Miracle-dz/UniFAR-FTUs huggingface dataset:
Role of blood gas analysis during cardiopulmonary resuscitation in out-of-hospital cardiac arrest patients

AbstractTo determine the relationship between acid–base findings, such as pH, pCO2, and serum lactate levels, obtained immediately after starting cardiopulmonary resuscitation and the return of spontaneous circulation (ROSC). A prospective observational study of adult, nontraumatic out-of-hospital cardiac arrest (OHCA) patients was conducted at an urban academic teaching institution between April 1, 2013 and March 31, 2015. Arterial blood sample for acid–base data was taken from all OHCA patients on arrival to the emergency department. Of 224 OHCA patients, 88 patients with unavailable blood samples or delayed blood sampling or ROSC within 4 minutes were excluded, leaving 136 patients for analysis.The pH in the ROSC group was significantly higher than in the non-ROSC group (6.96 vs. 6.85; P = 0.009). pCO2 and lactate levels in the ROSC group were significantly lower than those in the non-ROSC group (74.0 vs. 89.5 mmHg, P < 0.009; 11.6 vs. 13.6 mmol/L, P = 0.044, respectively). In a multivariate regression analysis, pCO2 was the only independent biochemical predictor for sustained ROSC (OR 0.979; 95% CI 0.960–0.997; P = 0.025) and pCO2 of <75 mmHg was 3.3 times more likely to achieve ROSC (OR 0.302; 95% CI 0.146–0.627; P = 0.001). pCO2 levels obtained during cardiopulmonary resuscitation on ER arrival was associated with ROSC in OHCA patients. It might be a potentially marker for reflecting the status of the ischemic insult. These preliminary results need to be confirmed in a larger population.
Impact of thalamic deep brain stimulation on disability and health-related quality of life in patients with essential tremor

Objectives: To evaluate the impact of thalamic deep brain stimulation (DBS) on disability and health-related quality of life in patients with essential tremor. Methods: Twenty seven consecutive patients were evaluated prospectively, before surgery and at a mean of 12 months (range 6–26) after thalamic DBS. Assessment tools included the Fahn-Tolosa-Marìn tremor rating scale (TRS), activities of daily living (ADL) taxonomy, Nottingham health profile (NHP) and the visual analogue scale (VAS) for measuring impact of disease on life. Additional information on the side effects of, and expectations from surgery was obtained by interview. Results: Thalamic DBS improved the ability of the patients in eating, drinking, writing, home maintenance, hobbies, and participation in society. Activities of daily life requiring bimanual skills were less improved. The emotional condition of the patients was positively affected and the negative impact of the disease on life as a whole, and on social life was decreased. Seventy per cent of the patients considered that the surgical treatment met their expectations. Conclusions: After thalamic DBS, health-related quality of life including disability in ADL and social life were improved in patients with essential tremor.
Creative Intelligence: Discovering the Innovative Potential in Ourselves and Others

