Miracle-dz/UniFAR-FTUs huggingface dataset:
Reduction of recurrent ischemia with abciximab during continuous ECG-ischemia monitoring in patients with unstable angina refractory to standard treatment (CAPTURE).

BACKGROUND In the CAPTURE (c7E3 Fab Anti Platelet Therapy in Unstable REfractory angina) trial, 1265 patients with refractory unstable angina were treated with abciximab or placebo, in addition to standard treatment from 16 to 24 hours preceding coronary intervention through 1 hour after intervention. To investigate the incidence of recurrent ischemia and the ischemic burden, a subset of 332 patients (26%) underwent continuous vector-derived 12-lead ECG-ischemia monitoring. METHODS AND RESULTS Patients were monitored from start of treatment through 6 hours after coronary intervention. Ischemic episodes were detected in 31 (18%) of the 169 abciximab and in 37 (23%) of the 163 placebo patients (NS). Only 9 (5%) of abciximab versus 22 (14%) of placebo patients had >/=2 ST episodes (P<0.01). In patients with ischemia, abciximab significantly reduced total ischemic burden (P<0.02), which was calculated alternatively as the total duration of ST episodes per patient, the area under the curve of the ST vector magnitude during episodes, or the sum of the areas under the curves of 12 leads during episodes. Twenty-one patients (6%) suffered a myocardial infarction (MI) (18) or died (3) within 5 days of treatment. The presence of asymptomatic and symptomatic ST episodes during the monitoring period preceding coronary intervention was associated with an increased relative risk of these events of 3.2 (95% CI 1.4, 7.4) and 4.1 (95% CI 1.4, 12.2), respectively. CONCLUSIONS Recurrent ischemia predicts MI or death within 5 days of follow-up. Treatment with abciximab is associated with a reduction of frequent ischemia and a reduction of total ischemic burden in patients with refractory unstable angina. As such, patients with ischemia derive particularly high benefit from abciximab.
Moving to the Speed of Sound: Context Modulation of the Effect of Acoustic Properties of Speech

Suprasegmental acoustic patterns in speech can convey meaningful information and affect listeners' interpretation in various ways, including through systematic analog mapping of message-relevant information onto prosody. We examined whether the effect of analog acoustic variation is governed by the acoustic properties themselves. For example, fast speech may always prime the concept of speed or a faster response. Alternatively, the effect may be modulated by the context-dependent interpretation of those properties; the effect of rate may depend on how listeners construe its meaning in the immediate linguistic or communicative context. In two experiments, participants read short scenarios that implied, or did not imply, urgency. Scenarios were followed by recorded instructions, spoken at varying rates. The results show that speech rate had an effect on listeners' response speed; however, this effect was modulated by discourse context. Speech rate affected response speed following contexts that emphasized speed, but not without such contextual information.
Granulocytes in Helminth Infection - Who is Calling the Shots?

Helminths are parasitic organisms that can be broadly described as “worms” due to their elongated body plan, but which otherwise differ in shape, development, migratory routes and the predilection site of the adults and larvae. They are divided into three major groups: trematodes (flukes), which are leaf-shaped, hermaphroditic (except for blood flukes) flatworms with oral and ventral suckers; cestodes (tapeworms), which are segmented, hermaphroditic flatworms that inhabit the intestinal lumen; and nematodes (roundworms), which are dioecious, cylindrical parasites that inhabit intestinal and peripheral tissue sites. Helminths exhibit a sublime co-evolution with the host´s immune system that has enabled them to successfully colonize almost all multicellular species present in every geographical environment, including over two billion humans. In the face of this challenge, the host immune system has evolved to strike a delicate balance between attempts to neutralize the infectious assault versus limitation of damage to host tissues. Among the most important cell types during helminthic invasion are granulocytes: eosinophils, neutrophils and basophils. Depending on the specific context, these leukocytes may have pivotal roles in host protection, immunopathology, or facilitation of helminth establishment. This review provides an overview of the function of granulocytes in helminthic infections.
Lentivirus-Mediated ERK2 siRNA Reduces Joint Capsule Fibrosis in a Rat Model of Post-Traumatic Joint Contracture

