Miracle-dz/UniFAR-FTUs huggingface dataset:
125I-alpha-conotoxin MII identifies a novel nicotinic acetylcholine receptor population in mouse brain.

alpha-Conotoxin MII (CtxMII), a peptide toxin from the venom of the predatory cone snail Conus magus, displays an unusual nicotinic pharmacology. Specific binding of a radioiodinated derivative ((125)I-alpha-CtxMII) was identified in brain region homogenates and tissue sections. Quantitative autoradiography indicated that (125)I-alpha-CtxMII binding sites have an unique pharmacological profile and distribution in mouse brain, being largely confined to the superficial layers of the superior colliculus, nigrostriatal pathway, optic tract, olivary pretectal, and mediolateral and dorsolateral geniculate nuclei. Expression of alpha-CtxMII binding sites in the nigrostriatal pathway, combined with evidence for alpha-CtxMII-sensitivity of nicotine-induced [(3)H]dopamine release in rodent striatal preparations indicates that (125)I-alpha-CtxMII binding nicotinic acetylcholine receptors are likely to be physiologically important. Unlabeled alpha-CtxMII potently (K(i) < 3 nM) competed for a subset of [(3)H]epibatidine binding sites in mouse brain homogenates, but weakly (IC(50) > 10 microM) interacted with (125)I-alpha-bungarotoxin and (-)-[(3)H]nicotine binding sites, confirming this compound's novel nicotinic pharmacology. Quantitative autoradiography revealed that alpha-CtxMII binds with high affinity at a subset of [(3)H]epibatidine binding sites with relatively low cytisine affinity ("cytisine-resistant" sites), resolving [(3)H]epibatidine binding into three different populations, each probably corresponding to a receptor subtype. The majority population seems to correspond to that which binds nicotine and cytisine with high affinity ("cytisine-sensitive" sites). Comparison of the cytisine-resistant population's distribution with that of alpha3 subunit mRNA expression suggests that the fractions both more and less sensitive to alpha-CtxMII probably contain the alpha3 subunit, perhaps in combination with different beta subunits.
Performance comparison of MC-CDMA and cyclically prefixed DS-CDMA in an uplink channel [mobile radio]

This paper compares multi-carrier code division multiple access (MC-CDMA) with cyclically prefixed direct sequence CP-DS-CDMA in an uplink channel. For the CP-DS-CDMA scheme, we propose an MMSE-based multi-user detection (MUD) technique, which recovers code orthogonality among users destroyed by frequency-selective fading in the frequency domain. On the other hand, it is well known that the peak to power average ratio (PAPR) of a single carrier transmission scheme is lower than that of a multi-carrier transmission scheme. Thus, from the viewpoint of the PAPR issue, this paper studies the effect of resolution bits of the digital to analog converter (DAC) at the transmitter and the analog to digital converter (ADC) at the receiver on both schemes. Then, this paper evaluates the performance of the two schemes by computer simulations.
Selection and segregation distortion in a sex-differentiated population.

We extend the classical model for selection at an autosomal locus in a sex-differentiated population to include segregation distortion. The equations remain the same, but the fitness parameters are interpreted differently and refer to alleles instead of genotypes. We derive conditions for internal and external stability of the equilibria, i.e., stability with respect to perturbations of alleles that are already present at equilibrium and stability with respect to invasion attempts by newly arising alleles. We show that, in a sex-differentiated population, external stability of an equilibrium can be judged on the basis of Shaw--Mohler criteria. Throughout, we compare the situation in populations with and without sex differentiation. Interestingly, internal stability is more difficult to achieve in a population without sex differentiation than in a population in which selection and segregation distortion are restricted to one sex. In a companion paper we show how the general results of the present paper can lead to new insights into specific systems such as the t complex of the house mouse.
Clinical and Serological Features of Patients Referred through a Rheumatology Triage System because of Positive Antinuclear Antibodies

