Miracle-dz/UniFAR-FTUs huggingface dataset:
Role of Vocal Labeling in Memory for Object Arrangements by Deaf and Hearing Children

To determine the effects of vocal labels in memory using an object arrangement task 60 deaf and 30 hearing Ss were divided into two MA levels, primary and intermediate. Within each level, Ss were assigned to treatment, defined as employing vocal labels. Six groups of 15 Ss each were formed. When the groups were viewed by level, there were significant differences between primary and intermediate Ss. Vocal labels, with some notable exceptions, had little or no facilitating effects on performance of object recall. The results suggested that the availability of additional modes of mediation accounted for differences between the primary and intermediate levels. Data from the object-arrangement task provided implications for further study of conceptual behavior of deaf children.
DNA Computing by Self-Assembly

Information and algorithms appear to be central to biological organization and processes, from the storage and reproduction of genetic information to the control of developmental processes to the sophisticated computations performed by the nervous system. Much as human technology uses electronic microprocessors to control electromechanical devices, biological organisms use biochemical circuits to control molecular and chemical events. The engineering and programming of biochemical circuits, in vivo and in vitro, would transform industries that use chemical and nanostructured materials. Although the construction of biochemical circuits has been explored theoretically since the birth of molecular biology, our practical experience with the capabilities and possible programming of biochemical algorithms is still very young.
Predicting the Composition of Red Wine Blends Using an Array of Multicomponent Peptide-Based Sensors

Differential sensing using synthetic receptors as mimics of the mammalian senses of taste and smell is a powerful approach for the analysis of complex mixtures. Herein, we report on the effectiveness of a cross-reactive, supramolecular, peptide-based sensing array in differentiating and predicting the composition of red wine blends. Fifteen blends of Cabernet Sauvignon, Merlot and Cabernet Franc, in addition to the mono varietals, were used in this investigation. Linear Discriminant Analysis (LDA) showed a clear differentiation of blends based on tannin concentration and composition where certain mono varietals like Cabernet Sauvignon seemed to contribute less to the overall characteristics of the blend. Partial Least Squares (PLS) Regression and cross validation were used to build a predictive model for the responses of the receptors to eleven binary blends and the three mono varietals. The optimized model was later used to predict the percentage of each mono varietal in an independent test set composted of four tri-blends with a 15% average error. A partial least square regression model using the mouth-feel and taste descriptive sensory attributes of the wine blends revealed a strong correlation of the receptors to perceived astringency, which is indicative of selective binding to polyphenols in wine.
The diagnosis and treatment of pigmented villonodular synovitis.

1. The literature on pigmented villonodular synovitis has been reviewed and a series of eighty additional cases is reported. 2. The condition usually presents either as a nodule in a finger or knee, or as a diffuse lesion in a knee. The lesions, although benign, sometimes erode or invade the tissue of adjacent bones. 3. Distinction from malignant synovioma can be made on the basis of the macroscopic appearance of the lesion at operation (relationship to joints or tendon sheaths: villonodular appearance: pigmentation), and by histological examination. 4. Treatment of the nodular form by excision is satisfactory but extensive synovectomy for diffuse lesions of the knee gives poor results. 5. The etiology of pigmented villonodular synovitis is unknown, but it appears to be a self-limiting process, possibly inflammatory in nature.
Linear-Quadratic Control of Backward Stochastic Differential Equations

This paper is concerned with optimal control of linear backward stochastic differential equations (BSDEs) with a quadratic cost criteria, or backward linear-quadratic (BLQ) control. The solution of this problem is obtained completely and explicitly by using an approach which is based primarily on the completion-of-squares technique. Two alternative, though equivalent, expressions for the optimal control are obtained. The first of these involves a pair of Riccati-type equations, an uncontrolled BSDE, and an uncontrolled forward stochastic differential equation (SDE), while the second is in terms of a Hamiltonian system. Contrary to the deterministic or stochastic forward case, the optimal control is no longer a feedback of the current state; rather, it is a feedback of the entire history of the state. A key step in our derivation is a proof of global solvability of the aforementioned Riccati equations. Although of independent interest, this issue has particular relevance to the BLQ problem since these Riccati equations play a central role in our solution. Last but not least, it is demonstrated that the optimal control obtained coincides with the solution of a certain forward linear-quadratic (LQ) problem. This, in turn, reveals the origin of the Riccati equations introduced.
Probabilistic Shared Cache Management (PriSM)

