Miracle-dz/UniFAR-FTUs huggingface dataset:
Reactivation of Latent Cytomegalovirus Infection in Mouse Brain Cells Detected after Transfer to Brain Slice Cultures

ABSTRACT Cytomegalovirus (CMV) is the most significant infectious cause of brain disorders in humans involving the developing brain. It is hypothesized that the brain disorders occur after recurrent reactivation of the latent infection in some kinds of cells in the brains. In order to test this hypothesis, we examined the reactivation of latent murine CMV (MCMV) infection in the mouse brain by transfer to brain slice culture. We infected neonatal and young adult mice intracerebrally with recombinant MCMV in which the lacZ gene was inserted into a late gene. The brains were removed 6 months after infection and used to prepare brain slices that were then cultured for up to 4 weeks. Reactivation of latent infection in the brains was detected by β-galactosidase (β-Gal) staining to assess β-galactosidase expression. Viral replication was also confirmed by the plaque assay. Reactivation was observed in about 75% of the mice infected during the neonatal period 6 months after infection. Unexpectedly, reactivation was also observed in 75% of mice infected as young adults, although the infection ratio in the brain slices was significantly lower than that in neonatally infected mice. β-Gal-positive cells were observed in marginal regions of the brains or immature neural cells in the ventricular walls. Immunohistochemical staining showed that the β-Gal-positive reactivated cells were neural stem or progenitor cells. These results suggest that brain disorders may occur long after infection by reactivation of latent infection in the immature neural cells in the brain.
Selectivity in Visual Areas MT and V 1 Comparison of the Spatial Limits on Direction

[PDF] [Full Text] [Abstract] , December 2, 2010; 10 (14): . J Vis Eugenie Roudaia, Patrick J. Bennett, Allison B. Sekuler and Karin S. Pilz Spatiotemporal properties of apparent motion perception and aging [PDF] [Full Text] [Abstract] , March , 2011; 105 (3): 1199-1211. J Neurophysiol Pinar Boyraz and Stefan Treue area MT Misperceptions of speed are accounted for by the responses of neurons in macaque cortical [PDF] [Full Text] [Abstract] , March 9, 2011; 31 (10): 3894-3903. J. Neurosci. Born Carlos R. Ponce, J. Nicholas Hunter, Christopher C. Pack, Stephen G. Lomber and Richard T. Temporal Area MT Contributions of Indirect Pathways to Visual Response Properties in Macaque Middle [PDF] [Full Text] [Abstract] , January 24, 2012; 12 (1): . J Vis Oliver W. Layton, Ennio Mingolla and N. Andrew Browning presence of independently moving objects A motion pooling model of visually guided navigation explains human behavior in the [PDF] [Full Text] [Abstract] , April 15, 2012; 107 (8): 2163-2184. J Neurophysiol Hyun Ah Lee and Sang-Hun Lee Hierarchy of direction-tuned motion adaptation in human visual cortex
E cient Multi-unit Auctions for Normal Goods

I study e cient multi-unit auction design when bidders have private values, multiunit demands, and non-quasilinear preferences. Without quasilinearity, the Vickrey auction loses its desired incentive and e ciency properties. Instead of assuming that bidders have quasilinear preferences, I assume that bidders have positive wealth effects. This nests cases where bidders are risk averse, face financial constraints, or have budgets. With two bidders, I show that there is a mechanism that retains the desirable properties of the Vickrey auction if and only if bidders have single dimensional types. If bidders have multi-dimensional types, there is no mechanism that satisfies (1) individual rationality, (2) dominant strategy incentive compatibility, (3) ex-post Pareto e ciency, and (4) weak budget balance. When there are more than two bidders, I show that there is no mechanism with desirable incentive and e ciency properties, even if bidders have single dimensional types.
PENGARUH KESADARAN HALAL TERHADAP SIKAP DAN IMPLIKASINYA TERHADAP MINAT BELI ULANG

