Miracle-dz/UniFAR-FTUs huggingface dataset:
Enhanced Vasodilator Activity of Nitrite in Hypertension: Critical Role for Erythrocytic Xanthine Oxidoreductase and Translational Potential

Elevation of circulating nitrite (NO2 −) levels causes vasodilatation and lowers blood pressure in healthy volunteers. Whether these effects and the underpinning mechanisms persist in hypertension is unknown. Therefore, we investigated the consequences of systemic nitrite elevation in spontaneously hypertensive rats and conducted proof-of-principle studies in patients. Nitrite caused dose-dependent blood pressure–lowering that was profoundly enhanced in spontaneously hypertensive rats versus normotensive Wistar Kyoto controls. This effect was virtually abolished by the xanthine oxidoreductase (XOR) inhibitor, allopurinol, and associated with hypertension-specific XOR-dependent nitrite reductase activity localized to the erythrocyte but not the blood vessel wall. To determine whether these pathways translate to human hypertension, we investigated the effects of elevation of circulating nitrite levels in 15 drug naïve grade 1 hypertensives. To elevate nitrite, we used a dose of dietary nitrate (≈3.5 mmol) that elevated nitrite levels ≈1.5-fold (P<0.01); a rise shown previously to exert no significant blood pressure–lowering effects in normotensives. This dose caused substantial reductions in systolic (≈12 mm Hg) and diastolic blood pressures (P<0.001) and pulse wave velocity (P<0.05); effects associated with elevations in erythrocytic XOR expression and XOR-dependent nitrite reductase activity. Our observations demonstrate the improved efficacy of inorganic nitrate and nitrite in hypertension as a consequence of increased erythrocytic XOR nitrite reductase activity and support the concept of dietary nitrate supplementation as an effective, but simple and inexpensive, antihypertensive strategy.
Network monitoring and management approach for expressive-based SLA of grid computing applications

In this paper, we present a performance analysis of a dynamic bandwidth monitoring method with flow control functionality, for intensive data-passing grid applications over wide area networks. The proposed method called flatness based trajectory tracking, adapts the grid users output rates to match expressive data-transfer SLA used to describe theirs guarantees parameters. The control considers time delay transfer by using delay predictor and provides value-added services for grid applications over Internet. This reactive monitoring uses purely control theoretic approaches which stabilize the network and avoid undesirable oscillations for the transmission of such critical flows. Moreover, discrete-time simulation under GridSim simulator illustrates its feasibility and efficiency to provide guarantees for critical grid traffics with timely execution requirements.
Binarization of Synchronous Context-Free Grammars

Abstract Systems based on synchronous grammars and tree transducers promise to improve the quality of statistical machine translation output, but are often very computationally intensive. The complexity is exponential in the size of individual grammar rules due to arbitrary re-orderings between the two languages. We develop a theory of binarization for synchronous context-free grammars and present a linear-time algorithm for binarizing synchronous rules when possible. In our large-scale experiments, we found that almost all rules are binarizable and the resulting binarized rule set significantly improves the speed and accuracy of a state-of-the-art syntax-based machine translation system. We also discuss the more general, and computationally more difficult, problem of finding good parsing strategies for non-binarizable rules, and present an approximate polynomial-time algorithm for this problem.
Deploying Approaches for Pattern Refinement in Text Mining

Text mining is the technique that helps users find useful information from a large amount of digital text documents on the Web or databases. Instead of the keyword-based approach which is typically used in this field, the pattern-based model containing frequent sequential patterns is employed to perform the same concept of tasks. However, how to effectively use these discovered patterns is still a big challenge. In this study, we propose two approaches based on the use of pattern deploying strategies. The performance of the pattern deploying algorithms for text mining is investigated on the Reuters dataset RCVI and the results show that the effectiveness is improved by using our proposed pattern refinement approaches.
Plasma oxidative stress is induced by single‐sprint anaerobic exercise in young cigarette smokers

