Miracle-dz/UniFAR-FTUs huggingface dataset:
Life-Threatening Complications of HIV Infection

Few modern diseases have experienced as rapid and dramatic change in prognosis and treatment as HIV infection. The introduction of active antiretroviral therapy (ART) and effective prophylaxis of opportunistic infections ushered in a new era in the treatment of HIV infection and changed dramatically the natural history of this disease. The rates of admission to the intensive care unit (ICU) and intensive care mortality in patients with HIV infection have shifted repeatedly during the AIDS epidemic, influenced by attitudes of patients and providers toward utility of care. In the ART era, patients with HIV infection admitted to the ICU fall into 3 general categories: those with AIDS-related opportunistic infections, those who are experiencing complications related to ART, and those with medical problems unrelated to HIV infection. In this article, the authors provide a review of the most common life-threatening complications in patients with HIV infection.
Spatially localized binary-fluid convection

Multiple states of spatially localized steady convection are found in numerical simulations of water–ethanol mixtures in two dimensions. Realistic boundary conditions at the top and bottom are used, with periodic boundary conditions in the horizontal. The states form by a mechanism similar to the pinning region around a Maxwell point in variational systems, but are located in a parameter regime in which the conduction state is overstable. Despite this the localized states can be stable. The properties of the localized states are described in detail, and the mechanism of their destruction with increasing or decreasing Rayleigh number is elucidated. When the Rayleigh number becomes too large the fronts bounding the state at either end unpin and move apart, allowing steady convection to invade the domain. In contrast, when the Rayleigh number is too small the fronts move inwards, and eliminate the localized state which decays into dispersive chaos. Out of this state spatially localized states re-emerge at irregular times before decaying again. Thus an interval of Rayleigh numbers exists that is characterized by relaxation oscillations between localized convection and dispersive chaos.
Sensitivity of Medicare Claims Data for Measuring Use of Standard Multiagent Chemotherapy Regimens

Purpose:We sought to determine the accuracy with which Medicare billing data documents elderly Medicare cancer patients’ receipt of common multiagent chemotherapy regimens. Methods:We merged gold-standard clinical trial data from 406 elderly cancer patients known to be treated on 1 of 6 Cancer and Leukemia Group B (CALGB) breast, colorectal, and lung cancer trials (trial numbers; 9344, 9730, 9235,9732, 80203, 89803) with their Medicare claims data from Centers for Medicare and Medicaid Services (CMS). Comparing CMS chemotherapy codes to gold-standard CALGB treatment data, we estimated Medicare data’s sensitivity at measuring the correct drugs and schedule for each of the multiagent chemotherapy regimens. Results:Overall 92% (375/406) of CALGB patients had contemporaneous CMS claims indicating receipt of chemotherapy. The overall sensitivity of CMS ambulatory claims for documenting treatment with the correct drugs and on the correct schedule (ie, all drugs had to be billed on the same day) for the 5 common multiagent chemotherapy regimens was 78% (275/354) for those potentially treated in the ambulatory setting. The sensitivity was similar for all treatment regimens: carboplatin and paclitaxel 83%, 5-fluorouracil and leucovorin 80%, fluorouracil, leucovorin, and irinotecan (FOLFIRI) 76%, doxorubicin and cyclophosphamide 75%, and cisplatin and etoposide 75%. Conclusions:We correctly identified at least 3-quarters of elderly Medicare cancer patients treated on a clinical trial with standard first-line multiagent chemotherapy regimens in the ambulatory setting by applying coding algorithms to their CMS claims. The algorithms may be useful in identifying cohorts of elderly Medicare patients for observational studies of the comparative effectiveness of standard multiagent chemotherapy regimens.
Cell Surface Display of Organophosphorus Hydrolase Using Ice Nucleation Protein

