Miracle-dz/UniFAR-FTUs huggingface dataset:
Risk factors for trachoma in Mali.

OBJECTIVES Prior to commencing a campaign to eliminate blinding trachoma in Mali, a national disease prevalence survey was conducted from March 1996 to June 1997. The prevalence of trachoma was estimated and potential risk factors were studied. METHODS In each of Mali's seven regions (excluding the capital Bamako), a sample of 30 clusters was taken from the general population, in accordance with the principle of probability proportional to the size of the community. All children under 10 years of age were examined. The simplified clinical coding system proposed by the World Health Organization was used. The position of each village was established and subsequently related to the nearest meteorological station. Socioeconomic and environmental information was collected at both village and household level. The mother or caretaker of each child was questioned about availability and use of water for washing the child. At the time of examination, facial cleanliness and the presence of flies on the face were noted. RESULTS A total of 15,187 children under 10 years of age were examined. The prevalence of active trachoma (follicular [TF] or intense trachoma [TI]) was 34.9% (95% CI : 32.3-37.6) and the prevalence of TI was 4.2% (95% CI : 3.5-5.0). Aridity/environmental dryness appears to be a risk factor influencing the current geographical distribution of trachoma. Small villages had considerably higher trachoma prevalence than their larger neighbours. The proximity of a medical centre and the existence of social organizations such as a women's association were associated with lower levels of trachoma. Crowded living conditions increased the risk. Using a monetary marker of wealth, we observed a linear inverse relation between wealth and trachoma prevalence. The presence of a dirty face was strongly associated with trachoma (odds ratio [OR] = 3.67) as was the presence of flies on the child's face (OR = 3.62). Trachoma prevalence increased with distance to a water source. Disease prevalence decreased with a higher frequency of both face washing and bathing. CONCLUSIONS Of all the risk factors examined, facial cleanliness had the strongest association with the prevalence of trachoma. This was followed by the presence of flies on the child's face. Both face washing and bathing showed beneficial effects. Socioeconomic factors such as wealth were significantly explanatory. It is likely that hygiene education and fly control by environmental improvement could have a very significant impact on the prevalence of trachoma in Mali.
The prognostic impact of O6‐Methylguanine‐DNA Methyltransferase (MGMT) promotor hypermethylation in esophageal adenocarcinoma

Promotor hypermethylation is a common event in human cancer. O6‐Methylguanine‐DNA Methyltransferase (MGMT) is a gene involved in DNA repair, which is methylated in a variety of cancer types. In colorectal cancer and lung cancer, hypermethylation of MGMT has been correlated with p53 mutation. In the present study, 132 samples of esophageal adenocarcinoma and 58 samples of normal esophageal tissue were investigated for MGMT hypermethylation status by methylation‐specific real‐time PCR and results were correlated to clinicopathological parameters, patient's survival, p53 mutation and expression of p53 protein and MGMT protein. In the carcinomas, hypermethylation of MGMT was found in 63.6% of cases and loss of MGMT protein expression in 48.5% of cases. Furthermore, MGMT hypermethylation was found in 5.7% of normal esophageal smooth muscle tissue, in 20.0% of esophageal squamous epithelium and in 61.5% of nonneoplastic Barrett's mucosa. In the carcinomas, hypermethylation of the MGMT gene was correlated with loss MGMT protein expression (p < 0.0001) and with high tumor differentiation (p = 0.0079). In contrast, no correlation between MGMT hypermethylation, Lauren's classification, WHO classification, tumor size, gender, age, pT category and pN category, and p53 status was found. Neither MGMT hypermethylation nor loss of MGMT protein expression was correlated with patient's survival. In conclusion, MGMT hypermethylation in esophageal adenocarcinoma is a frequent event that is associated with loss of MGMT protein expression but not with patient's outcome. © 2006 Wiley‐Liss, Inc.
Who is publishing in the Journal of Sociology? An analysis of author trends 1965–2008