Extracellular signal-regulated kinase (ERK)-2 is presumed to play an important role in the development of post-traumatic joint contractures. Using a rat injury model, we investigated whether treatment with ERK2 small interfering RNA (siRNA) could reduce the extent of joint capsule fibrosis after an induced injury. Rats were separated into three groups (n = 32 each): non-operated control group, operated contracture group and contracture-treatment group. Stable post-traumatic joint contracture was created through surgical intra-articular joint injury followed by eight weeks of immobilization. In the contracture-treatment group, the rats were treated with lentivirus (LV)-mediated ERK2 siRNA at days 3 and 7 post-surgery. The posterior joint capsule was assessed by western blotting, immunohistochemistry and biochemical analysis for changes in ERK2, phosphorylated (p)-ERK2, myofibroblast, total collagen and relative collagen Type III expression level. Biomechanical testing was used to assess the development of flexion contractures. Statistical analysis was performed using an analysis of variance. In the operated contracture group, rats that developed flexion contractures also showed elevated phosphorylated p-ERK2 expression. In the contracture-treatment group, ERK2 siRNA significantly reduced p-ERK2 expression levels, as well as the severity of flexion contracture development (p < 0.01). Myofibroblast numbers and measurements of total collagen content were also significantly reduced following ERK2 siRNA (p < 0.01). Relative collagen type III expression as a proportion of total of Types I and III collagen, however, was significantly increased in response to ERK2 siRNA (p < 0.01). Our findings demonstrate a role for ERK2 in the induction of joint capsule fibrosis after injury. Furthermore, we show that development of flexion contractures and the resultant increase of joint capsule fibrosis can be reduced by LV-mediated ERK2 siRNA treatment.
Effects of Reducing Suppressors of Cytokine Signaling-3 (SOCS3) Expression on Dendritic Outgrowth and Demyelination after Spinal Cord Injury

Suppressors of cytokine signaling-3 (SOCS3) is associated with limitations of nerve growth capacity after injury to the central nervous system. Although genetic manipulations of SOCS3 can enhance axonal regeneration after optic injury, the role of SOCS3 in dendritic outgrowth after spinal cord injury (SCI) is still unclear. The present study investigated the endogenous expression of SOCS3 and its role in regulating neurite outgrowth in vitro. Interleukin-6 (IL-6) induces SOCS3 expression at the mRNA and protein levels in neuroscreen-1 (NS-1) cells. In parallel to SOCS3 expression, IL-6 induced tyrosine phosphorylation of signal transducer and activator of transcription 3 (STAT3) in NS-1 cells. Lentiviral delivery of short hairpin RNA (shSOCS3) (Lenti-shSOCS3) to decrease SOCS3 expression into NS-1 cells enhanced IL-6-induced tyrosine phosphorylation of STAT3 (P-STAT3 Tyr705) and promoted neurite outgrowth. In addition, we determined if reduction of SOCS3 expression by microinjection of Lenti-shSOCS3 into spinal cord enhances dendrite outgrowth in spinal cord neurons after SCI. Knocking down of SOCS3 in spinal cord neurons with Lenti-shSOCS3 increased complete SCI-induced P-STAT3 Tyr705. Immunohistochemical analysis showed that complete SCI induced a significant reduction of microtubule association protein 2-positive (MAP-2+) dendrites in the gray and white matter at 1 and 4 weeks after injury. The SCI-induced reduction of MAP-2+ dendrites was inhibited by infection with Lenti-shSOCS3 in areas both rostral and caudal to the lesion at 1 and 4 weeks after complete SCI. Furthermore, shSOCS3 treatment enhanced up-regulation of growth associated protein-43 (GAP-43) expression, which co-localized with MAP-2+ dendrites in white matter and with MAP-2+ cell bodies in gray matter, indicating Lenti-shSOCS3 may induce dendritic regeneration after SCI. Moreover, we demonstrated that Lenti-shSOCS3 decreased SCI-induced demyelination in white matter of spinal cord both rostral and caudal to the injury site 1 week post-injury, but not rostral to the injury at 4 weeks post-injury. Importantly, similar effects as Lenti-shSOCS3 on increasing MAP-2+ intensity and dendrite length, and preventing demyelination were observed when a second shSOCS3 (Lenti-shSOCS3 #2) was applied to rule out the possibilities of off target effects of shRNA. Collectively, these results suggest that knocking down of SOCS3 enhances dendritic regeneration and prevents demyelination after SCI.
An Adaptive TDMA Protocol for Soft Real-Time Wireless Communication among Mobile Autonomous Agents

