Miracle-dz/UniFAR-FTUs huggingface dataset:
Atypical squamous cells, cannot exclude high‐grade squamous intraepithelial lesion

Current guidelines recommend colposcopy rather than high‐risk human papillomavirus (HPV) testing for the evaluation of abnormal cervical cytology interpreted as “atypical squamous cells, cannot exclude high‐grade squamous intraepithelial lesion“ (ASC‐H) based on data from the Atypical Squamous Cells of Undetermined Significance/Low‐Grade Squamous Intraepithelial Lesion (ASCUS/LSIL) Triage Study (ALTS), which indicated that ASC‐H had a significantly greater frequency of high‐risk HPV positivity and underlying high‐grade squamous intraepithelial lesions (HSIL) compared with ASCUS. The cytologic interpretations in the ALTS were expert consensus diagnoses rather than routine, single‐pathologist readings.
Do Japanese Insurers Benefit from A Catastrophic Event?: Market Reactions to the 1995 Hanshin–Awaji Earthquake

Abstract Several studies have examined the “gaining from loss” hypothesis, whereby insurance companies' market valuation increases after a natural disaster because the anticipated subsequent increase in demand for coverage is presumed by investors to outweigh the effects of capital outflow from insurance companies for claims payments. Previous studies investigating how stock markets assessed the impact of big earthquakes in the United States (e.g., the 1989 Loma Prieta earthquake) found that insurance firm values did indeed increase following such catastrophes. This is the first paper to test this hypothesis using a case outside the United States. Specifically, we investigate how the Japanese stock market reassessed domestic insurance firm values after the 1995 Hanshin–Awaji earthquake. Contrary to the findings based on U.S. earthquakes, we found negative stock price reactions. Another important finding is that Japanese stock markets were notably efficient in assessing information following the earthquake. J. Japan. Int. Econ. , March 2002, 16 (1) pp. 92–108. Graduate School of Economics, Nagoya University, Nagoya, 464-8601, Japan and School of Economics, Chukyo University, Nagoya, 466-8666, Japan. © 2002 Elsevier Science (USA). Journal of Economic Literature Classification Numbers: G-22, G-14.
Cross-validation of the Beunen–Malina method to predict adult height

Abstract The purpose of this study was to cross-validate the Beunen–Malina method for non-invasive prediction of adult height. Three hundred and eight boys aged 13, 14, 15 and 16 years from the Madeira Growth Study were observed at annual intervals in 1996, 1997 and 1998 and re-measured 7–8 years later. Height, sitting height and the triceps and subscapular skinfolds were measured; skeletal age was assessed using the Tanner–Whitehouse 2 method. Adult height was measured and predicted using the Beunen–Malina method. Maturity groups were classified using relative skeletal age (skeletal age minus chronological age). Pearson correlations, mean differences and standard errors of estimate (SEE) were calculated. Age-specific correlations between predicted and measured adult height vary between 0.70 and 0.85, while age-specific SEE varies between 3.3 and 4.7 cm. The correlations and SEE are similar to those obtained in the development of the original Beunen–Malina method. The Beunen–Malina method is a valid method to predict adult height in adolescent boys and can be used in European populations or populations from European ancestry. Percentage of predicted adult height is a non-invasive valid method to assess biological maturity.
Do Managers Use Meeting Analyst Forecasts to Signal Private Information? Evidence from Patent Citations

This study examines whether firms manage earnings to meet analyst forecasts to signal superior future performance. Prior research finds that firms use earnings management to just meet analyst forecasts and that these firms have a positive association with future performance (Bartov et al., 2002). There are two potential explanations for the positive association – signaling and attaining benefits that allow for better future performance (i.e., the real benefits explanation). Prior studies cannot provide evidence of signaling because they do not control for the real benefits explanation. Our research design enables us to control for the real benefits explanation because we can identify potential signaling firms within the sample of firms that just meet analyst forecasts. We use a unique database from the National Bureau of Economic Research to construct a proxy for the manager's belief about future firm value due to patents. We find that firms with more patent citations are more likely to just meet the analyst forecast and manage earnings to achieve this goal. We also find firms that just meet analyst forecasts with more patent citations have significantly better performance than firms with fewer patent citations, which is consistent with signaling and not the real benefits explanation.
[Effect of occupational stress and effort-reward imbalance on sleep quality of people's policeman].

