Miracle-dz/UniFAR-FTUs huggingface dataset:
Building Communities of Care: A Comprehensive Model for Trauma-Informed Youth Capacity Building and Behavior Management in Residential Services

ABSTRACT Recent efforts to develop residential treatment models have sought to address the need for trauma-informed principles, procedures, and practices. The goal of these efforts is to meet the need for efficient therapeutic residential care that maximizes positive outcomes and minimizes cost for youth and organizations. The article reviews current trauma-informed approaches for residential care, and introduces Building Communities of Care (BCC), a strength-based model that embeds trauma-informed youth capacity building and behavioral management strategies within and across all facets of residential treatment services. Also presented is an evaluation across two programs of the potential contribution of this model to decreased length of stay, utilization of physical restraints, client and personnel injuries, and worker’s compensation claims. The article concludes by highlighting the implications of the BCC model toward more effective residential staff training, youth intervention, and incident reduction, and by discussing future directions for research on trauma-informed program models.
The influence of blinds on temperatures and air flows within ventilated double-skin façades

Ventilated facades have become an increasingly employed feature in the design of low energy buildings over recent years in that they offer the attractive features of a conventional glass facade but without the thermal disadvantages. These facades consist of a double skin surface, the outer layer of which is of toughened glass, and the inner layer of which usually comprises conventional double-glazing, behind which is the occupied space. The cavity formed by the outer and inner layers is ventilated, and frequently contains a blind. This blind, together with the cavity ventilation, provides a means to control the heat transfer across the facade, in terms of solar gain transmission and recovery of heat lost from the interior. A three-year project, funded by the UK’s Engineering and Physical Sciences Research Council (EPSRC), has investigated the thermal and airflow performance of ventilated facades. A series of parametric experiments have been performed using the Large Scale Solar Simulator at Loughborough University. Results from these experiments have been used to validate models of airflow and thermal behaviour developed at De Montfort University. Advice on practical application and industrial practice has been provided by Arup Research and Development and IT Power. The result of the research is an improved understanding of the thermal and air flow behaviour of such ventilated double skin facades. The effects of external conditions, solar irradiation and exterior air temperature, on double skin facades with differing internal characteristics are presented and analysed in this paper. In particular, the effect of the blind blade angle on cavity temperatures and ventilation air flows will be reported, together with an outline of the guidance that is now emerging to assist designers of such facades.
Maximal Flow Through a Network

Introduction. The problem discussed in this paper was formulated by T. Harris as follows: “Consider a rail network connecting two cities by way of a number of intermediate cities, where each link of the network has a number assigned to it representing its capacity. Assuming a steady state condition, find a maximal flow from one given city to the other. ”
Acquired Dyslexia in Three Writing Systems: Study of a Portuguese-Japanese Bilingual Aphasic Patient

The Japanese language is represented by two different codes: syllabic and logographic while Portuguese employs an alphabetic writing system. Studies on bilingual Portuguese-Japanese individuals with acquired dyslexia therefore allow an investigation of the interaction between reading strategies and characteristics of three different writing codes. The aim of this study was to examine the differential impact of an acquired brain lesion on the reading of the logographic, syllabic and alphabetic writing systems of a bilingual Portuguese-Japanese aphasic patient (PF). Results showed impaired reading in the logographic system and when reading irregularly spelled Portuguese words but no effects on reading regular words and nonwords in syllabic and alphabetic writing systems. These dissociations are interpreted according to a multi-route cognitive model of reading assuming selective damage in the lexical route can result in acquired dyslexia across at least three different writing codes.
Collaborative, sequential, and isolated decisions in design

