Miracle-dz/UniFAR-FTUs huggingface dataset:
Heritability and GWAS Studies for Monocyte–Lymphocyte Ratio

The monocyte–lymphocyte ratio (MLR) is a useful biomarker for disease development, but little is known about the extent to which genetic and environmental factors influence MLR variation. Here, we study the genetic architecture of MLR and determine the influence of demographic and lifestyle factors on MLR in data from a Dutch non-patient twin-family population. Data were obtained in 9,501 individuals from the Netherlands Twin Register. We used regression analyses to determine the effects of age, sex, smoking, and body mass index (BMI) on MLR and its subcomponents. Data on twins, siblings and parents (N = 7,513) were analyzed by genetic structural equation modeling to establish heritability and genome wide single nucleotide polymorphism (SNP) data from a genotyped subsample (N = 5,892) and used to estimate heritability explained by SNPs. SNP and phenotype data were also analyzed in a genome-wide association study to identify the genes involved in MLR. Linkage disequilibrium (LD) score regression and expression quantitative trait loci (eQTL) analyses were performed to further explore the genetic findings. Results showed that age, sex, and age × sex interaction effects were present for MLR and its subcomponents. Variation in MLR was not related to BMI, but smoking was positively associated with MLR. Heritability was estimated at 40% for MLR, 58% for monocyte, and 58% for lymphocyte count. The Genome-wide association study (GWAS) identified a locus on ITGA4 that was associated with MLR and only marginally significantly associated with monocyte count. For monocyte count, additional genetic variants were identified on ITPR3, LPAP1, and IRF8. For lymphocyte count, GWAS provided no significant findings. Taking all measured SNPs together, their effects accounted for 13% of the heritability of MLR, while all known and identified genetic loci explained 1.3% of variation in MLR. eQTL analyses showed that these genetic variants were unlikely to be eQTLs. In conclusion, variation in MLR level in the general population is heritable and influenced by age, sex, and smoking. We identified gene variants in the ITGA4 gene associated with variation in MLR. The significant SNP-heritability indicates that more genetic variants are likely to be involved.
Effects of Walking Endurance Reduction on Gait Stability in Patients with Stroke

Control of gait is usually altered following stroke, and it may be further compromised by overexertion and fatigue. This study aims to quantitatively assess patients' gait stability during six-minute walking, measuring upper body accelerations of twenty patients with stroke (64 ± 13 years old) and ten age-matched healthy subjects (63 ± 10 years old). Healthy subjects showed a steady gait in terms of speed and accelerations over the six minutes. Conversely, the patients unable to complete the test (n = 8) progressively reduced their walking speed (−22 ± 11%, confidence interval CI95%: −13, −29%, P = 0.046). Patients able to complete the test (n = 12) did not vary their walking speed over time (P = 0.493). However, this ability was not supported by an adequate capacity to maintain their gait stability, as shown by a progressive increase of their upper body accelerations (+5 ± 11%, CI95%: −1; +12%, P = 0.010). Walking endurance and gait stability should be both quantitatively assessed and carefully improved during the rehabilitation of patients with stroke.
Local and Systemic Responses in Matrix Metalloproteinase 8-Deficient Mice during Porphyromonas gingivalis-Induced Periodontitis

ABSTRACT Periodontitis is a bacterium-induced chronic inflammation that destroys tissues that attach teeth to jaw bone. Pathologically excessive matrix metalloproteinase 8 (MMP-8) is among the key players in periodontal destruction by initiating type I collagen degradation. We studied MMP-8 in Porphyromonas gingivalis-induced periodontitis by using MMP-8-deficient (MMP8−/−) and wild-type (WT) mice. Alveolar bone loss, inflammatory mediator expression, serum immunoglobulin, and lipoprotein responses were investigated to clarify the role of MMP-8 in periodontitis and systemic inflammatory responses. P. gingivalis infection induced accelerated site-specific alveolar bone loss in both MMP8−/− and WT mice relative to uninfected mice. The most extensive bone degradation took place in the P. gingivalis-infected MMP8−/− group. Surprisingly, MMP-8 significantly attenuated (P < 0.05) P. gingivalis-induced site-specific alveolar bone loss. Increased alveolar bone loss in P. gingivalis-infected MMP8−/− and WT mice was associated with increase in gingival neutrophil elastase production. Serum lipoprotein analysis demonstrated changes in the distribution of high-density lipoprotein (HDL) and very-low-density lipoprotein (VLDL) particles; unlike the WT mice, the MMP8−/− mice underwent a shift toward a smaller HDL/VLDL particle sizes. P. gingivalis infection increased the HDL/VLDL particle size in the MMP8−/− mice, which is an indicator of lipoprotein responses during systemic inflammation. Serum total lipopolysaccharide activity and the immunoglobulin G-class antibody level in response to P. gingivalis were significantly elevated in both infected mice groups. Thus, MMP-8 appears to act in a protective manner inhibiting the development of bacterium-induced periodontal tissue destruction, possibly through the processing anti-inflammatory cytokines and chemokines. Bacterium-induced periodontitis, especially in MMP8−/− mice, is associated with systemic inflammatory and lipoprotein changes that are likely involved in early atherosclerosis.
Perceived Risk, Price And Online Travel Agencies: Does Price Always Matter?

