Miracle-dz/UniFAR-FTUs huggingface dataset:
Prevalence of Olfactory and Other Developmental Anomalies in Patients with Central Hypogonadotropic Hypogonadism

Introduction: Hypogonadotropic hypogonadism (HH) is a heterogeneous disease caused by mutations in several genes. Based on the presence of hyposmia/anosmia it is distinguished into Kallmann syndrome (KS) and isolated HH. The prevalence of other developmental anomalies is not well established. Methods: We studied 36 patients with HH (31 males, 5 females, mean age 41.5), 9 with familial and 27 with sporadic HH (33 congenital, 3 adult-onset), by physical examination, smell test (BSIT Sensonics), audiometry, renal ultrasound, and magnetic resonance imaging of the olfactory structures. Results: Based on the smell test, patients were classified as normosmic (n = 21, 58.3%) and hypo/anosmic (n = 15, 41.6%). Hypoplasia/agenesis of olfactory bulbs was found in 40% of patients (10/25; 75% hypo/anosmic, 7.6% normosmic, p < 0.01, Fisher’s test). Remarkably, olfactory structures were normal in two anosmic patients, while one normosmic patient presented a unilateral hypoplastic bulb. Fourteen of 33 patients (42.4%) presented neurosensorial hearing loss of various degrees (28.5% hypo/anosmic, 52.6% normosmic, p = NS). Renal ultrasound revealed 27.7% of cases with renal anomalies (26.6% hypo/anosmic, 28.5% normosmic, p = NS). At least one midline defect was found in 50% of the patients (53.3% hypo/anosmic, 47.6% normosmic, p = NS), including abnormal palate, dental anomalies, pectus excavatum, bimanual synkinesis, iris coloboma, and absent nasal cartilage. Anamnestically 4/31 patients reported cryptorchidism (25% hypo/anosmic, 5.2% normosmic, p = NS). Conclusion: Hypo/anosmia is significantly related to anatomical anomalies of the olfactory bulbs/tracts but the prevalence of other developmental anomalies, especially midline defects and neurosensorial hearing loss, is high both in HH and KS and independent of the presence of anosmia/hyposmia. From the clinical standpoint KS and normosmic HH should be considered as the same complex, developmental disease.
Lost in Translation? Challenges and Opportunities for Raising Health and Safety Awareness among a Multinational Workforce in the United Arab Emirates

The United Arab Emirates (UAE) has experienced tremendous economic and industrial growth in the petroleum, airline, maritime and construction sectors, especially since the discovery of oil reserves. Mass recruitment of low skilled or unskilled laborers from less-developed countries has been utilized to satisfy the manpower demands of these fast paced industrial developments. Such workforce recruitment has created an unusual populace demographic, with the total UAE population estimated at 8.3 million, composed of 950,000 Emiratis, with the remainder being multinational expatriate workers, with varying educational qualifications, work experience, religious beliefs, cultural practices, and native languages. These unique characteristics pose a challenge for health and safety professionals tasked with ensuring the UAE workforce adheres to specific occupational health and safety procedures. The paper discusses two case studies that employ a novel multimedia approach to raising health and safety awareness among a multinational workforce.
A new HAD algorithm for optimal routing of hierarchically structured data networks

In this paper a new algorithm based on aggregation/disaggregation and decomposition/composition (HAD) scheme is proposed to solve the optimal routing problems (ORP) for hierarchically structured networks. Our algorithm has two major differences with the existing HAD algorithms for hierarchically clustered networks: 1. Our algorithm works with networks which are more general than networks with clustered structure; 2. Our algorithm parallelizes the computations for different commodities so that it speeds up with a parallel time complexity of O(mlog/sup 2/(n)), which is much less than O(Mlog/sup 2/(n)) needed for the existing HAD algorithms, for an n-node network with M commodities. Here, m is a positive number usually much smaller than M and is a function of the patterns of all the commodities. The implementation of the algorithm for a 200-node network is simulated using the OPNET simulation package.
Arteriosclerosis, Thrombosis, and Vascular Biology.

