Miracle-dz/UniFAR-FTUs huggingface dataset:
Compiler-driven error analysis for designing approximate accelerators

Approximate Computing has emerged as a design paradigm suitable to applications with inherent error resilience. This paradigm aims to reduce the associated computing costs (such as execution time, area, or energy) of exact calculations by reducing the quality of their results. Several approximate arithmetic circuits have been proposed, which can be used to implement hardware blocks such as approximate accelerators. However, to satisfy quality constraints in these accelerators, it is imperative to assess how the errors introduced by approximate circuits propagate through other exact and approximate computations, and finally accumulate at the output. This is, in particular, crucial to enable high-level synthesis of approximate accelerators. This work proposes a compiler-driven error analysis methodology to evaluate the behavior of errors generated from approximate adders in the design of approximate accelerators. We present CEDA, a tool to perform a static analysis of the error propagation. This tool uses #pragma-based annotated C/C++ source code as input. With these annotations, exact additions are replaced by approximate ones during the code analysis to estimate the error at the output. The error estimations produced by our tool are comparable to those obtained through simulations.
Guanidine Alkaloids from the Marine Sponge Monanchora pulchra Show Cytotoxic Properties and Prevent EGF-Induced Neoplastic Transformation in Vitro

Guanidine alkaloids from sponges Monanchora spp. represent diverse bioactive compounds, however, the mechanisms underlying bioactivity are very poorly understood. Here, we report results of studies on cytotoxic action, the ability to inhibit EGF-induced neoplastic transformation, and the effects on MAPK/AP-1 signaling of eight rare guanidine alkaloids, recently isolated from the marine sponge Monanchora pulchra, namely: monanchocidin A (1), monanchocidin B (2), monanchomycalin C (3), ptilomycalin A (4), monanchomycalin B (5), normonanchocidin D (6), urupocidin A (7), and pulchranin A (8). All of the compounds induced cell cycle arrest (apart from 8) and programmed death of cancer cells. Ptilomycalin A-like compounds 1–6 activated JNK1/2 and ERK1/2, following AP-1 activation and caused p53-independent programmed cell death. Compound 7 induced p53-independent cell death without activation of AP-1 or caspase-3/7, and the observed JNK1/2 activation did not contribute to the cytotoxic effect of the compound. Alkaloid 8 induced JNK1/2 (but not ERK1/2) activation leading to p53-independent cell death and strong suppression of AP-1 activity. Alkaloids 1–4, 7, and 8 were able to inhibit the EGF-induced neoplastic transformation of JB6 P+ Cl41 cells. Our results suggest that investigated guanidine marine alkaloids hold potential to eliminate human cancer cells and prevent cancer cell formation and spreading.
Preventing type 2 diabetes among Palestinians: comparing five future policy scenarios

Objective This paper aims to provide estimates of future diabetes prevalence in the West Bank, occupied Palestinian territory (oPt), and to compare five future policy scenarios for diabetes prevention. Design We created and refined a mathematical Markov model that integrates population, obesity and smoking trends to estimate future diabetes prevalence. Model parameters were derived from the literature. Diabetes incidence was estimated using DISMOD software. We developed the model for the Palestinian population based on data available for the period 2000–2010, and validated the model by comparing predicted diabetes prevalence to subsequent actual observed diabetes prevalence rates. Setting West Bank oPt. Results Palestinian diabetes mellitus prevalence estimated by the model (for adults aged 25 or more) was 9.7% in 2000, increasing to 15.3% by 2010. Prevalence in men increased from 9.1% to 16.9% and in women from 10.2% to 13.6%. Comparisons of the model results with the observed prevalence in the Palestinian Family Health Survey showed a close fit. The model forecasts were 20.8% for 2020 and 23.4% for 2030. A 2.8% reduction in diabetes prevalence could be achieved if obesity trends start to decline by 5% in a 5-year period. If obesity prevalence was reduced by 35% in 10 years, as suggested by the WHO, diabetes prevalence might be decreased by 20%. Conclusions The model estimates an increase in the prevalence of diabetes which poses a large challenge to the health system. However, if bold but reasonable action is taken, effective interventions could reduce diabetes prevalence and hence the number of patients with diabetes.
Algorithm for the layout of a piezoelectric element in an elastic medium providing the maximal piezoelectric effect within a specified frequency range

