Miracle-dz/UniFAR-FTUs huggingface dataset:
Changes in Operational Efficiency and Firm Performance: A Frontier Analysis Approach

This study examines whether changes in operational efficiency predict firm performance. Using measures based on frontier analysis as our proxies for operational efficiency, we find that changes in efficiency are positively associated with changes in current and future earnings. We also find a positive relation between efficiency changes and contemporaneous stock returns, implying that investors find the information in efficiency changes to be value relevant. However, we also show that efficiency changes predict future stock returns, suggesting that market participants do not fully incorporate the predictive power of changes in efficiency for future changes in profitability. Finally, we show that our measures of operational efficiency changes are positively associated with analyst forecast revisions, but not associated with analyst forecast errors; these results suggest that analysts have a deep understanding of firms’ efficiency. Importantly, our results hold even after controlling for fundamental signals and changes in asset turnover, a commonly used proxy for operational efficiency. Overall, our study provides evidence suggesting that measures of operational efficiency derived from frontier analysis have predictive power incremental to simple financial ratios. Results from our study therefore have implications for fundamental analysis.
Coastal hypoxia and sediment biogeochemistry

The intensity, duration and frequency of coastal hypoxia (oxygen concentration <63µM) are increasing due to human alteration of coastal ecosystems and changes in oceanographic conditions due to global warming. Here we provide a concise review of the consequences of coastal hy- poxia for sediment biogeochemistry. Changes in bottom- water oxygen levels have consequences for early diagenetic pathways (more anaerobic at expense of aerobic pathways), the efficiency of re-oxidation of reduced metabolites and the nature, direction and magnitude of sediment-water exchange fluxes. Hypoxia may also lead to more organic matter accu- mulation and burial and the organic matter eventually buried is also of higher quality, i.e. less degraded. Bottom-water oxygen levels also affect the organisms involved in organic matter processing with the contribution of metazoans de- creasing as oxygen levels drop. Hypoxia has a significant effect on benthic animals with the consequences that ecosys- tem functions related to macrofauna such as bio-irrigation and bioturbation are significantly affected by hypoxia as well. Since many microbes and microbial-mediated biogeo- chemical processes depend on animal-induced transport pro- cesses (e.g. re-oxidation of particulate reduced sulphur and denitrification), there are indirect hypoxia effects on biogeo- chemistry via the benthos. Severe long-lasting hypoxia and anoxia may result in the accumulation of reduced compounds in sediments and elimination of macrobenthic communities with the consequences that biogeochemical properties dur- ing trajectories of decreasing and increasing oxygen may be different (hysteresis) with consequences for coastal ecosys- tem dynamics.
Evidence, Education and Practice

Stroke causes greater loss of quality-adjusted life years than any other disease and is also one of the most expensive disorders. The burden of stroke will increase in the future due to change in the age structure of populations. We have a vast body of evidence on how to prevent stroke and how to treat stroke patients. Good examples are treatment of hypertension, antithrombotic agents and carotid surgery in stroke prevention, thrombolysis in ischaemic stroke and stroke unit care for all stroke patients. We only have to translate scientific evidence into daily practice. If some pieces are missing, it is our duty to generate them through research. While taking part in randomized clinical trials (RCTs), the discipline, an essential part of RCTs, will improve the daily care of all stroke patients. Besides RCTs there are many other sources of scientific evidence for stroke management, one of which is the European Stroke Initiative (EUSI). The mission of the EUSI is to improve and optimize stroke management in Europe through education and by offering best practice guidelines. Also national and international societies and organizations play an important role in providing education. The human factor is one obstacle to more successful stroke management because to be more effective we must change our own clinical routine. We can make a difference by applying available evidence to our daily practice.
Trends in alcohol drinking among university students at the Polish University of Warmia and Mazury in Olsztyn

