Miracle-dz/UniFAR-FTUs huggingface dataset:
TuneGraph, an online visual tool for exploring melodic similarity

This paper presents TuneGraph, an online visual tool for exploring melodic similarity. The underlying data comes from a large index of online music, all transcribed in abc notation, and TuneGraph uses a melodic similarity metric to derive a proximity graph representing similarities within the index. A rich but dense graph is built and then sparsfied weak, non-essential edges. From this a local graph is extracted for each vertex, aimed at indicating close variants of, and similar melodies to, the underlying tune represented by the vertex. Finally an interactive user interface displays each local graph on that tune's webpage, allowing the user to explore melodically similar tunes.
Should psychiatrists be prescribing oestrogen therapy to their female patients?

Summary Some studies have indicated that oestrogen therapy may be beneficial in the treatment of a number of neuropsychiatric disorders. However, it has been suggested that psychiatrists fail to prescribe oestrogen therapy to their patients, as they are ‘not aware of or ‘do not believe’ studies supporting their use. This paper reappraises the putative role of hormone treatments, particularly oestrogen therapy, in psychiatry.
Primary Hyperoxaluria Type 1 in 18 Children: Genotyping and Outcome

Background. Primary hyperoxaluria belongs to a group of rare metabolic disorders with autosomal recessive inheritance. It results from genetic mutations of the AGXT gene, which is more common due to higher consanguinity rates in the developing countries. Clinical features at presentation are heterogeneous even in children from the same family; this study was conducted to determine the clinical characteristics, type of AGXT mutation, and outcome in children diagnosed with PH1 at a tertiary referral center in Oman. Method. Retrospective review of children diagnosed with PH1 at a tertiary hospital in Oman from 2000 to 2013. Result. Total of 18 children were identified. Females composed 61% of the children with median presentation age of 7 months. Severe renal failure was initial presentation in 39% and 22% presented with nephrocalcinosis and/or renal calculi. Family screening diagnosed 39% of patients. Fifty percent of the children underwent hemodialysis. 28% of children underwent organ transplantation. The most common mutation found in Omani children was c.33-34insC mutation in the AGXT gene. Conclusion. Due to consanguinity, PH1 is a common cause of ESRD in Omani children. Genetic testing is recommended to help in family counseling and helps in decreasing the incidence and disease burden; it also could be utilized for premarital screening.
Moods as ups and downs of the motivation pendulum: revisiting reinforcement sensitivity theory (RST) in bipolar disorder

Motivation is a key neurobehavioral concept underlying adaptive responses to environmental incentives and threats. As such, dysregulation of motivational processes may be critical in the formation of abnormal behavioral patterns/tendencies. According to the long standing model of the Reinforcement Sensitivity Theory (RST), motivation behaviors are driven by three neurobehavioral systems mediating the sensitivity to punishment, reward or goal-conflict. Corresponding to current neurobehavioral theories in psychiatry, this theory links abnormal motivational drives to abnormal behavior; viewing depression and mania as two abnormal extremes of reward driven processes leading to either under or over approach tendencies, respectively. We revisit the RST framework in the context of bipolar disorder (BD) and challenge this concept by suggesting that dysregulated interactions of both punishment and reward related processes better account for the psychological and neural abnormalities observed in BD. We further present an integrative model positing that the three parallel motivation systems currently proposed by the RST model, can be viewed as subsystems in a large-scale neurobehavioral network of motivational decision making.
HFE C282Y Homozygosity Is Associated With Lower Total and Low-Density Lipoprotein Cholesterol: The Hemochromatosis and Iron Overload Screening Study

