Miracle-dz/UniFAR-FTUs huggingface dataset:
Randomized controlled trial on lateral augmentation using two collagen membranes: morphometric results on mineralized tissue compound.

BACKGROUND Guided bone regeneration is considered an effective tool for gaining mineralized tissue either at exposed implant surface or in deficient alveolar ridge areas before implant placement. MATERIAL AND METHODS Customized casts obtained following impression taking at surgery and re-entry allowed for morphometric assessment of alveolar ridge alterations 6 months after one-stage augmentation of bone dehiscences. In a randomized pilot study using biphasic calcium phosphate tests (n=17) received treatment with ribose cross-linked collagen membranes (RCLM), whereas controls (n=20) received non-cross-linked membranes. The primary endpoint was to quantify the effect of membrane type on dimensional changes in bone margins at crestal level of endosseous implants. RESULTS Soft tissue dehiscencies occurred at 70.5% and 55% frequency for tests and controls, respectively. Gain in clinically hard newly mineralized tissue at the crestal level was significantly higher in test group in lateral (1.8 versus 0.7 mm; p=.046) and in vertical dimensions (1.1 versus 0.2 mm; p=.035) compared with controls. Second measurement obtained at the border of reflected flap revealed no significant difference between groups (3.0 versus 2.1 mm; p=0.57) for lateral dimension. CONCLUSIONS Both collagen devices were effective in bone augmentation. RCLMs supported mineralization process and remodelling even in sites showing compromised healing as indicated by morphometric outcome.
Abagovomab for ovarian cancer

Introduction: Ovarian cancer (OC) is the fifth most common cancer in women. Unfortunately, more than 70% of cases are detected at an advanced stage with a risk of recurrence, after front line therapy, of over 75%. The need for new therapeutic strategies is extremely high. Areas covered: The development status and the possible role of specific immunotherapy of abagovomab are discussed in the context of the possible therapeutic options for maintenance therapy in advanced OC. An overview of abagovomab, generation and mechanism of action, Phase I/II results and the status of the Phase II/III ongoing trial is given. Expert opinion: Abagovomab stimulates the humoral immune response and the cell-mediated immune response in the studies conducted to date. In the proof of concept (POC) study abagovomab prolonged overall survival in those OC recurrent patients who showed an immune response. Abagovomab has an excellent safety and tolerability profile. These characteristics make abagovomab an optimal candidate for a maintenance treatment for OC patients after frontline therapy. The final results of the Phase II/III pivotal study evaluating abagovomab in this setting will be available in the first half of 2011.
Simulation Of Maritime Transit Traffic In The Istanbul Strait – II: Incorporating The Traffic Regime, Arrival Processes, Meteorological Conditions

This study aims to significantly augment and extend an earlier simulation model on the maritime transit traffic in the Istanbul Strait. The new model reflects the new traffic regime, which is in effect since the middle of 2005. This model also incorporates the probabilistic behavior of vessel arrivals and other characteristics, current & visibility conditions, based on extensive past data. Model inputs are parameters associated with the Traffic Control Center decisions, as well as randomized vessel arrival rates / profiles and current/visibility conditions. The model outputs, such as, numbers and waiting times of vessel types in queues, vessel densities and pilot/tugboat utilizations, are designed to facilitate a better understanding of the effects of inputs (individually or in an aggregate manner) through comparisons of a series of scenarios. An additional accomplishment will be the comparison of the new traffic regime with the earlier one, based on the collation of model outputs with those of the previous model (which reflects the earlier regime).
Comparison between Various Software Development Methodologies

