Miracle-dz/UniFAR-FTUs huggingface dataset:
Oncotype DX ® Recurrence Score Accurately Predict the Risk of Recurrence in Breast Cancer ? A 10 Year Period Study in a Single Institution Vanda

The 21-gene Recurrence Score (RS) assay (Oncotype DX) predicts the risk of recurrence and benefit from chemotherapy in estrogen receptor (ER) positive, Her-2/neu negative, node negative and, more recently, limited nodepositive (<3) breast cancer. The 21-gene RS is divided into low, intermediate and high risk groups corresponding to a likelihood of recurrence within 10 years of initial diagnosis. Clinicians utilize 21-gene RS to guide treatment, particularly whether to add adjuvant chemotherapy to endocrine therapy. This study aimed to determine if 21-gene RS accurately predicts the rate of recurrence with respect to each category. A cohort of 236 patients was studied retrospectively and analyzed, based on correlation between histologic and immunohistochemical (IHC) findings versus 21-gene RS stratification in relation to clinical outcomes. In the cohort examined, no deaths occurred in all the patients studied. Six patients had recurrence or metastatic disease. Of these six patients, only one had been stratified to the high risk group by 21-gene RS analysis, while four were stratified to the low risk group, and one to the intermediate risk group. 21-gene RS accurately predicted 97% of the low RS stratified patients to avoid receiving chemotherapy. However, addition of chemotherapy in the treatment regimen for node positive, Her-2/neu positive, high Ki-67, and PR negative tumors may be beneficial regardless of 21-gene RS. Our investigation found that there is a high concordance rate between 21-gene RS and IHC of ER, progesterone receptor (PR), and Her-
Coordination control policy for mobile sensor networks with shared heterogeneous resources

This paper considers centralized coordination of cooperating heterogeneous wireless sensors with multiple shared resources. A discrete event controller (DEC) is used to sequence the most suitable tasks for stationary and mobile sensors according to the current perception of the environment, efficiently handling simultaneous missions of different priority. Its matrix formulation, apart from making the assignment of the mission planning straightforward and easily adaptable if agents or applications change, provides a powerful tool to analyze deadlock situations and implement efficient deadlock avoidance policies. It also represents a complete dynamical description of the system which allows computer simulation analysis. The matrix formulation also allows fast implementation of DEC for actual WSNs.
The emergence and implementation of health goals

Abstract Modern theorizing on goals is applied to an analysis of the implementation and the emergence of health goals. First, a model of action phases and its concomitant concepts of implemental mindsets and implementation intentions (Gollwitzer, 1990, 1993) are used to explore how the initiation of health goal directed behaviors can be facilitated and how the performance of health goal directed actions is enhanced. Second, recent theorizing on the psychology of thinking about the future (Oettingen, 1996; 1997) is employed to discuss conditions and processes of the emergence of health goals. It is suggested that contrasting positive fantasies about the future with reflections on the negative aspects of reality create binding health goals that reliably affect people's behaviors.
High-sensitivity wideband THz detectors based on GaN HEMTs with integrated bow-tie antennas

This paper reports on antenna-coupled field-effect transistors for the detection of terahertz radiation (Ter-aFETs), based on AlGaN/GaN high electron mobility transistors (HEMTs). The HEMTs are integrated on-chip with bow-tie antennas. The broadband sensitivity of the fabricated detectors was characterized in the frequency range from 0.4 up to 1.18 THz. We reach record values of optical noise equivalent power (NEP) down to 57 pW/√Hz at 0.9 THz. These values are the result of antenna and fabrication process optimization as well as modelling including plasmonic effects.
Bioinformatics Analysis of the Complete Genome Sequence of the Mango Tree Pathogen Pseudomonas syringae pv. syringae UMAF0158 Reveals Traits Relevant to Virulence and Epiphytic Lifestyle

