Miracle-dz/UniFAR-FTUs huggingface dataset:
Depressed Mood, Gender, and Problem Drinking in Youth

ABSTRACT Background: Depressed mood and substance misuse are prevalent during adolescence, but rates differ between males and females. Little is known regarding how depressed mood influences response to substance use interventions and interacts with gender in connection with subsequent drinking. This study explores the relationship of depressed mood and gender to treatment response in adolescents admitted to an Emergency Department (ED) for alcohol-related incidents. Methods: Adolescents treated at an ED were randomly assigned to a Motivational Interviewing condition or to standard hospital care. Participants (N = 268; ages 13 to 19) were followed for 6 months with detailed measures of alcohol involvement and depressed mood. Results: Depressed mood at the time of the ED visit predicted less drinking at 6-month follow-up for 13- to 17-year-old girls, but predicted more follow-up drinking for 13- to 17-year-old boys and for 18- to 19-year-old females, above and beyond effects of baseline drinking. Depressed mood did not moderate the relationship between treatment condition and drinking outcome. Conclusions: Depressed mood as reported at the time of an ED visit appears to motivate drinking reductions in early- to mid-adolescent girls. Depressive symptoms may indicate an adaptive distress response to the event that precipitated the ED visit, which clinicians could capitalize on by heightening awareness of adverse risks and collaborating to set goals. In contrast, depression may be a liability in teenage boys and older teenage girls, and mood symptoms could be an additional target for intervention.
Motor evoked potentials in unilateral lingual paralysis after monohemispheric ischaemia

OBJECTIVES The occurrence of a lingual paralysis after unilateral upper motor neuron lesions is an infrequent clinical phenomenon, and the underlying pathophysiological mechanisms are poorly understood. We studied the cortical motor representations of ipsilateral and contralateral lingual muscles in healthy controls and in a selected group of stroke patients, to clarify the variable occurrence of a lingual paralysis after recent monohemispheric ischaemia. METHODS A special bipolar surface electrode was used to record the ipsilateral and contralateral compound muscle action potentials (CMAPs) from the lingual muscles after transcranial magnetic stimulation (TMS) of the human motor cortex and peripheral electrical stimulation (PES) of the hypoglossal nerve medial to the angle of the jaw. Four patients with a lingual paralysis (group 1) and four patients with symmetric lingual movements (group 2) after monohemispheric first ever stroke were studied and compared with 40 healthy controls. RESULTS In controls, TMS of either hemisphere invariably produces CAMPs in the ipsilateral and contralateral lingual muscles, elicited through crossed and uncrossed central motor pathways, respectively. In the 40 healthy controls, TMS of either hemisphere elicited CMAPs of significantly greater amplitudes and shorter onset latencies from the contralateral muscles compared with the ipsilateral responses (p<0.0001). In the patient groups, TMS of the affected hemisphere failed to evoke any CMAP from either lingual side; TMS of the unsevered hemisphere always produced normal ipsilateral and contralateral responses, irrespective of whether the ipsilateral muscles were paralysed or not. CONCLUSIONS Bilateral crossed and uncrossed corticonuclear projections are invariably existent in humans. After unilateral interruption of these pathways, some people do exhibit a lingual paralysis whereas others do not. The development of a central lingual paralysis is most likely dependent on the ability of the unsevered hemisphere to utilise the pre-existent uncrossed motor projections. The variable availability of these pathways among individual subjects is in good agreement with the inconstant occurrence of a lingual paralysis after restricted monohemispheric lesions.
Learning to lead: development for middle‐level leaders in higher education in England and Wales

There has been a significant increase in interest in the development of educational leadership in recent years, not least in the school sector. However, little research exists on how leaders in higher education have learnt to lead, particularly those in ‘middle‐leadership’ positions such as heads of faculties and departments. This study explores leadership development of 18 leader‐academics within six chartered and statutory universities in the south of Wales and the west of England. Semi‐structured biographical interviews were used between November 2005 and April 2006 to secure academics’ perceptions of the development experienced to equip them with the necessary attributes to lead. The findings show that formal professional development for leadership was relatively uncommon. The majority of what leaders do is learnt, self‐taught and acquired throughout their life history. This study captures insights which should inform the future research agenda in higher education and highlights the possible inadequacies of formal leadership development for leader‐academics in higher education. The challenge is to bring the informal processes of learning gained throughout a leader’s life history into a meaningful context for professional development. By doing so, training and development initiatives can be brought into the leader’s real world in a structured way to become more relevant and productive to those who participate. Strategies include the establishment of formal mentoring systems, encouraging the formation of networks and providing guided critical reflection on practice, whilst promoting opportunities for collective articulation and sharing of experiences. A suggested framework for integrated leadership development is proposed to enable middle‐level leader‐academics to experience more planned and meaningful development.
Research Vitality as Sustained Excellence: What Keeps the Plates Spinning?.

