Miracle-dz/UniFAR-FTUs huggingface dataset:
Experimental Synthesis of a Feed Pattern with a Dense Focal Plane Array

The 8×9 element dense tapered slot array operating over 1-7 GHz range is used to synthesize a dual-band (2.215-2.375 GHz and 4.770-5.020 GHz) feed for a F/D=0.35 reflector. Only 25 elements are excited in a concentric ring manner to simulate a conventional coaxial feed. Not only experiments, including mutual coupling effects, but also array simulations using the cos2 element power pattern give a satisfactory approximation. Recommendations of how to choose the sufficient overall dimensions of the dense array feed are developed on the basis of the focal field distribution analysis. Power losses of no more than about 5% at the boundaries of the given band relatively to the central frequency serve as a criterion determining the maximal efficiency of the reflector aperture.
Pathway to Synthesis and Processing of Mycolic Acids in Mycobacterium tuberculosis

SUMMARY Mycobacterium tuberculosis is known to synthesize α-, methoxy-, and keto-mycolic acids. We propose a detailed pathway to the biosynthesis of all mycolic acids in M. tuberculosis. Fatty acid synthetase I provides C20-S-coenzyme A to the fatty acid synthetase II system (FAS-IIA). Modules of FAS-IIA and FAS-IIB introduce cis unsaturation at two locations on a growing meroacid chain to yield three different forms of cis,cis-diunsaturated fatty acids (intermediates to α-, methoxy-, and keto-meroacids). These are methylated, and the mature meroacids and carboxylated C26-S-acyl carrier protein enter into the final Claisen-type condensation with polyketide synthase-13 (Pks13) to yield mycolyl-S-Pks13. We list candidate genes in the genome encoding the proposed dehydrase and isomerase in the FAS-IIA and FAS-IIB modules. We propose that the processing of mycolic acids begins by transfer of mycolic acids from mycolyl-S-Pks13 to d-mannopyranosyl-1-phosphoheptaprenol to yield 6-O-mycolyl-β-d-mannopyranosyl-1-phosphoheptaprenol and then to trehalose 6-phosphate to yield phosphorylated trehalose monomycolate (TMM-P). Phosphatase releases the phosphate group to yield TMM, which is immediately transported outside the cell by the ABC transporter. Antigen 85 then catalyzes the transfer of a mycolyl group from TMM to the cell wall arabinogalactan and to other TMMs to produce arabinogalactan-mycolate and trehalose dimycolate, respectively. We list candidate genes in the genome that encode the proposed mycolyltransferases I and II, phosphatase, and ABC transporter. The enzymes within this total pathway are targets for new drug discovery.
Identification of the Essential Role of Viral Bcl-2 for Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication

ABSTRACT Kaposi's sarcoma-associated herpesvirus (KSHV) evades host defenses through tight suppression of autophagy by targeting each step of its signal transduction: by viral Bcl-2 (vBcl-2) in vesicle nucleation, by viral FLIP (vFLIP) in vesicle elongation, and by K7 in vesicle maturation. By exploring the roles of KSHV autophagy-modulating genes, we found, surprisingly, that vBcl-2 is essential for KSHV lytic replication, whereas vFLIP and K7 are dispensable. Knocking out vBcl-2 from the KSHV genome resulted in decreased lytic gene expression at the mRNA and protein levels, a lower viral DNA copy number, and, consequently, a dramatic reduction in the amount of progeny infectious viruses, as also described in the accompanying article (A. Gelgor, I. Kalt, S. Bergson, K. F. Brulois, J. U. Jung, and R. Sarid, J Virol 89:5298–5307, 2015). More importantly, the antiapoptotic and antiautophagic functions of vBcl-2 were not required for KSHV lytic replication. Using a comprehensive mutagenesis analysis, we identified that glutamic acid 14 (E14) of vBcl-2 is critical for KSHV lytic replication. Mutating E14 to alanine totally blocked KSHV lytic replication but showed little or no effect on the antiapoptotic and antiautophagic functions of vBcl-2. Our study indicates that vBcl-2 harbors at least three important and genetically separable functions to modulate both cellular signaling and the virus life cycle. IMPORTANCE The present study shows for the first time that vBcl-2 is essential for KSHV lytic replication. Removal of the vBcl-2 gene results in a lower level of KSHV lytic gene expression, impaired viral DNA replication, and consequently, a dramatic reduction in the level of progeny production. More importantly, the role of vBcl-2 in KSHV lytic replication is genetically separated from its antiapoptotic and antiautophagic functions, suggesting that the KSHV Bcl-2 carries a novel function in viral lytic replication.
Dual Specificity A-kinase Anchoring Proteins (AKAPs) Contain an Additional Binding Region That Enhances Targeting of Protein Kinase A Type I*

