Miracle-dz/UniFAR-FTUs huggingface dataset:
Evaluation of Macular Retinal Ganglion Cell-Inner Plexiform Layer Thickness after Vitrectomy with Internal Limiting Membrane Peeling for Idiopathic Macular Holes

Purpose. To evaluate macular retinal ganglion cell-inner plexiform layer (GCIPL) thickness changes after Brilliant Blue G-assisted internal limiting membrane peeling for idiopathic macular hole repair using a high-resolution spectral-domain optical coherence tomography (SD-OCT). Methods. 32 eyes from 32 patients with idiopathic macular holes who underwent vitrectomy with internal limiting membrane peeling between January 2011 and July 2012 were retrospectively analyzed. GCIPL thickness was measured before surgery, and at one month and at six months after surgery. Values obtained from automated and semimanual SD-OCT segmentation analysis were compared (Cirrus HD-OCT, Carl Zeiss Meditec, Dublin, CA). Results. No significant differences were found between average GCIPL thickness values between preoperative and postoperative analysis. However, statistical significant differences were found in GCIPL thickness at the temporal macular quadrants at six months after surgery. Quality measurement analysis performed by automated segmentation revealed a significant number of segmentation errors. Semimanual segmentation slightly improved the quality of the results. Conclusion. SD-OCT analysis of GCIPL thickness found a significant reduction at the temporal macular quadrants at 6 months after Brilliant Blue G-assisted internal limiting membrane peeling for idiopathic macular hole.
The appliance of science? New public management and strategic change

Abstract Changes in the nature of science as a social practice were fundamentally organic and endogenous in nature prior to the 1970s. Since then changes in UK public science has been policy-led and the imperatives exogenous. This shift was the result of attempts to achieve strategic managed change in the sector using new public management (NPM) techniques. This paper explores the discourses that promoted the change effort and the NPM techniques and processes deployed to this end. It seeks to identify the aims and objectives of the intended strategic change and evaluates the extent to which they have been achieved. Our conclusion is that rather than a planned, strategic change process directed at improved economy, efficiency and effectiveness, what occurred was a poorly processed ideologically driven attempt to achieve political aims.
Teachers’ Views of Students’ Mathematical Capabilities: Challenges and Possibilities for Ambitious Reform

Background Research suggests that teachers’ views of their students’ capabilities matter when attempting to accomplish instructional reform, particularly in settings serving historically marginalized groups of students. However, to date, this issue has received minimal attention in the scholarship and practice of mathematics instructional reform. Purpose This study offers a large-scale snapshot of middle-grades teachers’ views of their students’ mathematical capabilities in the context of instructional reform. It contributes to the field's understanding of the learning demands for teachers inherent in achieving a vision of high-quality mathematics instruction and suggests potentially critical foci for professional learning opportunities. Setting The study took place in two large urban districts pursuing ambitious reform in middle-grades mathematics. Participants Participants included 122 middle-grades mathematics teachers. Research Design The study consisted of a qualitative analysis of semistructured interviews conducted with each of 122 teachers regarding their perspectives on the district's reform efforts, including their views of their students’ mathematical capabilities in relation to the reform. Conceptually, we approached our analysis of teachers’ views of their students’ mathematical capabilities by attending to how they framed a common problem of practice—students facing difficulty in mathematics—diagnostically (i.e., how they explained the source of students’ difficulty) and prognostically (i.e., what they described doing to support students facing difficulty). Analysis also focused on patterns in the relations between teachers’ diagnostic and prognostic framings. Findings On the whole, most teachers did not view all of their students as capable of participating in rigorous mathematical activity. Most teachers attributed at least some of their students’ difficulty to inherent traits of the students or deficits in their families or communities, and most described lowering the cognitive demand of an activity if they perceived that students were facing difficulty. Moreover, our analysis of the relations between teachers’ diagnostic and prognostic framing revealed that even when teachers explained students’ difficulty in terms of instructional opportunities, thereby taking responsibility for their students’ learning, they did not necessarily respond in ways that would enable students to participate substantially in rigorous mathematical activity. Conclusions Findings suggest that a significant challenge in accomplishing ambitious reform entails supporting shifts in how teachers view their students’ capabilities along two dimensions: how teachers explain the source of students’ difficulties in mathematics and how they address such difficulties. Implications for designing professional learning opportunities to support productive shifts in teachers’ views of their students’ capabilities are discussed.
Partnership and Social Capital as the Resources for Pupils` Health and Well-Being in School Communities - A Follow-Up Study in Finland

