Miracle-dz/UniFAR-FTUs huggingface dataset:
El tabú y el disfemismo en jóvenes colegiales costarricenses.

The primary objective of this article is to register the dysphemisms that the students of the eleventh year of college expressed through a survey, which used the methodology of lexical availability. As the main result there are a lot of obtained dysphemisms terms related to sex, even in areas of interest that are unrelated to the topic.
Triggering of chloride ion efflux from human neutrophils as a novel function of leukocyte beta 2 integrins: relationship with spreading and activation of the respiratory burst.

PMN residing on immobilized fibronectin have been shown to respond to TNF with an intense and long lasting Cl- efflux that leads to a marked decrease of the unusually high basal Cl- content of these phagocytes. The finding that this Cl- efflux depends, at least in part, on beta2 integrin engagement stimulated the present investigation, which addresses the question as to whether beta2 integrins per se, in the absence of PMN agonists, are able to generate signals triggering Cl- efflux. We induced beta2 integrin cross-linking by plating PMN onto surface-bound mAbs directed against either the common beta-chain (CD18) or the individual alpha-chains (CD11a, CD11b, CD11c) of LFA-1, CR3, and gp150/95. Anti-CD18 mAbs triggered a marked release of Cl- ions, which was accompanied by spreading and activation of the respiratory burst. Cross-linking of gp150/95 and LFA-1 generated the most powerful signals for the activation of Cl- efflux. The results of three independent experimental approaches, i.e., kinetic studies, use of Cl- transport inhibitors, and modulation of Cl- efflux with different amounts of anti-beta2 integrin mAbs, indicated that Cl- efflux regulates both spreading and respiratory burst triggered by beta2 integrin cross-linking. Cl- efflux appears to be independent on either alterations of [Ca2+]i or changes in the plasma membrane potential and shows sensitivity to a raise in pHi. This study uncovers a new signaling ability of beta2 integrins and contributes to highlight the role of Cl- efflux in the outside-in signal transduction pathway regulating adherence-dependent PMN responses.
Reduced Resting-State Functional Connectivity of the Somatosensory Cortex Predicts Psychopathological Symptoms in Women with Bulimia Nervosa

Background: Alterations in the resting-state functional connectivity (rs-FC) of several brain networks have been demonstrated in eating disorders. However, very few studies are currently available on brain network dysfunctions in bulimia nervosa (BN). The somatosensory network is central in processing body-related stimuli and it may be altered in BN. The present study therefore aimed to investigate rs-FC in the somatosensory network in bulimic women. Methods: Sixteen medication-free women with BN (age = 23 ± 5 years) and 18 matched controls (age = 23 ± 3 years) underwent a functional magnetic resonance resting-state scan and assessment of eating disorder symptoms. Within-network and seed-based functional connectivity analyses were conducted to assess rs-FC within the somatosensory network and to other areas of the brain. Results: Bulimia nervosa patients showed a decreased rs-FC both within the somatosensory network (t = 9.0, df = 1, P = 0.005) and with posterior cingulate cortex and two visual areas (the right middle occipital gyrus and the right cuneus) (P = 0.05 corrected for multiple comparison). The rs-FC of the left paracentral lobule with the right middle occipital gyrus correlated with psychopathology measures like bulimia (r = −0.4; P = 0.02) and interoceptive awareness (r = −0.4; P = 0.01). Analyses were conducted using age, BMI (body mass index), and depressive symptoms as covariates. Conclusion: Our findings show a specific alteration of the rs-FC of the somatosensory cortex in BN patients, which correlates with eating disorder symptoms. The region in the right middle occipital gyrus is implicated in body processing and is known as extrastriate body area (EBA). The connectivity between the somatosensory cortex and the EBA might be related to dysfunctions in body image processing. The results should be considered preliminary due to the small sample size.
Coping, Social Support, and Depressive Symptoms of Older Adults with Type II Diabetes Mellitus

