Miracle-dz/UniFAR-FTUs huggingface dataset:
Myelopoietic Efficacy of Orlistat in Murine Hosts Bearing T Cell Lymphoma: Implication in Macrophage Differentiation and Activation

Orlistat, an inhibitor of fatty acid synthase (FASN), acts as an antitumor agent by blocking de novo fatty acid synthesis of tumor cells. Although, myelopoiesis also depends on de novo fatty acid synthesis, the effect of orlistat on differentiation of macrophages, which play a central role in host’s antitumor defence, remains unexplored in a tumor-bearing host. Therefore, the present investigation was undertaken to examine the effect of orlistat administration on macrophage differentiation in a T cell lymphoma bearing host. Administration of orlistat (240 mg/kg/day/mice) to tumor-bearing mice resulted in a decline of tumor load accompanied by an augmentation of bone marrow cellularity and survival of bone marrow cells (BMC). The expression of apoptosis regulatory caspase-3, Bax and Bcl2 was modulated in the BMC of orlistat-administered tumor-bearing mice. Orlistat administration also resulted in an increase in serum level of IFN-γ along with decreased TGF-β and IL-10. BMC of orlistat-administered tumor-bearing mice showed augmented differentiation into macrophages accompanied by enhanced expression of macrophage colony stimulating factor (M-CSF) and its receptor (M-CSFR). The macrophages differentiated from BMC of orlistat-administered mice showed characteristic features of M1 macrophage phenotype confirmed by expression of CD11c, TLR-2, generation of reactive oxygen species, phagocytosis, tumor cell cytotoxicity, production of IL-1,TNF-α and nitric oxide. These novel findings indicate that orlistat could be useful to support myelopoesis in a tumor-bearing host.
Landscapes of shame in the church : a typology to inform ministerial praxis

This thesis answers the question How might an understanding of shame in the church inform approaches to ministerial praxis? It is methodologically a creative piece of practical theology which begins and ends with an autoethnographic reflection, drawing on the metaphor of landscape. The practical theology methodology involved the following stages: noticing; reflexivity; describing, naming; focusing; investigating; analysing; evaluating; theorizing, synthesizing; and responding, while drawing on insights from a mixed methods approach to qualitative research. The empirical research involved an anonymous online survey (261 respondents) to church leaders, church members and theological educators and two representative focus groups. Shame is defined phenomenologically using a range of disciplines; a review of literature relevant to shame and ministerial praxis is included. The unique contribution this thesis makes is twofold. Firstly, the development of an empirically underpinned typology of shame in the church which has six domains: personal, relational, communal, structural, theological and historical facilitating the identification of shame which is often a hidden phenomenon. Secondly, identifying specific approaches to ministerial praxis which help mitigate such shame including a shame examen to assist conscientization. The final chapter discusses the author’s learning about shame, ministerial praxis, doing theology and theological education.
Apparent lesbian performances, heteroflexibility and sexual identity: Fluid sexuality among young women in public places.

Semi-structured interviews were used to document the experiences of fifteen young women between the ages of 18-31 who have engaged in “apparent lesbian performances”. Apparent Lesbian behaviours occur when women engage in intimate behaviour with other women in public places. This study finds that women who engage in this behaviour may identify as lesbian, bisexual, or heterosexual. Their lesbian performativity is defined as “apparent” because it is characteristically not interpreted by the actors or their audience as the actions of “real” lesbians. Rather it is behaviour that has been encouraged and normalized by pop culture icons like Madonna and Britney Spears who have popularized the female kiss on TV in 1993. The notion of heteroflexibility and fluid sexuality is examined in relation to the many ways that the young women in this study used apparent lesbian performances to construct, test, maintain and understand their own sexual identity as both fluid and fixed. The performances take place within highly specific public contexts where apparent lesbian behaviours are accepted and sometimes even encouraged. Reproduced with permission of the copyright owner. Further reproduction prohibited without permission. Lesbian performances iv
Virtual teams: understanding the impact of fear

