Miracle-dz/UniFAR-FTUs huggingface dataset:
Neonatal Kyphectomy in the Patient With Myelomeningocele

Study Design. A retrospective cohort study was used to investigate a group of neonates with myelomeningocele who had a kyphectomy performed in conjunction with dural sac closure during the first few days of life. Objectives. To assess the effectiveness of operative intervention in the neonatal period to correct the kyphotic deformity in the patient with myelomeningocele and to monitor its long-term results. Summary of Background Data. Orthopedic management originally focused on the immediate treatment of the kyphotic deformity in the infant with myelomeningocele. However, there has been a movement toward postponing surgical treatment of the kyphos until a later age. This study included the longest follow-up of the largest group of neonates that a single surgeon has managed surgically since the treatment of this condition was originally described. Methods. The radiographic and clinical results for all neonates treated with a kyphectomy at the time of myelomeningocele closure between 1980 and 2000 were analyzed. Results. Neonatal kyphectomy was performed on nine males and two females. The average preoperative kyphotic angle measured 67°. The average initial correction was 77°, and the average loss of correction at follow-up assessment was 55°. There were no serious complications, and wound closure was successful in all patients. One patient required a repeat kyphectomy and posterior spinal fusion at the age of 9 years and 2 months. The average follow-up period was 7 years and 4 months (range 44–174 months). Conclusions. Kyphectomy performed at the time of dural sac closure in the neonate is a safe procedure with excellent initial correction. Eventual recurrence is expected despite the procedure. However, it occurs in the form of a longer, more rounded deformity that is less technically demanding.
Associations between Mindfulness and Implicit Cognition and Self-Reported Affect

Theory suggests that mindful individuals exhibit enhanced attentional processing (e.g., attentional control) and that they maintain a detached perspective to problematic stimuli. For smokers, smoking and affective stimuli are problematic stimuli when they try to quit. In this cross-sectional study, smokers (n = 158) completed 3 modified Stroop tasks (to assess attentional control), 3 Implicit Association Tests (IATs; to assess detached perspective), and a battery of self-report assessments. Degree of mindfulness was negatively associated (P < .05) with self-reported negative affect, perceived stress, and depressive symptom severity, and positively associated (P < .05) with positive affect. Degree of mindfulness was not associated with the ability to disengage attention from smoking or affective stimuli. On the depression IAT, more mindful participants exhibited a more negative IAT effect, suggesting that they may have developed a detached perspective to depression-related stimuli. Theoretical and clinical implications of the data are discussed.
Chikungunya Virus and Central Nervous System Infections in Children, India

Chikungunya virus (CHIKV) is a mosquito-borne alphavirus best known for causing fever, rash, arthralgia, and occasional neurologic disease. By using real-time reverse transcription–PCR, we detected CHIKV in plasma samples of 8 (14%) of 58 children with suspected central nervous system infection in Bellary, India. CHIKV was also detected in the cerebrospinal fluid of 3 children.
Dynamic Derivations for Sequent-Based Logical Argumentation

We introduce a general approach for representing and reasoning with argumentation-based systems. In our framework arguments are represented by Gentzen-style sequents, attacks (conflicts) between arguments are represented by sequent elimination rules, and deductions are made by dynamic proof systems. This framework accommodates different languages and logics in which arguments may be represented, supports a variety of attack relations, and tolerates dynamic changes in the argumentation setting by revising derivations of assertions in light of new information.
ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI MINAT PEMANFAATAN SISTEM INFORMASI DAN PENGGUNAAN SISTEM INFORMASI (STUDI EMPIRIS PADA BMT DI KARISIDENAN PATI)

Tujuan penelitian ini adalah untuk menguji faktor-faktor yang mempengaruhi minat pemanfaatan sistem informasi dan pengaruhnya terhadap penggunaan sistem informasi dengan menguji model yang diajukan oleh Handayani (2007). Data diperoleh dari persepsi individu pemakai sistem informasi pada BMT di Karisidenan Pati. Sebanyak 89 kuesioner kembali dari 100 yang dikirim dan 78 kuesioner yang dapat diolah. Metode pengumpulan data yang digunakan adalah survey menggunakan kuesioner. Analisa data dilakukan dengan menggunakan teknik regresi berganda dan MRA dengan software SPSS 17.Hasil penelitian ini menunjukkan bahwa ekspektasi kinerja,ekspektasi usaha,faktor sosial berpengaruh positif signifikan terhadap minat pemanfaatan sistem informasi. Kondisi yang memfasilitasi dan minat pemanfaatan SI berpengaruh positif terhadap penggunaan SI. Umur dan pengalaman tidak berpengaruh signifikan sebagai variabel moderating. Kata kunci: UTAUT, ekspektasi kinerja, ekspektasi usaha, faktor sosial,kondisi yang memfasilitasi, umur, pengalaman.
Truss Decomposition in Massive Networks

