Miracle-dz/UniFAR-FTUs huggingface dataset:
THE ESTIMATION OF ROCK MASS DEFORMATION MODULUS USING REGRESSION AND ARTIFICIAL NEURAL NETWORKS ANALYSIS

نإ م ماع ل ساسلأا ة لتآ ككفت (EM) ا خدإ لماع وه ة يئايميآويجلا لآاش ملا يف م هم ل ، ثيح إ ن لماعلا اذ ه داجيلإ ناد يملا تاصوحف نمث لا ة يلاغ و كلهتست اتقو لايوط . و مت ةيملعلا ةقرولا هذه يف باسحل نيتقيرط ريوطت (EM) . ف ىلولأا ةقيرطلا يف ل يلحت مادختساب لاا راسحن ى لع لوصحلا م ت تلاداعم سمخ ا ةيضارتف لماعب ة قلعتم (EM) ساسلأا ة لتآ ةعرس و (RMR) ، أ ثيح لماعم لضفأ دودحلا دد عتم بسانت ىطع ا طا بتر . م تو يف ىرخلأا ةقيرطلا ةدياحملا ةيعانصلا ةكبشلا مادختساب (ANN) ريوطت أ باسحل جذومن (EM) ا ادا متع يرطق فصن يفيظو ساسأ ماظن ى لع . م ت د قو ريخأ ا قيبطت تاه ي ن تقيرطلا ي ن باسح يف (EM) دسل Karun IV . امآ مت ت لا ةنراقم ميق عقوملا يف جئاتنب ةجتانلا . و ة قيرط ة قد نأ تا نراقملا ترهظأ دق ANN ليلحت ةقيرط نم لضفأ يه لاا راسحن .
Dopamine Affects Parvalbumin Expression during Cortical Development In Vitro

This study was undertaken to determine how dopamine influences cortical development. It focused on morphogenesis of GABAergic neurons that contained the calcium-binding protein parvalbumin (PV). Organotypic slices of frontoparietal cortex were taken from neonatal rats, cultured with or without dopamine, harvested daily (4–30 d), and immunostained for parvalbumin. Expression of parvalbumin occurred in the same regional and laminar sequence as in vivo. Expression in cingulate and entorhinal preceded that in lateral frontoparietal cortices. Laminar expression progressed from layer V to VI and finally II-IV. Somal labeling preceded fiber labeling by 2 d. Dopamine accelerated PV expression. In treated slices, a dense band of PV-immunoreactive neurons appeared in layer V at 7 d in vitro (DIV), and in all layers of frontoparietal cortex at 14 DIV, whereas in control slices such labeling did not appear until 14 and 21 DIV, respectively. The laminar distribution and dendritic branching of PV-immunoreactive neurons were quantified. More labeled neurons were in the superficial layers, and their dendritic arborizations were significantly increased by dopamine. Treatment with a D1 receptor agonist had little effect, whereas a D2 agonist mimicked dopamine’s effects. Likewise, the D2 but not the D1 antagonist blocked dopamine-induced changes, indicating that they were mediated primarily by D2 receptors. Parvalbumin expression was accelerated by dopaminergic reinnervation of cortical slices that were cocultured with mesencephalic slices. Coapplication of the glutamate NMDA receptor antagonist MK801 or AP5 blocked dopamine-induced increases in dendritic branching, suggesting that changes were mediated partly by interaction with glutamate to alter cortical excitability.
ASCA PV observations of the Seyfert 1 galaxy MCG – 6 – 30 – 15: rapid variability of the warm absorber

We present a detailed re-analysis of the two {\it ASCA} Performance Verification observations of the nearby Seyfert 1 galaxy MCG-6-30-15. Confirming the results of Fabian et al. (1994), we find definite evidence for the {\sc O\,vii} and {\sc O\,viii} K-shell absorption edges of the warm absorber and a doubling of the warm absorber column density within the 3 weeks separating the two observations. No intra-day {\it flux-correlated} variability of the warm absorber is found. However, we report the discovery of an `event' in which the warm absorber parameters temporarily change for \sim10\,000\thinspace s before returning to their original values. Possible interpretations are discussed but a contradiction remains: the constancy of the ionization state of the warm absorber argues that it lies at large distances from the central source whereas the short term change in column density argues for small distances. Fluorescent iron emission is examined. As found by Fabian et al. (1994), the iron line is broad and strong (equivalent width \sim300\thinspace eV). The line profile is also suggestive of it being skewed. Such a line would be expected from a relativistic accretion disk. We also find very rapid primary X-ray variability. Assuming relativistic beaming to be unimportant, the derived efficiency is comparable to the maximum obtainable from accretion onto a Schwarzschild black hole. Correlated variability outside of the energy range of {\it ASCA} might exceed this maximum, thus requiring efficient accretion onto a Kerr hole.
School Hopscotch: A Comprehensive Review of K–12 Student Mobility in the United States

