Miracle-dz/UniFAR-FTUs huggingface dataset:
Factors Associated with Dental Pain in Mexican Schoolchildren Aged 6 to 12 Years

Objective To identify dental pain prevalence and associated factors in Mexican schoolchildren. Methods This cross-sectional study included 1,404 schoolchildren aged 6 to 12 years from public schools in the city of Pachuca de Soto, Hidalgo, Mexico. Data were collected through a questionnaire that addressed sociodemographic and socioeconomic factors, eating and dental hygiene habits, and behavior variables. The dependent variable was self-reported dental pain in the 12 months prior to the survey. Data were analyzed using nonparametric statistics and a binary logistical regression model. Results Dental pain prevalence among the studied children was 49.9%. The variables associated in the final model (p < 0.05) were younger mother's age, higher socioeconomic level, absence of an automobile in the home, fried food, fruit intake, lower tooth brushing frequency, never having used mouthwash or not knowing about it, and parents/guardians with regular to high levels of knowledge about oral health and a regular or good/very good perception of their child's oral health. Conclusions One in two children in the study had experienced dental pain in the twelve months prior to the survey. The association of socioeconomic variables with dental pain suggested inequalities among the children in terms of oral health.
The DEAD-box helicase Mss116 plays distinct roles in mitochondrial ribogenesis and mRNA-specific translation

Abstract Members of the DEAD-box family are often multifunctional proteins involved in several RNA transactions. Among them, yeast Saccharomyces cerevisiae Mss116 participates in mitochondrial intron splicing and, under cold stress, also in mitochondrial transcription elongation. Here, we show that Mss116 interacts with the mitoribosome assembly factor Mrh4, is required for efficient mitoribosome biogenesis, and consequently, maintenance of the overall mitochondrial protein synthesis rate. Additionally, Mss116 is required for efficient COX1 mRNA translation initiation and elongation. Mss116 interacts with a COX1 mRNA-specific translational activator, the pentatricopeptide repeat protein Pet309. In the absence of Mss116, Pet309 is virtually absent, and although mitoribosome loading onto COX1 mRNA can occur, activation of COX1 mRNA translation is impaired. Mutations abolishing the helicase activity of Mss116 do not prevent the interaction of Mss116 with Pet309 but also do not allow COX1 mRNA translation. We propose that Pet309 acts as an adaptor protein for Mss116 action on the COX1 mRNA 5΄-UTR to promote efficient Cox1 synthesis. Overall, we conclude that the different functions of Mss116 in the biogenesis and functioning of the mitochondrial translation machinery depend on Mss116 interplay with its protein cofactors.
A Day-Ahead Forecasting Model for Probabilistic EV Charging Loads at Business Premises

Focusing on every individual electric vehicle (EV) while optimally charging a significant number of EV units at the workplace is normally computationally burdensome. Such charging optimization requires not only a long runtime but also a large CPU memory due to numerous decision variables involved. This paper develops a new combined state of charge (SOC) based methodology to calculate day-ahead combined probabilistic charging loads for a large number of EV units. Here, several models are proposed to estimate different combined statistical parameters based on historical data. The proposed methodology determines the transition of the combined SOC distribution of EV units from one timeslot to the next using these estimated parameters. Various strategies of SOC-based charging (e.g., unfair and fair modes) are investigated to control EV loads. Numerical results show that the proposed SOC-based charging can reduce the number of decision variables significantly, and require less computational time and memory accordingly.
Residual Compressive Stress-Strain Relationship for Concrete Subjected to Elevated Temperatures

This study attempts to investigate the post-fire residual stress-strain behaviour of unconfined plain and fibrous concretes under axial compression. The experimental variables of the study were concrete strength levels, volume fractions of flat crimped steel fibres and polypropylene fibres, inclusion of hybrid fibres and temperature of exposure. A total of 147 cylindrical specimens (150 x 450 mm) were cast and tested under this study. The specimens were first exposed to temperatures ranging from room temperature to 800°C and then tested under uni-axial compression after cooling to obtain complete residual stress-strain response. Based on the test data obtained, a simple empirical model is proposed to describe the complete residual stress-strain relationships of plain and fibre reinforced concrete after exposure at elevated temperatures. Important observations have been made in the paper about the influence of temperature on various mechanical properties namely strength, stress-strain curves, compressive t.
Hearing Loss in Persons Exposed and not Exposed to Occupational Noise.

