Miracle-dz/UniFAR-FTUs huggingface dataset:
Optical Coherence Tomography Angiography Features of Iris Racemose Hemangioma in 4 Cases

Importance Optical coherence tomography angiography (OCTA) allows visualization of iris racemose hemangioma course and its relation to the normal iris microvasculature. Objective To describe OCTA features of iris racemose hemangioma. Design, Setting, and Participants Descriptive, noncomparative case series at a tertiary referral center (Ocular Oncology Service of Wills Eye Hospital). Patients diagnosed with unilateral iris racemose hemangioma were included in the study. Main Outcomes and Measures Features of iris racemose hemangioma on OCTA. Results Four eyes of 4 patients with unilateral iris racemose hemangioma were included in the study. Mean patient age was 50 years, all patients were white, and Snellen visual acuity was 20/20 in each case. All eyes had sectoral iris racemose hemangioma without associated iris or ciliary body solid tumor on clinical examination and ultrasound biomicroscopy. By anterior segment OCT, the racemose hemangioma was partially visualized in all cases. By OCTA, the hemangioma was clearly visualized as a uniform large-caliber vascular tortuous loop with intense flow characteristics superimposed over small-caliber radial iris vessels against a background of low-signal iris stroma. The vascular course on OCTA resembled a light bulb filament (filament sign), arising from the peripheral iris (base of light bulb) and forming a tortuous loop on reaching its peak (midfilament) near the pupil (n = 3) or midzonal iris (n = 1), before returning to the peripheral iris (base of light bulb). Intravenous fluorescein angiography performed in 1 eye depicted the iris hemangioma; however, small-caliber radial iris vessels were more distinct on OCTA than intravenous fluorescein angiography. Conclusions and Relevance Optical coherence tomography angiography is a noninvasive vascular imaging modality that clearly depicts the looping course of iris racemose hemangioma. Optical coherence tomography angiography depicted fine details of radial iris vessels, not distinct on intravenous fluorescein angiography.
Perception of orthodontic treatment need among Swedish children, adolescents and young adults

Abstract Objective: Perceptions of orthodontic treatment need and perceptions of dental aesthetics was investigated among subjects ages 10, 15 and 19. Materials and methods: A total of 489 subjects completed a questionnaire after inspecting 10 photographs in the Aesthetic Component scale of the Index of Orthodontic Treatment Need to (i) reveal the lower limit for orthodontic treatment need and (ii) rate their dental aesthetics by selecting the most similar photo. Results: The mean lower limit for orthodontic treatment need was significantly higher (and closer to literature-based standards) among subjects, age 10 (4.2 ± 1.5), than among subjects, age 15 (3.6 ± 1.2) (p = .0009), and subjects, age 19 (3.5 ± 1.2) (p = .00002). Among subjects ages 15 and 19, the lower limit for orthodontic treatment need was lower in groups with (i) self-perceived orthodontic treatment need (p = .002 and .001, respectively) and (ii) previous orthodontic treatment (p = .005 and .035, respectively). Self-perceived orthodontic treatment need was present in more than one-third of subjects, age 19, who had previously received orthodontic treatment. Subjects of foreign origin reported that their dental aesthetics were worse (p = .002) and those same subjects, age 19, set the lower limit for orthodontic treatment lower (p = .047) than Swedes, age 19. Conclusions: The lower limit for orthodontic treatment need among subjects, age 10, was higher – compared to subjects, ages 15 and 19 – and closer to literature-based standards. Subjects with self-perceived orthodontic treatment need, subjects with previous orthodontic treatment, and subjects age 19 of foreign origin, have higher aesthetic demands.
Performance trends in age‐group runners from 100 m to marathon—The World Championships from 1975 to 2015

