Miracle-dz/UniFAR-FTUs huggingface dataset:
Selective p38α mitogen-activated protein kinase inhibitor attenuates lung inflammation and fibrosis in IL-13 transgenic mouse model of asthma

p38 Mitogen-activated protein kinase (MAPK) plays a critical role in the activation of inflammatory cells. We investigated the anti-inflammatory effects of a p38α-selective MAPK inhibitor (SD-282) in a mouse transgenic (CC10:IL-13) asthma model. The CC-10-driven over-expression of IL-13 in the mouse lung/airway has been shown to result in a remarkable phenotype recatitulating many features of asthma and characterized by eosinophilic and mononuclear inflammation, with airway epithelial cell hypertrophy, mucus cell metaplasia, the hyperproduction of neutral and acidic mucus, the deposition of Charcot–Leyden-like crystal, and airway sub-epitheilial fibrosis. Here we show how activated p38 MAPK can be observed in the lungs at the onset of asthma ie, around 8 weeks of age in both female and male mice. We also show that administration of a p38α MAPK selective inhibitor, SD-282 at 30 or 90 mg/kg, twice a day for a period of four weeks beginning at the onset of asthma, significantly reduced the inflammation (p < 0.001); hyperplasia of airway epithelium (p < 0.05); goblet cell metaplasia and mucus hypersecretion (p < 0.001) and reduced lung remodeling and fibrosis (p < 0.01), alleviating the severity of lung damage as measured by a composite score (p < 0.05). Furthermore, SD-282 significantly reduced activated p38 MAPK in the lymphocytes and epithelial cells (p < 0.001). Simultaneously, identical studies were conducted with an anti-fibrotic TGFβR1 kinase inhibitor (SD-208) which demonstrated anti-fibrotic but not anti-inflammatory properties. These findings suggest that the p38α-selective MAPK inhibitor may have dual therapeutic potential in attenuating both the inflammatory component and the fibrotic component of asthma and other Th2-polarized inflammatory lung diseases.
Why are we not getting any closer to preventing suicide

In humanistic domains such as ethics, philosophy and anthropology the debate on the legitimacy of preventing suicide seems to have proceeded in parallel with the history of human development (Minois, 1999). Even in the medical world, where suicide has been acknowledged as a primary public health problem within the past century, and where the World Health Organization declared the fight against suicide as a priority for the first time in the year 2000, there is disagreement about the effectiveness of preventive efforts (Wilkinson, 1994). There are many reasons for such scepticism, all of them more or less centred on the extreme complexity of the suicide phenomenon and its relative rarity. A recent World Health Report (World Health Organization, 2001) calculated the number of recorded suicide deaths to be 815 000 worldwide (0.0135% of the global population), a burden slightly lower than the estimate of 1 million published in an earlier technical report dedicated to suicide (World Health Organization, 1999).
Short- and Long-Term Effects of Video Game Violence on Interpersonal Trust

Two studies investigate the psychological processes underlying short- and long-term effects of video game violence on interpersonal trust. Study 1 demonstrates that interacting with physically aggressive virtual agents decreases players' trust in subsequent interactions. This effect was stronger for players who were dispositionally sensitive to victimization. In Study 2, long-term effects of adolescents' frequent exposure to video game violence on interpersonal trust and victim sensitivity were investigated. Cross-lagged path analyses show that the reported frequency of playing violent video games reduced interpersonal trust over a period of 12 months, particularly among victim-sensitive players. These findings are in line with the sensitivity to mean intentions (SeMI) model, and they suggest that interpersonal mistrust is a relevant long-term outcome of frequent exposure to video game violence.
Mutations in WNT10A are present in more than half of isolated hypodontia cases

