Miracle-dz/UniFAR-FTUs huggingface dataset:
Hard Evidence and Mechanism Design

In this short paper, we show how hard evidence can be incorporated into the mechanism-design framework. We model the parties' inalienable decisions (evidence production) as distinct from an arbitrarily-designed message form. A mechanism specifies the message form and how the public decision is a function of messages and evidence. Our work is thus along the lines of Myerson (1982, 1991), whose mechanism-design analysis nicely distinguishes between inalienable private and public decisions.
Multiscale modeling of structural dynamics underlying force generation and product release in actomyosin complex

To decrypt the mechanistic basis of myosin motor function, it is essential to probe the conformational changes in actomyosin with high spatial and temporal resolutions. In a computational effort to meet this challenge, we have performed a multiscale modeling of the allosteric couplings and transition pathway of actomyosin complex by combining coarse‐grained modeling of the entire complex with all‐atom molecular dynamics simulations of the active site. Our modeling of allosteric couplings at the pre‐powerstroke state has pinpointed key actin‐activated couplings to distant myosin parts which are critical to force generation and the sequential release of phosphate and ADP. At the post‐powerstroke state, we have identified isoform‐dependent couplings which underlie the reciprocal coupling between actin binding and nucleotide binding in fast Myosin II, and load‐dependent ADP release in Myosin V. Our modeling of transition pathway during powerstroke has outlined a clear sequence of structural events triggered by actin binding, which lead to subsequent force generation, twisting of central β‐sheet, and the sequential release of phosphate and ADP. Finally we have performed atomistic simulations of active‐site dynamics based on an on‐path “transition‐state” myosin conformation, which has revealed significantly weakened coordination of phosphate by Switch II, and a disrupted key salt bridge between Switch I and II. Meanwhile, the coordination of MgADP by Switch I and P loop is less perturbed. As a result, the phosphate can be released prior to MgADP. This study has shed new lights on the controversy over the structural mechanism of actin‐activated phosphate release and force generation in myosin motor. Proteins 2010. © 2009 Wiley‐Liss, Inc.
Analyzing the complementarity of web infrastructure and eInnovation for business value generation

Purpose – In recent years, there has been much debate about the value generated by the firms’ investments in information technology (IT). Although literature suggests that technology itself will rarely create superiority, web infrastructure can be critical for knowledge sharing and the formation of virtual teams to execute innovation processes which, in turn, may enhance e-innovation and business value. Building on these antecedents, the purpose of this paper is to explore whether and how web infrastructure and e-innovation can create business value by complementing each other. Design/methodology/approach – Based on the resource-based view (RBV) of the firm this paper develops a conceptual model to assess the effects of web infrastructure and e-innovation on business value as well as the complementarity between these resources. To test the associated hypotheses, a regression model was estimated and tested on a large sample of Spanish firms from different industries. Findings – The results show that web in.
Efficient Broadcasting in VANETs Using Dynamic Backbone and Network Coding

Multihop data dissemination in vehicular ad hoc networks (VANETs) is very important for the realization of collision avoidance systems and many other interesting applications. However, designing an efficient data dissemination protocol for VANETs has been a challenging issue due to vehicle movements, limited wireless resources, and the lossy characteristics of wireless communication. In this paper, we propose a protocol that can provide a lightweight and reliable solution for data dissemination in VANETs. The protocol employs dynamically generated backbone vehicles to disseminate broadcast packets to reduce the MAC-layer contention time at each node while maintaining a high packet dissemination ratio by taking into account vehicle movement dynamics and the link quality between vehicles for the backbone selection. The protocol also uses network coding to reduce the protocol overhead and to improve the packet reception probability as compared with conventional approaches. We use theoretical analysis and computer simulations to show the advantage of the proposed protocol over other existing alternatives.
Training of the executive component of working memory: subcortical areas mediate transfer effects.