From the beginning of software development, it always tried to formulate some process or process sequences or steps to develop or making software. Development of software should be in systematic manner. Today there are variety of software projects some require only good GUI, some require security, some software are made for mission critical tasks, for all these different types of projects require different type of model for development of software. Few well know software development models are waterfall, v-shaped, agile, and object-oriented. All these have their own advantages and disadvantages. This paper try to solve the problem of choosing right methodology for particular software by comparing all software development methodologies. It also figure out the advantages and disadvantages of different methodologies in useful manner not to criticize, so that a particular model will be chosen by an organization or company. This paper divided into two parts first is dedicated to advantage and disadvantages and second part id for comparison between all most popular software development life cycle models. This paper also used for choosing best model for particular project for developing particular software. This paper broadly categorize all software development models into four categories flow based model, iteration based model, object oriented model, structured based model.
Independent Value of Cardiac Troponin T and Left Ventricular Global Longitudinal Strain in Predicting All-Cause Mortality among Stable Hemodialysis Patients with Preserved Left Ventricular Ejection Fraction

Using a speckle-tracking echocardiography (STE), we recently demonstrated that a left ventricular (LV) global longitudinal strain (GLS) ≥ −15% and the serum cardiac troponin T (cTnT) concentration are associated with mortality in stable hemodialysis patients with preserved LV ejection fraction (LVEF). In this study, we explored the relationship between cTnT and echocardiographic parameters and evaluated whether the prognostic value provided by cTnT is independent of a GLS ≥ −15% and vice versa. Eighty-eight stable hemodialysis patients with preserved LVEF were followed for 31 months. STE studies and measurements of cTnT were performed at baseline. CTnT concentration had a modest correlation with GLS (r s = 0.44; P < 0.001) but had a weak or nonsignificant correlation with other echocardiographic parameters. Adjusting for clinical parameters, hazard ratios for each increase of 0.01 ng/mL in cTnT, and a GLS ≥ −15% on mortality were 1.13 (P = 0.009) and 3.09 (P = 0.03) without significant interaction between cTnT and GLS ≥ −15%. In addition, an increased cTnT concentration, a GLS ≥ −15%, or their combination showed significant additional predictive value for mortality when included in models consisting of clinical parameters. Therefore, both cTnT and a GLS ≥ −15% are independent predictors of mortality and are useful for risk stratification.
Computing the Stretch of an Embedded Graph

Let $G$ be a graph embedded in an orientable surface $\Sigma$, possibly with edge weights, and denote by ${\rm len}(\gamma)$ the length (the number of edges or the sum of the edge weights) of a cycle $\gamma$ in $G$. The stretch of a graph embedded on a surface is the minimum of ${\rm len}(\alpha)\cdot {\rm len}(\beta)$ over all pairs of cycles $\alpha$ and $\beta$ that cross exactly once. We provide two algorithms to compute the stretch of an embedded graph, each based on a different principle. The first algorithm is based on surgery and computes the stretch in time $O(g^4 n \log n)$ with high probability, or in time $O(g^4 n \log^2 n)$ in the worst case, where $g$ is the genus of the surface $\Sigma$ and $n$ is the number of vertices in $G$. The second algorithm is based on using a short homology basis and computes the stretch in time $O(n^2\log n + n^2g + ng^3)$.
The Control of Mimicry by Eye Contact Is Mediated by Medial Prefrontal Cortex

Spontaneous mimicry of other people's actions serves an important social function, enhancing affiliation and social interaction. This mimicry can be subtly modulated by different social contexts. We recently found behavioral evidence that direct eye gaze rapidly and specifically enhances mimicry of intransitive hand movements (Wang et al., 2011). Based on past findings linking medial prefrontal cortex (mPFC) to both eye contact and the control of mimicry, we hypothesized that mPFC might be the neural origin of this behavioral effect. The present study aimed to test this hypothesis. During functional magnetic resonance imaging (fMRI) scanning, 20 human participants performed a simple mimicry or no-mimicry task, as previously described (Wang et al., 2011), with direct gaze present on half of the trials. As predicted, fMRI results showed that performing the task activated mirror systems, while direct gaze and inhibition of the natural tendency to mimic both engaged mPFC. Critically, we found an interaction between mimicry and eye contact in mPFC, superior temporal sulcus (STS) and inferior frontal gyrus. We then used dynamic causal modeling to contrast 12 possible models of information processing in this network. Results supported a model in which eye contact controls mimicry by modulating the connection strength from mPFC to STS. This suggests that mPFC is the originator of the gaze–mimicry interaction and that it modulates sensory input to the mirror system. Thus, our results demonstrate how different components of the social brain work together to on-line control mimicry according to the social context.
Human Perceptions of Climate Change

