Miracle-dz/UniFAR-FTUs huggingface dataset:
PERFORMA PERTUMBUHAN DAN KELULUSHIDUPAN IKAN NILA GIFT (Oreochromis niloticus) YANG DIBERI JUMLAH PAKAN YANG BERBEDA

Keberhasilan budidaya sangat ditentukan beberapa aspek, salah satunya adalah jumlah pakan. Pakan yang memiliki nilai nutrisi yang baik akan memberikan pertumbuhan yang baik bagi ikan nila gift. Pemberian jumlah pakan yang tepat merupakan suatu usaha untuk mencapai keberhasilan pertumbuhan ikan nila gift. Pemberian jumlah pakan yang kurang tepat mengakibatkan penurunan kualitas air. Tujuan dari penelitian ini adalah untuk mengkaji peforma pemberian jumlah pakan yang berbeda terhadap ikan nila gift ( O. Niloticus ) terhadap pertumbuhan dan kelulushidupan ikan nila gift. Ikan uji yang digunakan adalah benih ikan nila gift ( O. niloticus ) dengan bobot rata-rata 3,69±0,55g/ekor dan padat tebar 30 ekor/m 3 . P enelitian ini menggunakan metode deskrptif dengan 4 perlakuan dan 3 kali ulangan . Perlakuan dalam penelitian ini: A (150,44 g), B (175,42), C (200,48) dan D (225,38). Data yang diamati meliputi EPP, PER, RGR , SR dan kualitas air. Hasil penelitian menunjukkan bahwa pemberian jumlah pakan yang berbeda berpengaruh terhadap EPP, PER, RGR , SR . Nilai EPP terbaik yaitu pada perlakuan D 81,35±0,63%. Nilai PER terbaik y a itu pada perlakuan D 2,18±0,02%. Nilai RGR terbaik ya i tu perlakua n D 3,72±0,07%/hari. SR terbaik yaitu pada perlakuan D 96,67 %, . Kualitas air pada media pemeliharaan berada pada kisaran yang sesuai untuk budidaya ikan nila gift. The success of cultivation is determined some aspects, one of which is the amount of feed. Feed that has good nutritional value will provide good growth for the tilapia gift. Giving the right amount of feed is an effort to achieve the successful growth of tilapia gift. Incorrect feeding resulted in decreased water quality. The purpose of this study is to examine the performance of different feeding amounts to the indigo tilapia (O. Niloticus) to growth and survival of tilapia gift fish. The test fish used are Tilapia fish gift (O. niloticus) with average weight 3,69 ± 0,55g / tail and stocking stock 30 / m3. This research used the descriptive method with 4 treatments and 3 replications. The treatments in this study were: A (150,44 g), B (175,42), C (200,48) and D (225,38). Observed data include EPP, PER, RGR, SR and water quality. The result of the research shows that the different feeding level has the influence to EPP, PER, RGR, SR. The best value of EPP is on treatment D 81,35 ± 0,63%. The best PER value is at treatment D 2.18 ± 0.02%. The best RGR value is treatment D 3.72 ± 0.07% / day. The best SR is at treatment D 96,67%. Water quality on maintenance media is in the appropriate range for indigo tilapia gift. PERFORMA PERTUMBUHAN DAN KELULUSHIDUPAN IKAN NILA GIFT (Oreochromis niloticus) YANG DIBERI JUMLAH PAKAN YANG BERBEDA
THE CASE FOR CONVERTIBLES

Bond-Equity Hybrids Let Investors Keep Their Options Open Convertible securities are the chameleons of the investment world, offering investors both the growth potential of common stocks and the income offered by bonds. Issued by companies looking to raise capital, these hybrid investments are generally structured as some form of debt (bonds, debentures) or preferred shares with an embedded option that allows conversion into common shares under predetermined conditions.
Primary Malignant Lymphoma of the Breast: Clinicopathological Study of Nine Cases

