Miracle-dz/UniFAR-FTUs huggingface dataset:
Transcription Profiles of Endothelial Cells in the Rat Ductus Arteriosus during a Perinatal Period

Endothelial cells (ECs) lining the blood vessels serve a variety of functions and play a central role in the homeostasis of the circulatory system. Since the ductus arteriosus (DA) has different arterial characteristics from its connecting vessels, we hypothesized that ECs of the DA exhibited a unique gene profile involved in the regulation of DA-specific morphology and function. Using a fluorescence-activated cell sorter, we isolated ECs from pooled tissues from the DA or the descending aorta of Wistar rat fetuses at full-term of gestation (F group) or neonates 30 minutes after birth (N group). Using anti-CD31 and anti-CD45 antibodies as cell surface markers for ECs and hematopoietic derived cells, respectively, cDNAs from the CD31-positive and CD45-negative cells were hybridized to the Affymetrix GeneChip® Rat Gene 1.0 ST Array. Among 26,469 gene-level probe sets, 82 genes in the F group and 81 genes in the N group were expressed at higher levels in DA ECs than in aortic ECs (p<0.05, fold change>2.0). In addition to well-known endothelium-enriched genes such as Tgfb2 and Vegfa, novel DA endothelium-dominant genes including Slc38a1, Capn6, and Lrat were discovered. Enrichment analysis using GeneGo MetaCore software showed that DA endothelium-related biological processes were involved in morphogenesis and development. We identified many overlapping genes in each process including neural crest-related genes (Hoxa1, Hoxa4, and Hand2, etc) and the second heart field-related genes (Tbx1, Isl1, and Fgf10, etc). Moreover, we found that regulation of epithelial-to-mesenchymal transition, cell adhesion, and retinol metabolism are the active pathways involved in the network via potential interactions with many of the identified genes to form DA-specific endothelia. In conclusion, the present study uncovered several significant differences of the transcriptional profile between the DA and aortic ECs. Newly identified DA endothelium-dominant genes may play an important role in DA-specific functional and morphologic characteristics.
Understanding Older Users' Acceptance of Wearable Interfaces for Sensor-based Fall Risk Assessment

Algorithms processing data from wearable sensors promise to more accurately predict risks of falling -- a significant concern for older adults. Substantial engineering work is dedicated to increasing the prediction accuracy of these algorithms; yet fewer efforts are dedicated to better engaging users through interactive visualizations in decision-making using these data. We present an investigation of the acceptance of a sensor-based fall risk assessment wearable device. A participatory design was employed to develop a mobile interface providing visualizations of sensor data and algorithmic assessments of fall risks. We then investigated the acceptance of this interface and its potential to motivate behavioural changes through a field deployment, which suggested that the interface and its belt-mounted wearable sensors are perceived as usable. We also found that providing contextual information for fall risk estimation combined with relevant practical fall prevention instructions may facilitate the acceptance of such technologies, potentially leading to behaviour change.
Preservation of Hearing Following Cochlear Implantation Using Different Steroid Therapy Regimens: A Prospective Clinical Study

Background A prospective clinical study was conducted to assess different regimens of steroid therapy and preservation of hearing following cochlear implantation. Material/Methods Study participants were ≥18 years-of-age, with a cochlear duct length ≥27.1 mm measured by computed tomography (CT), with hearing sound levels in the range of 10–120 decibels (dB) and sound frequencies of 125–250 hertz (Hz); sound levels of 35–120 dB and frequencies of 500–1,000 Hz; sound levels of 75–120 dB and frequencies of 2,000–8,000 Hz. Study exclusion criteria included diseases with contraindications for steroid therapy or medications that increased the effects of steroids. Patients had cochlear implantation and were divided into three treatment groups: intravenous (IV) steroid therapy (standard steroid therapy): combined oral and IV steroid therapy (prolonged steroid therapy); and a control group (cochlear implantation without steroid therapy). Hearing preservation was established by pure tone audiometry based on the pre-operative and postoperative average hearing thresholds according to the formula developed by the HEARRING Network. Results There were 36 patients included in the study. In all cases, the cochlear implant electrode was inserted via the round window approach with a straight electrode length of 28 mm. Patients with combined oral and IV steroid therapy (prolonged steroid therapy) had better results when compared with patients with intravenous (IV) steroid therapy (standard steroid therapy) and the control group. Conclusions Prolonged steroid therapy using combined oral and IV steroids stabilized hearing thresholds and preserved hearing in adult patients following cochlear implantation.
Estimating the Intra-taxa Diversity, Population Genetic Structure, and Evolutionary Pathways of Cryptococcus neoformans and Cryptococcus gattii

