Miracle-dz/UniFAR-FTUs huggingface dataset:
Evolutionary Robotics: What, Why, and Where to

Evolutionary robotics applies the selection, variation, and heredity principles of natural evolution to the design of robots with embodied intelligence. It can be considered as a subfield of robotics that aims to create more robust and adaptive robots. A pivotal feature of the evolutionary approach is that it considers the whole robot at once, and enables the exploitation of robot features in a holistic manner. Evolutionary robotics can also be seen as an innovative approach to the study of evolution based on a new kind of experimentalism. The use of robots as a substrate can help address questions that are difficult, if not impossible, to investigate through computer simulations or biological studies. In this paper we consider the main achievements of evolutionary robotics, focusing particularly on its contributions to both engineering and biology. We briefly elaborate on methodological issues, review some of the most interesting findings, and discuss important open issues and promising avenues for future work.
Robust Cross-Lingual Hypernymy Detection Using Dependency Context

Cross-lingual Hypernymy Detection involves determining if a word in one language (“fruit”) is a hypernym of a word in another language (“pomme” i.e. apple in French). The ability to detect hypernymy cross-lingually can aid in solving cross-lingual versions of tasks such as textual entailment and event coreference. We propose BiSparse-Dep, a family of unsupervised approaches for cross-lingual hypernymy detection, which learns sparse, bilingual word embeddings based on dependency contexts. We show that BiSparse-Dep can significantly improve performance on this task, compared to approaches based only on lexical context. Our approach is also robust, showing promise for low-resource settings: our dependency-based embeddings can be learned using a parser trained on related languages, with negligible loss in performance. We also crowd-source a challenging dataset for this task on four languages – Russian, French, Arabic, and Chinese. Our embeddings and datasets are publicly available.
A common ancestral DNMT3A-mutated preleukemic clone giving rise to AML and MDS in an adolescent girl

Gudrun G€ ohring*, Kathrin Thomay*, Gunnar Schmidt, Tim Ripperger, Michael Xu, Nicole Wittner, Mwe Mwe Chao, Irith Baumann, Marena Niewisch, Dirk Reinhardt, Thomas Klingebiel, Felicitas Thol, Brigitte Schlegelberger and Charlotte M. Niemeyer Institute of Human Genetics, Hannover Medical School, Hannover, Germany; Manitoba Institute of Cell Biology, CancerCare Manitoba, Winnipeg, Canada; Department of Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany; Department of Pathology, Clinical Center, B€oblingen, Germany; Division of Pediatric Hematology and Oncology, Department of Pediatrics, University Medical Center Freiburg, Freiburg, Germany; Clinic for Pediatrics III, University Hospital Essen, Essen, Germany; Hospital for Children and Adolescents, University Hospital Frankfurt, Frankfurt, Germany; Department of Hematology, Hemostasis, Oncology and SCT, Hannover Medical School, Hannover, Germany
Comparison of bioartificial and artificial pancreatic transplantation as promising therapies for Type I Diabetes Mellitus

Type 1 diabetes mellitus (T1DM) is a chronic life-threatening condition whose incidence in the UK has doubled every 20 years since 1945 (Diabetes UK, 2010). Whilst intensive insulin therapy has been shown to reduce the incidence of long-term vascular complications in T1DM patients, it has also been shown to increase the risk of severe hypoglycaemia by 3-fold. Clinical islet transplantation has progressed considerably over the past decade, yet issues regarding the toxic effects of immunosuppression drugs and the paucity of pancreatic donor supplies remain. To provide an effective long-term therapy for heightened glycaemic control, many studies are investigating the potential of bioartificial islet encapsulation strategies and artificial bihormonal closed-loop systems. Following consideration of the basis of pancreatic transplantation, this article takes an indepth look at both the benefits and limitations of bioartificial and artificial therapies and compares their potential in terms of providing an effective long-term solution to patients suffering with T1DM.
Behaviour of Biodegradable Films Used for Mulching in Melon Cultivation