BACKGROUND: Reactive oxygen species (ROS) contribute to platelet hyperactivation during aging. Several oxidative pathways and antioxidant enzymes have been implicated; however, their mechanistic contributions during aging remain elusive. We hypothesized that mitochondria are an important source of platelet ROS and that mitochondrial SOD2 (superoxide dismutase) protects against mitochondrial ROS-driven platelet activation and thrombosis during aging. METHODS: We studied littermates of platelet-specific SOD2-knockout (SOD2 fl/fl Pf4Cre, pSOD2-KO) and control (SOD2 fl/fl ) mice at young (4–5 months) or old (18–20 months) ages. We examined agonist-induced platelet activation, platelet-dependent thrombin generation potential, and susceptibility to in vivo thrombosis. RESULTS: Platelet α IIb β 3 activation, aggregation, and adhesion were increased to similar extents in aged mice of both genotypes compared with young mice. In contrast, the age-dependent increases in mitochondrial and total cellular ROS, calcium elevation, and phosphatidylserine exposure were augmented in platelets from pSOD2-KO mice compared with control mice. Aged pSOD2-KO mice showed increased platelet-dependent thrombin generation compared with aged control mice. In vivo, aged pSOD2-KO mice exhibited enhanced susceptibility to carotid artery and pulmonary thrombosis compared to aged control mice. Adoptive transfer of platelets from aged pSOD2-KO but not aged control mice increased thrombotic susceptibility in aged host mice, suggesting a prothrombotic effect of platelet pSOD2 deficiency. Treatment with avasopasem manganese (GC4419), a SOD mimetic, decreased platelet mitochondrial pro-oxidants, cellular ROS levels, and inhibited procoagulant platelet formation and arterial thrombosis in aged mice. CONCLUSIONS: Platelet mitochondrial ROS contributes to age-related thrombosis and endogenous SOD2 protects from platelet-dependent thrombin generation and thrombosis during aging. GRAPHIC ABSTRACT: A graphic abstract is available for this article.
Tests of executive functions in first-degree relatives of schizophrenic patients: a meta-analysis

Background. Executive dysfunctions in relatives of schizophrenic patients may be trait markers of genetic liability and thus help us to elucidate the aetiology of schizophrenia. As a large amount of data has been published, a synthesis through a meta-analysis was needed to demonstrate the existence of executive impairments in relatives of schizophrenic patients and to assess their magnitude. Method. We conducted a meta-analysis of articles that compared performances of controls and relatives of schizophrenic patients on the four tests most frequently used to assess executive functions: the Wisconsin Card Sorting Test (WCST), the Trail Making Test (TMT), the Stroop Test and the Verbal Fluency (VF) Test. When needed and possible, published data were supplemented with information from the authors. After assessing the homogeneity of the data, effect sizes were estimated and publication bias was tested by use of funnel plots. Results. Relatives of schizophrenic patients performed less well than controls on all executive tests analysed. Effect estimates were in the small to moderate range (from 0·26 to 0·49) for Stroop, WCST and TMT, but were greater for the fluency tests (0·65 for phonological and 0·87 for semantic VF). Conclusion. Relatives of schizophrenic patients appear to have wide, although not severe, executive dysfunctions. As the sensitivity of the different tests for impairments in relatives is not the same, the choice of test and method used should be carefully assessed.
How Introverts versus Extroverts Approach Small-Group Argumentative Discussions

This research explored disparities between how students with different degrees of extroversion and introversion engaged in small-group discussions requiring the construction and critique of arguments. 2 studies were conducted. In the first study, 8 sixth-grade students from 2 classes discussed urban planning dilemmas in 2 small groups outside the classroom. Discussions were videotaped. Based on student responses to a short personality questionnaire, the 8 target students were selected from the extremes of the classroom distribution (4 extroverts and 4 introverts). The more extroverted students made significantly more contradictions and counterexamples during small-group discussions with other extroverts, indicating a greater tendency to use conflictual discourse. In contrast, the more introverted students worked with one another collaboratively to develop creative solutions. A replication study was conducted using 16 preservice teachers enrolled in an introductory educational psychology course; this study yielded similar results. Possible explanations of these findings are discussed.
Deep LSTM for Large Vocabulary Continuous Speech Recognition

