Miracle-dz/UniFAR-FTUs huggingface dataset:
Fabrication of 42-Filaments PIT-Processed MgB2 Superconducting Wire With TaB2 and SiC Addition

The high values of MgB2 intrinsic properties, such as the upper critical magnetic field (40 T) and critical temperature (39 K), creates the possibility to use this material for applications in high fields, also due to the low cost of the raw materials. The goal of this paper is to describe a route to produce a 42-filaments MgB2 superconducting wire, from the preparation of the primary powders to the final heat treatment of sinterization. TaB2 and SiC are mixed with the MgB2 powder in an attempt to enhance the flux pinning and the material's transport capacity. The MgB2+additions powder was prepared using high-energy ball milling to mix and refine the grains, and then it was packed inside niobium and MONEL (Cu-Ni) tubes, using the powder-in-tube technique. The final superconducting wire is composed by 42 filaments of MgB2 +additions. The characterization of the samples, heat treated in different temperatures and times, show the microstructure, phase distribution, and microhardness in their cross sections, along with some superconducting properties and characteristics.
MIR137 schizophrenia-associated locus controls synaptic function by regulating synaptogenesis, synapse maturation and synaptic transmission

Abstract The MIR137 locus is a replicated genetic risk factor for schizophrenia. The risk-associated allele is reported to increase miR-137 expression and miR-137 overexpression alters synaptic transmission in mouse hippocampus. We investigated the cellular mechanisms underlying these observed effects in mouse hippocampal neurons in culture. First, we correlated the risk allele to expression of the genes in the MIR137 locus in human postmortem brain. Some evidence for increased MIR137HG expression was observed, especially in hippocampus of the disease-associated genotype. Second, in mouse hippocampal neurons, we confirmed previously observed changes in synaptic transmission upon miR-137 overexpression. Evoked synaptic transmission and spontaneous release were 50% reduced. We identified defects in release probability as the underlying cause. In contrast to previous observations, no evidence was obtained for selective synaptic vesicle docking defects. Instead, ultrastructural morphometry revealed multiple effects of miR-137 overexpression on docking, active zone length and total vesicle number. Moreover, proteomic analyses of neuronal protein showed that expression of Syt1 and Cplx1, previously reported as downregulated upon miR-137 overexpression, was unaltered. Immunocytochemistry of synapses overexpressing miR-137 showed normal Synaptotagmin1 and Complexin1 protein levels. Instead, our proteomic analyses revealed altered expression of genes involved in synaptogenesis. Concomitantly, synaptogenesis assays revealed 31% reduction in synapse formation. Taken together, these data show that miR-137 regulates synaptic function by regulating synaptogenesis, synaptic ultrastructure and synapse function. These effects are plausible contributors to the increased schizophrenia risk associated with miR-137 overexpression.
Experimental study on standard and innovative bolted end-plate beam-to-beam joints under bending

) Abstract. The paper presents the details and results of an experimental study on bolted end-plate joints of industrial type steel building frames. The investigated joints are commonly used in Lindab-Astron industrial buildings and are optimized for manufacturing, erection and durability. The aim of the research was to provide an experimental background for the design model development by studying load-bearing capacity of joints, bolt force distribution, and end-plate deformations. Because of the special joint details, (i.e., joints with four bolts in one bolt-row and HammerHead arrangements), the Eurocode 3 standardized component model had to be improved and extended. The experimental programme included six different end-plate and bolt arrangements and covered sixteen specimens. The steel grade of test specimens was S355, the bolt diameter M20, whereas the bolt grade was 8.8 and 10.9 for the two series. The end-plate thickness varied between 12 mm and 24 mm. The specimens were investigated under pure bending conditions using a four-point-bending test arrangement. In all tests the typical displacements and the bolt force distribution were measured. The end-plate plastic deformations were measured after the tests by an automatic measuring device. The measured data were presented and evaluated by the moment-bolt-row force and moment-distance from centre of compression diagrams and by the deformed end-plate surfaces. From the results the typical failure modes and the joint behaviour were specified and presented. Furthermore the influence of the end-plate thickness and the pretension of the bolts on the behaviour of bolted joints were
I will be there for you: six friends in a clique

