Miracle-dz/UniFAR-FTUs huggingface dataset:
Bifidobacterium longum CECT 7347 Modulates Immune Responses in a Gliadin-Induced Enteropathy Animal Model

Coeliac disease (CD) is an autoimmune disorder triggered by gluten proteins (gliadin) that involves innate and adaptive immunity. In this study, we hypothesise that the administration of Bifidobacterium longum CECT 7347, previously selected for reducing gliadin immunotoxic effects in vitro, could exert protective effects in an animal model of gliadin-induced enteropathy. The effects of this bacterium were evaluated in newborn rats fed gliadin alone or sensitised with interferon (IFN)-γ and fed gliadin. Jejunal tissue sections were collected for histological, NFκB mRNA expression and cytokine production analyses. Leukocyte populations and T-cell subsets were analysed in peripheral blood samples. The possible translocation of the bacterium to different organs was determined by plate counting and the composition of the colonic microbiota was quantified by real-time PCR. Feeding gliadin alone reduced enterocyte height and peripheral CD4+ cells, but increased CD4+/Foxp3+ T and CD8+ cells, while the simultaneous administration of B. longum CECT 7347 exerted opposite effects. Animals sensitised with IFN-γ and fed gliadin showed high cellular infiltration, reduced villi width and enterocyte height. Sensitised animals also exhibited increased NFκB mRNA expression and TNF-α production in tissue sections. B. longum CECT 7347 administration increased NFκB expression and IL-10, but reduced TNF-α, production in the enteropathy model. In sensitised gliadin-fed animals, CD4+, CD4+/Foxp3+ and CD8+ T cells increased, whereas the administration of B. longum CECT 7347 reduced CD4+ and CD4+/Foxp3+ cell populations and increased CD8+ T cell populations. The bifidobacterial strain administered represented between 75–95% of the total bifidobacteria isolated from all treated groups, and translocation to organs was not detected. These findings indicate that B. longum attenuates the production of inflammatory cytokines and the CD4+ T-cell mediated immune response in an animal model of gliadin-induced enteropathy.
The Hydrologic Importance of Small- and Medium-Sized Dams: Examples from Texas

Studies of the effects of dams have emphasized large and very large dams; less well understood are the impacts caused by smaller dams. Using Texas as an example area, this article highlights the role of small- and medium-sized dams in affecting the surface hydrology of river systems. Analysis of data from the National Inventory of Dams (NID) in a geographic information system showed that small and medium dams comprise about 97 percent of the dams registered in Texas. A small-or medium-sized dam is found approximately every 100 km2 of area and about 120 km of river length. Different from large dams, which affect water storage the most, the major impact of these smaller dams is fragmentation of river landscapes. Analysis of data for dams extracted from digital orthoquads and for water bodies from the National Hydrography Dataset indicates that the extent of river fragmentation is likely greater than that suggested by data from the NID, because the NID underrepresents the smaller dams. Such extent of river fragmentation can degrade stream habitats and pose barriers to the migration of aquatic species and transport of sediment. Because small and medium dams are largely built for fire protection and stock ponds, mitigating the impacts associated with these dams likely involves working with the private individuals who own them.
Response of Northwest Douglas-fir Stands to Urea: Correlations with Forest Soil Properties 1

