Miracle-dz/UniFAR-FTUs huggingface dataset:
A novel method for creating working space during endoscopic thyroidectomy via bilateral areolar approach.

BACKGROUND Endoscopic thyroidectomy (ET) can be performed through the bilateral areolar approach (BAA). A working space (WS) is typically created on the surface of the pectoral fascia in the chest wall and in the subplatysmal space in the neck. There are several limitations of using this WS. The aim of this study was to establish a new WS for ET. SUBJECTS AND METHODS A retrospective review was performed on 85 patients with benign thyroid nodules who had undergone ET through a BAA. A WS was created between the anterior and poster layers of the superficial pectoral fascia (SPF) in the chest and underneath the deep layer of the investing layer (IL) in the neck. RESULTS The time for creating the WS was 7.2 ± 2.1 (range, 5-12) minutes. No hemorrhage occurred during the procedure. Fat liquefaction occurred in 2 patients. Edema of the neck skin flap presented as lack of a suprasternal notch. No skin numbness occurred. No patient required postoperative pain medication. All patients were extremely satisfied with the cosmetic results. CONCLUSIONS This new method of establishing a WS between the two layers of the SPF and underneath the IL is simple and fast, provides good exposure, yields less postoperative pain, and has a lower risk of skin burn.
Bayesian Image Restoration under Poisson Noise and Log-concave Prior

In recent years, much research has been devoted to the restoration of Poissonian images using optimization-based methods. On the other hand, the derivation of efficient and general fully Bayesian approaches is still an active area of research and especially if standard regularization functions are used, e.g. the total variation (TV) norm. This paper proposes to use the recent split-and-augmented Gibbs sampler (SPA) to sample efficiently from an approximation of the initial target distribution when log-concave prior distributions are used. SPA embeds proximal Markov chain Monte Carlo (MCMC) algorithms to sample from possibly non-smooth log-concave full conditionals. The benefit of the proposed approach is illustrated on several experiments including different regularizers, intensity levels and with both analysis and synthesis approaches.
Adaptive Operator Selection in NSGA-III

Many-objective optimization (four or more objectives) presents many challenges to be considered, highlighting the need to create better algorithms prepared to deal efficiently with the increasing number of objectives. One such challenge is to determine the most efficient operator or combination of operators to be used during the optimization. In order to deal with this challenge, we propose the use of adaptive operator selection mechanisms in many-objective optimization algorithms. Two adaptive operator selection mechanisms, Adaptive Pursuit (AP) and Probability Matching (PM), are incorporated into the NSGA-III framework (a recently proposed, state-of-the-art algorithm to solve many-objective problems) to autonomously select the most suitable operator while solving a many-objective problem, according to the previous performance of each operator. The proposed algorithms, NSGA-IIIAP and NSGA-IIIPM, are tested in four different multi-objective problems from the DTLZ test suite with 3 up to 20 objectives. Statistical tests were performed to infer the significance of the results. The hypothesis that adaptive ways to select the operator to be applied during each stage of the evolutionary process is an effective way to improve the performance of the NSGA-III framework is corroborated by our results.
The optimal n-body method for stability studies of galaxies

The stability of a galaxy model is most easily assessed through N-body simulation. Particle-mesh codes have been widely used for this purpose, since they enable the largest numbers of particles to be employed. We show that the functional expansion technique, originally proposed by Clutton-Brock for other simulation problems, is in fact superior for stability work. For simulations of linear evolution it is not much slower than grid methods using the same number of particles, and reproduces analytical results with much greater accuracy. This success rests on its ability to represent global modes with a modest number of basis functions; grid methods may be more effective for other applications, however. Our conclusions are based on implementations of functional expansion and grid algorithms for disk galaxies.
Efficacy of Hilbert and Wavelet Transforms for Time-Frequency Analysis

