Miracle-dz/UniFAR-FTUs huggingface dataset:
CORMAN: A Novel Cooperative Opportunistic Routing Scheme in Mobile Ad Hoc Networks

The link quality variation of wireless channels has been a challenging issue in data communications until recent explicit exploration in utilizing this characteristic. The same broadcast transmission may be perceived significantly differently, and usually independently, by receivers at different geographic locations. Furthermore, even the same stationary receiver may experience drastic link quality fluctuation over time. The combination of link-quality variation with the broadcasting nature of wireless channels has revealed a direction in the research of wireless networking, namely, cooperative communication. Research on cooperative communication started to attract interests in the community at the physical layer but more recently its importance and usability have also been realized at upper layers of the network protocol stack. In this article, we tackle the problem of opportunistic data transfer in mobile ad hoc networks. Our solution is called Cooperative Opportunistic Routing in Mobile Ad hoc Networks (CORMAN). It is a pure network layer scheme that can be built atop off-the-shelf wireless networking equipment. Nodes in the network use a lightweight proactive source routing protocol to determine a list of intermediate nodes that the data packets should follow en route to the destination. Here, when a data packet is broadcast by an upstream node and has happened to be received by a downstream node further along the route, it continues its way from there and thus will arrive at the destination node sooner. This is achieved through cooperative data communication at the link and network layers. This work is a powerful extension to the pioneering work of ExOR. We test CORMAN and compare it to AODV, and observe significant performance improvement in varying mobile settings.
Glycolysis in Panc-1 human pancreatic cancer cells is inhibited by everolimus

The aim of this study was to evaluate the effects and molecular mechanisms of everolimus on Panc-1 human pancreatic cancer cells. Panc-1 human pancreatic cancer cells were treated with everolimus (10 μg/ml) at selected time points (6, 12 and 24 h). Cell proliferation and apoptosis were evaluated by MTT and flow cytometric analyses. The glycolytic activity was determined by measuring the activity of the key enzyme lactate dehydrogenase (LDH) and lactate production. The activity of mammalian target of rapamycin (mTOR) signaling was measured by western blotting. The expression of genes, including hexokinase 2 (HK2) and microRNA-143 (miR-143), was evaluated by real-time polymerase chain reaction (PCR). The administration of everolimus time-dependently inhibited proliferation and glycolysis and induced apoptosis in the Panc-1 human pancreatic cancer cells. As the time of treatment with everolimus increased, the mTOR signaling activity decreased, indicated by lower phosphorylation levels of S6 kinase; however, the phosphorylation levels of mTOR barely changed. Moreover, our data showed an everolimus-induced increase in miR-143 and decrease in HK2 in Panc-1 cells in a time-dependent manner. In conclusion, the current study indicates a novel role of everolimus in its antitumor effect as an inhibitor of glycolysis in Panc-1 human pancreatic cancer cells. Furthermore, our data highlights the significance of exploring the mechanisms of everolimus and miR-143 in malignant tumors.
A comparison of normative and interactional explanations of group decision‐making: Social decision schemes versus valence distributions

Research on group decision‐making in speech communication has assumed interaction processes are important determinants of group decisions. However, major psychological theories of group decision‐making challenge this assumption. This study tested a prominent social psychological theory, Davis's Social Decision Scheme Model, against an interaction‐based model of group decision‐making, the Valence Distribution Model recently developed by McPhee, Poole, and Seibold. The theoretical rationale for the comparison was provided by the theory of structuration, which predicted the Valence Distribution Model would mediate the effect of Social Decision Schemes on group decisions. Results substantially supported this prediction.
Need Structure, Leisure Motivation, and Psychosocial Adjustment Among Young Offenders and High School Students

