Miracle-dz/UniFAR-FTUs huggingface dataset:
Annexin A6 modifies muscular dystrophy by mediating sarcolemmal repair

Significance Many forms of muscular dystrophy produce muscle weakness through injury to skeletal muscle myofibers and specifically disruption of the muscle plasma membrane. Using a mouse model of muscular dystrophy in a genetically diverse background, a genome-wide scan for genetic modifiers was undertaken. A modifier locus that altered plasma membrane leak was interrogated, and a splice site variant in Anxa6, encoding annexin A6, was identified. The Anxa6 splice site produces a truncated annexin A6 protein. The truncated annexin A6 protein was found to inhibit membrane repair by disrupting the formation of the normal annexin A6-rich cap and repair zone. These data demonstrate annexin A6's role in muscle membrane leak and repair in muscular dystrophy. Many monogenic disorders, including the muscular dystrophies, display phenotypic variability despite the same disease-causing mutation. To identify genetic modifiers of muscular dystrophy and its associated cardiomyopathy, we used quantitative trait locus mapping and whole genome sequencing in a mouse model. This approach uncovered a modifier locus on chromosome 11 associated with sarcolemmal membrane damage and heart mass. Whole genome and RNA sequencing identified Anxa6, encoding annexin A6, as a modifier gene. A synonymous variant in exon 11 creates a cryptic splice donor, resulting in a truncated annexin A6 protein called ANXA6N32. Live cell imaging showed that annexin A6 orchestrates a repair zone and cap at the site of membrane disruption. In contrast, ANXA6N32 dramatically disrupted the annexin A6-rich cap and the associated repair zone, permitting membrane leak. Anxa6 is a modifier of muscular dystrophy and membrane repair after injury.
Turnover of highly educated R&D professionals: The role of pre-entry cognitive style, work values and career orientation

Retention of key R&D experts has been recognized as a critical managerial challenge for many technology-based companies. In this study, we propose that turnover of highly educated professional workers is meaningfully related to individual characteristics such as cognitive style, work values and career orientation. We tested the hypotheses using data collected from a sample of 132 R&D professionals with PhD degrees in engineering or natural science in a Korean electronics firm. The time-dependent risk of turnover was estimated by survival analysis using a proportional hazards regression model. The results showed that over the 7-year period after their organizational entry, R&D professionals with high levels of intrinsic values and cosmopolitan orientation were more likely to leave the organization than were their counterparts with low levels of intrinsic values and cosmopolitan orientation. The hazard function showed that the positive effect of intrinsic work values on turnover was particularly salient in the third and fourth year of R&D professionals' organizational tenure. We found that the positive effect of cosmopolitan orientation on turnover increased over time, introducing a greater risk of turnover with increasing tenure. The present findings have practical implications for the retention of highly educated R&D professionals in a corporate setting.
Extraversion predicts individual differences in face recognition

In daily life, one of the most common social tasks we perform is to recognize faces. However, the relation between face recognition ability and social activities is largely unknown. Here we ask whether individuals with better social skills are also better at recognizing faces. We found that extraverts who have better social skills correctly recognized more faces than introverts. However, this advantage was absent when extraverts were asked to recognize non-social stimuli (e.g., flowers). In particular, the underlying facet that makes extraverts a better face recognizer was mainly due to the gregariousness facet that measures the degree of inter-personal interaction. In addition, the link between Extraversion and face recognition ability was independent of general cognitive abilities. These findings provide the first evidence that links face recognition ability to our daily activity in social communication, supporting the hypothesis that extraverts are better at decoding social information than introverts.
The social context of violent victimization: A study of the delinquent peer effect

Haynie's (2001) work on the structural dimensions of peer networks demonstrated how the characteristics of networks may influence individual delinquent behavior. This study extends the network approach to the prediction of violent victimization. The National Longitudinal Survey of Adolescent Health (Add Health) is used to examine how the friendship-network characteristics of centrality, density, and popularity affect vulnerability. The findings indicate that central and popular members of dense conventional groups experienced lower levels of violent victimization, while the opposite was true of similarly situated members of delinquent networks. Implications for victimization and research related to the specification of how delinquent peer associations promote vulnerability are discussed.
Evidences of the gender‐related differences in cardiac repolarization and the underlying mechanisms in different animal species and human

