Miracle-dz/UniFAR-FTUs huggingface dataset:
Comparison of product drying performance in molded and serum tubing vials using gentamicin sulfate as a model system

In a previous study, heat transfer coefficients of different 10 mL tubing and molded vials were determined gravimetrically via sublimation tests with pure water. Contrary to “conventional wisdom”, only small differences in Kv values between tubing and molded vials were found in the pressure range relevant for pharmaceutical freeze-drying. In order to investigate the impact of these relatively small differences on the primary drying time of an actual product, freeze-drying experiments with 5% gentamicin sulfate solution as a model system were performed at 68, 100 and 200 mTorr. The primary drying times of the API in recently developed molded (EasyLyo™), tubing (TopLyo™) and polymer vials (TopPac™) were compared. At 68 and 100 mTorr the primary drying time of the drug in the glass vials only differed by 3% to 4%, while the polymer vial took around 9% longer. At 200 mTorr, the API in the EasyLyo™ vials dried approximately 15% faster compared to the other vial types. The present study suggest that molded vials that have been modified in design to have better heat transfer properties can achieve drying times comparable to tubing vials.
Performance on a probabilistic inference task in healthy subjects receiving ketamine compared with patients with schizophrenia

Evidence suggests that some aspects of schizophrenia can be induced in healthy volunteers through acute administration of the non-competitive NMDA-receptor antagonist, ketamine. In probabilistic inference tasks, patients with schizophrenia have been shown to ‘jump to conclusions’ (JTC) when asked to make a decision. We aimed to test whether healthy participants receiving ketamine would adopt a JTC response pattern resembling that of patients. The paradigmatic task used to investigate JTC has been the ‘urn’ task, where participants are shown a sequence of beads drawn from one of two ‘urns’, each containing coloured beads in different proportions. Participants make a decision when they think they know the urn from which beads are being drawn. We compared performance on the urn task between controls receiving acute ketamine or placebo with that of patients with schizophrenia and another group of controls matched to the patient group. Patients were shown to exhibit a JTC response pattern relative to their matched controls, whereas JTC was not evident in controls receiving ketamine relative to placebo. Ketamine does not appear to promote JTC in healthy controls, suggesting that ketamine does not affect probabilistic inferences.
KinectTouch: accuracy test for a very low-cost 2.5D multitouch tracking system

We present a simple solution for a touch detection system on any display at a very low cost. By using a Microsoft Kinect, we can detect fingers and objects on and above a display. We conducted a user study in order to evaluate the accuracy of this system compared to the accuracy of a capacitive touch monitor. The results show, that the system can't compete with an integrated system yet, but works well enough to be used as a touch detection system for large displays.
Modeling In-Use Steel Stock in China's Buildings and Civil Engineering Infrastructure Using Time-Series of DMSP/OLS Nighttime Lights

Abstract: China’s rapid urbanization has led to increasing steel consumption for buildings and civil engineering infrastructure. The in-use steel stock in the same is considered to be closely related to social welfare and urban metabolism. Traditional approaches for determining the in-use steel stock are labor-intensive and time-consuming processes and always hindered by the availability of statistical data. To address this issue, this study proposed the use of long-term nighttime lights as a proxy to effectively estimate in-use steel stock for buildings (IUSSB) and civil engineering infrastructure (IUSSCE) at the provincial level in China. Significant relationships between nighttime lights versus IUSSB and IUSSCE were observed for provincial variables in a single year, as well as for time series variables of a single province. However, these relationships were found to differ among provinces (referred to as ―inter-individual differences‖) and with time (referred to as ―temporal differences‖). Panel regression models were therefore proposed to estimate IUSSB and IUSSCE in consideration of the temporal and inter-individual differences based on a dataset covering 1992–2007. These models were validated using data for 2008, and the results showed good estimation for both IUSSB and IUSSCE. The proposed approach
A Proposal for an Interactive Drama Architecture

We approach creating an interactive drama from the viewpoint that having a human author involved in the creation of the drama is a valuable component. Given that there is this author, we suddenly find opposing forces inherent to the system: the amount of interaction we desire to give the User of the system vs. the amount of dramatic control we wish to give the Writer. In this paper, we propose IDA, an Interactive Drama architecture, which is based on the principle of having a real -time Director agent intelligently guiding the User’s experience towards the Writer’s dramatic goals, while at the same time allowing as much User flexibility as possible.
Tectonic evolution of Mars

