Miracle-dz/UniFAR-FTUs huggingface dataset:
CANTINA+: A Feature-Rich Machine Learning Framework for Detecting Phishing Web Sites

Phishing is a plague in cyberspace. Typically, phish detection methods either use human-verified URL blacklists or exploit Web page features via machine learning techniques. However, the former is frail in terms of new phish, and the latter suffers from the scarcity of effective features and the high false positive rate (FP). To alleviate those problems, we propose a layered anti-phishing solution that aims at (1) exploiting the expressiveness of a rich set of features with machine learning to achieve a high true positive rate (TP) on novel phish, and (2) limiting the FP to a low level via filtering algorithms. Specifically, we proposed CANTINA+, the most comprehensive feature-based approach in the literature including eight novel features, which exploits the HTML Document Object Model (DOM), search engines and third party services with machine learning techniques to detect phish. Moreover, we designed two filters to help reduce FP and achieve runtime speedup. The first is a near-duplicate phish detector that uses hashing to catch highly similar phish. The second is a login form filter, which directly classifies Web pages with no identified login form as legitimate. We extensively evaluated CANTINA+ with two methods on a diverse spectrum of corpora with 8118 phish and 4883 legitimate Web pages. In the randomized evaluation, CANTINA+ achieved over 92% TP on unique testing phish and over 99% TP on near-duplicate testing phish, and about 0.4% FP with 10% training phish. In the time-based evaluation, CANTINA+ also achieved over 92% TP on unique testing phish, over 99% TP on near-duplicate testing phish, and about 1.4% FP under 20% training phish with a two-week sliding window. Capable of achieving 0.4% FP and over 92% TP, our CANTINA+ has been demonstrated to be a competitive anti-phishing solution.
Induction of Thyroid Gene Expression and Radioiodine Uptake in Melanoma Cells: Novel Therapeutic Implications

Both the MAP kinase and PI3K/Akt pathways play an important role in the pathogenesis of melanoma. We conducted the present study to test the hypothesis that targeting the two pathways to potently induce cell inhibition accompanied with thyroid iodide-handling gene expression for adjunct radioiodine ablation could be a novel effective therapeutic strategy for melanoma. We used specific shRNA approaches and inhibitors to individually or dually suppress the MAP kinase and PI3K/Akt pathways and examined the effects on a variety of molecular and cellular responses of melanoma cells that harbored activating genetic alterations in the two pathways. Suppression of the MAP kinase and PI3K/Akt pathways showed potent anti-melanoma cell effects, including the inhibition of cell proliferation, transformation and invasion, induction of G0/G1 cell cycle arrest and, when the two pathways were dually suppressed, cell apoptosis. Remarkably, suppression of the two pathways, particularly simultaneous suppression of them, also induced expression of genes that are normally expressed in the thyroid gland, such as the genes for sodium/iodide symporter and thyroid-stimulating hormone receptor. Melanoma cells were consequently conferred the ability to take up radioiodide. We conclude that dually targeting the MAP kinase and PI3K/Akt pathways for potent cell inhibition coupled with induction of thyroid gene expression for adjunct radioiodine ablation therapy may prove to be a novel and effective therapeutic strategy for melanoma.
Dense Alumina Ceramics Obtained by Gelcasting and Cold Isostatic Pressing with the Use of 2-Carboxyethyl Acrylate

In ceramic forming techniques high particles packing can provide better properties of the final ceramic products. The high quality of the material coupled with the shape complexity of the ceramic product is still challenging. The aim of this work was the optimization and preparation of the ceramic samples based on two alumina powders of different particle size (AA05: 0.5 μm and TM-DAR: 0.15 μm). Firstly, ceramic suspensions of 50vol. % solid loading and the volumetric ratio of AA05 to TM-DAR 1:1, 2:1, 3:1, 4:1, respectively have been prepared. The 2-carboxyethyl acrylate was applied as the new monomer limiting the negative effect of oxygen inhibition. Additionally, the cold isostatic pressing (CIP) was used in order to increase relative density of green bodies. The results of presented research have shown that samples with the ratio of AA05 to TM-DAR 2:1 were characterized by the highest green density (62%). Moreover, CIP process proved to be effective and increased the density of green bodies from 62% to 67%. The pore size distribution of the green bodies has been measured. Samples were sintered at different conditions (1400°C, 1450°C and 1500°C for 1h and 1300°C, 1400°C, 1450°C and 1500°C for 5h).
Persistent Nasal Carriage of Staphylococcus aureus Is Associated with Deficient Induction of Human β-Defensin 3 after Sterile Wounding of Healthy Skin In Vivo

