Miracle-dz/UniFAR-FTUs huggingface dataset:
Cognitive-behavioral intervention for homebound caregivers of persons with dementia.

BACKGROUND Family caregivers experience considerable stress in their management of specific behaviors of persons with dementia. OBJECTIVE To examine the effects of an 8-week cognitive-behavioral (C-B) intervention tailored to the specific deficits of persons with dementia (PWDs) on selected outcomes for homebound caregivers and the functional status of the PWD. METHOD The design was a two-group randomized trial with measures taken at baseline, 4 weeks, 8 weeks, and 12 weeks. Subjects were 65 caregiver-care recipient dyads. A majority of the 65 female caregivers were spouses with a mean age of 66.5 years. Thirty-one women who received the C-B intervention were compared to 34 who received the attention-only (A-O) placebo telephone calls. Coping strategies, perceptions of caregiver burden and satisfaction, and emotional and physical health were assessed at the four points in time. RESULTS Results indicated a time by group interaction in depression, with less depression in the C-B than the A-O group. Both groups experienced a significant reduction in anxiety, and a significant consistent decrease in satisfaction over time. Both groups also demonstrated decreased use of emotion-focused coping strategies. CONCLUSION The results suggest a plausible effectiveness of the C-B intervention in preventing the progression of depression. Suggestions for future research are provided.
Shear Shock Waves Observed in the Brain

The internal deformation of the brain is far more complex than the rigid motion of the skull. An ultrasound imaging technique that we have developed has a combination of penetration, frame-rate, and motion detection accuracy required to directly observe, for the first time, the formation and evolution of shear shock waves in the brain. Experiments at low impacts on the traumatic brain injury scale demonstrate that they are spontaneously generated and propagate within the porcine brain. Compared to the initially smooth impact, the acceleration at the shock front is amplified up to a factor of 8.5. This highly localized increase in acceleration suggests that shear shock waves are a fundamental mechanism for traumatic injuries in soft tissue.
Malfunctioning Peritoneal Dialysis Catheter Repaired by Laparoscopic Surgery

Objectives To review peritoneal dialysis catheter failures and to describe a technique of repairing malpositioned catheters. Design Two prospective case reports utilizing this technique are reported. Setting A tertiary care hospital. Patients Two patients on chronic peritoneal dialysis with malfunctioning catheters. Intervention Both patients underwent reposition of their malpositioned continuous ambulatory peritoneal dialysis catheters by laparoscopic suture technique. Main Outcome Measures Outcome was measured by the successful return of adequate peritoneal dialysis. Results Both case studies show correction of malpositioned catheters with the return of successful peritoneal dialysis. Conclusion The repositioning and suture application of malpositioned Tenckhoff catheters by laparoscopic surgery is a viabletechnique that can salvage the majority of mal positioned catheters and save the patients additional hospital time and recovery.
Characteristics of the Trends in the Global Tropopause Estimated From COSMIC Radio Occultation Data

This paper discusses the variabilities and trends in the global tropopause based on the gridded monthly mean Global Positioning System radio occultation data from the Constellation Observing System for Meteorology, Ionosphere, and Climate (COSMIC) mission during July 2006-February 2014. We find that the tropopause height can reflect El Niño-Southern Oscillation (ENSO) events. The correlation coefficient between global tropopause height anomalies and the Niño 3.4 sea surface temperature index is 0.53, with a maximum correlation coefficient of 0.8 at a lag of three months. We present first the detailed investigations about the spatial distribution of trends in tropopause parameters in each 10° × 5° longitude-latitude grid cell over the globe and find that the rates of change in the tropopause parameters during this time period are high in some particular regions such as the Southern Indian Ocean, Antarctica, Western Europe, North Pacific, and the east coast of North America. An analysis of global monthly means of the tropopause parameters indicates a global tropopause height increase of 0.03 ± 2.36 m/year during 2006-2014, with a corresponding temperature increase of 0.020 ± 0.008°C/year, and a pressure increase of 0.11 ± 0.059 hPa/year. The upward trend of tropopause height is significantly weaker than that in the past years, which might be attributed to the expected stratospheric ozone recovery associated with the Montreal Protocol, the global warming slowdown, and the abnormal global climate change in recent years. The trends of the tropopause parameters are the most significant over the Southern Indian Ocean and Antarctica during September/October/November, which could be due to the stratospheric ozone recovery.
Cellular Prion Protein Enhances Drug Resistance of Colorectal Cancer Cells via Regulation of a Survival Signal Pathway

