Miracle-dz/UniFAR-FTUs huggingface dataset:
Influence of TP53 Codon 72 Polymorphism Alone or in Combination with HDM2 SNP309 on Human Infertility and IVF Outcome

To evaluate the association of the TP53 codon 72 (rs 1042522) alone or in combination with HDM2 SNP309 (rs 2279744) polymorphisms with human infertility and IVF outcome, we collected 1450 infertility women undergoing their first controlled ovarian stimulation for IVF treatment and 250 fertile controls in the case-control study. Frequencies, distribution, interaction of genes, and correlation with infertility and IVF outcome of clinical pregnancy were analyzed. We found a statistically significant association between TP53 codon 72 polymorphism and IVF outcome (52.10% vs. 47.40%, OR = 0.83, 95%CI:0.71–0.96, p = 0.01). No significant difference was shown between TP53 codon 72, HDM2 SNP309 polymorphisms, human infertility, and between the combination of two genes polymorphisms and the clinical pregnancy outcome of IVF. The data support C allele as a protective factor for IVF pregnancy outcome. Further researches should be focused on the mechanism of these associations.
Increased expression of nerve growth factor correlates with visceral hypersensitivity and impaired gut barrier function in diarrhoea‐predominant irritable bowel syndrome: a preliminary explorative study

Neural‐immune‐endocrine network mechanism has attracted increased attention in diarrhoea‐predominant irritable bowel syndrome (IBS‐D). Pre‐clinical evidence indicates that nerve growth factor (NGF) mediates visceral hypersensitivity and gut barrier dysfunction, via interactions with mast cells and sensory nerve fibres.
Scaling in the relaxation of supercooled liquids.

We have measured the dielectric susceptibility of several glass-forming liquids over 13 decades of frequency. The primary relaxation for all the liquids, over the entire frequency and temperature range studied, can be collapsed onto a single scaling curve with only two parameters, peak position and width. This curve is different from any of the theoretical forms suggested in the literature. The relaxation evolves smoothly from Debye behavior at high temperature
Glucose sensing and signalling properties in Saccharomyces cerevisiae require the presence of at least two members of the glucose transporter family

The kinetics of glucose transport in a number of different mutants of Saccharomyces cerevisiae with multiple deletions in the glucose transporter gene family were determined. The deletions led to differences in maximal rate and affinity for glucose uptake by the cells, dependent on the growth conditions. At the same time, there were changes in glucose repression, as determined by expression of invertase activity. Only in the strain with genes HXT1-4 and SNF3 deleted but carrying HXT6/7 were glucose uptake kinetics and invertase activity independent of the presence or concentration of glucose in the growth medium. Some degree of glucose sensitivity was recovered if the SNF3 or HXT2 gene was present in the multiple-deletion background. It is hypothesized that during growth on glucose, both modulation of the kinetics of glucose uptake and derepression of invertase activity require the presence of more than one active gene of the glucose transporter family.
Chemokine-Enhanced Chemotaxis of Lymphangioleiomyomatosis Cells with Mutations in the Tumor Suppressor TSC2 Gene1

Lymphangioleiomyomatosis (LAM) is characterized by cystic lung destruction caused by LAM cells (smooth-muscle-like cells) that have mutations in the tumor suppressor genes tuberous sclerosis complex (TSC) 1 or 2 and have the capacity to metastasize. Since chemokines and their receptors function in chemotaxis of metastatic cells, we hypothesized that LAM cells may be recruited by chemokine(s) in the lung. Quantification of 25 chemokines in bronchoalveolar lavage fluid from LAM patients and healthy volunteers revealed that concentrations of CCL2, CXCL1, and CXCL5 were significantly higher in samples from LAM patients than those from healthy volunteers. In vitro, CCL2 or MCP-1 induced selective migration of cells, showing loss of heterozygosity of TSC2 from a heterogeneous population of cells grown from explanted LAM lungs. Additionally, the frequencies of single-nucleotide polymorphisms in the CCL2 gene promoter region differed significantly in LAM patients and healthy volunteers (p = 0.018), and one polymorphism was associated significantly more frequently with the decline of lung function. The presence (i.e., potential functionality) of chemokine receptors was evaluated using immunohistochemistry in lung sections from 30 LAM patients. Expression of chemokines and these receptors varied among LAM patients and differed from that seen in some cancers (e.g., breast cancer and melanoma cells). These observations are consistent with the notion that chemokines such as CCL2 may serve to determine mobility and specify the site of metastasis of the LAM cell.
Learning to become a teacher in the 21st century: ICT integration in Initial Teacher Education in Chile

