Miracle-dz/UniFAR-FTUs huggingface dataset:
Etiology and occurrence of gingival recession - An epidemiological study

Objectives: Gingival recession is the term used to characterize the apical shift of the marginal gingiva from its normal position on the crown of the tooth. It is frequently observed in adult subjects. The occurrence and severity of the gingival recession present considerable differences between populations. To prevent gingival recession from occurring, it is essential to detect the underlying etiology. The aim of the present study was to determine the occurrence of gingival recession and to identify the most common factor associated with the cause of gingival recession. Methods: A total of 710 subjects aged between 15 years to 60 years were selected. Data were collected by an interview with the help of a proforma and then the dental examination was carried out. The presence of gingival recession was recorded using Miller's classification of gingival recession. The Silness and Loe Plaque Index, Loe and Silness gingival index, community periodontal index were recorded. The data thus obtained were subjected to statistical analysis using Chi-square test and Student's unpaired t-test. Results: Of 710 subjects examined, 291 (40.98%) subjects exhibited gingival recession. The frequency of gingival recession was found to increase with age. High frequency of gingival recession was seen in males (60.5%) compared to females (39.5%). Gingival recession was commonly seen in mandibular incisors (43.0%). Miller's class I gingival recession was more commonly seen. The most common cause for gingival recession was dental plaque accumulation (44.1%) followed by faulty toothbrushing (42.7%). Conclusion: Approximately half of the subjects examined exhibited gingival recession. The etiology of gingival recession is multifactorial, and its appearance is always the result of more than one factor acting together.
Cigarette smoke-induced lung inflammation in COPD mediated via LTB4/BLT1/SOCS1 pathway

Background Evidence suggests that suppressor of cytokine signaling 1 (SOCS1) is crucial for the negative regulation of inflammation. We investigated the relationship between smoking, SOCS1, and leukotriene B4 (LTB4) in vitro and in clinical samples of COPD; besides which we detected the impact of LTB4 receptor 1 (BLT1) antagonist on inflammation. Methods SOCS1 expression in bronchial mucosa was determined by immunohistochemistry and real-time polymerase chain reaction. We also detect SOCS1 and BLT1 expression in alveolar macrophages from bronchoalveolar lavage fluid (BALF) by real time-PCR, in addition to measuring the level of cytokines in BALF using enzyme-linked immunosorbent assay. In vitro, we investigated the expression of SOCS1 in cigarette smoke extract-induced mouse macrophage cell line RAW264.7 by real-time polymerase chain reaction and Western blot, and detected the level of cytokines in the supernatant by enzyme-linked immunosorbent assay. Then, we investigated the effects of BLT1 antagonist U-75302 on SOCS1 expression in these cells. Results We obtained endobronchial biopsies (15 COPD patients and 12 non-COPD control subjects) and BALF (20 COPD patients and 20 non-COPD control subjects), and our results showed that SOCS1 expression significantly decreased in lung tissues from COPD patients. Inflammatory cytokines in BALF were higher in COPD and these inflammatory cytokines negatively correlate with SOCS1 levels. Further, the BLT1 antagonist restored SOCS1 expression and in turn inhibited inflammatory cytokine secretion in vitro. Conclusion Long-term cigarette smoke exposure induced SOCS1 degradation and LTB4 accumulation, which was associated with emphysema and inflammation. A BLT1 antagonist might be a potential therapeutic candidate for the treatment of COPD.
Validation of Empirical Measures of Welfare Change: Comment and Extension

A complex of polyphenylene ether resin and methylene chloride obtained by polymerizing a phenol in methylene chloride and then cooling the mixture to cause the complex to precipitate, is mixed with a vinyl aromatic compound, e.g., styrene monomer, heated to decompose the complex and remove methylene chloride from the blend, and thereafter the vinyl aromatic compound is polymerized. The products are useful as molding resins and the like.
Activity‐dependent regulation of ‘on’ and ‘off’ responses in cat visual cortical receptive fields

