Miracle-dz/UniFAR-FTUs huggingface dataset:
Gender effects and sexual-orientation impact on androstadienone-evoked behavior and neural processing

In humans, the most established and investigated substance acting as a chemosignal, i.e., a substance that is excreted from the body, is 4,16-androstadien-3-one (AND). AND, which is found in sweat and saliva, is known to be responsible for influencing several variables, such as psychophysiological status, behavior, as well as cortical processing. The aim of the present review is to give insight into the variety of AND effects, with special regard to specific cross-sexual characteristics of this putative human chemosignal, emphasizing the neural activation patterns and factors such as contextual conditions. This review highlights the importance of including those contributing factors into the analysis of behavioral as well as brain-related studies.
Numerical abilities of grey parrots: Comparisons with apes and children

Do humans and nonhumans share numerical and perceptual abilities? Some researchers argue that nonhumans, lacking human language, possess exact understanding only of quantities up to about 4. Animals trained in human communication systems might, however, be more advanced. ALEX, a Grey parrot, could, for example, quantify sets of ≦8 items (including heterogeneous subsets) using vocal English labels, comprehend these labels fully, sum small quantities, and had a zero-like concept. He understood number symbols as abstract representations of real-world collections, in ways comparing favorably to those of apes and young human children. He appeared to learn in ways more similar to humans than apes.
How large are the differences - really ? Self-reported long-standing illness among working class and middle class men

Social inequalities in health are regularly found in health interview surveys, but it has been doubted whether respondents’ self-reported morbidity can accurately describe social class differences in health. Two hypotheses are current: members of the working class are commonly more preoccupied with their illnesses, and overreport them, compared with those of the middle class: secondly, the latter are more sensitive to their illnesses, have a better chance of getting them diagnosed, and consequently claim a wider array of illnesses in comparison with the former. This paper analyses answers to questions about long-standing illness from working class and middle class men, aged 25–64, in Norwegian surveys during the 1980s. Working class respondents experience their illnesses as more serious. An analysis of diagnostic categories of the illnesses of both sets of respondents indicates that this subjective experience is realistic. The hypothesis that a high level of psychological malaise among working class men produces a tendency to somatise psycho-social stress is not supported. The paper concludes that social inequalities in morbidity as shown by self-reported long-standing illness will often underestimate true class differences.
The Direction of Movement of Machine Controls

Experiments are described in which the relation between the direction of movement of a control and display was varied in order to determine what relationships are likely to cause least confusion to the operator of a machine. Two different types of task were used: a task consisting of intermittent stimuli whose rate of presentation could be varied, and a continuous pursuit task. It is found that accuracy of performance varies with the degree of remoteness of the directional relationship from those met in everyday life, with the complexity of the task, with the ability of the subject, and there is some indication that under certain Conditions it may vary with the breadth of his attention. Awareness of the response aspect of the situation in these simple sensori-motor tasks, it is suggested, although necessary in the early stages of learning, may be associated in the later stages with confusion and error.
A ReRAM-based non-volatile flip-flop with sub-VT read and CMOS voltage-compatible write

The total power budget of Ultra-Low Power (ULP) VLSI Systems-on-Chip (SoCs) is often dominated by the leakage power of embedded memories and pipeline registers, which typically cannot be power-gated during sleep periods as they need to retain data and program state, respectively. On the one hand, supply voltage scaling down to the near-threshold (near-VT) or even to the sub-threshold (sub-VT) domain is a commonly used, efficient technique to reduce both leakage power and active energy dissipation. On the other hand, emerging CMOS-compatible device technologies such as Resistive Memories (ReRAMs) enable non-volatile, on-chip data storage and zero-leakage sleep periods. For the first time, we present a ReRAM-based non-volatile flip-flop which is optimized for sub-VT operation. Writing to the ReRAM devices works with a CMOS-compatible supply voltage. Thanks to near-VT and sub-VT operation and as compared to the write energy, which depends on the ReRAM technology, the read consumes only 5.4% of the total read+write energy. Monte Carlo simulations accounting for parametric variations in both the MOS transistors and the ReRAM devices confirm reliable data restore operation from the ReRAM devices at a sub-VT voltage as low as 400 mV, and a standard deviation of up to 5% of the nominal value of the ReRAM resistance.
Habilidades matemáticas iniciais em crianças surdas e ouvintes

