Miracle-dz/UniFAR-FTUs huggingface dataset:
The Environmental Protection Agency's National SunWise School Program: sun protection education in US schools (1999-2000).

BACKGROUND Melanoma, the most fatal form of skin cancer, is rising at a rate faster than that of all preventable cancers except lung cancer in the United States. Childhood exposure to ultraviolet (UV) light increases the risk for skin cancer as an adult; thus starting positive sun protection habits early may be key to reducing incidence. METHODS We evaluated the US Environmental Protection Agency's SunWise School Program, a national, environmental education program for sun safety of children in primary and secondary schools (kindergarten through eighth grade). The program was evaluated with surveys administered to participating students. An identical 18-question, self-administered survey was completed by students (median age, 10 years) in the classroom before and immediately after the SunWise educational program. RESULTS Surveys were completed by students in 40 schools before (pretests; n = 1894) and after the program was presented (post-tests; n = 1815). Significant improvement was noted for the 3 knowledge variables: appropriate type of sunscreen to be used for outdoor play, highest UV Index number, and need for hats and shirts outside. Intentions to play in the shade increased from 73% to 78% (P <.001), with more modest changes in intentions to use sunscreen. Attitudes regarding healthiness of a tan also decreased significantly. CONCLUSIONS Brief, standardized sun protection education can be efficiently interwoven into school health education and result in improvements in knowledge and positive intentions for sun protection.
Robust Magnetic Tracking of Subsea Cable by AUV in the Presence of Sensor Noise and Ocean Currents

To inspect subsea cables, an autonomous underwater vehicle (AUV) with two triaxial magnetometers is usually assigned to track the cable route. In this paper, a novel two-layer framework synthesizing antinoise cable localization and robust tracking algorithm is proposed to guide an AUV to track subsea cables in the presence of sensor noise and ocean currents. First, an analytic formulation for the cable localization using two magnetometers is derived, and then a dedicated magnetic line-of-sight (LOS) guidance is built based on the horizontal offset between the AUV and the cable. Second, a novel antinoise method by estimating the horizontal offset is integrated into the LOS guidance law to reduce the negative effects of magnetic noise in the kinematic layer. Subsequently, in the dynamic layer, a simplified yet robust feedback controller with reduced implementation complexity is designed to track the desired guidance profiles, such that the AUV is able to track subsea cables in the presence of sensor noise and ocean currents. In addition, the capability of dynamic control laws accounting for ocean currents is analyzed in the amplitude–frequency domain. Finally, numerical studies illustrate the antinoise and robust performance of the proposed two-layer framework for subsea cable tracking.
Northern Bobwhite (Colinus virginianus) Mitochondrial Population Genomics Reveals Structure, Divergence, and Evidence for Heteroplasmy

Herein, we evaluated the concordance of population inferences and conclusions resulting from the analysis of short mitochondrial fragments (i.e., partial or complete D-Loop nucleotide sequences) versus complete mitogenome sequences for 53 bobwhites representing six ecoregions across TX and OK (USA). Median joining (MJ) haplotype networks demonstrated that analyses performed using small mitochondrial fragments were insufficient for estimating the true (i.e., complete) mitogenome haplotype structure, corresponding levels of divergence, and maternal population history of our samples. Notably, discordant demographic inferences were observed when mismatch distributions of partial (i.e., partial D-Loop) versus complete mitogenome sequences were compared, with the reduction in mitochondrial genomic information content observed to encourage spurious inferences in our samples. A probabilistic approach to variant prediction for the complete bobwhite mitogenomes revealed 344 segregating sites corresponding to 347 total mutations, including 49 putative nonsynonymous single nucleotide variants (SNVs) distributed across 12 protein coding genes. Evidence of gross heteroplasmy was observed for 13 bobwhites, with 10 of the 13 heteroplasmies involving one moderate to high frequency SNV. Haplotype network and phylogenetic analyses for the complete bobwhite mitogenome sequences revealed two divergent maternal lineages (d XY = 0.00731; F ST = 0.849; P < 0.05), thereby supporting the potential for two putative subspecies. However, the diverged lineage (n = 103 variants) almost exclusively involved bobwhites geographically classified as Colinus virginianus texanus, which is discordant with the expectations of previous geographic subspecies designations. Tests of adaptive evolution for functional divergence (MKT), frequency distribution tests (D, F S) and phylogenetic analyses (RAxML) provide no evidence for positive selection or hybridization with the sympatric scaled quail (Callipepla squamata) as being explanatory factors for the two bobwhite maternal lineages observed. Instead, our analyses support the supposition that two diverged maternal lineages have survived from pre-expansion to post-expansion population(s), with the segregation of some slightly deleterious nonsynonymous mutations.
The Gills of Reef Fish Support a Distinct Microbiome Influenced by Host-Specific Factors

