Miracle-dz/UniFAR-FTUs huggingface dataset:
Combining Crisis Management and Evidence-Based Management

Natural disasters, such as floods, provide teachable moments for students to learn about crisis management. The authors argue that evidence-based management offers a pedagogical tool for leveraging these teachable moments to deepen student learning about the management challenges of crisis situations. An emerging area in management education, evidence-based management involves using best available scientific evidence as the basis for management decision making and practice. Using data from 782 student assignments in an undergraduate introductory management course, the authors show how combining crisis management and evidence-based management in an assignment task in the aftermath of the 2010-2011 Queensland floods in Australia deepened student learning of general and crisis management concepts and increased students’ engagement in learning an evidence-based management approach.
Primitive Roles for Inhibitory Interneurons in Developing Frog Spinal Cord

Understanding the neuronal networks in the mammal spinal cord is hampered by the diversity of neurons and their connections. The simpler networks in developing lower vertebrates may offer insights into basic organization. To investigate the function of spinal inhibitory interneurons in Xenopus tadpoles, paired whole-cell recordings were used. We show directly that one class of interneuron, with distinctive anatomy, produces glycinergic, negative feedback inhibition that can limit firing in motoneurons and interneurons of the central pattern generator during swimming. These same neurons also produce inhibitory gating of sensory pathways during swimming. This discovery raises the possibility that some classes of interneuron, with distinct functions later in development, may differentiate from an earlier class in which these functions are shared. Preliminary evidence suggests that these inhibitory interneurons express the transcription factor engrailed, supporting a probable homology with interneurons in developing zebrafish that also express engrailed and have very similar anatomy and functions.
Exploring population spatial concentrations in Northern Ireland by community background and other characteristics: an application of geographically weighted spatial statistics

Information on how populations are spatially concentrated by different characteristics is a key means of guiding government policies in a variety of contexts, in addition to being of substantial academic interest. In particular, to reduce inequalities between groups, it is necessary to understand the characteristics of these groups in terms of their composition and their geographical structure. This article explores the degree to which the population of Northern Ireland is spatially concentrated by a range of characteristics. There is a long history of interest in residential segregation by religion in Northern Ireland; this article assesses population concentration not only by community background (‘religion or religion brought up in’) but also by housing tenure, employment and other socioeconomic and demographic characteristics. The spatial structure of geographical variables can be captured by a range of spatial statistics including Moran's I. Such approaches utilise information on connections between observations or the distances between them. While such approaches are conceptually an improvement on standard aspatial statistics, a logical further step is to compute statistics on a local basis on the grounds that most real-world properties are not spatially homogenous and, therefore, global measures may mask much variation. In population geography, which provides the substantive focus for this article, there are still relatively few studies that assess in depth the application of geographically weighted statistics for exploring population characteristics individually and for exploring relations between variables. This article demonstrates the value of such approaches by using a variety of geographically weighted statistical measures to explore outputs from the 2001 Census of Population of Northern Ireland. A key objective is to assess the degree to which the population is spatially divided, as judged by the selected variables. In other words, do people cluster more strongly with others who share their community background or others who have a similar socioeconomic status in some respect? The analysis demonstrates how geographically weighted statistics can be used to explore the degree to which single socioeconomic and demographic variables and relations between such variables differ at different spatial scales and at different geographical locations. For example, the results show that there are regions comprising neighbouring areas with large proportions of people from the same community background, but with variable unemployment levels, while in other areas the first case holds true but unemployment levels are consistently low. The analysis supports the contention that geographical variations in population characteristics are the norm, and these cannot be captured without using local methods. An additional methodological contribution relates to the treatment of counts expressed as percentages.
Bounds on the complex permittivity of polycrystalline materials by analytic continuation