Clinical and experimental studies have shown that gender differences exist in cardiac repolarization in various animal species and human, as is evidenced by significantly longer QT, JT intervals and action potential duration in females than in males due to a reduced repolarization reserve in females. The latter is shown by the relatively greater increase in ventricular repolarization and higher incidence of torsades de pointes (TdP) in preparations from females by drugs blocking repolarizing K+ currents. These results can be modulated by gonadectomy, suggesting that gonadal steroids are important determinants of gender difference in repolarization. In human subjects, QT and JT intervals are longer in women, whereas QT dispersion and Tp‐e interval (the interval from the peak to the end of T wave) are longer in men. At slow heart rates greater prolongation in QT and increase in transmural repolarization heterogeneity (i.e. increase in Tp‐e) may predispose to TdP tachycardias in women. In healthy postmenopausal women, hormone replacement therapy with estrogen alone usually produced a prolongation of QT interval, while estrogen plus progesterone had no significant effects on QT interval but reduced QT dispersion. Along with these, there are still conflicting data reported. Further work is needed before the elucidation of the basis of gender differences in ventricular repolarization.
An investigation into instrumental pupils' attitudes to varied, structured practice: two methods of approach

This research project was initiated to study how instrumental pupils might respond to different practice methods assigned to them, and to explore pupils' perceptions of their own achievements at the end of the five-week study. Pupils were asked to choose one of two methods of practising: they could either do straightforward repetitions of short phrases in their music, or they could choose a set number of different repetitions from a menu of options listed on three graded pro forma cards. A description of the method is included as well as the data from pupils' returned questionnaires. Results of the study suggest that pupils not only preferred variety and choice of practice techniques, but also found that their learning process was faster and more effective. Recommendations are made, as there are implications here for instrumental teachers, class music teachers and their pupils.
Activity Engagement as Escape from Self: The Role of Self-Suppression and Self-Expansion

A two-dimensional model on escape motives in activity engagement was developed in three studies. We suggested that motivation to escape the self through engagement in an activity partly derives from intentions to either prevent negative affect or to promote positive affect. A scale for measuring these intentional mindsets was developed consisting of the subcategories self-suppression and self-expansion. Results showed that the dimensions were differently related to psychological predictors, outcomes, and experiences in the activity engagement. We argue that the present research introduces escapism as a relevant theoretical and empirical concept applicable to several types of activity engagements.
Optimizing Region Selection for Weakly Supervised Object Detection

Training object detectors with only image-level annotations is very challenging because the target objects are often surrounded by a large number of background clutters. Many existing approaches tackle this problem through object proposal mining. However, the collected positive regions are either low in precision or lack of diversity, and the strategy of collecting negative regions is not carefully designed, neither. Moreover, training is often slow because region selection and object detector training are processed separately. In this context, the primary contribution of this work is to improve weakly supervised detection with an optimized region selection strategy. The proposed method collects purified positive training regions by progressively removing easy background clutters, and selects discriminative negative regions by mining class-specific hard samples. This region selection procedure is further integrated into a CNN-based weakly supervised detection (WSD) framework, and can be performed in each stochastic gradient descent mini-batch during training. Therefore, the entire model can be trained end-to-end efficiently. Extensive evaluation results on PASCAL VOC 2007, VOC 2010 and VOC 2012 datasets are presented which demonstrate that the proposed method effectively improves WSD.
Compartmentalization of ascites and edema in patients with hepatic cirrhosis.

Abstract Compartmentalization of ascites and nonascitic fluid was demonstrated in cirrhotic patients treated with dietary sodium restriction, diuretic therapy or paracentesis. Disparity between ascitic and nonascitic fluid absorption rates, evident during spontaneous diuresis, was exaggerated by diuretic administration. Despite rapid diuresis maximum ascites absorption rate was 930 ml per 24 hours — close to the rate of intraperitoneal saline absorption by noncirrhotic human subjects. After paracentesis ascitic fluid re-formed at as much as three and a half times the maximum absorption rate. It began to form during the paracentesis procedure and continued at a gradually decreasing rate for three to four days. The ascites formed largely by a shift of nonascitic fluid to the peritoneal cavity. However, some patients also formed ascites from retained exogenous fluid; they gained weight, and mild dilutional hyponatremia developed. Compartmentalization of ascites and edema probably causes some complications th.
The Perceived Relative Strength of the Therapeutic Alliance