The aim of this study was to investigate comprehensive (classes 1-9) school teachers' views of the functionality of the social support networks in promoting pupils' health and well-being in school communities. This study belongs to the European Network of Health Promoting Schools programme (ENHPS) evaluation project in Finland. In this study partnership and the social support networks between home and school, school nurse and school community and school community and various other networks are a part of social capital that promote pupils' health and well-being. The survey data were collected from teachers (N = 22) by the means of web-based questionnaires in the spring terms in a four-year follow-up design. The teachers felt that the social support network and partnership between school and parents and school nurses was significant in promoting the health and well-being of pupils. However, parents and school nurses didn't always have opportunities to participate in the planning and evaluation of teaching and health promotion work in the schools. In the future, partnership will represent a potential way in which schools might build additional capacities and support for promoting pupils' health and well-being. Furthermore, social capital is not separate from other capital structures, such as cultural and economic capital, which are all needed.
Chewing gum and a saliva substitute alleviate thirst and xerostomia in patients on haemodialysis.

BACKGROUND Most patients on haemodialysis (HD) have to maintain a fluid-restricted diet to prevent a high interdialytic weight gain (IWG). The prevalence of xerostomia (the feeling of a dry mouth) is higher in HD patients than in controls. Recently, we demonstrated that xerostomia and thirst were positively correlated with IWG in HD patients. Thus, this may play a role as a stimulus for fluid intake between dialysis sessions. The aim of the present study was to investigate the effect of chewing gum or a saliva substitute on xerostomia, thirst and IWG. METHODS This study was a randomized two-treatment crossover design with repeated measures. After the use of chewing gum or saliva substitute for 2 weeks, a wash-out period of 2 weeks was introduced and hereafter the other regimen was carried out. Xerostomia and thirst were assessed by validated questionnaires as xerostomia inventory (XI) and dialysis thirst inventory (DTI), at baseline and after each treatment period, as were IWG and salivary flow rates. RESULTS Sixty-five HD patients (42 men, 54.6+/-14.1 years; 23 women, 54.7+/-16.3 years) participated in this study. Chewing gum decreased XI from 29.9+/-9.5 to 28.1+/-9.1 (P<0.05). Chewing gum as well as a saliva substitute reduced DTI significantly (P<0.05), but no differences occurred for the average IWG or salivary flow rates. CONCLUSIONS The use of chewing gum and, to a lesser extent, a saliva substitute may alleviate thirst and xerostomia in some HD patients.
Consensus with convergence rate in directed networks with multiple non-differentiable input delays

This paper investigates consensus problems in directed networks of multi-agent systems considering multiple and non-differentiable time-varying delays. A transformation is carried out to convert the consensus problem into an analysis of stability. Then, a novel Lyapunov-Krasovskii functional (LKF) is employed to prove consensus with an estimate for the exponential convergence rate in terms of a set of Linear Matrix Inequalities (LMIs). Numerical simulations are provided to show the effectiveness of the proposed method. Comparisons with similar approaches are also presented.
CR Singular Immersions of Complex Projective Spaces

