Miracle-dz/UniFAR-FTUs huggingface dataset:
Animal Cryptochromes: Divergent Roles in Light Perception, Circadian Timekeeping and Beyond

Cryptochromes are evolutionarily related to the light‐dependent DNA repair enzyme photolyase, serving as major regulators of circadian rhythms in insects and vertebrate animals. There are two types of cryptochromes in the animal kingdom: Drosophila‐like CRYs that act as nonvisual photopigments linking circadian rhythms to the environmental light/dark cycle, and vertebrate‐like CRYs that do not appear to sense light directly, but control the generation of circadian rhythms by acting as transcriptional repressors. Some animals have both types of CRYs, while others possess only one. Cryptochromes have two domains, the photolyase homology region (PHR) and an extended, intrinsically disordered C‐terminus. While all animal CRYs share a high degree of sequence and structural homology in their PHR domains, the C‐termini are divergent in both length and sequence identity. Recently, cryptochrome function has been shown to extend beyond its pivotal role in circadian clocks, participating in regulation of the DNA damage response, cancer progression and glucocorticoid signaling, as well as being implicated as possible magnetoreceptors. In this review, we provide a historical perspective on the discovery of animal cryptochromes, examine similarities and differences of the two types of animal cryptochromes and explore some of the divergent roles for this class of proteins.
Using Different Cost Functions to Train Stacked Auto-Encoders

Deep neural networks comprise several hidden layers of units, which can be pre-trained one at a time via an unsupervised greedy approach. A whole network can then be trained (fine-tuned) in a supervised fashion. One possible pre-training strategy is to regard each hidden layer in the network as the input layer of an auto-encoder. Since auto-encoders aim to reconstruct their own input, their training must be based on some cost function capable of measuring reconstruction performance. Similarly, the supervised fine-tuning of a deep network needs to be based on some cost function that reflects prediction performance. In this work we compare different combinations of cost functions in terms of their impact on layer-wise reconstruction performance and on supervised classification performance of deep networks. We employed two classic functions, namely the cross-entropy (CE) cost and the sum of squared errors (SSE), as well as the exponential (EXP) cost, inspired by the error entropy concept. Our results were based on a number of artificial and real-world data sets.
Effect of parenting styles on children's emotional and behavioral problems among different ethnicities of Muslim children in the U.S.

EFFECT OF PARENTING STYLES ON CHILDREN’S EMOTIONAL AND BEHAVIORAL PROBLEMS AMONG DIFFERENT ETHNICITIES OF MUSLIM CHILDREN IN THE U.S. Noor A. Rosli, B.A., M.S. Marquette University, 2014 Parenting styles create different social environments in the lives of children within the home. Many studies have investigated the effects of parenting style on children’s emotional development and behavior (Liem, Cavell, & Lustig, 2010; Pezzella, 2010; Schaffer, Clark, & Jeglic, 2009; Steward & Bond, 2002; Timpano, Keough, Mahaffey, Schmidt, & Abramowitz, 2010) as well as differences in parenting across cultures (Keels, 2009; Paulussen-Hoogeboom, Stams, Hermanns, Peetsma, W Takeuchi & Takeuchi, 2008). The present study focused on associations between parenting style and measures of emotional and behavioral problems in Muslim American children. No statistically significant differences were found in emotional and behavior problems between the various parenting groups. Consistency in parenting was also not associated with emotional and behavioral difficulty scores. Authoritative parenting was found to be the most frequent parenting style among Muslim fathers in the study sample, while authoritarian parenting was the most frequently reported parenting style among the Muslim mothers in the sample.
IBM Research Report Constant-Time Sliding Window Aggregation Kanat Tangwongsan