A-kinase anchoring proteins (AKAPs) target protein kinase A (PKA) to a variety of subcellular locations. Conventional AKAPs contain a 14-18-amino acid sequence that forms an amphipathic helix that binds with high affinity to the regulatory (R) subunit of PKA type II. More recently, a group of dual specificity AKAPs has been classified on the basis of their ability to bind the PKA type I and the PKA type II isozymes. In this study we show that dual specificity AKAPs contain an additional PKA binding determinant called the RI Specifier Region (RISR). A variety of protein interaction assays and immunoprecipitation and immunolocalization experiments indicates that the RISR augments RI binding in vitro and inside cells. Cellular delivery of the RISR peptide uncouples RI anchoring to Ezrin leading to release of T cell inhibition by cAMP. Likewise, expression of mutant Ezrin forms where RI binding has been abrogated by substitution of the RISR sequence prevents cAMP-mediated inhibition of T cell function. Thus, we propose that the RISR acts in synergy with the amphipathic helix in dual specificity anchoring proteins to enhance anchoring of PKA type I.
The Warrigal Dataset: Multi-Vehicle Trajectories and V2V Communications

Intelligent Transportation Systems rely on understanding, predicting and affecting the interactions between vehicles. Development of such systems must be based upon data derived from actual interactions if they are to be effective when used in real world applications. Increasingly, systems are being developed that are based on radio communication of state and intent between vehicles. Understanding of how these interactions occur is also necessary to creating robust systems. In order to test and compare new techniques, approaches and algorithms it is necessary to have a rich dataset to experiment with. This paper presents a detailed dataset useful for members of the Intelligent Transportation Systems community. It contains vehicle state information, vehicle-to-vehicle communications and road maps at high temporal resolution for large numbers of interacting vehicles over a long time period. This data set has already been used for a number of Intelligent Transportation Systems projects such as road mapping, driver intent prediction and collision avoidance among others.
The evidence of low-intensity pulsed ultrasound for in vitro, animal and human fracture healing.

BACKGROUND Physical stimulation therapies are currently available to enhance fracture healing. SOURCES OF DATA A search of PubMed, Medline, CINAHL, DH data and Embase databases was performed using the keywords 'ultrasound' and 'fracture healing'. AREAS OF AGREEMENT The evidence in vitro and animal studies suggests that low-intensity pulsed ultrasound (LIPUS) produces significant osteoinductive effects, accelerating the healing process and improving the bone-bending strength. AREAS OF CONTROVERSY The evidence in human trials is controversial in fresh, stress fractures and in limb lengthening. LIPUS is effective in delayed unions, in smokers and in diabetic population. GROWING POINTS LIPUS is an alternative, less invasive form of treatment for complicated fractures, in patients with poor bone healing and may play a role in the management of large-scale bone defects producing substantial cost savings and decreasing associated disability. AREAS TIMELY FOR DEVELOPING RESEARCH There is heterogeneity among in vitro, animal studies and their application to human studies. Further randomized controlled trials of high methodological quality are needed.
Time Series Modelling with Fuzzy Cognitive Maps - Study on an Alternative Concept's Representation Method

