Miracle-dz/UniFAR-FTUs huggingface dataset:
Volunteered Geographic Information in Natural Hazard Analysis: A Systematic Literature Review of Current Approaches with a Focus on Preparedness and Mitigation

With the rise of new technologies, citizens can contribute to scientific research via Web 2.0 applications for collecting and distributing geospatial data. Integrating local knowledge, personal experience and up-to-date geoinformation indicates a promising approach for the theoretical framework and the methods of natural hazard analysis. Our systematic literature review aims at identifying current research and directions for future research in terms of Volunteered Geographic Information (VGI) within natural hazard analysis. Focusing on both the preparedness and mitigation phase results in eleven articles from two literature databases. A qualitative analysis for in-depth information extraction reveals auspicious approaches regarding community engagement and data fusion, but also important research gaps. Mainly based in Europe and North America, the analysed studies deal primarily with floods and forest fires, applying geodata collected by trained citizens who are improving their knowledge and making their own interpretations. Yet, there is still a lack of common scientific terms and concepts. Future research can use these findings for the adaptation of scientific models of natural hazard analysis in order to enable the fusion of data from technical sensors and VGI. The development of such general methods shall contribute to establishing the user integration into various contexts, such as natural hazard analysis.
Irritable bowel syndrome according to varying diagnostic criteria: are the new Rome II criteria unnecessarily restrictive for research and practice?

OBJECTIVES:It has been suggested that the variation in the prevalence of irritable bowel syndrome (IBS) may be due to the application of different diagnostic criteria. New criteria for IBS have been proposed (Rome II). It is unknown whether persons meeting different criteria for IBS have similar psychological and symptom features. The aim of this study was to measure the prevalence of IBS according to Manning and Rome definitions of IBS and to evaluate the clinical and psychological differences between diagnostic categories.METHODS:A total of 4500 randomly selected subjects, with equal numbers of male and female subjects aged ≥18 yr and representative of the Australian population, took part in this study. Subjects were mailed a questionnaire (response rate, 72%). Characteristics measured were gastrointestinal symptoms over the past 12 months, neuroticism and extroversion (Eysenck Personality Questionnaire), anxiety and depression (Delusions-Symptoms-States Inventory), mental and physical functioning (SF-12), and somatic distress (Sphere). RESULTS:The prevalence for IBS according to Manning, Rome I, and Rome II was 4.4% (95% confidence interval [CI] = 3.5–5.1%), 6.9% (CI 6.0–7.8%), and 13.6% (CI 12.3–14.8%), respectively. Only 12 persons with Rome I did not also meet Rome II criteria; 196 persons with Manning criteria did not meet Rome II cut-offs. Having IBS regardless of which criteria were used was significantly associated with psychological morbidity, but psychological factors were not important in discriminating between diagnostic categories. However, pain and bowel habit severity independently discriminated between diagnostic groups.CONCLUSIONS:IBS is a relatively common disorder in the community. The new Rome II criteria may be unnecessarily restrictive in practice.
Arctic Ocean surface warming trends over the past 100 years

Ocean temperature profiles and satellite data have been analyzed for summertime sea surface temperature (SST) and upper ocean heat content variations over the past century, with a focus on the Arctic Ocean peripheral seas. We find that many areas cooled up to ∼0.5°C per decade during 1930–1965 as the Arctic Oscillation (AO) index generally fell, while these areas warmed during 1965–1995 as the AO index generally rose. Warming is particularly pronounced since 1995, and especially since 2000. Summer 2007 SST anomalies are up to 5°C. The increase in upper ocean summertime warming since 1965 is sufficient to reduce the following winter's ice growth by as much as 0.75 m. Alternatively, this heat may return to the atmosphere before any ice forms, representing a fall freeze‐up delay of two weeks to two months. This returned heat might be carried by winds over terrestrial tundra ecosystems, contributing to the local heat budget.
Intensive Therapy in Newly Diagnosed Type 2 Diabetes

