Miracle-dz/UniFAR-FTUs huggingface dataset:
Plasmodium falciparum Hsp70-x: a heat shock protein at the host–parasite interface

Plasmodium falciparum 70 kDa heat shock proteins (PfHsp70s) are expressed at all stages of the pathogenic erythrocytic phase of the malaria parasite life cycle. There are six PfHsp70s, all of which have orthologues in other plasmodial species, except for PfHsp70-x which is unique to P. falciparum. This research highlights a number of original results obtained by a detailed bioinformatics analysis of the protein. Large-scale sequence analysis indicated the presence of an extended transit peptide sequence of PfHsp70-x which potentially directs it to the endoplasmic reticulum (ER). Further analysis showed that PfHsp70-x does not have an ER-retention sequence, suggesting that the protein transits through the ER and is secreted into the parasitophorous vacuole or beyond into the erythrocyte cytosol. These results are consistent with experimental findings. Next, possible interactions between PfHsp70-x and exported P. falciparum Hsp40s or host erythrocyte Hsp40 were interrogated by modelling and docking. Docking results indicated that interaction between PfHsp70-x and each of the Hsp40s, regardless of biological feasibility, seems equally likely. This suggests that J domain might not provide the specificity in the formation of unique Hsp70-Hsp40 complexes, but that the specificity might be provided by other domains of Hsp40s. By studying different structural conformations of PfHsp70-x, it was shown that Hsp40s can only bind when PfHsp70-x is in a certain conformation. Additionally, this work highlighted the possible dependence of the substrate-binding domain residues on the orientation of the α-helical lid for formation of the substrate-binding pocket.
FOLFIRI plus bevacizumab as a second-line therapy for metastatic intrahepatic cholangiocarcinoma.

AIM To evaluate the efficacy and tolerance of FOLFIRI plus bevacizumab treatment outcome as second-line treatment for metastatic intrahepatic cholangiocarcinoma. METHODS Thirteen consecutive patients with metastatic intrahepatic cholangiocarcinoma who were refractory to first-line therapy consisting of gemcitabine plus oxaliplatin-based first-line chemotherapy given intravenously via intra-arterial infusion were treated with FOLFIRI [irinotecan (180 mg/m² i.v. over 90 min) concurrently with folinic acid (400 mg/m² i.v. over 120 min) followed by fluorouracil (400 mg/m² i.v. bolus) then fluorouracil 2400 mg/m² intravenous infusion over 46 h] and bevacizumab (5 mg/kg) every 2 wk. Tumor response was evaluated by computed tomography scan every 4 cycles. RESULTS The best tumor responses using response evaluation criteria in solid tumor criteria were: complete response for 1 patient, partial response for 4 patients, and stable disease for 6 patients after 6 mo of follow-up. The response rate was 38.4% (95%CI: 12.5-89) and the disease control rate was 84.5% (95%CI: 42-100). Seven deaths occurred at the time of analysis, progression free survival was 8 mo (95%CI: 7-16), and median overall survival was 20 mo (95%CI: 8-48). No grade 4 toxic events were observed. Four grade 3 hematological toxicities and one grade 3 digestive toxicity occurred. An adaptive reduction in chemotherapy dosage was required in 2 patients due to hematological toxicity, and a delay in chemotherapy cycles was required for 3 patients. CONCLUSION FOLFIRI plus bevacizumab combination treatment showed promising efficacy and safety as second-line treatment for metastatic intrahepatic cholangiocarcinoma after failure of the first-line treatment of gemcitabine plus oxaliplatin chemotherapy.
Influence of Polymer Type on the Physical Properties and Release Profile of Papaverine Hydrochloride From Hard Gelatin Capsules.