The present study analyzes the influence of price level in the case of online shopping for travel services. The methodology used is a quasi experiment developed in the online environment. The analysis is made within groups and follows three scenarios which depend on the level of brand awareness. Inside each scenario price takes two levels: similar to competition and smaller than competition. Results show that price does not have an influence on all types of perceived risk and that its influence depends also on the brand awareness component.
Website characteristics, Trust and purchase intention in online stores: - An Empirical study in the Indian context

Lack of trust in online transactions has been cited, by past scholars, as the main reason for the abhorrence of online shopping. In this paper we proposed a model and provided empirical evidence on the impact of the website characteristics on trust in online transactions in Indian context. In the first phase, we identified and empirically verified the relative importance of the website factors that develop online trust in India. In the next phase, we have tested the mediator effect of trust in the relationship between the website factors and purchase intention (and perceived risk). The present study for the first time provided empirical evidence on the mediating role of trust in online shopping among Indian customers.
Inequality, Incomplete Contracts, and the Size Distribution of Business Firms

This article analyzes the effects of intrafirm bargaining on the formation of firms in an economy with imperfect capital markets and contracting constraints. In equilibrium, wealth inequality induces a heterogeneous distribution of firm sizes, allowing for firms both too small and too large in terms of technical efficiency. The findings connect well to empirical facts such as the missing middle of firm-size distributions in developing countries. The model can encompass a nonmonotonic relationship between aggregate output and inequality. It turns out that an inflow of capital may indeed decrease output in absolute terms.
IMAGE-BASED SURFACE MEASUREMENT FOR CLOSE-RANGE HERITAGE DOCUMENTATION

Recent new developments in the electronics have leaded to the manufacturing of new high-resolution digital sensors (up to 39 mega pixel) for terrestrial cameras. These technological innovations, together with new processing algorithms of image matching, allow to obtain image-based surface models in an almost automatic way with an accuracy and a detail level that can be surely compared with the one achievable with active sensors. With this in mind, we present new developments in terrestrial 3D surface reconstruction and object modeling using digital images, reporting some tests conducted using low cost digital cameras and commercial or in-house software. The tests were conducted selecting different kinds of objects (low relief, statue, buildings, small heritage find, etc.), with different camera configurations and different image resolutions. Different image matching procedures are analyzed, comparing area-based, feature-based or an integration of both. A critical examination of the results is presented, with particular attention to the daily archaeological or heritage documentation purpose.
A L1-band dual-mode RF receiver for GPS and Galileo in 0.18μm CMOS

A dual-mode RF receiver with low-IF architecture has been developed for L1-band GPS and Galileo in a 0.18 mum CMOS process. The channel selecting bandpass filter centered at 4.092 MHz has programmable bandwidth (2MHz, 4 MHZ, and 6 MHz), which allows the reception of GPS and Galileo signals. A fractional-N phase locked loop generates local oscillator, allowing multiple reference clock frequencies. The noise figure of the receiver is 4.5 dB while consuming 41.4 mW from a 1.8 V supply. The image signal is rejected by more than 34 dB.
Translating Institutional Logics: When the Media Logic Meets Professions

This article presents results from a case study of media activities in a Swedish governmental agency where we illustrate a) how the media logic is translated and become embedded in the studied agency, and b) how different professional groups inside the organization shape the translation process. Theoretically we do this by re-visiting the notion of translation. Translation theory focuses on the local enactment and embeddedness of institutional models, ideals and practices. Institutional logics literature, on the other hand, focuses on the creation and flow of field-level meaning systems. By combining these two theoretical perspectives we are able to form a framework for understanding the local embeddedness and enactment of field-level institutional logics. The result of our study suggests that institutional logics – once they become introduced in a given context – consist of four elements that are interpreted and enacted differently inside organizations. We identify three local, profession-based value systems that shape the translation of the media logics, and we use this finding to theorize the role of professional value systems in shaping local translation processes.
Statistical image properties of print advertisements, visual artworks and images of architecture

