Miracle-dz/UniFAR-FTUs huggingface dataset:
Pharmacokinetics and tolerability of eletriptan hydrobromide in healthy Korean subjects

Background Migraine is one of the most common headache disorders that greatly affect the quality of life. Selective serotonin (5-HT) receptor agonists such as triptamine-based drugs called triptans are used for treatment of migraine. Purpose This study aimed to evaluate the pharmacokinetic (PK) and tolerability profiles of eletriptan hydrobromide (eletriptan HBr), a selective 5-hydroxytryptamine (also known as serotonin) 1B/1D receptor agonist, in Koreans and compare the results to those observed in non-Koreans in a previously published study. Patients and methods A randomized, open-label, single, and repeated-dose study was conducted in 16 healthy Korean male subjects using a four-treatment, four-period, and four-sequence crossover design (NCT01139515). The subjects received one of the following four treatments in each period: a single dose of 20, 40, 80 mg eletriptan HBr or a repeated oral dose of 40 mg 2 h apart. Blood samples were collected before and up to 26 h after dosing for quantification of plasma eletriptan concentration by high-performance liquid chromatography tandem–mass spectrometry. The PK parameters were estimated using noncompartmental methods. Ethnicity differences between Korean and non-Korean subjects were identified using geometric mean ratios and 90% confidence intervals (CIs) of dose-normalized maximum plasma concentration (Cmax) and dose-normalized area under the plasma concentration versus time curve from 0 h to the last measurable concentration (AUC0–t). Results After single-dose administration of eletriptan HBr to Korean subjects, the mean Cmax and AUC0–t increased linearly with dose. Comparable total systemic exposures were observed in the 2 h apart 40 mg repeated and single 80 mg dose. The geometric mean ratios (90% CIs) of the dose-normalized Cmax and AUC0–t of Korean subjects were similar to those of non-Korean subjects reported in the literature. The adverse events observed were transient and mild in severity. Conclusion Eletriptan HBr showed linear PK and was well tolerated in Korean subjects. The PK and tolerability of eletriptan HBr did not differ between Korean and non-Korean subjects.
A synopsis of the saddle fungi (Helvella: Ascomycota) in Europe – species delimitation, taxonomy and typification

Helvella is a widespread, speciose genus of large apothecial ascomycetes (Pezizomycete: Pezizales) that are found in terrestrial biomes of the Northern and Southern Hemispheres. This study represents a beginning on assessing species limits and applying correct names for Helvella species based on type material and specimens in the university herbaria (fungaria) of Copenhagen (C), Harvard (FH) and Oslo (O). We use morphology and phylogenetic evidence from four loci – heat shock protein 90 (hsp), translation elongation factor alpha (tef), RNA polymerase II (rpb2) and the nuclear large subunit ribosomal DNA (LSU) – to assess species boundaries in an expanded sample of Helvella specimens from Europe. We combine the morphological and phylogenetic information from 55 Helvella species from Europe with a small sample of Helvella species from other regions of the world. Little intraspecific variation was detected within the species using these molecular markers; hsp and rpb2 markers provided useful barcodes for species delimitation in this genus, while LSU provided more variable resolution among the pertinent species. We discuss typification issues and identify molecular characteristics for 55 European Helvella species, designate neo- and epitypes for 30 species, and describe seven Helvella species new to science, i.e., H. alpicola, H. alpina, H. carnosa, H. danica, H. nannfeldtii, H. pubescens and H. scyphoides.
Hyperplasia and hypertrophy of the chickens (Gallus domesticus) oviduct during a reproductive cycle.

