Miracle-dz/UniFAR-FTUs huggingface dataset:
A novel minimal exposure path problem in wireless sensor networks and its solution algorithm

The original minimal exposure path problem in wireless sensor networks did not consider path constraint conditions. To consider the actual demand, this article proposes a minimal exposure path problem that requires the passage of the path through the boundary of a certain region. In this situation, because a corresponding weighted graph model cannot be developed, the methods that are used to solve the original minimal exposure path problem (the grid method and the Voronoi diagram method) are ineffective. Thus, this article first converts the problem into an optimization problem with constraint conditions. Because of the difficulty in finding a solution due to the model’s high nonlinearity and high dimensional complexity, as well as the special characteristics of the problem, a hybrid genetic algorithm is proposed to find the solutions. This article also provides a proof for the convergence of the designed algorithm. A series of simulation experiments demonstrates that the designed optimization model with constraints and the hybrid genetic algorithm can effectively solve the proposed minimal exposure path problem.
Correlation between Age, Emergency Department Length of Stay and Hospital Admission Rate in Emergency Department Patients Aged ≥70 Years

Background: Interdisciplinary emergency departments (EDs) are confronted with trauma and nontrauma patients of any age group. Length of stay (LOS) and admission rates reflect both disease complexity and severity. Objective: To evaluate LOS and admission rates in different age groups according to traumatic and nontraumatic etiologies. Patients and Methods: During May 2011 a total of 4,653 adult patients (defined as ≥18 years old) seen in the ED of our municipal hospital were evaluated for their primary problem, Emergency Severity Index, LOS and admission rate. 1,841 trauma patients (mean age: 51.9 years; SD 22.5 years) and 2,812 nontrauma patients (mean age: 60.0 years; SD 20.4 years) were included. Results: Median LOS in the ED was 1:41 h (trauma) and 1:52 h (nontrauma). Trauma patients aged ≥70 years spent more time in the ED than nontrauma patients of this age group (patients aged ≥70 years median: 2:08 vs. 1:56 h; p < 0.0001). However, no significant difference was found in patients aged <70 years (1:33 vs. 1:48 h; p = 0.64). Comparing older with younger patients, median LOS within the ED was about 8 min longer in nontrauma patients aged ≥70 years (p = 0.22) and about 35 min longer in trauma patients aged ≥70 years (p < 0.00001). Conclusions: The correlation between age and LOS is stronger for trauma patients, which might indicate a special need for geriatric expertise in elderly trauma ED patients. Thus an interdisciplinary approach including surgical and geriatric expertise may be advantageous.
A rocky road.

And how this book will influence you to do better future? It will relate to how the readers will get the lessons that are coming. As known, commonly many people will believe that reading can be an entrance to enter the new perception. The perception will influence how you step you life. Even that is difficult enough; people with high sprit may not feel bored or give up realizing that concept. It's what a rocky road will give the thoughts for you.
Detrimental effects of melanocortin‐1 receptor (MC1R) variants on the clinical outcomes of BRAF V600 metastatic melanoma patients treated with BRAF inhibitors

Melanocortin‐1 receptor (MC1R) plays a key role in skin pigmentation, and its variants are linked with a higher melanoma risk. The influence of MC1R variants on the outcomes of patients with metastatic melanoma (MM) treated with BRAF inhibitors (BRAFi) is unknown. We studied the MC1R status in a cohort of 53 consecutive BRAF‐mutated patients with MM treated with BRAFi. We also evaluated the effect of vemurafenib in four V600BRAF melanoma cell lines with/without MC1R variants.
Migraine-Related Vertigo and Somatoform Vertigo Frequently Occur in Children and Are Often Associated

