Miracle-dz/UniFAR-FTUs huggingface dataset:
A Study of Digital Game Addiction from Aggression, Loneliness and Depression Perspectives

Previous studies showed the effects of psychological variables such as depression and loneliness on game addiction. Likewise, the effect of aggression on game addiction has also been reported. However, little research has empirically proved the role of aggression between the psychological variables and game addiction. In addition, in the context of game addiction, few studies have investigated their relationships in an integrated model using sub-factors of each construct. With survey data of 789 subjects, focused on the psychosocial variables (e.g., aggression, depression, and loneliness), the current study analyzed a path model to examine 1) the effects of loneliness and depression on aggression, 2) the psychosocial variables' effect on game addiction, and 3) mediation role of aggression between psychological variables (e.g., depression and loneliness) and game addiction. Results showed the important roles of aggression in the model. Aggression was significantly affected by both loneliness and depression, and in turn, aggression was the strongest determinant on game addiction among the three variables. Notably, aggression played a mediation role between depression and game addiction. Results and implications were discussed.
Roots and development of capabilities in economic science: A bibliometric analysis

To achieve a sustainable competitive advantage a firm needs to pay close attention to its resources and capabilities. At present identifying and assessing capabilities is considered as one of the main challenges due to different constructs, understanding and perspectives about the term `Capability' itself and the role it plays in strategic management. The objectives of this research is to use bibliometric analysis to profile and structure the body of knowledge of the research field `Capabilities in Economic Science'. Co-word analysis is used to examine the relationships between different concepts of capabilities and their related sub-fields. The article shows that the research area of `Dynamic Capabilities' is not only highly relevant to develop an innovation strategy, but also considered a disputed research domain. The result of this research illustrates and classifies the current body of knowledge to identify gaps for future research and collaboration.
Smart Microgrids: Optimal Joint Scheduling for Electric Vehicles and Home Appliances

The integration of renewable energy sources and electrical vehicles (EVs) into microgrids is becoming a popular green approach. To reduce greenhouse gas emissions, several incentives are given to use renewable energy sources and EVs. By using EVs as electricity storage and renewable energy sources as distributed generators (DGs), microgrids become more reliable, stable, and cost-effective. In this paper, we propose an optimal centralized scheduling method to jointly control the electricity consumption of home appliances and plug-in EVs as well as to discharge the latter ones when they have excess energy, thereby increasing the reliability and stability of microgrids and giving lower electricity prices to customers. We mathematically formulate the scheduling method as a mixed integer linear programming (MILP) problem and solve it to optimality. We compare the optimal solution to that obtained from a scheduling framework, where EVs do not have discharge capabilities, decentralized charge control using game theory and to a solution obtained from a naive scheduling framework.
No Single Irreplaceable Acidic Residues in the Escherichia coli Secondary Multidrug Transporter MdfA

ABSTRACT The largest family of solute transporters (major facilitator superfamily [MFS]) includes proton-motive-force-driven secondary transporters. Several characterized MFS transporters utilize essential acidic residues that play a critical role in the energy-coupling mechanism during transport. Surprisingly, we show here that no single acidic residue plays an irreplaceable role in the Escherichia coli secondary multidrug transporter MdfA.
Focal Adhesion Kinase Regulates Neuronal Growth, Synaptic Plasticity and Hippocampus-Dependent Spatial Learning and Memory