ABSTRACT Persistent nasal carriage of Staphylococcus aureus is the primary reservoir for this pathogen and a risk factor for infection. The nares of 12 to 30% of healthy individuals are persistently colonized with staphylococci. Elucidating the yet enigmatic determinants of this phenomenon is of major public health interest. We hypothesized that differences in the levels of antimicrobial peptides (AMPs) that are found in human skin and have pronounced antistaphylococcal activity may contribute to this phenomenon. We compared constitutive and induced mRNA levels of RNase 7 and human β-defensin 3 (HBD-3) in healthy and experimentally wounded gluteal skin of 60 volunteers after ascertaining their carrier status through repeated nasal cultures. We found that levels of HBD-3 expression in skin of persistent nasal carriers of S. aureus were lower: induced levels in carriers were 63% (95% confidence interval, 43 to 94%; P = 0.02) and constitutive levels were 76% (95% confidence interval, 52 to 110%; P = 0.14) of those found in noncarriers. No such associations were present for RNase 7. In conjunction with existing knowledge, these findings suggest that healthy individuals with deficient HBD-3 expression in keratinocytes are more prone to persistent nasal colonization with S. aureus.
Immunization of metastatic breast cancer patients with a fully synthetic globo H conjugate: A phase I trial

The carbohydrate antigen globo H commonly found on breast cancer cells is a potential target for vaccine therapy. The objectives of this trial were to determine the toxicity and immunogenicity of three synthetic globo H-keyhole limpet hemocyanin conjugates plus the immunologic adjuvant QS-21. Twenty-seven metastatic breast cancer patients received five vaccinations each. The vaccine was well tolerated, and no definite differences were observed among the three formulations. Serologic analyses demonstrated the generation of IgM antibody titers in most patients, with minimal IgG antibody stimulation. There was significant binding of IgM antibodies to MCF-7 tumor cells in 16 patients, whereas IgG antibody reactivity was observed in a few patients. There was evidence of complement-dependent cytotoxicity in several patients. Affinity column purification supported the specificity of IgM antibodies for globo H. On the basis of these data, globo H will constitute one component of a polyvalent vaccine for evaluation in high-risk breast cancer patients.
Enhancing the quality of peer review by reducing student "free riding": Peer assessment with positive interdependence

Abstract Collaborative learning tasks have been hampered by problems of unequal participation such as the presence of a free rider or dominance by a member of a group. Researchers in the collaborative learning domain respond to these problems with approaches designed to establish personal accountability for each student and relations of positive interdependence between students. These two notions have been borrowed and integrated with the present approach, which is designed for use in both traditional and online peer assessment. The key assumption is that introducing a greater degree of positive interdependence and personal accountability into the assessment process may reduce or eliminate free riding, while with students performing their ratings individually, dominance is unlikely to be an issue. Practitioner Notes What is already known about this topic • A number of studies have found generally positive results for peer assessment. • When implementing peer assessment, teachers are faced with a number of threats, including favoritism, unfairness, distortion of marking, low-quality comments and a lack of engagement. • Numerous peer assessment tools have been developed to make assessment more fair for students. What this paper adds • The focus of this paper is on countering the threats of carelessness and favoritism. • The paper describes an innovative approach called “Peer Assessment with Positive Interdependence” (PAPI), which was designed to counter these threats and enhance the overall quality of peer review. • The PAPI approach encourages students to take a broader and more comprehensive perspective during peer assessment, enhancing their ability as “critical assessors. ” Implications for practice and/or policy • PAPI enables students to benefit from the known advantages of peer assessment while minimizing threats to its effectiveness. • PAPI makes it possible to target particular instructional goals, through the use of different weightings at different stages of the learning process. • In particular, if teaching a class in which most students are “quality achievers” with only a few “critical assessors” teachers might adjust the weightings to promote the development of critical thinking skills. • Conversely, if the class contains a high number of “critical assessors” but only a small number of “quality achievers,” the weightings could be adjusted to focus more on the individual assignments.
Gender and the relationship between ventricular repolarization and cardiac cycle length during 24-h Holter recordings.

