Miracle-dz/UniFAR-FTUs huggingface dataset:
Towards Model Transformation between SecureUML and UMLsec for Role-based Access Control

Nowadays security has become an important aspect in information systems engineering. A mainstream method for information system security is Role-based Access Control (RBAC), which restricts system access to authorised users. Recently different authors have proposed a number of modelling languages (e.g., abuse cases, misuse cases, secure i*, secure Tropos, and KAOS extensions to security) that facilitate the documentation and analysis of security aspects. However it is unclear if these languages support the full spectrum of RBAC specification needs. In this paper we selected two security modelling languages, namely SecureUML and UMLsec. Based on the literature study and on the running example we systematically investigate how these languages could be used for RBAC. Our observations indicate that, although both approaches originate from the de-facto industry standard UML, they are not competitors. Rather they complement each other: SecureUML helps defining static RBAC aspects; UMLsec is recommended for dynamic RBAC analysis. Thus, the combined use of both approaches would provide a more comprehensive approach to secure information system development. As a step towards enabling the combined use of SecureUML and UMLSec, this paper outlines a mapping transformation between these two languages.
Emotional Reactions to Stress Among Adolescent Boys and Girls

This study examines the effects of negative life events on anger and depressed mood among a sample of 7,758 Icelandic adolescents, measured as part of the National Survey of Icelandic Adolescents (Thorlindsson, Sigfusdottir, Bernburg, & Halldorsson, 1998). Using multiple linear regression and multinomial logit regression, we find that (a) girls and boys tend to experience different negative life events, (b) negative life events are associated with comparable levels of anger among boys and girls, (c) negative life events predict depressed mood more strongly among girls than among boys, and (d) conflict with family and friends predicts anger and depressed mood more strongly than other negative life events among boys and girls. These results raise questions about the role of anger and depressed mood in explaining gender differences in stress-related delinquent behavior.
Clinical Efficacy of Ertapenem for Recurrent Cystitis Caused by Multidrug-Resistant Extended-Spectrum β-Lactamase-Producing Escherichia coli in Female Outpatients

Purpose To evaluate the clinical outcomes of ertapenem administered as an outpatient parenteral antibiotic therapy for intractable cystitis caused by extended-spectrum β-lactamase (ESBL)-producing Escherichia coli. Materials and Methods We retrospectively reviewed a case series of 3 years of therapeutic experience with ertapenem for intractable recurrent cystitis caused by ESBL-producing E. coli. Ertapenem 1 g/d was parenterally administered to the patients on an outpatient basis until the acquisition of symptomatic improvement and negative conversion of urine culture. Demographic and clinical characteristics of patients, antimicrobial resistance, and clinical response data were analyzed from the patients' medical records. Results During the course of this study, a total of 383 patients were diagnosed with cystitis, and 24 of them showed ESBL-producing E. coli (6.26%). The mean treatment duration of all patients was 8.5 days. The early clinical and microbiological cure rates 0 to 7 days after the end of treatment were 91.7% (22/24) and 90.9% (20/22), respectively. The late clinical and microbiological cure rates 4 to 6 weeks after the end of treatment were 72.2% (13/18) at both time points. Conclusions Parenteral ertapenem treatment can be an effective and well-tolerated treatment option for intractable recurrent cystitis by multidrug-resistant ESBL-producing E. coli.
[An experiment study of reversed pulmonary hypertension with inhaled nitric oxide on smoke inhalation injury].

