Miracle-dz/UniFAR-FTUs huggingface dataset:
Response to Hartwig and Davies

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The Relationship between Activity Level and Fatigue in Indonesian Children with Acute Lymphocytic Leukemia in the Home Setting

ABSTRACT Previous studies have examined physical exercise as a way to lower the fatigue of children with cancer in a hospital setting, but there have been no such studies in a home setting. Therefore, this study identifies the relationship between physical activity and fatigue in children undergoing chemotherapy at home. The design of this study is a cross-sectional correlation analysis. Forty-five children aged 3–16 years with acute lymphocytic leukemia residing in the greater Jakarta area in Indonesia were recruited using consecutive and snowball sampling methods. The relationship between physical activity and level of fatigue was assessed using the Spearman test. A statistically significant relationship was found between physical activity and fatigue in the children studied (p < 0.001). The active children had lower fatigue than the less active children. This study finds that higher physical activity is associated with lower fatigue in children with leukemia in a home setting. Nurses should educate children and their parents to promote physical activities at home in-between chemotherapy cycles.
Scrapie Affects the Maturation Cycle and Immune Complex Trapping by Follicular Dendritic Cells in Mice

Transmissible spongiform encephalopathies (TSEs) or prion diseases are infectious neurological disorders of man and animals, characterised by abnormal disease-associated prion protein (PrPd) accumulations in the brain and lymphoreticular system (LRS). Prior to neuroinvasion, TSE agents often accumulate to high levels within the LRS, apparently without affecting immune function. However, our analysis of scrapie-affected sheep shows that PrPd accumulations within the LRS are associated with morphological changes to follicular dendritic cells (FDCs) and tingible body macrophages (TBMs). Here we examined FDCs and TBMs in the mesenteric lymph nodes (MLNs) of scrapie-affected mice by light and electron microscopy. In MLNs from uninfected mice, FDCs could be morphologically categorised into immature, mature and regressing forms. However, in scrapie-affected MLNs this maturation cycle was adversely affected. FDCs characteristically trap and retain immune complexes on their surfaces, which they display to B-lymphocytes. In scrapie-affected MLNs, some FDCs were found where areas of normal and abnormal immune complex retention occurred side by side. The latter co-localised with PrPd plasmalemmal accumulations. Our data suggest this previously unrecognised morphology represents the initial stage of an abnormal FDC maturation cycle. Alterations to the FDCs included PrPd accumulation, abnormal cell membrane ubiquitin and excess immunoglobulin accumulation. Regressing FDCs, in contrast, appeared to lose their membrane-attached PrPd. Together, these data suggest that TSE infection adversely affects the maturation and regression cycle of FDCs, and that PrPd accumulation is causally linked to the abnormal pathology observed. We therefore support the hypothesis that TSEs cause an abnormality in immune function.
Multi-User Joint Subchannel and Power Resource-Allocation for Powerline Relay Networks

This paper investigates Orthogonal Frequency-Division Multiple-Access (OFDMA) resource-allocation schemes for two-hop relays in a home Powerline Communication (PLC) network. Unlike wireless channels, which can have noticeable path loss and shadow effects to bring a substantial relay gain, the powerline channel usually observes a quality of the relay channel on par with the direct link so that simple fixed relay configurations often lose performance instead of gaining any. Besides, the quasi-cyclostationary powerline channel benefits little from diversity combining, a scheme often found in cooperative wireless relay protocols to obtain performance improvements on fast fading channels. To address these special and challenging features of the powerline channel, Home-PLC relay protocols that jointly allocate subchannels and power to the source and relay nodes are proposed. Simulation results show that significant improvements of data rates can be achieved by jointly optimizing the subchannel and power allocation of Home-PLC relay networks.
CFIMon: Detecting violation of control flow integrity using performance counters

Many classic and emerging security attacks usually introduce illegal control flow to victim programs. This paper proposes an approach to detecting violation of control flow integrity based on hardware support for performance monitoring in modern processors. The key observation is that the abnormal control flow in security breaches can be precisely captured by performance monitoring units. Based on this observation, we design and implement a system called CFIMon, which is the first non-intrusive system that can detect and reason about a variety of attacks violating control flow integrity without any changes to applications (either source or binary code) or requiring special-purpose hardware. CFIMon combines static analysis and runtime training to collect legal control flow transfers, and leverages the branch tracing store mechanism in commodity processors to collect and analyze runtime traces on-the-fly to detect violation of control flow integrity. Security evaluation shows that CFIMon has low false positives or false negatives when detecting several realistic security attacks. Performance results show that CFIMon incurs only 6.1% performance overhead on average for a set of typical server applications.
Clinical perspective on aztreonam lysine for inhalation in patients with cystic fibrosis

