Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of Chronic Hypertension and Its Reversal on Arteries and Arterioles

The reversibility of functional and structural microvascular alterations in chronic renal hypertension has not been established. Twelve weeks after surgery to induce hypertension, in vivo arteriolar and venular dimensions were measured in the cremaster muscle of rats with one-kidney, one-clip hypertension (1K1C), rats in which the clip was removed after 8 weeks (1KNT), and controls. Systolic Mood pressure was significantly elevated after 3 days in 1K1C rats and reached a plateau by 6 weeks. In 1KNT rats, systolic blood pressures were similar to 1K1C rats but were normalized 1 day after unclipping. A marked medial-intimal hypertrophy was found by histological techniques in the thoracic and abdominal aortae (45% and 69%, respectively) but not in cremaster feeding arteries of 1K1C rats. These arterial changes were reversed after unclipping. In 1K1C rats, medial-intimal area decreased in first- through fourth-order (1A, 2A, 3A, and 4A) arterioles along with a decline in relaxed diameter (41%, 30%, 20%, and 21%, respectively), which was only partially restored after unclipping. Heart weight was increased by 67% in 1K1C rats, but it did not differ between 1KNT and controls. Therefore, the reversal of chronic renal hypertension can normalize gross structural alterations in the heart and large vessels, but more time may be required to normalize completely the arteriolar changes. These data indicate that long-term structural adaptations in renal hypertension are different in arterioles and arteries, and they may be related to chronic changes in blood flow and/or pressure.
The Second Release of the RASP System

We describe the new release of the RASP (robust accurate statistical parsing) system, designed for syntactic annotation of free text. The new version includes a revised and more semantically-motivated output representation, an enhanced grammar and part-of-speech tagger lexicon, and a more flexible and semi-supervised training method for the structural parse ranking model. We evaluate the released version on the WSJ using a relational evaluation scheme, and describe how the new release allows users to enhance performance using (in-domain) lexical information.
Intrinsic paleointensity bias and the long-term history of the geodynamo

A key mechanism responsible for a systematic bias in the global geomagnetic paleointensity database. Many geodynamo models predict an inverse relationship between geomagnetic reversal frequency and field strength. However, most of the absolute paleointensity data, obtained predominantly by the Thellier method from bulk volcanic rocks, fail to confirm this relationship. Although low paleointensities are commonly observed during periods of high reversal rate (notably, in the late Jurassic), higher than present-day intensity values are rare during periods of no or few reversals (superchrons). We have identified a fundamental mechanism that results in a pervasive and previously unrecognized low-field bias that affects most paleointensity data in the global database. Our results provide an explanation for the discordance between the experimental data and numerical models, and lend additional support to an inverse relationship between the reversal rate and field strength as a fundamental property of the geodynamo. We demonstrate that the accuracy of future paleointensity analyses can be improved by integration of the Thellier protocol with low-temperature demagnetizations.
Identification of Transcription Factor AML-1 Binding Site Upstream of Human Cytomegalovirus UL111A Gene

Human cytomegalovirus (HCMV) interleukin-10 (hcmvIL-10), encoded by HCMV UL111A gene, is a homolog of human IL-10. It exerts immunomodulatory effects that allow HCMV to evade host defense mechanisms. However, the exact mechanism underlying the regulation of hcmvIL-10 expression is not well understood. The transcription factor acute myeloid leukemia 1 (AML-1) plays an important role in the regulation of various genes involved in the differentiation of hematopoietic lineages. A putative AML-1 binding site is present within the upstream regulatory region (URR) of UL111A gene. To provide evidence that AML-1 is involved in regulating UL111A gene expression, we examined the interaction of AML-1 with the URR of UL111A in HCMV-infected human monocytic THP-1 cells using a chromatin immunoprecipitation assay. HcmvIL-10 transcription was detected in differentiated THP-1 cells, but not in undifferentiated ones. Furthermore, the URR of UL111A showed a higher intensity of AML-1 binding, a higher level of histone H3 acetyl-K9, but a lower level of histone H3 dimethyl-K9 in differentiated THP-1 cells than undifferentiated cells. Down-regulation of AML1 by RNA interference decreased the expression of the UL111A gene. Our results suggest that AML-1 may contribute to the epigenetic regulation of UL111A gene via histone modification in HCMV-infected differentiated THP-1 cells. This finding could be useful for the development of new anti-viral therapies.
Self-esteem and "if . . . then" contingencies of interpersonal acceptance.