Network science has proved useful in analyzing structure and dynamics of social networks in several areas. This paper aims at analyzing the relationships of characters in the sitcom Friends. In particular, two important aspects are investigated. First, how are the structure of the communities (groups)? How different methods for community detection perform? Second, not only static structure of the graphs and causality relationships are investigated, but also temporal aspects. The main findings regarding the centrality and temporal aspects are: patterns in graphs representing different time slices of the show change; overall, degrees of the six friends are indeed nearly the same; however, in different situations (thus graphs), the magnitudes of degree centrality do change; betweenness centrality differs significantly for each character thus some characters are better connectors than others; there is a high difference regarding degrees of the six friends versus the rest of the characters, which points to a centralized network; there are strong indications that the six friends are part of a surrogate family. As for the presence of groups within the network, methods of different natures were investigated aiming at detecting groups (communities) in networks representing different time slices as well as the network of all episodes. Such methods were compared (pairwise and also using various metrics, including plausibility). The multilevel method performs reasonably in general. Also, it stands out that those methods do not agree very much, resulting in groups that are very different from method to method.
Molecular Classification of Grade 3 Endometrioid Endometrial Cancers Identifies Distinct Prognostic Subgroups

Our aim was to investigate whether molecular classification can be used to refine prognosis in grade 3 endometrial endometrioid carcinomas (EECs). Grade 3 EECs were classified into 4 subgroups: p53 abnormal, based on mutant-like immunostaining (p53abn); MMR deficient, based on loss of mismatch repair protein expression (MMRd); presence of POLE exonuclease domain hotspot mutation (POLE); no specific molecular profile (NSMP), in which none of these aberrations were present. Overall survival (OS) and recurrence-free survival (RFS) rates were compared using the Kaplan-Meier method (Log-rank test) and univariable and multivariable Cox proportional hazard models. In total, 381 patients were included. The median age was 66 years (range, 33 to 96 y). Federation Internationale de Gynecologie et d'Obstetrique stages (2009) were as follows: IA, 171 (44.9%); IB, 120 (31.5%); II, 24 (6.3%); III, 50 (13.1%); IV, 11 (2.9%). There were 49 (12.9%) POLE, 79 (20.7%) p53abn, 115 (30.2%) NSMP, and 138 (36.2%) MMRd tumors. Median follow-up of patients was 6.1 years (range, 0.2 to 17.0 y). Compared to patients with NSMP, patients with POLE mutant grade 3 EEC (OS: hazard ratio [HR], 0.36 [95% confidence interval, 0.18-0.70]; P=0.003; RFS: HR, 0.17 [0.05-0.54]; P=0.003) had a significantly better prognosis; patients with p53abn tumors had a significantly worse RFS (HR, 1.73 [1.09-2.74]; P=0.021); patients with MMRd tumors showed a trend toward better RFS. Estimated 5-year OS rates were as follows: POLE 89%, MMRd 75%, NSMP 69%, p53abn 55% (Log rank P=0.001). Five-year RFS rates were as follows: POLE 96%, MMRd 77%, NSMP 64%, p53abn 47% (P=0.000001), respectively. In a multivariable Cox model that included age and Federation Internationale de Gynecologie et d'Obstetrique stage, POLE and MMRd status remained independent prognostic factors for better RFS; p53 status was an independent prognostic factor for worse RFS. Molecular classification of grade 3 EECs reveals that these tumors are a mixture of molecular subtypes of endometrial carcinoma, rather than a homogeneous group. The addition of molecular markers identifies prognostic subgroups, with potential therapeutic implications.
Cone-beam computed tomography in the assessment of periapical lesions in endodontically treated teeth