This paper presents an interactive simulation of the effects of emissions and absorptions of anthropogenic carbon dioxide (CO2) in the atmosphere. The interactive simulation based on the “bathtub” metaphor, was built using the Dynamic Integrated Climate Economy model (DICE)-1992. The interactive tool allows participants to make decisions on the anthropogenic CO2 emissions, observe the consequences of the decisions and try new decisions. In a laboratory experiment, we tested the participants’ ability to control the CO2 concentration to a realistic amount in the atmosphere over a period of 100 to 200 years. Participants worked on one of two extreme conditions: one rapid, where transfer rate of carbon dioxide was 1.6% per year with CO2 emission decisions made every 2 years, and other slow, where transfer rate of carbon dioxide was 1.2% per year with CO2 emission decisions made every 4 years. Due to human incapacity to handle feedback delays and their use of faulty heuristics, we expected participants to find the slow condition harder to control as compared to the rapid condition. Results show that participants had more difficulty achieving control of CO2 concentration to goal in face of slower dynamics than rapid dynamics. Implications and future of our research findings are discussed.
Patient, physician, and family member understanding of living wills.

This study examines understanding of living wills by patients, family members, and physicians. Questionnaires were used to examine whether each cohort understood patients' living wills regarding endotracheal intubation and cardiopulmonary rescuscitation (CPR). Of 4,800 patients admitted during the study period, 206 reported having living wills, all of which precluded intubation and CPR for "terminal conditions. " Of 140 admitted to the general hospital wards, 17 (12%) wanted their living wills to preclude intubation/mechanical ventilation and 12 (8.6%) did not want resuscitation under any circumstances. Seven of 120 (6%) physicians and 4 of 108 family members would not intubate or perform CPR even if there was a chance of recovery. Of 88 patients with complete data (including physicians and family members), 29 (33%) wanted their living wills to block intubation/mechanical ventilation only if they were deemed terminal and 46 (52%) wanted the living will to block intubation even if there was a 10% chance of recovery. Thirteen (15%) wanted to block intubation even if the chance of recovery was > or = 50. Results were similar for wishes regarding CPR. These data suggest substantial differences of patient, physician, and family member understanding of living wills. Living wills did not reflect fully patients' expectations of receiving (or not receiving) life-sustaining modalities.
Therapeutic Induction of Arteriogenesis in Hypoperfused Rat Brain Via Granulocyte-Macrophage Colony-Stimulating Factor

Background—Colony-stimulating factors (CSFs) have been shown to effectively induce arteriogenesis in the hindlimb. Moreover, clinical trials demonstrated positive effects of CSFs on arteriogenesis in patients with coronary artery disease. However, patients with cerebrovascular disease have not yet profited from treatments aimed at the growth of brain vessels. Thus far, angiogenesis studies have failed to demonstrate improvement of stroke outcome. Arteriogenesis differs from angiogenesis in that it substitutes arterial collaterals for the occluded artery. Methods and Results—We tested in a novel brain arteriogenesis rat model (occlusion of vertebral plus left carotid artery [3-VO]) the application of CSFs or saline over 7 or 21 days. On 3-VO postmortem, latex perfusion demonstrated a time- and treatment-dependent arteriogenesis of the posterior cerebral artery (PCA). In saline-treated animals, the PCA diameter increased by 39%; in granulocyte-macrophage (GM)-CSF-treated animals, this increase was significantly faster (72% after 1 week). Functionally, saline-treated animals exhibited a decline of CO2 reactivity (mm Hg) from 1.48% to 0.1% compared with GM-CSF–treated animals (1.43% arterial pCo2 change after 1 week). This difference remained significant after 3 weeks. This functional improvement correlated with increased numbers of CD68-positive macrophages in histological sections of the PCA in GM-CSF–treated animals and only a few macrophages in saline-treated animals. Conclusions—To the best of our knowledge, this is the first report of stimulation of arteriogenesis in the brain. The subcutaneous application of GM-CSF led to functional improvement of brain hemodynamic parameters.
When Desire Collides with Reason: Functional Interactions between Anteroventral Prefrontal Cortex and Nucleus Accumbens Underlie the Human Ability to Resist Impulsive Desires

