Miracle-dz/UniFAR-FTUs huggingface dataset:
Interaction of Genetic and Environmental Factors in a Drosophila Parkinsonism Model

Catastrophic loss of dopaminergic neurons is a hallmark of Parkinson's disease. Despite the recent identification of genes associated with familial parkinsonism, the etiology of most Parkinson's disease cases is not understood. Environmental toxins, such as the herbicide paraquat, appear to be risk factors, and it has been proposed that susceptibility is influenced by genetic background. The genetic model organism Drosophila is an advantageous system for the identification of genetic susceptibility factors. Genes that affect dopamine homeostasis are candidate susceptibility factors, because dopamine itself has been implicated in neuron damage. We find that paraquat can replicate a broad spectrum of parkinsonian behavioral symptoms in Drosophila that are associated with loss of specific subsets of dopaminergic neurons. In parallel with epidemiological studies that show an increased incidence of Parkinson's disease in males, male Drosophila exhibit paraquat symptoms earlier than females. We then tested the hypothesis that variation in dopamine-regulating genes, including those that regulate tetrahydrobiopterin, a requisite cofactor in dopamine synthesis, can alter susceptibility to paraquat-induced oxidative damage. Drosophila mutant strains that have increased or decreased dopamine and tetrahydrobiopterin production exhibit variation in susceptibility to paraquat. Surprisingly, protection against the neurotoxicity of paraquat is conferred by mutations that elevate dopamine pathway function, whereas mutations that diminish dopamine pools increase susceptibility. We also find that loss-of-function mutations in a negative regulator of dopamine production, Catecholamines-up, delay the onset of neurological symptoms, dopaminergic neuron death, and morbidity during paraquat exposure but confer sensitivity to hydrogen peroxide.
An Entropy-Perspective Study on the Sustainable Development Potential of Tourism Destination Ecosystem in Dunhuang, China

This paper analyzed the characteristic of the tourism destination ecosystem from perspective of entropy in Dunhuang City. Given these circumstances, an evaluation index system that considers the potential of sustainable development was formed based on dissipative structure and entropy change for the tourism destination ecosystem. The sustainable development potential evaluation model for tourism destination ecosystem was built up based on information entropy. Then, we analyzed each indicator impact for the sustainable development potential and proposed some measures for the tourism destination ecosystem. The conclusions include: (a) the requirements of Dunhuang tourism destination ecosystem on the natural ecosystem continuously grew between 2000 and 2012; (b) The sustainable development potential of the Dunhuang tourism destination ecosystem was on an oscillation upward trend during the study period, which is dependent on government attention, and pollution problems were improved.
Comparative Study of Pre-Peritoneal Versus Onlay Mesh Repair of Ventral Hernias

Aim: To compare the efficacy of Preperitoneal and Onlay mesh repair of Ventral Hernia. Methodology: It was a prospective, observational and comparative study. 50 patients presenting with ventral hernia admitted to Kamineni institute of medical sciences, Narketpally, were preoperatively assessed clinically and by ultrasonography to confirm the diagnosis. 26 patients underwent Onlay and 24 patients underwent Preperitoneal mesh repair after obtaining Informed consent and satisfying the inclusion & exclusion criteria. Results: The age in the study ranged from 22 years to 65 years’ age group. More than 50% patients were between 31-60 age groups. In our study out of 28 cases with incisional hernia, 9 cases (32.14%) had under gone Hysterectomy(TAH), 2 Tubectomy (7.14%),6 LSCS (21.44%), 2 open appendectomies (7.14%), 7 laparotomy(25%),1 oophorectomy (3.57%), 1 psoas abscess (3.57%). The smallest defect measured 1 x 0.5 cm and the largest defect measured 7 x 4 cm in this study. 24 Patients underwent Pre-peritoneal mesh repair and 26 patients underwent onlay mesh repair. Mean duration of surgery in Onlay Mesh repair (60 – 100mins) was 77.08 mins compared to that in Pre-Peritoneal Mesh repair was 95.63mins (70 – 125 mins). Recurrence was observed only in one patient with Onlay mesh repair . Conclusion: The study concluded that Preperitoneal mesh repair is a good alternative to Onlay mesh repair that may be applicable to all forms of ventral hernias.
Control of MEMS Vibration Modes With Pulsed Digital Oscillators—Part II: Simulation and Experimental Results

