Miracle-dz/UniFAR-FTUs huggingface dataset:
Numerical Simulations of Manipulation of Microparticles by Droplets in Digital Microfluidics

Author(s): Lan, Chuanjin | Advisor(s): Ma, Yanbao | Abstract: Manipulation of microparticles by droplets is a very useful and important technique for many microfluidics applications. Due to the large specific surface necessary for chemical binding and easy recovery from a dispersion, utilization of nanospheres or microspheres has become more and more popular for different medical, biological, and optical applications. The goal of this research is to understand the mechanism for the manipulation of microparticles by droplets. Dissipative particle dynamics (DPD), which is extensively used to model mesoscale flow phenomena, is applied as the numerical tool for this study. A model for solid microparticles is designed to study the interactions among microparticles, liquid droplets, and solid substrates. A spherical shell is used to represent the microparticle, and the shell surface is packed by dense enough beads to avoid undesired penetration of liquid beads into solid microparticles, conserving the momentum automatically. After that, the interaction between a rigid microparticle and a solid substrate is modeled based on contact mechanics, including adhesion forces, normal forces, and friction forces. After the model for microparticles is built, a baseline case simulating the pickup and transport of a hydrophobic microparticle by a droplet is demonstrated and compared with experimental observations. Then, the flow structures within a droplet containing a hydrophobic microparticle are revealed.With this developed numerical tool, parametric studies are conducted to investigate the effect on the manipulation processes (including pickup, transport, and drop off) of a microparticle by droplet sizes, wetting properties of microparticles, and particle-substrate friction coefficients. The increase of droplet size can speed up the transport of microparticles. However, the increase of particle-substrate friction coefficients can lead to drop-off of a hydrophobic microparticle. The mechanism for the drop-off, or delivery, is analyzed by checking the development of the friction force and driving force on the microparticle during the transport process. The critical velocity, defined as the instantaneous velocity of the microparticle right before the occurrence of delivery, is measured, and it is found that the critical velocity is about same for different sizes of droplets. Based on the numerical results, two different designs, namely passive delivery and active delivery, have been demonstrated to be capable of controlling the location for the delivery of single hydrophobic microparticle without any trap design or external field forces. These numerical results provide a fundamental understanding of interactions among the microparticle, the droplet and the substrate to facilitate the optimal experimental design of digital microfluidic system utilizing microparticles.
Luteal phase support with estrogen in addition to progesterone increases pregnancy rates in in vitro fertilization cycles with poor response to gonadotropins

Abstract In this study, our objective was to determine the effect of adding estradiol hemihydrate (E2) to progestin (P) for luteal phase support on pregnancy outcome in in vitro fertilization (IVF) cycles with poor response to gonadotropins. Ninety-five women with poor ovarian response who underwent controlled ovarian hyperstimulation (COH) with gonadotropin releasing hormone (GnRH) agonist or GnRH antagonist plus gonadotropin protocol for IVF were prospectively randomized into three groups of luteal phase support after oocyte retrieval. Group 1 (n = 33) received only intravaginal progesterone gel (Crinone 8% gel). Group 2 (n = 27) and Group 3 (n = 35) received intravaginal progesterone plus oral 2 and 6 mg estradiol hemihydrate, respectively. Main outcome measures were overall and clinical pregnancy rates (PRs) per patient. Serum LH, E2 and P levels at 7th and 14th days of luteal phase were also measured. Overall and clinical PRs were significantly higher in 2 mg E2 + P than P-only group (44% versus 18% and 37% versus 12.1%, respectively). There were no statistically significant differences between 6 mg E2 + P versus P-only and 2 mg E2 + P versus 6 mg E2 + P groups regarding PRs. Addition of 2 mg/day E2 in addition to P for luteal support significantly increase overall and clinical PRs in cycles with poor response to gonadotropins after IVF.
Screening for alcohol misuse and alcohol-related behaviors among combat veterans.

