Miracle-dz/UniFAR-FTUs huggingface dataset:
Translational Downregulation of HSP90 Expression by Iron Chelators in Neuroblastoma Cells

Iron is an essential cellular nutrient, being a critical cofactor of several proteins involved in cell growth and replication. Compared with normal cells, neoplastic cells have been shown to require a greater amount of iron, thus laying the basis for the promising anticancer activity of iron chelators. In this work, we evaluated the effects of molecules with iron chelation activity on neuroblastoma (NB) cell lines. Of the 17 iron chelators tested, six reduced cell viability of two NB cell lines with an inhibition of growth of 50% below 10 µM; four of the six molecules—ciclopirox olamine (CPX), piroctone, 8-hydroxyquinoline, and deferasirox—were also shown to efficiently chelate intracellular iron within minutes after addition. Effects on cell viability of one of the compounds, CPX, were indeed dependent on chelation of intracellular iron and mediated by both G0/G1 cell cycle block and induction of apoptosis. By combined transcriptome and translatome profiling we identified early translational downregulation of several members of the heat shock protein group as a specific effect of CPX treatment. We functionally confirmed iron-dependent depletion of HSP90 and its client proteins at pharmacologically achievable concentrations of CPX, and we extended this effect to piroctone, 8-hydroxyquinoline, and deferasirox. Given the documented sensitivity of NB cells to HSP90 inhibition, we propose CPX and other iron chelators as investigational antitumor agents in NB therapy.
A systematic review of the relationship between overjet size and traumatic dental injuries.

The aim of this study was to aggregate the risk of traumatic dental injury due to overjet using several published papers and performing a meta-analysis on the results. The 11 articles involved in this investigation were identified by a literature search of Medline (1966-1996) and Exerpta Medica (1985-1996) databases using predetermined keywords, and inclusion and exclusion criteria. In order to assess the quality of each paper, a methodological checklist for observational studies was developed resulting in a score between 0 and 100. The relative risk of overjet, compared with a reference, was expressed as an Odds Ratio (OR). For each study, the OR was computed using the data presented and, subsequently, these ORs were pooled across studies. The effect of confounders (i.e. age, gender), which could bias the relationship between overjet and dental injury was taken into account. Furthermore, the influence of quality of the study on the pooled OR was addressed. The average methodological score was 41. From the results, it can be concluded that children with an overjet larger than 3 mm are approximately twice as much at risk of injury to anterior teeth than children with an overjet smaller than 3 mm. The effect of overjet on the risk of dental injury is less for boys than for girls in the same overjet group. In addition, risk of injury of anterior teeth tends to increase with increasing overjet size. Furthermore, the pooled OR does not seem to be affected by the quality of the studies.
Human semantic MT evaluation with HMEANT for IWSLT 2013

We present the results of large-scale human semantic MT evaluation with HMEANT on the IWSLT 2013 German-English MT and SLT tracks and show that HMEANT evaluates the performance of the MT systems differently compared to BLEU and TER. Together with the references, all the translations are annotated by annotators who are native English speakers in both semantic role labeling stage and role filler alignment stage of HMEANT. We obtain high inter-annotator agreement and low annotation time costs which indicate that it is feasible to run a large-scale human semantic MT evaluation campaign using HMEANT. Our results also show that HMEANT is a robust and reliable semantic MT evaluation metric for running large-scale evaluation campaigns as it is inexpensive and simple while maintaining the semantic representational transparency to provide a perspective which is different from BLEU and TER in order to understand the performance of the state-of-the-art MT systems.
Persistence Service for Non-Persistent P 2 P Systems

Ensuring content persistence with minimal replication overhead is a prerequisite for providing any consistent service over a peer-to-peer (P2P) overlay. This paper introduces S-DATA, a bandwidth efficient protocol for achieving highly available P2P systems with minimal replication overhead. When considering a global P2P system, the cyclic behavior of peers situated at different time zones can be found complementary of one another. In S-DATA, peers with complementary diurnal availability patterns collaborate in small replication groups and host each other’s content in turn to ensure 24/7 availability. In this work we present a mathematical model for measuring time-based availability with (β−1) redundancy as a function of replication group size and peer uptime behavior. We also simulate the S-DATA protocol in the PeerSim simulator and compare its performance against a few other time-based replication protocols.
FVM-based multi-objective topology optimization and Matlab implementation

