Miracle-dz/UniFAR-FTUs huggingface dataset:
Radical prostatectomy for locally advanced and metastatic prostate cancer

ABSTRACT The management of advanced prostate cancer remains challenging. Traditionally, radical prostatectomy was discouraged in patients with locally advanced or node positive disease owing to the increased complication rate and treatment related morbidity. However, technical advances and refinements in surgical techniques have enabled the outcomes for patients with high risk prostate cancer to be improved. More recently, the concept of cytoreductive prostatectomy has been described where surgery (often Combined with an extended lymph node dissection) is performed in the setting of metastatic disease. Indirect evidence suggests an advantage using the cytoreductive approach. Hypothetical explanations for this observed benefit include decreased tumour burden, immune modulation, improved response to secondary treatment and avoidance of secondary complications attributable to local tumour growth. Nevertheless, prospective trials are required to investigate this further.
EFFECTS INDUCED BY INITIAL CHITOSAN SOLUTION CONCENTRATION AND CHITIN AND GLYCEROL INCORPORATION ON THE CHARACTERISTICS OF DENSE CHITOSAN MEMBRANES WITH POTENTIAL USE AS BURN DRESSINGS

The aim of this work was to study the effects induced by chitosan solution concentration (1.0 and 2.5%) and by chitin and glycerol incorporation on dense chitosan membranes with potential use as burn dressings. The membrane properties analyzed were total raw material cost, morphology, cristallinity, swelling ratio, tensile strength, percentage of strain at break, in vitro enzymatic degradation with lysozyme, in vitro cell adhesion and stability in aqueous solutions. The use of the most concentrated chitosan solution reduced the biomaterials cost, cristallinity and swelling ratio in distilled water. The remaining evaluated properties were not affected by chitosan solution concentration. The incorporation of chitin and glycerol produced biomaterials with irregular surface, reduced the membranes cost, cristallinity, swelling ratio, mechanical properties and improved their degradation by lysozyme. When a neutralization stage was included in the chitosan membranes preparation, all formulations showed stability in aqueous solutions. The overall results indicate that most of the prepared membranes meet the performance requirements of temporary non-biodegradable burn dressings.
The Cracked Mirror: Features of Narcissistic Personality Disorder in Children

The notion of character disorder in children remains highly controversial given unanswered questions regarding personality formation. According to the Diagnostic and Statistical Manual of Mental Disorders, fourth edition,1 personality is defi ned as “enduring patterns of perceiving, relating to and thinking about the environment and oneself . when they are maladaptive and infl exible, they constitute Personality Disorders. ”1 Currently, such disorders are “generally recognized by adolescence or earlier. ” DSM-IV continues, however, by emphasizing corresponding diagnoses given to children and adolescents, such as Conduct Disorder, as an earlier equivalent to Antisocial Personality Disorder. Narcissistic Personality Disorder (NPD) has no such equivalent despite the acknowledgment that it develops earlier than 18 years. The ambivalence and ambiguity regarding personality disorder in children are further highlighted by the suggestion that one can apply the diagnosis of personality Karen Kernberg Bardenstein, PhD
Tubulin Dimer Reversible Dissociation

Tubulins are evolutionarily conserved proteins that reversibly polymerize and direct intracellular traffic. Of the tubulin family only αβ-tubulin forms stable dimers. We investigated the monomer-dimer equilibrium of rat brain αβ-tubulin using analytical ultracentrifugation and fluorescence anisotropy, observing tubulin in virtually fully monomeric and dimeric states. Monomeric tubulin was stable for a few hours and exchanged into preformed dimers, demonstrating reversibility of dimer dissociation. Global analysis combining sedimentation velocity and fluorescence anisotropy yielded Kd = 84 (54–123) nm. Dimer dissociation kinetics were measured by analyzing the shape of the sedimentation boundary and by the relaxation of fluorescence anisotropy following rapid dilution of labeled tubulin, yielding koff in the range 10−3–10−2 s−1. Thus, tubulin dimers reversibly dissociate with moderately fast kinetics. Monomer-monomer association is much less sensitive than dimer-dimer association to solution changes (GTP/GDP, urea, and trimethylamine oxide).
Involvement of Macrophage Inflammatory Protein-1 Family Members in the Development of Diabetic Neuropathy and Their Contribution to Effectiveness of Morphine

