Miracle-dz/UniFAR-FTUs huggingface dataset:
Does Long-Term Continuous Transcranial Doppler Monitoring Require a Pause for Safer Use?

Background: Transcranial Doppler sonography (TCD) has been used widely for long-term monitoring of cerebral blood flow without adverse reports. However, attention has not been adequately paid to the fact that an increase in the time period of TCD insonation causes brain temperature to rise due to ultrasound absorption by tissue and the skull. We measured the actual temperature rise in local brain tissue induced by TCD insonation over a long time period duringin vivo animal experiments in order to verify whether or not a pause is required in long-term, continuous TCD monitoring. Methods: We inserted thermocouples into the skull-brain interface (SBI) of 15 New Zealand White rabbits (10: TCD application group; 5: control group, TCD non-application group). The TCD probe was placed on the parietal bone, and changes in SBI temperature (SBIT) were measured for 90 min. TCD was set at maximum output level (0.2 W, 2 MHz). Results: SBIT in the TCD group increased rapidly to 3.47°C within 25 min and then reached a plateau. The maximum time for safe continuous TCD application is estimated to be 33 min. Conclusions: Even though there are large differences in factors, such as brain volume and environmental conditions, between rabbits and humans, there is less difference in their cerebral blood flow per brain weight, which is the parameter that is mainly associated with heat reduction. Accordingly, the findings of the present experiment suggest that long-term TCD monitoring in clinical use should include a pause after every 30 min of insonation to avoid thermal damage to the brain surface.
The trophic vacuum and the evolution of complex life cycles in trophically transmitted helminths

Parasitic worms (helminths) frequently have complex life cycles in which they are transmitted trophically between two or more successive hosts. Sexual reproduction often takes place in high trophic-level (TL) vertebrates, where parasites can grow to large sizes with high fecundity. Direct infection of high TL hosts, while advantageous, may be unachievable for parasites constrained to transmit trophically, because helminth propagules are unlikely to be ingested by large predators. Lack of niche overlap between propagule and definitive host (the trophic transmission vacuum) may explain the origin and/or maintenance of intermediate hosts, which overcome this transmission barrier. We show that nematodes infecting high TL definitive hosts tend to have more successive hosts in their life cycles. This relationship was modest, though, driven mainly by the minimum TL of hosts, suggesting that the shortest trophic chains leading to a host define the boundaries of the transmission vacuum. We also show that alternative modes of transmission, like host penetration, allow nematodes to reach high TLs without intermediate hosts. We suggest that widespread omnivory as well as parasite adaptations to increase transmission probably reduce, but do not eliminate, the barriers to the transmission of helminths through the food web.
Isolongifolenone: A Novel Sesquiterpene Repellent of Ticks and Mosquitoes

ABSTRACT A naturally occurring sesquiterpene, isolongifolenone, derivatives of which have been used extensively as ingredients in the cosmetics industry, was discovered to effectively repel blood-feeding arthropods that are important disease vectors. We show that (—)-isolongifolenone deters the biting of the mosquitoes, Aedes aegypti (L.) and Anopheles stephensi Liston, more effectively than the widely used synthetic chemical repellent, N,N-diethyl-3-methyl benzamide (DEET), in laboratory bioassays. The compound also repelled blacklegged ticks, Ixodes scapularis Say, and lone star ticks, Amblyomma americanum (L.), as effectively as DEET. Isolongifolenone is easily synthesized from inexpensive turpentine oil feedstock. We are therefore confident that the compound has significant potential as an inexpensive and safe repellent for protection of large human populations against blood-feeding arthropods.
Design and implementation of a shared memory switch fabric

