Miracle-dz/UniFAR-FTUs huggingface dataset:
A dynamic analysis of the LO noise transfer mechanism in a Rb-cell frequency standard

Frequency noise of the local oscillator at even harmonics of the modulation frequency is known to contribute to the short-term instability of passive frequency standards. The mechanism by which this noise transfer takes place in Rb-cell standards is described here in a comprehensive approach that includes both signal theory methods and a time-dependent quantum mechanical analysis. The resulting calculated transfer coefficients for the various even harmonics are discussed in relationship with measured coefficients in an actual experiment.
Functional resolution of duplicated hoxb5 genes in teleosts

The duplication-degeneration-complementation (DDC) model predicts that subfunctionalization of duplicated genes is a common mechanism for their preservation. The additional Hox complexes of teleost fish constitute a good system in which to test this hypothesis. Zebrafish have two hoxb complexes, with two hoxb5 genes, hoxb5a and hoxb5b, the expression patterns of which suggest subfunctionalization of an ancestral hoxb5 gene. We characterized conserved non-coding elements (CNEs) near the zebrafish hoxb5 genes. One CNE, J3, is only retained in the hoxb5a locus, whereas the others, J1 and J2, are present in both hoxb5 loci. When tested individually, the enhancer activity of individual CNEs, including J3, extensively overlapped and did not support a role in subfunctionalization. By contrast, reporter transgene constructs encompassing multiple CNEs were able to target reporter gene expression to unique domains of hoxb5a and hoxb5b expression. The deletion of J3 from the hoxb5a locus resulted in expression that approached that of hoxb5b, whereas its insertion in the hoxb5b locus increased reporter expression and rendered it more similar to that of hoxb5a. Our results highlight the importance of interactions between CNEs in the execution of complementary subfunctions of duplicated genes.
Towards Automated Melanoma Screening: Exploring Transfer Learning Schemes

Deep learning is the current bet for image classification. Its greed for huge amounts of annotated data limits its usage in medical imaging context. In this scenario transfer learning appears as a prominent solution. In this report we aim to clarify how transfer learning schemes may influence classification results. We are particularly focused in the automated melanoma screening problem, a case of medical imaging in which transfer learning is still not widely used. We explored transfer with and without fine-tuning, sequential transfers and usage of pre-trained models in general and specific datasets. Although some issues remain open, our findings may drive future researches.
Application-level document caching in the Internet

With the increasing demand for document transfer services such as the World Wide Web comes a need for better resource management to reduce the latency of documents in these systems. To address this need, we analyze the potential for document caching at the application level in document transfer services. We have collected traces of actual executions of Mosaic, reflecting over half a million user requests for WWW documents. Using those traces, we study the tradeoffs between caching at three levels in the system, and the potential for use of application-level information in the caching system. Our traces show that while a high hit rate in terms of URLs is achievable, a much lower hit rate is possible in terms of bytes, because most profitably-cached documents are small. We consider the performance of caching when applied at the level of individual user sessions, at the level of individual hosts, and at the level of a collection of hosts on a single LAN. We show that the performance gain achievable by caching at the session level (which is straightforward to implement) is nearly all of that achievable at the LAN level (where caching is more difficult to implement). However, when resource requirements are considered, LAN level caching becomes muck more desirable, since it can achieve a given level of caching performance using a much smaller amount of cache space. Finally, we consider the use of organizational boundary information as an example of the potential for use of application-level information in caching. Our results suggest that distinguishing between documents produced locally and those produced remotely can provide useful leverage in designing caching policies, because of differences in the potential for sharing these two document types among multiple users. <<ETX>>
Ventricular Volume Reduction Procedures

Abstract Although partial left ventriculectomy (PLV) has been abandoned in many institutions, a few hospitals continue to perform it with a relatively favorable outcome. Other volume reduction procedures have become popular with renewed interest in ventricular reshaping to improve function. Although recent refined selection criteria have improved survival with PLV, earlier unpredictable results prompted less invasive procedures based on the same physiologic concept of reducing radius or wall tension by wrapping, piercing, or clasping. These new techniques are not only less invasive but also reversible and adjustable and appear safer for less symptomatic patients at risk of progressive heart failure. Nonetheless, mechanisms of action and degrees of volume reduction and/or restriction need to be delineated before widespread clinical application. (J CARD SURG 2003;18 (Suppl 2):S69‐S75)
Refractory Duodenal Crohn's Disease Successfully Treated with Infliximab

