Miracle-dz/UniFAR-FTUs huggingface dataset:
Biological Roles of Interferon Tau (IFNT) and Type I IFN Receptors in Elongation of the Ovine Conceptus1

ABSTRACT Interferon tau (IFNT) is produced by the elongating conceptus in ruminants and is the maternal recognition of the pregnancy signal. Available evidence supports the idea that IFNT acts in a paracrine and autocrine manner to modulate expression of genes in the endometrium and trophectoderm, respectively, which promote conceptus elongation. The actions of IFNT are mediated by the interferon (alpha and beta) receptor (IFNAR), which consists of two subunits, IFNAR1 and IFNAR2. To test the hypothesis that IFNT and its receptor have biological roles in conceptus elongation, an in vivo loss-of-function study was conducted by inhibiting IFNT or IFNAR1/2 mRNA translation in the trophectoderm of the ovine conceptus using morpholino antisense oligonucleotides (MAO) delivered via osmotic pumps from Days 8 to 14 postmating. Elongating, filamentous type conceptuses were recovered from Day 14 ewes receiving a control morpholino or IFNAR MAOs. In contrast, severely growth-retarded and malformed conceptuses were recovered from IFNT MAO-infused ewes. Those conceptuses contained abnormal trophectoderm cells that were apoptotic based on terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling analyses. IFNT concentrations were reduced in the uterine lumen of IFNT MAO-infused ewes as was the expression of classical Type I IFN-stimulated genes in the endometrium. IFNT concentrations were also lower in the uterine lumen of IFNAR1/2 MAO-infused ewes. These studies provide in vivo evidence that IFNT is a critical regulator of conceptus elongation and that its embryotrophic actions are primarily mediated by paracrine effects on the endometrium.
The CFTR gene mild variants poly‐T, TG repeats and M470V detection in Indian men with congenital bilateral absence of vas deferens

The aim of the study was to detect the frequency of the CFTR gene variants poly‐T, TG repeats and c.1408A>G p.Met470Val (M470V) in Indian men with congenital bilateral absence of the vas deferens (CBAVD). Men diagnosed with CBAVD (n = 76), their female partners (n = 76) and healthy men from general population (n = 50) were recruited. Genomic DNA was isolated and the polymorphic regions of IVS9‐ c.1210‐12T [5] and M470V were amplified using specific primers followed by Sanger's DNA sequencing. A statistically significant increase in the frequency of heterozygous IVS9‐ c.1210‐12T [5] (39.4%) was observed in CBAVD men as compared to controls (14%). The allelic distribution of c.1210‐12T [5], c.1210‐12T [7] and c.1210‐12T [9] in CBAVD men was 21%, 64.4% and 13% and that in healthy controls was 7%, 73% and 20% respectively. Longest TG repeat c.1210‐34TG [13] was found in association with c.1210‐12T [5] with an allelic frequency of 5.9% in CBAVD men. We found a significant association of c.1210‐34TG [12]/c.1210‐34TG [13] ‐ c.1210‐12[5] –V470 allele in CBAVD men. Twelve female partners harboured a heterozygous c.1210‐12T [5] allele. The study emphasises the need to screen both partners for the polymorphisms M470V, poly‐T, TG tract repeats in addition to population‐specific known CFTR gene mutations.
Computing Equilibria in Multiplayer Stochastic Games of Imperfect Information

Computing a Nash equilibrium in multiplayer stochastic games is a notoriously difficult problem. Prior algorithms have been proven to converge in extremely limited settings and have only been tested on small problems. In contrast, we recently presented an algorithm for computing approximate jam/fold equilibrium strategies in a three-player nolimit Texas hold'em tournament--a very large real-world stochastic game of imperfect information [5]. In this paper we show that it is possible for that algorithm to converge to a non-equilibrium strategy profile. However, we develop an ex post procedure that determines exactly how much each player can gain by deviating from his strategy and confirm that the strategies computed in that paper actually do constitute an e-equilibrium for a very small e (0.5% of the tournament entry fee). Next, we develop several new algorithms for computing a Nash equilibrium in multiplayer stochastic games (with perfect or imperfect information) which can provably never converge to a non-equilibrium. Experiments show that one of these algorithms outperforms the original algorithm on the same poker tournament. In short, we present the first algorithms for provably computing an e-equilibrium of a large stochastic game for small e. Finally, we present an efficient algorithm that minimizes external regret in both the perfect and imperfect information cases.
Semiconducting Polyfluorenes—Towards Reliable Structure–Property Relationships

