Miracle-dz/UniFAR-FTUs huggingface dataset:
Mining User Rationale from Software Reviews

Rationale refers to the reasoning and justification behind human decisions, opinions, and beliefs. In software engineering, rationale management focuses on capturing design and requirements decisions and on organizing and reusing project knowledge. This paper takes a different view on rationale written by users in online reviews. We studied 32,414 reviews for 52 software applications in the Amazon Store. Through a grounded theory approach and peer content analysis, we investigated how users argue and justify their decisions, e.g. about upgrading, installing, or switching software applications. We also studied the occurrence frequency of rationale concepts such as issues encountered or alternatives considered in the reviews and found that assessment criteria like performance, compatibility, and usability represent the most pervasive concept. We then used the truth set of manually labeled review sentences to explore how accurately we can mine rationale concepts from the reviews. Support Vector Classifier, Naive Bayes, and Logistic Regression, trained on the review metadata, syntax tree of the review text, and influential terms, achieved a precision around 80% for predicting sentences with alternatives and decisions, with top recall values of 98%. On the review level, precision was up to 13% higher with recall values reaching 99%. We discuss the findings and the rationale importance for supporting deliberation in user communities and synthesizing the reviews for developers.
Limestone particle size fed to pullets influences subsequent bone integrity of hens

&NA; This study was conducted to evaluate limestone particle size (LPS) in 2 strains of laying hens housed in conventional cages or aviaries on bone integrity. Lohmann Brown and Bovan White pullet chicks were started in equal numbers on the floor or in battery brooders and were intermingled throughout all subsequent housing systems. At 5 wk of age, 432 floor‐raised pullets were moved to 8 aviary cages. At 10 wk, 256 battery‐raised pullets were transferred to 64 conventional layer cages. Pullets were given diets containing fine (LPS‐FINE, 0.431 mm) or a blend of fine and coarse (LPS‐BLEND, 0.879 mm) LPS from 7 to 17 weeks. Data were analyzed as a split plot factorial design with strain as subplot and with 4 replicates for each treatment combination. Body weight, feed intake, egg production, and eggshell breaking strength and percentage were measured. Tibia bone mineral density (BMD) was determined using a dual energy x‐ray absorptiometry. Presence of keel indentations, curvatures, or fractures was recorded. LPS‐BLEND increased BMD (0.215 vs. 0.208, P = 0.03) at 18 weeks. During the pullet phase, the odds of pullets fed LPS‐FINE displaying keel curvatures were 2.8 times the odds of those fed LPS‐BLEND (P = 0.04). At 54 wk, hens fed LPS‐BLEND as pullets had lower odds of keel indentations (P = 0.02). Brown aviary hens fed LPS‐BLEND as pullets had the lowest egg production compared to the rest of the treatment combinations (P = 0.004). Taken together, feeding LPS‐BLEND to pullets improved bone mineralization at the onset of sexual maturity and reduced keel damage during the pullet and layer phases, regardless of strain; however, LPS‐BLEND was associated with lower egg production in Brown hens housed in aviaries compared to all others.
Efficacy of Stiripentol in Dravet Syndrome with or without SCN1A Mutations

Background and Purpose The aim of this study was to determine the effectiveness of stiripentol (STP) add-on therapy to valproate and clobazam in patients with Dravet syndrome (DS) according to the presence of mutations in the sodium channel alpha-1 subunit gene (SCN1A). Methods We performed direct sequencing to analyze SCN1A mutations in 32 patients with clinically confirmed with DS, and classified them into mutation (pathogenic or likely pathogenic) and nonmutation groups based on American College of Medical Genetics and Genomics guidelines. We compared the efficacy of STP in reducing the seizure frequency between the two groups. Results The 32 patients comprised 15 patients in the mutation group (with definite SCN1A mutations) and 17 patients in the nonmutation group with variants of unknown significance or benign variants. The clinical profile did not differ significantly between the mutation and nonmutation groups. The seizure frequency relative to baseline reduced by 72.53±23.00% (mean±SD) in the mutation group versus 50.58±40.14% in the nonmutation group (p=0.004). The efficacy of STP was better in DS patients with missense mutations that in those with truncation mutations, and was not favorable in patients with mutations at linkers between domains (DII–DIII), linkers between segments of domain I (DI S1–S2), or splice sites, although the small number of patients prevented statistical analyses. Conclusions The efficacy of STP was significantly better in DS patients with definite SCN1A mutations than in those without mutations.
Matrix metalloproteinase-8 and tissue inhibitor of matrix metalloproteinase-1 predict incident cardiovascular disease events and all-cause mortality in a population-based cohort