This study aims to examine the effect of Halal awareness (intrinsic and extrinsic) on attitude and its implication on repurchase intention. The attitude variable in this study is treated as an intevening factor beetween halal awareness and repurchase intention. This study used non probability sampling method by distributing quesionaire to 120 moslem J.Co consumers who ever purchase at least once J.Co product. The result were analyzed by using multiple regression analysis with SPSS program. The result indicates that halal awareness of both intrinsic and extrinsic have negative and significant effects on attitude in-0,270and-0,251. While the variable attitude toward repurchase intention show positive and significant impact in 0,174.The variable attitude absolutly functionate as mediator beetween halal awareness and repurchase intention.
Minimizing User Intervention in Registering 2d Images to 3d Models

This paper proposes a novel technique to speed up the registration of 2D images to 3D models. This problem often arises in the process of digitalization of real objects, because pictures are often taken independently from the 3D geometry. Although there are a number of methods for solving the problem of registration automatically, they all need some further assumptions , so in the most general case the process still requires the user to provide some information about how the image corresponds to geometry, for example providing point-to-point correspondences. We propose a method based on a graph representation where the nodes represent the 2D photos and the 3D object, and arcs encode correspondences, which are either image–to–geometry or image– to–image point pairs. This graph is used to infer new correspondences from the ones specified by the user and from successful alignment of single images and to factually encode the state of the registration process. After each action performed by the user, our system explores the states space to find the shortest path from the current state to a state where all the images are aligned, i.e. a final state and, therefore, guides the user in the selection of further alignment actions for a faster completion of the job. Experiments on empirical data are reported to show the effectiveness of the system in reducing the user workload considerably.
The Immuno-Regulatory Effects of Schisandra chinensis and Its Constituents on Human Monocytic Leukemia Cells

Many diseases occur when the immune system is weakened. Intracellular signals activate immuno-responsive cells to produce cytokines that modulate the immune response. Schisandra chinensis has been used traditionally to treat general fatigue, neurasthenia, and spontaneous sweating. In the present study, the effect of constituents of S. chinensis on cytokine release by human monocytic leukemia cells (THP-1) was tested using microparticle-based flow cytometric analysis. Two major lignans, schizandrin (Sch) and gomisin A (Gom A), were identified and shown to induce interleukin (IL)-8, macrophage inflammatory protein-1β (MIP-1β), and granulocyte-macrophage-colony stimulating factor (GM-CSF) release by THP-1 cells. By reverse transcription polymerase chain reaction (RT-PCR) or quantitative real-time PCR, there was a dose-dependent increase of IL-8, MIP-1β and GM-CSF mRNA levels. Thus, Sch and Gom A from S. chinensis enhance cytokine release by THP-1 cells and this effect occurs through mRNA upregulation. Upregulation of MIP-1β and GM-CSF in particular may have clinical applications. Therefore, S. chinensis may be therapeutically beneficial by promoting humoral and cell-mediated immune responses.
EEG source localization in focal epilepsy: Where are we now?

Electroencephalographic source localization (ESL) by noninvasive means is an area of renewed interest in clinical epileptology. This has been driven by innovations in the computer‐assisted modeling of dipolar and distributed sources for the investigation of focal epilepsy; a process fueled by the ever‐increasing computational power available to researchers for the analysis of scalp EEG recordings. However, demonstration of the validity and clinical utility of these mathematically derived source modeling techniques has struggled to keep pace. This review evaluates the current clinical “fitness’ of ESL as applied to the focal epilepsies by examining some of the key studies performed in the field, with emphasis given to clinical work published in the last five years. In doing so, we discuss why ESL techniques have not made an impact on routine epilepsy practice, underlining some of the current problems and controversies in the field. We conclude by examining where ESL currently sits alongside magnetoencephalography and combined EEG‐functional magnetic resonance imaging in the investigation of focal epilepsy.
A phase 1 multidose study of SGN-30 immunotherapy in patients with refractory or recurrent CD30+ hematologic malignancies.

