Miracle-dz/UniFAR-FTUs huggingface dataset:
Lifestyle Fitness Coaching

Lifestyle fitness coaching is an emerging field in the health and fitness industry. Centered on an ongoing and guided process of dialogue, Lifestyle Fitness Coaching offers a systematic approach to help fitness professionals understand their clients' needs, interests, and personal orientations and use the information to direct clients toward achieving their health and personal goals. "Lifestyle Fitness Coaching" contains detailed information on coaching dialogues between the health fitness professional and the client, addressing issues such as the types of questions to ask, how to provide feedback effectively, and how to make referrals. The text includes useful information for guiding program development and learning activities that help readers understand the material and relate it to their situations. In addition, an accompanying CD-ROM contains a Matching Activities and Personal Styles (MAPS) Inventory, a validated questionnaire that clients complete to identify their likes and dislikes. The MAPS Inventory software then generates a report that coaches and clients can use to guide the coaching process. "Lifestyle Fitness Coaching" presents the necessary skills for professional development and offers a methodology for gathering and analyzing personal information about clients that enables coaches to engage in dialogue about the means and ends of clients' sport and fitness programming. With this text, professionals can do the following: -Learn the building blocks of information and skills for developing a career as a lifestyle fitness coach-Appreciate the skills and coaching processes necessary for communicating with clients-Engage clients in an ongoing process of dialogue informed by comprehensive fitness-related data concerning clients' needs, interests, and background-Reinforce their understanding and practice their application of the skills presented-Help clients develop profiles of personal style and related exercise optionsThis text teaches health fitness professionals how to step into the arena of lifestyle fitness coaching to motivate, guide, inform, and support their clients' personal change processes. The book delineates the bounds of care and advice that coaches should give and helps coaches aid clients in strategizing, planning, and implementing self-change and personal improvement programs. Issues are explored including the coaching relationship; goals, boundaries, and ethics in coaching; coaching stages and processes; and coaching skills. The book also examines assessments, applications, and opportunities and directions in lifestyle fitness coaching.As such, "Lifestyle Fitness Coaching" is an invaluable resource for health fitness professionals who want to expand their skills and move toward more enriching and rewarding interactions with their clients.
L’influence d’innovations pédagogiques sur le profil motivationnel et le choix de stratégies d’apprentissage d’étudiantes et d’étudiants d’une faculté d’ingénierie

L’etude vise a degager une typologie des caracteristiques motivationnelles ainsi que des strategies d’apprentissage utilisees par les etudiants en fonction de trois approches pedagogiques, soit l’expose, l’approche par projet et l’apprentissage individualise sur le web. Un questionnaire a ete rempli par 494 etudiants du premier cycle universitaire. L’analyse des correspondances et de classification montre que ce sont l’approche par projet et l’expose magistral qui suscitent le plus la motivation, alors que l’approche de l’apprentissage individualisee sur le web est celle qui en suscite le moins. L’approche individualisee et l’expose magistral incitent davantage le recours aux strategies de memorisation, de repetition et d’organisation, alors qu’on a davantage recours aux strategies de regulation de l’effort et de gestion du temps dans les cours-projets. Une discussion tente d’expliquer les differences observees.
Structural Determinants of HERG Channel Block by Clofilium and Ibutilide

Block of human ether-a-go-go related gene (HERG) K+ channels by a variety of medications has been linked to acquired long QT syndrome, a disorder of cardiac repolarization that predisposes to lethal arrhythmias. The drug-binding site is composed of residues that face into the central cavity of the channel. Two aromatic residues located on the S6 domain (Tyr652 and Phe656) are particularly important structural determinants of drug block. The role of pore helix residues (Thr623, Ser624, Val625) is less clear. In this study, we compared the pharmacological properties of two structurally related compounds, ibutilide and clofilium. Both compounds are charged amines with a single phenyl ring. Clofilium, a chlorobenzene derivative, is a potent blocker of HERG channels, but has a remarkably slower time course for recovery from block than ibutilide, a methanesulfonanilide. The difference in the rate of recovery from block can be explained simply by variation in drug trapping. There is little recovery from clofilium block with D540K HERG channels that permit untrapping at hyperpolarized potentials. Alanine-scanning mutagenesis of the S6 domain and a portion of the pore helix revealed that the binding site residues were the same for both compounds. However, S624A, located at the base of the pore helix, was the only HERG mutation that enabled rapid recovery from clofilium block. In summary, the pore helix residues are important components of the HERG drug binding site, and may be particularly important for drugs with polar substituents, such as a halogen (e.g., clofilium) or a methanesulfonamide (e.g., ibutilide).
Cadherin-10 Maintains Excitatory/Inhibitory Ratio through Interactions with Synaptic Proteins

