Miracle-dz/UniFAR-FTUs huggingface dataset:
Corticotropin-releasing hormone: An autocrine hormone that promotes lipogenesis in human sebocytes

Sebaceous glands may be involved in a pathway conceptually similar to that of the hypothalamic-pituitary-adrenal (HPA) axis. Such a pathway has been described and may occur in human skin and lately in the sebaceous glands because they express neuropeptide receptors. Corticotropin-releasing hormone (CRH) is the most proximal element of the HPA axis, and it acts as central coordinator for neuroendocrine and behavioral responses to stress. To further examine the probability of an HPA equivalent pathway, we investigated the expression of CRH, CRH-binding protein (CRH-BP), and CRH receptors (CRH-R) in SZ95 sebocytes in vitro and their regulation by CRH and several other hormones. CRH, CRH-BP, CRH-R1, and CRH-R2 were detectable in SZ95 sebocytes at the mRNA and protein levels: CRH-R1 was the predominant type (CRH-R1/CRH-R2 = 2). CRH was biologically active on human sebocytes: it induced biphasic increase in synthesis of sebaceous lipids with a maximum stimulation at 10−7 M and up-regulated mRNA levels of 3β- hydroxysteroid dehydrogenase/Δ5–4 isomerase, although it did not affect cell viability, cell proliferation, or IL-1β-induced IL-8 release. CRH, dehydroepiandrosterone, and 17β-estradiol did not modulate CRH-R expression, whereas testosterone at 10−7 M down-regulated CRH-R1 and CRH-R2 mRNA expression at 6 to 24 h, and growth hormone (GH) switched CRH-R1 mRNA expression to CRH-R2 at 24 h. Based on these findings, CRH may be an autocrine hormone for human sebocytes that exerts homeostatic lipogenic activity, whereas testosterone and growth hormone induce CRH negative feedback. The findings implicate CRH in the clinical development of acne, seborrhea, androgenetic alopecia, skin aging, xerosis, and other skin disorders associated with alterations in lipid formation of sebaceous origin.
To Risk or Not to Risk? Uses and Limitations of Mary Douglas on Risk-Acceptability for Understanding Health and Safety at Work and Road Accidents

The recent Greening of politics in the West has encouraged rapid development of research into both environmental hazards and risk perceptions among the public. There are also longstanding traditions of research into behaviour under risk in such disparate fields as superpower relations (Allison 1971), inter-country commercial transactions, the economics of uncertainty, and the study of natural disasters (Torry 1979). Relatively few sociologists or social anthropologists have contributed. A major exception is Mary Douglas (1982, 1985, 1987). This paper is an attempt to make use of her work and to tests its limits, in answering two empirical questions: How do managers and workers address workplace hazards? And, how do motorcyclists and drivers behave on the roads?
A Reactive and Scalable Unicast Solution for Video Streaming over VANETs

Vehicular ad hoc networks (VANETs) are no longer a futuristic promise but rather an attainable technology. The majority of services envisioned for VANETs either require the provisioning of multimedia support or have this support as an extremely beneficial feature. However, the highly dynamic topology of VANETs poses a demanding challenge for the fulfillment of the stringent requirements for video streaming. In this paper, we provide a deep understanding of the issue of unicast video streaming over VANETs and propose a novel protocol, VIRTUS. In video streaming, many packets are transmitted consecutively in a short period of time. VIRTUS takes this into consideration and extend the duration of the decision of nodes to forward packets from a single transmission to a time window. Furthermore, VIRTUS calculates the suitability of a node to relay packets based on a balance between geographic advancement and link stability. We also propose an extension, that separates the process of relay node selection from the transmission of video content and adopts a density-aware mechanism that adapts its behavior according to local density. Consequently, VIRTUS makes use of the reactive aspect of receiver-based solutions while remaining scalable to increases in transmission rates and density. We report through extensive realistic experiments the benefits of using VIRTUS towards delivering video at a higher quality, in a timely fashion, with lower overhead and fewer collisions.
Curcumin Protects against CCl4-Induced Liver Fibrosis in Rats by Inhibiting HIF-1α Through an ERK-Dependent Pathway

