Miracle-dz/UniFAR-FTUs huggingface dataset:
Reflexive culture in adolescents and adults with group A streptococcal pharyngitis.

BACKGROUND Guidelines currently provide conflicting recommendations regarding the diagnosis of group A streptococcal (GAS) pharyngitis in adults. Clinical guidelines state that negative rapid antigen detection tests (RADTs) do not require confirmation by a backup method in adults, whereas laboratory-based guidelines mandate confirmation of a negative RADT in patients of all ages. The objective of this study was to assess the utility of reflexive culture following a negative RADT in adolescents and adults with suspected GAS pharyngitis. METHODS A retrospective analysis of 726 patients, aged ≥13 years, with negative RADTs and positive GAS throat cultures, was performed between 1 January 2000 and 31 December 2011 at 2 academic medical centers in Seattle, Washington. Complication rates, treatment, modified Centor score, and bacterial burden in patients with negative RADTs and positive GAS throat cultures were assessed. RESULTS Modified Centor scores ≥2 were observed in 55% of patients with a negative RADT and positive GAS culture. Of these, 77% of patients had a moderate or heavy bacterial burden (≥2+). RADTs failed to detect some patients who presented with serious complications of GAS pharyngitis: 29 (4.0%) had peritonsillar abscesses and 2 (0.28%) were diagnosed with acute rheumatic fever. Providers found culture results to be useful for initiating antibiotic therapy or confirming a clinical diagnosis. Antibiotic treatment was prescribed in 68.7% of patients, with culture-directed initiation of therapy documented in 43.5%. CONCLUSIONS Reflexive GAS culture is clinically useful when RADTs are negative. RADTs fail to detect a substantial number of adult patients with clinically significant pharyngitis who can benefit from treatment.
Sparse Probabilistic Principal Component Analysis

Compositions including at least one organic ligand including a first hetero atom and a second hetero atom directly bonded to the first hetero atom or located one carbon atom away from the first hetero atom, with at least one of the hetero atoms being nitrogen, and a transition metal moiety partially complexes by the organic ligand are provided. Such complexes have a controlled adaptable proton transfer ability and/or a hydrogen bonding ability which makes such compositions particularly useful as chemical reaction facilitators. Examples of chemical reactions facilitated by such compositions include hydrolysis reactions and carbon dioxide conversion reactions.
American Serial Rape, 1940–2010

Little is known about the social correlates of serial rape or about trends in offending across time and space in the United States. Furthermore, the limited serial rape scholarship that exists was largely generalized from small, captive samples. The current study aims to amplify our understanding of serial rape by pursuing three fundamental objectives. First, guided by theory and research we propose a new, more precise, and comprehensive conceptualization of serial rape. Next, we draw from media representations of serial rape published in five major American newspapers from 1940 to 2010 to develop an offender social profile and to identify patterns in attack style. Our analysis of a broad and diverse sample of serial offenders described in media accounts (N = 1,037) produced the following profile estimates—age: 27 years; race/ethnicity: African American, 46%; Caucasian, 29%; Latino, 19%; Asian, 5%. Most offenders were employed in unskilled or semiskilled occupations and the most common attack strategy was the surprise approach (47%). Finally, our data allow us to estimate and interpret historical trends as depicted in media accounts. Our analysis revealed low levels of serial rape in newspaper accounts during the 1940s to 1950s, followed by a steady increase (with periodic decreases) leading to a peak in 1991. This peak is followed by a steady and dramatic decline from 1992 to 2010.
Anderson-Fabry disease: long-term echocardiographic follow-up under enzyme replacement therapy.

AIMS Anderson-Fabry disease affects various organ systems due to glycosphingolipid accumulation. Enzyme replacement therapy (ERT) has been reported to decrease left ventricular wall thickening (LVWT) and to improve diastolic dysfunction. METHODS AND RESULTS This prospective study included 29 patients (patients; mean age 37 +/- 13 years) with genetically, enzymatically and/or biopsy-proven Anderson-Fabry disease and long-time ERT. Data on symptoms, cardiac medications and history of hypertension were collected and all patients had comprehensive echocardiographic examination prior to ERT and at follow-up. Disease was at an early stage with a total mean Mainz severity score index of only 18.6 +/- 13.0. Prior to ERT, 79% of patients reported acroparesthesia. The median creatinine level was 121 +/- 108 mcmol/L and LVWT was present in nine patients (31%). Binary appearance of the interventricular septum was found in 20% and posterobasal fibrosis in 83%. At median follow-up of 37 months, acroparesthesia decreased to 55% (P = 0.016). There was no change in creatinine levels. The incidence of LVWT was unchanged, only an increase in interventricular septal wall thickness from 11.7 +/- 0.4 to 12.5 +/- 0.5 was observed (P = 0.009). Left atrial size and the percentage of patients with binary appearance and posterobasal fibrosis were unchanged. There was a small improvement in diastolic function (29% decrease of E/Ea; P < 0.002). CONCLUSION Our Anderson-Fabry cohort had successful long-time ERT with impressive amelioration of subjective symptoms. Although there was not much improvement in cardiac changes apart from a slight improvement of diastolic function, at least, there was no progression of cardiac disease. For complete reversibility of cardiac changes in Anderson-Fabry disease, ERT might have to be started earlier in life and/or prescribed for a longer time.
Recollective qualities modulate hippocampal activation during autobiographical memory retrieval

