Miracle-dz/UniFAR-FTUs huggingface dataset:
The Bone Morphogenetic Protein Roof Plate Chemorepellent Regulates the Rate of Commissural Axonal Growth

Commissural spinal axons extend away from the roof plate (RP) in response to a chemorepellent mediated by the bone morphogenetic proteins (BMPs). Previous studies have focused on the ability of commissural axons to translate a spatial gradient of BMPs into directional information in vitro. However, a notable feature of this system in vivo is that the gradient of BMPs is thought to act from behind the commissural cell bodies, making it possible for the BMPs to have a continued effect on commissural axons as they grow away from the RP. Here, we demonstrate that BMPs activate the cofilin regulator Lim domain kinase 1 (Limk1) to control the rate of commissural axon extension in the dorsal spinal cord. By modulating Limk1 activity in both rodent and chicken commissural neurons, the rate of axon growth can either be stalled or accelerated. Altering the activation state of Limk1 also influences subsequent guidance decisions: accelerated axons make rostrocaudal projection errors while navigating their intermediate target, the floor plate. These results suggest that guidance cues can specify information about the rate of growth, to ensure that axons reach subsequent signals either at particular times or speeds during development.
The repeatability of fluctuating asymmetry: a revision and extension

Fluctuating asymmetry (FA) is an imperfect measure of the developmental stability of an individual. Estimates of the heritability of FA will underestimate the heritability of developmental stability; the extent of this bias can be estimated and corrected by estimating the repeatability of developmental stability. This note corrects an error in a previous derivation of this repeatability using the absolute value of the difference between sides as the measure of FA, and derives the repeatability of developmental stability for another common measure of FA, the variance among sides within an individual.
Petrology of silicate inclusions in the Sombrerete ungrouped iron meteorite: Implications for the origins of IIE‐type silicate‐bearing irons

Abstract— The petrography and mineral and bulk chemistries of silicate inclusions in Sombrerete, an ungrouped iron that is one of the most phosphate‐rich meteorites known, was studied using optical, scanning electron microscopy (SEM), electron microprobe analysis (EMPA), and secondary ion mass spectrometry (SIMS) techniques. Inclusions contain variable proportions of alkalic siliceous glass (˜69 vol% of inclusions on average), aluminous orthopyroxene (˜9%, Wo1–4Fs25–35, up to ˜3 wt% Al), plagioclase (˜8%, mainly An70–92), Cl‐apatite (˜7%), chromite (˜4%), yagiite (˜1%), phosphate‐rich segregations (˜1%), ilmenite, and merrillite. Ytterbium and Sm anomalies are sometimes present in various phases (positive anomalies for phosphates, negative for glass and orthopyroxene), which possibly reflect phosphate‐melt‐gas partitioning under transient, reducing conditions at high temperatures. Phosphate‐rich segregations and different alkalic glasses (K‐rich and Na‐rich) formed by two types of liquid immiscibility. Yagiite, a K‐Mg silicate previously found in the Colomera (IIE) iron, appears to have formed as a late‐stage crystallization product, possibly aided by Na‐K liquid unmixing. Trace‐element phase compositions reflect fractional crystallization of a single liquid composition that originated by low‐degree (˜4–8%) equilibrium partial melting of a chondritic precursor. Compositional differences between inclusions appear to have originated as a result of a “filter‐press differentiation” process, in which liquidus crystals of Cl‐apatite and orthopyroxene were less able than silicate melt to flow through the metallic host between inclusions. This process enabled a phosphoran basaltic andesite precursor liquid to differentiate within the metallic host, yielding a dacite composition for some inclusions. Solidification was relatively rapid, but not so fast as to prevent flow and immiscibility phenomena. Sombrerete originated near a cooling surface in the parent body during rapid, probably impact‐induced, mixing of metallic and silicate liquids. We suggest that Sombrerete formed when a planetesimal undergoing endogenic differentiation was collisionally disrupted, possibly in a breakup and reassembly event. Simultaneous endogenic heating and impact processes may have widely affected silicate‐bearing irons and other solar system matter.
Identity, Stress, and Resilience in Lesbians, Gay Men, and Bisexuals of Color