Current investigations underline the important roles of C–C motif ligands in the development of neuropathic pain; however, their participation in diabetic neuropathy is still undefined. Therefore, the goal of our study was to evaluate the participation of macrophage inflammatory protein-1 (MIP-1) family members (CCL3, CCL4, CCL9) in a streptozotocin (STZ)-induced mouse model of diabetic neuropathic pain. Single intrathecal administration of each MIP-1 member (10, 100, or 500 ng/5 μl) in naïve mice evoked hypersensitivity to mechanical (von Frey test) and thermal (cold plate test) stimuli. Concomitantly, protein analysis has shown that, 7 days following STZ injection, the levels of CCL3 and CCL9 (but not CCL4) are increased in the lumbar spinal cord. Performed additionally, immunofluorescence staining undoubtedly revealed that CCL3, CCL9, and their receptors (CCR1 and CCR5) are expressed predominantly by neurons. In vitro studies provided evidence that the observed expression of CCL3 and CCL9 may be partially of glial origin; however, this observation was only partially possible to confirm by immunohistochemical study. Single intrathecal administration of CCL3 or CCL9 neutralizing antibody (2 and 4 μg/5 μl) delayed neuropathic pain symptoms as measured at day 7 following STZ administration. Single intrathecal injection of a CCR1 antagonist (J113863; 15 and 20 μg/5 μl) also attenuated pain-related behavior as evaluated at day 7 after STZ. Both neutralizing antibodies, as well as the CCR1 antagonist, enhanced the effectiveness of morphine in STZ-induced diabetic neuropathy. These findings highlight the important roles of CCL3 and CCL9 in the pathology of diabetic neuropathic pain and suggest that they play pivotal roles in opioid analgesia.
DICER1 and Associated Conditions: Identification of At-risk Individuals and Recommended Surveillance Strategies

Pathogenic germline DICER1 variants cause a hereditary cancer predisposition syndrome with a variety of manifestations. In addition to conferring increased cancer risks for pleuropulmonary blastoma (PPB) and ovarian sex cord–stromal tumors, particularly Sertoli–Leydig cell tumor, individuals with pathogenic germline DICER1 variants may also develop lung cysts, cystic nephroma, renal sarcoma and Wilms tumor, nodular hyperplasia of the thyroid, nasal chondromesenchymal hamartoma, ciliary body medulloepithelioma, genitourinary embryonal rhabdomyosarcoma, and brain tumors including pineoblastoma and pituitary blastoma. In May 2016, the International PPB Registry convened the inaugural International DICER1 Symposium to develop consensus testing and surveillance and treatment recommendations. Attendees from North America, Europe, and Russia provided expert representation from the disciplines of pediatric oncology, endocrinology, genetics, genetic counseling, radiology, pediatric surgery, pathology, and clinical research. Recommendations are provided for genetic testing; prenatal management; and surveillance for DICER1-associated pulmonary, renal, gynecologic, thyroid, ophthalmologic, otolaryngologic, and central nervous system tumors and gastrointestinal polyps. Risk for most DICER1-associated neoplasms is highest in early childhood and decreases in adulthood. Individual and caregiver education and judicious imaging-based surveillance are the primary recommended approaches. These testing and surveillance recommendations reflect a consensus of expert opinion and current literature. As DICER1 research expands, guidelines for screening and treatment will continue to be updated. Clin Cancer Res; 24(10); 2251–61. ©2018 AACR.
Age-related differences in skeletal muscle lipid profiles of Weddell seals: clues to developmental changes

