Miracle-dz/UniFAR-FTUs huggingface dataset:
Immediate biopsy of cervical cytology‐negative and non‐HPV‐16/18 oncogenic types positive patients

According to the American Society of Colposcopy and Cervical Pathology (ASCCP), a co‐test is recommended for patients one year after the detection of non‐HPV 16/18 viral types in association with a negative cervical cytology. In this study, we used immediate colposcopy to evaluate the risks to the patient during the one year waiting period.
Modifying the Standard Disk Model for the Ultraviolet Spectral Analysis of Disk-dominated Cataclysmic Variables. I. The Novalikes MV Lyrae, BZ Camelopardalis, and V592 Cassiopeiae

The standard disk is often inadequate to model disk-dominated cataclysmic variables (CVs) and generates a spectrum that is bluer than the observed UV spectra. X-ray observations of these systems reveal an optically thin boundary layer (BL) expected to appear as an inner hole in the disk. Consequently, we truncate the inner disk. However, instead of removing the inner disk, we impose the no-shear boundary condition at the truncation radius, thereby lowering the disk temperature and generating a spectrum that better fits the UV data. With our modified disk, we analyze the archival UV spectra of three novalikes that cannot be fitted with standard disks. For the VY Scl systems MV Lyr and BZ Cam, we fit a hot inflated white dwarf (WD) with a cold modified disk ( a few 10−9 M⊙ yr−1). For V592 Cas, the slightly modified disk ( ) completely dominates the UV. These results are consistent with Swift X-ray observations of these systems, revealing BLs merged with ADAF-like flows and/or hot coronae, where the advection of energy is likely launching an outflow and heating the WD, thereby explaining the high WD temperature in VY Scl systems. This is further supported by the fact that the X-ray hardness ratio increases with the shallowness of the UV slope in a small CV sample we examine. Furthermore, for 105 disk-dominated systems, the International Ultraviolet Explorer spectra UV slope decreases in the same order as the ratio of the X-ray flux to optical/UV flux: from SU UMa’s, to U Gem’s, Z Cam’s, UX UMa’s, and VY Scl’s.
Cochlear implant-evoked electrical auditory brainstem responses during surgery in patients with auditory neuropathy spectrum disorder

Introduction During recent years, cochlear implantation has become an established treatment option for some patients with auditory neuropathy spectrum disorder (ANSD). In a study from Berlin et al. (2010), 85% of the patients diagnosed with ANSD had developed improved speech comprehension and language acquisition with a cochlear implant (CI). This study investigates the implant electrically evoked auditory brainstem responses (impEABR) in ANSD children. Do the impEABR results in non-ANSD children differ from children with ANSD, in terms of amplitude of eV and latency of eV ImpEABR is a known procedure for testing adults and children with a CI and in some cases it can predict speech recognition outcomes. A study from Walton et al. (2008) shows the use of impEABR measurements on a large number of patients with CI as an indicator of speech perception performance. For diagnosing ANSD an extensive measurement protocol has been developed at Oslo University Hospital. As part of the newborn screening protocol, otoacoustic emissions and automatic auditory brainstem response (AABR) measurements are obtained. All patients from the neonatal intensive care unit undergo an AABR measurement. All assessments are carried out after tympanometry and otomicroscopy. All patients with absent AABRs or those who are too old for AABRs were investigated by diagnostic auditory brainstem responses (ABR) in either awake, natural sleep, or anaesthesia conditions. For detecting cochlear microphonics (CM) the ABR method used rarefaction and condensation clicks to detect possible CMs. Then stapedius reflexes measurements were obtained. For older children or adults, audiogram or play audiometry was done as well as age appropriate speech perception tests. For young children, parents filled out a questionnaire such as LittleEARS to evaluate speech comprehension. If the child has delayed speech and language development, then a CI is considered. Magnet resonance imaging (MRI) and a computed tomogram were carried out on all children to evaluate the anatomical status of the cochlea and auditory nerve. Studies have shown (Buchman et al., 2006; Walton et al., 2008; Sharma et al., 2011) that cochlear nerve deficiency can cause poorer benefit with a CI, and therefore MRI is an essential part of diagnosing ANSD at our hospital. In some cases genetic testing is done to determine whether there may be malfunctions of the inner hair cells due to genetic mutation as described by Berlin et al. (2010). In cases of children diagnosed with ANSD, these patients will be observed and treated with hearing aids until the age of 2. A study from Raveh et al. (2007) describes spontaneous development of brainstem responses within the first year of life. This is confirmed by observation at our hospital where a newborn baby was diagnosed ANSD and developed later normal speech and language comprehension. An exception would be genetic mutations that identify inner hair cell abnormalities.
Direct Fabrication of Hierarchical Microstructures on Metals by Means of Direct Laser Interference Patterning

