Miracle-dz/UniFAR-FTUs huggingface dataset:
An Efficient Directed Localization Recursion Protocol for Wireless Sensor Networks

The establishment of a localization system is an important task in wireless sensor networks. Due to the geographical correlation between sensed data, location information is commonly used to name the gathered data and address nodes and regions in data dissemination protocols. In general, to estimate its location, a node needs the position information of at least three reference points (neighbors that know their positions). In this work, we propose a different scheme in which only two reference points are required in order to estimate a position. To choose between the two possible solutions of an estimate, we use the known direction of the recursion. This approach leads to a recursive localization system that works with low-density networks (increasing by 40 percent the number of nodes with estimates in some cases), reduces the position error by almost 30 percent, requires 37 percent less processor resources to estimate a position, uses fewer beacon nodes, and also indicates the node position error based on its distance to the recursion origin. No GPS-enabled node is required, since the recursion origin can be used as a relative coordinate system. The algorithm's evaluation is performed by comparing it with a similar localization system; also, experiments are made to evaluate the impact of both systems in geographic algorithms.
Social ties and susceptibility to the common cold.

OBJECTIVE To examine the hypothesis that diverse ties to friends, family, work, and community are associated with increased host resistance to infection. DESIGN After reporting the extent of participation in 12 types of social ties (eg, spouse, parent, friend, workmate, member of social group), subjects were given nasal drops containing 1 of 2 rhinoviruses and monitored for the development of a common cold. SETTING Quarantine. PARTICIPANTS A total of 276 healthy volunteers, aged 18 to 55 years, neither seropositive for human immunodeficiency virus nor pregnant. OUTCOME MEASURES Colds (illness in the presence of a verified infection), mucus production, mucociliary clearance function, and amount of viral replication. RESULTS In response to both viruses, those with more types of social ties were less susceptible to common colds, produced less mucus, were more effective in ciliary clearance of their nasal passages, and shed less virus. These relationships were unaltered by statistical controls for prechallenge virus-specific antibody, virus type, age, sex, season, body mass index, education, and race. Susceptibility to colds decreased in a dose-response manner with increased diversity of the social network. There was an adjusted relative risk of 4.2 comparing persons with fewest (1 to 3) to those with most (6 or more) types of social ties. Although smoking, poor sleep quality, alcohol abstinence, low dietary intake of vitamin C, elevated catecholamine levels, and being introverted were all associated with greater susceptibility to colds, they could only partially account for the relation between social network diversity and incidence of colds. CONCLUSIONS More diverse social networks were associated with greater resistance to upper respiratory illness.
Ketogenic Diet in Neuromuscular and Neurodegenerative Diseases

An increasing number of data demonstrate the utility of ketogenic diets in a variety of metabolic diseases as obesity, metabolic syndrome, and diabetes. In regard to neurological disorders, ketogenic diet is recognized as an effective treatment for pharmacoresistant epilepsy but emerging data suggests that ketogenic diet could be also useful in amyotrophic lateral sclerosis, Alzheimer, Parkinson's disease, and some mitochondriopathies. Although these diseases have different pathogenesis and features, there are some common mechanisms that could explain the effects of ketogenic diets. These mechanisms are to provide an efficient source of energy for the treatment of certain types of neurodegenerative diseases characterized by focal brain hypometabolism; to decrease the oxidative damage associated with various kinds of metabolic stress; to increase the mitochondrial biogenesis pathways; and to take advantage of the capacity of ketones to bypass the defect in complex I activity implicated in some neurological diseases. These mechanisms will be discussed in this review.
Operational assessment and adaptive selection of micro-Doppler features