The focal adhesion kinase (FAK) is a non-receptor tyrosine kinase abundantly expressed in the mammalian brain and highly enriched in neuronal growth cones. Inhibitory and facilitatory activities of FAK on neuronal growth have been reported and its role in neuritic outgrowth remains controversial. Unlike other tyrosine kinases, such as the neurotrophin receptors regulating neuronal growth and plasticity, the relevance of FAK for learning and memory in vivo has not been clearly defined yet. A comprehensive study aimed at determining the role of FAK in neuronal growth, neurotransmitter release and synaptic plasticity in hippocampal neurons and in hippocampus-dependent learning and memory was therefore undertaken using the mouse model. Gain- and loss-of-function experiments indicated that FAK is a critical regulator of hippocampal cell morphology. FAK mediated neurotrophin-induced neuritic outgrowth and FAK inhibition affected both miniature excitatory postsynaptic potentials and activity-dependent hippocampal long-term potentiation prompting us to explore the possible role of FAK in spatial learning and memory in vivo. Our data indicate that FAK has a growth-promoting effect, is importantly involved in the regulation of the synaptic function and mediates in vivo hippocampus-dependent spatial learning and memory.
Immunologic Characterization of Posthepatitis Cirrhosis Caused by HBV and HCV Infection

No specific treatment can reverse the liver injury in cirrhosis. This study aims to characterize immune status and correlations between cirrhosis induced by HBV and HCV. Phenotypes of peripheral blood lymphocyte subsets (T, NK, regulatory T cells) and Th cytokine secretion were analyzed using flow cytometry in 42 HBV-cirrhotic and 40 HCV-cirrhotic patients. Cirrhotic patients had a lower proportion of CD3+CD8+T cells and NK cells, while the proportion of CD3+CD4+T cells and Treg cells were higher than those of healthy controls. The levels of Th2 cytokine (IL-6) in cirrhotic patients were increased, while only the Th1 cytokine (IFN-γ) increased in HBV-cirrhotic patients. These findings show that there is no difference between the cirrhotic groups except in the IFN-γ level. In cirrhosis, defects in innate, adaptive immune cells are likely regardless of which virus is involved. A cytokine imbalance may play a role in the development of posthepatitic cirrhosis.
Fibromyalgia: the role of sleep in affect and in negative event reactivity and recovery.

OBJECTIVE Fibromyalgia (FM) syndrome is a chronic pain condition characterized by diffuse muscle pain, increased negative mood, and sleep disturbance. Until recently, sleep disturbance in persons with FM has been modeled as the result of the disease process or its associated pain. The current study examined sleep disturbance (i.e., sleep duration and sleep quality) as a predictor of daily affect, stress reactivity, and stress recovery. DESIGN AND MEASURES A hybrid of daily diary and ecological momentary assessment methodology was used to evaluate the psychosocial functioning of 89 women with FM. Participants recorded numeric ratings of pain, fatigue, and positive and negative affect 3 times throughout the day for 30 consecutive days. At the end of each day, participants completed daily diary records of positive and negative life events. In addition, participants reported on their sleep duration and sleep quality each morning. RESULTS After accounting for the effects of positive events, negative events, and pain on daily affect scores, it was found that sleep duration and quality were prospectively related to affect and fatigue. Furthermore, the effects of inadequate sleep on negative affect were cumulative. In addition, an inadequate amount of sleep prevented affective recovery from days with a high number of negative events. CONCLUSIONS These results lend support to the hypothesis that sleep is a component of allostatic load and has an upstream role in daily functioning.
Effects of degradation of intensity, time, or frequency content on speech intelligibility for normal-hearing and hearing-impaired listeners.

Many hearing-impaired listeners suffer from distorted auditory processing capabilities. This study examines which aspects of auditory coding (i.e., intensity, time, or frequency) are distorted and how this affects speech perception. The distortion-sensitivity model is used: The effect of distorted auditory coding of a speech signal is simulated by an artificial distortion, and the sensitivity of speech intelligibility to this artificial distortion is compared for normal-hearing and hearing-impaired listeners. Stimuli (speech plus noise) are wavelet coded using a complex sinusoidal carrier with a Gaussian envelope (1/4 octave bandwidth). Intensity information is distorted by multiplying the modulus of each wavelet coefficient by a random factor. Temporal and spectral information are distorted by randomly shifting the wavelet positions along the temporal or spectral axis, respectively. Measured were (1) detection thresholds for each type of distortion, and (2) speech-reception thresholds for various degrees of distortion. For spectral distortion, hearing-impaired listeners showed increased detection thresholds and were also less sensitive to the distortion with respect to speech perception. For intensity and temporal distortion, this was not observed. Results indicate that a distorted coding of spectral information may be an important factor underlying reduced speech intelligibility for the hearing impaired.
Effects of post-deposition annealing time in oxygen ambient on Y2O3 film deposited on silicon substrate

