Miracle-dz/UniFAR-FTUs huggingface dataset:
Onetoone Emarketing Strategy Alignment: Five Internet Case Studies Onetoone Emarketing Strategy Alignment: Five Internet Case Studies Onetoone Emarketing Strategy Alignment: Five Internet Case Studies

Despite widespread adoption of new online business models and the rise of online or eMarketing using the Internet (Net) and its current graphical face the World Wide Web (Web), there remains a need for empirical research into specific aspects of eMarketing strategy beyond clickthrough analysis, Web audience analysis and scrutiny of Websites properties to mention the most widely examined elements. This paper discusses Peppers and Rogers (1999) OnetoOne strategy matrix and synthesises their approach with a series of personal interviews with business managers, drawn from a broader empirical study. It does so in an endeavour to improve outcomes from eMarketing strategy and the use of individual Net technologies. The aim is to aid both business practitioner and academician alike in further improving the effectiveness and efficiency gained from using converging technologies in eBusiness. University) of Managing on the Internet, now in its second edition. His other publications are in information technology, while his research and teaching interests are in eMarketing-particularly 'small-world' network phenomena in eMarketing communication. Abstract Despite widespread adoption of new online business models and the rise of online or eMarketing using the Internet (Net) and its current graphical face the World Wide Web (Web), there remains a need for empirical research into specific aspects of eMarketing strategy beyond clickthrough analysis, Web audience analysis and scrutiny of Websites properties to mention the most widely examined elements. This paper discusses Peppers and Rogers (1999) OnetoOne strategy matrix and synthesises their approach with a series of personal interviews with business managers, drawn from a broader empirical study. It does so in an endeavour to improve outcomes from eMarketing strategy and the use of individual Net technologies. The aim is to aid both business practitioner and academician alike in further improving the effectiveness and efficiency gained from using converging technologies in eBusiness. Introduction Despite widespread adoption of new online business models and the rise of online or eMarketing using the Internet (Net) and its current graphical face the World Wide Web (Web), little empirical research has been undertaken into specific aspects of eMarketing beyond clickthrough analysis and Web audience analysis to cite a sample of such published research.
Differential Interstrain Susceptibility to Vertebrobasilar Dolichoectasia in a Mouse Model

BACKGROUND AND PURPOSE: Vetebrobasilar dolichoectasia is characterized by arterial elongation, dilation, and tortuosity and leads to high risks of ischemic stroke. Our aim was to investigate the differential susceptibility to elastase-induced vertebrobasilar dolichoectasia induction in 2 different mouse strains. MATERIALS AND METHODS: Elastase (25 mU) was injected into the cisterna magna in C57BL/6J (n = 36) and 129/SvEv (SV129) (n = 36) mice. Control animals were injected with heat-inactivated elastase (n = 12 for each strain). At 3, 7, 14, and 28 days after elastase injection, MICROFIL polymer perfusion was performed. The arterial tortuosity index and the percentage increase in diameter were calculated for the basilar artery. Arterial samples were processed for conventional histologic examination, immunostaining, and matrix metalloproteinase expression. A ≥50% increase in diameter and a tortuosity index of ≥10 for the basilar artery were used to indicate success in achieving vertebrobasilar dolichoectasia. RESULTS: Successful vertebrobasilar dolichoectasia induction was noted in 67% (18 of 27) of the C57BL/6J strain versus 0% (0 of 19) of the SV129 strain (P < .001). Vertebrobasilar dolichoectasia was not observed in sham-operated controls. Both the tortuosity index and diameter increase for the basilar artery were greater in the C57BL/6J strain compared with the SV129 strain (56.3% ± 16.4% versus 21.1% ± 21.6% for diameter, P < .001; 17.4 ± 7.6 versus 10.4 ± 3.8 for tortuosity index, P < .001). Expression of pro-matrix metalloproteinase-2 and pro- and active matrix metalloproteinase-9 was increased in elastase-injected C57BL/6J animals compared with elastase-injected SV129 animals (P = .029, 0.029, and 0.029, respectively). Inflammation scores were significantly higher in C57BL/6J animals versus SV129 animals (P < .001). C57BL/6J subjects demonstrated arterial wall dilation and elongation characterized by internal elastic lamina disruption, muscular layer discontinuity, inflammatory cell infiltration, and high matrix metalloproteinase expression in the media. CONCLUSIONS: C57BL/6J mice demonstrated greater susceptibility to vertebrobasilar dolichoectasia induction than SV129 mice.
End-product quality characteristics and consumer response of chickpea flour-based gluten-free muffins containing corn starch and egg white.

