Miracle-dz/UniFAR-FTUs huggingface dataset:
Productivity Analysis and Impact of Colombian Psychology Journals between 2000 and 2016

espanolResumen La creciente produccion de las revistas de psicologia colombianas en las ultimas decadas lleva a preguntas sobre la relevancia e impacto regional e internacional de su productividad. Considerando la falta de esfuerzos recientes para evaluar el resultado de estas revistas en diferentes fuentes de informacion, el presente estudio analizo la produccion, colaboracion e impacto de las revistas de psicologia colombianas entre 2000 y 2016 utilizando informacion de las siguientes bases de datos: Scopus, Scielo, Redalyc, y Journal Scholar Metrics. Analizamos 3915 articulos publicados en 13 revistas. Se incluyeron las revistas que estaban indexadas en varias de estas bases de datos al tiempo durante el tiempo de observacion, lo que permitio realizar comparaciones. Observamos la diversificacion y el crecimiento de las revistas en todos los indicadores propuestos, con diferentes grados de visibilidad y calidad segun los criterios utilizados. Aunque todas las revistas en general mostraron resultados regionales e internacionales similares, algunas se destacaron en todos los indicadores, lo que a su vez invita a otras revistas a mejorar sus indicadores. Concluimos que la produccion colombiana en psicologia es visible a nivel regional. Ademas, las revistas deben aumentar algunos de los indicadores para poder compararlos con otros puntos de referencia de acceso abierto regionales e internacionales, ya que es el modelo bajo el cual se concibieron originalmente. EnglishAbstract The growing output of Colombian psychology journals over past decades leads to questions regarding the regional and international relevance and impact of their productivity. Considering the lack of recent efforts to assess the output of these journals across different information sources, the present study analyzed the production, collaboration, and impact of Colombian psychology journals between 2000 and 2016 using information from the following databases: Scopus, Scielo, Redalyc, and Journal Scholar Metrics. We analyzed 3915 articles published across 13 journals. A journal was included in the analysis if it was indexed in several of these databases, which allowed for multiple comparisons. We observed journals' diversification and growth across all the proposed indicators, with different degrees of visibility and quality depending on the criteria used. Although all the journals generally showed similar regional and international results, some excelled across indicators, which in turn challenges other journals to improve their scores. We conclude that Colombian production in psychology is visible on a regional level. Moreover, journals need to increase some of the indicators so they can be compared with other regional and international open-access benchmarks, which is the model in which they were originally conceived.
Modeling of application- and middleware-layer interaction protocols

The CONNECT Integrated Project aims at enabling continuous composition of networked systems to respond to the evolution of functionalities provided to and required from the networked environment. CONNECT aims at dropping the interoperability barrier by adopting a revolutionary approach to the seamless networking of digital systems, that is, synthesizing on-the-fly the connectors via which networked systems communicate. The resulting emergent connectors are effectively synthesized according to the behavioral semantics of application- down to middleware-layer protocols run by the interacting parties. The role of work package WP3 is to devise automated and compositional approaches to connector synthesis, which can be performed at run-time. Given the respective interaction behavior of networked systems, we want to synthesize the behavior of the connector(s) needed for them to interact. These connectors serve as mediators of the networked systems' interaction at both application and middleware layers. In this deliverable, we set the scene for a formal theory of the automated synthesis of application- and middleware-layer protocol mediators. We formally characterize mediating connectors between mismatching application-layer protocols by rigorously defining the necessary conditions that must hold for protocols to be mediated. The outcome of this formalization is the definition of two relationships between heterogenous protocols: matching and mapping. The former is concerned with checking whether a mediator letting two protocols interoperate exists or not. The latter concerns the algorithm that should be executed to synthesize the required mediator. Furthermore, we analyze the different dimensions of interoperability at the middleware layer and exploit this analysis to formalize existing solutions to middleware-layer interoperability. Since the work on application-layer mediator synthesis is based on the assumption that a model of the interaction protocol for a networked system is dynamically discovered, we finally present an approach, based on data-flow analysis and testing, for the automated elicitation of application-layer protocols from software implementations. This approach presents similarities, but also several differences, with the work of work package WP4 (protocol learning). Furthermore, it allowed us to proceed in parallel with the work of WP4 and to state the requirements that the learning approaches have to satisfy to enable mediator synthesis. For this reason, we keep this work separate from the work on protocol learning and discuss it in this deliverable. All the approaches mentioned above are applied to several examples and scenarios.
Expansion and Activation Kinetics of Immune Cells during Early Phase of GVHD in Mouse Model Based on Chemotherapy Conditioning

