Miracle-dz/UniFAR-FTUs huggingface dataset:
Impact of practice, provider and patient characteristics on delivering screening and brief advice for heavy drinking in primary healthcare: Secondary analyses of data from the ODHIN five-country cluster randomized factorial trial

Abstract Background: The implementation of primary healthcare-based screening and advice that is effective in reducing heavy drinking can be enhanced with training. Objectives: Undertaking secondary analysis of the five-country ODHIN study, we test: the extent to which practice, provider and patient characteristics affect the likelihood of patients being screened and advised; the extent to which such characteristics moderate the impact of training in increasing screening and advice; and the extent to which training mitigates any differences due to such characteristics found at baseline. Methods: A cluster randomized factorial trial involving 120 practices, 746 providers and 46 546 screened patients from Catalonia, England, the Netherlands, Poland, and Sweden. Practices were randomized to receive training or not to receive training. The primary outcome measures were the proportion of adult patients screened, and the proportion of screen-positive patients advised. Results: Nurses tended to screen more patients than doctors (OR = 3.1; 95%CI: 1.9, 4.9). Screen-positive patients were more likely to be advised by doctors than by nurses (OR = 2.3; 95%CI: 1.4, 4.1), and more liable to be advised the higher their risk status (OR = 1.9; 95%CI: 1.3, 2.7). Training increased screening and advice giving, with its impact largely unrelated to practice, provider or patient characteristics. Training diminished the differences between doctors and nurses and between patients with low or high-risk status. Conclusions: Training primary healthcare providers diminishes the negative impacts that some practice, provider and patient characteristics have on the likelihood of patients being screened and advised. Trial registration ClinicalTrials.gov. Trial identifier: NCT01501552
Sensitivity analysis of transformerless PV inverter topologies to physical variations of power devices

Transformerless (TL) topologies are employed in 1φ PV inverter topologies due to their small size and low weight. Avoiding the grid side transformer requires the modulation technique and the basis topology to be accordingly changed in order to mitigate dc current components in the grid side and the leakage current to ground. This paper carries out a sensitivity analysis of selected TL topologies. This analysis investigates the impact of parameter variations of the employed semiconductor devices and detects the device which affects the most the overall efficiency. As a result, relevant info for engineers selecting the most suitable power devices for the implementation of a certain TL topology is provided.
Surgical Treatment for Extracapsular Condylar Fractures of the Mandible

Background: Condylar fractures are considered the most controversial mandibular fractures, regarding both the diagnosis and the treatment. With the increase in surgical indications for handling this type of fracture, it is important to discuss about the advantages and disadvantages of the several surgical approaches available. This article describes the surgical details and postoperative results of the mini-retromandibular transparotid approach for treating extracapsular condylar fractures of the mandible. Methods: In a 1-year period, 16 patients affected by extracapsular condylar fractures with surgical indication were treated with the mini-retromandibular transparotid approach. All the surgeries were executed by the same surgeon. Preoperative and postoperative details of each patient were analyzed. Results: In the postoperatory, only 2 patients had purulent drainage in the associated fractures area and only 1 patient had paresis of the buccal branch of the facial nerve. No scar issues concerning the surgical wound were observed and reintervention was not necessary in any of the patients. Conclusion: The mini-retromandibular transparotid approach offers advantages and should be included as an option for the open treatment of extracapsular condylar fractures of the mandible.
Packaging Materials for Flip Chip and WLP: Underfill Design Using FEM for FC-BGA, FC-CSP, and Moving Towards 2.5/3D.

