Miracle-dz/UniFAR-FTUs huggingface dataset:
Modeling the Stochastic Drift of a MEMS-Based Gyroscope in Gyro/Odometer/GPS Integrated Navigation

To have a continuous navigation solution that does not suffer from interruption, GPS is integrated with relative positioning techniques such as odometry and inertial navigation. Targeting a low-cost navigation solution for land vehicles, this paper uses a reduced multisensor system consisting of one microelectromechanical-system (MEMS)-based single-axis gyroscope used together with the vehicle's odometer, and the whole system is integrated with GPS. This system provides a 2-D navigation solution, which is adequate for land vehicles. The traditional technique for this multisensor integration problem is Kalman filtering (KF). Due to the inherent errors of MEMS inertial sensors and their stochastic nature, which is difficult to model, the KF with its linearized models has limited capabilities in providing accurate positioning. Particle filtering (PF) has recently been suggested as a nonlinear filtering technique to accommodate arbitrary inertial sensor characteristics, motion dynamics, and noise distributions. An enhanced version of PF is utilized in this paper and is called the Mixture PF. Since PF can accommodate nonlinear models, this paper uses total-state nonlinear system and measurement models. In addition, sophisticated models are used to model the stochastic drift of the MEMS-based gyroscope. A nonlinear system identification technique based on parallel cascade identification (PCI) is used to model this stochastic gyroscope drift. In this paper, the performance of the PCI model is compared with that of higher order autoregressive (AR) stochastic models. Such higher order models are difficult to use with KF since the size of the dynamic matrix and the error-covariance matrix becomes very large and complicates the KF operation. The performance of the proposed 2-D navigation solution using Mixture PF with both PCI and higher order AR models is examined by road-test trajectories in a land vehicle. The two proposed combinations are compared with four other 2-D solutions: a Mixture PF with the Gauss-Markov (GM) model for the gyro drift, a Mixture PF with only white Gaussian noise (WGN) for stochastic gyro errors, and two different KF solutions with GM model for the gyro drift. The experimental results show that the two proposed solutions outperform all the compared counterparts.
Understanding of Factors that Enable Health Promoters in Implementing Health-Promoting Schools: A Systematic Review and Narrative Synthesis of Qualitative Evidence

Health-promoting schools have been regarded as an important initiative in promoting child and adolescent health in school settings using the whole-school approach. Quantitative research has proved its effectiveness in various school-based programmes. However, few qualitative studies have been conducted to investigate the strategies used by health promoters to implement such initiatives. In this study, the researchers conducted a systematic review and narrative synthesis of the qualitative literature to identify important enablers assisting the implementation of health-promoting schools from the perspectives of health promoters. Five enablers have been identified from the review: (a) Following a framework/guideline to implement health-promoting schools; (b) Obtaining committed support and contributions from the school staff, school board management, government authorities, health agencies and other stakeholders; (c) Adopting a multidisciplinary, collaborative approach to implementing HPS; (d) Establishing professional networks and relationships; and (e) Continuing training and education in school health promotion. This highlights the importance of developing school health policies that meet local health needs, and socio-cultural characteristics that can foster mutual understanding between the health and education sectors so as to foster health promotion in children and adolescents.
Colored Maximum Variance Unfolding

Maximum variance unfolding (MVU) is an effective heuristic for dimensionality reduction. It produces a low-dimensional representation of the data by maximizing the variance of their embeddings while preserving the local distances of the original data. We show that MVU also optimizes a statistical dependence measure which aims to retain the identity of individual observations under the distance-preserving constraints. This general view allows us to design "colored" variants of MVU, which produce low-dimensional representations for a given task, e.g. subject to class labels or other side information.
Voltage-dependent block of the cystic fibrosis transmembrane conductance regulator Cl- channel by two closely related arylaminobenzoates