The genome sequence of more than 100 Pseudomonas syringae strains has been sequenced to date; however only few of them have been fully assembled, including P. syringae pv. syringae B728a. Different strains of pv. syringae cause different diseases and have different host specificities; so, UMAF0158 is a P. syringae pv. syringae strain related to B728a but instead of being a bean pathogen it causes apical necrosis of mango trees, and the two strains belong to different phylotypes of pv.syringae and clades of P. syringae. In this study we report the complete sequence and annotation of P. syringae pv. syringae UMAF0158 chromosome and plasmid pPSS158. A comparative analysis with the available sequenced genomes of other 25 P. syringae strains, both closed (the reference genomes DC3000, 1448A and B728a) and draft genomes was performed. The 5.8 Mb UMAF0158 chromosome has 59.3% GC content and comprises 5017 predicted protein-coding genes. Bioinformatics analysis revealed the presence of genes potentially implicated in the virulence and epiphytic fitness of this strain. We identified several genetic features, which are absent in B728a, that may explain the ability of UMAF0158 to colonize and infect mango trees: the mangotoxin biosynthetic operon mbo, a gene cluster for cellulose production, two different type III and two type VI secretion systems, and a particular T3SS effector repertoire. A mutant strain defective in the rhizobial-like T3SS Rhc showed no differences compared to wild-type during its interaction with host and non-host plants and worms. Here we report the first complete sequence of the chromosome of a pv. syringae strain pathogenic to a woody plant host. Our data also shed light on the genetic factors that possibly determine the pathogenic and epiphytic lifestyle of UMAF0158. This work provides the basis for further analysis on specific mechanisms that enable this strain to infect woody plants and for the functional analysis of host specificity in the P. syringae complex.
Engagement of amygdala in third‐person view of face‐to‐face interaction

Humans often watch interactions between other people without taking part in the interaction themselves. Strikingly little is, however, known about how gestures and expressions of two interacting humans are processed in the observer's brain, since the study of social cues has mostly focused on the perception of solitary humans. To investigate the neural underpinnings of the third‐person view of social interaction, we studied brain activations of subjects who observed two humans either facing toward or away from each other. Activations within the amygdala, posterior superior temporal sulcus (pSTS), and dorsomedial prefrontal cortex (dmPFC) were sensitive to the interactional position of the observed people and distinguished humans facing toward from humans facing away. The amygdala was most sensitive to face‐to‐face interaction and did not differentiate the humans facing away from the pixelated control figures, whereas the pSTS dissociated both human stimuli from the pixel figures. The results of the amygdala reactivity suggest that, in addition to regulating interpersonal distance towards oneself, the amygdala is involved in the assessment of the proximity between two other persons. Hum Brain Mapp, 2012. © 2011 Wiley Periodicals, Inc.
Trading zones, boundary objects, and the pursuit of news innovation

Amid growing calls for greater collaboration between journalism and computer programming, this article examines a salient case study that reveals processes of communication, exchange, and work production at the intersection of these social and occupational worlds. We focus on a key stage of the Knight-Mozilla News Technology partnership – namely, an online ‘Learning Lab’ through which 60 individuals sought to coordinate around a shared interest in the innovation of journalism through open-source software. Drawing on the science and technology studies concepts of trading zones and boundary objects, we explore how distinct understandings about news and technology converged, diverged, and ultimately blended around three thematic ambitions: making news more process-oriented, participatory, and socially curated. This window onto boundary negotiations in journalism provides a glimpse into the future development of news and its norms and values, as programmers and their ethics assume a greater role in the journalistic field – in the very heart of some of its leading institutions.
Barcelona Economics Working Paper Series the Role of Model Uncertainty and Learning in the U.s. Postwar Policy Response to Oil Prices the Role of Model Uncertainty and Learning in the U.s. Postwar Policy Response to Oil Prices

