Miracle-dz/UniFAR-FTUs huggingface dataset:
IN VITRO INDUCTION OF SPECIFIC UNRESPONSIVENESS OF IMMUNOLOGICALLY REACTIVE, NORMAL BONE MARROW CELLS

Normal rabbit bone marrow cells have been studied according to their immunological reactivity in vitro. The test system involved stimulation by antigen after the subsequent stimulation into cellular proliferation by measuring the uptake of tritium-labeled thymidine. Specific separation of immunological reactivity was obtained by filtration of cells through antigen-coated bead columns. All experimental evidence supported the view that this separation was due to the existence of preformed antibody molecules on the outer cell surface of the antigen-recognizing cells. The response to antigenic stimulation was shown to be strictly dose related and, using supraoptimal concentrations of one antigen, no increased DNA synthesis was recorded. That this state of unresponsiveness represented a state of immunological paralysis was indicated by the normal response of these cells to stimulation by a second antigen in optimal concentration. Thus both methods, cell separation on antigen-coated columns or induction of specific unresponsiveness by antigen in vitro, can produce a cell population specifically devoid of cells reactive against a given antigen.
Regulation of NK cell activity : studies of DAP12-associated receptors in immune synapse formation and in responses to cytomegalovirus infection

Natural killer (NK) cell effector functions are important for innate resistance against tumor cells and viral infections. NK cells display a broad range of inhibitory and activating receptors on the cell surface, which ensure specificity. Several activating NK cell receptors are co-expressed with and function through the immunoreceptor tyrosinebased activation motif (ITAM)-bearing molecule DAP12. The general aim of this thesis was to address the role of a specific signaling pathway for activating NK cell receptors, the DAP12 pathway, in complex situations such as cellular or host-pathogen
Distinct Immunoglobulin Class and Immunoglobulin G Subclass Patterns against Ganglioside GQ1b in Miller Fisher Syndrome following Different Types of Infection

ABSTRACT We studied serum antibodies against gangliosides GQ1b and GM1 in 13 patients with Miller Fisher syndrome (MFS) and in 18 patients with Guillain-Barré syndrome (GBS) with cranial nerve involvement. Anti-GQ1b titers were elevated in all patients with MFS cases (immunoglobulin G [IgG] > IgA, IgM), and in 8 of the 18 with GBS. Lower frequencies of increased anti-GM1 titers were observed in MFS patients (3 of 13), as well as in GBS patients (5 of 18). During the course of MFS, anti-GQ1b titers of all Ig classes decreased within 3 weeks after onset. By contrast, anti-GM1 titers (mainly IgM) transiently increased during the course of MFS in five of six patients, suggesting a nonspecific secondary immune response. In patients with MFS following respiratory infections, IgG was the major anti-GQ1b Ig class (six of six patients) and IgG3 was the major subclass (five of six). In contrast, four of five patients with MFS following gastrointestinal infections showed predominance of anti-GQ1b IgA or IgM over IgG and predominance of the IgG2 subclass; anti-GQ1b IgG (IgG3) prevailed in one patient only. These distinct Ig patterns strongly suggest that different infections may trigger different mechanisms of anti-GQ1b production, such as via T-cell-dependent as opposed to T-cell-independent pathways. Thus, the origin of antibodies against GQ1b in MFS may be determined by the type of infectious agent that precipitates the disease.
Enterprise systems and ongoing process change

Enterprise systems packages have long been associated with process change. However, it was assumed that most organizations would simultaneously design and implement process change while implementing the systems. A survey of 163 organizations and detailed interviews with 28 more suggests that enterprise systems were still being implemented even among early adopters of the technology, and that process change was being undertaken on an ongoing basis. After the prerequisites of time, critical mass of functionality, and significant expenditures were taken care of, the factors most associated with achieving value from enterprise systems were integration, process optimization, and use of enterprise‐systems data in decision making.
Subtyping binge eating-disordered women along dieting and negative affect dimensions.

