Miracle-dz/UniFAR-FTUs huggingface dataset:
[Prognostic factors in unstable angina with dynamic electrocardiographic changes. Value of fibrinogen].

INTRODUCTION AND OBJECTIVES The prognosis of unstable angina varies between series depending on the inclusion criteria and management protocol used. The aim of this study was to analyze in-hospital events and their predictors in a homogeneous single-center series of patients with unstable angina. MATERIAL AND METHODS A total of 246 patients with the following inclusion criteria were studied: 1) resting anginal pain, 2) transient electrocardiographic changes during anginal pain, 3) normal CK-MB levels and 4) exclusion of postinfarction angina. All patients were treated with aspirin and enoxaparin (1 mg/kg/12 h). Coronary angiography was performed in the case of recurrent angina or ischemia in Bruce I-II stage during the predischarge effort stress test. The variables recorded were risk factors, history of ischemic heart disease, history of coronary surgery, ECG upon admission, and fibrinogen. RESULTS During the hospital stay the following events were recorded: 36% recurrent angina, 58% cardiac catheterization, and 5,7% major events (infarction or death). Multivariate analysis found recurrent angina to be more frequent in patients with a history of coronary bypass surgery (p = 0.004. OR = 22; CI 95%, 3-182), ST-segment changes (p = 0.01. OR = 4.7, CI 95%; 1.4-15.9) and higher fibrinogen (p = 0.002. OR = 1,4, CI 95%; 1.1-1.7). Fibrinogen was the only variable related to cardiac catheterization (p = 0,009. OR = 1.3. CI 95%, 1.1-1.6) and major events (p = 0.001. OR = 2.0. CI 95%, 1.4-3.1). CONCLUSIONS 1) Unstable angina with electrocardiographic changes was associated to a high rate of in-hospital events. 2) Fibrinogen was related to any event, and previous by-pass surgery and ST changes were related to recurrent angina.
Circulating endothelial progenitor cells in cardiovascular disorders

The role of vascular endothelium in cardiovascular disorders is well recognized. Mature endothelial cells contribute to the repair of endothelial injury, but only with a limited capacity. This has led to growing interest and further investigation into circulating endothelial progenitor cells (EPCs) and their role in vascular healing, repair and postnatal neovascularization. Recent studies have shown that EPCs are affected both in number and function by several cardiovascular risk factors as well as various cardiovascular disease states. Here, we aim to provide an overview of EPCs in humans, from methods of assessment to quantification and functional properties in numerous cardiovascular conditions. In addition, we hope to offer some perspective on the potential diagnostic and therapeutic aspects of EPCs.
Area-Efficient Embedded Resistive RAM (ReRAM) Macros Using Logic-Process Vertical-Parasitic-BJT (VPBJT) Switches and Read-Disturb-Free Temperature-Aware Current-Mode Read Scheme

The design of resistive RAM (ReRAM) faces two major challenges: 1) cell area versus write current requirements and 2) cell read current (ICELL) versus read disturbance. This paper proposes ReRAM macros using logic-process-based vertical parasitic-BJT (VPBJT) switches and a corresponding cell array (VPBJT-CA), resulting in a 4.5× macro density compared to conventional NMOS-switch ReRAM for given write current requirements. To overcome temperature-dependent fluctuations in the base-emitter voltage difference (VBE) of VPBJT, we propose a temperature-aware bitline (BL) voltage bias (VBL-R) (TABB) scheme to provide current-mode sensing with 4.7× larger ICELL and 1.6× faster read speeds. Test results of fabricated 0.18 μm 1 Mb and 65 nm 2 Mb VPBJT ReRAM macros confirm the efficacy of the temperature-aware VBL-R, resulting in sub-5-ns random read access times.
The mind considered as a system of meaning structures. II. Concepts and representations.

