Miracle-dz/UniFAR-FTUs huggingface dataset:
Evaluating the safety effects of bicycle lanes in New York City.

OBJECTIVES We evaluated the effects of on-street bicycle lanes installed prior to 2007 on different categories of crashes (total crashes, bicyclist crashes, pedestrian crashes, multiple-vehicle crashes, and injurious or fatal crashes) occurring on roadway segments and at intersections in New York City. METHODS We used generalized estimating equation methodology to compare changes in police-reported crashes in a treatment group and a comparison group before and after installation of bicycle lanes. Our study approach allowed us to control confounding factors, such as built environment characteristics, that cannot typically be controlled when a comparison group is used. RESULTS Installation of bicycle lanes did not lead to an increase in crashes, despite the probable increase in the number of bicyclists. The most likely explanations for the lack of increase in crashes are reduced vehicular speeds and fewer conflicts between vehicles and bicyclists after installation of these lanes. CONCLUSIONS Our results indicate that characteristics of the built environment have a direct impact on crashes and that they should thus be controlled in studies evaluating traffic countermeasures such as bicycle lanes. To prevent crashes at intersections, we recommend installation of "bike boxes" and markings that indicate the path of bicycle lanes across intersections.
Optimizing Cache Performance of the Discrete Wavelet Transform Using a Visualization Tool

The 2D DWT consists of two 1D DWT in both directions: horizontal filtering processes the rows followed by vertical filtering processes the columns. It is well known that a straightforward implementation of the vertical filtering shows quite different performance with various working set sizes. The only reasonable explanation for this has to be the access behavior of the cache memory. As known, vertical filtering has mapping conflicts in the cache with a working set size that is power of two. However, it is not clear how this conflict forms and whether cache problems exist with other data sizes. Such knowledge is the base for efficient code optimization. In order to acquire this knowledge and to achieve more accurate optimization potentials, we apply a cache visualization tool to examine the runtime cache activities of the vertical implementation. We find that besides mapping conflicts, vertical filtering also shows a large number of capacity misses. More specifically, the visualization tool allows us to detect the parameters related to the strategies. This guarantees the feasibility of the optimization. Our initial experimental results on several different architectures show an up to 215% gain in execution time compared to an already optimized baseline implementation.
Role of the Autonomic Nervous System in the Release of Rat Submandibular Gland Kallikrein into the Circulation

We have previously demonstrated that the rat submandibular gland releases immu-noreactive kallikrein into the circulation. To study the role of the autonomic nervous system in this release, submandibular gland blood flow and kallikrein concentration in peripheral arterial and venous blood from the gland were measured and secretion rates calculated before and after parasympathetic and sympathetic nerve stimulation (8V, 2 msec, 10 Hz) for 1 minute. Immunoreac-tive kallikrein in plasma was measured by radioimmunoassay, and timed collections of venous outflow were used to measure blood flow. During basal conditions, the unstimulated submandibular gland of the rat released immunoreactive kallikrein into blood at the rate of 0.92 ± 0.07 ng/min. Parasympathetic stimulation increased blood flow 4-fold (before, 68.5 ± 8.3 μl/min; after, 253.5 ± 76.2; P < 0.05) without significantly changing immunoreactive kallikrein secretion rate. Sympathetic stimulation produced an 11-fold increase in blood flow (before, 64.9 ± 9.3 μl/min; after, 709.6 ± 97.5; P < 0.05) and a 57-fold increase in immunoreactive kallikrein secretion rate from the gland (before, 1.05 ± 0.25 ng/min; after, 59.8 ± 18.6; P < 0.05). Sympathetic stimulation also produced a 4-fold increase in the concentration of immunoreactive glandular kallikrein in arterial plasma (before, 15.2 ± 1.1 ng/ml; after, 56.2 ± 12.9; P < 0.05). Pretreatment with phentolamine (1 mg/kg) or prazosin (0.2 mg/kg) blocked the increase in kallikrein secretion rate produced by sympathetic stimulation. These results indicate that the sympathetic nervous system, through activation of oa-adrenoreceptors, controls kallikrein secretion from the submandibular gland into the circulation. Released kallikrein may be responsible for the reactive vasodilation observed in the rat submandib-ular gland after sympathetic stimulation.
The relative influence of natural selection and geography on gene flow in guppies

