Miracle-dz/UniFAR-FTUs huggingface dataset:
Pacific Asia Conference on Information Systems ( PACIS ) 2006 Examining Factors Influencing Behavioral Intentions to Use Asynchronous Web-Based Language Learning

Over the past few years, the prevalence of web-based applications in school and at home makes learning and teaching through the Internet become an inevitable way in education. With great potentials for enriching all kinds of educational applications, web-based instruction is becoming an impressive apparatus for learning resource delivering. In this study, an asynchronous web-based language learning (AWBLL) system is employed in a vocational-technical college in Taiwan to support undergraduate English as a foreign language (EFL) learning. Drawing on the concepts from theory of reasoned action, technology acceptance model and social cognitive theory, this study proposed a comprehensive model and developed an instrument for measuring students’ intentions to use AWBLL Systems. The research findings indicate that students in EFL show great readiness to and positive intentions towards the system for EFL courses and exposed a possible benefit from its use in the long run. However, they also convey some negative opinions of the AWBLL system, suggesting additional improvement of the relative underlying factors of AWBLL technology. The results can proffer useful suggestions for web-based language learning, as well as serve as instrumental guidelines for web-based system to be effectively implemented with care to avoid attenuating students’ interests
A comparison of the original and simplified Pulmonary Embolism Severity Index

Summary The Pulmonary Embolism Severity Index (PESI) is a validated clinical prognostic model for patients with pulmonary embolism (PE). Recently, a simplified version of the PESI was developed. We sought to compare the prognostic performance of the original and simplified PESI. Using data from 15,531 patients with PE, we compared the proportions of patients classified as low versus higher risk between the original and simplified PESI and estimated 30-day mortality within each risk group. To assess the models’ accuracy to predict mortality, we calculated sensitivity, specificity, and predictive values and likelihood ratios for low-versus higher-risk patients. We also compared the models’ discriminative power by calculating the area under the receiver-operating characteristic curve. The overall 30-day mortality was 9.3%. The original PESI classified a significantly greater proportion of patients as low-risk than the simplified PESI (40.9% vs. 36.8%; p<0.001). Low-risk patients based on the original and simplified PESI had a mortality of 2.3% and 2.7%, respectively. The original and simplified PESI had similar sensitivities (90% vs. 89%), negative predictive values (98% vs. 97%), and negative likelihood ratios (0.23 vs. 0.28) for predicting mortality. The original PESI had a significantly greater discriminatory power than the simplified PESI (area under the ROC curve 0.78 [95% CI: 0.77–0.79] vs. 0.72 [95% CI: 0.71–0.74]; p<0.001). In conclusion, even though the simplified PESI accurately identified patients at low-risk of adverse outcomes, the original PESI classified a higher proportion of patients as low-risk and had a greater discriminatory power than the simplified PESI. Institution where the work was carried out: Division of General Internal Medicine, Bern University Hospital, Bern, Switzerland.
Relationship Satisfaction and Psychological Distress Among Concerned Significant Others of Pathological Gamblers

This study explores correlates of psychological distress and relationship satisfaction among concerned significant others (CSOs) of pathological gamblers. CSOs often seek help in dealing with the gambling problem and are influential in recovery, but little is known about the sources of their distress. A sample of 186 CSOs responded to media announcements offering telephone and bibliotherapy support. In multivariate models, CSOs who were spouses and who were younger reported more personal distress, and higher distress was associated with a greater number of CSO emotional and behavioral consequences. Lower relationship satisfaction was associated with more CSO emotional consequences, fewer gambler consequences, and greater severity of gambling problem. Implications for treatment are discussed.
Oxidative Phosphorylation *

This work is produced by OpenStax-CNX and licensed under the Abstract By the end of this section, you will be able to: • Describe how electrons move through the electron transport chain and what happens to their energy levels • Explain how a proton (H + ) gradient is established and maintained by the electron transport chain You have just read about two pathways in glucose catabolism(cid:22)glycolysis and the citric acid cycle(cid:22)that generate ATP. Most of the ATP generated during the aerobic catabolism of glucose, however, is not generated directly from these pathways. Rather, it is derived from a process that begins with moving electrons through a series of electron transporters that undergo redox reactions. This causes hydrogen ions to accumulate within the matrix space. Therefore, a concentration gradient forms in which hydrogen ions di(cid:27)use out of the matrix space by passing through ATP synthase. The current of hydrogen ions powers the catalytic action of ATP synthase, which phosphorylates ADP, producing ATP.
Monte Carlo characterization of target doses in stereotactic body radiation therapy (SBRT)