Replicated forest fl oor and surface soil (0–15 cm) samples were obtained from control plots at 160 fi eld installations to western Washington and Oregon. Six year growth responses of thinned and unthinned Douglas-fi r [Pseudotsuga menziesii (Mirb.) Franco] in stallations treated with 0, 224, and 448 kg of urea-N ha were correlated with 18 forest fl oor and surface soil properties of the control plots. Correlations for response with respective forest fl oor and soil data were produced for levels of fertilizer application and both basal area and volume response. Observed and estimated expressions of absolute and relative response were used in analyses. Forest fl oor nitrogen properties were the most highly correlated with various estimates of response in both thinned and unthinned stands; these correlations were generally independent of methods used to estimate response. For unthinned stands, C/N ratios of both forest fl oor and surface soil were well correlated with growth response to fertilizer, whereas for thinned stands, N content (kilograms per hectare) of the forest fl oor was consistently correlated with response. Response of Northwest Douglas-fi r Stands to Urea: Correlations with Forest Soil Properties C. E. PETERSON, P. J. RYAN, AND S. P. Gessel Additionsal Index Words: forest fertilization, response classifi cation, sample size, forest fl oor, decomposition, thinning. Peterson, C.E. , P.J. Ryan, and S.P. Gessel. 1984. Response of northwest Douglas-fi r stands to urea: Correlations with forest soil properties. Soil Sci. Soc. Am. J. 48:162–169. NITROGENOUS FERTILIZER has been applied to Douglas-fi r stands on an operational basis for about 10 yr in the Pacifi c Northwest (Bengston, 1979) and over 1 million ha have been treated. Considerable land area has had at least one repeat application of nitrogen. In most instances nitrogen has been applied as urea at a rate of 224 kg ha as elemental N. This aspect of intensive management emphasizes the longrun expectation of increased growth rate from nitrogen fertilization by both public and private forest landowners. A major source of information for Douglas-fi r [Pseudotsuga menziesii (Mirb.) Franco] growth response in the Northwest has been the Regional Forest Nutrition Research Project (RFNRP). The project was initiated in 1969 as a cooperative effort to determine average regional growth response of Douglas-fi r and western hemlock [Tsuga heterophylla (Raf) Sarg. ] stands to nitrogen fertilizer. Response has been defi ned for this study as 1 Sponsored by the Regional Forest Nutrition Res. Project, College of Forest Resources, Univ. of Washington Seattle, WA 98195. Received 4 Apr. 1983. Approved 22 Aug. 1983. 2 Mensuration Director of Regional Forest Nutrition Res. Project, former Graduate Student, and Professor of Forest Soils,
[Photodynamic therapy with verteporfin in choroidal neovascularization after refractive surgery].

PURPOSE To analyze the results obtained with Photodynamic Therapy (PDT) to treat subfoveal and juxtafoveal Choroidal Neovascularization (CNV) in patients with high myopia corrected by Laser-Assisted in situ Keratomileusis (LASIK) or by implanting a Phakic Intraocular Lens (PIOL). METHODS We analyzed the results from 14 highly myopic eyes corrected by LASIK (seven cases) or by PIOL implantation (seven cases), which later developed CNV and were treated by PDT with verteporfin. RESULTS Mean Best Corrected Visual Acuity (BCVA) after refractive surgery was 0.45 SD 0.17 (range, 0.2 to 0.8), with residual spherical equivalent (RSE) -0.5 SD 1.8 D (range, 1 to 5.5 D). After CNV appearance, BCVA was 0.10 SD 0.19 (range, 0.025 to 0.7). CNV was treated in all cases by PDT (mean, 2.0 SD 0.8 treatments). After CNV closure, the mean BCVA improved up to 0.22 SD 0.18 (range, 0.1 to 0.63) (RSE -1.4 SD 1.4 D, range, 0.5 to -4 D). Differences in RSE after refractive surgery and after PDT, and differences between BCVA after CNV appearance and final were not statistically significant (p=0.82 and p=0.06, respectively, Student's t test paired data). CONCLUSION We consider that PDT is effective in achieving closure of CNV in myopic patients after refractive surgery without inducing changes in spherical equivalent.
Ellipsoidal variability and the difference between sequence D and E red giants

We have studied a sample of Large Magellanic Cloud red giant binaries that lie on sequence E in the period–luminosity plane. We show that their combined light and velocity curves unambiguously demonstrate that they are binaries showing ellipsoidal variability. By comparing the phased light and velocity curves of both sequence D and E variables, we show that the sequence D variation – the long secondary period – is not caused by ellipsoidal variability. We also demonstrate several further differences between stars on sequences D and E. These include differences in velocity amplitude, in the distribution of eccentricity and in the correlations of velocity amplitude with luminosity and period. We also show that the sequence E stars, unlike stars on sequence D, do not show any evidence of a mid-infrared excess that would indicate circumstellar dust.
An ultrawide-band semiconductor optical amplifier having an extremely high penalty-free output power of 23 dBm achieved with quantum dots

A semiconductor optical amplifier (SOA) having a gain of >25 dB, noise figure of <5 dB, and 3-dB saturation output power of >19 dBm, over the record widest bandwidth of 90 nm among all kinds of optical amplifiers, and also having a penalty-free output power of 23 dBm, the record highest among all the SOAs, was realized by using quantum dots.
Body image and personality predictors of eating disorder symptoms during the college years.

