Miracle-dz/UniFAR-FTUs huggingface dataset:
Antiretroviral therapy for HIV-1-infected children in Haiti.

BACKGROUND Data are limited about the effectiveness of pediatric antiretroviral therapy (ART) in low-income countries. METHODS We report the outcomes of consecutively treating 236 human immunodeficiency virus type 1 (HIV-1)-infected treatment-naive children with triple ART in Port-au-Prince, Haiti, between 1 May 2003 and 30 April 2006. RESULTS Kaplan-Meier survival analysis at follow-up demonstrated that 191 children (81%) remained in care, 21 (9%) were dead, and 24 (10%) were lost to follow-up. Independent baseline predictors of mortality were age <18 months, CD4(+) T cell percentage < or =5%, and weight-for-age Z score (WAZ) less than -3. Twelve months into ART, 56% of tested subjects had undetectable HIV-1 RNA loads. Median CD4(+) T cell percentages at 12 months increased by 15%, 11%, and 5% in children with baseline percentages of < or =5%, 6%-24%, and > or =25%, respectively (P<.01). The median WAZ at 12 months increased by 1.0, 0.6, and 0.2 in children with baseline WAZ less than -2, -2 to -1.1, and -1 or more, respectively (P<.01). CONCLUSION With continuous donor support, trained providers, and the availability of pediatric antiretroviral drug formulations, it proved feasible to deliver pediatric ART in Haiti. The effectiveness of this program should encourage efforts to make ART available for HIV-infected children in poor countries.
Percutaneous endoscopic, radiological and surgical gastrostomy tubes: a comparison study in head and neck cancer patients

A gastrostomy feeding tube has become the most acceptable method for long-term feeding support in patients with head and neck cancer. The aim of this study was to compare the complications of percutaneous endoscopically inserted gastrostomy (PEG) tubes, radiologically inserted gastrostomy (RIG) tubes and surgically inserted gastrostomy (open/laparoscopic) (SUR) tubes in head and neck cancer patients and also to compare the mortality rates of these patients. Seventy-eight head and neck cancer patients underwent gastrostomy tube insertion (40 PEG, 28 RIG and 10 SUR) during the period February 2002 to February 2005. There were no significant demographic differences between the three groups. Thirty-six patients (46 per cent) developed complications, 32 minor and four major. All three groups were similar in their rate of minor complications, with the dislodgement and blockage rate being lowest in the PEG group (p > 0.05). The mortality rate was 4 per cent within 30 days of gastrostomy tube insertion. There were no deaths in the PEG group, two deaths in the RIG group and one in the SUR group. The PEG tube was considered superior to the RIG and SUR gastrostomy tubes, had fewer complications and was safer. Thus, PEG tube insertion is our first choice for head and neck cancer patients.
Developmental Changes of BOLD Signal Correlations with Global Human EEG Power and Synchronization during Working Memory

In humans, theta band (5–7 Hz) power typically increases when performing cognitively demanding working memory (WM) tasks, and simultaneous EEG-fMRI recordings have revealed an inverse relationship between theta power and the BOLD (blood oxygen level dependent) signal in the default mode network during WM. However, synchronization also plays a fundamental role in cognitive processing, and the level of theta and higher frequency band synchronization is modulated during WM. Yet, little is known about the link between BOLD, EEG power, and EEG synchronization during WM, and how these measures develop with human brain maturation or relate to behavioral changes. We examined EEG-BOLD signal correlations from 18 young adults and 15 school-aged children for age-dependent effects during a load-modulated Sternberg WM task. Frontal load (in-)dependent EEG theta power was significantly enhanced in children compared to adults, while adults showed stronger fMRI load effects. Children demonstrated a stronger negative correlation between global theta power and the BOLD signal in the default mode network relative to adults. Therefore, we conclude that theta power mediates the suppression of a task-irrelevant network. We further conclude that children suppress this network even more than adults, probably from an increased level of task-preparedness to compensate for not fully mature cognitive functions, reflected in lower response accuracy and increased reaction time. In contrast to power, correlations between instantaneous theta global field synchronization and the BOLD signal were exclusively positive in both age groups but only significant in adults in the frontal-parietal and posterior cingulate cortices. Furthermore, theta synchronization was weaker in children and was –in contrast to EEG power– positively correlated with response accuracy in both age groups. In summary we conclude that theta EEG-BOLD signal correlations differ between spectral power and synchronization and that these opposite correlations with different distributions undergo similar and significant neuronal developments with brain maturation.
Reactive techniques for controlling software speculation

