Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect and Counter-effect of Entrepreneurship Education and Social Context on Student’s Intentions : Efectos de la formación y el contexto social sobre las intenciones empresariales de los estudiantes

Our paper presents a full experimentation of a new methodology designed for assessing the Entrepreneurship Teaching Programmes (ETP). The theory of planned behaviour (Ajzen, 1991 and 2002) provides us a very useful framework to analyze and measure how an ETP could influence its participants regarding their entrepreneurial attitudes and intentions. We apply this framework to an experimentation consisting in a 3-daypedagogical process focusing on entrepreneurship with a sample of 275 French students following a Specialised Master in Management at a business school ranked among the top four in France. The results suggest that the ETP could have some strong positive effects for some students, depending on their background and initial perspectives on entrepreneurial intention. At the same time, the ETP could also actually decrease the level of entrepreneurial intention (counter-effects) for other students who have been yet exposed to entrepreneurship. Se presenta una medicion completa de una nueva metodologia disenada para determinar los programas de ensenanza del espiritu emprendedor (ETP,por sus siglas en ingles). La teoria de la conducta prevista (Ajzen, 1991 y 2002) nos proporciona un marco muy util para analizar y para medir como un ETP podria influenciar a sus participantes con respecto a sus actitudes e intenciones emprendedoras. Aplicamos esta herramienta a una muestra de 275 estudiantes franceses que cursan un master especializado en Direccion en una escuela de negocio que se situa entre las cuatro mejores en Francia y, que cursan un seminario de tres dias centrado en el espiritu emprendedor. Los resultados sugieren que el ETP podria tener algunos efectos positivos importantes para algunos estudiantes, dependiendo de su conocimiento y perspectivas iniciales en la intecion emprendedora. Al mismo tiempo, el ETP podria tambien disminuir realmente el nivel de la intecion emprendedora (efecto-contrario) para otros estudiantes.
Harnessing the Social: State, Crisis and (Big) Society

The article analyses the UK government’s plans to create a social investment market. The Big Society as political economy is understood as a response to three aspects of a multi-faceted, global crisis: a crisis of capital accumulation; a crisis of social reproduction; and, a fiscal crisis of the state. While the neoliberal state is retreating from the sphere of social reproduction, further off-loading the costs of social reproduction onto the unwaged realms of the home and the community, it is simultaneously engaging in efforts to enable this terrain of social reproduction to be harnessed for profit. Key to this process are specific government policies, the creation of new financial institutions and instruments and the introduction of the metric of ‘social value’. Policies ostensibly aimed at resolving the crisis in ways that empower local communities actually foster further financialisation and a deepening of capitalist disciplinary logics into the social fabric.
Potential effect of smoking on semen quality through DNA damage and the downregulation of Chk1 in sperm

Previous studies have found that smoking is associated with decreased male fertility via altering the quality of semen. However, the mechanism by which cigarette smoking affects semen quality remains to be fully elucidated. Heavy smoking-induced DNA damage has been reported to correlate with abnormal spermatozoa and male infertility. It has been reported that, in response to DNA damage, activation of the checkpoint kinase 1 (Chk1) facilitates S and G2 checkpoint arrest. The aim of the present study was to investigate the expression levels of Chk1 in sperm cells of smoking and non-smoking men, and to further examine the correlation between DNA fragmentation rates and the expression levels of Chk1 with smoking. The present study was performed on a cohort of 841 smoking men and 287 non-smoking men. In the investigation, sperm concentration, motility, viability, seminal plasma zinc concentration, acrosin activity and sperm DNA fragmentation were examined. The gene and protein expression levels of Chk1 were detected using reverse transcription quantitative-polymerase chain reaction and western blot analyses, respectively. It was observed that the progressive motility of the sperm was significantly decreased in the moderate and heavy smoking groups, whereas no significant changes were observed in the mild smoking group. The sperm in the medium-term smoking group had significantly decreased progressive motility, and the semen concentration, sperm count and progressive motility vitality were markedly decreased in the long-term smoking group. Compared with the non-smoking group, the abnormal head rates in the heavy smoking group and long-term smoking group were significantly increased. The sperm viability and seminal plasma zinc concentration were markedly increased in the smoking group. Increased DNA fragmentation rates were found in the smoking group. The expression of Chk1 was significantly decreased in the smoking group, compared with the non-smoking group. Progressive motility and sperm concentration showed a nonlinear association with the relative mRNA expression of Chk1. However, an inverse association was found between DNA fragmentation rates and the progressive motility and sperm concentration. These data suggested that the decrease of semen quality caused by cigarette smoking was not only correlated with sperm DNA fragmentation rates, but was also correlated with a decline in the expressive level of Chk1. The expression of Chk1 was associated with DNA damage and apoptosis, the reduction of which may lead to decreased sperm repair and increased sperm apoptosis, with a subsequent effect on semen quality.
A Randomized Rounding Approach to the Traveling Salesman Problem