A new anchor system based on the ice nucleation protein (InaV) from Pseudomonas syringae INA5 was developed for cell surface display of functional organophosphorus hydrolase (OPH). The activity and stability of cells expressing the truncated InaV (INPNC)‐OPH fusions were compared to cells with surface‐expressed OPH using two other fusion anchors based on Lpp‐OmpA and the truncated InaK protein. Whole cell activity was as much as 5‐fold higher using the InaV anchor. Majority of the OPH activity was located on the cell surface as determined by protease accessibility and cell fractionation experiments. The surface localization of OPH was further verified by immunofluorescence microscopy. Constitutive expression of OPH on the surface using the InaV anchor resulted in no cell lysis or growth inhibition, in contrast to the Lpp‐OmpA anchor. Suspended cultures also exhibited good stability, retaining almost 100% activity over a period of 3 weeks. Therefore, the InaV anchor system offers an attractive alternative to the currently available surface anchors, providing high‐level expression and superior stability.
Milky Way type galaxies in a ΛCDM cosmology

We analyse a sample of 52000 Milky Way (MW) type galaxies drawn from the publicly available galaxy catalogue of the Millennium Simulation with the aim of studying statistically the differences and similarities of their properties in comparison to our Galaxy. Model galaxies are chosen to lie in haloes with maximum circular velocities in the range 200-250 km s -1 and to have bulge-to-disc ratios similar to that of the MW. We find that model MW galaxies formed 'quietly' through the accretion of cold gas and small satellite systems. Only ≈12 per cent of our model galaxies experienced a major merger during their lifetime. Most of the stars formed 'in situ', with only about 15 per cent of the final mass gathered through accretion. Supernovae (SNe) and active galactic nuclei (AGN) feedback play an important role in the evolution of these systems. At high redshifts, when the potential wells of the MW progenitors are shallower, winds driven by SNe explosions blow out a large fraction of the gas and metals. As the systems grow in mass, SNe feedback effects decrease and AGN feedback takes over, playing a more important role in the regulation of the star formation activity at lower redshifts. Although model MW galaxies have been selected to lie in a narrow range of maximum circular velocities, they nevertheless exhibit a significant dispersion in the final stellar masses and metallicities. Our analysis suggests that this dispersion results from the different accretion histories of the parent dark matter haloes. Statistically, we also find evidences to support the MW as a typical Sb/Sc galaxy in the same mass range, providing a suitable benchmark to constrain numerical models of galaxy formation.
Black–White and Country of Birth Disparities in Retention in HIV Care and Viral Suppression among Latinos with HIV in Florida, 2015

The study’s purpose was to identify HIV, Black–White race, and birth country disparities in retention in HIV care and HIV viral load (VL) suppression among Latinos, in 2015. Florida’s surveillance data for Latinos diagnosed with HIV (2000–2014) were merged with American Community Survey data. Multi-level (random effects) models were used to estimate adjusted odds ratios (aOR) for non-retention in care and non-viral load suppression. Blacks and Whites experienced similar odds of non–retention in care. Racial differences in VL suppression disappeared after controlling for neighborhood factors. Compared to U.S.–born Latinos, those born in Mexico (retention aOR 2.00, 95% CI 1.70–2.36; VL 1.85, 95% CI 1.57–2.17) and Central America (retention aOR 1.33, 95% CI 1.16–1.53; VL 1.28, 95% CI 1.12–2.47) were at an increased risk after controlling for individual and neighborhood factors. Among Central Americans, those born in Guatemala (retention aOR 2.39, 95% CI 1.80–3.18; VL 2.20, 95% CI 1.66–2.92) and Honduras (retention aOR 1.39, 95% CI 1.13–1.72; VL 1.42, 95% CI 1.16–1.74) experienced the largest disparities, when compared to U.S.-born Latinos. Disparities in care and treatment exist within the Latino population. Cultural and other factors, unique to Latino Black-White racial and birth country subgroups, should be further studied and considered for intervention.
SEXUAL CONFLICT AND INTERACTING PHENOTYPES: A QUANTITATIVE GENETIC ANALYSIS OF FECUNDITY AND COPULA DURATION IN DROSOPHILA MELANOGASTER

