Miracle-dz/UniFAR-FTUs huggingface dataset:
Role of Rotational Kinematics in Minimizing Elbow Varus Torques for Professional Versus High School Pitchers

Background: Elbow injury rates among baseball pitchers are rapidly rising. However, this increase has been most dramatic among high school (HS) pitchers. Purpose: To examine pitch velocity and the kinetic and kinematic characteristics of HS versus professional (PRO) pitchers to identify potential differences that may play a role in the increased risk of ulnar collateral ligament injury in youth pitchers. Study Design: Controlled laboratory study. Methods: A total of 37 HS (mean ± SD: age, 16 ± 1 years) and 40 PRO (age, 21 ± 2 years) baseball pitchers completed maximal-effort baseball pitches during a single testing session, from which pitch velocity (PV), absolute and normalized elbow varus torque (EVTA and EVTN, respectively) during arm cocking and at maximum shoulder external rotation (MER), and 8 other elbow and shoulder torques or forces and rotational kinematics of the pelvis and trunk were analyzed, recorded, and compared. Results: PV was greater in PRO than HS athletes; EVTA was greater in PRO than HS athletes during arm cocking and at MER; but EVTN was similar during arm cocking and greater in HS than PRO athletes at MER. In PRO athletes, PV was not related to EVTA during arm cocking or MER (r = 0.01-0.05). Furthermore, in PRO athletes, EVTA during arm cocking and at MER were inversely related to upper trunk rotation at hand separation and foot contact and to pelvis rotation at elbow extension (r = –0.30 to –0.33). In contrast, in HS athletes, PV was strongly related to EVTA during arm cocking and MER (r = 0.76-0.77). Furthermore, in HS athletes, PV and EVTA during arm cocking and at MER were moderately or strongly related to the other elbow and shoulder torques and forces (r = 0.424-0.991), and EVTA was not related to upper trunk rotation or pelvis rotation throughout the throwing motion (r = –0.16 to 0.15). Conclusion: The kinetic and rotational kinematic differences observed between PRO and HS pitchers in this study may help explain the greater performance of PRO pitchers while allowing them to minimize EVT during pitching. HS pitchers, however, do not appear to be as capable of utilizing the forces generated by rotation of their trunk and pelvis to aid in pitching, and those who throw the hardest generate the greatest forces at the shoulder and elbow. As a result, they experience higher EVTs relative to their body size, which may place them at an increased risk of injury. Clinical Relevance: HS pitchers throw harder primarily by generating larger forces in the arm and shoulder. Thus, owing to the relative physical immaturity of HS versus PRO pitchers, these factors may place them at an increased risk of injury. Coaches may first wish to focus on improving the rotational kinematics of HS pitchers rather than first focusing on achieving greater pitch velocities.
Static Stretching and Preconditioning Exercise Augments Power Output in Recreational Athletes

OF THESIS STATIC STRETCHING AND PRECONDITIONING EXERCISE AUGMENTS POWER OUTPUT IN RECREATIONAL ATHLETES The purpose of this study was to determine the independent and combined effects of performing a preconditioning exercise and antagonist stretching on vertical jump (VJ) performance. Twenty club rugby players performed a VJ in four conditions: control condition, following static stretching, following a preconditioning exercise, and following the combined treatment of static stretching and a preconditioning exercise. Electromyographic (EMG) activity was measured in the gluteus maximus, vastus lateralis, gastrocnemius medialis, and tibialis anterior during the VJ trials. Repeated measures ANOVA were used to compare VJ and EMG outcomes across conditions. A Bonferroni correction was used to account for multiple post-hoc comparisons (significance set at p < 0.0083). Despite a strong trend, there were no independent effects of performing the preconditioning exercise (p = 0.012 / Effect size = 0.29) and static stretching (p = 0.050; Effect size = 0.19) on VJ height compared to the control condition. However, the combined treatment increased VJ height 1.59 ± 1.42 cm compared to the control condition (p < 0.001, Effect size = 0.57). There were no significant differences in EMG outcomes between conditions. These findings indicate that performing a preconditioning exercise and statically stretching the antagonist muscles acutely augments lower body power output.
Parameterized Intractability of Even Set and Shortest Vector Problem from Gap-ETH

