Miracle-dz/UniFAR-FTUs huggingface dataset:
Overlap Between Asthma and COPD: Where the Two Diseases Converge

Asthma and chronic obstructive pulmonary disease (COPD) are traditionally recognized as distinct diseases, with some clearly separate characteristic. Asthma originates in childhood, is associated with allergies and eosinophils, and is best treated by targeting inflammation, whereas COPD occurs in adults who smoke, involves neutrophils, and is best treated with bronchodilators and the removal of risk factors. However, the distinction between the two is not always clear. Patients with severe asthma may present with fixed airway obstruction, and patients with COPD may have hyperresponsiveness and eosinophilia. Recognizing and understanding these overlapping features may offer new insight into the mechanisms and treatment of chronic airway inflammatory diseases.
Identifying factors key to encouraging entrepreneurial intentions among seniors

Using the theory of planned behaviour (TPB), we examined the impact of age on entrepreneurial intention, with special focus on seniors. Using samples from France reflecting a broad age range, a negative relationship involving age and entrepreneurial intent was found. Consistent with TPB, attitude, social norms, and perceived behavioural control were all significantly associated with intent. Importantly however, the relative weight seniors gave these components differed from that of prime age participants. For seniors, the belief that they had the requisite competencies and resources needed to own a business was especially important. Seniors also expressed greater relative interest in social entrepreneurship. The implications of these findings for both researchers and public policy makers are considered. Copyright © 2015 ASAC. Published by John Wiley & Sons, Ltd. Resume Cet article s'appuie sur la theorie du comportement planifie (TPB) pour examiner l'impact de l'âge sur les intentions entrepreneuriales, notamment chez les personnes âgees. L'analyse d'echantillons collectes en France aupres de citoyens issus de tranches d'âge variees revele une relation negative entre l'âge et l'intention entrepreneuriale. Comme le montre la TPB, l'attitude, les normes sociales et le controle comportemental percu sont relies de facon significative a l'intention entrepreneuriale. Cependant, le poids relatif que les personnes âgees accordent a ces composantes differe de celui que lui accordent les jeunes. En effet, les premiers estiment qu'ils ont les competences et les ressources necessaires pour posseder une entreprise. Ils manifestent aussi un plus grand interet pour l'entrepreneuriat social. L'article s'acheve par un examen des implications des resultats a la fois pour les chercheurs et pour les decideurs politiques. Copyright © 2015 ASAC. Published by John Wiley & Sons, Ltd.
First detection of the blaOXA-23 gene in a multidrug-resistant A. baumannii clinical isolate from Cochabamba, Bolivia.

The University of the Basque Country UPV/EHU was the Institution where the research was conducted although the clinical data and preliminary experiments were done in the University of San Simon (Universidad Mayor de San Simon UMSS) and Viedma Hospital within a collaborative project. This work was supported by grant AE14/23 from the University of the Basque Country UPV/EHU. Thanks to Dr. Bruno Lopes, School of Medicine & Dentistry, University of Aberdeen, UK, for critically reading the manuscript.
Bone level changes around axial and tilted implants in full-arch fixed immediate restorations. Interim results of a prospective study.

PURPOSE The aim of this prospective study was to assess clinical outcomes and peri-implant bone level changes around tilted and axial implants supporting full-arch fixed immediate rehabilitations up to 60 months of loading. MATERIAL AND METHODS Forty-seven patients (22 women and 25 men) were included in the study. Each patient received a full-arch fixed bridge supported by two axial and two distal tilted implants. Loading was applied within 48 hours of surgery. Patients were scheduled for follow-up at 6, 12, 18, 24 months, and annually up to 5 years. At each follow-up, plaque level and bleeding scores were assessed and radiographic evaluation of marginal bone level change was performed. Periapical radiographs were taken using a paralleling technique, and subsequently scanned at 600 dpi. An image analysis software was used to assess bone level. RESULTS A total of 33 mandibles and 16 maxillae were rehabilitated (two patients received a fixed prosthesis in both arches). One hundred ninety-six Nobel Biocare implants of 4 mm diameter were placed. The mean follow-up duration was 52.8 months (range 30-66 months) in the mandible, and 33.8 months (range 22-40 months) in the maxilla. All subjects attended the scheduled follow-up visits. No implant was lost. No significant difference in marginal bone loss was found between axial and tilted implants in both jaws, at each follow-up. No significant difference in bone loss was found between mandible and maxilla, for both axial and tilted implants at each comparable time frame, although slightly higher mean values were always found for the mandible. CONCLUSION The use of tilted implants in the immediate rehabilitation of fully edentulous jaws is safe and is not associated to a higher marginal bone loss as compared to axially placed implants.
Colorectal carcinoma tumour budding and podia formation in the xenograft microenvironment

