Miracle-dz/UniFAR-FTUs huggingface dataset:
Aluminium-induced ion transport in Arabidopsis: the relationship between Al tolerance and root ion flux

Aluminium (Al) rhizotoxicity coincides with low pH; however, it is unclear whether plant tolerance to these two factors is controlled by the same mechanism. To address this question, the Al-resistant alr104 mutant, two Al-sensitive mutants (als3 and als5), and wild-type Arabidopsis thaliana were compared in long-term exposure (solution culture) and in short-term exposure experiments (H+ and K+ fluxes, rhizosphere pH, and plasma membrane potential, Em). Based on biomass accumulation, als5 and alr104 showed tolerance to low pH, whereas alr104 was tolerant to the combined low-pH/Al treatment. The sensitivity of the als5 and als3 mutants to the Al stress was similar. The Al-induced decrease in H+ influx at the distal elongation zone (DEZ) and Al-induced H+ efflux at the mature zone (MZ) were higher in the Al-sensitive mutants (als3 and als5) than in the wild type and the alr104 mutant. Under combined low-pH/Al treatment, alr104 and the wild type had depolarized plasma membranes for the entire 30 min measurement period, whereas in the Al-sensitive mutants (als3 and als5), initial depolarization to around –60 mV became hyperpolarization at –110 mV after 20 min. At the DEZ, the Em changes corresponded to the changes in K+ flux: K+ efflux was higher in alr104 and the wild type than in the als3 and als5 mutants. In conclusion, Al tolerance in the alr104 mutant correlated with Em depolarization, higher K+ efflux, and higher H+ influx, which led to a more alkaline rhizosphere under the combined low-pH/Al stress. Low-pH tolerance (als5) was linked to higher H+ uptake under low-pH stress, which was abolished by Al exposure.
Flexible working times : effects on employees' exhaustion, work-nonwork conflict and job performance

Purpose – The aim of this study is to provide a useful conceptualization of flexible working times and to examine the relationships between flexible working times and employees' well‐being and peer ratings of performance. It is supposed that an employee's “time‐autonomy” would be positively related to performance and well‐being. On the contrary, an unfavorable effect of “time restriction” on well‐being is expected.Design/methodology/approach – A questionnaire‐study was conducted among 167 German employees from 17 different organizations. Information about in‐role and extra‐role performance was also obtained via peer evaluations.Findings – The data support a two‐factor structure of flexibility. The time restriction factor adds to the degree of exhaustion and the work‐nonwork conflict, while time autonomy diminishes these outcome variables. However, the flexibility dimensions are unrelated to performance.Originality/value – The multidimensional conceptualization of flexibility allows for the detection of ad.
‘Waving the banana’ at capitalism: Political theater and social movement strategy among New York’s ‘freegan’ dumpster divers

This article presents an ethnographic study of ‘freegans’, individuals who use behaviors like dumpster diving for discarded food and voluntary unemployment to protest against environmental degradation and capitalism. While freegans often present their ideology as a totalizing lifestyle which impacts all aspects of their lives, in practice, freegans emphasize what would seem to be the most repellant aspect of their movement: eating wasted food. New Social Movement (NSM) theory would suggest that behaviors like dumpster diving are intended to assert difference and an alternative identity, rather than make more traditional social movement claims. Through the lens of social dramaturgy, I engage with New Social Movement theory by arguing that unconventional tactics like dumpster diving can also have strategic components, serving to project a favorable image of movement organizations, recruit new participants, and achieve a positive portrayal in the mainstream media.
Scalable Collaborative Filtering Approaches for Large Recommender Systems

The collaborative filtering (CF) using known user ratings of items has proved to be effective for predicting user preferences in item selection. This thriving subfield of machine learning became popular in the late 1990s with the spread of online services that use recommender systems, such as Amazon, Yahoo! Music, and Netflix. CF approaches are usually designed to work on very large data sets. Therefore the scalability of the methods is crucial. In this work, we propose various scalable solutions that are validated against the Netflix Prize data set, currently the largest publicly available collection. First, we propose various matrix factorization (MF) based techniques. Second, a neighbor correction method for MF is outlined, which alloys the global perspective of MF and the localized property of neighbor based approaches efficiently. In the experimentation section, we first report on some implementation issues, and we suggest on how parameter optimization can be performed efficiently for MFs. We then show that the proposed scalable approaches compare favorably with existing ones in terms of prediction accuracy and/or required training time. Finally, we report on some experiments performed on MovieLens and Jester data sets.
An EMG-based approach for on-line predicted torque control in robotic-assisted rehabilitation

