Miracle-dz/UniFAR-FTUs huggingface dataset:
Influence of Different Doses of Ketamine on Intubating Conditions during a Rapid Sequence Induction and Intubation Model.

OBJECTIVE This prospective, randomized, double-blinded study aimed to compare the effects of three different doses of ketamine or lidocaine on intubating conditions and haemodynamics in a rapid-sequence induction model with 3 mg kg(-1) propofol and 0.6 mg kg(-1) rocuronium. METHODS A total of 128 ASA I-III patients who were scheduled for elective surgery were randomized in the following five groups: Group 1 (n=24), 1 mg kg(-1) lidocaine+3 mg kg(-1) propofol+0.6 mg kg(-1) rocuronium; Group 2 (n=23), 0.1 mg kg(-1) ketamine+3 mg kg(-1) propofol+0.6 mg kg(-1) rocuronium; Group 3 (n=29), 0.3 mg kg(-1) ketamine+3 mg kg(-1) propofol+0.6 mg kg(-1) rocuronium; Group 4 (n=26), 0.5 mg kg(-1) ketamine+3 mg kg(-1) propofol+0.6 mg kg(-1) rocuronium and Group 5 (n=26), 3 mg kg(-1) propofol+0.6 mg kg(-1) rocuronium+saline as placebo. After preoxygenation, induction was performed with the assigned combination, and intubation was initiated after 60 s. The time to intubation, intubation score (Viby-Mogensen score) and haemodynamic data were recorded. Postoperative hoarseness, sore throat and hallucination incidences were followed up. RESULTS Demographic, time to intubation and haemodynamic data were comparable among groups. Group 4 [13.5 (4-14)] revealed a higher intubation score then groups 1, 2 and 5 [12 (3-14), 11 (2-14) and 9.5 (0-13) and p=0.026, p=0.001 and p=0.000001, respectively]. Groups 3 [13 (4-14)] and 4 [13.5 (4-14)] had similar intubation scores. Side effects were comparable among all groups. CONCLUSION The combination of 0.5 mg kg(-1) ketamine and 0.6 mg kg(-1) rocuronium along with propofol improves intubation conditions in a stimulated rapid-sequence induction model.
Expanding the clinicopathologic spectrum of palisaded encapsulated neuroma

Palisaded encapsulated neuroma (PEN; solitary circumscribed neuroma) is a benign, morphologically characteristic cutaneous or mucosal neuroma. Most are solitary lesions on the face, neck or oral mucosa. Histologically, the majority appears as dermal nodules of Schwann cell‐rich fascicles, with or without distinctive encapsulation. To further expand on the existing literature regarding this neuroma, we herein describe three PENs with unique clinical and histopathologic features. All occurred on the acral skin, a rarely described site. Furthermore, one exceptional patient presented with multiple PEN on the bilateral hands, biopsies of which showed a prominent plexiform architecture. Awareness that PEN may occur on acral skin, may rarely present as multiple lesions, and recognition of the plexiform variant is important because PEN may histologically mimic other peripheral nerve sheath tumors. Additionally, misdiagnosis may have significant clinical implications.
STRETCH REFLEX INTERACTIONS STUDIED WITH THE AID OF SIMULATION

Analysis of the mechanisms of neural control of movement and posture has remained an exceedingly difficult task. Even the stretch reflex involves the interaction of a series of parts, each one of which shows individually a complex dynamic behavior. The response of the whole stretch reflex to a variety of stretch inputs has been extensively documented since the early studies of Liddell and Sherrington (17). The literature on studies of characteristics of the fibers and the monosynaptic reflex pathway which are the chief neural components of the stretch reflex, are too extensive to document. The effector organ, the muscle, is also one of the oldest and most extensively studied physiological topics. Even the stretch receptor has been studied extensively since the early work of Adrian and of Matthews (1, 2, 21). In spite of this wealth of information about the performance of the parts of the stretch reflex, it appears that the over-all response of a stretch reflex to some particular stimulus has not been explained by combining the effects of the parts. In a reflex tension response to a static stretch no particular difficulty exists in such a synthetic analysis even though the parts are non-linear. However, normal responses involve changing input stretches and thus require the added consideration of the dynamic response characteristics of the parts. Thus adaptation in the receptor and wave summation in the muscle would affect the course of the response to a given stimulus. The complications of having to consider several sequential dynamic effects have discourgaed the synthetic approach to the analysis of this reflex. Since the stretch reflex is involved in movement and posture systems, such an elementary synthesis is an essential step toward the development of a similar analysis of the more complex system. In the present study, mostly linear, approximate simulations of several of the dynamic characteristics of parts of the stretch reflex have been developed using analog computer simulation techniques. By adjustment of the time constants and amplitude coefficients in the simulation to match values taken from published animal records it is possible to obtain qualitative and quantitative estimates of the nature of the dynamic effects these same parameters should introduce into the animal reflex. Unlike mathematical analysis of such systems the simu-
Sphingosine phosphate lyase regulates myogenic differentiation via S1P receptor‐mediated effects on myogenic microRNA expression