BACKGROUND The capsule is one of the most important solid dosage forms in the pharmaceutical industry. It is easier and faster to produce than a tablet, because it requires fewer excipients. Generally, capsules are easy to swallow and mask any unpleasant taste of the substances used while their release profiles can be easily modified. Papaverine hydrochloride was used as a model substance to show different release profiles using different excipients. OBJECTIVES The main aim of the study was to analyze the impact of using different polymers on the release profile of papaverine hydrochloride from hard gelatin capsules. MATERIAL AND METHODS Six series of hard gelatin capsules containing papaverine hydrochloride as a model drug and different excipients were made. Then, the angle of repose, flow rate, mass flow rate and volume flow rate of the powders used for capsule production were analyzed. The uniform weight and disintegration time of the capsules were studied. The dissolution study was performed in a basket apparatus, while the amount of papaverine hydrochloride released was determined spectrophotometrically at 251 nm. RESULTS Only one formula of powder had satisfactory flow properties, while all formulas had good Hausner ratios. The best properties were from powder containing polyvinylpyrrolidone 10k. The disintegration time of capsules varied from 1:30 min to 2:00 min. As required by Polish Pharmacopoeia X, 80% of the active substance in all cases was released within 15 minutes. The capsules with polyvinylpyrrolidone 10k were characterized by the longest release. On the other hand, capsules containing microcrystalline cellulose had the fastest release profile. CONCLUSIONS Using 10% of different polymers, without changing the other excipients, had a significant impact on the physical properties of the powders and papaverine hydrochloride release profile. The two most preferred capsule formulations contained either polyvinylpyrrolidone 10k or microcrystalline cellulose.
The spatio-temporal dynamics of visual letter recognition

We applied the Bubbles technique to reveal directly the spatio-temporal features of uppercase Arial letter identification. We asked four normal readers to each identify 26,000 letters that were randomly sampled in space and time; afterwards, we performed multiple linear regressions on the participant's response accuracy and the space–time samples. We contend that each cluster of connected significant regression coefficients is a letter feature. To bridge the gap between the letter identification literature and this experiment, we also determined the relative importance of the features proposed in the letter identification literature. Results show clear modulations of the relative importance of the letter features of some letters across time, demonstrating that letter features are not always extracted simultaneously at constant speeds. Furthermore, of all the feature classes proposed in the literature, line terminations and horizontals appear to be the two most important for letter identification.
Oversubscription on multicore processors

Existing multicore systems already provide deep levels of thread parallelism; hybrid programming models and composability of parallel libraries are very active areas of research within the scientific programming community. As more applications and libraries become parallel, scenarios where multiple threads compete for a core are unavoidable. In this paper we evaluate the impact of task oversubscription on the performance of MPI, OpenMP and UPC implementations of the NAS Parallel Benchmarks on UMA and NUMA multi-socket architectures. We evaluate explicit thread affinity management against the default Linux load balancing and discuss sharing and partitioning system management techniques. Our results indicate that oversubscription provides beneficial effects for applications running in competitive environments. Sharing all the available cores between applications provides better throughput than explicit partitioning. Modest levels of oversubscription improve system throughput by 27% and provide better performance isolation of applications from their co-runners: best overall throughput is always observed when applications share cores and each is executed with multiple threads per core. Rather than ¿resource¿ symbiosis, our results indicate that the determining behavioral factor when applications share a system is the granularity of the synchronization operations.
Integration of declarative and constraint programming

Abstract Combining a set of existing constraint solvers into an integrated system of cooperating solvers is a useful and economic principle to solve hybrid constraint problems. In this paper we show that this approach can also be used to integrate different language paradigms into a unified framework. Furthermore, we study the syntactic, semantic and operational impacts of this idea for the amalgamation of declarative and constraint programming.
Social network visualization: Does partial edges affect user comprehension?

