Miracle-dz/UniFAR-FTUs huggingface dataset:
Acetylcholinesterase Inhibitors Assay Using Colorimetric pH Sensitive Strips and Image Analysis by a Smartphone

Smartphones are widely spread and their usage does not require any trained personnel. Recently, smartphones were successfully used in analytical chemistry as a simple detection tool in some applications. This paper focuses on immobilization of acetylcholinesterase (AChE) onto commercially available pH strips with stabilization in the gelatin membrane. AChE degrades acetylcholine into choline and acetic acid which causes color change of acid-base indicator. Smartphone served as a tool for measurement of indicator color change from red to orange while inhibitors blocked this process. AChE inhibitors were measured with limits of detection, 149 nM and 22.3 nM for galanthamine and donepezil, respectively. Organic solvents were measured for method interferences. Measurement procedure was performed on 3D printed holder and digital photography was evaluated using red-green-blue (RGB) channels. The invented assay was validated to the standard Ellman's test and verified on murine plasma samples spiked with inhibitors. We consider that the assay is fully suitable for practical performance.
Multiview random forest of local experts combining RGB and LIDAR data for pedestrian detection

Despite recent significant advances, pedestrian detection continues to be an extremely challenging problem in real scenarios. In order to develop a detector that successfully operates under these conditions, it becomes critical to leverage upon multiple cues, multiple imaging modalities and a strong multi-view classifier that accounts for different pedestrian views and poses. In this paper we provide an extensive evaluation that gives insight into how each of these aspects (multi-cue, multi-modality and strong multi-view classifier) affect performance both individually and when integrated together. In the multi-modality component we explore the fusion of RGB and depth maps obtained by high-definition LIDAR, a type of modality that is only recently starting to receive attention. As our analysis reveals, although all the aforementioned aspects significantly help in improving the performance, the fusion of visible spectrum and depth information allows to boost the accuracy by a much larger margin. The resulting detector not only ranks among the top best performers in the challenging KITTI benchmark, but it is built upon very simple blocks that are easy to implement and computationally efficient. These simple blocks can be easily replaced with more sophisticated ones recently proposed, such as the use of convolutional neural networks for feature representation, to further improve the accuracy.
A Procedure to Measure the in-Situ Hygrothermal Behavior of Earth Walls

Rammed earth is a sustainable material with low embodied energy. However, its development as a building material requires a better evaluation of its moisture-thermal buffering abilities and its mechanical behavior. Both of these properties are known to strongly depend on the amount of water contained in wall pores and its evolution. Thus the aim of this paper is to present a procedure to measure this key parameter in rammed earth or cob walls by using two types of probes operating on the Time Domain Reflectometry (TDR) principle. A calibration procedure for the probes requiring solely four parameters is described. This calibration procedure is then used to monitor the hygrothermal behavior of a rammed earth wall (1.5 m × 1 m × 0.5 m), instrumented by six probes during its manufacture, and submitted to insulated, natural convection and forced convection conditions. These measurements underline the robustness of the calibration procedure over a large range of water content, even if the wall is submitted to quite important temperature variations. They also emphasize the importance of gravity on water content heterogeneity when the saturation is high, as well as the role of liquid-to-vapor phase change on the thermal behavior.
Analysing visits to English museums 1850–2015: a research note

ABSTRACT Understanding why people visit museums is of interest to both cultural economics and museum studies. Most existing research relies on survey data concerned with visitors, their immediate background, and their experience of a particular museum. Very few studies have taken a more general perspective and analysed macro-level societal factors, such as inflation, educational attainment and unemployment, and their influence on the number of visits to museums. The conventional approach relies on visitor surveys to understand what drives visits and people’s general views on museums. In a departure from these conventional approaches, this article presents a macro-level approach, using a unique dataset of visit counts for 40 English museums and visitor attractions spanning the period 1850–2015. It examines the effect of socio-economic factors on visits using panel data analysis and macro-level variables. The results suggest that inflation rates, average earnings, and educational level (using the indicator of secondary school attendance) all significantly influence the number of visits made. However, the most important variable is the number of visits recorded for the previous year. These findings are discussed in relation to existing studies, and some suggestions for future research are proposed.
Minimal surgery for the twisted ischaemic adnexa can preserve ovarian function.