Background Extracellular matrix degrading proteases and their regulators play an important role in atherogenesis and subsequent plaque rupture leading to acute cardiovascular manifestations. Design and methods In this prospective cohort study, we investigated the prognostic value of circulating matrix metalloproteinase-8, tissue inhibitor of matrix metalloproteinase-1 concentrations, the ratio of matrix metalloproteinase-8/ tissue inhibitor of matrix metalloproteinase-1 and, for comparison, myeloperoxidase and C-reactive protein concentrations for incident cardiovascular disease endpoints. The population-based FINRISK97 cohort comprised 7928 persons without cardiovascular disease at baseline. The baseline survey included a clinical examination and blood sampling. During a 13-year follow-up the endpoints were ascertained through national healthcare registers. The associations of measured biomarkers with the endpoints, including cardiovascular disease event, coronary artery disease, acute myocardial infarction, stroke and all-cause death, were analysed using Cox regression models. Discrimination and reclassification models were used to evaluate the clinical implications of the biomarkers. Results Serum tissue inhibitor of matrix metalloproteinase-1 and C-reactive protein concentrations were associated significantly with increased risk for all studied endpoints. Additionally, matrix metalloproteinase-8 concentration was associated with the risk for a coronary artery disease event, myocardial infarction and death, and myeloperoxidase concentration with the risk for cardiovascular disease events, stroke and death. The only significant association for the matrix metalloproteinase-8/ tissue inhibitor of matrix metalloproteinase-1 ratio was observed with the risk for myocardial infarction. Adding tissue inhibitor of matrix metalloproteinase-1 to the established risk profile improved risk discrimination of myocardial infarction (p=0.039) and death (0.001). Both matrix metalloproteinase-8 (5.2%, p < 0.001) and tissue inhibitor of matrix metalloproteinase-1 (12.9%, p < 0.001) provided significant clinical net reclassification improvement for death. Conclusions Serum matrix metalloproteinase-8 and tissue inhibitor of matrix metalloproteinase-1 can be considered as biomarkers of incident cardiovascular disease events and death.
Avoidant Responses to Interpersonal Provocation Are Associated with Increased Amygdala and Decreased Mentalizing Network Activity

Visual Abstract When intentionally pushed or insulted, one can either flee from the provoker or retaliate. The implementation of such fight-or-flight decisions is a central aspect in the genesis and evolution of aggression episodes, yet it is usually investigated only indirectly or in nonsocial situations. In the present fMRI study, we aimed to distinguish brain regions associated with aggressive and avoidant responses to interpersonal provocation in humans. Participants (thirty-six healthy young women) could either avoid or face a highly (HP) and a lowly (LP) provoking opponent in a competitive reaction time task: the fight-or-escape (FOE) paradigm. Subjects avoided the HP more often, but retaliated when facing her. Moreover, they chose to fight the HP more quickly, and showed increased heart rate (HR) right before confronting her. Orbitofrontal cortex (OFC) and sensorimotor cortex were more active when participants decided to fight, whereas the mentalizing network was engaged when deciding to avoid. Importantly, avoiding the HP relative to the LP was associated with both higher activation in the right basolateral amygdala and lower relative activity in several mentalizing regions [e.g., medial and inferior frontal gyrus (IFG), temporal-parietal junction (TPJ)]. These results suggest that avoidant responses to provocation might result from heightened threat anticipation and are associated with reduced perspective taking. Furthermore, our study helps to reconcile conflicting findings on the role of the mentalizing network, the amygdala, and the OFC in aggression.
Correlates of post‐traumatic growth following childhood and adolescent cancer: A systematic review and meta‐analysis