Anti-cancer drug resistance is a major problem in colorectal cancer (CRC) research. Although several studies have revealed the mechanism of cancer drug resistance, molecular targets for chemotherapeutic combinations remain elusive. To address this issue, we focused on the expression of cellular prion protein (PrPC) in 5-FU-resistant CRC cells. In 5-FU-resistant CRC cells, PrPC expression is significantly increased, compared with that in normal CRC cells. In the presence of 5-FU, PrPC increased CRC cell survival and proliferation by maintaining the activation of the PI3K-Akt signaling pathway and the expression of cell cycle-associated proteins, including cyclin E, CDK2, cyclin D1, and CDK4. In addition, PrPC inhibited the activation of the stress-associated proteins p38, JNK, and p53. Moreover, after treatment of 5-FU-resistant CRC cells with 5-FU, silencing of PrPC triggered apoptosis via the activation of caspase-3. These results indicate that PrPC plays a key role in CRC drug resistance. The novel strategy of combining chemotherapy with PrPC targeting may yield efficacious treatments of colorectal cancer.
Effect of wheat bran and dried carrot pomace addition on quality characteristics of chicken sausage

Objective Effect of addition of wheat bran (WB) and dried carrot pomace (DCP) on sensory, textural, colour, physico-chemical and nutritional characteristics of chicken sausage were evaluated. Methods WB and DCP were used as a source of dietary fibre at 3%, 6%, and 9% level individually. Different quality attributes of sausages were estimated. One product from each source with very good sensory acceptability was selected to analyze dietary fibre content and shelf life under refrigerated storage. Results Sensory acceptability of 3% fibre enriched sausage was comparable with control and a further increase in fibre level resulted in a decrease in sensory acceptability. Fibre enriched sausages were significantly harder and less cohesive than control sausage. Significant increase in gumminess and chewiness was observed at 6% level in WB treated sausages and 9% level in DCP treated sausages. Moisture content decreased significantly in all treated sausages, protein content decreased significantly in DCP-2 and DCP-3 sausages while fat content decreased in all WB and DCP-3 treated sausages in comparison to control. The fibre enriched sausage had significantly higher dietary fibre and lower cholesterol content. Cooking yield and emulsion stability increased in treated sausages and a significant difference was noticed at 6% level in both types of sausages. pH of WB treated sausages was significantly higher and DCP treated sausage significantly lower in comparison to control. Conclusion The results of present study indicate that fibre enriched chicken sausage with moderate acceptability can be developed by incorporating WB and DCP each up to 9% level. Chicken sausage with very good acceptability, higher dietary fibre content and storability up to 15 days at refrigerated temperature can be developed by incorporating WB and DCP at 6% level each.
Unexpected spatial impact of treatment plant discharges induced by episodic hydrodynamic events: Modelling Lagrangian transport of fine particles by Northern Current intrusions in the bays of Marseille (France)

Our study highlights the Lagrangian transport of solid particles discharged at the Marseille Wastewater Treatment Plant (WWTP), located at Cortiou on the southern coastline. We focused on episodic situations characterized by a coastal circulation pattern induced by intrusion events of the Northern Current (NC) on the continental shelf, associated with SE wind regimes. We computed, using MARS3D-RHOMA and ICHTHYOP models, the particle trajectories from a patch of 5.104 passive and conservative fine particles released at the WWTP outlet, during 2 chosen representative periods of intrusion of the NC in June 2008 and in October 2011, associated with S-SE and E-SE winds, respectively. Unexpected results highlighted that the amount of particles reaching the vulnerable shorelines of both northern and southern bays accounted for 21.2% and 46.3% of the WWTP initial patch, in June 2008 and October 2011, respectively. Finally, a conceptual diagram is proposed to highlight the mechanisms of dispersion within the bays of Marseille of the fine particles released at the WWTP outlet that have long been underestimated.
The interleukin-23/interleukin-17 immune axis as a promising new target in the treatment of spondyloarthritis