OBJECTIVE To explore the effect of occupational stress and effort-reward imbalance on sleep quality of people's police. METHODS A cluster sampling survey of sleep quality and occupational stress correlated factors was conducted on 287 police from a city public security bureau by questionnaires in May, 2011; the relationship between sleep quality and occupational stress correlated factors was analyzed by one-way ANOVA and multivariate non-conditional logistic regression using effort-reward imbalance model (ERI) and demand-control-support model (DCS). And the subjects were divided into high tension group and low tension group using the 1.0 of ERI and DCS coefficients as the boundary. RESULTS The sleep quality score of shift work police was higher than day work police (11.95 ± 6.54 vs 9.52 ± 6.43, t = 2.77, P < 0.05). In ERI model, the sleep quality score in high tension group was higher than low tension group (14.50 ± 6.41 vs 8.60 ± 5.53, t = -5.32, P < 0.01), and in DCS model, the sleep quality score in high tension group was also higher than low tension group (13.71 ± 6.62 vs 9.46 ± 6.04, t = -3.71, P < 0.01). For the regression analysis of ERI model as an argument, sex (OR = 3.0, 95%CI:1.16-7.73) , age for 30-39 years (OR = 3.48, 95%CI:1.32-9.16) , intrinsic effort (OR = 2.30, 95%CI:1.10-4.81) and daily hassles (OR = 2.15, 95%CI:1.06-4.33) were risk factors of low sleep quality, and reward (OR = 0.26, 95%CI:0.12-0.52) was the protective factor.For the regression analysis of DCS model as an argument , age for 30-39 years (OR = 2.55, 95%CI:1.02-6.37) , depressive symptom (OR = 2.10, 95%CI:1.14-3.89) and daily hassles (OR = 3.25, 95%CI:1.70-6.19) were risk factors of low sleep quality.While the ERI model and the DCS model were analyzed simultaneously, sex (OR = 3.03, 95%CI:1.15-7.98) , age for 30-39 years (OR = 3.71, 95%CI:1.38-9.98) and daily hassles (OR = 2.09, 95%CI:1.01-4.30) were the risk factors of low sleep quality, and reward (OR = 0.22, 95%CI:0.10-0.48) was the protective factor. CONCLUSION Occupational stress and effort-reward imbalance affected the sleep quality to people's policeman.
Trust and Power in Land Politics in South Africa

Land politics is of high practical and symbolic importance in much of Africa. South Africa is no exception. Here it is investigated from two angles. First from a discussion of trust and a culture of trustworthiness as conditions for the functioning of modern institutions. Second from an interest in how the administrative level of communities and/or political cultures gives form to the relations between authority and subjects or, more generally, in modernity to the relation between state and society. Western South Africa was chosen for the investigation as there are no homelands. ‘Land-reformed’ communities in two provinces, Northern and Western Cape, are compared. The study showed (1) that the ANC’s land policy is increasingly an expression of a unified government–bureaucracy–modern economy élite; (2) that there are specific barriers to the formation of cultures of trustworthiness in institutions of authority (commercial farmers, lack of horizontal communication and the power of ethnicity), barriers blocking ‘embedded authorities’; and (3) that trust in government with respect to land policies is waning, despite progress in the redistribution of land.
Poverty reduction : does reproductive health matter?

Funding for the reproductive health agenda agreed at the 1994 International Conference on Population and Development has fallen short of estimated requirements. In the changed funding environment, stronger evidence on the links between reproductive health and poverty reduction is needed. This paper reviews the evidence base on three reproductive health outcomes: early childbearing, maternal survival, and unintended pregnancy. Building on the “capacities” approach to poverty assessment advocated by Amartya Sen, this evidence is organized in a framework that includes health and education outcomes for mothers and children as well as household consumption and production effects. Generally speaking, the evidence on health effects is strongest, household well-being weakest, and education in between. Causal relationships are difficult to establish because reproductive health outcomes and other household-level explanatory variables are influenced by each other. An important finding is that relationships are context specific and that one cannot look at individual characteristics without reference to contextual variables. One reason why much existing research has not effectively addressed the effects of poor reproductive health on poverty is that studies have relied on survey data for a single point in time. Longitudinal surveys offer greater promise. Rather than propose new surveys, initial research could work with existing data resources. Frankenberg and colleagues (2005) have identified and catalogued 40 survey programs that are potentially useful for this purpose. Research should focus on a country or countries where (1) there has been social and economic change over time, (2) rich-poor differences in reproductive health outcomes persist, and (3) obtaining and working with promising datasets is feasible. Pursuit of causal relationships between poor reproductive health outcomes and poverty should not paralyze efforts to make better use of existing country-level evidence in Poverty Reduction Strategies and other documents that guide resource allocation.
An empirical analysis of information in the yield spread on future recessions in Japan

This article examines whether the yield spread contains information on the likelihood of future economic recessions using a probit model by taking the stability of the relationship between the yield spread and future recessions into account. We also compare the accuracy of information in the yield spread with stock returns and money supply. We find the following results in this article. First, a structural change in the relationship between the yield spread and future recessions occur at the end of 1996. Second, whereas the Japanese yield spread contains more precise information on future recessions than stock returns and nominal money supply before the structural break, we cannot predict future recessions using the yield spread after the break. Third, the money supply does not forecast future recessions for the entire sample period.
HIV-1-suppressive factors are secreted by CD4+ T cells during primary immune responses