A key challenge for radar surveillance systems is the discrimination of ground-based targets, especially humans from animals, as well as different types of human activities. For this purpose, target micro-Doppler signatures have been shown to yield high automatic target classification rates; however, performance is typically only given for near-optimal operating conditions using a fixed set of features. Over the past few decades dozens of micro-Doppler features have been proposed, when in fact utilisation of all possible features does not guarantee the maximum classification performance and the selection of an optimal subset of features is scenario dependent. In this work, a comprehensive survey of micro-Doppler features and their dependence upon system parameters and operational conditions – such as transmit frequency, range and Doppler resolution, antenna–target geometry, signal-to-noise ratio, and dwell time – is given. Algorithms for optimising classification performance for a reduced number of features are presented. Performance gains achievable using adaptive feature selection are assessed for a case study of interest.
An Integrated Expression Profiling Reveals Target Genes of TGF-β and TNF-α Possibly Mediated by MicroRNAs in Lung Cancer Cells

EMT (epithelial-mesenchymal transition) is crucial for cancer cells to acquire invasive phenotypes. In A549 lung adenocarcinoma cells, TGF-β elicited EMT in Smad-dependent manner and TNF-α accelerated this process, as confirmed by cell morphology, expression of EMT markers, capacity of gelatin lysis and cell invasion. TNF-α stimulated the phosphorylation of Smad2 linker region, and this effect was attenuated by inhibiting MEK or JNK pathway. Comprehensive expression analysis unraveled genes differentially regulated by TGF-β and TNF-α, such as cytokines, chemokines, growth factors and ECM (extracellular matrices), suggesting the drastic change in autocrine/paracrine signals as well as cell-to-ECM interactions. Integrated analysis of microRNA signature enabled us to identify a subset of genes, potentially regulated by microRNAs. Among them, we confirmed TGF-β-mediated induction of miR-23a in lung epithelial cell lines, target genes of which were further identified by gene expression profiling. Combined with in silico approaches, we determined HMGN2 as a downstream target of miR-23a. These findings provide a line of evidence that the effects of TGF-β and TNF-α were partially mediated by microRNAs, and shed light on the complexity of molecular events elicited by TGF-β and TNF-α.
Endocytosis and Recycling of Tight Junction Proteins in Inflammation

A critical function of the epithelial lining is to form a barrier that separates luminal contents from the underlying interstitium. This barrier function is primarily regulated by the apical junctional complex (AJC) consisting of tight junctions (TJs) and adherens junctions (AJs) and is compromised under inflammatory conditions. In intestinal epithelial cells, proinflammatory cytokines, for example, interferon-gamma (IFN-γ), induce internalization of TJ proteins by endocytosis. Endocytosed TJ proteins are passed into early and recycling endosomes, suggesting the involvement of recycling of internalized TJ proteins. This review summarizes mechanisms by which TJ proteins under inflammatory conditions are internalized in intestinal epithelial cells and point out comparable mechanism in nonintestinal epithelial cells.
Impaired Hyperglycemia-Induced Delay in Gastric Emptying in Patients With Type 1 Diabetes Deficient for Islet Amyloid Polypeptide

OBJECTIVE—Slowing of gastric emptying by hyperglycemia, a physiological response to minimize postprandial hyperglycemia, may be impaired in patients with type 1 diabetes. The causes and consequences on glucose homeostasis are unknown. RESEARCH DESIGN AND METHODS—Consequences of euglycemia- and hyperglycemia-induced changes in gastric emptying on postprandial glucose fluxes and excursions were studied in 10 healthy subjects and 15 type 1 diabetic subjects after ingestion of a mixed meal using the double isotope approach ([6,6-2H2] and [1-13C]glucose) and scintigraphic measurements of gastric emptying. RESULTS—Gastric emptying was greater in type 1 diabetic subjects (90–120 min, P < 0.03), and 50% retention times were comparable in healthy subjects and type 1 diabetic subjects (167 ± 8 vs. 152 ± 10, P = 0.32). Hyperglycemia markedly delayed gastric emptying in healthy subjects but did not alter it in type 1 diabetic subjects (50% retention time 222 ± 18 vs. 167 ± 8 min, P = 0.003 and 148 ± 9 vs. 152 ± 10 min, P = 0.51). Plasma islet amyloid polypeptide (IAPP) increased approximately fourfold in healthy subjects (P < 0.001), whereas it was undetectable in type 1 diabetic subjects. IAPP replacement, using the analog pramlintide, in type 1 diabetic subjects slowed gastric emptying to a comparable extent, as did hyperglycemia in healthy subjects (P < 0.14), and greatly reduced postprandial hyperglycemia (P < 00.1). Meal-derived glucose appearance in plasma (10.7 ± 0.5 vs. 6.8 ± 0.7 μmol · kg−1 · min−1, P < 0.001) was reduced, and splanchnic glucose sequestration increased (14.0 ± 3.0 vs. 25.0 ± 6.0%, P = 0.04). CONCLUSIONS—In patients with type 1 diabetes the ability to delay gastric emptying in response to hyperglycemia is impaired. This impairment contributes to exaggerated rates of meal-derived glucose appearance and, ultimately, postprandial glucose excursions.
Service Sector Growth, Public External Debt and Economic Growth: A Relook in to the Experience of Ethiopia