OBJECTIVE Women entering college (N = 118) were longitudinally followed for 3 years with assessments of eating pathology (Restraint and Bulimia). METHOD Measures taken at Time 1 included timing of onset of puberty, Figure Dissatisfaction, Ineffectiveness, Public Self-Consciousness, and mood states (Profile of Mood States). Measures were evaluated as predictors of changes in Restraint and Bulimia scores across the three-year period. RESULTS Both Restraint (r = .69) and Bulimia (r = .50) were quite stable across the 3 years. Mean weight gain of 5.4 pounds (p < .001) was paralleled by an increase in "ideal weight" of 4.7 pounds. Hierarchical regressions controlling for Time 1 levels of eating disorder symptoms revealed that changes in Bulimia (R(2) = . 38, p < . 0001) were related to the psychological measures and to Figure Dissatisfaction. Changes in Restraint (R(2) = . 61, p < . 0001) were significantly related to Figure Dissatisfaction. DISCUSSION Findings are discussed in the context of the value of longitudinal designs in identifying risk factors. Dissatisfaction with one's figure seems to be consistently related to worsening eating pathology.
CFH, C3 and ARMS2 Are Significant Risk Loci for Susceptibility but Not for Disease Progression of Geographic Atrophy Due to AMD

Background Age-related macular degeneration (AMD) is a prevalent cause of blindness in Western societies. Variants in the genes encoding complement factor H (CFH), complement component 3 (C3) and age-related maculopathy susceptibility 2 (ARMS2) have repeatedly been shown to confer significant risks for AMD; however, their role in disease progression and thus their potential relevance for interventional therapeutic approaches remains unknown. Methodology/Principal Findings Here, we analyzed association between variants in CFH, C3 and ARMS2 and disease progression of geographic atrophy (GA) due to AMD. A quantitative phenotype of disease progression was computed based on longitudinal observations by fundus autofluorescence imaging. In a subset of 99 cases with pure bilateral GA, variants in CFH (Y402H), C3 (R102G), and ARMS2 (A69S) are associated with disease (P = 1.6×10−9, 3.2×10−3, and P = 2.6×10−12, respectively) when compared to 612 unrelated healthy control individuals. In cases, median progression rate of GA over a mean follow-up period of 3.0 years was 1.61 mm2/year with high concordance between fellow eyes. No association between the progression rate and any of the genetic risk variants at the three loci was observed (P>0.13). Conclusions/Significance This study confirms that variants at CFH, C3, and ARMS2 confer significant risks for GA due to AMD. In contrast, our data indicate no association of these variants with disease progression which may have important implications for future treatment strategies. Other, as yet unknown susceptibilities may influence disease progression.
Influencing Food Choices by Training: Evidence for Modulation of Frontoparietal Control Signals

To overcome unhealthy behaviors, one must be able to make better choices. Changing food preferences is an important strategy in addressing the obesity epidemic and its accompanying public health risks. However, little is known about how food preferences can be effectively affected and what neural systems support such changes. In this study, we investigated a novel extensive training paradigm where participants chose from specific pairs of palatable junk food items and were rewarded for choosing the items with lower subjective value over higher value ones. In a later probe phase, when choices were made for real consumption, participants chose the lower-valued item more often in the trained pairs compared with untrained pairs. We replicated the behavioral results in an independent sample of participants while they were scanned with fMRI. We found that, as training progressed, there was decreased recruitment of regions that have been previously associated with cognitive control, specifically the left dorsolateral pFC and bilateral parietal cortices. Furthermore, we found that connectivity of the left dorsolateral pFC was greater with primary motor regions by the end of training for choices of lower-valued items that required exertion of self-control, suggesting a formation of a stronger stimulus–response association. These findings demonstrate that it is possible to influence food choices through training and that this training is associated with a decreasing need for top–down frontoparietal control. The results suggest that training paradigms may be promising as the basis for interventions to influence real-world food preferences.
Performance of Insulators Covered With Snow or Ice

