Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of beta adrenoceptor antagonists on baroreceptor reflex sensitivity in hypertension

High‐pressure baroreceptor reflex sensitivity (BRS) was estimated by measuring the reflex heart rate response to pharmacologic elevation olblood pressure (phenylephrine, 150 to 200 f.Lg intravenously) in 18 patients with essential hypertension on two occasions: after a 4‐wk placebo period and after 9 wk of incremental doses of oral timolol (20, 40, and 60 mg daily). On placebo, measurements were pelformed both before and after propranolol (0.2 mglkg intravenously). The level of cardiac vagal inhibition, estimated by the heart rate change alter atropine (0.04 mglkg intravenously), was similar on placebo and on timolol, thereby permitting comparisons of BRS. BRS on placebo (belore and after propranolol) correlated with BRS on timolol (r = 0.87 and 0.90, p < 0.001), attesting to the reproducibility of BRS measurements. BRS was unchanged by either short‐term (propranolol) or long‐term (timolof) beta adrenoceptor inhibition. Results were similar in responders (n = 10), whose mean arterial blood pressure on timolol fell by 10 mm Hg or more, and in nonresponders. The findings do not provide evidence for a change in gain of the baroreceptor reflex arc under conditions of short‐ or long‐term beta adrenoceptor inhibition.
Modeling and performance analysis using extended fuzzy-timing Petri nets for networked virtual environments

Despite their attractive properties, networked virtual environments (net-VEs) are notoriously difficult to design, implement, and test due to the concurrency, real-time and networking features in these systems. Net-VEs demand high quality-of-service (QoS) requirements on the network to maintain natural and real-time interactions among users. The current practice for net-VE design is basically trial and error, empirical, and totally lacks formal methods. This paper proposes to apply a Petri net formal modeling technique to a net-VE-NICE (narrative immersive constructionist/collaborative environment), predict the net-VE performance based on simulation, and improve the net-VE performance. NICE is essentially a network of collaborative virtual reality systems called the CAVE-(CAVE automatic virtual environment). First, we introduce extended fuzzy-timing Petri net (EFTN) modeling and analysis techniques. Then, we present EFTN models of the CAVE, NICE, and transport layer protocol used in NICE: transmission control protocol (TCP). We show the possibility analysis based on the EFTN model for the CAVE. Then, by using these models and design/CPN as the simulation tool, we conducted various simulations to study real-time behavior, network effects and performance (latencies and jitters) of NICE. Our simulation results are consistent with experimental data.
AN INNER QUALITY APPROACH TO REDUCING STRESS AND IMPROVING PHYSICAL AND EMOTIONAL WELLBEING AT WORK

This exploratory field study examined the impact of an Inner Quality Management program (IQM) on a group of Motorola employees. IQM is a training program designed to help people increase productivity through improved health, communication, goal clarity, positive mood and job satisfaction, and through the reduction of tension, burnout, physical symptoms of stress and negative mood. Both psychological and physiological measures were assessed in the 6-month study. The study involved three groups: managers, engineers and factory workers. Results showed that contentment, job satisfaction and communication significantly increased after the training, while tension, anxiety, nervousness and physical symptoms of stress significantly decreased. Blood pressure in hypertensive individuals decreased, and there was a reduction in sympathetic nervous activity. Implications for workplace wellbeing are discussed. © 1997 John Wiley & Sons, Ltd.
Divulgação de informações ambientais nas demonstrações contábeis: um estudo estudo exploratório sobre o disclosure das empresas brasileiras pertecentes a setores de alto impacto ambiental

