Miracle-dz/UniFAR-FTUs huggingface dataset:
Multigraded Regularity: Syzygies and Fat Points

The Castelnuovo-Mumford regularity of a graded ring is an important invariant in computational commutative algebra, and there is increasing interest in multigraded generalizations. We study connec- tions between two recent definitions of multigraded regularity with a view towards a better understanding of the multigraded Hilbert func- tion of fat point schemes in P n1 ◊ ··· ◊ P nk .
Regime Switches, Agents’ Beliefs, and Post-World War II U.S. Macroeconomic Dynamics

The evolution of inflation and output over the last 50 years is examined through the lens of a micro-founded model that allows for changes in the behavior of the Federal Reserve and in the volatility of structural shocks. Agents are aware of the possibility of regime changes and their beliefs have an impact on the law of motion underlying the macroeconomy. The results support the view that there were regime switches in the conduct of monetary policy. However, the behavior of the Federal Reserve is identified by repeated fluctuations between a Hawk- and a Dove- regime, instead of by the traditional pre- and post- Volcker structure. Counterfactual simulations show that if agents had anticipated the appointment of an extremely conservative Chairman, inflation would not have reached the peaks of the late `70s and the inflation-output trade-off would have been less severe. These "beliefs counterfactuals" are new in the literature. Finally, the paper provides a Bayesian algorithm to handle the technical difficulties that arise in a rational expectations model with Markov-switching regimes.
The Nonlinear Behavior of Unidirectional and Laminated Composites-A Micromechanical Approach

A micromechanics theory for the prediction of the nonlinear behavior of unidirectional fiber-reinforced materials and composite laminates is presented. The method relies on the properties of fibers and matrix, and involves two parameters which describe the nonlinear response of the unreinforced matrix. These two parameters can be backed-out from the nonlinear axial shear response of the unidirectional lamina. The pre dicted behavior of boron/epoxy, glass/epoxy and graphite/polyimide composites is com pared with available measured data, and good agreement is obtained in most cases.
NONRANDOM GENOTYPIC ASSOCIATIONS IN A LEGUME—BRADYRHIZOBIUM MUTUALISM

Genetically divergent lineages often coexist within populations of the annual legume Amphicarpaea bracteata. At one site dominated by two such lineages (termed biotypes “C” and “S”), isolates of root‐nodule bacteria (Bradyrhizobium sp.) were sampled from both hosts and analyzed by enzyme electrophoresis. Symbiont populations on the two plant biotypes were highly distinct. Out of 15 bacterial multilocus genotypes detected (among 51 isolates analyzed), only one was shared in common by the two plant biotypes. Cluster analysis revealed three bacterial lineages (designated I, II, and III), with lineage I found exclusively on biotype C plants, and the two other lineages almost completely restricted to biotype S hosts. Laboratory inoculation tests indicated that lineage I bacteria were strictly specialized on biotype C hosts, forming few or no nodules on plants of the other host biotype. Bacterial lineages II and III were capable of forming nodules on both kinds of plants, but nodule numbers were often significantly higher on biotype S hosts. The nonrandom association between plant and bacterial lineages at this site implies that genetic diversity of hosts is an important factor in the maintenance of polymorphism within the symbiont population.
Maximum Hands-Off Control: A Paradigm of Control Effort Minimization

In this paper, we propose a paradigm of control, called a maximum hands-off control. A hands-off control is defined as a control that has a short support per unit time. The maximum hands-off control is the minimum support (or sparsest) per unit time among all controls that achieve control objectives. For finite horizon continuous-time control, we show the equivalence between the maximum hands-off control and L1-optimal control under a uniqueness assumption called normality. This result rationalizes the use of L1 optimality in computing a maximum hands-off control. The same result is obtained for discrete-time hands-off control. We also propose an L1/L2-optimal control to obtain a smooth hands-off control. Furthermore, we give a self-triggered feedback control algorithm for linear time-invariant systems, which achieves a given sparsity rate and practical stability in the case of plant disturbances. An example is included to illustrate the effectiveness of the proposed control.
Principal Component Regression Analysis of the Relation Between CIELAB Color and Monomeric Anthocyanins in Young Cabernet Sauvignon Wines