Abstract The quantitative changes in hyperplasia and hypertrophy of chicken (Gallus domesticus) oviducts ranging in weight from 25 mg. to 51,000 mg. were compared throughout a reproductive cycle (developing, laying, and regressing stages). The average 3000 fold increase in dry oviduct weight from the 3-week old chick to the laying hen was attributed to a 600 fold increase in cell numbers (from 47 × 106 to 28,050 × 106) and to a 5-fold increase in dry mass per cell (from 60 pg. to 318 pg.). At the end of oviduct regression both cell numbers and cell mass decreased to 4540 × 106 and 105 pg. , respectively. The relative contribution of cell numbers and cell mass was also established at various oviduct weight intervals during the reproductive cycle. There were differential growth and regression patterns for the five regions of the oviduct during a reproductive cycle. The weight, cell numbers, and cell mass in the magnum and the isthmus increased more rapidly as compared with the other oviduct regions (infundibulum, uterus, and vagina) during the developing and laying stages. A similar but opposite pattern occurred during oviduct regression.
Erdős–Pósa property of obstructions to interval graphs

A class of graphs ℱ ${\rm{ {\mathcal F} }}$ admits the Erdős–Pósa property if for any graph G $G$ , either G $G$ has k $k$ vertex‐disjoint “copies” of the graphs in ℱ ${\rm{ {\mathcal F} }}$ , or there is a set S ⊆ V ( G ) $S\subseteq V(G)$ of f ( k ) $f(k)$ vertices that intersects all copies of the graphs in ℱ ${\rm{ {\mathcal F} }}$ . For any graph class G ${\mathscr{G}}$ , it is natural to ask whether the family of obstructions to G ${\mathscr{G}}$ has the Erdős–Pósa property. In this paper, we prove that the family of obstructions to interval graphs—namely, the family of chordless cycles and asteroidal witnesses (AWs)—admits the Erdős–Pósa property. In turn, this yields an algorithm to decide whether a given graph G $G$ has k $k$ vertex‐disjoint AWs and chordless cycles, or there exists a set of O ( k 2 log k ) ${\mathscr{O}}({k}^{2}\mathrm{log}k)$ vertices in G $G$ that hits all AWs and chordless cycles.
Public Provision of Private Goods, Tagging and Optimal Income Taxation with Heterogeneity in Needs

Previous literature has shown that public provision of private goods can be a welfare-enhancing device in second-best settings where governments pursue redistributive goals. However, three issues have so far been neglected. First, the case for supplementing an optimal nonlinear income tax with public provision of private goods has been made in models where agents differ only in terms of market ability. Second, the magnitude of the welfare gains achievable through public provision schemes has not been assessed. Third, the similarities/differences between public provision schemes and tagging schemes have not been thoroughly analyzed. Our purpose in this paper is therefore threefold: first, to extend previous contributions by incorporating in the theoretical analysis both heterogeneity in market ability and in the need for the publicly provided good; second, to perform numerical simulations to quantify the size of the potential welfare gains achievable by introducing a public provision scheme, and to characterize the conditions under which these welfare gains are sizeable; finally, to compare the welfare gains from public provision with the welfare gains from tagging.
Exploration of avocado by-products as natural sources of bioactive compounds

This study aimed to evaluate the antioxidant, anti-inflammatory, and cytotoxic properties and phenolic composition of peel and seed of avocado varieties Hass and Fuerte using green solvents. Ethanol soluble compounds were identified in peel and seed of both varieties using HPLC-MS/MS and quantified using HPLC-DAD. Agro-industrial by-products of both varieties exhibited high radical scavenging activity against synthetic free radicals (DPPH and ABTS) and reactive oxygen species (peroxyl, superoxide, and hypochlorous acid) and high ability to reduce Fe3+ to Fe2+. The main compounds with significant contribution to the antioxidant activity determined by online HPLC-ABTS●+ analyses were procyanidin B2 and epicatechin in the peel and trans-5-O-caffeoyl-D-quinic acid, procyanidin B1, catechin, and epicatechin in the seed. Peel of Fuerte significantly suppressed TNF-α and nitric oxide (NO) release (459.3 pg/mL and 8.5 μM, respectively), possibly because of the high phenolic content and antioxidant activity detected. Avocado agro-industrial by-products can be used for food and pharmaceutical purposes due to their antioxidant and anti-inflammatory properties.
FLIP-Q: A QCIF Resolution Focal-Plane Array for Low-Power Image Processing

