Miracle-dz/UniFAR-FTUs huggingface dataset:
Increased risk of posterior circulation infarcts among ischemic stroke patients with cervical spondylosis

Background Cervical spondylosis is one of the extrinsic factors causing vertebral artery stenosis. Several case studies have reported compression of the vertebral artery induced by cervical osteophytes that has resulted in posterior circulation infarcts (POCI). However, to the best of our knowledge, no studies have yet analyzed differences in the risk factors and stroke subtypes between ischemic stroke patients with cervical spondylosis and those without. Purpose In the case-controlled study reported here, we analyzed the risk factors and stroke subtypes in ischemic stroke patients with and without cervical spondylosis. Characteristics in all the recruited patients with POCI and non-POCI were further compared to extract other risk factors that could predict the occurrence of POCI. Methods and patients We filtered out ischemic stroke patients with cervical spondylosis (“Stroke+C” group) by International Classification of Diseases, Ninth Revision codes. We analyzed the data of 38 subjects in the Stroke+C group and 152 sex- and age-comparable ischemic stroke patients without cervical spondylosis (“Stroke−C” group). We recorded the demographic characteristics including sex and age, and stroke risk factors, including diabetes mellitus, hypertension, heart disease, hyperlipidemia, and smoking habits. The stroke classifications were defined by the Oxford Community Stroke Project classification. All subjects were further categorized into POCI or non-POCI groups. The ultrasound findings of the vertebral arteries (extracranial and intracranial) in the Stroke+C group were also recorded. Results More patients in the Stroke+C group tended to have POCI (34.2%) than patients in the Stroke−C group (17.5%) (odds ratio [OR] =2.41, P<0.05). Furthermore, hypertension (OR=3.41, P<0.01) and cervical spondylosis (OR=2.41, P<0.05) were two independent risk factors for POCI in ischemic stroke patients. Conclusion Ischemic stroke patients with cervical spondylosis are more prone to POCI than those without cervical spondylosis. Hypertension is another identified risk factor for POCI in ischemic stroke patients. The occurrence of POCI should be highlighted for patients with cervical spondylosis.
System Synthesis of Synchronous Multimedia Applications

Modern system design is being increasingly driven by applications such as multimedia and wireless sensing and communications, which all have intrinsic quality of service (QoS) requirements, such as throughput, error-rate, and resolution. One of the most crucial QoS guarantees that the system has to provide is the timing constraints among the interacting media (synchronization) and within each media (latency). We have developed the first framework for systems design with timing QoS guarantees, latency and synchronization. In particular, we address how to design system-on-chip with minimal silicon area to meet timing constraints. We propose the two-phase design methodology. In the first phase, we select an architecture which facilitates the needs of synchronous low latency applications well. In the second phase, for a given processor configuration, we use our new scheduler in such a way that storage requirements are minimized. We have develop scheduling algorithms that solve the problem optimally for a-priori specified applications. The algorithms have been implemented and their effectiveness demonstrated on a set of simulated MPEG streams from popular movies.
Can the UNAIDS modes of transmission model be improved?: a comparison of the original and revised model projections using data from a setting in west Africa

Objective:The UNAIDS modes of transmission model (MoT) is a user-friendly model, developed to predict the distribution of new HIV infections among different subgroups. The model has been used in 29 countries to guide interventions. However, there is the risk that the simplifications inherent in the MoT produce misleading findings. Using input data from Nigeria, we compare projections from the MoT with those from a revised model that incorporates additional heterogeneity. Methods:We revised the MoT to explicitly incorporate brothel and street-based sex-work, transactional sex, and HIV-discordant couples. Both models were parameterized using behavioural and epidemiological data from Cross River State, Nigeria. Model projections were compared, and the robustness of the revised model projections to different model assumptions, was investigated. Results:The original MoT predicts 21% of new infections occur in most-at-risk-populations (MARPs), compared with 45% (40–75%, 95% Crl) once additional heterogeneity and updated parameterization is incorporated. Discordant couples, a subgroup previously not explicitly modelled, are predicted to contribute a third of new HIV infections. In addition, the new findings suggest that women engaging in transactional sex may be an important but previously less recognized risk group, with 16% of infections occurring in this subgroup. Conclusion:The MoT is an accessible model that can inform intervention priorities. However, the current model may be potentially misleading, with our comparisons in Nigeria suggesting that the model lacks resolution, making it challenging for the user to correctly interpret the nature of the epidemic. Our findings highlight the need for a formal review of the MoT.
Silicone hydrogel contact lens surface analysis by atomic force microscopy: shape parameters