The author addresses two issues raised in Moradi, DeBlaere, and Huang’s Major Contribution to this issue: the intersection of racial/ethnic and lesbian, gay, and bisexual (LGB) identities and the question of stress and resilience. The author expands on Moradi et al.’s work, hoping to encourage further research. On the intersection of identities, the author notes that LGB identities among people of color have been construed as different from the identities of White LGB persons, purportedly because of an inherent conflict between racial/ethnic and gay identities.The author suggests that contrary to this, LGB people of color can have positive racial/ethnic and LGB identities. On the question of stress and resilience, hypotheses have suggested that compared with White LGB individuals, LGB people of color have both more stress and more resilience. The author addresses the competing hypotheses within the larger perspective of minority stress theory, noting that the study of stress and resilience among LGB people of color is relevant to core questions about social stress as a cause of mental disorders.
"Moral Influence" in Asia: Political Practice and Electoral Corruption in the Spanish Philippines

Proceeding from a microhistory of local elections at the end of the nineteenth century in one municipality, this article traces the mechanisms of representation and exercise of local power in the Spanish Philippines. Within the colonial apparatus the municipal sphere was one of the few areas of tangible power for the principalía (indigenous elites). The local elites, who were selected by colonial authorities based on political, economic, and religious criteria, played an important role in the fealties and resistances in the colony. This article examines the significance of the Maura Law, or the electoral reforms of 1893, and the obstacles encountered in the eradication of electoral abuse—"moral influence"—that colonial authorities, through action or inaction, had promoted over the years.
Individualized Estimation of the Central Aortic Blood Pressure Waveform: A Comparative Study

This paper presents a comparative study on the relative performance of alternative strategies for estimating an individualized central aortic blood pressure (BP) waveform. Based on the transmission line representation of the central aortic-radial arterial line, a fully individualized (ITF 1), two partially individualized (ITF 2 and ITF 3), and a fully nonindividualized (NITF) transfer functions (i.e., frequency-dependent central aortic-radial BP relationships) were constructed using experimental data collected from nine swine subjects. The central aortic BP waveforms estimated by these transfer functions were compared against their measured gold standards, with the root-mean-squared waveform error and the absolute errors associated with systolic and pulse pressures as performance measures. Overall, the advantage of the individualized over the nonindividualized approach was modest but significant. The superiority of the individualized approach to its nonindividualized counterpart was increasingly pronounced under nonnominal or extreme physiologic conditions, as the subject's pulse transit time deviated from the averaged nominal value. The results suggest that the use of a fully individualized transfer function (ITF 1) is strongly recommended for nonnominal physiologic conditions, whereas a partially (ITF 2 and ITF 3) or even fully nonindividualized transfer function (NITF) may also yield acceptable performance under nominal physiologic conditions.
The effect of music therapy on anxiety in patients who are terminally ill.

BACKGROUND The literature supporting the use of music therapy in palliative care is growing. However, the number of quantitative research studies investigating the use of music therapy in palliative care, and specifically anxiety, is limited. OBJECTIVE The aim of this research project was to examine the effectiveness of a single music therapy session in reducing anxiety for terminally ill patients. DESIGN A randomized-controlled design was implemented and the following hypotheses tested. There will be a significant difference between the experimental and control groups on anxiety levels as demonstrated by the anxiety measurement of the Edmonton Symptom Assessment System (ESAS), and heart rate. The experimental group received a single music therapy intervention and the control group received a volunteer visit. SETTING/SUBJECTS Twenty-five participants with end-stage terminal disease receiving inpatient hospice services were recruited. RESULTS The first hypothesis was supported. Results demonstrated a significant reduction in anxiety for the experimental group on the anxiety measurement of the ESAS (p = 0.005). A post hoc analysis found significant reductions in other measurements on the ESAS in the experimental group, specifically pain (p = 0.019), tiredness (p = 0.024) and drowsiness (p = 0.018). The second hypothesis was not supported. CONCLUSIONS The study supports the use of music therapy to manage anxiety in terminally ill patients. Further studies are required to examine the effect of music therapy over a longer time period, as well as addressing other symptom issues.
Electroconvulsive Therapy Practice in Poland