Interest on using mobile autonomous agents has been growing, recently, due to their capacity to cooperate for diverse purposes, from rescue to demining and security. Such cooperation typically requires the exchange of state data that is time sensitive and thus, applications should be aware of data temporal coherency. In order to provide such information a real-time communications protocol must be used to prevent unbounded latency of message delivery. This is, however, not a trivial task when using wireless links because of their poor reliability properties, exhibiting high bit error rates, omissions and inconsistencies. This paper describes such a communication protocol that adapts itself to the current conditions of the medium attempting to deliver an adequate timeliness while using the least bandwidth. The protocol operates over IEEE 802.11 networks in both managed and ad-hoc modes and it is fully distributed. It has been developed within the framework of the CAMBADA project at the University of Aveiro, Portugal, which aims at developing a robotic soccer team. This paper describes the protocol and presents some preliminary experimental results.
Stability analysis of unsteady three-dimensional viscous flow over a permeable stretching/shrinking surface

In this paper, a theoretical and numerical study on the unsteady three-dimensional boundary layer flow of a viscous fluid past a permeable stretching/shrinking sheet is considered. Similarity transformation is used to reduce the governing system of nonlinear partial differential equations into a system of ordinary differential equations. These equations are then solved numerically by using the “bvp4c” function in MATLAB. The effects of the governing parameters, namely the unsteadiness parameter, the stretching/shrinking parameter, the suction parameter and the ratio of the surface velocity gradients on the skin friction coefficients, as well as the velocity profiles are presented and discussed. Multiple solutions are found for a certain range of the governing parameters. Stability analysis has been performed to determine which solution is stable and physically realisable.
Ligand-Gating by Ca2+ Is Rate Limiting for Physiological Operation of BKCa Channels

Large conductance Ca2+- and voltage-activated potassium channels (BKCa) shape neuronal excitability and signal transduction. This reflects the integrated influences of transmembrane voltage and intracellular calcium concentration ([Ca2+]i) that gate the channels. This dual gating has been mainly studied as voltage-triggered gating modulated by defined steady-state [Ca2+]i, a paradigm that does not approximate native conditions. Here we use submillisecond changes of [Ca2+]i to investigate the time course of the Ca2+-triggered gating of BKCa channels expressed in Chinese hamster ovary cells at distinct membrane potentials in the physiological range. The results show that Ca2+ can effectively gate BKCa channels and that Ca2+ gating is largely different from voltage-driven gating. Most prominently, Ca2+ gating displays a pronounced delay in the millisecond range between Ca2+ application and channel opening (pre-onset delay) and exhibits slower kinetics across the entire [Ca2+]i-voltage plane. Both characteristics are selectively altered by co-assembled BKβ4 or an epilepsy-causing mutation that either slows deactivation or speeds activation and reduces the pre-onset delay, respectively. Similarly, co-assembly of the BKCa channels with voltage-activated Ca2+ (Cav) channels, mirroring the native configuration, decreased the pre-onset delay to submillisecond values. In BKCa–Cav complexes, the time course of the hyperpolarizing K+-current response is dictated by the Ca2+ gating of the BKCa channels. Consistent with Cav-mediated Ca2+ influx, gating was fastest at hyperpolarized potentials, but decreased with depolarization of the membrane potential. Our results demonstrate that under experimental paradigms meant to approximate the physiological conditions BKCa channels primarily operate as ligand-activated channels gated by intracellular Ca2+ and that Ca2+ gating is tuned for fast responses in neuronal BKCa–Cav complexes.
Determinants of Survival After Sorafenib Failure in Patients With BCLC-C Hepatocellular Carcinoma in Real-World Practice

