Miracle-dz/UniFAR-FTUs huggingface dataset:
Antibodies to major histocompatibility complex class II antigens directly prime neutrophils and cause acute lung injury in a two‐event in vivo rat model

Transfusion‐related acute lung injury (TRALI) is a significant cause of mortality, especially after transfusions containing antibodies to major histocompatibility complex (MHC) class II antigens. We hypothesize that a first event induces both 1) polymorphonuclear neutrophils (PMNs) to express MHC class II antigens, and 2) activation of the pulmonary endothelium, leading to PMN sequestration, so that the infusion of specific MHC class II antibodies to these antigens causes PMN‐mediated acute lung injury (ALI).
Correction of Current Transformer Transient Performance

If a current transformer (CT) saturates while transforming the heavy primary current, in each period, there are sections when the magnetic core is unsaturated and transformation is correct, and when it is saturated, it causes enormous errors. The key to correct the errors is to detect instants of saturation and moments when the saturation ends. This paper presents simple and efficient methods of doing that. In addition, it shows the way how to predict up to three samples after saturation with the acceptable degree of accuracy, thus artificially expanding the unsaturated section. It may substantially facilitate operation of protective devices. The ultimate solution of the problem is to estimate the values of the fundamental frequency component amplitude and the decaying DC component in each period. This paper presents the method of doing that on the ground of four consecutive samples taken during the unsaturated section. If the primary current consists of the fundamental and DC exponential components only, the accuracy of the method is excellent. Neglecting contamination of the current signal with harmonics and noise, it is possible to reconstruct the CT primary current based on the measured values of fundamental and DC components.
Reward Augmented Maximum Likelihood for Neural Structured Prediction

A key problem in structured output prediction is direct optimization of the task reward function that matters for test evaluation. This paper presents a simple and computationally efficient approach to incorporate task reward into a maximum likelihood framework. By establishing a link between the log-likelihood and expected reward objectives, we show that an optimal regularized expected reward is achieved when the conditional distribution of the outputs given the inputs is proportional to their exponentiated scaled rewards. Accordingly, we present a framework to smooth the predictive probability of the outputs using their corresponding rewards. We optimize the conditional log-probability of augmented outputs that are sampled proportionally to their exponentiated scaled rewards. Experiments on neural sequence to sequence models for speech recognition and machine translation show notable improvements over a maximum likelihood baseline by using reward augmented maximum likelihood (RAML), where the rewards are defined as the negative edit distance between the outputs and the ground truth labels.
Pedicle Screw Insertion Accuracy Using O-Arm, Robotic Guidance, or Freehand Technique: A Comparative Study

Study Design. A retrospective radiological study. Objective. The aim of this study was to evaluate the accuracy of pedicle screw insertion using O-Arm navigation, robotic assistance, or a freehand fluoroscopic technique. Summary of Background Data. Pedicle screw insertion using either “O-Arm” navigation or robotic devices is gaining popularity. Although several studies are available evaluating each of those techniques separately, no direct comparison has been attempted. Methods. Eighty-four patients undergoing implantation of 569 lumbar and thoracic screws were divided into three groups. Eleven patients (64 screws) had screws inserted using robotic assistance, 25 patients (191 screws) using the O-arm, while 48 patients (314 screws) had screws inserted using lateral fluoroscopy in a freehand technique. A single experienced spine surgeon assisted by a spinal fellow performed all procedures. Screw placement accuracy was assessed by two independent observers on postoperative computed tomography (CTs) according to the A to D Rampersaud criteria. Results. No statistically significant difference was noted between the three groups. About 70.4% of screws in the freehand group, 69.6% in the O arm group, and 78.8% in the robotic group were placed completely within the pedicle margins (grade A) (P > 0.05). About 6.4% of screws were considered misplaced (grades C&D) in the freehand group, 4.2% in the O-arm group, and 4.7% in the robotic group (P > 0.05). The spinal fellow inserted screws with the same accuracy as the senior surgeon (P > 0.05). Conclusion. The advent of new technologies does not appear to alter accuracy of screw placement in our setting. Under supervision, spinal fellows might perform equally well to experienced surgeons using new tools. The lack of difference in accuracy does not imply that the above-mentioned techniques have no added advantages. Other issues, such as surgeon/patient radiation, fiddle factor, teaching suitability, etc., outside the scope of our present study, need further assessment. Level of Evidence: 3
Metastatic Extramammary Paget’s Disease: Pathogenesis and Novel Therapeutic Approach