Progressive obstructive lung disease is a characteristic component of cystic fibrosis (CF). It is the pulmonary manifestations, including obstruction and endobronchial infection, which directly contribute to the premature mortality of patients affected with CF. Due to the devastating effects on the pulmonary system, interest abounds in ways to improve antimicrobial delivery to the lungs and to impact clinical patient outcomes positively, whilst minimizing systemic toxicities. Recently, aztreonam lysine for inhalation solution, a new monobactam formulation, was approved by the US Food and Drug Administration for use in a subgroup of CF patients with Pseudomonas aeruginosa to improve respiratory symptoms. The purpose of this review is to present a summary of relevant pharmacologic, microbiologic, and clinical data related to the use of aztreonam lysine for inhalation in patients with CF.
Querying Log Data with Metric Temporal Logic

We propose a novel framework for ontology-based access to temporal log data using a datalog extension datalogMTL of the Horn fragment of the metric temporal logic MTL. We show that datalogMTL is EXPSPACE-complete even with punctual intervals, in which case full MTL is known to be undecidable. We also prove that nonrecursive datalogMTL is PSPACE-complete for combined complexity and in AC0 for data complexity. We demonstrate by two real-world use cases that nonrecursive datalogMTL programs can express complex temporal concepts from typical user queries and thereby facilitate access to temporal log data. Our experiments with Siemens turbine data and MesoWest weather data show that datalogMTL ontology-mediated queries are efficient and scale on large datasets.
The Neural Basis of Mark Making: A Functional MRI Study of Drawing

Compared to most other forms of visually-guided motor activity, drawing is unique in that it “leaves a trail behind” in the form of the emanating image. We took advantage of an MRI-compatible drawing tablet in order to examine both the motor production and perceptual emanation of images. Subjects participated in a series of mark making tasks in which they were cued to draw geometric patterns on the tablet's surface. The critical comparison was between when visual feedback was displayed (image generation) versus when it was not (no image generation). This contrast revealed an occipito-parietal stream involved in motion-based perception of the emerging image, including areas V5/MT+, LO, V3A, and the posterior part of the intraparietal sulcus. Interestingly, when subjects passively viewed animations of visual patterns emerging on the projected surface, all of the sensorimotor network involved in drawing was strongly activated, with the exception of the primary motor cortex. These results argue that the origin of the human capacity to draw and write involves not only motor skills for tool use but also motor-sensory links between drawing movements and the visual images that emanate from them in real time.
A long-term association between global temperature and biodiversity, origination and extinction in the fossil record

The past relationship between global temperature and levels of biological diversity is of increasing concern due to anthropogenic climate warming. However, no consistent link between these variables has yet been demonstrated. We analysed the fossil record for the last 520 Myr against estimates of low latitude sea surface temperature for the same period. We found that global biodiversity (the richness of families and genera) is related to temperature and has been relatively low during warm ‘greenhouse’ phases, while during the same phases extinction and origination rates of taxonomic lineages have been relatively high. These findings are consistent for terrestrial and marine environments and are robust to a number of alternative assumptions and potential biases. Our results provide the first clear evidence that global climate may explain substantial variation in the fossil record in a simple and consistent manner. Our findings may have implications for extinction and biodiversity change under future climate warming.
A semiempirical free energy force field with charge‐based desolvation

The authors describe the development and testing of a semiempirical free energy force field for use in AutoDock4 and similar grid‐based docking methods. The force field is based on a comprehensive thermodynamic model that allows incorporation of intramolecular energies into the predicted free energy of binding. It also incorporates a charge‐based method for evaluation of desolvation designed to use a typical set of atom types. The method has been calibrated on a set of 188 diverse protein–ligand complexes of known structure and binding energy, and tested on a set of 100 complexes of ligands with retroviral proteases. The force field shows improvement in redocking simulations over the previous AutoDock3 force field. © 2007 Wiley Periodicals, Inc. J Comput Chem, 2007
A Miracle That Accelerates Operating Room Functionality: Sugammadex