AbstractSorafenib may improve progression-free survival (PFS) and overall survival (OS) of advanced hepatocellular carcinoma (HCC). However, the survival benefit is short lived and survivals after progressive disease (PD) have not been well characterized. This study aimed to evaluate the survival predictors of OS and postprogression survival (PPS) in advanced HCC patients receiving sorafenib treatment.Consecutive 149 HCC patients receiving sorafenib under National Health Insurance were retrospectively enrolled. All patients fulfilled the reimbursement criteria: Barcelona Clinic Liver Cancer stage C HCC with macroscopic vascular invasion or extrahepatic metastasis (Mets), and Child–Pugh class A. Radiologic assessment was performed at a 2-month interval using modified Response Evaluation Criteria in Solid Tumors. Patients who maintained Eastern Cooperative Oncology Group ⩽2 and Child–Pugh class A at PD were assumed to be candidates for second-line treatment.During the median follow-up period of 7.5 months (range, 1.1–18.5), PD developed in 120 (80.5%) patients and 96 (64.4%) deaths occurred. The median PFS, OS, and PPS were 2.5, 8.0, and 4.6 months, respectively. In general, patients with Mets only had better OS and PPS than those with portal vein invasion. Independent predictors of OS include baseline performance status (hazard ratio [HR] = 1.956), tumor size (HR = 1.597), alpha-fetoprotein (HR = 1.869), discontinuation of sorafenib due to liver function deterioration (LD) (HR = 6.142), or concurrent PD and LD (HR = 2.661) and PD within 4 months (HR = 5.164). Independent predictors of PPS include deteriorated performance status (HR = 7.680), deteriorated liver functions (HR = 5.603), bilirubin (HR = 2.114), early PD (HR = 6.109), and new extrahepatic lesion (HR = 1.804). In 46 candidates for second-line trials, development of new extrahepatic lesion independently predicts poorer PPS (HR = 3.669). In conclusion performance status, liver functions, early disease progression, and progression pattern are important determinants of survival after sorafenib failure. These factors should be considered in clinical practice and second-line trial designs for patients with sorafenib failure.
The conjugacy problem in right-angled Artin groups and their subgroups

We prove that the conjugacy problem in right-angled Artin groups (RAAGs), as well as in a large and natural class of subgroups of RAAGs, can be solved in linear-time. This class of subgroups contains, for instance, all graph braid groups (i.e. fundamental groups of configuration spaces of points in graphs), many hyperbolic groups, and it coincides with the class of fundamental groups of ``special cube complexes'' studied independently by Haglund and Wise.
Inter-Calibrating SMMR, SSM/I and SSMI/S Data to Improve the Consistency of Snow-Depth Products in China

Long-term snow depth/snow water equivalent (SWE) products derived from passive microwave remote sensing data are fundamental for climatological and hydrological studies. However, the temporal continuity of the products is affected by the updating or replacement of passive microwave sensors or satellite platforms. In this study, we inter-calibrated brightness temperature (Tb) data obtained from the Special Sensor Microwave Imager (SSM/I) and the Special Sensor Microwave Imager/Sounder (SSMI/S). Then, we evaluated the consistency of the snow cover area (SCA) and snow depth derived from the Scanning Multichannel Microwave Radiometer (SMMR), SSM/I and SSMI/S. The results indicated that (1) the spatial pattern of the SCA derived from the SMMR and SSM/I data was more consistent after calibration than before; (2) the relative biases in the SCA and snow depth in China between the SSM/I and SSMI/S data decreased from 42.42% to 1.65% and from 66.18% to −1.5%, respectively; and (3) the SCA and snow depth derived from the SSM/I data carried on F08, F11 and F13 were highly consistent. To obtain consistent snow depth and SCA products, inter-sensor calibrations between SMMR, SSM/I and SSMI/S are important. In consideration of the snow data product continuation, we suggest that the brightness temperature data from all sensors be calibrated based on SSMI/S.
A SMUGGLING GAME WITH THE SECRECY OF SMUGGLER'S INFORMATION