This article provides an integrative review of the extant literature on K–12 student mobility in the United States. Student mobility is a widespread phenomenon with significant policy implications. Changing schools is most prevalent among minority and low-income students in urban school districts. There is an ongoing debate about whether student mobility is helpful or harmful. Earlier research compared movers with nonmovers using cross-sectional data and did not always include controls for the students’ prior achievement and demographic characteristics. Studies in the past decade compared movers with themselves over time using longitudinal data and provided more convincing estimates. Overall, switching schools is associated with a negative impact on students’ educational outcomes; however, transferring to higher quality schools may offset and outweigh the transition costs of moving. Strong causal claims are elusive due to considerable data and methodological challenges and the inability to account for the motivating reasons for changing schools.
Ultra-cool dwarfs: new discoveries, proper motions, and improved spectral typing from SDSS and 2MASS photometric colors

Aims. We try to identify ultra-cool dwarfs from the seventh Data Release of the Sloan Digital Sky Survey (SDSS DR7) with SDSS i-z and r-z colors. We also obtain proper motion data from SDSS, 2MASS, and UKIDSS and improve spectral typing from SDSS and 2MASS photometric colors. Methods. We selected ultra-cool dwarf candidates from the SDSS DR7 with new photometric selection criteria, which are based on a parameterization study of known L and T dwarfs. The objects are then cross-identified with the Two Micron All Sky Survey and the Fourth Data Release of the UKIRT Infrared Deep Sky Survey (UKIDSS DR4). We derive proper motion constraints by combining SDSS, 2MASS, and UKIDSS positional information. In this way we are able to assess, to some extent, the credence of our sample using a multi epoch approach, which complements spectroscopic confirmation. Some of the proper motions are affected by short baselines, but, as a general tool, this method offers great potential to confirm faint L dwarfs as UKIDSS coverage increases. In addition we derive updated color-spectral type relations for L and T dwarfs with SDSS and 2MASS magnitudes. Results. We present 59 new nearby M and L dwarfs selected from the imaging catalog of the SDSS DR7, including proper motions and spectral types calculated from the updated color-spectral type relations. and obtain proper motions from SDSS, 2MASS, and UKIDSS for all of our objects.
Direct Inhibitory Effects of Pioglitazone on Hepatic Fetuin-A Expression

Fetuin-A, a circulating glycoprotein synthesized in the liver, is involved in insulin resistance and type 2 diabetes. However, regulation of fetuin-A synthesis has remained obscure. We previously reported that pioglitazone treatment significantly reduced serum fetuin-A levels in patients with type 2 diabetes. To clarify whether pioglitazone can directory inhibit hepatic fetuin-A synthesis, we investigated the effects of pioglitazone on fetuin-A expression both in vitro and in vivo. Pioglitazone treatment suppressed mRNA and protein expression of fetuin-A in Fao hepatoma cells. Interestingly, rosiglitazone but not metformin, also inhibited fetuin-A expression. In addition, GW 9662, an inhibitor of peroxisome proliferator-activated receptor (PPAR) γ, reversed pioglitazone-induced suppression of fetuin-A, suggesting that thiazolidinedione derivatives may have common characteristics with regard to fetuin-A suppression, possibly through PPARγactivation. Finally, oral administration of pioglitazone to mice for 8 weeks resulted in suppression of hepatic fetuin-A mRNA. These findings suggest that pioglitazone may partially ameliorate insulin resistance through its direct inhibitory effects on fetuin-A expression in the liver.
Observer design with guaranteed RMS gain for discrete‐time LPV systems with Markovian jumps

