Miracle-dz/UniFAR-FTUs huggingface dataset:
Social-cognitive conceptualization of attachment working models : Availability and accessibility effects

Attachment working models were conceptualized from the perspective of current social-cognitive theory. In Studies l and 2, most people reported experience with multiple styles of relating; at the same time, the general attachment style they endorsed was related to (a) the percentage of their significant relationships fitting different attachment-style descriptions, (b) the ease with which they could generate exemplar relationships matching these descriptions, and (c) their interpersonal expectations in these relationships. In Study 3, priming different types of attachment experiences affected participants' attraction to potential dating partners who displayed particular attachment orientations. These findings suggest that most people possess relational schemas corresponding to a range of attachment orientations and that the relative availability and accessibility of this knowledge determine their thinking about relationships.
Lightning Sensors for Observing, Tracking and Nowcasting Severe Weather

Severe and extreme weather is a major natural hazard all over the world, often resulting in major natural disasters such as hail storms, tornados, wind storms, flash floods, forest fires and lightning damages. While precipitation, wind, hail, tornados, turbulence, etc. can only be observed at close distances, lightning activity in these damaging storms can be monitored at all spatial scales, from local (using very high frequency [VHF] sensors), to regional (using very low frequency [VLF] sensors), and even global scales (using extremely low frequency [ELF] sensors). Using sensors that detect the radio waves emitted by each lightning discharge, it is now possible to observe and track continuously distant thunderstorms using ground networks of sensors. In addition to the number of lightning discharges, these sensors can also provide information on lightning characteristics such as the ratio between intra-cloud and cloud-to-ground lightning, the polarity of the lightning discharge, peak currents, charge removal, etc. It has been shown that changes in some of these lightning characteristics during thunderstorms are often related to changes in the severity of the storms. In this paper different lightning observing systems are described, and a few examples are provided showing how lightning may be used to monitor storm hazards around the globe, while also providing the possibility of supplying short term forecasts, called nowcasting.
Biophysical investigation of GpIbalpha binding to thrombin anion binding exosite II.

Substrates and cofactors of the serine protease thrombin (IIa) employ two anion binding exosites (ABE-I and -II) to aid in binding. On the surface of platelets resides the GpIbalpha/beta-GpIX-GpV membrane-bound receptor complex. IIa's ABE-II is proposed to interact with an anionic portion of GpIbalpha which enhances IIa cleavage of PAR-1 and subsequent activation of platelets. In this work, one-dimensional (1D) and two-dimensional (2D) NMR, analytical ultracentrifugation (AUC), and hydrogen-deuterium exchange (HDX) coupled with MALDI-TOF MS were performed to further characterize the features of binding to IIa's ABEs. The described work builds upon investigations performed in a prior study with fibrin(ogen)'s gamma' peptide and IIa [Sabo, T. M. , Farrell, D. H. , and Maurer, M. C. (2006) Biochemistry 45, 7434-7445]. 1D line broadening NMR (1H and 31P) and 2D trNOESY NMR studies indicate that GpIbalpha residues D274-E285 interact extensively with the IIa surface in an extended conformation. AUC demonstrates that both GpIbalpha (269-286) and gamma' (410-427) peptides interact with IIa with a 1:1 stoichiometry. When the HDX results are compared to those for the ABE-I targeting peptide hirudin (54-65), the data imply that GpIbalpha (269-286), GpIbalpha (1-290), and gamma' (410-427) are indeed directed to ABE-II. The ABE-II binding fragments reduce HDX for sites distant from the interface, suggesting long-range conformational effects. These studies illustrate that GpIbalpha and gamma' target ABE-II with similar consequences on IIa dynamics, albeit with differing structural features.
Ferromagnetism of ZnO and GaN: A Review

