Miracle-dz/UniFAR-FTUs huggingface dataset:
Truly online paging with locality of reference

The access graph model for paging, defined by (Borodin et al., 1991) and studied in (Irani et al., 1992) has a number of troubling aspects. The access graph has to be known in advance to the paging algorithm and the memory required to represent the access graph itself may be very large. We present a truly online strongly competitive paging algorithm in the access graph model that does not have any prior information on the access sequence. We give both strongly competitive deterministic and strongly competitive randomized algorithms. Our algorithms need only O(k log n) bits of memory, where k is the number of page slots available and n is the size of the virtual address space, i.e., no more memory than needed to store the virtual translation tables for pages in memory. In fact, we can reduce this to O(k log k) bits using appropriate probabilistic data structures. We also extend the locality of reference concept captured by the access graph model to allow changes in the behavior of the underlying process. We formalize this by introducing the concept of an "extended access graph". We consider a graph parameter /spl Delta/ that captures the degree of change allowed. We study this new model and give algorithms that are strongly competitive for the (unknown) extended access graph. We can do so for almost all values of /spl Delta/ for which it is possible.
LOCAL BOND-STRESS TO SLIP RELATIONSHIPS FOR HOT ROLLED DEFORMED BARS AND MILD STEEL PLAIN BARS

A large number of tests were carried out to determine statistically reliable bond-stress to slip relations for 16 mm diameter hot rolled deformed bars and mild steel plain bars; two concrete covers, two directions of bar pull relative to the settlement of concrete, and different magnitudes of bar back load were used. A concrete embedment length of 38 mm or four times the deformed bar lug spacing was chosen. A considerable scatter was observed to slip curves and this confirms the necessity of statistically designed experiments. The maximum bond stress was not found to be significantly affected by the magnitude of the bar back load, but nevertheless it increased with increasing concrete cover and increased to a lesser extent when the bar was pulled in the opposite direction to that of casting as compared to pulling it in the same direction. /Author/
An estimation of critical buckling strain for pipe subjected plastic bending

An approach for estimating critical buckling strain of pipe subjected plastic bending is established in the present paper. A rigid — perfectly plastic material model and cross section ovalization of pipe during bending are employed for the approach. The energy rates of the ovalised pipe bending and the cross section ovalising are proposed firstly. Furthermore, these energy rates are combined to perform the buckling analysis of pipe bending, an estimation formula of critical buckling strain for pipe subjected plastic bending is proposed. The predicting result of the new critical buckling strain formula is compared with the available experimental data, it shows that the formula is valid.
Herpes Simplex Virus 1 ICP22 but Not US1.5 Is Required for Efficient Acute Replication in Mice and VICE Domain Formation

ABSTRACT The herpes simplex virus 1 (HSV-1) immediate-early protein, infected cell protein 22 (ICP22), is required for efficient replication in restrictive cells, for virus-induced chaperone-enriched (VICE) domain formation, and for normal expression of a subset of viral late proteins. Additionally, ICP22 is important for optimal acute viral replication in vivo. Previous studies have shown that the US1 gene that encodes ICP22, produces an in-frame, N-terminally truncated form of ICP22, known as US1.5. To date, studies conducted to characterize the functions of ICP22 have not separated its functions from those of US1.5. To determine the individual roles of ICP22 and US1.5, we made viral mutants that express either ICP22 with an M90A mutation in the US1.5 initiation codon (M90A) or US1.5 with three stop codons introduced upstream of the US1.5 start codon (3×stop). Our studies showed that, in contrast to M90A, 3×stop was unable to replicate efficiently in the eyes and trigeminal ganglia of mice during acute infection, to efficiently establish a latent infection, or to induce VICE domain formation and was only mildly reduced in its replication in restrictive HEL-299 cells and murine embryonic fibroblasts (MEFs). Both mutants enhanced the expression of the late viral proteins virion host shutoff (vhs) and glycoprotein C (gC) and inhibited viral gene expression mediated by HSV-1 infected cell protein 0 (ICP0). When we tested our mutants' sensitivity to type I interferon (beta interferon [IFN-β]) in restrictive cells, we noticed that the plating of the ICP22 null (d22) and 3×stop mutants was reduced by the addition of IFN-β. Overall, our data suggest that US1.5 partially complements the functions of ICP22.
Clinical significance of pAkt and pErk1/2 expression in early-stage breast cancer patients treated with anthracycline-based adjuvant chemotherapy

