Miracle-dz/UniFAR-FTUs huggingface dataset:
Stages and Levels of Automation in Support of Space Teleoperations

Objective: This study examined the impact of stage of automation on the performance and perceived workload during simulated robotic arm control tasks in routine and off-nominal scenarios. Background: Automation varies with respect to the stage of information processing it supports and its assigned level of automation. Making appropriate choices in terms of stages and levels of automation is critical to ensure robust joint system performance. To date, this issue has been empirically studied in domains such as aviation and medicine but not extensively in the context of space operations. Method: A total of 36 participants played the role of a payload specialist and controlled a simulated robotic arm. Participants performed fly-to tasks with two types of automation (camera recommendation and trajectory control automation) of varying stage. Tasks were performed during routine scenarios and in scenarios in which either the trajectory control automation or a hazard avoidance automation failed. Results: Increasing the stage of automation progressively improved performance and lowered workload when the automation was reliable, but incurred severe performance costs when the system failed. Conclusion: The results from this study support concerns about automation-induced complacency and automation bias when later stages of automation are introduced. The benefits of such automation are offset by the risk of catastrophic outcomes when system failures go unnoticed or become difficult to recover from. Application: A medium stage of automation seems preferable as it provides sufficient support during routine operations and helps avoid potentially catastrophic outcomes in circumstances when the automation fails.
Multifunctional In Situ Photopolymerized Semi-Interpenetrating Network System is an Effective Donor Site Dressing: A Cross Comparison Study in a Swine Model

Effective dressings for donor sites or other partial thickness wounds must promote removal of nonviable or necrotic tissue, eradication and prevention of microbial infiltrate, exudate absorbance, and regrowth of healthy epidermis and dermis. There are many commonly used products that facilitate these processes. Established properties of an in situ photopolymerizable semi-interpenetrating network (sIPN) suggest that it is also a viable treatment option. The widely varying material properties suggest that these dressing treatments may elicit different healing responses via different cellular mechanisms. In this study, we sought to resolve the differences in healing between ActicoatTM, sIPN, nonadherent dressing with TisseelTM, and XeroformTM dressing treatments in a porcine partial thickness wound model. Donor site wounds were produced on pigs at two cut depths and dressed with ActicoatTM, sIPN, nonadherent dressing with TisseelTM, and XeroformTM with alternatively placed autografts to provide a control area between each test site. Pigs were euthanized at 4, 7, 14, and 42 days for macroscopic examination and biopsy collection. Biopsies were analyzed histologically by two blinded observers for cellular densities and regional thicknesses within the tissue. sIPN- and XeroformTM-treated wounds were healed by 7 days, and ActicoatTM– and nonadherent dressing with TisseelTM–treated wounds were healed by 14 days. Inflammatory responses were between comparable treatment type across all time periods. Dermal granulation features increased with time but were not significantly different. All dressing treatments elicited wound healing without outstanding toxicity or pathology indicating that sIPN is a comparable and viable treatment for partial thickness wounds.
Hepatoprotective and Antioxidant Effects of Saponarin, Isolated from Gypsophila trichotoma Wend. on Paracetamol-Induced Liver Damage in Rats

The hepatoprotective potential of saponarin, isolated from Gypsophila trichotoma, was evaluated in vitro/in vivo using a hepatotoxicity model of paracetamol-induced liver injury. In freshly isolated rat hepatocytes, paracetamol (100 μmol) led to a significant decrease in cell viability, increased LDH leakage, decreased levels of cellular GSH, and elevated MDA quantity. Saponarin (60–0.006 μg/mL) preincubation, however, significantly ameliorated paracetamol-induced hepatotoxicity in a concentration-dependent manner. The beneficial effect of saponarin was also observed in vivo. Rats were challenged with paracetamol alone (600 mg/kg, i.p.) and after 7-day pretreatment with saponarin (80 mg/kg, oral gavage). Paracetamol toxicity was evidenced by increase in MDA quantity and decrease in cell GSH levels and antioxidant defence system. No changes in phase I enzyme activities of AH and EMND and cytochrome P 450 quantity were detected. Saponarin pretreatment resulted in significant increase in cell antioxidant defence system and GSH levels and decrease in lipid peroxidation. The biochemical changes are in good correlation with the histopathological data. Protective activity of saponarin was similar to the activity of positive control silymarin. On the basis of these results, it can be concluded that saponarin exerts antioxidant and hepatoprotective activity against paracetamol liver injury in vitro/in vivo.
The Development Of Differential Object Marking In Spanish-English Bilingual Children

