Miracle-dz/UniFAR-FTUs huggingface dataset:
Parabolic weighted norm inequalities and partial differential equations

We investigate parabolic Muckenhoupt weights and functions of bounded mean oscillation (BMO) related to nonlinear parabolic partial differential equations. The main result gives a full characterization of weak and strong type weighted norm inequalities for parabolic forward in time maximal operators. In addition, we give a Jones type factorization result for the parabolic Muckenhoupt weights and a Coifman-Rochberg type characterization of the parabolic BMO from Moser's seminal paper through parabolic Muckenhoupt weights and maximal functions.
Disorders of sex development

Purpose of review The current management of patients with intersex, now designated as disorders of sex development, is presented in the context of updated etiological and outcome data, refined surgical procedures and the need for a multidisciplinary approach. Recent findings The recently published consensus statement, the primary publication cited herein, includes known genetic causes of disorders of sex development, and provides a perspective for clinical evaluation, and medical, surgical and psychological management. The importance of fetal hormone exposure, genital development, gonadal differentiation and potential of fertility, full disclosure and parental involvement in decisions is crucial. All need a sex assignment; recommendations should be based upon what is judged to be the most likely adult gender identity, diagnosis, genital appearance and surgical options, fertility, cultural pressures, family dynamics and social circumstance, with deference given to psychosocial factors when the outcome is unpredictable. Surgery is discouraged for mild genital variations, but surgery during infancy is recommended for those with major genital ambiguity. Summary Even with greater understanding of the genetic causes of disorders of sex development, the complex management of these patients must be individualized, considering all aspects, informing as age-appropriate the parents and patient. Further etiology and outcome studies are needed.
Normal-Based Model for True Power Curves of Wind Turbines

Wind turbine power curves do not consider specific weather conditions, wind shear, turbulence effects of the location where the turbine is going to be installed, or its age. A true power curve is obtained by analyzing data from an installed wind turbine over a year. Here, a model for a true power curve is proposed, considering a normal distribution for each range of wind speed data. Furthermore, a Monte Carlo-based simulation technique is proposed to reproduce data following the normal-based model. The main use of the model is to simulate data to complete lacking real data or to perform long-term assessments. The model was checked with data from two wind turbines at the Sotavento experimental wind farm in the northwest of Spain.
A Time and Motion Study of Peripheral Venous Catheter Flushing Practice Using Manually Prepared and Prefilled Flush Syringes

Peripheral venous catheters (PVCs) are the simplest and most frequently used method for drug, fluid, and blood product administration in the hospital setting. It is estimated that up to 90% of patients in acute care hospitals require a PVC; however, PVCs are associated with inherent complications, which can be mechanical or infectious. There have been a range of strategies to prevent or reduce PVC-related complications that include optimizing patency through the use of flushing. Little is known about the current status of flushing practice. This observational study quantified preparation and administration time and identified adherence to principles of Aseptic Non-Touch Technique and organizational protocol on PVC flushing by using both manually prepared and prefilled syringes.
Re-entrainment of circadian rhythms after phase-shifts of the Zeitgeber.

To describe anabrupt shift of the Zeitgeber sufficiently, it is necessary to indicate whether the phase has been advanced or delayed, for how many hours it has been shifted, and what part of the Zeitgeber has been lengthened or shortened respectively. The entrained circadian system usually follows a shift of the Zeitgeber in the same direction and by an equal amount. However, there can be exceptions to both of these rules: a) an instantaneous 12-h shift of a (symmertric) Zeitgeber always represents a delya (= doubling of one-half of its period). In contrast to this, the gradual re-entrainment of the circadian system can be accompalished by either advances or by delays (Fig. 2), it can occur in both dirctions simultaneously by splitting the rhythmic variable (Fig. 1),or it can represent an apparent advance not distinghushable from a delay ( Fig. 6); b) after complietion of re-entraiment, the phase-angle difference psi between organism and Zeitgeber an differ systematically from the pre-shift psi-value.
Chewing the fat on natural killer T cell development