Sliding-window aggregation is a widely-used approach for extracting insights from the most recent portion of a data stream. Most aggregation operations of interest can be cast as binary operators that are associative, but not necessarily commutative nor invert-ible. However, non-invertible operators are nontrivial to support e ﬃ ciently. The best existing algorithms for this setting require O p log n q aggregation steps per window operation, where n is the window size at that point. This paper presents DABA, a novel algorithm that signiﬁcantly improves upon this time bound, assuming the sliding window has FIFO semantics. DABA requires only O p 1 q aggregation steps, in the worst case, per window operation. As such, DABA asymptotically improves the performance of sliding-window aggregation without re-stricting the operator to be invertible. Furthermore, our experimental results demonstrate that these theoretic improvements hold in practice. DABA is a signiﬁcant improvement over the state-of-the-art for both throughput and latency.
To Love and be Loved: Sexuality and People with Physical Disabilities

People with physical disabilities are stereotyped as asexual, as lacking the same sexual and relationship needs and desires as nondisabled people. Yet people with disabilities are human beings, created in the image of God, and thus are sexual beings with the same capacity to love and be loved as any other human. In this article, the author discusses the sexuality and heterosexual experiences of adults with various physical disabilities. She explores possible effects of disabilities on sexual self-concept, romantic relationships, and sexual activities as well as describes some practical steps that can be taken to remedy specific difficulties. The author also briefly relates some personal experiences as a woman with chronic fatigue syndrome and fibromyalgia who is married to a man with cerebral palsy. Implications for clinical practice are discussed. The author encourages psychotherapists to prepare themselves to respond intelligently and comfortably to the sexual questions and issues raised by their physically disabled clients, regardless of the presenting problem.
Simultaneous entry of oxygen ions originating from the Sun and Earth into the inner magnetosphere during magnetic storms

became observable in the energy window of Polar were transported from the high-latitude magnetopause to the inner magnetosphere when the convection electric field was strong. When the convection electric field was weak, the ions were reflected toward the distant tail. The O 6+ ions that became observable in the energy window of Geotail were sufficiently transported from the low-latitude magnetopause to the near-Earth magnetotail regardless of the strength of the convection electric field. The observational facts may be adequately explained in terms of ion transport paths depending on the convection electric field with different entry points.
Metabolomics Biomarkers for Breast Cancer

Metabolomics represents a more recent addition to the range of omics tools, which are increasingly used in clinical applications. By measuring the composition of small molecules in tissues, blood or urine, it provides a sensitive molecular readout often associated with disease and its states, especially in cancer. Changes in metabolism related to cancer are increasingly well understood and are seen as a major hallmark of cancer. This review covers metabolomics used in human breast cancers, with a focus on its application in clinical diagnostics. There are clear indications that metabolomics could be a useful addition to currently established clinical diagnostic tools for breast cancer, including the possibility to detect cancer and to predict treatment responses and survival rates from blood and tissue samples.
Leveraging Resources Under Threat of Opportunism: Predicting Networking in International Growth

The present paper develops a set of hypotheses designed to predict the intensity of networking in the international growth of new, technology-based firms. The model draws on both the resource-based (or knowledge-based) and contractual views of the firm. The model is empirically tested with data from 86 new, technology-based firms in Finland. Mixed support for the model is found. Pointers for future research are discussed.
Reconciling the Evidence on Serum Homocysteine and Ischaemic Heart Disease: A Meta-Analysis

