Miracle-dz/UniFAR-FTUs huggingface dataset:
Cholinesterase Inhibitors in Mild Cognitive Impairment: A Systematic Review of Randomised Trials

Background Mild cognitive impairment (MCI) refers to a transitional zone between normal ageing and dementia. Despite the uncertainty regarding the definition of MCI as a clinical entity, clinical trials have been conducted in the attempt to study the role of cholinesterase inhibitors (ChEIs) currently approved for symptomatic treatment of mild to moderate Alzheimer disease (AD), in preventing progression from MCI to AD. The objective of this review is to assess the effects of ChEIs (donepezil, rivastigmine, and galantamine) in delaying the conversion from MCI to Alzheimer disease or dementia. Methods and Findings The terms “donepezil”, “rivastigmine”, “galantamine”, and “mild cognitive impairment” and their variants, synonyms, and acronyms were used as search terms in four electronic databases (MEDLINE, EMBASE, Cochrane, PsycINFO) and three registers: the Cochrane Collaboration Trial Register, Current Controlled Trials, and ClinicalTrials.gov. Published and unpublished studies were included if they were randomized clinical trials published (or described) in English and conducted among persons who had received a diagnosis of MCI and/or abnormal memory function documented by a neuropsychological assessment. A standardized data extraction form was used. The reporting quality was assessed using the Jadad scale. Three published and five unpublished trials met the inclusion criteria (three on donepezil, two on rivastigmine, and three on galantamine). Enrolment criteria differed among the trials, so the study populations were not homogeneous. The duration of the trials ranged from 24 wk to 3 y. No significant differences emerged in the probability of conversion from MCI to AD or dementia between the treated groups and the placebo groups. The rate of conversion ranged from 13% (over 2 y) to 25% (over 3 y) among treated patients, and from 18% (over 2 y) to 28% (over 3 y) among those in the placebo groups. Only for two studies was it possible to derive point estimates of the relative risk of conversion: 0.85 (95% confidence interval 0.64–1.12), and 0.84 (0.57–1.25). Statistically significant differences emerged for three secondary end points. However, when adjusting for multiple comparisons, only one difference remained significant (i.e., the rate of atrophy in the whole brain). Conclusions The use of ChEIs in MCI was not associated with any delay in the onset of AD or dementia. Moreover, the safety profile showed that the risks associated with ChEIs are not negligible. The uncertainty regarding MCI as a clinical entity raises the question as to the scientific validity of these trials.
Residual Thromboembolic Material in Cerebral Arteries after Endovascular Stroke Therapy Can Be Identified by Dual-Energy CT

BACKGROUND AND PURPOSE: Dual-energy CT features the opportunity to differentiate among up to 3 different materials because the absorption of x-rays depends on the applied tube voltage and the atomic number of the material. For example, it is possible to distinguish between blood-brain barrier disruption and an intracerebral hemorrhage following treatment for a stroke. The aim of this study was to evaluate whether dual-energy CT is capable of distinguishing intra-arterial contrast agent from residually clotted vessels immediately after endovascular stroke therapy. MATERIALS AND METHODS: Sixteen patients (9 women, 7 men; mean age, 63.6 ± 13.09 years) were examined. Measurements were made on the postinterventional dual-energy CT virtual noncontrast, iodine map, and “weighted” brain window (weighted dual-energy) series. Postinterventional conventional angiography was used as the criterion standard method. RESULTS: A residual clot was found in 10 patients. On the virtual noncontrast series, the Hounsfield attenuation of the clotted arteries was higher than that in the corresponding perfused contralateral arteries (53.72 ± 9.42 HU versus 41.64 ± 7.87 HU; P < .05). The latter had higher absorption values on the weighted dual-energy series than on the virtual noncontrast series (49.37 ± 7.44 HU versus 41.64 ± 7.87 HU; P < .05). The sensitivity for the detection of a residual clot was 90%; the specificity was 83.3%, and the accuracy was 87.5%. Interrater agreement was good (κ = 0.733). CONCLUSIONS: Dual-energy CT may be valuable in the detection of clot persistence or early re-thrombosis without the necessity of additional contrast administration. However, its relevance for the prediction of outcomes remains to be determined in further studies.
Tetralogy of Fallot and Hypoplastic Left Heart Syndrome – Complex Clinical Phenotypes Meet Complex Genetic Networks

In many cases congenital heart disease (CHD) is represented by a complex phenotype and an array of several functional and morphological cardiac disorders. These malformations will be briefly summarized in the first part focusing on two severe CHD phenotypes, hypoplastic left heart syndrome (HLHS) and tetralogy of Fallot (TOF). In most cases of CHD the genetic origin remains largely unknown, though the complexity of the clinical picture strongly argues against a dysregulation which can be attributed to a single candidate gene but rather suggests a multifaceted polygenetic origin with elaborate interactions. Consistent with this idea, genome-wide approaches using whole exome sequencing, comparative sequence analysis of multiplex families to identify de novo mutations and global technologies to identify single nucleotide polymorphisms, copy number variants, dysregulation of the transcriptome and epigenetic variations have been conducted to obtain information about genetic alterations and potential predispositions possibly linked to the occurrence of a CHD phenotype. In the second part of this review we will summarize and discuss the available literature on identified genetic alterations linked to TOF and HLHS.
Temporal pattern of online communication spike trains in spreading a scientific rumor: how often, who interacts with whom?

