Miracle-dz/UniFAR-FTUs huggingface dataset:
Investigation of Notch Shear Cutting for JIS SCM420 Steel Wire Rod

This paper aims to study the notch shear cutting of JIS SCM420 steel wire rod. In the notch shear cutting experiment, the wire rod specimens were initially notched on the surfaces using a sharp insert installed at a lathe turning machine. Then, the specimens were cut off using the punch/die shearing tool. After the shear cutting, the sheared edge features of the wire rod were investigated and compared with the results obtained from the conventional shear cutting. In addition, the geometry of the notch, the notch depth, was varied ranging from approximately 333 to 537 μm and studied. The experimental results revealed that the cutting load resistance significantly decreased with the notch shear cutting technique. The roll over and the size of the burr zones also decreased, compared to the conventional shear cutting. This technique also improved the quality of the sheared edge in term of the roundness of the wire rod. Concerning the notch depth, it was a primary factor affecting the cutting results, especially the cutting load resistance and the occurrence of the long burr protruded from the surface of the wire rod. The improvement of the sheared edge quality by the notch shear cutting seemed to be caused by the suppression of the plastic deformation of the wire rod during shearing.
Adult acute lymphoblastic leukemia: a multicentric randomized trial testing bone marrow transplantation as postremission therapy. The French Group on Therapy for Adult Acute Lymphoblastic Leukemia.

PURPOSE In a prospective multicenter study, we analyzed the benefits of allogeneic bone marrow transplantation (BMT) in a nonselected group of adult patients with acute lymphoblastic leukemia (ALL) and, by a randomized trial, evaluated the effectiveness of autologous BMT over chemotherapy as postremission therapy in patients younger than 50 years who were not candidates for allogeneic BMT. PATIENTS AND METHODS After induction therapy that randomized patients to receive one of two anthracycline-containing regimens, either daunorubicin (DNR) or zorubicin (ZRB), patients were assigned to postremission treatment according to age and results of HLA typing. Patients younger than 40 years with an HLA-identical sibling (group 1) were scheduled to receive cyclophosphamide 60 mg/kg on days 1 and 2, total-body irradiation (TBI), and allogeneic BMT. Patients older than 50 years (group 2) received the chemotherapy arm composed of three monthly consolidation courses (DNR or ZRB, cytarabine, and asparaginase) followed by maintenance chemotherapy (modified L10 regimen). The remaining population (group 3) was randomly assigned to receive, after the three 1-month consolidation courses, either the chemotherapy arm or autologous BMT following a conditioning regimen similar to that of group 1. RESULTS Of the 572 assessable patients, 436 achieved complete remission (78% +/- 2% for DNR v 74% +/- 3% for ZRB; P = .3). The estimated 3-year disease-free survival (DFS) rate for the 116 patients included in group 1 was 43% +/- 5%. Both autologous BMT (95 patients) and chemotherapy (96 patients) produced comparable 3-year DFS rates (39% +/- 5% v 32% +/- 5%) and survival durations (49% +/- 5% v 42% +/- 5%). However, late relapses after 36 months were mainly observed in the chemotherapy arm. CONCLUSION This first interim analysis did not demonstrate a benefit of this autologous BMT procedure over classical maintenance chemotherapy in patients with ALL who received consolidation chemotherapy.
Melatonin Concentrations and Antioxidative Capacity of Human Breast Milk According to Gestational Age and the Time of Day

