Miracle-dz/UniFAR-FTUs huggingface dataset:
NeuroIS: The Potential of Cognitive Neuroscience for Information Systems Research

This paper introduces the idea of drawing upon the cognitive neuroscience literature to inform IS research (herein termed “NeuroIS�? ). Recent advances in cognitive neuroscience are uncovering the neural bases of cognitive, emotional, and social processes, and they offer new insights into the complex interplay between IT and information processing, decision-making, and behavior among people, organizations, and markets. The paper reviews the emerging cognitive neuroscience literature to propose a set of seven opportunities that IS researchers can use to inform IS phenomena, namely (1) localizing the neural correlates of IS constructs, (2) capturing hidden mental processes, (3) complementing existing sources of IS data with brain data, (4) identifying antecedents of IS constructs, (5) testing consequences of IS constructs, (6) inferring the temporal ordering among IS constructs, and (7) challenging assumptions and enhancing IS theories. The paper proposes a framework for exploring the potential of cognitive neuroscience for IS research and offers examples of potentially fertile intersections of cognitive neuroscience and IS research in the domains of design science and human-computer interaction. This is followed by an example NeuroIS study in the context of e-commerce adoption using fMRI, which spawns interesting new insights. The challenges of using functional neuroimaging tools are also discussed. The paper concludes that there is considerable potential for using cognitive neuroscience theories and functional brain imaging tools in IS research to enhance IS theories.
Impact of non-inhibited platelet supplementation on platelet reactivity in patients treated with prasugrel or ticagrelor for an acute coronary syndrome: An ex vivo study

Abstract Managing bleeding in patients receiving P2Y12 inhibitors is challenging. Few data are available regarding the efficacy of platelet transfusion in patients treated with prasugrel or ticagrelor. The aim of this study was to evaluate the minimal amount of platelet supplementation (in terms of ratio of non-inhibited platelets to inhibited platelets) necessary to restore platelet reactivity in platelet-rich plasma (PRP) of patients treated with aspirin and a prasugrel or ticagrelor loading dose for an acute coronary syndrome. PRP samples from patients were mixed ex vivo with increasing proportions of pooled PRP from healthy volunteers. Platelet reactivity was challenged with adenosine diphosphate (ADP), arachidonic acid, collagen or thrombin receptor activating peptide using light transmission aggregometry. The primary endpoint was the proportion of patient samples recovering an ADP-induced maximal aggregation (ADP-Aggmax) value above 40%. In patients treated with prasugrel (n = 32), ADP-Aggmax increased progressively with supplements of pooled PRP, with an average increase of 7.9% (95% CI [7.1; 8.8], p < 0.001) per each 20% increase in the ratio of non-inhibited platelets to inhibited platelets. A ratio of 60% was associated with 90% of patients reaching the primary endpoint. In patients treated with ticagrelor (n = 15), ADP-Aggmax did not significantly increase with any level of supplements. In conclusions, ex vivo addition of non-inhibited platelets significantly improved ADP-Aggmax in patients treated with prasugrel with a dose-dependent effect. There was no evidence of such a reversal in patients treated with ticagrelor. These results suggest that platelet transfusion may be more effective in blunting bleeding in patients treated with prasugrel, than those treated with ticagrelor.
Determinants of sleep problems in patients with spondyloarthropathy.

OBJECTIVE To characterize sleep complaints and identify biopsychosocial factors associated with sleep problems in patients with spondyloarthropathy (SpA). METHODS The sample comprised 125 patients with SpA. Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI). Participants completed standardized questionnaires assessing depressed mood, perceived stress, leisure time physical activity, functional disability and disease activity. A series of hierarchical multiple regressions were computed to examine the determinants of the following sleep parameters: quality, latency, duration and efficiency. RESULTS The mean global PSQI score was 8.7 (SD = 5.0), with 69% of the sample classified as poor sleepers (PSQI global score >5). Worse functional status was associated with poorer sleep quality (p = 0.006), longer sleep latency (p = 0.004), shorter sleep duration (p = 0.001) and poorer sleep efficiency (p = 0.004). Higher depressed mood scores emerged in the multivariate analyses as a significant determinant of poorer sleep quality (p = 0.010), shorter sleep duration (p = 0.007) and poorer sleep efficiency (p = 0.006). Higher perceived stress was an independent contributor of poorer sleep quality (p = 0.033). The relationships between worse functional status and poorer sleep quality and shorter sleep duration were more pronounced for participants who completed the questionnaires in the English language. CONCLUSIONS Sleep problems are prevalent among patients with SpA. Our findings suggest that multiple factors are associated with sleep complaints in persons with SpA with functional status, depressed mood and stress differentially contributing to specific sleep parameters. Multimodal interventions, which include non-pharmacological methods targeting these biopsychosocial factors, require evaluation to optimize the management of sleep disruptions in SpA.
Circulating Endothelial Cells Are a Novel Marker of Cyclosporine-Induced Endothelial Damage

