Miracle-dz/UniFAR-FTUs huggingface dataset:
Ownership Structure and the Relationship Between Financial Slack and R&D Investments: Evidence from Korean Firms

We use agency theory to examine the influence of ownership structure on the relationship between financial slack and R&D investments, highlighting how that relationship might differ depending on the identity of the owners, and their potentially different interests. In doing so, we extend the scope of agency theory by examining the principal-principal conflicts of interests that may exist among different types of owners. Using a sample of Korean manufacturing firms in R&D-intensive industries between 1998 and 2003, we find that financial slack has an inverted U-shaped relationship with R&D investments. Furthermore, that relationship varies depending on the presence of different types of owners. Family ownership positively moderates the relationship between financial slack and R&D investments, whereas domestic institutional investors and foreign investors negatively moderate that relationship. Our results show that distinguishing among different types of owners is instrumental in enhancing our understanding of the nature of the relationship between financial slack and R&D investments.
Manufacturing of the EuCARD2 Roebel-Based Cos-Theta Coils at CEA Saclay

In the framework of the FP7 EuCARD2 project, CEA Saclay developed a cos-theta insert magnet, wound with REBCO high temperature superconductor Roebel cable. Each dipole coil consists of a single arched layer of conductors, insulated with a glass fiber sleeve and impregnated with epoxy resin for mechanical reinforcement. Tooling has been developed to carefully guide the Roebel cable during the winding phase, transfer the coil to the impregnation mold and impregnate it. The magnet is made of two coils assembled around a Nitronic 40 hollow core to mechanically limit its ovalization when operating in a 13 T background field. The structure is completed by the addition of an external stainless steel tube surrounding the coils. This paper details manufacturing tools and fabrication processes validated with stainless steel dummy cable and relates about the fabrication of two superconducting coils. The magnet assembly and preparation for the tests in standalone configuration in INFN-LASA test facility are foreseen for the end of this year.
First-principles based quantum transport simulations of nanoscale field effect transistors

We present first-principles density functional theory (DFT) based quantum transport simulations of nanoscale field effect transistors made of Ge, Si, strained-Si, and few-layer black phosphorus channels. The effects of atomistically modeled, crystalline/amorphous SiO2 gate dielectrics on device performance are investigated. A spectral adjustment technique is developed to overcome the band gap underestimation problem of DFT and applied to simulations of tunnel field effect transistors.
MicroRNA Dysregulation in the Spinal Cord following Traumatic Injury

Spinal cord injury (SCI) triggers a multitude of pathophysiological events that are tightly regulated by the expression levels of specific genes. Recent studies suggest that changes in gene expression following neural injury can result from the dysregulation of microRNAs, short non-coding RNA molecules that repress the translation of target mRNA. To understand the mechanisms underlying gene alterations following SCI, we analyzed the microRNA expression patterns at different time points following rat spinal cord injury. The microarray data reveal the induction of a specific microRNA expression pattern following moderate contusive SCI that is characterized by a marked increase in the number of down-regulated microRNAs, especially at 7 days after injury. MicroRNA downregulation is paralleled by mRNA upregulation, strongly suggesting that microRNAs regulate transcriptional changes following injury. Bioinformatic analyses indicate that changes in microRNA expression affect key processes in SCI physiopathology, including inflammation and apoptosis. MicroRNA expression changes appear to be influenced by an invasion of immune cells at the injury area and, more importantly, by changes in microRNA expression specific to spinal cord cells. Comparisons with previous data suggest that although microRNA expression patterns in the spinal cord are broadly similar among vertebrates, the results of studies assessing SCI are much less congruent and may depend on injury severity. The results of the present study demonstrate that moderate spinal cord injury induces an extended microRNA downregulation paralleled by an increase in mRNA expression that affects key processes in the pathophysiology of this injury.
Ligustrum robustum Intake, Weight Loss, and Gut Microbiota: An Intervention Trial