Two general processes may influence gene flow among populations. One involves divergent selection, wherein the maladaptation of immigrants and hybrids impedes gene flow between ecological environments (i.e. ecological speciation). The other involves geographic features that limit dispersal. We determined the relative influence of these two processes in natural populations of Trinidadian guppies (Poecilia reticulata). If selection is important, gene flow should be reduced between different selective environments. If geography is important, gene flow should be impeded by geographic distance and physical barriers. We examined how genetic divergence, long‐term gene flow, and contemporary dispersal within a watershed were influenced by waterfalls, geographic distance, predation, and habitat features. We found that waterfalls and geographic distance increased genetic divergence and reduced dispersal and long‐term gene flow. Differences in predation or habitat features did not influence genetic divergence or gene flow. In contrast, differences in predation did appear to reduce contemporary dispersal. We suggest that the standard predictions of ecological speciation may be heavily nuanced by the mating behaviour and life history strategies of guppies.
When do markets with simple agents fail?

We consider (prediction) markets where myopic agents sequentially interact with an automated market maker. We show a broad negative result: by varying the order of participation, the market's aggregate prediction can converge to an arbitrary value. In other words, markets may fail to do any meaningful belief aggregation. On the positive side, we show that under a random participation model, steady state prices equal those of the traditional static prediction market model. We discuss applications of our results to the failure of the 1996 Iowa Electronic Market.
High Prevalence of Self-Reported Undiagnosed HIV despite High Coverage of HIV Testing: A Cross-Sectional Population Based Sero-Survey in South Africa

Objectives To measure HIV prevalence and uptake of HIV counseling and testing (HCT) in a peri-urban South African community. To assess predictors for previous HIV testing and the association between the yield of previously undiagnosed HIV and time of last negative HIV test Methods A random sample of 10% of the adult population (≥15 years) were invited to attend a mobile HCT service. Study procedures included a questionnaire, HIV testing and CD4 counts. Predictors for previous testing were determined using a binominal model. Results 1,144 (88.0%) of 1,300 randomly selected individuals participated in the study. 71.0% (68.3–73.6) had previously had an HIV test and 37.5% (34.6–40.5) had tested in the past 12 months. Men, migrants and older (>35 years) and younger (<20 years) individuals were less likely to have had a previous HIV test. Overall HIV prevalence was 22.7 (20.3–25.3) with peak prevalence of 41.8% (35.8–47.8) in women aged 25.1–35 years and 37.5% (26.7–48.3) in men aged 25.1–45 years. Prevalence of previously undiagnosed HIV was 10.3% (8.5–12.1) overall and 4.5% (2.3–6.6), 8.0% (CI 3.9–12.0) and 20.0% (13.2–26.8) in individuals who had their most recent HIV test within 1, 1–2 and more than 2 years prior to the survey. Conclusion The high burden of undiagnosed HIV in individuals who had recently tested underscores the importance of frequent repeat testing at least annually. The high prevalence of previously undiagnosed HIV in individuals reporting a negative test in the 12 months preceding the survey indicates a very high incidence. Innovative prevention strategies are needed.
Recognizing frontal face images using Hidden Markov models with one training image per person

