Miracle-dz/UniFAR-FTUs huggingface dataset:
Supporting Pupils with Autistic Spectrum Disorders: A Guide for School Support Staff

'More than just a list of practical points.The book is well worth buying and should appeal both to support workers and their managers' - Secondary School SENCo, London 'This book will be of value to all those who support pupils with an autistic spectrum disorder. However, as it tackles the day-to-day practice of teaching and working with such pupils it should be read by teachers too' - Tess Coll, autism outreach teacher 'There can be no doubt that the action suggested by the authors to improve outcomes for pupils with ASD, would benefit the inclusion of all pupils' - Special Needs Information Press 'This book will be a really useful resource for those supporting children with ASDs in a range of schools, both special and mainstream. It uses case study material collected from experience and discussions with staff, to illustrate dilemmas and strategies. It encourages reflection on practice by posing questions at different points. The book also provides many useful references to published materials and websites for readers to follow up and suggests how support assistants can work to become part of the whole staff team' - Dr Glenys Jones, University of Birmingham Specifically designed to provide information and professional guidance for people working in educational support roles, this book focuses on the work carried out by Teaching Assistants in mainstream primary and secondary schools. The book will give them the tools and awareness to work confidently with pupils from across the autistic spectrum, whilst validating their position within a staff team. Using real-life case studies to illustrate common issues faced by support staff within any educational setting, it recogniszes the often tough situations they find themselves in with pupils, and with other members of staff, and will equip them with many basic strategies that will lead to effective working within their setting. 'The chapters are short and well structured. This book will be of value to all those who support pupils with an autistic spectrum disorder. However, as it tackles the day-to-day practice of teaching and working with such pupils it should be read by teachers too' - Special
Instance-Aware Image and Sentence Matching with Selective Multimodal LSTM

Effective image and sentence matching depends on how to well measure their global visual-semantic similarity. Based on the observation that such a global similarity arises from a complex aggregation of multiple local similarities between pairwise instances of image (objects) and sentence (words), we propose a selective multimodal Long Short-Term Memory network (sm-LSTM) for instance-aware image and sentence matching. The sm-LSTM includes a multimodal context-modulated attention scheme at each timestep that can selectively attend to a pair of instances of image and sentence, by predicting pairwise instance-aware saliency maps for image and sentence. For selected pairwise instances, their representations are obtained based on the predicted saliency maps, and then compared to measure their local similarity. By similarly measuring multiple local similarities within a few timesteps, the sm-LSTM sequentially aggregates them with hidden states to obtain a final matching score as the desired global similarity. Extensive experiments show that our model can well match image and sentence with complex content, and achieve the state-of-the-art results on two public benchmark datasets.
Molecular classification of mature aggressive B-cell lymphoma using digital multiplexed gene expression on formalin-fixed paraffin-embedded biopsy specimens.

To the editor: The most frequent mature aggressive B-cell lymphomas are diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphoma (BL). Patients suffering from molecularly defined BL (mBL) but treated with a regimen developed for DLBCL show an unfavorable outcome compared with mBL treated with
Child Maltreatment Among Asian Americans

This article systematically reviews the characteristics of child maltreatment among Asian Americans and provides a theoretical explanatory framework. The reported rate of child maltreatment among Asian Americans is disproportionately low. A high rate of physical abuse and low rates of neglect and sexual abuse are found among Asian American victims. Some protective factors (e.g., the emphasis on family harmony and reputation and the indulgence to infants and toddlers) may lead to low probability of child maltreatment among Asian Americans. Some others (e.g., parental authority and beliefs in physical punishment) may be risk factors of child maltreatment, especially physical abuse. Meanwhile, many other coexisting factors (e.g., children's obedience to parents and families' invisibility to authorities) may prohibit child maltreatment from being disclosed. Therefore, the overall low reported rate of child maltreatment among Asian Americans may be a combination of low incidence and underreporting. Implications for practice and research are discussed.
Designing ad hoc networks with limited infrastructure support

