Miracle-dz/UniFAR-FTUs huggingface dataset:
Dynamics of n-alkanes: Comparison to Rouse model

The crossover to Rouse-type behavior for the self-diffusion constant D, the viscosity η, and the equilibrium structural statistics of n-alkanes (6⩽n⩽66) is studied numerically. For small n the chains are non-Gaussian and the mean squared end-to-end distance 〈R2〉 is greater than 6〈RG2〉, where 〈RG2〉 is the mean squared radius of gyration. As n increases, 〈R2〉/〈RG2〉→6(1+a/n), where a depends on the interaction model. At constant density, the Rouse model is used to extract the monomeric friction coefficient ζ and the viscosity η independently from the diffusion constant D and the longest relaxation time τR. ζD extracted from D is nearly independent of chain length while ζτ obtained from τR is much larger than ζD for small n. The viscosity measured in a nonequilibrium molecular dynamics simulation is closely approximated by the value of η determined from τR while η inferred from D is smaller for small n. For n≳60, the two estimates for both ζ and η agree as predicted from the Rouse model. D calculated from thr.
Awareness of, responsiveness to and practice of patients’ rights at Uganda's national referral hospital

Abstract Background The realisation of patients’ rights in resource-constrained and patient-burdened public health care settings in Uganda remains an obstacle towards quality health care delivery, health care-seeking behaviour and health outcomes. Although the Uganda Patients’ Charter of 2009 empowers patients to demand quality care, inequitable access and abuse remain common. Aim The study aimed to assess level of awareness of, responsiveness to and practice of patients’ rights amongst patients and health workers (HWs) at Uganda's national referral hospital, Mulago Hospital in Kampala. Methods A three-phase cross-sectional questionnaire-based descriptive survey was conducted amongst 211 patients, 98 HWs and 16 key informants using qualitative and quantitative data collection methods. The study was conducted in May–June 2012, 2.5 years after the launch of the Uganda Patients’ Charter. Results At least 36.5% of patients faced a challenge regarding their rights whilst seeking health care. Most of the patients (79%) who met a challenge never attempted to demand their rights. Most patients (81.5%) and HWs (69.4%) had never heard of the Uganda Patients’ Charter. Awareness of patients’ rights was significantly higher amongst HWs (70%) than patients (40%) (p < 0.01). Patients’ awareness was associated with education level (χ2 = 42.4, p < 0.001), employment status (χ2 = 33.6, p < 0.001) and hospital visits (χ2 = 3.9, p = 0.048). For HWs it was associated with education level (χ2 = 155.6, p < 0.001) and length of service (χ2 = 154.5, p <0.001). Patients feel powerless to negotiate for their rights and fear being discriminated against based on their ability to bribe HWs with money to access care, and political, socio-economic and tribal status. Conclusion and recommendations Awareness of, responsiveness to and practice of patients’ rights remains limited at Mulago Hospital. There is a need for urgent implementation of an integrated multilevel, multichannel, patient-centred approach that incorporates social services and addresses intrinsic patient, HW and health system factors to strengthen patients’ rights issues at the hospital.
Limit Laws for Sums of Functions of Subtrees of Random Binary Search Trees

We consider sums of functions of subtrees of a random binary search tree and obtain general laws of large numbers and central limit theorems. These sums correspond to random recurrences of the quicksort type, $X_n {\stackrel{\cal L}{=}} X_{I_n} + X'_{n-1-I_n} + Y_n$, $n \ge 1$, where In is uniformly distributed on {0,1,. , n-1 }, Yn is a given random variable, $X_k {\stackrel{\cal L}{=}} X'_k$ for all k, and, given In, XIn and X'n-1-In are independent. Conditions are derived such that $(X_n - \mu n )/\sigma \sqrt{n} {\stackrel{\cal L}{\rightarrow}} {\cal N}(0,1)$, the normal distribution, for some finite constants $\mu$ and $\sigma$.
Effect of microgravity on the expression of mitochondrial enzymes in rat cardiac and skeletal muscles.