Tumour budding and podia formation are well-appreciated in surgical pathology as an aggressive invasion phenotype of colorectal carcinoma cells that is attained in the microenvironment of the invasive margin. In this study, we addressed how tumour budding and podia formation feature in xenografts. Primary colorectal carcinomas (N = 44) of various molecular types (sporadic standard type, high-degree microsatellite-unstable, CpG island methylator phenotype) were transplanted subcutaneously into T and B cell-deficient NSG mice, making possible immunohistochemistry with routine surgical pathology antibodies. Tumor budding and podia formation were both appreciably present in the xenografts. Quantitative evaluations of cytokeratin immunostains of primaries and their corresponding xenografts showed a reduction of tumour buds in the xenografts. Furthermore, in xenografts tumour cells were completely negative by pSTAT3 immunohistochemistry, indicating absence of cytokine/chemokine signalling, but nuclear β-catenin and SMAD4 immunostainings as read-out of wnt and BMP pathway activation, respectively, were maintained. Carcinoma cells in most xenografts retained immunostaining of at least some nuclei by immunohistochemistry with antibodies against pERK1/2. K-ras/B-raf mutational status did not correlate with tumour budding or podia formation in the xenografts. Our results indicate that tumour budding and podia formation can be modelled by xenografting, and in NSG mice it can be studied with the same immunohistochemical methods as used for primaries in surgical pathology. Dysregulation of wnt and BMP signalling appears to be transferred into the xenograft microenvironment, but not cytokine/chemokine signalling.
Sleep duration in the first months after ST elevation myocardial infarction: an independent predictor of all-cause mortality.

BACKGROUND Sleep duration and sleep quality affect patients' general condition and self-reported health status. AIM The aims of this study were:(1) to describe the clinical characteristic of ST-elevation myocardial infarction (STEMI) patients who sleep too little or too much; and(2) to determine whether sleep duration is independently associated with a higher risk of all-cause mortality. METHODS We enrolled into the study 407 consecutive patients admitted with a diagnosis of STEMI. All patients were asked for sleep duration in the first three months after being discharged from the hospital. According to the sleep duration, we divided patients into three groups: A - the reference category defined as 6-8 sleep hours, B - short sleep with < 6 h, and C - long sleep with > 8 h. RESULTS The final analysis covered 379 patients (271 males; mean age 59.4 ± 10.61). 36 (9.5%) patients slept less than 6 h, 26 (6.9%) slept more than 8 h per night. The all-cause three-year mortality was 1.9% in the reference category, 13.9% in patients who slept less than 6 h, and 30.8% in patients who slept more than 8 h per night (p < 0.0001). In the multiple logistic regression analysis, short (OR 10.2, 95% CI 2.1-50, p = 0.004) and long sleep duration (OR 33.3, 95% CI 6.8-163.4, p < 0.001) were strong and independent predictors of all-cause mortality. CONCLUSIONS Too short and especially too long duration of sleep in the first months after myocardial infarction are strong,independent predictors of all-cause mortality.
The perceiving process and mystical orientation: a study in psychological type theory among 16- to 18-year-old students

This study builds on earlier work to test Ross' thesis that the perceiving process is core to individual differences in religious experience. Data provided by 149 adolescents (16–18 years of age) who completed the Francis Psychological Type Scales alongside the Mystical Orientation Scale supported Ross' thesis. Intuitive types recorded a significantly higher score than sensing types on the index of mystical orientation, while no significant differences were recorded in terms of the judging process (thinking and feeling), the orientations (extraversion and introversion), or the attitudes (judging and perceiving).
Mouse Tissues that Undergo Neoplastic Progression after K-Ras Activation Are Distinguished by Nuclear Translocation of phospho-Erk1/2 and Robust Tumor Suppressor Responses