Background The referral of patients with positive anti-nuclear antibody (ANA) tests has been criticized as an inappropriate use of medical resources. The utility of a positive ANA test in a central triage (CT) system was studied by determining the autoantibody profiles and clinical diagnoses of patients referred to rheumatologists through a CT system because of a positive ANA test. Methods Patients that met three criteria were included: (1) referred to Rheumatology CT over a three year interval; (2) reason for referral was a “positive ANA”; (3) were evaluated by a certified rheumatologist. The CT clinical database was used to obtain demographic and clinical information and a serological database was used to retrieve specific ANA and/or extractable nuclear antigen (ENA) test results. Clinical information was extracted from the consulting rheumatologist's report. Results 15,357 patients were referred through the CT system; 643 (4.1%) of these because of a positive ANA and of these 263 (40.9%) were evaluated by a certified rheumatologist. In 63/263 (24%) of ANA positive patients, the specialist provided a diagnosis of an ANA associated rheumatic disease (AARD) while 69 (26.2%) had no evidence of any disease; 102 (38.8%) had other rheumatologic diagnoses and 29 (11%) had conditions that did not meet AARD classification criteria. Of ANA positive archived sera, 15.1% were anti-DFS70 positive and 91.2% of these did not have an AARD. Conclusions This is the first study to evaluate the serological and clinical features of patients referred through a CT system because of a positive ANA. The spectrum of autoantibody specificities was wide with anti-Ro52/TRIM21 being the most common autoantibody detected. Approximately 15% of referrals had only antibodies to DFS70, the vast majority of which did not have clinical evidence for an AARD. These findings provide insight into the utility of autoantibody testing in a CT system.
Mitigating artifacts in back-projection source imaging with implications for frequency-dependent properties of the Tohoku-Oki earthquake

Comparing teleseismic array back-projection source images of the 2011 Tohoku-Oki earthquake with results from static and kinematic finite source inversions has revealed little overlap between the regions of high- and low-frequency slip. Motivated by this interesting observation, back-projection studies extended to intermediate frequencies, down to about 0.1 Hz, have suggested that a progressive transition of rupture properties as a function of frequency is observable. Here, by adapting the concept of array response function to non-stationary signals, we demonstrate that the “swimming artifact”, a systematic drift resulting from signal non-stationarity, induces significant bias on beamforming back-projection at low frequencies. We introduce a “reference window strategy” into the multitaper-MUSIC back-projection technique and significantly mitigate the “swimming artifact” at high frequencies (1 s to 4 s). At lower frequencies, this modification yields notable, but significantly smaller, artifacts than time-domain stacking. We perform extensive synthetic tests that include a 3D regional velocity model for Japan. We analyze the recordings of the Tohoku-Oki earthquake at the USArray and at the European array at periods from 1 s to 16 s. The migration of the source location as a function of period, regardless of the back-projection methods, has characteristics that are consistent with the expected effect of the “swimming artifact”. In particular, the apparent up-dip migration as a function of frequency obtained with the USArray can be explained by the “swimming artifact”. This indicates that the most substantial frequency-dependence of the Tohoku-Oki earthquake source occurs at periods longer than 16 s. Thus, low-frequency back-projection needs to be further tested and validated in order to contribute to the characterization of frequency-dependent rupture properties.
Cortical Button Fixation