This paper presents the most relevant results from a national study about the availability and use of ICT in 46 Initial Teacher Education institutions in Chile, implemented during 2009 as part of the OECD (Organization for Economic Cooperation and Development) international project "ICT in Initial Teacher Training. " Main findings show an overall favorable context for the pedagogical use of ICT in such institutions, in terms of ICT infrastructure, support, policies and teachers' self-reported ICT related skills. In addition, teachers report a quite frequent use of some ICT resources, giving a high importance to students' learning of ICT. However, ICT integration is limited to a few specific resources (mainly computers and projectors), mostly applied to perform "traditional" pedagogical activities. Therefore, the expectations about the improvement of teaching and learning in Teacher Education in Chile through the integration of ICT, are not been fulfilled yet. This paper can constitute a significant contribution for developing more innovative and better quality pedagogical practices in this education level.
Outer bounds for user cooperation

We obtain a dependence balance based outer bound on the capacity region of the two-user multiple access channel with generalized feedback (MAC-GF). We investigate a Gaussian MAC with user-cooperation (MAC-UC), where each transmitter receives an additive white Gaussian noise corrupted version of the channel input of the other transmitter. For all non-zero values of cooperation noise variances, our outer bound strictly improves upon the cut-set outer bound. Moreover, as the variances of the cooperation noises become large, our outer bound collapses to the capacity region of the Gaussian MAC without cooperation.
International Banking and the Allocation of Risk

Macroeconomic risks could magnify individual bank risk. Mitigating the influence of economy-wide risks on banks could therefore be very important to maintain a smooth-running banking system. In this paper, we explore the extent to which macroeconomic risks affect banks. We use a bank-level dataset on over 2,000 banks worldwide for the years 1995-2002 to study the effect of macroeconomic volatility, the openness of the banking system, and banking regulations on bank risks. Our measure of bank risk is the volatility of banks’ pretax profits. We find that macroeconomic volatility increases banks’ profit volatility and that international openness of the banking system lowers bank risk. We find no impact of banking regulation on profit volatility. Our findings suggest that if policymakers want to lower bank risk, they should seek to lower macroeconomic volatility as well as increase openness in the banking system.
KONTRIBUSI POWER TUNGKAI DAN KECEPATAN REAKSI TERHADAP TENDANGAN MAE GERI PADA ATLET KARATE PUTRI

Penelitian ini bertujuan Untuk mengetahui kontribusi antara power tungkai terhadap hasil tendangan mae geri pada atlet putri bintang jaya mandiri tanjung bintang. Jenis penelitian yang digunakan adalah deskriptif korelasional dengan sampel sebanyak 30 atlet putri. teknik pengumpulan data menggunakan tes dan pengukuran. Hasil penelitian dan analisis menunjukkan rata-rata hasil pengukuran power tungkai atlet putri adalah 2,19, kecepatan reaksi 59,73, kemampuan tendangan mae geri 0,267. Hasil penelitian dapat disimpulkan bahwa power tungkai memberikan kontribusi terhadap tendangan mae geri sebesar 14,60% pada atlet karate putri bintang jaya mandiri Tanjung Bintang. Kecepatan Reaksi memberikan komtribusi terhadap tendangan mae geri sebesar 18,7% pada atlet karate putri bintang jaya mandiri Tanjung Bintang.ABSTRACTThis study aims to find out the contribution between power limbs to the results of the mae geri kick on the independent jaya star athlete Tanjung Bintang. The type of research used is descriptive correlational with a sample of 30 female athletes. data collection techniques using tests and measurements. The results of the study and analysis showed that the average results of the measurement of female athlete's limb strength were 2.19, reaction speed of 59.73, the ability to shoot the mae geri 0.267. The results of the study concluded that the limb power contributed to the mae geri kick of 14.60% in female karate athletes in the independent Jaya star Tanjung Bintang. Reaction Speed gives contribution to mae geri kicks in the amount of 18.7% in female karate athletes independent jaya star Tanjung Bintang.Keywords: karate, contribution of leg power, speed of reaction, mae geri kicks
How does disk gravity really influence type-I migration?