Abstract In this work, systematic investigation was performed to study the effects of post-deposition annealing time (15, 30 and 45 minutes) at 1000°C in oxygen ambient on electrical characteristics of Y2O3 gate deposited on Si substrate using radio frequency magnetron sputtering. Capacitance–voltage characteristics of the investigated samples deduced the presence of positive-charged traps through the attainment of negative flatband voltage shift. Sample post-deposition annealing at 30 minutes demonstrated the lowest leakage current density and the highest breakdown voltage. This was owing to the acquisition of the lowest effective oxide charge, slow trap density, interface-trap density and total interface-trap density. It was determined that the leakage current of samples post-deposition annealing at 15 and 30 minutes is governed by Ohm's law, Mott–Gurney law and trap-filled-limit conduction. Only Ohm's law and trap-filled-limit conduction are dominating the leakage current of samples post-deposition annealing at 45 minutes.
Fabrication and Mechanical Properties of Completely Biodegradable Hemp Fiber Reinforced Polylactic Acid Composites

Biodegradable composite materials can be produced by the combination of biodegradable polymers and natural fibers. In this study, a new biodegradable composite of hemp fiber reinforced polylactic acid (PLA) was fabricated using the hot press method. Mechanical properties of composites with different fiber volume fractions were tested. The optimum fiber content was determined according to the test results. Effects of alkali treatment on the fiber surface morphology and the mechanical properties of the composites were investigated. Test results show that the composite with 40% volume fraction of alkali treated fiber has the best mechanical properties. The tensile strength, elastic modulus, and flexural strength of the composite with 40% treated fiber are 54.6 MPa, 8.5 Gpa, and 112.7 MPa respectively, which are much higher than those of PLA alone. The composites have lower densities, which were measured to be from 1.19 g/cm3 to 1.25 g/cm3. Specific strengths were also calculated. Surface morphologies of fiber and fracture surfaces of the composites were observed using the SEM method.
Pharmacotherapy in patients with stable coronary artery disease treated on an outpatient basis in Poland. Results of the multicentre RECENT study.

BACKGROUND Comprehension of therapeutic methods in patients with stable coronary artery disease (CAD) is mandatory for the introduction of successful prevention. AIM To gather information regarding individuals with stable coronary artery disease treated by specialists and general practitioners on an outpatient basis. METHODS A representative group of 215 general practitioners and 67 specialists participated in this study. The analysis contains data concerning pharmacotherapy in a group of 2,593 patients with stable CAD (mean age - 65.0+/-9.8 years, women - 44.6%). RESULTS The patients received the following treatment: acetylsalicylic acid - 75.3%, other antiplatelet drugs - 6.6% (antiplatelet drugs altogether - 81.9%), beta-blockers - 81.1%, ACE-I - 78.8%, statins - 71.9%, fibrates - 4.7%, long-acting nitrates - 53.0%, short--acting nitrates - 33.1%, molsidomine - 18.2%, calcium channel blockers - 23.8%, metabolic drugs (trimetazidine) - 13.4%, diuretics - 43.5%, and angiotensin receptor antagonists - 1.7% of patients. Drugs classified as non-cardiological were received by 36.2% of patients. The optimal pharmacotherapy including four medications, one from each therapeutic class used in order to improve the prognosis of the patient (an antiplatelet drug, a beta-blocker, an ACE-I, statin), was received by a total of 45.8% of the participants, three medications by 31.7%, two medications by 15.8%, and one medication by 5.5%; 1.2% of the participants did not receive any medication from the four groups of drugs improving prognosis. What is worth noting, however, is the use of relatively small doses of ACE-I and beta-blockers. 69.9% of patients also received at least one symptomatic drug (a long-acting nitrate, a calcium channel blocker, a metabolic drug, molsidomine), including 39.7% - 1 drug, 22.7% - 2 drugs, 6.7% - 3 drugs, and 0.8% - 4 drugs from the classes mentioned above. CONCLUSIONS The results of the RECENT study indicate that great progress has been made in the pharmacotherapy of CAD in Poland within the last few years. Currently, the majority of patients receive drugs that improve prognosis. The awareness of the benefits of the use of combined treatment with all the drug groups and their appropriate doses should be higher. The significant percentage of patients with persisting symptoms of angina pectoris indicates the necessity to improve the efficacy of intervention also in this respect.
Intergalactic C iv absorption at redshifts 5.4 to 6