Any model for the tectonic evolution of Mars must account for two major crustal elements: the Tharsis bulge and the topographically low and lightly cratered northern third of the planet. Ages determined by crater density indicate that both of these elements came into existence very early in Martian history, a conclusion that holds no matter which of the current crater density versus age curves is used. The size of these two major crustal elements and their sequential development suggest that both may be related to a global-scale internal process. It is proposed that the resurfacing of the northern third of Mars is related to subcrustal erosion and isostatic foundering during the life of a first-order convection cell. With the demise of the cell, denser segregations of metallic materials began to coalesce as a gravitatively unstable layer which finally overturned to form the core. In the overturn, lighter crustal material was shifted laterally and underplated beneath Tharsis to cause rapid and permanent isostatic rise. This was followed by a long-lived thermal phase produced by the hot underplate and by the gravitative energy of core formation slowly making its way to the surface to produce the Tharsis volcanics.
Prospective memory in Parkinson disease during a virtual week: effects of both prospective and retrospective demands.

OBJECTIVE This study investigated the effect of Parkinson's disease (PD) on event-based prospective memory tasks with varying demand on (1) the amount of strategic attentional monitoring required for intention retrieval (prospective component), and (2) the retrospective memory processes required to remember the contents of the intention or the entire constellation of prospective memory tasks. METHOD Twenty-four older adults with PD and 28 healthy older adults performed the computerized Virtual Week task, a multi-intention prospective memory paradigm that simulates everyday prospective memory tasks. The Virtual Week included regular (low retrospective memory demand) and irregular (high retrospective memory demand) prospective memory tasks with cues that were focal (low strategic monitoring demand) or less focal (high strategic monitoring demand) to the ongoing activity. RESULTS For the regular prospective memory tasks, PD participants were impaired when the prospective memory cues were less focal. For the irregular prospective memory tasks, PD participants were impaired regardless of prospective memory cue type. PD participants also had impaired retrospective memory for irregular tasks, which was associated with worse prospective memory for these tasks during the Virtual Week. CONCLUSIONS When retrospective memory demands are minimized, prospective memory in PD can be supported by cues that reduce the executive control demands of intention retrieval. However, PD-related deficits in self-initiated encoding or planning processes have strong negative effects on the performance of prospective memory tasks, with increased retrospective memory demand.
The Affine Arbitrage-Free Class of Nelson-Siegel Term Structure Models

We derive the class of arbitrage-free affine dynamic term structure models that approximate the widely-used Nelson-Siegel yield-curve specification. Our theoretical analysis relates this new class of models to the canonical representation of the three-factor arbitrage-free affine model. Our empirical analysis shows that imposing the Nelson-Siegel structure on this canonical representation greatly improves its empirical tractability; furthermore, we find that improvements in predictive performance are achieved from the imposition of absence of arbitrage.
Transactions between child social wariness and observed structured parenting: evidence from a prospective adoption study.

This investigation examined the mutual influences between structured parenting and child social wariness during toddlerhood using a longitudinal adoption design. The sample consisted of 361 adoption-linked families, each including an adopted child, adoptive parents, and a birth mother. Heightened social wariness in children at age 18 months predicted reduced levels of observed structured parenting (i.e., less directive parenting with fewer commands and requests) in adoptive mothers at age 27 months. Adoptive fathers' lower structured parenting at age 18 months predicted subsequent elevation in child social wariness. Birth mothers' history of fear-related anxiety disorders was not associated with child social wariness. Findings highlight the role of dynamic family transactions in the development of social wariness during toddlerhood.
Multi-keyword Ranked Search over Encrypted Cloud Data Using RSA Algorithm

Ever since Cloud computing introduced, data owners are motivated to outsource their complex data management systems from local sites to the commercial public cloud for great flexibility and economic savings. But for protecting data privacy, sensitive data have to be encrypted before outsourcing, which obsoletes traditional data utilization based on plaintext keyword search. Thus, enabling an encrypted cloud data search service is of paramount importance. Considering the large number of data users and documents in the cloud, it is necessary to allow multiple keywords in the search request and return documents in the order of their relevance to these keywords. Related works on searchable encryption focus on single keyword search or Boolean keyword search, and rarely sort the search results. In this paper, for the first time, we define and solve the challenging problem of privacy-preserving multi-keyword ranked search over encrypted data in cloud computing (MRSE). We establish a set of strict privacy requirements for such a secure cloud data utilization system. Among various multi-keyword semantics, we choose the efficient similarity measure of “coordinate matching,” i.e., as many matches as possible, to capture the relevance of data documents to the search query. We further use “inner product similarity” to quantitatively evaluate such similarity measure. We first propose a basic idea for the MRSE based on secure inner product computation, and then give two significantly improved MRSE schemes to achieve various stringent privacy requirements in two different threat models. To improve search experience of the data search service, we further extend these two schemes to support more search semantics. Thorough analysis investigating privacy and efficiency guarantees of proposed schemes is given. Experiments on the real-world data set further show proposed schemes indeed introduce low overhead on computation and communication.
Effect of intermittent normobaric hypoxic exposure at rest on haematological, physiological, and performance parameters in multi-sport athletes

