Miracle-dz/UniFAR-FTUs huggingface dataset:
Bayesian Optimal Control of Smoothly Parameterized Systems: The Lazy Posterior Sampling Algorithm

We study Bayesian optimal control of a general class of smoothly parameterized Markov decision problems. Since computing the optimal control is computationally expensive, we design an algorithm that trades off performance for computational efficiency. The algorithm is a lazy posterior sampling method that maintains a distribution over the unknown parameter. The algorithm changes its policy only when the variance of the distribution is reduced sufficiently. Importantly, we analyze the algorithm and show the precise nature of the performance vs. computation tradeoff. Finally, we show the effectiveness of the method on a web server control application.
Triterpenoid Contents and Anti-Inﬂammatory Properties of the Methanol Extracts of Ligustrum Species Leaves

Ligustrum (privet) plants are used by Chinese physicians to prevent and cure hepatitis and chronic bronchitis. Three common Ligustrum plant spp. , namely Ligustrum lucidum Ait. (LL), L. pricei Hayata (LP) and L. sinensis Lour. (LS) were collected to assess their analgesic/anti-inflammatory properties on chemical-induced nociception and carrageenan-induced inflammation in rodents. The methanol extracts from Ligustrum plants leaves effectively inhibited nociceptive responses induced by 1% acetic acid and 1% formalin. LP and LL reduced the edema induced by 1% carrageenan. LP exhibited the best potency of the Ligustrum plants. Furthermore, LP reduced the abdominal Evan’s blue extravasations caused by lipopolysaccharide, lipoteichoic acid, autocrines and sodium nitroprusside. The triterpenoid content of the three Ligustrum spp. was measured by high performance liquid chromatography using a photodiode array detector. LP contained the highest content of amyrin, betulinic acid and lupeol. LL had the highest content of oleanolic acid and ursolic acid. The various degrees of analgesic/anti-inflammatory effects among three Ligustrum plants may be related to their different triterpenoid contents. LP is a potential analgesic and anti-inflammatory Ligustrum plant. The effects of LP are partially related to the inhibition of cyclooxygenase-2 activity and a decrease in microvascular permeability via the actions of autocrines and kinins.
PROBLEMATIC INTERNET USE

This publication is intended for professionals training or practicing in mental health and not for the general public. The opinions expressed are those of the authors and do not necessarily represent the views of the Editor or IACAPAP. This publication seeks to describe the best treatments and practices based on the scientific evidence available at the time of writing as evaluated by the authors and may change as a result of new research. Readers need to apply this knowledge to patients in accordance with the guidelines and laws of their country of practice. Some medications may not be available in some countries and readers should consult the specific drug information since not all dosages and unwanted effects are mentioned. Organizations, publications and websites are cited or linked to illustrate issues or as a source of further information. This does not mean that authors, the Editor or IACAPAP endorse their content or recommendations, which should be critically assessed by the reader. Websites may also change or cease to exist. ©IACAPAP 2012. This is an open-access publication under the Creative Commons Attribution Non-commercial License. Use, distribution and reproduction in any medium are allowed without prior permission provided the original work is properly cited and the use is non-commercial. Send comments about this e-book or chapter to jmreyATbigpond.net. au
Distribution, physiology and pharmacology of relaxin‐3/RXFP3 systems in brain