Aggressive software speculation holds significant potential, because it enables program transformations to reduce the program's critical path. Like any form of speculation, however, the key to software speculation is employing it only where it is likely to succeed. While mechanisms for controlling hardware speculation (e.g., saturating counters updated after each instance) are well understood, these techniques do not translate directly to software techniques because changing a speculation requires changing the code. As it stands, the dominant software speculation control technique, non-reactive profile-guided optimization, lacks the robustness to support aggressive speculation. The primary thesis of this paper is that software speculation can be made to be robust by adding a reactive controller that can dynamically adjust the speculation. We make two primary observations about such systems: 1) reactive control systems can select behaviors on which to speculate with performance that equals or exceeds self-training, and 2) such control systems are remarkably latency tolerant. Although reactivity is required, it can be done at a low frequency; latencies of hundreds of thousands, or even millions of cycles, can be tolerated for most actions. Together these two characteristics imply that robust aggressive software speculation is a realistic goal.
Titles versus titles and abstracts for initial screening of articles for systematic reviews

Background There is no consensus on whether screening titles alone or titles and abstracts together is the preferable strategy for inclusion of articles in a systematic review. Methods Two methods of screening articles for inclusion in a systematic review were compared: titles first versus titles and abstracts simultaneously. Each citation found in MEDLINE or Embase was reviewed by two physician reviewers for prespecified criteria: the citation included (1) primary data; (2) the exposure of interest; and (3) the outcome of interest. Results There were 2965 unique citations. The titles first strategy resulted in an immediate rejection of 2558 (86%) of the records after reading the title alone, requiring review of 239 titles and abstracts, and subsequently 176 full text articles. The simultaneous titles and abstracts review led to rejection of 2782 citations (94%) and review of 183 full text articles. Interreviewer agreement to include an article for full text review using the titles-first screening strategy was 89%–94% (kappa = 0.54) and 96%–97% (kappa = 0.56) for titles and abstracts combined. The final systematic review included 13 articles, all of which were identified by both screening strategies (yield 100%, burden 114%). Precision was higher in the titles and abstracts method (7.1% versus 3.2%) but recall was the same (100% versus 100%), leading to a higher F-measure for the titles and abstracts approach (0.1327 versus 0.0619). Conclusion Screening via a titles-first approach may be more efficient than screening titles and abstracts together.
Emotional Intelligence in the Classroom: Skill-Based Training for Teachers and Students.

Successful schools ensure that all students master basic skills such as reading and math and have strong backgrounds in other subject areas, including science, history, and foreign language. Recently, however, educators and parents have begun to support a broader educational agenda – one that enhances teachers’ and students’ social and emotional skills. Research indicates that social and emotional skills are associated with success in many areas of life, including effective teaching, student learning, quality relationships, and academic performance. Moreover, a recent meta-analysis of over 300 studies showed that programs designed to enhance social and emotional learning significantly improve students’ social and emotional competencies as well as academic performance. Incorporating social and emotional learning programs into school districts can be challenging, as programs must address a variety of topics in order to be successful. One organization, the Collaborative for Academic, Social, and Emotional Learning (CASEL), provides leadership for researchers, educators, and policy makers to advance the science and practice of school-based social and emotional learning programs. According to CASEL, initiatives to integrate programs into schools should include training on social and emotional skills for both teachers and students, and should receive backing from all levels of the district, including the superintendent, school principals, and teachers. Additionally, programs should be field-tested, evidence-based, and founded on sound
Gang scheduling for highly efficient, distributed multiprocessor systems