Background: While changes in the composition of breast milk throughout the lactation period are well known, little is known about the antioxidative capacity of breast milk and its regulation as a function of time of day. Objective: The aim of this study was to evaluate the antioxidative capacity in breast milk and its regulation by time of day. Methods: Melatonin, superoxide dismutase (SOD), glutathione peroxidase 3 (Gpx3) concentrations, and the total antioxidative capacity (TAOC) were analyzed in 105 breast milk samples and 12 maternal serum samples from 21 healthy nursing mothers. Results: Comparison between daytime breast milk (collected from 1000-2200 h) and nighttime breast milk (collected from 2200-1000 h) revealed significantly higher concentrations of melatonin and Gpx3 in nighttime milk (melatonin: 1.5 pg/mL [1.0-2.1] day vs 7.3 pg/mL [3.8-13.6] night, median [quartiles], with an estimated mean night-to-day ratio of 5.2 [3.9, 7.1], P < .001; Gpx3: 1436 ng/mL [765-2060] day vs 1800 ng/mL [1242-2297] night, night-to-day difference 192.1 [0.6, 383.7], P = .049). Subgroup analysis showed that melatonin had a circadian rhythm in both preterm and term milk, with a significantly higher nighttime concentration (P < .001), while antioxidant enzymes had a circadian rhythm only in preterm milk, with a significantly higher nighttime concentration for Gpx3 and a significant higher daytime concentration for SOD and TAOC (P = .041 and P = .049, respectively). We found no significant correlation between the concentration of melatonin and the concentration of SOD, Gpx3, or TAOC. Moreover, there were no significant correlations observed between gestational age and the concentration of melatonin and antioxidant enzymes. Conclusion: Because of its higher melatonin and Gpx3 content, future research is needed to determine if preterm nighttime milk ought to be the first choice in the feeding of high-risk preterm infants.
The scaling hypothesis: simplifying the prediction of network performance using scaled-down simulations

As the Internet grows, so do the complexity and computational requirements of network simulations. This leads either to unrealistic, or to prohibitely expensive simulation experiments.We explore a way to side-step this problem, by combining simulation with sampling and analysis. Our hypothesis is this: if we take a sample of the traffic, and feed it into a suitably scaled version of the system, we can extrapolate from the performance of the scaled system to that of the original.We find that when we scale a network which is shared by TCP-like flows, and which is controlled by a variety of active queue management schemes, then performance measures such as queueing delay and the distribution of flow transfer times are left virtually unchanged. Hence, the computational requirements of network simulations and the cost of experiments can decrease dramatically.
- 1-Breakdown of the FLT 3-ITD / STAT 5 axis and synergistic apoptosis induction by the histone deacetylase inhibitor Panobinostat and FLT 3-specific inhibitors

1 Institute of Biochemistry and Biophysics, Center for Molecular Biomedicine, Friedrich-Schiller University, 07745 Jena, Germany 2 Helmholtz Zentrum München / Klinikum Großhadern, KKG Leukämie, Marchioninistr. 25, 81377 München, Germany 10 3 Department of Medicine, Hematology/Oncology, Goethe University Frankfurt, Theodor-Stern-Kai 7, 60595 Frankfurt, Germany 4 Institute of Molecular Cell Biology, Center for Molecular Biomedicine, Jena University Hospital, 07745 Jena, Germany * Current address: Institute of Molecular Cancer Research, University of Zurich, 15 8057 Zurich, Switzerland
Effect of Storage on Physico-Chemical and Sensory Qualities of Commercial Fruit Beverages

Fruits and their value added products belong to an essential class of foods that supply human diet with nutritive requirements including vitamins and minerals which are essential for normal body health and function. They play important roles in the diet of most people in the tropics, providing essential minerals and vitamins and adding colour, flavour and variety to diet (Ragaert et al., 2004). Several reports have shown that adequate intake of fruits and vegetables form an important part of a healthy diet and low fruit and vegetable intake constitute a risk factor for chronic diseases such as cancer, coronary heart disease and cataract formation. In India among the various fruit based beverages, Ready-To-Serve (RTS) beverages ranks first followed by squash and syrup. Squash and syrups are non-alcoholic concentrated beverage that is usually fruitflavoured and made from fruit juice, water and sugar or a sugar substitute. Squash must be mixed with a certain amount of water or carbonated water before drinking. Fruit squash International Journal of Current Microbiology and Applied Sciences ISSN: 2319-7706 Volume 7 Number 10 (2018) Journal homepage: http://www.ijcmas. com
IMMUNOLOGIC STUDIES IN INSULIN RESISTANCE I. REPORT OF A CASE EXHIBITING VARIATIONS IN RESISTANCE AND ALLERGY TO INSULIN.

