Miracle-dz/UniFAR-FTUs huggingface dataset:
Computer Based Testing (CBT): An Assessment of Student Perception of JAMB UTME in Nigeria

In Nigeria students are assessed using paper and pen on cognitive abilities. This method of assessment is however, characterized by different forms of examination malpractices. The threat of examination malpractices on the validity of examination outcomes has resulted in some examination bodies adopting a different method of administration. One of such is the Joint Admissions and Matriculation Board (JAMB) that has introduced Computer Based Testing (CBT) in the conduct of Unified Tertiary Matriculation Examination (UTME). Using survey research method, this study investigated the perception of student on the use of computer based testing in examinations. Problems encountered by the student and prospective methods of enhancing CBT acceptance in Nigeria were also documented. A total of 300 questionnaires were administered to students who participated in the 2014 UTME at Ahmadu Bello University (ABU), Zaria center and 237 were adequately completed and found usable representing (79%). The finding revealed among others, that majority of the respondents confirmed that CBT can curb examination malpractice. Majority of candidates were also found to prefer CBT than the conventional way of writing examination. The Chisquare and Pearson’s correlation analysis showed that the respondents preferences for CBT was sensitive across gender, age distribution and student faculty. While improving electricity supply was identified as critical in enhancing CBT Exams, poor ICT skill on the part of student and the invigilators were identified as the major problem facing the implementation of JAMB CBT Exam. The paper recommends the need for JAMB to create more awareness on CBT inorder to enhance JAMB CBT examination in Nigeria.
Protective effect of Pongamia pinnata flowers against cisplatin and gentamicin induced nephrotoxicity in rats.

Ethanolic extract of flowers of Pongamia pinnata was studied for its protective effect against cisplatin and gentamicin induced renal injury in rats. When the extract (300 & 600 mg kg(-1)) was administered orally for 10 days following cisplatin (5 mg kg(-1) i.p.) on day 5, toxicity of cisplatin, as measured by loss of body weight, elevated blood urea and serum creatinine declined significantly. Similarly in gentamicin (40 mg kg(-1) s.c. ) induced renal injury, the extract (600 mg kg(-1)) normalized the raised blood urea and serum creatinine levels. Reversal of cisplatin and gentamicin renal cell damage as induced by tubular necrosis ie, marked congestion of the glomeruli with glomerular atrophy, degeneration of tubular epithelial cells with casts in the tubular lumen and infiltration of inflammatory cells in the interstitium was confirmed on histopathological examination. In the preventive regimen, co-administration of the extract with gentamicin significantly prevented the renal injury both functionally and histologically. Ethanolic extract of flowers had a marked nitric oxide free radical scavenging effect, suggesting an antioxidative property. Two flavonoids, known for their antioxidant activity viz. kaempferol and 3, 5, 6, 7, 8-pentamethoxy flavone were isolated from the extract. The results suggested that the flowers of Pongamia pinnata had a protective effect against cisplatin and gentamicin induced renal injury through antioxidant property.
Fourier expansions and integral representations for the Apostol-Bernoulli and Apostol-Euler polynomials

We investigate Fourier expansions for the Apostol-Bernoulli and Apostol-Euler polynomials using the Lipschitz summation formula and obtain their integral representations. We give some explicit formulas at rational arguments for these polynomials in terms of the Hurwitz zeta function. We also derive the integral representations for the classical Bernoulli and Euler polynomials and related known results.
Using Genetic Algorithms to Explore Pattern Recognition in the Immune System

This paper describes an immune system model based on binary strings. The purpose of the model is to study the pattern-recognition processes and learning that take place at both the individual and species levels in the immune system. The genetic algorithm (GA) is a central component of the model. The paper reports simulation experiments on two pattern-recognition problems that are relevant to natural immune systems. Finally, it reviews the relation between the model and explicit fitness-sharing techniques for genetic algorithms, showing that the immune system model implements a form of implicit fitness sharing.
Tigecycline and intravenous fosfomycin zone breakpoints equivalent to the EUCAST MIC criteria for Enterobacteriaceae.

