Miracle-dz/UniFAR-FTUs huggingface dataset:
Alzheimer's Disease Neurodegenerative Biomarkers Are Associated with Decreased Cognitive Function but Not β-Amyloid in Cognitively Normal Older Individuals

β-Amyloid (Aβ) plaque deposition and neurodegeneration within temporoparietal and hippocampal regions may indicate increased risk of Alzheimer's disease (AD). This study examined relationships between AD biomarkers of Aβ and neurodegeneration as well as cognitive performance in cognitively normal older individuals. Aβ burden was quantified in 72 normal older human subjects from the Berkeley Aging Cohort (BAC) using [11C] Pittsburgh compound B (PIB) positron emission tomography. In the same individuals, we measured hippocampal volume, as well as glucose metabolism and cortical thickness, which were extracted from a template of cortical AD-affected regions. The three functional and structural biomarkers were merged into a highly AD-sensitive multimodality biomarker reflecting neural integrity. In the normal older individuals, there was no association between elevated PIB uptake and either the single-modality or the multimodality neurodegenerative biomarkers. Lower neural integrity within the AD-affected regions and a control area (the visual cortex) was related to lower scores on memory and executive function tests; the same association was not found with PIB retention. The relationship between cognition and the multimodality AD biomarker was stronger in individuals with the highest PIB uptake. The findings indicate that neurodegeneration occurs within AD regions regardless of Aβ deposition and accounts for worse cognition in cognitively normal older people. The impact of neural integrity on cognitive functions is, however, enhanced in the presence of high Aβ burden for brain regions that are most affected in AD.
Cognitive and affective processes in social actions and decisions

The question of how we make, and how we should make judgments and decisions has occupied thinkers for many centuries. This thesis has the aim to add new evidences to clarify the brain’s mechanisms for decisions. The cognitive and the emotional processes of social actions and decisions are investigated with the aim to understand which brain areas are mostly involved. Four experimental studies are presented. A specific kind of population is involved in the first study (as well as in study III) concerning patients with lesion of ventromedial prefrontal cortex (vmPFC). This region is collocated in the ventral surface of frontal lobe, and it seems have an important role in social and moral decision in forecasting the negative emotional consequences of choice. In study I, it is examined whether emotions, specifically social emotions subserved by the vmPFC, affect people’s willingness to trust others. In study II is observed how incidental emotions could encourage trusting behaviour, especially when individuals are not aware of emotive stimulation. Study III has the aim to gather a direct psychophysiological evidence, both in healthy and neurologically impaired individuals, that emotions are crucially involved in shaping moral judgment, by preventing moral violations. Study IV explores how the moral meaning of a decision and its subsequent action can modulate the basic component of action such as sense of agency.
A Split Random Reaction Method for Stiff and Nonstiff Chemically Reacting Flows

In this paper, a new fractional step method is proposed for simulating stiff and nonstiff chemically reacting flows. In stiff cases, a well-known spurious numerical phenomenon, i.e. the incorrect propagation speed of discontinuities, may be produced by general fractional step methods due to the under-resolved discretization in both space and time. The previous random projection method has been successfully applied for stiff detonation capturing in under-resolved conditions. Not to randomly project the intermediate state into two presumed equilibrium states (completely burnt or unburnt) as in the random projection method, the present study is to randomly choose the time-dependent advance or stop of a reaction process. Each one-way reaction has been decoupled from the multi-reaction kinetics using operator splitting and the local smeared temperature due to numerical dissipation of shock-capturing schemes is compared with a random one within two limited temperatures corresponding to the advance and its inverse states, respectively, to control the random reaction. The random activation or deactivation in the reaction step is thus promising to correct the deterministic accumulative error of the propagation of discontinuities. Extensive numerical experiments, including model problems and realistic reacting flows in one and two dimensions, demonstrate this expectation as well as the effectiveness and robustness of the method. Meanwhile, for nonstiff problems when spatial and temporal resolutions are fine, the proposed random method recovers the results as general fractional step methods, owing to the increasing possibility of activation with diminishing randomness by adding a shift term.
Sexual Dimorphism in the Corpus Callosum: A Characterization of Local Size Variations and a Classification Driven Approach to Morphometry

