Miracle-dz/UniFAR-FTUs huggingface dataset:
Revisiting Security Risks of Asymmetric Scalar Product Preserving Encryption and Its Variants

Cloud computing has emerged as a compelling vision for managing data and delivering query answering capability over the internet. This new way of computing also poses a real risk of disclosing confidential information to the cloud. Searchable encryption addresses this issue by allowing the cloud to compute the answer to a query based on the cipher texts of data and queries. Thanks to its inner product preservation property, the asymmetric scalar-product-preserving encryption (ASPE) has been adopted and enhanced in a growing number of works toperform a variety of queries and tasks in the cloud computingsetting. However, the security property of ASPE and its enhancedschemes has not been studied carefully. In this paper, we show acomplete disclosure of ASPE and several previously unknownsecurity risks of its enhanced schemes. Meanwhile, efficientalgorithms are proposed to learn the plaintext of data and queriesencrypted by these schemes with little or no knowledge beyondthe ciphertexts. We demonstrate these risks on real data sets.
Oral and Maxillofacial Tumours in Children and Adolescents: Clinicopathologic Audit of 75 Cases in an Academic Medical Centre, Sokoto, Northwest Nigeria

Background: Maxillofacial tumours in children and adolescents have been documented worldwide; however, few studies were reported from Africa, especially sub-Saharan Africa. In Nigeria, most of the studies emanated from the Southwest region. Aim: To present an audit of clinicopathologic features and treatment of orofacial tumours in children and adolescents in Sokoto, Northwest Nigeria. Patients and Methods: Clinicopathologic records of the Departments of Dental and Maxillofacial Surgery, Paediatrics and Histopathology, Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria, were reviewed for all the oral and maxillofacial tumours managed in children <19 years from January 2011 to December 2015. Results: Two hundred and twenty-two tumours were noted in all age groups during the study duration and 75 (33.8%) of these occurred in children and adolescents. A total of 45 (60%) males and thirty (40%) females constitute the patient population with a male to female ratio of 1.5:1. There are 32 (42.7%) benign tumours and 43 (57.3%) malignant tumours. Burkitt's lymphoma was the most common malignant tumour in 24 cases (55.8%), whereas pleomorphic adenoma was the most common benign soft tissue tumour in 4 cases (30.8%) and fibro-osseous lesions were the most common benign jaw tumours in 10 cases (52.6%). Chemotherapy alone was the treatment modality in 24 cases of malignant tumour whereas 13 cases had combination chemotherapy and irradiation. Conclusions: Our findings established that oral and maxillofacial tumours in children and adolescents are quite common in Sokoto, Northwest region of Nigeria, particularly the malignant types. There is a need for improved universal healthcare insurance for all citizens to adequately manage these children effectively.
Cross-correlation between the controlled collision environment and real-world motor vehicle collisions: Evaluating the protection of the thoracic side airbag

ABSTRACT Objective: Thoracic side airbags (tSABs) were integrated into the vehicle fleet to attenuate and distribute forces on the occupant's chest and abdomen, dissipate the impact energy, and move the occupant away from the intruding structure, all of which reduce the risk of injury. This research piece investigates and evaluates the safety performance of the airbag unit by cross-correlating data from a controlled collision environment with field data. Method: We focus exclusively on vehicle–vehicle lateral impacts from the NHTSA's Vehicle Crash Test Database and NASS-CDS database, which are replicated in the controlled environment by the (crabbed) barrier impact. Similar collisions with and without seat-embedded tSABs are matched to each other and the injury risks are compared. Results: Results indicated that dummy-based thoracic injury metrics were significantly lower with tSAB exposure (P <.001). Yet, when the controlled collision environment data were cross-correlated with NASS-CDS collisions, deployment of the tSAB indicated no association with thoracic injury (tho. MAIS 2+ unadjusted relative risk [RR] = 1.14; 90% confidence interval [CI], 0.80–1.62; tho. MAIS 3+ unadjusted RR = 1.12; 90% CI, 0.76–1.65). Conclusion: The data from the controlled collision environment indicated an unequivocal benefit provided by the thoracic side airbag for the crash dummy; however, the real-world collisions demonstrate that no benefit is provided to the occupant. This has resulted from a noncorrelation between the crash test/dummy-based design taking the abstracting process too far to represent the real-world collision scenario.
Fragment‐based approach to calculate hydrophobicity of anionic and nonionic surfactants derived from chromatographic retention on a C18 stationary phase