S1P lyase (SPL) catalyzes the irreversible degradation of sphingosine‐1‐phosphate (S1P), a bioactive lipid whose signaling activities regulate muscle differentiation, homeostasis, and satellite cell (SC) activation. By regulating S1P levels, SPL also controls SC recruitment and muscle regeneration, representing a potential therapeutic target for muscular dystrophy. We found that SPL is induced during myoblast differentiation. To investigate SPL's role in myogenesis at the cellular level, we generated and characterized a murine myoblast SPL‐knockdown (SPL‐KD) cell line lacking SPL. SPL‐KD cells accumulated intracellular and extracellular S1P and failed to form myotubes under conditions that normally stimulate myogenic differentiation. Under differentiation conditions, SPL‐KD cells also demonstrated delayed induction of 3 myogenic microRNAs (miRNAs), miR‐1, miR‐206, and miR‐486. SPL‐KD cells successfully differentiated when treated with an S1P1 agonist, S1P2 antagonist, and combination treatments, which also increased myogenic miRNA levels. SPL‐KD cells transfected with mimics for miR‐1 or miR‐206 also overcame the differentiation block. Thus, we show for the first time that the S1P/SPL/S1P‐receptor axis regulates the expression of a number of miRNAs, thereby contributing to myogenic differentiation. —de la Garza‐Rodea, A. S. , Baldwin, D. M. , Oskouian, B. , Place, R. F. , Bandhuvula, P., Kumar, A. , Saba, J. D. Sphingosine phosphate lyase regulates myogenic differentiation via S1P receptor‐mediated effects on myogenic microRNA expression. FASEB J. 28, 506–519 (2014). www.fasebj. org
Fast and cloning‐free CRISPR/Cas9‐mediated genomic editing in mammalian cells

CHoP-In (CRISPR/Cas9-mediated, Homology-independent, PCR-product Integration) is a fast and cloning-free strategy for genomic editing of mammalian cells. The desired integration fragment is produced as a PCR product, flanked by the Cas9 recognition sequences of the target locus. When co-transfected with the cognate Cas9/guide RNA, double strand breaks are introduced at the target genomic locus and at both ends of the PCR product. This allows incorporation into the genomic locus via hon-homologous end joining. The approach is versatile, allowing N-terminal, C-terminal or internal tag integration and gives predictable genomic integrations, as demonstrated for a selection of key membrane trafficking proteins. The lack of any donor vectors offers advantages over existing methods in terms of both speed and hands-on time. As such this approach will be a useful addition to the genome editing toolkit of those working in mammalian cell systems.
Bilinear CNNs for Fine-grained Visual Recognition

We present a simple and effective architecture for fine-grained visual recognition called Bilinear Convolutional Neural Networks (B-CNNs). These networks represent an image as a pooled outer product of features derived from two CNNs and capture localized feature interactions in a translationally invariant manner. B-CNNs belong to the class of orderless texture representations but unlike prior work they can be trained in an end-to-end manner. Our most accurate model obtains 84.1%, 79.4%, 86.9% and 91.3% per-image accuracy on the Caltech-UCSD birds [67], NABirds [64], FGVC aircraft [42], and Stanford cars [33] dataset respectively and runs at 30 frames-per-second on a NVIDIA Titan X GPU. We then present a systematic analysis of these networks and show that (1) the bilinear features are highly redundant and can be reduced by an order of magnitude in size without significant loss in accuracy, (2) are also effective for other image classification tasks such as texture and scene recognition, and (3) can be trained from scratch on the ImageNet dataset offering consistent improvements over the baseline architecture. Finally, we present visualizations of these models on various datasets using top activations of neural units and gradient-based inversion techniques. The source code for the complete system is available at this http URL.
Large scale deletions in the GPC3 gene may account for a minority of cases of Simpson-Golabi-Behmel syndrome.