Background—Previous studies have suggested a positive association of coronary heart disease risk and both serum ferritin concentrations and C282Y heterozygosity. Relationships between serum lipids, C282Y homozygosity, and serum ferritin have not been well established. Methods and Results—The Hemochromatosis and Iron Overload Screening study screened 101 168 participants in primary care from 5 field centers in the United States and Canada with serum ferritin, transferrin saturation, and HFE genotyping for C282Y and H63D mutations. Serum lipids were measured in a subset of 176 C282Y homozygotes (63 male, 113 female whites) without a prior diagnosis of, family history, or treatment for hemochromatosis and a matched sample of participants with normal transferrin saturation and serum ferritin without C282Y or H63D mutations (wild-type, 123 male, 189 female whites). The proportion of subjects who reported using prescription cholesterol-lowering medications was ≈3 times higher in HFE wild-type subjects than C282Y homozygotes among men (22% versus 7%; P=0.02) and, in women, 2 times higher (16% versus 8%; P=0.07). After excluding subjects taking cholesterol medications, C282Y homozygotes had significantly lower mean total and low-density lipoprotein cholesterol concentrations than wild-type subjects, with larger genotypic differences for low-density lipoprotein in men (−0.62 mmol/L; 95% CI, −0.93 to −0.33) than in women (−0.28 mmol/L; 95%, CI −0.52 to −0.08). Conclusions—Total mean serum cholesterol and low-density lipoprotein levels were lower in C282Y homozygotes than in HFE wild-type participants. Further studies are required to determine whether this is related to iron overload, HFE alleles, or other factors on C282Y-positive chromosome 6p haplotypes.
The Spinal Accessory Nerve for Functional Muscle Innervation in Facial Reanimation Surgery: An Anatomical and Histomorphometric Study

IntroductionFacial reanimation surgery is performed in severe cases of facial palsy to restore facial function. In a 1-stage procedure, the spinal accessory nerve can be used as a donor nerve to power a free gracilis muscle transplant for the reanimation of the mouth. The aim of this study was to describe the surgical anatomy of the spinal accessory nerve, provide a guide for reliable donor nerve dissection, and analyze the available donor axon counts. MethodsDissections were performed on 10 nonembalmed cadavers (measurements of 20 nerves). Surgical anatomy of the spinal accessory nerve was described and distances to important landmarks were measured. Nerve biopsies were obtained of the main nerve trunk distal to the skull base, caudoposterior to the sternocleidomastoid muscle, proximal to the trapezius muscle and at the level of donor nerve harvest to analyze the myelinated axon count throughout the course of the spinal accessory nerve. The donor nerve length and available donor nerve axon count were the primary outcome parameters in this study. ResultsThe mean donor nerve length was 11.6 cm. The spinal accessory nerve was transferred to the mandibular angle without tension for ideal coaptation to the free muscle transplant. After retraction of the trapezius muscle, a small distal nerve branch that leaves the main nerve trunk at a 90-degree angle medially was used as a landmark to indicate the level of donor nerve transection. On average, 1400 myelinated donor axons were available for innervation of the gracilis muscle transplant. ConclusionsThis study gives a practical guide for spinal accessory nerve dissection for its application in facial reanimation as a motor source for the innervation of a free muscle transplant.
Differential use of the nicotinic receptor by rabies virus based upon substrate origin

To determine the role that the neuronal nicotinic acetylcholine receptor plays in the adsorption process of rabies virus (RV), adult dorsal root ganglion dissociated cultures were exposed to nicotinic agonists before being inoculated. The fixed strain of RV Challenge Virus Standard-11 (CVS-11) was used after being passaged in two different ways, in baby hamster kidney (BHK) cells and in adult mouse brain (MB). Carbachol and nicotine reduced the percentage of CVS-MB infected neurons, yet none of the agonists tested changed the proportion of CVS-BHK infected neurons. This result suggests that the RV phenotype changes depending on its replication environment and neuronal nicotinic acetylcholine receptors are preferentially used for infection by RV strains adapted to adult mouse brain but not to fibroblasts.
Uptake of serum‐opsonized Francisella tularensis by macrophages can be mediated by class A scavenger receptors