In the present paper, we have investigated early pathophysiological events in graft-versus-host disease (GVHD), a major complication to hematopoietic stem cell transplantation (HSCT). BLLB/c female mice conditioned with busulfan/cyclophosphamide (Bu-Cy) were transplanted with allogeneic male C57BL/6. Control group consisted of syngeneic transplanted Balb/c mice. In allogeneic settings, significant expansion and maturation of donor dendritic cells (DCs) were observed at day +3, while donor T-cells CD8+ were increased at day +5 (230%) compared to syngeneic HSCT. Highest levels of inflammatory cytokines IL-2, IFN-gamma, and TNF-alfa at day +5 matched T-cell activation. Concomitantly naïve T-cells gain effecr-memory phenotype and migrated from spleen to peripheral lymphoid organs. Thus, in the very early phase of GHVD following Bu-Cy conditioning donor, DCs play an important role in the activation of donor T cells. Subsequently, donor naïve T-cells gain effector-memory phenotype and initiate GVHD.
Structure–Function Aspects of PstS in Multi-Drug–Resistant Pseudomonas aeruginosa

The increasing prevalence of multi-drug–resistant (MDR) strains of Pseudomonas aeruginosa among critically ill humans is of significant concern. In the current study, we show that MDR clinical isolates of P. aeruginosa representing three distinct genotypes that display high virulence against intestinal epithelial cells, form novel appendage-like structures on their cell surfaces. These appendages contain PstS, an extracellular phosphate binding protein. Using anti-PstS antibodies, we determined that the PstS-rich appendages in MDR strains are involved in adherence to and disruption of the integrity of cultured intestinal epithelial cell monolayers. The outer surface–expressed PstS protein was also identified to be present in P. aeruginosa MPAO1, although to a lesser degree, and its role in conferring an adhesive and barrier disruptive phenotype against intestinal epithelial cells was confirmed using an isogenic ΔPstS mutant. Formation of the PstS rich appendages was induced during phosphate limitation and completely suppressed in phosphate-rich media. Injection of MDR strains directly into the intestinal tract of surgically injured mice, a known model of phosphate limitation, caused high mortality rates (60%–100%). Repletion of intestinal phosphate in this model completely prevented mortality. Finally, significantly less outer surface PstS was observed in the MPAO1 mutant ΔHxcR thus establishing a role for the alternative type II secretion system Hxc in outer surface PstS expression. Gene expression analysis performed by RT-PCR confirmed this finding and further demonstrated abundant expression of pstS analogous to pa5369, pstS analogous to pa0688/pa14–55410, and hxcX in MDR strains. Taken together, these studies provide evidence that outer surface PstS expression confers a highly virulent phenotype of MDR isolates against the intestinal epithelium that alters their adhesive and barrier disrupting properties against the intestinal epithelium.
Essential Requirement for C-KIT and Common γ Chain in Thymocyte Development Cannot Be Overruled by Enforced Expression of Bcl-2

The thymus in mice lacking both the receptor tyrosine kinase c-kit and the common cytokine receptor γ chain (γc) is alymphoid because these receptors provide essential signals at the earliest stages of thymocyte development. The signals transduced by these receptors potentially regulate proliferation, survival, or differentiation, but the contribution of each receptor to distinct intracellular signaling cascades is only poorly defined. Here, we have examined whether enforced expression of Bcl-2 can rescue thymocyte development in c-kit and γc single or double mutant mice. A bcl-2 transgene (Eμ-bcl-2-25; expressed in the T cell lineage) was introduced into (a) c-kit and γc wild-type (c-kit+γc +bcl+), (b) c-kit–deficient (c-kit−γc +bcl+), (c) γc-deficient (c-kit+γc −bcl+), or (d) c-kit and γc double-deficient mice (c-kit−γc −bcl+). The bcl-2 transgene was functionally active in wild-type and c-kit or γc single mutants, as it promoted survival of ex vivo isolated thymocytes, including pro-T cells. In vivo, however, transgenic Bcl-2 did not release T cell precursors from their phenotypic block and failed to increase progenitor or total thymocyte cellularity in c-kit or γc single or double mutants. These data argue strongly against a role for Bcl-2 as a key mediator in signaling pathways linked to cytokine and growth factor receptors driving early thymocyte development.
On extending quantum behaved particle swarm optimization to multiobjective context

