Miracle-dz/UniFAR-FTUs huggingface dataset:
A comparative study on the efficacy of dexmedetomidine and tramadol on post-spinal anesthesia shivering

Background: Shivering is a common postanesthesia adverse event with multiple etiologies. At present tramadol is a widely used drug for the control of shivering. However, tramadol may cause a lot of nausea and vomiting. Hence, the need to find a better drug with less of side effects. The aim of this study was to compare the efficacy of dexmedetomidine and tramadol in the treatment of post-spinal anesthesia (SA) shivering as well as to compare their side-effect profile. Materials and Methods: This prospective, double-blind, randomized controlled trial was conducted in a tertiary care hospital. A total of 100 patients having shivering after SA were enrolled, out of which fifty received dexmedetomidine (Group A) and 50 received tramadol (Group B). The response rate, time to cessation of shivering and side effects (if any) was noted. All the results were analyzed using Student's t-test and Chi-square test. Results: All patients who received dexmedetomidine as well as tramadol had cessation of shivering. The time to cessation of shivering was significantly less with dexmedetomidine (174.12 ± 14.366 s) than with tramadol (277.06 ± 23.374 s) (P < 0.001). The recurrence rate of shivering with dexmedetomidine was less (6%) as compared to tramadol (16%). Nausea and vomiting was found to be higher in the case of tramadol. On the other hand, dexmedetomidine caused moderate sedation (modified Ramsay sedation score = 3–4) from which the patient could be easily awoken up. Conclusion: Dexmedetomidine offers better results than tramadol with fewer side effects.
Pathological game use in adults with and without Autism Spectrum Disorder

This study tested whether adults with autism spectrum disorder (ASD) are at higher risk for pathological game use than typically developing (TD) adults. Participants included 119 adults with and without ASD. Participants completed measures assessing daily hours of video game use, percent of free time spent playing video games, and symptoms of pathological game use. The results indicated that adults with ASD endorsed more symptoms of video game pathology than did TD adults. This relationship was strong, enjoying 300,000-to-1 odds in Bayesian model comparison. Results also showed that adults with ASD spent more daily hours playing video games and spent a higher percent of their free time playing video games than did TD adults. Even after adjustment for these differences in daily video game hours and proportion of free time spent on games, model comparisons found evidence for a difference in game pathology scores associated with ASD status. Additionally, escapism motives for playing video games was associated with game pathology scores in both ASD and TD adults, replicating and extending a previous report. In conclusion, the risk for pathological game use appears larger in adults with ASD compared with TD adults. These findings point to pathological game use as a potentially important focus of clinical attention in adults with ASD.
A static type system for JVM access control

This article presents a static type system for the Java virtual machine (JVM) code that enforces an access control mechanism similar to that found in a Java implementation. In addition to verifying type consistency of a given JVM code, the type system statically verifies whether the code accesses only those resources that are granted by the prescribed access policy. The type system is proved to be sound with respect to an operational semantics that enforces access control dynamically, similar to Java stack inspection. This result ensures that “well-typed code cannot violate access policy. ” The authors then develop a type inference algorithm and show that it is sound with respect to the type system. These results allow us to develop a static system for JVM access control, without resorting to costly runtime stack inspection.
Portion and Independent of Sialylation or Arthritis in Mice Is Dependent on the Fc Therapeutic Effect of IVIG on Inflammatory

High-dose i.v. Ig (IVIG) is used to treat various autoimmune and inﬂammatory diseases; however, the mechanism of action remains unclear. Based on the K/BxN serum transfer arthritis model in mice, IVIG suppression of inﬂammation has been attributed to a mechanism involving basophils and the binding of highly sialylated IgG Fc to DC-SIGN–expressing myeloid cells. The requirement for sialylation was examined in the collagen Ab-induced arthritis (CAbIA) and K/BxN serum transfer arthritis models in mice. High-dose IVIG (1–2 g/kg body weight) suppressed inﬂammatory arthritis when given prophylactically. The same doses were also effective in the CAbIA model when given subsequent to disease induction. In this therapeutic CAbIA model, the antiinﬂammatory effect of IVIG was dependent on IgG Fc but not F(ab 9 ) 2 fragments. Removal of sialic acid residues by neuraminidase had no impact on the anti-inﬂammatory activity of IVIG or Fc fragments. Treatment of mice with basophil-depleting mAbs did not abrogate the suppression of either CAbIA or K/BxN arthritis by IVIG. Our data conﬁrm the therapeutic beneﬁt of IVIG and IgG Fc in Ab-induced arthritis but fail to support the signiﬁcance of sialylation and basophil involvement in the mechanism of action of IVIG therapy. The Journal of Immunology , 2014, 192: 000–000.
Face-Centered Central Composite Design for the Optimization of the Extraction of Phenolic Compounds from Kernels and Shells of Raphia farinifera and Evaluation of the Antioxidant, Antimicrobial, and Anti-Inflammatory Activities