ABSTRACT The association between the perceived relative strength of the therapeutic alliance in couples therapy and psychotherapeutic outcome was investigated. The perceived relative strength of the couples therapeutic alliance was classified into three categories: a balancedalliance (an individual perceives his/her own alliance and the partner's alliance as approximately equal in strength), a positively biasedor blessedalliance (an individual perceives his/her alliance as stronger than the perception of the partner's alliance) and a negatively biasedor just biasedalliance (an individual perceives his/her alliance as weaker than the perception of the partner's alliance). The impact of a consensus or non-consensus within each partner about the perceived relative strength of the alliance on outcome was also investigated. The Alliance Inventory for Couples was used as a measure of the alliance and outcome was assessed with the Family Environment Scale and the Marital Satisfaction Scale. No statistically reliable relation was found between perceived relative strength of the alliance and improved outcome. Consensus was also not predictive of outcome. These findings failed to confirm previous theoretical propositions and empirical research. Possible reasons for discrepancies between the current findings and previous research are provided. The distinction between perceived strength and strength based upon independent self-report measures; and the designation of biased, blessed and balanced alliances merit future research.
Play's relation to health and well-being in preschool and kindergarten: a Waldorf (Steiner) education perspective

In most US pre-k/kindergartens play is justified as serving academic goals. However, Waldorf education, an independent alternative to public schooling, leverages play to promote child health and well-being. This paper examines Waldorf education's approach to play with reference to the underlying cultural model of/for child development that Waldorf teachers subscribe to. It describes how teachers orchestrated play in four pre-k/kindergarten classrooms and examines, from the teacher perspective, how keeping children ‘in movement’ both physically and spiritually encourages healthful sensory-motor integration while nourishing children's ‘will forces’ and ensuring good health and flexible thinking in adulthood. In addition to providing insight into how we might foster more play in non-Waldorf settings and informing the theoretical construction of play-as-mood, the findings indicate that Waldorf education is not immune to the work-play opposition common to US educational discourse; accordingly, the pedagogic and pediatric work done by play becomes a selling point for the system.
Deceptive Language by Innocent and Guilty Criminal Suspects

This study proposed that criminal guilt interacts with dominance and interview question to affect linguistic properties during criminal interviews. A field experiment tested effects of criminal guilt, dominance, and question on linguistic properties of suspects’ responses using a 2 (criminal guilt: guilty/innocent) × 4 (question: Q1/Q2/Q3/Q4) mixed-model design with dominance as a covariate and question as a repeated factor. Analysis of linguistic properties from 37 criminal interviews indicated a hypothesized two-way interaction among dominance and guilt on immediacy and a three-way interaction among dominance, question, and guilt on complexity explored as part of the research question. Several other direct effects for dominance and question were noted. Implications, limitations, and future research directions are discussed.
Using more realistic data models to evaluate sensor network data processing algorithms

Due to lack of experimental data and sophisticated models derived from such data, most data processing algorithms from the sensor network literature are evaluated with data generated from simple parametric models. Unfortunately, the type of data input used in the evaluation often significantly affects the algorithm performance. Our case studies of a few widely-studied sensor network data processing algorithms demonstrated the need to evaluate algorithms with data across a range of parameters. In conclusion, we propose our synthetic data generation framework.
Current understanding of the role of B cell subsets and intimal and adventitial B cells in atherosclerosis

Purpose of review Inflammation, in addition to high cholesterol is a major factor contributing to atherosclerosis-associated adverse cardiovascular events. Thus, there is a pressing need for additional therapeutic strategies to reduce inflammation, by targeting immune cells and cytokines. Here we review B cell subsets and adventitial and intimal B cells in atherosclerosis development and discuss potential B cell-targeted anti-inflammatory therapies for atherosclerosis. Recent findings B cell subsets can have opposing proatherogenic and atheroprotective roles in atherosclerosis. CD-20-targeted B cell depletion has been shown to decrease murine atherosclerotic lesions. The accumulation of intimal and adventitial B cells associated with atherosclerotic lesions is consistent with their participation in local inflammatory responses. As B2 B cells are proatherogenic, blocking its survival factor B cell activating factor may selectively delete this proatherogenic subset. Summary Both intimal and adventitial B cells appear important in atherosclerosis. B2 B cells are proatherogenic and other subsets such as regulatory B cells are antiatherogenic. Future B cell-targeted therapy for atherosclerosis should be customized to selectively deplete damaging B2 B cells while sparing or expanding protective B cell subsets.
Single session of integrated “silver yoga” program improves cardiovascular parameters in senior citizens