Natural killer T cells (NKT cells) are selected in the thymus by self-glycolipid antigens presented by CD1d molecules. It is currently thought that one specific component of the lysosomal processing pathway, which leads to the production of isoglobotrihexosylceramide (iGb3), is essential for normal NKT cell development. New evidence now shows that NKT cell development can be disrupted by a diverse range of mutations that interfere with different elements of the lysosomal processing and degradation of glycolipids. This suggests that lysosomal storage diseases (LSDs) in general, rather than one specific defect, can disrupt CD1d antigen presentation, leading to impaired development of NKT cells.
Dependency Parsing of Turkish

The suitability of different parsing methods for different languages is an important topic in syntactic parsing. Especially lesser-studied languages, typologically different from the languages for which methods have originally been developed, pose interesting challenges in this respect. This article presents an investigation of data-driven dependency parsing of Turkish, an agglutinative, free constituent order language that can be seen as the representative of a wider class of languages of similar type. Our investigations show that morphological structure plays an essential role in finding syntactic relations in such a language. In particular, we show that employing sublexical units called inflectional groups, rather than word forms, as the basic parsing units improves parsing accuracy. We test our claim on two different parsing methods, one based on a probabilistic model with beam search and the other based on discriminative classifiers and a deterministic parsing strategy, and show that the usefulness of sublexical units holds regardless of the parsing method. We examine the impact of morphological and lexical information in detail and show that, properly used, this kind of information can improve parsing accuracy substantially. Applying the techniques presented in this article, we achieve the highest reported accuracy for parsing the Turkish Treebank.
Hyperpolarization‐activated cation and T‐type calcium ion channel expression in porcine and human renal pacemaker tissues

Renal pacemaker activity triggers peristaltic upper urinary tract contractions that propel waste from the kidney to the bladder, a process prone to congenital defects that are the leading cause of pediatric kidney failure. Recently, studies have discovered that hyperpolarization‐activated cation (HCN) and T‐type calcium (TTC) channel conductances underlie murine renal pacemaker activity, setting the origin and frequency and coordinating upper urinary tract peristalsis. Here, we determined whether this ion channel expression is conserved in the porcine and human urinary tracts, which share a distinct multicalyceal anatomy with multiple pacemaker sites. Double chromagenic immunohistochemistry revealed that HCN isoform 3 is highly expressed at the porcine minor calyces, the renal pacemaker tissues, whereas the kidney and urinary tract smooth muscle lacked this HCN expression. Immunofluorescent staining demonstrated that HCN+ cells are integrated within the porcine calyx smooth muscle, and that they co‐express TTC channel isoform Cav3.2. In humans, the anatomic structure of the minor calyx pacemaker was assayed via hematoxylin and eosin analyses, and enabled the visualization of the calyx smooth muscle surrounding adjacent papillae. Strikingly, immunofluorescence revealed that HCN3+/Cav3.2+ cells are also localized to the human minor calyx smooth muscle. Collectively, these data have elucidated a conserved molecular signature of HCN and TTC channel expression in porcine and human calyx pacemaker tissues. These findings provide evidence for the mechanisms that can drive renal pacemaker activity in the multi‐calyceal urinary tract, and potential causes of obstructive uropathies.
On the Construction of the Infancy‐Childhood‐Puberty Growth Standard

Karlberg J. (Department of Anatomy, University of Gothenburg, Sweden and the Departments of Pediatrics and Biostatistics, University of North Carolina, Chapel Hill, North Carolina, USA). On the construction of the infancy‐childhood‐puberty growth standard. Acta Paediatr Scand [Suppl] 356: 26, 1989.
Mechanical characteristics and preparation of carbon nanotube fiber-reinforced Ti composite

Carbon nanotubes, a kind of high order fullerenes, offers remarkable electronic as well as mechanical properties, e.g., an extremely high Young’s modulus of TPa order has been reported. This suggests the suitability of carbon nanotubes as novel fiber materials for metal matrix composites. The authors demonstrate that Ti/ nanotube composites show a large increase in hardness and Young’s modulus as compared to pure Ti. This makes the composite an attractive advanced material for future applications.
Chemistry of airborne particles from metallurgical processing

