Miracle-dz/UniFAR-FTUs huggingface dataset:
Immunological Abnormalities in Patients with Chronic Fatigue Syndrome

Between January 1991 and January 1993, 265 patients who fulfilled the CDC criteria of the working case definition of Chronic Fatigue Syndrome (CFS) have been observed at our Institution and submitted for clinical and laboratory evaluation. One hundred and sixty‐three patients were females and 102 males, the median age was 35 years (range 4–55 years); all patients reported profound and prolonged fatigue, lasting for a median of 3 years (range 6 months–10 years), preceded or accompanied at appearance by fever in 185 cases, and neuropsychologic problems including inability to concentrate, difficulty in thinking, confusion, irritability, forgetfulness, and depression. The fatigue was so severe that it required 102 patients to stop their working activities for a period of time ranging from 3 months to 2 years (range 7 months). In 40 consecutive patients a comprehensive immunologic testing by single and two‐colour flow cytometry was performed and results compared with a group of 35 healthy, age‐ and sex‐matched controls. Whilst no significant differences were found in the absolute numbers of circulating total T cells (CD3+) and of total helper/inducer (CD4+) or suppressor/cytotoxic (CDS+) T cells, an evident reduction in CD3−/CD16+ and CD57+/CD56+ NK lymphocytes along with an expansion of the CD8+/CD56+ and CD16−/CD56+ NK subsets, were found in the CFS group. In addition, CD56+ NK cells from CFS subjects were found to express an increased amount of cell adhesion molecules (CD11b. CD1 1c, CD54) and activation antigens (CD38). Both the percentage and absolute numbers of CD4+ T cells bearing the CD45RA antigen appeared significantly reduced in CFS patients, and CD4+ T lymphocytes from CFS subjects displayed an increased expression of the intercellular adhesion molecule‐1 (ICAM− 1/CD54). Finally, the total numbers of circulating (CD19+) B lymphocytes, were significantly higher in CFS cases than in controls, and in 11 out of 30 CFS patients the increase in circulating B cells was sustained by the expansion of the CD5+/CD19+ subset of B lymphocytes. We conclude that CFS is a syndrome not previously described in Italy, with already known clinical characteristics and appears to be associated with several immunologic abnormalities, including those reported previously in cohort of patients from different countries. We also show for the first time that CD56+ NK cell subsets from CFS patients display an abnormally increased expression of cell adhesion molecules and activation markers.
An Exploratory Study of Older Adults' Engagement with Virtual Volunteerism

Virtual volunteering refers to the use of the Internet for volunteer services. It is an emerging phenomenon among every age group; however, the current study examines if it is a viable option for older people. Older adults are the fastest growing Internet users. They are also more civic minded than younger generations, thus the purpose of this study is to explore this relatively new area research. Data for this study have been collected using qualitative tools such as semistructured, partly open-ended interviews with older virtual volunteers affiliated with SeniorNet, an organization that facilitates virtual volunteering exclusively for older people. The study ends with suggestions for future research directions. Implications of this study include reconceptualization of virtual volunteering as a strategic tool to recruit older adults and greater usage of information communication technologies to promote civic engagement among older people and, thus, positively influence their health and well-being.
Double-blind comparison of the morphine sparing effect of continuous and intermittent i.m. administration of ketorolac.

The morphine sparing effect of ketorolac 10 mg administered 4-hourly by intermittent i.m. injection was compared with a continuous i.m. infusion in a double-blind, placebo-controlled trial in patients undergoing upper abdominal surgery. During the 48-h postoperative period, each patient was provided with a patient-controlled analgesia (PCA) system which delivered bolus doses of morphine and administered the intermittent i.m. doses automatically via a computer controlled pump. In the first 24 h after surgery, there was a significant reduction in morphine demanded by both groups receiving ketorolac compared with placebo. Patients who received a continuous infusion of ketorolac after abdominal surgery required a median dose of morphine by PCA which was 49% less than controls. In the second 24 h and over the entire 48 h of the study, patients in the continuous group required significantly less morphine than those in the placebo group. The intermittent group used less than the placebo group, but this was not significant.
Falciparum Malaria as an Emerging Cause of Fever in Adults Living in Gabon, Central Africa

