Miracle-dz/UniFAR-FTUs huggingface dataset:
The other face of depression, reduced positive affect: the role of catecholamines in causation and cure

Despite significant advances in pharmacologic therapy of depression over the past two decades, a substantial proportion of patients fail to respond or experience only partial response to serotonin re-uptake inhibitor antidepressants, resulting in chronic functional impairment. There appears to be a pattern of symptoms that are inadequately addressed by serotonergic antidepressants — loss of pleasure, loss of interest, fatigue and loss of energy. These symptoms are key to the maintenance of drive and motivation. Although these symptoms are variously defined, they are consistent with the concept of `decreased positive affect'. Positive affect subsumes a broad range of positive mood states, including feelings of happiness (joy), interest, energy, enthusiasm, alertness and selfconfidence. Although preliminary, there is evidence to suggest that antidepressants that enhance noradrenergic and dopaminergic activity may afford a therapeutic advantage over serotonergic antidepressants in the treatment of symptoms associated with a reduction in positive affect. Dopaminergic and noradrenergic agents, including the dual acting norepinephrine and dopamine re-uptake inhibitors, have demonstrated antidepressant activity in the absence of serotonergic function, showing similar efficacy to both tricyclic and serotonin re-uptake inhibitor antidepressants. Moreover, the norepinephrine and dopamine re-uptake inhibitor bupropion has been shown to significantly improve symptoms of energy, pleasure and interest in patients with depression with predominant baseline symptoms of decreased pleasure, interest and energy. Focusing treatment on the predominant or driving symptomatology for an individual patient with major depression could potentially improve rates of response and remission.
Is magnetogenetics the new optogenetics?

Optogenetics has revolutionised neuroscience as it enables investigators to establish causal relationships between neuronal activity and a behavioural outcome in a temporally precise manner. It is a powerful technology, but limited by the necessity to deliver light to the cells of interest, which often requires invasive surgery and a tethered light source. Magnetogenetics aims to overcome these issues by manipulating neurons with magnetic stimuli. As magnetic fields can pass freely through organic tissue, it requires no surgery or tethering the animals to an energy source. In this commentary, we assess the utility of magnetogenetics based on three different approaches: magneto‐thermo‐genetics; force/torque‐based methods; and expression of the iron chaperone ISCA1. Despite some progress, many hurdles need to be overcome if magnetogenetics is to take the helm from optogenetics.
Dietary Protective and Risk Factors for Esophageal and Stomach Cancers in a Low‐epidemic Area for Stomach Cancer in Jiangsu Province, China: Comparison with Those in a High‐epidemic Area

Comparative epidemiological studies with ecological and case‐control approaches in high‐ and low‐epidemic areas of China have provided us with much evidence with regard to risk and benefit in the environment. To clarify how dietary factors are involved in esophageal and stomach cancer development, we performed a case‐control study in a low‐epidemic area, and compared the findings with those obtained earlier for a high‐epidemic area for stomach cancer in the same Jiangsu Province, China. We recruited 199 and 187 cases with esophageal and stomach cancers, respectively, and 333 population‐based common controls. Odds ratios (ORs) for esophageal and stomach cancers were calculated with adjustment for potential confounding factors, using an unconditional logistic model. Current and former smoking elevated the OR for esophageal cancer, along with high intake of pickled vegetables and broiled meat, while decreased ORs were observed for frequently consumed raw vegetables and garlic. With regard to stomach cancer, ORs were increased with frequent consumption of salty fish, leftover gruel, and broiled meat, and lowered by snap bean consumption. The present risk factors were common to the previously obtained results in the high‐epidemic area, and similarly distributed in each general population. While more protective factors were observed in the high‐epidemic area, their penetrance was much greater in the low‐epidemic area. The present study thus suggests that frequent vegetable and garlic consumption contributes to low mortality rates for esophageal and stomach cancers in a low‐epidemic area, counteracting similar exposure levels for risk factors as in the high‐epidemic area .
A design concept for N-dimensional user interfaces

We describe a classification concept, that allows us to discriminate four different domains: the dimension of the internal world model, presentation effects based on different techniques, perception mechanism, and the conceptualization of the world's dimensions in the user's mental model. This classification concept is applied to visual depth cues and acoustical signals. The user's perceptual feeling of being immersed in the context of virtual interfaces can be achieved by different presentation effects based on several techniques. ⁄A major problem in designing n-D user interfaces is the fact, that designers do not have any metrics or benchmarks for applying the optimal software and hardware setting given a certain task. Different experiments for the visual information processing channel show, that, for example, depth cues for monocular perception are often sufficient versus binocular depth cues (often called stereo). Experiments show that combining different presentation and inter–action techniques in a synergetic way may give further advantages for the effectiveness of n-D user interfaces.
Substrate specificity of the cdk‐activating kinase (CAK) is altered upon association with TFIIH

