Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of dietary antioxidant vitamins on lung functions according to gender and smoking status in Korea: a population-based cross-sectional study

Objective Cigarette smoke-induced oxidative stress plays an important role in the pathogenesis of chronic obstructive pulmonary disease (COPD). Dietary antioxidants are thought to prevent smoke-induced oxidative damage. The aim of this study was to investigate associations between lung function and the consumption of antioxidant vitamins in Korean adults. Methods In total, 21 148 participants from the Korean National Health and Nutrition Examination Survey (2007–2014) were divided into four groups based on smoking history and gender. Multivariate regression models were used to evaluate associations between lung function and intake of dietary antioxidants. Results Subjects in the highest intake quintile (Q5) of vitamin A, carotene and vitamin C intake had mean forced expiratory volume in 1 s (FEV1) measurements that were 30 mL, 32 mL and 36 mL higher than those of individuals in the lowest intake quintile (Q1), respectively (p for trend; p=0.008, p=0.010 and p<0.001, respectively). The risks of COPD for male smokers in Q1 increased 7.60-fold (95% CI 5.92 to 9.76), 7.16-fold (95% CI 5.58 to 9.19) and 7.79-fold (95% CI 6.12 to 9.92), for vitamin A, carotene and vitamin C, respectively, compared with those of female non-smokers in Q5. Among patients with COPD, men who smoked >20 pack-years had mean FEV1 measurements that were 192 mL, 149 mL and 177 mL higher than those of patients in Q1 (p for trend; p=0.018, p=0.024 and p=0.043, for vitamin A, carotene and vitamin C, respectively). Conclusions These findings indicate that the influence of antioxidant vitamins on lung function depends on gender and smoking status in the Korean COPD population.
Soleus muscle stability in wild hibernating black bears.

Based on studies of fast skeletal muscles, hibernating black and brown bears resist skeletal muscle atrophy during months of reduced physical activity and not feeding. The present study examined atrophy sparing in the slow soleus muscle, known to be highly prone to disuse atrophy in humans and other mammals. We demonstrated histochemically that the black bear soleus is rich in slow fibers, averaging 84.0 ± 6.6%. The percentages of slow fibers in fall (87.3 ± 4.9%) and during hibernation (87.1 ± 5.6%) did not differ ( P = 0.3152) from summer. The average fiber cross-sectional area to body mass ratio (48.6 ± 11.7 µm2/kg) in winter hibernating bears was not significantly different from that of summer (54.1 ± 11.8 µm2/kg, P = 0.4186) and fall (47.0 ± 9.7 µm2/kg, P = 0.9410) animals. The percentage of single hybrid fibers containing both slow and fast myosin heavy chains, detected biochemically, increased from 2.6 ± 3.8% in summer to 24.4 ± 24.4% ( P = 0.0244) during hibernation. The shortening velocities of individual hybrid fibers remained unchanged from that of pure slow and fast fibers, indicating low content of the minority myosins. Slow and fast fibers in winter bears exhibited elevated specific tension (kN/m2; 22%, P = 0.0161 and 11%, P = 0.0404, respectively) and maintained normalized power. The relative stability of fiber type percentage and size, fiber size-to-body mass ratio, myosin heavy chain isoform content, shortening velocity, power output, and elevated specific tension during hibernation validates the ability of the black bear to preserve the biochemical and performance characteristics of the soleus muscle during prolonged hibernation.
Dust and PAH Emission in the Star-forming Active Nucleus of NGC 1097