This study examined changes in performance in age‐group track runners across years from 1975 to 2015 for 100, 200, 400, 800, 1500, 5000, 10 000 m, and marathon and the corresponding sex differences. Athletes were ranked in 5‐year age‐group intervals from 35‐39 to 95‐99 years. For all races and all years, the eight female and male finalists for each age‐group were included. Men were faster than women and this observation was more pronounced in the shorter distances. The younger age‐groups were faster than the older age‐groups and age exerted the largest effect on speed in 800 m and the smallest in marathon. There was a small variation of speed by calendar years. The competition density varied by sex and race distance. Half of participants were from USA, Germany, Australia, and Great Britain, but the participants' nationality varied by sex and race distance. In summary, the variation of competitiveness by sex in short race distances might be important for athletes and coaches. Considering the event's competitiveness and that athletes are participating in both 100 and 200 m or in 200 and 400 m, master women should be oriented to 200 m and master men should be oriented to 100 and 400 m.
Responses of Nutrients and Mobile Carbohydrates in Quercus variabilis Seedlings to Environmental Variations Using In Situ and Ex Situ Experiments

Forest tree species distributed across a wide range of geographical areas are subjected to differential climatic and edaphic conditions and long-term selection, leading to genotypes with morphological and physiological adaptation to the local environment. To test the ability of species to cope with changing environmental conditions, we studied the ecophysiological features of Quercus variabilis using seedlings grown in geographically widely isolated populations (Exp. I, in situ) and in a common garden (Exp. II, ex situ) using seedlings originating from those populations. We found that Q. variabilis plants grown in different locations along a south-north gradient had different levels of nutrients (N, P, K) and carbon-physiological performance (photosynthesis, non-structural carbohydrates, such as soluble sugars and starch), and that these physiological differences were not correlated with local soil properties. These geographic variations of plant physiology disappeared when plants from different locations were grown in the same environment. Our results indicate that the physiological performance of Q. variabilis plants is mainly determined by the climatic variations across latitude rather than by their soils or by genetic differentiation. The adaptive ability of Q. variabilis found in the present study suggests that this species has the potential to cope, at least to some extent, with changing environmental conditions.
Enhancement of oral bioavailability of cyclosporine A: comparison of various nanoscale drug-delivery systems

A variety of nanoscale delivery systems have been shown to enhance the oral absorption of poorly water-soluble and poorly permeable drugs. However, the performance of these systems has seldom been evaluated simultaneously. The aim of this study was to compare the bioavailability enhancement effect of lipid-based nanocarriers with poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) to highlight the importance of the lipid composition, with cyclosporine A (CyA) as a model drug. CyA-loaded PLGA NPs, nanostructured lipid carriers (NLCs), and self-microemulsifying drug-delivery systems (SMEDDS) were prepared. The particle size of PLGA NPs (182.2±12.8 nm) was larger than that of NLCs (89.7±9.0 nm) and SMEDDS (26.9±1.9 nm). All vehicles are charged negatively. The entrapment efficiency of PLGA NPs and NLCs was 87.6%±1.6% and 80.3%±0.6%, respectively. In vitro release tests indicated that the cumulative release of CyA was lower than 4% from all vehicles, including Sandimmun Neoral®, according to the dialysis method. Both NLCs and SMEDDS showed high relative oral bioavailability, 111.8% and 73.6%, respectively, after oral gavage administration to beagle dogs, which was not statistically different from commercial Sandimmun Neoral®. However, PLGA NPs failed to achieve efficient absorption, with relative bioavailability of about 22.7%. It is concluded that lipid-based nanoscale drug-delivery systems are superior to polymeric NPs in enhancing oral bioavailability of poorly water-soluble and poorly permeable drugs.
The variations on the aerodynamics of a world-ranked wheelchair sprinter in the key-moments of the stroke cycle: A numerical simulation analysis

