Miracle-dz/UniFAR-FTUs huggingface dataset:
The Set1/COMPASS Histone H3 Methyltransferase Helps Regulate Mitosis With the CDK1 and NIMA Mitotic Kinases in Aspergillus nidulans

Mitosis is promoted and regulated by reversible protein phosphorylation catalyzed by the essential NIMA and CDK1 kinases in the model filamentous fungus Aspergillus nidulans. Protein methylation mediated by the Set1/COMPASS methyltransferase complex has also been shown to regulate mitosis in budding yeast with the Aurora mitotic kinase. We uncover a genetic interaction between An-swd1, which encodes a subunit of the Set1 protein methyltransferase complex, with NIMA as partial inactivation of nimA is poorly tolerated in the absence of swd1. This genetic interaction is additionally seen without the Set1 methyltransferase catalytic subunit. Importantly partial inactivation of NIMT, a mitotic activator of the CDK1 kinase, also causes lethality in the absence of Set1 function, revealing a functional relationship between the Set1 complex and two pivotal mitotic kinases. The main target for Set1-mediated methylation is histone H3K4. Mutational analysis of histone H3 revealed that modifying the H3K4 target residue of Set1 methyltransferase activity phenocopied the lethality seen when either NIMA or CDK1 are partially functional. We probed the mechanistic basis of these genetic interactions and find that the Set1 complex performs functions with CDK1 for initiating mitosis and with NIMA during progression through mitosis. The studies uncover a joint requirement for the Set1 methyltransferase complex with the CDK1 and NIMA kinases for successful mitosis. The findings extend the roles of the Set1 complex to include the initiation of mitosis with CDK1 and mitotic progression with NIMA in addition to its previously identified interactions with Aurora and type 1 phosphatase in budding yeast.
The intervening role of social worldviews in the relationship between the five‐factor model of personality and social attitudes

The present research investigates in a student (N = 183) and a voter sample (N = 276) whether the relationships between the Five‐Factor Model (FFM) personality dimensions and social attitudes (i.e. Right‐Wing Authoritarianism [RWA] and Social Dominance Orientation [SDO]) are mediated by social worldviews (i.e. dangerous and jungle worldviews). Two important results were obtained. First, the perception of the world as inherently dangerous and chaotic partially mediated the relationships of the personality dimensions Openness and Neuroticism and the social attitude RWA. Second, the jungle worldview completely mediated the relationships between Agreeableness and SDO, but considerable item overlap between the jungle worldview and SDO was also noted. It was further revealed that acquiescence response set and item overlap had an impact on social worldviews and attitudes, but that their relationships were hardly affected by these biases. The discussion focuses on the status of social worldviews to explain social attitudes. Copyright © 2006 John Wiley & Sons, Ltd.
A qualidade de vida de pessoas com deficiência mental leve

People with intellectual disability are often neglected even though it is a question of their own quality of life. Thus, this study aimed to know the opinion of 15 adults with mild intellectual disability related to their quality of life and the opinion of their caregivers about it with an instrument that evaluates quality of life (WHOQOL-Bref). The data were statistically analyzed and compared. The results show that the difference between the evaluations was small in the questions concerning satisfaction with the physical, psychological, social relation and environment welfares. People with disability' evaluation was few higher than their caregiver's evaluation. There weren't significant statistics difference between evaluations, so that we conclude that the people with intellectual disability are able to talk about their own lives with an optimistic view and a very realistic way.
Collateral Consequences of Imprisonment for Children, Communities, and Prisoners

Analyses of the effects of America's experiment with vastly increased use of imprisonment as a penal sanction typically focus on crime reduction and public spending. Little attention has been paid to collateral effects. Imprisonment significantly reduces later employment rates and incomes of exprisoners. In many urban communities, large fractions of young men attain prison records and are thus made less able to contribute to their communities and families. Less is known about the effects of a parent's imprisonment on children's development, though mainstream theories provide grounds for predicting those effects are substantial and deleterious. Until research begins to shed light on these questions, penal policy will continue to be set in ignorance of important ramifications of alternate policy options.
Quantitative and qualitative approaches to the study of mobility and scientific performance: a case study of a Spanish university

