Miracle-dz/UniFAR-FTUs huggingface dataset:
Microgranular variant of acute promyelocytic leukemia in children.

PURPOSE The microgranular variant (M3v) of acute promyelocytic leukemia (APL) rarely has been reported in a pediatric series of acute nonlymphoblastic leukemia (AnLL). We reviewed the clinical and biologic features of childhood M3v cases in our AnLL series. PATIENTS AND METHODS From January 1970 to January 1991, 11 children with M3v were admitted and treated at our center. A diagnosis was made according to French-American-British (FAB) criteria. Morphologic examination, cytochemical analysis, and immunophenotyping were performed by a single pathologist. From January 1984, the diagnosis was confirmed by cytogenetic and, subsequently, by molecular analysis on frozen material. RESULTS In our series, the overall incidence of children with APL was unusually high, 31.2% of the AnLL and M3v constituted one case in every four cases of APL. Even restriction of the analysis to the time when either cytogenetic and DNA studies confirmed the diagnosis, the incidence did not change. The immunophenotype of M3v cases was identical to that described for the hypergranular type, but an unexpected association of CD2 with M3v was shown. The onset was characterized by marked hyperleukocytosis (median WBC count, 87 x 10(9)/L) unlike classic APL. Disseminated intravascular coagulation (DIC) was always present and severe. Hyperleukocytosis and DIC were responsible for the high incidence of deaths for hemorrhagic events in the first days after onset (eight of 11 patients). CONCLUSIONS In our experience, for unknown reasons, M3v may occur in childhood more than generally was considered. The clinical course and prognosis seem worse in M3v than in typical APL cases.
A sparse Johnson: Lindenstrauss transform

Dimension reduction is a key algorithmic tool with many applications including nearest-neighbor search, compressed sensing and linear algebra in the streaming model. In this work we obtain a sparse version of the fundamental tool in dimension reduction -- the Johnson-Lindenstrauss transform. Using hashing and local densification, we construct a sparse projection matrix with just ~O(1/ε) non-zero entries per column. We also show a matching lower bound on the sparsity for a large class of projection matrices. Our bounds are somewhat surprising, given the known lower bounds of Ω(1/ε2) both on the number of rows of any projection matrix and on the sparsity of projection matrices generated by natural constructions. Using this, we achieve an ~O(1/ε) update time per non-zero element for a (1 ε)-approximate projection, thereby substantially outperforming the ~O(1/ε2) update time required by prior approaches. A variant of our method offers the same guarantees for sparse vectors, yet its ~O(d) worst case running time matches the best approach of Ailon and Liberty.
of Experimental Psychology: Human Perception and Performance Interaction Between Object-Based Attention and Pertinence Values Shapes the Attentional Priority Map of a Multielement Display

Between Object-Based Attention and Pertinence Values Previous studies have shown that the perceptual organization of the visual scene constrains the deploy-ment of attention. Here we investigated how the organization of multiple elements into larger configu- rations alters their attentional weight, depending on the “pertinence” or behavioral importance of the elements’ features. We assessed object-based effects on distinct aspects of the attentional priority map: top-down control, reflecting the tendency to encode targets rather than distracters, and the spatial distribution of attention weights across the visual scene, reflecting the tendency to report elements belonging to the same rather than different objects. In 2 experiments participants had to report the letters in briefly presented displays containing 8 letters and digits, in which pairs of characters could be connected with a line. Quantitative estimates of top-down control were obtained using Bundesen’s Theory of Visual Attention (1990). The spatial distribution of attention weights was assessed using the “paired response index” (PRI), indicating responses for within-object pairs of letters. In Experiment 1, grouping along the task-relevant dimension (targets with targets and distracters with distracters) in- creased top-down control and enhanced the PRI; in contrast, task-irrelevant grouping (targets with distracters) did not affect performance. In Experiment 2, we disentangled the effect of target-target and distracter-distracter grouping: Pairwise grouping of distracters enhanced top-down control whereas pairwise grouping of targets changed the PRI. We conclude that object-based perceptual representations interact with pertinence values (of the elements’ features and location) in the computation of attention weights, thereby creating a widespread pattern of attentional facilitation across the visual scene.
Instrumentos de medición de factores estresantes que afectan las personas en cuidado intensivo: revisión integrativa

