Miracle-dz/UniFAR-FTUs huggingface dataset:
The Relationship between Sleep Complaints, Depression, and Executive Functions on Older Adults

Aim: In this manuscript, we report data on the association between executive functions screened by Frontal Assessment Battery, Five Digit Test and Digit Span with self-reported depressive symptoms and sleep complaints in non-demented older adults. Methods: A total sample of 95 non-demented older adults performed Geriatric Depression Scale short version, Frontal Assessment Battery, Five Digit Test, Digit Span, and clinical interview. We split participants in groups stratified by age according to: young-old (60–69 years of age), old-old (70–79 years), and oldest-old (>80 years) and compared these three groups on the sociodemographic characteristics and executive functions performance. We carried out Poisson regression with robust error variance to verify sleep complaints and depression effects on executive functions performance. Gender, age, years of formal education, use of antidepressants and of benzodiazepines were considered as confounding variables, taking into account executive functions as dependent and sleep complaints and depression as independent variables. Results: Controlling the effect of age, gender, years of formal education, use of benzodiazepines and of antidepressants there was a significant influence of depression in motor programming, inhibitory control, and working memory. Individuals without depression show motor programming scores 68.4% higher, inhibitory control scores 3 times greater and working memory scores also 3 times greater than individuals without depression. There was a significant influence of sleep complaints in phonemic fluency, motor programming, inhibitory control, and working memory. Individuals without sleep complaints show phonemic fluency scores 2 times greater than, motor programming scores 85.9% higher, inhibitory control scores 3 times greater and working memory scores also 3 times greater than individuals without sleep complaints. Conclusions: Sleep complaints are associated with phonemic fluency, motor programming, inhibitory control, and working memory impairment. Depression symptoms presence are associated with motor programming and working memory performances. Depression and sleep complaints interaction would determine worse phonemic fluency, inhibitory control and working memory cognitive performance than these two conditions alone.
The Sexual Experience of Latino Young Adults in College and Their Perceptions of Values About Sex Communicated by Their Parents and Friends

This study examines the values in Latino young adults’ perceptions of messages about sex during their formative years and their current level of sexual exploration and sexual assertiveness. Latino young adults in college (N = 218) rated the prevalence of four types of messages they heard from parents and friends: Sex is only for marriage (procreational), sex is only appropriate in a loving relationship (relational), sex is for pleasure (recreational), and the sexual double standard. Relational sex was most prominent in parental messages; recreational sex was most prominent in friend messages. Women reported more relational sex messages and men reported more recreational sex messages from parents and friends. Fewer procreational sex messages from parents and more recreational sex messages from friends were associated with higher reported levels of sexual exploration and assertiveness. We propose that sexual exploration and assertiveness are behavioral manifestations of individualistic values embedded in sexual discourses among friends and family.
Believing in belonging: An ethnography of young people's constructions of belief

Evidence from a three-year case study suggests that how young people discuss their beliefs reflect where they define and locate legitimate sites of power, meaning and authority. For many young people today, religion is an insufficient source and mode of belief and belonging. The findings discussed here suggest an orientation to family, friends and other social relationships as legitimate and sufficient sites for locating belief, authority and transcendence. I argue that the young people studied do not holds beliefs to be ‘true’, in that they are propositional creed-like statements. Young people have shifted the meaning of belief to describe affective relationships in which they feel they belong to. Such a shift necessitates a relocation of the transcendent to the everyday and social. That shift is particularly evident as young people discuss how they continue their relationships with the deceased loved ones.
Heme oxygenase‐1 related carbon monoxide production and ventricular fibrillation in isolated ischemic/reperfused mouse myocardium

