Miracle-dz/UniFAR-FTUs huggingface dataset:
Overcoming catastrophic forgetting with hard attention to the task

Catastrophic forgetting occurs when a neural network loses the information learned in a previous task after training on subsequent tasks. This problem remains a hurdle for artificial intelligence systems with sequential learning capabilities. In this paper, we propose a task-based hard attention mechanism that preserves previous tasks' information without affecting the current task's learning. A hard attention mask is learned concurrently to every task, through stochastic gradient descent, and previous masks are exploited to condition such learning. We show that the proposed mechanism is effective for reducing catastrophic forgetting, cutting current rates by 45 to 80%. We also show that it is robust to different hyperparameter choices, and that it offers a number of monitoring capabilities. The approach features the possibility to control both the stability and compactness of the learned knowledge, which we believe makes it also attractive for online learning or network compression applications.
Impact of Age and Baseline NIHSS Scores on Clinical Outcomes in the Mechanical Thrombectomy Using Solitaire FR in Acute Ischemic Stroke Study

BACKGROUND AND PURPOSE: Age and stroke severity are inversely correlated with the odds of favorable outcome after ischemic stroke. A previously proposed score for Stroke Prognostication Using Age and NIHSS Stroke Scale (SPAN) indicated that SPAN-100-positive patients (ie, age + NIHSS score = 100 or more) do not benefit from IV-tPA. If this finding holds true for endovascular therapy, this score can impact patient selection for such interventions. This study investigated whether a score combining age and NIHSS score can improve patients' selection for endovascular stroke therapy. MATERIALS AND METHODS: The SPAN index was calculated for patients in the prospective Solitaire FR Thrombectomy for Acute Revascularization study: an international single-arm multicenter cohort for anterior circulation stroke treatment by using the Solitaire FR. The proportion with favorable outcome (90-day mRS score ≤2) was compared between SPAN-100-positive versus-negative patients. RESULTS: Of the 202 patients enrolled, 196 had baseline NIHSS scores. Fifteen (7.7%) patients were SPAN-100-positive. There was no difference in the rate of successful reperfusion (Thrombolysis In Cerebral Infarction 2b or 3) between SPAN-100-positive versus -negative groups (93.3% versus 82.8%, respectively; P = .3). Stroke SPAN-100-positive patients had a significantly lower proportion of favorable clinical outcomes (26.7% versus 60.8% in SPAN-100-negative, P = .01). In a multivariable analysis, SPAN-100-positive status was associated with lower odds of favorable outcome (OR, 0.3; 95% CI, 0.1–0.9; P = .04). A higher baseline Alberta Stroke Program Early CT Score and a short onset to revascularization time also predicted favorable outcome in the multivariable analysis. CONCLUSIONS: A significantly lower proportion of patients with a positive SPAN-100 achieved favorable outcome in this cohort. SPAN-100 was an independent predictor of favorable outcome after adjusting for time to treatment and the extent of preintervention tissue damage according to the Alberta Stroke Program Early CT Score.
Evaluation of a High-Throughput Fluorescence Assay Method for hERG Potassium Channel Inhibition

The number of projects in drug development that fail in late phases because of cardiac side effects such as QT prolongation can impede drug discovery and development of projects. The molecular target responsible for QT prolongation by a wide range of pharmaceutical agents is the myocardial hERG potassium channel. It is therefore desirable to screen for compound interactions with the hERG channel at an early stage of drug development. Here, the authors report a cell-based fluorescence assay using membrane potential-sensitive fluorescent dyes and stably transfected hERG channels from CHO cells. The assay allows semiautomated screening of compounds for hERG activity on 384-well plates and is sufficiently rapid for testing a large number of compounds. The assay is robust as indicated by a Z′ factor larger than 0.6. The throughput is in the range of 10,000 data points per day, which is significantly higher than any other method presently available for hERG. The data obtained with the fluorescence assay were in qualitative agreement with those from patch-clamp electrophysiological analysis. There were no false-positive hits, and the rate of false-negative compounds is currently 12% but might be further reduced by testing compounds at higher concentration. Quantitative differences between fluorescence and electrophysiological methods may be due to the use- or voltage-dependentactivity of the antagonists.
Globally Optimal DLS Method for PnP Problem with Cayley parameterization