Ethiopia is experiencing a robust economic growth in recent times which is mainly due to the expansion in service sector though; agriculture is its mainstay in terms of employment and export earnings. During this time, Ethiopia has also experienced rising external debt mainly of public sector. Several studies have appeared in recent times on the negative impact of growing debt on economic growth. This paper is an attempt to relook into the relationship of external debt and economic growth in Ethiopia. It traces out the effect of service sector growth, agricultural growth along with public sector external debt on economic growth using time series methods. For this purpose the study employed ARDL co-integration technique and the error correction model for investigating long run as well as short run relationship among these variables for the study period 1981-2012. The empirical evidence suggests that service sector growth and agricultural sector growth have contributed positively to the economic growth of Ethiopia. Contrary to the apprehensions about public external debt, it does not have significant influence on economic growth. In view of these findings it is suggested that Ethiopia should continue with the existing agricultural and service sector policies and need not excessively worry with its growing foreign debt.
Sufficient conditions for optimal multicast communication

In this paper, we give a general technique for computing optimal multicast calling schedules in any multiprocessor system that utilizes a direct network interconnection structure as long as a few simple conditions are satisfied. Since almost any real system will satisfy these conditions, this result essentially means that multicast can always be performed in [log(d+1)] phases where d is the number of multicast destinations. In particular, previous results on optimal multicast algorithms in specific direct network topologies are simply corollaries of our result.
Persistent spatial working memory deficits in rats following in utero RNAi of Dyx 1 c 1

†Department of Psychology/Behavioral Neuroscience, University of Connecticut, Storrs, CT, ‡Department of Psychology, Rhode Island College, Providence, RI, §Department of Physiology and Neurobiology, University of Connecticut, Storrs, CT, ¶Division of Molecular Psychiatry, Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, Yale University School of Medicine, New Haven, CT, and **Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA *Corresponding author: C. E. Szalkowski, University of Connecticut, 406 Babbidge Road, Unit 1020, Storrs, CT 06269, USA. E-mail: Caitlin.cleary@uconn.edu
Improving Usability via Access Decomposition and Policy Refinement

Commodity operating systems fail to meet the security, resource management and integration expectations of users. We propose a unified solution based on a capability framework as it supports fine grained objects, straightforward access propagation and virtualizable interfaces and explore how to improve resource use via access decomposition and policy refinement with minimum interposition. We argue that only a small static number of scheduling policies are needed in practice and advocate hierarchical policy specification and central realization.
Tear Osmolarity, Break-up Time and Schirmer’s Scores in Parkinson’s Disease