Following the observed increase of malaria prevalence among older children in Gabon, a descriptive observational study was carried out in 2012 to determine the prevalence of malaria in adults presenting with fever in two health centres of Libreville, the capital city of Gabon. Thick- and thin-blood smears for malaria diagnosis were performed in febrile individuals aged more than 15 years old. Age, use of bed nets, previous antimalarial drug treatment, clinical symptoms, chest radiography results, and available haemoglobin data were also recorded. Among the 304 patients screened, the global malaria frequency was of 42.1% (n = 128/34). Plasmodium (P). falciparum was the only species identified. The proportion of patients with a clinical malaria requiring parenteral treatment was 38.5%, whereas 47.5% of outpatients had uncomplicated malaria. According to WHO classification, 14 (19.7%) infected patients had severe malaria; neurological and respiratory symptoms tended to be more frequent in case of P. falciparum infection. Anaemia was found in 51.5% adults and none had severe anaemia. Almost half of adults consulting for fever in two health centres of the urban city of Libreville have malaria. The use of insecticide-treated bed nets, the screening, and the treatment of individuals with P. falciparum microscopic and submicroscopic asymptomatic infection or clinical malaria should be emphasized to reduce the transmission.
Combining Climatic Projections and Dispersal Ability: A Method for Estimating the Responses of Sandfly Vector Species to Climate Change

Background In the Old World, sandfly species of the genus Phlebotomus are known vectors of Leishmania, Bartonella and several viruses. Recent sandfly catches and autochthonous cases of leishmaniasis hint on spreading tendencies of the vectors towards Central Europe. However, studies addressing potential future distribution of sandflies in the light of a changing European climate are missing. Methodology Here, we modelled bioclimatic envelopes using MaxEnt for five species with proven or assumed vector competence for Leishmania infantum, which are either predominantly located in (south-) western (Phlebotomus ariasi, P. mascittii and P. perniciosus) or south-eastern Europe (P. neglectus and P. perfiliewi). The determined bioclimatic envelopes were transferred to two climate change scenarios (A1B and B1) for Central Europe (Austria, Germany and Switzerland) using data of the regional climate model COSMO-CLM. We detected the most likely way of natural dispersal (“least-cost path”) for each species and hence determined the accessibility of potential future climatically suitable habitats by integrating landscape features, projected changes in climatic suitability and wind speed. Results and Relevance Results indicate that the Central European climate will become increasingly suitable especially for those vector species with a current south-western focus of distribution. In general, the highest suitability of Central Europe is projected for all species in the second half of the 21st century, except for P. perfiliewi. Nevertheless, we show that sandflies will hardly be able to occupy their climatically suitable habitats entirely, due to their limited natural dispersal ability. A northward spread of species with south-eastern focus of distribution may be constrained but not completely avoided by the Alps. Our results can be used to install specific monitoring systems to the projected risk zones of potential sandfly establishment. This is urgently needed for adaptation and coping strategies against the emerging spread of sandfly-borne diseases.
Maternal serum mannose-binding lectin in severe preeclampsia.

PURPOSE We aimed to investigate the level of serum mannose-binding lectin (MBL) in severe preeclamptic patients, women with uncomplicated pregnancies, and healthy reproductive-age females and its impact on gestational age at delivery and birth weight. METHODS Serum MBL levels were measured in 27 severe preeclampsia patients (Group 1), 27 patients with uncomplicated pregnancies (Group 2), and 25 healthy reproductive-age women (Group 3). RESULTS The mean serum MBL was significantly higher (p < or = 0.05) in Group 1 than in Groups 2 and 3, while the levels in Groups 2 and 3 did not significantly differ. The mean gestational age at delivery and mean birth weight were significantly lower in Group 1. In Group 1, serum MBL was negatively correlated (p < or = 0.05) with the gestational age at delivery and birth weight. CONCLUSION Serum MBL increased in preeclampsia and was negatively correlated with the gestational age at birth and birth weight, indicating an underlying immunopathogenesis.
Amphetamine-Associated Contextual Learning Is Accompanied by Structural and Functional Plasticity in the Basolateral Amygdala

