Miracle-dz/UniFAR-FTUs huggingface dataset:
A compact UWB sub-nanosecond pulse generator for microwave radar sensor with ringing miniaturization

This paper presents a compact ultra-wideband (UWB) microwave radar transmitter. The developed design presents low-power and low-cost ultra-short pulse with a minimum of the ringing in the output waveform. Ultra-short pulse has been generated by avalanche pulse generator and sharpened with a step recovery diode (SRD). In order to improve the simulation response and to increase the rise-time of the pulses, a new model of a step recovery diode (SRD) was used as a sharpener circuit. Making the discharge path as short as possible, a minimum of the ringing has been obtained in the output pulse, around 3,6% in overshoot. Compact pulse generator circuit structure is completely fabricated using low-cost microstrip technology characteristic. The measurement results present generator Gaussian wave form pulses over 6.4 V in amplitude and 440 fall time at 100 KHz. Good Agreements between the measured and calculated result are achieved.
Oscillator Realization of Higher-U ( N + , N − )-Spin Lie Algebras of W ∞-type and Quantized Symplectic Diffeomorphisms ∗

This article is a further contribution to our research [1] into a class of infinite-dimensional Lie algebras L∞(N+, N−) generalizing the standard W∞ algebra, viewed as a tensor operator algebra of SU(1, 1) in a group-theoretic framework. Here we interpret L∞(N+, N−) either as a infinite continuation of pseudo-unitary symmetries U(N+, N−), or as a “higher-U(N+, N−)-spin extension” of the diffeomorphism algebra diff(N+, N−) of a N = N+ + N− dimensional manifold. We also provide a deeper mathematical interconnection between Poisson (and symplectic diffeomorphism) algebras of functions on coadjoint orbits of pseudo-unitary groups U(N+, N−) and the classical limit of the corresponding tensor operator (and group) algebras. As potential applications, we comment on the formulation of integrable higher-dimensional dynamical (field) systems and gauge theories of higher-extended objects. Some remarks on non-commutative geometry are also made. PACS: 02.20. Tw, 02.20. Sv, 11.25. Hf, 03.65. Fd, 02.40. Gh
Query Answering in the Horn Fragments of the Description Logics SHOIQ and SROIQ

The high computational complexity of the expressive Description Logics (DLs) that underlie the OWL standard has motivated the study of their Horn fragments, which are usually tractable in data complexity and can also have lower combined complexity, particularly for query answering. In this paper we provide algorithms for answering conjunctive 2-way regular path queries (2CRPQs), a non-trivial generalization of plain conjunctive queries, in the Horn fragments of the DLs SHOIQ and SROIQ underlying OWL 1 and OWL 2. We show that the combined complexity of the problem is ExpTime-complete for Horn-SHOIQ and 2ExpTime- complete for the more expressive Horn-SROIQ, but is PTime-complete in data complexity for both. In contrast, even decidability of plain conjunctive queries is still open for full SHOIQ and SROIQ. These are the first completeness results for query answering in DLs with inverses, nominals, and counting, and show that for the considered logics the problem is not more expensive than standard reasoning.
Learning Style Adaptations and the Effect on Sight Word Recognition Achievement of Students with Learning Disabilities

The purpose of the study was to investigate the sight word recognition of two students with learning disabilities from a private school in Virginia, after adaptations to their learning styles had been made. The experimental design used to assess the effects of learning style adaptations on sight word recognition was a multiple probe across word groups. A combination of the Dolch and Fry Sight Word Lists determined the unmastered sight words for both subjects. The Dunn and Dunn Learning Style Inventory was used to identify the subjects' preferred learning style. The results of the study indicated that when adaptations were made for individual learning styles (i.e., auditory, visual, tactile, and kinesthetic) sight word recognition increased for both subjects. ,rJ: D 'U ,0 Q ;-n . ;,;_; \ \-,_, I J '; -J, JJ, 0 D D 01 0, Q, D 0 o. D Learning Styles 3
A Two-Stage Resolution Search-Based Heuristic for the Team Orienteering Problem