The nucleus of the nearby galaxy NGC 1097 is known to host a young, compact (r < 9 pc) nuclear star cluster, as well as a low-luminosity active galactic nucleus (AGN). It has been suggested both that the nuclear stellar cluster is associated with a dusty torus and that low-luminosity AGNs like NGC 1097 do not have the torus predicted by the unified model of AGNs. To investigate these contradictory possibilities we have acquired Gemini/T-ReCS 11.7 and 18.3 μm images of the central few hundred parsecs of this galaxy at <45 pc angular resolution, in which the nucleus and spectacular, kiloparsec-scale star-forming ring are detected in both bands. The small-scale mid-IR luminosity implies thermal emission from warm dust close to the central engine. Fitting of torus models shows that the observed mid-IR emission cannot be accounted for by dust heated by the central engine. Rather, the principal source heating the dust in this object is the nuclear star cluster itself, suggesting that the detected dust is not the torus of AGN unified schemes (although it is also possible that the dusty starburst itself could provide the obscuration invoked by the unified model). Comparison of Spitzer IRS and Gemini GNIRS spectra shows that, although PAH bands are strong in the immediate circumnuclear region of the galaxy, PAH emission is weak or absent in the central 19 pc. The lack of PAH emission can probably be explained largely by destruction/ionization of PAH molecules by hard photons from the nuclear star cluster. If NGC 1097 is typical, PAH emission bands may not be a useful tool with which to find very compact nuclear starbursts even in low-luminosity AGNs.
Pediatric cirrhotic cardiomyopathy: Impact on liver transplant outcomes

In adults, cirrhotic cardiomyopathy (CCM) has a significant incidence and impact on liver transplantation. For pediatric liver transplantation (pLT), data on liver‐induced cardiac changes are scarce, and in particular, the comparison between cirrhotic and noncirrhotic liver disease has not been investigated. We retrospectively evaluated cardiac changes associated with CCM by echocardiography and 12‐lead electrocardiogram in 198 pLT‐candidates (median age 4.1 years) 4.2 before and 12 months after pLT. Results were correlated with the stage of liver fibrosis and cholestasis before transplantation. The left ventricular end‐diastolic diameter (LVIDd) z score, left ventricular mass z score, and left ventricular mass index were significantly higher in cirrhotic patients (‐0.10 versus 0.98, P < 0.001; ‐1.55 versus ‐0.42, P = 0.001; 78.99 versus 125.64 g/m2, P = 0.001, respectively) compared with children with noncirrhotic liver disease. Pathological z scores (>2SDS) for the LVIDd occurred more frequently in cirrhotic patients compared with patients with noncirrhotic liver disease (31/169 versus 1/29; P = 0.03) and were significantly associated with cholestasis. All observed cardiac changes were reversible 1 year after pLT. Pathological LVIDd z scores correlated highly with intensive care unit (ICU) stay (9.6 days versus 17.1 days, respectively, P = 0.002) but not with patient survival pre‐LT or post‐LT. In contrast to other studies, prolonged QTc time was not associated with liver cirrhosis in our patients. In conclusion, CCM‐associated cardiac changes in pLT candidates with cirrhotic liver disease are frequent, mild, and associated with cholestasis and reversible after pLT. They may impact peritransplant care and posttransplant hospitalization time. Further prospective evaluation is warranted. In particular, for QTc time prolongation etiological factors, possible protective effects of ursodeoxycholic acid treatment and the use as a screening parameter for CCM should be verified. Liver Transplantation 24 820–830 2018 AASLD.
Photolithographic-stereolithographic-tandem fabrication of 4D smart scaffolds for improved stem cell cardiomyogenic differentiation

4D printing is a highly innovative additive manufacturing process for fabricating smart structures with the ability to transform over time. Significantly different from regular 4D printing techniques, this study focuses on creating novel 4D hierarchical micropatterns using a unique photolithographic-stereolithographic-tandem strategy (PSTS) with smart soybean oil epoxidized acrylate (SOEA) inks for effectively regulating human bone marrow mesenchymal stem cell (hMSC) cardiomyogenic behaviors. The 4D effect refers to autonomous conversion of the surficial-patterned scaffold into a predesigned construct through an external stimulus delivered immediately after printing. Our results show that hMSCs actively grew and were highly aligned along the micropatterns, forming an uninterrupted cellular sheet. The generation of complex patterns was evident by triangular and circular outlines appearing in the scaffolds. This simple, yet efficient, technique was validated by rapid printing of scaffolds with well-defined and consistent micro-surface features. A 4D dynamic shape change transforming a 2-D design into flower-like structures was observed. The printed scaffolds possessed a shape memory effect beyond the 4D features. The advanced 4D dynamic feature may provide seamless integration with damaged tissues or organs, and a proof of concept 4D patch for cardiac regeneration was demonstrated for the first time. The 4D-fabricated cardiac patch showed significant cardiomyogenesis confirmed by immunofluorescence staining and qRT-PCR analysis, indicating its promising potential in future tissue and organ regeneration applications.
Volume constancy and material continuity in metal cutting

