Miracle-dz/UniFAR-FTUs huggingface dataset:
An interocular comparison of the multifocal VEP: a possible technique for detecting local damage to the optic nerve.

PURPOSE To develop a quantitative measure of local damage to the ganglion cells/optic nerve based on an interocular comparison of multifocal visual evoked potentials (mVEP). METHODS Multifocal VEPs were recorded from both eyes of six normal subjects and four patients; each eye was stimulated separately. Two of the patients had glaucoma, one had ischemic optic neuropathy, and one had unilateral optic neuritis. All four patients had considerably more damage in one eye than in the other, as indicated by their Humphrey visual fields. The multi-input procedure of Sutter was used to obtain 60 VEP responses to a scaled checkerboard pattern. The amplitude in each response was obtained using a root mean square measure of response magnitude. For each of the 60 pairs of responses, a ratio between the amplitude of the responses from the two eyes was obtained as a measure of the relative health of one eye compared with the other. The mean and SD of this ratio measure for the control group were used to specify confidence intervals for each of the 60 locations. All patients had Humphrey 24-2 visual fields performed. To allow a comparison of the mVEPs to the visual fields, a procedure was developed for displaying the results of both tests on a common set of coordinates. RESULTS Except for a small interocular difference in timing attributable to nasotemporal retinal differences, the pairs of mVEP responses from the two eyes of the control subjects were essentially identical. Many of the pairs of responses from the patients were significantly different. In general, there was reasonably good agreement with the Humphrey 24-2 visual field data. Although some regions with visual field defects were not detected in the mVEP due to small responses from the better eye, other abnormalities were detected that were hard to discern in the visual fields. CONCLUSIONS Local monocular damage to the ganglion cell/optic nerve can be quantitatively measured by an interocular comparison of the mVEP.
A Novel WRKY Transcription Factor, SUSIBA2, Participates in Sugar Signaling in Barley by Binding to the Sugar-Responsive Elements of the iso1 Promoter Online version contains Web-only data. Article, publication date, and citation information can be found at www.plantcell.org/cgi/doi/10.1105/tpc.0145

SURE (sugar responsive) is a cis element in plant sugar signaling. The SURE element was reported first for potato, in which it confers sugar responsiveness to the patatin promoter. A SURE binding transcription factor has not been isolated. We have isolated a transcription factor cDNA from barley and purified the corresponding protein. The transcription factor, SUSIBA2 (sugar signaling in barley), belongs to the WRKY proteins and was shown to bind to SURE and W-box elements but not to the SP8a element in the iso1 promoter. Nuclear localization of SUSIBA2 was demonstrated in a transient assay system with a SUSIBA2:green fluorescent protein fusion protein. Exploiting the novel transcription factor oligodeoxynucleotide decoy strategy with transformed barley endosperm provided experimental evidence for the importance of the SURE elements in iso1 transcription. Antibodies against SUSIBA2 were produced, and the expression pattern for susiba2 was determined at the RNA and protein levels. It was found that susiba2 is expressed in endosperm but not in leaves. Transcription of susiba2 is sugar inducible, and ectopic susiba2 expression was obtained in sugar-treated leaves. Likewise, binding to SURE elements was observed for nuclear extracts from sugar-treated but not from control barley leaves. The temporal expression of susiba2 in barley endosperm followed that of iso1 and endogenous sucrose levels, with a peak at ∼12 days after pollination. Our data indicate that SUSIBA2 binds to the SURE elements in the barley iso1 promoter as an activator. Furthermore, they show that SUSIBA2 is a regulatory transcription factor in starch synthesis and demonstrate the involvement of a WRKY protein in carbohydrate anabolism. Orthologs to SUSIBA2 were isolated from rice and wheat endosperm.
Peripheral Nerve Field Stimulation for Intractable Post‐Thoracotomy Scar Pain not Relieved by Conventional Treatment