The purpose of this study was to examine the expression of nuclear and mitochondrial genes in cardiac and skeletal muscle (triceps brachii) in response to short-duration microgravity exposure. Six adult male rats were exposed to microgravity for 6 days and were compared with six ground-based control animals. We observed a significant 32% increase in heart malate dehydrogenase (MDH) enzyme activity, which was accompanied by a 62% elevation in heart MDH mRNA levels after microgravity exposure. Despite modest elevations in the mRNAs encoding subunits III, IV, and VIc as well as a 2.2-fold higher subunit IV protein content after exposure to microgravity, heart cytochrome c oxidase (CytOx) enzyme activity remained unchanged. In skeletal muscle, MDH expression was unaffected by microgravity, but CytOx activity was significantly reduced 41% by microgravity, whereas subunit III, IV, and VIc mRNA levels and subunit IV protein levels were unaltered. Thus tissue-specific (i.e., heart vs. skeletal muscle) differences exist in the regulation of nuclear-encoded mitochondrial proteins in response to microgravity. In addition, the expression of nuclear-encoded proteins such as CytOx subunit IV and expression of MDH are differentially regulated within a tissue. Our data also illustrate that the heart undergoes previously unidentified mitochondrial adaptations in response to short-term microgravity conditions more dramatic than those evident in skeletal muscle. Further studies evaluating the functional consequences of these adaptations in the heart, as well as those designed to measure protein turnover, are warranted in response to microgravity.
Hydrological cycle and water balance estimates for the megadune–lake region of the Badain Jaran Desert, China

The hydrology and water balance of megadunes and lakes have been investigated in the Badain Jaran Desert of China. Field observations and analyses of sand layer water content, field capacity, secondary salt content, and grain size reveal 3 types of important natural phenomenon: (a) vegetation bands on the leeward slope of the megadunes reflect the hydrological regime within the sandy vadose zone; (b) seepage, wet sand deposits, and secondary salt deposits indicate the pattern of water movement within the sandy vadose zone; (c) zones of groundwater seeps and descending springs around the lakes reflect the influence of the local topography on the hydrological regime of the megadunes. The seepage exposed on the sloping surface of the megadunes and gravity water contained within the sand layer confirm the occurrence of preferential flow within the vadose zone of the megadunes. Alternating layers of coarse and fine sand create the conditions for the formation of preferential flows. The preferential flows promote movement of water within the sand layer water that leads to deep penetration of water within the megadunes and ultimately to the recharging of groundwater and lake water. Our results indicate that a positive water balance promotes recharge of the megadunes, which depends on the high permeability of the megadune material, the shallow depth of the surface sand layer affected by evaporation, the occurrence of rainfall events exceeding 15 mm, and the sparse vegetation cover. Water balance estimates indicate that the annual water storage of the megadunes is about 7.5 mm, accounting for only 8% of annual precipitation; however, the shallow groundwater per unit area under the megadunes receives only 3.6% of annual precipitation, but it is still able to maintain a dynamic balance of the lake water. From a water budget perspective, the annual water storage in the megadunes is sufficient to serve as a recharge source for lake water, thereby enabling the long‐term persistence of the lakes. Overall, our findings demonstrate that precipitation is a significant component of the hydrological cycle in arid deserts.
Petri net supervisors for DES with uncontrollable and unobservable transitions

A supervisor synthesis technique for Petri net plants with uncontrollable and unobservable transitions, that enforces the conjunction of a set of linear inequalities on the reachable markings of the plant, is presented. The approach is based on the concept of Petri net place invariants. Each step of the procedure is illustrated through a running example involving the supervision of a robotic assembly cell. The controller is described by an auxiliary Petri net connected to the plant's transitions, providing a unified Petri net model of the closed-loop system. The synthesis technique is based on the concept of admissible constraints. Procedures are given for identifying all admissible linear constraints for a plant with uncontrollable and unobservable transitions, as well as methods for transforming inadmissible constraints into admissible ones. A technique is described for creating a modified Petri net controller that enforces the union of all of these control laws. The method is practical and computationally inexpensive in terms of size, design time, and implementation complexity.
Occupational Determinants of Methicillin-Resistant Staphylococcus aureus Colonization Among Healthcare Workers: A Longitudinal Study in a Rehabilitation Center

