Miracle-dz/UniFAR-FTUs huggingface dataset:
Stem Cells as a Potential Adjunctive Therapy in Aneurysmal Subarachnoid Hemorrhage.

BACKGROUND Despite advances in the management of subarachnoid hemorrhage, a considerable proportion of patients are still left with severe and disabling long-term consequences. Unfortunately, there are limited therapeutic options to counteract the sequelae following the initial insult. The role of stem cells has been studied in the treatment of various diseases. The goal of this study was to provide a literature review regarding the potential advantages of stem-cell therapy to counteract or minimize the sequelae of aneurysmal subarachnoid hemorrhage. METHODS PubMed, Google Scholar, and ClinicalTrials.gov searches were conducted to incorporate pertinent studies that discussed stem cell use in the management of subarachnoid hemorrhage. Included articles were subjected to data extraction for the synthesis of the efficacy of stem-cell therapy. RESULTS Four preclinical studies with 181 animal model subjects (44 mice, 137 rats) were incorporated in our review. Endovascular punctures (65%) and blood injections in subarachnoid spaces (17%) were used to induce hemorrhage models. Stem cells were administered intravenously (3.0 × 10(6) cells) or intranasally (1.5 × 10(6) cells). According to literature, mesenchymal cell therapy significantly (p<0.05) induces stem-cell migration to lesion sites, decreases associated neural apoptosis and inflammation, improves ultrastructural integrity of cerebral tissue, and aids in improving sensorimotor function post subarachnoid hemorrhage. CONCLUSION Stem cells, particularly mesenchymal stem cells, have shown promising cellular, morphological, and functional benefits in animal models suffering from induced subarachnoid hemorrhages. However, further studies are warranted to elucidate the full effects of stem-cell therapy for aneurysmal subarachnoid hemorrhage.
Adversarial Label Flips Attack on Support Vector Machines

To develop a robust classification algorithm in the adversarial setting, it is important to understand the adversary's strategy. We address the problem of label flips attack where an adversary contaminates the training set through flipping labels. By analyzing the objective of the adversary, we formulate an optimization framework for finding the label flips that maximize the classification error. An algorithm for attacking support vector machines is derived. Experiments demonstrate that the accuracy of classifiers is significantly degraded under the attack.
The Autosomal Dominant Hypophosphatemic Rickets R176Q Mutation in Fibroblast Growth Factor 23 Resists Proteolytic Cleavage and Enhances in Vivo Biological Potency*

Missense mutations in fibroblast growth factor 23 (FGF23) are the cause of autosomal dominant hypophosphatemic rickets (ADHR). The mutations (R176Q, R179W, and R179Q) replace Arg residues within a subtilisin-like proprotein convertase (SPC) cleavage site (RXXR motif), leading to protease resistance of FGF23. The goals of this study were to examine in vivo the biological potency of the R176Q mutant FGF23 form and to characterize alterations in homeostatic mechanisms that give rise to the phenotypic presentation of this disorder. For this, wild type and R176Q mutant FGF23 were overexpressed in the intact animals using a tumor-bearing nude mouse system. At comparable circulating levels, the mutant form was more potent in inducing hypophosphatemia, in decreasing circulating concentrations of 1,25-dihydroxyvitamin D3(1,25(OH)2D3), and in causing rickets and osteomalacia in these animals compared with wild type FGF23. Parameters of calcium homeostasis were also altered, leading to secondary hyperparathyroidism and parathyroid gland hyperplasia. However, the raised circulating levels of parathyroid hormone were ineffective in normalizing the reduced 1,25(OH)2D3 levels by increasing renal expression of 25(OH)D3-1α-hydroxylase (Cyp40) to promote its synthesis and by decreasing that of 25(OH)D3-24-hydroxylase (Cyp24) to prevent its catabolism. The findings provide direct in vivo evidence that missense mutations from ADHR kindreds are gain-of-function mutations that retain and increase the protein's biological potency. Moreover, for the first time, they define a potential role for FGF23 in dissociating parathyroid hormone actions on mineral fluxes and on vitamin D metabolism at the level of the kidney.
MRI features of pleural endometriosis after catamenial haemothorax

