Miracle-dz/UniFAR-FTUs huggingface dataset:
Genes and neurons: molecular insights to fear and anxiety

Experimental animal models provide an important tool for the identification of inheritable components of fear and anxiety. ‘Pavlovian’ fear conditioning has been tremendously successful to characterize the neuronal circuitry and cellular mechanisms of the formation, consolidation and extinction of fear memories. Here we summarize recent progress that has led to the identification of gene products contributing to such experience‐dependent changes in fear and anxiety and may guide the search for genetic factors involved in the development and treatment of human anxiety disorders.
Real-time MPC - Stability through robust MPC design

Recent results have suggested that online Model Predictive Control (MPC) can be computed quickly enough to control fast sampled systems. High-speed applications impose a hard real-time constraint on the solution of the MPC problem, which generally prevents the computation of the optimal controller. In current approaches guarantees on feasibility and stability are sacrificed in order to achieve a real-time setting. In this paper we develop a real-time MPC scheme based on robust MPC design that recovers these guarantees while allowing for extremely fast computation. We show that a simple warm-start optimization procedure providing an enhanced feasible solution guarantees feasibility and stability for arbitrary time constraints. The proposed method can be practically implemented and efficiently solved for dynamic systems of significant problem size. Implementation details for a real-time robust MPC method are provided that achieves computation times equal to those reported for methods without guarantees. A 12-dimensional problem with 3 control inputs and a prediction horizon of 10 time steps is solved in 2msec with a performance deterioration less than 1% and thereby allows for sampling rates of 500Hz.
Comparative study of community versus hospital-acquired Staphylococcus aureus bacteraemia.

OBJECTIVES We prospectively investigated 274 consecutive Staphylococcus aureus septicaemias in adult patients between January 1983 and December 1989 to evaluate outcome in hospital acquired and community acquired episodes. METHODS Epidemiologic, clinical, laboratory and therapeutic parameters were analyzed with univariate and multivariate statistical tests. RESULTS AND CONCLUSIONS Ninety episodes of Staphylococcus aureus bacteraemia were acquired in the community and 184 in hospital. Diabetes mellitus and renal failure were accompanied by a clear increase in bacteraemia related death in the community-acquired category. Correct antibiotic therapy showed a better response in the community-acquired group. Bacteraemia related death was 22.6% for episodes acquired in the hospital and 18.8% for those originating in the community.
HIV controls the selective packaging of genomic, spliced viral and cellular RNAs into virions through different mechanisms

In addition to genomic RNA, HIV-1 particles package cellular and spliced viral RNAs. In order to determine the encapsidation mechanisms of these RNAs, we determined the packaging efficiencies and specificities of genomic RNA, singly and fully spliced HIV mRNAs and different host RNAs species: 7SL RNA, U6 snRNA and GAPDH mRNA using RT-QPCR. Except GAPDH mRNA, all RNAs are selectively encapsidated. Singly spliced RNAs, harboring the Rev-responsible element, and fully spliced viral RNAs, which do not contain this motif, are enriched in virions to similar levels, even though they are exported from the nucleus by different routes. Deletions of key motifs (SL1 and/or SL3) of the packaging signal of genomic RNA indicate that HIV and host RNAs are encapsidated through independent mechanisms, while genomic and spliced viral RNA compete for the same trans-acting factor due to the presence of the 5′ common exon containing the TAR, poly(A) and U5-PBS hairpins. Surprisingly, the RNA dimerization initiation site (DIS/SL1) appears to be the main packaging determinant of genomic RNA, but is not involved in packaging of spliced viral RNAs, suggesting a functional interaction with intronic sequences. Active and selective packaging of host and spliced viral RNAs provide new potential functions to these RNAs in the early stages of the virus life cycle.
Population genetic diversity influences colonization success

Much thought has been given to the individual‐level traits that may make a species a successful colonizer. However, these traits have proven to be weak predictors of colonization success. Here, we test whether population‐level characteristics, specifically genetic diversity and population density, can influence colonization ability on a short‐term ecological timescale, independent of longer‐term effects on adaptive potential. Within experimentally manipulated populations of the weedy herb Arabidopsis thaliana, we found that increased genetic diversity increased colonization success measured as population‐level seedling emergence rates, biomass production, flowering duration, and reproduction. Additive and non‐additive effects contributed to these responses, suggesting that both individual genotypes (sampling effect) and positive interactions among genotypes (complementarity) contributed to increased colonization success. In contrast, manipulation of plant density had no effect on colonization success. The heightened ability of relatively genetically rich populations to colonize novel habitats, if a general phenomenon, may have important implications for predicting and controlling biological invasions.
Importance of Extracellular Polymeric Substances from Thiobacillus ferrooxidans for Bioleaching

