Miracle-dz/UniFAR-FTUs huggingface dataset:
Cotranslational endoplasmic reticulum assembly of FcɛRI controls the formation of functional IgE-binding receptors

The human high affinity receptor for IgE (FcepsilonRI) is a cell surface structure critical for the pathology of allergic reactions. Human FcepsilonRI is expressed as a tetramer (alphabetagamma(2)) on basophils or mast cells and as trimeric (alphagamma(2)) complex on antigen-presenting cells. Expression of the human alpha subunit can be down-regulated by a splice variant of FcepsilonRIbeta (beta(var)). We demonstrate that FcepsilonRIalpha is the core subunit with which the other subunits assemble strictly cotranslationally. In addition to alphabetagamma(2) and alphagamma(2), we demonstrate the presence of alphabeta and alphabeta(var)gamma(2) complexes that are stable in the detergent Brij 96. The role of individual FcepsilonRI subunits for the formation of functional, immunoglobulin E-binding FcepsilonRI complexes during endoplasmic reticulum (ER) assembly can be defined as follows: beta and gamma support ER insertion, signal peptide cleavage and proper N-glycosylation of alpha, whereas beta(var) allows accumulation of alpha protein backbone. We show that assembly of FcepsilonRI in the ER is a key step for the regulation of surface expression of FcepsilonRI. The ER quality control system thus regulates the quantity of functional FcepsilonRI, which in turn controls onset and persistence of allergic reactions.
Assessing Alternative Perspectives on Race and Sex Employment Segregation

Four major explanations for employment segregation—skill deficits, worker preferences, economic and organizational structure, and stereotyping/queuing—are assessed using a diverse and overlapping set of predictors: general skills and training, product market structure, race- and sex-typed tasks and conditions, desirable employment and growth rates, and links to other labor market actors. A two-stage measurement and analytic strategy controls for relevant worker-level factors. Data from the 1990 census PUMs are analyzed to measure the employment segregation of black women, black men, and white women in relation to white men across 1,917 labor market positions, net of human capital, family structure, geographic residence and labor supply. Archival data provide measures of variables characterizing labor market positions. Stereotyping and queuing explanations are broadly consistent with nearly all results, while a worker preference approach applies to somewhat fewer predictors and is largely but not wholly compatible with their effects. A skill deficits explanation applies to, and is supported by, a narrow set of findings, while the economic and organizational structure explanations are restricted in their relevance and receive limited support.
Invasive aortic pulse wave velocity as a marker for arterial stiffness predicts outcome of renal sympathetic denervation.

AIMS A recurrent finding of trials on renal sympathetic denervation is a certain percentage of non-responders. The aim of this study was to examine the influence of arterial stiffness to predict response. METHODS AND RESULTS Eighty-eight patients were included in the study. Arterial stiffness was measured by invasive pulse wave velocity. Antihypertensive medication had to be unchanged during follow-up. Ambulatory blood pressure measurement (ABPM) was used to record blood pressure before and six months after denervation. Fifty-eight patients without changes in medication were included in the final analysis. Responders (n=37; blood pressure reduction -12.8±6.4 mmHg) had a significantly lower pulse wave velocity (14.4±4.4 m/s versus 17.7±4.5 m/s; p=0.009) compared to non-responders (n=21; blood pressure reduction +3.0±4.5 mmHg; p<0.001 for comparison with responders). In multivariate analysis, invasive pulse wave velocity was the only significant predictor of blood pressure reduction after denervation (odds ratio 1.15, 95% confidence interval [CI] 1.014-1.327; p=0.03). Patients with increased stiffness were older (p=0.001), had a higher prevalence of diabetes (p=0.008), more often had isolated systolic hypertension (p=0.007), and had a higher invasive pulse pressure (p<0.001). CONCLUSIONS Patients with lower pulse wave velocity showed a significantly better response to denervation. These findings emphasise that pulse wave velocity might be used as a selection criterion for renal denervation.
Uncovering the Intellectual Core of the Information Systems Discipline

What is the intellectual core of the information systems discipline? This study uses latent semantic analysis to examine a large body of published IS research in order to address this question. Specifically, the abstracts of all research papers over the time period from 1985 through 2006 published in three top IS research journals-MIS Quarterly, Information Systems Research, and Journal of Management Information Systems-were analyzed. This analysis identified five core research areas: (1) information technology and organizations; (2) IS development; (3) IT and individuals; (4) IT and markets; and (5) IT and groups. Over the time frame of our analysis, these core topics have remained quite stable. However, the specific research themes within each core area have evolved significantly, reflecting research that has focused less on technology development and more on the social context in which information technologies are designed and used. As such, this analysis demonstrates that the information systems academic discipline has maintained a relatively stable research identity that focuses on how IT systems are developed and how individuals, groups, organizations, and markets interact with IT.
Group heterogeneity and faultlines: Comparing alignment and dispersion theories of group composition

