Miracle-dz/UniFAR-FTUs huggingface dataset:
Statistics-free sports prediction

We use a simple machine learning model, logistically-weighted regularized linear least squares regression, in order to predict baseball, basketball, football, and hockey games. We do so using only the thirty-year record of which visiting teams played which home teams, on what date, and what the final score was. No real "statistics" are used. The method works best in basketball, likely because it is high-scoring and has long seasons. It works better in football and hockey than in baseball, but in baseball the predictions are closer to a theoretical optimum. The football predictions, while good, can in principle be made much better, and the hockey predictions can be made somewhat better. These findings tells us that in basketball, most statistics are subsumed by the scores of the games, whereas in football, further study of game and player statistics is necessary to predict games as well as can be done. Baseball and hockey lie somewhere in between.
A Multi-Compartment, Single and Multiple Dose Pharmacokinetic Study of the Vaginal Candidate Microbicide 1% Tenofovir Gel

Background Tenofovir (TFV) gel is being evaluated as a microbicide with pericoital and daily regimens. To inhibit viral replication locally, an adequate concentration in the genital tract is critical. Methods and Findings Forty-nine participants entered a two-phase study: single-dose (SD) and multi-dose (MD), were randomized to collection of genital tract samples (endocervical cells [ECC], cervicovaginal aspirate and vaginal biopsies) at one of seven time points [0.5, 1, 2, 4, 6, 8, or 24 hr(s)] post-dose following SD exposure of 4 mL 1% TFV gel and received a single dose. Forty-seven were randomized to once (QD) or twice daily (BID) dosing for 2 weeks and to collection of genital tract samples at 4, 8 or 24 hrs after the final dose, but two discontinued prior to gel application. Blood was collected during both phases at the seven times post-dose. TFV exposure was low in blood plasma for SD and MD; median Cmax was 4.0 and 3.4 ng/mL, respectively (C≤29 ng/mL). TFV concentrations were high in aspirates and tissue after SD and MD, ranging from 1.2×104 to 9.9×106 ng/mL and 2.1×102 to 1.4×106 ng/mL, respectively, and did not noticeably differ between proximal and distal tissue. TFV diphosphate (TFV-DP), the intracellular active metabolite, was high in ECC, ranging from 7.1×103 to 8.8×106 ng/mL. TFV-DP was detectable in approximately 40% of the tissue samples, ranging from 1.8×102 to 3.5×104 ng/mL. AUC for tissue TFV-DP was two logs higher after MD compared to SD, with no noticeable differences when comparing QD and BID. Conclusions Single-dose and multiple-dose TFV gel exposure resulted in high genital tract concentrations for at least 24 hours post-dose with minimal systemic absorption. These results support further study of TFV gel for HIV prevention. Trial registration ClinicalTrials.gov NCT00561496
RFX3 governs growth and beating efficiency of motile cilia in mouse and controls the expression of genes involved in human ciliopathies

Cilia are cellular organelles that play essential physiological and developmental functions in various organisms. They can be classified into two categories, primary cilia and motile cilia, on the basis of their axonemal architecture. Regulatory factor X (RFX) transcription factors have been shown to be involved in the assembly of primary cilia in Caenorhabditis elegans, Drosophila and mice. Here, we have taken advantage of a novel primary-cell culture system derived from mouse brain to show that RFX3 is also necessary for biogenesis of motile cilia. We found that the growth and beating efficiencies of motile cilia are impaired in multiciliated Rfx3–/– cells. RFX3 was required for optimal expression of the FOXJ1 transcription factor, a key player in the differentiation program of motile cilia. Furthermore, we demonstrate for the first time that RFX3 regulates the expression of axonemal dyneins involved in ciliary motility by binding directly to the promoters of their genes. In conclusion, RFX proteins not only regulate genes involved in ciliary assembly, but also genes that are involved in ciliary motility and that are associated with ciliopathies such as primary ciliary dyskinesia in humans.
Three Models of Information Processing: An Evaluation and Conceptual Integration