In this study we analyse the relationship between mobility and scientific performance in a Spanish university. We used different sources: an institutional database (Universitas XXI) to obtain information about the scientific activity and personal data of researchers, and bibliographic databases (WoS, ICYT and ISOC) to complete the study of scientific output. A select number of researchers was interviewed to gather additional information about the importance of mobility in the academic career and to obtain other subjective results from research stays. Through this quantitative and qualitative approach, we concluded that there is a strong relationship between mobility, productivity, visibility and international collaboration. We propose this methodology mix for the study of other academic institutions. Copyright , Beech Tree Publishing.
Persistence of Psychological Distress in Surgical Patients with Interest in Psychotherapy: Results of a 6-Month Follow-Up

Objectives This prospective observational study investigated whether self-reported psychological distress and alcohol use problems of surgical patients change between preoperative baseline assessment and postoperative 6-month follow-up examination. Patients with preoperative interest in psychotherapy were compared with patients without interest in psychotherapy. Methods A total of 1,157 consecutive patients from various surgical fields completed a set of psychiatric questionnaires preoperatively and at 6 months postoperatively, including Patient Health Questionnaire-4 (PHQ-4), Brief Symptom Inventory (BSI), Center for Epidemiologic Studies Depression Scale (CES-D), World Health Organization 5-item Well-Being Index (WHO-5), and Alcohol Use Disorder Identification Test (AUDIT). Additionally, patients were asked for their interest in psychotherapy. Repeated measure ANCOVA was used for primary data analysis. Results 16.7% of the patients were interested in psychotherapy. Compared to uninterested patients, they showed consistently higher distress at both baseline and month 6 regarding all of the assessed psychological measures (p’s between <0.001 and 0.003). At 6-month follow-up, neither substantial changes over time nor large time x group interactions were found. Results of ANCOVA’s controlling for demographic variables were confirmed by analyses of frequencies of clinically significant distress. Conclusion In surgical patients with interest in psychotherapy, there is a remarkable persistence of elevated self-reported general psychological distress, depression, anxiety, and alcohol use disorder symptoms over 6 months. This suggests high and chronic psychiatric comorbidity and a clear need for psychotherapeutic and psychiatric treatment rather than transient worries posed by facing surgery.
Sources of exposure to and public health implications of organophosphate pesticides.

OBJECTIVE To review the public health significance of organophosphate pesticide exposure in the United States of America. Since the situation of high organophosphate pesticide exposure and the concomitant health risks in the developing countries of the world is well known, this article seeks to highlight the public health significance of organophosphate exposure in the United States, where it is less common than in many other nations. Looking at the situation in the United States would serve to further emphasize the seriousness of organophosphate pesticide-related health issues in developing countries. METHODS A search for journal articles on organophosphate pesticides and organophosphate exposure was done on the PubMed electronic bibliographic database system of the National Library of Medicine of the United States. To supplement that search, information on organophosphate toxicity, biological monitoring, and regulation of pesticides was obtained from other published articles, textbooks, and relevant Internet sites. RESULTS Organophosphate pesticides are a group of chemicals that are mainly used in agriculture. Organophosphates inhibit the activity of both the cholinesterase (ChE) enzymes-red blood cell (RBC) ChE and serum ChE-resulting in the cholinergic features of organophosphate toxicity. A 50% reduction in serum ChE activity from the baseline is an indication of acute organophosphate toxicity. The RBC ChE activity, which is less rapidly depressed than the serum ChE activity, is a measure of chronic exposure to organophosphates. Exposures to organophosphates are broadly classified into two categories: occupational and environmental. Occupational exposures occur among agricultural workers (including migrant farmworkers), industrial workers, pest control exterminators, and other workers. Nonoccupational exposure affects a large segment of the general population in the United States. Residential exposures come from organophosphate pesticide use by exterminators and by household residents as well as from dietary and accidental exposures. Other environmental exposures occur in public places and areas close to farms, and exposures could also happen from organophosphate use in chemical warfare or terrorism. In the United States some organophosphate pesticides are restricted by the Environmental Protection Agency in order to protect humans, animals, and the environment. In addition, the Food Quality Protection Act regulates dietary exposure to pesticides, particularly for infants and children. CONCLUSIONS Organophosphate pesticides continue to pose a risk to human health in the United States. Biological monitoring should be used to strictly regulate occupational exposures to organophosphates and thus protect the health and safety of workers. Among the public there should be an increased awareness of environmental exposure to organophosphates as well as of the threat of chemical warfare or terrorism.
The Combined Effects of Weight Training and Plyometrics on Dynamic Leg Strength and Leg Power