Abstract Migraine-related syndromes are a common cause of episodic vertigo and dizziness in children. Somatoform vertigo (SV) is an important cause of chronic dizziness, especially in adolescents. Our aim was to elucidate the comorbidity of migraine and SV. Three diagnostic groups were defined: migraine-related vertigo (MRV), SV, and combined migraine-related and SV (MSV). A retrospective analysis was performed on patient data (demographics, diagnosis, neuro-orthoptic and neurologic status, and results of vestibular and balance testing) from 168 patients who were presented to the German Center for Vertigo and Balance Disorders (IFB) over a 2.5-year period. Mean age of patients was 12 ± 4 years (range: 1.4 to 18 years). The most frequent diagnosis was MRV (28%), followed by MSV (19%) and SV (14%). MSV occurred most frequently in adolescent girls (25%). MRV was the most common cause of dizziness in our cohort. MSV ranked second overall but ranked first in adolescent girls, followed by isolated SV. SV was most prevalent in adolescent girls. MRV, MSV, and SV account for about 60% of diagnoses established in our tertiary referral center. Competent care of childhood migraine should include skill in detecting both the clinical symptoms of vertigo and overlapping somatoform symptoms.
The GIVE-2 Nancy Generation Systems NA and NM

This paper presents the two instruction generation systems submitted by the team TALARIS at INRIA-Nancy to the GIVE- 2 challenge 2010. The first system (NM) aims to provide high-level instructions by giving freedom to the user and relies on an extension of the Dale and Reiter's in- cremental algorithm to generate the refer- ring expressions. The second system (NA) uses a more constrained directive naviga- tional strategy and relies on Reference Do- main Theory (Denis, 2010) to generate a wide range of referring expressions in- cluding pronouns, ellipsis and alternative phrases. The results show that despite NA is more successful than NM, NM is consid- ered a bit more enjoyable by the subjective assessment.
Hybrid Recommender System based on Autoencoders

A standard model for Recommender Systems is the Matrix Completion setting: given partially known matrix of ratings given by users (rows) to items (columns), infer the unknown ratings. In the last decades, few attempts where done to handle that objective with Neural Networks, but recently an architecture based on Autoencoders proved to be a promising approach. In current paper, we enhanced that architecture (i) by using a loss function adapted to input data with missing values, and (ii) by incorporating side information. The experiments demonstrate that while side information only slightly improve the test error averaged on all users/items, it has more impact on cold users/items.
Simulating Intermediate Crack Debonding on RC Beams Strengthened with Hybrid Methods

The externally bonded (EB) and the near-surface mounted (NSM) are two well-known methods for strengthening reinforced concrete (RC) beams. Both methods are unfortunately prone to fail prematurely through debonding when the amount of strengthening reinforcement provided is high. In response to this, a hybrid method that combines the EB and NSM method was introduced. The method allows the amount of reinforcement needed for EB and NSM methods to be reduced; this, in theory, should lower the interfacial stresses, thus reducing the possibility of debonding failures. While debonding failure can be prevented, certain amounts of debonding would still occur through the interfacial crack (IC) debonding mechanism which can affect the strength and stiffness of hybrid strengthened beams even if it does not directly cause failure. This paper presents a method to simulate IC debonding of hybrid strengthened beams using the moment-rotation approach. The proposed method allows a better prediction of maximum load and stiffness of the beams. The method is also less dependent on empirical formulations compared to the commonly used moment-curvature approach; this allows the method to be applicable to all material and shape of hybrid strengthening reinforcement, assuming correct material models are used. The proposed method was then used to perform parametric studies; among the important findings is the length of IC debonding tend to increase when FRP sheet with higher elastic modulus is used, thus negating most of the benefit from the higher modulus.
Chemical Vapor Deposition Growth of Linked Carbon Monolayers with Acetylenic Scaffoldings on Silver Foil

Graphdiyne analogs, linked carbon monolayers with acetylenic scaffoldings, are fabricated by adopting low-temperature chemical vapor deposition which provides a route for the synthesis of two-dimensional carbon materials via molecular building blocks. The electrical conductivity of the as-grown films can reach up to 6.72 S cm-1 . Moreover, the films show potential as promising substrates for fluorescence suppressing and Raman advancement.
The Predictive Value of Depressive Symptoms for All-Cause Mortality: Findings From the PRIME Belfast Study Examining the Role of Inflammation and Cardiovascular Risk Markers

