Miracle-dz/UniFAR-FTUs huggingface dataset:
TMEM43 Mutation p.S358L Alters Intercalated Disc Protein Expression and Reduces Conduction Velocity in Arrhythmogenic Right Ventricular Cardiomyopathy

Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a myocardial disease characterized by fibro-fatty replacement of myocardium in the right ventricular free wall and frequently results in life-threatening ventricular arrhythmias and sudden cardiac death. A heterozygous missense mutation in the transmembrane protein 43 (TMEM43) gene, p.S358L, has been genetically identified to cause autosomal dominant ARVC type 5 in a founder population from the island of Newfoundland, Canada. Little is known about the function of the TMEM43 protein or how it leads to the pathogenesis of ARVC. We sought to determine the distribution of TMEM43 and the effect of the p.S358L mutation on the expression and distribution of various intercalated (IC) disc proteins as well as functional effects on IC disc gap junction dye transfer and conduction velocity in cell culture. Through Western blot analysis, transmission electron microscopy (TEM), immunofluorescence (IF), and electrophysiological analysis, our results showed that the stable expression of p.S358L mutation in the HL-1 cardiac cell line resulted in decreased Zonula Occludens (ZO-1) expression and the loss of ZO-1 localization to cell-cell junctions. Junctional Plakoglobin (JUP) and α-catenin proteins were redistributed to the cytoplasm with decreased localization to cell-cell junctions. Connexin-43 (Cx43) phosphorylation was altered, and there was reduced gap junction dye transfer and conduction velocity in mutant TMEM43-transfected cells. These observations suggest that expression of the p.S358L mutant of TMEM43 found in ARVC type 5 may affect localization of proteins involved in conduction, alter gap junction function and reduce conduction velocity in cardiac tissue.
Adverse effects of psychotherapy : Outcomes of a combined Internet treatment for Social Anxiety Disorder.

Social Anxiety Disorder (SAD) is a mental disorder with high prevalence but low treatment accessibility. A way to facilitate care to these patients is through Internet based treatment. As is the case of most psychological treatments, much has been studied about positive effects but there is a gap regarding adverse effects. This study seeks to fill this gap in the case of an Internet delivered treatment. From a total of 127 participants who took part in a treatment that combined attention biased modification (ABM) and Internet based cognitive behavior therapy (iCBT), 21 (16.5%) presented adverse effects. Most of the adverse effects were detected after participants had received iCBT (13.4%), and these were mostly related to deterioration of symptoms (5.5%), negative wellbeing (3.9%) and emergence of new symptoms (1.6%). Perceived side effects after attention training were less common (4.7%). A thematic analysis showed also that the techniques used in treatment, the lack of time to complete treatment and becoming aware with the impairments of the disorder and its consequences could influence the emergence of adverse effects.
RAPID applied to the SIM‐France model

SIM‐France is a large connected atmosphere/land surface/river/groundwater modelling system that simulates the water cycle throughout metropolitan France. The work presented in this study investigates the replacement of the river routing scheme in SIM‐France by a river network model called RAPID to enhance the capacity to relate simulated flows to river gauges and to take advantage of the automated parameter estimation procedure of RAPID. RAPID was run with SIM‐France over a 10‐year period and results compared with those of the previous river routing scheme. We found that while the formulation of RAPID enhanced the functionality of SIM‐France, the flow simulations are comparable in accuracy to those previously obtained by SIM‐France. Sub‐basin optimization of RAPID parameters was found to increase model efficiency. A single criterion for quantifying the quality of river flow simulations using several river gauges globally in a river network is developed that normalizes the square error of modelled flow to allow equal treatment of all gauging stations regardless of the magnitude of flow. The use of this criterion as the cost function for parameter estimation in RAPID allows better results than by increasing the degree of spatial variability in optimization of model parameters. Likewise, increased spatial variability of RAPID parameters through accounting for topography is shown to enhance model performance. Copyright © 2011 John Wiley & Sons, Ltd.
Tangential Interpolatory Projection for Model Reduction of Linear Quantum Stochastic Systems