An analytic continuation method for obtaining rigorous bounds on the effective complex permittivity ε* of polycrystalline composite materials is developed. It is assumed that the composite consists of many identical anisotropic crystals, each with a unique orientation. The key step in obtaining the bounds involves deriving an integral representation for ε*, which separates parameter information from geometrical information. Forward bounds are then found using knowledge of the single crystal permittivity tensor and mean crystal orientation. Inverse bounds are also developed, which recover information about the mean crystal orientation from ε*. We apply the polycrystalline bounds to sea ice, a critical component of the climate system. Different ice types, which result from different growth conditions, have different crystal orientation and size statistics. These characteristics significantly influence the fluid transport properties of sea ice, which control many geophysical and biogeochemical processes important to the climate and polar ecosystems. Using a two-scale homogenization scheme, where the single crystal tensor is numerically computed, forward bounds for sea ice are obtained and are in excellent agreement with columnar sea ice data. Furthermore, the inverse bounds are also applied to sea ice, helping to lay the groundwork for determining ice type using remote sensing techniques.
Production and Perception of the /i/-/I/ Vowel Contrast: The Case of L2-Dominant Early Learners of English

Abstract The present study explored the production and perception of the /i/-/I/ vowel contrast in second language (L2)-dominant early learners of American English who no longer fluently speak their first language (L1, Spanish). The production task analyzed the extent to which the early learner group differed from controls (native English speakers and L1-Spanish late-onset learners of English) with regard to duration and spectral centroids. The perception experiment examined how these early learners classified resynthesized stimuli drawn from the /i/-/I/ contrast using distinct acoustic cues - spectral and temporal - in a 2-alternative forced choice identification task. The first experiment revealed that the early learners produced the contrast in a native-like manner in terms of the spectral envelope and duration use. The second experiment found that early learners differed from both control groups in how they categorized the /i/-/I/ continua based on spectrum and duration, and the extent to which they rely on these two cues. The effects of linguistic experience on L2 phonetic behavior are discussed.
Work stress has negative effects on the attitudes of emergency personnel towards patients who attempt suicide

ABSTRACT– Many previous studies indicate that the attitudes of the staff towards patients who attempt suicide are often negative. Nevertheless, the attitudes of the staff working in different areas of an emergency department have not been studied. The purpose of this study was to explain the attitudes of emergency personnel (n= 184) towards patients who attempt suicide in the different stages of treatment in a general hospital by comparing the attitudes of the staff in the emergency room (n= 64), emergency ward (n= 47) and intensive care unit (n= 73). There were clear differences in attitudes of staff in the various units. The attitudes were most negative among emergency room staff, where all attempters are first treated. The intensive care staff, who treat the most serious cases, shared the most positive attitudes. It seems that specialized treatment of suicide attempters makes it possible to treat these patients in a more professional way in a general hospital.
Circulating MiR-125b as a Marker Predicting Chemoresistance in Breast Cancer

Background Chemotherapy is an important component in the treatment paradigm for breast cancers. However, the resistance of cancer cells to chemotherapeutic agents frequently results in the subsequent recurrence and metastasis. Identification of molecular markers to predict treatment outcome is therefore warranted. The aim of the present study was to evaluate whether expression of circulating microRNAs (miRNAs) can predict clinical outcome in breast cancer patients treated with adjuvant chemotherapy. Methodology/Principal Findings Circulating miRNAs in blood serum prior to treatment were determined by quantitative Real-Time PCR in 56 breast cancer patients with invasive ductal carcinoma and pre-operative neoadjuvant chemotherapy. Proliferating cell nuclear antigen (PCNA) immunostaining and TUNEL were performed in surgical samples to determine the effects of chemotherapy on cancer cell proliferation and apoptosis, respectively. Among the miRNAs tested, only miR-125b was significantly associated with therapeutic response, exhibiting higher expression level in non-responsive patients (n = 26, 46%; p = 0.008). In addition, breast cancers with high miR-125b expression had higher percentage of proliferating cells and lower percentage of apoptotic cells in the corresponding surgical specimens obtained after neoadjuvant chemotherapy. Increased resistance to anticancer drug was observed in vitro in breast cancer cells with ectopic miR-125b expression; conversely, reducing miR-125b level sensitized breast cancer cells to chemotherapy. Moreover, we demonstrated that the E2F3 was a direct target of miR-125b in breast cancer cells. Conclusions/Significance These data suggest that circulating miR-125b expression is associated with chemotherapeutic resistance of breast cancer. This finding has important implications in the development of targeted therapeutics for overcoming chemotherapeutic resistance in novel anti-cancer strategies.
The Role of Femoroacetabular Impingement in Core Muscle Injury/Athletic Pubalgia: Diagnosis and Management