For some positive constant \eps_0, we give a (3/2-\eps_0)-approximation algorithm for the following problem: given a graph G_0=(V,E_0), find the shortest tour that visits every vertex at least once. This is a special case of the metric traveling salesman problem when the underlying metric is defined by shortest path distances in G_0. The result improves on the 3/2-approximation algorithm due to Christofides [C76] for this special case. Similar to Christofides, our algorithm finds a spanning tree whose cost is upper bounded by the optimum, then it finds the minimum cost Eulerian augmentation (or T-join) of that tree. The main difference is in the selection of the spanning tree. Except in certain cases where the solution of LP is nearly integral, we select the spanning tree randomly by sampling from a maximum entropy distribution defined by the linear programming relaxation. Despite the simplicity of the algorithm, the analysis builds on a variety of ideas such as properties of strongly Rayleigh measures from probability theory, graph theoretical results on the structure of near minimum cuts, and the integrality of the T-join polytope from polyhedral theory. Also, as a byproduct of our result, we show new properties of the near minimum cuts of any graph, which may be of independent interest.
Autobiographies : A Window into Teachers ’ Identities as Mathematics Learners

Mathematics autobiographies have the potential to help teachers reflect on their identities as mathematics learners and to understand their role in the development of their students’ mathematics identities. This paper reports on a professional development project for K-2 teachers (n = 41), in which participants were asked to write mathematics autobiographies. Using an adaptation of an existing framework for characterizing teachers’ mathematics stories, we describe the consistencies among the participants’ experiences as mathematics learners and the events that are identified as being the impetus for a transition from a negative to a positive attitude toward mathematics. Implications for both teachers and teacher educators are presented.
Contrasting the Chromosomal Organization of Repetitive DNAs in Two Gryllidae Crickets with Highly Divergent Karyotypes

A large percentage of eukaryotic genomes consist of repetitive DNA that plays an important role in the organization, size and evolution. In the case of crickets, chromosomal variability has been found using classical cytogenetics, but almost no information concerning the organization of their repetitive DNAs is available. To better understand the chromosomal organization and diversification of repetitive DNAs in crickets, we studied the chromosomes of two Gryllidae species with highly divergent karyotypes, i.e., 2n(♂) = 29,X0 (Gryllus assimilis) and 2n = 9, neo-X1X2Y (Eneoptera surinamensis). The analyses were performed using classical cytogenetic techniques, repetitive DNA mapping and genome-size estimation. Conserved characteristics were observed, such as the occurrence of a small number of clusters of rDNAs and U snDNAs, in contrast to the multiple clusters/dispersal of the H3 histone genes. The positions of U2 snDNA and 18S rDNA are also conserved, being intermingled within the largest autosome. The distribution and base-pair composition of the heterochromatin and repetitive DNA pools of these organisms differed, suggesting reorganization. Although the microsatellite arrays had a similar distribution pattern, being dispersed along entire chromosomes, as has been observed in some grasshopper species, a band-like pattern was also observed in the E. surinamensis chromosomes, putatively due to their amplification and clustering. In addition to these differences, the genome of E. surinamensis is approximately 2.5 times larger than that of G. assimilis, which we hypothesize is due to the amplification of repetitive DNAs. Finally, we discuss the possible involvement of repetitive DNAs in the differentiation of the neo-sex chromosomes of E. surinamensis, as has been reported in other eukaryotic groups. This study provided an opportunity to explore the evolutionary dynamics of repetitive DNAs in two non-model species and will contribute to the understanding of chromosomal evolution in a group about which little chromosomal and genomic information is known.
Holocene sea levels and palaeoenvironments, Malay-Thai Peninsula, southeast Asia