Abstract The Personality Research Form-E (PRF-E; 20 need structure scales), the Holden Psychological Screening Inventory (HPSI; 3 psychosocial adjustment scales), and the Leisure Motivation Scale (LMS; 4 leisure motivation scales) were administered to 60 young offenders and 50 high school students. Significant between sample differences in means resulted for the HPSI Psychiatric, Social, and Depression Symptomatology scales; the PRF-E Affiliation, Aggression, Autonomy, and Harm Avoidance content scales; and the LMS Social scale. Statistically significant correlations resulted between the LMS and 19 of the 20 PRF-E content scales as well as the HPSI Depression and Social Symptomatology scales. It is concluded that young offenders, as compared to high school students, are significantly less well adjusted and have different leisure motivations and personality needs. It is likely that need structure impacts directly on psychosocial adjustment as well as indirectly through leisure motivation.
Principals Judge Teachers by Their Teaching

This quantitative study investigated the relationship between teacher dispositions, subject content knowledge, pedagogical content knowledge, and reasons that school principals recommend non-renewal of probationary teachers' contracts. Principals in the Southeastern Unites States completed an e-mailed survey. Two nonparametric tests, Kruskal-Wallis and Mann Whitney U, were used to statistically analyze group responses. Principals reported that they observed most a lack of pedagogical content knowledge from ineffective teachers and they prioritized the importance of instructional skills in deciding whether to non-renew a teacher contract. Principals identified teacher integrity, dependability, and honesty as important dispositions. The studies' findings are important for universities that prepare preservice teachers and also for the planning of professional development initiatives. The study findings suggest that principals tend to view dispositions as personality characteristics rather than as teacher competencies and that teacher expertise in both subject content and pedagogy must be woven together.
Peripheral Persuasion and Brand Choice

Although the impact of peripheral advertising cues on postcommunication attitudes has received considerable attention in the research literature, less consideration has been given to whether such persuasion affects behavior. This research examines the potential for peripheral persuasion to influence brand choice as a function of the degree of differentiation among choice alternatives. The results from three experiments show that peripheral advertising cues can affect brand choice but that the extent of this influence depends on the particular brand-relevant information available at the time of choice. These findings substantiate the usefulness of peripheral persuasion tactics for modifying consumer choice. Copyright 1992 by the University of Chicago.
Overlapping Roles for Homeodomain-Interacting Protein Kinases Hipk1 and Hipk2 in the Mediation of Cell Growth in Response to Morphogenetic and Genotoxic Signals

ABSTRACT Homeodomain-interacting protein kinase 1 (Hipk1), 2, and 3 genes encode evolutionarily conserved nuclear serine/threonine kinases, which were originally identified as interacting with homeodomain-containing proteins. Hipks have been repeatedly identified as interactors for a vast range of functional proteins, including not only transcriptional regulators and chromatin modifiers but also cytoplasmic signal transducers, transmembrane proteins, and the E2 component of SUMO ligase. Gain-of-function experiments using cultured cells indicate growth regulatory roles for Hipks on receipt of morphogenetic and genotoxic signals. However, Hipk1 and Hipk2 singly deficient mice were grossly normal, and this is expected to be due to a functional redundancy between Hipk1 and Hipk2. Therefore, we addressed the physiological roles of Hipk family proteins by using Hipk1 Hipk2 double mutants. Hipk1 Hipk2 double homozygotes are progressively lost between 9.5 and 12.5 days postcoitus and frequently fail to close the anterior neuropore and exhibit exencephaly. This is most likely due to defective proliferation in the neural fold and underlying paraxial mesoderm, particularly in the ventral region, which may be attributed to decreased responsiveness to Sonic hedgehog signals. The present study indicated the overlapping roles for Hipk1 and Hipk2 in mediating cell proliferation and apoptosis in response to morphogenetic and genotoxic signals during mouse development.
Perceptions of Organisational Subculture and their Significance for Organisational Commitment

