Miracle-dz/UniFAR-FTUs huggingface dataset:
Trends in Diseases Reported on US Death Certificates That Mentioned HIV Infection, 1996-2006

Objective: We examined trends during 1996-2006 in diseases reported on death certificates that mentioned HIV infection. Methods: We analyzed multiple-cause mortality data compiled from all US death certificates with any mention of HIV to determine the annual percentages of deaths with various diseases. Results: Deaths reported with HIV during 1996-2006 decreased from 35 340 to 13 750. Standardized percentages of death certificates reporting AIDS-defining opportunistic infections also decreased: pneumocytosis (6.3% to 5.1%), nontuberculous mycobacteriosis (5.5% to 1.8%), cytomegalovirus (5.7% to 1.2%). Non-Hodgkin’s lymphoma rose from 4.8% in 1996 to 6.4% in 1997 and declined to 5.0% in 2001, while Kaposi’s sarcoma declined from 3.7% in 1996 to 1.7% in 2001; these AIDS-defining cancers had stable percentages after 2001. All other cancers increased during 1996-2006 (2.7% to 7.3%). The percentage of deaths with diseases not specifically attributable to HIV increased: liver disease (5.8% to 13.0%), kidney disease (7.9% to 12.0%), and heart disease (4.9% to 10.2%). Conclusion: Among deaths reported with HIV, the percentages reported with HIV-attributable diseases decreased, while the percentages reported with other diseases increased. Consequently, these other life-threatening diseases need more attention in the management of HIV-infected persons.
Analysis of the role of hematopoietic stem-cell transplantation in infants with acute lymphoblastic leukemia in first remission and MLL gene rearrangements: a report from the Children's Oncology Group.

PURPOSE Although the majority of children with acute lymphoblastic leukemia (ALL) are cured with current therapy, the event-free survival (EFS) of infants with ALL, particularly those with mixed lineage leukemia (MLL) gene rearrangements, is only 30% to 40%. Relapse has been the major source of treatment failure for these patients. The parallel Children's Cancer Group (CCG) 1953 and Pediatric Oncology Group (POG) 9407 studies were designed to test the hypothesis that more intensive therapy, including dose intensification of chemotherapy, and hematopoietic stem-cell transplantation (HSCT) would improve the outcome for this group of patients. PATIENTS AND METHODS One hundred eighty-nine infants (CCG 1953, n = 115; POG 9407, n = 74) were enrolled between October 1996 and August 2000. For infants with the MLL gene rearrangement and an appropriate donor, HSCT was the preferred treatment on CCG 1953 and investigator option on POG 9407 after completion of the second phase of therapy. Fifty-three infants underwent HSCT. RESULTS The 5-year EFS rate was 48.8% (95% CI, 33.9% to 63.7%) in patients who received HSCT and 48.7% (95% CI, 33.8% to 63.6%) in patients treated with chemotherapy alone (P = .60). Transplantation outcomes were not affected by the preparatory regimen or donor source. CONCLUSION Our data suggest that routine use of HSCT for infants with MLL-rearranged ALL is not indicated. However, limited by small numbers, this study should not be considered the definitive answer to this question.
Does marriage have positive effects on the psychological well-being of the individual?

Although a large number of studies show a correlation between marital status and mental health, the relative magnitude of the relationship, as compared to the strength of the relationship of other variables related to mental health, is not known. In this empirical evaluation, it is shown that in the present data, marital status is the most powerful predictor of the mental health variables considered. Data are then used to show that it is the quality of a marriage and not marriage per se that links marriage to positive mental health. The paper concludes with a discussion of some of the psychological functions of marriage.
Teachers and Teaching for the New Millennium: The Role of HBCUs

Abstract:This article presents a framework for a discussion of the role of historically Black colleges and universities (HBCUs) that focuses on teachers and teaching for the new millennium. HBCUs have the potential to make a significant difference in solving one of the most intractable problems in K-12 education: how to recruit, retain, and develop teachers for high-need schools. HBCUs are uniquely qualified to address the challenge of high-need schools. If HBCUs' colleges of education are to continue their mission of educating teachers for high-need schools, significant financial resources and other support mechanisms should be available to them. The final segment of the article contains policy recommendations.
Adaptive control for backward quadrupedal walking. I. Posture and hindlimb kinematics.