Purpose of reviewVarious novel therapies for spondyloarthritis (SpA) are currently under development. In this review, we discuss the scientific rational to target the interleukin (IL)-23/IL-17 axis in SpA and give an overview of the proof-of-concept trials with drugs directed towards this axis. Recent findingsCumulative evidence from genetics (e.g. the strong genetic association with the IL-23 receptor gene), in-vitro models (e.g. the increased IL-23 production upon HLA-B27 misfolding), human expression studies (e.g. the expansion of IL-17 producing innate cells in SpA) and animal models (e.g. the increased IL-17 production in HLA-B27 transgenic rats) strongly supports the involvement of the IL-23/IL-17 axis in the pathogenesis of SpA. Ustekinumab (a monoclonal antibody directed against the common p40 subunit of IL-23 and IL-12), secukinumab, ixekizumab (both monoclonal antibodies directed against IL-17A), and brodalumab a monoclonal antibody against the IL-17RA receptor) have been recently used in proof-of-concept and randomized trials in the ankylosing spondylitis and/or psoriatic arthritis subforms of SpA, with overall very promising clinical efficacy. SummaryThe first results for novel drugs blocking key cytokines in the IL-23/IL-17 axis are promising in SpA and more novel compounds are upcoming. This will teach us more on the role of the IL-23/IL-17 axis in the pathophysiology of SpA.
New Caledonian Crows Rapidly Solve a Collaborative Problem without Cooperative Cognition

There is growing comparative evidence that the cognitive bases of cooperation are not unique to humans. However, the selective pressures that lead to the evolution of these mechanisms remain unclear. Here we show that while tool-making New Caledonian crows can produce collaborative behavior, they do not understand the causality of cooperation nor show sensitivity to inequity. Instead, the collaborative behavior produced appears to have been underpinned by the transfer of prior experience. These results suggest that a number of possible selective pressures, including tool manufacture and mobbing behaviours, have not led to the evolution of cooperative cognition in this species. They show that causal cognition can evolve in a domain specific manner–understanding the properties and flexible uses of physical tools does not necessarily enable animals to grasp that a conspecific can be used as a social tool.
Helping the Poor to Help Themselves: Debt Relief or Aid?

Debt relief is unlikely to stimulate investment and growth in the world's highly indebted poor countries (HIPCs). This is because the HIPCs do not suffer from debt overhang. The principal obstacle to investment and growth in the world's poorest countries is a lack of basic economic institutions that provide the foundation for profitable economic activity. If the goal is to help poor countries build the institutions that best suit their development needs, then the energy and resources currently devoted to the HIPC initiative could be more effectively employed as direct foreign aid.
A New Measurement for International Fragmentation of the Production Process: An International Input-Output Approach

The paper investigates the possibility of constructing a new measurement for analysing international fragmentation of the production process. It asserts that the current usage of relevant data, whether the trade shares of parts and components or the index of Vertical Specialisation, is quite unsatisfactory for measuring the phenomenon, since they critically lack the overall perspective of the entire structure of production chains. The new measurement is formulated such that it captures every aspect of the vertical sequence of production linkages. It is based on the input-output model of Average Propagation Lengths, recently developed by Eric Dietzenbacher and others, which show the average number of production stages that are passed through for an exogenous change in one industry to affect another. By applying this model to the data of the Asian International Input-Output Tables, the index is able to measure the international dimension of production sharing and division of labour in East Asia.
DC and AC Characterization of MgO Magnetic Tunnel Junction Sensors