We have studied the fabrication of hierarchical periodic microstructures on metals by means of direct laser interference patterning. A nanosecond pulsed Nd: YAG laser at 355 nm wavelength was used to produce the microstructures with grating periods ranging from 1 μm to 10 μm on stainless steel, titanium, and aluminum. The results indicate that the geometrical characteristics of the interference patterns as well as the thermal properties of the substrates determine the quality of the fabricated structures. In particular, the best structures were obtained when the material at the interference minima position remained in the solid state and the temperature at the interference maxima is below the vaporization temperature. Thermal simulations by finite element method were carried out modeling photothermal interactions of the interference pattern with the metallic substrates to evaluate laser induced thermal effects, such as temperature distribution and temperature gradients and, thus, enabling us to explain the obtained results.
Current management strategies and long‐term clinical outcomes of upper extremity venous thrombosis

Essentials Few data exist on outcome of upper extremity deep and superficial vein thrombosis (UEDVT and UESVT). We followed 102 and 55 patients with UEDVT or UESVT, respectively, for a median of 3.5 years. Risk of recurrent venous thromboembolism was low in both diseases, and the mortality high. Postthrombotic symptoms were infrequent and cancer patients had a higher risk of recurrent VTE.
Resource Scheduling and Delay Analysis for Workflow in Wireless Small Cloud

This paper studies resource scheduling for wireless small cloud assuming that the execution of an application is modeled as a workflow graph. A scheduling method is proposed which consists of two parts. For the task-to-computing-unit assignment part which operates on the long-term time-scale, the solution is to partition the workflow into task groups which have loose data transfer constraint and each task group is assigned to the computing unit which can finish executing the task group at the earliest time. For the computing and wireless communication resource scheduling part which operates on the short-term time-scale, we simply use the round-robin principle. A part by part delay component estimation method is presented based on which the average delay performance can be analyzed. Simulation results validate the theoretical analysis and show that the proposed method outperforms existing methods. The impact of different parameter settings on the system performance is also investigated.
Depressive symptoms and all-cause mortality in people with type 2 diabetes: a focus on potential mechanisms.

BACKGROUND Depression has been associated with increased all-cause mortality in people with type 2 diabetes. AIMS To test whether anhedonia, dysphoria and anxiety are differentially associated with all-cause mortality and examine symptom-specific behavioural or pathophysiological mechanisms. METHOD A total of 1465 people completed the Edinburgh Postnatal Depression Scale in 2005 and were followed until death or 31 December 2010. Cox regression analyses compared survival time for people with a low v. high baseline dysphoria/anhedonia/anxiety score and identified mediating mechanisms. RESULTS After a mean follow-up of 1878 days (s.d. = 306), 139 participants had died. At all time points, people with anhedonia had an almost twofold increased mortality risk compared with those without anhedonia. Physical activity met criteria for mediation. Symptoms of dysphoria and anxiety were not associated with survival time. CONCLUSIONS Symptoms of anhedonia predicted shorter survival time, whereas dysphoria/anxiety did not. Mechanistic pathways, in particular physical activity, should be explored further.
Intoxications in the STRIDA project involving a panorama of psychostimulant pyrovalerone derivatives, MDPV copycats