O objetivo deste trabalho e examinar as informacoes ambientais divulgadas voluntariamente pelas empresas brasileiras. O levantamento dessas informacoes foi realizado a partir das Demonstracoes Financeiras Padronizadas (DFPs) de 2006. A tecnica utilizada foi a analise de conteudo, sendo que optou-se pelo numero de sentencas como unidade de registro. A amostra do estudo consiste nas empresas listadas na Bolsa de Valores de Sao Paulo (BOVESPA), e pertencentes a setores de alto impacto ambiental segundo a Lei n°. 10.165/2000, que dispoe sobre a Politica Nacional do Meio Ambiente. Os resultados evidenciam que a categoria com maior numero de sentencas e a de "Politicas Ambientais", seguida pela de "Informacoes Financeiras Ambientais". A maioria das informacoes e declarativa, do tipo positiva, localizada no Relatorio da Administracao e nao auditada. Esses resultados corroboram a Teoria do Disclosure Voluntario e os estudos anteriores, na medida em que nao se esperava que as empresas divulgassem voluntariamente informacoes negativas a respeito de suas praticas ambientais.
Student teacher challenges: using the cognitive load theory as an explanatory lens

Cognitive load theory (CLT) can explain the challenges faced by student teachers. This study, guided by the CLT, included 26 pre-service teachers. Participants completed a cognitive load self-report questionnaire and were interviewed at two points during their student teaching. Results revealed that student teachers decreased mental effort related to monitoring their students’ level of attention, meeting needs of diverse learners, and managing internal and external distractions. Qualitative analysis revealed: (1) student teachers became aware of limited cognitive resources; (2) lesson planning imposes cognitive load during student teaching; and (3) cognitive overload limits the ability to make modifications during teaching.
Functional interrelationships between the adenohypophysis, thyroid, adrenal cortex and gonads.

an area in which many kinds of knowledge are brought together to deal with the hormonal integration of bodily processes. Three types of approach have been made to the subject: (1) a description of the phenomena, (2) an analysis of mechanisms, and (3) attempts to reconstruct the whole sequence from dissected fragments. During the first half of this century, activity in this field has been largely concerned with the description of hormonal effects and the isolation and characterization of compounds which produce these effects. The last two decades have witnessed a vigorous growth of analytical approaches to en¬ docrinology and the beginning of
Gender stereotypes : perception or rationalization?

It is proposed that gender stereotypes arise to rationalize the distribution of the sexes into social roles. Ss read descriptions of members of two fictional categories, one having 80% «city workers» and 20% «child raisers», the other with the percentages reversed. They late made personality ratings of each category and of the category subgroups occupying each role
The lexicogrammatical reflection of interpersonal relationship in conversation

This article reports an attempt to investigate, apart from the semantics and the pragmatics, how much the lexis and the grammar of a conversation can help extract interpersonal information about the interlocutors' orientations towards each other. The discourse analysed was extracted from a scene in Dan Brown's novel The Da Vinci Code and its motion picture adaptation. The adaptation of this scene is similar to the novel original in terms of the characters' content of discussion and only differs in the orientation of the characters to one another. The analysis focuses on the determination of response types, which are generally classified as either expected or discretionary, and contribute to the realization of positive and negative orientations respectively. The distribution of different types of response is visualized as the interlocutor's `response profile', which helps in the realization of his/her orientation to the one to whom he/she is responding.
Cost-Effectiveness of Treatments for Relapsing Remitting Multiple Sclerosis: A French Societal Perspective