In a small-world resolution, Euler diagrams are tangentially augmented with graphs and are realized in social network analysis but one of the main issue is the visual clutter. One interesting way of reducing this clutter is to use partial edges when there are visual elements (edge and curve) crossings. This paper empirically evaluates the use of partial edges for a small-scaled Euler diagrams with graphs and tests whether Euler diagrams with partial edges are readable and interpretable. In this study, twenty participants were presented with eighteen manually drawn diagrams using a software which recorded the answers and the time taken to answer each question. The results indicate that there is no significant difference between diagrams having partial and non-partial edges in terms of accuracy and time (performance analysis) but users preferred partial edges to be aesthetically pleasing in terms of reading graphs in Euler diagrams and layout features (preference analysis), which means partial edges can be used as a strategy to avoid clutter. The results obtained from the task performance and preference will be useful in generating real small-world graphs in an optimal way. The paper concludes that partial edges in a graph does not significantly affect comprehension and as a further direction, our existing Euler diagrams with complete graphs (full edges) tool will be extended to partial edges and evaluated.
Comparison of Staphylococcal Beta-lactamase Detection Methods Summary Comparison of Staphylococcal Beta-lactamase Detection Methods

Beta-lactams such as penicillin are the most widely used antibiotics, and beta-lactamases are the greatest source of resistance to penicillins. An understanding of beta-lactamase detection is therefore valuable. Colorimetric, acidometric and iodometric tests that detect the beta-lactamase enzyme are efficient, cheap and fast methods. The effectiveness of modifications of these methods (3 acidometric, 3 iodometric, chromogenic) on 323 staphylococcal isolates was examined. Eighty-three of these isolates were coagulasepositive and 240 were coagulase-negative. Oxacillin and penicillin susceptibilities of the isolates were also determined by KirbyBauer disk diffusion test. In order to test beta-lactamase production, chromogenic cephalosporin nitrocefin disk test was used as reference method (85.5% and 83.3% of coagulase-positive and coagulase-negative isolates were beta-lactamase positive, respectively). Iodometric tests are easy to perform, cheap and fast methods. Iodometric slide test results were especially similar to nitrocefin disk test, and thus can be used in detecting staphylococcal beta-lactamase when chromogenic methods are not available. Acidometric methods were also effective for detection of coagulasepositive staphylococcal beta-lactamase.
Consistency in compensatory eating responses following acute exercise in inactive, overweight and obese women

It is often assumed that some individuals reliably increase energy intake (EI) post-exercise (‘compensators’) and some do not (‘non-compensators’), leading researchers to examine the characteristics that distinguish these two groups. However, it is unclear whether EI post-exercise is stable over time. The present study examined whether compensatory eating responses to a single exercise bout are consistent within individuals across three pairs of trials. Physically inactive, overweight/obese women (n 28, BMI 30·3 (sd 2·9) kg/m2) participated in three pairs of testing sessions, with each pair consisting of an exercise (30 min of moderate-intensity walking) and resting testing day. EI was measured using a buffet meal 1 h post-exercise/rest. For each pair, the difference in EI (EIdiff= EIex− EIrest) was calculated, where EIex is the EI of the exercise session and EIrest is the EI of the resting session, and women were classified as a ‘compensator’ (EIex>EIrest) or ‘non-compensator’ (EIex≤ EIrest). The average EI on exercise days (3328·0 (sd 1686·2) kJ) was similar to those on resting days (3269·4 (sd 1582·4) kJ) (P= 0·67). Although EI was reliable within individuals across the three resting days (intraclass correlation coefficient (ICC) 0·75, 95 % CI 0·60, 0·87; P< 0·001) and three exercise days (ICC 0·83, 95 % CI 0·70, 0·91; P< 0·001), the ICC for EIdiff across the three pairs of trials was low (ICC 0·20, 95 % CI − 0·02, 0·45; P= 0·04), suggesting that compensatory eating post-exercise is not a stable construct. Moreover, the classification of ‘compensators’/‘non-compensators’ was not reliable (κ =− 0·048; P= 0·66). The results were unaltered when ‘relative’ EI was used, which considers the energy expenditure of the exercise/resting sessions. Acute compensatory EI following an exercise bout is not reliable in overweight women. Seeking to understand what distinguishes ‘compensators’ from ‘non-compensators’ based on a single eating episode post-exercise is not justified.
A physicochemical approach to design bioactive scaffolds for tissue engineering