Background This study aimed to assess the efficacy of early intensive diabetes therapy with either insulin plus metformin (INS) or triple oral therapy (TOT) with metformin, glyburide, and pioglitazone on glycemic control and A-cell function. Methods Fifty-eight treatment-naive newly diagnosed patients with type 2 diabetes underwent a 3-month lead-in treatment period with insulin and metformin, then were randomized to INS or TOT for 6 years. β-Cell function was measured using mixed-meal challenge test. β-Cell function remained stable throughout the 6-year study in both groups, as measured by the C-peptide area under the curve (AUC; P = 0.13), the AUC C-peptide/AUC glucose (P = 0.9), and by the disposition index (P = 0.8). Excellent glycemic control was maintained in both groups (end-of-study hemoglobinA1c, 7.3% [SD, 1.7%] INS vs 6.4% [1.4%] TOT; P = 0.4). There were 8 treatment failures (confirmed hemoglobinA1c, 98%) in INS and 6 in TOT (P = 0.93). The predictors of treatment failure included higher fasting glucose (P = 0.008), fasting C-peptide (P = 0.008), systolic blood pressure (P = 0.004), and lower insulin sensitivity (P = 0.04) at randomization. Conclusions Early intensive treatment at the time of type 2 diabetes diagnosis—initial short-term insulin treatment followed by either insulin-based or intensive oral hypoglycemic–based therapy—stabilizes β-cell function for at least 6 years. Treatment failure was independent of intervention and was associated with worse disease pathology at baseline.
Microcephaly is not mandatory for the diagnosis of mosaic variegated aneuploidy syndrome

The phenotype of mosaic variegated aneuploidy (MVA) syndrome is characterized by severe microcephaly, growth deficiency, mental retardation, and mild physical anomalies. The MVA syndrome is associated with mosaicism for several different aneuploidies involving many different chromosomes with or without premature centromere division (PCD). To date 28 cases of MVA syndrome have been reported. We report the first case of MVA syndrome without microcephaly. The clinical features in our patient included craniofacial dysmorphic features, growth retardation, and developmental delay. Cytogenetics analyses and FISH studies showed multiple aneuploidy with trisomy 18, 19, and 8, respectively in blood lymphocyte and fibroblastes without PCD. This case is compared with the other of MVA syndrome previously reported in literature. From this case report, we suggest that microcephaly is not mandatory for the diagnosis of MVA syndrome. © 2005 Wiley‐Liss, Inc.
A literature review of the impact of a monitoring coping style on psychological adjustment in people with real or potentially life threatening illness and An investigation of psychological adjustment and coping style in patients undergoing bone marrow/stem cell transplantation

Volume I contains a literature review and an empirical paper. The literature review, which is presented first, reviews recent findings for a relationship between informational coping style and psychological adjustment in patients confronted with potential or real life threatening illness. Empirical data is systematically reviewed within the theoretical framework of Miller's (1995) Monitoring Process Model. Suggestions are made for future research on order to develop effective interventions for those individuals who are most vulnerable to psychological, social, and emotional complications secondary to their illness. The empirical paper examines psychological distress in patients undergoing stem cell transplantation in a prospective longitudinal design. Specific aims are to examine the degree of psychological distress over the course of transplantation, which pre-treatment demographic, medical and psychosocial factors predict psychological distress and adjustment after transplantation, and whether informational coping style was associated with distress levels before and after transplantation. The findings of this study illustrate the need for pre-treatment assessment and intervention, focusing on treatment related anxiety management, depression, and dysfunctional illness attributions which may help reduce post-treatment distress. [Volume II contains a series of clinical practice reports and is not available online. ]
Cost and benefit estimation of experts' mediation in an enterprise search