The Massachusetts Institute of Technology (MIT) Commission on Industrial Productivity, in their report Made in America, found that six recurring weaknesses were hampering American manufacturing industries. The two weaknesses most relevant to product development were 1) technological weakness in development and production, and 2) failures in cooperation. The remedies to these weaknesses are considered the essential twin pillars of CE: 1) improved development process, and 2) closer cooperation. In the MIT report, it is recognized that total cooperation among teams in a CE environment is rare in American industry, while the majority of the design research in mathematically modeling CE has assumed total cooperation. In this paper, we present mathematical constructs, based on game theoretic principles, to model degrees of collaboration characterized by approximate cooperation, sequential decision making and isolation. The design of a pressure vessel and a passenger aircraft are included as illustrative examples.
Mediterranean blue tits as a case study of local adaptation

While the study of the origins of biological diversity across species has provided numerous examples of adaptive divergence, the realization that it can occur at microgeographic scales despite gene flow is recent, and scarcely illustrated. We review here evidence suggesting that the striking phenotypic differentiation in ecologically relevant traits exhibited by blue tits Cyanistes caeruleus in their southern range‐edge putatively reflects adaptation to the heterogeneity of the Mediterranean habitats. We first summarize the phenotypic divergence for a series of life history, morphological, behavioural, acoustic and colour ornament traits in blue tit populations of evergreen and deciduous forests. For each divergent trait, we review the evidence obtained from common garden experiments regarding a possible genetic origin of the observed phenotypic differentiation as well as evidence for heterogeneous selection. Second, we argue that most phenotypically differentiated traits display heritable variation, a fundamental requirement for evolution to occur. Third, we discuss nonrandom dispersal, selective barriers and assortative mating as processes that could reinforce local adaptation. Finally, we show how population genomics supports isolation – by – environment across landscapes. Overall, the combination of approaches converges to the conclusion that the strong phenotypic differentiation observed in Mediterranean blue tits is a fascinating case of local adaptation.
Exercise Promotes Axon Regeneration of Newborn Striatonigral and Corticonigral Projection Neurons in Rats after Ischemic Stroke

Newborn striatal neurons induced by middle cerebral artery occlusion (MCAO) can form functional projections targeting into the substantia nigra, which should be very important for the recovery of motor function. Exercise training post-stroke improves motor recovery in clinic patients and increases striatal neurogenesis in experimental animals. This study aimed to investigate the effects of exercise on axon regeneration of newborn projection neurons in adult rat brains following ischemic stroke. Rats were subjected to a transient MCAO to induce focal cerebral ischemic injury, followed by 30 minutes of exercise training daily from 5 to 28 days after MCAO. Motor function was tested using the rotarod test. We used fluorogold (FG) nigral injection to trace striatonigral and corticonigral projection neurons, and green fluorescent protein (GFP)-targeting retroviral vectors combined with FG double labeling (GFP+ -FG+) to detect newborn projection neurons. The results showed that exercise improved the recovery of motor function of rats after MCAO. Meanwhile, exercise also increased the levels of BDNF and VEGF, and reduced Nogo-A in ischemic brain. On this condition, we further found that exercise significantly increased the number of GFP+ -FG+ neurons in the striatum and frontal and parietal cortex ipsilateral to MCAO, suggesting an increase of newborn striatonigral and corticonigral projection neurons by exercise post-stroke. In addition, we found that exercise also increased NeuN+ and FG+ cells in the striatum and frontal and parietal cortex, the ischemic territory, and tyrosine hydroxylase (TH) immunopositive staining cells in the substantia nigra, a region remote from the ischemic territory. Our results provide the first evidence that exercise can effectively enhance the capacity for regeneration of newborn projection neurons in ischemic injured mammalian brains while improving motor function. Our results provide a very important cellular mechanism to illustrate the effectiveness of rehabilitative treatment post-stroke in the clinic.
Mechanisms of Peritoneal B-1a Cells Accumulation Induced by Murine Lupus Susceptibility Locus Sle21