The $k$-Even Set problem is a parameterized variant of the Minimum Distance Problem of linear codes over $\mathbb F_2$, which can be stated as follows: given a generator matrix $\mathbf A$ and an integer $k$, determine whether the code generated by $\mathbf A$ has distance at most $k$. Here, $k$ is the parameter of the problem. The question of whether $k$-Even Set is fixed parameter tractable (FPT) has been repeatedly raised in literature and has earned its place in Downey and Fellows' book (2013) as one of the "most infamous" open problems in the field of Parameterized Complexity. In this work, we show that $k$-Even Set does not admit FPT algorithms under the (randomized) Gap Exponential Time Hypothesis (Gap-ETH) [Dinur'16, Manurangsi-Raghavendra'16]. In fact, our result rules out not only exact FPT algorithms, but also any constant factor FPT approximation algorithms for the problem. Furthermore, our result holds even under the following weaker assumption, which is also known as the Parameterized Inapproximability Hypothesis (PIH) [Lokshtanov et al.'17]: no (randomized) FPT algorithm can distinguish a satisfiable 2CSP instance from one which is only $0.99$-satisfiable (where the parameter is the number of variables). We also consider the parameterized $k$-Shortest Vector Problem (SVP), in which we are given a lattice whose basis vectors are integral and an integer $k$, and the goal is to determine whether the norm of the shortest vector (in the $\ell_p$ norm for some fixed $p$) is at most $k$. Similar to $k$-Even Set, this problem is also a long-standing open problem in the field of Parameterized Complexity. We show that, for any $p > 1$, $k$-SVP is hard to approximate (in FPT time) to some constant factor, assuming PIH. Furthermore, for the case of $p = 2$, the inapproximability factor can be amplified to any constant.
Compassionate and self-image goals as interpersonal maintenance factors in clinical depression and anxiety.

OBJECTIVE Interpersonal models of depression and anxiety have not examined the role of interpersonal goals in shaping relationships and symptoms. Striving to promote/protect desired self-images (self-image goals) may undermine relationships and increase symptoms, whereas striving to support others (compassionate goals) may be protective, but clinical relevance is unknown. METHOD We tested effects of compassionate versus self-image goals on interpersonal functioning and symptoms in clinically depressed and/or anxious participants (N = 47) during 10 days of experience sampling, over a 6-week follow-up, and in a dyadic relationship. RESULTS Participants reported higher conflict and symptoms on days that they most pursued self-image goals, but noted higher perceived support and lower symptoms when pursuing compassionate goals. Goals prospectively predicted symptom changes 6 weeks later. Lastly, informant-rated interpersonal goals predicted relationship satisfaction of both patients and significant others. CONCLUSION Results suggest the relevance of self-image and compassionate goals for the interpersonal maintenance of depression and anxiety.
Natural dietary compound naringin prevents azoxymethane/dextran sodium sulfate-induced chronic colorectal inflammation and carcinogenesis in mice

ABSTRACT Naringin, a natural occurring flavonoid compound, enriches in citrus fruits. We aimed to evaluate the inhibitory effect of naringin on colitis and chronic inflammation-driven carcinogenesis. Male C57BL/6 mice were exposed to AOM/DSS to induce colorectal inflammation and carcinogenesis. Naringin by oral administration prevented AOM/DSS-induced ulcerative colitis and carcinogenesis without significant side effects. Naringin attenuated the severity of colitis and colorectal adenomas through inhibiting myeloid-derived suppressor cells (MDSCs), pro-inflammatory mediators GM-CSF/M-CSF, IL-6 and TNF-α and the NF-κB/IL-6/STAT3 cascades in colorectal tissues. Naringin-treated mice exhibited normalized structures of colorectal tissues. Electron microscopy analysis showed the suppression of robust endoplasmic reticulum (ER) stress-induced autophagy. Naringin inhibited the secretion of the ER-spanning transmembrane proteins, such as GRP78 ATF6, IRE1α and activated PERK phosphorylated eIF-2α and complex of autophagosomes ATG3, ATG5, ATG7, ATG12, ATG16 and ATG16L1 in the colorectal mucosal cells. Conclusion: Naringin prevented colitis and colorectal carcinogenesis through suppressing robust ER stress-induced autophagy in colorectal mucosal cells. Naringin could develop a promising therapeutic agent for the prevention of ulcerative colitis and colorectal tumor.
Risk Factors for Poststroke Cognitive Decline: The REGARDS Study (Reasons for Geographic and Racial Differences in Stroke)