Cigarette smoking increases oxidative stress, which is a risk factor for several diseases. Smoking has also been reported to enhance plasma oxidative stress during strenuous exercise. However, no prior study has examined the changes in plasma oxidative stress after single‐sprint anaerobic exercise in cigarette smokers. The purpose of this study was to investigate these changes in young cigarette smokers by measuring reactive oxygen species generation and total antioxidant content. Participants were 15 male smokers (mean age: 25·9 ± 2·9 years) and 18 male non‐smokers (mean age: 24·2 ± 4·3 years). Hydroperoxide concentration and biological antioxidant potential (BAP) in plasma were measured at baseline and after the Wingate anaerobic test. A significant interaction between group and time was observed for plasma hydroperoxide concentration (P = 0·037). Plasma hydroperoxide concentration was significantly increased after exercise in both smokers and non‐smokers (P = 0·001 and <0·001, respectively). However, no significant interaction was observed between groups by time on plasma BAP (P = 0·574), and a main effect of time was observed (P<0·001). Plasma BAP was significantly increased after exercise in both groups (both, P<0·001). These findings indicate that plasma oxidative stress is higher in cigarette smokers than in non‐smokers after single‐sprint anaerobic exercise, which may increase the risk of oxidative damage.
Diet and kwashiorkor: a prospective study from rural DR Congo

The etiology of kwashiorkor remains enigmatic and longitudinal studies examining potential causes of kwashiorkor are scarce. Using historical, longitudinal study data from the rural area of Bwamanda, Democratic Republic of Congo, we investigated the potential causal association between diet and the development of kwashiorkor in 5 657 preschool children followed 3-monthly during 15 months. We compared dietary risk factors for kwashiorkor with those of marasmus. Kwashiorkor was diagnosed as pitting oedema of the ankles; marasmus as abnormal visibility of skeletal structures and palpable wasting of the gluteus muscle. A 24-h recall was administered 3-monthly to record the consumption of the 41 locally most frequent food items. We specified Hanley–Miettinen smooth-in-time risk models containing potential causal factors, including food items, special meals prepared for the child, breastfeeding, disease status, nutritional status, birth rank, age, season and number of meals. Bayesian Information Criteria identified the most plausible causal model of why some children developed kwashiorkor. In a descriptive analysis of the diet at the last dietary assessment prior to development of kwashiorkor, the diet of children who developed kwashiorkor was characterized by low consumption of sweet potatoes, papaya and “other vegetables” [0.0% , 2.3% (95% CI [0.4, 12.1]) and 2.3% (95% CI [0.4, 12.1])] in comparison with children who did not develop kwashiorkor [6.8% (95% CI [6.4, 7.2]), 15.5% (95% CI [15, 16.1]) and 15.1% (95% CI [14.6, 15.7])] or children who developed marasmus [4.5% (95% CI [2.6, 7.5]) 11.8% (95% CI [8.5, 16.0]) and 17.6% (95% CI [13.7, 22.5])]. Sweet potatoes and papayas have high β-carotene content and so may some of “the other vegetables”. We found that a risk model containing an age function, length/height-for age Z-score, consumption of sweet potatoes, papaya or other vegetables, duration of this consumption and its interaction term, was the most plausible model. Among children aged 10–42 months, the risk of developing kwashiorkor increased with longer non-consumption of these foods. The analysis was repeated with only children who developed marasmus as the reference series, yielding similar results. Our study supports that β-carotene may play an important role in the protection against kwashiorkor development.
Directed proxy signature with fast revocation proven secure in the standard model

