Miracle-dz/UniFAR-FTUs huggingface dataset:
eNOS3 Genetic Polymorphism Is Related to Post-Ablation Early Recurrence of Atrial Fibrillation

Purpose Previous studies have demonstrated an association between eNOS polymorphisms and atrial fibrillation (AF). We sought to determine whether eNOS polymorphisms are associated with AF recurrence after a radiofrequency catheter ablation (RFCA). Materials and Methods A total of 500 consecutive patients (56±11 years, 77% male) with paroxysmal (68%) or persistent (32%) AF who underwent RFCA and 500 age, gender-matched controls were genotyped for the eNOS3 single nucleotide polymorphism (rs1799983). AF recurrence was monitored according to 2012 ACC/AHA/ESC guidelines. Results The frequencies of the rs1799983 variant alleles (T) in the case and control group were not significantly different (OR 1.05, 95% CI 0.75-1.46, p=0.798). AF patients with rs1799983 variants were more likely to have coronary artery disease or stroke than those without genetic variant at this gene (31.0% vs. 17.3%, p=0.004). During mean 17 months follow-up, early recurrence of AF (ERAF; within 3 months) and clinical recurrence (CR) of AF were 31.8% and 24.8%, respectively. The rs1799983 variant was associated with higher risk of ERAF (OR 1.71, 95% CI 1.06-2.79, p=0.028), but not with CR. ERAF occurred earlier (11±16 days) in variant group than those without variant allele (20±25 days, p=0.016). A multiple logistic regression analysis showed that presence of the rs1799983 variant (OR 1.75, 95% CI 1.07-2.86, p=0.026) and persistent AF were independent predictors for ERAF after AF ablation. Conclusion The rs1799983 variant of the eNOS3 gene was associated with ERAF, but not with CR, after RFCA. eNOS3 gene variants may have a potential role for stratification of post-ablation management.
On the H I content, dust-to-gas ratio and nature of Mg II absorbers

We estimate the mean dust-to-gas ratio of Mg ii absorbers as a function of rest equivalent width W0 and redshift over the range 0.5 < z < 1.4. Using the expanded Sloan Digital Sky Survey/Hubble Space Telescope sample of low-redshift Lyman-α absorbers, we first show the existence of a 8σ correlation between the mean hydrogen column density 〈NH i〉 and W0, an indicator of gas velocity dispersion. By combining these results with recent dust-reddening measurements, we show that the mean dust-to-gas ratio of Mg ii absorbers does not appreciably depend on rest equivalent width. Assuming that, on average, dust-to-gas ratio is proportional to metallicity, we find its redshift evolution to be consistent with that of L★ galaxies from z= 0.5 to 1.4, and we show that our constraints disfavour dwarf galaxies as the origin of such absorbers. We discuss other scenarios and favour galactic outflows from ∼L★ galaxies as the origin of the majority of strong Mg ii absorbers. Finally, we show that, once evolutionary effects are taken into account, the Bohlin et al. relation between AV and NH is also satisfied by strong Mg ii systems down to lower column densities than those probed in our Galaxy.
Association of coronary artery disease with polymorphisms of angiotensin-converting enzyme and methylenetetrahydrofolate reductase gene.

OBJECTIVE Angiotensin-converting enzyme plays an important role in maintaining blood pressure, while methylenetetrahydrofolate reductase is involved in homocysteine metabolism. As hypertension and elevated homocysteine levels are among the various risk factors for coronary artery disease, the two polypeptides might need to be considered while determining the risk. Our study aimed to assess the association between common polymorphisms in these genes and susceptibility to coronary artery disease. METHODS We studied 268 north Indian individuals with coronary artery disease and 90 age-matched controls. The distribution of the genotypes and allele frequencies of both genes were analyzed using polymerase chain reaction amplification and restriction fragment length polymorphism analysis. RESULTS The frequency of the D allele was significantly higher among the patients (62%) than the controls (44%) (p=0.001, odds ratio=2.06). The same goes for the DD genotype (37% vs 21%) (p=0.004). The combined frequency of the D allele carriers was significantly higher among patients of coronary heart disease, with a difference of 20% (85% vs 65%) (p=0.003, odds ratio=3.1; CI: 1.3-7.29). However, the frequency of the T and C alleles, as well as that of the CC, CT and TT genotypes of the methylenetetrahydrofolate reductase gene, did not differ significantly between the two groups. CONCLUSION We conclude that coronary artery disease in north Indian patients is strongly associated with the carrier state of the angiotensin-converting enzyme D allele, but not with the C677T transition in the methylenetetrahydrofolate reductase gene.
What Can Economists Learn from Happiness Research?

