Miracle-dz/UniFAR-FTUs huggingface dataset:
A coincidence of needs?: Employers and full‐time students

Employers’ demands for cheap and flexible labour which can multi‐task, make decisions and act responsibly are being met by an increasing supply of students to the part‐time labour market who are having to work due to financial necessity during term‐time. This article details the results of a survey and focus group study conducted at Manchester Metropolitan University in February 1999 addressing the nature of this employment relationship. Students’ employment provides them with advantages other than money – valuable work experience, the opportunity to meet people and to take on responsibility. Employers benefit from an easily recruited workforce of intelligent, articulate young people who are numerically and functionally flexible, conscientious, accepting relatively low pay, and who are easy to control. Potential conflict is indicated as students do articulate dislikes about their work and employment conditions, yet they feel unable to challenge their employers about them.
Machine Learning for Bioclimatic Modelling

Many machine learning (ML) approaches are widely used to generate bioclimatic models for prediction of geographic range of organism as a function of climate. Applications such as prediction of range shift in organism, range of invasive species influenced by climate change are important parameters in understanding the impact of climate change. However, success of machine learning-based approaches depends on a number of factors. While it can be safely said that no particular ML technique can be effective in all applications and success of a technique is predominantly dependent on the application or the type of the problem, it is useful to understand their behavior to ensure informed choice of techniques. This paper presents a comprehensive review of machine learning-based bioclimatic model generation and analyses the factors influencing success of such models. Considering the wide use of statistical techniques, in our discussion we also include conventional statistical techniques used in bioclimatic modelling.
Ischaemic preconditioning improves proteasomal activity and increases the degradation of δPKC during reperfusion

Aims The response of the myocardium to an ischaemic insult is regulated by two highly homologous protein kinase C (PKC) isozymes, δ and εPKC. Here, we determined the spatial and temporal relationships between these two isozymes in the context of ischaemia/reperfusion (I/R) and ischaemic preconditioning (IPC) to better understand their roles in cardioprotection. Methods and results Using an ex vivo rat model of myocardial infarction, we found that short bouts of ischaemia and reperfusion prior to the prolonged ischaemic event (IPC) diminished δPKC translocation by 3.8-fold and increased εPKC accumulation at mitochondria by 16-fold during reperfusion. In addition, total cellular levels of δPKC decreased by 60 ± 2.7% in response to IPC, whereas the levels of εPKC did not significantly change. Prolonged ischaemia induced a 48 ± 11% decline in the ATP-dependent proteasomal activity and increased the accumulation of misfolded proteins during reperfusion by 192 ± 32%; both of these events were completely prevented by IPC. Pharmacological inhibition of the proteasome or selective inhibition of εPKC during IPC restored δPKC levels at the mitochondria while decreasing εPKC levels, resulting in a loss of IPC-induced protection from I/R. Importantly, increased myocardial injury was the result, in part, of restoring a δPKC-mediated I/R pro-apoptotic phenotype by decreasing pro-survival signalling and increasing cytochrome c release into the cytosol. Conclusion Taken together, our findings indicate that IPC prevents I/R injury at reperfusion by protecting ATP-dependent 26S proteasomal function. This decreases the accumulation of the pro-apoptotic kinase, δPKC, at cardiac mitochondria, resulting in the accumulation of the pro-survival kinase, εPKC.
Effects of Intraoperative Blood Salvage on Leukocyte Recruitment to the Endothelium

Background:The contamination of salvaged wound blood with activated leukocytes has been suspected to play a role in leukocyte-mediated tissue injury by increased adhesion to the endothelium. To verify this hypothesis, the authors performed a clinical study to examine the effects of blood salvage on leukocyte–endothelial interactions. Methods:Expression of L-selectin, CD18, and CD11b and leukocyte adhesion to activated endothelium from human umbilical veins were measured in 25 patients undergoing major orthopedic surgery. Adhesion of fluorescently labeled leukocytes was examined in a flow chamber at shear rates of 50–1,600 s−1. Comparisons were made between samples from venous blood and from processed salvaged wound blood (SWB). Results:At 30% hematocrit, SWB contained 2,162 ± 147 leukocytes/&mgr;l. In comparison with venous blood, CD11b was up-regulated in SWB 1.3- to 3.6-fold on monocytes and neutrophils, whereas L-selectin and CD18 decreased on monocytes by 53% and 15%, respectively (P < 0.05). Despite up-regulation of CD11b, firm adhesion was significantly reduced by 74–76% in SWB. Rolling fractions and rolling velocities were significantly higher in SWB, and their relation to shear rate was markedly altered (P < 0.01). In addition, adherent leukocytes from SWB were significantly less resistant to increments of shear rate than leukocytes from venous blood (P < 0.01). Conclusions:Despite up-regulated CD11b, integrin-mediated adhesion is markedly impaired in salvaged blood. Therefore, the effect of blood salvage cannot be predicted from cell surface expression but rather from functional assays. The former hypothesis, that leukocytes from SWB aggravate leukocyte-mediated tissue injury by increased adhesion, may not be as great a concern as previously suggested.
A Test for Speculative Bubbles in the Sterling-Dollar Exchange Rate: 1981-84