Airborne particles fall into one of three size ranges. The nucleation range consists of nanoparticles created from vapor atom collisions. The decisive parameter for particle size and composition is the supercooling of the vapor. The accumulation range, which comprises particles less than 2 micrometers, consists of particles formed from the collision of smaller primary particles from the nucleation range. The composition of agglomerates and coalesced particles is the same as the bulk vapor composition. Coarse particles, the composition of which is determined by a liquid precursor, are greater than 1 micrometer and solidify from droplets whose sizes are controlled by surface, viscous, and inertial forces. The relationship between size and composition of airborne particles could be seen in welding fume, a typical metallurgical aerosol. This analysis was performed with a cascade impactor and energy dispersive spectrometry with both scanning electron microscopy (SEM-EDS) and scanning transmission electron microscopy (STEM-EDS). Other methods for properly characterizing particles were discussed. In the analysis, less than 10% of the mass of fume particles for various types of gas metal arc welding (GMAW) were coarse, while one-third of flux cored arc welding (FCAW) fume particles were coarse. Coarse particles had a composition closer to that of the welding electrode than did fine particles. Primary particles were not homogeneous. Particles larger than the mean free path of the carrier gas had the same composition as that of the vapor, but for particles 20 to 60 nanometers, smaller particles were more enriched in volatile metals than larger particles were. This was explained by the cooling path along the bubble point line of a binary phase diagram. Particles were not necessarily homogenous internally. Because nanoparticles homogenize quickly, they may form in a metastable state, but will not remain in that state. In this analysis, the presence of multiple stable immiscible phases explains this internal heterogeneity. The knowledge contained herein is important for industries that depend on the properties of nanoparticles, and for manufacturing, where industrial hygiene is important because of respirable particle by-products, such as high-energy-density metallurgical processing. Thesis Supervisor: Dr. Thomas W. Eagar, ScD. P.E. Title: Thomas Lord Professor of Materials Engineering & Materials Systems
Genomic congruence of Indo-European speaking tribes of western India with Dravidian-speaking populations of southern India: A study of 20 autosomal DNA markers

Background: Due to its geographic location, Gujarat has played a major role in assimilation of different cultures with those of the subcontinent of India and is home to a number of Indo-European speaking tribes. Aim: This study examined the genetic structure and extent of gene differentiation in eight Indo-European speaking tribal populations of southern Gujarat in western India. It also determined if there was any residual effect of linguistic and cultural assimilation of Indo-European speaking groups on the genomic profile of the tribes under study. Methods: Twenty autosomal DNA markers (Alu InDels and Restriction Fragment Length Polymorphisms) were analysed. Results and conclusions: Average heterozygosity levels were high and degree of gene differentiation (GST = 2%) was small, indicating that genetic drift may not have played a major role in bringing out a characteristic genetic differentiation in these groups. The genetic structure of the populations revealed that neither of these groups was overtly admixed nor completely isolated. Other analyses undertaken on the population affiliations revealed only a slight influence of Indo-European speaking populations on the tribal groups of Gujarat, but there was an overwhelming influence of Dravidian speaking groups of southern India, suggesting that genetic affinities may not necessarily be dependent on linguistic similarities.
Visual influence on path integration in darkness indicates a multimodal representation of large-scale space

Our ability to return to the start of a route recently performed in darkness is thought to reflect path integration of motion-related information. Here we provide evidence that motion-related interoceptive representations (proprioceptive, vestibular, and motor efference copy) combine with visual representations to form a single multimodal representation guiding navigation. We used immersive virtual reality to decouple visual input from motion-related interoception by manipulating the rotation or translation gain of the visual projection. First, participants walked an outbound path with both visual and interoceptive input, and returned to the start in darkness, demonstrating the influences of both visual and interoceptive information in a virtual reality environment. Next, participants adapted to visual rotation gains in the virtual environment, and then performed the path integration task entirely in darkness. Our findings were accurately predicted by a quantitative model in which visual and interoceptive inputs combine into a single multimodal representation guiding navigation, and are incompatible with a model of separate visual and interoceptive influences on action (in which path integration in darkness must rely solely on interoceptive representations). Overall, our findings suggest that a combined multimodal representation guides large-scale navigation, consistent with a role for visual imagery or a cognitive map.
Gelada vocal sequences follow Menzerath’s linguistic law