We report an analytical expression for the locations of Lindblad resonances induced by a perturbing protoplanet, including the effect of disk gravity. Inner, outer and differential torques are found to be enhanced compared to situations where a keplerian velocity field for the dynamics of both the disk and the planet is assumed. Inward migration is strongly accelerated when the disk gravity is only accounted for in the planet orbital motion. The addition of disk self-gravity slows down the planet drift but not enough to stop it.
Bronchodilator response cut-off points and FEV 0.75 reference values for spirometry in preschoolers

ABSTRACT Objective: To determine the cut-off points for FEV1, FEV0.75, FEV0.5, and FEF25-75% bronchodilator responses in healthy preschool children and to generate reference values for FEV0.75. Methods: This was a cross-sectional community-based study involving children 3-5 years of age. Healthy preschool children were selected by a standardized questionnaire. Spirometry was performed before and after bronchodilator use. The cut-off point of the response was defined as the 95th percentile of the change in each parameter. Results: We recruited 266 children, 160 (60%) of whom were able to perform acceptable, reproducible expiratory maneuvers before and after bronchodilator use. The mean age and height were 57.78 ± 7.86 months and 106.56 ± 6.43 cm, respectively. The success rate for FEV0.5 was 35%, 68%, and 70% in the 3-, 4-, and 5-year-olds, respectively. The 95th percentile of the change in the percentage of the predicted value in response to bronchodilator use was 11.6%, 16.0%, 8.5%, and 35.5% for FEV1, FEV0.75, FEV0.5, and FEF25-75%, respectively. Conclusions: Our results provide cut-off points for bronchodilator responsiveness for FEV1, FEV0.75, FEV0.5, and FEF25-75% in healthy preschool children. In addition, we proposed gender-specific reference equations for FEV0.75. Our findings could improve the physiological assessment of respiratory function in preschool children.
Development of a novel, highly quantitative in vivo model for the study of biofilm‐impaired cutaneous wound healing

A growing body of evidence suggests that in addition to hypoxia, ischemia‐reperfusion injury, and intrinsic host factors, bacterial biofilms represent a fourth major pillar in chronic wound pathogenesis. Given that most studies to date rely on in vitro or observational clinical data, our aim was to develop a novel, quantitative animal model enabling further investigation of the biofilm hypothesis in vivo. Dermal punch wounds were created in New Zealand rabbit ears, and used as uninfected controls, or inoculated with green fluorescent protein‐labeled Staphylococcus aureus to form wounds with bacteria predominantly in the planktonic or biofilm phase. Epifluorescence and scanning electron microscopy revealed that S. aureus rapidly forms mature biofilm in wounds within 24 hours of inoculation, with persistence of biofilm viability over time seen through serial bacterial count measurement and laser scanning confocal imaging at different time points postwounding and inoculation. Inflammatory markers confirmed that the biofilm phenotype creates a characteristic, sustained, low‐grade inflammatory response, and that over time biofilm impairs epithelial migration and granulation tissue in‐growth, as shown histologically. We have established and validated a highly quantitative, reproducible in vivo biofilm model, while providing evidence that the biofilm phenotype specifically contributes to profound cutaneous wound healing impairment. Our model highlights the importance of bacterial biofilms in chronic wound pathogenesis, providing an in vivo platform for further inquiry into the basic biology of bacterial biofilm–host interaction and high‐throughput testing of antibiofilm therapeutics.
Determinants of Birth Weight: Does Air Pollution Have an Influential Effect?

To investigate the influence of air pollution on birth weight, information on maternal and infant characteristics was collected from 458 mothers of infants less than one year of age born in 1995 and under observation at a mother and child health center in Ankara. In addition, the obstetrical histories of 520 infants born in 1990 were collected from the delivery room records of a maternity hospital. Daily air pollution data were obtained and mean monthly values were used for statistical analysis. Among the possible risk factors, sex, maternal age, maternal employment, paternal employment and parity were found to be influential factors on low birth weight. In addition, first trimester sulphur dioxide (SO 2 ) and particulate matter (PM) levels were also found to be factors affecting birth weight. However, these effects were shown not to be statistically significant by logistic regression analysis. A comprasion of mean birth weights according to maternal smoking and exposure to passive smoking on the basis of the third trimester SO 2 and PM levels revealed no significant difference; however, the difference in birthweight of non-smoking mothers was higher than that of smoking mothers when the third trimester SO 2 levels were above the minimum effect level (100 g and 220 g, respectively). These findings led us to propose a synergistic effect of smoking and air pollution. It was concluded that, air pollution in Ankara is not on its own a major risk factor for low birth weight.
Behavioural evidence for a functional interaction between central 5‐HT2 and 5‐HT1A receptors