Ortiz Vergara. Mariluz M.A., Purdue University, May 2013. The Development of Differential Object Marking in Spanish-English Bilingual Children. Major Professor: Alejandro Cuza-Blanco. In monolingual development, the acquisition of differential object marking (DOM) is completed by three years of age (RodriguezMondonedo, 2008). However, among bilingual speakers, the development and use of the marker at a young age is less predictable. Spanish marks animate and specific direct objects with the preposition-a; English in contrast does not. Based on previous studies documenting transfer in areas where Spanish and English differ, it was predicted that bilingual children would experience difficulties with the use of the preposition both in matrix and left dislocated sentences (CLLD) (Montrul, 2004, Montrul & Bowles, 2009). This study tested 14 simultaneous Spanish-English bilingual children divided into a younger (6;04-7;09) and an older group (8;06-10;10) as part of a larger study. Six parents participated as a baseline to control for the possible acquisition of a variety in which the personal-a is not used (Rothman, 2007). The use of DOM was elicited in animate and inanimate specific contexts through a question and answer task for matrix sentences (Thornton, 1990) and a sentence completion task for CLLD sentences (e.g., Cuza, Perez-Leroux & Sanchez, 2012). The results show that older children have some knowledge of
Stability analysis and design of momentum-based controllers for humanoid robots

Envisioned applications for humanoid robots call for the design of balancing and walking controllers. While promising results have been recently achieved, robust and reliable controllers are still a challenge for the control community dealing with humanoid robotics. Momentum-based strategies have proven their effectiveness for controlling humanoids balancing, but the stability analysis of these controllers is still missing. The contribution of this paper is twofold. First, we numerically show that the application of state-of-the-art momentum-based control strategies may lead to unstable zero dynamics. Secondly, we propose simple modifications to the control architecture that avoid instabilities at the zero-dynamics level. Asymptotic stability of the closed loop system is shown by means of a Lyapunov analysis on the linearized system's joint space. The theoretical results are validated with both simulations and experiments on the iCub humanoid robot.
Tracheal intubating conditions after induction with propofol, remifentanil and lignocaine.

We have studied the intubating conditions in 60 ASA I or II patients, after induction of anaesthesia with propofol 2 mg kg-1, allocated to one of the following three groups: group 1, remifentanil 1 microgram kg-1; group 2, remifentanil 1 microgram kg-1 and lignocaine 1 mg kg-1; group 3, remifentanil 2 micrograms kg-1. No neuromuscular blocking agents were administered. Intubating conditions were assessed using a four-point scoring system based on ease of laryngoscopy, jaw relaxation, position of vocal cords, degree of coughing and limb movement. Overall intubating conditions were acceptable in 35% of patients in group 1, 100% of patients in group 2 and 85% of patients in group 3. There was a statistically significant drop in blood pressure after induction in groups 2 and 3, and two patients in each group required ephedrine 6 mg i.v. boluses, as dictated by the intervention criteria (mean arterial pressure fall > 25% from baseline). Similarly, there was a drop in heart rate in groups 2 and 3, but this did not reach statistical or clinical significance, and no patient required atropine.
Mining Internet-Scale Software Repositories