This paper describes the results of investigation made into the performance of insulators covered with snow or ice. The AC and DC withstand voltages of snow-covered insulators were characterized by the conductivity of water melted from the snow. The AC withstand voltage of ice-coated insulators was characterized by the length of icicles and conductivity of the water melted from the ice. And the switching impulse flashover voltage of snow-covered insulator strings was almost proportional to gap length between the arcing horns or the insulator strings. Flashover voltage of a 75% snow-covered insulator string, which means the worst case, was 40 ¿65% of the positive wet flashover voltage of the clean insulator string.
Embers of society: Firelight talk among the Ju/’hoansi Bushmen

Significance Control of fire and the capacity for cooking led to major anatomical and residential changes for early humans, starting more than a million years ago. However, little is known about what transpired when the day was extended by firelight. Data from the Ju/’hoan hunter-gatherers of southern Africa show major differences between day and night talk. Day talk centered on practicalities and sanctioning gossip; firelit activities centered on conversations that evoked the imagination, helped people remember and understand others in their external networks, healed rifts of the day, and conveyed information about cultural institutions that generate regularity of behavior and corresponding trust. Appetites for firelit settings for intimate conversations and for evening stories remain with us today. Much attention has been focused on control of fire in human evolution and the impact of cooking on anatomy, social, and residential arrangements. However, little is known about what transpired when firelight extended the day, creating effective time for social activities that did not conflict with productive time for subsistence activities. Comparison of 174 day and nighttime conversations among the Ju/’hoan (! Kung) Bushmen of southern Africa, supplemented by 68 translated texts, suggests that day talk centers on economic matters and gossip to regulate social relations. Night activities steer away from tensions of the day to singing, dancing, religious ceremonies, and enthralling stories, often about known people. Such stories describe the workings of entire institutions in a small-scale society with little formal teaching. Night talk plays an important role in evoking higher orders of theory of mind via the imagination, conveying attributes of people in broad networks (virtual communities), and transmitting the “big picture” of cultural institutions that generate regularity of behavior, cooperation, and trust at the regional level. Findings from the Ju/’hoan are compared with other hunter-gatherer societies and related to the widespread human use of firelight for intimate conversation and our appetite for evening stories. The question is raised as to what happens when economically unproductive firelit time is turned to productive time by artificial lighting.
Temperature sensitivity of plant phenology in temperate and subtropical regions of China from 1850 to 2009

Phenology can be used to track plant responses to climate change. In China, several studies have found the earlier trends of spring phenophases over the past 50 years. However, few studies put these phenological changes into historical perspective. Based on specific phenophases records from historical diaries and Chinese Phenological Observation Network, we developed spring phenology index (SPI) time series in temperate and subtropical regions of eastern China from 1850 to 2009. We firstly compare the temporal change of SPI and seasonal temperature anomaly. Subsequently, we search for common shifts in phenological and temperature time series by applying the moving t‐test method, and discuss temperature sensitivity of SPI by using the moving linear regression method for both regions. Results show that the SPI in temperate region revealed lower interannual variability than in subtropical region, while the seasonal temperature variability was higher in temperate region. In temperate region, the timing of significant shift towards earlier SPI (in 1979) coincides with the timing of shift in spring temperature time series. The temperature sensitivities of SPI differ among the two regions. The mean sensitivity of SPI to spring temperature in subtropical region (−3.7 days °C−1) is stronger than in temperate region (−2.5 days °C−1). The temperature sensitivity of SPI varies among consecutive 30‐year periods. In recent three decades, temperature sensitivity of spring phenophases became stronger in both regions.
Invasion Pathway of the Ctenophore Mnemiopsis leidyi in the Mediterranean Sea