Background Dental agenesis is the most common, often heritable, developmental anomaly in humans. Mutations in MSX1, PAX9, AXIN2 and the ectodermal dysplasia genes EDA, EDAR and EDARADD have been detected in familial severe tooth agenesis. However, until recently, in the majority of cases (∼90%) the genetic factor could not be identified, implying that other genes must be involved. Recent insights into the role of Wnt10A in tooth development, and the finding of hypodontia in carriers of the autosomal recessive disorder, odontooncychodermal dysplasia, due to mutations in WNT10A (OMIM 257980; OODD), make WNT10A an interesting candidate gene for dental agenesis. Methods In a panel of 34 patients with isolated hypodontia, the candidate gene WNT10A and the genes MSX1, PAX9, IRF6 and AXIN2 have been sequenced. The probands all had isolated agenesis of between six and 28 teeth. Results WNT10A mutations were identified in 56% of the cases with non-syndromic hypodontia. MSX1, PAX9 and AXIN2 mutations were present in 3%, 9% and 3% of the cases, respectively. Conclusion The authors identified WNT10A as a major gene in the aetiology of isolated hypodontia. By including WNT10A in the DNA diagnostics of isolated tooth agenesis, the yield of molecular testing in this condition was significantly increased from 15% to 71%.
Towards End-to-End Speech Recognition with Deep Convolutional Neural Networks

Convolutional Neural Networks (CNNs) are effective models for reducing spectral variations and modeling spectral correlations in acoustic features for automatic speech recognition (ASR). Hybrid speech recognition systems incorporating CNNs with Hidden Markov Models/Gaussian Mixture Models (HMMs/GMMs) have achieved the state-of-the-art in various benchmarks. Meanwhile, Connectionist Temporal Classification (CTC) with Recurrent Neural Networks (RNNs), which is proposed for labeling unsegmented sequences, makes it feasible to train an end-to-end speech recognition system instead of hybrid settings. However, RNNs are computationally expensive and sometimes difficult to train. In this paper, inspired by the advantages of both CNNs and the CTC approach, we propose an end-to-end speech framework for sequence labeling, by combining hierarchical CNNs with CTC directly without recurrent connections. By evaluating the approach on the TIMIT phoneme recognition task, we show that the proposed model is not only computationally efficient, but also competitive with the existing baseline systems. Moreover, we argue that CNNs have the capability to model temporal correlations with appropriate context information.
A Reliable Relay Selection index for Cross layer Approach for Cooperative Cellular Networks

In any cooperative wireless networks the presenceof many mobile stations willing to forward and help indelivering information packets to the destination helps inachieving Cooperative Diversity. The real test is to makesure that the communication is Reliable? Many mobile nodesvary in size and thus having limited energy battery cells andenergy scavenging abilities. This paper is on relay selectionmechanisms for wireless cellular networks. Our mechanismselects the relays which are satisfying the conditions presentat both the physical layer and also at the network layer.For the physical layer we first calculate only those relays inwhich the Signal to Noise (SNR) ratio to the destination isabove the threshold, through which we can further calculatethe Bit Error Rates (BER). For the Network layer we usethe metric of Network Lifetime and for this we calculateResidual Energy(RE) of the relay nodes. Our algorithm hasthe advantage of selecting the best relay at both the physicaland also at the network layer.
Film Criticism in the Twenty-First Century

Beginning with a research question that sought to discover what film criticism actually is, the article uncovers important distinctions between scholarly and practice-orientated conceptions of contemporary film criticism. Through a qualitative mixed-method approach, the article first explores the relevant scholarly literature and a sample of content carriers of film criticism before moving into fieldwork to test findings. Through the process of triangulating these data-sets emerges the motivation to create a schools approach for post-millennia film criticism. The empirical data cover North America and the United Kingdom but the findings may have explanatory potential beyond these territories. Beginning by looking at research on criticism from such prominent scholars as Noël Carrol and Terry Eagleton, a dialectic is uncovered between aesthetic evaluations and socio-political comment. These ideas are then tested in fieldwork by undertaking semi-structured, in-depth qualitative interviews with 30 film critics at two major international film festivals. There is a clear disconnect between scholarly ideas about criticism and two-thirds of the film critics’ conceptions of criticism in their daily routines. From this particular difference of opinion, an Academic School in comparison to Trade and Populist Schools emerges. In turn, this prompts a reappraisal of content carrier data approximated against the fieldwork data and leads to the conceptualising of additional schools: Sophisticated, Fandom and Consumer.
Socio-demographical antecedents of responsible consumerism propensity