The perspective-n-point (PnP) problem, which estimates 3D rotation and translation of a calibrated camera from n pairs of known 3D points and corresponding 2D image points, is a classical problem but still fundamental in the computer vision community. It is well studied that the PnP problem can be solved by at least three points [1]. If n ≥ 4, the PnP problem becomes a nonlinear problem where the number of the solutions depend on n and the shape of the scene. This paper proposes an efficient, scalable, and globally optimal DLS method parameterized by Cayley representation, which has been regarded as a unsuitable parametrization due to its singularity. First we derive a new optimality condition without Lagrange multipliers. Letting pi = [xi,yi,zi] be an i-th 3D point and mi = [ui,vi,1] be the corresponding calibrated image point in homogeneous coordinates, the PnP problem can be formulated as a nonlinear optimization
Axillary Dissection and Nodal Irradiation Can Be Avoided for Most Node-positive Z0011-eligible Breast Cancers: A Prospective Validation Study of 793 Patients

Objective: To determine rates of axillary dissection (ALND) and nodal recurrence in patients eligible for ACOSOG Z0011. Background: Z0011 demonstrated that patients with cT1-2N0 breast cancers and 1 to 2 involved sentinel lymph nodes (SLNs) having breast-conserving therapy had no difference in locoregional recurrence or survival after SLN biopsy alone or ALND. The generalizability of the results and importance of nodal radiotherapy (RT) is unclear. Methods: Patients eligible for Z0011 had SLN biopsy alone. Prospectively defined indications for ALND were metastases in ≥3 SLNs or gross extracapsular extension. Axillary imaging was not routine. SLN and ALND groups and radiation fields were compared with chi-square and t tests. Cumulative incidence of recurrences was estimated with competing risk analysis. Results: From August 2010 to December 2016, 793 patients met Z0011 eligibility criteria and had SLN metastases. Among them, 130 (16%) had ALND; ALND did not vary based on age, estrogen receptor, progesterone receptor, or HER2 status. Five-year event-free survival after SLN alone was 93% with no isolated axillary recurrences. Cumulative 5-year rates of breast + nodal and nodal + distant recurrence were each 0.7%. In 484 SLN-only patients with known RT fields (103 prone, 280 supine tangent, 101 breast + nodes) and follow-up ≥12 months, the 5-year cumulative nodal recurrence rate was 1% and did not differ significantly by RT fields. Conclusions: We confirm that even without preoperative axillary imaging or routine use of nodal RT, ALND can be avoided in a large majority of Z0011-eligible patients with excellent regional control. This approach has the potential to spare substantial numbers of women the morbidity of ALND.
Can We Go Beyond Burned Area in the Assessment of Global Remote Sensing Products with Fire Patch Metrics?

Global burned area (BA) datasets from satellite Earth observations provide information for carbon emission and for Dynamic Global Vegetation Model (DGVM) benchmarking. Fire patch identification from pixel-level information recently emerged as an additional way of providing informative features about fire regimes through the analysis of patch size distribution. We evaluated the ability of global BA products to accurately represent morphological features of fire patches, in the fire-prone Brazilian savannas. We used the pixel-level burned area from LANDSAT images, as well as two global products: MODIS MCD45A1 and the European Space Agency (ESA) fire Climate Change Initiative (FIRE_CCI) product for the 2002–2009 time period. Individual fire patches were compared by linear regressions to test the consistency of global products as a source of burned patch shape information. Despite commission and omission errors respectively reaching 0.74 and 0.81 for ESA FIRE_CCI and 0.64 and 0.62 for MCD45A1 when compared to LANDSAT due to missing small fires, correlations between patch areas showed R2 > 0.6 for all comparisons, with a slope of 0.99 between ESA FIRE_CCI and MCD45A1 but a lower slope (0.6–0.8) when compared to the LANDSAT data. Shape complexity between global products was less correlated (R2 = 0.5) with lower values (R2 = 0.2) between global products and LANDSAT data, due to their coarser resolution. For the morphological features of the ellipse fitted over fire patches, R2 reached 0.6 for the ellipse’s eccentricity and varied from 0.4 to 0.8 for its azimuthal directional angle. We conclude that global BA products underestimate total BA as they miss small fires, but they also underestimate burned patch areas. Patch complexity is the least correlated variable, but ellipse features appear to provide information to be further used for quality product assessment, global pyrogeography or DGVM benchmarking.
The Prince and the Pauper: Search and Brokerage in the Initiation of Status-Heterophilous Ties

