Miracle-dz/UniFAR-FTUs huggingface dataset:
Dementia and Its Implications for Public Health

Introduction With the aging of the U.S. population, a better understanding of the presentation and impact of dementia is essential to the future of public health. Dementia refers not to a single disorder but to a number of syndromes characterized by diverse behavioral, cognitive, and emotional impairments. Because dementia is costly in terms of both personal suffering and economic loss, an understanding of its prevalence, risk factors, and potential interventions is emerging as an increasingly important facet of public health and health care delivery. Recent advances in the understanding of its presentation, course, and relevant interventions have taken place. Methods We identified articles for review primarily by conducting a Medline search using the subject headings dementia, mild cognitive impairment, Alzheimer's disease, vascular dementia, frontotemporal dementia, and Lewy body dementia. Other relevant studies were elicited through a Medline search using the subject headings mental disorders and stigma. Results Dementia represents a diverse category of syndromes characterized by deficits in memory, cognitive function, and behavior. Symptoms associated with dementia appear to be distributed along a continuum, with even subsyndromal presentations affecting the health of older adults and meriting intervention. To promote cognitive functioning and independence among older adults, public health interventions need to facilitate both early detection and treatment of dementia. The availability of adult day care and respite services is important in maintaining the health and quality of life of individuals caring for older adults with dementia. Recent advances in the treatment of dementia may slow the course of cognitive decline, thereby enhancing the quality of life of older individuals as well as decreasing costs associated with institutional care. Conclusion Despite the growing availability of pharmacologic and psychosocial interventions that are potentially helpful to people with dementia and their caregivers, the majority of older adults with dementia do not receive appropriate treatment. With the aging of the U.S. population, efforts to foster recognition of dementia and its treatments and to destigmatize them are emerging as an increasingly important facet of public health intervention.
Corner Detection and Classification Using Anisotropic Directional Derivative Representations

This paper proposes a corner detector and classifier using anisotropic directional derivative (ANDD) representations. The ANDD representation at a pixel is a function of the oriented angle and characterizes the local directional grayscale variation around the pixel. The proposed corner detector fuses the ideas of the contour- and intensity-based detection. It consists of three cascaded blocks. First, the edge map of an image is obtained by the Canny detector and from which contours are extracted and patched. Next, the ANDD representation at each pixel on contours is calculated and normalized by its maximal magnitude. The area surrounded by the normalized ANDD representation forms a new corner measure. Finally, the nonmaximum suppression and thresholding are operated on each contour to find corners in terms of the corner measure. Moreover, a corner classifier based on the peak number of the ANDD representation is given. Experiments are made to evaluate the proposed detector and classifier. The proposed detector is competitive with the two recent state-of-the-art corner detectors, the He & Yung detector and CPDA detector, in detection capability and attains higher repeatability under affine transforms. The proposed classifier can discriminate effectively simple corners, Y-type corners, and higher order corners.
InP-InGaAs single HBT technology for photoreceiver OEIC's at 40 Gb/s and beyond

We describe an advanced InP-InGaAs-based technology for the monolithic integration of pin-photodiodes and SHBT-transistors. Both devices are processed using the same epitaxial grown layer structure. Employing this technology, we have designed and fabricated two photoreceivers achieving transimpedance gains of 170 /spl Omega//380 /spl Omega/ and optical/electrical bandwidths of 50 GHz/34 GHz. To the best of our knowledge, this is the highest bandwidth of any heterojunction bipolar transistor (HBT)-based photoreceiver optoelectronic integrated circuit (OEIC) published to date. We even predict a bandwidth of 60 GHz for the same circuit topology by a simple reduction of the photodiode diameter and an adjustment of the feedback resistor value.
Fish, Long-Chain n-3 PUFA and Incidence of Elevated Blood Pressure: A Meta-Analysis of Prospective Cohort Studies

