Miracle-dz/UniFAR-FTUs huggingface dataset:
Electrophysiological Responses to Expectancy Violations in Semantic and Gambling Tasks: A Comparison of Different EEG Reference Approaches

Dynamically evaluating the outcomes of our actions and thoughts is a fundamental cognitive ability. Given its excellent temporal resolution, the event-related potential (ERP) technology has been used to address this issue. The feedback-related negativity (FRN) component of ERPs has been studied intensively with the averaged linked mastoid reference method (LM). However, it is unknown whether FRN can be induced by an expectancy violation in an antonym relations context and whether LM is the most suitable reference approach. To address these issues, the current research directly compared the ERP components induced by expectancy violations in antonym expectation and gambling tasks with a within-subjects design and investigated the effect of the reference approach on the experimental effects. Specifically, we systematically compared the influence of the LM, reference electrode standardization technique (REST) and average reference (AVE) approaches on the amplitude, scalp distribution and magnitude of ERP effects as a function of expectancy violation type. The expectancy deviation in the antonym expectation task elicited an N400 effect that differed from the FRN effect induced in the gambling task; this difference was confirmed by all the three reference methods. Both the amplitudes of the ERP effects (N400 and FRN) and the magnitude as the expectancy violation increased were greater under the LM approach than those under the REST approach, followed by those under the AVE approach. Based on the statistical results, the electrode sites that showed the N400 and FRN effects critically depended on the reference method, and the results of the REST analysis were consistent with previous ERP studies. Combined with evidence from simulation studies, we suggest that REST is an optional reference method to be used in future ERP data analysis.
Genetic variant in visfatin gene promoter contributes to reduced risk of hepatocellular carcinoma in a Chinese population

Knowledge on the role of gene variants in the visfatin promoter region in the hepatitis B virus (HBV)-related liver diseases is limited. In this study, we genotyped two potentially functional single nucleotide polymorphisms (SNPs) in the visfatin promoter region, -1535C>T (rs61330082) and -3187G>A (rs11977021), in 120 HBV-related chronic hepatitis B (CHB) patients, 140 HBV-related liver cirrhosis (HBV-LC) patients, 243 HBV-related hepatocellular carcinoma (HBV-HCC) patients, and 224 asymptomatic HBV carriers. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated by logistic regression. The results showed subjects with a TT genotype of -1535C>T had a significantly decreased risk of HBV-HCC related to the CC and CC + CT genotypes (adjusted OR = 0.493, 95% CI = 0.313-0.778; OR = 0.535, 95% CI = 0.362-0.791, respectively). A lowered risk also appeared in the comparison between allele T and allele C (OR = 0.734, 95%, CI = 0.581-0.950). However, these associations existed only in people with Zhuang ethnicity, but not in people with Han ethnicity. There were no significant associations between -3187G>A polymorphisms and the risk of HBV-related liver diseases. Our results suggested that visfatin -1535C>T polymorphisms might be associated with decreased risk of HBV-HCC among the ethnic Zhuang population in Guangxi, China.
Spread of Information With Confirmation Bias in Cyber-Social Networks

This paper provides a model to investigate information spread over cyber-social network of agents. The cyber-social network considered here comprises individuals and information sources. Each individual holds an opinion represented by a scalar that evolves over time. The information sources are stubborn, in the sense that their opinions are time-invariant. Individuals receive the opinions of information sources that are closer to their belief, confirmation bias is explicitly incorporated into the model. The proposed dynamics of cyber-social networks is adopted from DeGroot-Friedkin model, where an individual's opinion update mechanism is a convex combination of her innate opinion, her neighbors’ opinions at the previous time step (obtained from the social network), and the opinions passed along by information sources from cyber layer which she follows. The characteristics of the interdependent social and cyber networks are significantly different here: the social network relies on trust and hence static, while influences from information sources to individuals are highly dynamic since they are weighted as a function of the distance between an individual state and the state of information source to account for confirmation bias. The conditions for convergence of the aforementioned dynamics to a unique equilibrium point are characterized. The estimation and exact computation of the steady-state values under non-linear and linear state-dependent weight functions are provided. Finally, the impact of polarization in the opinions of information sources on the public opinion evolution is numerically analyzed in the context of the well-known Krackhardt's advice network.
Miniature Piezoelectric Sensor for In-Situ Temperature Monitoring of Silicon and Silicon Carbide Power Modules Operating at High Temperature