We present two complementary quantitative approaches to the problem of characterizing morphometric variations between two distinct populations. The case presented focuses solely on local size variations, but the general method can easily be applied to other scalar morphometric quantities. The first method uses a statistical parametric map (SPM) to ascertain a P value, which indicates whether any statistically significant differences exist between the populations. The second method focuses on finding the best single measurement which can be used for classifying the two populations. For our case study midsagittal cross sections of the corpora callosa from a population of normal males and females are nonrigidly registered (spatially normalized) to an atlas. The resulting deformations are then used to ascertain (i) whether there are any statistically significant differences between the populations and (ii) whether these differences allow one to perform classification. We make use of the Jacobian of the deformation field and normalize it to account for overall volume changes allowing us to focus on differences which are more related to morphometry than scale. From the (SPM) approach to the problem we find evidence of statistically significant differences in the morphology between the populations. Using a linear discriminant function we find that these differences do not appear to be useful for classification. Thus, this dataset provides an example of how statistically significant effects may not be of much diagnostic value. They may be of interest to the research community, but of little value to the clinician.
Signet-ring squamous cell carcinoma in a dog

reappear, especially when, as in this study, there are exercise restrictions. The long-term effects of HMWSH joint injections have not been evaluated in this study. In the authors' experience, the effect of one to three injections of HMWSH on joint inflammation lasts between six and 12 months. However, if the treatment is repeated when clinical signs reappear, the effect may be shorter, since many of the cases treated suffer from progressive osteoarthritis. For many dogs though, periodic intraarticular treatment with HMWSH can keep arthritic joints functioning for years.
This Work Is Licensed under a Creative Commons Attribution 4.0 International License Sensitivity to the Temporal Structure of Rapid Sound Sequences — an Meg Study

Sensitivity to the temporal structure of rapid sound sequences-An MEG study. a b s t r a c t a r t i c l e i n f o Keywords: Time perception Magnetoencephalography MMN Offset response Omission response Auditory scene analysis entrainment To probe sensitivity to the time structure of ongoing sound sequences, we measured MEG responses, in human listeners , to the offset of long tone-pip sequences containing various forms of temporal regularity. If listeners learn sequence temporal properties and form expectancies about the arrival time of an upcoming tone, sequence offset should be detectable as soon as an expected tone fails to arrive. Therefore, latencies of offset responses are indicative of the extent to which the temporal pattern has been acquired. In Exp1, sequences were isochronous with tone inter-onset-interval (IOI) set to 75, 125 or 225 ms. Exp2 comprised of non-isochronous, temporally regular sequences , comprised of the IOIs above. Exp3 used the same sequences as Exp2 but listeners were required to monitor them for occasional frequency deviants. Analysis of the latency of offset responses revealed that the temporal structure of (even rather simple) regular sequences is not learnt precisely when the sequences are ignored. Pattern coding , supported by a network of temporal, parietal and frontal sources, improved considerably when the signals were made behaviourally pertinent. Thus, contrary to what might be expected in the context of an 'early warning system' framework, learning of temporal structure is not automatic, but affected by the signal's behavioural relevance. Introduction Sensitivity to the timing of sensory input plays a crucial role in the perception of, and efficient interaction with, the environment (Nobre et al., 2007). Due to the dynamic nature of sound, temporal information is perhaps especially relevant in the context of the auditory modality. Music or speech are often a prime example, but much more generally, the ability to make sense of acoustic scenes, including resolving the identity and current state of objects, requires the capacity to extract and retain the temporal patterning of the stimulus sequence. Tapping studies (see Repp, 2005 for review), a classic method for investigating sensitivity to temporal structure in sound, demonstrate that listeners can entrain to sequences of tones over a wide range of tempi and rhythmic patterns. The tapping profile often exhibits predictive properties — taps do not constitute reactions to a heard tone, but actually precedes the pacing — suggesting that …
Phase structure of lattice QCD for general number of flavors

We investigate the phase structure of lattice QCD for general number of flavors $N_F$. Based on numerical results combined with the result of the perturbation theory we propose the following picture: When $N_F \ge 17$, there is only a trivial fixed point and therefore the theory in the continuum limit is trivial. On the other hand, when $16 \ge N_F \ge 7$, there is a non-trivial fixed point and therefore the theory is non-trivial with anomalous dimensions, however, without quark confinement. Theories which satisfy both quark confinement and spontaneous chiral symmetry breaking in the continuum limit exist only for $N_F \le 6$.
Hypertension and appraisal of aversive stimuli

A review of the literature on the relationship between blood pressure and stressor exposure revealed a discrepancy between the results of studies based on objective measures of stressor exposure and studies based on self-reports. Whereas in the studies based on objective measures, a clear predominance of positive associations between blood pressure level and stressor exposure was found, in the studies based on self-reports, the results were highly inconsistent. Several moderator variables have been proposed that could explain the discrepancies found in the literature, such as awareness of hypertension and treatment. In studies in which these moderators were taken into account, inverse associations between blood pressure and selfreported stressor exposure have often been found. It is suggested that this result is brought about by altered appraisal of stressors in hypertensives.
Social Defeat: Impact on Fear Extinction and Amygdala-Prefrontal Cortical Theta Synchrony in 5-HTT Deficient Mice

