Miracle-dz/UniFAR-FTUs huggingface dataset:
Simulating quantum computers with probabilistic methods

We investigate the boundary between classical and quantum computational power. This work consists of two parts. First we develop new classical simulation algorithms that are centered on sampling methods. Using these techniques we generate new classes of classically simulatable quantum circuits where standard techniques relying on the exact computation of measurement probabilities fail to provide efficient simulations. For example, we show how various concatenations of matchgate, Toffoli, Clifford, bounded-depth, Fourier transform and other circuits are classically simulatable. We also prove that sparse quantum circuits as well as circuits composed of CNOT and exp[itheta;X] gates can be simulated classically. In a second part, we apply our results to the simulation of quantum algorithms. It is shown that a recent quantum algorithm, concerned with the estimation of Potts model partition functions, can be simulated efficiently classically. Finally, we show that the exponential speed-ups of Simon's and Shor's algorithms crucially depend on the very last stage in these algorithms, dealing with the classical postprocessing of the measurement outcomes. Specifically, we prove that both algorithms would be classically simulatable if the function classically computed in this step had a sufficiently peaked Fourier spectrum.
HDAC1 Inactivation Induces Mitotic Defect and Caspase-Independent Autophagic Cell Death in Liver Cancer

Histone deacetylases (HDACs) are known to play a central role in the regulation of several cellular properties interlinked with the development and progression of cancer. Recently, HDAC1 has been reported to be overexpressed in hepatocellular carcinoma (HCC), but its biological roles in hepatocarcinogenesis remain to be elucidated. In this study, we demonstrated overexpression of HDAC1 in a subset of human HCCs and liver cancer cell lines. HDAC1 inactivation resulted in regression of tumor cell growth and activation of caspase-independent autophagic cell death, via LC3B-II activation pathway in Hep3B cells. In cell cycle regulation, HDAC1 inactivation selectively induced both p21WAF1/Cip1 and p27Kip1 expressions, and simultaneously suppressed the expression of cyclin D1 and CDK2. Consequently, HDAC1 inactivation led to the hypophosphorylation of pRb in G1/S transition, and thereby inactivated E2F/DP1 transcription activity. In addition, we demonstrated that HDAC1 suppresses p21WAF1/Cip1 transcriptional activity through Sp1-binding sites in the p21WAF1/Cip1 promoter. Furthermore, sustained suppression of HDAC1 attenuated in vitro colony formation and in vivo tumor growth in a mouse xenograft model. Taken together, we suggest the aberrant regulation of HDAC1 in HCC and its epigenetic regulation of gene transcription of autophagy and cell cycle components. Overexpression of HDAC1 may play a pivotal role through the systemic regulation of mitotic effectors in the development of HCC, providing a particularly relevant potential target in cancer therapy.
Influenza virus hemagglutinin and neuraminidase cytoplasmic tails control particle shape

The cytoplasmic tails of the influenza virus glycoproteins hemagglutinin (HA) and neuraminidase (NA) are highly conserved in sequence for all virus subtypes and it is believed that assembly of this enveloped virus depends on interactions of these domains with cytoplasmic viral components. However, it is possible to rescue altered influenza viruses lacking either the HA or NA cytoplasmic tails. We have obtained an influenza virus that lacks both the cytoplasmic tail of HA and NA. Particle production is reduced ∼10‐fold but these particles, although having a fairly normal protein composition, are greatly elongated and of extended irregular shape. We propose a model in which the interactions of the cytoplasmic tails of HA and NA with an internal viral component are so important for spherical virion shape that there is dual redundancy in the interactions.
The Rising Cost of Flood Insurance in New York City

To understand the dimensions of this problem, the New York City Mayor’s Office of Long-Term Planning and Sustainability asked the RAND Corporation to analyze the changes in the flood insurance landscape in New York City following Hurricane Sandy and what these changes will mean to the City’s residents and businesses. The new report, Flood Insurance in New York City Following Hurricane Sandy (2013), provides the mostcomprehensive answers to date to several important questions:
How do we think machines think? An fMRI study of alleged competition with an artificial intelligence