Relaxin‐3 is a member of a superfamily of structurally‐related peptides that includes relaxin and insulin‐like peptide hormones. Soon after the discovery of the relaxin‐3 gene, relaxin‐3 was identified as an abundant neuropeptide in brain with a distinctive topographical distribution within a small number of GABAergic neuron populations that is well conserved across species. Relaxin‐3 is thought to exert its biological actions through a single class‐A GPCR – relaxin‐family peptide receptor 3 (RXFP3). Class‐A comprises GPCRs for relaxin‐3 and insulin‐like peptide‐5 and other peptides such as orexin and the monoamine transmitters. The RXFP3 receptor is selectively activated by relaxin‐3, whereas insulin‐like peptide‐5 is the cognate ligand for the related RXFP4 receptor. Anatomical and pharmacological evidence obtained over the last decade supports a function of relaxin‐3/RXFP3 systems in modulating responses to stress, anxiety‐related and motivated behaviours, circadian rhythms, and learning and memory. Electrophysiological studies have identified the ability of RXFP3 agonists to directly hyperpolarise thalamic neurons in vitro, but there are no reports of direct cell signalling effects in vivo. This article provides an overview of earlier studies and highlights more recent research that implicates relaxin‐3/RXFP3 neural network signalling in the integration of arousal, motivation, emotion and related cognition, and that has begun to identify the associated neural substrates and mechanisms. Future research directions to better elucidate the connectivity and function of different relaxin‐3 neuron populations and their RXFP3‐positive target neurons in major experimental species and humans are also identified.
Do galaxy mergers form elliptical galaxies? A comparison of kinematic and photometric properties

We present near-IR K-band imaging and spectroscopy of a sample of galaxy mergers, which we use to derive light profile indices, absolute magnitudes and central velocity dispersions. It is found that the light distributions of mergers more nearly resemble those of ellipticals than of bulges, but that the mergers lie well away from the Fundamental Plane defined by the ellipticals. This is interpreted as being due to enhancement of the K-band surface brightness of the mergers by a significant population of supergiant stars, and independent evidence for such a population is inferred from measurements of the depth of the 2.3 µm CO absorption feature.
Metabolic Plasticity in Resting and Thrombin Activated Platelets

Platelet thrombus formation includes several integrated processes involving aggregation, secretion of granules, release of arachidonic acid and clot retraction, but it is not clear which metabolic fuels are required to support these events. We hypothesized that there is flexibility in the fuels that can be utilized to serve the energetic and metabolic needs for resting and thrombin-dependent platelet aggregation. Using platelets from healthy human donors, we found that there was a rapid thrombin-dependent increase in oxidative phosphorylation which required both glutamine and fatty acids but not glucose. Inhibition of fatty acid oxidation or glutamine utilization could be compensated for by increased glycolytic flux. No evidence for significant mitochondrial dysfunction was found, and ATP/ADP ratios were maintained following the addition of thrombin, indicating the presence of functional and active mitochondrial oxidative phosphorylation during the early stages of aggregation. Interestingly, inhibition of fatty acid oxidation and glutaminolysis alone or in combination is not sufficient to prevent platelet aggregation, due to compensation from glycolysis, whereas inhibitors of glycolysis inhibited aggregation approximately 50%. The combined effects of inhibitors of glycolysis and oxidative phosphorylation were synergistic in the inhibition of platelet aggregation. In summary, both glycolysis and oxidative phosphorylation contribute to platelet metabolism in the resting and activated state, with fatty acid oxidation and to a smaller extent glutaminolysis contributing to the increased energy demand.
Implementation of a Rapid Genotypic Assay to Promote Targeted Ciprofloxacin Therapy of Neisseria gonorrhoeae in a Large Health System

Multidrug-resistant Neisseria gonorrhoeae is a top threat to public health. In November 2015, UCLA Health introduced a rapid gyrase A (gyrA) genotypic assay for prediction of Neisseria gonorrhoeae susceptibility to ciprofloxacin. We found a significant reduction in ceftriaxone use with a concomitant increase in targeted therapy.
Compliance for single and multiple dose regimens of superactivated charcoal: A prospective study of patients in a clinical trial