Abstract The aim of this study was to determine whether 3 weeks of intermittent normobaric hypoxic exposure at rest was able to elicit changes that would benefit multi-sport athletes. Twenty-two multi-sport athletes of mixed ability were exposed to either a normobaric hypoxic gas (intermittent hypoxic training group) or a placebo gas containing normal room air (placebo group). The participants breathed the gas mixtures in 5-min intervals interspersed with 5-min recovery periods of normal room air for a total of 90 min per day, 5 days per week, over a 3-week period. The oxygen in the hypoxic gas decreased from 13% in week 1 to 10% by week 3. The training and placebo groups underwent a total of four performance tests, including a familiarization and baseline trial before the intervention, followed by trials at 2 and 17 days after the intervention. Time to complete the 3-km run decreased by 1.7%[95% confidence interval (CI) = −0.6 – 3.9%] 2 days after, and by 2.3% (CI = 0.25 − 4.4%) 17 days after, the last hypoxic episode in the training relative to the placebo group. Substantial changes in the training relative to the placebo group also included increased reticulocyte count 2 days (23.5%; CI =−1.9 to 44.9%) and 12 days (14.6%; CI = −7.1 to 36.4%) post-exposure. The effect of intermittent hypoxic training on 3-km performance found in this study is likely to be beneficial, which suggests non-elite multi-sport athletes should expect such training to enhance performance.
Evolution of a predator-induced, nonlinear reaction norm

Inducible, anti-predator traits are a classic example of phenotypic plasticity. Their evolutionary dynamics depend on their genetic basis, the historical pattern of predation risk that populations have experienced and current selection gradients. When populations experience predators with contrasting hunting strategies and size preferences, theory suggests contrasting micro-evolutionary responses to selection. Daphnia pulex is an ideal species to explore the micro-evolutionary response of anti-predator traits because they face heterogeneous predation regimes, sometimes experiencing only invertebrate midge predators and other times experiencing vertebrate fish and invertebrate midge predators. We explored plausible patterns of adaptive evolution of a predator-induced morphological reaction norm. We combined estimates of selection gradients that characterize the various habitats that D. pulex experiences with detail on the quantitative genetic architecture of inducible morphological defences. Our data reveal a fine scale description of daphnid defensive reaction norms, and a strong covariance between the sensitivity to cues and the maximum response to cues. By analysing the response of the reaction norm to plausible, predator-specific selection gradients, we show how in the context of this covariance, micro-evolution may be more uniform than predicted from size-selective predation theory. Our results show how covariance between the sensitivity to cues and the maximum response to cues for morphological defence can shape the evolutionary trajectory of predator-induced defences in D. pulex.
Large Vocabulary Recognition of Wall Street Journal Sentences at Dragon Systems

In this paper we present some of the algorithm improvements that have been made to Dragon's continuous speech recognition and training programs, improvements that have more than halved our error rate on the Resource Management task since the last SLS meeting in February 1991. We also report the "dry run" results that we have obtained on the 5000-word speaker-dependent Wall Street Journal recognition task, and outline our overall research strategy and plans for the future.In our system, a set of output distributions, known as the set of PELs (phonetic elements), is associated with each phoneme. The HMM for a PIC (phoneme-in-context) is represented as a linear sequence of states, each having an out-put distribution chosen from the set of PELs for the given phoneme, and a (double exponential) duration distribution.In this paper we report on two methods of acoustic modeling and training. The first method involves generating a set of (unimodal) PELs for a given speaker by clustering the hypothetical frames found in the spectral models for that speaker, and then constructing speaker-dependent PEL sequences to represent each PIC. The "spectral model" for a PIC is simply the expected value of the sequence of frames that would be generated by the PIC. The second method represents the probability distribution for each parameter in a PEL as a mixture of a fixed set of unimodal components, the mixing weights being estimated using the EM algorithm. In both models we assume that the parameters are statistically independent.We report results obtained using each of these two methods (RePELing/Respelling and univariate "tied mixtures") on the 5000-word closed-vocabulary verbalized punctuation version of the Wall Street Journal task.
Examining the relationship between early axon growth and transcription factor expression in the developing cerebral cortex