In this paper we propose to solve the Team Orienteering Problem (TOP) by using a two-stage resolution search-based heuristic. An instance of the TOP can be viewed as a variant of the well-known vehicle routing problem where the aim is to collect maximum scores by some or all members belonging to the team at the control points. Moreover, each of the provided path is limited and restricted by its predefined time window. The proposed approach combines two complementary stages. A first stage which is applied in order to construct a starting path that is considered as an elite path. A second stage is used for building a feasible solution for the TOP. Computational results, based on some benchmark instances of the literature, show that the proposed approach is competitive and it is able to provide new solutions within reasonable runtimes.
Integrated LC-MS/MS Analytical Systems and Physical Inspection for the Analysis of a Botanical Herbal Preparation

The herbal decoction process is generally inconvenient and unpleasant. To avoid using herbal medicine decoctions, various high-quality industrial and pharmaceutical herbal decoction products have been used in clinical applications for more than ten years in Taiwan. However, the consistency and standardization of the quality of these herbal medicines are goals that remain to be achieved. The aim of study was to develop a validated liquid chromatography-tandem electrospray ionization mass spectrometry (LC-MS/MS) method to determine the biomarkers astragaloside I, astragaloside IV, formononetin, cinnamic acid, paeoniflorin and gingerol in the herbal preparation known as Huangqi-Guizhi-Wuwu (HGW). To investigate the physical quality of HGW, methods such as scanning electron microscopy, light microscopy with Congo red and potassium iodine staining, solubility measurements, swelling power tests, and crude fiber analysis were used to identify additives in commercial pharmaceutical products. The optimal LC-MS/MS multiple reaction-monitoring system included a gradient program using 5 mM ammonium acetate buffer with 0.05% formic acid/methanol. The results demonstrate deviations in biomarker content across different brands. In addition to the herbal extract, starch and excipients in the pharmaceutical granule, and crushed crude herb powder was added to the pharmaceutical products to increase their herbal ingredient content. In conclusion, a rigorous examination should be performed to certify the quality of the herbal products.
Complex Predicates in Arrernte

Using the example of Murrinh-Patha, Seiss (2011) illustrates how Australian Aboriginal languages can shed light on the morphology-syntax interface: one aspect of their polysynthetic nature is that information often encoded in phrases and clauses in other languages is instead found in a single morphological word. In this paper, we look at another instance, the Australian Aboriginal language Arrernte, and in particular at complex predicates within the language, to examine the implications for the morphology-syntax interface. Following from this, we show how a glue semantics-based approach can be applied to Arrernte complex predicates, in a way that fits neatly with the use of glue semantics to model lexical functions in LFG in a multilingual natural language generation environment.
Acute Toxicity and Gastroprotective Role of M. pruriens in Ethanol-Induced Gastric Mucosal Injuries in Rats

The investigation was to evaluate gastroprotective effects of ethanolic extract of M. pruriens leaves on ethanol-induced gastric mucosal injuries in rats. Forty-eight rats were divided into 8 groups: negative control, extract control, ulcer control, reference control, and four experimental groups. As a pretreatment, the negative control and the ulcer control groups were orally administered carboxymethylcellulose (CMC). The reference control was administered omeprazole orally (20 mg/kg). The ethanolic extract of M. pruriens leaves was given orally to the extract control group (500 mg/kg) and the experimental groups (62.5, 125, 250, and 500 mg/kg). After 1 h, CMC was given orally to the negative and the extract control groups. The other groups received absolute ethanol. The rats were sacrificed after 1 h. The ulcer control group exhibited significant mucosal injuries with decreased gastric wall mucus and severe damage to the gastric mucosa. The extract caused upregulation of Hsp70 protein, downregulation of Bax protein, and intense periodic acid schiff uptake of glandular portion of stomach. Gastric mucosal homogenate showed significant antioxidant properties with increase in synthesis of PGE2, while MDA was significantly decreased. The ethanolic extract of M. pruriens leaves was nontoxic (<5 g/kg) and could enhance defensive mechanisms against hemorrhagic mucosal lesions.
Subtle Alterations of the Native Zinc Finger Structures Have Dramatic Effects on the Nucleic Acid Chaperone Activity of Human Immunodeficiency Virus Type 1 Nucleocapsid Protein