Background and Purpose— Poststroke cognitive decline causes disability. Risk factors for poststroke cognitive decline independent of survivors’ prestroke cognitive trajectories are uncertain. Methods— Among 22 875 participants aged ≥45 years without baseline cognitive impairment from the REGARDS cohort (Reasons for Geographic and Racial Differences in Stroke), enrolled from 2003 to 2007 and followed through September 2015, we measured the effect of incident stroke (n=694) on changes in cognitive functions and cognitive impairment (Six-Item Screener score <5) and tested whether patient factors modified the effect. Median follow-up was 8.2 years. Results— Incident stroke was associated with acute declines in global cognition, new learning, verbal memory, and executive function. Acute declines in global cognition after stroke were greater in survivors who were black (P=0.04), men (P=0.04), and had cardioembolic (P=0.001) or large artery stroke (P=0.001). Acute declines in executive function after stroke were greater in survivors who had <high school education versus college graduates (P=0.01). Incident stroke was associated with faster declines in global cognition and executive function but not new learning or verbal memory compared with prestroke slopes. Faster declines in global cognition over years after stroke were greater in survivors who were older (P<0.01), resided outside the Stroke Belt (P=0.005), or had cardioembolic stroke (P=0.01). Faster declines in executive function over years after stroke were greater in survivors who were older (P<0.01) or lacked hypertension (P=0.03). Conclusions— Incident stroke alters a patient’s cognitive trajectory, and this effect is greater with increasing age and cardioembolic stroke. Race, sex, geography, and hypertension status may modify the risk of poststroke cognitive decline.
Two birds with one stone: learning semantic models for text categorization and word sense disambiguation

In this paper we present a novel approach to learning semantic models for multiple domains, which we use to categorize Wikipedia pages and to perform domain Word Sense Disambiguation (WSD). In order to learn a semantic model for each domain we first extract relevant terms from the texts in the domain and then use these terms to initialize a random walk over the WordNet graph. Given an input text, we check the semantic models, choose the appropriate domain for that text and use the best-matching model to perform WSD. Our results show considerable improvements on text categorization and domain WSD tasks.
Explorations and perspectives on the neurobiological bases of autism spectrum disorder

John J. Foxe, Sophie Molholm, Stephane J. Baudouin and Mark T. Wallace Department of Neuroscience, The Ernest J. Del Monte Institute for Neuroscience, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA The Cognitive Neurophysiology Laboratory, Departments of Pediatrics and Neuroscience, Albert Einstein College of Medicine, Bronx, NY, USA School of Biosciences, Cardiff University, Cardiff, UK Center for Integrative and Cognitive Neuroscience, Vanderbilt University, Nashville, TN, USA
Implications of ICD-10 for Sarcopenia Clinical Practice and Clinical Trials: Report by the International Conference on Frailty and Sarcopenia Research Task Force

Establishment of an ICD-10-CM code for sarcopenia in 2016 was an important step towards reaching international consensus on the need for a nosological framework of age-related skeletal muscle decline. The International Conference on Frailty and Sarcopenia Research Task Force met in April 2017 to discuss the meaning, significance, and barriers to the implementation of the new code as well as strategies to accelerate development of new therapies. Analyses by the Sarcopenia Definitions and Outcomes Consortium are underway to develop quantitative definitions of sarcopenia. A consensus conference is planned to evaluate this analysis. The Task Force also discussed lessons learned from sarcopenia trials that could be applied to future trials, as well as lessons from the osteoporosis field, a clinical condition with many constructs similar to sarcopenia and for which ad hoc treatments have been developed and approved by regulatory agencies.
Genetic diversity of invasive alien species Lupinus polyphyllus populations in Lithuania.

