Miracle-dz/UniFAR-FTUs huggingface dataset:
Maillard Reaction Products in Processed Food: Pros and Cons

The Maillard reaction was first reported in 1912 by Louis-Camille Maillard, who described that upon gently heating sugars and amino acids in water, a yellow-brown color developed. The reaction that leads to these colorful compounds, firstly described from a simple observation, is actually the result of a complicated pathway of chemical reactions. The Maillard reaction is often described in food systems but it also occurs in living organisms, and in this case, it is called glycation. In biological systems, the ramifications of the Maillard reaction have been observed and analyzed, as this reaction has become important in the field of food science and medicine (Finot, 2005; Gerrard, 2002a). The consumption of Maillard Reaction Products (MRPs) has increased in recent decades and there are evidences that these substances are absorbed and may participate in pathological processes such as, cataract, diabetes, degenerative diseases, atherosclerosis and chronic renal failure. On the other hand, these compounds are responsible for essential sensory attributes of thermally processed food products, contributing to their appearance, flavor, aroma and texture. This chapter will cover the chemistry of Maillard reaction products generation, the role of these products in food acceptability, the analysis of these compounds both in food products and in the human body and the biological activities attributed to these compounds, since this is a contemporary and controversy subject in food science and nutrition field.
21st Century Parent–Child Sex Communication in the United States: A Process Review

Parent–child sex communication results in the transmission of family expectations, societal values, and role modeling of sexual health risk-reduction strategies. Parent–child sex communication’s potential to curb negative sexual health outcomes has sustained a multidisciplinary effort to better understand the process and its impact on the development of healthy sexual attitudes and behaviors among adolescents. This review advances what is known about the process of sex communication in the United States by reviewing studies published from 2003 to 2015. We used the Cumulative Index to Nursing and Allied Health Literature (CINAHL), PsycINFO, SocINDEX, and PubMed, and the key terms “parent child” AND “sex education” for the initial query; we included 116 original articles for analysis. Our review underscores long-established factors that prevent parents from effectively broaching and sustaining talks about sex with their children and has also identified emerging concerns unique to today’s parenting landscape. Parental factors salient to sex communication are established long before individuals become parents and are acted upon by influences beyond the home. Child-focused communication factors likewise describe a maturing audience that is far from captive. The identification of both enduring and emerging factors that affect how sex communication occurs will inform subsequent work that will result in more positive sexual health outcomes for adolescents.
The Advanced Anaerobic Expanded Granular Sludge Bed (AnaEG) Possessed Temporally and Spatially Stable Treatment Performance and Microbial Community in Treating Starch Processing Wastewater

This study implements temporal and spatial appraisals on the operational performance and corresponding microbial community structure of a full-scale advanced anaerobic expanded granular sludge bed (AnaEG) which was used to treat low organic loading starch processing wastewater. Results showed stable treatment efficiency could be maintained with long-term erratic influent quality, and a major reaction zone located at the bottom of the AnaEG, where the main pollutant removal rate was greater than 90%. Remarkably, high-throughput sequencing of 16S rRNA gene amplicons displayed that the predominant members constructed the major part of the overall microbial community and showed highly temporal stability. They were affiliated to Chloroflexi (16.4%), Proteobacteria (14.01%), Firmicutes (8.76%), Bacteroidetes (7.85%), Cloacimonetes (3.21%), Ignavibacteriae (1.80%), Synergistetes (1.11%), Thermotogae (0.98%), and Euryarchaeota (3.18%). This part of microorganism implemented the long-term stable treatment efficiency of the reactor. Simultaneously, an extraordinary spatial homogeneity in the granule physic properties and microbial community structure along the vertical direction was observed within the AnaEG. In conclusion, the microbial community structure and the bioreactor’s performance showed notable spatial and temporal consistency, and the predominant populations guaranteed a long-term favorable treatment performance of the AnaEG. It provides us with a better understanding of the mechanism of this recently proposed anaerobic reactor which was used in low organic loading wastewater treatment.
Ethics support in community care makes a difference for practice