A growing number of children and adolescents are experiencing and surviving cancer. This review aims to identify the demographic, medical, and psychosocial correlates of perceived post‐traumatic growth in individuals of any age who were affected by paediatric cancer. Findings will highlight protective factors that may facilitate post‐traumatic growth, allowing for directed social support, intervention, and follow‐up care.
Family-Based Cluster Randomized Controlled Trial Enhancing Physical Activity and Motor Competence in 4–7-Year-Old Children

Little is known of how to involve families in physical activity (PA) interventions for children. In this cluster randomized controlled trial, we recruited families with four- to seven-year-old children to participate in a year-long study where parents in the intervention group families (n = 46) received tailored counseling to increase children’s PA. Structured PA was not served. Control group families (n = 45) did not receive any counseling. PA in all children (n = 91; mean age 6.16 ± 1.13 years at the baseline) was measured by accelerometers at the baseline and after three, six, nine and 12 months. Motor competence (MC) (n = 89) was measured at the baseline and after six and 12 months by a KTK (KörperkoordinationsTest für Kinder) and throwing and catching a ball (TCB) protocols. The effect of parental counseling on study outcomes was analyzed by a linear mixed-effects model fit by REML and by a Mann-Whitney U test in the case of the TCB. As season was hypothesized to affect counseling effect, an interaction of season on the study outcomes was examined. The results show significant decrease of MVPA in the intervention group when compared to the control group (p < .05). The TCB showed a nearly significant improvement at six months in the intervention group compared to the controls (p = .051), but not at 12 months. The intervention group had a steadier development of the KTK when the interaction of season was taken into account. In conclusion, more knowledge of family constructs associating with the effectiveness of counseling is needed for understanding how to enhance PA in children by parents. However, a hypothesis may be put forward that family-based counseling during an inactive season rather than an active season may provide a more lasting effect on the development of KTK in children. Trial Registration Controlled-Trials.com ISRCTN28668090
CFD Aided Procedure for Optimizing Electrical Mobility Spectrometer

Aerosol measurement is used in a variety of fields such as nanotechnology, materials science, pollution monitoring, air quality measurements, combustion and engine exhaust analysis, inhalation toxicology, and medical studies. One of the most prevalent methods for aerosol measurement is to use electrical mobility. An electrical mobility spectrometer (EMS) is used to measure aerosol particles size distribution ranging from 10 – 1000 nanometers, under the influence of an electric field. The accuracy of this distribution is influenced by flow conditions, the geometry of the EMS, the electric field, and the number of electrode rings. In this work, a multi-channel EMS is studied using computational fluid dynamics to numerically simulate the flow pattern, electric field and particle trajectories in the device. We found that neglecting the effect of the electric field on particles outside the sizing region generates an oversimplified model leading to high particle loss to the flow guide. In order to reduce the number of particle losses and obtaining a more realistic particle distribution we proposed a modification to the electrode electric potential which effectively reduces the particle loss. The applied modification has quintupled the number of particles which are classified by the EMS.
Bacterial Keratitis: Isolated Organisms and Antibiotic Resistance Patterns in San Francisco