As technology nodes progress to 16/14nm and beyond underfill materials are presented with the significantly challenging task of maintaining bump protection while ensuring low warpage for ultra low-K dielectric (ULK/ELK) integrity. This challenge is further complicated by the trend toward RoHS compliancy (lead-free) and an ever increasing die size (beyond 25x25mm). Through extensive research and testing, several specifically formulated underfill materials were determined acceptable solutions for these complex issues. As technology nodes progress to smaller processes high stress concentrations are seen at the dielectric layer during thermal cycling. This stress is a typical result of a high glass transition temperature (Tg) / high strength material that often leads delamination or a cracking failure mode of the thin dielectric layer. Too low of a Tg presents a high stress concentration on the bumps which once again constitutes failure, this time, however, the crack is typically seen at the bump location. Th.
I did NOT feel like this at all before the accident: do men and women report different health and life consequences of a road traffic injury?

Background Worldwide, injuries represent one of the leading causes of mortality, and nearly one-quarter of all injuries are road traffic related. In many high-income countries, the burden of road traffic injuries (RTIs) has shifted from premature death to injury and disability with long-term consequences; therefore, it is important to assess the full burden of an RTI on individual lives. Objective To describe how men and women with minor and moderate injuries reported the consequences of an RTI on their health and lives. Methods The study was designed as an explorative qualitative study, in which the answers to an open-ended question concerning the life and health consequences following injury were analysed using systematic text condensation. Participants A total of 692 respondents with a minor or a moderate injury were included. Results The respondents reported the consequences of the crash on their health and lives according to four categories: physical consequences, psychological consequences, everyday life consequences and financial consequences. The results show that medically classified minor and moderate injuries have detrimental long-term health and life consequences. Although men and women report some similar consequences, there are substantial differences in their reported psychological and everyday life consequences following an injury. Women report travel anxiety and PTSD-like symptoms, being life altering for them compared with men, for whom these types of reports were missing. Conclusion These differences emphasise the importance of considering gender-specific physical and psychological consequences following an RTI.
Empirical modelling to predict the refractive index of human blood

Optical techniques used for the measurement of the optical properties of blood are of great interest in clinical diagnostics. Blood analysis is a routine procedure used in medical diagnostics to confirm a patient’s condition. Measuring the optical properties of blood is difficult due to the non-homogenous nature of the blood itself. In addition, there is a lot of variation in the refractive indices reported in the literature. These are the reasons that motivated the researchers to develop a mathematical model that can be used to predict the refractive index of human blood as a function of concentration, temperature and wavelength. The experimental measurements were conducted on mimicking phantom hemoglobin samples using the Abbemat Refractometer. The results analysis revealed a linear relationship between the refractive index and concentration as well as temperature, and a non-linear relationship between refractive index and wavelength. These results are in agreement with those found in the literature. In addition, a new formula was developed based on empirical modelling which suggests that temperature and wavelength coefficients be added to the Barer formula. The verification of this correlation confirmed its ability to determine refractive index and/or blood hematocrit values with appropriate clinical accuracy.
Effect of Oral Methylprednisolone on Clinical Outcomes in Patients With IgA Nephropathy: The TESTING Randomized Clinical Trial