Appropriate excitatory/inhibitory (E/I) balance is essential for normal cortical function and is altered in some psychiatric disorders, including autism spectrum disorders (ASDs). Cell-autonomous molecular mechanisms that control the balance of excitatory and inhibitory synapse function remain poorly understood; no proteins that regulate excitatory and inhibitory synapse strength in a coordinated reciprocal manner have been identified. Using super-resolution imaging, electrophysiology, and molecular manipulations, we show that cadherin-10, encoded by CDH10 within the ASD risk locus 5p14.1, maintains both excitatory and inhibitory synaptic scaffold structure in cultured cortical neurons from rats of both sexes. Cadherin-10 localizes to both excitatory and inhibitory synapses in neocortex, where it is organized into nanoscale puncta that influence the size of their associated PSDs. Knockdown of cadherin-10 reduces excitatory but increases inhibitory synapse size and strength, altering the E/I ratio in cortical neurons. Furthermore, cadherin-10 exhibits differential participation in complexes with PSD-95 and gephyrin, which may underlie its role in maintaining the E/I ratio. Our data provide a new mechanism whereby a protein encoded by a common ASD risk factor controls E/I ratios by regulating excitatory and inhibitory synapses in opposing directions. SIGNIFICANCE STATEMENT The correct balance between excitatory/inhibitory (E/I) is crucial for normal brain function and is altered in psychiatric disorders such as autism. However, the molecular mechanisms that underlie this balance remain elusive. To address this, we studied cadherin-10, an adhesion protein that is genetically linked to autism and understudied at the cellular level. Using a combination of advanced microscopy techniques and electrophysiology, we show that cadherin-10 forms nanoscale puncta at excitatory and inhibitory synapses, maintains excitatory and inhibitory synaptic structure, and is essential for maintaining the correct balance between excitation and inhibition in neuronal dendrites. These findings reveal a new mechanism by which E/I balance is controlled in neurons and may bear relevance to synaptic dysfunction in autism.
Ramsey numbers of degenerate graphs

A graph is $d$-degenerate if all its subgraphs have a vertex of degree at most $d$. We prove that there exists a constant $c$ such that for all natural numbers $d$ and $r$, every $d$-degenerate graph $H$ of chromatic number $r$ with $|V(H)| \ge 2^{d^22^{cr}}$ has Ramsey number at most $2^{d2^{cr}} |V(H)|$. This solves a conjecture of Burr and Erdős from 1973.
“I'm ashamed because of you, so please, don't do that!”: Reactions to deviance as a protection against a threat to social image

The present research investigated the role that threat to social image and self‐conscious emotions play in reaction to deviance. In three studies, participants were invited to imagine themselves in a situation in which they were bystanders of a deviant behavior. We manipulated the threat to the in‐group’s social image through the deviant group membership (Study 1), the visibility of the deviant behavior to a third party (Study 2), and the stereotype salience of the deviant behavior (Study 3). Social image concerns, emotional reactions, and intention of sanctioning the deviant were measured. The results revealed that the situations in which the threat to the social image of the group was high provoked the greater intentions to sanction the deviant. Moreover, intentions were accounted for by the more intense shame and embarrassment (but not guilt) reported by the participants when faced with a group‐threatening situation. The findings indicate that reactions to deviance are highly dependent on the damage caused to the group’s social image and on self‐conscious emotions. Copyright © 2011 John Wiley & Sons, Ltd.
Systemic sclerosis is associated with specific alterations in gastrointestinal microbiota in two independent cohorts