Recent neuroimaging studies report preferential hippocampal engagement during autobiographical memory (AM) retrieval. Although the basis of this preferential activation remains unclear, it may be related to the temporal specificity, recency, or recollective qualities of AMs, such as detail, emotionality, and personal significance. Typically, however, these variables are confounded, and thus we sought to investigate the contributions of each to hippocampal activation during AM retrieval. We conducted an event‐related functional magnetic resonance imaging (fMRI) study in which participants retrieved temporally specific AMs and general, repeated AMs, and rated each for level of detail, emotion, or personal significance. These ratings, as well as the recency of AMs, were used in parametric modulation analyses to identify brain regions that correlated positively with ratings, independent of recency, and vice versa. Retrieval of AMs activated a number of regions, including the hippocampus. No differences in hippocampal activation were evident between specific and general AM retrieval, suggesting that temporal specificity, on its own, is not a key modulator of hippocampal activation. Activation of the left hippocampus during specific AM retrieval did vary with the level of detail, personal significance, and at a subthreshold level, emotionality, when the effect of recency was covaried out. Further, during general AM retrieval, all three recollective qualities modulated activity in the right hippocampus. Although the recency of specific AMs modulated hippocampal activation bilaterally, this effect dissipated in the left hippocampus when detail or emotionality was included as a covariate, and was no longer present in either hippocampus when personal significance was taken into account. Our results suggest that recollective qualities are important predictors of hippocampal engagement during AM retrieval independent of factors such as recency. These findings are consistent with theories of hippocampal function that emphasize its role in the recollection of multifaceted autobiographical experiences. © 2004 Wiley‐Liss, Inc.
Cognitive Impairment in Schizophrenia and Implications of Atypical Neuroleptic Treatment

Abstract Cognitive impairment is considered a central feature of schizophrenia. Many aspects of cognition are impaired in schizophrenia. Careful evaluation of the relationship between cognitive impairment and the other symptoms of schizophrenia has revealed several important findings. In this article, we discuss these findings, the effects of typical neuroleptic therapy on cognitive impairment, and important issues to address in cognitive enhancement studies in schizophrenia.
Older consumers’ TV shopping: emotions and satisfaction

Purpose The purpose of this paper is to identify the emotional factors that affect older consumers’ satisfaction with TV shopping and examined the relationships among these factors. Design/methodology/approach A sample of 285 consumers aged 60 years and older who had watched a TV home shopping channel was used. Structural equation modeling (SEM) examined the relationships among emotional factors that affect satisfaction. Findings This study found that loneliness was an antecedent of both gratification shopping motivation and telepresence and that telepresence positively affected consumer satisfaction with TV shopping. Research limitations/implications The findings of this study validate social-compensation motive of media consumption and deficiency paradigm in the context of TV shopping. The relationship between telepresence and satisfaction also supported transportation theory. However, the findings of the current study should be interpreted with caution due to the non-random sampling method. Constructs other than those employed in this study could be examined regarding outcomes of loneliness. Practical implications This study suggested that telepresence and shopping for self-gratification are effective ways to alleviate older consumers’ loneliness. In addition, the findings from relationships among emotional variables suggested potential marketing strategies for shaping positive consumer attitudes toward and satisfaction with TV shopping networks. Originality/value This study extended knowledge on loneliness by demonstrating how it related to attitudinal outcomes such as satisfaction and knowledge on telepresence by examining it in the context of TV shopping.
Multi-Cost Optimal Route Planning Under Time-Varying Uncertainty

Different uses of a road network call for the consideration of different travel costs: in route planning, travel time and distance are typically considered, and green house gas (GHG) emissions are increasingly being considered. Further, costs such as travel time and GHG emissions are time-dependent and uncertain. To support such uses, we propose techniques that enable the construction of a multi-cost, time-dependent, uncertain graph (MTUG) model of a road network based on GPS data from vehicles that traversed the road network. Based on the MTUG, we define optimal routes that consider multiple costs and timedependent uncertainty, and we propose efficient algorithms to retrieve optimal routes for a given source-destination pair and a start time. Empirical studies with three road networks in Denmark and a substantial GPS data set offer insight into the design properties of the MTUG and the efficiency of the optimal route algorithms.
Techniques for language identification for hybrid Arabic-English document images

