Miracle-dz/UniFAR-FTUs huggingface dataset:
Boundary layer turbulence in transitional and developed states

Using the recent direct numerical simulations by Wu and Moin [“Transitional and turbulent boundary layer with heat transfer,” Phys. Fluids 22, 85 (2010)] of a flat-plate boundary layer with a passively heated wall, statistical properties of the turbulence in transition at Reθ ≈ 300, from individual turbulent spots, and at Reθ ≈ 500, where the spots merge (distributions of the mean velocity, Reynolds stresses, kinetic energy production, and dissipation rates, enstrophy and its components) have been compared to these statistical properties for the developed boundary layer turbulence at Reθ = 1840. When the distributions in the transitional regions are conditionally averaged so as to exclude locations and times when the flow is not turbulent, they closely resemble the distributions in the developed turbulent state at the higher Reynolds number, especially in the buffer layer. Skin friction coefficients, determined in this conditional manner at the two Reynolds numbers in the transitional flow are, of course,.
The 1/d Law of Giving

We combine survey data on friendship networks and individual characteristics with experimental observations from dictator games. Dictator offers are primarily explained by social distance, giving follows a simple inverse distance law. While student demographics play a minor role in explaining offer amounts, individual heterogeneity is important for network formation. In particular, we detect significant homophilous behavior; students connect to others similar to themselves. Moreover, the network data reveal a strong preference for cliques, students connect to those already close. The study is one of the first to identify network architecture with individual behavior in a strategic context. (JEL D44, H82)
Noninvasive and Quantitative Monitoring of Adult Neuronal Stem Cell Migration in Mouse Brain Using Bioluminescence Imaging

It is now generally accepted that continuous neurogenesis occurs in the adult mammalian brain, including that of humans. Modulation of adult neurogenesis can provide therapeutic benefits for various brain disorders, including stroke and Parkinson's disease. The subventricular zone‐olfactory bulb pathway is one of the preferred model systems by which to study neural stem cell proliferation, migration, and differentiation in adult rodent brain. Research on adult neurogenesis would greatly benefit from reliable methods for long‐term noninvasive in vivo monitoring. We have used lentiviral vectors encoding firefly luciferase to stably mark endogenous neural stem cells in the mouse subventricular zone. We show that bioluminescence imaging (BLI) allows quantitative follow‐up of the migration of adult neural stem cells into the olfactory bulb in time. Moreover, we propose a model to fit the kinetic data that allows estimation of migration and survival times of the neural stem cells using in vivo BLI. Long‐term expression of brain‐derived neurotrophic factor in the subventricular zone attenuated neurogenesis, as detected by histology and BLI. In vivo monitoring of the impact of drugs or genes on adult neurogenesis is now within reach.
MobiClique: middleware for mobile social networking

We consider a mobile ad hoc network setting where Bluetooth enabled mobile devices communicate directly with other devices as they meet opportunistically. We design and implement a novel mobile social networking middleware named MobiClique. MobiClique forms and exploits ad hoc social networks to disseminate content using a store-carry-forward technique. Our approach distinguishes itself from other mobile social software by removing the need for a central server to conduct exchanges, by leveraging existing social networks to bootstrap the system, and by taking advantage of the social network overlay to disseminate content. We also propose an open API to encourage third-party application development. We discuss the system architecture and three example applications. We show experimentally that MobiClique successfully builds and maintains an ad hoc social network leveraging contact opportunities between friends and people sharing interest(s) for content exchanges. Our experience also provides insight into some of the key challenges and short-comings that researchers face when designing and deploying similar systems.
Tissue Plasminogen Activator Antigen and D-Dimer as Markers for Atherothrombotic Risk Among Healthy Postmenopausal Women