OBJECTIVE This study aimed to compare hearing loss in individuals at risk and those not at risk for occupational noise and to compare working loss by gender. MATERIALS AND METHODS The analysis used data from a current Czech Ministry of Health grant project called Epidemiological and Genetic Study of the Frequency of Hearing Loss (2011 to 2015; NT12246-5/2011). The analyzed sample comprised 4988 participants. Hearing was tested using pure-tone threshold audiometry, tympanometry, and measurement of the stapedius reflex. RESULTS Females at risk and those not at risk for occupational noise who were younger than 44 years and older than 75 years were found to have no statistically significant differences at any pure-tone threshold audiometry frequency. In females aged 45 to 74 years, statistically significant differences were found. In males, hearing loss was observed as early as 18 years of age. When comparing males and females at no risk for occupational noise, there were no statistically significant differences at any of the frequencies in those younger than 29 years. In females aged 30 years or older, statistically significant differences were observed at various frequencies in all age groups. When comparing males and females at risk for occupational noise, statistically significant differences were more frequent than in employees not exposed to noise. CONCLUSION Hearing loss in females does not significantly vary depending on occupational exposure. The opposite is true for males. However, the maximum differences in mean levels did not exceed 10 dB. It is therefore clear that noise is a preventable factor, and the use of personal protective equipment is warranted.
A Structural Equation Model Analysis of Relationships among ENSO, Seasonal Descriptors and Wildfires

Seasonality drives ecological processes through networks of forcings, and the resultant complexity requires creative approaches for modeling to be successful. Recently ecologists and climatologists have developed sophisticated methods for fully describing seasons. However, to date the relationships among the variables produced by these methods have not been analyzed as networks, but rather with simple univariate statistics. In this manuscript we used structural equation modeling (SEM) to analyze a proposed causal network describing seasonality of rainfall for a site in south-central Florida. We also described how this network was influenced by the El Niño-Southern Oscillation (ENSO), and how the network in turn affected the site’s wildfire regime. Our models indicated that wet and dry seasons starting later in the year (or ending earlier) were shorter and had less rainfall. El Niño conditions increased dry season rainfall, and via this effect decreased the consistency of that season’s drying trend. El Niño conditions also negatively influenced how consistent the moistening trend was during the wet season, but in this case the effect was direct and did not route through rainfall. In modeling wildfires, our models showed that area burned was indirectly influenced by ENSO via its effect on dry season rainfall. Area burned was also indirectly reduced when the wet season had consistent rainfall, as such wet seasons allowed fewer wildfires in subsequent fire seasons. Overall area burned at the study site was estimated with high accuracy (R 2 score = 0.63). In summary, we found that by using SEMs, we were able to clearly describe causal patterns involving seasonal climate, ENSO and wildfire. We propose that similar approaches could be effectively applied to other sites where seasonality exerts strong and complex forcings on ecological processes.
The millimeter wave spectrum of methyl cyanate: a laboratory study and astronomical search in space.