The transcription factors Satb2 (special AT‐rich sequence binding protein 2) and Ctip2 (COUP‐TF interacting protein 2) have been shown to be required for callosal and corticospinal axon growth respectively from subtypes of cerebral cortex projection neurons. In this study we investigated early stages of directed axon growth in the embryonic mouse cerebral cortex, and studied the possible correlation with the expression of Satb2 and Ctip2. Electroporation of an EYFP‐expressing plasmid at embryonic day 13.5 to label developing projection neurons revealed that directed axon growth is first seen in radially migrating neurons in the intermediate zone (IZ), prior to migration into the cortical plate, as has been suggested previously. Onset of expression of SATB2 and CTIP2 was also observed in the IZ, correlating well with this stage of migration and initiation of axon growth. Immunohistochemical staining through embryonic and early postnatal development revealed a significant population of Satb2/Ctip2 co‐expressing cells, while retrograde axon tracing from the corpus callosum at embryonic day 18.5 back‐labelled many neurons with bi‐directional axon processes. However, through retrograde tracing and simultaneous immunohistochemical staining we show that these bi‐directional processes do not correlate with Satb2/Ctip2 co‐expression. Our work shows that although expression of these transcription factors correlates well with the appearance of directed axon growth during cortical development, the transcriptional code underlying the bi‐directional axonal projections of early neocortical neurons is not likely to be the result of Satb2/Ctip2 co‐expression.
Structural, functional, and protein binding analyses of bovine papillomavirus type 1 exonic splicing enhancers

Alternative splicing plays an important role in regulation of bovine papillomavirus type 1 (BPV-1) gene expression. We have recently identified in BPV-1 late pre-mRNAs two purine-rich exonic splicing enhancers (SE1 and SE2) which also stimulate splicing of a Drosophila doublesex (dsx) pre-mRNA containing a suboptimal 3' splice site. In vivo studies now demonstrate that both SE1 and SE2 are required for preferential use of the BPV-1 nucleotide (nt) 3225 3' splice site in nonpermissive cells. Deletion or mutation of either element in a BPV-1 late pre-mRNA switches splicing to the late-specific alternative 3' splice site at nt 3605. To investigate the sequence specificity of these exonic splicing enhancers, various mutant SE1 or SE2 elements were connected to dsx pre-mRNAs and tested for their stimulatory effects on dsx pre-mRNA splicing in vitro. Substitution of U residues for either A or G residues in and around potential ASF/SF2 binding sites in SE1 or SE2 resulted in a significant reduction of splicing enhancer activity. However, the G-to-U substitutions in both enhancers had the largest effect, reducing splicing to near control levels. Further in vitro analyses showed that splicing enhancement by SE2 could be competed with excess unlabeled SE2 RNA, indicating that SE2 activity in HeLa nuclear extracts is mediated by trans-acting factors. UV cross-linking plus immunoprecipitation assays showed that both wild-type SE1 and SE2 RNAs could bind directly to purified HeLa SR proteins SRp30a (ASF/SF2), SRp55, and SRp75. UV cross-linking experiments also identified a 23-kDa protein which binds to SE2 but not SE1. This protein is present in both HeLa nuclear extracts and S100 extracts but absent from SR protein preparations, suggesting that it is not a classical SR protein. Mutant SE elements (containing G- to U-mutations) which had minimal splicing enhancer activity also had very weak binding capacity for these proteins, strongly suggesting that the binding of these proteins is required for splicing enhancer function.
The case for crowd computing

We introduce and motivate "crowd computing", which combines mobile devices and social interactions to achieve large-scale distributed computation. An opportunistic network of mobile devices offers substantial aggregate bandwidth and processing power. In this paper, we analyse encounter traces to place an upper bound on the amount of computation that is possible in such networks. We also investigate a practical task-farming algorithm that approaches this upper bound, and show that exploiting social structure can dramatically increase its performance.
Accuracy Comparison of LS and Squared-Range LS for Source Localization

In this correspondence, we compute a closed-form expression for the asymptotic (large-sample) accuracy of the recently proposed squared-range least-squares (SR-LS) method for source localization [A. Beck, P. Stoica, and J. Li, ¿Exact and approximate solutions of source localization problems,¿ IEEE Trans. Signal Process. , vol. 56, no. 5, pp. 1770-1778, May 2008]. We compare its accuracy to that of the classical least-squares (LS) method and show that LS and SR-LS perform differently in general. We identify geometries where the performances of the methods are identical but also geometries when the difference in performance is unbounded.