OBJECTIVE Because etiologic and maintenance models of binge eating center around dieting and affect regulation, this study tested whether binge eating-disordered (BED) individuals could be subtyped along dieting and negative affect dimensions and whether subtypes differed in eating pathology, social functioning, psychiatric comorbidity, and response to treatment. METHOD Three independent samples of interviewer-diagnosed BED women (N = 218) were subtyped along dieting and negative affect dimensions using cluster analysis and compared on the outcomes of interest. RESULTS Cluster analyses replicated across the three independent samples and revealed a dietary subtype (63%) and a dietary-depressive subtype (37%). The latter subtype reported greater eating and weight obsessions, social maladjustment, higher lifetime rates of mood, anxiety, and personality disorders, and poorer response to treatment than did the dietary subtype. DISCUSSION Results suggest that moderate dieting is a central feature of BED and that affective disturbances occur in only a subset of cases. However, the confluence of dieting and negative affect signals a more severe variant of the disorder marked by elevated psychopathology, impaired social functioning, and a poorer treatment response.
Finite-Time $H_{\infty }$ Filtering for T–S Fuzzy Discrete-Time Systems With Time-Varying Delay and Norm-Bounded Uncertainties

In this paper, we investigate the filtering problem of discrete-time Takagi-Sugeno (T-S) fuzzy uncertain systems subject to time-varying delays. A reduced-order filter is designed. With the augmentation technique, a filtering error system with delayed states is obtained. In order to deal with time delays in system states, the filtering error system is first transformed into two interconnected subsystems. By using a two-term approximation for the time-varying delay, sufficient delay-dependent conditions of finite-time boundedness and H∞ performance of the filtering error system are derived with the Lyapunov function. Based on these conditions, the filter design methods are proposed and the filter gain matrices can be obtained by calculating a set of linear matrix inequalities. A numerical example is used to illustrate the effectiveness of the proposed approaches.
Association of socioeconomic position with health behaviors and mortality.

CONTEXT Previous studies may have underestimated the contribution of health behaviors to social inequalities in mortality because health behaviors were assessed only at the baseline of the study. OBJECTIVE To examine the role of health behaviors in the association between socioeconomic position and mortality and compare whether their contribution differs when assessed at only 1 point in time with that assessed longitudinally through the follow-up period. DESIGN, SETTING, AND PARTICIPANTS Established in 1985, the British Whitehall II longitudinal cohort study includes 10 308 civil servants, aged 35 to 55 years, living in London, England. Analyses are based on 9590 men and women followed up for mortality until April 30, 2009. Socioeconomic position was derived from civil service employment grade (high, intermediate, and low) at baseline. Smoking, alcohol consumption, diet, and physical activity were assessed 4 times during the follow-up period. MAIN OUTCOME MEASURES All-cause and cause-specific mortality. RESULTS A total of 654 participants died during the follow-up period. In the analyses adjusted for sex and year of birth, those with the lowest socioeconomic position had 1.60 times higher risk of death from all causes than those with the highest socioeconomic position (a rate difference of 1.94/1000 person-years). This association was attenuated by 42% (95% confidence interval [CI], 21%-94%) when health behaviors assessed at baseline were entered into the model and by 72% (95% CI, 42%-154%) when they were entered as time-dependent covariates. The corresponding attenuations were 29% (95% CI, 11%-54%) and 45% (95% CI, 24%-79%) for cardiovascular mortality and 61% (95% CI, 16%-425%) and 94% (95% CI, 35%-595%) for noncancer and noncardiovascular mortality. The difference between the baseline only and repeated assessments of health behaviors was mostly due to an increased explanatory power of diet (from 7% to 17% for all-cause mortality, respectively), physical activity (from 5% to 21% for all-cause mortality), and alcohol consumption (from 3% to 12% for all-cause mortality). The role of smoking, the strongest mediator in these analyses, did not change when using baseline or repeat assessments (from 32% to 35% for all-cause mortality). CONCLUSION In a civil service population in London, England, there was an association between socioeconomic position and mortality that was substantially accounted for by adjustment for health behaviors, particularly when the behaviors were assessed repeatedly.
On Selection of Modulus of Quadratic Codes for the Protection of Cryptographic Operations against Fault Attacks