Preface. 1. Finding Our Creative Intelligence. Why Is the Study of Creativity Critical? What, Then, Is Creativity? The Four Styles of Creative Intelligence. Intuitive. Innovative. Imaginative. Inspirational. How Do We Identify a Person's Creative Intelligence? General Intelligence vs Creative Intelligence. What About Our Ancestors? Can We Measure Creative Intelligence? What Is the Creative Potential Profile? Other Views of Creativity. Who, Then, Is Creative? Environmental Influences on Creativity. Kinds of Creativity. The Many Faces of Creativity. The Role of Personality in Creativity. Can We Really Understand Creativity? 2. Finding Your Creative Potential. Why Is Creativity Important? How Do We Use Creative Intelligence? How We See the World. Cognition and Creativity. Creative Visualization. The Creative Potential Profile. Intuitive. Innovative. Imaginative. Inspirational. The Creative Potential Profile Test Instrument. Personality Traits. What Leads to Creativity? Applying the Creative Potential Profile. 3. What Can We Learn From Creative Individuals? Those Who Create. How to Enhance Creativity. Exploring the Creative Process. Nobel Prize Winners. What Is Different About Creative Individuals? Creativity Is Not Affected by Age. What Can We Learn from These Outstanding Individuals? A Sampling of Creative Individuals. Katherine Hepburn. Rembrandt van Rijn. Jean Piaget. William Shakespeare. What Have We Learned? 4. Using Our Creative Ability. Creative Problem-Solving. How We See Problems. Finding Solutions. How Are Problems Defined? A Problem-Solving Example. Where Does Creative Problem-Solving Start? Approaches to Creative Problem-Solving. Other Approaches to Creative Problem-Solving. Is Creative Problem-Solving Possible? The Brain: A Key to Understanding Creative Intelligence. How the Brain Functions. Understanding the Brain. The Brain and Reality. 5. Applying Creativity to Education. Creativity in Education. How Education Is Viewed. The Tradition of the Active Mind. Problems Confronting Education. How Do We Learn? How Education Is Changing. New Approaches to Learning. Introducing Change in Education. Differences in Students. Learning Theory. Testing and Learning. The Relationship Between Math and Music. The Environment and Education. Can Computers Enhance Education? The Role of Technology in Education. Teacher Involvement with Distance Learning. Alternative Schools. Where Do We Go from Here? 6. The Challenge of the Future. Drivers of the Future. How Creative Leaders Function. How Change Is Introduced. Organizational Change. Creativity and Organizational Culture. Creativity at Work. The Importance of Creative Individuals. How Creative People Behave. Applying Creativity. The Future Is Now. Bibliography. Index.
Visualizing the Essential Role of Complete Virion Assembly Machinery in Efficient Hepatitis C Virus Cell-to-Cell Transmission by a Viral Infection-Activated Split-Intein-Mediated Reporter System

ABSTRACT Hepatitis C virus (HCV) infects 2 to 3% of the world population and is a leading cause of liver diseases such as fibrosis, cirrhosis, and hepatocellular carcinoma. Many aspects of HCV study, ranging from molecular virology and antiviral drug development to drug resistance profiling, were supported by straightforward assays of HCV replication and infection. Among these assays, the HCV-dependent fluorescence relocalization (HDFR) system allowed live-cell visualization of infection without modifying the viral genome, but this strategy required careful recognition of the fluorescence relocalization pattern for its high fluorescence background in the cytoplasm. In this study, to achieve background-free visualization of HCV infection, a viral infection-activated split-intein-mediated reporter system (VISI) was devised. Uninfected Huh7.5. 1-VISI cells show no background signal, while HCV infection specifically illuminates the nuclei of infected Huh7.5. 1-VISI cells with either green fluorescent protein (GFP) or mCherry. Combining VISI-GFP and VISI-mCherry systems, we revisited HCV cell-to-cell transmission with clear-cut distinction of donor and recipient cells in a live-cell manner. Independently of virion assembly, exosomes have been reported to transfer HCV subgenomic RNA to initiate replication in uninfected cells, which suggested an assembly-free pathway. However, our data demonstrated that HCV structural genes and the p7 gene were essential for not only cell-free infectivity but also cell-to-cell transmission. Additionally, depletion of apolipoprotein E (ApoE) from donor cells but not from recipient cells significantly reduced HCV cell-to-cell transmission efficiency. In summary, we developed a background-free cell-based reporter system for convenient live-cell visualization of HCV infection, and our data indicate that complete HCV virion assembly machinery is essential for both cell-free and cell-to-cell transmission. IMPORTANCE Hepatitis C virus (HCV) infects hepatocytes via two pathways: cell-free infection and cell-to-cell transmission. Structural modules of the HCV genome are required for production of infectious cell-free virions; however, the role of specific genes within the structural module in cell-to-cell transmission is not clearly defined. Our data demonstrate that deletion of core, E1E2, and p7 genes individually results in no HCV cell-to-cell transmission and that ApoE knockdown from donor cells causes less-efficient cell-to-cell transmission. Thus, this work indicates that the complete HCV assembly machinery is required for HCV cell-to-cell transmission. At last, this work presents an optimized viral infection-activated split-intein-mediated reporter system for easy live-cell monitoring of HCV infection.
Anomalous system call detection

