Miracle-dz/UniFAR-FTUs huggingface dataset:
IJPDLM 32 , 10 852 referred to as e-commerce : the trade of goods

E-commerce is such a new phenomenon that little research has addressed the effects it has on relationships in supply chains. A qualitative study was conducted with eight e-commerce companies in order to construct theoretical relationships with which to develop a grounded theory of the impact of e-commerce on managing supply chain relationships. The e-commerce environment was perceived as highly uncertain, stemming from increased information visibility and dynamic market structures. A stronger emphasis on relationship management as part of business strategy enables managers to manage uncertainty better. Interestingly, increased information does not decrease the perception of uncertainty, but creates more uncertainty. As logistics is the function often involved with both information and relationship management within the supply chain, it may prove to be invaluable in helping firms succeed in this dynamic environment. Our research also found support for the application of transaction cost analysis and the resource dependence theory in explaining interorganizational relationship formation in e-commerce. Introduction A supply chain can be defined as three or more organizations directly linked by one or more of the flows of products, services, finances, and information from a source to a customer (Mentzer et al., 2001). Management of the supply chain is essentially management of the relationships and activities among the member organizations. These relationships range from single transactions to complex interdependent relationships. As the business environment becomes more complex, organizations recognize that many benefits can be obtained from closer, long-term relationships (Ganesan, 1994). Day (2000) ventures to say that committed relationships are among the most durable of advantages because of their inherent barriers to competition. The goal of supply chain management is for member organizations to work together in close, long-term relationships to increase the competitive advantage of the supply chain as a whole (Mentzer et al., 2001). The phenomenon referred to as `̀ the next business revolution’’ – the nexus of computers, networks, people, and business goals for purposes of selling goods, services, and information – is an innovative way to cut costs, grow markets and profitability, and improve shareholder return relative to traditional business methods (Palmisano, 1998). This combination is the business phenomenon The research register for this journal is available at http://www.emeraldinsight. com/researchregisters The current issue and full text archive of this journal is available at http://www.emeraldinsight. com/0960-0035.htm The authors wish to thank FedEx, Lucent Technologies and Cenedian for co-sponsoring the research. They also wish to thank the participating companies and the editor and reviewers for their insightful comments.
Empirical Studies in the Measurement of Socio-economic Inequality in Health

textabstractDespite a long-term and intensive interest in the measurement of socio-economic health inequalities, the collection of accurate and comparable information still is a daunting task. This thesis presents several challenges that researchers face. It also provides new empirical evidence on socio-economic inequalities in different areas. The results confirm previous findings of a better health experience for the rich and highly educated. Moreover, the results show that with the right techniques and data many of the measurement problems that researchers face can be accounted for.
Production , Manufacturing and Logistics A dynamic rationing policy for continuous-review inventory systems

0377-2217/$ see front matter 2009 Elsevier B.V. A doi:10.1016/j.ejor. 2009.05. 043 * Corresponding author. E-mail address: mmurat@bilkent.edu. tr (M.M. Fad Stock rationing is an inventory policy that allows differential treatment of customer classes without using separate inventories. In this paper, we propose a dynamic rationing policy for continuous-review inventory systems, which utilizes the information on the status of the outstanding replenishment orders. For both backordering and lost sales environments, we conduct simulation studies to compare the performance of the dynamic policy with the static critical level and the common stock policies and quantify the gain obtained. We propose two new bounds on the optimum dynamic rationing policy that enables us to tell how much of the potential gain the proposed dynamic policy realizes. We discuss the conditions under which stock rationing – both dynamic and static – is beneficial and assess the value of the dynamic policy. 2009 Elsevier B.V. All rights reserved.
Ovarian carcinoma CDK12 mutations misregulate expression of DNA repair genes via deficient formation and function of the Cdk12/CycK complex