AbstractThe observation of ferromagnetism in magnetic ion doped II–VI diluted magnetic semiconductors (DMSs) and oxides, and later in (Ga,Mn)As materials has inspired a great deal of research interest in a field dubbed “spintronics” of late, which could pave the way to exploit spin in addition to charge in semiconductor devices. The main challenge for practical application of the DMS materials is the attainment of a Curie temperature at or preferably above room temperature to be compatible with junction temperatures. Among the studies of transition-metal doped conventional III–V and II–VI semiconductors, transition-metal-doped ZnO and GaN became the most extensively studied topical materials since the prediction by Dietl et al., based on mean field theory, as promising candidates to realize a diluted magnetic material with Curie temperature above room temperature. The underlying assumptions, however, such as transition metal concentrations in excess of 5% and hole concentrations of about 1020 cm−3, have not gotten as much attention. The particular predictions are predicated on the assumption that hole mediated exchange interaction is responsible for magnetic ordering. Among the additional advantages of ZnO-and GaN-based DMSs are that they can be readily incorporated in the existing semiconductor heterostructure systems, where a number of optical and electronic devices have been realized, thus allowing the exploration of the underlying physics and applications based on previously unavailable combinations of quantum structures and magnetism in semiconductors. This review focuses primarily on the recent progress in the theoretical and experimental studies of ZnO- and GaN-based DMSs. One of the desirable outcomes is to obtain carrier mediated magnetism, so that the magnetic properties can be manipulated by charge control, for example through external electrical voltage. We shall first describe the basic theories forwarded for the mechanisms producing ferromagnetic behavior in DMS materials, and then review the theoretical results dealing with ZnO and GaN. The rest of the review is devoted to the structural, optical, and magnetic properties of ZnO- and GaN-based DMS materials reported in the literature. A critical review of the question concerning the origin of ferromagnetism in diluted magnetic semiconductors is given. In a similar vein, limitations and problems for identifying novel ferromagnetic DMS are briefly discussed, followed by challenges and a few examples of potential devices.
Optogenetic Evidence for a Direct Circuit Linking Nociceptive Transmission through the Parabrachial Complex with Pain-Modulating Neurons of the Rostral Ventromedial Medulla (RVM)

Abstract The parabrachial complex (PB) is a functionally and anatomically complex structure involved in a range of homeostatic and sensory functions, including nociceptive transmission. There is also evidence that PB can engage descending pain-modulating systems, the best characterized of which is the rostral ventromedial medulla (RVM). Two distinct classes of RVM neurons, “ON-cells” and “OFF-cells,” exert net pronociceptive and anti-nociceptive effects, respectively. PB was recently shown to be a relay of nociceptive information to RVM ON- and OFF-cells. The present experiments used optogenetic methods in a lightly anesthetized rat and an adult RVM slice to determine whether there are direct, functionally relevant inputs to RVM pain-modulating neurons from PB. Whole-cell patch-clamp recordings demonstrated that PB conveys direct glutamatergic and GABAergic inputs to RVM neurons. Consistent with this, in vivo recording showed that nociceptive-evoked responses of ON- and OFF-cells were suppressed by optogenetic inactivation of archaerhodopsin (ArchT)-expressing PB terminals in RVM, demonstrating that a net inhibitory input to OFF-cells and net excitatory input to ON-cells are engaged by acute noxious stimulation. Further, the majority of ON- and OFF-cells responded to optogenetic activation of channelrhodopsin (ChR2)-expressing terminals in the RVM, confirming a direct PB influence on RVM pain-modulating neurons. These data show that a direct connection from the PB to the RVM conveys nociceptive information to the pain-modulating neurons of RVM under basal conditions. They also reveal additional inputs from PB with the capacity to activate both classes of RVM pain-modulating neurons and the potential to be recruited under different physiological and pathophysiological conditions.
Alcohol use and protective sexual behaviors among high-risk adolescents.