Color is one of the key characteristics used to evaluate the sensory quality of red wine, and anthocyanins are the main contributors to color. Monomeric anthocyanins and CIELAB color values were investigated by HPLC-MS and spectrophotometry during fermentation of Cabernet Sauvignon red wine, and principal component regression (PCR), a statistical tool, was used to establish a linkage between the detected anthocyanins and wine coloring. The results showed that 14 monomeric anthocyanins could be identified in wine samples, and all of these anthocyanins were negatively correlated with the L*, b* and H*ab values, but positively correlated with a* and C*ab values. On an equal concentration basis for each detected anthocyanin, cyanidin-3-O-glucoside (Cy3-glu) had the most influence on CIELAB color value, while malvidin 3-O-glucoside (Mv3-glu) had the least. The color values of various monomeric anthocyanins were influenced by their structures, substituents on the B-ring, acyl groups on the glucoside and the molecular steric structure. This work develops a statistical method for evaluating correlation between wine color and monomeric anthocyanins, and also provides a basis for elucidating the effect of intramolecular copigmentation on wine coloring.
Intraoperative Angiography for Cranial Dural Arteriovenous Fistula

BACKGROUND AND PURPOSE: IA is a valuable adjunct during surgery for a variety of neurovascular diseases; however, there are no reported series describing IA for DAVFs. This study was undertaken to evaluate the safety and efficacy of IA for DAVFs. MATERIALS AND METHODS: A retrospective review of DAVF surgical cases during a 20-year period was conducted, and cases with IA were evaluated. Clinical details, surgical and angiographic findings, and postoperative outcomes were reviewed. The incidence of residual fistula on IAs, the utility of the surgical procedure, and the incidence of false-negative findings on IA were also determined. RESULTS: IA was performed in 29 patients (31 DAVFs) for DAVFs. The distribution of the fistulas was the following: transverse-sigmoid (n = 9), tentorial (n = 6), torcular (n = 3), cavernous sinus (n = 4), SSS (n = 4), foramen magnum (n = 3), and temporal-middle fossa (n = 2). Twelve patients had undergone prior embolization, while 6 patients had unsuccessful embolization procedures. Thirty-eight surgeries were performed for DAVF in 29 patients, and IA was performed in 34 surgeries. Forty-four angiographic procedures were performed in the 34 surgeries. Nine patients underwent multiple angiographies. In 11 patients (37.9%), IA revealed residual fistula after the surgeon determined that no lesion remained. This led to further exploration at the same sitting in 10 patients, while in 1 patient, further surgery was performed at a later date. False-negative findings on IA occurred in 3 patients (10.7%). CONCLUSIONS: IA is an important adjunct in surgery for DAVF. In this series, it resulted in further surgical treatment in 37.9% of patients. However, there was a 10% false-negative rate, which justified subsequent postoperative angiography.
Mapping Density Response in Maize: A Direct Approach for Testing Genotype and Treatment Interactions

Maize yield improvement has been strongly linked to improvements in stress tolerance, particularly to increased interplant competition. As a result, modern hybrids are able to produce kernels at high plant population densities. Identification of the genetic factors responsible for density response in maize requires direct testing of interactions between genetic effects and density and evaluation of that response in multiple traits. In this article we take a broad view of the problem and use a general approach based upon mixed models to analyze data from eight segmental inbred lines in a B73 background and their crosses to the unrelated parent Mo17 (hybrids). We directly test for the interaction between treatment effects and genetic effects instead of the commonly used overlaying of results on a common map. Additionally, we demonstrate one way to handle heteroscedasticity of variances common in stress responses. We find that some SILs are consistently different from the recurrent parent regardless of the density, while others differ from the recurrent parent in one density level but not in the other. Thus, we find positive evidence for both main effects and interaction between genetic loci and density in cases where the approach of overlapping results fails to find significant results. Furthermore, our study clearly identifies segments that respond differently to density depending upon the inbreeding level (inbred/hybrid).
Monitoring Presence and Annual Variation of Trichomoniasis in Mourning Doves

