2.1mg/L) comprised 40% of all non-responders. The highest quartile (etanercept level >4.7mg/L) comprised 35% of all EULAR good responders. Anti-etanercept antibodies were detected in none of the sera. Conclusion The authors demonstrated that lower etanercept levels were associated with non-response. Therapeutic drug monitoring and the possibility of the adjusted dosing regimens in the selected groups of patients should be investigated further as a possible tool to optimize treatment with etanercept.
Cholinergic efferent synaptic transmission regulates the maturation of auditory hair cell ribbon synapses

Spontaneous electrical activity generated by developing sensory cells and neurons is crucial for the maturation of neural circuits. The full maturation of mammalian auditory inner hair cells (IHCs) depends on patterns of spontaneous action potentials during a ‘critical period’ of development. The intrinsic spiking activity of IHCs can be modulated by inhibitory input from cholinergic efferent fibres descending from the brainstem, which transiently innervate immature IHCs. However, it remains unknown whether this transient efferent input to developing IHCs is required for their functional maturation. We used a mouse model that lacks the α9-nicotinic acetylcholine receptor subunit (α9nAChR) in IHCs and another lacking synaptotagmin-2 in the efferent terminals to remove or reduce efferent input to IHCs, respectively. We found that the efferent system is required for the developmental linearization of the Ca2+-sensitivity of vesicle fusion at IHC ribbon synapses, without affecting their general cell development. This provides the first direct evidence that the efferent system, by modulating IHC electrical activity, is required for the maturation of the IHC synaptic machinery. The central control of sensory cell development is unique among sensory systems.
Altered Calcium Homeostasis Does Not Explain the Contractile Deficit of Diabetic Cardiomyopathy

OBJECTIVE—This study examines the extent to which the contractile deficit of diabetic cardiomyopathy is due to altered Ca2+ homeostasis. RESEARCH DESIGN AND METHODS—Measurements of isometric force and intracellular calcium ([Ca2+]i, using fura-2/AM) were made in left ventricular (LV) trabeculae from rats with streptozotocin-induced diabetes and age-matched siblings. RESULTS—At 1.5 mmol/l [Ca2+]o, 37°C, and 5-Hz stimulation frequency, peak stress was depressed in diabetic rats (10 ± 1 vs. 17 ± 2 mN/mm2 in controls; P < 0.05) with a slower time to peak stress (77 ± 3 vs. 67 ± 2 ms; P < 0.01) and time to 90% relaxation (76 ± 7 vs. 56 ± 3 ms; P < 0.05). No difference was found between groups for either resting or peak Ca2+, but the Ca2+ transient was slower in time to peak (39 ± 2 vs. 34 ± 1 ms) and decay (time constant, 61 ± 3 vs. 49 ± 3 ms). Diabetic rats had a longer LV action potential (APD50, 98 ± 5 vs. 62 ± 5 ms; P < 0.0001). Western blotting showed that diabetic rats had a reduced expression of sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA)2a, with no difference in expression of the Na+/Ca2+ exchanger. Immunohistochemistry of LV free wall showed that type I collagen was increased in diabetic rats (diabetic 7.1 ± 0.1%, control 12.7 ± 0.1%; P < 0.01), and F-actin content reduced (diabetic 56.9 ± 0.6%; control 61.7 ± 0.4%; P < 0.0001) with a disrupted structure. CONCLUSIONS—We find no evidence to support the idea that altered Ca2+ homeostasis underlies the contractile deficit of diabetic cardiomyopathy. The slower action potential and reduced SERCA2a expression can explain the slower Ca2+ transient kinetics in diabetic rats but not the contractile deficit. Instead, we suggest that the observed LV remodeling may play a crucial role.
Altered matrix production in the distal airways of individuals with asthma