Ligustrum robustum (LR) shows antiobesity effects in animal studies. However, little is known about the effect on human. The present study aimed to investigate the effect of LR intake on weight change in obese women and the role of gut microbiota. Thirty overweight and obese female participants (BMI ≥24 kg/m2) were recruited in the current study. The participants drank LR 10g/d for 12 wks. Their body composition and related biomarkers were assessed. Alterations of the gut microbiota were analyzed using 16S rRNA sequencing. The primary outcome was the change in body weight. LR intake resulted in 2.5% weight loss over 12 wks (P<0.01). Change in body fat at 12 wk was -1.77 ± 1.19 kg (P<0.01). In addition, decreased Firmicutes-to-Bacteroidetes ratio (P=0.03), increased richness (the ACE estimator, P<0.01; the Chao1 estimator, P<0.01), and altered representative taxa of the gut microbiota were observed. Bacteroidaceae, Bacteroides, Bacilli, and Lactobacillales were higher while Ruminococcaceae, Enterobacteriaceae, Enterobacteriales, Lachnospiraceae, Clostridia, and Clostridiales were lower at 12 wk. Moreover, LR intervention decreased fasting glucose (P<0.01), serum leptin (P<0.01), and IL8 (P=0.02) and increased HOMA-β (P<0.01). LR intervention moderately decreased the body weight in overweight and obese women and such effect might be due to modulation of gut microbiota.
Clinical Research on Integrative Treatment of Colon Carcinoma with Oncothermia and Clifford TCM Immune Booster

Nowadays oncology faces the challenge of non-toxic integrative therapies for cancer treatment. Clifford Hospital is devoted to this research and offers a full range of therapies, representing a synergy between the Traditional Chinese Medicine (TCM) and the state-of-art facilities of the Modern Western Medicine (MWM). Our present article reports research of the therapeutic efficacy and adverse reactions of integrative treatment of colon carcinoma with Oncothermia (OT) and Clifford TCM Immune Booster (CIB). The clinical study involved 157 patients in three-arms of treatments: CIB alone, OT alone and OT+ CIB combined. Results definitely prefer the combination therapy, which shows synergy of OT with CIB.
Structured model reduction of power systems

This paper shows how structured model order reduction can be applied to power systems. For power systems divided into a study area and an external area, the proposed algorithm can be used to reduce the external area to a low order linear system, while retaining the nonlinear description of the study system. The reduction of the external area is done in such a way that the study system is affected as little as possible. It is shown that a lower model order can be attained when information about the study system is taken into consideration, than if the external system is reduced independently of it.
A Device for Long-Term Perfusion, Imaging, and Electrical Interfacing of Brain Tissue In vitro

Distributed microelectrode array (MEA) recordings from consistent, viable, ≥500 μm thick tissue preparations over time periods from days to weeks may aid in studying a wide range of problems in neurobiology that require in vivo-like organotypic morphology. Existing tools for electrically interfacing with organotypic slices do not address necrosis that inevitably occurs within thick slices with limited diffusion of nutrients and gas, and limited removal of waste. We developed an integrated device that enables long-term maintenance of thick, functionally active, brain tissue models using interstitial perfusion and distributed recordings from thick sections of explanted tissue on a perforated multi-electrode array. This novel device allows for automated culturing, in situ imaging, and extracellular multi-electrode interfacing with brain slices, 3-D cell cultures, and potentially other tissue culture models. The device is economical, easy to assemble, and integrable with standard electrophysiology tools. We found that convective perfusion through the culture thickness provided a functional benefit to the preparations as firing rates were generally higher in perfused cultures compared to their respective unperfused controls. This work is a step toward the development of integrated tools for days-long experiments with more consistent, healthier, thicker, and functionally more active tissue cultures with built-in distributed electrophysiological recording and stimulation functionality. The results may be useful for the study of normal processes, pathological conditions, and drug screening strategies currently hindered by the limitations of acute (a few hours long) brain slice preparations.
Modification of PCC with agar and its application in papermaking

Modification of filler with polysaccharides such as starch, cellulose and their derivatives by preflocculation is an effective means to overcome the main drawback of mechanical strength decline resulting from filler addition. Agar is a mucilaginous polysaccharide extracted from red algaes and was used to modify precipitated calcium carbonate (PCC) for papermaking in our studies. Results showed that when 0.03% cationic polyacrylamide (CPAM) was used as retention aid, tensile index of handsheets using agar (3%, based on PCC) modified PCC as filler was 29.5% higher than native PCC, whereas filler retention did not change obviously. Optical microscope observation and laser diffraction particle size analysis confirmed that PCC was flocculated and coated by agar after modification. Characterizations of mechanical strength and filler retention of handsheets at different filler content indicated the handsheets can be filled with about 10% more agar modified PCC but to maintain the same strength level.
Identification of collapsin response mediator protein‐2 as a potential marker of colorectal carcinoma by comparative analysis of cancer cell secretomes