As a kind of special proxy signature, directed proxy signature can be used to sign messages, such that only the designated verifier can easily verify the validity of the signature while others cannot. At the same time, if necessary, the proxy signer or designated verifier can prove the validity of the signature to any third party. However, the revocation of delegated rights has never been considered in the existing directed proxy signature schemes. In fact, in these directed proxy signature schemes, even if the period of delegation has expired, the proxy signer still can generate the valid proxy signature, and the original signer can do nothing to prevent it. Therefore, the authors give a solution to the delegation revocation problem and propose a directed proxy signature scheme with fast revocation in this study. The security and the invisibility of the authors’ scheme are proven based on the gap Diffie–Hellman assumption and under the decisional Diffie–Hellman problem in the standard model, respectively.
Variations in cone populations for red–green color vision examined by analysis of mRNA

IN the central human retina, there are estimated to be nearly two L cone photoreceptors for each M cone. The extent to which this value varies across individuals is unclear and little is known about how the M:L cone ratio might change with retinal location. To address these questions, the ratio of M:L cone pigment mRNA was examined at different locations. For patches of central retina, the average M:L ratio was about 2:3 which decreased to about 1:3 for patches 40°eccentric. There were also large individual differences among the 23 eyes examined. The extremes differed in central M:L mRNA ratio by a factor of > 3. The measured differences in mRNA ratio are proposed to reflect differences in photo-receptor ratio. Such variations provide unique opportunities for understanding how the neural circuitry for color vision is affected by changes in cone ratio.
Multiple trajectory search for Large Scale Global Optimization

In this paper, the multiple trajectory search (MTS) is presented for large scale global optimization. The MTS uses multiple agents to search the solution space concurrently. Each agent does an iterated local search using one of three candidate local search methods. By choosing a local search method that best fits the landscape of a solutionpsilas neighborhood, an agent may find its way to a local optimum or the global optimum. We applied the MTS to the seven benchmark problems designed for the CEC 2008 Special Session and Competition on large scale global optimization.
LuxS and quorum-sensing in Campylobacter

Several intercellular bacterial communication mechanisms have been identified in a broad range of bacterial species. These systems, collectively termed quorum-sensing systems, have been demonstrated to play significant roles in a variety of bacterial processes including motility, biofilm formation, expression of virulence genes, and animal colonization. Campylobacter jejuni is known to possess a LuxS/ autoinducer-2 (AI-2) mediated system that have been partially characterized over the last decade. AI-2 is formed as a byproduct of the activated methyl recycling pathway, specifically by the LuxS enzyme. Previous work in our laboratory and that of others has demonstrated that this gene is involved in a variety of physiologic pathways of C. jejuni including motility, autoagglutination, cytolethal distending toxin (CDT) expression, flagellar expression, oxidative stress, and animal colonization. This review article will summarize the current research associated with LuxS in C. jejuni and will provide insights into the role of this system in the metabolism and intercellular communication of this organism. Additionally, the evidence for other quorum-sensing pathways in Campylobacter will be discussed.
Systemic dissemination of Clostridium difficile toxins A and B is associated with severe, fatal disease in animal models.

BACKGROUND Clostridium difficile infection (CDI) can cause a wide range of disease, from mild diarrhea to fulminant systemic disease. The incidence of systemic CDI with fatal consequence has increased rapidly in recent years. METHODS Using an ultrasensitive cytotoxicity assay, we measured C. difficile toxin A (TcdA) and C. difficile toxin B (TcdB) in sera and body fluids of piglets and mice exposed to C. difficile to investigate the relationship between the presence of toxins in body fluids and systemic manifestations of CDI. RESULTS We found that both TcdA and TcdB disseminate systemically, with toxins present in the sera and body fluids of infected animals, and toxemia is significantly correlated with the development of systemic CDI. The systemic administration of neutralizing antibodies against both toxins blocked the development of systemic disease in mice. We measured cytokine concentrations in the sera of mice and piglets with systemic and nonsystemic CDI and found that proinflammatory mediators were considerably elevated in animals with systemic CDI. CONCLUSION Our study demonstrates the existence of a strong correlation between toxemia and the occurrence of systemic disease, supporting the hypothesis that systemic CDI is most likely due to the toxicity of TcdA and TcdB and the induction of proinflammatory cytokines by the toxins.
A Corpus-based Investigation of Definite Description Use