Purpose – Research vitality addresses the perseverance that faculty members in the organization sciences experience in maintaining their research quantity and quality over an extended period of time. The purpose of this paper is to offer a theoretical model of research vitality.Design/methodology/approach – The authors propose a model consisting of individual and situational factors which influence the motivation and commitment of a professor to continue to conduct quality research over an extended period of time. Additionally, the authors identify benefits that may accrue when faculty members possess research vitality and discuss human resource management implications for schools engaged in hiring, tenuring, promoting, and socializing faculty members. A set of propositions about research vitality and contextual factors that influence this construct are presented and discussed.Findings – An individual‐level construct that represents a time related measure of the quality and quantity of individual contribu.
Possible Role of Endothelial Thromboxane A2 in the Resting Tone and Contractile Responses to Acetylcholine and Arachidonic Acid in Canine Cerebral Arteries

Summary The amount of immunoreactive thromboxane B2 (TXB2) released from isolated canine arteries was determined by radioimmunoassay. The amount of TXB2 released from the cerebral, coronary, mesenteric, and saphenous arteries was 47.0 ± 7.2, 4.0 ± 0.6, 4.9 ± 0.5, and 2.7 ± 0.4 pg/mg wet weight tissue/30 min, respectively. The release of TXB2 from the cerebral artery was decreased to <5% by the administration of indomethacin (10-5 M) or OKY-046 (10-4 M), and by intimal rubbing. The release of TXB2 was enhanced nearly twofold by the addition of arachidonic acid (AA) (10-5 M) to the medium, but not by the addition of acetylcholine (ACh) (10-6 M). The cerebral arterial strips maintained the resting tone, which was reduced maximally by papaverine (10-4 M). The resting tone was also reduced dose dependently by a cyclooxygenase inhibitor (indomethacin), a thromboxane A2 (TXA2) synthetase inhibitor (OKY-046), and a TXA2 antagonist (ONO-3708). The resting tone of rubbed strips was about half that of intact strips. ACh and AA induced similar transient contractions in the cerebral artery. Contractions produced by these agents were attenuated by indomethacin (10-7 M), aspirin (5 × 10-5 M), OKY-046 (10-6 M), and ONO-3708 (10-8 M), and abolished by intimal rubbing. From these results, it is concluded that TXA2 is produced in the endothelial cells and may be involved in maintaining the resting tone and contractile response to AA in the canine cerebral artery.
Update on Alcoholic Hepatitis

Alcoholic liver disease is one of the most prevalent liver diseases worldwide, and a major cause of morbidity and mortality. Alcoholic hepatitis is a severe form of liver injury in patients with alcohol abuse, can present as an acute on chronic liver failure associated with a rapid decline in liver synthetic function, and consequent increase in mortality. Despite therapy, about 30%–50% of patients with severe alcoholic hepatitis eventually die. The pathogenic pathways that lead to the development of alcoholic hepatitis are complex and involve oxidative stress, gut dysbiosis, and dysregulation of the innate and adaptive immune system with injury to the parenchymal cells and activation of hepatic stellate cells. As accepted treatment approaches are currently limited, a better understanding of the pathophysiology would be required to generate new approaches that improve outcomes. This review focuses on recent advances in the diagnosis, pathogenesis of alcoholic hepatitis and novel treatment strategies.
Assessment of the AO/ASIF fracture classification for the distal tibia.

OBJECTIVES The purpose of this study was to assess the interobserver reliability and intraobserver reproducibility of the AO/ASIF and Rüedi and Allgöwer classifications for fractures of the distal tibia, and to determine the benefit of a computed tomography (CT) scan and experience on observer agreement for several fracture characteristics, including classification. METHODS The radiographs of forty-three fractures of the distal tibia, fourteen of which had CT scans, were assessed by groups of experienced and less-experienced observers. Each case was classified according to the AO/ASIF and Rüedi and Allgöwer systems. Several other fracture characteristics also were assessed. The kappa coefficient of agreement was calculated and used to compare the interobserver reliability and intraobserver reproducibility of the classification systems and to determine the benefit of experience and CT scans. The intraclass correlation coefficient was used to assess noncategoric data. RESULTS Interobserver and intraobserver agreements were good when classifying fractures into AO/ASIF types and significantly better than that for the Rüedi and Allgöwer system. However, agreement was poor when classifying the fractures into AO/ASIF groups. For most assessments, the experienced group tended to have higher levels of interobserver agreement, but not intraobserver agreement. Viewing the CT scans improved agreement on the percentage of articular surface involved, but it did not improve interobserver reliability or intraobserver reproducibility for either of the classification systems. CONCLUSION The AO/ASIF classification for fractures of the distal tibia has good observer agreement at the type level, but poor agreement at the group level. Experience tends to improve interobserver agreement, but not intraobserver agreement. Viewing CT scans does not improve agreement on classification, but it tends to improve agreement on articular surface involvement.
Task-modulated neural activation patterns in chronic stroke patients with aphasia