Intrusion detection systems (IDSs) are used to detect traces of malicious activities targeted against the network and its resources. Anomaly-based IDSs build models of the expected behavior of applications by analyzing events that are generated during the applications' normal operation. Once these models have been established, subsequent events are analyzed to identify deviations, on the assumption that anomalies represent evidence of an attack. Host-based anomaly detection systems often rely on system call sequences to characterize the normal behavior of applications. Recently, it has been shown how these systems can be evaded by launching attacks that execute legitimate system call sequences. The evasion is possible because existing techniques do not take into account all available features of system calls. In particular, system call arguments are not considered. We propose two primary improvements upon existing host-based anomaly detectors. First, we apply multiple detection models to system call arguments. Multiple models allow the arguments of each system call invocation to be evaluated from several different perspectives. Second, we introduce a sophisticated method of combining the anomaly scores from each model into an overall aggregate score. The combined anomaly score determines whether an event is part of an attack. Individual anomaly scores are often contradicting and, therefore, a simple weighted sum cannot deliver reliable results. To address this problem, we propose a technique that uses Bayesian networks to perform system call classification. We show that the analysis of system call arguments and the use of Bayesian classification improves detection accuracy and resilience against evasion attempts. In addition, the paper describes a tool based on our approach and provides a quantitative evaluation of its performance in terms of both detection effectiveness and overhead. A comparison with four related approaches is also presented.
Strengthening of RC Beams Using Externally Bonded Reinforcement Combined with Near-Surface Mounted Technique

This study investigates the flexural behaviour of reinforced concrete (RC) beams strengthened through the combined externally bonded and near-surface mounted (CEBNSM) technique. The externally bonded reinforcement (EBR) and near-surface mounted (NSM) techniques are popular strengthening solutions, although these methods often demonstrate premature debonding failure. The proposed CEBNSM technique increases the bond area of the concrete–carbon fibre reinforced polymer (CFRP) interface, which can delay the debonding failure. This technique is appropriate when any structure has a narrow cross-sectional width or is in need of additional flexural capacity that an individual technique or material cannot attain. An experimental test matrix was designed with one control and five strengthened RC beams to verify the performance of the proposed technique. The strengthening materials were CFRP bar as NSM reinforcement combined with CFRP fabric as EBR material. The test variables were the diameter of the NSM bars (8 and 10 mm), the thickness of the CFRP fabrics (one and two layers) and the U-wrap anchorage. The strengthened beams showed enhancement of ultimate load capacity, stiffness, cracking behaviour, and strain compatibility. The ultimate capacity of the CEBNSM-strengthened beams increased from 71% to 105% compared to that of the control beam. A simulation method based on the moment-rotation approach was also presented to predict the behaviour of CEBNSM-strengthened RC beams.
Aberrant p53 expression correlates with expression of vascular endothelial growth factor mRNA and interleukin-8 mRNA and neoangiogenesis in non-small-cell lung cancer.

PURPOSE To evaluate interactions between expressions of tumor suppressor gene p53 and angiogenic factors vascular endothelial cell growth factor (VEGF) and interleukin-8 (IL-8) and their effect on tumor angiogenesis and patient prognosis in non--small-cell lung cancer (NSCLC). PATIENTS AND METHODS p53, VEGF, IL-8, and the microvessel endothelium were immunostained, and VEGF and IL-8 mRNA expression were quantified using the real-time quantitative reverse-transcription polymerase chain reaction in 65 NSCLC surgical specimens. Aberrant p53 expression was correlated with VEGF and IL-8 mRNA expression, microvessel count (MVC), other clinical-pathologic variables, and patients' survival. RESULTS Tumors with high aberrant p53 expression showed significantly higher VEGF and IL-8 mRNA expression and MVC than those with low aberrant p53 expression (P <.001). When tested as a continuous variable, aberrant p53 expression correlated strongly and positively with VEGF and IL-8 mRNA expression and MVC (P <.0001). Tumors with high aberrant p53 expression were associated with mediastinal or distant lymph node metastasis (P =.006). Survival and postoperative relapse time were significantly shorter in patients with high aberrant p53 expression tumors than in those with low aberrant expression tumors (P <.0001). A significant difference in survival was also seen between patients with high and low tumoral VEGF mRNA expression and between those with high and low tumoral IL-8 mRNA expression (P <.0001). CONCLUSION We report here for the first time that aberrant p53 expression is strongly positively correlated with VEGF mRNA and IL-8 mRNA expression in NSCLC. This result indicates that aberrant p53 expression may play a significant role in regulation of VEGF and IL-8 expression and be involved in controlling angiogenesis and explains the adverse prognosis of cancers with high aberrant p53 expression.
Genetic variation over space and time: analyses of extinct and remnant lake trout populations in the Upper Great Lakes