The gene defective in cystic fibrosis encodes a Cl- channel, the cystic fibrosis transmembrane conductance regulator (CFTR). CFTR is blocked by diphenylamine-2-carboxylate (DPC) when applied extracellularly at millimolar concentrations. We studied the block of CFTR expressed in Xenopus oocytes by DPC or by a closely related molecule, flufenamic acid (FFA). Block of whole-cell CFTR currents by bath-applied DPC or by FFA, both at 200 microM, requires several minutes to reach full effect. Blockade is voltage dependent, suggesting open-channel block: currents at positive potentials are not affected but currents at negative potentials are reduced. The binding site for both drugs senses approximately 40% of the electric field across the membrane, measured from the inside. In single-channel recordings from excised patches without blockers, the conductance was 8.0 +/- 0.4 pS in symmetric 150 mM Cl-. A subconductance state, measuring approximately 60% of the main conductance, was often observed. Bursts to the full open state lasting up to tens of seconds were uninterrupted at depolarizing membrane voltages. At hyperpolarizing voltages, bursts were interrupted by brief closures. Either DPC or FFA (50 microM) applied to the cytoplasmic or extracellular face of the channel led to an increase in flicker at Vm = -100 mV and not at Vm = +100 mV, in agreement with whole-cell experiments. DPC induced a higher frequency of flickers from the cytoplasmic side than the extracellular side. FFA produced longer closures than DPC; the FFA closed time was roughly equal (approximately 1.2 ms) at -100 mV with application from either side. In cell-attached patch recordings with DPC or FFA applied to the bath, there was flickery block at Vm = -100 mV, confirming that the drugs permeate through the membrane to reach the binding site. The data are consistent with the presence of a single binding site for both drugs, reached from either end of the channel. Open-channel block by DPC or FFA may offer tools for use with site-directed mutagenesis to describe the permeation pathway.
Stability of positive continuous-time linear systems with delays

The asymptotic stability of positive continuous-time linear systems with delays is addressed. It is shown that: 1) the asymptotic stability of the positive systems with delays is independent of their delays, 2) the checking of the asymptotic stability of the positive systems with delays can be reduced to checking of the asymptotic stability of positive systems without delays. Simple stability conditions for the positive systems with delays are give and illustrated by numerical examples.
Generation of arbitrary superpositions of the Dicke states of excitons in optically driven quantum dots

We present a scheme to generate arbitrary superpositions of Dicke states of excitons in optically driven quantum dots. The proposal is based on a sequence of laser pulses to control transitions between the nearest-neighbor Dicke states appropriately. It is shown that only N laser pulses are needed to generate arbitrary superpositions of Dicke states of N quantum dots.
The Operating Point of the Cortex: Neurons as Large Deviation Detectors

Spiking neurons translate analog intracellular variables into a sequence of action potentials. A simplified model of this transformation is one in which an underlying “generator potential,” representing a measure of overall neuronal drive, is passed through a static nonlinearity to produce an instantaneous firing rate. An important question is how adaptive mechanisms adjust the mean and SD of the generator potential to define an “operating point” that controls spike generation. In early sensory pathways adaptation has been shown to rescale the generator potential to maximize the amount of transmitted information. In contrast, we demonstrate that the operating point in the cortex is tuned so that cells respond only when the generator potential executes a large excursion above its mean value. The distance from the mean of the generator potential to spike threshold is, on average, 1 SD of the ongoing activity. Signals above threshold are amplified linearly and do not reach saturation. The operating point is adjusted dynamically so that it remains relatively invariant despite changes in stimulus contrast. We conclude that the operating regimen of the cortex is suitable for the detection of signals in background noise and for enhancing the selectivity of spike responses relative to those of the generator potential (the so-called “iceberg effect”), but not to maximize the transmission of total information.
Degenerative Neurological and Neuromuscular Disease Cell adhesion molecules in Alzheimer ’ s disease

Correspondence: Henrietta M Nielsen Molecular Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, The Wallenberg Laboratory 2nd Floor, Skåne University Hospital Malmö, 205 02 Malmö, Sweden Tel +46 40 335733 Fax +46 40 337041 Email henrietta.nielsen@med.lu. se Abstract: Cell adhesion molecules (CAMs) mediate interactions between cells and their surroundings that are vital to processes controlling for cell survival, activation, migration, and plasticity. However, increasing evidence suggests that CAMs also mediate mechanisms involved in several neurological diseases. This article reviews the current knowledge on the role of CAMs in amyloid-β (Aβ) metabolism, cell plasticity, neuroinflammation, and vascular changes, all of which are considered central to the pathogenesis and progression of Alzheimer’s disease (AD). This paper also outlines the possible roles of CAMs in current and novel AD treatment strategies.
A Cross-linked Profilin-Actin Heterodimer Interferes with Elongation at the Fast-growing End of F-actin*

Profilin and β/γ-actin from calf thymus were covalently linked using the zero-length cross-linker 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide in combination withN-hydroxysuccinimide, yielding a single product with an apparent molecular mass of 60 kDa. Sequence analysis and x-ray crystallographic investigations showed that the cross-linked residues were glutamic acid 82 of profilin and lysine 113 of actin. The cross-linked complex was shown to bind with high affinity to deoxyribonuclease I and poly(l-proline). It also bound and exchanged ATP with kinetics close to that of unmodified profilin-actin and inhibited the intrinsic ATPase activity of actin. This inhibition occurred even in conditions where actin normally forms filaments. By these criteria the cross-linked profilin-actin complex retains the characteristics of unmodified profilin-actin. However, the cross-linked complex did not form filaments nor copolymerized with unmodified actin, but did interfere with elongation of actin filaments in a concentration-dependent manner. These results support a polymerization mechanism where the profilin-actin heterodimer binds to the (+)-end of actin filaments, followed by dissociation of profilin, and ATP hydrolysis and Pi release from the actin subunit as it assumes its stable conformation in the helical filament.
TrimerDimer: an oligonucleotide-based saturation mutagenesis approach that removes redundant and stop codons