Background: Neuroimaging research on language recovery in patients with aphasia due to left hemisphere damage has generated some intriguing results. However, it is still not clear what role the right hemisphere plays in supporting recovered language functions in the chronic phase for patients with different site and size of lesion when different tasks are used. Aims: The present study aimed at exploring the role of perilesional, ipsilesional, and contralesional activation in participants with aphasia with different site and size of lesion using two different language tasks. All participants were in the chronic stage with well- recovered or significant improvements in language functions. Methods & Procedures: Functional magnetic resonance imaging (fMRI) was used to characterise brain activations in eight stroke patients and eight age/gender-matched controls during semantic judgement and oral picture naming. An event-related design using jittered interstimulus intervals (ISIs) was employed to present the stimuli. Outcomes & Results: The fMRI scans of both language tasks in patients revealed differences in activation pattern relative to the normal control participants. The nature of this difference was task specific. During the semantic judgement task patients without lesions involving the left frontal region activated the left inferior frontal gyrus similar to observations in the normal control participants. Participants with left frontal lesions activated contralesional regions in addition to perilesional left frontal regions. During the picture-naming task all participants activated bilateral brain regions irrespective of the site or size of lesion, consistent with other published studies utilising this task. Subsequent regions of interest analysis and laterality index analysis revealed that patients with large lesions produced greater right hemisphere activation than patients with small lesions. Conclusions: The results of this study demonstrate that recovery is task, lesion site, and size specific. Further, the results also indicate a role for both activation of homologous contralesional cortex and activity of left hemisphere regions (perilesional and ipsilesional) as efficient mechanisms for supporting language functions in chronic stroke patients.
Boolean and Vectorial Plateaued Functions and APN Functions

Boolean plateaued functions and vectorial functions with plateaued components play a significant role in cryptography, sequences for communications, and the related combinatorics and designs. Our knowledge on them is not at a level corresponding to their importance. We introduce new characterizations of plateaued Boolean functions. We give the characterizations of vectorial functions whose components are all plateaued (with possibly different amplitudes), that we simply call plateaued, by means of the value distributions of their derivatives (we characterize similarly those functions whose components are partially bent) and autocorrelation functions, and of the power moments of their Walsh transform. This allows us to derive several characterizations of almost perfect nonlinear (APN) functions in this framework. We prove that all the main results known for quadratic APN functions extend to plateaued functions, allowing the study of their APN-ness to be simplified. We show that if, additionally, the component functions are all unbalanced, this study is still simpler: the APN-ness of such functions depends only on their value distribution. This allows proving, for instance, that any plateaued (n, n)-function, n even, having similar value distribution as the APN power functions, is APN, and has the same extended Walsh spectrum as the APN Gold functions. As by-products, we obtain a few other new results. For instance, any plateaued function in even dimension, which is Carlet-Charpin-Zinoviev (CCZ)-equivalent to a Gold or Kasami APN function, is necessarily extended affine (EA)-equivalent to it.
The Pyrexia transient receptor potential channel mediates circadian clock synchronization to low temperature cycles in Drosophila melanogaster

Circadian clocks are endogenous approximately 24 h oscillators that temporally regulate many physiological and behavioural processes. In order to be beneficial for the organism, these clocks must be synchronized with the environmental cycles on a daily basis. Both light : dark and the concomitant daily temperature cycles (TCs) function as Zeitgeber (‘time giver’) and efficiently entrain circadian clocks. The temperature receptors mediating this synchronization have not been identified. Transient receptor potential (TRP) channels function as thermo-receptors in animals, and here we show that the Pyrexia (Pyx) TRP channel mediates temperature synchronization in Drosophila melanogaster. Pyx is expressed in peripheral sensory organs (chordotonal organs), which previously have been implicated in temperature synchronization. Flies deficient for Pyx function fail to synchronize their behaviour to TCs in the lower range (16–20°C), and this deficit can be partially rescued by introducing a wild-type copy of the pyx gene. Synchronization to higher TCs is not affected, demonstrating a specific role for Pyx at lower temperatures. In addition, pyx mutants speed up their clock after being exposed to TCs. Our results identify the first TRP channel involved in temperature synchronization of circadian clocks.
Nonlinear Modeling and Control of Servo Pneumatic Actuators