The bacterium Francisella tularensis is highly infective, and this is one of the chief attributes that has led to its development as a bioweapon. Establishment of infection requires efficient uptake of F. tularensis by host macrophages, which provide a safe in vivo environment for F. tularensis replication. Little is known, however, about the cellular entry mechanisms employed by this organism. This report shows that efficient uptake of F. tularensis live vaccine strain (LVS) by macrophages is dependent on a heat‐sensitive serum component and is mediated in part by types I and II class A scavenger receptors (SRA), demonstrating for the first time that SRA can act as a receptor for opsonized pathogens. Specifically, uptake of serum‐opsonized LVS was partially blocked by general scavenger receptor inhibitors [fucoidan and poly(I)] and was largely inhibited by a specific function‐blocking antibody against SRA. A role for SRA in LVS binding was confirmed by showing that ectopic expression of SRA in human embryonic kidney cells conferred the capacity for robust serum‐dependent LVS binding. Finally, SRA–/– macrophages ingested significantly fewer LVS than did macrophages from wild‐type mice. These findings support a novel role for SRA in innate immunity and suggest a potential therapeutic approach for modulating F. tularensis infection, namely, blocking SRA as a means of hindering F. tularensis access to its intracellular niche.
Effect of Carbon Nanotubes on the Mechanical Properties of Polypropylene/Wood Flour Composites: Reinforcement Mechanism

Maleic anhydride grafted polypropylene (PP-g-MA) was employed as the compatibilizer and carbon nanotubes (CNTs) or hydroxylated CNTs as reinforcements for polypropylene/wood flour composites. The results showed that when the PP-g-MA loading level was 10 wt%, the bending strength, tensile strength, Izod notched impact strength, and elongation at break of PP-wood composites were enhanced by 85% (66.3 MPa), 93% (33.7 MPa), 5.8% (2.01 kJ/m2), and 64% (23%), respectively, relative to the uncompatibilized composites. The introduction of pristine CNTs only improved slightly the overall mechanical properties of the compatibilized composites due to poor interfacial compatibility. Unlike CNTs, incorporating hydroxylated CNTs (CNT-OH) could significantly improve all of the mechanical properties; for instance, at 0.5 wt% CNT-OH loading, the flexural strength and tensile strength reached 68.5 MPa, and 40.4 MPa about 6.6% higher than that for the composites with the same CNT loading. Furthermore, CNT-OH also remarkably enhanced the storage modulus. Contact angle and morphology observations indicated that the increases in mechanical properties could be attributed to the improvements of interfacial interactions and adhesions of CNTs with the matrix and fillers.
Vascular wall resident progenitor cells: a source for postnatal vasculogenesis

Here, we report the existence of endothelial precursor (EPC) and stem cells in a distinct zone of the vascular wall that are capable to differentiate into mature endothelial cells, hematopoietic and local immune cells, such as macrophages. This zone has been identified to be localized between smooth muscle and adventitial layer of human adult vascular wall. It predominantly contains CD34-positive (+) but CD31-negative (-) cells, which also express VEGFR2 and TIE2. Only few cells in this zone of the vascular wall are positive for CD45. In a ring assay using the fragments of human internal thoracic artery (HITA), we show here that the CD34+ cells of the HITA-wall form capillary sprouts ex vivo and are apparently recruited for capillary formation by tumor cells. New vessels formed by these vascular wall resident EPCs express markers for angiogenically activated endothelial cells, such as CEACAM1, and also for mature endothelial cells, such as VE-cadherin or occludin. Vascular wall areas containing EPCs are found in large and middle sized arteries and veins of all organs studied here. These data suggest the existence of a `vasculogenic zone' in the wall of adult human blood vessels, which may serve as a source for progenitor cells for postnatal vasculogenesis, contributing to tumor vascularization and local immune response.
Mining search engine query logs via suggestion sampling

Many search engines and other web applications suggest auto-completions as the user types in a query. The suggestions are generated from hidden underlying databases, such as query logs, directories, and lexicons. These databases consist of interesting and useful information, but they are typically not directly accessible. In this paper we describe two algorithms for sampling suggestions using only the public suggestion interface. One of the algorithms samples suggestions uniformly at random and the other samples suggestions proportionally to their popularity. These algorithms can be used to mine the hidden suggestion databases. Example applications include comparison of popularity of given keywords within a search engine's query log, estimation of the volume of commercially-oriented queries in a query log, and evaluation of the extent to which a search engine exposes its users to negative content. Our algorithms employ Monte Carlo methods in order to obtain unbiased samples from the suggestion database. Empirical analysis using a publicly available query log demonstrates that our algorithms are efficient and accurate. Results of experiments on two major suggestion services are also provided.
Plastic parasites: sophisticated strategies for survival and reproduction?