Biomechanics plays an important role helping Paralympic sprinters to excel, having the aerodynamic drag a significant impact on the athlete’s performance. The aim of this study was to assess the aerodynamics in different key-moments of the stroke cycle by Computational Fluid Dynamics. A world-ranked wheelchair sprinter was scanned on the racing wheelchair wearing his competition gear and helmet. The sprinter was scanned in three different positions: (i) catch (hands in the 12h position on the hand-rim); (ii) the release (hands in the 18h position on the hand-rim) and; (iii) recovery phase (hands do not touch the hand-rim and are hyperextended backwards). The simulations were performed at 2.0, 3.5, 5.0 and 6.5 m/s. The mean viscous and pressure drag components, total drag force and effective area were retrieved after running the numerical simulations. The viscous drag ranged from 3.35 N to 2.94 N, pressure drag from 0.38 N to 5.51 N, total drag force from 0.72 N to 8.45 N and effective area from 0.24 to 0.41 m2. The results pointed out that the sprinter was submitted to less drag in the recovery phase, and higher drag in the catch. These findings suggest the importance of keeping an adequate body alignment to avoid an increase in the drag force.
PCB-126 effects on aryl hydrocarbon receptor, ubiquitin and p53 expression levels in a fish product (Sparus aurata L.)

Abstract The aim of the present study is to determine if Ahr ligands as PCB-126, a dioxin-like, might contribute to inhibition of the tumour suppressor p53 by promoting its degradation through proteasome-ubiquitin system (UPS). The findings show, in the presence of PCB-126, a significant increase in p53 immunoreactivity in fish compared to the control. Subsequently, there is a decrease in p53 immunoreactivity at 24 h which is maintained even at 72 h. There is also a slight decrease in ubiquitin immunoreactivity to 12 h compared to the control and a marked decrease to 24 and 72 h. It’s very important to underline as in this study we demonstrate a marked decrease in ubiquitin and p53 immunoreactivity at 24 and 72 h. Our result emphasise the need to deeply the role of this receptor in UPS regulation as potential therapeutic target for cancer treatment.
Testing Species Delimitations in Four Italian Sympatric Leuciscine Fishes in the Tiber River: A Combined Morphological and Molecular Approach

Leuciscine fishes represent an important component of freshwater ichthyofauna endemic to northern Mediterranean areas. This lineage shows high intra-specific morphological variability and exhibits high levels of hybridization, two characteristics that contribute to systematic uncertainties, misclassification of taxa and, potentially, the mismanagement of biodiversity. This study focused on brook chub, Squalius lucumonis, an endemic taxon of Central Italy. The taxonomic status of this species has long been questioned, and a hybrid origin from sympatric leusciscines (S. squalus x Rutilus rubilio, or S. squalus x Telestes muticellus) has been hypothesised. A phenotypic (evaluating shape and meristic counts) and genetic (using mitochondrial and nuclear markers) investigation of these four taxa was conducted to test species delimitation in sympatric areas and to evaluate the taxonomic status of S. lucumonis. One hundred and forty-five individuals of all four taxa were collected within streams of the lowest portion of the Tiber River basin and analysed; this region encompasses a large portion of the S. lucumonis distribution. The different morphological and genetic approaches were individually examined, compared, and then combined in a quantitative model to both investigate the limits of each approach and to identify cases of misclassification. The results obtained confirm the cladogenetic non-hybrid origin of S. lucumonis, highlight the need for immediate conservation actions and emphasise the value of an integrated approach in the study of leuciscines evolution.
Elevated Serum Ferritin Level Is Associated with the Incident Type 2 Diabetes in Healthy Korean Men: A 4 Year Longitudinal Study

Background Elevated ferritin concentration has been implicated in the etiology of type 2 diabetes. Accumulating evidence, mostly from studies conducted on western populations, has demonstrated a strong association between the elevated ferritin concentrations and incident type 2 diabetes. In Asian populations, however, the longitudinal studies investigating the association of elevated serum ferritin levels and type 2 diabetes are lacking. In present study, we aimed to determine whether elevated serum ferritin levels are related to the incident type 2 diabetes in healthy Korean men. Methodology/Principal Findings This 4 year longitudinal observational study was conducted at the Asan Medical Center, Seoul, Republic of Korea. The study population consisted of 2,029 men without type 2 diabetes who underwent routine health examination in 2007 (baseline) and 2011 (follow-up). Baseline serum ferritin concentrations were measured by chemiluminescent two-site sandwich immunoassay. In multiple-adjusted model, the relative risk (RR) for incident type 2 diabetes was significantly higher in highest compared with the lowest ferritin quartile category, even after adjusting for confounding variables including homeostasis model assessment of insulin resistance (RR = 2.17, 95% confidence interval 1.27–3.72, P for trend = 0.013). Conclusions/Significance These results demonstrated that elevated level of serum ferritin at baseline was associated with incident type 2 diabetes in an Asian population.
HUMAN TOXOPLASMOSIS OUTBREAKS AND THE AGENT INFECTING FORM. FINDINGS FROM A SYSTEMATIC REVIEW

