Miracle-dz/UniFAR-FTUs huggingface dataset:
p16 expression in oropharyngeal cancer: its impact on staging and prognosis compared with the conventional clinical staging parameters.

BACKGROUND Currently, staging of head neck squamous cell carcinoma (HNSCC) is on the basis of primary tumor extension (cT), lymph node involvement (cN) and distant metastasis (cM). The aim of cancer staging was to improve diagnosis, prognosis and to compare outcome results. A new subgroup of oropharyngeal squamous cell carcinoma (OPSCC) induced by human papillomavirus (HPV) infection is reported to show an increasing incidence. These HPV-positive OPSCC show distinct molecular differences, specific p16 overexpression and a significantly better prognosis. Therefore, the aim of this study was to evaluate the prognostic influence of p16 expression in OPSCC and compare its relevance with the established prognostic markers cT and cN classification and the clinical stages I-IV. PATIENTS AND METHODS Immunohistochemistry for p16 was carried out on the basis of a tissue microarray including 102 OPSCC patients with corresponding retrospective clinicopathological and follow-up data. RESULTS p16 is the strongest independent prognostic marker in OPSCC, surpassing the significance of cT and cN classification as well as the clinical stages I-IV. Prognosis of p16-positive OPSCC of an advanced stage reached or even exceeded prognosis of the next clinically smaller conventionally staged group of tumors. CONCLUSION p16 is the most relevant prognostic marker in OPSCC and should be considered for inclusion into the official staging system of HNSCC.
HUBUNGAN ADVERSITY QUOTIENT DENGAN MOTIVASI BERWIRAUSAHA PADA MAHASISWA UNIVERSITAS UDAYANA YANG MENGIKUTI PROGRAM MAHASISWA WIRAUSAHA

PMW is one of the government initiative to support alumnus of university to be a job creator, but when college students choose to be entrepreneur surely there will be obstacles that must be overcome. Therefore need entrepreneur motivation to be up against that obstacles. One of factor which raises motivation is adversity quotient. Peoples who has adversity quotient are someone who had self motivation. College students need to have adversity quotient inside of their mind to motivate them in entrepreneurship. This research aims to know the relation between adversity quotient with entrepreneurship motivation in student of Udayana University who join PMW. This research using surfeited sample technique. The respondent in this research are students of Udayana University who join PMW with total 70 persons. Scales in this research are adversity quotient scale with total 42 items and entrepreneur motivation with total 38 items. Reliability coefficient of adversity quotient scale is 0.924 and entrepreneurship motivation is 0.941. This research used simple linear regression as additional. The result from this research showed correlation coefficient is 0.682 with probability score between variable is 0.000 which mean there are significant relation between entrepreneurship motivation variable. The coefficient determination R square is 0.465 which mean 46.5% entrepreneurship satisfaction can be explain by adversity quotient variable, however the rest 53.5% can be explain by another factor. Keywords: PMW, adversity quotient, entrepreneurship motivation
Text- and Content-based Approaches to Image Retrieval for the ImageCLEF 2009 Medical Retrieval Track

This article describes the participation of the Image and Text Integration (ITI) group from the United States National Library of Medicine (NLM) in the ImageCLEF 2009 medical retrieval track. Our methods encompass a variety of techniques relating to document summarization and text- and content-based image retrieval. Our text-based approach utilizes the Unied Medical Language System (UMLS) synonymy of concepts identied in information requests and image-related text to retrieve semantically relevant images. Our content-based approaches utilize similarity metrics based on computed \visual concepts" to identify visually similar images. In this article we present an overview of these approaches, discuss our experiences combining them into multimodal retrieval strategies, and describe our submitted runs and results.
Incorporation of Protease K into Larval Insect Membrane Vesicles Does Not Result in Disruption of Integrity or Function of the Pore-Forming Bacillus thuringiensisδ-Endotoxin