Two independently emerging time-frequency transformations in Civil Engineering, namely, the wavelet transform and empirical mode decomposition with Hilbert transform (EMD+HT) , are discussed in this study. Their application to a variety of nonstationary and nonlinear signals has achieved mixed results, with some comparative studies casting significant doubt on the wavelet’s suitability for such analyses. Therefore, this study shall revisit a number of applications of EMD+HT in the published literature, offering a different perspective to these commentaries and highlighting situations where the two approaches perform comparably and others where one offers an advantage. As this study demonstrates, much of the differing performance previously observed is attributable to EMD+HT representing nonlinear characteristics solely through the instantaneous frequency, with the wavelet relying on both this measure and the instantaneous bandwidth. Further, the resolutions utilized by the two approaches present a seconda.
Fibroblast Growth Factor Receptors (FGFRs) in Human Sperm: Expression, Functionality and Involvement in Motility Regulation

Fibroblast growth factors receptors (FGFRs) have been widely characterized in somatic cells, but there is scarce evidence of their expression and function in mammalian gametes. The objective of the present study was to evaluate the expression of FGFRs in human male germ cells, to determine sperm FGFR activation by the FGF2 ligand and their participation in the regulation of sperm motility. The expression of FGFR1, 2, 3 and 4 mRNAs and proteins in human testis and localization of these receptors in germ cells of the seminiferous epithelium was demonstrated. In ejaculated sperm, FGFRs were localized to the acrosomal region and flagellum. Sperm exposure to FGF2 caused an increase in flagellar FGFR phosphorylation and activation of extracellular signal-regulated kinase (ERK) and protein kinase B (PKB or Akt) signaling pathways. Incubation with FGF2 led to a significant increase in the percentage of total and progressive sperm motility, as well as in sperm kinematics. All responses were prevented by sperm preincubation with BGJ398, a specific inhibitor of FGFR tyrosine kinase activity. In addition to confirming the expression of FGFRs in germ cells of the human testis, our study describes for the first time the presence, localization and functionality of human sperm FGFRs, and provides evidence of the beneficial effect of FGF2 upon sperm motility.
PAC Identification of a Bandit Arm Relative to a Reward Quantile

We propose a PAC formulation for identifying an arm in an n-armed bandit whose mean is within a fixed tolerance of the m-th highest mean. This setup generalises a previous formulation with m = 1, and differs from yet another one which requires m such arms to be identified. The key implication of our proposed approach is the ability to derive upper bounds on the sample complexity that depend on n/m in place of n. Consequently, even when the number of arms is infinite, we only need a finite number of samples to identify an arm that compares favourably with a fixed reward quantile. This facility makes our approach attractive to applications such as drug discovery, wherein the number of arms (molecular configurations) may run into a few thousands. We present sampling algorithms for both the finite- and infinite-armed cases, and validate their efficiency through theoretical and experimental analysis.We also present a lower bound on the worst case sample complexity of PAC algorithms for our problem, which matches our upper bound up to a logarithmic factor.
Sub-ontologies and ontology views: a theoretical perspective

The success of the Semantic Web (SW) relies heavily on formulation and interoperability of well-defined ontologies and their utilisation. Thus, in this context, it is interesting to investigate concepts like ontology view specification, construction and extraction. Here, in this paper, we address one such issue: ontology views. The proposed ontology view mechanism is a Layered View Model (LVM) and is specified and defined using conceptual and logical level semantics, as opposed to a query language. Our aim here is to provide a detailed theoretical foundation for LVM for ontologies. Also, our proposed concepts are illustrated using an industrial case-study example.
Nurses' use of non-pharmacological methods in children's postoperative pain management: educational intervention study.