BACKGROUND Recently detorsion has replaced salpingo-oophorectomy as treatment for the twisted ischaemic adnexa. This paper asssess whether the ovary resumes normal function after preservation by detorsion. METHODS The results of detorsion performed between January 1988 and December 2001 were retrospectively analysed. Post-operative complications and subsequent ovarian function were assessed including: ultrasound monitoring of follicular development, adnexal appearance during subsequent surgery, and the outcome of IVF. RESULTS A total of 102 detorsions were performed; 67 by laparoscopy, 35 by laparotomy. No patient developed thromboembolism. Post-operative fever occurred in 15% of patients after laparoscopy and 29% after laparotomy (P < 0.01). Patients were hospitalized for a mean (+/- SD) of 2.1 +/- 1.2 and 7.4 +/- 1.5 days after laparoscopy and laparotomy respectively (P < 0.001). Ultrasound showed normal follicular development in 93 and 91% of patients after detorsion by laparoscopy and laparotomy respectively. At subsequent surgery, the adnexa appeared normal in nine out of nine patients after laparoscopy and in four out of five patients after laparotomy. Four patients of the laparoscopy group and two patients of the laparotomy group underwent subsequent IVF. In all six patients oocytes retrieved from the previously ischaemic ovary were fertilized. CONCLUSIONS Detorsion with adnexal sparing is the treatment of choice for twisted ischaemic adnexa, and preferably performed by laparoscopy.
Enhanced Na(+) channel intermediate inactivation in Brugada syndrome.

Brugada syndrome is an inherited cardiac disease that causes sudden death related to idiopathic ventricular fibrillation in a structurally normal heart. The disease is characterized by ST-segment elevation in the right precordial ECG leads and is frequently accompanied by an apparent right bundle-branch block. The biophysical properties of the SCN5A mutation T1620M associated with Brugada syndrome were examined for defects in intermediate inactivation (I:(M)), a gating process in Na(+) channels with kinetic features intermediate between fast and slow inactivation. Cultured mammalian cells expressing T1620M Na(+) channels in the presence of the human beta(1) subunit exhibit enhanced intermediate inactivation at both 22 degrees C and 32 degrees C compared with wild-type recombinant human heart Na(+) channels (WT-hH1). Our findings support the hypothesis that Brugada syndrome is caused, in part, by functionally reduced Na(+) current in the myocardium due to an increased proportion of Na(+) channels that enter the I:(M) state. This phenomenon may contribute significantly to arrhythmogenesis in patients with Brugada syndrome. The full text of this article is available at http://www.circresaha. org.
Exploring the Occupational Therapy Consultation Process Related to Students with ASD Attending A Regular Classroom

This study explored the occupational therapy consultation process for students on the autistic spectrum attending their regular, local school. Grounded theory, a qualitative research methodology, was used to gather and analyse information to answer the research questions. The purpose of grounded theory is to gain understanding about social processes, in this case the social process taking place as part of occupational therapy consultation in an inclusive education context. Semi-structured interviews were employed to gather data from eight experienced school-based occupational therapists. This study developed a high-level description and conceptual ordering as an initial step towards developing a consultation model. The consultation process described, using occupational therapists’ day to day experience, is grounded within the inclusive education setting in Aotearoa/ New Zealand. Constant comparative analysis of the data revealed three interactive and interdependent processes: Joining Up, Finding A Way and Walking and Talking. These processes often occur simultaneously and have significant influence on each other. A central category or overarching theme has been identified, Working Together, which highlights the collaborative nature of the consultation process. A number of important themes emerged regarding the school environment as a complex practice context, highlighting the variability between different schools and classrooms. A strong ecological approach surfaced as an essential aspect of therapists’ practice. Additionally, the therapists’ interactive reasoning process and the problem solving approach were explored. The study deepened the understanding of reframing as a tool frequently used by consulting therapists within an inclusive education context. This research is significant as the results and key themes have the potential to inform occupational therapy practice within the educational setting and direct attention towards areas requiring further research. Consideration needs to be given to the induction of therapists into this particular field of practice as well as to the specific professional development and support needs of school-based occupational therapists working within a consultative model of service delivery.
A Survey on Time-aware Business Process Modeling

One key perspective when dealing with Business Process Management (BPM) is time. All business experts agree upon the fact that time is a key resource for each business process within an organisation. Indeed, time managing is an effective cost and error reduction strategy and thus ensures profit maximization for the organisation. As a result, business managers, researchers, and academicians in management are striving to have full-support of temporal aspects in business process management suites. Consequently, modeling and managing temporal requirements in the business process field is becoming a topic of intensive research. This paper presents a survey of the existing approaches to specifying and verifying the temporal perspective in business processes.
Reward Modulation of Hippocampal Subfield Activation during Successful Associative Encoding and Retrieval