In this paper we consider the problem of designing state observers with guaranteed power‐to‐power (RMS) gain for a class of stochastic discrete‐time linear systems that possess both measurable parameter variations and Markovian jumps in their dynamics. It is shown in the paper that an upper bound on the RMS gain of the observer can be characterized in terms of feasibility of a family of parameter‐dependent linear matrix inequalities (LMIs). Any feasible solution to these LMIs can then be used to explicitly construct a parameter‐varying jump observer that guarantees the desired performance level. This design framework is then specialized to a problem of state estimation for a linear parameter‐varying plant whose state measurements are available through a lossy Bernoulli channel. Two numerical examples illustrate the results. Copyright © 2008 John Wiley & Sons, Ltd.
On User Choice for Android Unlock Patterns

—Android Unlock Patterns are one of the most widely used graphical password schemes. However, the scheme’s security is limited by users not choosing patterns uniformly but with a speciﬁc bias. In this work we take a closer look at this bias, in particular how personal traits inﬂuence the chosen patterns. We conducted a user study with 800 participants and demonstrate that certain factors such as age, gender, and experience in IT signiﬁcantly inﬂuence the strength or length of the chosen patterns. This has implications both for how we can help users to select stronger patterns and for forensic applications.
Bayesian Nonparametric Measurement of Factor Betas and Clustering with Application to Hedge Fund Returns

We define a dynamic and self-adjusting mixture of Gaussian Graphical Models to cluster financial returns, and provide a new method for extraction of nonparametric estimates of dynamic alphas (excess return) and betas (to a choice set of explanatory factors) in a multivariate setting. This approach, as well as the outputs, has a dynamic, nonstationary and nonparametric form, which circumvents the problem of model risk and parametric assumptions that the Kalman filter and other widely used approaches rely on. The by-product of clusters, used for shrinkage and information borrowing, can be of use to determine relationships around specific events. This approach exhibits a smaller Root Mean Squared Error than traditionally used benchmarks in financial settings, which we illustrate through simulation. As an illustration, we use hedge fund index data, and find that our estimated alphas are, on average, 0.13% per month higher (1.6% per year) than alphas estimated through Ordinary Least Squares. The approach exhibits fast adaptation to abrupt changes in the parameters, as seen in our estimated alphas and betas, which exhibit high volatility, especially in periods which can be identified as times of stressful market events, a reflection of the dynamic positioning of hedge fund portfolio managers.
Action control by implementation intentions : effective cue detection and efficient response initiation

Past research has demonstrated that implementation intentions (i.e., if–then plans) facilitate goal striving by two processes: increasing the activation of the anticipated situational cue (the if–process) and automating the goal–directed response to that cue (the then–process; Gollwitzer, 1999; Webb & Sheeran, in press). Two studies investigated the implications for the course of goal striving guided by implementation intentions. When implementation intentions achieved their effects by facilitating cue identification (the if–process), alternative cues were disregarded (Study 1). On the contrary, when implementation intentions achieved their effects by the automation of the critical response (the then–process), alternative goal–directed responses were still considered (Study 2). We discuss these results with respect to the functioning of implementation intentions and the use of alternative means in planned goal pursuit.
Natural Killer Cells Promote Long-Term Hepatobiliary Inflammation in a Low-Dose Rotavirus Model of Experimental Biliary Atresia

Biliary atresia is a rapidly progressive obstructive cholangiopathy of infants. Mechanistic studies in the mouse model of Rhesus rotavirus (RRV)-induced biliary atresia have linked the importance of effector lymphocytes to the pathogenesis of extrahepatic bile duct (EHBD) injury and obstruction in experimental biliary atresia; however, studies of the progressive liver injury have been limited by early death of newborn mice. Here, we aimed to determine 1) if a lower inoculum of RRV induces obstruction of EHBDs while allowing for ongoing liver inflammation, and 2) if NK cells regulate intrahepatic injury. The administration of 0.25x106 fluorescence forming units of RRV induced an obstructive extrahepatic cholangiopathy, but allowed for restoration of the duct epithelium, increased survival, and the development of a progressive intrahepatic inflammatory injury with molecular and cellular signatures equivalent to the traditional infectious model. Investigating the mechanisms of liver injury, we found that NK cell depletion at the onset of jaundice decreased liver inflammation, suppressed the expression of fibrosis and inflammation/immunity genes, lowered plasma ALT and bilirubin and improved survival. Conclusions Lower inoculation of RRV-induced progressive liver injury and fibrosis via NK cells. These findings point to the potential use of NK cell-depleting strategies to block progression of liver disease in biliary atresia.
Who’s in charge? “Feeling stuck” vs. agency following medial prefrontal lesions: A commentary on “Revisiting the left convexity hypothesis: Changes in the mental apparatus after left dorso-medial prefrontal damage” by Salas & Yuen