The cancer cell secretome may contain many potentially useful biomarkers. We therefore sought to identify proteins in the conditioned media of colorectal carcinoma (CRC) cell lines but not in those from other cancer cell lines. The secretomes of 21 cancer cell lines derived from 12 cancer types were analyzed by SDS‐PAGE combined with MALDI‐TOF MS. Among the 325 proteins identified, collapsin response mediator protein‐2 (CRMP‐2) was chosen for evaluation as a potential CRC biomarker, since it was selectively detected in the CRC cell line secretome and has never been reported as a cancer biomarker. Immunohistochemical analysis of 169 CRC specimens showed that CRMP‐2 was positively detected in 58.6% of the tumors, but weakly or not detected in >90% of the adjacent nontumor epithelial cells. Moreover, the CRMP‐2‐positive rate was significantly increased in earlier stage tumors and lymph node metastasis. Plasma CRMP‐2 levels were significantly higher in CRC patients (N = 201) versus healthy controls (N = 201) (61.3 ± 34.6 vs. 40.2 ± 24.3 ng/mL, p = 0.001). Our results indicate that comparative analysis of cancer cell secretome is a feasible strategy for identifying potential cancer biomarkers, and that CRMP‐2 may be a novel CRC biomarker.
SmoothGrad: removing noise by adding noise

Explaining the output of a deep network remains a challenge. In the case of an image classifier, one type of explanation is to identify pixels that strongly influence the final decision. A starting point for this strategy is the gradient of the class score function with respect to the input image. This gradient can be interpreted as a sensitivity map, and there are several techniques that elaborate on this basic idea. This paper makes two contributions: it introduces SmoothGrad, a simple method that can help visually sharpen gradient-based sensitivity maps, and it discusses lessons in the visualization of these maps. We publish the code for our experiments and a website with our results.
Genome-wide gene order distances support clustering the gram-positive bacteria

Initially using 143 genomes, we developed a method for calculating the pair-wise distance between prokaryotic genomes using a Monte Carlo method to estimate the conservation of gene order. The method was based on repeatedly selecting five or six non-adjacent random orthologs from each of two genomes and determining if the chosen orthologs were in the same order. The raw distances were then corrected for gene order convergence using an adaptation of the Jukes-Cantor model, as well as using the common distance correction D′ = −ln(1-D). First, we compared the distances found via the order of six orthologs to distances found based on ortholog gene content and small subunit rRNA sequences. The Jukes-Cantor gene order distances are reasonably well correlated with the divergence of rRNA (R2 = 0.24), especially at rRNA Jukes-Cantor distances of less than 0.2 (R2 = 0.52). Gene content is only weakly correlated with rRNA divergence (R2 = 0.04) over all distances, however, it is especially strongly correlated at rRNA Jukes-Cantor distances of less than 0.1 (R2 = 0.67). This initial work suggests that gene order may be useful in conjunction with other methods to help understand the relatedness of genomes. Using the gene order distances in 143 genomes, the relations of prokaryotes were studied using neighbor joining and agreement subtrees. We then repeated our study of the relations of prokaryotes using gene order in 172 complete genomes better representing a wider-diversity of prokaryotes. Consistently, our trees show the Actinobacteria as a sister group to the bulk of the Firmicutes. In fact, the robustness of gene order support was found to be considerably greater for uniting these two phyla than for uniting any of the proteobacterial classes together. The results are supportive of the idea that Actinobacteria and Firmicutes are closely related, which in turn implies a single origin for the gram-positive cell.
Clustering and differential evolution for multimodal optimization

