Miracle-dz/UniFAR-FTUs huggingface dataset:
Age and speleogenesis of epigenic gypsum caves in the northern Apennines (Italy)

Triassic and Messinian gypsum beds host the majority of the caves in the eastern flank of the northern Apennines. To date, more than six hundreds voids have been mapped, including the longest known epigenic gypsum cave system in the world (Spipola-Acquafredda, ∼11 km of tunnels) (De Waele et al., 2013). Superimposed caves are typically sub-horizontal (Klimchouk, 2000) and connected through vertical shafts, reflecting the palaeo base-level variations. When preserved, river terraces at the surface lie at the same palaeo altitude of the base level and horizontal cave passages. Notwithstanding the well-known geology of the area known (Vai and Martini, 2001), the age of these caves has been greatly underestimated in the past. Considering the rapid dissolution of the gypsum and uplifting of the area, the start of speleogenesis activity was considered to have occurred during the last glacial age. The age of karst voids can be only indirectly estimated by the dating of the infilling sediments. U-Th dating on carbonate speleothems provides high-precision and accurate ages (Hellstrom, 2003; Scholz and Hoffmann, 2008). We thus applied this methodology to 20 speleothems coming from 14 different caves belonging to the Monte Tondo, Spipola Acquafredda, Castelnuovo, Stella-Rio Basino and Brisighella systems. The results show that: i) caves were forming since at least∼300 ka; ii) the peak of speleogenesis was reached during relatively cold climate stages, when rivers formed terraces at the surface and aggradation caused paragenesis in the stable cave levels (Columbu et al., 2015). Besides the significant contribution to the understanding of the Apennines evaporite karst evolution, this study (and its further advancement) may also refine knowledge of the local vs regional uplifting rates and base-level variations since the late Pleistocene (Wegmann and Pazzaglia, 2009).
Sentinel node detection failure due to defective labeling and large particle size of Tc-99m antimony sulfide colloid

Introduction: Many radiotracers have been used for sentinel node mapping with acceptable results. The main difference between these radiotracers is the particle size. In the current study, we reported defective labeling of Tc-99m antimony sulfide colloid which resulted in large particle size. Methods: Tc-99m-Antimony sulfide colloid was used for axillary sentinel node mapping of 45 breast cancer patients. The prepared kits were turbid and were used for the first 15 patients. For the remaining 30 patients, we used a filter (GyroDisc CA-PC Cellulose Acetate Membrane; 30 mm; Pore size: 0.2 µm) after labeling to remove the possible large particles of the prepared kits. Results: On the lymphoscintigraphy images, at least one sentinel node could be identified in 5 and 29 patients of the unfiltered and filtered groups respectively (p=0.00001). Sentinel node detection by gamma probe was successful in 5 and 30 patients in the unfiltered and filtered groups respectively (p=0.000001). Conclusion: Tc-99-Antimopny sulfide colloid is a suitable radiotracer for sentinel node mapping of the breast cancer patients. In case of any unusual turbidity of the labeled kit, it should not be used or at least be filtered before injection.
The influence of length of implant on primary stability: An in vitro study using resonance frequency analysis

Background Primary stabilityis not sufficientin less contact area between the implant and bone, the healing process because will be disrupted due to micro-motions and fibrous tissue affects osseointegration. Material and Methods We implemented an in vitro experimental study of total 135 XiVE® implants were inserted in 22.5 bovine cow ribs with bone quality similar to a type IV human bone. Each rib end received a group of three different implant lengths, which were 8mm, 13mm and 15mm and had the same diameter 3.8mm. Immediately after the implant placement, its primary stability was measured using Osstell Mentor equipment. ANOVA Tukey’s honest to test the significant difference were performed for data analysis between the resonance measures of the different lengths of implants. Statistical significance was assessed at a level P< 0.05. Results A total of 45 implants were inserted for each length at cortical bone level. A significant difference between the three groups in favor of implant with 15mm length group (P = 0.000). Conclusions Increasing dental implant length is considered to play a fundamental role in increasing dental implant primary stability, even in poor bone quality, through controlling the bone preparation process. Key words:Dental implants, primary stability, resonance frequency analysis.
Chlorophyllase 1, a Damage Control Enzyme, Affects the Balance between Defense Pathways in Plants