Distributed software development has become the norm for the software industry today. As a result many organizations are leveraging the expertise of their existing staff by establishing virtual teams. Here we outline the results from three independent case studies undertaken over a period of 8 years. The first study considered the operation of virtual teams whose members were situated in two locations in the same country. The second investigated why U.S. and Irish team members who worked very successfully while collocated, experienced serious problems when operating in virtual teams. The third focused on virtual testing teams with members based in Ireland and Malaysia. The Irish staffs had extensive experience of having projects offshored to them and were now responsible for offshoring part of their work. The results from each case study highlighted the importance and impact fear played and the consequences this had for the success of the respective strategies. Copyright © 2008 John Wiley & Sons, Ltd.
The role of invitations to parents in the completion of a child’s home reading challenge

Abstract The role parents can play in supporting early reading attainment is well documented. There is still, however, a need to understand what motivates parents to become involved in reading at home with their child. Past research, based upon correlational studies, has mixed findings regarding the influence of the teacher and the child on parents’ motivation at home. Through two quasi-experiments, the present study explored the influence of teacher invitations in Kindergarten classes, and child invitations in Grade 2 classes on completion rates of a home reading challenge. The completion of the home reading among families was investigated across two metropolitan schools in Sydney, Australia. Both of the interventions resulted in significantly higher completion rates compared to control groups (teacher invitations: d = .68; child invitations: d = .73). This paper adds to existing research by providing a clearer picture of the cause-and-effect relationship between schools’ use of invitations to facilitate children’s home reading.
The Relationship between Students’Perception of the Scientific Modelsand Their Alternative Conceptionsof the Lunar Phases

The aim of this study was to reveal whether there were differences in the understanding of scientific models according to their conceptions of lunar phases. The participants were 252 10th grader in South Korea. They were asked to respond SUMS (Students Understanding of Models in Science) instrument and to draw and explain why the different lunar phases occur. Students’ conceptions of lunar phases were analyzed qualitatively based on established criterions and the differences in the perception of scientific models, a one-way ANOVA was conducted. Results indicated that Korean students’ conceptions of the lunar phases were classified into five types: scientific, alternative, incomplete, eclipse explanation, and naive conception. The participants appeared to have different epistemological perceptions concerning each of the five subfactors in the scientific models. The students with a scientific conception of lunar phases tended to understand that multiple representations could be used to express the different dimensions of an object. It was found that Korean students have a good understanding of the role of models as explanatory tools(ET) and the changing nature of scientific models(CNM). There was statistically significant differences were shown in ET, USM(uses of scientific models) and CNM factors depending on the types of conceptions of the lunar phases.
Preweaning handling and shock : their relationship to subsequent adult emotionality and discrimination learning

Three groups of nine male hooded rats each were either daily shocked, daily handled, or l e f t undisturbed from three to 22 days of age. When 67 days old, a l l S_s were administered a series of emotionality tests followed by five days of training i n a brightness discrimination task which required a minimum of locomotion. This was followed by a drinking suppression test based on a conditioned fear measuring procedure designed by Leaf and Muller (1965). The shocked rats showed less emotionality and superior learning than the handled and nonhandled rats. The drinking suppression test failed to distinguish between the groups although there was a significant conditioning effect. A correlation of a l l the dependent measures indicated that differences in locomotor activity might have been reflected in the learning scores. It was concluded that infantile handling and shock affected adult emotionality and learning differently, and that neither manipulation produced unitary effects on the emotionality meaaures.
Human Service Organizations.