This study investigated the understanding of mathematical procedures and concepts by deaf pre-school children. There are few studies centered on the development of Mathematical concepts and procedures by deaf pre-school children and these studies suggest that deaf children have difficulty learning number sequences. However, there is no conclusive evidence regarding the causes. The results of this study show that differences in achievement between deaf and hearing children are related to linguistic demands. Therefore, deaf children have more difficulty in tasks with higher linguistic demand. Implications for the role of language in concept formation are discussed and supported by the data from this study.
Patterns of Social Support in the Middle Childhood to Early Adolescent Transition: Implications for Adjustment

Children's social networks often include close family members, extended family members, and friends, but little is known about interindividual differences in the patterning of support from these sources. In this study, we used person-oriented analyses to differentiate patterns of support for children undergoing the transition to adolescence. Social network and adjustment data were collected for an ethnically diverse sample of 691 fourth- and sixth-grade children, with a two-year follow-up. Cluster analyses identified one pattern of support from both close family members and friends, a second pattern of support from both close and extended family members, and a third pattern of support primarily from close family members alone. Participants receiving support from close family in combination with either extended family or friends were better adjusted than were those without multiple support resources. The results suggest that a meaningful typology of children's social networks can be developed.
Combining contour and shape primitives for object detection and pose estimation of prefabricated parts

Man-made objects such as mechanical construction parts can typically be described as a composition of shape primitives like cylinders, planes, cones and spheres. We propose a robust method for the detection and pose estimation of such objects in 3D point clouds. Our main contribution is to enhance a probabilistic graph-matching approach that detects objects using 3D shape primitives with distinct 2D primitives such as circular contours. With this extension, our method copes with difficult occlusion situations and can be applied for object manipulation in complex scenarios such as grasping from a pile or bin-picking. We demonstrate the performance of our approach in a comparison with a state-of-the-art feature-based method for objects of generic shape and a primitive-based approach using only 3D shapes and no contours.
Utterance modifiers and universals of grammatical borrowing

Members of a functional category that I tentatively call utterance modifiers are the most vulnerable items to contact-related linguistic change in grammar. Utterance modifiers regulate linguistic-mental processing activities that can be attributed to a grammar of directing. Bilinguals, when faced with the tension of choosing among the systems at their disposal in what is a highly automaticized operation, are tempted to reduce the overt representation of the grammar of directing to just one set of elements. Preference is given to the pragmatically dominant language. Contact-related change in the area of utterance modifiers is therefore not due to lack of equivalent functions in the indigenous language, nor is it due to the prestige effect that the integration of L2 items may have on the overall flavor of the discourse. Rather, I attribute synchronic variation in the speech of bilinguals to the cognitive pressure exerted on them to draw on the resources of the pragmatically dominant language for situative, gesturelike discourse-regulating purposes, and the diachronic change that arises from such variation to the establishment of a permanent licensing for speakers to do so
Adaptive record extraction from web pages

We describe an adaptive method for extracting records from web pages. Our algorithm combines a weighted tree matching metric with clustering for obtaining data extraction patterns.We compare our method experimentally to the state-of-the-art, and show that our approach is very competitive for rigidly-structured records (such as product descriptions) and far superior for loosely-structured records (such as entrieson blogs).
Role of GTP-binding proteins in the regulation of mammalian cardiac chloride conductance