Many of the most important crops of the Region of Murcia (SE Spain) are grown semi-protected. One such crop, which has 7,000 ha dedicated to its cultivation, is melon. As in the case of many crops, transparent polyethylene mulching is used to increase soil temperature and therefore to bring forward harvesting. The mulch is normally left on the ground at the end of the growth cycle since it is difficult to recycle. Emerging biodegradable materials for mulching might be an alternative solution to polyethylene as long as the same thermal and mechanical features as the traditionally used material could be guaranteed. Such materials would begin to degrade as the harvest was finishing, totally decomposing later. The aim of our research was to evaluate the behaviour of four biodegradable materials and one LLDPE in the open-air cultivation of a Spanish melon cultivar in Mediterranean environmental conditions during the normal growing season for this crop (spring-summer). The results obtained show that the use of biodegradable materials produced similar yields than LLDPE. However, the biodegradable materials had disappeared 5–6 months after putting on position, whereas LLDPE remained in the ground.
Depletion of Tumor-Associated Macrophages with a CSF-1R Kinase Inhibitor Enhances Antitumor Immunity and Survival Induced by DC Immunotherapy

Mesothelioma has a poor prognosis and resists conventional therapies. Although tumor-associated macrophage depletion alone cannot restore antitumor immunity, its combination with dendritic cell–based therapy enhanced immune activation and survival in mesothelioma tumor models. New immunotherapeutic strategies are needed to induce effective antitumor immunity in all cancer patients. Malignant mesothelioma is characterized by a poor prognosis and resistance to conventional therapies. Infiltration of tumor-associated macrophages (TAM) is prominent in mesothelioma and is linked to immune suppression, angiogenesis, and tumor aggressiveness. Therefore, TAM depletion could potentially reactivate antitumor immunity. We show that M-CSFR inhibition using the CSF-1R kinase inhibitor PLX3397 (pexidartinib) effectively reduced numbers of TAMs, circulating nonclassical monocytes, as well as amount of neoangiogenesis and ascites in mesothelioma mouse models, but did not improve survival. When combined with dendritic cell vaccination, survival was synergistically enhanced with a concomitant decrease in TAMs and an increase in CD8+ T-cell numbers and functionality. Total as well as tumor antigen–specific CD8+ T cells in tumor tissue of mice treated with combination therapy showed reduced surface expression of the programmed cell death protein-1 (PD-1), a phenomenon associated with T-cell exhaustion. Finally, mice treated with combination therapy were protected from tumor rechallenge and displayed superior T-cell memory responses. We report that decreasing local TAM-mediated immune suppression without immune activation does not improve survival. However, combination of TAM-mediated immune suppression with dendritic cell immunotherapy generates robust and durable antitumor immunity. These findings provide insights into the interaction between immunotherapy-induced antitumor T cells and TAMs and offer a therapeutic strategy for mesothelioma treatment. Cancer Immunol Res; 5(7); 535–46. ©2017 AACR.
Diabetes, Abnormal Glucose, Dyslipidemia, Hypertension, and Risk of Inflammatory and Other Breast Cancer

Background: Obesity has been associated with substantially higher risk of inflammatory breast cancer (IBC) than other breast cancer. Here, we assess whether comorbidities of obesity, namely diabetes, abnormal glucose, dyslipidemia, and hypertension, are differentially related to risk of IBC and other breast cancers by tumor stage at diagnosis (localized/regional/distant/unstaged). Methods: We used linked SEER-Medicare data, with female breast cancer cases ages 66+ years identified by SEER registries (years 1992–2011). We divided first breast cancers into IBC (N = 2,306), locally advanced non-IBC (LABC; N = 10,347), and other (N = 197,276). We selected female controls (N = 200,000) from a stratified 5% random sample of Medicare recipients alive and breast cancer free. We assessed exposures until 12 months before diagnosis/selection using Medicare claims data. We estimated odds ratios (OR) and 99.9% confidence intervals (CI) using unconditional logistic regression. Results: Diabetes was associated with increased risk of distant IBC (98.5% of IBC cases; OR 1.44; 99.9% CI 1.21–1.71), distant (OR 1.24; 99.9% CI, 1.09–1.40) and regional (OR 1.29 (99.9% CI, 1.14–1.45) LABC, and distant (OR 1.23; 99.9% CI, 1.10–1.39) and unstaged (OR 1.32; 99.9% CI, 1.18–1.47) other breast cancers. Dyslipidemia was associated with reduced risk of IBC (OR 0.80; 95% CI, 0.67–0.94) and other breast cancers except localized disease. Results were similar by tumor estrogen receptor status. Abnormal glucose levels and hypertension had little association with risk of any tumor type. Conclusions: Associations with diabetes and dyslipidemia were similar for distant stage IBC and other advanced tumors. Impact: If confirmed, such findings could suggest avenues for prevention. Cancer Epidemiol Biomarkers Prev; 26(6); 862–8. ©2017 AACR.
Current perspectives on antibody-mediated rejection after lung transplantation