Background and aims Although increasing evidence suggests involvement of the distal airway in all stages of asthma, it is not known whether structural changes (defined as airway remodelling) occur in the distal airways of subjects with mild asthma and those with atopy. The aim of this study was to compare control subjects and those with mild asthma in relation to fibroblast phenotypes and remodelling in central and distal airways. Methods Distal and central fibroblasts from controls (n=12) and patients with mild asthma (n=11) were cultured and incubated for 24 h with 0.4% serum, or stimulated with transforming growth factor β1 (TGFβ1). [35S]Sulfate-labelled proteoglycans in culture medium were analysed by ion exchange chromatography and sodium dodecyl sulfate–polyacrylamide gel electrophoresis. Proliferation was measured with crystal violet, and exhaled nitric oxide was measured by the fractional nitric oxide technique. Results Vesican production from distal fibroblasts was significantly elevated in patients with asthma compared with controls (p<0.001), and the percentage collagen-positive area in distal asthma tissue was also enhanced compared with controls (p<0.01). In addition, distal asthma fibroblasts had reduced proliferation capacity compared with those of controls (by 24%; p<0.01). Furthermore, the alveolar nitric oxide concentration was correlated to distal biglycan and perlecan production of subjects with asthma (r=−0.857, p<0.05 and r=−0.750, p<0.05 respectively) Conclusion It is shown that centrally and distally derived fibroblasts differ in their proteoglycan production and proliferation between central and distal tissue, and in those with asthma compared with controls. It is also demonstrated that remodelling is present in distal lung of subjects with mild asthma. This may be of importance in airway remodelling and asthma progression.
Amantadine treatment is an independent predictor of improved survival in Parkinson's disease

Amantadine has been used for more than 20 years in the symptomatic treatment of Parkinson's disease (PD). Several recent discoveries suggest that amantadine could also have a neuroprotective effect in PD. We studied survival in all parkinsonism (including PD and other parkinsonian syndromes) patients attending a single clinic, employing standard survival curves and a Cox regression model, to identify independent predictive variables for survival (while taking into account factors potentially associated with both outcome and treatment selection). Amantadine-treated patients (n = 250) were similar to the patients not treated with amantadine (n = 586) in terms of age, gender, type of parkinsonism, Hoehn and Yahr stage and dementia status at initial neurological visit. Amantadine use was an independent predictor of improved survival (p < 0.01). Improved survival was also associated with a higher 10-year expected survival (based on age, gender, and birth year), absence of dementia, type of parkinsonism = PD, and low Hoehn and Yahr stage (I or II) at initial neurologic visit (all p < 0.01); these additional factors occurred in statistically similar proportions in the groups that were and were not treated with amantadine. The association of improved survival with amantadine use may stem from symptomatic benefit or may reflect a "neuroprotective'' effect, mediated through N-methyl-D-aspartate (NMDA) receptor antagonism, dopamine uptake blockade activity, or other mechanisms. Our preliminary findings suggest that a prospective, controlled, randomized trial of amantadine's effects on PD progression is warranted. NEUROLOGY 1996;46: 1551-1556
Unexpected Inflammatory Effects of Intravaginal Gels (Universal Placebo Gel and Nonoxynol-9) on the Upper Female Reproductive Tract: A Randomized Crossover Study

Intravaginal anti-HIV microbicides could provide women with a self-controlled means for HIV prevention, but results from clinical trials have been largely disappointing. We postulated that unrecognized effects of intravaginal gels on the upper female reproductive tract might contribute to the lower-than-expected efficacy of HIV microbicides. Our objective was to study the effects of intravaginal gels on the immune microenvironment of the cervix and uterus. In this randomized crossover study, 27 healthy female volunteers used a nightly application of intravaginal nonoxynol-9 (N9) gel as a “failed” microbicide or the universal placebo gel (UPG) as a “safe” gel (intervention cycles), or nothing (control cycle) from the end of menses to the mid-luteal phase. At a specific time-point following ovulation, all participants underwent sample collection for measurements of T-cell phenotypes, gene expression, and cytokine/chemokine protein concentrations from 3 anatomic sites above the vagina: the cervical transformation zone, the endocervix and the endometrium. We used hierarchical statistical models to estimate mean (95% CI) intervention effects, for N9 and UPG relative to control. Exposure to N9 gel and UPG generated a common “harm signal” that included transcriptional up-regulation of inflammatory genes chemokine (C-C motif) ligand 20 (macrophage inflammatory factor-3alpha) and interleukin 8 in the cervix, decreased protein concentrations of secretory leukocyte protease inhibitor, and transcriptional up-regulation of inflammatory mediators glycodelin-A and osteopontin in the endometrium. These results need to be replicated with a larger sample, but underscore the need to consider the effects of microbicide agents and gel excipients on the upper female reproductive tract in studies of vaginal microbicides.
A Passivity-Based Design for Stability and Robustness in Event-Triggered Networked Control Systems with Communication Delays, Signal Quantizations and Packet Dropouts