In my contribution, I focus on the subjective experience and feelings that accompany dysexecutive cognitive impairment following left dorsomedial lesion, as described in this paper. This experience is compared to the experiences of other patients with left medial prefrontal lesions. Specifically, through a comparison to a patient whose dorsomedial prefrontal lesion extended also to a ventral area (ventromedial PFC), I suggest how a “secondary process mind” and a “primary process mind” interpret a similar “neurocognitive” state, in different ways. Finally, I suggest a possible primary cause for the nature of these patients’ subjective experience related to agency and MPFC.
The Myths Surrounding Pre-Exercise Carbohydrate Feeding

Background/Aims: Carbohydrate ingested 30–60 min before exercise may result in hypoglycaemia during exercise, a phenomenon often called rebound or reactive hypoglycaemia. There is considerable confusion regarding pre-exercise carbohydrate feeding with advice that ranges from ‘consume carbohydrate in the hour before exercise’ to ‘avoid carbohydrate in the 60 min prior to exercise’. Methods: We analysed the studies available in the literature to draw conclusions about the use of carbohydrate in the pre-exercise period. Results: Without performing a meta-analysis, it is clear that the risk of reduced performance is minimal as almost all studies point towards unaltered or even improved performance. This is despite the rather large metabolic changes that occur in response to pre-exercise carbohydrate feeding. Conclusion: It can be concluded that advice to avoid carbohydrate feeding in the hour before exercise is unfounded. Nevertheless athletes may develop symptoms similar to those of hypoglycaemia, even though they are rarely linked to actual low glucose concentrations. An individual approach may therefore be necessary to minimize these symptoms even though they do not appear to be related to exercise performance.
Social Harmony and Diversity: The Affordances and Constraints of Harmony as an Educational Goal

Background/Context There is a pressing need to consider how citizens should live together, especially in societies that are increasingly ethnically and politically diverse. Even though multicultural education is constructed very differently and serves very different purposes in different national contexts, relatively little attention has been paid to how education systems of countries such as China, Singapore, and the United Arab Emirates give greater emphasis to the concepts of harmony and social cohesion. Purpose/Objective This study explores some of the ways in which multicultural education is defined and conceptualized in East Asian countries. This paper draws on the case study of Singapore to interrogate the concept of harmony, investigate the implications of the state incorporating this concept as an educational goal for the public education system, and examine teachers’ understandings of multicultural education. Research Design The study adhered to the qualitative case study design. The data consisted primarily of semistructured individual interviews with 24 Singapore secondary social studies teachers, as well as relevant curricular and political documents such as the national Social Studies curriculum, political speeches, and official government publications. Guided by the literature, the interviewers asked questions to surface the participants’ understandings of the definition, purposes, and practices of multicultural education. Subsequently, the interviewers used follow-up questions to probe further and elicit additional description of how the teachers arrived at these understandings. The data analysis, shaped largely by the constant comparative method, was data-driven and inductive. Conclusions/Recommendations By illustrating some of the affordances and constraints of incorporating harmony as an educational goal, this study offers multicultural education scholars and teacher educators an opportunity to better understand some of the ways in which multicultural education is conceptualized in East Asian countries with strong Confucian traditions. The findings from this study suggest that a focus on harmony as an educational goal may help facilitate a move away from programs that emphasize the development of individual students’ social and political competencies towards programs and policies designed to promote communal trust and social cohesion. Finally, this study illustrates some of the challenges teachers face when balancing the goals of building trust and harmony within society and interrogating entrenched interests, institutional inequality, and unequal power relations.
Upregulation of the expression of Wnt5a promotes the proliferation of pancreatic cancer cells in vitro and in a nude mouse model

