Miracle-dz/UniFAR-FTUs huggingface dataset:
Development and evaluation of a Spanish-language version of the Relational Health Indices.

We reported the development and evaluation of a Spanish-language version of the Relational Health Indices (RHI; Liang et al., 2002) for use in clinical and research settings. Participants were 348 men and women from international (n = 201) and domestic (n = 147) locations who were heritage Spanish speakers. A multistage translation of the RHI is described as well as the procedure used to evaluate the internal structure of the translated assessment. The results indicated a modest 3-factor structure, χ2(628) = 1397.16, p < . 001; comparative fit index (CFI) = . 86, Tucker-Lewis index (TLI) = . 85, root mean square error of approximation (RMSEA) = . 06 for the amigo (peer), mentor (mentor), and comunidad (community) subscales that has practical implications for treatment planning, outcome evaluation, and program development. Implications for counseling practice and future research are discussed. (PsycINFO Database Record
ExACtly zero or once

Objective: To assist the interpretation of genomic data for common epilepsies, we asked whether variants implicated in mild epilepsies in autosomal dominant families are present in the general population. Methods: We studied 12 genes for the milder epilepsies and identified published variants with strong segregation support (de novo germline mutation or ≥4 affected family members). These variants were checked in the Exome Aggregation Consortium (ExAC), a database of genetic variation in over 60,000 individuals. We subsequently evaluated variants in these epilepsy genes that lacked strong segregation support. To determine whether the findings in epilepsies were representative of other diseases, we also assessed the presence of variants in other dominant neurologic disorders (e.g., CADASIL). Results: Published epilepsy variants with strong segregation support (n = 65) were absent (n = 61) or present once (n = 4) in ExAC. By contrast, of 46 published epilepsy variants without strong segregation support, 8 occurred recurrently (2–186 times). Similarly, none of the 45 disease-associated variants from other neurologic disorders with strong segregation support occurred more than once in ExAC. Reanalysis using the larger ExAC V2 plus gnomAD reference cohort showed consistent results. Conclusions: Variants causing autosomal dominant epilepsies are ultra-rare in the general population. Variants observed more than once in ExAC were only found among reports without strong segregation support, suggesting that they may be benign. Clinicians are increasingly faced with the interpretation of genetic variants of unknown significance. These data illustrate that variants present more than once in ExAC are less likely to be pathogenic, reinforcing the valuable clinical role of ExAC.
The cat flea, Ctenocephalides felis felis (Bouché, 1835) as an intermediate host for cestodes

The growth and development of Dipylidium caninum, Hymenolepis citelli, H. diminuta, H. microstoma, and H. nana were examined in Ctenocephalides felis, and the Hymenolepis species further examined in the reference host Tribolium confusum. This is the first recorded infection of C. felis with these four species of Hymenolepis and also of a flea with H. citelli. Growth and development of the four species of Hymenolepis were comparable in C. felis and T. confusum. Observations relative to scolex formation indicated that perhaps only one basic sequence occurs in the genus Hymenolepis. Growth and metamorphosis of the flea host had no important effects upon Hymenolepis development. However, presumably owing to greater crowding in C. felis than in T. confusum, an increased amount of retarded development was noted in cestodes from fleas. In contrast, the growth and metamorphosis of the flea host did affect the development of D. caninum. Little growth occurred in larval fleas but with the onset of pupation an increased growth rate was initiated, the cestode reaching almost its maximum size prior to the emergence of the adult flea. Cysticercoid differentiation and maturation mostly occurred within the adult.
Delayed reentry of recycling vesicles into the fusion-competent synaptic vesicle pool in synaptojanin 1 knockout mice