The three models of information processing advanced in this symposium have been developed by eminent scholars with divergent theoretical perspectives. Although the theorists apply their formulations to a wide range of empirical phenomena, the research they cite in their target articles is largely nonoverlapping. Perhaps this, as much as anything, testifies to the fact that the three formulations may not be incompatible and that, when considered in combination, they have far-reaching implications. It seems unlikely that any single formulation will ever provide a complete account of social information processing. The formulations presented in this issue have limited generality, as the authors themselves are the first to acknowledge. These formulations, like all theories of cognitive functioning, are metaphorical in nature and do not pretend to mirror the physiology of the human processing system. Therefore, they must be evaluated on the basis of their ability to explain known phenomena at the level of abstractness at which the models are defined and not on the basis of their validity. Each of these formulations calls attention to new and important theoretical issues and suggests new directions for empirical investigation. To this extent, they clearly accomplish their primary objective. The purpose of my commentary, therefore, is not to raise questions about the validity of these theories. However, I would like to place them within a more general conceptualization of social information processing that potentially allows their combined implications to be conceptually integrated and facilitates the identification of additional areas in which the theories might be applied. I first describe a general theoretical formulation that allows for multiple processes at several different stages of cognitive functioning en route to a judgment or decision. I then consider each of the three conceptualizations and its position within this broader framework. In doing so, I hope to identify some areas in which further research and theorizing could be fruitful. A General Conceptual Framework
Beyond Twin Peaks: Development and Polarization in the World Income Distribution

We study the evolution of the per-capita income distribution over 135 countries and 6 decades using variable dimension mixture models. We use reversible jump Markov chain Monte Carlo (MCMC) estimation to probabilistically determine (a) the number of component densities in the overall distribution, (b) the means and variances of each component, (c) the weight of each component in the mixture, and (d) the allocation of countries to individual components. We find that, as early as the 1950s and 1960s, the per-capita income distribution is most likely composed of two components and there is a significant amount of inter-group mobility. By 1980, the distribution changes into one that is most likely composed of three components, with a large gap opening between the means of the poorest and richest components and a much lower rate of inter-group mobility. In the 1990s and 2000s, the allocation of countries to component groups is relatively stable, as is the percentage gap between the means of the components. Rather than a hollowing out of the middle, our findings imply that more recent decades feature a large middle class of countries. We also find that the world income distribution fundamentally changed in the 1970s.
Indoor localization using a smart phone

This paper presents a novel indoor localization solution using a smart phone. Instead of building the inertial measurement unit (IMU), the integrated calibrated sensors inside the smart phone provide all the sensor information needed. Meanwhile, we avoid the complicated calibration process, when the calibration machines or workstations are not available. Since smart phones are meant to be held in hand, algorithms and methods based on walking speed reset can not be utilized. Therefore, correct orientation and step length information are indispensable. In this study, a modified Kalman filter based sensor data fusion was used to achieve accurate orientation data by detecting and minimizing the effect of magnetic field disturbance. Three methods are presented and compared to calculate each step length based on vertical acceleration using biomechanic model or empirical relation. The experimental results show that the proposed solution is capable of tracking the person indoors and to achieve a tracking accuracy of less than 0.3m.
Myosin light chain kinase inhibitor ML7 improves vascular endothelial dysfunction via tight junction regulation in a rabbit model of atherosclerosis

