Miracle-dz/UniFAR-FTUs huggingface dataset:
Phenotypic plasticity of gas exchange pattern and water loss in Scarabaeus spretus (Coleoptera: Scarabaeidae): deconstructing the basis for metabolic rate variation

SUMMARY Investigation of gas exchange patterns and modulation of metabolism provide insight into metabolic control systems and evolution in diverse terrestrial environments. Variation in metabolic rate in response to environmental conditions has been explained largely in the context of two contrasting hypotheses, namely metabolic depression in response to stressful or resource-(e.g. water) limited conditions, or elevation of metabolism at low temperatures to sustain life in extreme conditions. To deconstruct the basis for metabolic rate changes in response to temperature variation, here we undertake a full factorial study investigating the longer- and short-term effects of temperature exposure on gas exchange patterns. We examined responses of traits of gas exchange [standard metabolic rate (SMR); discontinuous gas exchange (DGE) cycle frequency; cuticular, respiratory and total water loss rate (WLR)] to elucidate the magnitude and form of plastic responses in the dung beetle, Scarabaeus spretus. Results showed that short- and longer-term temperature variation generally have significant effects on SMR and WLR. Overall, acclimation to increased temperature led to a decline in SMR (from 0.071±0.004 ml CO2 h–1 in 15°C-acclimated beetles to 0.039±0.004 ml CO2 h–1 in 25°C-acclimated beetles measured at 20°C) modulated by reduced DGE frequency (15°C acclimation: 0.554±0.027 mHz, 20°C acclimation: 0.257±0.030 mHz, 25°C acclimation: 0.208±0.027 mHz recorded at 20°C), reduced cuticular WLRs (from 1.058±0.537 mg h–1 in 15°C-acclimated beetles to 0.900±0.400 mg h–1 in 25°C-acclimated beetles measured at 20°C) and reduced total WLR (from 4.2±0.5 mg h–1 in 15°C-acclimated beetles to 3.1±0.5 mg h–1 in 25°C-acclimated beetles measured at 25°C). Respiratory WLR was reduced from 2.25±0.40 mg h–1 in 15°C-acclimated beetles to 1.60±0.40 mg h–1 in 25°C-acclimated beetles measured at 25°C, suggesting conservation of water during DGE bursts. Overall, this suggests water conservation is a priority for S. spretus exposed to longer-term temperature variation, rather than elevation of SMR in response to low temperature acclimation, as might be expected from a beetle living in a relatively warm, low rainfall summer region. These results are significant for understanding the evolution of gas exchange patterns and trade-offs between metabolic rate and water balance in insects and other terrestrial arthropods.
Genomic structure and chromosome location of the human gene encoding the zinc finger autoantigen ZNF330

We have recently described a novel zinc finger cDNA, ZNF330, which was immunologicaly characterized as a new human autoantigen, highly conserved during evolution from nematodes to humans. The protein was found at the nucleolus and the cytoplasm in interphase and transiently associates with centromeres in mitosis as determined by immunofluorescence analysis. We now describe that the association of ZNF330 with the nucleolus but not with the cytoplasm is RNA-dependent as shown by RNAse treatment of fixed culture cells, since ZNF330 localization was unaffected by DNAse treatment. We also report the cloning, structural organization and chromosome location of the human ZNF330 gene. The gene is comprised of 10 exons and spans approximately 16 kb of genomic DNA. The conserved residues forming nine CXXC motifs are contained in exons 3 to 9. Several major transcription initiation sites were located 126, 124 and 121 bp upstream of the translation initiation codon ATG, as determined by primer extension analysis. The human ZNF330 gene was mapped by FISH to chromosome 4q31.1→q31.2, the site of the FRA4C locus previously described as a common fragile site for acquired chromosome instability in humans.
Exact recovery in the Ising blockmodel

We consider the problem associated to recovering the block structure of an Ising model given independent observations on the binary hypercube. This new model, called the Ising blockmodel, is a perturbation of the mean field approximation of the Ising model known as the Curie-Weiss model: the sites are partitioned into two blocks of equal size and the interaction between those of the same block is stronger than across blocks, to account for more order within each block. We study probabilistic, statistical and computational aspects of this model in the high-dimensional case when the number of sites may be much larger than the sample size.
Borderless Mobility in 5G Outdoor Ultra-Dense Networks