This paper reports a 176×144-pixel smart image sensor designed and fabricated in a 0.35 CMOS-OPTO process. The chip implements a massively parallel focal-plane processing array which can output different simplified representations of the scene at very low power. The array is composed of pixel-level processing elements which carry out analog image processing concurrently with photosensing. These processing elements can be grouped into fully-programmable rectangular-shape areas by loading the appropriate interconnection patterns into the registers at the edge of the array. The targeted processing can be thus performed block-wise. Readout is done pixel-by-pixel in a random access fashion. On-chip 8b ADC is provided. The image processing primitives implemented by the chip, experimentally tested and fully functional, are scale space and Gaussian pyramid generation, fully-programmable multiresolution scene representation-including foveation-and block-wise energy-based scene representation. The power consumption associated to the capture, processing and A/D conversion of an image flow at 30 fps, with full-frame processing but reduced frame size output, ranges from 2.7 mW to 5.6 mW, depending on the operation to be performed.
Modified extraction 2-thiobarbituric acid method for measuring lipid oxidation in poultry.

A simple and accurate objective test for monitoring lipid oxidation in poultry products is needed. Thiobarbituric acid (TBA) values of cooked poultry meat were determined by a distillation method and by a modified extraction method. Perchloric acid was used in the extraction method to release TBA reactive substances from the meat. The maximum absorption wavelength of the TBA-malonaldehyde complex was 531 nm. The TBA values for cooked chicken and turkey were highly correlated (r = .91) for both the extraction and distillation methods. Sensory scores of warmed-over flavor in precooked poultry were highly correlated with TBA values in both the distillation (r = .83) and extraction (r = .85) methods. Results indicate that the extraction method is faster, easier to perform, and as accurate as the distillation method for monitoring lipid oxidation in poultry.
Responses to Interpersonal Stress: Normative Changes Across Childhood and the Impact of Peer Victimization.

This research examined the development of stress responses across second to sixth grades and whether exposure to peer victimization alters stress response trajectories. Youth (338 girls; 298 boys; Mage = 7.97 years, SD = .37) reported on stress responses; teachers and youth reported on peer victimization. Latent growth curve modeling revealed an increase in effortful engagement responses and a decrease in disengagement and involuntary engagement responses during this period. Peer victimization disrupted these normative trajectories, resulting in less effortful engagement and more effortful disengagement and involuntary stress responses in early adolescence. These findings suggest that early peer victimization sensitizes youth to stress by interfering with the development of effective coping and fostering maladaptive stress responses.
Changes in phytochemical contents in different parts of Clinacanthus nutans (Burm. f.) lindau due to storage duration

Clinacanthus nutans is a well recognized medicinal herb for its high phytochemical contents. Several aspects may contribute to the phytochemical contents, and thus determine the quality and efficacy of an herb. An experiment was conducted using a completely randomized design (CRD) with five replications, in a factorial arrangement of treatments. including two plant parts harvested at two different stages such as young leaves, young stems, matured leaves and matured stems, and four different storage durations such as 1, 2, 3 and 4 days. The study was aimed at determining how storage duration affects selected phytochemical contents of different plant parts of C. nutans at different harvesting stages. Total phytochemical content, total flavonoids content and DPPH radical scavenging activities are higher in young plants than in old plants, moreover, all those compounds are higher in leaves than in stems, and decrease gradually due to storage. Phytochemical, ascorbic acid and chlorophyll content of C. nutans differ among different plant parts and change due to storage. In general, young plant parts contain higher amount of phytochemicals, ascorbic acid and chlorophyll compared with matured parts confirming that phytochemicals content of C. nutans decreases when plants tend to maturity. Prolonged storage reduces phytochemical, ascorbic acid and chlorophyll content of C. nutans,which demands fresh use of this medicinal herb to avoid phytochemical losses. Further research focusing on the proper storage is necessary to minimize phytochemicals losses of C. nutans.
Dynamic finite-strain modelling of the human left ventricle in health and disease using an immersed boundary-finite element method