This field study examines group diversity from two theoretical viewpoints: dispersion approach (heterogeneity) and alignment approach (faultlines). We argue that the alignment approach provides an additional explanatory tool to that of the dispersion approach in understanding the effects of group composition on process and outcomes. Data from 60 work groups show that whereas groups with strong faultlines had higher levels of intragroup conflict and lower levels of performance and satisfaction, groups that were heterogeneous in tenure and functional background had higher levels of performance. Task conflict and process conflict mediated the relationship between faultlines and satisfaction. Our findings suggest that whereas both views of diversity contribute to our understanding of the relationship among 57 This research was supported by the SEI Center for Advanced Studies in Management of the Wharton School and the George Harvey Program on Redefining Diversity: Value Creation through Diversity. We are very grateful to Elaine Zanutto for the guidance in statistical analysis and to Madhan Gounder, Hina A. Kharbey, Isaac O. Choi, Andre Kursancew, and Poonam Maharjan for the assistance in data analysis. 03_BehfarCh03. qxd 6/14/07 2:13 AM Page 57
A Double-Deck Elevator Group Supervisory Control System Using Genetic Network Programming

Elevator group supervisory control systems (EGSCSs) are designed so that the movement of several elevators in a building is controlled efficiently. The efficient control of EGSCSs using conventional control methods is very difficult due to its complexity, so it is becoming popular to introduce artificial intelligence (AI) technologies into EGSCSs in recent years. As a new approach, a graph-based evolutionary method named genetic network programming (GNP) has been applied to the EGSCSs, and its effectiveness is clarified. The GNP can introduce various a priori knowledge of the EGSCSs in its node functions easily, and can execute an efficient rule-based group supervisory control that is optimized in an evolutionary way. Meanwhile, double-deck elevator systems (DDESs) where two cages are connected in a shaft have been developed for the rising demand of more efficient transport of passengers in high-rise buildings. The DDESs have specific features due to the connection of cages and the need for comfortable riding; so its group supervisory control becomes more complex and requires more efficient group control systems than the conventional single-deck elevator systems (SDESs). In this paper, a new group supervisory control system for DDESs using GNP is proposed, and its optimization and performance evaluation are done through simulations. First, optimization of the GNP for DDSEs is executed. Second, the performance of the proposed method is evaluated by comparison with conventional methods, and the obtained control rules in GNP are studied. Finally, the reduction of space requirements compared with SDESs is confirmed.
Aldosterone secretion and primary and malignant hypertension.

After the synthesis of desoxycorticosterone (DOC), it became apparent that this corticosteroid, the physiological effects of which are concerned primarily with sodium and potassium metabolism, can produce a state of hypertension both in animals and in man (1, 2). The induced hypertension is dependent upon the administration of adequate amounts of dietary sodium, whereas the hypertensive state, produced by administration of glucocorticoids such as cortisone, differs in that it is independent of the dietary sodium content (3). More recently, following the chemical and biological characterization of the mineralocorticoid hormone, aldosterone (4), a disease state associated with primary hypersecretion of this hormone has been described in man (5). Aldosterone produces effects on sodium and potassium metabolism similar to those of desoxycorticosterone, and the clinical syndrome of primary aldosteronism resembles the disease state produced by chronic administration of DOCto dogs (6). Arterial hypertension has been a consistent finding in patients with primary hyperaldosteronism. A number of other observations have suggested a relationship between the dietary sodium intake and the blood pressure level of patients with primary (benign essential) hypertension. The beneficial effects of sodium deprivation, and of various natriuretic agents in certain patients with hypertension, is well known. In addition, other studies have suggested that abnormalities of intracellular sodium and potassium content may occur in patients with arterial hypertension (7). Genest, Koiw, Nowaczynski and Lebouef (8) have re-
Reading a Smiling Face: Messages Conveyed by Various Forms of Smiling

This study investigated the effect of various forms of smiling (closed smile, upper smile, or broad smile) on person perception. Brazilian undergraduates (N = 330) judged a photograph of a male or female stimulus person in three age ranges (young, middle-aged, and old) and smiling or not. 7–point scales were used to measure respondents' perception of the stimulus persons on various attributes (attractiveness, happiness, extroversion, sympathy, kindness, submission, ambition, and intelligence). We found that a smile enhanced attractiveness and kindness ratings independently of its form, whereas the influence of the various forms on ratings of happiness was additive. As the neutral face changed to a closed smile and the closed smile became a broad smile, target stimuli were attributed greater rated happiness. We also found a contribution of perceivers' gender to the judgements of extroversion and sympathy, indicating a slightly greater discrimination of facial expressions among women than among men.
Analytical models for crosstalk excitation and propagation in VLSI circuits