Objetivo: Describir instrumentos de medicion de factores estresantes que afectan a las personas en cuidado intensivo. Metodologia: Revision bibliografica integrativa realizada sin delimitacion temporal a producciones cientificas escritas en espanol, ingles y portugues. Resultados: Se obtuvieron 18 articulos en los que se describe instrumentos de evaluacion de factores estresores en cuidado intensivo, sus propiedades psicometricas y el efecto de su aplicacion. Conclusion: La literatura reporta la existencia de tres instrumentos para la cuantificacion de factores estresantes en cuidados intensivos, con los mismos pacientes, sus familias y equipo de salud identifican las situaciones fisicas como las condiciones mas estresantes. Realizar este tipo de determinacion posibilita a enfermeria manipular el ambiente para producir un entorno mas terapeutico, mas humanizado, prevenir complicaciones y ajustar el plan de cuidados.
Automatic Prediction of Impressions in Time and across Varying Context: Personality, Attractiveness and Likeability

In this paper, we propose a novel multimodal framework for automatically predicting the impressions of extroversion, agreeableness, conscientiousness, neuroticism , openness, attractiveness and likeability continuously in time and across varying situational contexts. Differently from the existing works, we obtain visual-only and audio-only annotations continuously in time for the same set of subjects, for the first time in the literature, and compare them to their audio-visual annotations. We propose a time-continuous prediction approach that learns the temporal relationships rather than treating each time instant separately. Our experiments show that the best prediction results are obtained when regression models are learned from audio-visual annotations and visual cues, and from audio-visual annotations and visual cues combined with audio cues at the decision level. Continuously generated annotations have the potential to provide insight into better understanding which impressions can be formed and predicted more dynamically, varying with situational context, and which ones appear to be more static and stable over time.
Development of a Vaccine against Murine Cytomegalovirus (MCMV), Consisting of Plasmid DNA and Formalin-Inactivated MCMV, That Provides Long-Term, Complete Protection against Viral Replication

ABSTRACT We previously demonstrated that immunization of mice with plasmid DNAs (pDNAs) expressing the murine cytomegalovirus (MCMV) genes IE1-pp89 and M84 provided synergistic protection against sublethal viral challenge, while immunization with plasmids expressing putative virion proteins provided no or inconsistent protection. In this report, we sought to augment protection by increasing the breadth of the immune response. We identified another MCMV gene (m04 encoding gp34) that provided strong and consistent protection against viral replication in the spleen. We also found that immunization with a DNA pool containing 10 MCMV genes that individually were nonprotective elicited reproducible protection against low to intermediate doses of challenge virus. Moreover, inclusion of these plasmids into a mixture with gp34, pp89, and M84 DNAs provided even greater protection than did coimmunization with pp89 and M84. The highest level of protection was achieved by immunization of mice with the pool of 13 pDNAs, followed by formalin-inactivated MCMV (FI-MCMV). Immunization with FI-MCMV elicited neutralizing antibodies against salivary gland-derived MCMV, and of greatest importance, mice immunized with both the combined pDNA pool and FI-MCMV had undetectable levels of virus in the spleen and salivary glands after challenge. Intracellular cytokine staining of splenocytes from pDNA- and FI-MCMV-immunized mice showed that pDNA immunization elicited high levels of pp89- and M83-specific CD8+ T cells, whereas both pDNA and FI-MCMV immunizations generated strong CD8+-T-cell responses against virion-associated antigens. Taken together, these results show that immunization with pDNA and inactivated virus provides strong antibody and cell-mediated immunity against CMV infection.
The Tei index of myocardial performance: applications in cardiology.

of classical echocardiographic indexes for the estimation of systolic and diastolic left ventricular (LV) function. The ejection fraction (EF, an index of systolic function) and LV volumes are subject to large errors when the ellipsoid shape of the heart becomes spherical. Age, rhythm and conduction disturbances, and changes in loading all affect the Doppler signal of transmitral flow, which is the most commonly used method for studying diastolic function. Tei Chuwa devised and published in 1995 an index of myocardial performance (the Tei index) that evaluates the LV systolic and diastolic function in combination. The Tei index has proved to be a reliable method for the evaluation of LV systolic and diastolic performance, with clear advantages over older established indexes and prognostic value in many kinds of heart disease.
Long-term exercise training decreases interleukin-6 (IL-6) serum levels in subjects with impaired glucose tolerance: effect of the -174G/C variant in IL-6 gene.