Vascular endothelial dysfunction (VED) is an important factor in the initiation and development of atherosclerosis (AS). Previous studies have demonstrated that endothelial permeability is increased in diet-induced AS. However, the precise underlying mechanisms remain poorly understood. The present study aimed to analyze whether the myosin light chain kinase (MLCK) inhibitor ML7 is able to improve VED and AS by regulating the expression of the tight junction (TJ) proteins zona occludens (ZO)-1 and occludin via mechanisms involving MLCK and MLC phosphorylation in high-fat diet-fed rabbits. New Zealand white rabbits were randomly divided into three groups: Control group, AS group and ML7 group. The rabbits were fed a standard diet (control group), a high-fat diet (AS group) or a high-fat diet supplemented with 1 mg/kg/day ML7 (ML7 group). After 12 weeks, endothelium-dependent relaxation and endothelium-independent relaxation were measured using high-frequency ultrasound. Administration of a high-fat diet significantly increased the levels of serum lipids and inflammatory markers in the rabbits in the AS group, as compared with those in the rabbits in the control group. Furthermore, a high-fat diet contributed to the formation of a typical atherosclerotic plaque, as well as an increase in endothelial permeability and VED. These symptoms of AS were significantly improved following treatment with ML7, as demonstrated in the ML7 group. Hematoxylin & eosin and immunohistochemical staining indicated that ML7 was able to decrease the expression of MLCK and MLC phosphorylation in the arterial wall of rabbits fed a high-fat diet. A similar change was observed for the TJ proteins ZO-1 and occludin. In addition, western blot analysis demonstrated that ML7 increased the expression levels of occludin in the precipitate, but reduced its expression in the supernatant of lysed aortas. These results indicated that occludin, which is a dynamic protein at the TJ, is associated with remodeling from cell membrane to cytoplasm. The present study was the first, to the best of our knowledge, to indicate that ML7 may ameliorate VED and AS by regulating the TJ proteins ZO-1 and occludin via mechanisms involving MLCK and MLC phosphorylation.
Improved Phylogenetic Analyses Corroborate a Plausible Position of Martialis heureka in the Ant Tree of Life

Martialinae are pale, eyeless and probably hypogaeic predatory ants. Morphological character sets suggest a close relationship to the ant subfamily Leptanillinae. Recent analyses based on molecular sequence data suggest that Martialinae are the sister group to all extant ants. However, by comparing molecular studies and different reconstruction methods, the position of Martialinae remains ambiguous. While this sister group relationship was well supported by Bayesian partitioned analyses, Maximum Likelihood approaches could not unequivocally resolve the position of Martialinae. By re-analysing a previous published molecular data set, we show that the Maximum Likelihood approach is highly appropriate to resolve deep ant relationships, especially between Leptanillinae, Martialinae and the remaining ant subfamilies. Based on improved alignments, alignment masking, and tree reconstructions with a sufficient number of bootstrap replicates, our results strongly reject a placement of Martialinae at the first split within the ant tree of life. Instead, we suggest that Leptanillinae are a sister group to all other extant ant subfamilies, whereas Martialinae branch off as a second lineage. This assumption is backed by approximately unbiased (AU) tests, additional Bayesian analyses and split networks. Our results demonstrate clear effects of improved alignment approaches, alignment masking and data partitioning. We hope that our study illustrates the importance of thorough, comprehensible phylogenetic analyses using the example of ant relationships.
Dynamometry of intrinsic hand muscles in patients with Charcot–Marie–Tooth disease

Background: Several problems are associated with manual muscle testing and dynamometry in the hands of patients with Charcot–Marie–Tooth (CMT) disease. Objective: To evaluate the efficacy of the Rotterdam Intrinsic Hand Myometer (RIHM) to directly measure intrinsic hand muscle strength in CMT disease. Methods: We measured hand muscle strength and hand function in 41 patients with CMT disease. Results: RIHM measurement of intrinsic strength had excellent reliability. We found overlapping RIHM strength values in Medical Research Council grades 3 to 5. High grip and pinch strength could be found in patients with severe intrinsic muscle weakness. RIHM measurements were more strongly correlated with fine motor skills of the hand than grip and pinch strength. Conclusions: The Rotterdam Intrinsic Hand Myometer is a reliable instrument to measure intrinsic hand muscles strength in patients with Charcot–Marie–Tooth disease, providing more detailed information than manual muscle testing and a more direct assessment of intrinsic muscle loss than grip and pinch dynamometers.
Interface design and evaluation of a personal information space for mobile learners