Many reproductive traits that have evolved under sexual conflict may be influenced by both sexes. Investigation of the genetic architecture of such traits can yield important insight into their evolution, but this entails that the heritable component of variation is estimated for males and females—as an interacting phenotype. We address the lack of research in this area through an investigation of egg production and copula duration in the fruit fly, Drosophila melanogaster. Despite egg production rate being determined by both sexes, which may cause sexual conflict, an assessment of this trait as an interacting phenotype is lacking. It is currently unclear whether copula duration is determined by males and/or females. We found significant female, but not male, genetic variance for egg production rate that may indicate reduced potential for ongoing sexually antagonistic coevolution. In contrast, copula duration was determined by significant genetic variance in both sexes. We also identified genetic variation in egg retention among virgin females. Although previously identified in wild populations, it is unclear why this should be present in a laboratory stock. This study provides a novel insight into the shared genetic architecture of reproductive traits that are the subject of sexual conflict.
Predicting bullying and victimization among early adolescents: Associations with disruptive behavior disorders

Bullying is a common problem faced by children and adolescents in schools. One hypothesis that needs to be examined regarding the causation of this problem is whether being a bully or a victim may stem from disparate underlying patterns of psychopathology. Results are particularly scarce regarding the association between bully-victim problems and disruptive behavior disorders. The present study sought to investigate the association between DSM-IV symptoms of Oppositional Defiant Disorder (ODD), Conduct Disorder (CD), and bully-victim problems in a sample of 202 adolescents, aged 12-15, attending two junior high schools in Cyprus, to determine whether these symptoms differentiate between bullies and victims and provide a new approach to the understanding of bully-victim problems. Students completed measures of bullying, victimization, disruptive behavior disorder symptoms, and self-esteem, along with demographic questions. On the basis of their responses, teenagers were classified as bullies, victims, or both bullies and victims. Those who were bully/victims reported greater CD symptomatology. CD and low self-esteem were predictive of bullying, whereas ODD and low self-esteem were predictive of victimization.
Cytochrome-C Oxidase Deficiency

The severity of cytochrome c oxidase deficiency varies widely among affected individuals, even among those in the same family. People who are mildly affected tend to have muscle weakness (myopathy) and poor muscle tone (hypotonia) with no other related health problems. More severely affected people have problems in multiple body systems, often including severe brain dysfunction (encephalomyopathy). Approximately one-quarter of individuals with cytochrome c oxidase deficiency have a type of heart disease that enlarges and weakens the heart muscle (hypertrophic cardiomyopathy). Another possible feature of this condition is an enlarged liver (hepatomegaly), which may lead to liver failure. Most individuals with cytochrome c oxidase deficiency have a buildup of a chemical called lactic acid in the body (lactic acidosis), which can cause nausea and an irregular heart rate, and can be life-threatening.
Exploiting States’ Mistakes to Identify the Causal Impact of Higher Education on Growth

Should countries or regions invest more in higher education in order to grow faster? Recent policy reports on growth and productivity in Europe versus the United States1 , for example argue that a major cause for the relatively slow growth in Europe is its underinvestment in higher education. Pre-enlargement, the European Union invested only 1.1 percent of its total annual gross domestic product in higher education compared with 3 percent in the United States. A key reason why investment in tertiary education may enhance growth is that such investments are likely to stimulate complementary investments in research and development, thereby fostering technological innovation. This explanation is consistent with panel data on American executivestertiary education and their enterprisesinvestment in research and development. Scherer and Hue (1992), using data on 221 enterprises from 1970 to 1985, nd a positive and signi cant correlation between executiveslevel of technical education and spending on research and development. Of course, this correlation is no guarantee , of causality but does suggest a possible complementarity between investments in higher education and investments in research and development. This complementarity is stressed by Romer (2000),2 who argues that research and development subsidies that are unaccompanied by an increase in the supply of researchers or technicians will result in an increase in the relative price of highly educated labor but little increase in aggregate research and development and, therefore, little or no change in productivity growth.3
Learning discriminative space-time actions from weakly labelled videos