Over the past few years, there has been a steadily increasing interest on the part of economists in happiness research. We argue that reported subjective well-being is a satisfactory empirical approximation to individual utility and that happiness research is able to contribute important insights for economics. We report how the economic variables income, unemployment and inflation affect happiness as well as how institutional factors, in particular the type of democracy and the extent of government decentralization, systematically influence how satisfied individuals are with their life. We discuss some of the consequences for economic policy and for economic theory.
Linkage disequilibrium and diversity for three genomic regions in Azoreans and mainland Portuguese

Studies on linkage disequilibrium (LD) across the genome and populations have been used in recent years with the main objective of improving gene mapping of complex traits. Here, we characterize the patterns of genetic diversity of HLA loci and evaluate LD (D') extent in three genomic regions: Xq13.3, NRY and HLA. In addition, we examine the distribution of DXS1225-DXS8082 haplotype diversity in Azoreans and mainland Portuguese. Allele distribution has demonstrated that the São Miguel population is genetically very diverse; haplotype analysis revealed 100% discriminatory power for X- and Y-markers and 94.3% for HLA markers. Standardized multiallelic D' in these three genomic regions shows values lower than 0.33, thereby suggesting there is no extensive LD in the São Miguel population. Data regarding the distribution of DXS1225-DXS8082 haplotypes indicate that there are no significant differences among all the populations studied, (Azorean geographical groups, the Azores archipelago and mainland Portugal). Moreover, in these as well as in other European populations, the most frequent DXS1225-DXS8082 haplotype is 210-219. Even though São Miguel islanders and Azoreans do not constitute isolated populations and show LD for only very short physical distances, certain characteristics, such as the absence of genetic structure, the same environment and the possibility of constructing extensive pedigrees through church and civil records, offer an opportunity for dissecting the genetic background of complex diseases in these populations.
A Lie and a Mistress: On Increasing the Believability of Your Alibi

The present study was designed to assess whether or not the presentation method and the salaciousness of an alibi affect its evaluation. Community participants (n = 150) were asked to evaluate the salacious or non-salacious alibi of a crime suspect. The alibi was either presented immediately after arrest by the suspect or was changed after the initial alibi turned out to be incorrect. The incorrect alibi was due to either a misrecollection or a deliberate lie. We found that when the initial alibi was changed into a salacious one, the believability increased. This effect was larger when the initial alibi was a lie than when it was a misrecollection. The results of the present study demonstrate that, contrary to common belief, a changed salacious alibi can lead to an increase in alibi believability.
PLANCK COLD CLUMPS IN THE λ ORIONIS COMPLEX. I. DISCOVERY OF AN EXTREMELY YOUNG CLASS 0 PROTOSTELLAR OBJECT AND A PROTO-BROWN DWARF CANDIDATE IN THE BRIGHT-RIMMED CLUMP PGCC G192.32–11.88