AIM This paper is a report of study of the impact of an educational intervention in pain management on nurses' self-reported use of non-pharmacological methods for children's postoperative pain relief and their perceptions of barriers that limited their use of these methods. BACKGROUND Non-pharmacological methods have been shown to be effective in relieving pain; however, many barriers, including lack of knowledge, limit nurses' use of these methods. Pain education is a promising strategy for changing nursing practice, but only a few authors have examined the effectiveness of educational interventions for nurses to help relieve children's postoperative pain. METHODS A quasi-experimental one-group pre- and post-test design was used. Questionnaire surveys were conducted with a convenience sample of 108 Registered Nurses in two public hospitals in Singapore in 2008. RESULTS Statistically significant increases were found in nurses' self-reported use of imagery, positive reinforcement, thermal regulation, massage and positioning in the postintervention survey. Before the intervention, these methods were less frequently used compared to other methods. Heavy workload/lack of time and the child's inability to cooperate were the most commonly reported barriers at pre- and post-test. CONCLUSION The educational intervention had a positive effect on nurses' use of several non-pharmacological methods. Regular dissemination of updated information to nurses on these pain management methods is recommended to maintain the positive changes. Nevertheless, education alone was not sufficient to optimize nurses' use of these methods, as various barriers limited their practice.
Characteristics of a newly developed dentomaxillofacial X-ray cone beam CT scanner (CB MercuRay): system configuration and physical properties.

OBJECTIVE The purpose of this paper is to present the system configuration and physical properties of a new dentomaxillofacial X-ray cone beam CT system (CB MercuRay) being developed. METHODS The system consists of an image intensifier and a cone beam X-ray source. There are two different models of this system, each with a different size image intensifier, 9" or 12". Each system has three field of view (FOV) modes. The 12" system has facial (F), panoramic (P) and implant (I) FOV modes. The 9" system has P, I and dental (D) modes. Images produced by these systems consist of 512 x 512 x 512 isotropic voxels. Physical properties such as resolution, noise and distortion of the images were evaluated in this study. Modulation transfer function (MTF) was measured using Boone's method. Image noise was measured as the standard deviation of the CT value in water. Circularity of the axial images yielded by the two models was measured using an 8 mm diameter acrylic pipe phantom. RESULTS The resolving power at a MTF of 0.1 in the D mode was over 2.0 lp mm(-1), suggesting that this system yields images of high resolution. The standard deviation of the CT value in water was approximately 80, which is thought to be greater than that of conventional CT. The circularity of images of the pipe phantom was 99% of the ideal value. CONCLUSION This study shows that our newly developed cone beam CT system produces high resolution three-dimensional volumetric images that will be useful for the examination of dentomaxillofacial disorders.
Salivary Cortisol Level, Salivary Flow Rate, and Masticatory Muscle Activity in Response to Acute Mental Stress: A Comparison between Aged and Young Women

Background: Age-related effects on physiological stress reactions regarding changes in salivary cortisol concentration, saliva flow rate, and masticatory muscle activity, as well as the corresponding perceived mental stress and performance in response to acute stressors, have not yet been fully described. Objective: Thus, the aim of this study was to assess the age-related variations in these variables in response to minor acute and naturalistic stressors in terms of computer tasks. Methods: 13 aged (60–70 years old) and 13 young (20–30 years old) women with frequent practice and long experience with computer use were recruited by personal contact and flyers. The subjects were healthy and had full dental arches and no orofacial pain. The computer tasks were randomized and comprised a mentally demanding, modified Stroop colour-word test (CWT) and a less demanding reference test, both with a duration of 20 min and with equal physical demand. Visual analogue scales for global assessment of mental stress and perceived task difficulty and performance, measurements of saliva flow rate and cortisol concentration (unstimulated whole saliva), as well as surface electromyography of the temporalis and masseter muscles were used for assessment, and Spearman correlation analysis and Anova with repeated measures were used for statistical evaluation. Results: The perceived task-related stress and task difficulty were significantly higher and the personal satisfaction with the task performance significantly poorer in the aged women. The cortisol concentration, indicating the stress level, showed a small, but significant increase in response to the tasks. Also the saliva flow rate increased. This response was most pronounced in the aged and during the CWT. The average electromyogram varied significantly between age groups and tasks, with higher levels and shorter relative periods with gaps in the aged women and in the CWT. In addition, the peak activity of the jaw elevator muscles at mouse clicking was significantly elevated as a form of co-activation or attention-related activity. Conclusions: The study showed marked differences in the response to mental demands in aged as compared with young women. The mental stress, reflected by increases of salivary cortisol concentration, saliva flow rate, visual analogue scale ratings, and activity level of the jaw elevator muscles, was more pronounced in the aged women in response to the computer tasks.
Mitochondrial and Cytoplasmic ROS Have Opposing Effects on Lifespan

