Miracle-dz/UniFAR-FTUs huggingface dataset:
Associations between musical abilities and precursors of reading in preschool aged children

The association between music and language, in particular, the overlap in their processing results in the possibility to use one domain for the enhancement of the other. Especially in the preschool years music may be a valuable tool to train language abilities (e.g., precursors of reading). Therefore, detailed knowledge about associations between musical abilities and precursors of reading can be of great use for designing future music intervention studies that target language-related abilities. Hence, the present study investigated the association between music perception as well as music production and precursors of reading. Thereby, not only phonological awareness, the mostly studied precursor of reading, was investigated, but also other precursors were examined. We assessed musical abilities (production and perception) and precursors of reading (phonological awareness, working memory, and rapid retrieval from long-term memory) in 55 preschoolers (27 boys). Fluid intelligence was measured and controlled in the analyses. Results showed that phonological awareness, working memory, and rapid retrieval from long-term memory were related to music perception as well as to music production. Our data suggest that several precursors of reading were associated with music perception as well as music production.
Spatial variability of selected chemical characteristics of paddy soils in Sawah Sempadan, Selangor, Malaysia.

A study was conducted to evaluate the spatial variability of selected soil chemical properties of paddy soils in the Barat Laut Paddy Project area in Selangor. A total of 138 geo-referenced soil samples were collected from the area at 0-20 cm depth after harvest, at an interval of 80-90 m to determine the selected chemical properties: pH, organic carbon, total nitrogen (N), available phosphorus (P) and exchangeable potassium (K). Geostatistical analyses were applied to examine the within-field spatial variability using semivariograms and kriged maps. Kriged maps for each property were prepared using geostatistical software package based on the results of spatial dependence. The effective ranges for the areas were about 6 km for pH, 1 km for organic carbon, 8 km for total N and available P and 9 km for exchangeable K, respectively. Kriged maps produced showed that most of the area have pH values within the range of 4-4.5 (moderately acidic) and high amount of organic carbon content (3-5%). The kriged maps also showed that a large portion of the study area (66%) have high total N (0.30-0.40%), with low amount of available P ( 0.10 cmol(+) kg -1 ). These results suggest the need for a site specific approach in managing paddy soils particularly with regard to nutrient management. The results also suggested that future soil sampling in these area can be carried out by increasing the sampling interval depending on the soil properties, and appropriate management should be applied according to the variations which exist.
Polynomials, Quantum Query Complexity, and Grothendieck's Inequality

We show an equivalence between 1-query quantum algorithms and representations by degree-2 polynomials. Namely, a partial Boolean function $f$ is computable by a 1-query quantum algorithm with error bounded by $\epsilon<1/2$ iff $f$ can be approximated by a degree-2 polynomial with error bounded by $\epsilon'<1/2$. This result holds for two different notions of approximation by a polynomial: the standard definition of Nisan and Szegedy and the approximation by block-multilinear polynomials recently introduced by Aaronson and Ambainis (STOC'2015, arXiv:1411.5729). We also show two results for polynomials of higher degree. First, there is a total Boolean function which requires $\tilde{\Omega}(n)$ quantum queries but can be represented by a block-multilinear polynomial of degree $\tilde{O}(\sqrt{n})$. Thus, in the general case (for an arbitrary number of queries), block-multilinear polynomials are not equivalent to quantum algorithms. Second, for any constant degree $k$, the two notions of approximation by a polynomial (the standard and the block-multilinear) are equivalent. As a consequence, we solve an open problem of Aaronson and Ambainis, showing that one can estimate the value of any bounded degree-$k$ polynomial $p:\{0, 1\}^n \rightarrow [-1, 1]$ with $O(n^{1-\frac{1}{2k}})$ queries.
Evaluating behavioral and neuroimaging data on past tense processing