Significance Human language follows a variety of structural principles, known as linguistic laws. One of these, Menzerath’s law, states that, the larger the size of the construct (e.g., the size of a word in terms of syllable number), the smaller the size of the individual constituent parts (e.g., syllables). We show for the first time (to our knowledge) that Menzerath’s law also holds in the vocal communication of a nonhuman species. In the gelada (Theropithecus gelada), a primate living in the highlands of Ethiopia, longer vocal sequences produced by adult males were associated with shorter individual calls. This result suggests that general—perhaps universal—principles underpin the structure of vocal communication in our own species and others. Identifying universal principles underpinning diverse natural systems is a key goal of the life sciences. A powerful approach in addressing this goal has been to test whether patterns consistent with linguistic laws are found in nonhuman animals. Menzerath’s law is a linguistic law that states that, the larger the construct, the smaller the size of its constituents. Here, to our knowledge, we present the first evidence that Menzerath’s law holds in the vocal communication of a nonhuman species. We show that, in vocal sequences of wild male geladas (Theropithecus gelada), construct size (sequence size in number of calls) is negatively correlated with constituent size (duration of calls). Call duration does not vary significantly with position in the sequence, but call sequence composition does change with sequence size and most call types are abbreviated in larger sequences. We also find that intercall intervals follow the same relationship with sequence size as do calls. Finally, we provide formal mathematical support for the idea that Menzerath’s law reflects compression—the principle of minimizing the expected length of a code. Our findings suggest that a common principle underpins human and gelada vocal communication, highlighting the value of exploring the applicability of linguistic laws in vocal systems outside the realm of language.
In vitro comparison of working length determination using three different electronic apex locators

Background: The aim of this study was to compare the accuracy of the apex-locating functions of DentaPort ZX, Raypex 5 and Endo Master electronic apex locators (EALs) in vitro. Materials and Methods: Thirty extracted human single-rooted teeth with mature apices were used for the study. The real working length (RWL) was established by subtracting 0.5 mm from the actual root canal length. All teeth were mounted in an alginate model that was especially developed to test the EALs and the teeth were then measured with each EAL. The results were compared with the corresponding RWL, which was subtracted from the electronically determined distance. Data were analyzed using a paired-samples t-test, a Chi-square test and a repeated measure analysis of variance evaluation at the 0.05 level of significance. Results: Statistical analysis showed that no significant difference was found among all EALs (P > 0.05). Conclusion: The accuracy of the EALs was evaluated and all of the devices showed an acceptable determination of electronic working length between the ranges of ±0.5 mm.
The Globular Cluster Systems in the Coma Ellipticals. III. The Unique Case of IC 4051

IC 4051 is a giant E galaxy on the outskirts of the Coma Cluster core. Using archival HST WFPC2 data, we derive the metallicity distribution, luminosity function, and spatial structure of its globular cluster system (GCS). The metallicity distribution derived from the V-I colors has a mean ⟨Fe/H⟩ ≃ -0.3, a near-complete lack of metal-poor clusters, and only a small metallicity gradient with radius. We tentatively suggest that the GCS has two roughly equal metallicity subcomponents, one centered at [Fe/H] ∼ 0.0 and the second at [Fe/H] ∼ -1.0, although their identification is blurred by the photometric uncertainties. The luminosity distribution (globular cluster luminosity function) has the standard Gaussian-like form observed in all other giant E galaxies, with a peak (turnover) at V0 = 27.8, consistent with a Coma distance of 100 Mpc. The radial profiles of both the GCS and the halo light show an unusually steep falloff, which may indicate that the halo of this galaxy has been tidally truncated. Lastly, the specific frequency of the GCS is remarkably large: we find SN = 11 ± 2, at a level that rivals M87 and most others in the central cD-type category, even though IC 4051 is not a cD or brightest cluster elliptical. This galaxy exhibits a combination of GCS characteristics found nowhere else. A formation model consistent with most of the observations would be that this galaxy was subjected to removal of a large fraction of its protogalactic gas shortly after its main phase of globular cluster formation, probably by its first passage through the Coma core. Since then, no significant additions due to accretions or mergers have taken place, in strong contrast to the central Coma galaxy NGC 4874.
Unexpected Accumulation of ncm5U and ncm5s2U in a trm9 Mutant Suggests an Additional Step in the Synthesis of mcm5U and mcm5s2U

