Miracle-dz/UniFAR-FTUs huggingface dataset:
Conflicting data on the prognostic significance of FLT3/TKD mutations in acute myeloid leukemia might be related to the incidence of biallelic disease.

To the editor: We read with interest the paper from Whitman and colleagues[1][1] reporting an adverse impact on disease-free survival of FLT3 tyrosine kinase domain ( FLT3 /TKD) mutations in 19 of 217 patients with normal karyotype acute myeloid leukemia (AML). This contrasts with our data where
The Second World Cancer Research Fund/American Institute for Cancer Research Expert Report. Food, Nutrition, Physical Activity, and the Prevention of Cancer: A Global Perspective

It has been estimated by various authorities that about one-third of cancers in Western high-income societies are attributable to factors relating to food, nutrition and physical activity. Identifying with confidence specific associations between dietary patterns, foods, body composition or individual nutrients is not simple because of the long latent period for cancer development, its complex pathogenesis and the challenge of characterising the multidimensional aspects of diet and activity over a lifetime. Reliable conclusions must therefore be drawn not only from randomised controlled trials but from a variety of methodological approaches, judged within a classic framework for inferring causality. Using a newly-developed method with a protocol for standardising the literature search and for analysis and display of the evidence, nine independent academic centres have conducted systematic reviews addressing the causal associations between food, nutrition and physical activity and risk of development of seventeen cancers, as well as of weight gain and obesity. A review has also examined the efficacy of such interventions in subjects with cancer. The reviews have been assessed by an independent Panel of twenty-one international experts who drew conclusions with grades of confidence in the causality of associations and made recommendations. Recommendations are given as public health goals as well as for individuals.
Safety nets and production systems: Evidence from a pseudo-panel of Ghanaian household data

Empirical research has shown that poor households involved in low-risk low-return low-input subsistence activities, once protected by a safety net, might opt for activities which, although riskier and requiring much more inputs, ultimately lead to a higher living standard. This paper expands on recent theoretical advances and applies an innovative empirical strategy to study this phenomenon. In particular we compare the dynamics of two household production systems, a low-risk system that is typical for the poor and a high-risk system with a much higher equilibrium living standard. Each system has a threshold initial living standard or setup cost which can induce a poverty trap. Presumably, both the threshold and the risk are particularly high for the high-income system, implying that households opting for this system must be sufficiently wealthy to start with and also need additional protection from a safety net. Few studies have brought this model to test, especially in Sub-Saharan Africa where widespread safety nets are rare and household panel data, if available, consist of only small samples. To test this model we find an empirical approximation of the construct of safety nets and production systems by pooling five rounds of a large-scale household survey in Ghana, covering the period 1988 to 2006. Specifically we construct a pseudo-panel based on demographic and geographical characteristics and use access to clean drinking water as a proxy for the set-up cost of production systems and access to remittances as a proxy for protection from a safety net. Findings indicate that access to clean drinking water and to remittances, particularly from overseas, are both instrumental to higher income growth. It is, however, important to note that poor households can seldom afford to have family members abroad implying that they are much less likely to receive protection from such a safety net. This highlights that the inclusive provision of basic household amenities and the inclusive access to a safety net are key elements to help the poor getting out of subsistence.
Discovery of the neutron star nature of SLX 1737-282

SLX 1737-282 is a persistent moderately bright X-ray source 1$\fdg$2 from the Galactic center. X-ray observations with the Wide Field Cameras on BeppoSAX have for the first time revealed the true nature of SLX 1737-282: a 15 min long thermonuclear flash was detected exposing the source as a neutron star in a binary system. The flash was Eddington-limited constraining the distance to between 5 and 8 kpc. We analyze BeppoSAX, ROSAT, and RXTE data on SLX 1737-282. The persistent 0.5–200 keV luminosity is close to or less than 1% of the Eddington limit which implies a rarely-seen circumstance for thermonuclear flash activity.
Antimicrobial resistance pattern of Gram-negative bacilli isolated from patients at ICUs of Army hospitals in Iran