AIMS OF THE STUDY: To identify the proportion and type of deletions present in the glypican 3 (GPC3) gene in a group of patients with Simpson-Golabi-Behmel syndrome (SGBS). SUBJECTS AND METHODS: PCR analysis using primer pairs which amplify fragments from each of the eight exons of the GPC3 gene was carried out in a series of 18 families with SGBS (approximately half of reported cases). RESULTS: Deletions were detected in only five families (one reported previously). We found deletions in all exons of the gene except exon 3. CONCLUSIONS: Our results suggest that large scale deletions may be less common in SGBS than was originally thought. One patient, with an exon 4 and 5 deletion, lacked the characteristic facial dysmorphic features. This raises the possibility of involvement of GPC3 gene defects in a wider range of overgrowth disorders.
Alternative geographic adjustments in Medicare payment to health maintenance organizations

The payment received by a health maintenance organization (HMO) for its Medicare enrollees is proportionate to the average cost of Medicare beneficiaries in that county. However, HMO market share in an area appears to decrease costs in the fee-for-service sector, so that HMOs are paid less. For this and other reasons, alternative payment formulas may be desirable and several are developed in this article. The conceptually simplest location factor would be an input price index. An alternative strategy would also recognize systematic variation in utilization. Utilization rate is regressed on variables such as county population density and physicians per 1,000 persons. The predicted utilization rate times an input price index could serve as a location factor. The value of alternative location factors are presented for specific counties.
Microarray detection of human papilloma virus genotypes among Turkish women with abnormal cytology at a colposcopy unit.

OBJECTIVE There is a well-known association between human papilloma virus (HPV) and cervical neoplasia. The aim of this study was to investigate the types of HPV DNA and to compare the results with colposcopic findings among women with abnormal cytology. MATERIAL AND METHODS A series of 76 consecutive women attending the clinic with the usual referral indications (ASC-US or higher in Pap) were examined by the conventional diagnostic tools (PAP smear, colposcopy,punch biopsy) and subjected to HPV testing. For HPV genotyping, we used a commercially avaliable HPV DNA chip (Genomica-CLART) which is a PCR based microarray system.The HPV test detected 35types of HPV (HPV-6/-11/-16/-18/-26/-31/-33/-35/-39/-40/-42/-43/-44/-45/-51/-52/-53/-54/-56/-58/-59/-61/-62/-66/-70/-71/-72/-73/-81/-83/84/-85/-89). RESULTS Overall, 44.7% of all patients were HPV positive. HPV was positive in 35%, 51.9%, 77.7% of the ASCUS, LSIL and HSIL groups respectively and HPV 16 was the most prevalent type in all groups. 6 %of patients had mutiple infections. 57.8% of biopsy proven SIL's were HPV positive. The most prevalent HPV type was HPV 16 (54.5%). Colposcopic assessment revealed pathologic findings in 94.7% of biopsy proven SIL cases. CONCLUSION Although it has been reported that the prevalence of HPV in the general population is lower than Western countries, and the prevalence and distribution of genotypes are smilar in patients with abnormal cytology. Further population based studies are needed to determine the prevalance and type distribution of HPV with normal and abnormal cytology in Turkish women. Despite the new technological progress in HPV virion, colposcopy is still very important diagnostic tool in the management of abnormal smears.
SYSTEMATIC DETAILED DESIGN OF UNEQUAL-SPLIT 3-WAY BAGLEY POWER DIVIDERS USING UNIFORM TRANSMISSION LINES

In this paper, we systematically derive design equations for 3-way Bagley power dividers with arbitrary split ratios using interconnecting transmission lines with the same characteristic impedance. The exact value of the characteristic impedance for a specific dividing ratio is determined using these equations to achieve perfect input port matching. To validate the design procedure, two microstrip dividers with different split ratios, 1 : 3 : 1 and 1 : 10 : 1, are designed, simulated, fabricated, and measured. The desired split ratios are achieved at the design frequency, 1 GHz. Good agreement between simulated and measured results is obtained.
Genomic reaction norms: using integrative biology to understand molecular mechanisms of phenotypic plasticity