To compare finite-size pencil beam/equivalent path-length (FSPB/EPL) and Monte Carlo (MC) SBRT dose computations for serial tomotherapy and to quantitatively assess dose differences between the dose calculation methods. Based on 72 SBRT plans for pulmonary targets, FSPB/EPL, considering the inhomogeneous lung environment, and MC calculations were performed to establish differences between FSPB/EPL predicted dose and MC derived doses. Compared with MC, FSPB/EPL consistently overestimated minimum doses to the clinical target volume and planning target volumes by an average of 18.1±7.15% (range 4 to 33.4%), and 21.9±10.4% (range 1.2 to 45.5%), respectively. The respective mean target dose differences were 15.5±7.4% (2.8–36.4%) and 19.2±7.6% (3.6–40.1%). Deviations from MC doses were lesion size and location dependent, with smaller lesions completely embedded into lung parenchyma being most susceptible. Larger lesion in contact with mediastinum and chest wall showed lesser differences. In comparison with MC dose calculation, FSPB/EPL overestimates doses delivered to pulmonary SBRT targets. The observed dose differences may have impact on local tumor control rates, and may deserve consideration when using fast, but less accurate dose calculation methods.
Umbilical vein testosterone in female infants born to mothers with polycystic ovary syndrome is elevated to male levels

The aetiology of polycystic ovary syndrome (PCOS) is poorly understood, but an intrauterine hyperandrogenic environment has been implicated. This study was designed to assess whether the female offspring of mothers with PCOS are exposed to raised levels of testosterone (T) in utero. In this case–control study, three groups of pregnant women were recruited from the labour ward: PCOS women with a female baby (n = 10, PCOS girls); control women with a female baby (n = 20, control girls) and control women with a male baby (n = 10, control boys). Maternal and umbilical vein (UV) blood was assayed for T levels. UV T in PCOS girls was significantly raised, compared with control girls (p < 0.012). The difference in UV T between PCOS girls and control boys was not significant (p < 0.254). This is the first demonstration of a hyperandrogenic in utero environment in PCOS pregnancies; UV T in female infants is raised to male levels.
Characterization of a KCNB1 variant associated with autism, intellectual disability, and epilepsy

Objective: To perform functional characterization of a potentially pathogenic KCNB1 variant identified by clinical exome sequencing of a proband with a neurodevelopmental disorder that included epilepsy and centrotemporal spikes on EEG. Methods: Whole-exome sequencing identified the KCNB1 variant c.595A>T (p.Ile199Phe). Biochemical and electrophysiologic experiments were performed to determine whether this variant affected protein expression, trafficking, and channel functional properties. Results: Biochemical characterization of the variant suggested normal protein expression and trafficking. Functional characterization revealed biophysical channel defects in assembled homotetrameric and heterotetrameric channels. Conclusions: The identification of the KCNB1 variant c.595A>T (p.Ile199Phe) in a neurodevelopmental disorder that included epilepsy with centrotemporal spikes expands the phenotypic spectrum of epilepsies associated with KCNB1 variants. The KCNB1-I199F variant exhibited partial loss of function relative to the wild-type channel. This defect is arguably less severe than previously reported KCNB1 variants, suggesting the possibility that the degree of KCNB1 protein dysfunction may influence disease severity.
Fetal Bladder Wall Regeneration with a Collagen Biomatrix and Histological Evaluation of Bladder Exstrophy in a Fetal Sheep Model