The purpose of this study was to determine the effects of plyometric exercise (depth drops), combined with weight training, on dynamic leg strength and leg power. Plyometrics are exercises that force a rapid lengthening of muscle prior to contraction, to result in increased force output during contraction. Thirty-one volunteer university students were randomly assigned to three groups according to height of drop (1.1 m=high, 0.4 m=low and no height). Subjects in each group were classified in two conditions according to leg strength-body weight ratio (low=less than 2, and high=greater than 2). All groups were administered a dynamic leg strength test and Magaria anaerobic power test prior to and following an eight-week plyometric and weight training program. A two-way ANOVA (groups (3) x conditions (2)) revealed no significant differences between groups, conditions, and no significant interactions for leg strength and Magaria power scores. Independent T-tests for mean differences between pre- and post-test scores demonstrated significant gains in both strength and power for each group. It was concluded that participating in a combined 8-week program of plyometrics and weight training will improve leg strength and power. Furthermore, coaches and athletes should be apprised that neither the level of strength nor height of drop variables altered the resultant training effects of the combination program used in this study. The possibility of reducing the time between forced stretch at impact and initiation of contraction to improve plyometric training effects was discussed.
Microencapsulation of Bacteriophage Felix O1 into Chitosan-Alginate Microspheres for Oral Delivery

ABSTRACT This paper reports the development of microencapsulated bacteriophage Felix O1 for oral delivery using a chitosan-alginate-CaCl2 system. In vitro studies were used to determine the effects of simulated gastric fluid (SGF) and bile salts on the viability of free and encapsulated phage. Free phage Felix O1 was found to be extremely sensitive to acidic environments and was not detectable after a 5-min exposure to pHs below 3.7. In contrast, the number of microencapsulated phage decreased by 0.67 log units only, even at pH 2.4, for the same period of incubation. The viable count of microencapsulated phage decreased only 2.58 log units during a 1-h exposure to SGF with pepsin at pH 2.4. After 3 h of incubation in 1 and 2% bile solutions, the free phage count decreased by 1.29 and 1.67 log units, respectively, while the viability of encapsulated phage was fully maintained. Encapsulated phage was completely released from the microspheres upon exposure to simulated intestinal fluid (pH 6.8) within 6 h. The encapsulated phage in wet microspheres retained full viability when stored at 4°C for the duration of the testing period (6 weeks). With the use of trehalose as a stabilizing agent, the microencapsulated phage in dried form had a 12.6% survival rate after storage for 6 weeks. The current encapsulation technique enables a large proportion of bacteriophage Felix O1 to remain bioactive in a simulated gastrointestinal tract environment, which indicates that these microspheres may facilitate delivery of therapeutic phage to the gut.
The first half-century of nuclear transplantation

