Miracle-dz/UniFAR-FTUs huggingface dataset:
Basic Symptoms, Temperament and Character in Adolescent Psychiatric Disorders

Objective: Basic symptoms are early subtle changes in thinking, feeling and perception that are subjectively experienced and precede the onset of a psychotic illness. In adult samples, high basic symptom scores are regarded as specific risk factors for the development of schizophrenia. The aim of this study was to explore the relevance of basic symptoms of psychiatric disorders in adolescent patients with special focus on early detection of psychosis. Furthermore, the association between basic symptoms and personality traits has been investigated. Method: From89 adolescents, who were consecutive inpatients with different psychiatric disorders in 1995 and 1997, 54 were followed up 4.7 years later. Patients were examined with the Bonn Scale for the Assessment of Basic Symptoms at the time of the first presentation and follow-up. Additionally, personality traits were assessed at follow-up using the Junior Temperament and Character Inventory. Results: Noneof the subjects made the transition to schizophrenia, despite high baseline scores of basic symptoms at the initial assessment. Indirect minus symptoms were found to be the most valid predictor of a persisting psychiatric diagnosis. In addition, this specific category was strongly associated with the personality traits harm avoidance and self-directedness. Conclusion: Inadolescents, basic symptomsin association with personality traitspresent as a nonspecificindicator of psychopathology rather than as an indicator of vulnerability to schizophrenia.
On the performance of biological movement detectors and ideal velocity sensors in the context of optomotor course stabilization

It is often assumed that the ultimate goal of a motion-detection system is to faithfully represent the time-dependent velocity of a moving stimulus. This assumption, however, may be an arbitrary standard since the requirements for a motion-detection system depend on the task that is to be solved. In the context of optomotor course stabilization, the performance of a motion-sensitive neuron in the fly's optomotor pathway and of a hypothetical velocity sensor are compared for stimuli as are characteristic of a normal behavioral situation in which the actions and reactions of the animal directly affect its visual input. On average, tethered flies flying in a flight simulator are able to compensate to a large extent the retinal image displacements as are induced by an external disturbance of their flight course. The retinal image motion experienced by the fly under these behavioral closed-loop conditions was replayed in subsequent electrophysiological experiments to the animal while the activity of an identified neuron in the motion pathway was recorded. The velocity fluctuations as well as the corresponding neuronal signals were analyzed with a statistical approach taken from signal-detection theory. An observer scrutinizing either signal performs almost equally well in detecting the external disturbance.
Maximal oxygen uptake during cycling is reduced in moving environments; consequences for motion-induced fatigue

In previous studies on physical fatigue during simulated ship movements, the apparent exhaustion of subjects after experimentation suggested that the traditional index of physical workload, oxygen consumption expressed as the percentage of peak oxygen consumption ([Vdot]O2-peak) measured in a separate graded exercise test (GXT), underestimates workload in a moving environment. In these studies, the GXT was carried out in a stationary environment, as is standard practice. To explain the underestimation, it was hypothesized that [Vdot]O2-peak might have been less if the GXT had been carried out in the moving environment. This paper reports on three experimental tests of this hypothesis, performed with a ship motion simulator and aboard a ship at sea. In all three experiments, [Vdot]O2-peak was indeed significantly reduced when the GXT was carried out in the moving environment. Theoretical reasons for this phenomenon are discussed and investigated, but a clear explanation is still lacking.
Extremely low frequency electromagnetic fields stimulation modulates autoimmunity and immune responses: a possible immuno-modulatory therapeutic effect in neurodegenerative diseases

Increasing evidence shows that extremely low frequency electromagnetic fields (ELF-EMFs) stimulation is able to exert a certain action on autoimmunity and immune cells. In the past, the efficacy of pulsed ELF-EMFs in alleviating the symptoms and the progression of multiple sclerosis has been supported through their action on neurotransmission and on the autoimmune mechanisms responsible for demyelination. Regarding the immune system, ELF-EMF exposure contributes to a general activation of macrophages, resulting in changes of autoimmunity and several immunological reactions, such as increased reactive oxygen species-formation, enhanced phagocytic activity and increased production of chemokines. Transcranial electromagnetic brain stimulation is a non-invasive novel technique used recently to treat different neurodegenerative disorders, in particular Alzheimer's disease. Despite its proven value, the mechanisms through which EMF brain-stimulation exerts its beneficial action on neuronal function remains unclear. Recent studies have shown that its beneficial effects may be due to a neuroprotective effect on oxidative cell damage. On the basis of in vitro and clinical studies on brain activity, modulation by ELF-EMFs could possibly counteract the aberrant pro-inflammatory responses present in neurodegenerative disorders reducing their severity and their onset. The objective of this review is to provide a systematic overview of the published literature on EMFs and outline the most promising effects of ELF-EMFs in developing treatments of neurodegenerative disorders. In this regard, we review data supporting the role of ELF-EMF in generating immune-modulatory responses, neuromodulation, and potential neuroprotective benefits. Nonetheless, we reckon that the underlying mechanisms of interaction between EMF and the immune system are still to be completely understood and need further studies at a molecular level.
Using Cross-Entity Inference to Improve Event Extraction