This paper investigates the relationship between perceptions of organisational culture, organisational subculture, leadership style, and commitment. The impact of culture and leadership style on commitment has been previously noted, but there is a lack of detail regarding how different types of culture and leadership styles relate to commitment. The paper particularly addresses the notion of organisational subcultures and how the perception of those cultures relates to commitment, subculture being a neglected variable in the commitment literature. These issues were addressed in a survey of 258 nurses drawn from a range of hospital settings and wards within the Sydney metropolitan region. Results indicate that perceived organisational subculture has a strong relationship with commitment. Furthermore, the results identify the relative strength of specific types of leadership style and specific types of subculture with commitment. Both innovative and supportive subcultures have a clear positive relationship, while bureaucratic subcultures have a negative relationship. In terms of leadership style, a consideration style had a stronger relationship with commitment than a structuring style. Regression analysis was used to investigate the possible role of subculture as a mediator for the influence of leadership on commitment. Both direct and indirect effects of leadership on commitment were found. Implications for practice and for further research are discussed.
Interplay between Manganese and Iron in Pneumococcal Pathogenesis: Role of the Orphan Response Regulator RitR

ABSTRACT Streptococcus pneumoniae (the pneumococcus) is a major human pathogen that is carried asymptomatically in the nasopharynx by up to 70% of the human population. Translocation of the bacteria into internal sites can cause a range of diseases, such as pneumonia, otitis media, meningitis, and bacteremia. This transition from nasopharynx to growth at systemic sites means that the pneumococcus needs to adjust to a variety of environmental conditions, including transition metal ion availability. Although it is an important nutrient, iron potentiates oxidative stress, and it is established that in S. pneumoniae, expression of iron transport systems and proteins that protect against oxidative stress are regulated by an orphan response regulator, RitR. In this study, we investigated the effect of iron and manganese ion availability on the growth of a ritR mutant. Deletion of ritR led to impaired growth of bacteria in high-iron medium, but this phenotype could be suppressed with the addition of manganese. Measurement of metal ion accumulation indicated that manganese prevents iron accumulation. Furthermore, the addition of manganese also led to a reduction in the amount of hydrogen peroxide produced by bacterial cells. Studies of virulence in a murine model of infection indicated that RitR was not essential for pneumococcal survival and suggested that derepression of iron uptake systems may enhance the survival of pneumococci in some niches.
What factors determine therapists’ acceptance of new technologies for rehabilitation – a study using the Unified Theory of Acceptance and Use of Technology (UTAUT)

Abstract Purpose: The aim of this study was to examine what factors affect the acceptance behavior and use of new technologies for rehabilitation by therapists at a large rehabilitation hospital in Canada. Method: A self-administrated paper-based survey was created by adapting scales with high levels of internal consistency in prior research using the Unified Theory of Acceptance and Use of Technology (UTAUT). Items were scored on a 7-point Likert scale, ranging from “strongly disagree (1)” to “strongly agree (7)”. The target population was all occupational therapists (OT) and physical therapists (PT) involved with the provision of therapeutic interventions at the hospital. Our research model was tested using partial least squares (PLS) technique. Results: Performance expectancy was the strongest salient construct for behavioral intention to use new technologies in rehabilitation, whereas neither effort expectancy nor social influence were salient constructs for behavioral intention to use new technologies; (4) facilitating condition and behavioral intention to use new technologies were salient constructs for current use of new technologies in rehabilitation, with facilitating condition the strongest salient for current use of new technologies in rehabilitation. Conclusion: In a large rehabilitation hospital where use of new technologies in rehabilitation is not mandatory, performance expectancy, or how the technology can help in therapists’ work, was the most important factor in determining therapists’ acceptance and use of technologies. However, effort expectancy and social influence constructs were not important, i.e. therapists were not influenced by the degree of difficulty or social pressures to use technologies. Behavioral intention and facilitating condition, or institutional support, are related to current use of new technologies in rehabilitation. Implications for Rehabilitation Rehabilitation professionals who are faced with using new technologies are less concerned about effort and social pressures, than they are about what the technologies can do for them or their clients. When it comes to new rehabilitation technologies, actual users express intention. Rehabilitation professionals’ acceptance and adoption of technologies rely on conditions that facilitate their use. These conditions include scheduling, support and a conductive environment.
Lectin-Induced Inhibition of Desensitization of the Kainate Receptor GluR6 Depends on the Activation State and Can Be Mediated by a Single Native or Ectopic N-Linked Carbohydrate Side Chain