Synaptojanin 1 is a polyphosphoinositide phosphatase implicated in synaptic vesicle recycling. We used FM1-43 imaging and electron microscopy in cultured cortical neurons from control and synaptojanin 1 knockout mice to study how the absence of this protein affects specific steps of the synaptic vesicle cycle. Exo/endocytosis after a moderate stimulus was unchanged. However, during prolonged stimulation, the regeneration of fusion-competent synaptic vesicles was severely impaired. In stimulated nerve terminals, there was a persistent accumulation of clathrin-coated vesicles and a backup of newly reformed vesicles in the cytomatrix-rich area around the synaptic vesicle cluster. These findings demonstrate that synaptojanin 1 function is needed for the progression of recycling vesicles to the functional synaptic vesicle pool.
LY α TRANSFER IN A THICK, DUSTY, AND STATIC MEDIUM

We developed a Monte Carlo code that describes the resonant Ly line transfer in an optically thick, dusty, and static medium. The code was tested against the analytic solution derived by Neufeld (1990). We explain the line transfer mechanism by tracing histories of photons in the medium. We find that photons experiences a series of wing scatterings at the moment of thier escape from the medium, during which polarization may develop. We examined the amount of dust extinction for a wide range of dust abundances, which are compared with the analytic solution. Brief discussions on the astrophysical application of our work are presented.
Deconstructing the Pioneer's Advantage: Examining Vintage Effects and Consumer Valuations of Quality and Variety

Several studies have demonstrated an order-of-entry effect on market share, suggesting that pioneers outperform later entrants. However, other research has pointed out the limitations of these studies and found evidence that many pioneers fail or have low market share. Given this background, the purpose of this research is to understand the conditions under which pioneers are more likely and also less likely to have an advantage. We propose a game-theoretic model that includes important sources of pioneer advantages as well as disadvantages. Specifically, we incorporate a pioneer advantage due to preemption in markets with heterogeneous tastes. In addition, we incorporate a potential pioneer disadvantage due to technology vintage effects, where later entrants utilizing improved technology can have lower costs and higher quality. The model allows us to evaluate the extent of vintage effects necessary to overcome a pioneer's advantage. Key relationships are found between the magnitude of the pioneer advantage or disadvantage and consumer valuations of product attributes (e.g., variety and quality). We empirically validate the model with vintage effect data in 36 product categories, and measures of consumer valuations of product variety and quality for 12 of these 36 categories. The results show that pioneers do better in product categories wherevariety is more important and worse in categories where productquality is more important. Pioneers in categories with high vintage effects are shown to have lower market shares and higher failure rates. Similar results appear when analyzing persistence of market leadership over time, further validating our model's major implications. We also present two case studies that illustrate key elements of the model.
[Ureaplasma urealyticum infection in the genital tract reduces seminal quality in infertile men].

OBJECTIVE To understand Ureaplasma urealyticum (Uu) infection, analyzed the influence of Uu infection on the seminal quality and the accessory genetical gland function in male infertility patients, and investigate its mechanism. METHODS We cultured 202 semen samples collected from male infertility patients and analyzed the influence of Uu infection on seminal parameters and the biochemical indexes of the seminal plasma. RESULTS The Uu infection rate was 33.7% in the infertile males, with no statistic differences between the Uu positive and negative groups either in the average age (28.9 +/- 4.7 yrs vs 29.6 +/- 4.0 yrs, P = 0.250) or in the seminal quantity (2.93 +/- 1.32 ml vs 2.86 +/- 1.52 ml, P = 0.774). The sperm density, motility and vitality were (84.37 +/- 52.92) x 10(6) ml, (44.62 +/-22.13) % and (38.40 +/- 15.61) % in the Uu positive group, significantly lower than (101.90 +/- 43.90) x 10(6) ml, (51.83 +/- 19.88) % and (44.45 +/- 15.47) % in the Uu negative group (P = 0.025, P = 0.036 and P = 0.020). The seminal pH value was normal in both of the groups, but significantly higher in the Uu positive than in the negative group (7.32 +/- 0.10 vs 7.19 +/- 0.29, P = 0.003). VCL, VSL, VAP and MAD were significantly lower, while BCF was significant higher in the former than in the latter [(33.97 +/- 8.96) microm/s vs (39.70 +/- 8.14) microm/s, t = 4.113, P < 0.001; (22.29 +/- 6.06) microm/s vs (25.20 +/- 6.67) microm/s, t = 2.684, P = 0.008; (25.96 +/- 6.83) microm/s vs (30.02 +/- 6.81) microm/s, t = 3.537, P < 0.001; 46.60 +/- 13.68 vs 54.23 +/- 15.14, t = 3.112, P = 0.002; (6.12 +/- 1.89) Hz vs (5.22 +/- 1.64) Hz, t = 3. 164, P = 0.002]. All the five indexes were influenced by Uu infection. Compared with the negative group, the seminal plasma alpha-glucosidase was significantly decreased in the positive group [(40.0 +/-18.7) U/ml vs (47.9 +/- 21.0) U/ml, t = 2.248, P = 0.026], and the risk of the decrease was 2.12 times higher. No statistic difference was observed in seminal plasma acid phosphatase and seminal plasma fructose between the two groups. CONCLUSION Uu infection in the genital tract is an important factor of seminal quality reduction in infertile men and may cause a decreased secretion of alpha-glucosidase in the epididymis, but it hardly influences the prostate and seminal vesicle.
A High-Content Glucocorticoid Receptor Translocation Assay for Compound Mechanism-of-Action Evaluation