The paper analyses consumers’ propensity for socially and environmentally friendly products through socio-demographic indicators. Although the topic has been object of a wide literature, most of the previous studies suffered from methodological or sampling limitations. Hence, the present work addresses such limitations and proposes a study based on a wide heterogeneous sample of 5098 consumers, observed in their real settings. Results show the most responsible consumers are older, well-educated and wealthy, while gender is not a significant antecedent. The in-depth analysis of findings thus confirms the usefulness of socio-demographic variables to understand and determine the profile of responsible consumers. However, the study denies that the propensity to buy responsible products relates to the different sensitiveness of men and women, whereas it underlines that age, education and wealth have a positive relationship. Moreover, the analysis identifies four different profiles of consumer based on the different levels of propensity towards responsible products, which confirms the influence of the socio-demographic variables. This also allows identifying relevant indications on consumers’ decision making, useful to draw indications on possible effective marketing strategies for responsible products.
Genetic susceptibility to herpetic encephalitis of inbred rabbits of B/Jas strain

Inbred rabbits of B/Jas strain were found to be highly susceptible to herpes simplex virus type 1 encephalitis, following i.v. injection of the virus, while Chbb:HM strain rabbits were not susceptible. The susceptibility trait seemed to be inherited recessively, involving multiple genes, because (B/Jas x Chbb:HM)Fl hybrids were as resistant as Chbb:HM rabbits, and because more than 90% of backcrosses of (B/Jas x Chbb: HM)FI to B/Jas were resistant to viral inoculation. The encephalitis in B/Jas rabbits resembled human herpes simplex encephalitis, in that the temporal lobe as well as the brain stem were affected preferentially, leading to the development of various types of seizures, such as circling, loss of balance leading to a fall, and tonic and clonic convulsions. The disease could be diagnosed by magnetic resonance imaging (MRI) analysis before onset of seizures, and diseased rabbits showed a marked lymphopenia at onset of seizures. © 1995 Wiley‐Liss, Inc.
, Hermann Randomized Placebo-Controlled Study of Myoblast Transplantation The Myoblast Autologous Grafting in Ischemic Cardiomyopathy ( MAGIC ) Trial : First

Seymour, Jérôme Larghero, Stephen Lake, Gilles Chatellier, Scott Solomon, Michel Desnos and Reichenspurner, Ludovic Trinquart, Jean-Thomas Vilquin, Jean-Pierre Marolleau, Barbara Philippe Menasché, Ottavio Alfieri, Stefan Janssens, William McKenna, Hermann Randomized Placebo-Controlled Study of Myoblast Transplantation The Myoblast Autologous Grafting in Ischemic Cardiomyopathy (MAGIC) Trial: First Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2008 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation doi: 10.1161/CIRCULATIONAHA.107. 734103 2008;117:1189-1200; originally published online February 19, 2008; Circulation. http://circ.ahajournals. org/content/117/9/1189 World Wide Web at: The online version of this article, along with updated information and services, is located on the
Current Mixed Methods Practices in Qualitative Research: A Content Analysis of Leading Journals

Mixed methods research (MMR) has become increasingly popular in recent years. Yet, methodological challenges of mixing qualitative and quantitative data remain. Understanding how MMR is approached in qualitative research journals provides insights into lingering mixing issues. In this article, we content analyzed five leading qualitative research journals from 2003 to 2014, which represents the reflective period of MMR. Of the 5,254 articles published, 94, or 1.79%, were mixed methods in nature, comprising 44 theoretically oriented articles and 50 empirical articles. In terms of theoretical articles, five content-based themes were identified: (a) MMR advocacy, (b) philosophy issues, (c) procedural suggestions, (d) practical issues and best practices, and (e) future directions. In terms of empirical articles, 36% used exploratory sequential designs, primarily to develop instruments, and 52% explicitly identified as MMR. None of the studies included MMR questions, and development (21%) and complementarity (14%) were the primary rationales for mixing. In virtually all studies (98%), mixing occurred at the data interpretation stage through some comparison of qualitative and quantitative research. Qualitative data were prioritized in 86% of the studies. Based on these findings, it appears that MMR affects qualitative research most directly by influencing study design and study purpose; however, there is a strong tendency to conduct and publish qualitative and quantitative studies separately. Recommendations for publishing future MMR are discussed.
Targeted high-resolution ion mobility separation coupled to ultrahigh-resolution mass spectrometry of endocrine disruptors in complex mixtures.