This paper considers borderless 5G ultra-dense networks (UDNs). In particular, a novel scheduling algorithm is proposed that achieves a more uniform distribution of user-throughput than that of the state-of-the-art maximum-throughput (MT) schedulers. The proposed scheduling algorithm also takes the coherence time of the channel into account as well as the impact to the acquired channel state information. A novel radio frame structure that is appropriate for achieving a 1-ms round trip time latency is also proposed. Such a low latency allows one to employ multiuser as well as cooperative multiple input multiple output schemes for mobile users. An evaluation of matched-filter and zero-forcing precoding for mobile users in UDNs is included. The performance of the proposed 5G UDN concept is assessed using a system-level simulator. Extensive numerical results show that the proposed borderless scheduling concept achieves ~77% higher median user-throughput than that of the MT scheduler at the cost of ~17% lower area-throughput. Such results are obtained for a high density of mobile users at velocities of ~50 km/h.
A Phase I First-in-Human Study of Nesvacumab (REGN910), a Fully Human Anti–Angiopoietin-2 (Ang2) Monoclonal Antibody, in Patients with Advanced Solid Tumors

Purpose: Nesvacumab (REGN910) is a fully human immunoglobulin G1 (IgG1) monoclonal antibody that specifically binds and inactivates the Tie2 receptor ligand Ang2 with high affinity, but shows no binding to Ang1. The main objectives of this trial were to determine the safety, tolerability, dose-limiting toxicities (DLT), and recommended phase II dose (RP2D) of nesvacumab. Experimental Design: Nesvacumab was administered intravenously every two weeks with dose escalations from 1 to 20 mg/kg in patients with advanced solid tumors. Results: A total of 47 patients were treated with nesvacumab. No patients in the dose escalation phase experienced DLTs, therefore a maximum tolerated dose (MTD) was not reached. The most common nesvacumab-related adverse events were fatigue (23.4%), peripheral edema (21.3%), decreased appetite, and diarrhea (each 10.6%; all grade ≤ 2). Nesvacumab was characterized by linear kinetics and had a terminal half-life of 6.35 to 9.66 days in a dose-independent manner. Best response by RECIST 1.1 in 43 evaluable patients included 1 partial response (adrenocortical carcinoma) of 24 weeks duration. Two patients with hepatocellular carcinoma had stable disease (SD) > 16 weeks, with tumor regression and >50% decrease in α-fetoprotein. Analyses of putative angiogenesis biomarkers in serum and tumor biopsies were uninformative for treatment duration. Conclusions: Nesvacumab safety profile was acceptable at all dose levels tested. Preliminary antitumor activity was observed in patients with treatment-refractory advanced solid tumors. On the basis of cumulative safety, antitumor activity, pharmacokinetic and pharmacodynamic data, the 20 mg/kg dose was determined to be the RP2D. Clin Cancer Res; 22(6); 1348–55. ©2015 AACR.
In-hospital resource utilization in coronary angioplasty: the impact of increased coronary stenting rates and antiplatelet therapy

BACKGROUND: The technique of coronary stenting has evolved over recent years, with improved stent technology and effective antiplatelet therapies to prevent stent thrombosis. In Europe, reductions in stent and equipment costs have resulted from increased market competition. The impact changes on the in-hospital procedural cost of percutaneous coronary intervention (PCI) in the current clinical setting is not known. METHODS: We compared the initial equipment and pharmaceutical costs of one hundred consecutive, unselected patients undergoing PCI in 1998 to a similar population who underwent PCI in 1994. RESULTS: Similar patient characteristics were noted, yet more complex disease (multivessel, AHA type B2/C lesions) was treated in the 1998 population. The stent utilization rate (83% vs 15%, p < 0.0001) and use of intravenous and/or oral antiplatelet therapy (abciximab, ticlopidine) (64% vs 4%, p < 0.0001) was higher in 1998. Similar angiographic success was achieved in each group with low complication rates. Mean hospital stay was reduced in the 1998 group of these (2.6 - 2.8 vs 4.3 - 3.8 days, p < 0.001). Repeat PCI was required more frequently in the 1994 population (26% vs 9%, p < 0.001). Overall there was no significant difference in the mean equipment cost between the two groups ( 1551 vs 1422, p =ns). CONCLUSION: Despite the widespread use of coronary stenting and antiplatelet therapies there appears to be no difference in current in-hospital equipment costs for PCI compared to 1994. Improved clinical outcomes in the 1998 population imply that stenting is a cost-effective therapy. (Int J Cardiovasc Intervent 2000; 3: 161-165)
Sustainability‐Oriented Innovation: A Systematic Review