OBJECTIVE Exercise training has been shown to have anti-inflammatory effects in patients with type 2 diabetes. Changes in interleukin-6 (IL-6) serum concentrations in response to training could contribute to these beneficial effects. However, there are heterogeneous data on whether circulating IL-6 is altered by exercise training. We therefore hypothesize that genetic factors modify the individual changes in IL-6 levels after long-term training. RESEARCH DESIGN AND METHODS The -174G/C variant in the IL-6 gene was genotyped in 60 subjects with impaired glucose tolerance. For a 12-month interventional study, patients were randomized into three groups: a control group (n=16) was compared with one group, which underwent a standardized training program (n=24) and another group, which was treated with 4 mg rosiglitazone once daily (n=20). At baseline, after 1, 6, and 12 months, we measured anthropometric parameters and serum concentration of IL-6 and, at baseline and after 12 months, we determined glucose tolerance and fitness level. RESULTS Only in subjects carrying the SNP -174C allele did long-term exercise training result in significantly reduced IL-6 serum concentrations. Multivariate linear regression analysis identified the IL-6 genotype as a significant predictor of changes in IL-6 serum concentrations independent of age, gender and improvement in body mass index, hemoglobin (Hb)A(1c), and fitness level in response to training. CONCLUSIONS Genetic variants in the IL-6 gene significantly modify changes in IL-6 serum concentrations in response to long-term exercise training programs. Our data suggest that genetic factors are important determinants for the individual response to anti-inflammatory effects of exercise training.
A Biobehavioral Perspective on Depressive Symptoms in Patients With Cerebral Astrocytoma

ABSTRACT More than 51,000 individuals are diagnosed with a primary brain tumor in the United States each year, and for those with the most common type of malignant tumor, an astrocytoma, almost 75% will die within 5 years of diagnosis. Although surgery, radiation, and chemotherapy have improved length of survival, mortality remains high, which underscores the need to understand how other factors affect the disease trajectory. Several recent studies have shown that depressive symptoms are independently associated with reduced quality of life and survival time after controlling for other variables in patients with an astrocytoma. Thus, depressive symptoms represent a significant risk factor for adverse outcomes in this patient population. A growing body of evidence indicates that depressive symptoms are linked to underlying biological phenomena, particularly inflammatory activation modulated through increased peripheral levels of proinflammatory cytokines. Recent research has shown that neoplastic astrocytes respond to elevated proinflammatory cytokine levels by secreting immune mediators within the central nervous system, including cytokines and glial fibrillary acidic protein that promote astrogliosis and angiogenesis and may increase tumor growth and metastasis. However, because these biological factors have not as yet been measured in conjunction with depressive symptoms in these patients, little is known about the interactions that potentially influence the treatment trajectory. To guide future research and to provide a deeper understanding of the factors that may influence depressive symptoms and length of survival in patients with an astrocytoma, a review of the literature was undertaken. Publications over the past 10 years were analyzed to examine the theoretical models and measures of depressive symptoms used in previous research. Although numerous studies have documented the relationship between depression and reduced length of survival, there were several methodological concerns identified, and there were no studies that included biological variables. Yet, research in the basic sciences provides compelling evidence of specific neuroendocrine-immune interactions orchestrated by astrocytes that can cause depressive symptoms and alter the tumor microenvironment so that standard treatments are not as effective. These findings support the need for clinically based research so that we can begin to understand the potentially modifiable biobehavioral mechanisms underlying depressive symptoms in patients with an astrocytoma. Grounded in the biobehavioral research paradigm of psychoneuroimmunology, a novel research program is presented that may provide a new level of understanding regarding the high prevalence of depressive symptoms in patients with an astrocytoma and lead to new treatment strategies, with possible implications for improved symptom management and quality of life in patients with brain tumors.
Effects of Calcium Spikes in the Layer 5 Pyramidal Neuron on Coincidence Detection and Activity Propagation

