Miracle-dz/UniFAR-FTUs huggingface dataset:
An Observation Tool for Self-Regulatory Events in Music Teaching (T-SREM):Development and Testing of a Video Coding Tool for Music Lessons

Many young people embark on music lessons during childhood, but few pursue such instruction beyond a few years’ time, thus missing out on the life-long pleasure of making music for oneself. Problems with children’s self-regulation of learning, particularly the three-phase cycle of forethought, performance, and reflection proposed by Zimmerman (2000, 2006, 2008, 2011), may influence the abandonment of formal music lessons, as suggested by the research of McPherson and his colleagues (McPherson et al., 2012; McPherson & Renwick, 2011; McPherson, Nielsen, & Renwick, 2013; McPherson & Zimmerman, 2011). As part of a larger project examining self-regulation and music learning in the digital age, an observation tool for coding self-regulatory events in music lessons was developed. The tool uses categories from Zimmerman’s self-regulatory cycle of learning to code verbal and nonverbal interactions and behaviours of teachers and students in videotaped music lessons. The iterative process of the tool’s development is presented and discussed, including an analysis of issues around using videotaped material. Results from a pilot test, in which researchers coded 12.9 hours of videotaped lessons from four music teachers in the Greater Toronto Area, are given. Patterns in self-regulated learning that emerged during the pilot test are explored, suggestions for triangulating the results with other project data are presented, and suggestions for further research are given.
Children's use of intonation in reference and the role of input

Studies of children’s use of intonation in reference are few in number but are diverse in terms of theoretical frameworks and intonational parameters. In the current review, I present a re-analysis of the referents in each study, using a three-dimension approach (i.e., referential givenness-newness, relational givenness-newness, contrast), discuss the use of intonation at two levels (phonetic, phonological), and compare findings from different studies within a single framework. The patterns stemming from these studies may be limited in generalisability but can serve as initial hypotheses for future work. Furthermore, to shed light on the role of input in the acquisition of intonational encoding of referents, I examine caregivers’ use of intonation in reference in infant direct speech. In addition, I discuss how future research can advance our knowledge of these issues.
Early Hedgehog signaling from neural to oral epithelium organizes anterior craniofacial development

Hedgehog (Hh) signaling plays multiple roles in the development of the anterior craniofacial skeleton. We show that the earliest function of Hh is indirect, regulating development of the stomodeum, or oral ectoderm. A subset of post-migratory neural crest cells, that gives rise to the cartilages of the anterior neurocranium and the pterygoid process of the palatoquadrate in the upper jaw, condenses upon the upper or roof layer of the stomodeal ectoderm in the first pharyngeal arch. We observe that in mutants for the Hh co-receptor smoothened (smo) the condensation of this specific subset of crest cells fails, and expression of several genes is lost in the stomodeal ectoderm. Genetic mosaic analyses with smo mutants show that for the crest cells to condense the crucial target tissue receiving the Hh signal is the stomodeum, not the crest. Blocking signaling with cyclopamine reveals that the crucial stage, for both crest condensation and stomodeal marker expression, is at the end of gastrulation - some eight to ten hours before crest cells migrate to associate with the stomodeum. Two Hh genes, shh and twhh, are expressed in midline tissue at this stage, and we show using mosaics that for condensation and skeletogenesis only the ventral brain primordium, and not the prechordal plate, is an important Hh source. Thus, we propose that Hh signaling from the brain primordium is required for proper specification of the stomodeum and the stomodeum, in turn, promotes condensation of a subset of neural crest cells that will form the anterior neurocranial and upper jaw cartilage.
DNA mismatch correction.