Quadratic residue codes are introduced as an effective and efficient fault detection technique to protect cryptographic devices against fault attacks. In this paper, we re-consider these codes in an adversarial model, where a powerful attacker can introduce faults with high precision and accuracy. We present two analysis techniques that can lead to successful attacks against quadratic codes if the modulus is not chosen carefully. We provide in-depth theoretical analysis that covers wide range of attacks and present results of practical concerns such as exact number of undetected faults and effective countermeasures. Our analysis is generic in the sense that it can be extended to other residue codes.
A new keyword spotting algorithm with pre-calculated optimal thresholds

Keyword spotting is a very forward looking and promising branch of speech recognition. The paper presents a HMM based keyword spotting system, which works with a new algorithm. The first discussion topic is the description of the search algorithm, that needs no representation of the non keyword parts of the speech signal. For this purpose, the computation of the HMM scores and the Viterbi algorithm had to be modified. The keyword HMMs are not concatenated with other HMMs, so that there is no necessity for filler or garbage models. As a further advantage, this algorithm needs only low computational expense and storage requirement. The second discussion topic is the determination of a optimal decision threshold for each keyword. In order to decide between the two possibilities "keyword was spoken" and "keyword was not spoken", the scores of the keywords are compared with keyword specific decision thresholds. The paper introduces a method to fix decision thresholds in advance. Starting with measured phoneme distributions, the score distributions of whole keyword models can be calculated. Furthermore, these keyword distributions form the basis of the computation of decision thresholds. Tests with spontaneous speech databases yielded 73.9% Figure Of Merit when using context dependent HMMs. The detection rate at 10 fa/kw/h comes to 80%.
Loss of Heterozygosity and Its Correlation with Expression Profiles in Subclasses of Invasive Breast Cancers

Gene expression array profiles identify subclasses of breast cancers with different clinical outcomes and different molecular features. The present study attempted to correlate genomic alterations (loss of heterozygosity; LOH) with subclasses of breast cancers having distinct gene expression signatures. Hierarchical clustering of expression array data from 89 invasive breast cancers identified four major expression subclasses. Thirty-four of these cases representative of the four subclasses were microdissected and allelotyped using genome-wide single nucleotide polymorphism detection arrays (Affymetrix, Inc.). LOH was determined by comparing tumor and normal single nucleotide polymorphism allelotypes. A newly developed statistical tool was used to determine the chromosomal regions of frequent LOH. We found that breast cancers were highly heterogeneous, with the proportion of LOH ranging widely from 0.3% to >60% of heterozygous markers. The most common sites of LOH were on 17p, 17q, 16q, 11q, and 14q, sites reported in previous LOH studies. Signature LOH events were discovered in certain expression subclasses. Unique regions of LOH on 5q and 4p marked a subclass of breast cancers with “basal-like” expression profiles, distinct from other subclasses. LOH on 1p and 16q occurred preferentially in a subclass of estrogen receptor-positive breast cancers. Finding unique LOH patterns in different groups of breast cancer, in part defined by expression signatures, adds confidence to newer schemes of molecular classification. Furthermore, exclusive association between biological subclasses and restricted LOH events provides rationale to search for targeted genes.
Organellar Inheritance in the Green Lineage: Insights from Ostreococcus tauri

Along the green lineage (Chlorophyta and Streptophyta), mitochondria and chloroplast are mainly uniparentally transmitted and their evolution is thus clonal. The mode of organellar inheritance in their ancestor is less certain. The inability to make clear phylogenetic inference is partly due to a lack of information for deep branching organisms in this lineage. Here, we investigate organellar evolution in the early branching green alga Ostreococcus tauri using population genomics data from the complete mitochondrial and chloroplast genomes. The haplotype structure is consistent with clonal evolution in mitochondria, while we find evidence for recombination in the chloroplast genome. The number of recombination events in the genealogy of the chloroplast suggests that recombination, and thus biparental inheritance, is not rare. Consistent with the evidence of recombination, we find that the ratio of the number of nonsynonymous to the synonymous polymorphisms per site is lower in chloroplast than in the mitochondria genome. We also find evidence for the segregation of two selfish genetic elements in the chloroplast. These results shed light on the role of recombination and the evolutionary history of organellar inheritance in the green lineage.
Probabilistic and Statistical Properties of Words: An Overview