SUMMARY Our objective was to elucidate age-related changes in lipids associated with skeletal muscle of Weddell seals and to suggest possible physiological implications. Muscle biopsies were collected from pups, juveniles and adults in McMurdo Sound, Antarctica and analyzed for intramuscular lipid (IML) and triacylglyceride (IMTG) amounts, fatty acid groups, as well as individual fatty acid profiles. The results from this study suggest a switch from primarily saturated fatty acids (SFAs) and monounsaturated fatty acids (MUFAs) in the skeletal muscle of young pups to increases in polyunsaturated fatty acids (PUFAs) as the percentage of blubber increases, resulting in possible thermoregulatory benefits. As Weddell pups continue to develop into juveniles, fatty acids associated with the skeletal muscle changes such that MUFA levels are relatively higher, which may be in response to energy depletion associated with their restricted diving ability and rapid growth. As juveniles transform into adults, a reduction in n-3 PUFA levels in the muscle as the percentage of blubber increases may be indicative of a trigger to prepare for deep diving or could be a mechanism for oxygen conservation during long-duration dives. We speculate that the observed change in lipids associated with the skeletal muscle of Weddell seals is related to ontogenetic differences in thermoregulation and locomotion.
Suppression of protein tyrosine phosphatase N23 predisposes to breast tumorigenesis via activation of FYN kinase

Zhang et al. identified PTPN23 as a suppressor of cell motility and invasion in mammary epithelial and breast cancer cells. They validated the underlying mechanism of PTPN23 function in breast tumorigenesis as that of a key phosphatase that normally suppresses the activity of FYN in two different models.
Metatranscriptomics and Amplicon Sequencing Reveal Mutualisms in Seagrass Microbiomes

Terrestrial plants benefit from many well-understood mutualistic relationships with root- and leaf-associated microbiomes, but relatively little is known about these relationships for seagrass and other aquatic plants. We used 16S rRNA gene amplicon sequencing and metatranscriptomics to assess potential mutualisms between microorganisms and the seagrasses Zostera marina and Zostera japonica collected from mixed beds in Netarts Bay, OR, United States. The phylogenetic composition of leaf-, root-, and water column-associated bacterial communities were strikingly different, but these communities were not significantly different between plant species. Many taxa present on leaves were related to organisms capable of consuming the common plant metabolic waste product methanol, and of producing agarases, which can limit the growth of epiphytic algae. Taxa present on roots were related to organisms capable of oxidizing toxic sulfur compounds and of fixing nitrogen. Metatranscriptomic sequencing identified expression of genes involved in all of these microbial metabolic processes at levels greater than typical water column bacterioplankton, and also identified expression of genes involved in denitrification and in bacterial synthesis of the plant growth hormone indole-3-acetate. These results provide the first evidence using metatranscriptomics that seagrass microbiomes carry out a broad range of functions that may benefit their hosts, and imply that microbe–plant mutualisms support the health and growth of aquatic plants.
A Prospective Study of Chronic Inflammation in Benign Prostate Tissue and Risk of Prostate Cancer: Linked PCPT and SELECT Cohorts

Background: We leveraged two trials to test the hypothesis of an inflammation–prostate cancer link prospectively in men without indication for biopsy. Methods: Prostate Cancer Prevention Trial (PCPT) participants who had an end-of-study biopsy performed per protocol that was negative for cancer and who subsequently enrolled in the Selenium and Vitamin E Cancer Prevention Trial (SELECT) were eligible. We selected all 100 cases and sampled 200 frequency-matched controls and used PCPT end-of-study biopsies as “baseline. ” Five men with PSA > 4 ng/mL at end-of-study biopsy were excluded. Tissue was located for 92 cases and 193 controls. We visually assessed inflammation in benign tissue. We estimated ORs and 95% confidence intervals (CI) using logistic regression adjusting for age and race. Results: Mean time between biopsy and diagnosis was 5.9 years. In men previously in the PCPT placebo arm, 78.1% of cases (N = 41) and 68.2% of controls (N = 85) had at least one baseline biopsy core (∼5 evaluated per man) with inflammation. The odds of prostate cancer (N = 41 cases) appeared to increase with increasing mean percentage of tissue area with inflammation, a trend that was statistically significant for Gleason sum <4+3 disease (N = 31 cases; vs. 0%, >0–<1.8% OR = 1.70, 1.8–<5.0% OR = 2.39, ≥5% OR = 3.31, Ptrend = 0.047). In men previously in the finasteride arm, prevalence of inflammation did not differ between cases (76.5%; N = 51) and controls (75.0%; N = 108). Conclusions: Benign tissue inflammation was positively associated with prostate cancer. Impact: This first prospective study of men without biopsy indication supports the hypothesis that inflammation influences prostate cancer development. Cancer Epidemiol Biomarkers Prev; 26(10); 1549–57. ©2017 AACR.
A methodology for estimating the permeability of a soot deposit in a wall-flow diesel particulate filter