We evaluated the effect and mechanisms of reversed pulmonary hypertension with inhaled nitric oxide (NO) on smoke inhalation injury in the dog model, 21 dogs were divided into 3 groups randomly. Following smoke inhalation, the control group (n = 8) inhaled O2 (FiO2, 0.45) and the treated group (n = 9) inhaled O2 and 0.0045% (45 ppm) NO. Hemodynamics was serially measured for 12 hours. In addition, 4 dogs without smoke inhalation were used to study the normal lung histomophologic findings. The data were analyzed by ANOVA. After inhalation of NO, the mean pulmonary artery pressure (mPAP), pulmonary minute vessels pressure (Pmv), and pulmonary vascular resistance (PVR) were decreased significantly (P < 0.05), while the mean aortic pressure (mAP) and total peripheral resistance (TRP) were not remarkably changed (P > 0.05). The levels of cyclic guanosine monophosphate (cGMP) were increased significantly (P < 0.01). Inhaled NO may reverse pulmonary hypertension with smoke inhalation injury in dogs. The mechanism of selective pulmonary circulation was increased cGMP level in smooth cells. Inhaled NO may be recommended for clinical application.
Effect of induced alkalosis on exhaustive leg press performance.

PURPOSE Fifteen males were studied before, during, and in recovery from exhaustive resistance exercise 105 min after ingesting 0.3 g.kg-1 of either a placebo (white flour) or sodium bicarbonate (NaHCO3). METHODS The exercise consisted of five maximal sets on a leg press machine, The load was adjusted to maintain the number of repetitions per set for each subject at approximately 12 repetitions. A significant (P < 0.05) increase in pH (7.40 to 7.47), oxygenated base excess (OxyBE) (-1.3 to 4.0 mEq.L-1), and bicarbonate concentration ([HCO3-]) (22.8 to 27.4 mM) was achieved before exercise with the ingestion of NaHCO3. RESULTS The exercise protocol produced significant changes in acid base status consistent with metabolic acidosis for both trials (pH sets 1-5: placebo, 7.4 to 7.26; NaHCO3, 7.47 to 7.33), (OxyBE sets 1-5: placebo, -1.3 to -12.3 mEq.L-1; NaHCO3, 4.0 to -6.9 mEq.L-1) and ([HCO3-] sets 1-5: placebo, 22.9 to 14.0 mM; NaHCO3, 27.4 to 17.6 mM). After every set; pH, OxyBE, and [HCO3-] were significantly higher in the NaHCO3 trial. Blood lactate concentration ([La-]) significantly increased throughout exercise for both trials ([La-] sets 1-5: placebo, 4.6 to 11.3 mM; NaHCO3, 4.8 to 13.4 mM). After sets 4 and 5, blood [La-] was significantly higher in the NaHCO3 trial. Bicarbonate ingestion did not improve performance (total repetitions: NaHCO3 = 59 +/- 3; placebo = 60 +/- 2). CONCLUSIONS This may be a result of a lower demand on the whole body metabolic system in comparison with that for other modes of exercise in which ergogenic effects have been found.
Hybrid Resonant and PWM Converter With High Efficiency and Full Soft-Switching Range

A novel soft-switching converter combining resonant half-bridge and phase-shifted pulsewidth modulation (PWM) full-bridge configuration is proposed to ensure the switches in the leading-leg operating at zero-voltage switching from true zero-load to full-load, and the switches in the lagging leg working at zero-current switching with minimum duty cycle loss and circulating conduction loss by significantly reducing leakage or series inductance. Experimental results of a 3.4-kW hardware prototype show that the circuit achieves true full-range soft switching with 98% peak efficiency. The hybrid resonant and PWM converter is attractive for electrical vehicle battery charger application.
Diagnosis and classification of disorders specifically associated with stress: proposals for ICD‐11

The diagnostic concepts of post‐traumatic stress disorder (PTSD) and other disorders specifically associated with stress have been intensively discussed among neuro‐ and social scientists, clinicians, epidemiologists, public health planners and humanitarian aid workers around the world. PTSD and adjustment disorder are among the most widely used diagnoses in mental health care worldwide. This paper describes proposals that aim to maximize clinical utility for the classification and grouping of disorders specifically associated with stress in the forthcoming 11th revision of the International Classification of Diseases (ICD‐11). Proposals include a narrower concept for PTSD that does not allow the diagnosis to be made based entirely on non‐specific symptoms; a new complex PTSD category that comprises three clusters of intra‐ and interpersonal symptoms in addition to core PTSD symptoms; a new diagnosis of prolonged grief disorder, used to describe patients that undergo an intensely painful, disabling, and abnormally persistent response to bereavement; a major revision of “adjustment disorder” involving increased specification of symptoms; and a conceptualization of “acute stress reaction” as a normal phenomenon that still may require clinical intervention. These proposals were developed with specific considerations given to clinical utility and global applicability in both low‐ and high‐income countries.
The neural circuitry of emotion and affective style: prefrontal cortex and amygdala contributions