ABSTRACT An algorithm for the layout of a piezoelectric that provides the most efficient performance within a specified range of vibration frequencies is proposed in this paper. This algorithm is based on the consideration of a special parameter within the area of a piezoelectric element’s possible location. This parameter characterizes the superposition of electromechanical coupling coefficients’ for all the natural vibration frequencies included in a specified frequency range. The condition for defining the best option for location of the piezoelectric element in the case of several equivalent positions is specified. The efficiency of the proposed algorithm is shown numerically. The electromechanical coupling coefficients were calculated numerically based on solution to the problem of natural vibrations for electroelastic bodies using a finite element method. The calculations were performed to define the best location for a single piezoelectric element at the surface of a thin-walled shell having a half-cylindrical shape. The results are presented for natural vibration frequencies within the frequency range from 0 up to 1100 Hz. The numerical results were obtained by solving the problem of natural vibrations with a finite element method using the ANSYS software package. Graphical Abstract
The role of secondary cytoreduction in the management of the first relapse in epithelial ovarian cancer.

BACKGROUND The aim of this study was to investigate the benefit of secondary cytoreduction (SCR) in the first relapse in epithelial ovarian cancer and to attempt to define selection criteria for SCR. PATIENTS AND METHODS A retrospective population-based study on recorded information from 789 patients treated at the Norwegian Radium Hospital during 1985-2000 for their initial recurrence. In all, 217 had SCR and 572 were treated with chemotherapy alone. RESULTS Median survival time (MST) was 1.1 years for the chemotherapy group. Complete optimal cytoreduction (COC) was achieved in 35% of all 217 patients, in 49% of the patients operated with debulking intent and in 52% if bowel surgery was done with debulking intent. MST was 4.5 versus 0.7 years for 0 versus>2 cm residual disease, respectively. Residual disease after SCR, treatment-free interval (TFI) and age were found to be prognostic factors for overall survival (OS) in multivariate analysis. Localised tumour was found to be the only significant factor to predict COC. CONCLUSIONS SCR followed by chemotherapy gives a clear survival benefit compared with chemotherapy and should be offered when the tumour is localised. The combination of COC, TFI >24 months and age </=39 years identifies a group of patients with the best OS.
A randomized controlled trial of the effectiveness of a postnatal psychoeducation programme on self-efficacy, social support and postnatal depression among primiparas.

AIM To examine the effectiveness of a postnatal psychoeducation programme in enhancing maternal self-efficacy and social support and reducing postnatal depression among primiparas. BACKGROUND Primiparas experience various challenges during the early postnatal period with low self-efficacy, depression and lack of social support. Support in the form of postnatal educational programmes is needed to improve these outcomes of primiparas. DESIGN A randomized controlled two-group pre-test-post-test design was adopted. METHODS Data were collected from June-December 2012 in a public hospital in Singapore from 122 primiparas, who were randomly assigned to the intervention (n = 61) or control group (n = 61). The intervention group received postnatal psychoeducation programme and routine care while the control group received routine care only. The Maternal Parental Self-Efficacy scale, Perinatal Infant Care Social Support scale and Edinburgh Postnatal Depression Scale were used to measure outcomes of maternal parental self-efficacy, social support and postnatal depression. The mean percentage changes of all three outcome variables from baseline to 6 and 12 weeks postpartum between groups were used when performing repeated measures multivariate analysis of covariance. RESULTS The intervention group had significantly higher scores of maternal parental self-efficacy and social support and lower scores of postnatal depression at 6 and 12 weeks postpartum when compared with the control group. CONCLUSION The postnatal psychoeducation programme was effective in improving maternal outcomes and hence could be introduced as routine care with ongoing evaluation in the postnatal period. Future studies could focus on the effects of this programme on other populations. TRIAL REGISTRATION NO ISRCTN15886353.
Co-rumination, anxiety, and maladaptive cognitive schemas: when friendship can hurt