1 A supervised learning procedure was applied to individual cat area 17 neurons to test the possible role of neuronal co‐activity in controlling the plasticity of the spatial ‘on‐off’ organization of visual cortical receptive fields (RFs). 2 Differential pairing between visual input evoked in a fixed position of the RF and preset levels of postsynaptic firing (imposed iontophoretically) were used alternately to boost the ‘on’ (or ‘off’) response to a ‘high’ level of firing (S+ pairing), and to reduce the opponent response (respectively ‘off’ or ‘on’) in the same position to a ‘low’ level (S− pairing). This associative procedure was repeated 50‐100 times at a low temporal frequency (0.1‐0.15 s−1). 3 Long‐lasting modifications of the ratio of ‘on‐off’ responses, measured in the paired position or integrated across the whole RF, were found in 44 % of the conditioned neurons (17/39), and in most cases this favoured the S+ paired characteristic. The amplitude change was on average half of that imposed during pairing. Comparable proportions of modified cells were obtained in ‘simple’ (13/27) and ‘complex’ (4/12) RFs, both in adult cats (4/11) and in kittens within the critical period (13/28). 4 The spatial selectivity of the pairing effects was studied by pseudorandomly stimulating both paired and spatially distinct unpaired positions within the RF. Most modifications were observed in the paired position (for 88 % of successful pairings). 5 In some cells (n= 13), a fixed delay pairing procedure was applied, in which the temporal phase of the onset of the current pulse was shifted by a few hundred milliseconds from the presentation or offset of the visual stimulus. Consecutive effects were observed in 4/13 cells, which retained the temporal pattern of activity imposed during pairing for 5‐40 min. They were expressed in the paired region only. 6 The demonstration of long‐lasting adaptive changes in the ratio of ‘on’ and ‘off’ responses, expressed in localized subregions of the RF, leads us to suggest that simple and complex RF organizations might be two stable functional states derived from a common connectivity scheme.
Style-Oriented Personalized Landmark Recommendation

Personalized travel recommendation has attracted lots of research attention in both academic and industry communities. Although a great progress has been achieved so far, existing travel recommender systems have not well-exploited users’ style-oriented preference on landmarks and local preference on the targeted city. Typically, users have their own preferences on the styles of landmarks (e.g., natural scenes or historic sites). When visiting a city, their preferences will be affected by the characteristics of this city (e.g., historic or scenic) or the “must-go” landmarks, as well as local contexts such as distance and time constraints. In this paper, we propose a novel style-oriented recommender system, which considers all the above factors to facilitate personalized landmark recommendation. Specifically, we first propose a unified classifier to detect landmark styles based on domain adaptation by leveraging web-photos in the source domain and landmark-image in the target domain. The detected landmark styles are then utilized to learn users’ style-oriented preferences based on users’ travel records in the past. Next, given a targeted city, the influence of users’ landmark style preferences and the characteristics of the must-go landmarks of this city are simultaneously considered by a proposed style-oriented recommender system to make optimal recommendations. In addition, we further study the effects of local contexts, such as landmark popularity or location, on the performance of landmark recommendation. Extensive experiments on the real-world travel data of six cities demonstrate the effectiveness of the proposed style-oriented landmark recommendation strategy.
Two-port network model of fixed-speed wind turbine generator for distribution system load flow analysis

Load flow analysis has always been used in determining the steady-state operation of an electric power or distribution system. For conventional power system without wind turbine generator, the method for load flow analysis has been well established. However, for modern system embedded with wind turbine generator, the investigation of analysis method is still an active research area. This paper proposed a new method to integrate fixed-speed wind turbine generator into distribution system load flow analysis. The proposed method is derived based on two-port network theory where the parameters of induction generator of the wind turbine generator are embedded in general constants of the two-port network. The proposed method has been tested and verified using a representative electric distribution system.
Stem Cells , Tissue Engineering , and Hematopoietic Elements-Catenin Dosage Is a Critical Determinant of Tracheal Basal Cell Fate Determination