In the article we have discussed an approach to time series modelling based on Fuzzy Cognitive Maps (FCMs). We have introduced FCM design method that is based on replicated ordered time series data points. We named this representation method history h, where h is number of consecutive data points we gather. Custom procedure for concepts/nodes extraction follows the same convention. The objective of the study reported in this paper was to investigate how increasing h influences modelling accuracy. We have shown on a selection of 12 time series that the higher the h, the smaller the error. Increasing h improves model’s quality without increasing FCM’s size. The method is stable gains are comparable for FCMs of different sizes.
On the Tradeoff Between Privacy and Energy in Wireless Sensor Networks

Source location privacy is becoming an increasingly important property of some wireless sensor network applica- tions. The fake source technique has been proposed as an approach for handling the source location privacy problem in these situations. However, whilst the efficiency of the fake source techniques is well documented, there are several factors that limit the usefulness of current results: (i) the assumption that fake sources are known a priori, (ii) the selection of fake sources based on an prohibitively expensive pre-configuration phase and (iii) the lack of a commonly adopted attacker model. In this paper we address these limitations by investigating the efficiency of the fake source technique with respect to possible implementations, configurations and extensions that do not require a pre-configuration phase or a priori knowledge of fake sources. The results presented demonstrate that one possible implementation, in presence of a single attacker, can lead to a decrease in capture ratio of up to 60% when compared with a flooding baseline. In the presence of multiple attackers, the same implementation yields only a 30% decrease in capture ratio with respect to the same baseline. To address this problem we investigate a hybrid technique, known as phantom routing with fake sources, which achieves a corresponding 50% reduction in capture ratio.
Impact of Atrial Fibrillation on Exercise Capacity and Mortality in Heart Failure With Preserved Ejection Fraction: Insights From Cardiopulmonary Stress Testing

Background Atrial fibrillation (AF) has been objectively associated with exercise intolerance in patients with heart failure with reduced ejection fraction; however, its impact in patients with heart failure with preserved ejection fraction has not been fully scrutinized. Methods and Results We identified 1744 patients with heart failure and ejection fraction ≥50% referred for cardiopulmonary stress testing at the Cleveland Clinic (Cleveland, OH), 239 of whom had AF. We used inverse probability of treatment weighting to balance clinical characteristics between patients with and without AF. A weighted linear regression model, adjusted for unbalanced variables (age, sex, diagnosis, hypertension, and β‐blocker use), was used to compare metabolic stress parameters and 8‐year total mortality (social security index) between both groups. Weighted mean ejection fraction was 58±5.9% in the entire population. After adjusting for unbalanced weighted variables, patients with AF versus those without AF had lower mean peak oxygen consumption (18.5±6.2 versus 20.3±7.1 mL/kg per minute), oxygen pulse (12.4±4.3 versus 12.9±4.7 mL/beat), and circulatory power (2877±1402 versus 3351±1788 mm Hg·mL/kg per minute) (P<0.001 for all comparisons) but similar submaximal exercise capacity (oxygen consumption at anaerobic threshold, 12.0±5.1 versus 12.4±6.0mL/kg per minute; P =0.3). Both groups had similar peak heart rate, whereas mean peak systolic blood pressure was lower in the AF group (150±35 versus 160±51 mm Hg; P<0.001). Moreover, AF was associated with higher total mortality. Conclusions In the largest study of its kind, we demonstrate that AF is associated with peak exercise intolerance, impaired contractile reserve, and increased mortality in patients with heart failure with preserved ejection fraction. Whether AF is the primary offender in these patients or merely a bystander to worse diastolic function requires further investigation.
Low-Frequency Local Field Potentials and Spikes in Primary Visual Cortex Convey Independent Visual Information