Event extraction is the task of detecting certain specified types of events that are mentioned in the source language data. The state-of-the-art research on the task is transductive inference (e.g. cross-event inference). In this paper, we propose a new method of event extraction by well using cross-entity inference. In contrast to previous inference methods, we regard entity-type consistency as key feature to predict event mentions. We adopt this inference method to improve the traditional sentence-level event extraction system. Experiments show that we can get 8.6% gain in trigger (event) identification, and more than 11.8% gain for argument (role) classification in ACE event extraction.
Dye Advection Without the Blur: A Level‐Set Approach for Texture‐Based Visualization of Unsteady Flow

Dye advection is an intuitive and versatile technique to visualize both steady and unsteady flow. Dye can be easily combined with noise‐based dense vector field representations and is an important element in user‐centric visual exploration processes. However, fast texture‐based implementations of dye advection rely on linear interpolation operations that lead to severe diffusion artifacts. In this paper, a novel approach for dye advection is proposed to avoid this blurring and to achieve long and clearly defined streaklines or extended streak‐like patterns. The interface between dye and background is modeled as a level‐set within a signed distance field. The level‐set evolution is governed by the underlying flow field and is computed by a semi‐Lagrangian method. A reinitialization technique is used to counteract the distortions introduced by the level‐set evolution and to maintain a level‐set function that represents a local distance field. This approach works for 2D and 3D flow fields alike. It is demonstrated how the texture‐based level‐set representation lends itself to an efficient GPU implementation and therefore facilitates interactive visualization.
Performance Sensitivity to Higher Order Moments of Call Interruption and Cell Dwell Times in Cellular Networks

In this paper, sensitivity of the first three standardized moments of both unencumbered call interruption time and cell dwell time on teletraffic performance metrics of wireless cellular networks is investigated. Mathematical analysis for obtaining system-level performance metrics is developed considering that cell dwell time and unencumbered call interruption time are phase-type distributed random variables. Numerical results allow us to quantify the extent by which system performance depends on first three standardized moments of both cell dwell time and unencumbered interruption time.
The role of occlusal factor in the etiology of temporomandibular dysfunction.

INTRODUCTION The influence of occlusal condition at the onset of temporomandibular disorders (TMD) has been strongly debated for many years and still is the source of controversy. Up to the eighties in the last century, the occlusal factors such as the presence of uncured malocclusions, discrepancies between intercuspal position and retruded contact position greater than two millimeters, retrusive and nonworking side interferences and loss of posterior teeth were considered to be the primary causes of TMD. OBJECTIVE The aim of this study was to estimate the role of occlusal factor in the etiology of craniomandibular dysfunction and therapeutic effects of irreversible occlusal therapy (occlusal equilibration) in patients with TMD. METHODS In the investigation we studied a group of 200 men and women. The average age of the selected patients was between 18 and 25 years. The purpose of TMD signs and symptoms was confirmed in every patient using a special functional analysis and evaluating the craniomandibular index (CMI) according to Fricton and Schiffman. The value of craniomandibular index was determined in the group of 15 patients with signs and symptoms of temporomandibular dysfunction. In the study groups occlusal equilibration (selective grinding) was performed according to Okeson using the central position of the mandible as the referent position in the occlusal therapy. The value of CMI was determined before and 30 days after occlusal equilibration. RESULTS The results of this study confirmed the significant reduction in the signs and symptoms of TMD after occlusal equilibration. The statistical elaboration of the differences between the values of CMI I (before treatment) and CMI II (30 days after treatment) revealed highly significant differences. The CMI I values in the group ranged between 0.076 and 0.346 with the mean value of 0.188 +/- 0.082. The values of CMI II ranged between 0.038 and 0.19 with the mean value of 0.038 +/- 0.053. CONCLUSION The study conformed the validity of irreversible occlusal therapy (selective grinding) in patients with TMD.
VAR2CSA Signatures of High Plasmodium falciparum Parasitemia in the Placenta