Current state-of-the-art action classification methods extract feature representations from the entire video clip in which the action unfolds, however this representation may include irrelevant scene context and movements which are shared amongst multiple action classes. For example, a waving action may be performed whilst walking, however if the walking movement and scene context appear in other action classes, then they should not be included in a waving movement classifier. In this work, we propose an action classification framework in which more discriminative action subvolumes are learned in a weakly supervised setting, owing to the difficulty of manually labelling massive video datasets. The learned models are used to simultaneously classify video clips and to localise actions to a given space-time subvolume. Each subvolume is cast as a bag-offeatures (BoF) instance in a multiple-instance-learning framework, which in turn is used to learn its class membership. We demonstrate quantitatively that even with single fixedsized subvolumes, the classification performance of our proposed algorithm is superior to the state-of-the-art BoF baseline on the majority of performance measures, and shows promise for space-time action localisation on the most challenging video datasets.
A cadherin-like protein in eggs and cleaving embryos of Xenopus laevis is expressed in oocytes in response to progesterone

A new cadherin-like protein (CLP) was identified in oocytes, eggs, and cleavage stage embryos of Xenopus laevis. As a probe for detecting new cadherin proteins, an antiserum was raised to a 17 amino acid peptide derived from a highly conserved region in the cytoplasmic domain of all cadherins which have been sequenced to date. This antipeptide antibody recognized Xenopus E-cadherin and a polypeptide in Xenopus brain extracts similar to N-cadherin, which were independently identified by specific mAbs. In extracts of eggs and midblastula stage embryos the antipeptide antibody recognized specifically a 120-kD glycoprotein that migrated faster on SDS gels than the 140-kD E- and N-cadherin polypeptides. This 120-kD polypeptide was not recognized by the mAbs specific to E- and N-cadherin. In fact, E- and N-cadherin were not detectable in eggs or midblastula stage embryos. The possible relationship of CLP to P-cadherin, which has been identified in mouse tissues, has not yet been determined. CLP was synthesized by large, late stage oocytes. When oocytes were induced to mature in vitro with progesterone it accumulated to the same level found in normally laid eggs. It did not accumulate further to any significant extent during the early cleavage stages. CLP was detected on the surface of stage 8 blastomeres by cell surface biotinylation, but only after the tight junctions of the blastula epithelium were opened by removal of Ca2+. We conclude that CLP is a maternally encoded protein that is the major, if not only, cadherin-related protein present in the earliest stages of Xenopus development, and we propose that it may play a role in the Ca2(+)-dependent adhesion and junction formation between cleavage stage blastomeres.
The Role of Awareness in Semantic and Syntactic Processing: An ERP Attentional Blink Study

An important question in the study of language is to what degree semantic and syntactic processes are automatic or controlled. This study employed an attentional blink (AB) paradigm to manipulate awareness in the processing of target words in order to assess automaticity in semantic and syntactic processing. In the semantic block, targets occurring both within and outside the AB period elicited an N400. However, N400 amplitude was significantly reduced during the AB period, and missed targets did not elicit an N400. In the syntactic block, ERPs to targets occurring outside the AB period revealed a late negative syntactic incongruency effect, whereas ERPs to targets occurring within the AB period showed no effect of incongruency. The semantic results support the argument that the N400 primarily indexes a controlled, postlexical process. Syntactic findings suggest that the ERP response to some syntactic violations depends on awareness and availability of attentional resources.
Toward a Reevaluation of Reader Response and School Literature.