This paper presents a model reduction method for the class of linear quantum stochastic systems often encountered in quantum optics and related fields. The approach is proposed on the basis of an interpolatory projection ensuring that specific input-output responses of the original and the reduced-order systems are matched at multiple selected points (or frequencies). Importantly, the physical realizability property of the original quantum system imposed by the laws of quantum mechanics is preserved under our tangential interpolatory projection. Error bounds are established for the proposed model reduction method and an avenue to select interpolation points is proposed. A passivity preserving model reduction method is also presented. Examples of both active and passive systems are provided to illustrate the merits of our proposed approach.
A 7 mW 20 MHz BW Time-Encoding Oversampling Converter Implemented in a 0.08 mm$^{2}$  65 nm CMOS Circuit

This work presents an area- and power-efficient realization of a new time-encoding oversampling converter (TEOC) consisting of a third-order continuous time (CT) loop filter and a self-oscillating pulse-width modulator (PWM). The modulator displays similar performance to that of a standard multibit CT-ΣΔ modulator but has the complexity of a single bit design. The time-encoding quantizer (TEQ) is implemented inside a ΣΔ modulator by replacing a multibit quantizer. An innovative TEQ is used to overcome design issues in a 1.0 V supply-voltage 65 nm digital CMOS technology. The TEQ allows an exchange of amplitude-resolution by time-resolution. The approach of time-resolution alleviates the scaling difficulties of mixed-signal circuits in nano-scale technologies. The TEOC features a 63 dB dynamic-range and a peak-SNDR of 61 dB over a 20 MHz signal bandwidth. Clocked at 2.5 GHz, the complete ADC consumes 7 mW from a single 1.0 V supply, including also the reference buffers. The ADC core results in an attractively small area of 0.08 mm2 and in a figure-of-merit (FoM=Pwr/2 · BW · 2ENOB) of 0.17 pJ/conversion-step.
Effect of Seed Position on Parental Plant on Proportion of Seeds Produced with Nondeep and Intermediate Physiological Dormancy

The position in which seeds develop on the parental plant can have an effect on dormancy-break and germination. We tested the hypothesis that the proportion of seeds with intermediate physiological dormancy (PD) produced in the proximal position on a raceme of Isatis violascens plants is higher than that produced in the distal position, and further that this difference is related to temperature during seed development. Plants were watered at 3-day intervals, and silicles and seeds from the proximal (early) and distal (late) positions of racemes on the same plants were collected separately and tested for germination. After 0 and 6 months dry storage at room temperature (afterripening), silicles and seeds were cold stratified for 0–16 weeks and tested for germination. Mean daily maximum and minimum temperatures during development/maturation of the two groups of seeds did not differ. A higher proportion of seeds with the intermediate level than with the nondeep level of PD was produced by silicles in the proximal position than by those in the distal position, while the proportion of seeds with nondeep PD was higher in the distal than in the proximal position of the raceme. The differences were not due only to seed mass. Since temperature and soil moisture conditions were the same during development of the seeds in the raceme, differences in proportion of seeds with intermediate and nondeep PD are attributed to position on parental plant. The ecological consequence of this phenomenon is that it ensures diversity in dormancy-breaking and germination characteristics within a seed cohort, a probable bet-hedging strategy. This is the first demonstration of position effects on level of PD in the offspring.
Pharmacokinetics of Tulathromycin in Healthy and Neutropenic Mice Challenged Intranasally with Lipopolysaccharide from Escherichia coli