AIMS The recent discovery of methyl isocyanate (CH3NCO) in Sgr B2(N) and Orion KL makes methyl cyanate (CH3OCN) a potential molecule in the interstellar medium. The aim of this work is to fulfill the first requirement for its unequivocal identification in space, i.e. the availability of transition frequencies with high accuracy. METHODS The room-temperature rotational spectrum of methyl cyanate was recorded in the millimeter wave domain from 130 to 350 GHz. All rotational transitions revealed A-E splitting owing to methyl internal rotation and were globally analyzed using the ERHAM program. RESULTS The data set for the ground torsional state of methyl cyanate exceeds 700 transitions within J″ = 10 - 35 and [Formula: see text] and newly derived spectroscopic constants reproduce the spectrum close to the experimental uncertainty. Spectral features of methyl cyanate were then searched for in Orion KL, Sgr B2(N), B1-b, and TMC-1 molecular clouds. Upper limits to the column density of methyl cyanate are provided.
A Two-Year Longitudinal Assessment of Ophthalmologists’ Perceptions after Implementing an Electronic Health Record System

Summary Objectives To understand the attitudes and perceptions of ophthalmologists toward an electronic health record (EHR) system, before and after its clinical implementation. Methods Ophthalmologists at a single large academic ophthalmology department were surveyed longitudinally before and after implementation of a new EHR system. The survey measured ophthalmologists’ attitudes toward implementation of a new EHR. Questions focused on satisfaction, efficiency, and documentation. All attending physicians (between 56 and 61 at various time points) in the University of Michigan Department of Ophthalmology and Visual Sciences were surveyed. We plotted positive responses to survey questions and assessed whether perceptions followed a J-curve with an initial decrease followed by an increase surpassing pre-implementation levels. Results Survey responses were received from 32 (52%) ophthalmologists pre-implementation, and 28 (46%) at 3 months, 35 (57%) at 7 months, 40 (71%) at 13 months and 39 (67%) at 24 months post-implementation. After EHR implementation respondents were more likely to express concerns about their ability to create high-quality documentation (p<0.01) and the impact of an electronic health record on meaningful patient interaction (p<0.01). Physicians did not report a significant change in the amount of time spent documenting outside of regular clinical work hours (p=0.54) or on their clinic efficiency and workflow (p=0.97). There was no significant change in overall job satisfaction during the study period (p=0.69). We did not observe a J-curve for any of the survey responses analyzed. Conclusions As ophthalmology practices continue to transition to EHRs, adapting them to their specific culture and needs is important to maintain efficiency and user satisfaction. This study identifies areas of concern to ophthalmologists that may be addressed through education of physicians and customization of software as other practices move forward with EHR implementation. Citation: Ehrlich JR, Michelotti M, Blachley TS, Zheng K, Couper MP, Greenberg GM, Kileny S, Branford GL, Hanauer DA, Weizer JS. A two-year longitudinal assessment of ophthalmologists’ perceptions after implementing an electronic health record system.
Long time dynamics for the one dimensional non linear Schrödinger equation

In this article, we first present the construction of Gibbs measures associated to nonlinear Schrodinger equations with harmonic potential. Then we show that the corresponding Cauchy problem is globally well-posed for rough initial conditions in a statistical set (the support of the measures). Finally, we prove that the Gibbs measures are indeed invariant by the flow of the equation. As a byproduct of our analysis, we give a global well-posedness and scattering result for the $L^2$ critical and super-critical NLS (without harmonic potential).
Properties of Wool/PET Composite Yarns

This paper reports an investigation of the differences in structures and mechanical properties of two kinds of composite yarns and of conventional two-ply staple yarns. The cross section of one composite yarns (Sirofil) shows a circular shape, which is similar to the structure of single spun yarns and to the helical geometry line of two-ply yarns. The other composite yarn structure (twisted ring spun singles yarns with filaments) is similar to that of two-ply yams. The tensile properties of composite yarns mainly depend on the tensile properties of the filaments, and their tenacity is higher than that of two-ply wool/PET staple fiber yams. The bending rigidity of these two kinds of composite yams is lower than that of two-ply staple fiber yams. Wool/PET composite yarns show higher residual torque than conventional two-ply staple yarns, and the reason is their structure and lower torque-relaxation.
Embedded electro-conductive yarn for shape sensing of soft robotic manipulators