ABSTRACT Bacillus thuringiensis δ-endotoxins insert into the brush border membranes of insect larval cells to form ion channels. A possible interaction of these toxins with a cytoplasmic component was examined by preloading vesicles from insect larval cells with protease K followed by incubation with toxin. There was no evidence for toxin antigens smaller than the intact toxin in extracts of solubilized vesicles, nor was there an effect of the inclusion of protease K on either of two functional properties, the formation of toxin aggregates or of ion pores. These toxins, physically and functionally, appear to be confined to the membrane.
Impacts of Turbulence on Hurricane Intensity

Abstract : Our recent studies have shown that hurricane boundary layer turbulence, which must be parameterized in the current-generation weather-prediction models, plays a significant role in controlling the hurricane intensity. We find that horizontal turbulence, particularly in the radial direction (i.e., towards or away from the hurricane center), plays an important role in regulating hurricane intensity. The long-term goal of this project is thus to improve the hurricane intensity forecast by developing a more physically based horizontal turbulence parameterization scheme for hurricanes.
How Do Firms Finance Large Cash Flow Requirements

How do firms finance large cash flow requirements? We examine this in the context of firms that are subject to substantial cash flow requirements. We find that trade credit, inventory and cash stock reductions are all important in the short term for mild requirements. Larger and longer cash flow shortages give rise to more equity than debt finance. After the shocks, firms gradually adjust their leverage back to pre-shock levels by retiring debt and issuing equity. Financing patterns during a shock are consistent with a pecking-order theory of finance, whereas the adjustment afterwards is consistent with a trade-off theory.
ContexTour: Contextual Contour Analysis on Dynamic Multi-relational Clustering

Huge amounts of rich context social network data are generated everyday from various applications such as FaceBook and Twitter. These data involve multiple social relations which are community-driven and dynamic in nature. The complex interplay of these characteristics poses tremendous challenges on the users who try to understand the underlying patterns in the social media. We introduce an exploratory analytical framework, ContexTour, which generates visual representations for exploring multiple dimensions of community activities, including relevant topics, representative users and the community-generated content, as well as their evolutions. ContexTour consists of two novel and complementary components: (1) Dynamic Relational Clustering (DRC) that efficiently tracks the community evolution and smoothly adapts to the community changes, and (2) Dynamic Network Contour-map (DNC) that visualizes the community activities and evolutions in various dimensions. In our experiments, we demonstrate ContexTour through case studies on the DBLP dataset. The visual results capture interesting and reasonable evolution in Computer Science research communities. Quantitatively, we show 85-165X performance gain of our DRC algorithm over the baseline method.
PERCEPTION PRACTICE, PRODUCTION PRACTICE, AND MUSICAL ABILITY IN L2 MANDARIN TONE-WORD LEARNING

This study examined the differential effects of systematic perception and production practice and the role of musical ability in learning Mandarin tone-words by native English-speaking adults in a training study. In this study, all participants (N = 38; 19 for each practice group) were first taught declarative knowledge of Mandarin tones and of the target words on the first day. They had to reach criterion performance on the test of vocabulary before they started to engage in either perception or production practice on the second day. Each participant went through three practice sessions on three separate days. Immediate posttests assessing learning outcomes in both perceptive and productive skills were administered on the last day. Musical tonal ability tests were administered to all participants and used as a covariate. The results showed that performance was far worse when participants were tested on the reverse skill than when they were tested on the practiced skill in terms of both error rates and reaction times, providing strong support for the skill-specificity hypothesis. Musical tonal ability was found to correlate with accuracy performance in both tone-word perception and production.
Altered Food-Cue Processing in Chronically Ill and Recovered Women with Anorexia Nervosa