Recently many important face recognition systems could deal well with frontal view face images. However few of them work well when there is only one training image per person. We propose an approach to cope with the problem by using 1D discrete hidden Markov model (1D-DHMM). The model training and recognition part were carried out on both vertical and horizontal directions. New way of extracting observations and using observation sequences in recognition is introduced. The Haar wavelet transform was applied to the image to lessen the dimension of the observation vectors. Our experiment results tested on the frontal view AR Face Database show that the proposed method outperforms the PCA, LDA, LFA approaches tested on the same database.
The Cytomegalovirus-Specific CD4+ T-Cell Response Expands with Age and Markedly Alters the CD4+ T-Cell Repertoire

ABSTRACT Immune function in the elderly is associated with a number of phenotypic and functional abnormalities, and this phenomenon of immune senescence is associated with increased susceptibility to infection. The immune response to pathogens frequently declines with age, but the CD8+ T-cell response to cytomegalovirus (CMV) is unusual, as it demonstrates a significant expansion over time. Here we have documented the CD4+ T-cell immune response to CMV in healthy donors of different ages. The magnitude of the CMV-specific CD4+ T-cell immune response increases from a mean of 2.2% of the CD4+ T-cell pool in donors below 50 years of age to 4.7% in donors aged over 65 years. In addition, CMV-specific CD4+ T cells in elderly donors demonstrate decreased production of interleukin-2 and less dependence on costimulation. CMV seropositivity is associated with marked changes in the phenotype of the overall CD4+ T-cell repertoire in healthy aged donors, including an increase in CD57+ expression and a decrease in CD28 and CD27 expression, a phenotypic profile characteristic of immune senescence. This memory inflation of CMV-specific CD4+ T cells contributes to evidence that CMV infection may be damaging to immune function in elderly individuals.
Asymptotic Analysis in MIMO MRT/MRC Systems

Through the analysis of the probability density function of the squared largest singular value of a complex Gaussian matrix at the origin and tail, we obtain two asymptotic results related to the multi-input multi-output (MIMO) maximum-ratio-transmission/maximum-ratio-combining (MRT/MRC) systems. One is the asymptotic error performance (in terms of SNR) in a single-user system, and the other is the asymptotic system capacity (in terms of the number of users) in the multiuser scenario when multiuser diversity is exploited. Similar results are also obtained for two other MIMO diversity schemes, space-time block coding and selection combining. Our results reveal a simple connection with system parameters, providing good insights for the design of MIMO diversity systems.
@ Claremont

Using the information systems lifecycle as a unifying framework, we review online communities research and propose a sequence for incorporating success conditions during initiation and development to increase their chances of becoming a successful community, one in which members participate actively and develop lasting relationships. Online communities evolve following distinctive lifecycle stages and recommendations for success are more or less relevant depending on the developmental stage of the online community. In addition, the goal of the online community under study determines the components to include in the development of a successful online community. Online community builders and researchers will beneﬁt from this review of the conditions that help online communities succeed.
Identifying Communication Patterns between Virtual Machines in Software-Defined Data Centers

Modern cloud data centers typically exploit management strategies to reduce the overall energy consumption. While most of the solutions focus on the energy consumption due to computational elements, the advent of the Software-Defined Network paradigm opens the possibility for more complex strategies taking into account the network traffic exchange within the data center. However, a network-aware Virtual Machine (VM) allocation requires the knowledge of data communication patterns, so that VMs exchanging significant amount of data can be placed on the same physical host or on low cost communication paths. In Infrastructure as a Service data centers, the information about VMs traffic exchange is not easily available unless a specialized monitoring function is deployed over the data center infrastructure. The main contribution of this paper is a methodology to infer VMs communication patterns starting from input/output network traffic time series of each VM and without relaying on a special purpose monitoring. Our reference scenario is a software-defined data center hosting a multi-tier application deployed using horizontal replication. The proposed methodology has two main goals to support a network-aware VMs allocation: first, to identify couples of intensively communicating VMs through correlation-based analysis of the time series; second, to identify VMs belonging to the same vertical stack of a multi-tier application. We evaluate the methodology by comparing different correlation indexes, clustering algorithms and time granularities to monitor the network traffic. The experimental results demonstrate the capability of the proposed approach to identify interacting VMs, even in a challenging scenario where the traffic patterns are similar in every VM belonging to the same application tier.
Role of mTOR Downstream Effector Signaling Molecules in Francisella Tularensis Internalization by Murine Macrophages