Abstract Information about the annual variation of trichomoniasis in mourning doves (Zenaida macroura) may be important in understanding mechanisms affecting mourning dove populations. The objectives of this study were to monitor the presence and annual variation of Trichomonas gallinae for 6 yr in a local mourning dove population using hunter-killed doves. During 1998–2003, 4052 hunter-killed doves were sampled for the presence of T. gallinae; 226 (5.6%) tested positive (4.4%–10.6% range). Results of the monitoring effort were relatively consistent during the 6-yr period, with the presence of T. gallinae being within the range of previously reported estimates for mourning doves. Asymptomatic carriers in one segment of the dove population may provide a mechanism for spreading the disease to other segments of the mourning dove population.
Traveling Salesman Problems with Profits

Traveling salesman problems with profits (TSPs with profits) are a generalization of the traveling salesman problem (TSP), where it is not necessary to visit all vertices. A profit is associated with each vertex. The overall goal is the simultaneous optimization of the collected profit and the travel costs. These two optimization criteria appear either in the objective function or as a constraint. In this paper, a classification of TSPs with profits is proposed, and the existing literature is surveyed. Different classes of applications, modeling approaches, and exact or heuristic solution techniques are identified and compared. Conclusions emphasize the interest of this class of problems, with respect to applications as well as theoretical results.
Combining Multiplex Reverse Transcription-PCR and a Diagnostic Microarray To Detect and Differentiate Enterovirus 71 and Coxsackievirus A16

ABSTRACT Cluster A enteroviruses, including enterovirus 71 (EV71) and coxsackievirus A16 (CA16), are known to cause hand-foot-and-mouth disease (HFMD). Despite the close genetic relationship between these two viruses, EV71 is generally known to be a more perpetuating pathogen involved in severe clinical manifestations and deaths. While the serotyping of enteroviruses is mostly done by conventional immunological methods, many clinical isolates remain unclassifiable due to the limited number of antibodies against enterovirus surface proteins. Array-based assays are able to detect several serotypes with high accuracy. We combined an enterovirus microarray with multiplex reverse transcription-PCR to try to develop a method of sensitively and accurately detecting and differentiating EV71 and CA16. In an effort to design serotype-specific probes for detection of the virus, we first did an elaborate bioinformatic analysis of the sequence database derived from different enterovirus serotypes. We then constructed a microarray using 60-mer degenerate oligonucleotide probes covalently bound to array slides. Using this enterovirus microarray to study 144 clinical specimens from patients infected with HFMD or suspected to have HFMD, we found that it had a diagnostic accuracy of 92.0% for EV71 and 95.8% for CA16. Diagnostic accuracy for other enteroviruses (non-EV71 or -CA16) was 92.0%. All specimens were analyzed in parallel by real-time PCR and subsequently confirmed by neutralization tests. This highly sensitive array-based assay may become a useful alternative in clinical diagnostics of EV71 and CA16.
Section Ii-exercise Physiology & Sports Medicine a Comparison of Physiological Responses to Various Intermittent and Continuous Small-sided Games in Young Soccer Players

Authors submitted their contribution of the article to the editorial board. The purpose of this study was to investigate physiological responses to various intermittent and continuous small-sided games (SSGs) – including 2-aside , 3-aside , and 4-aside games – in young soccer players. Twenty soccer players (average age 16.6±0.5 years; mean body height 176.2±4.6 cm; mean body mass 65.9±5.6 kg) voluntarily participated in this study. The subjects underwent anthropometric measurements followed by the YoYo intermittent recovery test. Then, they played intermittent (SSGint) and continuous (SSGcon) 2-aside , 3-aside , and 4-aside soccer-specific SSGs in random order at 2-day intervals. Paired t-tests were used to assess differences between the training regimens (intermittent and continuous) in terms of heart rate (HR), percentage of maximum HR (%HRmax), and blood lactate concentration (LA). The differences in LA, HR and %HRmax between the 2-aside , 3-aside and 4-aside SSGint or the 2-aside , 3-aside and 4-aside SSGcon were identified using a one-way analysis of variance with repeated measures. The results demonstrated that the 3-aside SSGint and SSGcon measurements were significantly higher than the 2-aside and 4-aside games in terms of HR and %HRmax, whereas the 2-aside SSGint and SSGcon resulted in higher LA responses compared to other SSG types. The study results also demonstrated that SSGint and SSGcon are similar in terms of physiological responses except for 2-aside game LA responses. The results of this study suggest that both SSGint and SSGcon could be used for the physiological adaptations required for soccer specific aerobic endurance.
Adult age-differences in subjective impression of emotional faces are reflected in emotion-related attention and memory tasks