Abstract This study examined the effects of coping and social support on the adaptation to Type II diabetes mellitus of elderly Chinese patients. The age of the subjects (N=200) ranged from 60 to 92 years (mean = 70.96, SD=5.84). The duration of illness since its first detection ranged from half a year to 36 years (mean = 9.14, SD=6.95). Data were collected in face-to-face interviews with a structured questionnaire. The results indicated that the patients did not perceive diabetes as severely threatening to their daily activities. Compared with a normal sample of elderly people, these diabetic elderly patients did not exhibit a higher level of depressive symptoms as measured by GDS-15.Concealment of feelings was most significantly associated with depressive symptoms. General social support appeared to be more beneficial than diabetic-specific support. Support from friends played a more significant role in the adaptation to diabetes mellitus than support from family network.
Secondary-structure prediction revisited: Theoretical β-sheet propensity and coil propensity represent structures of amyloids and aid in elucidating phenomena involved in interspecies transmission of prions

Prions are unique infectious agents, consisting solely of abnormally-folded prion protein (PrPSc). However, they possess virus-like features, including strain diversity, the ability to adapt to new hosts and to be altered evolutionarily. Because prions lack genetic material (DNA and RNA), these biological phenomena have been attributed to the structural properties of PrPSc. Therefore, many structural models of the structure of PrPSc have been proposed based on the limited structural information available, regardless of the incompatibility with high-resolution structural analysis. Recently hypothesized models consist solely of β-sheets and intervening loops/kinks; i.e. parallel in-register β-sheet and β-solenoid models. Owing to the relative simplicity of these structural models of PrPSc, we hypothesized that numerical conversion of the primary structures with a relevant algorithm would enable quantitative comparison between PrPs of distinct primary structures. We therefore used the theoretical values of β-sheet (Pβ) and random-coil (Pc) propensity calculated by secondary structure prediction with a neural network, to analyze interspecies transmission of prions. By reviewing experiments in the literature, we ascertained the biological relevance of Pβ and Pc and found that these classical parameters surprisingly carry substantial information of amyloid structures. We also demonstrated how these parameters could aid in interpreting and explaining phenomena in interspecies transmissions. Our approach can lead to the development of a versatile tool for investigating not only prions but also other amyloids.
Which competitive advantages can firms really obtain from ISO14001 certification

Ten years after the introduction of ISO14001, in this paper we present empirical evidence about the competitive advantages that managers associate to this environmental practice, from a sample of industrial firms located in Spain. The results indicate that the potential competitive advantages are: improvement of the internal efficiency, differentiation advantages, attention to the stakeholders’ requirements, enhancement of the competitive position in the sector and financial savings. Nevertheless managers’ expectations of improving internal efficiency might be the real reason that encourages firms to make the voluntary decision of investing in ISO14001 certification
Robust Spot-Packaged Microsphere-Taper Coupling Structure for In-Line Optical Sensors

We propose and realize a spot-packaged structure for the microsphere-taper coupling system by only encapsulating and solidifying the coupling region with low refractive index polymer as the package material. After spot-package, ultrahigh quality factor ( >; 107) is obtained with the microsphere diameters around 300 μm. The robustness of the spot-packaged structure is also tested, demonstrating the remarkable anti-tensile strength ability with the bearable loaded force larger than 0.05 N for a packaged structure with the spot-package area larger than 30 μm2. In addition, the spot-packaged structure is integrated with standard fiber, promising in in-line optical practical evanescent field sensing applications, especially in harsh detecting environments demanding high overload resistance.
FACTORS AFFECTING PERSONAL PROTECTIVE EQUIPMENT USE BEHAVIOR IN WELDING WORKSHOP WORKERS

