Miracle-dz/UniFAR-FTUs huggingface dataset:
Graded modality-specific specialisation in semantics: A computational account of optic aphasia

A long-standing debate regarding the representation of semantic knowledge is whether such knowledge is represented in a single, amodal system or whether it is organised into multiple subsystems based on modality of input or type of information. The current paper presents a distributed connectionist model of semantics that constitutes a middle ground between these unitary- versus multiple-semantics accounts. In the model, semantic representations develop under the pressure of learning to mediate between multiple input and output modalities in performing various tasks. The system has a topographic bias on learning that favours short connections, leading to a graded degree of modality-specific functional specialisation within semantics. The model is applied to the specific empirical phenomena of optic aphasia--a neuropsychological disorder in which patients exhibit a selective deficit in naming visually presented objects that is not attributable to more generalised impairments in object recognition (visual agnosia) or naming (anomia). As a result of the topographic bias in the model, as well as the relative degrees of systematicity among tasks, damage to connections from vision to regions of semantics near phonology impairs visual object naming far more than visual gesturing or tactile naming, as observed in optic aphasia. Moreover, as in optic aphasia, the system is better at generating the name of an action associated with an object than at generating the name of the object itself, because action naming receives interactive support from the activation of action representations. The ability of the model to account for the pattern of performance observed in optic aphasia across the full range of severity of impairment provides support for the claim that semantic representations exhibit graded functional specialisation rather than being entirely amodal or modality-specific.
Oropharyngeal Aspiration of Burkholderia mallei and Burkholderia pseudomallei in BALB/c Mice

Burkholderia mallei and Burkholderia pseudomallei are potentially lethal pathogens categorized as biothreat agents due, in part, to their ability to be disseminated via aerosol. There are no protective vaccines against these pathogens and treatment options are limited and cumbersome. Since disease severity is greatest when these agents are inhaled, efforts to develop pre- or post-exposure prophylaxis focus largely on inhalation models of infection. Here, we demonstrate a non-invasive and technically simple method for affecting the inhalational challenge of BALB/c mice with B. pseudomallei and B. mallei. In this model, two investigators utilized common laboratory tools such as forceps and a micropipette to conduct and characterize an effective and reproducible inhalational challenge of BALB/c mice with B. mallei and B. pseudomallei. Challenge by oropharyngeal aspiration resulted in acute disease. Additionally, 50% endpoints for B. pseudomallei K96243 and B. mallei ATCC 23344 were nearly identical to published aerosol challenge methods. Furthermore, the pathogens disseminated to all major organs typically targeted by these agents where they proliferated. The pro-inflammatory cytokine production in the proximal and peripheral fluids demonstrated a rapid and robust immune response comparable to previously described murine and human studies. These observations demonstrate that OA is a viable alternative to aerosol exposure.
Supplementation of the maternal diet with tomato powder and marigold extract: effects on the antioxidant system of the developing quail

1. The effects of natural dietary carotenoid supplementation of the maternal diet (tomato powder and marigold extract) on transfer to the egg yolk and on the development of the antioxidant system of the young quail liver in early postnatal life were investigated. 2. Sixty Japanese quail (Coturnix coturnix japonica) were allocated to four treatment groups, each with three replicates consisting of four females and one male each. The quail were fed on one of four different diets for 23 d, each of them based on a low carotenoid, wheat/barley-based control diet. Tomato powder and marigold extract were added at rates of 20 and 2 g/kg to treatments 2 and 3, respectively. Marigold extract and tomato powder were also used in combination in treatment 4 at 2 g marigold + 20 g tomato powder/kg of diet. 3. At 20 weeks of age, 60 eggs from each treatment were collected and placed in an incubator. After hatching, d-old quail from each group were reared (under standard commercial conditions) up to 14 d of age. They were fed on a low-carotenoid commercial diet. After hatch, at 1, 7 and 14 d, the livers of five young quail from each treatment were assessed for total carotenoid concentration and carotenoid profile. 4. Results indicated that lycopene is transferred from the feed to the egg yolk and further to the liver of the developing embryo. Elevated carotenoid concentration in the egg yolk and correspondingly in the liver of newly hatched quail remains significant during first week posthatch. 5. Lutein and lycopene did not affect vitamin E concentration in the egg yolk or liver of the newly hatched quail. A combination of increased concentrations of lycopene and lutein in the egg yolk results in elevated concentrations of coenzyme Q in the liver of the newly hatched quail.
Effect of an enriched drink on cognitive function in frail elderly persons.