This paper studies optimal monetary policy in a framework that explicitly accounts for policymakers' uncertainty about the channels of transmission of oil prices into the economy. More speci…cally, I examine the robust response to the real price of oil that US monetary authorities would have been recommended to implement in the period 1970 2009; had they used the approach proposed by Cogley and Sargent (2005b) to incorporate model uncertainty and learning into policy decisions. In this context, I investigate the extent to which regulators'changing beliefs over di¤erent models of the economy play a role in the policy selection process. The main conclusion of this work is that, in the speci…c environment under analysis, one of the underlying models dominates the optimal interest rate response to oil prices. This result persists even when alternative assumptions on the models'priors change the pattern of the relative posterior probabilities, and can thus be attributed to the presence of model uncertainty itself.
Taxing the Job Creators: Efficient Progressive Taxation with Wage Bargaining

The standard economic view of the personal income tax is that it is a distortionary way of raising revenue which nonetheless has value because it tends to increase equality. However, when wages deviate from marginal product, the laissez-faire equilibrium is inefficient, and there can be an independent efficiency rationale for income taxation. I study a setting of wage bargaining within hierarchical teams of workers and managers, and show that the efficiency case for taxing managers depends on a "job-creation" effect: if increased labour supply allows managers to supervise larger teams and thus collect larger rents, they will have an incentive to work too hard to create jobs at their firm. In other words, it is because of their job-creation activity that the "job creators" should be heavily taxed. Simulation of a calibrated model suggests an efficient tax schedule that is progressive over most of the income distribution with a top marginal rate of between 50% and 60%, and this result is not sensitive to the magnitude of the labour supply response to taxation. For a planner with redistributive motives, optimal marginal tax rates are also considerably higher at the top of the distribution in the presence of wage bargaining rather than a competitive labour market.
Properties and Modeling of Partial Conjunction / Disjunction

The partial conjunction/disjunction function (PCD) integrates conjunctive and disjunctive features in a single function. Special cases of this function include the pure conjunction, the pure disjunction, and the arithmetic mean. PCD enables a continuous transition from the pure conjunction to the pure disjunction, using a parameter that specifies a desired level of conjunction (andness) or disjunction (orness). In this paper, we investigate and compare various approaches to organize the PCD function. Our goal is to specify the most important necessary conditions that the PCD should satisfy. The next step would then be to derive the best version of PCD and use it to create other compound continuous logic functions. Key-Words: Continuous logic, preferences, andness, orness, partial conjunction/disjunction, andor, orand
Adolescents' Core Self-Evaluations as Mediators of the Effect of Mindfulness on Life Satisfaction

We examined the mediating role of Chinese adolescents’ core self-evaluations in the relationship between mindfulness and their life satisfaction. The participants ( N = 436) completed the Mindful Attention Awareness Scale, the Core Self-Evaluations Scale, and the Satisfaction with Life Scale. The results suggested that greater life satisfaction was associated with higher levels of mindfulness and more positive core self-evaluations, and core self- evaluations were positively correlated with life satisfaction. The results of mediation analysis suggested that core self-evaluations partially mediated the relationship between mindfulness and life satisfaction of Chinese adolescents, implying that a higher level of mindfulness was correlated with more positive core self-evaluations, which were finally associated with greater life satisfaction. Together these results imply that enhancing the levels of mindfulness and encouraging positive core self-evaluations of adolescents will exert a significantly positive effect in promoting their well-being.
Do workers with self-reported symptoms have an elevated risk of developing upper extremity musculoskeletal disorders three years later?

Objectives: Few prospective studies have evaluated outcomes of workers with self-reported symptoms of upper extremity musculoskeletal disorders (UEMSD). The objective was to study the three-year outcomes of workers with self-reported symptoms, with or without a positive physical examination. Methods: In 1993–4, 598 subjects highly exposed to repetitive work filled out a Nordic-style questionnaire. They underwent a standardised physical examination at that time and again in 1996–7 by the same occupational physician. The three-year outcomes (based on physical examination) of workers with a self-administered questionnaire positive at baseline for UEMSD, with or without a positive physical examination, were studied. Results: The three-year incidence rate was 44.1%; one third of these incident cases had self-reported symptoms in 1993–4. Workers with a positive questionnaire had a significantly higher risk of UEMSD at physical examination three years later (80.1% UEMSD cases with positive questionnaires n = 354, vs 44.2% cases without positive questionnaires n = 69, p<0.001). Moreover, workers with positive questionnaires but without UEMSD diagnosed in 1993–4 (n = 177) also had a significantly higher risk of UEMSD at physical examination three years later (60.5% cases with positive questionnaires n = 26, vs 38.8% cases without positive questionnaires n = 52, p = 0.01). Results were similar when gender and age were taken into account. Conclusion: Workers highly exposed to repetitive movements have a high risk of developing UEMSD and should be followed closely in surveillance programmes. Workers with self-reported symptoms without UEMSD diagnosed in physical examination represented only one third of new cases three years later. However, their risk of developing UEMSD was significantly increased, compared with those without symptoms.
Promptness : A Teaching and Evaluation Model