The objective of this work was to study changes in technological characteristics and sensory properties of gluten-free muffins when using chickpea flour (CF) alone and/or with partial CF replacement by corn starch (CS). The effect of partial whole egg replacement by egg white (EW) was also investigated. Four different CF:CS ratios (100:0, 75:25, 50:50, and 25:75) were used in formulations with and without incorporated EW, and compared with wheat flour (WF) muffins (0:0). Muffins prepared from CF alone had lower hardness, springiness, cohesiveness, chewiness, and resilience than control ones. However, reducing protein content by CS addition significantly increased texture profile analysis parameters of muffin crumb. Muffins prepared with 25:75 ratio had a structure with springiness similar to muffins made with WF but were too hard. Reducing whole egg content by partial replacement with EW also significantly increased muffin hardness. Flash profile performed by consumers showed a clear discrimination of muffins according to CF:CS ratio. Muffins containing both CF and CS at 50:50 ratio had the same high overall acceptability and purchase intention as gluten ones. Gluten-free CF-based muffins of satisfactory quality can be manufactured by CS incorporation, either with or without EW. PRACTICAL APPLICATIONS By decreasing and increasing protein and starch contents of chickpea flour (CF) by incorporation of corn starch (CS), muffins formulated from a combination of CF and CS at different CF:CS ratios, either with or without partial replacement of whole egg with egg white, result in high-quality muffins with similar technological and sensory characteristics to those of their gluten counterparts. Sensory overall acceptability and purchase intention of muffins made with a 50:50 ratio did not differ significantly from those of the controls. These findings will benefit celiac population, while promoting the value and utilization of pulses through muffins.
Arytenoid adduction asymmetries in persons with and without voice disorders

Asymmetry of the arytenoid complex is considered when evaluating a patient for a voice disorder. This study sought to determine if there were differences in arytenoid adduction asymmetry in persons with and without voice disorders. Three aspects of arytenoid adduction asymmetry were judged from still frames of the arytenoids in the adducted position from stroboscopy recordings of 52 vocally normal speakers and 54 persons with voice disorders. Asymmetry of the arytenoids was prevalent in both normophonic and dysphonic speakers. The lack of strong differences in the prevalence of arytenoid asymmetries in the adducted position between normophonic and dysphonic speakers suggests that caution should be taken when using these asymmetries as indicator of or related to a voice disorder.
Retinoprotective effects of Moringa oleifera via antioxidant, anti-inflammatory, and anti-angiogenic mechanisms in streptozotocin-induced diabetic rats.

PURPOSE The present study was aimed to evaluate the retinoprotective effects of Moringa oleifera (MO) in Streptozotocin-induced diabetic rats. METHODS The study was continued for 24 weeks and evaluated for inflammatory (tumor necrosis factor [TNF]-α and interleukin [IL]-1β, angiogenic (vascular endothelial growth factor [VEGF] and protein kinase C [PKC]-β) and antioxidant (Glutathione, Superoxide dismutase, and Catalase) parameters. Retinal leakage was checked by Fluorescein angiography (FA) and fundus photographs were evaluated for retinal vessel caliber (arteriolar and venular). Transmission electron microscopy was done to determine basement membrane (BM) thickness. RESULTS The results of the present study showed potential hypoglycemic and retinal antioxidant effects of MO. In the present study, a significant rise in the expression of retinal inflammatory (TNF-α and IL-1β) and angiogenic (VEGF and PKC-β) parameters was observed in diabetic retinae as compared to normal retinae. However, MO-treated retinae showed marked inhibition in the expression of inflammatory and angiogenic parameters. Further, in the present study, diabetic retinae showed dilated retinal vessels as compared to normal. However, MO-treated retinae showed marked prevention in the dilatation of retinal vessels. Fluorescein angiograms obtained from diabetic retinae showed leaky and diffused retinal vasculature. On the other hand, MO-treated retinae showed intact retinal vasculature. Further, results of the transmission electron microscopy study showed thickened capillary BM in the diabetic retina as compared to normal retinae. However, treatment with MO prevented thickening of capillary BM. CONCLUSION Our result suggests that MO may be useful in preventing diabetes induced retinal dysfunction.
Ontology-based Text Document Clustering