ABSTRACT Tulathromycin represents the first member of a novel subclass of macrolides, known as triamilides, approved to treat bovine and swine respiratory disease. The objectives of the present study were to assess the concentration-versus-time profile of tulathromycin in the plasma and lung tissue of healthy and neutropenic mice challenged intranasally with lipopolysaccharide (LPS) from Escherichia coli O111:B4. BALB/c mice were randomly allocated into four groups of 40 mice each: groups T-28 (tulathromycin at 28 mg/kg of body weight), T-7, T7-LPS, and T7-LPS-CP (cyclophosphamide). Mice in group T-28 were treated with tulathromycin at 28 mg/kg subcutaneously (s.c.) (time 0 h). The rest of the mice were treated with tulathromycin at 7 mg/kg s.c. (time 0 h). Animals in dose groups T-7-LPS and T7-LPS-CP received a single dose of E. coli LPS intranasally at −7 h. Mice in group T7-LPS-CP were also rendered neutropenic with cyclophosphamide (150 mg/kg intraperitoneally) prior to the administration of tulathromycin. Blood and lung tissue samples were obtained from 5 mice from each dose group at each sampling time over 144 h after the administration of tulathromycin. There were not statistical differences in lung tissue concentrations among groups T-7, T-7-LPS, and T7-LPS-CP. For all dose groups, the distribution of tulathromycin in the lungs was rapid and persisted at relatively high levels during 6 days postadministration. The concentration-versus-time profile of tulathromycin in lung tissue was not influenced by the intranasal administration of E. coli LPS. The results suggest that in mice, neutrophils may not have a positive influence on tulathromycin accumulation in lung tissue when the drug is administered during either a neutrophilic or a neutropenic state.
Paraneoplastic Sensory Neuronopathy and Spontaneous Regression of Small Cell Lung Cancer

Background: Spontaneous tumour regression in small cell lung cancer has previously been suggested in patients with paraneoplastic neurologic syndromes. Rare documentation of this event has occurred in the literature. Case Report: The authors report a patient with anti-Hu associated paraneoplastic sensory neuronopathy who had a spontaneous regression of her small cell lung cancer. Conclusions: This case supports the hypothesis that anti-Hu neurologic syndromes are the consequence of a misdirected immune response to small cell tumours.
Breast response to menopausal hormone therapy—aspects on proliferation, apoptosis and mammographic density

Breast cancer is the major malignancy among women in the Western world. The breast is clearly a target organ for sex steroid hormones and hormonal treatments have been associated with an increased risk of breast cancer. The balance between proliferation and apoptosis is important for breast cell homeostasis. Mammographic breast density has been identified as a strong and independent risk factor for breast cancer. It seems clear that there is a difference between various hormonal treatments with regard to their effects on breast density and cell proliferation. Also, not all women respond similarly to the same treatment. Combined estrogen and progestogen therapy generally will enhance density and proliferation more than treatment with estrogen alone. Certain constitutional and hormonal factors appear to be predictive of breast reactivity. Older women with a low body mass index respond more strongly to treatment. Estrogen levels have a positive and androgens a negative association to increase in density and proliferation. A combination of increased proliferation and decreased apoptosis could be one mechanism to explain the excess risk of breast cancer during combined estrogen/progestogen treatment. Tibolone seems to have less impact on breast response than conventional hormone therapy. Efforts should be made to identify those women with an adverse response to treatment as well as therapeutic principles with the least possible influence on the breast.
Menstrual hygiene in Ugandan schools: an investigation of low-cost sanitary pads

Menstrual hygiene management (MHM) is a largely overlooked issue in the water, sanitation and hygiene (WASH) sector. Every day, millions of menstruating girls and women in low-income countries struggle to find clean water for washing, private places for changing and adequate blood absorbing materials. This study aims to explore the difficulties experienced by schoolgirls in Uganda in managing menstrual hygiene and investigates the extent to which low-cost sanitary pads are part of the solution. Low-cost sanitary pads, either re-usable or disposable, are a timely, simple and innovative means of improving menstrual hygiene and of addressing a broader set of problems related to MHM in schools. Other factors highlighted are: pain relief, education, safe water provision, clean and private latrines, hygienic and secure bathing facilities, use of soap, sealed waste disposal points, private drying places, anal cleansing materials and effective facility operation and management strategies.
Clinical, endoscopic and pathogical characteristics of early-onset colorectal cancer in Vietnamese.