Promptness is a desirable behavior in students and an expected behavior in professionals. Promptness can also be viewed as a surrogate variable of the larger concept of engagement with the course. Here, a model to integrate the evaluation of promptness into the usual pattern of teaching a college-level course is presented. The life cycle of a specific assignment is presented and broken down into measurable intervals. Classroom management software provides the key tool to perform the analysis. Other forms of evaluation of promptness are presented. Conclusions are drawn, focusing on increasing learning by maximizing the time students have available between the opening of a posted assignment and its submission.
Chinese Nominal Entity Recognition with Semantic Role Labeling

Nominal entity recognition is a fundamental task in natural language processing. Semantic role labeling views a sentence as a predicate-arguments structure, which provides an alternative perspective for the boundary detection and type recognition of nominal entity. In this paper, we propose a nominal entity recognition method with semantic role labeling. First, a Maximum Entropy (ME) model is trained on unlabeled data to address the data sparse problem in acquiring the preferences for each pair of predicate and argument. Then, use the information of semantic role labeling as features in a high quality nominal entity model. The experiments on ACE 2004 Chinese data show that the proposed method improves the performance of the high quality nominal entity recognizer, and achieves higher accuracy and recall rate.
A new avian leukosis virus-based packaging cell line that uses two separate transcomplementing helper genomes

An avian leukosis virus-based packaging cell line was constructed from the genome of the Rous-associated virus type 1. The gag, pol, and env genes were separated on two different plasmids; the packaging signal and the 3' long terminal repeat were removed. On a plasmid expressing the gag and pol genes, the env gene was replaced by the hygromycin resistance gene. The phleomycin resistance gene was inserted in the place of the gag-pol genes on a plasmid expressing the env gene. The plasmid containing the gag, pol, and Hygror genes was transfected into QT6 cells. Clones that produced high levels of p27gag were transfected with the plasmid containing the Phleor and env genes. Clones that produced high levels of env protein (as measured by an interference assay) were tested for their ability to package NeoR-expressing replication-defective vectors (TXN3'). One of the clones (Isolde) was able to transfer the Neo+ phenotype to recipient cells at a titer of 10(5) resistance focus-forming units per ml. Titers of supernatants of cells infected with Rous-associated virus type 1 prior to transfection by Neor vectors were similar. Tests for recombination events that might result in intact helper virus showed no evidence for the generation of replication-competent virus. The use of selectable genes inserted next to the viral genes to generate high-producer packaging cell lines is discussed.
The Epistemic Culture of Homebrewers and Microbrewers

ABSTRACT Homebrewing and microbrewing have been growing in popularity during the last few decades. One way this phenomenon can be analyzed is through the culture of knowledge production. We use the subfield of science and technology studies (STS) to examine homebrewing and microbrewing in this light. Early STS was interested in the social construction of scientific facts within daily practices of scientists. Through these early studies, STS revealed not only the process of scientific fact creation but also existence of “epistemic cultures. ” Our study investigates the epistemic culture of homebrewers and microbrewers. Analysis of this epistemic culture was accomplished through use of in-depth interviews with homebrewers and microbrewers at several regional sites. Three major themes emerged from the data: home space as lab; the art and science of beer brewing; and brewing as “friendship”. These themes establish a foundation for understanding the shared epistemic culture existing between homebrewers and microbrewers.
Congenital Heart Defects and Developmental and Other Psychiatric Disorders: A Danish Nationwide Cohort Study