OBJECTIVE The U.S. military conducts health screenings of service members three to six months after they return from combat deployments. This population health program includes a modified version of the Two-Item Conjoint Screen (TICS), which is widely used in primary care to screen for alcohol misuse. Rates of referral in the military for alcohol treatment are very low, and the utility of these screening questions in predicting serious alcohol-related behaviors is unknown. METHODS Anonymous surveys were collected from 6,527 U.S. Army soldiers who were screened three to four months after returning from deployment to Iraq. Positive responses on the TICS alcohol screen were correlated with alcohol-related behaviors. Odds ratios (ORs) were calculated using logistic regression, after adjusting for gender, rank, race, and military component (active or reserve). RESULTS Twenty-seven percent of soldiers screened positive for alcohol misuse. Compared with soldiers who screened negative, those who screened positive were more likely to have recently engaged in the following behaviors: drinking and driving (OR=4.99, 95% confidence interval [CI]=4.31-5.76), riding with a driver who had been drinking (OR=5.87, CI=4.99-6.91), reporting late or missing work because of a hangover (OR=9.24, CI=6.73-12.68), using illicit drugs (OR=4.97, CI=3.68-6.71), being referred to alcohol rehabilitation (OR=7.15, CI=4.84-10.58), and being convicted of driving under the influence (OR=4.84, CI=3.04-7.67). CONCLUSIONS Positive responses to a two-item alcohol screening tool were strongly associated with serious alcohol-related behaviors. This study highlights the need to improve screening and access to care for alcohol-related problems among service members returning from combat deployments.
Exact solution of two collinear cracks normal to the boundaries of a 1D layered hexagonal piezoelectric quasicrystal

The electroelastic problem related to two collinear cracks of equal length and normal to the boundaries of a one-dimensional hexagonal piezoelectric quasicrystal layer is analysed. By using the finite Fourier transform, a mixed boundary value problem is solved when antiplane mechanical loading and inplane electric loading are applied. The problem is reduce to triple series equations, which are then transformed to a singular integral equation. For uniform remote loading, an exact solution is obtained in closed form, and explicit expressions for the electroelastic field are determined. The intensity factors of the electroelastic field and the energy release rate at the inner and outer crack tips are given and presented graphically.
A Transition to E-Mentoring: Factors That Influence Nurse Engagement

E-mentoring is a form of mentoring that uses the Internet to remove the boundaries of traditional mentoring. Instead of face-to-face and synchronous communication, interactions between mentor(s) and protégé(s) of e-mentoring relationships are primarily asynchronous. Since there was limited information about nurses and e-mentoring in the literature, this quantitative study was undertaken to explore nurses’ attitudes and the identification of facilitators and constraints that could influence the adoption of e-mentoring. Overall, participants (n = 139) had positive attitudes; there were differences in attitudes between participants who had previously experienced mentoring and those who never had (P < .05). The likely-to-engage group had more positive attitudes and identified more facilitators and fewer constraints than did the indecisive and not-likely groups (P < .001). Age and attitudes had a positive relationship with e-mentoring (P = .01). These findings suggest that e-mentoring can be adopted by nurses of all ages, and despite the constraints identified, the benefits of e-mentoring may outweigh the constraints. Organizations considering the adoption of e-mentoring should encourage nurses with positive attitudes and previous mentoring experience to participate in their endeavors. E-mentoring can address today’s multigenerational nursing workforce and positively influence the mentoring process.
The being a patient effect: negative expectations based on group labeling and corresponding treatment affect patient performance

Abstract Patient studies provide insights into mechanisms underlying diseases and thus represent a cornerstone of clinical research. In this study, we report evidence that differences between patients and controls might partly be based on expectations generated by the patients’ knowledge of being invited and treated as a patient: the Being a Patient effect (BP effect). This finding extends previous neuropsychological reports on diagnosis threat. Participants with mild allergies were addressed either as patients or control subjects in a clinical study. We measured the impact of this group labeling and corresponding instructions on pain perception and cognitive performance. Our results provide evidence that the BP effect can indeed affect physiological and cognitive measures in clinical settings. Importantly, these effects can lead to systematic overestimation of genuine disease effects and should be taken into account when disease effects are investigated. Finally, we propose strategies to avoid or minimize this critical confound.
Controlling the electronic structure of graphene using surface-adsorbate interactions