The role of dendritic spiking mechanisms in neural processing is so far poorly understood. To investigate the role of calcium spikes in the functional properties of the single neuron and recurrent networks, we investigated a three compartment neuron model of the layer 5 pyramidal neuron with calcium dynamics in the distal compartment. By performing single neuron simulations with noisy synaptic input and occasional large coincident input at either just the distal compartment or at both somatic and distal compartments, we show that the presence of calcium spikes confers a substantial advantage for coincidence detection in the former case and a lesser advantage in the latter. We further show that the experimentally observed critical frequency phenomenon, in which action potentials triggered by stimuli near the soma above a certain frequency trigger a calcium spike at distal dendrites, leading to further somatic depolarization, is not exhibited by a neuron receiving realistically noisy synaptic input, and so is unlikely to be a necessary component of coincidence detection. We next investigate the effect of calcium spikes in propagation of spiking activities in a feed-forward network (FFN) embedded in a balanced recurrent network. The excitatory neurons in the network are again connected to either just the distal, or both somatic and distal compartments. With purely distal connectivity, activity propagation is stable and distinguishable for a large range of recurrent synaptic strengths if the feed-forward connections are sufficiently strong, but propagation does not occur in the absence of calcium spikes. When connections are made to both the somatic and the distal compartments, activity propagation is achieved for neurons with active calcium dynamics at a much smaller number of neurons per pool, compared to a network of passive neurons, but quickly becomes unstable as the strength of recurrent synapses increases. Activity propagation at higher scaling factors can be stabilized by increasing network inhibition or introducing short term depression in the excitatory synapses, but the signal to noise ratio remains low. Our results demonstrate that the interaction of synchrony with dendritic spiking mechanisms can have profound consequences for the dynamics on the single neuron and network level.
Spatially and Intertemporally Efficient Waste Management: The Costs of Interstate Trade Restrictions

Abstract We examine the intertemporal allocation of the solid waste of cities within the United States to spatially distributed landfills and incinerators, taking into account that capacity at existing and potential landfills is scarce. Amendments have been proposed to restrict waste flows between states by means of quotas and surcharges. We assess the aggregate surplus loss (and its regional distribution) resulting from proposed policies. In addition, we find that limitations on the size of shipments to any one state can have the perverse effect of substantially increasing interstate waste shipments as states export smaller volumes to more destinations.
Dissolved trace metal speciation in estuarine and coastal waters: Comparison of WHAM/Model VII predictions with analytical results

The authors apply the chemical speciation model WHAM/Model VII to investigate the distribution of metal species of Fe(III) and the divalent cations of Ni, Cu, Zn, Cd, Hg, and Pb, in the water column of estuaries and coastal areas. The authors compare, for the same locations, measured and modeled free ion and organically bound metal concentrations. The modeled free ion calculations show varying levels of agreement with experimental measurements. Where only natural organic matter is considered as the organic ligand, for Ni, Cd, and Pb, agreement within 1 order of magnitude is found in 122 of 128 comparisons. For Fe and Zn comparisons 12 of 34 (Fe) and 10 of 18 (Zn) agree to within 1 order of magnitude, the remaining modeled values being over 1 order of magnitude higher than measurements. Copper measurements agree within 1 order of magnitude of modeled values in 314 of 533 (59%) cases and are more than 1 order of magnitude lower than modeled values in 202 cases. There is a general tendency for agreement between modeled and measured values to improve with increasing total metal concentrations. There are substantial variations among different analysis techniques but no systematic bias from the model is observed across techniques. It would be beneficial to cross‐validate the different analytical methods, in combination with further modeling. The authors also assessed the effect of including an anthropogenic organic ligand (ethylenediamine tetraacetic acid (EDTA)) in the modeling, given its known presence in some coastal environments. Except for Cd, all metals were sensitive to the presence of EDTA, even at a low concentration of 50 nM. Environ Toxicol Chem 2015;34:53–63. © 2014 SETAC. The copyright statement for this article was changed in September 2016, after its original publication.
Serum desialylated glycoproteins in patients with hepatobiliary dysfunction.

Abstract Levels of circulating desialylated glycoproteins were measured by means of a rat hepatocyte plasma membrane inhibition assay in 173 patients with hepatobiliary disease and in 18 normal controls. Control levels were 7.58 ± 3.5 S.D. expressed as nanogram equivalents of DTBG per 10μl of serum. Elevations greater than 2 S.D. from the control mean were found in 94% of the patients with alcoholic cirrhosis and in 85% of the patients with hepatic neoplasms. Elevations of serum desialylated glycoproteins also occurred in the serum of patients with hepatitis and cholestasis, but these elevations were more variable and appeared to correlate with the duration and severity of the disease at the time at which the serum sample was obtained. Elevations also occurred in patients with congestive heart failure and correlated with the duration of failure. In 73 of the patients results of conventional liver function tests as well as of the ABT's were available. There did not appear to be any simple correlation between abnormalities in the conventional tests and elevations of serum desialylated glycoproteins. Measurement of circulating desialylated glycoproteins has the potential of providing a clinically useful means of assessing hepatocellular destruction or abnormal hepatic glycoprotein synthesis, particularly in patients suspected of having cirrhosis or hepatic malignancy.
The Quarterly Journal of Experimental Psychology Action–effect Congruence during Observational Learning Leads to Faster Action Sequence Learning

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