Alkylsabstituted polyfluorenes have emerged as a very attractive class of conju gated polymers, especially for display applications, owing to their pure blue and efficient electroluminescence coupled with a high charge-carrier mobility and good processability. The availability of specific and highly regroselective coupling reactions provides a rich variety of taifored polyfluorene-type paly mers and copolymers. The focus of this review, therefore, is on reliable structure-property relationships regarding (i) the interplay of substitution pattern, solid state morphology, and optical/electronic properties, and (ii) the key role of degradation-induced keto defect sites in fluorerse-type polymers, and strategies for obtaining defect-free polyfluorenes.
Timely Coordination in a Multi-Agent System

In a distributed algorithm, multiple processes, or agents, work toward a common goal. More often than not, the actions of some agents are dependent on the previous execution (if not also on the outcome) of the actions of other agents. The resulting interdependencies between the timings of the actions of the various agents give rise to the study of methods for timely coordination of these actions. In this work, we formulate and mathematically analyze "Timely-Coordinated Response" - a novel multi-agent coordination problem in which the time difference between each pair of actions may be constrained by upper and/or lower bounds. This problem generalizes coordination problems previously studied by Halpern and Moses and by Ben-Zvi and Moses. We optimally solve timely-coordinated response in two ways: using a generalization of the fixed-point approach of Halpern and Moses, and using a generalization of the "syncausality" approach of Ben-Zvi and Moses. We constructively show the equivalence of the solutions yielded by both approaches, and by combining them, derive strengthened versions of known results for some previously-defined special cases of this problem. Our analysis is conducted under minimal assumptions: we work in a continuous-time model with possibly infinitely many agents. The general results we obtain for this model reduce to stronger ones for discrete-time models with only finitely many agents. In order to distill the properties of such models that are significant to this reduction, we define several classes of naturally-occurring models, which in a sense separate the different results. We present both a more practical optimal solution, as well as a surprisingly simple condition for solvability, for timely coordinated response under these models. Finally, we show how our results generalize the results known for previously-studied special cases of this problem.
MEASURE RIGIDITY BEYOND UNIFORM HYPERBOLICITY: INVARIANT MEASURES FOR CARTAN ACTIONS ON TORI

We prove that every smooth action $\a$ of $\mathbb{Z}^k,k\ge 2$, on the $(k+1)$-dimensional torus whose elements are homotopic to corresponding elements of an action $\a_0$ by hyperbolic linear maps preserves an absolutely continuous measure. This is the first known result concerning abelian groups of diffeomorphisms where existence of an invariant geometric structure is obtained from homotopy data. We also show that both ergodic and geometric properties of such a measure are very close to the corresponding properties of the Lebesgue measure with respect to the linear action $\a_0$.
Prediction and Measurement of the Vibration and Acoustic Radiation of Panels Subjected to Acoustic Loading

Interior noise and sonic fatigue are important issues in the development and design of advanced subsonic and supersonic aircraft. Conventional aircraft typically employ passive treatments, such as constrained layer damping and acoustic absorption materials, to reduce the structural response and resulting acoustic levels in the aircraft interior. These techniques require significant addition of mass and only attenuate relatively high frequency noise transmitted through the fuselage. Although structural acoustic coupling is in general very important in the study of aircraft fuselage interior noise, analysis of noise transmission through a panel supported in an infinite rigid baffle (separating two semi-infinite acoustic domains) can be useful in evaluating the effects of active/adaptive materials, complex loading, etc. Recent work has been aimed at developing adaptive and/or active methods of controlling the structural acoustic response of panels to reduce the transmitted noise1. A finite element formulation was recently developed to study the dynamic response of shape memory alloy (SMA) hybrid composite panels (conventional composite panel with embedded SMA fibers) subject to combined acoustic and thermal loads2. Further analysis has been performed to predict the far-field acoustic radiation using the finite element dynamic panel response prediction3. The purpose of the present work is to validate the panel vibration and acoustic radiation prediction methods with baseline experimental results obtained from an isotropic panel, without the effect of SMA.
Influence of Sulfur for Oxygen Substitution in the Solvolytic Reactions of Chloroformate Esters and Related Compounds