Mentalizing is defined as the inference of mental states of fellow humans, and is a particularly important skill for social interactions. Here we assessed whether activity in brain areas involved in mentalizing is specific to the processing of mental states or can be generalized to the inference of non-mental states by comparing brain responses during the interaction with an intentional and an artificial agent. Participants were scanned using fMRI during interactive rock-paper-scissors games while believing their opponent was a fellow human (Intentional agent, Int), a humanoid robot endowed with an artificial intelligence (Artificial agent, Art), or a computer playing randomly (Random agent, Rnd). Participants' subjective reports indicated that they adopted different stances against the three agents. The contrast of brain activity during interaction with the artificial and the random agents didn't yield any cluster at the threshold used, suggesting the absence of a reproducible stance when interacting with an artificial intelligence. We probed response to the artificial agent in regions of interest corresponding to clusters found in the contrast between the intentional and the random agents. In the precuneus involved in working memory, the posterior intraparietal suclus, in the control of attention and the dorsolateral prefrontal cortex, in executive functions, brain activity for Art was larger than for Rnd but lower than for Int, supporting the intrinsically engaging nature of social interactions. A similar pattern in the left premotor cortex and anterior intraparietal sulcus involved in motor resonance suggested that participants simulated human, and to a lesser extend humanoid robot actions, when playing the game. Finally, mentalizing regions, the medial prefrontal cortex and right temporoparietal junction, responded to the human only, supporting the specificity of mentalizing areas for interactions with intentional agents.
The Effectiveness of Demand-Side Government Intervention to Promote Elderly Employment: Evidence from Japan

In this article, the authors examine the effect of a demand-side government intervention on employment of the elderly. The growing gap between the increasing pension eligibility age and the mandatory retirement age has emerged as a serious social concern in Japan. Starting in 2006, the government legally mandated employers to offer continuous employment up to the increased pension eligibility age. By comparing cohorts affected and unaffected by the policy, the authors find that such legal enforcement increases the employment rate of men in their early 60s. Furthermore, the effect is concentrated on employees at large-sized firms, where mandatory retirement was applied more strictly in the past. The authors then examine potential complementarity between pension reform—the conventional supply-side intervention—and the demand-side intervention. Evidence suggests that the impact of an increase in pension eligibility age on elderly employment is slightly larger when combined with legal demand-side enforcement.
Factors that enhance academic learning and study behaviours: A qualitative study

This exploratory study examined students’ conceptions of factors that enhance the use and application of academic learning and study strategies (LSS). A qualitative approach was used to explore the conceptions of 23 first-year university students (female = 14; age range = 18–24 years). Data were collected using unstructured interviews and narrative sketches. Thematic analysis revealed three themes; namely clarity, emotional intelligence, and life circumstances. LSS clarity showed that knowledge of the self as a learner and well-defined educational goals can enhance engagement in the academic study process. Emotional intelligence as LSS referred to the importance of self-management and emotional regulation; while life circumstances in LSS emphasised the impact of real world challenges that affect the learning process. Student development counselling for LSS should consider the extent to which students have a sense of clarity, emotional intelligence, and life orientation important for their education success.
MULTICOAX : A SOFTWARE TOOL FOR PREDICTING MULTIPACTOR RF BREAKDOWN THRESHOLD IN COAXIAL AND CIRCULAR WAVEGUIDES

In the last years many numerical techniques and CAD tools have been developed in order to characterize the electromagnetic response of microwave devices such as filters or resonators. On the other hand, today applications also demand a higher component integration as well as more power hadling capabilities. Both requeriments lead to higher electromagnetic field densities inside the devices which results in a higher risk from the microwave breakdown point of view.
Helicobacter pylori Infection with Atrophic Gastritis Is an Independent Risk Factor for Advanced Colonic Neoplasm