Purpose: Average roughness (Ra) is generally used to quantify roughness; however it makes no distinction between spikes and troughs. Shape parameters as kurtosis (Rku) and skewness (Rsk) serve to distinguish between two profiles with the same Ra. They have been reported in many biomedical fields, but they were no applied to contact lenses before. The aim of this study is to analyze surface properties of four silicone hydrogel contact lenses (CL) by Atomic Force Microscopy (AFM) evaluating Ra, Rku and Rsk. Methods: CL used in this study were disposable silicone hydrogel senofilcon A, comfilcon A, balafilcon A and lotrafilcon B. Unworn CL surfaces roughness and topography were measured by AFM (Veeco, multimode-nanoscope V) in tapping modeTM. Ra, Rku and Rsk for 25 and 196 μm2 areas were determined. Results: Surface topography and parameters showed different characteristics depending on the own nature of the contact lens (Ra/Rku/Rsk for 25 and 196 μm2 areas were: senofilcon A 3,33/3,74/0,74 and 3,76/18,16/1,75; comfilcon A: 1,56/31,09/2,93 and 2,76/45,82/3,60; balafilcon A: 2,01/33,62/-2,14 and 2,54/23,36/-1,96; lotrafilcon B: 26,97/4,11/-0,34 and 29,25/2,82/-0,23). In lotrafilcon B, with the highest Ra, Rku showed a lower degree of peakedness of its distribution. Negative Rsk value obtained for balafilcon A showed a clear predominance of valleys in this lens. Conclusions: Kku and Rsk are two statistical parameters useful to analyse CL surfaces, which complete information from Ra. Differences in values distribution and symmetry were observed between CL.
COSMOS: Three-dimensional Weak Lensing and the Growth of Structure

We present a three-dimensional cosmic shear analysis of the Hubble Space Telescope COSMOS survey, the largest ever optical imaging program performed in space. We have measured the shapes of galaxies for the telltale distortions caused by weak gravitational lensing and traced the growth of that signal as a function of redshift. Using both 2D and 3D analyses, we measure cosmological parameters Ωm, the density of matter in the universe, and σ8, the normalization of the matter power spectrum. The introduction of redshift information tightens the constraints by a factor of 3 and also reduces the relative sampling (or "cosmic") variance compared to recent surveys that may be larger but are only two-dimensional. From the 3D analysis, we find that σ8(Ωm/0.3)0.44 = 0.866 at 68% confidence limits, including both statistical and potential systematic sources of error in the total budget. Indeed, the absolute calibration of shear measurement methods is now the dominant source of uncertainty. Assuming instead a baseline cosmology to fix the geometry of the universe, we have measured the growth of structure on both linear and nonlinear physical scales. Our results thus demonstrate a proof of concept for tomographic analysis techniques that have been proposed for future weak-lensing surveys by a dedicated wide-field telescope in space.
Web-Delivered Cognitive Behavioral Therapy for Distressed Cancer Patients: Randomized Controlled Trial