Background— We examined the risk of psychiatric in-patient admissions and out-patient visits among Danish patients with congenital heart defects (CHD). Methods and Results— Using the Danish National Registry of Patients, we identified CHD patients born January 1, 1977, to January 1, 2002. For each patient, we randomly selected 10 population-comparison cohort members from the Danish Civil Registration System, matched by sex and birth year. We computed cumulative risk and hazard ratios (HRs) of time to first psychiatric in-patient admission or out-patient visit identified in the Danish Psychiatric Central Registry and adjusted for parents' educational level and parents' psychiatric morbidity. We identified 6927 CHD patients. At 15 years of age, the cumulative risk of psychiatric admissions or out-patient visits was 5.9% (95% confidence interval [CI], 5.2%–6.6%) among CHD patients. The HRs for CHD patients and comparison cohort members aged 0 to 14 years were 1.8 (95% CI: 1.5–2.1) for males and 2.5 (95% CI: 2.0–3.1) for females. For patients aged 15 to 30 years, the HRs were 1.6 (95% CI: 1.2–2.0) for males and 1.0 (95% CI: 0.8–1.3) for females. Congenital heart defect patients, both with and without invasive therapeutic interventions or extracardiac defects or syndromes, had a higher risk of psychiatric in-patient admissions or out-patient visits than comparison cohort members. After restriction of the comparison cohort to patients with diabetes mellitus or asthma (n=2554), the HR was 1.41 (95% CI: 1.07–1.85) for patients aged 0 to 14 years and 0.70 (95% CI: 0.52–0.94) for patients aged 15 to 30 years. Conclusion— Congenital heart disease patients with or without invasive therapeutic interventions are at increased risk of developmental and other psychiatric disorders, which seem to develop earlier than in patients with diabetes mellitus or asthma.
Emergent phenomena from dynamic network models : mathematical analysis of EEG from people with IGE

In this thesis mathematical techniques and models are applied to electroencephalographic (EEG) recordings to study mechanisms of idiopathic generalised epilepsy (IGE). First, we compare network structures derived from resting-state EEG from people with IGE, their unaffected relatives, and healthy controls. Next, these static networks are combined with a dynamical model describing the activity of a cortical region as a population of phase-oscillators. We then examine the potential of the differences found in the static networks and the emergent properties of the dynamic network as individual biomarkers of IGE. The emphasis of this approach is on discerning the potential of these markers at the level of an individual subject rather than their ability to identify differences at a group level. Finally, we extend a dynamic model of seizure onset to investigate how epileptiform discharges vary over the course of the day in ambulatory EEG recordings from people with IGE. By perturbing the dynamics describing the excitability of the system, we demonstrate the model can reproduce discharge distributions on an individual level which are shown to express a circadian tone. The emphasis of the model approach is on understanding how changes in excitability within brain regions, modulated by sleep, metabolism, endocrine axes, or anti-epileptic drugs (AEDs), can drive the emergence of epileptiform activity in large-scale brain networks. Our results demonstrate that studying EEG recordings from people with IGE can lead to new mechanistic insight on the idiopathic nature of IGE, and may eventually lead to clinical applications. We show that biomarkers derived from dynamic network models perform significantly better as classifiers than biomarkers based on
A new protocol for the integration of voice and data over PRMA

A new scheme for the integration of voice and data based on PRMA is proposed. The voice and the data subsystems are logically separated. The total available bandwidth is divided into three regions-voice information, voice contention, and data regions. The bandwidth available for the data users depends on the fulfilling of the QOS requirements for the voice users, which is assumed to be a limit on the number of dropped voice packets. The voice subsystem has been modeled as a Markov chain and an optimization problem to maximize the bandwidth allocated for the data users has been formulated. Numerical results indicate that a significant amount of data traffic can be supported without sacrificing the voice capacity of the system.