Ligand-induced cytoplasm to nucleus translocation is a critical event in the nuclear receptor (NR) signal transduction cascade. The development of green fluorescent proteins and their color variants fused with NRs, along with the recent developments in automated cellular imaging technologies, has provided unique tools to monitor and quantify the NR translocation events. These technology developments have important implications in the mechanistic evaluation of NR signaling and provide a powerful tool for drug discovery. The unique challenges for developing a robust NR translocation assay include cytotoxicity accompanied with chronic overexpression of NRs, basal translocation induced by serum present in culture medium, and interference from endogenous NRs, as well as subcellular dynamics. The authors have developed a robust assay system for the glucocorticoid receptor (GR) that was applied to a panel of nuclear receptor ligands. Using a high-content imaging system, ligand-induced, dose-dependent GR nuclear translocation was quantified and a correlation with other conventional assays established. (Journal of Biomolecular Screening 2007:1029-1041)
Effects of the Tumor Microenvironment on the Efficacy of Tumor Immunotherapy

Cancer immunotherapy utilizes vaccines targeting tumor antigens or tumor endothelium to prevent or regress tumors. Many cancer vaccines are designed to induce antigen-specific effector T cells that migrate to the tumor site. In an optimal situation, the effector T cells penetrate the tumor, release their effector molecules, induce tumor cell death and tumor regression. However, the tumor microenvironment is frequently immunosuppressive and contributes to a state of immune ignorance, impacting on the vaccine's ability to break tolerance to tumor antigen/s. This review discusses the factors in the tumor microenvironment that can affect the efficacy of cancer vaccines. In particular, the review focuses on pathways leading to effector T cell penetration of tumors or the inhibition of this process.
Gold(III)‐dithiocarbamato anticancer agents: Activity, toxicology and histopathological studies in rodents

Gold(III)‐dithiocarbamato complexes have recently gained increasing attention as potential anticancer agents because of their strong tumor cell growth–inhibitory effects, generally achieved by exploiting non‐cisplatin‐like mechanisms of action. The rationale of our research work is to combine the antitumor properties of the gold(III) metal center with the potential chemoprotective function of coordinated dithiocarbamates in order to reduce toxic side effects (in particular nephrotoxicity) induced by clinically established platinum‐based drugs. In this context, [AuIIIBr2(ESDT)] (AUL12) was proved to exert promising and outstanding antitumor activity in vitro and to overcome both acquired and intrinsic resistance showed by some types of tumors toward cisplatin. As a subsequent extension of our previous work, we here report on detailed in vivo studies in rodents, including antitumor activity toward three transplantable murine tumor models, toxicity, nephrotoxicity and histopathological investigations. Remarkably, the gold(III) complex AUL12 stands out for higher anticancer activity than cisplatin toward all the murine tumor models examined, inducing up to 80% inhibition of tumor growth. In addition, it shows low acute toxicity levels (lethal dose, LD50 = 30 mg kg−1) and reduced nephrotoxicity. Altogether, these results confirm the reliability of our drug design strategy and support the validation of this gold(III)‐dithiocarbamato derivative as a suitable candidate for clinical trials.
Two women filmmakers remember the dark years