Lake trout (Salvelinus namaycush) in the upper Laurentian Great Lakes of North America experienced striking reductions in abundance and distribution during the mid–twentieth century. Complete collapse of populations was documented for Lake Michigan, and a few remnant populations remained only in lakes Huron and Superior. Using DNA obtained from historical scale collections, we analysed patterns of genetic diversity at five microsatellite loci from archived historical samples representing 15 populations (range 1940–1959) and from three contemporary remnant populations across lakes Huron and Superior (total n = 893). Demographic declines in abundance and the extirpation of native lake trout populations during the past 40 years have resulted in the loss of genetic diversity between lakes owing to extirpation of Lake Michigan populations and a temporal trend for reduction in allelic richness in the populations of lakes Superior and Huron. Naturally reproducing populations in Lake Superior, which had been considered to be remnants of historical populations, and which were believed to be responsible for the resurgence of lake trout numbers and distribution, have probably been affected by hatchery supplementation.
Effects of Low- and High-Flux Dialyzers on Oxidative Stress and Insulin Resistance

Background: Cardiovascular disease (CVD) is the leading cause of mortality in patients with end-stage renal disease (ESRD). The cornerstone of high CVD incidence in ESRD patients is endothelial dysfunction which results from inflammation, oxidative stress and insulin resistance. Although various modalities of hemodialysis (HD) have been presumed to exert different effects on oxidative stress and insulin resistance, solid evidence is still lacking. Methods: 40 ESRD patients undergoing HD were prospectively enrolled and divided randomly into two groups. Patients in each group received either F8 HPS (low-flux) (Group A) or FX80 (high-flux) (Group B) as HD dialyzers for 2 consecutive months. Diet pattern and medications were kept as usual in both groups to avoid considerable blood glucose change during study period. Blood samples were taken at the start and end of the study. Results: A total of 38 patients (18 and 20 for Groups A and B, respectively) completed the study. Within each group, there was no change in adiponectin, plasma 8-iso-prostaglandin F2α, high-sensitivity C-reactive protein, blood glucose and insulin after 2 months of treatment except a significant change of HOMAIR (p = 0.02) in high-flux group. The significant change of HOMAIR between the two groups (p = 0.017) mainly results from the parallel change of insulin between the two groups (p = 0.03). Conclusion: For patients receiving HD, the high-flux dialyzer with synthetic polysulfone membranes fails to provide a better anti-inflammatory or antioxidative effect than the low-flux dialyzer; however, the high-flux dialyzer does significantly improve insulin resistance in this short-term study. This result implies that the high-flux dialyzer might provide better cardiovascular protection than the low-flux dialyzer. Therefore, the low-flux dialyzer might be considered for patients who only need short-term HD therapy. Regarding patients under long-term maintenance HD therapy, a high-flux dialyzer might be the choice of dialyzer.
Positive affect and life satisfaction in Australian adolescents

[Abstract]: Adolescents are disproportionately affected by mental health conditions (Vimpani, Patton, & Hayes, 2002), and one of the key missions of this century is to create a science of human strengths (Seligman & Peterson, 2001) by better understanding those factors that contribute to positive life outcomes for young people. The Broaden-and-Build Theory of positive emotions (Fredrickson, 1998) provided a framework for examining the relationship between positive emotions and psychological well-being in Australian adolescents. This theory asserts that positive emotions exist to solve problems concerned with personal growth and development, and that positive emotions produce upward spirals of well-being. Study 1 investigated the hypothesis that the variables Broadened Mindset, Self-Efficacy, and Life Meaning mediated the relationship between Positive Affect and Life Satisfaction. Data indicated that Broadened Mindset and Self-Efficacy variables partially mediated this relationship. These findings support Fredrickson’s Broaden-and-Build theory, as well as previous research linking feelings of self-efficacy to psychological well-being (Bandura, 1992). Study 2 examined the effect of a youth program, the National Leadership Camp (NLC, Rising Generations, 2006), on participants’ levels of Life Satisfaction, Positive Affect, Broadened Mindset, and Self- Efficacy over a 3 month period. It was found that participants attending the NLC had significantly higher levels of Life Satisfaction, Positive Affect, and Broadened Mindset following attendance at the NLC; however these significant gains were not maintained over a three month time period. This data suggests that the youth program succeeded in influencing adolescent well-being briefly, however further research is required to investigate how to maintain these improvements in the long-term.
Model parameter estimation for mixture density polynomial segment models

