Miracle-dz/UniFAR-FTUs huggingface dataset:
History of allergies among adults with glioma and controls

The causes of most adult gliomas are essentially unknown. Previous studies have indicated associations between immune system factors and the incidence of adult glioma, specifically that those individuals with certain allergic conditions may have decreased risk of glioma. We obtained detailed allergy histories for 405 adults newly diagnosed with glioma in the San Francisco Bay Area from 1997–1999 and 402 age‐gender‐ethnicity frequency‐matched population‐based controls. Seventy‐nine percent of eligible cases or their proxies and 74% of eligible controls completed in‐person interviews about allergies, age at onset, frequency, duration and severity. Overall, cases were less likely than controls to report any allergy (72% vs. 85%; odds ratio [OR] = 0.5 [0.3–0.7]); for self‐reported cases (n = 269), OR = 0.7 (0.4–0.97) and for proxy‐reported cases, OR = 0.3 (0.2–0.5). Pollen, dairy and nut allergies were significantly less common in cases than controls and most other allergens had odds ratios of less than one. There were no apparent trends with numbers of symptoms, route of exposure of allergen or reported severity of allergy, but there was a significant dose‐response with increasing numbers of allergens (p < 0.0001 for linear trend among all cases vs. controls and p = 0.02 among self‐reported cases only vs. controls). Although our work displays strong and consistent associations, future efforts must attempt to establish whether an immune system typified by proclivity to allergies, or an immunologic consequence of the allergies themselves, might be capable of preventing nascent brain tumors. The dominance of humoral immunity in the central nervous system is consistent with either of these models. Alternatively, common genetic or environmental causes for allergies and gliomagenesis may mediate or confound these observed inverse risks for allergies and gliomas, or other explanations may exist. Future work might reveal an important role for immunologic factors in gliomagenesis and potential preventative and/or therapeutic modalities. © 2002 Wiley‐Liss, Inc.
A shared control method for obstacle avoidance with mobile robots and its interaction with communication delay

Teleoperation allows human operators to safely extend themselves to remote environments that are typically difficult or dangerous to access. The remote environments are often unstructured (i.e. not having clear roads or paths to follow) and only accessible by wireless communication (introducing factors such as degraded signals and communication delay). Teleoperated driving under these conditions can result in slow operation speeds and unintended collisions with obstacles. Automating portions of the teleoperation task can help mitigate some of the negative effects of wireless communication. Shared control is used to combine inputs from the human teleoperator and automation. This work presents a new model predictive control based shared control method. We introduce a new representation for obstacle free regions that works well with unstructured robot environments and allows for an model predictive control problem formulation that can be solved rapidly. The shared control method is implemented in a robot simulator and tested with human subjects. Two user studies involving a search task with a mobile robot evaluate the effectiveness of the shared control method and explore its interaction with factors such as communication delay and input interface style. Communication delay is found to have the largest magnitude effect on performance and safety measures. Results demonstrate that the shared control method can improve both performance and safety when delays are present.
Tanzawaic Acids, a Chemically Novel Set of Bacterial Conjugation Inhibitors

Bacterial conjugation is the main mechanism for the dissemination of multiple antibiotic resistance in human pathogens. This dissemination could be controlled by molecules that interfere with the conjugation process. A search for conjugation inhibitors among a collection of 1,632 natural compounds, identified tanzawaic acids A and B as best hits. They specially inhibited IncW and IncFII conjugative systems, including plasmids mobilized by them. Plasmids belonging to IncFI, IncI, IncL/M, IncX and IncH incompatibility groups were targeted to a lesser extent, whereas IncN and IncP plasmids were unaffected. Tanzawaic acids showed reduced toxicity in bacterial, fungal or human cells, when compared to synthetic conjugation inhibitors, opening the possibility of their deployment in complex environments, including natural settings relevant for antibiotic resistance dissemination.
Preconditioning protects ischemic rabbit heart by protein kinase C activation.