An estimation of the realistic permeability of a soot deposit layer accumulated in a wall-flow diesel particulate filter was performed in this study. A unique contribution of this work is that the current methodology is highly applicable to the real-world design and development processes of diesel particulate filters. To conduct baseline simulation, a one-dimensional numerical model describing the behaviours of the exhaust gas and soot within a diesel particulate filter was constructed, employing the well-known single-channel approach. On the basis of this in-house model, the microstructural properties of a soot deposit layer were calibrated by finding the best fit to the measurement data adopted from the open literature. For the optimal applicability of the proposed methodology, the permeability of the deposit is modelled as a variable which depends on the temperature and the average wall velocity, while the porosity is constant. The current model and methodology were validated by comparison with the measurement data for pressure drops through diesel particulate filters. In particular, to boost the practical implementation of the current methodology, a map of the permeability of the soot deposit was created as a function of the operating conditions. In the last part of this study, the pressure drop characteristics through a diesel particulate filter under various operating conditions were examined using an analysis of the breakdown of the individual pressure drop mechanisms.
Boosting Self-Supervised Learning via Knowledge Transfer

In self-supervised learning, one trains a model to solve a so-called pretext task on a dataset without the need for human annotation. The main objective, however, is to transfer this model to a target domain and task. Currently, the most effective transfer strategy is fine-tuning, which restricts one to use the same model or parts thereof for both pretext and target tasks. In this paper, we present a novel framework for self-supervised learning that overcomes limitations in designing and comparing different tasks, models, and data domains. In particular, our framework decouples the structure of the self-supervised model from the final task-specific fine-tuned model. This allows us to: 1) quantitatively assess previously incompatible models including handcrafted features; 2) show that deeper neural network models can learn better representations from the same pretext task; 3) transfer knowledge learned with a deep model to a shallower one and thus boost its learning. We use this framework to design a novel self-supervised task, which achieves state-of-the-art performance on the common benchmarks in PASCAL VOC 2007, ILSVRC12 and Places by a significant margin. Our learned features shrink the mAP gap between models trained via self-supervised learning and supervised learning from 5.9% to 2.6% in object detection on PASCAL VOC 2007.
Oral health benefits of chewing gum

In the last decades sugar-free chewing gum has developed in an oral healthcare product, next to the conventional products such as the toothbrush and mouthrinses. In this thesis we investigate the oral health benefits of chewing gum and the effects of additives to chewing gum, such as antimicrobials. Herein, the focus is on oral bacteria and the oral biofilm, or dental plaque, which is a sticky layer of bacteria that forms on the teeth. Oral bacteria can be divided into good and bad bacteria, in which the formation of the oral biofilm is the root cause of many oral diseases as caries, gingivitis or periodontitis. In this thesis it is shown that the major oral health benefits of sugar-free chewing gum are centered around the stimulation of saliva during mastication and that the effects of additives to chewing gum require long term use and are often difficult to prove. Furthermore, we looked into new possibilities to improve the oral health benefits of chewing gum. In which we emphasized removing specifically bad bacteria from the mouth. First of all it was investigated whether chewing gum could trap and thereby remove bacteria from the mouth, as an important first step in the development of a chewing gum that specifically traps bad bacteria. Second, we did research on the possibilities to change the hydrophobicity of oral bacteria, used to specifically target certain types of oral bacteria. Herewith this thesis can form a framework for the development of the oral health benefits of chewing gum.
Genetic Variation in the Vesicular Monoamine Transporter: Preliminary Associations With Cognitive Outcomes After Severe Traumatic Brain Injury