Mutation of K-Ras is a frequent oncogenic event in human cancers, particularly cancers of lungs, pancreas, and colon. It remains unclear why some tissues are more susceptible to Ras-induced transformation than others. Here, we globally activated a mutant oncogenic K-Ras allele (K-RasG12D) in mice and examined the tissue-specific effects of this activation on cancer pathobiology, Ras signaling, tumor suppressor, DNA damage, and inflammatory responses. Within 5 to 6 weeks of oncogenic Ras activation, mice develop oral and gastric papillomas, lung adenomas, and hematopoietic hyperproliferation and turn moribund. The oral, gastric, and lung premalignant lesions display activated extracellular signal–regulated kinases (Erk)1/2 and NF-κB signaling as well as activated tumor suppressor and DNA damage responses. Other organs such as pancreas, liver, and small intestine do not exhibit neoplastic progression within 6 weeks following K-RasG12D activation and do not show a potent tumor suppressor response. Even though robust Erk1/2 signaling is activated in all the tissues examined, the pErk1/2 distribution remains largely cytoplasmic in K-RasG12D–refractory tissues (pancreas, liver, and intestines) as opposed to a predominantly nuclear localization in K-RasG12D–induced neoplasms of lung, oral, and gastric mucosa. The downstream targets of Ras signaling, pElk-1 and c-Myc, are elevated in K-RasG12D–induced neoplastic lesions but not in K-RasG12D–refractory tissues. We propose that oncogenic K-Ras–refractory tissues delay oncogenic progression by spatially limiting the efficacy of Ras/Raf/Erk1/2 signaling, whereas K-Ras–responsive tissues exhibit activated Ras/Raf/Erk1/2 signaling, rapidly form premalignant tumors, and activate potent antitumor responses that effectively prevent further malignant progression. Mol Cancer Res; 10(6); 845–55. ©2012 AACR.
Allogeneic stem cell transplantation for refractory acute myeloid leukemia: a single center analysis of long‐term outcome

For patients with refractory acute myeloid leukemia (AML), allogeneic stem cell transplantation (alloSCT) represents the only curative approach. We here analyzed the long‐term outcome of 131 consecutive patients with active AML, which was either primary refractory or unresponsive to salvage chemotherapy, transplanted at our center between 1997 and 2013. After a median follow‐up of 48 months for the surviving patients, disease‐free survival (DFS) at 5 yr post alloSCT was 26% (94% CI: 17–35). Relapses, most of which occurred within the first 2 yr from transplant, were the predominant cause of treatment failure affecting 48% (95%CI: 40–58) of patients, whereas non‐relapse mortality was 26% (95%CI: 20–36) at 5 yr and thereafter. A marrow blast count ≥20% before alloSCT was an independent prognosticator associated with an inferior DFS (HR: 1.58, P = 0.027), whereas the development of chronic graft‐versus‐host disease (cGvHD) predicted an improved DFS (HR 0.21, P < 0.001) and a decreased relapse incidence (HR: 0.18, P = 0.026), respectively. These results indicate that alloSCT represents a curative treatment option in a substantial proportion of patients with refractory AML. A pretransplant blast count <20% before alloSCT and the development of cGvHD are the most important predictors of long‐term disease control.
Optimal Virtual Monochromatic Images for Evaluation of Normal Tissues and Head and Neck Cancer Using Dual-Energy CT

