Miracle-dz/UniFAR-FTUs huggingface dataset:
Roles of Supernova Ejecta in Nucleosynthesis of the Light Elements Li, Be, and B

Explosions of Type Ic supernovae (SNe Ic) are investigated using a relativistic hydrodynamic code to study the role of their outermost layers of the ejecta in light-element nucleosynthesis through spallation reactions as a possible mechanism of the "primary" process. We have confirmed that the energy distribution of the outermost layers with a mass fraction of only 0.001% follows the empirical formula proposed by previous work when the explosion is furious. In such explosions, a significant fraction of the ejecta (>0.1% in mass) have energy greater than the threshold energy for spallation reactions. On the other hand, we find that the outermost layers of ejecta become more energetic than the empirical formula would predict when the explosion energy per unit ejecta mass is smaller than ~1.3 × 1051 ergs M. As a consequence, it is necessary to numerically calculate explosions to estimate light-element yields from SNe Ic. The usage of the empirical formula would overestimate the yields by a factor of ≳3 for energetic explosions, such as SN 1998bw, and underestimate the yields by a similar factor for less energetic explosions, such as SN 1994I. The yields of the light elements Li, Be, and B (LiBeB) from SNe Ic are estimated by solving the transfer equation of cosmic rays originated from ejecta of SNe Ic and compared with observations. The abundance ratios Be/O and B/O produced by each of our SNe Ic models are consistent with those of metal-poor stars. The total amounts of these elements estimated from observations indicate that energetic SNe Ic, such as SN 1998bw, could be candidates for a production site of Be and B in the Galactic halo only when the fraction of this type out of all the SNe was more than a factor of 100 higher than the value estimated from current observational data. This primary mechanism would predict that there are stars significantly deficient in light elements that were formed from the interstellar medium not affected by SNe Ic. Since this has no support from current observations, other primary mechanisms, such as the light-element formation in superbubbles, are needed for other types of SNe. The observed abundance pattern of all elements including heavy elements in metal-poor stars suggests that these two mechanisms should have supplied similar amounts of Be and B. Our calculations show that SNe Ic can not produce an appreciable amount of Li.
On User Choice in Graphical Password Schemes

Graphical password schemes have been proposed as an alternative to text passwords in applications that support graphics and mouse or stylus entry. In this paper we detail what is, to our knowledge, the largest published empirical evaluation of the effects of user choice on the security of graphical password schemes. We show that permitting user selection of passwords in two graphical password schemes, one based directly on an existing commercial product, can yield passwords with entropy far below the theoretical optimum and, in some cases, that are highly correlated with the race or gender of the user. For one scheme, this effect is so dramatic so as to render the scheme insecure. A conclusion of our work is that graphical password schemes of the type we study may generally require a different posture toward password selection than text passwords, where selection by the user remains the norm today.
Pulsed I-V and small signal characterisation and modelling of resonant tunneling diodes

This paper describes the use of dc pulses for current voltage (I-V) characterisation of resonant tunnelling diodes (RTDs). The results show that accurate (parasitic) oscillation-free measurements of the negative differential resistance (NDR) region can be done. The proposed technique allows for the monitoring of possible onset of parasitic oscillations during measurements, and so allows for specific measurement windows (when the device is stable) to be identified and so enable accurate measurements. Pulsed I-V experimental results of resonant tunnelling diodes are presented along with modelled I-V curves. In addition, the extraction of a small-signal equivalent circuit model for the RTD from the measured S-parameters (S11) is described.
Age Differences in Updating Working Memory: Evidence from the Delayed-Matching-To-Sample Test

The Delayed Matching-to-Sample (DMTS) Test was used in four experiments to test the hypothesis that older adults are less able than young to update the contents of working memory. Large age differences in working memory were found whenever there was a delay between presentation and test, and they did not vary as a function of delay length. Increasing the intertrial interval (ITI) reduced interference from the previous trial, but benefited old and young equally. In addition, although age differences in perceptual processing speed were correlated with reduced working memory, incomplete perception of the stimuli could not account for the findings. Together these results demonstrate age differences in updating working memory and the usefulness of the DMTS task to test hypotheses about the nature of these differences. Final discussion centers on the implications of these findings for the frontal lobe hypothesis of aging
Rethinking the Fear Circuit: The Central Nucleus of the Amygdala Is Required for the Acquisition, Consolidation, and Expression of Pavlovian Fear Conditioning

