Miracle-dz/UniFAR-FTUs huggingface dataset:
Sorting and Social Preferences

Laboratory experiments on social preferences typically do not allow for sorting, while many field settings do. We demonstrate a strong effect of sorting when introduced in the laboratory. Across four experiments, most individuals who share with others do so reluctantly, preferring to avoid the opportunity to share. The attractiveness of the sorting option strongly affects the composition of self-selected participants. Subsidized entry into the sharing environment attracts those who share the least. Costly entry attracts few participants, but those share large amounts. Finally, we find that a similar proportion of sharers opt out even after inducing positive reciprocity. * We thank Jordi Brandts, Colin Camerer, Stefano DellaVigna, Hank Farber, Ernst Fehr, Glenn Harrison, Larry Katz, Botond Koszegi, Klaus Schmidt, Georg Weizsacker, as well as participants at several seminars and conferences for helpful comments. We also thank Jason Dana, Scott Rick, Aniol Llorente and David Rodriguez for help in conducting the experiments and the Pittsburgh Experimental Economics Laboratory (PEEL), the Laboratori d'Economia Experimental (LEEX), and the Berkeley Experimental Social Science Laboratory (XLab) for access to their resources.
A fast and accurate parallel algorithm for non-linear image registration using Normalized Gradient fields

We present a novel parallelized formulation for fast non-linear image registration. By carefully analyzing the mathematical structure of the intensity independent Normalized Gradient Fields distance measure, we obtain a scalable, parallel algorithm that combines fast registration and high accuracy to an attractive package. Based on an initial formulation as an optimization problem, we derive a per pixel parallel formulation that drastically reduces computational overhead. The method was evaluated on ten publicly available 4DCT lung datasets, achieving an average registration error of only 0.94 mm at a runtime of about 20 s. By omitting the finest level, we obtain a speedup to 6.56 s with a moderate increase of registration error to 1.00 mm. In addition our algorithm shows excellent scalability on a multi-core system.
Guided Depth Upsampling via a Cosparse Analysis Model

This paper proposes a new approach to upsample depth maps when aligned high-resolution color images are given. Such a task is referred to as guided depth upsampling in our work. We formulate this problem based on the recently developed sparse representation analysis models. More specifically, we exploit the cosparsity of analytic analysis operators performed on a depth map, together with data fidelity and color guided smoothness constraints for upsampling. The formulated problem is solved by the greedy analysis pursuit algorithm. Since our approach relies on the analytic operators such as the Wavelet transforms and the finite difference operators, it does not require any training data but a single depth-color image pair. A variety of experiments have been conducted on both synthetic and real data. Experimental results demonstrate that our approach outperforms the specialized state-of-the-art algorithms.
DOES SELECTION ON FLORAL ODOR PROMOTE DIFFERENTIATION AMONG POPULATIONS AND SPECIES OF THE SEXUALLY DECEPTIVE ORCHID GENUS OPHRYS?

Abstract Sexually deceptive orchids from the genus Ophrys attract their pollinators primarily through the chemical mimicry of female hymenopteran sex pheromones, thereby deceiving males into attempted matings with the orchid labellum. Floral odor traits are crucial for the reproductive success of these pollinator-limited orchids, as well as for maintaining reproductive isolation through the attraction of specific pollinators. We tested for the signature of pollinator-mediated selection on floral odor by comparing intra and interspecific differentiation in odor compounds with that found at microsatellite markers among natural populations. Three regions from southern Italy were sampled. We found strong floral odor differentiation among allopatric populations within species, among allopatric species and among sympatric species. Population differences in odor were also reflected in significant variation in the attractivity of floral extracts to the pollinator, Colletes cunicularius. Odor compounds that are electrophysiologically active in C. cunicularius males, especially alkenes, were more strongly differentiated among conspecific populations than non-active compounds in the floral odor. In marked contrast to these odor patterns, there was limited population or species level differentiation in microsatellites (FST range 0.005 to 0.127, mean FST 0.075). We propose that the strong odor differentiation and lack of genetic differentiation among sympatric taxa indicates selection imposed by the distinct odor preferences of different pollinating species. Within species, low FST values are suggestive of large effective population sizes and indicate that divergent selection rather than genetic drift accounts for the strong population differentiation in odor. The higher differentiation in active versus non-active odor compounds suggests that divergent selection among orchid populations may be driven by local pollinator preferences for those particular compounds critical for pollinator attraction.
A Comparison of Bilateral Breast Cancers in BRCA Carriers