Accumulation of reactive oxygen species (ROS) is central to plant response to several pathogens. One of the sources of ROS is the chloroplast because of the photoactive nature of the chlorophylls. Chlorophyllase 1 (encoded by AtCLH1) of Arabidopsis thaliana is quickly induced after tissue damage (e.g., caused by the bacterial necrotroph Erwinia carotovora or the necrotrophic fungus Alternaria brassicicola). RNA interference silencing of AtCLH1 resulted in failure to degrade free chlorophyll after tissue damage and in resistance to E. carotovora. Both inoculation with E. carotovora and exposure to high light caused elevated accumulation of hydrogen peroxide in AtCLH1 silenced plants. This was accompanied by expression of marker genes for systemic acquired resistance and induction of antioxidant defenses. Interestingly, downregulation of AtCLH1 resulted in increased susceptibility to A. brassicicola, resistance to which requires jasmonate signaling. We propose that AtCLH1 is involved in plant damage control and can modulate the balance between different plant defense pathways.
Correction to “Self‐consistent modeling of equatorial dawn density depletions with SAMI3”

[1] In the paper “Self‐consistent modeling of equatorial dawn density depletions with SAMI3” by Huba et al. (Geophysical Research Letters, 37, L03104, doi:10.1029/ 2009GL041492, 2010) it was found that the development of an eastward electric field in the post‐midnight/pre‐dawn equatorial ionosphere is responsible for the dawn density depletions [de La Beaujardière et al., 2009]. This electric field generates an upward drift of the plasma that lifts low density plasma to higher altitudes. This result was based on the NRL ionosphere model SAMI3 [Huba et al., 2008] and the empirical neutral wind model HWM07 [Drob et al., 2008]. However, the results are not accurate because of an incorrect input parameter that led to a miscalculation of the ionospheric conductances. The species N and N2 + were inadvertently neglected in the original calculation. [2] We show examples of the corrected results and compare them to the reported results. In Figure 1 we show contour plots of the electron density as a function of altitude and local time at the magnetic equator and longitude 292°. Figure 1 (top) is the original result and Figure 2 (bottom) is the new result. The corrected result still shows a post‐midnight upward drift albeit at a lower value than the original result. Additionally, there is a slightly stronger downward drift that is a maximum prior to sunrise in the new calculation. We find that the pre‐dawn downward drift is much stronger at other
Iterative Scheduling Algorithms

The input-queued switch architecture is widely used in Internet routers due to its ability to run at very high line speeds. A central problem in designing an input-queued switch is the scheduling algorithm that decides which packets to transfer from ingress ports to egress ports in a given timeslot. It is desirable that such algorithms be iterative (so as to be pipelineable), distributed (allowing flexibility in hardware implementation) and are able to deliver high performance (in terms of throughput and delay). In practice, implementable algorithms have so far had limited success in combining all of the above properties. For example, the popular iSLIP algorithm is known to perform suboptimally, but it is commercially deployed mainly because it is iterative and distributed. The main contribution of this paper is the design and systematic analysis of two algorithms which, to the best of our knowledge, are the first high-performance iterative and distributed scheduling algorithms with possibility of efficient implementation. We first present an iterative, distributed and low-delay maximal throughput algorithm based on the celebrated "auction algorithm". This algorithm can be seen as a natural extension of iSLIP when queue-size information is allowed to be exchanged. The standard auction algorithm can take an unbounded number of iterations to converge in the worst case. However we show that under admissible Bernoulli i.i. d. traffic, our algorithm takes O(n2) iterations, where n is the number of ingress/egress ports in the switch. Moreover for a switch with finite buffer-size, the algorithm allows for a graceful trade-off between running time and performance, which we verify by representative simulation results. Next, we propose and analyze a throughput-optimal, iterative and distributed scheduling algorithm influenced by Max-product belief propagation. Recently the problem of efficient transmission over multi-hop wireless networks has been formulated as that of finding an appropriate schedule over the grid-graph abstraction of the network. A key feature of the multi-hop wireless transmission problem is that while the communication subgraph is bipartite, the bi-partition is allowed to change in each scheduling epoch. We show that our algorithm can be used to efficiently schedule traffic in multi-hop wireless networks.
Variants in the Dihydropyrimidine Dehydrogenase, Methylenetetrahydrofolate Reductase and Thymidylate Synthase Genes Predict Early Toxicity of 5-Fluorouracil in Colorectal Cancer Patients