1. The Ubiquity of Human Service Organizations 2. Theoretical Approaches to Human Service Organizations 3. Organization-Environment Relations 4. Organizational Goals 5. Organizational 6. Technology 7. Structure, Power, and Control 8. Client-Organization Relations 9. Assessment of Organizational Performance 10. Changing Human Service Organizations References.
Off-Topic Spoken Response Detection Using Siamese Convolutional Neural Networks

In this study, we developed an off-topic response detection sys-tem to be used in the context of the automated scoring of non-native English speakers’ spontaneous speech. Based on transcriptions generated from an ASR system trained on non-native speakers’ speech and various semantic similarity features, the system classiﬁed each test response as an on-topic or off-topic response. The recent success of deep neural networks (DNN) in text similarity detection led us to explore DNN-based document similarity features. Speciﬁcally, we used a siamese adaptation of the convolutional network, due to its efﬁciency in learning similarity patterns simultaneously from both responses and questions used to elicit responses. In addition, a baseline sys-tem was developed using a standard vector space model (VSM) trained on sample responses for each question. The accuracy of the siamese CNN-based system was 0.97 and there was a 50% relative error reduction compared to the standard VSM-based system. Furthermore, the accuracy of the siamese CNN-based system was consistent across different questions.
The period gene in two species of tephritid fruit fly differentiated by mating behaviour

The period gene is important for the generation and maintenance of biological rhythms. It served as an ideal candidate for the investigation of the mating time isolation between two sibling Queensland fruit fly species, Bactrocera tryoni and Bactrocera neohumeralis. We have isolated the homologues of the period gene in the two species, and show that their putative amino acid sequences are identical. No length polymorphism was detected in the Thr‐Gly repeat region. per mRNA expression, assayed in light–dark diurnal conditions, displayed circadian oscillation in both the head and abdomen of B. tryoni and B. neohumeralis, with the same cycling phase. An alternatively spliced intron was identified in the 3′ untranslated region. The effect of temperature on the splicing and mRNA expression was examined.
Caspases 3 and 7: Key Mediators of Mitochondrial Events of Apoptosis

The current model of apoptosis holds that upstream signals lead to activation of downstream effector caspases. We generated mice deficient in the two effectors, caspase 3 and caspase 7, which died immediately after birth with defects in cardiac development. Fibroblasts lacking both enzymes were highly resistant to both mitochondrial and death receptor–mediated apoptosis, displayed preservation of mitochondrial membrane potential, and had defective nuclear translocation of apoptosis-inducing factor (AIF). Furthermore, the early apoptotic events of Bax translocation and cytochrome c release were also delayed. We conclude that caspases 3 and 7 are critical mediators of mitochondrial events of apoptosis.
Predictive factors for BRCA1/BRCA2 mutations in women with ductal carcinoma in situ

It is unclear whether women with ductal carcinoma in situ (DCIS), like their counterparts with invasive breast cancer, warrant genetic risk assessment and testing on the basis of high‐risk variables. The authors of this report identified predictive factors for mutations in the breast cancer‐susceptibility genes BRCA1 and BRCA2 in women who were diagnosed with DCIS.
Helminth community structure of 13 species of anurans from Atlantic rainforest remnants, Brazil

Abstract This study aimed to evaluate the community composition and structure of the helminths found in 13 anuran species, and to evaluate whether this parasite community is determined by anuran characteristics. We found that the helminth fauna of the amphibians from five anuran families consisted of 13 taxa and that Cosmocercidae gen. sp. was the most prevalent taxon, followed by Oswaldocruzia subauricularis. Host body size was a determining factor of the composition and structure of the parasitic fauna. Helminth abundance and richness were positively correlated with host body size. The host Leptodactylus latrans had the highest helminth richness (n = 8). The frog Hypsiboas faber had the greatest helminth diversity (H′ = 0.711). The mean helminth species richness and diversity differed significantly between host species (P < 0.05). Taken together, our data indicate that, in sympatric species of amphibians, the morphological and behavioural characteristics of the hosts are important for structuring the helminth parasite communities.
VERTEBRAL BODY REPLACEMENT SYSTEMS WITH EXPANDABLE CAGES IN THE TREATMENT OF VARIOUS SPINAL PATHOLOGIES: A PROSPECTIVELY FOLLOWED CASE SERIES OF 60 PATIENTS