Lundh, L. -G. : The mind considered as a system of meaning structures. 11. Concepts and representations. Scandinavian Journnl of Psychology, 1982,23, 225-242. The theory of the mind considered as a system of meaning structures, which was sketched in an earlier paper (Lundh, 1981), is developed further in this paper. Whereas the earlier paper remained at a prelinguistic, sensorimotor level of functioning, the present paper extends the theory to conceptual thinking. Three main distinctions are drawn: between 1) mental representations and symbols, 2) sensorimotor intelligence and conceptual intelligence, and 3) habitual inferences and cognitive operations. Sensorimotor development consists in the development of mental representations, which the child, however, does not yet have any conscious access to. It is argued that sensorimotor structures are transformed into conceptual and propositional structures to the extent that the child becomes able not only to act, but also to think in terms of these structures-the latter is equated with the development of a kind of conscious access to already existent mental representations. Lars-Gunnar Lundh, Leopoldsgatan 32, S-75441 Uppsalu, Sweden. In an earlier paper (Lundh, 1981), a theory of the mind considered as a system of meaning structures was developed for a pre-linguistic, purely sensorimotor level of intelligence. The result was a model of a psychological organism without language, thinking, introspective abilities and self-consciousness. The purpose of the present paper is to extend the theory so as to include also higher-order mental phenomena, and to move in the direction of constructing a model of the more complex kind of mind that adult human beings are equipped with. First a short resume will be made of the main points of the earlier paper. Resume. Four propositions 1. What is important in the field of psychology is not individual stimuli, but >lusses of eqirivalent stimuli. The existence of such classes, as evidenced in the organism’s dispositions to respond in the same way to different stimuli, implies the existence of a perceptual classification. The elements of such stimulus classes are said to mean the some to the organism.
Organizing to Gain from User Interaction : The Role of Organizational Practices for Absorptive and Innovative Capacities

We address how organizational practices may leverage the knowledge absorption from users in the context of innovation. We focus on practices that enhance communication and knowledge sharing between management and employees and between departments, and on pecuniary rewards for engaging in knowledge sharing. Such practices leverage knowledge absorption and lead to higher innovative capacity. Thus, we identify some of the organizational dimensions of absorptive capacity that are needed to benefit from the “user innovation model” and provide quantitative support for the propositions put forward. The paper draws on a survey of 169 Danish private firms. The survey was implemented in 2001 among a sample of the 1000 largest Danish manufacturing and service firms.
Alcoholics Anonymous and Reduced Impulsivity: A Novel Mechanism of Change

Reduced impulsivity is a novel, yet plausible, mechanism of change associated with the salutary effects of Alcoholics Anonymous (AA). Here, the authors review their work on links between AA attendance and reduced impulsivity using a 16-year prospective study of men and women with alcohol use disorders (AUDs) who were initially untreated for their drinking problems. Across the study period, there were significant mean-level decreases in impulsivity, and longer AA duration was associated with reductions in impulsivity. In turn, decreases in impulsivity from baseline to Year 1 were associated with fewer legal problems and better drinking and psychosocial outcomes at Year 1, and better psychosocial functioning at Year 8. Decreases in impulsivity mediated associations between longer AA duration and improvements on several Year 1 outcomes, with the indirect effects conditional on participants’ age. Findings are discussed in terms of their potential implications for research on AA and, more broadly, interventions for individuals with AUDs.
Altered Gene Response to Aflatoxin B1 in the Spleens of Susceptible and Resistant Turkeys