Quantum behaved particle swarm optimization (QPSO) is a recently proposed metaheuristic, which describes bird flocking trajectories by a quantum behavior. It uses only one tunable parameter and suggests a new and interesting philosophy for moving in the search space. It has been successfully applied to several problems. In this paper, we investigate the possibility of extending QPSO to handle multiple objectives. More specifically, we address the way global best solutions are recorded within an archive and used to compute the local attractor point of each particle. For this purpose, a two level selection strategy that uses sigma values and crowding distance information has been defined in order to select the suitable guide for each particle. The rational is to help convergence of each particle using sigma values while favoring less crowded regions in the objective space to attain a uniformly spread out Pareto front. The proposed approach has been assessed on test problems for function optimization from convergence and diversity points of view. Very competitive results have been achieved compared to some state of the art algorithms.
Excessive Internet use for Sexual Purposes Among Members of Sexaholics Anonymous and Sex Addicts Anonymous

ABSTRACT There is a debate about whether excessive internet use for sexual purposes should be considered a behavioral addiction. This qualitative study of 18 members (Mage = 37.22 years) of Sexaholics Anonymous and Sex Addicts Anonymous aimed to examine which symptoms were essential for treatment and how their phenomenological manifestations corresponded to the criteria of behavioral addiction. The study participants did not explicitly deal with tolerance and withdrawal symptoms. However, addressing the remaining criteria of addiction was the core of the recovery process, suggesting that in some persons it is relevant to treat this behavior as a behavioral addiction.
Etiology of Thrombocytosis in a General Medicine Population: Analysis of 801 Cases With Emphasis on Infectious Causes

Background The clinical importance of an elevated platelet count is often overlooked, particularly as a diagnostic clue to the presence of an underlying infection. We sought to better describe the relationship between thrombocytosis and inflammatory conditions, with a focus on infectious causes. Methods We retrospectively reviewed 801 sequential cases of thrombocytosis (platelet count > 500 × 109/L) at a tertiary care hospital. Results Essential thrombocythemia was the most common cause of primary thrombocytosis, and these patients were more likely to have extreme (> 800 × 109/L) and prolonged (> 1 month) thrombocytosis. Secondary thrombocytosis was more common than primary, with infectious causes accounting for nearly half the cases. Demographic factors associated with an infectious etiology included inpatient status, quadriplegia/paraplegia, an indwelling prosthesis, dementia and diabetes. Clinical and laboratory characteristics associated with an infectious cause of thrombocytosis included fever, tachycardia, weight loss, hypoalbuminemia, neutrophilia, leukocytosis and anemia. Patients with thrombocytosis secondary to infection had a more rapid normalization of platelet count, but higher risk of dying, than those with secondary, non-infectious causes. Conclusions Infection is a common cause of thrombocytosis and should be considered in patients with comorbidities that increase risk of infection and when clinical and/or laboratory data support an infectious etiology. Thrombocytosis may have prognostic implications as a clinical parameter.
A novel phosphodiesterase type 4 inhibitor, YM976 (4-(3-chlorophenyl)-1,7-diethylpyrido[2,3-d]pyrimidin-2(1H)-one), with little emetogenic activity.

We synthesized a novel phosphodiesterase type 4 (PDE4) inhibitor, YM976, that is structurally different from the other PDE4 inhibitors like rolipram. In the present study, the pharmacological profile of YM976 was investigated. YM976 exhibited a strong and competitive inhibition against PDE4 purified from human peripheral leukocytes with an IC(50) of 2.2 nM. IC(50) values of rolipram and RP73401 were 820 and 0.43 nM, respectively. Test compounds had no effects on the other PDE isozymes, PDE1, -2, -3, and -5. YM976 potentiated prostaglandin E(2)-induced cAMP accumulation in a human mononuclear cell line, U937, and inhibited tumor necrosis factor-alpha production from human peripheral blood mononuclear cells stimulated by lipopolysaccharide. Anti-inflammatory activities of PDE4 inhibitors were compared in rat carrageenan-induced pleurisy models. YM976, rolipram, and RP73401 inhibited the cell infiltration into the pleural cavity with oral ED(30) values of 9.1, 10, and 7.4 mg/kg, respectively. YM976 produced no emesis up to 10 mg/kg, whereas rolipram and RP73401 induced emesis at oral doses of 3 mg/kg. To evidence the dissociation of anti-inflammatory activity from emesis, the anti-inflammatory effect of YM976 was examined in ferrets. YM976 dose dependently reduced carrageenan-induced leukocyte infiltration at the doses of 1, 3, and 10 mg/kg, p.o. On the other hand, rolipram failed to show obvious inhibition at doses that do not induce emesis. In conclusion, YM976 is a novel and orally active PDE4 inhibitor and possesses a good separation of emetogenicity from anti-inflammatory activity.
Assessment of Clinical and Laboratory Variables as a Guide to Packed Red Blood Cell Transfusion of Euvolemic Anemic Dogs