Effective sharing of the last level cache has a significant influence on the overall performance of a multicore system. We observe that existing solutions control cache occupancy at a coarser granularity, do not scale well to large core counts and in some cases lack the flexibility to support a variety of performance goals. In this paper, we propose Probabilistic Shared Cache Management (PriSM), a framework to manage the cache occupancy of different cores at cache block granularity by controlling their eviction probabilities. The proposed framework requires only simple hardware changes to implement, can scale to larger core count and is flexible enough to support a variety of performance goals. We demonstrate the flexibility of PriSM, by computing the eviction probabilities needed to achieve goals like hit-maximization, fairness and QOS. PriSM-HitMax improves performance by 18.7% over LRU and 11.8% over previously proposed schemes in a sixteen core machine. PriSM-Fairness improves fairness over existing solutions by 23.3% along with a performance improvement of 19.0%. PriSM-QOS successfully achieves the desired QOS targets.
DiskAccel

Disk traces are typically used to analyze real-life workloads and for replay-based evaluations. This approach benefits from capturing important details such as varying behavior patterns, bursty activity, and diurnal patterns of system activity, which are often missing from the behavior of workload synthesis tools. However, accurate capture of such details requires recording traces containing long durations of system activity, which are difficult to use for replay-based evaluation. One way of solving the problem of long storage trace duration is the use of disk simulators. While publicly available disk simulators can greatly accelerate experiments, they have not kept up with technological innovations in the field. The variety, complexity, and opaque nature of storage hardware make it very difficult to implement accurate simulators. The alternative, replaying the whole traces on real hardware, suffers from either long run-time or required manual reduction of experimental time, potentially at the cost of reduced accuracy. On the other hand, burstiness, auto-correlation, and complex spatio-temporal properties of storage workloads make the known methods of sampling workload traces less effective. In this paper, we present a methodology called DiskAccel to efficiently select key intervals of a trace as representatives and to replay them to estimate the response time of the whole workload. Our methodology extracts a variety of spatial and temporal features from each interval and uses efficient data mining techniques to select the representative intervals. To verify the proposed methodology, we have implemented a tool capable of running whole traces or selective intervals on real hardware, warming up hardware state in an accelerated manner, and emulating request causality while minimizing request inter-arrival time error. Based on our experiments, DiskAccel manages to speed up disk replay by more than two orders of magnitude, while keeping average estimation error at 7.6%.
On the Gaussian Interference Channel with Half-Duplex Causal Cognition

This paper studies the two-user Gaussian interference channel with half-duplex causal cognition. This channel model consists of two source-destination pairs sharing a common wireless channel. One of the sources, referred to as the cognitive, overhears the other source, referred to as the primary, through a noisy link and can therefore assist in sending the primary's data. Due to practical constraints, the cognitive source is assumed to work in half-duplex mode, that is, it cannot simultaneously transmit and receive. This model is more relevant for practical cognitive radio systems than the classical information theoretic cognitive channel model, where the cognitive source is assumed to have a non-causal knowledge of the primary's message. Different network topologies are considered, corresponding to different interference scenarios: (i) the interference-symmetric scenario, where both destinations are in the coverage area of the two sources and hence experience interference, and (ii) the interference-asymmetric scenario, where one destination does not suffer from interference. For each topology the sum-rate performance is studied by first deriving the generalized Degrees of Freedom (gDoF), or "sum-capacity pre-log" in the high-SNR regime, and then showing relatively simple coding schemes that achieve a sum-rate upper bound to within a constant number of bits for any SNR. Finally, the gDoF of the channel is compared to that of the non-cooperative interference channel and to that of the non-causal cognitive channel to identify the parameter regimes where half-duplex causal cognition is useless in practice or attains its ideal ultimate limit, respectively.
Inhibition of Human Cytochrome P450 Enzymes 3A4 and 2D6 by β‐Carboline Alkaloids, Harmine Derivatives