Beta-Adrenoceptor agonists activate a time- and voltage-independent Cl- conductance in mammalian cardiac myocytes. To characterize the cellular signaling pathways underlying its regulation, wide-tipped pipettes fitted with a pipette perfusion device were used to record whole-cell current and to introduce nucleotides to the interior of guinea pig ventricular myocytes. Replacement of pipette GTP with GDP beta S prevented activation of the Cl- conductance by Iso, suggesting a requirement for G protein turnover. With GTP in the pipette, the effect of Iso could be abolished by the beta-adrenoceptor antagonist propranolol, and mimicked by histamine or forskolin. These actions of Iso and forskolin are mediated exclusively via cAMP-dependent protein kinase (PKA), because (a) maximal activation of the Cl- conductance by forskolin or pipette cAMP occluded the effect of Iso, and (b) switching to pipette solution containing a synthetic peptide inhibitor (PKI) of PKA completely abolished the Cl- conductance activated by Iso and prevented the action of forskolin, but had no further effect. These results argue against basal activation of the Cl- conductance, and make it extremely unlikely that the stimulatory G protein, Gs, has any direct, phosphorylation-independent influence. The muscarinic receptor agonists acetylcholine (ACh) and carbachol diminished, in a reversible manner, Cl- conductance activated by Iso or forskolin, but not that elicited by cAMP. The muscarinic inhibition was abolished by replacing pipette GTP with GDP beta S, or by preincubating cells with pertussis toxin (PTX), and was therefore mediated by an inhibitory G protein, presumably Gi, influencing adenylyl cyclase activity. Nonhydrolyzable GTP analogues (GTP gamma S or GppNHp) applied via the pipette did not themselves activate Cl- conductance, but rendered Cl- current activation by brief exposures to Iso or histamine, but not to forskolin, irreversible. The Cl- conductance persistently activated by Iso was insensitive to propranolol or ACh, but could still be abolished by pipette application of PKI. The data indicate that stimulation of beta-adrenergic or histaminergic receptors in the presence of nonhydrolyzable GTP analogues causes persistent activation of Gs and uncouples it from the receptors. We conclude that autonomic regulation of cardiac Cl- conductance reflects accurately the underlying modulation of adenylyl cyclase activity and, hence, that this system is a suitable mammalian model for in situ studies of the interactions between adenylyl cyclase, Gs, Gi, and forskolin.
Compensatory signalling induced in the yolk sac vasculature by deletion of TGFβ receptors in mice

Vascular development depends on transforming growth factor β (TGFβ), but whether signalling of this protein is required for the development of endothelial cells (ECs), vascular smooth muscle cells (VSMCs) or both is unclear. To address this, we selectively deleted the type I (ALK5, TGFBR1) and type II (TβRII, TGFBR2) receptors in mice. Absence of either receptor in ECs resulted in vascular defects in the yolk sac, as seen in mice lacking receptors in all cells, causing embryonic lethality at embryonic day (E)10.5. Deletion of TβRII specifically in VSMCs also resulted in vascular defects in the yolk sac; however, these were observed at later stages of development, allowing the embryo to survive to E12.5. Because TGFβ can also signal in ECs via ALK1 (ACVRL1), we replaced ALK5 by a mutant defective in SMAD2 and SMAD3 (SMAD2/3) activation that retained the ability to transactivate ALK1. This again caused defects in the yolk sac vasculature with embryonic lethality at E10.5, demonstrating that TGFβ/ALK1 signalling in ECs cannot compensate for the lack of TGFβ/ALK5-induced SMAD2/3 signalling in vivo. Unexpectedly, SMAD2 phosphorylation and α-smooth muscle actin (SMAα, ACTA2) expression occurred in the yolk sacs of ALK5–/– embryos and ALK5–/– embryonic stem cells undergoing vasculogenesis, and these processes could be blocked by an ALK4 (ACVR1B)/ALK5 inhibitor. Together, the data show that ALK5 is required in ECs and VSMCs for yolk sac vasculogenesis; in the absence of ALK5, ALK4 mediates SMAD2 phosphorylation and consequently SMAα expression.
Molecular dynamics simulation of sodium dodecyl sulfate micelle in water: Micellar structural characteristics and counterion distribution

An all-atom 5 nanosecond molecular dynamics simulation of a water-solvated micelle containing 60 sodium dodecyl sulfate monomers was performed. Structural properties such as the radius of gyration, eccentricity, micellar size, accessible surface area, dihedral angle distribution, carbon atom distribution, and the orientation of the monomers toward the micelle center of mass were evaluated. The results indicate a stable micellar system over the duration of the simulation. Evaluation of the structure and motion of the sodium counterions show (1) a long equilibration time (1 nanosecond) is required to achieve a stable distribution of counterions and (2) approximately 25% of the sodium ions are located in the first shell and 50% are located in the first two shells of the micelle during the course of the simulation. The structure of the micelle oxygen−sodium ion radial distribution function reveals two distinct peaks which divide the counterions into those close to the micelle (first shell) those far from the .
Attention-Based Convolutional Neural Networks for Sentence Classification