The degree to which an individual perceives interpersonal acceptance as being contingent on successes and failures, versus relatively unconditional, is an important factor in the social construction of self-esteem. The authors used a lexical-decision task to examine people's "if. then" expectancies. On each trial, participants were shown a success or failure context word and then they made a word-nonword judgment on a second letter string, which sometimes was a target word relating to interpersonal outcomes. For low-self-esteem participants, success and failure contexts facilitated the processing of acceptance and rejection target words, respectively, revealing associations between performance and social outcomes. Study 2 ruled out a simple valence-congruency explanation. Study 3 demonstrated that the reaction-time pattern was stronger for people who had recently been primed with a highly contingent relationship, as opposed to one based more on unconditional acceptance. These results contribute to a social-cognitive formulation of the role of relational schemas in the social construction of self-esteem.
Annotation of Online Shopping Images without Labeled Training Examples

We are interested in the task of image annotation using noisy natural text as training data. An image and its caption convey different information, but are generated by the same underlying concepts. In this paper, we learn latent mixtures of topics that generate image and product descriptions on shopping websites by adapting a topic model for multilingual data (Mimno et al., 2009). We use the trained model to annotate test images without corresponding text. We capture visual properties such as color, texture, shape, and orientation by computing low-level image features, and measure the contribution of each type of visual feature towards the accuracy of the model. Our model significantly outperforms both a competitive baseline and a previous topic model-based system.
Music Therapy: Intimate Notes

1. Introduction: Finding our muses. PART I: MUSIC THERAPY WITH CHILDREN. 2. Daniel: Blossoms and baptism. 3. Wendy: 'I used to be crying every day. ' 4. Sinead: 'Here is my arm. ' 5. Giorgos: Isolation in a hospital ward. PART II: MUSIC THERAPY WITH ADULTS. 6. Martha: Working with wellness. 7. Shireen: Into the void of brain injury. 8. Olive and Jim: Senility and wisdom. 9. Mirian and Seaun: Danger and inimacy in a secure unit. 10. Mary and Steve: Creativity and terminal illness. 11. Conclusion: Intimate notes. Bibliography. Index.
ILoveSketch: as-natural-as-possible sketching system for creating 3d curve models

We present ILoveSketch, a 3D curve sketching system that captures some of the affordances of pen and paper for professional designers, allowing them to iterate directly on concept 3D curve models. The system coherently integrates existing techniques of sketch-based interaction with a number of novel and enhanced features. Novel contributions of the system include automatic view rotation to improve curve sketchability, an axis widget for sketch surface selection, and implicitly inferred changes between sketching techniques. We also improve on a number of existing ideas such as a virtual sketchbook, simplified 2D and 3D view navigation, multi-stroke NURBS curve creation, and a cohesive gesture vocabulary. An evaluation by a professional designer shows the potential of our system for deployment within a real design process.
Role profiles: an alternative look at personality in couples therapy