This paper extends our previous work on the selective excitation of mechanical vibration modes in MEMS devices using pulsed digital oscillators (PDOs). It begins by presenting extensive simulation results using the set of iterative maps that model the system and showing that it is possible to activate two or three spatial modes (resonances) of the mechanical structure with a PDO. The second part of this paper presents experimental results corroborating the theory and simulation results. It is shown that it is possible to separately excite vibration modes of the device by setting a few parameters of the PDO structure such as the sampling frequency and the sign of the feedback loop.
Melanocortins and the Treatment of Nervous System Disease: Potential Relevance to the Skin?

ABSTRACT: For several decades melanocortins have been implicated in the modulation of brain function. More recently, this idea has been supported by the identification and cloning of melanocortin (MC) receptors in the nervous system. MCs stimulate axonal growth in fetal neural tissue or in neural cell lines in culture. This feature was utilized in screening their neurotrophic or neuroprotection potential in animal studies of nervous system disease (peripheral nerve and spinal cord trauma, toxic and metabolic neuropathies, EAN, EAE, etc.). Some of these effects may be mediated by MC4 receptor activation, although as yet unknown receptors may also be involved (for instance, protection by Org 2766). To what extent MC‐nervous system effects are related to known effects of MCs in skin‐ and neuro‐immune systems, remains to be discovered. Nevertheless, it is of interest to note that activation of brain MC4 receptors profoundly affects care behavior for the body surface (skin and fur). The excessive grooming response in rodents exhibits a remarkable functional correlation with MSH activity in a brain‐skin axis.
Prevalence of extravertebral cement leakage after vertebroplasty: procedural documentation versus CT detection

Background Reported incidence of extravertebral cement leakage after vertebroplasty varies widely across studies. Purpose To retrospectively compare the relative detection rates of extravertebral leakage noted under intra-procedural fluoroscopic surveillance, postprocedure plain radiographs, and postprocedure computed tomography (CT) in a cohort of patients undergoing vertebroplasty. Material and Methods With IRB approval, we retrospectively identified 181 patients with 277 levels treated with percutaneous vertebroplasty among a total of 1255 patients undergoing vertebroplasty between 1999 and 2010 who had subsequently undergone a CT examination that included the treated level(s). Categories of leakage were paravertebral, end plate, epidural, and prevertebral venous leakage. CT-detected leak rates were then compared to those noted on the vertebroplasty procedure reports and the archived fluoroscopic images for this same cohort using Pearson's χ2 test. Results One hundred and forty-nine (82%, 95% CI 76–87%) of 181 patients demonstrated evidence of some type of leakage on CT at one or more treated levels. Sixty-two (34%, 95% CI 28–42%) and seventy-seven (50%, 95% CI 43–57%) of 149 CT-detected leaks were reported in the procedural dictation or detected on plain radiography (P = 0.01 and 0.006, respectively). The most common type of leakage noted on CT was end plate (n = 81, 45%, 95% CI 38–52%), followed by paravertebral (n = 64, 35%, 95% CI 29–43%), epidural (n = 36, 20%, 95% CI 15–26%), and prevertebral venous (n = 32, 18%, 95% CI 13–24%). Conclusion Cement leakage after vertebroplasty is common and is often not reported by operators in procedural dictations. CT detects substantially more leaks than plain radiography.
HIV-1 Cell to Cell Transfer across an Env-induced, Actin-dependent Synapse