This paper proposes a sEMG-based method for on-line torque prediction and control of robot joints. More in detail, the Mean Absolute Value (MAV) features extracted from the sEMG signals acquired from five muscles of the shoulder and of the elbow are used as input to two trained time delayed neural networks (TDNNs) to estimate the joint torque of an active exoskeleton robot for movements executed in the sagittal plane. The sEMG-driven TDNNs, trained with a dataset composed by shoulder and elbow joint torque values registered in isometric conditions, allow to on-line control the exoskeleton joints for slow movements of the upper limbs. Finally, the method was tested and validated through experiments conducted on a healthy subject.
Mechanism of Irk1 Channel Block by Intracellular Polyamines

Intracellular polyamines inhibit the strongly rectifying IRK1 potassium channel by a mechanism different from that of a typical ionic pore blocker such as tetraethylammonium. As in other K+ channels, in the presence of intracellular TEA, the IRK1 channel current decreases with increasing membrane voltage and eventually approaches zero. However, in the presence of intracellular polyamines, the channel current varies with membrane voltage in a complex manner: when membrane voltage is increased, the current decreases in two phases separated by a hump. Furthermore, contrary to the expectation for a nonpermeant ionic pore blocker, a significant residual IRK1 current persists at very positive membrane voltages; the amplitude of the residual current decreases with increasing polyamine concentration. This complex blocking behavior of polyamines can be accounted for by a minimal model whereby intracellular polyamines inhibit the IRK1 channel by inducing two blocked channel states. In each of the blocked states, a polyamine is bound with characteristic affinity and probability of traversing the pore. The proposal that polyamines traverse the pore at finite rates is supported by the observation that philanthotoxin-343 (spermine with a bulky chemical group attached to one end) acts as a nonpermeant ionic blocker in the IRK1 channel.
The Importance of Trivial Streets: Residential Streets and Residential Segregation1

Previous models of urban residential segregation have virtually ignored the affects of tertiary, or small, residential–type streets, despite the intuition that they are where “neighborly” relations primarily occur. This article argues that racial similarity among neighborhoods emerges primarily from their relational connections via tertiary streets rather than as a result of geographic proximity. Analyzing tertiary streets can better predict racial composition than can spatial considerations. Segregated networks of neighborly relations emerge from segregated networks of residential streets. Racial populations are organized in space with respect to who is “down the street” rather than in terms of mere physical distance.
Treatment of Experimental Autoimmune Encephalomyelitis with Genetically Modified Memory T Cells

The migratory properties of memory T cells provide a model vector system for site-specific delivery of therapeutic transgene factors to autoimmune inflammatory lesions. Lymph node cells from (SWR×SJL)F1 mice immunized with the p139–151 determinant of myelin proteolipid protein (PLP) were transfected with a DNA construct that placed the anti-inflammatory cytokine interleukin-10 (IL-10) cDNA under control of an antigen-inducible IL-2 promoter region. Isolated T cell clones demonstrated antigen-inducible expression of transgene IL-10 and expressed cell surface markers consistent with the phenotype of normal memory T cells. Upon adoptive transfer, transfected T cell clones were able to inhibit onset of experimental autoimmune encephalomyelitis (EAE) and to treat EAE animals therapeutically after onset of neurologic signs. Semiquantitative immunocytochemistry showed a significant correlation between decreased demyelination and treatment with the transfected T cells. Taken together, these data indicate the autoreactive T cells can be genetically designed to produce therapeutic factors in an antigen-inducible manner resulting in a decreased severity of clinical and histological autoimmune demyelinating disease.
Factors associated with refusal to treat HIV-infected patients: the results of a national survey of dentists in Canada.

OBJECTIVES This study investigated dentists refusal to treat patients who have HIV. METHODS A survey was mailed to a random sample of all licensed dentists in Canada, with 3 follow-up attempts (n = 6444). Data were weighted to allow for probability of selection and nonresponse and analyzed with Pearson's chi 2 and multiple logistic regression. RESULTS The response rate was 66%. Of the respondents, 32% had knowingly treated HIV-infected patients in the last year; 16% would refuse to treat HIV-infected patients. Respondents reported willingness to treat HIV-infected patients (81%), injection drug users (86%), hepatitis B virus-infected patients (87%), homosexual and bisexual persons (94%), individuals with sexually transmitted disease(s) (94%), and recipients of blood and blood products (97%). The best predictors of refusal to treat patients with HIV were lack of ethical responsibility (odds ratio = 9.0) and items related to fear of cross-infection or lack of knowledge of HIV. CONCLUSIONS One in 6 dentists reported refusal to treat HIV-infected patients, which was associated primarily with respondents' lack of belief in an ethical responsibility to treat patients with HIV and fears related to cross-infection. These results have implications for undergraduate, postgraduate, and continuing education.
Beliefs and fears and Type A behavior: implications for academic performance and psychiatric health disorder symptoms

