Miracle-dz/UniFAR-FTUs huggingface dataset:
Randomized phase III study of cisplatin with or without raltitrexed in patients with malignant pleural mesothelioma: an intergroup study of the European Organisation for Research and Treatment of Cancer Lung Cancer Group and the National Cancer Institute of Canada.

PURPOSE We conducted a phase III trial to determine whether first-line treatment with raltitrexed, a thymidine synthase inhibitor, and cisplatin results in superior outcome compared with cisplatin alone in patients with malignant pleural mesothelioma (MPM). PATIENTS AND METHODS Eligible patients with histologically proven advanced MPM, not pretreated with chemotherapy, WHO performance status (PS) 0 to 2, and adequate hematological, renal, and hepatic function were randomly assigned to receive cisplatin 80 mg/m2 IV on day 1, alone (arm A) or combined with raltitrexed 3 mg/m2 (arm B). In patients with measurable disease, response was monitored using the Response Evaluation Criteria in Solid Tumors criteria. Health related quality of life (HRQOL) was measured using the European Organisation for Research and Treatment of Cancer QLQ-C30 and Lung Module (QLQ-LC13). RESULTS Two hundred fifty patients were randomized: 80% male; median age, 58 years; and WHO PS, 0, 1, 2 in 25, 62, and 13% of cases, respectively. There were no toxic deaths. The main grade 3 or 4 toxicities observed were neutropenia and emesis, reported twice as often in the combination arm. Among 213 patients with measurable disease, response rate was 13.6% (arm A) versus 23.6% (arm B; P = .056). No difference in HRQOL was observed on any of the scales. Median overall and 1-year survival in arms A and B were 8.8 (95% CI, 7.8 to 10.8) v 11.4 months (95% CI, 10.1 to 15), respectively, and 40% v 46%, respectively (P = .048). CONCLUSION A combination of raltitrexed and cisplatin improves overall survival compared with cisplatin alone. This study confirms that a combination of cisplatin and an antifolate is superior to cisplatin alone in patients with MPM, without harmful effect on HRQOL.
Defining the Interactions and Role of DCAF1/VPRBP in the DDB1-Cullin4A E3 Ubiquitin Ligase Complex Engaged by HIV-1 Vpr to Induce a G2 Cell Cycle Arrest

HIV viral protein R (Vpr) induces a cell cycle arrest at the G2/M phase by activating the ATR DNA damage/replication stress signalling pathway through engagement of the DDB1-CUL4A-DCAF1 E3 ubiquitin ligase via a direct binding to the substrate specificity receptor DCAF1. Since no high resolution structures of the DDB1-DCAF1-Vpr substrate recognition module currently exist, we used a mutagenesis approach to better define motifs in DCAF1 that are crucial for Vpr and DDB1 binding. Herein, we show that the minimal domain of DCAF1 that retained the ability to bind Vpr and DDB1 was mapped to residues 1041 to 1393 (DCAF1 WD). Mutagenic analyses identified an α-helical H-box motif and F/YxxF/Y motifs located in the N-terminal domain of DCAF1 WD that are involved in exclusive binding to DDB1. While we could not identify elements specifically involved in Vpr binding, overall, the mutagenesis data suggest that the predicted β-propeller conformation of DCAF1 is likely to be critical for Vpr association. Importantly, we provide evidence that binding of Vpr to DCAF1 appears to modulate the formation of a DDB1/DCAF1 complex. Lastly, we show that expression of DCAF1 WD in the absence of endogenous DCAF1 was not sufficient to enable Vpr-mediated G2 arrest activity. Overall, our results reveal that Vpr and DDB1 binding on DCAF1 can be genetically separated and further suggest that DCAF1 contains determinants in addition to the Vpr and DDB1 minimal binding domain, which are required for Vpr to enable the induction of a G2 arrest.
Assessment of solvent capsule-based healing for woven E-glass fibre-reinforced polymers

Vacuum Assisted Resin Infusion Molding (VARIM) with low vacuum pressure difference was used to manufacture woven glass fibre-reinforced epoxy resin plates, with a fibre volume fraction of approx. 50 vol% and containing ethyl phenylacetate (EPA)-filled capsules for self-healing purposes. Capsules were introduced by functionalising the fabrics through manual dispersion. We investigated the capability of autonomously healing delaminations induced by static loading in Mode I and II. Healing did not take place for composite samples; this was attributed to the presence of bare fibres on the crack plane and to the reduction of EPA diffusion into the matrix in the presence of fibres both of which hinder the swelling mechanism responsible for healing the cracks.
Stateless model checking of event-driven applications