ABSTRACT The nucleocapsid protein (NC) of human immunodeficiency virus type 1 has two zinc fingers, each containing the invariant CCHC zinc-binding motif; however, the surrounding amino acid context is not identical in the two fingers. Recently, we demonstrated that zinc coordination is required when NC unfolds complex secondary structures in RNA and DNA minus- and plus-strand transfer intermediates; this property of NC reflects its nucleic acid chaperone activity. Here we have analyzed the chaperone activities of mutants having substitutions of alternative zinc-coordinating residues, i.e., CCHH or CCCC, for the wild-type CCHC motif. We also investigated the activities of mutants that retain the CCHC motifs but have mutations that exchange or duplicate the zinc fingers (mutants 1-1, 2-1, and 2-2); these changes affect amino acid context. Our results indicate that in general, for optimal activity in an assay that measures stimulation of minus-strand transfer and inhibition of nonspecific self-priming, the CCHC motif in the zinc fingers cannot be replaced by CCHH or CCCC and the amino acid context of the fingers must be conserved. Context changes also reduce the ability of NC to facilitate primer removal in plus-strand transfer. In addition, we found that the first finger is a more crucial determinant of nucleic acid chaperone activity than the second finger. Interestingly, comparison of the in vitro results with earlier in vivo replication data raises the possibility that NC may adopt multiple conformations that are responsible for different NC functions during virus replication.
Oscillations of Phospholipase C Activity Triggered by Depolarization and Ca2+ Influx in Insulin-secreting Cells*

Phospholipase C (PLC) is a ubiquitous enzyme involved in the regulation of a variety of cellular processes. Its dependence on Ca2+ is well recognized, but it is not known how PLC activity is affected by physiological variations of the cytoplasmic Ca2+ concentration ([Ca2+]i). Here, we applied evanescent wave microscopy to monitor PLC activity in parallel with [Ca2+]i in individual insulin-secreting INS-1 cells using the phosphatidylinositol 4,5-bisphosphate- and inositol 1,4,5-trisphosphate-binding pleckstrin homology domain from PLCδ1 fused to green fluorescent protein (PHPLCδ1-GFP) and the Ca2+ indicator fura red. In resting cells, PHPLCδ1-GFP was located predominantly at the plasma membrane. Activation of PLC by muscarinic or purinergic receptor stimulation resulted in PHPLCδ1-GFP translocation from the plasma membrane to the cytoplasm, detected as a decrease in evanescent wave-excited PHPLCδ1-GFP fluorescence. Using this translocation as a measure of PLC activity, we found that depolarization by raising extracellular [K+] triggered activation of the enzyme. This effect could be attributed both to a rise of [Ca2+]i and to depolarization per se, because some translocation persisted during depolarization in a Ca2+-deficient medium containing the Ca2+ chelator EGTA. Moreover, oscillations of [Ca2+]i resulting from depolarization with Ca2+ influx evoked concentration-dependent periodic activation of PLC. We conclude that PLC activity is under tight dynamic control of [Ca2+]i. In insulin-secreting β-cells, this mechanism provides a link between Ca2+ influx and release from intracellular stores that may be important in the regulation of insulin secretion.
The Influence of Pressure to Perform and Experience on Changing Perceptions and User Performance: A Multi-Method Experimental Analysis

To address shortcomings of predominately subjective measures in empirical IS research on IT usage and human-computer interaction, this paper uses a multi-method experimental analysis extending empirical surveying with objective measures from eye-tracking and electrodermal activity (EDA). In a three stage process, objective user performance is observed in terms of task fulfillment and user performing of participants in four focus groups, classified by user system experience and the treatment pressure to perform. Initial results of this research-in-progress reveal that users with prior system experience perform considerably better and faster than users without system experience. This also accounts for users under pressure to perform compared to users without pressure to perform. However, the results of the EDA show that users under pressure to perform also have a higher objective strain level. Furthermore, a first regression analysis outlines that objective performance might help to understand user's system satisfaction to a greater extent.
Review of the Usefulness of Various Rotational Seismometers with Laboratory Results of Fibre-Optic Ones Tested for Engineering Applications