Direct cell–cell transfer is an efficient mechanism of viral dissemination within an infected host, and human immunodeficiency virus 1 (HIV-1) can exploit this mode of spread. Receptor recognition by HIV-1 occurs via interactions between the viral surface envelope glycoprotein (Env), gp120, and CD4 and a chemokine receptor, CCR5 or CXCR4. Here, we demonstrate that the binding of CXCR4-using HIV-1–infected effector T cells to primary CD4+/CXCR4+ target T cells results in rapid recruitment to the interface of CD4, CXCR4, talin, and lymphocyte function–associated antigen 1 on the target cell, and of Env and Gag on the effector cell. Recruitment of these membrane molecules into polarized clusters was dependent on Env engagement of CD4 and CXCR4 and required remodelling of the actin cytoskeleton. Transfer of Gag from effector to target cell was observed by 1 h after conjugate formation, was independent of cell–cell fusion, and was probably mediated by directed virion fusion with the target cell. We propose that receptor engagement by Env directs the rapid, actin-dependent recruitment of HIV receptors and adhesion molecules to the interface, resulting in a stable adhesive junction across which HIV infects the target cell.
Quenching of the accretion disk strong aperiodic variability at the magnetospheric boundary

We study power density spectra (PDS) of X-ray flux variability in binary systems where the accretion flow is truncated by the magnetosphere. PDS of accreting X-ray pulsars where the neutron star is close to the corotation with the accretion disk at the magnetospheric boundary, have a distinct break/cutoff at the neutron star spin frequency. This break can naturally be explained in the "perturbation propagation" model, which assumes that at any given radius in the accretion disk stochastic perturbations are introduced to the flow with frequencies characteristic for this radius. These perturbations are then advected to the region of main energy release leading to a self-similar variability of X-ray flux P~f^{-1. -1.5}. The break in the PDS is then a natural manifestation of the transition from the disk to magnetospheric flow at the frequency characteristic for the accretion disk truncation radius (magnetospheric radius). The proximity of the PDS break frequency to the spin frequency in corotating pulsars strongly suggests that the typical variability time scale in accretion disks is close to the Keplerian one. In transient accreting X-ray pulsars characterized by large variations of the mass accretion rate during outbursts, the PDS break frequency follows the variations of the X-ray flux, reflecting the change of the magnetosphere size with the accretion rate. Above the break frequency the PDS steepens to ~f^{-2} law which holds over a broad frequency range. These results suggest that strong f^{-1. -1.5} aperiodic variability which is ubiquitous in accretion disks is not characteristic for magnetospheric flows.
Applicability of Information Theory to the Quantification of Responses to Anthropogenic Noise by Southeast Alaskan Humpback Whales

Abstract: We assess the effectiveness of applying information theory to the characterization and quantification of the affects of anthropogenic vessel noise on humpback whale ( Megaptera novaeangliae ) vocal behavior in and around Glacier Bay, Alaska. Vessel noise has the potential to interfere with the complex vocal behavior of these humpback whales which could have direct consequences on their feeding behavior and thus ultimately on their health and reproduction. Humpback whale feeding calls recorded during conditions of high vessel-generated noise and lower levels of background noise are compared for differences in acoustic structure, use, and organization using information theoretic measures. We apply information theory in a self-referential manner (i.e., orders of entropy) to quantify the changes in signaling behavior. We then compare this with the reduction in channel capacity due to noise in Glacier Bay itself treating it as a (Gaussian) noisy channel. We find that high vessel noise is associated with an increase in the rate and repetitiveness of sequential use of feeding call types in our averaged sample of humpback
Automating Knowledge Acquisition for Machine Translation

Machine translation of human languages (for example, Japanese, English, Spanish) was one of the earliest goals of computer science research, and it remains an elusive one. Like many AI tasks, trans-lation requires an immense amount of knowledge about language and the world. Recent approaches to machine translation frequently make use of text-based learning algorithms to fully or partially automate the acquisition of knowledge. This article illustrates these approaches.
The Implantable Neurocybernetic Prosthesis System

The neurocybernetic prosthesis system (NCP) is an implantable, multiprogrammable pulse generator that delivers constant current electrical signals to the vagus nerve for the purpose of reducing the frequency and severity of epileptic seizures. The signals are delivered on a predetermined schedule, or may be initiated by the patient with an external magnet. The device is implanted in a subcutaneous pocket in the chest just below the clavicle, similar to pacemaker placement. The stimulation signal is transmitted from the prosthesis to the vagus nerve through a lead connected to an electrode which is a multi‐turn silicone helix, with a platinum band on the inner turn of one helix. The prosthesis can be programmed with any IBM‐ compatible personal computer using NCP software and a programming wand.
Y-Single Nucleotide Polymorphisms Diversity in Chinese Indigenous Horse