Objectives The paper aimed to estimate the incremental cost-effectiveness ratio (ICER) at the public published price for delayed-release dimethyl fumarate versus relevant Multiple Sclerosis disease-modifying therapies available in France in June 2015. Methods The economic model was adapted to the French setting in accordance with the Haute Autorité de Santé guidelines using a model previously developed for NICE. A cohort of Relapsing Remitting Multiple Sclerosis patients was simulated over a 30-year time horizon. Twenty one health states were taken into account: Kurtzke Expanded Disability Status Scale (EDSS) 0–9 for Relapsing Remitting Multiple Sclerosis patients, EDSS 0–9 for Secondary Progressive Multiple Sclerosis patients, and death. Estimates of relative treatment efficacy were determined using a mixed-treatment comparison. Probabilities of events were derived from the dimethyl fumarate pivotal clinical trials and the London Ontario Dataset. Costs and utilities were extracted from the published literature from both the payer and societal perspectives. Univariate and probabilistic sensitivity analyses were performed to assess the robustness of the model results. Results From both perspectives, dimethyl fumarate and interferon beta-1a (IFN beta-1a) 44mcg were the two optimal treatments, as the other treatments (IFN beta-1a 30mcg, IFN beta-1b 250mcg, teriflunomide, glatiramer acetate, fingolimod) were dominated on the efficiency frontier. From the societal perspective, dimethyl fumarate versus IFN beta-1a 44mcg incurred an incremental cost of €3,684 and an incremental quality-adjusted life year (QALY) of 0.281, corresponding to an ICER of €13,110/QALY. Conclusions Despite no reference threshold for France, dimethyl fumarate can be considered as a cost-effective option as it is on the efficiency frontier.
Tubulin‐β‐III overexpression by uterine serous carcinomas is a marker for poor overall survival after platinum/taxane chemotherapy and sensitivity to epothilones

Uterine serous carcinoma (USC) is a subtype of endometrial cancer associated with chemoresistance and poor outcome. Overexpression of tubulin‐β‐III and p‐glycoprotein has been linked to paclitaxel resistance in many cancers but has been undercharacterized among USCs. Epothilones have demonstrated activity in certain paclitaxel‐resistant malignancies. In this study, relationships are clarified, in USCs relative to ovarian serous carcinomas (OSCs), between tubulin‐β‐III and p‐glycoprotein expression, clinical outcome, and in vitro chemoresponsiveness to epothilone B, ixabepilone, and paclitaxel.
Dual coordinate solvers for large-scale structural SVMs

This manuscript describes a method for training linear SVMs (including binary SVMs, SVM regression, and structural SVMs) from large, out-of-core training datasets. Current strategies for large-scale learning fall into one of two camps; batch algorithms which solve the learning problem given a finite datasets, and online algorithms which can process out-of-core datasets. The former typically requires datasets small enough to fit in memory. The latter is often phrased as a stochastic optimization problem; such algorithms enjoy strong theoretical properties but often require manual tuned annealing schedules, and may converge slowly for problems with large output spaces (e.g., structural SVMs). We discuss an algorithm for an "intermediate" regime in which the data is too large to fit in memory, but the active constraints (support vectors) are small enough to remain in memory. In this case, one can design rather efficient learning algorithms that are as stable as batch algorithms, but capable of processing out-of-core datasets. We have developed such a MATLAB-based solver and used it to train a collection of recognition systems for articulated pose estimation, facial analysis, 3D object recognition, and action classification, all with publicly-available code. This writeup describes the solver in detail.
Sequencing of the porB Gene: a Step toward a True Characterization of Neisseria meningitidis

ABSTRACT Variations in class 2/3 (PorB) proteins form the basis for meningococcal serotyping. Antibodies against these proteins are bactericidal, making serotyping results useful not only for epidemiological surveillance of meningococcal disease but also for identifying potential vaccine components. A total of 20 to 60% of meningococcal B and C isolates from any given population are nontypeable (NT) using a panel of monoclonal antibodies. To analyze the mechanisms responsible for the nonserotypeability characteristic in Neisseria meningitidis, we (i) established the nucleotide sequences of porB gene in 146 meningococcal strains (95 not recognized by the serotyping panel), (ii) identified 18 new allelic variants of the porB gene, (iii) correlated allelic variants with serotypes, (iv) suggest the nontypeability characteristic in those 95 NT strains, and (v) reject the possibility of variation in the levels of PorB expression.
Segmentation and Mobility: An Analysis of Labour Market Flows on the Danish Labour Market