The volume constancy and material continuity in metal cutting are analysed. It is shown that the main equations of the chip formation (Time's and Ernst-Merchant's expressions) introduce the volume constancy, but do not define the material continuity. The condition of material continuity is understood as the coincidence of the chip compression ratio defined by the main equations with the corresponding strain calculated through the micro strains in the chip and their orientations relative to the chip axes. Therefore, among a great number of volume constancy solutions, the one is chosen satisfying the material continuity condition. The approach proposed is validated by the corrected interpretation of the main equations of the chip formation, by the shear angle prediction and by the in-plane shear residual stress prediction.
Multi-task Learning Using Uncertainty to Weigh Losses for Scene Geometry and Semantics

Numerous deep learning applications benefit from multitask learning with multiple regression and classification objectives. In this paper we make the observation that the performance of such systems is strongly dependent on the relative weighting between each task's loss. Tuning these weights by hand is a difficult and expensive process, making multi-task learning prohibitive in practice. We propose a principled approach to multi-task deep learning which weighs multiple loss functions by considering the homoscedastic uncertainty of each task. This allows us to simultaneously learn various quantities with different units or scales in both classification and regression settings. We demonstrate our model learning per-pixel depth regression, semantic and instance segmentation from a monocular input image. Perhaps surprisingly, we show our model can learn multi-task weightings and outperform separate models trained individually on each task.
Effect of Emailed Messages on Return Use of a Nutrition Education Website and Subsequent Changes in Dietary Behavior

Background At-risk populations can be reached with Web-based disease prevention and behavior change programs. However, such eHealth applications on the Internet need to generate return usage to be effective. Limited evidence is available on how continued usage can be encouraged. Objective This analysis tested whether routine email notification about a nutrition education website promoted more use of the website. Methods Adults from six rural counties in Colorado and New Mexico, United States (n = 755) participating in a randomized trial and assigned to the intervention group (n = 380) received, over a period of 4 months, email messages alerting them to updates on the website, along with hyperlinks to new content. Update alerts were sent approximately every 5 weeks (each participant received up to 4 messages). Log-ons to the website were the primary outcome for this analysis. Results A total of 23.5% (86/366) of the participants responded to at least one email, and 51.2% (44/86) of these participants responded to half of the email messages by logging on to the website. Significantly more log-ons occurred on email notification days compared to all other days (OR = 3.71, 95% CI = 2.72-5.06). More log-ons also occurred just after the notification but declined each day thereafter (OR = 0.97, 95% CI = 0.96-0.98 one day further from mass email). Non-Hispanics (OR = 0.46, 95% CI = 0.26-0.84), older participants (OR = 1.04, 95% CI = 1.04-1.06), and those using the Internet most recently (OR = 0.62, 95% CI = 0.51-0.77) were more likely to log on. Responders to the messages had a more positive change in fruit and vegetable intake (mean change = +1.69) than nonresponders (+0.05), as measured with a food frequency assessment (adjusted Spearman partial correlation coefficient = 0.14, P = .049). Compared to nonresponders, responders were more likely to be non-Hispanic (P = .01), older (P < .001), and had used the Internet more recently (P < .001). Conclusions Messages sent by email appeared to promote a modest short-lived increase in use of a disease prevention website by some adults. Those who responded to the messages by logging on to the website may have been influenced to improve their diet.
Beyond the Fokker-Planck equation: pathwise control of noisy bistable systems