Phase 1 testing of SGN-30, a chimeric monoclonal antibody for the treatment of CD30(+) malignancies, was conducted in a multicenter study. To explore the safety profile and establish the maximum tolerated dose (MTD), 24 patients with refractory or relapsed Hodgkin lymphoma or CD30(+) non-Hodgkin lymphoma received 6 weekly doses of intravenous SGN-30 at 4 dose levels (2, 4, 8, or 12 mg/kg). Serum concentrations of SGN-30 rose rapidly and were dose dependent. Adverse events were mild, with nausea, fatigue, and fever attributed to study treatment. One episode of hypersensitivity rash was reported. The MTD was not reached. Serious adverse events included herpes zoster (n = 2), influenza, and pneumonia. One patient with cutaneous anaplastic large cell lymphoma (8 mg/kg) achieved a complete response. Six patients, of whom 4 had Hodgkin lymphoma, achieved stable disease with durations ranging from 6 to 16 months. The pharmacokinetic profile of SGN-30 showed a biphasic disposition, and estimated half-lives ranging between 1 to 3 weeks. The 6 weekly infusions of SGN-30 resulted in approximately 2- to 3-fold accumulation in serum exposures consistently across the dose range. These results demonstrate that weekly administration of SGN-30 is safe and has modest clinical activity in patients with CD30(+) tumors. This trial is registered at http://www.ClinicalTrials. gov as no. NCT00051597.
Self-Control, Gender, and Age

Abstract This study of 572 male and 120 female graduates of a boot camp investigates the potency of self-control as a predictor of recidivism in comparison to gender, age, and elements of life-course theory. It also examines whether the effects of self-control on recidivism are commensurate within the categories of gender. Recidivism is defined as a felony conviction or parole violation in a 5-year follow-up period. Cox's Proportional-Hazards Models indicate that self-control, gender, and age are significant predictors of recidivism when they are considered separately, and self-control and gender remain significant predictors when they are analyzed simultaneously. Furthermore, analyses show that low self-control is a stronger predictor of recidivism among men than women. Low self-control is a significant predictor of recidivism after elements of life-course theory are added to an analysis that also includes age and gender. Implications of these findings for self-control theory are discussed.
DC-SSAT: A Divide-and-Conquer Approach to Solving Stochastic Satisfiability Problems Efficiently

We present DC-SSAT, a sound and complete divide-and-conquer algorithm for solving stochastic satisfiability (SSAT) problems that outperforms the best existing algorithm for solving such problems (ZANDER) by several orders of magnitude with respect to both time and space. DC-SSAT achieves this performance by dividing the SSAT problem into subproblems based on the structure of the original instance, caching the viable partial assignments (VPAs) generated by solving these subproblems, and using these VPAs to construct the solution to the original problem. DC-SSAT does not save redundant VPAs and each VPA saved is necessary to construct the solution. Furthermore, DC-SSAT builds a solution that is already human-comprehensible, allowing it to avoid the costly solution rebuilding phase in ZANDER. As a result, DC-SSAT is able to solve problems using, typically, 1-2 orders of magnitude less space than ZANDER, allowing DC-SSAT to solve problems ZANDER cannot solve due to space constraints. And, in spite of its more parsimonious use of space, DCSSAT is typically 1-2 orders of magnitude faster than ZANDER. We describe the DC-SSAT algorithm and present empirical results comparing its performance to that of ZANDER on a set of SSAT problems.
Hierarchical Competition for Downlink Power Allocation in OFDMA Femtocell Networks

This paper considers the problem of downlink power allocation in an orthogonal frequency-division multiple access (OFDMA) cellular network with macrocells underlaid with femtocells. The femto-access points (FAPs) and the macro-base stations (MBSs) in the network are assumed to compete with each other to maximize their capacity under power constraints. This competition is captured in the framework of a Stackelberg game with the MBSs as the leaders and the FAPs as the followers. The leaders are assumed to have foresight enough to consider the responses of the followers while formulating their own strategies. The Stackelberg equilibrium is introduced as the solution of the Stackelberg game, and it is shown to exist under some mild assumptions. The game is expressed as a mathematical program with equilibrium constraints (MPEC), and the best response for a one leader-multiple follower game is derived. The best response is also obtained when a quality-of-service constraint is placed on the leader. Orthogonal power allocation between leader and followers is obtained as a special case of this solution under high interference. These results are used to build algorithms to iteratively calculate the Stackelberg equilibrium, and a sufficient condition is given for its convergence. The performance of the system at a Stackelberg equilibrium is found to be much better than that at a Nash equilibrium.
Stable commutator length of a Dehn twist