Purpose: Understanding the spectrum of pathogens in a given geographic region is important when deciding on empiric antibiotic therapy. In this study, we evaluate the spectrum of bacterial organisms cultured from corneal samples and their antibiotic sensitivities to guide initial treatment of keratitis. Methods: We performed a retrospective case review of cultures from suspected infectious keratitis cases at the Francis I. Proctor Foundation, University of California, San Francisco, from 1996 through 2015. Logistic regression models were used to assess the risk of culturing methicillin-resistant Staphylococcus aureus (MRSA) from ulcers over time and the association between the year cultured and moxifloxacin resistance. Results: A total of 522 of 2203 (23.7%) cultures grew bacterial organisms believed to be the etiology of infection, with available antibiotic sensitivity data. Of these, 338 (65.3%) grew gram-positive organisms with the most common being methicillin-sensitive Staphylococcus aureus (20.1%, N = 105). One hundred eighty (34.7%) grew gram-negative species with Pseudomonas aeruginosa as the most prevalent organism (10.9%, N = 57). There was 1.13 increased odds of culturing MRSA for each 1-year increase in the culture date (P = 0.01) and 1.26 increased odds of culturing an organism resistant to moxifloxacin with each 1-year increase in the culture date after controlling for the infectious organism (P < 0.001). Conclusions: Gram-positive organisms are the most commonly identified etiology of microbial keratitis in this series. Approximately 35% of cultured organisms had variable susceptibility to moxifloxacin, and resistance seems to be increasing over time. The risk of culturing MRSA increased over time.
Functional characterization of a novel 3D model of the epithelial-mesenchymal trophic unit

ABSTRACT Background/Aim: Epithelial-mesenchymal communication plays a key role in tissue homeostasis and abnormal signaling contributes to chronic airways disease such as COPD. Most in vitro models are limited in complexity and poorly represent this epithelial-mesenchymal trophic unit. We postulated that cellular outgrowth from bronchial tissue would enable development of a mucosal structure that recapitulates better in vivo tissue architecture. Materials and Methods: Bronchial tissue was embedded in Matrigel and outgrowth cultures monitored using time-lapse microscopy, electrical resistance, light and electron microscopy. Cultures were challenged repetitively with cigarette smoke extract (CSE). Results: The outgrowths formed as a multicellular sheet with motile cilia becoming evident as the Matrigel was remodeled to provide an air interface; cultures were viable for more than one year. Immunofluorescence and electron microscopy (EM) identified an upper layer of mucociliary epithelium and a lower layer of highly organized extracellular matrix (ECM) interspersed with fibroblastic cells separated by a basement membrane. EM analysis of the mucosal construct after repetitive exposure to CSE revealed epithelial damage, loss of cilia, and ECM remodeling, as occurs in vivo. Conclusions: We have developed a robust bronchial mucosal model. The structural changes observed following CSE exposure suggest the model should have utility for drug discovery and preclinical testing, especially those targeting airway remodeling.
Thermal Insulating Foams Produced From Glass Waste and Banana Leaves

In this work, compositions containing transparent glass bottles and banana leaves (desiccated and crushed), with different mass fractions (30-50%), were prepared for obtaining cellular materials for thermal insulation purposes. The formulated and prepared compositions were uniaxially pressed (10 MPa) and the compact powders fired between 700 and 850°C for 30 min in order to investigate the effect of the banana leaves on the formation of pores and on the thermal and mechanical properties of the processed glass foams. The results indicated that the obtained glass foams with porosities between 58.5 and 87.5%, compressive strength ranging between 1.17 and 3.50 MPa and thermal conductivity ranging between 0.06 and 0.15 W/mK, are potential candidates to work as thermal insulators with appropriate properties for a specific application.
Dry Sliding Wear Behaviour of Sand Cast Cu-11Ni-6Sn Alloy