We present the results of a study of the use of definite descriptions in written texts aimed at assessing the feasibility of annotating corpora with information about definite description interpretation. We ran two experiments, in which subjects were asked to classify the uses of definite descriptions in a corpus of 33 newspaper articles, containing a total of 1,412 definite descriptions. We measured the agreement among annotators about the classes assigned to definite descriptions, as well as the agreement about the antecedent assigned to those definites that the annotators classified as being related to an antecedent in the text. The most interesting result of this study from a corpus annotation perspective was the rather low agreement (K = 0.63) that we obtained using versions of Hawkins's and Prince's classification schemes; better results (K = 0.76) were obtained using the simplified scheme proposed by Fraurud that includes only two classes, first-mention and subsequent-mention. The agreement about antecedents was also not complete. These findings raise questions concerning the starategy of evaluating systems for definite description interpretation by comparing their results with a standardized annotation. From a linguistic point of view, the most interesting observations were the great number of discourse-new definites in our corpus (in one of our experiments, about 50% of the definites in the collection were classified as discourse-new, 30% as anaphoric, and 18% as associative/bridging) and the presence of definites that did not seem to require a complete disambiguation.
Enhanced Fidelity of 3TC-Selected Mutant HIV-1 Reverse Transcriptase

Monotherapy with (−)2′,3′-dideoxy-3′-thiacytidine (3TC) leads to the appearance of a drug-resistant variant of human immunodeficiency virus-type 1 (HIV-1) with the methionine-184 → valine (M184V) substitution in the reverse transcriptase (RT). Despite resulting drug resistance, treatment for more than 48 weeks is associated with a lower plasma viral burden than that at baseline. Studies to investigate this apparent contradiction revealed the following. (i) Titers of HIV-neutralizing antibodies remained stable in 3TC-treated individuals in contrast to rapid declines in those treated with azidothymidine (AZT). (ii) Unlike wild-type HIV, growth of M184V HIV in cell culture in the presence of d4T, AZT, Nevirapine, Delavirdine, or Saquinavir did not select for variants displaying drug resistance. (iii) There was an increase in fidelity of nucleotide insertion by the M184V mutant compared with wild-type enzyme.
Evaluating Management Factor Contributions to Reduce Corn Yield Gaps

Published in Agron. J. 107:495–505 (2015) doi:10.2134/agronj14.0355 Available freely online through the author-supported open access option. Copyright © 2015 by the American Society of Agronomy, 5585 Guilford Road, Madison, WI 53711. All rights reserved. No part of this periodical may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or any information storage and retrieval system, without permission in writing from the publisher. ABSTRACT
Caching and Transport Protocols Performance in Content-Centric Networks

Today Internet is significantly shifting towards a network model where contents play a central role, while the underlying architecture remains as it was initially designed decades ago. This evident mismatch between design and usage has posed many problems that the old architecture fundamentally cannot solve. Considering this situation, many pioneering ideas have been proposed; Content Centric Networking (CCN) is a promising one among them. This thesis elaborates the influences of CCN caching on transport protocols performance. Results of practical tests are shown and compared with a theoretical model, helping us to think further the development of this innovative technology.
Functional genome-wide siRNA screen identifies KIAA0586 as mutated in Joubert syndrome