BACKGROUND Many elderly persons report that they have difficulties learning new things and remembering names, plans, and conversations. Because decreased cognitive function in elderly persons is potentially related to their poor nutritional status, provision of essential nutrients may improve cognitive function. The authors wanted to determine whether consumption of an enriched drink, including moderate doses of all essential micronutrients, improves cognitive function in frail elderly persons. METHODS Frail, white adults (n=101) who were aged 65 years or older with a body mass index<or=25 kg/m2 were selected for this randomized, double-blind, placebo-controlled trial. They received either an enriched drink or a placebo product for 6 months. Before and after the intervention, participants' cognitive function was assessed (word learning test [WLT], WLT delayed, category fluency [CF] for animals and professions, and recognition memory test for words [RMTW]) and blood biochemical analyses (vitamin B12, homocysteine) were performed. RESULTS Sixty-seven residents completed the study period. After 6 months, significant differences were noted in changes of the WLT (0.9+/-0.3 vs -0.1+/-0.3; p=.014) and CF professions (1.2+/-0.7 vs -0.6+/-0.5; p=.017) in the supplement group (n=34) compared with the placebo group (n=33). No significant differences were observed in WLT delayed, RMTW, and CF animals. The plasma vitamin B12 concentration increased (105+/-50 vs 8 +/-16; p=.003) and the homocysteine concentration decreased (-6.3+/-5.9 vs -0.3+/-2.9; p=.000) in the supplement group compared with the placebo group. CONCLUSIONS This study contributes to the evidence that nutritional supplementation may improve neuropsychological performance in frail elderly persons.
Inner experience in the scanner: can high fidelity apprehensions of inner experience be integrated with fMRI?

To provide full accounts of human experience and behavior, research in cognitive neuroscience must be linked to inner experience, but introspective reports of inner experience have often been found to be unreliable. The present case study aimed at providing proof of principle that introspection using one method, descriptive experience sampling (DES), can be reliably integrated with fMRI. A participant was trained in the DES method, followed by nine sessions of sampling within an MRI scanner. During moments where the DES interview revealed ongoing inner speaking, fMRI data reliably showed activation in classic speech processing areas including left inferior frontal gyrus. Further, the fMRI data validated the participant’s DES observations of the experiential distinction between inner speaking and innerly hearing her own voice. These results highlight the precision and validity of the DES method as a technique of exploring inner experience and the utility of combining such methods with fMRI.
One Screening Magnetic Resonance Imaging Sequence in Evaluation of Chondral and Meniscal Lesions of the Knee − A Pilot Study

This prospective study aimed to evaluate if chondral and meniscal lesions in symptomatic knees of osteoarthritis patients can be reliably identified using only one sagittal dual-echo MRI (Magnetic Resonance Imaging) sequence. MRI was performed on 13 patients after knee arthroscopy due to knee pain and clinically suspected osteoarthritis using a 1.5-Tesla scanner with knee coil and a sagittal dual-echo turbo spin-echo PD (Proton Density)- and T2-weighted sequence. The MRI and arthroscopic findings were then compared. Of 65 articular surfaces, 47 were damaged. For articular cartilage lesions, the overall sensitivity of MRI was 46.8%, specificity 72.2%, and diagnostic accuracy 53.9%, and for meniscal ruptures 81.2%, 66.7%, and 73.1%, respectively. The present study showed that the reliability of screening MRI of knees using only one sagittal dual-echo sequence does not suffice for diagnosis of chondral or meniscal lesions, and should therefore not replace routine knee MRI or diagnostic arthroscopy.
Ion concentrations of PM 10–2.5 and PM 2.5 aerosols over the eastern Mediterranean region: seasonal variation and source identification

Introduction Conclusions References Tables Figures Back Close Abstract Introduction Conclusions References Tables Figures Back Close Abstract The annual averages of particulate matters (PM 10 , PM 10−2.5 (coarse) and PM 2.5 (fine)) in a densely populated area of Beirut were measured and found to be 84±27, 53±20 and 31±9 µg m −3 , respectively. Ion Chromatography (IC) analysis of the collected PM Teflon filters showed that NaCl, CaSO 4 and Ca(NO 3) 2 were predominant in the 5 coarse particles, while (NH 4) 2 SO 4 was the main salt in the fine particles. Using the non destructive Fourier Transform Infra Red-Attenuated Total Reflection (FTIR-ATR) technique, CaCO 3 was determined in the coarse filter. In addition, ATR measurements showed that inorganic salts present in the coarse particles are mostly water insoluble while salts found in fine particles are soluble. Concentrations of nitrates and calcium 10 higher than the ones reported in neighboring Mediterranean countries were good indication of high traffic density and crustal dust abundance in Beirut, respectively. The study of the seasonal variation showed that long-range transport of SO 2 from Eastern and Central Europe, sandy storms coming from Africa and marine aerosols are considered major sources of the determined inorganic ions. Considering the importance of 15 the health and climate impacts of aerosols locally and regionally, this study constitutes a point of reference for eastern Mediterranean transport modeling studies and local regulatory and policy makers.
Transforming Educational Experiences in Low-Income Communities

