Miracle-dz/UniFAR-FTUs huggingface dataset:
MiG: Efficient Migration of Desktop VMs Using Semantic Compression

We consider the problem of efficiently migrating desktop virtual machines. The key challenge is to migrate the desktop VM quickly and in a bandwidth-efficient manner. The idea of replaying computation to reconstruct state seems appealing. However, our detailed analysis shows that the match between the source memory and the memory reconstructed via replay at the destination is poor, even at the subpage level; the ability to reconstruct memory state is stymied because modern OSes use address space layout randomization (ASLR) to improve security, and page prefetching to improve performance. Despite these challenges, we show that desktop VM memory state can be efficiently compressed for transfer without relying on replay, using a suite of semantic techniques - collectively dubbed as MiG - that are tailored to the type of each memory page. Our evaluation on Windows and Linux desktop VMs shows that MiG is able to compress the VM state effectively, requiring on average 51-65% fewer bytes to be transferred during migration compared to standard compression, and halving the migration time in a typical setting.
Ankle Syndesmotic Injury

Abstract Ankle syndesmotic injury does not necessarily lead to ankle instability; however, the coexistence of deltoid ligament injury critically destabilizes the ankle joint. Syndesmotic injury may occur in isolation or may be associated with ankle fracture. In the absence of fracture, physical examination findings suggestive of injury include ankle tenderness over the anterior aspect of the syndesmosis and a positive squeeze or external rotation test. Radiographic findings usually include increased tibiofibular clear space decreased tibiofibular overlap, and increased medial clear space. However, syndesmotic injury may not be apparent radiographically; thus, routine stress testing is necessary for detecting syndesmotic instability. The goals of management are to restore and maintain the normal tibiofibular relationship to allow for healing of the ligamentous structures of the syndesmosis. Fixation of the syndesmosis is indicated when evidence of a diastasis is present. This may be detected preoperatively, in the absence of fracture, or intraoperatively, after rigid fixation of the medial malleolus and fibula fractures. Failure to diagnose and stabilize syndesmotic disruption adversely affects outcome.
A New Formulation for FACTS Allocation for Security Enhancement against Voltage Collapse

This paper proposes a new formulation for var planning problems, including the allocation of FACTS devices. A new feature of the formulation lies in the treatment of security issues. Different from existing formulations, we directly take account of the expected cost for voltage collapse and corrective controls, in which the control effects by the devices to be installed are evaluated together with the other controls such as load shedding in contingencies to compute an optimal var planning. The inclusion of load shedding into the formulation guarantees the feasibility of the problem. The optimal allocation by the proposed method implies that the investment is optimized, taking into account its effects on security in terms of the cost for power system operation under possible events occurring probabilistically. The problem is formulated as a mixed integer nonlinear programming problem of a large dimension. The Benders decomposition technique is tested where the original problem is decomposed into multiple subproblems. The numerical examinations are carried out using AEP-14 bus system to demonstrate the effectiveness of the proposed method.
Innate Immune Recognition of Mycobacterium tuberculosis

Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB), is a major health problem, with 10 million new cases diagnosed each year. Innate immunity plays an important role in the host defense against M. tuberculosis, and the first step in this process is recognition of MTB by cells of the innate immune system. Several classes of pattern recognition receptors (PPRs) are involved in the recognition of M. tuberculosis, including Toll-like receptors (TLRs), C-type lectin receptors (CLRs), and Nod-like receptors (NLRs). Among the TLR family, TLR2, TLR4, and TLR9 and their adaptor molecule MyD88 play the most prominent roles in the initiation of the immune response against tuberculosis. In addition to TLRs, other PRRs such as NOD2, Dectin-1, Mannose receptor, and DC-SIGN are also involved in the recognition of M. tuberculosis. Human epidemiological studies revealed that genetic variation in genes encoding for PRRs and downstream signaling products influence disease susceptibility, severity, and outcome. More insight into PRRs and the recognition of mycobacteria, combined with immunogenetic studies in TB patients, does not only lead to a better understanding of the pathogenesis of tuberculosis but also may contribute to the design of novel immunotherapeutic strategies.
Elucidation of Acid-induced Unfolding and Aggregation of Human Immunoglobulin IgG1 and IgG2 Fc