The replacement of oxygen within a chloroformate ester (ROCOCl) by sulfur can lead to a chlorothioformate (RSCOCl), a chlorothionoformate (ROCSCl), or a chlorodithioformate (RSCSCl). Phenyl chloroformate (PhOCOCl) reacts over the full range of solvents usually included in Grunwald-Winstein equation studies of solvolysis by an addition-elimination (A-E) pathway. At the other extreme, phenyl chlorodithioformate (PhSCSCl) reacts across the range by an ionization pathway. The phenyl chlorothioformate (PhSCOCl) and phenyl chlorothionoformate (PhOCSCl) react at remarkably similar rates in a given solvent and there is a dichotomy of behavior with the A-E pathway favored in solvents such as ethanol-water and the ionization mechanism favored in aqueous solvents rich in fluoroalcohol. Alkyl esters behave similarly but with increased tendency to ionization as the alkyl group goes from 1° to 2° to 3°. N,N-Disubstituted carbamoyl halides favor the ionization pathway as do also the considerably faster reacting thiocarbamoyl chlorides. The tendency towards ionization increases as, within the three contributing structures of the resonance hybrid for the formed cation, the atoms carrying positive charge (other than the central carbon) change from oxygen to sulfur to nitrogen, consistent with the relative stabilities of species with positive charge on these atoms.
Static conflict analysis for multi-threaded object-oriented programs

A compiler for multi-threaded object-oriented programs needs information about the sharing of objects for a variety of reasons: to implement optimizations, to issue warnings, to add instrumentation to detect access violations that occur at runtime. An Object Use Graph (OUG) statically captures accesses from different threads to objects. An OUG extends the Heap Shape Graph (HSG), which is a compile-time abstraction for runtime objects (nodes) and their reference relations (edges). An OUG specifies for a specific node in the HSG a partial order of events relevant to the corresponding runtime object(s). Relevant events include read and write access, object escape, thread start and join.OUGs have been implemented in a Java compiler. Initial experience shows that OUGs are effective to identify object accesses that potentially conflict at runtime and isolate accesses that never cause a problem at runtime. The capabilities of OUGs are compared with an advanced program analysis that has been used for lock elimination. For the set of benchmarks investigated here, OUGs report only a fraction of shared objects as conflicting and reduce the number of compile-time reports in terms of allocation sites of conflicting objects by 28--92% (average 64%). For benchmarks of up to 30 KLOC, the time taken to construct OUGs is, with one exception, in the order of seconds.The information collected in the OUG has been used to instrument Java programs with checks for object races. OUGs provide precise information about object sharing and static protection, so runtime instrumentation that checks those cases that cannot be disambiguated at compile-time is sparse, and the total runtime overhead of checking for object races is only 3--86% (average 47%).
The minimax cache: an energy-efficient framework for media processors

This work is based on our philosophy of providing interlayer system-level power awareness in computing systems. Here, we couple this approach with our vision of multi-partitioned memory systems, where memory accesses are separated based on their static predictability and memory footprint and managed with various compiler controlled techniques. We show that media applications are mapped more efficiently when scalar memory accesses are redirected to a mini-cache. Our results indicate that a partitioned 8K cache with the scalars being mapped to a 512 byte mini-cache can be more efficient than a 16K monolithic cache from both performance and energy point of view for most applications. In extensive experiments, we report 30% to 60% energy-delay product savings over a range of system configurations and different cache sizes.
On the pharmacogenetics of non-small cell lung cancer treatment