Peripheral nerve field stimulation (PNFS) is being applied in individual cases where conventional treatments have failed to control pain localized to limited dermatomal distribution. We applied PNFS for unrelieved post‐thoracotomy scar pain. Although spinal cord stimulation may have resulted in good coverage in the same dermatomal distribution, we chose the more peripheral approach to minimize the risk of complications, avoiding the potential neurologic sequelae associated with stimulation of the spinal cord. In summary, PNFS was effective in relieving post‐thoractomy pain refractory to conventional pain management suggesting great potential of PNFS as a treatment option for chronic surgical‐scar pain.
Explicit recognition of emotional facial expressions is shaped by expertise: evidence from professional actors

Can reading others' emotional states be shaped by expertise? We assessed processing of emotional facial expressions in professional actors trained either to voluntary activate mimicry to reproduce character's emotions (as foreseen by the “Mimic Method”), or to infer others' inner states from reading the emotional context (as foreseen by “Stanislavski Method”). In explicit recognition of facial expressions (Experiment 1), the two experimental groups differed from each other and from a control group with no acting experience: the Mimic group was more accurate, whereas the Stanislavski group was slower. Neither acting experience, instead, influenced implicit processing of emotional faces (Experiment 2). We argue that expertise can selectively influence explicit recognition of others' facial expressions, depending on the kind of “emotional expertise”.
SRA Regulates Adipogenesis by Modulating p38/JNK Phosphorylation and Stimulating Insulin Receptor Gene Expression and Downstream Signaling

The Steroid Receptor RNA Activator (SRA) enhances adipogenesis and increases both glucose uptake and phosphorylation of Akt and FOXO1 in response to insulin. To assess the mechanism, we differentiated ST2 mesenchymal precursor cells that did or did not overexpress SRA into adipocytes using combinations of methylisobutylxanthine, dexamethasone and insulin. These studies showed that SRA overexpression promotes full adipogenesis in part by stimulation of insulin/insulin-like growth factor-1 (IGF-1) signaling. SRA overexpression inhibited phosphorylation of p38 mitogen activated protein kinase (MAPK) and c-Jun NH2-terminal kinase (JNK) in the early differentiation of ST2 cells. Conversely, knockdown of endogenous SRA in 3T3-L1 cells increased phosphorylation of JNK. Knockdown of SRA in mature 3T3-L1 adipocytes reduced insulin receptor (IR) mRNA and protein levels, which led to decreased autophosphorylation of IRβ and decreased phosphorylation of insulin receptor substrate-1 (IRS-1) and Akt. This likely reflects a stimulatory role of SRA on IR transcription, as transfection studies showed that SRA increased expression of an IR promoter-luciferase reporter construct.
Modeling Aboveground Biomass in Tropical Forests Using Multi-Frequency SAR Data—A Comparison of Methods

In the context of climate change mitigation mechanisms for avoiding deforestation, i.e., reducing emissions from deforestation and forest degradation (REDD+), comprehensive forest monitoring, especially in tropical regions, is of high relevance. A precise determination of forest carbon stocks or aboveground biomass (AGB) for large areas is of special importance.
Effect of ethylene and carbon dioxide on potato metabolism: stimulation of tuber and mitochondrial respiration, and inducement of the alternative path.

The respiration of potato tubers (Solanum tuberosum var. Russet Burbank) which have been kept at room temperature for 10 days is stimulated upon subsequent treatment with C(2)H(4) (10 microliters per liter) and O(2). The respiratory rise reaches a peak in 24 to 30 hours and thereafter declines. Coincident with the rise in tuber respiration is an increase in the respiratory rates of fresh slices and isolated mitochondria. Slices and mitochondria from C(2)H(4)- and O(2)-treated tubers also display substantial resistance to CN, and the resistant respiration is inhibited by hydroxamates.The longer the tubers are stored after harvest, the less effective is C(2)H(4) in causing CN resistance in slices and mitochondria from treated tubers. Addition of 10% CO(2) to the C(2)H(4)-O(2) mixture, however, causes extensive CN resistance to develop, even in slices and mitochondria from old tubers. The results show that C(2)H(4), O(2), and CO(2) act synergistically to induce alternative path development in potatoes.
Posaconazole and Amphotericin B Combination Therapy against Cryptococcus neoformans Infection