Text clustering typically involves clustering in a high dimensional space, which appears difficult with regard to virtually all practical settings. In addition, given a particular clustering result it is typically very hard to come up with a good explanation of why the text clusters have been constructed the way they are. In this paper, we propose a new approach for applying background knowledge during preprocessing in order to improve clustering results and allow for selection between results. We preprocess our input data applying an ontology-based heuristics for feature selection and feature aggregation. Thus, we construct a number of alternative text representations. Based on these representations, we compute multiple clustering results using KMeans. The results may be distinguished and explained by the corresponding selection of concepts in the ontology. Our results compare favourably with a sophisticated baseline preprocessing strategy.
Endothelial permeability and VE-cadherin

The endothelium forms a selective semi-permeable barrier controlling bidirectional transfer between blood vessel and irrigated tissues. This crucial function relies on the dynamic architecture of endothelial cell–cell junctions, and in particular, VE-cadherin-mediated contacts. VE-cadherin indeed chiefly organizes the opening and closing of the endothelial barrier, and is central in permeability changes. In this review, the way VE-cadherin-based contacts are formed and maintained is first presented, including molecular traits of its expression, partners, and signaling. In a second part, the mechanisms by which VE-cadherin adhesion can be disrupted, leading to cell–cell junction weakening and endothelial permeability increase, are described. Overall, the molecular basis for VE-cadherin control of the endothelial barrier function is of high interest for biomedical research, as vascular leakage is observed in many pathological conditions and human diseases.
Endoscopic Laryngeal Findings in Japanese Patients with Laryngopharyngeal Reflux Symptoms

Objective. To know the characteristics of endoscopic laryngeal and pharyngeal abnormalities in Japanese patients with laryngopharyngeal reflux symptoms (LPRS). Methods. A total of 146 endoscopic images of the larynx and pharynx (60 pairs for the rabeprazole group and 13 pairs for the control group) were presented to 15 otolaryngologists blinded to patient information and were scored according to several variables potentially associated with laryngopharyngeal reflux. The median value of the 15 scores for each item from each image was obtained. The mean pretreatment scores of each item and total score were assessed in both rabeprazole and control groups. In the rabeprazole group, the endoscopic findings before and after the 4-week treatment with rabeprazole were compared. Changes between corresponding duration in the control group were also evaluated. Results. The median and mean pretreatment total score was 3 and 3.02, respectively, from the 73 patients with LPRS. No significant differences were observed before and after treatment in either the rabeprazole or control groups for any item or total score. In 24 patients with a high pretreatment score (total score ≥ 4) from the rabeprazole group, significant decreases in scores for “thick endolaryngeal mucous” (0.54 to 0.17, P = 0.017) and total (4.77 to 3.58, P = 0.0003) were observed after the 4-week treatment.
The triangular stress diagram; a graphical representation of crustal stress measurements

