Miracle-dz/UniFAR-FTUs huggingface dataset:
Lateral incisor root resorption and active orthodontic treatment in the early mixed dentition.

AIM To evaluate the presence of root resorption in the lateral incisor after active orthodontic treatment in the early mixed dentition. METHODS Twenty-six children treated at the Children's Clinic of the Schulich School of Medicine and Dentistry at the University of Western Ontario were examined radiographically for lateral incisors root resorption before and after early active treatment to align upper incisors (2 x 4 appliance). In addition, canine inclinations to the midline and to the long axis of the lateral incisor as well as the most medial position of the canine crown were measured as potential risk factors for root resorption. RESULTS 8% (4) of the lateral incisors exhibited root resorption and the mean crown-to-root ratio of these teeth was significantly higher than that for lateral incisors not exhibiting root resorption. Similarly, mean canine inclinations to the midline and to the long axis of the lateral incisor were also significantly higher for the root resorption group. No association could be found between the most medial position of the canine crown and root resorption in the lateral incisor. CONCLUSION This study showed that active orthodontic treatment in the early mixed dentition does not increase the risk for root resorption in the lateral incisors as long as the clinician takes into consideration canine inclinations and their potential effect on root resorption. Limitations inherent to radiographic assessment are acknowledged.
A Probabilistic Analysis of the Rocchio Algorithm with TFIDF for Text Categorization

Abstract : A probabilistic analysis of the Rocchio relevance feedback algorithm, one of the most popular learning methods from information retrieval, is presented in a text categorization framework. The analysis results in a probabilistic version of the Rocchio classifier and offers an explanation for the TFIDF word weighting heuristic. The Rocchio classifier, its probabilistic variant and a standard naive Bayes classifier are compared on three text categorization tasks. The results suggest that the probabilistic algorithms are preferable to the heuristic Rocchio classifier.
Does Innovation Help the Good or the Poor Performing Firms?

Using firm-level innovation data for a large sample of Slovenian firms in the period 1996-2002, the paper finds surprising results that innovation is not benefitting all firms. We find that only manufacturing firms with below average productivity growth (the lowest four deciles) are likely to experience significant benefits from successful innovation, while faster growing firms do not extract any additional benefits from innovation. This evidence demonstrates how innovation can affect the observed convergence of firms in terms of productivity in the manufacturing sector.
Consumption of a high‐fat diet, but not regular endurance exercise training, regulates hypothalamic lipid accumulation in mice

‘Lipotoxicity’ refers to the excessive accumulation of lipids in non‐adipose tissues that causes cellular dysfunction and, in severe cases, cell death. Lipotoxicity is often present in obesity. It is unknown whether lipotoxicity occurs in the hypothalamus of the brain, an area involved in the regulation of feeding behaviour and energy balance. We show that high‐fat feeding results in increased lipid content in the hypothalamus, including triacylglycerol, diacylglycerol and ceramide, which was not reduced with 6 weeks of exercise training. The obese leptin‐deficient ob/ob mouse fed a chow diet had normal hypothalamic lipid content. These data show that dietary lipids regulate hypothalamic lipid accumulation, which is not readily reversed by exercise training.
A Robust Fuzzy Local Information C-Means Clustering Algorithm

This paper presents a variation of fuzzy c-means (FCM) algorithm that provides image clustering. The proposed algorithm incorporates the local spatial information and gray level information in a novel fuzzy way. The new algorithm is called fuzzy local information C-Means (FLICM). FLICM can overcome the disadvantages of the known fuzzy c-means algorithms and at the same time enhances the clustering performance. The major characteristic of FLICM is the use of a fuzzy local (both spatial and gray level) similarity measure, aiming to guarantee noise insensitiveness and image detail preservation. Furthermore, the proposed algorithm is fully free of the empirically adjusted parameters (a, ¿g, ¿s, etc.) incorporated into all other fuzzy c-means algorithms proposed in the literature. Experiments performed on synthetic and real-world images show that FLICM algorithm is effective and efficient, providing robustness to noisy images.
Anorogenic plateau formation: The importance of density changes in the lithosphere