Background: Monoclonal antibodies and Fc fusion proteins contain an IgG Fc moiety, which is associated with various degradation processes, including aggregation. Results: Fc unfolding is triggered by the protonation of acidic residues and depends on the IgG subclass and CH2 domain glycosylation. Conclusion: Fc aggregation in acidic conditions is determined by CH2 stability. Significance: Understanding Fc aggregation is important for improving the quality of Fc-based therapeutics. Understanding the underlying mechanisms of Fc aggregation is an important prerequisite for developing stable and efficacious antibody-based therapeutics. In our study, high resolution two-dimensional nuclear magnetic resonance (NMR) was employed to probe structural changes in the IgG1 Fc. A series of 1H-15N heteronuclear single-quantum correlation NMR spectra were collected between pH 2.5 and 4.7 to assess whether unfolding of CH2 domains precedes that of CH3 domains. The same pH range was subsequently screened in Fc aggregation experiments that utilized molecules of IgG1 and IgG2 subclasses with varying levels of CH2 glycosylation. In addition, differential scanning calorimetry data were collected over a pH range of 3–7 to assess changes in CH2 and CH3 thermostability. As a result, compelling evidence was gathered that emphasizes the importance of CH2 stability in determining the rate and extent of Fc aggregation. In particular, we found that Fc domains of the IgG1 subclass have a lower propensity to aggregate compared with those of the IgG2 subclass. Our data for glycosylated, partially deglycosylated, and fully deglycosylated molecules further revealed the criticality of CH2 glycans in modulating Fc aggregation. These findings provide important insights into the stability of Fc-based therapeutics and promote better understanding of their acid-induced aggregation process.
Anesthesia for an infant with Antley–Bixler syndrome

during craniosynostosis repair could allow a fatal asystole. Cushing’s reflex can be seen after skin closure. It has been recommended that ICP be recorded in cases of craniosynostosis as it helps in deciding whether patients should undergo surgery (10). Our observations have important repercussions for the clinical plan in craniosynostosis repair, including those in small children. It is imperative to assess subtle cardiovascular changes, in particular hypertension coupled with tachycardia/bradycardia, as quickly as possible in order to alert the surgeon. This case shows that seeking and identifying a Cushing reflex, together with continuous monitoring of arterial and ICP and surgical maneuvers is a reliable and valuable adjunct to existing monitoring techniques during craniosynostosis repair. In addition, this case is an example of brain herniation in the absence of clinical intracranial hypertension. Demet Dogan Erol M D Department of Anesthesiology and Reanimation, School of Medicine, Kocatepe University, Afyonkarahisar, Turkey (email: demetdoganerol@mynet.com)
Suberin: the biopolyester at the frontier of plants

Suberin is a lipophilic macromolecule found in specialized plant cell walls, wherever insulation or protection toward the surroundings is needed. Suberized cells form the periderm, the tissue that envelops secondary stems as part of the bark, and develop as the sealing tissue after wounding or leaf abscission. Suberin is a complex polyester built from poly-functional long-chain fatty acids (suberin acids) and glycerol. The suberin acids composition of a number of plant tissues and species is now established, but how the polyester macromolecule is assembled within the suberized cell walls is not known. In the last years contributions from several areas have however significantly enriched our understanding of suberin. The primary structure of the polyester, i.e., how the suberin acids and glycerol are sequentially linked was revealed, together with the stereochemistry of the mid-chain functional groups some suberin acids have; solid-state NMR studies showed the presence of methylene chains spatially separated and with different molecular mobility; biophysical studies showed the membrane behavior of suberin acids derivatives, allowing new insights on structure-properties relationships; and a number of candidate genes were conclusively related to suberin biosynthesis. The comprehension of suberin as a macromolecule will be essential to understand its vital protective roles in plants and how they will deal with eventual environmental changes. Suberin is also expected to be a source for high-performing bio-based chemicals, taking advantage of the structural uniqueness of their constituent suberin acids.
Matching with couples revisited