Drug seeking and the vulnerability to relapse occur when individuals are exposed to an environment with sensory cues in which drug taking has occurred. Memory formation is thought to require plasticity in synaptic circuits, and so we examined whether the memory for a drug-paired environment correlates with changes in the synaptic circuits of the basolateral amygdala (BLA), in which emotional learning is a recognized phenomenon. We used amphetamine (AMPH) as the unconditioned stimulus in the conditioned place preference (CPP) paradigm. Rats were conditioned with 1.0 mg/kg AMPH and tested, drug free, 72 h after the last conditioning session. Controls included a saline-conditioned group and a home cage AMPH injection group, whose exposure to the CPP apparatus was delayed by 4 h, long enough to clear the AMPH from the brain. We counted excitatory synapses in the BLA using the electron microscope and the physical disector design (stereology). Rats that expressed AMPH CPP had an increase in excitatory synapses compared with controls. Excitatory synaptic activity was measured using in vivo intracellular recordings from the BLA in anesthetized rats. We found that AMPH CPP, but not drug alone, increased measures of synaptic drive, including the frequency of synaptic events, and the paired-pulse ratio of synaptic inputs to BLA pyramidal neurons. The in vivo findings suggest that the increase in BLA neuronal excitatory drive reflects the change in excitatory synapse number. Thus, context–drug associations are accompanied by structural and functional plasticity in the BLA, findings that have important implications for drug-seeking behavior.
Victims’ and Observers’ Reactions to Organizational Unfairness: The Role of Moral-Altruist Personality

Researchers are divided on the role of self-relevance in reactions to organizational unfairness: whether workers react similarly when the unfairness is directed at themselves or at others. We claim that the importance of self-relevance depends on moral-altruist personality (Honesty-Humility). In a vignette study, sensitivity to unfairness was weaker when the targets were coworkers rather than the participants, but only among those with low Honesty-Humility. In a field study, Honesty-Humility was associated with greater sensitivity to organizational fairness towards all workers but not to one's own treatment by the authority. Thus, morality-altruism mitigates the impact of self-relevance on attitudes following unfairness.
Bode-like control loop performance index evaluated for a class of fractional-order processes

Abstract Control loop performance assessment techniques are crucial for optimizing any plant or machine. They can bring huge energy and material savings and increase product quality. Usually, the performance is compared to minimum variance controller. It is known that when optimizing process controllers having fixed structure (e.g. PIDs) different concepts must be applied. In this paper, the systematic approach for a class of fractional-order processes is presented. Inspired by the model free design techniques, only a minimum a priori information about the process is assumed. A novel performance index based on 'ideal' shape of sensitivity function is proposed. Two fundamental limits are considered: available loop bandwidth and robustness MS-index. The best possible performance is computed for all processes belonging to the fractional-order model set controlled by PID-type controllers. The authors believe that the presented ideas may be utilized by both academic and industrial sphere.
Jargon Usage in Intervention Presentation During Consultation: Demonstration of a Facilitative Effect

Although previous research has investigated the effects on subsequent acceptance of the language used in intervention descriptions during consultation, most studies have confounded the effects of jargon with the effects of labeling and/or differing theoretical orientations or rationales. This study sought to isolate and assess the effects of technical language on acceptance of a common reductive intervention, time-out. Subjects included 67 experienced regular and special education teachers and 70 undergraduates. In contrast to previous research, results suggested that the presence of behavioral jargon can have a facilitative effect on teachers' acceptance of an intervention. No differences were found as a function of teacher experience. Undergraduates showed no preference for jargon in descriptions of time-out as did teachers. Results are compared to previous studies of the effects of jargon on intervention acceptability.
Insuring Educational Risk: Opportunities versus Income

