Miracle-dz/UniFAR-FTUs huggingface dataset:
Pre-swirl rotor-stator systems: Flow and heat transfer

This thesis compares previously published heat transfer measurements from a pre-swirl rotor-stator experiment with 3D steady state results from a commercial CFD code. The experimental distribution of Nusselt number on the rotor surface was obtained from a previous study using a scaled model of a gas turbine rotor-stator cavity, where the flow structure was representative of that found in the engine. Computations were carried out using a coupled multigrid RANS solver with a high-Reynolds-number k-ω turbulence model. Previous work has identified three flow parameters governing heat transfer: rotational Reynolds number (Reφ), pre-swirl ratio (βp) and the turbulent flow parameter (λT ). In addition, geometric parameters defining the size and shape of the wheelspace affect the flow structure and therefore the heat transfer characteristic; pre-swirl inlet to receiver hole radius ratio (rp/rb), gap ratio between the discs (G) hub to shroud ratio (a/b), number and size of pre-swirl nozzles and receiver holes. For this study the rotational Reynolds numbers are in the range 0.8 ∗ 10 < Reφ < 1.2 ∗ 10 . The turbulent flow parameter and pre-swirl ratios varied between 0.12 < λT < 0.38 and 0.5 < βp < 2.0, which are comparable to values that occur in industrial gas turbines. At high coolant flow rates, the experiments reveal a peak in heat transfer at the radius of the pre-swirl nozzles, associated with the impingement of the pre-swirl flow. At lower coolant flow rates, the heat transfer is dominated by boundary-layer effects. The Nusselt number on the rotating disc increases as either Reφ or λT increases, and is axisymmetric except in the region of the receiver holes, where significant two-dimensional variations are observed. The computed velocity field is used to explain the heat transfer distributions observed in the experiments. The regions of peak heat transfer around the receiver holes are a consequence of the route taken by the flow. Two routes have been identified: ‘direct’, whereby flow forms a stream-tube between the inlet and outlet; and ‘indirect’, whereby flow mixes with the rotating core of fluid. Both of these regimes are present throughout the spectrum of flow conditions. Two performance parameters have been calculated: the adiabatic effectiveness for the system (Θb,ad) and the discharge coefficient for the receiver holes (Cd,b). Θb,ad increases as βp and λT increase, however an optimum value of βp is found to maximise Cd,b and hence optimise the delivery of coolant to the turbine blades. The effect of the radial location of the inlet nozzles on the performance of the direct-transfer preswirl system is investigated by performing computations for three inlet-to-outlet radius ratios, rp/rb = 0.8, 0.9 and 1.0, a range of pre-swirl ratios, 0.5 < βb < 2.0, and varying
A cooperative MAC providing alternate path for the poor link

We exploit helper-to-helper (h-2-h) cooperation using the broadcast nature of wireless sensor networks. The potential helpers overhear the packet from the transmission of previous hop and the helper transmits the packet in the current hop on behalf of the assigned node (sender). We call it friendship relaying cooperative medium access control (FRC-MAC) protocol. This mechanism eliminates the sender transmission phase, improving the energy efficiency and end-2-end delay. Our innovative proposed MAC protocol provides alternate path when a link is poor temporarily, hence no need to find a new path frequently. In this protocol, each node manages a helper queue in additional to its data queue to store cooperative data so that the helper can transmit cooperative data with higher priority than its own data. We performed a simulation study to investigate network performance and compared with existing protocols. We found that FRC-MAC outperforms existing protocols in terms of end-to-end delay and energy efficiency.
Computing periods of rational integrals

A period of a rational integral is the result of integrating, with respect to one or several variables, a rational function over a closed path. This work focuses particularly on periods depending on a parameter: in this case the period under consideration satisfies a linear differential equation, the Picard-Fuchs equation. I give a reduction algorithm that extends the Griffiths-Dwork reduction and apply it to the computation of Picard-Fuchs equations. The resulting algorithm is elementary and has been successfully applied to problems that were previously out of reach.
Patterns of preserved and impaired spatial memory in a case of developmental amnesia