ABSTRACT To investigate the effects of posaconazole (POS) and amphotericin B (AMB) combination therapy in cryptococcal infection, we established an experimental model of systemic cryptococcosis in CD1 mice by intravenous injection of three distinct clinical isolates of Cryptococcus neoformans. Therapy was started 24 h after the infection and continued for 10 consecutive days. POS was given at 3 and 10 mg/kg of body weight/day, while AMB was given at 0.3 mg/kg/day. Combination therapy consisted of POS given at a low (combo 3) or at a high (combo 10) dose plus AMB. Survival studies showed that combo 3 was significantly more effective than POS at 3 mg/kg for two isolates tested (P value, ≤0.001), while combo 10 was significantly more effective than POS at 10 mg/kg for all three isolates (P values ranging from <0.001 to 0.005). However, neither combination regimen was more effective than AMB alone. For two isolates, combination therapy was significantly more effective than each single drug at reducing the fungal burden in the brain (P values ranging from 0.001 to 0.015) but not in the lungs. This study demonstrates that the major impact of POS and AMB combination therapy is on brain fungal burden rather than on survival.
Accuracy and Reliability of Anterior Cruciate Ligament Clinical Examination in a Multidisciplinary Sports Medicine Setting

Objective: To investigate the accuracy and reliability of anterior cruciate ligament (ACL) clinical examination in a multidisciplinary sports medicine setting. Design: Retrospective review of patient charting. Setting: Community-based multidisciplinary sports medicine clinic. Patients: One hundred twelve patients with surgically confirmed ACL tear. Interventions: Review of therapist, physician, and orthopedic surgeon charting. Main Outcome Measures: Scoring for the anterior drawer, Lachman, and pivot shift tests completed during clinical examination. Coefficient of agreement (Po) was calculated for each assessment technique to determine the interrater reliability. Sensitivity of assessment was determined by comparing patient's arthroscopic surgical results against clinician's scoring. Results: On average, Po values indicated only moderate levels of interrater reliability (anterior drawer, &OV0335; = 0.57; Lachman, &OV0335; = 0.45; pivot shift, &OV0335; = 0.53), with great variation observed between clinician's scoring for each assessment technique. Accuracy testing demonstrated that the Lachman test had the highest level of sensitivity when administered by orthopedic surgeons (&OV0335; = 86%) and that sensitivity varied greatly among clinician groups and by assessment technique (range, 15%-87%). Conclusions: In sports medicine, unreliable or inaccurate clinical examination confounds the clinician's ability to make informed decisions regarding appropriate patient referral and treatment interventions. Our results indicate that levels of accuracy and reliability for clinical examination of the ACL within a multidisciplinary sports medicine setting may be much lower than previously reported within the literature. Further research is needed to clarify whether a standardized approach to ACL clinical examination could enhance levels of accuracy and reliability among clinicians working in a multidisciplinary setting.
Bounds on Separating Redundancy of Linear Codes and Rates of X-Codes

An error-erasure channel is a simple noise model that introduces both errors and erasures. While the two types of errors can be corrected simultaneously with error-correcting codes, it is also known that any linear code allows for first correcting errors and then erasures in two-step decoding. In particular, a carefully designed parity-check matrix not only allows for separating erasures from errors but also makes it possible to efficiently correct erasures. The separating redundancy of a linear code is the number of parity-check equations in a smallest parity-check matrix that has the required property for this error-erasure separation. In a sense, it is a parameter of a linear code that represents the minimum overhead for efficiently separating erasures from errors. While several bounds on separating redundancy are known, there still remains a wide gap between upper and lower bounds except for a few limited cases. In this paper, using probabilistic combinatorics and design theory, we improve both upper and lower bounds on separating redundancy. We also show a relation between parity-check matrices for error-erasure separation and special matrices, called X-codes, for data compaction circuits in VLSI testing. This leads to an exponentially improved bound on the size of an optimal X-code.
A Cognitive Distortions and Deficits Model of Suicide Ideation