Sedimentological and palynological investigations of Great Songkhla Lakes, east coast of the Malay-Thai Peninsula, Southeast Asia, reveal sedimentary sequences rich in palynomorph assemblages dominated by pollen of mangroves and freshwater swamps. Compared with other regions in Southeast Asia the assemblages are of relatively low diversity. Geochronological data indicate that the Great Songkhla Lakes record one of the earliest mangrove environments in Southeast Asia (8420-8190 cal. yr BP), which are subsequently replaced by a freshwater swamp at 7880-7680 cal. yr BP owing to the decline of marine influence. Sea-level observations from Great Songkhla Lakes and other areas of the Malay-Thai Peninsula reveal an upward trend of Holocene relative sea level from a minimum of -22 m at 9700-9250 cal. yr BP to a mid-Holocene high stand of 4850-4450 cal. yr BP, which equates to a rise of c. 5.5 mm/yr. The sea-level fall from the high stand is steady at c. - 1.1 mm/yr. Geophysical modelling shows that hydroisostasy contributes a significant spatial variation to the sea-level signal between some site locations (3-4 m during the mid-Holocene), indicating that it is not correct to construct a single relative sea-level history for the Malay-Thai Peninsula.
A Decade of EEG Theta/Beta Ratio Research in ADHD

Objective: Many EEG studies have reported that ADHD is characterized by elevated Theta/Beta ratio (TBR). In this study we conducted a meta-analysis on the TBR in ADHD. Method: TBR data during Eyes Open from location Cz were analyzed from children/adolescents 6-18 years of age with and without ADHD. Results: Nine studies were identified with a total of 1253 children/adolescents with and 517 without ADHD. The grand-mean effect size (ES) for the 6-13 year-olds was 0.75 and for the 6-18 year-olds was 0.62. However the test for heterogeneity remained significant; therefore these ESs are misleading and considered an overestimation. Post-hoc analysis found a decreasing difference in TBR across years, explained by an increasing TBR for the non-ADHD groups. Conclusion: Excessive TBR cannot be considered a reliable diagnostic measure of ADHD, however a substantial sub-group of ADHD patients do deviate on this measure and TBR has prognostic value in this sub-group, warranting its use as a prognostic measure rather than a diagnostic measure.
Association Between Type 2 Diabetes and Exposure to Persistent Organic Pollutants

OBJECTIVE The prevalence of type 2 diabetes is increasing alarmingly in both developed and developing countries. Recently, exposure to persistent organic pollutants (POPs) has been associated with the prevalence of type 2 diabetes. The purpose of this cross-sectional study is to examine the association between type 2 diabetes and POP exposure in the Helsinki Birth Cohort Study. RESEARCH DESIGN AND METHODS The cohort consists of 8,760 people born in Helsinki during 1934–1944, before the global POP emission peak. In 2003, a clinical examination was performed, including blood sampling for laboratory analyses of serum lipids and POPs. Complete data from the examination were available for 1,988 participants. The concentrations of each POP were categorized into four groups on the basis of percentile intervals, and logistic regression was performed to examine diabetes prevalence across the POP categories, adjusting for sex, age, waist circumference, and mean arterial pressure and using the lowest category as the reference group. RESULTS Among the participants with the highest exposure to oxychlordane, trans-nonachlor, 1,1-dichloro-2,2-bis-(p-chlorophenyl)-ethylene (p,p’-DDE, and polychlorinated biphenyl 153, the risk of type 2 diabetes was 1.64–2.24 times higher than that among individuals with the lowest exposure (Plin = 0.003–0.050, where Plin is the P value for linear trend across POP categories). In the stratified analysis, the associations between type 2 diabetes and oxychlordane and trans-nonachlor remained significant and were strongest among the overweight participants. Exposure to 2,2′,4,4′-tetrabromodiphenyl ether (BDE 47) and 2,2′,4,4′,5,5′-hexabromodiphenyl ether (BDE 153) was not associated with type 2 diabetes. CONCLUSIONS This study confirms the association between type 2 diabetes and adult-only exposure to organochlorine pesticides in a general urban population.
Toward a Methodology of Encounters