The U.S. dollar price of the U.K. pound sterling is tested for a speculative bubble, defined as a period with a nonzero median in excessreturns. A nonparametric procedure is developed, which controls for data mining over the period of flexible exchange rates, and finds a negative bubble in the excess return to holding sterling rather than dollar assets during the period 1981-84. Possible interpretations arebootstrap equilibria (rational bubbles), nonsym-metric fundamentals, and nonrational expectations. Copyright 1986 by American Economic Association.
Lactate dehydrogenase in Toxoplasma gondii controls virulence, bradyzoite differentiation, and chronic infection

In the asexual stages, Toxoplasma gondii stage converts between acute phase rapidly replicating tachyzoites and chronic phase slowly dividing bradyzoites. Correspondingly, T. gondii differentially expresses two distinct genes and isoforms of the lactate dehydrogenase enzyme, expressing LDH1 exclusively in the tachyzoite stage and LDH2 preferentially in the bradyzoite stage. LDH catalyzes the interconversion of pyruvate and lactate in anaerobic growth conditions and is utilized for energy supply, however, the precise role of LDH1 and LDH2 in parasite biology in the asexual stages is still unclear. Here, we investigated the biological role of LDH1 and LDH2 in the asexual stages, and the vaccine strain potential of deletion mutants lacking LDH1, LDH2, or both genes (Δldh1, Δldh2 and Δldh1/2). Deletion of LDH1 reduced acute parasite virulence, impaired bradyzoite differentiation in vitro, and markedly reduced chronic stage cyst burdens in vivo. In contrast, deletion of LDH2 impaired chronic stage cyst burdens without affecting virulence or bradyzoite differentiation. Deletion of both LDH1 and LDH2 induced a more severe defect in chronic stage cyst burdens. These LDH mutant phenotypes were not associated with any growth defect. Vaccination of mice with a low dose of mutants deleted for LDH elicited effective protective immunity to lethal challenge infection, demonstrating the vaccine potential of LDH deletion mutants. These results suggest that lactate dehydrogenase in T. gondii controls virulence, bradyzoite differentiation, and chronic infection and reveals the potential of LDH mutants as vaccine strains.
Inferring Logit Models from Empirical Margins Using Proxy Data

We examine several approaches for inferring logit models from empirical margins of predictor covariates and conditional margins containing the means of a binary response for each covariate margin. One method is to fit proxy data to the conditional response using the beta distribution, a process we call “margin analysis. ” Proxy data can obtained using three approaches: (1) implementing the iterative proportional fitting (IPF) procedure on the margin totals, (2) sampling from a larger relevant data source such as the census, and (3) enumerating, or sampling from, the combinatoric space of all possible tables constrained by the margins. The first procedure is a well-studied approach for estimating contingency tables from margins, but it does not necessarily maintain the associations between the covariates unless seeded with an initial table containing those associations. In the second approach, which is appropriate for analyzing sociodemographic covariates, we can use a large census sample adjusting for sampling biases observed in the empirical margins. However, the appropriateness of using a census proxy depends substantially on how similar the sampling pools are. Our third approach entails exploring the combinatoric space of all contingency tables constrained by the margins while considering the associations among the covariates. We aggregate the logit models estimated from each table in that space into a single model. This approach is more robust than the first two as it considers multiple proxies. While the estimated logit models from each approach are generally similar to one another, for the low-dimensional tables we explore in this paper, the combinatoric approach incurs wider standard errors, which renders potentially significant coefficients insignificant. Finally, we suggest weighting the combinatoric models with evidence-relevant probabilities obtained using the multivariate Pólya distribution.
1 . 1 Earlier Results on Implementing the VCG Outcome

We design a simple ascending Vickrey auction for the combinatorial allocation problem. We make use of a concept called universal competitive equilibrium (UCE) price to design our auction. Our auction searches for a UCE price, which (along with an efficient allocation) provides enough information to compute the Vickrey payments of buyers. Our auction maintains non-linear and non-anonymous prices. At every iteration, we identify the set of “unsatisfied” buyers in either the main economy or in one of the “marginal” economies and increase prices of the bundles demanded by these buyers. The auction terminates at a UCE price when there are no unsatisfied buyers in either the main economy or in any of the marginal economies. When buyers are substitutes, considering unsatisfied buyers from the main economy alone terminates the auction at a UCE price. Truthful bidding is an ex post Nash equilibrium for buyers in our auction. In a variant of this auction, we introduce dynamic price discrimination, thus maintaining anonymous prices in the auction as long as possible. This becomes a true generalization of the English auction to the combinatorial allocation problem.
Giant sacral schwannoma: A report of six cases