OBJECTIVEVertebral body reconstruction after corpectomy has become a common surgical procedure. The authors describe a prospectively followed case series of patients treated with expandable cages for various indications. METHODSSixty patients underwent single or multilevel corpectomy for degenerative stenosis (13 patients), herniated disc (7 patients), deformity (14 patients), traumatic fracture (3 patients), infection (1 patient), or tumor (22 patients). Six different expandable vertebral body systems were used in the cervical spine (41 patients), thoracic spine (15 patients), and lumbar spine (4 patients). All patients were evaluated clinically and radiographically. RESULTSThirty-nine patients underwent single-level corpectomy, 18 patients underwent two-level corpectomy, and 3 patients underwent three-level corpectomy. Anterior reconstruction alone was performed in 30 patients; circumferential reconstruction was performed in 30 patients, 9 of whom underwent reconstruction through a posterior approach only. At the time of the final follow-up examination (mean, 9 mo), the Nurick grade improved significantly. Ninety-five percent of the patients maintained or improved their Frankel score and 67% had good clinical results. The regional angulation was corrected significantly (4.0 ± 9.0 degrees, P = 0.002), and the segment height increased significantly (3.5 ± 8.0 mm, P = 0.002). Bony fusion was achieved in 93% of the cases. Subsidence was documented in nearly half of the patients (1.4 ± 2.0 mm) and was reduced after circumferential fusion (0.9 ± 1.9 mm, P = 0.08). Eighteen patients (30%) had complications and 12 patients (20%) underwent revision surgery. CONCLUSIONExpandable vertebral body replacement systems can provide solid anterior column constructs with restoration of height and sagittal alignment. Favorable clinical outcome was shown in most patients, although the complication and reoperation rates are rather high.
Socio-Demographic, Clinical and Behavioral Characteristics Associated with a History of Suicide Attempts among Psychiatric Outpatients: A Case Control Study in a Northern Mexican City

Background: Little is known about the epidemiology of suicide attempts among psychiatric outpatients in Mexico. This study was aimed to determine the socio-demographic, clinical and behavioral characteristics associated with suicide attempts in psychiatric outpatients in two public hospitals in Durango, Mexico. Methods: Two hundred seventy six psychiatric outpatients (154 suicide attempters and 122 patients without suicide attempt history) attended the two public hospitals in Durango City, Mexico were included in this study. Socio-demographic, clinical and behavioral characteristics were obtained retrospectively from all outpatients and compared in relation to the presence or absence of suicide attempt history. Results: Increased prevalence of suicide attempts was associated with mental and behavioral disorders due to psychoactive substance use (F10-19) (P=0.01), schizophrenia, schizotypal and delusional disorders (F20-29) (P=0.02), mood (affective) disorders (F30-39) (P<0.001), and disorders of adult personality and behavior (F60-69) (P<0.001). Multivariate analysis showed that suicide attempts were associated with young age (OR=1.21, 95% CI: 1.06-1.39; P=0.003), female gender (OR=2.98, 95% CI: 1.55-5.73; P=0.001), urban residence (OR=2.31, 95% CI: 1.17-4.57; P=0.01), memory impairment (OR=1.91, 95% CI: 1.07-3.40; P=0.02), alcohol consumption (OR=2.39, 95% CI: 1.21-4.70; P=0.01), and sexual promiscuity (OR=3.90, 95% CI: 1.74-8.77; P<0.001). Conclusions: We report the association of suicide attempts with socio-demographic, clinical and behavioral characteristics in psychiatric outpatients in Mexico. Results may be useful for an optimal planning of preventive measures against suicide attempts in psychiatric outpatients.
Twin Clouds: An Architecture for Secure Cloud Computing

Cloud computing promises a more cost effective enabling technology to outsource storage and computations. Existing approaches for secure outsourcing of data and arbitrary computations are either based on a single tamper-proof hardware, or based on recently proposed fully homomorphic encryption. The hardware based solutions are not scaleable, and fully homomorphic encryption is currently only of theoretical interest and very inefficient. In this paper we propose an architecture for secure outsourcing of data and arbitrary computations to an untrusted commodity cloud. In our approach, the user communicates with a trusted cloud (either a private cloud or built from multiple secure hardware modules) which encrypts and verifies the data stored and operations performed in the untrusted commodity cloud. We split the computations such that the trusted cloud is mostly used for security-critical operations in the less time-critical setup phase, whereas queries to the outsourced data are processed in parallel by the fast commodity cloud on encrypted data.
Recent measurements of single electron transport in surface acoustic wave devices at the NPL