Crohn's disease (CD) may involve any part of the gastrointestinal tract, from the mouth to the anus. Approximately >90% of cases occur in the small bowel and colon. Upper gastrointestinal involvement, especially duodenal manifestation, is relatively rare. Therefore, adequate medical treatment for duodenal CD has not yet been established. We report a case of CD with duodenal involvement. A 46-year-old man with Crohn's ileocolitis presented to our hospital with right upper quadrant pain. An endoscopy showed a deep excavated ulcer with deformity at the duodenal bulb, and he was initially treated with azathioprine (1 mg/kg), Pentasa (3.0 g/day), and a proton pump inhibitor for 1 year. However, the deep ulcer did not heal. Therefore, infliximab infusion therapy was initiated, and the duodenal lesion completely resolved on follow-up esophagogastroduodenoscopy. We report a case of duodenal CD that completely resolved following infliximab infusion, with a review of the literature.
Fund Manager Use of Public Information: New Evidence on Managerial Skills

We show theoretically that the responsiveness of a fund manager's portfolio allocations to changes in public information decreases in the manager's skill. We go on to estimate this sensitivity ("RPI") as the "R"-super-2 of the regression of changes in a manager's portfolio holdings on changes in public information using a panel of U.S. equity funds. Consistent with "RPI" containing information related to managerial skills, we find a strong inverse relationship between "RPI" and various existing measures of performance, and between "RPI" and fund flows. We also document that both fund- and manager-specific attributes affect "RPI". Copyright 2007 by The American Finance Association.
Cell membrane electroporation- Part 1: The phenomenon

Each biological cell, trillions of which build our bodies, is enveloped by its plasma membrane. Composed largely of a bilayer (double layer) of lipids just two molecules thick (about 5 nm), and behaving partly as a liquid and partly as a gel, the cell plasma membrane nonetheless separates and protects the cell from its surrounding environment very reliably and stably. Embedded within the lipid bilayer, also quite stably, are a number of different proteins, some of which act as channels and pumps, providing a pathway for transporting specific molecules across the membrane. Without these proteins, the membrane would be a largely impenetrable barrier. Electrically, the cell plasma membrane can be viewed as a thin insulating sheet surrounded on both sides by aqueous electrolyte solutions. When exposed to a sufficiently strong electric field, the membrane will undergo electrical breakdown, which renders it permeable to molecules that are otherwise unable to cross it. The process of rendering the membrane permeable is called membrane electroporation. Unlike solid insulators, in which an electrical breakdown generally causes permanent structural change, the membrane, with its lipids behaving as a two-dimensional liquid, can spontaneously return to its prebreakdown state. If the exposure is sufficiently short and the membrane recovery sufficiently rapid for the cell to remain viable, electroporation is termed reversible; otherwise, it is termed irreversible. Since its discovery [1]���[3], electroporation has steadily gained ground as a useful tool in various areas of medicine and biotechnology. Today, reversible electroporation is an established method for introducing chemotherapeutic drugs into tumor cells (electrochemotherapy) [4]. It also offers great promise as a technique for gene therapy without the risks caused by viral vectors (DNA electrotransfer) [5]. In clinical medicine, irreversible electroporation is being investigated as a method for tissue ablation (nonthermal electroablation) [6], whereas in biotechnology, it is useful for extraction of biomolecules [7] and for microbial deactivation, particularly in food preservation [8]. This article, the first in a series of three focusing on electroporation, describes the phenomenon at the molecular level of the lipid bilayer, and then proceeds to the cellular level, explaining how exposure of a cell as a whole to an external electric field results in an inducement of voltage on its plasma membrane, its electroporation, and transport thorough the electroporated membrane. The second article will review the most important and promising applications of electroporation, and the third article will focus on the hardware for electroporation (pulse generators and electrodes) and on the need for standards, safety, and certification.
Fast and precise localization at stop intersections