The abundance of B-1a cells found in the peritoneal cavity of mice is under genetic control. The lupus-prone mouse New Zealand Black and New Zealand White (NZB × NZW)F1 and its derivative NZM2410 are among the strains with the highest numbers of peritoneal B1-a cells. We have previously identified an NZM2410 genetic locus, Sle2, which is associated with the production of large numbers of B-1a cells. In this paper, we examined the mechanisms responsible for this phenotype by comparing congenic C57BL/6 mice with or without Sle2. Fetal livers generated more B-1a cells in B6.Sle2 mice, providing them with a greater starting number of B-1a cells early in life. Sle2-expressing B1-a cells proliferated significantly more in vivo than their B6 counterparts, and reciprocal adoptive transfers showed that this phenotype is intrinsic to Sle2 peritoneal B cells. The rate of apoptosis detected was significantly lower in B6.Sle2 peritoneal cavity B-1a cells than in B6, with or without exogenous B cell receptor cross-linking. Increased proliferation and decreased apoptosis did not affect Sle2 peritoneal B-2 cells. In addition, a significant number of peritoneal cavity B-1a cells were recovered in lethally irradiated B6.Sle2 mice reconstituted with B6.Igha bone marrow, showing radiation resistance in Sle2 B-1a cells or its precursors. Finally, B6.Sle2 adult bone marrow and spleen were a significant source of peritoneal B-1a cells when transferred into B6.Rag2−/− mice. This suggests that peritoneal B-1a cells are replenished throughout the animal life span in B6.Sle2 mice. These results show that Sle2 regulates the size of the B-1a cell compartment at multiple developmental checkpoints.
Chapter 0 Can Deterrence Lead to Fairness ?

On the other hand, game theory has its own ethical basis deriving from utilitarian morality, whereby an action cannot be judged by itself, but only its consequences define its moral value. Though Schelling warns the researchers about this simplistic conception of morality, in its most speculative examples, game theory, embraces the definition of utility from the utilitarian tradition. One may argue, as Schelling does, that a moral calculation could be at the foundation of particular allocation of payoff values or could explain why psychological tests strongly diverge from theoretic result; therefore the issue of ethical foundations in game theory is not exhaustively resolved by the utilitarian view. It is nonetheless incontrovertible that game theory has no meaningful applications when the actors are not interested in the consequences of their actions or when the final purpose of a game goes beyond the information comprised in the payoff functions.
Experimental evidence for kin-biased helping in a cooperatively breeding vertebrate

The widespread belief that kin selection is necessary for the evolution of cooperative breeding in vertebrates has recently been questioned. These doubts have primarily arisen because of the paucity of unequivocal evidence for kin preferences in cooperative behaviour. Using the cooperative breeding system of long–tailed tits (Aegithalos caudatus) in which kin and non–kin breed within each social unit and helpers are failed breeders, we investigated whether helpers preferentially direct their care towards kin following breeding failure. First, using observational data, we show that not all failed breeders actually become helpers, but that those that do help usually do so at the nest of a close relative. Second, we confirm the importance of kinship for helping in this species by conducting a choice experiment. We show that potential helpers do not become helpers in the absence of close kin and, when given a choice between helping equidistant broods belonging to kin and non–kin within the same social unit, virtually all helped at the nest of kin. This study provides strong evidence that kinship plays an essential role in the maintenance of cooperative breeding in this species.
Coregulated human globin genes are frequently in spatial proximity when active

The organization of genes within the nucleus may influence transcription. We have analyzed the nuclear positioning of the coordinately regulated α- and β-globin genes and show that the gene-dense chromatin surrounding the human α-globin genes is frequently decondensed, independent of transcription. Against this background, we show the frequent juxtaposition of active α- and β-globin genes and of homologous α-globin loci that occurs at nuclear speckles and correlates with transcription. However, we did not see increased colocalization of signals, which would be expected with direct physical interaction. The same degree of proximity does not occur between human β-globin genes or between murine globin genes, which are more constrained to their chromosome territories. Our findings suggest that the distribution of globin genes within erythroblast nuclei is the result of a self-organizing process, involving transcriptional status, diffusional ability of chromatin, and physical interactions with nuclear proteins, rather than a directed form of higher-order control.
Complement Factor C7 Contributes to Lung Immunopathology Caused by Mycobacterium tuberculosis