PERSPECTIVES ANDUMMARY 435 BIOLOGY OFMISMATCH ORRECTION 437 Evidence for Mismatch Processing in Vivo 437 Postreplication Repair of Biosynthetic Errors 438 dam-Independent Mismatch Correction in E. coli 442 Mismatch Specificity 444 STRUCTURES OF BASE PAIR MISMATCHES 445 Extent of DNA Helix Disruption by Noncomplementary Bases: Melting Behavior and Single-Strand Nuclease Sensitivity 446 G-T and A-C Transition Mismatches 448 Purine-Purine and Pyrimidine-Pyrimidine Transversion Mismatches 454 Insertion~Oeletion Mispairs 456 Implications for Mismatch Recognition 457 MISMATCH CORRECTION IN VITRO 458 Requirements for Methyl-Directed Mismatch Correction in Vitro 458 Proteins Required for dam-Directed Mismatch Repair 459 Repair DNA Synthesis Associated with Methyl-Directed Mismatch Correction . 461 Models for Methyl-Directed Mismatch Correction 461
Resisting stereotypes: Evaluations of peer group exclusion

Title of Dissertation: RESISTING STEREOTYPES: EVALUATIONS OF PEER GROUP EXCLUSION Kelly Lynn Sara Mulvey, Doctor of Philosophy, 2013 Dissertation directed by: Professor Melanie Killen, Department of Human Development and Quantitative Methodology Gender stereotypes permeate peer groups, often functioning as the norms, or conventions, which contribute to group identity. Little is known about the conditions under which children will resist the norms of their peer groups, including norms that reflect stereotypic expectations. This study investigated this issue by measuring how children responded to members of their gender groups who disagreed with the group about gender stereotyped aggressive behaviors (female stereotype: relational aggression, male stereotype: physical aggression) as well as about social activities (football and ballet). Social domain theory as well as social identity theory provided the basis for formulating the design and the hypotheses. It was expected that children and adolescents would expect their peers to challenge the group, but that they would be concerned about the consequences of challenging the group in terms of social exclusion. Participants (N = 292, 9-10 and 13-14 years of age) assessed members of same-gender peer groups who disagreed with their group. The findings revealed that children and adolescents generally expected that their peers will resist the group’s gender stereotypic norms surrounding aggression, but that this may be more difficult for boys when voicing their counterstereotypic opinions. Further, participants themselves believed that they would be less influenced by gender stereotypes than would their peers. They asserted that they would, individually, be more likely to resist the group than they expect a peer would be. This research also revealed important barriers to resisting the group. Specifically, children and adolescents expected that group members who dissent from or resist the group are likely to be excluded from the group for voicing their dissent. This stands in sharp contrast to much research which indicates that children are not accepting of exclusion. Rejecting the behavior of one’s peer group, especially when that behavior has negative intrinsic consequences for others, is a key step towards changing the culture of peer groups more broadly. However, the findings indicate that, while children and adolescents are optimistic about their peers challenging the peer group, they also see exclusion as a very real possibility and consequence for such resistance. RESISTING STEREOTYPES: EVALUATIONS OF PEER GROUP EXCLUSION
Prognostic involvement of nucleophosmin mutations in acute myeloid leaukemia.

Nucleophosmin (NPM1) is a protein of highly conserved nature which works as a molecular chaperone and is mostly found in nucleoli. NPM also involved in the maturation of preribosomes and duplication of centrosomes. Furthermore, it is also active in control and regulation of the ARF-p53 tumor suppressor pathway. A high rate of incidence and prognostic involvement is reported by various authors in AML patients. In AML it behaves as a favorable prognostic marker. NPM mutations are more frequently associated with normal-karyotype AML and are usually absent in patients having abnormal or poor cytogenetic. NPM mutations are not frequent in other hematopoietic tumors . Two main types of mutations have been described to date. Both of these cause abnormal cytoplasmic localization of NPM1. Their high incidence rate in normal karyoptype and their favorable nature make those mutations hot spot or front face mutations which should be checked before treatment starts.
Ontogeny and Functions of Central Nervous System Macrophages