The purpose of this study was to determine whether -catenin regulates basal cell fate determination in the mouse trachea. Analysis of TOPGal transgene reporter activity and Wnt/ -catenin pathway gene expression suggested a role for -catenin in basal cell proliferation and differentiation after naphthalenemediated Clara-like and ciliated cell depletion. However, these basal cell activities occurred simultaneously, limiting precise determination of the role(s) played by -catenin. This issue was overcome by analysis of -catenin signaling in tracheal air-liquid interface cultures. The cultures could be divided into two phases: basal cell proliferation and basal cell differentiation. A role for -catenin in basal cell proliferation was indicated by activation of the TOPGal transgene on proliferation days 3 to 5 and by transient expression of Myc (alias c-myc). Another peak of TOPGal transgene activity was detected on differentiation days 2 to 10 and was associated with the expression of Axin 2. These results suggest a role for -catenin in basal to ciliated and basal to Clara-like cell differentiation. Genetic stabilization of -catenin in basal cells shortened the period of basal cell proliferation but had a minor effect on this process. Persistent -catenin signaling regulated basal cell fate by driving the generation of ciliated cells and preventing the production of Clara-like cells. (Am J Pathol 2011, 179:367–379; DOI: 10.1016/j.ajpath.2011.03.016)
The United Nations Parallel Corpus v1.0

This paper describes the creation process and statistics of the official United Nations Parallel Corpus, the first parallel corpus composed from United Nations documents published by the original data creator. The parallel corpus presented consists of manually translated UN documents from the last 25 years (1990 to 2014) for the six official UN languages, Arabic, Chinese, English, French, Russian, and Spanish. The corpus is freely available for download under a liberal license. Apart from the pairwise aligned documents, a fully aligned subcorpus for the six official UN languages is distributed. We provide baseline BLEU scores of our Moses-based SMT systems trained with the full data of language pairs involving English and for all possible translation directions of the six-way subcorpus.
Isomorphisms of Hilbert $C^*$-modules and *-isomorphisms of related operator $C^*$-algebras.

Let $\cal M$ be a Banach C*-module over a C*-algebra $A$ carrying two $A$-valued inner products $ _1$, $ _2$ which induce equivalent to the given one norms on $\cal M$. Then the appropriate unital C*-algebras of adjointable bounded $A$-linear operators on the Hilbert $A$-modules $\{ {\cal M}, _1 \}$ and $\{ {\cal M}, _2 \}$ are shown to be $*$-isomorphic if and only if there exists a bounded $A$-linear isomorphism $S$ of these two Hilbert $A$-modules satisfying the identity $ _2 \equiv _1$. This result extends other equivalent descriptions due to L. ~G. ~Brown, H. ~Lin and E. ~C. ~Lance. An example of two non-isomorphic Hilbert C*-modules with $*$-isomorphic C*-algebras of ''compact''/adjointable bounded module operators is indicated.
Inactivation of p53 and Amplification of Cyclin D1 Correlate With Clinical Outcome in Head and Neck Cancer

The authors have investigated whether genetic abnormalities in two genes, loss of heterozygosity (LOH) of p53 and amplification of the cyclin D1 gene, correlate with clinical outcome in 56 matched pairs of blood and tumor from patients with squamous cell carcinoma of the head and neck (SCCHN). Frequency of p53 LOH was 47.4%, of cyclin D1 amplification 33.9%, and of both abnormalities together 23.7%. p53 LOH was associated with T4 (P = 0.003) and stage IV (P = 0.015) tumors. Cyclin D1 amplification was associated with recurrences and/or metachronous tumors (P = 0.007). The total number of p53 and cyclin D1 abnormalities (scored as zero, one, and two) show a pattern that seems to be additive; the increase in the number of these abnormalities is associated with a proportional increase in the frequency of T4, stage IV, presence of recurrences and/or metachronous tumors, and possibly a proportional decrease in the disease‐free interval in the sample. The association of the markers with recurrences and/or metachronous tumors persists if the tumor stage effect is mathematically removed. The combined analysis of the p53 and cyclin D1 abnormalities seems to be more informative than either of them individually and may have predictive value in SCCHN.
Pathogenesis of bloodstream infection in children with blood cancer