Most visual advertisements are designed to attract attention, often by inducing a pleasant impression in human observers. Accordingly, results from brain imaging studies show that advertisements can activate the brain's reward circuitry, which is also involved in the perception of other visually pleasing images, such as artworks. At the image level, large subsets of artworks are characterized by specific statistical image properties, such as a high self-similarity and intermediate complexity. Moreover, some image properties are distributed uniformly across orientations in the artworks (low anisotropy). In the present study, we asked whether images of advertisements share these properties. To answer this question, subsets of different types of advertisements (single-product print advertisements, supermarket and department store leaflets, magazine covers and show windows) were analyzed using computer vision algorithms and compared to other types of images (photographs of simple objects, faces, large-vista natural scenes and branches). We show that, on average, images of advertisements and artworks share a similar degree of complexity (fractal dimension) and self-similarity, as well as similarities in the Fourier spectrum. However, images of advertisements are more anisotropic than artworks. Values for single-product advertisements resemble each other, independent of the type of product promoted (cars, cosmetics, fashion or other products). For comparison, we studied images of architecture as another type of visually pleasing stimuli and obtained comparable results. These findings support the general idea that, on average, man-made visually pleasing images are characterized by specific patterns of higher-order (global) image properties that distinguish them from other types of images. Whether these properties are necessary or sufficient to induce aesthetic perception and how they correlate with brain activation upon viewing advertisements remains to be investigated.
THE SCUBA-2 COSMOLOGY LEGACY SURVEY: ULTRALUMINOUS STAR-FORMING GALAXIES IN A z = 1.6 CLUSTER

We analyze new SCUBA-2 submillimeter and archival SPIRE far-infrared imaging of a z = 1.62 cluster, Cl 0218.3−0510, which lies in the UKIRT Infrared Deep Sky Survey/Ultra-Deep Survey field of the SCUBA-2 Cosmology Legacy Survey. Combining these tracers of obscured star-formation activity with the extensive photometric and spectroscopic information available for this field, we identify 31 far-infrared/submillimeter-detected probable cluster members with bolometric luminosities ≳1012 L☉ and show that by virtue of their dust content and activity, these represent some of the reddest and brightest galaxies in this structure. We exploit ALMA submillimeter continuum observations, which cover one of these sources, to confirm the identification of a SCUBA-2-detected ultraluminous star-forming galaxy in this structure. Integrating the total star-formation activity in the central region of the structure, we estimate that it is an order of magnitude higher (in a mass-normalized sense) than clusters at z ∼ 0.5–1. However, we also find that the most active cluster members do not reside in the densest regions of the structure, which instead host a population of passive and massive, red galaxies. We suggest that while the passive and active populations have comparable near-infrared luminosities at z = 1.6, MH ∼ −23, the subsequent stronger fading of the more active galaxies means that they will evolve into passive systems at the present day that are less luminous than the descendants of those galaxies that were already passive at z ∼ 1.6 (MH ∼ −20.5 and MH ∼ −21.5, respectively, at z ∼ 0). We conclude that the massive galaxy population in the dense cores of present-day clusters were already in place at z = 1.6 and that in Cl 0218.3−0510 we are seeing continuing infall of less extreme, but still ultraluminous, star-forming galaxies onto a pre-existing structure.
A Toeplitz displacement method for blind multipath estimation for long code DS/CDMA signals

The problem of blind channel identification for direct-sequence/code-division multiple-access (DS/CDMA) multiuser systems is explored. For wideband DS/CDMA signals, multipath distortion is well modeled by a finite-impulse response filter. In this work, a blind channel identification technique based on second-order statistics is investigated. The method exploits knowledge of the spreading code of the user of interest via matched filtering, as well as properties of spreading codes. The current scheme focuses on a method appropriate for randomized long sequence DS/CDMA. This access scheme poses special challenges as the spreading codes are time varying. An analytical approximation of the mean-squared error is derived using perturbation techniques. The performance of the algorithm is studied via simulation and through the mean-squared error approximation, which is observed to be tight.
Pink1 Rescues Gal4-Induced Developmental Defects in the Drosophila Eye

Parkinson disease pathology often includes the presence of ubiquitin-positive, α-synuclein-enriched inclusions in the remaining neurons. Pink1 (also identified as PARK6) encodes a serinethreonine kinase involved in mitochondrial protection that works with parkin to ubiquitinate various proteins, promoting mitophagy. The parkin protein works to tag cystolic proteins for degradation, and previous work in our laboratory has shown the ability of parkin to rescue a Gal4-induced phenotype. To further investigate the role of Pink1 in protection against toxic proteins, we have performed expression studies to determine the effects of increases and decreases in Pink1 on the Gal4-induced phenotype consisting of developmental defects in the Drosophila eye. Our results show that Pink1 is able to rescue the Gal4-induced phenotype, highlighting a protective role for Pink1 against toxic proteins. When expressing low levels of Gal4, reductions in Pink1 or parkin are not able to induce a phenotype. This suggests that Pink1 or parkin may counter Gal4 effects despite reductions, or that the effects of low level Gal4 may be alleviated by an alternative mechanism. Moreover, the Pink1 mechanism of action during differing types of cell stress, including degradation of toxic proteins, warrants further investigation.
Pain Modulation in Waking and Hypnosis in Women: Event-Related Potentials and Sources of Cortical Activity