In the following, an overview is given on statistical and probabilistic properties of words, as occurring in the analysis of biological sequences. Counts of occurrence, counts of clumps, and renewal counts are distinguished, and exact distributions as well as normal approximations, Poisson process approximations, and compound Poisson approximations are derived. Here, a sequence is modelled as a stationary ergodic Markov chain; a test for determining the appropriate order of the Markov chain is described. The convergence results take the error made by estimating the Markovian transition probabilities into account. The main tools involved are moment generating functions, martingales, Stein's method, and the Chen-Stein method. Similar results are given for occurrences of multiple patterns, and, as an example, the problem of unique recoverability of a sequence from SBH chip data is discussed. Special emphasis lies on disentangling the complicated dependence structure between word occurrences, due to self-overlap as well as due to overlap between words. The results can be used to derive approximate, and conservative, confidence intervals for tests.
Selectional Preferences for Semantic Role Classification

This paper focuses on a well-known open issue in Semantic Role Classification (SRC) research: the limited influence and sparseness of lexical features. We mitigate this problem using models that integrate automatically learned selectional preferences (SP). We explore a range of models based on WordNet and distributional-similarity SPs. Furthermore, we demonstrate that the SRC task is better modeled by SP models centered on both verbs and prepositions, rather than verbs alone. Our experiments with SP-based models in isolation indicate that they outperform a lexical baseline with 20 F1 points in domain and almost 40 F1 points out of domain. Furthermore, we show that a state-of-the-art SRC system extended with features based on selectional preferences performs significantly better, both in domain (17% error reduction) and out of domain (13% error reduction). Finally, we show that in an end-to-end semantic role labeling system we obtain small but statistically significant improvements, even though our modified SRC model affects only approximately 4% of the argument candidates. Our post hoc error analysis indicates that the SP-based features help mostly in situations where syntactic information is either incorrect or insufficient to disambiguate the correct role.
Proper affine actions and geodesic flows of hyperbolic surfaces

Let To C 0(2,1) be a Schottky group, and let ? = H2/ To be the corresponding hyperbolic surface. Let ^(S) denote the space of unit length geodesic currents on S. The cohomology group if1 (To, V) parametrizes equivalence classes of affine deformations Tu of To acting on an irreducible representation V of 0(2,1). We define a continuous biaffine map *I> : ^(S) x Hl(To, V) ? > U which is linear on the vector space H1(Fo, V). An affine deformation Tu acts properly if and only if *(/x, [u]) 7^ 0 for all /jl e ^(S). Consequently the set of proper affine actions whose linear part is a Schottky group identifies with a bundle of open convex cones in Hl (To, V) over the Fricke-Teichmiiller space of E.
Cardiovascular Thrombotic Events in Controlled, Clinical Trials of Rofecoxib

Background—In comparing aspirin, nonselective nonsteroidal antiinflammatory agents (NSAIDs), and cyclooxygenase (COX)-2 inhibitors, variation in platelet inhibitory effects exists that may be associated with differential risks of cardiovascular (CV) thrombotic events. Among the randomized, controlled trials with the COX-2 inhibitor rofecoxib, one study demonstrated a significant difference between rofecoxib and its NSAID comparator (naproxen) in the risk of CV thrombotic events. A combined analysis of individual patient data was undertaken to determine whether there was an excess of CV thrombotic events in patients treated with rofecoxib compared with those treated with placebo or nonselective NSAIDs. Methods and Results—CV thrombotic events were assessed across 23 phase IIb to V rofecoxib studies. Comparisons were made between patients taking rofecoxib and those taking either placebo, naproxen (an NSAID with near-complete inhibition of platelet function throughout its dosing interval), or another nonselective NSAIDs used in the development program (diclofenac, ibuprofen, and nabumetone). The major outcome measure was the combined end point used by the Antiplatelet Trialists’ Collaboration, which includes CV, hemorrhagic, and unknown deaths; nonfatal myocardial infarctions; and nonfatal strokes. More than 28 000 patients, representing >14 000 patient-years at risk, were analyzed. The relative risk for an end point was 0.84 (95% CI: 0.51, 1.38) when comparing rofecoxib with placebo; 0.79 (95% CI: 0.40, 1.55) when comparing rofecoxib with non-naproxen NSAIDs; and 1.69 (95% CI: 1.07, 2.69) when comparing rofecoxib with naproxen. Conclusions—This analysis provides no evidence for an excess of CV events for rofecoxib relative to either placebo or the non-naproxen NSAIDs that were studied. Differences observed between rofecoxib and naproxen are likely the result of the antiplatelet effects of the latter agent.
Anesthetic‐and heat‐induced sudden death in calsequestrin‐1‐knockout mice