Objectives To improve understanding about the potential underlying biological mechanisms in the link between depression and all-cause mortality and to investigate the role that inflammatory and other cardiovascular risk factors may play in the relationship between depressive symptoms and mortality. Methods Depression and blood-based biological markers were assessed in the Belfast PRIME prospective cohort study (N = 2389 men, aged 50–59 years) in which participants were followed up for 18 years. Depression was measured using the 10-item Welsh Pure Depression Inventory. Inflammation markers (C-reactive protein [CRP], neopterin, interleukin [IL]-1 receptor antagonist [IL-1Ra], and IL-18) and cardiovascular-specific risk factors (N-terminal pro–b-type natriuretic peptide, midregion pro–atrial natriuretic peptide, midregion pro-adrenomedullin, C-terminal pro–endothelin-1 [CT-proET]) were obtained at baseline. We used Cox proportional hazards modeling to examine the association between depression and biological measures in relation to all-cause mortality and explore the mediating effects. Results During follow-up, 418 participants died. Higher levels of depressive symptoms were associated with higher levels of CRP, IL-1Ra, and CT-proET. After adjustment for socioeconomic and life-style risk factors, depressive symptoms were significantly associated with all-cause mortality (hazard ratio = 1.10 per scale unit, 95% confidence interval = 1.04–1.16). This association was partly explained by CRP (7.3%) suggesting a minimal mediation effect. IL-1Ra, N-terminal pro–b-type natriuretic peptide, midregion pro–atrial natriuretic peptide, midregion pro-adrenomedullin, and CT-proET contributed marginally to the association between depression and subsequent mortality. Conclusions Inflammatory and cardiovascular risk markers are associated with depression and with increased mortality. However, depression and biological measures show additive effects rather than a pattern of meditation of biological factors in the association between depression and mortality.
Self-motion perception in the elderly

Self-motion through space generates a visual pattern called optic flow. It can be used to determine one's direction of self-motion (heading). Previous studies have already shown that this perceptual ability, which is of critical importance during everyday life, changes with age. In most of these studies subjects were asked to judge whether they appeared to be heading to the left or right of a target. Thresholds were found to increase continuously with age. In our current study, we were interested in absolute rather than relative heading judgments and in the question about a potential neural correlate of an age-related deterioration of heading perception. Two groups, older test subjects and younger controls, were shown optic flow stimuli in a virtual-reality setup. Visual stimuli simulated self-motion through a 3-D cloud of dots and subjects had to indicate their perceived heading direction after each trial. In different subsets of experiments we varied individually relevant stimulus parameters: presentation time, number of dots in the display, stereoscopic vs. non-stereoscopic stimulation, and motion coherence. We found decrements in heading performance with age for each stimulus parameter. In a final step we aimed to determine a putative neural basis of this behavioral decline. To this end we modified a neural network model which previously has proven to be capable of reproduce and predict certain aspects of heading perception. We show that the observed data can be modeled by implementing an age related neuronal cell loss in this neural network. We conclude that a continuous decline of certain aspects of motion perception, among them heading, might be based on an age-related progressive loss of groups of neurons being activated by visual motion.
Earthquake source scaling and self-similarity estimation by stacking P and S spectra