Detailed models of the biomechanics of the heart are important both for developing improved interventions for patients with heart disease and also for patient risk stratification and treatment planning. For instance, stress distributions in the heart affect cardiac remodelling, but such distributions are not presently accessible in patients. Biomechanical models of the heart offer detailed three-dimensional deformation, stress and strain fields that can supplement conventional clinical data. In this work, we introduce dynamic computational models of the human left ventricle (LV) that are derived from clinical imaging data obtained from a healthy subject and from a patient with a myocardial infarction (MI). Both models incorporate a detailed invariant-based orthotropic description of the passive elasticity of the ventricular myocardium along with a detailed biophysical model of active tension generation in the ventricular muscle. These constitutive models are employed within a dynamic simulation framework that accounts for the inertia of the ventricular muscle and the blood that is based on an immersed boundary (IB) method with a finite element description of the structural mechanics. The geometry of the models is based on data obtained non-invasively by cardiac magnetic resonance (CMR). CMR imaging data are also used to estimate the parameters of the passive and active constitutive models, which are determined so that the simulated end-diastolic and end-systolic volumes agree with the corresponding volumes determined from the CMR imaging studies. Using these models, we simulate LV dynamics from enddiastole to end-systole. The results of our simulations are shown to be in good agreement with subject-specific CMR-derived strain measurements and also with earlier clinical studies on human LV strain distributions.
Let's Dance: Learning From Online Dance Videos

In recent years, deep neural network approaches have naturally extended to the video domain, in their simplest case by aggregating per-frame classifications as a baseline for action recognition. A majority of the work in this area extends from the imaging domain, leading to visual-feature heavy approaches on temporal data. To address this issue we introduce "Let's Dance", a 1000 video dataset (and growing) comprised of 10 visually overlapping dance categories that require motion for their classification. We stress the important of human motion as a key distinguisher in our work given that, as we show in this work, visual information is not sufficient to classify motion-heavy categories. We compare our datasets' performance using imaging techniques with UCF-101 and demonstrate this inherent difficulty. We present a comparison of numerous state-of-the-art techniques on our dataset using three different representations (video, optical flow and multi-person pose data) in order to analyze these approaches. We discuss the motion parameterization of each of them and their value in learning to categorize online dance videos. Lastly, we release this dataset (and its three representations) for the research community to use.
Filtering Variational Objectives

When used as a surrogate objective for maximum likelihood estimation in latent variable models, the evidence lower bound (ELBO) produces state-of-the-art results. Inspired by this, we consider the extension of the ELBO to a family of lower bounds defined by a particle filter's estimator of the marginal likelihood, the filtering variational objectives (FIVOs). FIVOs take the same arguments as the ELBO, but can exploit a model's sequential structure to form tighter bounds. We present results that relate the tightness of FIVO's bound to the variance of the particle filter's estimator by considering the generic case of bounds defined as log-transformed likelihood estimators. Experimentally, we show that training with FIVO results in substantial improvements over training the same model architecture with the ELBO on sequential data.
Resistance of Lasioderma serricorne (Coleoptera: Anobiidae) to Fumigation with Phosphine

ABSTRACT Lasioderma serricorne (F.) is a serious pest of stored products that is known to be resistant to the fumigant pesticide gas phosphine. This study investigated resistance in populations from the southeastern United States, and determined if a recommended treatment schedule could kill resistant insects. A laboratory assay for adult insects was developed that used a discriminating concentration of 50 ppm phosphine applied to insects for 20 h at 25°C followed by 7 d of recovery in air. Survivors were classified as resistant. L. serricorne from six different field populations associated with stored tobacco were surveyed with the assay and all had resistant individuals. Four populations had greater than 90% of their insects resistant. Two industry-recommended treatment schedules were evaluated in laboratory fumigations against mixed life stage cultures of the four most resistant populations: the first at 200 ppm for 4 d at 25°C for controlling phosphine-susceptible L. serricorne and the second at 600 ppm for 6 d at 25°C intended to control phosphine-resistant beetles. The four populations with the highest frequency of resistant individuals from the field sampling study were not controlled by the “normal” treatment intended for susceptible insects. The higher concentration treatment greatly reduced beetle progeny from mixedstage colony jars, but there were substantial numbers of surviving adults from all four highly resistant populations that represented unacceptable levels of control.
Tolerance and Excretion of the Mycotoxins Aflatoxin B1, Zearalenone, Deoxynivalenol, and Ochratoxin A by Alphitobius diaperinus and Hermetia illucens from Contaminated Substrates