After appearance in Lithuania at the beginning of the 20th century, large-leaved lupine (Lupinus polyphyllus Lindl.) has widely spread throughout the country inhabiting not only forests but also the forest outskirts, roadsides, abandoned uncultivated fields, and its further penetration into natural habitats is observed. The goal of the research was to study the intraspecific diversity of L. polyphyllus populations in forests and abandoned fields. Genetic diversity of L. polyphyllus populations of forests and abandoned fields was tested using the RAPD method. Genotypes of each population were investigated using six primers. The UPGMA dendrogram revealed that all plants are genetically different, but individuals of each population group together. AMOVA showed significant genetic differentiation of the investigated L. polyphyllus populations (ΦPT. = 0,444, p < 0,001). Neither UPGMA cluster analysis, nor principal coordinate analysis revealed population grouping regarding the geographic distance between them. On the other hand, UPGMA cluster analysis revealed genetic peculiarities of L. polyphyllus populations that probably are associated with adaptation of invasive populations to local conditions. Although L. polyphyllus is becoming one of the most aggressive invasive plant species, according to our data, this is just the first study on the genetic diversity of the invasive populations of this species using molecular markers.
Levator ani muscle injuries associated with vaginal vacuum assisted delivery determined by 3/4D transperineal ultrasound

Abstract Objectives: To determine the rate of pelvic floor trauma, levator ani muscle (LAM) avulsion as well as the mean difference in levator hiatus area, after normal vaginal deliveries (NVD) and vacuum assisted deliveries (VD), assessed with three-dimensional transperineal ultrasound (3D-TpUS). Materials and methods: Prospective observational study with 151 nulliparous women with NVD or VD at ≥37 weeks between 9-2012 and 6-2013. 3D-TpUS was performed six months after every patient’s delivery, during which LAM, anteroposterior diameter, transverse diameter and levator hiatus area were assessed. Results: A total of 146 nulliparous were studied, comprising 73 NVD and 73 VD. No differences in obstetric, intrapartum or neonatal characteristics were observed between study groups, with the following exceptions: maternal age (28.1 ± 5.4 versus 30.4 ± 5.5; p = 0.008, OR = 1.1) and episiotomy rate (35.6% versus 97.3%; p = 0.011, OR = 4.3). LAM avulsion rate was 9.6% in NVD versus 34.2% in VD (p = 0.001, OR 3.99), while levator hiatus area at rest was 16.5 ± 3.2 versus 18.2 ± 3.9 (p = 0.016). Conclusions: Vacuum assisted deliveries present a higher rate of LAM avulsion, as well as a greater increase in levator hiatal area than in NVD.
Understanding access to healthcare among Indigenous peoples: A comparative analysis of biomedical and postcolonial perspectives

As nursing professionals, we believe access to healthcare is fundamental to health and that it is a determinant of health. Therefore, evidence suggesting access to healthcare is problematic for many Indigenous peoples is concerning. While biomedical perspectives underlie our current understanding of access, considering alternate perspectives could expand our awareness of and ability to address this issue. In this paper, we critique how access to healthcare is understood through a biomedical lens, how a postcolonial theoretical lens can extend that understanding, and the subsequent implications this alternative view raises for the nursing profession. Drawing on peer‐reviewed published and gray literature concerning healthcare access and Indigenous peoples to inform this critique, we focus on the underlying theoretical lens shaping our current understanding of access. A postcolonial analysis provides a way of understanding healthcare as a social space and social relationship, presenting a unique perspective on access to healthcare. The novelty of this finding is of particular importance for the profession of nursing, as we are well situated to influence these social aspects, improving access to healthcare services broadly, and among Indigenous peoples specifically.
Quantification of beam steering with an ionization chamber array