Importance Guidelines recommend corticosteroids in patients with IgA nephropathy and persistent proteinuria, but the effects remain uncertain. Objective To evaluate the efficacy and safety of corticosteroids in patients with IgA nephropathy at risk of progression. Design, Setting, and Participants The Therapeutic Evaluation of Steroids in IgA Nephropathy Global (TESTING) study was a multicenter, double-blind, randomized clinical trial designed to recruit 750 participants with IgA nephropathy (proteinuria greater than 1 g/d and estimated glomerular filtration rate [eGFR] of 20 to 120 mL/min/1.73 m2 after at least 3 months of blood pressure control with renin-angiotensin system blockade] and to provide follow-up until 335 primary outcomes occurred. Interventions Patients were randomized 1:1 to oral methylprednisolone (0.6-0.8 mg/kg/d; maximum, 48 mg/d) (n = 136) or matching placebo (n = 126) for 2 months, with subsequent weaning over 4 to 6 months. Main Outcomes and Measures The primary composite outcome was end-stage kidney disease, death due to kidney failure, or a 40% decrease in eGFR. Predefined safety outcomes were serious infection, new diabetes, gastrointestinal hemorrhage, fracture/osteonecrosis, and cardiovascular events. The mean required follow-up was estimated to be 5 years. Results After randomization of 262 participants (mean age, 38.6 [SD, 11.1] years; 96 [37%] women; eGFR, 59.4 mL/min/1.73 m2; urine protein excretion, 2.40 g/d) and 2.1 years’ median follow-up, recruitment was discontinued because of excess serious adverse events. Serious events occurred in 20 participants (14.7%) in the methylprednisolone group vs 4 (3.2%) in the placebo group (P = .001; risk difference, 11.5% [95% CI, 4.8%-18.2%]), mostly due to excess serious infections (11 [8.1%] vs 0; risk difference, 8.1% [95% CI, 3.5%-13.9%]; P < .001), including 2 deaths. The primary renal outcome occurred in 8 participants (5.9%) in the methylprednisolone group vs 20 (15.9%) in the placebo group (hazard ratio, 0.37 [95% CI, 0.17-0.85]; risk difference, 10.0% [95% CI, 2.5%-17.9%]; P = .02). Conclusions and Relevance Among patients with IgA nephropathy and proteinuria of 1 g/d or greater, oral methylprednisolone was associated with an increased risk of serious adverse events, primarily infections. Although the results were consistent with potential renal benefit, definitive conclusions about treatment benefit cannot be made, owing to early termination of the trial. Trial Registration clinicaltrials.gov Identifier: NCT01560052
Wind effects on the migration routes of trans-Saharan soaring raptors: geographical, seasonal, and interspecific variation

Abstract Wind is among the most important environmental factors shaping birds’ migration patterns. Birds must deal with the displacement caused by crosswinds and their behavior can vary according to different factors such as flight mode, migratory season, experience, and distance to goal areas. Here we analyze the relationship between wind and migratory movements of three raptor species which migrate by soaring–gliding flight: Egyptian vulture Neophron percnopterus, booted eagle Aquila pennata, and short-toed snake eagle Circaetus gallicus. We analyzed daily migratory segments (i.e., the path joining consecutive roosting locations) using data recorded by GPS satellite telemetry. Daily movements of Egyptian vultures and booted eagles were significantly affected by tailwinds during both autumn and spring migrations. In contrast, daily movements of short-toed eagles were only significantly affected by tailwinds during autumn migration. The effect of crosswinds was significant in all cases. Interestingly, Egyptian vultures and booted eagles showed latitudinal differences in their behavior: both species compensated more frequently at the onset of autumn migration and, at the end of the season when reaching their wintering areas, the proportion of drift segments was higher. In contrast, there was a higher drift at the onset of spring migration and a higher compensation at the end. Our results highlight the effect of wind patterns on the migratory routes of soaring raptors, with different outcomes in relation to species, season, and latitude, ultimately shaping the loop migration patterns that current tracking techniques are showing to be widespread in many long distance migrants.
Prognostic role of the cumulative toxicity in patients affected by metastatic renal cells carcinoma and treated with first-line tyrosine kinase inhibitors