This paper deals with a smuggling game with multiple stages, in which Customs and a smuggler participate. Customs and the smuggler are allowed to take an action of patrol and smuggling, respectively, within the limited number of chances. Customs obtains reward by the capture of the smuggler and the smuggler gets reward by the success of smuggling. The reward or the payoff of the game is brought at each stage and is assumed to be zero-sum. Almost all past researches modeled their games by the so- called complete information game and they assumed that each player knows the past strategies taken by his opponent or never knows them. Recently, we recognize that information is crucial to the results of the games. In this paper, we deal with a smuggling game with incomplete information, where information acquisition is asymmetric between players and is disadvantageous to Customs, and we evaluate the value of information by developing a computational methodology to derive Bayesian equilibrium.
Brokerage as a Public Good: The Externalities of Network Hubs for Different Formal Roles in Creative Organizations

Although much is known about how brokerage positions in social networks help individuals improve their own performance, we know little about the impact of brokers on those around them. Our study investigates brokerage as a public good. We focus on the positive and negative externalities of specific kinds of brokers: “hubs,” who act as the main interfaces between members of their own network community (“network neighbors”) and members of other communities. Because hubs access diverse knowledge and perspectives, they create positive externalities by providing novel ideas to their network neighbors. But hubs also generate negative externalities: extensive cross-community activity puts heavy demands on their attention and time, so that hubs may not provide strong commitment to their neighbors’ projects. Because of this, network neighbors experience different externalities from hubs depending on their own formal role in projects. We use insights from our fieldwork in the French television game show industry to illustrate the mechanisms at play, and we test our theory with archival data on this industry from 1995 to 2012. Results suggest that the positive externalities of hubs help their neighbors contribute to the success of projects when these neighbors hold creativity-focused roles; yet the negative externalities of hubs hinder their neighbors’ contributions when they hold efficiency-focused roles.
Perceptions and Perceived Challenges Associated With a Hypothetical Career in Law Enforcement: Differences Among Male and Female College Students

Researchers have studied the experiences of female officers, but little is known about whether women, who are not yet officers, perceive future challenges and sex discrimination within a hypothetical law enforcement career. This study surveyed 387 male and female undergraduate students to compare perceptions and beliefs. Female students are less interested in a law enforcement career, perceive themselves as potentially less successful, and perceive less potential personal fulfillment. Women believe that current female officers receive less respect, acceptance, and opportunity. Perceptions of fulfillment and success significantly and positively impacted interest in a law enforcement career. In addition, fulfillment and success mediated the impact of sex on interest in a law enforcement career. These findings are important for recruiters because the sample comprises a target applicant pool that merits recruitment.
T Tauri Jet Physics Resolved Near the Launching Region with the Hubble Space Telescope

We present an analysis of the gas physics at the base of jets from five T Tauri stars based on high angular resolution optical spectra, using the Hubble Space Telescope Imaging Spectrograph (HST STIS). The spectra refer to a region within 100 AU of the star, i.e., where the collimation of the jet has just taken place. We form position-velocity (PV) images of the line ratios to get a global picture of the flow excitation. We then apply a specialized diagnostic technique to find the electron density, ionization fraction, electron temperature, and total density. Our results are in the form of PV maps of the obtained quantities, in which the gas behavior is resolved as a function of both radial velocity and distance from the jet axis. They highlight a number of interesting physical features of the jet collimation region, including regions of extremely high density, asymmetries with respect to the axis, and possible shock signatures. Finally, we estimate the jet mass and angular momentum outflow rates, both of which are fundamental parameters in constraining models of accretion-ejection structures, particularly if the parameters can be determined close to the jet footpoint. Comparing mass flow rates for cases where the mass accretion rate is available in the literature (i.e., for DG Tau, RW Aur, and CW Tau) reveals a mass ejection-to-accretion ratio of 0.01-0.07. Finally, where possible (i.e., for DG Tau and CW Tau), both mass and angular momentum outflow rates are resolved into higher and lower velocity jet material. For the clearer case of DG Tau, this reveals that the more collimated higher velocity component plays a dominant role in mass and angular momentum transport.