Background Web-based interventions present a potentially cost-effective approach to supporting self-management for cancer patients; however, further evidence for acceptability and effectiveness is needed. Objective The goal of our research was to assess the effectiveness of an individualized Web-based cognitive behavioral therapy (CBT) intervention on improving psychological and quality of life outcomes in cancer patients with elevated psychological distress. Methods A total of 163 distressed cancer patients (111 female, 68.1%) were recruited through the Queensland Cancer Registry and the Cancer Council Queensland Cancer Helpline and randomly assigned to either a Web-based tailored CBT intervention (CancerCope) (79/163) or a static patient education website (84/163). At baseline and 8-week follow-up we assessed primary outcomes of psychological and cancer-specific distress and unmet psychological supportive care needs and secondary outcomes of positive adjustment and quality of life. Results Intention-to-treat analyses showed no evidence of a statistically significant intervention effect on primary or secondary outcomes. However, per-protocol analyses found a greater decrease for the CancerCope group in psychological distress (P=.04), cancer-specific distress (P=.02), and unmet psychological care needs (P=.03) from baseline to 8 weeks compared with the patient education group. Younger patients were more likely to complete the CancerCope intervention. Conclusions This online CBT intervention was associated with greater decreases in distress for those patients who more closely adhered to the program. Given the low costs and high accessibility of this intervention approach, even if only effective for subgroups of patients, the potential impact may be substantial. Trial Registration Australian New Zealand Clinical Trials Registry ACTRN12613001026718; https://www.anzctr. org.au/Trial/Registration/TrialReview.aspx? id=364768&isReview=true (Archived by WebCite at http://www.webcitation.org/6uPvpcovl)
Proton- and Gamma-Induced Effects on Erbium-Doped Optical Fibers

We characterized the responses of three erbium-doped fibers with slightly different concentrations of rare-earth ions (240-290 ppm) and Al2O3 (7-10 wt.%) during proton and gamma-ray exposures. We have simultaneously measured the radiation-induced attenuation (RIA) around the Er3+ ion pumping wavelength (980 nm) and the associated changes of the Er3+ emission around 1530 nm. The three erbium-doped fibers show similar radiation responses. All fibers exhibit RIA levels between 9 times 10-3 and 1.7 times 10-2 dB m-1 Gy-1 at 980 nm and between 4 times 10-3 and 1.1 times 10-2 dB m-1 Gy-1 at 1530 nm. Protons and gamma-rays lead to similar radiation damages, with small differences between the protons of different energies (50 MeV and 105 MeV). Furthermore, we have performed online measurements of the spectral dependence of RIA from 600 to 1600 nm and offline measurements from 1200 to 2400 nm. The three fibers exhibit the same spectral response. Losses decrease monotonically from the visible to the infrared part of the spectrum. We have performed spectral decomposition of these RIA curves with the help of absorption bands previously associated with radiation-induced point defects. Our analysis shows that the main part of the RIA (600-1700 nm) in erbium-doped glass can be explained by the generation of Al-related point defects. The other defects related to the germanium and phosphorus doping of the silica seem to have a lower contribution to the induced losses. The Er3+ ion properties seem to be mainly unaffected by proton exposure, suggesting a solvation shell around the Er3+ ion formed by Al2O3 species.
FPGA implementation of joint CFO and IQ-imbalance compensator for narrow-band wireless system

In direct conversion receiver, I/Q imbalance is caused by non orthogonality between in-phase component and quadrature-phase component caused by imperfections of quadrature demodulator. In addition, carrier frequency offset (CFO) occurs as well. In this paper, we present a register transfer level (RTL) design of joint CFO and I/Q imbalance compensator. First, we verify the efficiency of compensation algorithm with computer simulation, and then we show a bit error rate (BER) characteristic. After that, we made an RTL design to compensate CFO and I/Q imbalance.We also measure the efficiency of system in this step by looking at constellation of received signal. Finally, we implement the RTL design of compensation system in a field programmable gate array (FPGA). We show the effect of compensation system by simulation on RTL and verification on FPGA.
Perception as a closed-loop convergence process