Although cognitive distortions and deficits are known risk factors for the development and escalation of suicide ideation and behaviour, no empirical work has examined how these variables interact to predict suicide ideation. The current study proposes an integrative model of cognitive distortions (hopelessness and negative evaluations of self and future) and deficits (problem solving deficits, problem solving avoidance, and cognitive rigidity). To test the integrity of this model, a sample of 397 undergraduate students completed measures of deficits, distortions, and current suicide ideation. A structural equation model demonstrated excellent fit, and findings indicated that only distortions have a direct effect on suicidal thinking, whereas cognitive deficits may exert their effects on suicide ideation via their reciprocal relation with distortions. Findings underscore the importance of both cognitive distortions and deficits for understanding suicidality, which may have implications for preventative efforts and treatment.
Microstructure, mechanical properties, and fracture behavior of liquid rubber toughened thermosets

Phenolic epoxy resin was toughened by carboxyl-randomized butadiene acrylonitrile copolymer (CRBN) for use as composite matrix. By adding different parts of butadiene acrylonitrile copolymer (BN-26, without carboxyl contained) to CRBN, different sizes of rubber domains and different numbers of chemical bondings between the resin matrix and the rubber phase were obtained. It is found that small rubber particles (less than 0.1 μm) are cavitated during the crack development. The interaction between secondary crack zones caused by the cavitation makes the fracture toughness KIC of the materials high; by comparison, a local stress-whitened zone is produced in the material with large rubber particles (more than 0.1 μm) when it is subjected to tensile stress. In this case, the flexure strength σf of the material is great. Using ultrasection and TEM techniques, the stress-whitened zone was shown to be caused by the special multiple-phase structure of the material, in which many caves and “macrocrazes” coexist.
Spatial Distribution of Orofacial Cleft Defect Births in Harris County, Texas, 1990 to 1994, and Historical Evidence for the Presence of Low-level Radioactivity in Tap Water

Background: While both ionizing and nonionizing radiation are known to impair human reproductive capacity, the role of low-level domestic radiation continues to be an unsettled issue. Objectives: We examined the geostatistical distribution (residential longitude and latitude) of orofacial cleft birth cases adjusted for the underlying population distribution. Furthermore, we examined the cleft birth rates enumerated by zip codes for possible associations with levels of radium and radon in drinking water. Methods: Cleft births and unaffected live births in Harris County, Texas, from 1990 to 1994, were geocoded by residential addresses and tested for spatial clusters using the space-time clustering program SaTScan. Historical sample data on local variations in water quality facilitated the assessment of the association of orofacial cleft defect births with low-level radiation exposure. Results: A cluster of significantly greater than expected numbers of cleft defect births was identified in northwest Harris County, (relative risk = 3.0, P = 0.043), where the presence of elevated levels of radium (>3 pCi/L) and radon (>300 pCi/L) in the tap water has been known since the 1980s. Conclusions: Despite the ecological design of the study, lacking individual exposure measurements for cleft birth residences, there was strong suggestive evidence of an association between elevated radiation levels in tap water and elevated cleft birth prevalence rates by zip codes. Attention of physicians is invited to environmental causes as potential risk factors for orofacial cleft. This would aid in genetic counseling and the development of future preventive measures.
Efficient dynamic programming using quadrangle inequalities

<italic>Dynamic programming</italic> is one of several widely used problem-solving techniques in computer science and operation research. In applying this technique, one always seeks to find speed-up by taking advantage of special properties of the problem at hand. However, in the current state of art, ad hoc approaches for speeding up seem to be characteristic; few general criteria are known. In this paper we give a <italic>quadrangle inequality</italic> condition for rendering speed-up. This condition is easily checked, and can be applied to several apparently different problems. For example, it follows immediately from our general condition that the construction of optimal binary search trees may be speeded up from <italic>O(n</italic><supscrpt>3</supscrpt>) steps to <italic>O(n</italic><supscrpt>2</supscrpt>), a result that was first obtained by Knuth using a different and rather complicated argument.
Effect of Sucrose on the Selection of Mutans Streptococci and Lactobacilli in Dental Biofilm Formedin situ