It is proved that the stable commutator length of a Dehn twist in the mapping class group is positive and the tenth power of a Dehn twist about a nonseparating simple closed curve is a product of two commutators. As an application a new proof of the fact that the growth rate of a Dehn twist is linear is given.
Microsatellite Instability Confounds Engraftment Analysis of Hematopoietic Stem-cell Transplantation

Polymorphic short tandem-repeat, or microsatellite, loci have been widely used to analyze chimerism status after allogeneic hematopoietic stem-cell transplantation. In molecular diagnostic laboratories, it is recommended to calculate mixed chimerism for at least 2 informative loci and to avoid microsatellite loci on chromosomes with copy number changes. In this report, we show that microsatellite instability observed in 2 patients with acute leukemia may confound chimerism analysis. Interpretation errors may occur even if 2 to 3 loci are analyzed because of length variation in multiple microsatellite loci. Although microsatellite loci with length variation should not be selected for chimerism analysis, the presence of microsatellite instability, like copy number alteration because of aberrant chromosomes, provides evidence of recurrent or residual cancer cells after hematopoietic stem-cell transplantation.
L'intégration des industries de réseaux en Europe: régulation, marché et stratégie

Face aux enjeux de la transition energetique, de la communication, de la mobilite des biens et des personnes, et plus generalement de la competitivite dans un monde globalise, les Etats europeens ont fait le choix de developper les reseaux d'infrastructures necessaires au fonctionnement d'un marche commun. Dans cette perspective, le processus d'integration des industries de reseaux en Europe - ici, les secteurs de l'energie et des transports - se traduit par la formation d'espaces communautaires sans frontieres internes. Generalement analysee du point de vue des mecanismes de marche (market design) et/ou de celui des mecanismes de regulation (regulatory design), cette dynamique semble a premiere vue independante des choix des entreprises. En effet, dans ces deux perspectives, les strategies des entreprises qui participent a ce processus sont le plus souvent ignorees ou, tout au plus, prises comme des reactions aux evolutions de marche et de regulation. Or, nous soutenons ici que les entreprises, par leurs strategies de marche, de structuration de marche et non-marche, participent de facon proactive a l'integration des industries de reseaux en Europe. Ainsi, l'articulation des mecanismes de marche, de regulation et des dynamiques strategiques nous conduits a formuler la question de recherche suivante : comment les entreprises actives sur les industries de reseaux europeennes integrent-elles l'evolution des environnements de marche et de regulation a leur strategie ? D'abord, l'etude des mecanismes institutionnels d'integration du transport aerien et de l'electricite nous a permis de caracteriser l'existence d'un cycle de regulation endogene, a l'origine de la production des paquets legislatifs qui encadrent le processus de restructuration des industries de reseaux. Ensuite, l'analyse des choix strategiques de cooperation et de concurrence dans le secteur ferroviaire nous a conduits a developper un outil d'analyse qualitative des strategies d'alliances - les Sequences Strategiques Multidimensionnelles appliquees aux alliances (SSMA) - qui permet de tenir compte a la fois des phenomenes de regulation et de structuration de marche, mais aussi des interdependances entre les acteurs sur differents marches. Enfin, l'analyse d'un projet d'interconnexion electrique entrepris par un operateur prive nous a amenes a developper le concept de situation strategique, caracterise par une configuration particuliere d'acteurs en interaction, d'espaces strategiques et de temps strategiques. Des lors, la prise en compte des risques lies a la dynamique de regulation et aux transformations des marches suggere que les entreprises sont amenees a developper des strategies sequentielles de court terme, ajustees aux parametres evolutifs des situations strategiques. La these montre ainsi que, loin d'etre reactives, les entreprises faconnent par leurs actions et reactions strategiques les contours de ce que sera le marche europeen de demain.
Towards a framework for algorithm recognition in binary code