Background. Although activated charcoal is widely used for the treatment of self-poisoning, its effectiveness is unknown. An important consideration is patient compliance since poor compliance will limit effectiveness. We aimed to describe compliance in a randomized controlled trial (RCT) performed in Sri Lanka, presuming that this would set the upper limits for compliance in routine clinical use. Method. 1,103 patients randomized to single or multiple (six doses q4h) 50 g doses of superactivated charcoal were prospectively observed. Charcoal was given by study doctors who recorded the amount ingested and the amount of persuasion required for the patients to drink the charcoal. Results. 559 patients were randomized to receive one dose and 544 to receive six doses. Data was available for 1,071 (97%) patients. Eighty-eight were unable to complete their course; 98 required a NG tube, leaving 885 patients that received the first dose by mouth. The mean estimated amount of the prescribed dose of charcoal taken orally as a single or first dose was 83% (95% C.I. 82–84%). For patients receiving multiple doses, this amount fell over the next five doses to 66% (63–69%). While only 3.2% of patients refused the first dose, 12.3% refused the sixth. Relatively less persuasion was required for patients ingesting the first or single dose; 38% of patients required intense persuasion by the sixth dose. Conclusion. Compliance for a single dose of superactivated charcoal among trial patients was good. However, even in the ideal circumstances of a RCT, compliance decreased thereafter for patients taking more than one dose.
Propagation characteristics of horizontally and vertically polarized electric fields in an indoor environment: simple model and results

This paper presents measurement results that demonstrate the different propagation characteristics of the vertical and horizontal polarizations and their crosscorrelation coupling under line-of-sight and non-line-of-sight conditions. We also present a simplified model for the propagation environment that uses an approach similar to the method of images, and achieves results that match the measurements.
Remote ischaemic pre- and delayed postconditioning – similar degree of cardioprotection but distinct mechanisms

Myocardial ischaemia–reperfusion injury can be significantly reduced by an episode(s) of ischaemia–reperfusion applied prior to or during myocardial ischaemia (MI) to peripheral tissue located at a distance from the heart; this phenomenon is called remote ischaemic conditioning (RIc). Here, we compared the efficacy of RIc in protecting the heart when the RIc stimulus is applied prior to, during and at different time points after MI. A rat model of myocardial ischaemia–reperfusion injury involved 30 min of left coronary artery occlusion followed by 120 min of reperfusion. Remote ischaemic conditioning was induced by 15 min occlusion of femoral arteries and conferred a similar degree of cardioprotection when applied 25 min prior to MI, 10 or 25 min after the onset of MI, or starting 10 min after the onset of reperfusion. These RIc stimuli reduced infarct size by 54, 56, 56 and 48% (all P < 0.001), respectively. Remote ischaemic conditioning applied 30 min into the reperfusion period was ineffective. Activation of sensory nerves by application of capsaicin was effective in establishing cardioprotection only when elicited prior to MI. Vagotomy or denervation of the peripheral ischaemic tissue both completely abolished cardioprotection induced by RIc applied prior to MI. Cardioprotection conferred by delayed remote postconditioning was not affected by either vagotomy or peripheral denervation. These results indicate that RIc confers potent cardioprotection even if applied with a significant delay after the onset of myocardial reperfusion. Cardioprotection by remote preconditioning is critically dependent on afferent innervation of the remote organ and intact parasympathetic activity, while delayed remote postconditioning appears to rely on a different signalling pathway(s).
Rare Variants in Genes Encoding MuRF1 and MuRF2 Are Modifiers of Hypertrophic Cardiomyopathy

Modifier genes contribute to the diverse clinical manifestations of hypertrophic cardiomyopathy (HCM), but are still largely unknown. Muscle ring finger (MuRF) proteins are a class of muscle-specific ubiquitin E3-ligases that appear to modulate cardiac mass and function by regulating the ubiquitin-proteasome system. In this study we screened all the three members of the MuRF family, MuRF1, MuRF2 and MuRF3, in 594 unrelated HCM patients and 307 healthy controls by targeted resequencing. Identified rare variants were confirmed by capillary Sanger sequencing. The prevalence of rare variants in both MuRF1 and MuRF2 in HCM patients was higher than that in control subjects (MuRF1 13/594 (2.2%) vs. 1/307 (0.3%), p = 0.04; MuRF2 22/594 (3.7%) vs. 2/307 (0.7%); p = 0.007). Patients with rare variants in MuRF1 or MuRF2 were younger (p = 0.04) and had greater maximum left ventricular wall thickness (p = 0.006) than those without such variants. Mutations in genes encoding sarcomere proteins were present in 19 (55.9%) of the 34 HCM patients with rare variants in MuRF1 and MuRF2. These data strongly supported that rare variants in MuRF1 and MuRF2 are associated with higher penetrance and more severe clinical manifestations of HCM. The findings suggest that dysregulation of the ubiquitin-proteasome system contributes to the pathogenesis of HCM.
Light-weight virtual humans