This article presents a practical solution for fast and precise localization of a vehicle's position and orientation with respect to stop sign controlled intersections based on video sequences and mapped data. It consists of two steps. First, an intersection map is generated offline based on street-level imagery and GPS data, collected by a vehicle driving through an intersection from different directions. The map contains both landmarks for localization and information about stop line positions. This information is used in the second step to precisely and efficiently derive a vehicle's pose in real-time when approaching a mapped intersection. At this point, we only need coarse GPS information to be able to load the proper map data.coarse GPS information to be able to load the proper map data. The experimental results show this approach is able to successfully localize a vehicle at stop intersections with decimeter accuracy under various weather conditions and after several months between the map data collection and the test drive. The proposed method enables a variety of functions for future driver assistance systems, such as stop line violation warning, advanced adaptive cruise control/ trafficJam assist functions in cities, or autonomous driving.
Beaming in Gamma-Ray Bursts: Evidence for a Standard Energy Reservoir

We present a comprehensive sample of all gamma-ray burst (GRB) afterglows with known distances, and we derive their conical opening angles based on observed broadband breaks in their light curves. Within the framework of this conical jet model, we correct for the geometry and we find that the gamma-ray energy release is narrowly clustered around 5 × 1050 ergs. We draw three conclusions. First, the central engines of GRBs release energies that are comparable to ordinary supernovae. Second, the broad distribution in fluence and luminosity for GRBs is largely the result of a wide variation of opening angles. Third, only a small fraction of GRBs are visible to a given observer, and the true GRB rate is several hundred times larger than the observed rate.
Examination of Coaches' Self-Efficacy: Preliminary Analysis of the Coaching Efficacy Scale

The purpose of the present study was to examine the psychometric properties of the Coaching Efficacy Scale, which measures coaches' beliefs about their capacity to affect the learning and performance of their athletes on Game Strategy, Motivation, Teaching Technique, and Character Building. 230 Greek male team coaches (M = 37.6 yr. ± 6.2) with 5.5 yr. (SD = 4.8) of experience completed the Greek translation of the scale. A first-order confirmatory factor analysis supported the basic factorial structure of the scale. Examination of a higher order model of an overall coaching efficacy factor showed satisfactory fit, using second-order confirmatory factor analysis. Moreover, the scale showed satisfactory Cronbach α of . 82 and 30-day test-retest reliability of . 73. Significant differences between experienced and less experienced coaches, defined by mean score, were found on Teaching Technique and overall self-efficacy factors, with more experienced coaches having significantly higher scores. Results supported the reliability and validity of the Greek version of the scale.
Identification of wallaby milk whey proteins separated by two‐dimensional electrophoresis, using amino acid analysis and sequence tagging

Micropreparative two‐dimensional polyacrylamide gel electrophoresis has been used to separate milk whey proteins from the Tammar wallaby (Macropus eugenii). We have used a combination of amino acid analysis and N‐terminal sequence tagging as a rapid and sensitive method to identify the major whey proteins. Using these techniques, we confidently identified α‐lactalbumin and late lactation protein. While these are the only two M. eugenii whey proteins with a corresponding SWISS‐PROT entry, we demonstrate that by using amino acid analysis and matching across species boundaries, we can identify previously unsequenced conserved wallaby whey proteins including β‐lactoglobulin and serum albumin.
Added Value of Contrast-Enhanced Ultrasound on Biopsies of Focal Hepatic Lesions Invisible on Fusion Imaging Guidance

Objective To assess whether contrast-enhanced ultrasonography (CEUS) with Sonazoid can improve the lesion conspicuity and feasibility of percutaneous biopsies for focal hepatic lesions invisible on fusion imaging of real-time ultrasonography (US) with computed tomography/magnetic resonance images, and evaluate its impact on clinical decision making. Materials and Methods The Institutional Review Board approved this retrospective study. Between June 2013 and January 2015, 711 US-guided percutaneous biopsies were performed for focal hepatic lesions. Biopsies were performed using CEUS for guidance if lesions were invisible on fusion imaging. We retrospectively evaluated the number of target lesions initially invisible on fusion imaging that became visible after applying CEUS, using a 4-point scale. Technical success rates of biopsies were evaluated based on histopathological results. In addition, the occurrence of changes in clinical decision making was assessed. Results Among 711 patients, 16 patients (2.3%) were included in the study. The median size of target lesions was 1.1 cm (range, 0.5–1.9 cm) in pre-procedural imaging. After CEUS, 15 of 16 (93.8%) focal hepatic lesions were visualized. The conspicuity score was significantly increased after adding CEUS, as compared to that on fusion imaging (p < 0.001). The technical success rate of biopsy was 87.6% (14/16). After biopsy, there were changes in clinical decision making for 11 of 16 patients (68.8%). Conclusion The addition of CEUS could improve the conspicuity of focal hepatic lesions invisible on fusion imaging. This dual guidance using CEUS and fusion imaging may affect patient management via changes in clinical decision-making.
Intraocular Pressure-Lowering Activity of NCX 470, a Novel Nitric Oxide-Donating Bimatoprost in Preclinical Models.