Background: Through the Norwegian ethics project, ethics activities have been implemented in the health and care sector in more than 200 municipalities. Objectives: To study outcomes of the ethics activities and examine which factors promote and inhibit significance and sustainability of the activities. Research design: Two online questionnaires about the municipal ethics activities. Participants and research context: A total of 137 municipal contact persons for the ethics project answered the first survey (55% response rate), whereas 217 ethics facilitators responded to the second survey (33% response rate). Ethical considerations: Based on informed consent, the study was approved by the Data Protection Official of the Norwegian Social Science Data Services. Findings: Around half of the respondents found the ethics project to have been highly significant for daily professional practice. Outcomes include better handling of ethical challenges, better employee cooperation, better service quality, and better relations to patients and next of kin. Factors associated with sustainability and/or significance of the activities were sufficient support from stakeholders, sufficient available time, and ethics facilitators having sufficient knowledge and skills in ethics and access to supervision. Discussion: This study shows that ethics initiatives can be both sustainable and significant for practice. There is a need to create regional or national structures for follow-up and develop more comprehensive ethics training for ethics facilitators. Conclusion: It is both possible and potentially important to implement clinical ethics support activities in community health and care services systematically on a large scale. Future ethics initiatives in the community sector should be designed in light of documented promoting and inhibiting factors.
Diagnosis and Interim Treatment Outcomes from the First Cohort of Multidrug-Resistant Tuberculosis Patients in Tanzania

Setting Kibong’oto National Tuberculosis Hospital (KNTH), Kilimanjaro, Tanzania. Objective Characterize the diagnostic process and interim treatment outcomes from patients treated for multidrug-resistant tuberculosis (MDR-TB) in Tanzania. Design A retrospective cohort study was performed among all patients treated at KNTH for pulmonary MDR-TB between November 2009 and September 2011. Results Sixty-one culture-positive MDR-TB patients initiated therapy, 60 (98%) with a prior history of TB treatment. Forty-one (67%) were male and 9 (14%) were HIV infected with a mean CD4 count of 424 (±106) cells/µl. The median time from specimen collection to MDR-TB diagnosis and from diagnosis to initiation of MDR-TB treatment was 138 days (IQR 101–159) and 131 days (IQR 32–233), respectively. Following treatment initiation four (7%) patients died (all HIV negative), 3 (5%) defaulted, and the remaining 54 (89%) completed the intensive phase. Most adverse drug reactions were mild to moderate and did not require discontinuation of treatment. Median time to culture conversion was 2 months (IQR 1–3) and did not vary by HIV status. In 28 isolates available for additional second-line drug susceptibility testing, fluoroquinolone, aminoglycoside and para-aminosalicylic acid resistance was rare yet ethionamide resistance was present in 9 (32%). Conclusion The majority of MDR-TB patients from this cohort had survived a prolonged referral process, had multiple episodes of prior TB treatment, but did not have advanced AIDS and converted to culture negative early while completing an intensive inpatient regimen without serious adverse event. Further study is required to determine the clinical impact of second-line drug susceptibility testing and the feasibility of alternatives to prolonged hospitalization.
A Comparative Analysis of Music Similarity Measures in Music Information Retrieval Systems

The digitization of music has seen a considerable increase in audience size from a few localized listeners to a wider range of global listeners. At the same time, the digitization brings the challenge of smoothly retrieving music from large databases. To deal with this challenge, many systems which support the smooth retrieval of musical data have been developed. At the computational level, a query music piece is compared with the rest of the music pieces in the database. These systems, music information retrieval (MIR systems), work for various applications such as general music retrieval, plagiarism detection, music recommendation, and musicology. This paper mainly addresses two parts of the MIR research area. First, it presents a general overview of MIR, which will examine the history of MIR, the functionality of MIR, application areas of MIR, and the components of MIR. Second, we will investigate music similarity measurement methods, where we provide a comparative analysis of state of the art methods. The scope of this paper focuses on comparative analysis of the accuracy and efficiency of a few key MIR systems. These analyses help in understanding the current and future challenges associated with the field of MIR systems and music similarity measures.
Photoacoustic technique to measure temperature effects on microbubble viscoelastic properties.