The purpose of this study was twofold. First, it aimed to test the recently developed personality assessment, Role Profiles, for its validity in the form of convergent validity analysis and cross structure analysis guided by role theory in which Role Profiles is grounded. Second, this study explored Role Profiles’ clinical implications by capturing participants’ subjective experiences of this assessment. Twenty couples recruited from the community completed the assessments, which included the Demographic Information form, the Rosenberg’s Self-Esteem scale, the Dyadic Adjustment scale, and the Role Balance scale. Upon completion of the assessments, participants were asked to complete the Role Profiles by placing seventy one cards of roles in one of four groups that best described how they felt about themselves at that moment. Four groups included “This Is Who I Am”, “This Is Who I Am Not”, “I Am Not Sure If This Is Who I Am”, and “This Is Who I Want To Be”. After the assessments, the couples were asked to answer two sets of open-ended questions about their subjective experiences of the Role Profiles. Findings of this study were consistent with previous studies on couples similarity and marital satisfaction: couples who shared many identical roles in their roles profiles were more likely to report higher satisfaction in their marriage. Furthermore, this study found a negative relationship between role confusion and self-esteem. Additionally, the results of this study indicated a statistically significant negative relationship between role confusion and marital satisfaction for husbands but not wives. The utility of the Role Profiles as a clinical assessment in couples therapy are discussed and suggestions are made for future research.
Effects on the Thermo-Mechanical and Crystallinity Properties of Nylon 6,6 Electrospun Fibres Reinforced with One Dimensional (1D) and Two Dimensional (2D) Carbon

Electrospun one dimensional (1D) and two dimensional (2D) carbon based polymer nanocomposites are studied in order to determine the effect provided by the two differently structured nanofillers on crystallinity and thermo-mechanical properties of the nanofibres. The nanomaterials studied are pristine carbon nanotubes, oxidised carbon nanotubes, reduced graphene oxide and graphene oxide. Functional groups associated with the order structure of the polymers are analysed by infrared and Raman spectroscopies; the morphology is studied by scanning electron microscopy and the crystallinity properties are investigated by differential scanning calorimetry and X-ray diffraction. Differences in crystallisation behaviour between 1D and 2D carbon based nanofibres are shown by their crystallinity degree and their crystal sizes. The nanocomposite crystal sizes perpendicular to the plane (100) decrease with nanofiller content in all cases. The crystallinity trend and crystal sizes are in accordance with storage modulus response. The results also suggest that functionalisation favours interfacial bonding and dispersion of the nanomaterials within the polymer matrix. As a consequence the number of nucleating sites increases which in turn decreases the crystal size in the nanocomposites. These features explain the improved thermo-mechanical properties in the nanocomposites.
Expression of Type III Hyperlipoproteinemia in Apolipoprotein E2 (Arg158→Cys) Homozygotes Is Associated With Hyperinsulinemia

Type III hyperlipoproteinemia (HLP) is mainly found in homozygous carriers of apolipoprotein E2 (apoE2, Arg158→Cys). Only a small percentage (<5%) of these apoE2 homozygotes develops hyperlipidemia, indicating that additional environmental and genetic factors contribute to the expression of type III HLP. In the present study, first, the prevalence of type III HLP among apoE2 homozygotes was estimated in a Dutch population sample of 8888 participants. Second, 68 normocholesterolemic and 162 hypercholesterolemic apoE2 homozygotes (type III HLP patients) were collected to investigate additional factors influencing type III HLP expression. In the Dutch population sample, apoE2 homozygosity occurred with a frequency of 0.6% (57 of 8888 individuals). Among the 57 E2/2 subjects, 10 type III HLP patients were identified (prevalence 18%). Comparison of normocholesterolemic E2/2 subjects and type III HLP patients showed that the latter had a significantly increased body mass index (25.6±4.0 versus 26.9±3.8 kg/m2, respectively;P =0.03) and prevalence of hyperinsulinemia (26% versus 63%, respectively;P <0.001). Multiple linear regression analysis demonstrated that most of the variability in type III HLP expression can be explained by fasting insulin levels (partial correlation coefficient ≈0.50, P <0.001). In contrast to men, apoE2 homozygous women aged ≥50 years had significantly higher plasma lipid levels than their counterparts aged <50 years. These data demonstrate that the expression of type III HLP in E2/2 subjects is elicited to a large extent by hyperinsulinemia. In addition, in female apoE2 homozygotes, the expression increases with age; this increase is most likely due to the loss of estrogen production.
StripeMaps: Improving Map-based Pedestrian Navigation for Smartwatches