Emerging evidence suggests that motivation enhances episodic memory formation through interactions between medial-temporal lobe (MTL) structures and dopaminergic midbrain. In addition, recent theories propose that motivation specifically facilitates hippocampal associative binding processes, resulting in more detailed memories that are readily reinstated from partial input. Here, we used high-resolution fMRI to determine how motivation influences associative encoding and retrieval processes within human MTL subregions and dopaminergic midbrain. Participants intentionally encoded object associations under varying conditions of reward and performed a retrieval task during which studied associations were cued from partial input. Behaviorally, cued recall performance was superior for high-value relative to low-value associations; however, participants differed in the degree to which rewards influenced memory. The magnitude of behavioral reward modulation was associated with reward-related activation changes in dentate gyrus/CA2,3 during encoding and enhanced functional connectivity between dentate gyrus/CA2,3 and dopaminergic midbrain during both the encoding and retrieval phases of the task. These findings suggests that, within the hippocampus, reward-based motivation specifically enhances dentate gyrus/CA2,3 associative encoding mechanisms through interactions with dopaminergic midbrain. Furthermore, within parahippocampal cortex and dopaminergic midbrain regions, activation associated with successful memory formation was modulated by reward across the group. During the retrieval phase, we also observed enhanced activation in hippocampus and dopaminergic midbrain for high-value associations that occurred in the absence of any explicit cues to reward. Collectively, these findings shed light on fundamental mechanisms through which reward impacts associative memory formation and retrieval through facilitation of MTL and ventral tegmental area/substantia nigra processing.
The Majority of H2-M3 Is Retained Intracellularly in a Peptide-Receptive State and Traffics to the Cell Surface in the Presence of N-Formylated Peptides

We used a new monoclonal antibody (mAb 130) to analyze the intracellular trafficking and surface expression of H2-M3, the major histocompatibility complex class Ib molecule that presents N-formylated peptides to cytotoxic T cells. M3 surface expression is undetectable in most cell types due to the paucity of endogenous antigen. M3 is induced on the cell surface by addition of high-affinity N-formylated peptides from mitochondria and listeria. Peptide-induced M3 expression is most efficient on antigen presenting cells. Basal and inducible expression of M3 is transporter associated with antigen processing (TAP)-dependent, distinguishing M3 from the class Ib molecules TL and CD1. Unlike the expression of class Ia molecules and a previously described M3/Ld chimera, surface expression of M3 cannot be rescued by lowered temperature, suggesting that the α3 domain and transmembrane region of M3 may control trafficking. Pulse–chase analysis and use of trafficking inhibitors revealed a pool of empty M3 in the endoplasmic reticulum or early Golgi apparatus. Addition of exogenous peptide allows maturation with kinetics matching those of Dd. The lack of endogenous N-formylated peptide allows discovery of novel pathogen-derived peptides in normal antigen presenting cells. The nonpolymorphic nature of M3 and its ability to present bacterial antigens rapidly and dominantly make it an attractive target for peptide vaccination strategies.
A Principal Components Approach to Cross-Section Dependence in Panels

The use of GLS to deal with cross-section dependence in panels is not feasible where N is large relative to T since the disturbance covariance matrix is rank deficient. Neither is it the appropriate response if the dependence results from omitted global variables or common shocks correlated with the included regressors. These can be proxied by the principal components of the residuals from a baseline regression. It is shown that the OLS estimates from a regression augmented by these principal components are unbiased and consistent using sequential limits for large T, large N. Simulations show that this leads to a substantial reduction in bias even for relatively small T and N panels. An empirical application indicates that the impact of cross section dependence seems to strengthen the case for long run PPP.
Evaluation of Local Spatio-temporal Salient Feature Detectors for Human Action Recognition

Local spatio-temporal salient features are used for a sparse and compact representation of video contents in many computer vision tasks such as human action recognition. To localize these features (i.e., key point detection), existing methods perform either symmetric or asymmetric multi-resolution temporal filtering and use a structural or a motion saliency criteria. In a common discriminative framework for action classification, different saliency criteria of the structured-based detectors and different temporal filters of the motion-based detectors are compared. We have two main observations. (1) The motion-based detectors localize features which are more effective than those of structured-based detectors. (2) The salient motion features detected using an asymmetric temporal filtering performbetter than all other sparse salient detectors and dense sampling. Based on these two observations, we recommend the use of asymmetric motion features for effective sparse video content representation and action recognition.
Coronary heart disease Association between type II secretory phospholipase A 2 plasma concentrations and activity and cardiovascular events in patients with coronary heart disease

CLINICAL RESEARCH Coronary heart disease
Endothelial-like cells differentiated from mesenchymal stem cells attenuate neointimal hyperplasia after vascular injury

