Miracle-dz/UniFAR-FTUs huggingface dataset:
Molecular gas in the galaxy cluster Abell 262. CO observations of UGC 1347 and other galaxies of the cluster

We present millimeter CO line emission observations of 12 galaxies within the Abell 262 cluster, together with L FIR data, in the context of a possible molecular gas deficiency within the region of the cluster center. Several indications of the presence of such a deficiency are highlighted and connected to a model of cirrus-like cloud stripping. The model predicts a drop in the average 100 μ m flux density of galaxies in the core of the cluster compared to the average 100 μ m flux density in the outer regions, which is actually indicated in the IRAS data of the cluster members. This drop is explained by the decrease in the total hydrogen column density N (H) and, therefore, also includes a decrease in the molecular gas content. In addition to results for the global CO content of the galaxy sample, high-resolution interferometric CO(1-0) observations of one of the cluster members, UGC 1347, exemplify the spatial distribution of the molecular gas in a galaxy of the cluster. With these observations, it was possible to confirm the existence of a bright off-nuclear CO-emission source and to derive molecular masses and line ratios for this source and the nucleus.
A case study on crack propagation law of cement stabilised macadam base

ABSTRACT Based on the indoor crack monitoring test, the feasibility of monitoring base crack with sensing optical fibre and the appropriate optical fibre category are studied in detail. Through the field monitoring test of cement stabilised macadam, the crack development law in the early stage of cement stabilised base layer was researched. The test results show that the proposed sensing fibre can be used in researching the crack development law of cement stabilised macadam base. The initiation of crack in cement stabilised macadam base occurs mainly in the first 3 days after construction, in which the dry shrinkage crack is dominant. The development of the dry shrinkage probably ended in about 30 days. The dry shrinkage stress is the main factor of crack initiation and crack spacing. The influence of thermal stress on early crack spacing is very weak, and the thermal stress strongly affects the crack width. The thermal cracks basically appear in the location where the dry shrinkage stress displays peaks during the dry shrinkage phase. When the subbase and base layers were constructed continuously, the transverse cracks in cement stabilised macadam are always penetrating cracks.
Cyclophosphamide in Progressive Membranous Glomerulopathy: Pro and Con

To the Editors: Dr. Charlson and her colleagues have made an important contribution toward understanding the rational use of exercise for osteoarthritis (1). However, their statement that "sessions included light stretching and strengthening exercises" merits some elaboration. Stretching and strengthening have many descriptors in addition to light (for example, isometric, maximal contraction, passive, and so forth) (2). Furthermore, various types of stretching and strengthening may be effective in arthritis treatment (3, 4) independent of ambulation. Perhaps the authors could elaborate on the nature of the light stretching and strengthening in their study and their relevance to its outcome.
Ultrasonic bulk wave measurements on composite using fiber from recycled CFRP

This study investigates the velocity profile for both a virgin carbon fiber reinforced plastic (v-CFRP) and a reused fiber CFRP (rf-CFRP) which exhibit quasi-isotropy; all samples have 3 iterations of symmetry type [0, -45, +45, 90]s. An isotropic virgin CFRP (v-CFRP), produced by using a hand layup process, is presented along with a pyrolysis recycling process (at 600oC) designed to extract the carbon fibers. A virgin carbon fiber mat with a similar architecture was also thermally conditioned under the same pyrolysis conditions. Both resultant carbon fiber mats were used to produce the rf-CFRPs. Ultrasonic wave velocities at different angles of incidence for both v-CFRP and rf-CFRP were recorded. In the case of v-CFRP, two samples were studied and it was recorded that the velocity for both a longitudinal wave and transverse wave remained relatively constant up until these waves completely attenuated at observed angles, indicating what would be expected from an isotropic sample. A close relationship in terms of waves speed was also recorded for the two v-CFRP samples. In the case of rf-CFRP, the longitudinal wave velocities were generally less closely related when compared to the v-CFRP, with a maximum of approximately 32% difference being recorded. The transverse wave velocity was also found to decrease incident angle indicating sample anisotropy. The authors suggest that the more severe decreasing velocity with increasing incident angle, when compared to v-CFRP, may be caused by resin impregnation issues and not by changes that occur during the recycling process. Therefore, a hypothesis that both the rf-CFRP and the V-CFRP will return a similar wave profile given an identical resin fiber content is put forward.
The DExD/H-box ATPase Prp2p destabilizes and proofreads the catalytic RNA core of the spliceosome

Prp2p is a DEAH-box protein known to be essential for final rearrangements within the spliceosome prior to catalysis. This study provides evidence that Prp2p in addition to destabilizing protein components of the spliceosome also functions to reconfigure snRNA residues to achieve a catalytic conformation.
Insights on Observability and Identifiability Properties of Induction Motors at Steady-State