Map applications for smartwatches present new challenges in cartography, a domain in which large display sizes have significant advantages. In this paper, we introduce StripeMaps, a system that adapts the mobile web design technique of linearization for displaying maps on the small screens of smartwatches. Just as web designers simplify multiple column desktop websites into a single column for easier navigation on mobile devices, StripeMaps transforms any two-dimensional route map into a one-dimensional "stripe". Through a user study, we show that this simplification allows StripeMaps to outperform both traditional mobile map interfaces and turn-by-turn directions for pedestrian navigation using smartwatches. In addition to introducing StripeMaps, this paper also has a secondary contribution. It contains the first empirical comparison of different approaches for pedestrian smartwatch navigation and illuminates their pros and cons.
Women and Children in a Bengali Village

We may not be able to make you love reading, but women and children in a bengali village will lead you to love reading starting from now. Book is the window to open the new world. The world that you want is in the better stage and level. World will always guide you to even the prestige stage of the life. You know, this is some of how reading will give you the kindness. In this case, more books you read more knowledge you know, but it can mean also the bore is full.
The psychology of learning applied to teaching

Of course, from childhood to forever, we are always thought to love reading. It is not only reading the lesson book but also reading everything good is the choice of getting new inspirations. Religion, sciences, politics, social, literature, and fictions will enrich you for not only one aspect. Having more aspects to know and understand will lead you become someone more precious. Yea, becoming precious can be situated with the presentation of how your knowledge much.
Factors contributing to institutionalization in patients with Huntington's disease

The objective of this study was to determine which factors are predictive of institutionalization in Huntington's disease. Seven hundred and ninety‐nine subjects with 4313 examinations from the Baltimore Huntington's Disease Center were included in the data set; 88 of these patients with an average follow‐up time of 9.2 years went from living at home to being institutionalized while being observed in our clinic. We examined demographic, genetic, and clinical variables for a relationship with institutionalization using linear regressions, a Cox proportional hazards model, and χ2 or t tests in certain cases. In our linear models, scores on the Quantified Neurologic Examination (R2 = 0.203, P < .001), Huntington's disease Activities of Daily Living Scale (R2 = 0.259, P < .001), and Motor Impairment Score (R2 = 0.173, P < .001) were found to have the strongest correlation with time until institutionalization. In addition, CAG repeat length (R2 = 0.248, P < .001) was significantly associated with disease duration at institutionalization, when controlling for age at onset. In the Cox proportional hazards model, scores on the Activities of Daily Living Scale, Mini–Mental State Examination, Quantified Neurologic Examination, and Motor Impairment Score all significantly predicted placement in long‐term care. Finally, institutionalized patients were shown to have a higher CAG number and a lower level of educational attainment than patients who avoided institutionalization for at least 15 years after disease onset. Neurologic findings, functional capacity, cognitive impairment, and CAG repeat length are all likely determinants of institutionalization. In contrast with other dementing conditions like Parkinson's and Alzheimer's, psychiatric symptoms were not shown to predict institutionalization in Huntington's disease. This may illustrate the especially debilitating nature of the movement disorder of Huntington's disease in comparison with the other dementias. © 2011 Movement Disorder Society
Atypical Manifestation of LPS-Responsive Beige-Like Anchor Deficiency Syndrome as an Autoimmune Endocrine Disorder without Enteropathy and Immunodeficiency