The hippocampus is believed to have evolved to support allocentric spatial representations of environments as well as the details of personal episodes that occur within them, whereas other brain structures are believed to support complementary egocentric spatial representations. Studies of patients with adult-onset lesions lend support to these distinctions for newly encountered places but suggest that with time and/or experience, schematic aspects of environments can exist independent of the hippocampus. Less clear is the quality of spatial memories acquired in individuals with impaired episodic memory in the context of a hippocampal system that did not develop normally. Here we describe a detailed investigation of the integrity of spatial representations of environments navigated repeatedly over many years in the rare case of H.C. , a person with congenital absence of the mammillary bodies and abnormal hippocampal and fornix development. H.C. and controls who had extensive experience navigating the residential and downtown areas known to H.C. were tested on mental navigation tasks that assess the identity, location, and spatial relations among landmarks, and the ability to represent routes. H.C. was able to represent distances and directions between familiar landmarks and provide accurate, though inefficient, route descriptions. However, difficulties producing detailed spatial features on maps and accurately ordering more than two landmarks that are in close proximity to one another along a route suggest a spatial representation that includes only coarse, schematic information that lacks coherence and that cannot be used flexibly. This pattern of performance is considered in the context of other areas of preservation and impairment exhibited by H.C. and suggests that the allocentric-egocentric dichotomy with respect to hippocampal and extended hippocampal system function may need to be reconsidered.
Molecular and cellular effects of azilsartan: a new generation angiotensin II receptor blocker

Background Azilsartan medoxomil is a newly approved angiotensin receptor blocker (ARB) reported to lower 24-h blood pressure more effectively than maximally recommended doses of older ARBs. Although azilsartan is considered to be an unusually potent angiotensin II type 1 (AT1) receptor antagonist, little is known about the potential pleiotropic effects of this molecule. Methods and results We investigated pleiotropic features of azilsartan in cell-based assay systems independent of its effects on blood pressure. In cultured 3T3-L1 preadipocytes, azilsartan enhanced adipogenesis and exerted greater effects than valsartan on expression of genes encoding peroxisome proliferator-activated receptor-&agr; (PPAR&agr;), PPAR&dgr;, leptin, adipsin, and adiponectin. The effects of azilsartan on adipocyte differentiation and gene expression were observed at concentrations of azilsartan that did not classically stimulate PPAR activity in cell-based transactivation assays. Azilsartan also potently inhibited vascular cell proliferation in the absence of exogenously supplemented angiotensin II. In aortic endothelial cells, azilsartan inhibited cell proliferation at concentrations as low as 1 &mgr;mol/l, whereas valsartan showed little or no antiproliferative effects at concentrations below 10 &mgr;mol/l. Antiproliferative effects of azilsartan were also observed in cells lacking AT1 receptors. In addition, azilsartan, but not valsartan, blocked angiotensin II-induced activation of mitogen-activated protein kinase in vascular smooth muscle cells 4–8 h after washout of drug from the incubation media. Conclusion These findings suggest that azilsartan can function as a pleiotropic ARB with potentially beneficial effects on cellular mechanisms of cardiometabolic disease through actions that could involve more than just blockade of AT1 receptors and/or reduction in blood pressure.
Expression of Rattus norvegicus mtDNA inMus musculus Cells Results in Multiple Respiratory Chain Defects*

The production of in vitro andin vivo models of mitochondrial DNA (mtDNA) defects is currently limited by a lack of characterized mouse cell mtDNA mutants that may be expected to model human mitochondrial diseases. Here we describe the creation of transmitochondrial mouse (Mus musculus) cells repopulated with mtDNA from different murid species (xenomitochondrial cybrids). The closely related Mus spretus mtDNA is readily maintained when introduced into M. musculus mtDNA-less (ρ0) cells, and the resulting cybrids have normal oxidative phosphorylation (OXPHOS). When the more distantly related Rattus norvegicus mtDNA is transferred to the mouse nuclear background the mtDNA is replicated, transcribed, and translated efficiently. However, function of several OXPHOS complexes that depend on the coordinated assembly of nuclear and mtDNA-encoded proteins is impaired. Complex I activity in the Rattusxenocybrid was 46% of the control mean; complex III was 37%, and complex IV was 78%. These defects combined to restrict maximal respiration to 12–31% of the control and M. spretusxenocybrids, as measured polarographically using isolated cybrid mitochondria. These defects are distinct to those previously reported for human/primate xenocybrids. It should be possible to produce other mouse xenocybrid constructs with less severe OXPHOS phenotypes, to model human mtDNA diseases.
Sexual offender recidivism revisited: a meta-analysis of recent treatment studies.