Abstract It has been recently shown in the literature that there exists a local solution to the problem of observing induction motor fluxes and identifying constant load torque and rotor/stator resistances from stator currents/voltages and rotor speed measurements. The corresponding adaptive observer is characterized by persistency of excitation conditions which are guaranteed to be satisfied in the typical case of constant motor speed and flux modulus and non-zero electro-magnetic torque and by sufficient stator resistance identifiability conditions at steady-state. The aim of this paper is to provide an elegant observability/identifiability analysis which interprets those requirements and clearly confirms that, under those conditions, the rotor fluxes and the three critical parameters can be actually (locally) reconstructed from the output measurements.
Surface characteristics and cell adhesion: a comparative study of four commercial dental implants.

PURPOSE The aims of this study were to compare surface properties of four commercial dental implants and to compare those implant systems' cell adhesion, which may be affected by the surface properties, and to provide scientific information on the selection of implants for clinicians. MATERIALS AND METHODS The surface properties of four commonly used dental implants (3i Nanotite™, Astra OsseoSpeed™, Nobel Biocare TiUnite®, and Straumann SLActive®) were studied using MicroSpy profiler, scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy, and Raman microspectroscopy. Primary mouse alveolar bone cells were cultured on the surface of implants from the four companies. After 48-hour culture, SEM in combination with a quantitative analysis of SEM images was used to examine the cell adhesion. Cell adhesion rates (ratios of cell surface to implant surface) among different systems were compared. RESULTS Distinct differences were found among these implants. Comparisons of roughness among three locations: flank, top, and valley within the same implant system, or in the same location among different implants were made. Generally Astra and Straumann systems showed the roughest surface, whereas 3i showed the smoothest surface. Multiple cracks were found on the surface of the Nobel Biocare system, which also had a dramatically lower level of titanium. In addition, rutile phase of titanium oxide was found in 3i, Astra, and Straumann systems, and anatase phase of titanium oxide was only detected in the Nobel Biocare system. After 48-hour culture, Astra and Straumann systems displayed the highest cell adhesion at the areas of flank, top, and valley of the implant surface. Primary cells also reached confluence on the valley, but significantly less in the 3i system. Nobel Biocare showed the least cell adhesion on the flank and valley. CONCLUSION Implant systems have distinct differences in surface properties, leading to different cell adhesion results. Further in vivo study is needed to study the impact of the surface characteristics and different cell adhesion on the osseointegration between implant and bone.
Genetics of childhood‐onset inflammatory bowel disease

&NA; Nearly a third of inflammatory bowel disease (IBD) patients present in childhood or adolescence, with epidemiological and natural history studies clearly demonstrating a rising incidence in this population. Although early‐onset disease has a distinct phenotype, such as more extensive disease at onset and rapid progression, two recent genome‐wide association studies (GWAS) carried out exclusively in this age group have demonstrated marked genetic similarities to adult disease. Although these parallels exist, this review will focus on the novel regions associated with early‐onset IBD susceptibility identified by these early‐onset GWAS. These new loci reaffirm the dysregulated pathways previously implicated in adult IBD pathogenesis and provide further insight into the pathophysiology of intestinal inflammation. The newly identified loci and expression data suggest mutations in genes encoding IL‐27, which is involved in Th17 effector cell physiology; MTMR3, which we demonstrate is an essential component of autophagy; and CAPN10, which is necessary in regulating endoplasmic reticulum stress. In addition, the roles of PSMG1, TNFRSF6B, ZMIZ1 and SMAD3 are also discussed in relation to abnormal protein degradation and the secondary immune response. It is clear that with increasing technology our understanding of IBD pathogenesis is deepening at the genomic level and that the use of early patient selection coupled with ongoing work on therapeutic targets will lead to improved disease‐modifying treatments in the near future. (Inflamm Bowel Dis 2011;)
3D Discrete Dislocation Dynamics simulations of the role of interfaces in confined materials - : application to electronic devices such as LEDs