Background—Plasma markers of fibrinolytic function are associated with incident coronary events among several, but not all, prospective epidemiologic investigations of healthy individuals. Few studies have evaluated this relationship in women. In addition, although menopausal hormone therapy (HT) may alter markers of fibrinolytic function, the relevance of this effect for coronary risk assessment has not been studied. Methods and Results—In a prospective, nested case-control study among 75 343 postmenopausal women without prior cardiovascular disease or cancer, we evaluated the relationships of elevated tissue plasminogen activator (tPA) antigen and D-dimer with subsequent first coronary heart disease events over a median period of 2.9 years. Baseline levels of both biomarkers were higher among 304 cases compared with 304 controls matched on age, smoking status, ethnicity, and length of follow-up; median values were 9.0 versus 7.4 ng/mL (P <0.001) for tPA antigen and 27.6 versus 23.4 ng/mL (P =0.001) for D-dimer. In matched-pairs analyses, the odds ratio in the highest versus lowest quartile of tPA antigen was 3.5 (95% CI, 2.1 to 5.8; P trend <0.001) and for D-dimer was 2.0 (95% CI, 1.2 to 3.2; P trend=0.005). After adjustment for lipid and nonlipid risk factors, including C-reactive protein, tPA antigen remained a significant predictor. Multivariable-adjusted associations for D-dimer, although attenuated, largely remained statistically significant. When stratified by HT, the relationship between tPA antigen and incident coronary heart disease was similar among nonusers, estrogen-only users, and current users of any HT. Conclusions—Elevated tPA antigen and, to a lesser extent, D-dimer are independently associated with incident coronary events among postmenopausal women. In analyses stratified by HT, tPA antigen remained a consistent marker of increased coronary risk.
Study on the Framework of e-Government Services Capability

Enhancement of the effectiveness and efficiency of e-government services (EGS) is critical to better meeting the increasing public demands for services. One of the better solutions to meet such demands is improving the government’s EGS capability (EGSC). However, few studies discuss the issues. The purpose of this study was to employ capability management perspectives to develop theoretical linkages and path relationships among the components of EGSC. Comprehensive validation was further conducted through path analysis (PA) using structural equation modeling methods based on the data collected from 102 cities of the 26 provinces in Mainland China. The study unveiled the structure of EGSC, and PA results provided government policy makers or information technology managers insight into enhancing EGSC through the improvement of the components’ performance.
Jun Kinase Delays Caspase-9 Activation by Interaction with the Apoptosome*

Activation of c-Jun N-terminal kinase 1/2 (JNK) can delay oxidant-induced cell death, but the mechanism is unknown. We found that oxidant stress of cardiac myocytes activated both JNK and mitochondria-dependent apoptosis and that expression of JNK inhibitory mutants accelerated multiple steps in this pathway, including the cleavage and activation of caspases-3 and -9 and DNA internucleosomal cleavage, without affecting the rate of cytochrome c release; JNK inhibition also increased caspase-3 and -9 cleavage in a cell-free system. On activation by GSNO or H2O2, JNK formed a stable association with oligomeric Apaf-1 in a ∼1.4–2.0 mDa pre-apoptosome complex. Formation of this complex could be triggered by addition of cytochrome c and ATP to the cell-free cytosol. JNK inhibition abrogated JNK-Apaf-1 association and accelerated the association of procaspase-9 and Apaf-1 in both intact cells and cell-free extracts. We conclude that oxidant-activated JNK associates with Apaf-1 and cytochrome c in a catalytically inactive complex. We propose that this interaction delays formation of the active apoptosome, promoting cell survival during short bursts of oxidative stress.
Closed Form Solutions for Nonuniform Transmission Lines

In this paper, three analytic closed form solutions are introduced for arbitrary Nonuniform Transmission Lines (NTLs). The differential equations of NTLs are written in three suitable matrix equation forms, first. Then the matrix equations are solved to obtain the chain parameter matrix of NTLs. The obtained solutions are applicable to arbitrary lossy and dispersive NTLs. The validation of the proposed solutions is verified using some comprehensive examples.
Sinusoidal echo‐planar imaging with parallel acquisition technique for reduced acoustic noise in auditory fMRI

To extend the parameter restrictions of a silent echo‐planar imaging (sEPI) sequence using sinusoidal readout (RO) gradients, in particular with increased spatial resolution. The sound pressure level (SPL) of the most feasible configurations is compared to conventional EPI having trapezoidal RO gradients.
Evidence that translation of smooth muscle alpha‐actin mRNA is delayed in the chick promyocardium until fusion of the bilateral heart‐forming regions