Although younger and older adults appear to attend to and remember emotional faces differently, less is known about age-related differences in the subjective emotional impression (arousal, potency, and valence) of emotional faces and how these differences, in turn, are reflected in age differences in various emotional tasks. In the current study, we used the same facial emotional stimuli (angry and happy faces) in four tasks: emotional rating, attention, categorical perception, and visual short-term memory (VSTM). The aim of this study was to investigate effects of age on the subjective emotional impression of angry and happy faces and to examine whether any age differences were mirrored in measures of emotional behavior (attention, categorical perception, and memory). In addition, regression analyses were used to further study impression-behavior associations. Forty younger adults (range 20–30 years) and thirty-nine older adults (range 65–75 years) participated in the experiment. The emotional rating task showed that older adults perceived less arousal, potency, and valence than younger adults and that the difference was more pronounced for angry than happy faces. Similarly, the results of the attention and memory tasks demonstrated interaction effects between emotion and age, and age differences on these measures were larger for angry than for happy faces. Regression analyses confirmed that in both age groups, higher potency ratings predicted both visual search and VSTM efficiency. Future studies should consider the possibility that age differences in the subjective emotional impression of facial emotional stimuli may explain age differences in attention to and memory of such stimuli.
Postantibiotic effect of the penem FCE 22101 against selected Gram‐positive and Gram‐negative bacteria in vitro and in vivo by the use of a tissue cage model in rabbits

Isolates of Staphylococcus aureus, Streptococcus pneumoniae, Haemophilus influenzae and Klebsiella pneumoniae were tested for their bactericidal activity and postantibiotic effect (PAE) with the new penem FCE 22101. The tissue cage model in rabbits was used to study PAE in vivo. The bactericidal activity against all four species was shown to be in the range of 0.05‐4.0 mg/1. A 99.9% killing effect at MBC concentrations was reached within 2 hours with S. pneumoniae and K. pneumoniae and within 6–8 hours with S. aureus and H. influenzae. After in vitro exposure by FCE 22101 a PAE in vitro and in vivo was obtained against S. aureus, S. pneumoniae and H. influenzae strains but no PAE could be demonstrated against K. pneumoniae. FCE 22101 showed a good bactericidal activity and PAE against the strains investigated, except for K. pneumoniae.
An Open Study with Acamprosate in Belgium and Luxemburg: Results on Sociodemographics, Supportive Treatment and Outcome

This open study on 614 alcohol-dependent patients from 51 centres in Belgium over 24 weeks collected data on the sociodemographic, medical and drug safety profiles and the type of psychosocial support most commonly associated with acamprosate. Psychiatric problems (34%) and gastro-intestinal ulcers (15%) were the most frequent other medical diagnoses. As supportive treatment, 48% of patients received individual psychotherapy, 25% group therapy, 16% relapse prevention and coping skills, 9% brief intervention and 2% family therapy. Fifteen (29%) centres used only 1 form of supportive treatment, 14 (27%) used 2 forms of support, 16 (31%) used 3 forms, 4 (8%) used 4 and only 2 centres (4%) used all 5 supportive treatment options. Three hundred and fifty-nine patients dropped out of the study. At any moment during the treatment period, up to 11% relapsed, 9% had binge drinking and 9% had drinking lapses. The quantity of alcohol consumption during relapse, lapse or binge drinking showed a considerable drop in the mean number of drinks per day, from 19.53 before treatment to 4.23–7.83 drinks for lapse drinking, 9.27–14.62 drinks for binge drinking and 4.96–10.29 drinks per day for relapse. All 8 dimensions of the SF36 quality of life questionnaire improved over the treatment period. Acamprosate was well tolerated by all patients.
Predicate-Argument Structure Analysis with Zero-Anaphora Resolution for Dialogue Systems