To predict the fate and potential effects of organic contaminants, information about their hydrophobicity is required. However, common parameters to describe the hydrophobicity of organic compounds (e.g., octanol–water partition constant [KOW]) proved to be inadequate for ionic and nonionic surfactants because of their surface‐active properties. As an alternative approach to determine their hydrophobicity, the aim of the present study was therefore to measure the retention of a wide range of surfactants on a C18 stationary phase. Capacity factors in pure water (k′0) increased linearly with increasing number of carbon atoms in the surfactant structure. Fragment contribution values were determined for each structural unit with multilinear regression, and the results were consistent with the expected influence of these fragments on the hydrophobicity of surfactants. Capacity factors of reference compounds and log KOW values from the literature were used to estimate log KOW values for surfactants (log KOWHPLC ). These log KOWHPLC values were also compared to log KOW values calculated with 4 computational programs: KOWWIN, Marvin calculator, SPARC, and COSMOThermX. In conclusion, capacity factors from a C18 stationary phase are found to better reflect hydrophobicity of surfactants than their KOW values. Environ Toxicol Chem 2017;36:329–336. © 2016 The Authors. Environmental Toxicology and Chemistry Published by Wiley Periodicals, Inc. on behalf of SETAC.
Reducing sedentary behaviour to decrease chronic low back pain: the stand back randomised trial

Objective The Stand Back study evaluated the feasibility and effects of a multicomponent intervention targeting reduced prolonged sitting and pain self-management in desk workers with chronic low back pain (LBP). Methods This randomised controlled trial recruited 27 individuals with chronic LBP, Oswestry Disability Index (ODI) >10% and desk jobs (sitting ≥20 hours/week). Participants were randomised within strata of ODI (>10%–<20%, ≥20%) to receive bimonthly behavioural counselling (in-person and telephone), a sit-stand desk attachment, a wrist-worn activity-prompting device and cognitive behavioural therapy for LBP self-management or control. Self-reported work sitting time, visual analogue scales (VAS) for LBP and the ODI were assessed by monthly, online questionnaires and compared across intervention groups using linear mixed models. Results Baseline mean (SD) age was 52 (11) years, 78% were women, and ODI was 24.1 (10.5)%. Across the 6-month follow-up in models adjusted for baseline value, work sitting time was 1.5 hour/day (P<0.001) lower comparing intervention to controls. Also across follow-up, ODI was on average 8 points lower in intervention versus control (P=0.001). At 6 months, the relative decrease in ODI from baseline was 50% in intervention and 14% in control (P=0.042). LBP from VAS was not significantly reduced in intervention versus control, though small-to-moderate effect sizes favouring the intervention were observed (Cohen’s d ranged from 0.22 to 0.42). Conclusion An intervention coupling behavioural counselling targeting reduced sedentary behaviour and pain self-management is a translatable treatment strategy that shows promise for treating chronic LBP in desk-bound employees. Trial registration number NCT0224687; Pre-results.
Quality improvement in neurology: Child neurology quality measure set

Childhood neurologic disorders, as a group, include relatively common conditions such as migraine (prevalence between 3% and 10.6% in children 3–15 years of age1,2), transient tic disorders (TDs) (3%),3 and specifically Tourette syndrome (TS) (0.8%),3 and rarer disorders such as infantile spasms that may occur in only about 1,200 infants each year in the United States. These disorders account for a disproportionately higher number of emergency department visits, intensive care admissions, deaths, and higher costs when compared to other childhood illness.4 Generally, delivery of quality care should improve outcomes and result in decreased unnecessary utilization of health services.4
Visual experience sculpts whole-cortex spontaneous infraslow activity patterns through an Arc-dependent mechanism

