Miracle-dz/UniFAR-FTUs huggingface dataset:
Adverse reactions to Mycobacterium bovis bacille Calmette-Guérin vaccination against tuberculosis in Iranian children

Purpose There are considerable variations in the number of adverse reaction reports related to vaccine from different countries. The aim of this study was to review the development of adverse reactions to bacille Calmette-Guérin (BCG) vaccination among hospitalized patients in an Iranian referral hospital. Materials and Methods We identified hospitalized patients with BCG complications in Pediatric Infectious Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran during January 2007-April 2009. Data on demographics, clinical features, laboratory findings, personal history (including vaccination history), family history, and outcomes were retrieved from medical records. Results There were 46 cases with BCG complication during the 2 years period. All of the children received vaccination at birth. Twenty-eight patients (61%) were male. The mean age of the patients was 13.5 ±11.3 months (range, 1 to 52 months; median, 10 months). The majority of children (57%) with BCG complication were less than 1 year old. Among hospitalized patients due to BCG complications, suppurative lymphadenitis was occurred in 28 children (61%) and lymphadenopathy was seen in 9 children (20%). Disseminated BCG was detected in 8 patients (17%) and only 1 child (2%) was presented with abscess. In 7% (n = 3) of children, the family history of BCG complications were positive. Conclusion The most common side effect of the BCG vaccine in our study was suppurative lymphadenitis. Disseminated BCG infection in complications leading to hospitalization in our study was 17%. With regard to the difficulty in implementing such a guideline in settings where BCG is given to all newborns, registration of Iranian primary immunodeficiency disorders (PID) patients would be helpful to increase the awareness of medical community of Iran to investigate underlying disease. In addition, BCG vaccination should postpone in each newborn with a family history of PID until the definite condition has been ruled out.
Phenomenology of Turbulent Dynamo Growth and Saturation

With a nonlocal shell model of magnetohydrodynamic turbulence we investigate numerically the turbulent dynamo action for low and high magnetic Prandtl numbers (Prm). The results obtained in the kinematic regime and along the way to dynamo saturation are understood in terms of a phenomenological approach based on the local () or nonlocal () nature of the energy transfers. In both cases, the magnetic energy grows at a small scale and saturates as an inverse “cascade. ”
Genome-Wide Scan Informed by Age-Related Disease Identifies Loci for Exceptional Human Longevity

We developed a new statistical framework to find genetic variants associated with extreme longevity. The method, informed GWAS (iGWAS), takes advantage of knowledge from large studies of age-related disease in order to narrow the search for SNPs associated with longevity. To gain support for our approach, we first show there is an overlap between loci involved in disease and loci associated with extreme longevity. These results indicate that several disease variants may be depleted in centenarians versus the general population. Next, we used iGWAS to harness information from 14 meta-analyses of disease and trait GWAS to identify longevity loci in two studies of long-lived humans. In a standard GWAS analysis, only one locus in these studies is significant (APOE/TOMM40) when controlling the false discovery rate (FDR) at 10%. With iGWAS, we identify eight genetic loci to associate significantly with exceptional human longevity at FDR < 10%. We followed up the eight lead SNPs in independent cohorts, and found replication evidence of four loci and suggestive evidence for one more with exceptional longevity. The loci that replicated (FDR < 5%) included APOE/TOMM40 (associated with Alzheimer’s disease), CDKN2B/ANRIL (implicated in the regulation of cellular senescence), ABO (tags the O blood group), and SH2B3/ATXN2 (a signaling gene that extends lifespan in Drosophila and a gene involved in neurological disease). Our results implicate new loci in longevity and reveal a genetic overlap between longevity and age-related diseases and traits, including coronary artery disease and Alzheimer’s disease. iGWAS provides a new analytical strategy for uncovering SNPs that influence extreme longevity, and can be applied more broadly to boost power in other studies of complex phenotypes.
The Aminopeptidase CD13 Induces Homotypic Aggregation in Neutrophils and Impairs Collagen Invasion

Aminopeptidase N (CD13) is a widely expressed cell surface metallopeptidase involved in the migration of cancer and endothelial cells. Apart from our demonstration that CD13 modulates the efficacy of tumor necrosis factor-α-induced apoptosis in neutrophils, no other function for CD13 has been ascribed in this cell. We hypothesized that CD13 may be involved in neutrophil migration and/or homotypic aggregation. Using purified human blood neutrophils we confirmed the expression of CD13 on neutrophils and its up-regulation by pro-inflammatory agonists. However, using the anti-CD13 monoclonal antibody WM-15 and the aminopeptidase enzymatic inhibitor bestatin we were unable to demonstrate any direct involvement of CD13 in neutrophil polarisation or chemotaxis. In contrast, IL-8-mediated neutrophil migration in type I collagen gels was significantly impaired by the anti-CD13 monoclonal antibodies WM-15 and MY7. Notably, these antibodies also induced significant homotypic aggregation of neutrophils, which was dependent on CD13 cross-linking and was attenuated by phosphoinositide 3-kinase and extracellular signal-related kinase 1/2 inhibition. Live imaging demonstrated that in WM-15-treated neutrophils, where homotypic aggregation was evident, the number of cells entering IL-8 impregnated collagen I gels was significantly reduced. These data reveal a novel role for CD13 in inducing homotypic aggregation in neutrophils, which results in a transmigration deficiency; this mechanism may be relevant to neutrophil micro-aggregation in vivo.
On the streaming motions of haloes and galaxies