Traditional separation and detection of targeted compounds from complex mixtures from environmental matrices requires the use of lengthy prefractionation steps and high-resolution mass analyzers due to the large number of chemical components and their large structural diversity (highly isomeric). In the present work, selected accumulation trapped ion mobility spectrometry (SA-TIMS) is coupled to Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) for direct separation and characterization of targeted endocrine-disrupting compounds (EDC) from a complex environmental matrix in a single analysis. In particular, targeted identification based on high-resolution mobility (R ∼ 70-120) and ultrahigh-resolution mass measurements (R > 400 000) of seven commonly targeted EDC and their isobars (e.g., bisphenol A, (Z)- and (E)-diethylstilbestrol, hexestrol, estrone, α-estradiol, and 17-ethynylestradiol) is shown from a complex mixture of water-soluble organic matter (e.g., Suwannee River Fulvic Acid Standard II) complemented with reference standard measurements and theoretical calculations (<3% error).
Increased kallistatin levels in patients with obesity and prediabetes compared to normal glucose tolerance

ABSTRACT Purpose: Kallistatin is a member of serine protease inhibitors (SERPIN) family, which has various functions such as regulation of cardiovascular function and blood vessels development. Its levels are elevated in patients with type 1 and type 2 diabetes with chronic diabetic complications. The aim of the present study was to compare serum kallistatin levels between obese subjects with prediabetes and with normal glucose tolerance. Methods: In this study we included 80 subjects at mean age of 50.4 ± 10.6 years, divided into two age and BMI-matched groups – group 1 with obesity without glycemic disturbances (n = 41) and group 2 with obesity and prediabetes (n = 39). Oral glucose tolerance test with measurement of immunoreactive insulin was performed in all participants and levels of kallistatin were measured using ELISA method. Results: We found significantly higher levels of kallistatin in patients with prediabetes compared to controls (data are presented as median (min; max) because data were not normally distributed) (6.3 (4.4; 9.0) vs. 5.6 (3.1; 8.7) ng/ml; p = 0.022) and in patients with metabolic syndrome compared to those without (6.0 (4.9; 9.0) vs. 5.5 (3.1; 7.7); p = 0.006), but the levels were similar in patients with and without insulin resistance. Conclusions: The levels of kallistatin are higher in individuals with prediabetes, but are similar in subjects with and without insulin resistance, which indicates that the main factor for its increased levels may be hyperglycemia and not insulin sensitivity state.
The Role of Stress and Negative Emotions in an Occupational Crisis

The study examined how negative affects and exposure to various stressors are related to an occupational crisis. Two hundred and seventy-seven employees (53% women) from various occupations filled in the Occupational Crisis Scale, a stressor questionnaire, the Anger Expression Scale (measuring both suppressed and overt anger), Spielberger's Anxiety Inventory (measuring both state and trait anxiety) and Beck's Depression Inventory. The results showed that occupational crisis was a function of work overload, interpersonal problems and frustration at work, organizational changes, a threat of job loss, and/or family worries. In addition, occupational crises were typically experienced by women and were characterized more by trait anxiety, suppressed anger and depressive symptoms than by overtly expressed anger or state anxiety. Of the three female employee groups who were most vulnerable to the crisis, the group which had suffered from interpersonal problems and frustration at work displayed the most indices of the crisis.
Twenty Years of PSPB: Trends in Content, Design, and Analysis