This paper is intended as a contribution to the ongoing conceptual development of sustainability‐oriented innovation (SOI) and provides initial guidance on becoming and being sustainable. The authors organize and integrate the diverse body of empirical literature relating to SOI and, in doing so, develop a synthesized conceptual framework onto which SOI practices and processes can be mapped. Sustainability‐oriented innovation involves making intentional changes to an organization's philosophy and values, as well as to its products, processes or practices to serve the specific purpose of creating and realizing social and environmental value in addition to economic returns. A critical reading of previous literature relating to environmental management and sustainability reveals how little attention has been paid to SOI, and what exists is only partial. In a review of 100 scholarly articles and 27 grey sources drawn from the period of the three Earth Summits (1992, 2002 and 2012), the authors address four specific deficiencies that have given rise to these limitations: the meaning of SOI; how it has been conceptualized; its treatment as a dichotomous phenomenon; and a general failure to reflect more contemporary practices. The authors adopt a framework synthesis approach involving first constructing an initial architecture of the landscape grounded in previous studies, which is subsequently iteratively tested, shaped, refined and reinforced into a model of SOI with data drawn from included studies: so advancing theoretical development in the field of SOI.
Simultaneous Depth Reconstruction and Restoration of Noisy Stereo Images using Non-local Pixel Distribution

In this paper, we propose a new algorithm that solves both the stereo matching and the image denoising problem simultaneously for a pair of noisy stereo images. Most stereo algorithms employ L1 or L2 intensity error-based data costs in the MAP-MRF framework by assuming the naive intensity-constancy. These data costs make typical stereo algorithms suffer from the effect of noise severely. In this study, a new robust stereo algorithm to noise is presented that performs the stereo matching and the image de-noising simultaneously. In our approach, we redefine the data cost by two terms. The first term is the restored intensity difference, instead of the observed intensity difference. The second term is the non-local pixel distribution dissimilarity around the matched pixels. We adopted the NL-means (non-local means) algorithm for restoring the intensity value as a function of disparity. And a pixel distribution dissimilarity is calculated by using PMHD (perceptually modified Hausdorff distance). The restored intensity values in each image are determined by inferring optimal disparity map at the same time. Experimental results show that the proposed algorithm is more robust and accurate than other conventional algorithms in both stereo matching and denoising.
Human adipose-derived mesenchymal stem cells in vitro: evaluation of an optimal expansion medium preserving stemness.

BACKGROUND AIMS The potential of cultured adipose-derived stem cells (ASC) in regenerative medicine and new cell therapeutic concepts has been shown recently by many investigations. However, while the method of isolation of ASC from liposuction aspirates depending on plastic adhesion is well established, a standard expansion medium optimally maintaining the undifferentiated state has not been described. METHODS We cultured ASC in five commonly used culture media (two laboratory-made media and three commercially available media) and compared them with a standard medium. We analyzed the effects on cell morphology, proliferation, hepatocyte growth factor (HGF) expression, stem cell marker profile and differentiation potential. Proliferation was measured with a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and a fluorescent assay. Release of HGF was assessed by an immunoassay. Expression of characteristic stem cell-related transcription factors and markers was evaluated by quantitative polymerase chain reaction (qPCR) (Nanog, Sox-2, Rex-1, nestin and Oct-4) and flow cytometry (CD44, CD73, CD90, CD105 and CD166), and differentiation was shown by adipogenic medium. RESULTS The morphology and expansion of ASC were significantly affected by the media used, whereas none of the media influenced the ASC potential to differentiate into adipocytes. Furthermore, two of the media induced an increase in expression of transcription factors, an increased secretion of HGF and a decrease in CD105 expression. CONCLUSIONS Culture of ASC in one of these two media before using the cells in cell therapeutic approaches may have a benefit on their regenerative potential.
The Miseducation of Women