Jaeger, Lockwood, Kemmerer, Van Valin, Murphy, and Khalak 1996 (Language 72.3) reported an experimental study that provided reaction time and PET neuroimaging data said to support Pinker's (1991) theory of inflectional morphology in which rule-governed forms and exceptions are processed by separate mechanisms. The results were also taken as evidence against connectionist accounts in which a single processing system generates both types of forms. We provide a critical analysis of the study that yields three main conclusions: First, Jaeger et al.'s data do not provide strong evidence that rule-governed forms and exceptions are processed in separate brain regions. Second, there are problems with the design of the study that contaminate critical comparisons between conditions. The results therefore afford alternative interpretations related to experiment-specific factors rather than the regular-irregular distinction. Third, the dissociations between rule-governed forms and exceptions observed in studies such as Jaeger et al.'s can be accommodated by the connectionist theory. We conclude by offering suggestions for future research that would overcome the major limitations of this study and provide more decisive evidence bearing on the issues.
The western Pacific monsoon in CMIP5 models: Model evaluation and projections

The ability of 35 models from the Coupled Model Intercomparison Project Phase 5 (CMIP5) to simulate the western Pacific (WP) monsoon is evaluated over four representative regions around Timor, New Guinea, the Solomon Islands and Palau. Coupled model simulations are compared with atmosphere‐only model simulations (with observed sea surface temperatures, SSTs) to determine the impact of SST biases on model performance. Overall, the CMIP5 models simulate the WP monsoon better than previous‐generation Coupled Model Intercomparison Project Phase 3 (CMIP3) models, but some systematic biases remain. The atmosphere‐only models are better able to simulate the seasonal cycle of zonal winds than the coupled models, but display comparable biases in the rainfall. The CMIP5 models are able to capture features of interannual variability in response to the El Niño–Southern Oscillation. In climate projections under the RCP8.5 scenario, monsoon rainfall is increased over most of the WP monsoon domain, while wind changes are small. Widespread rainfall increases at low latitudes in the summer hemisphere appear robust as a large majority of models agree on the sign of the change. There is less agreement on rainfall changes in winter. Interannual variability of monsoon wet season rainfall is increased in a warmer climate, particularly over Palau, Timor and the Solomon Islands. A subset of the models showing greatest skill in the current climate confirms the overall projections, although showing markedly smaller rainfall increases in the western equatorial Pacific. The changes found here may have large impacts on Pacific island countries influenced by the WP monsoon.
Navigating the protein fitness landscape with Gaussian processes

Knowing how protein sequence maps to function (the “fitness landscape”) is critical for understanding protein evolution as well as for engineering proteins with new and useful properties. We demonstrate that the protein fitness landscape can be inferred from experimental data, using Gaussian processes, a Bayesian learning technique. Gaussian process landscapes can model various protein sequence properties, including functional status, thermostability, enzyme activity, and ligand binding affinity. Trained on experimental data, these models achieve unrivaled quantitative accuracy. Furthermore, the explicit representation of model uncertainty allows for efficient searches through the vast space of possible sequences. We develop and test two protein sequence design algorithms motivated by Bayesian decision theory. The first one identifies small sets of sequences that are informative about the landscape; the second one identifies optimized sequences by iteratively improving the Gaussian process model in regions of the landscape that are predicted to be optimized. We demonstrate the ability of Gaussian processes to guide the search through protein sequence space by designing, constructing, and testing chimeric cytochrome P450s. These algorithms allowed us to engineer active P450 enzymes that are more thermostable than any previously made by chimeragenesis, rational design, or directed evolution.
Pharmacokinetics of anthraquinones in rat plasma after oral administration of a rhubarb extract.

A sensitive and specific LC-MS/MS method was developed for simultaneous determination of aloe-emodin, rhein, emodin, chrysophanol and physcion and their conjugates in rat plasma. The lower limit of quantitation of each anthraquinone was 0.020-0.040 µm. Intra-day and inter-day accuracies were 90.1-114.3% and the precisions were <14.6%. The matrix effects were 104.0-113.2%. The method was successfully applied to a pharmacokinetic study in rats receiving a rhubarb extract orally. The area under the concentration-time curve (AUC0-t ) and peak concentration (Cmax ) of free aloe-emodin and emodin in rat plasma were much lower than those of rhein. The amounts of chrysophanol and physcion were too low to be continuously detected. After treating the plasma samples with β-glucuronidases, each anthraquinone was detectable throughout the experimental period (36 h) and showed much higher plasma concentrations and AUC0-t . The free/total ratios of aloe-emodin, rhein and emodin were 6.5, 49.0 and 1.7% for Cmax and 3.7, 32.5 and 1.1% for AUC0-t , respectively. The dose-normalized AUC0-t and Cmax of the total of each anthraquinone were in the same descending order: rhein > emodin > chrysophanol > physcion > aloe-emodin. These findings reveal phase II conjugates as the dominant in vivo existing forms of rhubarb antharquinones and warrant a further study to evaluate their contribution to the herbal activity.
The Next Frontier in Communication and the ECLIPPSE Study: Bridging the Linguistic Divide in Secure Messaging