We have implemented a job scheduling system for workstation clusters and massively parallel systems with highly efficient message passing interconnects that supports space and time sharing through multiuser gang scheduling of parallel jobs. The system is available on the IBM-SP-2 cluster. It is highly modular, scalable and can easily be adapted to a variety of other MPP systems. The system supports various scheduling policies. We architect the system so that the time-sharing of processors avoids any significant serialization and extra resource consumption, but preserves the reliability and the efficiency of the high performance communication subsystem that characterizes a dedicated non time shared systems.
WordNet: A Lexical Database for English

Because meaningful sentences are composed of meaningful words, any system that hopes to process natural languages as people do must have information about words and their meanings. This information is traditionally provided through dictionaries, and machine-readable dictionaries are now widely available. But dictionary entries evolved for the convenience of human readers, not for machines. WordNet1 provides a more effective combination of traditional lexicographic information and modern computing. WordNet is an online lexical database designed for use under program control. English nouns, verbs, adjectives, and adverbs are organized into sets of synonyms, each representing a lexicalized concept. Semantic relations link the synonym sets [4].
The Prevalence of Paraphilic Interests and Behaviors in the General Population: A Provincial Survey

Paraphilic sexual interests are defined as unusual or anomalous, but their actual occurrence in nonclinical samples is still unknown. This study looked at desire for and experience of paraphilic behaviors in a sample of adult men and women in the general population. A secondary goal was to compare the results of two survey modes—traditional landline telephone versus online. A total of 1,040 persons classified according to age, gender, education, ethnic background, religious beliefs, area of residency, and corresponding to the norm for the province of Quebec were interviewed. Nearly half of this sample expressed interest in at least one paraphilic category, and approximately one-third had had experience with such a practice at least once. Voyeurism, fetishism, frotteurism, and masochism interested both male and female respondents at levels above what is usually considered to be statistically unusual (15.9%). Interestingly, levels of interest in fetishism and masochism were not significantly different for men and women. Masochism was significantly linked with higher satisfaction with one’s own sexual life. As expected, the online mode generated more acknowledgment of paraphilic interest than the telephone mode. These results call into question the current definition of normal (normophilic) versus anomalous (paraphilic) sexual behaviors.
Ataxia Telangiectasia Mutated (ATM) Is Essential for DNA-PKcs Phosphorylations at the Thr-2609 Cluster upon DNA Double Strand Break*

The catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) is rapidly phosphorylated at the Thr-2609 cluster and Ser-2056 upon ionizing radiation (IR). Furthermore, DNA-PKcs phosphorylation at both regions is critical for its role in DNA double strand break (DSB) repair as well as cellular resistance to radiation. IR-induced DNA-PKcs phosphorylation at Thr-2609 and Ser-2056, however, exhibits distinct kinetics indicating that they are differentially regulated. Although DNA-PKcs autophosphorylates itself at Ser-2056 after IR, we have reported here that ATM mediates DNA-PKcs phosphorylation at Thr-2609 as well as at the adjacent (S/T)Q motifs within the Thr-2609 cluster. In addition, our data suggest that DNA-PKcs- and ATM-mediated DNA-PKcs phosphorylations are cooperative and required for the full activation of DNA-PKcs and the subsequent DSB repair. Elimination of DNA-PKcs phosphorylation at both regions severely compromises radioresistance and DSB repair. Finally, our result provides a possible mechanism for the direct involvement of ATM in non-homologous end joining-mediated DSB repair.
Adaptive Packet Combining for IPv6 soft handover applied to Network Mobility