A 43-year-old multiparous woman with a history of pelvic endometriosis and myocardial infarction presented with acute onset of right hemithorax pain and dyspnoea coinciding with dysmenorrhoeic menstruation. A chest CT confirmed the presence of a right hydropneumothorax which was drained. A video-assisted thoracoscopy was unremarkable but at a subsequent menses, an MRI chest demonstrated a lesion in the right costophrenic angle. The patient underwent a hysterectomy and oophorectomy for treatment of endometriosis. Six months later, she was free of thoracic symptoms and a repeat MRI scan showed resolution of the right pleural abnormality.
Revealing the competition between peeled ssDNA, melting bubbles, and S-DNA during DNA overstretching by single-molecule calorimetry

Double-stranded DNA (dsDNA) unconstrained by torsion undergoes an overstretching transition at about 65 pN, elongating the DNA to about 1.7-fold. Three possible structural transitions have been debated for the nature of DNA overstretching: (i) “peeling” apart of dsDNA to produce a peeled ssDNA strand under tension while the other strand coils, (ii) “inside-strand separation” of dsDNA to two parallel ssDNA strands that share tension (melting bubbles), and (iii) “B-to-S” transition to a novel dsDNA, termed S-DNA. Here we overstretched an end-opened DNA (with one open end to allow peeling) and an end-closed (i.e., both ends of the linear DNA are covalently closed to prohibit peeling) and torsion-unconstrained DNA. We report that all three structural transitions exist depending on experimental conditions. For the end-opened DNA, the peeling transition and the B-to-S transition were observed; for the end-closed DNA, the inside-strand separation and the B-to-S transition were observed. The peeling transition and the inside-strand separation are hysteretic and have an entropy change of approximately 17 cal/(K⋅mol), whereas the B-to-S transition is nonhysteretic and has an entropy change of approximately −2 cal/(K⋅mol). The force-extension curves of peeled ssDNA, melting bubbles, and S-DNA were characterized by experiments. Our results provide experimental evidence for the formation of DNA melting bubbles driven by high tension and prove the existence of nonmelted S-DNA. Our findings afford a full understanding of three possible force-driven structural transitions of torsion-unconstrained DNA and the resulting three overstretched DNA structures.
Removal of Heavy Metals from Contamined Aquifers by Vegetable Fibers. Comparisons among Cabuya Fibers, Broom Fibers and ZVI

The growing contamination of groundwater requires increasingly remediation. Among the different reclamation techniques of contaminated aquifers, recourse is frequently made to permeable reactive barriers (PRB). To build such barriers Zero Valent Iron (ZVI) is commonly used, which shows a good reactivity towards the most part of the heavy metals. However, owing to economic reasons, and to some problems that this substance produces, reactive substances usable in alternative to zero valent iron are constantly being researched. The present study takes into account the fibers of a vegetable substance, the cabuya, investigating its capacity to retain heavy metals. Specifically, among these, Copper (Cu), Zinc (Zn), Lead (Pb) and Cadmium (Cd) were considered. The capacity of the fibers of cabuya to absorb heavy metals was verified in the laboratory, at first by batch tests and later by appropriate column tests. The same tests were carried out using also Zero Valent Iron. The results obtained for the cabuya vegetable fibers, showed a very high adsorption capacity of heavy metals and resulted very comparable to that of ZVI, without, however, showing the negative aspects of the latter. Some comparisons were also carried out with broom fibers, investigated in a previous study.
Refractive errors among children, adolescents and adults attending eye clinics in Mexico.