AIMS There are gender-related differences in the QT interval measured from standard ECG tracings. However, these observations are based on a limited number of beats recorded in resting conditions. Computerized Holter techniques enable ventricular repolarization and its relationship with cardiac cycle length to be analysed long term. Previous studies used only the initial portion of the QT interval to the T wave apex (QTa) to measure ventricular repolarization; however, QTa may underestimate the total QT duration (QTe). The aims of this study were to verify whether QTa and QTe had similar rate-dependence in normal subjects and whether gender-related QTe differences observed in the resting ECG were also present in the long-term QT intervalcycle length relationship. METHODS AND RESULTS Twenty-four hour Holter recordings were obtained in 40 healthy young subjects. 20 females and 20 males (mean age 28 +/- 9 and 26 +/- 5 years, respectively ns). Two-channel ECG digitized signals were processed using new automatic QT analysis software (Ela Medical), which converted the 24-h recordings into 2880 30-s templates. It also measured the QT apex (QTa) QT end (QTe) and the RR interval (ms) of each template, and computed the slopes of the linear regressions of QTe and QTa values plotted against the corresponding RR interval (QTe/RR and QTa/RR). Females had a shorter RR interval than males (803 +/- 129 vs 877 +/- 86 ms. P = 0.037), with longer mean QTc (420 +/- 17 vs 400 +/- 200 ms. P = 0.0005). In both genders. QTa/RR slopes were steeper than QTe/RR slopes (P = 0.0001). Both QTa/RR and QTe/RR slopes were steeper in females than in males (QTa/RR 0.20 +/- 0.04 vs 0.16 +/- 0.03, P = 0.001; QTe/RR 0.16 +/- 0.04 vs 0.13 +/- 0.03, P = 0.027). Of note, QTa and QTe at fixed long cycle lengths (1000 ms) were longer in women than in men (QTa1000 330 +/- 20 vs 309 +/- 18 ms: P = 0.002; QTe1000 410 +/- 17 vs 389 +/- 19 ms: P = 0.002), while they did not differ at fixed short cycle lengths (600 ms). CONCLUSIONS This study demonstrates that both the initial portion of the QT interval (QTa) and the entire QT interval (QTe) are useful since QTa is more prolonged than QTe at increasing cycle lengths, and thus includes most of the heart rate dependency of ventricular repolarization. In normal subjects, both the QTc and the long-term relationship between ventricular repolarization and heart rate are affected by gender. The differences in QTa and QTe duration between males and females are more marked at long cycle lengths and disappear at short cycle lengths. Finally, this study also proves the clinical feasibility of assessing the long-term relationship between ventricular repolarization and heart rate by utilizing the automatic measurement of the QT interval from 24-h Holter recordings.
Rapid fibrosis progression among HIV/hepatitis C virus-co-infected adults