We develop a model of education where individuals face educational risk. Successfully entering the skilled labor sector depends on individual effort in education and public resources, but educational risk still causes (income) inequality. We show that an optimal public policy consists of deferred skill-specific tuition fees, lump-sum transfers/taxes, and public funding of the educational sector. We argue that improved educational opportunities matter more than direct income transfers in a Second-best setting. Contrary to standard models of income risk, it is not optimal to use a proportional wage tax, because combining skill-specific tuition fees and public education spending provide both insurance and redistribution at lower costs. A wage tax is only optimal if skill-specific tuition fees are not available.
Job Security and Severance Pay Lenience in Recession

This paper presents an analysis of govern m nt policy to secure jobs in times of recession. In the Netherlands firms can choose to d issolve permanent worker contracts either through court or by requesting special permission f r m a public employment service. When permission is granted the firm is relieved from the obligation of severance pay. Severance pay lenience for firms in distress is a unique feature of the Dutch labor market. A simple theoretical equilibrium model is presented to study the policy’s effects. The model predicts that as long as the wage elasticity of labor demand does not exceed the inverse of the replacement ratio a system of severance payment exe mption is less costly than the alternative of additional unemployment benefits. The likelihood that this condition holds increases when a firm is hit by a negative shock. A novel data set on individual dismissal cases for the period 2006-2009 identifies key differences in procedural durations and firing costs distributions between the two firing options. These differences r sult from the severance pay exemption policy and form the main reasons to explain the out standing performance compared to EU countries of the Dutch labor market during the past decade.
Two Paths to Self-Employment?

This article contrasts the sociodemographic characteristics of self-employed women and men in both incorporated and unincorporated businesses. An analysis of 1980 Public Use Microsample (PUMS) data reveals that neither Schumpeter's (1934) “default” theory nor Knight's (1933) “career” theory offers an adequate explanation of women's self-employment. Women's family characteristics, which represent both constraint and choice, are significant predictors of women's self-employment. Human capital characteristics, including education, age, and past work experience are significant predictors of both women's and men's self-employment status. Self-employment is presented as a form of contingent work, which affords women schedule flexibility.
Can Life History Predict the Effect of Demographic Stochasticity on Extinction Risk?

Demographic stochasticity is important in determining extinction risks of small populations, but it is largely unknown how its effect depends on the life histories of species. We modeled effects of demographic stochasticity on extinction risk in a broad range of generalized life histories, using matrix models and branching processes. Extinction risks of life histories varied greatly in their sensitivity to demographic stochasticity. Comparing life histories, extinction risk generally increased with increasing fecundity and decreased with higher ages of maturation. Effects of adult survival depended on age of maturation. At lower ages of maturation, extinction risk peaked at intermediate levels of adult survival, but it increased along with adult survival at higher ages of maturation. These differences were largely explained by differences in sensitivities of population growth to perturbations of life-history traits. Juvenile survival rate contributed most to total demographic variance in the majority of life histories. Our general results confirmed earlier findings, suggesting that empirical patterns can be explained by a relatively simple model. Thus, basic life-history information can be used to assign life-history-specific sensitivity to demographic stochasticity. This is of great value when assessing the vulnerability of small populations.
Anti-ganglioside antibodies in patients with systemic lupus erythematosus and neurological manifestations