The aim of the present study was to characterize the distribution and antibiotic resistance of pathogens isolated from patients with bloodstream infections (BSIs) in the Hematology and Oncology department of the Affiliated Children’s Hospital of Zhejiang University Medical School (Hangzhou, China), between January and December 2010 and to provide early and appropriate support for the clinical administration of antibiotics. Out of 1,500 inpatients, 161 children who were diagnosed with BSI based on the national diagnostic criteria were retrospectively analyzed. Neutropenia was defined as an absolute neutrophil count (ANC) in the peripheral blood of less than 0.5×109 cells/l. A microbiologically documented infection (MDI) was defined as when the causative pathogen was isolated from the blood. Drug susceptibility tests were performed using a VITEK-60 AutoMicrobic System and the Kirby-Bauer disk diffusion method. The data were analyzed using STATA software (version 9.0) and a two-sided P-value of ≤0.05 was considered to indicate a statistically significant difference. A total of 79 strains were isolated from the blood specimens. The incidence of BSI was 10.73% (161/1,500). Gram-positive cocci, Gram-negative bacilli and fungi accounted for 55.70, 43.04 and 1.27% of the BSIs, respectively. Staphylococcus epidermidis (20.25%), Escherichia coli (15.19%) and Klebsiella pneumoniae (15.19%) were frequently identified isolates. The staphylococci were susceptible to vancomycin and linezolid, while Escherichia coli and Klebsiella pneumoniae were sensitive to cefoperazone/sulbactam, imipenem and meropenem. In conclusion, Gram-positive bacteria are slightly more prevalent than Gram-negative bacteria in BSI and the selection of antibiotics according to the susceptibility test results is superior to empirical treatment. It is essential to administer antimicrobial agents early and appropriately to treat child blood cancer patients with BSI.
Role for immune monitoring to tailor induction prophylaxis in pediatric heart recipients

rATG is used for HTx induction but is costly and associated with infection and PTLD. Hypothesis: Tailoring rATG induction with CD3 monitoring results in less infection, reduced costs, and similar rejection. Retrospective review of HTx recipients receiving rATG induction. Control cases received “usual” rATG dosing (1.5 mg/kg/day typically × 5 days). Starting in October 2009, absolute CD3 monitoring (target <25 cells/mm3) guided rATG dosing (study cases). Outcomes included first‐year incidence of infection/rejection, direct costs of therapy, and incidence of PTLD/death. Study cases (n = 32) received fewer doses of rATG (median 4 vs. 5, p < 0.001) and less total rATG (median 3.2 vs. 7.4 mg/kg, p < 0.001) compared with controls (n = 17). There was no difference in incidence of infection, rejection, or patient survival during the first year post‐HTx. There was one early death in both groups and one late case of PTLD in the control group. Drug savings were significant (median drug cost per patient $2718 vs. $4756, p < 0.001). CD3‐tailored rATG induction in HTx recipients is associated with reduced drug costs and similar rates of rejection/infection. Longer follow‐up will determine whether extended benefits are associated with this induction monitoring strategy.
Genetic variation of temperature-regulated curd induction in cauliflower: elucidation of floral transition by genome-wide association mapping and gene expression analysis

Cauliflower (Brassica oleracea var. botrytis) is a vernalization-responsive crop. High ambient temperatures delay harvest time. The elucidation of the genetic regulation of floral transition is highly interesting for a precise harvest scheduling and to ensure stable market supply. This study aims at genetic dissection of temperature-dependent curd induction in cauliflower by genome-wide association studies and gene expression analysis. To assess temperature-dependent curd induction, two greenhouse trials under distinct temperature regimes were conducted on a diversity panel consisting of 111 cauliflower commercial parent lines, genotyped with 14,385 SNPs. Broad phenotypic variation and high heritability (0.93) were observed for temperature-related curd induction within the cauliflower population. GWA mapping identified a total of 18 QTL localized on chromosomes O1, O2, O3, O4, O6, O8, and O9 for curding time under two distinct temperature regimes. Among those, several QTL are localized within regions of promising candidate flowering genes. Inferring population structure and genetic relatedness among the diversity set assigned three main genetic clusters. Linkage disequilibrium (LD) patterns estimated global LD extent of r2 = 0.06 and a maximum physical distance of 400 kb for genetic linkage. Transcriptional profiling of flowering genes FLOWERING LOCUS C (BoFLC) and VERNALIZATION 2 (BoVRN2) was performed, showing increased expression levels of BoVRN2 in genotypes with faster curding. However, functional relevance of BoVRN2 and BoFLC2 could not consistently be supported, which probably suggests to act facultative and/or might evidence for BoVRN2/BoFLC-independent mechanisms in temperature-regulated floral transition in cauliflower. Genetic insights in temperature-regulated curd induction can underpin genetically informed phenology models and benefit molecular breeding strategies toward the development of thermo-tolerant cultivars.
Correlates of lens thickness: the Beaver Dam Eye Study.