Members of the Cryptococcus complex, includes Cryptococcus neoformans (most common fungal infection of the brain) and Cryptococcus gattii (high-impact emerging pathogen worldwide). Currently, the fungal multilocus sequence typing database (Fungal MLST Database) constitutes a valuable data repository of the genes used for molecular typing of these pathogens. We analyzed the data available in the Fungal MLST Database for seven housekeeping genes, with the aim to evaluate its contribution in the description of intra-taxa diversity, population genetic structure, and evolutionary patterns. Although the Fungal MLST Database has a greater number of reports for C. neoformans (n = 487) than for C. gattii (n = 344), similar results were obtained for both species in terms of allelic diversity. Phylogenetic reconstructions revealed grouping by molecular type in both species and allowed us to propose differences in evolutionary patterns (gradualism in the case of C. neoformans and punctuated evolution in the case of C. gattii). In addition, C. neoformans showed a population genetic structure consisting of 37 clonal complexes (CCs; CC1 being predominant), high crosslinking [without sequence type (ST) grouping by molecular type], marked divergence events in phylogenetic analysis, and few introgression events (mainly between VNI and VNIV). By contrast, C. gattii showed 50 CCs (with greater homogeneity in ST number by CC) and clustering by molecular type with marked crosslinking events in phylogenetic networks being less evident. Understanding relationships at the molecular level for species of the Cryptococcus complex, based on the sequences of the housekeeping genes, provides information for describing the evolutionary history of these emerging pathogens.
The effect of musical expertise on the representation of space

Consistent evidence suggests that pitch height may be represented in a spatial format, having both a vertical and a horizontal representation. The spatial representation of pitch height results into response compatibility effects for which high pitch tones are preferentially associated to up-right responses, and low pitch tones are preferentially associated to down-left responses (i.e., the Spatial-Musical Association of Response Codes (SMARC) effect), with the strength of these associations depending on individuals’ musical skills. In this study we investigated whether listening to tones of different pitch affects the representation of external space, as assessed in a visual and haptic line bisection paradigm, in musicians and non musicians. Low and high pitch tones affected the bisection performance in musicians differently, both when pitch was relevant and irrelevant for the task, and in both the visual and the haptic modality. No effect of pitch height was observed on the bisection performance of non musicians. Moreover, our data also show that musicians present a (supramodal) rightward bisection bias in both the visual and the haptic modality, extending previous findings limited to the visual modality, and consistent with the idea that intense practice with musical notation and bimanual instrument training affects hemispheric lateralization.
Comparison of linear and angular measurements using two-dimensional conventional methods and three-dimensional cone beam CT images reconstructed from a volumetric rendering program in vivo.

OBJECTIVE The aim of this study was to compare the linear and angular measurements made on two-dimensional (2D) conventional cephalometric images and three-dimensional (3D) cone beam CT (CBCT) generated cephalograms derived from a 3D volumetric rendering program. METHODS Pre-treatment cephalometric digital radiographs of 11 patients and their corresponding CBCT images were randomly selected. The digital cephalometric radiographs were traced using Vista Dent OC (GAC International, Inc Bohemia, NY) and by hand. CBCT and Maxilim® (Medicim, Sint-Niklass, Belgium) software were used to generate cephalograms from the CBCT data set that were then linked to the 3D hard-tissue surface representations. In total, 16 cephalometric landmarks were identified and 18 widely used measurements (11 linear and 7 angular) were performed by 2 independent observers. Intraobserver reliability was assessed by calculating intraclass correlation coefficients (ICC), interobserver reliability was assessed with Student t-test and analysis of variance (ANOVA). Mann-Whitney U-tests and Kruskal-Wallis H tests were also used to compare the three methods (P < 0.05). RESULTS The results demonstrated no statistically significant difference between interobserver analyses for CBCT-generated cephalograms (P < 0.05), except for Gonion-Menton (Go-Me) and Condylion-Gnathion (Co-Gn). Intraobserver examinations showed low ICCs, which was an indication of poor reproducibility for Go-Me and Sella-Nasion (S-N) in CBCT-generated cephalograms and poor reproducibility for Articulare-Gonion (Ar-Go) in the 2D hand tracing method (P < 0.05). No statistical significance was found for Vista Dent OC measurements (P > 0.05). CONCLUSIONS Measurements from in vivo CBCT-generated cephalograms from Maxilim® software were found to be similar to conventional images. Thus, owing to higher radiation exposure, CBCT examinations should only be used when the inherent 3D information could improve the outcome of treatment.
Improving malware detection using multi-view ensemble learning