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A Note on the SPICE Method

In this article, we analyze the SPICE method developed in , and establish its connections with other standard sparse estimation methods such as the Lasso and the LAD-Lasso. This result positions SPICE as a computationally efficient technique for the calculation of Lasso-type estimators. Conversely, this connection is very useful for establishing the asymptotic properties of SPICE under several problem scenarios and for suggesting suitable modifications in cases where the naive version of SPICE would not work.
On the normalization of subnormal possibility distributions: New investigations

Possibility distribution introduced by Zadeh ["Fuzzy sets as a basis for a theory of possibility theory", Fuzzy Sets Syst. 1 (1978) 3-28] in his introductory paper of possibility theory assumes a normal distribution, in the sense that it supposes the existence of at least one element s 0 of the universe of discourse U , for which the distribution ~ is fully compatible with the context of interest: ~ (s 0 )=1. However, when such element does no longer exist, it leads to a subnormal possibility distribution. This situation may arise from incomplete data, inconsistent statements, or contradictory beliefs. To deal with such case, many authors like Yager ["On the relationships of methods of aggregation evidence in expert systems", Cybern. Syst. , 16 (1985) 1-21; "A modification of the certainty measure to handle subnormal distributions", Fuzzy Sets Syst. , 20 (1986) 317-324], Dubois and Prade ["An alternative approach to the handling of subnormal possibility distributions--A critical comment on a proposal of Yager", Fuzzy Sets Syst. , 24 (1987) 123-126] have put forward some proposals in order to keep track of the consistency of the basic axioms attached to possibility and necessity measures. In this paper, the proposals are reviewed in the light of new results regarding some appealing criteria. Particularly, when subnormal distribution and normal distribution are encountered in the same level, intuitively, two approaches are possible: Either the subnormal distributions are risen up to a normal distribution level, or the normal ones are flatted down to agree with the normal ones. In both cases there is a sort of gaining or losing information. We review some of the proposal solutions. The flatting approach is mainly related to fuzzy arithmetic calculus while the rising effect is motivated by Dempster-Shafer theory of evidence and its normalization paradigm. The two approaches will also be investigated with respect to some appealing criteria like preference preservation, distance minimization, entropy, minimum/maximum specificity, and, further, particular interest is focused on information based uncertainty preservation. Later on, the proposals are discussed according to the f -certainty qualification where the greatest value h of the subnormal distribution is understood as a degree of certainty that must be attached to the resulting normal distribution.
brat: a Web-based Tool for NLP-Assisted Text Annotation

We introduce the brat rapid annotation tool (BRAT), an intuitive web-based tool for text annotation supported by Natural Language Processing (NLP) technology. BRAT has been developed for rich structured annotation for a variety of NLP tasks and aims to support manual curation efforts and increase annotator productivity using NLP techniques. We discuss several case studies of real-world annotation projects using pre-release versions of BRAT and present an evaluation of annotation assisted by semantic class disambiguation on a multicategory entity mention annotation task, showing a 15% decrease in total annotation time. BRAT is available under an open-source license from: http://brat.nlplab. org
Event-response systems: a technique for specifying multi-threaded dialogues

Event-Response Systems are a technique for specifying the syntax of multi-threaded dialogues. They are based on the paradigm of specifying system responses to events generated by the user. They can compactly represent the concurrency needed to implement multi-threaded dialogues. This concurrency support also allows interfaces to be structured differently than is possible with existing dialogue specification systems based on state transition specifications or grammars. This flexibility allows many interfaces, especially direct manipulation interfaces, to be specified with a more modular structure than most existing systems allow. Event-Response Systems are described formally, and a dialogue specification language based on the ERS formalism is informally presented. Some example uses and implementation techniques are also described.
Contraceptive prevalence and determinants among women of reproductive age group in Ogbomoso, Oyo State, Nigeria