Adaptive phenotypic plasticity in life history traits, behaviours, and strategies is ubiquitous in biological systems. It is driven by variation in selection pressures across environmental gradients and operates under constraints imposed by trade‐offs. Phenotypic plasticity has been thoroughly documented for multicellular taxa, such as insects, birds and mammals, and in many cases the underlying selective pressures are well understood. Whilst unicellular parasites face many of the same selective pressures and trade‐offs, plasticity in their phenotypic traits has been largely overlooked and remains poorly understood. Here, we demonstrate that evolutionary theory, developed to explain variation observed in the life‐history traits of multicellular organisms, can be applied to parasites. Though our message is general – we can expect the life‐histories of all parasites to have evolved phenotypic plasticity – we focus our discussion on malaria parasites. We use an evolutionary framework to explain the trade‐offs that parasites face and how plasticity in their life history traits will be expressed according to changes in their in‐host environment. Testing whether variation in parasites traits is adaptive will provide new and fundamental insights into the basic biology of parasites, their epidemiology and the processes of disease during individual infections.
Use of second-site homologous recombination to demonstrate that Epstein-Barr virus nuclear protein 3B is not important for lymphocyte infection or growth transformation in vitro

Recombinant Epstein-Barr viruses with a stop codon inserted into the nuclear protein 3B (EBNA 3B) open reading frame were generated by second-site homologous recombination. These mutant viruses infected and growth transformed primary B lymphocytes, resulting in the establishment of lymphoblastoid cell lines (LCLs). Polymerase chain reaction analysis and Southern hybridizations with infected cell DNA demonstrated the presence of the mutant EBNA 3B and the absence of wild-type EBNA 3B. Immunoblot analysis of the LCLs with affinity-purified EBNA 3B antibodies confirmed the absence of EBNA 3B cross-reactive protein. Virus was reactivated from two of these infected LCLs and serially passaged through primary B lymphocytes. The newly infected cells contained only the mutant recombinant virus. No difference was noted between mutant and wild-type recombinants, derived in parallel, in latent (other than EBNA 3B) or lytic cycle-infected cell virus protein expression or in the growth of the latently infected transformed cell lines. These data indicate that the EBNA 3B protein is not critical for primary B-lymphocyte infection, growth transformation, or lytic virus infection in vitro.
Mobility and traffic analyses in three-dimensional PCS environments

We need to solve various mobility/traffic problems in one-dimensional (1-D), two-dimensional (2-D), and three-dimensional (3-D) micro or picocell environments to efficiently plan future personal communications services (PCS). However, mobility/traffic problems have thus far primarily been studied in 1-D and 2-D cell structures. We extend the previous mobility modeling from 1-D or 2-D space to 3-D unbounded indoor building environments having staircase regions by analytically modeling the mobility to estimate the number of handoffs. We also characterize the blocking probability of each cell according to the mobility by predicting the equivalent input traffic per cell. Based on the blocking probability model, we obtain the required number of channels per cell under the given blocking probability constraint. For example, 13 channels per cell are required to be assigned in order to meet the requirement that the blocking probability does not exceed 0.02 in the case where the number of radio ports (RPs) (cells) is four and 180 users are moving with a mean velocity of 2 km/h (horizontal motion) and 2/3 km/h (vertical motion) on each floor. The computer simulation results are also close to the analytical ones. These results can be utilized in the network planning of future PCS.
TiO2 thin film growth using the MOCVD method

Titanium oxide (TiO2) thin films were obtained using the MOCVD method. In this report we discuss the properties of a film, produced using a ordinary deposition apparatus, as a function of the deposition time, with constant deposition temperature (90 °C), oxygen flow (7,0 L/min) and substrate temperature (400 °C). The films were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), atomic force microscopy (AFM) and visible and ultra-violet region spectroscopy (UV-Vis). The films deposited on Si (100) substrates showed the anatase polycrystalline phase, while the films grown on glass substrates showed no crystallinity. Film thickness increased with deposition time as expected, while the transmittance varied from 72 to 91% and the refractive index remained close to 2.6.
Combination Load Balancing for Video-on-Demand Systems