We combine structural hole theory with performance feedback theory to identify determinants of partner selection in networks. Specifically, we examine how a brokerage position coupled with aspiration--performance gaps affects an organization's propensity to initiate ties to partners of different status. We find that organizations in brokerage positions are more likely than nonbrokers to initiate such ties systematically. However, when the performance of an organization in a brokerage position deviates from its aspirations, the organization changes its partner selection strategy and starts initiating ties to partners of similar status. Our results also suggest that organizations in brokerage positions set social and historical aspiration levels differently from nonbrokers, levels that in turn affect decisions about partner selection.
Location and Time Aware Social Collaborative Retrieval for New Successive Point-of-Interest Recommendation

In location-based social networks (LBSNs), new successive point-of-interest (POI) recommendation is a newly formulated task which tries to regard the POI a user currently visits as his POI-related query and recommend new POIs the user has not visited before. While carefully designed methods are proposed to solve this problem, they ignore the essence of the task which involves retrieval and recommendation problem simultaneously and fail to employ the social relations or temporal information adequately to improve the results. In order to solve this problem, we propose a new model called location and time aware social collaborative retrieval model (LTSCR), which has two distinct advantages: (1) it models the location, time, and social information simultaneously for the successive POI recommendation task; (2) it efficiently utilizes the merits of the collaborative retrieval model which leverages weighted approximately ranked pairwise (WARP) loss for achieving better top-n ranking results, just as the new successive POI recommendation task needs. We conducted some comprehensive experiments on publicly available datasets and demonstrate the power of the proposed method, with 46.6% growth in Precision@5 and 47.3% improvement in Recall@5 over the best previous method.
Evaluating the Role of Epigenetic Histone Modifications in the Metabolic Memory of Type 1 Diabetes

We assessed whether epigenetic histone posttranslational modifications are associated with the prolonged beneficial effects (metabolic memory) of intensive versus conventional therapy during the Diabetes Control and Complications Trial (DCCT) on the progression of microvascular outcomes in the long-term Epidemiology of Diabetes Interventions and Complications (EDIC) study. We performed chromatin immunoprecipitation linked to promoter tiling arrays to profile H3 lysine-9 acetylation (H3K9Ac), H3 lysine-4 trimethylation (H3K4Me3), and H3K9Me2 in blood monocytes and lymphocytes obtained from 30 DCCT conventional treatment group subjects (case subjects: mean DCCT HbA1c level >9.1% [76 mmol/mol] and progression of retinopathy or nephropathy by EDIC year 10 of follow-up) versus 30 DCCT intensive treatment subjects (control subjects: mean DCCT HbA1c level <7.3% [56 mmol/mol] and without progression of retinopathy or nephropathy). Monocytes from case subjects had statistically greater numbers of promoter regions with enrichment in H3K9Ac (active chromatin mark) compared with control subjects (P = 0.0096). Among the patients in the two groups combined, monocyte H3K9Ac was significantly associated with the mean HbA1c level during the DCCT and EDIC (each P < 2.2E-16). Of note, the top 38 case hyperacetylated promoters (P < 0.05) included >15 genes related to the nuclear factor-κB inflammatory pathway and were enriched in genes related to diabetes complications. These results suggest an association between HbA1c level and H3K9Ac, and a possible epigenetic explanation for metabolic memory in humans.
Comparison of SUZI and ICSI for severe male factor.