Abstract Context: An increasing number of new psychoactive substances (NPS) of different chemical classes have become available through marketing and sale over the Internet. This report from the Swedish STRIDA project presents the prevalence, laboratory results, and clinical features in intoxications involving 11 stimulant pyrovalerone NPS derivatives over a 5-year period. Study design: Case series of consecutive patients with admitted or suspected intake of NPS presenting to Swedish hospitals for emergency treatment from January 2011 to March 2016. Patients and method: Blood and urine samples were collected from intoxicated patients presenting to hospitals all over Sweden. Analyses of NPS and other drugs of abuse were performed by immunochemical and liquid chromatography–mass spectrometry multi-component methods. Clinical data were collected during consultation with the Swedish Poisons Information Centre (PIC), and retrieved from medical records. The study involved analytically confirmed cases with 11 pyrovalerone drugs. Results: During the study period, 114 intoxications were detected that involved any of 11 new pyrovalerone drugs. In addition to these new pyrovalerone derivatives, 3,4-methylenedioxypyrovalerone (MDPV) was detected in 17 of the cases and α-pyrrolidinovalerophenone (α-PVP) in 45 cases. Identification was made according to forensic standards and comprised the following substances: 4F-α-PVP, α-PHP, PV8, 4Me-PPP, α-PBP, 4F-PV8, α-PPP, MDPHP, α-PVT, 4Cl-α-PVP, and 4F-α-PHP. The three most frequently detected drugs were α-PBP, MDPHP, and 4F-α-PVP. The age range of patients was 16–66 (median 30) years and 84% were males. The substance concentrations in urine and serum were highly variable, ranging from 1 ng/mL to 300 µg/mL. Poly-drug use was common with only 8 of 114 cases (7%) involving one pyrovalerone drug. The additional substances comprised other NPS and classical psychoactive drugs. The patients showed a variety of clinical signs; agitation, delirium, hallucinations, excessive motor activity, seizures, tachycardia, hypertension, and/or hyperthermia. Conclusions: In analytically confirmed NPS-related intoxications, 11 new pyrovalerone derivatives in addition to MDPV and α-PVP were found. The clinical features were consistent with a sympathomimetic toxidrome, but the urine and serum concentrations were highly variable. The results demonstrated that many novel pyrovalerone stimulants were introduced on the recreational NPS drugs market. Analytical investigations were necessary to obtain this information.
Vertebrate Tropomyosin as an Allergen.

Peixoto S1, Monteiro T1, Carvalho M1, Santos M2, Matos C3, Bartolomé B4, Labrador-Horrillo M5, Quaresma M1 1Pediatric Department, Centro Hospitalar de Trás-os-Montes e Alto Douro, Vila Real, Portugal 2Department of Psychiatry and Mental Health, CHTMAD, Vila Real, Portugal 3Nutrition Service of Centro Hospitalar de Trás-os-Montes e Alto Douro, Vila Real, Portugal 4Roxall, R&D Department, Bilbao, Spain 5Allergy Section, Vall d’Hebron Hospital, Barcelona, Spain
Sim1 Neurons Are Sufficient for MC4R-Mediated Sexual Function in Male Mice

Sexual dysfunction is a poorly understood condition that affects up to one-third of men around the world. Existing treatments that target the periphery do not work for all men. Previous studies have shown that central melanocortins, which are released by pro-opiomelanocortin neurons in the arcuate nucleus of the hypothalamus, can lead to male erection and increased libido. Several studies specifically implicate the melanocortin 4 receptor (MC4R) in the central control of sexual function, but the specific neural circuitry involved is unknown. We hypothesized that single-minded homolog 1 (Sim1) neurons play an important role in the melanocortin-mediated regulation of male sexual behavior. To test this hypothesis, we examined the sexual behavior of mice expressing MC4R only on Sim1-positive neurons (tbMC4Rsim1 mice) in comparison with tbMC4R null mice and wild-type controls. In tbMC4Rsim1 mice, MC4R reexpression was found in the medial amygdala and paraventricular nucleus of the hypothalamus. These mice were paired with sexually experienced females, and their sexual function and behavior was scored based on mounting, intromission, and ejaculation. tbMC4R null mice showed a longer latency to mount, a reduced intromission efficiency, and an inability to reach ejaculation. Expression of MC4R only on Sim1 neurons reversed the sexual deficits seen in tbMC4R null mice. This study implicates melanocortin signaling via the MC4R on Sim1 neurons in the central control of male sexual behavior.
Integrating GeoGebra with TPACK in Improving Pre-Service Mathematics Teachers’ Professional Development