It is well known that a stable matching in a many-to-one matching market with couples need not exist. We introduce a new matching algorithm for such markets and show that for large random markets the algorithm will find a stable matching with high probability. In our model we allow the number of couples to grow at a near-linear rate. Furthermore, truth-telling is an approximated equilibrium in the game induced by the new matching algorithm. Our results are tight: for markets in which the number of couples grows at a linear rate, we show that with constant probability no stable matching exists.
Screen Space Foam Rendering

We present a method for the efficient rendering of large scale particle-based foam data in screen space using a GPU based rendering pipeline. Our approach employs a multi-pass rendering technique to imitate some of the effects that are commonly accomplished by using expensive ray-tracing based methods. We demonstrate through different scenarios that our pipeline is able to produce convincing foam renderings for large scale scenarios and it has a significant performance advantage compared to using ray-casting techniques for rendering such particle data.
Characterization of monoclonal antibodies reactive with Schistosoma haematobium-soluble egg and infected human urinary antigens.

Six murine monoclonal antibodies (MAbs) [Sh1/71.7 (IgM), Sh2/15.F (IgG1), Sh3/15.28 (IgG1), Sh3/38.2 (IgM), Sh4/14.3 (IgG1), and Sh5/32.30 (IgM)] produced against S. haematobium were extensively characterized. All the MAbs stained the surface membranes of miracidia as determined by the indirect fluorescent antibody test, yet three of them (Sh1/71.7, Sh3/15.28, and Sh3/38.2) also stained internal cytoplasmic antigens. Proteinase-K digestion and periodate oxidation studies showed that these three MAbs bound glycoprotein antigenic determinants, while the rest detected protein epitopes. Only Sh2/15.F, Sh3/15.28, and Sh4/14.3 could bind antigens with the western immunoblot assay. Sh2/15.F bound a 29-kDa antigen and Sh3/15.28 bound three antigen bands (53, 57, and 66 kDa) all in the soluble egg extract of an Egyptian strain of S. haematobium (SEAEgy), while Sh4/14.3 reacted with a 29-kDa antigen present in SEAEgy, as well as in the adult worm antigen extracts of Ghanaian strain(s) of S. haematobium and S. japonicum. Sh4/14.3 also bound a 78-kDa antigen in the S. japonicum worm. Cross-reactivity studies with S. haematobium, S. mansoni, S. japonicum, and Necator americanus revealed that Sh2/15.F and Sh3/15.28 were S. haematobium species-specific. Each of the remaining MAbs detected the three major human schistosomes without cross-reacting with N. americanus egg antigens. Three MAbs, Sh2/15.F, Sh4/14.3 and Sh5/32.30, could detect S. haematobium antigens in infected human urine.
Cytological Study of Palpable Breast Lumps with their Histological Correlation

Background: FNAC is an inexpensive and highly accurate means of diagnosing both benign and malignant breast lesions. The procedure provides a rapid and non-morbid diagnosis before the operation which enables the patient and the surgeon to discuss and plan therapeutic alternatives in a rational atmosphere. Objectives: To evaluate role of fine needle aspiration cytology in the diagnosis of breast lesions and to compare the cytological findings with the histopathology wherever possible. In addition the sensitivity, specificity and accuracy of FNAC in breast lesions are carried out. Material and Methods: The present study was carried out on 200 patients who presented with palpable lump in the breast in the Department of Pathology, Government Medical College, Patiala over a period of 2 years. Cytological Diagnosis was correlated with histological findings wherever possible. Results: Cytologically, the lesions were categorized into 4 major categories, benign 143 (71.5%), malignant 37 (18.5%), suspicious or atypical 10 (5%) and unsatisfactory 10 (5%). Out of these 200 cases, 85 cases (42.5%) were available for histopathological examination. The most common benign lesion in this study was fibroadenoma 23/52 (44.2%) and the most common malignant lesion was infiltrating ductal carcinoma (28/33) Diagnostic accuracy of FNAC for benign lesion was 94.2% while for malignant lesion, it was 96.7%. The sensitivity, specificity and overall diagnostic accuracy of FNAC came out to be 93.7%, 98.1% and 96.4% respectively. Conclusion : FNAC is a simple and reliable method for diagnosis of both benign and malignant lesions quite accurately thus reducing unnecessary surgeries. The present study proved that the procedure has high sensitivity, specificity and diagnostic accuracy. Though it cannot categorize the lesion in some cases but it can rule out malignancy in most of the cases. Considering its low cost and quick results, it can be a potential tool for screening of breast cancers.
Solution-focused brief therapy for Chilean primary care patients: Exploring a linguistic adaptation