A new graphical method is introduced that facilitates the representation and interpretation of the generally anisotropic in situ states-ofstress measured in rocks. The purpose of the method is to clearly and easily display these stress states, each measured in terms of three values, in two-dimensional space; this is done by projecting three-dimensional stress space onto a triangular-coordinate (ternary) diagram and plotting the measured stress states as points. Failure surfaces determined either by experiment or by invoking hypothetical failure criteria are plotted on the diagram to enclose the stability field. Thus, an anisotropic stress condition measured at a given depth in the Earth's crust is represented by a single point on the triangular diagram and its relative position in the enclosed stress space may yield useful information on the degree of mechanical stability of the rock mass at the point of measurement. The method also allows the representation of any number of measured stress states in a given locality, each plotted in its own position. This method is most useful as a reconnaissance tool, provided complete measurements of in situ stress as a function of depth are available, to correlate them with information obtained by different, more indirect methods. A variety of stress paths either associated with the measured stress-depth distribution, or modified by fluid injection or mined excavations, among others, can be traced or extrapolated to establish whether the imposed disturbance leads to failure of crustal rocks.
Electrospun Nanocellulose: A New Biomaterial

Science and engineering studies on biocompatible implantable materials for tissue and organ repair have recently focused on polymeric materials to serve as scaffolds for cellular integration. Cellulose in many forms has been demonstrated as potential biopolymer for tissue engineering; however, it has not been previously electrospun into a scaffold for tissue engineering applications. The overall goal of this research project was to produce electrospun cellulose acetate (CA) nanofibers with specific architectures and surface chemistries to be evaluated as scaffolds for tissue regeneration. The size and morphology of electrospun CA was impacted by polymer concentration, solvent system, and solution flow rate. The conversion of CA electrospun scaffolds into regenerated cellulose by exposure to NaOH ethanol solution was successful for scaffolds produced at polymer solution flow rate of at least 1 mL/h. The regeneration process resulted in minimal degradation of the cellulose while retaining the original fiber structure of the scaffold. In vitro cytotoxicity evaluation of the fibrous cellulose scaffolds on a culture of mouse fibroblast (L-929) cells indicated that this material posed no threat to mammalian cells. Electrospun cellulose scaffolds with different architectures and surface chemistries were designed and evaluated to enhance scaffold properties and cell adhesion. The morphology of the partially regenerated cellulose revealed only a broad diffraction peak for the scaffold material, while the fully regenerated cellulose showed a characteristic semi-crystalline cellulose II diffraction pattern. Fiber orientation and porosity of the scaffolds were controlled by electrospining CA solution onto the edge of a rotator wheel and laser microablation, respectively. Bioactivity of the scaffolds was shown to be enhanced via scaffold surface modification with either anionic or cationic functional groups. Biomimetic Ca-P crystal mineralization on electrospun cellulose fibers was produced by means of carboxymethyl cellulose (CMC) adsorption and treatments with simulated body fluid (SBF) or phosphate buffer saline (PBS) solutions. Porosity and Ca-P crystals enhanced osteoprogenitor cell adhesion on the electrospun cellulose scaffolds. Cationic modification by trimethyl ammonium betahydroxy propyl (THAMP) derivation and adsorption of extracellular matrix proteins on cellulose fibers promoted adhesion and proliferation of neural-like (PC12) and myoblast (C2C12) cells. Differentiation of myoblast cells (C2C12) towards myotubes on electrospun cellulose scaffolds was controlled by surface chemistry and mechanical properties. Together these studies showed great potential for cellulose acetate to be electrospun and converted into a viable biocompatible tissue engineering scaffolds.
A PZT Actuated Triple-Finger Gripper for Multi-Target Micromanipulation

This paper presents a triple-finger gripper driven by a piezoceramic (PZT) transducer for multi-target micromanipulation. The gripper consists of three fingers assembled on adjustable pedestals with flexible hinges for a large adjustable range. Each finger has a PZT actuator, an amplifying structure, and a changeable end effector. The moving trajectories of single and double fingers were calculated and finite element analyses were performed to verify the reliability of the structures. In the gripping experiment, various end effectors of the fingers such as tungsten probes and fibers were tested, and different micro-objects such as glass hollow spheres and iron spheres with diameters ranging from 10 to 800 μm were picked and released. The output resolution is 145 nm/V, and the driven displacement range of the gripper is 43.4 μm. The PZT actuated triple-finger gripper has superior adaptability, high efficiency, and a low cost.
Delayed Recognition of HIV Infection in Malnourished Children Is Associated With Poor Clinical Outcome in Low HIV Prevalence Settings Preliminary Observations