Background Results from genetic epidemiological studies suggest that raised serum homocysteine is a cause of ischaemic heart disease, but the results of randomised trials suggest otherwise. We aimed to update meta-analyses on each type of study using the latest published data and test a hypothesis based on antiplatelet therapy use in the trials to explain the discrepancy. Methods and Findings Meta-analyses of ischaemic heart disease using (i) 75 studies in which the prevalence of a mutation (CT) in the MTHFR gene (which increases homocysteine) was determined in cases (22,068) and controls (23,618), and (ii) 14 randomised trials (39,597 participants) of homocysteine lowering and ischaemic heart disease events. The summary estimates from the two analyses were compared. Meta-analysis of the MTHFR studies showed a statistically significantly increased risk of ischaemic heart disease in TT compared with CC homozygotes; odds ratio 1.16 (1.04 to 1.29) for a 1.9 µmol/L homocysteine difference (TT minus CC). Meta-analysis of randomised trials showed no significant reduction in IHD risk from folic acid; relative risk 1.00 (0.93 to 1.08), despite a reduction in homocysteine of 3.3 µmol/L. There was a statistically significant difference in risk reduction between the 5 trials with the lowest prevalence of antiplatelet therapy (60% on average, usually aspirin), RR 0.93 (0.84 to 1.05) and the 5 trials with the highest prevalence (91% on average), RR 1.09 (1.00 to 1.19), p = 0.037 for the difference. Conclusion Discordant results from MTHFR studies and randomised trials could be explained by aspirin reducing or negating the anti-platelet effect of lowering homocysteine. On this basis, folic acid would have a role in the primary prevention of ischaemic heart disease, when aspirin is not taken routinely, but not in secondary prevention, when it is routine.
The impact Of LMX to career success Based on the psychology capital perspective

This paper focused on the relationship between LMX and subordinate career success. By employees' psychology capital, author open the black box of the process LMX to subordinate career success. From 312 samples in Beijing IT industry, author used the SEM to test the mediation of employees psychology capital between LMX and career success. The result showed that LMX indicated positive impact on subordinate psychology capital, and subordinate psychology capital indicated positive influence on career success. At last, author gave some advice to management practice for managers.
Automated Design, Implementation, and Evaluation of Arbiter-based PUF on FPGA using Programmable Delay Lines

This paper proposes a novel approach for automated implementation of an arbiter-based physical unclonable function (PUF) on field programmable gate arrays (FPGAs). We introduce a high resolution programmable delay logic (PDL) that is implemented by harnessing the FPGA lookup-table (LUT) internal structure. PDL allows automatic fine tuning of delays that can mitigate the timing skews caused by asymmetries in interconnect routing and systematic variations. To thwart the arbiter metastability problem, we present and analyze methods for majority voting of responses. A method to classify and group challenges into different robustness sets is introduced that enhances the corresponding responses’ stability in the face of operational variations. The trade-off between response stability and response entropy (uniqueness) is investigated through comprehensive measurements. We exploit the correlation between the impact of temperature and power supply on responses and perform less costly power measurements to predict the temperature impact on PUF. The measurements are performed on 12 identical Virtex 5 FPGAs across 9 different accurately controlled operating temperature and voltage supply points. A database of challenge response pairs (CRPs) are collected and made openly available for the research community.
Pigeon circovirus infection: Pathological observations and suggested pathogenesis

Pigeon circovirus infection (PiCV) was diagnosed by light and transmission electron microscopy in 15 birds from five lofts in western France. Histopathological findings were suggestive of primary bursotropism of pigeon circovirus, followed by secondary systemic spread from the bursa of Fabricius, particularly to non-bursal lymphoid organs. The last stage of the disease was associated with various secondary (particularly bacterial) infections. In situ detection of apoptosis in the bursa of Fabricius indicated that PiCV was concomitant with an increase in bursal lymphocytic apoptotic events related to viral infection and leading to severe acquired immunosuppression.
Mammalian target of rapamycin inhibition induces cell cycle arrest in diffuse large B cell lymphoma (DLBCL) cells and sensitises DLBCL cells to rituximab