This paper presents a dapper Matlab implementation of solving multi-objective topology optimization of diffusion problems using the finite volume method. Except for the common objective, some constraints like center of gravity and the manufacturing demands, which are rarely discussed before, are included in this paper. Although specific attention is given to the heat conduction and its applications in this paper, the approach presented can be easily extended to solving other associated diffusion problems. We discussed the basic mathematical model of topology optimization, finite volume analysis, sensitivity derivation, the mathematical programming and some crucial aspects of the Matlab implementation. Some interesting testing examples are provided comparing with those done by the classical FEM-based approach. The complete Matlab code is given in the Appendix and intended for educational purposes.
PENGARUH MODEL PEMBELAJARAN WORD SQUARE TERHADAP HASIL BELAJAR IPA PADA SISWA BERMOTIVASI BELAJAR BERBEDA

Penelitian ini bertujuan untuk meningkatkan hasil belajar IPA di kelas IV SDN Gugus III Arjuna. Rancangan penelitian ini adalah Nonequivalent Control Group Design, dengan menggunakan desin faktorial 2x2. Hasil penelitian menunjukkan: (1) Terdapat perbedaan yang signifikan pada hasil belajar IPA antara kelompok siswa yang mendapatkan perlakuan model pembelajaran Word Square dan kelompok siswa yang tidak mendapatkan perlakuan model pembelajaran Word Square, (2) Tidak terdapat pengaruh interaksi model pembelajaran Word Square dan motivasi belajar terhadap hasil belajar IPA siswa (3) Terdapat perbedaan hasil belajar IPA antara siswa yang mendapatkan perlakuan model pembelajaran Word Square dan kelompok siswa yang tidak mendapatkan perlakuan model pembelajaran Word Square yang memiliki motivasi belajar tinggi, (4) Terdapat perbedaan hasil belajar IPA antara kelompok siswa yang mendapatkan perlakuan model pembelajaran Word Square dan kelompok siswa yang tidak mendapatkan perlakuan model pembelajaran Word Square yang memiliki motivasi belajar rendah. Kata Kunci : Kata kunci: Word Square, motivasi belajar, hasil belajar IPA This studyaims improve science learning outcomes in students of the students fourth grade in SDN III Arjuna. This study design is Noneqiuvalent Control Group Design, by using a factorial 2x2 design. The results showed that: (1) There are differences in science learning outcomes between groups of students who are receive treatmen Word Square learning mode and the group that did not get treatment study Word Square mode, (2) there is no interaction effect of Word Square learning and learning motivation to science learning outcomes, (3) There are differences in science learning outcomes between groups of students who are receive treatment Word Square learning mode and the group that did not get treatment study Word Square mode in students that own hight of motivation, (4) There are differences in science learning outcomes between groups of students who are receive treatment Word Square learning mode and the group that did not get treatment study Word Square mode in students that own low of motivation. keyword : Keywords:Word Sqaure, learning motivation, science learning outcomes
The Internal Representation of Pitch Sequences in Tonal Music

A model for the internal representation of pitch sequences in tonal music is advanced. This model assumes that pitch sequences are retained as hierarchical networks. At each level of the hierarchy, elements are organized as structural units in accordance with laws of figural goodness, such as proximity and good continuation. Further, elements that are present at each hierarchical level are elaborated by further elements so as to form structural units at the next-lower level, until the lowest level is reached. Processing advantages of the system are discussed. It may generally be stated that we tend to encode and retain information in the form of hierarchies when given the opportunity to do so. For example, programs of behavior tend to be retained as hierarchies (Miller, Galanter, & Pribram, 1960) and goals in problem solving as hierarchies of subgoals (Ernst & Newell, 1969). Visual scenes appear to be encoded as hierarchies of subscenes (Hanson & Riseman, 1978; Navon, 1977; Palmer, 1977; Winston, 1973). The phrase structure of a sentence lends itself readily to hierarchical interpretations (Chomsky, 1963; Miller & Chomsky, 1963; Yngve, 1960). When presented with artificial serial patterns that may be hierarchically encoded, we readily form encodings that reflect pattern structure (Bjork, 1968;
Link Adaptation Based on Video Quality Monitoring for H.264/AVC Video Transmission over WLANs

Link adaptation algorithms employed by wireless routers traditionally use retransmission to achieve high error-free data throughput. Such methods do not take into account the delay sensitive nature of video data. In this paper, we investigate the use of reduced-reference video quality monitoring for video oriented link adaptation. Estimation of the quality degradation due to channel errors is performed at the receiver side using the No-Reference video quality Monitoring metric. The estimates are sent to the encoder side where, combined with mean squared error values for the encoded video, they form a reduced reference metric that gives information about the quality of the video at the receiver. Link adaptation is then performed using this reduced reference metric.
Heavy Metal Contamination in the Surface Layer of Bottom Sediments in a Flow-Through Lake: A Case Study of Lake Symsar in Northern Poland