The present study investigated the contribution of bone marrow-derived mesenchymal stem cells (BM-MSCs) to neointimal formation, and whether endothelial-like cells (ELCs) differentiated from BM-MSCs could attenuate intimal hyperplasia following vascular injury. BM-MSCs were isolated from rat femurs and tibias and expanded ex vivo. Differentiation into ELCs was induced by cultivation in the presence of 50 ng/ml vascular endothelial growth factor (VEGF). MSCs and ELCs were labeled with BrdU and injected via the femoral vein on the day of a balloon-induced carotid artery injury. Carotid artery morphology and histology were examined using ultrasound biomicroscopy and immunohistochemistry. Flow cytometry analysis measured CD31 and CD34 expression, and immunofluorescence analysis measured von Willebrand factor and VEGF receptor 2 expression in ELCs. Ultrasound biomicroscopy observed a significantly increased intima-media thickness in the phosphate-buffered saline (PBS) and BM-MSCs groups compared with the ELCs group. Intima/media ratios were significantly reduced in the ELCs group compared with the PBS and BM-MSCs groups. At 4 weeks of administration, the cells labeled with BrdU were abundantly located in the adventitial region and neointima. MSCs were able to differentiate into ELCs in vitro. Cell therapy with BM-MSCs was not able to attenuate neointima thickness, however transplantation with ELCs significantly suppressed intimal hyperplasia following vascular injury.
Favoritism and Referee Bias in European Soccer: Evidence from the Spanish League and the UEFA Champions League

In this paper, we test for, and find evidence of, referee bias in favor of home teams in European football using minute-by-minute analysis to control for within-game events. The context for the analysis is Spain's Primera Liga and the Union of European Football Association (UEFA) Champions League. We find that the award of sanctions by Spanish referees in the Champions League are not significantly different to those of the referees from other countries and as such are subject to the same sources of bias. In Primera Liga matches where the crowd is separated from the pitch by running tracks, we find that the probability of the award of a yellow card to the home team is higher and that of the away team is lower compared to matches played at stadia without running tracks. Similar results are found in the Champions League, where efforts are made to hire “neutral” referees. Referee behavior is also influenced by the size of the crowd in attendance.
Linking safety knowledge to safety behaviours: a moderated mediation of supervisor and worker safety attitudes

ABSTRACT The thousands of deaths and disabilities due to workplace accidents and injuries each year emphasize the importance of safety research. Despite occupational safety research that has contributed to identifying antecedents of safety, little is known about why and how safety knowledge leads to safety behaviours and how personal and situational factors interact to promote occupational safety. Using a multilevel, multisource, and time-lagged research design, the present study investigates whether safety knowledge affects safety behaviours through safety attitudes and further tests whether supervisory safety attitudes can impact the strength of these relationships and play a role as moderators of the proposed mediated relationship. Data were collected from workers (N = 177) and supervisors (N = 42) in a construction company in the energy industry at two time points. Results indicate full support for the moderated mediation model, demonstrating that worker safety attitudes partially mediate the relationship between safety knowledge and safety behaviours. Moreover, when supervisors had positive attitudes towards safety, both the direct relationship between worker safety attitudes and safety behaviours and the indirect relationship between safety knowledge and safety behaviours were more positive compared to when supervisors had negative safety attitudes. Theoretical and practical implications for occupational safety are discussed.
Positive psychology interventions for individuals with mental disabilities : literature review

As opposed of pathologizing people, positive psychology mainly focuses on well-being and life-satisfaction and positive psychology interventions (PPI) have been established to foster quality of life in both clinical and non-clinical populations. From previous research it is known that mentally disabled people, providing they receive sufficient support, are capable of experiencing pleasure and to lead a life that satisfies their needs. At the present day, little is known about the potential of PPIs in the context of mental disabilities. Therefore, the present systematic literature review aims at presenting the current state of knowledge about the application of positive psychology in the context of mental disabilities. A systematic literature search have been carried out using the scientific databases Scopus, Web of Science and PsycInfo looking for studies published between 1998 and April 2018 using keywords to identify positive psychology interventions (e.g. (applied) positive psycholog*) especially tailored to mentally disabled individuals (e.g. mental disab*). The analysis of the interventions has been organized around Seligman’s basic elements of well- being (positive emotions, engagement, relationships, meaning and accomplishment), and potential effects have been explored taking account of methodological aspects of the studies. Eleven studies have been reviewed showing that, for instance, experiencing positive emotions, developing goals, strengthening positive and trustful social relationships, and exploring personal achievements and strengths have been central goals of the interventions. For this purpose, various methods and techniques (e.g. mindfulness mediation and telling personal life-stories) have been used. Depending on intervention method type (e.g., life- story), positive psychology interventions were able to significantly enhance well-being. This review shows that positive psychology interventions for people with mental disabilities is a relatively young yet promising subfield. Indeed, few studies available indicate that PPIs can successfully improve well-being and quality of life of individuals with mental disabilities. To further investigate the potential of PPIs to improve wellbeing in the context of mental disabilities, additional RCT studies with practice-based case studies will have to be complemented.