INTRODUCTION Tigecycline and intravenous (i.v.) fosfomycin could be alternative therapeutic options for the treatment of carbapenemase-possessing Enterobacteriaceae bacterial infections. However, routine laboratories are forced to test these drugs using minimum inhibitory concentration (MIC) methods as zone breakpoints are not available for the disc diffusion technique. METHODOLOGY Clinical and Laboratory Standards Institute methods for agar dilution and disc diffusion were compared to determine tentative zone breakpoints that best correlate to tigecycline and i.v. fosfomycin MIC breakpoints defined by the European Committee on Antimicrobial Susceptibility Testing. A total of 195 Enterobacteriaceae with defined mechanisms of resistance were tested in duplicate assays. Half of the strains were characterized as carbapenemase producers (KPC-2, OXA-48, OXA-163, VIM-1, VIM-2, IMP-8, NDM-1). RESULTS Corresponding zone diameters of susceptible ≥ 15 mm, resistant ≤ 12mm and susceptible ≥ 17 mm, resistant ≤ 15 mm for the 50 µg fosfomycin plus 50 µg glucose-6-phosphate and 200 µg fosfomycin plus 50 µg glucose-6-phosphate discs, respectively, allowed categorization of the strains with an acceptable level of error (< 10% minor errors, < 1.5 % major errors, < 1% very major errors and categorical agreement > 90%). For the 15 µg tigecycline disc, the best performance was achieved with the corresponding zone diameters of susceptible ≥ 21 mm and resistant ≤ 16 mm, which eliminated the very major and major errors but not the minor errors (34.4%). CONCLUSIONS Based on these results, tigecycline and fosfomycin can be included in the routine panel of antibiotics for susceptibility testing by disc diffusion to provide fast and reliable information for the selection of treatment alternatives, especially for strains with extreme resistance, as carbapenemase producers.
How Do Astronomers Share Data? Reliability and Persistence of Datasets Linked in AAS Publications and a Qualitative Study of Data Practices among US Astronomers

We analyze data sharing practices of astronomers over the past fifteen years. An analysis of URL links embedded in papers published by the American Astronomical Society reveals that the total number of links included in the literature rose dramatically from 1997 until 2005, when it leveled off at around 1500 per year. The analysis also shows that the availability of linked material decays with time: in 2011, 44% of links published a decade earlier, in 2001, were broken. A rough analysis of link types reveals that links to data hosted on astronomers' personal websites become unreachable much faster than links to datasets on curated institutional sites. To gauge astronomers' current data sharing practices and preferences further, we performed in-depth interviews with 12 scientists and online surveys with 173 scientists, all at a large astrophysical research institute in the United States: the Harvard-Smithsonian Center for Astrophysics, in Cambridge, MA. Both the in-depth interviews and the online survey indicate that, in principle, there is no philosophical objection to data-sharing among astronomers at this institution. Key reasons that more data are not presently shared more efficiently in astronomy include: the difficulty of sharing large data sets; over reliance on non-robust, non-reproducible mechanisms for sharing data (e.g. emailing it); unfamiliarity with options that make data-sharing easier (faster) and/or more robust; and, lastly, a sense that other researchers would not want the data to be shared. We conclude with a short discussion of a new effort to implement an easy-to-use, robust, system for data sharing in astronomy, at theastrodata.org, and we analyze the uptake of that system to-date.
Early endoscopic, laboratory and clinical predictors of poor disease course in paediatric ulcerative colitis