Abstract—Microvascular endothelial cells play a key role in transplant immunology. They are also important targets for calcineurin inhibitors. We recently demonstrated elevated numbers of circulating endothelial cells in renal transplant recipients with and without rejection in comparison with healthy controls. Because these patients received either cyclosporine or tacrolimus, we speculated that endothelial damage from calcineurin inhibitors might be responsible for these findings. In the present study, we tested the hypothesis that treatment with calcineurin inhibitors leads to an increase in circulating endothelial cells. We studied 57 renal transplant recipients: 19 on a calcineurin inhibitor–free immunosuppressive regimen and 38 patients on a standard immunosuppressive regimen, including cyclosporine, and matched them for age and serum creatinine. Endothelial cells were isolated from peripheral blood with anti-CD-146–coated immunomagnetic Dynabeads™ and were counted by fluorescence microscopy. Patients with cyclosporine therapy had elevated numbers of circulating endothelial cells (median 26, range 12 to 82 cells/mL) compared with healthy controls (median 6, range 0 to 82 cells/mL;P <0.001). Patients without calcineurin inhibitor treatment had significantly lower cell numbers (median 12, range 0 to 32 cells/mL;P <0.003) and were not significantly different from normal, untreated controls. In conclusion, renal transplant recipients who do not receive calcineurin inhibitors have significantly lower numbers of circulating endothelial cells than their age- and creatinine-matched counterparts who receive these drugs. We suggest that elevated numbers of circulating endothelial cells indicate damage from calcineurin inhibitors in renal transplant recipients and that circulating endothelial cells are a novel marker of endothelial damage.
Volumetric change of the graft bone after intertransverse fusion.

STUDY DESIGN Patients in whom good intertransverse fusion had been achieved were selected for the volumetric study of the fusion mass using sequential computed tomography scans. OBJECTIVES To assess the natural volumetric change of intertransverse fusion mass and the effect of the disease entity and spinal instrumentation on the fusion mass volume. SUMMARY OF BACKGROUND DATA The magnitude of volumetric change of the graft bone after intertransverse fusion is still inconclusive. METHODS Fifteen adult patients who underwent decompression surgery with single-level lumbar and lumbosacral intertransverse fusion were selected for this study. Preoperative diagnoses were degenerative spondylolisthesis in nine patients and isthmic spondylolisthesis in six. Seven of the 15 patients received pedicle screw fixation. They were categorized into two major groups: 1) instrumented and noninstrumented groups and 2) isthmic and degenerative groups. To assess the volumetric change of the graft bone, sequential computed tomography scans were obtained 2 weeks after surgery and again 18 months after surgery. RESULTS The overall initial mean graft volume was 6251 mm3, which decreased to 2842 mm3 by 18 months after surgery (P < 0.001). The overall mean volume loss between the two periods was 54.8% of the initial graft volume. Although there was no significant difference in the mean graft volume between the groups at either 2 weeks or 18 months after surgery (P > 0.05 in all comparisons), the mean graft volume in each group decreased significantly during the observation period (P < 0.01 in all comparisons). There was no significant difference in the mean volume loss or in the ratio of residual volume to the initial graft volume between the groups during the study period (P > 0.05 in all comparisons). The initial graft volume correlated positively with the graft volume at 18 months after surgery (r = 0.612, P < 0.01) and volume loss (r = 0.949, P < 0.01), but negatively with the residual volume ratio (r = -0.507, P < 0.01). CONCLUSIONS These results showed that more than one half of the initial graft bone volume was being absorbed during the consolidation processes of the graft bone, and that the volume loss during the period was not significantly affected by the spinal instrumentation or by the disease entity. It was also found that the greater the amount of the initial graft bone, the larger the fusion mass at 18 months after surgery. The volume loss, however, increased proportionally to an increase in the initial graft bone volume. The efficiency (ratio of residual volume to the initial graft volume) of the intertransverse fusion also tended to decline as the initial graft volume increased.
Predictors of Long-Term Adverse Outcomes in Patients With Congenital Coronary Artery Fistulae