We report the discovery of a strong C IV λλ1548,1550 absorption system at zabs = 5.7238 in the near-infrared spectrum (J -band) of the zem = 6.28 QSO SDSS J1030+0524. These observations, obtained with the Infrared Spectrometer And Array Camera (ISAAC) on the European Southern Observatory Very Large Telescope (ESO VLT), demonstrate that, with modern instrumentation, QSO absorption line spectroscopy can be successfully extended to near-infrared wavelengths to probe the intergalactic medium near the end of the reionization epoch. Although the statistics of this pilot study are limit ed, the mass density of triply ionized carbon implied by our data is comparable to the values of C IV reported at lower redshifts. Neither the column density distribution of C IV absorbers nor its integral show significant redshift evolution over a period of time which stretches fro m 1 to 4.5 Gyr after the big bang, suggesting that a large fraction of intergalactic metals ma y already have been in place at redshifts above 6. Alternatively, the strong C IV system we have detected may be associated with outflowing, highly-ionized, gas from a foreground mass ive galaxy; deep imaging and spectroscopy of galaxies near the QSO sightline should be able to distinguish between these two possibilities.
On the Performance Benefits of Multihoming Route Control

Multihoming is increasingly being employed by large enterprises and data centers to extract good performance and reliability from their ISP connections. Multihomed end networks today can employ a variety of route control products to optimize their Internet access performance and reliability. However, little is known about the tangible benefits that such products can offer, the mechanisms they employ and their trade-offs. This paper makes two important contributions. First, we present a study of the potential improvements in Internet round-trip times (RTTs) and transfer speeds from employing multihoming route control. Our analysis shows that multihoming to three or more ISPs and cleverly scheduling traffic across the ISPs can improve Internet RTTs and throughputs by up to 25% and 20%, respectively. However, a careful selection of ISPs is important to realize the performance improvements. Second, focusing on large enterprises, we propose and evaluate a wide-range of route control mechanisms and evaluate their design trade-offs. We implement the proposed schemes on a Linux-based Web proxy and perform a trace-based evaluation of their performance. We show that both passive and active measurement-based techniques are equally effective and could improve the Web response times of enterprise networks by up to 25% on average, compared to using a single ISP. We also outline several "best common practices" for the design of route control products.
Recent trends in hepatitis B virus infection in the general Korean population