Modern event-driven applications, such as, web pages and mobile apps, rely on asynchrony to ensure smooth end-user experience. Unfortunately, even though these applications are executed by a single event-loop thread, they can still exhibit nondeterministic behaviors depending on the execution order of interfering asynchronous events. As in classic shared-memory concurrency, this nondeterminism makes it challenging to discover errors that manifest only in specific schedules of events. In this work we propose the first stateless model checker for event-driven applications, called R4. Our algorithm systematically explores the nondeterminism in the application and concisely exposes its overall effect, which is useful for bug discovery. The algorithm builds on a combination of three key insights: (i) a dynamic partial order reduction (DPOR) technique for reducing the search space, tailored to the domain of event-driven applications, (ii) conflict-reversal bounding based on a hypothesis that most errors occur with a small number of event reorderings, and (iii) approximate replay of event sequences, which is critical for separating harmless from harmful nondeterminism. We instantiate R4 for the domain of client-side web applications and use it to analyze event interference in a number of real-world programs. The experimental results indicate that the precision and overall exploration capabilities of our system significantly exceed that of existing techniques.
Chelation Effects on Azotobacter Cells and Cysts

Goldschmidt, Millicent C. (University of Texas, Austin), and Orville Wyss. Chelation effects on Azotobacter cells and cysts. J. Bacteriol. 91:120–124. 1966. —Ethylenediaminetetraacetate (EDTA) is very toxic to Azotobacter in the presence of nitrogen compounds that form complexes with it. This appears to be due to stronger chelation of certain metal ions by the complex. When such complexes of EDTA and nitrogen compound are absent, Azotobacter cysts can be ruptured by chelation without being killed. The lethal action as well as the cyst rupture is modified by the presence of salts.
Examination of chemosensory functions in patients with dysosmia

Summary Background To examine changes of chemical sensory functions in patients with dysosmia. Material/Methods The 272 study subjects included 98 healthy volunteers, 86 subjects with hyposmia and 88 subjects with functional anosmia. Their chemical sensory functions were examined using olfactory event-related potentials (oERPs), trigeminal event-related potentials (tERPs), T&T olfactometer and triple drop method, respectively. Results The T&T results showed that the difference between patients and healthy subjects had statistical significance. The oERPs and tERPs results showed that patients with functional anosmia had N1 and P2 waves of prolonged latency and reduced amplitude when compared to healthy subjects with the difference of statistical significance. When compared to healthy subjects, patients with functional anosmia had clear hypogeusia and the difference had statistical significance. For the younger group there was significant difference between healthy subjects and patients in T&T, oERPs and tERPs results. Conclusions It is suggested by the apparently concomitant trigeminal nerve dysfunction and hypogeusia in patients with functional anosmia in this study that olfactory and nasal trigeminal function in young patients was clearly decreased. Our study suggests the possible application of oERPs, tERPs and three drops method in clinical diagnosis in Chinese populations and provides scientific evidence for treatment.
Comparative Study on the Nutritional Value of Pidan and Salted Duck Egg

Pidan and salted duck eggs are of nutritional rich alternative duck egg products which are predominantly consumed in China, Thailand, South Korea and other Chinese migrated countries. Both eggs are rich in proteins, lipids, unsaturated fatty acids and minerals. A Pidan whole egg contains 13.1% of protein, 10.7% of fat, 2.25% of carbohydrate and 2.3% of ash, whereas the salted duck egg contains 14% of protein, 16.6% of fat, 4.1% of carbohydrate and 7.5% of ash. The fresh duck egg contains a range of 9.30-11.80% of protein, 11.40-13.52% of fat, 1.50-1.74% of sugar and 1.10-1.17% of ash. Proteins, lipids, and ash contents are found to be greatly enhanced during the pickling and salting process of pidan and salted duck eggs. However, the alkaline induced aggregation of pidan leads to degradation and subsequent generation of free peptides and amino acids. Very few amino acids are found to be lost during the pickling and storage. However, no such losses of amino acids are reported in salted duck eggs during the salting process of 14 d. Phospholipids and cholesterol contents are lower in pidan oil and salted duck egg yolk oil. Thus, the pidan and salted duck eggs are nutritionally rich alternatives of duck egg products which will benefit the human health during consumption.
Working memory capacity and fluid abilities : Examining the correlation between Operation Span and