BACKGROUND The Asia Pacific consensus for colorectal cancer (CRC) recommends that screening programs should begin by the age of 50. However, there have been reports about increasing incidence of CRC at a younger age (i.e. early-onset CRC). Little is known about the features of early-onset CRC in the Vietnamese population. AIM To describe the clinical, endoscopic and pathological characteristics of early-onset CRC in Vietnamese. METHOD A prospective, cross-sectional study was conducted at the University Medical Center from March 2009 to March 2011. All patients with definite pathological diagnosis of CRC were recruited. The early-onset CRC group were analyzed in comparison with the late-onset (i.e.≥50-year-old) CRC group. RESULTS The rate of early-onset CRC was 28% (112/400) with a male-to-female ratio of 1.3. Some 22.3% (25/112) of the patients only experienced abdominal pain and/or change in bowel habit without alarming symptoms, 42.9% (48/112) considering their symptoms intermittent. The rate of familial history of CRC in early-onset group was significantly higher that of the late-onset group (21.4% versus 7.6%, p<0.001). The distribution of CRC lesions in rectum, distal and proximal colon were 51.8% (58/112), 26.8% (30/112) and 21.4% (24/112), respectively; which was not different from that in the late-onset group (χ2, p=0.29). The rates for poorly differentiated tumors were also not significantly different between the two groups: 12.4% (14/112) versus 8.3% (24/288) (χ2, p=0.25). CONCLUSION A high proportion of CRC in Viet Nam appear at an earlier age than that recommended for screening by the Asia Pacific consensus. Family history was a risk factor of early-onset CRC. Diagnosis of early-onset CRC needs more attention because of the lack of alarming symptoms and their intermittent patterns as described by the patients.
Injectable hydrogel systems crosslinked by horseradish peroxidase

Hydrogels are widely used as reservoirs in drug delivery and scaffolds for tissue engineering. In particular, injectable hydrogel systems, which are formed by physical, chemical, or enzyme-mediated crosslinking reactions in situ, offer the advantages of minimal invasiveness, ease of application, and void-filling property. Examples of these hydrogels are provided in the first part of this paper. In the second part, hydrogels that are formed by the enzymatic activity of horseradish peroxidase (HRP) are highlighted. HRP catalyzes the crosslinking reaction of polymer-phenol conjugates in the presence of hydrogen peroxide (H2O2), resulting in hydrogels with tunable gelation rate and crosslinking density. The catalytic mechanism of the HRP-mediated crosslinking reaction is discussed in detail, and the recent biomedical applications of the HRP-crosslinked hydrogels are described. Lastly, the concerns associated with HRP-mediated crosslinking and the future outlook of HRP-crosslinked hydrogels are addressed.
Circadian Profiling of the Arabidopsis Proteome Using 2D-DIGE

Clock-generated biological rhythms provide an adaptive advantage to an organism, resulting in increased fitness and survival. To better elucidate the plant response to the circadian system, we surveyed protein oscillations in Arabidopsis seedlings under constant light. Using large-scale two-dimensional difference in gel electrophoresis (2D-DIGE) the abundance of more than 1000 proteins spots was reproducibly resolved quantified and profiled across a circadian time series. A comparison between phenol-extracted samples and RuBisCO-depleted extracts identified 71 and 40 rhythmically-expressed proteins, respectively, and between 30 and 40% of these derive from non-rhythmic transcripts. These included proteins influencing transcriptional regulation, translation, metabolism, photosynthesis, protein chaperones, and stress-mediated responses. The phasing of maximum expression for the cyclic proteins was similar for both datasets, with a nearly even distribution of peak phases across the time series. STRING clustering analysis identified two interaction networks with a notable number of oscillating proteins: plastid-based and cytosolic chaperones and 10 proteins involved in photosynthesis. The oscillation of the ABA receptor, PYR1/RCAR11, with peak expression near dusk adds to a growing body of evidence that intimately ties ABA signaling to the circadian system. Taken together, this study provides new insights into the importance of post-transcriptional circadian control of plant physiology and metabolism.
The Role of Rat Medial Frontal Cortex in Effort-Based Decision Making