Objectives: To evaluate histological changes in an animal model for bladder exstrophy and fetal repair of the bladder defect with a molecular-defined dual-layer collagen biomatrix to induce fetal bladder wall regeneration. Methods: In 12 fetal lambs the abdominal wall and bladder were opened by a midline incision at 79 days’ gestation. In 6 of these lambs an uncorrected bladder exstrophy was created by suturing the edges of the opened bladder to the abdominal wall (group 1). The other 6 lambs served as a repair group, where a dual-layer collagen biomatrix was sutured into the bladder wall and the abdominal wall was closed (group 2). A caesarean section was performed at 140 days’ gestation, followed by macroscopic and histological examination. Results: Group 1 showed inflammatory and maturational changes in the mucosa, submucosa and detrusor muscle of all the bladders. In group 2, bladder regeneration was observed, with urothelial coverage, ingrowth of fibroblasts and smooth muscle cells, deposition of collagen, neovascularization and nerve fibre formation. This tissue replaced the collagen biomatrix. No structural changes of the bladder were seen in group 2. Conclusions: The animal model, as in group 1, for bladder exstrophy shows remarkable histological resemblance with the naturally occurring anomaly in humans. This model can be used to develop new methods to salvage or regenerate bladder tissue in bladder exstrophy patients. Fetal bladder wall regeneration with a collagen biomatrix is feasible in this model, resulting in renewed formation of urothelium, blood vessels, nerve fibres, ingrowth of smooth muscle cells and salvage of the native bladder.
Health-related quality of life in neurology.

CONTEXT In a climate of growing concern about costs of health care, professional accountability, and the effectiveness and efficiency of treatment, neurologists should understand measures of health-related quality of life (HRQoL) and appreciate both their values and their limits. OBJECTIVE To provide a critical review of current concepts in the measurement of HRQoL, with particular emphasis on those pertaining to neurologic conditions. DESIGN A selective overview of measurement strategies and specific instruments. SETTING Clinical and research settings. PARTICIPANTS Special attention to people with such conditions as multiple sclerosis and Parkinson disease. MAIN OUTCOME MEASURES The utility and relevance to neurologists of available measures of HRQoL. RESULTS There are both generic and condition- or disease-specific measures of HRQoL. Though many measures do not elicit response or are even offensive to people with such conditions as multiple sclerosis and Parkinson disease, other measures pertain directly to their circumstances and needs. CONCLUSIONS Measures of HRQoL are both meaningful and relevant to neurologists. However, they must be refined-enabled-and used in combinations to address the clinical and existential realities of many neurologic conditions. Arch Neurol. 2000;57:1224-1227
Holographic analysis on deformation and restoration of malaria-infected red blood cells by antimalarial drug

Abstract. Malaria parasites induce morphological, biochemical, and mechanical changes in red blood cells (RBCs). Mechanical variations are closely related to the deformability of individual RBCs. The deformation of various RBCs, including healthy and malaria-infected RBCs (iRBCs), can be directly observed through quantitative phase imaging (QPI). The effects of chloroquine treatment on the mechanical property variation of iRBCs were investigated using time-resolved holographic QPI of single live cells on a millisecond time scale. The deformabilities of healthy RBCs, iRBCs, and drug-treated iRBCs were compared, and the effect of chloroquine on iRBC restoration was experimentally examined. The present results are beneficial to elucidate the dynamic characteristics of iRBCs and the effect of the antimalarial drug on iRBCs.
On the robustness of algebraic STBCs to coefficient quantization

In this paper, we study the robustness of high-rate algebraic space-time block codes (STBCs) to coefficient quantization (CQ) at the transmitter in 2 × 2 MIMO fading channels. In particular, we investigate the impact of CQ on the bit error rates of the Golden code and the Silver code with M-QAM constellations. We assume infinite-precision operations at the receiver. Towards generating the matrix codewords, we find the minimum number of bits needed to represent and perform the arithmetic operations such that the finite-precision versions of these codes provide BER close to their infinite-precision counterparts. We show that the Golden code and the Silver code suffer very slight degradation in the BER performance so long as at least 7-bits and 6-bits are used for 4-QAM constellations, respectively. Also, both codes are shown to need a minimum of 8-bits for 16-QAM constellation. Finally, we propose an example of a full-rate, full-diversity STBC which can be encoded with as low as 3-bits for 4-QAM constellation. The advantages of the proposed code are also discussed.
Telomeric repeat-containing RNA/G-quadruplex-forming sequences cause genome-wide alteration of gene expression in human cancer cells in vivo