ABSTRACT Objective: This study aimed to evaluate the relationship between the quality of the coronal restoration and the root canal filling on the periapical status of endodontically treated teeth using CBCT. Materials and Methods: CBCT data were obtained from the records of patients who deny any dental treatment in the 2 years prior to the CBCT examination. CBCT images (90 kVp and 7 mA, exposure time of 23 s, and a voxel size of 0.2 mm, with a field of view of 13 cm x 13 cm) of 1011 endodontically treated teeth were observed. A score was given to the quality of the root filling and the quality of the coronal restoration. Statistical Analysis Used: Data were statistically analyzed to correlate the periapical status with gender, dental group. and quality of endodontic treatment and restoration (Chi-square test with a significance level of P < 0.001). Results: Absence of periapical periodontitis was found in 54.9% of the cases. The periapical outcome was not related to gender or dental group (P > 0.05). A statistically significant factor (Chi-square test, P < 0.0001) resulted when different qualities of sealing were compared. Conclusions: CBCT showed that high-quality root canal treatments followed by an adequate coronal sealing restoration avoid the presence of periapical periodontitis in time.
The characterization of surgical smoke from various tissues and its implications for occupational safety

Electrosurgery produces surgical smoke. Different tissues produce different quantities and types of smoke, so we studied the particle characteristics of this surgical smoke in order to analyze the implications for the occupational health of the operation room personnel. We estimated the deposition of particulate matter (PM) from surgical smoke on the respiratory tract of operation room personnel using clinically relevant tissues from Finnish landrace porcine tissues including skeletal muscle, liver, subcutaneous fat, renal pelvis, renal cortex, lung, bronchus, cerebral gray and white matter, and skin. In order to standardize the electrosurgical cuts and smoke concentrations, we built a customized computer-controlled platform. The smoke particles were analyzed with an electrical low pressure impactor (ELPI), which measures the concentration and aerodynamic size distribution of particles with a diameter between 7 nm and 10 μm. There were significant differences in the mass concentration and size distribution of the surgical smoke particles depending on the electrocauterized tissue. Of the various tissues tested, liver yielded the highest number of particles. In order to better estimate the health hazard, we propose that the tissues can be divided into three distinct classes according to their surgical smoke production: 1) high-PM tissue for liver; 2) medium-PM tissues for renal cortex, renal pelvis, and skeletal muscle; and 3) low-PM tissues for skin, gray matter, white matter, bronchus, and subcutaneous fat.
The Disease Burden and the Extent of Drug Therapy Problems in an Underserved Minority Population Receiving Medication Therapy Management at an Ambulatory Care Free Clinic

Objective: To determine the common medical conditions, medications, and associated drug therapy problems in an underserved minority population receiving medication therapy management services at a large Community Free Clinic compared to the findings of the Minnesota Pharmaceutical Care Project. Methods: Retrospective cohort study of a random sample of 60 minority patients referred for medication therapy management service at a Community Free Clinic from January 2012 to January 2014. Patient data including demographics, medication experience, past medical and medication history, medical conditions, active medications, allergies, immunization history and drug therapy was systematically evaluated to determine the most common conditions, and any drug therapy problems present, compared to findings of the Minnesota Pharmaceutical Care Project . The data was analyzed using descriptive statistics. Results: 25 (73%) patients were 51 years and older of which 73% female. The top most common medical conditions were hypertension, Type II diabetes mellitus, and dyslipidemia. The most common medications were antihypertensive, oral anti-diabetic and non-steroidal anti-inflammatory drugs. Needs additional drug therapy (48.9%), Dosage too low (16.3%) and Non-adherence (11.6%) were the leading drug therapy problems identified. Conclusion: Hypertension, type II diabetes and dyslipidemia were the leading chronic medical conditions whereas Needs Additional Drug Therapy, Dosage Too Low and Non-Compliance were the associated most common drug therapy problems in the minority population. These results were comparable to the findings among the general population in the Minnesota Pharmaceutical Care Project.
The effects of memory training on behavioral and microstructural plasticity in young and older adults