This study aimed to investigate the potential accumulation of mycotoxins in the lesser mealworm (Alphitobius diaperinus, LMW) and black soldier fly (Hermetia illucens, BSF) larvae. Feed was spiked with aflatoxin B1, deoxynivalenol (DON), ochratoxin A or zearalenone, and as a mixture of mycotoxins, to concentrations of 1, 10, and 25 times the maximum limits set by the European Commission for complete feed. This maximum limit is 0.02 mg/kg for aflatoxin B1, 5 mg/kg for DON, 0.5 mg/kg for zearalenone and 0.1 mg/kg for ochratoxin A. The mycotoxins and some of their metabolites were analysed in the larvae and residual material using a validated and accredited LC-MS/MS-based method. Metabolites considered were aflatoxicol, aflatoxin P1, aflatoxin Q1, and aflatoxin M1, 3-acetyl-DON, 15-acetyl-DON and DON-3-glycoside, and α- and β-zearalenol. No differences were observed between larvae reared on mycotoxins individually or as a mixture with regards to both larvae development and mycotoxin accumulation/excretion. None of the mycotoxins accumulated in the larvae and were only detected in BSF larvae several orders of magnitude lower than the concentration in feed. Mass balance calculations showed that BSF and LMW larvae metabolized the four mycotoxins to different extents. Metabolites accounted for minimal amounts of the mass balance, except for zearalenone metabolites in the BSF treatments, which accounted for an average maximum of 86% of the overall mass balance. Both insect species showed to excrete or metabolize the four mycotoxins present in their feed. Hence, safe limits for these mycotoxins in substrates to be used for these two insect species possibly could be higher than for production animals. However, additional analytical and toxicological research to fully understand the safe limits of mycotoxins in insect feed, and thus the safety of the insects, is required.
Birth and Adoptive Parent Antisocial Behavior and Parenting: A Study of Evocative Gene-Environment Correlation.

Negative parenting is shaped by the genetically influenced characteristics of children (via evocative rGE) and by parental antisocial behavior; however, it is unclear how these factors jointly impact parenting. This study examined the effects of birth parent and adoptive parent antisocial behavior on negative parenting. Participants included 546 families within a prospective adoption study. Adoptive parent antisocial behavior emerged as a small but significant predictor of negative parenting at 18 months and of change in parenting from 18 to 27 months. Birth parent antisocial behavior predicted change in adoptive father's (but not mother's) parenting over time. These findings highlight the role of parent characteristics and suggest that evocative rGE effects on parenting may be small in magnitude in early childhood.
Trade Flows and Fiscal Multipliers

Abstract We present novel insights on the role of international trade following unanticipated fiscal changes in a flexible exchange rate environment. We show analytically that fiscal multipliers can be larger in economies more open to trade, even when fiscal expansions imply trade deficits. Three factors determine how trade linkages matter: the relative import share of public and private goods, the financing of government debt, and the currency invoicing of exports. A Bayesian prior-predictive analysis shows that a quantitative model bears the same predictions. Conditioning on Canadian and U.S. data, we find support for larger multipliers relative to a counterfactually closed economy.
Sibling relationship quality and Mexican-origin adolescents’ and young adults’ familism values and adjustment

We examined profiles of sibling relationship qualities in 246 Mexican-origin families living in the United States using latent profile analyses. Three profiles were identified: Positive, Negative, and Affect-Intense. Links between profiles and youths’ familism values and adjustment were assessed using longitudinal data. Siblings in the Positive profile reported the highest familism values, followed by siblings in the Affect-Intense profile and, finally, siblings in the Negative profile. Older siblings in the Positive and Affect-Intense profiles reported fewer depressive symptoms than siblings in the Negative profile. Further, in the Positive and Negative profiles, older siblings reported less involvement in risky behaviors than younger siblings. In the Negative profile, younger siblings reported greater sexual risk behaviors in late adolescence than older siblings; siblings in opposite-sex dyads, as compared to same-sex dyads, engaged in riskier sexual behaviors. Our findings highlight sibling relationship quality as promotive and risky, depending on sibling characteristics and adjustment outcomes.