Aim: This article presents cross-sectional data collected from the population of first-year students at the University of Warmia and Mazury in Olsztyn in 2000–2016. The aim of the study was to investigate changes in the following trends among university students after Poland’s accession to the European Union (2004): (1) alcohol consumption, (2) alcoholic beverage preferences, and (3) attitudes towards alcohol. Method: The study relied on data from anonymous surveys conducted every two years between 2000 and 2016 among a representative sample of first-year university students. A total of 9778 individuals (4264 males and 5514 females) completed anonymous questionnaires during the period under analysis. Statistical analyses were performed by comparing the frequency of answers given by male and female students in the first and last year of the study. Results: There was a steady linear decrease in the percentages of abstainers of both genders and a regular linear increase in the number of female students abusing alcohol to blackout level in the analysed period of 2000 to 2016. The respondents’ preferences for alcohol brands became more diversified (with foreign types of strong liquors becoming more popular), and their attitudes towards alcohol availability on campus were liberalised. Conclusions: Our data complement the gaps in empirical research on alcohol consumption among university students in European countries. They point to greater homogenisation of Polish drinking culture and convergence in male and female drinking behaviours.
Infectivity of Giardia duodenalis Cysts from UV Light-Disinfected Wastewater Effluent Using a Nude BALB/c Mouse Model

Giardia duodenalis is a protozoan of public health interest that causes gastroenteritis in humans and other animals. In the city of Campinas in southeast Brazil, giardiasis is endemic, and this pathogen is detected at high concentrations in wastewater effluents, which are potential reservoirs for transmission. The Samambaia wastewater treatment plant (WWTP) in the city of Campinas employs an activated sludge system for sewage treatment and ultraviolet (UV) light for disinfection of effluents. To evaluate this disinfection process with respect to inactivating G. duodenalis cysts, two sample types were investigated: (i) effluent without UV disinfection (EFL) and (ii) effluent with UV disinfection (EFL+UV). Nude immunodeficient BALB/c mice were intragastrically inoculated with a mean dose of 14 cysts of G. duodenalis recovered from effluent from this WWTP, EFL, or EFL+UV. All animals inoculated with G. duodenalis cysts developed the infection, but animals inoculated with UV-exposed cysts released a lower average concentration of cysts in their faeces than animals inoculated with cysts that were not UV disinfected. Trophozoites were also observed in both groups of animals. These findings suggest that G. duodenalis cysts exposed to UV light were damaged but were still able to cause infection.
A novel regulatory mechanism of the mitochondrial Ca2+ uniporter revealed by the p38 mitogen‐activated protein kinase inhibitor sb202190

It is widely acknowledged that mitochondrial Ca2+ uptake modulates the cytosolic [Ca2+] ([Ca2+]c) acting as a transient Ca2+ buffer. In addition, mitochondrial [Ca2+] ([Ca2+]M) regulates the rate of respiration and may trigger opening of the permeability transition pore and start apoptosis. However, no mechanism for the physiological regulation of mitochondrial Ca2+ uptake has been described. We show here that SB202190, an inhibitor of p38 mitogen‐activated protein (MAP) kinase, strongly stimulates ruthenium red‐sensitive mitochondrial Ca2+ uptake, both in intact and in permeabilized HeLa cells. The [Ca2+]M peak induced by agonists was increased about fourfold in the presence of the inhibitor, with a concomitant reduction in the [Ca2+]c peak. The stimulation occurred fast and was rapidly reversible. In addition, experiments in permeabilized cells perfused with controlled [Ca2+] showed that SB202190 stimulated mitochondrial Ca2+ uptake by more than 10‐fold, but only in the physiological [Ca2+]c range (1–4 μM). Other structurally related p38 MAP kinase inhibitors (SB203580, PD169316, or SB220025) produced little or no effect. Our data suggest that in HeLa cells, a protein kinase sensitive to SB202190 tonically inhibits the mitochondrial Ca2+ uniporter. This novel regulatory mechanism may be of paramount importance to modulate mitochondrial Ca2+ uptake under different physiopathological conditions.
Atrial activity extraction for atrial fibrillation analysis using blind source separation