Diffuse large B‐cell lymphoma (DLBCL) is a common lymphoma entity. Although a significant amount of DLBCL patients can be cured with modern chemotherapeutic regimens, a substantial proportion of patients die because of progressive disease. Therefore, new therapeutic strategies are clearly needed. Inhibitors of mTOR [mammalian target of rapamycin (Rap)] represent a new class of antiproliferative drugs with applications as immunosuppressive and anticancer agents. Extensive safety data exist on the mTOR inhibitor RAD001, which is already approved as an immunosuppressant in organ transplant recipients. Rap and RAD001 inhibited cell cycle progression in DLBCL cells by inducing a G1 arrest without inducing apoptosis. Phosphorylation of the main targets of mTOR, p70 s6 kinase and 4‐EBP‐1 was reduced in cells cultured in the presence of RAD001. Cell cycle arrest was accompanied by reduced phosphorylation of the retinoblastoma protein (RB) as well as reduced expression of cyclin D3 and A in all cell lines. Although the effect of the chemotherapeutic agent vincristine (vin) was not enhanced by RAD001, rituximab‐induced cytotoxicity was augmented in the rituximab‐sensitive cell lines. mTOR inhibition is a promising therapeutic strategy in DLBCL by inducing a G1 arrest and augments rituximab‐induced cytotoxicity. Therefore, combination of these drugs might be an interesting new therapeutic approach in DLBCL patients.
Clap-and-fling mechanism in a hovering insect-like two-winged flapping-wing micro air vehicle

This study used numerical and experimental approaches to investigate the role played by the clap-and-fling mechanism in enhancing force generation in hovering insect-like two-winged flapping-wing micro air vehicle (FW-MAV). The flapping mechanism was designed to symmetrically flap wings at a high flapping amplitude of approximately 192°. The clap-and-fling mechanisms were thereby implemented at both dorsal and ventral stroke reversals. A computational fluid dynamic (CFD) model was constructed based on three-dimensional wing kinematics to estimate the force generation, which was validated by the measured forces using a 6-axis load cell. The computed forces proved that the CFD model provided reasonable estimation with differences less than 8%, when compared with the measured forces. The measurement indicated that the clap and flings at both the stroke reversals augmented the average vertical force by 16.2% when compared with the force without the clap-and-fling effect. In the CFD simulation, the clap and flings enhanced the vertical force by 11.5% and horizontal drag force by 18.4%. The observations indicated that both the fling and the clap contributed to the augmented vertical force by 62.6% and 37.4%, respectively, and to the augmented horizontal drag force by 71.7% and 28.3%, respectively. The flow structures suggested that a strong downwash was expelled from the opening gap between the trailing edges during the fling as well as the clap at each stroke reversal. In addition to the fling phases, the influx of air into the low-pressure region between the wings from the leading edges also significantly contributed to augmentation of the vertical force. The study conducted for high Reynolds numbers also confirmed that the effect of the clap and fling was insignificant when the minimum distance between the two wings exceeded 1.2c (c = wing chord). Thus, the clap and flings were successfully implemented in the FW-MAV, and there was a significant improvement in the vertical force.
Fiber density between rhinal cortex and activated ventrolateral prefrontal regions predicts episodic memory performance in humans

The prefrontal cortex (PFC) is assumed to contribute to goal-directed episodic encoding by exerting cognitive control on medial temporal lobe (MTL) memory processes. However, it is thus far unclear to what extent the contribution of PFC-MTL interactions to memory manifests at a structural anatomical level. We combined functional magnetic resonance imaging and fiber tracking based on diffusion tensor imaging in 28 young, healthy adults to quantify the density of white matter tracts between PFC regions that were activated during the encoding period of a verbal free-recall task and MTL subregions. Across the cohort, the strength of fiber bundles linking activated ventrolateral PFC regions and the rhinal cortex (comprising the peri- and entorhinal cortices) of the MTL correlated positively with free-recall performance. These direct white matter connections provide a basis through which activated regions in the PFC can interact with the MTL and contribute to interindividual differences in human episodic memory.
Investigating the Persuasion Potential of Recommender Systems from a Quality Perspective: An Empirical Study