Background/Aims Hepatitis B virus (HBV) is the major cause of chronic liver disease in Korea, but viral prevalence has decreased because of hepatitis B vaccination programs. In this study, we investigated longitudinal changes in HBV in fection in the general Korean population. Methods HBV surface antigen (hepatitis B surface antigen, HBsAg) seropositivity was assessed from the Korea National Health and Nutrition Examination Survey (I to V). In total, 50,140 subjects were tested for serum HBsAg positivity over a period of 12 years (1998 to 2010). Results The prevalence of HBsAg seropositivity decreased over the study period. The rates of HBsAg carriers were 4.61% in 1998, 4.60% in 2001, 3.69% in 2005, 3.01% in 2008, and 2.98% in 2010 (p < 0.0001). The reduction in HBV infection rates was more prominent in younger age groups. Among teenagers (10 to 19 years), the percentage of HBsAg carriers decreased from 2.2% in 1998 to 0.12% in 2010 (p < 0.0001). Among those aged 10 to 39 years, the percentage of HBV infection decreased from 4.72% in 1998 to 2.29% in 2010 (p < 0.0001). However, no decreasing trend in HBsAg positivity was observed among those aged 50 or older (p > 0.05). Neither gender nor socioeconomic status were associated with the decreased prevalence of HBsAg carriers. Conclusions HBV infection has decreased in the Korean population since the advent of vaccination programs. However, the decrease is limited to the younger population, and viral persistence remains in the middle-aged and older population.
Reporting of Adverse Events in Published and Unpublished Studies of Health Care Interventions: A Systematic Review

Background We performed a systematic review to assess whether we can quantify the underreporting of adverse events (AEs) in the published medical literature documenting the results of clinical trials as compared with other nonpublished sources, and whether we can measure the impact this underreporting has on systematic reviews of adverse events. Methods and Findings Studies were identified from 15 databases (including MEDLINE and Embase) and by handsearching, reference checking, internet searches, and contacting experts. The last database searches were conducted in July 2016. There were 28 methodological evaluations that met the inclusion criteria. Of these, 9 studies compared the proportion of trials reporting adverse events by publication status. The median percentage of published documents with adverse events information was 46% compared to 95% in the corresponding unpublished documents. There was a similar pattern with unmatched studies, for which 43% of published studies contained adverse events information compared to 83% of unpublished studies. A total of 11 studies compared the numbers of adverse events in matched published and unpublished documents. The percentage of adverse events that would have been missed had each analysis relied only on the published versions varied between 43% and 100%, with a median of 64%. Within these 11 studies, 24 comparisons of named adverse events such as death, suicide, or respiratory adverse events were undertaken. In 18 of the 24 comparisons, the number of named adverse events was higher in unpublished than published documents. Additionally, 2 other studies demonstrated that there are substantially more types of adverse events reported in matched unpublished than published documents. There were 20 meta-analyses that reported the odds ratios (ORs) and/or risk ratios (RRs) for adverse events with and without unpublished data. Inclusion of unpublished data increased the precision of the pooled estimates (narrower 95% confidence intervals) in 15 of the 20 pooled analyses, but did not markedly change the direction or statistical significance of the risk in most cases. The main limitations of this review are that the included case examples represent only a small number amongst thousands of meta-analyses of harms and that the included studies may suffer from publication bias, whereby substantial differences between published and unpublished data are more likely to be published. Conclusions There is strong evidence that much of the information on adverse events remains unpublished and that the number and range of adverse events is higher in unpublished than in published versions of the same study. The inclusion of unpublished data can also reduce the imprecision of pooled effect estimates during meta-analysis of adverse events.
Antibodies to human herpes virus‐6 and clinical course in patients with Hodgkin's disease

Serial serum samples from 37 patients with Hodgkin's disease (HD) and 39 healthy controls were studied for antibodies to human herpes virus‐6 (HHV‐6) using ELISA and indirect immunofluorescent antibody (IFA) tests and to the Epstein‐Barr virus (EBV) using a radio‐complement fixation assay. Antibodies to HHV‐6 in the pre‐treatment sera from the HD patients were not significantly different from those of controls, but significant changes in titers related to clinical course were noted among the HD patients. HHV‐6 IFA titers increased significantly in the course of follow‐up in patients who relapsed and decreased significantly over time in patients who did not. These serologic studies support tissue‐based investigations indicating that EBV plays a greater etiologic role in HD than HHV‐6, although HHV‐6 serology may be of prognostic value or may assist in identifying individuals with immunologic abnormalities. The identification of diverse HHV‐6 antibody patterns using different assays may reflect the presence of a number of antibodies with varying implications, similar to those identified for EBV.