The k-truss is a type of cohesive subgraphs proposed recently for the study of networks. While the problem of computing most cohesive subgraphs is NP-hard, there exists a polynomial time algorithm for computing k-truss. Compared with k-core which is also efficient to compute, k-truss represents the "core" of a k-core that keeps the key information of, while filtering out less important information from, the k-core. However, existing algorithms for computing k-truss are inefficient for handling today's massive networks. We first improve the existing in-memory algorithm for computing k-truss in networks of moderate size. Then, we propose two I/O-efficient algorithms to handle massive networks that cannot fit in main memory. Our experiments on real datasets verify the efficiency of our algorithms and the value of k-truss.
c-Abl Modulates Tumor Cell Sensitivity to Antibody-Dependent Cellular Cytotoxicity

Murray and colleagues used RNAi functional genomics screening of 60 genes from an EGFR gene network and identified that inhibition of c-Abl activity in anti-EGFR-targeted cells can enhance the therapeutic efficacy of cetuximab, an ADCC-promoting anti-EGFR antibody, in colorectal and head and neck cancers. Monoclonal antibodies (mAb) can modulate cancer cell signal transduction and recruit antitumor immune effector mechanisms—including antibody-dependent cellular cytotoxicity (ADCC). Although several clinically effective antibodies can promote ADCC, therapeutic resistance is common. We hypothesized that oncogenic signaling networks within tumor cells affect their sensitivity to ADCC. We developed a screening platform and targeted 60 genes derived from an EGFR gene network using RNAi in an in vitro ADCC model system. Knockdown of GRB7, PRKCE, and ABL1 enhanced ADCC by primary and secondary screens. ABL1 knockdown also reduced cell proliferation, independent of its ADCC enhancement effects. c-Abl overexpression decreased ADCC sensitivity and rescued the effects of ABL1 knockdown. Imatinib inhibition of c-Abl kinase activity also enhanced ADCC—phenocopying ABL1 knockdown—against several EGFR-expressing head-and-neck squamous cell carcinoma cell lines by ex vivo primary natural killer cells. Our findings suggest that combining c-Abl inhibition with ADCC-promoting antibodies, such as cetuximab, could translate into increased therapeutic efficacy of mAbs. Cancer Immunol Res; 2(12); 1186–98. ©2014 AACR.
Autoimmune hepatitis/primary biliary cirrhosis overlap syndrome developed in a patient with vitiligo and Hashimoto thyroiditis.

References 1 Arai M, Yokosuka O, Fujiwara K, Kojima H, Kanda T, Hirasawa H, Saisho H. Fulminant hepatic failure associated with benzbromarone treatment: a case report. J Gastroenterol Hepatol 2002; 17:625–626. 2 Gehenot M, Horsmans Y, Rahier J, Geubel AP. Subfulminant hepatitis requiring liver transplantation after benzarone administration. J Hepatol 1994; 20:842. 3 Hautekeete ML, Henrion J, Naegels S, DeNeve A, Adler M, Deprez C, et al. Severe hepatotoxicity related to benzarone: a report of three cases with two fatalities. Liver 1995; 15:25–29. 4 Russmann S, Lauterburg B. Life-threatening adverse effects of pharmacologic antihyperuricemic therapy. Ther Umsch 2004; 61:575–577. 5 Van der Klauw MM, Houtman PM, Stricker BH, Spoelstra P. Hepatic injury caused by benzbromarone. J Hepatol 1994; 20:376–379. 6 Wagayama H, Shiraki K, Sugimoto K, Fujikawa K, Shimizu A, Takase K, et al. Fatal fulminant hepatic failure associated with benzbromarone. J Hepatol 2000; 32:874. 7 Aithal GP, Watkins PB, Andrade RJ, Larrey D, Molokhia M, Takikawa H, et al. Case definition and phenotype standardization in drug-induced liver injury. Clin Pharmacol Ther 2011; 89:806–815. 8 AMK: Acifugan recall. Pharm Ztg. 2003: 15http://www.pharmazeutischezeitung. de/index.php? id = 28679 [Accessed on 8 October 2012]. 9 Lee MH, Graham GG, Williams KM, Day RO. A benefit-risk assessment of benzbromarone in the treatment of gout. Was its withdrawal from the market in the best interest of patients? Drug Saf 2008; 31:643–665. 10 Hill AB. The environment and disease: association or causation? Proc R Soc Med 1965; 58:295–300. 11 Naranjo CA, Busto U, Sellers EM, Sandor P, Ruiz I, Roberts EA, et al. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther 1981; 30:239–245.
Etiology and outcome of cardioembolic stroke in young adults in Greece.