[1] We study the scaling relationships of source parameters and the self-similarity of earthquake spectra by analyzing a cluster of over 400 small earthquakes (ML = 0.5 to 3.4) recorded by the Anza seismic network in southern California. We compute P, S, and preevent noise spectra from each seismogram using a multitaper technique and approximate source and receiver terms by iteratively stacking the spectra. To estimate scaling relationships, we average the spectra in size bins based on their relative moment. We correct for attenuation by using the smallest moment bin as an empirical Green's function (EGF) for the stacked spectra in the larger moment bins. The shapes of the log spectra agree within their estimated uncertainties after shifting along the ω−3 line expected for self-similarity of the source spectra. We also estimate corner frequencies and radiated energy from the relative source spectra using a simple source model. The ratio between radiated seismic energy and seismic moment (proportional to apparent stress) is nearly constant with increasing moment over the magnitude range of our EGF-corrected data (ML = 1.8 to 3.4). Corner frequencies vary inversely as the cube root of moment, as expected from the observed self-similarity in the spectra. The ratio between P and S corner frequencies is observed to be 1.6 ± 0.2. We obtain values for absolute moment and energy by calibrating our results to local magnitudes for these earthquakes. This yields a S to P energy ratio of 9 ± 1.5 and a value of apparent stress of about 1 MPa.
Excluding venous thromboembolism using point of care D-dimer tests in outpatients: a diagnostic meta-analysis

Objective To review the evidence on the diagnostic accuracy of the currently available point of care D-dimer tests for excluding venous thromboembolism. Design Systematic review of research on the accuracy of point of care D-dimer tests, using bivariate regression to examine sources of variation and to estimate sensitivity and specificity. Data sources Studies on the diagnostic accuracy of point of care D-dimer tests published between January 1995 and September 2008 and available in either Medline or Embase. Review methods The analysis included studies that compared point of care D-dimer tests with predefined reference criteria for venous thromboembolism, enrolled consecutive outpatients, and allowed for construction of a 2×2 table. Results 23 studies (total number of patients 13 959, range in mean age 38-65 years, range of venous thromboembolism prevalence 4-51%) were included in the meta-analysis. The studies reported two qualitative point of care D-dimer tests (SimpliRED D-dimer (n=12) and Clearview Simplify D-dimer (n=7)) and two quantitative point of care D-dimer tests (Cardiac D-dimer (n=4) and Triage D-dimer (n=2)). Overall sensitivity ranged from 0.85 (95% confidence interval 0.78 to 0.90) to 0.96 (0.91 to 0.98) and overall specificity from 0.48 (0.33 to 0.62) to 0.74 (0.69 to 0.78). The two quantitative tests Cardiac D-dimer and Triage D-dimer scored most favourably. Conclusions In outpatients suspected of venous thromboembolism, point of care D-dimer tests can contribute important information and guide patient management, notably in low risk patients (that is, those patients with a low score on a clinical decision rule).
Toxicological Assessment of the Cochleate Derived from Neisseria meningitidis Proteoliposome in Sprague Dawley Rats

Background: The AFCo1 cochleate is a potential novel adjuvant derived from Neisseria meningitidis B proteoliposome. Aim: The aim was to assessing the safety of AFCo1 by single and repeated doses in Sprague Dawley rats. Materials and Methods: Rats were grouped for treatment with AFCo1, placebo formulation or control. The first study was a single intranasal dose of 100 μl and monitoring body weight, water, and food intakes as well as clinical symptoms. Fourteen days later the rats were killed and anatomopathological studies were conducted. In a second study, four similar doses of the test substance were instilled every 5 days. Clinical observations were carried out as for the single dose study and a number of rats from each group were killed 3 and 14 days after the last dose in order to conduct hematological, hemochemical, and anatomopathological studies. Results: No variable showed differences of toxicological relevance; the histological changes found were mild and similarly frequently in the three groups. According to the irritability index calculated form histology of the nasal region, AFCo1 was also classified as nonirritating. Conclusion: AFCo1 is potentially safe for human use by nasal route as evidenced by the absence of local and systemic signs of toxicity in Sprague Dawley rats.
A Breastfeeding Quality Improvement Project in Rural Primary Care