Quadratically parametrized smooth maps from one complex projective space to another are constructed as projections of the Segre map of the complexifi- cation. A classification theorem relates equivalence classes of projections to congru- ence classes of matrix pencils. Maps from the 2-sphere to the complex projective plane, which generalize stereographic projection, and immersions of the complex projective plane in four and five complex dimensions, are considered in detail. Of particular interest are the CR singular points in the image.
Joining Chain–Expressing and–Nonexpressing B Cell Populations in the Mouse

The diphtheria toxin A chain (DTA) was gene targeted into the Joining chain (J chain) locus to create a mouse strain selecting against J chain–expressing cells, JDTA mice. Serum immunoglobulin (Ig)M and serum IgG were reduced six to eightfold, while serum IgA was elevated 14-fold in these mice. JDTA mice were immune competent although the serum Ig response compared with wild-type mice was reduced sixfold at day 14 but only fourfold at day 45 after immunization. Exchanging the DTA gene with a cDNA for c-myc resulted in mice with a distinct phenotype with increased Ig production and enhanced humoral immune responses. Analysis of single B cells stimulated by lipopolysaccharide in vitro using reverse transcription–polymerase chain reaction showed that J chain–nonexpressing B cells could be detected that had a secretory phenotype as determined by an abundance of transcript for secretory IgM. Finally, limiting dilution analysis of peripheral B cells showed that J chain expression was a clonal property already established in naive, peripheral B lymphocytes.
Forest soil disturbance intervals inferred from soil charcoal radiocarbon dates

Forest soil disturbance intervals are usually too long to measure using plot-based studies, and thus they are poorly understood. The mean soil disturbance interval (MSDI) in an old-growth forest on the west coast of Vancouver Island was estimated from radiocarbon dates of charcoal from organic and mineral soil horizons. Two assumptions are required to estimate the MSDI: (1) charcoal from forest fires is deposited within the organic horizon and eventually mixed into deeper mineral horizons by soil disturbances, and (2) the probability of soil disturbance is spatially homogeneous and affected only by the time since the last fire or the last soil disturbance. The MSDI is then estimated by the rate at which the proportion of undisturbed sample sites (determined by the proportion of sites with charcoal from the most recent fire in the organic horizon) decreases with increasing time since the last fire. Soil charcoal evidence of time since fire was determined at 83 sites using 141 radiocarbon dates. The estimat.
An Online Static Index Pruning Algorithm

Static index pruning can significantly reduce index size and query processing time. An online static index pruning algorithm is presented, which is a term-centric method and adopts BM25 weighting as the pruning measure. The algorithm scans through documents set with one pass and directly builds pruned index, and therefore avoids the construction of original index. The experiments based on TREC data set show that the online static index pruning algorithm requires less time to build pruned index, and the pruning effectiveness outperforms the baseline method.
Liquidity Constraints and Investment in Transition Economies: The Case of Bulgaria

The authors use firm level data on Bulgaria to investigate the impact of liquidity constraints on firms' investment performance. Internal funds are a important determinant of investment in most industrial economies. The authors use a simple accelerator model of investment to test whether liquidity constraints are relevant in Bulgaria's case. Their estimates are based on data for 1993-95, before Bulgaria's financial crisis of 1996-97. It turns out that Bulgarian firms are liquidity-constrained and that firms' size and financial structure help to distinguish between firms that are more and less liquidity-constrained. In the authors' view, liquidity constraints in transition economies should be interpreted in different ways than those in industrial economies. In Bulgaria, liquidity constraints, and hence access to external funds should be seen in the context of soft budget constraints and the financial system's failure to enforce the efficient allocation of funds. The relationship between liquidity constraints and firm characteristics may actually be the opposite of what is normally the case in industrial countries. In Bulgaria, lack of liquidity constraints may be a sign of financial weakness.
A Pilot Study of IL-2Rα Blockade during Lymphopenia Depletes Regulatory T-cells and Correlates with Enhanced Immunity in Patients with Glioblastoma