The success of an enterprise information retrieval system is determined by interactions among three key entities: the search engine employed; the service provider who delivers, modifies, and maintains the engine; and the users of the service within the organization. Evaluations of an enterprise search have predominately focused on the effectiveness and efficiency of the engine, with very little analysis of user involvement in the process, and none on the role of service providers. We propose and evaluate a model of costs and benefits to a service provider when investing in enhancements to the ranking of documents returned by their search engine. We demonstrate the model through a case study to analyze the potential impact of using domain experts to provide enhanced mediated search results. By demonstrating how to quantify the cost and benefit of an improved information retrieval system to the service provider, our case study shows that using the relevance assessments of domain experts to rerank original search results can significantly improve the accuracy of ranked lists. Moreover, the service provider gains substantial return on investment and a higher search success rate by investing in the relevance assessments of domain experts. Our cost and benefit analysis results are contrasted with standard modes of effectiveness analysis, including quantitative (using measures such as precision) and qualitative (through user preference surveys) approaches. Modeling costs and benefits explicitly can provide useful insights that the other approaches do not convey.
Variations in Gene Expression and Response to Neoadjuvant Chemotherapy in Breast Carcinoma

In this study, we performed a screening of 266 gene expressions in breast carcinomas and carried out correlations with histological response to either FEC-100 (fluorouracil-epirubicin-cyclophosphamide; n = 16) or Tax-Epi (docetaxel-epirubicin; n = 12) treatment. Gene expression in biopsies obtained before and after one course of chemotherapy was analyzed. Expression of specific genes was significantly changed after one course of chemotherapy, particularly for Tax-Epi treatment. Comparison with histological response for both treatments revealed that only good responders exhibited changes in gene-expression profile. These results agree that expression of different genes changes in response to anthracycline-based neoadjuvant chemotherapy and show, for the first time, that response to docetaxel-based treatment implied also changes in gene-expression profile.
Antiretroviral Therapy Outcomes among Adolescents and Youth in Rural Zimbabwe

Around 2 million adolescents and 3 million youth are estimated to be living with HIV worldwide. Antiretroviral outcomes for this group appear to be worse compared to adults. We report antiretroviral therapy outcomes from a rural setting in Zimbabwe among patients aged 10–30 years who were initiated on ART between 2005 and 2008. The cohort was stratified into four age groups: 10–15 (young adolescents) 15.1–19 years (adolescents), 19.1–24 years (young adults) and 24.1–29.9 years (older adults). Survival analysis was used to estimate rates of deaths and loss to follow-up stratified by age group. Endpoints were time from ART initiation to death or loss to follow-up. Follow-up of patients on continuous therapy was censored at date of transfer, or study end (31 December 2008). Sex-adjusted Cox proportional hazards models were used to estimate hazard ratios for different age groups. 898 patients were included in the analysis; median duration on ART was 468 days. The risk of death were highest in adults compared to young adolescents (aHR 2.25, 95%CI 1.17–4.35). Young adults and adolescents had a 2–3 times higher risk of loss to follow-up compared to young adolescents. When estimating the risk of attrition combining loss to follow-up and death, young adults had the highest risk (aHR 2.70, 95%CI 1.62–4.52). This study highlights the need for adapted adherence support and service delivery models for both adolescents and young adults.
Foot–terrain interaction mechanics for legged robots: Modeling and experimental validation

Contact mechanics plays an important role in the design, performance analysis, simulation, and control of legged robots. The Hunt–Crossley model and the Coulomb friction model are often used as black-box models with limited consideration of the properties of the terrain and the feet. This paper analyzes the foot–terrain interaction based on the knowledge of terramechanics and reveals the relationship between the parameters of the conventional models and the terramechanics models. The proposed models are derived in three categories: deformable foot on hard terrain, hard foot on deformable terrain, and deformable foot on deformable terrain. A novel model of tangential forces as the function of displacement is proposed on the basis of an in-depth understanding of the terrain properties. Methods for identifying the model parameters are also developed. Extensive foot–soil interaction experiments have been carried out, and the experimental results validate the high fidelity of the derived models.
Treatment of joint prosthesis infection in accordance with current recommendations improves outcome.