Objective To compare faecal microbial composition in patients with systemic sclerosis (SSc) from 2 independent cohorts with controls and to determine whether certain genera are associated with SSc-gastrointestinal tract (GIT) symptoms. Design Adult patients with SSc from the University of California, Los Angeles (UCLA) and Oslo University Hospital (OUH) and healthy controls participated in this study (1:1:1). All participants provided stool specimens for 16S rRNA sequencing. Linear discriminant analysis effect size demonstrated genera with differential expression in SSc. Differential expression analysis for sequence count data identified specific genera associated with GIT symptoms as assessed by the GIT 2.0 questionnaire. Results The UCLA-SSc and OUH-SSc cohorts were similar in age (52.1 and 60.5 years, respectively), disease duration (median (IQR): 6.6 (2.5–16.4) and 7.0 (1.0–19.2) years, respectively), gender distribution (88% and 71%, respectively), and GIT symptoms (mean (SD) total GIT 2.0 scores of 0.7 (0.6) and 0.6 (0.5), respectively). Principal coordinate analysis illustrated significant microbial community differences between SSc and controls (UCLA: p=0.001; OUH: p=0.002). Patients with SSc had significantly lower levels of commensal genera deemed to protect against inflammation, such as Bacteroides (UCLA and OUH), Faecalibacterium (UCLA), Clostridium (OUH); and significantly higher levels of pathobiont genera, such as Fusobacterium (UCLA), compared with controls. Increased abundance of Clostridium was associated with less severe GIT symptoms in both cohorts. Conclusions The present analysis detected specific aberrations in the lower GIT microbiota of patients with SSc from 2 geographically and ethnically distinct cohorts. These findings suggest that GIT dysbiosis may be a pathological feature of the SSc disease state.
Proteomics of Human Neurodegenerative Diseases

The technology, experimental approaches, and bioinformatics that support proteomic research are evolving rapidly. The application of these new capabilities to the study of neurodegenerative diseases is providing insight into the biochemical pathogenesis of neurodegeneration as well as fueling major efforts in biomarker discovery. Here, we review the fundamentals of commonly used proteomic approaches and the outcomes of these investigations with autopsy and cerebrospinal fluid samples from patients with neurodegenerative diseases.
Pattern of pediatric poisoning in the east Karadeniz region between 2002 and 2006: increased suicide poisoning

In the present study, 386 patients with the diagnosis of poisoning admitted to the Pediatric Emergency Unit of Farabi Hospital of Medical Faculty of Karadeniz Technical University between January 2002 and December 2006 were retrospectively evaluated with respect to gender, age, cause of poisoning, type of substance used, route of exposure, reason for the intake, signs and symptoms, time of referral to the hospital, hospitalization period, and prognosis. The age group of most poisoning cases was <5 years of age and constituted 51% (n = 197) of all cases. The main toxic agent was drugs (70.2%), followed by foods (8.8%), rodenticides (7%), insecticides/pesticides (4.9%), and carbon monoxide (4.7%). In childhood poisonings, accidental drug poisoning was frequent in toddlers, whereas suicidal poisoning was frequent in adolescents. The suicidal poisoning rate was 23.8% among all poisoning patients, and 98.9% of these patients were adolescents. The suicidal poisoning rates for males and females were 30% and 70%, respectively. An increase in suicidal and inhalation poisonings was observed when compared with previous studies that have been conducted in the same region. The results of the present study suggest that poisonings still represents an important health problem that could be prevented by safe drug storage at home, as well as parental education on adolescence issues, particularly those regarding females.
Through Glass Via (TGV) disc loaded monopole antennas for millimeter-wave wireless interposer communication

A monopole antenna loaded with a circular disc is integrated on a glass interposer layer for millimeter-wave wireless communication applications. A Through Glass Via (TGV) is used as a main radiator and the circular disc is for a impedance matching. An omnidirectional radiation pattern formed by the monopole antenna allows in-plane wireless communication whose distance is much larger than 1cm. This can solve problems such as cross talk and time delay caused by the conventional wire bonding approach. A 77 GHz (W-band) antenna is designed and fabricated as a prototype on a glass substrate. The simulated peak gain of the antenna is 1.23 dBi. Also, as this antenna concept is scalable, the same architecture has been exercised for a 5.8 GHz industrial, scientific and medical, ISM band application. The design, fabrication, and characterization are detailed. The measured results of the return loss and radiation pattern agree well with the simulation results.
Blood pressure and hemodynamic responses to an acute sodium load in humans.