In this report, we introduce a comprehensive design framework for Event-Triggered Networked Control Systems based on the passivity-based concept of Input Feed-Forward Output Feedback Passive (IF-OFP) systems. Our approach is comprehensive in the sense that we show finite-gain $L_2$-stability and robustness for the networked control system by considering the effects of time-varying or constant network induced delays, signal quantizations, and data losses in communication links from the plant to controller and the controller to plant. Our design is based on the need for a more efficient utilization of band-limited shared communication networks which is a necessity for the design of Large-Scale Cyber-Physical systems. To achieve this, we introduce simple triggering conditions that do not require the exact knowledge of the sub-systems and are located on both sides of the communication network: the plant's output and the controller's output. This specifically leads to a great decrease in the communication rate between the controller and plant. Additionally, we show lower-bounds on inter-event time intervals for the triggering conditions and show the design's robustness against external noise and disturbance. We illustrate the relationship amongst stability, robustness and passivity levels for the plant and controller. We analyze our design's robustness against packet dropouts and loss of communication. Our results are design-oriented in the sense that based on our proposed framework, the designer can easily observe the trade-offs amongst different components of the networked control system, time-varying delays, effects of signal quantizations and triggering conditions, stability, robustness and performance of networked control system and make design decisions accordingly.
Using SVM and error-correcting codes for multiclass dialog act classification in meeting corpus

Accurate classification of dialog acts (DAs) is important for many spoken language applications. Different methods have been proposed such as hidden Markov models (HMM), maximum entropy (Maxent), graphical models, and support vector machines (SVMs). In this paper, we investigate using SVMs for multiclass DA classification in the ICSI meeting corpus. We evaluate (1) representing DA tagging directly as a multiclass task, and (2) combining multiple binary classifiers via error correction output codes (ECOC). For the ECOC combination, different code matrices are utilized (e.g., the identity matrix, exhaustive code, BCH code, and random code matrix). We also compare using SVMs with our previous Maxent model. We find that for DA tagging, using multiple binary SVMs via ECOC outperforms a direct multiclass SVM, but neither achieves better performance than the Maxent model, possibly because of the small class set and the features currently used in the task.
A New Marketing Paradigm for Electronic Commerce

The World Wide Web possesses unique characteristics that distinguish it in important ways from traditional commercial communications environments. Because the Web presents a fundamentally different environment for marketing activities than traditional media, conventional marketing activities are becoming transformed, as they are often difficult to implement in their present form. In this article, we discuss the idea that these changes portend an evolution in the ''marketing concept'' and argue that in order for marketing efforts to be successful in this new medium, a new business paradigm is required. In this new approach, the marketing function must be reconstructed to facilitate electronic commerce in the emerging electronic society underlying the Web.
Measuring Completeness of Building Footprints in OpenStreetMap over Space and Time

Due to financial or administrative constraints, access to official spatial base data is currently limited to a small subset of all potential users in the field of spatial planning and research. This increases the usefulness of Volunteered Geographic Information (VGI), in particular OpenStreetMap (OSM), as supplementary datasets or, in some cases, alternative sources of primary data. In contrast to the OSM street network, which has already been thoroughly investigated and found to be practically complete in many areas, the degree of completeness of OSM data on buildings is still unclear. In this paper we describe methods to analyze building completeness and apply these to various test areas in Germany. Official data from national mapping and cadastral agencies is used as a basis for comparison. The results show that unit-based completeness measurements (e.g., total number or area of buildings) are highly sensitive to disparities in modeling between official data and VGI. Therefore, we recommend object-based methods to study the completeness of OSM building footprint data. An analysis from November 2011 in Germany indicated a completeness of 25% in the federal states of North Rhine-Westphalia and 15% in Saxony. Although further analyses from 2012 confirm that data completeness in Saxony has risen to 23%, the rate of new data input was slowing in the year 2012.
Discrete Logarithm Cryptography