SUMMARY Toxoplasmosis, a worldwide highly prevalent zoonotic infection, is transmitted either by the oocysts, from water and soil, or the tissue cysts, in raw or undercooked infected meat, of Toxoplasma gondii. An ongoing debate is whether there are differences between the clinical and epidemiological characteristics of the outbreaks due to one or the other infective form of the agent. We performed a systematic review, recovering 437 reported outbreaks of which 38 were selected. They were complete reports containing ascribedToxoplasma infecting form, and clinical and demographic data. There was no gender or age group selection in the outbreaks, which were described more often in the Americas. A large number of individuals were affected when oocysts, associated with soil and water contaminated with cat feces, were considered the transmission source. Onset of symptoms occurred early when the infection was ascribed to meat tissue cysts (11.4 ± 6.7 days) with sharpened temporal distribution of cases, while a broader and prolonged appearance of new cases was observed when oocysts in water were the source of the infection (20 ± 7 days, p < 0.001). Such information may be useful in the design and implementation of control strategies.
Contrasting Evolutionary Dynamics of the Developmental Regulator PAX9, among Bats, with Evidence for a Novel Post-Transcriptional Regulatory Mechanism

Morphological evolution can be the result of natural selection favoring modification of developmental signaling pathways. However, little is known about the genetic basis of such phenotypic diversity. Understanding these mechanisms is difficult for numerous reasons, yet studies in model organisms often provide clues about the major developmental pathways involved. The paired-domain gene, PAX9, is known to be a key regulator of development, particularly of the face and teeth. In this study, using a comparative genetics approach, we investigate PAX9 molecular evolution among mammals, focusing on craniofacially diversified (Phyllostomidae) and conserved (Vespertilionidae) bat families, and extend our comparison to other orders of mammal. Open-reading frame analysis disclosed signatures of selection, in which a small percentage of residues vary, and lineages acquire different combinations of variation through recurrent substitution and lineage specific changes. A few instances of convergence for specific residues were observed between morphologically convergent bat lineages. Bioinformatic analysis for unknown PAX9 regulatory motifs indicated a novel post-transcriptional regulatory mechanism involving a Musashi protein. This regulation was assessed through fluorescent reporter assays and gene knockdowns. Results are compatible with the hypothesis that the number of Musashi binding-elements in PAX9 mRNA proportionally regulates protein translation rate. Although a connection between morphology and binding element frequency was not apparent, results indicate this regulation would vary among craniofacially divergent bat species, but be static among conserved species. Under this model, Musashi’s regulatory control of alternative human PAX9 isoforms would also vary. The presence of Musashi-binding elements within PAX9 of all mammals examined, chicken, zebrafish, and the fly homolog of PAX9, indicates this regulatory mechanism is ancient, originating basal to much of the animal phylogeny.
Solid state fermentation of apple pomace for the production of value added products

Food industry in general, generates a large quantity of waste (i.e. peel, seed, pomace, rags, kernels, etc.) which is biodegradable in nature. Due to richness in carbohydrates, dietary fibres and minerals, such wastes have the potential to support the growth of microorganisms involved in the production of various products. Laboratory scale solid state fermentation (SSF) of waste from apple processing industry revealed the possibility of production of several value added products. Solid state fermentation of apple pomace by Saccharomyces cerevisiae and removal of ethanol followed by drying increase the nitrogen and fat content in the fermented and dried apple pomace for use as an animal feed. S. cerevisiae, in sequential interactive culture improve the soluble protein content of the fermented apple pomace. The product (animal feed) could successfully be fed to the poultry after mixing with standard feed in the ratio of 1:1. SSF of apple pomace using Aspergillus niger yield pectin esterase enzyme much more than submerged fermentation. Production of different biocolours by fermentation with Chromobacter sp. , Sarcina sp. , Rhodotorula sp. and Micrococcus sp. is possible along with citric acid production in SSF by A. niger, all having commercial value. Apple pomace utilization can become a model for the value addition of similar wastes and development of solid state fermenter and downstream processing will go a long way in developing technology from laboratory to pilot scale. In the present paper authors have summarized various research reports and their work on solid state fermentation of apple pomace and the production of value added products.
Development of dental anxiety in schoolchildren: A 2‐year prospective study