Summary This study begins by examining the dimensionality of the Type A behavior pattern using four frequently employed self-report measures. Exploratory and confirmatory factor analyses identified nine meaningful factors (dimensions) across the four scales. A measure of hostility was added since hostility has been found to be highly predictive of coronary heart disease and originally was included in Rosenman, Swan and Carmelli's (1988) definition of Type A behavior. Supporting the utility of examining Type A behavior as a multidimensional personality construct, the Type A dimensions and hostility reveal differential effects on academic performance and a general health or psychiatric disorder symptom profile. Achievement striving is positively related to academic performance, and time pressure, anger, and hostility seem to significantly increase somatic complaints, anxiety, and depression. In addition, there is support for Price's (1982) conceptualization that some cognitive beliefs and fears promote the development and maintenance of Type A behavior. As expected, the belief and fear that one must prove oneself or else be judged unworthy relates positively to work involvement and achievement striving, but it also directly and positively impacts the overt Type A behaviors of hurry and time pressure and two psychiatric health disorder symptoms, performance dysfunction and anxiety. Lastly, implications and future research directions are discussed.
Robust regression and posterior predictive simulation increase power to detect early bursts of trait evolution.

A central prediction of much theory on adaptive radiations is that traits should evolve rapidly during the early stages of a clade's history and subsequently slowdown in rate as niches become saturated--a so-called "Early Burst. " Although a common pattern in the fossil record, evidence for early bursts of trait evolution in phylogenetic comparative data has been equivocal at best. We show here that this may not necessarily be due to the absence of this pattern in nature. Rather, commonly used methods to infer its presence perform poorly when when the strength of the burst--the rate at which phenotypic evolution declines--is small, and when some morphological convergence is present within the clade. We present two modifications to existing comparative methods that allow greater power to detect early bursts in simulated datasets. First, we develop posterior predictive simulation approaches and show that they outperform maximum likelihood approaches at identifying early bursts at moderate strength. Second, we use a robust regression procedure that allows for the identification and down-weighting of convergent taxa, leading to moderate increases in method performance. We demonstrate the utility and power of these approach by investigating the evolution of body size in cetaceans. Model fitting using maximum likelihood is equivocal with regards the mode of cetacean body size evolution. However, posterior predictive simulation combined with a robust node height test return low support for Brownian motion or rate shift models, but not the early burst model. While the jury is still out on whether early bursts are actually common in nature, our approach will hopefully facilitate more robust testing of this hypothesis. We advocate the adoption of similar posterior predictive approaches to improve the fit and to assess the adequacy of macroevolutionary models in general.
Drugs, crime and social exclusion: social context and social theory in British drugs-crime research

The association between drugs and crime is one of the central concerns of contemporary British drugs research and policy. Another major concern in recent years has been the clustering together of the most serious problems of drugs and crime in neighbourhoods already experiencing multiple social and economic difficulties. This paper seeks, first of all, to re-situate the drug-crime nexus in its full social context in order to provide a new perspective on these two key aspects of the British drug problem today. In doing so, the analysis raises in applied form some important issues in criminological theory and the paper attempts, secondly, to make a contribution to these theoretical debates.
Development and Preliminary Validation of a New Scale (LMX-6) to Measure Leader-Member Exchange in Organizations

Based on conceptualizing leader-member exchange quality as comprised of the three subdimensions of perceived contribution to the exchange, loyalty, and positive affect, a short (6-item) new LMX scale was developed (LMX-6). Using data from two samples (N = 281 and 115), the three-dimensional structure of the new scale was confirmed by multiple maximum likelihood confirmatory factors analyses in each sample separately. The two-and one-week test-retest stability of the new scale was established in a third (N = 86) and fourth (N = 44) sample, and acceptable internal-consistency estimates of reliability obtained for all four samples. The LMX-6 scale showed a high (.82) and statistically significant (p < .001) correlation with a commonly-used measure of leader-member exchange in the fourth sample. Finally, in the first two samples, concurrent correlations with autocratic and delegative decision-making, job satisfaction, organizational commitment, and rated job performance supported the validity of the new scale. Directions for future research are briefly discussed.
Lactoseries carbohydrates specify subsets of dorsal root ganglion neurons projecting to the superficial dorsal horn of rat spinal cord