Extreme resistance to insulin has been reported in a small number of diabetic patients who, for varying periods, have tolerated ten to fifty times as much insulin as that commonly required for the control of diabetes. Even with these very large doses, control of the diabetic state has not always been achieved. The subject of resistance to insulin has been reviewed recently (1). The high tolerance exhibited by these patients has been tenatively ascribed to lack of some factor necessary for the action of insulin, to endocrine imbalance or abnormality, to allergy, or to a neutralizing antibody. Previous reports contained evidence for the presence of a neutralizing factor in the blood of an insulinresistant patient, which appeared to exhibit specificity and which was thought to be an antibody for insulin, distinct from the allergic antibody (2, 3). The course of this patient has now been followed for about 15 months and studies made during this period lend considerable support to the view that the resistance in this patient was immunologic in nature.
Acute osteomyelitis of the acetabulum induced by Staphylococcus capitis in a young athlete

Acute hematogenous osteomyelitis (AHOM) of the acetabulum is a rare condition in children and usually caused by Staphylococcus aureus. We present an 11-year-old soccer athlete who suffered from acute osteomyelitis involving the acetabulum caused by S. capitis, a normal flora of the human skin but never reported in this condition. The disease was associated with repetitive skin injuries of the knee and potential osseous microtrauma of the hip joint by frequent rigorous exercise. This unusual case suggests that osseous microtrauma of the acetabulum, in addition to repetitive skin injuries, allowed normal skin flora to colonize to the ipsilateral acetabulum, which served as a favorable niche and subsequently led to AHOM.
Structures in the fundamental plane of early‐type galaxies

The fundamental plane of early-type galaxies is a rather tight three-parameter correlation discovered more than twenty years ago. It has resisted a both global and precise physical interpretation despite a consequent number of works, observational, theoretical or using numerical simulations. It appears that its precise properties depend on the population of galaxies in study. Instead of selecting a priori these populations, we propose to objectively construct homologous populations from multivariate analyses. We have undertaken multivariate cluster and cladistic analyses of a sample of 56 low-redshift galaxy clusters containing 699 early-type galaxies, using four parameters: effective radius, velocity dispersion, surface brightness averaged over effective radius, and Mg2 index. All our analyses are consistent with seven groups that define separate regions on the global fundamental plane, not across its thickness. In fact, each group shows its own fundamental plane, which is more loosely defined for less diversified groups. We conclude that the global fundamental plane is not a bent surface, but made of a collection of several groups characterizing several fundamental planes with different thicknesses and orientations in the parameter space. Our diversification scenario probably indicates that the level of diversity is linked to the number and the nature of transforming events and that the fundamental plane is the result of several transforming events. We also show that our classification, not the fundamental planes, is universal within our redshift range (0.007 -- 0.053). We find that the three groups with the thinnest fundamental planes presumably formed through dissipative (wet) mergers. In one of them, this(ese) merger(s) must have been quite ancient because of the relatively low metallicity of its galaxies, Two of these groups have subsequently undergone dry mergers to increase their masses. In the k-space, the third one clearly occupies the region where bulges (of lenticular or spiral galaxies) lie and might also have formed through minor mergers and accretions. The two least diversified groups probably did not form by major mergers and must have been strongly affected by interactions, some of the gas in the objects of one of these groups having possibly been swept out. The interpretation, based on specific assembly histories of galaxies of our seven groups, shows that they are truly homologous. They were obtained directly from several observables, thus independently of any a priori classification. The diversification scenario relating these groups does not depend on models or numerical simulations, but is objectively provided by the cladistic analysis. Consequently, our classification is more easily compared to models and numerical simulations, and our work can be readily repeated with additional observables.
Observations of radar backscatter at Ku and C bands in the presence of large waves during the Surface Wave Dynamics Experiment