BACKGROUND AND PURPOSE: Dual-energy CT is not used routinely for evaluation of the head and neck, and there is no consensus on the optimal virtual monochromatic image energies for evaluating normal tissues or head and neck cancer. We performed a quantitative evaluation to determine the optimal virtual monochromatic images for visualization of normal tissues, head and neck squamous cell carcinoma, and lymphadenopathy. MATERIALS AND METHODS: Dual-energy CT scans from 10 healthy patients and 30 patients with squamous cell carcinoma were evaluated at different virtual monochromatic energy levels ranging from 40 to 140 keV. The signal-to-noise ratios of muscles at 6 different levels, glands (parotid, sublingual, submandibular, and thyroid), 30 tumors, and 17 metastatic lymph nodes were determined as measures of optimal image quality. Lesion attenuation and contrast-to-noise ratios (compared with those of muscle) were evaluated to assess lesion conspicuity. RESULTS: The optimal signal-to-noise ratio for all the tissues was at 65 keV (P < .0001). However, tumor attenuation (P < .0001), attenuation difference between tumor and muscles (P = .03), and lesion contrast-to-noise ratios (P < .0001) were highest at 40 keV. CONCLUSIONS: The optimal image signal-to-noise ratio is at 65 keV, but tumor conspicuity compared with that of muscle is greatest at 40 keV. Optimal evaluation of the neck may be best achieved by a multiparametric approach, with 65-keV virtual monochromatic images providing the best overall image quality and targeted use of 40-keV virtual monochromatic images for tumor evaluation.
Analysis of the reliability of a subset of change metrics for defect prediction

In this paper, we describe an experiment, which analyzes the relative importance and stability of change metrics for predicting defects for 3 releases of the Eclipse project. The results indicate that out of 18 change metrics 3 metrics contain most information about software defects. Moreover, those 3 metrics remain stable across 3 releases of the Eclipse project. A comparative analysis with the full model shows that the prediction accuracy is not too much affected by using a subset of 3 metrics and the recall even improves.
Online reviews can predict long-term returns of individual stocks

Online reviews are feedback voluntarily posted by consumers about their consumption experiences. This feedback indicates customer attitudes such as affection, awareness and faith towards a brand or a firm and demonstrates inherent connections with a company's future sales, cash flow and stock pricing. However, the predicting power of online reviews for long-term returns on stocks, especially at the individual level, has received little research attention, making a comprehensive exploration necessary to resolve existing debates. In this paper, which is based exclusively on online reviews, a methodology framework for predicting long-term returns of individual stocks with competent performance is established. Specifically, 6,246 features of 13 categories inferred from more than 18 million product reviews are selected to build the prediction models. With the best classifier selected from cross-validation tests, a satisfactory increase in accuracy, 13.94%, was achieved compared to the cutting-edge solution with 10 technical indicators being features, representing an 18.28% improvement relative to the random value. The robustness of our model is further evaluated and testified in realistic scenarios. It is thus confirmed for the first time that long-term returns of individual stocks can be predicted by online reviews. This study provides new opportunities for investors with respect to long-term investments in individual stocks.
Prediction of cholera dynamics in Haiti following the passage of Hurricane Matthew

Following the landfall of Hurricane Matthew in Haiti on October 3, 2016, an increase of suspected cholera cases was reported in both the southern part of the island (with Grande-Anse and Le Sud departments reporting 1349 and 1533 cases respectively between 5 October and 6 November) and also in the capital, Port-au-Prince (438 cases reported over the same period). The hurricane caused the displacement of about 175,000 people, the vast majority of which remained in their department of origin; however, about 10% appear to have displaced to the capital Port-au-Prince. In this context, a mass OCV vaccination campaign was planned, starting on November 8 and targeting 816,999 individuals in Grande-Anse and Le Sud. The aim of this study is to provide additional information to health actors responding to the post-hurricane cholera outbreak in Haiti. To this end, we calibrated a mechanistic model of cholera transmission on currently available data for Haiti in order to forecast the spatio-temporal dynamics of the cholera epidemic at the departmental level from November 2016 to January 2017. Model outputs have been translated into operational recommendations, with a focus on the scheduled OCV campaign.
The Main Sequence at z ∼ 1.3 Contains a Sizable Fraction of Galaxies with Compact Star Formation Sizes: A New Population of Early Post-starbursts?