During the last decade the segmentation theory approach has been very popular among labour-market researchers It has been attempted to use this theory to explain differentiation and marginalization on the labour market in many European countries. This article describes a Danish research project which aims at an analysis of the segmentation on the Danish labour market and its consequences for the labour-market attachment of different groups of workers The central themes in the article are partly the development of a sociological theory of segmentation and partly the relation between segmentation and mobility on the Danish labour market.
Preferences for popular music in and outside school among Chinese secondary school students

During the last two decades, China has experienced the emergence of vibrant popular music, resulting from globalisation and commercialisation. This empirical study investigates Chinese secondary students' popular music preferences in daily life, and to what extent and in what ways they prefer learning about popular music in school in the city of Changsha. Based on the findings from the survey questionnaires completed by 1816 secondary school students and interviews with 45 students from 8 secondary schools, this study revealed that Chinese teenagers preferred popular music styles in their daily lives and in school, particularly popular songs from Mainland China, the USA and the UK. There was a strong relationship found between school music teachers and the students' preferences for learning popular songs. Many of the students surveyed had their own popular music idols, but they mostly maintained that they liked their music idols because of their songs' melodies and lyrics. The findings also showed that there was a gap between the students' preferences for popular music and the popular music styles taught in school music lessons. Despite the division of classical and popular music learning among Chinese youths, most students conceded that these two musical styles should be taught in school music education. This study's findings challenge the notion of how popular music education in a culturally diverse community can be improved, as well as stimulate further examination of young students' music preferences in and outside the school environment.
H2-M3, a full-service class Ib histocompatibility antigen.

H2-M3 is an MHC class Ib molecule of the mouse with a unique preference for N-formylated peptides, which may come from the N-termini of endogenous, mitochondrial proteins or foreign, bacterial proteins. The crystal structure of M3 revealed a hydrophobic peptide-binding groove with an occluded A pocket and the peptide shifted one residue relative to class Ia structures. The formyl group is held by a novel hydrogen bonding network, involving His9 on the bottom of the groove, and the side chain of the P1 methionine is lodged in the B pocket. M3 is a full-service histocompatibility (H) antigen, i.e. self-M3 can present endogenous peptides as minor H antigens and foreign, bacterial antigens in a defensive immune response to infection; and foreign M3 complexed with endogenous self-peptides.
ENTEROBACTERIACEAE AND PSEUDOMONADACEAE ON THE DORSUM OF THE HUMAN TONGUE

Objective: The aim of this study was to correlate the presence of Enterobacteriaceae, Pseudomonadaceae, Moraxellaceae and Xanthomonadaceae on the posterior dorsum of the human tongue with the presence of tongue coating, gender, age, smoking habit and denture use. Material and Methods: Bacteria were isolated from the posterior tongue dorsum of 100 individuals in MacConkey agar medium and were identified by the API 20E system (Biolab-Mérieux). Results: 43% of the individuals, presented the target microorganisms on the tongue dorsum, with greater prevalence among individuals between 40 and 50 years of age (p = 0.001) and non-smokers (p=0.0485). Conclusions: A higher prevalence of Enterobacteriaceae and Pseudomonadaceae was observed on the tongue dorsum of the individuals evaluated. There was no correlation between these species and the presence and thickness of tongue coating, gender and presence of dentures.
The Development of Social Knowledge: Morality and Convention

Preface 1. Introduction: approaches to the study of social knowledge 2. Structure and development 3. Social experience and social knowledge 4. Dimensions of social judgments 5. Rules and prohibitions 6. The development of concepts of social convention and coordination of domains 7. The development of moral judgments 8. Noncognitive approaches to moral development: internalization and biological determinism 9. Social judgments and actions: coordination of domains 10. Conclusions: interaction, development, and rationality References Index.
APPLE: Advanced Procedural Programming Language Elements