The ERK/HIF-1α signaling pathway is believed to play an important role in the genesis of progressive fibrosis. An increasing expression of HIF-1α and ERK accompanies CCl4-induced liver fibrosis in rats. Curcumin is verified to have antifibrotic effects in several kinds of liver fibrosis models. There is no specific evidence illustrating a connection between curcumin and the HIF-1α/ERK pathway in rat liver fibrosis induced by CCl4. In this study, liver fibrosis was induced by CCl4 in treated rats. The data demonstrated that curcumin was able to attenuate liver fibrosis and inhibit the proliferation of HSC. Moreover, curcumin could remarkably elevate the hepatic function by decreasing serum levels of ALT, AST and ALP, and increasing levels of ALB, TP and α-SMA, Col III mRNA expression. Meanwhile, ECM status could also be reflected by curcumin treatment. The alleviation with curcumin treatment was associated with inhibition of HIF-1α and phosphor-ERK. This study indicates that curcumin alleviates fibrosis by reducing the expression of HIF-1α partly through the ERK pathway.
Decentralized access point selection architecture for wireless LANs /sub e/ployability and robustness

According to the spread of wireless LAN, multiple access points (AP) will be much more likely to be available there for stations (STA), which can roam from one AP to another by some rule. Consequently, the following significant issue can arise in those cases: how to select an appropriate AP among available AP. In the existing architecture, the received signal strength is usually used to select an AP. However, such an AP selection strategy causes the concentration of STA to specific AP and STA cannot use the resources of wireless LAN effectively. Hence, we propose decentralized AP selection strategies, and show that the proposed strategies can achieve an efficient and fair share of wireless access resources. Then, we examine deployability and robustness of our decentralized architecture from a practical viewpoint. The proposed architecture should be deployed without hurting the performance of the common existing architecture currently widely deployed. Therefore, the deployability of our architecture is examined in this respect. Furthermore, in addition to static characteristics, the dynamic behavior of the proposed architecture is studied to examine its robustness against some dynamic changes of situation due to AP breakdown and bursty arrivals of STA. Our simulation results show that the proposed architecture has excellent features in terms of both of deployability and robustness.
Subjective Wellbeing Between Organizational Bonds and Cultural Contaminations

Positive Psychology has recently attempted at “enlarging the paradigm,” explaining the understanding of the human experience of the world. By contrast, for Critical Psychology, “enlarging the paradigm” means moving away from an individualist conceptualization of the psychological. The present article aims at “redistributing the Psychological” toward directions already marked by cultural and discursive conceptions of human experience. Within a transdisciplinary frame, labeled as Psycho-semiotics, Diatextual Analysis has been adopted to investigate the rhetorical modes used by socially excluded enunciators (drug users, immigrants, atypical workers, elderly people, and some categories of churchgoer) to elaborate their own experience of well-being through affective labor and self care.
Associations between problem gambling, socio-demographics, mental health factors and gambling type: sex differences among Finnish gamblers

This study examined associations between problem gambling and type of gambling engagement (online, land-based or both), psychological distress, alcohol-related problems and demographics among male (n = 1438) and female (n = 1546) past-year gamblers in Western Finland. In this sample, 7.6% of men and 3.1% of women were screened as problem gamblers. Logistic regression analyses were used to study the associations for men and women separately. Among men, engaging in both land-based and online gambling or engaging in online gambling only and psychological distress increased the risk of problem gambling. Among women, engaging in both land-based and online gambling and alcohol-related problems were significantly associated with problem gambling. The findings further highlight the need to consider sex differences in preventive and treatment initiatives and policies targeting problem gambling. Online gambling seems to have stronger links with problem gambling, which motivates further research in the eventual harmfulness of this gambling form.
Summary of the 2016 Partners against Mortality in Epilepsy (PAME) Conference