AIM To assess the proportion of refractive errors in the Mexican population that visited primary care optometry clinics in fourteen states of Mexico. METHODS Refractive data from 676 856 patients aged 6 to 90y were collected from optometry clinics in fourteen states of Mexico between 2014 and 2015. The refractive errors were classified by the spherical equivalent (SE), as follows: sphere+½ cylinder. Myopia (SE>-0.50 D), hyperopia (SE>+0.50 D), emmetropia (-0.50≤SE≤+0.50), and astigmatism alone (cylinder≥-0.25 D). A negative cylinder was selected as a notation. RESULTS The proportion (95% confidence interval) among all of the subjects was hyperopia 21.0% (20.9-21.0), emmetropia 40.7% (40.5-40.8), myopia 24.8% (24.7-24.9) and astigmatism alone 13.5% (13.4-13.5). Myopia was the most common refractive error and frequency seemed to increase among the young population (10 to 29 years old), however, hyperopia increased among the aging population (40 to 79 years old), and astigmatism alone showed a decreasing trend with age (6 to 90y; from 19.7% to 10.8%). There was a relationship between age and all refractive errors (approximately 60%, aged 50 and older). The proportion of any clinically important refractive error was higher in males (61.2%) than in females (58.3%; P<0.0001). From fourteen states that collected information, the proportion of refractive error showed variability in different geographical areas of Mexico. CONCLUSION Myopia is the most common refractive error in the population studied. This study provides the first data on refractive error in Mexico. Further programs and studies must be developed to address the refractive errors needs of the Mexican population.
NTOMOLOGY : A S URVEY

Entomology has been deeply rooted in various cultures since prehistoric times for the purpose of agriculture. Nowadays, many scientists are interested in the field of biodiversity in order to maintain the diversity of species within our ecosystem. Out of 1.3 million known species on this earth, insects account for more than two thirds of these known species. Since 400 million years ago, there have been various kinds of interactions between humans and insects. There have been several attempts to create a method to perform insect identification accurately. Great knowledge and experience on entomology are required for accurate insect identification. Automation of insect identification is required because there is a shortage of skilled entomologists. This paper provides a review of the past literature in vision-based insect recognition and classifications. Over the past decades, automatic insect recognition and classification has been given extra attention especially in term of crop pest and disease control. This paper details advances in insect recognition, discussing representative works from different types of method and classifiers algorithm. Among the method used in the previous research includes color histogram, edge detection and feature extraction (SIFT vector). We provides discussion on the state-of-the-art and provides perspective on future research direction in insect recognition and classification problem.
Chaperone-Usher Pili Loci of Colonization Factor-Negative Human Enterotoxigenic Escherichia coli

Enterotoxigenic Escherichia coli (ETEC) is one of the most common causes of diarrhea worldwide. Among the 25 different ETEC adhesins, 22 are known as “colonization factors” (CFs), of which 17 are assembled by the chaperone-usher (CU) mechanism. Currently, there is no preventive therapy against ETEC, and CFs have been proposed as components for vaccine development. However, studies of diarrhea-causing ETEC strains worldwide indicate that between 15 and 50% of these are negative for known CFs, hindering the selection of the most widespread structures and suggesting that unknown adhesins remain to be identified. Here, we report the result of a comprehensive analysis of 35 draft genomes of ETEC strains which do not carry known adhesin genes; our goal was to find new CU pili loci. The phylogenetic profiles and serogroups of these strains were highly diverse, a majority of which produced only the heat-labile toxin. We identified 10 pili loci belonging to CU families β (1 locus), γ2 (7 loci), κ (1 locus), and π (1 locus), all of which contained the required number of open reading frames (ORFs) to encode functional structures. Three loci were variants of previously-known clusters, three had been only-partially described, and four are novel loci. Intra-loci genetic variability identified would allow the synthesis of up to 14 different structures. Clusters of putative γ2-CU pili were most common (23 strains), followed by putative β-CU pili (12 strains), which have not yet been fully characterized. Overall, our findings significantly increase the number of ETEC adhesion genes associated with human infections.
Comparison of responses to tensile and compressive stimuli in C-mechanosensitive nociceptors in rat hairy skin