This article reviews the modern literature on two key aspects of the central circuitry of emotion - the prefrontal cortex (PFC) and the amygdala. There are several different functional divisions of the PFC including the dorsolateral, ventromedial and orbitofrontal sectors. Each of these regions plays some role in affective processing that shares the feature of representing affect in the absence of immediate rewards and punishments as well as in different aspects of emotional regulation. The amygdala appears to be crucial for the learning of new stimulus-threat contingencies and also appears to be important in the expression of cue-specific fear. Individual differences in both tonic activation and phasic reactivity in this circuit play an important role in governing affective style. Emphasis is placed upon affective chronometry, or the time course of emotional responding, as a key attribute of emotion that varies across individuals and is regulated by this circuitry.
Body Acupuncture for Nicotine Withdrawal Symptoms: A Randomized Placebo-controlled Trial

This study evaluated whether improvements in nicotine withdrawal symptoms (NWS), depression and anxiety are greater for body acupuncture than for sham acupuncture. Smoking volunteers from the public were randomized to receive six sessions of either real or sham acupuncture for 2 weeks. The primary outcome measure was NWS measured by the Minnesota Nicotine Withdrawal Score, and the secondary measures were scores on the Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI). Eighty volunteers were randomized into real acupuncture (n = 38) and sham acupuncture (n = 42) groups, of which 46 subjects (22 and 24 in the real and sham acupuncture groups, respectively) completed the treatment and the 2-week follow-up. An intention-to-treat analysis revealed that the NWS did not differ significantly between the real and sham acupuncture groups immediately after the treatment (12.2 ± 9.7 and 12.8 ± 7.7, respectively; mean ± SD) and at the 2-week follow-up (11.7 ± 10.2 and 12.6 ± 7.8). Both groups also showed similar improvements in BDI and BAI scores. These results indicate that the real acupuncture treatment tested in this trial was no more effective than sham acupuncture at reducing NWS, depression and anxiety for smoking cessation.
Laser Treatment of Facial Telangiectases: An Update

BACKGROUND Telangiectases affect millions of people worldwide, and treatment of these vessels is a common dermatologic request. The advancement of lasers in recent years has led to numerous laser and light devices intended to treat telangiectases. OBJECTIVE AND METHOD A review of the literature on the laser and light devices available for the treatment of telangiectases with both historical and recent trends is presented. RESULTS The appropriate choice of light system to treat telangiectases varies depending on anatomical, physiological, and biological differences in the vessels. Safe and efficacious treatment of facial telangiectases can be achieved with the green and yellow light lasers by taking advantage of the oxyhemoglobin absorption peaks. The authors have indicated no significant interest with commercial supporters.
Nightly@nbc.com: Audience Scope and the Perception of Interactivity in Viewer Mail on the Internet.

A content analysis looked at 650 Internet mail messages sent to NBC Nightly News in response to an invitation during a series dealing with the impact of new technologies. Message indexes were created to reflect the scope of the audience they addressed. Macro-scopic messages were formal, dealt with political issues, and either did not mention technology or mentioned mass media. These messages resembled a letter to a newspaper editor. Mezzoscopic messages were positive and avoided political issues. They congratulated NBC as a team for their work on the technology series and tended to mention computers. Micro-scopic messages stood out for their authors' high perception of interactivity. These messages mentioned computer technology more than any other group and appear similar to face-to-face communication in many ways. Results are discussed in terms of how the relationship between media users' perceived sense of interactivity and the scope of the audience they address are related to message style and content.
Different roles, different views: exploring the range of stakeholder perceptions on an in‐company management development programme