Heme oxygenase‐1 (HO‐1)‐dependent carbon monoxide (CO) production related to reperfusion‐induced ventricular fibrillation (VF) was studied in HO‐1 wild‐type (+/+), heterozygous (+/−), and homozygous (−/−) isolated ischemic/reperfused mouse heart. In HO‐1 homozygous myocardium, under aerobic conditions, HO‐1 enzyme activity, HO‐1 mRNA, and protein expression were not detected in comparison with aerobically perfused wild‐type and heterozygous myocardium. In wild‐type, HO‐1 hetero‐ and homozygous hearts subjected to 20 min ischemia followed by 2 h of reperfusion, the expression of HO‐1 mRNA, protein, and HO‐1 enzyme activity was detected in various degrees. A reduction in the expression of HO‐1 mRNA, protein, and enzyme activity in fibrillated wild‐type and heterozygous myocardium was observed. In reperfused/nonfibrillated wild‐type and heterozygous hearts, a reduction in HO‐1 mRNA, protein expression, and HO‐1 enzyme activity was not observed, indicating that changes in HO‐1 mRNA, protein, and enzyme activity could be related to the development of VF. These changes were reflected in the HO‐1‐related endogenous CO production measured by gas chromatography. In HO‐1 knockout ischemic/reperfused myocardium, all hearts showed VF, and no detection in HO‐1 mRNA, protein, and enzyme activity was observed. Thus, interventions that are able to increase endogenous CO may prevent the development of VF.
Linking preeclampsia and cardiovascular disease later in life

Abstract Preeclampsia (PE), which is defined as new onset hypertension after 20 weeks of pregnancy accompanied by proteinuria, is characterized by inadequate placentation, oxidative stress, inflammation and widespread endothelial dysfunction. A link between PE and long-term risk of cardiovascular disease (CVD) was suggested by retrospective studies, which found that PE was associated with a 2–3-fold risk of CVD later in life, with a 5–7-fold risk in the case of severe and/or early-onset PE. Recently, meta-analyses and prospective studies have confirmed the association between PE and the emergence of an unfavorable CVD risk profile, in particular a 3–5-fold increased prevalence of the metabolic syndrome only 8 years after the index pregnancy. PE and CVD share many risk factors, including obesity, hypertension, dyslipidemia, hypercoagulability, insulin resistance and both entities are characterized by endothelial dysfunction. PE and CVD are complex traits sharing common risk factors and pathophysiological processes, but the genetic link between both remains to be elucidated. However, recent evidence suggests that genetic determinants associated with the metabolic syndrome, inflammation and subsequent endothelial dysfunction are involved. As the evidence now supports that PE represents a risk factor for the emergence of the metabolic syndrome and CVD later in life, the importance of long-term follow-up assessment of CVD risk beginning early in women with a history of PE must be considered and translated into new preventive measures.
Heterogeneity of shale documented by micro‐FTIR and image analysis

In this study, four New Albany Shale Devonian and Mississippian samples, with vitrinite reflectance [Ro] values ranging from 0.55% to 1.41%, were analyzed by micro‐FTIR mapping of chemical and mineralogical properties. One additional postmature shale sample from the Haynesville Shale (Kimmeridgian, Ro = 3.0%) was included to test the limitation of the method for more mature substrates. Relative abundances of organic matter and mineral groups (carbonates, quartz and clays) were mapped across selected microscale regions based on characteristic infrared peaks and demonstrated to be consistent with corresponding bulk compositional percentages. Mapped distributions of organic matter provide information on the organic matter abundance and the connectivity of organic matter within the overall shale matrix. The pervasive distribution of organic matter mapped in the New Albany Shale sample MM4 is in agreement with this shale's high total organic carbon abundance relative to other samples. Mapped interconnectivity of organic matter domains in New Albany Shale samples is excellent in two early mature shale samples having Ro values from 0.55% to 0.65%, then dramatically decreases in a late mature sample having an intermediate Ro of 1.15% and finally increases again in the postmature sample, which has a Ro of 1.41%. Swanson permeabilities, derived from independent mercury intrusion capillary pressure porosimetry measurements, follow the same trend among the four New Albany Shale samples, suggesting that micro‐FTIR, in combination with complementary porosimetric techniques, strengthens our understanding of porosity networks. In addition, image processing and analysis software (e.g. ImageJ) have the capability to quantify organic matter and total organic carbon – valuable parameters for highly mature rocks, because they cannot be analyzed by micro‐FTIR owing to the weakness of the aliphatic carbon–hydrogen signal.
Total bilirubin in nasogastric aspirates: A potential new indicator of postoperative gastrointestinal recovery