Sentence classification is one of the foundational tasks in spoken language understanding (SLU) and natural language processing (NLP). In this paper we propose a novel convolutional neural network (CNN) with attention mechanism to improve the performance of sentence classification. In traditional CNN, it is not easy to encode long term contextual information and correlation between non-consecutive words effectively. In contrast, our attention-based CNN is able to capture these kinds of information for each word without any external features. We conducted experiments on various public and inhouse datasets. The experimental results demonstrate that our proposed model significantly outperforms the traditional CNN model and achieves competitive performance with the ones that exploit rich syntactic features.
Hyaluronan Expressed by the Hematopoietic Microenvironment Is Required for Bone Marrow Hematopoiesis*

Background: Hyaluronan (HA) contributes to the extracellular matrix in bone marrow. Results: HA expressed by the hematopoietic microenvironment supports hematopoiesis and is involved in hematopoietic stem/progenitor cell migration by regulating the production of soluble factors. Conclusion: Endogenous HA is an important regulatory element of the hematopoietic microenvironment. Significance: Understanding the biology of HA may help to develop strategies for improving the quality of the stem cell microenvironment. The contribution of hyaluronan (HA) to the regulatory network of the hematopoietic microenvironment was studied using knock-out mice of three hyaluronan synthase genes (Has1, Has2, and Has3). The number of hematopoietic progenitors was decreased in bone marrow and increased in extramedullary sites of Prx1-Cre;Has2flox/flox;Has1−/−;Has3−/− triple knock-out (tKO) mice as compared with wild type (WT) and Has1−/−;Has3−/− double knock-out (dKO) mice. In line with this observation, decreased hematopoietic activity was observed in long term bone marrow cultures (LTBMC) from tKO mice, whereas the formation of the adherent layer and generation of hematopoietic cells in WT and dKO cultures was not different. 4-Methylumbelliferone (4MU) was used to pharmacologically inhibit the production of HA in LTBMC. Treatment with 4MU inhibited HA synthesis, decreased expression of HAS2 and HAS3, and eliminated hematopoiesis in LTBMC, and this effect was alleviated by the addition of exogenous HA. Exogenous HA also augmented the cell motility in LTBMC, which correlated with the HA-stimulated production of chemokines and growth factors. Conditioned media from HA-induced LTBMC enhanced the chemotaxis of hematopoietic stem/progenitor cells (HSPC) in response to SDF-1. Exposure of endothelial cells to 4MU decreased their ability to support HSPC rolling and adhesion. In addition, migration of transplanted HSPC into the marrow of 4MU-pretreated mice was lower than in untreated mice. Collectively, the results suggest that HA depletion reduces the ability of the microenvironment to support HSPC, and confirm a role for HA as a necessary regulatory element in the structure of the hematopoietic microenvironment.
Regulating Systematic Occupational Health and Safety Management: Comparing the Norwegian and Australian Experience

The promotion of systematic occupational health and safety management (SOHSM) represents a comparatively recent but significant realignment of regulatory strategy that has been embraced by many, if not most, industrialized countries. As yet there has been little critical evaluation of the origins and implications of this shift, and to what extent the experience of these measures differs between countries. This article seeks to start the process of answering these questions by comparing SOHSM in Norway and Australia. We identified a number of common challenges (problems of “paper” compliance, limited union input and the growth of precarious employment). In particular, the article highlights the interdependence of OHS and industrial relations regulatory regimes and argues the move away from inclusive collectivist regimes places significant constraints on independent vetting of SOHSM - a crucial element in their effectiveness.
Differentially Methylated DNA Regions in Monozygotic Twin Pairs Discordant for Rheumatoid Arthritis: An Epigenome-Wide Study