Objectives:To define the incidence of fibrosis progression among hepatitis C virus (HCV)/HIV-co-infected adults, to assess whether HCV or HIV treatment alters the risk of progression, and to determine the utility of liver biopsy to predict future disease. Design:This prospective cohort evaluated 184 HIV/HCV-co-infected individuals who had at least two liver biopsies (median interval 2.9 years). Methods:Biopsies were scored according to the Ishak modified histological activity index scoring system by a single pathologist blind to biopsy sequence. Significant fibrosis progression was defined as an increase of at least two Ishak fibrosis units between the first and second liver biopsy. Logistic regression analysis was used to assess determinants of fibrosis progression. Results:A total of 174 non-cirrhotic patients were eligible; the majority were African-American men undergoing HIV treatment. On initial biopsy, no or minimal fibrosis was identified in 136 patients (77%). Significant fibrosis progression occurred in 41patients (24%). Measures of HIV disease and its treatment before and after initial biopsy were not significantly different in progressors and non-progressors. Fibrosis progression was not associated with HCV treatment, which was received by 37 patients (21%) but only three sustained HCV-RNA suppression. In adjusted analysis, only an elevated serum aspartate aminotransferase level between biopsies was associated with progression (odd ratio 3.4, 95% confidence interval 1.4–7.9). Conclusion:Over a 3-year interval, significant fibrosis progression can occur in co-infected individuals even if minimal disease was detected on initial biopsy. In this context, factors other than treatment for HIV or HCV modify the risk of fibrosis progression.
The Oxford Handbook of Philosophy of Social Science

The philosophy of the social sciences considers the underlying explanatory powers of the social (or human) sciences, such as history, economics, anthropology, politics, and sociology. The type of questions covered includes the methodological (the nature of observations, laws, theories, and explanations) to the ontological -- whether or not these sciences can explain human nature in a way consistent with common-sense beliefs. This Handbook is a major, comprehensive look at the key ideas in the field, is guided by several principles. The first is that the philosophy of social science should be closely connected to, and informed by, developments in the sciences themselves. The second is that the volume should appeal to practicing social scientists as well as philosophers, with the contributors being both drawn from both ranks, and speaking to ongoing controversial issues in the field. Finally, the volume promotes connections across the social sciences, with greater internal discussion and interaction across disciplinary boundaries. Available in OSO: http://www.oxfordhandbooks. com/oso/public/content/oho_philosophy/9780195392753/toc.html
Trends in Racial and Ethnic Disparities in Antiretroviral Therapy Prescription and Viral Suppression in the United States, 2009–2013

Objectives:To examine trends in racial/ethnic disparities in antiretroviral therapy (ART) prescription and viral suppression among HIV-infected persons in care, overall and among men who have sex with men (MSM), from 2009 to 2013. Design:The Medical Monitoring Project (MMP) is a complex sample survey of HIV-infected adults receiving medical care in the United States. Methods:We used weighted interview and medical record data collected June 2009–May 2014 to estimate the prevalence of ART prescription and viral suppression among racial/ethnic groups overall and among MSM. Results:We found significant increases in ART prescription and viral suppression among all racial/ethnic groups from 2009 to 2013, both overall and among MSM. By 2013, overall and among MSM, the Hispanic–white disparity in ART prescription was nonexistent, and the black–white disparity was not significant after accounting for differences between blacks and whites in age and length of HIV diagnosis. Despite reductions in racial/ethnic disparities in viral suppression over the time period, significant disparities remained among the total population, even after adjusting for differences in racial/ethnic group characteristics. Encouragingly, however, there was no significant Hispanic–white disparity in viral suppression among MSM by 2013. Conclusions:Despite significant improvements in ART prescription and viral suppression in recent years, racial and ethnic disparities persist, particularly for black persons. If the United States is to achieve the National HIV/AIDS Strategy goal of reducing HIV-related health disparities, continued efforts to accelerate the rate of improvement in ART prescription and viral suppression among Hispanic and black persons may need to be prioritized.
Unusual modes of reproduction in social insects: Shedding light on the evolutionary paradox of sex

The study of alternative genetic systems and mixed modes of reproduction, whereby sexual and asexual reproduction is combined within the same lifecycle, is of fundamental importance as they may shed light on classical evolutionary issues, such as the paradox of sex. Recently, several such cases were discovered in social insects. A closer examination of these systems has revealed many amazing facts, including the mixed use of asexual and sexual reproduction for the production of new queens and workers, males that can clone themselves and the routine use of incest without deleterious genetic consequences. In addition, in several species, remarkable cases of asexually reproducing socially parasitic worker lineages have been discovered. The study of these unusual systems promises to provide insight into many basic evolutionary questions, including the maintenance of sex, the expression of sexual conflict and kin conflict and the evolution of cheating in asexual lineages.
Effect of equine-facilitated psychotherapy on posttraumatic stress symptoms in youth with history of maltreatment and abuse