ABSTRACT Leaching bacteria such as Thiobacillus ferrooxidansattach to pyrite or sulfur by means of extracellular polymeric substances (EPS) (lipopolysaccharides). The primary attachment to pyrite at pH 2 is mediated by exopolymer-complexed iron(III) ions in an electrochemical interaction with the negatively charged pyrite surface. EPS from sulfur cells possess increased hydrophobic properties and do not attach to pyrite, indicating adaptability to the substrate or substratum.
Comparison of Pure Palm Olein Oil, Hydrogenated Oil-Containing Palm, and Canola on Serum Lipids and Lipid Oxidation Rate in Rats Fed with these Oils.

BACKGROUND Due to increased consumption of canola oil and hydrogenated oil containing palm and palm olein, and their possible effects on serum lipoproteins, the present study was conducted to determine the effects of these oils on lipids and lipid oxidation level. METHODS In this experimental study, 88 Wistar rats were randomly assigned to four groups. Control group (A) was on a normal diet. Groups B, C, and D, in addition to normal diet, were fed with hydrogenated oil-contained palm oil, pure palm olein oil, and canola oil, respectively for 4 weeks. Serum Biochemical factors [total cholesterol (TC), triglyceride (TG), LDL, HDL, LDL/HDL ratio, oxLDL, paraoxanase-1 (PON1), and malondialdehyde (MDA)] were measured. RESULTS The lowest mean serum TC was seen in the control group and the highest in the group B. There were differences in TC, TG, HDL, MDA, and PON1 between the control group and other groups (P<0.001). The lowest and highest LDL/HDL ratios were observed in the group C and the control group, respectively. Significant differences were seen in OxLDL and PON1 between the control group and other three groups (P<0.05), while there were no significant differences in oxLDL and PON1 among the other three groups (P>0.05). MDA was higher in groups C and D. CONCLUSION Canola oil, hydrogenated oil-containing palm and palm olein may increase atherosclerosis risk through decreasing PON1 activity and elevating oxLDL. Palm olein oils in rats' diets cause a considerable decrease in LDL and help to increase HDL.
Connections of the tectum of the rattlesnake crotalus viridis: An HRP study

We have studied the connections of the tectum of the rattlesnake by tectal application of horseradish peroxidase. The tectum receives bilateral input from nucleus lentiformis mesencephali, posterolateral tegmental nuclei, anterior tegmental nuclei and periventricular nuclei; ipsilateral input from nucleus geniculatus pretectalis, and lateral geniculate nucleus pars dorsalis; and contralateral input from dorso‐lateral posterior tegmental nucleus and the previously undescribed nucleus reticularis caloris (RC). RC is located on the ventro‐lateral surface of the medulla and consists of large cells 25–45 μm in diameter. Efferent projections from the tectum can be traced to the ipsilateral nucleus lentiformis mesencephali, the ipsilateral lateral geniculate region, anterior tegmental region and a wide bilateral area of the neuropil of the ventral tegmentum and ventral medulla. We have not found any direct tectal projections from the sensory trigeminal nuclei including the nucleus of the lateral descending trigeminal tract (LTTD). We suggest that in the rattlesnake, RC is the intermediate link connecting LTTD to the tectum.
Comparison of two different S-1 plus cisplatin dosing schedules as first-line chemotherapy for metastatic and/or recurrent gastric cancer: a multicenter, randomized phase III trial (SOS).