Background/Aims Helicobacter pylori is a major risk factor for atrophic gastritis (AG) and gastric cancer. The correlation between H. pylori, AG and colorectal neoplasm (CRN) has only been examined in a limited number of studies, and findings have been inconclusive. We aimed to investigate the association between H. pylori infection status, AG and advanced CRN. Methods This cross-sectional study investigated the relationship between the presence of serum anti-H. pylori IgG antibodies, AG, and advanced CRN in 6,351 consecutive asymptomatic subjects who underwent a screening colonoscopy. Results A total of 316 participants (5.0%) had advanced CRN. H. pylori seropositivity was 61.3%. In a univariate analysis, the presence of H. pylori infection was associated with advanced CRN (odds ratio [OR], 1.49; 95% confidence interval [CI], 1.17 to 1.91; p=0.001). H. pylori infection was associated with an increased risk of advanced CRN after adjusting for clinically relevant confounders (OR, 1.34; 95% CI, 1.04 to 1.72; p=0.023). H. pylori-related AG was significantly associated with the risk of advanced CRN (OR, 1.40; 95% CI, 1.03 to 1.91; p=0.030), whereas H. pylori infection without AG was not. Conclusions H. pylori infection increased the risk of advanced CRN, especially when it was combined with AG. Strict colonoscopy screening and surveillance may be warranted in those with H. pylori-positive AG.
Optimal Insurance for a Minimal Expected Retention: The Case of an Ambiguity-Seeking Insurer

In the classical expected utility framework, a problem of optimal insurance design with a premium constraint is equivalent to a problem of optimal insurance design with a minimum expected retention constraint. When the insurer has ambiguous beliefs represented by a non-additive probability measure, as in Schmeidler, this equivalence no longer holds. Recently, Amarante, Ghossoub and Phelps examined the problem of optimal insurance design with a premium constraint when the insurer has ambiguous beliefs. In particular, they showed that when the insurer is ambiguity-seeking, with a concave distortion of the insured’s probability measure, then the optimal indemnity schedule is a state-contingent deductible schedule, in which the deductible depends on the state of the world only through the insurer’s distortion function. In this paper, we examine the problem of optimal insurance design with a minimum expected retention constraint, in the case where the insurer is ambiguity-seeking. We obtain the aforementioned result of Amarante, Ghossoub and Phelps and the classical result of Arrow as special cases.
Aging Reveals a Role for Nigral Tyrosine Hydroxylase ser31 Phosphorylation in Locomotor Activity Generation

Background Tyrosine hydroxylase (TH) regulates dopamine (DA) bioavailability. Its product, L-DOPA, is an established treatment for Parkinson's disease (PD), suggesting that TH regulation influences locomotion. Site-specific phosphorylation of TH at ser31 and ser40 regulates activity. No direct evidence shows that ser40 phosphorylation is the dominating mechanism of regulating TH activity in vivo, and physiologically-relevant stimuli increase L-DOPA biosynthesis independent of ser40 phosphorylation. Significant loss of locomotor activity occurs in aging as in PD, despite less loss of striatal DA or TH in aging compared to the loss associated with symptomatic PD. However, in the substantia nigra (SN), there is equivalent loss of DA or TH in aging and at the onset of PD symptoms. Growth factors increase locomotor activity in both PD and aging models and increase DA bioavailability and ser31 TH phosphorylation in SN, suggesting that ser31 TH phosphorylation status in the SN, not striatum, regulates DA bioavailability necessary for locomotor activity. Methodology and Principal Findings We longitudinally characterized locomotor activity in young and older Brown-Norway Fischer 344 F1 hybrid rats (18 months apart in age) at two time periods, eight months apart. The aged group served as an intact and pharmacologically-naïve source of deficient locomotor activity. Following locomotor testing, we analyzed DA tissue content, TH protein, and TH phosphorylation in striatum, SN, nucleus accumbens, and VTA. Levels of TH protein combined with ser31 phosphorylation alone reflected inherent differences in DA levels among the four regions. Measures strictly pertaining to locomotor activity initiation significantly correlated to DA content only in the SN. Nigral TH protein and ser31 phosphorylation together significantly correlated to test subject's maximum movement number, horizontal activity, and duration. Conclusions/Significance Together, these results show ser31 TH phosphorylation regulates DA bioavailability in intact neuropil, its status in the SN may regulate locomotor activity generation, and it may represent an accurate target for treating locomotor deficiency. They also show that neurotransmitter regulation in cell body regions can mediate behavioral outcomes and that ser31 TH phosphorylation plays a role in behaviors dependent upon catecholamines, such as dopamine.
A study of the microbial community at the interface between granite bedrock and soil using a culture-independent and culture-dependent approach