River-lake systems most often behave as hydrographic units, which undergo complex interactions, especially in the contact zone. One such interaction pertains to the role of a river in the dispersal of trace elements carried into and out of a lake. In this study, we aimed to assess the impact of rivers on the accumulation of heavy metals in bottom sediments of natural lakes comprised in postglacial river-lake systems. The results showed that a river flowing through a lake is a key factor responsible for the input of the majority of available fraction of heavy metals (Zn, Mn, Cd and Ni) into the water body and for their accumulation along the flow of river water in the lake. The origin of other accumulated elements were the linear and point sources in catchments. In turn, the Pb content was associated with the location of roads in the direct catchment, while the sediment structure (especially size of fraction and density) could have affected the accumulation of Cr and Zn, which indicated correlations between these metals and fine fraction. Our results suggest that lakes act as filters and contribute to the self-purification of water that flows through them. As a result, the content of most metals in lake sediments showed a decrease by approx. 75% between the upstream (inflow) and downstream (outflow) sections. The increased content of two metals only, such as chromium and cadmium (higher by 2.0 and 2.5 times, respectively, after passing through the lake), was due to the correlation of the metals with fine sand. Both the content and distribution pattern of heavy metals in lake sediments are indicative of the natural response of aquatic ecosystems to environmental stressors, such as pollutant import with river water or climate change. The complex elements creating the water ecosystem of each lake can counteract stress by temporarily removing pollutants such as toxic metals form circulation and depositing them mostly around the delta.
Noncommutativity Parameter and Composite Fermions

We determine some particular values of the noncommutativity parameter \theta and show that the Murthy-Shankar approach is in fact a particular case of a more general one. Indeed, using the fractional quantum Hall effect (FQHE) experimental data, we give a measurement of \theta. This measurement can be obtained by considering some values of the filling factor \nu and other ingredients, magnetic field B and electron density \rho. Moreover, it is found that \theta can be quantized either fractionally or integrally in terms of the magnetic length l_0 and the quantization is exactly what Murthy and Shankar formulated recently for the FQHE. On the other hand, we show that the mapping of the FQHE in terms of the composite fermion basis has a noncommutative geometry nature and therefore there is a more general way than the Murthy-Shankar method to do this mapping.
Technicians in the Workplace: Ethnographic Evidence for Bringing Work into Organizational Studies

The work reported herein was supported under the Educational Research and Development Center program, agreement #R1 17000011-91, CFDA 84.117Q as administered by the Office of Educational Research and Improvement, U.S. Department of Education. The findings and opinions expressed in this report do not reflect the position or policies of the Office of Educational Research and Improvement or the U.S. Department of Education. This paper has profited tremendously from comments offered by Dan Brass, Mark Mizruchi, Bonnie Nelsen, Christine Oliver, Linda Johanson, and the three anonymous scholars who reviewed the manuscript. This paper lays the groundwork for new models of work and relations of production that reflect changes in the division of labor and occupational structure of a postindustrial economy. It demonstrates how new ideal-typical occupations can be constructed, drawing on a set of ethnographies to propose an empirically grounded model of technicians' work. The paper focuses on two questions: What do technicians do and what do they know? The answers constitute a first cut at the ideal type, technician. The paper then turns to evidence of the difficulties that arise when organizations employ technicians but fail to appreciate the nature of their work. It closes by showing how a contextually derived model of technicians' work enables us to evaluate why some recent trends in organizing are congruent with an increasingly technical workforce, why others may be misguided, and why organizations are likely to face challenges that organizational theorists have but vaguely anticipated. The paper shows that the emergence of technicians' work may signify a shift to a more horizontal division of substantive expertise that undermines the logic of vertical organizing on which most organizational theory and practice still rests. '
Interactions between the FTO rs9939609 polymorphism, body mass index, and lifestyle-related factors on metabolic syndrome risk

Whether the FTO polymorphisms interact with environmental factors has not yet been evaluated in associations with metabolic syndrome (MS) risk. The present study investigated the association of the FTO rs9939609 genotypes, body mass index (BMI), and lifestyle-related factors including smoking, alcohol drinking, physical activity, and diet with MS incidence. A population-based prospective cohort study comprised 3,504 male and female Koreans aged 40 to 69 years. At the beginning of the study, all individuals were free of MS and known cardiovascular disease. Incident cases of MS were identified by biennial health examinations during a follow-up period from April 17, 2003 to April 15, 2009. Pooled logistic regression analysis was applied to obtain relative odds (RO) of MS with its 95% confidence interval (CI). After controlling for potential MS risk factors, we observed no association between the rs9939609 genotypes and MS incidence. In analysis stratified by BMI, however, carriers with the FTO risk allele whose BMI is 29 kg/m2 or greater showed an approximately 6-fold higher RO (95% CI: 3.82 to 9.30) compared with non-carriers with BMI less than 25 kg/m2. In particular, the association between the rs9939609 variants and MS risk was significantly modified by high BMI (P-value for interaction < 0.05). Such significant interaction appeared in associations with central obesity and high blood pressure among the MS components. Because carriers of the FTO risk alleles who had BMI of 29 kg/m2 or greater are considered a high risk population, we suggest that they may need intensive weight loss regimens to prevent MS development.
Functional deconvolution in a periodic setting: Uniform case