Health systems are heavily promoting patient portals. However, limited health literacy (HL) can restrict online communication via secure messaging (SM) because patients' literacy skills must be sufficient to convey and comprehend content while clinicians must encourage and elicit communication from patients and match patients' literacy level. This paper describes the Employing Computational Linguistics to Improve Patient-Provider Secure Email (ECLIPPSE) study, an interdisciplinary effort bringing together scientists in communication, computational linguistics, and health services to employ computational linguistic methods to (1) create a novel Linguistic Complexity Profile (LCP) to characterize communications of patients and clinicians and demonstrate its validity and (2) examine whether providers accommodate communication needs of patients with limited HL by tailoring their SM responses. We will study >5 million SMs generated by >150,000 ethnically diverse type 2 diabetes patients and >9000 clinicians from two settings: an integrated delivery system and a public (safety net) system. Finally, we will then create an LCP-based automated aid that delivers real-time feedback to clinicians to reduce the linguistic complexity of their SMs. This research will support health systems' journeys to become health literate healthcare organizations and reduce HL-related disparities in diabetes care.
The role of concomitant respiratory diseases on the rate of decline in FEV1 among adult asthmatics

Several recent reports have presented evidence suggesting that adults with asthma have an accelerated rate of decline in pulmonary function compared with nonasthmatics. However, most of these studies have not taken into account the possible effect of comorbid lung disease in addition to asthma. This study was designed to determine if comorbid respiratory diseases modify or otherwise change the estimates of decline in forced expiratory volume in one second (FEV1). Study subjects were White, non-Mexican, American participants, who were ≥20 yrs of age at the initial survey and had at least one pulmonary function testing. Respiratory disease status, based on self-reported questionnaires and pulmonary function tests, were assessed during 12 surveys spanning a period of up to 20 yrs. There were 2,926 subjects who met the inclusion criteria, 214 (7.3%) had physician-confirmed asthma, 325 (11.1%) chronic obstructive pulmonary disease (COPD), and 125 (4.3%) both physician-confirmed asthma and COPD. Longitudinal analysis revealed that among those with longstanding asthma, FEV1 values were low but did not decline at a more rapid rate than normal. Likewise, subjects with both asthma and COPD had the lowest levels of FEV1, but also a rate of decline that was not significantly increased. Only those with COPD in the absence of asthma experienced both a low initial FEV1 level and a significantly steeper rate of decline. Based on these findings, the authors conclude that forced expiratory volume in one second does not decline more rapidly in asthmatics or in those with asthma and chronic obstructive pulmonary disease, compared with nonasthmatics.
Cancer Therapy : Preclinical Superior Ef fi cacy of a Combined Epigenetic Therapy against Human Mantle Cell Lymphoma Cells