Background. Sugammadex offers a good alternative to the conventional decurarisation process currently performed with cholinesterase inhibitors. Sugammadex, which was developed specifically for the aminosteroid-structured rocuronium and vecuronium neuromuscular blockers, is a modified cyclodextrin made up of 8 glucose monomers arranged in a cylindrical shape. Methods. In this study, the goal was to investigate the efficacy of sugammadex. Sugammadex was used when there was insufficient decurarisation following neostigmine. This study was performed on 14 patients who experienced insufficient decurarisation (TOF <0.9) with neostigmine after general anaesthesia in the operating rooms of a university and a state hospital between June, 2012, and January, 2014. A dose of 2 mg/kg of sugammadex was administered. Results. Time elapsed until sugammadex administration following neostigmine 37 ± 6 min, following sugammadex it took 2.1 ± 0.9 min to reach TOF ≥0.9, and the extubation time was 3.2 ± 1.4 min. No statistically significant differences were detected in the hemodynamic parameters before and after sugammadex application. From the time of administration of sugammadex to the second postoperative hour, no side effects or complications occurred. None of the patients experienced acute respiratory failure or residual block during this time period. Conclusion. Sugammadex was successfully used to reverse rocuronium-induced neuromuscular block in patients where neostigmine was insufficient.
Absolute Molecular Orientational Distribution of the Polystyrene Surface

Vibrationally resonant sum frequency generation (VR-SFG) has been used to study the absolute molecular orientational distribution of the pendant phenyl groups at the free surface of polystyrene (PS) thin films on oxidized Si substrates. Characterization of the dependence of the VR-SFG on film thickness allows unique identification of the origin of the signal, e.g., free surface, bulk, or buried interface. For films <400 nm thick, the dominant source of vibrationally resonant signal is the PS/air interface, while the dominant source of the nonresonant background is the Si/SiO2 interface. VR-SFG of a self-assembled phenylsiloxane layer is used to calibrate the relative phase between the vibrationally resonant phenyl ring hyperpolarizability and the Si/SiO2 interface nonresonant hyperpolarizability. It is found that the phenyl groups are ordered at the PS/air interface and are oriented away from the polymer film. Quantitative analyses of the orientational distribution for both the PS free interface and the p.
Tobacco Usage in Uttarakhand: A Dangerous Combination of High Prevalence, Widespread Ignorance, and Resistance to Quitting

Background. Nearly one-third of adults in India use tobacco, resulting in 1.2 million deaths. However, little is known about knowledge, attitudes, and practices (KAP) related to smoking in the impoverished state of Uttarakhand. Methods. A cross-sectional epidemiological prevalence survey was undertaken. Multistage cluster sampling selected 20 villages and 50 households to survey from which 1853 people were interviewed. Tobacco prevalence and KAP were analyzed by income level, occupation, age, and sex. 95% confidence intervals were calculated using standard formulas and incorporating assumptions in relation to the clustering effect. Results. The overall prevalence of tobacco usage, defined using WHO criteria, was 38.9%. 93% of smokers and 86% of tobacco chewers were male. Prevalence of tobacco use, controlling for other factors, was associated with lower education, older age, and male sex. 97.6% of users and 98.1% of nonusers wanted less tobacco. Except for lung cancer (89% awareness), awareness of diseases caused by tobacco usage was low (cardiac: 67%; infertility: 32.5%; stroke: 40.5%). Conclusion. A dangerous combination of high tobacco usage prevalence, ignorance about its dangers, and few quit attempts being made suggests the need to develop effective and evidence based interventions to prevent a health and development disaster in Uttarakhand.
A Spaceborne Multisensory, Multitemporal Approach to Monitor Water Level and Storage Variations of Lakes

Lake Urmia, the second largest saline Lake on earth and a highly endangered ecosystem, is on the brink of a serious environmental disaster similar to the catastrophic death of the Aral Sea. Progressive drying has been observed during the last decade, causing dramatic changes to Lake Urmia’s surface and its regional water supplies. The present study aims to improve monitoring of spatiotemporal changes of Lake Urmia in the period 1975–2015 using the multi-temporal satellite altimetry and Landsat (5-TM, 7-ETM+ and 8-OLI) images. In order to demonstrate the impacts of climate change and human pressure on the variations in surface extent and water level, Lake Sevan and Van Lake with different characteristics were studied along with the Urmia Lake. Normalized Difference Water Index-Principal Components Index (NDWI-PCs), Normalized Difference Water Index (NDWI), Modified NDWI (MNDWI), Normalized Difference Moisture Index (NDMI), Water Ratio Index (WRI), Normalized Difference Vegetation Index (NDVI), Automated Water Extraction Index (AWEI), and MultiLayer Perceptron Neural Networks (MLP NNs) classifier were investigated for the extraction of surface water from Landsat data. The presented results revealed that MLP NNs has a better performance in the cases where the other models generate poor accuracy. The results show that the area of Lake Sevan and Van Lake have increased while the area of Lake Urmia has decreased by ~65.23% in the past decades, far more than previously reported (~25% to 50%). Urmia Lake’s shoreline has been receding severely between 2010 and 2015 with no sign of recovery, which has been partly blamed on prolonged droughts, aggressive regional water resources development plans, intensive agricultural activities, and anthropogenic changes to the system. The results also indicated that (among the proposed factors) changes in inflows due to overuse of surface water resources and constructing dams (mostly during 1995–2005) are the main reasons for Urmia Lake’s shoreline receding. The model presented in this manuscript can be used by managers as a decision support system to find the effects of building new dams or other infrastructures
3D Multi-Cell Simulation of Tumor Growth and Angiogenesis