3D whole body, electro-optical scanners have facilitated the creation of personalised, realistic human models. However, realism comes at the cost of a large number of polygons that may surpass the time/accuracy requirement set for rendering/computation in a variety of application systems. We present new automatic constraints that approximate the symmetry of human body parts. These feature constraints help ensure that the overall shape and dimension of body parts are retained even at very low polygon counts. In comparison with established simplification algorithms they reduce the geometric error of the model at the lower level of detail range. The constraints also ensure a mesh structure that improves the rendering quality of the model at low complexity representations.
Is Endotoxemia in Stable Hemodialysis Patients an Artefact? Limitations of the Limulus Amebocyte Lysate Assay and Role of (1→3)-β-D Glucan

Background Elevated blood endotoxin levels are frequently reported in the dialysis population and are strongly linked with inflammation, a major predictor of mortality. Virtually all studies have employed the Limulus Amoebocyte Lysate (LAL) assay to detect endotoxin. However this assay is not endotoxin-specific and can be activated by (1→3)-β-glucan (BG), a component of fungal cell walls leading to false positive signals. Very few studies have taken account of this. We examined the influence of BG-based activation of the LAL assay on the detection of endotoxemia in this setting. Method We measured plasma endotoxin levels in 50 hemodialysis patients with and without the use of BG-blocking buffers. These buffers inhibit BG activation of the LAL assay to ensure that any signal detected is endotoxin-specific. Blood samples were measured for BG, interleukin-6 (IL-6), tumor necrosis factor-alfa (TNF-α) to examine the association between endotoxin signals, BG and inflammation. Results Endotoxin signals were detected in 50% of patients. On repeat measurement with a BG-blocking buffer, all detected endotoxin signals were extinguished. No patient had detectable endotoxemia. Plasma BG levels were significantly elevated in 58% of patients and were higher in those with detectable endotoxin signals using the LAL assay without BG-blocking buffers (78vs.54pg/mL;p<0.001). Endotoxin signal and BG levels did not correlate with levels of TNF-α or IL-6. Conclusion Use of the LAL assay for blood endotoxin detection in dialysis patients has its limitations due to high blood BG. Endotoxemia frequently reported in non-infected hemodialysis patients may be artefactual due to BG interference.
Weak Ties and Self-regulation in Job Search

The purpose of this study is to empirically investigate the relationship between the self-regulatory variable of goal orientation and the extent to which job seekers reach out to and use weak ties in their job search. Weak ties, as defined by Granovettor, are connections to densely knit networks outside the individual’s direct contacts who could provide nonredundant information. The study builds on the previous conceptual work that discussed how learning and performance goal orientation, as a part of a larger system of self-regulatory variables, may affect the extent to which individuals seek feedback and network during job search. Using a sample of Canadian job seekers, this study examines whether learning goal-oriented individuals contact weak ties more often than performance goal-oriented individuals. The results indicate that both performance and learning goal orientation are significant predictors of weak tie counts.
Efficacy of self-control and patience interventions in adolescents

ABSTRACT Self-control and patience are character strengths predictive of positive developmental outcomes, but few interventions targeting their growth have been tested in adolescents. Moreover, interventions based on the limited-strength model of self-control have received considerable criticism, but few studies have tested moderation of interventions by motivational variables fundamental to computational and process models of self-control. To correct this deficiency, we tested the ability of three interventions—using one’s nondominant hand, engaging in cognitive reappraisal exercises, and tracking one’s schedule—to increase self-control and patience in 355 high school students (mean = 16.0 years; 59% female). The nondominant hand and schedule tracking conditions were found to increase self-control, patience, and well-being only when the perceived difficulty was low. Results suggest that the limited-strength model of self-control is insufficient and underscore the explanatory power of computational and process models that account for difficulty. Implications for constructing character interventions for adolescents are discussed.
Understanding Tablet Consumers