CD4+ T cells are required for immunity against many viral infections, including HIV-1 where a positive correlation has been observed between strong recall responses and low HIV-1 viral loads. Some HIV-1-specific CD4+ T cells are preferentially infected with HIV-1, whereas others escape infection by unknown mechanisms. One possibility is that some CD4+ T cells are protected from infection by the secretion of soluble HIV-suppressive factors, although it is not known whether these factors are produced during primary antigen-specific responses. Here, we show that soluble suppressive factors are produced against CXCR4 and CCR5 isolates of HIV-1 during the primary immune response of human CD4+ T cells. This activity requires antigenic stimulation of naïve CD4+ T cells. One anti-CXCR4 factor is macrophage-derived chemokine (chemokine ligand 22, CCL22), and anti-CCR5 factors include macrophage inflammatory protein-1α (CCL3), macrophage inflammatory protein-1β (CCL4), and RANTES (regulated upon activation of normal T cells expressed and secreted) (CCL5). Intracellular staining confirms that CD3+CD4+ T cells are the source of the prototype HIV-1-inhibiting chemokines CCL22 and CCL4. These results show that CD4+ T cells secrete an evolving HIV-1-suppressive activity during the primary immune response and that this activity is comprised primarily of CC chemokines. The data also suggest that production of such factors should be considered in the design of vaccines against HIV-1 and as a mechanism whereby the host can control infections with this virus.
Integrating African Indigenous Knowledge in Kenya’s Formal Education System: The Potential for Sustainable Development

The current paradigm shift toward promoting education for sustainable development gravitates toward alternative approaches to school curricula in Sub-Saharan Africa. It is argued that solutions to problems that currently plague the continent and with reference to the Kenyan context must proceed from understanding of local capacities such as the role of indigenous knowledge in promoting sustainable development. This can be achieved by integrating indigenous knowledge into the formal education system to address some of the knowledge deficiencies for development that is currently formulated from the western perspective. This approach challenges the dominance of western knowledge in Kenya’s school system that makes education disembodied from context. The purpose of this paper is to explore the meaning of indigenous knowledge, provide rationale for valuing indigenous knowledge in formal school system, examine the government’s efforts to indigenise curricula, and dilemmas to integrating indigenous knowledge in formal education with implications to teacher education programs.
Economic Openness and International Financial Flows

ACCELERATING INrEREST in economic integration among nations and increasing stress on the economic welfare of regions within nations have raised a new set of problems for economists in the years since World War II. Because regions within a single country and member nations of an effective economic union are likely to be highly vulnerable to shocks of external origin and to respond to economic stimuli of all kinds in ways strongly conditioned by their interdependence with the outside world, measures of the degree of an economy's involvement with the outside world are becoming increasingly relevant, in fact essential, to the formulation of effect*e economic policy. This paper is devoted to an empirical examination of various aspects of economic openness, a term used to signify a high degree of interaction with the outside world. Just because this concept of economic openness is so closely associated with the better-known concept of economic integration, a clear distinction between them is essential. The degree of economic integration is properly measured in terms of how closely a group of economies approximates a single, frictionless market, characterized in the limit by the equalization of all prices. Economic openness, as I understand and use the term, is defined in terms of the relative importance of economic flows across national (or
High burden of invasive Streptococcus agalactiae disease in South African infants

Abstract The epidemiology of invasive Streptococcus agalactiae (GBS) disease was evaluated in South African children. Records of 208/220 children in whom GBS was isolated between January 1997 and December 1999 were reviewed. These included 63%, 31.7% and 5.3% children with early- (EOD, <7 days of age), late- (LOD, age 7-90 days) and childhood-onset disease (COD, age >90 days), respectively. The overall burden of EOD and LOD were 2.06 and 1/1000 live births, respectively. The overall mortality was 19.8% and 13.6% for infants with EOD and LOD, respectively. Risk factors for mortality in infants with EOD and LOD included septic shock (82.1% vs 1.9%), prematurity (35.2% vs 9.6%), low birthweight (29.2% vs 11.0%) and a leucocyte count <5000/mm3 (43.5% vs 18.6%). Eight (72.7%) of 11 children with COD had an immunosuppressive, predisposing cause for invasive bacterial disease. In infants with EOD and LOD, serotype III isolates caused 49.2% and 75.7% of disease, respectively, and, together with serotype Ia isolates, caused 78.9% and 100% of invasive disease, respectively. Invasive GBS disease is common in South African infants and current strategies aimed at reducing the burden of the disease should be reconsidered.
On Ribosome Conservation and Evolution