We study complex time series (spike trains) of online user communication while spreading messages about the discovery of the Higgs boson in Twitter. We focus on online social interactions among users such as retweet, mention, and reply, and construct different types of active (performing an action) and passive (receiving an action) spike trains for each user. The spike trains are analyzed by means of local variation, to quantify the temporal behavior of active and passive users, as a function of their activity and popularity. We show that the active spike trains are bursty, independently of their activation frequency. For passive spike trains, in contrast, the local variation of popular users presents uncorrelated (Poisson random) dynamics. We further characterize the correlations of the local variation in different interactions. We obtain high values of correlation, and thus consistent temporal behavior, between retweets and mentions, but only for popular users, indicating that creating online attention suggests an alignment in the dynamics of the two interactions.
Structured Output Layer neural network language model

This paper introduces a new neural network language model (NNLM) based on word clustering to structure the output vocabulary: Structured Output Layer NNLM. This model is able to handle vocabularies of arbitrary size, hence dispensing with the design of short-lists that are commonly used in NNLMs. Several softmax layers replace the standard output layer in this model. The output structure depends on the word clustering which uses the continuous word representation induced by a NNLM. The GALE Mandarin data was used to carry out the speech-to-text experiments and evaluate the NNLMs. On this data the well tuned baseline system has a character error rate under 10%. Our model achieves consistent improvements over the combination of an n-gram model and classical short-list NNLMs both in terms of perplexity and recognition accuracy.
Yeast Sequencing Report A 38 kb segment containing the cdc 2 gene from the left arm of ® ssion yeast chromosome II : sequence analysis and characterization of the genomic DNA and cDNAs encoded on the segment

MASAYUKI MACHIDA*, SHUJI YAMAZAKI, SUMIKO KUNIHIRO, TOSHIHIRO TANAKA, NORIHIRO KUSHIDA, KOUJI JINNNO, YUJI HAIKAWA, JUN YAMAZAKI, SAORI YAMAMOTO, MITSUO SEKINE, AKIO OGUCHI, YOSHIMI NAGAI, MARI SAKAI, KEN-ICHI AOKI, KEIKO OGURA, YUTAKA KUDOH, HISASHI KIKUCHI, MICHAEL Q. ZHANG AND MITSUHIRO YANAGIDA 1 Molecular Biology Department, National Institute of Bioscience and Human Technology, Higashi 1-1, Tsukuba, Ibaraki 305-8566, Japan 2 Biotechnology Center, National Institute of Technology and Evaluation, Nishihara 2-49-10, Shibuya-ku, Tokyo 151-0066, Japan 3 Cold Spring Harbor Laboratory, 1 Bungtown Road, PO Box 100, Cold Spring Harbor, NY 11724, USA 4 Department of Biophysics, Faculty of Science, Kyoto University, Sakyo-ku, Kyoto 606-8502, Japan
Endoscopic colorectal cancer screening: a cost-saving analysis.

BACKGROUND Comprehensive analyses have shown that screening for cancer usually induces net costs. In this study, the possible costs and savings of endoscopic colorectal cancer screening are explored to investigate whether the induced savings may compensate for the costs of screening. METHODS A simulation model for evaluation of colorectal cancer screening, MISCAN-COLON, is used to predict costs and savings for the U.S. population, assuming that screening is performed during a period of 30 years. Plausible baseline parameter values of epidemiology, natural history, screening test characteristics, and unit costs are based on available data and expert opinion. Important parameters are varied to extreme but plausible values. RESULTS Given the expert opinion-based assumptions, a program based on every 5-year sigmoidoscopy screenings could result in a net savings of direct health care costs due to prevention of cancer treatment costs that compensate for the costs of screening, diagnostic follow-up, and surveillance. This result persists when costs and health effects are discounted at 3%. The "break-even" point, the time required before savings exceed costs, is 35 years for a screening program that terminates after 30 years and 44 years for a screening program that continues on indefinitely. However, net savings increase or turn into net costs when alternative assumptions about natural history of colorectal cancer, costs of screening, surveillance, and diagnostics are considered. CONCLUSIONS Given the present, limited knowledge of the disease process of colorectal cancer, test characteristics, and costs, it may well be that the induced savings by endoscopic colorectal cancer screening completely compensate for the costs.
Molecular and Immunological Characterization of Staphylococcus aureus in Pediatric Atopic Dermatitis: Implications for Prophylaxis and Clinical Management