The expression of phosphorylated Akt (pAkt) and phosphorylated extracellular-regulated kinase 1/2 (pErk1/2) proteins may result in breast cancer progression and drug resistance in vitro, however, compelling evidence regarding the clinical significance of pAkt and pErk1/2 in early-stage breast cancer is currently lacking. Thus, the aim of the present study was to determine the prognostic value of pAkt and pErk1/2 expression in early-stage breast cancer patients treated with anthracycline-based adjuvant chemotherapy. Tumor specimens were obtained from 256 patients with early-stage breast cancer who had been treated with anthracycline-based adjuvant chemotherapy, and pAkt and pErk1/2 protein expression was immunohistochemically determined. The interactions between pAkt, pErk1/2 and clinical characteristics were assessed by performing χ2 tests, and survival functions were estimated using the Kaplan-Meier method. It was identified that pAkt and pErk1/2 were expressed in 38.7 and 33.6% of patients, respectively, and that pAkt protein expression was correlated with pErk1/2 protein expression (P<0.001). In addition, after a median follow-up period of 52.5 months, the patients with pAkt- and pErk1/2-negative tumors experienced a significantly longer disease-free survival (DFS) time compared with pAkt- or pErk1/2-positive patients (P=0.028). pErk1/2 expression was associated with the decreased DFS time of the patients (P=0.049), and pAkt and pErk1/2 expression were associated with the decreased DFS time in human epidermal growth factor receptor (HER2)-positive patients (P=0.002). pErk1/2 expression was associated with chemotherapy resistance (P=0.016). Thus, the coexpression of pAkt and pErk1/2 was an independent factor for a poor prognosis in early-stage and HER2-positive breast cancer patients. By contrast, pErk1/2 expression alone may be a poor predictor for determining the efficacy of anthracycline-based chemotherapy.
Loss of p27 Expression Is Associated with Poor Prognosis in Stage I–II Pancreatic Cancer

Objective: p27 is a cyclin-dependent kinase inhibitor that prevents progression of the cell cycle from G1 phase. Postranscriptional loss of p27 correlates with poor prognosis in various solid tumors. In pancreatic cancer, the loss of p27 expression has been correlated with high tumor grade and advanced clinical stage, but data on its prognostic value are lacking. Method: In this retrospective study, the association between immunohistochemical p27 expression and prognosis was evaluated in 147 patients with pancreatic cancer using a commercial anti-Kip1/p27 monoclonal antibody. Result: p27 expression was generally low; in 103 of the 147 pancreatic cancer tumors examined, no nuclear staining was observed and in only 5 specimens did more than 50% of the nuclei stain, probably reflecting the aggressive nature of the disease. Loss of p27 expression was associated with poor prognosis in stage I–II pancreatic adenocarcinoma; the 5-year survival for p27 negative patients was 3.6% compared with 20% for p27-positive patients (p = 0.03). In a multivariate survival analysis in patients with stage I–II disease, p27 (HR 1.8) was a significant prognostic factor, independent of grade (RR 2.9). There was no association between p27 and other clinical variables. In conclusion, tissue expression of p27 is a significant predictor of 5-year survival in stage I–II pancreatic adenocarcinoma.
Reference-assisted chromosome assembly

One of the most difficult problems in modern genomics is the assembly of full-length chromosomes using next generation sequencing (NGS) data. To address this problem, we developed “reference-assisted chromosome assembly” (RACA), an algorithm to reliably order and orient sequence scaffolds generated by NGS and assemblers into longer chromosomal fragments using comparative genome information and paired-end reads. Evaluation of results using simulated and real genome assemblies indicates that our approach can substantially improve genomes generated by a wide variety of de novo assemblers if a good reference assembly of a closely related species and outgroup genomes are available. We used RACA to reconstruct 60 Tibetan antelope (Pantholops hodgsonii) chromosome fragments from 1,434 SOAPdenovo sequence scaffolds, of which 16 chromosome fragments were homologous to complete cattle chromosomes. Experimental validation by PCR showed that predictions made by RACA are highly accurate. Our results indicate that RACA will significantly facilitate the study of chromosome evolution and genome rearrangements for the large number of genomes being sequenced by NGS that do not have a genetic or physical map.
Does race-ethnicity moderate the relationship between CPAP adherence and functional outcomes of sleep in US veterans with obstructive sleep apnea syndrome?