Heart development in the chick embryo proceeds from bilateral mesodermal primordia established during gastrulation. These primordia migrate to the midline and fuse into a single heart trough. During their migration as a cohesive sheet, the cells of the paired heart fields become epithelial and undergo cardiac differentiation, exhibiting organized myofibrils and rhythmic contractions near the time of their fusion. Between the stages of cardiomyoblast commitment and overt differentiation of cardiomyocytes, a significant time interval exists. Using a new riboprobe (usmaar) for whole‐mount in situ hybridization in chick embryos, we report the earliest phases of smooth muscle alpha‐actin (smaa) mRNA distribution during the precontractile developmental window. We show that ingressed heart‐forming regions express smaa by the head‐process stage (Hamburger and Hamilton stage 5). In addition, we used usmaar to study the formation and early morphogenesis of the heart. Consistent with fate mapping studies (Garcia‐Martinez and Schoenwolf [ 1993 ] Dev. Biol. 159:706–719; Schoenwolf and Garcia‐Martinez [ 1995 ] Cell Mol. Biol. Res. 41:233–240; Garcia‐Martinez et al., in preparation), our results with this probe, combined with detailed histological and SEM analyses of the so‐called cardiac crescent, demonstrate unequivocally that the heart arises from separated and paired heart rudiments, rather than from a single crescent‐shaped rudiment (that is, prior to fusion of the paired heart rudiments to establish the straight‐heart tube, the rostral midline of the cardiac crescent lacks mesodermal cells and consequently fails to label with usmaar). Smaa is also expressed in the splanchnic and somatic mesoderm, marking the earliest step in coelom formation. Consequently, we also used usmaar to describe formation of the pericardium. Finally, we provide evidence of a post‐transcriptional level of control of smaa gene expression in the heart fields. Our results suggest that the expression of smaa may mark a primitive mesodermal state from which definitive cell types can be derived through inductive events. Dev Dyn;218:316–330. © 2000 Wiley‐Liss, Inc.
Regulation and Levels of the Thylakoid K+/H+ Antiporter KEA3 Shape the Dynamic Response of Photosynthesis in Fluctuating Light

Crop canopies create environments of highly fluctuating light intensities. In such environments, photoprotective mechanisms and their relaxation kinetics have been hypothesized to limit photosynthetic efficiency and therefore crop yield potential. Here, we show that overexpression of the Arabidopsis thylakoid K+/H+ antiporter KEA3 accelerates the relaxation of photoprotective energy-dependent quenching after transitions from high to low light in Arabidopsis and tobacco. This, in turn, enhances PSII quantum efficiency in both organisms, supporting that in wild-type plants, residual light energy quenching following a high to low light transition represents a limitation to photosynthetic efficiency in fluctuating light. This finding underscores the potential of accelerating quenching relaxation as a building block for improving photosynthetic efficiency in the field. Additionally, by overexpressing natural KEA3 variants with modification to the C-terminus, we show that KEA3 activity is regulated by a mechanism involving its lumen-localized C-terminus, which lowers KEA3 activity in high light. This regulatory mechanism fine-tunes the balance between photoprotective energy dissipation in high light and maximum quantum yield in low light, likely to be critical for efficient photosynthesis in fluctuating light conditions.
All-optical logic NOR gate using two-cascaded semiconductor optical amplifiers

The authors present a novel all-optical logic NOR gate using two-cascaded semiconductor optical. amplifiers (SOAs) in a counterpropagating feedback configuration. This configuration accentuates the gain nonlinearity due to the mutual gain modulation of the two SOAs. The all-optical NOR gate feasibility has been demonstrated delivering an extinction ratio higher than 12 dB over a wide range of wavelength.
M\"obius transformations and the Poincar\'e distance in the quaternionic setting

In the space $\hh$ of quaternions, we investigate the natural, invariant geometry of the open, unit disc $\Delta_{\hh}$ and of the open half-space $\hh^{+}$. These two domains are diffeomorphic via a Cayley-type transformation. We first study the geometrical structure of the groups of M\"obius transformations of $\Delta_{\hh}$ and $\hh^{+}$ and identify original ways of representing them in terms of two (isomorphic) groups of matrices with quaternionic entries. We then define the cross-ratio of four quaternions, prove that, when real, it is invariant under the action of the M\"obius transformations, and use it to define the analogous of the Poincar\'e distances on $\Delta_{\hh}$ and $\hh^{+}$. We easily deduce that there exists no isometry between the quaternionic Poincar\'e distance of $\Delta_{\hh}$ and the Kobayashi distance inherited by $\Delta_{\hh}$ as a domain of $\mathbb{C}^{2}$, in accordance with a direct consequence of the classification of the non compact, rank 1, symmetric spaces.
Thermal evaporation synthesis of SiC/SiOx nanochain heterojunctions and their photoluminescence properties