This study reports the extraction of phenolic compound from shells and kernels of the Raphia farinifera fruit and the biological activities of the extract. A face-centered composite design was established to optimize the extraction conditions: ethanol/water ratio (0-100%), solvent/powder ratio (10-30 mL/g), and extraction time (90-180 min). Subsequently, the extracts obtained under the optimal conditions were used for the evaluation of the radical scavenging capacity, the capacity to chelate ferric ions, and the antimicrobial and anti-inflammatory activities. The optimal extraction conditions for the shells are an extraction time of 134.24 min, 65% ethanol in water, and a solvent/substrate ratio of 21.16 mL/g, and for the kernel, an extraction time of 180 min, 94.3% ethanol in water, and a solvent/substrate ratio of 18.6 mL/g. In these conditions, the phenolic compounds were 95.36 mg EAG/L for the shell extract and 139.72 mg EAG/L for the kernel extract. The antioxidant activity revealed that the half-maximal inhibitory concentrations (IC50) of the kernel extracts are 22.32 μg/mL and 55.73 μg/mL for the shells. A reducing activity of Fe 3+ ions with an activity of 308.39 μg EAA/mg for the kernel extracts and 293 μg EAA/mg for the shells was observed. B. cereus was the most sensitive microorganism with a minimum inhibitory concentration (MIC) equal to the minimum bactericidal concentration (MBC) with a value of 156.25 ppm for the kernel extract while the shell extract showed MIC of 625 ppm and MBC of 2500 ppm. The IC50 values for the denaturation of proteins by extracts of shells and kernels are 0.76 μg/mL and 0.56 μg/mL, respectively. Membrane stabilization revealed IC50 values of 1054.54 μg/mL and 1339 μg/mL for the shell and kernel extracts, respectively. This work has shown the potential of Raphia farinifera extracts for the food industry and cosmetics.
The phn Island: A New Genomic Island Encoding Catabolism of Polynuclear Aromatic Hydrocarbons

Bacteria are key in the biodegradation of polycyclic aromatic hydrocarbons (PAH), which are widespread environmental pollutants. At least six genotypes of PAH degraders are distinguishable via phylogenies of the ring-hydroxylating dioxygenase (RHD) that initiates bacterial PAH metabolism. A given RHD genotype can be possessed by a variety of bacterial genera, suggesting horizontal gene transfer (HGT) is an important process for dissemination of PAH-degrading genes. But, mechanisms of HGT for most RHD genotypes are unknown. Here, we report in silico and functional analyses of the phenanthrene-degrading bacterium Delftia sp. Cs1-4, a representative of the phnAFK2 RHD group. The phnAFK2 genotype predominates PAH degrader communities in some soils and sediments, but, until now, their genomic biology has not been explored. In the present study, genes for the entire phenanthrene catabolic pathway were discovered on a novel ca. 232 kb genomic island (GEI), now termed the phn island. This GEI had characteristics of an integrative and conjugative element with a mobilization/stabilization system similar to that of SXT/R391-type GEI. But, it could not be grouped with any known GEI, and was the first member of a new GEI class. The island also carried genes predicted to encode: synthesis of quorum sensing signal molecules, fatty acid/polyhydroxyalkanoate biosynthesis, a type IV secretory system, a PRTRC system, DNA mobilization functions and >50 hypothetical proteins. The 50% G + C content of the phn gene cluster differed significantly from the 66.7% G + C level of the island as a whole and the strain Cs1-4 chromosome, indicating a divergent phylogenetic origin for the phn genes. Collectively, these studies added new insights into the genetic elements affecting the PAH biodegradation capacity of microbial communities specifically, and the potential vehicles of HGT in general.
Building the Pamir‐Tibet Plateau—Crustal stacking, extensional collapse, and lateral extrusion in the Pamir: 3. Thermobarometry and petrochronology of deep Asian crust