BACKGROUND Recently recommended treatment modalities for prosthetic joint infection (PJI) were evaluated. METHODS A retrospective cohort analysis of 68 patients with PJI of hip or knee who were treated from 1995 through 2004 was conducted at the University Hospital Bern (Bern, Switzerland). RESULTS A 2-stage exchange was the most frequent (75.0%) surgical strategy, followed by retention and debridement (17.6%), 1-stage exchange (5.9%), and resection arthroplasty or suppressive antimicrobial treatment (1.5%). The chosen strategy was in 88% agreement with the recommendations. Adherence was only 17% for retention and debridement and was 0% for 1-stage exchange. Most PJIs (84%) were treated with an adequate or partially adequate antimicrobial regimen. Recurrence-free survival was observed in 51.5% of PJI episodes after 24 months of follow-up. The risk of treatment failure was significantly higher for PJI treated with a surgical strategy other than that recommended (hazard ratio, 2.34; 95% confidence interval, 1.10-4.70; P = .01) and for PJIs treated with antibiotics not corresponding to recommendations (hazard ratio, 3.45; confidence interval, 1.50-7.60; P = .002). Other risk factors associated with lack of healing were a high infection score at the time of diagnosis (hazard ratio, 1.29; 95% confidence interval, 1.10-1.40; P < .001) and presence of a sinus tract (hazard ratio, 2.35; 95% confidence interval, 1.10-5.0; P = .02). CONCLUSIONS Our study demonstrates the value of current treatment recommendations. Inappropriate choice of conservative surgical strategies (such as debridement and retention) and inadequate antibiotic treatment are associated with failure.
Elevated Abundance, Size, and MicroRNA Content of Plasma Extracellular Vesicles in Viremic HIV-1+ Patients: Correlations With Known Markers of Disease Progression

Background:Because of factors only partly understood, the generalized elevated immune activation and inflammation characterizing HIV-1–infected patients are corrected incompletely with antiretroviral therapy (ART). Extracellular vesicles (EVs) including exosomes and microvesicles released by several cell types may contribute to immune activation and dysfunction. EV size, abundance, and content appear to differ according to infection phase, disease progression, and ART. Methods:We examined whether the size of EVs and the abundance of exosomes in plasma are associated with cell and tissue activation as well as with viral production. Acetylcholinesterase-bearing (AChE+) exosomes in plasma were quantified using an AChE assay. EV size was analyzed using dynamic light scattering. Proteins and microRNAs present in EVs were detected by Western blot and real-time polymerase chain reaction, respectively. Results:Exosomes were found more abundant in the plasma of ART-naive patients. EV size was larger in ART-naive than in ART-suppressed patients, elite controllers, or healthy control subjects. Both exosome abundance and EV sizes were inversely correlated with CD4/CD8 T-cell ratio and neutrophil, platelet, and CD4 T-cell counts and positively correlated with CD8 T-cell counts. A negative correlation was found between CD4 T-cell nadir and exosome abundance, but not EV size. Levels of miR-155 and miR-223 but not miR-92 were strongly correlated negatively with EV abundance and size in ART-naive patients. Conclusions:Monitoring of circulating EVs and EV-borne microRNA is possible and may provide new insight into HIV-1 pathogenesis, disease progression, and the associated inflammatory state, as well as the efficacy of ART and the treatments intended to reduce immune activation.
Central vein stenosis in an Asian hemodialysis population

Objective and background: Central vein stenosis occurs commonly after instrumentation of the major thoracic veins. We aimed to investigate factors that contributed to this condition in an Asian hemodialysis population, and the results of intervention. Patients and methods: Hemodialysis patients diagnosed with central vein stenosis between January 2003 and December 2008, were identified from the records of the National University Hospital, Singapore. Eligible controls had a minimum of 2 years of hemodialysis via an arteriovenous fistula and/or central venous catheter, without clinical or radiological evidence of central vein stenosis. Results: Central vein stenosis was diagnosed in 108 patients. The most common presenting features were arm swelling (32%) and failed hemodialysis catheter insertion (28%). The median frequency of permanent hemodialysis catheter insertion in those who subsequently developed venous stenosis (1.44 per patient per year) was 4 times that of controls (0.36 per patient per year; p < 0.001). Ischemic heart disease (p = 0.03) and in certain patients, arteriovenous fistula surgery were associated with the development of central vein stenosis; whereas line sepsis, diabetes, and hypertension were not. Central vein angioplasty was attempted in 53 patients; the primary patency was 52% at 1 year. Conclusion: Central vein stenosis is associated with a higher frequency of hemodialysis catheter insertion and access surgery. Efforts to decrease permanent hemodialysis catheter use should reduce the incidence of central vein stenosis.
Chronic Infection of the Prostate by Chlamydia muridarum Is Accompanied by Local Inflammation and Pelvic Pain Development