Starting with descriptions of rotational seismology, areas of interest and historical field measurements, the fundamental requirements for rotational seismometers for seismological and engineering application are formulated. On the above basis, a review of all existing rotational seismometers is presented with a description of the principles of their operation as well as possibilities to fulfill formulated requirements. This review includes mechanical, acoustical, electrochemical and optical devices and shows that the last of these types are the most promising. It is shown that optical rotational seismometer based on the ring-laser gyroscope concept is the best for seismological applications, whereas systems based on fiber-optic gyroscopes demonstrate parameters which are also required for engineering applications. Laboratory results of the Fibre-Optic System for Rotational Events & Phenomena Monitoring using a small 1-D shaking table modified to generate rotational excitations are presented. The harmonic and time-history tests demonstrate its usefulness for recording rotational motions with rates up to 0.25 rad/s.
Chronic Hepatitis E Infection in a Persistently Immunosuppressed Patient Unable to Be Eliminated after Ribavirin Therapy

Recent case reports have shown that hepatitis E virus (HEV) infection can cause chronic hepatitis in immunosuppressed or immunocompromised patients. A 37-year-old woman suffered from prolonged elevation of aminotransferases after chemotherapy for Burkitt's lymphoma and was diagnosed with chronic hepatitis E due to a transfusion during chemotherapy. After an 8-month administration of ribavirin, complete HEV clearance was not achieved, likely due to prolonged hypogammaglobulinemia. This case indicates that HEV infection should be ruled out during liver dysfunction in immunosuppressed or immunocompromised patients and suggests that an alternative therapeutic strategy for such patients will be needed.
Assessing the performance limits of parallelized near-threshold computing

Supply voltage scaling has stagnated in recent technology nodes, leading to so-called “dark silicon. ” In this paper, we investigate the limit of voltage scaling together with task parallelization to maintain task completion latency. When accounting for parallelization overheads, minimum task energy is obtained at “near threshold” supply-voltages across 6 commercial technology nodes and provides 4X improvement in overall CMP performance.
Computational Fluid Dynamic Solver based on Cellular Discrete-Event Simulation

Computational Fluid Dynamics (CFD) deals with computing the equations of fluid flows using numerical methods. The Discrete-Event System specification (DEVS) theory has been used to approximate the continuous systems by applying a quantized state system approach. In this research, we employ Cellular DEVS theory (Cell-DEVS) – originally proposed for modeling and simulation of spatial environments – to create a uniform set of rules for CFD. This harmonized set of state changes can effectively render the fluid dynamics, by applying the accurate rule that represents the behavior of the fluid. The combination of the simplicity and the mathematical backbone allows for constructing models computable on an average computer or an array of cluster computers.
Effluents of Shrimp Farms and Its Influence on the Coastal Ecosystems of Bahía de Kino, Mexico

The impact on coastal ecosystems of suspended solids, organic matter, and bacteria in shrimp farm effluents is presented. Sites around Bahía de Kino were selected for comparative evaluation. Effluent entering Bahia Kino (1) enters Laguna La Cruz (2). A control site (3) was outside the influence of effluents. Water quality samples were collected every two weeks during the shrimp culture period. Our data show that the material load in shrimp farm effluents changes biogeochemical processes and aquatic health of the coastal ecosystem. Specifically, the suspended solids, particulate organic matter, chlorophyll a, viable heterotrophic bacteria, and Vibrio-like bacteria in the bay and lagoon were two- to three-fold higher than the control site. This can be mitigated by improvements in the management of aquaculture systems.
Regional Scheduler: A Region-based High Efficient Solid State Drive Scheduler

Currently, the available I/O schedulers in Linux kernel have long been designed and optimized under the default assumption of underlying traditional rotating HDDs. Unsurprisingly, their performance would be sub optimal when working with emerging Solid State Drives(SSD), which exhibit widely disparate operational characteristics than HDDs. In this study, we develop a new SSD scheduler which takes SSDs' peculiarities into account in its design. In more detail, firstly, we partition the entire SSD space into several regions as basic scheduling units and issue requests to them simultaneously to exploit internally rich parallelism. Secondly, we give preference to read requests over writes to take advantage of the fact that reads are much faster than writes, avoiding excessive read-blocked by-write interference. Lastly, within each region's scheduling queue, we sort write requests before issuing them in anticipation of transforming random writes to sequential patterns to avoid harmful random writes. Our evaluation results of a variety of workloads have demonstrated that Regional Scheduler is capable of improving the performance by 17-32% compared with the best of the four kernel I/O schedulers, in the meantime, improving SSD's lifetime because of the successful transformation of random writes to sequential writes.
The Schreber case: a reappraisal.