Perception of external objects involves sensory acquisition via the relevant sensory organs. A widely-accepted assumption is that the sensory organ is the first station in a serial chain of processing circuits leading to an internal circuit in which a percept emerges. This open-loop scheme, in which the interaction between the sensory organ and the environment is not affected by its concurrent downstream neuronal processing, is strongly challenged by behavioral and anatomical data. We present here a hypothesis in which the perception of external objects is a closed-loop dynamical process encompassing loops that integrate the organism and its environment and converging towards organism-environment steady-states. We discuss the consistency of closed-loop perception (CLP) with empirical data and show that it can be synthesized in a robotic setup. Testable predictions are proposed for empirical distinction between open and closed loop schemes of perception. DOI: http://dx.doi. org/10.7554/eLife.12830. 001
Carotid Artery Diameter in Men and Women and the Relation to Body and Neck Size

Background and Purpose— To explore relationships among gender, body size, neck size, and the diameters of the common carotid artery (CCA) and internal carotid artery (ICA). Methods— Using multivariate regression, the best predictors of sonographic diameters of CCA and ICA were determined based on age, height, weight, body mass index, body surface area, neck circumference, neck length, and blood pressure. Results— Measurements were obtained in 500 consecutive patients (age 52±15 years; 61% women). Mean diameters of ICA (4.66±0.78 mm) and CCA (6.10±0.80 mm) in women were significantly smaller than in men: 5.11±0.87 mm and 6.52±0.98 mm, respectively. Sex significantly influenced the diameters after controlling for body size, neck size, age, and blood pressure. Conclusions— Carotid arteries are smaller in women even after adjusting for body and neck size, age, and blood pressure.
Native Bacterial Endophytes Promote Host Growth in a Species-Specific Manner; Phytohormone Manipulations Do Not Result in Common Growth Responses

Background All plants in nature harbor a diverse community of endophytic bacteria which can positively affect host plant growth. Changes in plant growth frequently reflect alterations in phytohormone homoeostasis by plant-growth-promoting (PGP) rhizobacteria which can decrease ethylene (ET) levels enzymatically by 1-aminocyclopropane-1-carboxylate (ACC) deaminase or produce indole acetic acid (IAA). Whether these common PGP mechanisms work similarly for different plant species has not been rigorously tested. Methodology/ Principal Findings We isolated bacterial endophytes from field-grown Solanum nigrum; characterized PGP traits (ACC deaminase activity, IAA production, phosphate solubilization and seedling colonization); and determined their effects on their host, S. nigrum, as well as on another Solanaceous native plant, Nicotiana attenuata. In S. nigrum, a majority of isolates that promoted root growth were associated with ACC deaminase activity and IAA production. However, in N. attenuata, IAA but not ACC deaminase activity was associated with root growth. Inoculating N. attenuata and S. nigrum with known PGP bacteria from a culture collection (DSMZ) reinforced the conclusion that the PGP effects are not highly conserved. Conclusions/ Significance We conclude that natural endophytic bacteria with PGP traits do not have general and predictable effects on the growth and fitness of all host plants, although the underlying mechanisms are conserved.
New secoiridoid Glycosides from the Roots of Picrorhiza Scrophulariiflora

Three new secoiridoid glycosides, named picrogentiosides A (1), B (2) and C (3), have been isolated from the underground parts of Picrorhiza Scrophulariiflora, together with the two known compounds plantamajoside (4) and plantainoside D (5). Their structures were established by spectroscopic analyses and comparisons with data from related compounds. A pilot pharmacological study showed that picrogentiosides A (1) and B (2) have an immunomodulatory effect in vitro.
Impact of Gender and Age on performing Search Tasks Online

More and more people use the Internet to work on duties of their daily work routine. To find the right information online, Web search engines are the tools of their choice. Apart from finding facts, people use Web search engines to also execute rather complex and time consuming search tasks. So far search engines follow the one-for-all approach to serve its users and little is known about the impact of gender and age on people's Web search behavior. In this article we present a study that examines (1) how female and male web users carry out simple and complex search tasks and what are the differences between the two user groups, and (2) how the age of the users impacts their search performance. The laboratory study was done with 56 ordinary people each carrying out 12 search tasks. Our findings confirm that age impacts behavior and search performance significantly, while gender influences were smaller than expected.
Particle motion in a liquid film rimming the inside of a partially filled rotating cylinder