PURPOSE The prostaglandin F2alpha (PGF2α) analogue bimatoprost lowers intraocular pressure (IOP) by increasing uveoscleral outflow at doses shown to elicit redness of the eye. With the aim to enhance the IOP-lowering effect of bimatoprost we studied NCX 470 [(S,E)-1-((1R,2R,3S,5R)-2-((Z)-7-(ethylamino)-7-oxohept-2-enyl)-3,5-dihydroxycyclopentyl)-5-phenylpent-1-en-3-yl 6-(nitrooxy)hexanoate], a dual-acting compound combining bimatoprost with nitric oxide (NO) known to mainly act via relaxation of trabecular meshwork and Schlemm's canal. METHODS New Zealand white rabbits with transient hypertonic saline-induced IOP elevation (tOHT-rabbits), cynomolgus monkeys with laser-induced ocular hypertension (OHT-monkeys), and normotensive dogs (ONT-dogs) were used. The levels of NCX 470, bimatoprost, and bimatoprost acid were determined in aqueous humor (AH), cornea (CR), and iris/ciliary body (ICB) by liquid chromatography-mass spectrometry/mass (LC-MS/MS), while cGMP in AH and ICB was monitored using an enzyme immunoassay (EIA) kit in pigmented Dutch Belted rabbits. RESULTS NCX 470 (0.14%, 30 μL) lowered IOP in tOHT-rabbits with an E(max) of -7.2 ± 2.8 mm Hg at 90 minutes. Bimatoprost at equimolar dose (0.1%, 30 μL) was noneffective in this model. NCX 470 (0.042%, 30 μL) was more effective than equimolar (0.03%, 30 μL) bimatoprost in ONT-dogs (IOP change, -5.4 ± 0.7 and -3.4 ± 0.7 mm Hg, respectively, P < 0.05) and in OHT-monkeys (IOP change, -7.7 ± 1.4 and -4.8 ± 1.7 mm Hg, respectively, P < 0.05) at 18 hours post dosing. NCX 470 (0.042%, 30 μL) or bimatoprost (0.03%, 30 μL) resulted in similar bimatoprost acid exposure in AH, CR, and ICB while cGMP was significantly increased in AH and ICB at 18 and 24 hours after NCX 470 dosing. CONCLUSIONS NCX 470 lowers IOP more than equimolar bimatoprost in three animal models of glaucoma by activating PGF2α and NO/cGMP signaling pathways.
Subsequent Pregnancy After Gestational Diabetes Mellitus

OBJECTIVE—The purpose of this study was to determine the frequency of recurrent gestational diabetes mellitus (GDM) and to find risk factors that can predict the recurrence of GDM in Korean women with previous GDM. RESEARCH DESIGN AND METHODS—We evaluated women who had GDM in an index pregnancy (1993–2001) and a subsequent pregnancy by 2003. An oral glucose tolerance test (OGTT) was performed during the index pregnancy and 2 months postpartum. The recurrence rate of GDM was assessed among 111 women who had a subsequent pregnancy. Multivariate logistic regression analysis was used to identify independent predictors of recurrent GDM. RESULTS—The frequency of recurrent GDM in subsequent pregnancies was 45.0% (95% CI 35.6–54.4%). Women with impaired fasting glucose and/or impaired glucose tolerance 2 months postpartum were at increased risk for recurrent GDM (relative risk 2.31, 95% CI 1.24–4.30). Higher BMI before the subsequent pregnancy (P = 0.024), higher fasting glucose concentration (P = 0.007) 2 months postpartum, and lower 1-h insulin concentration (P = 0.004) of the diagnostic OGTT in the index pregnancy were independent risk factors for recurrence of GDM in subsequent pregnancies. CONCLUSIONS—GDM recurred in nearly half of subsequent pregnancies in Korean women. Fasting glucose 2 months postpartum might be a clinically valuable predictor of recurrent GDM risk.
Green Infrastructure: The Effects of Urban Rail Transit on Air Quality