Seamless vertical handover is one of the major challenges toward seamless inter-networking between heterogeneous access networks. To perform seamless vertical handover even under bad radio conditions in network mobility (NEMO) environments, NEMO-SHO has been proposed as an IPv6 soft handover extension that allows packet bicasting via two different wireless links simultaneously. However, the performance gain for TCP traffic was limited because spurious TCP retransmissions were invoked due to the difference of bandwidth and transmission delay between the two links. This paper proposes adding flow control to the packet combining process in NEMO-SHO, which is called adaptive packet combining. Adaptive packet combining estimates packet arrival time from a slow link and delays packets coming from a fast link based on the estimation, which can hide the difference of bandwidth and transmission delay between two links from TCP without any modification on nodes inside a moving network. Adaptive packet combining is thus able to reduce spurious TCP retransmissions. Using 3G and IEEE802.11b link, our experiments show that adaptive packet combining achieves better TCP goodput than Make-Before-Break handover under lossy radio conditions.
Regulation of the Rat Oxytocin Gene by Estradiol

Oxytocin (OT) plays a role in reproduction at the level of the pituitary and mammary glands and uterus. This OT is synthesized in the hypothalamo‐neurohypophyseal system (HNS). A number of observations have suggested that estrogens regulate the production of OT in the HNS. In this study the effect of 17β‐estradiol on the activity of the OT gene promoter was examined as well as the effect of 17β‐estradiol in vivo on OT messenger ribonucleic acid (mRNA) and peptide revels in the rat HNS. Vasopressin (VP) and its mRNA were also determined in the in vivo studies. The direct transcriptional stimulation of OT gene expression by 17β‐estradiol was studied in two different heterologous expression systems. When a plasmid having nucleotides −363 to +16 of the rat OT gene fused to the firefly luciferase reporter gene was co‐transfected with an estrogen receptor expression vector in P19 embryonal carcinoma cells, luciferase activity was stimulated 80‐fold by 17β‐estradiol. In estrogen receptor containing MCF‐7 cells transfected with a plasmid having nucleotides −188 to +16 of the rat OT gene fused to the chloramphenicol acetyl transferase gene, 17β‐estradiol induced the expression of the chloramphenicol acetyl transferase gene through the cloned promoter element. After in vivo treatment of ovariectomized rats with 17β‐estradiol, levels of OT mRNA and VP mRNA were measured in microdissected supraoptic and paraventricular nuclei as well as VP and OT levels in these nuclei and the pituitary gland. As compared to non‐treated ovariectomized rats there was no difference in contents of OT mRNA and VP mRNA in these hypothalamic nuclei and in levels of the peptides in paraventricular nuclei and the pituitary gland. A 30% reduction of the OT content of the supraoptic nuclei only was found, while the VP content did not change. To explain the results immunocytochemical analyses of the hypothalamus were performed, showing that the estrogen receptor was absent in the magnocellular neurons of the supraoptic and paraventricular nuclei. The results demonstrate that the 5’flanking region of the OT gene confers estrogen‐sensitivity to transcription of the OT gene. This potential to respond to estrogens is not used in the OT‐producing neurons of supraoptic and paraventricular nuclei probably due to the absence of the estrogen receptor.
SPFTN: A Self-Paced Fine-Tuning Network for Segmenting Objects in Weakly Labelled Videos

Object segmentation in weakly labelled videos is an interesting yet challenging task, which aims at learning to perform category-specific video object segmentation by only using video-level tags. Existing works in this research area might still have some limitations, e.g., lack of effective DNN-based learning frameworks, under-exploring the context information, and requiring to leverage the unstable negative video collection, which prevent them from obtaining more promising performance. To this end, we propose a novel self-paced fine-tuning network (SPFTN)-based framework, which could learn to explore the context information within the video frames and capture adequate object semantics without using the negative videos. To perform weakly supervised learning based on the deep neural network, we make the earliest effort to integrate the self-paced learning regime and the deep neural network into a unified and compatible framework, leading to the self-paced fine-tuning network. Comprehensive experiments on the large-scale YouTube-Objects and DAVIS datasets demonstrate that the proposed approach achieves superior performance as compared with other state-of-the-art methods as well as the baseline networks and models.
Adenovirus-mediated gene delivery into mouse spermatogonial stem cells