Gelatinous zooplankton outbreaks have increased globally owing to a number of human-mediated factors, including food web alterations and species introductions. The invasive ctenophore Mnemiopsis leidyi entered the Black Sea in the early 1980s. The invasion was followed by the Azov, Caspian, Baltic and North Seas, and, most recently, the Mediterranean Sea. Previous studies identified two distinct invasion pathways of M. leidyi from its native range in the western Atlantic Ocean to Eurasia. However, the source of newly established populations in the Mediterranean Sea remains unclear. Here we build upon our previous study and investigate sequence variation in both mitochondrial (Cytochrome c Oxidase subunit I) and nuclear (Internal Transcribed Spacer) markers in M. leidyi, encompassing five native and 11 introduced populations, including four from the Mediterranean Sea. Extant genetic diversity in Mediterranean populations (n = 8, N a = 10) preclude the occurrence of a severe genetic bottleneck or founder effects in the initial colonizing population. Our mitochondrial and nuclear marker surveys revealed two possible pathways of introduction into Mediterranean Sea. In total, 17 haplotypes and 18 alleles were recovered from all surveyed populations. Haplotype and allelic diversity of Mediterranean populations were comparable to populations from which they were likely drawn. The distribution of genetic diversity and pattern of genetic differentiation suggest initial colonization of the Mediterranean from the Black-Azov Seas (pairwise F ST = 0.001–0.028). However, some haplotypes and alleles from the Mediterranean Sea were not detected from the well-sampled Black Sea, although they were found in Gulf of Mexico populations that were also genetically similar to those in the Mediterranean Sea (pairwise F ST = 0.010–0.032), raising the possibility of multiple invasion sources. Multiple introductions from a combination of Black Sea and native region sources could be facilitated by intense local and transcontinental shipping activity, respectively.
Displacement of centre of mass during quiet standing assessed using accelerometry in older fallers and non-fallers

Postural sway during quiet standing is associated with falls risk in older adults. The aim of this study was to investigate the utility of a range of accelerometer-derived parameters of centre of mass (COM) displacement in identifying older adults at risk of falling. A series of instrumented standing balance trials were performed to investigate postural control in a group of older adults, categorised as fallers or non-fallers. During each trial, participants were asked to stand as still as possible under two conditions: comfortable stance (six repetitions) and semi-tandem stance (three repetitions). A tri-axial accelerometer was secured to the lower back during the trials. Accelerometer data were twice integrated to estimate COM displacement during the trials, with numerical techniques used to reduce integration error. Anterior-posterior (AP) and medial-lateral (ML) sway range, sway length and sway velocity were examined, along with root mean squared (RMS) acceleration. All derived parameters significantly discriminated fallers from non-fallers during both comfortable and semi-tandem stance. Results indicate that these accelerometer-based estimates of COM displacement may improve the discriminative power of quiet standing falls risk assessments, with potential for use in unsupervised balance assessment.
Is chiropractic evidence based? A pilot study.

OBJECTIVE To calculate the proportion of care delivered in a chiropractic practice supported by good-quality clinical trials. DESIGN Retrospective survey. METHODS Data were collected from patient files relating to 180 consecutive patient visits in a suburban chiropractic practice in northern Spain. Each patient's presenting complaint was paired with the chiropractor's chosen primary intervention. Based on a literature review (Medline, Mantis, and nonautomated searches of local medical libraries), each presenting complaint-primary intervention pairing was categorized according to the level of supporting evidence as follows: Category I, intervention based on good quality clinical trial evidence; Category II, intervention based on poor-quality or no clinical trial evidence. To distinguish between good- and poor-quality clinical trials, studies were critically appraised and assigned quality scores. RESULTS Of the 180 cases surveyed, 123 (68.3%) (95% CI, 61.5%-75.1%) were based on clinical trials of good methodologic quality (Category I). Only 57 (31.7%) (95% CI, 24.9%-38.5%) of the cases were based on poor-quality or no clinical trial evidence (Category II). CONCLUSIONS When patients were used as the denominator, the majority of cases in a chiropractic practice were cared for with interventions based on evidence from good-quality, randomized clinical trials. When compared to the many other studies of similar design that have evaluated the extent to which different medical specialties are evidence based, chiropractic practice was found to have the highest proportion of care (68.3%) supported by good-quality experimental evidence.