Reactive oxygen species (ROS) are highly reactive, oxygen-containing molecules that can cause molecular damage within the cell. While the accumulation of ROS-mediated damage is widely believed to be one of the main causes of aging, ROS also act in signaling pathways. Recent work has demonstrated that increasing levels of superoxide, one form of ROS, through treatment with paraquat, results in increased lifespan. Interestingly, treatment with paraquat robustly increases the already long lifespan of the clk-1 mitochondrial mutant, but not other long-lived mitochondrial mutants such as isp-1 or nuo-6. To genetically dissect the subcellular compartment in which elevated ROS act to increase lifespan, we deleted individual superoxide dismutase (sod) genes in clk-1 mutants, which are sensitized to ROS. We find that only deletion of the primary mitochondrial sod gene, sod-2 results in increased lifespan in clk-1 worms. In contrast, deletion of either of the two cytoplasmic sod genes, sod-1 or sod-5, significantly decreases the lifespan of clk-1 worms. Further, we show that increasing mitochondrial superoxide levels through deletion of sod-2 or treatment with paraquat can still increase lifespan in clk-1;sod-1 double mutants, which live shorter than clk-1 worms. The fact that mitochondrial superoxide can increase lifespan in worms with a detrimental level of cytoplasmic superoxide demonstrates that ROS have a compartment specific effect on lifespan – elevated ROS in the mitochondria acts to increase lifespan, while elevated ROS in the cytoplasm decreases lifespan. This work also suggests that both ROS-dependent and ROS-independent mechanisms contribute to the longevity of clk-1 worms.
No Evidence for Generalized Increased Postoperative Responsiveness to Pain: A Combined Behavioral and Serial Functional Magnetic Resonance Imaging Study

BACKGROUND: Although it is generally accepted that increased pain responsiveness and central sensitization develop after major tissue injury, this claim has not been tested using brain imaging methods in a clinical pain setting. We tested this hypothesis using a postoperative pain model, in conjunction with serial functional magnetic resonance imaging (fMRI). METHODS: We studied brain and subjective pain responses to innocuous and noxious heat in seven patients before and after total knee arthroplasty. Noxious and innocuous thermal stimuli were applied to the upper leg, proximal to the surgical area and to the lower forearm, a site remote from the surgical area. A group of eight age- and sex-matched control subjects underwent the same two-test procedure except that they were not submitted to an orthopedic surgical intervention. RESULTS: Subjective pain and brain responses to innocuous and noxious stimulation were not increased postoperatively. Actually, responses in primary and secondary somatosensory cortex for stimulation of the operated leg were significantly smaller after surgery. Brain responses in the control group did not differ significantly across the two sessions. CONCLUSION: These data argue against the development of an overall increased pain responsiveness after a major surgical trauma. The data are in contrast with results from animal studies and from brain imaging studies using surrogate models of clinical pain, which have shown increased central responsiveness in the area around the insult, thereby calling into question the clinical implications of acute postinjury sensitization.
Improving images of fluorescent cell labeling by background signal subtraction

The uptake and selective accumulation of fluorescent labels and drugs into organelles of cultured cells currently are widely investigated in biomedical research. In such studies, co-localization procedures are frequently used to identify the accumulation sites of compounds with biological activity. A drawback with fluorescent labeling is the autofluorescence of some cell organelles, which can hinder the precise assessment of co-localization. We report here labeling of the Golgi apparatus of A-549 cells using the photosensitizer zinc(II)-phthalocyanine (ZnPc) and co-localization with the Golgi probe NBD C6-ceramide. The blue autofluorescence signal of mitochondria can be subtracted easily from the original picture by image processing, after which the co-localization of the isolated red ZnPc signal with the green signal from the Golgi probe is considerably improved.
Evaluation of Tom Fertility as Affected by Dietary Fatty Acid Composition