Girls and boys are different. So why do our schools insist on treating them as identical? Bringing together many women's voices, from Bridget Jones to Simone de Beauvoir, Betty Friedan to Germaine Greer, Mr. Tooley challenges education's sacred cows, demanding a radical rethinking of sexual politics and a fairer way forward for women. "This book is.carefully wrought to engage readers who might be coming from very different directions. "-Times Educational Supplement.
Beyond the Entropy Power Inequality, via Rearrangements

A lower bound on the Rényi differential entropy of a sum of independent random vectors is demonstrated in terms of rearrangements. For the special case of Boltzmann-Shannon entropy, this lower bound is better than that given by the entropy power inequality. Several applications are discussed, including a new proof of the classical entropy power inequality and an entropy inequality involving symmetrization of Lévy processes.
Federal Reserve Bank of Dallas Globalization and Monetary Policy Institute Do Banking Shocks Matter for the U.s. Economy?

The quantitative significance of shocks to the financial intermediary (FI) has not received much attention up to now. We estimate a DSGE model with what we describe as chained credit contracts, using Bayesian technique. In the model, credit-constrained FIs intermediate funds from investors to credit-constrained entrepreneurs through two types of credit contract. We find that the shocks to the FIs. net worth play an important role in the investment dynamics, accounting for 17% of its variations. In particular, in the Great Recession, they are the key determinants of the investment declines, accounting for 36% of the variations. Conference on Frontiers in Structural Macroeconomic Modeling, and the staff of the Institute for Monetary and Economic Studies (IMES) and the Bank of Japan for their useful comments. The authors particularly thank Simon Gilchrist and Lawrence Christiano for their encouragement at the outset of this research. The views in this paper are those of the authors and do not necessarily reflect the views of the Bank of Japan, the Federal Reserve Bank of Dallas or the Federal Reserve System.
Process conflict management among Indian software employees

Purpose – The purpose of this paper is to test the possible influence of the Ajzen’s theory of planned behaviour (TPB) in predicting conflict-handling intentions during process conflict episodes. Conflict situations are often to be managed with limited time in software projects. With this cue, the study is conducted in the context of software companies in India. Design/methodology/approach – Five variables of the TPB comprising attitude, injunctive subjective norms, descriptive subjective norm, conflict efficacy (CE) and structural assurance (SA) have been studied in relation to the two standard conflict-handling intentions: integrating and dominating approach. By developing vignettes on process conflict, salient beliefs towards process conflicts were elicited among software employees in India. A questionnaire using Ajzen’s guidelines was administered. Structural equation modelling for 150 responses is used for testing path suitability and significance. Findings – Employees with positive attitude towards .
Yield-award placement optimization for Switched-Capacitor analog integrated circuits

Paralleling square unit capacitors have been commonly used for Switched-Capacitor circuits to achieve higher accurate capacitor ratio. However, the capacitor ratio may be shifted due to the wire interconnection of these unit capacitors. The small capacitor ratio shift may cause a significant yield drop. The ratio shift can be reduced by using extra circuitry to achieve parasitic insensitive design. This study presents a simple a layout modification to alleviate the ratio shift, thus enhancing yield, without requiring extra circuitry.
Online Handwritten Cursive Word Recognition Using Segmentation-Free MRF in Combination with P2DBMN-MQDF