(2002). Brain structures in pediatric maltreatment-related posttraumatic stress disorder: A sociodemographically matched study. (2007). Equine facilitated learning for youths with severe emotional disorders: A quantitative and qualitative study. (2010). Child abuse and autonomic nervous system hyporesponsivity among pschiatrically impaired children.
Distributed Solutions for Energy Efficiency Fairness in Multicell MISO Downlink

This paper aims at guaranteeing the achievable energy efficiency (EE) fairness in a multicell multiuser multiple-input single-output downlink system. The design objective is to maximize the minimum EE among all base stations (BSs) subject to per-BS power constraints. This results in a max-min fractional program and as such is difficult to solve in general. Our goal is to develop decentralized algorithms for the max-min EE problem based on combining the successive convex approximation (SCA) framework and the alternating direction method of multipliers (ADMMs). Specifically, leveraging the SCA principle, we iteratively approximate the nonconvex design problem by a sequence of convex programs for which two decentralized algorithms are then proposed. In the first approach, the convex program obtained at each step of the SCA procedure is solved optimally by allowing the BSs to exchange the required information until the ADMM converges. The convergence of the first method is analytically guaranteed but the amount of backhaul signaling can be noticeable in some realistic settings. To reduce the backhaul overhead, the second method performs an abstract version of the ADMM where only one variables update is carried out. Numerical results are provided to demonstrate the effectiveness of the two proposed decentralized algorithms.
Multi-type maltreatment : relationships between familial characteristics, maltreatment and adjustment of children and adults

Explores the key theme of the nature, extent and impact of experiencing more than one type of maltreatment. Two major studies are reported - parents perceptions of primary school children's family characteristics, experiences of maltreatment and adjustment. The second relies on retrospective reports of adult's childhood experiences. The manner in which family variables influence the relationships between maltreatment and adjustment are explored. Evidence for both mediating and moderating processes in presented.
Rotation-invariant convolutional neural networks for galaxy morphology prediction

Measuring the morphological parameters of galaxies is a key requirement for studying their formation and evolution. Surveys such as the Sloan Digital Sky Survey have resulted in the availability of very large collections of images, which have permitted population-wide analyses of galaxy morphology. Morphological analysis has traditionally been carried out mostly via visual inspection by trained experts, which is time consuming and does not scale to large (≳104) numbers of images. Although attempts have been made to build automated classification systems, these have not been able to achieve the desired level of accuracy. The Galaxy Zoo project successfully applied a crowdsourcing strategy, inviting online users to classify images by answering a series of questions. Unfortunately, even this approach does not scale well enough to keep up with the increasing availability of galaxy images. We present a deep neural network model for galaxy morphology classification which exploits translational and rotational symmetry. It was developed in the context of the Galaxy Challenge, an international competition to build the best model for morphology classification based on annotated images from the Galaxy Zoo project. For images with high agreement among the Galaxy Zoo participants, our model is able to reproduce their consensus with near-perfect accuracy (>99 per cent) for most questions. Confident model predictions are highly accurate, which makes the model suitable for filtering large collections of images and forwarding challenging images to experts for manual annotation. This approach greatly reduces the experts’ workload without affecting accuracy. The application of these algorithms to larger sets of training data will be critical for analysing results from future surveys such as the Large Synoptic Survey Telescope.
Adaptive transmit power control in IEEE 802.11a wireless LANs

Transmit power control (TPC) has been recognized as one of the effective ways to save energy in wireless devices. In this paper, we demonstrate the energy-efficient distributed coordination functions (DCF) operation of IEEE 802.11a wireless LANs (WLANs) via TPC and physical layer (PHY) rate adaptation. The key idea is to enforce an RTS/CTS frame exchange before each data transmission, and then select the most energy-efficient combination of the PHY mode and the transmit power level for the subsequent data frame transmission to save energy. The performance of the proposed scheme is evaluated via simulation in the ns-2 simulator.