Miracle-dz/UniFAR-FTUs huggingface dataset:
Daily use, especially of high-potency cannabis, drives the earlier onset of psychosis in cannabis users.

UNLABELLED Cannabis use is associated with an earlier age of onset of psychosis (AOP). However, the reasons for this remain debated. METHODS We applied a Cox proportional hazards model to 410 first-episode psychosis patients to investigate the association between gender, patterns of cannabis use, and AOP. RESULTS Patients with a history of cannabis use presented with their first episode of psychosis at a younger age (mean years = 28.2, SD = 8.0; median years = 27.1) than those who never used cannabis (mean years = 31.4, SD = 9.9; median years = 30.0; hazard ratio [HR] = 1.42; 95% CI: 1.16-1.74; P < .001). This association remained significant after controlling for gender (HR = 1.39; 95% CI: 1.11-1.68; P < .001). Those who had started cannabis at age 15 or younger had an earlier onset of psychosis (mean years = 27.0, SD = 6.2; median years = 26.9) than those who had started after 15 years (mean years = 29.1, SD = 8.5; median years = 27.8; HR = 1.40; 95% CI: 1.06-1.84; P = .050). Importantly, subjects who had been using high-potency cannabis (skunk-type) every day had the earliest onset (mean years = 25.2, SD = 6.3; median years = 24.6) compared to never users among all the groups tested (HR = 1.99; 95% CI: 1.50- 2.65; P < .0001); these daily users of high-potency cannabis had an onset an average of 6 years earlier than that of non-cannabis users. CONCLUSIONS Daily use, especially of high-potency cannabis, drives the earlier onset of psychosis in cannabis users.
Making Heteronormative Reconciliations

As a central organizing institution in society, marriage presents an idealized package for sociosexual relations that reproduces and intertwines gender power dynamics and heterosexual desire. This package is sustained, in part, by the ideology of romantic love—a set of beliefs that constructs only a particular configuration of sexual and gender practices as natural, normal, and right. Drawing on interviews with 45 people, this study examines how people negotiate marital relationships that do not fit into this normative configuration— mixed-orientation (e.g., straight and gay) marriages. Participants' resolutions to these situations, whether they divorced or created asexual or sexual nonmonogamous marriages, were heavily shaped by their belief in the ideology of romantic love, illustrating how heteronormative relations can be held in place by normalizing ideologies.
Robotic Cell Manipulation Using Optical Tweezers With Unknown Trapping Stiffness and Limited FOV

In existing control methods for optical tweezers, the trapping stiffness is usually assumed to be constant and known exactly. However, the stiffness varies according to the size of the trapped particle and is also dependant on the distance between the center of the laser beam and the particle. It is, therefore, difficult to identify the exact model of the trapping stiffness. In addition, it is also assumed that the entire workspace is visible within the field of view (FOV) of the microscope. During trapping and manipulation, certain image features such as the desired position may leave the FOV, and therefore, visual feedback is not available. In this paper, a robotic setpoint control technique is proposed for optical manipulation with unknown trapping stiffness and limited FOV of the microscope. The proposed method allows the system to operate beyond the FOV and perform trapping and manipulation tasks without any knowledge of the trapping stiffness. The stability of the overall system is analyzed by using Lyapunov-like method, with consideration of the dynamics of both the cell and the manipulator of laser source. Experimental results are presented to illustrate the performance of the proposed method.
Noncontact automatic heart rate analysis in visible spectrum by specific face regions

The current paper presents a comparative study on the influence of different face regions for contactless extraction of the heart rate by computer vision in visible spectrum. A second novelty of our research is the use of Active Appearance Models for computing the shape of the face and of the facial features. Following an experimental setup, we determine that forehead and cheek face regions are more relevant for computing the heart rate. This outcome leads to an optimized face scanning method, faster processing times and better pulse detection results. The findings were implemented in an automatic system prototype for noncontact face analysis. Our methods were tested and validated using video recordings of people in laboratory setup.
Fitting In: Community College Female Executive Leaders Share Their Experiences—A Study in West Texas

Women who move into and work within administration in higher education face many struggles. Both the traits that are specific to most females and their leadership style can impede their rise into and within administrative ranks. In addition, higher education has traditionally been a hierarchical and patriarchal system that makes it more difficult for women to advance into administrative positions. Over the past few decades, women have been making significant increases in community college administration. Community colleges have been more accepting of women both as students and as faculty; and now, they are leading higher education in reaching gender parity in administration. Across the nation, women hold over 50 percent of the executive/administrative and managerial positions in community colleges. In contrast to the national numbers, women in West Texas are in the minority as administrators in community colleges. Using a naturalistic inquiry and case study format, this study investigated environmental factors in West Texas community colleges that contribute to the marginalization of four women in leadership roles. In addition, the study also investigated the perceived leadership style and the mentorship opportunities of these women. This research gives access to the success stories of women in community college administration. The stories of these women serve as models for other women wanting to move into the administrative ranks of community colleges.
Metadata as a Catalyst: Experiments with Metadata and Search Engines in the Internet Journal, First Monday