The aim of the study reported herein was to determine the characteristics of electroconvulsive therapy (ECT) practice in Poland. Method: A 20-item questionnaire was sent to all Polish inpatient psychiatric facilities including all academic centers, general hospital psychiatric wards and psychiatric institutions. Results: Each of the 58 departments (100%) replied by mail or by phone. A total of 25 departments indicated the use of ECT, but only in 20 departments was it administered regularly. Altogether, 435 patients (0.79% of all inpatients) were treated with ECT in Poland during 2005. The main indications of ECT were affective disorders. Bitemporal electrode placement was used twice or 3 times a week in each setting. Anesthesia was usually induced either with thiopental or propofol. The wide variations in the investigations for pre-ECT evaluation reflect the lack of a generally accepted ECT protocol in Poland. Conclusion: The rate of ECT use in Poland is among the lowest in the Central-East European region, which raises the possibility that many patients who otherwise would greatly benefit from ECT do not receive this treatment.
The validity of the RILE left–right index as a measure of party policy

The RILE index of the manifesto dataset is a popular but controversial estimate of parties’ left–right positions. It has been thoroughly criticized, yet a basic question of its validity has not been addressed. In the current article I argue that for the index to be valid, patterns of association presumed by the logic of the index must be present in the data used to calculate it. I apply canonical correlation analysis (CCA) to test these associations within and between the sets of variables that form the left–right (RILE) index, concluding that for countries which have not experienced a communist past the relationship is present, although substantively weak. More important, however, is that for post-communist countries the required associations in the data are clearly not there. The RILE index is therefore an invalid measure of left–right position for this set of countries.
Cow's milk protein intolerance and chronic constipation in children

Cow's milk protein (CMP) allergy was investigated in 25 children (age‐range 3 months to 11 years) with chronic constipation. A diagnosis of constipation was made on the basis of a history of painful elimination of hard stools for at least 1 month, whether or not associated with a reduced frequency of stools or soiling. The children were evaluated using clinical parameters and the following laboratory tests: total serum immunoglobulin E (IgE); specific IgE (radioallergosorbent test [RAST]) for whole cow's milk, α‐lactoalbumin, β‐lactoglobulin, and a food group; and skin‐prick tests with whole milk, α‐lactoalbumin, β‐lactoglobulin, and casein. Following the evaluation, the children were submitted to a CMP‐free diet for a period of 4 weeks. In seven patients (28%), constipation disappeared during the CMP‐free diet and reappeared within 48–72 h following challenge with cow's milk. In two infants a rectal biopsy revealed allergic colitis and they therefore did not undergo the challenge. High serum levels of total IgE were observed in five of the children who showed a clinical improvement (71%), a positive skin‐test in two (29%), and detectable specific IgE in two (29%). These results suggest that CMP allergy or intolerance should be considered as a cause of chronic refractory constipation in children, although the underlying mechanism still require further investigation.
Taking Comics Seriously: Children’s Periodical Reading in England in the 1990s

Periodicals, that is newspapers, magazines and comics, have always represented a substantial proportion of children’s reading outside school. They have not always been accepted or considered as reading within schools. Martin Coles and Chris Hall here present the results of the most recent survey to shed light on the periodical reading which is actually happening among today’s children. They present some important findings which have the potential to alter significantly the ways teachers see this kind of reading and its possible contribution to the development of literacy.
Potential Signals of Natural Selection in the Top Risk Loci for Coronary Artery Disease: 9p21 and 10q11

Background Coronary artery disease (CAD) is a complex disease and the leading cause of death in the world. Populations of different ancestry do not always share the same risk markers. Natural selective processes may be the cause of some of the population differences detected for specific risk mutations. Objective In this study, 384 single nucleotide polymorphisms (SNPs) located in four genomic regions associated with CAD (1p13, 1q41, 9p21 and 10q11) are analysed in a set of 19 populations from Europe, Middle East and North Africa and also in Asian and African samples from the 1000 Genomes Project. The aim of this survey is to explore for the first time whether the genetic variability in these genomic regions is better explained by demography or by natural selection. Results The results indicate significant differences in the structure of genetic variation and in the LD patterns among populations that probably explain the population disparities found in markers of susceptibility to CAD. Conclusions The results are consistent with potential signature of positive selection in the 9p21 region and of balancing selection in the 9p21 and 10q11. Specifically, in Europe three CAD risk markers in the 9p21 region (rs9632884, rs1537371 and rs1333042) show consistent signals of positive selection. The results of this study are consistent with a potential selective role of CAD in the configuration of genetic diversity in current human populations.
Portraying monsters: framing school bullying through a macro lens