The correlation between a measure of working memory capacity (WMC) (Operation Span) and a measure of fluid abilities (Raven Advanced Progressive Matrices) was examined. Specifically, performance on Raven problems was decomposed by difficulty, memory load, and rule type. The results suggest that the relation between Operation Span and Raven is fairly constant across levels of difficulty, memory load, and rule type. Thus, it appears something other than the number of things that can be held memory is important for the shared variance between these two tasks. The results are discussed in terms of the importance of attention control as a possible link between working memory capacity and fluid abilities. D 2004 Elsevier Inc. All rights reserved.
Left Ventricular Remodeling in Transgenic Mice With Cardiac Restricted Overexpression of Tumor Necrosis Factor

Background—The mechanisms responsible for tumor necrosis factor (TNF)–induced LV structural remodeling in the adult heart are not known. Methods and Results—We generated a line of transgenic mice (MHCsTNF) with cardiac restricted overexpression of TNF that develop progressive LV dilation/remodeling from 4 to 12 weeks of age. During the early phases of LV structural remodeling, there was a significant increase in total matrix metalloproteinase (MMP) activity that corresponded to a decrease in total myocardial fibrillar collagen content. As the MHCsTNF mice aged, there was a significant decrease in total MMP zymographic activity that was accompanied by an increase in total fibrillar collagen content. The changes in total MMP activity and myocardial fibrillar collagen content were related to a time- dependent increase in myocardial tissue inhibitor of metalloproteinases (TIMP)-1 levels, resulting in a significant time-dependent decrease in the MMP activity/TIMP level ratio in the MHCsTNF mice. To determine a possible mechanism for the increase in myocardial fibrosis, we also measured levels of TGF-&bgr;1 and TGF-&bgr;2 protein levels, which were shown to be significantly elevated in the hearts of the MHCsTNF mice. Conclusions—Our results suggest that progressive time-dependent changes in the balance between MMP activity and TIMP activity are responsible, at least in part, for the spectrum of TNF-induced changes in the myofibrillar collagen content that occur during LV structural remodeling in the MHCsTNF mice.
This Paper Is Included in the Proceedings of the 11th Usenix Symposium on Networked Systems Design and Implementation (nsdi '14). Bringing Gesture Recognition to All Devices Bringing Gesture Recognition to All Devices Co-primary Student Authors

Existing gesture-recognition systems consume significant power and computational resources that limit how they may be used in low-end devices. We introduce AllSee, the first gesture-recognition system that can operate on a range of computing devices including those with no batteries. AllSee consumes three to four orders of magnitude lower power than state-of-the-art systems and can enable always-on gesture recognition for smartphones and tablets. It extracts gesture information from existing wireless signals (e.g., TV transmissions), but does not incur the power and computational overheads of prior wireless approaches. We build AllSee prototypes that can recognize gestures on RFID tags and power-harvesting sensors. We also integrate our hardware with an off-the-shelf Nexus S phone and demonstrate gesture recognition in through-the-pocket scenarios. Our results show that AllSee achieves classification accuracies as high as 97% over a set of eight gestures.
Monitoring of DNA Damage in Individuals Exposed to Petroleum Hydrocarbons in Ecuador

Currently, it is known that several chemical agents used or generated by the oil industry are classified as mutagens and/or carcinogens. Among these we have gasoline, diesel, butane gas, styrene, benzene, chloroform, and others. Studies have verified that these chemicals have effects in fertility (abortions, sterility); produce various upheavals, such as dizziness, nausea, muscular pain; and produce chromosomal damage at the DNA level, which in the long or medium run, can develop into cancer and leukemia. The genetic damage in exposed individuals was measured by means of the comet test, chromosomal alterations test, and the study of the CYP 1A1 and MSH2 genes. These methods were applied to determine the genotoxicity of hydrocarbons and their residue in human beings. When conducting these tests on the blood samples of individuals exposed to hydrocarbons (workers of oil companies) and of a control population of the area of study and Quito, it was found that, in effect, the exposed individuals presented a greater amount of damage at the DNA level as well as at the chromosomal level than the individuals from the control populations (P< 0.001). Thus, it can be determined that populations that are exposed to hydrocarbons are susceptible to developing genetic damage. Therefore, risk groups can be determined in certain zones where the oil impact has been greater.
The RNA-Binding Protein NANOS2 Is Required to Maintain Murine Spermatogonial Stem Cells