Tyrosine kinase inhibitor-related toxicities have been reported to be predictive and/or prognostic factors in patients affected by metastatic renal cell carcinoma (mRCC). We aim to investigate the incidence of cumulative toxicity and its prognostic role in mRCC patients treated with sunitinib or pazopanib. mRCC patients treated with sunitinib or pazopanib at the European Institute of Oncology in Milan were reviewed for the incidence of adverse events. Cumulative toxicity was defined as the presence of more than one selected adverse event of any grade. Prognoses were evaluated by the International mRCC Database Consortium criteria. Progression-free survival (PFS) and overall survival (OS) were estimated using the Kaplan–Meier method and Cox analysis. A total of 104 patients were included in the final analysis. Only 18.3% did not experience any of the selected toxicities: 26.9% had one, 35.6% had two and 19.2% all three toxicities. Accordingly, 54.8% of patients experienced cumulative toxicity. In those with or without cumulative toxicity, the median PFS was 27.6 versus 7.2 months and the median OS was 61.2 versus 18.7 months, respectively. When cumulative toxicity was adjusted for International mRCC Database Consortium prognostic groups, it maintained its prognostic role for both PFS (hazard ratio: 0.31, 95% confidence interval, 0.20–0.49; P<0.001) and OS (hazard ratio: 0.27, 95% confidence interval, 0.15–0.48; P<0.001). A major limitation was the retrospective and monocentric nature of the analysis. We reported the prognostic role of cumulative toxicity because of hypertension, hypothyroidism and hand–foot syndrome in patients affected by mRCC and treated with sunitinib or pazopanib.
Experimental Investigation of the Piezoresistive Properties of Cement Composites with Hybrid Carbon Fibers and Nanotubes

Cement-based sensors with hybrid conductive fillers using both carbon fibers (CFs) and multi-walled carbon nanotubes (MWCNTs) were experimentally investigated in this study. The self-sensing capacities of cement-based composites with only CFs or MWCNTs were found based on preliminary tests. The results showed that the percolation thresholds of CFs and MWCNTs were 0.5–1.0 vol.% and 1.0 vol.%, respectively. Based on these results, the feasibility of self-sensing composites with four different amounts of CFs and MWCNTs was considered under cyclic compression loads. When the amount of incorporated CFs increased and the amount of incorporated MWCNTs decreased, the self-sensing capacity of the composites was reduced. It was concluded that cement-based composites containing both 0.1 vol.% CFs and 0.5 vol.% MWCNTs could be an alternative to cement-based composites with 1.0 vol.% MWCNTs in order to achieve equivalent self-sensing performance at half the price. The gauge factor (GF) for that composite was 160.3 with an R-square of 0.9274 in loading stages I and II, which was similar to the GF of 166.6 for the composite with 1.0 vol.% MWCNTs.
The orbital PDF: general inference of the gravitational potential from steady-state tracers

We develop two general methods to infer the gravitational potential of a system using steady-state tracers, i.e. tracers with a time-independent phase-space distribution. Combined with the phase-space continuity equation, the time independence implies a universal orbital probability density function (oPDF) dP(λ|orbit) ∝ dt, where λ is the coordinate of the particle along the orbit. The oPDF is equivalent to Jeans theorem, and is the key physical ingredient behind most dynamical modelling of steady-state tracers. In the case of a spherical potential, we develop a likelihood estimator that fits analytical potentials to the system and a non-parametric method (‘phase-mark’) that reconstructs the potential profile, both assuming only the oPDF. The methods involve no extra assumptions about the tracer distribution function and can be applied to tracers with any arbitrary distribution of orbits, with possible extension to non-spherical potentials. The methods are tested on Monte Carlo samples of steady-state tracers in dark matter haloes to show that they are unbiased as well as efficient. A fully documented c/python code implementing our method is freely available at a GitHub repository linked from http://icc.dur. ac.uk/data/#oPDF.
Analysis of spherical compression performance of warp-knitted spacer fabrics

Warp-knitted spacer fabrics for cushion products are in contact with different parts of human body. Surface shapes of most contacting parts can be simplified as spherical caps, while there are few reports on relationship between sphere diameter and compression property of spacer fabric. Therefore, the main content dealt with in the paper was to conduct spherical compression and simulation analysis of warp-knitted spacer fabrics. Five spherical indenters were selected and three compression indices were featured. Comparisons of compression indices results of spacer fabrics amongst five spherical indenters exhibited good relations. Moreover, spherical compression behavior was simulated by finite element method to better understand the mechanism of spherical compression deformation of warp-knitted spacer fabrics. The results that relative errors of the compression indices were all small showed a good accordance between theoretical and experimental results; then, stress distribution and displacement evolutions were analyzed to discover deformation mechanism of spacer filaments compressed. It is effective to simulate the spherical compression performance between different parts of human body and spacer fabric.
Evaluation and selection of medical tourism sites: A rough analytic hierarchy process based multi‐attributive border approximation area comparison approach