Large domes of crystalline, middle to deep crustal rocks of Asian provenance make the Pamir a unique part of the India‐Asia collision. Combined major‐element and trace element thermobarometry, pseudosections, garnet‐zoning deconstruction, and geochronology are used to assess the burial and exhumation history of five of these domes. All domes were buried and heated sufficiently to initiate garnet growth at depths of 15–20 km at 37–27 Ma. The Central Pamir was then heated at ~10–20°C/Myr and buried at 1–2 km/Myr to 600–675°C at depths of 25–35 km by 22–19 Ma. The Shakhdara Dome in the South Pamir was heated at ~20°C/Myr and buried at 2–8 km/Myr to reach 750–800°C at depths of ≥50 km by ~20 Ma. All domes were exhumed at >3 km/Myr to 5–10 km depths and ~300°C by 17–15 Ma. The pressures, temperatures, burial rates, and heating rates are typical of continental collision. Decompression during exhumation outpaced cooling, compatible with tectonic unroofing along mapped large‐scale, normal‐sense shear zones, and with advection of near‐solidus or suprasolidus temperatures into the upper crust, triggering exhumation‐related magmatism. The Shakhdara Dome was exhumed from greater depth than the Central Pamir domes perhaps due to its position farther in the hinterland of the Paleogene retrowedge and to higher heat input following Indian slab breakoff. The large‐scale thickening and coincident ~20 Ma switch to extension throughout a huge area encompassing the Pamir and Karakorum strengthens the idea that the evolution of orogenic plateaux is governed by catastrophic plate‐scale events.
Impaired Gap Junction Formation and Intercellular Calcium Signaling in Urinary Bladder Cancer Cells can be Improved by Gö6976

Purpose: Calcium wave propagation and connexin 26, 32 and 43 expression were studied in normal and malignant urothelial cells. Materials and Methods: Human urothelial cell cultures were established from tissue biopsies obtained from three healthy control persons and compared to human transitional cell carcinoma (TCC) cell line 5637. Fluo-3 was used to study intercellular calcium signaling in urothelial cells. The cells were stimulated mechanically in the presence of inhibitors of gap-junctional or ATP-mediated communication to determine which pathways are operative in intercellular calcium signaling. In addition, Gö6976 was used to determine the effects of PKC α and βI inhibition on intercellular calcium signaling. Results: In normal urothelial cells, the primary pathway for intercellular calcium mediated cell signaling was gap junctional intercellular communication (GJIC), but the paracrine ATP-mediated signaling was also operative. In 5637 TCC cells, GJIC and ATP-mediated signaling routes were altered when compared to normal urothelial cells. More specifically, inhibition of GJIC resulted in a complete block of intercellular calcium signaling, while inhibition of ATP-mediated signaling decreased signal transduction in 5637 TCC cells. The results of the present study also demonstrated that connexin 26 was the most abundant gap junction plaque protein in cultured normal human urothelial cells and that it did not form gap junction plaques in 5637 TCC cell culture. Treatment with Gö6976 induced gap junction plaque formation by connexin 26 in 5637 TCC cells. In addition, the exposure to Gö6976 enhanced intercellular calcium mediated signaling in 5637 TCC cells, but not in normal cells. Conclusions: The results of the present study suggest that gap junctions play a major role in intercellular calcium signaling in urothelial cells. In addition, intercellular calcium signaling is altered in urinary bladder carcinoma cells, and it can be improved by PKC α and βI inhibition. (Supplementary materials are available for this article. Go to the publisher's online edition of Cell Communication and Adhesion for the following free supplemental resources; Movie files of normal Gö6976−, normal Gö6976+, TCC Gö6976−, TCC Gö6976+ and image of Supplementary ).
Tally NP Sets and Easy Census Functions