Age differences in human brain plasticity are assumed, but have not been systematically investigated. In this longitudinal study, we investigated changes in white matter (WM) microstructure in response to memory training relative to passive and active control conditions in 183 young and older adults. We hypothesized that (i) only the training group would show improved memory performance and microstructural alterations, (ii) the young adults would show larger memory improvement and a higher degree of microstructural alterations as compared to the older adults, and (iii) changes in memory performance would relate to microstructural alterations. The results showed that memory improvement was specific to the training group, and that both the young and older participants improved their performance. The young group improved their memory to a larger extent compared to the older group. In the older sample, the training group showed less age‐related decline in WM microstructure compared to the control groups, in areas overlapping the corpus callosum, the cortico‐spinal tract, the cingulum bundle, the superior longitudinal fasciculus, and the anterior thalamic radiation. Less microstructural decline was related to a higher degree of memory improvement. Despite individual adaptation securing sufficient task difficulty, no training‐related group differences in microstructure were found in the young adults. The observed divergence of behavioral and microstructural responses to memory training with age is discussed within a supply‐demand framework. The results demonstrate that plasticity is preserved into older age, and that microstructural alterations may be part of a neurobiological substrate for behavioral improvements in older adults. Hum Brain Mapp 38:5666–5680, 2017. © 2018 The Authors Human Brain Mapping Published byWiley Periodicals, Inc.
Polarized NIR and X-ray flares from Sagittarius A*

Context. Stellar dynamics indicate the presence of a supermassive 3−4 × 10 6 Mblack hole at the Galactic Center. It is associated with the variable radio, near-infrared, and X-ray source Sagittarius A* (SgrA*). Aims. The goal is the investigation and understanding of the physical processes responsible for the variable emission from SgrA*. Methods. The observations have been carried out using the NACO adaptive optics (AO) instrument at the European Southern Observatory's Very Large Telescope (July 2005, May 2007) and the ACIS-I instrument aboard the Chandra X-ray Observatory (July 2005). Results. We find that for the July 2005 flare the variable and polarized NIR emission of SgrA* occurred synchronous with a moder- ately bright flare event in the X-ray domain with an excess 2−8 keV luminosity of about 8 × 10 33 erg/s. We find no time lag between the flare events in the two wavelength bands with a lower limit of ≤10 min. The May 2007 flare shows the highest sub-flare to flare contrast observed until now. It provides evidence for a variation in the profile of consecutive sub-flares. Conclusions. We confirm that highly variable and NIR polarized flare emission is non-thermal and that there exists a class of syn- chronous NIR/X-ray flares. We find that the flaring state can be explained via the synchrotron self-Compton (SSC) process involving up-scattered X-rays from the compact source component. The observations can be interpreted in a model involving a temporary disk with a short jet. In the disk component the flux density variations can be explained by spots on relativistic orbits around the central supermassive black hole (SMBH). The profile variations for the May 2007 flare can be interpreted as a variation of the spot structure due to differential rotation within the disk.
A case of posterior cortical atrophy with vertical neglect

ABSTRACT Posterior cortical atrophy (PCA) is a syndrome caused by a neurodegenerative disease that often presents with visuospatial deficits, and can be debilitating. PCA is often characterized by elements of Balint’s syndrome and dyslexia. The most common underlying pathology has been found to be Alzheimer’s disease. Signs of horizontal neglect are frequently associated with PCA, but the presence of vertical (or altitudinal) neglect has not yet been reported in a patient with PCA or other forms of neurodegenerative dementia. In this paper, we present a patient with PCA who on vertical line bisection and cancellation tests revealed upper altitudinal spatial neglect. Detection of this abnormality may have important implications for diagnosis, therapeutic interventions, and patient safety.
Radar and RGB-Depth Sensors for Fall Detection: A Review

This paper reviews recent works in the literature on the use of systems based on radar and RGB-Depth (RGB-D) sensors for fall detection, and discusses outstanding research challenges and trends related to this research field. Systems to detect reliably fall events and promptly alert carers and first responders have gained significant interest in the past few years in order to address the societal issue of an increasing number of elderly people living alone, with the associated risk of them falling and the consequences in terms of health treatments, reduced well-being, and costs. The interest in radar and RGB-D sensors is related to their capability to enable contactless and non-intrusive monitoring, which is an advantage for practical deployment and users’ acceptance and compliance, compared with other sensor technologies, such as video-cameras, or wearables. Furthermore, the possibility of combining and fusing information from The heterogeneous types of sensors is expected to improve the overall performance of practical fall detection systems. Researchers from different fields can benefit from multidisciplinary knowledge and awareness of the latest developments in radar and RGB-D sensors that this paper is discussing.
A simple approach to CO cooling in molecular clouds