We introduce a new method, allowing one to describe slowly time-dependent Langevin equations through the behaviour of individual paths. This approach yields considerably more information than the computation of the probability density. In particular, scaling laws can be obtained easily. The main idea is to show that for sufficiently small noise intensity and slow time dependence, the vast majority of paths remain in small space-time sets, typically in the neighbourhood of potential wells. The size of these sets often has a power-law dependence on the small parameters, with universal exponents. The overall probability of exceptional paths is exponentially small, with an exponent also showing power-law behaviour. The results cover time spans up to the maximal Kramers time of the system. We apply our method to three phenomena characteristic for bistable systems: stochastic resonance, dynamical hysteresis and bifurcation delay, where it yields precise bounds on transition probabilities, and the distribution of hysteresis areas and first-exit times. We also discuss the effect of coloured noise.
Design, preparation and in vitro evaluation of paclitaxel-loaded self-nanoemulsifying drug delivery system

Paclitaxel has been widely used as an anticancer drug for clinical chemotherapy. However, to overcome its poor water solubility, a new self-nanoemulsifying drug delivery system (SNEDDS) was developed and the characteristics in vitro were evaluated. Compositions of SNEDDS formulation were screened via solubility studies of paclitaxel and compatibility tests. A pseudoternary phase diagrams was used to optimize the formulation. The optimal formulation of SNEDDS consisted of 60% surfactant (Cremophor ELP), 20% cosurfactant (PEG400) and 20%oil (isopropyl myristate, IPM). In vitro release test showed that more than 99% of paclitaxel release from SNEDDS in approximately 4 h. The drug release from SNEDDS was dramatically enhanced compared with that of the suspension. Our study illustrated that the developed SNEDDS formulation held great potential for the oral route.
The adaptive value of heterospory: Evidence from Selaginella

Heterospory was a pivotal evolutionary innovation for land plants, but it has never been clear why it evolved. We used the geographic distributions of 114 species of the heterosporous lycophyte Selaginella to explore the functional ecology of microspore and megaspore size, traits that would be correlated with many aspects of a species’ regeneration niche. We characterized habitats at a global scale using leaf area index (LAI), a measure of foliage density and thus shading, and net primary productivity (NPP), a measure of growth potential. Microspore size tends to decrease as habitat LAI and NPP increase, a trend that could be related to desiccation resistance or to filtration of wind‐borne particles by leaf surfaces. Megaspore size tends to increase among species that inhabit regions of high LAI, but there is an important interaction with NPP. This geographical pattern suggests that larger megaspores provide an establishment advantage in shaded habitats, although in open habitats, where light is less limiting, higher productivity of the environment seems to give an advantage to species with smaller megaspores. These results support previous theoretical arguments that heterospory was originally an adaptation to the increasing height and density of Devonian vegetative canopies that accompanied the diversification of vascular plants with leaves.
The Herbst appliance and the Activator: influence of the vertical facial pattern

Abstract Aim To compare the effects of the Herbst appliance and the Activator at the completion of two-phase treatment, with respect to the vertical facial pattern (VFP) and to identify possible predictors of treatment effect. Materials and methods Pretreatment, post-treatment and overall cephalometric change data were used to assess the dental and skeletal effects. Results for the change in mandibular length were also compared with changes reported for an untreated external control group. Results Clinically significant dental and skeletal changes (including mandibular incisor proclination and overjet reduction) were characteristics of both treatment methods. Any increases in mandibular length and chin prominence were not greater than those expected following natural growth. The pretreatment VFP remained essentially unaltered, while mean changes as a result of treatment were similar for brachyfacial, mesofacial, and dolichofacial subjects. No predictive factors were identified. Conclusions Clinicians are advised to expect significant overjet reduction and mandibular incisor proclination with either treatment method. Significant skeletal change may be observed in growing subjects; however, any increase in mandibular length or chin projection is not likely to be beyond the limit set by nature. While there will be some individual variation, no significant long-term alteration in the pretreatment vertical facial pattern should be expected with either treatment. Long faces will remain long and short faces will remain short.
Functional Incompatibility between the Generic NF-κB Motif and a Subtype-Specific Sp1III Element Drives the Formation of the HIV-1 Subtype C Viral Promoter