[1] Away from active plate boundaries the relationships between spatiotemporal variations in density and geothermal gradient are important for understanding the evolution of topography in continental interiors. In this context the classic concept of the continental lithosphere as comprising three static layers of different densities (upper crust, lower crust, and upper mantle) is not adequate to assess long-term changes in topography and relief in regions associated with pronounced thermal anomalies in the mantle. We have therefore developed a one-dimensional model, which is based on thermodynamic equilibrium assemblage computations and deliberately excludes the effects of melting processes like intrusion or extrusions. Our model calculates the “metamorphic density” of rocks as a function of pressure, temperature, and chemical composition. It not only provides a useful tool for quantifying the influence of petrologic characteristics on density, but also allows the modeled “metamorphic” density to be adjusted to variable geothermal gradients and applied to different geodynamic environments. We have used this model to simulate a scenario in which the lithosphere-asthenosphere boundary is subjected to continuous heating over a long period of time (130 Ma), and demonstrate how an anorogenic plateau with an elevation of 1400 m can be formed solely as a result of heat transfer within the continental lithosphere. Our results show that, beside dynamic topography (of asthenospheric origin), density changes within the lithosphere have an important impact on the evolution of anorogenic plateaus.
“I Wanted to Rebel, But There They Hit Me Even Harder”

This study examined women offenders’ accounts of their pathways to substance abuse and crime and the intersection between them, to reach a holistic understanding that captures the dynamics of victimization, agency, and gender. Discourse analyses of the accounts of 11 Israeli women offenders indicated differential use of two discourses. Five participants used the victimization discourse, which viewed substance abuse as an attempt to medicate the self that was injured following victimization experiences; two used the agency discourse, which viewed substance abuse as a way to experience pleasure, leisure, and control over their destiny. Four of the participants used these two contradictory discourses simultaneously. The findings indicate the absence of a cultural discourse that encompasses women’s complex experience of gender, victimization, and agency. Possible implications for intervention are discussed.
Recognition of historic influenza epidemics from parish burial records: a test of prediction from a new hypothesis of influenzal epidemiology

SUMMARY On the current conception of the epidemiology of epidemic influenza, as caused by a mechanism of direct spread of the virus from the sick, epidemics must have travelled much more slowly in former times than at present. In contrast, a new hypothesis involving virus latency with seasonal reactivation predicts that in previous centuries influenza epidemics would have spread across the country at much the same speed as in the twentieth century. The study of burial registers in Gloucestershire parishes reported in this paper shows that lethal influenza epidemics at least as early as the sixteenth century can be recognized and dated as at present by the characteristic brief but large excess mortality that they cause. Examples are given showing that the character of the excess mortality caused by lethal influenza has not changed significantly over the centuries, a finding that supports the prediction of the new hypothesis but would not be expected on the current conception of influenzal epidemiology. In each century, influenzal excess mortalities in Gloucestershire parishes coincided with the date of the relevant influenza epidemic as recorded from widely different parts of Britain, thus further supporting the prediction of the new hypothesis as against current conceptions.
Is there an association between insomnia symptoms, aggressive behavior, and suicidality in adolescents?

Purpose Sleep disturbances are a common problem during adolescence. Often there is a relationship with the mental health of the affected person. The existing literature concerning the link between sleep disturbances and aggressive behavior and sleep disturbances and suicidality during adolescence shows no clear results. The present study tested a mediation model to prove the relation between sleep problems, aggressive behavior, and suicidality during adolescence. To take the link between suicidality and depression into account, the amount of depressive symptoms was included into the mediation model. Methods A sample of 93 adolescents aged 14–18 years (30% male) was studied. A survey was conducted to interview the adolescents about their mental health, sleep-related behaviors, aggressive behavior, and suicidality. Results Sleep problems and suicidality measures were significantly related to each other. Furthermore, aggressive behavior and suicidality showed a significant relationship. The expected link between sleep problems and aggressive behavior was not significant. For the mediation model, no significant influence of aggressive behavior on the relationship between the amount of sleep problems and suicidality was found. However, the impact of depressive symptoms on the relationship between sleep problems and suicidality was significant. Conclusion Sleep problems and overall suicidality in adolescents are significantly connected, even after adjusting for several possible influencing factors. Aggressive behavior could not be confirmed as a mediator for the association between sleep problems and suicidality in adolescents. Further studies to examine the link between insomnia symptoms, aggressive behavior, and suicidality in adolescents are necessary.
BOLD fMRI of C-Fiber Mediated Nociceptive Processing in Mouse Brain in Response to Thermal Stimulation of the Forepaws