Wnt proteins are a group of secreted signaling proteins, which function to regulate cell fate and pattern formation during embryogenesis. Altered expression of Wnt5a has been implicated in human carcinogenesis and tumor progression. A previous study identified that Wnt5a is overexpressed in human pancreatic cancer tissues, and that upregulated expression of Wnt5a promotes tumor cell migration and invasion. The present study investigated the role of Wnt5a in pancreatic cancer cell proliferation in vitro and in an orthotopic nude mouse model. Wnt5a cDNA or small interfering RNA were stably transfected into pancreatic cancer cells to assess cell proliferation-associated behaviors, including cell viability, colony formation and apoptosis in vitro, as well as tumor cell growth in an orthotopic nude mouse model. Western blot analysis was used to analyze the expression of Wnt signaling molecules. The data showed that upregulation of the expression of Wnt5a significantly promoted proliferation of the human pancreatic cells, but inhibited tumor cell apoptosis in vitro and promoted tumor growth in an orthotopic nude mouse model. By contrast, knockdown of the expression of Wnt5a inhibited cell growth and promoted apoptosis of the pancreatic cancer cells. The data also revealed that β-catenin mediated the effects of Wnt5a on the regulation of pancreatic cancer cell apoptosis in vitro. These results suggested that Wnt5a is involved in the modulation of pancreatic cancer cell proliferation, and that Wnt5a may be a potential target for pancreatic cancer therapy.
TMPRSS2- Driven ERG Expression In Vivo Increases Self-Renewal and Maintains Expression in a Castration Resistant Subpopulation

Genomic rearrangements commonly occur in many types of cancers and often initiate or alter the progression of disease. Here we describe an in vivo mouse model that recapitulates the most frequent rearrangement in prostate cancer, the fusion of the promoter region of TMPRSS2 with the coding region of the transcription factor, ERG. A recombinant bacterial artificial chromosome including an extended TMPRSS2 promoter driving genomic ERG was constructed and used for transgenesis in mice. TMPRSS2-ERG expression was evaluated in tissue sections and FACS-fractionated prostate cell populations. In addition to the anticipated expression in luminal cells, TMPRSS2-ERG was similarly expressed in the Sca-1hi/EpCAM+ basal/progenitor fraction, where expanded numbers of clonogenic self-renewing progenitors were found, as assayed by in vitro sphere formation. These clonogenic cells increased intrinsic self renewal in subsequent generations. In addition, ERG dependent self-renewal and invasion in vitro was demonstrated in prostate cell lines derived from the model. Clinical studies have suggested that the TMPRSS2-ERG translocation occurs early in prostate cancer development. In the model described here, the presence of the TMPRSS2-ERG fusion alone was not transforming but synergized with heterozygous Pten deletion to promote PIN. Taken together, these data suggest that one function of TMPRSS2-ERG is the expansion of self-renewing cells, which may serve as targets for subsequent mutations. Primary prostate epithelial cells demonstrated increased post transcriptional turnover of ERG compared to the TMPRSS2-ERG positive VCaP cell line, originally isolated from a prostate cancer metastasis. Finally, we determined that TMPRSS2-ERG expression occurred in both castration-sensitive and resistant prostate epithelial subpopulations, suggesting the existence of androgen-independent mechanisms of TMPRSS2 expression in prostate epithelium.
Identification and Characterization of Cholest-4-en-3-one, Oxime (TRO19622), a Novel Drug Candidate for Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by progressive death of cortical and spinal motor neurons, for which there is no effective treatment. Using a cell-based assay for compounds capable of preventing motor neuron cell death in vitro, a collection of approximately 40,000 low-molecular-weight compounds was screened to identify potential small-molecule therapeutics. We report the identification of cholest-4-en-3-one, oxime (TRO19622) as a potential drug candidate for the treatment of ALS. In vitro, TRO19622 promoted motor neuron survival in the absence of trophic support in a dose-dependent manner. In vivo, TRO19622 rescued motor neurons from axotomy-induced cell death in neonatal rats and promoted nerve regeneration following sciatic nerve crush in mice. In SOD1G93A transgenic mice, a model of familial ALS, TRO19622 treatment improved motor performance, delayed the onset of the clinical disease, and extended survival. TRO19622 bound directly to two components of the mitochondrial permeability transition pore: the voltage-dependent anion channel and the translocator protein 18 kDa (or peripheral benzodiazepine receptor), suggesting a potential mechanism for its neuroprotective activity. TRO19622 may have therapeutic potential for ALS and other motor neuron and neurodegenerative diseases.