We have fabricated multiple MgO magnetic tunnel junctions (MTJ) with 1.7 nm oxide, which are connected in series, and layed out in a serpentine geometry. We performed DC tunnel magnetoresistance measurements and AC impedance spectroscopy with crossed DC magnetic fields in the easy and hard axis directions. A simple RLC circuit model is used to fit our data and characterize the dependence on capacitance (C) and inductance (L) of magnetization orientation of the MTJ sensors. We have found in our samples that C and L are higher in antiparallel than in parallel configuration. We discuss possible reasons for the existence of this field dependence and show the evolution of magnetic field vs. capacitance curve from memory mode into sensing mode at high frequencies.
ACUTE RELEASE OF CATECHOLAMINES ON CIRCULATING BLOOD CELL ADRENOCEPTORS AND METABOLIC INDICES IN DOG

Summary— The effects of acute release of endogenous catecholamines on both platelet alpha2 and leukocyte beta adrenoreceptors and metabolic indices (glucose and free fatty acids) were investigated in dogs by means of a model of neurogenic hypertension following acute sinoaortic denervation (ASAD). Despite the marked increase in catecholamine levels (+4.2‐fold for noradrenaline and 16.7‐fold for adrenaline, for example, at minute 45 following ASAD) and in glucose plasma levels, and the significant decrease in free fatty acid plasma levels, no change in platelet alpha2 or leukocyte beta adrenoreceptor binding sites (number as well as affinity) was observed during the whole experiment. It is suggested that the number of platelet alpha2‐ and leukocyte beta‐adrenoreceptors is not submitted to short‐term regulation, at least by endogenous catecholamines in dogs.
Women’s experiences of exercise as a treatment for their postnatal depression: A nested qualitative study

Women with postnatal depression are often reluctant to take medication postnatally and access to psychological therapies is limited. Exercise offers a freely available treatment option but depressed mothers’ experience of exercise has not been investigated. We conducted a qualitative study nested within a randomised trial of an exercise intervention for women with postnatal depression. Women described deterioration in their sense of identity postnatally and through experiencing depression and described the positive impact exercise had on their sense of self. Views of exercise as treatment for postnatal depression ranged from doubts about its practicality to positive comparisons with other traditional treatments and to improved recovery.
Real and Inflationary Macroeconomic Risk in the Fama and French Size and Book-to-Market Portfolios

Based on evidence from 18 countries this paper finds that the Fama and French size (SMB) and book-to-market (HML) portfolios are correlated with future innovations in macroeconomic variables consistent with factor-mimicking portfolios of Merton (1973) ICAPM state variables. The analysis contributes to the literature by examining the performance of the Fama-French three-factor model relative to CAPM in international markets and showing that HML and SMB contain information regarding unexpected inflation distinct from that contained in the market factor. SMB is negatively correlated with inflation, and positively with real economic growth. HML is positively correlated with real GDP growth but inconsistently associated with inflation.This paper is superseded by "Macroeconomic Expectations and the Size, Value and Momentum Factors" by Mikael M. Bergbrant and Patrick J. Kelly and available at: http://ssrn.com/abstract=2571649
Motion artifact in studies of functional connectivity: Characteristics and mitigation strategies

Motion artifacts are now recognized as a major methodological challenge for studies of functional connectivity. As in‐scanner motion is frequently correlated with variables of interest such as age, clinical status, cognitive ability, and symptom severity, in‐scanner motion has the potential to introduce systematic bias. In this article, we describe how motion‐related artifacts influence measures of functional connectivity and discuss the relative strengths and weaknesses of commonly used denoising strategies. Furthermore, we illustrate how motion can bias inference, using a study of brain development as an example. Finally, we highlight directions of ongoing and future research, and provide recommendations for investigators in the field. Hum Brain Mapp, 40:2033–2051, 2019. © 2017 Wiley Periodicals, Inc.
Voltage-dependent inward currents in smooth muscle cells of skeletal muscle arterioles