Core–shell SiC/SiOx nanochain heterojunctions have been successfully synthesized on silicon substrate via a simplified thermal evaporation method at 1500 °C without using catalyst, template or flowing gases (Ar, CH4, N2, etc.). X-ray diffraction, field emission scanning electron microscopy, transmission electron microscopy combined with energy-dispersive X-ray spectroscopy, scanning transmission electron microscopy and Fourier-transform infrared spectroscopy are used to characterize the phase composition, morphology, and microstructure of the as-synthesized nanostructures. A combined vapor–solid growth and modulation procedure is proposed for the growth mode of the as-grown SiC/SiOx nanochains. The formation of SiOx beads not only relates to the Rayleigh instability and the poor wettability between SiC and SiOx, but also to the existence of a high density of stacking faults within SiC-core nanowires. The photoluminescence spectrum of the nanochains exhibits a significant blue shift, which can be highly valuable for future potential applications in blue-green emitting devices.
Detection and prevention of NSAID-induced enteropathy.

Non-steroidal anti-inflammatory drugs (NSAIDs) may cause damage distal to the duodenum. We reviewed the prevalence, clinical spectrum, assessment, pathogenesis, and treatment of adverse effects of NSAIDs on the small intestine. NSAIDs can cause small intestinal perforation, ulcers, and strictures requiring surgery. NSAIDs produce inflammation of the small intestine in 40 to 70% in long-term users, and the associated complications of blood loss and protein loss are difficult management problems. The pathogenesis of NSAID enteropathy is a multi-stage process involving specific biochemical and subcellular organelle damage followed by inflammatory tissue reaction. Various suggested treatments of NSAID-induced enteropathy (e.g., sulphasalazine, misoprostol, and metronidazole) have yet to undergo rigorous clinical trials. Cyclo-oxygenase-2 inhibitors appear to be safer to the small intestine than traditional NSAIDs. Pre-clinical and clinical data suggests meloxicam, celecoxib, nimesulide and rofecoxib may have less small intestine toxicity than traditional non-selective NSAIDs.
Directivity Factors of the First-Order Steerable Differential Array With Microphone Mismatches: Deterministic and Worst-Case Analysis

It is known that differential microphone arrays are sensitive to microphone mismatches. This paper studies the effects of microphone mismatches on the directivity factor (DF) of the first-order steerable differential array (FOSDA) whose response is constructed by a linear combination of monopole and two orthogonal dipoles via a small four-microphone array. In particular, the DF of the FOSDA is studied from two perspectives, i.e., a deterministic analysis for deterministic microphone gain/phase errors, and a worst-case analysis for uncertain microphone gain/phase errors. Based on the theoretical analysis, several interesting properties are revealed, which are helpful to better understand the robustness characteristics of the FOSDA. Moreover, by worst-case analysis, it provides a useful guidance for robust FOSDA design, i.e., how to determine array size and select microphones with required characteristics such that a desired DF value can be guaranteed. In addition, the effect of sensor self-noise on the DF of the FOSDA is also discussed.
Nasal High-Flow Therapy for Primary Respiratory Support in Preterm Infants.