Welding workshops are informal sector businesses with a high risk of hazards that require occupational safety and health (OSH) efforts, such as the use of personal protective equipment (PPE). Some welding accidents are caused by PPE factors. The purpose of this study was to analyze the factors that influence the behavior of wearing PPE in welding workshop workers. This study used an observational analytic type with a cross-sectional design. The population of this study was 41 welding workshop workers, all of whom were used as samples (total sampling). The variables measured were age, length of service, education, knowledge about PPE, attitude towards PPE, availability of PPE, and behavior of wearing PPE. Statistical analysis used Multiple Binary Logistic Regression using SPSS 27 software, at α = 5%. The results of the analysis showed that the factors that influence the behavior of wearing PPE are knowledge about PPE (OR = 2.12; p = 0.040), attitude towards PPE (OR = 2.37; p = 0.034), and availability of PPE (OR = 4.27; p = 0.038). The regression coefficient shows a positive value, which means that an increase in knowledge about PPE (β = 0.754), attitude towards PPE (β = 0.865), and availability of PPE (β = 1.453) will increase the behavior of wearing PPE.
Gender Differences in How Leaders Determine Succession Potential: The Role of Interpersonal Fit With Followers

This paper examined the existence of gender differences in the degree to which leaders’ perceptions of successor potential is influenced by interpersonal fit. In Study 1 (N = 97 leaders, N = 280 followers), multi-source field data revealed that for male leaders, ratings of followers’ potential as successors were positively related to interpersonal fit, measured by the degree to which followers’ saw their leadership as being close and interpersonal (i.e., being coaching, transformational, and leading by example). For female leaders, these relationships were absent, suggesting that they are less influenced by interpersonal fit. In Study 2 (N = 311 leaders), a scenario study provided causal evidence that male leaders rated potential successors more positively when they perceived greater interpersonal fit with followers, whereas female leaders’ successor ratings were not informed by perceptions of fit. We discuss the theoretical and practical implications for gendered leadership successor perceptions in organizations.
Changing epidemiology of hepatitis A and hepatitis E in urban and rural India (1982–98)

The epidemiology of hepatitis A virus (HAV) and hepatitis E virus (HEV) was assessed among age‐stratified urban high socioeconomic, lower middle socioeconomic status and rural populations from western India in 1998. When compared with previous surveys, a clear shift from high to intermediate endemicity of HAV was evident only for higher socioeconomic population (1982–98), raising the possibility of outbreaks of hepatitis A in this category. A decrease in anti‐HAV positivity was noted in rural children aged 6–10 years. Lower circulation of HEV was noted among < 25‐year‐old urban higher socioeconomic and rural individuals. For both viruses, the lower middle socioeconomic populations were comparable in 1982 and 1998. Socioeconomic status and family size (odds ratio=23 and 1.6, respectively) were independently associated with anti‐HAV positivity. Age, lower middle socioeconomic status and well water were significant independent variables for HEV infection (odds ratio=5.7, 2.4 and 1.9, respectively). Hence, vaccination policy for hepatitis A needs to be reviewed.
The Transcriptome of the Salivary Glands of Amblyomma aureolatum Reveals the Antimicrobial Peptide Microplusin as an Important Factor for the Tick Protection Against Rickettsia rickettsii Infection

The salivary glands (SG) of ixodid ticks play a pivotal role in blood feeding, producing both the cement and the saliva. The cement is an adhesive substance that helps the attachment of the tick to the host skin, while the saliva contains a rich mixture of antihemostatic, anti-inflammatory, and immunomodulatory substances that allow ticks to properly acquire the blood meal. The tick saliva is also a vehicle used by several pathogens to be transmitted to the vertebrate host, including various bacterial species from the genus Rickettsia. Rickettsia rickettsii is a tick-borne obligate intracellular bacterium that causes the severe Rocky Mountain spotted fever. In Brazil, the dog yellow tick Amblyomma aureolatum is a vector of R. rickettsii. In the current study, the effects of an experimental infection with R. rickettsii on the global gene expression profile of A. aureolatum SG was determined by next-generation RNA sequencing. A total of 260 coding sequences (CDSs) were modulated by infection, among which 161 were upregulated and 99 were downregulated. Regarding CDSs in the immunity category, we highlight one sequence encoding one microplusin-like antimicrobial peptide (AMP) (Ambaur-69859). AMPs are important effectors of the arthropod immune system, which lack the adaptive response of the immune system of vertebrates. The expression of microplusin was confirmed to be significantly upregulated in the SG as well as in the midgut (MG) of infected A. aureolatum by a quantitative polymerase chain reaction preceded by reverse transcription. The knockdown of the microplusin expression by RNA interference caused a significant increase in the prevalence of infected ticks in relation to the control. In addition, a higher rickettsial load of one order of magnitude was recorded in both the MG and SG of ticks that received microplusin-specific dsRNA. No effect of microplusin knockdown was observed on the R. rickettsii transmission to rabbits. Moreover, no significant differences in tick engorgement and oviposition were recorded in ticks that received dsMicroplusin, demonstrating that microplusin knockdown has no effect on tick fitness. Further studies must be performed to determine the mechanism of action of this AMP against R. rickettsii.
Analysis of LRRK2 functional domains in nondominant Parkinson disease