PURPOSE Several recent studies show that training can improve working memory (WM) performance. In this review, many issues related to WM training, such as neural basis, transfer effects, and age-related changes are addressed. METHOD We focus on our own studies investigating training on tasks taxing the executive updating function and discuss our findings in relation to results from other studies investigating training of the executive component of WM. RESULTS The review confirms positive behavioral effects of training on working memory. The most common neural pattern following training is fronto-parietal activity decreases. Increases in sub-cortical areas are also frequently reported after training, and we suggest that such increases indicate changes in the underlying skill following training. Transfer effects are in general difficult to demonstrate. Some studies show that older adults increase their performance after WM training. However, transfer effects are small or nonexistent in old age. CONCLUSIONS The main finding in this review is that sub-cortical areas seem to have a critical role in mediating transfer effects to untrained tasks after at least some forms of working memory training (such as updating).
Family limitation and the fertility transition: Evidence from the age patterns of fertility in Europe and Asia.

Summary The age patterns of marital fertility levels and decline in modern Asia and historical Europe are analysed in order to answer two questions: (1) How closely do the age patterns of marital fertility in both areas prior to a systematic fertility decline conform to the age pattern of natural fertility? (2) How similar are the age patterns of the fertility transition experienced in Europe in the past, and the age pattern of fertility decline now under way in a number of Asian populations? The answers have important implications for our understanding of the fertility transition. They suggest that modern family limitation (i.e. parity-specific fertility control) was largely absent prior to a secular decline in marital fertility in both Europe and Asia. Furthermore, the evidence indicates that once the practice of family limitation starts to spread among the broader strata of the population, it seems almost inevitably to increase until it becomes a common behavioural norm. In this respect, the modern fertility transition appears to result from the spread of innovative behaviour and cannot be viewed simply as an adjustment to new socio-economic circumstances based on previously established behavioural mechanisms.
Outage Constrained Robust Transmit Optimization for Multiuser MISO Downlinks: Tractable Approximations by Conic Optimization

In this paper, we study a probabilistically robust transmit optimization problem under imperfect channel state information (CSI) at the transmitter and under the multiuser multiple-input single-output (MISO) downlink scenario. The main issue is to keep the probability of each user's achievable rate outage as caused by CSI uncertainties below a given threshold. As is well known, such rate outage constraints present a significant analytical and computational challenge. Indeed, they do not admit simple closed-form expressions and are unlikely to be efficiently computable in general. Assuming Gaussian CSI uncertainties, we first review a traditional robust optimization-based method for approximating the rate outage constraints, and then develop two novel approximation methods using probabilistic techniques. Interestingly, these three methods can be viewed as implementing different tractable analytic upper bounds on the tail probability of a complex Gaussian quadratic form, and they provide convex restrictions, or safe tractable approximations, of the original rate outage constraints. In particular, a feasible solution from any one of these methods will automatically satisfy the rate outage constraints, and all three methods involve convex conic programs that can be solved efficiently using off-the-shelf solvers. We then proceed to study the performance-complexity tradeoffs of these methods through computational complexity and comparative approximation performance analyses. Finally, simulation results are provided to benchmark the three convex restriction methods against the state of the art in the literature. The results show that all three methods offer significantly improved solution quality and much lower complexity.
The Effectiveness of Diaphragmatic Breathing Relaxation Training for Reducing Anxiety

PURPOSE To evaluate the effectiveness on reducing anxiety of a diaphragmatic breathing relaxation (DBR) training program. DESIGN AND METHODS This experimental, pre-test-post-test randomized controlled trial with repeated measures collected data using the Beck Anxiety Inventory and biofeedback tests for skin conductivity, peripheral blood flow, heart rate, and breathing rate. FINDINGS The experimental group achieved significant reductions in Beck Anxiety Inventory scores (p < .05), peripheral temperature (p = .026), heart rate (p = .005), and breathing rate (p = .004) over the 8-week training period. The experimental group further achieved a significant reduction in breathing rate (p < .001). PRACTICE IMPLICATIONS The findings provide guidance for providing quality care that effectively reduces the anxiety level of care recipients in clinical and community settings.
Attitudes and Behaviors of Practicing Community Pharmacists Towards Patient Counselling