Extramammary Paget’s disease (EMPD) is a rare, slow-growing, cutaneous adenocarcinoma that usually originates in the anogenital area and axillae outside the mammary glands. EMPD mostly progresses slowly and is often diagnosed as carcinoma in situ; however, upon becoming invasive, it promptly and frequently metastasizes to regional lymph nodes, leading to subsequent distant metastasis. To date, several chemotherapy regimens have been used to treat metastatic EMPD; however, they present limited effect and patients with distant metastasis exhibit a poor prognosis. Recently, basic and translational investigative research has elucidated factors and molecular mechanisms underlying the promotion of metastasis, which can lead to targeted therapy-based emerging treatment strategies. Here, we aim to discuss current therapies and their limitations; advancements in illustrating mechanisms promoting invasion, migration, and proliferation of EMPD tumor cells; and future therapeutic approaches for metastatic EMPD that may enhance clinical outcomes.
Personalized machine learning for robot perception of affect and engagement in autism therapy

Personalized machine learning enables robot perception of children’s affective states and engagement during robot-assisted autism therapy. Robots have the potential to facilitate future therapies for children on the autism spectrum. However, existing robots are limited in their ability to automatically perceive and respond to human affect, which is necessary for establishing and maintaining engaging interactions. Their inference challenge is made even harder by the fact that many individuals with autism have atypical and unusually diverse styles of expressing their affective-cognitive states. To tackle the heterogeneity in children with autism, we used the latest advances in deep learning to formulate a personalized machine learning (ML) framework for automatic perception of the children’s affective states and engagement during robot-assisted autism therapy. Instead of using the traditional one-size-fits-all ML approach, we personalized our framework to each child using their contextual information (demographics and behavioral assessment scores) and individual characteristics. We evaluated this framework on a multimodal (audio, video, and autonomic physiology) data set of 35 children (ages 3 to 13) with autism, from two cultures (Asia and Europe), and achieved an average agreement (intraclass correlation) of ~60% with human experts in the estimation of affect and engagement, also outperforming nonpersonalized ML solutions. These results demonstrate the feasibility of robot perception of affect and engagement in children with autism and have implications for the design of future autism therapies.
Nutrition And Athletic Performance

It is the position of the Academy of Nutrition and Dietetics, Dietitians of Canada, and the American College of Sports Medicine that the performance of, and recovery from, sporting activities are enhanced by well-chosen nutrition strategies. These organizations provide guidelines for the appropriate type, amount, and timing of intake of food, fluids, and supplements to promote optimal health and performance across different scenarios of training and competitive sport. This position paper was prepared for members of the Academy of Nutrition and Dietetics, Dietitians of Canada (DC), and American College of Sports Medicine (ACSM), other professional associations, government agencies, industry, and the public. It outlines the Academy_s, DC_s and ACSM_s stance on nutrition factors that have been determined to influence athletic performance and emerging trends in the field of sports nutrition. Athletes should be referred to a registered dietitian/ nutritionist for a personalized nutrition plan. In the United States and in Canada, the Certified Specialist in Sports Dietetics (CSSD) is a registered dietitian/nutritionist and a credentialed sports nutrition expert.
Barriers to Care and Health Care Utilization Among the Publicly Insured