In response to the market penetration of mobile phones, educational institutions will soon focus on delivering information to mobile phones. This paper presents the design and evaluation of a prototype mobile application for lifelong learning. The application is a personal information space for mobile learners to access, compose and manage their learning in a variety of settings. As a result of the evaluation, a revised set of design guidelines is produced that can potentially feed into other attempts to develop a framework for designing applications for mobile learners.
Invasive pulmonary aspergillosis accompanied by soft tissue lesions during treatment of a patient with hyperthyroidism: a case report

Invasive pulmonary aspergillosis (IPA) is difficult to diagnose because it requires histopathology and tissue culture, as well as due to its rapid progression. Invasive pulmonary aspergillosis is the primary cause of pulmonary mycosis in China, which can occur in patients with neutrophil deficiency, leukaemia or lymphoma, malignant tumours, or chronic obstructive pulmonary disease with long-term corticosteroid use or bacterial exacerbations. Such fungal infections can lead to disseminated disease and death within weeks, and the mortality rate for untreated invasive aspergillosis is high. Therefore, increased awareness of invasive aspergillosis in non-traditional hosts is warranted due to the high mortality rate experienced by patients with this disease. Invasive pulmonary aspergillosis has become a principal cause of life-threatening infections in immunocompromised patients. Invasive aspergillosis frequently involves the lung parenchyma and is infrequently accompanied by soft tissue lesions. We present an unusual case of a patient with agranulocytosis that was caused by methimazole that was given to control his hyperthyroidism, and IPA that was accompanied by unusual maxillofacial soft tissue swelling that required treatment with voriconazole. Upon follow-up 11 months later, a chest computed tomography scan (CT) revealed that most lesions had been completely absorbed. Moreover, his maxillofacial ulcers had become encrusted, and the soft tissue swelling had subsided.
Global Correspondence Optimization for Non‐Rigid Registration of Depth Scans

We present a registration algorithm for pairs of deforming and partial range scans that addresses the challenges of non‐rigid registration within a single non‐linear optimization. Our algorithm simultaneously solves for correspondences between points on source and target scans, confidence weights that measure the reliability of each correspondence and identify non‐overlapping areas, and a warping field that brings the source scan into alignment with the target geometry. The optimization maximizes the region of overlap and the spatial coherence of the deformation while minimizing registration error. All optimization parameters are chosen automatically; hand‐tuning is not necessary. Our method is not restricted to part‐in‐whole matching, but addresses the general problem of partial matching, and requires no explicit prior correspondences or feature points. We evaluate the performance and robustness of our method using scan data acquired by a structured light scanner and compare our method with existing non‐rigid registration algorithms.
Cytoskeletal Mechanics: Models of cytoskeletal mechanics based on tensegrity

Cell shape is an important determinant of cell function and it provides a regulatory mechanism to the cell. The idea that cell contractile stress may determine cell shape stability came with the model that depicts the cell as tensed membrane that surrounds viscous cytoplasm. Ingber has further advanced this idea of the stabilizing role of the contractile stress. However, he has argued that tensed intracellular cytoskeletal lattice, rather than the cortical membrane, confirms shape stability to adherent cells. Ingber introduced a special class of tensed reticulated structures, known as tensegrity architecture, as a model of the cytoskeleton. Tensegrity architecture belongs to a class of stress-supported structures, all of which require preexisting tensile stress (“prestress”) in their cable-like structural members, even before application of external loading, in order to maintain their structural integrity. Ordinary elastic materials such as rubber, polymers, or metals, by contrast, require no such prestress. A hallmark property that stems from this feature is that structural rigidity (stiffness) of the matrix is nearly proportional to the level of the prestress that it supports. As distinct from other stress-supported structures falling within the class, in tensegrity architecture the prestress in the cable network is balanced by compression of internal elements that are called struts. According to Ingber’s cellular tensegrity model, cytoskeletal prestress in generated by the cell contractile machinery and by mechanical distension of the cell. This prestress is carried mainly by the cytoskeletal actin network, and is balanced partly by compression of microtubules and partly by traction at the extracellular adhesions. The idea that the cytoskeleton maintains its structural stability through the agency of contractile stress rests on the premise that the cytoskeleton is a static network. In reality, the cytoskeleton is a dynamic network, which is exposed to dynamic loads and in which the dynamics of various biopolymers contribute to its rheological properties. Thus, the static model of the cytoskeleton provides only a limited insight into its mechanical properties (for example, near-steady-state conditions). However, our recent measurements have shown that cell rheological (dynamic) behavior may also be affected by the contractile prestress, suggesting thereby that the tensegrity idea may also account for some features of cell rheology. This chapter describes the basic idea of the cellular tensegrity hypothesis, how it applies to problems in cellular mechanics, and what its limitations are.
CD 4 + CD 25 + T-cell populations expressing CD 134 and GITR are associated with disease activity in patients with Wegener ’ s granulomatosis