Myocardial protection in the rabbit induced by ischemic preconditioning is thought to be adenosine receptor linked, but the signaling pathway responsible for the protection has yet to be identified. This study tests whether protein kinase C could be involved. Either of two inhibitors of protein kinase C, staurosporine (50 micrograms/kg) or polymyxin B (24 mg/kg), were administered to rabbits subjected to 30 min regional myocardial ischemia followed by 180 min reperfusion. Half of the rabbits were preconditioned while the other half served as nonpreconditioned controls. Nonpreconditioned hearts without drug or treated with staurosporine or polymyxin B resulted in 37.8 +/- 3.1, 40.5 +/- 2.8, and 42.0 +/- 7.0% infarction of the risk zone, respectively. Preconditioning limited infarct size to 7.3 +/- 2.7%. Both inhibitors blocked protection in preconditioned hearts with 36.2 +/- 2.7 and 40.9 +/- 2.5% of the risk zone infarcted, respectively. Activation of protein kinase C with 4 beta-phorbol 12-myristate 13-acetate (PMA) or with 1-oleyl-2-acetyl glycerol (OAG) mimicked preconditioning in buffer-perfused hearts. PMA (0.01 nmol/min) or OAG (10 nmol/min) for 5 min was followed by 10 min of washout. Infarct size after 30 min regional ischemia was limited in the PMA and OAG groups (6.4 +/- 1.4 and 11.7 +/- 3.3 vs. 28.0 +/- 4.5% in untreated controls) and was equipotent with ischemic preconditioning (11.8 +/- 2.2%). Polymyxin B also blocked protection from ischemic preconditioning in the isolated heart (33.0 +/- 5.0%). (ABSTRACT TRUNCATED AT 250 WORDS)
Solution NMR structure of the 30S ribosomal protein S28E from Pyrococcus horikoshii

We report NMR assignments and solution structure of the 71‐residue 30S ribosomal protein S28E from the archaean Pyrococcus horikoshii, target JR19 of the Northeast Structural Genomics Consortium. The structure, determined rapidly with the aid of automated backbone resonance assignment (AutoAssign) and automated structure determination (AutoStructure) software, is characterized by a four‐stranded β‐sheet with a classic Greek‐key topology and an oligonucleotide/oligosaccharide β‐barrel (OB) fold. The electrostatic surface of S28E exhibits positive and negative patches on opposite sides, the former constituting a putative binding site for RNA. The 13 C‐terminal residues of the protein contain a consensus sequence motif constituting the signature of the S28E protein family. Surprisingly, this C‐terminal segment is unstructured in solution.
Droplet merging in a straight microchannel using droplet size or viscosity difference

In the present study, a novel droplet-merging technique is proposed, which enables two nanoliter or picoliter droplets to merge in a straight microchannel with high precision. Two dispersed phase fluids are supplied respectively from two side channels in a certain range of flow rates to generate droplets of different sizes or different viscosities in a regularly alternating mode at a cross-channel intersection prior to the straight microchannel, in such a manner that the droplets are spontaneously synchronized by themselves due to the competition of the two interfaces formed at the cross-channel intersection. Then they are autogeneously merged in the downstream straight microchannel with or without a sudden expansion of the cross section, due to their velocity difference which is induced as they are transported aboard the continuous phase fluid. This droplet-merging method has no desynchronization or secondary-merging problems. Thus, it can be applied efficiently to mixing or encapsulating one target sample with another material for the purposes of nanoparticle synthesis, hydrogel-bead production, cell transplantation and so forth.
Validity and Stability of the Decisional Balance for Sun Protection Inventory

The 8-item Decisional Balance for sun protection inventory (SunDB) assesses the relative importance of the perceived advantages (Pros) and disadvantages (Cons) of sun protective behaviors. This study examined the psychometric properties of the SunDB measure, including invariance of the measurement model, in a population-based sample of N = 1336 adults. Confirmatory factor analyses supported the theoretically based 2-factor (Pros, Cons) model, with high internal consistencies for each subscale (α ≥ .70). Multiple-sample CFA established that this factor pattern was invariant across multiple population subgroups, including gender, racial identity, age, education level, and stage of change subgroups. Multivariate analysis by stage of change replicated expected patterns for SunDB (Pros η 2 = .15, Cons η 2 = .02). These results demonstrate the internal and external validity and measurement stability of the SunDB instrument in adults, supporting its use in research and intervention.
Electrophysiological Mechanisms of Minoxidil Sulfate-Induced Vasodilation of Rabbit Portal Vein