This contribution addresses the extraction of atrial activity (AA) from real electrocardiogram (ECG) recordings of atrial fibrillation (AF). We show the appropriateness of independent component analysis (ICA) to tackle this biomedical challenge when regarded as a blind source separation (BSS) problem. ICA is a statistical tool able to reconstruct the unobservable independent sources of bioelectric activity which generate, through instantaneous linear mixing, a measurable set of signals. The three key hypothesis that make ICA applicable in the present scenario are discussed and validated: 1) AA and ventricular activity (VA) are generated by sources of independent bioelectric activity; 2) AA and VA present non-Gaussian distributions; and 3) the generation of the surface ECG potentials from the cardioelectric sources can be regarded as a narrow-band linear propagation process. To empirically endorse these claims, an ICA algorithm is applied to recordings from seven patients with persistent AF. We demonstrate that the AA source can be identified using a kurtosis-based reordering of the separated signals followed by spectral analysis of the sub-Gaussian sources. In contrast to traditional methods, the proposed BSS-based approach is able to obtain a unified AA signal by exploiting the atrial information present in every ECG lead, which results in an increased robustness with respect to electrode selection and placement.
Endothelial Targeting of High-Affinity Multivalent Polymer Nanocarriers Directed to Intercellular Adhesion Molecule 1

Targeting of diagnostic and therapeutic agents to endothelial cells (ECs) provides an avenue to improve treatment of many maladies. For example, intercellular adhesion molecule 1 (ICAM-1), a constitutive endothelial cell adhesion molecule up-regulated in many diseases, is a good determinant for endothelial targeting of therapeutic enzymes and polymer nanocarriers (PNCs) conjugated with anti-ICAM (anti-ICAM/PNCs). However, intrinsic and extrinsic factors that control targeting of anti-ICAM/PNCs to ECs (e.g., anti-ICAM affinity and PNC valency and flow) have not been defined. In this study we tested in vitro and in vivo parameters of targeting to ECs of anti-ICAM/PNCs consisting of either prototype polystyrene or biodegradable poly(lactic-coglycolic) acid polymers (∼200 nm diameter spheres carrying ∼200 anti-ICAM molecules). Anti-ICAM/PNCs, but not control IgG/PNCs 1) rapidly (t1/2 ∼5 min) and specifically bound to tumor necrosis factor-activated ECs in a dose-dependent manner (Bmax ∼350 PNC/cell) at both static and physiological shear stress conditions and 2) bound to ECs and accumulated in the pulmonary vasculature after i.v. injection in mice. Anti-ICAM/PNCs displayed markedly higher EC affinity versus naked anti-ICAM (Kd ∼80 pM versus ∼8 nM) in cell culture and, probably because of this factor, higher value (185.3 ± 24.2 versus 50.5 ± 1.5% injected dose/g) and selectivity (lung/blood ratio 81.0 ± 10.9 versus 2.1 ± 0.02, in part due to faster blood clearance) of pulmonary targeting. These results 1) show that reformatting monomolecular anti-ICAM into high-affinity multivalent PNCs boosts their vascular immuno-targeting, which withstands physiological hydrodynamics and 2) support potential anti-ICAM/PNCs utility for medical applications.
The Relationship between the Establishment Age Distribution and Urban Growth

This paper explores the relationship between urban growth and establishment-level dynamics through geographic variations in the establishment age distribution. Using administrative microdata, I find that faster growing cities have higher rates of entry and exit, and younger establishments, on average. The resulting differences in the age distribution account for 38 percent of the variation in MSA employment growth, leaving the majority due to differences among establishments of the same age. In particular, entry and the growth and survival of young establishments (aged five years or less) account for the majority of the variation in MSA growth.
Self-Rated Mental Stress and Exercise Training Response in Healthy Subjects