The huge influx of new malware is created every day, and those malware have not been previously seen in the wild. Current anti-virus software uses byte signature to identify known malware and has little hope of identifying new malware. Researchers have proposed several malware detection methods based on byte n-grams, opcode n-grams, and format information, and those methods partially capture the distinguishable information between benign and malicious programs. In this study, we design two schemes to incorporate the aforementioned three single-view features and fully exploit complementary information of those features to discover the true nature of a program. Two datasets are used to evaluate new malware detection performance and generalization performance of the proposed schemes. Experimental results indicate that the proposed schemes increase the detection rate of new malware, improve the generalization performance of learning model, and reduce the false alarm rate to 0%. Because malware is hard to disguise itself in every feature view, the proposed schemes are more robust and not easy to be deceived. Copyright © 2016 John Wiley & Sons, Ltd.
Canine tooth dimorphism: An adjunct for establishing sex identity

Background: Teeth are an excellent material for genetic, odontological and forensic investigations and research purpose. From all the teeth, the mandibular canines are found to exhibit sexual dimorphism. However, very few studies have been published on maxillary canine's measurements. Aims: 1. To find out utility of maxillary and mandibular canine width as a tool for sex determination in Central Indian population. 2. To find out the average size of canines in males and females of Central Indian population. 3. To compare the findings with National and International studies Materials and Methods: The present study was conducted in 100 cases in the age group of 17-21 years. Mesiodistal width of right and left mandibular and maxillary canines were measured on the casts with digital calliper and subjected to statistical analysis. Statistical Analysis: Statistical analysis was done to assess sex difference using Students “t” test (paired). Results and Conclusions: It was seen that a definite statistically significant sexual dimorphism exists when mandibular and maxillary canine measurements were compared. Thus, it can be suggested that canine width measurements can be used as an adjunct for sex identification purpose in Central Indian Population.
A hierarchical clustering method for dimension reduction in joint analysis of multiple phenotypes

Genome‐wide association studies (GWAS) have become a very effective research tool to identify genetic variants of underlying various complex diseases. In spite of the success of GWAS in identifying thousands of reproducible associations between genetic variants and complex disease, in general, the association between genetic variants and a single phenotype is usually weak. It is increasingly recognized that joint analysis of multiple phenotypes can be potentially more powerful than the univariate analysis, and can shed new light on underlying biological mechanisms of complex diseases. In this paper, we develop a novel variable reduction method using hierarchical clustering method (HCM) for joint analysis of multiple phenotypes in association studies. The proposed method involves two steps. The first step applies a dimension reduction technique by using a representative phenotype for each cluster of phenotypes. Then, existing methods are used in the second step to test the association between genetic variants and the representative phenotypes rather than the individual phenotypes. We perform extensive simulation studies to compare the powers of multivariate analysis of variance (MANOVA), joint model of multiple phenotypes (MultiPhen), and trait‐based association test that uses extended simes procedure (TATES) using HCM with those of without using HCM. Our simulation studies show that using HCM is more powerful than without using HCM in most scenarios. We also illustrate the usefulness of using HCM by analyzing a whole‐genome genotyping data from a lung function study.
Cronobacter species (formerly known as Enterobacter sakazakii) in powdered infant formula: a review of our current understanding of the biology of this bacterium

Cronobacter species (formerly known as Enterobacter sakazakii) are opportunistic pathogens that can cause necrotizing enterocolitis, bacteraemia and meningitis, predominantly in neonates. Infection in these vulnerable infants has been linked to the consumption of contaminated powdered infant formula (PIF). Considerable research has been undertaken on this organism in the past number of years which has enhanced our understanding of this neonatal pathogen leading to improvements in its control within the PIF production environment. The taxonomy of the organism resulted in the recognition of a new genus, Cronobacter, which consists of seven species. This paper presents an up‐to‐date review of our current knowledge of Cronobacter species. Taxonomy, genome sequencing, current detection protocols and epidemiology are all discussed. In addition, consideration is given to the control of this organism in the manufacturing environment, as a first step towards reducing the occurrence of this pathogen in PIF.
Hard and Soft Skills in Preparing GIS Professionals: Comparing Perceptions of Employers and Educators

Organizations that hire GIS professionals look for entry‐level employees with specialized technical skills but also other competencies such as effective communication and a capacity to think critically and creatively. Indeed, the success of GIS projects and initiatives often depends on individuals who possess a combination of specialized GIS skills and more general competencies that influence their ability to collaborate and manage resources. This article presents findings from a survey of GIS employers and educators concerning the importance of hard and soft skills among entry‐level GIS professionals. A key finding is the high level of consistency in ratings assigned by employers and educators concerning hard skills such as data editing and GIS analysis and soft skills including problem solving and adaptability. However, the groups were less similar in ratings assigned to data capture skills, project management, and written/verbal skills. GIS qualifications were also compared, revealing a greater emphasis on internships among educators and higher ratings assigned to academic GIS certificates among employers.
Improving user authentication on mobile devices: a touchscreen graphical password