Hybridization of atomic orbitals in graphene on Ni(111) opens up a large energy gap of ≈2.8eV between nonhybridized states at the K point. Here we use alkali-metal adsorbate to reduce and even eliminate this energy gap, and also identify a new mechanism responsible for decoupling graphene from the Ni substrate without intercalation of atomic species underneath. Using angle-resolved photoemission spectroscopy and density functional theory calculations, we show that the energy gap is reduced to 1.3 eV due to moderate decoupling after adsorption of Na on top of graphene. Calculations confirm that after adsorption of Na, graphene bonding to Ni is much weaker due to a reduced overlap of atomic orbitals, which results from n doping of graphene. Finally, we show that the energy gap is eliminated by strong decoupling resulting in a quasifreestanding graphene, which is achieved by subsequent intercalation of the Na underneath graphene. Furthermore, the ability to partially decouple graphene from a Ni substrate via n doping, with or without intercalation, suggests that the graphene-to-substrate interaction could be controlled dynamically.
Pulmonary , gastrointestinal and urogenital parmacology Renoprotective effect of sitagliptin against hypertensive nephropathy induced by chronic administration of L-NAME in rats : Role of GLP-1 and GLP-1 receptor

The present study was undertaken to assess the possible protective effects of sitagliptin, a dipeptidyl peptidase 4-inhibitor (DPP4), against Nω-nitro-L-arginine methyl ester (L-NAME) induced hypertensive nephropathy in rats. Hypertension was induced in adult rats by administration of L-NAME for 6 weeks. Rats were treated with sitagliptin (10 mg/kg/day or 30 mg/kg/day) for six weeks. Chronic L-NAME administration resulted in depletion of serum nitric oxide (NO) associated with elevation in the mean arterial pressure. When compared with the control group; serum urea, serum creatinine, albuminuria, urinary N-acetyl-ß-D-glucosaminidase (NAG) level and renal tissue malondialdhyde (MDA) content were significantly elevated, while creatinine clearance, serum level of glucagon like peptide-1 (GLP-1) as well as renal tissue superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities were signifcantly decreased in L-NAME treated group. Renal expression of mRNA for eNOS and GLP-1 receptors were reduced in the L-NAME treated group as compared with the control group. Treatment with sitagliptin (10 mg/kg or 30 mg/kg) successfully ameliorated the deleterious effects of LNAME on the all tested parameters. Our study indicates a novel protective effect of sitagliptin against LNAME induced hypertensive nephropathy. An effect which is mediated through, increasing serum level of GLP-1, upregulation of GLP-1 receptors, which in turn, lead to induction of expression eNOS, increased serum NO level, tandem with decreased lipid perodixation and restore the antioxidant defense mechanisms. It is worth mentioning that the effects produced by sitaglipin (30 mg/kg) were superior to the effects obtained by the lower dose. & 2013 Elsevier B.V. All rights reserved.
An Adaptive Power Oscillation Damping Controller by STATCOM with Energy Storage

This paper deals with the design of an adaptive power oscillation damping (POD) controller for a static synchronous compensator (STATCOM) equipped with energy storage. This is achieved using a signal estimation technique based on a modified recursive least square (RLS) algorithm, which allows a fast, selective, and adaptive estimation of the low-frequency electro-mechanical oscillations from locally measured signals during power system disturbances. The proposed method is effective in increasing the damping of the system at the frequencies of interest, also in the case of system parameter uncertainties and at various connection points of the compensator. First, the analysis of the im-pact of active and reactive power injection into the power system will be carried out using a simple two-machine system model. A control strategy that optimizes active and reactive power injection at various connection points of the STATCOM will be derived using the simplified model. Small-signal analysis of the dynamic performance of the proposed control strategy will be carried out. The effectiveness of the proposed control method to provide power oscillation damping irrespective of the connection point of the device and in the presence of system parameter uncertainties will be verified through simulation and experimental results
Efficacy and tolerability of carbamazepine for the treatment of painful diabetic neuropathy in adults: a 12-week, open-label, multicenter study