The objective of two studies was to manipulate the essential fatty acid content of turkey semen by enhancing the dietary levels of either n-3 polyunsaturated fatty acids (PUFA) or n-6 PUFA and determine the effect on fertility. In 1999 (Trial 1), and again in 2000 (Trial 2), Large White tom turkeys, 37 weeks of age, were fed one of three diets substituted with chicken fat, soybean oil, or menhaden fish oil. Chicken fat provided the industry’s standard ratio of n-6 to n-3, soybean oil provided a greater ratio of n-6 to n-3, and fish oil provided a lower ratio of n-6 to n-3. Contemporary hens were inseminated weekly with semen collected from each group of toms. The effects of dietary lipids on tom body weights, fertility, motility, perivitelline layer sperm penetration percent, and live vs. dead sperm were analyzed. Whereas body weight increased linearly from 31 to 56 weeks of age (WOA), there was no effect of dietary treatment. As measured by the Accudenz® procedure, there were differences in sperm motility due to dietary treatment during 48 and 51 WOA during Trial 1. During Trial 2, sperm motility differences were observed at 53 WOA with the soybean oil-treated toms having the largest absorbance reading and the chicken fat-treated toms having the largest absorbance reading during 56 WOA. The live vs. dead sperm cells during Trial 1 revealed differences among the toms prior to treatment and post treatment. No dietary effects on percent live vs. dead sperm cells were observed during Trial 2. Once per mo, eggs were collected for a one-week period to analyze for sperm penetration of the perivitelline layer. In Trial 1, sperm from toms fed chicken fat produced more penetrations (holes) during 36, 48, and 52 WOA. In Trial 2, sperm penetration values were lower for toms fed fish oil during 42, 47, and 51 WOA. Whereas there were significant differences in fertility, hatch of total eggs, and hatch of fertile eggs among treatments in Trial 1, a bacterial contamination on the farm during weeks seven through fourteen may have contributed to these findings. No significant differences due to treatment were found in these parameters during the second study. The fatty acid analysis of spermatozoa collected at the conclusion of Trial 2 revealed significant differences in total n-3 and total n-6 content, leading to significant differences in the ratio of total n-6 to total n-3. The mixed results indicated the fertilizing ability of domesticated turkey spermatozoa may not be affected by the n-6 to n-3 ratio in the diet of the tom.
The Uniform Data Set (UDS): Clinical and Cognitive Variables and Descriptive Data From Alzheimer Disease Centers

A Clinical Task Force, composed of clinical leaders from Alzheimer's Disease Centers (ADC), was convened by the National Institute on Aging to develop a uniform set of assessment procedures to characterize individuals with mild Alzheimer disease and mild cognitive impairment in comparison with nondemented aging. The resulting Uniform Data Set (UDS) defines a common set of clinical observations to be collected longitudinally on ADC participants in accordance with standard methods. The UDS was implemented at all ADCs on September 1, 2005. Data obtained with the UDS are submitted to the National Alzheimer's Coordinating Center and represent a unique and valuable source of data to support and stimulate collaborative research.
System identification of hunchback protein patterning in early drosophila embryogenesis

Early patterning in the Drosophila melanogaster embryo occurs through a complicated network of interactions involving transcription factor proteins and the mRNA of their target genes. One such system is the pattern of hunchback mRNA and its regulation by Bicoid and Krüppel proteins. This system is well-studied, but there is disagreement amongst biologists on how exactly hunchback expression is regulated. We attempt here to provide evidence to distinguish between two models in contention, through system identification. Our general approach is to do nonlinear regression on a parametric, nonlinear partial differential equation model which incorporates transcription, diffusion, and degradation. We perform the regression, analyze the results and then interpret the results in the biological context. We also compare our results to previous work on this system.