Background: Breastfeeding is the gold standard nutrition for infants, and more than three-fourths of US mother–infant couplets initiate breastfeeding at birth. However, breastfeeding rates plummet after hospital discharge, when mother–infant couplets enter primary care. This quality improvement project examined the effect of a primary care intervention on breastfeeding rates from the newborn visit through the 4-month visit. Objective: The overall aim of this evidence-based quality improvement project was to increase breastfeeding rates by refining the care provided to a diverse patient population with historically low breastfeeding rates. Methods: Two independent groups of mother–infant couplets, a pre-implementation (N = 43) and a post-implementation (N = 45), were longitudinally evaluated on breastfeeding rates at the newborn, 1-month, 2-month, and 4-month well-child visits for exclusive, partial, and any breastfeeding rates. Relationships for the 2 groups were compared using 2-sample t tests, chi-square, and Fisher exact tests. Results: Post-implementation rates for any breastfeeding progressively increased at each timepoint. Exclusive breastfeeding increased 40.98% at the 1-month visit, 27.4% at the 2-month visit, and 139% at the 4-month visit. Conclusion: The implementation of an evidence-based breastfeeding-friendly office protocol in a rural low breastfeeding rate primary care setting was associated with increased breastfeeding rates.
Hemodynamic predictors of survival in scleroderma-related pulmonary arterial hypertension.

RATIONALE Pulmonary arterial hypertension (PAH) related to systemic sclerosis (SSc) has a poorer prognosis compared with other forms of PAH for reasons that remain unexplained. OBJECTIVES To identify risk factors of mortality in a well-characterized cohort of patients with PAH related to systemic sclerosis (SSc-PAH). METHODS Seventy-six consecutive patients with SSc (64 women and 12 men; mean age 61 +/- 11 yr) were diagnosed with PAH by heart catheterization in a single center, starting in January 2000, and followed over time. Kaplan-Meier estimates were calculated and mortality risk factors were analyzed. MEASUREMENTS AND MAIN RESULTS Forty (53%) patients were in World Health Organization functional class III or IV. Mean pulmonary artery pressure was 41 +/- 11 mm Hg, pulmonary vascular resistance (PVR) was 8.6 +/- 5.6 Wood units, and cardiac index was 2.4 +/- 0.7 L/min/m(2). Median follow-up time was 36 months, with 42 deaths observed. Survival estimates were 85%, 72%, 67%, 50%, and 36% at 1, 2, 3, 4, and 5 years, respectively. Multivariate analysis identified PVR (hazard ratio [HR], 1.10; 95% confidence interval [CI], 1.03-1.18; P < 0.01), stroke volume index (HR, 0.94; 95% CI, 0.89-0.99; P = 0.02), and pulmonary arterial capacitance (HR, 0.43; 95% CI, 0.20-0.91; P = 0.03) as strong predictors of survival. An estimated glomerular filtration rate less than 60 ml/min/1.73 m(2) portended a threefold risk of mortality. CONCLUSIONS Our results suggest that specific components of right ventricular dysfunction and renal impairment contribute to increased mortality in SSc-PAH. Understanding the mechanisms of right ventricular dysfunction in response to increased afterload should lead to improved targeted therapy in these patients.
Usage analysis in e-learning system for healthcare

Education and possible further studies have become a rather demanding investment. At the time of imperfect technology, i.e. technology of the previous period, it was a very difficult and doubtable task. But, is an ordinary use of new technologies a formula for the solution? We shall try to adequately answer this question. In our contribution we shall introduce educational activities (e-courses) based on cooperation and experimentation within the combined form of education. All presented information was implemented and verified in the combined forms of education. The authors present a detailed analysis of the user log-on data, on which we can better understand the behavior of the student in an electronic learning environment.
Advancing Workplace Health Protection and Promotion for an Aging Workforce

Objective: To explore issues related to the aging workforce, including barriers to integrating health protection and promotion programs, and provide recommendations for best practices to maximize contributions by aging workers. Methods: Workgroups reviewed literature and case studies to develop consensus statements and recommendations for a national approach to issues related to older workers. Results: Consensus statements and actions steps were identified for each of the Summit goals and call-to-action statements were developed. Conclusions: A national dialogue to build awareness of integrated health protection and promotion for the aging workforce is needed. Workers will benefit from improved health and performance; employers will realize a more engaged and productive workforce; and the nation will gain a vital, competitive workforce.