BACKGROUND Five-weekly S-1 plus cisplatin (SP5) is one of the standard first-line regimens for advanced gastric cancer (GC), proven in a Japanese phase III study. To enhance the dose intensity of cisplatin, 3-weekly S-1 plus cisplatin (SP3) was developed. PATIENTS AND METHODS This multicenter, randomized, open-label, phase III study evaluated whether SP3 (S-1 80 mg/m(2)/day on days 1-14 and cisplatin 60 mg/m(2) on day 1) was noninferior/superior to SP5 (S-1 80-120 mg/day on days 1-21 and cisplatin 60 mg/m(2) on day 1 or 8) in terms of progression-free survival (PFS). Chemotherapy-naive patients with metastatic, recurrent gastric or gastroesophageal junction adenocarcinoma were randomized 1 : 1 to receive either SP3 or SP5. The trial is registered at ClinicalTrials.gov (NCT00915382). RESULTS Between February 2009 and January 2012, 625 patients were randomized at 42 sites in Korea and Japan. With a median follow-up duration of 32.4 months (range, 13.3-48.6 months) in surviving patients, SP3 was not only noninferior but also superior to SP5 in terms of PFS [median 5.5 versus 4.9 months; hazard ratio (HR) = 0.82; 95% confidence interval (CI) 0.68-0.99; P = 0.0418 for superiority). There was no difference in overall survival (OS) between the groups (median 14.1 versus 13.9 months; HR = 0.99; 95% CI 0.81-1.21; P = 0.9068). In patients with measurable disease, the response rates were 60% in the SP3 arm and 50% in the SP5 arm (P = 0.065). Both regimens were generally well tolerated, but grade 3 or higher anemia (19% versus 9%) and neutropenia (39% versus 9%) were more frequent in SP3. CONCLUSIONS SP3 is superior to SP5 in terms of PFS. However, since the improvement in PFS was only slight and there was no difference in OS, both SP3 and SP5 can be recommended as first-line treatments for patients with advanced GC.
Bcl-2 expression in breast cancer: a comparative study at the mRNA and protein level.

BACKGROUND Bcl-2 is one of the most important antiapoptotic genes. Although it facilitates the survival of tumor cells, its expression has been consistently associated with a better prognosis for breast cancer. Virtually all studies on Bcl-2 conducted in breast cancer have been carried out by means of immunohistochemistry. The aim of this study was to examine for the first time the expression of Bcl-2 in a series of human breast cancer, both at the mRNA and protein level. MATERIALS AND METHODS One hundred samples from previously untreated human breast cancers were used; Bcl-2 expression was determined both by means of immunohistochemistry using the bcl-2/100/D5 monoclonal antibody and differential RT-PCR. Additionally, the expression of hormone receptors (ER and PR), c-erb-B2, p53 and the proliferation-associated Ki-67 antigen were also studied by means of immunohistochemistry as part of the standard pathological workup. RESULTS Any degree of immunohistochemical staining correlated significantly and inversely with c-erb-B2 expression (p = 0.0008), nuclear grade 3 (p = 0.0015), a Ki-67 labeling index > 10% (p = 0.02) and tumor size (p = 0.048), and in a direct fashion with estrogen (p = 0.0003) and progesterone receptor expression (p = 0.0002). mRNA expression of the Bcl-2 gene showed a significant inverse correlation with c-erb-B2 (p = 0.016) and p53 (p = 0.014) expression, as well as with a nuclear grade 3 (p = 0.006), and a direct correlation with estrogen (p = 0.0004) and progesterone (p = 0.001) receptor expression, as well as with nodal invasion (p = 0.04). CONCLUSION The study of Bcl-2 expression in breast cancer by means of either immunohistochemistry or RT-PCR yields very similar results. In spite of its role opposing tumor cell death, Bcl-2 is associated with biological features of the tumors which define a better intrinsic prognosis, such as hormone receptor expression, low proliferation and absence of c-erb-B2 and mutant p53 expression. This may in great part explain why Bcl-2 expression has been invariably found to correlate with a better prognosis of breast cancer.
Exploiting FPGA block memories for protected cryptographic implementations