BACKGROUND Treatment with nasal high-flow therapy has efficacy similar to that of nasal continuous positive airway pressure (CPAP) when used as postextubation support in neonates. The efficacy of high-flow therapy as the primary means of respiratory support for preterm infants with respiratory distress has not been proved. METHODS In this international, multicenter, randomized, noninferiority trial, we assigned 564 preterm infants (gestational age, ≥28 weeks 0 days) with early respiratory distress who had not received surfactant replacement to treatment with either nasal high-flow therapy or nasal CPAP. The primary outcome was treatment failure within 72 hours after randomization. Noninferiority was determined by calculating the absolute difference in the risk of the primary outcome; the chosen margin of noninferiority was 10 percentage points. Infants in whom high-flow therapy failed could receive rescue CPAP; infants in whom CPAP failed were intubated and mechanically ventilated. RESULTS Trial recruitment stopped early at the recommendation of the independent data and safety monitoring committee because of a significant difference in the primary outcome between treatment groups. Treatment failure occurred in 71 of 278 infants (25.5%) in the high-flow group and in 38 of 286 infants (13.3%) in the CPAP group (risk difference, 12.3 percentage points; 95% confidence interval [CI], 5.8 to 18.7; P<0.001). The rate of intubation within 72 hours did not differ significantly between the high-flow and CPAP groups (15.5% and 11.5%, respectively; risk difference, 3.9 percentage points; 95% CI, -1.7 to 9.6; P=0.17), nor did the rate of adverse events. CONCLUSIONS When used as primary support for preterm infants with respiratory distress, high-flow therapy resulted in a significantly higher rate of treatment failure than did CPAP. (Funded by the National Health and Medical Research Council and others; Australian New Zealand Clinical Trials Registry number, ACTRN12613000303741 .).
Immunoglobulin M and immunoglobulin G responses in BALB/c mice to conjugated outer membrane extracts of four Salmonella serotypes

Outer membranes (OMs) of Salmonella enteritidis, S. anatum, S. typhimurium, and S. infantis were extracted and cross-linked with glutaraldehyde to form a large macromolecular antigen. The antigen consisted of OM proteins and lipopolysaccharide and was designated 4-OMP-LPS. Polyacrylamide gel electrophoresis of extracted OMs from each serotype revealed differences in protein profiles. S. enteritidis and S. infantis possessed a greater variety of proteins than did S. anatum and S. typhimurium. Immunizations with 4-OMP-LPS in phosphate-buffered saline (4-OMP-LPS-C) and 4-OMP-LPS emulsified with muramyl dipeptide in the oil phase of a hexadecane-water emulsion (4-OMP-LPS-MDP) revealed that BALB/c mice were capable of eliciting specific primary and secondary immunoglobulin M (IgM) and IgG responses. Both antigen preparations were capable of eliciting IgM and IgG specific for the cell surfaces of each live Salmonella serotype. Also, 4-OMP-LPS-MDP and 4-OMP-LPS-C were capable of evoking a substantial anamnestic response. Adsorption studies revealed that the combined serotypes had the antigenic capacity to adsorb up to 94% of the antibodies, but 4-OMP-LPS-MDP antibodies were more effectively adsorbed than were 4-OMP-LPS-C antibodies. Adsorption of pooled antiserum with heterologous bacteria yielded a variety of adsorption profiles.
Social Connectedness on Facebook - An Explorative Study on Status Message Usage

With over 400 million active users Facebook is undeniably a large social phenomenon and one of the largest social networks on the Internet. Together with Facebook a variety of novel communication styles have developed, dramatically influencing social interaction. The underlying paper reports the results of a survey (N=109) analyzing Facebook’s micro-blogging function available through users’ status updates. Our results suggest that the use of status update messaging generates a feeling of connectedness between users. Furthermore, non-parametric analyses distinguishing between lowand highconnected groups have been performed and experimentally confirmed the existence of distinct user profiles as a function of the variable “feeling connected”. The analyses revealed that the more individuals use their status message function to actively reveal information about themselves, the more connected they feel. Connectedness seems the result of active information sharing modulated by the amount of information shared rather than by the type of information an individual is sharing.
Nanoparticle-Based Bio-Bar Codes for the Ultrasensitive Detection of Proteins

An ultrasensitive method for detecting protein analytes has been developed. The system relies on magnetic microparticle probes with antibodies that specifically bind a target of interest [prostate-specific antigen (PSA) in this case] and nanoparticle probes that are encoded with DNA that is unique to the protein target of interest and antibodies that can sandwich the target captured by the microparticle probes. Magnetic separation of the complexed probes and target followed by dehybridization of the oligonucleotides on the nanoparticle probe surface allows the determination of the presence of the target protein by identifying the oligonucleotide sequence released from the nanoparticle probe. Because the nanoparticle probe carries with it a large number of oligonucleotides per protein binding event, there is substantial amplification and PSA can be detected at 30 attomolar concentration. Alternatively, a polymerase chain reaction on the oligonucleotide bar codes can boost the sensitivity to 3 attomolar. Comparable clinically accepted conventional assays for detecting the same target have sensitivity limits of ∼3 picomdar, six orders of magnitude less sensitive than what is observed with this method.