Monogenic primary immunodeficiency syndromes can affect one or more endocrine organs by autoimmunity during childhood. Clinical manifestations include type 1 diabetes mellitus, hypothyroidism, adrenal insufficiency, and vitiligo. Lipopolysaccharide (LPS)-responsive beige-like anchor protein (LRBA) deficiency was described in 2012 as a novel primary immunodeficiency, predominantly causing immune dysregulation and early onset enteropathy. We describe the heterogeneous clinical course of LRBA deficiency in two siblings, mimicking an autoimmune polyendocrine disorder in one of them in presence of the same underlying genetic mutation. The third child of consanguineous Egyptian parents (Patient 1) presented at 6 months of age with intractable enteropathy and failure to thrive. Later on, he developed symptoms of adrenal insufficiency, autoimmune hemolytic anemia, thrombocytopenia, and infectious complications due to immunosuppressive treatment. The severe enteropathy was non-responsive to the standard treatment and led to death at the age of 22 years. His younger sister (Patient 2) presented at the age of 12 to the endocrinology department with decompensated hypothyroidism, perioral vitiligo, delayed pubertal development, and growth failure without enteropathy and immunodeficiency. Using whole exome sequencing, we identified a homozygous frameshift mutation (c.6862delT, p.Y2288MfsX29) in the LRBA gene in both siblings. To our knowledge, our patient (Patient 2) is the first case of LRBA deficiency described with predominant endocrine phenotype without immunodeficiency and enteropathy. LRBA deficiency should be considered as underlying disease in pediatric patients presenting with autoimmune endocrine symptoms. The same genetic mutation can manifest with a broad phenotypic spectrum without genotype–phenotype correlation. The awareness for disease symptoms among non-immunologists might be a key to early diagnosis. Further functional studies in LRBA deficiency are necessary to provide detailed information on the origin of autoimmunity in order to develop reliable predictive biomarkers for affected patients.
Advances in NLP applied to Word Prediction

Presenting some recent advances in word prediction, a fluorishing research area in Natural Language Processing, we describe FastType, an innovative word prediction system that outclasses typical limitations of standard techniques when applied to inflected languages. FastType is based on combined statistical and rule-base methods relying on robust open-domain language resources, that have been refined to improve Keystroke Saving. Word prediction is particularly useful to minimise keystrokes for users with special needs, and to reduce misspellings for users having limited language proficiency. Word prediction can be effectively used in language learning, by suggesting correct words to non-native users. FastType has been tried out and evaluated in some test benchmarks, showing a relevant improvement in Keystroke Saving, which now reaches 51%, comparable to what achieved by word prediction methods for non-inflected languages.
Congruence between preferred and actual place of death according to the presence of malignant or non-malignant disease: a systematic review and meta-analysis

Objectives Achieving congruence between preferred and actual place of death is increasingly being used as a quantifiable indicator of the effectiveness of palliative care services. Current secular trends indicate a reversal of the institutionalisation of death, but this has been more pronounced in patients with malignant disease. As such, this study was conducted to evaluate whether the preservation of autonomy has been addressed equitably for cancer and non-cancer populations. Methods A systematic review and meta-analysis was performed in line with recommendations from Preferred Reporting Items for Systematic Reviews and Meta-Analyses and the Meta-analysis Of Observational Studies in Epidemiology (MOOSE) guidelines. A comprehensive computerised search of 14 databases, supplemented by a manual review of the literature was performed for all peer-reviewed publications, from 1980 to the present, identifying rates of incongruence for cancer and/or non-cancer cohorts. Aggregation of outcomes was performed using a random effects model. Results A total of 26 articles were identified that met the search and inclusion criteria. A non-cancer diagnosis was found to significantly increase the incidence of incongruence with a weighted risk ratio of 1.23 (95% CI 1.01 to 1.49, p=0.04) and this disparity appears to have increased since 2004. A moderate degree of heterogeneity was noted (I2=62%). Conclusions These findings pose a significant challenge, as a ‘good’ death has been closely matched to achieving patients’ wishes, including preferred place of death. Despite increasing awareness that those dying from chronic non-malignant diseases have extensive palliative care needs, much is still to be done to preserve their autonomy and reduce powerlessness in the face of death.