Cell surface carbohydrates are thought to play important roles in the development and differentiation of mammalian cells. In previous studies we have found that one population of dorsal root ganglion (DRG) neurons is specified by the expression of complex globoseries oligosaccharides (Dodd, J., D. Solter, and T. M. Jessell (1984) Nature 311: 469–472; Jessell, T. M. , and J. Dodd (1985) Philos. Trans. R. Soc. Lond. (Biol.) 308: 271–281). We now report that monoclonal antibodies (MAbs) directed against backbone structures of lactoseries oligosaccharides define antigens present in the cytoplasm of a second, anatomically and functionally distinct subset of DRG neurons. Lactoseries carbohydrate structures identified by MAb A5 are restricted to small- and intermediate-diameter DRG neurons with central projections in the superficial dorsal horn of the rat spinal cord. The distribution of labeled terminals suggests that many of the DRG neurons that express lactoseries carbohydrates are likely to convey nociceptive information. More complex galactose- and fucose-substituted lactoseries structures recognized by MAbs LD2, KH10, TC6, TD10, LA4, and anti-Lewis a are segregated on subsets of DRG neurons that differ in their expression of substance P, somatostatin, and fluoride-resistant acid phosphatase and in their laminar termination in the superficial dorsal horn. The majority of lactoseries carbohydrate antigens identified in the cytoplasm of DRG neurons are also expressed on the surface of subsets of DRG neurons in culture. These studies establish that structurally defined carbohydrate differentiation antigens specify the majority of primary sensory neurons with cutaneous receptive fields. Moreover, lactoseries carbohydrate structures similar or identical to those expressed on neonatal DRG neurons in culture have been implicated in cell-cell interactions at early stages of preimplantation embryonic development. Our observations suggest strategies for testing the hypothesis that carbohydrates present on the surface of subsets of DRG neurons play a role in cell interactions that contribute to the laminar organization of sensory afferents in the developing spinal cord.
A RecG-Independent Nonconservative Branch Migration Mechanism in Escherichia coli Recombination

ABSTRACT To gain insight regarding the mechanisms that extend heteroduplex joints in Escherichia coli recombination, we investigated the effect of recG and ruv genotypes on heteroduplex strand polarity in intramolecular recombination products. We also examined the cumulative effect of mutational inactivation of RecG and single-strand-specific exonucleases on recombination proficiency and the role of Chi sites in RecG-independent recombination. All four strands of the two homologs were incorporated into heteroduplex structures in wild-type cells and in ruvmutants. However, in recG mutants heteroduplexes were generated almost exclusively by pairing the invasive 3′-ending strand with its complementary strand. To explain the dependence of strand exchange reciprocity on RecG activity, we propose that alternative mechanisms may extend the heteroduplex joints after homologous pairing: a reciprocal RecG-mediated mechanism and a nonreciprocal mechanism, mediated by RecA and single-strand-specific exonucleases. The cumulative effect of recG and recJ orxonA mutations on recombination proficiency and the inhibitory effect of recJ and xonA activities on heteroduplex formation by the 5′-ending strands are consistent with this proposal.
Adaptive mesh refinement with spectral accuracy for magnetohydrodynamics in two space dimensions

We examine the effect of accuracy of high-order spectral element methods, with or without adaptive mesh refinement (AMR), in the context of a classical configuration of magnetic reconnection in two space dimensions, the so-called Orszag–Tang (OT) vortex made up of a magnetic X-point centred on a stagnation point of the velocity. A recently developed spectral-element adaptive refinement incompressible magnetohydrodynamic (MHD) code is applied to simulate this problem. The MHD solver is explicit, and uses the Elsässer formulation on high-order elements. It automatically takes advantage of the adaptive grid mechanics that have been described elsewhere in the fluid context (Rosenberg et al 2006 J. Comput. Phys. 215 59–80); the code allows both statically refined and dynamically refined grids. Tests of the algorithm using analytic solutions are described, and comparisons of the OT solutions with pseudo-spectral computations are performed. We demonstrate for moderate Reynolds numbers that the algorithms using both static and refined grids reproduce the pseudo-spectral solutions quite well. We show that low-order truncation—even with a comparable number of global degrees of freedom—fails to correctly model some strong (sup-norm) quantities in this problem, even though it satisfies adequately the weak (integrated) balance diagnostics.
Reactions to Hypothetical, Jealousy Producing Events.

Two hundred twenty subjects completed questionnaires in which they were asked to rate how they would feel about their mates' behavior in eight hypothetical situations designed to measure jealousy. Responses indicate that jealousy is likely to be a major issue in their marriages and question some long held assumptions concerning the relationship between jealousy and both romanticism and self-concept. Sex role orientation is the variable most consistently related to jealousy with sex role traditional subjects being the most jealous. The implications of this study for both practitioners and theorists are discussed.
Profitable portfolios: capital that counts in higher education

Under-representation in UK higher education of students from less privileged social backgrounds is an enduring problem. While there are examples of productive participation, the pattern of collective trajectories of this group differs sharply from that of traditional entrants. The onus falls largely on students to adapt to established practices that remain strongly oriented towards traditional white middle-class populations. Bourdieu's theory of practice informed the analysis of data emerging from a longitudinal case study, and empirical insights are offered into how students with non-traditional academic backgrounds experienced and negotiated the demands of studying in one of the UK's research-intensive universities. A new conceptual framework identifies academic, linguistic, social and professionally-oriented capital as underpinning the logic of practice of this sub-field of higher education, and their influence on the positional tendencies and trajectories of the students operating within it are highlighted.