Meta-analyses were performed on 12 studies of treatment with sexual offenders (N = 1,313). A small, but robust, overall effect size was found for treatment versus comparison conditions (r = .12). The overall recidivism rate for treated sexual offenders was . 19 versus . 27 for untreated sexual offenders. Treatment effect sizes across studies, however, were heterogeneous. Effect sizes were larger in studies that had higher base rates of recidivism, had follow-up periods longer than 5 years, included outpatients, and involved cognitive-behavioral or hormonal treatments. Cognitive-behavioral (p < .0005) and hormonal treatments (p < .00005) were significantly more effective than behavioral treatments but were not significantly different from each other.
Generalized Sampled-Data Stabilization of Well-Posed Linear Infinite-Dimensional Systems

We consider well-posed linear infinite-dimensional systems, the outputs of which are sampled in a generalized sense using a suitable weighting function. Under certain natural assump- tions on the system, the weighting function, and the sampling period, we show that there exists a generalized hold function such that unity sampled-data feedback renders the closed-loop system exponentially stable (in the state-space sense) as well as L 2 -stable (in the input-output sense). To illustrate our main result, we describe an application to a structurally damped Euler-Bernoulli beam.
Deictic Reference and Discourse Structure

Research on the factors and processes involved in pronoun interpretation has to date concentrated on anaphoric pronouns. Results have supported the now widely-held view that discourse understanding involves the creation of a partial, mental model of the situation described through the discourse. Anaphoric pronouns are taken to refer to elements of that model (often called discourse referents or discourse entities), usually ones that have, at the moment of referring, some special focus status. This paper examines deictic pronouns in particular, ones that refer to the interpretation of one or more clauses. I argue that referents for these pronouns must come from the interpretations of discourse segments on the right frontier of an evolving structure representing the discourse. Under the assumption that reference is always to an individual, this implies that discourse segment interpretations must also be part of the evolving discourse model. I discuss this in the last section of the paper. Comments University of Pennsylvania Department of Computer and Information Science Technical Report No. MSCIS-89-55. This technical report is available at ScholarlyCommons: http://repository.upenn. edu/cis_reports/848 Deictic Reference And Discourse Structure MS-CIS-89-55 LINC LAB 159
Interleukin‐10 gene promoter polymorphism in Polish rheumatoid arthritis patients

Interleukin (IL)‐10 is an important multifunctional cytokine with both anti‐inflammatory and immunoregulatory effects in rheumatoid arthritis (RA). In the present study, we evaluated the frequency and potential impact of IL‐10 promoter polymorphisms on susceptibility to and severity of RA in Polish in – patients with a high disease activity (mean DAS 28 C‐reactive protein 5.25). DNA was obtained from 244 RA patients and 106 healthy controls. The −592C/A and −1082G/A IL‐10 gene polymorphisms were amplified by polymerase chain reaction with restriction endonuclease mapping. The frequency of the IL‐10‐592CA, ‐592AA genotypes (respectively: 30% vs 5% and 7% vs 0%) and allele −592A (37% vs 5%) were significantly higher in RA patients as compared with a control group. We did not find any association of the IL‐10‐592C/A genotype distribution with disease parameters, except for an increased ESR (erythrocyte sedimentation rate) in patients with the −592CC genotype as compared with those with −592CA or −592AA genotypes (P = 0.01). The frequency of the IL‐10‐1082GG genotype was lower (P = 0.0001), and that of the IL‐10‐1082GA genotype was higher (P = 0.009) in RA patients comparing with the control group. In RA patients with −1082GA or −1082AA genotypes the time duration of the disease (P = 0.03), Health Assessment Questionnaire (HAQ) Score (P = 0.04) and PLT count (P = 0.001) were significantly increased as compared with subjects with −1082GG genotype. Presented findings indicate that IL‐10‐592C/A and IL‐10‐1082G/A polymorphisms may be considered genetic risk factors for RA susceptibility and severity.
What do you bring to the table?: investigations of a collaborative workspace