Phospholipid-coated microbubbles are being developed for several biomedical applications, but little is known about the effect of temperature on the viscoelastic properties of the shell. Here, we report on the use of a photoacoustic technique to study the shell properties of individual microbubbles as a function of temperature. The microbubbles were driven into small-amplitude oscillations by ultrasound waves generated from the absorption of an intensity-modulated infrared laser, and these oscillations were detected by forward-light scattering of a second blue laser. The drive laser modulation frequency was swept to determine the resonant response of 2-4 μm radius microbubbles. Lipid shell elasticity and viscosity were determined by modeling the microbubble response as a linear harmonic oscillator. The results from slow heating showed a linear decrease in elasticity and viscosity between 21 and 53 °C and a corresponding increase in the maximum oscillation amplitude. Rapid heating to 38 °C, on the other hand, showed a transient response in the viscoelastic properties, suggesting shell rupture and reformation during microbubble growth and subsequent dissolution. These effects are important for biomedical applications, which require warming of the microbubbles to body temperature.
Commentary: Global, regional, and national burden of neurological disorders during 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015

Citation: Karikari TK, Charway-Felli A, Höglund K, Blennow K and Zetterberg H (2018) Commentary: Global, regional, and national burden of neurological disorders during 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015. Front. Neurol. 9:201. doi: 10.3389/fneur.2018. 00201 Commentary: Global, regional, and national burden of neurological disorders during 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015
Decreased interferon‐β induced STAT‐4 activation in immune cells and clinical outcome in multiple sclerosis

Interferon‐β (IFN‐β) is used in the treatment of multiple sclerosis (MS). IFN‐β activation of signal transduction and activation of transcription (STAT)‐4 is linked to its immunomodulatory effects. Previous studies suggest a type I IFN deficit in immune cells of patients MS, but data on interferon‐α/β receptor (IFNAR) expression and the relationship with treatment response are conflicting. Here, we compare IFN‐β‐mediated STAT4 activation in immune cells of untreated patients with MS and controls.
Harmonic analysis of peripheral pulse for screening subjects at high risk of diabetes

Abstract Power spectral density (PSD) of peripheral pulses in human has been investigated in the past for its clinical applications. Continuing the efforts, data acquired using Peripheral Pulse Analyser in research projects sponsored by Board of Research in Nuclear Sciences in 207 control subjects, 18 descendants of diabetic patients and 22 patients with systemic hypertension have been subjected to PSD analysis for its study of harmonics. Application software, named Pulse Harmonic Analyser specifically developed for this work, selected 131,072 samples from each data file, obtained PSD, derived 52 PHA parameters and saved them in an Excel sheet. Coefficient of variation in control data was reduced significantly by application of Central Limit Theorem, which enabled use of parametric methods for statistical analysis of the observations. Data in hypertensive patients have shown significant difference in comparison to that of controls in eight parameters at low values of α and β. Data in offspring of diabetic patients also have shown significant difference in one parameter indicating its usefulness in screening subjects with genetic disposition of acquiring Type-II Diabetes. PHA analysis has also yielded sub-harmonic components, which are related to combined variability in the heart rate, pulse volume and pulse morphology and has a potential to become method of choice for real time variability monitoring.
Precision Light for the Treatment of Psychiatric Disorders