Large repositories of source code create new challenges and opportunities for statistical machine learning. Here we first develop Sourcerer, an infrastructure for the automated crawling, parsing, and database storage of open source software. Sourcerer allows us to gather Internet-scale source code. For instance, in one experiment, we gather 4,632 java projects from SourceForge and Apache totaling over 38 million lines of code from 9,250 developers. Simple statistical analyses of the data first reveal robust power-law behavior for package, SLOC, and lexical containment distributions. We then develop and apply unsupervised author-topic, probabilistic models to automatically discover the topics embedded in the code and extract topic-word and author-topic distributions. In addition to serving as a convenient summary for program function and developer activities, these and other related distributions provide a statistical and information-theoretic basis for quantifying and analyzing developer similarity and competence, topic scattering, and document tangling, with direct applications to software engineering. Finally, by combining software textual content with structural information captured by our CodeRank approach, we are able to significantly improve software retrieval performance, increasing the AUC metric to 0.84- roughly 10-30% better than previous approaches based on text alone. Supplementary material may be found at: http://sourcerer.ics. uci.edu/nips2007/nips07.html.
Viral Etiologies of Infant Bronchiolitis, Croup and Upper Respiratory Illness During 4 Consecutive Years

Background: Prospective data on viral etiology and clinical characteristics of bronchiolitis and upper respiratory illness (URI) in infants are limited. Methods: This prospective cohort enrolled previously healthy term infants during inpatient or outpatient visits for acute URI or bronchiolitis during September to May 2004 to 2008. Illness severity was determined using an ordinal bronchiolitis severity score. Common respiratory viruses were identified by real-time reverse-transcriptase polymerase chain reaction. Results: Of 648 infants, 67% were enrolled during inpatient visits and 33% during outpatient visits. Seventy percent had bronchiolitis, 3% croup and 27% URI. Among infants with bronchiolitis, 76% had respiratory syncytial virus (RSV), 18% human rhinovirus (HRV), 10% influenza, 2% coronavirus, 3% human metapneumovirus and 1% parainfluenza virus. Among infants with croup, 39% had HRV, 28% parainfluenza virus, 28% RSV, 11% influenza, 6% coronavirus and none human metapneumovirus. Among infants with URI, 46% had HRV, 14% RSV, 12% influenza, 7% coronavirus, 6% parainfluenza virus and 4% human metapneumovirus. Individual viruses exhibited distinct seasonal, demographic and clinical expression. Conclusions: The most common infections among infants seeking care in unscheduled medical visits for URI or bronchiolitis were RSV and HRV. Demographic differences were observed between patients with different viruses, suggesting that host and viral factors play a role in phenotypic expression of viral illness.
In vitro influence of stem surface finish and mantle conformity on pressure generation in cemented hip arthroplasty

Background and purpose Under physiological loads, debonded cemented femoral stems have been shown to move within their cement mantle and generate a fluid pump that may facilitate peri-prosthetic osteolysis by pressurizing fluid and circulating wear debris. The long-term physiological loading of rough and polished tapered stems in vitro has shown differences in performance, with greater interface pressures generated by the rough stems. In this study we investigated the individual effects of stem surface finish, degree of mantle wear, and mode of loading on the stem pump mechanism. Method Rough and polished stems were loaded under different regimes in artificially worn cement mantles that permitted either 2 or 5 degrees of rotational stem movement, and the interface pressures were compared. Results The pressures generated by the rough and polished stems were similar in either type of mantle. The pattern of pressure generation in the 2-degree mantles was similar to the pressures generated by rough stems after long-term loading, but the high posterior wall pressures fell and the tip pressures increased in the 5-degree mantles. The torsional loads were principal drivers of pressure generation in all areas of the interface other than the implant tip, where axial loading predominated. Interpretation Femoral stems with rotational instability under cyclic torsional loads generate elevated interface fluid pressures and flows independently of stem surface finish. The rough surface finish is only important in creating this instability in tapered stems.
Gender, Internet Identification, and Internet Anxiety: Correlates of Internet Use