The transcription/DNA repair factor TFIIH consists of nine subunits, several exhibiting known functions: helicase/ATPase, kinase activity and DNA binding. Three subunits of TFIIH, cdk7, cyclin H and MAT1, form a ternary complex, cdk‐activating kinase (CAK), found either on its own or as part of TFIIH. In the present work, we demonstrate that purified human CAK complex (free CAK) and recombinant CAK (rCAK) produced in insect cells exhibit a strong preference for the cyclin‐dependent kinase 2 (cdk2) over a ctd oligopeptide substrate (which mimics the carboxy‐terminal domain of the RNA polymerase II). In contrast, TFIIH preferentially phosphorylates the ctd as well as TFIIEα, but not cdk2. TFIIH was resolved into four subcomplexes: the kinase complex composed of cdk7, cyclin H and MAT1; the core TFIIH which contains XPB, p62, p52, p44 and p34; and two other subcomplexes in which XPD is found associated with either the kinase complex or with the core TFIIH. Using these fractions, we demonstrate that TFIIH lacking the CAK subcomplex completely recovers its transcriptional activity in the presence of free CAK. Furthermore, studies examining the interactions between TFIIH subunits provide evidence that CAK is integrated within TFIIH via XPB and XPD.
Generic Attacks on Secure Outsourced Databases

Recently, various protocols have been proposed for securely outsourcing database storage to a third party server, ranging from systems with "full-fledged" security based on strong cryptographic primitives such as fully homomorphic encryption or oblivious RAM, to more practical implementations based on searchable symmetric encryption or even on deterministic and order-preserving encryption. On the flip side, various attacks have emerged that show that for some of these protocols confidentiality of the data can be compromised, usually given certain auxiliary information. We take a step back and identify a need for a formal understanding of the inherent efficiency/privacy trade-off in outsourced database systems, independent of the details of the system. We propose abstract models that capture secure outsourced storage systems in sufficient generality, and identify two basic sources of leakage, namely access pattern and ommunication volume. We use our models to distinguish certain classes of outsourced database systems that have been proposed, and deduce that all of them exhibit at least one of these leakage sources. We then develop generic reconstruction attacks on any system supporting range queries where either access pattern or communication volume is leaked. These attacks are in a rather weak passive adversarial model, where the untrusted server knows only the underlying query distribution. In particular, to perform our attack the server need not have any prior knowledge about the data, and need not know any of the issued queries nor their results. Yet, the server can reconstruct the secret attribute of every record in the database after about $N^4$ queries, where N is the domain size. We provide a matching lower bound showing that our attacks are essentially optimal. Our reconstruction attacks using communication volume apply even to systems based on homomorphic encryption or oblivious RAM in the natural way. Finally, we provide experimental results demonstrating the efficacy of our attacks on real datasets with a variety of different features. On all these datasets, after the required number of queries our attacks successfully recovered the secret attributes of every record in at most a few seconds.
Scale effects in metal-forming friction and lubrication

Downscaling of metal-forming operations from macro- to microscale implies significant changes caused by size effects. Among these, the friction increases as reported by researchers using indirect test methods such as the ring-compression test and double-cup-extrusion test. In this study, a new test equipment is developed for studies of the size effect in metal-forming friction in the range from macro- to microscale. Investigations confirm a significant friction increase when downscaling. Visual inspection of the workpieces shows this to be explained by the amount of open and closed lubricant pockets.
Electric-field controlled ferromagnetism in MnGe magnetic quantum dots

Electric-field control of ferromagnetism in magnetic semiconductors at room temperature has been actively pursued as one of the important approaches to realize practical spintronics and non-volatile logic devices. While Mn-doped III-V semiconductors were considered as potential candidates for achieving this controllability, the search for an ideal material with high Curie temperature (Tc>300 K) and controllable ferromagnetism at room temperature has continued for nearly a decade. Among various dilute magnetic semiconductors (DMSs), materials derived from group IV elements such as Si and Ge are the ideal candidates for such materials due to their excellent compatibility with the conventional complementary metal-oxide-semiconductor (CMOS) technology. Here, we review recent reports on the development of high-Curie temperature Mn0.05Ge0. 95 quantum dots (QDs) and successfully demonstrate electric-field control of ferromagnetism in the Mn0.05Ge0. 95 quantum dots up to 300 K. Upon the application of gate-bias to a metal-oxide-semiconductor (MOS) capacitor, the ferromagnetism of the channel layer (i.e. the Mn0.05Ge0.95 quantum dots) was modulated as a function of the hole concentration. Finally, a theoretical model based upon the formation of magnetic polarons has been proposed to explain the observed field controlled ferromagnetism.
Experience Maps: Experience-Enhanced Routes for Car Navigation