INTRODUCTION Cardioembolism is the most frequent cause of ischemic stroke in Greece. However, data regarding this stroke subtype in young adults from Greece and the East Mediterranean area are scarce. METHODS We aimed to determine the source of embolism and evaluate outcomes in a sample of young Greek patients with ischemic stroke of cardioembolic etiology. A series of 245 Greek patients with ischemic stroke at an age up to 45 years were selected from a consecutive series of 2820 first-ever stroke patients admitted to our departments during the period January 1998 to December 2008. RESULTS Cardioembolism was diagnosed in 45 cases (18.4%). Almost half of the cases (48.9%) were attributed to congenital anomalies of the interatrial septum, including 13 cases of patent foramen ovale (28.9%), 7 cases of atrial septum aneurysm (15.6%), and 1 case with both defects (2.2%). The majority of strokes in our young patient collective were related to medium-risk sources of embolism, while high-risk sources, namely dilated cardiomyopathy, atrial fibrillation and akinetic left ventricular lesions, were found in only 33.3%. The overall probability of 10-year survival was 89.4% (95% confidence interval 79.4-99.4), whereas the probability of a new composite vascular event was 14.3% (95% confidence interval 2.3-26.3) during the same period. The clinical outcome in general was excellent, since the majority of patients (82.2%) showed no significant handicap on follow up. CONCLUSIONS As in other western countries, it would seem that atrioseptal abnormalities played an important role as a cause of cardioembolism in this young Greek population, whereas atrial fibrillation and other major cardioembolic sources seem to be of minor relevance as compared to stroke in elderly patients.
Sitting Behaviors andMental Health amongWorkers and Nonworkers : The Role ofWeight Status

Objective. To explore the associations between sitting time in various domains and mental health for workers and nonworkers and the role of weight status. Design. Cross-sectional analyses were performed for 1064 respondents (47% men, mean age 59 years) from the Doetinchem Cohort Study 2008-2009. Sedentary behavior was measured by self-reported time spent sitting during transport, leisure time, and at work. Mental health was assessed by the Mental Health Inventory (MHI-5). BMI was calculated based on measured body height and weight. Results. Neither sitting time during transport nor at work was associated with mental health. In the working population, sitting during leisure time, and particularly TV viewing, was associated with poorer mental health. BMI was an effect modifier in this association with significant positive associations for healthy-weight non-workers and obese workers. Conclusion. Both BMI and working status were effect modifiers in the relation between TV viewing and mental health. More longitudinal research is needed to confirm the results and to gain insight into the causality and the underlying mechanisms for the complex relationships among sedentary behaviors, BMI, working status, and mental health.
The human body and millimeter-wave wireless communication systems: Interactions and implications

With increasing interest in millimeter-wave wireless communications, investigations on interactions between the human body and millimeter-wave devices are becoming important. This paper gives examples of today's regulatory requirements, and provides an example for a 60 GHz transceiver. Also, the propagation characteristics of millimeter-waves in the presence of the human body are studied, and four models representing different body parts are considered to evaluate thermal effects of millimeter-wave radiation on the body. Simulation results show that about 34% to 42% of the incident power is reflected at the skin surface at 60 GHz. This paper shows that power density is not suitable to determine exposure compliance when millimeter wave devices are used very close to the body. A temperature-based technique for the evaluation of safety compliance is proposed in this paper.
Lack of Self-Administration of Cocaine in Dopamine D1 Receptor Knock-Out Mice