This paper reports a study that investigated the effects of gender, Internet anxiety, and Internet identification on use of the Internet. The study involved 608 undergraduate students (490 females and 118 males). We surveyed the students' experience with the Internet, as well as their levels of Internet anxiety and Internet identification. We found a number of gender differences in participants' use of the Internet. Males were proportionally more likely to have their own web page than were females. They used the Internet more than females; in particular, they were more likely to use game websites, to use other specialist websites, and to download material from the Internet. However, females did not use the Internet for communication more than males. There was a significant positive relationship between Internet identification and total use of the Internet, and a significant negative relationship between Internet anxiety and total use of the Internet. Controlling for Internet identification and Internet anxiety, we found a significant and negative correlation between gender and use of the Internet. In total, all three of our predictors accounted for 40% of the variance in general Internet use: with Internet identification accounting for 26%, Internet anxiety accounting for 11%, and gender accounting for 3%.
Anticapsid Immunity Level, Not Viral Persistence Level, Correlates with the Progression of Theiler's Virus-Induced Demyelinating Disease in Viral P1-Transgenic Mice

ABSTRACT Intracranial infection of Theiler's murine encephalomyelitis virus (TMEV) induces demyelination and a neurological disease in susceptible SJL/J (SJL) mice that resembles multiple sclerosis. While the virus is cleared from the central nervous system (CNS) of resistant C57BL/6 (B6) mice, it persists in SJL mice. To investigate the role of viral persistence and its accompanying immune responses in the development of demyelinating disease, transgenic mice expressing the P1 region of the TMEV genome (P1-Tg) were employed. Interestingly, P1-Tg mice with the B6 background showed severe reductions in both CD4+ and CD8+ T-cell responses to capsid epitopes, while P1-Tg mice with the SJL background displayed transient reductions following viral infection. Reduced antiviral immune responses in P1-Tg mice led to >100- to 1,000-fold increases in viral persistence at 120 days postinfection in the CNS of mice with both backgrounds. Despite the increased CNS TMEV levels in these P1-Tg mice, B6 P1-Tg mice developed neither neuropathological symptoms nor demyelinating lesions, and SJL P1-Tg mice developed significantly less severe TMEV-induced demyelinating disease. These results strongly suggest that viral persistence alone is not sufficient to induce disease and that the level of T-cell immunity to viral capsid epitopes is critical for the development of demyelinating disease in SJL mice.
A comparison of strain and fluid shear stress in stimulating bone cell responses—a computational and experimental study

Bone undergoes continuous remodeling in response to mechanical loading. However, the underlying mechanisms by which bone cells respond to their changing mechanical environment, that is, strain in the load‐bearing matrix or fluid flow through the canalicular network, are not well understood. It has been established in vitro that bone cells respond differently to substrate strain and fluid shear stress treatments. Uncovering the mechanical basis of these differences represents a significant challenge to our understanding of cellular mechanotransduction and bone remodeling. To investigate this problem, we developed a biomechanical model of an adherent cell, to test the hypothesis that bone cells respond differently to 0.6 Pa fluid shear stress and 1,000 µε substrate strain stimulation because of qualitative and quantitative differences in the cellular deformation caused. Fluid shear stress loading conditions resulted in maximum displacements at the apical surface of the cell ∼8 times higher than those due to strain at the cellsubstrate interface and also caused higher stressing of all parts of the cell. Significantly, this shows that the deforming effects of fluid shear stress and strain on a cellular level are qualitatively different, which may provide a basis for explaining differences in bone cell responses to both stimuli as reported in several studies. Although our approach to modeling the morphology and complex physical environment of an adherent cell is certainly simplified, our results do show independent roles for fluid flow and strain as mechanical stimuli and highlight the importance of deformation on a cellular level in bone physiology.
The postcentral sulcal complex and the transverse postcentral sulcus and their relation to sensorimotor functional organization