This paper presents predicate-argument structure analysis (PASA) for dialogue systems in Japanese. Conventional PASA and semantic role labeling have been applied to newspaper articles. Because pronominalization and ellipses frequently appear in dialogues, we base our PASA on a strategy that simultaneously resolves zero-anaphora and adapt it to dialogues. By incorporating parameter adaptation and automatically acquiring knowledge from large text corpora, we achieve a PASA specialized to dialogues that has higher accuracy than that for newspaper articles.
Metabolism of a Lipid Nanoemulsion Resembling Low-Density Lipoprotein in Patients with Grade III Obesity

INTRODUCTION: Obesity increases triglyceride levels and decreases high-density lipoprotein concentrations in plasma. Artificial emulsions resembling lipidic plasma lipoprotein structures have been used to evaluate low-density lipoprotein metabolism. In grade III obesity, low density lipoprotein metabolism is poorly understood. OBJECTIVE: To evaluate the kinetics with which a cholesterol-rich emulsion (called a low-density emulsion) binds to low-density lipoprotein receptors in a group of patients with grade III obesity by the fractional clearance rate. METHODS: A low-density emulsion was labeled with [14C]-cholesterol ester and [3H]-triglycerides and injected intravenously into ten normolipidemic non-diabetic patients with grade III obesity [body mass index higher than 40 kg/m2] and into ten non-obese healthy controls. Blood samples were collected over 24 hours to determine the plasma decay curve and to calculate the fractional clearance rate. RESULTS: There was no difference regarding plasma levels of total cholesterol or low-density lipoprotein cholesterol between the two groups. The fractional clearance rate of triglycerides was 0.086 ± 0.044 in the obese group and 0.122 ± 0.026 in the controls (p = 0.040), and the fractional clearance rate of cholesterol ester (h−1) was 0.052 ± 0.021 in the obese subjects and 0.058 ± 0.015 (p = 0.971) in the controls. CONCLUSION: Grade III obese subjects exhibited normal low-density lipoprotein removal from plasma as tested by the nanoemulsion method, but triglyceride removal was slower.
UPR decreases CD226 ligand CD155 expression and sensitivity to NK cell‐mediated cytotoxicity in hepatoma cells

NK cells play important roles in anti‐tumor immunity. CD226 is a major NK‐cell activating receptor, which transduces activating signals after binding ligands CD155 and CD112. Here, we demonstrated that activated unfolded protein response (UPR) attenuated the sensitivity of human hepatocellular carcinoma cell (HCC) to NK‐cell cytotoxicity by decreasing the expression level of CD226 ligand CD155 in HCC. The decreased expression level of CD155 was due to the involvement of the activating transcription factor 6 (ATF6) and inositol‐requiring enzyme 1α (IRE1α) pathways. In addition, the IRE1α pathway contributed to the increased expression level of the ER‐associated degradation (ERAD)‐related molecule HRD1 and facilitated the degradation of CD155. Moreover, we found that low levels of CD155 expression were significantly associated with poor prognosis in patients with HCC. Thus, our results provide molecular, cellular, and clinical evidence demonstrating a novel NK cell‐associated immune evasion mechanism, and indicate that targeting this immune evasion pathway may be meaningful in treating patients with HCC.
Controlled Trials of Electroconvulsive Therapy

Electroconvulsive therapy, like every physical treatment in psychiatry with the exception of penicillin for GPI, was introduced on an entirely empirical basis. It became widely adopted before systematic evidence on its efficacy had been collected, and a clinical lore on its indications was built upon a minimal background of objectivity. Slowly a body of evaluation through clinical trials has accumulated, focusing first upon the procedure as a whole and more recently upon the element-the convulsion-that is widely believed to be necessary for the therapeutic effect.