Anorexia nervosa (AN) is a severe mental disorder characterized by food restriction and weight loss. This study aimed to test the model posed by Brooks et al. (2012a,b) that women suffering from chronic AN show decreased food-cue processing activity in brain regions associated with energy balance and food reward (bottom-up; BU) and increased activity in brain regions associated with cognitive control (top-down; TD) when compared with long-term recovered AN (REC) and healthy controls (HC). Three groups of women, 15 AN (mean illness duration 7.8 ± 4.1 years), 14 REC (mean duration of recovery 4.7 ± 2.7 years) and 15 HC viewed alternating blocks of food and non-food images preceded by a short instruction during functional magnetic resonance imaging (fMRI), after fasting overnight. Functional region of interests (fROIs) were defined in BU (e.g., striatum, hippocampus, amygdala, hypothalamus, and cerebellum), TD (e.g., medial and lateral prefrontal cortex, and anterior cingulate), the insula, and visual processing areas (VPA). Food-cue processing activation was extracted from all fROIs and compared between the groups. In addition, functional connectivity between the fROIs was examined by modular partitioning of the correlation matrix of all fROIs. We could not confirm the hypothesis that BU areas are activated to a lesser extent in AN upon visual processing of food images. Among the BU areas the caudate showed higher activation in both patient groups compared to HC. In accordance with Brooks et al.’s model, we did find evidence for increased TD control in AN and REC. The functional connectivity analysis yielded two clusters in HC and REC, but three clusters in AN. In HC, fROIs across BU, TD, and VPA areas clustered; in AN, one cluster span across BU, TD, and insula; one across BU, TD, and VPA areas; and one was confined to the VPA network. In REC, BU, TD, and VPA or VPA and insula clustered. In conclusion, despite weight recovery, neural processing of food cues is also altered in recovered AN patients.
Dreaming, Reflective Consciousness, and Feelings in the Preschool Child

LeDoux (2015) discriminates creature consciousness, in which an organism is awake and alert, processing currently available stimuli, from mental-state consciousness, which is characterized by the possibility of reflection about current or past events and the ability to imagine new situations or scenarios. He establishes criteria for distinguishing the two, and finds no other animal that can experience conscious emotional feelings, nor more generally exhibit mental-state consciousness. A plausible extrapolation of his argument to humans suggests that they share this inability until about age 5. Tulving’s (2005) analysis of the development of episodic memory leads him to characterize the preschooler as anoetic, since the child is unable to encode conscious mental imagery capable of later recollection. Dreaming is another instance of mentalstate consciousness (Nir & Tononi, 2010), and the gold standard of research on dreaming is achieved in the modern sleep laboratory protocol. Longitudinal sleep laboratory studies have shown that dreaming is basically absent at ages 3 and 4, conforming to the general anoetic pattern of waking research on preschoolers, and confirming that dreaming also is a mental-state phenomenon. Resistance to accepting the sleep-laboratory data at face value seems to rest on an assumption that children must be inhibited by the laboratory setting, but this assumption already was refuted by direct home-lab comparisons in the same longitudinal project.
Puiseux series polynomial dynamics and iteration of complex cubic polynomials

Nous considerons la completion L du corps des series formelles de Puiseux et nous etudions les polynomes a coefficients dans L en tant que systemes dynamiques. Nous donnons une description complete de l'espace dynamique et l'espace des parametres des polynomes cubiques a coefficients dans L. Nous demontrons que la dynamique cubique sur L et sur C sont intimement liees. Plus precisement, nous montrons que certains elements de L correspondent de maniere naturelle a des series de Fourier de fonctions analytiques presque periodiques (au sens de Bohr) qui parametrisent (a l'infini) les classes quasi-conformes des polynomes complexes cubiques non renormalisables. Nos techniques s'appuient sur des idees introduites par Branner et Hubbard pour l'etude des polynomes cubiques complexes.
Interaction of alpha-actinin with the cadherin/catenin cell-cell adhesion complex via alpha-catenin