Defective primary ciliogenesis or cilium stability forms the basis of human ciliopathies, including Joubert syndrome (JS), with defective cerebellar vermis development. We performed a high-content genome-wide small interfering RNA (siRNA) screen to identify genes regulating ciliogenesis as candidates for JS. We analyzed results with a supervised-learning approach, using SYSCILIA gold standard, Cildb3.0, a centriole siRNA screen and the GTex project, identifying 591 likely candidates. Intersection of this data with whole exome results from 145 individuals with unexplained JS identified six families with predominantly compound heterozygous mutations in KIAA0586. A c.428del base deletion in 0.1% of the general population was found in trans with a second mutation in an additional set of 9 of 163 unexplained JS patients. KIAA0586 is an orthologue of chick Talpid3, required for ciliogenesis and Sonic hedgehog signaling. Our results uncover a relatively high frequency cause for JS and contribute a list of candidates for future gene discoveries in ciliopathies. DOI: http://dx.doi. org/10.7554/eLife.06602. 001
Wavelength converter sharing in asynchronous optical packet/burst switching: An exact blocking analysis for markovian arrivals

In this paper, we study the blocking probabilities in a wavelength division multiplexing-based asynchronous bufferless optical packet/burst switch equipped with a bank of tuneable wavelength converters dedicated to each output fiber line. Wavelength converter sharing, also referred to as partial wavelength conversion, corresponds to the case of a number of converters shared amongst a larger number of wavelength channels. In this study, we present a probabilistic framework for exactly calculating the packet blocking probabilities for optical packet/burst switching systems utilizing wavelength converter sharing. In our model, packet arrivals at the optical switch are first assumed to be Poisson and later generalized to the more general Markovian arrival process to cope with very general traffic patterns whereas packet lengths are assumed to be exponentially distributed. As opposed to the existing literature based on approximations and/or simulations, we formulate the problem as one of finding the steady-state solution of a continuous-time Markov chain with a block tridiagonal infinitesimal generator. To find such solutions, we propose a numerically efficient and stable algorithm based on block tridiagonal LU factorizations. We show that exact blocking probabilities can be efficiently calculated even for very large systems and rare blocking probabilities, e.g., systems with 256 wavelengths per fiber and blocking probabilities in the order of 10-40. Relying on the stability and speed of the proposed algorithm, we also provide a means of provisioning wavelength channels and converters in optical packet/burst switching systems.
Behavioral Change and Its Neural Correlates in Visual Agnosia After Expertise Training

Agnosia, the impairment in object and face recognition despite intact vision and intelligence, is one of the most intriguing and debilitating neuropsychological deficits. The goal of this study was to determine whether S.M. , an individual with longstanding visual agnosia and concomitant prosopagnosia, can be retrained to perform visual object recognition and, if so, what neural substrates mediate this reacquisition. Additionally, of interest is the extent to which training on one type of visual stimulus generalizes to other visual stimuli, as this informs our understanding of the organization of ventral visual cortex. Greebles were chosen as the stimuli for retraining given that, in neurologically normal individuals, these stimuli can engage the fusiform face area. Posttraining, S.M. showed significant improvement in recognizing Greebles, although he did not attain normal levels of performance. He was also able to recognize untrained Greebles and showed improvement in recognizing common objects. Surprisingly, his performance on face recognition, albeit poor initially, was even more impaired following training. A comparison of preand postintervention functional neuroimaging data mirrored the behavioral findings: Face-selective voxels in the fusiform gyrus prior to training were no longer so and were, in fact, more Greeble-selective. The findings indicate potential for experience-dependent dynamic reorganization in agnosia with the possibility that residual neural tissue, with limited capacity, will compete for representations.
A Survey on Mac Protocols for Wireless Sensor Networks

— Wireless Sensor Network (WSN) is an infra-structure-less wireless network of nodes that can sense the environment or physical conditions and relay the data to a sink or a gateway possibly through multiple hops. The primary task of Medium Access Control (MAC) protocols in such a network is to synchronize the task of data communication between the nodes with energy efficiency being the prime consideration due to power constraints in sensor nodes. So the most significant performance specifications for MAC protocols in WSN are throughput, efficiency, stability, fairness, low access delay, low transmission delay and low overhead. In this paper we have surveyed significant classes of MAC protocols used in WSN and reviewed the merits and demerits of those protocols based on the aforementioned specifications.