The Cdk12/CycK complex promotes expression of a subset of RNA polymerase II genes, including those of the DNA damage response. CDK12 is among only nine genes with recurrent somatic mutations in high-grade serous ovarian carcinoma. However, the influence of these mutations on the Cdk12/CycK complex and their link to cancerogenesis remain ill-defined. Here, we show that most mutations prevent formation of the Cdk12/CycK complex, rendering the kinase inactive. By examining the mutations within the Cdk12/CycK structure, we find that they likely provoke structural rearrangements detrimental to Cdk12 activation. Our mRNA expression analysis of the patient samples containing the CDK12 mutations reveals coordinated downregulation of genes critical to the homologous recombination DNA repair pathway. Moreover, we establish that the Cdk12/CycK complex occupies these genes and promotes phosphorylation of RNA polymerase II at Ser2. Accordingly, we demonstrate that the mutant Cdk12 proteins fail to stimulate the faithful DNA double strand break repair via homologous recombination. Together, we provide the molecular basis of how mutated CDK12 ceases to function in ovarian carcinoma. We propose that CDK12 is a tumor suppressor of which the loss-of-function mutations may elicit defects in multiple DNA repair pathways, leading to genomic instability underlying the genesis of the cancer.
Double mutant P53 (N340Q/L344R) promotes hepatocarcinogenesis through upregulation of Pim1 mediated by PKM2 and LncRNA CUDR

P53 is frequently mutated in human tumors as a novel gain-of-function to promote tumor development. Although dimeric (M340Q/L344R) influences on tetramerisation on site-specific post-translational modifications of p53, it is not clear how dimeric (M340Q/L344R) plays a role during hepatocarcinogenesis. Herein, we reveal that P53 (N340Q/L344R) promotes hepatocarcinogenesis through upregulation of PKM2. Mechanistically, P53 (N340Q/L344R) forms complex with CUDR and the complex binds to the promoter regions of PKM2 which enhances the expression, phosphorylation of PKM2 and its polymer formation. Thereby, the polymer PKM2 (tetramer) binds to the eleventh threonine on histone H3 that increases the phosphorylation of the eleventh threonine on histone H3 (pH3T11). Furthermore, pH3T11 blocks HDAC3 binding to H3K9Ac that prevents H3K9Ac from deacetylation and stabilizes the H3K9Ac modification. On the other hand, it also decreased tri-methylation of histone H3 on the ninth lysine (H3K9me3) and increases one methylation of histone H3 on the ninth lysine (H3K9me1). Moreover, the combination of H3K9me1 and HP1 α forms more H3K9me3-HP1α complex which binds to the promoter region of Pim1, enhancing the expression of Pim1 that enhances the expression of TERT, oncogenic lncRNA HOTAIR and reduces the TERRA expression. Ultimately, P53 (N340Q/L344R) accerlerates the growth of liver cancer cells Hep3B by activating telomerase and prolonging telomere through the cascade of P53 (N340Q/L344R)-CUDR-PKM2-pH3T11- (H3K9me1-HP1α)-Pim1- (TERT-HOTAIR-TERRA). Understanding the novel functions of P53 (N340Q/L344R) will help in the development of new liver cancer therapeutic approaches that may be useful in a broad range of cancer types.
A Comparison of Spectral Angle Mapper and Artificial Neural Network Classifiers Combined with Landsat TM Imagery Analysis for Obtaining Burnt Area Mapping

Satellite remote sensing, with its unique synoptic coverage capabilities, can provide accurate and immediately valuable information on fire analysis and post-fire assessment, including estimation of burnt areas. In this study the potential for burnt area mapping of the combined use of Artificial Neural Network (ANN) and Spectral Angle Mapper (SAM) classifiers with Landsat TM satellite imagery was evaluated in a Mediterranean setting. As a case study one of the most catastrophic forest fires, which occurred near the capital of Greece during the summer of 2007, was used. The accuracy of the two algorithms in delineating the burnt area from the Landsat TM imagery, acquired shortly after the fire suppression, was determined by the classification accuracy results of the produced thematic maps. In addition, the derived burnt area estimates from the two classifiers were compared with independent estimates available for the study region, obtained from the analysis of higher spatial resolution satellite data. In terms of the overall classification accuracy, ANN outperformed (overall accuracy 90.29%, Kappa coefficient 0.878) the SAM classifier (overall accuracy 83.82%, Kappa coefficient 0.795). Total burnt area estimates from the two classifiers were found also to be in close agreement with the other available estimates for the study region, with a mean absolute percentage difference of ∼1% for ANN and ∼6.5% for SAM. The study demonstrates the potential of the examined here algorithms in detecting burnt areas in a typical Mediterranean setting.
Spurious transcription factor binding: Non-functional or genetically redundant?