Cadherins are Ca(2+)-dependent, cell surface glycoproteins involved in cell-cell adhesion. Extracellularly, transmembrane cadherins such as E- , P-, and N-cadherin self-associate, while intracellularly they interact indirectly with the actin-based cytoskeleton. Several intracellular proteins termed catenins, including alpha-catenin, beta- catenin, and plakoglobin, are tightly associated with these cadherins and serve to link them to the cytoskeleton. Here, we present evidence that in fibroblasts alpha-actinin, but not vinculin, colocalizes extensively with the N-cadherin/catenin complex. This is in contrast to epithelial cells where both cytoskeletal proteins colocalize extensively with E-cadherin and catenins. We further show that alpha- actinin, but not vinculin, coimmunoprecipitates specifically with alpha- and beta-catenin from N- and E-cadherin-expressing cells, but only if alpha-catenin is present. Moreover, we show that alpha-actinin coimmunoprecipitates with the N-cadherin/catenin complex in an actin- independent manner. We therefore propose that cadherin/catenin complexes are linked to the actin cytoskeleton via a direct association between alpha-actinin and alpha-catenin.
Star formation histories of early-type galaxies at z = 1.2 in cluster and field environments

We derive the star formation histories of early-type galaxies at z � 1.2 in both low and high density environments. To this purpose, we compare the co-added spectroscopic and 8–9 band photometric data of 43 mass selected early-type galaxies in the massive cluster RDCS J1252.9-2927 and the GOODS/CDF-S field with a large grid of composite stellar population models based on the Bruzual & Charlot templates. We find that the cluster early-type galaxies formed the bulk of their stars approximately 0.5 Gyr earlier than earlytypes in the field, whereas field early-types presumably finish forming their stellar content on a longer time scale. Such a difference is particularly evident at masses 10 11 M� , whereas it becomes negligible for the most massive galaxies. While our differential analysis of the stellar population parameters of cluster and field galaxies in the same mass range convincingly shows distinct star formation histories, the absolute age difference remains model dependent. Using the star formation histories that best fit the SEDs of the red sequence galaxies in RDCS 1252.9-2927, we reconstruct the evolution of the cluster red sequence and find that it was established over 1 Gyr and is expected to dissolve by z ≈ 2.
Experiences of Heterosexual-Identified Counselors-in-Training With Lesbian, Gay, and Bisexual Couples in Relation to Perceived Training and Self-Efficacy

Experiences of Heterosexual-Identified Counselors-in-Training With Lesbian, Gay, and Bisexual Couples in Relation to Perceived Training and Self-Efficacy by Melissa L. Lee-Tammeus MA, Walden University, 2012 MA, Walden University, 2006 Dissertation Submitted in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy
Order Book Dynamics in Liquid Markets: Limit Theorems and Diffusion Approximations

We propose a model for the dynamics of a limit order book in a liquid market where buy and sell orders are submitted at high frequency. We derive a functional central limit theorem for the joint dynamics of the bid and ask queues and show that, when the frequency of order arrivals is large, the intraday dynamics of the limit order book may be approximated by a Markovian jump-diffusion process in the positive orthant, whose characteristics are explicitly described in terms of the statistical properties of the underlying order flow. This result allows to obtain tractable analytical approximations for various quantities of interest, such as the probability of a price increase or the distribution of the duration until the next price move, conditional on the state of the order book. Our results allow for a wide range of distributional assumptions and temporal dependence in the order flow and apply to a wide class of stochastic models proposed for order book dynamics, including models based on Poisson point processes, self-exciting point processes and models of the ACD-GARCH family.
Models for Old, Metal-poor Stars with Enhanced α-Element Abundances. III. Isochrones and Isochrone Population Functions