Significance Visual critical periods are essential for shaping the normal mature responsiveness of visual cortex neurons; however, it is unclear whether early visual experience influences functional network organization. Here we demonstrate that monocular and binocular visual deprivation (MD and BD) have distinct effects on cortical functional connectivity (FC). MD induces FC changes restricted to the visual system, while BD results in widespread FC changes between disparate brain regions. These results suggest that early exposure to altered vision (MD) induces intranetwork change, but absent vision (BD) drives internetwork change, reminiscent of cross-modal plasticity. Moreover, this early experience-driven FC change was attenuated by deletion of Arc, a gene critical for synaptic plasticity, suggesting that network relationships are modulated by changes in synaptic strengths. Decades of work in experimental animals has established the importance of visual experience during critical periods for the development of normal sensory-evoked responses in the visual cortex. However, much less is known concerning the impact of early visual experience on the systems-level organization of spontaneous activity. Human resting-state fMRI has revealed that infraslow fluctuations in spontaneous activity are organized into stereotyped spatiotemporal patterns across the entire brain. Furthermore, the organization of spontaneous infraslow activity (ISA) is plastic in that it can be modulated by learning and experience, suggesting heightened sensitivity to change during critical periods. Here we used wide-field optical intrinsic signal imaging in mice to examine whole-cortex spontaneous ISA patterns. Using monocular or binocular visual deprivation, we examined the effects of critical period visual experience on the development of ISA correlation and latency patterns within and across cortical resting-state networks. Visual modification with monocular lid suturing reduced correlation between left and right cortices (homotopic correlation) within the visual network, but had little effect on internetwork correlation. In contrast, visual deprivation with binocular lid suturing resulted in increased visual homotopic correlation and increased anti-correlation between the visual network and several extravisual networks, suggesting cross-modal plasticity. These network-level changes were markedly attenuated in mice with genetic deletion of Arc, a gene known to be critical for activity-dependent synaptic plasticity. Taken together, our results suggest that critical period visual experience induces global changes in spontaneous ISA relationships, both within the visual network and across networks, through an Arc-dependent mechanism.
Deep Scalogram Representations for Acoustic Scene Classification

Spectrogram representations of acoustic scenes have achieved competitive performance for acoustic scene classification. Yet, the spectrogram alone does not take into account a substantial amount of time-frequency information. In this study, we present an approach for exploring the benefits of deep scalogram representations, extracted in segments from an audio stream. The approach presented firstly transforms the segmented acoustic scenes into bump and morse scalograms, as well as spectrograms; secondly, the spectrograms or scalograms are sent into pre-trained convolutional neural networks; thirdly, the features extracted from a subsequent fully connected layer are fed into U+0028 bidirectional U+0029 gated recurrent neural networks, which are followed by a single highway layer and a softmax layer; finally, predictions from these three systems are fused by a margin sampling value strategy. We then evaluate the proposed approach using the acoustic scene classification data set of 2017 IEEE AASP Challenge on Detection and Classification of Acoustic Scenes and Events U+0028 DCASE U+0029. On the evaluation set, an accuracy of 64.0 U+0025 from bidirectional gated recurrent neural networks is obtained when fusing the spectrogram and the bump scalogram, which is an improvement on the 61.0 U+0025 baseline result provided by the DCASE 2017 organisers. This result shows that extracted bump scalograms are capable of improving the classification accuracy, when fusing with a spectrogram-based system.
Short-Term Peripheral Vasoactive Infusions in Pediatrics: Where Is the Harm?

Objective: Pediatric shock represents a major cause of morbidity and mortality in the United States. Standardization of treatment such as volume resuscitation and vasoactive administration has resulted in improved patient outcomes. Vasoactives have been anecdotally associated with peripheral IV infiltration and extravasation. There is a paucity of evidence in pediatrics to determine the ideal route of vasoactive infusions and what, if any, risk factors and harm are associated with peripheral IV infiltration and extravasation. We aim to assess the frequency of and risk factors for peripheral IV infiltration and extravasation during peripheral IV vasoactive infusions in children admitted to the PICU. Design: A retrospective, cohort study of all children admitted to a PICU from January 2012 to June 2014. Setting: Forty-four–bed PICU at Children’s National Health System. Patients: All children 0–18 years old receiving a vasoactive infusion through a peripheral IV for a minimum of 1 hour. Interventions: None. Measurements and Main Results: The primary outcomes of this study were incidence of peripheral IV infiltration and extravasation and resultant tissue injury. Secondary outcomes were peripheral IV characteristics and vasoactive infusion data. One hundred two patients met inclusion criteria. Sixty-two percent (63/102) were admitted with the diagnosis of septic shock. The most commonly used vasoactive agent was dopamine. The median peak Vasoactive Infusion Score was 10 (6–14). Peripheral IV infiltration and extravasation incidence was 2% (2/102) and neither event resulted in injury requiring medical or surgical intervention. Conclusions: Vasoactive infusions through peripheral IV in children admitted to the PICU with shock were observed to have a low incidence of peripheral IV infiltration and extravasation and resultant tissue injury. Short-term delivery of vasoactives via peripheral IV catheter in a highly monitored PICU setting appears to be safe.
Outpatient Percutaneous Nephrolithotomy: The UC San Diego Health Experience.