ABSTRACT Introduction. Despite many clinical efforts, non-small-cell lung cancer (NSCLC) has a dismal 5-year survival rate of 16%, and high incidence of recurrence. The success of biologically targeted agents, as well as the activity of well-established chemotherapeutic regimens, has been limited by inherited/acquired resistance, and biomarkers to adapt the prescription of anticancer drugs to patients’ features are urgently warranted. Areas covered. In oncology, pharmacogenetics should provide the way to select patients who may benefit from a specific therapy that best match the individual and tumor genetic profile, thus allowing maximum activity and minimal toxicity. The present review summarizes the main findings on NSCLC pharmacogenetics, critically reappraising the most important studies on polymorphisms correlated with outcome of pemetrexed and EGFR-inhibitors, and provides perspective on clinical application of genomic tests for treatment decision-making. Expert Opinion. A major challenge in NSCLC is the identification of subgroups of diseases/patients that will truly benefit from specific treatments. Ideally, convenient and minimally invasive tests to decipher biomarkers of chemosensitivity/resistance and toxicity should be developed alongside novel anticancer treatments. Integration with the latest generation of whole-genome analyses and liquid biopsies as well as prospective validation in large cohorts of patients will overcome the limitations of the traditional pharmacogenetic approaches.
Effect of intensity and type of physical activity on mortality: results from the Whitehall II cohort study.

OBJECTIVES We examined the association of intensity and type of physical activity with mortality. METHODS We assessed the duration of physical activity by intensity level and type in 7456 men and women from the Whitehall II Study by questionnaire in 1997-1999 (mean ±SD age = 55.9 ± 6.0 years) and 5 years later. All-cause mortality was assessed until April 2009. RESULTS A total of 317 participants died during the mean follow-up of 9.6 years (SD = 2.7). Reporting at least 1 hour per week of moderate activity was associated with a 33% (95% confidence interval [CI] = 14%, 45%) lower risk of mortality compared with less than 1 hour. For all physical activity types examined, except housework, a duration of physical activity greater than 0 (≥ 3.5 hours for walking) was associated with lower mortality in age-adjusted analyses, but only the associations with sports (hazard ratio [HR] = 0.71; 95% CI = 0.56, 0.91) and do-it-yourself activity (HR = 0.68; 95% CI = 0.53, 0.98) remained in fully adjusted analyses. CONCLUSIONS It is important to consider both intensity and type of physical activity when examining associations with mortality.
Organics Captured from Comet 81P/Wild 2 by the Stardust Spacecraft

Organics found in comet 81P/Wild 2 samples show a heterogeneous and unequilibrated distribution in abundance and composition. Some organics are similar, but not identical, to those in interplanetary dust particles and carbonaceous meteorites. A class of aromatic-poor organic material is also present. The organics are rich in oxygen and nitrogen compared with meteoritic organics. Aromatic compounds are present, but the samples tend to be relatively poorer in aromatics than are meteorites and interplanetary dust particles. The presence of deuterium and nitrogen-15 excesses suggest that some organics have an interstellar/protostellar heritage. Although the variable extent of modification of these materials by impact capture is not yet fully constrained, a diverse suite of organic compounds is present and identifiable within the returned samples.
Improving the Manageability of Enterprise Topologies Through Segmentation, Graph Transformation, and Analysis Strategies

The software systems running in an enterprise consist of countless components, having complex dependencies, are hosted on physical or virtualized environments, and are scattered across the technical infrastructure of an enterprise, ranging from on-premise data centers up to public cloud deployments. The resulting topology of the current IT landscape of an enterprise is often extremely complex. We show that information about this complex ecosystem can be captured in a graph-based structure, the enterprise topology graph. We argue that, using such graph-based representation, many challenges in Enterprise Architecture Management (EAM) can be tackled through the aid of graph processing algorithms. However, the high complexity of an enterprise topology graph is the main obstacle to this approach. An enterprise topology graph may consist of millions of nodes, each representing an element of the enterprise IT landscape. Further, these nodes comprise a large variety of properties and relationships, making the topology hardly manageable by human users and software tools. To address this complexity problem, we propose different mechanisms to make enterprise topology graphs manageable. Segmentation techniques, tailored to specific use cases, extract manageable segments from the enterprise topology graph. Based on a set of formally defined transformation operations we then demonstrate the power of the approach in three application scenarios.
Large variation between hospitals and pathology laboratories in lymph node evaluation in colon cancer and its impact on survival, a nationwide population-based study in the Netherlands.