In the standard model of pavlovian fear learning, sensory input from neutral and aversive stimuli converge in the lateral nucleus of the amygdala (LA), in which alterations in synaptic transmission encode the association. During fear expression, the LA is thought to engage the central nucleus of the amygdala (CE), which serves as the principal output nucleus for the expression of conditioned fear responses. In the present study, we reexamined the roles of LA and CE. Specifically, we asked whether CE, like LA, might also be involved in fear learning and memory consolidation. Using functional inactivation methods, we first show that CE is involved not only in the expression but also the acquisition of fear conditioning. Next, we show that inhibition of protein synthesis in CE after training impairs fear memory consolidation. These findings indicate that CE is not only involved in fear expression but, like LA, is also involved in the learning and consolidation of pavlovian fear conditioning.
Prevalence of metabolic syndrome in pre- and post-menopausal women: A prospective study from apex institute of North India

Background: The metabolic syndrome (MS) (syndrome X, insulin resistance syndrome) is a constellation of metabolic abnormalities and a complex predisease state that predicts future development of type 2 diabetes mellitus and cardiovascular disease. Menopausal transition and postmenopausal state are considered as a vulnerable period for developing MS, and this increased risk has been attributed to decreasing estrogen levels with an increasing risk of insulin resistance following menopause. Aims and Objectives: This study aimed to determine the prevalence of MS and its components in pre- and post-menopausal women from North India. Methodology: This is a cross-sectional study of 350 women in the age group of 45-55 years attending gynecology clinic in a tertiary center of North India. Details of sociodemographic data, menopausal history, reproductive, and medical profile were obtained. Then, waist circumference, body mass index (BMI), and blood pressure were recorded. A venous blood sample was collected for fasting blood glucose, triglycerides, total cholesterol, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol. MS was defined according to the modified National Cholesterol Education Program Adult Treatment Panel III criteria. Results: The mean age was 49.09 ± 2.2 years in premenopausal and 49.54 ± 2.8 years in postmenopausal women. The prevalence of MS in the study group was 62.6%. Occurrence of MS was higher in older and obese women. Abnormal waist circumference was the most prevalent component (87%) of MS and in terms of odd ratio, correlation was highest for BMI followed by total cholesterol and waist-hip ratio. Conclusion: We should target obesity and deranged lipid profile by bringing out changes in lifestyle and dietary habits to decrease the higher prevalence of MS and the risk of cardiovascular diseases.
Characterization of the protective capacity and immunogenicity of the 69-kD outer membrane protein of Bordetella pertussis

Immunization with the 69-kD outer membrane protein (OMP) of Bordetella pertussis protected neonatal mice against lethal respiratory challenge with B. pertussis 18323. Active immunization elicited a serum IgG anti- 69-kD OMP response at the time of challenge, with IgG anti-69-kD OMP antibodies detected in bronchoalveolar lavage fluid after challenge. Intravenous administration of BPE8, a monoclonal IgG1 anti-69-kD OMP, also protected young mice against B. pertussis challenge. Intravenously injected BPE8 was detected in the lungs of mice at the time of aerosol challenge, suggesting that the presence of specific antibody in the lungs may mediate protection. Thus the 69-kD OMP of B. pertussis is a protective antigen in mice that elicits specific serum antibody that can transude to the lung. The 69-kD OMP was detected in a preparation of a Takeda acellular vaccine by immunoblot analysis and a serum antibody response to the 69-kD OMP was observed in 18-mo-old children boosted with this preparation of Japanese acellular vaccine. Our results demonstrate that the B. pertussis 69-kD OMP is a protective antigen in animals, is immunogenic in humans, and is present in a preparation of acellular pertussis vaccine that is widely used in Japan. These findings indicate that the 69-kD OMP should be seriously considered as a candidate for inclusion in new formulations of antigenically defined acellular pertussis vaccines.
Serum levels of retinol binding protein 4 in women with different levels of adiposity and glucose tolerance.

OBJECTIVE Retinol-binding protein 4 (RBP4) is an adipokine responsible for vitamin A (retinol) transportation. Studies associated RBP4 increased levels with severity of type 2 diabetes mellitus (T2DM) and insulin resistance (IR). The study aimed to quantify RBP4 serum standards in women with a wide range of body mass index (BMI) and glucose tolerance level. SUBJECTS AND METHODS Cross-sectional study was performed with 139 women divided into three groups: Group 1 (lean-control, n = 45) and Group 2 (obese, n = 53) with normal glucose tolerance and group 3 (obese with T2DM, n = 41), called G1, G2 and G3. Were assessed clinical, biochemical, anthropometric and body composition parameters. RESULTS According to data analysis, we obtained in G1 higher RBP4 levels (104.8 ± 76.8 ng/mL) when compared to G2 (87.9 ± 38 ng/mL) and G3 (72.2 ± 15.6 ng/mL) levels. Also, were found: in G1 positive correlations of RBP4 with BMI (r = 0.253), glycated hemoglobin (r = 0.378) and fasting insulin (r = 0.336); in G2 with glycated hemoglobin (r = 0.489); in G3 with glycated hemoglobin (r = 0.330), fasting glucose (r = 0.463), HOMA-IR (r = 0.481). CONCLUSIONS Although RBP4 have shown lower levels in diabetic and obese, a strong correlation with HOMA-IR index highlights that, in our study, there is growing IR when there is an increasing in RBP4 levels.
Implicit theories of courage