The present study was conducted to assess the attitudes and behaviors of practicing community pharmacists towards patient counselling and use of patient information leaflets in the state of Karnataka. Convenient sampling method was adopted to collect the responses with the help of self-completion questionnaires. A total of 258 practicing community pharmacists in the age group of 22–60 y of both gender with practicing experience of 2-30 y participated in the study. Majority of respondents (80%) agreed that, patient counselling is their professional obligation. About 17% of the respondents mentioned that, they try to give basic information regarding drug usage to the patient. The reasons stated by the pharmacists to provide patient counselling were, professional satisfaction (43%), patients go with satisfaction (32%), observed increase in sales (8%), and also improved patient compliance (7.5%). The major barriers for offering patient counselling were mentioned as pharmacists' inadequate knowledge and confidence (78%), doctor dispensing (72%), no professional fee (56%), poor response from patients (82%), inadequate continuous professional development programs (75%). Many respondents agreed that, patient information leaflets certainly help in counselling but available information leaflets are company generated and prescriber focused. Many respondents found the present continuing professional development module was useful and are interested in weekend workshops to update their professional knowledge (83%). Restrictions on doctor dispensing, legalization of patient counselling, regular continuing professional development programs are the factors observed to motivate the pharmacists to offer patient counselling.
Improving the specificity of 16S rDNA‐based polymerase chain reaction for detecting Borrelia burgdorferi sensu lato‐causative agents of human Lyme disease

Aims: 16S rDNA sequences of Borrelia burgdorferi sensu lato were aligned with the 16S rDNA sequences of Borrelia hermsii, Borrelia turicatae, and Borrelia lonestari in order to identify primers that might be used to more specifically identify agents of human Lyme disease in ticks in human skin samples.
Is it correct to always consider weight-bearing asymmetrically distributed in individuals with hemiparesis?

Injuries may cause unilateral deterioration of brain areas related to postural control resulting in lateralized motor disability with abnormal asymmetry in weight-bearing distribution. Although overloading toward the nonaffected limb has been described as the preferred posture among individuals with hemiparesis, characterization of the weight-bearing asymmetry is poorly and indirectly described. Therefore, this study aimed to describe weight-bearing distribution during upright stance, establishing criteria to consider asymmetry in hemiparesis when analyzed within the limits defined by controls matched by age and gender. Forty subjects with (n = 20) or without hemiparesis (n = 20) were included in procedures to record weight-bearing values between hemibodies, and these values were used to calculate a symmetry ratio. Control presented 95% confidence interval (CI) of the mean for symmetry ratio ranging from 0.888 to 1.072, defining limits to symmetry. Four subjects with hemiparesis (20%) had symmetry ratios inside limits defined by controls (i.e., weight-bearing symmetrically distributed), and 11 (55%) subjects without hemiparesis showed symmetry ratios outside the limits, suggesting asymmetrical weight-bearing distribution. It was concluded that asymmetry, when present in a control group, was more frequently overloading nonpredominantly used hemibody (nondominant side), differing from a hemiparesis group commonly forced to assume the nonaffected side as the predominantly used hemibody and where the overload was observed.
Environmental and Individual Factors Associated with Nail Fluoride Concentration