This article critically considers the discourse on school bullying through the conceptual framework of lenses and argues that a macro lens has been utilised by school bullying researchers to bring into focus the characteristics of the individuals involved and the types of actions used. By considering earlier understandings of bullying, the article illustrates how this macro lens has become a metalens through which school bullying is understood. This has had implications for how bullying is understood and addressed, as well as for how vast numbers of school-aged children are perceived and treated. The article argues that the macro lens needs to be replaced with a wide-angle lens, so as to bring the social, institutional and societal contexts into view.
Nonlinear control methods for planar carangiform robot fish locomotion

Considers the design of motion control algorithms for robot fish. We present modeling, control design, and experimental trajectory tracking results for an experimental planar robotic fish system that is propelled using carangiform-like locomotion. Our model for the fish's propulsion is based on quasi-steady fluid flow. Using this model, we propose gaits for forward and turning trajectories and analyze system response under such control strategies. Our models and predictions are verified by experiment.
Epothilone D Improves Microtubule Density, Axonal Integrity, and Cognition in a Transgenic Mouse Model of Tauopathy

Neurons in the brains of those with Alzheimer's disease (AD) and many frontotemporal dementias (FTDs) contain neurofibrillary tangles comprised of hyperphosphorylated tau protein. Tau normally stabilizes microtubules (MTs), and tau misfolding could lead to a loss of this function with consequent MT destabilization and neuronal dysfunction. Accordingly, a possible therapeutic strategy for AD and related “tauopathies” is treatment with a MT-stabilizing anti-cancer drug such as paclitaxel. However, paclitaxel and related taxanes have poor blood–brain barrier permeability and thus are unsuitable for diseases of the brain. We demonstrate here that the MT-stabilizing agent, epothilone D (EpoD), is brain-penetrant and we subsequently evaluated whether EpoD can compensate for tau loss-of-function in PS19 tau transgenic mice that develop forebrain tau inclusions, axonal degeneration and MT deficits. Treatment of 3-month-old male PS19 mice with low doses of EpoD once weekly for a 3 month period significantly improved CNS MT density and axonal integrity without inducing notable side-effects. Moreover, EpoD treatment reduced cognitive deficits that were observed in the PS19 mice. These results suggest that certain brain-penetrant MT-stabilizing agents might provide a viable therapeutic strategy for the treatment of AD and FTDs.
Gastric microbiota and carcinogenesis: the role of non-Helicobacter pylori bacteria - A systematic review.

BACKGROUND AND AIM Helicobacter pylori is the strongest risk factor for gastric cancer. However, recent advances in DNA sequencing technology have revealed a complex microbial community in the stomach that could also contribute to the development of gastric cancer. The aim of this study was to present recent scientific evidence regarding the role of non-Helicobacter pylori bacteria in gastric carcinogenesis. METHODS A systematic review of original articles published in PubMed in the last ten years related to gastric microbiota and gastric cancer in humans was performed. RESULTS Thirteen original articles were included. The constitution of gastric microbiota appears to be significantly affected by gastric cancer and premalignant lesions. In fact, differences in gastric microbiota have been documented, depending on Helicobacter pylori status and gastric conditions, such as non-atrophic gastritis, intestinal metaplasia and cancer. Gastric carcinogenesis can be associated with an increase in many bacteria (such as Lactobacillus coleohominis, Klebsiella pneumoniae or Acinetobacter baumannii) as well as decrease in others (such as Porphyromonas spp, Neisseria spp, Prevotella pallens or Streptococcus sinensis). However, there is no conclusive data that confirms if these changes in microbiota are a cause or consequence of the process of carcinogenesis. CONCLUSIONS Even though there is limited evidence in humans, microbiota differences between normal individuals, pre-malignant lesions and gastric cancer could suggest a progressive shift in the constitution of gastric microbiota in carcinogenesis, possibly resulting from a complex cross-talk between gastric microbiota and Helicobacter pylori. However, further studies are needed to elucidate the specific role (if any) of different microorganisms.
Five-minute parameter of thromboelastometry is sufficient to detect thrombocytopenia and hypofibrinogenaemia in patients undergoing liver transplantation.