Explores issues arising from an evaluation of a qualification based management development programme run in partnership between Bristol Business School and Chep UK Ltd. Finds the outcomes of the research were important in three ways. First, in providing a greater understanding of stakeholder perceptions of the programme, facilitating modification and improvement. Second, in highlighting the differences between the three major groups of stakeholders within Chep: participants, line managers and board members. Finally, in demonstrating the importance of locating management development initiatives within a clearly developed strategy for organizational change and development. The research was completed in 1993 prior to a major change in the senior management of Chep across Europe and the publication of a strategic plan up to 1998. The views expressed are those of the authors and are not necessarily shared by others.
Who needs restraining? Re-examining the use of physical restraint in an English young offender institution

The use of physical restraint with children in penal custody has been the source of widespread concern following the restraint-related deaths of two teenage boys in 2004. Eleven years later, deep disquiet remains. Drawing upon empirical research conducted in an English young offender institution, this article assesses the key problems associated with the use of restraint and the extent to which forthcoming reforms will address the identified concerns. It argues that, thus far, the treatment of child prisoners has not given appropriate recognition to the status of the child prisoner as a child and independent rights holder with the effect that physical restraint has been used inappropriately, routinely and, in the worst cases, unlawfully, exposing children to harm. Notwithstanding the intended reforms, further legislative, policy and systemic change is required to give primacy to the status of child prisoners as children and fulfil the State's obligations under international human rights law.
Metal Binding to Pseudomonas aeruginosa Azurin: a Kinetic Investigation

The interaction between azurin from Pseudomonas aeruginosa and Ag(I), Cu(II), Hg(II), was investigated as a function of protein state, i.e. apo-, reduced and oxidised azurin. Two different metal binding sites, characterized by two different spectroscopic absorbancies, were detected: one is accessible to Ag(I) and Cu(II) but not to Hg(II); the other one binds Ag(I) and Hg(II) but not copper. When added in stoichiometric amount, Ag(I) shows high affinity for the redox center of apo-azurin, to which it probably binds by the -SH group of Cys112; it can displace Cu(I) from reducedazurin, while it does not bind to the redox center of oxidizedazurin. Kinetic experiments show that Ag(I) binding to the reducedform is four times faster than binding to the apo-form. This result suggests that metal binding requires a conformational rearrangement of the active site of the azurin. Interaction of A g(I) or Hg(II) ions to the second metal binding site, induces typical changes of UV spectrum and quenching of fluorescence emission.
Diffusion of innovation: analysis of internet cellular phone adoption by users in Jordan

This paper draws upon innovation diffusion theory and more recent conceptualisations of mobile internet adoption behaviour. It confirmed the factors in a model developed in the study that were guiding these adoption decisions, including experience of technology and confidence with technology along with the level and source of the respondent's education. Some of the characteristics of the technology that were significant in the decision to adopt were found to be the usability, speed of response, compatibility with other technologies being used by the respondents and security characteristics. An implication for expanding the use of mobile internet applications in Jordan and other Arabic communities is that 'tech-savvy users' will lead adoption if they are provided with secure and usable products.
Cultural transmission of irrelevant tool actions in diffusion chains of 3- and 5-year-old children

We used the diffusion chain method in order to investigate whether irrelevant actions would be transmitted along chains of 3- and 5-year-old children. Four chains of eight children witnessed a trained “expert” child perform a sequence of actions in order to retrieve a reward from either a transparent or an opaque puzzle box. The action sequence involved both goal relevant and goal irrelevant actions. In the transparent box chains the participants could potentially determine which of the actions were irrelevant as the causal effects were clearly visible. Results indicated that irrelevant actions transmitted down chains of 3-year-old children irrespective of box transparency. In contrast, irrelevant actions dropped out of the transparent box chain extremely quickly at 5 years, but were maintained within the opaque chain. These findings highlight the power of the diffusion chain method as a tool for exploring cultural learning.
Family Voices at Mealtime