ABSTRACT Solution-focused brief therapy (SFBT) is a resource-based, future-oriented therapeutic approach that focuses on finding exceptions to problems and identifying coping strategies to build solutions. SFBT has been efficacious with individuals with alcohol use disorders. Chile experiences high levels of alcohol consumption and alcohol-related health consequences. Despite the international dissemination of SFBT, this is the first study to attempt a linguistic adaptation of SFBT in a Latin American country. We conducted 9 cognitive interviews to examine 13 translated main SFBT tools and 3 focus groups to gather information on cultural aspects of alcohol use in primary care. Results suggest that Chileans understood most SFBT tools, albeit with some linguistic modifications of original translations, and that family, gender, and meaningful issues should be considered when working with individuals with alcohol use disorders.
TUMOR REGRESSIVE EFFECTS OF VISCUM ALBUM PREPARATIONS EXPLORATION OF IMMUNOMODULATORY MECHANISMS

Viscum album is a parasitic plant that grows on apple or pine trees. It is commonly known as Euro- pean mistletoe. Viscum album (VA) preparations are the aqueous extracts used as a complemen- tary medicine in cancer therapy. Various clinical studies have shown that VA preparations improve the quality of life in different cancer patients. Biologically active components of VA extracts include Mistletoe lectins (ML), viscotoxins, polyphenols and polysaccharides. The treatment with VA preparations or with purified ML has been shown to be associated with tumor regression in several in vivo experimental models of tumoral implantation. Various in vitro studies have shown the cytotoxic effects of VA preparations on various tumor cells. The mecha- nisms underlying the anti-tumoral activity of VA preparations or ML are complex and involve apoptosis, angio- genesis and immunomodulation. The immunomodulatory mechanisms mediated by the VA preparations can complement the anti-tumoral effects, resulting in effective tumor regression. This review provides an account of the current status of the understanding of the VA-associated immunomodulation in various cell types including lymphoblastoid, monocytic and endothelial cell lines.
Attacks on physical-layer identification

Physical-layer identification of wireless devices, commonly referred to as Radio Frequency (RF) fingerprinting, is the process of identifying a device based on transmission imperfections exhibited by its radio transceiver. It can be used to improve access control in wireless networks, revent device cloning and complement message authentication protocols. This paper studies the feasibility of performing impersonation attacks on the modulation-based and transient-based fingerprinting techniques. Both techniques are vulnerable to impersonation attacks; however, transient-based techniques are more difficult to reproduce due to the effects of the wireless channel and antenna in their recording process. We assess the feasibility of performing impersonation attacks by extensive measurements as well as simulations using collected data from wireless devices. We discuss the implications of our findings and how they affect current device identification techniques and related applications.
Generation Capacity Expansion in Imperfectly Competitive Restructured Electricity Markets

We consider three models of investments in generation capacity in restructured electricity systems that differ with respect to their underlying economic assumptions. The first model assumes a perfect, competitive equilibrium. It is very similar to the traditional capacity expansion models even if its economic interpretation is different. The second model (open-loop Cournot game) extends the Cournot model to include investments in new generation capacities. This model can be interpreted as describing investments in an oligopolistic market where capacity is simultaneously built and sold in long-term contracts when there is no spot market. The third model (closed-loop Cournot game) separates the investment and sales decision with investment in the first stage and sales in the second stage-that is, a spot market. This two-stage game corresponds to investments in merchant plants where the first-stage equilibrium problem is solved subject to equilibrium constraints. We show that despite some important differences, the open- and closed-loop games share many properties. One of the important results is that the prices and quantities produced in the closed-loop game, when the solution exists, fall between the prices and quantities in the open-loop game and the competitive equilibrium.
The Fitness Cost of Fluoride Resistance for Different Streptococcus mutans Strains in Biofilms