Local field potentials (LFPs) reflect subthreshold integrative processes that complement spike train measures. However, little is yet known about the differences between how LFPs and spikes encode rich naturalistic sensory stimuli. We addressed this question by recording LFPs and spikes from the primary visual cortex of anesthetized macaques while presenting a color movie. We then determined how the power of LFPs and spikes at different frequencies represents the visual features in the movie. We found that the most informative LFP frequency ranges were 1–8 and 60–100 Hz. LFPs in the range of 12–40 Hz carried little information about the stimulus, and may primarily reflect neuromodulatory inputs. Spike power was informative only at frequencies <12 Hz. We further quantified “signal correlations” (correlations in the trial-averaged power response to different stimuli) and “noise correlations” (trial-by-trial correlations in the fluctuations around the average) of LFPs and spikes recorded from the same electrode. We found positive signal correlation between high-gamma LFPs (60–100 Hz) and spikes, as well as strong positive signal correlation within high-gamma LFPs, suggesting that high-gamma LFPs and spikes are generated within the same network. LFPs <24 Hz shared strong positive noise correlations, indicating that they are influenced by a common source, such as a diffuse neuromodulatory input. LFPs <40 Hz showed very little signal and noise correlations with LFPs >40 Hz and with spikes, suggesting that low-frequency LFPs reflect neural processes that in natural conditions are fully decoupled from those giving rise to spikes and to high-gamma LFPs.
Molecular determination of perivesical and lymph node metastasis after radical cystectomy for urothelial carcinoma of the bladder.

PURPOSE Current methods used to determine the pathological stage of the primary tumor and associated lymphatics after radical cystectomy are tedious, costly, and may lack the sensitivity afforded by molecular approaches such as reverse transcription-PCR (RT-PCR) for markers specific for urothelial tissue such as the uroplakin II (UPII) gene. Thus, we sought to evaluate an objective and sensitive molecular approach for the assessment of perivesical extension and lymph node status after radical cystectomy, based on the detection of UPII expression using RT-PCR and compare this assay to standard clinical and pathological examination. EXPERIMENTAL DESIGN From November 1999 to September 2000, 27 patients with clinical T(a)-T(3)N(0)M(0) urothelial bladder cancer underwent radical cystectomy, 19 (70%) of which also had pelvic lymphadenectomy. At the completion of cystectomy, systematic biopsies of the external surface of the bladder specimen as well as from the largest palpable lymph node found at lymphadenectomy were obtained for molecular analysis. RT-PCR analysis for UPII mRNA was carried out on these biopsy specimens, and results were compared with data obtained from conventional pathological examination. RESULTS Pathologically organ-confined tumors had a 42% (5 of 12) incidence of positive signals in the perivesical tissues and 17% (1 of 7) in the lymph nodes. Corresponding percentages for pT(3a)N(0) and pT(3b)-T(4)N(0) lesions were 67% (4 of 6)/25% (1 of 4) and 67% (4 of 6)/33% (2 of 6), respectively. Overall, pathologically node-negative cancers had a perivesical positivity rate of 54% (13 of 24) and a lymph node positivity rate of 25% (4 of 16). All patients with pathologically positive nodes had positive UPII signals in the lymph node sample. CONCLUSIONS This molecular assay aimed at assessing perivesical extension and lymph node status after radical cystectomy appears to identify patients that may harbor residual disease not appreciated by conventional histology. Larger studies with 5-7-year follow-up will be required to determine the prognostic significance of such molecular information.
Altered fractal dynamics of gait: reduced stride-interval correlations with aging and Huntington's disease.

Fluctuations in the duration of the gait cycle (the stride interval) display fractal dynamics and long-range correlations in healthy young adults. We hypothesized that these stride-interval correlations would be altered by changes in neurological function associated with aging and certain disease states. To test this hypothesis, we compared the stride-interval time series of 1) healthy elderly subjects and young controls and of 2) subjects with Huntington's disease and healthy controls. Using detrended fluctuation analysis we computed alpha, a measure of the degree to which one stride interval is correlated with previous and subsequent intervals over different time scales. The scaling exponent alpha was significantly lower in elderly subjects compared with young subjects (elderly: 0.68 +/- 0.14; young: 0.87 +/- 0.15; P < 0.003). The scaling exponent alpha was also smaller in the subjects with Huntington's disease compared with disease-free controls (Huntington's disease: 0.60 +/- 0.24; controls: 0.88 +/-0.17; P < 0.005). Moreover, alpha was linearly related to degree of functional impairment in subjects with Huntington's disease (r = 0.78, P < 0.0005). These findings demonstrate that strike-interval fluctuations are more random (i.e., less correlated) in elderly subjects and in subjects with Huntington's disease. Abnormal alterations in the fractal properties of gait dynamics are apparently associated with changes in central nervous system control.
ETAOSD: Static dictionary-based transformation method for text compression