Purpose: A deregulated epigenome contributes to the transformed phenotype of mantle cell lymphoma (MCL). This involves activity of the polycomb repressive complex (PRC) 2, containing three core proteins, EZH2, SUZ12, and EED, in which the SET domain of EZH2 mediates the histone methyltransferase activity. We determined the effects of 3-deazaneplanocin A (DZNep), an S-adenosylhomocysteine hydrolase inhibitor, and/or pan-histone deacetylase inhibitor panobinostat (PS) on cultured and primary MCL cells. Experimental Design: Following treatment withDZNep and/or PS, apoptosis and the levels and activity of EZH2 and PRC2 proteins in cultured and primary MCL cells were determined. Results: Treatment with DZNep depleted EZH2, SUZ12, and 3MeK27H3 in the cultured human MCL cells. DZNep also increased expression of p21, p27, and FBXO32, whereas it depleted Cyclin D1 and Cyclin E1 levels inMCL cells. In addition, DZNep treatment induced cell-cycle arrest and apoptosis in cultured and primary MCL cells. Furthermore, as compared with treatment with each agent alone, cotreatment with DZNep and PS caused greater depletion of EZH2, SUZ12, 3MeK27H3, and Cyclin D1 levels, whereas it induced greater expression of FBXO32, p16, p21, and p27. Combined treatment with DZNep and PS synergistically induced apoptosis of cultured and primary MCL cells while relatively sparing normal CD34 þ cells. Cotreatment with DZNep and PS also caused significantly greater inhibition of tumor growth of JeKo-1 xenografts in NOD/SCID mice. Conclusions: These preclinical in vitro and in vivo findings show that cotreatment with DZNep and PS is an active combined epigenetic therapyworthy of further in vivo testing againstMCL.Clin Cancer Res; 18(22);
The evolution of T‐cell depletion in haploidentical stem‐cell transplantation

T‐cell depletion (TCD) can prevent the onset of graft‐versus‐host disease (GvHD) in animal models of bone marrow transplantation; this manipulation enabled the successful application in the 1980s of T‐cell depleted bone marrow (BM) for the treatment of babies with severe combined immune deficiency (SCID). However, in leukaemia patients, implementation of T‐cell depletion has been more difficult, especially due to high rate of graft‐rejection, leukaemia relapse and delayed immune reconstitution. These hurdles were gradually overcome by modifying the cell composition of the graft, and by reducing the toxicities associated with conditioning protocols. Although no ‘gold standard’ TCD method exists, T‐cell depletion in its modern forms could offer clinical benefit, even for patients with a matched sibling donor.
Curcuminoid EF24 enhances the anti‐tumour activity of Akt inhibitor MK‐2206 through ROS‐mediated endoplasmic reticulum stress and mitochondrial dysfunction in gastric cancer

Gastric cancer is one of the leading causes of morbidity and mortality worldwide. Akt is an anti‐apoptotic kinase that plays a dynamic role in cell survival and is implicated in the pathogenesis of gastric cancer. MK‐2206, the first allosteric inhibitor of Akt, is in clinical trials for a number of cancers. Although preclinical studies showed promise, clinical trials reported it had no effect when given alone at tolerated doses. The aim of our study was to delineate the effects of MK‐2206 on gastric cancer cells and explore the ability of combination treatments to enhance the anti‐tumour activity of MK‐2206.
Multi‐scale analysis of a migrating submarine channel system in a tectonically‐confined basin: The Miocene Gorgoglione Flysch Formation, southern Italy

The Miocene Gorgoglione Flysch Formation records the stratigraphic product of protracted sediment transfer and deposition through a long‐lived submarine channel system developed in a narrow and elongate thrust‐top basin of the Southern Apennines (Italy). Channel‐fill deposits are exposed in an outcrop belt approximately 500 m thick and 15 km long, oriented oblique to the palaeoflow, which was roughly south‐eastward. These exceptional exposures of channel‐fill strata allow the stacking architectures and the evolution of the channel system to be analyzed at multiple scales, enabling the effects of syn‐sedimentary thrust tectonics and basin confinement on the depositional system development to be deciphered. Two end‐member types of elementary channel architecture have been identified: high‐aspect‐ratio, weakly‐confined channels, and low‐aspect‐ratio, incisional channels. Their systematic stacking results in a complex pattern of seismic‐scale depositional architectures that determines the stratigraphic framework of the deep‐water system. From the base of the succession, two prominent channel complex sets have been recognized, namely CS1 and CS2, consisting of amalgamated incisional channel elements and weakly‐confined channel elements. These channelized units are overlain by isolated incisional channels, erosional into mud‐prone slope deposits. The juxtaposition of different channel architectures is interpreted to have been governed by regional thrust‐tectonics, in combination with a high subsidence rate that promoted significant aggradation. In this scenario, the alternating ‘in sequence’ and ‘out of sequence’ tectonic pulses of the basin‐bounding thrusts controlled the activation of coarse‐clastic inputs in the basin and the resulting stacking architectures of channelized units. The tectonically‐driven confinement of the depositional system limited the lateral offset in channel stacking, preventing large‐scale avulsions. This study represents an excellent opportunity to analyze the stratigraphic evolution of a submarine channel system in tectonically‐active settings from an outcrop perspective. It should find wide applicability in analogous depositional systems, whose stratigraphic architecture has been influenced by tectonically‐controlled lateral confinement and associated lateral tilting.
Driver risk evaluation based on acceleration, deceleration, and steering behavior