BACKGROUND Little is known about the association of race-ethnicity and the relationship of continuous positive airway pressure (CPAP) adherence with functional outcomes of sleep in American samples with obstructive sleep apnea syndrome (OSAS). This retrospective study examines whether race-ethnicity moderates the relationship between CPAP adherence and functional outcomes of sleep in OSAS. METHODS Over 4 months, consecutive OSAS patients had CPAP data downloads and completed questionnaires (demographics, Functional Outcomes of Sleep Questionnaire [FOSQ], Epworth Sleepiness Scale [ESS], Insomnia Severity Index [ISI]) at the Miami VA sleep center. Medical diagnoses and polysomnography data were obtained from medical record. CPAP adherence was measured as mean daily hours of use. Hierarchical regression modeling was used to explore the differential impact of race-ethnicity and CPAP adherence on functional outcomes of sleep. RESULTS Two hundred twenty-seven veterans (93% male, age 59 ± 11 years) were included; 142 (63%) participants self-reported as white or Hispanic, and 85 participants (37%) as black. Hierarchical regression analyses failed to show main effects for race-ethnicity or CPAP use and FOSQ scores; however, the interaction of race-ethnicity with CPAP adherence was significantly associated with the total FOSQ (p = 0.04), Social (p = 0.02), and Intimacy (p = 0.01) subscale scores. For blacks, in adjusted analyses, CPAP adherence was positively associated with Social and Intimacy FOSQ subscales; however, no significant relationship was noted between CPAP use and FOSQ scores in whites/Hispanics. CONCLUSIONS Race-ethnicity may moderate the relationship between CPAP adherence and some functional outcomes of sleep; however, further studies are needed.
High-Resolution Measurement of Resonant Wave Patterns by Perturbing the Evanescent Field Using a Nanosized Probe in a Transmission Scanning Near-Field Optical Microscopy Configuration

In order to model transmission scanning near-field optical microscopy (T-SNOM) experiments, we study the interaction between a nanosized atomic-force-microscopy-type probe and the optical field in a microcavity (MC) at or near resonance. Using a 2-D cross-sectional model of an experimentally studied photonic crystal MC, we have simulated the T-SNOM method by scanning a probe over the surface while monitoring the transmitted and reflected power. The simulations were performed for two probe materials: silicon and silicon nitride. From the probe-induced change in the transmission and reflection spectra, a wavelength shift was extracted. A shift almost proportional to the local field intensity was found if the resonator was excited just below a resonance wavelength. However, at the spots of highest interaction, we observed that besides the desired resonance wavelength shift, there was an increase in scattering. Furthermore, by moving the probe at such a spot in the vertical direction to a height of approximately 0.5, a 5% increase in transmission can be established because the antiresonant condition is satisfied. Finally, a 2-D top view simulation is presented of the experimentally studied T-SNOM method, which shows a remarkably good correspondence in intensity profile, except for the exact location of the high-interaction spots.
Plagiarism and Collusion Detection using the Smith-Waterman Algorithm

We investigate the use of variants of the Smith-Waterman algorithm to locate similarities in texts and in program source code, with a view to their application in the detection of plagiarism and collusion. The Smith-Waterman algorithm is a classical tool in the identification and quantification of local similarities in biological sequences, but we demonstrate that somewhat different issues arise in this different context, and that these factors can be exploited to yield significant speed-up in practice. We include empirical evidence to indicate the practicality of the approach and to illustrate the efficiency gains.
Comparison Among Multilayer Soft X-Ray Mirrors Fabricated By Electron Beam, Dc-, Rf-Magnetron Sputtering And Ion Beam Sputtering Deposition