The authors develop a general methodology to analyze crosstalk effects that are likely to cause errors in deep submicron high-speed circuits. They focus on crosstalk due to capacitive coupling between a pair of lines. Closed form equations are derived that quantify the severity of these effects and describe qualitatively the dependence of these effects on the values of circuit parameters, the rise/fall times of the input transitions, and the skew between the transitions. For noise propagation, they present a new way for predicting the output waveform produced by an inverter due to a nonsquare wave pulse at its input. To expedite the computation of the response of a logic gate to an input pulse, the authors have developed a novel way of modeling such gates by an equivalent inverter. The results of their analysis provide conditions that must be satisfied by a sequence of vectors used for validation of designs as well as post-manufacturing testing of devices in the presence of significant crosstalk. They present data to demonstrate accuracy of their results, including example runs of a test generator that uses these results.
Technological Implementation Fabry–Pérot Cavity in ${\rm Ti}{:}{\rm LiNbO}_{3}$ Waveguide by FIB

The realization of a Fabry-Pérot (F-P) cavity based on a Ti:LiNbO3 optical waveguide obtained by using a concept which consists of milling the Bragg gratings (BGs) in the cavity by the focused ion beam technique is shown in this letter. This F-P cavity is formed by two BGs which represent the two reflecting mirrors of the interferometer. The length of the cavity is defined by the distance between the two BGs. Thirty-one peaks and a free spectral range (FSR)=1.75 nm have been experimentally obtained in the range of wavelengths [1505-1548] nm. The experimental results are in accordance with those of theory. The fabrication process, the experimental results, as well as improvements to increase finesse F and FSR are discussed.
Rigor and Relevance: The Application of The Critical Incident Technique to Investigate Email Usage

Information systems research is often criticized for its high rigor, but low relevance. One approach to overcome the low relevance issue is to employ sound qualitative methods, out of which this study focuses on the critical incident technique (CIT) that has mostly been overlooked in IS research. The primary goal of this study is to demonstrate and validate the usage of the critical incident technique in the management information systems domain. The secondary objective is to develop a number of practical recommendations for email service providers and to offer novel theoretical insights that may be employed in future research. To this end, 107 positive and 113 negative critical incidents pertaining to email usage were collected and analyzed through classical content analysis techniques. Overall, this investigation validates the usage of the CIT in the MIS field and presents practical and theoretical recommendations.
Closed‐Chain Rehabilitation for Upper and Lower Extremities

&NA; Closed‐chain exercise protocols are used extensively in rehabilitation of knee injuries and are increasingly used in rehabilitation of shoulder injuries. They are felt to be preferable to other exercise programs in that they simulate normal physiologic and biomechanical functions, create little shear stress across injured or healing joints, and reproduce proprioceptive stimuli. Because of these advantages, they may be used early in rehabilitation and have been integral parts of “accelerated” rehabilitation programs. The authors review the important components of a closed‐chain rehabilitation program and provide examples of specific exercises that are used for rehabilitation of knee and shoulder injuries.
Recent Developments and Future Trends in Volunteered Geographic Information Research: The Case of OpenStreetMap

User-generated content (UGC) platforms on the Internet have experienced a steep increase in data contributions in recent years. The ubiquitous usage of location-enabled devices, such as smartphones, allows contributors to share their geographic information on a number of selected online portals. The collected information is oftentimes referred to as volunteered geographic information (VGI). One of the most utilized, analyzed and cited VGI-platforms, with an increasing popularity over the past few years, is OpenStreetMap (OSM), whose main goal it is to create a freely available geographic database of the world. This paper presents a comprehensive overview of the latest developments in VGI research, focusing on its collaboratively collected geodata and corresponding contributor patterns. Additionally, trends in the realm of OSM research are discussed, highlighting which aspects need to be investigated more closely in the near future.
International Capital Mobility in African Countries : A Panel Cointegration Analysis

This paper investigates the Feldstein-Horioka coefficients for 37 African countries using the recently developed Pool Mean Group (PMG), Fully Modified OLS (FMOLS) and Dynamic OLS (DOLS) panel cointegration techniques. The empirical findings reported in the paper reveal that savings and investment are nonstationary and cointegrated series. The estimated coefficients using FMOLS, DOLS and PMG are 0.38, 0.58 and 0.36, respectively for the sample as a whole for the period 1970-2006. These results confirm the previous studies that capital was relatively mobile in African countries. In addition, our study shows that there are marked differences in saving-retention coefficients for different country groups in Africa (Franc CFA zone countries and non Franc CFA zone countries; oil producing and non-oil producing countries; civil law and common law countries).
Lecture capture: student hopes, instructor fears