Recurrent neural networks (RNNs), especially long short-term memory (LSTM) RNNs, are effective network for sequential task like speech recognition. Deeper LSTM models perform well on large vocabulary continuous speech recognition, because of their impressive learning ability. However, it is more difficult to train a deeper network. We introduce a training framework with layer-wise training and exponential moving average methods for deeper LSTM models. It is a competitive framework that LSTM models of more than 7 layers are successfully trained on Shenma voice search data in Mandarin and they outperform the deep LSTM models trained by conventional approach. Moreover, in order for online streaming speech recognition applications, the shallow model with low real time factor is distilled from the very deep model. The recognition accuracy have little loss in the distillation process. Therefore, the model trained with the proposed training framework reduces relative 14\% character error rate, compared to original model which has the similar real-time capability. Furthermore, the novel transfer learning strategy with segmental Minimum Bayes-Risk is also introduced in the framework. The strategy makes it possible that training with only a small part of dataset could outperform full dataset training from the beginning.
PubRec: Recommending Publications Based on Publicly Available Meta-Data

In recent years we can observe a steady growth of scien- tic publications in increasingly diverse scientic elds. Current digital libraries and retrieval systems make searching these publications easy, but determining which of these are relevant for a specic person re- mains a challenge. This becomes even harder if we constrain ourselves to publicly available meta-data, as complete information (in particular the fulltext) is rarely accessible due to licensing issues. In this paper we propose to model researcher prole as a multivariate linear regression problem leveraging meta-data like abstracts and titles in order to achieve eective publication recommendation. We also evaluate the proposed ap- proach and show its eectiveness compared with competing approaches.
Effect of Cognitive Behavior Group Therapy on Parenting Stress in Mothers of Children With Autism

Background: Due to the various problems of children with autism, their families and especially their mothers become exposed to stress. Objectives: This study aimed to evaluate the effect of cognitive behavior group therapy on parenting stress of mothers of children with autism. Materials and Methods: The sample of this research consisted of sixteen mothers of children with autism. The measurement tools were the Abidin Parenting Stress questionnaire and a demographic questionnaire. The samples participated in seven sessions of cognitive behavior group therapy. The data were analyzed using the repeated measures test. Results: The findings indicated significant differences between scores of pretest and posttest considering parenting stress (P = 0.03) and subscales of parenting distress (P = 0.01), yet there weren’t significant differences in the other subscales (P > 0.05). Conclusions: Cognitive behavior group therapy could be an important part of interventions used to decrease parenting stress of mothers of children with autism.
Effect of syntactic similarity on cortical activation during second language processing: A comparison of English and Japanese among native Korean trilinguals

In this study of native Korean trilinguals we examined the effect of syntactic similarity between first (L1) and second (L2) languages on cortical activation during the processing of Japanese and English, which are, respectively, very similar to and different from Korean. Subjects had equivalent proficiency in Japanese and English. They performed auditory sentence comprehension tasks in Korean, Japanese, and English during functional MRI (fMRI). The bilateral superior temporal cortex was activated during the comprehension of three languages. The pars triangularis of the left inferior frontal gyrus (IFG) was additionally activated for L2 processing. Furthermore, the right cerebellum, the pars opercularis of the left IFG, and the posteriomedial part of the superior frontal gyrus were activated during the English tasks only. We observed significantly greater activation in the pars opercularis of the left IFG, the right cerebellum, and the right superior temporal cortex during the English than Japanese task; activation in these regions did not differ significantly between Korean and Japanese. Differential activation of the pars opercularis of the left IFG and the right cerebellum likely reflects syntactic distance and differential activation in the right superior temporal cortex may reflect the prosodic distance between English from Korean and Japanese. Furthermore, in the pars oparcularis of the left IFG and the right cerebellum, significant negative correlation between the activation and duration of exposure was observed for English, but not for Japanese. Our research supports the notion that linguistic similarity between L1 and L2 affects the cortical processing of second language. Hum Brain Mapp, 2007. © 2006 Wiley‐Liss, Inc.
Prognostic cytogenetic markers in childhood acute lymphoblastic leukemia: Cases from Mansoura Egypt