People spend a considerable time per day driving a car. Navigation technology helps the driver to find a location, to see traffic details, or to estimate the arrival time. Selecting a certain route influences the driving experience (i.e., the user experience while driving) through factors such as traffic density, landscape, or road type. However, current navigation systems mainly optimize routes regarding time, distance, or fuel efficiency--neglecting important driving experience factors: The fastest route might still be packed with traffic which stresses drivers or negatively influence their mood. In contrast, a slightly slower route could for instance offer a better driving experience with less traffic and scenic views. In this paper, we propose a concept that allows for experience-optimized routing to make driving more joyful and pleasurable. We also present the results of a web survey with 114 participants that we conducted to explore the users' preferences and opinions regarding taking the experience into account for route guidance.
Captopril for prevention of contrast-induced nephropathy in diabetic patients: a randomised study.

Contrast-induced nephrotoxicity is an important cause of hospital-acquired acute renal insufficiency. Different modalities have been used to prevent contrast induced-nephrotoxicity namely saline infusion, mannitol, furosemide, calcium channel blockers, atrial natriuretic factor and dopamine infusion with variable success. The possible role of medullary ischaemia mediated by renin angiotensin system in genesis of contrast-induced nephrotoxicity prompted us to investigate the role of captopril (a sulfhydryl group containing angiotensin-converting enzyme inhibitor) in its prevention. Seventy-one patients of diabetes mellitus undergoing coronary angiography were included in the study. Patients randomised to receive captopril, received the drug in a dose of 25 mg thrice a day for three days, starting one hour prior to angiography while the patients in the control group underwent angiography in a routine manner without receiving captopril. Following angiography, patients in the control group developed a significant increase in serum creatinine and blood urea nitrogen levels, as compared to those who received captopril. Contrast-induced nephrotoxicity (i.e. a rise of 0.5 mg/dL in serum creatinine) developed in 29 percent of the control group. Administration of captopril reduced the risk of development of contrast-induced nephrotoxicity by 79 percent. Glomerular filtration rate as measured by Tc DTPA renal scanning prior to and 24-72 hours following angiography demonstrated a mean fall of 9.6 ml/min in the control group while those in the captopril group had a mean increase of 13 ml/min in glomerular filtration rate. We conclude that abnormalities of renal perfusion possibly mediated by renin angiotensin system are responsible for development of contrast-induced nephrotoxicity. Administration of the angiotensin-converting enzyme inhibitor, captopril, offers protection against development of contrast-induced nephrotoxicity.
Shackled to the Status Quo: The Inhibiting Effects of Incumbent System Habit, Switching Costs, and Inertia on New System Acceptance

Given that adoption of a new system often implies fully or partly replacing an incumbent system, resistance is often manifested as failure of a user to switch from an incumbent technology to a newly introduced one. Thus, a potential source of resistance to adopting a new system lies in the use of an incumbent system. Using the status quo bias and habit literatures as theoretical lenses, the study explains how use of an incumbent system negatively impacts new system perceptions and usage intentions. We argue that habitual use of an incumbent system, rationalization due to perceived transition costs, and psychological commitment due to perceived sunk costs all encourage development of inertia. Inertia in turn fully mediates the impact of these incumbent system constructs on constructs related to acceptance of the new system via psychological commitment based on cognitive consistency and by increasing the importance of normative pressures. Specifically, we hypothesize that inertia leads to decreased perceptions of the ease of use and relative advantage of a newly introduced system and has a negative impact on intentions to use the new system, above and beyond its impact through perceptions. Finally, we hypothesize that inertia moderates the relationship between subjective norm and intention, such that normative pressures to use a new system become more important in the presence of inertia. Empirical results largely support the hypothesized relationships showing the inhibiting effect of incumbent-system habit, transition and sunk costs, and inertia on acceptance of a new system. Our study thus extends theoretical understanding of the role of incumbent system constructs such as habit and inertia in technology acceptance, and lays the foundations for further study of the interplay between perceptions and cognition with respect to the incumbent system and those with respect to a new system.
Influence of Stress in Parents on Child Obesity and Related Behaviors