Algorithm recognition, which is the problem of verifying whether a program implements a given algorithm, is an important topic in program analysis. We propose an approach for algorithm recognition in binary code. For this paper, we have chosen the Dalvik Virtual Machine (DVM) bytecode. Given an algorithm A that is compiled into a DVM method M0, and a DVM program P that includes a series of methods {M1,. , Mn}, the approach is able to identify those blocks Mi from P that essentially implement the algorithm A. The technique we propose first translates binary code into Horn clauses. Then we consider programs as implementing the same algorithm if their Horn clause representations can be reduced to a single common set of Horn clauses by means of a sequence of transformations.
The Importance of Memory Specificity and Memory Coherence for the Self: Linking Two Characteristics of Autobiographical Memory

Autobiographical memory forms a network of memories about personal experiences that defines and supports well-being and effective functioning of the self in various ways. During the last three decades, there have been two characteristics of autobiographical memory that have received special interest regarding their role in psychological well-being and psychopathology, namely memory specificity and memory coherence. Memory specificity refers to the extent to which retrieved autobiographical memories are specific (i.e., memories about a particular experience that happened on a particular day). Difficulty retrieving specific memories interferes with effective functioning of the self and is related to depression and post-traumatic stress disorder. Memory coherence refers to the narrative expression of the overall structure of autobiographical memories. It has likewise been related to psychological well-being and the occurrence of psychopathology. Research on memory specificity and memory coherence has developed as two largely independent research domains, even though they show much overlap. This raises some important theoretical questions. How do these two characteristics of autobiographical memory relate to each other, both theoretically and empirically? Additionally, how can the integration of these two facilitate our understanding of the importance of autobiographical memory for the self? In this article, we give a critical overview of memory specificity and memory coherence and their relation to the self. We link both features of autobiographical memory by describing some important similarities and by formulating hypotheses about how they might relate to each other. By situating both memory specificity and memory coherence within Conway and Pleydell-Pearce’s Self-Memory System, we make a first attempt at a theoretical integration. Finally, we suggest some new and exciting research possibilities and explain how both research fields could benefit from integration in future research.
Gene profiling reveals specific molecular pathways in the pathogenesis of atherosclerosis and cardiovascular disease in antiphospholipid syndrome, systemic lupus erythematosus and antiphospholipid syndrome with lupus

Objective To identify shared and differential molecular pathways involved in the pathogenesis of atherosclerosis (AT) and cardiovascular disease (CVD) in systemic lupus erythematosus (SLE), primary antiphospholipid syndrome (APS) and APS associated with SLE (APS plus SLE). Methods 129 patients (42 APS, 31 APS plus SLE and 56 SLE) and 61 healthy donors were included. Microarray expression profiling was performed in monocytes. RT-PCR of selected genes and western blot were used to validate microarray data. Clinical and inflammatory parameters were also analysed. Results Compared with controls, 555, 1224 and 518 genes were differentially expressed in monocytes from SLE, APS plus SLE and APS patients, respectively. Approximately 25–30% of differentially expressed genes were related to AT and CVD. Each disease displayed a specific AT/CVD/Inflammation-related gene signature. Compared with SLE, APS showed alterations in mitochondria biogenesis and function and oxidative stress. Besides the interferon signature, found in APS plus SLE and SLE patients, various genes mediating atherosclerotic/inflammatory signalling were also differentially expressed in APS plus SLE. IgG-anticardiolipin (aCL) titres independently predicted both atherosclerotic and thrombosis in APS plus SLE. Moreover, a significant correlation of IgG-aCL titres with mRNA levels of certain inflammatory molecules in monocytes was further noticed. In vitro treatment of monocytes with IgG-aCL promoted an increase in the expression of the genes most significantly changed in APS plus SLE versus healthy donors. Conclusions Gene expression profiling allows the segregation of APS, APS plus SLE and SLE, with specific signatures explaining the pro-atherosclerotic and pro-thrombotic alterations in these highly related autoimmune diseases.