Background: Patellar tendon ruptures require surgical repair to optimize outcomes, but no consensus exists regarding the ideal repair technique. Cortical button fixation is a secure method for tendon repair that has not been studied in patellar tendons. Hypothesis: Cortical button repair is biomechanically superior to the standard transpatellar repair and biomechanically equivalent to suture anchor repair. Study Design: Controlled laboratory study. Methods: Twenty-three fresh-frozen cadaveric knees were used to compare 3 techniques of patellar tendon repair after a simulated rupture at the inferior pole of the patella. Repairs were performed at 45° of flexion using a standard transpatellar suture repair (n = 7), polyetheretherketone (PEEK) suture anchor repair (n = 8), or cortical button repair (n = 8). All specimens were tested on a custom apparatus to simulate cyclic open kinetic chain quadriceps contraction from extension to 90o of flexion. Outcomes of gap formation up to 250 cycles, maximum load to failure, and mode of failure were evaluated. Results: Cortical button repair had significantly less gap formation than anchor repair after 1 cycle (P < .001) and 20 cycles (P < .01) and significantly less gap formation than suture repair from 1 to 250 cycles (P < .05). Cortical button repair sustained significantly higher loads to failure than anchor repair and suture repair (P < .001). All suture repairs failed through the suture. Anchor repairs failed at the suture-anchor eyelet interface (n = 4) or by anchor pullout (n = 3). Cortical button repairs either failed through the suture (n = 5), secondary failure of the patellar tendon (n = 2), or subsidence of the button through the anterior cortex of the patella (n = 1). Conclusion: Patellar tendon repair using cortical button fixation demonstrated mechanical advantages over suture repair and anchor repair in cadaveric specimens. Cortical button fixation showed less cyclic gap formation and withstood at least twice the load to failure of the construct. Clinical Relevance: The biomechanical superiority of cortical button fixation may impart clinical advantages in accelerating postoperative rehabilitation.
Intrahousehold allocation and gender relations

The paper reviews recent theory and empirical evidence testing unitary versus collective models of the household. In contrast to the unitary model, the collective model posits that individuals within households have different preferences and do not pool their income. Moreover, the collective model predicts that intrahousehold allocations reflect differences in preferences and "bargaining power" of individuals within the household. Using new household data sets from Bangladesh, Indonesia, Ethiopia, and South Africa, we present measures of individual characteristics that are highly correlated with bargaining power, namely human capital and in ividually-controlled assets, evaluated at the time of marriage. In all country case studies we reject the unitary model as a description of household behavior, but to different degrees. Results suggest that assets controlled by women have a positive and significant effect on expenditure allocations toward the next generation, such as education and children's clothing. We also examine individual-level education outcomes and find that parents do not have identical preferences toward sons and daughters within or across countries.
Akt- and Erk-mediated regulation of proliferation and differentiation during PDGFRβ-induced MSC self-renewal

Understanding the mechanisms that direct mesenchymal stem cell (MSC) self‐renewal fate decisions is a key to most tissue regenerative approaches. The aim of this study here was to investigate the mechanisms of action of platelet‐derived growth factor receptor β (PDGFRβ) signalling on MSC proliferation and differentiation. MSC were cultured and stimulated with PDGF‐BB together with inhibitors of second messenger pathways. Cell proliferation was assessed using ethynyl‐2′‐deoxyuridine and phosphorylation status of signalling molecules assessed by Western Blots. To assess differentiation potentials, cells were transferred to adipogenic or osteogenic media, and differentiation assessed by expression of differentiation association genes by qRT‐PCR, and by long‐term culture assays. Our results showed that distinct pathways with opposing actions were activated by PDGF. PI3K/Akt signalling was the main contributor to MSC proliferation in response to activation of PDGFRβ. We also demonstrate a negative feedback mechanism between PI3K/Akt and PDGFR‐β expression. In addition, PI3K/Akt downstream signal cascades, mTOR and its associated proteins p70S6K and 4E‐BP1 were involved. These pathways induced the expression of cyclin D1, cyclin D3 and CDK6 to promote cell cycle progression and MSC proliferation. In contrast, activation of Erk by PDGFRβ signalling potently inhibited the adipocytic differentiation of MSCs by blocking PPARγ and CEBPα expression. The data suggest that PDGFRβ‐induced Akt and Erk pathways regulate opposing fate decisions of proliferation and differentiation to promote MSC self‐renewal. Thus, activation of multiple intracellular cascades is required for successful and sustainable MSC self‐renewal strategies.
Proximal Analysis and the Minimal Time Function

Under general hypotheses on the target set S and the dynamics of the system, we show that the minimal time function TS(\cdot) is a proximal solution to the Hamilton--Jacobi equation. Uniqueness results are obtained with two different kinds of boundary conditions. A new propagation result is proven, and as an application, we give necessary and sufficient conditions for TS(\cdot) to be Lipschitz continuous near S. A Petrov-type modulus condition is also shown to be sufficient for continuity of TS(\cdot) near S.
New High-Affinity Monoclonal Antibodies against Shiga Toxin 1 Facilitate the Detection of Hybrid Stx1/Stx2 In Vivo