S. aureus represents a critical cofactor in atopic dermatitis (AD). In this paper, the prevalence of S. aureus infection/colonization was evaluated in 117 children as well as in their cohabitants, in order to assess the value of S. aureus characterization in predicting disease onset and severity and in providing indications for prophylaxis. Results showed that children with AD as well as their cohabitants had a significantly greater incidence of S. aureus infection/colonization as compared to controls. The genetic characterization showed a virtual identity of the bacteria strains collected at different sites of the patients with those found in the cohabitants, suggesting both a direct transmission between the nasal reservoir and the lesions in the same atopic subject and a risk for reinfection within family cohabitants. These data stress the need of preliminary laboratory assessment and posttherapy control in both AD patients and their close contacts for effective S. aureus eradication.
Liquidity Shocks, Banking System Failures, and Supranational Lending of Last Resort Facilities

In a small open economy with a high share of short term foreign currency denominated debt the arrival of some negative information on banks' investment returns may lead to severe bank runs. We analyse how a supranational institution which acts as an international lender of last resort can cope with banking crises by guaranteeing run-proof bank deposit contracts.
A bibliometric view on the internationalization of European educational research

Is there a trend towards internationalization of educational research in Europe? Educational research is said to follow a tradition of nationally oriented studies and interventions supported by a national publication culture. Publications are a suitable source of empirical analysis of research output, as they reflect results, emergence and impact of research. This study focuses on publication based bibliometric indicators, which represent measurable characteristics of international orientation of research publications and which can be surveyed in time course. Being aware that the Web of Science (WoS) databases cover a crucial but rather limited proportion of the worldwide educational research output, this study provides bibliometric insights into the development of national publication outputs in educational research in the WoS and what idiosyncrasies are revealed for European countries, into the role of English as a publication language, into the trend towards transnational co-authorship as an indicator of international cooperation, and into citation frequencies as a measurement of research communication or research impact.
Developmental mortality increases sex-ratio bias of a size-dimorphic bark beetle

1. Given sexual size dimorphism, differential mortality owing to body size can lead to sex‐biased mortality, proximately biasing sex ratios. This mechanism may apply to mountain pine beetles, Dendroctonus ponderosae Hopkins, which typically have female‐biased adult populations (2 : 1) with females larger than males. Smaller males could be more susceptible to stresses than larger females as developing beetles overwinter and populations experience high mortality.
A computational tool for coronary atherosclerotic plaque analysis of Virtual Histology images

Virtual Histology (IVUS-VH) is an image modality, derived from intravascular ultrasound (IVUS), which allows the identification of atheromatous components, providing a frame-by-frame tissue classification into four classes: Fibrotic Tissue, Fibro-Fatty Tissue, Necrotic-Core and Dense Calcium. According to current pathology consensus, intra-plaque spatial distribution of tissue elements has become an important issue for lesion classification. However, there is not an available environment to realize previously described analysis. To attend this demand, a computational tool has been implemented in this work. ImageJ has been used as development framework. Morphological operations and labeling algorithms of binary images were used to determine neighborhood relations between confluent sets of pixels, such as to measure distance to the arterial lumen. In the next months, we intend to distribute this tool for download under request.
Heterogeneity in the Production of Human Capital

We derive a tractable nonlinear earnings function which we estimate separately for each individual in the NLSY79 data. These estimates yield five important parameters for each individual: three ability measures (two representing the ability to learn and one the ability to earn), a rate of skill depreciation, and a time discount rate. In addition, we obtain a population wide estimate of the rental rate of human capital. To illustrate heterogeneity in the production of human capital, we plot the distribution of these parameters along with NLSY79 reported AFQT scores. By utilizing these parameters, we are able to verify a number of heretofore untested theorems based on the life-cycle human capital model. In addition, we are able to show how these human capital production function parameters relate to cognitive ability, personality traits, and family background. Among our results, we find: Black-white differences in ability are smaller than those exhibited in standardized tests. Blacks have higher time discount and skill depreciation rates than whites. Individuals with higher time discount rates and greater rates of skill depreciation have fewer years of school. Individuals with both a high internal locus of control and self-esteem exhibit greater ability, lower skill depreciation, and smaller time discount rates. Individuals inclined towards depression have higher time discount rates. Agreeable, open, conscientious and extrovert individuals have a greater ability to learn but not necessarily a greater ability to earn. Neurotic individuals have a lower ability to learn. Higher parental education is associated with a greater ability to learn, lower skill depreciation, and a smaller time discount rate. Educational stimuli, such as growing up in a household that subscribed to magazines, are associated with higher ability. Conversely, growing up poor is associated with lower ability.
Mobility and context-awareness in workflow systems