Collaborative spaces supporting personal mobile devices provide for a powerful integration of personalized content with supportive embedded infrastructure. Social, spatial, and informational considerations have a salient impact on such modern collaborative spaces. The design, implementation, and evaluation of a collaborative workspace prototype that directly supports the integrated use of mobile devices not only yields insights into the basic capabilities behind such a space, but also a deeper understanding of the different composition control mechanisms available. Specifically, such environments can effectively work with existing laptop platforms, and show increased promise for supporting future generations of smaller mobile devices.
School-Based Approaches to Drug Abuse Prevention : Evidence for Effectiveness and Suggestions for Determining Cost-Effectiveness

Considerable effort has been expended over the past two decades to understand the causes of drug abuse and to identify effective prevention strategies. Much of this work has taken place in school settings, mainly because schools provide easy access to large numbers of individuals judged to be the primary target population for prevention efforts. They also provide a reasonably suitable environment for conducting prevention research studies. Despite their traditional educational mission, schools have been increasingly directed by State and local governments to assume responsibility for addressing an array of social and health problems. While not enthusiastic about mandates that some may see as distracting schools from their primary mission, many educators have a growing recognition that problems such as drug abuse are a significant barrier to achieving basic educational objectives. On a Federal level, for example, the U.S. Department of Education has included drug-free and safe schools as one of its goals for improving the quality of education in this country.
Share to Win: Unraveling Information Sharing in Dynamic Coalitions

Information sharing is increasingly recognized as the most essential requirement for success in modern military and civil-military coalitions. Coalition operations consist of information systems characterized by highly dynamic and information rich environments, large varieties of information technologies deployed, and great diversities of individuals involved. Although all of these individuals have to ’share to win’, extensive information sharing still appears to be the exception rather than the rule. Individuals tend to hoard information for various reasons. Extant research explored individual information sharing behaviour and the use of information technologies for sharing from various perspectives. This paper emphasizes the need for a multidimensional conceptualization of individual information sharing behaviour by integrating different perspectives. I argue that an individual’s decision to engage in information sharing is determined jointly by a cognitive, a social-psychological, and a technological dimension, and label these dimensions Identification, Inter-relation, and Interchange, respectively. I employ two multiple qualitative case studies involving data from realworld information sharing drawn from the military domain to develop a multidimensional model for the assessment of individual information sharing behaviour. The proposed model enables a systematic identification of this highly complex and challenging process. This identification is a first step in assessing the multifaceted phenomenon of information sharing in complex socio-technical systems. Implications for theory and practice are discussed, and future research directions are proposed.
Haemodiafiltration: not effective or cost-effective compared with haemodialysis.

cathepsins in heart disease: focus on biology and mechanisms with clinical implication. Circulation 2012; 125: 1551–1562 17. Virtue S, Vidal-Puig A. Adipose tissue expandability, lipotoxicity and the metabolic syndrome—an allostatic perspective. Biochim Biophys Acta 2010; 1801: 338–349 18. Naour N, Fellahi S, Renucci JF et al. Potential contribution of adipose tissue to elevated serum cystatin C in human obesity. Obesity (Silver Spring) 2009; 17: 2121–2126 19. Ruggenenti P, Porrini EL, Gaspari F et al. Glomerular hyperfiltration and renal disease progression in type 2 diabetes. Diabetes Care 2012; 35: 2061–2068 20. Perkins BA, Nelson RG, Ostrander BEP et al. Detection of renal function decline in patients with diabetes and normal or elevated GFR by serial measurements of serum cystatin C concentration: results of a 4-year follow-up study. J Am Soc Nephrol 2005; 16: 1404–1412
Ambulatory Estimation of Relative Foot Positions by Fusing Ultrasound and Inertial Sensor Data