The dissolution of minerals plays an important role in the formation of soils and sediments. In nutrient limiting soils, minerals constitute a major reservoir of bio-essential cations. Of particular interest is granite as it is the major rock type of the continental land mass. Although certain bacteria have been shown to enhance weathering of granite-forming minerals, little is known about the dissolution of granite, at the whole rock scale, and the microbial community involved. In this study, both culture-independent and culture-dependent approaches were used to study the bacterial community at the interface between granite bedrock and nutrient limiting soil in Dartmoor National Park, United Kingdom. High throughput sequencing demonstrated that over 70% of the bacterial population consisted of the bacterial classes Bacilli, Beta-proteobacteria and Gamma-proteo-bacteria. Bacteria belonging to the genera Serratia, Pseudomonas, Bacillus, Paenibacillus, Chromo-bacterium and Burkholderia were isolated from the sample site. All of the isolates were able to grow in a minimal growth medium, which contained glucose and ammonium chloride, with granite as the sole source of bio-essential elements. Sixty six percent of the isolates significantly enhanced basalt dissolution (p < 0.05). Dissolution of Si, K, Ca and Mg correlated with production of oxalic acid and acidification. The results of this study suggest that microorganisms in nutrient limiting soils can enhance the rate of granite dissolution, which is an important part of the biogeochemical cycle.
Polyneuropathy in critically ill patients

Five patients developed a severe motor and sensory polyneuropathy at the peak of critical illness (sepsis and multiorgan dysfunction complicating a variety of primary illnesses). Difficulties in weaning from the ventilator as the critical illness subsided and the development of flaccid and areflexic limbs were early clinical signs. However, electrophysiological studies, especially needle electrode examination of skeletal muscle, provided the definite evidence of polyneuropathy. The cause is uncertain, but the electrophysiological and morphological features indicate a primary axonal polyneuropathy with sparing of the central nervous system. Nutritional factors may have played a role, since the polyneuropathy improved in all five patients after total parenteral nutrition had been started, including the three patients who later died of unrelated causes. The features allow diagnosis during life, and encourage continued intensive management since recovery from the polyneuropathy may occur.
Reflections on reflexions – II. Effects of light echoes on the luminosity and spectra of Type Ia supernovae

In this paper, we present and discuss the effects of scattered light echoes (LEs) on the luminosity and spectral appearance of Type Ia supernovae (SNe). After introducing the basic concept of LE spectral synthesis by means of LE models and real observations, we investigate the deviations from pure SN spectra, light and colour curves, the signatures that witness the presence of an LE and the possible inferences on the extinction law. The effects on the photometric parameters and spectral features are also discussed. In particular, for the case of circumstellar dust, LEs are found to introduce an apparent relation between the post-maximum decline rate and the absolute luminosity, which is most likely going to affect the well-known Pskowski-Phillips relation.
Building an Ontology of Cyber Security