This paper reconsiders the nature of literature as a school subject. Musing on three anomalies that occur when language arts teachers consider their professions about school literature and what occurs in literature classrooms: (1) the anomaly of the text and the textbook; (2) the anomaly of the idolatry of naive readers whose heads have been "stuffed"; and (3) the anomalous role of the writer in literature and writing programs, the paper contends that these anomalies only serve to trivialize literature in schools. Exploring the nature of the "rules of the game" of school literature in the United States, the paper argues that school literature programs must treat literary texts as works of art and that literature programs need to be integrated into a broader context of the language arts. The paper questions the role of literature and literature education in American society and asserts that such a resource should serve as the cornerstone of education in a democratic society. The paper concludes that students must be helped to connect the way they read to the way they write, to develop a sense of pleasure in the medium of language and in the exploration of the culture of the writer and of the community of readers in the classroom. (Contains 19 references.) (SAM) *********************************************************************** Reproductions supplied by EDRS are the best that can be made from the original document. *********************************************************************** Towards a Revaluation of Reader Response and School Literature
Isolation of an Active Catalytic Core ofStreptococcus downei MFe28 GTF-I Glucosyltransferase

ABSTRACT Truncated variants of GTF-I from Streptococcus downeiMFe28 were purified by means of a histidine tag. Sequential deletions showed that the C-terminal domain was not directly involved in the catalytic process but was required for primer activation. A fully active catalytic core of only 100 kDa was isolated.
Association of severe asthma attacks with weather, pollen, and air pollutants.

BACKGROUND: The association between exacerbations of asthma and weather or air pollution is not well understood. The relationships between visits to the emergency room for asthma attacks and the meteorological, aerobiological, and chemical characteristics of the outdoor air have been evaluated. METHODS: The number of daily attendances for asthma attacks at the emergency room of Oulu University Central Hospital was recorded over one year together with daily meteorological readings (temperature, humidity, barometric pressure, rainfall), levels of air pollutants (nitrogen dioxide (NO2), sulphur dioxide (SO2), hydrogen sulphide (H2S), total suspended particles (TSP)), and pollen counts (birch, alder, pine, willow, total pollen). The relationship between the number of attendances and the measured variables was then analysed by multiple regression and stepwise discriminant analysis. RESULTS: The total number of attendances during the year was 232, with lower figures in summer and higher in winter. No association was found between visits for asthma attacks and airborne pollen levels or meteorological factors except for temperature, which had a low inverse correlation with attendance. The most significant correlations were found between asthma visits and the levels of NO2; those for SO2, TSP, and H2S were also significant. Intercorrelations between SO2 and temperature or NO2 and between temperature and TSP or NO2 were also found, but only NO2 correlated significantly with attendances after standardisation for temperature. CONCLUSIONS: Increased levels of pollutants, especially NO2, were associated with attacks of asthma, but the explanation for this is unclear. Air pollen levels were not associated with asthma attacks and only temperature among the meteorological factors had a small association with asthma.
What Should Be Taught in Secondary Schools’ Nutrition and Food Systems Education? Views from Prominent Food-Related Professionals in Australia

Education can help young people to attain the knowledge and the skills that they need to make proper food choices and develop lifelong healthy eating patterns. This study explored the perspectives of prominent food-related professionals in Australia regarding essential nutrition and food systems (N&FS) education programs for adolescents during formal education. Semi-structured interviews were conducted with 21 prominent food-related professionals in Australia. Interview transcripts were analysed thematically. Four essential areas for N&FS education programs were identified. (1) Key nutrition messages to a healthy lifestyle; (2) Skill development programs to enhance health and wellbeing; (3) Ethical food-related lessons to support environmental sustainability, farm animal welfare, local producers, and food security; and, (4) Introductory lessons about foods from farm to plate to facilitate more informed food choices. Findings of this study may provide new insights for curriculum developers in Australia for further assessment of the current gaps in N&FS components of secondary school curriculum. Integration of these four areas into secondary school curricula has the potential to enhance adolescents’ knowledge of important scientific and ethical issues in a range of N&FS fields, and enable them to develop fundamental food-related life skills that are supportive of health and wellbeing.