Introduction: Anti-ganglioside antibodies (AGA) have been associated with several peripheral neuropathies, such as Miller–Fisher syndrome, Guillain–Barré syndrome and multifocal motor neuropathy. They have also been studied in patients with systemic lupus erythematosus (SLE), focusing on neuropsychiatric manifestations and peripheral neuropathy, but the results are contradictory. Objective: To study the presence of AGA in a large cohort of patients with SLE and neuropsychiatric manifestations. Patients and methods: Serum from 65 consecutive patients with SLE and neuropsychiatric manifestations, collected from 1985 to 2009, was tested for the presence of AGA antibodies (GM1, GM2, GM3, asialo-GM1 GD1a, GD1b, GD3, GT1b, GQ1b) using a standard enzyme-linked immunosorbent assay ELISA test (INCAT 1999) and thin layer chromatography (TLC). Results: Positive results for asialo-GM1 (IgM) were found in 10 patients, 6 were positive for asialo-GM1 (IgM and IgG), and 4 were positive for other AGA such as GM1, GM2, GM3, GD1b, GT1b, GD3, (mainly IgM). Conclusions: Clinical and statistical studies showed no correlation between AGA and neuropsychiatric manifestations of SLE. Although some patients showed reactivity to AGA, these antibodies are not a useful marker of neuropsychiatric manifestations in SLE patients.
Neural Oscillations Associated with Item and Temporal Order Maintenance in Working Memory

The ability to retain information in working memory (WM) requires not only the active maintenance of information about specific items, but also the temporal order in which the items appeared. Although many studies have investigated the neural mechanisms of item maintenance, little is known about the neural mechanisms of temporal order maintenance in WM. Here, we used electroencephalography (EEG) to compare neural oscillations during WM tasks that required maintenance of item or temporal order information. Behavioral results revealed that accuracy and reaction times were comparable between the two conditions, suggesting that task difficulty was matched between the item and temporal order WM tasks. EEG analyses indicated that theta (5–7 Hz) oscillations over prefrontal sites were increased during temporal order maintenance, whereas alpha oscillations (9–12 Hz) over posterior parietal and lateral occipital sites were increased during item maintenance. The frontal theta enhancement was primarily evident in high performers on the order WM task, whereas the posterior alpha enhancement was primarily evident in high performers on the item WM task. These results support the idea that frontal theta and posterior alpha oscillations are differentially related to maintenance of item and temporal order information.
Investigating Energy-Saving Potentials in the Cloud

Collecting webpage messages can serve as a sensor for investigating the energy-saving potential of buildings. Focusing on stores, a cloud sensor system is developed to collect data and determine their energy-saving potential. The owner of a store under investigation must register online, report the store address, area, and the customer ID number on the electric meter. The cloud sensor system automatically surveys the energy usage records by connecting to the power company website and calculating the energy use index (EUI) of the store. Other data includes the chain store check, company capital, location price, and the influence of weather conditions on the store; even the exposure frequency of store under investigation may impact the energy usage collected online. After collecting data from numerous stores, a multi-dimensional data array is constructed to determine energy-saving potential by identifying stores with similarity conditions. Similarity conditions refer to analyzed results that indicate that two stores have similar capital, business scale, weather conditions, and exposure frequency on web. Calculating the EUI difference or pure technical efficiency of stores, the energy-saving potential is determined. In this study, a real case study is performed. An 8-dimensional (8D) data array is constructed by surveying web data related to 67 stores. Then, this study investigated the savings potential of the 33 stores, using a site visit, and employed the cloud sensor system to determine the saving potential. The case study results show good agreement between the data obtained by the site visit and the cloud investigation, with errors within 4.17%. Among 33 the samples, eight stores have low saving potentials of less than 5%. The developed sensor on the cloud successfully identifies them as having low saving potential and avoids wasting money on the site visit.
Face Video Retrieval via Deep Learning of Binary Hash Representations

Retrieving faces from large mess of videos is an attractive research topic with wide range of applications. Its challenging problems are large intra-class variations, and tremendous time and space complexity. In this paper, we develop a new deep convolutional neural network (deep CNN) to learn discriminative and compact binary representations of faces for face video retrieval. The network integrates feature extraction and hash learning into a unified optimization framework for the optimal compatibility of feature extractor and hash functions. In order to better initialize the network, the low-rank discriminative binary hashing is proposed to pre-learn hash functions during the training procedure. Our method achieves excellent performances on two challenging TV-Series datasets.