Background: Although the Affordable Care Act has been successful in expanding Medicaid to >17 million people, insurance alone may not translate into access to health care. Even among the insured, substantial barriers to accessing services inhibit health care utilization. Objectives: We examined the effect of selected barriers to health care access and the magnitude of those barriers on health care utilization. Research Design: Data come from a 2008 survey of adult enrollees in Minnesota’s public health care programs. We used multivariate logistic regression to estimate the effects of perceived patient, provider, and system-level barriers on past year delayed, foregone, and lack of preventive care. Subjects: A total of 2194 adults enrolled in Minnesota Health Care Programs who were mostly female (66%), high school graduates (76%), unemployed (62%), and living in metro areas (67%) were included in the analysis. Results: Reporting problems across all barriers increased the odds of delayed care from 2 times for provider-related barriers (OR=2.0; 95% CI, 1.2–3.3) to >6 times for access barriers (OR=6.2; 95% CI, 3.8–10.2) and foregone care from 2.6 times for family/work barriers (OR=2.6; 95% CI, 1.3–5.1) to >7 times for access barriers (OR=7.1; 95% CI, 3.9–13.1). Perceived discrimination was the only barrier consistently associated with all 3 utilization outcomes. Conclusions: Multiple types of barriers are associated with delayed and foregone care. System-level barriers and discrimination have the greatest effect on health care seeking behavior.
Tip‐enhanced Raman spectroscopy of carbon nanotubes

This paper presents an overview on the principles of tip-enhanced Raman spectroscopy (TERS). The technique can be used to record Raman images of carbon nanotubes with high spatial resolution. The high resolution is made possible by local enhancement of the incident and scattered fields. The paper also presents some advances on the science of carbon nanotubes generated by TERS, including the observation of local defects, chirality changes, and dopants. Copyright © 2009 John Wiley & Sons, Ltd.
Optical inhibition of striatal neurons promotes focal neurogenesis and neurobehavioral recovery in mice after middle cerebral artery occlusion

Striatal neurons regulate the activity of neural progenitor cells in the subventricular zone, but the effect of striatal neuronal activity on neurogenesis after ischemic stroke is unclear. In this study, we used optogenetic tools to investigate the impact of striatal neuronal activity on the neurogenesis and functional recovery after cerebral ischemia. We transfected striatal neurons with channelrhodopsin-2 or halorhodopsin from Natronomonas so that they can be excited by 473 nm laser or inhibited by 594 nm laser, respectively. Neural inhibition but not excitation at 4–7 days after middle cerebral artery occlusion resulted in reduced atrophy volume (6.8 ± 0.7 vs 8.5 ± 1.2 mm3, p < 0.05) and better performance represented by longer sustaining time on rotarod (99.3 ± 9 vs 80.1 ± 11 s, p < 0.01) and faster moving speed (7.7 ± 2 vs 5.7 ± 1.1 cm/s, p < 0.05) in open field tests. Furthermore, neural inhibition increased the number of nestin+, BrdU+/doublecortin+ and BrdU+/NeuN+ cells (p < 0.001) in the subventricular zone and peri-focal region, and the expression level of axon guidance factor Netrin-1 (0.39 ± 0.16 vs 0.16 ± 0.02, p < 0.05) in the peri-focal region. These data suggest that striatal neuronal activity plays an important role in regulating neurogenesis and neural-behavioral outcomes, and that inhibiting striatal neurons by optogenetics promotes the recovery after ischemic stroke in mice.
A bibliometric model for identifying emerging research topics

Detecting emerging research topics is essential, not only for research agencies but also for individual researchers. Previous studies have created various bibliographic indicators for the identification of emerging research topics. However, as indicated by Rotolo et al. (Research Policy 44, 1827–1843, ), the most serious problems are the lack of an acknowledged definition of emergence and incomplete elaboration of the linkages between the definitions that are used and the indicators that are created. With these issues in mind, this study first adjusts the definition of an emerging technology that Rotolo et al. ( ) have proposed to accommodate the analysis. Next, a set of criteria for the identification of emerging topics is proposed according to the adjusted definition and attributes of emergence. Using two sets of parameter values, several emerging research topics are identified. Finally, evaluation tests are conducted by demonstration of the proposed approach and comparison with previous studies. The strength of the present methodology lies in the fact that it is fully transparent, straightforward, and flexible.
A Finite Element Solution of Lateral Periodic Poisson–Boltzmann Model for Membrane Channel Proteins