Background—Significant morbidities, including angina, symptomatic heart failure, and myocardial infarction, have been reported after coronary artery fistula (CAF) closure; however, predictors that may be associated with adverse outcomes have not been established. The goal of this investigation is to describe the long-term outcomes witnessed in patients with either treated or untreated CAF at our institution and to investigate whether certain features predicted adverse outcomes. Methods and Results—The records and angiograms of patients with CAF who underwent a diagnostic cardiac catheterization at Children's Hospital Boston from 1959 through 2008 were reviewed. Of 76 patients identified, 20% were associated with additional congenital heart disease. Forty-four underwent transcatheter closure, 20 underwent surgical repair, and no intervention was performed in the remaining 12 subjects. Three patients who had initially undergone surgical closure had a second intervention, 1 underwent repeat surgery, and 2 underwent transcatheter closure. One patient who had undergone transcatheter closure underwent a second transcatheter closure for residual fistula. Major complications, including myocardial infarction, angina with coronary thrombosis, and symptomatic cardiomyopathy, occurred in 11 (15%) patients. The sole angiographic feature that was predictive of adverse outcome was drainage of the CAF into the coronary sinus (P<0.001). Clinical predictors associated with adverse outcomes included older age at diagnosis (P<0.001), tobacco use (P=0.006), diabetes (P=0.05), systemic hypertension (P<0.001), and hyperlipidemia (P<0.001). Conclusions—Long-term complications of CAF closure may include coronary thrombosis, myocardial infarction, and cardiomyopathy. CAF that drain into the coronary sinus are at particularly high-risk of long-term morbidities after closure, and strategies including long-term anticoagulation should be considered.
Dynamical Downscaling of Temperature and Precipitation Extremes in China under Current and Future Climates

ABSTRACT Climate changes over China from the present (1996–2005) to the future (2046–2055) under Representative Concentration Pathways 4.5 (RCP4.5) and Representative Concentration Pathways 8.5 (RCP8.5) scenarios are projected using the Weather Research and Forecasting (WRF) model, version 3.7. 1. The WRF model was driven by the Global 6-Hourly Bias-corrected Coupled Model Intercomparison Project, Phase 5 (CMIP5), Community Earth System Model dataset over China with a resolution of 30 km. The results demonstrate that WRF downscaling generally simulates more reliable spatial distributions of surface air temperature and precipitation in China with higher spatial pattern correlations and closer in magnitude to the Community Climate System Model, version 4.0, simulation results, especially near mountain ranges. The WRF projections for temperature and precipitation for the future under the two emission scenarios are compared with the present simulation. Generally stronger warming, both in mean temperature and extreme statistics, is produced by WRF-RCP8.5 than by WRF-RCP4.5. The projections for precipitation changes are more varied with season and region for both scenarios.
The Effects of Information and Communication Technologies on E-Business Performance: Designing a Path Analysis Framework

In today’s fast growing digital environment, firms are keen that their strategies should take advantage of the Internet’s capacity to access, organize and communicate information in fractions of cost involved before the Information and Communication Technology (ICT) revolution. Considering the vital role of strategic planning to business success, this paper proposes a path analytic framework to study the effects of ICT-driven strategies on economic performance. The theoretical framework identifies key qualitative factors for analyzing economic performance together with appropriate quantitative methods for providing useful measurements of these factors. Many of the e-business studies on gaining competitive advantage can be seen as specific instances of applying this framework-model for which this paper provides an empirical test for 202 e-firms operating in Greece. The maximum likelihood estimates of the model confirm a strong dynamic relationship between economic performance and ICT-driven strategic planning.
Using Strategic Movement to Calibrate a Neural Compass: A Spiking Network for Tracking Head Direction in Rats and Robots

The head direction (HD) system in mammals contains neurons that fire to represent the direction the animal is facing in its environment. The ability of these cells to reliably track head direction even after the removal of external sensory cues implies that the HD system is calibrated to function effectively using just internal (proprioceptive and vestibular) inputs. Rat pups and other infant mammals display stereotypical warm-up movements prior to locomotion in novel environments, and similar warm-up movements are seen in adult mammals with certain brain lesion-induced motor impairments. In this study we propose that synaptic learning mechanisms, in conjunction with appropriate movement strategies based on warm-up movements, can calibrate the HD system so that it functions effectively even in darkness. To examine the link between physical embodiment and neural control, and to determine that the system is robust to real-world phenomena, we implemented the synaptic mechanisms in a spiking neural network and tested it on a mobile robot platform. Results show that the combination of the synaptic learning mechanisms and warm-up movements are able to reliably calibrate the HD system so that it accurately tracks real-world head direction, and that calibration breaks down in systematic ways if certain movements are omitted. This work confirms that targeted, embodied behaviour can be used to calibrate neural systems, demonstrates that ‘grounding’ of modelled biological processes in the real world can reveal underlying functional principles (supporting the importance of robotics to biology), and proposes a functional role for stereotypical behaviours seen in infant mammals and those animals with certain motor deficits. We conjecture that these calibration principles may extend to the calibration of other neural systems involved in motion tracking and the representation of space, such as grid cells in entorhinal cortex.
Evaluation of a tobacco prevention programme among teenagers in Sweden