Wear behaviour of sand cast Cu-11Ni-6Sn alloy was studied using pin-on-disc wear tester with alloy steel disc as counterpart on dry sliding wear conditions. The alloy was prepared from pure elements and melted in an electric furnace under argon atmosphere and cast into sand moulds. The cast rods were homogenized, solution heat treated and aged. Specific wear rate and coefficient of friction were measured in a sliding speed of 191 rpm, 287 rpm and 382 rpm and different normal forces of 10 N, 15 N and 20 N. Hardness of the specimen was found to increase by the aging process and it reached its maximum value, after which it decreased. The specific wear rate was found to increase with the increase in normal load and it decreased with the increase in speed. Co-efficient of friction is independent of hardness of the alloy and dependent on both applied load and speed. The strength of the material is increased by a technique called spinodal decomposition and aging process. In the case of Cu-Ni-Sn system the various alloy composition was not tested for tribological behaviour. Only few alloy compositions are studied. So in this case we have taken Cu-11Ni-6Sn alloy composition. The products made by Cu-Ni-Sn alloy is less costlier compared to Cu-Be products without health hazard and used as high performance connector materials in electronics applications, bearing material in aerospace and mining industries, friction-reducing and anti-wear materials to make high performance bearings for aerospace, roller cone, rock bit and heavy duty mobile industrial equipment.
Are chirps better than clicks and tonebursts for evoking middle latency responses?

BACKGROUND The middle latency response (MLR) is considered a valid clinical tool for assessing the integrity of cortical and subcortical structures. Several investigators have demonstrated that a rising frequency chirp stimulus is capable of eliciting not only larger wave V amplitudes but larger MLR components as well. However, the chirp has never been specifically examined in a hemispheric electrode montage setup that is typical for neurodiagnostic application and site-of-lesion testing. PURPOSE The purpose of this study was to examine the effect of chirp, click, and toneburst stimuli on MLR waveform peak latency and peak-to-peak amplitude in a hemispheric electrode montage setup. RESEARCH DESIGN This study used a repeated-measures design. STUDY SAMPLE A total of 10 young adult participants (3 males, 7 females) with normal hearing were recruited and had negative histories of audiologic, otologic, and neurologic involvement, and no reported language or learning difficulties. DATA COLLECTION AND ANALYSIS MLR latencies (Na, Pa, Nb, and Pb) and peak-to-peak amplitudes (Na-Pa, Pa-Nb, and Nb-Pb) were measured for all conditions and were statistically evaluated for left hemisphere-right ear (C3-A2) and right hemisphere-left ear (C4-A1) recordings. RESULTS Statistical analyses revealed no significant difference between C3-A2 and C4-A1 peak-to-peak amplitudes; therefore, data were collapsed. Stimulus comparisons revealed that Na evoked by tonebursts were statistically prolonged compared with both chirp and click, and that both Na-Pa and Pa-Nb peak-to-peak amplitudes were statistically larger for chirps compared with both clicks and tonebursts, and for clicks compared with tonebursts. CONCLUSIONS The results of this study support the hypothesis that a chirp would offer a clinical advantage to the click and toneburst in overall peak-to-peak amplitude. As expected, normal-hearing participants did not exhibit hemispheric differences when comparing C3-A2 and C4-A1 peak-to-peak amplitudes demonstrating symmetric auditory brain function. However, chirp-evoked MLRs will require further study to determine its usefulness in clinical practice.
Body physique and proportionality of Brazilian female artistic gymnasts

ABSTRACT This study aimed to identify physique characteristics (anthropometry, somatotype, body proportionality) of Brazilian female artistic gymnasts, and to compare them across competitive levels (sub-elite versus non-elite) within competitive age-categories. Two hundred forty-nine female gymnasts (68 sub-elite; 181 non-elite) from 26 Brazilian gymnastics clubs, aged 9–20 years and split into four age-categories, were sampled. Gymnasts were assessed for 16 anthropometric traits (height, weight, lengths, widths, girths, and skinfolds); somatotype was determined according to Heath-Carter method, body fat was estimated by bioimpedance, and proportionality was computed based on the z-phantom strategy. Non-elite and sub-elite gymnasts had similar values in anthropometric characteristics, however non-elite had higher fat folds in all age-categories (P < 0.01). In general, mesomorphy was the salient somatotype component in all age-categories, and an increase in endomorphy, followed by a decrease in ectomorphy across age was observed. Regarding proportionality, profile similarity was found between sub-elite and non-elite within age-categories. In conclusion results suggest the presence of a typical gymnast’s physical prototype across age and competitive level, which can be useful to coaches during their selection processes in clubs and regional/national teams.