BACKGROUND Staphylococcus aureus carriage among healthcare workers (HCWs) is a concern in hospital settings, where it may provide a reservoir for later infections in both patients and staff. Earlier studies have shown that the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) carriage in HCWs is highly variable, depending notably on location, hospital department type, MRSA prevalence among patients, and type of contacts with patients. However, MRSA incidence in HCWs and its occupational determinants have seldom been studied. METHODS A prospective, observational cohort study was conducted between May and October 2009 in a French rehabilitation center hospital. HCWs and patients were screened weekly for S. aureus nasal carriage. Methicillin-susceptible S. aureus and MRSA prevalence and incidence were estimated and factors associated with MRSA acquisition were identified using generalized estimating equation regression methods. RESULTS Among 343 HCWs included in the analysis, the average prevalence was 27% (95% CI, 24%–29%) for methicillin-susceptible S. aureus and 10% (8%–11%) for MRSA. We observed 129 MRSA colonization events. According to the multivariable analysis, high MRSA prevalence level among patients and HCW occupation were significantly associated with MRSA acquisition in HCWs, with assistant nurses being more at risk than nurses (odds ratio, 2.2; 95% CI, 1.4–3.6). CONCLUSIONS Our findings may help further our understanding of the transmission dynamics of MRSA carriage acquisition in HCWs, suggesting that it is notably driven by carriage among patients and by the type of contact with patients. Infect Control Hosp Epidemiol 2015;36(7):767–776
Genetic analysis of skin wound healing and scarring in a porcine model

Contraction is a normal part of skin wound healing and wound closure; however, excessive contraction and severe scarring concern patients and physicians alike. The present study has investigated the degree and kinetics of wound contraction in a porcine model of wound healing, to elucidate the genetic and molecular basis for abnormal skin wound healing and scarring. Healing of excisional skin wounds in juvenile female Yorkshire pigs closely resembled normal healing in humans. In contrast, identical wounds in female red Duroc pigs contracted significantly more, forming hypercontracted, hyperpigmented scars. Yorkshire × red Duroc F1 animals healed without hyperpigmentation, but with significantly greater wound contraction than observed in either parent breed. To examine the genetic transmission of the hypercontractile phenotype, all F1 animals were bred to a single Yorkshire boar, generating 20 backcross animals. All backcross animals healed with significantly less contraction than the normal Yorkshire animals. These findings suggest that the genetic contribution to scar phenotype in this animal model is complex, with a limited number of major genes controlling wound contraction, and an unknown number of minor genes that appear to modulate the impact of the major genes.
Rotavirus vaccine strain transmission by vaccinated infants in the foster home

Previous studies have demonstrated the transmission of rotavirus vaccine strains from vaccinated children to nonvaccinated siblings. We sought to fully elucidate the safety of rotavirus (RV) vaccination in closed contact circumstance, such as the foster home for future assessment of the vaccine safety in an neonatal intensive care unit. Stool samples were collected from 4 RV vaccinated (160 samples) and 23 unvaccinated (766 samples) infants. RV viral RNA loads were measured using real‐time reverse transcription polymerase chain reaction (RT‐PCR). RV vaccine strain RNA was persistently detected in stool samples collected from the four vaccine recipients and one unvaccinated infant, but not in the stool samples collected from the 22 other unvaccinated infants. The unvaccinated infant who tested positive for the RV vaccine strain was vaccinated prior to enrollment in this study. The quantitative real‐time RT‐PCR data revealed a peak viral RNA load 1 week after vaccination followed by a gradual decrease. The current study suggests that RV vaccination may be safe in a close contact environment because there was limited transmission from RV vaccinated to unvaccinated infants. J. Med. Virol. 89:79–84, 2017. © 2016 Wiley Periodicals, Inc.
Hepatoprotective Effect of Silymarin (Silybum marianum) on Hepatotoxicity Induced by Acetaminophen in Spontaneously Hypertensive Rats