Microglia, the only nonneuroepithelial cells found in the parenchyma of the CNS, originate during embryogenesis from the yolk sac and enter the CNS quite early (embryonic day 9.5–10 in mice). Thereafter, microglia are maintained independently of any input from the blood and, in particular, do not require hematopoietic stem cells as a source of replacement for senescent cells. Monocytes are hematopoietic cells, derived from bone marrow. The ontogeny of microglia and monocytes is important for understanding CNS pathologies. Microglial functions are distinct from those of blood-derived monocytes, which invade the CNS only under pathological conditions. Recent data reveal that microglia play an important role in managing neuronal cell death, neurogenesis, and synaptic interactions. In this article, we discuss the physiology of microglia and the functions of monocytes in CNS pathology. We address the roles of microglia and monocytes in neurodegenerative diseases as an example of CNS pathology.
Binding of measles virus to membrane cofactor protein (CD46): importance of disulfide bonds and N-glycans for the receptor function

Two cellular proteins, membrane cofactor protein (MCP) and moesin, were reported recently to be functionally associated with the initiation of a measles virus infection. We have analyzed the interaction of measles virus with cell surface proteins, using an overlay binding assay with cellular proteins immobilized on nitrocellulose. Among surface-biotinylated proteins from a human rectal tumor cell line (HRT), measles virus was able to bind only to a 67-kDa protein that was identified as MCP. The virus recognized different isoforms of MCP expressed from human (HRT and HeLa) and simian (Vero) cell lines. The binding of measles virus to MCP was abolished after cleavage of the disulfide bonds by reducing agents as well as after enzymatic release of N-linked oligosaccharides. By contrast, removal of sialic acid or O-linked oligosaccharides did not affect the recognition of MCP measles virus. These data indicate that the receptor determinant of MCP is dependent on a conformation of the protein that is maintained by disulfide bonds and N-glycans present in the complement binding domains. Our results are consistent with a role of MCP as primary attachment site for measles virus in the initial stage of an infection. The functional relationship between MCP and moesin in a measles virus infection is discussed.
A collagenated porcine bone substitute for augmentation at Neoss implant sites: a prospective 1-year multicenter case series study with histology.

BACKGROUND The presence of localized defects and/or small amounts of bone below the maxillary sinus is a common finding, which may compromise implant placement. There is therefore a need for predictable techniques for bone augmentation in such situations. PURPOSE The study aims to clinically and histologically evaluate a porcine bone (PB) substitute used for augmentation of the alveolar crest or the maxillary sinus floor prior to or in conjunction with implant placement. MATERIALS AND METHODS Nineteen patients were treated with a porcine bone substitute and barrier membranes (OsteoBiol, Tecnoss Dental, Turin, Italy) for lateral bone augmentation (Group 1a) and healing of bone defects (Group 1b) or for augmentation of the maxillary sinus floor using either a replaceable (Group 2a) or an infractured bone window (Group 2b). A total of 34 implants (Neoss Ltd., Harrogate, UK) were placed in conjunction or 5 to 7 months after the procedure. Implants were followed with implant stability measurements at placement and abutment connection, and with intraoral radiographs at abutment connection and after at least 1 year of loading. A biopsy for histology and morphometry was taken at the first reentry operation. RESULTS All but one of the procedures was successful (94.7%) as one maxillary sinus procedure (Group 2a) resulted in insufficient bone for implant placement. One of the 34 implants failed, giving an implant survival rate of 97.1% after 1 year. Implant stability measurements showed a mean stability of 71.9 ± 7.7 implant stability quotient (ISQ) at placement, which significantly increased to 75.3 ± 6.8 ISQ at abutment connection (p = .03). The average bone loss was 0.5 ± 0.7 mm during 1 year. Histology revealed new bone formation at the PB surface, which formed bridges between particles and between particles and preexisting bone. The presence of scalloped resorption lacunae and new osteons inside the particles indicated ongoing resorption/remodeling of the particles. The histomorphometric analyses showed that the total specimen area consisted of, in average, 56.5 ± 15.7% mineralized tissue of which 24.8 ± 13.9% of the total area was PB particles. CONCLUSION This study showed good clinical results when using a PB substitute and barrier membranes for augmentation of the alveolar crest and maxillary sinus. Histology revealed bone condensation properties and indicated that the material can be resorbed with time.
Dynamic Load Balancing With Handover in Hybrid Li-Fi and Wi-Fi Networks