Adverse drug reactions to 5-fluorouracil (5-FU)-based chemotherapy have been reported to be due, in part, to genetic variants of the genes for the drug-related enzymes thymidylate synthase (TS; TYMS gene), methylenetetrahydrofolate reductase (MTHFR gene) and dihydropyrimidine dehydrogenase (DPD; DPYD gene). This study investigated whether selected genetic variants of the TYMS, MTHFR and DPYD genes predict 5-FU-related early toxicity. The prevalence of the genetic variants was determined in 122 colorectal cancer patients and in a reference population of 320 blood donors. Subgroup analysis of 68 of the colorectal cancer patients was carried out to determine the relationship between selected gene variants detected in peripheral mononuclear cells and tolerability during the first or second cycle of 5-FU based treatment. Toxicity was linked to the TYMS 2R/2R variant (relative risk [RR] 1.66; sensitivity 0.37; specificity 0.77) and to the MTHFR c1298 C/C genetic variant (RR 1.77; sensitivity 0.17; specificity 0.91). Patients with the genetic variant IVS14+1 G/A or c1896 C/T in the DPYD gene had a statistically significant increased risk of experiencing toxicity (RR 2 and 6, respectively), both having a high specificity (0.97 and 0.98, respectively) and low sensitivity (0.04 and 0.13, respectively). It is concluded that pre-treatment detection of genetic variants can help to predict early toxicity experienced by patients receiving 5-FU-based chemotherapy.
Perception and reproduction of force direction in the horizontal plane.

In this study, we evaluated the capacity of human beings to perceive and reproduce forces applied to the hand. We tested for perceptive distortions and/or privileged directions in the performance of these two tasks. Subjects resisted a reference force applied by a joystick in a given direction, with instructions to keep the hand at a constant position. In a perception task, subjects subsequently resisted a second such force, the direction of which they could adjust with a potentiometer; the task was to reorient the second force to be in the same perceived direction as the reference. In a reproduction task, subjects were instructed to push against the now elastically constrained joystick with the same force that was required to resist the initially applied reference force. Twenty-four reference force directions in the horizontal plane were tested twice each. We observed systematic distortions in the reproduction of force direction that were not present in the perception task. We further observed that the distortions could be predicted by anisotropy of limb stiffness and could be affected by manipulating the mechanical impedance of the hand-joystick interaction. We conclude that human subjects specify and store forces to be applied by the hand not in terms of a perceived force vector, but rather in terms of the motor activity required to resist or produce the force-i.e., subjects possess a multi-dimensional "sense of effort. "
Remote Ischemic Preconditioning Applied during Isoflurane Inhalation Provides No Benefit to the Myocardium of Patients Undergoing On-pump Coronary Artery Bypass Graft Surgery: Lack of Synergy or Evidence of Antagonism in Cardioprotection?