Transcription factor binding sites (TFBSs) on the DNA are generally accepted as the key nodes of gene control. However, the multitudes of TFBSs identified in genome‐wide studies, some of them seemingly unconstrained in evolution, have prompted the view that in many cases TF binding may serve no biological function. Yet, insights from transcriptional biochemistry, population genetics and functional genomics suggest that rather than segregating into ‘functional’ or ‘non‐functional’, TFBS inputs to their target genes may be generally cumulative, with varying degrees of potency and redundancy. As TFBS redundancy can be diminished by mutations and environmental stress, some of the apparently ‘spurious’ sites may turn out to be important for maintaining adequate transcriptional regulation under these conditions. This has significant implications for interpreting the phenotypic effects of TFBS mutations, particularly in the context of genome‐wide association studies for complex traits.
LIGAND-INDUCED MOVEMENT OF LYMPHOCYTE MEMBRANE MACROMOLECULES

Capping of surface Ig by anti-Ig antibodies involves a membrane perturbation requiring an energy-dependent step. Lymphocytes treated with anti-Ig are stimulated to move. Previously, we had shown that movement was not essential for capping, although it influenced the localization of the cap. We have investigated the role of cell movement and of microtubular proteins in this phenomenon. Treatment of B lymphocytes with colchicine does not affect capping of Ig nor does it affect the increase in translational movement produced by anti-Ig antibodies. Treatment of lymphocytes with cytochalasin B stops translational movement and may affect capping to some degree under appropriate circumstances. Lymphocytes treated with both drugs are impaired in capping. We surmise that there may be two cytoplasmic events regulating directly or indirectly capping: one associated with the process of translational movement, the other associated with the activity of microtubules. Lymphocytes treated with concanavalin A do not cap Ig. Colchicine reverses this inhibition. Certain experimental procedures antagonize the colchicine effect, the most striking of which is the use of cytochalasin B. Colchicine appears to increase movement of the Con A-treated lymphocyte, and this increased movement appears responsible for the accumulation of complexes to the posterior part of the cell. Con A inhibits patching of Ig by anti-Ig, and this is not reversed by colchicine.
Dendritic Cells Require Multidrug Resistance Protein 1 (ABCC1) Transporter Activity for Differentiation1

Dendritic cells (DC) express the ATP-binding cassette (ABC) transporters P-glycoprotein (ABCB1) and multidrug resistance protein 1 (MRP1; ABCC1). Functionally, both these transporters have been described to be required for efficient DC and T cell migration. In this study, we report that MRP1 activity is also crucial for differentiation of DC. Inhibition of MRP1, but not P-glycoprotein, transporter activity with specific antagonists during in vitro DC differentiation interfered with early DC development. Impaired interstitial and Langerhans DC differentiation was characterized by 1) morphological changes, reflected by dropped side scatter levels in flow cytometric analysis and 2) phenotypic changes illustrated by maintained expression of the monocytic marker CD14, lower expression levels of CD40, CD86, HLA-DR, and a significant decrease in the amount of cells expressing CD1a, CD1c, and Langerin. Defective DC differentiation also resulted in their reduced ability to stimulate allogeneic T cells. We identified the endogenous CD1 ligands sulfatide and monosialoganglioside GM1 as MRP1 substrates, but exogenous addition of these substrates could not restore the defects caused by blocking MRP1 activity during DC differentiation. Although leukotriene C4 was reported to restore migration of murine Mrp1-deficient DC, the effects of MRP1 inhibition on DC differentiation appeared to be independent of the leukotriene pathway. Though MRP1 transporter activity is important for DC differentiation, the relevant MRP1 substrate, which is required for DC differentiation, remains to be identified. Altogether, MRP1 seems to fulfill an important physiological role in DC development and DC functions.
Has the Financial Crisis Permanently Changed the Practice of Monetary Policy? Has it Changed the Theory of Monetary Policy?