Using a strict subject selection procedure, we tested in High and Low Hypnotizable subjects (HHs and LHs) whether treatments of hypoalgesia and hyperalgesia, as compared to a relaxation-control, differentially affected subjective pain ratings and somatosensory event-related potentials (SERPs) during painful electric stimulation. Treatments were administered in waking and hypnosis conditions. LHs showed little differentiation in pain and distress ratings between hypoalgesia and hyperalgesia treatments, whereas HHs showed a greater spread in the instructed direction. HHs had larger prefrontal N140 and P200 waves of the SERPs during hypnotic hyperalgesia as compared to relaxation-control treatment. Importantly, HHs showed significant smaller frontocentral N140 and frontotemporal P200 waves during hypnotic hypoalgesia. LHs did not show significant differences for these SERP waves among treatments in both waking and hypnosis conditions. Source localization (sLORETA) method revealed significant activations of the bilateral primary somatosensory (BA3), middle frontal gyrus (BA6) and anterior cingulate cortices (BA24). Activity of these contralateral regions significantly correlated with subjective numerical pain scores for control treatment in waking condition. Moreover, multivariate regression analyses distinguished the contralateral BA3 as the only region reflecting a stable pattern of pain coding changes across all treatments in waking and hypnosis conditions. More direct testing showed that hypnosis reduced the strength of the association of pain modulation and brain activity changes at BA3. sLORETA in HHs revealed, for the N140 wave, that during hypnotic hyperalgesia, there was an increased activity within medial, supramarginal and superior frontal gyri, and cingulated gyrus (BA32), while for the P200 wave, activity was increased in the superior (BA22), middle (BA37), inferior temporal (BA19) gyri and superior parietal lobule (BA7). Hypnotic hypoalgesia in HHs, for N140 wave, showed reduced activity within medial and superior frontal gyri (BA9,8), paraippocampal gyrus (BA34), and postcentral gyrus (BA1), while for the P200, activity was reduced within middle and superior frontal gyri (BA9 and BA10), anterior cingulate (BA33), cuneus (BA19) and sub-lobar insula (BA13). These findings demonstrate that hypnotic suggestions can exert a top-down modulatory effect on attention/preconscious brain processes involved in pain perception.
The Welfare Implications of Fiscal Dominance

This paper studies the interdependence between fiscal and monetary policy in a DSGE model with sticky prices and non-zero trend inflation. We characterize the fiscal and monetary policies by a rule whereby a given fraction k of the government debt must be backed by the discounted value of current and future primary surpluses. The remaining fraction of debt is backed by seigniorage revenues. When k = 1, there is no fiscal dominance, since the fiscal authority backs all debt and accommodates (independent) monetary policy, by adjusting current or future primary surpluses to satisfy the government’s intertemporal budget constraint. If k = 0, all debt is backed by the monetary authority and there is complete fiscal dominance. A continuum of possibilities lies between these two polar cases. We numerically show that: 1) the degree of fiscal dominance, as measured by (1 - k), is positively related to trend inflation, and 2) when prices are sticky, k has significant effects on the business cycle dynamics. The model is estimated using Bayesian techniques. Estimates of k imply a high degree of fiscal dominance in both Mexico and South Korea, but almost no fiscal dominance in Canada and the U.S. The country-specific estimates of the structural parameters are used in a second-order approximation of the equilibrium around the deterministic steady-state to evaluate the welfare costs of fiscal dominance. Results suggest significant welfare losses for countries with high degrees of fiscal dominance.
Towards a model of statistical machine translation Arabic-French

The automatic translation of texts of human origin is a very complex application called to apprehend the universe open text, without any constraint on their nature or diversity. To solve this problem, several attempts have been initiated, each having the objective to obtain a better translation quality of the parallel corpora. But before the various ambiguities of the natural language, the problem of translation is far from easy to solve. To do this, and in order to increase the translation quality, we propose a model for the generation of different semantic cases relating to different components of the sentence to determine the meaning first and then generate the translation into the language target. This allowed us to obtain satisfactory results compared to similar studies using other techniques. In our approach, we used a model guided by the semantics to learn the techniques of translation with a similar human performance. Our project is to translate source sentences from Arabic to French through a statistical approach that includes a dictionary and that is automatically evaluated by the BLEU metric to ensure encouraging results even if the tools that we use are very limited.