INTRODUCTION Outpatient percutaneous nephrolithotomy (PCNL) has been described for highly selected patients. We sought to assess the safety and feasibility of outpatient PCNL in a tertiary referral stone center without strict patient selection criteria. MATERIALS AND METHODS We reviewed all PCNLs performed at our institution from September 2015 to October 2016. Of the 97 eligible cases, 60 patients underwent planned outpatient PCNL. Primary outcome was complication rate, and secondary outcome determined predictor variables of inpatient admission. RESULTS Thirty-seven inpatient and 60 planned outpatient (one bilateral) PCNLs were performed with 65% and 44% American Society of Anesthesiologists (ASA) score ≥3, respectively. The 30-day overall complication rate for the inpatient and planned outpatient groups was 27% and 20%, respectively (p = 0.43) [70% and 92% Clavien grades I-II]. Emergency department presentation within 30 days was 19% and 18% (p = 0.94), and unplanned hospital readmission rate was 3% and 10% (p = 0.05). The 37 inpatient PCNL patients had larger total stone burden than outpatient cases (40.7 vs 25.8 mm, p = 0.0014); more often required two or more punctures into the kidney during the procedure (73% vs 45%, p = 0.025); and more often had supracostal access (20% vs 7%, p = 0.05). For the outpatient PCNL cohort, 72% patients were discharged same day, 28% were observed overnight for refractory symptoms or social reasons. Outpatient cohort radiographic stone-free rate by CT (no stones) was 67%. CONCLUSION Outpatient PCNL has been safely and effectively performed within our institution in moderate-sized stones almost regardless of comorbidity status. We suggest that this approach is a potential algorithmic change in centers with sufficient case volume.
Crystal Structure of the Pseudomonas aeruginosa BEL-1 Extended-Spectrum β-Lactamase and Its Complexes with Moxalactam and Imipenem

ABSTRACT BEL-1 is an acquired class A extended-spectrum β-lactamase (ESBL) found in Pseudomonas aeruginosa clinical isolates from Belgium which is divergent from other ESBLs (maximum identity of 54% with GES-type enzymes). This enzyme is efficiently inhibited by clavulanate, imipenem, and moxalactam. Crystals of BEL-1 were obtained at pH 5.6, and the structure of native BEL-1 was determined from orthorhombic and monoclinic crystal forms at 1.60-Å and 1.48-Å resolution, respectively. By soaking native BEL-1 crystals, complexes with imipenem (monoclinic form, 1.79-Å resolution) and moxalactam (orthorhombic form, 1.85-Å resolution) were also obtained. In the acyl-enzyme complexes, imipenem and moxalactam differ by the position of the α-substituent and of the carbonyl oxygen (in or out of the oxyanion hole). More surprisingly, the Ω-loop, which includes the catalytically relevant residue Glu166, was found in different conformations in the various subunits, resulting in the Glu166 side chain being rotated out of the active site or even in displacement of its Cα atom up to approximately 10 Å. A BEL-1 variant showing the single Leu162Phe substitution (BEL-2) confers a higher level of resistance to CAZ, CTX, and FEP and shows significantly lower Km values than BEL-1, especially with oxyiminocephalosporins. BEL-1 Leu162 is located at the beginning of the Ω-loop and is surrounded by Phe72, Leu139, and Leu148 (contact distances, 3.5 to 3.9 Å). This small hydrophobic cavity could not reasonably accommodate the bulkier Phe162 found in BEL-2 without altering neighboring residues or the Ω-loop itself, thus likely causing an important alteration of the enzyme kinetic properties.
Compact and Broadband RF Rectifier With 1.5 Octave Bandwidth Based on a Simple Pair of L-Section Matching Network