The ionotropic glutamate receptor GluR6 exhibits strongly and rapidly desensitizing current responses. Treatment of heterologically expressed GluR6 with the lectin concanavalin A (ConA) inXenopus oocytes as well as in human embryonic kidney-293 cells results in a considerable increase of the steady-state current, presumably by inhibiting receptor desensitization. In the present study, we investigated the molecular basis of this effect using a systematic mutagenesis approach. We found that although N-glycosylation is an absolute prerequisite for the lectin-mediated inhibition of desensitization, no single one of the nine extracellular consensus sites for N-glycosylation of GluR6 is required. Rather, each of the nine N-linked carbohydrate side chains is independently capable of modulatory interaction with the lectin. Moreover, even artificially introduced N-glycosylation sites can substitute for native sites. Thus, the specific site of the lectin binding does not appear to be important for its desensitization-inhibiting action. Furthermore, we show that the extent of the receptor’s ConA sensitivity depends on its state of activation, because the desensitized GluR6 exhibits significantly lower lectin sensitivity than the nondesensitized receptor. We conclude that binding of ConA “locks” the receptor in the activatable state, thereby inhibiting conformational changes required to shift the receptor to the desensitized state.
Risks and Benefits of Dual Antiplatelet Therapy Beyond 12 Months After Coronary Stenting

AbstractThe optimal duration of dual antiplatelet therapy (DAT) after coronary stenting remains poorly define. The aim of this study was to evaluate the impact of longer than 24 months DAT in patients who received drug-eluting and bare-metal stents.A total of 1010 individuals who underwent elective, urgent or emergency coronary angioplasty with intended stent implantation at reference or specialized cardiac hospitals were randomized to receive long-term and short-term DAT to determine the benefits and adverse effects of long-term DAT. Total of 508 patients were randomized to long-term and 502 patients to <1 year DAT, and all of them were followed for more than 36 months for major adverse cardiac and cerebvascular events and bleeding major adverse cardiac and cerebvascular events (MACCE)Mean age of the 1010 patients (364 women and 646 men) was 60 years. Stent reocclusion occurred in 15 patients. Mean Syntax score was 23.00 ± 5.08 for whole samples, 25.00 ± 5.27 in 28 patients with MACCE and 23 ± 5.00 in 982 patients without MACCE (P = 0.057). According to all specified bleeding definitions, clopidogrel therapy for >12 months was not associated with a greater risk of hemorrhage. A regimen of >12 months of clopidogrel therapy in patients who had received drug-eluting or bare-metal stents did not differ significantly from a regimen of <12 months on clopidogrel with regard to MACCE.Long-term DAT might not significantly affect the reduction in the risk of death from any cause, myocardial infarction, or stroke, and not associated with minor or major bleeding events.
Emotion, succession, and the family firm: Josiah Wedgwood & Sons

We argue that both business history and social science studies of family firms often neglect the family qua family, in particular paying insufficient attention to the emotional elements of family as they affect family firms, separating out one from the other as distinctive variables, and treating each from a rationalising perspective. Adopting a microhistorical approach we use the case of succession at Josiah Wedgwood & Sons to argue that consideration of emotions and sensibilities provides new insight into behaviour at this world-famous firm.
Corked Hats and Coronation Street

This article contributes to the developing literature on childhood and national identity by considering the ways in which children imagine other nations. Focusing in particular on on-line interactions between children in 12 British and 12 New Zealand schools, the article explores their imaginative geographies of each other, and assesses the ways these visions are endorsed or contested by the children to whom they refer. The article not only illustrates the sources and importance of stereotypical understandings of landscape, people and patterns of daily life in other nations, but also the ways these may be contested through on-line contact.
Mulheres Negras e HIV: determinantes de vulnerabilidade na região serrana do estado do Rio de Janeiro