In contrast to high genetic diversity of mitochondrial DNA (mtDNA), equine Y chromosome shows extremely low variability, implying limited patrilines in the domesticated horse. In this study, we applied direct sequencing and restriction fragment length polymorphism (RFLP) methods to investigate the polymorphisms of 33 Y chromosome specific loci in 304 Chinese indigenous horses from 13 breeds. Consequently, two Y-single nucleotide polymorphisms (SNPs) (Y-45701/997 and Y-50869) and one Y-indel (Y-45288) were identified. Of those, the Y-50869 (T>A) revealed the highest variation frequency (24.67%), whereas it was only 3.29% and 1.97% in Y-45288 (T/-) and Y-45701/997 (G>T) locus, respectively. These three mutations accounted for 27.96% of the total samples and identified five Y-SNP haplotypes, demonstrating genetic diversity of Y chromosome in Chinese horses. In addition, all the five Y-SNP haplotypes were shared by different breeds. Among 13 horse breeds analyzed, Balikun horse displayed the highest nucleotide diversity (π = 5.6×10−4) and haplotype diversity (h = 0.527), while Ningqiang horse showed the lowest nucleotide diversity (π = 0.00000) and haplotype diversity (h = 0.000). The results also revealed that Chinese horses had a different polymorphic pattern of Y chromosome from European and American horses. In conclusion, Chinese horses revealed genetic diversity of Y chromosome, however more efforts should be made to better understand the domestication and paternal origin of Chinese indigenous horses.
The Effect of Gabapentin on Reducing Pain After Laparoscopic Gastric Bypass Surgery in Patients With Morbid Obesity: A Randomized Clinical Trial

Background: Pain after laparoscopic gastric bypass surgery (LGBP) is a major problem. Gabapentin is an anticonvulsant drug that can be effective in postoperative pain control. Objectives: This study examined the effect of preoperative administration of gabapentin on reducing pain after LGBP in patients with morbid obesity. Patients and Methods: This randomized clinical trial was performed in Hazrat Rasoul Akram Medical Center in Tehran. A total of 60 patients undergoing LGBP were randomly allocated into two groups; one group received 100 mg of oral gabapentin and the other group received placebo. Pain was evaluated at recovery time, and at the first, second, fourth and sixth hour of surgery by visual analog scale. The number and dose of opioid use after surgery and incidence of postoperative complications, such as nausea and vomiting, agitation, and headache, were also recorded. Results: The mean pain score in the group receiving gabapentin was significantly lower than the placebo group (P < 0.001). Indications and dose of opioid consumption between the two groups were not statistically significant. Incidence of nausea/vomiting (P = 0.028) as well as agitation (P = 0.037) was significantly lower in the gabapentin group. Conclusions: Administration of gabapentin before surgery can reduce pain after LGBP. Furthermore, it is not accompanied by significant short-term adverse effects.
Copper Promotes the Trafficking of the Amyloid Precursor Protein*

Accumulation of the amyloid β peptide in the cortical and hippocampal regions of the brain is a major pathological feature of Alzheimer disease. Amyloid β peptide is generated from the sequential protease cleavage of the amyloid precursor protein (APP). We reported previously that copper increases the level of APP at the cell surface. Here we report that copper, but not iron or zinc, promotes APP trafficking in cultured polarized epithelial cells and neuronal cells. In SH-SY5Y neuronal cells and primary cortical neurons, copper promoted a redistribution of APP from a perinuclear localization to a wider distribution, including neurites. Importantly, a change in APP localization was not attributed to an up-regulation of APP protein synthesis. Using live cell imaging and endocytosis assays, we found that copper promotes an increase in cell surface APP by increasing its exocytosis and reducing its endocytosis, respectively. This study identifies a novel mechanism by which copper regulates the localization and presumably the function of APP, which is of major significance for understanding the role of APP in copper homeostasis and the role of copper in Alzheimer disease.
Floating-Point Matrix Multiplication in a Polymorphic Processor