Technology to capture and retransmit lectures has been widely available for more than two decades. However, the widespread expectation that universities will record all lectures is not matched by systematic research and theory on lecture capture use. This paper provides a brief overview of research and reports a three-phase study of lecture video use and perceptions carried out with the staff and students of an undergraduate psychology program at a large suburban university. We found that some lecturers are concerned that mandatory lecture capture creates copyright problems and reduces their ability to provide their best teaching. There is also evidence that lecture capture decreases attendance and lowers grades for some students. However, our results indicate that for students enrolled in face-to-face units, the availability of captured lecture videos offers a valuable revision tool which is integrated into “traditional” study patterns rather than replacing them.
The Ages and Stages Questionnaire and Neurodevelopmental Impairment in Two-Year-Old Preterm-Born Children

Objective To test the ability of the Ages and Stages Questionnaire, Third Edition (ASQ3) to help identify or exclude neurodevelopmental impairment (NDI) in very preterm-born children at the corrected age of two. Methods We studied the test results of 224 children, born at <32 postmenstrual weeks, who had scores on ASQ3 and Bayley Scales of Infant and Toddler Development, Third Edition (BSIDIII) and neurological examination at 22–26 months’ corrected age. We defined NDI as a score of <70 on the cognitive—or motor composite scale of BSIDIII, or impairment on neurological examination or audiovisual screening. We compared NDI with abnormal ASQ3 scores, i.e., < -2SDs on any domain, and with ASQ3 total scores. To correct for possible overestimation of BSIDIII, we also analyzed the adjusted BSIDIII thresholds for NDI, i.e., scores <80 and <85. Results We found 61 (27%) children with abnormal ASQ3 scores, and 10 (4.5%) children who had NDI with original BSIDIII thresholds (<70). Twelve children had NDI at BSIDIII thresholds at <80, and 15 had <85. None of the 163 (73%) children who passed ASQ3 had NDI. The sensitivity of ASQ3 to detect NDI was excellent (100%), its specificity was acceptable (76%), and its negative predictive value (NPV) was 100%. Sensitivity and NPV remained high with the adjusted BSIDIII thresholds. Conclusion The Ages and Stages Questionnaire is a simple, valid and cost-effective screening tool to help identify and exclude NDI in very preterm-born children at the corrected age of two years.
New Evidence on Religious Pluralism, Urbanism, and Religious Participation

In a recent issue of ASR, Finke and Stark (1988) reported results that contradict long-standing views on the relationship between religious pluralism, urbanism, and religious participation. They argue that religious pluralism and urbanism are positively related to religious participation. The present paper disputes the generality of Finke and Stark's findings with both methodological criticisms and new data. With regard to pluralism, although the traditional views are supported, a new theoretical interpretation is introduced and empirically supported: religious pluralism appears to have differential effects on religious participation, depending on the religious makeup of the religious community along a liberal-to-conservative continuum. Finally, the best evidence suggests that there probably is not an important rural-urban difference in the rate of church adherents today.
The effect of athletic participation on the academic achievement of high school students

Athletic participation is a major component of the high school experience for many students across the country, yet in difficult economic times athletic funding is often the first area reduced when education budgets need to be balanced. These cuts are usually performed without data on or inquiry into the relationship between athletic participation and academic achievement. If a relationship could be proven, advocates of athletics would have a stronger argument for the preservation of funding. This study utilized a quantitative, causal-comparative design to examine the relationship between athletic participation and academic achievement. Grade point averages of students who participated in high school athletics three years in a row were compared with those of students who did not participate for three years in a row. The study focused on the growth rate, or change in grade point average over the three years, in order to make a stronger argument that differences in achievement between the two groups could be attributed to participation (or lack of participation). On average, the achievement of athletes was significantly higher than that of non-participants during the first year, but athletes lost some of this advantage over the course of the study, meaning that they experienced negative growth. Non-participants did experience positive growth that was statistically significant, however the effect size was small, meaning that the practical significance is minimal. Based on the results of the study, it is difficult to make the argument that athletics are linked to improved academic achievement. While athletic participation can still be considered part of the overall education of students with numerous benefits such as the development of leadership and teamwork skills, these benefits do not seem to translate to the classroom. Because the practical significance is low, there are no recommendations based on the results of this study in relation to funding or policy changes, although school districts may want to consider making the funding of activities