Mycobacterium tuberculosis (MTB) remains a significant global health burden despite the availability of antimicrobial chemotherapy. Increasing evidence indicates a critical role of the complement system in the development of host protection against the bacillus, but few studies have specifically explored the function of the terminal complement factors. Mice deficient in complement C7 and wild-type C57BL/6 mice were aerosol challenged with MTB Erdman and assessed for bacterial burden, histopathology, and lung cytokine responses at days 30 and 60 post-infection. Macrophages isolated from C7 −/− and wild-type mice were evaluated for MTB proliferation and cytokine production. C7 −/− mice had significantly less liver colony forming units (CFUs) at day 30; no differences were noted in lung CFUs. The C7 deficient mice had markedly reduced lung occlusion with significantly increased total lymphocytes, decreased macrophages, and increased numbers of CD4+ cells 60 days post-infection. Expression of lung IFN-γ and TNF-α was increased at day 60 compared to wild-type mice. There were no differences in MTB-proliferation in macrophages isolated from wild-type and knock-out mice. These results indicate a role for complement C7 in the development of MTB induced immunopathology which warrants further investigation.
Informed Source Separation Using Iterative Reconstruction

This paper presents a technique for Informed Source Separation (ISS) of a single channel mixture, based on the Multiple Input Spectrogram Inversion (MISI) phase estimation method. The reconstruction of the source signals is iterative, alternating between a time-frequency consistency enforcement and a re-mixing constraint. A dual resolution technique is also proposed, for sharper transients reconstruction. The two algorithms are compared to a state-of-the-art Wiener-based ISS technique, on a database of fourteen monophonic mixtures, with standard source separation objective measures. Experimental results show that the proposed algorithms outperform both this reference technique and the oracle Wiener filter by up to 3 dB in distortion, at the cost of a significantly heavier computation.
The role of cognitive inhibition in emotion regulation: is weak cognitive inhibition related to ruminative style and failed attempts at thought suppression?

Trait rumination is considered a vulnerability factor in major depression (NolenHoeksema, Wisco, & Lyubomirsky, 2008). It has been suggested that rumination is characterized by weak inhibitory processes, which contributes to the uncontrollable nature of negative thoughts thereby increasing risk for depression (Joormann, 2005). However, questions remain on whether the link between inhibition and rumination may be attributed to comorbid depressive symptoms. Therefore, the current study extended previous research by investigating whether ruminative style is associated with deficits in inhibition ability, while controlling for depression status. Furthermore the present dissertation took an initial step by investigating whether inefficient inhibition predict reduced ability to suppress upsetting thoughts during an induced sad mood state. It was hypothesized that high trait rumination would be associated with weak cognitive inhibition, independent of a major depressive disorder, and that weak inhibitory processes characteristic of depressed or high ruminator groups would predict increased intrusions and prolonged sadness follo"":ing thought suppression attempts. Participants (N = 218) completed a list-version directed forgetting task as a measure of cognitive inhibition, and were assigned to suppression or monitor only conditions following a six minute sad movie induction. Thought suppression was measured by number of movie-related thoughts, whereas perceived suppression ability was measured by self-report difficulty ratings for the task. Mood rating scales were administered at four time periods to track reactivity and recovery from induced sad mood. A select group of high and low vulnerability individuals (n =148) with extreme scores on trait rumination were divided into experimental groups (i.e., depressed/high
Long-Term Health Effects of Malaria Exposure around Birth: Evidence from Colonial Taiwan

In the early twentieth century, the Japanese colonial government initiated an island-wide malaria eradication campaign in Taiwan, resulting in not only a rapid decline in malaria across time but also elimination of disparity across regions. Exploiting variations in malaria deaths caused by the campaign, we estimate causal effects of malaria exposure around birth on the health of elderly born in the colonial period. To mitigate potential biases caused by measurement errors and omitted confounders, we employ climatic factors to instrument for malaria deaths. Our findings suggest that people who were exposed to a high malaria risk around birth tend to have a higher likelihood of cardiovascular diseases and worse cognitive functions at old age.
Cloning and Characterization of Muscle-Specific Kinase in Chicken