Modern Field Programmable Gate Arrays (FPGAs) are power packed with features to facilitate designers. Availability of features like huge block memory (BRAM), Digital Signal Processing (DSP) cores, embedded CPU makes the design strategy of FPGAs quite different from ASICs. FPGA are also widely used in security-critical application where protection against known attacks is of prime importance. We focus ourselves on physical attacks which target physical implementations. To design countermeasures against such attacks, the strategy for FPGA designers should also be different from that in ASIC. The available features should be exploited to design compact and strong countermeasures. In this paper, we propose methods to exploit the BRAMs in FPGAs for designing compact countermeasures. BRAM can be used to optimize intrinsic countermeasures like masking and dual-rail logic, which otherwise have significant overhead (at least 2X). The optimizations are applied on a real AES-128 co-processor and tested for area overhead and resistance on Xilinx Virtex-5 chips. The presented masking countermeasure has an overhead of only 16% when applied on AES. Moreover Dual-rail Precharge Logic (DPL) countermeasure has been optimized to pack the whole sequential part in the BRAM, hence enhancing the security. Proper robustness evaluations are conducted to analyze the optimization for area and security.
Lifetime and conductance of acetylcholine‐activated channels in normal and denervated toad sartorius muscle.

1. The average lifetime and conductance of acetylcholine‐activated channels were measured in normal and denervated, voltage‐clamped toad sartorius muscle fibres at 10 degrees C. 2. The null potential was ‐4 +/‐ 1 mV for subsynaptic channels in normal fibres and ‐6 +/‐ 3 mV for extrasynaptic channels in denervated fibres. 3. There was a linear relationship between variance of conductance fluctuations and mean conductance for acetylcholine‐induced currents up to 50 nA, in denervated fibres clamped at ‐50 mV. The ratio gave a channel conductance of 14 pS. 4. At the same membrane potential, the average lifetime of extrasynaptic channels in denervated fibres was approximately double, whereas channel conductance was approximately half, that of subsynaptic channels in normal fibres: there was little difference in net charge transfer through the two types of channel under similar conditions. 5. Single channel conductance increased, whereas average channel lifetime decreased, as the membrane potential became more positive (depolarized). The effect of potential on channel lifetime and conductance was more pronounced in denervated than in normal fibres.
Wireless Information and Power Transfer in Cooperative Networks With Spatially Random Relays

In this paper, the application of wireless information and power transfer to cooperative networks is investigated, where the relays in the network are randomly located and based on the decode-forward strategy. For the scenario with one source-destination pair, three different strategies for using the available relays are studied, and their impact on the outage probability and diversity gain is characterized by applying stochastic geometry. By using the assumptions that the path loss exponent is two and that the relay-destination distances are much larger than the source-relay distances, closed form analytical results can be developed to demonstrate that the use of energy harvesting relays can achieve the same diversity gain as the case with conventional self-powered relays. For the scenario with multiple sources, the relays can be viewed as a type of scarce resource, where the sources compete with each other to get help from the relays. Such a competition is modeled as a coalition formation game, and two distributed game theoretic algorithms are developed based on different payoff functions. Simulation results are provided to confirm the accuracy of the developed analytical results and facilitate a better performance comparison.
Exhaled nitric oxide in 4-year-old children: relationship with asthma and atopy

Airway inflammation is an early feature of asthma. Early detection and anti-inflammatory treatment may have important therapeutic impact. Exhaled nitric oxide is a noninvasive marker of airway inflammation. The current study investigated the association between exhaled nitric oxide and asthma, wheezing phenotypes, atopy and blood eosinophilia in a large group of 4-yr-old children from the general population. All children participated in the Prevention and Incidence of Asthma and Mite Allergy study, a birth cohort study of high-risk (atopic mother) and low-risk children in the Netherlands. Nitric oxide levels were successfully determined in 429 children. Although there was overlap in the distribution of values of children with and without asthma or atopy, mean values were higher in children with atopy or doctor's diagnosed asthma (geometric mean (ppb) 9.4 and 10.0, respectively) as compared to those without (7.7 and 7.9). Values were highest in atopic symptomatic children. Values were not associated with wheezing phenotype or blood eosinophilia. This study is one of the few large-scale epidemiological studies among 4-yr-old children from the general population showing that children with symptoms of asthma and atopy have higher levels of exhaled nitric oxide than those without.
Coplanar circulator made from composite magnetic material

This paper deals with the operation of a Y-junction coplanar circulator. It operates at high frequencies (>40 GHz). Barium hexaferrite particles within a host matrix form the integrated magnetic material in this device. The structure of this 3-port microwave device and its different characteristics are presented. A three dimensional finite element method was used to calculate the S-parameters and to evaluate numerically the performance of the circulator. These parameters were measured using a vector network analyzer after the fabrication process showing the performance of the device.
Do Multinational Enterprises Contribute to Convergence or Divergence? A Disaggregated Analysis of US FDI