We compare the results of subzonal insemination (SUZI) and intracytoplasmic sperm injection (ICSI) carried out between February 1993 and end of August 1994. A total of 232 couples underwent 302 cycles of micro-assisted fertilization (79 patients had SUZI for a total of 93 cycles, 153 patients ICSI for a total of 209 cycles). The indications for treatment were obstructive azoospermia in 35 cycles, ejaculatory failure with severely low sperm count in 7 cycles, and failure of fertilization in a previous IVF cycle or less than 10% of oocytes fertilized in 87 cycles. In 173 cycles the indication for treatment was a poor semen parameter. Patients undergoing ICSI had significantly higher fertilization rates [43 (728/1692) versus 22.3% (151/ 676), chi 2 = 86.308, P < 0.0001], better chances of embryo transfer [95 (199/209) versus 73% (68/93), chi 2 = 30.671, P < 0.001], and greater numbers of embryos transferred (2.4 +/- 0.9 versus 1.6 +/- 1.2 F = 42, P < 0.0001) than patients who had SUZI. Eighteen patients became pregnant following the SUZI procedure, a pregnancy rate of 19% per egg collection, compared with 28% for those who underwent the ICSI procedure, where 58 out of 209 became pregnant. The pregnancy rate was similar in those who underwent embryo transfer, whether they had ICSI or SUZI (29.2 and 28.6% respectively). Overall, the pregnancy rate doubled with each number of embryos transferred, so it was 8.9% when one embryo was transferred, which increased to 18.3% when two embryos were transferred, and this rose to 37.7% when three embryos were transferred. There was no significant difference in the pregnancy wastage rate between SUZI and ICSI. None of the offspring from either SUZI or ICSI showed any evidence of fetal abnormalities. Pregnancy rate was negatively correlated, with sperm progression being 36% (36/100) if progression was < 2 and 19.8% (40/202) if it was > or = 2 (chi 2 = 8.99, P < .002). ICSI therefore provides a higher number of embryos available for transfer and should be the primary treatment for severe male factor infertility.
Effect of surfacing patterns on abundance estimates of long-diving animals

Population sizes of long-diving marine mammals can be estimated with minimal bias using line transect sampling techniques in conjunction with data on surfacing/diving, even though the detection probability on the trackline is considerably less than 1. Using a simulation, it was investigated whether population sizes can be accurately estimated when only the mean cue production rate, without information on surfacing/diving patterns, is available. In addition, a new model that incorporates information on surfacing/diving patterns into the estimation procedure was developed. The simulation showed that the new model can provide less biased abundance estimates, whereas neglecting surfacing/diving patterns can result in serious underestimates of abundance, in particular for longdiving animals.
Lysine Represses Transcription of the Escherichia coli dapB Gene by Preventing Its Activation by the ArgP Activator

ABSTRACT The Escherichia coli dapB gene encodes one of the enzymes of the biosynthetic pathway leading to lysine and its immediate precursor, diaminopimelate. Expression of dapB is repressed by lysine, but no trans-acting regulator has been identified so far. Our analysis of the dapB regulatory region shows that sequences located in the −81/−118 interval upstream of the transcription start site are essential for full expression of dapB, as well as for lysine repression. Screening a genomic library for a gene that could alleviate lysine repression when present in multicopy led to the recovery of argP, a gene encoding an activating protein of the LysR-type family, known to use lysine as an effector. An argP null mutation strongly decreases dapB transcription that becomes insensitive to lysine. Purified His6-tagged ArgP protein binds with an apparent K d of 35 nM to the dapB promoter in a gel retardation assay, provided that sequences up to −103 are present. In the presence of l-lysine and l-arginine, the binding of ArgP to dapB is partly relieved. These results fit with a model in which ArgP contributes to enhanced transcription of dapB when lysine becomes limiting.
The Open University ’ s repository of research publications and other research outputs The JCMT Gould Belt Survey : A First Look at IC