In this paper, a hybrid network combining light fidelity (Li-Fi) with a radio frequency (RF) wireless fidelity (Wi-Fi) network is considered. An additional tier of very small Li-Fi attocells which utilize the visible light spectrum, offers a significant increase in the wireless data throughput in an indoor environment, while at the same time providing room illumination. Importantly, there is no interference between Li-Fi and Wi-Fi. A Li-Fi attocell covers a significantly smaller area than a Wi-Fi access point (AP). This means that even with a moderate user movement a large number of handover between Li-Fi attocells can occur, and this compromises the system throughput. Dynamic load balancing (LB) can mitigate this issue so that the quasi-static users are served by Li-Fi attocells, while moving users are served by a Wi-Fi AP. However, due to the user movement, local overload situations may occur which prevent handover, leading to a lower throughput. This research studies LB in a hybrid Li-Fi/Wi-Fi network by taking into account user mobility and handover signalling overheads. Furthermore, a dynamic LB scheme is proposed, where the utility function considers system throughput and fairness. In order to better understand the handover effect on the LB, the service areas of different APs are studied, and the throughput of each AP by employing the proposed LB scheme is analyzed.
Prefrontal Neural Activity When Feedback Is Not Relevant to Adjust Performance

It has been shown that the rostral cingulate zone (RCZ) in humans uses both positive and negative feedback to evaluate performance and to flexibly adjust behaviour. Less is known on how the feedback types are processed by the RCZ and other prefrontal brain areas, when feedback can only be used to evaluate performance, but cannot be used to adjust behaviour. The present fMRI study aimed at investigating feedback that can only be used to evaluate performance in a word-learning paradigm. One group of volunteers (N = 17) received informative, performance-dependent positive or negative feedback after each trial. Since new words had to be learnt in each trial, the feedback could not be used for task-specific adaptations. The other group (N = 17) always received non-informative feedback, providing neither information about performance nor about possible task-specific adaptations. Effects of the informational value of feedback were assessed between-subjects, comparing trials with positive and negative informative feedback to non-informative feedback. Effects of feedback valence were assessed by comparing neural activity to positive and negative feedback within the informative-feedback group. Our results show that several prefrontal regions, including the pre-SMA, the inferior frontal cortex and the insula were sensitive to both, the informational value and the valence aspect of the feedback with stronger activations to informative as compared to non-informative feedback and to informative negative compared to informative positive feedback. The only exception was RCZ which was sensitive to the informational value of the feedback, but not to feedback valence. The findings indicate that outcome information per se is sufficient to activate prefrontal brain regions, with the RCZ being the only prefrontal brain region which is equally sensitive to positive and negative feedback.
Effects of Floor Heating and Litter Quality on the Development and Severity of Foot Pad Dermatitis in Young Turkeys

SUMMARY. Actions concerning animal health in turkey production are coming more and more to the fore. Litter quality has a great impact on the bird's health and welfare. This study aimed at evaluating the effects of using floor heating, different litter materials, and exposure to litter with a “critical moisture content” of 35% for 16 or 24 hr/day on the severity of foot pad dermatitis (FPD), a widespread disease in fattening turkeys. Four groups of 2-wk-old female turkeys, with 20 birds in each, were reared during 3 wk. All turkeys were fed a commercial pellet diet ad libitum. The first two groups were kept on wood shavings (35% moisture) without and with floor heating. The other two groups were housed on lignocellulose (Soft Cell®) of 35% moisture without and with floor heating. In each group, half of the birds were housed for 8 hr/day in adjacent separate boxes where the litter was kept clean and dry throughout the experimental period. Foot pads were assessed weekly for external and at day 35 for histopathologic scoring (scores: 0 = healthy; 7 = ulcer). At day 14 each bird had normal and healthy foot pads. The results indicate that using floor heating resulted in significantly lower FPD scores (0.8 ± 0.2) compared to groups without floor heating (2.0 ± 0.8). Using lignocellulose as a litter material resulted in significantly lower histopathologic FPD scores (1.4 ± 0.7) compared with wood shavings (1.7 ± 0.8). In all birds housed on dry litter for 8 hr/day, significantly lower FPD scores were found compared to birds housed on wet litter for 24 hr. In conclusion, using floor heating, even with wet litter (35% moisture), independent of the litter type, resulted in reduced severity of FPD compared to those birds housed in pens without using floor heating. Additionally, using lignocellulose as a litter material resulted in lower FPD compared with wood shavings. Keeping litter dry and “warm” could be achieved by using floor heating, which is considered a practical step to enhance animal health and welfare.
Factors Associated With Caregiver Burden Among Caregivers of Children With Cerebral Palsy in Sri Lanka