Plasmodium falciparum infected erythrocytes (IE) accumulate in the placenta through the interaction between Duffy-binding like (DBL) domains of parasite-encoded ligand VAR2CSA and chondroitin sulphate-A (CSA) receptor. Polymorphisms in these domains, including DBL2X and DBL3X, may affect their antigenicity or CSA-binding affinity, eventually increasing parasitemia and its adverse effects on pregnancy outcomes. A total of 373 DBL2X and 328 DBL3X sequences were obtained from transcripts of 20 placental isolates infecting Mozambican women, resulting in 176 DBL2X and 191 DBL3X unique sequences at the protein level. Sequence alignments were divided in segments containing combinations of correlated polymorphisms and the association of segment sequences with placental parasite density was tested using Bonferroni corrected regression models, taking into consideration the weight of each sequence in the infection. Three DBL2X and three DBL3X segments contained signatures of high parasite density (P<0.003) that were highly prevalent in the parasite population (49–91%). Identified regions included a flexible loop that contributes to DBL3X-CSA interaction and two DBL3X motifs with evidence of positive natural selection. Limited antibody responses against signatures of high parasite density among malaria-exposed pregnant women could not explain the increased placental parasitemia. These results suggest that a higher binding efficiency to CSA rather than reduced antigenicity might provide a biological advantage to parasites with high parasite density signatures in VAR2CSA. Sequences contributing to high parasitemia may be critical for the functional characterization of VAR2CSA and the development of tools against placental malaria.
Comorbid clinical conditions in chronic fatigue

OBJECTIVES: Chronically fatiguing illness, defined as fatigue for at least 6 months, has been associated with various physical health conditions. Our objective was to determine whether there is a significant relationship between chronically fatiguing illness and 10 clinical conditions that frequently appear to be associated with fatigue, adjusting for the potentially confounding effects of psychiatric illness.DESIGN: A co-twin control study controlling for genetic and many environmental factors by comparing chronically fatigued twins with their nonfatigued co-twins.SETTING: A nationally distributed volunteer twin registry.PARTICIPANTS: The study included 127 twin pairs in which one member of the pair experienced fatigue of at least 6 months’ duration and the co-twin was healthy and denied chronic fatigue. Fatigued twins were classified into three levels using increasingly stringent diagnostic criteria.MEASUREMENTS AND MAIN RESULTS: Twins reported on a history of fibromyalgia, irritable bowel syndrome, multiple chemical sensitivities, temporomandibular disorder, interstitial cystitis, postconcussion syndrome, tension headache, chronic low back pain, chronic pelvic pain (women), and chronic nonbacterial prostatitis (men). The prevalence of these comorbid clinical conditions was significantly higher in the fatigued twins compared to their nonfatigued co-twins. Most notably, compared to their nonfatigued co-twins, the chronically fatigued twins had higher rates of fibromyalgia (> 70% vs <10%) and irritable bowel syndrome (>50% vs <5%). The strongest associations were observed between chronic fatigue and fibromyalgia (odds ratios >20), irritable bowel syndrome, chronic pelvic pain, multiple chemical sensitivities, and temporomandibular disorder (all with odds ratios ≥4). Regression analysis suggested that the number of comorbid clinical conditions associated with chronic fatigue could not be attributed solely to psychiatric illness.CONCLUSIONS: Chronically fatiguing illnesses were associated with high rates of many other clinical conditions. Thus, patients with chronic fatigue may present a complex clinical picture that poses diagnostic and management challenges. Nonetheless, clinicians should assess such patients for the presence of comorbid clinical conditions. Future research should provide a better understanding of the temporal relationship of the onset of fatigue and these conditions, and develop strategies for early intervention.
Supporting Online Material Materials and Methods Figs. S1 to S3 Tables S1 to S4 References Patched1 Regulates Hedgehog Signaling at the Primary Cilium

our long-lived mice are slightly larger and consume about the same or slightly more food than the short-lived controls. Indeed, long-lived systemic Irs2 +/− mice are more insulin sensitive and glucose tolerant than WT mice; however, long-lived brain-specific bIrs2 +/− and bIrs2 −/− mice are insulin resistant, hyperinsuli-nemic, and glucose intolerant. The mechanism responsible for this disparity is unknown. Regardless, our results point to the brain as the site where reduced insulin-like signaling can have a consistent effect to extend mammalian life span—as it does in C. elegans and D. melanogaster (1, 3). As mammals age, compensatory hyperinsuli-nemia usually develops to maintain glucose homeostasis and prevent the progression toward life-threatening type 2 diabetes (6); however, increased circulating insulin might have negative effects on the brain that can reduce life span (4, 21, 23). By directly attenuating brain Irs2 sig-naling, an aging brain can be shielded from the negative effects of hyperinsulinemia that ordinarily develop with overweight and advancing age. Consistent with this hypothesis, moderate daily exercise, calorie restriction, and weight loss— which reduce circulating insulin—might increase life span by attenuating Irs2 signaling in the brain. Other strategies that improve peripheral insulin sensitivity, such as reduced growth hormone sig-naling, could have the same effect (5). Indeed, human centenarians display increased peripheral insulin sensitivity and reduced circulating insulin concentrations (23). Hence, we suggest that the Irs2 signaling cascade in the brain integrates the effects of peripheral nutrient homeostasis with life span. Primary cilia are essential for transduction of the Hedgehog (Hh) signal in mammals. We investigated the role of primary cilia in regulation of Patched1 (Ptc1), the receptor for Sonic Hedgehog (Shh). Ptc1 localized to cilia and inhibited Smoothened (Smo) by preventing its accumulation within cilia. When Shh bound to Ptc1, Ptc1 left the cilia, leading to accumulation of Smo and activation of signaling. Thus, primary cilia sense Shh and transduce signals that play critical roles in development, carcinogenesis, and stem cell function. T he Hedgehog (Hh) signaling pathway plays an important role both in embryonic development and in adult stem cell function (1, 2). Dysregulation of the pathway causes birth defects and human cancer (2). Despite the importance of Hh signaling in mammals, there are gaps in our understanding of early events in this pathway. In the absence of signal, the transmembrane protein Patched1 (Ptc1) keeps the pathway turned off by inhibiting the function of a second transmembrane protein, Smoothened (Smo). …
Polycystic ovary syndrome in the Indian Subcontinent