This paper presents a new differential evolution algorithm for multimodal optimization that uses self-adaptive parameter control, clustering and crowding methods. The algorithm includes a new clustering mechanism that is based on small subpopulations with the best strategy and, as such, improves the algorithm's efficiency. Each subpopulation is generated according to the best individual from a population that is not added to any other subpopulation. These small subpopulations are also used to determine population size and to replace ‘bad’ individuals. Because of the small subpopulation size and crowding mechanism, bad individuals prevent the best individuals from converging to the optimum. Therefore, the algorithm is trying to replace bad individuals with the individuals that are close to the best individuals. The population size expansion is used within the algorithm according to the number of generated subpopulations and located optima. The proposed algorithm was tested on benchmark functions for CEC'2013 special session and competition on niching methods for multimodal function optimization. The performance of the proposed algorithm was comparable with the state-of-the-art algorithms.
New Hierarchical Phosphorylation Pathway of the Translational Repressor eIF4E-binding Protein 1 (4E-BP1) in Ischemia-Reperfusion Stress*

Eukaryotic initiation factor (eIF) 4E-binding protein 1 (4E-BP1) is a translational repressor that is characterized by its capacity to bind specifically to eIF4E and inhibit its interaction with eIF4G. Phosphorylation of 4E-BP1 regulates eIF4E availability, and therefore, cap-dependent translation, in cell stress. This study reports a physiological study of 4E-BP1 regulation by phosphorylation using control conditions and a stress-induced translational repression condition, ischemia-reperfusion (IR) stress, in brain tissue. In control conditions, 4E-BP1 was found in four phosphorylation states that were detected by two-dimensional gel electrophoresis and Western blotting, which corresponded to Thr69-phosphorylated alone, Thr69- and Thr36/Thr45-phosphorylated, all these plus Ser64 phosphorylation, and dephosphorylation of the sites analyzed. In control or IR conditions, no Thr36/Thr45 phosphorylation alone was detected without Thr69 phosphorylation, and neither was Ser64 phosphorylation without Thr36/Thr45/Thr69 phosphorylation detected. Ischemic stress induced 4E-BP1 dephosphorylation at Thr69, Thr36/Thr45, and Ser64 residues, with 4E-BP1 remaining phosphorylated at Thr69 alone or dephosphorylated. In the subsequent reperfusion, 4E-BP1 phosphorylation was induced at Thr36/Thr45 and Ser64, in addition to Thr69. Changes in 4E-BP1 phosphorylation after IR were according to those found for Akt and mammalian target of rapamycin (mTOR) kinases. These results demonstrate a new hierarchical phosphorylation for 4E-BP1 regulation in which Thr69 is phosphorylated first followed by Thr36/Thr45 phosphorylation, and Ser64 is phosphorylated last. Thr69 phosphorylation alone allows binding to eIF4E, and subsequent Thr36/Thr45 phosphorylation was sufficient to dissociate 4E-BP1 from eIF4E, which led to eIF4E-4G interaction. These data help to elucidate the physiological role of 4E-BP1 phosphorylation in controlling protein synthesis.
Impact of short-term protein supplementation on estrus, ovarian activity, and blood metabolites in Ossimi ewes synchronized with PGF2 α analogue (Cloprostenol) in subtropics

ABSTRACT The aim was to elucidate the effects of short-term, high protein diet on ovarian activity and metabolic status in synchronized Ossimi ewes. Fourteen Ossimi ewes divided into a high protein (HPG; n = 7) and a control group (CG; n = 7). Estrous synchronized using two doses of Prostaglandin F2α (PGF2α) that were administered 10 days apart. For the five days before the second dose of PGF2-α, a high protein diet consisting of 20% crude protein was fed to the HPG and the CG was provided a maintenance diet. The estrus period was significantly longer and the ovulation rate was significantly higher in the HPG as compared to the CG (P < 0.05). A significantly longer ovulation time and larger diameter ovulatory follicles were observed in the HPG (P < 0.05). A high protein diet had a significant effect on the number of recruited follicles and the diameter of the ovulatory follicle (P < 0.05). Significantly higher levels of estradiaol-17β, total protein, albumin, total cholesterol, blood urea, and glucose detected in the HPG as compared to CG ewes (P < 0.05). It is concluded that short-term, high protein flushing may improve estrus expression, ovarian activity, and metabolic status in PGF2α analog synchronized Ossimi ewes.
Infrared Thermography in Dogs with Mammary Tumors and Healthy Dogs