Background Preclinical studies in mice have demonstrated that the prophylactic depletion of immunosuppressive regulatory T-cells (TRegs) through targeting the high affinity interleukin-2 (IL-2) receptor (IL-2Rα/CD25) can enhance anti-tumor immunotherapy. However, therapeutic approaches are complicated by the inadvertent inhibition of IL-2Rα expressing anti-tumor effector T-cells. Objective To determine if changes in the cytokine milieu during lymphopenia may engender differential signaling requirements that would enable unarmed anti-IL-2Rα monoclonal antibody (MAbs) to selectively deplete TRegs while permitting vaccine-stimulated immune responses. Methodology A randomized placebo-controlled pilot study was undertaken to examine the ability of the anti-IL-2Rα MAb daclizumab, given at the time of epidermal growth factor receptor variant III (EGFRvIII) targeted peptide vaccination, to safely and selectively deplete TRegs in patients with glioblastoma (GBM) treated with lymphodepleting temozolomide (TMZ). Results and Conclusions Daclizumab treatment (n = 3) was well-tolerated with no symptoms of autoimmune toxicity and resulted in a significant reduction in the frequency of circulating CD4+Foxp3+ TRegs in comparison to saline controls (n = 3)( p = 0.0464). A significant (p<0.0001) inverse correlation between the frequency of TRegs and the level of EGFRvIII specific humoral responses suggests the depletion of TRegs may be linked to increased vaccine-stimulated humoral immunity. These data suggest this approach deserves further study. Trial Registration ClinicalTrials.gov NCT00626015
Compact models of motor primitive variations for predictable reaching and obstacle avoidance

In most activities of daily living, related tasks are encountered over and over again. This regularity allows humans and robots to reuse existing solutions for known recurring tasks. We expect that reusing a set of standard solutions to solve similar tasks will facilitate the design and on-line adaptation of the control systems of robots operating in human environments. In this paper, we derive a set of standard solutions for reaching behavior from human motion data. We also derive stereotypical reaching trajectories for variations of the task, in which obstacles are present. These stereotypical trajectories are then compactly represented with Dynamic Movement Primitives. On the humanoid robot Sarcos CB, this approach leads to reproducible, predictable, and human-like reaching motions.
The TGFBI R555W mutation induces a new granular corneal dystrophy type I phenotype

Purpose To report the clinical and molecular features of a distinct form of transforming growth factor-β-induced (TGFBI) gene-linked corneal dystrophy exhibiting a new granular corneal dystrophy type I (CDGG1) phenotype. Methods A complete ophthalmologic examination was performed in all individuals of a Chinese family in which autosomal dominant transmission of the disease had been observed. DNA was obtained from the peripheral blood leukocytes of each participating subject. Genetic analyses included keratin 3 (KRT3), keratin 12 (KRT12), and TGFBI polymerase chain reaction (PCR) amplification and automated nucleotide sequencing of exons from the genomic DNA. Results The corneal phenotype in this pedigree was characterized by multiple bilateral dot-like, circular opacities at different corneal depths, with some of the affected individuals only having opacities in the epithelium, which is different from the typical CDGG1 phenotype. TGFBI analysis revealed a heterozygous point mutation at exon 12 (c.1663C>T) in all of the affected individuals, predicting a p.R555W missense mutation. Conclusions The phenotype which resulted from the TGFBI R555W mutation in this family is distinct from that observed in the typical case of CDGG1. We propose this disorder should be classified as a new phenotype of CDGG1, and this finding demonstrates the importance of gene diagnosis in the corneal dystrophies.
Investigation of Relationships among Excavate Taxa Using a New Quartet-Based Phylogenetic Analysis Method

An interesting group called excavates is considered as one of the keys to understand early eukaryotic evolution. Excavates include jakobids, malawimonas, trimastix, carpediemonas, diplomonads, retortamonas, and heterolobosea. Other relatives have been associated because of their relationship to one or more core-excavate taxa. These relatives include Oxymonads, Parabasalids, and Euglenozoa. Many relationships among excavate taxa and their relatives are uncertain. We present a phylogenetic analysis of the excavate taxa and their relatives using our newly developed quartet-based method (QBNJ). We also demonstrate how molecular phylogenetic methods and morphological evidences can be effectively incorporated into the tree reconstruction. We found that some clusters are robust and independent of the methods used. However, at some point during the merge process there are critical points where more than one possible merge could be possible for the same species/subtree. More reliable results could be obtained by combining morphological and molecular phylogenetic analyses.
Noninvasive measurement of rat intraocular pressure with the Tono-Pen.