Both lighter- and hydrophobic heavier-than-liquid particles will float on liquid–air surfaces. Capillary forces cause the particles to cluster in typical situations identified here. This kind of clustering causes particles to segregate into islands and bands of high concentrations in thin liquid films rimming the inside of a slowly rotating cylinder partially filled with liquid. A second regime of particle segregation, driven by secondary motions induced by off-centre gas bubbles in a more rapidly rotating cylinder at higher filling levels, is identified. A third regime of segregation of bidisperse suspensions is found in which two layers of heavier-than-liquid particles that stratify when there is no rotation, segregate into alternate bands of particles when there is rotation.
Ecto-5′ Nucleotidase (CD73)-Mediated Adenosine Generation and Signaling in Murine Cardiac Allograft Vasculopathy

Ecto-5′-nucleotidase (CD73) catalyzes the terminal phosphohydrolysis of 5′-adenosine monophosphate and is widely expressed on endothelial cells where it regulates barrier function. Because it is also expressed on lymphocytes, we hypothesized that it modulates vascular immune regulation under homeostatic conditions and dysregulation under stress conditions such as cardiac allotransplantation. In a heterotopic cardiac allotransplantation model, CD73 deficiency in either donors or recipients resulted in decreased graft survival and the development of cardiac allograft vasculopathy, suggesting a contribution of CD73 on both graft-resident and circulating cells in vasculopathy pathogenesis. Vascular perturbations incited by lack of CD73 included loss of graft barrier function and diminished graft expression of the A2B adenosine receptor (A2BAR), with a concordant exacerbation of the acute inflammatory and immune responses. The importance of CD73 in modulating endothelial–lymphocyte interaction was further demonstrated in allomismatched in vitro coculture experiments. Either genetic deletion or pharmacological blockade of CD73 increased transendothelial lymphocyte migration and inflammatory responses, suggesting that CD73 plays a critical role to suppress transendothelial leukocyte trafficking through its enzymatic activity. In addition, antagonism of A2BAR caused a significant increase in vascular leakage, and agonism of A2BAR resulted in marked prolongation of graft survival and suppression of cardiac allograft vasculopathy development. These data suggest a new paradigm in which phosphohydrolysis of adenosine monophosphate by CD73 on graft-resident or circulating cells diminishes transendothelial leukocyte trafficking and mitigates inflammatory and immune sequelae of cardiac transplantation via the A2BAR.
Creation of Bt Rice Expressing a Fusion Protein of Cry1Ac and Cry1I-Like using a Green Tissue-Specific Promoter

ABSTRACT The insecticidal genes from Bacillus thuringiensis Berliner (Bt) have long been successfully used for development of insect-resistant rice. However, commercial planting of Bt rice has been delayed by the concern over food safety, although no scientific evidence is ever found to justify the concern. To address this safety concern, we developed a transgenic insect-resistant rice line using a green tissue promoter to minimize the Bt protein expression in the rice seeds. The Bt protein expressed in the rice was a fusion protein of two different Bt toxins, Cry1Ac and Cry1I-like protein. The fusion of the two toxins may be helpful to delay the development of insect resistance to Bt rice. Laboratory and field bioassays demonstrated that the transgenic rice plants created by this study were highly active against the rice leaf folder Cnaphalocrocis medinalis (Guenée) and the striped stem borer Chilo suppressalis (Walker). Western analysis indicated that the fusion protein was specifically expressed in green tissues but not in seeds. Therefore, the transgenic rice created in this study should be useful to mitigate the food safety concern and to delay the development of insect resistance.
Longitudinal characterization of biomarkers for spinal muscular atrophy

Recent advances in understanding Spinal Muscular Atrophy (SMA) etiopathogenesis prompted development of potent intervention strategies and raised need for sensitive outcome measures capable of assessing disease progression and response to treatment. Several biomarkers have been proposed; nevertheless, no general consensus has been reached on the most feasible ones. We observed a wide range of measures over 1 year to assess their ability to monitor the disease status and progression.