Background Infrared thermography is a painless, noninvasive, nonionizing diagnostic imaging exam used in human medicine as an auxiliary tool for breast cancer diagnosis in women. Hypothesis/Objectives Define thermographic mean temperatures of healthy mammary glands and compare these temperatures with those of mammary glands with tumors in dogs. Animals Fifty client‐owned female dogs were evaluated, including 20 with histopathologically confirmed mammary tumor and 30 clinically healthy (control). Methods A randomized study using infrared thermography analyzed each mammary gland of the animals from the control group and mammary glands with tumors from the tumor group, then the thermographic temperatures obtained were compared. Thermographic exam was performed in a temperature‐controlled room with a cooled thermographic camera—Flir E‐40 (Flir Systems®) Results There was significantly a higher temperature in the caudal abdominal and inguinal mammary glands than the other glands in the healthy group (P < .05). Dogs with mammary tumors had significantly higher thermographic temperature compared with unaffected glands regardless of the tumor size and the location (P < .05). Conclusions and clinical importance The technique seems to be able to assess for the presence of neoplasia within the mammary tissue in bitches. Further investigation is necessary to determine the impact of this technique when adopted clinically.
Non-invasive Stimulation of the Cerebellum in Health and Disease

The cerebellum is linked to motor, cognitive and affective functions. Anatomically, the cerebellum is part of an interconnected network including a wide range of other brain structures. This chapter reviews ways in which non-invasive stimulation has been used to activate or inhibit these circuits and how this has contributed to our understanding of cerebellar function in both motor and non-motor domains. The utility of non-invasive stimulation of the cerebellum in the treatment of neurological and psychiatric diseases (Parkinson’s disease, cerebellar ataxia, stroke, depression and schizophrenia) is discussed. The chapter concludes with consideration of the challenges that must be overcome if noninvasive cerebellar stimulation is to be adopted in a wider clinical setting.
Quantification of Chronic Functional Mitral Regurgitation by Automated 3-Dimensional Peak and Integrated Proximal Isovelocity Surface Area and Stroke Volume Techniques Using Real-Time 3-Dimensional Volume Color Doppler Echocardiography: In Vitro and Clinical Validation

Background—The aim of this study was to test the accuracy of an automated 3-dimensional (3D) proximal isovelocity surface area (PISA) (in vitro and patients) and stroke volume technique (patients) to assess mitral regurgitation (MR) severity using real-time volume color flow Doppler transthoracic echocardiography. Methods and Results—Using an in vitro model of MR, the effective regurgitant orifice area and regurgitant volume (RVol) were measured by the PISA technique using 2-dimensional (2D) and 3D (automated true 3D PISA) transthoracic echocardiography. The mean anatomic regurgitant orifice area (0.35±0.10 cm2) was underestimated to a greater degree by the 2D (0.12±0.05 cm2) than the 3D method (0.25±0.10 cm2; P<0.001 for both). Compared with the flowmeter (40±14 mL), the RVol by 2D PISA (20±19 mL) was underestimated (P<0.001), but the 3D peak (43±16 mL) and integrated PISA-based (38±14 mL) RVol were comparable (P>0.05 for both). In patients (n=30, functional MR), 3D effective regurgitant orifice area correlated well with cardiac magnetic resonance imaging RVol r=0.84 and regurgitant fraction r=0.80. Compared with cardiac magnetic resonance imaging RVol (33±22 mL), the integrated PISA RVol (34±26 mL; P=0.42) was not significantly different; however, the peak PISA RVol was higher (48±27 mL; P<0.001). In addition, RVol calculated as the difference in automated mitral and aortic stroke volumes by real-time 3D volume color flow Doppler echocardiography was not significantly different from cardiac magnetic resonance imaging (34±21 versus 33±22 mL; P=0.33). Conclusions—Automated real-time 3D volume color flow Doppler based 3D PISA is more accurate than the 2D PISA method to quantify MR. In patients with functional MR, the 3D RVol by integrated PISA is more accurate than a peak PISA technique. Automated 3D stroke volume measurement can also be used as an adjunctive method to quantify MR severity.