Chronic groin pain in athletes represents a major diagnostic and therapeutic challenge in sports medicine. Two recognized causes of inguinal pain in the young adult athlete are core muscle injury/athletic pubalgia (CMI/AP) and femoroacetabular impingement (FAI). CMI/AP and FAI were previously considered to be two distinct entities; however, recent studies have suggested both entities to frequently coincide in the athlete with groin pain. This article briefly discusses the role of FAI in CMI/AP and the diagnosis and management of this complex disease.
Differences in hospital resource allocation among sick newborns according to insurance coverage.

OBJECTIVE To assess whether newborns' insurance coverage was associated with differences in the allocation of hospital services. DESIGN Retrospective analysis of computerized hospital discharge data, comparing resource allocation among newborns according to insurance status, controlling for race/ethnicity, diagnoses, hospital characteristics (ownership, teaching status, nursery level), and disposition. SETTING All California civilian acute-care hospitals. PATIENTS Population-based sample, excluding out-of-hospital and military hospital births. Resource allocation was studied among all newborns discharged in 1987 with evidence of serious problems (N = 29,751). MAIN OUTCOME MEASURES Length of stay, total charges, and charges per day. RESULTS Sick newborns without insurance received fewer inpatient services than comparable privately insured newborns with either indemnity or prepaid coverage. This pattern was observed across all hospital ownership types. Mean stay was 15.7 days for all privately insured newborns (15.6 days for those with indemnity and 15.7 days for those with prepaid coverage), 14.8 days for Medicaid-covered newborns, and 13.2 days for uninsured newborns (P less than .001). Length of stay, total charges, and charges per day were 16%, 28%, and 10% less, respectively, for the uninsured than for all privately insured newborns (P less than .001). Resources for newborns covered by Medicaid were generally greater than for the uninsured and less than for the privately insured. Both uninsured and Medicaid-covered newborns were found to have more severe medical problems than the privately insured. CONCLUSIONS The findings cannot be explained by differences in medical need or by differences in non-medically indicated services; they constitute prima facie evidence of inequities that need to be addressed by policy changes.
Representing Musical Genre: A State of the Art

Musical genre is probably the most popular music descriptor. In the context of large musical databases and Electronic Music Distribution, genre is therefore a crucial metadata for the description of music content. However, genre is intrinsically ill-defined and attempts at defining genre precisely have a strong tendency to end up in circular, ungrounded projections of fantasies. Is genre an intrinsic attribute of music titles, as, say, tempo? Or is genre a extrinsic description of the whole piece? In this article, we discuss the various approaches in representing musical genre, and propose to classify these approaches in three main categories: manual, prescriptive and emergent approaches. We discuss the pros and cons of each approach, and illustrate our study with results of the Cuidado IST project.
Working memory, response inhibition, and within-subject variability in children with attention-deficit/hyperactivity disorder or reading disorder

This study compared children with ADHD (n = 19), reading disorder (RD; n = 17), ADHD+RD (n = 21), and control children (n = 19) on linguistic and executive function measures. We found no evidence of response inhibition problems in ADHD or RD when a baseline measure of functioning was taken into account. General working memory problems were only found in children with RD or ADHD+RD. Both children with ADHD and RD showed a highly inaccurate (more commission errors) and variable (higher within-subject standard deviation of reaction time) response style. The comorbid group made most errors, suggesting that different factors underlie the high error rate in both disorders.
Randomized Differential Testing as a Prelude to Formal Verification