Purpose: Individual responses to aerobic training vary from almost none to a 40% increase in aerobic fitness in healthy subjects. We hypothesized that the baseline self-rated mental stress may influence to the training response. Methods: The study population included 44 healthy sedentary subjects (22 women) and 14 controls. The laboratory controlled training period was 2 weeks, including five sessions a week at an intensity of 75% of the maximum heart rate for 40 min/session. Self-rated mental stress was assessed by inquiry prior to the training period from 1 (low psychological resources and a lot of stressors in my life) to 10 (high psychological resources and no stressors in my life), respectively. Results: Mean peak oxygen uptake (VO2peak) increased from 34 ± 7 to 37 ± 7 ml kg−1 min−1 in training group (p < 0.001) and did not change in control group (from 34 ± 7 to 34 ± 7 ml kg−1 min−1). Among the training group, the self-rated stress at the baseline condition correlated with the change in fitness after training intervention, e.g., with the change in maximal power (r = 0.45, p = 0.002, W/kg) and with the change in VO2peak (r = 0.32, p = 0.039, ml kg−1 min−1). The self-rated stress at the baseline correlated with the change in fitness in both female and male, e.g., r = 0.44, p = 0.039 and r = 0.43, p = 0.045 for ΔW/kg in female and male, respectively. Conclusion: As a novel finding the baseline self-rated mental stress is associated with the individual training response among healthy females and males after highly controlled aerobic training intervention. The changes in fitness were very low or absent in the subjects who experience their psychological resources low and a lot of stressors in their life at the beginning of aerobic training intervention.
The Contribution of Medial Temporal Lobe Atrophy and Vascular Pathology to Cognitive Impairment in Vascular Dementia

Background and Purpose— Besides cerebrovascular disease, medial temporal lobe atrophy (MTA), a neuroimaging finding suggestive of degenerative pathology, has been shown in vascular dementia (VaD). However, it is unknown to what extent MTA contributes to the pattern of cognitive impairment observed in VaD. Therefore, our purpose was to investigate the relative contribution of cerebrovascular disease and MTA to cognitive impairment in patients fulfilling diagnostic criteria for VaD. Methods— We examined 590 patients (374 men; mean age, 73 years; standard deviation, 8) with probable VaD according to the National Institute of Neurological Disorders and Stroke–Association Internationale pour la Recherche et l’Enseignement en Neurosciences criteria at inclusion into a multicenter clinical trial. Cerebrovascular disease and the degree of MTA were evaluated by using MRI. Cognitive testing included the Mini-Mental State Examination, and the vascular dementia assessment scale. Results— On the basis of the operational definitions for the neuroimaging part of the National Institute of Neurological Disorders and Stroke–Association Internationale pour la Recherche et l’Enseignement en Neurosciences criteria, 485 (82.2%) patients had small vessel VaD and 153 (25.9%) had large vessel VaD. More than half (59.8%) of the patients had considerable MTA. Multiple linear regression analyses revealed that after correction for sex, age, education, and duration of dementia, neuropsychological tests showed that patients with higher grades of MTA or large vessel VaD had significantly worse general cognitive and executive functioning, whereas associations with small vessel disease were restricted to worse executive functioning. Conclusions— Both MTA and large vessel disease contribute to global cognitive impairment in VaD. Small vessel disease contributes to executive dysfunction.
Leptin, Insulin-Like Growth Factor-1, and Insulin-Like Growth Factor-2 Are Mitogens in ApcMin/+ but not Apc+/+ Colonic Epithelial Cell Lines

The obese state is associated with elevated circulating levels of insulin, insulin-like growth factors (IGF), and leptin. Research is contradictory regarding the role of these elevated growth factors in colon cancer risk. We hypothesized that colonic epithelial cells that were Apc deficient (ApcMin/+) but not those expressing wild-type Apc (Apc+/+) would experience a hyperproliferative and antiapoptotic phenotype when exposed to these growth factors. This hypothesis was addressed using two nontumorigenic murine colonic epithelial cell lines with distinct Apc genotypes: Apc+/+ YAMC cells and ApcMin/+ IMCE cells. Cells were treated for 48 hours with various concentrations of leptin (0.001-50 ng/mL), IGF-1 (0.1-200 ng/mL), or IGF-2 (0.1-600 ng/mL). In YAMC cells, leptin caused a significant decrease in cell proliferation (P < 0.01) compared with controls due to induction of caspase activity and apoptosis. In contrast, in the IMCE cells, leptin induced a 75% increase in cell proliferation compared with controls (P < 0.0001). IGF-1 and IGF-2 also induced 50% greater proliferation in the IMCE cells (P < 0.001) compared with controls. Cotreatment of IMCE cells with leptin and either IGF-1 or IGF-2 induced greater proliferation than either growth factor alone (P < 0.0001). IMCE cell proliferation caused by leptin only treatment was associated with activation of p42/44 mitogen-activated protein kinase (MAPK), p38 MAPK, and nuclear factor-κB nuclear translocation but not with MAPK kinase or Janus-activated kinase/signal transducers and activators of transcription activation. These data provide the first evidence that leptin may interact with IGFs to promote survival and expansion of colonic epithelial cells that were Apc deficient (ApcMin/+) but not those expressing wild-type Apc (Apc+/+).
Selective Attention Modulates the Direction of Audio-Visual Temporal Recalibration