9-fluorenylmethoxycarbonyl (Fmoc) and 4,4′-dimethoxytrityl (DMTr) are orthogonal hydroxyl protecting groups that have been used in conjunction to assemble oligonucleotide libraries whose variants contain wild-type and mutant codons randomly interspersed throughout a focused DNA region. Fmoc is labile to organic bases and stable to weak acids, whereas DMTr behaves oppositely. Based on these chemical characteristics, we have now devised TrimerDimer, a novel codon-based saturation mutagenesis approach that removes redundant and stop codons during the assembly of degenerate oligonucleotides. In this approach, five DMTr-protected trinucleotide phosphoramidites (dTGG, dATG, dTTT, dTAT and dTGC) and five Fmoc-protected dinucleotide phosphoramidites (dAA, dTT, dAT, dGC and dCG) react simultaneously with a starting oligonucleotide growing on a solid support. The Fmoc group is then removed and the incorporated dimers react with a mixture of three DMTr-protected monomer phosphoramidites (dC, dA and dG) to produce 15 trinucleotides: dCAA, dAAA, dGAA, dCTT, dATT, dGTT, dCAT, dAAT, dGAT, dCGC, dAGC, dGGC, dCCG, dACG and dGCG. After one mutagenic cycle, 20 codons are generated encoding the 20 natural amino acids. TrimerDimer was tested by randomizing the four contiguous codons that encode amino acids L64–G67 of an engineered, nonfluorescent GFP protein. Sequencing of 89 nonfluorescent mutant clones and isolation of two fluorescent mutants confirmed the principle.
Emotional Labour of the Polish Social Workers: The Study in Sociology of Emotions

The article presents the results of a study conducted among a group of 55 highly experienced Polish social workers on the management of their emotions in contacts with clients. The research was inspired mainly by Arlie Hochschild’s concept of emotional labour. Using a qualitative approach allowed us to incorporate a wider range of the spontaneity and reflexivity expressed by the subjects of the study. The paper helps illustrate that, similarly to other helping professions, social workers deploy significant emotional labour and use a range of emotional strategies to affect their clients’ actions or behaviour. The effectiveness of such labour depends on experience, individual characteristics and the formal and informal support they have access to. We conclude that with experience such workers not only control their emotions better, but first and foremost become more effective in using their emotions in such a way as to encourage or discourage certain actions and behaviours among their clients. The findings indicate that more attention should be placed on the role of emotions and emotional labour used by social workers in their daily practice. Incorporation of elements of the sociology of emotions might be particularly useful in this regard.
Average Stand Age from Forest Inventory Plots Does Not Describe Historical Fire Regimes in Ponderosa Pine and Mixed-Conifer Forests of Western North America

Quantifying historical fire regimes provides important information for managing contemporary forests. Historical fire frequency and severity can be estimated using several methods; each method has strengths and weaknesses and presents challenges for interpretation and verification. Recent efforts to quantify the timing of historical high-severity fire events in forests of western North America have assumed that the “stand age” variable from the US Forest Service Forest Inventory and Analysis (FIA) program reflects the timing of historical high-severity (i.e. stand-replacing) fire in ponderosa pine and mixed-conifer forests. To test this assumption, we re-analyze the dataset used in a previous analysis, and compare information from fire history records with information from co-located FIA plots. We demonstrate that 1) the FIA stand age variable does not reflect the large range of individual tree ages in the FIA plots: older trees comprised more than 10% of pre-stand age basal area in 58% of plots analyzed and more than 30% of pre-stand age basal area in 32% of plots, and 2) recruitment events are not necessarily related to high-severity fire occurrence. Because the FIA stand age variable is estimated from a sample of tree ages within the tree size class containing a plurality of canopy trees in the plot, it does not necessarily include the oldest trees, especially in uneven-aged stands. Thus, the FIA stand age variable does not indicate whether the trees in the predominant size class established in response to severe fire, or established during the absence of fire. FIA stand age was not designed to measure the time since a stand-replacing disturbance. Quantification of historical “mixed-severity” fire regimes must be explicit about the spatial scale of high-severity fire effects, which is not possible using FIA stand age data.
Risk factors for parvovirus B19 infection in pregnancy.