Abstract The objective of the work was to evaluate children with acute lymphoblastic leukemia (ALL) showing resistance to immediate induction chemotherapy in relation to conventional and advanced cytogenetic analysis. The study was conducted on 63 ALL children (40 males and 23 females) with age range 4.5 months–16 years (mean = 7.76 years). They included 37 cases who attained a true remission and 26 complicated by failure of remission, early relapse or death. They were subjected to history, clinical examination and investigations including CBC, BM examination, karyotyping, FISH for translocations and flowcytometry for immunophenotyping and minimal residual disease diagnosis. Cases aged <5 years; male sex with organomegaly had better remission although statistically insignificant. Initially low HB <8 gm/dl, high WBCs and platelet counts >50.000/mm3 also showed better but non-significant remission rates. Most of our cases were L2 with better remission compared to other immunophenotypes. About 40 informative karyotypes were subdivided into 15 hypodiploid, 10 pseudodiploid, 8 normal diploid and 7 hyperdiploid cases; the best remission rates were noticed among the most frequent ploidy patterns. Chromosomes 9, 11 and 22 were the most frequently involved by structural aberrations followed by chromosomes 5, 12 and 17. Resistance was noted with aberrations not encountered among remission group; deletions involving chromosomes 2p, 3q, 10p and 12q; translocations involving chromosome 5; trisomies of chromosomes 16 and 21; monosomies of 5 and X and inversions of 5 and 11. Our conclusions were that cytogenetic and molecular characterizations of childhood ALL could add prognostic criteria for proper therapy allocation.
Suicide in the 18 Years After Deliberate Self-harm

Background Clinical and demographic information on patients seen as a result of deliberate self-harm (DSH) was collected in an attempt to identify factors in the index episode of DSH predictive of subsequent suicide. Method Specific data were prospectively collected on all DSH patients who lived in Blacktown Municipality, Sydney, Australia, and seen from October 1975 to September 1976. Follow-up at 18 years was by evaluation of coroners' records and identification of ‘probable suicide’. Results Two hundred and twenty-three patients harmed themselves on one or more occasions. Follow-up at 18 years showed that 15 of the 223 (6.7%) had completed suicide. The proportion at five and eight years was 4.0% and at 10 years was 4.5%. Identified predictors of suicide were: narcotic overdose; more than one episode of DSH in the year of the study; planned episode; and mental illness. Teenage narcotic-abusing males were at greatest risk, and in females a planned episode was the most powerful predictor. Conclusions Suicides continued to occur over 18 years. One of the striking differences between this and other studies is the finding of teenage male DSH, associated with narcotic abuse, as a strong predictor of subsequent suicide. These findings are particularly relevant to the issue of young male suicide, which increased from the 1970s onwards in Australia and elsewhere.
Rate of HIV-1 RNA rebound upon stopping antiretroviral therapy.