Maintaining Germline Stem Cells Spermatogonial stem cell pools in postnatal testes have to be maintained to continuously generate spermatozoa. It has been difficult to identify these stem cells in vivo, because of their small numbers and lack of appropriate molecular markers, but now Sada et al. (p. 1394) show that the RNA-binding protein NANOS2 is expressed in a small subset of spermatogonia that behave as self-renewing stem cells in intact testes. By a combinatorial use of loss- and gain-of-function studies, NANOS2 was found to be essential for the maintenance of the immature state of spermatogonial stem cells by supporting their self-renewing properties and by suppressing differentiation. Cell lineage tracing reveals the factor that preserves stem cells in the undifferentiated state in the mouse male germ line. Stem cells give rise to differentiated cell types but also preserve their undifferentiated state through cell self-renewal. With the use of transgenic mice, we found that the RNA-binding protein NANOS2 is essential for maintaining spermatogonial stem cells. Lineage-tracing analyses revealed that undifferentiated spermatogonia expressing Nanos2 self-renew and generate the entire spermatogenic cell lineage. Conditional disruption of postnatal Nanos2 depleted spermatogonial stem cell reserves, whereas mouse testes in which Nanos2 had been overexpressed accumulated spermatogonia with undifferentiated, stem cell–like properties. Thus, NANOS2 is a key stem cell regulator that is expressed in self-renewing spermatogonial stem cells and maintains the stem cell state during murine spermatogenesis.
3C-SiC — From Electronic to MEMS Devices

Since decades, silicon carbide (SiC) has been avowed as an interesting material for highpower and high-temperature applications because of its significant properties including its wide bandgap energy and high temperature stability. SiC is also professed as an ideal candidate for microsystem applications due to its excellent mechanical properties and chemical inertia, making it suitable for harsh environments. Among the 250 different SiC polytypes, only 4H, 6H and 3C-SiC are commercially available. The cubic structure, 3C-SiC, is the only one that can be grown on cheap silicon substrates. Hence, 3C-SiC is more interesting than any other polytype for reducing fabrication costs and increasing wafer diameter. This huge property has been evidenced for more than 30 years using chemical vapor deposition. Despite this key achievement and the growing interest for silicon carbide, no 3C-SiC-based devices can be found on the market whereas 4H-SiCbased devices are more and more largely commercialized. Even so, important headways have been reached for electrical and microelectromechanical systems (MEMS) applica‐ tions. Therefore, the purpose of this chapter is to address concerns related to electronic applications and MEMS fabrication of 3C-SiC-based devices, trying to give a broad overview on specific issues and challenging solutions.
MRI Risk Stratification for Tumor Relapse in Rectal Cancer Achieving Pathological Complete Remission after Neoadjuvant Chemoradiation Therapy and Curative Resection

PURPOSE Rectal cancer patients achieving pCR are known to have an excellent prognosis, yet no widely accepted consensus on risk stratification and post-operative management (e.g., adjuvant therapy) has been established. This study aimed to identify magnetic resonance imaging (MRI) high-risk factors for tumor relapse in pathological complete remission (pCR) achieved by rectal cancer patients who have undergone neoadjuvant concurrent chemoradiation therapy (CRT) and curative resection. MATERIALS AND METHODS We analyzed 88 (male/female = 55/33, median age, 59.5 years [range 34-78]) pCR-proven rectal cancer patients who had undergone pre-CRT MRI, CRT, post-CRT MRI and curative surgery between July 2005 and December 2012. Patients were observed for post-operative tumor relapse. We analyzed the pre/post-CRT MRIs for parameters including mrT stage, mesorectal fascia (mrMRF) status, tumor volume, tumor regression grade (mrTRG), nodal status (mrN), and extramural vessel invasion (mrEMVI). We performed univariate analysis and Kaplan-Meier survival analysis. RESULTS Post-operative tumor relapse occurred in seven patients (8.0%, n = 7/88) between 5.7 and 50.7 (median 16.8) months. No significant relevance was observed between tumor volume, volume reduction rate, mrTRG, mrT, or mrN status. Meanwhile, positive mrMRF (Ppre-CRT = 0.018, Ppre/post-CRT = 0.006) and mrEMVI (Ppre-CRT = 0.026, Ppre-/post-CRT = 0.008) were associated with higher incidence of post-operative tumor relapse. Kaplan-Meier survival analysis revealed a higher risk of tumor relapse in patients with positive mrMRF (Ppre-CRT = 0.029, Ppre-/post-CRT = 0.009) or mrEMVI (Ppre-CRT = 0.024, Ppre-/post-CRT = 0.003). CONCLUSION Positive mrMRF and mrEMVI status was associated with a higher risk of post-operative tumor relapse of pCR achieved by rectal cancer patients, and therefore, can be applied for risk stratification and to individualize treatment plans.
Application of phosphite in a high-volume foliar spray delays and reduces the rate of mortality of four Banksia species infected with Phytophthora cinnamomi