OBJECTIVE: To assess associations of the number of parent stressors and parent-perceived stress with obesity and related behaviors in their children. METHODS: This cross-sectional analysis used data from the 2006 Southeastern Pennsylvania Household Health Survey in which 2119 parents/caregivers answered questions about themselves and their children (ages 3–17 years). Survey data were used to assess the main exposure variables: the number of stressors (measured using a stressor index) and parent-perceived stress (the response to a general stress question); child covariates (age, race/ethnicity, health quality, and gender); adult covariates (education, BMI, gender, poor sleep quality) and study outcomes (child obesity, fast-food consumption, fruit and vegetable consumption, and physical activity). To account for developmental differences, analyses were also stratified by age group (3–5, 6–8, 9–12, and 13–17 years). Analyses used multiple logistic regression, with results expressed as odds ratios and 95% confidence intervals. RESULTS: The number of parent stressors was related to child obesity in unadjusted (1.12, 1.03–1.22, P = .007) and adjusted models (1.12, 1.03–1.23, P = .010). Parent-perceived stress was related to fast-food consumption in unadjusted (1.07, 1.03–1.10, P < .001) and adjusted (1.06, 1.02–1.10, P < .001) models. CONCLUSIONS: The number of parent stressors was directly related to child obesity. Parent-perceived stress was directly related to child fast-food consumption, an important behavioral indicator of obesity risk. Clinical care models and future research that address child obesity should explore the potential benefits of addressing parent stressors and parent-perceived stress.
Group recommendations with rank aggregation and collaborative filtering

The majority of recommender systems are designed to make recommendations for individual users. However, in some circumstances the items to be selected are not intended for personal usage but for a group; e.g., a DVD could be watched by a group of friends. In order to generate effective recommendations for a group the system must satisfy, as much as possible, the individual preferences of the group's members. This paper analyzes the effectiveness of group recommendations obtained aggregating the individual lists of recommendations produced by a collaborative filtering system. We compare the effectiveness of individual and group recommendation lists using normalized discounted cumulative gain. It is observed that the effectiveness of a group recommendation does not necessarily decrease when the group size grows. Moreover, when individual recommendations are not effective a user could obtain better suggestions looking at the group recommendations. Finally, it is shown that the more alike the users in the group are, the more effective the group recommendations are.
Vascular endothelial growth factor expression and signaling in the lens.

PURPOSE Previous studies have identified sequences encoding vascular endothelial growth factor (VEGF)-A and one of the VEGF receptors (VEGFR2, Flk-1, KDR) in lens fiber cells. The current study was undertaken to determine the distribution of VEGF-A protein in the lens, whether signaling through VEGF receptors occurs in lens cells, the pattern of VEGF-A expression during lens development, and the effect of hypoxia on VEGF-A expression. METHODS VEGF-A and VEGFR2 were localized using immunocytochemistry. VEGF-A and VEGFR2 protein were identified and quantified by Western blot analysis. Activated (tyrosine phosphorylated) VEGFR2 was detected by immunoprecipitation with an anti-phosphotyrosine antibody followed by Western blot analysis with antibody to VEGFR2. Levels of VEGF-A mRNA were measured by quantitative PCR. Suturing the lids of adult mouse or rabbit eyes for 3 days was used to induce lens hypoxia. RESULTS VEGFR2 sequences were present in adult human lens epithelial cells, and VEGF-A transcripts were detected in chicken embryo, adult human, and mouse lens epithelial cells. VEGF-A protein localized to the ends of mouse embryo lens fiber cells at developmental stages when the fetal vasculature was forming. At later stages, VEGF-A was distributed uniformly throughout the cytoplasm of cortical fiber cells. VEGFR2 was present in mouse lens epithelial and fiber cells and was tyrosine phosphorylated at all stages examined. VEGF-A protein was barely detectable in lens epithelial cells during the first postnatal week, but increased as the capillaries of the anterior pupillary membrane regressed. VEGF-A levels were highest in adult lenses. Suturing the eyelid caused an increase in VEGF-A mRNA and protein in lens epithelial and fiber cells. CONCLUSIONS VEGF-A secreted by lens cells may stimulate the formation of the fetal vasculature, but regression of these vessels is not likely to be caused by a reduction in VEGF-A production by the lens. An active VEGF-A signaling system of unknown function appears to be active in the lens. It is likely that VEGF-A expression is regulated by tissue hypoxia at all stages of lens development.
Reflect and learn together - when two supervisors interact in the learning support process of nurse education.

AIM To describe the importance of supervisors working together in supporting the learning process of nurse students through reflective caring science supervision. BACKGROUND A supervision model has been developed in order to meet the need for interweaving theory and practice. The model is characterized by learning reflection in caring science. A unique aspect of the present project was that the student groups were led by a teacher and a nurse. METHOD Data were collected through interviews with the supervisors. The analysis was performed with a phenomenological approach. RESULTS The results showed that theory and practice can be made more tangible and interwoven by using two supervisors in a dual supervision. The essential structure is built on the constituents 'Reflection as Learning Support', 'Interweaving Caring Science with the Patient's Narrative', 'The Student as a Learning Subject' and 'The Learning Environment of Supervision'. CONCLUSION The study concludes that supervision in pairs provides unique possibilities for interweaving and developing theory and practice. IMPLICATIONS FOR NURSING MANAGEMENT The supervision model offers unique opportunities for cooperation, for the development of theory and practice and for the development of the professional roll of nurses and teachers.