BACKGROUND Early detection of coagulopathy is important to prevent bleeding during liver transplantation (LT). Rotation thromboelastometry (ROTEM(®)) provides the earliest parameter of clot amplitudes at 5 min (A5). We evaluated whether A5 correlates with platelet count (PLT) and fibrinogen concentration (Fib) and can predict thrombocytopenia and hypofibrinogenaemia in hypocoagulable patients undergoing living-donor LT (LDLT). METHODS A total of 3446 retrospective ROTEM(®) measurements, including 1139 EXTEM, 1182 INTEM, and 1125 FIBTEM, with simultaneously measured PLT and Fib, were analysed during LDLT in 239 patients. The correlations between A5 and maximum clot firmness (MCF) index, PLT, and Fib were calculated. Receiver operating characteristic analysis with area under the curve (AUC) was used to assess A5 thresholds predictive of PLT and Fib. RESULTS The median PLT was 47 000 mm(-3) and the median Fib was 100 mg dl(-1) during LDLT. The A5 parameters of EXTEM (A5EXTEM) and INTEM (A5INTEM) were highly correlated with MCF (r=0.96 and r=0.95, respectively), PLT (r=0.76 and r=0.77, respectively), and Fib (r=0.63 and r=0.64, respectively). A5 of FIBTEM (A5FIBTEM) was also correlated with MCF (r=0.91) and Fib (r=0.75). A5EXTEM thresholds of 15 and 19 mm predicted PLT<30 000 mm(-3) (AUC=0.90) and <50 000 mm(-3) (AUC=0.87), respectively, whereas A5FIBTEM 4 mm predicted Fib<100 mg dl(-1) (AUC=0.86). Biases from A5EXTEM and A5FIBTEM to their MCFs were 16.4 and 1.3 mm, respectively. CONCLUSIONS A5 as an early variable of clot firmness is effective in detecting critically low PLT and Fib. A5 can therefore be a reliable fast index guiding transfusion therapy in hypocoagulable patients undergoing LDLT.
Detection of tropical deep convective clouds from AMSU-B water vapor channels measurements

[1] Methods to detect tropical deep convective clouds and convective overshooting from measurements at the three water vapor channels (183.3 ± 1, 183.3 ± 3, and 183.3 ± 7 GHz) of the Advanced Microwave Sounding Unit-B (AMSU-B) are presented. Thresholds for the brightness temperature differences between the three channels are suggested as criterion to detect deep convective clouds, and an order relation between the differences is used to detect convective overshooting. The procedure is based on an investigation of the influence of deep convective cloud systems on the microwave brightness temperatures at frequencies from 89 to 220 GHz using simultaneous aircraft microwave and radar measurements over two tropical deep convective cloud systems, taken during the Tropical Rainfall Measuring Mission (TRMM) Large Scale Biosphere-Atmosphere Experiment (LBA) campaign. Two other aircraft cases with deep convective cloud systems observed during the Third Convection and Moisture Experiment (CAMEX-3) are used to validate the criteria. Furthermore, a microwave radiative transfer model and simulated mature tropical squall line data derived from the Goddard Cumulus Ensemble (GCE) model are used to validate the procedures and to adapt the criteria to the varying viewing angle of AMSU-B. These methods are employed to investigate the distributions of deep convective clouds and convective overshooting in the tropics (30°S to 30°N) for the four 3-month seasons from March 2003 to February 2004 using the AMSU-B data from NOAA-15, -16, and -17. The distributions show a seasonal variability of shifting from the winter hemisphere to the summer hemisphere. The distributions of deep convective clouds follow the seasonal patterns of the surface rainfall rates. The deep convective clouds over land penetrate more frequently into the tropical tropopause layer than those over ocean. The averaged deep convective cloud fraction is about 0.3% in the tropics, and convective overshooting contributes about 26% to this.