OBJECTIVE To determine the rate of plasma HIV-1 RNA rebound in patients stopping highly active antiretroviral therapy (HAART) after achieving undetectable viral load. DESIGN Sequential plasma HIV RNA levels were measured in six patients during the 21 days following withdrawal from HAART. METHODS Plasma samples were obtained from six patients who chose to withdraw from HAART because of lipodystrophy, narcotic overdose, insomnia and/or high blood pressure. Longitudinal plasma viral load was determined in triplicate upon stopping therapy. RESULTS All patients had plasma viral loads below 50 HIV RNA copies/ml at the time of stopping therapy and had had levels below 500 copies/ml for a median of 390 days (range 39-542 days). Plasma HIV rebound upon stopping therapy was rapid (median increase 0.2 log/day; range 0.15-0.42 log/day) and initially appeared to follow first-order kinetics. Plasma HIV RNA levels returned to greater than 500 copies/ml within 6 to 15 days (median 10 days) and approached or exceeded pre-therapy levels in all patients within 21 days of stopping therapy. Extrapolating backwards to the time at which individuals stopped therapy suggested that patients had tens of thousands of total body plasma HIV RNA copies despite having 'undetectable' plasma HIV RNA. CONCLUSIONS HIV RNA in plasma rebounds within days of stopping antiretroviral therapy. A considerable burden of total body plasma HIV RNA likely remains even during effective HAART therapy.
Building a Community of Young Leaders

This study assesses whether more frequent participation in Jewish activist learning events is associated with higher levels of engagement in social justice-related activities and conceptions of Jewish identity. The study design was cross-sectional and comparative. An online survey was completed by 165 participants in an activist learning program. Results indicated higher levels of social justice engagement, local engagement, ethical consumption and, Jewish social justice. However, there was no significant increase in Jewish identity. Results differed depending on the frequency of participation. Findings suggest that activist learning programs may be an effective method for teaching and promoting social justice engagement.
The Effect of Pair Work on a Word-Building Task.

This paper reports on a study that was carried out to investigate the effect of pair work on a word-building task in two EFL classes. Forty Iranian adult students participated in this study. The participants in the experimental group completed the word-building task in pairs following the Think-Pair-Share technique, whereas the participants in the control group did the same task individually. Results of the data analysis showed that the participants in the experimental group achieved significantly higher scores on the given task than the participants in the control group. This indicates that the students’ joint efforts while collaborating with each other are likely to result in co-construction of morphological knowledge.
Robust formation tracking control of mobile robots via one-to-one time-varying communication

We solve the formation tracking control problem for mobile robots via linear control, under the assumption that each agent communicates only with one ‘leader’ robot and with one follower, hence forming a spanning-tree topology. We assume that the communication may be interrupted on intervals of time. As in the classical tracking control problem for non-holonomic systems, the swarm is driven by a fictitious robot which moves about freely and which is a leader to one robot only. Our control approach is decentralised and the control laws are linear with time-varying gains; in particular, this accounts for the case when position measurements may be lost over intervals of time. For both velocity-controlled and force-controlled systems, we establish uniform global exponential stability, hence consensus formation tracking, for the error system under a condition of persistency of excitation on the reference angular velocity of the virtual leader and on the control gains.
Link Between DNA Damage and Centriole Disengagement/Reduplication in Untransformed Human Cells

The radiation and radiomimetic drugs used to treat human tumors damage DNA in both cancer cells and normal proliferating cells. Centrosome amplification after DNA damage is well established for transformed cell types but is sparsely reported and not fully understood in untransformed cells. We characterize centriole behavior after DNA damage in synchronized untransformed human cells. One hour treatment of S phase cells with the radiomimetic drug, Doxorubicin, prolongs G2 by at least 72 h, though 14% of the cells eventually go through mitosis in that time. By 72 h after DNA damage we observe a 52% incidence of centriole disengagement plus a 10% incidence of extra centrioles. We find that either APC/C or Plk activities can disengage centrioles after DNA damage, though they normally work in concert. All disengaged centrioles are associated with γ‐tubulin and maturation markers and thus, should in principle be capable of reduplicating and organizing spindle poles. The low incidence of reduplication of disengaged centrioles during G2 is due to the p53‐dependent expression of p21 and the consequent loss of Cdk2 activity. We find that 26% of the cells going through mitosis after DNA damage contain disengaged or extra centrioles. This could produce genomic instability through transient or persistent spindle multipolarity. Thus, for cancer patients the use of DNA damaging therapies raises the chances of genomic instability and evolution of transformed characteristics in proliferating normal cell populations. J. Cell. Physiol. 229: 1427–1436, 2014. © 2014 Wiley Periodicals, Inc.