OBJECTIVE This study seeks to advance our understanding of moderating influences on the relationship between alcohol and condom use by examining their association at both the global and event levels of analysis using a prospective approach within a sample of high-risk adolescents. The following potential moderators were examined: sex-related alcohol expectancies, gender, relationship type, level of alcohol use, and impulsive sensation seeking. METHOD Criminally involved adolescents (N = 300) completed measures of alcohol use, condom use, personality, and alcohol expectancies; 267 (89%) participants completed a behavioral assessment 6 months later. RESULTS At the global level of analysis, there was a significant moderating effect of alcohol-related sexual-enhancement expectancies, such that the relationship between alcohol and condom use was negative and significant only among individuals with higher sexual-enhancement expectancies. At the time-limited global level, impulsive sensation seeking at baseline was negatively associated with condom use at 6-month follow-up. At the event level, there was a Gender x Alcohol interaction such that alcohol use was unrelated to condom use among males but was strongly and negatively related among females. CONCLUSIONS This study makes a contribution to the understanding of the relationship between alcohol use and condom use by looking beyond main effects and conducting an empirically driven and multilevel examination of moderating variables. Results support the inclusion of situation-specific alcohol risk-reduction content in human immunodeficiency virus/sexually transmitted disease-prevention activities.
The Healthcare-Seeking Behaviour of Schizophrenic Patients in Cambodia

Aims: To understand the patterns of the schizophrenic patients' healthcare-seeking behaviour (HCSB) in the context of a post-conflict country where psychiatric facilities are scarce. Methods: Cross-sectional survey assessing schizophrenic patients and their caregivers who consulted for the first time in four different outpatient psychiatric departments. Results: One hundred and four schizophrenic patients were selected: 56.7% began the HCSB with traditional medicine; 22.1% with western medicine, psychiatry included, and 20.2% with religious medicine; 77.3% did not begin the HCSB with psychiatry because they did not know it was a mental problem or because they did not know mental health services existed. The patients' education was the only factor that significantly influenced the HCSB. Conclusion: In Cambodia, traditional and religious medicine are the first pathway to mental healthcare when patient and caregiver decide to seek help due to psychotic symptoms. The lack of knowledge on mental health and facilities appears the main reason to explain the schizophrenic patients' HCSB. This suggests that the development of psychiatry in Cambodia will be facilitated by a better spreading of knowledge on mental health and will have to take traditional and religious medicine into account.
Topical preparations for pain relief: efficacy and patient adherence

There has been an increasing focus on development of new routes of drug administration to provide tailored treatments for patients, without decreasing efficacy of analgesia, in proportion to the progression of the knowledge of pain mechanisms. While acute pain acts as an alarm, chronic pain is a syndrome requiring meticulous selection of analgesic drugs of high bioavailability for long-term use. Such criteria are challenges that topical medications aim to overcome, allowing progressive delivery of active component, maintaining stable plasma levels, with a good safety profile. This review presents recent findings regarding topical formulations of the most widely used drugs for pain treatment, such as nonsteroidal anti-inflammatory agents, anesthetics, and capsaicin, and the role of physical agents as delivery enhancers (phonophoresis and iontophoresis). Although the number of topical agents is limited for use in peripheral conditions, increasing evidence supports the efficacy of these preparations in blocking nociceptive and neuropathic pain. Patient adherence to medical treatment is also a challenge, especially in chronic painful conditions. It is known that reduction of treatment complexity and pill burden are good strategies to increase patient compliance, as discussed here. However, the role of topical presentations, when compared to traditional routes, has not yet been fully explored and thus remains unclear.
Three-Dimensional Cellular Neural Networks and Pattern Generation Problems

This work investigates three-dimensional pattern generation problems and their applications to three-dimensional Cellular Neural Networks (3DCNN). An ordering matrix for the set of all local patterns is established to derive a recursive formula for the ordering matrix of a larger finite lattice. For a given admissible set of local patterns, the transition matrix is defined and the recursive formula of high order transition matrix is presented. Then, the spatial entropy is obtained by computing the maximum eigenvalues of a sequence of transition matrices. The connecting operators are used to verify the positivity of the spatial entropy, which is important in determining the complexity of the set of admissible global patterns. The results are useful in studying a set of global stationary solutions in various Lattice Dynamical Systems and Cellular Neural Networks.
stdchk: A Checkpoint Storage System for Desktop Grid Computing