The quantized acoustoelectric current (QAC) induced by a surface acoustic wave in a one-dimensional channel, offers the possibility of a quantum current standard. We report on the accuracy and flatness of the QAC for several plateaux and demonstrate an empirical relationship between the current error and plateaux slopes. The temperature dependence of the QAC is also discussed.
Address for Correspondence Association of the Gstp1 and Nqo1 Polymorphisms and Head and Neck Squamous Cell Carcinoma Risk

The GSTP1 and NQO1 have been reported to be associated with an increased risk for smoking related head and neck squamous cell carcinoma (HNSCC). The purpose of this study was to determine the effect of these metabolic gene polymorphisms on the risk of HNSCC. The study population included 294 histologically confirmed HNSCC cases and 333 controls without cancer. Genotyping analysis of the GSTP1 Ile105Val and NQO1 Trp139Arg genes was performed by polymerase chain reaction based techniques on DNA prepared from peripheral blood. The Mantel-Haen-szel 2 test was used for statistical analysis. The allele frequencies of the GSTP1 and NQO1 polymorphisms were not statistically significant between cases and controls. In analyzing the association between smoking amounts and genetic polymor-phisms, GSTP1 and NQO1 polymorphisms were associated with cigarette smoking amounts in cases. G allele containing genotypes in GSTP1 and T allele containing genotypes in NQO1 were associated with a tobacco dose-dependent increase in risk of HNSCC and these genotype distributions were statistically significant (p< 0.05). We found that the GSTP1 105Val allele and NQO1 139Arg allele were associated with tobacco dose-dependent increase in risk of HNSCC. GSTP1 and NQO1 genotype polymorphisms may play an important role in the development of smoking related HNSCC.
"A Tub to the Whale": The Founding Fathers and Adoption of the Federal Bill of Rights

Seamen have a custom, when they meet a whale, to fling him out an empty tub by way o f amusement, to divert him from laying violent hands upon the ship. Jonathan Swift, Tale of a Tub (1704) Like a barrel thrown to the whale, the people were to be amused with fancied amendments, until the harpoon of power, should secure its prey and render resistance ineffectual. [Samuel Bryan], ' 'Centinel NO. 19, ' ' (Philadelphia) Independent Gazetteer, October 7, 1788
Factors Associated With Pre-hospital Delay in Patients With Acute Myocardial Infarction

Background Treatment of patients with acute myocardial infarction (AMI) is time related, so delay in treatment could affect prognosis. Recognizing pre-hospital or in-hospital delays in initiating treatment and reducing these factors is very efficacious in treatment of these patients. Objectives The aim of this study is evaluate the causes of pre-hospital delay just as other studies on effect of different variables such as socioeconomic and personal factors on pre-hospital delay in with patients with AMI. Materials and Methods A cross sectional study was carried out on 227 patients with acute myocardial infarction and demographic data, educational level, marital status, type of transfer to hospital and delay in arrival to hospital were recorded. Results 35.7% patients arrived during one hour of symptom onset, and 7.9% arrived after 24 hours. Patients having high level education (P = 0.0492) and with a family history of coronary artery disease (P = 0.01) had significantly less delay in arriving to hospital. Age, marital status, gender, and route of transfer to hospital were not related with pre-hospital delay (P > 0.05). Patients thought most common cause of delay in arrival was unawareness of coronary artery disease (38.8%) and self-medication (34.3%). Conclusions Increasing awareness of patients about cardiovascular symptoms and their risk factors could be helpful in patient's decision in seeking medical help. So general education via media and primary and middle schools could be helpful.