A simple model is described of how objects of different masses stream towards each other as they cluster gravitationally. The model shows how the mean streaming velocity of dark matter particles is related to the motions of the parent dark matter haloes. It also provides a reasonably accurate description of how the pairwise velocity dispersion of dark matter particles differs from that of the parent haloes. The analysis is then extended to describe the streaming motions of galaxies. This shows explicitly that the streaming motions measured in a given galaxy sample depend on how the sample was selected, and shows how to account for this dependence on sample selection. In addition, we show that the pairwise dispersion should also depend on sample type. Our model predicts that, on small scales, redshift-space distortions should affect red galaxies more strongly than blue.
Response of optical hydrogen lines to beam heating I. Electron beams

Context. Observations of hydrogen Balmer lines in solar flares remain an important source of information on flare processes in the chromosphere during the impulsive phase of flares. The intensity profiles of optically thick hydrogen lines are determined by the temperature, density, and ionisation structure of the flaring atmosphere, by the plasma velocities and by the velocity distribution of particles in the line formation regions. Aims. We investigate the role of non-thermal electrons in the formation regions of H α , H β , and H γ lines in order to unfold their influence on the formation of these lines. We concentrate on pulse-beam heating varying on a subsecond timescale. Furthermore, we theoretically explore possibility that a new diagnostic tool exists indicating the presence of non-thermal electrons in the flaring chromosphere based on observations of optical hydrogen lines. Methods. To model the evolution of the flaring atmosphere and the time-dependent hydrogen excitation and ionisation, we used a 1-D radiative hydrodynamic code combined with a test-particle code that simulates the propagation, scattering, and thermalisation of a power-law electron beam in order to obtain the flare heating and the non-thermal collisional rates due to the interaction of the beam with the hydrogen atoms. To not bias the results by other effects, we calculate only short time evolutions of the flaring atmosphere and neglect the plasma velocities in the radiative transfer. Results. All calculated models have shown a time-correlated response of the modelled Balmer line intensities on a subsecond timescale, with a subsecond timelag behind the beam flux. Depending on the beam parameters, both line centres and wings can show pronounced intensity variations. The non-thermal collisional rates generally result in an increased emission from a secondary region formed in the chromosphere. Conclusions. Despite the clear influence of the non-thermal electron beams on the Balmer line intensity profiles, we were not able on the basis of our simulations to produce any unambiguous diagnostic of non-thermal electrons in the line-emitting region, which would be based on comparison of individual Balmer line intensity profiles. However, fast line intensity variations, well-correlated with the beam flux variations, represent an indirect indication of pulsating beams.
Adaptive Unicast and Multicast Protocols for Mobile Ad Hoc Networks

The combination of wireless communication infrastructure and portable computing devices has laid the foundation for a new network computing paradigm, called mobile computing, which permits access to information and collaboration with others while on the move [30]. Wireless mobile networks are characterized by severe constraints on resources, such as bandwidth and battery power, and by rapid fluctuations in availability of these resources; this makes it difficult for the system software to provide guaranteed quality-of-service at levels required by many distributed and collaborative applications. Further, mobility adds a new dimension to the distributed computing paradigm which has implications for specification, design, verification, and implementation of both system and application software [41]. A challenging issue is to determine the interface and the guarantees that system software can efficiently provide to developers of both location-independent and location-dependent (context-aware) [47] applications on mobile networks [42]. This has resulted in research on adaptive applications and system software which can gracefully respond to changes in operating conditions [4]. My current research is focused on developing adaptive solutions for resource allocation, location management, unicast and multicast routing protocols and caching schemes in wireless networks for supporting mobile computing.
Single event-related changes in cerebral oxygenated hemoglobin using word game in schizophrenia