License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at: http://www.dovepress. com/permissions.php Transplant Research and Risk Management 2014:6 109–115 Transplant Research and Risk Management Dovepress
A Multi-Center Randomised Controlled Trial of Gatifloxacin versus Azithromycin for the Treatment of Uncomplicated Typhoid Fever in Children and Adults in Vietnam

Background Drug resistant typhoid fever is a major clinical problem globally. Many of the first line antibiotics, including the older generation fluoroquinolones, ciprofloxacin and ofloxacin, are failing. Objectives We performed a randomised controlled trial to compare the efficacy and safety of gatifloxacin (10 mg/kg/day) versus azithromycin (20 mg/kg/day) as a once daily oral dose for 7 days for the treatment of uncomplicated typhoid fever in children and adults in Vietnam. Methods An open-label multi-centre randomised trial with pre-specified per protocol analysis and intention to treat analysis was conducted. The primary outcome was fever clearance time, the secondary outcome was overall treatment failure (clinical or microbiological failure, development of typhoid fever-related complications, relapse or faecal carriage of S. typhi). Principal Findings We enrolled 358 children and adults with suspected typhoid fever. There was no death in the study. 287 patients had blood culture confirmed typhoid fever, 145 patients received gatifloxacin and 142 patients received azithromycin. The median FCT was 106 hours in both treatment arms (95% Confidence Interval [CI]; 94–118 hours for gatifloxacin versus 88–112 hours for azithromycin), (logrank test p = 0.984, HR [95% CI] = 1.0 [0.80–1.26]). Overall treatment failure occurred in 13/145 (9%) patients in the gatifloxacin group and 13/140 (9.3%) patients in the azithromycin group, (logrank test p = 0.854, HR [95% CI] = 0.93 [0.43–2.0]). 96% (254/263) of the Salmonella enterica serovar Typhi isolates were resistant to nalidixic acid and 58% (153/263) were multidrug resistant. Conclusions Both antibiotics showed an excellent efficacy and safety profile. Both gatifloxacin and azithromycin can be recommended for the treatment of typhoid fever particularly in regions with high rates of multidrug and nalidixic acid resistance. The cost of a 7-day treatment course of gatifloxacin is approximately one third of the cost of azithromycin in Vietnam. Trial Registration Controlled-Trials.com ISRCTN67946944
The influence of cycles of freezing and thawing on the compressive property of concrete in seawater

The compressive tests of concrete specimens suffering 0、25、50、75 and 100 cycles of freezing and thawing respectively in 3.5% sodium chloride solution imitated seawater were completed,using the large static-dynamic triaxial test system for concrete.The influence of cycles of freezing and thawing on the compressive strength of concrete,elastic modulus and stress-strain relationship is tested,and the concise mathematics formula is established.The conclusions can provide the testing and theoretic basis for the deeper study of the concrete construction in northern cold region or nearby the coastal and offshore influenced by cycles of freezing and thawing.
IRS-2 Deficiency Impairs NMDA Receptor-Dependent Long-term Potentiation