Chlamydia trachomatis urogenital infections are the leading cause of sexually transmitted bacterial infections. Although the prevalence of chlamydial infection is similar in men and women, current research is mainly focused on women, neglecting the study of male genital tract infections. We, therefore, investigated Chlamydia infection in the rodent male genital tract.
Can Patel's τ accurately estimate directionality of connections in brain networks from fMRI?

Investigating directional interactions between brain regions plays a critical role in fully understanding brain function. Consequently, multiple methods have been developed for noninvasively inferring directional connectivity in human brain networks using functional MRI (fMRI). Recent simulations by Smith et al. showed that Patel's τ, a method based on higher‐order statistics, was the best approach for inferring directional interactions from fMRI. Because simulations make restrictive assumptions about reality, we set out to verify this finding using experimental fMRI data obtained from a three‐region network in a rat model with electrophysiological validation.
Intention does not always Matter: The Contingent Role of Habit in IT Usage Behaviour

The ability to predict IT usage behavior has been an important area of inquiry in IS research for many years. Yet, to date, the predominant approach has been on the conscious cognitive aspect of this behavior. Consequently, the primary focus has been on the formation of intentions and its impact on the subsequent behavior of IT usage almost to the exclusion of other factors. The purpose of this study is to highlight an alternative viewpoint that suggests the equally important role of the automatic response known as habit. Applying theories of human behavior, we developed a model that shows the impact of both intentions and habit on IT usage. More importantly, we demonstrate that the influence of intention on usage will vary depending on the level of one’s habit. This finding implies that there can be situations where intention will, in fact, have no impact on behavior and that further research is needed to understand these conditions and the factors that lead to such situations.
Embedded Binarized Neural Networks

We study embedded Binarized Neural Networks (eBNNs) with the aim of allowing current binarized neural networks (BNNs) in the literature to perform feedforward inference efficiently on small embedded devices. We focus on minimizing the required memory footprint, given that these devices often have memory as small as tens of kilobytes (KB). Beyond minimizing the memory required to store weights, as in a BNN, we show that it is essential to minimize the memory used for temporaries which hold intermediate results between layers in feedforward inference. To accomplish this, eBNN reorders the computation of inference while preserving the original BNN structure, and uses just a single floating-point temporary for the entire neural network. All intermediate results from a layer are stored as binary values, as opposed to floating-points used in current BNN implementations, leading to a 32x reduction in required temporary space. We provide empirical evidence that our proposed eBNN approach allows efficient inference (10s of ms) on devices with severely limited memory (10s of KB). For example, eBNN achieves 95\% accuracy on the MNIST dataset running on an Intel Curie with only 15 KB of usable memory with an inference runtime of under 50 ms per sample. To ease the development of applications in embedded contexts, we make our source code available that allows users to train and discover eBNN models for a learning task at hand, which fit within the memory constraint of the target device.
INTEGRAL high energy observations of 2S 0114+65

We report the first INTEGRAL timing and spectral analysis of the high mass X-ray binary source 2S 0114+65 at high energies (5–100 keV). The pulse period was found at 2.668 h with a high pulsed fraction, ~80% in both the 20–40 keV and 40–80 keV energy bands. The spin-up trend over ~8 years was measured to be $\dot P = -8.9$ $\times$ 10 -7 s s -1 . The hard X-ray spectrum obtained with JEM-X/ISGRI is well described by a high energy exponential cut-off power law model where the estimated luminosity is 1.8 $\times$ 10 36 erg s -1 in the 5–100 keV energy band, for a source distance of 7.2 kpc. We tentatively identify a cyclotron resonance scattering feature at ~22 keV with one harmonic, implying a magnetic field of ~2.5 $\times$ 10 12 G.