Background and Objectives Patients at intensive-care-unit (ICU) are at risk of acquiring nosocomial infections which contributes to higher rates. Approximately 25% of all hospital infections and 90% of outbreaks occur in ICUs. Multi- resistant gram-negative rods are important pathogens in ICUs, causing high rate of mortality. The purpose of this study was to investigate the antimicrobial resistance patterns among common Gram-negative bacilli isolated from patients with nosocomial infection at Army Hospitals. Materials and Methods A total of 187 isolates of Gram-negative bacilli were isolated from 904 patients at ICUs of three Army hospitals in Iran during May 2007 to May 2008. All isolates were examined for antimicrobial resistance using disc diffusion method. Results The most frequent pathogens were E. coli (32.08%) followed by K. pneumoniae (31%), P. aeruginosa (12.8%) and Acinetobacter spp. (9.1%). High rate of resistance to third generation cephalosporines was observed among isolates of E. coli and K. pneumoniae. Production of extended spectrum beta lactamases (ESBLs) was found in 46.6% of isolates of both organisms, but in 38% of all Gram negative bacteria. Conclusion The prevalence of ESBL producing strains at three Army Hospitals is considerable (38%). However, resistance to imipenem has emerged in these hospitals. Furthermore, studies are required to clarify the situation with multi-drug resistant organisms including the Gram positive bacteria at Army hospitals.
The Impact of Latino Family Variables on the Sexual Activity of Latino Adolescents: A Mixed-Methods Study

THE IMPACT OF LATINO FAMILY VARIABLES ON THE SEXUAL ACTIVITY OF LATINO ADOLESCENTS: A MIXED-METHODS STUDY Brittany N. Barber, M.A. Marquette University, 2011 Researchers‟ examination of Latino adolescents‟ cultural values and sexual activity has yielded questions regarding the culturaland gender-specific attitudes and practices in this area (Deardorff, Tschann, & Flores, 2008). Cultural values include family-related variables such as different aspects of familism, parent-adolescent communication, and parental monitoring, which have been found to decrease adolescents‟ engagement in other negative activities such as aggressive behavior, (Dishion & McMahon, 1998), substance use (Estrada, Rabow, & Watts, 1982), and juvenile delinquency (Clark & Shields, 1997). Research investigating these risk behaviors has often implicated Latino adolescents‟ level of assimilation to White, mainstream society as a potential risk factor for higher engagement in negative behaviors, emphasizing the importance of better understanding the cultural context in which Latino youth live and how it may impact their risky behavior. This dissertation study, therefore, examined the relationship between five Latino family variables (i.e., attitudinal familism, behavioral familism, structural familism, parent-adolescent communication, and parental monitoring), assimilation to White culture, and the sexual activity beliefs and behaviors of Latino adolescents. A mixedmethods project explored and tested the relationships between these variables. Four gender-specific focus groups were conducted with adolescents; data were analyzed using Grounded Theory methodology (Strauss & Corbin, 1990). Also, 410 Latino youth completed quantitative surveys about their family-related behaviors, attitudes, and sexual activity. Relationships among these variables were tested using correlations and regressions. Primary findings from the qualitative study indicated that gender differences in Latino families‟ communication about sex and monitoring behaviors impacts Latina girls‟ and Latino boys‟ sexual activity beliefs. Differences observed with regard to gender were such that Latina girls‟ felt sexual activity was not appropriate for teenagers, whereas the boys felt that it was acceptable for teenagers to engage in sexual activity as long as they used a contraceptive method. Quantitative results indicated parental monitoring and some aspects of familism were found to be related to a decreased likelihood of engaging in sexual activity for the girls and boys. High assimilation to White, mainstream culture was not found to impact sexual activity beliefs or behaviors in the current study. Running head: LATINO FAMILY VARIABLES AND SEXUAL ACTIVITY i
Multiagent Only Knowing in Dynamic Systems