The ribosome is a ribozyme whose active site, the peptidyl transferase center (PTC), is situated within a highly conserved universal symmetrical region that connects all ribosomal functional centers involved in amino acid polymerization. The linkage between this elaborate architecture and A-site tRNA position revealed that the A-> P-site passage of the tRNA terminus in the peptidyl transferase center is performed by a rotatory motion, synchronized with the overall tRNA/mRNA sideways movement. Guided by the PTC, the rotatory motion leads to stereochemistry suitable for peptide bond formation, as well as for substrate-mediated catalysis, consistent with quantum mechanical calculations elucidating the transition state mechanism for peptide bond formation and indicating that the peptide bond is being formed during the rotatory motion. Analysis of substrate binding modes to inactive and active ribosomes illuminated the significant PTC mobility and supported the hypothesis that the ancient ribosome produced sin.
Molecular dynamics simulations suggest a mechanism for translocation of the HIV-1 TAT peptide across lipid membranes

The recombinant HIV-1 Tat protein contains a small region corresponding to residues 47YGRKKRRQRR57R, which is capable of translocating cargoes of different molecular sizes, such as proteins, DNA, RNA, or drugs, across the cell membrane in an apparently energy-independent manner. The pathway that these peptides follow for entry into the cell has been the subject of strong controversy for the last decade. This peptide is highly basic and hydrophilic. Therefore, a central question that any candidate mechanism has to answer is how this highly hydrophilic peptide is able to cross the hydrophobic barrier imposed by the cell membrane. We propose a mechanism for the spontaneous translocation of the Tat peptides across a lipid membrane. This mechanism involves strong interactions between the Tat peptides and the phosphate groups on both sides of the lipid bilayer, the insertion of charged side chains that nucleate the formation of a transient pore, followed by the translocation of the Tat peptides by diffusing on the pore surface. This mechanism explains how key ingredients, such as the cooperativity among the peptides, the large positive charge, and specifically the arginine amino acids, contribute to the uptake. The proposed mechanism also illustrates the importance of membrane fluctuations. Indeed, mechanisms that involve large fluctuations of the membrane structure, such as transient pores and the insertion of charged amino acid side chains, may be common and perhaps central to the functions of many membrane protein functions.
Clinical complaints: a means of improving quality of care.

OBJECTIVES--To establish the reasons for clinical complaints, complainants' feelings about the original incident, and their motivation in complaining. DESIGN--Postal questionnaire survey. SETTING--24 hospitals in North West Thames region. SUBJECTS--1007 complainants who had written to 20 hospitals between 1 January 1992 and 30 June 1993 about a complaint involving a clinical incident. MAIN MEASURES--Personal details, the nature of the complaint, the complainant's reaction to the original incident, the quality of the explanation at the time of the incident, the reasons for making a complaint, and what would have prevented the incident. RESULTS--491 completed questionnaires were received (response rate 49%). Complaints arose from serious incidents, generally a clinical problem combined with staff insensitivity and poor communication. Clinical complaints were seldom about a clinical incident alone (54; 11%); most (353; 72%) included a clinical component and dissatisfaction with personal treatment of the patient or care. In all, 242(49%) complainants reported a need for additional medical treatment, 206(42%) reported that the patient's condition had worsened as a result of treatment, and 175(36%) that side effects had been experienced. In 26(5%) cases the patient had died. Complainants' primary motive was to prevent recurrence of a similar incident. Lack of detailed information and staff attitude were identified as important criticisms. CONCLUSIONS--The emphasis must be on obtaining a better response to complaints at the clinical level by the staff involved in the original incident, not simply on adjusting the complaints procedure. Staff training in responding to distressed and dissatisfied patients is essential, and monitoring complaints must form part of a more general risk management programme.
The Necessity of NKCC1: Loss of the Chloride Cotransporter in a Knock-Out Model and Potential Compensatory Mechanisms

During early neuronal development, GABAA receptor (GABAAR) activation typically leads to a depolarizing action, mainly because the activity of the chloride cotransporter, Na+-K+-2Cl− (NKCC1), raises chloride levels within the cell ([Cl−]i) causing Cl− to move outward through the open channels
Capital Structure and Ownership Distribution of Tender Offer Targets: An Empirical Study

This study investigates the capital and ownership structure of firms receiving tender offers. Predictions of control-driven models developed by Haris and Raviv (1988) and Stulz (1988) and value-maximizing models developed by Israel (1991, 1992) are examined. The study reports results consistent with the predictions that: 1) target firms increase leverage during control contests, 2) leverage increases are higher when the tender offer is opposed, 3) leverage increases are higher when the tender offer is unsuccessful, and 4) ownership structure is important to explaining the success of tender offers. When tested jointly with other independent variables, only capital structure is statistically significant in explaining both management's opposition and the success of a tender offer.