This paper presents the author characteristics of papers published in The Australian Sociological Association (TASA) journal, the Journal of Sociology (formerly the Australian and New Zealand Journal of Sociology) between 1965 and 2008. The aim of the paper is empirically to identify trends in authorship. The review examines all articles published in the period (excluding book reviews). The rationale of the study is to reveal trends in who publishes in the journal in terms of authors’ academic rank, gender, institution, and country. A table of those who have published the greatest number of papers is also presented. Findings show that over time the gap between the proportion of males and females publishing has closed; more PhD students and research fellows are publishing in the journal in recent decades; the highest proportion of authors consistently come from the Australian National University and The University of Queensland; and most authors are located in Australia. Information such as this can inform editorial practices and serve to inform the membership and readership on the nature of the journal.
Preliminary analysis of immune activation in early onset type 2 diabetes

Introduction First Nations and other Aboriginal children are disproportionately affected by cardiometabolic diseases, including type 2 diabetes (T2D). In T2D, the disruption of insulin signalling can be driven by pro-inflammatory immunity. Pro-inflammatory responses can be fueled by toll-like receptors (TLR) on immune cells such as peripheral blood mononuclear cells (PBMC, a white blood cell population). TLR4 can bind to lipids from bacteria and food sources activating PBMC to produce cytokines tumour necrosis factor (TNF)-α and interleukin (IL)-1β. These cytokines can interfere with insulin signalling. Here, we seek to understand how TLR4 activation may be involved in early onset T2D. We hypothesized that immune cells from youth with T2D (n=8) would be more reactive upon TLR4 stimulation relative to cells from age and body mass index (BMI)-matched controls without T2D (n=8). Methods Serum samples were assayed for adipokines (adiponectin and leptin), as well as cytokines. Freshly isolated PBMC were examined for immune reactivity upon culture with TLR4 ligands bacterial lipopolysaccharide (LPS, 2 and 0.2 ng/ml) and the fatty acid palmitate (200 µM). Culture supernatants were evaluated for the amount of TNF-α and IL-1β produced by PBMC. Results Youth with T2D displayed lower median serum adiponectin levels compared to controls (395 vs. 904 ng/ml, p<0.05). PBMC isolated from youth with and without T2D produced similar levels of TNF-α and IL-1β after exposure to the higher LPS concentration. However, at the low LPS dose the T2D cohort exhibited enhanced IL-1β synthesis relative to the control cohort. Additionally, exposure to palmitate resulted in greater IL-1β synthesis in PBMCs isolated from youth with T2D versus controls (p<0.05). These differences in cytokine production corresponded to greater monocyte activation in the T2D cohort. Conclusion These preliminary results suggest that cellular immune responses are exaggerated in T2D, particularly with respect to IL-1β activity. These studies aim to improve the understanding of the biology behind early onset T2D and its vascular complications that burden First Nations people.
RFID-based Ubiquitous Learning Environment for Outdoor Learning

Many issues have been identified in outdoor teaching, especially in places that lack the capacity to effectively present information. This study proposes an environment of ubiquitous learning with educational resources (EULER) based on radio frequency identification (RFID), the Internet and ubiquitous computing technologies to resolve such issues. A case study of natural science learning is conducted in classrooms and at the Guandu Nature Park in Taiwan. The results of evaluation show that the proposed EULER significantly improves student motivation and learning.
Dual-Wavelength Single-Longitudinal-Mode Tm-Doped Fiber Laser Using PM-CMFBG

We have demonstrated a dual-wavelength thulium-doped fiber laser with single-longitudinal-mode (SLM) operation at ~2-μm region. A polarization-maintaining chirped Moiré fiber Bragg grating was employed as a polarization-dependent narrow-band filter, to suppress multilongitudinal-mode oscillation. Single-and dual-wavelength switchable operation was achieved by simply adjusting the polarization controller. We also showed that the laser lines retained SLM operation with the additional benefit of single polarization. Meanwhile, the dependence of each laser wavelength on the pump power was also investigated in detail.
Spectral Analysis of Markov Kernels and Application to the Convergence Rate Of Discrete Random Walks