We present 450 and 850 μm submillimeter continuum observations of the IC 5146 star-forming region taken as part of the James Clerk Maxwell Telescope Gould Belt Survey. We investigate the location of bright submillimeter (clumped) emission with the larger-scale molecular cloud through comparison with extinction maps, and find that these denser structures correlate with higher cloud column density. Ninety-six individual submillimeter clumps are identified using FellWalker,and their physical properties are examined. These clumps are found to be relatively massive, ranging from 0.5  M to 116  M with a mean mass of 8  M and a median mass of 3.7  M . A stability analysis for the clumps suggests that the majority are (thermally) Jeans stable, with < M M 1 J . We further compare the locations of known protostars with the observed submillimeter emission, finding that younger protostars, i.e., Class 0 and I sources, are strongly correlated with submillimeter peaks and that the clumps with protostars are among the most Jeans unstable. Finally, we contrast the evolutionary conditions in the two major star-forming regions within IC 5146: the young cluster associated with the Cocoon Nebula and the more distributed star formation associated with the Northern Streamer filaments. The Cocoon Nebula appears to have converted a higher fraction of its mass into dense clumps and protostars, the clumps are more likely to be Jeans unstable, and a larger fraction of these remaining clumps contain embedded protostars. The Northern Streamer, however, has a larger number of clumps in total and a larger fraction of the known protostars are still embedded within these clumps.
An Integrated Approach to â€œSustainable Community-Based Tourismâ€

Two rich knowledge domains have been evolving along parallel pathways in tourism studies: sustainable tourism (ST) and community-based tourism (CBT). Within both lie diverse definitions, principles, criteria, critical success factors and benefits sought or outcomes desired, advocated by different stakeholders ranging from quasi-governmental and non-profit organizations to public-private sector and academic interests. This poses significant challenges to those interested in theory building, research and practice in the sustainable development and management of tourism. The paper builds on a previous article published in Sustainability by presenting an integrated framework based on a comprehensive, in-depth review and analysis of the tourism-related literature. The study reveals not just common ground and differences that might be anticipated, but also important sustainability dimensions that are lagging or require much greater attention, such as equity, justice, ethical and governance issues. A preliminary framework of â€œsustainable community-based tourismâ€ (SCBT) is forwarded that attempts to bridge the disparate literature on ST and CBT. Critical directions forward are offered to progress research and sustainability-oriented practices towards more effective development and management of tourism in the 21st century.
Cytomegalic Interneurons: A New Abnormal Cell Type in Severe Pediatric Cortical Dysplasia

Abstract A defining histopathologic feature of Taylor-type cortical dysplasia (CD) is the presence of cytomegalic neurons and balloon cells. Most cytomegalic neurons appear to be pyramidal-shaped and glutamatergic. The present study demonstrates the presence of cytomegalic GABAergic interneurons in a subset of pediatric patients with severe CD. Cortical tissue samples from children with mild, severe, and non-CD pathologies were examined using morphologic and electrophysiologic techniques. By using in vitro slices, cytomegalic cells with characteristics consistent with interneurons were found in 6 of 10 patients with severe CD. Biocytin labeling demonstrated that cytomegalic interneurons had more dendrites than normal-appearing interneurons. Whole-cell patch clamp recordings showed that cytomegalic interneurons had increased membrane capacitance and time constant compared with normal-appearing interneurons. They also displayed signs of cellular hyperexcitability, evidenced by increased firing rates, decreased action potential inactivation, and the occurrence of spontaneous membrane depolarizations. Single-cell reverse transcription-polymerase chain reaction and immunohistochemistry for GABAergic markers provided further evidence that these cells were probably cytomegalic interneurons. The pathophysiologic significance of GABAergic cytomegalic interneurons in severe CD tissue is unknown, but they could inhibit glutamatergic cytomegalic pyramidal neurons, or contribute to the synchronization of neuronal networks and the propagation of ictal activity in a subset of pediatric patients with severe CD.