Results from prospective cohort studies on fish or long-chain (LC) n-3 polyunsaturated fatty acid (PUFA) intake and elevated blood pressure (EBP) are inconsistent. We aimed to investigate the summary effects. Pertinent studies were identified from PubMed and EMBASE database through October 2015. Multivariate-adjusted risk ratios (RRs) for incidence of EBP in the highest verses the bottom category of baseline intake of fish or LC n-3 PUFA were pooled using a random-effects meta-analysis. Over the follow-up ranging from 3 to 20 years, 20,497 EBP events occurred among 56,204 adults from eight prospective cohort studies. The summary RR (SRR) was 0.96 (95% CI: 0.81, 1.14; I2 = 44.70%) for fish in four studies, and 0.73 (95% CI: 0.60, 0.89; I2 = 75.00%) for LC n-3 PUFA in six studies (three studies for biomarker vs. three studies for diet). Circulating LC n-3 PUFA as biomarker was inversely associated with incidence of EBP (SRR: 0.67; 95% CI: 0.55, 0.83), especially docosahexaenoic acid (SRR: 0.64; 95% CI: 0.45, 0.88), whereas no significant association was found for dietary intake (SRR: 0.80; 95% CI: 0.58, 1.10). The present finding suggests that increased intake of docosahexaenoic acid to improve its circulating levels may benefit primary prevention of EBP.
Neurotrophins and neuronal plasticity in the action of antidepressants and morphine

Neuronal plasticity is a well characterized phenomenon in the developing and adult brain. It refers to capasity of a single neuron to modify morphology, synaptic connections and activity. Neuronal connections and capacity for plastic events are compromised in several pathological disorders, such as major depression. In addition, neuronal atrophy has been reported in depressive patients. Neurotrophins are a group of secretory proteins functionally classified as neuronal survival factors. Neurotrophins, especially brain derived neurotrophic factor (BDNF), have also been associated with promoting neuronal plasticity in dysfunctional neuronal networks. Chronic antidepressant treatment increases plastic events including neurogenesis and arborization and branching of neurites in distinct brain areas, such as the hippocampus. One suggested mode of action is where the antidepressants elevate the synaptic levels of BDNF thus further activating several signaling cascades via trkB-receptor. In our studies we have tried to clarify the mechanisms of action for antidepressants and to resolve the role of BDNF in this process. We found that chronic antidepressant treatment increases amount of markers of neuronal plasticity in both hippocampus and in the medial prefrontal cortex, both of which are closely linked to the etiology of major depression. Secondary actions of antidepressants include rapid activation of the trkB receptor followed by a phosphorylation of transcription factor CREB. In addition, activation of CREB by phosphorylation appears responsible for the regulation of the expression of the BDNF gene. Using transgenic mice we found that BDNF-induced trkB-mediated signaling proved crucial for the behavioral effects of antidepressants in the forced swimming test and for the survival of newly-born neurons in the adult hippocampus. Antidepressants not only increased neurogenesis in the adult hippocampus but also elevated the turnover of hippocampal neurons. During these studies we also discovered that another trkB ligand, NT-4, is involved in morphine-mediated antinociception and tolerance. These results present a novel role for trkB-mediated signaling in plastic events present in the opioid system. This thesis evaluates neuronal plasticity and trkB as a target for future antidepressant treatments.
Growth factor and cytokine regulation of chondroitin sulfate proteoglycans by astrocytes

After injury to the adult central nervous system (CNS), numerous cytokines and growth factors are released that contribute to reactive gliosis and extracellular matrix production. In vitro examination of these cytokines revealed that the presence of transforming growth factor‐β1 (TGF‐β1) and epidermal growth factor (EGF) greatly increased the production of several chondroitin sulfate proteoglycans (CSPG) by astrocytes. Treatment of astrocytes with other EGF‐receptor (ErbB1) ligands, such as TGF‐α and HB‐EGF, produced increases in CSPG production similar to those observed with EGF. Treatment of astrocytes, however, with heregulin, which signals through other members of the EGF‐receptor family (ErbB2, ErbB3, ErbB4), did not induce CSPG upregulation. The specificity of activation through the ErbB1 receptor was further verified by using a selective antagonist (AG1478) to this tyrosine kinase receptor. Western blot analysis of astrocyte supernatant pre‐digested with chondroitinase ABC indicated the presence of multiple core proteins containing 4‐sulfated or 6‐sulfated chondroitin. To identify some of these CSPGs, Western blots were screened using antibodies to several known CSPG core proteins. These analyses showed that treatment of astrocytes with EGF increased phosphacan expression, whereas treatment with TGF‐β1 increased neurocan expression. Reverse transcription‐polymerase chain reaction (RT‐PCR) was used to examine the expression of these molecules in vivo, which result in increased expression of TGF‐β1, EGF‐receptor, neurocan, and phosphacan after injury to the brain. These data begin to elucidate some of the injury‐induced growth factors that regulate the expression of CSPGs which could be targeted in the future to modulate CSPG production after injury to the central nervous system. © 2005 Wiley‐Liss, Inc.
Results of the Bank’s survey of wage-setting in Belgian firms