1. To gain new perspectives on the neural control of different forms of quadruped locomotion, we studied adaptations in posture and hindlimb kinematics for backward (BWD) walking in normal cats. Data from four animals were obtained from high-speed (100 fr/s) ciné film of BWD treadmill walking over a range of slow walking speeds (0.3-0.6 m/s) and forward (FWD) treadmill walking at 0.6 m/s. 2. Postural adaptations during BWD walking included flexion of the lumbar spine, compared to a relatively straight spine during FWD walking. The usual paw-contact sequence for FWD walking [right hindlimb (RH), right forelimb (RF), left hindlimb (LH), left forelimb (LF)] was typically reversed for BWD walking (RH, LF, LH, RF). The hindlimbs alternated consistently with a phase difference averaging 0.5 for both forms of walking, but the phasing of the forelimbs was variable during BWD walking. 3. As BWD walking speed increased from 0.3 to 0.6 m/s, average hindlimb cycle period decreased 21%, stance-phase duration decreased 29%, and stride length increased 38%. Compared to FWD walking at 0.6 m/s, stride length was 30% shorter, whereas cycle period and stance-phase duration were 17% shorter for BWD walking. For both directions, stance occupied 64 +/- 4% (mean +/- SD) of the step cycle. 4. During swing for both forms of walking, the hip, knee, and ankle joints had flexion (F) and extension (E1) phases; however, the F-E1 reversals occurred earlier at the hip and later at the knee for BWD than for FWD walking. At the ankle joint, the ranges of motion during the F and E1 phases were similar for both directions. During BWD walking, however, the knee flexed more and extended less, whereas the hip flexed less and extended more. Thus horizontal displacement of the limb resulted primarily from hip extension and knee flexion during BWD swing, but hip flexion and knee extension during FWD swing. 5. At the knee and ankle joints, there were yield (E2) and extension (E3) phases during stance for both forms of walking; however, yields at the knee and ankle joints were reduced during BWD walking. At the hip, angular motion was unidirectional, as the hip flexed during BWD stance but extended during FWD stance. Knee extension was the prime contributor to horizontal displacement of the body during BWD stance, but hip extension was the prime contributor to horizontal displacement during FWD stance. 6. Our kinematic data revealed two discriminators between BWD and FWD walking. (ABSTRACT TRUNCATED AT 400 WORDS)
A homolog of glyceraldehyde-3-phosphate dehydrogenase from Riemerella anatipestifer is an extracellular protein and exhibits biological activity

Riemerella anatipestifer is the causative agent of septicemia anserum exsudativa in ducks. Its pathogenesis and virulence factors are still unclear. The glycolytic enzyme, glyceraldehyde-3-phosphate dehydrogenase (GAPDH), an anchorless and multifunctional protein on the surface of several pathogenic microorganisms, is involved in virulence and adhesion. Whether homologs of GAPDH exist, and display similar characteristics in R. anatipestifer (RaGAPDH) has not been determined. In our research, the RaGAPDH activity from various R. anatipestifer isolates was confirmed. Twenty-two gapdh genes from genomic DNA of R. anatipestifer isolates were cloned and sequenced for phylogenetic analysis. The distribution of RaGAPDH in R. anatipestifer CZ2 strain was confirmed by antisera to recombinant RaGAPDH. The ability of purified RaGAPDH to bind host proteins was analyzed by solid-phase ligand-binding assay. Results revealed that all R. anatipestifer isolates showed different levels of GAPDH activity except four strains, which contained a gapdh-like gene. The gapdh of R. anatipestifer, which is located phylogenetically in the same branch as enterohemorrhagic Escherichia coli (EHEC), belonged to class I GAPDH, and encoded a 36.7-kDa protein. All RaGAPDH-encoding gene sequences from field isolates of R. anatipestifer displayed 100% homology. The RaGAPDH localized on the extracellular membrane of several R. anatipestifer strains. Further, it was released into the culture medium, and exhibited GAPDH enzyme activity. We also confirmed the binding of RaGAPDH to plasminogen and fibrinogen. These results demonstrated that GAPDH was present in R. anatipestifer, although not in all strains, and that RaGAPDH might contribute to the microorganism’s virulence.
Antiplatelet and anticoagulation therapies do not increase mortality in the absence of traumatic brain injury.

BACKGROUND : As the population continues to age, the number of patients undergoing traumatic injury while on antiplatelet or anticoagulation therapies is increasing. Mortality has been shown to increase in traumatic brain injury patients on warfarin therapy. Whether this increased mortality is seen in trauma patients without traumatic brain injury remains controversial. We investigated whether patients on antiplatelet and/or anticoagulation therapy were at increased risk of death from blunt traumatic injury in the absence of head injury. METHODS : A retrospective review of our Level I trauma center database was performed from 2002 to 2007. Inclusion criteria included all patients older than 60 years admitted to the trauma service. Only patients with a computed tomography scan negative for intracranial injury were analyzed. RESULTS : Two hundred twelve patients were found, of which 67 were found to be taking aspirin, warfarin, clopidogrel, or a combination of the three. Injury Severity Score (21 vs. 21), length of stay (11 days vs. 9 days), intensive care unit days (5 days vs. 4 days), and deaths (13% vs. 10%) were similar between those patients on antiplatelet/anticoagulation therapy and those who were not. CONCLUSION : In the absence of traumatic brain injury, the use of preinjury antiplatelet and/or anticoagulation therapy does not significantly increase the risk of mortality in the trauma patient. As the number of active seniors rises, this patient population will continue to present to the trauma service. To the best of our knowledge, this study is one of the largest addressing this question, and the only study examining the addition of antiplatelet therapy.
The effects of visual stimulation and memory on neurons of the hippocampal formation and the neighboring parahippocampal gyrus and inferior temporal cortex of the primate