I consider how poststructural orientations to thinking about epistemology and ontology have been enriched by feminist materialist readings of quantum physics. In light of these developments, I suggest that greater complexity might involve opening up qualitative research to a methodology of encounters, an array of interruptive, aleatory practices, attending to encounters that are both accidental and on purpose. I show how this approach has informed my work, intervening in habitual analytics involving scholarly critique and inspiring new ways of dealing with and expanding what might be thought of as data in qualitative research. Refusing the repositivation of qualitative research, I believe that what is at stake is more than just the knowledge we make, it’s the worlds we would like to make, the kinds of people we want to be, the kind of work we want to do in the world.
Early signs of gait deviation in Duchenne muscular dystrophy.

BACKGROUND Most analytical studies found in literature only focus on specific aspects of Duchenne muscular dystrophy (DMD) gait and posture (joint range of motion, standing balance, variations of gait spatial-temporal parameters). Some of them analyze single cases and do not provide a comprehensive evaluation of locomotion. There are few studies about DMD gait patterns, most of them concerning small groups of patients, sometimes not homogeneous, in which the clinical manifestations of the next stages of DMD were present. AIM The goal of our study was to analyze the characteristics of gait patterns in early stage patients, when clinical and functional evaluation do not allow to quantify initial walking worsening or to identify the changes adopted to compensate for muscle weakness. SETTING Gait Analysis Laboratory by using a six-camera motion capture system (Vicon, Oxford Metrics, UK), set at a sampling rate of 60 Hz. Subjects were asked to walk barefoot at their usual cadence, along a 10-m walkway, where one force platform (Kistler, Switzerland), embedded in the middle portion of the pathway, measured the foot-ground reaction forces. Retroreflective markers were placed on the subjects according to the protocol described in Davis et al. POPULATION A group of 15 patients aging from 5 to 6.8 years was compared with a similar age control group composed of 9 healthy children. RESULTS Spatial and temporal parameters showed significant differences between the two groups: cadence was increased and step length was decreased significantly in the DMD group. We found a significant increase in the range of anterior-posterior pelvic tilt and in pelvic rotation. In the frontal plane there was a tendency for an increased pelvic obliquity. Dynamic range of motion in sagittal plane showed a significant difference at the ankle, with an increased plantarflexion in swing in the dystrophic patients. Maximum dorsiflexion was reduced in the DMD group. Kinetic analysis showed significant differences in power generation and absorption at the hip joint and at the ankle joint. At knee there was a reduced flexor moment in mid-stance. Ankle showed a reduced dorsiflexor moment in terminal stance and pre-swing with a consequent reduction in the peak-to-peak excursion. CONCLUSION AND CLINICAL REHABILITATION IMPACT It was shown that instrumented gait analysis, being more sensitive than other clinical and functional assessment methods, allowed to quantify the very early modifications characterizing locomotion worsening in the first stage of the DMD.
The Novel Gamma Secretase Inhibitor RO4929097 Reduces the Tumor Initiating Potential of Melanoma