Background Transfer RNAs are synthesized as a primary transcript that is processed to produce a mature tRNA. As part of the maturation process, a subset of the nucleosides are modified. Modifications in the anticodon region often modulate the decoding ability of the tRNA. At position 34, the majority of yeast cytosolic tRNA species that have a uridine are modified to 5-carbamoylmethyluridine (ncm5U), 5-carbamoylmethyl-2′-O-methyluridine (ncm5Um), 5-methoxycarbonylmethyl-uridine (mcm5U) or 5-methoxycarbonylmethyl-2-thiouridine (mcm5s2U). The formation of mcm5 and ncm5 side chains involves a complex pathway, where the last step in formation of mcm5 is a methyl esterification of cm5 dependent on the Trm9 and Trm112 proteins. Methodology and Principal Findings Both Trm9 and Trm112 are required for the last step in formation of mcm5 side chains at wobble uridines. By co-expressing a histidine-tagged Trm9p together with a native Trm112p in E. coli, these two proteins purified as a complex. The presence of Trm112p dramatically improves the methyltransferase activity of Trm9p in vitro. Single tRNA species that normally contain mcm5U or mcm5s2U nucleosides were isolated from trm9Δ or trm112Δ mutants and the presence of modified nucleosides was analyzed by HPLC. In both mutants, mcm5U and mcm5s2U nucleosides are absent in tRNAs and the major intermediates accumulating were ncm5U and ncm5s2U, not the expected cm5U and cm5s2U. Conclusions Trm9p and Trm112p function together at the final step in formation of mcm5U in tRNA by using the intermediate cm5U as a substrate. In tRNA isolated from trm9Δ and trm112Δ strains, ncm5U and ncm5s2U nucleosides accumulate, questioning the order of nucleoside intermediate formation of the mcm5 side chain. We propose two alternative explanations for this observation. One is that the intermediate cm5U is generated from ncm5U by a yet unknown mechanism and the other is that cm5U is formed before ncm5U and mcm5U.
Comparison of Stress Distribution of Wave One and Reciproc Instruments Using a Finite Element Analysis

Objective: The aim of this study was to compare and evaluate the stress distribution of two different reciprocating systems (Reciproc R25 and WaveOne Primary) with different cross-sectional geometries under bending or torsional conditions using a finite element model. Materials and Methods: Size # 25.08 of two different NiTi instruments was selected for the study. 3-D finite element models were constructed for each file and mechanical behavior of these files were compared under bending (1 N and 2mm) and torsional (2.5 Nmm and 10°) conditions. Results: Under 1 N bending load, both instruments showed similar mechanical behavior. When a 2 mm deflection applied, Reciproc R25 was more flexible. Torsional tests revealed that WaveOne had lower stress concentrations at 10° rotation. When the angle of rotation increased, Reciproc R25 had lower stress concentration. Conclusion: WaveOne Primary showed comparable flexibility to Reciproc R25 under high bending loads and low torsional forces. *Corresponding author: Dr. Ugur INAN, 19 Mayis University, Faculty of Dentistry, Department of Endodontics, 55139 Kurupelit, Samsun, Turkey, Tel: +90 362 3121919/ 3287 (office); Fax: +90 362 457 60 32; E-mail: ugurinan29@hotmail.com