Background There are no standardized guidelines for determining the likelihood that euvolemic anemic dogs will benefit from transfusion of packed red blood cells (pRBC). Objectives To report clinical and laboratory variables of dogs receiving pRBC transfusion, which could guide transfusion of other anemic dogs. Animals Twenty‐four client‐owned anemic dogs receiving pRBC transfusion. Methods Prospective study; 30 transfusions assessed. Clinical findings (mucosal color, pulse quality, heart rate, respiratory rate, mentation/exercise tolerance) before and after transfusion were evaluated by the anemic dog clinical assessment score (ADCAS). Hemoglobin concentration, hematocrit, venous oxygen content (CvO2), and lactate concentration were measured from blood samples taken before and after transfusion. These results were not used for case management. Results All ADCAS variables decreased significantly with transfusion (P < .001); the total score was ≥5/12 before transfusion, and ≤3/12 in all cases that were deemed to no longer require transfusion. Hematocrit and CvO2 were <17% and <5 mL/dL, respectively, in 83% of cases before transfusion and hemoglobin concentration was <5.8 g/dL in 80%. Hemoglobin concentration, hematocrit, and CvO2 increased significantly with transfusion (P < .001); lactate concentration decreased significantly (P = .006). Conclusions and Clinical Importance Clinical and laboratory variables improved significantly after transfusion of pRBC. By identifying how transfusion affected these variables, it was possible to recognize clinical (ADCAS) and laboratory (hemoglobin, CvO2, lactate) variables, which could be useful in guiding the decision to transfuse dogs with similar presentations.
Altered localization of HrpZ in Pseudomonas syringae pv. syringae hrp mutants suggests that different components of the type III secretion pathway control protein translocation across the inner and outer membranes of gram-negative bacteria

Pseudomonas syringae pv. syringae 61 (Pss61) secretes the HrpZ harpin by a type III protein secretion pathway encoded by a cluster of hrp (hypersensitive response and pathogenicity) and hrc genes. The nine hrc genes represent a subset of hrp genes that are also conserved in the type III virulence protein secretion systems of animal pathogenic Yersinia, Shigella, and Salmonella spp. The hrpJ and hrpU operons contain seven hrc genes (counting hrcQ(A) and hrcQ(B) as one gene), all with additional homologs involved in flagellar biogenesis and secretion, and five of which encode predicted inner membrane proteins. The hrpC and hrpZ operons encode HrcC and HrcJ, respectively, which are associated with the outer membrane. Interposon mutants affected in all of the hrc genes in the hrpJ and hrpU operons and TnphoA-induced hrcC and hrcJ mutants were assayed for altered localization of HrpZ in mid-log-phase cultures by immunoblotting sodium dodecyl sulfate-polyacrylamide gels that were run with various cell fractions. The hrpJ and hrpU operon mutants revealed a novel phenotype of partially reduced accumulation of HrpZ in the total culture (despite wild-type levels of hrpZ operon transcription), all of which was cell bound and equivalent in level to that of cell-bound HrpZ in the wild type. The hrcC and hrcJ mutant cultures accumulated the same total amount of HrpZ as the wild type, but the HrpZ was cell bound. Among all the strains tested, only the hrcC mutant accumulated significant amounts of HrpZ in the periplasm, as indicated by selective release through spheroplasting. Analysis of nonpolar mutations in the hrpU and hrpC operons support the results obtained with polar mutations. These observations indicate that a constant pool of HrpZ is maintained in the cytoplasm of Pss61 despite secretion deficiencies, that the hrpJ and hrpU operons encode an alternative to the Sec (general protein export) pathway for translocation across the inner membrane, that genes in the hrpC operon are necessary for translocation across the outer membrane, and that the Pss61 Hrp system permits study of two genetically distinguishable stages in type III protein secretion.
In vivo monitoring of collagen-sponge remodeling using MRI