Let {X n } n∈ℕ be a Markov chain on a measurable space with transition kernel P, and let The Markov kernel P is here considered as a linear bounded operator on the weighted-supremum space associated with V. Then the combination of quasicompactness arguments with precise analysis of eigenelements of P allows us to estimate the geometric rate of convergence ρ V (P) of {X n } n∈ℕ to its invariant probability measure in operator norm on A general procedure to compute ρ V (P) for discrete Markov random walks with identically distributed bounded increments is specified.
Social and moral norm differences among Portuguese 1st and 6th year medical students towards their intention to comply with hand hygiene

This study examines social and moral norms towards the intention to comply with hand hygiene among Portuguese medical students from 1st and 6th years (N = 175; 121 from the 1st year, 54 from the 6th year). The study extended the Theory of Planned Behaviour theoretical principles and hypothesised that both subjective and moral norms will be the best predictors of 1st and 6th year medical students’ intention to comply with hand hygiene; however, these predictors ability to explain intention variance will change according to medical students’ school year. Results indicated that the subjective norm, whose referent focuses on professors, is a relevant predictor of 1st year medical students' intention, while the subjective norm that emphasises the relevance of colleagues predicts the intentions of medical students from the 6th year. In terms of the moral norm, 6th year students' intention is better predicted by a norm that interferes with compliance; whereas intentions from 1st year students are better predicted by a norm that favours compliance. Implications of the findings highlight the importance of role models and mentors as key factors in teaching hand hygiene in medical undergraduate curricula.
Enabling Lightweight Transactions with Precision Time

Distributed transactional storage is an important service in today's data centers. Achieving high performance without high complexity is often a challenge for these systems due to sophisticated consistency protocols and multiple layers of abstraction. In this paper we show how to combine two emerging technologies---Software-Defined Flash (SDF) and precise synchronized clocks---to improve performance and reduce complexity for transactional storage within the data center. We present a distributed transactional system (called MILANA) as a layer above a durable multi-version key-value store (called SEMEL) for read-heavy workloads within a data center. SEMEL exploits write behavior of SSDs to maintain a time-ordered sequence of versions for each key efficiently and durably. MILANA adds a variant of optimistic concurrency control above SEMEL's API to service read requests from a consistent snapshot and to enable clients to make fast local commit or abort decisions for read-only transactions. Experiments with the prototype reveal up to 43% lower transaction abort rates using IEEE Precision Time Protocol (PTP) vs. the standard Network Time Protocol (NTP). Under the Retwis benchmark, client-local validation of read-only transactions yields a 35% reduction in latency and 55% increase in transaction throughput.
Backward Error and Condition of Polynomial Eigenvalue Problems

We develop normwise backward errors and condition numbers for the polynomial eigenvalue problem. The standard way of dealing with this problem is to reformulate it as a generalized eigenvalue problem (GEP). For the special case of the quadratic eigenvalue problem (QEP), we show that solving the QEP by applying the QZ algorithm to a corresponding GEP can be backward unstable. The QEP can be reformulated as a GEP in many ways. We investigate the sensitivity of a given eigenvalue to perturbations in each of the GEP formulations and identify which formulations are to be preferred for large and small eigenvalues, respectively.
Arterial Surgery

literature (17 out of the first 25 references are to journals printed outside of this hemisphere), the reader is led to expect a fairly definitive treatment. Unfortunately, this is not the case. As early as page nine, Catsch states that, "with almost the sole exception of 238U, the toxicity of internally deposited radiometals is ultimately dependent almost entirely upon the ionizing radiation emitted, and not upon their chemical properties. " Once this is stated, the words appear to be forgotten, and nowhere in the book is there a listing of the half-lives of the principal radiometals, their emissions, or sample calculations for determining the radiation dose they deliver internally. The elimination of the radiometals is noted to be complex, and on page five Catsch states that often, ". it follows a multiexponential formulation (or approaches a power function). " Yet not one of the figures showing radiometal distribution or excretion are analyzed in terms of exponentials or power functions. The opportunity for quantitation lost, the book becomes wordy without being truly definitive. Catsch does give a good survey of the chelating agents, particularly the polyaminopolycarboxylic acids of which ethylene-diamine tetraacetic acid (EDTA) and diethylene triamine-pentaacetic acid (DTPA) are examples. Yet the modalities of dialysis and interruption of the enterohepatic circulation are neglected. If the volume had been entitled, Use of Chelating Agents In Radiometal Mobilization, it would have given a better idea of the contents. For the theory and therapeutic use of the polyaminopolycarboxylic acids as chelating agents, the book will find use. In terms of a quantitative approach to radioactive metal mobilization, it leaves several important voids unfilled. RICHARD P. SPENCER
Chemical disposition of boron in animals and humans.