Reajustements theoriques de la theorie freudienne de la paranoia apres les decouvertes de William Niederland sur l'enfance de Daniel Paul Schreber le celebre paramoiaque, auteur des Memoires d'un Nevropathe dont Freud fit l'exegese en un article circonstancie, recueilli dans ses Cinq Psychanalyses
On character varieties of two‐bridge knot groups

We find explicit models for the PSL2(ℂ)‐ and SL2(ℂ)‐character varieties of the fundamental groups of complements in 𝕊3 of an infinite family of two‐bridge knots that contains the twist knots. We compute the genus of the components of these character varieties, and deduce upper bounds on the degree of the associated trace fields. We also show that these knot complements are fibered if and only if they are commensurable to a fibered knot complement in a ℤ/2ℤ‐homology sphere, resolving a conjecture of Hoste and Shanahan.
Influence Tactics for Effective Adaptive Selling

The adaptive selling literature identifies effective salespeople as those who match their influence tactics to suit the characteristics of buyers. However, prior research is largely silent on the specific influence tactics that salespeople use and the effectiveness of these tactics across different types of buyers. The authors propose a theoretical model that uses Kelman's (1961) underlying influence processes of internalization, compliance, and identification to identify the seller influence tactics that salespeople use and to assess which of these tactics will resonate with three types of buyers: task-oriented buyers, interaction-oriented buyers, and self-oriented buyers. The authors test their model with data from 193 bidirectionally matched buyer–seller dyads. The results strongly support the theoretical model and suggest that buyers are more complex than originally presumed. However, salespeople seem to recognize this complexity and use the combination of influence tactics prescribed by theory for persuading these types of buyers.
HIV Infection of Naturally Occurring and Genetically Reprogrammed Human Regulatory T-cells

A T-cell subset, defined as CD4+CD25hi (regulatory T-cells [Treg cells]), was recently shown to suppress T-cell activation. We demonstrate that human Treg cells isolated from healthy donors express the HIV-coreceptor CCR5 and are highly susceptible to HIV infection and replication. Because Treg cells are present in very few numbers and are difficult to expand in vitro, we genetically modified conventional human T-cells to generate Treg cells in vitro by ectopic expression of FoxP3, a transcription factor associated with reprogramming T-cells into a Treg subset. Overexpression of FoxP3 in naïve human CD4+ T-cells recapitulated the hyporesponsiveness and suppressive function of naturally occurring Treg cells. However, FoxP3 was less efficient in reprogramming memory T-cell subset into regulatory cells. In addition, FoxP3-transduced T-cells also became more susceptible to HIV infection. Remarkably, a portion of HIV-positive individuals with a low percentage of CD4+ and higher levels of activated T-cells have greatly reduced levels of FoxP3+CD4+CD25hi T-cells, suggesting disruption of the Treg cells during HIV infection. Targeting and disruption of the T-cell regulatory system by HIV may contribute to hyperactivation of conventional T-cells, a characteristic of HIV disease progression. Moreover, the ability to reprogram human T-cells into Treg cells in vitro will greatly aid in decoding their mechanism of suppression, their enhanced susceptibility to HIV infection, and the unique markers expressed by this subset.
Reviewing Microgrids from a Multi-Agent Systems Perspective

The construction of Smart Grids leads to the main question of what kind of intelligence such grids require and how to build it. Some authors choose an agent based solution to realize this intelligence. However, there may be some misunderstandings in the way this technology is being applied. This paper exposes some considerations of this subject, focusing on the Microgrid level, and shows a practical example through INGENIAS methodology, which is a methodology for the development of Agent Oriented systems that applies Model Driven Development techniques to produce fully functional Multi-Agent Systems.