AIM To assess the development of high dental anxiety and the factors that are associated with it over a 2-year period. DESIGN This longitudinal study focused on 416 Brazilian children aged 5-7 years over 2 years. Interviews were conducted with the children's parents to investigate the children's health-related behaviours. Additionally, the children's dental caries experience was clinically evaluated to obtain information about DMFT/dmft (decayed, filled and missing teeth) indices. Using the Dental Anxiety Question, children whose parents responded "yes" to the prompt "Is he/she very afraid of going to the dentist? " were classified as having high dental anxiety. Multilevel mixed-effects logistic regression was used to analyse factors to determine the extent to which they were associated with high dental anxiety longitudinally. RESULTS The prevalence of high dental anxiety in children at baseline was 16.2%, whereas it was 19.8% at follow-up. Additionally, 38% of the children with high dental anxiety at baseline still had the condition after two years, although 62% of them no longer had high dental anxiety. The incidence of high dental anxiety at 2-year follow-up was 15.0%. Children who used medication chronically had a 2.1 times greater likelihood of having high dental anxiety. Furthermore, children whose parents reported high dental anxiety had a 2.6 times greater likelihood of having high dental anxiety themselves. A one-unit increase in a child's dmft score increased the risk of high dental anxiety by 1.1 times at follow-up. CONCLUSION After two years, the incidence of high dental anxiety was 15.0%. Poor oral health, unstable general health and parents with high dental anxiety were factors that were associated with this type of anxiety in schoolchildren. It is important that dentists are aware of children's high dental anxiety and the associated factors so that they can appropriately intervene. Dentists fulfil an important role and should stimulate and promote good general hygiene habits that may prevent future problems.
The influence of different pH of saliva and thermal cycling on the adaptation of different denture base materials

The difference in the adaptation of denture bases processed from heat cure acrylic, light cure acrylic and nylon materials and the effect of artificial accelerated aging (thermal cycling and pH) on the adaptation was studied. Materials and methods: One hundred eighty stone cast were prepared and assigned into 3 main groups according to the denture base material that processed on them(heat cure, light cure, nylon), each denture base and its cast was sectioned at posterior palatal border and the gap between the denture base and the cast was measured using digital microscope. Half of each group exposed to thermal cycling (2000 cycle) between (5 C-55 C ) 30 second in each bath then the adaptation was evaluated again. All denture bases were stored in artificial saliva of different pH (5.7, 7,8.3) at 37 C for 30 days, then the adaptation was measured again. Results and discussions: The results showed that the adaptation of heat cure acrylic was better than light cure and nylon before and after aging process. The nylon showed the poorest adaptation. Thermal cycling decreases the adaptation of all denture bases. Variation of pH effected the adaptation of heat cure and light cure denture bases and did not affect the adaptation of nylon.
INTERPERSONAL RELATIONS AND GROUP PROCESSES Providing Help and Desired Relationship Type as Determinants of Changes in Moods and Self-Evaluations

Observed in 2 initial studies was converging evidence that helping improves the helpers' moods and self-evaluations. In these studies Ss induced to help showed improved moods and self-evaluations relative to Ss not given an opportunity to help. A 3rd study examined the moderating effects of desired relationship type on reactions to having helped. In this study Ss were led to desire either a communal or an exchange relationship with another. They then helped the other or were not allowed to help. Among Ss led to desire a communal relationship, but not among those led to desire an exchange relationship, helping was associated with greater improvements in moods than not helping. Helping tended to improve self-evaluations regardless of desired relationship type. However, this effect reached statistical significance only among subjects led to desire a communal relationship.