ABSTRACT Of the various genetic subtypes of human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2) and simian immunodeficiency virus (SIV), only in subtype C of HIV-1 is a genetically variant NF-κB binding site found at the core of the viral promoter in association with a subtype-specific Sp1III motif. How the subtype-associated variations in the core transcription factor binding sites (TFBS) influence gene expression from the viral promoter has not been examined previously. Using panels of infectious viral molecular clones, we demonstrate that subtype-specific NF-κB and Sp1III motifs have evolved for optimal gene expression, and neither of the motifs can be replaced by a corresponding TFBS variant. The variant NF-κB motif binds NF-κB with an affinity 2-fold higher than that of the generic NF-κB site. Importantly, in the context of an infectious virus, the subtype-specific Sp1III motif demonstrates a profound loss of function in association with the generic NF-κB motif. An additional substitution of the Sp1III motif fully restores viral replication, suggesting that the subtype C-specific Sp1III has evolved to function with the variant, but not generic, NF-κB motif. A change of only two base pairs in the central NF-κB motif completely suppresses viral transcription from the provirus and converts the promoter into heterochromatin refractory to tumor necrosis factor alpha (TNF-α) induction. The present work represents the first demonstration of functional incompatibility between an otherwise functional NF-κB motif and a unique Sp1 site in the context of an HIV-1 promoter. Our work provides important leads as to the evolution of the HIV-1 subtype C viral promoter with relevance for gene expression regulation and viral latency. IMPORTANCE Subtype-specific genetic variations provide a powerful tool to examine how these variations offer a replication advantage to specific viral subtypes, if any. Only in subtype C of HIV-1 are two genetically distinct transcription factor binding sites positioned at the most critical location of the viral promoter. Since a single promoter regulates viral gene expression, the promoter variations can play a critical role in determining the replication fitness of the viral strains. Our work for the first time provides a scientific explanation for the presence of a unique NF-κB binding motif in subtype C, a major HIV-1 genetic family responsible for half of the global HIV-1 infections. The results offer compelling evidence that the subtype C viral promoter not only is stronger but also is endowed with a qualitative gain-of-function advantage. The genetically variant NF-κB and the Sp1III motifs may be respond differently to specific cell signal pathways, and these mechanisms must be examined.
The effect of spiral arm passages on the evolution of stellar clusters

We study the effect of spiral arm passages on the evolution of star clusters on planar and circular orbits around the centres of galaxies. Individual passages with different relative velocity (V_drift) and arm width are studied using N-body simulations. When the ratio of the time it takes the cluster to cross the density wave to the crossing time of stars in the cluster is much smaller than one, the energy gain of stars can be predicted accurately in the impulsive approximation. When this ratio is much larger than one, the cluster is heated adiabatically and the net effect of heating is largely damped. For a given duration of the perturbation, this ratio is smaller for stars in the outer parts of the cluster compared to stars in the inner part. The cluster energy gain due to perturbations of various duration as obtained from our N-body simulations is in good agreement with theoretical predictions taking into account the effect of adiabatic damping. Perturbations by the broad stellar component of the spiral arms on a cluster are in the adiabatic regime and, therefore, hardly contribute to the energy gain and mass loss of the cluster. We consider the effect of crossings through the high density shocked gas in the spiral arms, which result in a more impulsive compression of the cluster. The time scale of disruption is shortest at ~0.8-0.9 R_CR since there V_drift is low. This location can be applicable to the solar neighbourhood. In addition, the four-armed spiral pattern of the Milky Way makes spiral arms contribute more to the disruption of clusters than in a similar but two-armed galaxy. Still, the disruption time due to spiral arm perturbations there is about an order of magnitude higher than what is observed for the solar neighbourhood. [ABRIDGED]