Aim and Objective: This pilot study was carried out to determine cardiovascular effects of a single session of an integrated “silver yoga” program in senior citizens of Serene Pelican Township, Pondicherry. Materials and Methods: Heart rate (HR) and blood pressure (BP) measurements were recorded in 124 senior citizens (75 female, 49 male) with mean age of 67.19 ± 10.61 year who attended an integrated “Silver Yoga” program at Centre for Yoga Therapy, Education and Research from August to October 2014. Participants practiced the protocol that was specially designed for senior citizens, keeping in mind their health status and physical limitations. This included simple warm-ups (jathis), breath body movement coordination practices (kriyas), static stretching postures (asanas), breathing techniques (pranayamas), relaxation and simple chanting. Non-invasive BP apparatus was used to record the HR, systolic (SP) and diastolic pressure (DP) before and after the 60 min sessions. Pulse pressure (PP), mean pressure (MP), rate-pressure product (RPP) and double product (DoP) indices were derived from the recorded parameters. Student’s paired t-test was used to compare data that passed normality testing by Kolmogorov–Smirnov Test and Wilcoxon matched-pairs signed-ranks test for those that did not. P < 0.05 were accepted as indicating significant differences for pre-post comparisons. Results: All parameters witnessed a reduction following the single session. This was statistically more significant (P < 0. 0001) in HR, RPP and DoP while it was also significant (P < 0.01 and P < 0.05) in SP and PP, respectively. The decrease in MP just missed significance (P = 0.054) while it was not significant in DP. Conclusion: There is a healthy reduction in HR, BP and derived cardiovascular indices following a single yoga session in geriatric subjects. These changes may be attributed to enhanced harmony of cardiac autonomic function as a result of coordinated breath-body work and mind-body relaxation due to an integrated “Silver Yoga” program.
Association of Single Nucleotide Polymorphisms in Wnt Signaling Pathway Genes with Breast Cancer in Saudi Patients

Breast cancer is a complex heterogeneous disease involving genetic and epigenetic alterations in genes encoding proteins that are components of various signaling pathways. Candidate gene approach have identified association of genetic variants in the Wnt signaling pathway genes and increased susceptibility to several diseases including breast cancer. Due to the rarity of somatic mutations in key genes of Wnt pathway, we investigated the association of genetic variants in these genes with predisposition to breast cancers. We performed a case-control study to identify risk variants by examining 15 SNPs located in 8 genes associated with Wnt signaling. Genotypic analysis of individual locus showed statistically significant association of five SNPs located in β-catenin, AXIN2, DKK3, SFRP3 and TCF7L2 with breast cancers. Increased risk was observed only with the SNP in β-catenin while the other four SNPs conferred protection against breast cancers. Majority of these associations persisted after stratification of the cases based on estrogen receptor status and age of on-set of breast cancer. The rs7775 SNP in exon 6 of SFRP3 gene that codes for either arginine or glycine exhibited very strong association with breast cancer, even after Bonferroni's correction. Apart from these five variants, rs3923086 in AXIN2 and rs3763511 in DKK4 that did not show any association in the overall population were significantly associated with early on-set and estrogen receptor negative breast cancers, respectively. This is the first study to utilize pathway based approach to identify association of risk variants in the Wnt signaling pathway genes with breast cancers. Confirmation of our findings in larger populations of different ethnicities would provide evidence for the role of Wnt pathway as well as screening markers for early detection of breast carcinomas.
Gender-Divergent Profile of Bile Acid Homeostasis during Aging of Mice

Aging is a physiological process with a progressive decline of adaptation and functional capacity of the body. Bile acids (BAs) have been recognized as signaling molecules regulating the homeostasis of glucose, lipid, and energy. The current study characterizes the age-related changes of individual BA concentrations by ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) in serum and liver of male and female C57BL/6 mice from 3 to 27 months of age. Total BA concentrations in serum increased 340% from 3 to 27 months in female mice, whereas they remained relatively constant with age in male mice. During aging, male and female mice shared the following changes: (1) BA concentrations in liver remained relatively constant; (2) the proportions of beta-muricholic acid (βMCA) increased and deoxycholic acid (DCA) decreased between 3 and 27 months in serum and liver; and (3) total BAs in serum and liver became more hydrophilic between 3 and 27 months. In female mice, (1) the mRNAs of hepatic BA uptake transporters, the Na+/taurocholate cotransporting polypeptide (Ntcp) and the organic anion transporting polypeptide 1b2 (Oatp1b2), decreased after 12 months, and similar trends were observed for their proteins; (2) the mRNA of the rate-limiting enzyme for BA synthesis, cholesterol 7α-hydroxylase (Cyp7a1), increased from 3 to 9 months and remained high thereafter. However, in male mice, Ntcp, Oatp1b2, and Cyp7a1 mRNAs remained relatively constant with age. In summary, the current study shows gender-divergent profiles of BA concentrations and composition in serum and liver of mice during aging, which is likely due to the gender-divergent expression of BA transporters Ntcp and Oatp1b2 as well as the synthetic enzyme Cyp7a1.