Objective Data to support treatment algorithms in ambulatory paediatric UC are scarce. We aimed to explore the 1 year outcome in an inception cohort of paediatric UC patients and to identify early predictors of good outcome that might serve as short term treatment targets. Design A chart review of 115 children with new onset UC was performed (age 11±4.1 years; 58 (50%) males; 86 (75%) extensive colitis; 70 (61%) moderate–severe disease; 63 (55%) received steroids at baseline). We assessed the Paediatric Ulcerative Colitis Activity Index (PUCAI) and laboratory variables at the time of diagnosis and at 3 months, and endoscopy at diagnosis. Results The 3 month PUCAI was the strongest predictor of 1 year sustained steroid free remission (SSFR) (area under the receiver operating characteristic curve (AUROC)=0.7 (95% CI 0.6 to 0.8) and colectomy by 2 years (AUROC=0.75 (0.6 to 0.89)). SSFR was achieved in 9/54 (17%) children who had active disease (PUCAI ≥10) at 3 months (negative predictive value (NPV)=83%) and by 4/46 (8.6%) of those with a PUCAI score >10; (NPV=91%, positive predictive value=52%; p<0.001), implying that PUCAI >10 at 3 months has a probability of 9% for achieving SSFR versus 48% with a PUCAI value of ≤10. None of the variables at baseline was predictive of SSFR or colectomy (endoscopic severity, disease extent, age, PUCAI or C reactive protein/erythrocyte sedimentation rate/albumin/haemoglobin; all AUROC<0.6, p>0.05) but baseline PUCAI predicted subsequent acute severe colitis and the need for salvage medical therapy. Conclusions Completeness of the early response appears more important than baseline UC severity for predicting outcome in children, and supports using PUCAI<10 as a feasible treatment goal. Our data suggest that treatment escalation should be considered with a PUCAI value of ≥10 at 3 months.
Positron emission tomography studies on the dopaminergic system and striatal opioid binding in the olivopontocerebellar atrophy variant of multiple system atrophy

Ten patients with sporadic olivopontocerebellar atrophy and autonomic failure were studied with positron emission tomography. Subjects underwent both an {11C}diprenorphine and an {18F}fluorodopa scan. The mean caudateoccipital uptake ratio for {11C}diprenorphine was significantly reduced to 88% and the putamen‐occipital uptake ratio to 85% of the control values. Individually, 4 of the 10 patients had significantly reduced opioid binding in the putamen. Mean putamen {18F}fluorodopa uptake was significantly diminished (to 71% of the control mean); individually 7 patients had significantly reduced uptake. There was a significant positive correlation between putamen‐occipital uptake ratios for {11C}diprenorphine and putamen uptake of {18F}fluorodopa. Our results suggest that subclinical nigrostriatal dysfunction is present in the majority of patients with sporadic olivopontocerebellar atrophy, in accordance with it being part of the spectrum of multiple system atrophy.
Silencing the Morphogenesis of Rotavirus

ABSTRACT The morphogenesis of rotaviruses follows a unique pathway in which immature double-layered particles (DLPs) assembled in the cytoplasm bud across the membrane of the endoplasmic reticulum (ER), acquiring during this process a transient lipid membrane which is modified with the ER resident viral glycoproteins NSP4 and VP7; these enveloped particles also contain VP4. As the particles move towards the interior of the ER cisternae, the transient lipid membrane and the nonstructural protein NSP4 are lost, while the virus surface proteins VP4 and VP7 rearrange to form the outermost virus protein layer, yielding mature infectious triple-layered particles (TLPs). In this work, we have characterized the role of NSP4 and VP7 in rotavirus morphogenesis by silencing the expression of both glycoproteins through RNA interference. Silencing the expression of either NSP4 or VP7 reduced the yield of viral progeny by 75 to 80%, although the underlying mechanism of this reduction was different in each case. Blocking the synthesis of NSP4 affected the intracellular accumulation and the cellular distribution of several viral proteins, and little or no virus particles (neither DLPs nor TLPs) were assembled. VP7 silencing, in contrast, did not affect the expression or distribution of other viral proteins, but in its absence, enveloped particles accumulated within the lumen of the ER, and no mature infectious virus was produced. Altogether, these results indicate that during a viral infection, NSP4 serves as a receptor for DLPs on the ER membrane and drives the budding of these particles into the ER lumen, while VP7 is required for removing the lipid envelope during the final step of virus morphogenesis.
Association of thymidylate synthase variants with 5-fluorouracil cytotoxicity