Functional magnetic resonance imaging (fMRI) in rodents enables non-invasive studies of brain function in response to peripheral input or at rest. In this study we describe a thermal stimulation paradigm using infrared laser diodes to apply noxious heat to the forepaw of mice in order to study nociceptive processing. Stimulation at 45 and 46°C led to robust BOLD signal changes in various brain structures including the somatosensory cortices and the thalamus. The BOLD signal amplitude scaled with the temperature applied but not with the area irradiated by the laser beam. To demonstrate the specificity of the paradigm for assessing nociceptive signaling we administered the quaternary lidocaine derivative QX-314 to the forepaws, which due to its positive charge cannot readily cross biological membranes. However, upon activation of TRPV1 channels following the administration of capsaicin the BOLD signal was largely abolished, indicative of a selective block of the C-fiber nociceptors due to QX-314 having entered the cells via the now open TRPV1 channels. This demonstrates that the cerebral BOLD response to thermal noxious paw stimulation is specifically mediated by C-fibers.
Neuregulin 1 Expression Is a Predictive Biomarker for Response to AV-203, an ERBB3 Inhibitory Antibody, in Human Tumor Models

Purpose: ERBB3 is overexpressed in a broad spectrum of human cancers, and its aberrant activation is associated with tumor pathogenesis and therapeutic resistance to various anticancer agents. Neuregulin 1 (NRG1) is the predominant ligand for ERBB3 and can promote the heterodimerization of ERBB3 with other ERBB family members, resulting in activation of multiple intracellular signaling pathways. AV-203 is a humanized IgG1/κ ERBB3 inhibitory antibody that completed a first-in-human phase I clinical trial in patients with advanced solid tumors. The purpose of this preclinical study was to identify potential biomarker(s) that may predict response to AV-203 treatment in the clinic. Experimental Design: We conducted in vivo efficacy studies using a broad panel of xenograft models representing a wide variety of human cancers. To identify biomarkers that can predict response to AV-203, the relationship between tumor growth inhibition (TGI) by AV-203 and the expression levels of ERBB3 and NRG1 were evaluated in these tumor models. Results: A significant correlation was observed between the levels of NRG1 expression and TGI by AV-203. In contrast, TGI was not correlated with ERBB3 expression. The correlation between the levels of NRG1 expression in tumors and their response to ERBB3 inhibition by AV-203 was further validated using patient-derived tumor explant models. Conclusions: NRG1 is a promising biomarker that can predict response to ERBB3 inhibition by AV-203 in preclinical human cancer models. NRG1 warrants further clinical evaluation and validation as a potential predictive biomarker of response to AV-203. Clin Cancer Res; 21(5); 1106–14. ©2014 AACR.
A Quantitative Analysis of Distortions in Managerial Forecasts

This paper quantifies the economic costs of distortions in managerial forecasts. We match a unique managerial survey run by the Bank of Italy with administrative data on firm balance sheets and income statements. The resulting dataset allows us to observe a long panel of managerial forecast errors for a sample of firms representative of the Italian economy. We show that managerial forecast errors are positively and significantly autocorrelated. This persistence in forecast error is consistent with managerial underreaction to new information. To quantify the economic significance of this forecasting bias, we estimate a dynamic equilibrium model with heterogeneous firms and distorted expectations. The estimated model matches not only the persistence of forecast errors, but the empirical link between investment and managerial forecasts. Relative to a counterfactual with rational expectations, we find that managers exhibit large forecasting biases, which lead to significant distortions in firm-level investment. These distortions, however, imply limited loss in firm value. In general equilibrium, the estimated model leads to negligible aggregate efficiency losses from distorted forecasts.
Ultrahigh-Acceleration Moving-Permanent-Magnet Linear Synchronous Motor With a Long Working Range

This paper describes a linear motor design for ultrahigh acceleration and high velocity, as well as the driving performance of the motor. First, because of its ease of control, a moving-permanent-magnet linear synchronous motor (MPM LSM) was selected. The overall structure of the motor, which consists of a table to which the permanent magnets (PMs) are attached and two fixed electromagnet (EM) lines between which the PMs move, was selected based on the simplicity of the structure and the ease of gap adjustment. The dimensions of the EMs and PMs are optimized numerically to achieve a high thrust density that can provide an acceleration of 100G or greater to the mover, which comprises PMs, spacers, and a frame. The prototype MPM LSM has a working range of 1.5 m. The mover, including the guide parts, has a length of 444 mm and a mass of 4.79 kg. The measured peak thrust was greater than 5 × 103 N, and the measured average thrust was 4.03 × 103 N. The prototype driven by a rectangular current command produced a maximum acceleration of greater than 100G and a velocity higher than 12 m/s for a moving distance of 0.6 m.
Chemical Elemental Distribution and Soil DNA Fingerprints Provide the Critical Evidence in Murder Case Investigation