Ad hoc networks based on IEEE 802.11 (Wi-Fi) wireless links are viable for small regions with a few tens of mobile nodes, but such networks suffer from frequently broken routes and low network utilization. We investigate the benefits of adding a few infrastructure nodes to an otherwise ad hoc network to improve its performance. These infrastructure nodes are interconnected among themselves with point-to-point (p2p) links in addition to Wi-Fi capability. To evaluate the benefit of ad hoc networks with mixed broadcast wireless and point to point links, we modify an existing ad hoc routing protocol to automatically discover routes emphasizing p2p links and simulated several ad hoc and mixed networks using the Glomosim simulator. Our results show that adding a small number of point-to-point links makes a significant difference in performance with 2-3 times higher throughput and up to 2-3 times lower packet delays.
Feature combination with Multi-Kernel Learning for fine-grained visual classification

This paper addresses the problem of fine-grained recognition in which local, mid-level features are used for classification. We propose to use the Multi-Kernel Learning framework to learn the relative importance of the features and to select optimal features with regards to the classification performance, in a principled way. Our results show improved classification results on common benchmarks for fine-grained classification, as compared to the best prior state-of-the-art methods. The proposed learning-based combination method also improves the concatenation combination approach which has been the standard practice in combining features so far.
Small region of Rtf1 protein can substitute for complete Paf1 complex in facilitating global histone H2B ubiquitylation in yeast

Histone modifications regulate transcription by RNA polymerase II and maintain a balance between active and repressed chromatin states. The conserved Paf1 complex (Paf1C) promotes specific histone modifications during transcription elongation, but the mechanisms by which it facilitates these marks are undefined. We previously identified a 90-amino acid region within the Rtf1 subunit of Paf1C that is necessary for Paf1C-dependent histone modifications in Saccharomyces cerevisiae. Here we show that this histone modification domain (HMD), when expressed as the only source of Rtf1, can promote H3 K4 and K79 methylation and H2B K123 ubiquitylation in yeast. The HMD can restore histone modifications in rtf1Δ cells whether or not it is directed to DNA by a fusion to a DNA binding domain. The HMD can facilitate histone modifications independently of other Paf1C subunits and does not bypass the requirement for Rad6–Bre1. The isolated HMD localizes to chromatin, and this interaction requires residues important for histone modification. When expressed outside the context of full-length Rtf1, the HMD associates with and causes Paf1C-dependent histone modifications to appear at transcriptionally inactive loci, suggesting that its function has become deregulated. Finally, the Rtf1 HMDs from other species can function in yeast. Our findings suggest a direct and conserved role for Paf1C in coupling histone modifications to transcription elongation.
Does the modern code inspection have value?

For years, it was believed that the value of inspections is in finding and fixing defects early in the development process. Otherwise, the cost to find and fix them later is much higher However in examining code inspection data, we are finding that inspections are beneficial for an additional reason. They make the code easier to understand and change. An analysis of data from a recent code inspection experiment shows that 60% of all issues raised in the code inspections are not problems that could have been uncovered by latter phases of testing or field usage because they have little or nothing to do with the visible execution behavior of the software. Rather they improve the maintainability of the code by making the code conform to coding standards, minimizing redundancies, improving language proficiency, improving safety and portability, and raising the quality of the documentation. We conclude that even if advances in software technology have diminished the value of inspections as a defect detection tool, in most cases, it continues to be of value as a maintenance tool.
Corneal Endothelial Cell Loss After Mitomycin C-augmented Trabeculectomy