Neuroimaging studies have been conducted using word generation tasks and have shown greater hypofrontality in patients with schizophrenia compared with healthy subjects. In this study, we compared the characteristics of oxygenated hemoglobin changes involved in both phonological and categorical verbal fluency between 35 outpatients with schizophrenia and 35 healthy subjects during a Japanese “shiritori” task using single-event-related near-infrared spectroscopy. During this task, the schizophrenic patients showed significantly smaller activation in the prefrontal cortex area than the controls. In addition, a significant positive correlation was obtained between oxygenated hemoglobin changes (prefrontal cortex area, inferior parietal area) and the severity of positive psychiatric symptoms. It is possible that hypofrontality of patients may be a diagnostic assistance tool for schizophrenia, and that the relationship between activation and positive syndrome scores may be of help in predicting functional outcome in patients.
Multi-stage coupon incentive-based demand response in two-settlement electricity markets

This paper extends our recent work and proposes a multi-stage coupon incentive-based demand response (M-CIDR) in two-settlement electricity markets. In contrast to the realtime pricing (RTP) or critical peak pricing (CPP) demand response programs, M-CIDR continues to offer a flat rate to retail customers and additional voluntary incentives to induce demand response. Compared with single-stage CIDR, a unit commitment model is employed so that the inter-temporal constraints can be considered conveniently. Theoretical analysis shows the benefits of the proposed scheme in two-settlement electricity markets. And numerical illustration is performed in the IEEE 30 bus system. The results show that during the periods with price spikes, the proposed M-CIDR can effectively induce demand response, reduce market clearing prices, obtain a social welfare which is close to that in the RTP scheme.
Selective distribution of GABAA receptor subtypes in mouse spinal dorsal horn neurons and primary afferents

In the spinal cord dorsal horn, presynaptic GABAA receptors (GABAARs) in the terminals of nociceptors as well as postsynaptic receptors in spinal neurons regulate the transmission of nociceptive and somatosensory signals from the periphery. GABAARs are heterogeneous and distinguished functionally and pharmacologically by the type of α subunit variant they contain. This heterogeneity raises the possibility that GABAAR subtypes differentially regulate specific pain modalities. Here, we characterized the subcellular distribution of GABAAR subtypes in nociceptive circuits by using immunohistochemistry with subunit‐specific antibodies combined with markers of primary afferents and dorsal horn neurons. Confocal laser scanning microscopy analysis revealed a distinct, partially overlapping laminar distribution of α1–3 and α5 subunit immunoreactivity in laminae I–V. Likewise, a layer‐specific pattern was evident for their distribution among glutamatergic, γ‐aminobutyric acid (GABA)ergic, and glycinergic neurons (detected in transgenic mice expressing vesicular glutamate transporter 2–enhanced green fluorescent protein [vGluT2–eGFP], glutamic acid decarboxylase [GAD]67–eGFP, and glycine transporter 2 (GlyT2)–eGFP, respectively). Finally, all four subunits could be detected within primary afferent terminals. C‐fibers predominantly contained either α2 or α3 subunit immunoreactivity; terminals from myelinated (Aβ/Aδ) fibers were colabeled in roughly equal proportion with each subunit. The presence of axoaxonic GABAergic synapses was determined by costaining with gephyrin and vesicular inhibitory amino acid transporter to label GABAergic postsynaptic densities and terminals, respectively. Colocalization of the α2 or α3 subunit with these markers was observed in a subset of C‐fiber synapses. Furthermore, gephyrin mRNA and protein expression was detected in dorsal root ganglia. Collectively, these results show that differential GABAAR distribution in primary afferent terminals and dorsal horn neurons allows for multiple, circuit‐specific modes of regulation of nociceptive circuits. J. Comp. Neurol. 520:3895–3911, 2012. © 2012 Wiley Periodicals, Inc.
TeamUEvora at Clef eHealth 2014 Task2a

We present our rst participation in a ShARe/CLEF eHealth Lab contributing for task 2a. Task 2 is an extension of the 2013 lab task 1 and consists of information extraction from clinical texts for Disease/Disorder Template Filling; task 2a aims at predicting each at- tribute's normalization value. This work constitutes a preliminary approach to the problem of extract- ing and handling information from clinical texts. More than getting a good result, our priority was to get a rst hint on the questions and problems that are posed within this area. For that, we developed a system that combines information from cTAKES output and the training corpus. The performance was measured using ac- curacy. Our system ranked 7th with an accuracy of 0.802, a F1 of 0.214, a precision of 0.217 and a recall value of 0.211.
Clustering and Routing in Mobile Wireless Networks