Temporal recalibration of cross-modal synchrony has been proposed as a mechanism to compensate for timing differences between sensory modalities. However, far from the rich complexity of everyday life sensory environments, most studies to date have examined recalibration on isolated cross-modal pairings. Here, we hypothesize that selective attention might provide an effective filter to help resolve which stimuli are selected when multiple events compete for recalibration. We addressed this question by testing audio-visual recalibration following an adaptation phase where two opposing audio-visual asynchronies were present. The direction of voluntary visual attention, and therefore to one of the two possible asynchronies (flash leading or flash lagging), was manipulated using colour as a selection criterion. We found a shift in the point of subjective audio-visual simultaneity as a function of whether the observer had focused attention to audio-then-flash or to flash-then-audio groupings during the adaptation phase. A baseline adaptation condition revealed that this effect of endogenous attention was only effective toward the lagging flash. This hints at the role of exogenous capture and/or additional endogenous effects producing an asymmetry toward the leading flash. We conclude that selective attention helps promote selected audio-visual pairings to be combined and subsequently adjusted in time but, stimulus organization exerts a strong impact on recalibration. We tentatively hypothesize that the resolution of recalibration in complex scenarios involves the orchestration of top-down selection mechanisms and stimulus-driven processes.
Spatial and temporal distribution of solar radiation in Louisiana

The purpose of this study is to examine temporal and spatial trends in surface global horizontal solar radiation in Louisiana using a 30-year dataset (1961-1990) of the four stations in Louisiana from the National Solar Radiation Database (NSRD) and a 6-year dataset (2001-2006) of the 25 stations in the Louisiana Agriclimatic Information System (LAIS). Three of the four NSRD stations exhibit a downward linear trend in surface solar radiation over the 30-year period of record, similar to the global trends uncovered in previous studies. Only one station exhibits a slightly upward trend. Surface solar radiation exhibits a positive correlation with maximum temperature but a negative correlation with minimum temperature. A higher solar radiation transmissivity in summer is found in Shreveport than at the three sites in southern Louisiana, despite a more direct sun angle in the south. Southeastern Louisiana (represented by New Orleans) is found to have lower transmissivity values than southwestern Louisiana (represented by Lake Charles), probably because of the stronger influence of large water bodies in the southeast. A summertime slump in transmissivity is found at all NSRD stations for a ‘normal’ averaged year. Data from the NSRD were used to validate data values from each LAIS station. While most LAIS stations have inadequate data, at least in some sections of the six-year time series, some stations appear adequate for future research applications.
Spherical averages and applications to spherical splines and interpolation

This article introduces a method for computing weighted averages on spheres based on least squares minimization that respects spherical distance. We prove existence and uniqueness properties of the weighted averages, and give fast iterative algorithms with linear and quadratic convergence rates. Our methods are appropriate to problems involving averages of spherical data in meteorological, geophysical, and astronomical applications. One simple application is a method for smooth averaging of quaternions, which generalizes Shoemake's spherical linear interpolation.The weighted averages methods allow a novel method of defining Bézier and spline curves on spheres, which provides direct generalization of Bézier and B-spline curves to spherical spline curves. We present a fast algorithm for spline interpolation on spheres. Our spherical splines allow the use of arbitrary knot positions; potential applications of spherical splines include smooth quaternion curves for applications in graphics, animation, robotics, and motion planning.