Multilayer Mo/Si mirrors have been fabricated by various physical vapor deposition methods. The best mirror fabricated by RF-magnetron sputtering showed a reflectivity of 57.8% at an incident angle of 25° and at a wavelength of 12.66 nm with synchrotron radiation reflectometer. The characteristics of fabricated multilayer mirrors have been measured using transmission electron microscope for surface and cross-sectional micrographs, electron diffraction for crystalline nature, small-angle x-ray diffractometer and synchrotron radiation reflectometer for reflectivity. Particularly, the dependencies of deposition parameters of Ar pressure and input power in RF-magnetron sputtering and substrate temperature in electron beam deposition in ultra high vacuum, have been investigated. The crystalization of Mo layers is clearly admitted for the mirrors by DC-and RF-magnetron sputtering. Surface roughness is minimum for the mirrors by RF-magnetron sputtering and ion beam sputtering. A possible reason of low reflectivity for the mirrors by ion beam sputtering is discussed from the resluts of additional analysis.
A review of adaptive feature extraction and classification methods for EEG-based brain-computer interfaces

A brain-computer interface (BCI) is a system that allows its users to control external devices which are independent of peripheral nerves and muscles with brain activities. Electroencephalogram (EEG) signals are electrical signals collected from the scalp. They are frequently used in brain-computer interaction. However, EEG signals which change over time are highly non-stationary. One major challenge in current BCI research is how to extract features of time-varying EEG signals and classify the signals as accurately as possible. An effective BCI should be robust against and adaptive to the dynamic variations of brain activities. Adaptive learning in a BCI system, a rapidly developing application of machine learning, would be an effective approach to conquer the challenge. This paper reviews representative adaptive feature extraction and classification methods for EEG-based BCIs and further discusses some important open problems which can hopefully be useful to promote the research of the BCIs.
Risk Factors for Early Dislocation after Total Hip Arthroplasty: A Matched Case-Control Study

Purpose. To evaluate risk factors for early dislocation after primary total hip arthroplasty (THA). Methods. Records of 175 cases with dislocation during hospitalisation after THA and 651 controls without dislocation were reviewed. Cases and controls were matched for age, gender, body mass index classification, primary diagnosis, cup design, hospital, and year of intervention. Version and inclination of the acetabular component and version of the femoral component were assessed intra- and post-operatively. Various risk factors were analysed, including surgical approach, cup positioning, combined cup and stem positioning, and femoral head size. Results. The posterior approach was 6 fold more prone to dislocation (odds ratio [OR]=6.3, p<0.018) than the anterolateral or straight lateral approach. With regard to combined cup and stem positioning, the acceptable position was at significantly higher risk of dislocation than the ideal position (OR=2.59, p=0.033). Larger femoral head sizes were associated with significantly lower risk of dislocation (OR=0.84, p=0.02). Conclusion. Surgical approach, combined cup and stem positioning, and femoral head size were significant risk factors for dislocation during hospitalisation.
CHARACTERIZATION OF PALM KERNEL SHELL FILLED POLYLACTIC ACID COMPOSITES

In this study, the mechanical properties, morphological studies and thermal properties of the PLA/PKS composites were investigated. The palm kernel shell (PKS) filled polylactic acid (PLA) composites were prepared at different PKS loading by using melt mixing compounding at 180 oC. The 3-aminopropyltriethoxysilane (3-APE) was selected as coupling agent. The incorporation of PKS into PLA had decreased the tensile strength and elongation at break of the PLA/PKS composites. However, the composites’ modulus of elasticity was increased with increase of PKS loading. The PLA/PKS composites treated with 3-APE had higher tensile strength and elongation at break but lower modulus of elasticity. This improvement was attributed to the enhanced PKS-PLA interaction. The better interaction of PKS and PLA was proven through scanning electron microscopy and Fourier transform infrared analysis. The thermal stability of PLA/PKS composites was enhanced with 3-APE treatment.
Stabilization of GroEL minichaperones by core and surface mutations.