Membrane channel proteins control the diffusion of ions across biological membranes. They are closely related to the processes of various organizational mechanisms, such as: cardiac impulse, muscle contraction and hormone secretion. Introducing a membrane region into implicit solvation models extends the ability of the Poisson–Boltzmann (PB) equation to handle membrane proteins. The use of lateral periodic boundary conditions can properly simulate the discrete distribution of membrane proteins on the membrane plane and avoid boundary effects, which are caused by the finite box size in the traditional PB calculations. In this work, we: (1) develop a first finite element solver (FEPB) to solve the PB equation with a two-dimensional periodicity for membrane channel proteins, with different numerical treatments of the singular charges distributions in the channel protein; (2) add the membrane as a dielectric slab in the PB model, and use an improved mesh construction method to automatically identify the membrane channel/pore region even with a tilt angle relative to the z-axis; and (3) add a non-polar solvation energy term to complete the estimation of the total solvation energy of a membrane protein. A mesh resolution of about 0.25 Å (cubic grid space)/0.36 Å (tetrahedron edge length) is found to be most accurate in linear finite element calculation of the PB solvation energy. Computational studies are performed on a few exemplary molecules. The results indicate that all factors, the membrane thickness, the length of periodic box, membrane dielectric constant, pore region dielectric constant, and ionic strength, have individually considerable influence on the solvation energy of a channel protein. This demonstrates the necessity to treat all of those effects in the PB model for membrane protein simulations.
White lupin as a protein source for layers.

Three feeding experiments were conducted with Single Comb White Leghorn hens to determine the effects of Lupinus albus cv. Ultra on performance. Raw, autoclaved, and extruded lupins were fed at 10 and 20% of the diet for 12 wk in Experiment 1. In Experiment 2 raw and extruded lupins were fed at 10, 15, 20, and 25% of the diet for 16 wk. Raw lupin was fed for 32 wk at 10, 15, 20, 25, and 30% of the diet in Experiment 3. Average egg weight, egg production (percent hen-day basis), and feed consumption of hens fed lupins were not significantly different (P greater than .05) from those of hens fed no lupin (basal diet) in Experiments 1 and 2. Haugh unit measurements of eggs from hens fed lupins (Experiment 2) were not significantly different (P greater than .05) from those of hens fed the basal diet (control). Egg production was depressed (P less than .01) in hens fed 30% lupin compared to production of hens fed lower levels of lupin or the basal diet in Experiment 3. Lupin fed at the 15% level or higher in the diet increased (P less than .01) feed consumption of hens in Experiment 3. In all three experiments the average yolk color of eggs from hens fed lupins was significantly higher than that of hens fed the basal diets. Our data indicate that Ultra can serve as a primary protein source when fed to productive hens.
[Use of antibiotics in children during the period 2005 – 16].

Overforbruk av antibiotika øker faren for resistensutvikling, dessuten kan antibiotika ha uheldige konsekvenser for individet både på kort og lang sikt. De tidlige leveår er en spesielt sårbar fase, det er da tarmens mikroflora blir etablert. Vi ønsket å studere antibiotikabruken hos barn i Norge. Vi hentet data fra Reseptregisteret for perioden 2004 – 16 for barn og ungdom < 18 år og undersøkte endring over tid i antall resepter på antibiotika hentet på apotek, delt i undergrupper av antibiotika, barnets alder, kjønn og bostedsfylke. Den samlede antibiotikabruken endret seg lite fra 2005 til 2012, men falt med 24 % fra 2012 til 2016. Med unntak av en økning i tetrasyklinbruken falt forskrivningen for alle typer og mest uttalt for makrolider. Barn under tre år fikk antibiotika vesentlig oftere enn eldre barn. I fylker med høyt forbruk var det 47 % flere utleveringer per barn enn i fylker med lavt forbruk. Bruken av makrolider og kefalosporiner var høy i enkelte fylker. Variasjonen over tid og mellom fylker tyder på at antibiotikaforskrivningen fortsatt kan reduseres. Informasjon til helsepersonell om rasjonell bruk har trolig begrenset forbruket, og informasjon til befolkningen om antibiotika kan være et viktig virkemiddel.
Sex differences in binge‐like EtOH drinking, corticotropin‐releasing hormone and corticosterone: effects of β‐endorphin