Telomere erosion causes cell mortality, suggesting that longer telomeres enable more cell divisions. In telomerase-positive human cancer cells, however, telomeres are often kept shorter than those of surrounding normal tissues. Recently, we showed that cancer cell telomere elongation represses innate immune genes and promotes their differentiation in vivo. This implies that short telomeres contribute to cancer malignancy, but it is unclear how such genetic repression is caused by elongated telomeres. Here, we report that telomeric repeat-containing RNA (TERRA) induces a genome-wide alteration of gene expression in telomere-elongated cancer cells. Using three different cell lines, we found that telomere elongation up-regulates TERRA signal and down-regulates innate immune genes such as STAT1, ISG15 and OAS3 in vivo. Ectopic TERRA oligonucleotides repressed these genes even in cells with short telomeres under three-dimensional culture conditions. This appeared to occur from the action of G-quadruplexes (G4) in TERRA, because control oligonucleotides had no effect and a nontelomeric G4-forming oligonucleotide phenocopied the TERRA oligonucleotide. Telomere elongation and G4-forming oligonucleotides showed similar gene expression signatures. Most of the commonly suppressed genes were involved in the innate immune system and were up-regulated in various cancers. We propose that TERRA G4 counteracts cancer malignancy by suppressing innate immune genes.
Congenital defects of the soft palate in 15 mature horses.

REASONS FOR PERFORMING STUDY Horses, usually foals, with a congenital defect of the soft palate have been reported infrequently, and most reports describe a surgical procedure to repair the defect. Results of conservative management have not been previously reported. OBJECTIVE To describe 15 horses affected with soft palate defects that were presented for examination when mature. STUDY DESIGN Retrospective case series. METHODS Clinical records from horses identified as having been diagnosed with a soft palate defect when older than one year were reviewed retrospectively. Follow-up was obtained wherever possible. RESULTS Nasal discharge, occasional coughing and abnormal respiratory noise at exercise were the most common reasons for presentation. Only one yearling had mild symptoms of aspiration pneumonia. Many were able to perform at least low-intensity ridden activities and 2 Thoroughbreds raced successfully without surgical treatment. Surgical correction was attempted in 3 horses but was only partially successful in 2. The other horses were not treated surgically and no deterioration in severity of clinical signs was reported in the long term. The prevalence of survival in this case series was 100%. CONCLUSIONS AND POTENTIAL RELEVANCE This case series shows that some foals may survive to maturity with substantial congenital defects of the soft palate without displaying severe clinical signs. Given the published high incidence of morbidity and mortality associated with surgical treatment, this case series suggests that a reasonable alternative is to manage such cases conservatively, provided that they are not suffering from severe pneumonia or ill thrift and that their welfare is not compromised.
Merging Ranks from Heterogeneous Internet Sources

Many sources on the Internet and elsewhere rank the objects in query results according to how well these objects match the original query. For example, a real-estate agent might rank the available houses according to how well they match the user's preferred location and price. In this environment, ``meta-brokers'' usually query multiple autonomous, heterogeneous sources that might use varying result-ranking strategies. A crucial problem that a meta-broker then faces is extracting from the underlying sources the top objects for a user query according to the meta-broker's ranking function. This problem is challenging because these top objects might not be ranked high by the sources where they appear. In this paper we discuss strategies for solving this ``meta-ranking'' problem. In particular, we present a condition that a source must satisfy so that a meta-broker can extract the top objects for a query from the source without examining its entire contents. Not only is this condition necessary but it is also sufficient, and we show an efficient algorithm to extract the top objects from sources that satisfy the given condition.
Ameliorating effects of curcumin and vitamin E on diazinon-induced oxidative damage in rat liver and erythrocytes