Abstract We study the question of whether every P set has an easy (i.e., polynomial-time computable) census function. We characterize this question in terms of unlikely collapses of language and function classes such as #P1⊆FP, where #P1 is the class of functions that count the witnesses for tally NP sets. We prove that every #P1PH function can be computed in FP#P1#P1. Consequently, every P set has an easy census function if and only if every set in the polynomial hierarchy does. We show that the assumption #P1⊆FP implies P=BPP and PH⊆MODk P for each k⩾2. We also relate a set's property of having an easy census function to other well-studied properties of sets, such as rankability and scalability (the closure of the rankable sets under P-isomorphisms). Finally, we prove that it is no more likely that the census function of any set in P can be approximated (more precisely, can be nα-enumerated in time nβ for fixed α and β) than that it can be precisely computed in polynomial time.
Kandoo: a framework for efficient and scalable offloading of control applications

Limiting the overhead of frequent events on the control plane is essential for realizing a scalable Software-Defined Network. One way of limiting this overhead is to process frequent events in the data plane. This requires modifying switches and comes at the cost of visibility in the control plane. Taking an alternative route, we propose Kandoo, a framework for preserving scalability without changing switches. Kandoo has two layers of controllers: (i) the bottom layer is a group of controllers with no interconnection, and no knowledge of the network-wide state, and (ii) the top layer is a logically centralized controller that maintains the network-wide state. Controllers at the bottom layer run only local control applications (i.e., applications that can function using the state of a single switch) near datapaths. These controllers handle most of the frequent events and effectively shield the top layer. Kandoo's design enables network operators to replicate local controllers on demand and relieve the load on the top layer, which is the only potential bottleneck in terms of scalability. Our evaluations show that a network controlled by Kandoo has an order of magnitude lower control channel consumption compared to normal OpenFlow networks.
Venous Thromboembolic Prophylaxis in Hospitalized Medical Patients

BACKGROUND: The risk for venous thromboembolism (VTE) in medical patients is similar to that in moderate-risk surgery patients. Pharmacologic thromboprophylaxis is recommended for certain medical patients, but its use in clinical practice is unknown. OBJECTIVE: To assess whether medically ill patients with established risk factors receive pharmacologic VTE prophylaxis and determine whether prescribed regimens are consistent with current evidence and published recommendations. METHODS: A retrospective chart review of 100 patients admitted to a hospital medicine service was conducted. Patients who were >40 years of age and admitted for congestive heart failure, chronic obstructive pulmonary disease, or respiratory infection were considered appropriate candidates for VTE prophylaxis if they had no documented bleeding risk factors. Patients considered at increased risk of bleeding included those with documented uncontrolled hypertension, thrombocytopenia, coagulopathy, or recent gastrointestinal bleeding. Prescribed regimens were evaluated to determine whether they were consistent with regimens proven in clinical trials to be effective and safe. RESULTS: Thirty-one percent of the patients with established VTE risk factors and no documented risk factors for bleeding were prescribed pharmacologic VTE prophylaxis. An established regimen was prescribed in only 19% of those receiving prophylaxis. CONCLUSIONS: There is significant underutilization of VTE prophylaxis in this patient population. Patients are not adequately assessed for bleeding risk factors, and a portion of prescribed regimens are not those that have been established in the literature. Expert consensus statements recommend that hospitals develop strategies to prevent VTE events in their patients. Strategies to improve patient screening and physicians' prescribing habits are needed.
Morphometry of the Supra Sciatic Notch Intrailiac Implant Anchor Passage

Study Design. Anatomic study of human ilia. Objective. To determine the anatomic dimensions influencing intrailiac anchor placement and design. Summary of Background Data. The development of the Galveston intrailiac implant anchor markedly improved results of spinal instrumentation to the pelvis. Better quantification of the passage dimensions is needed for the design of anatomically specific implants. Methods. The length and outer diameter of two intrailiac anchor passages were determined from randomly selected, disease-free pairs of ilia from 129 white skeletons belonging to the Hamann–Todd Osteological Collection (Cleveland, OH, Museum of Natural History). Results. Path B, an anchor passage running from the posterior superior iliac spine to the anterior inferior iliac spine, was significantly longer than path A, proceeding from the posterior superior iliac spine to the superior rim of the acetabulum, in adult and teenage males and females. For example, in adult females path B measured 141.2 ± 7.5 mm versus 124.9 ± 7.1 mm, P = <0.0001. The absolute minimum path A length available for an intrailiac post or screw anchor, following the required posterior superior iliac spine removal, was 80 mm in adults and male teenagers and 70 mm in female teenagers. For path B the hip joint was not at risk, and a safe anchor passage of at least 90 mm in teenagers and 110 mm in adults was available. The minimum thickness of the paths occurred directly above the sciatic notch. It was significantly larger in path A than path B, 20.2 ± 2.4 mm versus 14.4 ± 3.2 mm, P < 0.0001. Conclusion. Of the two supra sciatic intrailiac paths studied, the path passing from the posterior superior iliac spine toward the anterior inferior iliac spine provided a longer and potentially safer anchor site. These studies suggest techniques for accessing longer anchor paths and the need for larger diameter anchors in order to achieve optimum intra iliac anchor stiffness and strength.
Immunology for physicists