Recommender Systems (RSs) help users search large amounts of digital contents and services by allowing them to identify the items that are likely to be more attractive or useful. RSs play an important persuasion role, as they can potentially augment the users’ trust towards in an application and orient their decisions or actions towards specific directions. This article explores the persuasiveness of RSs, presenting two vast empirical studies that address a number of research questions. First, we investigate if a design property of RSs, defined by the statistically measured quality of algorithms, is a reliable predictor of their potential for persuasion. This factor is measured in terms of perceived quality, defined by the overall satisfaction, as well as by how users judge the accuracy and novelty of recommendations. For our purposes, we designed an empirical study involving 210 subjects and implemented seven full-sized versions of a commercial RS, each one using the same interface and dataset (a subset of Netflix), but each with a different recommender algorithm. In each experimental configuration we computed the statistical quality (recall and F-measures) and collected data regarding the quality perceived by 30 users. The results show us that algorithmic attributes are less crucial than we might expect in determining the user’s perception of an RS’s quality, and suggest that the user’s judgment and attitude towards a recommender are likely to be more affected by factors related to the user experience. Second, we explore the persuasiveness of RSs in the context of large interactive TV services. We report a study aimed at assessing whether measurable persuasion effects (e.g., changes of shopping behavior) can be achieved through the introduction of a recommender. Our data, collected for more than one year, allow us to conclude that, (1) the adoption of an RS can affect both the lift factor and the conversion rate, determining an increased volume of sales and influencing the user’s decision to actually buy one of the recommended products, (2) the introduction of an RS tends to diversify purchases and orient users towards less obvious choices (the long tail), and (3) the perceived novelty of recommendations is likely to be more influential than their perceived accuracy. Overall, the results of these studies improve our understanding of the persuasion phenomena induced by RSs, and have implications that can be of interest to academic scholars, designers, and adopters of this class of systems.
Sensitivity of human visual cortical area V6 to stereoscopic depth gradients associated with self-motion

The principal visual cue to self-motion (egomotion) is optic flow, which is specified in terms of local 2D velocities in the retinal image without reference to depth cues. However, in general, points near the center of expansion of natural flow fields are distant, whereas those in the periphery are closer, creating gradients of horizontal binocular disparity. To assess whether the brain combines disparity gradients with optic flow when encoding egomotion, stereoscopic gradients were applied to expanding dot patterns presented to observers during functional MRI scanning. The gradients were radially symmetrical, disparity changing as a function of eccentricity. The depth cues were either consistent with egomotion (peripheral dots perceived as near and central dots perceived as far) or inconsistent (the reverse gradient, central dots near, peripheral dots far). The BOLD activity generated by these stimuli was compared in a range of predefined visual regions in 13 participants with good stereoacuity. Visual area V6, in the parieto-occipital sulcus, showed a unique pattern of results, responding well to all optic flow patterns but much more strongly when they were paired with consistent rather than inconsistent or zero-disparity gradients. Of the other areas examined, a region of the precuneus and parietoinsular vestibular cortex also differentiate between consistent and inconsistent gradients, but with weak or suppressive responses. V3A, V7, MT, and ventral intraparietal area responded more strongly in the presence of a depth gradient but were indifferent to its depth-flow congruence. The results suggest that depth and flow cues are integrated in V6 to improve estimation of egomotion.
Perspective: Serious play: teaching medical skills with improvisational theater techniques.

The physician-patient encounter may be structured, but it is never scripted; every physician-patient interaction is to some degree improvised. Both physicians and improvisers must prepare for unpredictability, and the surprising and unrecognized overlap between improvisational theater and medical training and medical practice led the author to develop a seminar that tailors improvisational skills to physician needs, teaching communication, professionalism, and other medical skills through an approach she calls "medical improv. " The author observes that there is no example of this teaching strategy as a recurring part of a medical school curriculum reported in the literature, and she describes the contributions medical improv can make to physician skills. The author reports on medical students' positive response to the medical improv seminar she has taught at Northwestern University Feinberg School of Medicine since 2002: 95% of students anonymously evaluating the seminar from 2002 to 2010 agreed with the statement, "Studying improv could make me a better doctor," and 100% agreed with the statement, "I would recommend this class to other medical students. " The author proposes a medical improv teaching model that other medical schools and hospitals could adapt and adopt.