This investigation assessed the nature of research published in Personality and Social Psychology Bulletin (PSPB) during the past 20 years (1976-1996) compared to another major journal in the field, Journal of Personality and Social Psychology (JPSP). Articles in both journals have tended to become longer, to contain more studies, to be authored by more collaborators, and to employ a greater diversity of statistical analyses. Research in both journals has relied heavily on experimental designs using college undergraduates as participants, although the temporal pattern of this reliance is somewhat different in the two journals. Articles in PSPB have consistently emphasized the domain of attitudes and social cognition more than those in JPSP. The implications of these patterns are discussed in terms of their significance for progress in the field and their impact on the career experiences of researchers.
Accumulating meaning, purpose and opportunities to change ‘drip by drip’: the impact of being a listener in prison

Established in 1991, the Listener scheme, regulated by the Samaritans, is currently the best-established peer support scheme in place to help reduce suicide in prisons. Each prison Listener team is comprised of a group of inmate volunteers who provide face-to-face emotional support to their peers. Although the scheme has been in operation for over 20 years, empirical research on the scheme is limited. A deeper understanding of how being a Listener affects prisoners' attitudes, beliefs, emotions and experiences of imprisonment is needed. The present study is a qualitative analysis on the experience of being a Listener and the impact it has on individuals and their prison experience. Interviews were analysed using interpretative phenomenological analysis. The analysis revealed two main superordinate themes: ‘Listening and Personal Transformation’ and ‘Countering Negative Prison Emotions’. These themes are unpacked and the analysis focuses on their implications for desistance and offender reform. Results suggest that prisoners who adopt Listener roles experience profound internal changes, shifts in self-identity and gain meaning and purpose from prison. Implications for how such schemes may be utilised in the future and suggestions for further research are offered.
Psychological Risk Factors for Dissociation and Self-Mutilation in Female Patients with Borderline Personality Disorder *

The purposes of this study were to determine whether or not dissociation in female patients suffering from personality disorder is related to sexual and physical abuse or to abuse parameters and whether or not self-mutilation in the personality disorders is related to psychological risk factors or to dissociation. The sample was divided into 78 borderline and 72 nonborderline personality disorders. Psychological risk factors were measured through histories of childhood sexual abuse, physical abuse and separation or loss as well as scores on the Parental Bonding Index. Dissociation was measured by the Dissociative Experiences Scale. On the diagnostic interview, 48 subjects scored positive for self-mutilation. Dissociative Experiences Scale scores were associated with a borderline diagnosis but not with childhood sexual abuse or physical abuse. The parameters of abuse were not related to dissociation. Subjects who mutilated themselves had higher rates of both childhood sexual abuse and dissociation in univariate analyses. However, in multivariate analyses only diagnosis was significant. None of the other psychological risk factors were significantly linked to self-mutilation. The findings do not support theories that dissociation and self-mutilation in borderline personality disorder are associated with childhood trauma.
Some recent laboratory findings on Mycobacterium leprae. Implications for the therapy, epidemiology and control of leprosy.

From changes in the morphology and viability of Mycobacterium leprae in infected mice, some authors have concluded that the majority of smear-positive human lepromatous patients become non-infectious within 3-4 months of the beginning of regular treatment with sulfones, even at dosages equivalent to only one-hundredth of the conventional daily dose-namely, 1 mg daily. These very low dosages have, however, not been advocated because of the risk that resistant strains of Myco. leprae might develop. The laboratory findings have already been applied to human leprosy by some leprologists; if they were more widely adopted, leprosy programmes could be seriously affected and the consequences could be serious in endemic areas. Contrary to the results of laboratory tests, the shortcomings of clinical sulfone therapy are evident all over the world from the long times required for lepromatous cases to become bacteriologically negative, from the high proportion of relapses and from chemoprophylaxis trials in child contacts. Final proof of the relationship between the morphological index, i.e., the proportion of solidly staining bacilli present, and contagiousness can come only from prolonged and well-planned epidemiological studies. It appears that leprosy may develop in appreciable numbers of child contacts exposed to index cases already bacteriologically negative, with or without prophylactic dapsone treatment.The results of controlled BCG trials now in progress are not consistent although laboratory trials in mice have indicated that BCG vaccination confers a high degree of protection. However, the results that have been obtained in the mouse, an unnatural host, may not be obtainable in man.It is considered premature to apply laboratory findings to human leprosy before clinical and epidemiological studies have been made in man.