This project aims to describe how workflow systems can integrate and make use of context information from context rich environments, to enhance the execution of workflow processes. Context information can for example be used to control transitions between activities, activity enactment and process/activity coordination. A dynamic contextual environment also requires that a workflow system is capable of responding to contextual events. A set of requirements for a context-aware workflow system, based on existing workflow standards, theory behind context-aware computing and activity theory, will be presented and elaborated. Prototypes, which illustrate how these requirements can be implemented in a standard based workflow system, are also provided. Based on the solutions presented in the prototypes, a new interface for a workflow enactment service is presented. This new interface serves as the link between the contextual environment and the workflow system. We also present a solution for handling context related exception states. The definition of basic terms in workflow systems are expanded to better support context-aware behaviour. Ideas and solutions for more complex requirements not met in our prototypes are also discussed, such as situated activity coordination.
Semantic Changes – the Factors and Consequences of the Word Meaning Process

This paper covers the linguistic and non- linguistic phenomena of semantic changes. This paper aims to deal with the main factors, the nature and the consequences which bring to this semantic change of the word meaning.Using all the time a comparative approach, we have tried to address to four main factors and consequences of this change: internal linguistic factors, historical factors or cultural changes, social factors, psychological factors which can help us to understand the actual meaning of a word, illustrating them with relevant examples from both English and Albanian language.
Corpus COFLA

Flamenco is a music tradition from Southern Spain that attracts a growing community of enthusiasts around the world. Its unique melodic and rhythmic elements, the typically spontaneous and improvised interpretation, and its diversity regarding styles make this still largely undocumented art form a particularly interesting material for musicological studies. In prior works, it has already been demonstrated that research on computational analysis of flamenco music, despite it being a relatively new field, can provide powerful tools for the discovery and diffusion of this genre. In this article, we present corpusCOFLA, a data framework for the development of such computational tools. The proposed collection of audio recordings and metadata serves as a pool for creating annotated subsets that can be used in development and evaluation of algorithms for specific music information retrieval tasks. First, we describe the design criteria for the corpus creation and then provide various examples of subsets drawn from the corpus. We showcase possible research applications in the context of computational study of flamenco music and give perspectives regarding further development of the corpus.
Impact of Diabetes on Cardiac Sympathetic Innervation in Patients With Heart Failure

OBJECTIVE Impaired parasympathetic and sympathetic nervous system activity have been demonstrated in patients with diabetes mellitus (DM) and correlated with worse prognosis. Few data are available on the effect of DM on cardiac neuropathy in heart failure (HF). The aim of the current study was to assess cardiac sympathetic activity in HF patients with and without DM. RESEARCH DESIGN AND METHODS Patients with severe HF (n = 75), with (n = 37) and without DM (n = 38), and 14 diabetic patients with normal cardiac function underwent 123I meta-iodobenzylguanidine scintigraphy from which early and late heart-to-mediastinum (H/M) ratios were calculated. Clinical, echocardiographic, and biochemical data were measured. RESULTS DM compared with non-DM patients showed significantly lower early (1.65 ± 0.21 vs. 1.75 ± 0.21; P < 0.05) and late H/M ratios (1.46 ± 0.22 vs. 1.58 ± 0.24; P < 0.03). Early and late H/M were significantly higher in DM patients without HF (2.22 ± 0.35 and 1.99 ± 0.24, respectively) than HF patients with (P < 0.0001) and without (P < 0.0001) DM. In HF patients, an inverse correlation between early or late H/M ratio and hemoglobin A1c (HbA1c) (Pearson = −0.473, P = 0.001; Pearson = −0.382, P = 0.001, respectively) was observed. In DM, in multivariate analysis, HbA1c and ejection fraction remained significant predictors of early H/M; HbA1c remained the only significant predictor of late H/M. No correlation between early or late H/M and HbA1c was found in non-DM patients. CONCLUSIONS Diabetic patients with HF show lower cardiac sympathetic activity than HF patients not having DM or than DM patients with a similar degree of autonomic dysfunction not having HF. HbA1c correlated with the degree of reduction in cardiac sympathetic activity.
Simultaneous clock buffer sizing and polarity assignment for power/ground noise minimization

This work addresses the problem of minimizing power/ground noise in the clock tree synthesis. Contrary to the previous approaches which only make use of assigning polarities to clock buffers to reduce power/ground noise, our approach solves a new problem of simultaneous consideration of assigning polarities to clock buffers and determining buffer sizes to fully exploit the effects of buffer sizing together with polarity assignment on the minimization of power/ground noise while satisfying the clock skew constraint. Through experiments with MCNC benchmark circuits, it is shown that the proposed solution produces designs with 19.1% less power and 16.2% less ground noise as well as 15.6% less total peak current over that by the conventional method.