Plastic deformation of classical crystalline materials is mostly dominated by dislocations and their mutual interactions. In nanocrystalline (nc) metals, different grain boundary mechanisms may exist in addition to the dislocation-based mechanisms. The dependency on, among other, the grain shape, grain orientation, initial dislocation density, grain boundary structure and external conditions will promote one or two deformation mechanisms over others. These dominant mechanisms dictate the overall response of nc metal. The influence of the microstructural features needs to be better understood individually and collectively. In the scope of the thesis, 3D discrete dislocation dynamics (DD) simulations were performed on three micron-sized single grains of same volume but differing in aspect ratios. Localization of plastic deformation was observed to decrease with increasing grain aspect ratio. Due to the enhanced cross-slip mechanism, grains with higher aspectratio exhibit a softer behavior. The anisotropic plastic response of elongated grains was quantified interms of the magnitude of back-stress on each slip system. Further, a polycrystalline version of dislocation dynamics code coupled with a finite elements was used, to study the mechanical behavior of free-standing palladium thin films with columnar grains. The initial dislocation density considered in the simulations is close to the one measured experimentally. DD simulations of a polycrystal with 12 equally sized hexagonal grains properly reproduce the strain hardening behavior. The increase in strength observed with decreasing film thickness was captured using a heterogenous grain size distribution of the polycrystal. The key element is that the probability of smaller grains with no inital dislocations is increasingwith decreasing thickness of the film. Difference in the back-stress contributions arising from the grain size distribution in the film was also quantified. Finally, by adapting Read’s model, the influence of a static, electrically-charged dislocation on electrical properties in semiconductors was studied.
Bifurcation lesions: no need to implant two stents when one is sufficient!

This editorial refers to ‘Coronary bifurcation lesions treated with simple or complex stenting: 5-year survival from patient-level pooled analysis of the Nordic Bifurcation study and the British Bifurcation Coronary Study’[†][1], by M.W. Behan et al . , on page 1923. The title of this Editorial seems an obvious statement; nevertheless, the question relating to a one- vs. two-stent strategy for bifurcation lesions has generated years of controversy and a large number of observational and randomized studies.1–6 At present, we can state that regarding whether to choose a one- or two-stent strategy, there are two types of bifurcation lesion. The first is lesions which require two stents as intention to treat. This type was not included in the randomized studies comparing the different strategies and it would … [1]: #fn-2
Rapid Detection of the hOGG1 Ser326Cys polymorphism Using LightCycler Technology

Human 8-oxoguanine DNA glycosylase 1 (hOGG1) plays an important role in the repair of 8-oxo-7, 8-dihydro-2′-deoxyguanosine (8-oxodGuo), one of the major constituents in DNA damage. A recent in vitro study showed that the hOGG1 326Cys polymorphism (rs1052133) exhibits reduced 8-oxodGuo repair activity. This study aimed to develop a LightCycler (LC) assay to analyze the C>G polymorphism (Ser326Cys) in exon 7 of the hOGG1 gene followed by validation of the method using DNA samples from 260 polycyclic aromatic hydrocarbons(PAH)-exposed workers with known 8-oxodGuo DNA-adduct values measured by HPLC. Twenty DNA samples were analyzed by a PCR-RFLP analysis with Fnu4H I to generate control DNA. LC melting curve analyses of the hOGG1 exon 7 PCR product were characteristic of the probes hybridized to the non-mutated Ser-type (CC) at 65°C, or to the Cys mutant (GG) at 59°C. The distribution in the population of PAH-exposed workers (N=260) was 58% (CC), 38%(CG), and 4% (GG). The minor G allele displayed a frequency of 23 %. The distribution of 8-oxodGuo adducts for the Ser326Cys variants of hOGG1 revealed geometric means (GM) of 5.83 (CC), 5.27 (CG), and 6.53 (GG) 8-oxodGuo adducts/106dGuo. Corresponding GM values of current smokers were 5.7 (CC), 5.6 (CG) and 7.0 (GG) 8-oxodGuo adducts/106 dGuo. The analysis of the Ser326Cys polymorphism in 260 DNA samples with this new LC assay revealed that this method is reliable for high throughput analysis of this key polymorphism in the hOGG1 gene.
Diversification and host switching in avian malaria parasites

The switching of parasitic organisms to novel hosts, in which they may cause the emergence of new diseases, is of great concern to human health and the management of wild and domesticated populations of animals. We used a phylogenetic approach to develop a better statistical assessment of host switching in a large sample of vector–borne malaria parasites of birds (Plasmodium and Haemoproteus) over their history of parasite-host relations. Even with sparse sampling, the number of parasite lineages was almost equal to the number of avian hosts. We found that strongly supported sister lineages of parasites, averaging 1.2% sequence divergence, exhibited highly significant host and geographical fidelity. Event–based matching of host and parasite phylogenetic trees revealed significant cospeciation. However, the accumulated effects of host switching and long distance dispersal cause these signals to disappear before 4% sequence divergence is achieved. Mitochondrial DNA nucleotide substitution appears to occur about three times faster in hosts than in parasites, contrary to findings on other parasite–host systems. Using this mutual calibration, the phylogenies of the parasites and their hosts appear to be similar in age, suggesting that avian malaria parasites diversified along with their modern avian hosts. Although host switching has been a prominent feature over the evolutionary history of avian malaria parasites, it is infrequent and unpredictable on time scales germane to public health and wildlife management.
Human leukocyte antigen (HLA)‐B*57:01‐restricted activation of drug‐specific T cells provides the immunological basis for flucloxacillin‐induced liver injury