Abstract This article examines Diane Kurys's Entre Nous (1983) and Chantai Akerman's Les Rendez‐vous d'Anna (1978) and Window Shopping (1986). Born after the war years, both filmmakers use an autobiographical persona who ‘remembers’ the war through the memories of a parental generation, particularly through the mother. In both films, history is inscribed, firstly, in relationships that are represented as the consequence of catastrophe; secondly, in persistent themes and motifs heavy with historical significance; and thirdly, in the very structure of the filmic narration. Akerman is the more experimental of the two directors and constructs a postwar trans‐European identity. Yet both use female bonding and lesbianism to help clarify how the war is remembered.
Factors associated with late diagnosis of cervical cancer in Nepal.

BACKGROUND The majority of cervical cancers, the most prevalent cancer among Nepali women, are diagnosed in advanced stage leading to high mortality in Nepal. The present study explored factors associated with late diagnosis. MATERIALS AND METHODS A cross-sectional study was carried out in two specialized cancer hospitals of Nepal from August 12 to October 12, 2012. Randomly selected 110 cervical cancer patients were interviewed and their medical records were reviewed. Multivariate logistic regression analysis was performed to predict associations. RESULTS Mean age of patients was 52.7years (SD=10.6), 66% were illiterate and 77% were rural inhabitants. Medical shops (33.6%) and private hospitals (31%) were major first contact points of patients with health care providers (HCP). There was no cervical/per-speculum examination (78.2%) and symptoms misinterpretation (90%) of patients occurred in initial consultation with HCP. Four in every five cases (80.9%) of cervical cancer had late diagnosis. Literate women (adjusted OR=0.121, CI: 0.030-0.482) and women having abnormal vaginal bleeding as early symptom (adjusted OR=0.160, CI: 0.035-0.741) were less likely to suffer late diagnosis. Women who shared their symptoms late (adjusted OR=4.272, CI: 1.110-16.440) and did so with people other than their husband (adjusted OR=12.701, CI: 1.132-142.55) were more likely for late diagnosis. CONCLUSIONS High level of illiteracy among women and their problematic health seeking behavior for gynecological symptoms are responsible for late diagnosis of cervical cancer in Nepal. In the absence of a routine screening program, prevention interventions should be focused on raising awareness of gynecological symptoms and improving health seeking behavior of women for such symptoms.
Jua Cali, genge rap music and the anxieties of living in the glocalized city of Nairobi

ABSTRACT This article seeks to track the emergence of a rap genre dubbed genge, which is rendered in sheng, a type of urban slang, which is a mixture of Swahili, English and other local dialects. Positioning genge within the milieu of cultural expressions that give voice to marginalized urban youths, the article examines how several genge rappers appropriate urban spaces and delineate them as sites of masculine domination, contestation and urban cosmopolitanism within the larger glocal imaginary desires. My analysis makes use of examples from lyrics of songs performed by various artists such as Jua Cali, Nonini and a host of others, to illustrate how their deployment of poetic lyricism romanticizes city spaces (especially in Nairobi, the capital of Kenya) as melting pots of masculine fears, tensions and anxieties.
Where does blood go? Prospective observational study of red cell transfusion in north England