Checkpointing is an indispensable technique to provide fault tolerance for long-running high-throughput applications like those running on desktop grids. This article argues that a checkpoint storage system, optimized to operate in these environments, can offer multiple benefits: reduce the load on a traditional file system, offer high-performance through specialization, and, finally, optimize data management by taking into account checkpoint application semantics. Such a storage system can present a unifying abstraction to checkpoint operations, while hiding the fact that there are no dedicated resources to store the checkpoint data. We prototype stdchk, a checkpoint storage system that uses scavenged disk space from participating desktops to build a low-cost storage system, offering a traditional file system interface for easy integration with applications. This article presents the stdchk architecture, key performance optimizations, and its support for incremental checkpointing and increased data availability. Our evaluation confirms that the stdchk approach is viable in a desktop grid setting and offers a low cost storage system with desirable performance characteristics: high write throughput as well as reduced storage space and network effort to save checkpoint images.
Prostatic ductal system in rats: regional variation in morphological and functional activities.

The rat prostate is a complex ductal system with branches and subbranches extending from one end to another. Owing to the relative distance of various regions of the duct from the urethra, the entire length of the ductal system can be arbitrarily divided into three segments, i.e., the proximal, intermediate, and distal segments. The present study was carried out to assess the regional variation in cellular activities in this ductal system. Ventral prostates from adult Sprague-Dawley rats were dissected so that an individual ductal system was mechanically isolated and longitudinally sectioned to reveal various segments. Epithelial cells lining distal segments were tall-columnar type and were actively engaging in mitotic activity. Cells in intermediate segments were also tall-columnar type. However, they were mitotically quiescent, but able to produce secretory proteins. Evidence of programmed cell death was not observed in either of these two segments. Cells in proximal segments, on the other hand, were low-columnar or cuboidal in shape and were stained heavily for cathepsin D, a marker associated with late manifestation of cell death. Following castration in adult rats, there was a reversal in the site of programmed death in cells lining the ductal system. By Day 4 post-castration, distal segments contained many epithelial cells with intense cytoplasmic staining for cathepsin D while proximal segments showed a reduction in number of positively stained cells. By Day 7 post-castration, cells in proximal segments, though atrophied, were devoid of staining for cathepsin D. (ABSTRACT TRUNCATED AT 250 WORDS)
Critical Use of Balloon Angioplasty after Recanalization Failure with Retrievable Stent in Acute Cerebral Artery Occlusion

Objective Sudden major cerebral artery occlusion often resists recanalization with currently available techniques or can results in massive symptomatic intracranial hemorrhage (sICH) after thrombolytic therapy. The purpose of this study was to examine mechanical recanalization with a retrievable self-expanding stent and balloon in acute intracranial artery occlusions. Methods Twenty-eight consecutive patients with acute intracranial artery occlusions were treated with a Solitaire retrievable stent. Balloon angioplasty was added if successful recanalization was not achieved after stent retrieval. The angiographic outcome was assessed by Thrombolysis in Cerebral Infarction (TICI) and the clinical outcomes were assessed by the National Institutes of Health Stroke Scale (NIHSS) and the modified Rankin Scale (mRS). Results At baseline, mean age was 69.4 years and mean initial NIHSS score was 12.5. A recanalization to TICI 2 or 3 was achieved in 24 patients (85%) after stent retrieval. Successful recanalization was achieved after additional balloon angioplasty in 4 patients. At 90-day follow-up, 24 patients (85%) had a NIHSS improvement of ≥4 and 17 patients (60%) had a good outcome (mRS ≤2). Although there was sICH, there was one death associated with the procedure. Conclusion Mechanical thromboembolectomy with a retrievable stent followed by additional balloon angioplasty is a safe and effective first-line therapy for acute intracranial artery occlusions especially in case of unsuccessful recanalization after stent thrombectomy.
Genetic Algorithm for Restrictive Channel Routing Problem 9