Susceptibility and/or resistance to aflatoxin B1 (AFB1) is a threshold trait governed principally by glutathione S transferase (GST)-mediated detoxification. In poultry, domesticated turkeys are highly sensitive to AFB1, most likely due to dysfunction in hepatic GSTs. In contrast, wild turkeys are comparatively resistant to aflatoxicosis due to the presence of functional hepatic GSTAs and other possible physiological and immunological interactions. The underlying genetic basis for the disparate GST function in turkeys is unknown as are the broader molecular interactions that control the systemic response. This study quantifies the effects of dietary AFB1 on gene expression in the turkey spleen, specifically contrasting genetically distinct domesticated (DT, susceptible) and Eastern wild (EW, resistant) birds. Male turkey poults were subjected to a short-term AFB1 treatment protocol with feed supplemented with 320 ppb AFB1 beginning on day 15 of age and continuing for 14 days. Spleen tissues were harvested and subjected to deep RNA sequencing and transcriptome analysis. Analysis of differential gene expression found the effects of AFB1 treatment on the spleen transcriptomes considerably more prominent in the DT birds compared to EW. However, expression of the differentially expressed genes (DEGs) was directionally biased, with the majority showing higher expression in EW (i.e., down-regulation in DT). Significantly altered pathways included FXR/RXR and LXR/RXR activation, coagulation system, prothrombin activation, acute phase response, and atherosclerosis signaling. Differential extra-hepatic expression of acute phase protein genes was confirmed by quantitative real time PCR (qRT-PCR) in the original experiment and additional turkey lines. Results demonstrate that wild turkeys possess a capacity to more effectively respond to AFB1 exposure.
Coherent Conformational Degrees of Freedom as a Structural Basis for Allosteric Communication

Conformational changes in allosteric regulation can to a large extent be described as motion along one or a few coherent degrees of freedom. The states involved are inherent to the protein, in the sense that they are visited by the protein also in the absence of effector ligands. Previously, we developed the measure binding leverage to find sites where ligand binding can shift the conformational equilibrium of a protein. Binding leverage is calculated for a set of motion vectors representing independent conformational degrees of freedom. In this paper, to analyze allosteric communication between binding sites, we introduce the concept of leverage coupling, based on the assumption that only pairs of sites that couple to the same conformational degrees of freedom can be allosterically connected. We demonstrate how leverage coupling can be used to analyze allosteric communication in a range of enzymes (regulated by both ligand binding and post-translational modifications) and huge molecular machines such as chaperones. Leverage coupling can be calculated for any protein structure to analyze both biological and latent catalytic and regulatory sites.
Stock Market Information and Reit Earnings Management

This paper investigates the interaction between stock price movement and REIT earnings management. We examine whether information generated from stock trading influences managers' incentives to engage in earnings management. We first test if stock investors are able to detect earnings management by examining whether REITs that are suspected of engaging in earnings management have fundamental values less closely tracked by their stock prices. Consistent with the efficient markets hypothesis, we find that suspected earnings- management firms do not appear to be more mispriced than others. We further inquire into the feedback effect of stock market trading activity on earnings management. Using idiosyncratic volatility as a measure of private information embedded in stock price, we find that negative real earnings management, which allows REITs to circumvent the mandatory dividend payout requirement, is associated with greater information embedded in REIT stock prices. Our result implies that information contained in stock price volatility motivates REIT managers to more actively avoid regulatory costs.
Structural Similarity based image quality map for face recognition across plastic surgery

Variations in the face appearance caused by plastic surgery on skin texture and geometric structure, can impair the performance of most current face recognition systems. In this work, we proposed to use the Structural Similarity (SSIM) quality map to detect and model variations due to plastic surgeries. In the proposed framework, a S-SIM index weighted multi-patch fusion scheme is developed, where different weights are provided to different patches in accordance with the degree to which each patch may be altered by surgeries. An important feature of the proposed approach, also achieving performance comparable with the current state-of-the-art, is that neither training process is needed nor any background information from other datasets is required. Extensive experiments conducted on a plastic surgery face database demonstrate the potential of SSIM map for matching face images after surgeries.
A new wearable fingertip haptic interface for the rendering of virtual shapes and surface features

This work presents the Haptic Thimble, a novel wearable haptic device for surface exploration. The Haptic Thimble combines rendering of surface orientation with fast transient and wide frequency bandwidth tactile cues. Such features allow surface exploration with rich tactile feedback, including reactive contact - no contact transition, rendering of collisions, surface asperities and textures. Above capabilities were obtained through a novel serial kinematics wrapped around the finger, actuated by compact servo motor for orienting the last link, and by a custom voice coil for actuating the plate in contact with the fingerpad. Performance of the voice coil were measured at the bench in static and dynamic conditions, assessing the capability of reproducing generic, wide-bandwidth (0-300 Hz) tactile cues. Overall usability of the Haptic Thimble was explored within a virtual environment involving exploration of virtual surfaces. Finally, a perceptual experiment executed in a teleoperated environment with kinesthetic feedback, showed that the addition of tactile feedback, provided through the Haptic Thimble, significantly improved performance of an exploratory task.
Disclosure of Intimate Partner Violence to Informal Social Support Network Members