—Situation awareness depends on a reliable perception of the environment and comprehension of its semantic structures. In this respect, cyberspace presents a unique challenge to the situation awareness of users and analysts, since it is a unique combination of human and machine elements, whose complex interactions occur in a global communication network. Accordingly, we outline the underpinnings of an ontology of secure operations in cyberspace, presenting the ontology framework and providing two modeling examples. We make the case for adopting a rigorous semantic model of cyber security to overcome the current limits of the state of the art.
Can Analysts Really Forecast? Evidence from Karachi Stock Exchange

This study examines the impact of analysts’ recommendations on stock prices listed on the Karachi Stock Exchange for the period 2006–12. The recommendations are extracted from the daily Morning Shout report published by Khadim Ali Shah Bukhari Securities Ltd (KASB), which provides buy and sell recommendations for different stocks. We use the market model to estimate the abnormal returns around the recommendation dates for these securities. The study also investigates whether the abnormal returns are due to price pressure or information content. We find that investors earn abnormal returns on the basis of analysts’ recommendations for these securities. The results are robust in considering only the sub-sample subsequent to 2008’s global financial crisis, and are also consistent with the information content hypothesis and price pressure hypothesis.
Elastic complex event processing exploiting prediction

Supporting real-time, cost-effective execution of Complex Event processing applications in the cloud has been an important goal for many scientists in recent years. Distributed Stream Processing Systems (DSPS) have been widely adopted by major computing companies as a powerful approach for large-scale Complex Event processing (CEP). However, determining the appropriate degree of parallelism of the DSPS' components can be particularly challenging as the volume of data streams is becoming increasingly large, the rule set is becoming continuously complex, and the system must be able to handle such large data stream volumes in real-time, taking into consideration changes in the burstiness levels and data characteristics. In this paper we describe our solution to building elastic complex event processing systems on top of our distributed CEP system which combines two commonly used frameworks, Storm and Esper, in order to provide both ease of usage and scalability. Our approach makes the following contributions: (i) we provide a mechanism for predicting the load and latency of the Esper engines in upcoming time windows, and (ii) we propose a novel algorithm for automatically adjusting the number of engines to use in the upcoming windows, taking into account the cost and the performance gains of possible changes. Our detailed experimental evaluation with a real traffic monitoring application that analyzes bus traces from the city of Dublin indicates the benefits in the working of our approach. Our proposal outperforms the current state of the art technique in regards to the amount of tuples that it can process by four orders of magnitude.
An analysis of the nature of the Governance of International Schools and the potential for securing appropriate governance

The aim of this enquiry was to ‘analyse the nature of the governance of international schools and the potential of accreditation for securing appropriate governance’. The research questions were: ‘What is the nature of the governance of international schools as experienced by heads of international schools? ’ ‘What is the nature of the governance of international schools as experienced by representatives of organizations that accredit international schools, and the owners of international schools? ’ and ‘What is the potential of accreditation for securing appropriate governance of international schools? ’. The relevant literature was reviewed. Empirical data were collected by means of a questionnaire-based survey of heads, and interviews with: executives from accreditation organizations, representatives of owned schools and heads. A framework for the analysis of the data was developed, which employed two analytic distinctions: the ‘ownership’ of schools, and potential of a financial profit impetus. The main findings are as follows. The governance of international schools is not static, and successful governance is dependent upon the type of school and board structure. Boards tend not to receive proper and on-going training and many of the models of governance in use have inherent weaknesses, which require a more robust system of oversight. Governance structures and practice have not been able to keep pace with the increasing complexity of types of international schools. The organisations that accredit international schools, including their governance, have been unable to deal with the monitoring and enforcement standards of governance. Despite an inability of accreditation organisations to monitor and enforce standards of governance, they should take up this responsibility. To achieve this potential, a multi-faceted approach is necessary. Accreditation organizations need to gain further understandings of the governing of ‘owned schools’. Common guidelines and standards for governance will be required.