We extend deconvolution in a periodic setting to deal with functional data. The resulting functional deconvolution model can be viewed as a generalization of a multitude of inverse problems in mathematical physics where one needs to recover initial or boundary conditions on the basis of observations from a noisy solution of a partial differential equation. In the case when it is observed at a finite number of distinct points, the proposed functional deconvolution model can also be viewed as a multichannel deconvolution model. We derive minimax lower bounds for the L 2 -risk in the proposed functional deconvolution model when f(·) is assumed to belong to a Besov ball and the blurring function is assumed to possess some smoothness properties, including both regular-smooth and super-smooth convolutions. Furthermore, we propose an adaptive wavelet estimator of f(·) that is asymptotically optimal (in the minimax sense), or near-optimal within a logarithmic factor, in a wide range of Besov balls. In addition, we consider a discretization of the proposed functional deconvolution model and investigate when the availability of continuous data gives advantages over observations at the asymptotically large number of points. As an illustration, we discuss particular examples for both continuous and discrete settings.
Is there an influence of historical events on contemporary fish species richness in rivers? Comparisons between Western Europe and North America

Freshwater fish species richness on 132 West European and North American rivers is analysed using eleven variables related to contemporary ecology (nine) and history (two). This is done in order to examine the relative and joint effects of both historical and ongoing processes on the contemporary richness of these two regional fish faunas. Relationships are quantified by simple and stepwise multiple regression procedures. Species‐area curves are presented for the fish faunas within both continents. We show that ecological factors statistically explain most of the variation in freshwater fish species richness for both continents. Effects of historical factors are shown to be statistically significant, but add only a little to the variance already explained by ecological factors. Our analyses further indicate that rivers (which flow directly into the ocean) support fewer species of fish than do similarly sized tributaries. The immigration‐extinction hypothesis appears to provide a plausible explanation for this observed pattern. The fact that in our final model, a continental effect is still highly significant, leads us not to exclude the possibility of some other historical influences in generating different overall species richness levels on the two continents.
Incorporation of concentration data below the limit of quantification in population pharmacokinetic analyses

Handling of data below the lower limit of quantification (LLOQ), below the limit of quantification (BLOQ) in population pharmacokinetic (PopPK) analyses is important for reducing bias and imprecision in parameter estimation. We aimed to evaluate whether using the concentration data below the LLOQ has superior performance over several established methods. The performance of this approach (“All data”) was evaluated and compared to other methods: “Discard,” “LLOQ/2,” and “LIKE” (likelihood‐based). An analytical and residual error model was constructed on the basis of in‐house analytical method validations and analyses from literature, with additional included variability to account for model misspecification. Simulation analyses were performed for various levels of BLOQ, several structural PopPK models, and additional influences. Performance was evaluated by relative root mean squared error (RMSE), and run success for the various BLOQ approaches. Performance was also evaluated for a real PopPK data set. For all PopPK models and levels of censoring, RMSE values were lowest using “All data. ” Performance of the “LIKE” method was better than the “LLOQ/2” or “Discard” method. Differences between all methods were small at the lowest level of BLOQ censoring. “LIKE” method resulted in low successful minimization (<50%) and covariance step success (<30%), although estimates were obtained in most runs (~90%). For the real PK data set (7.4% BLOQ), similar parameter estimates were obtained using all methods. Incorporation of BLOQ concentrations showed superior performance in terms of bias and precision over established BLOQ methods, and shown to be feasible in a real PopPK analysis.
Altering Male-Dominant Representations

The generic use of masculine plural forms in grammatical gender languages has been criticized for activating unequal gender representations that are male dominant. The present study examined whether the recently introduced gender-neutral forms of nominalized adjectives and participles in German provide references that induce more balanced representations. We used cross-linguistic differences as a means to illustrate the flexibility of the gender representation system and investigated both native and nonnative (French–German bilinguals) speakers of German. Although a masculine bias persisted when participants read role nouns in the masculine plural form, the study suggests that the usage of nominalized forms can attenuate this male bias, even for nonnative speakers. The results of the study provide further support for the use of gender-neutral language.