This article presents a review of the published literature to date on rates, experiences, and correlates of victims’ disclosure of or help seeking for intimate partner violence to informal social support network members (e.g., friends, family, classmates, and coworkers). Research indicates that the majority of individuals disclose to at least one informal support and that victims’ disclosure is associated with a number of demographic (e.g., victims’ sex, age, race), intrapersonal (e.g., victims’ feelings of shame/embarrassment, perception of control over abuse), and situational (e.g., violence frequency and severity, if abuse is witnessed) factors. Following disclosure, victims experience a wide range of positive (e.g., believing the victim’s reports, validating the victim’s experiences) and negative (e.g. disbelieving, blaming the victim) social reactions, with positive reactions rated as the most common and most helpful forms of support by victims. Finally, a review of psychological correlates associated with reactions to disclosure indicates that positive social reactions are associated with more psychological health benefits and fewer negative health symptoms, whereas negative social reactions were associated with increased negative psychological health symptoms. Future research methodologies and implications for violence prevention, intervention, and policy are discussed.
Determinants of E-WOM Influence: The Role of Consumers' Internet Experience

Research has widely demonstrated that personal sources of information are more influential than firm-generated sources. The potential impact of others' opinions has dramatically increased with the development of the Internet. However, very little is known about what makes certain opinions more influential than others. The purpose of this paper is to examine the determinants of electronic word of mouth (e-WOM) influence. We demonstrate that the influence of e-WOM depends on source credibility, valence, and the volume of information obtained from e-WOM. More interestingly, we also find that there exists a quadratic relationship between consumers' Internet experience and e-WOM influence.
The Effects of Organizational Justice Perceptions Associated with the use of Electronic Monitoring on Employees' Organizational Citizenship and Withdrawal Behaviours: A Social Exchange Perspective

The number of organizations choosing to electronically monitor their employees is increasing. Many of these organizations choose to implement these systems without fully understanding what effect they will have on their employees’ attitudes and behaviours. The current study explored how fairness perceptions associated with the use of electronic monitoring impacts the extent to which employees are willing to engage in two types of discretionary behaviours—organizational citizenship and withdrawal behaviours. A social exchange approach was adopted. Data were obtained from 208 employees working for a Municipal government, a Police department and a call centre. Results confirmed that perceptions of justice associated with the use of electronic monitoring affect employees’ willingness to engage in both organizational citizenship and withdrawal behaviours. It was also found that the relationship between perceptions of fairness associated with the use of electronic monitoring and citizenship and withdrawal behaviours was mediated by perceived organizational support, organizational trust, and affective commitment. Overall, the findings of the current study contribute to our understanding of the factors influencing employees’ willingness to engage in loyal boosterism and withdrawal behaviours when organizations electronically monitor their employees. Practical and theoretical implications are discussed.
From Spiking Neuron Models to Linear-Nonlinear Models