The electrophysiological and mechanical properties of the vasodilator minoxidil sulfate (MNXS) were examined in isolated smooth muscle cells and strips from rabbit portal vein. At micromolar concentrations, MNXS inhibited norepinephrine (0.1–1.0 μM) -induced contractionsin isolated muscle strips. In isolated cells, norepinephrine caused a dose-dependentdepolarization of the resting membrane potential, which was significantly attenuated by MNXS(5 μM); MNXS alone caused a hyperpolarization of the membrane potential. This hyperpolarizationwas insensitive to Na+-K+ pump blockade by ouabain, but was inhibited by the K+ channel antagonist, tetraethylammonium (20 mM). In voltage-clamp experiments, a resting(background) conductance associated with the resting membrane potential was identified. Thisconductance, which previously has been shown to be reduced by Ba2+ as well as tetraethylammonium, was increased by MNXS (2 μM). In additional experiments, whole-cell L-type Ca2+ currents were inhibited by micromolar concentrations of MNXS. These experiments show thatconcentrations of MNXS that inhibit norepinephrine-induced contractions promote K+ conductanceand inhibit Ca2+ entry through voltage-dependent Ca2+ channels in vascular smoothmuscle cells. These electrophysiological effects of MNXS may be responsible for the vasorelaxanteffects of the drug observed in vitro and in vivo.
Spatial and temporal variation in trace elemental fingerprints of mytilid mussel shells: A precursor to invertebrate larval tracking

Elements incorporated into developing hard parts of planktonic larvae record the environmental conditions experienced during growth. These chemical signatures, termed elemental fingerprints, potentially allow for reconstruction of locations of larvae. Here, we have demonstrated for the first time the feasibility of this approach for bivalve shells. We have determined the spatial scale over which we are able to discriminate chemical signatures in mussels in southern California and characterized the temporal stability of these signals. Early settlers of Mytilus californianus and Mytilus galloprovincialis were collected from eight sites in southern California. Shells were analyzed for nine isotopes using laser ablation‐inductively coupled plasma‐mass spectrometry (LA‐ICP‐MS). We discriminated among mussels collected in two bays and the open coast using Mn, Pb, and Ba shell concentrations. Shell concentrations of Pb and Sr were sufficiently different to discriminate between mussels from the northern and southern regions of the open coast, each representing approximately 20 km of coastline. These signals were relatively stable on monthly and weekly time scales. These results indicate that trace elemental fingerprinting of shell material is a promising technique to track bivalve larvae moving between bays and the open coast or over along‐shore scales on the order of 20 km. Identification of spatial variation in elemental fingerprints that is stable over time represents a crucial step in enhancing our ability to understand larval transport and population connectivity in invertebrates.
Content-Aware Point of Interest Recommendation on Location-Based Social Networks

The rapid urban expansion has greatly extended the physical boundary of users' living area and developed a large number of POIs (points of interest). POI recommendation is a task that facilitates users' urban exploration and helps them filter uninteresting POIs for decision making. While existing work of POI recommendation on location-based social networks (LBSNs) discovers the spatial, temporal, and social patterns of user check-in behavior, the use of content information has not been systematically studied. The various types of content information available on LBSNs could be related to different aspects of a user's check-in action, providing a unique opportunity for POI recommendation. In this work, we study the content information on LBSNs w.r. t. POI properties, user interests, and sentiment indications. We model the three types of information under a unified POI recommendation framework with the consideration of their relationship to check-in actions. The experimental results exhibit the significance of content information in explaining user behavior, and demonstrate its power to improve POI recommendation performance on LBSNs.
Delayed diagnosis of ankylosing spondylitis in a Japanese population