Objectives: Dry eye is an important problem in Parkinson’s disease (PD) with a potential to affect life quality. Tear osmolarity, accepted as the gold standard in dry eye diagnosis, has not been studied in this subset of patients so far. Therefore, in this study we aimed to evaluate tear osmolarity, Schirmer’s test scores and tear film break-up time (TBUT) in PD patients. Ma­te­ri­als and Met­hods: PD patients with a minimum follow-up of 1 year and healthy controls who admitted for refractive abnormalities were enrolled to the study. Subjects using any systemic medication with a possibility to affect tear tests were not included in the study. The presence of any ocular surface disorder, previous ocular surgery, previous dry eye diagnosis, any topical ophthalmic medication or contact lens use were other exclusion criteria. Age, gender, disease duration, and Hoehn and Yahr (H&Y) score for disease severity were noted, and blink rate (BR), Schirmer’s test score, TBUT and tear osmolarity of the right eye were measured in both groups. Re­sults: Thirty-seven PD patients and 37 controls were enrolled to the study. The groups were age and gender matched. The mean disease duration and H&Y score were 5.70±2.64 years and 1.70±0.93, respectively. H&Y staging and disease duration were not correlated to BR, Schirmer’s scores, TBUT, or tear osmolarity (p>0.05). The mean BR was 8.54±4.99 blinks/minute in PD patients and 11.97±6.36 blinks/minute in the control group. Mean Schirmer’s scores, TBUT and osmolarity values were 9.08±4.46 mm, 11.38±4.05 seconds and 306.43±12.63 mOsm/L in the PD group and 17.16±9.57 mm, 12.81±3.66 seconds and 303.81±16.13 mOsm/L in the control group. The differences were significant only in BR and Schirmer’s scores. Conclusion: BR and Schirmer’s scores decreased significantly in PD patients. Although not significant, the demonstrated tear osmolarity increment might be important to document the dry eye and inflammatory process of the ocular surface in PD patients.
Gab Docking Proteins in Cardiovascular Disease, Cancer, and Inflammation

The docking proteins of the Grb2-associated binder (Gab) family have emerged as crucial signaling compartments in metazoans. In mammals, the Gab proteins, consisting of Gab1, Gab2, and Gab3, are involved in the amplification and integration of signal transduction evoked by a variety of extracellular stimuli, including growth factors, cytokines, antigens, and other molecules. Gab proteins lack the enzymatic activity themselves; however, when phosphorylated on tyrosine residues, they provide binding sites for multiple Src homology-2 (SH2) domain-containing proteins, such as SH2-containing protein tyrosine phosphatase 2 (SHP2), phosphatidylinositol 3-kinase regulatory subunit p85, phospholipase Cγ, Crk, and GC-GAP. Through these interactions, the Gab proteins transduce signals from activated receptors into pathways with distinct biological functions, thereby contributing to signal diversification. They are known to play crucial roles in numerous physiological processes through their associations with SHP2 and p85. In addition, abnormal Gab protein signaling has been linked to human diseases including cancer, cardiovascular disease, and inflammatory disorders. In this paper, we provide an overview of the structure, effector functions, and regulation of the Gab docking proteins, with a special focus on their associations with cardiovascular disease, cancer, and inflammation.
The Arabidopsis CDK inhibitor ICK3/KRP5 is rate limiting for primary root growth and promotes growth through cell elongation and endoreduplication

The coordination of plant cell division and expansion controls plant morphogenesis, development, and growth. Cyclin-dependent kinases (CDKs) are not only key regulators of cell division but also play an important role in cell differentiation. In plants, CDK activity is modulated by the binding of INHIBITOR OF CDK/KIP-RELATED PROTEIN (ICK/KRP). Previously, ICK2/KRP2 has been shown to mediate auxin responses in lateral root initiation. Here are analysed the roles of all ICK/KRP genes in root growth. Analysis of ick/krp null-mutants revealed that only ick3/krp5 was affected in primary root growth. ICK3/KRP5 is strongly expressed in the root apical meristem (RAM), with lower expression in the expansion zone. ick3/krp5 roots grow more slowly than wildtype controls, and this results not from reduction of division in the proliferative region of the RAM but rather reduced expansion as cells exit the meristem. This leads to shorter final cell lengths in different tissues of the ick3/krp5 mutant root, particularly the epidermal non-hair cells, and this reduction in cell size correlates with reduced endoreduplication. Loss of ICK3/KRP5 also leads to delayed germination and in the mature embryo ICK3/KRP5 is specifically expressed in the transition zone between root and hypocotyl. Cells in the transition zone were smaller in the ick3/krp5 mutant, despite the absence of endoreduplication in the embryo suggesting a direct effect of ICK3/KRP5 on cell growth. It is concluded that ICK3/KRP5 is a positive regulator of both cell growth and endoreduplication.
The host galaxy/AGN connection in nearby early-type galaxies. A new view of the origin of the radio-