Ocean radar backscatter in the presence of large waves is investigated using data acquired with the Jet Propulsion Laboratory NUSCAT radar at Ku band for horizontal and vertical polarizations and the University of Massachusetts C-SCAT radar at C band for vertical polarization during the Surface Wave Dynamics Experiment. Off-nadir backscatter data of ocean surfaces were obtained in the presence of large waves with significant wave height up to 5.6 m. In moderate-wind cases, effects of large waves are not detectable within the measurement uncertainty and no noticeable correlation between backscatter coefficients and wave height is found. Under high-wave light-wind conditions, backscatter is enhanced significantly at large incidence angles,with a weaker effect at small incidence angles. Backscatter coefficients in the wind speed range under consideration are compared with SASS-II (Ku band), CMOD3-H1 (C band), and Plant's model results which confirm the experimental observations. Variations of the friction velocity, which can give rise to the observed backscatter behaviors in the presence of large waves, are presented. >
Dynamic load distribution in cooperative manipulation tasks

In cooperative manipulation tasks, load allocation is a crucial step in order to solve the intrinsic redundancy of the system. The desired wrench needs to be suitably distributed between the end-effectors to implement the desired motion of the manipulated object. In this framework, both the grasp kinematics and the individual capacities of each manipulator provide relevant constraints. On one hand, the end effector wrenches act on the object via the grasp geometry. On the other hand, the individual admissible payload further depends on the current configuration of the robots. In this paper we focus on a heterogeneous cooperative manipulation setting and we design a proper allocation strategy to distribute the desired object wrench, considering both constant and time-varying constraints for the load distribution. The relevance of our findings is illustrated by means of an experimental study involving two anthropomorphic robots manipulating a common object.
Influence of pH, precursor concentration, growth time, and temperature on the morphology of ZnO nanostructures grown by the hydrothermal method

We investigated the influence of the pH value, precursor concentration (C), growth time and temperature on the morphology of zinc oxide (ZnO) nanostructures. The pH of the starting solution was varied from1.8 to 12.5. It was found that the final pH reaches an inherent value of 6.6 independently of the initial pH solution. Various ZnO structures of nanotetrapod-like, flower-like, and urchin-like morphology were obtained at alkaline pH (8 to 12.5) whereas for pH solution lower than 8 rod-like nanostructures occurred. Moreover, we observed the erosion of the nanorods for a pH value less than 4.6. By changing the concentrations the density and size were also varied. On going from a high (C > 400mM) to lower (C < 25mM) C, the resulted ZnO nanostructures change from a film to nanorods (NRs) and finally nanowires (NWs). It was also found that the length and diameter of ZnO NRs follow a linear relation with time up to 10 hours, above which no further increase was observed. Finally the effect of growth temperature was seen as an influence on the aspect ratio.
Multiscale Behavior of Fused Deposition Additively Manufactured Thermoplastic Cellular Materials

ii Acknowledgements . iv List of Figures . viii List of Tables . x Chapter 1. Motivation of Additively Manufactured Cellular Materials . 1 Chapter 2. Literature Review . 5 2.1 Fused Deposition Additive Manufacturing . 5 2.2 Thermoplastics used in Fused Deposition Additive Manufacturing . 6 2.2.1 Poly (Lactic Acid) . 6 2.2.2 Acrylonitrile Butadiene Styrene . 6 2.3 Crazing . 7 2.3.1 Prediction of Micro Craze Initiation . 10 2.4 Cellular Materials. 11 Chapter 3. Phase 1: Global Properties and Local Mechanisms of Additively Manufactured Cellular Materials . 15 3.1. Methods and Materials . 15 3.2 Calculation of Effective Area . 17 3.2.1 Footprint Area . 18 3.2.2 Column Area . 18 3.2.3 Effective Area . 18 3.3. Results . 19 3.3.1 Honeycomb Cell Behavior . 20 3.3.2 Brick Cell Behavior . 23 3.4. Discussion . 25 3.4. 1 Comparison of Area Methods . 25 3.4. 2 Mechanical Behavior using the Effective Area Method . 27 3.5 Conclusions . 32
Impact of Preoperative Anemia on Outcome in Patients Undergoing Coronary Artery Bypass Graft Surgery