The activity of 736 single neurons was recorded from the hippocampal formation (HF), the rhinal cortex (RH), the medial and anterior inferior temporal cortex (TE), or areas TF and TH of the parahippocampal gyrus (PHG) of monkeys during the performance of a delayed matching to sample task. The results indicate differences between the areas in their contributions to sensory processing and memory. Of the neurons, 55% responded to either the first (S1) and/or the second (S2) of the two successively presented visual stimuli. The proportion of responsive neurons and the proportion of neurons that responded selectively on the basis of shape or color (but not size) were significantly higher in areas TE + RH than in HF + PHG. The responses to S1 differed from those to S2 for 18% of the total sample: of these differentially responsive neurons, 66% of the TE + RH neurons responded more strongly to S1 (the sample presentation, allowing stimulus acquisition), whereas 71% of the HF + PHG neurons responded more strongly to S2 (the match/nonmatch comparison, when the behavioral decision could be made). Of 239 TE + RH neurons recorded during the delayed matching task or when objects were shown, 12% displayed evidence of memory for the previous occurrence of stimuli by responding strongly to the first, but significantly less strongly to subsequent presentations of visual stimuli that were novel or had not been seen recently. In contrast, none (0%) of 328 neurons so tested in HF and PHG had a response that declined significantly on stimulus repetition. For six (86%) of seven TE + RH neurons tested, the decrement in response persisted even after distraction by intervening presentations of other stimuli. Further evidence of information storage was found for 7 (33%) of 21 neurons for which responses to the first presentations of unfamiliar objects were significantly greater than to the first presentations of very familiar objects, even though the familiar objects had not been seen for greater than 15 min.
A Novel Quickness Improvement Method of a Magnetic-Valve Controllable Reactor

Though the magnetic-valve controllable reactor (MCR) has been actually applied in dynamic reactive compensation of electric railway and power system, its dynamic compensation performance is limited by the defect of its slow response in the transition process. Based on the structure characteristics and the magnetic flux distribution of an MCR, a novel quickness improvement method, which only needs to add auxiliary windings in two iron yokes of an MCR and several switch devices, is proposed. The mathematical model of the magnetization and demagnetization with this quickness improvement method is analyzed and built, based on which, the relationships between the estimated transition time and the parameters of the improved MCR structure are considered. Also, the simulation model of the quickness improvement method is established by MATLAB/SIMPOWERSYSTEM. The simulation results confirm correctness of the theoretical analysis and effectiveness of the novel quickness improvement method of an MCR presented here.
Attitude, associates, and recidivism: Relationship patterns among Allegheny County Jail ex-inmates

This study aims to longitudinally examine relationship patterns among attitude, criminal associates, and recidivism among Black (n = 109) and White men (n = 107) released from Allegheny County Jail in Pittsburgh, Pennsylvania. Attitude and criminal associates belong to the "big four" risk factors for recidivism (Andrews & Bonta, 1998). Review of studies reveals that different dimensions of attitude predict different measures of recidivism in different offender populations. This study examines two new attitudinal dimensions - autosuggestion and attitude toward community-based services (CBS attitude in the following). Autosuggestion measures the reported likelihood of ex-inmates' future offending. CBS attitude is a meaningful measure among jail populations given short jail stays and the critical role played by community-based services in jail ex-inmates' reintegration. The original path model with three-wave data was split into four hypotheses because of inadequate bivariate correlations among focal variables. Longitudinal relationships between attitude and recidivism, and criminal associates and recidivism, and longitudinal reciprocal relationships between attitude and criminal associates were investigated. Each hypothesis was tested in the entire sample (with interactions) and in each subgroup by race, age, and offense type. Findings indicated that criminal associates predicted recidivism and attitude, but attitude failed to predict recidivism and associates with an exception that CBS attitude predicted recidivism in some groups. This latter finding illuminates the importance of the community-based services and CBS attitudes. Autosuggestion interacted with age and CBS attitude with race in predicting recidivism. Results suggest that "very likely" response of autosuggestion may contain two different meanings - criminal intention and acknowledgement of vulnerability, possibly leading to two different recidivism results. Improvement of the two attitude measurements is suggested necessary considering the double meaning contained in autosuggestion and cultural competency of CBS attitude measure. In addition, attitude was shown to change over time, and attitude change may make a better predictor for recidivism and criminal associates than attitude measured at a time. The original path model may be tested with attitude change as a predictor. Factors for attitude change, possibly including criminal associates, should also be investigated. Other points of discussion, and significance and limitations of the study are discussed.
Nonnative Audiovisual Speech Perception in Noise: Dissociable Effects of the Speaker and Listener