Polycystic ovary syndrome (PCOS) is a complex, multifaceted, heterogeneous disorder that affects approximately 5 to 10% of women of reproductive age. It is characterized by hyperandrogenism, polycystic ovaries, and chronic anovulation along with insulin resistance, hyperinsulinemia, abdominal obesity, hypertension, and dyslipidemia as frequent metabolic traits (metabolic syndrome) that culminate in serious long-term consequences such as type 2 diabetes mellitus, endometrial hyperplasia, and coronary artery disease. It is one of the most common causes of anovulatory infertility. However, the heterogeneous clinical features of PCOS may change throughout the life span, starting from adolescence to postmenopausal age, largely influenced by obesity and metabolic alterations, and the phenotype of women with PCOS is variable, depending on the ethnic background. The etiology of PCOS is yet to be elucidated; however, it is believed that in utero fetal programming may have a significant role in the development of PCOS phenotype in adult life. Though a woman may be genetically predisposed to developing PCOS, it is only the interaction of environmental factors (obesity) with the genetic factors that results in the characteristic metabolic and menstrual disturbances and the final expression of the PCOS phenotype. Irrespective of geographic locations, a rapidly increasing prevalence of polycystic ovarian insulin resistance syndrome, excess body fat, adverse body fat patterning, hypertriglyceridemia, and obesity-related disease, such as diabetes and cardiovascular disease, have been reported in Asian Indians, suggesting that primary prevention strategies should be initiated early in this ethnic group. In lieu of the epidemic increase in the prevalence of obesity and diabetes mellitus in most industrialized countries including China and India owing to Westernization, urbanization, and mechanization, and evidence suggesting a pathogenetic role of obesity in the development of PCOS and related infertility, active intervention to combat the malice of these disorders is warranted. Pharmacologic therapy is a critical step in the management of patients with metabolic syndrome when lifestyle modifications fail to achieve the therapeutic goals, and studies in China and India have proved to be effective.
The effects of high-tannin leaf litter from transgenic poplars on microbial communities in microcosm soils

The impacts of leaf litter from genetically modified hybrid poplar accumulating high levels of condensed tannins (proanthocyanidins) were examined in soil microcosms consisting of moss growing on sieved soil. Moss preferentially proliferated in microcosms with lower tannin content; DGGE (denaturing gradient gel electrophoresis) detected increased fungal diversity in microcosms with low-tannin litter. The proportion of cloned rDNA sequences from Actinobacteria decreased with litter addition while Bacteroidetes, Chloroflexi, Cyanobacteria, and α-Proteobacteria significantly increased. β-Proteobacteria were proportionally more numerous at high-tannin levels. Tannins had no significant impact on overall diversity of bacterial communities analyzed with various estimators. There was an increased proportion of N-fixing bacteria corresponding to the addition of litter with low-tannin levels. The addition of litter increased the proportion of Ascomycota/Basidiomycota. Dothideomycetes, Pucciniomycetes, and Tremellomycetes also increased and Agaricomycetes decreased. Agaricomycetes and Sordariomycetes were significantly more abundant in controls, whereas Pucciniomycetes increased in soil with litter from transformed trees (P = 0.051). Richness estimators and diversity indices revealed no significant difference in the composition of fungal communities; PCoA (principal coordinate analyses) partitioned the fungal communities into three groups: (i) those with higher amounts of added tannin from both transformed and untransformed treatments, (ii) those corresponding to soils without litter, and (iii) those corresponding to microcosms with litter added from trees transformed only with a β-glucuronidase control vector. While the litter from transformed poplars had significant effects on soil microbe communities, the observed impacts reflected known impacts on soil processes associated with tannins, and were similar to changes that would be expected from natural variation in tannin levels.