Background: The aim of our study was to investigate if total bilirubin (T-bil), amylase (Amy), and sodium (Na) in nasogastric (NG) aspirates can reflect gastrointestinal motility reliably. Materials and Methods: NG aspirates from all laparotomies lasting more than 150 min in children less than 12 months old were studied for 3 months. Color of aspirates and intensity of bowel sounds were graded every 3 h by nursing staff and aspirate samples for measuring T-bil, Amy, and Na were collected independently every 12 h until an oral fluid challenge was tolerated. Results: There were 26 subjects. Mean age at surgery was 5.6 months; mean body weight at surgery was 5.8 kg. No postoperative complications occurred. While there was no reduction in average volume of NG aspirates, color change was subjective, and bowel sounds could not be standardized, T-bil decreased over time (0d: 4.4 mg/dL; 0.5d: 2.7 mg/dL; 1.0d: 1.6 mg/dL; 1.5d: 1.3 mg/dL; 2.0d: 0.4 mg/dL; 2.5d: 0.33 mg/dL; 3.0d: 0.21 mg/dL; 3.5d: 0.15 mg/dL; 4.0d: 0.06 mg/dL; 4.5d: 0.05 mg/dL; 5.0d: 0.02 mg/dL; 5.5d: 0.02 mg/dL; 6.0d: 0.01 mg/dL). Amy and Na were inconclusive. Conclusion: T-bil levels in NG aspirates may be useful as a reliable objective quantitative marker of gastrointestinal motility postoperatively.
Air embolism during neurosurgery in the sitting position. Two case reports.

SUMMARY Two patients undergoing posterior fossa exploration in the sitting position for removal of foramen magnum meningiomata suffered circulatory arrest from air embolism. Both were successfully resuscitated. The mechanism of air embolism is discussed with a review of relevant literature. The disadvantages of spontaneous ventilation are emphasized and it is recommended that controlled positive-positive ventilation should be employed. The means of maintaining a safe venous pressure and other precautions to reduce the incidence of air embolism are discussed. The monitoring techniques available and the treatment of this accident are evaluated.
Anti-Immigrant Party Support and Media Visibility: A Cross-Party, Over-Time Perspective

Explanations of the performance of Western European anti-immigrant parties feature prominently in the literature on electoral behaviour and the mass media have been introduced as an important explanatory variable in these analyses. In this article we advance our understanding of the relationship between mass media news reporting and anti-immigrant party support in three ways. First, we go beyond extant research to consider the visibility of anti-immigrant parties and party leaders in the news, rather than anti-immigration issues more generally. Second, in addition to analysing media effects on a party's popularity we also consider the reverse relationship, the effects of a party's popularity on media coverage of the party. Finally, we analyse the relationships from a cross-party perspective, using time-series analysis for six parties in three countries (Belgium, the Netherlands and Germany) over the past two decades. Our results show strongest support for the effects of party and particularly leader visibility in the news on anti-immigrant party success, rather than the reverse relationship.
A validated, transitional and translational porcine model of hepatocellular carcinoma

Difficult questions are confronting clinicians attempting to improve hepatocellular carcinoma (HCC) outcomes. A large animal model with genetic, anatomical, and physiological similarities to humans is required to transition from mouse models to human clinical trials to address unmet clinical needs. To validate our previously reported inducible porcine cancer model (Oncopig) as a transitional HCC model, Oncopig hepatocyte cultures were transformed using Cre recombinase. The resulting porcine HCC cells (pHCC) expressed oncogenic TP53R167H and KRASG12D, and displayed nuclear pleomorphisms with pale to granular cytoplasm arranged in expanded plates similar to human HCC histopathology. Human HCC transcriptional hallmarks were detected in pHCC cells using RNA-seq, including TERT reactivation, apoptosis evasion, angiogenesis activation, and Wnt signaling activation. Master regulators of gene expression were conserved across Oncopig and 18 human HCC cell lines. pHCC injection into SCID mice resulted in tumors recapitulating human HCC characteristics, including thick trabeculae formation, pseudoacini patterning, and sheets of well-vascularized stroma. Finally, autologous injection of pHCC cells subcutaneously yielded a tumor histologically characterized as Edmondson Steiner (HCC nuclear grade assessment system) grade 2 HCC with trabecular patterning and T-lymphocyte infiltration. These data demonstrate the Oncopig HCC model's utility for improving detection, treatment, and biomarker discovery relevant to human HCC.
Production of xylooligosaccharides in SSF by Bacillus subtilis KCX006 producing β-xylosidase-free endo-xylanase and multiple xylan debranching enzymes