The purpose of this study was to investigate the acute blood pressure (BP) and hemodynamic effects of sodium chloride (3% intravenous solution). Although many studies link a change in dietary sodium to a change in BP, few consider the effects of sodium concentration in the blood on BP. We hypothesized that an intravenous sodium load would increase BP, and we quantified alterations in cardiac output (Qc) and peripheral vascular resistance (PVR). Thirteen subjects (age 27 +/- 2 yr) underwent a 60-min 3% saline infusion (0.15 ml.kg(-1). min(-1)). BP was assessed on a beat-to-beat basis with a Finometer, Qc was assessed via the CO(2) rebreathing technique, and PVR was derived. Serum sodium and osmolality increased, and hematocrit declined during the infusion (ANOVA, P < 0.01). Mean arterial pressure (MAP) increased continuously during the infusion from 81.8 +/- 3.4 to 91.6 +/- 3.6 mmHg (ANOVA, P < 0.01). BP responsiveness to sodium was expressed as the slope of the serum sodium-MAP relationship and averaged 1.75 +/- 0.34 mmHg.mmol(-1). l(-1). BP responsiveness to the volume change was expressed as the slope of the hematocrit-MAP relationship and averaged -2.2 +/- 0.35 mmHg/%. The early change in MAP was mediated by an increase in Qc and the late change by an increase in PVR (P < 0.05), corresponding to a 30% increase in plasma norepinephrine. In conclusion, an acute infusion of hypertonic saline was effective in increasing BP, and both sodium and volume appear to be involved in this increase; acute BP responsiveness to serum sodium can be quantified using a MAP-sodium plot.
AN X-RAY SURVEY OF THE YOUNG STELLAR POPULATION OF THE LYNDS 1641 AND IOTA ORIONIS REGIONS

We present an XMM-Newton survey of the part of the Orion A cloud south of the Orion Nebula. This survey includes the Lynds 1641 (L1641) dark cloud, a region of the Orion A cloud with very few massive stars and hence a relatively low ambient UV flux, and the region around the O9 III star ι Orionis. In addition to proprietary data, we used archival XMM data of the Orion Nebula Cluster (ONC) to extend our analysis to a major fraction of the Orion A cloud. We have detected 1060 X-ray sources in L1641 and the ι Ori region. About 94% of the sources have Two Micron All Sky Survey and Spitzer counterparts, 204 and 23 being Class II and Class I or protostar objects, respectively. In addition, we have identified 489 X-ray sources as counterparts to Class III candidates, given they are bright in X-rays and appear as normal photospheres at mid-IR wavelengths. The remaining 205 X-ray sources are likely distant active galactic nuclei or other galactic sources not related to Orion A. We find that Class III candidates appear more concentrated in two main clusters in L1641. The first cluster of Class III stars is found toward the northern part of L1641, concentrated around ι Ori. The stars in this cluster are more evolved than those in the Orion Nebula. We estimate a distance of 300–320 pc for this cluster showing that it is in the foreground of the Orion A cloud. Another cluster rich in Class III stars is located in L1641 South and appears to be a slightly older cluster embedded in the Orion A cloud. Furthermore, other evolved Class III stars are found north of the ONC toward NGC 1977.
Limited Asset Markets Participation, Monetary Policy and (Inverted) Keynesian Logic