Authors: Kevin D Graber, MD, Jeffrey Buchhalter, MD, PhD, Elson So, MD, Rainer Surges, MD, Detlev Boison, PhD, Franck Kalume, PhD, Cyndi Wright, Brian Gehlbach, MD, Jeff Noebels, MD, PhD, Vicky Whittemore, PhD, Elizabeth J. Donner, MD, MSc, Tom Stanton, MPP, Henry Smithson, MD, Jane Hanna, Masud Seyal, MD, PhD, Philippe Ryvlin, MD, PhD The third biannual Partners Against Mortality in Epilepsy (PAME) conference was held in Alexandria, VA from June 23–26, 2016. This was an intimate meeting of clinical and basic scientists, clinicians, people affected by Sudden Unexpected Death in Epilepsy Patients (SUDEP) in a loved one, people living with epilepsy and patient advocate organizations. Plenary sessions have been summarized by moderators, including: 1) Mortality in people with epilepsy: epidemiology and surveillance. 2) Mortality in children. 3) What do we know about the factors that predispose certain people to die from a seizure? 4) What are the events that occur during and after a seizure that cause a death in SUDEP? 5) What are the options for prevention now and in the future? 6) Advocacy perspectives: how can we speed up awareness and prevention? 7) Updates and discussion on select programs in mortality research. Breakout sessions allowed for a more focused audience. Those summarized here are: Frequent non-SUDEP causes of mortality in people with epilepsy; Mechanisms of SUDEP; Lessons learned in grief and how to better support families; Future directions for research to impact prevention; and How do we improve SUDEP risk disclosure? While significant progress has been made with review of human mortality in epilepsy and study of animal models, this meeting emphasized the need for: better understandings of the epidemiology of SUDEP, advances in the understandings of mechanisms, continued search for biomarkers and preventative measures, patient education, increased awareness, continued advocacy for patient and family support and research funding.
FTSPM: A Fault-Tolerant ScratchPad Memory

ScratchPad Memory (SPM) is an important part of most modern embedded processors. The use of embedded processors in safety-critical applications implies including fault tolerance in the design of SPM. This paper proposes a method, called FTSPM, which integrates a multi-priority mapping algorithm with a hybrid SPM structure. The proposed structure divides SPM into three parts: 1) a part is equipped with Non-Volatile Memory (NVM) which is immune against soft errors, 2) a part is equipped with Error-Correcting Code, and 3) a part is equipped with parity. The proposed mapping algorithm is responsible to distribute the program blocks among the above three parts with regards to their vulnerability level. The simulation results demonstrate that the FTSPM reduces the SPM vulnerability by about 7x in comparison to a pure SRAM-based SPM. In addition, the dynamic energy consumption of the proposed method is 77% and 47% less than that of a pure NVM-based SPM and a pure SRAM-based SPM, respectively.
Social Determinants of Racial Prejudice

In the sociology of racial prejudice, two major paradigms can be distinguished: Cultural-environmental and social class or conflict paradigms. On the basis of Durkheimian theory, it is hypothesized that cultural-environmental variables (education, knowledge) offer stronger and more consistent explanations of racial prejudice than status variables (self-perceived class position, occupational prestige, income). To test this hypothesis, National Opinion Research Center (NORC) data are analyzed. Findings corroborate the major cultural-environmental hypothesis that racial prejudice emerges from ritually dense sociocultural lifeforms. Little support is found for the claim that prejudice arises from class conflict and competition over material resources.
Do Endplate Noise and Spikes Arise from Normal Motor Endplates?

The concept that the endplate noise and endplate spike components of motor endplate potentials represent normal endplate potentials seems to be flawed. The morphology of the normal miniature endplate potentials described in the physiology literature is different from the morphology of the noise-like component of endplate potentials. This noise-like component is identified as normal in current electromyographic literature. There is strong experimental evidence that one source of the endplate noise component is grossly increased release (up to three orders of magnitude) of acetylcholine from the nerve terminal of that neuromuscular junction. The spikes can be accounted for by release of additional acetylcholine in response to mechanical stimulation by the electromyographic needle. Other possibilities exist.
What is this lesson about? Instructional processes and student understandings in writing classrooms