β‐Carboline alkaloids are the main chemical constituents of the plant Peganum harmala, while they also could be formed endogenously and found in coffee, alcoholic beverages and tobacco. Considering the fact that the possibility of herb–drug interactions has recently received great attention worldwide, the aim of the current study was to assess the potential for the metabolism‐based drug–drug interactions arising from five β‐carboline alkaloids (harmine, harmaline, harmalol, harmol and harmane) from P. harmala in vitro. With microsome incubation assays and UPLC/HPLC methods, the inhibitions on human liver CYP3A4 and CYP2D6 enzymes by those β‐carboline alkaloids were studied kinetically. Harmine, harmol and harmane exhibited noncompetitive inhibition on the activity of CYP3A4 with Ki values of 16.76, 5.13 and 1.66 μm, respectively. These β‐carboline alkaloids were also found to be both substrates and inhibitors for CYP2D6. Harmaline, harmine and harmol showed typical competitive inhibition on the activity of CYP2D6 with Ki values of 20.69, 36.48 and 47.11 μm, respectively. The inhibition of the two major CYP enzymes by those β‐carboline alkaloids suggested that changes in the pharmacokinetics of co‐administered drugs were likely to have occurred. Therefore, caution should be exercised for possible drug interactions of medicinal plants containing those β‐carboline alkaloids and CYP substrates. Copyright © 2011 John Wiley & Sons, Ltd.
Linear-Elastic and Elastoplastic Mode II and III Crack Tip Stress-Strain Fields in Cylindrical Specimens with Circumferential Crack

A numerical analysis by means of the ANSYS code was performed in order to identify the ratio of both stress intensity factors and crack tip opening displacements for a cylindrical specimen with circumferential V-notch loaded by remote pure shear stress. This kind of loading produces pure mode II and III loading in four points on the circumferential crack front while the mix mode II+III exists in all other crack front points. In the linear-elastic range, the ratio of maximum values of mode III and mode II stress intensity factors was found to be . On the other hand, the ratio of crack tip opening displacements in the elastoplastic range approaches . These results can be used for the construction of fatigue crack growth rate curves in austenitic and ferritic steels measured in the near-threshold and near-fracture regions by means of a special testing device.
Child health service's response to early feeding and behaviour problems: changes in parental perceptions 1970–93

Objective: This health systems study was done to measure changes over time concerning parents' perceptions of feeding and behavioural problems in children 6–18 mo of age, parents' willingness to use child health services and their evaluation of the advice received. Method: The study had a repetitive cross‐sectional design. Three largely identical surveys were performed in 1970, 1988 and 1993. Questionnaires were sent to a random sample of all parents of children 6‐18 mo living in Uppsala, Sweden. Results and conclusions: The frequency of different perceived feeding and/or behavioural problems was stable or declined between 1970 and 1988, but increased in 1993. For most problems, inclination to seek help and perceived benefit of advice decreased between 1970 and 1988, but increased again in 1993. The parents sought more help and perceived the advice they received as more beneficial when the service was in the hands of paediatric nurses (1970) or of district nurses focusing on the care of infants and preschool children (1993) than when the district nurses also had responsibilities for adults and the elderly (1988). No correlation was seen with societal and sociodemographic trends. Although the cross‐sectional (hence non‐experimental) design of the study makes it impossible to prove causality, the findings suggest that parents' willingness to use the child health service and their evaluation of that service may depend in part on organization, including the degree to which nurses with “first‐line” contacts are focused on paediatric services.
Audio representations of multi-channel EEG: a new tool for diagnosis of brain disorders.