Objectives In an explorative epigenome-wide association study (EWAS) to search for gene independent, differentially methylated DNA positions and regions (DMRs) associated with rheumatoid arthritis (RA) by studying monozygotic (MZ) twin pairs discordant for RA. Methods Genomic DNA was isolated from whole blood samples from 28 MZ twin pairs discordant for RA. DNA methylation was measured using the HumanMethylation450 BeadChips. Smoking, anti-cyclic citrullinated peptide antibodies, and immunosuppressive treatment were included as covariates. Pathway analysis was performed using GREAT. Results Smoking was significantly associated with hypomethylation of a DMR overlapping the promoter region of the RNF5 and the AGPAT1, which are implicated in inflammation and autoimmunity, whereas DMARD treatment induced hypermethylation of the same region. Additionally, the promotor region of both S100A6 and EFCAB4B were hypomethylated, and both genes have previously been associated with RA. We replicated several candidate genes identified in a previous EWAS in treatment-naïve RA singletons. Gene-set analysis indicated the involvement of immunologic signatures and cancer-related pathways in RA. Conclusion We identified several differentially methylated regions associated with RA, which may represent environmental effects or consequences of the disease and plausible biological pathways pertinent to the pathogenesis of RA.
Histamine and growth: interaction of antiestrogen binding site ligands with a novel histamine site that may be associated with calcium channels.

N,N-Diethyl-2-[(4-phenylmethyl)-phenoxy]ethanamine hydrochloride (DPPE) is a novel paradiphenylmethane derivative with antiproliferative and antiestrogenic properties. Like tamoxifen (TAM), DPPE binds to the microsomal antiestrogen binding site with high affinity (Kd approximately 50 nM), but, conversely, not to estrogen receptor or calmodulin. We now demonstrate that DPPE competes for [3H]histamine binding in rat cerebral cortex with an affinity (Ki = 4.5 +/- 2.6 X 10(-6) M) significantly greater than that of the H1 antagonist pyrilamine (Ki = 7.2 +/- 2.2 X 10(-5) M), despite the previous demonstration that pyrilamine is up to 1000 times more potent than DPPE in antagonizing histamine-induced contraction in canine tracheal smooth muscle. DPPE demonstrates antiproliferative activity against MCF-7 cells at concentrations between 1 X 10(-7) and 1 X 10(-5) M; the IC50 value of DPPE for growth inhibition at 7 days in this assay is 5 X 10(-6) M, a value equivalent to its Ki value for histamine binding. DPPE also competes for [3H]verapamil binding in membranes from whole rat brain with an affinity equal to that for verapamil (Kd = 4.0 +/- 1.8 X 10(-7) M); however, verapamil competes for [3H]DPPE binding in brain membranes and rat liver microsomes with an affinity markedly lower (Ki approximately 1 X 10(-4) M) than that of DPPE, suggesting allosteric interactions between the verapamil and DPPE sites. Unlike DPPE, verapamil is not antiproliferative in vitro against MCF-7 cells at concentrations up 1 X 10(-5) M, but, like DPPE, is cytotoxic at concentrations of 1 X 10(-4) M. In immature oophorectomized rats, verapamil or DPPE alone is antiuterotropic; however, verapamil shows no antagonism of exogenous estradiol on uterine growth, as opposed to DPPE which is a partial antagonist. Thus, the antiproliferative and antiestrogenic properties of DPPE either are not associated with calcium channel antagonism, or result from a qualitatively different effect on channels than verapamil. The in vitro antiproliferative effect of DPPE (7.5 X 10(-6) M) on MCF-7 cells at 72 h is significantly reversed by 10 mM L-histidine (70.2 +/- 12.6% reversal) and L-methionine (92.4 +/- 11.1% reversal), but not by L-ornithine, L-arginine, L-phenylalanine, or exogenous histamine. At lower concentrations of TAM (0.75 X 10(-6) M), where growth inhibition is estrogen-reversible, L-ornithine, but not L-histidine or L-methionine, causes significant reversal of growth inhibition (66.8 +/- 13.3%; p less than 0.001). (ABSTRACT TRUNCATED AT 400 WORDS)