Abstract Objectives: This study was conducted to evaluate the period from symptom onset to diagnosis of ankylosing spondylitis (AS) in Japanese patients and to examine possible reasons for delayed diagnosis. Methods: Seventy-two consecutive patients with AS were studied. Diagnostic delay was defined as the gap between the first spondyloarthropathic symptom and diagnosis of AS according to the modified New York criteria. Results: The mean patient ages at disease onset and diagnosis were 25.6 ± 11.3 and 33.3 ± 13.2 years old, respectively, resulting in diagnostic delay of 6.7 years. The number of medical institutions to which patients were referred before diagnosis was 2.4, and orthopedic surgeons were most commonly visited (62%). Non-specific low back pain or lumbar spondylitis (33%) and degenerative arthritis (28%) were the primary diagnoses preceding that of AS. Absence of articular symptoms significantly correlated with diagnostic delay. The patients with disease onset on year 2000 or later had significantly shorter periods until diagnosis than those before 2000 (3.6 vs. 7.5 years). Conclusions: The present study showed a marked diagnostic delay among Japanese patients with AS. Although it has been improved, continuing medical education focusing on inflammatory back pain in adolescent is required for early diagnosis of AS.
Sex-Related Differences of Lipid Metabolism Induced by Triptolide: The Possible Role of the LXRα/SREBP-1 Signaling Pathway

Triptolide, a diterpenoid isolated from the plant Tripterygium wilfordii Hook. f. , exerts a unique bioactive spectrum of anti-inflammatory and anticancer activities. However, triptolide’s clinical applications are limited due to its severe toxicities. Fatty liver toxicity occurs in response to triptolide, and this toxic response significantly differs between males and females. This report investigated the pathogenesis underlying the sex-related differences in the dyslipidosis induced by triptolide in rats. Wistar rats were administered 0, 150, 300, or 450 μg triptolide/kg/day by gavage for 28 days. Ultrastructural examination revealed that more lipid droplets were present in female triptolide-treated rats than in male triptolide-treated rats. Furthermore, liver triglyceride, total bile acid and free fatty acid levels were significantly increased in female rats in the 300 and 450 μg/kg dose groups. The expression of liver X receptor α (LXRα) and its target genes, cholesterol 7α-hydroxylase (CYP7A1) and Sterol regulatory element-binding transcription factor 1(SREBP-1), increased following triptolide treatment in both male and female rats; however, the female rats were more sensitive to triptolide than the male rats. In addition, the expression of acetyl-CoA carboxylase 1(ACC1), a target gene of SREBP-1, increased in the female rats treated with 450 μg triptolide/kg/day, and ACC1 expression contributed to the sex-related differences in the triptolide-induced dysfunction of lipid metabolism. Our results demonstrate that the sex-related differences in LXR/SREBP-1-mediated regulation of gene expression in rats are responsible for the sex-related differences in lipid metabolism induced by triptolide, which likely underlie the sex-related differences in triptolide hepatotoxicity. This study will be important for predicting sex-related effects on the pharmacokinetics and toxicity of triptolide and for improving its safety.
Overlapping and non-redundant functions of the Arabidopsis auxin response factors MONOPTEROS and NONPHOTOTROPIC HYPOCOTYL 4

Transcription factors of the auxin response factor (ARF) family have been implicated in auxin-dependent gene regulation, but little is known about the functions of individual ARFs in plants. Here, interaction assays, expression studies and combinations of multiple loss- and gain-of-function mutants were used to assess the roles of two ARFs, NONPHOTOTROPIC HYPOCOTYL 4 (NPH4/ARF7) and MONOPTEROS (MP/ARF5), in Arabidopsis development. Both MP and NPH4 interact strongly and selectively with themselves and with each other, and are expressed in vastly overlapping domains. We show that the regulatory properties of both genes are far more related than suggested by their single mutant phenotypes. NPH4 and MP are capable of controlling both axis formation in the embryo and auxin-dependent cell expansion. Interaction of MP and NPH4 in Arabidopsis plants is indicated by their joint requirement in a number of auxin responses and by synergistic effects associated with the co-overexpression of both genes. Finally, we demonstrate antagonistic interaction between ARF and Aux/IAA gene functions in Arabidopsis development. Overexpression of MP suppresses numerous defects associated with a gain-of-function mutation in BODENLOS (BDL)/IAA12. Together these results provide evidence for the biological relevance of ARF-ARF and ARF-Aux/IAA interaction in Arabidopsis plants and demonstrate that an individual ARF can act in both invariantly programmed pattern formation as well as in conditional responses to external signals.
Applying the ISO 9126 quality model to test specifications - exemplified for TTCN-3 test specifications