A comprehensive sequence analysis of 29 exons that code for the functional domains of LRRK2 in 160 nondominant Parkinson disease (PD) patients was performed. Novel variant screening in a further 470 sporadic PD patients and 630 controls revealed two novel variants (R1067Q and IVS33 + 6 T>A), which are likely to be pathogenic in five patients. One patient presented initially with a typical essential tremor phenotype, expanding the phenotypic spectrum of LRRK2 mutations.
Dietary Patterns and Prostate Cancer Risk: Report from the Population Based ULSAM Cohort Study of Swedish Men

Dietary pattern analyses have increased the possibilities to detect associations between diet and disease. However, studies on dietary pattern and prostate cancer are scarce. Food intake data in the Uppsala Longitudinal Study of Adult Men cohort was determined by 7-day food records. Adherence to a modified Mediterranean Diet Score (mMDS) and a low carbohydrate–high protein (LCHP) score were grouped as low, medium, or high in the whole study population (n = 1,044) and in those identified as adequate reporters of energy intake (n = 566), respectively. Prostate cancer risk was analyzed with Cox proportional hazard regression (median follow-up 13 years) and competing risk of death was considered. There were no associations between dietary patterns and prostate cancer (n = 133) in the whole study population. Among adequate reporters the mMDS was not associated with prostate cancer (n = 72). The LCHP score was inversely related to prostate cancer in adequate reporters, adjusted hazard ratios; 0.55 (0.32–0.96) for medium and 0.47 (0.21–1.04) for high compared to low adherent participants (P-for-trend 0.04). Risk relations were not attributable to competing risk of death. In this study, a LCHP diet was associated with lower prostate cancer incidence. Relations emerged in adequate reporters, underscoring the importance of high-quality dietary data.
Strengthened monotonicity of relative entropy via pinched Petz recovery map

The quantum relative entropy between two states satisfies a monotonicity property, meaning that applying the same quantum channel to both states can never increase their relative entropy. It is known that this inequality is only tight when there is a “recovery map” that exactly reverses the effects of the quantum channel on both states. In this paper we strengthen this inequality by showing that the difference of relative entropies is bounded below by the measured relative entropy between the first state and a recovered state from its processed version. The recovery map is a convex combination of rotated Petz recovery maps and perfectly reverses the quantum channel on the second state. As a special case we reproduce recent lower bounds on the conditional mutual information such as the one proved in [Fawzi and Renner, Commun. Math. Phys., 2015]. Our proof only relies on elementary properties of pinching maps and the operator logarithm.
CONTAMINATION IN THE KEPLER FIELD. IDENTIFICATION OF 685 KOIs AS FALSE POSITIVES VIA EPHEMERIS MATCHING BASED ON Q1–Q12 DATA