An isochrone population function (IPF) gives the relative distribution of stars along an isochrone. IPFs contain the information needed to calculate both luminosity functions and color functions, and they provide a straightforward way of generating synthetic stellar populations. An improved algorithm for interpolating isochrones and IPFs, based on the scheme introduced by Bergbusch & VandenBerg, is described. Software has been developed to permit such interpolations for any age encompassed by an input grid of stellar evolutionary tracks. Our first application of this software is to the models presented in this series of papers for 17 [Fe/H] values between -2.31 and -0.3, with three choices of [α/Fe] at each iron abundance (specifically, 0.0, 0.3, and 0.6). (These models do not treat gravitational settling or radiative acceleration processes, but otherwise they are based on up-to-date physics. Additional grids will be added to this database as they are completed.) The computer programs (written in FORTRAN 77) and the grids of evolutionary tracks that are presently available for processing by these codes into isochrones and IPFs are freely available to interested users. In addition, we add to the evidence presented in previous papers in this series in support of the Teff and color scales of our models. In particular, the temperatures derived by Gratton et al. for local Population II subdwarfs with accurate (Hipparcos) parallaxes are shown to be in excellent agreement with those predicted for them, when the Gratton et al. [Fe/H] scale is also assumed. Interestingly, the locus defined by local subdwarfs and subgiants on the (MV, log Teff)-plane and the morphologies of globular cluster (GC) color-magnitude diagrams are well matched by the present models, despite the neglect of diffusion, which suggests that some other process(es) must be at play to limit the expected effects of gravitational settling on predicted temperatures. The three field halo subgiants in our sample all appear to have ages ≳15 Gyr, which is favored for the Galaxy's most metal-poor GCs as well. (The settling of helium and heavy elements in the central regions of stars is expected to cause about a 10% reduction in these age estimates: this effect should persist even if some process, such as turbulence at the base of the convective envelope, counteracts diffusion in the surface layers.) Furthermore, our isochrones accurately reproduce the Da Costa & Armandroff red giant branch fiducials for M15, NGC 6752, NGC 1851, and 47 Tuc on the [MI, (V-I)0]-diagram. However, our models fail to predict the observed luminosities of the red giant bump by ≈0.25 mag: this could be an indication that there is some amount of inward overshooting of convective envelopes in red giants. For consistency reasons, the Zinn & West metallicities for intermediate metal-poor GCs (-1.8 ≳ [Fe/H] ≳ -1.1) seem to be preferred over recent spectroscopic results (based on the brightest cluster giants), suggesting that there is an inconsistency between current subdwarf and GC [Fe/H] scales.
Federal Reserve Bank of New York Staff Reports Is There an S&p 500 Index Effect? 1. Sample Construction 2. Changes in Stock Characteristics

paper presents preliminary findings and is being distributed to economists and other interested readers solely to stimulate discussion and elicit comments. The views expressed in this paper are those of the authors and are not necessarily reflective of views at the Federal Reserve Bank of New York or the Federal Reserve System. Any errors or omissions are the responsibility of the authors. Management Association meeting in New York, and the First Luxembourg Asset Management Summit for helpful comments and suggestions. The authors are grateful to Standard and Poor's for providing the list of S&P 500 index revisions. The views expressed in this paper are those of the authors and do not necessarily reflect the position of the Federal Reserve Bank of New York or the Federal Reserve System. Abstract We find that the firms included in the S&P 500 index are characterized by large increases in earnings, appreciation in market value, and positive price momentum in the period preceding their index inclusion. This strong preinclusion performance predicts 1) the permanent increase of market value and 2) the change in return comovement, reflected in declines of size, value, and momentum betas, following index inclusion. Nonevent firms with similar performance experience similar appreciation in value and changes in comovement coincident with the event firms. Contrary to the consensus in the literature, our results indicate that – after accounting for the firms' extraordinary preinclusion performance – index inclusion has no permanent effect on value and comovement. 1 A large body of literature argues for the existence of a Standard and Poor's (S&P) 500 index membership effect whereby inclusion in the S&P 500 index has a permanent impact on the price and beta of the event firms. In particular, studies of the value effect argue that index inclusion leads to a permanent increase in the market value of the event firms. 1 Further studies claim that index inclusion leads to an increase in comovement of the event firm's stock return with market and S&P 500 index returns. 2 While the literature provides different interpretations of the permanent effects following index inclusion, there is a consensus that these effects are the outcome of membership in the S&P 500 index rather than of the characteristics of the event firms. In this paper, we document that index-included firms exhibit extraordinary pre-event performance, such as large increases in earnings per share (EPS), appreciation in market value, positive price …