Primary lymphoma of the breast is rare, accounting for 1.7 – 2.2% of extranodal lymphomas and 0.38 – 0.7% of non-Hodgkin's lymphomas (NHL). The aim of this study was to evaluate the clinicopathological features and treatment outcomes of patients with primary breast lymphomas (PBL). We conducted a retrospective review of the NHL cases diagnosed at Korea Cancer Center Hospital between 1989 and 2002. Nine (0.9%) of the 1,050 cases fulfilled the criteria for PBL. All patients were women (median age, 45 years) and usually presented with breast masses that had recently become enlarged. Six cases involved the breast alone (stage IE), whereas 3 cases also involved the ipsilateral axillary lymph nodes (stage IIE). Histopathologic studies revealed a diffuse large B cell lymphoma in 7 cases, marginal zone B cell lymphoma in 1 case, and small lymphocytic lymphoma in 1 case. Immunohistochemical analysis revealed a B-cell phenotype in all cases. There was no uniform approach to the treatment of PBL. Modified radical mastectomy and chemotherapy was performed in 4 cases, modified radical mastectomy and chemoradiotherapy was performed in 1 case, chemoradiotherapy alone, modified radical mastectomy alone, chemotherapy alone, and radiotherapy alone were performed in 1 case each. All cases achieved complete remission, but median overall survival was 12 months, showing very poor prognosis irrespective of the type of treatment modality.
Frequency of BCR-ABL fusion transcripts in Serbian patients with chronic myeloid leukemia.

PURPOSE The aim of this study was to analyze the occurrence of the most frequent BCR-ABL transcript variants (b3a2, b2a2 and e1a2) in Serbian patients with chronic myeloid leukemia (CML) and compare it with the occurrence reported in other populations. METHODS We analyzed peripheral blood and bone marrow samples of 136 Serbian patients with CML by RT-PCR and cytogenetic methods. RESULTS In 100 patients (73.5%) the b3a2 and in 34 (25%) the b2a2 forms of BCR-ABL were detected. One (0.75%) patient was BCR-ABL negative, but in lymphoblastic transformation he expressed the e1a2 [corrected] transcript of BCR-ABL. One (0.75%) patient displayed both b2a2 and b3a2 forms of BCR-ABL. Analysis of this group according to karyotype showed b3a2 predominance (79%) in patients with classic t(9;22); b2a2 was found in 20% and both b2a2 and b3a2 forms in 1%. In variant translocations b3a2 in 65% and b2a2 in 35% of the patients were detected. In contrast, the subgroup with normal karyotype expressed slight predominance of the b2a2 form (50%); b3a2 was found in 43% of the patients and one patient (7%) displayed e1a2. CONCLUSION Predominance of the b3a2 form in Serbian patients with CML is in concordance with other relevant investigations, conducted mostly on Caucasian ethnic groups, but in contrast to the study performed on the Mestizo ethnic group in Ecuador. Slight predominance of the b2a2 form was also noticed among the patients with normal karyotype.
Progress in the research on the mechanism of bone metastasis in lung cancer

Lung cancer is still the predominant cause of cancer-associated mortality worldwide. The bone metastasis of lung cancer brings great suffering to the patient. Previous advances have provided insights into the mechanism of bone metastasis. Previous research has investigated lung cancer stem cells and three steps were determined for the lung cancer cells to metastasize to the bone: i) Escaping from the primary tumor; ii) moving in the circulation; iii) colonizing in the bone. Key molecules are involved in each of these process. Although there is a close association and similarity, dynamic microenvironments affect these processes. The receptor activator of nuclear factor-κB (RANK)/RANKL axis serves a vital role in the regulation of the generation and activation of osteoclasts during the osteolytic lesion. However, the specific molecules for the lung cancer cells to metastasize to the bone require further research and exploration. The present study aimed to investigate the relative molecular mechanisms of bone metastasis in lung cancer in recent years, providing a general understanding about the features of lung cancer preferences to bone, and discussing other things that require investigation.
Detection of drug-resistant Mycobacterium tuberculosis from TB suspected diabetic patients by GeneXpert MTB/RIF method