Background The fertility rate in Nigeria is 5.7 children per woman. The contraceptive prevalence rate has been found to be low at 15% in 2013, compared to other countries such as the US and Pakistan. Objective The study aimed to assess the contraceptive prevalence among women of reproductive age in Ogbomoso town, and determinants of use, with a view to make appropriate recommendations that will enhance the uptake of family planning services. Materials and methods This is a descriptive cross-sectional study conducted with 560 respondents, using a multistage sampling technique. Data were retrieved using a semi-structured, pretested questionnaire. Results All the respondents were aware of contraception; however, only 49.7% (271) had ever used any method, while 25.4% (69) of the number who had ever used contraception were currently using a method. The methods being used were the traditional type (four [5.9%]), natural type (two [3.0%]), and modern type (63 [91.1%]). The predictors of contraception use included the age group of 40–49 years (odds ratio [OR] 14.1; confidence interval [CI] 3.06–73.24; P=0.0001); the married women were approximately four times more likely to use contraception than the single women (OR 4.5; CI 3.03–6.72; P<0.0001). The women with tertiary level of education were three times more likely to use contraception than those without formal education (OR 3.1; CI 1.13–9.95; P=0.0268), and the odds ratio of respondents with a positive attitude to using contraception more than those with negative attitude was 2 (OR 2; CI 1.41–2.91; P<0.0001). Conclusion In light of the advantages associated with contraception use, there needs to be a conscious effort, especially among health care workers, to educate women about contraception and encourage its use.
Developing a conceptual model for knowledge sharing

Knowledge sharing in an organization is a complex process with many factors influencing the activity. This paper reviews research on the topic and identifies many of the variables (or factors) identified by previous authors. We also identify where such factors have been measured empirically or investigated using qualitative techniques. Some shortcomings are identified and a possible avenue of research suggested that will provide further insight into what drives knowledge sharing in a modern organization. The paper focuses on describing the underlying conceptual framework for studying the problem using the individual knowledge worker and the knowledge sharing activity as the unit of analysis.
Relative Prices and Relative Prosperity

The positive correlation between PPP investment rates and PPP income levels across countries is one of the most robust findings of the empirical growth literature. We show that this relationship is almost entirely driven by differences in the price of investment relative to output across countries. When measured at domestic prices rather than at international prices, investment rates are little correlated with PPP incomes. We find that the high relative price of investment in poor countries is solely due to the low price of consumption goods in poor countries. Investment prices are no higher in poor countries than in rich countries. These facts suggest that the low PPP investment rates in poor countries are not due to low savings rates or to high tax or tariff rates on investment. Poor countries instead appear to be plagued by low efficiency in producing investment goods and in producing exportables to trade for machinery and equipment.
The safety and efficacy of gemcitabine for the treatment of bladder cancer

ABSTRACT Bladder cancer is a common type of cancer with an estimated incidence of more than 70,000 patients and had a mortality of 16,000 patients in the US in 2015. In more than 70% of cases the disease is diagnosed at the non-muscle invasive stage. However, muscle invasive or metastatic stages need multimodal treatment strategies including surgical treatment and chemotherapy in a neoadjuvant, adjuvant or palliative setting. Gemcitabine is a pyrimidine antimetabolite that has shown efficacy when used systemically in bladder cancer with only mild toxicity compared to other chemotherapeutic agents. This article aims to summarize the results of clinical trials in monotherapeutic, combined or sequential treatment strategies, especially considering efficacy and safety of the different therapeutic regimes.
Building a Practical Wi-Fi-Based Indoor Navigation System

This article presents the seven-step process involved in building a practical Wi-Fi-based indoor navigation system, which was implemented at the COEX complex in Seoul, Korea, in October 2010. The article describes the primary activities in each step using the COEX example. More than 200,000 users have downloaded the system since its first release. The successful launch of the COEX indoor navigation system suggests that indoor navigation is becoming a reality.