The aim of this paper is to present a new static dictionary-based algorithm for text transformation to increase the data compression ratio when using standard compression tools. The basic idea of the new algorithm is to define a pattern for each word in a static dictionary by replacing all or most of the characters in the words of the dictionary by the most frequently used character in any text file. The proposed algorithm transforms any text file into another encrypted file with a size almost the same as that of the original text file but with different statistical properties. The new transformation method has been designed, implemented, and tested using Gutenburg Corpus. Generally, the output result has shown different levels of enhancements on different common standard data compression tools such as Arithmetic, Huffman, Bzip2, Gzip and WinZip. The compression performance of all common compression tools has been enhanced especially when the patterns of the transformed words passed through costless running length encoding (RLE) algorithm. On using Bzip2, the resultant output files produced about 76.75% as compression ratio with 1.88 as average code length. The final result is very promising and it could be enhanced more in case of applying dynamic dictionary-based text transformation technique.
The therapeutic relationship from an attachment theory perspective

The present study examined the view of the therapist as an attachment figure and the relationship between client adult attachment in close relationships and client attachment to the therapist27 clients in ongoing therapy were asked to complete measures of adult attachment andclient attachment to their therapists. In addition, five participants were interviewed with regard to their perceptions of their therapist and the therapeutic relationship.Quantitative analysis suggested that client attachment may be activated in the context of the therapeutic relationship. In particular, ‘Need for Approval’ was significantly associated with both ‘Fearful/Avoidant’ and ‘Preoccupied/Merger attachmentto the therapist’; ‘Preoccupation in Relationships’ was positively correlated to ‘Preoccupied/Merger attachment to therapist’. Qualitative findings further suggested that the therapist serves as an attachmentfigure for clients.The therapeutic relationship contains features of an attachment relationship and therapists are often seen by clients as a secure basis for exploration. In this context, thebehaviour that clients present in therapy is seen as meaningful and its exploration can contribute to the deconstruction and re-appraisal of internal working models of self andothers. Implications for the practice of counselling psychology are discussed.
Sustaining Superior Performance in Business Ecosystems: Evidence from Application Software Developers in the iOS and Android Smartphone Ecosystems

We study the phenomenon of business ecosystems in which platform firms orchestrate the functioning of ecosystems by providing platforms and setting the rules for participation by complementor firms. We develop a theoretical framework to explain how the structural and evolutionary features of the ecosystem may shape the extent to which participating complementor firms can sustain their superior performance. The structural feature, which we refer to as ecosystem complexity, is a function of the number of unique components or subsystems that interact with the complementor’s product. We incorporate the evolutionary features by considering the role of generational transitions initiated by platform firms over time as well as the role of complementors’ ecosystem-specific experience. Evidence from Apple’s iOS and Google’s Android smartphone ecosystems supports our arguments that higher ecosystem complexity helps app developers sustain their superior performance, and that this effect is stronger for more experienc.
Perceptual Biases in Relation to Paranormal and Conspiracy Beliefs

Previous studies have shown that one’s prior beliefs have a strong effect on perceptual decision-making and attentional processing. The present study extends these findings by investigating how individual differences in paranormal and conspiracy beliefs are related to perceptual and attentional biases. Two field studies were conducted in which visitors of a paranormal conducted a perceptual decision making task (i.e. the face / house categorization task; Experiment 1) or a visual attention task (i.e. the global / local processing task; Experiment 2). In the first experiment it was found that skeptics compared to believers more often incorrectly categorized ambiguous face stimuli as representing a house, indicating that disbelief rather than belief in the paranormal is driving the bias observed for the categorization of ambiguous stimuli. In the second experiment, it was found that skeptics showed a classical ‘global-to-local’ interference effect, whereas believers in conspiracy theories were characterized by a stronger ‘local-to-global interference effect’. The present study shows that individual differences in paranormal and conspiracy beliefs are associated with perceptual and attentional biases, thereby extending the growing body of work in this field indicating effects of cultural learning on basic perceptual processes.