Today’s programming languages, in particular aspect-oriented languages such as AspectJ [8], have received a considerable degree of complexity, making it both hard to learn their “vocabulary” (i. e., simply know all concepts and constructs offered by the language) and to “fluently speak” them (i. e., successfully apply these concepts and constructs in daily programming). In contrast, traditional procedural languages, such as Pascal or C, provided just two basic building blocks: data structures (records in particular) and procedures operating on them [1]. Modern procedural languages, such as Modula-2 or Ada, added the concept of modules to support encapsulation and information hiding [9]. In objectoriented languages such as Eiffel, Java, or C++, these separate and orthogonal entities have been combined into classes which offer subtype polymorphism, inheritance of data structures and procedures (which are usually called methods there), and dynamic binding of procedures as additional basic concepts. Even though object-oriented languages support the construction of software that is usually more flexible, extensible, and reusable than traditional “procedural software,” it soon turned out that many desirable properties are still missing. For example, modular extensibility (i. e., the ability to extend an existing system without modifying or recompiling its source code) is limited to adding new (sub)classes to a class hierarchy, while adding new operations (methods) to existing classes is impossible. Similarly, retroactively extending or modifying the behaviour of operations is infeasible. A great deal of research efforts have been expended in the past years to overcome these limitations by providing even more new concepts, e. g. , open classes [3] or advice and inter-type member declarations in aspect-oriented languages [8], to name only a few. Even though the set of these additional concepts is “sufficient” (in the sense that they indeed solve the problems encountered with object-oriented languages), the question arises whether they are really “necessary” (in the sense that a smaller or simpler set of concepts would not be sufficient). Using AspectJ as an extreme example, this language provides eight more or less different kinds of “procedures,” i. e. , named blocks of executable code: static methods, instance methods and constructors defined in classes (as in the base language Java), plus instance methods and constructors defined as inter-type members in aspects, plus before, after, and around advice (still neglecting the distinction between “after returning,” “after throwing,” and general “after” advice).
Insights into Light‐driven DNA Repair by Photolyases: Challenges and Opportunities for Electronic Structure Theory

Ultraviolet radiation causes two of the most abundant mutagenic and cytotoxic DNA lesions: cyclobutane pyrimidine dimers and 6‐4 photoproducts. (6‐4) Photolyases are light‐activated enzymes that selectively bind to DNA and trigger repair of mutagenic 6‐4 photoproducts via photoinduced electron transfer from flavin adenine dinucleotide anion (FADH−) to the lesion triggering repair. This review provides an overview of the sequential steps of the repair process, that is light absorption and resonance energy transfer, photoinduced electron transfer and electron‐induced splitting mechanisms, with an emphasis on the role of theory and computation. In addition, theoretical calculations and physical properties that can be used to classify specific mechanism are discussed in an effort to trace the fundamental aspects of each individual step and assist the interpretation of experimental data. The current challenges and suggested future directions are outlined for each step, concluding with a view on the future.
Can the meaning of multiple words be integrated unconsciously?

What are the limits of unconscious language processing? Can language circuits process simple grammatical constructions unconsciously and integrate the meaning of several unseen words? Using behavioural priming and electroencephalography (EEG), we studied a specific rule-based linguistic operation traditionally thought to require conscious cognitive control: the negation of valence. In a masked priming paradigm, two masked words were successively (Experiment 1) or simultaneously presented (Experiment 2), a modifier (‘not’/‘very’) and an adjective (e.g. ‘good’/‘bad’), followed by a visible target noun (e.g. ‘peace’/‘murder’). Subjects indicated whether the target noun had a positive or negative valence. The combination of these three words could either be contextually consistent (e.g. ‘very bad - murder’) or inconsistent (e.g. ‘not bad - murder’). EEG recordings revealed that grammatical negations could unfold partly unconsciously, as reflected in similar occipito-parietal N400 effects for conscious and unconscious three-word sequences forming inconsistent combinations. However, only conscious word sequences elicited P600 effects, later in time. Overall, these results suggest that multiple unconscious words can be rapidly integrated and that an unconscious negation can automatically ‘flip the sign’ of an unconscious adjective. These findings not only extend the limits of subliminal combinatorial language processes, but also highlight how consciousness modulates the grammatical integration of multiple words.