This paper incorporates limited asset markets participation in dynamic general equilibrium and develops a simple analytical framework for monetary policy analysis. Aggregate dynamics and stability properties of an otherwise standard business cycle model depend nonlinearly on the degree of asset market participation. While 'moderate' participation rates strengthen the role of monetary policy, low enough participation causes an inversion of results dictated by ('Keynesian') conventional wisdom. The slope of the 'IS' curve changes sign, the 'Taylor principle' is inverted, optimal welfare-maximizing monetary policy requires a passive policy rule and the effects and propagation of shocks are changed. The conditions for these results to hold are relatively mild compared to some existing empirical evidence. Our results may help explain the 'Great Inflation' and justify Fed behavior during that period.
Homology Models of the Yersinia Pseudotuberculosis and Yersinia Pestis General Porins and Comparative Analysis of Their Functional and Antigenic Regions

Abstract The amino acid sequences of the Yersinia pseudotuberculosis porin (YPS) and Y. pestis porin (YPT) have recently deduced but their three-dimensional structures were not known. These sequences were analyzed using the servers 3D-PSSM and PredPort. The YPS and YPT porins were shown to have a high degree of identity (above 50%) in primary and secondary structures. The three-dimensional models of the Yersinia pseudotuberculosis porin (YPS) and Y. pestis porin (YPT) were obtained using the homology modeling approach, SWISS-MODEL Protein Modeling Server and 3-D structure of PhoE porin from E. coli as template. The superposition of the Ca-atoms of the monomers of the Yersinia porins and PhoE porin gave a root mean square deviations of 0.47 A and 0.43 A for YPS and YPT respectively. Yersinia porins were found to be very similar in their three-dimentional structure to other non-specific enterobacterial porins, having the same features of overall fold and disposition of loop L3. The intrinsic structures of the monomer pores of YPS and YPT were investigated and their conductances were predicted with the program HOLE. The good correspondence between the theoretical and experimental magnitudes of YPS conductance was found. The Yersinia porins were determined to be unusual in containing the substitution, Glu replaced by Val, in a highly conserved pentapeptide (Pro-Glu-Phe-Gly-Gly-Asp), located in the loop L3 tip that disturbs the functionally important cluster of the acidic amino acids in the constriction site. Comparative analysis of structural organization of YPS and E. coli OmpF porin in the regions involved in subunit association and pore lumen was performed. The YPS porin functional properties were predicted. The differences between these porins in polar interactions playing a signifiant role in stabilization of the porin trimers were found and discussed in term of the variations in trimer stability. The Yersinia porins were shown to have the highest degree of the structural similarity. The differences between the porins were observed in their external loops. Their loops L6 and loops L8 showed 71.4 and 52.9% of sequence identity, respectively. The arrangement of charged residues clustered in the channel external vestibule of these porins was found to be also different sugesting the possible differences in their functional properties. The surface exposed regions of Yersinia porins involved in their potential sequential antigenic determinants were compared. The structural basis of their cross reactivity and antigenic differences is discussed.
Interference-throughput tradeoff in dynamic spectrum access: Analysis based on discrete-time queuing subjected to bursty preemption

This article considers the issue of dynamic spectrum access in time domain, in which the secondary user seeks spectrum vacancy between bursty transmissions of the primary user to communicate. Since spectrum sensing and data transmission can not be done simultaneously in the same band, the secondary user should employ the sense-then-transmit strategy to detect the presence of primary user before accessing the licensed band. We model the behavior of the secondary user as a discrete-time queuing subjected to bursty preemption, which is an abstraction of temporal channel unavailability due to the random presence of the primary user. We formulate an interference-throughput tradeoff problem under the discrete-time queuing framework, and find the optimal slot duration to maximize the throughput of the secondary user, yet to ensure the Primary Interfered Time Ratio (PITR) is less than a tolerable threshold. Finally, the computer simulation results validate our theoretical approach.
Diverse corrugation pattern in radially shrinking carbon nanotubes

Stable cross sections of multiwalled carbon nanotubes subjected to electron-beam irradiation are investigated in the realm of the continuum mechanics approximation. The self-healing nature of sp2 graphitic sheets implies that selective irradiation of the outermost walls causes their radial shrinkage with the remaining inner walls undamaged. The shrinking walls exert high pressure on the interior part of nanotubes, yielding a wide variety of radial-corrugation patterns (i.e. circumferentially wrinkling structures) in the cross section. All corrugation patterns can be classified into two deformation phases for which the corrugation amplitudes of the innermost wall differ significantly.