This study examines metadata as a means to enhance information retrieval in a suite of seven search engines, AltaVista, Excite, Google, HotBot, InfoSeek, Lycos, and Northern Light. Papers were selected from issues of the Internet-only journal First Monday, and examined by portions of author and title in seven search engines, without metadata. Metatags were then added to these papers and the searches were repeated five months later. Metadata alone did not play a significant role in increasing the likelihood of a given paper being indexed or highly ranked by any specific search engine.
Multiple treatment interference in the alternating treatments design as a function of the intercomponent interval length.

In experimental designs requiring the administration of more than one treatment to the same subject(s), the effect of one treatment may be influenced by the effect of another treatment (Campbell & Stanley, 1963), a phenomenon known as multiple treatment interference. We conducted two studies in which multiple treatment interference in an alternating treatments design was shown to be a function of the length of the intercomponent interval (ICI) separating treatment conditions. In the first study, we evaluated the effects of four different treatments on the mouthing of a severely retarded boy. Under a 1-min ICI no consistent differential responding to treatment was obtained. Differential responding emerged when the ICI was increased from 1 min to 120 min, thus suggesting multiple treatment interference in the lack of differential responding under a 1-min changeover interval. Functional control of the nondifferential and differential responding as a function of the ICI length was replicated in a reversal phase. In the second study, we compared two treatment procedures for the disruptive noncompliant behavior of a moderately retarded boy. Multiple treatment interference (i.e., the lack of differential responding) occurred with the 1-min intercomponent interval. An increase to a 120-min ICI again resulted in differential responding. A replication of multiple treatment interference by a reversal to a short interval phase was not achieved in the second subject. Results of this study support much of the basic literature on discrimination and multiple treatment interference. (ABSTRACT TRUNCATED AT 250 WORDS)
The role of cardiac rehabilitation in influencing psychological outcomes

Anxiety and depression are common after acute cardiac events. They can have a major adverse impact upon outcomes, although past studies report conflicting results regarding the relationships between anxiety, depression and outcomes such as mortality. Depression has been shown to be associated with non-adherence of patients. Cardiac rehabilitation programmes conducted during early convalescence provide a valuable opportunity to identify and support patients who experience anxiety and depression, and encourage adherence to advice. Clinical data support the positive effects upon patients' psychological outcomes of cardiac rehabilitation programmes offering group exercise, education and behavioural interventions. However, more rigorous research is required to confirm such benefits. Systematic screening of patients should be undertaken on entry to cardiac rehabilitation to identify high-risk patients and to assist them. Copyright © 2008 John Wiley & Sons, Ltd.
SHH inhibitors for the treatment of medulloblastoma

Medulloblastoma is the most common malignant brain tumor of childhood. It is currently stratified into four molecular variants through the advances in transcriptional profiling. They include: wingless, sonic hedgehog (SHH), Group III, and Group IV. The SHH group is characterized by constitutive activation of the SHH signaling pathway, and genetically characterized by mutations in patched homolog 1 (PTCH1) or other downstream pathway mutations. SHH inhibitors have become of great clinical interest in treating SHH-driven medulloblastoma. Many inhibitors are currently in different stages of development, some already approved for other SHH-driven cancers, such as basal cell carcinoma. In vitro and in vivo medulloblastoma studies have shown efficacy and these findings have been translated into Phase I and II clinical trials. In this review, we present an overview of SHH medulloblastoma, as well as a discussion of currently available SHH inhibitors, and the challenges associated with their use.
Demonstration of binding of dengue virus envelope protein to target cells

The nature of the initial interaction of dengue virus with target cells and the extent to which this interaction defines tropism are unknown. Infection of some cells may involve antidengue antibody-mediated immune adherence to cells bearing immunoglobulin Fc receptors; however, this mechanism does not explain primary infection or the infection of cells without Fc receptors. We hypothesized that dengue virus envelope protein mediates initial binding to target cells. To test this hypothesis, a recombinant chimeric form of dengue type 2 virus envelope protein was used as a probe to investigate binding to the surfaces of potential target cells. Envelope protein was expressed amino terminal to the heavy-chain constant region of human immunoglobulin G containing the Fc receptor binding motif; the binding mediated by envelope determinants was distinguishable from the binding mediated by immunoglobulin Fc determinants. We found that the recombinant chimera bound to Vero, CHO, endothelial, and glial cells through envelope protein determinants and to monocytes and U937 cells by Fc-Fc receptor interactions. The highest level of binding was to Vero cells; binding was dose and time dependent and saturable. Examination of partial-length recombinant envelope proteins indicated that the binding motif was expressed between amino acids 281 and 423. Recombinant envelope protein inhibited infection of Vero cells by dengue virus, indicating the functional significance of the interaction of envelope protein and target cells in infectivity. These results suggest that envelope protein binding to a non-Fc receptor could explain the cell and tissue tropism of primary dengue virus infection.
Politeness and the Perception of Irony: Honorifics in Japanese