What is courage? This question garners significant interest and attention but little empirical research. An operational definition of courage is essential to good research, yet no consensus definition has fully emerged. This article systematically investigates people's conceptions of courage and courageous behavior through a series of studies employing well-grounded implicit methodologies. The organizational structure and components of courage are investigated using a response-generating task (Study 1) and alternate methods (Studies 2 and 3), followed by an experimental approach to determine if people actually use their implicit theories in their evaluations of others (Study 4). Collectively, these studies reveal an organizational structure of people's implicit theories of courage. Further, they indicate that people apply their implicit theories accurately in evaluating others. Then, Laches, suppose that we first set about determining the nature of courage … Tell me, if you can, what is courage Socrates (Plato, trans. 1987)
Give Everyone a Prize? Employee Stock Options in Private Venture-Backed Firms

This study examines employee stock options in private entrepreneurial companies. I focus on private U.S. venture-backed firms because they are renowned for the intensity and organizational depth of their stock option grants. Contrary to simple stereotype, however, I show that 27% of U.S. venture-backed firms do not grant stock options to all employees. I seek to explain this by theorizing that the economic and legal settings in which venture-backed companies exist lead to both costs and benefits from the use of stock options to attract, compensate, incent, monitor, and retain certain employees, and that sometimes the costs exceed the benefits. I test the theory by determining whether variation in the organizational depth to which venture-backed firms grant employee stock options can be explained by proxies for these economic and legal costs. Such proxies include the fraction of employees who are in technical positions; the degree of flatness in the firm's organizational structure; its proximity to other venture-backed companies; the number of patents it has been granted; and the fraction of equity held by venture investors. The results support the theory and thereby imply that venture-backed firms grant employee stock options in an economically sophisticated manner.
Accuracy of platelet counting haematology analysers in severe thrombocytopenia and potential impact on platelet transfusion

Although haematology analysers provide reliable full blood counts, they are known to be inaccurate at enumerating platelets in severe thrombocytopenia. If the thresholds for platelet transfusion, currently set at 10 × 109/l, are to be further reduced, it is vital that the limitations of current analysers are fully understood. The aim of this large multicentre study was to determine the accuracy of haematology analysers in current routine practice for platelet counts below 20 × 109/l. Platelet counts estimated by analysers using optical, impedance and immunological methods were compared with the International Reference Method for platelet counting. The results demonstrated variation in platelet counting between different analysers and even the same type of analyser at different sites. Optical methods for platelet counting on the XE 2100, Advia 120, Cell‐Dyn 4000 and H3* were not superior to impedance methods on the XE 2100, LH750 and Pentra analysers. All analysers except one overestimated the platelet count, which would result in under transfusion of platelets. This study highlights the inaccuracies of haematology analysers in platelet counting in severe thrombocytopenia. It re‐emphasizes the need for external quality control to improve analyser calibration for samples with low platelet counts, and suggests that the optimal thresholds for prophylactic platelet transfusions should be re‐evaluated.
International Journal of Science and Technology Determination of Dose Rate Levels around Nuclear Installations in Ghana

As part of a national survey to estimate ambient or background dose rate within the country, background dose rate evaluation was carried out around the only Nuclear Research Reactor, the Gamma Irradiation Facility and their environs on the premises of the Ghana Atomic Energy Commission. The work was performed using an AT6101C Spectrometer normally known as Backpack. It was identified at the end of work that the dose rate varied from 0.1410 ± 0. 042μSv/h to 0.2730 ± 0. 101μSv/h with an average value of 0.1979 ± 0.056 µSv/h. The work also revealed that the background dose at the Ghana Atomic Energy Commission is primarily from natural background implying that there is adequate shielding for all the radioactive sources present on its premises and there has possibly never been any significant contamination from the activities of the commission on its premises.
Reproductive factors for ovarian cancer in southern Chinese women

Objective To investigate the association between reproductive factors and the risk of ovarian cancer among southern Chinese women. Methods A hospital-based case-control study was undertaken in Guangzhou, Guangdong Province, between 2006 and 2008. A structured questionnaire was used to obtain information on parity, oral contraceptive use and other reproductive factors in a sample of 500 incident ovarian cancer patients and 500 controls (mean age, 59 years). Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using unconditional logistic regression models. Results High parity was inversely associated with ovarian cancer, with an adjusted OR 0.43 (95% CI, 0.30 to 0.62) for women who had given birth to 3 or more children compared to women who had given no more than one birth. Ever use of oral contraceptives was also protective against ovarian cancer; adjusted OR 0.56 (95% CI, 0.40 to 0.78). No association was found for hormone replacement therapy, menopausal status, hysterectomy and family history of ovarian and/or breast cancer. Conclusion High parity and oral contraceptive use are associated with a lower risk of ovarian cancer in southern Chinese women.
The Validity of the Teacher Perceiver Interview for Predicting Performance of Classroom Teachers