Abstract Routine quality assurance for linear accelerators (linacs) usually involves verification of beam steering with a water scanning system. We established a beam steering procedure that uses a 2D ionization chamber array (ICA) and verified the equivalence of beam symmetry between the ICA and a water scanning system. The ICA calibration accuracy, reproducibility and stability were evaluated and the uncertainty in the measurement of beam symmetry due to the array calibration was examined. Forty‐five photon beams and 80 electron beams across 7 Varian C‐series and 4 TrueBeam linacs were steered in the radial and transverse directions using an ICA. After beam steering, profiles were re‐measured using the ICA and in‐water using a 3D Scanner (3DS). Beam symmetries measured with the ICA and 3DS were compared by (a) calculating the difference in point‐by‐point symmetry, (b) plotting the histogram distribution of the symmetry differences, and (c) comparing ICA and 3DS differences with their respective Varian symmetry protocol analysis. Array calibrations from five different occurrences (2012 to 2016) over six different beams reproduced within 0.5%. The uncertainty in beam symmetry was less than 0.5% due to the uncertainties in the array calibration. After all beams were steered using the ICA, the point‐by‐point symmetry differences between ICA and 3DS at the off‐axis positions of 20% and 80% of field size for all beam profiles indicated that 95% of point‐by‐point symmetry comparisons agreed within 0.7%, and 100% agreed within 1.0%; after steering with the ICA 97.8% of photon beam profiles (88 of 90) and 97.5% of electron beam profiles (156 of 160) had symmetry within 1% when measured with the 3DS. All photon and electron beam profiles had symmetry within 1.1% and 1.2%, respectively, for profiles measured with the 3DS. Our data demonstrate that a calibrated ICA can be used to steer photon and electron beams achieving beam symmetry within 1% when re‐measured with a 3D water scanning system.
In Planta Recapitulation of Isoprene Synthase Evolution from Ocimene Synthases

Abstract Isoprene is the most abundant biogenic volatile hydrocarbon compound naturally emitted by plants and plays a major role in atmospheric chemistry. It has been proposed that isoprene synthases (IspS) may readily evolve from other terpene synthases, but this hypothesis has not been experimentally investigated. We isolated and functionally validated in Arabidopsis the first isoprene synthase gene, AdoIspS, from a monocotyledonous species (Arundo donax L., Poaceae). Phylogenetic reconstruction indicates that AdoIspS and dicots isoprene synthases most likely originated by parallel evolution from TPS-b monoterpene synthases. Site-directed mutagenesis demonstrated invivo the functional and evolutionary relevance of the residues considered diagnostic for IspS function. One of these positions was identified by saturating mutagenesis as a major determinant of substrate specificity in AdoIspS able to cause invivo a dramatic change in total volatile emission from hemi- to monoterpenes and supporting evolution of isoprene synthases from ocimene synthases. The mechanism responsible for IspS neofunctionalization by active site size modulation by a single amino acid mutation demonstrated in this study might be general, as the very same amino acidic position is implicated in the parallel evolution of different short-chain terpene synthases from both angiosperms and gymnosperms. Based on these results, we present a model reconciling in a unified conceptual framework the apparently contrasting patterns previously observed for isoprene synthase evolution in plants. These results indicate that parallel evolution may be driven by relatively simple biophysical constraints, and illustrate the intimate molecular evolutionary links between the structural and functional bases of traits with global relevance.
The effects of heat transfer and Poisson's ratio on the compressive response of closed-cell polymer foams

The gas compression in closed-cell polymer foams was analysed, and the effect on the uniaxial compression stress-strain curve predicted. Transient heat conduction from the hot compressed gas to the cell walls occurs rapidly even in an impact, for the usual range of foam cell sizes. If the heat transfer is only by gas conduction, the predicted effect of cell size on the stress-strain curve is slightly too great, compared with experimental data. Hence there may be forced convection heat transfer in the deformed cells. For compression tests on a one minute time-scale, isothermal conditions prevail. As gas heating becomes significant, the strain hardening rate increases. The hysteresis due to heat transfer in an impact stress-strain curve is predicted to be a maximum for cells of 1 mm diameter. Poisson's ratio at high compressive strains was measured as 0.17 for low density polyethylene foam of density 23 kg m -3 , but less for higher densities. The larger the Poisson's ratio, the less is the gas compression contribution to strain hardening.