Because of the different characteristics of Arabic language and Romance and Anglo Saxon languages, recognition of documents written in hybrids of these languages requires that the language of the text is to be identified prior to the recognition phase. In this paper, three efficient techniques that can be used to discriminate between text written in Arabic script and text written in English script are presented and evaluated. These techniques address the language identification problem on the word level and on text level. The characteristics of horizontal projection profiles as well as runlength histograms for text written in both languages are the basic features underlying these techniques. Solving this problem is very important in building bilingual document image analysis systems which are capable of processing documents containing hybrid Arabic/Romance and Anglo Saxon languages.
Embedded MRAM for high-speed computing

As the fabrication technology node shrinks down to 90nm or below, high standby power becomes one of the major critical issues for CMOS high-speed computing circuits (e.g. logic and cache memory) due to the high leakage currents. A number of non-volatile storage technologies such as FeRAM, MRAM, PCRAM and RRAM and so on, are under investigation to bring the non-volatility into the logic circuits and then eliminate completely the standby power issue. Thanks to its infinite endurance, high switching/sensing speed and easy 3D integration after CMOS process, MRAM is considered as the most promising one. Numerous logic circuits based on MRAM technology have been proposed and prototyped in the last years. In this paper, we present an overview and current status of these logic circuits and discuss their potential applications in the future from both the physics and architecture points of view.
Comprehending Expository Texts: The Role of Cognitive and Motivational Factors

This study explored the differential contribution of cognitive and motivational factors on the comprehension of an expository text in secondary school students. One hundred and fifty-five 7th and 8th grade students were assessed in prior knowledge, inferences, metacognition, reading motivation, topic interest, and reading comprehension of history text. According to the multiple regression analyses, inferences and self-efficacy uniquely contributed to reading comprehension. Intrinsic motivation moderated the association between metacognition and reading comprehension of a history text. These results confirm that the final outcome of reading comprehension greatly depends on a complex interplay between cognitive and motivational variables.
PENGARUH KOMITMEN ORGANISASI DAN KOMITMEN PROFESIONALTERHADAP KEPUASAN KERJA AKUNTAN PUBLIK:ROLE STRESS SEBAGAI VARIABEL MODERATING

The purpose of this research is to analyzed the influence of organizational commitment, professional commitment to job satisfaction of public accountants with a role stress as moderating variable. The samples of this research are 44 public accountants that worked at public accountants office which registered in Yogyakarta and Semarang. The data were analyzed by multiple regression method with moderating variable.The result of this analysis of individual test show that role conflict is not moderated of relation by organizational commitment with job satisfaction. Also with role ambiguity which not moderated or relation by organizational commitment with job satisfaction. The main practical implication of this research is that the public accountants organizational must be attention to jobs expectation of their auditors. Because that is the factors that rising the organizational commitment and in the future it will be to give a high school satisfaction.
Digit span and verbal fluency tests in patients with mild cognitive impairment and normal subjects in Thai-community.

BACKGROUND Far too little attention has been paid to the difference of Digit Span test and category verbal fluency test (CVFT) between normal and mild cognitive impairment (MCI) subjects. OBJECTIVE To investigate the difference of Digit Span test and CVFT between normal subjects and patients with MCI and study the influence of age, gender, and education on the task performance. MATERIAL AND METHOD The authors collected data of 77 participants diagnosed with amnestic MCI (from 517 participants screened) and 30 normal subjects aged 50 or over enrolled from communities in Bangkok. The Digit Span test and CVFT (semantic fluency and Controlled word association test for letter fluency) were used to evaluate the subjects. RESULTS MCI patients had significantly lower digit span score, in both Digits Forward and Digits Backward, poorer performance on semantic fluency for animals and fruits and letter fluency test. The logistic regression model of MCI diagnosis showed that only Digits Backward score was a predictor of MCI diagnosis (OR 0.643 for each increment of 1 digit, p = 0.009, 95% confidence interval 0.462-0.896). The cut-off point of Digit Backward score was 4 and yielded sensitivity of 77% and specificity of 57%. Females had lower scores than males in every test except semantic fluency for fruits. The digit span and semantic fluency scores decreased as age increased but letter fluency increased correspondently with age. The digit span and CVFT scores increased in parallel with the increase of education. CONCLUSION MCI patients had poorer performance on the Digit Span and CVFT tests than normal age and education matched subjects. Digits Backward test can predict the MCI diagnosis. Age, gender and education have an impact on the performance of the tests.
Spectrally resolved bioluminescence tomography with adaptive finite element : methodology and simulation