Elemental boron was isolated in 1808. It typically occurs in nature as borates hydrated with varying amounts of water. Important compounds are boric acid and borax. Boron compounds are also used in the production of metals, enamels, and glasses. In trace amounts, boron is essential for the growth of many plants, and is found in animal and human tissues at low concentrations. Poisoning in humans has been reported as the result of accidental ingestion or use of large amounts in the treatment of burns. Boron as boric acid is fairly rapidly absorbed and excreted from the body via urine. The half-life of boric acid in humans is on the order of 1 day. Boron does not appear to accumulate in soft tissues of animals, but does accumulate in bone. Normal levels of boron in soft tissues, urine, and blood generally range from less than 0.05 ppm to no more than 10 ppm. In poisoning incidents, the amount of boric acid in brain and liver tissue has been reported to be as high as 2000 ppm. Recent studies at the National Institute of Environmental Health Sciences have indicated that boron may contribute to reduced fertility in male rodents fed 9000 ppm of boric acid in feed. Within a few days, boron levels in blood and most soft tissues quickly reached a plateau of about 15 ppm. Boron in bone did not appear to plateau, reaching 47 ppm after 7 days on the diet. Cessation of exposure to dietary boron resulted in a rapid drop in bone boron. (ABSTRACT TRUNCATED AT 250 WORDS)
New insights into Hoogsteen base pairs in DNA duplexes from a structure-based survey

Hoogsteen (HG) base pairs (bps) provide an alternative pairing geometry to Watson–Crick (WC) bps and can play unique functional roles in duplex DNA. Here, we use structural features unique to HG bps (syn purine base, HG hydrogen bonds and constricted C1′–C1′ distance across the bp) to search for HG bps in X-ray structures of DNA duplexes in the Protein Data Bank. The survey identifies 106 A•T and 34 G•C HG bps in DNA duplexes, many of which are undocumented in the literature. It also uncovers HG-like bps with syn purines lacking HG hydrogen bonds or constricted C1′–C1′ distances that are analogous to conformations that have been proposed to populate the WC-to-HG transition pathway. The survey reveals HG preferences similar to those observed for transient HG bps in solution by nuclear magnetic resonance, including stronger preferences for A•T versus G•C bps, TA versus GG steps, and also suggests enrichment at terminal ends with a preference for 5′-purine. HG bps induce small local perturbations in neighboring bps and, surprisingly, a small but significant degree of DNA bending (∼14°) directed toward the major groove. The survey provides insights into the preferences and structural consequences of HG bps in duplex DNA.
Low power aging-aware register file design by duty cycle balancing

The degradation of CMOS devices over the lifetime can cause the severe threat to the system performance and reliability at deep submicron semiconductor technologies. The negative bias temperature instability (NBTI) is among the most important sources of the aging mechanisms. Applying the traditional guardbanding technique to address the decreased speed of devices is too costly. Due to presence of the narrow-width values, integer register files in high-performance microprocessors suffer a very high NBTI stress. In this paper, we propose an aging-aware register file (AARF) design to combat the NBTI-induced aging in integer register files. The proposed AARF design can mitigate the negative aging effects by balancing the duty cycle ratio of the internal bits in register files. By gating the leading bits of the narrow-width values during the register accesses, our AARF can also achieve a significantly power reduction, which will further reduce the temperature and NBTI degradation of integer register files. Our experimental results show that AARF can effectively reduce the NBTI stress with a 36.9% power saving for integer register files.
Multi‐site placebo‐controlled randomised clinical trial to assess protection following oral immunisation with inactivated non‐typeable Haemophilus influenzae in chronic obstructive pulmonary disease