Most flight software testing at the Jet Propulsion Laboratory relies on the use of hand-produced test scenarios and is executed on systems as similar as possible to actual mission hardware. We report on a flight software development effort incorporating large-scale (biased) randomized testing on commodity desktop hardware. The results show that use of a reference implementation, hardware simulation with fault injection, a testable design, and test minimization enabled a high degree of automation in fault detection and correction. Our experience will be of particular interest to developers working in domains where on-time delivery of software is critical (a strong argument for randomized automated testing) but not at the expense of correctness and reliability (a strong argument for model checking, theorem proving, and other heavyweight techniques). The effort spent in randomized testing can prepare the way for generating more complete confidence using heavyweight techniques.
Photosynthesis , carboxylation and leaf nitrogen responses of 16 species to elevated pCO 2 across four free-air CO 2 enrichment experiments in forest , grassland and desert

The magnitude of changes in carboxylation capacity in dominant plant species under long-term elevated CO2 exposure (elevated pCa) directly impacts ecosystem CO2 assimilation from the atmosphere. We analyzed field CO2 response curves of 16 C3 species of different plant growth forms in favorable growth conditions in four free-air CO2 enrichment (FACE) experiments in a pine and deciduous forest, a grassland and a desert. Among species and across herb, tree and shrub growth forms there were significant enhancements in CO2 assimilation (A) by 1 40 5% in elevated pCa (49.5– 57.1 Pa), although there were also significant reductions in photosynthetic capacity in elevated pCa in some species. Photosynthesis at a common pCa (Aa) was significantly reduced in five species growing under elevated pCa, while leaf carboxylation capacity (Vcmax) was significantly reduced by elevated pCa in seven species (change of 19 3% among these species) across different growth forms and FACE sites. Adjustments in Vcmax with elevated pCa were associated with changes in leaf N among species, and occurred in species with the highest leaf N. Elevated pCa treatment did not affect the mass-based relationships between A or Vcmax and N, which differed among herbs, trees and shrubs. Thus, effects of elevated pCa on leaf C assimilation and carboxylation capacity occurred largely through changes in leaf N, rather than through elevated pCa effects on the relationships themselves. Maintenance of leaf carboxylation capacity among species in elevated pCa at these sites depends on maintenance of canopy N stocks, with leaf N depletion associated with photosynthetic capacity adjustments. Since CO2 responses can only be measured experimentally on a small number of species, understanding elevated CO2 effects on canopy Nm and Na will greatly contribute to an ability to model responses of leaf photosynthesis to atmospheric CO2 in different species and plant growth forms.
The Locus for Hypoglycemic Detection Shifts With the Rate of Fall in Glycemia

OBJECTIVE—To ascertain whether portal glucose sensing extends beyond the portal vein to the superior mesenteric vein and then test whether the role of portal–superior mesenteric glucose sensors varies with the rate of fall in glycemia. RESEARCH DESIGN AND METHODS—Chronically cannulated rats underwent afferent ablation of the portal vein (PV) or portal and superior mesenteric veins (PMV) or sham operation (control). One week later, animals underwent hyperinsulinemic-hypoglycemic clamps in which the hypoglycemic nadir, 2.48 ± 0.06 mmol/l, was reached at a rate of decline in glucose of −0.09 or −0.21 mmol · l−1 · min−1 (PMV and control only). Additional PMV and control animals received an intravenous injection of the glucopenic agent 2-deoxyglucose. RESULTS—Inducing hypoglycemia slowly, at a rate of −0.09 mmol · l−1 · min−1, resulted in a 26-fold increase in epinephrine (23.39 ± 0.62 nmol/l) and 12-fold increase in norepinephrine (11.42 ± 0.92 nmol/l) for controls (P < 0.001). The epinephrine response to hypoglycemia was suppressed by 91% in PMV (2.09 ± 0.07 nmol/l) vs. 61% in PV (9.05 ± 1.59 nmol/l) (P < 0.001). The norepinephrine response to hypoglycemia was suppressed by 94 and 80% in PMV and PV, respectively, compared with that in controls. In contrast, when arterial glucose was lowered to 2.49 ± 0.06 mmol/l within 20 min, no significant differences were observed in the catecholamine responses for PMV and controls over the first 45 min of hypoglycemia (20–65 min). Only at min 105 were catecholamines significantly lower for PMV vs. controls. Injection of 2-deoxyglucose induced a very rapid sympathoadrenal response with no significant differences between PMV and controls. CONCLUSIONS—The critical locus for hypoglycemic detection shifts away from the portal-mesenteric vein to some other loci (e.g., the brain) when hypoglycemia develops rapidly.
Effect of Aging on the Prognostic Significance of Ambulatory Systolic, Diastolic, and Pulse Pressure in Essential Hypertension