This paper presents a novel Multiple Criteria Decision Making methodology for assessing and prioritizing medical tourism destinations under uncertainty. A systematic evaluation and assessment approach is proposed by incorporating analytic hierarchy process and multi‐attributive border approximation area comparison methods in the rough environment. Rough number is used to aggregate individual judgements of decision makers and express their true perception to handle vagueness without any prior information. Rough analytic hierarchy process analyses the relative importance of criteria based on their preferences given by experts, whereas rough multi‐attributive border approximation area comparison evaluates the alternative sites based on the criteria weights. A case study of prioritizing different sites (cities) in India for medical tourism services is shown to demonstrate the applicability of the proposed method. Among different criteria “quality of infrastructure of healthcare institutions” is observed to be the most important criteria in our analysis, followed by “supply of skilled human resources and new job creations” and “Chennai” is found to be the best medical tourism site in India. Finally, a comparative analysis and validity testing of the proposed method are elaborated, and the methodology provides a standard for select medical tourism sites on the basis of different criteria.
Fixed points and coincidence points for multimaps with not necessarily bounded images

In metric spaces, single-valued self-maps and multimaps with closed images are considered and fixed point and coincidence point theorems for such maps have been obtained without using the (extended) Hausdorff metric, thereby generalizing many results in the literature including those on the famous conjecture of Reich on multimaps.
Low-Complexity Energy-Efficient Resource Allocation for the Downlink of Cellular Systems

Energy efficiency (EE) is undoubtedly an important criterion for designing power-limited systems, and yet in a context of global energy saving, its relevance for power-unlimited systems is steadily growing. Equally, resource allocation is a well-known method for improving the performance of cellular systems. In this paper, we propose an EE optimization framework for the downlink of planar cellular systems over frequency-selective channels. Relying on this framework, we design two novel low-complexity resource allocation algorithms for the single-cell and coordinated multi-cell scenarios, which are EE-optimal and EE-suboptimal, respectively. We then utilize our algorithms for comparing the EE performance of the classic non-coordinated, orthogonal and coordinated multi-cell approaches in realistic power and system settings. Our results show that coordination can be a simple and effective method for improving the EE of cellular systems, especially for medium to large cell sizes. Indeed, by using a coordinated rather than a non-coordinated resource allocation approach, the per-sector energy consumption and transmit power can be reduced by up to 15% and more than 90%, respectively.
QTL mapping for microtuber dormancy and GA3 content in a diploid potato population

ABSTRACT The genetic control of dormancy is poorly understood in most plant species, but dormancy is a prominent feature for the potato industry. We used the microtuber system, in which tubers were produced in vitro and stored at 20°C, to perform quantitative trait locus (QTL) analysis for dormancy and gibberellic acid (GA3) content in an F1 population consisting of 178 genotypes derived from an interspecific cross between Solanum chacoense acc. PI 320285 (long dormancy) and Solanum phureja acc. DM1-3 516 R44 (short dormancy). In this analysis, 163 markers were used to construct a genetic map with a total length of 591.8 cM. Through QTL analysis, we identified 22 markers closely linked to the timing of dormancy release and GA3 content. The male parent alleles were closely related with long dormancy, with the most significant effect on chromosome I, which accounted for 9.4% of phenotypic variation. The dormancy and GA3 QTLs localized to the same position in the genome, confirming that same genomic region controls GA3 content at different developmental stages or in dormant and sprouting tubers. The identified QTLs may be useful for future breeding strategies and studies of dormancy in potato. Summary: Quantitative trait locus’ (QTLs) for dormancy and gibberellic acid production in potato are localized to the same genomic region in potato.