The idea of "only knowing" a collection of sentences, as proposed by Levesque, has been previously shown to be very useful in characterizing knowledge-based agents: in terms of a specification, a precise and perspicuous account of the beliefs and non-beliefs is obtained in a monotonic setting. Levesque's logic is based on a first-order modal language with quantifying-in, thus allowing for de re versus de dicto distinctions, among other things. However, the logic and its recent dynamic extension only deal with the case of a single agent. In this work, we propose a first-order multiagent framework with knowledge, actions, sensing and only knowing, that is shown to inherit all the features of the single agent version. Most significantly, we prove reduction theorems by means of which reasoning about knowledge and actions in the framework simplifies to non-epistemic, non-dynamic reasoning about the initial situation.
Noise-Assisted Instantaneous Coherence Analysis of Brain Connectivity

Characterizing brain connectivity between neural signals is key to understanding brain function. Current measures such as coherence heavily rely on Fourier or wavelet transform, which inevitably assume the signal stationarity and place severe limits on its time-frequency resolution. Here we addressed these issues by introducing a noise-assisted instantaneous coherence (NAIC) measure based on multivariate mode empirical decomposition (MEMD) coupled with Hilbert transform to achieve high-resolution time frequency representation of neural coherence. In our method, fully data-driven MEMD, together with Hilbert transform, is first employed to provide time-frequency power spectra for neural data. Such power spectra are typically sparse and of high resolution, that is, there usually exist many zero values, which result in numerical problems for directly computing coherence. Hence, we propose to add random noise onto the spectra, making coherence calculation feasible. Furthermore, a statistical randomization procedure is designed to cancel out the effect of the added noise. Computer simulations are first performed to verify the effectiveness of NAIC. Local field potentials collected from visual cortex of macaque monkey while performing a generalized flash suppression task are then used to demonstrate the usefulness of our NAIC method to provide highresolution time-frequency coherence measure for connectivity analysis of neural data.
Prognostic role of KRAS and BRAF in stage II and III resected colon cancer: results of the translational study on the PETACC-3, EORTC 40993, SAKK 60-00 trial.

PURPOSE Mutations within the KRAS proto-oncogene have predictive value but are of uncertain prognostic value in the treatment of advanced colorectal cancer. We took advantage of PETACC-3, an adjuvant trial with 3,278 patients with stage II to III colon cancer, to evaluate the prognostic value of KRAS and BRAF tumor mutation status in this setting. PATIENTS AND METHODS Formalin-fixed paraffin-embedded tissue blocks (n = 1,564) were prospectively collected and DNA was extracted from tissue sections from 1,404 cases. Planned analysis of KRAS exon 2 and BRAF exon 15 mutations was performed by allele-specific real-time polymerase chain reaction. Survival analyses were based on univariate and multivariate proportional hazard regression models. RESULTS KRAS and BRAF tumor mutation rates were 37.0% and 7.9%, respectively, and were not significantly different according to tumor stage. In a multivariate analysis containing stage, tumor site, nodal status, sex, age, grade, and microsatellite instability (MSI) status, KRAS mutation was associated with grade (P = .0016), while BRAF mutation was significantly associated with female sex (P = .017), and highly significantly associated with right-sided tumors, older age, high grade, and MSI-high tumors (all P < 10(-4)). In univariate and multivariate analysis, KRAS mutations did not have a major prognostic value regarding relapse-free survival (RFS) or overall survival (OS). BRAF mutation was not prognostic for RFS, but was for OS, particularly in patients with MSI-low (MSI-L) and stable (MSI-S) tumors (hazard ratio, 2.2; 95% CI, 1.4 to 3.4; P = .0003). CONCLUSION In stage II-III colon cancer, the KRAS mutation status does not have major prognostic value. BRAF is prognostic for OS in MS-L/S tumors.
Ambient Awareness and Knowledge Acquisition: Using Social Media to Learn "Who Knows What" and "Who Knows Whom"