This article examines the extent to which classroom instruction conveyed challenging learning goals in writing through a range of teaching activities and how well the participating students understood those goals. We report an empirical study that examined the quality of writing instructional goals, how well they were conveyed to students through lesson activities and how the students came to understand them. Two different but converging theoretical perspectives of self-regulated learning and formative assessment were used as an analytical framework. Teachers' instructional practices during writing lessons were audio-taped in 17 different classrooms and a sample of students subsequently interviewed to assess their understanding of the dimensions of interest. The conditions monitored included the extent to which the lesson aims and mastery criteria were made explicit and how well feedback was aligned to those lesson aims. In most classes, students' interview responses reflected the extent to which teachers were explicit in these aspects of instructional practice. In general, when lesson aims and mastery criteria were unclear, students identified surface features of writing as their learning aims. When these lesson attributes were clearly articulated by the teacher, students were able to identify deeper features of writing as the lesson aims. When the aims were clear but the mastery criteria and lesson activities were misaligned, however, students identified surface features of writing as the lesson aims, rather than those articulated by the teacher.
Articular Cartilage Treatment in High-Level Male Soccer Players

Background: Soccer is a highly demanding sport for the knee joint, and chondral injuries can cause disabling symptoms that may jeopardize an athlete’s career. Articular cartilage lesions are difficult to treat, and the increased mechanical stress produced by this sport makes their management even more complex. Hypothesis: To evaluate whether the regenerative cell-based approach allows these highly demanding athletes a better functional recovery compared with the bone marrow stimulation approach. Study Design: Cohort study; Level of evidence, 2. Methods: Forty-one professional or semiprofessional male soccer players were treated from 2000 to 2006 and evaluated prospectively at 2 years and at a final 7.5-year mean follow-up (minimum, 4 years). Twenty-one patients were treated with arthroscopic second-generation autologous chondrocyte implantation (Hyalograft C) and 20 with the microfracture technique. The clinical outcome of all patients was analyzed using the cartilage standard International Cartilage Repair Society (ICRS) evaluation package. The sport activity level was evaluated with the Tegner score, and the recovery time was also recorded. Results: A significant improvement in all clinical scores from preoperative to final follow-up was found in both groups. The percentage of patients who returned to competition was similar: 80% in the microfracture group and 86% in the Hyalograft C group. Patients treated with microfracture needed a median of 8 months before playing their first official soccer game, whereas the Hyalograft C group required a median time of 12.5 months (P = .009). The International Knee Documentation Committee (IKDC) subjective score showed similar results at 2 years’ follow-up but significantly better results in the Hyalograft C group at the final evaluation (P = .005). In fact, in the microfracture group, results decreased over time (from 86.8 ± 9.7 to 79.0 ± 11.6, P < .0005), whereas the Hyalograft C group presented a more durable outcome with stable results (90.5 ± 12.8 at 2 years and 91.0 ± 13.9 at the final follow-up). Conclusion: Despite similar success in returning to competitive sport, microfracture allows a faster recovery but present a clinical deterioration over time, whereas arthroscopic second-generation autologous chondrocyte implantation delays the return of high-level male soccer players to competition but can offer more durable clinical results.
The Relationship of Academic Bargaining to Changes in Campus Climate

Scores on the Institutional Functioning Inventory (IFI) administered to faculty at 18 unionized and 18 matched non-unionized campuses in 1980 were compared to scores at these campuses prior to the implementation of academic bargaining a decade earlier. Results show no significant relationship between unionization and changes in campus climate as measured by the IFI. HE 016 606 27 pages MF $1.17 PC $5.45
CARMA: A Case-Based Rangeland Management Adviser

