Miracle-dz/UniFAR-FTUs huggingface dataset:
Blood‐Brain Barrier Disruption Due to Cerebral Arteriography: CT Findings

Computed tomography was performed in two cases of blood-brain barrier (BBB) disruption due to cerebral arteriography. The first case showed diffuse contrast enhancement in the right frontotemporal region in the distribution of the middle cerebral artery; in the second case patchy contrast enhancement in both gray and white matter of both hemispheres was demonstrated. The possible mechanism for BBB disruption in these patients is discussed.
Recall of Television Advertisements as a Function of Program Evaluation

Abstract The effects of program content and program evaluation on viewers' ability to remember advertisements placed in the middle of a television program were examined. University undergraduates (N = 129) took part in what was described to them as a program evaluation study. Results showed no differences in recall as a function of the content of the program watched, but program evaluation ratings were significantly related to recall of advertisements. Greater program involvement as indicated by measures of liking, perceived credibility, perceived contemporaneity, and affective response was associated with poorer free and cued recall of advertising content.
Flawed meta-analyses comparing psychotherapy with pharmacotherapy.

OBJECTIVE The author sought to illustrate the invalidity of meta-analyses that claim to quantitatively compare the benefits of psychotherapy to pharmacotherapy in patients with psychiatric disorders. METHOD Studies included in four meta-analyses were retrieved and their study designs evaluated. RESULTS The meta-analyses compared effect sizes from disparate studies that were not uniformly blind, random, controlled, or of high quality. The studies did not directly address the comparative efficacy question or lacked assay sensitivity. CONCLUSIONS Numerous types of studies exemplify the need for caution in evaluating meta-analytic conclusions without first critically examining the included studies. Estimates of the relative efficacy of different treatments are not well founded when based almost exclusively on indirect, multiply confounded comparisons. Meta-analyses based on flawed studies or studies that lack demonstrated assay sensitivity are also inadequate for the criticism of treatment guidelines. Some bodies of data are inadequate to support a proper meta-analysis.
Simulating Market Dynamics: Interactions between Consumer Psychology and Social Networks

Markets can show different types of dynamics, from quiet markets dominated by one or a few products, to markets with continual penetration of new and reintroduced products. In a previous article we explored the dynamics of markets from a psychological perspective using a multi-agent simulation model. The main results indicated that the behavioral rules dominating the artificial consumer's decision making determine the resulting market dynamics, such as fashions, lock-in, and unstable renewal. Results also show the importance of psychological variables like social networks, preferences, and the need for identity to explain the dynamics of markets. In this article we extend this work in two directions. First, we will focus on a more systematic investigation of the effects of different network structures. The previous article was based on Watts and Strogatz's approach, which describes the small-world and clustering characteristics in networks. More recent research demonstrated that many large networks display a scale-free power-law distribution for node connectivity. In terms of market dynamics this may imply that a small proportion of consumers may have an exceptional influence on the consumptive behavior of others (hubs, or early adapters). We show that market dynamics is a self-organized property depending on the interaction between the agents' decision-making process (heuristics), the product characteristics (degree of satisfaction of unit of consumption, visibility), and the structure of interactions between agents (size of network and hubs in a social network).
Methylphenidate facilitates and disinhibits the motor cortex in intact humans

Animal experiments show that motor recovery after focal brain injury is accelerated by the indirect norepinephrine agonist methylphenidate (MPH). The underlying mechanisms are unknown, but an MPH-induced increase in cortical excitability has been advocated. Here, we tested the acute effects of a single oral dose of 40 mg MPH (Ritalin) on motor cortical excitability in eight healthy subjects using focal transcranial magnetic stimulation. MPH increased the slope of the motor evoked potentials (MEP) intensity curve in a hand muscle, reduced short-interval intracortical inhibition, and increased I-wave facilitation. MEP threshold, cortical silent period and measures of spinal and neuromuscular excitability remained unaffected. Findings support the idea that MPH promotes accelerated motor recovery after lesion through facilitation and disinhibition.
OLDER ADULTS, COMPUTER TRAINING, AND THE SYSTEMS APPROACH: A FORMULA FOR SUCCESS