The analysis presented is the outcome of a survey conducted by the Bank and forming the Belgian component of an initiative launched by the Wage Dynamics Network (WDN), in order to accompany the empirical analysis based on individual employees’ wage data obtained, for instance, from administrative data banks. The survey contains questions on the wage-setting process, the existence of downward rigidity and the reasons for it, the reaction of firms to shocks, and the frequency and timing of wage and price adjustments. The survey reveals that almost all firms in Belgium are covered by a sector agreement, and just over a quarter apply an additional collective wage agreement at the firm level. Such firm-level collective agreements are more common in large firms. The results also show that just over half of firms apply a wage indexation mechanism with a threshold index, while just under half operate in an environment where indexation takes place at fixed intervals. The latter system is more common in large firms, so that the weighted results indicate that this mechanism applies to the majority of employees. The level of wages of new employees depends mainly on what is specified in collective agreements and on the wage level of comparable employees in the firm. However, the wages which the firm actually pays to its staff may deviate from the pay scales specified in the sectoral agreements. In a significant number of firms, especially for white-collar workers and skilled staff, actual wages paid exceed the sectoral pay scales. Such a wage cushion, forming a buffer between the actual wages and the collectively agreed lower limits, is more common in large firms. Overall, firms seldom respond to adverse shocks by cutting basic wages or using alternative ways of reducing labour costs per employee. Certainly in large firms, costs are reduced mainly via the employment channel, i.e. by reducing the number of primarily permanent staff, and to a lesser extent temporary workers. Reductions in non-wage costs are also important, while variable pay components are only cut in a small number of cases. Only a quarter of firms state that they adjust their prices more than once a year. Time-dependent price adjustments, in which the time of the adjustment does not depend on economic conditions (as opposed to state-dependent adjustments), occur in 22 p.c. of firms and are noticeably common in the business service sector. Combined with the low frequency of price adjustments, this indicates price rigidity in that sector. The frequency and timing of wage adjustments are closely linked to the indexation mechanism applied. Most firms adjust their wages no more than once a year. Time-dependent wage adjustments in a specific month apply to 61 p.c. of firms, and – like price adjustments – wage adjustments are concentrated in the month of January. Another peak occurs in July, and there is some concentration at the beginning of the second and fourth quarters, particularly in the case of wage adjustments.
Recent advances of hybrid planar/NRD-guide technology for millimeter-wave integrated circuit design

In this paper, we look at different possibilities and advantages of our early proposed hybrid planar and nonradiative dielectric (NRD) guide technology in the design of various millimeter-wave circuits. First of all, an overview of the NRD guide technology progress is presented. It indicates that the hybrid planar/NRD-guide (HP/NRDG) technology provides a straightforward assembly of MMIC circuits with NRD-guide. To begin with, a simple fabrication technique for NRD-guide is described, which allows the fabrication of complex NRD circuits in a single step. Then, a new magic tee junction based on HP/NRDG technology is presented with measured results. New mode suppressor topologies compatible with the HP/NRDG technology are discussed for spurious waveguide modes, the LSE/sub 10/ mode and also the LSM/sub 10/ mode. Finally a discussion is made on different design possibilities of HP/NRDG power amplifier topologies. The present overview of some of our ongoing research work on the HP/NRDG technology suggests that the realization of a low-cost millimeter-wave transceiver is possible.
Commodity Concentration and Export Instability: The Choice of Concentration Measure and Analytical Framework