Owing to the introduction of wide-bandgap power devices, recent power modules operate at higher temperatures. This increased module temperature leads to significant reliability problems, which render thermal monitoring very important. Several thermal sensors have been used in power modules; however, each of these sensors has drawbacks such as limited maximum temperature, nonlinearity, power source requirement, or limited miniaturization. This paper proposes a new temperature sensor that utilizes the piezoelectric effect. A new piezoelectric material (PZT-PZNM) with a high Curie temperature (260 °C) is soldered onto a direct bonded copper substrate. When the power module is operating at a high temperature, the substrate deflects and induces thermal stress, which is converted into an electric voltage via a piezoelectric mechanism. The voltage can be maximized by optimizing the location of the PZT-PZNM; the best location was determined to be away from the power devices. This observation confirms that the piezoelectric temperature sensor has a negligible influence on the performance of the power devices. Moreover, the sensor volume was miniaturized (approximately 74% reduction compared with preliminary work) to ensure that it can be readily integrated into power modules. The developed piezoelectric sensor demonstrates excellent linearity ( R2 = 0.99, approximately) up to 250 °C, which is sufficient for monitoring temperature in both silicon and silicon carbide power modules.
A comparison of open-loop and closed-loop adaptive calibration for pattern recognition based myoelectric control

This study presented a closed-loop adaptive calibration (CLAC) scheme where subjects could get instantaneous feedback of their movements and alter their motions immediately to update the model parameters to enhance its ability. The real-time performance was compared between the conventional open-loop calibration (OLC) and the presented CLAC based on three metrics (motion-selection time, motion-completion time and motion-completion rate). The CLAC performed slightly better than the OLC, but the difference was not significant. This was the first study designed to investigate the effects of CLAC for pattern recognition-based myoelectric control (discrete movement). The CLAC could be potentially applied in the multiuser interface to make the adaptation of the common model to a novel user efficiently and flexibly.
New Results on the Fluctuating Two-Ray Model With Arbitrary Fading Parameters and Its Applications

The fluctuating two-ray (FTR) fading model provides a much better fit than other fading models for small-scale fading measurements in millimeter wave communications. In this paper, using a mixture of gamma distributions, new exact analytical expressions for the probability density and cumulative distribution functions of the FTR distribution with arbitrary fading parameters are presented. Moreover, the performance of digital communication systems over the FTR fading channel is evaluated in terms of the channel capacity and the bit error rate. The interaction between channel fading parameters and system performance is further investigated. Our newly derived results extend and complement previous knowledge of the FTR fading model.
Microplastics Reduce Short-Term Effects of Environmental Contaminants. Part II: Polyethylene Particles Decrease the Effect of Polycyclic Aromatic Hydrocarbons on Microorganisms

Microplastic particles in terrestrial and aquatic ecosystems are currently discussed as an emerging persistent organic pollutant and as acting as a vector for hydrophobic chemicals. Microplastic particles may ultimately deposit and accumulate in soil as well as marine and freshwater sediments where they can be harmful to organisms. In this study, we tested the sensitivity of natural freshwater sediment bacterial communities (by genetic fingerprint) to exposure to microplastics (polyethylene, 2 and 20 mg/g sediment) and microplastics loaded with polycyclic aromatic hydrocarbons (PAHs, phenanthrene and anthracene), using a laboratory-based approach. After two weeks of incubation, the bacterial community composition from an unpolluted river section was altered by high concentrations of microplastics, whereas the community downstream of a wastewater treatment plant remained unchanged. Low microplastic concentrations loaded with phenanthrene or anthracene induced a less pronounced response in the sediment communities compared to the same total amount of phenanthrene or anthracene alone. In addition, biodegradation of the PAHs was reduced. This study shows, that microplastic can affect bacterial community composition in unpolluted freshwater sediments. Moreover, the results indicate that microplastics can serve as a vehicle for hydrophobic pollutants but bioavailability of the latter is reduced by the sorption to microplastics.
Observing and Giving Feedback to Novice PGY-1s

Objectives In this new era of educational milestones and entrustable professional activities, residency programs have recognized the need to directly observe resident performance. In fact, there is little information about how often residents are observed, what procedures they perform early in training, and whether they receive feedback. Previous publications have addressed these issues exclusively through retrospective survey analyses. The purpose of this naturalistic point-of-care study was to answer the following questions about obstetrics/gynecology (OB/GYN) residents in their second month of training: what activities do residents report performing, how often are they observed and who observes them, how often do they receive feedback and what is their perception of its usefulness, and does the time of shift affect the frequency of observation and feedback? Methods Nine of 10 first-year OB/GYN residents at George Washington University Hospital participated in a month-long study during their second month of training. Based on point-of-care experiences, participants prospectively recorded the time of shift, activities performed, the person who observed them, whether they received feedback, and whether it was perceived as helpful. Results First-year OB/GYN residents (postgraduate year 1 [PGY-1]) perform a variety of activities early in training while being observed by senior residents, nurses, and attending physicians 70% of the time. Residents commented that feedback was helpful almost every time they received it, regardless of who provided the feedback. There were no significant differences in the quantity of observations and feedback received between day and night shifts; however, nurses and senior residents were most likely to observe residents during night shifts. Conclusions In this naturalistic pilot study, OB/GYN residents reported performing various procedures in their second month of training, with some observations from faculty, senior residents, and nurses. Feedback, as defined in the study, is an important aspect of their early training, although it is not reported with each patient encounter. This pilot study raises critical issues that need further study, such as the following: What should be the gold standard for observing residents around a particular activity? Where should the bar be set for types and numbers of procedures that residents perform early on in training, either with patients or in simulations? What is an acceptable feedback rate around patient encounters? Should we not consider training nurses and senior residents to deliver effective feedback to residents as part of a 360-degree process, because many trainees were observed most frequently by these members of the medical team?
The expression and mechanism of Sirt1 and AMPK in nonsmall cell lung cancer.