We are performing a series of observations with ground-based telescopes toward Planck Galactic cold clumps (PGCCs) in the λ Orionis complex in order to systematically investigate the effects of stellar feedback. In the particular case of PGCC G192.32–11.88, we discovered an extremely young Class 0 protostellar object (G192N) and a proto-brown dwarf candidate (G192S). G192N and G192S are located in a gravitationally bound bright-rimmed clump. The velocity and temperature gradients seen in line emission of CO isotopologues indicate that PGCC G192.32–11.88 is externally heated and compressed. G192N probably has the lowest bolometric luminosity (∼0.8 L ☉ ? > ) and accretion rate (6.3 × 10−7 M ☉ ? > yr−1) when compared with other young Class 0 sources (e.g., PACS Bright Red Sources) in the Orion complex. It has slightly larger internal luminosity (0.21 ± 0.01 L ☉ ? > ) and outflow velocity (∼14 km s−1) than the predictions of first hydrostatic cores (FHSCs). G192N might be among the youngest Class 0 sources, which are slightly more evolved than an FHSC. Considering its low internal luminosity (0.08 ± 0.01 L ⊙ ? > ) and accretion rate (2.8 × 10−8 M ☉ ? > yr−1), G192S is an ideal proto-brown dwarf candidate. The star formation efficiency (∼0.3%–0.4%) and core formation efficiency (∼1%) in PGCC G192.32–11.88 are significantly smaller than in other giant molecular clouds or filaments, indicating that the star formation therein is greatly suppressed owing to stellar feedback.
Prevalence of Substance Use in a Sample of Ghanaian Adolescents Experiencing Parental Divorce

ABSTRACT Using a cross-sectional nonexperimental design and a convenience sample of 240 adolescents between the ages of 14 and 19 years, this study investigated the prevalence of substance use among adolescents experiencing parental divorce in Ghana. The relative influence of factors such as adolescents' sex, class level, age at parental divorce, and years of experience with parental divorce on the use of substances were also examined. The Adolescent Substance Use Checklist (ASUC) was administered during class hours. Descriptive, bivariate and multivariate analyses were conducted. The results obtained showed that lifetime ever use of substances was 48.8% (N=117), with alcohol being the common used substance by adolescents. Adolescent males were as likely as females to use substances (OR=1.37, CI=.807 –2.325). A significant relationship was found between class level, age at parental divorce, and substance use (p < .05 for both relationships). These two risk factors also proved to be significant predictors of substance use.
Meta-analysis of the effect of consistency on success in early learning of programming

A test was designed that apparently examined a student’s knowledge of assignment and sequence before a first course in programming but in fact was designed to capture their reasoning strategies. An experiment found two distinct populations of students: one could build and consistently apply a mental model of program execution; the other appeared either unable to build a model or to apply one consistently. The first group performed very much better in their end-ofcourse examination than the second in terms of success or failure. The test does not very accurately predict levels of performance, but by combining the result of six replications of the experiment, five in UK and one in Australia. we show that consistency does have a strong effect on success in early learning to program but background programming experience, on the other hand, has little or no effect.
Giving up Twitter for Lent: how and why we take breaks from social media

Social media use is widespread, but many people worry about overuse. This paper explores how and why people take breaks from social media. Using a mixed methods approach, we pair data from users who tweeted about giving up Twitter for Lent with an interview study of social media users. We find that 64% of users who proclaim that they are giving up Twitter for Lent successfully do so. Among those who fail, 31% acknowledge their failure; the other 69% simply return. We observe hedging patterns (e.g. "I thought about giving up Twitter for Lent but"? ) that surfaced uncertainty about social media behavior. Interview participants were concerned about the tradeoffs of spending time on social media versus doing other things and of spending time on social media rather than in "real life. " We discuss gaps in related theory that might help reduce users' anxieties and open design problems related to designing systems and services that can help users manage their own social media use.
Pharmacotherapeutic considerations for use of cannabinoids to relieve pain in patients with malignant diseases

Purpose The aim of this review was to assess the efficacy of cannabis preparations for relieving pain in patients with malignant diseases, through a systematic review of randomized controlled trials (RCTs), which were predominantly double-blind trials that compared cannabis preparation to a placebo. Methods An electronic search of all literature published until June 2017 was made in MEDLINE/PubMed, Embase, The Cochrane Controlled Trials Register and specific web pages devoted to cannabis. Results Fifteen of the 18 trials demonstrated a significant analgesic effect of cannabinoids as compared to placebo. The most commonly reported adverse effects were generally well tolerated, mild to moderate. The main side effects were drowsiness, nausea, vomiting and dry mouth. There is evidence that cannabinoids are safe and modestly effective in neuropathic pain and also for relieving pain in patients with malignant diseases. The proportion of “responders” (patients who at the end of 2 weeks of treatment reported ≥30% reduction in pain intensity on a scale of 0–10, which is considered to be clinically important) was 43% in comparison with placebo (21%). Conclusion The target dose for relieving pain in patients with malignant diseases is most likely about 10 actuations per day, which is about 27 mg tetrahydrocannabinol (THC) and 25 mg cannabidiol (CBD), and the highest approved recommended dose is 12 actuations per day (32 mg THC/30 mg CBD). Further large studies of cannabinoids in homogeneous populations are required.
ACPA-positive primary Sjögren's syndrome: true primary or rheumatoid arthritis-associated Sjögren's syndrome?