The transportation sector is a major source of air pollution worldwide, yet little is known about the effects of transportation infrastructure on air quality. This paper quantifies the effects of one major type of transportation infrastructure—urban rail transit—on air quality using the sharp discontinuity in ridership on opening day of a new rail transit system in Taipei. We find that the opening of the Metro reduced air pollution from one key tailpipe pollutant, carbon monoxide, by 5 to 15 percent. Little evidence that the opening of the Metro affected ground level ozone pollution is found however. (JEL L92,
Circulation of Venusian Atmosphere at 90–110 km Based on Apparent Motions of the O2 1.27 μm Nightglow From VIRTIS‐M (Venus Express) Data

The paper is devoted to the investigation of Venus mesosphere circulation at 90–110 km altitudes, where tracking of the O2(a1Δg) 1.27 μm nightglow is practically the only method of studying the circulation. The images of the nightglow were obtained by VIRTIS‐M on Venus Express over the course of more than 2 years. The resulting global mean velocity vector field covers the nightside between latitudes 75°S–20°N and local time 19–5 h. The main observed mode of circulation is two opposite flows from terminators to midnight; however, the wind speed in the eastward direction from the morning side exceeds the westward (evening) by 20–30 m/s, and the streams “meet” at 22.5 ± 0.5 h. The influence of underlying topography was suggested in some cases: Above mountain regions, flows behave as if they encounter an “obstacle” and “wrap around” highlands. Instances of circular motion were discovered, encompassing areas of 1,500–4,000 km.
Segmenting CT prostate images using population and patient-specific statistics for radiotherapy

This paper presents a new deformable model using both population and patient-specific statistics to segment the prostate from CT images. There are two novelties in the proposed method. First, a modified scale invariant feature transform (SIFT) local descriptor, which is more distinctive than general intensity and gradient features, is used to characterize the image features. Second, an online training approach is used to build the shape statistics for accurately capturing intra-patient variation, which is more important than inter-patient variation for prostate segmentation in clinical radiotherapy. Experimental results show that the proposed method is robust and accurate, suitable for clinical application.
Nuclear diacylglycerol kinase‐ζ is a negative regulator of cell cycle progression in C2C12 mouse myoblasts

The nucleus contains diacylglycerol kinases (DGKs), i.e., the enzymes that, by converting diacylglycerol (DG) into phosphatidic acid, terminate DG‐dependent events. It has been demonstrated that nuclear DGK‐ζ interferes with cell cycle progression. We previously reported that nuclear DGK‐ζ expression increased during myogenic differentiation, whereas its down‐regulation impaired differentiation. Here, we evaluated the possible involvement of nuclear DGK‐ζ in cell cycle progression of C2C12 myoblasts. Overexpression of a wild‐type DGK‐ζ, which mainly localized to the nucleus (but not of a kinase dead mutant or of a mutant that did not enter the nucleus), blocked the cells in the G1 phase of the cell cycle, as demonstrated by in situ analysis of biotinylated‐16‐dUTP incorporated into newly synthesized DNA and by flow cytometry. In contrast, down‐regulation of endogenous DGK‐ζ by short interfering RNA (siRNA) increased the number of cells in both the S and G2/M phases of the cell cycle. Cell cycle arrest of cells overexpressing wild‐type DGK‐ζ was accompanied by decreased levels of retino‐blastoma protein phosphorylated on Ser‐807/811. Down‐regulation of endogenous DGK‐ζ, using siRNA, prevented the cell cycle block characterizing C2C12 cell myogenic differentiation. Overall, our results identify nuclear DGK‐ζ as a key determinant of cell cycle progression and differentiation of C2C12 cells. —Evan‐gelisti, C. , Tazzari, P. L. , Riccio, M. , Fiume, R. , Ho‐zumi, Y. , Fala, F. , Goto, K. , Manzoli, L. , Cocco, L. , Martelli, A. M. Nuclear diacylglycerol kinase‐ζ is a negative regulator of cell cycle progression in C2C12 mouse myoblasts. FASEB J. 21, 3297–3307 (2007)