A cross-sectional study was conducted among 375 caregivers of children with cerebral palsy attending a tertiary care setting in Sri Lanka, to identify factors associated with caregiver burden. Caregiver burden was defined as “caregiver’s response to various stressors associated with caregiving” and was measured using Caregiver Difficulties Scale (CDS), developed specifically for this purpose. Multivariate linear regression was used to assess associations between sociodemographic, stressor, and coping factors and caregiver burden; and to examine whether coping reduces the effect of stressors on burden. Low income, rural residence, male sex, and number of functional deficits of the disabled child correlated significantly with higher caregiver burden, while spousal support correlated with lower burden. Seeking social support reduced the increased burden associated with greater functional impairments. Psychosocial interventions focused on evaluating and improving social support for caregivers may help families at high risk for caregiver distress, to minimize negative outcomes.
Ionization, shocks and evolution of the emission‐line gas of distant 3CR radio galaxies

An analysis of the kinematics and ionization state of the emission-line gas of a sample of 14 3CR radio galaxies with redshifts z∼1 is carried out. The data used for these studies, deep long-slit spectroscopic exposures from the William Herschel Telescope, are presented in an accompanying paper. It is found that radio sources with small linear sizes (≲150 kpc) have lower ionization states, higher emission-line fluxes and broader line widths than larger radio sources. An analysis of the low-redshift sample of Baum et al. demonstrates that radio galaxies at low redshift show similar evolution in their velocity structures and emission-line ratios from small to large radio sources. The emission-line ratios of small radio sources are in agreement with theoretical shock ionization predictions, and their velocity profiles are distorted. Together with the other emission-line properties, this indicates that shocks associated with the radio source dominate the kinematics and ionization of the emission-line gas during the period that the radio source is expanding through the interstellar medium. Gas clouds are accelerated by the shocks, giving rise to the irregular velocity structures observed, whilst shock compression of emission-line gas clouds and the presence of the ionizing photons associated with the shocks combine to lower the ionization state of the emission-line gas. By contrast, in larger sources the shock fronts have passed well beyond the emission-line regions; the emission-line gas of these larger radio sources has much more settled kinematical properties, indicative of rotation, and emission-line ratios consistent with the dominant source of ionizing photons being the active galactic nucleus. This strong evolution with radio size of the emission-line gas properties of powerful radio galaxies mirrors the radio size evolution seen in the nature of the optical–ultraviolet continuum emission of these sources, implying that the continuum alignment effect is likely to be related to the same radio source shocks.
Living Amidst Consolation in the Presence of God Perceptions of Consolation Among the Oldest Old: The Umeå 85+ Study

ABSTRACT This study describes how 90-year-olds and older people perceive consolation. Qualitative Content analysis of 49 interviews revealed four categories: consolation by God; consolation from others; consolation from self; and consolation from things, which were present in two themes. The theme “Living amidst consolation in the presence of God” was a core theme and expresses consolation as self-evident and based on a relation to God, others, self, and things. The theme “Seeking consolation,” expresses consolation from self, others, things, or God. Interviewees in some cases regretted that they had no religious faith. Reasonably, most interviewees referred to religious consolation, as religion had been so closely connected with the word “consolation” all their lives.