Circadian timekeeping can be reset by brief flashes of light using stimulation protocols thousands of times shorter than those previously assumed to be necessary for traditional phototherapy. These observations point to a future where flexible architectures of nanosecond-, microsecond-, and millisecond-scale light pulses are compiled to reprogram the brain's internal clock when it has been altered by psychiatric illness or advanced age. In the current review, we present a chronology of seminal experiments that established the synchronizing influence of light on the human circadian system and the efficacy of prolonged bright-light exposure for reducing symptoms associated with seasonal affective disorder. We conclude with a discussion of the different ways that precision flashes could be parlayed during sleep to effect neuroadaptive changes in brain function. This article is a contribution to a special issue on Circadian Rhythms in Regulation of Brain Processes and Role in Psychiatric Disorders curated by editors Shimon Amir, Karen Gamble, Oliver Stork, and Harry Pantazopoulos.
Increased lung preproET-1 and decreased ETB-receptor gene expression in fetal pulmonary hypertension.

Endothelin (ET)-1, a potent vasoconstrictor and smooth muscle mitogen, is produced from its precursor, preproET-1, by endothelin-converting enzyme (ECE)-1 activity. ET-1 may bind to two receptors, ETA and ETB, that mediate vasoconstriction and vasodilation in the ovine fetal lung, respectively. ET-1 contributes to high pulmonary vascular resistance in experimental perinatal pulmonary hypertension induced by ligation of the ductus arteriosus in the fetal lamb. Physiological studies in this model have demonstrated enhanced ETA- and diminished ETB-receptor activities and a threefold increase in lung immunoreactive ET-1 protein content. We hypothesized that increased ET production and an imbalance in receptor expression would favor vasoconstriction and smooth muscle cell hypertrophy in pulmonary hypertension and may be partially due to alterations in gene expression. To test this hypothesis, we studied lung mRNA expression of preproET-1, ECE-1, and the ETA and ETB receptors in normal and hypertensive fetal lambs. Total RNA was isolated from whole lung tissue in normal late-gestation fetuses (135 ± 3 days; 147 days = term) and from animals with pulmonary hypertension after ductus arteriosus ligation for 8 days (134 ± 4 days). Ductus arteriosus ligation increased right ventricular hypertrophy [control 0.56 ± 0.02 vs. hypertension 0.85 ± 0.05; right ventricle/(left ventricle + septum); P < 0.05]. Northern blot analysis was performed using cDNA probes and was normalized to the signal for 18S rRNA. We found a 71 ± 24% increase in steady-state preproET-1 mRNA ( P < 0.05) and a 62 ± 5% decrease in ETB mRNA ( P < 0.05) expression in ductus arteriosus ligation. ECE-1 and ETA-receptor mRNA expression did not change. We conclude that chronic intrauterine pulmonary hypertension after ductus arteriosus ligation increases steady-state preproET-1 mRNA and decreases ETB-receptor mRNA without changing ECE-1 mRNA or ETA-receptor mRNA expression. These findings suggest that increased ET-1 production and decreased ETB-receptor expression may contribute to increased vasoconstrictor tone in this experimental model of neonatal pulmonary hypertension.
Characterization of a novel endo-type alginate lyase derived from Shewanella sp. YH1

Alginate, which is an anionic polysaccharide, is widely distributed in the cell wall of brown algae. Alginate and the products of its degradation (oligosaccharides) are used in stabilizers, thickeners and gelling agents, especially in the food industry. The degradation of alginate generally involves a combination of several alginate lyases (exo-type, endo-type and oligoalginate lyase). Enhancing the efficiency of the production of alginate degradation products may require the identification of novel alginate lyases with unique characteristics. In this study, we isolated an alginate-utilizing bacterium, Shewanella sp. YH1, from seawater collected off the coast of Tottori prefecture, Japan. The detected novel alginate lyase was named AlgSI-PL7, and was classified in polysaccharide lyase family 7. The enzyme was purified from Shewanella sp. YH1 and a recombinant AlgSI-PL7 was produced in Escherichia coli. The optimal temperature and pH for enzyme activity were around 45°C and 8, respectively. Interestingly, we observed that AlgSI-PL7 was not thermotolerant, but could refold to its active form following an almost complete denaturation at approximately 60°C. Moreover, the degradation of alginate by AlgSI-PL7 produced two to five oligosaccharides, implying this enzyme was an endo-type lyase. Our findings suggest that AlgSI-PL7 may be useful as an industrial enzyme.
Integrated strategy of differentially expressed genes associated with ulcerative colitis