CaIsequestrin‐1 (CASQ1) is a moderate‐affinity, high‐capacity Ca2+‐binding protein in the sarcoplasmic reticulum (SR) terminal cisternae of skeletal muscle. CASQ1 functions as both a Ca2+‐binding protein and a luminal regulator of ryanodine receptor (RYR1)‐mediated Ca2+ release. Mice lacking skeletal CASQ1 are viable but exhibit reduced levels of releasable Ca2+ and altered contractile properties. Here we report that CASQ1‐null mice exhibit increased spontaneous mortality and susceptibility to heat‐and anesthetic‐induced sudden death. Exposure of CASQ1‐null mice to either 2% halo‐thane or heat stress triggers lethal episodes characterized by whole‐body contractures, elevated core temperature, and severe rhabdomyolysis, which are prevented by prior dantrolene administration. The characteristics of these events are remarkably similar to analogous episodes observed in humans with malignant hyperthermia (MH) and animal models of MH and environmental heat stroke (EHS). In vitro studies indicate that CASQ1‐null muscle exhibits increased contractile sensitivity to temperature and caffeine, temperature‐dependent increases in resting Ca2+, and an increase in the magnitude of depolarization‐induced Ca2+ release. These results demonstrate that CASQ1 deficiency alters proper control of RYR1 function and suggest CASQ1 as a potential candidate gene for linkage analysis in families with MH/EHS where mutations in the RYR1 gene are excluded. —Dainese, M. ,Quarta, M. , Lyfenko, A.D., Paolini, C. , Canato, M. , Reggiani, C. , Dirksen, R.T. , Protasi, F. Anesthetic‐and heat‐induced sudden death incalsequestrin‐1‐knockout mice. FASEB J. 23, 1710–1720 (2009)
Estimating endogenous amino acid flows at the terminal ileum and true ileal amino acid digestibilities in feedstuffs for growing pigs using the homoarginine method.

True ileal lysine digestibilities were determined using the homoarginine (HA) method in casein-, barley-, canola meal-, and barley-canola meal-based diets fed to growing pigs. Four Yorkshire barrows (25 to 49 kg BW) equipped with ileal T-cannulas were fed one of the diets according to a 4 x 4 Latin square design. All diets, except for the barley diet, were formulated to be similar in DE:CP ratio. Ileal digesta were collected continuously for 24 h on d 7 and 9 of each experimental period for determining apparent and true ileal digestibilities, respectively. True ileal lysine digestibility and endogenous flows were determined by feeding diets in which 50% of the protein-containing ingredients was guanidinated; the conversion of lysine to HA allows for direct determination of true lysine digestibilities. The apparent ileal CP and amino acid digestibilities were higher (P < .05) in the casein diet than in the barley, canola meal, and barley-canola meal diets. The CP digestibility was higher (P < .05) in the barley-canola meal diet than in the barley and canola meal diets. Endogenous lysine losses were influenced by diet (P < .05) and ranged between 586 and 1,429 mg/kg DM intake. True ileal lysine digestibilities in barley, canola meal, and barley-canola meal diets were similar (P > .05) and lower (P < .05) than in the casein diet. The true ileal amino acid digestibilities were estimated for other amino acids. Unlike apparent digestibilities, true digestibilities seemed additive in the barley-canola meal mixture.
The history and use of diamond

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