Spermatogonial stem cells represent a self-renewing population of spermatogonia, and continuous division of these cells supports spermatogenesis throughout the life of adult male animals. Previous attempts to introduce adenovirus vectors into spermatogenic cells, including spermatogonial stem cells, have failed to yield evidence of infection, suggesting that male germ cells may be resistant to adenovirus infection. In this study we show the feasibility of transducing spermatogonial stem cells by adenovirus vectors. When testis cells from ROSA26 Cre reporter mice were incubated in vitro with a Cre-expressing adenovirus vector, Cre-mediated recombination occurred at an efficiency of 49–76%, and the infected spermatogonial stem cells could reinitiate spermatogenesis after transplantation into seminiferous tubules of infertile recipient testes. No evidence of germ-line integration of adenovirus vector could be found in offspring from infected stem cells that underwent Cre-mediated recombination, which suggests that the adenovirus vector infected the cells but did not stably integrate into the germ line. Nevertheless, these results suggest that adenovirus may inadvertently integrate into the patient's germ line and indicate that there is no barrier to adenovirus infection in spermatogonial stem cells.
Detection of GRB 060927 at z = 5.47: Implications for the Use of Gamma-Ray Bursts as Probes of the End of the Dark Ages

We report on follow-up observations of the gamma-ray burst GRB 060927 using the robotic ROTSE-IIIa telescope and a suite of larger aperture ground-based telescopes. An optical afterglow was detected 20 s after the burst, the earliest rest-frame detection of optical emission from any GRB. Spectroscopy performed with the VLT about 13 hr after the trigger shows a continuum break at λ ≈ 8070 Å, produced by neutral hydrogen absorption at z ≈ 5.6. We also detect an absorption line at 8158 Å, which we interpret as Si II λ1260 at z = 5.467. Hence, GRB 060927 is the second most distant GRB with a spectroscopically measured redshift. The shape of the red wing of the spectral break can be fitted by a damped Lyα profile with a column density with log(NH /cm-2) = 22.50 ± 0.15. We discuss the implications of this work for the use of GRBs as probes of the end of the dark ages and draw three main conclusions: (1) GRB afterglows originating from z ≳ 6 should be relatively easy to detect from the ground, but rapid near-infrared monitoring is necessary to ensure that they are found; (2) the presence of large H I column densities in some GRB host galaxies at z > 5 makes the use of GRBs to probe the reionization epoch via spectroscopy of the red damping wing challenging; and (3) GRBs appear crucial to locate typical star-forming galaxies at z > 5, and therefore the type of galaxies responsible for the reionization of the universe.
The Effects of Cyclooxygenase and Lipoxygenase Inhibitors on the Collagen Abnormalities of Diabetic Rats

The importance of cyclooxygenase and lipoxygenase pathways in the determination of collagen abnormalities in diabetes was investigated. Pharmacological agents with antiprostaglandin activity, such as indomethacin, naproxen, and aspirin, were able to prevent the rise in thermal rupture time of tail collagen in diabetic rats. Paracetamol was without effect. The action of indomethacin on diabetic collagen was abolished by concurrent administration of sodium benoxaprofen, an inhibitor of lipoxygenase, to the diabetic rats. Collagen abnormalities in diabetes may be regulated by a balance of the cyclooxygenase and lipoxygenase pathways. Antiprostaglandin agents may have a role in the prevention of some diabetic complications.
A study of the effectiveness of usage examples in REST API documentation

Generating and maintaining REST API documentation with usage examples can be a time consuming and expensive process for evolving APIs. Most REST API documentation tools focus on automating the documentation of the API objects, but require manual effort for capturing usage examples. Consequently, REST API developers need to know the cost vs. benefit of providing usage examples in the documentation to prioritize the documentation efforts. To this end, we have performed a controlled study with 26 experienced software engineers to understand problems that REST API client developers face while using an API without usage examples. We found that REST API client developers face productivity problems with using correct data types, data formats, required HTTP headers and request body when documentation lacks usage examples. By following the REST API documentation suggestions from this paper, REST API developers can reduce the errors, improve success rate and satisfaction of API client developers.