PURPOSE To investigate the expression of sirtuin type 1 (Sirt1) and adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK) in non-small cell lung cancer (NSCLC), and to explore the mechanism of their functions in NSCLC. METHODS Cancer tissues (NSCLC group) and the adjacent normal healthy tissues (control group) of 50 patients with NSCLC were selected, and H&E staining was performed to identify the histopathological differences. Reverse transcription polymerase chain reaction (RT-PCR), immunofluorescence staining and Western blot were performed to detect the expression of Sirt1 and AMPK in tissues of NSCLC group and control group. SPSS17.0 statistical software was used to analyze the differences in the expression of Sirt1 and AMPK between control group and NSCLC group. RESULTS Significant differences in histopathological structure were found between NSCLC and control group by H&E staining. Compared with control group, cell structure in NSCLC group was destroyed and condensed nuclei were observed, indicating the lung injury. Results of RT-PCR, immunofluorescence staining and Western blot showed that the expression levels of Sirt1 and AMPK were significantly lower in the NSCLC group than in the control group at both mRNA and protein levels. Results of variance analysis showed significant differences in the expression levels of Sirt1 and AMPK between control group and NSCLC group (p<0.01). CONCLUSION The abnormal expression of Sirt1 and AMPK was closely related to the occurrence and development of NSCLC.
Prevalence and predictors of symptoms of anxiety and depression, and comorbid symptoms of distress in parents of childhood cancer survivors and bereaved parents five years after end of treatment or a child’s death

Abstract Background: Symptoms of anxiety and depression and their comorbidity in parents of children diagnosed with cancer, particularly later in the cancer trajectory, need further study. The aim was to investigate the prevalence and predictors of symptoms of anxiety and depression in parents of childhood cancer survivors and bereaved parents, five years after end of treatment or a child’s death and to investigate comorbidity between symptoms of anxiety, depression and posttraumatic stress. Material and methods: Participants were 132 parents (68 mothers, 64 fathers) of survivors and 37 bereaved parents (20 mothers, 17 fathers). Chi-square test and t-test were used to explore differences in symptoms of anxiety and depression. Comorbidity was explored using Pearson’s correlations and Chi-square test. Multivariable hierarchical linear regressions were used to identify predictors of symptoms of anxiety and depression. Results: In parents of survivors, 20% reported anxiety and 14% reported depression. Corresponding figures among bereaved parents were 30% and 35%. Among parents of survivors reporting clinically relevant anxiety and depression, a larger proportion were mothers than fathers. No such difference was found among bereaved parents. Symptoms of anxiety, depression and posttraumatic stress were highly correlated (all r ≥ 0.65, p < .001). Comorbid symptoms were reported by 7–11% of parents of survivors and 14–24% of bereaved parents. In multivariable analyses, more severe symptoms of depression were associated with anxiety, posttraumatic stress and distress related to previous stressful life events. Being a mother, symptoms of depression and posttraumatic stress were associated with more severe symptoms of anxiety. Conclusion: A subset of parents report clinically elevated symptoms of anxiety and depression, comorbid anxiety, depression and posttraumatic stress. Experiencing distress related to previous stressful life events as well as concurrent comorbidity were associated with more severe psychological distress at five years after end of treatment/a child’s death. These results deserve further attention in research and clinical care.
Malware Analysis of Imaged Binary Samples by Convolutional Neural Network with Attention Mechanism