Background: Women with breast cancer and a BRCA mutation have a high risk of developing a contralateral breast cancer. It is generally believed that the two cancers represent independent events. However, the extent of concordance between the first and second tumors with respect to hormone receptor expression and other pathologic features is unknown. Purpose: To determine the degree of concordance of estrogen receptor (ER) status, tumor grade, and histology in tumors from women with bilateral breast cancer and a BRCA mutation. Subjects and Methods: Women with a history of bilateral invasive breast cancers were selected from an international registry of women with BRCA1 or BRCA2 mutations. Medical records were reviewed to document the characteristics of each cancer and the treatments received. Results: Data were available for 286 women with bilateral breast cancer and a BRCA mutation (211 BRCA1; 75 BRCA2). The mean interval between first and second tumor was 5.1 years. The two tumors were concordant more often than expected for ER status (P < 0.0001) and for grade (P < 0.0001), but not for histology (P = 0.55). The ER status of the first tumor was highly predictive of the ER status of the second tumor (odds ratio, 8.7; 95% confidence interval, 3.5-21.5; P < 0.0001). Neither age, menopausal status, oophorectomy nor tamoxifen use was predictive of the ER status of the second tumor. Conclusions: There is strong concordance in ER status and tumor grade between independent primary breast tumors in women with a BRCA mutation. The excess concordance may be due to common risk factors, genetic variation, or the existence of a preneoplastic lesion that is common to both tumors.
Human Monoclonal Rheumatoid Synovial B Lymphocyte Hybridoma with a New Disease-Related Specificity for Cartilage Oligomeric Matrix Protein1

Joint-specific self-Ags are considered to play an important role in the induction of synovial T and B cell expansion in human rheumatoid arthritis (RA). However, the nature of these autoantigens is still enigmatic. In this study a somatically mutated IgG2λ B cell hybridoma was established from the synovial membrane of an RA patient and analyzed for its Ag specificity. A heptameric peptide of cartilage oligomeric matrix protein (COMP) could be characterized as the target structure recognized by the human synovial B cell hybridoma. The clonotypic VH sequences of the COMP-specific hybridoma could also be detected in synovectomy material derived from five different RA patients but in none of the investigated osteoarthritis cases (n = 5), indicating a preferential usage of VH genes closely related to those coding for a COMP-specific Ag receptor in RA synovial B cells. Moreover, the COMP heptamer was preferentially recognized by circulating IgG in RA (n = 22) compared with osteoarthritis patients (n = 24) or age-matched healthy controls (n = 20; both p < 0.0001). Hence, the COMP-specific serum IgG is likely to reflect local immune responses toward a cartilage- and tendon-restricted Ag that might be crucial to the induction of tissue damage in RA.
Association between Dietary Cadmium Exposure and Breast Cancer Risk: An Updated Meta-Analysis of Observational Studies

BACKGROUND Diet is the primary way cadmium (Cd) enters the body in those without occupational exposure and who do not inhabit Cd-polluted regions. Findings on the relationship between dietary Cd exposure and breast cancer (BC) risk have been inconsistent; a meta-analysis has supported this association but 2 recent cohort studies showed inconsistent results. Hence, we performed an updated meta-analysis to re-evaluate the association between dietary Cd exposure and BC risk. MATERIAL AND METHODS We searched PubMed, Medline, and EMBASE to identify relevant studies published through September 2014. Combined relative risks (RRs) and the corresponding 95% confidence intervals (CIs) were used to assess the association between dietary Cd exposure and BC risk. RESULTS We identified 6 studies involving 321 315 participants and 11 978 cases. Our study suggested there was no statistically significant positive association between dietary Cd exposure and BC risk, the combined RR and corresponding 95% CI was 1.01 [0.88, 1.14]. The result was not modified by menopause status, geographic area, or study design. CONCLUSIONS Our study did not find a statistically significant positive association between dietary Cd exposure and BC risk. It is necessary to investigate this relationship among the high-risk groups and more cohort studies based on diverse populations are needed.
XRCC1 Arg399Gln polymorphism and risk for cervical cancer development in Argentine women.

