Miracle-dz/UniFAR-FTUs huggingface dataset:
Household and State-istics: Cornerstones of Society in Population Censuses (Belgium, 1846–1947)

Statistics originally meant state-istics, a scientific representation of the state for governmental purposes. It did not just cover the growing need for information in the emerging nation-states, but also contributed to establishing a new idea of government. This paper analyzes the rearticulation of the household within modern state-istics. The Belgian population censuses, which were first organized by Adolphe Quetelet, provide the material for our analyses. More particularly, we focus on the period from the mid-nineteenth until the mid-twentieth century, when the welfare state started to develop alternatives to household dependence. We discuss how the orientation shifted from the de facto to the de jure population; the state became involved in redefining the conditions for household membership. Two types of co-residential units were distinguished: family household and collective household. But inmates of collective households caused much concern; statisticians tried to reassign them administratively to households considered more appropriate. We also discuss the articulation of intrahousehold relations. Changes in the notion of “belongingness” show how the state articulated its expectations regarding the proverbial cornerstones of society.
Impacts of lesion severity and tyrosine kinase receptor B deficiency on functional outcome of femoral nerve injury assessed by a novel single‐frame motion analysis in mice

Functional recovery after peripheral nerve injury is often poor. Comprehension of cellular and molecular mechanisms limiting or promoting restoration of function and design of efficient therapeutic approaches remain serious challenges for neuroscience and medicine. Progress has been restricted by the lack of reliable methods for evaluation of motor functions in laboratory animals. We describe a novel approach for assessment of muscle function in mice after femoral nerve damage, an injury causing impairment of knee extension. The functional deficit can be precisely estimated by angle and distance measurements on single video frames recorded during movements of the animals with or without body weight support. Using this method we describe here the precise time‐course and degree of functional recovery after femoral nerve crush and transection. In addition, we show that restoration of function is considerably impaired in mice with a reduced expression level of the tyrosine kinase receptor B, a cognate receptor for the neurotrophin brain‐derived neurotrophic factor. This finding is consistent with known functions of brain‐derived neurotrophic factor and tyrosine kinase receptor B and demonstrates the potential of the method. The principles of the approach are highly relevant for the development of novel functional assays in other peripheral and, in particular, central nervous system injury paradigms.
Administration of PLK-1 small interfering RNA with atelocollagen prevents the growth of liver metastases of lung cancer

Liver metastasis is one of the most important prognostic factors in lung cancer patients. However, current therapies are not sufficient. RNA interference provides us a powerful and promising approach for treating human diseases including cancers. Herein, we investigated the in vitro effects of PLK-1 small interfering RNA (siRNA) on human lung cancer cell lines and the in vivo usage of PLK-1 siRNA with atelocollagen as a drug delivery system in a murine liver metastasis model of lung cancer. PLK-1 was overexpressed in cell lines and in cancerous tissues from lung cancer patients. PLK-1 siRNA treatment inhibited growth and induced apoptosis in a concentration-dependent manner. To verify in vivo efficacy, we confirmed that atelocollagen was a useful drug delivery system in our model of implanted luciferase-labeled A549LUC cells by detecting reduced bioluminescence after an i.v. injection of luciferase GL3 siRNA/atelocollagen. PLK-1 siRNA/atelocollagen was also successfully transfected into cells and inhibited the progression of metastases. This study shows the efficacy of i.v. administration of PLK-1 siRNA/atelocollagen for liver metastases of lung cancer. We believe siRNA therapy will be a powerful and promising strategy against advanced lung cancer. [Mol Cancer Ther 2008;7(9):2904–12]
Untranslated Element in Neurofilament mRNA Has Neuropathic Effect on Motor Neurons of Transgenic Mice