The beneficial effects of insulin and insulin-like growth factor I on cognition have been documented in humans and animal models. Conversely, obesity, hyperinsulinemia, and diabetes increase the risk for neurodegenerative disorders including Alzheimer's disease (AD). However, the mechanisms by which insulin regulates synaptic plasticity are not well understood. Here, we report that complete disruption of insulin receptor substrate 2 (Irs2) in mice impairs long-term potentiation (LTP) of synaptic transmission in the hippocampus. Basal synaptic transmission and paired-pulse facilitation were similar between the 2 groups of mice. Induction of LTP by high-frequency conditioning tetanus did not activate postsynaptic N-methyl-D-aspartate (NMDA) receptors in hippocampus slices from Irs2−/− mice, although the expression of NR2A, NR2B, and PSD95 was equivalent to wild-type controls. Activation of Fyn, AKT, and MAPK in response to tetanus stimulation was defective in Irs2−/− mice. Interestingly, IRS2 was phosphorylated during induction of LTP in control mice, revealing a potential new component of the signaling machinery which modulates synaptic plasticity. Given that IRS2 expression is diminished in Type 2 diabetics as well as in AD patients, these data may reveal an explanation for the prevalence of cognitive decline in humans with metabolic disorders by providing a mechanistic link between insulin resistance and impaired synaptic transmission.
Pervasive Local-Scale Tree-Soil Habitat Association in a Tropical Forest Community

We examined tree-soil habitat associations in lowland forest communities at Paracou, French Guiana. We analyzed a large dataset assembling six permanent plots totaling 37.5 ha, in which extensive LIDAR-derived topographical data and soil chemical and physical data have been integrated with precise botanical determinations. Map of relative elevation from the nearest stream summarized both soil fertility and hydromorphic characteristics, with seasonally inundated bottomlands having higher soil phosphate content and base saturation, and plateaus having higher soil carbon, nitrogen and aluminum contents. We employed a statistical test of correlations between tree species density and environmental maps, by generating Monte Carlo simulations of random raster images that preserve autocorrelation of the original maps. Nearly three fourths of the 94 taxa with at least one stem per ha showed a significant correlation between tree density and relative elevation, revealing contrasted species-habitat associations in term of abundance, with seasonally inundated bottomlands (24.5% of species) and well-drained plateaus (48.9% of species). We also observed species preferences for environments with or without steep slopes (13.8% and 10.6%, respectively). We observed that closely-related species were frequently associated with different soil habitats in this region (70% of the 14 genera with congeneric species that have a significant association test) suggesting species-habitat associations have arisen multiple times in this tree community. We also tested if species with similar habitat preferences shared functional strategies. We found that seasonally inundated forest specialists tended to have smaller stature (maximum diameter) than species found on plateaus. Our results underline the importance of tree-soil habitat associations in structuring diverse communities at fine spatial scales and suggest that additional studies are needed to disentangle community assembly mechanisms related to dispersal limitation, biotic interactions and environmental filtering from species-habitat associations. Moreover, they provide a framework to generalize across tropical forest sites.
Clinical experience using a video‐guided spirometry system for deep inhalation breath‐hold radiotherapy of left‐sided breast cancer

The purpose was to report clinical experience of a video‐guided spirometry system in applying deep inhalation breath‐hold (DIBH) radiotherapy for left‐sided breast cancer, and to study the systematic and random uncertainties, intra‐ and interfraction motion and impact on cardiac dose associated with DIBH. The data from 28 left‐sided breast cancer patients treated with spirometer‐guided DIBH radiation were studied. Dosimetric comparisons between free‐breathing (FB) and DIBH plans were performed. The distance between the heart and chest wall measured on the digitally reconstructed radiographs (DRR) and MV portal images, dDRR(DIBH) and dport(DIBH), respectively, was compared as a measure of DIBH setup uncertainty. The difference (Δd) between dDRR(DIBH) and dport(DIBH) was defined as the systematic uncertainty. The standard deviation of Δd for each patient was defined as the random uncertainty. MV cine images during radiation were acquired. Affine registrations of the cine images acquired during one fraction and multiple fractions were performed to study the intra‐ and interfraction motion of the chest wall. The median chest wall motion was used as the metric for intra‐ and interfraction analysis. Breast motions in superior–inferior (SI) direction and “AP” (defined on the DRR or MV portal image as the direction perpendicular to the SI direction) are reported. Systematic and random uncertainties of 3.8 mm and 2 mm, respectively, were found for this spirometer‐guided DIBH treatment. MV cine analysis showed that intrafraction chest wall motions during DIBH were 0.3 mm in “AP” and 0.6 mm in SI. The interfraction chest wall motions were 3.6 mm in “AP” and 3.4 mm in SI. Utilization of DIBH with this spirometry system led to a statistically significant reduction of cardiac dose relative to FB treatment. The DIBH using video‐guided spirometry provided reproducible cardiac sparing with minimal intra‐ and interfraction chest wall motion, and thus is a valuable adjunct to modern breast treatment techniques. PACS number: 87.55. kh, 87.55. ne, 87.55. tg
Examining Dark Triad traits in relation to mental toughness and physical activity in young adults