Typing text passwords is challenging when using touchscreens on mobile devices and this is becoming more problematic as mobile usage increases. We designed a new graphical password scheme called Touchscreen Multi-layered Drawing (TMD) specifically for use with touchscreens. We conducted an exploratory user study of three existing graphical passwords on smart phones and tablets with 31 users. From this, we set our design goals for TMD to include addressing input accuracy issues without having to memorize images, while maintaining an appropriately secure password space. Design features include warp cells which allow TMD users to continuously draw their passwords across multiple layers in order to create more complex passwords than normally possible on a small screen. We compared the usability of TMD to Draw A Secret (DAS) on a tablet computer and a smart phone with 90 users. Results show that TMD improves memorability, addresses the input accuracy issues, and is preferred as a replacement for text passwords on mobile devices.
A propensity score-matched case-control comparative study of laparoscopic and open gastrectomy for locally advanced gastric carcinoma.

PURPOSE The aim of this study was to compare the surgical and long-term outcomes of laparoscopic and open gastrectomy with radical intent for locally advanced gastric carcinoma in case-controlled patient groups using the propensity score. METHODS Between January 2009 and December 2014, 389 patients who underwent gastrectomy with radical intent for locally advanced gastric carcinoma were enrolled. These patients were divided into two groups according to the method of operation: the laparoscopy group (patients who underwent laparoscopic gastrectomy) and the open group (patients who underwent open gastrectomy). To correct different demographic and clinical factors in the two groups, a propensity score matching was used at a 1:1 ratio, and, finally, 184 patients were enrolled in this study, 92 patients in each group. Preoperative characteristics, surgical results, and long-term results were analyzed. RESULTS Preoperative baseline variables were well balanced in both groups. There were no differences of the extent of surgery between the two groups. With the exception of shorter postoperative hospital stay and less blood loss in the laparoscopy group as compared with the open group, there were no significant differences in surgical, pathological, and long-term outcomes. The 5-year overall survival rates were 57% in the laparoscopy group and 50% in the open group (p=0.606). The 5-year disease-free survival rates were 48% in the laparoscopy group and 42% in the open group (p=0.515). CONCLUSION Laparoscopic gastrectomy for locally advanced gastric carcinoma is safe, and long-term outcomes were comparable to those who underwent open resection.
ADI 1050-6 Mechanical Behavior at Different Strain Rates and Temperatures

An experimental characterization of the austempered ductile iron ISO 17804/JS/1050-6/S was performed carrying out tensile tests under different strain rates, temperatures and stress triaxiality levels. Then, composing a yield function surface, a hardening relation, and a damage criterion, a constitutive model was developed to describe the salient features of the observed macroscopic response. In particular, the Mohr-Coulomb yield function was selected to account for the pressure effect observed on the yield surface. A new hardening relation was proposed in order to account for both strain rate and temperature effects. The Bonora’s damage model, developed in the framework of the continuum damage mechanics, was adopted to capture the failure condition under different stress triaxiality levels. The damage model was appropriately modified to account for the effect of strain rate and temperature on the failure strain.
Respiratory Effects of Insulin Sensitisation with Metformin: A Prospective Observational Study

Abstract The mechanism for the association between diabetes mellitus and lung function impairment is unknown, as are any respiratory effects of antidiabetic agents. We aimed to assess whether treatment with metformin, an oral insulin-sensitising agent, improved lung function or symptoms in individuals with COPD and glucose intolerance. A prospective open-label observational study was conducted. Participants with moderate or severe COPD, BMI > 25 kg/m2, and type 2 diabetes mellitus or impaired glucose tolerance took metformin twice daily for 6 months. Clinical outcomes included St George's Respiratory Questionnaire (SGRQ), transition dyspnoea index, and incremental shuttle walk test. Physiological outcomes including pulmonary function tests, exhaled nitric oxide, respiratory mouth pressures and handgrip strength. In total, 17 participants completed the study. SGRQ score improved by a median of 5 points, and TDI scores improved by 2 points. Inspiratory mouth pressures increased by 7.5 cmH2O. There were trends to improvements in hyperinflation, gas trapping and shuttle walk distance. Spirometry and exhaled nitric oxide were unchanged. In this proof-of-concept study, metformin was associated with improved dyspnoea and health status in COPD, possibly related to increased inspiratory muscle strength. These and other endpoints should be examined in a definitive study.