This paper presents a genetic algorithm for to the restrictive channel routing problem. The major advance of this algorithm over other GA approaches to this problem is the use of horizontal and vertical constraints in the chromosome encoding which eliminates unfeasible solutions. This representation leads to lower complexity, because repairing procedures become unnecessary; in addition the search space is reduced greatly. Competitive experimental results proving the consistency of the approach were obtained.
Zinc ion implantation-deposition technique improves the osteoblast biocompatibility of titanium surfaces

The plasma immersion ion implantation and deposition (PIIID) technique was used to implant zinc (Zn) ions into smooth surfaces of pure titanium (Ti) disks for investigation of tooth implant surface modification. The aim of the present study was to evaluate the surface structure and chemical composition of a modified Ti surface following Zn ion implantation and deposition and to examine the effect of such modification on osteoblast biocompatibility. Using the PIIID technique, Zn ions were deposited onto the smooth surface of pure Ti disks. The physical structure and chemical composition of the modified surface layers were characterized by scanning electron microscopy (SEM) and X-ray photoelectron spectroscopy (XPS), respectively. In vitro culture assays using the MG-63 bone cell line were performed to determine the effects of Zn-modified Ti surfaces following PIIID on cellular function. Acridine orange staining was used to detect cell attachment to the surfaces and cell cycle analysis was performed using flow cytometry. SEM revealed a rough ‘honeycomb’ structure on the Zn-modified Ti surfaces following PIIID processing and XPS data indicated that Zn and oxygen concentrations in the modified Ti surfaces increased with PIIID processing time. SEM also revealed significantly greater MG-63 cell growth on Zn-modified Ti surfaces than on pure Ti surfaces (P<0.05). Flow cytometric analysis revealed increasing percentages of MG-63 cells in S phase with increasing Zn implantation and deposition, suggesting that MG-63 apoptosis was inhibited and MG-63 proliferation was promoted on Zn-PIIID-Ti surfaces. The present results suggest that modification with Zn-PIIID may be used to improve the osteoblast biocompatibility of Ti implant surfaces.
Red clover for treatment of hot flashes and menopausal symptoms: A systematic review and meta-analysis

This study evaluated the efficacy of red clover to relieve hot flashes and menopausal symptoms in peri/postmenopausal women. Electronic databases (MEDLINE, Scopus and the Cochrane Library) were searched. The mean frequency of hot flashes in red clover groups was lower compared with that in the control groups (close to statistical significance). Difference in means (MD) of hot flashes frequency was − 1.99 (− 4.12–0.139; p = 0.067; heterogeneity P > 0.01; I2 = 94.93%; Random effect model). Subjective (vaginal dryness) and objective (maturation value) symptoms of vaginal atrophy showed a significant improvement with 80-mg dose of red clover. Red clover showed less therapeutic effect on psychology status, sexual problems and sleeping disorders. Red clover consumption may decrease frequency of hot flashes, especially in women with severe hot flashes (≥ 5 per day). Red clover may reduce other menopausal symptoms. Further trials are needed to confirm the current systematic review findings.
An algorithm for discovering deep order preserving submatrix in gene expression data

Recently, order preserving submatrix (OPSM) model has been widely applied in many fields, such as biological gene expression data analysis, finance data mining and recommendation system. OPSM model is widely used in gene data expression analysis because of its biological significance and noise robustness. However, most of existing algorithms for OPSMs mining are based on greedy strategy or Apriori principle, which will miss some meaningful OPSMs, especially Deep OPSMs that the biologists are interested in. In this paper, an algorithm for accurate OPSMs searching based on sequential pattern mining was proposed, which could find all OPSMs, especially those Deep OPSMs. The idea of dynamic programming, data structure of suffix tree and the branch and bound rules were combined to improve efficiency of the algorithm. The proposed algorithm was verified by real gene data through experiments on biological significance and algorithm performance. Experimental results demonstrated that it is a high-efficiency algorithm and can find meaningful results.