Trata-se de estudo de base quantitativa que teve como objetivo central analisar componentes socioculturais e comportamentais relacionados ao processo de vulnerabilizacao ao HIV/aids a partir da percepcao de mulheres negras na regiao serrana do estado do Rio de Janeiro. Para tal, foram entrevistadas 1.464 mulheres negras dos diferentes municipios que compoem essa regiao. Os principais determinantes que marcaram com maior intensidade a vulnerabilidade dessas mulheres associaram-se aos seguintes fatores: baixa escolaridade, renda e, consequentemente, acesso a bens e servicos, baixo indice de uso sistematico do preservativo e percepcoes de genero, que reforcam a menor autonomia feminina na tomada de decisoes protetoras.
Search for hepatopancreatic ecdysteroid-responsive genes during the crayfish molt cycle: from a single gene to multigenicity

SUMMARY The expression of the vitellogenin gene of the red-claw crayfish Cherax quadricarinatus (CqVg) was previously demonstrated in male crayfish during an endocrinologically induced molt cycle. The hypothesis that this expression is under the direct control of ecdysteroids was tested in this study both in vivo and in vitro. Unlike vitellogenin of insects, CqVg was not found to be ecdysteroid-responsive. Thus, a multigenic approach was employed for the identification of other hepatopancreatic ecdysteroid-responsive genes by a cDNA microarray. For the purposes of this study, a multi-parametric molt-staging technique, based on X-ray detection of gastrolith growth, was developed. To identify ecdysteroid-responsive genes during premolt, the molt cycle was induced by two manipulations, 20-hydroxyecdysone administration and X-organ–sinus gland complex removal; both resulted in significant elevation of ecdysteroids. Two clusters of affected genes (129 and 122 genes, respectively) were revealed by the microarray. It is suggested that only genes belonging to similarly responsive (up- or downregulated) gene clusters in both manipulations (102 genes) could be considered putative ecdysteroid-responsive genes. Some of these ecdysteroid-responsive genes showed homology to genes controlling chitin metabolism, proteases and other cellular activities, while 56.8% were unknown. The majority of the genes were downregulated, presumably by an energetic shift of the hepatopancreas prior to ecdysis. The effect of 20-hydroxyecdysone on representative genes from this group was confirmed in vitro using a hepatopancreas tissue culture. This approach for ecdysteroid-responsive gene identification could also be implemented in other tissues for the elucidation of ecdysteroid-specific signaling pathways during the crustacean molt cycle.
Automatic Object Segmentation by Quantum Cuts

In this study, the link between quantum mechanics and graph-cuts is exploited and a novel saliency map generation and salient object segmentation method is proposed based on the ground state solution of a modified Hamiltonian. First, the graph representation of certain quantum mechanical operators is studied. This reveals strong connections with widely used graph-cut algorithms while quantum mechanical constraints exhibit crucial advantages over the existing graph-cut algorithms. Furthermore, concepts such as potential field helps solving a particular singularity problem related to Laplacian matrices. In the proposed approach, the ground state (wave function) corresponding to a sub-atomic particle of a modified Hamiltonian operator corresponds to a particular optimization problem, the solution of which yields the salient object segmentation in a digital image. This approach provides a parameter-free -hence dataset independent-, unsupervised and fully automatic saliency map generation, which outperforms many existing state-of-the-art algorithms. The results of the proposed salient object extraction method exhibit such a promising accuracy that pushes the frontier in this field to the borders of the input-driven processing only - without the use of "object knowledge" aided by long-term human memory and intelligence. Furthermore, with the novel technologies for measuring a quantum wave function, the proposed method has a unique potential: Salient object segmentation in an actual physical setup in nano-scale. Such an unprece-dendent property will not only produce segmentation results instantaneously, but may be a unique opportunity to achieve accurate object segmentation in real-time for the massive visual repositories of today's "Big Data".