The purpose of this study was to investigate the use in the Japanese language of honorifics (a system of politeness expressions incorporated into the grammar) on the perception of irony in assertives. In Experiment 1, the contents (positive and incongruent with facts vs. negative and congruent with facts) and the style (honorific vs. nonhonorific) were manipulated in utterances directed to addressees to whom the use of honorifics was overpolite. Honorific utterances were judged to be more ironic than nonhonorific ones only when their contents were negative. In Experiment 2, the status relationship between the communicators as well as the style was manipulated. Utterances directed to lower-status addressees were taken to be more ironic when they contained honorifics (overpolite). Those directed to high-status addressees were, however, taken to be more ironic when they did not contain any honorifics (impolite). The results of the 2 experiments suggested that the divergence of politeness levels in either direction (i.e., overpolite or impolite) heightens the perception of irony through pragmatic insincerity.
Ovulation and risk of epithelial ovarian cancer

Incessant ovulation is thought to be one of the primary causes of epithelial ovarian cancer. However, the effects of ovulation at different ages and of the various exposures or events that suppress ovulation have not been established. We used data from an Australian case‐control study of 791 ovarian cancer cases and 853 controls to examine the effect of ovulation on ovarian cancer risk. The total number of lifetime ovulations was calculated using information provided in a monthly contraceptive/reproductive calendar, as well as incorporating other information such as average menstrual cycle length. An increase of 1 year's worth of ovulation was associated with a 6% increase in risk of ovarian cancer (95% confidence interval [CI] = 4–8%). Ovulations in the 20–29‐year age group were associated with the greatest risk, with a 20% increase in risk associated with each year of ovulation during this age period (95% CI = 13–26%). When the effects of different exposures that suppress ovulation were compared, there was an indication that some factors may have a greater effect than others. These findings support the theory that incessant ovulation is a major contributor to the occurrence of ovarian cancer and suggest that ovulations during the 20s may be those most associated with disease risk. © 2003 Wiley‐Liss, Inc.
Extreme right foot soldiers, legacy effects and deprivation

Despite a vast pan-European literature on extreme right parties (ERPs), few studies speak convincingly to questions of party membership and activism. This article draws on a unique membership dataset to examine contextual predictors of membership of the British National Party (BNP), currently the dominant representative of the extreme right in British politics. We operationalize and test for the impact of both demand-side and supply-side factors, including the seldom examined effects of historical legacies, and of party activism and electoral success on membership levels. Aside from congregating in urban areas that are more deprived and have low education levels, we also find evidence of a ‘legacy effect’, whereby membership levels are higher in areas with a historic tradition of extreme right activism. This research is the first ever systematic investigation of national extreme right party membership.
Bilateral and multiple mixed epithelial and stromal tumors of the kidney: A case report

Mixed epithelial and stromal tumor (MEST) of the kidney is a benign tumor occurring predominantly in older women. Histologically, MEST comprises tubuloglandular and cystic structures in an ovarian-like stroma. Bilateral and multiple cases are rare. We herein present a case of bilateral and multiple MEST in a 43-year-old woman. The patient presented with gross hematuria and was referred to a primary care physician. A computed tomography scan revealed 5 tumors in the right and 2 in the left kidney. Renal cell carcinoma was suspected, and left partial nephrectomy followed by right radical nephrectomy was planned. After the left partial nephrectomy, the histopathological diagnosis was MEST, which was consistent with the results obtained following needle biopsy. Therefore, the contralateral tumor was also suspected to be MEST, and needle biopsy was performed. The histopathological diagnosis was identical and the right kidney was spared. The patient is currently periodically monitored. As MEST is a benign tumor, preoperative diagnosis is crucial for avoiding overtreatment.
The Peculiar Periodic YSO WL 4 in ρ Ophiuchus

We present the discovery of 130.87 day periodic near-infrared flux variability for the Class II T Tauri star WL 4 (=2MASS J16271848–2429059, ISO-Oph 128). Our data are from the 2MASS Calibration Point Source Working Database and constitute 1580 observations in J, H, and Ks of a field in ρ Ophiuchus used to calibrate the 2MASS All-Sky Survey. We identify a light curve for WL 4 with eclipse amplitudes of ~0.4 mag lasting more than one-quarter the period and color variations in J–H and H–Ks of ~0.1 mag. The long period cannot be explained by stellar rotation. We propose that WL 4 is a triple YSO system, with an inner binary orbital period of 130.87 days. We posulate that we are observing each component of the inner binary alternately being eclipsed by a circumbinary disk with respect to our line of sight. This system will be useful in investigating terrestrial-zone YSO disk properties and dynamics at ~1 Myr.
The role of attention in retrieval practice