This study was aimed to investigate the effect of Silymarin (SLM) on the hypertension state and the liver function changes induced by acetaminophen (APAP) in spontaneously hypertensive rat (SHR). Animals normotensive (N) or hypertensive (SHR) were treated or not with APAP (3 g/kg, oral) or previously treated with SLM. Twelve hours after APAP administration, plasmatic levels of liver function markers: alanine aminotransferase (ALT), aspartate aminotransferase (AST), glucose (GLU), gamma glutamyl transferase (γ-GT), and alkaline phosphatase (ALP) of all groups, were determined. Liver injury was assessed using histological studies. Samples of their livers were then used to determine the myeloperoxidase (MPO) activity and nitric oxide (NO) production and were also sectioned for histological analysis. No differences were observed for ALT, γ-GT, and GLU levels between SHR and normotensive rats groups. However, AST and ALP levels were increased in hypertensive animals. APAP treatment promoted an increase in ALT and AST in both SHR and N. However, only for SHR, γ-GT levels were increased. The inflammatory response evaluated by MPO activity and NO production showed that SHR was more susceptible to APAP effect, by increasing leucocyte infiltration. Silymarin treatment (Legalon) restored the hepatocyte functional and histopathological alterations induced by APAP in normotensive and hypertensive animals.
Endogenous Levels of Circulating Androgens and Risk of Crohn's Disease and Ulcerative Colitis Among Women: A Nested Case–Control Study from the Nurses' Health Study Cohorts

Background:Androgens, which are known to be altered by exogenous hormone use, have recently been linked to alterations of the gut microbiome and mucosal immune function. No study has evaluated the association between circulating levels of androgens and risk of Crohn's disease (CD) and ulcerative colitis (UC). Methods:We conducted a nested case–control study of women enrolled in the Nurses' Health Study and Nurses' Health Study II who provided a blood specimen. Cases of CD and UC were each matched to 2 controls. Prediagnosis plasma levels of dehydroepiandrosterone sulfate, testosterone, and sex hormone–binding globulin were measured. We examined the association of each analyte with risk of CD or UC using conditional logistic regression models. Results:Compared with women in the lowest quintile of testosterone, the multivariable-adjusted odds ratios for CD were 0.86 (95% confidence interval, 0.39–1.90) for women in the second quintile, 0.49 (95% confidence interval, 0.21–1.15) for the third quartile, 0.22 (0.08–0.65) for the fourth quintile, and 0.39 (95% confidence interval, 0.16–0.99) for the highest quintile (Plinear trend = 0.004). In contrast, we did not observe a consistent association between prediagnostic testosterone and risk of UC (Plinear trend = 0.84). We also did not observe any association between plasma levels of sex hormone–binding globulin or dehydroepiandrosterone sulfate and risk of UC or CD (all Plinear trends > 0.10). Conclusions:Among women, prediagnostic circulating testosterone is associated with a lower risk of CD but not UC. Further studies to understand the biological mechanisms by which endogenous androgens may mediate the etiopathogenesis of CD are warranted.
Hierarchical Phrase-Based Translation with Suffix Arrays

A major engineering challenge in statistical machine translation systems is the efficient representation of extremely large translation rulesets. In phrase-based models, this problem can be addressed by storing the training data in memory and using a suffix array as an efficient index to quickly lookup and extract rules on the fly. Hierarchical phrasebased translation introduces the added wrinkle of source phrases with gaps. Lookup algorithms used for contiguous phrases no longer apply and the best approximate pattern matching algorithms are much too slow, taking several minutes per sentence. We describe new lookup algorithms for hierarchical phrase-based translation that reduce the empirical computation time by nearly two orders of magnitude, making on-the-fly lookup feasible for source phrases with gaps.
Ant Routing in Mobile Ad Hoc Networks