Identifying relevant cytotoxicity genes using an ex-vivo lymphoblastoid cell line (LCLs) model has distinct advantages for pharmacogenomic discovery studies of cancer chemotherapy, including standardized treatment conditions, availability of large numbers of samples, and publicly available genotypic data. However, there is little proof of principal data to confirm the promise of this approach. One of the known targets of 5-fluorouracil (5-FU) treatment is thymidylate synthase (TYMS). We hypothesized that genetic variants in TYMS would alter cytotoxicity because of 5-FU treatment using a LCL model system. LCLs from the Centre d'Etude du Polymorphisme Humain (CEPH) pedigrees (N=427) were treated with eight concentrations of 5-FU for 72 h, and cytotoxicity was determined using an Alamar Blue assay. For a subset of the 30 International Haplotype Mapping project (HapMap) trios, genotype data for 46 single-nucleotide polymorphism (SNP) variants encompassing the TYMS gene were downloaded from the HapMap website. Using a mixed models approach, each SNP was tested for association to 5-FU cytotoxicity in the subset of HapMap trios. Putatively associated SNPs (P<0.01), were then genotyped in the remaining LCLs in the CEPH pedigrees and tested for association. Two intronic SNPs in TYMS (rs2847153 and rs2853533) were significantly associated (P<0.01) with 5-FU cytotoxicity in the HapMap subset using the mixed models approach. After genotyping these SNPs in the full CEPH pedigrees, the associations with cytotoxicity showed a more reliable significance (P<0.0005), as a result of the increase in sample size. These results highlight the importance of the TYMS gene variants in response to 5-FU treatment. Furthermore, they provide additional biological validation of the relevance of LCLs as a model for pharmacogenomic gene discovery in cancer chemotherapy.
Reproductive Compatibility of Prairie and Montane Populations of Dermacentor andersoni

Abstract Genetic analysis of prairie and montane populations of Dermacentor andersoni (Stiles) originating from Alberta (AB) and British Columbia (BC), Canada, respectively, indicated limited gene flow (Nm < 1) and a large amount of genetic differentiation (Fst = 0.49) between the populations. The prairie population also had a greater level of genetic diversity. Mating experiments indicated that females of geographically heterogeneous crosses had similar engorgement and oviposition failure as homogenous crosses in the parental generation but that egg mass sterility was greatest for the AB♀ × BC♂ cross, intermediate for the homogenous crosses, and lowest for the BC♀ × AB♂ cross. The progeny of all crosses produced fertile eggs, and the only significant effect in the progeny generation was increased oviposition failure of the pure AB cross. Covariate analysis indicated that egg mass sterility was associated with BC males in the parental generation and that oviposition failure was associated with AB males and AB females in the progeny generation. The hazard of cumulative reproductive failure was increased with AB females in both generations, reduced for AB males in the parental generation, and increased with AB males in the progeny generation. Overall, heterogenous crosses had the greatest and least reproductive failure in the parental generation, but they were intermediate to the homogenous crosses in the progeny generation. The limited gene flow between the populations seems to have been sufficient to maintain reproductive compatibility.
How do company reputation and perceived price influence customer loyalty in the Chinese personal financial planning industry?

To understand the antecedents of customer loyalty from a service marketing perspective is crucial for both practice and academic research. We build and test a causal model based on data from Chinese consumers in the personal financial planning industry. Conducting the data analysis through structural equation modeling, we found that both company reputation and perceived price can enhance perceived value, whereas risk perception exerts negative influence on perceived value. In addition, perceived value directly affects consumer satisfaction and positive word of mouth and indirectly influences switching intention.
The Valuations of the Near Polygon Gn

We show that every valuation of the near $2n$-gon ${\Bbb G}_n$, $n \geq 2$, is induced by a unique classical valuation of the dual polar space $DH(2n-1,4)$ into which ${\Bbb G}_n$ is isometrically embeddable.
Performance improvement of least-recently-used policy in web proxy cache replacement using supervised machine learning

Web proxy caching is one of the most successful solutions for improving the performance of Web-based systems. In Web proxy caching, Least-Recently-Used (LRU) policy is the most common proxy cache replacement policy, which is widely used in Web proxy cache management. However, LRU are not efficient enough and may suffer from cache pollution with unwanted Web objects. Therefore, in this paper, LRU policy is enhanced using popular supervised machine learning techniques such as a support vector machine (SVM), a naive Bayes classifier (NB) and a decision tree (C4.5). SVM, NB and C4.5 are trained from Web proxy logs files to predict the class of objects that would be re-visited. More significantly, the trained SVM, NB and C4.5 classifiers are intelligently incorporated with the traditional LRU algorithm to present three novel intelligent Web proxy caching approaches, namely SVM-LRU, NB-LRU and C4.5-LRU. In the proposed intelligent LRU approaches, unwanted objects classified by machine learning classifier are placed in the middle of the cache stack used, so these objects are efficiently removed at an early stage to make space for new incoming Web objects. The simulation results demonstrated that the average improvement ratios of hit ratio achieved by SVM-LRU, NB-LRU and C4.5-LRU over LRU increased by 30.15%, 32.60% and 31.05 % respectively, while the average improvement ratios of byte hit ratio increased by 32.43%, 69.56% and 28.41%, respectively.
Selected ABCB1, ABCB4 and ABCC2 Polymorphisms Do Not Enhance the Risk of Drug-Induced Hepatotoxicity in a Spanish Cohort