We present a 3D multi-cell simulation of a generic simplification of vascular tumor growth which can be easily extended and adapted to describe more specific vascular tumor types and host tissues. Initially, tumor cells proliferate as they take up the oxygen which the pre-existing vasculature supplies. The tumor grows exponentially. When the oxygen level drops below a threshold, the tumor cells become hypoxic and start secreting pro-angiogenic factors. At this stage, the tumor reaches a maximum diameter characteristic of an avascular tumor spheroid. The endothelial cells in the pre-existing vasculature respond to the pro-angiogenic factors both by chemotaxing towards higher concentrations of pro-angiogenic factors and by forming new blood vessels via angiogenesis. The tumor-induced vasculature increases the growth rate of the resulting vascularized solid tumor compared to an avascular tumor, allowing the tumor to grow beyond the spheroid in these linear-growth phases. First, in the linear-spherical phase of growth, the tumor remains spherical while its volume increases. Second, in the linear-cylindrical phase of growth the tumor elongates into a cylinder. Finally, in the linear-sheet phase of growth, tumor growth accelerates as the tumor changes from cylindrical to paddle-shaped. Substantial periods during which the tumor grows slowly or not at all separate the exponential from the linear-spherical and the linear-spherical from the linear-cylindrical growth phases. In contrast to other simulations in which avascular tumors remain spherical, our simulated avascular tumors form cylinders following the blood vessels, leading to a different distribution of hypoxic cells within the tumor. Our simulations cover time periods which are long enough to produce a range of biologically reasonable complex morphologies, allowing us to study how tumor-induced angiogenesis affects the growth rate, size and morphology of simulated tumors.
Relationships Between Instructional Coaches’ Time Use and District- and School-Level Policies and Expectations

Whole-school reform models frequently include instructional coaching, yet instructional coaches typically spend relatively little time working with teachers on instruction. Using survey and interview data from district leaders, school administrators, and instructional coaches in one urban school district, this mixed-methods analysis asks how district- and school-level policies and expectations were related to coaches’ time use. Coaches accountable to district leaders spent more time working with teachers on instruction than their school-hired counterparts, who devoted more time to administrative and teaching duties. However, all coaches had limited opportunities to work with teachers in ongoing ways. Also, as district accountability systems became more robust, all coaches engaged in more administrative work. Implications for school and district policy are discussed.
Style Persistence, Pollen Limitation, and Seed Set in the Common Prairie Plant Echinacea angustifolia (Asteraceae)

Pollen limitation of seed set in flowering plants has important ramifications for the population dynamics, evolution, and conservation of plant populations. I conducted a pollen addition and exclusion experiment demonstrating that style persistence signifies pollen limitation in the narrow‐leaved purple coneflower Echinacea angustifolia, a species native to the North American prairie and plains. I developed a measure of style persistence, SP, a novel way to quantify pollen limitation in individual plants during the flowering season. Using this measure, I investigated the relationship between pollen limitation and seed set over two years in 19 and 27 natural remnant populations in an agricultural landscape. Population mean rates of seed set per plant varied from 0% to 54% in 1997 and from 0% to 63% in 1998. I found that pollen limitation reduced annual reproductive fitness within and among the populations studied. An analysis of the relationship between floret production and the rate of seed set provided no evidence that resource limitation influenced the rate of seed set. I estimated annual fecundity per plant as the product of the rate of seed set per floret, a pollen‐limited process, and floret production per plant, likely a resource‐limited process. Population means of individual annual fecundity ranged from 0 to 182 in 1997 and from 0 to 156 in 1998 and were predicted by population means of SP and the rate of seed set, but not by floret production. The effect of pollen limitation, as quantified by SP, overrides the strong, fundamental relationship between fecundity and floret production. This finding shows that populations consisting of large plants with large floral displays do not necessarily produce more seeds per plant.