Studies of experimental motor neuron degeneration attributable to expression of neurofilament light chain (NF-L) transgenes have raised the possibility that the neuropathic effects result from overexpression of NF-L mRNA, independent of NF-L protein effects (Cañete-Soler et al., 1999). The present study was undertaken to test for an RNA-mediated pathogenesis. Transgenic mice were derived using either an enhanced green fluorescent protein reporter construct or modified chimeric constructs that differ only in their 3′ untranslated regions (UTRs). Motor function and spinal cord histology were normal in mice expressing the unmodified reporter transgene. In mice expressing a chimeric transgene in which sequence of NF-L 3′ UTR was inserted into the 3′ UTR of the reporter transgene, we observed growth retardation and reduced kinetic activity during postnatal development. Older mice developed impairment of motor function and atrophy of nerve fibers in the ventral roots. A similar but more severe phenotype was observed when the chimeric transgene contained a 36 bp c-myc insert in an mRNA destabilizing element of the NF-L sequence. Our results suggest that neuropathic effects of overexpressing NF-L can occur at the level of transgene RNA and are mediated by sequences in the NF-L 3′ UTR.
Results of a User Survey to Determine Needs for a Health Sciences Library Renovation

The Health Sciences Library (HSL) at the University of Calgary serves the faculties of Medicine, Veterinary Medicine, and Nursing, and is the library for the staff, physicians, and patients of the Foothills Hospital. In August 2008, HSL was approached by the Faculty of Medicine requesting a significant portion of library space to accommodate an increase in undergraduate medical student enrollment. Despite initial concerns that the reduction of library space would be detrimental to all clients, the proposed changes actually benefited both parties involved. The Faculty of Medicine needed a lecture theatre, two 50-seat classrooms, and six small group rooms; whereas the library required a renovation to better accommodate the technological demands of current students and to provide a new learning-conducive environment for future generations of students, faculty, healthcare providers, and patients. To ensure that the HSL renovation met the needs of our clients, a brief opinion survey of five open-ended questions was designed and administered via electronic mail to all staff, students, and faculty served by HSL. In all, 170 survey responses were received. While comments made supported key themes discovered from the literature, they also provided HSL with a new perspective, resulting in design changes to better meet clients' needs.
Retinaldehyde dehydrogenase 2 (RALDH2)-mediated retinoic acid synthesis regulates early mouse embryonic forebrain development by controlling FGF and sonic hedgehog signaling

Although retinoic acid (RA) has been implicated as one of the diffusible signals regulating forebrain development, patterning of the forebrain has not been analyzed in detail in knockout mouse mutants deficient in embryonic RA synthesis. We show that the retinaldehyde dehydrogenase 2 (RALDH2) enzyme is responsible for RA synthesis in the mouse craniofacial region and forebrain between the 8- and 15-somite stages. Raldh2-/- knockout embryos exhibit defective morphogenesis of various forebrain derivatives, including the ventral diencephalon, the optic and telencephalic vesicles. These defects are preceded by regionally decreased cell proliferation in the neuroepithelium, correlating with abnormally low D-cyclin gene expression. Increases in cell death also contribute to the morphological deficiencies at later stages. Molecular analyses reveal abnormally low levels of FGF signaling in the craniofacial region, and impaired sonic hedgehog signaling in the ventral diencephalon. Expression levels of several regulators of diencephalic, telencephalic and optic development therefore cannot be maintained. These results unveil crucial roles of RA during early mouse forebrain development, which may involve the regulation of the expansion of neural progenitor cells through a crosstalk with FGF and sonic hedgehog signaling pathways.
Objective evaluation of plantar hyperhidrosis after sympathectomy