It has been demonstrated that the postcentral sulcus, which forms the posterior boundary of the sensorimotor region, is a complex of distinct sulcal segments. Although the general somatotopic arrangement in the human sensorimotor cortex is relatively well known, we do not know whether the different segments of the postcentral sulcus relate in a systematic way to the sensorimotor functional representations. Participants were scanned with functional magnetic resonance imaging while they made movements of different body parts and the location of functional activity was examined on a subject‐by‐subject basis with respect to the morphological features of the postcentral sulcus. The findings demonstrate that the postcentral sulcus of each subject may be divided into five segments and there is a tight relationship between sensorimotor representations of different body parts and specific segments of the postcentral sulcus. The results also addressed the issue of the transverse postcentral sulcus, a short sulcus that is present within the ventral part of the postcentral gyrus in some brains. It was shown that, when present, this sulcus is functionally related to the oral (mouth and tongue) sensorimotor representation. When this sulcus is not present, the inferior postcentral sulcus which is also related to the oral representation is longer. Thus, the sulcal morphology provides an improved framework for functional assignments in individual subjects.
Exploring salutogenic mechanisms of an outdoor experiential learning programme on youth care farms in the Netherlands: untapped potential?

This study explored how (learning) experiences offered through outdoor experiential programmes, particularly the youth care farm approach, may (or may not) enhance young peoples' ability to recognise and then utilise available resources for personal growth, protection and health promotion. A total of 11 youngsters were asked to look back on their half-year stay on a care farm in the Netherlands, by using semi-structured interviews to elicit their experiences from a salutogenic perspective. Analysis revealed that several resources (and the interaction of these resources) on the youth care farm worked well for the youngsters; contributed to their personal development and to their sense of coherence: the feeling that the world is or can be meaningful, comprehensible and manageable, associated with positive outcome in endeavours linked to improving health and well-being. In general, the attitude of the farmer, working with animals, the informal atmosphere and being temporarily cut-off from the former environment were elements most positively highlighted by the youngsters. The farm environment was mentioned as calming, however, as structuring as well. The strength of the programme as an experiential learning opportunity appears to be the diversity and richness of resources (and stressors! ) available to the participants. This creates various opportunities for learning: making sense, interpreting and giving meaning to resources and stressors. Further research into the impact of this kind of programmes, compared to more ‘traditional’ programmes, especially on the ability of youngsters to use resources to finish school, find employment and develop better relationships with their parents is recommended.
Search Improves Label for Active Learning

We investigate active learning with access to two distinct oracles: Label (which is standard) and Search (which is not). The Search oracle models the situation where a human searches a database to seed or counterexample an existing solution. Search is stronger than Label while being natural to implement in many situations. We show that an algorithm using both oracles can provide exponentially large problem-dependent improvements over Label alone.
Cervico-Cephalic Arterial Thrombi and Thromboemboli in Moyamoya Disease - Possible Correlation With Progressive Intimal Thickening in the Intracranial Major Arteries

Ninety-two thrombi and/or thromboemboli of cervico-cephalic arteries were confirmed histopathologically in 16 out of 22 patients with moyamoya disease. Included were 74 white thrombi mainly composed of fibrin and platelets, 9 organized thrombi and 9 mixed thrombi containing red blood cells. Thirteen microthrombi and one organized thrombus were located in the cervical arteries. Seventy-eight thrombi were present in the intracranial major arteries. Sixty-five were white microthrombi attached to the luminal surface of the arteries. The intracranial microthrombi were most frequently observed at the distal ends of the internal carotid arteries (29 thrombi). The fibrous thickening of the inlima and edema in the innermost luminal surface were the most common vascular alterations associated with the thrombus formation. In two patients, thrombus formation was associated with fissure of the thickened intima and a dissecting aneurysm. We concluded that in patients with moyamoya disease the thrombi may be closely related to the development of intimal thickening in the intracranial arteries, particularly at the distal ends of the internal carotid arteries. Stroke Vol 15. No 2. 1984