Binge drinking is an increasingly common pattern of risky use associated with numerous health problems, including alcohol use disorders. Because low basal plasma levels of β‐endorphin (β‐E) and an increased β‐E response to alcohol are evident in genetically at‐risk human populations, this peptide is thought to contribute to the susceptibility for disordered drinking. Animal models suggest that the effect of β‐E on consumption may be sex‐dependent. Here, we studied binge‐like EtOH consumption in transgenic mice possessing varying levels of β‐E: wild‐type controls with 100% of the peptide (β‐E +/+), heterozygous mice constitutively modified to possess 50% of wild‐type levels (β‐E +/−) and mice entirely lacking the capacity to synthesize β‐E (−/−). These three genotypes and both sexes were evaluated in a 4‐day, two‐bottle choice, drinking in the dark paradigm with limited access to 20% EtOH. β‐E deficiency determined sexually divergent patterns of drinking in that β‐E −/− female mice drank more than their wild‐type counterparts, an effect not observed in male mice. β‐E −/− female mice also displayed elevated basal anxiety, plasma corticosterone and corticotropin‐releasing hormone mRNA in the extended amygdala, and all of these were normalized by EtOH self‐administration. These data suggest that a heightened risk for excessive EtOH consumption in female mice is related to the drug's ability to ameliorate an overactive anxiety/stress‐like state. Taken together, our study highlights a critical impact of sex on neuropeptide regulation of EtOH consumption.
Analysis of the structure - property relations of foam materials

This article describes investigations of the relations between mechanical properties (stiffness and strength) and structure of the cells of foam materials. A new analytical approach based on shell theory was used to study closed cell foams and the finite element method was used to study open cell and closed cell foams. Results were compared with experimentally obtained data for copper and polymethacrylimide foams and with results of prior analytical methods. Experimental results lie within the region bounded by the predicted behaviour of fully closed cell and fully open cell foams.
Endotoxin and dust at respirable and nonrespirable particle sizes are not consistent between cage- and floor-housed poultry operations.

BACKGROUND Individuals engaged in work in intensive animal houses experience some of the highest rates of occupationally related respiratory symptoms. Organic dust and in particular endotoxin has been most closely associated with respiratory symptoms and lung function changes in workers. It has previously been shown that for intensive poultry operations, type of poultry housing [cage-housed (CH) versus floor-housed (FH)] can influence the levels of environmental contaminants. The goal of the study was to determine the differences in endotoxin and dust levels at different size fractions between CH and FH poultry operations. METHODS Fifteen CH and 15 FH poultry operations were sampled for stationary measurements (area) of dust and associated endotoxin. Fractioned samples were collected utilizing Marple cascade impactors. Gravimetric and endotoxin analysis were conducted on each of the filters. RESULTS When assessed by individual Marple stage, there was significantly greater airborne endotoxin concentration (endotoxin units per cubic meter) in the size fraction >9.8 μm for the FH operations whereas at the size fraction 1.6-3.5 μm, the CH operations had significantly greater airborne endotoxin concentration than the FH operations. Endotoxin concentration in the dust mass (endotoxin units per milligram) was significantly greater in the CH operations as compared to the FH operations for all size fractions >1.6 μm. As such, endotoxin in the respirable fraction accounted for 24% of the total endotoxin in the CH operations whereas it accounted for only 11% in the FH operations. There was significantly more dust in all size fractions in the FH operations as compared to the CH poultry operations. CONCLUSIONS There is more endotoxin in the presence of significantly lower dust levels in the respirable particle size fractions in CH poultry operations as compared to the FH poultry operations. This difference in respirable endotoxin may be important in relation to the differential respiratory response experienced by CH and FH poultry operation workers.