Background The scientific contribution to the solution of crime cases, or throughout the consequent forensic trials, is a crucial aspect of the justice system. The possibility to extract meaningful information from trace amounts of samples, and to match and validate evidences with robust and unambiguous statistical tests, are the key points of such process. The present report is the authorized disclosure of an investigation, carried out by Attorney General appointment, on a murder case in northern Italy, which yielded the critical supporting evidence for the judicial trial. Methodology/Principal Findings The proportional distribution of 54 chemical elements and the bacterial community DNA fingerprints were used as signature markers to prove the similarity of two soil samples. The first soil was collected on the crime scene, along a corn field, while the second was found in trace amounts on the carpet of a car impounded from the main suspect in a distant location. The matching similarity of the two soils was proven by crossing the results of two independent techniques: a) elemental analysis via inductively coupled plasma mass spectrometry (ICP-MS) and optical emission spectrometry (ICP-OES) approaches, and b) amplified ribosomal DNA restriction analysis by gel electrophoresis (ARDRA). Conclusions Besides introducing the novel application of these methods to forensic disciplines, the highly accurate level of resolution observed, opens new possibilities also in the fields of soil typing and tracking, historical analyses, geochemical surveys and global land mapping.
AIMD Congestion Control : Stability , TCP-friendliness , Delay Performance

In this report, a class of generalized AIMD/RED (Additive Increase and Multiplicative Decrease/Random Early Detection) model for the Internet is studied. Sufficient conditions for asymptotic stability by using indirect Lyapunov method are obtained for both the homogeneous-flow system and the heterogeneous-flow system. The TCP (Transmission Control Protocol)-friendly condition and average queuing delay are also derived. The analytical results can provide important guidelines for system parameters setting, in order to efficiently and fairly support emerging multimedia applications with a wide variety of Quality of Service (QoS) requirements in future heterogeneous networks. Numeric results by Matlab and simulation results by NS-2 are given to verify the model and validate the analysis.
Free availability of high-energy foods led to energy over-ingestion and protein under-ingestion in choice-fed broilers.

The objective of this study was to compare energy and protein content of the diet selected by choice-fed broilers with that of broilers fed a balanced diet. One hundred and eighty 1-day-old male broilers were randomly assigned in groups of 10 to one of three experimental treatments (n = 6). Control broilers were fed a standard balanced diet, whereas choice-fed broilers were fed three foods which were more concentrated (Choice C+ treatment) or less concentrated (Choice C- treatment) in protein, carbohydrate or fat. We evaluated food intake behavior, nutrient intake, and performance parameters of broilers from 2 to 7 weeks of age. Choice C+ broilers showed enhanced preference for the high-fat food, which led to higher energy intake and lower protein intake than those of control broilers at 2 to 4 weeks of age. Body weight, weight gain and feed conversion efficiency were negatively affected by diet selection of Choice C+ broilers. Choice C- broilers selected a balanced diet, and showed performance parameters similar to those of control broilers. Our results supported the hypothesis that free availability of high-energy foods bias ingestive behavior of choice-fed broilers toward selecting a diet with higher energy and lower protein than needed for normal growth.
Abstractive Meeting Summarization with Entailment and Fusion

We propose a novel end-to-end framework for abstractive meeting summarization. We cluster sentences in the input into communities and build an entailment graph over the sentence communities to identify and select the most relevant sentences. We then aggregate those selected sentences by means of a word graph model. We exploit a ranking strategy to select the best path in the word graph as an abstract sentence. Despite not relying on the syntactic structure, our approach significantly outperforms previous models for meeting summarization in terms of informativeness. Moreover, the longer sentences generated by our method are competitive with shorter sentences generated by the previous word graph model in terms of grammaticality.
Does light inhibit ethylene production in leaves?

The effect of light on the rate of ethylene production was monitored using two different techniques-leaf segments incubated in closed flasks versus intact plants in a flow-through open system. Three different plants were used, viz sunflower (Helianthus annuus), tomato (Lycopersicon esculentum), and soybean (Glycine max). Experiments were conducted both in the presence and absence of 1-aminocyclopropane-1-carboxylic acid (ACC). The results obtained indicate that, in all three species studied, light strongly inhibits ethylene production when cut leaf segments are incubated in the presence of ACC in closed flasks. When ethylene measurements are made with ACC-sprayed intact plants using a continuous flow system, the effect of light on ethylene production is only marginal. In leaf segments of sunflower and soybean incubated only in distilled H(2)O in closed flasks, light promotes ethylene production. In tomato, there is no difference between the rate of ethylene production between light and darkness under such conditions. When measurements are made with intact plants in a continuous flow system, the rate of ethylene production is almost identical in light and darkness, in the three plants studied.It is concluded that the effect of light on cut leaf segments incubated in the presence of ACC in closed flasks can be attributed to the techniques used for these measurements. Light has little effect on ethylene production by intact plants in an open system.