ABSTRACT Teleost fish represent the most diverse of the vertebrate groups and play important roles in food webs, as ecosystem engineers, and as vectors for microorganisms. However, the microbial ecology of fishes remains underexplored for most host taxa and for certain niches on the fish body. This is particularly true for the gills, the key sites of respiration and waste exchange in fishes. Here we provide a comprehensive analysis of the gill microbiome. We focus on ecologically diverse taxa from coral reefs around Moorea, sampling the gills and intestines of adults and juveniles representing 15 families. The gill microbiome composition differed significantly from that of the gut for both adults and juveniles, with fish-associated niches having lower alpha diversity values and higher beta diversity values than those for seawater, sediment, and alga-associated microbiomes. Of ∼45,000 operational taxonomic units (OTUs) detected across all samples, 11% and 13% were detected only in the gill and the intestine, respectively. OTUs most enriched in the gill included members of the gammaproteobacterial genus Shewanella and the family Endozoicimonaceae. In adult fish, both gill and intestinal microbiomes varied significantly among host species grouped by diet category. Gill and intestinal microbiomes from the same individual were more similar to one another than to gill and intestinal microbiomes from different individuals. These results demonstrate that distinct body sites are jointly influenced by host-specific organizing factors operating at the level of the host individual. The results also identify taxonomic signatures unique to the gill and the intestine, confirming fish-associated niches as distinct reservoirs of marine microbial diversity. IMPORTANCE Fish breathe and excrete waste through their gills. The gills are also potential sites of pathogen invasion and colonization by other microbes. However, we know little about the microbial communities that live on the gill and the factors shaping their diversity. Focusing on ecologically distinct types of coral reef fish, we provide a comprehensive analysis of the fish gill microbiome. By comparison to microbiomes of the gut and the surrounding environment, we identify microbes unique to the gill niche. These microbes may be targets for further studies to determine the contribution of the microbiome to waste exchange or host immunity. We also show that despite exhibiting a unique taxonomic signature, the gill microbiome is influenced by factors that also influence the gut microbiome. These factors include the specific identity of the host individual. These results suggest basic principles describing how association with fishes structures the composition of microbial communities.
Web relation extraction with distant supervision

Being able to find relevant information about prominent entities quickly is the main reason to use a search engine. However, with large quantities of information on the World Wide Web, real time search over billions of Web pages can waste resources and the end user’s time. One of the solutions to this is to store the answer to frequently asked general knowledge queries, such as the albums released by a musical artist, in a more accessible format, a knowledge base. Knowledge bases can be created and maintained automatically by using information extraction methods, particularly methods to extract relations between proper names (named entities). A group of approaches for this that has become popular in recent years are distantly supervised approaches as they allow to train relation extractors without text-bound annotation, using instead known relations from a knowledge base to heuristically align them with a large textual corpus from an appropriate domain. This thesis focuses on researching distant supervision for the Web domain. A new setting for creating training and testing data for distant supervision from the Web with entity-specific search queries is introduced and the resulting corpus is published. Methods to recognise noisy training examples as well as methods to combine extractions based on statistics derived from the background knowledge base are researched. Using co-reference resolution methods to extract relations from sentences which do not contain a direct mention of the subject of the relation is also investigated. One bottleneck for distant supervision for Web data is identified to be named entity recognition and classification (NERC), since relation extraction methods rely on it for identifying relation arguments. Typically, existing pre-trained tools are used, which fail in diverse genres with non-standard language, such as the Web genre. The thesis explores what can cause NERC methods to fail in diverse genres and quantifies different reasons for NERC failure. Finally, a novel method for NERC for relation extraction is proposed based on the idea of jointly training the named entity classifier and the relation extractor with imitation learning to reduce the reliance on external NERC tools. This thesis improves the state of the art in distant supervision for knowledge base population, and sheds light on and proposes solutions for issues arising for information extraction for not traditionally studied domains.
Smart self-tightening surgical suture from a tough bio-based hyperbranched polyurethane/reduced carbon dot nanocomposite