Human decisions are guided by “desire” or “reason,” which control actions oriented toward either proximal or long-term goals. Here we used functional magnetic resonance imaging to assess how the human brain mediates the balance between proximal reward desiring and long-term goals, when actions promoting a superordinate goal preclude exploitation of an immediately available reward option. Consistent with the view that the reward system interacts with prefrontal circuits during action control, we found that behavior favoring the long-term goal, but counteracting immediate reward desiring, relied on a negative functional interaction of anteroventral prefrontal cortex (avPFC) with nucleus accumbens (Nacc) and ventral tegmental area. The degree of functional interaction between avPFC and Nacc further predicted behavioral success during pursuit of the distal goal, when confronted with a proximal reward option, and scaled with interindividual differences in trait impulsivity. These findings reveal how the human brain accomplishes voluntary action control guided by “reason,” suggesting that inhibitory avPFC influences Nacc activity during actions requiring a restraint of immediate “desires. ”
Psychological Predictors of Mental Toughness in Elite Tennis: An Exploratory Study in Learned Resourcefulness and Competitive Trait Anxiety

The purpose of this study was to examine the extent to which two constructs, learned resourcefulness and competitive trait anxiety, measured by the Self-Control Schedule and Sports Competition Anxiety Test, respectively, predicted mental toughness on the Sports Mental Toughness Questionnaire among male and female elite tennis players. The participants included two NCAA Division 1 (U.S.) intercollegiate tennis teams comprising eight male (M age = 19.4 yr., SD = 1.2) and eight female (M age = 20.9 yr., SD = 1.4) players and their respective head coaches (N = 2, M age = 28 yr., SD = 5.7). Results of regression analyses indicated that learned resourcefulness was the primary predictor of athlete self-rated mental toughness and that competitive trait anxiety was relatively unrelated to coach and athlete-rated mental toughness. The positive significant relationship between mental toughness and learned resourcefulness suggests that the latter may be an integral component of mental toughness, at least among elite tennis players. Further research is needed to examine related components of mental toughness, including learned resourcefulness, and to determine the effectiveness of interventions that increase mental toughness to optimal levels, particularly as a function of sport type.
Dynamic fuzzy cellular admission control

Quality of Service (QoS) is a mobile network challenge. An efficient Call Admission Control (CAC) is the first step towards QoS guaranty. Some CACs use resource reservation and network diagnosis to ensure QoS. The CAC may block lower-priority applications using static thresholds when the network utilization is high. Such static strategy does not allow the maximum utilization of the network resources under certain traffic conditions. This paper proposes CAC-RDF, a dynamic call blocking scheme has been developed. Fuzzy logic has been chosen to deal with the network congestion level. CAC-RDF improves the network resources distribution while ensuring adequate QoS.
Correlation between miRNAs and target genes in response to Campylobacter jejuni inoculation in chicken