In this paper, we propose parameter estimation techniques for mixture density polynomial segment models (MDPSM) where their trajectories are specified with an arbitrary regression order. MDPSM parameters can be trained in one of three different ways: (1) segment clustering, (2) expectation maximization (EM) training of mean trajectories, or (3) EM training of mean and variance trajectories. These parameter estimation methods were evaluated in TIMIT vowel classification experiments. The experimental results showed that modeling both the mean and variance trajectories are consistently superior to modeling only the mean trajectory. We also found that modeling both trajectories results in significant improvements over the conventional HMM.
Oxidative stress in growth hormone transgenic coho salmon with compressed lifespan – a model for addressing aging

Abstract Growth hormone (GH) transgenic fish have dramatically enhanced growth rates, increased oxygen demands and reactive oxygen species production. GH-transgenic coho salmon provide an opportunity to address effects of increased metabolism on physiological aging. The objective of this study was to compare oxidative stress in wild-type (WT) and GH-transgenic (T) coho salmon (Oncorhynchus kisutch) of different ages (1 and 2 years). Antioxidant enzyme activity, protein carbonyls (PC) and glutathione (GSH, GSSG) were measured. PC correlated to growth rates in individual fish. T fish exhibited lower antioxidant enzyme activities and GSH levels compared to the WT, while levels of PC and GSSG were higher. Age affects were observed in both WT and T fish; enzyme activities and GSH decreased while PC and GSSG increased. Our results support the metabolic rate theory of aging. This study aims to be a platform for continued studies of the theories of aging using fish as model organisms.
The Effect of Surface Topography on the Nonlinear Dynamics of Rossby Waves

Boussinesq convection in rotating systems attracts a sustained attention of the fluid dynamics community, because it has intricate non-linear dynamics (Cross & Hohenberg 1993) and plays an important role in geophysical and astrophysical applications, such as the motion of the liquid outer core of Earth, the Red Spot in Jupiter, the giant cells in the Sun etc. (Alridge et al. 1990). A fundamental distinction between the real geo- and astrophysical problems and the idealized laboratory studies is that natural systems are inhomogeneous (Alridge et al. 1990). Heterogeneities modulate the flow and influence significantly the dynamics of convective patterns (Alridge et al. 1990; Hide 1971). The effect of modulations on pattern formation and transition to turbulence in Boussinesq convection is far from being completely understood (Cross & Hohenberg 1993; Aranson & Kramer 2002). It is generally accepted that in the liquid outer core of the Earth the transport of the angular momentum and internal heat occurs via thermal Rossby waves (Zhang et al. 2001; Kuang & Bloxham 1999). These waves been visualized in laboratory experiments in rotating liquid-filled spheres and concentric spherical shells (Zhang et al. 2001; Kuang & Bloxham 1999). The basic dynamical features of Rossby waves have been reproduced in a cylindrical annulus, a system much simpler than the spherical ones (Busse & Or 1986; Or & Busse 1987). For convection in a cylindrical annulus, the fluid motion is two-dimensional, and gravity is replaced by a centrifugal force, (Busse & Or 1986; Or & Busse 1987). Hide (1971) has suggested that the momentum and heat transport in the core might be influenced significantly by so-called bumps, which are heterogeneities on the mantle-core boundary. To model the effect of surface topography on the transport of momentum and energy in the liquid outer core of the Earth, Bell & Soward (1996), Herrmann & Busse (1998) and Westerburg & Busse (2001) have studied the nonlinear dynamics of thermal Rossby waves in a cylindrical annulus with azimuthally modulated height.