Flexible soft and stiffness-controllable surgical manipulators enhance the manoeuvrability of surgical tools during Minimally Invasive Surgery (MIS), as opposed to conventional rigid laparoscopic instruments. These flexible and soft robotic systems allow bending around organs, navigating through complex anatomical pathways inside the human body and interacting inherently safe with its soft environment. Shape sensing in such systems is a challenge and one essential requirement for precise position feedback control of soft robots. This paper builds on our previous work integrating multiple optical fibres into a soft manipulator to estimate the robot's pose using light intensity modulation. Here, we present an enhanced version of our embedded bending/shape sensor based on electro-conductive yarn. The new system is miniaturised and able to measure bending behaviour as well as elongation. The integrated yarn material is helically wrapped around an elastic strap and protected inside a 1.5mm outer-diameter stretchable pipe. Three of these resulting stretch sensors are integrated in the periphery of a pneumatically actuated soft manipulator for direct measurement of the actuation chamber lengths. The capability of the sensing system in measuring the bending curvature and elongation of the arm is evaluated.
Comparative Effectiveness of Resection vs Surveillance for Pancreatic Branch Duct Intraductal Papillary Mucinous Neoplasms With Worrisome Features

Importance The 2012 international consensus guidelines defined a subcategory of pancreatic branch duct intraductal papillary mucinous neoplasms with “worrisome features,” which may be followed with close surveillance. However, given the poor prognosis of invasive malignancy, the role of early, upfront resection requires further investigation. Objective To compare the utility of upfront resection vs long-term surveillance. We hypothesized that surveillance of these cystic neoplasms would offer greater long-term utility. Design, Setting, and Participants A Markov decision analysis model was constructed to estimate and compare 2 management strategies: early resection and long-term surveillance. Estimates for the utility of outcomes, probabilities of transitions between disease states, and probabilities of surgical morbidity were derived from a literature review of articles published between 1997 and 2014. The comparative effectiveness model’s variable estimates were based on data published predominantly by high-volume, tertiary referral centers. Model probability variable estimates were derived from large, retrospective, single-institution reports. For utility variables, estimates derived from studies using standard-gamble or time-tradeoff methods were given greater weight. Main Outcomes and Measures Expected utility was measured in terms of quality-adjusted life years using 3% annual discount. Probabilistic and 1-way sensitivity analyses were performed to assess the potential effects of uncertainty in estimates of key model variables. Results Early resection yielded 11.63 quality-adjusted life-years during 20 years of follow-up compared with 11.06 for surveillance. Probabilistic sensitivity analysis indicated that resection has a 94% likelihood of being more effective than surveillance. Early resection obtained greater utility only if each of the following criteria are met: life expectancy is at least 18 years, surgical mortality is less than 4.3%, and baseline preoperative utility is at least 0.78. Additional drivers of the model outcomes include the rate of progression from worrisome to high-risk features and the likelihood of finding cancer on resection for neoplasms with high-risk stigmata. Conclusions and Relevance Early resection compares favorably with surveillance in the management of branch duct intraductal papillary mucinous neoplasms with worrisome features. However, careful consideration of patient factors and surgeon outcomes is imperative.
CT Features of Ovarian Tumors: Defining Key Differences Between Serous Borderline Tumors and Low-Grade Serous Carcinomas.

OBJECTIVE The objective of our study was to investigate whether the CT features of serous borderline tumors (SBTs) differ from those of low-grade serous carcinomas (LGSCs) and to evaluate if mutation status is associated with distinct CT phenotypes. MATERIALS AND METHODS This retrospective study included 59 women, 37 with SBT and 22 with LGSC, who underwent CT before primary surgical resection. Thirty of 59 patients were genetically profiled. Two radiologists (readers 1 and 2) independently and retrospectively reviewed CT examinations for qualitative features and quantified total tumor volumes (TTVs), solid tumor volumes (STVs), and solid proportion of ovarian masses. Univariate and multivariate associations of the CT features with histopathologic diagnoses and mutations were evaluated, and interreader agreement was determined. RESULTS At multivariate analysis, the presence of bilateral ovarian masses (p = 0.03), the presence of peritoneal disease (PD) (p = 0.002), and higher STV of ovarian masses (p = 0.002) were associated with LGSC. The presence of nodular PD pattern (p < 0.001 each reader) and the presence of PD calcifications (reader 1, p = 0.02; reader 2, p = 0.003) were associated with invasive peritoneal lesions (i.e., LGSC). The presence of bilateral ovarian masses (p = 0.04 each reader), PD (reader 1, p = 0.01; reader 2, p = 0.004), and higher STV (p = 0.03 for each reader) were associated with the absence of BRAF mutation (i.e., wild type [wt]-BRAF). CONCLUSION The CT features of LGSCs were distinct from those of SBTs. The CT manifestations of LGSC and the wt-BRAF phenotype were similar.
Cluster Headache: Conventional Pharmacological Management