The argument proffered in this paper is that use of enterprise social networking technologies can increase the accuracy of people's metaknowledge (knowledge of "who knows what" and "who knows whom") at work. The results of a quasi-natural field experiment in which only one of two matched-sample groups within a large financial services firm was given access to the enterprise social networking technology for six months revealed that by making people's communications with specific partners visible to others in the organization, the technology enabled observers to become aware of the communications occurring amongst their coworkers and to make inferences about what and whom those coworkers knew based on the contents of the messages they sent and to whom they were sent. Consequently only individuals in the group that used the social networking technology for six months improved the accuracy of their metaknowledge (a 31% improvement in knowledge of who knows what and an 88% improvement in knowledge of who knows whom). There were no improvements in the other group over the same time period. Based on these findings, how technologically enabled "ambient awareness"--awareness of ambient communications occurring amongst others in the organization--can be an important antecedent for knowledge acquisition is discussed.
REFINED ANALYSIS OF INTERPLANETARY H-LYALPHA SPECTRA OBTAINED WITH THE HUBBLE-SPACE TELESCOPE GHRS SPECTROMETER

Here we present a new synoptic analysis of 5 HST- GHRS interplanetary H-Ly spectra obtained at different lines of sight from different positions of the earth in its orbit. The spectral analysis aimed at the derivation of actual interstellar gas parameters is carried out on the basis of a newly developed Ly radiation transport code taking into account the effects of angle-dependentpartialfrequencyredistribution,selfabsorption by the interplanetary hydrogen, and the actual spectral prole of the solar Ly emission line. As is shown the ve different spectra, registered over a total time period of 18 months, when analyzed separately will lead to slightly different LISM param- eters, however, if analyzed synoptically can also be reasonably wellexplainedbyonecommonsetofLISMparameters.Hereby the t achieved with the most conventional LISM parameter set (T = 8000 K ;v=2 6km/s) can be improved by red-shifting the upwind spectra by -5 km/s. This shift, as we are going to argue, is best explained by a 30 o -tilt of the symmetry axis of the heliospheric interface with respect to the LISM helium inflow direction, which could easily be established by LISM magnetic elds of a few Gauss tilted with respect to the helium inflow direction. Enhanced values for the solar Ly radiation pressure ( =1 :8) would reduce the needed redshift to less than 2.5 km/s (tilt angles much lower than 30 o ).
Learning Styles of Undergraduate Musical Students Attending Music College in Thailand

Some previous studies postulate that every individual has a different learning style. Students have preferences for the ways in which they receive information. One of the most challenges that music educator in Thailand face today is improving the level of music student satisfaction with the curriculum and learning environment. To determine whether a particular teaching method might enhance student satisfaction with the learning process, a learning preferences survey linked to sensory modalities was given to music students of Undergraduate Studies at College of Music Mahidol University, Thailand. The survey called VARK (an acronym for Visual, Aural, Read-Write, and Kinesthetic) was applied in order to identify student's preferences for particular modes of information presentation. The purpose of this descriptive study was thus to determine the learning style and measure the distribution of learning preference mean scores of the music students and note any significant differences among classes and gender determined using 348 participants from the Mahidol University College of Music, Thailand, in 2008-2009. According to the VARK questionnaire, students were divided into five groups (visual, auditory, read-write, kinesthetic, and multimodal learners). The unimodality preference was 33.9 % and multimodality was 66.1 %. Among the students who preferred one mode of information presentation, 15.3 % were kinesthetic, 62.7 % were auditory, 10.2 % were visual, and 11.9 % were read-write learners, respectively. Some students preferred multiple modes: bimodal (26.4 %), trimodal (27.3 %), and quadmodal (12.4 %), respectively. Music students prefer aural learning at a higher percentage than other modes. Inter-class differences varied while gender differences were not significant. Introducing the VARK survey can provide a vehicle for self-knowledge and to explore opportunities for making the music educational experience both more productive and enjoyable for students and faculty members. Knowing the music students preferred learning modes can: (1) help provide instruction tailored to the student's individual preferences, (2) overcome the predisposition to treat all music students in a similar way, (3) motivate teachers to move from their preferred mode(s) to using others, and (4) develop appropriate learning approaches and explore opportunities so that music educators will be able to make the educational experience more productive.
Interactive effects of flow speed and particle concentration on growth rates of an active suspension feeder