Mechanosensitive nociceptors with unmyelinated axons (C-fibers) were studied in a preparation of isolated skin and nerve from rat. Afferent discharges were recorded while the skin was mechanically stimulated using quantitative stretch (tension) and indentation (compression). The apparatus allowed for generating stimuli of equal magnitudes in both tension and compression. Stimulus-response functions were obtained for individual afferents relating discharge rate to tensile stress or compressive stress. A response threshold and maximal slope were obtained from each function. Thresholds did not differ significantly for compression and tension nor did the maximal slopes. We conclude that C-nociceptors are equally sensitive to tensile and compressive stress.
Evidence-based software engineering

Our objective is to describe how software engineering might benefit from an evidence-based approach and to identify the potential difficulties associated with the approach. We compared the organisation and technical infrastructure supporting evidence-based medicine (EBM) with the situation in software engineering. We considered the impact that factors peculiar to software engineering (i.e. the skill factor and the lifecycle factor) would have on our ability to practice evidence-based software engineering (EBSE). EBSE promises a number of benefits by encouraging integration of research results with a view to supporting the needs of many different stakeholder groups. However, we do not currently have the infrastructure needed for widespread adoption of EBSE. The skill factor means software engineering experiments are vulnerable to subject and experimenter bias. The lifecycle factor means it is difficult to determine how technologies will behave once deployed. Software engineering would benefit from adopting what it can of the evidence approach provided that it deals with the specific problems that arise from the nature of software engineering.
Gender Equality and Economic Development: The Role for Information and Communication Technologies

The author focuses on the role that information and communication technologies (ICTs) can play in improving gender equality, so as to enhance long-term economic growth. Employing OLS and IV panel regressions with country fixed-effects, he shows that increases in the level of ICT infrastructure tend to improve gender equality in education and employment. In addition, the author shows that education among the general population is important for improving gender equality. The results provide evidence indicating that gender equality in education is an important contributor to gender equality in employment. Lastly, the results show that economic development tends to lead to some improvements in gender equality in the labor market. Hence, the use of ICTs to improve gender equality in education and employment may initiate a continuous cycle of positive reinforcing feedback effects between gender equality in employment and economic development, leading to further improvements in both.
nutrition and Performance Ergogenic Aids to Performance in the Race Horse : Nutrients or Drugs 1

Since the domestication of the horse and its use in various types of athletic competition, its diet has developed from that associated with grazing to feeding of additional energy in the form of grains up to the present situation when numerous supplements are fed in hopes of enhancing performance. Many if not all of these may be considered as ergogenic aids, and under the rules of racing in many countries should be con sidered as a prohibited substance. Until recently, a blind eye has been turned to whether the rules should be enforced against many nutritional supplements, for ex ample, vitamins and amino acids, especially when given in amounts vastly in excess of normal requirements. However, although arguably a nutrient, large doses of sodium bicarbonate and possibly other compounds with the potential of improving buffering capacity have been used extensively, and rules and detection methods have been introduced to curtail this. This paper reviews the nutritional supplements currently in use and discusses whether the singling out of alkalinizing agents as an enforceable prohibited substance is justified, whereas other substances such as fats can be supplemented in high amounts. J. Nutr. 124: 2730S-2735S, 1994.
A review of stimulant drug research with hyperactive children.

SUMMARY A number of studies using stimulant drugs with hyperactive children are reviewed. Results indicated that most children are judged as improved on the drugs while a small percentage are not. Although most side effects are transitory, suppressed weight and height gain may remain problematic throughout treatment. The drugs appear to energize the central nervous system of these children while increasing their ability to concentrate without responding impulsively. Changes in other abilities are occasionally observed but appear to result from improvement in attentional processes. In contrast, follow-up studies find the long-term psycho-social adjustment of these children to be essentially unaffected by stimulant drug treatment.
Reevaluation by high-performance liquid chromatography: clinical significance of microalbuminuria in individuals at high risk of cardiovascular disease in the Heart Outcomes Prevention Evaluation (HOPE) Study.