We conducted a series of experiments to elucidate the role of rat medial frontal cortex (MFC) (including prelimbic, infralimbic, and cingulate cortices) in effort-based decision making. Rats were trained on a cost–benefit T-maze task in which they could either choose to climb a barrier to obtain a high reward in one arm (HR arm) or could obtain a small reward in the other with no barrier present (LR arm). Before surgery, all animals were selecting the HR arm on almost every trial. However, after excitotoxic lesions to MFC, the rats shifted to selecting the LR arm on almost every trial. This was not caused by a spatial memory or motor deficit because the same rats returned to selecting the HR arm when the amount of effort needed to be expended to obtain reward in either arm was equalized by putting an identical barrier in the LR arm. Additional experiments demonstrated that the change in effort-based decisions observed in the rats was not caused by a complete insensitivity to reward and effort because they returned to choosing the HR arm if either the cost was reduced (by making the barrier smaller) or the benefit was increased (increasing the food ratio differential). Instead, the MFC lesion shifted the animals' decision criterion, making them more likely to choose the LR arm than the sham-lesioned animals. These results imply that medial frontal cortex is important for allowing the animal to put in more work to obtain greater rewards.
Size at birth and insulin-like growth factor-I and its binding protein-1 among infants of diabetic mothers

Objective: to estimate the association between intrauterine fetal growth, evaluated by anthropometric measurements, and biochemical growth factors; IGF-I and IGBP-1 among IDMs. Methods: Cross-sectional study carried out on 69 full term IDMs who was admitted to neonatal intensive care units, Ain Shams University Hospitals. Clinical examination including anthropometric measurements; birth weight, length, head circumference, mid-arm circumference, skinfold thickness at triceps and subscapular areas and placental weight. Laboratory investigations included maternal HbA1c and cord blood IGF-I and IGBP-1. They were classified into three groups: 20 small for gestational age (SGA), 25 appropriate for gestational age (AGA) and 24 large for gestational age (LGA). Results: Most of SGA neonates were born to mothers with type I diabetes, while most of AGA and LGA were born to mothers with gestational diabetes. According to maternal HbA1c, SGA and LGA neonates were born to metabolically uncontrolled mothers while AGA neonates were born to well-controlled diabetic mothers. Anthropometric measurements had significant positive correlations with IGF-I and negative correlations with IGFBP-1. Conclusions: Good control of diabetes during pregnancy is essential to improve fetal growth. There is an opposing effect of cord blood IGF-I and IGFBP-1 on anthropometric measurements.
Firm Value, Risk, and Growth Opportunities

We show that Tobin's q, as proxied by the ratio of the firm's market value to its book value, increases with the firm's systematic equity risk and falls with the firm's unsystematic equity risk. Further, an increase in the firm's total equity risk is associated with a fall in q. The negative relation between the change in total risk and the change in q is robust through time for the whole sample, but it does not hold for the largest firms.
Adaptive Calibration of Channel Mismatches in Time-Interleaved ADCs Based on Equivalent Signal Recombination

In this paper, we present an adaptive calibration method for correcting channel mismatches in time-interleaved analog-to-digital converters (TIADCs). An equivalent signal recombination structure is proposed to eliminate aliasing components when the input signal bandwidth is greater than the Nyquist bandwidth of the sub-ADCs in a TIADC. A band-limited pseudorandom noise sequence is employed as the desired output of the TIADC and simultaneously is also converted into an analog signal, which is injected into the TIADC as the training signal during the calibration process. Adaptive calibration filters with parallel structures are used to optimize the TIADC output to the desired output. The main advantage of the proposed method is that it avoids a complicated error estimation or measurement and largely reduces the computational complexity. A four-channel 12-bit 400-MHz TIADC and its calibration algorithm are implemented by hardware, and the measured spurious-free dynamic range is greater than 76 dB up 90% of the entire Nyquist band. The hardware implementation cost can be dramatically reduced, especially in instrumentation or measurement equipment applications, where special calibration phases and system stoppages are common.