Cluster headache pain is very intense, usually increases in intensity very rapidly from onset, and attacks are often frequent. These clinical features result in significant therapeutic challenges. The most effective pharmacological treatment options for acute cluster attack include subcutaneous sumatriptan, 100% oxygen, and intranasal zolmitriptan. Subcutaneous or intramuscular dihydroergotamine and intranasal sumatriptan are additional options. Transitional therapy is applicable mainly for patients with high‐frequency (>2 attacks per day) episodic cluster headache, and options include short courses of high‐dose oral corticosteroids, dihydroergotamine, and occipital nerve blocks with local anesthetic and steroids. Prophylactic therapy is important both for episodic and chronic cluster headache, and the main options are verapamil and lithium. Verapamil is drug of first choice but may cause cardiac arrhythmias, and periodic electrocardiograms (EKGs) during dose escalation are important. Many other drugs are also in current use, but there is an insufficient evidence base to recommend them.
On identifying potential direct marketing consumers using adaptive boosted support vector machine

Identifying potential consumers for direct marketing to very large data is a difficult and impossible task to do manually. Therefore, the machine learning approach needs to help analyze the data to contribute in determining the marketing strategy policy. In this paper, vector machine support methods using the Adaboost algorithm are investigated to classify potential customers for direct marketing of large bank data marketing. The adaboost algorithm aims to build a better model than the model generated from a single classifier. Data obtained from UCI machine learning repository. Total data is processed as many as 9280 data with the number of attributes of 20 classes and 1 target class. Training data and test data are divided into 70% and 30%. This classification predicts the prospects for a deposit subscription. The results show that the SVM method using Adaboost algorithm obtained accuracy is 95.07% and the sensitivity is 91.65% higher than the ordinary SVM approach.
Tocotrienol-Adjuvanted Dendritic Cells Inhibit Tumor Growth and Metastasis: A Murine Model of Breast Cancer

Tocotrienol-rich fraction (TRF) from palm oil is reported to possess anti-cancer and immune-enhancing effects. In this study, TRF supplementation was used as an adjuvant to enhance the anti-cancer effects of dendritic cells (DC)-based cancer vaccine in a syngeneic mouse model of breast cancer. Female BALB/c mice were inoculated with 4T1 cells in mammary pad to induce tumor. When the tumor was palpable, the mice in the experimental groups were injected subcutaneously with DC-pulsed with tumor lysate (TL) from 4T1 cells (DC+TL) once a week for three weeks and fed daily with 1 mg TRF or vehicle. Control mice received unpulsed DC and were fed with vehicle. The combined therapy of using DC+TL injections and TRF supplementation (DC+TL+TRF) inhibited (p<0.05) tumor growth and metastasis. Splenocytes from the DC+TL+TRF group cultured with mitomycin-C (MMC)-treated 4T1 cells produced higher (p<0.05) levels of IFN-γ and IL-12. The cytotoxic T-lymphocyte (CTL) assay also showed enhanced tumor-specific killing (p<0.05) by CD8+ T-lymphocytes isolated from mice in the DC+TL+TRF group. This study shows that TRF has the potential to be used as an adjuvant to enhance effectiveness of DC-based vaccines.