We consider 64-bit floating-point matrix multiplication in the context of polymorphic processor architectures. Our proposal provides a complete and performance efficient solution of the matrix multiplication problem, including hardware design and software interface. We adopt previous ideas1, originally proposed for loosely coupled processors and message passing communications. We employ these ideas into a tightly coupled custom computing unit (CCU) in the Molen polymorphic processor. Furthermore, we introduce a controller, which facilitates the efficient operation of the multiplier processing elements (PEs) in a polymorphic environment. The design is evaluated theoretically and through real hardware experiments. More precisely, we fit 9 processing elements in an XC2VP30-6 device; this configuration suggests theoretical peak performance of 1.80 GFLOPS. In practice, we measured sustained performance of up to 1.79 GFLOPS for the matrix multiplication on real hardware, including the software overhead. Theoretical analysis and experimental results suggest that the design efficiency scales better for large problem sizes.
The Maintenance of Traditions in Marmosets: Individual Habit, Not Social Conformity? A Field Experiment

Background Social conformity is a cornerstone of human culture because it accelerates and maintains the spread of behaviour within a group. Few empirical studies have investigated the role of social conformity in the maintenance of traditions despite an increasing body of literature on the formation of behavioural patterns in non-human animals. The current report presents a field experiment with free-ranging marmosets (Callithrix jacchus) which investigated whether social conformity is necessary for the maintenance of behavioural patterns within groups or whether individual effects such as habit formation would suffice. Methods Using a two-action apparatus, we established alternative behavioural patterns in six family groups composed of 36 individuals. These groups experienced only one technique during a training phase and were thereafter tested with two techniques available. The monkeys reliably maintained the trained method over a period of three weeks, despite discovering the alternative technique. Three additional groups were given the same number of sessions, but those 21 individuals could freely choose the method to obtain a reward. In these control groups, an overall bias towards one of the two methods was observed, but animals with a different preference did not adjust towards the group norm. Thirteen of the fifteen animals that discovered both techniques remained with the action with which they were initially successful, independent of the group preference and the type of action (Binomial test: exp. proportion: 0.5, p<0.01). Conclusions The results indicate that the maintenance of behavioural patterns within groups 1) could be explained by the first rewarded manipulation and subsequent habit formation and 2) do not require social conformity as a mechanism. After an initial spread of a behaviour throughout a group, this mechanism may lead to a superficial appearance of conformity without the involvement of such a socially and cognitively complex mechanism. This is the first time that such an experiment has been conducted with free-ranging primates.
Indo-European and Asian origins for Chilean and Pacific chickens revealed by mtDNA

European chickens were introduced into the American continents by the Spanish after their arrival in the 15th century. However, there is ongoing debate as to the presence of pre-Columbian chickens among Amerindians in South America, particularly in relation to Chilean breeds such as the Araucana and Passion Fowl. To understand the origin of these populations, we have generated partial mitochondrial DNA control region sequences from 41 native Chilean specimens and compared them with a previously generated database of ≈1,000 domestic chicken sequences from across the world as well as published Chilean and Polynesian ancient DNA sequences. The modern Chilean sequences cluster closely with haplotypes predominantly distributed among European, Indian subcontinental, and Southeast Asian chickens, consistent with a European genetic origin. A published, apparently pre-Columbian, Chilean specimen and six pre-European Polynesian specimens also cluster with the same European/Indian subcontinental/Southeast Asian sequences, providing no support for a Polynesian introduction of chickens to South America. In contrast, sequences from two archaeological sites on Easter Island group with an uncommon haplogroup from Indonesia, Japan, and China and may represent a genetic signature of an early Polynesian dispersal. Modeling of the potential marine carbon contribution to the Chilean archaeological specimen casts further doubt on claims for pre-Columbian chickens, and definitive proof will require further analyses of ancient DNA sequences and radiocarbon and stable isotope data from archaeological excavations within both Chile and Polynesia.