PURPOSE To evaluate the relationships of lens thickness to age, to the presence of a nuclear, cortical, or posterior subcapsular cataract, and to other personal characteristics in participants in the Beaver Dam Eye Study. METHODS Slit lamp photographs taken during a population-based prevalence study were measured for lens thickness. In addition, slit lamp photographs were graded for nuclear cataracts, and retroillumination photographs were graded for cortical and posterior subcapsular cataracts. A questionnaire was administered, and height, weight, and blood pressure were measured by protocol. RESULTS Lens thickness increased systematically with age in men and women. In multivariate analysis, age, sex (male), cortical cataract, diabetes, nuclear cataract, and former cigarette smoking were related significantly to lens thickness. CONCLUSIONS Age was the most significant personal characteristic associated with lens thickness among those subjects considered. In addition, other characteristics, including specific cataract types and risk factors for cataracts, also were associated with thickness. Whether lens thickness among people of the same age is associated prospectively with these characteristics requires a longitudinal follow-up.
TD-DFT Performance for the Visible Absorption Spectra of Organic Dyes:  Conventional versus Long-Range Hybrids.

The π → π* transitions of more than 100 organic dyes from the major classes of chromophores (quinones, diazo, .) have been investigated using a Time-Dependent Density Functional Theory (TD-DFT) procedure relying on large atomic basis sets and the systematic modeling of solvent effects. These calculations have been performed with pure (PBE) as well as conventional (PBE0) and long-range (LR) corrected hybrid functionals (LC-PBE, LC-ωPBE, and CAM-B3LYP). The computed wavelengths are systematically guided by the percentage of exact exchange included at intermediate interelectronic distance, i.e., the λmax value always follows the PBE > PBE0 > CAM-B3LYP > LC-PBE > LC-ωPBE > HF sequence. The functional giving the best estimates of the experimental transition energies may vary, but PBE0 and CAM-B3LYP tend to outperform all other approaches. The latter functional is shown to be especially adequate to treat molecules with delocalized excited states. The mean absolute error provided by PBE0 is 22 nm (0.14 eV) with no deviation exceeding 100 nm (0.50 eV): PBE0 is able to deliver reasonable estimates of the color of most organic dyes of practical or industrial interest. By using a calibration curve, we found that the LR functionals systematically allow an even more consistent description of the low-lying excited-state energies than the conventional hybrids. Indeed, linearly corrected LR approaches yield an average error of 10 nm for each dye family. Therefore, when such statistical treatments can be designed for given sets of dyes, a simple and rapid theoretical procedure allows both a chemically sound and a numerically accurate description of the absorption wavelengths.
Distributed control for optimal reactive power compensation in smart microgrids

We consider the problem of optimal reactive power compensation for the minimization of power distribution losses in a smart microgrid. We first propose an approximate model for the power distribution network, which allows us to cast the problem into the class of convex quadratic, linearly constrained, optimization problems. We also show how agents have a partial knowledge of the problem parameters and state via some local measurements. Then, we design a randomized, gossip-like optimization algorithm, providing conditions for convergence together with an analytical characterization of the convergence speed. The analysis shows that the best performance is achieved when we command cooperation among agents that are neighbors in the smart microgrid topology.