Evidence suggests a critical role for dopamine in the reinforcing effects of cocaine in rats and primates. However, self-administration has been less often studied in the mouse species, and, to date, “knock-out” of individual dopamine-related genes in mice has not been reported to reduce the reinforcing effects of cocaine. We studied the dopamine D1 receptor and cocaine self-administration in mice using a combination of gene-targeted mutation and pharmacological tools. Two cohorts with varied breeding and experimental histories were tested, and, in both cohorts, there was a significant decrease in the number of D1 receptor knock-out mice that met criteria for acquisition of cocaine self-administration (2 of 23) relative to wild-type mice (27 of 32). After extinction of responding with saline self-administration, dose–response studies showed that cocaine reliably and dose dependently maintained responding greater than saline in all wild-type mice but in none of the D1 receptor knock-out mice. The D1-like agonist SKF 82958 (2,3,4,5,-tetrahydro-6-chloro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine hydrobromide) and the D2-like agonist quinelorane both functioned as positive reinforcers in wild-type mice but not in D1 receptor mutant mice, whereas food and intravenous injections of the opioid agonist remifentanil functioned as positive reinforcers in both genotypes. Finally, pretreatment with the D1-like antagonist SCH 23390 [R-(+)-8-chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepine-7-01] produced surmountable antagonism of the reinforcing effects of cocaine in the commonly used strain C57BL/6J. We conclude that D1 receptor knock-out mice do not reliably self-administer cocaine and that the D1 receptor is critical for the reinforcing effects of cocaine and other dopamine agonists, but not food or opioids, in mice.
Left Atrial Appendage Volume Increased in More Than Half of Patients with Cryptogenic Stroke

Background Ischemic strokes without a well-defined etiology are labeled as cryptogenic, and account for 30–40% of strokes in stroke registries. The left atrial appendage (LAA) is the most typical origin for intracardiac thrombus formation when associated with atrial fibrillation. Here, we examined whether increased LAA volume detected with cardiac computed tomography (cCT) constitutes a risk factor in cryptogenic stroke patients. Methods This study included 82 stroke/TIA patients (57 males; mean age, 58 years) with a diagnosis of cryptogenic stroke after extensive radiological and cardiological investigations. Cases were classified using the TOAST criteria modified by European Association of Echocardiography recommendations for defining cardiac sources of embolism. Forty age- and gender-matched control subjects without cardiovascular diseases were selected for pair-wise comparisons (21 males; mean age, 54 years). LAA volume adjusted for body surface area was measured three dimensionally by tracing the LAA borders on electrocardiogram-gated CT slices. Results In control subjects, mean LAA volume was 3.4±1.1 mL/m2. Mean+2SD, which was considered the upper limit for normal LAA volume was 5.6 mL/m2. In paired Student t-test between the patient group and matched controls, LAA volume was 67% larger in cryptogenic stroke/TIA patients (5.7±2.0 mL/m2 vs. 3.4±1.1 mL/m2; P<0.001). Forty-five (55%) patients with cryptogenic stroke/TIA had enlarged LAA. Conclusion LAA is significantly enlarged in more than half of patients with cryptogenic stroke/TIA. LAA thrombosis may contribute to the pathogenesis of stroke in patients considered to have cryptogenic stroke after conventional evaluation.
Food security and sustainable intensification

The coming decades are likely to see increasing pressures on the global food system, both on the demand side from increasing population and per capita consumption, and on the supply side from greater competition for inputs and from climate change. This paper argues that the magnitude of the challenge is such that action is needed throughout the food system, on moderating demand, reducing waste, improving governance and producing more food. It discusses in detail the last component, arguing that more food should be produced using sustainable intensification (SI) strategies, and explores the rationale behind, and meaning of, this term. It also investigates how SI may interact with other food policy agendas, in particular, land use and biodiversity, animal welfare and human nutrition.
Seasonal Variation of Red Blood Cell Variables in Physically Inactive Men: Effects of Strength Training