CARMA is an advisory system for rangeland grasshopper infestations that demonstrates how AI technology can deliver expert advice to compensate for cutbacks in public services. CARMA uses two knowledge sources for the key task of predicting forage consumption by grasshoppers: (1) cases obtained by asking a group of experts to solve representative hypothetical problems and (2) a numeric model of rangeland ecosystems. These knowledge sources are integrated through the technique of model-based adaptation, in which case-based reasoning is used to find an approximate solution, and the model is used to adapt this approximate solution into a more precise solution. CARMA has been used in Wyoming counties since 1996. The combination of a simple interface, flexible control strategy, and integration of multiple knowledge sources makes CARMA accessible to inexperienced users and capable of producing advice comparable to that produced by human experts. Moreover, because CARMA embodies diverse forms of expertise, it has been used in ways that its developers did not anticipate, including pest management research, development of industry strategies, and in-state and federal pest-management policy decisions.
New Variable-Number Tandem-Repeat Markers for Typing Mycobacterium avium subsp. paratuberculosis and M. avium Strains: Comparison with IS900 and IS1245 Restriction Fragment Length Polymorphism Typing

ABSTRACT Mycobacterium avium subsp. paratuberculosis, the etiological agent of paratuberculosis, affects a wide range of domestic ruminants and has been suggested to be involved in Crohn's disease in humans. Most available methods for identifying and differentiating strains of this difficult species are technically demanding and have limited discriminatory power. Here, we report the identification of novel PCR-based typing markers consisting of variable-number tandem repeats (VNTRs) of genetic elements called mycobacterial interspersed repetitive units (MIRUs). Eight markers were applied to 183 M. avium subsp. paratuberculosis isolates from bovine, caprine, ovine, cervine, leporine, and human origins from 10 different countries and to 82 human isolates of the closely related species M. avium from France. Among the M. avium subsp. paratuberculosis isolates, 21 patterns were found by MIRU-VNTR typing, with a discriminatory index of 0.751. The predominant R01 IS900 restriction fragment length polymorphism type, comprising 131 isolates, was divided into 15 MIRU-VNTR types. Among the 82 M. avium isolates, the eight MIRU-VNTR loci distinguished 30 types, none of which was shared by M. avium subsp. paratuberculosis isolates, resulting in a discriminatory index of 0.889. Our results suggest that MIRU-VNTR typing is a fast typing method that, in combination with other methods, might prove to be optimal for PCR-based molecular epidemiological studies of M. avium/M. avium subsp. paratuberculosis pathogens. In addition, presumably identical M. avium subsp. paratuberculosis 316F vaccine strains originating from the Weybridge laboratory and from different commercial batches from Mérial actually differed by one or both typing methods. These results indicate a substantial degree of genetic drift among different vaccine preparations, which has important implications for prophylactic approaches.
Increased Alpha (8–12 Hz) Activity during Slow Wave Sleep as a Marker for the Transition from Implicit Knowledge to Explicit Insight

The number reduction task (NRT) allows us to study the transition from implicit knowledge of hidden task regularities to explicit insight into these regularities. To identify sleep-associated neurophysiological indicators of this restructuring of knowledge representations, we measured frequency-specific power of EEG while participants slept during the night between two sessions of the NRT. Alpha (8–12 Hz) EEG power during slow wave sleep (SWS) emerged as a specific marker of the transformation of presleep implicit knowledge to postsleep explicit knowledge (ExK). Beta power during SWS was increased whenever ExK was attained after sleep, irrespective of presleep knowledge. No such EEG predictors of insight were found during Sleep Stage 2 and rapid eye movement sleep. These results support the view that it is neuronal memory reprocessing during sleep, in particular during SWS, that lays the foundations for restructuring those task-related representations in the brain that are necessary for promoting the gain of ExK.
The Three‐Component Model of Organisational Commitment: An Application to South Korea

We conducted two studies to determine whether the three-component model of organisational commitment (Meyer & Allen, 1991) is generalisable to a non-Western culture using data from South Korea. In Study 1, we found that when the 6-item versions of the scales (Meyer, Allen, & Smith, 1993) were translated into Korean, the psychometric properties of the Affective Commitment Scale were similar to those found in North America, but problems were identified in the Continuance and Normative Commitment Scales. In Study 2, we found that these problems could be overcome by adopting a revised set of items written in North America. The new scales demonstrated good psychometric properties in terms of factorial validity, internal consistency, and criterion-related validity with respect to turnover intention. We concluded that the three commitment constructs are likely to generalise to non-Western cultures, but that there might be a need to refine the measures for cross-cultural research.