BACKGROUND In the Heart Outcomes Prevention Evaluation Study, microalbumin and albumin levels measured by using radioimmunoassay (RIA) and less than the microalbuminuria threshold in baseline urine samples were associated independently with cardiovascular (CV) events. Conventional immunoassays may underestimate albuminuria by not detecting a mildly denatured unfragmented form of albumin, immunounreactive to conventional antibodies. METHODS Microalbuminuria was reanalyzed in baseline samples stored at -70 degrees C for 5,358 North American participants, 1,992 with diabetes mellitus, by using a high-performance liquid chromatography (HPLC) system that also detects immunochemically nonreactive urinary albumin. RESULTS The HPLC compared with RIA method identified microalbuminuria in 1,585 versus 719 participants, 809 versus 423 patients with diabetes, by using a conventionally accepted albumin-creatinine ratio (ACR) of 29 mg/g or greater (>or=3 mg/mmol) as a cutoff value. HPLC-detected microalbuminuria increased risk for the primary outcome (a composite of myocardial infarction, stroke, and CV death); unadjusted hazard ratio, 1.85 (95% confidence interval, 1.57 to 2.19). Receiver operating characteristic analysis did not differentiate between HPLC- and RIA-detected microalbuminuria as predictors of CV outcomes. CONCLUSION The prevalence of microalbuminuria is 2 to 3 times greater with HPLC than RIA using an ACR of 29 mg/g or greater (>or=3 mg/mmol). The optimal cutoff value for detecting CV risk in the entire study population by means of RIA was 9 mg/g (0.9 mg/mmol), and with HPLC, 32 mg/g (3.4 mg/mmol). Results from this study also show different ACR cutoff values for individuals with diabetes: RIA, 13 mg/g or greater (>or=1.4 mg/mmol); HPLC, 44 mg/g or greater (>or=5.2 mg/mmol) and without diabetes: RIA, 7 mg/g or greater (>or=0.7 mg/mmol); HPLC, 29 mg/g or greater (>or=3/1 mg/mmol). Results highlight the importance of method-dependent cutoff values in the prediction of CV events.
Cytomegalovirus associated hemophagocytic lymphohistiocytosis in patients suffering from Crohn's disease treated by azathioprine: a series of four cases.

HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés. Cytomegalovirus associated hemophagocytic lymphohistiocytosis in patients suffering from crohn’s disease treated by azathioprine: A series of four cases Yohan N’guyen, Sonia Baumard, Jean Salmon, Louis Lemoine, Nicolas Lévêque, Amélie Servettaz, Roland Jaussaud, Christophe Strady, Laurent Andreoletti
Assembly and turnover of neurofilaments in growing axonal neurites

ABSTRACT Neurofilaments (NFs) are thought to provide stability to the axon. We examined NF dynamics within axonal neurites of NB2a/d1 neuroblastoma by transient transfection with green fluorescent protein-tagged NF-heavy (GFP-H) under the control of a tetracycline-inducible promoter. Immunofluorescent and biochemical analyses demonstrated that GFP-H expressed early during neurite outgrowth associated with a population of centrally-situated, highly-phosphorylated crosslinked NFs along the length of axonal neurites (‘bundled NFs’). By contrast, GFP-H expressed after considerable neurite outgrowth displayed markedly reduced association with bundled NFs and was instead more evenly distributed throughout the axon. This differential localization was maintained for up to 2 weeks in culture. Once considerable neurite outgrowth had progressed, GFP that had previously associated with the NF bundle during early expression was irreversibly depleted by photobleaching. Cessation of expression allowed monitoring of NF turnover. GFP-H associated bundled NFs underwent slower decay than GFP-H associated with surrounding, less-phosphorylated NFs. Notably, GFP associated with bundled NFs underwent similar decay rates within the core and edges of this bundle. These results are consistent with previous demonstration of a resident NF population within axonal neurites, but suggest that this population is more dynamic than previously considered. Summary: Immunofluorescent and radiolabel analyses demonstrate that neurofilaments establish a resident population within growing axonal neurites that undergoes exchange with a surrounding, transporting pool.