Background—This study compared the relative prognostic significance of 24 hour intra-arterial ambulatory systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), and pulse pressure (PP) parameters in middle-aged versus elderly hypertensives. Methods and Results—A total of 546 subjects aged <60 years and 142 subjects aged ≥60 years who had undergone baseline pretreatment 24-hour intra-arterial ambulatory blood pressure monitoring were followed for 9.2±4.1 years. Multivariate analysis showed that in younger subjects, 24-hour, daytime, and nighttime DBP, MAP, and SBP, when considered individually, were positively related to morbid events; DBP parameters provided the best predictive values. In the group ≥60 years (elderly group), 24-hour, daytime, and nighttime PP and SBP were the most predictive parameters, whereas ambulatory DBP and MAP measurements failed to provide any prognostic value. When 24-hour values of SBP and DBP were jointly included in the baseline model, DBP (z=2.02, P =0.04) but not SBP (z=−0.43, P =0.67) was related to outcome in younger subjects, whereas in the elderly group, SBP (z=3.33, P =0.001) was positively and DBP (z=−1.75, P =0.07) was negatively related to outcome. Clinic blood pressure measurements failed to provide any independent prognostic value in either age group. Conclusions—The relative prognostic significance of ambulatory blood pressure components depends on age; DBP parameters provided the best prognostic value in middle-aged individuals, whereas PP parameters were the most predictive in the elderly. This may reflect differing underlying hemodynamic mechanisms of hypertension in these age groups.
Existence and uniqueness of risk-sensitive estimates

Risk-sensitive criteria have been used to derive robust filters, identifiers, and controllers. The fundamental issues of existence and uniqueness of an estimate of a random variable given a random vector with respect to an order-(/spl lambda/, p) risk-sensitive criterion are studied in this note. More precisely, we prove the existence of a unique risk-sensitive estimate provided /spl lambda/>0 and p>1. For the remaining cases, a general existence result is not available at this time. We do, however, prove the existence in certain special cases. Moreover, we present examples with uncountably many optimal risk-sensitive estimates, i.e., exhibiting an extremely high level of nonuniqueness.
Store memory-level parallelism optimizations for commercial applications

This paper studies the impact of off-chip store misses on processor performance for modern commercial applications. The performance impact of off-chip store misses is largely determined by the extent of their overlap with other off-chip cache misses. The epoch MLP model is used to explain and quantify how these overlaps are affected by various store handling optimizations and by the memory consistency model implemented by the processor. The extent of these overlaps is then translated to off-chip CPI. Experimental results show that store handling optimizations are crucial for mitigating the substantial performance impact of stores in commercial applications. While some previously proposed optimizations, such as store prefetching, are highly effective, they are unable to fully mitigate the performance impact of off-chip store misses and they also leave a performance gap between the stronger and weaker memory consistency models. New optimizations, such as the store miss accelerator, an optimization of hardware scout and a new application of speculative lock elision, are demonstrated to virtually eliminate the impact of off-chip store misses