Several reports have demonstrated a role for aberrant NOTCH signaling in melanoma genesis and progression, prompting us to explore if targeting this pathway is a valid therapeutic approach against melanoma. We targeted NOTCH signaling using RO4929097, a novel inhibitor of gamma secretase, which is a key component of the enzymatic complex that cleaves and activates NOTCH. The effects of RO4929097 on the oncogenic and stem cell properties of a panel of melanoma cell lines were tested both in vitro and in vivo, using xenograft models. In human primary melanoma cell lines, RO4929097 decreased the levels of NOTCH transcriptional target HES1. This was accompanied by reduced proliferation and impaired ability to form colonies in soft agar and to organize in tridimensional spheres. Moreover, RO4929097 affected the growth of human primary melanoma xenograft in NOD/SCID/IL2gammaR-/- mice and inhibited subsequent tumor formation in a serial xenotransplantation model, suggesting that inhibition of NOTCH signaling suppresses the tumor initiating potential of melanoma cells. In addition, RO4929097 decreased tumor volume and blocked the invasive growth pattern of metastatic melanoma cell lines in vivo. Finally, increased gene expression of NOTCH signaling components correlated with shorter post recurrence survival in metastatic melanoma cases. Our data support NOTCH inhibition as a promising therapeutic strategy against melanoma.
Folic acid in the prevention of neural tube defects: Awareness among laywomen and healthcare providers in Japan

It is known that neural tube defects are folic acid preventable congenital anomalies. We investigated to what extent this information was disseminated among laywomen and healthcare providers. Questionnaire studies were conducted twice, in 2002 and 2007, for four groups of laywomen and seven groups of healthcare providers in Japan regarding awareness, folic acid supplements and healthy diets. Awareness among laywomen was less than 20%, except for families who had experience with spina bifida in 2002, and 5 years later only pregnant women showed a significant increase in awareness. Awareness among healthcare providers varied from 12 to 76%, depending on their profession, and this proportion increased in five of the seven groups in 2007. The majority of laywomen obtained their information from mass media, while the majority of healthcare providers received information through media for professionals. Laywomen who used folate supplements and healthcare providers who recommended them were initially fewer than 25 and 37%, respectively. Five years later, however, pregnant women who used folic acid supplements increased from 9.1 to 43.1%. As awareness among non‐pregnant laywomen and some healthcare providers is considerably low, information should be presented repeatedly to these groups. The difficulty in getting women to consume folic acid supplements is an argument for the government to require folic acid fortification of grains so that the prevention of neural tube defects can be maximized.
Credibility of the emotional witness: A study of ratings by police investigators

Abstract Credibility judgments by police investigators were examined. Sixty-nine investigators viewed one of three video-recorded versions of a rape victim's statement where the role was played by a professional actress. The statements were given in a free recall manner with identical wording, but differing in the emotions displayed, termed congruent, neutral and incongruent emotional expressions. Results showed that emotions displayed by the rape victim affected police officers’ judgments of credibility. The victim was judged as most credible when crying and showing despair, and less credible when being neutral or expressing more positive emotions. This result indicates stereotypic beliefs about rape victim behavior among police officers, similar to those found for lay persons. Results are discussed in terms of professional expertise.
Glycinergic amacrine cells of the rat retina

Physiological studies of neurons of the inner retina, e.g., of amacrine cells, are now possible in a mammalian retinal slice preparation. The present anatomical study characterizes glycinergic amacrine cells of the rat retina and thus lays the ground for such future physiological and pharmacological experiments. Rat retinae were immunolabeled with antibodies against glycine and the glycine transporter‐1 (GLYT‐1), respectively. Glycine immunoreactivity was found in approximately 50% of the amacrine and 25% of the bipolar cells. GLYT‐1 immunoreactivity was restricted to glycinergic amacrine cells. They were morphologically characterized by the intracellular injection of Lucifer Yellow followed by GLYT‐1 immunolabeling. Eight different types of glycinergic amacrine cells could be distinguished. They were all small‐field amacrine cells with bushy dendritic trees terminating at different levels within the inner plexiform layer. The well‐known AII amacrine cell was encountered most frequently. From our measurements of the dendritic field sizes and the density of glycinergic cells, we estimate that there are enough glycinergic amacrine cells available to make sure that all eight types and possibly more tile the retina regularly with their dendritic fields. J. Comp. Neurol. 401:34–46, 1998. © 1998 Wiley‐Liss, Inc.