PurposeTo determine the effect on the corneal endothelium of mitomycin C (MMC)-augmented trabeculectomy 3 and 12 months after surgery. Patients and MethodsIn a prospective, observational clinical study, 14 eyes of 14 patients with well-established open angle glaucoma were followed for 12 months after MMC-augmented trabeculectomy. We measured the endothelial cell density, the variation in mean cell size, the percentage of hexagonal cells, and the central corneal thickness at baseline and 3 and 12 months postoperatively. ResultsThe mean endothelial cell density was 2525 [standard deviation (SD) 457] cells/mm2 before surgery and 2332 (SD 643) cells/mm2 and 2283 (SD 597) cells/mm2 at 3 and 12 months after surgery, respectively, representing a cell loss of 9.5% (P=0.052) and 10.0% (P=0.027). The cell loss from 3 to 12 months was nonsignificant (P=0.40). After 12 months of follow-up, the variation in mean cell size and the percentage of hexagonal cells had not yet stabilized around the preoperative values. ConclusionsOur results show that significant cell loss occurs during or immediately after MMC-augmented trabeculectomy. However, no progressive cell loss was observed from 3 to 12 months, demonstrating that MMC has no prolonged toxic effect on the corneal endothelium. From 3 to12 months after MMC-augmented trabeculectomy, active endothelial adaptations were taking place.
Women in management and occupational stress

abstract Since the first democratic elections in South Africa, there has been an accelerated move to promote women into managerial and executive positions. The Affirmative Action Policy was introduced to facilitate this process of gender equity amongst managers in the workplace. However, whilst the government has viewed this as positive action, women managers themselves have experienced several sources of work, family and individual stressors. It is against this backdrop that this study examined the stressors that women managers experienced during transformation in the post-apartheid era and strategies used by women managers and organisations to cope with occupational stress. The sample consisted of 30 women managers from diverse racial backgrounds. Both public and private organisations were included in this study. The managers experienced several sources of stress, viz. work stressors, family stressors, personality and individual stressors as well as extra-organisational sources of stress. They manifested stress symptoms at a behavioural, psychological and physiological level. The study found that as stress impacts on all levels of the woman manager's life, the ecological approach to stress management using a multidimensional framework was most appropriate.
Women have better long-term prognosis than men after cardiac resynchronization therapy.

AIMS Cardiac resynchronization therapy (CRT) improves prognosis in patients with moderate-to-severe heart failure, reduced left ventricular ejection fraction, and wide QRS complexes. However, CRT may be under-utilized in women and data on long-term follow-up are still scarce. The aim was to investigate long-term mortality and hospitalization and prognostic impact of gender after CRT. METHODS AND RESULTS Data on 619 consecutive patients (19% women) that received CRT at a single centre between 1998 and 2008 were collected from electronic medical records and national death and hospitalization registries up to 2010. The primary endpoint was death of any cause and the secondary endpoint was combined death of any cause or heart failure hospitalization. Over a mean follow-up of 1320 ± 786 days, 215 (35%) patients reached the primary endpoint and 437 (71%) the secondary endpoint. Overall, 1-, 5-, and 10-year survivals were 91, 63, and 39%, respectively. Female gender was the only independent predictor of all-cause mortality; hazard ratio (HR) 0.44 [95% confidence interval (CI), 0.21-0.90; P= 0.025]. Women also had a trend towards lower risk for the secondary endpoint, HR 0.68 (95% CI, 0.45-1.04; P= 0.072). CONCLUSION In this registry analysis, patients with CRT had similarly high short-term survival to those in controlled trials, and this favourable prognosis was sustained over the long term.Women had lower all-cause mortality than men.
[Surgical treatment for hilar cholangiocarcinoma of Bismuth-Corlette type IV].

OBJECTIVE To investigate the surgical treatment for hilar cholangiocarcinoma(HCCA) of Bismuth-Corlette type IV. METHODS The clinical data of 73 HCCA patients admitted in Southwest Hospital, the Third Military Medical University from January 2002 to December 2008 were analyzed retrospectively. There were 41 males and 32 females, aged from 30 to 84 years old (averaged, 56.8 years old). All patients were diagnosed as hilar mass with hilar biliary obstruction by B-ultrasound, CT, magnetic resonance imaging, endoscopic retrograde cholangiopancreatography, magnetic resonance cholangiopancreatography or percutaneous transhepatic cholangiography, and confirmed by pathological examination in intra-operation and post-operation. Diagnosis of all patients were according to Bismuth-Corlette type IV. RESULTS Fifteen cases underwent percutaneous transhepatic cholangial drainage, stents were implanted in 8 patients. Simple internal drainage was performed on 25 of the 73 patients and 4 with palliative resection. Radical resection was performed on 19 patients. The radical resection rate of HCCA were 26.0%. The 1, 3 years of survival rates were 36.8%, 10.5% respectively. The 1 year survival rate was 6.3% in drainage group. CONCLUSION Radical resection is the potentially curative treatment for HCCA, a sufficient, reasonable use of internal and external drainage would improve the patient's quality of life.
Implantable inlay devices for presbyopia: the evidence to date