Background: Two preconditioning stimuli should induce a more consistent overall cell protection. We hypothesized that remote ischemic preconditioning (RIPC, second preconditioning stimulus) applied during isoflurane inhalation (first preconditioning stimulus) would provide more protection to the myocardium of patients undergoing on-pump coronary artery bypass grafting. Methods: In this placebo-controlled randomized controlled study, patients in the RIPC group received four 5-min cycles of 300 mmHg cuff inflation/deflation of the leg before aortic cross-clamping. Anesthesia consisted of opioids and propofol for induction and isoflurane for maintenance. The primary outcome was high-sensitivity cardiac troponin T release. Secondary endpoints were plasma levels of N-terminal pro-brain natriuretic peptide, high-sensitivity C-reactive protein, S100 protein, and short- and long-term clinical outcomes. Gene expression profiles were obtained from atrial tissue using microarrays. Results: RIPC (n = 27) did not reduce high-sensitivity cardiac troponin T release when compared with placebo (n = 28). Likewise, N-terminal pro-brain natriuretic peptide, a marker of myocardial dysfunction; high-sensitivity C-reactive protein, a marker of perioperative inflammatory response; and S100, a marker of cerebral injury, were not different between the groups. The incidence for the perioperative composite endpoint combining new arrhythmias and myocardial infarctions was higher in the RIPC group than the placebo group (14/27 vs. 6/28, P = 0.036). However, there was no difference in the 6-month cardiovascular outcome. N-terminal pro-brain natriuretic peptide release correlated with isoflurane-induced transcriptional changes in fatty-acid metabolism (P = 0.001) and DNA-damage signaling (P < 0.001), but not with RIPC-induced changes in gene expression. Conclusions: RIPC applied during isoflurane inhalation provides no benefit to the myocardium of patients undergoing on-pump coronary artery bypass grafting.
Metabolic engineering of Bacillus subtilis for production of D‐lactic acid

Poly lactic acid (PLA) based plastics is renewable, bio‐based, and biodegradable. Although present day PLA is composed of mainly L‐LA, an L‐ and D‐ LA copolymer is expected to improve the quality of PLA and expand its use. To increase the number of thermotolerant microbial biocatalysts that produce D‐LA, a derivative of Bacillus subtilis strain 168 that grows at 50°C was metabolically engineered. Since B. subtilis lacks a gene encoding D‐lactate dehydrogenase (ldhA), five heterologous ldhA genes (B. coagulans ldhA and gldA101, and ldhA from three Lactobacillus delbrueckii) were evaluated. Corresponding D‐LDHs were purified and biochemically characterized. Among these, D‐LDH from L. delbrueckii subspecies bulgaricus supported the highest D‐LA titer (about 1M) and productivity (2 g h−1 g cells−1) at 37°C (B. subtilis strain DA12). The D‐LA titer at 48°C was about 0.6 M at a yield of 0.99 (g D‐LA g−1glucose consumed). Strain DA12 also fermented glucose at 48°C in mineral salts medium to lactate at a yield of 0.89 g g−1 glucose and the D‐lactate titer was 180 ± 4.5 mM. These results demonstrate the potential of B. subtilis as a platform organism for metabolic engineering for production of chemicals at 48°C that could minimize process cost.
Cyclic behaviour and liquefaction resistance of Izumio sands in Osaka, Japan

Abstract This article presents a study of liquefaction resistance behaviour of sand using a cyclic triaxial test. The site investigation was performed, and frozen undisturbed specimens were taken from the Izumio site in Osaka, Japan. According to the evidence in 1995 Kobe Earthquake, the first two sand layers are vulnerable to undergo liquefaction. The effect of deviatoric stress on liquefaction resistance was focused on in this study. The excess pore pressure ratio, hysteresis loop, and effective stress path from the cyclic triaxial tests were reported. A multispring element model was employed to simulate the soil behaviour under cyclic loading. The results showed that applied deviatoric stress could influence the liquefaction resistance of sandy soil samples. The plots of the cyclic stress ratio versus the number of cycles to generate liquefaction known as a liquefaction resistance curve can be then constructed and compared with other sands.
A study on the scalability of non-preferred hand mode manipulation

In pen-tablet input devices modes allow overloading of the electronic stylus. In the case of two modes, switching modes with the non-preferred hand is most effective [12]. Further, allowing temporal overlap of mode switch and pen action boosts speed [11]. We examine the effect of increasing the number of interface modes accessible via non-preferred hand mode switching on task performance in pen-tablet interfaces. We demonstrate that the temporal benefit of overlapping mode-selection and pen action for the two mode case is preserved as the number of modes increases. This benefit is the result of both concurrent action of the hands, and reduced planning time for the overall task. Finally, while allowing bimanual overlap is still faster it takes longer to switch modes as the number of modes increases. Improved understanding of the temporal costs presented assists in the design of pen-tablet interfaces with larger sets of interface modes.
The relationship between individual creativity and team creativity: aggregating across people and time