CO plays an important role in interstellar molecular clouds, both as a coolant, and as a diagnostic molecule. However, a proper evaluation of the cooling rate due to CO requires a determination of the populations of many levels, the spontaneous and stimulated radiative de-excitation rates between these levels, and the transfer of the emitted multi-line radiation; additionally, this must be done for three isotopologues. It would be useful to have a simple analytic formulation that avoided these complications; this could then be used in situations where CO plays an important role as a coolant, but the details of this role are not the main concern. We derive such a formulation here, by first considering the two asymptotic forms that obtain in the limits of (a) low volume-density and optical depth, and (b) high volume-density and optical depth. These forms are then combined in such a way as to fit the detailed numerical results from Goldsmith \& Langer (1978), which cover low temperatures, and a range of physical conditions where the interplay of thermal and sub-thermal excitation, optical-depth effects, and the contributions from rare isotopologues, are all important. The fit is obtained using the Metropolis-Hastings method, and reproduces the results of GL78 well. It is a purely local and analytic function of state --- specifically a function of the density, $\rho$, isothermal sound speed, $a$, CO abundance, $X_{_{\rm CO}}$, and velocity divergence, $\nabla\cdot{\boldsymbol\upsilon}$. As an application, we consider the cooling layer following a slow steady non-magnetic planar J-shock. We show that, if the post-shock cooling is dominated by CO and its isotopologues, the thickness of the post-shock cooling layer is very small and approximately independent of the pre-shock velocity, $\upsilon_o$, or pre-shock isothermal sound speed, $a_o$.
Mutagenesis of S-Adenosyl-l-Methionine-Binding Residues in Coronavirus nsp14 N7-Methyltransferase Demonstrates Differing Requirements for Genome Translation and Resistance to Innate Immunity

ABSTRACT Eukaryotic mRNAs possess a methylated 5′-guanosine cap that is required for RNA stability, efficient translation, and protection from cell-intrinsic defenses. Many viruses use 5′ caps or other mechanisms to mimic a cap structure to limit detection of viral RNAs by intracellular innate sensors and to direct efficient translation of viral proteins. The coronavirus (CoV) nonstructural protein 14 (nsp14) is a multifunctional protein with N7-methyltransferase (N7-MTase) activity. The highly conserved S-adenosyl-l-methionine (SAM)-binding residues of the DxG motif are required for nsp14 N7-MTase activity in vitro. However, the requirement for CoV N7-MTase activity and the importance of the SAM-binding residues during viral replication have not been determined. Here, we engineered mutations in murine hepatitis virus (MHV) nsp14 N7-MTase at residues D330 and G332 and determined the effects of these mutations on viral replication, sensitivity to mutagen, inhibition by type I interferon (IFN), and translation efficiency. Virus encoding a G332A substitution in nsp14 displayed delayed replication kinetics and decreased peak titers relative to wild-type (WT) MHV. In addition, replication of nsp14 G332A virus was diminished following treatment of cells with IFN-β, and nsp14 G332A genomes were translated less efficiently both in vitro and during viral infection. In contrast, substitution of alanine at MHV nsp14 D330 did not affect viral replication, sensitivity to mutagen, or inhibition by IFN-β compared to WT MHV. Our results demonstrate that the conserved MHV N7-MTase SAM-binding-site residues are not required for MHV viability and suggest that the determinants of CoV N7-MTase activity differ in vitro and during virus infection. IMPORTANCE Human coronaviruses, most notably severe acute respiratory syndrome (SARS)-CoV and Middle East respiratory syndrome (MERS)-CoV, cause severe and lethal human disease. Since specific antiviral therapies are not available for the treatment of human coronavirus infections, it is essential to understand the functions of conserved CoV proteins in viral replication. Here, we show that substitution of alanine at G332 in the N7-MTase domain of nsp14 impairs viral replication, enhances sensitivity to the innate immune response, and reduces viral RNA translation efficiency. Our data support the idea that coronavirus RNA capping could be targeted for development of antiviral therapeutics.