Full-service community schools aim to reduce educational inequality by addressing the multifaceted needs of low-income children and youth. Critical to this task is the ability of these schools to generate sufficient social capital to provide students, families, and teachers with essential resources. Using data from a qualitative case study, this article explores how social capital was manifested in an urban full-service community elementary school. Findings show that the principal, teachers, and staff were important sources of school-based social capital, which enabled the provision of services to students and families. However, resource scarcity and interethnic tensions threatened the expansion of social capital and the school’s transformative potential. We discuss implications of these findings for the theory, research, and practice of full-service community schools.
Smulation-based Finite Capacity Scheduling: A Case Study

This paper describes the selection and implementation of a simulation-based finite capacity scheduling package for a medium scale manufacturing company, Crane, Inc. of Chicago, Illinois. The paper first discusses the characteristics and constraints of the manufacturing environment at the company and describes a vision of a finite capacity scheduling system aimed at working in this environment. From the vision, system requirements are defined and used to develop evaluation criteria against which alternative commercial packages are then measured, leading to the selection of the most appropriate package. The final two sections of the paper discuss the system implementation process, highlighting the steps needed for success and the lessons learned, and map out the future development of the system within John Crane.
Fine‐needle aspiration cytology of metastatic eccrine porocarcinoma

Eccrine porocarcinoma (EP), although rare, is widely recognized as the most common malignant sweat gland tumor. EP typically grows slowly and usually is cured by surgical excision with clear margins. An elevated mortality rate, however, is observed when regional lymph nodes are involved. We herein describe cytohistologic findings in a case of metastatic EP. An 86‐year‐old man with a history of EP of the left lateral ankle and squamous cell carcinoma in situ (Bowen's disease) of the penis presented with enlarged left inguinal lymph nodes. A superficial fine‐needle aspiration (FNA) was performed and demonstrated a hypercellular sample with discohesive clusters and/or individual tumor cells. The tumor cells were round or oval with most of the cells showing dense, refractile cytoplasm. Intracytoplasmic vacuoles were readily appreciated in some of the cells. Nuclear enlargement, high N/C ratio, nuclear hyperchromasia, bi‐ and multinucleation, and prominent nucleoli were seen. A diagnosis of metastatic eccrine porocarcinoma was rendered. Enlarged retroperitoneal lymph nodes were detected and CT‐guided left retroperitoneal core biopsy was performed 1 week later. The biopsy revealed features consistent with metastatic eccrine porocarcinoma. Diagn. Cytopathol. 2009. © 2009 Wiley‐Liss, Inc.
Minimizing reference count updating with deferred and anchored pointers for functional data structures

Reference counting can be an attractive form of dynamic storage management. It recovers storage promptly and (with a garbage stack instead of a free list) it can be made "real-time"—i.e., all accesses can be performed in constant time. Its major drawbacks are its inability to reclaim cycles, its count storage, and its count update overhead. Update overhead is especially irritating for functional (read-only) data where updates may dirty pristine cache lines and pages.
Globalisation and the dilemmas of income taxation in Australia

Over the past two decades there has been a worldwide fall in statutory corporate tax (CT) rates. Focusing on Australia, this article establishes three empirical facts which challenge much of the existing literature. First, CT competition was the crucial driving force behind CT cuts. Second, policy makers had to abandon tax‐related investment incentives in order to pay for lower CT rates. This broadening of the CT base is costly, because it potentially disadvantages domestic firms and may, over the longer term, erode the CT base. Third, CT cuts have put pressure on the personal income tax base, as low corporate rates provide tax avoidance opportunities for high‐income earners.
Readiness of orang asli communities in royal belum-temengor forest complex, Perak towards sustainable eco-culture tourism (ect) programme

The study develops a new instrument in measuring the validity of the questionnaire in technology banking applications using the Rasch model as an alternative method. Usually, classical method, the Cronbach alpha (α), is used to prove the validity of the instrument. In addition, the Rasch measurement model is also capable of providing guidance to proof quality items to strengthen the legitimacy of the survey instrument. Questionnaire consisting of 28 items and using a 5-level Likert scale with very unimportant to very important as the form of semantic differential was distributed to 223 respondents. Bond and Fox software analysis showed different response patterns to construct items that were measured in the same logit. Findings show the more widespread application of Rasch models would lead to a stronger justification of measurement particularly in cross-cultural studies and whenever measures of individual respondents are of interest. Keywords: sustainable eco-cultural tourism, Royal Belum-Temengor, Orang Asli, forest complex, biodiversity
The Systemic and Local Acute Phase Response following Acute Brain Injury