Fifty years after Briggs and King first succeeded in obtaining normal tadpoles from transplanted embryo nuclei in vertebrates, two general principles have emerged from work in amphibia and mammals. One is the conservation of the genome during cell differentiation. A small percentage of adult or differentiated cells have totipotent nuclei, and a much higher percentage of cells committed to one pathway of cell differentiation have multipotent nuclei. The other is the remarkable reprogramming capacity of cell, and especially egg, cytoplasm. The eventual identification of reprogramming molecules and mechanisms could facilitate a route toward cell replacement therapy in humans.
The crucial role of caspase‐9 in the disease progression of a transgenic ALS mouse model

Mutant copper/zinc superoxide dismutase (SOD1)‐overexpressing transgenic mice, a mouse model for familial amyotrophic lateral sclerosis (ALS), provides an excellent resource for developing novel therapies for ALS. Several observations suggest that mitochondria‐dependent apoptotic signaling, including caspase‐9 activation, may play an important role in mutant SOD1‐related neurodegeneration. To elucidate the role of caspase‐9 in ALS, we examined the effects of an inhibitor of X chromosome‐linked inhibitor of apoptosis (XIAP), a mammalian inhibitor of caspase‐3, ‐7 and ‐9, and p35, a baculoviral broad caspase inhibitor that does not inhibit caspase‐9. When expressed in spinal motor neurons of mutant SOD1 mice using transgenic techniques, XIAP attenuated disease progression without delaying onset. In contrast, p35 delayed onset without slowing disease progression. Moreover, caspase‐9 was activated in spinal motor neurons of human ALS subjects. These data strongly suggest that caspase‐9 plays a crucial role in disease progression of ALS and constitutes a promising therapeutic target.
Dual Cross-Attention Parkinson’s Disease Classification Using Vocal Feature Sets

Parkinson’s disease is a disabling condition that affects the quality of life of individuals with both motor and non-motor symptoms. Auditory disorders are one of the non-motor symptoms that individuals will face in the early stages of the disease. Therefore, the use of vocal features for early detection of Parkinson’s disease is a crucial aspect of diagnosis. This paper presents a novel approach to Parkinsonts disease diagnosis using vocal features and advanced neural network architectures. In this study, a structure based on dual cross-attention is introduced that combines features extracted from time-frequency representations, specifically the Wavelet Transform (WT) and Tunable Q factor Wavelet Transforms (TQWT), describing both temporal and frequency features of the audio signal simultaneously. Ultimately, a self-attention block is responsible for determining the class assignment. The results demonstrate that the proposed network performs well compared to existing networks in the context of Parkinson’s disease diagnosis.
The research assessment exercise 2001—insights and implications for accounting education research in the UK

Abstract Following the 2001 Research Assessment Exercise (RAE), details from the submissions of each institution were made available to the public for the first time via the Internet, thus facilitating a greater degree of scrutiny of the results than had hitherto been the case. The purpose of this paper is to contribute to the literature on the publishing patterns of UK academics by examining the accounting education submissions to the RAE 2001. The paper begins by discussing the RAE process in the UK and the findings of prior literature on publication patterns within accounting research in the UK in order to contextualise the examination of the RAE submissions in accounting education. In particular, the dominance of refereed journals over other publication outlets, the increasing prevalence of co-authorship and the characteristics of publishing academics are examined. The paper then reports on the methods used to analyse accounting education research submitted to the RAE 2001 and discusses the main findings. The implications of these findings are discussed in the concluding section.
Binge eating in an obese community sample.