Design and fabrication of a smart bio-based polymeric material with potent biocompatibility and high performance still remain a challenge in the biomedical realm. In this context, a potential smart suture was fabricated from starch modified hyperbranched polyurethane (HPU) nanocomposites with different weight percentages of reduced carbon dots for the first time. The desired mechanical (tensile strength: 32.14 MPa, elongation at break: 1576% and toughness 439.28 MJ m−3) and thermal (286 °C) attributes of the suture were achieved with 2 wt% of reduced carbon dots in an HPU matrix. The non-contact self-tightening behavior was observed just within 15 s at body temperature of 37 °C ± 1 °C with notable shape fixity (99.6%) and shape recovery (99.7%) effects. The nanocomposites displayed in vitro biodegradability and hemocompatibility. Low lactate dehydrogenase activity and minimal red blood cell lysis indicated the anti-thrombogenicity and anti-hemolytic properties of the nanocomposites. The suitability of the fabricated nanocomposites as a smart biomaterial was supported by the inherent biocompatibility as observed by the growth and proliferation of smooth muscle cells and endothelial cells. Furthermore, they exhibited minimal immunogenic response (TNF α release). Thus, the study paves the way to biodegradable HPU nanocomposites as advanced non-contact triggered rapid self-tightening surgical sutures for biomedical applications.
Effects of varenicline on alcohol self-administration and craving in drinkers with depressive symptoms

Varenicline (VAR) is approved to aid in smoking cessation and has been shown to be effective for reducing alcohol consumption in heavy drinkers. Little is known, however, about treatment moderators that may influence efficacy. The current study reanalyzed data from a human laboratory study (Verplaetse et al., 2016) to determine whether VAR was more effective at reducing alcohol use among drinkers reporting symptoms of depression. Participants were 60 adults meeting DSM-IV criteria for alcohol use disorders (n = 60) who were randomly assigned to receive VAR (1 mg/day, 2 mg/day) or placebo. Following 7 days of medication pretreatment, participants attended a laboratory testing session. They provided self-reported ratings of alcohol craving and performed an ad libitum alcohol consumption task after receiving a priming dose of alcohol (target blood alcohol concentration = 0.030 g/dL). Higher blood VAR plasma levels were associated with less alcohol craving and less drinking among participants with more depressive symptoms. Among participants with fewer depressive symptoms, VAR was associated with more drinking during the ad libitum drinking task. These findings show that depression symptoms may be a moderator of VAR efficacy in alcohol users and provides evidence for the role of nAChRs in depression and alcohol use.
A blueprint for demonstrating quantum supremacy with superconducting qubits

Scaling up to supremacy Quantum information scientists are getting closer to building a quantum computer that can perform calculations that a classical computer cannot. It has been estimated that such a computer would need around 50 qubits, but scaling up existing architectures to this number is tricky. Neill et al. explore how increasing the number of qubits from five to nine affects the quality of the output of their superconducting qubit device. If, as the number of qubits grows further, the error continues to increase at the same rate, a quantum computer with about 60 qubits and reasonable fidelity might be achievable with current technologies. Science, this issue p. 195 Scaling of errors and output with the number of qubits is explored in a five- to nine-qubit device. A key step toward demonstrating a quantum system that can address difficult problems in physics and chemistry will be performing a computation beyond the capabilities of any classical computer, thus achieving so-called quantum supremacy. In this study, we used nine superconducting qubits to demonstrate a promising path toward quantum supremacy. By individually tuning the qubit parameters, we were able to generate thousands of distinct Hamiltonian evolutions and probe the output probabilities. The measured probabilities obey a universal distribution, consistent with uniformly sampling the full Hilbert space. As the number of qubits increases, the system continues to explore the exponentially growing number of states. Extending these results to a system of 50 qubits has the potential to address scientific questions that are beyond the capabilities of any classical computer.
Resting connectivity between salience nodes predicts recognition memory