Background and Aims Flawed ABC transporter functions may contribute to increased risk of drug-induced liver injury (DILI). We aimed to analyse the influence of genetic variations in ABC transporters on the risk of DILI development and clinical presentations in a large Spanish DILI cohort. Methods A total of ten polymorphisms in ABCB1 (1236T>C, 2677G>T,A, 3435T>C), ABCB4 (1954A>G) and ABCC2 (−1774G>del, −1549A>G, −24C>T, 1249G>A, 3972C>T and 4544G>A) were genotyped using Taqman 5′ allelic discrimination assays or sequencing in 141 Spanish DILI patients and 161 controls. The influence of specific genotypes, alleles and haplotypes on the risk of DILI development and clinical presentations was analysed. Results None of the individual polymorphisms or haplotypes was found to be associated with DILI development. Carriers homozygous for the ABCC2 −1774del allele were however only found in DILI patients. Hence, this genotype could potentially be associated with increased risk, though its low frequency in our Spanish cohort prevented a final conclusion. Furthermore, carriers homozygous for the ABCC2 −1774G/−1549A/−24T/1249G/3972T/4544G haplotype were found to have a higher propensity for total bilirubin elevations when developing DILI. Conclusions Our findings do not support a role for the analysed polymorphisms in the ABCB1, ABCB4 and ABCC2 transporter genes in DILI development in Spanish patients. The ABCC2 −1774deldel genotype was however restricted to DILI cases and could potentially contribute to enhanced DILI susceptibility.
Neuroimaging during Trance State: A Contribution to the Study of Dissociation

Despite increasing interest in pathological and non-pathological dissociation, few researchers have focused on the spiritual experiences involving dissociative states such as mediumship, in which an individual (the medium) claims to be in communication with, or under the control of, the mind of a deceased person. Our preliminary study investigated psychography – in which allegedly “the spirit writes through the medium's hand” – for potential associations with specific alterations in cerebral activity. We examined ten healthy psychographers – five less expert mediums and five with substantial experience, ranging from 15 to 47 years of automatic writing and 2 to 18 psychographies per month – using single photon emission computed tomography to scan activity as subjects were writing, in both dissociative trance and non-trance states. The complexity of the original written content they produced was analyzed for each individual and for the sample as a whole. The experienced psychographers showed lower levels of activity in the left culmen, left hippocampus, left inferior occipital gyrus, left anterior cingulate, right superior temporal gyrus and right precentral gyrus during psychography compared to their normal (non-trance) writing. The average complexity scores for psychographed content were higher than those for control writing, for both the whole sample and for experienced mediums. The fact that subjects produced complex content in a trance dissociative state suggests they were not merely relaxed, and relaxation seems an unlikely explanation for the underactivation of brain areas specifically related to the cognitive processing being carried out. This finding deserves further investigation both in terms of replication and explanatory hypotheses.
Sweep-tone measurements of vocal-tract characteristics.

The vocal tract was excited transcutaneously at a point just above the glottis by an external sweep‐tone signal, in order to measure its transfer characteristics acoustically as continuous frequency functions. An analysis‐by‐synthesis procedure derived reliable data of vowels, in particular of the formant bandwidths, for three male and three female normal subjects. It has been shown for the closed glottis condition that the first formant bandwidths are higher for close vowels (typically 70 Hz for male subjects) than for semi‐open vowels (typically 35 Hz for male subjects). Stationary consonantal articulations including stops, nasals, and nasalized vowels also have been studied, as well as the effect of opening the glottis on the vocal‐tract transfer characteristics. The stop articulations give rise to a first‐formant frequency slightly below 200 Hz. This fact and the high dissipation of the first formant is explained by assuming nonrigidness of the surrounding wall. Characteristics of nasalized vowels and.