Background This study investigated maladaptive cognitive schemas as mediators of the relationship between co-rumination and anxiety. Methods Self-report measures of co-rumination, trait cognitive and somatic anxiety, and early maladaptive cognitive schemas were provided to a nonclinical sample of 461 young adults. Mediation of co-rumination and trait somatic and cognitive anxiety by each early maladaptive schema domain was tested using nonparametric, bootstrap-based resampling. Results Significant associations between co-rumination and trait and cognitive anxiety were mediated by schema domains related to Rejection and Disconnection, Overvigilance and Inhibition, and Impaired Autonomy. The association between co-rumination and somatic anxiety was mediated by domains related to Rejection and Disconnection and Impaired Autonomy. Conclusion The results of this study showed that those who engage in co-rumination, potentially resulting in clinical levels of anxiety, might benefit from treatment that focuses on themes of rejection sensitivity and belonging, beliefs about autonomy, and when the anxiety is more cognitive, treatment that focuses on hypercriticalness and emotional inhibition too.
Derivation and implementation of a cone-beam reconstruction algorithm for nonplanar orbits

B.D. Smith (ibid., vol.MI-4, p.15-25, 1985; Opt. Eng., vol.29, p.524-34, 1990) and P. Grangeat (These de doctorat, 1987; Lecture Notes in Mathematics 1497, p.66-97, 1991) derived a cone-beam inversion formula that can be applied when a nonplanar orbit satisfying the completeness condition is used. Although Grangeat's inversion formula is mathematically different from Smith's one, they have similar overall structures to each other. The contribution of the present paper is two-fold. First, based on the derivation of Smith, the authors point out that Grangeat's inversion formula and Smith's one can be conveniently described using a single formula (the Smith-Grangeat inversion formula) that is in the form of space-variant filtering followed by cone-beam back projection. Furthermore, the resulting formula is reformulated for data acquisition systems with a planar detector to obtain a new reconstruction algorithm. Second, the authors make two significant modifications to the new algorithm to reduce artifacts and numerical errors encountered in direct implementation of the new algorithm. As for exactness of the new algorithm, the following fact can be stated. The algorithm based on Grangeat's intermediate function is exact for any complete orbit, whereas that based on Smith's intermediate function should be considered as an approximate inverse excepting the special case where almost every plane in 3D space meets the orbit. The validity of the new algorithm is demonstrated by simulation studies.
Generating Descriptions from Structured Data Using a Bifocal Attention Mechanism and Gated Orthogonalization

In this work, we focus on the task of generating natural language descriptions from a structured table of facts containing fields (such as nationality, occupation, etc) and values (such as Indian, actor, director, etc). One simple choice is to treat the table as a sequence of fields and values and then use a standard seq2seq model for this task. However, such a model is too generic and does not exploit task specific characteristics. For example, while generating descriptions from a table, a human would attend to information at two levels: (i) the fields (macro level) and (ii) the values within the field (micro level). Further, a human would continue attending to a field for a few timesteps till all the information from that field has been rendered and then never return back to this field (because there is nothing left to say about it). To capture this behavior we use (i) a fused bifocal attention mechanism which exploits and combines this micro and macro level information and (ii) a gated orthogonalization mechanism which tries to ensure that a field is remembered for a few time steps and then forgotten. We experiment with a recently released dataset which contains fact tables about people and their corresponding one line biographical descriptions in English. In addition, we also introduce two similar datasets for French and German. Our experiments show that the proposed model gives 21% relative improvement over a recently proposed state of the art method and 10% relative improvement over basic seq2seq models. The code and the datasets developed as a part of this work are publicly available on https://github.com/PrekshaNema25/StructuredData_To_Descriptions
Apolipoprotein E ɛ4, Cognitive Function, and Pain Experience in Down Syndrome: A Pilot Study.