There were two experiments in which three phosphite concentrations were sprayed onto the foliage of either Banksia brownii, B. baxteri or B. coccinea naturally infected with Phytophthora cinnamomi in the Esperance Plains bioregion of Western Australia, or B. grandis artificially infected with P. cinnamomi in Eucalyptus marginata forest of south-western Australia. Plots were either sprayed with one of three concentrations of phosphite (2.5, 5 or 10 g phosphite/L) and penetrant-spreading agent or sprayed only with penetrant-spreading agent. Mortality of the Banksia species, understorey and crown health, plant height and soil inoculum at each site were the dependent variables. There were no significant differences in overstorey phytotoxic necrosis rating of B. brownii, B. baxteri and B. coccinea between phosphite treatments 2.7 and 4 years after the first spray. The greatest phytotoxic effect of phosphite application was the stunting of B. coccinea growth, which did not occur in B. brownii, B. baxteri and B. grandis. For naturally infested Banksia species, greatest mortality occurred in B. brownii and least in B. coccinea, with B. baxteri being intermediate between mortality for B. brownii and B. coccinea. There was a significant reduction in apparent mortality rate and increase in years to 50% mortality following foliar application of phosphite to the four Banksia species. Greatest reduction in mortality of the Banksia species occurred for concentrations between 5–10 g phosphite/L. Challenge inoculation showed that spray treatments of 5 g and 10 g of phosphite/L were effective in B. grandis, 2.2 years after spray. The proportion of positive P. cinnamomi soil samples from the top 3 cm of soil was significantly greater than the proportion positive from 30 cm below the soil surface in infested B. brownii and B. coccinea, but there was no significant difference in the proportion of positive P. cinnamomi soil samples between depth of sampling for B. baxteri. Phosphite had no significant effect on the frequency of isolation of P. cinnamomi from the soil of infested B. baxteri and B. coccinea. Determination of phosphite effectiveness against P. cinnamomi and phytotoxic responses between plant species will assist prescription optimisation for the most effective protection of threatened flora.
Neuroanatomical Dissociation of Encoding Processes Related to Priming and Explicit Memory

Priming is a facilitation of cognitive processing with stimulus repetition that can occur without explicit memory. Whereas the functional neuroanatomy of perceptual priming at retrieval is established, encoding processes that initiate priming and explicit memory have not yet been anatomically separated, and we investigated them using event-related functional magnetic resonance imaging. Activations predicting later explicit memory occurred in the bilateral medial temporal lobe (MTL) and left prefrontal cortex (PFC). Activity predicting later priming did not occur in these areas, but rather in the bilateral extrastriate cortex, left fusiform gyrus, and bilateral inferior PFC, areas linked with stimulus identification. Surprisingly, these regions showed response reductions. Our results demonstrate that priming and explicit memory have distinct functional neuroanatomies at encoding, with MTL activations being specific for explicit memory, and suggest that priming is initiated by sharpness of neural responding in stimulus identification areas, consistent with recent electrophysiological evidence regarding priming-related neural oscillations at encoding. We tentatively suggest that this sharpened responding at encoding may set the stage for increased neural processing efficiency at retrieval, with these different neural mechanisms both leading to observed priming-related hemodynamic decreases, and argue that neural measurements at encoding, and not just at retrieval, will be critical in resolving the debate about the neural mechanisms of learning that underlie priming.