Phenotypic plasticity is the development of different phenotypes from a single genotype, depending on the environment. Such plasticity is a pervasive feature of life, is observed for various traits and is often argued to be the result of natural selection. A thorough study of phenotypic plasticity should thus include an ecological and an evolutionary perspective. Recent advances in large‐scale gene expression technology make it possible to also study plasticity from a molecular perspective, and the addition of these data will help answer long‐standing questions about this widespread phenomenon. In this review, we present examples of integrative studies that illustrate the molecular and cellular mechanisms underlying plastic traits, and show how new techniques will grow in importance in the study of these plastic molecular processes. These techniques include: (i) heterologous hybridization to DNA microarrays; (ii) next generation sequencing technologies applied to transcriptomics; (iii) techniques for studying the function of noncoding small RNAs; and (iv) proteomic tools. We also present recent studies on genetic model systems that uncover how environmental cues triggering different plastic responses are sensed and integrated by the organism. Finally, we describe recent work on changes in gene expression in response to an environmental cue that persist after the cue is removed. Such long‐term responses are made possible by epigenetic molecular mechanisms, including DNA methylation. The results of these current studies help us outline future avenues for the study of plasticity.
Carbonyl Sulfide-Mediated Prebiotic Formation of Peptides

Almost all discussions of prebiotic chemistry assume that amino acids, nucleotides, and possibly other monomers were first formed on the Earth or brought to it in comets and meteorites, and then condensed nonenzymatically to form oligomeric products. However, attempts to demonstrate plausibly prebiotic polymerization reactions have met with limited success. We show that carbonyl sulfide (COS), a simple volcanic gas, brings about the formation of peptides from amino acids under mild conditions in aqueous solution. Depending on the reaction conditions and additives used, exposure of α-amino acids to COS generates peptides in yields of up to 80% in minutes to hours at room temperature.
Functional Subdomains within Human FFA

The fusiform face area (FFA) is a well-studied human brain region that shows strong activation for faces. In functional MRI studies, FFA is often assumed to be a homogeneous collection of voxels with similar visual tuning. To test this assumption, we used natural movies and a quantitative voxelwise modeling and decoding framework to estimate category tuning profiles for individual voxels within FFA. We find that the responses in most FFA voxels are strongly enhanced by faces, as reported in previous studies. However, we also find that responses of individual voxels are selectively enhanced or suppressed by a wide variety of other categories and that these broader tuning profiles differ across FFA voxels. Cluster analysis of category tuning profiles across voxels reveals three spatially segregated functional subdomains within FFA. These subdomains differ primarily in their responses for nonface categories, such as animals, vehicles, and communication verbs. Furthermore, this segregation does not depend on the statistical threshold used to define FFA from responses to functional localizers. These results suggest that voxels within FFA represent more diverse information about object and action categories than generally assumed.
Effect of Antioxidant Vitamin Supplementation on Cardiovascular Outcomes: A Meta-Analysis of Randomized Controlled Trials

Background Antioxidant vitamin (vitamin E, beta-carotene, and vitamin C) are widely used for preventing major cardiovascular outcomes. However, the effect of antioxidant vitamin on cardiovascular events remains unclear. Methodology and Principal Findings We searched PubMed, EmBase, the Cochrane Central Register of Controlled Trials, and the proceedings of major conferences for relevant literature. Eligible studies were randomized controlled trials that reported on the effects of antioxidant vitamin on cardiovascular outcomes as compared to placebo. Outcomes analyzed were major cardiovascular events, myocardial infarction, stroke, cardiac death, total death, and any possible adverse events. We used the I2 statistic to measure heterogeneity between trials and calculated risk estimates for cardiovascular outcomes with random-effect meta-analysis. Independent extraction was performed by two reviewers and consensus was reached. Of 293 identified studies, we included 15 trials reporting data on 188209 participants. These studies reported 12749 major cardiovascular events, 6699 myocardial infarction, 3749 strokes, 14122 total death, and 5980 cardiac deaths. Overall, antioxidant vitamin supplementation as compared to placebo had no effect on major cardiovascular events (RR, 1.00; 95%CI, 0.96–1.03), myocardial infarction (RR, 0.98; 95%CI, 0.92–1.04), stroke (RR, 0.99; 95%CI, 0.93–1.05), total death (RR, 1.03; 95%CI, 0.98–1.07), cardiac death (RR, 1.02; 95%CI, 0.97–1.07), revascularization (RR, 1.00; 95%CI, 0.95–1.05), total CHD (RR, 0.96; 95%CI, 0.87–1.05), angina (RR, 0.98; 95%CI, 0.90–1.07), and congestive heart failure (RR, 1.07; 95%CI, 0.96 to 1.19). Conclusion/Significance Antioxidant vitamin supplementation has no effect on the incidence of major cardiovascular events, myocardial infarction, stroke, total death, and cardiac death.
It's Not Easy Going Green: Obstacles to Tree- Planting Programs in East Baltimore