Objective To study the prevalence of tobacco use among teenagers, to evaluate a tobacco prevention programme and to study factors related to participation in the prevention programme. Design and setting Population-based prospective cohort study. Method Within the Obstructive Lung disease in Northern Sweden (OLIN) studies, a cohort study about asthma in schoolchildren started in 2006. All children aged 7–8 years in three municipalities were invited to a questionnaire survey and 2585 (96%) participated. The cohort was followed up at age 11–12 years (n=2612, 95% of invited) and 14–15 years (n=2345, 88% of invited). In 2010, some of the children in the OLIN cohort (n=447) were invited to a local tobacco prevention programme and 224 (50%) chose to participate. Results At the age of 14–15 years, the prevalence of daily smoking was 3.5%. Factors related to smoking were female sex, having a smoking mother, participation in sports and lower parental socioeconomic status (SES). The prevalence of using snus was 3.3% and risk factors were male sex, having a smoking mother, having a snus-using father and non-participation in the prevention programme. In the prevention programme, the prevalence of tobacco use was significantly lower among the participants compared with the controls in the cohort. Factors related to non-participation were male sex, having a smoking mother, lower parental SES and participation in sports. Conclusions The prevalence of tobacco use was lower among the participants in the tobacco prevention programme compared with the non-participants as well as with the controls in the cohort. However, the observed benefit of the intervention may be overestimated as participation was biased by selection.
Testing the statistics of dynamically downscaled rainfall data for the east coast of NSW

This study performs statistical analysis of downscaled rainfall data, concentrating on the attributes important for hydrology predictions used in reservoir reliability simulations, specifically long-term persistence and variability of the rainfall. The dataset used was produced by the NARCliM (NSW/ACT Regional Climate Modelling) project which provides high resolution (10km) dynamically downscaled climate data for south-eastern Australia. NARCliM has produced twelve ensembles of simulations for current and future climates as well as three simulations driven by the NCEP/NCAR reanalysis for the 60 year period 1950-2009. In this study, statistical testing results are presented for the three reanalysis datasets as well as the Australian Water Availability Project gridded (0.05 0.05 ) daily rainfall dataset. The validation has been performed for the Hunter region, which has a range of climate types (e.g. coastal, inland, rainshadow, East Coast Lows. The spatial variability of statistics of the NARCliM and AWAP gridded rainfall were calculated and plotted. An autocorrelation analysis was performed for daily, fortnightly, monthly and annual time resolutions. The autocorrelation analysis showed that all three reanalysis datasets overestimate the magnitude of the autocorrelations shown in AWAP; however the timing of the seasonal cycle is similar to that of AWAP. In order to understand the rainfall distribution of each dataset, cumulative probability distribution plots were also generated at the daily time resolution. These plots showed that NARCliM reanalyses overestimate the magnitude of rainfall at all probabilities.
Kinetic analysis reveals the ordered coupling of translation termination and ribosome recycling in yeast

Although well defined in bacterial systems, the molecular mechanisms underlying ribosome recycling in eukaryotic cells have only begun to be explored. Recent studies have proposed a direct role for eukaryotic termination factors eRF1 and eRF3 (and the related factors Dom34 and Hbs1) in downstream recycling processes; however, our understanding of the connection between termination and recycling in eukaryotes is limited. Here, using an in vitro reconstituted yeast translation system, we identify a key role for the multifunctional ABC-family protein Rli1 in stimulating both eRF1-mediated termination and ribosome recycling in yeast. Through subsequent kinetic analysis, we uncover a network of regulatory features that provides mechanistic insight into how the events of termination and recycling are obligately ordered. These results establish a model in which eukaryotic termination and recycling are not clearly demarcated events, as they are in bacteria, but coupled stages of the same release-factor mediated process.
Microboiling Measurements of Thermal-Inkjet Heaters

Microboiling occurs when a microheater covered by liquid is operated with microseconds pulse. As a result of the high heat flux, a vapor bubble is built up above the heater. This phenomenon is used for thermal inkjet as well as other applications. In this experimental study, the bubbles are traced and photographed. The evolution of the bubbles is shown from the first nucleation, through maximal volume of the bubble, until the final collapse of the bubble, together with parametric measurements. At the end of the heater lifetime, the heater cracking process is shown frame after frame, supported with simulations.