ABSTRACT Xylanase and xylooligosaccharides (XOS) are employed in food and feed industries. Though xylanase production from lignocellulosic materials (LCMs) by solid-state fermentation (SSF) is well known, the XOS formed during growth is not recovered due to its conversion to xylose by β-xylosidase and subsequent bacterial metabolism. A new strain, Bacillus subtilis KCX006, was exceptionally found to synthesize β-xylosidase-free endo-xylanase and multiple xylan debranching enzymes constitutively in the presence of LCMs. Absence of β-xylosidase resulted in accumulation of XOS during growth of KCX006 on LCMs. Therefore, this strain was used for simultaneous production of xylanase and XOS from agro-residues in solid-state fermentation (SSF). Partial purification of XOS from culture supernatant using activated charcoal followed by high-performance liquid chromatography (HPLC) analysis showed xylobiose to xylotetraose formed as the major products. Among various LCM substrates, wheat bran and groundnut oil-cake supported highest xylanase and XOS production at 2158 IU/gdw and 24.92 mg/gdw, respectively. The levels of xylanase and XOS were improved by 1.5-fold (3102 IU/gdw) and 1.9-fold (48 mg/gdw), respectively, by optimization of culture conditions.
Noncanonical spike‐related BOLD responses in focal epilepsy

Till now, most studies of the Blood Oxygen Level‐Dependent (BOLD) response to interictal epileptic discharges (IED) have assumed that its time course matches closely to that of brief physiological stimuli, commonly called the canonical event‐related haemodynamic response function (canonical HRF). Analyses based on that assumption have produced significant response patterns that are generally concordant with prior electroclinical data. In this work, we used a more flexible model of the event‐related response, a Fourier basis set, to investigate the presence of other responses in relation to individual IED in 30 experiments in patients with focal epilepsy. We found significant responses that had a noncanonical time course in 37% of cases, compared with 40% for the conventional, canonical HRF‐based approach. In two cases, the Fourier analysis suggested activations where the conventional model did not. The noncanonical activations were almost always remote from the presumed generator of epileptiform activity. In the majority of cases with noncanonical responses, the noncanonical responses in single‐voxel clusters were suggestive of artifacts. We did not find evidence for IED‐related noncanonical HRFs arising from areas of pathology, suggesting that the BOLD response to IED is primarily canonical. Noncanonical responses may represent a number of phenomena, including artefacts and propagated epileptiform activity. Hum Brain Mapp 2008. © 2007 Wiley‐Liss, Inc.
Silencing bilingualism: a day in a life of a bilingual practitioner

Based on sociocultural theories of learning, this paper draws on findings from a research project ‘a day in a life of a bilingual practitioner’. It explores how two multilingual practitioners in English early years settings supported the learning of young 3–4 year-old children, and their parents and teachers. The paper challenges the current binary opposition of viewing the development and maintenance of home languages and English as existing at two ends of a spectrum in young children's lives and their learning. The data reveal the tensions between this perceived opposition and the silencing of multilingualism enacted by bilingual practitioners in early years settings. We argue that while bilingual practitioners have the potential to draw on their ‘funds of knowledge’, the reality in these classrooms does not allow them to support bilingual learning. The paper concludes that bilingual children's, parents' and practitioners' untapped ‘funds of knowledge’ need to be opened up in order to inform a new bilingual pedagogy in the early years.
Social Inclusion through Volunteering: The Legacy Potential of the 2012 Olympic Games