The relationship between the use of Geogebra and Technological Pedagogical Content and Knowledge (TPACK) by teachers has not been fully investigated and understood. Therefore, the aim of this study was to integrate GeoGebra technology to develop the TPACK of secondary school pre-service mathematics teachers. The participants of this study were 60 Indian teachers. Data were collected through the administration of pre-post TPACK surveys using a Google Online survey. Results from the survey revealed that there were changes in teachers' TPACK after undergoing the Geogebra workshop. Practical implications are discussed regarding how to enhance pre-service teachers' TPACK using GeoGebra in mathematics teaching.
Isotopic niches support the resource breadth hypothesis

Because a broad spectrum of resource use allows species to persist in a wide range of habitat types, and thus permits them to occupy large geographical areas, and because broadly distributed species have access to more diverse resource bases, the resource breadth hypothesis posits that the diversity of resources used by organisms should be positively related with the extent of their geographic ranges. We investigated isotopic niche width in a small radiation of South American birds in the genus Cinclodes. We analysed feathers of 12 species of Cinclodes to test the isotopic version of the resource breadth hypothesis and to examine the correlation between isotopic niche breadth and morphology. We found a positive correlation between the widths of hydrogen and oxygen isotopic niches (which estimate breadth of elevational range) and widths of the carbon and nitrogen isotopic niches (which estimates the diversity of resources consumed, and hence of habitats used). We also found a positive correlation between broad isotopic niches and wing morphology. Our study not only supports the resource breadth hypothesis but it also highlights the usefulness of stable isotope analyses as tools in the exploration of ecological niches. It is an example of a macroecological application of stable isotopes. It also illustrates the importance of scientific collections in ecological studies.
Family Consumer Behaviors, Adolescent Prediabetes and Diabetes in the National Health and Nutrition Examination Survey (2007–2010)

ABSTRACT Background: Prediabetes or diabetes (characterized by hemoglobin A1c [HbA1c] levels ≥ 5.7 gm%) has been associated with numerous long-term complications. Family consumer behaviors are important risk factors that lead to impaired glucose tolerance or diabetes. However, few studies have studied the association between the family consumer environment and prediabetes and diabetes in adolescents. Objective: The aim of this study was to examine the association between family consumer behaviors (healthy food availability and supermarket spending) and adolescent prediabetes and diabetes (ClinicalTrials.gov identifier #NCT03136289.) Methods: Data from a nationwide survey conducted by the Centers for Disease Control and Prevention (National Health and Nutrition Examination Survey [NHANES] 2007–2010 data) were used for these analyses. Adolescents aged 12–19 years were selected for this study. Bivariate analyses and logistic regression models assessed the relationship between family consumer behaviors and the prevalence of adolescent prediabetes and diabetes. Multivariable models adjusted for age, gender, ethnicity, physical activity, education, income, and household size. Results: A total of 2520 adolescents were eligible for this study. Adolescents with healthier household food availability had negative odds (odds ratio [OR] = 0.74, 95% confidence interval [CI], 0.55–1.00), as did higher log supermarket spending (OR = 0.69; 95% CI, 0.57–0.85). Interaction models demonstrated that adolescent females had more negative odds of prediabetes/diabetes for both healthier food availability (OR = 0.79, 95% CI, 0.39–1.29) and for greater log supermarket spending (OR = 0.69, 95% CI, 0.57–0.85). Conclusion: This study shows that both healthy food availability and an increase in supermarket spending were associated with a decreased adjusted prevalence of prediabetes and diabetes in adolescents, with a greater effect in females. These results suggest the need for policy and dietary interventions targeting the consumer environment.
Sovereign Debt and Structural Reforms