Multidrug-resistant tuberculosis (MDR-TB) has become one of the major public health menace in the developing countries which have destructive consequences in immunocompromised patients. Rapid detection of such cases is indispensable to initiate the early and proper treatment of the infected individuals. Present study was conducted to determine the frequency of drug resistant Mycobacterium tuberculosis among the TB suspected diabetic patients employing GeneXpert MTB/RIF method. A total of 1311 sputum specimens were tested among which 154 (11.7%), 109 (8.3%) and 92 (7%) were found to carry Mycobacterium tuberculosis by GeneXpert, auramine O staining and Zeihl-Neelsen (Z-N) staining methods, consecutively. The relative positivity of the GeneXpert method was 40.3% and 29.2% higher than that of Z-N and auramine O staining methods. The sensitivity, specificity and accuracy of GeneXpert method were found to be higher when compared to these microscopic techniques. An estimation of 12.9% (n=132) of the positive cases was found among the diabetic patients (n=1027), whereas 7.7% (n=22) of the non-diabetic patients (n=284) showed positivity by GeneXpert method. Four (2.6%) among the MTB positive cases exhibited rifampicin resistance of which 3 were diabetic patients. DOI: http://dx.doi. org/10.3329/sjm.v4i1. 22754 Stamford Journal of Microbiology, Vol.4(1) 2014: 9-12
Metabolic profiles of biological aging in American Indians: The strong heart family study

Short telomere length, a marker of biological aging, has been associated with age-related metabolic disorders. Telomere attrition induces profound metabolic dysfunction in animal models, but no study has examined the metabolome of telomeric aging in human. Here we studied 423 apparently healthy American Indians participating in the Strong Family Heart Study. Leukocyte telomere length (LTL) was measured by qPCR. Metabolites in fasting plasma were detected by untargeted LC/MS. Associations of LTL with each metabolite and their combined effects were examined using generalized estimating equation adjusting for chronological age and other aging-related factors. Multiple testing was corrected using the q-value method (q<0.05). Of the 1,364 distinct m/z features detected, nineteen metabolites in the classes of glycerophosphoethanolamines, glycerophosphocholines, glycerolipids, bile acids, isoprenoids, fatty amides, or L-carnitine ester were significantly associated with LTL, independent of chronological age and other aging-related factors. Participants with longer (top tertile) and shorter (bottom tertile) LTL were clearly separated into distinct groups using a multi-marker score comprising of all these metabolites, suggesting that these newly detected metabolites could be novel metabolic markers of biological aging. This is the first study to interrogate the human metabolome of telomeric aging. Our results provide initial evidence for a metabolic control of LTL and may reveal previously undescribed new roles of various lipids in the aging process.
Initiation of ensemble data assimilation

The specification of the initial ensemble for ensemble data assimilation is addressed. The presented work examines the impact of ensemble initiation in the Maximum Likelihood Ensemble Filter (MLEF) framework, but is also applicable to other ensemble data assimilation algorithms. Two methods are considered: the first is based on the use of the Kardar-Parisi-Zhang (KPZ) equation to form sparse random perturbations, followed by spatial smoothing to enforce desired correlation structure, while the second is based on the spatial smoothing of initially uncorrelated random perturbations. Data assimilation experiments are conducted using a global shallow-water model and simulated observations. The two proposed methods are compared to the commonly used method of uncorrelated random perturbations. The results indicate that the impact of the initial correlations in ensemble data assimilation is beneficial. The root-mean-square error rate of convergence of the data assimilation is improved, and the positive impact of initial correlations is notable throughout the data assimilation cycles. The sensitivity to the choice of the correlation length scale exists, although it is not very high. The implied computational savings and improvement of the results may be important in future realistic applications of ensemble data assimilation.
Efficacy and safety of bortezomib plus dexamethasone therapy for refractory or relapsed multiple myeloma: once-weekly administration of bortezomib may reduce the incidence of gastrointestinal adverse events.