Infants with visual impairment often require additional interaction from adults to reinforce behaviors that lead to competency at mealtimes, but parental and professional confidence in teaching these skills is often limited. In the following collective case study, the authors, a speech/language pathologist (S/LP), occupational therapist (OT), and a teacher of students with visual impairment (TVI) questioned whether the level of a child’s visual impairment affected child/adult interactions, and if so, how? The authors followed 30 young children with visual impairment from ages 3 months to 3 years. Cases included two groups of participants identified by degree of vision loss. One case had no vision or light perception only and was identified as the Tactual Learners. The other case, identified as the Visual Learners, had some degree of usable vision, but still required some type of adaptation to be successful. Using interpretive observation, semi-structured interviews, and artifacts for triangulation, the authors identified results that indicate young children who have less vision and are Tactual Learners have specific concerns regarding the development of independent eating skills and that a protocol of family-centered mealtime strategies could benefit their parents. The authors independently reviewed and coded the videotapes, interviews, and artifacts to identify four themes to guide additional strategy implementation for families. The research showed improving caretaker confidence, providing adaptations for an individual child’s visual needs, encouraging sensory experiences around food, and teaching developmental expectations can potentially minimize difficulties in establishing good eating habits and promote independence at mealtime.
Regulation of Thromboxane Receptor Signaling at Multiple Levels by Oxidative Stress-Induced Stabilization, Relocation and Enhanced Responsiveness

Background Thromboxane A2 (TxA2) is a major, unstable arachidonic acid metabolite, and plays a key role in normal physiology and control of vascular tone. The human thromboxane receptor (TPβ), expressed in COS-7 cells, is located predominantly in the endoplasmic reticulum (ER). Brief hydrogen peroxide exposure increases the efficiency of translocation of TPβ from the ER into the Golgi complex, inducing maturation and stabilization of TPβ. However, the ultimate fate of this post-ER TPβ pool is not known, nor is its capacity to initiate signal transduction. Here we specifically assessed if functional TPβ was transported to the plasma membrane following H2O2 exposure. Results We demonstrate, by biotinylation and confocal microscopy, that exposure to H2O2 results in rapid delivery of a cohort of TPβ to the cell surface, which is stable for at least eight hours. Surface delivery is brefeldin A-sensitive, indicating that translocation of this receptor cohort is from internal pools and via the Golgi complex. H2O2 treatment results in potentiation of the increase to intracellular calcium concentrations in response to TPβ agonists U46619 and 8-iso PGF2α and also in the loss of ligand-dependent receptor internalization. Further there is increased responsiveness to a second application of the agonist. Finally we demonstrate that the effect of H2O2 on stimulating surface delivery is shared with the FP prostanoid receptor but not the EP3 or EP4 receptors. Conclusions/Significance In summary, brief exposure to H2O2 results in an immediate and sustained increase in the surface pool of thromboxane receptor that is capable of mediating a persistent hyper-responsiveness of the cell and suggests a highly sophisticated mechanism for rapidly regulating thromboxane signaling.
Multiple discriminant analysis of SPECT data for alzheimer's disease, frontotemporal dementia and asymptomatic controls

Multiple discriminant analysis (MDA) is a generalization of the Fisher discriminant analysis (FDA) and makes it possible to discriminate more than two classes by projecting the data onto a subspace. In this work, it was applied to technetium- 99methylcysteinatedimer (99mTc-ECD) SPECT datasets of 10 Alzheimer's disease (AD) patients, 11 frontotemporal dementia (FTD) patients and 11 asymptomatic controls (CTR). Principal component analysis (PCA) was used for dimensionality reduction, followed by projection of the data onto a discrimination plane via MDA. In order to separate the different groups, linear boundaries were calculated by applying FDA to two classes at a time (linear machine). By executing the F-test for different numbers of principal components and examining the corresponding classification accuracy, an optimal discrimination plane based on the first three principal components was determined. In order to further assess the method, another dataset comprising patients with early-onset AD and FTD (beginning or suspected disease) was projected by the same method onto this discrimination plane, resulting in a correct classification for most cases. The successful discrimination of another dataset on the same plane indicates that the model is well suited to account for disease-specific characteristics within the classes, even for patients with early-onset AD and FTD.