Considerations of Olympic Games’ legacies have focused on economic benefits, with little consideration given to the potential legacy from the substantial number of volunteers involved. This article examines the experiences of volunteers in a programme established as a legacy of the 2002 Commonwealth Games. Its results challenge the dominant social inclusion discourse in showing that volunteering provides social inclusion benefits beyond employability by enriching volunteers’ lives and empowering them to make new choices. Recognizing and valuing this would enable ‘social inclusion’ programmes promoting volunteering at major events, such as the 2012 Olympics, to broaden their objectives.
Multidimensional and Hierarchical Assessment of School Motivation: Cross‐cultural validation

This study examines the multidimensional and hierarchical structure of achievement goal orientation measured by the Inventory of School Motivation. The instrument consists of eight different scales with 43 survey items (ranging from three to seven items each). Each scale reflects one of eight specific dimensions: task, effort, competition, social power, affiliation, social concern, praise, and token. The study also examines the ability of these eight first‐order factors to define four general second‐order factors—mastery, performance, social factors, and extrinsic factors—as well as one third‐order factor, general motivation. Participants came from seven different cultural groups in high schools in Australia (n = 4,787), Hong Kong (n = 697), the United States (n = 2,660), and Africa (n = 819). Nested confirmatory factor analyses support a multidimensional, hierarchical school motivation construct. The model was invariant across cultural groups. The findings provide a strong theoretical structure and tool for further school motivation research.
Early bilingual acquisition of the voicing contrast in English and Spanish

Abstract A case study of a child acquiring English and Spanish in England between the ages of 1;7 and 2;3 is presented. VOT measurements of utterance-initial stops in English and Spanish were made of productions at ages 1;7, 1;11, and 2;3. Similar measurements of the parents' Spanish speech were made. While the child had developed an adult-like voicing contrast in English by age 2;3, she had not done so in Spanish. However, there were signs of a contrast developing in Spanish, based on small lag differences. Similar lag differences were found in the input. The results are accounted for in terms of the relatively greater acoustic salience of the lag differences in English compared with those in Spanish.
Insulin‐like growth factor‐I protects granule neurons from apoptosis and improves ataxia in weaver mice

Most cerebellar granule neurons in weaver mice undergo premature apoptosis during the first 3 postnatal weeks, subsequently leading to severe ataxia. The death of these granule neurons appears to result from a point mutation in the GIRK2 gene, which encodes a G protein‐activated, inwardly rectifying K+ channel protein. Although the genetic defect was identified, the molecular mechanism by which the mutant K+ channel selectively attacks granule neurons in weaver mice is unclear. Before their demise, weaver granule neurons express abnormally high levels of insulin‐like growth factor (IGF) binding protein 5 (IGFBP5). IGF‐I is essential for the survival of cerebellar neurons during their differentiation. Because IGFBP5 has the capacity to block IGF‐I activity, we hypothesized that reduced IGF‐I availability resulting from excess IGFBP5 accelerates the apoptosis of weaver granule neurons. We found that, consistently with this hypothesis, exogenous IGF‐I partially protected cultured weaver granule neurons from apoptosis by activating Akt and decreasing caspase‐3 activity. To determine whether IGF‐I protects granule neurons in vivo, we cross‐bred weaver mice with transgenic mice that overexpress IGF‐I in the cerebellum. The cerebellar volume was increased in weaver mice carrying the IGF‐I transgene, predominantly because of an increased number of surviving granule neurons. The presence of the IGF‐I transgene resulted in improved muscle strength and a reduction in ataxia, indicating that the surviving granule neurons are functionally integrated into the cerebellar neuronal circuitry. These results confirm our previous suggestion that a lack of IGF‐I activity contributes to apoptosis of weaver granule neurons in vivo and supports IGF‐I's potential therapeutic use in neurodegenerative disease. © 2005 Wiley‐Liss, Inc.