Objective Anticonvulsants are increasingly being used in the symptomatic management of several neuropathic pain disorders. The present observational study was designed to evaluate the efficacy, tolerability, and quality of life (QoL) of carbamazepine use for 12 weeks in patients with painful diabetic neuropathy, in Pakistan. Methods This was a 12-week, multicenter, open-label, uncontrolled trial in adult type 2 diabetic patients (aged 18–65 years) suffering from clinically confirmed neuropathic pain (Douleur Neuropathique en 4 [DN4] score ≥4). Change in neuropathic pain at week 12 compared with baseline was assessed using the Brief Pain Inventory Scale–Short Form (pain severity score and pain interference score). QoL was determined by the American Chronic Pain Association QoL scale. Safety was assessed based on patient reported adverse events (AEs) and serious AEs. Results Of the total 500 screened patients, 452 enrolled and completed the study. The mean (± standard deviation [SD]) pain interference score decreased from 4.5±2.0 at baseline to 3.1±1.9 at week 12 (P<0.001). The mean (± SD) pain severity score decreased from 5.8±2.0 at baseline to 3.6±2.2 at week 12 (P<0.001). There was a decrease of ≥30% in the pain severity score between visits. The mean (± SD) QoL scale score improved from 5.9±1.6 at baseline to 8.0±1.7 at week 12. A total of ten (2.2%) patients reported AEs during the study period. No patient discontinued the study due to AEs. Conclusion In this real-life experience study, carbamazepine, when prescribed for 12 weeks to adult diabetic patients suffering from neuropathic pain, showed pain-relief effect, with reduced mean pain severity and mean pain interference scores and with improved QoL and good tolerability profile.
On the notion of interestingness in automated mathematical discovery

Abstract We survey five mathematical discovery programs by looking in detail at the discovery processes they illustrate and the success they had. We focus on how they estimate the interestingness of concepts and conjectures and extract some common notions about interestingness in automated mathematical discovery. We detail how empirical evidence is used to give plausibility to conjectures, and the different ways in which a result can be thought of as novel. We also look at the ways in which the programs assess how surprising and complex a conjecture statement is, and the different ways in which the applicability of a concept or conjecture is used. Finally, we note how a user can set tasks for the program to achieve and how this affects the calculation of interestingness. We conclude with some hints on the use of interestingness measures for future developers of discovery programs in mathematics.
Velocity loss as an indicator of neuromuscular fatigue during resistance training.

PURPOSE This study aimed to analyze the acute mechanical and metabolic response to resistance exercise protocols (REP) differing in the number of repetitions (R) performed in each set (S) with respect to the maximum predicted number (P). METHODS Over 21 exercise sessions separated by 48-72 h, 18 strength-trained males (10 in bench press (BP) and 8 in squat (SQ)) performed 1) a progressive test for one-repetition maximum (1RM) and load-velocity profile determination, 2) tests of maximal number of repetitions to failure (12RM, 10RM, 8RM, 6RM, and 4RM), and 3) 15 REP (S × R[P]: 3 × 6[12], 3 × 8[12], 3 × 10[12], 3 × 12[12], 3 × 6[10], 3 × 8[10], 3 × 10[10], 3 × 4[8], 3 × 6[8], 3 × 8[8], 3 × 3[6], 3 × 4[6], 3 × 6[6], 3 × 2[4], 3 × 4[4]), with 5-min interset rests. Kinematic data were registered by a linear velocity transducer. Blood lactate and ammonia were measured before and after exercise. RESULTS Mean repetition velocity loss after three sets, loss of velocity pre-post exercise against the 1-m·s load, and countermovement jump height loss (SQ group) were significant for all REP and were highly correlated to each other (r = 0.91-0.97). Velocity loss was significantly greater for BP compared with SQ and strongly correlated to peak postexercise lactate (r = 0.93-0.97) for both SQ and BP. Unlike lactate, ammonia showed a curvilinear response to loss of velocity, only increasing above resting levels when R was at least two repetitions higher than 50% of P. CONCLUSIONS Velocity loss and metabolic stress clearly differs when manipulating the number of repetitions actually performed in each training set. The high correlations found between mechanical (velocity and countermovement jump height losses) and metabolic (lactate, ammonia) measures of fatigue support the validity of using velocity loss to objectively quantify neuromuscular fatigue during resistance training.
Evaulation of Irritation Potential of Surfactant Mixtures