This letter proposes a novel wideband rectifier circuit for RF energy harvesting. The proposed circuit can collect signals efficiently over broad bandwidth spanning from 0.87 to 2.7 GHz which includes UHF ISM 900 MHz, GSM 900 and 1800 MHz, wireless communication, PCS, and ISM 2.4 GHz. In order to obtain sufficiently large rectifier bandwidth, a matching circuit based on high-pass type L-section for lower band impedance matching and inductive L-section for higher band impedance matching is proposed. The rectifier circuit is constructed using voltage doubler configuration with Schottky diode SMS7630-005LF. The circuit is optimized and refabricated to compensate the undesired parasitic and obtain the required rectifier performance. Two prototypes were simulated, fabricated, and characterized. The rectifier has a measured conversion efficiency exceeding 30% from 870 MHz to 2.5 GHz at 0 dBm input power and a load terminal of 2 $\text{k}\Omega $ and a dc output voltage equal to 1 V. The circuit sensitivity may reach up to −20 dBm with dc output voltage 40 mV and 8% conversion efficiency. The maximum measured efficiency is 63% from 1.1 to 1.35 GHz.
Effects of aging and depression on mnemonic discrimination ability

ABSTRACT Aging and depression have been found to be associated with poorer performance in mnemonic discrimination. In the current study, a two-response format mnemonic similarity test, Cognitive Drug Research MST, was used to compare these effects. Seventy-six participants were tested; with 52 participants in the young group, aged 18–35 years, and 24 participants in the elderly group, aged 55 years or older. Twenty-two young participants and 10 elderly participants met DSM-IV criteria for MDD or dysthymia. Age-related deficits were found for lure identification and speed of response. Differences in speed of responses to lure images were found for younger depressed participants, and depressive symptom severity was found to be negatively associated with lure identification accuracy in the elderly. These findings may be viewed as putative behavioral correlates of decreased pattern separation ability, which may be indicative of altered hippocampal neurogenesis in aging and depression.
Measurement of thermal properties at elevated temperatures - Brandforsk project 328-031

An investigation of the TPS (Transient Plane Source) method to determine the thermal properties for building materials at high temperature has been performed. The thermal conductivity, diffusivity and the volumetric specific heat for different building materials at room temperature and at elevated temperatures has been determined. Also influence of moisture content on the thermal properties of a number of materials was instigated.
A Mouse Model of Enterovirus D68 Infection for Assessment of the Efficacy of Inactivated Vaccine

In recent years, enterovirus D68 (EVD68) has been reported increasingly to be associated with severe respiratory tract infections and acute flaccid myelitis (AFM) in children all over the world. Yet, no effective vaccines or antiviral drugs are currently available for EVD68. Although several experimental animal models have been developed, immunogenicity and protective efficacy of inactivated EVD68 vaccines has not been fully evaluated. To promote the development of vaccines, we established an Institute of Cancer Research (ICR) suckling mouse model of EVD68 infection in this study. The results showed that ICR neonatal mice up to about nine days of age were susceptible to infection with EVD68 clinical strain US/MO/14-18947 by intraperitoneal injection. The infected mice exhibited progressive limb paralysis prior to death and the mortality of mice was age- and virus dose-dependent. Tissue viral load analysis showed that limb muscle and spinal cord were the major sites of viral replication. Moreover, histopathologic examination revealed the severe necrosis of the limb and juxtaspinal muscles, suggesting that US/MO/14-18947 has a strong tropism toward muscle tissues. Additionally, β-propiolactone-inactivated EVD68 vaccine showed high purity and quality and induced robust EVD68-specific neutralizing antibody responses in adult mice. Importantly, results from both antisera transfer and maternal immunization experiments clearly showed that inactivated EVD68 vaccine was able to protect against lethal viral infection in the mouse model. In short, these results demonstrate the successful establishment of the mouse model of EVD68 infection for evaluating candidate vaccines against EVD68 and also provide important information for the development of inactivated virus-based EVD68 vaccines.