Conventionally, commodity concentration has been regarded as a major cause of export earnings instability in developing countries, the assumption being that such concentration reduces the chance that fluctuations in one direction in some exports will be offset by counterfluctuations or stability in earnings from other commodities. A considerable number of empirical studies have failed, however, to detect a significant, positive relationship between concentration and export instability. ' The purpose of this paper is twofold. First, I will examine whether the choice of index to measure concentration is a matter of secondary importance, a view that achieved considerable currency in the parallel literature on industrial concentration. Second, I will consider the performance of currently available concentration measures within a model specification substantially different from that typically used. My analysis of a sample of developing countries indicates that the choice of concentration measure is, in fact, important and that a shift to time series and away from crosssection analysis indicates a causal relationship between concentration and instability. Concentration and Instability In the conventional argument about the relationship between commodity concentration and instability, the concept of concentration embraces two basic dimensions; the relatively small number of commodities exported and the unequal distribution of commodity shares in total earnings. To reflect these dimensions, Hirschman, building on the work of Gini in connection with income distribution, devised what became the
Pattern separation and pattern completion in Alzheimer's disease: Evidence of rapid forgetting in amnestic mild cognitive impairment

Over the past four decades, the characterization of memory loss associated with Alzheimer's disease (AD) has been extensively debated. Recent iterations have focused on disordered encoding versus rapid forgetting. To address this issue, we used a behavioral pattern separation task to assess the ability of the hippocampus to create and maintain distinct and orthogonalized visual memory representations in patients with amnestic mild cognitive impairment (aMCI) and mild AD. We specifically used a lag‐based continuous recognition paradigm to determine whether patients with aMCI and mild AD fail to encode visual memory representations or whether these patients properly encode representations that are rapidly forgotten. Consistent with the rapid forgetting hypothesis of AD, we found that patients with aMCI demonstrated decreasing pattern separation rates as the lag of interfering objects increased. In contrast, patients with AD demonstrated consistently poor pattern separation rates across three increasingly longer lags. We propose a continuum that reflects underlying hippocampal neuropathology whereby patients with aMCI are able to properly encode information into memory but rapidly lose these memory representations, and patients with AD, who have extensive hippocampal and parahippocampal damage, cannot properly encode information in distinct, orthogonal representations. Our results also revealed that whereas patients with aMCI demonstrated similar behavioral pattern completion rates to healthy older adults, patients with AD showed lower pattern completion rates when we corrected for response bias. Finally, these behavioral pattern separation and pattern completion results are discussed in terms of the dual process model of recognition memory. © 2013 Wiley Periodicals, Inc.
Cooperation, harassment, and involuntary unemployment : an insider - outsider approach

The authors present a theory of involuntary unemployment which explains why the unemployed workers ("outsiders" ) are unable or unwilling to find jobs even though they are prepared to work for less than the prevailing wages of incumbent workers ("in siders"). The outsiders do not underbid the insiders since, were the y to do so, the insiders would withdraw cooperation from them, making their work unpleasant with harassment, and thereby reducing the prod uctivity and increasing the reservation wages of the underbidders. Th e resulting labor-turnover costs create economic rent which the insid ers tap in wage setting and, as a result, involuntary unemployment ma y arise. Copyright 1988 by American Economic Association.
Resistance of Human Cytomegalovirus to Cyclopropavir Maps to a Base Pair Deletion in the Open Reading Frame of UL97