CONTEXT Parvovirus B19 infection during pregnancy has been associated with fetal death. However, the incidence of and risk factors for infection in pregnant women have not been well studied. OBJECTIVES To estimate a pregnant woman's risk of infection with parvovirus B19 in epidemic and endemic situations and to study risk factors for infection. DESIGN Population-based cohort study conducted between November 1992 and June 1994. SETTING Three regions in Denmark. PARTICIPANTS A total of 30946 pregnant women from a consecutive and population-based screening. MAIN OUTCOME MEASURES Specific IgG antibodies in serum samples obtained in the first trimester of pregnancy and from the newborn infant to assess past infection and seroconversion. Information on family structure, educational background, socioeconomic status, and pregnancy outcome was obtained from national registers. RESULTS Based on 30 946 serum samples, 65.0% of pregnant women had evidence of past infection. Annual seroconversion rates among susceptible women during endemic and epidemic periods were 1.5% (95% confidence interval [CI], 0.2%-1.9%) and 13.0% (95% CI, 8.7%-23.1 %), respectively. Baseline seropositivity was significantly correlated with increasing number of siblings, having a sibling of the same age, number of own children, and occupational exposure to children. Risk of acute infection increased with the number of children in the household as follows: 0 children odds ratio (OR), 1 (reference); 1 child OR, 3.17 (95% CI, 2.24-4.49); 2 children OR, 5.47 (95% CI, 3.55-8.45); 3 or more children OR, 7.54 (95% CI, 3.80-14.94). Having children aged 6 to 7 years resulted in the highest rate of seroconversion among mothers (6.8%; OR, 4.07; 95% CI, 1.89-8.73). Compared with other pregnant women, nursery school teachers had a 3-fold increased risk of acute infection (OR, 3.09; 95% CI, 1.62-5.89). Population-attributable risk of seroconversion was 55.4% for number of own children and 6.0% for occupational exposure. CONCLUSIONS The risk of infection is high for susceptible pregnant women during epidemics and associated with the level of contact with children. Nursery school teachers have the highest occupational risk, but most infections seem to be the result of exposure to the woman's own children.
Default risk and corporate governance in financial vs. non-financial firms

This study explores the relation between credit risks of financial and non-financial firms and their corporate governance structures from the perspective of creditors. US based CDS spreads are used to measure firms' risk taking behavior. Governance attributes have differential effects across firm types: Board independence and financial transparency have a greater impact on the default risk of financial firms than on industrial firms. Ownership structure and takeover vulnerability are more important for industrial firms than for financial firms. For industrial firms, CEO ownership has a nonlinear relation with credit risk levels with an inflection point of around 40%, At ownership levels below (above) the inflection point, increased CEO ownership is associated with increased (decreased) credit risk. These results are consistent with an entrenchment effect: at a low level of ownership, the interests of CEOs are more aligned to shareholders than bondholders. For financial firms, CEO ownership is associated with lower default probability only when CEOs hold a large fraction of the firms' shares.
Resveratrol Inhibits CD4+ T Cell Activation by Enhancing the Expression and Activity of Sirt1

Resveratrol, a natural polyphenol compound, has broad effects on critical events, including inflammation, oxidation, cancer and aging. However, the function and molecular mechanisms of resveratrol on T cell activation are controversial. In the present study, we found that resveratrol significantly inhibits the activation and cytokine production of T cells in vitro and in vivo. Sirt1 expression was up-regulated in resveratrol-treated T cells. Once Sirt1 was down-regulated in the T cells, the resveratrol-induced inhibition of T cell activation noticeably diminished. The acetylation of c-Jun decreased and its translocation was impeded in the resveratrol-treated T cells. The incidence and severity of collagen-induced arthritis in the resveratrol-treated mice were considerably reduced.
Reliable Fast Frequency Sweep for Microwave Devices via the Reduced-Basis Method

In this paper, a reduced-basis-approximation-based model-order reduction for fast and reliable frequency sweep in the time-harmonic Maxwell's equations is detailed. Contrary to what one may expect by observing the frequency response of different microwave circuits, the electromagnetic field within these devices does not drastically vary as frequency changes in a band of interest. Thus, instead of using computationally inefficient, large dimension, numerical approximations such as finite- or boundary-element methods for each frequency in the band, the point in here is to approximate the dynamics of the electromagnetic field itself as frequency changes. A much lower dimension, reduced-basis approximation sorts this problem out. Not only rapid frequency evaluation of the reduced-order model is carried out within this approach, but also special emphasis is placed on a fast determination of the error measure for each frequency in the band of interest. This certifies the accurate response of the reduced-order model. The same scheme allows us, in an offline stage, to adaptively select the basis functions in the reduced-basis approximation and automatically select the model-order reduction process whenever a preestablished accuracy is required throughout the band of interest. Finally, real-life applications will illustrate the capabilities of this approach.