Broadband networks satisfy the need to carry integrated traffic involving different types of information such as voice, video and data. Furthermore different services with multiple requirements need specific capabilities to be provided and guaranteed by broadband networks. The architecture of next generation networks has an important effect on changing the broadband networks and providing these capabilities. On the other hand, the architecture of broad band networks is highly affected by high speed switches. In fact, high speed switches are the target technology to achieve the required capabilities. The performance demands and changes in IC and VLSI technology have led to emergence of different types of switch architectures. This paper, proposes the architectural details of a scalable, high speed shared memory switch fabric which is operating at 20Gbps. The presented architecture is implemented using FPGA technology based on Xilinx's Virtex 4 family. The design presents a scalable architecture by implementing dynamic address allocation and efficient internal timing management. In our proposed architecture, we also consider some of VLSI design issues to make it more appropriate for further chip designs.
Variable Sampling Interval Cumulative Count of Conforming Chart with Runs Rules

The cumulative count of conforming (CCC) chart is effective in detecting very low fraction of nonconforming items for high yield manufacturing processes. In this study, a combination of runs rules and variable sampling interval feature is proposed to a lower sided CCC chart by inspecting the items one by one. The performance measures of the control chart are derived by using the Markov chain approach. The numerical comparisons show that the performance of the CCC chart can be improved by adding the runs rules and varying the sampling interval.
Transcription Factor CREB3L1 Regulates Endoplasmic Reticulum Stress Response Genes in the Osmotically Challenged Rat Hypothalamus

Arginine vasopressin (AVP) is synthesised in magnocellular neurons (MCNs) of supraoptic nucleus (SON) and paraventricular nucleus (PVN) of the hypothalamus. In response to the hyperosmotic stressors of dehydration (complete fluid deprivation, DH) or salt loading (drinking 2% salt solution, SL), AVP synthesis increases in MCNs, which over-burdens the protein folding machinery in the endoplasmic reticulum (ER). ER stress and the unfolded protein response (UPR) are signaling pathways that improve ER function in response to the accumulation of misfold/unfold protein. We asked whether an ER stress response was activated in the SON and PVN of DH and SL rats. We observed increased mRNA expression for the immunoglobulin heavy chain binding protein (BiP), activating transcription factor 4 (Atf4), C/EBP-homologous protein (Chop), and cAMP responsive element binding protein 3 like 1 (Creb3l1) in both SON and PVN of DH and SL rats. Although we found no changes in the splicing pattern of X box-binding protein 1 (Xbp1), an increase in the level of the unspliced form of Xbp1 (Xbp1U) was observed in DH and SL rats. CREB3L1, a novel ER stress inducer, has been shown to be activated by ER stress to regulate the expression of target genes. We have previously shown that CREB3L1 is a transcriptional regulator of the AVP gene; however, a role for CREB3L1 in the response to ER stress has yet to be investigated in MCNs. Here, we used lentiviral vectors to introduce a dominant negative form of CREB3L1 (CREB3L1DN) in the rat SON. Expression of CREB3L1DN in the SON decreased Chop and Xbp1U mRNA levels, but not BiP and Atf4 transcript expression. CREB3L1 is thus implicated as a transcriptional mediator of the ER stress response in the osmotically stimulated SON.
An Anatomical Study of the Gracilis Muscle and Its Application in Groin Wounds

The management of groin wounds is a common and challenging problem encountered in surgical practice. The purpose of this study is to examine the anatomic basis of the gracilis muscle with relation to this problem. Twelve cadaveric lower limbs were studied to examine both the extramuscular and intramuscular vasculature of the gracilis muscle. These underwent dissection and in 3 cases radiologic examination. The mean entry point of the dominant arterial pedicle was 9.4 cm, with mean length and width of the muscle recorded as 38.4 cm and 6.2 cm, respectively. Each gracilis muscle was then mobilized between the adductor longus and adductor magnus muscles on its dominant pedicle and transposed into the femoral triangle. In each case, the gracilis muscle mobilized easily on its dominant pedicle to adequately cover the groin. The gracilis muscle is a reliable muscle flap with a consistent blood supply, which can be transposed easily into the groin, based on its dominant pedicle, and offers adequate coverage of the femoral vessels.
Chronic obstructive pulmonary disease and asthma‐associated Proteobacteria, but not commensal Prevotella spp., promote Toll‐like receptor 2‐independent lung inflammation and pathology