As a molecular imaging technique, bioluminescence tomography (BLT) with its highly sensitive detection and facile operation can significantly reveal molecular and cellular information in vivo at the whole-body small animal level. However, because of complex photon transportation in biological tissue and boundary detection data with high noise, bioluminescent sources in deeper positions generally cannot be localized. In our previous work, we used achromatic or monochromatic measurements and a priori permissible source region strategy to develop a multilevel adaptive finite-element algorithm. In this paper, we propose a spectrally solved tomographic algorithm with a posteriori permissible source region selection. Multispectral measurements, and anatomical and optical information first deal with the nonuniqueness of BLT and constrain the possible solution of source reconstruction. The use of adaptive mesh refinement and permissible source region based on a posteriori measures not only avoids the dimension disaster arising from the multispectral measured data but also reduces the ill-posedness of BLT and therefore improves the reconstruction quality. Reconsideration to the optimization method and related modifications further enhance reconstruction robustness and efficiency. We also incorporate into the method some improvements for reducing computational burdens. Finally, using a whole-body virtual mouse phantom, we demonstrate the capability of the proposed BLT algorithm to reconstruct accurately bioluminescent sources in deeper positions. In terms of optical property errors and two sources of discernment in deeper positions, this BLT algorithm represents the unique predominance for BLT reconstruction. (Some figures in this article are in colour only in the electronic version) 0031-9155/07/000001+16$30.00 © 2007 IOP Publishing Ltd Printed in the UK 1
Discussion Paper No . 2002 / 68 E-business and Export Behaviour Evidence from Indian Firms

The paper identifies and analyses the factors that influenced the export performance of firms in the post-liberalization era of the Indian economy. The study is based on primary data collected from fifty-one firms located in the national capital region. Entrepreneurial characteristics, historical data of firms, and other firm-specific factors such as size of operation, export intensity, international orientation, wage rates, and profit margins were included in the analysis. The findings of the study suggest that the performance of firms that have adopted more advanced e-business tools has been better than others in international markets, as also that size of operation has played an important role in the export performance of firms. It is found that export-oriented firms employ more skilled workforce and the labour productivity of these firms is higher than others.
An autosomal dominant major gene confers predisposition to pulmonary tuberculosis in adults

The molecular basis of genetic predisposition to pulmonary tuberculosis in adults remains largely elusive. Few candidate genes have consistently been implicated in tuberculosis susceptibility, and no conclusive linkage was found in two previous genome-wide screens. We report here a genome-wide linkage study in a total sample of 96 Moroccan multiplex families, including 227 siblings with microbiologically and radiologically proven pulmonary tuberculosis. A genome-wide scan conducted in half the sample (48 families) identified five regions providing suggestive evidence (logarithm of the odds [LOD] score >1.17; P < 0.01) for linkage. These regions were then fine-mapped in the total sample of 96 families. A single region of chromosome 8q12-q13 was significantly linked to tuberculosis (LOD score = 3.49; P = 3 × 10−5), indicating the presence of a major tuberculosis susceptibility gene. Linkage was stronger (LOD score = 3.94; P = 10−5) in the subsample of 39 families in which one parent was also affected by tuberculosis, whereas it was much lower (LOD score = 0.79) in the 57 remaining families without affected parents, supporting a dominant mode of inheritance of the major susceptibility locus. These results provide direct molecular evidence that human pulmonary tuberculosis has a strong genetic basis, and indicate that the genetic component involves at least one major locus with a dominant susceptibility allele.
The Contagion of Great Power War Behavior, 1495-1975

Hypotheses regarding short-term contagion in the outbreak of war involving the Great Powers were tested using war data for the modern Great Power system, 1495-1975. The analysis demonstrates the likelihood of initiation of a new war to be slightly greater during an ongoing war but not after its termination. Neither war's incidence-its seriousness along any or all of several dimensions-nor its frequency had any impact on the subsequent outbreak of war in the period immediately following.
Revisiting the relationship between job demands and job performance: The effects of job security and traditionality

textabstractThe findings on the relationship between job demands and job performance have been inconsistent in previous studies. Drawing on social exchange theory, we examined the moderating effect of job security on the job demands-job performance relationship. Three studies with cross-sectional and time-lagged designs were conducted. The results of Studies 1 and 2 consistently demonstrated that job demands significantly improved employee performance in the context of higher job security, whereas job demands impaired performance to some extent when job security was lower. Study 3 replicated these findings and also showed that the positive moderating effect was stronger for employees with lower rather than higher levels of traditionality. The importance of job security to improving employees' performance in stressful workplaces was affirmed. These findings contribute to theories linking job demands to job performance and have practical implications for managers in high-stress environments, especially in developing countries. Practitioner points: Job demands may lead to good performance when employees' job security is high. Appropriate human resource practices should promise employees' perceived job security rather than only reducing job demands. Employers should pay more attention to maintaining the social exchange relationships with employees having lower traditional values.