The security of many cryptographic schemes relies on the intractability of the discrete logarithm problem (DLP) in groups. The most commonly used groups to deploy such schemes are the multiplicative (sub)groups of finite fields and (hyper)elliptic curve groups over finite fields. The elements of these groups can be easily represented in a computer and the group arithmetic can be efficiently implemented. In this thesis we first study certain subgroups of characteristic-two and characteristicthree finite field groups, with the goal of obtaining more efficient representation of elements and more efficient arithmetic in the corresponding groups. In particular, we propose new compression techniques and exponentiation algorithms, and discuss some potential benefits and applications. Having mentioned that intractability of DLP is a basis for building cryptographic protocols, one should also take into consideration how a system is implemented. It has been shown that realistic (validation) attacks can be mounted against elliptic curve cryptosystems in the case that group membership testing is omitted. In the second part of the thesis, we extend the notion of validation attacks from elliptic curves to hyperelliptic curves, and show that singular curves can be used effectively in such attacks. Finally, we tackle a specific location-privacy problem called the nearby friend problem. We formalize the security model and then propose a new protocol and its extensions that solve the problem in the proposed security model. An interesting feature of the protocol is that it does not depend on any cryptographic primitive and its security is primarily based on the intractability of the DLP. Our solution provides a new approach to solve the nearby friend problem and compares favorably with the earlier solutions to this problem.
Digestate: A New Nutrient Source - Review

Digestate contains a high proportion of mineral nitrogen (N) especially in the form of ammonium which is available for plants. Moreover, it contains other macroand microelements necessary for plant growth. Therefore the digestate can be a useful source of plant nutrients, it seems to be an effective fertilizer for crop plants. On the other hand, the organic fractions of digestate can contribute to soil organic matter (SOM) turnover, influencing the biological, chemical and physical soil characteristics as a soil amendment.
Systematic review and meta-analysis of the prognostic value of preoperative platelet-to-lymphocyte ratio in patients with urothelial carcinoma

A large number of studies have investigated the prognostic value of the platelet-to-lymphocyte ratio (PLR) in patients diagnosed with urothelial carcinoma, but the evidence from these papers is conflicting. This systematic review and meta-analysis was carried out to assess the role of PLR in urothelial carcinoma patients. After a systematic search of the PubMed, Embase, Web of science databases, the associations between PLR and overall survival (OS), cancer-specific survival (CSS)/disease-specific survival (DSS), and relapse-free survival (RFS)/disease-free survival (DFS) were analyzed in urothelial carcinoma patients. The relationship between PLR and pathological results was also evaluated. A total of seven studies (eight cohorts) comprising 3171 patients were included. The pooled hazard ratios (HRs) and 95% confidence intervals (CIs) indicated the increased preoperative PLR predicted poor OS (HR = 1.14, 95% CI = 1.01- 1.27, p < 0.001), CSS/DSS (HR = 1.24, 95% CI = 1.08–1.40, p < 0.001), RFS/DFS (HR = 1.23, 95% CI = 1.09–1.38, p < 0.001). However, no significant correlation was found between elevated preoperative PLR and pathological results such as tumor grade, tumor necrosis and T stages. These findings suggest a high PLR is associated with reduced OS, CSS/DSS and RFS/DFS in urothelial carcinoma. Preoperative PLR may therefore be a predictive factor in this patient group.
Coreference in Wikipedia: Main Concept Resolution

Wikipedia is a resource of choice exploited in many NLP applications, yet we are not aware of recent attempts to adapt coreference resolution to this resource. In this work, we revisit a seldom studied task which consists in identifying in a Wikipedia article all the mentions of the main concept being described. We show that by exploiting the Wikipedia markup of a document, as well as links to external knowledge bases such as Freebase, we can acquire useful information on entities that helps to classify mentions as coreferent or not. We designed a classifier which drastically outperforms fair baselines built on top of state-of-the-art coreference resolution systems. We also measure the benefits of this classifier in a full coreference resolution pipeline applied to Wikipedia texts.
Fast Two Dimensional Convex Hull on the GPU

General purpose programming on the graphics processing units(GPGPU) has received a lot of attention in the parallel computing community as it promises to offer a large computational power at a very low price. GPGPU is best suited for regular data parallel algorithms. They are not directly amenable for algorithms which have irregular data access patterns such as convex hull, list ranking etc. In this paper, we present a GPU-optimized implementation for finding the convex hull of a two dimensional point set. Our implementation tries to minimize the impact of irregular data access patterns. Our implementation can find the convex hull of 10 million random points in less than 0.2 seconds and achieves a speedup of up to 14 over the standard sequential CPU implementation. We also discuss some of the practical issues relating to the implementation of convex hull algorithms on massively multi-threaded architectures like that of the GPU.