Abstract Sacral and presacral schwannomas are often found incidentally, because they present with vague symptoms or symptomless. Schwannoma occurring in this area occasionally presents with enormous dimensions, known as a giant schwannoma. The tumor removal is a surgical challenge due to the difficult approach and abundant vascularity. The aim of this study is to review cases of giant sacral schwannomas focusing the surgical management and outcome. Six patients with sacral and presacral schwannoma were treated surgically. The patients included two males and four females, and the mean age was 47.8 years. All patients experienced pain at the time of presentation. The tumors were classified as intraosseous type in one case, dumb-bell type in four cases, and retroperitoneal type in one case. The tumors were removed with a piecemeal subtotal excision in three patients, a partial excision in two patients, and enucleation in one patient. The surgeries were performed by the combination of an anterior and posterior approach in three patients, a posterior approach in two patients, and an anterior approach in one patient. The mean surgical time was 7.8 hrs, and the mean blood loss was 2572 g. The tumor recurred in one patient after the partial excision and was removed completely in a second surgery. No patient, including the patient who underwent the second surgery, presented with pain and obvious neurological deficit at the final follow-up. The surgical treatment of the giant sacral schwannoma with a piecemeal subtotal excision can achieve a good outcome, avoiding unnecessary neurological deficit.
Effects of Online Reading on Popular Science Comprehension

The present study examines the effects of print and online presentations of a multiple document report on reader’s comprehension, perception of cognitive load, satisfaction, and attention. We hypothesized that users of online media would show poorer results compared with print users. An experimental protocol was used to assess readers’performance using print and online versions of a popular science magazine report. Hypertext led to higher perceived cognitive load and poorer comprehension of the complementary documents. The results suggest that presenting graphics in long hypertexts increases effort and reduces text legibility. The present data offer support for theories of disorientation and cognitive load in hypermedia learning.
Evaluation of Goodness-ofFit Indices for Structural Equation Models

Discusses how current goodness-of-fit indices fail to assess parsimony and hence disconfirmability of a model and are insensitive to misspecifications of causal relations (a) among latent variables when measurement model with many indicators is correct and (b) when causal relations corresponding to free parameters expected to be nonzero turn out to be zero or near zero. A discussion of philosophy of parsimony elucidates relations of parsimony to parameter estimation, disconfirmability, and goodness of fit. AGFI in LISREL is rejected. A method of adjusting goodness-of-fit indices by a parsimony ratio is described. Also discusses less biased estimates of goodness of fit and a relative normedfit index for testing fit of structural model exclusive of the measurement model.
Visual-Gustatory Interaction: Orbitofrontal and Insular Cortices Mediate the Effect of High-Calorie Visual Food Cues on Taste Pleasantness

Vision provides a primary sensory input for food perception. It raises expectations on taste and nutritional value and drives acceptance or rejection. So far, the impact of visual food cues varying in energy content on subsequent taste integration remains unexplored. Using electrical neuroimaging, we assessed whether high- and low-calorie food cues differentially influence the brain processing and perception of a subsequent neutral electric taste. When viewing high-calorie food images, participants reported the subsequent taste to be more pleasant than when low-calorie food images preceded the identical taste. Moreover, the taste-evoked neural activity was stronger in the bilateral insula and the adjacent frontal operculum (FOP) within 100 ms after taste onset when preceded by high- versus low-calorie cues. A similar pattern evolved in the anterior cingulate (ACC) and medial orbitofrontal cortex (OFC) around 180 ms, as well as, in the right insula, around 360 ms. The activation differences in the OFC correlated positively with changes in taste pleasantness, a finding that is an accord with the role of the OFC in the hedonic evaluation of taste. Later activation differences in the right insula likely indicate revaluation of interoceptive taste awareness. Our findings reveal previously unknown mechanisms of cross-modal, visual-gustatory, sensory interactions underlying food evaluation.
Coenzyme Q10 Levels Are Decreased in the Cerebellum of Multiple-System Atrophy Patients