1 The possibility of 5‐HT2 receptor modulation of central 5‐HT1A receptor function has been examined using the 5‐hydroxytryptamine (5‐HT) behavioural syndrome induced by 5‐HT1A receptor active drugs in rats. 2 The 5‐HT2/5‐HT1C antagonist ritanserin (0.1–2 mg kg−1) increased the 5‐HT behavioural syndrome induced by submaximally effective doses of 8‐hydroxy‐2‐(di‐n‐propylamino)tetralin (8‐OH‐DPAT), 5‐methoxy‐N,N‐dimethyltryptamine (5‐MeODMT) and gepirone. 3 Pretreatment with the 5‐HT2/5‐HT1C antagonist ICI 170,809 (0.25–5 mg kg−1) also enhanced the behavioural syndrome induced by 8‐OH‐DPAT or 5‐MeODMT. 4 The 5‐HT2/α1‐adrenoceptor antagonist ketanserin in a low dose (0.25 mg kg−1) significantly increased the 5‐HT behavioural syndrome induced by 8‐OH‐DPAT or 5‐MeODMT, while in a higher dose (2.5 mg kg−1) this drug decreased the response. Experiments with prazosin indicate that the higher dose of ketanserin might reduce the 5‐HT behavioural syndrome through blockade of α1‐adrenoceptors. 5 Ritanserin and ICI 170,809 had no effect on apomorphine‐induced stereotypy or hyperactivity, indicating that these drugs do not produce non‐specific behavioural activation. 6 Ritanserin and ICI 170,809 inhibited quipazine‐induced wet dog shakes at doses similar to those enhancing the 5‐HT behavioural syndrome. 7 We suggest that ritanserin, ICI 170,809 and ketanserin enhance 5‐HT1A agonist‐induced behaviour through blockade of an inhibitory 5‐HT2 receptor regulating or coupled to 5‐HT1A receptor‐mediated function.
Caries frequency and distribution in an early medieval Avar population from Austria.

OBJECTIVE The aim of this study was to determine frequency and distribution of dental caries in an early medieval Avar population from Central Europe, namely Vienna. METHODS The evaluation of caries was carried out in an anthropological sample consisting of the remains of 136 individuals and included 2215 permanent teeth. Age and sex estimations were based on dental development and on skeletal ageing methods. The presence of dental caries was determined according to clinical aspects using a dental probe. RESULTS The frequency of ante mortem tooth loss in the sample was 23.8%; the total caries frequency was calculated as 14.9%. The highest caries rate was recorded in the second mandibular molar (34.6%). The most affected tooth surface was found to be the root with 12.7%, followed by the approximal surface with 8.6%, but only 7.7% of the occlusal surfaces were affected by caries. CONCLUSION This study revealed that Avars suffered from higher caries rates than most other medieval European populations, but experienced a similar dental caries distribution. Attrition of the occlusal surface resulting from a diet containing abrasive particles with accompanying posteruptive tooth movement is considered the major factor causing this premodern caries pattern.
Belirli koşul altındaki asal gamma halkalarının tek yanlı idealleri ve türevleri üzerine

Bu calismada, belirli kosul altinda M asal gamma halkasinin herhangi bir (d,k) turevi icin elde ettigimiz bazi sonuclar Bresar’ in [3] “One-sided Ideals and Derivations of Prime Rings” adli makalesine paralel olarak verilmistir. Bresar makalesin de R asal halka, d, R halkasinin bir turevi ve U, R halkasinin bir sag ideali olmak uzere, d(U)U=0 kosulu varken qU=0 olacak sekilde bazi q Q icin, d(x)=[q,x]=qx-xq oldugunu ifade etmis ve daha sonraki bazi teoremlerde bu ozellikten faydalanmistir. Bu makalede benzer karekterizasyonlar asal gamma halkalar icin elde edilmeye calisilmistir.
Putting the Acute Coronary Syndrome in Context After 80 Years of Age.