Background. An increased CD4+ CD25+ T-cell population is observed in Wegener’s granulomatosis (WG). This T-cell population is not well characterized yet and their contribution to the disease pathogenesis remains obscure. Methods. Thirty patients with WG and 18 healthy controls (HC) were included in this study. The disease activity and extension were measured by the Birmingham Vasculitis Activity Score (BVAS) and the Disease Extent Index (DEI). Lymphocytes from peripheral blood were analysed by FACS for the expression of CD4, CD25, CD134 and GITR. Cytokine expression in these subsets was assessed too. Nasal, lung and renal tissues from WG patients were immunohistochemically stained for CD3 and CD134. Results. The percentage of CD134+ as well as GITR+ expressing CD4+CD25+ lymphocytes was increased in patients as compared to HC (37 ± 12% versus 27 ± 8%, P = 0.005; 18 ± 9% versus 11 ± 6%, P = 0.003). The expression of CD134 and GITR showed a significant correlation with disease activity (r = 0.5, P = 0.009; r = 0.55, P = 0.001). Most of these displayed the phenotype of effector memory T-cells (94 ± 4% and 91 ± 6%). CD134 T-cells were found in tissues affected by WG. Conclusions. CD4+CD25+ effector memory T-cells expressing CD134 and GITR seem to play a role in disease mechanisms, as suggested by their close association with disease activity and their participation in inflammatory process.
Low-Level Laser Application in the Early Myocardial Infarction Stage Has No Beneficial Role in Heart Failure

Low-level laser therapy (LLLT) has been targeted as a promising approach that can mitigate post-infarction cardiac remodeling. There is some interesting evidence showing that the beneficial role of the LLLT could persist long-term even after the end of the application, but it remains to be systematically evaluated. Therefore, the present study aimed to test the hypothesis that LLLT beneficial effects in the early post-infarction cardiac remodeling could remain in overt heart failure even with the disruption of irradiations. Female Wistar rats were subjected to the coronary occlusion to induce myocardial infarction or Sham operation. A single LLLT application was carried out after 60 s and 3 days post-coronary occlusion, respectively. Echocardiography was performed 3 days and at the end of the experiment (5 weeks) to evaluate cardiac function. After the last echocardiographic examination, LV hemodynamic evaluation was performed at baseline and on sudden afterload increases. Compared with the Sham group, infarcted rats showed increased systolic and diastolic internal diameter as well as a depressed shortening fraction of LV. The only benefit of the LLLT was a higher shortening fraction after 3 days of infarction. However, treated-LLLT rats show a lower shortening fraction in the 5th week of study when compared with Sham and non-irradiated rats. A worsening of cardiac function was confirmed in the hemodynamic analysis as evidenced by the higher LV end-diastolic pressure and lower +dP/dt and −dP/dt with five weeks of study. Cardiac functional reserve was also impaired by infarction as evidenced by an attenuated response of stroke work index and cardiac output to a sudden afterload stress, without LLLT repercussions. No significant differences were found in the myocardial expression of Akt1/VEGF pathway. Collectively, these findings illustrate that LLLT improves LV systolic function in the early post-infarction cardiac remodeling. However, this beneficial effect may be dependent on the maintenance of phototherapy. Long-term studies with LLLT application are needed to establish whether these effects ultimately translate into improved cardiac remodeling.