Previous studies identified factors that modify response to an oral non‐typeable Haemophilus influenzae (NTHi) vaccine in chronic obstructive pulmonary disease (COPD): severe COPD, moderate–severe exacerbations as end‐point and a threshold prevalence of NTHi in the study population. More data are needed to confirm parameters that influence clinical outcomes.
National Multicenter Study of Predictors and Outcomes of Bacteremia upon Hospital Admission Caused by Enterobacteriaceae Producing Extended-Spectrum β-Lactamases

ABSTRACT Extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae are pathogens that may lead to a spectrum of clinical syndromes. We aimed to identify predictors and outcomes of ESBL bacteremia upon hospital admission (UHA) in a nationwide prospective study. Thus, a multicenter prospective study was conducted in 10 Israeli hospitals. Adult patients with bacteremia due to Enterobacteriaceae diagnosed within 72 h of hospitalization were included. Patients with ESBL producers (cases) were compared to those with non-ESBL producers (controls), and a 1:1 ratio was attempted in each center. A case-control study to identify predictors and a cohort study to identify outcomes were conducted. Bivariate and multivariate logistic regressions were used for analyses. Overall, 447 patients with bacteremia due to Enterobacteriaceae were recruited: 205 cases and 242 controls. Independent predictors of ESBL were increased age, multiple comorbid conditions, poor functional status, recent contact with health care settings, invasive procedures, and prior receipt of antimicrobial therapy. In addition, patients presenting with septic shock and/or multiorgan failure were more likely to have ESBL infections. Patients with ESBL producers suffered more frequently from a delay in appropriate antimicrobial therapy (odds ratio [OR], 4.7; P, <0.001) and had a higher mortality rate (OR, 3.5; P, <0.001). After controlling for confounding variables, both ESBL production (OR, 2.3; P, 9.1) and a delay in adequate therapy (OR, 0.05; P, 0.001) were significant predictors for mortality and other adverse outcomes. We conclude that among patients with bacteremia due to Enterobacteriaceae UHA, those with ESBL producers tend to be older and chronically ill and to have a delay in effective therapy and severe adverse outcomes. Efforts should be directed to improving the detection of patients with ESBL bacteremia UHA and to providing immediate appropriate therapy.
Exploring Cyber-Bullying: a Retrospective Study of First Year University Students

This was a retrospective study of cyber-bullying. Students enrolled in a first year course were selected to provide opinions on the issue of cyber-bullying as it pertained to social networking sites and young people. A mixed methods approach was applied to this study. Questionnaires provided quantitative data, and a focus group provided data for qualitative analysis. It was evident that students felt that cyber-bullying was not as prevalent as traditional bullying; however, it was identified as a serious issue. In relation to gender, traditional bullying was considered to be a problem for boys, more than cyber-bullying, whereas for girls cyber-bullying was considered to be a problem, more than traditional bullying. Social networking sites, solely, were not common tools used in cyber-bullying. Generally cell phones or a combination of cell phones and social networking sites were used. It was determined the age group at most risk from cyber-bullying to be early high school. Raising awareness of cyber-bullying was considered essential for prevention.
TLR2, TLR4 and CD14 Recognize Venom-Associated Molecular Patterns from Tityus serrulatus to Induce Macrophage-Derived Inflammatory Mediators

Scorpion sting-induced human envenomation provokes an intense inflammatory reaction. However, the mechanisms behind the recognition of scorpion venom and the induction of mediator release in mammalian cells are unknown. We demonstrated that TLR2, TLR4 and CD14 receptors sense Tityus serrulatus venom (TsV) and its major component, toxin 1 (Ts1), to mediate cytokine and lipid mediator production. Additionally, we demonstrated that TsV induces TLR2- and TLR4/MyD88-dependent NF-κB activation and TLR4-dependent and TLR2/MyD88-independent c-Jun activation. Similar to TsV, Ts1 induces MyD88-dependent NF-κB phosphorylation via TLR2 and TLR4 receptors, while c-Jun activation is dependent on neither TLR2 nor TLR4/MyD88. Therefore, we propose the term venom-associated molecular pattern (VAMP) to refer to molecules that are introduced into the host by stings and are recognized by PRRs, resulting in inflammation.