Adults over the age of 65 are the fastest growing segment of computer users. Due to this increased demand, effective training programs are essential. Although previous research findings illustrate the importance of older adults’ goals, abilities, and experience levels in learning to use computers, these factors are often neglected in the development of computer training courses. We apply a systems approach to help bridge this gap between research and practice to address the disparity between what older adults would like to learn and the content of computer training courses. We review the literature on training older adults to use computers and report data from a set of structured interviews to illustrate the criticality of each step in the systems approach. Lastly, we provide the means to evaluate existing computer training programs and suggest modifications for improvement. Our purpose is not to evaluate specific programs, but to educate developers about an approach that has proven successful. Specifically, we provide suggestions for effective computer training for older adults.
Student-Teaching Experiences and Attitudes of Student Teachers

cess (i, :L 4, :19: Ch. i, 32). Although none of these social scientists refer specifically to the student-teaching setting, an investigation of the relationships between student teachers and cooperating teachers would seem to be a natural outgrowth of their hypotheses. The particular approach of the present investigation was suggested by the conceptualization developed by Getzels and his colleagues (8). =’ Initially, following such writers as Linton (22, 21), Newcomb (25, 24, 23), and Parsons (26, 27), Getzels conceived of social systems as being made up of two main components: institutions and individuals. Just as individuals have certain individual needs
Assessment of the quality of an organizational citizenship behavior instrument

Organizational citizenship behavior (OCB) has been associated with organizational effectiveness in many studies. Therefore, it is important to learn more about how these behaviors can be improved in schools. Creating a reliable and valid measure of OCB that has conceptual equivalence across cultures is a first step in understanding and accumulating systematic knowledge of this construct. This study sought to validate in a Turkish school context a three-dimensional conceptualization and measurement of OCB created by Somech and Drach-Zahavy (2000). A confirmatory factor analysis of data from a sample of 710 school teachers supported the hypothesized factorial structure of the scales. In addition, 3 subscales correlated with an organizational commitment measure in the expected magnitude and direction, which provides evidence of the predictive validity of the scales.
Allopregnanolone and Its Precursor Progesterone Do Not Reduce Injury after Experimental Stroke in Hypertensive Rats – Role of Postoperative Temperature Regulation?

Allopregnanolone is a neurosteroid synthesized from progesterone in brain. It increases inhibition through modulation of the gamma-aminobutyric acid type A (GABA-A) receptor. Both agents are putative neuroprotectants after ischemic stroke. We sought to confirm their effectiveness in a hypertensive rat stroke model, with intra- and post-operative temperature regulation. The primary study compared allopregnanolone, progesterone or vehicle control treatments, administered 105 minutes after induction of temporary middle cerebral artery occlusion in spontaneously hypertensive rats. Temperature was controlled intraoperatively and a heat mat used in the 6 hours postoperatively to permit animal temperature self-regulation. The primary outcome was infarct volume and secondary outcomes were tests of sensory and motor function. There was no significant effect of treatment on any outcome measure. Given prior reports of GABA-A receptor agonists causing hypothermia, follow-up experiments were conducted to examine postoperative temperature regulation. These did not reveal a difference in postoperative temperature in neurosteroid-treated animals compared to control. However, in all rats maintained postoperatively in ambient temperature, moderate hypothermia was observed. This was in contrast to rats maintained over a heat mat. The lowest mean postoperative temperature was between 34.4–34.9°C in all 3 groups. These data do not support a neuroprotective effect of allopregnanolone or progesterone in ischemic stroke in hypertensives in the setting of normothermia. Given previous evidence of synergy between neuroprotective agents and hypothermia, demonstration of neuroprotective effect of these agents in the absence of postoperative hypothermia would be prudent before consideration of these agents for further clinical investigation.
Entry, Exit and the Determinants of Market Structure

Market structure is determined by the entry and exit decisions of individual producers. These decisions are driven by expectations of future profits which, in turn, depend on the nature of competition within the market. In this paper we estimate a dynamic, structural model of entry and exit in an oligopolistic industry and use it to quantify the determinants of market structure and long-run firm values for two U.S. service industries, dentists and chiropractors. We find that entry costs faced by potential entrants, fixed costs faced by incumbent producers, and the toughness of short-run price competition are all important determinants of long run firm values and market structure. As the number of firms in the market increases, the value of continuing in the market and the value of entering the market both decline, the probability of exit rises, and the probability of entry declines. The magnitude of these effects differ substantially across markets due to differences in exogenous cost and demand factors and across the dentist and chiropractor industries. Simulations using the estimated model for the dentist industry show that pressure from both potential entrants and incumbent firms discipline long-run profits. We calculate that a seven percent reduction in the mean sunk entry cost would reduce a monopolist's long-run profits by the same amount as if the firm operated in a duopoly.
The increase of oxygen consumption after a flash of light is tightly coupled to sodium pumping in the lateral ocellus of barnacle