Muscle-specific kinase (MuSK) is part of the receptor complex that is involved in the agrin-induced formation of the neuromuscular junction. In the rodent, prominent mRNA expression of MuSK is restricted to skeletal muscle while the expression of agrin can also be detected in brain and certain nonneuronal tissues. The recent identification of Xenopus MuSK reveals that MuSK can be detected in tissues other than skeletal muscle, such as the neural tube, eye vesicles, and spleen. In this study, we describe the cloning and characterization of the chicken ortholog of MuSK and demonstrate that the regulation of MuSK expression in muscle is conserved from avian to rodent. Abundant mRNA expression of MuSK can be detected in early embryonic chick muscle and is up-regulated after nerve injury. More importantly, we also demonstrate that, in the chicken, MuSK mRNA is expressed during development in brain and liver, suggesting possible novel functions for MuSK. Furthermore, the regulatory profile of MuSK expression in chick muscle closely parallels that observed for acetylcholine receptor, in terms of both mRNA expression and protein localization. Finally, studies with paralyzed chicken muscle as well as with cultured chick myotubes demonstrate the dependence of MuSK on both electrical activity and trophic factors.
Solving LEGO brick layout problem using Evolutionary Algorithms

LEGO® presented the following problem at the SCAI'01 conference in February 2001: Given any 3D body, how can it be built from LEGO bricks? We apply methods of Evolutionary Algorithms (EA) to solve this optimization problem. For this purpose several specific operators are defined, applied, and their use is compared. In addition, mutation operators with dynamic rate of mutation updated based on their contribution to progress of evolution are proposed. Different population organization strategies are compared. Early results indicate that EA is suitable for solving this hard optimization problem.
The Grammatical Deficits of Persian-Speaking Children with Specific Language Impairment

Background: Specific language impairment (SLI) is one of the most common disorders of language development in children, which has been less addressed in Persian studies. The aim of this study was to evaluate the grammatical characteristics of Persian-speaking children with SLI using Photographic Expressive Persian Grammar Test (PEGT). Methods: This case-control, cross-sectional study was conducted on 16 children with SLI and 16 normal children aged 4-6 years, who were monolingual Persian speakers. The subjects in both groups were age- and gender-matched. After selecting each participant, PEGT was administered and results were recorded in an answer sheet and analyzed. To analyze the data, the mean total scores of the test and mean scores related to each syntactic structure of the PEGT were compared between the two groups using Mann–Whitney test. Results: In this study, a significant difference was observed in mean total scores of the test between the studied groups. In detail, the mean score of the normal group was significantly higher as compared with the SLI group (P<0.05). Moreover, a significant difference was found between the groups regarding each of the evaluated syntactic structures (P<0.05). Conclusion: According to the results of the present study, children with SLI had weaker performance as compared with their normally developing age-matched peers in evaluated morphosyntactic structures.
The human histone chaperone sNASP interacts with linker and core histones through distinct mechanisms

Somatic nuclear autoantigenic sperm protein (sNASP) is a human homolog of the N1/N2 family of histone chaperones. sNASP contains the domain structure characteristic of this family, which includes a large acidic patch flanked by several tetratricopeptide repeat (TPR) motifs. sNASP possesses a unique binding specificity in that it forms specific complexes with both histone H1 and histones H3/H4. Based on the binding affinities of sNASP variants to histones H1, H3.3, H4 and H3.3/H4 complexes, sNASP uses distinct structural domains to interact with linker and core histones. For example, one of the acidic patches of sNASP was essential for linker histone binding but not for core histone interactions. The fourth TPR of sNASP played a critical role in interactions with histone H3/H4 complexes, but did not influence histone H1 binding. Finally, analysis of cellular proteins demonstrated that sNASP existed in distinct complexes that contained either linker or core histones.