The cariogenic bacterium Streptococcus mutans can develop stable resistance to fluoride through chromosomal mutations in vitro. Fluoride-resistant S. mutans has seldom been isolated in clinical settings, despite the wide application of fluoride in oral-care products. One explanation is that the fluoride-resistant S. mutans strains have decreased fitness. However, so far, there has been no conclusive evidence to support this idea. The aim of this study was to investigate the fitness cost of 48-h biofilms of two fluoride-resistant S. mutans strains, UF35 and UA159-FR (UAFR), using the wild-type fluoride-sensitive strain UA159 as a reference. The engineered UF35 strain contains one point mutation, whereas UAFR, selected from NaF-containing agar plates, has multiple chromosomal mutations. All biofilms were formed for 48 h under a constantly neutral pH or a pH-cycling (8 h of neutral pH and 16 h of pH 5.5) condition in the absence of fluoride. The biomass of the biofilms was quantified with a crystal violet assay. The biofilms were also treated with chlorhexidine or solutions at pH 3.0, after which their lactic acid production was quantified. Compared to the UF35 and UA159 biofilms, the biomass of UAFR biofilms was two–four fold higher, and the UAFR biofilms were more resistant to chlorhexidine and low pH in terms of lactic acid production. No difference in biomass and lactic acid production was detected between UF35 and UA159 biofilms. The fluoride resistance of UAFR and UF35 strains in biofilms was further confirmed by treating the biofilms with NaF solutions. The level of NaF resistance of the three biofilms is generally ranked as follows: UAFR > UF35 > UA159. In conclusion, there is indeed a fitness consequence in UAFR, but surprisingly, this fluoride-resistant strain performs better than UF35 and UA159 under the described conditions. In addition, UF35 did not display a reduced fitness; it performed as well as the wild-type fluoride-sensitive strain.
Probabilistic Parsing of Unrestricted English Text, With a Highly-Detailed Grammar

Ezra Black, S t e p h e n Eubank, Hidek i Kashioka A T R I n t e r p r e t i n g T e l e c o m m u n i c a t i o n s Labora to r i e s 2-2 Hikar idai Seilm-cho, So raku-gun Kyoto, Japan 619-02 black@air, i~l. co. jp kashioka@a~r, itl. co. jp eub~-~@atr, itl. c o . jp David M a g e r m a n Renaissance Technologies Corp . 25 East Loop Road, Suite 211 Stony Brook , IVY 11776 U S A magermau~rencec, corn
Multilayered Mo-Doped TiO2 Nanofibers and Enhanced Photocatalytic Activity

One-dimensional nanostructures of multilayered Mo-doped TiO2 nanofibers with mesoporous structures are successfully synthesize form a hydrothermal process. Mo ions were incorporated into the crystal lattice of anatase TiO2 nanofibers, resulting in a noticeable red shift of the absorption edge and a significant enhancement of visible light absorption. There was different optimum Mo doping content for Mo-doped nanofibers to present the best visible and ultraviolet (UV) photocatalytic activity. The effect of the doping Mo as trapping centers on photocatalysis was investigated in detail and used to explain the difference between the photocatalysis under the illumination of visible and UV light.
Pandemic Influenza and Healthcare Demand in the Netherlands: Scenario Analysis

In accordance with World Health Organization guidelines, the Dutch Ministry of Health, Welfare and Sports designed a national plan to minimize effects of pandemic influenza. Within the scope of the Dutch pandemic preparedness plan, we were asked to estimate the magnitude of the problem in terms of the number of hospitalizations and deaths during an influenza pandemic. Using scenario analysis, we also examined the potential effects of intervention options. We describe and compare the scenarios developed to understand the potential impact of a pandemic (i.e., illness, hospitalizations, deaths), various interventions, and critical model parameters. Scenario analysis is a helpful tool for making policy decisions about the design and planning of outbreak control management on a national, regional, or local level.