I argue in this paper that one of the two forms of hitherto unconventional monetary policy that many central banks have implemented in response to the 2007 financial crisis - large-scale asset purchases, or to put the matter more generically, use of the central bank's balance sheet as a distinct tool of monetary policy - is likely to become part of the standard toolkit of monetary policymaking in normal times as well. As intended, these purchases have lowered long-term interest rates relative to short-term rates, and lowered interest rates on more-risky compared to less-risky obligations. Moreover, their introduction fills a conceptual vacuum that has long stood at the heart of monetary policy analysis and implementation. By contrast, forward guidance on the future trajectory of monetary policy has been less successful. Public statements by central banks about their actions and intentions will no doubt continue, but transparency for the sake of transparency is not the same as the deliberate attempt to shape market expectations for purposes of achieving specific monetary policy objectives. Finally, there is a conceptual component to all this as well. In contrast to the last century or more of monetary theory, which has focused on central banks' liabilities, the basis for the effectiveness of central bank asset purchases turns on the role of the asset side of the central bank's balance sheet. The implications for monetary theory are profound.
An Adaptive Genetic Algorithm Based on Population Diversity Strategy

Genetic Algorithms are adaptive methods which may be used to solve search and optimization problems. Three basic operations in Genetic Algorithms are selection, crossover and mutation, an important problem using Genetic Algorithms is the premature convergence in local optimum. This paper presents an adaptive genetic algorithm which adjusts probability of mutation dynamicly based on average square deviation of population fitness value that shows the population diversity to solve premature problem. Compared Analysis shows the proposed adaptive Genetic Algorithm is efficient to avoid premature.
Does Social Democracy Matter? Corporate Governance Reforms in Switzerland and Sweden (1980-2005)

This paper tests the accuracy of Roe's (2003) claim that 'social democracies' tend to have insider-orientated corporate governance systems, for two extreme cases concerning Roe's independent variable: Switzerland and Sweden. Starting from a position in which both were clearly insider-orientated systems, there was a significant weakening of insider control in Switzerland during the 1990s, but no comparable change in Sweden up until the early 2000s. These developments occurred against the background of contrasting political contexts in the two countries: in Switzerland, change took place in a context of stable dominance over the political arena by centre-right parties; in Sweden, no change took place despite the fact that centre-right parties managed several times to break the traditional social-democratic dominance over government. Thus it would seem that political power relations as such do not explain the observed trajectories of these two corporate governance systems. Instead, the different trajectories are explained by the different preferences of central political and economic actors. The Swiss labour movement, which was traditionally under the dominance of a strong employer side, had important incentives to favour increasing external shareholder control over firms. Conversely, the Swedish labour movement, which had played a considerable part in the shaping of the Swedish corporate governance system, had no such incentives. Also, as Swiss banks started to reorientate their strategies towards financial market-related activities, they became a very important pro-shareholder reform force in Switzerland. Swedish banks, which were part of business groups in which financial interests did not necessarily prevail over industrial interests, did not play any comparable role.
A 'GOOD EMPLOYER' PERCEPTIONS AND PRACTICE IN SMALL ENTERPRISES.