We report the crystal structures of two hexa-substituted mutants of a GroEL minichaperone that are more stable than wild-type by 7.0 and 6.1 kcal mol(-1). Their structures imply that the increased stability results from multiple factors including improved hydrophobic packing, optimised hydrogen bonding and favourable structural rearrangements. It is commonly believed that protein core residues are immutable and generally optimized for energy, while on the contrary, surface residues are variable and hence unimportant for stability. But, it is now becoming clear that mutations of both core and surface residues can increase protein stability, and that protein cores are more flexible and thus more tolerant to mutation than expected. Sequence comparison of homologous proteins has provided a way to pinpoint the residues that contribute constructively to stability and to guide the engineering of protein stability. Stabilizing mutations identified by this approach are most frequently located at protein surfaces but with a few found in protein cores. In the latter case, local flexibility in the hydrophobic core is the key factor that allows the energetically favourable burial of larger hydrophobic side-chains without undue energetic penalties from steric clashes.
Optimization for object detector using deep residual network on embedded board

Although many studies on deep neural networks for Advanced Driver Assistance Systems(ADAS) have been emerging, using deeper convolutional neural networks (CNNs) implemented on embedded boards or mobile platforms for the road object detection task is challenging. To deploy a deep CNN pipeline, constraints such as computing power, processing time, battery, and memory capacity need to be overcome. To overcome these constraints, this study proposes a smaller residual CNN architecture with 6× fewer parameters and 3× smaller memory that is adopted by the object detector, a single-shot multibox detector. The proposed method was evaluated using the KITTI dataset on the NVIDIA TX1 embedded board and achieves 10.63 frames per second, which is three times faster compared to the well-known model, the VGGNet.
Effect of Organic Modification of Muscovite on the Polypropylene Layered Silicate Nanocomposite

Polypropylene- layered silicate nanocomposite based on muscovite was prepared via melt compounding. Muscovite was organomodified with cetyltrimethylammoniumbromide (CTAB) by using different filler loading. The effects of muscovite content on mechanical and morphology properties were evaluated. Analysis of test data showed that the mechanical properties increased with an increase in filler loading up to a threshold of 3 wt%; thereafter the material properties were degraded. The enhancement of properties attributed to the formation of intercalated and exfoliation nanocomposite structure at these loadings of clay. At higher filler loading, degradation in mechanical properties maybe attributed to the formation of agglomerated clay tactoids.
Oxidative dechroming of leather shavings under ultrasound

The oxidative dechroming of leather shavings using hydrogen peroxide under ultrasound was studied. It was shown that the chrome removal rate from the shavings was influenced by reaction time, temperature, medium and intensity of ultrasound. When 20kHz and 40kHz ultrasound are employed, the intensity of ultrasound should be regulated to 7-8W/cm 2 . The proper circumstance for ultrasonic oxidation dechroming is 20°C and pH 9.0-10 adjusted by CaO. In these conditions, dechromed with 10% hydrogen peroxide (conc.30%) under ultrasound 8 times, a chrome removal rate of 99.46% can be achieved, which is markedly higher than 89.60%, the chrome removal rate using a conventional method of oxidation dechroming.
Evaluation of tobacco use on Chinese population through ATTOC model: a cross-sectional survey on hospitalized psychiatric patients.

OBJECTIVES To evaluate the feasibility of Addressing Tobaccos through Organizational Change (ATTOC) intervention to Chinese psychiatric patients, and to better address tobacco use through the ATTOC intervention model in the context of China. METHODS The study was conducted in Mental Health Center of West China Hospital in 2010. A total of 100 hospitalized psychiatric patients were recruited to carry out ATTOC intervention. Subjects suffers from mental illness were diagnosed by professional psychiatrists according to the International Statistical Classification of Diseases (ICD-10) criteria. RESULTS The prevalence of tobacco use in hospitalized psychiatric patients were closely correlated with the type of mental illness, family smoking history, sex, age, marital status, education status, etc. However, most psychiatric patients knew little about these, and tended to ignore the importance of smoking cessation. CONCLUSIONS The ATTOC intervention program of the U.S. may be suitable for hospitalized Chinese psychiatric patients, and it could be applied for the tobacco smoking treatment in China. However, the health effects of tobacco use still did not draw amount attentions from both the clinicians and general public. It is urgently needed to raise people's awareness and carry out ATTOC intervention to control tobacco use, and ultimately terminate tobacco use.