By 2020, it is estimated that 2.1 billion people will be presbyopic, and the demand for spectacle independence in this group is growing. This review article provides an overview of the three commercially available corneal inlays for the correction of presbyopia. Safety, efficacy, visual outcomes, and complications are analyzed for all three inlays according to published peer-reviewed data.
Robustness of OFDM signal against temporally localized impulsive noise

We present the theoretical analysis of the bit error rate (BER) performance of single-carrier modulation (SCM) and orthogonal frequency division multiplexing (OFDM) systems under two types of temporally localized impulsive noise environments, namely stationary and bursty impulsive noise. The robustness of OFDM system against impulsive noise is then discussed and compared with that of the SCM system at the same transmission rate. In addition to the common knowledge on OFDM, we show that OFDM system is sometime less robust to impulsive noise than SCM system.
Retinopathy in type 2 diabetic patients with microalbuminuria.

OBJECTIVE To determine the prevalence of retinopathy in type 2 diabetic patients with micoalbuminuria and to evaluate the association of risk factors with prevalence of retinopathy in these patients. MATERIAL AND METHODS A fundus examination of 137 patients suffering from type 2 diabetes mellitus with microalbuminuria was done, with direct ophthalmoscope/ binocular indirect ophthalmoscope after dilating the pupils with 1 % tropicamide eye drops. Retinal changes were graded as no retinopathy, non-proliferative retinopathy, proliferative retinopathy and maculopathy. The association of the duration of diabetes, control of diabetes, hypertension, hyperlipidemia, smoking, obesity and peripheral neuropathy was assessed with the prevalence of retinopathy in these patents. RESULTS The mean age of the patients was 58 years (range 35 - 79 years); 62 % were females, and 49.6 % were Chinese. Diabetic retinopathy was seen in 36.5 % of the patients - non proliferative in 29.2 %, proliferative in 7.3 % and maculopathy in 5.1 % of patients. A longer duration of diabetes (p = 0.002), poor control of diabetes (p = 0.002), presence of hypertension (p = 0.03), and presence of peripheral neuropathy (p = 0.001) were significantly associated with the prevalence of retinopathy; while hyperlipidemia (p = 0.29), smoking (p = 0.43) and obesity (p = 0.43) were not associated with retinopathy. CONCLUSION Retinopathy was seen in 36.5 % of type 2 diabetic patients with microalbuminuria; 7.3 % had proliferative retinopathy and 5.1 % maculopathy (both sight threatening changes). All diabetic patients with microalbuminuria should be screened for retinopathy so that treatment can be instituted in the required patients to prevent ocular morbidity/ blindness.
Cytotoxic Labdane Diterpenes from Hedychium ellipticum Buch.-Ham. ex Sm.

In order to reveal the constituents and their biological activities, we carried out a phytochemical study on Hedychium ellipticum Buch. -Ham. ex Sm. (Zingiberaceae). Ten labdane diterpenoids (1–10) were isolated from the rhizomes of H. ellipticum for the first time. Their structures were identified on the basis of spectroscopic analyses including two-dimensional NMR and comparison with literature data. All of these compounds were evaluated for their antimycobacterial activity against Mycobacterium tuberculosis and cytotoxicity against KB, MCF7, NCI-H187 and Vero cells. The result showed that compounds 1 and 7 exhibited moderate activity against Mycobacterium tuberculosis and compounds 4, 6 and 7 displayed remarkable cytotoxic activity. This is the first report on the presence of all compounds in H. ellipticum and the first time that their structure activity relationship has been discussed.
Plant Products for Innovative Biomaterials in Dentistry