Introduction: Traumatic brain injury (TBI) frequently results in impaired cognition, a function that can be modulated by monoaminergic signaling. Genetic variation among monoaminergic genes may affect post-TBI cognitive performance. The vesicular monoamine transporter-2 (VMAT2) gene may be a novel source of genetic variation important for cognitive outcomes post-TBI given VMAT2's role in monoaminergic neurotransmission. Objective: To evaluate associations between VMAT2 variability and cognitive outcomes post-TBI. Methods: We evaluated 136 white adults with severe TBI for variation in VMAT2 using a tagging single nucleotide polymorphism (tSNP) approach (rs363223, rs363226, rs363251, and rs363341). We show genetic variation interacts with assessed cognitive impairment (cognitive composite [Comp-Cog] T-scores) to influence functional cognition (functional independence measure cognitive [FIM-Cog] subscale] 6 and 12 months postinjury. Results: Multivariate analyses at 6 months postinjury showed rs363226 genotype was associated with Comp-Cog (P = .040) and interacted with Comp-Cog to influence functional cognition (P < .001). G-homozygotes had the largest cognitive impairment, and their cognitive impairment had the greatest adverse effect on functional cognition. Discussion: We provide the first evidence that genetic variation within VMAT2 is associated with cognitive outcomes after TBI. Further work is needed to validate this finding and elucidate mechanisms by which genetic variation affects monoaminergic signaling, mediating differences in cognitive outcomes.
Atypical audiovisual temporal function in autism and schizophrenia: similar phenotype, different cause

Binding across sensory modalities yields substantial perceptual benefits, including enhanced speech intelligibility. The coincidence of sensory inputs across time is a fundamental cue for this integration process. Recent work has suggested that individuals with diagnoses of schizophrenia (SZ) and autism spectrum disorder (ASD) will characterize auditory and visual events as synchronous over larger temporal disparities than their neurotypical counterparts. Namely, these clinical populations possess an enlarged temporal binding window (TBW). Although patients with SZ and ASD share aspects of their symptomatology, phenotypic similarities may result from distinct etiologies. To examine similarities and variances in audiovisual temporal function in these two populations, individuals diagnosed with ASD (n = 46; controls n = 40) and SZ (n = 16, controls = 16) completed an audiovisual simultaneity judgment task. In addition to standard psychometric analyses, synchrony judgments were assessed using Bayesian causal inference modeling. This approach permits distinguishing between distinct causes of an enlarged TBW: an a priori bias to bind sensory information and poor fidelity in the sensory representation. Findings indicate that both ASD and SZ populations show deficits in multisensory temporal acuity. Importantly, results suggest that while the wider TBWs in ASD most prominently results from atypical priors, the wider TBWs in SZ results from a trend toward changes in prior and weaknesses in the sensory representations. Results are discussed in light of current ASD and SZ theories and highlight that different perceptual training paradigms focused on improving multisensory integration may be most effective in these two clinical populations and emphasize that similar phenotypes may emanate from distinct mechanistic causes.
Observation of a peaking structure in the J /ψφ mass spectrum from B ± → J /ψφ K ± decays

A peaking structure in the J /ψφ mass spectrum near threshold is observed in B ± → J /ψφ K ± decays, produced in pp collisions at √ s = 7 TeV collected with the CMS detector at the LHC. The data sample, selected on the basis of the dimuon decay mode of the J /ψ , corresponds to an integrated luminosity of 5.2 fb − 1 . Fitting the structure to an S -wave relativistic Breit–Wigner lineshape above a three-body phase-space nonresonant component gives a signal statistical signiﬁcance exceeding ﬁve standard deviations. The ﬁtted mass and width values are m = 4148 . 0 ± 2 . 4 ( stat. ) ± 6 . 3 ( syst. ) MeV and Γ = 28 + 15 − 11 ( stat. ) ± 19 ( syst. ) MeV, respectively. Evidence for an additional peaking structure at higher J /ψφ mass is also reported.
Using Support Vector Machine on EEG for Advertisement Impact Assessment

The advertising industry depends on an effective assessment of the impact of advertising as a key performance metric for their products. However, current assessment methods have relied on either indirect inference from observing changes in consumer behavior after the launch of an advertising campaign, which has long cycle times and requires an ad campaign to have already have been launched (often meaning costs having been sunk). Or through surveys or focus groups, which have a potential for experimental biases, peer pressure, and other psychological and sociological phenomena that can reduce the effectiveness of the study. In this paper, we investigate a new approach to assess the impact of advertisement by utilizing low-cost EEG headbands to record and assess the measurable impact of advertising on the brain. Our evaluation shows the desired performance of our method based on user experiment with 30 recruited subjects after watching 220 different advertisements. We believe the proposed SVM method can be further developed to a general and scalable methodology that can enable advertising agencies to assess impact rapidly, quantitatively, and without bias.