OBJECTIVE: The aim of the present study was to prospectively, randomly, blindly, and objectively investigate how surgery affects plantar sudoresis in patients with palmar and plantar hyperhidrosis over a one-year period using a sudorometer (VapoMeter). METHODS: From February 2007 to May 2009, 40 consecutive patients with combined palmar hyperhidrosis and plantar hyperhidrosis underwent video-assisted thoracic sympathectomy at the T3 or T4 ganglion level (15 women and 25 men, with a mean age of 25 years). RESULTS: Immediately after the operation and during the one-year follow-up, all of the patients were free from palmar hyperhidrosis episodes. Compensatory hyperhidrosis of varying degrees was observed in 35 (87.5%) patients after one year. Only two (2.5%) patients suffered from severe compensatory hyperhidrosis. There was a large initial improvement in plantar hyperhidrosis in 46.25% of the cases, followed by a progressive regression of that improvement, such that only 30% continued to show this improvement after one year. The proportion of patients whose condition worsened increased progressively (from 21.25% to 47.50%), and the proportion of stable patients decreased (32.5% to 22.50%). This was not related to resection level; however, a lower intensity of plantar hyperhidrosis prior to sympathectomy correlated with worse evolution. CONCLUSION: Patients with palmar hyperhidrosis and plantar hyperhidrosis who underwent video-assisted thoracic sympathectomy to treat their palmar hyperhidrosis exhibited good initial improvement in plantar hyperhidrosis, which then decreased to lesser degrees of improvement over a one-year period following the surgery. For this reason, video-assisted thoracic sympathectomy should not be performed when only plantar hyperhidrosis is present.
Ecological Effects of Prescribed Fire Season: A Literature Review and Synthesis for Managers

Prescribed burning may be conducted at times of the year when fires were infrequent historically, leading to concerns about potential adverse effects on vegetation and wildlife. Historical and prescribed fire regimes for different regions in the continental United States were compared and literature on season of prescribed burning synthesized. In regions and vegetation types where considerable differences in fuel consumption exist among burning seasons, the effects of prescribed fire season appears, for many ecological variables, to be driven more by fire-intensity differences among seasons than by phenology or growth stage of organisms at the time of fire. Where fuel consumption differs little among burning seasons, the effect of phenology or growth stage of organisms is often more apparent, presumably because it is not overwhelmed by fire-intensity differences. Most species in ecosystems that evolved with fire appear to be resilient to one or few out-of-season prescribed burn(s). However, a variable fire regime including prescribed burns at different times of the year may alleviate the potential for undesired changes and maximize biodiversity.
Investigating Learning Approaches of Confucian Heritage Culture Students and Teachers’ Perspectives in Hong Kong

The study presents a comparison between the learning approaches of first and final year students, supplemented with the teachers’ perspective at a university in Hong Kong. The study examines the learning approaches of Confucian heritage culture students and the teachers’ perspective in the context of outcome-based curricula. The results indicate that a higher proportion of final year students pursue surface learning goals than first year students. Nevertheless, the vast majority of first and final year students embrace a deep approach to learning. This is in stark contrast to the teachers’ perspective because they believe that the students generally adopt a surface approach to learning. Steps to an interactive and positive learning environment to effectively respond to outcome-based learning are provided.
Producing sons reduces lifetime reproductive success of subsequent offspring in pre-industrial Finns

Life-history theory states that reproductive events confer costs upon mothers. Many studies have shown that reproduction causes a decline in maternal condition, survival or success in subsequent reproductive events. However, little attention has been given to the prospect of reproductive costs being passed onto subsequent offspring, despite the fact that parental fitness is a function of the reproductive success of progeny. Here we use pedigree data from a pre-industrial human population to compare offspring life-history traits and lifetime reproductive success (LRS) according to the cost incurred by each individual's mother in the previous reproductive event. Because producing a son versus a daughter has been associated with greater maternal reproductive cost, we hypothesize that individuals born to mothers who previously produced sons will display compromised survival and/or LRS, when compared with those produced following daughters. Controlling for confounding factors such as socio-economic status and ecological conditions, we show that those offspring born after elder brothers have similar survival but lower LRS compared with those born after elder sisters. Our results demonstrate a maternal cost of reproduction manifested in reduced LRS of subsequent offspring. To our knowledge, this is the first time such a long-term intergenerational cost has been shown in a mammal species.
Vygotsky and education: The development of scientific concepts and discourse