OBJECTIVE The presence of apolipoprotein E (ApoE) ɛ4 allele might be related to higher pain experience due to increased risk for potentially painful physical conditions and cognitive impairment (less efficient coping with pain). This hypothesis is clinically relevant to examine in adults with Down syndrome (DS) because they are at risk for painful physical conditions, their presence of ApoE ε4 is related to cognitive impairment, and their pain experience is unclear. The present pilot study addressed the associations between ApoE genotype, cognition, and pain in DS. METHOD DNA analysis of saliva, neuropsychological tests (assessing memory and executive functioning), and self-reporting pain scales (in rest and after movement) were used with a cross-sectional design in 146 adults with DS (mean age 39.1 years, mild to moderate intellectual disabilities, 46% men, 30% ApoE ɛ4 carrier). RESULTS The difference between ApoE ɛ4 carriers and noncarriers was not statistically significant for cognitive function, pain experience, and prevalence of potentially painful conditions. Among ɛ4 carriers, the presence of potentially painful conditions was associated with worse executive functioning (p = .022, r = .39). CONCLUSIONS The clinical implication of the results is that ApoE ɛ4 in DS may play a role in pain, although the theoretical explanation via associations with pain experience and cognition remains unclear. Further research should include a large sample of adults with DS selected on diagnosed painful conditions to obtain more insight into the possible role of ApoE genotype (and its association with cognition) in the pain experience of this target group.
Diagnosing systemic lupus erythematosus: new-generation immunoassays for measurement of anti-dsDNA antibodies are an effective alternative to the Farr technique and the Crithidia luciliae immunofluorescence test

The aim of this study was to evaluate the diagnostic performance of four new enzyme immunoassays (EIAs) for anti-double-stranded-DNA (anti-dsDNA) antibodies, in comparison with the Farr assay and the Crithidia luciliae immunofluorescence test (CLIFT). To this purpose, sera from four patient groups were collected: 52 sera from patients with systemic lupus erythematosus (SLE); 28 from patients with other connective tissue diseases (CTD); 36 from patients with hepatitis C virus (HCV) infection; and 24 from those with acute viral infection. All sera were tested for anti-dsDNA antibodies by four EIA methods using a different antigenic DNA source [synthetic oligonucleotide (Method A), circular plasmid (Method B), recombinant (Method C), and purified extracted (Method D)], and by CLIFT and Farr assays. The diagnostic sensitivity of the assays was as follows: 84.6% (Method A), 73% (B), 82.7% (C), 84.6% (D), 55.8% (CLIFT), and 78.8% (Farr). Specificity was 82.9% (A), 97.7% (B), 96.5% (C), 94.3% (D), 96.5% (CLIFT), and 90.9% (Farr). From these data, we can conclude that the new-generation EIA methods evaluated in this study have higher sensitivity than the CLIFT and Farr assays and, with the exception of Method A, have specificity similar to the CLIFT and slightly higher than the Farr assay. These findings suggest that EIA tests may replace CLIFT as a screening test and the Farr assay as a specific test, for anti-dsDNA antibody detection.
High Staphylococcus aureus Colonization Prevalence among Patients with Skin and Soft Tissue Infections and Controls in an Urban Emergency Department

ABSTRACT Staphylococcus aureus is a commensal species that can also be a formidable pathogen. In the United States, an epidemic of community-acquired methicillin-resistant Staphylococcus aureus (MRSA) infections has been occurring for the last 15 years. In the context of a study in which we identified patients with skin and soft tissue infections (SSTIs) and randomized them to receive one of two antimicrobial treatment regimens, we assessed S. aureus colonization in the nares, throat, and perianal skin on the day of enrollment and 40 days after therapy. We compared the prevalence of colonization between the SSTI patients and an uninfected control population. A total of 144 subjects and 130 controls, predominantly African American, participated in this study, and 116 returned for a 40-day follow-up visit. Of the SSTI patients, 76% were colonized with S. aureus at enrollment, as were 65% of the controls. Patients were more likely than the controls to be colonized with USA300 MRSA (62/144 [43.1%] versus 11/130 [8.5%], respectively; P < 0.001). The nares were not the most common site of colonization. The colonization prevalence diminished somewhat after antibiotic treatment but remained high. The isolates that colonized the controls were more likely than those in the patients to be methicillin-susceptible S. aureus (MSSA) (74/84 [88.1%] versus 56/106 [52.8%], respectively; P < 0.001). In conclusion, the prevalence of S. aureus colonization among SSTI patients was high and often involved USA300 MRSA. The prevalence diminished somewhat with antimicrobial therapy but remained high at the 40-day follow-up visit. Control subjects were also colonized at a high prevalence but most often with a genetic background not associated with a clinical infection in this study. S. aureus is a commensal species and a pathogen. Plans for decolonization or eradication should take this distinction into account.
Base Station Diversity Propagation Measurements at 73 GHz Millimeter-Wave for 5G Coordinated Multipoint (CoMP) Analysis