Recent studies of healthy human airways have revealed colonization by a distinct commensal bacterial microbiota containing Gram‐negative Prevotella spp. However, the immunological properties of these bacteria in the respiratory system remain unknown. Here we compare the innate respiratory immune response to three Gram‐negative commensal Prevotella strains (Prevotella melaninogenica, Prevotella nanceiensis and Prevotella salivae) and three Gram‐negative pathogenic Proteobacteria known to colonize lungs of patients with chronic obstructive pulmonary disease (COPD) and asthma (Haemophilus influenzae B, non‐typeable Haemophilus influenzae and Moraxella catarrhalis). The commensal Prevotella spp. and pathogenic Proteobacteria were found to exhibit intrinsic differences in innate inflammatory capacities on murine lung cells in vitro. In vivo in mice, non‐typeable H. influenzae induced severe Toll‐like receptor 2 (TLR2)‐independent COPD‐like inflammation characterized by predominant airway neutrophilia, expression of a neutrophilic cytokine/chemokine profile in lung tissue, and lung immunopathology. In comparison, P. nanceiensis induced a diminished neutrophilic airway inflammation and no detectable lung pathology. Interestingly, the inflammatory airway response to the Gram‐negative bacteria P. nanceiensis was completely TLR2‐dependent. These findings demonstrate weak inflammatory properties of Gram‐negative airway commensal Prevotella spp. that may make colonization by these bacteria tolerable by the respiratory immune system.
Source monitoring in children with and without fetal alcohol spectrum disorders.

OBJECTIVES Deficits in memory are well-documented in children with fetal alcohol spectrum disorders (FASD); however, one aspect of memory not yet studied in children with FASD is source monitoring. This study examined overall source monitoring ability and performance profiles of children with FASD compared to controls. METHOD Participants included 19 children with FASD and 38 typically developing children (aged 6-12 years). Children were presented with auditory word lists and were required to recall the source of words for reality, external, and internal source monitoring tasks. RESULTS Children with FASD showed poorer performance than controls across all three conditions in both recognition memory and memory for source. However, both groups exhibited a comparable pattern of performance across conditions. Specifically, performance was lowest on the internal task and highest on the reality task. CONCLUSIONS Information about source monitoring deficits further delineates the intricacies of memory deficits in FASD, and has implications for both assessment and intervention.
Platelet Microparticles Enhance the Vasoregenerative Potential of Angiogenic Early Outgrowth Cells After Vascular Injury

Background— Angiogenic early outgrowth cells (EOCs) have been reported to contribute to endothelial regeneration and to limit neointima formation after vascular injury. Vascular pathologies comprise platelet activation and concomitant generation of platelet microparticles (PMPs). We hypothesized that PMPs may interact with EOCs in the context of vascular injury and modulate their regenerative potential. Methods and Results— Using flow cytometry, confocal microscopy, and scanning electron microscopy, we demonstrated the binding of thrombin/collagen-induced PMPs to EOCs with subsequent membrane assimilation and incorporation. This interaction promoted phenotypic alterations of EOCs with increased expression of endothelial cell markers and transfer of the chemokine receptor CXCR4 to EOCs with enhanced responsiveness to its ligand CXCL12/SDF-1&agr;. In addition, PMPs augmented the adhesion of EOCs to extracellular matrix components and to the injured vessel wall and accelerated cytoskeletal reorganization and migration of EOCs. PMPs induced changes in the EOC secretome toward a more proangiogenic profile and amplified the EOC-mediated induction of proliferation, migration, and capillary tube formation by mature endothelial cells. Compared with untreated EOCs, the injection of PMP-treated EOCs resulted in accelerated reendothelialization after arterial denudation injury in athymic nude mice, whereas the EOC-mediated reduction of neointima formation remained unchanged. Conclusions— Our data provide evidence that PMPs can boost the potential of EOCs to restore endothelial integrity after vascular injury. Major mechanisms involve the enhancement of EOC recruitment, migration, differentiation, and release of proangiogenic factors.
MRI findings in painful metal-on-metal hip arthroplasty.