BACKGROUND adequate lymph node (LN) evaluation is important for planning treatment in patients with colon cancer. Aims of this study were to identify factors associated with adequate nodal examination and to determine its relationship with stage distribution and survival. PATIENTS AND METHODS data from patients with colon carcinoma stages I-III who underwent surgical treatment and diagnosed in the period 2000-2006 were retrieved from the Netherlands Cancer Registry. Multilevel logistic analysis was carried out to examine the influence of relevant factors on the number of evaluated LNs. The relationship with survival was analysed using Cox regression analysis. RESULTS the number of examined LN was determined for 30 682 of 33 206 tumours. Median number of evaluated LN was 8, ranging from 4 to 15 between pathology laboratories. Females, younger patients, right-sided pN+ tumours with higher pT stage and patients diagnosed in an academic centre were less likely to have nine or less LN evaluated. Unexplained variation between hospitals and pathology laboratories remained, leading to differences in stage distribution. With increasing number of evaluated LN, the risk of death decreased. CONCLUSION there was large diversity in nodal examination among patients with colon cancer, leading to differences in stage distribution and being associated with survival.
Reconstitution of human rRNA gene transcription in mouse cells by a complete SL1 complex

ABSTRACT An important characteristic of the transcription of a ribosomal RNA gene (rDNA) mediated by DNA-dependent RNA polymerase (Pol) I is its stringent species specificity. SL1/TIF-IB is a key complex for species specificity, but its functional complex has not been reconstituted. Here, we established a novel and highly sensitive monitoring system for Pol I transcription to reconstitute the SL1 activity in which a transcript harboring a reporter gene synthesized by Pol I is amplified and converted into translatable mRNA by the influenza virus RNA-dependent RNA polymerase. Using this monitoring system, we reconstituted Pol I transcription from the human rDNA promoter in mouse cells by expressing four human TATA-binding protein (TBP)-associated factors (TAFIs) in the SL1 complex. The reconstituted SL1 also re-activated human rDNA transcription in mouse A9 cells carrying an inactive human chromosome 21 that contains the rDNA cluster. Chimeric SL1 complexes containing human and mouse TAFIs could be formed, but these complexes were inactive for human rDNA transcription. We conclude that four human TAFIs are necessary and sufficient to overcome the barrier of species specificity for human rDNA transcription in mouse cells.
Randomised controlled trial demonstrates that fermented infant formula with short‐chain galacto‐oligosaccharides and long‐chain fructo‐oligosaccharides reduces the incidence of infantile colic

We examined the effects on gastrointestinal (GI) tolerance of a novel infant formula that combined specific fermented formula (FERM) with short‐chain galacto‐oligosaccharides and long‐chain fructo‐oligosaccharides (scGOS/lcFOS), with a 9:1 ratio and concentration of 0.8 g/100 mL.
Retrieval Goal Modulates Memory for Context

Abstract fMRI was employed to assess whether the contents of recollection vary according to retrieval goal. At study, visually presented words were superimposed on urban or rural scenes or a gray background. The word–background pairs were presented in one of three spatial locations. During a scanned test phase, studied and unstudied words were presented. Two different source memory tasks were randomly interleaved. In the “background” task, the requirement was to judge whether the word had been presented against one of the two classes of scene, as opposed to the alternate class or the gray background. In the “location” task, discrimination was between words presented in one of the two lateral locations and words presented in either of the alternate locations. In both tasks, unstudied words required a separate response. In the background task, words studied against scenes elicited greater activity in parahippocampal and retrosplenial cortex than did words studied against the gray background, consistent with prior reports of scene reinstatement effects. Reinstatement effects were also evident in the location task. Relative to the background task, however, the effects were attenuated in parahippocampal cortex. In other regions, including medial prefrontal and posterior cingulate cortex, activity elicited in the location task by items associated with scenes was lower than that elicited by items presented on the gray background. The findings are interpreted as evidence that contextual retrieval is partially modulated by retrieval goal.