It is widely held that foreign direct investment (FDI) has a positive effect on economic growth. To test this hypothesis, we perform convergence regressions derived from a theoretical model on the impact of FDI on endogenous technological change in small economies. The model includes FDI externalities that enhance growth, but also shows that FDI can crowd out host country income and reduce local innovation. The empirical analysis employs disaggregated US data for various FDI-related activities-in addition to the conventionally used aggregate FDI stocks and flows. We estimate the net FDI impact on the convergence rate of per-capita income to US levels, controlling for human development, financial development, and trade. We find that FDI accelerates convergence for high-income countries only, otherwise slowing it down. Copyright © 2009 The Authors. Journal compilation © 2009 Blackwell Publishing Ltd.
Simvastatin Normalizes Autonomic Neural Control in Experimental Heart Failure

Background—HMG-CoA reductase inhibitors (statins) have been shown to beneficially affect outcomes in chronic heart failure (CHF). We hypothesized that statins exert effects on autonomic function, as assessed by plasma norepinephrine levels, direct recordings of renal sympathetic nerve activity (RSNA), and baroreflex function. Methods and Results—Normolipidemic CHF rabbits were treated with simvastatin or vehicle. CHF was induced by continuous ventricular pacing at 320 to 340 bpm for 3 weeks. Two to 3 days after instrumentation of the rabbits with renal nerve electrodes and arterial and venous catheters, blood samples and RSNA recordings were obtained in the conscious state. Baroreflex function was assessed after administration of sodium nitroprusside and phenylephrine. Mean baseline RSNA (±SEM) in normal rabbits was 19.3±3.8%; in CHF rabbits, 39.4±2.9% (P <0.05); in CHF rabbits on low-dose (0.3 mg · kg−1 · d−1) simvastatin, 39.8±8.3% (P <0.05); and in CHF rabbits on high-dose simvastatin (3 mg · kg−1 · d−1), 21.1±4.5% (P =NS). Similar data were observed for plasma norepinephrine. In CHF rabbits treated with 3 mg · kg−1 · d−1 simvastatin, baroreflex regulation of heart rate to transient hypotension with sodium nitroprusside was normalized by 66% compared with CHF controls. Conclusions—These are the first data showing that non–lipid-lowering statin effects include a normalization of sympathetic outflow and reflex regulation in CHF. The precise neural and cellular pathways involved in these responses need further clarification. This finding may have important implications for the treatment of CHF and progression of the disease process.
Nonsurgical Treatment of Appendiceal Abscess or Phlegmon: A Systematic Review and Meta-analysis

Objective:A systematic review of the nonsurgical treatment of patients with appendiceal abscess or phlegmon, with emphasis on the success rate, need for drainage of abscesses, risk of undetected serious disease, and need for interval appendectomy to prevent recurrence. Summary Background Data:Patients with appendiceal abscess or phlegmon are traditionally managed by nonsurgical treatment and interval appendectomy. This practice is controversial with proponents of immediate surgery and others questioning the need for interval appendectomy. Methods:A Medline search identified 61 studies published between January 1964 and December 2005 reporting on the results of nonsurgical treatment of appendiceal abscess or phlegmon. The results were pooled taking the potential clustering on the study-level into account. A meta-analysis of the morbidity after immediate surgery compared with that after nonsurgical treatment was performed. Results:Appendiceal abscess or phlegmon is found in 3.8% (95% confidence interval (CI), 2.6–4.9) of patients with appendicitis. Nonsurgical treatment fails in 7.2% (CI: 4.0–10.5). The need for drainage of an abscess is 19.7% (CI: 11.0–28.3). Immediate surgery is associated with a higher morbidity compared with nonsurgical treatment (odds ratio, 3.3; CI: 1.9–5.6; P < 0.001). After successful nonsurgical treatment, a malignant disease is detected in 1.2% (CI: 0.6–1.7) and an important benign disease in 0.7% (CI: 0.2–11.9) during follow-up. The risk of recurrence is 7.4% (CI: 3.7–11.1). Conclusions:The results of this review of mainly retrospective studies support the practice of nonsurgical treatment without interval appendectomy in patients with appendiceal abscess or phlegmon.