Abstract Objective: To collect population based information on transfusion of red blood cells. Design: Prospective observational study over 28days. Setting: Hospital blood banks in the north of England (population 2.9million). Main outcome measures: Indications for transfusion, number of units given, and the age and sex of transfusion recipients. Participants: All patients who received a red cell transfusion during the study period. Data completed by hospital blood bank staff. Results: The destination of 9848 units was recorded (97% of expected blood use). In total 9774 units were transfused: 5047 (51.6%) units were given to medical patients, 3982 (40.7%) to surgical patients, and 612 (6.3%) to obstetric and gynaecology patients. Nearly half (49.3%) of all blood is given to female recipients, and the mean age of recipients of individual units was 62.7 years. The most common surgical indications for transfusion were total hip replacement (4.6% of all blood transfused) and coronary artery bypass grafting (4.1%). Haematological disorders accounted for 15.5% of use. Overall use was 4274 units per 100 000 population per year. Conclusion: In the north east of England more than half of red cell units are transfused for medical indications. Demand for red cell transfusion increases with age. With anticipated changes in the age structure of the population the demand for blood will increase by 4.9% by 2008.
The gene encoding atrial natriuretic peptide and the risk of human stroke.

BACKGROUND Recent evidence from an animal model of stroke, the stroke-prone spontaneously hypertensive rat, implicated the gene encoding atrial natriuretic peptide (ANP) as a possible candidate contributing to the likelihood of experiencing a stroke. The purpose of the present study was to investigate the role of ANP in the pathogenesis of cerebrovascular accidents in humans. METHODS AND RESULTS We investigated 2 previously known markers at ANP, G1837A and T2238C, for their possible association with the occurrence of stroke. This was the largest matched case-controlled sample studied thus far; the sample was drawn from a large prospective study (the Physician's Health Study). When assuming a dominant mode of inheritance, a statistically significant positive association was observed for the 1837A allele, indicating an odds ratio of 1.64 (95% confidence interval, 1.01 to 2.65) for stroke. This observation led to the discovery of a new molecular variant in exon 1, G664A, which was responsible for a valine-to-methionine substitution in the proANP peptide. This mutation, which was in linkage disequilibrium with the G1837A marker, was associated with the occurrence of stroke (odds ratio, 2.0; 95% confidence interval, 1.17 to 3.19; P=0.01). CONCLUSIONS Our findings suggest that molecular variants of the ANP gene may represent an independent risk factor for cerebrovascular accidents in humans. The strong parallelism to the experimental data obtained in the stroke-prone animal model provides assurance for the relevance of our observation.
Foundations of Financial Well-Being: Insights into the Role of Executive Function, Financial Socialization, and Experience-Based Learning in Childhood and Youth

type="main" xml:id="joca12068-abs-0001"> During childhood and youth we build the foundations for financial well-being later in life, acquiring the knowledge, skills, attitudes, and personality traits that enable us to manage our finances as adults. This article reviews literature from consumer science, developmental psychology, and allied fields to gain insight into moments during youthful development when interventions are likely to have greatest impact. We find promising avenues for influence during each developmental life stage. Many present truly novel approaches to financial education—such as focusing on improving executive function in young children (critical despite lacking apparent “financial content”), emphasizing financial attitude development through dual-generation financial modeling for elementary and middle school students and their parents, or intentionally teaching financial heuristics and other practical skills to later adolescents and young adults. Overall, this article proposes a range of innovative strategies to improve financial education, from early childhood through young adulthood.
Not Wanted in the Inbox!: Evaluations of Unsolicited and Harassing E-Mail1

This study was designed as a first step to explore sexual harassment in the electronic domain. One hundred six students read 10 e-mail messages ranging from jokes to spam to a sexual proposition from a stranger and rated them on an offensiveness evaluative scale. Participants also completed social desirability and attitudes toward sexual harassment scales. Messages with sexual content were generally perceived less favourably than e-mail without such content. Gender was critical to the experience of receiving many types of e-mail messages. When the e-mail content was perceived to be offensive, women found it more offensive than did men. Marked gender differences emerged in response to the sexual proposition, which women perceived to be extremely offensive while men rated it as somewhat enjoyable. Tolerance of sexual harassment and familiarity with a type of e-mail were also related to lower offensiveness evaluations for some messages.