Ulcerative colitis (UC) is a chronic inflammatory bowel disease that is associated with both genetic and environmental factors; however, the underlying pathogenesis of UC remains unclear. The present study aimed to further explore 12 microarray datasets from patients with UC obtained from the Gene Expression Omnibus repository, for potential genetic pathogenesis of UC through a global bioinformatics view, which included identification of differentially expressed genes (DEGs), functional enrichments, protein-protein interactions, transcriptional and post-transcriptional regulation and drug-gene associations. This integrated analysis screened 233 DEGs that were compared between UC and normal control tissue samples; these included 173 upregulated and 60 downregulated DEGs. Subsequently, transcription factors, such as TATA-binding protein 1 (TBP1; hsa_TATAAA_V$TATA_01) and nuclear factor-κB (NF-κB; hsa_V$NFKAPPAB_01) and microRNAs (miRNAs; such as miR-516-3p and miR-23a) were revealed to be associated with 233 DEGs. Notably, further analysis indicated that these DEGs were enriched in certain diseases, including inflammation, fibrosis and immune system diseases, and were also associated with some drugs, including prednisone, collagenase and mycophenolate mofetil, which may provide choice for treatment of UC. In conclusion, this study may provide novel insights into discovering potential molecular targets involved in the pathogenesis and treatment of UC.
On-chip face recognition system design with memristive Hierarchical Temporal Memory

Hierarchical Temporal Memory is a new machine learning algorithm intended to mimic the working principle of neocortex, part of the human brain, which is responsible for learning, classification, and making predictions. Although many works illustrate its effectiveness as a software algorithm, hardware design for HTM remains an open research problem. Hence, this work proposes an architecture for HTM Spatial Pooler and Temporal Memory with learning mechanism, which creates a single image for each class based on important and unimportant features of all images in the training set. In turn, the reduction in the number of templates within database reduces the memory requirements and increases the processing speed. Moreover, face recognition analysis indicates that for a large number of training images, the proposed design provides higher accuracy results (83.5\%) compared to only Spatial Pooler design presented in the previous works.
Differential modulation of innate immune response by epinephrine and estradiol

Abstract Background Although it is widely accepted that catecholamines and estrogens influence immunity and have consequences for health, their effect on innate immunity (e.g. monocytes and neutrophils) is still not fully investigated. Materials and methods Our study aimed to analyze the production of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, monocyte chemoattractant protein (MCP)-1 and IL-8 by whole blood cells following short-term exposure to epinephrine (Epi) and 17β-estradiol (E2) in the presence or absence of lipopolysaccharide (LPS). We also evaluated the in vitro effect of these hormones on expression of β2 integrin (CD11b/CD18) and L-selectin (CD62L) by circulating neutrophils and monocytes in the blood of healthy subjects. Results Epi has shown a potential to modulate the production of pro-inflammatory mediators. Its exposure resulted in significantly increased production of IL-8 in a dose-dependent manner. On the contrary, a dose-dependent suppression of LPS-induced production of IL-1β, IL-8, and MCP-1 by Epi was observed. In neutrophils, a modest rise in CD11b expression was observed after Epi exposure. Simultaneously, Epi suppressed LPS-induced expression of CD11b and CD18. In monocytes, Epi suppressed LPS-induced expression of C11b. E2 inhibited LPS-induced TNF-α production and caused a significant decrease in CD62L expression in both cell populations. No significant changes were observed after double exposure of cells with Epi and E2. Conclusions Thus, our results show that Epi and E2 differentially modulate the innate immune response and have a dual effect on cytokine modulation. The findings suggest that the observed immunoregulatory role of Epi and E2 may influence the outcome in endotoxin responses and can be critical in the regulation of inflammatory responses.