In 2006, government officials in Baltimore announced plans to double the city's tree canopy over the next thirty years. While the effort has already produced positive results, many parts of the city still lack trees. In this paper we consider whether two neighborhoods in East Baltimore  Berea and Madison-Eastend  are suitable locations for tree planting. We begin by calculating how much plantable space exists in each neighborhood. We then use interview data to cast light on how residents value the urban forest and whether or not they would support efforts to increase tree canopy in East Baltimore. The selection of East Baltimore as a study area is significant because it was here that the city's Division of Forestry encountered resistance to tree planting in the 1960s. A secondary goal of our research is to determine whether a shift in the ethnic profile of this section of the city over the past fifty years has changed the way residents perceive and value the urban forest. Our results show that while there is enough plantable space in these two neighborhoods to increase tree canopy, from approximately six percent to over 16 percent, residents are not yet ready to fully embrace an aggressive tree planting program.
Empirical Studies of Financial Innovation: Lots of Talk, Little Action?

This paper reviews the extant empirical studies of financial innovation. Adopting broad criteria, the authors found just two dozen studies, over half of which (fourteen) had been conducted since 2000. Since some financial innovations are examined by more than one study, only fourteen distinct phenomena have been covered. Especially striking is the fact that only two studies are directed at the hypotheses advanced in many broad descriptive articles concerning the environmental conditions (e.g., regulation, taxes, unstable macroeconomic conditions, and ripe technologies) spurring financial innovation. The authors offer some tentative conjectures as to why empirical studies of financial innovation are comparatively rare. Among their suggested culprits is an absence of accessible data. The authors urge financial regulators to undertake more surveys of financial innovation and to make the survey data more available to researchers.
Multimodality vascular imaging in CKD: divergence of risk between measured parameters.

BACKGROUND High cardiovascular risk in chronic kidney disease (CKD) patients appears only partly attributable to atherosclerosis, with much of the remaining risk being ascribed to other vasculature abnormalities, including endothelial dysfunction, arterial stiffness and vascular calcification (VC). To date, these factors have been primarily studied in isolation or in dialysis patients. This study performed a global vascular assessment in moderate CKD and assessed the relationships with both traditional and novel risk factors. METHODS This was a prospective cross-sectional analysis of 120 patients (age 60 ± 10 years; estimated glomerular filtration rate 25-60 mL/min/1.73m(2)). Demographic, clinical and biochemical characterization was performed. VC was characterized by lateral lumbar radiograph; arterial stiffness by aortic pulse-wave velocity (PWV); atheroma burden by carotid intima-media thickness (cIMT) and endothelial function by flow-mediated dilation (FMD) of the brachial artery. RESULTS VC was highly prevalent (74%), and FMD generally poor (FMDΔ 3.3 ± 3.3%). There were significant correlations between all vascular parameters; although these were predominantly explained by age. cIMT was independently associated with classical risks and also PWV (adjusted standardized β = 0.31, P = 0.001). However, traditional risks showed almost no independent associations with other vascular measurements. In contrast, serum phosphate and 1,25-dihydroxyvitamin D (1,25-OHD) correlated with PWV and the presence of VC, respectively. After adjustment, every 1 pg/mL increase in 1,25-OHD was related to a 3% reduction in the chance of VC (odds ratio 0.97; 95% confidence interval 0.94-1.00, P = 0.03). Medication use, HOMA-IR and C-reactive protein did not correlate with any of the vascular measures. CONCLUSIONS This study demonstrates extensive vascular disease across multimodality imaging in moderate CKD. Atherosclerotic burden correlated with traditional risks and PWV, while higher 1,25-OHD was associated with less VC. The lack of association between renal function and imaging indices raises the possibility of a threshold, rather than graded uraemic effect on vascular health that warrants further exploration.