Background Shiga toxin-producing E. coli (STEC) are a group of common and potentially deadly intestinal pathogens expressing Shiga toxin (Stx) as a primary virulence factor. Of the two types of Stx, Stx2 is responsible for more severe symptoms during infection, while Stx1 is almost identical to the Shiga toxin from Shigella dysenteriae, a ubiquitous pathogen in developing countries. Although antibodies against Stx1 have been reported, few have reached the affinity needed for assembling highly sensitive immunoassays. Sensitive and affordable immunoassays for Stx1 and Stx2 could help improve detection of STEC in livestock, food, the environment, and in clinical samples resulting in improved food safety and human health. Method and Findings Three new monoclonal antibodies (mAbs) against the B subunit of Stx1 were generated using recombinant toxoid Stx1E167Q and hybridoma technology. These new mAbs recognize all subtypes of Stx1, but do not cross-react with any subtype of Stx2. In addition, they exhibited the ability to neutralize Stx1 toxicity in Vero cell assays. An optimized sandwich ELISA using of a pair of these mAbs had a limit of detection of 8.7 pg/mL, which is superior to any existing assay of this kind. Using one of these Stx1 mAbs in concert with Stx2 mAbs, the presence of hybrid Stx1/Stx2 toxin in the culture media of STEC strains that express both Stx1 and Stx2 was demonstrated. Conclusions These new mAbs provide a mix of availability, utility, versatility, and most importantly, increased sensitivity for detection of Stx1. There are numerous potential applications for these mAbs, including low-cost detection assays and therapeutic use. Analysis of hybrid Stx1/2 could provide new insights on the structure, activity, and cellular targets of Shiga toxins.
Poincaré Series of Quantum Spaces Associated to Hecke Operators

We study the Poincar\'e series of the quantum spaces associated to a Hecke operator, i.e., a Yang-Baxter operator satisfying the equation $(x+1)(x-q)=0$. The Poincar\'e series of the corresponding matrix bialgebra is also considered. Using an old result on Poly\'a frequency sequence, we show that the Poincar\'e series of quantum spaces are always rational functions having negative roots and positive poles. In particular, we show that the rank of an even Hecke operator should be rational functions having negative roots and positive poles. In particular, we show that the rank of an even Hecke operator should be greater than the dimension of the vector space it is acting on.
Linear Beamforming for Multiuser MIMO Downlink Systems with Channel Orthogonalization

Recently linear processing strategies have been developed to approach the optimum performance of dirty paper coding with low complexity in multiuser multiple-input multiple-output (MIMO) downlink systems. In this paper, we propose a new linear coordinated beamforming algorithm which is applicable to the systems with an arbitrary number of antennas and users. Unlike other conventional methods, our scheme exploits the orthogonalized effective channels to yield the transmit beamforming and receive combining vectors. As the proposed scheme generates a solution in a non-iterative fashion, it is more feasible than other iterative schemes. Simulation results show that the performance of our proposed scheme is very close to the conventional iterative scheme with significantly reduced complexity. For a system equipped with four transmit and four receive antennas with two users, the proposed scheme exhibits the bit error rate (BER) comparable to the conventional scheme with a complexity reduction of 79%.
Exploring the potential of schemes in building NLP tools for arabic language

Arabic is known for its sparseness, which explains the difficulty of its automatic processing. The arabic language is b ased on schemes; lemmas are produced using derivation based on roots and schemes. This latter character presents two major advantages: First, this "hidden side" of the arabic language composed of schemes suffers much less from sparseness since it represents a finite set, second, schemes keep a large number of features of the language in a much reduced vocabulary size. Schemes present a very great perspective and have great potential in building accurate natural language processing tools for arabic. In this work we tried to explore this potential by building some NLP tools while relying entirely on schemes. The work is related to text classification and a Probabilistic Context Free Grammar (PCFG) parsing.
A Generic Method for Stamp Segmentation Using Part-Based Features