Francisella tularensis is an infectious, gram-negative, intracellular microorganism, and the cause of tularemia. Invasion of host cells by intracellular pathogens like Francisella is initiated by their interaction with different host cell membrane receptors and the rapid phosphorylation of different downstream signaling molecules. PI3K and Syk have been shown to be involved in F. tularensis host cell entry, and both of these signaling molecules are associated with the master regulator serine/threonine kinase mTOR; yet the involvement of mTOR in F. tularensis invasion of host cells has not been assessed. Here, we report that infection of macrophages with F. tularensis triggers the phosphorylation of mTOR downstream effector molecules, and that signaling via TLR2 is necessary for these events. Inhibition of mTOR or of PI3K, ERK, or p38, but not Akt signaling, downregulates the levels of phosphorylation of mTOR downstream targets, and significantly reduces the number of F. tularensis cells invading macrophages. Moreover, while phosphorylation of mTOR downstream effectors occurs via the PI3K pathway, it also involves PLCγ1 and Ca2+ signaling. Furthermore, abrogation of PLC or Ca2+ signaling revealed their important role in the ability of F. tularensis to invade host cells. Together, these findings suggest that F. tularensis invasion of primary macrophages utilize a myriad of host signaling pathways to ensure effective cell entry.
The pattern of skin diseases in the Qassim region of Saudi Arabia: What the primary care physician should know

Background and Objectives :Epidemiological studies to determine the burden of skin diseases are important for proper health care planning. The purpose of this study was to find the pattern of skin diseases in our patients attending university-affiliated dermatologic clinics in the Qassim region. Methods : We conducted a prospective study of all Saudi patients attending the Qassim University Medical College-affiliated dermatology clinics of the Ministry of Health for a period of 12 months from 1 March 2008 to 28 February 2009. Results : The study included 3051 patients comprising 1786 (58.5%) males and 1265 (41.5%) females. Males outnumbered females (P<.05) (male-to-female ratio, 1.4:1). The mean age (standard error of the mean) of the patients was 25.3 (0.27) years. About 71% of the patients were between 5 and 34 years of age. The top five skin diseases were eczema/ dermatitis (19.5%), viral infections (16.6%), pilosebaceous disorders (14.4%), pigmentary lesions (11.2%) and hair disorders (7.6%). The major disorder in males was viral skin infections (20.0%), while eczema/dermatitis (20.7%) constituted the most prevalent skin disease in females. Seasonal variations were recorded in cases of pigmentary lesions, papulosquamous disorders and protozoal infections. Conclusion : Infectious skin diseases, eczema/dermatitis, pilosebaceous disorders, pigmentary lesions and hair disorders ranked as the top five skin diseases. Appropriate training programs for diagnosing and managing common skin diseases should be initiated for primary health care physicians and other general practitioners so as to decrease referrals to dermatology clinics.
Differences in Leaf Flammability, Leaf Traits and Flammability-Trait Relationships between Native and Exotic Plant Species of Dry Sclerophyll Forest