Atacama Large Millimeter/submillimeter Array (ALMA) measurements for 93 Herschel-selected galaxies at 1.1 ≤ z ≤ 1.7 in COSMOS reveal a sizable (>29%) population with compact star formation (SF) sizes, lying on average >×3.6 below the optical stellar mass (M⋆)–size relation of disks. This sample widely spans the star-forming main sequence (MS), having 108 ≤ M⋆ ≤ 1011.5 M⊙ and 20 ≤ star formation rate (SFR) ≤ 680 M⊙ yr−1. The 32 size measurements and 61 upper limits are measured on ALMA images that combine observations of CO(5–4), CO(4–3), CO(2–1), and λobs ∼ 1.1–1.3 mm continuum, all tracing the star-forming molecular gas. These compact galaxies have instead normally extended Kband sizes, suggesting strong specific SFR gradients. Compact galaxies comprise the 50 ± 18% of MS galaxies at M⋆ > 1011M⊙. This is not expected in standard bimodal scenarios, where MS galaxies are mostly steadily growing extended disks. We suggest that compact MS objects are early post-starburst galaxies in which the merger-driven boost of SF has subsided. They retain their compact SF size until either further gas accretion restores premerger galaxy-wide SF, or until becoming quenched. The fraction of merger-affected SF inside the MS seems thus larger than anticipated and might reach ∼50% at the highest M⋆. The presence of large galaxies above the MS demonstrates an overall poor correlation between galaxy SF size and specific SFR.
Exploring possibilities for characterization of power transformer insulation by frequency response analysis (FRA)

This paper explores the possibility for using frequency response analysis (FRA) technique to characterize the quality of transformer insulation. For this purpose, a single-phase and a three-phase lumped parameter circuit models were developed. The single-phase model represents a transformer without a laminated core, whereas the three-phase model represents a real transformer with core. Calculations of frequency dependent circuit parameters are presented and the effects imparted on the frequency response by different loss mechanisms (in insulation, in windings and in core) are discussed. The simulations are compared with results of measurements on real objects. It is shown that FRA could be used for insulation diagnostics if the measurements were of high enough quality.
Please Stop Permuting Features: An Explanation and Alternatives

This paper advocates against permute-and-predict (PaP) methods for interpreting black box functions. Methods such as the variable importance measures proposed for random forests, partial dependence plots, and individual conditional expectation plots remain popular because of their ability to provide model-agnostic measures that depend only on the pre-trained model output. However, numerous studies have found that these tools can produce diagnostics that are highly misleading, particularly when there is strong dependence among features. Rather than simply add to this growing literature by further demonstrating such issues, here we seek to provide an explanation for the observed behavior. In particular, we argue that breaking dependencies between features in hold-out data places undue emphasis on sparse regions of the feature space by forcing the original model to extrapolate to regions where there is little to no data. We explore these effects through various settings where a ground-truth is understood and find support for previous claims in the literature that PaP metrics tend to over-emphasize correlated features both in variable importance and partial dependence plots, even though applying permutation methods to the ground-truth models do not. As an alternative, we recommend more direct approaches that have proven successful in other settings: explicitly removing features, conditional permutations, or model distillation methods.
The dimensions of accessibility to online information: implications for implementing office information systems

Prior research has found a positive correlation between the perceived accessibility of information and information use. The underlying dimensions of information accessibility, however, have not been investigated empirically. The present field study measures end-user perceptions of three online information retrieval systems and one electronic mail system. User ratings of the four systems are collected and factor-analyzed. The results suggest that (1)physical access to a terminal and access to the actual information system are independent dimensions, (2) that accessibility is a multidimensional concept encompassing physical access to a terminal and the system, the command language, and the ability to retrieve the desired information successfully, and (3) that perceptions of accessibility are a function of prior user experience with online systems. In order to facilitate the acceptance of office information systems, organizations need to provide extensive support and training when the system is introduced, as well as ready physical access to the system over the course of its useful life.
PiNet: A Permutation Invariant Graph Neural Network for Graph Classification

We propose an end-to-end deep learning learning model for graph classification and representation learning that is invariant to permutation of the nodes of the input graphs. We address the challenge of learning a fixed size graph representation for graphs of varying dimensions through a differentiable node attention pooling mechanism. In addition to a theoretical proof of its invariance to permutation, we provide empirical evidence demonstrating the statistically significant gain in accuracy when faced with an isomorphic graph classification task given only a small number of training examples. We analyse the effect of four different matrices to facilitate the local message passing mechanism by which graph convolutions are performed vs. a matrix parametrised by a learned parameter pair able to transition smoothly between the former. Finally, we show that our model achieves competitive classification performance with existing techniques on a set of molecule datasets.