Abstract Campylobacter jejuni (C. jejuni) is one of the main causes of human campylobacteriosis worldwide. Chicken is the main reservoir of C. jejuni. The cecum is the primary site of C. jejuni colonization. Our previous study has shown that the CLOCK gene is important to regulate the response to C. jejuni inoculation and has a cross‐talking with immune‐related genes. Correlation networks between the CLOCK gene and microRNAs (miRNAs) play vital roles in colorectal tumorigenesis. MiRNAs play crucial roles in bacterial invasion through regulating multiple target genes. To study the regulatory correlation between miRNAs and target genes, 5 miRNAs that regulate the expression of the CLOCK gene (CLOCK‐interacted miRNAs) and 5 immune‐related target genes predicted through Targetscan and miRDB were selected to analyze the expression pattern in chicken ceca at 4, 8, 12, 16, 20, and 24 h post C. jejuni inoculation using quantitative PCR. The results showed that the expression of gga‐miR‐148a, gga‐miR‐1416‐5p, gga‐miR‐30b, and gga‐miR‐30c were significantly up‐regulated at 8 hpi, and gga‐miR‐30a‐5p, gga‐miR‐30b, and gga‐miR‐30c were significantly down‐regulated at 24 hpi, and gga‐miR‐1416‐5p was significantly down‐regulated at 20 hpi (P < 0.05). The expression levels of BCL9 (B‐cell CLL/lymphoma 9), STX16 (syntaxin16), IL4R (interleukin 4 receptor), and IRF4 (interferon regulatory factor 4) genes were significantly up‐regulated at 8 hpi, while SOCS3 (suppressor of cytokine signaling 3) was significantly down‐regulated. Furthermore, the expression pattern of gga‐miR‐30b was consistent with gga‐miR‐30c. Both miRNAs and mRNAs showed an oscillation expression pattern in both inoculated and non‐inoculated groups. The regulatory direction of SOCS3 was contrary to those of gga‐miR‐148a, gga‐miR‐1416‐5p, gga‐miR‐30b, and gga‐miR‐30c at 8 hpi. In summary, MiR‐30 and the miR‐148/miR‐152 family time‐dependently regulate the response to C. jejuni inoculation in chicken ceca. BCL9, STX16, IRF4, and IL4R play important roles in the response to C. jejuni inoculation. The CLOCK gene‐interacted miRNA and immune‐related target genes had a correlative response to C. jejuni inoculation. The SOCS3 gene interacts with gga‐miR‐30b, gga‐miR‐30c, gga‐miR‐148a, and gga‐miR‐1416‐5p in response to C. jejuni inoculation at 8 hpi. The correlations between CLOCK‐interacted miRNA and immune‐related target genes play vital roles in the response to C. jejuni inoculation. The results herein will lay the foundation for further study of a regulatory mechanism of chicken miRNAs and their target genes in response to C. jejuni inoculation.
Genetic analysis and mapping of gene fzp(t) controlling spikelet differentiation in rice

A mutant of spikelet differentiation in rice called frizzle panicle (fzp) was discovered in the progeny of a cross between Oryza sativa ssp. indica cv. V20B and cv. Hua1B. The mutant exhibits normal plant morphology but has apparently fewer tillers. The most striking change in fzp is that its spikelet differentiation is completely blocked, with unlimited subsequent rachis branches generated from the positions where spikelets normally develop in wild-type plants. Genetic analysis suggests that fzp is controlled by a single recessive gene, which is temporarily named fzp(t). Based on its mutant phenotype, fzp(t) represents a key gene controlling spikelet differentiation. Some F2 mutant plants derived from various genetic background appeared as the “middle type”, suggesting that the action of fzp(t) is influenced by the presence of redundant, modifier or interactive genes. By using simple sequence repeat (SSR) markers and bulked segregant analysis (BSA) method, fzp(t) gene was mapped in the terminal region of the long arm of chromosome 7, with RM172 and RM248 on one side, 3.2 cM and 6.4 cM from fzp(t), and RM18 and RM234 on the other side, 23.1 cM and 26.3 cM from fzp(t), respectively. These results will facilitate the positional cloning and function studies of the gene.
PREDICTIVE ROLE OF PERSONALITY TRAITS ON INTERNET ADDICTION

Aiming to develop a model seeking to investigate the direct effects of personality types on internet addiction, this study was set and tested on tertiary level students receiving education within two learning modes: face to face and distance education. The participants of the study, selected through maximum variety method within purposive sampling, included 210 students enrolled on face-to-face and distance education programs of computer programming department. In addition to a personal data form aiming to obtain information on demographic features of the participants, a personality inventory and an Internet addiction scale were utilized to gather data. As an analysis model concurrently exerting both the mediation and direct effects, path analysis with observed variables was utilized in the current study to test the developed model. The findings revealed that while the most powerful predictor variable of internet addiction was conscientiousness, openness to experience was found as the weakest independent variable predictor. Additionally the developed model was observed as valid for both face to face and distance education students.