We propose a driver risk evaluation method based on the analysis of driving data captured with drive recorders. To evaluate the acceleration behavior of each driver we plot the maximum acceleration per minute to velocity on a two-dimensional plane and approximate the distribution by linear regression. We assume that the higher the y-intercept of the line, the quicker the driver accelerates from a stop, and the higher the x-intercept, the higher the preferred speed of travel. To evaluate deceleration behavior, brake pedal operation patterns are classified into four types, based on how the brake is depressed and released. We evaluate deceleration risk levels based on these four braking pattern categories. Steering behavior is evaluated based on the relationship between the radius of road curvature and road design speed as defined in the road construction ordinance. Some correlation is observed between our evaluation results and those manually scored by risk consultants.
Farmers' Response to Winter Wheat Fallow Policy in the Groundwater Funnel Area of China: Case Study of the Hengshui Area, Hebei Province

Farmers' response to the winter wheat cropping policy in groundwater funnel areas is the key factor in promoting fallow plans. Therefore, this paper discusses the farmers responses and the influencing factors for the winter wheat policy in the Hebei groundwater funnel area by using an ordered multivariate logistic model; it aims to provide a theoretical basis for scientifically and rationally developing a rotation policy in the groundwater funnel area. The results revealed that cultivated land has a negative impact on the fallow policy. The number of households, the proportion of farmers, the per capita area of cultivated land, and machinery use have a negative impact on support for the fallow policy. The dependency ratio and land fragmentation have a significant positive impact on support for the fallow policy. Occupation has the greatest marginal effect on understanding of the fallow policy and satisfaction with fallow policy compensation, dependency ratio has the greatest marginal effect on support for the fallow policy. Finally, this paper proposes some policy and other recommendations such as the transfer of the surplus labor force, stronger government supervision of fallow policy compensation, stronger cultural education and greater promotion of the fallow policy. Acknowledgement : This study was supported by the National Natural Science Foundation of China (No. 41561040); the Technology Foundation of Jiangxi Education Department of China (No. KJLD14033 & No. GJJ160431) and the Fok Ying-Tung Fund (No. 141084).
Scrub Typhus Meningitis in South India — A Retrospective Study

Background Scrub typhus is prevalent in India although definite statistics are not available. There has been only one study on scrub typhus meningitis 20 years ago. Most reports of meningitis/meningoencephalitis in scrub typhus are case reports Methods A retrospective study done in Pondicherry to extract cases of scrub typhus admitted to hospital between February 2011 and January 2012. Diagnosis was by a combination of any one of the following in a patient with an acute febrile illness- a positive scrub IgM ELISA, Weil-Felix test, and an eschar. Lumbar puncture was performed in patients with headache, nuchal rigidity, altered sensorium or cranial nerve deficits. Results Sixty five cases of scrub typhus were found, and 17 (17/65) had meningitis. There were 33 males and 32 females. Thirteen had an eschar. Median cerebrospinal fluid (CSF) cell count, lymphocyte percentage, CSF protein, CSF glucose/blood glucose, CSF ADA were 54 cells/µL, 98%, 88 mg/dL, 0.622 and 3.5 U/mL respectively. Computed tomography was normal in patients with altered sensorium and cranial nerve deficits. Patients with meningitis had lesser respiratory symptoms and signs and higher urea levels. All patients had received doxycycline except one who additionally received chloramphenicol. Conclusion Meningitis in scrub typhus is mild with quick and complete recovery. Clinical features and CSF findings can mimic tuberculous meningitis, except for ADA levels. In the Indian context where both scrub typhus and tuberculosis are endemic, ADA and scrub IgM may be helpful in identifying patients with scrub meningitis and in avoiding prolonged empirical antituberculous therapy in cases of lymphocytic meningitis.