Vygotsky's writings on the development of scientific concepts have important implications for both psychology and education. Although his writing on scientific concepts has not been followed by as much research as some of his other ideas, it constitutes an important part of a central theme in his overall theory. For Vygotsky, the study of cognitive development included investigating the effect of formal school instruction on the development of thinking; he saw instruction as fundamentally different from spontaneous learning in everyday contexts, and he theorized that such experience would have a distinctive and transforming impact on the school child's mental development. In Vygotsky's view, the structure of school learning provides the kind of cultural experience in which the higher psychological processes, such as voluntary attention and logical memory, are formed. Thus the distinction between spontaneous or everyday concepts and scientific concepts is central to a Vygotskian analysis. A spontaneous concept is purely denotative in the sense of being defined in terms of perceptual or functional or contextual properties of its referent. In contrast, “the relationship [of a scientific concept] to an object is mediated from the start by some other concept. … the very notion of scientific concept implies a certain position in relation to other concepts, i.e., a place within a system of concepts ” (1962, p. 93, italics added). The development of a system of concepts and the mediation of these concepts are seen as involving a kind of learning from which higher psychological functions develop.
Genetic and metabolic analysis of the first adult with congenital disorder of glycosylation type Ib: long-term outcome and effects of mannose supplementation.

We report the diagnosis and follow-up of two sibs reported in 1980 with recurrent venous thromboses and protein-losing enteropathy; one sib with biopsy-proven hepatic fibrosis died at age 5. The combination of symptoms was suggestive of the recently characterized congenital disorder of glycosylation type Ib (CDG-Ib), which is caused by a deficiency of the enzyme phosphomannose isomerase (PMI). An abnormal serum transferrin isoelectric focusing (IEF) pattern and a reduced PMI activity confirmed the diagnosis of CDG-Ib. Furthermore, mutational analysis of the MPI gene revealed two missense mutations, 419 T --> C (I140T) and 636 G --> A (R219Q), a single base substitution in intron 5, 670 + 9G --> A, as well as a polymorphism 1131A --> C (V377V) in both sibs. The surviving 33-year-old sib has had no further symptoms following childhood. Short-term low-dose oral mannose supplementation improved her transferrin IEF pattern and normalized her antithrombin III activity, further substantiating the beneficial effect of mannose in CDG-Ib. When her mannose blood level was measured, she showed a lower steady-state level but a faster mannose clearance rate. These results suggest that the clinical manifestations of PMI deficiency, although serious in childhood, can improve with age, even without mannose therapy, and allow for a normal adult life. However, the long-term prognosis may vary from patient to patient.
Combinatorial aspects of matrix models

We show that under reasonably general assumptions, the rst order asymptotics of the free energy of matrix models are generating functions for colored planar maps. This is based on the fact that solutions of the Schwinger-Dyson equations are, by nature, generating functions for enumerating planar maps, a remark which bypasses the use of Gaussian calculus.
Phonological awareness and vocabulary performance of monolingual and bilingual preschool children with hearing loss

This pilot study compared the phonological awareness skills and vocabulary performance of English monolingual and Spanish–English bilingual children with and without hearing loss. Preschool children with varying degrees of hearing loss (n = 18) and preschool children without hearing loss (n = 19) completed measures of phonological awareness and receptive and expressive vocabulary knowledge. On phonological awareness tasks, the performance of bilingual children with hearing loss was significantly higher than bilingual children with normal hearing, but not higher than either monolingual group of children. On norm-referenced vocabulary knowledge measures, the performance of monolingual and bilingual children with hearing loss was significantly lower than monolingual and bilingual children with normal hearing. Correlations for phonological awareness and vocabulary knowledge were found for both groups of children with normal hearing, but not children with hearing loss. This study represents preliminary evidence that children with hearing loss may develop phonological awareness differently than children with normal hearing and that language and educational experience are critical to understanding the phonological awareness performance in children with hearing loss.
Initial Genetic Characterization of the 1918 “Spanish” Influenza Virus