ABSTRACT Human cytomegalovirus (HCMV) is a widespread pathogen in the human population, affecting many immunologically immature and immunocompromised patients, and can result in severe complications, such as interstitial pneumonia and mental retardation. Current chemotherapies for the treatment of HCMV infections include ganciclovir (GCV), foscarnet, and cidofovir. However, the high incidences of adverse effects (neutropenia and nephrotoxicity) limit the use of these drugs. Cyclopropavir (CPV), a guanosine nucleoside analog, is 10-fold more active against HCMV than GCV (50% effective concentrations [EC50s] = 0.46 and 4.1 μM, respectively). We hypothesize that the mechanism of action of CPV is similar to that of GCV: phosphorylation to a monophosphate by viral pUL97 protein kinase with further phosphorylation to a triphosphate by endogenous kinases, resulting in inhibition of viral DNA synthesis. To test this hypothesis, we isolated a CPV-resistant virus, sequenced its genome, and discovered that bp 498 of UL97 was deleted. This mutation caused a frameshift in UL97 resulting in a truncated protein that lacks a kinase domain. To determine if this base pair deletion was responsible for drug resistance, the mutation was engineered into the wild-type viral genome, which was then exposed to increasing concentrations of CPV. The results demonstrate that the engineered virus was approximately 72-fold more resistant to CPV (EC50 = 25.8 ± 3.1 μM) than the wild-type virus (EC50 = 0.36 ± 0.11 μM). We conclude, therefore, that this mutation is sufficient for drug resistance and that pUL97 is involved in the mechanism of action of CPV.
Chemical and Stress Resistances of Clostridium difficile Spores and Vegetative Cells

Clostridium difficile is a Gram-positive, sporogenic and anaerobic bacterium that causes a potentially fatal colitis. C. difficile enters the body as dormant spores that germinate in the colon to form vegetative cells that secrete toxins and cause the symptoms of infection. During transit through the intestine, some vegetative cells transform into spores, which are more resistant to killing by environmental insults than the vegetative cells. Understanding the inherent resistance properties of the vegetative and spore forms of C. difficile is imperative for the development of methods to target and destroy the bacterium. The objective of this study was to define the chemical and environmental resistance properties of C. difficile vegetative cells and spores. We examined vegetative cell and spore tolerances of three C. difficile strains, including 630Δerm, a 012 ribotype and a derivative of a past epidemic strain; R20291, a 027 ribotype and current epidemic strain; and 5325, a clinical isolate that is a 078 ribotype. All isolates were tested for tolerance to ethanol, oxygen, hydrogen peroxide, butanol, chloroform, heat and sodium hypochlorite (household bleach). Our results indicate that 630Δerm vegetative cells (630 spo0A) are more resistant to oxidative stress than those of R20291 (R20291 spo0A) and 5325 (5325 spo0A). In addition, 5325 spo0A vegetative cells exhibited greater resistance to organic solvents. In contrast, 630Δerm spores were more sensitive than R20291 or 5325 spores to butanol. Spores from all three strains exhibited high levels of resistance to ethanol, hydrogen peroxide, chloroform and heat, although R20291 spores were more resistant to temperatures in the range of 60–75°C. Finally, household bleach served as the only chemical reagent tested that consistently reduced C. difficile vegetative cells and spores of all tested strains. These findings establish conditions that result in vegetative cell and spore elimination and illustrate the resistance of C. difficile to common decontamination methods. These results further demonstrate that the vegetative cells and spores of various C. difficile strains have different resistance properties that may impact decontamination of surfaces and hands.
REFLETINDO SOBRE CRITÉRIOS DE QUALIDADE DA PESQUISA QUALITATIVA

E importante estabelecer e definir criterios que permitam a avaliacao da qualidade da pesquisa cientifica. Embora exista na literatura metodologica uma preocupacao em se discutir quais padroes devem ser adotados para garantir rigor nas investigacoes cientificas realizadas a partir de uma metodologia quantitativa, nota-se uma falta de consenso quando se trata da pesquisa qualitativa. Neste artigo pretende- se identificar e analisar os criterios propostos pelos textos especializados em pesquisa qualitativa e que sao sugeridos para a avaliacao da qualidade dos estudos elaborados segundo o paradigma interpretativo. Busca-se discutir esta questao no âmbito dos estudos qualitativos “basicos ou genericos” (Merriam, 1998; 2002) e propoe-se um conjunto minimo de criterios que auxiliem os pesquisadores a refletir sobre a qualidade deste tipo de investigacao. Sao estabelecidos alguns pontos fundamentais a serem observados: explicitacao cuidadosa da metodologia, congruencia entre as diferentes etapas do estudo, validade interna, possibili ade de transferencia dos resultados ualid stro dos dados. d ade do regi e q