The role of the adaptive immune system in adverse drug reactions that target the liver has not been defined. For flucloxacillin, a delay in the reaction onset and identification of human leukocyte antigen (HLA)‐B*57:01 as a susceptibility factor are indicative of an immune pathogenesis. Thus, we characterize flucloxacillin‐responsive CD4+ and CD8+ T cells from patients with liver injury and show that naive CD45RA+CD8+ T cells from volunteers expressing HLA‐B*57:01 are activated with flucloxacillin when dendritic cells present the drug antigen. T‐cell clones expressing CCR4 and CCR9 migrated toward CCL17 and CCL 25, and secreted interferon‐gamma (IFN‐γ), T helper (Th)2 cytokines, perforin, granzyme B, and FasL following drug stimulation. Flucloxacillin bound covalently to selective lysine residues on albumin in a time‐dependent manner and the level of binding correlated directly with the stimulation of clones. Activation of CD8+ clones with flucloxacillin was processing‐dependent and restricted by HLA‐B*57:01 and the closely related HLA‐B*58:01. Clones displayed additional reactivity against β‐lactam antibiotics including oxacillin, cloxacillin, and dicloxacillin, but not abacavir or nitroso sulfamethoxazole. Conclusion: This work defines the immune basis for flucloxacillin‐induced liver injury and links the genetic association to the iatrogenic disease. (HEPATOLOGY 2013;)
Influence of calcium hydroxide on the post-treatment pain in Endodontics: A systematic review

Introduction: Pain of endodontic origin has been a major concern to the patients and the clinicians for many years. Post-operative pain is associated with inflammation in the periradicular tissues caused by irritants egressing from root canal during treatment. It has been suggested that calcium hydroxide intra-canal medicament has pain-preventive properties because of its anti-microbial or tissue altering effects. Some dispute this and reasoned that calcium hydroxide may initiate or increase pain by inducing or increasing inflammation. Objective: To evaluate the effectiveness of calcium hydroxide in reducing the post-treatment pain when used as an intra-canal medicament Materials and Methods: The following databases were searched: PubMed CENTRAL (until July 2013), MEDLINE, and Cochrane Database of Systematic Reviews. Bibliographies of clinical studies and reviews identified in the electronic search were analyzed for studies published outside the electronically searched journals. The primary outcome measure was to evaluate the post-treatment pain reduction when calcium hydroxide is used as an intra-canal medicament in patients undergoing root canal therapy. Results: The reviews found some clinical evidence that calcium hydroxide is not very effective in reducing post-treatment pain when it is used alone, but its effectiveness can be increased when used in combination with other medicaments like chlorhexidine and camphorated monochlorophenol (CMCP). Conclusion: Even though calcium hydroxide is one of the most widely used intra-canal medicament due to its anti-microbial properties, there is no clear evidence of its effect on the post-treatment pain after the chemo-mechanical root canal preparation.
Bleaching agents with varying concentrations of carbamide and/or hydrogen peroxides: effect on dental microhardness and roughness.

PURPOSE To evaluate the effect of low and highly concentrated bleaching agents on microhardness and surface roughness of bovine enamel and root dentin. METHODS According to a randomized complete block design, 100 specimens of each substrate were assigned into five groups to be treated with bleaching agents containing carbamide peroxide (CP) at 10% (CP10); hydrogen peroxide (HP) at 7.5% (HP7.5) or 38% (HP38), or the combination of 18% of HP and 22% of CP (HP18/CP22), for 3 weeks. The control group was left untreated. Specimens were immersed in artificial saliva between bleaching treatments. Knoop surface microhardness (SMH) and average surface roughness (Ra) were measured at baseline and post-bleaching conditions. RESULTS For enamel, there were differences between bleaching treatments for both SMH and Ra measurements (p = 0.4009 and p = 0.7650, respectively). SMH significantly increased (p < 0.0001), whereas Ra decreased (p = 0.0207) from baseline to post-bleaching condition. For root dentin, the group treated with CP10 exhibited the significantly highest SMH value differing from those groups bleached with HP18/CP22, HP7.5, which did not differ from each other. Application of HP38 resulted in intermediate SMH values. No significant differences were found for Ra (p = 0.5975). Comparing the baseline and post-bleaching conditions, a decrease was observed in SMH (p < 0.0001) and an increase in Ra (p = 0.0063). CONCLUSION Bleaching agents with varying concentrations of CP and/or HP are capable of causing mineral loss in root dentin. Enamel does not perform in such bleaching agent-dependent fashion when one considers either hardness or surface roughness evaluations. CLINICAL SIGNIFICANCE Bleaching did not alter the enamel microhardness and surface roughness, but in root dentin, microhardness seems to be dependent on the bleaching agent used.