PURPOSE The purpose of this study was to evaluate the Tono-Pen 2 tonometer for measuring intraocular pressure (IOP) in the living rat eye. METHODS One eye from each of 20 adult, anesthetized brown Norway rats (group 1) was cannulated and simultaneously connected to a syringe and a pressure transducer with a chart recorder. We increased IOP from 15 to 45 mmHg in 5-mmHg increments and obtained 15 consecutive readings (ignoring instrument-generated averages) at each pressure increment with a Tono-Pen 2 tonometer. To test the tonopen's ability to measure unknown IOP, transducer pressures were varied randomly in 20 additional animals (group 2), and tonopen readings were obtained in masked fashion. RESULTS Plotting the mean tonopen readings for each animal against transducer IOP produced a regression formula of y = 4.54 + 0.79x (r = 0.98). Mean group 2 tonopen values plotted against transducer IOP yielded a regression formula of y = 4.75 + 0.78x (r = 0.94). A method comparison analysis showed that the tonopen significantly overestimates pressures at low IOP (< or = 15 mmHg), and it significantly underestimates pressures at high IOP (> or = 30 mmHg). Using two-way analysis of variance, it was determined that the group 2 data did not differ significantly from the group 1 data (P > or = 0.76). Because of this consistency, we generated a correction factor with 95% prediction intervals for Tono-Pen readings. CONCLUSIONS The Tono-Pen 2 can be used reliably to measure IOP in the normal rat eye.
A Three-Dimensional Spatiotemporal Receptive Field Model Explains Responses of Area MT Neurons to Naturalistic Movies

Area MT has been an important target for studies of motion processing. However, previous neurophysiological studies of MT have used simple stimuli that do not contain many of the motion signals that occur during natural vision. In this study we sought to determine whether views of area MT neurons developed using simple stimuli can account for MT responses under more naturalistic conditions. We recorded responses from macaque area MT neurons during stimulation with naturalistic movies. We then used a quantitative modeling framework to discover which specific mechanisms best predict neuronal responses under these challenging conditions. We find that the simplest model that accurately predicts responses of MT neurons consists of a bank of V1-like filters, each followed by a compressive nonlinearity, a divisive nonlinearity, and linear pooling. Inspection of the fit models shows that the excitatory receptive fields of MT neurons tend to lie on a single plane within the three-dimensional spatiotemporal frequency domain, and suppressive receptive fields lie off this plane. However, most excitatory receptive fields form a partial ring in the plane and avoid low temporal frequencies. This receptive field organization ensures that most MT neurons are tuned for velocity but do not tend to respond to ambiguous static textures that are aligned with the direction of motion. In sum, MT responses to naturalistic movies are largely consistent with predictions based on simple stimuli. However, models fit using naturalistic stimuli reveal several novel properties of MT receptive fields that had not been shown in prior experiments.
Word sense disambiguation in information retrieval revisited

Word sense ambiguity is recognized as having a detrimental effect on the precision of information retrieval systems in general and web search systems in particular, due to the sparse nature of the queries involved. Despite continued research into the application of automated word sense disambiguation, the question remains as to whether less than 90% accurate automated word sense disambiguation can lead to improvements in retrieval effectiveness. In this study we explore the development and subsequent evaluation of a statistical word sense disambiguation system which demonstrates increased precision from a sense based vector space retrieval model over traditional TF*IDF techniques.