The purpose of this study was to investigate if strength training affects red blood cell variables in physically inactive men when taking into account seasonal variations. Seventy-four men aged 20-45 were randomly assigned to training (n = 52) and control (n = 22) groups. Training group underwent 20-week progressive strength training. Body composition and maximal voluntary contraction (MVC) during knee extension were measured before and after intervention. Fasting blood samples were analysed for haematocrit (Hct), count of red blood cells (RBC), haemoglobin (Hb), mean cell haemoglobin concentration (MCHC), and mean cell volume (MCV) at baseline, 10-week and 20-week follow-up. MVC and lean body mass increased in the training group. Hct, Hb and MCHC showed seasonal variation in the control group. The training group increased their Hct from 44.7 +/- 2.6 % to 45.4 +/- 2.5 % (p = 0.026) while the control group decreased their Hct from 44.3 +/- 2.2 % to 43.1 +/- 2.6 % (p = 0.037) after 20-week intervention. By contrast to the control group, the training group increased their Hct (p = 0.001), RBC (p = 0.005) and decreased their MCHC (p < 0.001) from 10-week to 20-week follow-up. We concluded that strength training could affect seasonal variation patterns of red cell variables. Unlike "sport anaemia" induced by endurance training, 20-week strength training elevated Hct.
Five-year outcomes of a brief alcohol intervention for adult in-patients with psychiatric disorders.

AIMS To compare 5 year outcomes (general hospital and mental health morbidity and mortality) among general hospital psychiatric in-patients randomized to receive either an alcohol reduction motivational interview (MI) or information pack (IP), and compare these to matched controls. DESIGN We recruited 120 patients aged 18-64 years who scored >/=8 on the Alcohol Use Disorders Identification Test (AUDIT). We selected matched controls from in-patients not recruited but who reached the same AUDIT threshold. At 5 years, follow-up data were collected via a state-wide hospital record system. FINDINGS There were no significant differences between the MI and IP groups in terms of 'survival' to their first alcohol-related, other general hospital or mental health admission over 5 years. Matched controls had significantly more mental health in-patient episodes (F[1,226] 4.4, P < 0.05) and greater length of hospital stay (F[1,226] 4.8, P < 0.05) than the combined MI-IP group. Furthermore, the MI-IP group had longer 'survival' times to both first general hospital (mean 583 versus 392 days) and mental health in-patient (mean 788 versus 580 days) events. Collapsed across groups, dependent and harmful consumers had shorter 'survival' times than hazardous consumers (AUDIT classifications). CONCLUSIONS Alcohol interventions have medium-term health benefits for those with mental health and alcohol use problems. Importantly, there were no differences in outcome between the intervention groups. The low cost of providing an IP makes it attractive as an alcohol intervention. The AUDIT provided an effective means of identifying those who are at risk of subsequent alcohol-related admissions and may benefit from intervention.
INPP 5 E mutations cause primary cilium signaling defects , ciliary instability and ciliopathies in human and mouse

The primary cilium is an antenna-like structure that protrudes from the cell surface of quiescent/differentiated cells and participates in extracellular signal processing1–3. Here, we report that mice deficient for the lipid 5-phosphatase Inpp5e develop a multiorgan disorder associated with structural defects of the primary cilium. In ciliated mouse embryonic fibroblasts, Inpp5e is concentrated in the axoneme of the primary cilium. Inpp5e inactivation did not impair ciliary assembly but altered the stability of pre-established cilia after serum addition. Blocking phosphoinositide 3-kinase (PI3K) activity or ciliary platelet-derived growth factor receptor a (PDGFRa) restored ciliary stability. In human INPP5E, we identified a mutation affecting INPP5E ciliary localization and cilium stability in a family with MORM syndrome, a condition related to Bardet-Biedl syndrome. Together, our results show that INPP5E plays an essential role in the primary cilium by controlling ciliary growth factor and PI3K signaling and stability, and highlight the consequences of INPP5E dysfunction.
Characteristics of the Population of Deaf and Hard of Hearing Students With Emotional Disturbance in Illinois

The study summarizes a database for the years 1994–1999 on deaf and hard of hearing students in Illinois with a diagnosis of emotional disturbance (N = 115). Data are reported on the group's demographic, domestic, etiologic, communication-related, and intervention-related characteristics. These dually diagnosed students differed from Illinois's general population of deaf and hard of hearing students in many ways, including higher incidences of prematurity, prenatal trauma, and perinatal trauma. They were more likely to have had a later onset of hearing loss, to live in single-parent homes, to belong to an ethnic minority, to live in an urban or suburban area, and to qualify for low-income health care. Many had histories of abuse, 50% were regularly medicated, and 15% were assigned to surrogate parents.