Dental biomaterials and natural products represent two of the main growing research fields, revealing plant-derived compounds may play a role not only as nutraceuticals in affecting oral health, but also in improving physico-chemical properties of biomaterials used in dentistry. Therefore, our aim was to collect all available data concerning the utilization of plant polysaccharides, proteins and extracts rich in bioactive phytochemicals in enhancing performance of dental biomaterials. Although compelling evidences are suggestive of a great potential of plant products in promoting material-tissue/cell interface, to date, only few authors have investigated their use in development of innovative dental biomaterials. A small number of studies have reported plant extract-based titanium implant coatings and periodontal regenerative materials. To the best of our knowledge, this review is the first to deal with this topic, highlighting a general lack of research findings in an interesting field which still needs to be investigated.
First-in-Human Pharmacokinetic and Pharmacodynamic Study of the Dual m-TORC 1/2 Inhibitor AZD2014

Purpose: AZD2014 is a novel, oral, m-TORC 1/2 inhibitor that has shown in vitro and in vivo efficacy across a range of preclinical human cancer models. Experimental Design: A rolling six-dose escalation was performed to define an MTD (part A), and at MTD a further cohort of patients was treated to further characterize toxicities and perform pre- and posttreatment biopsies (part B). AZD2014 was administered orally twice a day continuously. Flow cytometry, ELISA, and immunohistochemistry were used to quantify pharmacodynamic biomarkers. Pharmacokinetic analysis was carried out by mass spectrometry. Results: A total of 56 patients were treated across a dose range of 25 to 100 mg. The MTD was 50 mg twice daily. The dose-limiting toxicities were fatigue and mucositis. At the MTD, the most common adverse events (AE) were fatigue (78%), nausea (51%), and mucositis (49%), but these were equal to or greater than grade 3 in only 5% of patients. Drug levels achieved at the MTD (AUCss 6686 ng·h/mL, Cmax ss 1,664 ng/mL) were consistent with activity in preclinical models. A reduction in p-S6 levels and Ki67 staining was observed in 8 of 8 and 5 of 9 evaluable paired biopsy samples. Partial responses were seen in a patient with pancreatic cancer and a patient with breast cancer, who were found to have a PDGFR and ERBB2 mutation, respectively. Conclusions: The recommended phase II dose for further evaluation of AZD2014 is 50 mg twice daily, and at this dose it has been possible to demonstrate pharmacologically relevant plasma concentrations, target inhibition in tumor, and clinical responses. Clin Cancer Res; 21(15); 3412–9. ©2015 AACR.
A Novel Plant Major Intrinsic Protein in Physcomitrella patens Most Similar to Bacterial Glycerol Channels1

A gene encoding a novel fifth type of major intrinsic protein (MIP) in plants has been identified in the moss Physcomitrella patens. Phylogenetic analyses show that this protein, GlpF-like intrinsic protein (GIP1;1), is closely related to a subclass of glycerol transporters in bacteria that in addition to glycerol are highly permeable to water. A likely explanation of the occurrence of this bacterial-like MIP in P. patens is horizontal gene transfer. The expressed P. patens GIP1;1 gene contains five introns and encodes a unique C-loop extension of approximately 110 amino acid residues that has no obvious similarity with any other known protein. Based on alignments and structural comparisons with other MIPs, GIP1;1 is suggested to have retained the permeability for glycerol but not for water. Studies on heterologously expressed GIP1;1 in Xenopus laevis oocytes confirm the predicted substrate specificity. Interestingly, proteins of one of the plant-specific subgroups of MIPs, the NOD26-like intrinsic proteins, are also facilitating the transport of glycerol and have previously been suggested to have evolved from a horizontally transferred bacterial gene. Further studies on localization and searches for GIP1;1 homologs in other plants will clarify the function and significance of this new plant MIP.