This is the third in a series of three papers exploring the connection between the multiwavelength properties of AGN in nearby early-type galaxies and the characteristics of their hosts. Starting from an initial sample of 332 galaxies, we selected 116 AGN candidates requiring the detection of a radio source with a flux limit of � 1 mJy, as measured from 5 GHz VLA observations. In Paper I we classified the objects with available archival HST images into "core" and "power-law" galaxies, discriminating on the basis of the nuclear slope of their brightness profiles. We used HST and Chandra data to isolate the nuclear emission of these galaxies in the optical and X-ray bands, thus enabling us (once combined with the radio data) to study the multiwavelength behaviour of their nuclei. The properties of the nuclei hosted by the 29 core galaxies were presented in Paper II. Core galaxies invariably host a radio-loud nucleus, with a median radio-loudness of Log R = 3.6 and an X-ray based radio-loudness parameter of Log RX = -1.3. Here we discuss the properties of the nuclei of the 22 "power-law" galaxies. They show a substantial excess of optical and X-ray emission with respect to core galaxies at the same level of radio luminosity. Conversely, their radio-loudness parameters, Log R � 1.6 and Log RX � -3.3, are similar to those measured in Seyfert galaxies. Thus the radio-loudness of AGN hosted by early-type galaxies appears to be univocally related to the host's brightness profile: radio-loud AGN are only hosted by core galaxies, while radio-quiet AGN are found only in power-law galaxies. The brightness profile is determined by the galaxy's evolution, through its merger history; our results suggest that the same process sets the AGN flavour. In this scenario, the black holes hosted by the merging galaxies rapidly sink toward the centre of the newly formed object, setting its nuclear configuration, described by e.g. the total mass, spin, mass ratio, or separation of the SMBHs. These parameters are most likely at the origin of the different levels of the AGN radio-loudness. This connection might open a new path toward understanding the origin of the radio-loud/radio-quiet AGN dichotomy and provide us with a further tool for exploring the co-evolution of galaxies and supermassive black holes.
Technical Efficiency in Crop Production: A Region-wise Analysis §

The technical efficiency in crop production has been reported in different regions as well as in the state of Punjab to show how different regions have adopted the latest technology. Technical efficiency of individual farms has been estimated through stochastic frontier production function analysis. The production function estimates have pointed towards the presence of disguised unemployment in the sub-mountainous region of the Punjab state. The technical efficiency has shown a wide variation across regions. The average technical efficiency has been found maximum in the central region (90 per cent), followed by south-western and sub-mountainous regions. The main drivers of inefficiency have been identified as experience in agriculture and age of a farmer. The policy intervention to improve technical efficiency being not the same for all the regions, the study has observed that the state would benefit more if policy interventions are developed at the local level.
Particles : presupposition triggers or context markers

This paper discusses two possible formal approaches to the semantic/pragmatic particles of a subclass of the modal particles. It may well be that the approaches can be applied to other particles or that they can be applied to certain intonational patterns (e.g. contrastive stress), to morphemes (past tense, agreement) or to words (pronouns), constructions (some uses of definite descriptions, clefts), but I will not try to to show that here.
Does Sample Size Matter in Qualitative Research?: A Review of Qualitative Interviews in is Research

This study examines 83 IS qualitative studies in leading IS journals for the following purposes: (a) identifying the extent to which IS qualitative studies employ best practices of justifying sample size; (b) identifying optimal ranges of interviews for various types of qualitative research; and (c) identifying the extent to which cultural factors (such as journal of publication, number of authors, world region) impact sample size of interviews. Little or no rigor for justifying sample size was shown for virtually all of the IS studies in this dataset. Furthermore, the number of interviews conducted for qualitative studies is correlated with cultural factors, implying the subjective nature of sample size in qualitative IS studies. Recommendations are provided for minimally acceptable practices of justifying sample size of interviews in qualitative IS studies.