This paper presents a proposal of a method to extract important byte sequences in malware samples to reduce the workload of human analysts who investigate the functionalities of the samples. This method, by applying convolutional neural network (CNN) with a technique called attention mechanism to an image converted from binary data, enables calculation of an "attention map," which shows regions having higher importance for classification in the image. This distinction of regions enables extraction of characteristic byte sequences peculiar to the malware family from the binary data and can provide useful information for the human analysts without a priori knowledge. Furthermore, the proposed method calculates the attention map for all binary data including the data section. Thus, it can process packed malware that might contain obfuscated code in the data section. Results of our evaluation experiment using malware datasets show that the proposed method provides higher classification accuracy than conventional methods. Furthermore, analysis of malware samples based on the calculated attention maps confirmed that the extracted sequences provide useful information for manual analysis, even when samples are packed.
Correction to Supporting Information for Biswas et al., E-cadherin junction formation involves an active kinetic nucleation process

BIOPHYSICS AND COMPUTATIONAL BIOLOGY Correction to Supporting Information for “E-cadherin junction formation involves an active kinetic nucleation process,” by Kabir H. Biswas, Kevin L. Hartman, Cheng-han Yu, Oliver J. Harrison, Hang Song, Adam W. Smith, William Y. C. Huang, Wan-Chen Lin, Zhenhuan Guo, Anup Padmanabhan, Sergey M. Troyanovsky, Michael L. Dustin, Lawrence Shapiro, Barry Honig, Ronen Zaidel-Bar, and Jay T. Groves, which appeared in issue 35, September 1, 2015, of Proc Natl Acad Sci USA (112:10932–10937; first published August 19, 2015; 10.1073/ pnas.1513775112). The authors note that on page 1 of the Supporting Information, right column, second full paragraph, line 3, “0.004% BSA” originally appeared incorrectly as “0.01% BSA. ” The SI has been corrected online.
Prevalence of Oral Clefts among Live Births in Gansu Province, China

Background: Oral clefts (OCs) are common human birth defects. Children with OCs in underdeveloped regions are more likely to suffer from poverty and hardship in their future lives. Here, we attempted to estimate the prevalence of OCs among live births in Gansu Province in 2008 to understand the epidemiologic pattern of the disease. Methods: A cross-sectional study was conducted from January 2008 to December 2008 in Gansu Province. The live births delivered between January and December 2008 with OCs were investigated through face-to-face questionnaire survey. Results: A total of 468 infants with OCs were identified among 347,137 live births in 2008 in Gansu Province, which yielded a prevalence of 1.35 per 1000 live births. The majority of these cases were CL (cleft lip) (prevalence = 0.85 per 1000 live births), and the prevalence of CLP (cleft lip and palate) and CP (cleft palate) was 0.34 and 0.11 per 1000 live births, respectively. We also found that the prevalence of OCs in Jiayuguan (3.39 per 1000 live births) and Dingxi (2.71 per 1000 live births) was higher than those of other cities in Gansu Province. Additionally, we failed to detect significant correlation between economic conditions of the cities and the prevalence of OCs in our study. Conclusions: The prevalence of OCs among live births in Gansu Province in 2008 was higher than the prevalence of OCs in other provinces in China. The high prevalence may reflect the need for further etiological studies to explore the potential risk factors in this region. In addition, more subtype information needs to be collected in future prevalence studies for better understanding of the epidemiologic pattern of the disease.
Verbal fluency tests: Normative data for Spanish-speaking pediatric population.

OBJECTIVE To generate normative data for the phonological and semantic verbal fluency tests (VFT) in Spanish-speaking pediatric populations. METHOD The sample consisted of 4,373 healthy children from nine countries in Latin America (Chile, Cuba, Ecuador, Guatemala, Honduras, Mexico, Paraguay, Peru, and Puerto Rico) and Spain. Each participant was administered the VFT as part of a larger neuropsychological battery. Scores for letters F, A, S, and animals and fruit categories were normed using multiple linear regressions and standard deviations of residual values. Age, age2, sex, and mean level of parental education (MLPE) were included as predictors in the analyses. RESULTS The final multiple linear regression models showed main effects for age on all scores, such that scores increased linearly as a function of age. Age2 had a significant effect in Chile (animals), Cuba (A letter, fruits), Ecuador (animals, fruits), Honduras (F letter), Mexico (animals, fruits), Peru (fruits), and Spain (S letters, animals, fruits). Models showed an effect for MLPE in Chile (A letters, animals, fruits), Ecuador (S letter, animals, fruits), Guatelama (F, S letter, animals), Honduras (animals), Mexico (F, A, S letters, animals, fruits), Puerto Rico (A, letters, animals), and Spain (all scores). Sex scores were found significant in Chile (animals), Ecuador (A letter, fruits), Mexico (F letter, fruits), Paraguay (F, A, S letters, fruits), Puerto Rico (F letter, animals, fruits), and Spain (F letter, fruits). CONCLUSIONS This is the largest multi-national Spanish speaking-pediatric normative study in the world, and as such it will allow neuropsychologists from these countries to have a more accurate way to interpret the phonological and semantic VFT in pediatric populations.