Quality models are needed to evaluate and set goals for the quality of a software product. The international ISO/IEC standard 9126 defines a general quality model for software products. Software is developed in different domains and the usage of the ISO/IEC quality model requires an instantiation for each concrete domain. One special domain is the development and maintenance of test specifications. Test specifications for testing, e.g. the Internet Protocol version 6 (IPv6) or the Session Initiation Protocol (SIP), reach sizes of more than 40.000 lines of test code. Such large test specifications require strict quality assurance. In this paper, we present an adaptation of the ISO/IEC 9126 quality model to test specifications and show its instantiation for test specifications written in the Testing and Test Control Notation (TTCN-3). Example measurements of the standardised SIP test suite demonstrate the applicability of our approach.
STEADY-STATE PLASMA CONCENTRATIONS OF ITRACONAZOLE AFTER ORAL ADMINISTRATION IN KEMP'S RIDLEY SEA TURTLES, LEPIDOCHELYS KEMPI

Abstract Pharmacokinetic studies of antifungal agents in reptiles are uncommon. Itraconazole, which has been used prophylactically in juvenile sea turtles suffering from hypothermia (cold stunning) on a regular basis, was evaluated for steady-state plasma concentrations. Five Kemp's ridley sea turtles (Lepidochelys kempi) receiving itraconazole at several dosages in a rehabilitation program had blood collected within 24 hr to estimate dosing frequency. Subsequently, serial blood samples of Kemp's ridley sea turtles that were given itraconazole at several dosages for 30 days to treat cold stunning were collected at various intervals to evaluate itraconazole plasma concentrations. Tissue samples were collected from one Kemp's ridley that died during rehabilitation. Plasma concentrations of itraconazole (and of hydroxyitraconazole [OH-ITRA], one of its major bioactive metabolites) were determined using a modified, validated reverse-phase high-performance liquid chromatography technique. Itraconazole concentrations in tissues were determined by bioassay to be far greater than the plasma concentrations measured in any of the turtles. At a 15-mg/kg dosage, the half-life (t1/2) was 75 hr for itraconazole and 55 hr for OH-ITRA. All dosages produced adequate concentrations in some turtles, but consistent therapeutic concentrations were produced only at 15 mg/kg q72hr and 5 mg/kg s.i. d. , with the latter producing the highest plasma concentrations.
Trends in incidence, lifetime risk, severity, and 30-day mortality of stroke over the past 50 years.

CONTEXT Prior estimates of long-term trends in the incidence and severity of stroke have varied; trends in lifetime risk have not been reported. OBJECTIVE To determine long-term trends in the incidence, lifetime risk, severity, and 30-day mortality of clinical stroke. DESIGN, SETTING, AND PARTICIPANTS Prospective evaluation of the community-based Framingham Study original and offspring cohorts. Participants were 9152 men and women free of prevalent stroke and undergoing follow-up for up to 50 years over 3 consecutive periods (1950-1977, 1978-1989, and 1990-2004), with biennial ascertainment of stroke risk factor data and active surveillance for incident clinical stroke and cause-specific mortality. MAIN OUTCOME MEASURES Incidence (age-adjusted, sex-specific), severity, 30-day mortality, and mortality-adjusted 10-year and lifetime risk of stroke in each of the specified periods. RESULTS There were 1030 incident clinical strokes (450 [44%] in men, 629 atherothrombotic brain infarctions [61%]) in 9152 persons 55 years or older over 174,917 person-years of follow-up. The age-adjusted incidence of first stroke per 1000 person-years in each of the 3 periods was 7.6, 6.2, and 5.3, respectively, in men (P = .02 for trend) and 6.2, 5.8, and 5.1 in women (P = .01 for trend). The lifetime risk at age 65 years decreased from 19.5% to 14.5% in men (P = .11) and from 18.0% to 16.1% in women (P = .61). Age-adjusted stroke severity did not vary across periods; however, 30-day mortality decreased significantly in men (from 23% to 14%; P = .01) but not significantly in women (from 21% to 20%; P = .32). CONCLUSIONS In this cohort of men and women free of prevalent clinical stroke at initial examination, incidence of stroke has decreased over the past 50 years but the lifetime risk has not declined to the same degree, perhaps due to improved life expectancy. The results of this study suggest that improved control of risk factors has lowered stroke incidence but emphasize the need for continued primary prevention efforts.