Background— The risk of preoperative anemia in patients undergoing heart surgery has not been described precisely. Specifically, the impact of low hemoglobin per se or combined with other risk factors on postoperative outcome is unknown. Thus, we determined the effects of low preoperative hemoglobin and comorbidities on postoperative adverse outcomes in patients with coronary artery bypass graft in a large comprehensive multicenter study. Methods and Results— The Multicenter Study of Perioperative Ischemia investigated 5065 patients with coronary artery bypass graft at 70 institutions worldwide, collecting ≈7500 data points per patient. In 4804 patients who received no preoperative transfusions, we determined the association between lowest preoperative hemoglobin levels and in-hospital cardiac and noncardiac morbidity and mortality and the impact of concomitant risk factors, assessed by EuroSCORE, on this effect. In patients with EuroSCORE <4 (n=2054), only noncardiac outcomes were increased, whereas patients with EuroSCORE ≥4 (n=2750) showed an increased incidence of all postoperative events, starting at hemoglobin <11 g/dL. Low preoperative hemoglobin was an independent predictor for noncardiac (renal>cerebral; P<0.001) outcomes, whereas the increase in cardiac events was due to other factors associated with preoperative anemia. Conclusions— Anemic patients undergoing cardiac surgery have an increased risk of postoperative adverse events. Importantly, the extent of preexisting comorbidities substantially affects perioperative anemia tolerance. Therefore, preoperative risk assessment and subsequent therapeutic strategies, such as blood transfusion, should take into account both the individual level of preoperative hemoglobin and the extent of concomitant risk factors.
Selective chloroform sensor using thiol functionalized reduced graphene oxide at room temperature

This paper presents a highly selective chloroform sensor using functionalised reduced graphene oxide (RGO) as a sensing layer. Thiol group is covalently attached on the basal plan of RGO film by a simple one-step aryl diazonium chemistry to improve its selectivity. Several spectroscopic techniques like X-ray photoelectron, Raman and Fourier transform infrared spectroscopy confirm successful thiol functionalization of RGO. Finally, the fabricated chemiresistor type sensor is exposed to chloroform in the concentration range 200–800 ppm (parts per million). The sensor shows a 4.3% of response towards 800 ppm chloroform. The selectivity of the sensor is analyzed using various volatile organic compounds as well. The devices show enhanced response and faster recovery attributed to the physiosorption of chloroform onto thiol functionalized graphene making them attractive for 2D materials based sensing applications.
Risk Factors for Death or Stroke After Carotid Endarterectomy: Observations From the Ontario Carotid Endarterectomy Registry

Background and Purpose— Carotid endarterectomy is an effective method for preventing strokes if patients do not suffer adverse perioperative outcomes. The purpose of this study was to identify preoperative patient risk factors for adverse outcomes (death or nonfatal stroke) after carotid endarterectomy through the use of a large population-based registry from Ontario, Canada. Methods— Medical records of all 6038 patients who underwent carotid endarterectomy in Ontario between January 1, 1994, and December 31, 1997, were abstracted from 34 hospitals. Patient characteristics (demographic data, past medical history, neurological symptoms, comorbidities, radiological findings) and 30-day postoperative death or stroke rates were analyzed with logistic regression analysis. Results— The overall 30-day death or stroke rate after surgery was 6.0%. A history of transient ischemic attack or stroke (odds ratio [OR], 1.75; 95% confidence interval [CI], 1.39 to 2.20), atrial fibrillation (OR, 1.89; 95% CI, 1.29 to 2.76), contralateral carotid occlusion (OR, 1.72; 95% C.I., 1.25 to 2.38), congestive heart failure (OR, 1.80; 95% CI, 1.15 to 2.81), and diabetes (OR, 1.28; 95% CI, 1.01 to 1.63) were significant independent predictors for 30-day death or stroke. These 5 factors were combined into a simple risk score that can be used to stratify patients into different risk groups for complications after surgery. Conclusions— Several patient characteristics predict the development of stroke and death after carotid endarterectomy. These characteristics may help clinicians in patient counseling and contribute to studies “benchmarking” the outcomes of carotid surgery in the community setting.