Cardiovascular disease plays a major role in morbidity, mortality, and quality of life of older adults, yet this population is underrepresented in clinical studies, thereby leaving important evidence gaps.1 Guidelines recommend an initial invasive strategy for patients with high-risk acute coronary syndromes (ACS), including those ≥75 years of age,2 yet the risks and benefits of this approach are unclear in the oldest patients. Seeking to address this gap, the recently published After Eighty clinical trial randomly assigned patients ≥80 years of age who presented with non–ST-elevation ACS at 16 hospitals in Norway to an invasive strategy (coronary angiography and percutaneous coronary intervention/coronary artery bypass grafting with optimal medical therapy) or a conservative strategy (optimal medical therapy alone). 3 Patients were followed for a mean of 1.53 years for the primary composite outcome of death, myocardial infarction (MI), stroke, or urgent revascularization, which occurred in 40.6% of the invasive group and 61.4% of the conservative group (hazard ratio 0.53; 95% confidence interval 0.41–0.69, P <0.0001). Low rates of bleeding confirmed the safety of this approach with radial access in these selected patients. However, in After Eighty, the overall benefit of the initial invasive approach was driven by reductions in MI and urgent revascularization, with death being similar (and prevalent) in both groups (≈25%). Moreover, compared with those 80 to 89 years of …
Internal Iliac Artery Stenosis: Diagnosis and How to Manage it in 2015

Lower extremity arterial disease (LEAD) is a highly prevalent disease affecting 202 million people worldwide. Internal iliac artery stenosis (IIAS) is one of the localization of LEAD. This diagnosis is often neglected when a patient has a proximal walking pain since most physicians evoke a pseudoclaudication. Surprisingly, IIAS management is reported neither in the Trans-Atlantic Inter-Society Consensus II nor in the report of the American College Foundation/American Heart Association guidelines. The aims of this review are to present the current knowledge about the disease, how should it be managed in 2015 and what are the future research trends.
Rapid determination of earthquake magnitude using GPS for tsunami warning systems

The 26 December 2004 Sumatra earthquake (Mw 9.2–9.3) generated the most deadly tsunami in history. Yet within the first hour, the true danger of a major oceanwide tsunami was not indicated by seismic magnitude estimates, which were far too low (Mw 8.0–8.5). This problem relates to the inherent saturation of early seismic‐wave methods. Here we show that the earthquake's true size and tsunami potential can be determined using Global Positioning System (GPS) data up to only 15 min after earthquake initiation, by tracking the mean displacement of the Earth's surface associated with the arrival of seismic waves. Within minutes, displacements of >10 mm are detectable as far away as India, consistent with results using weeks of data after the event. These displacements imply Mw 9.0 ± 0.1, indicating a high tsunami potential. This suggests existing GPS infrastructure could be developed into an effective component of tsunami warning systems.
Direct, Interferon-Independent Activation of the CXCL10 Promoter by NF-κB and Interferon Regulatory Factor 3 during Hepatitis C Virus Infection

ABSTRACT Hepatitis C virus (HCV) infection of hepatocytes leads to transcriptional induction of the chemokine CXCL10, which is considered an interferon (IFN)-stimulated gene. However, we have recently shown that IFNs are not required for CXCL10 induction in hepatocytes during acute HCV infection. Since the CXCL10 promoter contains binding sites for several proinflammatory transcription factors, we investigated the contribution of these factors to CXCL10 transcriptional induction during HCV infection in vitro. Wild-type and mutant CXCL10 promoter-luciferase reporter constructs were used to identify critical sites of transcriptional regulation. The proximal IFN-stimulated response element (ISRE) and NF-κB binding sites positively regulated CXCL10 transcription during HCV infection as well as following exposure to poly(I·C) (a Toll-like receptor 3 [TLR3] stimulus) and 5′ poly(U) HCV RNA (a retinoic acid-inducible gene I [RIG-I] stimulus) from two viral genotypes. Conversely, binding sites for AP-1 and CCAAT/enhancer-binding protein β (C/EBP-β) negatively regulated CXCL10 induction in response to TLR3 and RIG-I stimuli, while only C/EBP-β negatively regulated CXCL10 during HCV infection. We also demonstrated that interferon-regulatory factor 3 (IRF3) is transiently recruited to the proximal ISRE during HCV infection and localizes to the nucleus in HCV-infected primary human hepatocytes. Furthermore, IRF3 activated the CXCL10 promoter independently of type I or type III IFN signaling. The data indicate that sensing of HCV infection by RIG-I and TLR3 leads to direct recruitment of NF-κB and IRF3 to the CXCL10 promoter. Our study expands upon current knowledge regarding the mechanisms of CXCL10 induction in hepatocytes and lays the foundation for additional mechanistic studies that further elucidate the combinatorial and synergistic aspects of immune signaling pathways.