Emotions, such as fear and anxiety, can be modulated by both environmental and genetic factors. One genetic factor is for example the genetically encoded variation of the serotonin transporter (5-HTT) expression. In this context, the 5-HTT plays a key role in the regulation of central 5-HT neurotransmission, which is critically involved in the physiological regulation of emotions including fear and anxiety. However, a systematic study which examines the combined influence of environmental and genetic factors on fear-related behavior and the underlying neurophysiological basis is missing. Therefore, in this study we used the 5-HTT-deficient mouse model for studying emotional dysregulation to evaluate consequences of genotype specific disruption of 5-HTT function and repeated social defeat for fear-related behaviors and corresponding neurophysiological activities in the lateral amygdala (LA) and infralimbic region of the medial prefrontal cortex (mPFC) in male 5-HTT wild-type (+/+), homo- (−/−) and heterozygous (+/−) mice. Naive males and experienced losers (generated in a resident-intruder paradigm) of all three genotypes, unilaterally equipped with recording electrodes in LA and mPFC, underwent a Pavlovian fear conditioning. Fear memory and extinction of conditioned fear was examined while recording neuronal activity simultaneously with fear-related behavior. Compared to naive 5-HTT+/+ and +/− mice, 5-HTT−/− mice showed impaired recall of extinction. In addition, 5-HTT−/− and +/− experienced losers showed delayed extinction learning and impaired recall of extinction. Impaired behavioral responses were accompanied by increased theta synchronization between the LA and mPFC during extinction learning in 5-HTT-/− and +/− losers. Furthermore, impaired extinction recall was accompanied with increased theta synchronization in 5-HTT−/− naive and in 5-HTT−/− and +/− loser mice. In conclusion, extinction learning and memory of conditioned fear can be modulated by both the 5-HTT gene activity and social experiences in adulthood, accompanied by corresponding alterations of the theta activity in the amygdala-prefrontal cortex network.
The Semantics of Collocational Patterns for Reporting Verbs

One of the hardest problems for knowledge extraction from machine readable textual sources is distinguishing entities and events that are part of the main story from those that are part of the narrative structure. Importantly, however, reported speech in newspaper articles explicitly links these two levels. In this paper, we illustrate what the lexical semantics of reporting verbs must incorporate in order to contribute to the reconstruction of story and context. The lexical structures proposed are derived from the analysis of semantic collocations over large text corpora.
Information Distance in Multiples

Information distance is a parameter-free similarity measure based on compression, used in pattern recognition, data mining, phylogeny, clustering and classification. The notion of information distance is extended from pairs to multiples (finite lists). We study maximal overlap, metricity, universality, minimal overlap, additivity and normalized information distance in multiples. We use the theoretical notion of Kolmogorov complexity which for practical purposes is approximated by the length of the compressed version of the file involved, using a real-world compression program.
Expression and localization of DNA topoisomerase II during rat spermatogenesis

The potential role(s) of DNA topoiosmerase II (topo II) during chromatin changes that characterize different stages of spermatogenesis was investigated in the rat by an analysis of the expression and localization of topo II mRNA and protein in individual spermatogenic cells. Expression of topo II was restricted to spermatogonia, spermatocytes, and round and early‐elongating spermatids. Two protein bands of 177 and 170 kDa were detected in immunoblots of spermatocytes and round spermatids, while bands of 148 and 142 kDa were prominent in preparations of elongating spermatids. Topo II levels and distribution patterns, as observed by immunofluorescent microscopy, exhibited cell type‐specific variations. Differences in topo II staining patterns were also apparent when nuclear matrices of spermatogenic cells were prepared with different extraction conditions. In addition to its possible function as a structural component, topo II, associated with nuclear matrix preparations from spermatogenic cells, possessed catalytic activity. These observations indicate that both the 177 and 170 kDa and the 148 and 142 kDa forms of topo II share similar structural and functional properties. Topo IIβ mRNA was transcribed in rat spermatogenic cells at 6.2 kb. Relative levels of topo IIβ mRNA were high in spermatogonia and spermatocytes, and decreased in both round and early‐elongating spermatids. Changes in topo II expression levels and localization patterns represent distinct stage‐specific markers for the maturation of spermatogenic cells, and are consistent with the involvement of topo II in mediating DNA modifications and chromatin changes during spermatogenesis. © 1996 Wiley‐Liss, Inc.
Minimal redundancy, low power bus coding

A new approach to low redundancy coding for reducing power dissipation in parallel on-chip, deep sub-micron buses is presented. It is shown that the new approach allows lower power dissipation than previous solutions in the given model, yielding reductions of 24% to 41% compared to uncoded transmission for the considered bus widths. Finally some important open problems are given.
Long-term seizure outcomes following amygdalohippocampectomy.