Microorganisms are selected in dental biofilm by the acidic environment created by sugar fermentation, but the effect of extracellular polysaccharide (EPS) on the counts of cariogenic bacteria is not clear. Dental biofilm was formed in situ for 13 days under exposure 8 times a day to distilled-deionized water, glucose + fructose or sucrose solutions. Mutans streptococci (MS) counts were not different among the groups, but lactobacilli (LB) were significantly higher in glucose + fructose and sucrose groups, without significant difference between them, irrespective of the higher insoluble EPS concentration in the sucrose biofilm matrix. The data suggest that exposure to sugar is more relevant for the predominance of LB in dental biofilm than for MS and that insoluble EPS does not change the counts of these microorganisms in the biofilm.
Effect of Moringa oleifera leaf powder on sperm count, histology of testis and epididymis of hyperglycaemic mice Mus musculus

The aim of the study is to evaluate the effect of leaf powder of Moringa oleifera Lam. on male reproductive system of Swiss albino mice Mus musculus. The sperm count, its mobility and mortality, histology of testis and epididymis of normal and hyperglycaemic male Swiss albino mice have been investigated and attempt has been taken to evaluate the efficacy of Moringa leaf powder in repair mechanism in case of hyperglycaemia. Three sets of animal, i.e. Control (Group I), Hyperglycaemic (Group II) and Hyperglycaemic fed with Moringa powder (Group III) were taken for the experiment. Both normal and hyperglycaemic mice were fed with 200mg/ kg body weight of Moringa leaf powder. The sperm count (million /mm 3) recorded decrease in hyperglycaemic mice (Group II) as compared to control (Group I) but improved in treated mice(Group III), the mobility of sperm also decreased in hyperglycaemic mice but mortality increased in hyperglycaemic mice. In treated mice (Group III), the sperm count significantly increased, sperm mobility also increased but sperm mortality decreased significantly. There was a slight decrease in weight of testis (0.478±0.008gm to 0.33±0.006 gram) respectively when compared to control mice. The value improved after supplementation of Moringa oleifera leaf powder (0.33±0.006 gm to 0.415±0.005gm). Similar trend was recorded for Epididymal weight i.e. slight decrease in the weight of epididymis of diabetic mice (from 0.1444±0.003 gm to 0.0521±0.004) and a gradual increase was noticed in the weight from 0.00521±0.004gm to 0.1055±0.001gm) after 21 days treatment.
Endotoxin exposure and changes in short-term pulmonary function among sewage workers.

OBJECTIVES The inhaled endotoxin is considered as a causative factor in the process of acute bronchial obstruction, which can be measured by a decrease in forced expiratory volume in 1 s (FEV1). The aim of this study was to assess endotoxin exposure among sewage treatment plant workers (STPW) and its effect on across-shift changes in respiratory airflow. MATERIAL AND METHODS A group of 78 STPW from a large sewage treatment plant was studied. Inhalable dust for endotoxin assessment was collected using personal aerosol samplers. Endotoxin was assayed with the kinetic, chromogenic Limulus amebocyte lysate test. Across-shift spirometric measurements were performed on Mondays, after 2-days absence from work, with the use of portable spirometer. The forced vital capacity (FVC), and FEV1 parameters were analyzed. Multifactor regression modeling was performed to determine parameters significantly associated with endotoxin exposure. RESULTS The concentration of inhalable dust and endotoxin ranged from 0.01-1.38 mg/m3 and 0.68-214 endotoxin units per cubic meter of air (EU/m3), respectively. Endotoxins were characterized with the skewed distribution (arithmetic mean (AM) = 38.8 EU/m3, geometric mean (GM) = 15.4 EU/m3, geometric standard deviation (GSD) = 4.21). Through the use of multifactor analysis, which excluded the main confounders (inhalable dust and smoking habit) it was found that, despite low levels of endotoxin, it had significant impact on the observed across-shift decline in FEV1 (p = 0.044). For this parameter, the regression slope was additionally calculated (r = -0.017, p = 0.071). CONCLUSIONS Relatively low levels of endotoxin among sewage treatment plant workers may cause small, but significant across-shift declines in FEV1. The observed relationship was independent of organic dust concentrations and smoking habit. The respiratory protection should be provided for STPW.