Research addressing the selection of teachers has focused largely on preemployment decisions of individuals as applicants and on preemployment decisions of school personnel as employers. Omitted from this research is any attention to postemployment outcomes associated with these preemployment decisions. To fill this void in current teacher selection research, we conducted a series of field studies assessing the relationship between preemployment responses of teacher candidates and postemployment outcomes using a predictive validity paradigm. Preemployment responses on a commercial interview protocol purported to predict future teacher performance are assessed relative to postemployment ratings of principals and to behavioral actions of newly hired teachers. Results indicate that a percentage of the systematic variance associated with postemployment performance is accounted for by preemployment responses to a standardized commercial interview protocol. These findings are cast within the larger body of teacher selection research through a model for teacher selection, and recommendations are provided for use of the commercial interview protocol in the field setting.
MR spectroscopy evaluation and short-term outcome of olfactory ensheathing cells transplantation in amyotrophic lateral sclerosis patients.

OBJECTIVE To evaluate proton MR spectroscopy (1H-MRS) for detection of the motor cortex and adjacent brain in amyotrophic lateral sclerosis (ALS) patients with apparent upper motor neuron involvement after olfactory ensheathing cells (OECs) transplantation. METHODS From December 2004 to February 2005, 7 patients with clinically definite ALS who could safely undergo MRS were admitted into the perspective study. The neurological status, ALS functional rating scale (ALSFRS), EMG, and 1H-MRS taken before and 2 weeks after operations were carefully analyzed. The NAA/Cr and Cho/Cr ratios were measured in the cerebral peduncle, genu and posterior limb of the internal capsule, corona radiata and precentral gyrus. RESULTS The ALSFRS in 2 cases improved obviously whose ALSFRS increased from 30 to 33 and from 29 to 34 respectively. And 5 cases remained stable 2 weeks after OECs transplantation. Statistical analyses for all seven cases showed both the NAA/Cr and Cho/Cr ratios decreased, but in the two cases with ALSFRS improvement the NAA/Cr increased in the certain anatomic position which confirmed the neurological and EMG findings. CONCLUSION The proton MR spectroscopy is a suitable noninvasive measure for ALS evaluation. The preliminary study suggests that two of the seven ALS cases improved apparently short-term after OECs transplantation. More patients are required for the clinical study and longer follow-up duration is needed for future research.
Manic-Depressive Illness: Bipolar Disorders and Recurrent Depression, 2nd ed

Iin this magnificent second edition, Drs. Frederick Goodwin and Kay Redfield Jamison bring their unique contribution to mental health science into the 21st century. In collaboration with a team of other leading scientists, a collaboration designed to preserve the unified voice of the two authors, they exhaustively review the biological and genetic literature that has dominated the field in recent years and incorporate cutting-edge research conducted since publication of the first edition. They also update their surveys of psychological and epidemiological evidence, as well as that pertaining to diagnostic issues, course, and outcome, and they offer practical guidelines for differential diagnosis and clinical management. The medical treatment of manic and depressive episodes is described, strategies for preventing future episodes are given in detail, and psychotherapeutic issues common in this illness are considered. Special emphasis is given to fostering compliance with medication regimens and treating patients who abuse drugs and alcohol or who pose a risk of suicide. This book, unique in the way that it retains the distinct perspective of its authors while assuring the maximum in-depth coverage of a vastly expanded base of scientific knowledge, will be a valuable and necessary addition to the libraries of psychiatrists and other physicians, psychologists, clinical social workers, neuroscientists, pharmacologists, and the patients and families who live with manic-depressive illness.
A Study of Web Services Performance Prediction: A Client's Perspective

The Web service (WS) paradigm is an emerging approach to building Web applications, in which software designers typically build new WSs by leveraging existing, third-party WSs. Understanding performance characteristics of third party WSs is critical to the overall system performance. Although such performance evaluation can be done through testing of third party WSs, it is quite an expensive process. This is especially the case when testing at high workloads, because performance degradations are likely to occur, which may render the WS under testing unusable during the tests¡¦ duration. Avoiding testing at high workloads by applying standard extrapolation approaches from data collected at low workloads (e.g., using regression analysis) results in a lack of accuracy. To address this challenge, in this paper, we propose a framework that utilizes the benefits of queueing models to guide the extrapolation process, while achieving accuracy in both regimes ¡V low and high workloads. Our extensive experiments show that our approach gives accurate results as compared to standard techniques (i.e., use of regression analysis alone).