Irritation potential of sodium laureth sulfate (SLES) alone, and in combination with lauryl glucoside (LG), polysorbate 20 (PS) and cocoamidopropyl betaine (CAPB) was tested in 13 human subjects. Four main and six sub‐formulations were prepared and evaluated. Formulations were applied to the forearm as a 24 h close patch study. Irritation was scored by two different methods using an in vivo clinical protocol based on visual scoring and on the stratum corneum capacitance measurement. Irritation was found to be dose dependent. At 2 mg/patch level ten subjects did not show any skin reaction. At 20 mg/patch level eleven subjects showed a broad range of skin irritation. The highest irritation was observed with the formula that contained SLES, LG, and cocamide DEA together. Among the sub‐formulations, cocamide DEA showed the highest irritation grade. A statistically significant correlation was observed between visual, clinical and corneometer scores. It was concluded that the irritation potential of surfactants was related to the total surfactant concentration, application mode, and the thermodynamic activity of molecules in the solution as well as the chemical structure of the surfactant molecules.
Mutual Partner Violence

This study examines racial/ethnic and sex differences in the prevalence of mutual intimate partner violence (IPV) and mental health symptoms. The authors asked 676 university students in heterosexual relationships if they had experienced IPV, coercive victimization, and/or perpetration as well as symptoms of depression, anxiety, hostility, and somatization. Analyses were conducted separately for female and male respondents in four racial/ethnic groups, totaling eight groups (female and male groups each for African Americans, Asian Americans, Latinos, and European Americans). Men, as compared to women, reported stronger correlations between IPV perpetration and IPV victimization, with Asian American men reporting the highest associations of any group. Additionally, experiencing higher partner and coercive violence was significantly related to increased mental health symptoms for all groups except Asian American men. Taken together, these findings suggest that the majority of couples experience mutual violence that elicits mental health problems for both members of the couple.
The location and rate of dayside reconnection during an interval of southward interplanetary magnetic field

Abstract. Using ionospheric data from the SuperDARN radar network and a DMSP satellite we obtain a comprehensive description of the spatial and temporal pattern of day-side reconnection. During a period of southward interplanetary magnetic field (IMF), the data are used to determine the location of the ionospheric projection of the dayside magnetopause reconnection X-line. From the flow of plasma across the projected X-line, we derive the reconnection rate across 7 h of longitude and estimate it for the total length of the X-line footprint, which was found to be 10 h of longitude. Using the Tsyganenko 96 magnetic field model, the ionospheric data are mapped to the magnetopause, in order to provide an estimate of the extent of the reconnection X-line. This is found to be ~ 38 R E in extent, spanning the whole dayside magnetopause from dawn to dusk flank. Our results are compared with previously reported encounters by the Equator-S and Geotail spacecraft with a reconnecting magnetopause, near the dawn flank, for the same period. The SuperDARN observations allow the satellite data to be set in the context of the whole magnetopause reconnection X-line. The total potential associated with dayside reconnection was ~ 150 kV. The reconnection signatures detected by the Equator-S satellite mapped to a region in the ionosphere showing continuous flow across the polar cap boundary, but the reconnection rate was variable and showed a clear spatial variation, with a distinct minimum at 14:00 magnetic local time which was present throughout the 30-min study period. Key words. Magnetospheric physics (magnetopause, cusp and boundary layers; magnetosphere-ionoshere interactions) – Space plasma physics (magnetic reconnection)