Traditionally, stamps are considered as a seal of authenticity for documents. For automatic processing and verification, segmentation of stamps from documents is pivotal. Existing methods for stamp extraction mostly employ color and/or shape based techniques, thereby limiting their applicability to only colored and specific shape stamps. In this paper, a novel, generic method based on part-based features is presented for segmentation of stamps from document images. The proposed method can segment black, colored, unseen, arbitrary shaped, textual, as well as graphical stamps. The proposed method is evaluated on a publicly available dataset for stamp detection and verification and achieved recall and precision of 73% and 83% respectively, for black stamps which were not addressed in the past.
1 SUSTAINABLE TOURISM : A CRITICAL ANALYSIS

Research report series Delivering strategic knowledge to enhance the environmental, economic and social sustainability of tourism. The primary aim of CRC Tourism's research report series is technology transfer. The reports are targeted toward both industry and government users and tourism researchers. The content of this technical report series primarily focuses on applications, but may also advance research methodology and tourism theory. The report series titles relate to CRC Tourism's research program areas. All research reports are peer reviewed by at least two external reviewers. All rights reserved. No parts of this report may be reproduced, stored in a retrieval system or transmitted in any form or by means of electronic, mechanical, photocopying, recording or otherwise without the prior permission of the publisher. Any inquiries should be directed to CRC for Sustainable Tourism. 1 contents 6 Executive summary 8 Introduction 9 1 ~ Sustainable development 13 2 ~ Evolution of sustainable tourism Graduations of sustainability Sustainable development interpretations Advocacy platform Cautionary platform Adaptancy platform Knowledge-based platform Emergency of sustainability as a dominant tourism paradigm A broad context model of sustainability-related tourism scenarios 20 3 ~ Sustainability indicators Sustainable tourism indicator categories Candidate sustainable tourism indicators Sample procedure for implementing ST 25 4 ~ Problems and issues in sustainable tourism Defining the goals of ST Establishing an appropriate planning and management framework Selecting, measuring and monitoring appropriate indicators Assessing indicator performance and determining achievement of goals Implementing remedial action 32 5 ~ Indications of sustainability 37 Conclusions 38 References 43 Authors Protected areas Small islands Rural and indigenous areas Mass tourism A synopsis of mass tourism and alternative tourism sustainability
Forty-eight weeks treatment with clevudine 30 mg qd versus lamivudine 100 mg qd for chronic hepatitis B infection: a double-blind randomized study

Background/Aims Clevudine is a pyrimidine analogue with potent activity against hepatitis B virus (HBV) replication in vitro. In a previous pivotal phase III clinical study, 24 weeks treatment with clevudine 30 mg has been shown to profoundly suppress HBV replication and normalize serum alanine aminotransferase level. Methods In this study, we compare the efficacy and safety of clevudine (30 mg daily) versus lamivudine (100 mg daily) for 48 weeks in treatment-naive chronic hepatitis B e antigen (HBeAg) positive patients. Results Ninety-two chronic HBeAg positive patients were randomized to receive clevudine 30 mg daily or lamivudine 100 mg daily in a 1:1 ratio. The clevudine group demonstrated greater viral suppression at week 48 when compared with the lamivudine group (median reduction: 4.27 vs. 3.17 log10 copies/ml at week 48, p<0.0001). At week 48, serum HBV DNA level was below 300 copies/mL in 73% and 40% in the clevudine and lamivudine groups, respectively (p=0.001). HBeAg seroconversion occurred in 18% of patients in the clevudine group versus 12% in the lamivudine group at week 48. Lamivudine-resistant mutations were detected in 11 (24%) patients in the lamivudine group, who showed viral rebound during lamivudine therapy but no resistance was found in the clevudine group during 48-week treatment period. Conclusions A 48-week dosing with clevudine 30 mg daily was superior to lamivudine 100 mg daily in suppressing HBV replication, with no emergence of viral breakthrough in patients with HBeAg positive chronic hepatits B.