In the lateral ocellus of the barnacle, we have tested the hypothesis that the transient increase of oxygen consumption (delta QO2) induced by light results from an increase in the rate of Na+ pumping. With a Na(+)-sensitive microelectrode, we measured the intracellular concentration of Na+ (Nai) in the photoreceptor cells. Nai was 17.6 +/- 1.2 mM (SE; n = 18) in darkness and it increased transiently by 10-20 mM after an 80-ms flash of intense light. The increase of Nai recovered in about the same time as the delta QO2, and the Na+/O2 ratio was 19.2 +/- 3.8 (SE; n = 6). Removing Na+ from the bath caused the delta QO2 to decrease by 79 +/- 3% (SE; n = 5). Exposure to 25 microM ouabain inhibited Na+ pumping and abolished the delta QO2. Removal of K+ from the bathing solution inhibited Na+ pumping in darkness, but mostly shortened the duration of the delta QO2; with a K(+)-sensitive microelectrode, we measured pericellular [K+] and found that it increased after the flash for about the same time as the delta QO2. Increasing Na+ pumping in darkness by reintroducing K+ in the bath or by injecting Na+ into one of the photoreceptor cells induced a delta QO2. Finally, intracellular injection of adenosine diphosphate and inorganic phosphate (ADP + Pi), the metabolic products of ATP splitting by the Na+ pump, also induced a delta QO2 in darkness. We conclude that all the results obtained are consistent with the formulated hypothesis.
Frames and consensus formation in international relations: The case of trafficking in persons

This article examines the process of consensus formation by the international community regarding how to confront the problem of trafficking in persons. We analyze the corpus of United Nations General Assembly Third Committee resolutions to show that: (1) consensus around the issue of how to confront trafficking in persons has increased over time; and (2) the formation of this consensus depends upon how the issue is framed. We test our argument by examining the characteristics of resolutions’ sponsors and discursive framing concepts such as crime, human rights, and the strength of enforcement language. We conclude that the consensus-formation process in international relations is more aptly described as one of ‘accommodation’ through issue linkage than a process of persuasion.
Spatial negative priming modulation: The influence of probe-trial target cueing, distractor presence, and an intervening response

Reaction times are slower when a target (T) appears at a location that has just contained a distractor (D) (ignored-repetition trial), relative to when it arises at a previously unoccupied spatial position (control trial), i.e., the spatial negative priming (NP) effect. In a typical spatial NP paradigm trials are presented in pairs, first the prime and then the probe. Validly cueing ignored-repetition trials, and/or reducing probe distractor probability, modulated the NP process under certain conditions following target-plus-distractor (prime response) but not after distractor-only (no prime response) primes. This supported the idea that the production of a prime (intervening) response meets the needs for producing NP modulation. Additionally, NP elimination, evident when the probe was randomly distractor-free, was not seen when the probe also contained a distractor event. This suggests that the removal of the NP effect is likely achieved by blocking the retrieval of prime distractor information, rather than by removing the NP cause. Seemingly, the presence of a probe distractor is able to bypass the retrieval block.
The Use of the Assessment of Motor and Process Skills (AMPS) in Predicting Need of Assistance for Adults with Mental Retardation

Because the ability to perform activities of daily living (ADL) is associated with global aspects of community functioning, it is critical to evaluate whether the information gained from specific ADL assessments contributes to a reliable prediction of the overall amount of assistance needed for a person to function in the community. The purpose of this study was to evaluate the predictive use of an ADL assessment, the Assessment of Motor and Process Skills (AMPS), to determine which people with mental retardation need support or assistance to function in the community. A sample of 380 data records from the AMPS international database of people with various levels of mental retardation was included in the study. Many-faceted Rasch analyses and logistic regression models were used for data analysis. The results indicated that only the AMPS ADL process ability measures contributed significantly and substantially to the prediction of the level of assistance required to function in the community for individuals with mild to moderate mental retardation when used in conjunction with age, gender, and level of mental retardation. The results have clinical implications for occupational therapists working with these people because ADL process ability can be improved by occupational therapy interventions.
Improving Lesion-Symptom Mapping

Measures of brain activation (e.g., changes in scalp electrical potentials) have become the most popular method for inferring brain function. However, examining brain disruption (e.g., examining behavior after brain injury) can complement activation studies. Activation techniques identify regions involved with a task, whereas disruption techniques are able to discover which regions are crucial for a task. Voxel-based lesion mapping can be used to determine relationships between behavioral measures and the location of brain injury, revealing the function of brain regions. Lesion mapping can also correlate the effectiveness of neurosurgery with the location of brain resection, identifying optimal surgical targets. Traditionally, voxel-based lesion mapping has employed the chi-square test when the clinical measure is binomial and the Student's t test when measures are continuous. Here we suggest that the Liebermeister approach for binomial data is more sensitive than the chi-square test. We also suggest that a test described by Brunner and Munzel is more appropriate than the t test for nonbinomial data because clinical and neuropsychological data often violate the assumptions of the t test. We test our hypotheses comparing statistical tests using both simulated data and data obtained from a sample of stroke patients with disturbed spatial perception. We also developed software to implement these tests (MRIcron), made freely available to the scientific community.
Wage‐Setting Institutions and R&D Collaboration Networks