Pneumatic actuators are low-cost, safe, clean, and exhibit a high power to weight ratio. In this paper a new modeling approach and control law for pneumatic servo actuators are presented. The nonlinear system model is developed using a combination of mechanistic and empirical methods. The use of novel bipolynomial functions to model the valve flow rates is shown to produce a more accurate solution than prior approaches. A novel multiple-input single-output nonlinear position control law is designed using the backstepping methodology. The stability analysis includes the effects of friction modeling error and valve modeling error. Experiments are conducted with 9.5-mm bore and 6.4-mm bore pneumatic cylinders, and four low-cost two-way proportional valves. In experiments with the 9.5-mm bore cylinder and a 1.5-kg moving mass, maximum tracking errors of plusmn0.5 mm for a 1-Hz sine wave trajectory, and steady-state errors within plusmn0.05 mm for an S-curve trajectory were achieved.
Credit Cycles Redux

Theoretical studies have shown that under unorthodox assumptions on preference and production technologies, collateral constraints can act as a powerful amplification and propagation mechanism of exogenous shocks. We investigate whether or not this result holds under more standard assumptions. We find that collateral constraints generate a typically small output amplification. Large amplification is a "knife-edge" type of result.
WJ-40: Implicature, truth, and meaning

40-plus years ago Paul Grice initiated modern pragmatics by defining a relation of conversational implicature within a general theory of cooperation and rationality. While critics have disputed the formulation and derivation of Gricean principles, the overall framework, with appropriate emendations, remains the most natural and explanatory approach to predicting constraints on lexical incorporation, the behavior of scalar predicates, pragmatic strengthening, and other linguistic phenomena. Despite recent arguments for an enriched conception of propositional content, a range of real and fictional exchanges bearing on the distinction between lying and misleading supports the neo-Gricean view of an austere conception of what is said.
Police Officers' Views of Effective Interview Tactics with Suspects: The Effects of Weight of Case Evidence and Discomfort with Ambiguity

This study examined the effects of case-specific facts and individual discomfort with ambiguity (DA) on investigators' beliefs concerning effective interviewing tactics for suspects. Violent crime investigators (n = 30) responded to a questionnaire including the Need for Closure Scale (NFCS) and ratings of the importance of 39 interrogation tactics in two hypothetical interrogations with a homicide suspect, where the evidence consisted of either technical evidence or soft information. Twenty tactics were analysed with a multidimensional scaling procedure which confirmed two discrete interviewing themes: humane and dominant. More tactics, both dominant and humane, were rated as important if the evidence was soft compared with technical. In the soft evidence condition, investigators who were high on DA rated both types of tactics as more important than did low-DA investigators. In the technical evidence condition, no such difference emerged. Copyright © 2008 John Wiley & Sons, Ltd.
The De Facto Privatization of American Public Higher Education

Editor's note: On the trends in state support per student ', three of the authors in this issue (Lyall, Longanecker, and Ehrenberg) differ, depending on the inflation adjustors (the CPI or the more generous Higher Education Price Index, or HEPI) and beginning and ending years they use. Their respective sources calculate that support has declined by 12 percent (Lyall), increased by 0.08 percent (Longanecker), or declined by 0.6 percent (Ehrenberg), respectively. See Peter EwelVs article, "Power in Numbers: The Values in Our Metrics," in the July/August 2005 Change.
T cell leukemia-associated human Notch/translocation-associated Notch homologue has I kappa B-like activity and physically interacts with nuclear factor-kappa B proteins in T cells

Translocation-associated Notch homologue (TAN-1), a gene originally cloned from the translocation breakpoint of a human T cell leukemia carrying a 9:7(q34.3) translocation, encodes a protein belonging to the Notch/Lin-12/Glp-1 receptor family. These receptors mediate the specification of numerous cell fates during development in invertebrates and vertebrates. The intracellular portion of Notch/TAN-1 contains six ankyrin repeats that are similar to those found in cytoplasmic I kappa B proteins. I kappa B proteins are specific inhibitors of nuclear factor (NF)-kappa B/Rel transcription factors. Here we show that TAN-1 has functional properties of an I kappa B-like regulator with specificity for the NF-kappa B p50 subunit. A recombinant polypeptide corresponding to the cytoplasmic portion of TAN- 1 (TAN-1C) specifically inhibited the DNA binding of p50-containing NF- kappa B complexes. When overexpressed in an appropriate cell line, TAN- 1C prevented kappa B-dependent transactivation in transient reporter gene assays in a fashion similar to the structurally related protein, Bcl-3. TAN-1C could activate kappa B-dependent gene expression by attenuating the inhibitory effect of an excess of p50 homodimers. Immunoprecipitation experiments showed that the TAN-1 from a T cell line is associated with NF-kappa B containing p50 and p65 subunits. These observations indicate that TAN-1C may directly engage NF-kappa B transcription factors and modulate nuclear gene expression.