OBJECT Analyses of the results of surgery for epilepsy are hindered by inconsistent classifications of seizure outcome, small numbers of patients, and short postoperative follow-up periods. The authors conducted a retrospective study with a reassessment of the long-term seizure outcomes in patients who underwent selective amygdalohippocampectomy (SelAH) for pharmacotherapy-resistant mesial temporal lobe epilepsy (MTLE) at the Zurich University Hospital from 1975 to 1999. METHODS Year-by-year data and the last available data on seizure outcomes were retrospectively assessed for 369 consecutively surgically treated patients who had participated in a follow-up period longer than 1 year as of 1999 and whose outcomes were classified according to the Engel scale and the proposed new International League Against Epilepsy (ILAE) scale. Patients were grouped into nonlesional and lesional MTLE groups depending on whether they harbored a gross anatomical lesion that caused the MTLE. Differentiation was made between curative and palliative operations. Complications related to surgery are reported for 453 patients who underwent SelAH and participated in more than 3 months of follow-up review. The last available outcome data according to the Engel scale were found to be generally similar to those of the new ILAE classification, with 66.9% of patients free from disabling seizures (Engel Class I) compared with 57.1% who were completely seizure and aura free (ILAE Class 1). The last available data on seizure outcome were not significantly different between patients in the lesional and nonlesional MTLE groups. In the lesional group, seizure outcomes were significantly better when patients underwent surgery early in the course of the disease. Overall, 70% of the patients received reductions in their antiepileptic drug treatment at the time of the last available follow-up review. Complications related to the surgical procedures were rare. CONCLUSIONS The authors conclude that SelAH is a safe and effective surgical procedure for MTLE.
Temperature and length scale dependence of hydrophobic effects and their possible implications for protein folding.

The Lum-Chandler-Weeks theory of hydrophobicity [Lum, K. , Chandler, D. & Weeks, J. D. (1999) J. Phys. Chem. 103, 4570-4577] is applied to treat the temperature dependence of hydrophobic solvation in water. The application illustrates how the temperature dependence for hydrophobic surfaces extending less than 1 nm differs significantly from that for surfaces extending more than 1 nm. The latter is the result of water depletion, a collective effect, that appears at length scales of 1 nm and larger. Because of the contrasting behaviors at small and large length scales, hydrophobicity by itself can explain the variable behavior of entropies of protein folding.
Layered shape synthesis: automatic generation of control maps for non-stationary textures

Many inhomogeneous real-world textures are non-stationary and exhibit various large scale patterns that are easily perceived by a human observer. Such textures violate the assumptions underlying most state-of-the-art example-based synthesis methods. Consequently, they cannot be properly reproduced by these methods, unless a suitable control map is provided to guide the synthesis process. Such control maps are typically either user specified or generated by a simulation. In this paper, we present an alternative: a method for automatic example-based generation of control maps, geared at synthesis of natural, highly inhomogeneous textures, such as those resulting from natural aging or weathering processes. Our method is based on the observation that an appropriate control map for many of these textures may be modeled as a superposition of several layers, where the visible parts of each layer are occupied by a more homogeneous texture. Thus, given a decomposition of a texture exemplar into a small number of such layers, we employ a novel example-based shape synthesis algorithm to automatically generate a new set of layers. Our shape synthesis algorithm is designed to preserve both local and global characteristics of the exemplar's layer map. This process results in a new control map, which then may be used to guide the subsequent texture synthesis process.
Latino Parent Involvement: Seeing What Has Always Been There

This study reviews 20 years (1990–2010) of scholarly literature on parent involvement related to Latino parents. Parent involvement behaviors of Latino parents were identified and analyzed according to the dimensions of culture theoretical framework—specifically, the dimension of individualism–collectivism (Hofstede, 1984, 1997; Triandis, 1995; Trumbull, Rothstein, Quiroz, & Greenfield, 2001). From this analysis, categories of involvement for Latino parents emerged, which were then compared to Epstein's typology of parent involvement (1995), a commonly referenced framework adopted by the National Parent Teachers Association. Based on the results of this study of the literature, an expanded framework inclusive of the involvement behaviors of Latino parents was developed. Steps are also discussed for leaders to guide educators in expanding their conceptions of parent involvement.
Postpartum Hemorrhage: Epidemiology, Risk Factors, and Causes

Postpartum hemorrhage (PPH) is a leading cause of death and morbidity relating to pregnancy. Uterine atony is the leading cause of PPH, and trauma, including iatrogenic trauma, increases the risk for postpartum hemorrhage. Women with PPH in a pregnancy are at increased risk of PPH in a subsequent pregnancy. Awareness of these facts, and anticipation and prevention of uterine atony, as well as avoiding unnecessary cesareans, episiotomies, and other genital tract trauma have the potential to significantly reduce the mortality and morbidity from postpartum hemorrhage. The epidemiology of postpartum hemorrhage, including the incidence and temporal trends as well as the causes and risk factors associated with it are presented.