Motivated the European debt crisis, we construct a tractable theory of sovereign debt and structural reforms under limited commitment. The government of a sovereign country which has fallen into a recession of an uncertain duration issues one-period debt and can renege on its obligations by suffering a stochastic default cost. When faced with a credible default threat, creditors can make a take-it-or-leave-it debt haircut offer to the sovereign. The risk of renegotiation is reflected in the price at which debt is sold. The sovereign government can also do structural policy reforms that speed up recovery from the recession. We characterize the competitive equilibrium and compare it with the constrained efficient allocation. The equilibrium features increasing debt, falling consumption, and a non-monotone reform effort during the recession. In contrast, the constrained optimum yields step-wise increasing consumption and step-wise decreasing reform effort. Markets for state-contingent debt alone do not restore efficiency. The constrained optimum can be implemented by a flexible assistance program enforced by an international institution that monitors the reform effort. The terms of the program are improved every time the country poses a credible threat to leave the program unilaterally without repaying the outstanding loans.
Palmitoylation of the P2X7 receptor, an ATP‐gated channel, controls its expression and association with lipid rafts

The P2X7 receptor (P2X7R) is an ATP‐gated cationic channel expressed by hematopoietic, epithelial, and neuronal cells. Prolonged ATP exposure leads to the formation of a nonselective pore, which can result in cell death. We show that P2X7R is associated with detergent‐resistant membranes (DRMs) in both transfected human embryonic kidney (HEK) cells and primary macrophages independently from ATP binding. The DRM association requires the posttranslational modification of P2X7R by palmitic acid. Treatment of cells with the palmitic acid analog 2‐bromopalmitate as well as mutations of cysteine to alanine residues abolished P2X7R palmitoylation. Substitution of the 17 intracellular cysteines of P2X7R revealed that 4 regions of the carboxyl terminus domain are involved in palmitoylation. Palmitoylation‐defective P2X7R mutants showed a dramatic decrease in cell surface expression because of their retention in the endoplasmic reticulum and proteolytic degradation. Taken together, our data demonstrate that P2X7R palmitoylation plays a critical role in its association with the lipid microdomains of the plasma membrane and in the regulation of its half‐life. — Gonnord, P., Delarasse, C. , Auger, R. , Benihoud, K. , Prigent, M. , Cuif, M. H. , Lamaze, C. , Kanellopoulos, J. M. Palmitoylation of the P2X7 receptor, an ATP‐gated channel, controls its expression and association with lipid rafts. FASEB J. 23, 795–805 (2009)
Adjusting to Globalization in Germany

We study the impact of trade exposure on the job biographies of 2.4 million manufacturing workers in Germany. Rising export opportunities lead to two equally important sources of earnings gains: on the job and employer switches within the same industry. Highly skilled workers benefit the most. Import shocks mostly hurt low-skilled workers, especially when they possess lots of industry-specific human capital. They also destroy workers’ rents when separating from high-wage plants, and they leave strongly scarring effects in the event of a mass layoff. We connect our results to the growing theoretical literature on the labor market effects of trade.
Development of porous silicon-based miniature fuel cells

Nowadays the rise in portable electronics requires energy sources compatible with the environmental constraints. We demonstrate, in this paper, how microfabrication techniques allow the development of low-cost miniature fuel cells fully integrated on silicon. Contrary to usual proton-conducting membranes made of ionomers ensuring the proton conductivity of proton-exchange membrane fuel cells (PEMFCs), we present here another way to proceed. It consists in the chemical grafting of molecules bearing acid groups on the pore walls of a porous silicon membrane to mimic the structure of an ionomer, such as Nafion®. We obtain an inorganic, dimensionally stable, proton-conducting membrane with many optimizable parameters such as the pore size and the pore structure of the membrane or the nature of the grafted molecules. Moreover, the use of a silicon substrate offers advantages of serial and parallel integration, the possibility of encapsulation by wafer bonding and gas feed and electrical contacts may be included into the membrane etching process, thanks to simple KOH wet etching processes and metal sputtering.
Dynamic VRPs: A Study of Scenarios

Many day-to-day routing problems are dynamic in nature: new orders are received as time progresses and must be incorporated into an evolving schedule. Taxis and parcel delivery couriers are examples. However, there is very little work available on these problems in the Operations Research literature. This paper is a look at some of the issues raised by dynamic problems. We introduce some benchmark data derived from classic VRP benchmarks, and discuss some of the complications in creating this data. We look how the cost of the system is affected by the degree of dynamicity, deﬁned here to be the proportionof the parcels which are known beforehand. We look also at the cost of maintaining a commit horizon where the schedule is ﬁxed ahead of time for communications or other business reasons.