We analyse how union structures that differ in the degree of wage-setting centralization affect the pattern of R&D network formation. Within the context of a three-firm industry, a central union that sets a uniform wage is shown to induce a partial R&D network that includes two firms but excludes the third. In contrast, we find that, under less centralized union structures, firms have incentives to form R&D networks with a larger number of alliances. This result is consistent with the stylised facts for industrialised countries: recent decades have seen an upsurge in R&D alliances along with labour market deregulation towards more flexible wage-setting institutions.
Effects of the extradural administration of morphine or bupivacaine, on the metabolic response to upper abdominal surgery.

The influence of thoracic extradural local anaesthetics (0.5% bupivacaine) or extradural morphine on the metabolic response to upper abdominal surgery was compared with the administration of morphine i.v. in the period after operation. The extradural local anaesthetic group had significantly lower blood glucose and plasma FFA concentrations and consistently, but not significantly, lower blood glycerol and lactate concentrations than both the other groups. At 4 h both extradural groups had significantly lower plasma FFA and blood 3-hydroxybutyrate concentrations than the control group. Blood alanine concentration decreased in all three groups with a minimum at 24 h. There were no differences in serum insulin concentrations between the groups. It is concluded that thoracic extradural morphine differs from thoracic extradural local anaesthetics in being much less able to suppress the metabolic response associated with upper abdominal surgery.
Solid-phase micro-radioimmunoassay to measure immunoglobulin class-specific antibody to Mycoplasma pulmonis

A solid-phase radioimmunoassay (RIA) was used for the detection and quantitation of immunoglobulin class-specific antibodies to Mycoplasma pulmonis in mouse sera. The RIA was found to be more sensitive than the single radial haemolysis (SRH) test for detecting antibodies in sera from mice at intervals after inoculation with M. pulmonis, since antibody was detected in 26 out of 29 serum samples by RIA but in only 8 out of 29 samples by SRH. A method is described for quantitating immunoglobulin class-specific antibody in test sera by reference to a standard serum. The RIA should be useful for the study of the relative importance of various immunoglobulin classes in resistance to mycoplasma infections.
Predictive Relationships between Web and Human Resource Use and Middle School Students’ Interest in Science Careers: An Exploratory Analysis

This study investigated relationships among the use of web and human resource during science class and science career interest. Results suggested that levels of science career interest could be predicted based on classroom use of web and human resources. Regular use of human resources was predictive of science career interests for boys and girls. Use of web resources was only predictive of girl’s interests, on average, 7 points higher on a 36-point scale than girls who did not use web resources. Girls who used both resources scored 16 points higher than girls who used neither. Two other predictor variables found included (1) teachers who lacked science background and used web resources regularly and (2) level of student-centered instructional strategies used in the classroom. Further research is suggested.
The MAP Kinase MPK4 Is Required for Cytokinesis in Arabidopsis thaliana[W]

Mutations in the Arabidopsis MPK4 MAP kinase caused characteristic defects in cytokinesis, and MPK4 kinase activity was detected in dividing cells. MPK4 was localized to the expanding cell plates, and its expansion in dividing cells of mpk4 roots appeared to be retarded. These results show that MPK4 positively regulates the formation of cell plates in Arabidopsis. Cytokinesis in plants is achieved by the formation of the cell plate. A pathway that includes mitogen-activated protein (MAP) kinase kinase kinase and MAP kinase kinase (MAPKK) plays a key role in the control of plant cytokinesis. We show here that a MAP kinase, MPK4, is required for the formation of the cell plate in Arabidopsis thaliana. Single mutations in MPK4 caused dwarfism and characteristic defects in cytokinesis, such as immature cell plates, which became much more prominent upon introduction of a mutation in MKK6/ANQ, the MAPKK for cytokinesis, into mpk4. MKK6/ANQ strongly activated MPK4 in protoplasts, and kinase activity of MPK4 was detected in wild-type tissues that contained dividing cells but not in mkk6/anq mutants. Fluorescent protein–fused MPK4 localized to the expanding cell plates in cells of root tips. Expansion of the cell plates in mpk4 root tips appeared to be retarded. The level of MPK11 transcripts was markedly elevated in mpk4 plants, and defects in the mpk4 mpk11 double mutant with respect to growth and cytokinesis were more severe than in the corresponding single mutants. These results indicate that MPK4 is the downstream target of MKK6/ANQ in the regulation of cytokinesis in Arabidopsis and that MPK11 is also involved in cytokinesis.