In this paper we propose several new clustering algorithms for nodes in a mobile ad hoc network. We propose to combine two known approaches into a single clustering algorithm which considers connectivity as a primary and lower ID as secondary criteria for selecting clusterheads. Several inherently collision-free clustering algorithms are then designed based on a depth first search (DFS) traversal of nodes in the network. These algorithms are initialized by any node and are fully distributed. They create and maintain k-clusters, in which any node is at distance at most k hops from the clusterhead. In the clustering process, each node is either a clusterhead, a covered or undecided node. In the basic k-cluster algorithm, each undecided visited node in DFS declares itself a clusterhead and covers all its k-hop neighbors. In the highest connectivity k-cluster algorithms, each undecided visited node checks all its undecided k-hop neighbors and chooses one with the largest connectivity to be its clusterhead. We also describe algorithms for modifying cluster structure in the presence of topological changes. The efficiency of the clustering algorithms is tested by measuring the average number of created clusters, the number of border nodes, and the cluster size in random unit graphs. In a recently proposed GEDIR (geographic distance routing) algorithm, each node forwards the packet to one of its neighbors that is closest to the destination. We propose A-GEDIR (Avoidance GEDIR) algorithm for clustered networks, in which node currently holding the packet selects the second closest neighbor to destination if the best choice is a clusterhead (and if second choice leads closer to destination). The proposed variation addresses the problem of higher energy consumption of clusterhead nodes. The delivery rates, hop counts and transmission ratios for clusterheads and other nodes in GEDIR and AGEDIR algorithms are then compared.
Archival Analysis Of Enterprise Resource Planning Systems: The Current State And Future Directions

Research on Enterprise Resource Planning (ERP) Systems is becoming a well-established research theme in Information Systems (IS) research. Enterprise Resource Planning Systems, given its unique differentiations with other IS applications, have provided an interesting backdrop to test and re-test some of the key and fundamental concepts in IS. While some researchers have tested well-established concepts of technology acceptance, system usage and system success in the context of ERP Systems, others have researched how new paradigms like cloud computing and social media integrate with ERP Systems. Moreover, ERP Systems provided the context for cross disciplinary research such as knowledge management, project management and business process management research. Almost after two-decades since its inception in IS research, this paper provides a critique of 198 papers published on ERP Systems since 2006-2012. We observe patterns on ES research, provide comparisons to past studies and provide future research directions.
SiGe building blocks for on-chip X-Band T/R modules

This paper presents a T/R (transmit/receive) module for X-Band phased arrays using a 0.25 μm SiGe BiCMOS process technology. The T/R module consists of a T/R switch, a SPDT switch, a power amplifier (PA), and a low noise amplifier (LNA). The T/R switch and SPDT switch are implemented using CMOS transistors whereas the PA and LNA are based on SiGe HBTs. The designed T/R switch achieves minimum 3.2 dB insertion loss, maximum 34.8 dB isolation and has a P1dB of 28.2 dBm at 10 GHz. The SPDT switch has less than 2.2 dB loss at X-Band and occupies 0.17 mm2 chip area. The PA achieves a small-signal gain of 25 dB and a saturated output power of 23.2 dBm with 25% PAE in a 3 GHz bandwidth. Lastly, the LNA has a gain more than 19 dB and 1.65 dB (mean) noise figure at X-Band. More detailed analysis with extended results and utilized techniques will be presented at the conference.
Vibration energy harvesting by magnetostrictive material

A new class of vibration energy harvester based on magnetostrictive material (MsM), Metglas 2605SC, is designed, developed and tested. It contains two submodules: an MsM harvesting device and an energy harvesting circuit. Compared to piezoelectric materials, the Metglas 2605SC offers advantages including higher energy conversion efficiency, longer life cycles, lack of depolarization and higher flexibility to survive in strong ambient vibrations. To enhance the energy conversion efficiency and alleviate the need of a bias magnetic field, Metglas ribbons are transversely annealed by a strong magnetic field along their width direction. To analyze the MsM harvesting device a generalized electromechanical circuit model is derived from Hamilton’s principle in conjunction with the normal mode superposition method based on Euler–Bernoulli beam theory. The MsM harvesting device is equivalent to an electromechanical gyrator in series with an inductor. In addition, the proposed model can be readily extended to a more practical case of a cantilever beam element with a tip mass. The energy harvesting circuit, which interfaces with a wireless sensor and accumulates the harvested energy into an ultracapacitor, is designed on a printed circuit board (PCB) with plane dimension 25 mm × 35 mm. It mainly consists of a voltage quadrupler, a 3 F ultracapacitor and a smart regulator. The output DC voltage from the PCB can be adjusted within 2.0–5.5 V. In experiments, the maximum output power and power density on the resistor can reach 200 µW and 900 µW cm−3, respectively, at a low frequency of 58 Hz. For a working prototype under a vibration with resonance frequency of 1.1 kHz and peak acceleration of 8.06 m s−2 (0.82 g), the average power and power density during charging the ultracapacitor can achieve 576 µW and 606 µW cm−3, respectively, which compete favorably with piezoelectric vibration energy harvesters.