We study the performance of ant routing for static and dynamic network topologies. We also compare the performance of ant routing with AODV and DSR for ad hoc networks. The simulations show that the ant routing algorithm performs well for static topologies. However, the routing overhead in ant routing is more than AODV and DSR. Therefore, ant routing performs worse than AODV and DSR in ad hoc networks because of the limited capacity and restrictions on the buffer size. Moreover, with mobility, a large number of data packets in ant routing experience loops that degrade the end-to-end performance.
Spatio-temporal Co-Occurrence Characterizations for Human Action Classification

The human action classification task is a widely researched topic and is still an open problem. Many state-of-the-arts approaches involve the usage of bag-of-video-words with spatio-temporal local features to construct characterizations for human actions. In order to improve beyond this standard approach, we investigate the usage of co-occurrences between local features. We propose the usage of co-occurrences information to characterize human actions. A trade-off factor is used to define an optimal trade-off between vocabulary size and classification rate. Next, a spatio-temporal co-occurrence technique is applied to extract co-occurrence information between labeled local features. Novel characterizations for human actions are then constructed. These include a vector quantized correlogram-elements vector, a highly discriminative PCA (Principal Components Analysis) co-occurrence vector and a Haralick texture vector. Multi-channel kernel SVM (support vector machine) is utilized for classification. For evaluation, the well known KTH as well as the challenging UCF-Sports action datasets are used. We obtained state-of-the-arts classification performance. We also demonstrated that we are able to fully utilize co-occurrence information, and improve the standard bag-of-video-words approach.
Novel Antiangiogenic Therapies in Ovarian Cancer

Epithelial ovarian cancer is the leading cause of death in the developed world for women with gynecologic carcinomas. Despite the effectiveness of platinum salts and taxanes as primary treatments, approximately 80% of women will recur and for them prognosis with available treatments is poor. Of the novel mechanisms under active investigation, there is ample evidence to indicate that angiogenesis is important to the development, progression and poor prognosis of ovarian cancer. Novel treatments are therefore required. A number of agents are undergoing evaluation, including vascular disrupting agents, angiogenesis inhibitors, tyrosine kinase inhibitors and agents targeting the folate receptor. At present, Phase III data are only available for the VEGF-targeted monoclonal antibody, bevacizumab, and that has demonstrated a progression-free survival benefit when used in combination with first-line paclitaxel/carboplatin and continued as maintenance therapy. The strategy of inhibiting angiogenesis in ovarian cancer remains promising. However, other agents in development may point to other important targets in ovarian cancer.
Algorithm Selection for Constraint Optimization Domains

In this paper we investigate methods for selecting the best algorithms in classic distributed constraint optimization problems. While these are NP-complete problems, many heuris- tics have nonetheless been proposed. We found that the best method to use can change radically based on the specifics of a given problem instance. Thus, dynamic methods are needed that can choose the best approach for a given problem. We found that large differences typically exist in the expected utility between algorithms, allowing for a clear policy. We present a dynamic algorithm selection approach based on this realization. As support for this approach, we describe the results from thousands of trials from Distributed Constraint Optimization problems that demonstrates the strong statistical improvement of this dynamic approach over the static methods they are based on. I. INTRODUCTION In this paper we claim that an algorithm selection approach is helpful in dictating which type of ap- proach to use. The key to this approach is that differ- ences between algorithms are typically quite large, and can be locally measured. This allows agents to locally control what information to transfer to group members. To demonstrate the effectiveness of this approach we study a general Distributed Constraint Optimization Problem (DCOP) domain (10), (11), (21). We performed thousands of trials involving a variety team sizes and problem parameters and found that the described algorithm selection ap- proach was effective in significantly outperforming the static methods they were based on.