Suspension‐feeding organisms dominate subtidal habitats in the Gulf of Maine (GOM) at depths of 25–40 m. Parasmittina jeffreysi is an encrusting cheilostome bryozoan found in this zone throughout the GOM. Regional variation between coastal and offshore locations in both flow speed and particle concentration makes the GOM an ideal location to study the effect of these factors on the growth of P. jeffreysi. Particle flux measurements at two offshore and two coastal sites indicated that flow speeds were >3‐fold greater offshore than at coastal sites. Chlorophyll a concentrations and particulate quantity and quality were greater at offshore sites, but sedimentation rates were greater in the coastal region. The growth rate of P. jeffreysi was measured at each of the sites using unob‐structed colonies free from spatial competition and colonies that remained within their natural community.
Emission of Positron Annihilation Line Radiation by Clusters of Galaxies

Clusters of galaxies are enriched with positrons from jets of active galactic nuclei (AGNs) or from the interaction of cosmic rays with the intracluster gas. We follow the cooling of these positrons and show that their eventual annihilation with cluster electrons yields a narrow annihilation line. Unlike annihilation in the interstellar medium of galaxies, the line produced in clusters is not smeared by three-photon decay of positronium because positronium formation is suppressed at the high (≳1 keV) temperature of the cluster electrons. We show that if AGN jets are composed of e+e- pairs, then the annihilation line from rich clusters within a distance of 100 Mpc might be detectable with future space missions, such as the International Gamma-Ray Astrophysical Laboratory or the Energetic X-Ray Imaging Survey Telescope.
From Bogey Mountains to Funny Houses

THIS STUDY ANSWERS the following questions: ‘In what kinds of environments do preschool children want to play? ’ and ‘In what kinds of environments do boys and girls want to play? ’ Methodologically, the study draws on grounded theory, with data collected among Finnish preschoolers through 15 creation sessions with 49 children from six to seven years of age. Children prefer emotional play worlds, where excitement and amusement can be experienced and where collaborative activities and nature are afforded. Girls created scary and happy play worlds and boys created worlds of aggression and care. Emotional worlds indicate: (1) rich and varied emotions; (2) a desire for physical activity and nature; and (3) common and divergent emotional worlds of the genders. The outcomes have been utilised in designing pilot playful learning environments (PLE) and they will be useful in developing PLEs and play to meet the challenges of education.
The Relationship Between User Participation and User Satisfaction: An Investigation of Four Contingency Factors

User participation has been widely touted by the MIS community as a means to improve user satisfaction with systems development. This claim, however, has not been consistently substantiated in the empirical literature. In seeking to explain such equivocal results, the effects of four contingency factors - task complexity, system complexity, user influence, and user-developer communication - on the relationship between user participation and user satisfaction were investigated. As suggested in the literature, this research tests hypotheses that these specific contingency factors should aid in identifying situations where user participation would have a strong relationship with satisfaction.Analysis of 151 independent system development projects in eight different organizations indicated that user participation has a direct relationship with user satisfaction. In addition, the four contingency factors were found to play key roles on this relationship. Task complexity and system complexity proved to be pure motivators. That is, the strength of the participation-satisfaction relationship depended on the level of these factors. In projects where there was a high level of task complexity or system complexity, the relationship between user participation and user satisfaction was signifiantly stronger than in projects where task complexity or system complexity was low. User influence and user-developer communication were shown to be independent predictors of user satisfaction. That is, user influence or user-developer communication was positively related to user satisfaction regardless of the level of participation.The results help explain the relationship between user participation and user satisfaction by suggesting the nature of the relationship under different sets of conditions. The implications are relevant to system developers and to academicians seeking to explain how, when, why, and where user participation is needed.