It is not known whether acute brain injury results in a systemic acute phase response (APR) or whether an APR influences outcome after an insult to the CNS. The present study sought to establish whether brain injury elicits a systemic or local APR. The expression of acute phase protein (APP) mRNA in liver and brain tissues was measured by Taqman reverse transcriptase-polymerase chain reaction after an excitotoxic lesion in the striatum or challenge with a proinflammatory cytokine. N-methyl-D-aspartate (NMDA)–induced brain lesion did not elicit a systemic APR. In contrast, proinflammatory challenge with mouse recombinant interleukin-1β (mrIL-1β) resulted in a significant hepatic APP mRNA expression within 6 hours. Thus, an inflammatory challenge that results in a meningitis leads to a hepatic APR, whereas acute brain injury alone, with no evidence of a meningitis, does not produce an APR. This is surprising because NMDA leads to an increase in endogenous IL-1β synthesis. This suggests that the brain has an endogenous antiinflammatory mechanism, which protects against the spread of inflammation after an acute injury. In the brain, both excitotoxic lesions and proinflammatory challenge resulted in a profound parenchymal upregulation of APP mRNA after 6 and 12 hours in the injected hemisphere. These results suggest that the local APR may play a role as an antiinflammatory mechanism. These findings indicate a potentially pivotal role for peripheral and local APP production on outcome after brain injury.
Low factual understanding and high anxiety about climate warming impedes university students to become sustainability stewards: An Australian case study

Purpose This study, from Western Sydney University, aims to assess the disposition of students towards climate warming (CW) – a key component of sustainability. CW is a global reality. Any human born after February 1985 has never lived in a world that was not constantly warming, yet little is known about how higher education students perceive their future in a warming world. Design/methodology/approach An online survey, split into three parts, was used to deliver benchmark data on (I) personal information, (II) factual knowledge and (III) sentiments related to CW. Findings Gender and age of students significantly influenced their perception of CW. While self-rated understanding of CW was generally high, factual knowledge about CW was low. Few students recognized that CW was already under way, and that it was mainly caused by human activity. The most prominent emotions were fear, sadness and anger, foretelling widespread disempowerment and fear for the future. Research limitations/implications The study was based on a single dataset and survey response was relatively low. However, respondents mirrored the composition of the student community very well. Originality/value This is the first study revealing large psychological distance to the effects of CW in university students from Australia. Combined with the impression of despondence, the present study suggests that higher education in Australia, and possibly elsewhere, is not providing the prerequisite tools tomorrow’s leaders require for meeting societal, environmental and economic challenges caused by CW. Practical ways to erase these blind spots in sustainability literacy are provided, drawing upon established and novel concepts in higher education.
ON DETECTING HALO ASSEMBLY BIAS WITH GALAXY POPULATIONS

The fact that the clustering of dark matter halos depends not only on their mass, but also the formation epoch is a prominent, albeit subtle, feature of the cold dark matter structure formation theory and is known as assembly bias. At low-mass scales ( ∼ 10 12 h − 1 M ⊙ ? > ), early-forming halos are predicted to be more strongly clustered than the late-forming ones. In this study, we aim to robustly detect the signature of assembly bias observationally, making use of formation time indicators of central galaxies in low-mass halos as a proxy for the halo formation history. Weak gravitational lensing is employed to ensure our early- and late-forming halo samples have similar masses, and are free of contamination of satellites from more massive halos. For the two formation time indicators used (resolved star formation history and current specific star formation rate), we do not find convincing evidence of assembly bias. For a pair of early- and late-forming galaxy samples with mean mass M 200 c ≈ 9 × 10 11 h − 1 M ⊙ ? > , the relative bias is 1.00 ± 0.12. We attribute the lack of detection to the possibilities that either the current measurements of these indicators are too noisy, or they do not correlate well with the halo formation history. Alternative proxies for the halo formation history that should perform better are suggested for future studies.
The impact of connection topology and agent size on cooperation in the iterated prisoner's dilemma

This study revisits earlier work, concerning the evolutionary trajectory of agents trained to play iterated prisoner's dilemma on a combinatorial graph. The impact of different connection topologies, used to mediate both the play of prisoner's dilemma and the flow of genes during selection and replacement, is examined. The variety of connection topologies, stored as combinatorial graphs, is revisited and the analysis tools used are substantially improved. A novel tool called the play profile summarizes the distribution of behaviors over multiple replicates of the basic evolutionary algorithm and through multiple evolutionary epochs. The impact of changing the number of states used to encode agents is also examined. Changing the combinatorial graph on which the population resides is found to yield statistically significant differences in the play profiles. Changing the number of states in agents is also found to produce statistically significant differences in behavior. The use of multiple epochs in analysis of agent behavior demonstrates that the distribution of behaviors changes substantially over the course of evolution. The most common pattern is for agents to move toward the cooperative state over time, but this pattern is not universal. Another clear trend is that agents implemented with more states are less cooperative.