Nails have been suggested as suitable biomarkers of exposure to F, with the advantage of being easily obtained. The effect of water F concentration, age, gender, nail growth rate and geographical area on the F concentration in the fingernail and toenail clippings were evaluated. Volunteers (n = 300) aged 3–7, 14–20, 30–40 and 50–60 years from five Brazilian communities (A–E) participated. Drinking water and nail samples were collected and F concentration was analyzed with the electrode. A reference mark was made on each nail and growth rates were calculated. Data were analyzed by ANOVA and linear regression (α = 0.05). Mean water F concentrations (± SE, mg/l) were 0.09 ± 0.01, 0.15 ± 0.01, 0.66 ± 0.01, 0.72 ± 0.02, and 1.68 ± 0.08 for A–E, respectively. Mean F concentrations (± SE, mg/kg) ranged between 1.38 ± 0.14 (A, 50–60 years) and 10.20 ± 2.35 (D, 50–60 years) for fingernails, and between 0.92 ± 0.08 (A, 14–20 years) and 7.35 ± 0.80 (E, 50–60 years) for toenails. Among the tested factors, geographical area and water F concentration exerted the most influence on finger- and toenail F concentrations. Subjects of older age groups (30–40 and 50–60 years) from D and E showed higher nail F concentrations than the others. Females presented higher nail F concentration than males. Water F concentration, age, gender and geographical area influenced the F concentration of finger- and toenails, and hence should be taken into account when using this biomarker of exposure to predict risk for dental fluorosis.
A Bivalent Polyploid Model for Mapping Quantitative Trait Loci in Outcrossing Tetraploids

Two major aspects have made the genetic and genomic study of polyploids extremely difficult. First, increased allelic or nonallelic combinations due to multiple alleles result in complex gene actions and interactions for quantitative trait loci (QTL) in polyploids. Second, meiotic configurations in polyploids undergo a complex biological process including either bivalent or multivalent formation, or both. For bivalent polyploids, different degrees of preferential chromosome pairings may occur during meiosis. In this article, we develop a maximum-likelihood-based model for mapping QTL in tetraploids by considering the quantitative inheritance and meiotic mechanism of bivalent polyploids. This bivalent polyploid model is implemented with the EM algorithm to simultaneously estimate QTL position, QTL effects, and QTL-marker linkage phases by incorporating the impact of a cytological parameter determining bivalent chromosome pairings (the preferential pairing factor). Simulation studies are performed to investigate the performance and robustness of our statistical method for parameter estimation. The implication and extension of the bivalent polyploid model are discussed.
Effect of sorafenib on cisplatin-based chemoradiation in head and neck cancer cells

Despite aggressive chemoradiation (CRT) protocols in the treatment of patients with head and neck squamous cell carcinomas (HNSCC), the outcome is still unfavorable. To improve therapy efficacy we had already successfully tested the multikinase inhibitor sorafenib in combination with irradiation (IR) in previous studies on HNSCC cell lines. In this study we investigated its effect on combined CRT treatment using cisplatin.Radio- and chemosensitivity with and without sorafenib was measured in four HNSCC cell lines and normal fibroblasts (NF) by colony formation assay. Apoptosis and cell cycle analysis were performed by flow cytometry. In HNSCC cells, sorafenib enhanced the antiproliferative effect of cisplatin without affecting apoptosis induction and with only minor effects on cell inactivation. Sorafenib added prior to irradiation enhanced cellular radiosensitivity in three of the tested HNSCC cell lines and caused massive overall cell inactivation when combined with CRT. In contrast, sorafenib did not radiosensitize NF and reduced cisplatin-induced cell inactivation. Cell inactivation by IR and cisplatin is further increased by the addition of sorafenib in HNSCC, but not in NF cells. Therefore, sorafenib is a promising candidate to improve therapy efficacy for HNSCC.
Mean Platelet Volume in Relation to Carotid Atherosclerosis in Normotensive, Euglycemic, and Normolipidemic Chinese Middle-Aged and Elderly Adults

We investigated whether mean platelet volume (MPV) is independently associated with the carotid intima–media thickness (cIMT) in normotensive, euglycemic, and normolipidemic middle-aged and elderly adults. A total of 256 males and 398 females were enrolled from the Changfeng Study. Compared to male patients with MPV in the first quintile, male patients with MPV in the fifth quintile had greater cIMTs and higher prevalence of carotid plaque. After adjusting for conventional cardiovascular disease risk factors, male participants with MPV in the fifth quintile had a 1.669-fold increased risk of carotid plaques relative to those in the lowest quintiles. In female patients, the cIMTs and prevalence of carotid plaque were not significantly different among the groups. These results suggest that MPV is independently associated with carotid atherosclerosis in normotensive, euglycemic, and normolipidemic males. The MPV could be an easily measured marker of atherosclerosis for males.
Quantum support vector machine for big feature and big data classification