The flammability of plant leaves influences the spread of fire through vegetation. Exotic plants invading native vegetation may increase the spread of bushfires if their leaves are more flammable than native leaves. We compared fresh-leaf and dry-leaf flammability (time to ignition) between 52 native and 27 exotic plant species inhabiting dry sclerophyll forest. We found that mean time to ignition was significantly faster in dry exotic leaves than in dry native leaves. There was no significant native-exotic difference in mean time to ignition for fresh leaves. The significantly higher fresh-leaf water content that was found in exotics, lost in the conversion from a fresh to dry state, suggests that leaf water provides an important buffering effect that leads to equivalent mean time to ignition in fresh exotic and native leaves. Exotic leaves were also significantly wider, longer and broader in area with significantly higher specific leaf area–but not thicker–than native leaves. We examined scaling relationships between leaf flammability and leaf size (leaf width, length, area, specific leaf area and thickness). While exotics occupied the comparatively larger and more flammable end of the leaf size-flammability spectrum in general, leaf flammability was significantly correlated with all measures of leaf size except leaf thickness in both native and exotic species such that larger leaves were faster to ignite. Our findings for increased flammability linked with larger leaf size in exotics demonstrate that exotic plant species have the potential to increase the spread of bushfires in dry sclerophyll forest.
Proprotein Processing within Secretory Dense Core Granules ofTetrahymena thermophila *

In the ciliate Tetrahymena thermophila, the polypeptides stored in secretory dense core granules (DCGs) are generated by proteolytic processing of precursors, and the mature products assemble as a crystal. Previous observations suggested that this maturation involves precise cleavage at distinct motifs by a small number of enzymes. To test these inferences, we analyzed the determinants for site-specific processing of pro-Grl1p (Granule lattice protein 1) by complete gene replacement with modified alleles. Contrary to the predictions of previous models, none of the component amino acids in a putative processing motif was necessary for targeted cleavage. Indeed, cleavage at a range of alternative positions near the native site was consistent with normal DCG assembly. Furthermore, substitution of other classes of processing site motifs did not perturb DCG structure or function. These results suggest that processing can be catalyzed by multiple proteases, for which substrate accessibility may be the prime determinant of site specificity. Consistent with this, inhibition of either subtilisin or cathepsin family proteases resulted in delayed processing of pro-Grl1p.
Corrosion behaviour and biofouling characteristics of structural steel in the coastal waters of the Gulf of Mannar (Bay of Bengal), India

The corrosion behaviour and biofouling characteristics of structural steel coupons at three different locations in the Gulf of Mannar were studied over a period of 2 years. Oyster fouling was predominant at Tuticorin open sea, while barnacle fouling was more pronounced at Mandapam and Tuticorin harbour. Among the three locations, Tuticorin open sea showed a markedly higher biomass, particularly after 12 and 18 months. The extent of crevice corrosion caused by hard foulers was more pronounced at Tuticorin harbour when compared to that at the other two locations. The corrosion rate of the structural steel coupons for 24 months was in the order, Mandapam > Tuticorin harbor > Tuticorin open sea. The loss in tensile strength at 12 and 24 months was in the order, Tuticorin open sea > Tuticorin harbor > Mandapam. The corrosion behaviour of the structural steel coupons was strongly influenced by the variations in the biofouling assemblage at the three different coastal locations.
Session-Based Admission Control: A Mechanism for Peak Load Management of Commercial Web Sites

We consider a new, session-based workload for measuring web server performance. We define a session as a sequence of client's individual requests. Using a simulation model, we show that an overloaded web server can experience a severe loss of throughput measured as a number of completed sessions compared against the server throughput measured in requests per second. Moreover, statistical analysis of completed sessions reveals that the overloaded web server discriminates against longer sessions. For e-commerce retail sites, longer sessions are typically the ones that would result in purchases, so they are precisely the ones for which the companies want to guarantee completion. To improve Web QoS for commercial Web servers, we introduce a session-based admission control (SBAC) to prevent a web server from becoming overloaded and to ensure that longer sessions can be completed. We show that a Web server augmented with the admission control mechanism is able to provide a fair guarantee of completion, for any accepted session, independent of a session length. This provides a predictable and controllable platform for web applications and is a critical requirement for any e-business. Additionally, we propose two new adaptive admission control strategies, hybrid and predictive, aiming to optimize the performance of SBAC mechanism. These new adaptive strategies are based on a self-tunable admission control function, which adjusts itself accordingly to variations in traffic loads.