BACKGROUND XRCC1 (X-ray repair cross-complementing group 1) plays a central role in the DNA base excision repair mechanism. Single nucleotide polymorphisms (SNPs) in the XRCC1 gene are thought to modulate DNA repair capacity and have been linked to cancer risk in several studies. MATERIALS AND METHODS We conducted a case-control study comprising 217 cervical samples, including 103 cervical carcinomas and 114 normal tissue samples. Cervical samples were genotyped for two XRCC1 SNPs (Arg194Trp and Arg399Gln) by PCR-RFLPs. RESULTS Subjects carrying heterozygous Arg399Gln or the combined Gln399Gln + Arg399Gln variant genotypes had a significantly reduced risk for cervical cancer development. In addition, the 194Arg-399Gln haplotype was also found to be associated with a decreased risk for cervical carcinoma. CONCLUSION Our findings suggest that XRCC1 genotypes and haplotypes contribute in reducing the risk for cervical cancer development. Furthermore, genetic susceptibility conferred by Arg399Gln polymorphism operates independently of human papillomavirus infection of cervical tissue.
Effects of Knowledge on Attitude Formation and Change Toward Genetically Modified Foods

In three waves, this study investigates the impact of risk and benefit knowledge on attitude formation toward genetically modified (GM) foods as well as the moderating effect of knowledge level on attitude change caused by receiving information. The data in Wave 1 (N = 561) demonstrate that both benefit and risk knowledge either directly contribute to attitude formation or indirectly affect attitudes through the mediating roles of benefit and risk perceptions. Overall, benefit and risk knowledge affect consumer attitudes positively and negatively, respectively. In Wave 2, 486 participants from Wave 1 were provided with information about GM foods, and their attitudes were assessed. Three weeks later, 433 of these participants again reported their attitudes. The results indicate that compared with the benefit and mixed information, risk information has a greater and longer lasting impact on attitude change, which results in lower acceptance of GM foods. Furthermore, risk information more strongly influences participants with a higher knowledge level. The moderating effect of knowledge on attitude change may result from these participants’ better understanding of and greater trust in the information. These findings highlight the important role of knowledge in attitude formation and attitude change toward GM foods as well as the necessity of considering the determinants of attitude formation in attitude change studies.
Developing and establishing bee species as crop pollinators: the example of Osmia spp. (Hymenoptera: Megachilidae) and fruit trees

Abstract The development of a bee species as a new crop pollinator starts with the identification of a pollination-limited crop production deficit and the selection of one or more candidate pollinator species. The process continues with a series of studies on the developmental biology, pollinating efficacy, nesting behaviour, preference for different nesting substrates, and population dynamics of the candidate pollinator. Parallel studies investigate the biology of parasites, predators and pathogens. The information gained in these studies is combined with information on the reproductive biology of the crop to design a management system. Complete management systems should provide guidelines on rearing and releasing methods, bee densities required for adequate pollination, nesting materials, and control against parasites, predators and pathogens. Management systems should also provide methods to ensure a reliable pollinator supply. Pilot tests on a commercial scale are then conducted to test and eventually refine the management system. The process culminates with the delivery of a viable system to manage and sustain the new pollinator on a commercial scale. The process is illustrated by the development of three mason bees, Osmia cornifrons (Radoszkowski), O. lignaria Say and O. cornuta (Latreille) as orchard pollinators in Japan, the USA and Europe, respectively.
The neural bases of the multiplication problem-size effect across countries