OBJECTIVE The objective of this paper is to develop audio representations of electroencephalographic (EEG) multichannel signals, useful for medical practitioners and neuroscientists. The fundamental question explored in this paper is whether clinically valuable information contained in the EEG, not available from the conventional graphical EEG representation, might become apparent through audio representations. METHODS AND MATERIALS Music scores are generated from sparse time-frequency maps of EEG signals. Specifically, EEG signals of patients with mild cognitive impairment (MCI) and (healthy) control subjects are considered. Statistical differences in the audio representations of MCI patients and control subjects are assessed through mathematical complexity indexes as well as a perception test; in the latter, participants try to distinguish between audio sequences from MCI patients and control subjects. RESULTS Several characteristics of the audio sequences, including sample entropy, number of notes, and synchrony, are significantly different in MCI patients and control subjects (Mann-Whitney p < 0.01). Moreover, the participants of the perception test were able to accurately classify the audio sequences (89% correctly classified). CONCLUSIONS The proposed audio representation of multi-channel EEG signals helps to understand the complex structure of EEG. Promising results were obtained on a clinical EEG data set.
Piezoelectric and Dielectric Properties of Ceramics in the System Potassium—Sodium Niobate

High radial coupling coefficients are observed for compositions having up to 50 mole % sodium niobate additions to potassium niobate. The activity diminishes with additional sodium niobate content and disappears beyond about 98 mole % additions. Dielectric constants are relatively low, varying from 450 to 125, depending on composition. A. -c. losses are high and d. -c. resistivities are ∼1012ohm-cm. The low dielectric constants and high coupling obtained in certain regions of the system make these materials promising for solid ultrasonic delay line use, especially where thin sectioned plates are required, as in high-frequency thickness extensional or thickness shear mode transducers.
Universal authentication protocols for anonymous wireless communications

A secure roaming protocol allows a roaming user U to visit a foreign server V and establish a session key in an authenticated way such that U authenticates V and at the same time convinces V that it is a legitimate subscriber of some server H, called the home server of U. The conventional approach requires the involvement of all the three parties. In this paper, we propose a new approach which requires only two parties, U and V, to get involved. We propose two protocols: one provides better efficiency and supports user anonymity to an extent comparable to that provided by current mobile systems; and the other one achieves strong user anonymity that protects U's identity against both eavesdroppers and foreign servers and is currently the strongest notion of user anonymity defined for secure roaming. Both protocols are universal in the sense that the same protocol and signaling flows are used regardless of the domain (home or foreign) that U is visiting. This helps reducing the system complexity in practice. We also propose a practical user revocation mechanism, which is one of the most challenging problems for two-party roaming supporting strong user anonymity. Our solutions can be applied in various kinds of roaming networks such as cellular networks and interconnected wireless local area networks.
On program equivalence in languages with ground-type references

Using game semantics we prove that program equivalence is undecidable in finitary Idealized Algol with active expressions as well as in its call-by-value counterpart. It is also shown that strategies corresponding to Idealized Algol terms of respectively second, third and higher orders define exactly regular, context-free and recursively enumerable languages.
Harpagoside suppresses IL‐6 expression in primary human osteoarthritis chondrocytes