Summary This paper investigates how the creativity of individual team members is related to team creativity, and the influence of climate for creativity in the workplace on individual and team creativity. A multilevel theoretical model is proposed, and the authors report a study which tests the model using a sample of 54 research and development teams. The results showed that team creativity scores could be explained statistically by aggregation processes across both people and time. Team creativity at a particular point in time could be explained as either the average or a weighted average of team member creativity; the creativity of project outcomes was explained by either the maximum of or average of team creativity across time-points. According to the model, failure to account for aggregation across time as well as across individuals can result in misleading empirical results, and can result in the erroneous conclusion that team climate influences team creativity directly rather than indirectly via individuals. Copyright # 2004 John Wiley & Sons, Ltd.
Selection of cancer chemotherapy for a patient by an in vitro assay versus a clinician.

One hundred thirty-three patients with advanced metastatic cancer were randomized to receive single-agent chemotherapy selected by either a medical oncologist or an in vitro capillary cloning system. Thirty-six of the 65 patients (55%) who were randomly assigned to selection of a drug by the clinician actually received a drug; these patients were able to be evaluated for clinical response. Of these 36 patients, one had a partial tumor response (3%). Only 19 of the 68 patients (28%) who were randomly assigned to selection of a drug by the capillary system actually received a drug; these patients were able to be evaluated for clinical response. Of these 19 patients, four (21%) had partial tumor responses. In the assessable patients (36 in the clinician's choice group, 19 in the capillary cloning group), the partial response rate was superior for drug selection by the capillary cloning system (P = .04). For all patients randomly assigned to a group (65 in the clinician's choice group, 68 in the capillary cloning group), the response rate was not significantly different (1.5% and 5.9%, respectively; P = .37). When overall survival rates for patients in the two groups were compared, there was no difference. We conclude that drug sensitivity testing in capillary tubes can improve the response rate for patients with advanced malignancies. This improved response rate, however, does not translate into improved survival times for these patients.
Play and Rewind: Optimizing Binary Representations of Videos by Self-Supervised Temporal Hashing

We focus on hashing videos into short binary codes for efficient Content-based Video Retrieval (CBVR), which is a fundamental technique that supports access to the ever-growing abundance of videos on the Web. Existing video hash functions are built on three isolated stages: frame pooling, relaxed learning, and binarization, which have not adequately explored the temporal order of video frames in a joint binary optimization model, resulting in severe information loss. In this paper, we propose a novel unsupervised video hashing framework called Self-Supervised Temporal Hashing (SSTH) that is able to capture the temporal nature of videos in an end-to-end learning-to-hash fashion. Specifically, the hash function of SSTH is an encoder RNN equipped with the proposed Binary LSTM (BLSTM) that generates binary codes for videos. The hash function is learned in a self-supervised fashion, where a decoder RNN is proposed to reconstruct the original video frames in both forward and reverse orders. For binary code optimization, we develop a backpropagation rule that tackles the non-differentiability of BLSTM. This rule allows efficient deep network training without suffering from the binarization loss. Through extensive CBVR experiments on two real-world consumer video datasets of Youtube and Flickr, we show that SSTH consistently outperforms state-of-the-art video hashing methods, eg. , in terms of mAP@20, SSTH using only 128 bits can still outperform others using 256 bits by at least 9% to 15% on both datasets.
Post‐operative smoking status in lung and head and neck cancer patients: association with depressive symptomatology, pain, and fatigue

An estimated 35–50% of lung and head and neck cancer patients are smoking at diagnosis; most try to quit; however, a substantial proportion resumes smoking. As cancer treatments improve, attention to the effects of continued smoking on quality of life in the survivorship period is increasing. The current study examines if smoking abstinence following surgical treatment is associated with better quality of life.