BACKGROUND To establish the clinical use of bortezomib with fewer adverse events, we retrospectively analyzed the efficacy and safety of bortezomib plus dexamethasone (BD) therapy for relapsed or refractory multiple myeloma. PATIENTS AND METHODS Patients received bortezomib (1.3 mg/m2) as an intravenous bolus on days 1, 4, 8 and 11 in a 3-week cycle (twice-weekly administration), or on days 1, 8, 15 and 22 in a 5-week cycle (once-weekly administration). Dexamethasone (20 mg) was given on the day of and day after bortezomib treatment. RESULTS From January 2007 to July 2010, 22 patients began to receive BD therapy. Initially, bortezomib was administered twice-weekly, but some severe adverse events developed; therefore, from January 2008, bortezomib was administered twice-weekly for the first two courses, followed by once-weekly for the subsequent courses. Patients who were expected to have severe adverse events beforehand were treated initially with once-weekly administration. Of the 22 patients, 14 were treated with twice-weekly followed by once-weekly administration, five with only twice-weekly administration and three with only once-weekly administration. Seventeen patients (77.3%) achieved at least partial response, including three with complete response and seven with very good partial response. The median progression-free survival and the median overall survival of 22 patients were 512 days and not reached, respectively. The median progression-free survival and the median overall survival of 17 patients who received at least one course of once-weekly administration were 615 days and not reached, respectively. The most frequent ≥grade 3 adverse events with twice-weekly administration were gastrointestinal, especially paralytic ileus and constipation. Among seven patients who developed ≥grade 3 gastrointestinal adverse events with twice-weekly administration, all four patients changed the schedule to once-weekly were able to continue BD therapy. CONCLUSION Once-weekly administration of bortezomib in BD therapy may reduce the incidence of gastrointestinal adverse events without reducing the clinical efficacy of this therapy for refractory or relapsed multiple myeloma.
Comments on "A generalized LMI-based approach to the global asymptotic stability of delayed cellular neural networks"

In this letter, we point out that the linear matrix inequality (LMI)-based criterion obtained in the above paper for the global exponential stability of the delayed neural networks can be simplified to a simpler but equivalent form and, thus, show that it is not necessary to have such complex form of condition in the above paper. As a result, we also answer the question raised by the author of the above paper.
Identification of Naturally Processed Hepatitis C Virus-Derived Major Histocompatibility Complex Class I Ligands

Fine mapping of human cytotoxic T lymphocyte (CTL) responses against hepatitis C virus (HCV) is based on external loading of target cells with synthetic peptides which are either derived from prediction algorithms or from overlapping peptide libraries. These strategies do not address putative host and viral mechanisms which may alter processing as well as presentation of CTL epitopes. Therefore, the aim of this proof-of-concept study was to identify naturally processed HCV-derived major histocompatibility complex (MHC) class I ligands. To this end, continuous human cell lines were engineered to inducibly express HCV proteins and to constitutively express high levels of functional HLA-A2. These cell lines were recognized in an HLA-A2-restricted manner by HCV-specific CTLs. Ligands eluted from HLA-A2 molecules isolated from large-scale cultures of these cell lines were separated by high performance liquid chromatography and further analyzed by electrospray ionization quadrupole time of flight mass spectrometry (MS)/tandem MS. These analyses allowed the identification of two HLA-A2-restricted epitopes derived from HCV nonstructural proteins (NS) 3 and 5B (NS31406–1415 and NS5B2594–2602). In conclusion, we describe a general strategy that may be useful to investigate HCV pathogenesis and may contribute to the development of preventive and therapeutic vaccines in the future.
The Population of BzK-selected ULIRGs at z ~ 2