The aim of this study was to evaluate the protective effects of vitamin E and/or curcumin against diazinon (DZN) (an organophosphorus insecticide)-induced toxicity of blood, liver and erythrocyte markers of male Wistar rats. The exposure of rats to DZN for 21 days provoked significant changes in red blood cell counts and hemoglobin. Results showed that lipid peroxidation increased significantly in DZN-treated rats, as evidenced by high liver and erythrocyte thiobarbituric acid reactive substance levels. Alteration of the antioxidant system in DZN-treated rats was confirmed by the significant decrease in the activity of catalase, glutathione peroxidase and glutathione-S-transferase, accompanied by a decline in reduced glutathione content in both tissues. On the other hand, a significant increase in the activities of plasma aspartate transaminase, alanine transaminase, lactate dehydrogenase and alkaline phosphatase was observed in the rats treated with DZN. However, the administration of vitamin E and curcumin has ameliorated the previous markers. In conclusion, our results indicate that the natural antioxidants like vitamin E and curcumin can effectively lower the erythrocytes and hepatic injuries induced by DZN as monitored by lipid peroxides, antioxidant enzyme activities and sensitive serum enzyme levels.
Mesh Independence of Kleinman--Newton Iterations for Riccati Equations in Hilbert Space

In this paper we consider the convergence of the infinite dimensional version of the Kleinman-Newton algorithm for solving the algebraic Riccati operator equation associated with the linear quadratic regulator problem in a Hilbert space. We establish mesh independence for this algorithm and apply the result to systems governed by delay equations. Numerical examples are presented to illustrate the results.
Renal Dysfunction Does Not Alter the Pharmacokinetics or LDL‐Cholesterol Reduction of Atorvastatin

The objective of this study was to determine the effects of renal dysfunction on the steady‐state pharmacokinetics and pharmacodynamics of atorvastatin, a 3‐hydroxy‐3‐methylglutaryl coenzyme A reductase inhibitor. Nineteen subjects with calculated creatinine clearances ranging from 13 mL/min to 143 mL/min were administered 10 mg atorvastatin daily for 2 weeks. Pharmacokinetic parameters and lipid responses were analyzed by regression on calculated creatinine clearance. Correlations between steady‐state atorvastatin pharmacokinetic or pharmacodynamic parameters and creatinine clearance were weak and, in general, did not achieve statistical significance. Although the elimination rate constant, λz (0.579), was significantly correlated with creatinine clearance, neither maximum plasma concentration (Cmax, −0.361) nor oral clearance (Cl/F, 0.306) were; thus, steady‐state exposure is not altered. Renal impairment has no significant effect on pharmacodynamics and pharmacokinetics of atorvastatin.
Noninvasive Arrhythmia Risk Stratification in Idiopathic Dilated Cardiomyopathy: Results of the Marburg Cardiomyopathy Study

Background—Arrhythmia risk stratification with regard to prophylactic implantable cardioverter-defibrillator therapy is a completely unsolved issue in idiopathic dilated cardiomyopathy (IDC). Methods and Results—Arrhythmia risk stratification was performed prospectively in 343 patients with IDC, including analysis of left ventricular (LV) ejection fraction and size by echocardiography, signal-averaged ECG, arrhythmias on Holter ECG, QTc dispersion, heart rate variability, baroreflex sensitivity, and microvolt T-wave alternans. During 52±21 months of follow-up, major arrhythmic events, defined as sustained ventricular tachycardia, ventricular fibrillation, or sudden death, occurred in 46 patients (13%). On multivariate analysis, LV ejection fraction was the only significant arrhythmia risk predictor in patients with sinus rhythm, with a relative risk of 2.3 per 10% decrease of ejection fraction (95% CI, 1.5 to 3.3; P =0.0001). Nonsustained ventricular tachycardia on Holter was associated with a trend toward higher arrhythmia risk (RR, 1.7; 95% CI, 0.9 to 3.3; P =0.11), whereas &bgr;-blocker therapy was associated with a trend toward lower arrhythmia risk (RR, 0.6; 95% CI, 0.3 to 1.2; P =0.13). In patients with atrial fibrillation, multivariate Cox analysis also identified LV ejection fraction and absence of &bgr;-blocker therapy as the only significant arrhythmia risk predictors. Conclusions—Reduced LV ejection fraction and lack of &bgr;-blocker use are important arrhythmia risk predictors in IDC, whereas signal-averaged ECG, baroreflex sensitivity, heart rate variability, and T-wave alternans do not seem to be helpful for arrhythmia risk stratification. These findings have important implications for the design of future studies evaluating prophylactic implantable cardioverter-defibrillator therapy in IDC.