Relative foot position estimation is important for rehabilitation, sports training and functional diagnostics. In this paper an extended Kalman filter fusing ultrasound range estimates and inertial sensors is described. With this filter several gait parameters can be estimated ambulatory. Step lengths and stride widths from 54 walking trials of three healthy subjects were estimated and compared to an optical reference. Mean ( ± standard deviation) of absolute difference was 1.7 cm ( ±1.8 cm) and 1.2 cm ( ±1.2 cm) for step length and stride width respectively. Walking with a turn and walking around in a square area were also investigated and resulted in mean absolute differences of 1.7 cm ( ±2.0 cm) and 1.5 cm ( ±1.5 cm) for step lengths and stride widths. In addition to these relative positions, velocities, orientations and stance and swing times can also be estimated. We conclude that the presented system is low-cost and provides a complete description of footstep kinematics and timing.
C. elegans Anillin proteins regulate intercellular bridge stability and germline syncytial organization

The Rockefeller University Press $30.00 J. Cell Biol. Vol. 206 No. 1 129–143 www.jcb. org/cgi/doi/10.1083/jcb.201310117 JCB 129 Correspondence to Nicolas T. Chartier: chartier.nico@gmail.com; or JeanClaude Labbé: jc.labbe@umontreal.ca A.S. Maddox’s present address is Dept. of Biology, The University of North Carolina at Chapel Hill, 408 Fordham Hall, Chapel Hill, NC, 27599. N.T. Chartier’s present address is INSERM U823, Université Joseph FourierGrenoble 1, Institut Albert Bonniot, Grenoble F-38700, France. Abbreviation used in this paper: NMY-2, nonmuscle myosin I
OF THE EXPERIMENTAL ANALYSIS OF BEHAVIOR DIFFERENTIAL REINFORCEMENT AND STIMULUS CONTROL OF NOT RESPONDING '

Pigeons were trained to respond with equal variable-interval reinforcement in the presence of a white key and also a white key with a vertical line. They were then trained not to respond to the vertical line by extinguishing the response or by reinforcing its non-occurrence at various frequencies. During training, the rate of key-pecking in the presence of the white key, maintained by a constant variable-interval schedule of reinforcement, depended on the frequency of reinforcement in the presence of the line. When lines of different orientations were presented in a generalization test, birds trained with extinction responded more to other orientations than to the vertical line, whereas those trained with high frequencies of reinforcement for not responding tended to respond equally at all line orientations. Intermediate frequencies of reinforcement gave mixed results.
A Code for Behavioral Inhibition on the Basis of Color, But Not Motion, in Ventrolateral Prefrontal Cortex of Macaque Monkey

To examine the neural mechanism for behavioral inhibition, we recorded single-cell activity in macaque ventrolateral prefrontal cortex, which is known to receive visual information directly from the inferotemporal cortex. In response to a moving random pattern of colored dots, monkeys had to make a go or no-go response. In the color condition, green indicated go, whereas red indicated no-go, regardless of the motion direction; in the motion condition, upward indicated go, whereas downward indicated no-go, regardless of the color. Approximately one-half of the visual cells were go/no-go differential. A majority of these cells (64/73) showed differential activity only in the color condition; they responded nondifferentially in the motion condition, although the same set of stimuli was used. We classified these cells as “go type” (n = 41) and “no-go type” (n = 23) depending on the color for which they showed a stronger response. Interestingly, in both types of cells, the differential effects were observed only for the no-go-indicating color. Compared with the nondifferential responses in the motion condition, go-type cells in the color condition showed weaker responses to the no-go-indicating color, whereas their responses to the go-indicating color were similar; in contrast, no-go type cells showed stronger responses to the no-go-indicating color, whereas their responses to the go-indicating color were similar. Both types of cells did not show any activity change during the actual execution of the go or no-go response. These results suggest that neurons in ventrolateral prefrontal cortex contribute to stimulus–response association in complex task situations by inhibiting behavioral responses on the basis of visual information from the ventral stream.