We investigate the multiwavelength emission of BzK-selected star-forming galaxies at z ~ 2 in the Great Observatories Origins Deep Survey (GOODS) North region. Most (82%) of the sources are individually detected at 24 μm in the Spitzer MIPS imaging, and one-fourth (26%) in the VLA radio data. Significant detections of the individually undetected objects are obtained through stacking in the radio, submillimeter, and X-ray domains. The typical star-forming galaxy with stellar mass ~1011 M☉ at z = 2 is an ultraluminous infrared galaxy (ULIRG), with LIR ~ (1-2) × 1012 L☉ and star formation rate SFR ≈ 200-300 M☉ yr-1, implying a comoving density of ULIRGs at z = 2 at least 3 orders of magnitude above the local one. SFRs derived from the reddening-corrected UV luminosities agree well, on average, with the longer wavelength estimates. The high 24 μm detection rate suggests a relatively large duty cycle for the BzK star-forming phase, which is consistent with the available independent measurements of the space density of passively evolving galaxies at z > 1.4. If the IMF at z = 2 is similar to the local one, and in particular if it is not top-heavy, this suggests that a substantial fraction of the high-mass tail (≳1011 M☉) of the galaxy stellar mass function was completed by z ≈ 1.4.
Evidence of Foam Sclerotherapy in the Treatment of
 Recurrent Varicose Veins

Purpose Efficacy and safety of ultrasound-guided foam sclerotherapy (UGFS) for the treatment of primary venous disease is proven, but the main application field of UGFS remains the treatment of recurrent varicose veins (RVV). The aim of this study is to determine the extent to which this treatment indication is evidence-based. Methods In PubMed and other publicly accessible databases, literature was reviewed until June 2018 and checked for relevance. The focus was on results with regard to anatomical success as well as clinical success and perception by patients. Results Several observational studies comprised a subgroup of RVV patients, but systematic stratification for RVV patients were only rarely performed. In most of these studies including the few reports specifically investigating RVV patients anatomical success as the primary outcome measure revealed similar results compared to primary interventions and favourable results in patients with neovascularization. Data on clinical outcome and patient perception were inconclusive due to low study numbers and insufficient stratification. Complications in RVV patients were rare. Conclusion Although the advantages inherent to the UGFS principle provide a strong rationale that this method best meets the requirements of the specific RVV characteristics, concept and previous observations should be supported by more evidence. Systematic studies in RVV patients with sufficient sample size are required.
Stereotypical hand movements in 144 subjects with Rett syndrome from the population‐based Australian database

Stereotypic hand movements are a feature of Rett Syndrome but few studies have observed their nature systematically. Video data in familiar settings were obtained on subjects (n = 144) identified from an Australian population‐based database. Hand stereotypies were demonstrated by most subjects (94.4%), 15 categories were observed and midline wringing was seen in approximately 60% of subjects. There was a median of two stereotypies per subject but this number decreased with age. Clapping and mouthing of hands were more prevalent in girls younger than 8 years and wringing was more prevalent in women 19 years or older. Clapping was commoner in those with p.R306C and early truncating mutations, and much rarer in those with p.R106W, p.R270X, p.R168X, and p.R255X. Stereotypies tended to be less frequent in those with more severe mutations. Otherwise, there were no clear relationships between our categories of stereotypies and mutation. Approximately a quarter each had predominantly right and left handed stereotypies and for the remaining half, no clear laterality was seen. Results were similar for all cases and when restricted to those with a pathogenic mutation. Hand stereotypies changed with increasing age but limited relationships with MECP2 mutations were identified. © 2009 Movement Disorder Society
Customers' Adoption of Internet Banking Service: An Empirical Examination of the Theory of Planned Behavior in Yemen

The explosion of Internet usage and the great funding initiatives in electronic banking have taken the attention of researchers towards Internet banking. At the beginning, the conventional focus of Internet banking research has been on technological infrastructure, but this is now shifting to user-focused research. Although millions of dollars have been paid to invest in the Internet banking services, reports have shown that potential users may not use these services. A great deal of research has been conducted in various countries to determine the factors that influence acceptance of Internet banking. However, these studies have not taken into account emotional dimension that related to individuals’ technology readiness. In addition, there is still very few research has been conducted on the Internet banking in Arab countries in general, and Yemen, in particular. Therefore, this study attempts to fill this gap via applyingthe theory of planned behavior (TPB) in developing countries (i.e., Yemen). Based on a sample of 1286bank customers, structural equation modeling was applied to data analysis. The results strongly support the TPB model. Attitude, subjective norm and perceived behavioral control have a significant positive effect on individuals’ intention to adopt the Internet banking service.