Whiffen, Joshua W. M.S., Purdue University, May 2015. The Role of Attention in Retrieval Practice. Major Professor: Jeffrey D. Karpicke. Dividing attention during encoding is detrimental to learning. In contrast, dividing attention during retrieval appears to have very little effect on recall. However, very few studies have investigated whether dividing attention during initial recall has an impact on subsequent retrieval attempts. Research on retrieval practice has clearly shown that retrieval is an active process that leads to important changes in memory that ultimately enhance long term retention. However, it has yet to be established exactly how retrieval practice derives its benefits. One possibility is that retrieval involves the reinstatement of temporal context, which leads to the updating or encoding of additional context features that can ultimately be used during a later retrieval attempt to help restrict the search set and retrieve the target memory. If this perspective is correct then certain predictions can be made about the influence that dividing attention may have on retrieval practice. Specifically, dividing attention is known to disrupt encoding process, thus dividing attention may disrupt updating of additional context features and therefore prevent the encoding of additional context features. This should then reduce the mnemonic
Selection Bias Related To Parental Consent in School-Based Survey Research

The authors examined differences between students with and without written parental consent to take part in a sensitive health survey. The data were collected using a consent procedure combining "active" and "passive" response options. Two thousand seven hundred five 9th and 12th graders whose parents provided written consent completed a full survey. An identical survey, without sex-related questions, was completed by 3,533 students whose parents gave "passive" consent to this less sensitive version. Students with written consent were more likely to be White, to live in two-parent households, to have a grade point average of B or above, and to be involved in extracurricular activities. They were also more likely to have been exposed to health promotion interventions. Irregular seat belt use was lower in the written-consent group at both grade levels. Among 9th graders, cigarette smoking was less prevalent in the written-consent group. There were no significant differences in alcohol or illicit drug use.
Factors associated with intradialytic systolic blood pressure variability.

BACKGROUND Although blood pressure lability during hemodialysis has long been recognized, little is known about factors that promote nonsystematic intradialytic blood pressure variability. STUDY DESIGN Prospective observational cohort. SETTING & PARTICIPANTS Random cluster sample of 218 prevalent hemodialysis patients treated at 5 participating DaVita Dialysis units. PREDICTORS Clinical variables that may plausibly influence intradialytic systolic blood pressure (SBP) variability. OUTCOMES SBP variability as described by: (1) the deviation of SBP from its anticipated course (primary metric) and (2) the absolute value of the difference between successive SBP measurements (secondary metric). MEASUREMENTS SBPs measured and recorded (n = 19,170) per clinical protocol during hemodialysis treatments (n = 2,422; median 11 per patient) occurring in the first 30 days of study. Predictors were assessed through standardized interview, examination, and medical record abstraction. RESULTS Results were similar when SBP variability was considered in terms of the primary and secondary metrics. Older age and longer dialysis vintage were associated with increased SBP variability, whereas other patient characteristics were not. Greater fluid removal during hemodialysis (whether considered as volume or rate either absolute or relative to total-body water) was associated with greater SBP variability independently of its effects on net pre- to posttreatment SBP reduction. Neither number nor dialyzability of antihypertensive medications nor individual classes of agents showed an association with SBP variability. LIMITATIONS Over-representation of African Americans and patients with congestive heart failure; observational design; use of clinically measured blood pressures; absence of medication adherence confirmation. CONCLUSIONS Increased intradialytic SBP variability is associated with greater dialytic fluid removal and rate, as well as demographic characteristics, such as older age and dialysis vintage. Further work is needed to confirm these findings and measure associations between SBP variability and clinical outcomes.
On the Precoder Design of Flat Fading MIMO Systems Equipped With MMSE Receivers: A Large-System Approach

This paper is devoted to the design of precoders maximizing the ergodic mutual information (EMI) of bi-correlated flat fading MIMO systems equipped with MMSE receivers. The channel state information and the second-order statistics of the channel are assumed available at the receiver side and at the transmitter side respectively. As the direct maximization of the EMI needs the use of nonattractive algorithms, it is proposed to optimize an approximation of the EMI, introduced recently, obtained when the number of transmit and receive antennas t and τ converge to ∞ at the same rate. It is established that the relative error between the actual EMI and its approximation is a O( [ 1/( t2)]) term. It is shown that the left singular eigenvectors of the optimum precoder coincide with the eigenvectors of the transmit covariance matrix, and its singular values are solution of a certain maximization problem. Numerical experiments show that the mutual information provided by this precoder is close from what is obtained by maximizing the true EMI, but that the algorithm maximizing the approximation is much less computationally intensive.