Voltage-dependent inward currents responsible for the depolarizing phase of action potentials were characterized in smooth muscle cells of 4th order arterioles in mouse skeletal muscle. Currents through L-type Ca2+ channels were expected to be dominant; however, action potentials were not eliminated in nominally Ca2+-free bathing solution or by addition of L-type Ca2+ channel blocker nifedipine (10 μM). Instead, Na+ channel blocker tetrodotoxin (TTX, 1 μM) reduced the maximal velocity of the upstroke at low, but not at normal (2 mM), Ca2+ in the bath. The magnitude of TTX-sensitive currents recorded with 140 mM Na+ was about 20 pA/pF. TTX-sensitive currents decreased five-fold when Ca2+ increased from 2 to 10 mM. The currents reduced three-fold in the presence of 10 mM caffeine, but remained unaltered by 1 mM of isobutylmethylxanthine (IBMX). In addition to L-type Ca2+ currents (15 pA/pF in 20 mM Ca2+), we also found Ca2+ currents that are resistant to 10 μM nifedipine (5 pA/pF in 20 mM Ca2+). Based on their biophysical properties, these Ca2+ currents are likely to be through voltage-gated T-type Ca2+ channels. Our results suggest that Na+ and at least two types (T- and L-) of Ca2+ voltage-gated channels contribute to depolarization of smooth muscle cells in skeletal muscle arterioles. Voltage-gated Na+ channels appear to be under a tight control by Ca2+ signaling.
Regional price levels in Germany

Cross-sectional evidence on price levels is scarce for all countries. However, several studies suggest that there might exist considerable differences in price levels within countries, which has obvious welfare implications. A sample of price levels in 50 German cities in 1993 is used to analyse the determinants of inter-city price level differentials. The most important explanatory variables for price level differentials are population size and density and the average wage level. Using this information, the price levels are predicted in all 440 German districts and aggregated to the state level. At the state level convergence of the price levels to a common mean is found, but at a very low speed. The estimated half-life is about 19 years.
Effect of Recall Duration on Reporting of Household Expenditures: An Experimental Study in Ghana

A crucial issue in the design of household budget surveys is the length of the recall period for recalling transactions. It is known that the longer the recall period the greater the likely recall error, but on the other side a longer period makes it possible to cover a larger sample of transactions for a given number of interviews, and hence for a given field cost. This study arose from the needs of the Ghana Living Standards Survey (GLSS), a multi-purpose household survey sponsored by the World Bank and implemented by the Ghana Statistical Service, in which a key element is the estimation of detailed household expenditures. The GLSS design called for a 2-week recall period for each household, a period chosen essentially for logistic motives rather than in response to any evidence of recall efficiency. The authors prepared a minimal research proposal to test the issue and were able to obtain a research grant to conduct the experiment in Ghana. The design called for an experimental survey whose purpose was to investigate recall efficiency as a function of the length of the recall period, for expenditures on common articles by African households.
Metacarpal fixation.

This article discusses and categorizes common metacarpal fractures and their treatments, including various techniques of obtaining skeletal fixation. It reviews metacarpal shaft fracture; intra-articular metacarpal head fractures; and metacarpal neck and base fractures including carpal-metacarpal dislocations, and Rolando's and Bennett's fractures of the base of thumb metacarpal. Also discussed are the effects of shortening of lengthening the digital skeleton and bioabsorbable implants, a potential treatment modality currently under development.
Are there more than cross-sectional relationships of social support and support networks with functional limitations and psychological distress in early rheumatoid arthritis? the European Research on Incapacitating Diseases and Social Support Longitudinal Study.

OBJECTIVE To investigate whether greater social support and support network are cross-sectionally associated with less functional limitations and psychological distress in patients with early rheumatoid arthritis (RA); whether this association is constant over time; and whether increases in social support or support network are associated with less functional limitations and psychological distress. METHODS Subjects were from the European Research on Incapacitating Diseases and Social Support cohort and had early RA. Social support, support network, functional limitations (Health Assessment Questionnaire), and psychological distress (General Health Questionnaire) were assessed annually. Variance and covariance analyses with repeated measures were performed. RESULTS A total of 542 subjects were assessed for 3 years. On average, patients with a greater amount of specific social support or a stronger specific support network experienced less functional limitation and less psychological distress. Changes in a given subject's functional limitations and psychological distress did not depend on his or her baseline social support or support network. Neither social support nor support network change over time. CONCLUSION There may be a cross-sectional link between specific social support or support network and functional limitations and psychological distress, but no longitudinal association could be evidenced.