OBJECTIVE The objective of our study was to compare the frequency of osseous and soft-tissue abnormalities in patients presenting with hip pain after resurfacing arthroplasty and after total hip arthroplasty (THA), correlate the MRI findings with histologic results, and determine which MRI findings are predictive of aseptic lymphocytic vasculitis-associated lesions. MATERIALS AND METHODS The MRI examinations of patients with metal-on-metal hip prostheses placed at resurfacing arthroplasty (n=31) or THA (n=29) were reviewed for osteolysis, synovitis, extracapsular disease, synovial pattern, and mode of decompression into adjacent bursae. Regional muscles and tendons were assessed for tendinosis, tear, atrophy, and edema. Histologic and operative findings were reviewed in 19 patients (20 hips) who underwent revision surgery. Chi-square tests were performed to detect differences between the resurfacing arthroplasty and THA groups. The Wilcoxon rank sum test was performed to detect differences in MRI findings in patients with and those without aseptic lymphocytic vasculitis-associated lesions. RESULTS Synovitis was detected in 77.4% of resurfacing arthroplasty hips and 86.2% of THA hips. Extracapsular disease was present in 6.5% of resurfacing arthroplasty hips and 10.3% of THA hips. Osteolysis was detected in 9.7% of resurfacing arthroplasty hips and 24.1% of THA hips. There was no difference in the incidence of synovitis (p=0.51), osteolysis (p=0.17), or extracapsular disease (p=0.67) between the resurfacing arthroplasty and THA groups. Patients with aseptic lymphocytic vasculitis-associated lesions had higher volumes of synovitis (p=0.04) than patients without aseptic lymphocytic vasculitis-associated lesions. Extracapsular disease and muscle edema were seen only in patients with aseptic lymphocytic vasculitis-associated lesions. CONCLUSION Synovitis is common in patients with metal-on-metal hip prostheses and occurs with a similar incidence after resurfacing arthroplasty and after THA; osteolysis and extracapsular disease are uncommon. The MRI signs most suggestive of aseptic lymphocytic vasculitis-associated lesions are high volumes of synovitis, extracapsular disease, and intramuscular edema.
Developing a Radiative Shock Experiment Relevant to Astrophysics

We report on the initial results of experiments being developed on the Falcon laser to simulate radiative astrophysical shocks. Cylindrically diverging blast waves were produced in low-density (~1018 cm-3), high-Z gas by laser-irradiating Xe gas jets containing atomic clusters. The blast-wave trajectory was measured by Michelson interferometry. The velocity for the blast wave is slightly less than the adiabatic Sedov-Taylor prediction, and an ionization precursor is observed ahead of the shock front. This suggests energy loss through radiative cooling and reduced compression due to preheat deposited ahead of the shock, both consistent with one-dimensional radiation hydrodynamics simulations.
Simulating Water-Use Efficiency of Piceacrassi folia Forest under Representative Concentration Pathway Scenarios in the Qilian Mountains of Northwest China

The current study used the Biome-Bio Geochemical Cycle (Biome-BGC) model to simulate water-use efficiency (WUE) of Piceacrassi folia (P. crassifolia) forest under four representative concentration pathway (RCP) scenarios, and investigated the responses of forest WUE to different combinations of climatic changes and CO2 concentrations in the Qilian Mountains of Northwest China. The model was validated by comparing simulated forest net primary productivity and transpiration under current climatic condition with independent field-measured data. Subsequently, the model was used to predict P. crassi folia forest WUE response to different climatic and CO2 change scenarios. Results showed that (1) increases in temperature, precipitation and atmospheric CO2 concentrations led to associated increases in WUE (ranging from 54% to 66% above the reference climate); (2) effect of CO2 concentration (increased WUE from 36% to 42.3%) was more significant than that of climate change (increased WUE from 2.4% to 15%); and (3) forest WUE response to future global change was more intense at high elevations than at low ones, with CO2 concentration being the main factor that controlled forest WUE variation. These results provide valuable insight to help understand how these forest types might respond to future changes in climate and atmospheric CO2 concentration.
Effects of mill type and particle size uniformity on growth performance, nutrient digestibility, and stomach morphology in finishing pigs.