The “Spanish” influenza pandemic killed at least 20 million people in 1918–1919, making it the worst infectious pandemic in history. Understanding the origins of the 1918 virus and the basis for its exceptional virulence may aid in the prediction of future influenza pandemics. RNA from a victim of the 1918 pandemic was isolated from a formalin-fixed, paraffin-embedded, lung tissue sample. Nine fragments of viral RNA were sequenced from the coding regions of hemagglutinin, neuraminidase, nucleoprotein, matrix protein 1, and matrix protein 2. The sequences are consistent with a novel H1N1 influenza A virus that belongs to the subgroup of strains that infect humans and swine, not the avian subgroup.
Relationship of SOC with sociodemographic variables, mental disorders and mortality

Background: SOC is associated with wellbeing and health. The Lundby Study is a cohort study of an unselected population (n=3563) in whom mental health and personality traits have been assessed since 1947, with follow ups in 1957, 1972, and 1997. Aim: To describe the relationship of Antonovsky’s 29-item sense of coherence scale (SOC) and its three subscales (comprehensibility, manageability, and meaningfulness) to mental health and mortality in an unselected middle-aged and elderly community cohort, controlling for gender, age, marital status, and socioeconomic status. Another aim was to analyse the three-factor structure of the SOC. Methods: Of the 1797 surviving subjects in 1997, 1559 participated in a semistructured diagnostic interview, and 1164 subjects completed the SOC questionnaire. Psychiatrists performed diagnostic evaluations. Collateral information was obtained from case notes and registers. Dates of death from 1997–2011 were obtained from the cause of death register. Results: SOC scores showed no sex differences, but were positively correlated with age. SOC scores were higher in married relative to unmarried participants and in blue-collar workers and self-employed individuals relative to white-collar workers. Total SOC and subscale scores were negatively correlated with depressive, anxiety, organic, and psychotic disorders. Male gender was positively correlated with comprehensibility and female gender was positively correlated with manageability and meaningfulness. Higher comprehensibility scores were correlated with lower mortality. Conclusions: SOC scores increased with age, were higher for blue-collar workers, and were lower for individuals with psychiatric disorders. Higher comprehensibility scores were associated with lower mortality. However, there was only weak evidence for a three-factor structure.
Performability Models for Multi-Server Systems with High-Variance Repair Durations

We consider cluster systems with multiple nodes where each server is prone to run tasks at a degraded level of service due to some software or hardware fault. The cluster serves tasks generated by remote clients, which are potentially queued at a dispatcher. We present an analytic queueing model of such systems, represented as an M/MMPP/1 queue, and derive and analyze exact numerical solutions for the mean and tail-probabilities of the queue-length distribution. The analysis shows that the distribution of the repair time is critical for these performability metrics. Additionally, in the case of high-variance repair times, the model reveals so-called blow-up points, at which the performance characteristics change dramatically. Since this blowup behavior is sensitive to a change in model parameters, it is critical for system designers to be aware of the conditions under which it occurs. Finally, we present simulation results that demonstrate the robustness of this qualitative blow-up behavior towards several model variations.
Push and Pull Motivations for Quitting

We report a new analysis of data from a multi-year study, some of which were previously published in the current journal. A longitudinal sample of 380 computer specialists was followed over two years, yielding three measures each of job satisfaction, organizational commitment, and turnover intentions, as well as actual turnover, and reasons for leaving, at Times 2 and 3. Career paths were more diverse than the classical distinction between stayers and leavers implies. Furthermore, although the largest single group of leavers cited “push” reasons, conforming to the classical withdrawal model, a sizable number were attracted to another job (“pull motivation”). In a three-wave structural equation model, job (dis)satisfaction predicted turnover, while organizational commitment exerted its influence only via its association with job satisfaction. As expected, however, attitudes predicted turnover only for participants with push motivation. Quitting, in turn, predicted an improvement in both satisfaction and co.