Background The objective of this study was to evaluate whether the levels of coenzyme Q10 (CoQ10) in brain tissue of multiple system atrophy (MSA) patients differ from those in elderly controls and in patients with other neurodegenerative diseases. Methods Flash frozen brain tissue of a series of 20 pathologically confirmed MSA patients [9 olivopontocerebellar atrophy (OPCA) type, 6 striatonigral degeneration (SND) type, and 5 mixed type] was used for this study. Elderly controls (n = 37) as well as idiopathic Parkinson's disease (n = 7), dementia with Lewy bodies (n = 20), corticobasal degeneration (n = 15) and cerebellar ataxia (n = 18) patients were used as comparison groups. CoQ10 was measured in cerebellar and frontal cortex tissue by high performance liquid chromatography. Results We detected a statistically significant decrease (by 3–5%) in the level of CoQ10 in the cerebellum of MSA cases (P = 0.001), specifically in OPCA (P = 0.001) and mixed cases (P = 0.005), when compared to controls as well as to other neurodegenerative diseases [dementia with Lewy bodies (P<0.001), idiopathic Parkinson's disease (P<0.001), corticobasal degeneration (P<0.001), and cerebellar ataxia (P = 0.001)]. Conclusion Our results suggest that a perturbation in the CoQ10 biosynthetic pathway is associated with the pathogenesis of MSA but the mechanism behind this finding remains to be elucidated.
Functional variable method and its applications for finding exact solutions of nonlinear PDEs in mathematical physics

The functional variable method is a powerful mathematical tool for obtaining exact solutions of nonlinear evolution equations in mathematical physics. In this paper, the functional variable method is used to establish exact solutions of the (2+1)-dimensional Kadomtsov-Petviashivilli-Benjamin-Bona-Mahony (KP-BBM) equation, the (2+1)-dimensional Konopelchenko-Dubrovsky equation, the (3+1)-dimensional Burgers equation and the (3+1)- dimensional Jimbo-Miwa equation. The exact solutions of these four nonlinear equations including solitary wave solutions and periodic wave solutions are obtained. It is shown that the proposed method is effective and can be applied to many other nonlinear evolution equations. Comparison between our results obtained in this paper and the well-known results obtained by different authors using different methods are presented. Key words: Functional variable method, nonlinear evolution equations, exact solutions, solitary wave solutions, Periodic wave solutions.
The Role of Tourism and Recreation in the Spread of Non-Native Species: A Systematic Review and Meta-Analysis

Managing the pathways by which non-native species are introduced and spread is considered the most effective way of preventing species invasions. Tourism and outdoor recreation involve the frequent congregation of people, vehicles and vessels from geographically diverse areas. They are therefore perceived to be major pathways for the movement of non-native species, and ones that will become increasingly important with the continued growth of these sectors. However, a global assessment of the relationship between tourism activities and the introduction of non-native species–particularly in freshwater and marine environments–is lacking. We conducted a systematic review and meta-analysis to determine the impact of tourism and outdoor recreation on non-native species in terrestrial, marine and freshwater environments. Our results provide quantitative evidence that the abundance and richness of non-native species are significantly higher in sites where tourist activities take place than in control sites. The pattern was consistent across terrestrial, freshwater and marine environments; across a variety of vectors (e.g. horses, hikers, yachts); and across a range of taxonomic groups. These results highlight the need for widespread biosecurity interventions to prevent the inadvertent introduction of invasive non-native species (INNS) as the tourism and outdoor recreation sectors grow.
‘That Tiny, Stratospheric Apex That Owns Most of the World’– Exploring Geographies of the Super‐Rich

This paper exhorts geographers to give critical attention to the super-rich, defined as individuals with investable assets in excess of $1 million. The super-rich currently number almost 11 million globally (2011) and have collective wealth in excess of $42 trillion. We argue that as a result of our discipline's typical, and not unjustifiable, focus on the poor and middle class, and our neglect of the super-rich, geographers may both be overlooking potentially valuable insights to the institutions, practices, and cultural values of our society and gaining only a partial view of global capitalism. We point to prospectively useful work in areas that embrace relationships between the super-rich, place, and mobility; links between wealth and (geo)politics; new philanthropy; and the social and environmental consequences of ‘luxury fever’. We also speculate as to some of the reasons for geographers’ apparent reluctance to engage with the super-rich, responding to some of the critical methodological challenges associated with such work.
How Well Do We Know Our Own Conscious Experience? The Case of Visual Imagery

Philosophers tend to assume that we have excellent knowledge of our own current conscious experience or ‘phenomenology’. I argue that our knowledge of one aspect of our experience, the experience of visual imagery, is actually rather poor. Precedent for this position is found among the introspective psychologists of the late nineteenth and early twentieth centuries. Two main arguments are advanced toward the conclusion that our knowledge of our own imagery is poor. First, the reader is asked to form a visual image, and it is expected that answering questions about certain basic features of that experience will be difficult. If so, it seems reasonable to suppose that people could be mistaken about those basic features of their own imagery. Second, it is observed that although people give widely variable reports about their own experiences of visual imagery, differences in report do not systematically correlate with differences on tests of skills that psychologists have often supposed to require visual imagery, such as mental rotation, visual creativity, and visual memory.