OBJECTIVE The present study sought to examine the validity and utility of diagnostic criteria for binge-eating disorder (BED) by replicating and extending a study reported by de Zwaan and colleagues (International Journal of Eating Disorders, 15, 43-52, 1994). METHOD Four groups of obese individuals were selected from a large community-based sample of men and women: 33 women and 20 men with BED, 79 women and 40 men with subthreshold BED, 21 women and 39 men who reported recurrent overeating, and 80 female and 80 male normal controls. The groups were compared on measures of body image concern, dieting behavior, and associated psychological distress. RESULTS Individuals with BED were distinguishable from overeaters and normal controls on a number of psychological and behavioral variables. Few differences were found between subthreshold and full-syndrome BED, raising questions about the diagnostic validity of the frequency threshold. Men with BED did not differ from women with BED above and beyond the gender-related differences observed across all four groups. DISCUSSION Our findings support the view of BED as a distinct syndrome.
Categories of modules over an affine Kac-Moody algebra and the Kazhdan-Lusztig tensor product

To each category C of modules of finite length over a complex simple Lie algebra g, closed under tensoring with finite dimensional modules, we associate and study a category Aff(C)_\kappa of smooth modules (in the sense of Kazhdan and Lusztig [KL1]) of finite length over the corresponding affine Kac-Moody algebra in the case of central charge less than the critical level. Equivalent characterizations of these categories are obtained in the spirit of the works of Kazhdan-Lusztig [KL1] and Lian-Zuckerman [LZ1]. In the main part of this paper we establish a finiteness result for the Kazhdan-Lusztig tensor product which can be considered as an affine version of a theorem of Kostant [K]. It contains as special cases the finiteness results of Kazhdan, Lusztig [KL] and Finkelberg [F], and states that for any subalgebra f of g which is reductive in g the "affinization" of the category of finite length admissible (g, f) modules is stable under Kazhdan-Lusztig's tensoring with the "affinization" of the category of finite dimensional g modules (which is O_\kappa in the notation of [KL1, KL2, KL3]).
The GrADS Project: Software Support for High-Level Grid Application Development

Advances in networking technologies will soon make it possible to use the global information infrastructure in a qualitatively different way—as a computational as well as an information resource. As described in the recent book The Grid: Blueprint for a New Computing Infrastructure, this Grid will connect the nation’s computers, databases, instruments, and people in a seamless web of computing and distributed intelligence, which can be used in an on-demand fashion as a problem-solving resource in many fields of human endeavor—and, in particular, science and engineering. The availability of grid resources will give rise to dramatically new classes of applications, in which computing resources are no longer localized but, rather, distributed, heterogeneous, and dynamic; computation is increasingly sophisticated and multidisciplinary; and computation is integrated into our daily lives and, hence, subject to stricter time constraints than at present. The impact of these new applications will be pervasive, ranging from new systems for scientific inquiry, through computing support for crisis management, to the use of ambient computing to enhance personal mobile computing environments. To realize this vision, significant scientific and technical obstacles must be overcome. Principal among these is usability. The goal of the Grid Application Development Software (GrADS) project is to simplify distributed heterogeneous computing in the same way that the World Wide Web simplified information sharing over the Internet. To that end, the project is exploring the scientific and technical problems that must be solved to make it easier for ordinary scientific users to develop, execute, and tune applications on the Grid. In this paper, the authors describe the vision and strategies underlying the GrADS project, including the base software architecture for grid execution and performance monitoring, strategies and tools for construction of applications from libraries of grid-aware components, and development of innovative new science and engineering applications that can exploit these new technologies to run effectively in grid environments.
Specific Involvement of Human Parietal Systems and the Amygdala in the Perception of Biological Motion

To explore the extent to which functional systems within the human posterior parietal cortex and the superior temporal sulcus are involved in the perception of action, we measured cerebral metabolic activity in human subjects by positron emission tomography during the perception of simulations of biological motion with point-light displays. The experimental design involved comparisons of activity during the perception of goal-directed hand action, whole body motion, object motion, and random motion. The results demonstrated that the perception of scripts of goal-directed hand action implicates the cortex in the intraparietal sulcus and the caudal part of the superior temporal sulcus, both in the left hemisphere. By contrast, the rostrocaudal part of the right superior temporal sulcus and adjacent temporal cortex, and limbic structures such as the amygdala, are involved in the perception of signs conveyed by expressive body movements.