This paper describes an online handwritten English cursive word recognition method using a segmentation-free Markov random field (MRF) model in combination with an offline recognition method which uses pseudo 2D bi-moment normalization (P2DBMN) and modified quadratic discriminant function (MQDF). It extracts feature points along the pen-tip trace from pen-down to pen-up and uses the feature point coordinates as unary features and the differences in coordinates between the neighboring feature points as binary features. Each character is modeled as a MRF and word MRFs are constructed by concatenating character MRFs according to a trie lexicon of words during recognition. Our method expands the search space using a character-synchronous beam search strategy to search the segmentation and recognition paths. This method restricts the search paths from the trie lexicon of words and preceding paths, as well as the lengths of feature points during path search. We also combine it with a P2DBMN-MQDF recognizer that is widely used for Chinese and Japanese character recognition.
A Life in Bits and Bytes: A Portrait of a College Student and Her Life with Digital Media

Background/Context Digital media seem to pervade all aspects of American youth's lives, from communicating with friends and family to learning about the world around them. Many educators and scholars celebrate the new opportunities for learning that Web 2.0 tools present, and empirical evidence suggests that computer-mediated communication positively influences the quality of adolescents’ friendships. Yet, adults are also mindful of the risks associated with youth's digital media activities, including the negative effects of multitasking and the implications for identity development of being perpetually “tethered” to one's friends and family. Focus of Study Because widespread Internet and mobile phone use are still relatively new phenomena, further research is needed to investigate their effects on young people. Existing research indicates that the effects are unlikely to be wholly positive or negative. In this article, the author explores the tension between the promises and perils associated with digital media in the context of one college student's daily experiences. Research Design Using the qualitative method of portraiture, the author examined how one college student uses digital media in her everyday life; her motivations and goals for using various media; and the opportunities and drawbacks she perceives in her daily media use. Conclusions This student's experiences illuminate the always-connected, always-connecting quality of life for today's young people. Her experiences also reveal the complexity of life with digital media, because media both support her connections to people and ideas and give rise to feelings of disconnection and fragmentation. Finally, this portrait highlights the need for and value of nurturing youth's reflective practices and providing them with spaces to engage in sustained reflection.
Effects of heat removal through the hand on metabolism and performance during cycling exercise in the heat.

OBJECTIVE This two-part study tested the hypotheses that the use of a new cooling device, purported to extract heat from the body core through the palm of the hand, would (a) attenuate core temperature rise during submaximal exercise in the heat, thereby suppressing exercise-associated metabolic changes, and (b) facilitate a higher sustained workload, thus shortening the completion time of a time-trial performance test. METHODS In Study 1, 8 male triathletes (age 27.9 +/- 2.0 yrs, mass 77.2 +/- 3.1 kg, VO2peak 59.0 +/- 4.1 ml x min(-1) x kg(-1)) cycled for 1 hr at the same absolute workload (approximately 60% VO2peak) in a heated room (31.9 +/- 0.1 degrees C, 24 +/- 1% humidity) on two occasions counterbalanced for cooling (C) or noncooling (NC). In Study 2, 8 similar subjects (age 26.9 +/- 2.0 yrs, mass 75.2 +/- 3.7 kg, VO2peak 54.1 +/- 3.1 ml x min(-1) x kg(-1)) performed two 30-km cycling time-trial performance tests under the same conditions (C(T), NC(T)). RESULTS In Study 1, cooling attenuated the rise in tympanic temperature (T(TY)) (1.2 +/- 0.2 vs. 1.8 +/- 0.2 degrees C; p < 0.01) and lowered mean oxygen consumption (VO2, 2.4 +/- 0.1 vs. 2.7 +/- 0.1 L x min(-1); p < 0.05) and blood lactate (1.7 +/- 0.2 vs. 2.2 +/- 0.2 mmol x L(-1); p < 0.01) during exercise. There were no significant differences in respiratory exchange ratio (RER), blood glucose, heart rate (HR), face temperature (T(F)), or back temperature (T(B)) between NC and C. In Study 2, time to complete 30 km was 6 +/- 1% less with cooling than without cooling (60.9 +/- 2.0 vs. 64.9 +/- 2.6 min; p < 0.01). During the last 20% of C(T), subjects sustained a workload that was 14 +/- 5% (p = 0.06) higher than NC(T) at the same T(TY) and HR. CONCLUSIONS Heat extraction through the hand during cycle ergometer exercise in the heat can (a) lower T(TY), lactate concentration, and VO2 during a submaximal set-workload test and (b) reduce the time it takes to complete a 30-km time-trial test.