Neurons transform time-varying inputs into action potentials emitted stochastically at a time dependent rate. The mapping from current input to output firing rate is often represented with the help of phenomenological models such as the linear-nonlinear (LN) cascade, in which the output firing rate is estimated by applying to the input successively a linear temporal filter and a static non-linear transformation. These simplified models leave out the biophysical details of action potential generation. It is not a priori clear to which extent the input-output mapping of biophysically more realistic, spiking neuron models can be reduced to a simple linear-nonlinear cascade. Here we investigate this question for the leaky integrate-and-fire (LIF), exponential integrate-and-fire (EIF) and conductance-based Wang-Buzsáki models in presence of background synaptic activity. We exploit available analytic results for these models to determine the corresponding linear filter and static non-linearity in a parameter-free form. We show that the obtained functions are identical to the linear filter and static non-linearity determined using standard reverse correlation analysis. We then quantitatively compare the output of the corresponding linear-nonlinear cascade with numerical simulations of spiking neurons, systematically varying the parameters of input signal and background noise. We find that the LN cascade provides accurate estimates of the firing rates of spiking neurons in most of parameter space. For the EIF and Wang-Buzsáki models, we show that the LN cascade can be reduced to a firing rate model, the timescale of which we determine analytically. Finally we introduce an adaptive timescale rate model in which the timescale of the linear filter depends on the instantaneous firing rate. This model leads to highly accurate estimates of instantaneous firing rates.
Mathematical Programs with Cardinality Constraints: Reformulation by Complementarity-Type Conditions and a Regularization Method

Optimization problems with cardinality constraints are very difficult mathematical programs which are typically solved by global techniques from discrete optimization. Here we introduce a mixed-integer formulation whose standard relaxation still has the same solutions (in the sense of global minima) as the underlying cardinality-constrained problem; the relation between the local minima is also discussed in detail. Since our reformulation is a minimization problem in continuous variables, it allows us to apply ideas from that field to cardinality-constrained problems. Here, in particular, we therefore also derive suitable stationarity conditions and suggest an appropriate regularization method for the solution of optimization problems with cardinality constraints. This regularization method is shown to be globally convergent to a Mordukhovich-stationary point. Extensive numerical results are given to illustrate the behavior of this method.
Corporate Hedging: The Impact of Financial Derivatives on the Broad Credit Channel of Monetary Policy

This complementary paper to Froot, Scharfstein, and Stein (1993) seeks to explore some of the corporate finance foundations of monetary economics. In particular, we investigate the impact of corporate risk management strategies on the monetary transmission mechanism. We employ a simple model of a financial accelerator (synonymously: a broad credit channel of monetary policy transmission) to argue that information asymmetries - which are at the heart of these models of the transmission mechanism - create incentives for corporate hedging programmes, that is, cash flow management. These policies, in turn, diminish the impact of monetary policy measures, which is reduced to the pure cost-of-capital effect.
Losartan reduced connexin43 expression in left ventricular myocardium of spontaneously hypertensive rats

ObjectiveTo assess the effect of angiotensin II type 1 (AT1) receptor antagonist losartan on myocardium connexin43 (Cx43) gap junction (GJ) expression in spontaneously hypertensive rats (SHRs) and investigate possible mechanisms.MethodsSixteen 9-week-old male SHRs and 8 age-matched male Wistar-Kyoto (WKY) rats were included in this study. SHRs were randomly divided into two groups to receive losartan at 30 mg/(kg·d) by oral gavage once daily for 8 weeks (SHR-L) or vehicle (0.9% saline) to act as controls (SHR-V); WKY rats receiving vehicle for 8 weeks served as normotensive controls. At the end of the experiment, rats were sacrificed and the hearts were removed. Expressions of Cx43 and nuclear factor-kappaB p65 (NF-κB p65) proteins in all three groups were observed and further investigations on the effect of angiotensin II type 1 receptor antagonist losartan (30 mg/(kg·d), 8 weeks) on Cx43 expression were conducted with Western blot and immunohistochemistry. NF-κB p65 protein in nuclear extracts was determined by Western blot.ResultsLeft ventricular (LV) hypertrophy was prominent in SHRs, Cx43 and NF-κB p65 protein expressions were obviously upregulated and Cx43 distribution was dispersed over the cell surface. Treatment with losarton reduced the over-expressions of Cx43 and NF-κB p65 in LV myocardium. The distribution of Cx43 gap junction also became much regular and confined to intercalated disk after losartan treatment.ConclusionCx43 level was upregulated in LV myocardium of SHR during early stage of hypertrophy. Angiotensin II type 1 receptor antagonist losartan prevented Cx43 gap junction remodeling in hypertrophied left ventricles, possibly through the NF-κB pathway.