Nonnative speech poses a challenge to speech perception, especially in challenging listening environments. Audiovisual (AV) cues are known to improve native speech perception in noise. The extent to which AV cues benefit nonnative speech perception in noise, however, is much less well-understood. Here, we examined native American English-speaking and native Korean-speaking listeners' perception of English sentences produced by a native American English speaker and a native Korean speaker across a range of signal-to-noise ratios (SNRs;−4 to −20 dB) in audio-only and audiovisual conditions. We employed psychometric function analyses to characterize the pattern of AV benefit across SNRs. For native English speech, the largest AV benefit occurred at intermediate SNR (i.e. −12 dB); but for nonnative English speech, the largest AV benefit occurred at a higher SNR (−4 dB). The psychometric function analyses demonstrated that the AV benefit patterns were different between native and nonnative English speech. The nativeness of the listener exerted negligible effects on the AV benefit across SNRs. However, the nonnative listeners' ability to gain AV benefit in native English speech was related to their proficiency in English. These findings suggest that the native language background of both the speaker and listener clearly modulate the optimal use of AV cues in speech recognition.
Epidemiological studies on patients with a persistent vegetative state

Persistent vegetative state after severe brain damage was studied epidemiologically in 110 cases from 1973 to 1976. The causes of brain damage were varied. More than one-third of the cases were due to trauma, and about one-fifth were the result of vascular accidents. Three year observation revealed that 65% of the patients died during this period. Mean survival time for dead patients was 38 months. Reactivity, clinical signs, EEG findings, methods of management, and results of various trials of treatment were investigated in connection with the patient's prognosis.
Equilibrium Distribution of Agents by Types in a Market, and Existence of Power Laws (Special Issue on Stochastic and Statistical Analysis in Mathematical Finance)

This paper considers a market in which shares of a single asset is traded by agents with many strategies. The market behavior is examined by regarding clusters of agents with same trading rules as random combinatorial partitions of agents by types. The equilibrium distribution is shown to be the Ewens sampling formula. When agents are positively correlated, it is shown that a small number of groupings such as two types of agents dominate the markets. Distributions for large price difference or return are shown to be power-laws if a certain set of conditions is satisfied.
Las consecuencias del divorcio en los hijos

espanolLos hijos de padres separados o divorciados, como grupo, presentan mas problemas de conducta y personales que los que viven en hogares intactos. Sin embargo, las estadisticas ocultan el hecho de que existe una gran variabilidad en la forma en que los ninos y los adolescentes responden a la ruptura matrimonial de sus progenitores. La investigacion actual ha abandonado el modelo patogenico para adoptar unos modelos basados en factores de riesgo y de resistencia que pretenden identificar las variables del nino, de los procesos familiares y del contexto ecologico que permitan explicar la relacion entre separacion /divorcio y problemas de adaptacion de los hijos. En este trabajo presentamos una revision de los estudios que han investigado los principales factores de riesgo y de resistencia relacionados con los problemas de adaptacion en los hogares monoparentales. EnglishAs a group, children of divorced parents present more personal and behaviour problems than those who live in intact family environments. However, statistics mask the fact that children and adolescents respond in many different ways to the break-up of their parents’ marriage. In examining relation between divorce and children’s adjustment problems, current research has given up the pathogenic model in favour of models based on risk and resistance factors in an attempt to identify child variables and those of family processes and of the ecological context. This study presents a review of the research of the main risk and resistance factors related to child and adolescent adjustment problems in single-parent homes.
Transformation of cardiac endothelium into cushion mesenchyme is dependent on ES/130: temporal, spatial, and functional studies in the early chick embryo.

ES/130 is a novel 130-kDa protein that has been linked previously to the transformation of endocardial endothelium into cushion mesenchyme. In the present study we report the localization of protein and mRNA for ES/130 in stages 7-plus through 20 chick embryos and present functional data related to a potential mechanism for ES/130. The temporal and spatial regulation of ES/130 expression suggests that this epithelial-to-mesenchymal transformation is a result of homogenetic induction. Functional studies indicate that myocardially derived ES/130 elicits expression of this protein by target AV endothelial cells, which is linked to a signal transduction cascade. The localization of ES/130 to other sites of inductive interactions (e.g., limb bud ectoderm, gut, and notochord) implies that this protein may have a more widespread importance to embryogenesis beyond its involvement in cardiac cushion tissue formation.