There is growing evidence in support of the involvement of inflammatory response in the pathogenesis of osteoarthritis (OA). Harpagoside, one of the bioactive components of Harpagophytum procumbens (Hp), has been shown to possess anti‐inflammatory properties. Here we used an in vitro model of inflammation in OA to investigate the potential of harpagoside to suppress the production of inflammatory cytokines/chemokines such as IL‐6 and matrix degrading proteases. We further investigated the likely targets of harpagoside in primary human OA chondrocytes. OA chondrocytes were pre‐treated with harpagoside before stimulation with IL‐1β. mRNA expression profile of 92 cytokines/chemokines was determined using TaqMan Human Chemokine PCR Array. Expression levels of selected mRNAs were confirmed using TaqMan assays. Protein levels of IL‐6 and MMP‐13 were assayed by ELISA and immunoblotting. Total protein levels and phosphorylation of signaling proteins were determined by immunoblotting. Cellular localization of IL‐6 and c‐Fos was performed by immunofluorescence and confocal microscopy. DNA binding activity of c‐FOS/AP‐1 was determined by ELISA. Harpagoside significantly altered the global chemokine expression profile in IL‐1β‐stimulated OA chondrocytes. Expression of IL‐6 was highly induced by IL‐1β, which was significantly inhibited by pre‐treatment of OA chondrocytes with harpagoside. Harpagoside did not inhibit the IL‐1β‐induced activation of NF‐κB and C/EBPβ transcription factors but suppressed the IL‐1β‐triggered induction, phosphorylation, and DNA binding activity of c‐FOS, one of the main components of AP‐1 transcription factors. Further, harpagoside significantly inhibited the expression of MMP‐13 in OA chondrocytes under pathological conditions. siRNA‐mediated knockdown of IL‐6 resulted in suppressed expression and secretion of MMP‐13 directly linking the role of IL‐6 with MMP‐13 expression. Taken together, the present study suggests that harpagoside exerts a significant anti‐inflammatory effect by inhibiting the inflammatory stimuli mediated by suppressing c‐FOS/AP‐1 activity in OA chondrocytes under pathological conditions. © 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:311–320, 2017.
Human neural cell adhesion molecule L1 and rat homologue NILE are ligands for integrin alpha v beta 3

Integrin alpha v beta 3 is distinct in its capacity to recognize the sequence Arg-Gly-Asp (RGD) in many extra-cellular matrix (ECM) components. Here, we demonstrate that in addition to the recognition of ECM components, alpha v beta 3 can interact with the neural cell adhesion molecule L1-CAM; a member of the immunoglobulin superfamily (IgSF). M21 melanoma cells displayed significant Ca(++)-dependent adhesion and spreading on immunopurified rat L1 (NILE). This adhesion was found to be dependent on the expression of the alpha v-integrin subunit and could be significantly inhibited by an antibody to the alpha v beta 3 heterodimer. M21 cells also displayed some alpha v beta 3-dependent adhesion and spreading on immunopurified human L1. Ligation between this ligand and alpha v beta 3 was also observed to promote significant haptotactic cell migration. To map the site of alpha v beta 3 ligation we used recombinant L1 fragments comprising the entire extracellular domain of human L1. Significant alpha v beta 3-dependent adhesion and spreading was evident on a L1 fragment containing Ig-like domains 4, 5, and 6. Importantly, mutation of an RGD sequence present in the sixth Ig-like domain of L1 abrogated M21 cell adhesion. We conclude that alpha v beta 3-dependent recognition of human L1 is dependent on ligation of this RGD site. Despite high levels of L1 expression the M21 melanoma cells did not display significant adhesion via a homophilic L1-L1 interaction. These data suggest that M21 melanoma cells recognize and adhere to L1 through a mechanism that is primarily heterophilic and integrin dependent. Finally, we present evidence that melanoma cells can shed and deposit L1 in occluding ECM. In this regard, alpha v beta 3 may recognize L1 in a cell-cell or cell- substrate interaction.
THE VERTEBRATE EYE

I was merelyconcerned to report these cases, which I had found of interest, and to point out that though they diflered considerably in clinical appearance 'each was mnonocular, chronic in course, and revealed similar non-,specific changes on biopsy. The list of conditio'ns which Major Wright indicates may be included in Parinaud's oculoglandular syndrome lends support to his view that this syndrome is liberal in its clinical confines; it would seem that such a label can' add little information to a particular case. I took as my guide to Verhoeff's''leptothicosis conjunctivae his original paper published in 1918. As. I pointed out, the special staining for the organism waLs not carried out but the clinical course and pathological findings for my cases were so-dissimilar from the Author's description that I felt justified" in excluding this 'diagnosis. Major' Wright mentioned that the first of 'my c'ases had been previously under his care and I would like to correct any implied discourtesy in not having acknowledged this fact. Any chronic recurrent disease in a service patient tends to gravitate to a number of Army Medical Centres. It happens that the four cases under discussion were seen by one or more colleagues, to have referred to each of whom would have burdened unnecessarily a paper of small scope. Yours, etc.