The research explored the concept of a ‘good employer’ pertaining to employment relations and occupational health and safety (OHS) in small enterprises (SE’s). How perceptions, attitudes and beliefs of a ‘good employer’ were implemented in practice, were surveyed in a sample of SE’s using a framework developed from the International Labour Organisation (ILO) socially Decent Work Index (DWI). The study retained the DWI’s key dimensions: employment security, voice security, income security, skill reproduction security, and work security. However, measures of the key dimensions were broadened to capture the predominantly individualistic nature of employment relations in SE’s. The employers’ perceptions generally corresponded with the two dimensions of the ‘good employer’ prioritized by the ILO: employee voice and income security. In practice, there were instances of employees having input beyond operational matters. Nevertheless employers unilaterally determined pay and other terms and conditions of work. As for work security, the level of formal and informal policies and practices varied but employers who operated in higher OHS risk trade industries generally implemented comprehensive formal OHS management systems. It is argued that all it takes to be a ‘good employer’ is compliance with statutory employment minima. The employers in this study generally fulfilled this basic standard with some employers demonstrating higher levels of the characteristics that fitted with the dimensions associated with some large enterprises and the concept of a ‘good employer’ developed in the public sector. To accommodate space limitations, only brief summaries of the employer’ perceptions, attitudes and beliefs of a ‘good employer’ and Work Security are provided. This paper focuses on the results concerning voice and income security.
Mapping the cold molecular gas in a cooling flow cluster: Abell 1795

Cold molecular gas is found in several clusters of galaxies (Edge 2001; Salome & Combes 2003): single dish telescope observations in CO(1-0) and CO(2-1) emission lines have revealed the existence of large amounts of cold gas (up to ∼10 11 M ○. ) in the central region of cooling flow clusters. We present here interferometric observations performed with the IRAM Plateau de Bure interferometer in Abell 1795. Comparison with IRAM 30 m data shows the cold gas detected is extended suggesting a cooling flow origin. The CO features identified are very similar to the structures observed in H α and with the star forming regions observed through UV continuum excess. A large fraction of the cold gas is not centered on the central cD, but located near brightest X-ray emitting regions along the North-West orientated radio lobe. The cold gas kinematics is consistent with the optical nebulosity behaviour in the very central region. It is not in rotation around the central cD: a velocity gradient shows the cold gas might be cooled gas from the intra-cluster medium being accreted by the central galaxy. The optical filaments, aligned with the cD orbit, are intimately related to the radio jets and lobes. The material fueling the star formation certainly comes from the deposited gas, cooling more efficiently along the edge of the radio lobes. Even if some heating mechanisms are present, these millimetric observations show that an effective cooling to very low temperatures indeed occurs and is probably accelerated by the presence of the radio source.
Stromal cell-derived factor-1 as a chemoattractant for follicular center lymphoma B cells.

BACKGROUND Follicular center lymphoma displays widespread lymph node involvement at diagnosis. The chemoattractants that control the locomotion of follicular center lymphoma B cells have not been established. Stromal cell-derived factor-1 (SDF-1) is a CXC-class chemokine that enhances the migration of normal human B cells and is expressed in peripheral lymphoid tissues. Here we have investigated 1) whether SDF-1 stimulates the in vitro locomotion of follicular center lymphoma B cells and of their presumed normal counterparts (i. e., germinal center B cells) and 2) whether the same cells express SDF-1 transcripts. METHODS B cells were purified by immunomagnetic bead manipulation. Messenger RNA was detected by reverse transcription-polymerase chain reaction. Migration was assessed by the filter and collagen invasion assays. All P values were two sided. RESULTS Follicular center lymphoma B lymphocytes showed a statistically significant migratory response to 300 ng/mL SDF-1, both in the filter and in the collagen assays (P =.002 for each). Such response was mediated by the SDF-1 receptor, CXCR4. CD40 monoclonal antibody (MAb) and tonsillar germinal center B cells treated with CD40 MAb and recombinant interleukin 4, but not freshly isolated, migrated statistically significantly faster in the presence than in the absence of SDF-1 (P =.002 in both filter and collagen assays). Freshly isolated follicular center lymphoma and germinal center B cells expressed SDF-1 transcripts. CONCLUSIONS This study shows that SDF-1 substantially enhances the migration of follicular center lymphoma B cells but not the migration of freshly purified germinal center B cells. This difference may be related to the extended survival of follicular center lymphoma versus germinal center B cells. SDF-1 produced in follicular center lymphoma lymph nodes may play a role in the local dissemination of tumor cells.