To the Editor: Infection with HIV-2, the second causative etiology for AIDS, is mainly present in West Africa, with a slow spread to other continents. Compared with HIV-1 infection, the course of HIV2 infection is associated with slower progression to AIDS, most likely attributable to lower plasma viral loads observed in these patients. In dual-infected patients, control of HIV-1 may be associated with the ability to respond to HIV-2 gag epitopes and to maintain HIV-specific CD4 T-cell responses. We recently tested a small group of long-term nonprogressors with HIV-1 infection (elite suppressors) to rule out coinfection with HIV-2. Three of 13 patients underwent testing with an HIV-2 enzyme immunoassay (EIA), and all 13 had HIV-2 Immunoblots performed at VircoMed Laboratories/Laboratory Corporation of America (Minnetonka, MN). One of the 13 patients had a significant HIV-2 risk factor with a previous sexual partner from West Africa of unknown HIV status. Using the commercially available assays, specimens were considered positive for the HIV-2 Immunoblot test if the gp36 band (env) was present. All patients tested positive with the HIV-2 EIA and the HIV-2 Immunoblot (of whom 2 were weakly positive). When HIV-2 qualitative polymerase chain reaction (PCR) tests were performed, all patients were negative, thus ruling out coinfection with HIV-2. Although previous studies have reported high sensitivity (91% to 100%) and specificity (81% to 100%) for HIV-2 antibody testing, this may become more challenging in coinfected patients because of cross-reactivity. The 2 viruses have similar morphology and cell tropism, with homology exhibited in the conserved genes, such as the core proteins (gag) and reverse transcriptase (pol), and in other less conserved envelope (env) genes. Although qualitative PCR testing is available at reference laboratories, quantitative viral loads are not available except in research facilities. Given the high false-positivity rate of the commercially available assays because of cross-reactivity with HIV-1, serologic testing for HIV-2 infection should be used only in patients with negative HIV-1 Western blot test results in areas in which HIV-2 is not endemic. In cases when dual infection is suspected, our recommendation would be to proceed directly to HIV-2 PCR testing.
Controlling active site loop dynamics in the (β/α)8 barrel enzyme indole-3-glycerol phosphate synthase

The β1α1 loop in the tryptophan biosynthetic enzyme indole-3-glycerol phosphate synthase (IGPS) is important for substrate binding, product release and chemical catalysis. IGPS catalyzes the ring closure of the substrate 1-(o-carboxyphenylamine)-1-dexoyribulose 5-phosphate to form indole-3-glycerol phosphate, involving distinct decarboxylation and dehydration steps. The ring closure step is rate-determining in the thermophilic Sulfolobus sulfataricus enzyme (ssIGPS) at high temperatures. The β1α1 loop is especially important in the dehydration step as it houses the general acid Lys53. We propose that loop dynamics are governed by competing interactions on the N- and C-terminal sides of the loop. We had previously shown that disrupting interactions with the N-terminal side of the loop through the N90A substitution decreases catalytic efficiency, slows down the dehydration step and quenches loop dynamics on the picosecond to millisecond timescales. Here, we show that disrupting interactions on the C-terminal side of the loop through the R64A/D65A substitutions likewise decreases catalytic efficiency, slows down the dehydration step and quenches loop dynamics. Interestingly, the triple substitution R64A/D65A/N90A leads to new μs–ms timescale loop dynamics and makes the ring-closure step rate-determining once again. These results are consistent with a model in which the β1α1 loop is maintained in a structurally dynamic state by these competing interactions, which is important for the dehydration step of catalysis. Competing interactions in other enzymes may likewise keep their loops and other structural elements appropriately mobile.