The effects of particle size uniformity and mill type used to grind corn were determined in three experiments. In Exp. 1, 120 pigs (47.8 kg initial BW) were used. Treatments were 1) a 40:60 blend of coarsely rolled (in a roller mill) and finely ground (in a hammermill) corn with a large standard deviation (sgw) of particle size (sgw of 2.7), 2) hammermilled corn with an sgw of 2.3, and 3) roller-milled corn with an sgw of 2.0. Mean particle size of the corn was approximately 850 microns for all treatments. Growth performance was not affected (P > .11); but, stomach keratinization tended to be less severe (P < .08) and apparent nutrient digestibilities were greater (P < .008) when the sgw was smaller. In Exp. 2, 128 pigs (55.3 kg initial BW) were used. Treatments were corn ground in a hammermill and a roller mill to 800 and 400 microns. Pigs fed corn ground to 400 microns were more efficient (P < .004) and had greater apparent digestibilities of DM, N, and GE (P < .001) than pigs fed corn ground to 800 microns. Mill type did not affect growth performance (P > .40), but pigs fed corn ground in the roller mill had greater apparent nutrient digestibilities (P < .008). In Exp. 3, 128 pigs (67.3 kg initial BW) were used. Treatments were corn ground to 400 microns in a hammermill and a roller mill fed in meal and pelleted forms. Pigs fed pelleted diets had greater ADG (P < .003) and gain/feed (P < .03) but also had greater incidence of ulcers (P < .04). Pigs fed roller-milled corn were more efficient (P < .05) and had a lower incidence of ulcers (P < .04), but diets with hammermilled corn had lower sgw and greater apparent digestibilities of nutrients (P < .02). Our results suggest that mill type had inconsistent effects on growth performance, but more uniform particle sizes consistently gave greater nutrient digestibilities.
Analysis of Gene Expression Profiles in the Human Brain Stem, Cerebellum and Cerebral Cortex

The human brain is one of the most mysterious tissues in the body. Our knowledge of the human brain is limited due to the complexity of its structure and the microscopic nature of connections between brain regions and other tissues in the body. In this study, we analyzed the gene expression profiles of three brain regions—the brain stem, cerebellum and cerebral cortex—to identify genes that are differentially expressed among these different brain regions in humans and to obtain a list of robust, region-specific, differentially expressed genes by comparing the expression signatures from different individuals. Feature selection methods, specifically minimum redundancy maximum relevance and incremental feature selection, were employed to analyze the gene expression profiles. Sequential minimal optimization, a machine-learning algorithm, was employed to examine the utility of selected genes. We also performed a literature search, and we discuss the experimental evidence for the important physiological functions of several highly ranked genes, including NR2E1, DAO, and LRRC7, and we give our analyses on a gene (TFAP2B) that have not been investigated or experimentally validated. As a whole, the results of our study will improve our ability to predict and understand genes related to brain regionalization and function.
Clarifying the Relation Between Extraversion and Positive Affect.

This article clarifies two sources of ambiguity surrounding the relation between extraversion and positive affect. First, positive affect is defined differently across major models of the structure of affect. Second, no previous research has examined potentially diverging associations of lower-order aspects of extraversion (i.e., assertiveness and enthusiasm) with positive affect. Australian (Study 1: N = 437, 78% female, Mage = 20.41) and American (Study 2: N = 262, 39% female, Mage = 33.86) participants completed multiple measures of extraversion and positive affect. Correlations were employed to examine relations among these measures. In both studies, extraversion was most clearly associated with positive affect as conceptualized within a major factor model of affect-specifically, as positive activation (Watson & Tellegen, 1985)-rather than the valence-based conceptualization of positive affect provided by a circumplex model of affect (Russell, 1980). This was also the case for the assertiveness and enthusiasm aspects of extraversion. Our findings clarify the nature of the positive affective component of extraversion, which is best described in terms of both positive valence and high activation.