Supervised machine learning is the classification of new data based on already classified training examples. In this work, we show that the support vector machine, an optimized binary classifier, can be implemented on a quantum computer, with complexity logarithmic in the size of the vectors and the number of training examples. In cases where classical sampling algorithms require polynomial time, an exponential speedup is obtained. At the core of this quantum big data algorithm is a nonsparse matrix exponentiation technique for efficiently performing a matrix inversion of the training data inner-product (kernel) matrix.
Anti-diuresis in the management of daytime urinary incontinence

Urinary incontinence and lower urinary tract dysfunction, whilst not life threatening conditions, remain an important cause of morbidity in women and are responsible for significant impairment of quality of life. Drug therapy is often used to treat women who complain of urgency and urge incontinence and has an emerging role in the management of stress urinary incontinence. However, bothersome side effects are known to affect compliance and therefore compromise efficacy, making longterm drug therapy unpopular. The principle aim of this thesis is to assess the role of antidiuresis in women complaining of daytime urinary incontinence and also to examine its role as a ‘designer therapy’ which women can choose to use as, or when, required. In addition both the patients’ and clinicians’ attitudes towards treatment have been studied to clarify the meaning of ‘cure’, and to determine treatment acceptability, overall outcome and patient satisfaction. In the first study the patients’ concept of cure is explored as well as their expectations regarding treatment and outcome. The second study examines cure from the clinician’s perspective in addition to reviewing outcome measures in the clinical and research settings. Finally in the third study the use of desmopressin in women complaining of daytime urinary incontinence is reported.
Ieee Projects 100% Working Code + Documentation+ Explaination – Best Price Secure Deduplication with Efficient and Reliable Convergent Key Management

Data Deduplication is a technique for eliminating duplicate copies of data, and has been widely used in cloud storage to reduce storage space and upload bandwidth. Promising as it is, an arising challenge is to perform secure Deduplication in cloud Storage. Although convergent encryption has been extensively adopted for secure Deduplication, a critical issue of making convergent encryption practical is to efficiently and reliably manage a huge number of convergent keys. The first attempt to formally address the problem of achieving efficient and reliable key management in secure Deduplication. We first introduce a baseline approach in which each user holds an independent master key for encrypting the convergent keys and outsourcing them to the cloud. However, such a baseline key management scheme generates an enormous number of keys with the increasing number of users and requires users to dedicatedly protect the master keys. To this end, we propose Dekey, a new construction in which users do not need to manage any keys on their own but instead securely distribute the convergent key shares across multiple servers. Security analysis demonstrates that Dekey is secure in terms of the definitions specified in the proposed security model. Convergent encryption, also known as content hash keying, is a cryptosystem that produces identical cipher text from identical plaintext files. This has applications in cloud
- Hydroxyprogesterone : Origin , biosynthesis and receptor interaction arl -

The metabolism of progesterone (PROG) by cytochrome P450 17 -hydroxylase/17,20-lyase (CYP17A1) results in the formation of both 17 -hydroxyprogesterone (17-OHPROG) and 16 -hydroxyprogesterone (16-OHPROG) in humans. Unlike 17-OHPROG, 16-OHPROG is not metabolised further in steroidogenic tissue. While this metabolite can be readily detected in serum and urine, its physiological role remains unclear. This paper reviews the production of 16-OHPROG by human CYP17A1 by providing insight into the catalysis of PROG by CYP17A1 and highlights the role of Ala105 in the 16 -hydroxylation reaction. eywords: 6 -Hydroxyprogesterone
A modular module system

A simple implementation of an SML-like module system is presented as a module parameterized by a base language and its type-checker. This implementation is useful both as a detailed tutorial on the Harper–Lillibridge–Leroy module system and its implementation, and as a constructive demonstration of the applicability of that module system to a wide range of programming languages.