Multiplication problems involving large numbers (e.g., 9 × 8) are more difficult to solve than problems involving small numbers (e.g., 2 × 3). Behavioral research indicates that this problem-size effect might be due to different factors across countries and educational systems. However, there is no neuroimaging evidence supporting this hypothesis. Here, we compared the neural correlates of the multiplication problem-size effect in adults educated in China and the United States. We found a greater neural problem-size effect in Chinese than American participants in bilateral superior temporal regions associated with phonological processing. However, we found a greater neural problem-size effect in American than Chinese participants in right intra-parietal sulcus (IPS) associated with calculation procedures. Therefore, while the multiplication problem-size effect might be a verbal retrieval effect in Chinese as compared to American participants, it may instead stem from the use of calculation procedures in American as compared to Chinese participants. Our results indicate that differences in educational practices might affect the neural bases of symbolic arithmetic.
Assessment of subchondral bone marrow lipids in healthy controls and mild osteoarthritis patients at 3T

The compartment‐specific lipid changes in femoral–tibial bone of healthy controls and mild osteoarthritis (OA) patients were quantified at 3.0 T. Healthy volunteers [Kellgren–Lawrence (KL) grade = 0; n = 15, 4 females, 11 males, mean age 39 ± 16 years, age range = 24–78 years] and mild OA patients (KL = 1, 2; n = 26, 12 females, 14 males, mean age 61 ± 14 years, age range = 27–80 years) were scanned on a 3 T scanner. Clinical proton density (PD)‐weighted fast spin echo (FSE) images in the sagittal (without fat‐saturation), axial and coronal (fat‐saturation) planes were acquired for cartilage Whole‐Organ MR Imaging Score (WORMS) grading. A voxel of 10 × 10 × 10 mm3 was positioned in the medial and lateral compartments of the tibia [medial tibial (MT) and lateral tibial (LT)] and femur [medial femoral (MF) and lateral femoral (LF)] for MRS measurements using the single voxel‐stimulated echo acquisition mode (STEAM) pulse sequence. All MRS data were processed with Java‐based Magnetic Resonance User Interface (JMRUI). Wilcoxon's rank sum test and mixed model two‐way analysis of variance ( anova) were performed to determine significant differences between different compartments as well as examine the effect of OA grade and compartment, and their interactions. Generally, the MF compartment index of unsaturation was increased in healthy subjects compared with OA subjects (whether graded by KL or WORMS score). Differences between MF at KL0 and all other compartments at KL1 except LF approached statistical significance (p < 0.05). Differences in saturated lipids signals could be observed predominantly in the 2.03 p.p.m. frequency shift. Healthy controls in the MF compartment had the lowest saturated lipid signals, and mild OA patients with KL2 and WORMS5‐6 in the MF compartment had the highest saturated lipid signals compared with other compartments at 2.03 p.p.m. (p < 0.05). Copyright © 2011 John Wiley & Sons, Ltd.
Identification of a Neuropeptide S Responsive Circuitry Shaping Amygdala Activity via the Endopiriform Nucleus

Neuropeptide S (NPS) and its receptor are thought to define a set of specific brain circuits involved in fear and anxiety. Here we provide evidence for a novel, NPS-responsive circuit that shapes neural activity in the mouse basolateral amygdala (BLA) via the endopiriform nucleus (EPN). Using slice preparations, we demonstrate that NPS directly activates an inward current in 20% of EPN neurons and evokes an increase of glutamatergic excitation in this nucleus. Excitation of the EPN is responsible for a modulation of BLA activity through NPS, characterized by a general increase of GABAergic inhibition and enhancement of spike activity in a subset of BLA projection neurons. Finally, local injection of NPS to the EPN interferes with the expression of contextual, but not auditory cued fear memory. Together, these data suggest the existence of a specific NPS-responsive circuitry between EPN and BLA, likely involved in contextual aspects of fear memory.
Predictive Control for Constrained Image-Based Visual Servoing

This paper deals with the image-based visual servoing (IBVS), subject to constraints. Robot workspace limitations, visibility constraints, and actuators limitations are addressed. These constraints are formulated into state, output, and input constraints, respectively. Based on the predictive-control strategy, the IBVS task is written into a nonlinear optimization problem in the image plane, where the constraints can be easily and explicitly taken into account. Second, the contribution of the image prediction and influence of the prediction horizon are pointed out. The image prediction is obtained due to a model. The latter can be a local model based on the interaction matrix or a nonlinear global model based on 3-D data. Its choice is discussed with respect to the constraints to be handled. Finally, simulations that were obtained with a 6-degree-of-freedom (DOF) free-flying camera highlight the potential advantages of the proposed approach with respect to the image prediction and the constraint handling.
A novel microglial subset plays a key role in myelinogenesis in developing brain