Objectives Anticyclic citrullinated protein antibodies (ACPA) are highly specific of rheumatoid arthritis (RA). However, they have also been detected in 5–10% of primary Sjögren's syndrome (pSS). We compared ACPA-positive and negative patients with pSS and assessed the risk of evolution to RA. Patients and methods ACPA-positive and negative patients with pSS were included in this study. For ACPA-positive patients, clinical and radiological re-evaluation was systematically performed after at least 5 years of follow-up. Diagnosis was reassessed at the end of the follow-up to identify patients that developed RA according to the American College of Rheumatology 1987 classification criteria. Results At inclusion in the cohort 16 patients with pSS were ACPA positive and 278 were ACPA negative. ACPA-positive patients, had more frequently arthritis (43.7% vs 12.2%; p=0.003) but not arthralgias. They also had more frequent lung involvement (25% vs 8.1%; p=0.05). After median follow-up of 8 (5–10) years, 7/16 (43.8%) patients developed RA including 5 (31.25%) with typical RA erosions. Elevation of acute phase reactants at inclusion was the only parameter associated with progression to erosive RA. Conclusions Median term follow-up of ACPA-positive patients with pSS showed that almost half of them developed RA, particularly in the presence of elevation of acute phase reactants. These results support the usefulness of a close radiological monitoring of these patients for early detection of erosive change not to delay initiation of effective treatment. Indeed, number of these patients with ACPA-positive pSS may actually have RA and associated SS.
Spectral Theory for Periodically and Almost Periodically Correlated Random Processes: A Survey

This paper contains a survey of the spectral theory of periodically correlated and almost periodically correlated stochastic processes. These processes are also called cyclostationary and almost cyclostationary, and we give give some remarks concerning the historical development of the two nomenclatures. In this paper we survey the spectral theory of the covariance, the estimation of the Fourier coeecient functions and their corresponding spectral densities, and the spectral representation of the covariance and the process when the process is harmonizable. In addition, we review the role of the unitary operator and the spectral theory for groups of unitary operators in obtaining representations for these processes. This paper appears under the title \Representation and Estimation for Periodically and Almost Periodically Correlated Random Processes" in Cy
Efficient Space-Time Sampling with Pixel-Wise Coded Exposure for High-Speed Imaging

Cameras face a fundamental trade-off between spatial and temporal resolution. Digital still cameras can capture images with high spatial resolution, but most high-speed video cameras have relatively low spatial resolution. It is hard to overcome this trade-off without incurring a significant increase in hardware costs. In this paper, we propose techniques for sampling, representing, and reconstructing the space-time volume to overcome this trade-off. Our approach has two important distinctions compared to previous works: 1) We achieve sparse representation of videos by learning an overcomplete dictionary on video patches, and 2) we adhere to practical hardware constraints on sampling schemes imposed by architectures of current image sensors, which means that our sampling function can be implemented on CMOS image sensors with modified control units in the future. We evaluate components of our approach, sampling function and sparse representation, by comparing them to several existing approaches. We also implement a prototype imaging system with pixel-wise coded exposure control using a liquid crystal on silicon device. System characteristics such as field of view and modulation transfer function are evaluated for our imaging system. Both simulations and experiments on a wide range of scenes show that our method can effectively reconstruct a video from a single coded image while maintaining high spatial resolution.
A role for putamen in phonological processing in children*