5 1. Nuclear Magnetic Resonance – An Introduction 6 1.1 Basic Physics 6 1.1.1 Magnetic Dipole Moment 6 1.1.2 Spin Angular Momentum 7 1.2 Magnetic Resonance 8 1.2.1 Energy States 8 1.2.2 Boltzmann Distribution 9 1.2.3 Larmor Frequency 9 1.2.4 Free Induction Decay 10 1.3 MRI Parameters 11 1.3.1 Spin-Spin Relaxation Time (T2) 11 1.3.2 Spin-Lattice Relaxation Time (T1) 13 1.3.3 Effect of MRI Contrast Agents on T1 and T2 Relaxation Times 14 1.4 Imaging Techniques 16 1.4.1 Gradient Coils and k-Space 16 1.4.2 Water Apparent Diffusion Coefficient (ADC) 17 1.5 Pulse Sequences 19 1.5. 1 Spin Echo 19 1.5. 2 Hahn Spin-Echo (HSE) 20 1.5. 3 Carr-Purcell-Meiboom-Gill (CPMG) 21 1.6 Surface coils 22 2. Introduction to Biomaterials and Applications 24 2.1 Background 26 2.1.1 Sponge Manufacturing 26 2.1.2 Pore Structure 27 2.1.3 Crosslinking 27 2.1.4 Carbodiimides 28 2.1.5 Glycosaminoglycans 28 3 2.2 In vivo Implantation 29 2.2.1 Physiological Outcomes 30 2.2.2 Inflammatory Response and Cell Infiltration 30 2.2.3 Angiogenesis 31 2.2.4 Biodegradation 31 2.2. 5 Capsule Formation 32 2.3 Histology 32 2.4 Hypotheses 33 3. Materials and Methods 35 3.1 Sponges Preparation 35 3.2 Animal Preparation 36 3.3 MRI Measurements 38 3.4 Data Analysis 40 3.5 Histological Analysis 41 3.6 Statistical Analysis 42 3.6. 1. Student’s T-test 42 3.6. 2. Bonferroni Corrections 42 4. Results 44 4.1 Remodeling and Tissue responses 44 4.1.2 Day 2 44 4.1.3 Day 7 46 4.1.4 Day 14 47 4.1.5 Day 21 48 4.1.6 Day 28 50 4.1. 7 Day 35 51 4.1. 8 Day 42 52 4.2 Volume Changes for EDC+CS Sponges as a Function of Implantation Time 53 4.3 Changes in T2 Values in EDC+CS as a Function of Implantation Time 55 4.4 Changes in Water Apparent Diffusion Coefficient (ADC) Values in EDC+CS Sponges as a Function of Implantation Time 56
PKM2 Subcellular Localization Is Involved in Oxaliplatin Resistance Acquisition in HT29 Human Colorectal Cancer Cell Lines

Chemoresistance is the main cause of treatment failure in advanced colorectal cancer (CRC). However, molecular mechanisms underlying this phenomenon remain to be elucidated. In a previous work we identified low levels of PKM2 as a putative oxaliplatin-resistance marker in HT29 CRC cell lines and also in patients. In order to assess how PKM2 influences oxaliplatin response in CRC cells, we silenced PKM2 using specific siRNAs in HT29, SW480 and HCT116 cells. MTT test demonstrated that PKM2 silencing induced resistance in HT29 and SW480 cells and sensitivity in HCT116 cells. Same experiments in isogenic HCT116 p53 null cells and double silencing of p53 and PKM2 in HT29 cells failed to show an influence of p53. By using trypan blue stain and FITC-Annexin V/PI tests we detected that PKM2 knockdown was associated with an increase in cell viability but not with a decrease in apoptosis activation in HT29 cells. Fluorescence microscopy revealed PKM2 nuclear translocation in response to oxaliplatin in HCT116 and HT29 cells but not in OXA-resistant HTOXAR3 cells. Finally, by using a qPCR Array we demonstrated that oxaliplatin and PKM2 silencing altered cell death gene expression patterns including those of BMF, which was significantly increased in HT29 cells in response to oxaliplatin, in a dose and time-dependent manner, but not in siPKM2-HT29 and HTOXAR3 cells. BMF gene silencing in HT29 cells lead to a decrease in oxaliplatin-induced cell death. In conclusion, our data report new non-glycolytic roles of PKM2 in response to genotoxic damage and proposes BMF as a possible target gene of PKM2 to be involved in oxaliplatin response and resistance in CRC cells.