This paper describes wideband (1 GHz) base station diversity and coordinated multipoint (CoMP)-style large-scale measurements at 73 GHz in an urban microcell open square scenario in downtown Brooklyn, New York on the NYU campus. The measurements consisted of ten random receiver locations at pedestrian level (1.4 meters) and ten random transmitter locations at lamppost level (4.0 meters) that provided 36 individual transmitter-receiver (TX-RX) combinations. For each of the 36 radio links, extensive directional measurements were made to give insights into small-cell base station diversity at millimeter-wave (mmWave) bands. High-gain steerable horn antennas with 7º and 15º half-power beamwidths (HPBW) were used at the transmitter (TX) and receiver (RX), respectively. For each TX-RX combination, the TX antenna was scanned over a 120º sector and the RX antenna was scanned over the entire azimuth plane at the strongest RX elevation plane and two other elevation planes on both sides of the strongest elevation angle, separated by the 15º HPBW. Directional and omnidirectional path loss models were derived and match well with the literature. Signal reception probabilities derived from the measurements for one to five base stations that served a single RX location show significant coverage improvement over all potential beamformed RX antenna pointing angles. CDFs for nearest neighbor and Best-N omnidirectional path loss and cell outage probabilities for directional antennas provide insights into coverage and interference for future mmWave small-cells that will exploit macro-diversity and CoMP.
HapticSerpent: A Wearable Haptic Feedback Robot for VR

Haptic feedback is an important part of virtual reality (VR), where it can increase the immersion and enjoyment. Within VR, research literature and products are mainly limited to vibrotactile feedback for the torso. We believe that additional types of haptic feedback around other areas of the body could potentially yield interesting VR experiences. Thus, we present HapticSerpent, which is a waist-worn robot capable of various haptic feedback on the torso, neck, face, arms and hands. We present our implementation specifications, followed by an initial evaluation to measure the distinguishability of taps applied to the torso. Also, we surveyed the acceptability of receiving feedback in different locations on the body. Participants noted an overall higher accuracy on the upper and sides of the torso and they generally disfavored haptic feedback in sensitive areas due to potential harm. Lastly, we discuss various research opportunities and challenges and present our future direction.
Co-propagating distributed Raman amplifier utilizing incoherent pumping

We have developed a semiconductor optical amplifier (SOA) based incoherent light source for a co-propagating distributed Raman amplifier. By utilizing the incoherent light source as a 1st-order pump of the Raman amplifier, we have experimentally verified the reduction of RIN transfer regardless of the presence of simultaneous amplification by 2nd-order coherent pumps. In addition, improved Q-factor has been demonstrated by 22.5 Gbaud polarization-division multiplexing 16 quadrature amplitude modulation (PDM-16QAM) transmission experiment over 2720 km in a re-circulating fiber loop. From subsequent experimental study, we have redesigned wavelength shifted 1st-order incoherent pump and measured at Raman gains in L-band wavelength.
Fast multi-layer critical area computation

Based on the corner-stitching data structure, a geometrical approach to compute the critical area of a layout is presented. The run time of the proposed approach is linear to the number of patterns in a layout. Multilayer effect is taken into account so that the critical area computed for each mask layer is more accurate. The experimental results show that the method is promising for layout sensitivity analysis, yield estimation and realistic fault analysis.