We observe that an effect of ldquodisk resource sharingrdquo of multi-copy movie traffic has great impact on the blocking performance of a video-on-demand system. This observation leads us to establish a conjecture on how to balance the movie traffic load among ldquocombinationrdquo groups of disks to maximize the level of disk resource sharing. For a given file replication instance, the conjecture predicts in general an effective lower bound on the blocking performance of the system. It motivates the design of a numerical index that measures quantitatively the goodness of disk resource sharing on allocation of multi-copy movie files. It also motivates the design of a greedy file allocation method that decides a good quality heuristic solution for each feasible file replication instance. We further develop analytical formulas to obtain approximate results for the bound fast and accurately. These techniques can be utilized by an optimization program to find near-optimal file assignment solutions for the system computationally efficiently.
A Technique for Separating the Gravitational Torques of Bars and Spirals in Disk Galaxies

We describe a Fourier-based method of separating bars from spirals in near-infrared images. The method takes advantage of the fact that a bar is typically a feature with a relatively fixed position angle and uses the simple assumption that the relative Fourier amplitudes due to the bar decline with radius past a maximum in the same or a similar manner as they rose to that maximum. With such an assumption, the bar can be extrapolated into the spiral region and removed from an image, leaving just the spiral and the axisymmetric background disk light. We refer to such a bar-subtracted image as the "spiral plus disk" image. The axisymmetric background (Fourier index m = 0 image) can then be added back to the bar image to give the "bar plus disk" image. The procedure allows us to estimate the maximum gravitational torque per unit mass per unit square of the circular speed for the bar and spiral forcing separately, parameters that quantitatively define the bar strength Qb and the spiral strength Qs following the recent study of Buta & Block. For the first time, we are able to measure the torques generated by spiral arms alone, and we can now define spiral torque classes, in the same manner as bar torque classes are delineated. We outline the complete procedure here using a 2.1 μm image of NGC 6951, a prototypical SAB(rs)bc spiral having an absolute blue magnitude of -21 and a maximum rotation velocity of 230 km s-1. Comparison between a rotation curve predicted from the m = 0 near-infrared light distribution and an observed rotation curve suggests that NGC 6951 is maximum disk in its bar and main spiral region, implying that our assumption of a constant mass-to-light ratio in our analysis is probably reliable. We justify our assumption on how to make the bar extrapolation using an analysis of NGC 4394, a barred spiral with only weak near-infrared spiral structure, and we justify the number of needed Fourier terms using NGC 1530, one of the most strongly barred galaxies (bar class 7) known. We also evaluate the main uncertainties in the technique. Allowing for uncertainties in vertical scale height, bar extrapolation, sky subtraction, orientation parameters, and the asymmetry in the spiral arms themselves, we estimate Qb = 0.28 ± 0.04 and Qs = 0.21 ± 0.06 for NGC 6951.
Comparison of the Effects of Acarbose and TZQ-F, a New Kind of Traditional Chinese Medicine to Treat Diabetes, Chinese Healthy Volunteers

Ethnopharmacological Relevance. TZQ-F has been traditionally used in Traditional Chinese Medicine as a formula for the treatment of diabetes. Aim of the Study. This study aims to compare the pharmacologic effects and gastrointestinal adverse events between TZQ-F and acarbose. Methods. The double-blind randomized placebo-controlled fivefold crossover study was performed in 20 healthy male volunteers. Plasma glucose, plasma IRI, and plasma C-peptide were measured to assess the pharmacologic effects. Flatus and bowel activity were measured to assess the adverse event of gastrointestinal effect. Results. 3 and 4 tablets of TZQ decreased the C max of plasma glucose compared with that of the previous day and with placebo. 3 tablets also decreased C max of plasma C-peptide compared with placebo. 4 tablets increased C max of plasma insulin after breakfast and the AUC of plasma C-peptide after breakfast and dinner. 2 tablets did not decrease plasma glucose and elevated the C max and AUC of C-peptide after breakfast and dinner, respectively. Acarbose 50 mg decreased the C max of plasma insulin and C-peptide after breakfast and the C max of plasma glucose and C-peptide after dinner. The subjects who received TZQ did not report any abdominal adverse events. Conclusions. 3 tablets of TZQ have the same effects as the acarbose.