Bilingual children are required to successfully develop phonological skills in two languages, yet little is known about the neural correlates associated with them. We obtained structural imaging data from 30 Hindi–English children aged between 8 and 10 years and used voxel based morphometry to explore neuroanatomical correlates of behavioural measures of phonological awareness. Our results showed that phonological skills in English are predicted by grey matter volume of bilateral putamen, but solely by right putamen in Hindi. Post-hoc analysis revealed that English nonword reading correlates with grey matter volume in bilateral putamen while in Hindi nonword reading it correlates only with right putamen. These differences in putamen-based mechanisms indicate that syllable level awareness sufficiently supports early literacy in the transparent, alphasyllabic Hindi orthography whereas that in English requires both phonemic and syllabic level awareness. Our findings point towards a key role for putamen in mediating phonological and reading skills in children.
Gummi: a bendable computer

Gummi is an interaction technique and device concept based on physical deformation of a handheld device. The device consists of several layers of flexible electronic components, including sensors measuring deformation of the device. Users interact with this device by a combination of bending and 2D position control. Gummi explores physical interaction techniques and screen interfaces for such a device. Its graphical user interface facilitates a wide range of interaction tasks, focused on browsing of visual information. We implemented both hardware and software prototypes to explore and evaluate the proposed interaction techniques.Our evaluations have shown that users can grasp Gummi's key interaction principles within minutes. Gummi demonstrates promising possibilities for new interaction techniques and devices based on flexible electronic components.
Parenting and Australian trans and gender diverse people: An exploratory survey

ABSTRACT Growing numbers of Australian trans and gender diverse people desire to become parents, yet many who do so experience a lack of support and recognition. This article reports on an online survey completed by 160 trans or gender diverse people. The survey included general demographic questions, in addition to questions related to (1) current parenting arrangements, (2) modes of family formation, (3) the desire to have children in the future, and (4) support or discrimination from families of origin. In regard to the findings, only a minority of participants (39) were already parents; however 21 participants indicated that they desired to have children in the future. Participants who were already parents were older than those who were not, and conversely, participants who desired to have children in the future were younger than those who did not. Discrimination from family of origin was negatively correlated with support for parenting, while support from family of origin was positively correlated with desire to have children. The paper concludes by suggesting that support from service providers is important for this potentially vulnerable group who may not experience support from their families of origin and who may perceive themselves as having limited pathways to parenthood.
Automatic Evaluation of Speech Rhythm Instability and Acceleration in Dysarthrias Associated with Basal Ganglia Dysfunction

Speech rhythm abnormalities are commonly present in patients with different neurodegenerative disorders. These alterations are hypothesized to be a consequence of disruption to the basal ganglia circuitry involving dysfunction of motor planning, programing, and execution, which can be detected by a syllable repetition paradigm. Therefore, the aim of the present study was to design a robust signal processing technique that allows the automatic detection of spectrally distinctive nuclei of syllable vocalizations and to determine speech features that represent rhythm instability (RI) and rhythm acceleration (RA). A further aim was to elucidate specific patterns of dysrhythmia across various neurodegenerative disorders that share disruption of basal ganglia function. Speech samples based on repetition of the syllable /pa/ at a self-determined steady pace were acquired from 109 subjects, including 22 with Parkinson’s disease (PD), 11 progressive supranuclear palsy (PSP), 9 multiple system atrophy (MSA), 24 ephedrone-induced parkinsonism (EP), 20 Huntington’s disease (HD), and 23 healthy controls. Subsequently, an algorithm for the automatic detection of syllables as well as features representing RI and RA were designed. The proposed detection algorithm was able to correctly identify syllables and remove erroneous detections due to excessive inspiration and non-speech sounds with a very high accuracy of 99.6%. Instability of vocal pace performance was observed in PSP, MSA, EP, and HD groups. Significantly increased pace acceleration was observed only in the PD group. Although not significant, a tendency for pace acceleration was observed also in the PSP and MSA groups. Our findings underline the crucial role of the basal ganglia in the execution and maintenance of automatic speech motor sequences. We envisage the current approach to become the first step toward the development of acoustic technologies allowing automated assessment of rhythm in dysarthrias.