Objective The Dark Triad (DT) describes a set of three closely related personality traits: Machiavellianism, narcissism, and psychopathy. Mental toughness (MT) refers to a psychological construct combining confidence, commitment, control, and challenge. High MT is related to greater physical activity (PA) and, relative to men, women have lower MT scores. The aims of the present study were 1) to investigate the association between DT, MT, and PA, and 2) to compare the DT, MT, and PA scores of men and women. Methods A total of 341 adults (M=29 years; 51.6% women; range: 18–37 years) took part in the study. Participants completed a series of questionnaires assessing DT, MT, and PA. Results Machiavellianism, narcissism, and psychopathy were all significantly associated with higher MT scores (rs =0.45, 0.50, and 0.20, respectively). DT traits and MT were associated with more vigorous PA. Compared to men, women participants had lower scores for DT traits (overall score and psychopathy), while no differences were found for MT or PA in both sexes. Conclusion DT traits, high MT, and vigorous PA are interrelated. This pattern of results might explain why, for instance, successful professional athletes can at the same time be tough and ruthless.
Improved method to determine radio-echo sounding reflector depths from ice-core profiles of permittivity and conductivity

We present a technique that modifies and extends down-hole target methods to provide absolute measures of uncertainty in radar-reflector depth of origin. We use ice-core profiles to model wave propagation and reflection, and then cross-correlate the model results with radio-echo sounding (RES) data to identify the depth of reflector events. Stacked traces recorded with RES near the EPICA drill site in Dronning Maud Land, Antarctica, provide reference radargrams, and dielectric properties along the deep ice core form the input data to a forward model of wave propagation that produces synthetic radargrams. Cross-correlations between synthetic and RES radargrams identify differences in propagation wave speed. They are attributed to uncertainties in pure-ice permittivity and are used for calibration. Removing conductivity peaks results in the disappearance of related synthetic reflections and enables the unambiguous relation of electric signatures to RES features. We find that (i) density measurements with }-attenuation or dielectric profiling are too noisy below the firn-ice transition to allow clear identification of reflections, (ii) single conductivity peaks less than 0.5 m wide cause the majority of prominent reflections beyond a travel time of about 10 μs (∼900 m depth) and (iii) some closely spaced conductivity peaks within a range of 1-2m cannot be resolved within the RES or synthetic data. Our results provide a depth accuracy to allow synchronization of age-depth profiles of ice cores by RES, modeling of isochronous internal structures, and determination of wave speed and of pure-ice properties. The technique successfully operates with dielectric profiling and electrical conductivity measurements, suggesting that it can be applied at other ice cores and drill sites.
Attentive Generative Adversarial Network for Raindrop Removal from A Single Image

Raindrops adhered to a glass window or camera lens can severely hamper the visibility of a background scene and degrade an image considerably. In this paper, we address the problem by visually removing raindrops, and thus transforming a raindrop degraded image into a clean one. The problem is intractable, since first the regions occluded by raindrops are not given. Second, the information about the background scene of the occluded regions is completely lost for most part. To resolve the problem, we apply an attentive generative network using adversarial training. Our main idea is to inject visual attention into both the generative and discriminative networks. During the training, our visual attention learns about raindrop regions and their surroundings. Hence, by injecting this information, the generative network will pay more attention to the raindrop regions and the surrounding structures, and the discriminative network will be able to assess the local consistency of the restored regions. This injection of visual attention to both generative and discriminative networks is the main contribution of this paper. Our experiments show the effectiveness of our approach, which outperforms the state of the art methods quantitatively and qualitatively.