The immune system is a complex system of cells and molecules that can provide us with a basic defense against pathogenic organisms. Like the nervous system, the immune system performs pattern recognition tasks, learns, and retains a memory of the antigens that it has fought. The immune system contains more than 10{sup 7} different clones of cells that communicate via cell-cell contact and the secretion of molecules. Performing complex tasks such as learning and memory involves cooperation among large numbers of components of the immune system and hence there is interest in using methods and concepts from statistical physics. Furthermore, the immune response develops in time and the description of its time evolution is an interesting problem in dynamical systems. In this paper, the authors provide a brief introduction to the biology of the immune system and discuss a number of immunological problems in which the use of physical concepts and mathematical methods has increased our understanding. {copyright} {ital 1997} {ital The American Physical Society}
Restoration of Normal Ventricular Electrophysiology in Renovascular Hypertensive Rabbits after Treatment with Losartan

Left ventricular hypertrophy (LVH) is associated with abnormal ventricular electrophysiology. We have shown complete regression of LVH and normalization of ventricular electrophysiology in renovascular hypertensive rabbits treated with captopril. To determine if angiotensin II type 1 receptor (AT1) blockade produces the same benefit, we treated hypertensive rabbits with losartan for 3 months. LVH was evaluated by heart-to-body weight ratio (HW/BW). Vulnerability to ventricular arrhythmia was assessed by ventricular fibrillation threshold (VFT) and dispersion of effective refractory period (ERP). The electrical properties of single left ventricular myocytes were characterized by action potential duration at 90% repolarization (APD90) and inward rectifier K+ current (IK1) density. Hypertensive rabbits treated with vehicle (LVH/Vehicle) had higher mean arterial pressure (MAP, 81 ± 2 vs. 60 ± 2 mm Hg) and HW/BW (2.71 ± 0.07 vs. 1.97 ± 0.04 g/kg), lower VFT (20 ± 1 vs. 39 ± 2 mA), larger dispersion of ERP (34 ± 3 vs. 14 ± 3 ms), longer APD90 (187 ± 6 vs. 162 ± 6 ms) and lower IK1 density compared with control rabbits. Hypertensive rabbits treated with losartan (LVH/Losartan) had HW/BW (2.36 ± 0.06 g/kg) between those of LVH/Vehicle and control rabbits, whereas MAP (65 ± 2 mm Hg), VFT (34 ± 2 mA), dispersion of ERP (19 ± 1 ms), APD90 (160 ± 6 ms), and IK1 density were significantly different from LVH/Vehicle but similar to control. We conclude that AT1 blockade in renovascular hypertensive rabbits normalizes ventricular electrophysiology.
Cyclosporin‐A inhibits stretch‐induced changes in myosin heavy chain expression in C2C12 skeletal muscle cells

Studies in vivo, have shown that passive stretch of skeletal muscle induces changes in contractile protein expression. In the present study the effects of passive stretch upon myosin heavy chain (MyHC) expression were examined in C2C12 cell myotubes. Passive stretch induced an upregulation of adult fast and slow MyHCs, which was prevented by cyclosporin A (CsA), an inhibitor of calcineurin. Calcineurin has been shown to act via the dephosphorylation of NFAT and MEF2 transcriptional factors. In this study no significant change in the phosphorylation state of these factors was observed. In contrast stretch induced an alteration in the levels of the myogenic regulatory factors (MRFs) MyoD, myogenin and myf5. The modulation in the level of these MRFs was also inhibited by CsA. These data indicate that changes in muscle phenotype in C2C12 can be modulated by passive stretch and some of these changes are calcineurin dependent. Copyright © 2004 John Wiley & Sons, Ltd.