This exploratory study surveyed 379 undergraduate students at a southeastern university to investigate the factors that contribute to the consumer ownership of tablets, iPads, and dual adoption of both a tablet and smartphone. It also examines the factors that may predict a consumer’s likelihood to own a tablet in the future, given their current status as a non-owner. The findings consistently demonstrate the importance of perceived tablet usefulness, microblogging social media usage, and computer commerce in affecting tablet, iPad, and dual mobile device ownership.
Reevaluation of Mineral aerosol radiative forcings suggests a better agreement with satellite and AERONET data

Modelling studies and satellite retrievals do not agree on the amplitude and/or sign of the direct radiative per- turbation from dust. Modelling studies have systematically overpredicted mineral dust absorption compared to estimates based upon satellite retrievals. In this paper we first point out the source of this discrepancy, which originates from the shortwave refractive index of dust used in models. The imag- inary part of the refractive index retrieved from AERONET over the range 300 to 700 nm is 3 to 6 times smaller than that used previously to model dust. We attempt to constrain these refractive indices using a mineralogical database and varying the abundances of iron oxides (the main absorber in the visible). We first consider the optically active min- eral constituents of dust and compute the refractive indices from internal and external mixtures of minerals with rela- tive amounts encountered in parent soils. We then compute the radiative perturbation due to mineral aerosols for inter- nally and externally mixed minerals for 3 different hematite contents, 0.9%, 1.5% and 2.7% by volume. These constant amounts of hematite allow bracketing the influence of dust aerosol when it is respectively an inefficient, standard and a very efficient absorber. These values represent low, central and high content of iron oxides in dust determined from the mineralogical database. Linke et al. (2006) determined inde- pendently that iron-oxides represent 1.0 to 2.5% by volume using x-Ray fluorescence on 4 different samples collected over Morocco and Egypt. Based upon values of the refrac- tive index retrieved from AERONET, we show that the best agreement between 440 and 1020 nm occurs for mineral dust internally mixed with 1.5% volume weighted hematite. This representation of mineral dust allows us to compute, using a general circulation model, a new global estimate of min- eral dust perturbation between -0.47 and -0.24 Wm 2 at the top of the atmosphere, and between -0.81 and -1.13 Wm 2 at the surface for both shortwave and longwave wavelengths. The anthropogenic dust fraction is thought to account for be- tween 10 and 50% of the total dust load present in the at- mosphere. We estimate a top of the atmosphere forcing be- tween -0.03 and -0.25 Wm 2 , which is markedly different that the IPCC range of -0.6 to +0.4 Wm 2 (IPCC, 2001). The 24-h average atmospheric heating by mineral dust dur- ing summer over the tropical Atlantic region (15 N-25 N; 45 W-15 W) is in the range +22 to +32 Wm 2 1 which compares well with the 30±4 Wm 2 1 measured by Li et al. (2004) over that same region. The refractive indices from Patterson et al. (1977) and from Volz (1973) overestimate by a factor of 2 the energy absorbed in the column during sum- mer over the same region. This discrepancy is due to too large absorption in the visible but we could not determine if this is linked to the sample studied by Patterson et al. (1997) or to the method used in determining the refractive index.
Further results on interference cancellation and space-time block codes

Space-time block codes (STBC) make use of a rich algebraic structure to provide diversity gains with small decoding complexity. We show that the rich algebraic structure of STBC reduces the hardware and software complexity of interference cancellation (IC) techniques. Additionally, after the IC stage, transmitted symbols can still be recovered with space-time diversity gains. We present three illustrative examples of IC in wireless networks where cochannel users employ STBC. First, we show that any STBC that is based on an orthogonal design allows IC of two cochannel users with simple linear processing. Second, we show that for S.M. Alamouti's STBC (see IEEE Journal on Selected Areas in Communication, vol.16, no.8, p.1451-8, 1998), K>2 users can be detected with simple linear processing, while still ensuring space-time diversity gains. Third, capitalizing on recent work on single-carrier frequency-domain STBC, we study how the aforementioned IC schemes can be modified for frequency-selective channels.