The Kepler mission has to date found almost 6000 planetary transit-like signals, utilizing three years of data for over 170,000 stars at extremely high photometric precision. Due to its design, contamination from eclipsing binaries, variable stars, and other transiting planets results in a significant number of these signals being false positives (FPs). This directly affects the determination of the occurrence rate of Earth-like planets in our Galaxy, as well as other planet population statistics. In order to detect as many of these FPs as possible, we perform ephemeris matching among all transiting planet, eclipsing binary, and variable star sources. We find that 685 Kepler Objects of Interest (KOIs)—12% of all those analyzed—are FPs as a result of contamination, due to 409 unique parent sources. Of these, 118 have not previously been identified by other methods. We estimate that ∼35% of KOIs are FPs due to contamination, when performing a first-order correction for observational bias. Comparing single-planet candidate KOIs to multi-planet candidate KOIs, we find an observed FP fraction due to contamination of 16% and 2.4% respectively, bolstering the existing evidence that multi-planet KOIs are significantly less likely to be FPs. We also analyze the parameter distributions of the ephemeris matches and derive a simple model for the most common type of contamination in the Kepler field. We find that the ephemeris matching technique is able to identify low signal-to-noise FPs that are difficult to identify with other vetting techniques. We expect FP KOIs to become more frequent when analyzing more quarters of Kepler data, and note that many of them will not be able to be identified based on Kepler data alone.
Growth in the Shadow of Expropriation

In this paper, we propose a tractable variant of the open economy neoclassical growth model that emphasizes political economy and contracting frictions. The political economy frictions involve disagreement and political turnover, while the contracting friction is a lack of commitment regarding foreign debt and expropriation. We show that the political economy frictions induce growth dynamics in a limited-commitment environment that would otherwise move immediately to the steady state. In particular, greater political disagreement corresponds to a high tax rate on investment, which declines slowly over time, generating slow convergence to the steady state. While in the standard neoclassical growth model capital's share in production plays an important role in determining the speed of convergence, this parameter is replaced by political disagreement in our open economy reformulation. Moreover, while political frictions shorten the horizon of the government, the government may still pursue a path of tax rates in which the first best investment is achieved in the long run, although the transition may be slow. The model rationalizes why openness has different implications for growth depending on the political environment, why institutions such as respect for property rights evolve over time, why governments in open countries that grow rapidly tend to accumulate net foreign assets rather than liabilities, and why foreign aid may not affect growth.
Efficient Branch and Bound on FPGAs Using Work Stealing and Instance-Specific Designs

Branch and bound (B8B) algorithms structure the search space as a tree and eliminate infeasible solutions early by pruning subtrees that cannot lead to a valid or optimal solution. Custom hardware designs significantly accelerate the execution of these algorithms. In this article, we demonstrate a high-performance B8B implementation on FPGAs. First, we identify general elements of B8B algorithms and describe their implementation as a finite state machine. Then, we introduce workers that autonomously cooperate using work stealing to allow parallel execution and full utilization of the target FPGA. Finally, we explore advantages of instance-specific designs that target a specific problem instance to improve performance. We evaluate our concepts by applying them to a branch and bound problem, the reconstruction of corrupted AES keys obtained from cold-boot attacks. The evaluation shows that our work stealing approach is scalable with the available resources and provides speedups proportional to the number of workers. Instance-specific designs allow us to achieve an overall speedup of 47 × compared to the fastest implementation of AES key reconstruction so far. Finally, we demonstrate how instance-specific designs can be generated just-in-time such that the provided speedups outweigh the additional time required for design synthesis.
Adaptive Response, Evidence of Cross-Resistance and Its Potential Clinical Use

Organisms and their cells are constantly exposed to environmental fluctuations. Among them are stressors, which can induce macromolecular damage that exceeds a set threshold, independent of the underlying cause. Stress responses are mechanisms used by organisms to adapt to and overcome stress stimuli. Different stressors or different intensities of stress trigger different cellular responses, namely induce cell repair mechanisms, induce cell responses that result in temporary adaptation to some stressors, induce autophagy or trigger cell death. Studies have reported life-prolonging effects of a wide variety of so-called stressors, such as oxidants, heat shock, some phytochemicals, ischemia, exercise and dietary energy restriction, hypergravity, etc. These stress responses, which result in enhanced defense and repair and even cross-resistance against multiple stressors, may have clinical use and will be discussed, while the emphasis will be on the effects/cross-effects of oxidants.