Microglia are resident macrophages of the central nervous system that contribute to homeostasis and neuroinflammation. Although known to play an important role in brain development, their exact function has not been fully described. Here, we show that in contrast to healthy adult and inflammation‐activated cells, neonatal microglia show a unique myelinogenic and neurogenic phenotype. A CD11c+ microglial subset that predominates in primary myelinating areas of the developing brain expresses genes for neuronal and glial survival, migration, and differentiation. These cells are the major source of insulin‐like growth factor 1, and its selective depletion from CD11c+ microglia leads to impairment of primary myelination. CD11c‐targeted toxin regimens induced a selective transcriptional response in neonates, distinct from adult microglia. CD11c+ microglia are also found in clusters of repopulating microglia after experimental ablation and in neuroinflammation in adult mice, but despite some similarities, they do not recapitulate neonatal microglial characteristics. We therefore identify a unique phenotype of neonatal microglia that deliver signals necessary for myelination and neurogenesis.
The Immunomodulatory Action of Sialostatin L on Dendritic Cells Reveals Its Potential to Interfere with Autoimmunity1

Sialostatin L (SialoL) is a secreted cysteine protease inhibitor identified in the salivary glands of the Lyme disease vector Ixodes scapularis. In this study, we reveal the mechanisms of SialoL immunomodulatory actions on the vertebrate host. LPS-induced maturation of dendritic cells from C57BL/6 mice was significantly reduced in the presence of SialoL. Although OVA degradation was not affected by the presence of SialoL in dendritic cell cultures, cathepsin S activity was partially inhibited, leading to an accumulation of a 10-kDa invariant chain intermediate in these cells. As a consequence, in vitro Ag-specific CD4+ T cell proliferation was inhibited in a time-dependent manner by SialoL, and further studies engaging cathepsin S−/− or cathepsin L−/− dendritic cells confirmed that the immunomodulatory actions of SialoL are mediated by inhibition of cathepsin S. Moreover, mice treated with SialoL displayed decreased early T cell expansion and recall response upon antigenic stimulation. Finally, SialoL administration during the immunization phase of experimental autoimmune encephalomyelitis in mice significantly prevented disease symptoms, which was associated with impaired IFN-γ and IL-17 production and specific T cell proliferation. These results illuminate the dual mechanism by which a human disease vector protein modulates vertebrate host immunity and reveals its potential in prevention of an autoimmune disease.
Evidence in hand: recent discoveries and the early evolution of human manual manipulation

For several decades, it was largely assumed that stone tool use and production were abilities limited to the genus Homo. However, growing palaeontological and archaeological evidence, comparative extant primate studies, as well as results from methodological advancements in biomechanics and morphological analyses, have been gradually accumulating and now provide strong support for more advanced manual manipulative abilities and tool-related behaviours in pre-Homo hominins than has been traditionally recognized. Here, I review the fossil evidence related to early hominin dexterity, including the recent discoveries of relatively complete early hominin hand skeletons, and new methodologies that are providing a more holistic interpretation of hand function, and insight into how our early ancestors may have balanced the functional requirements of both arboreal locomotion and tool-related behaviours.
Evolution of galaxy clustering

We study the evolution of the correlation function of dark matter haloes in the CDM class of models. We show that the halo correlation function does not evolve in proportion with the correlation function of the underlying mass distribution. The earliest haloes to collapse, which correspond to rare peaks in the density field, cluster very strongly. The amplitude of the halo correlation function decreases from its initial, large, value. This decrease continues until the average peaks have collapsed, after which the amplitude grows slowly. This behaviour is shown to be generic and the epoch of minimum amplitude depends only on the rms fluctuations in mass at the relevant scale and, to a much smaller extent, on the slope of the power spectrum at that scale. We discuss the relevance of this result for interpretation of observations of galaxy and quasar clustering.