Abstract The resting connectivity of the brain’s salience network, particularly the ventral subsystem of the salience network, has been previously associated with various measures of affective reactivity. Numerous studies have demonstrated that increased affective arousal leads to enhanced consolidation of memory. This suggests that individuals with greater ventral salience network connectivity will exhibit greater responses to affective experience, leading to a greater enhancement of memory by affect. To test this hypothesis, resting ventral salience connectivity was measured in 41 young adults, who were then exposed to neutral and negative affect inductions during a paired associate memory test. Memory performance for material learned under both negative and neutral induction was tested for correlation with resting connectivity between major ventral salience nodes. The results showed a significant interaction between mood induction (negative vs neutral) and connectivity between ventral anterior insula and pregenual anterior cingulate cortex, indicating that salience node connectivity predicted memory for material encoded under negative, but not neutral induction. These findings suggest that the network state of the perceiver, measured prior to affective experience, meaningfully influences the extent to which affect modulates memory. Implications of these findings for individuals with affective disorder, who show alterations in both connectivity and memory, are considered.
Botulinum Toxin in Migraine Treatment

Ya z›fl ma Ad re si/Cor res pon den ce Ad dress Elif Ilgaz Aydınlar MD, Acıbadem University, Medical Faculty, Department of Neurology, İstanbul, Turkey Gsm: +90 212 304 44 55 E-posta: ilgaz2000@yahoo.com Re cei ved/Ge liş ta ri hi: 02.04. 2013 Ac cep ted/Ka bul ta ri hi: 17.04. 2013 © Arc hi ves of Neu ropsy chi atry, pub lis hed by Ga le nos Pub lis hing / © Nö rop si ki yat ri Ar şi vi Der gi si, Ga le nos Ya yı ne vi ta ra f›n dan ba s›l m›fl t›r. Review Article Doi: 10.4274/npa.y7198
Malignant Ectomesenchymoma: Series Analysis of a Histologically and Genetically Heterogeneous Tumor

Aims. Malignant ectomesenchymoma is a rare pediatric neoplasm with dual mesenchymal and neuroectodermal elements. Mesenchymal component is usually rhabdomyosarcoma, particularly embryonal subtype, whereas neuroectodermal derivatives are frequently a neuroblastic tumor. Ectomesenchymoma manifests in various sites given the wide migration of neural crest cells during development, though the pelvis/perineum is most often involved. Moreover, no unique unifying molecular abnormality has been determined. Methods. We conducted a retrospective study to analyze the spectrum of ectomesenchymal tumors encountered in our pediatric population. Six patients were identified and data pertaining to patients’ demographic, tumor size and site, histologic components with immunophenotypic profile, molecular alterations, treatment, and outcome were collected. Results. Mesenchymal elements, represented by rhabdomyosarcoma in all instances, were the dominant component in the majority of cases (5/6). Embryonal and alveolar morphology had similar distribution (3/6) and all patients with alveolar subtype harbored the characteristic translocations of this entity. The neuroectodermal component was most often a neuroblastic-like neoplasm (4/6); however, 2/6 cases demonstrated primitive neuroectodermal tumor-like morphology. No unifying alterations were found on molecular studies. Conclusions. Our analysis extends the histologic and molecular spectrum of these tumors and highlights their heterogeneity. The percentage of cases with alveolar rhabdomyosarcoma or primitive neuroectodermal-like tumor components suggests that these types of elements might be underreported. This study is also the first to demonstrate FOXO1 gene rearrangements in malignant ectomesenchymoma with alveolar rhabdomyosarcoma subtype.
Effectiveness and Safety of Topical Phototherapy in the Treatment of Dermatological Diseases

Phototherapy consists in the use of ultraviolet (UV) radiation from artificial sources for therapeutic purposes. Despite the introduction of new and powerful drugs (including biological and target therapies), phototherapy remains an established, lower cost, and effective option for the treatment of many common skin diseases. In systemic photochemotherapy or PUVA, photosensitizing agents of the family of Psoralens are used in combination with UVA, i.e. with long wave ultraviolet radiation . Psoralens strongly enhance the effect of UVA alone, as they interact with biological macromolecules, causing the production of oxygen free radicals within the photoacti‐ vated cells. However, systemic administration of psoralens can be problematic, causing possible negative interactions with other drugs and the onset of serious side effects. To counteract these limitations, it has been developed the bath‐PUVA therapy, which consists in the topical administration of psoralens by bathing the whole body surface in an alcoholic solution of 8‐methoxypsoralen (8‐MOP); immediately afterwards this pre‐ treatment, the patient is UVA‐irradiated. This technique has several advantages over conventional PUVA, including the use of a reduced UVA dosage, thus resulting in minimal skin damage with complete elimination of skin photosensitivity within three hours after the treatment; furthermore, it virtually eliminates systemic side effects and drug interference due to the very limited percutaneous absorption of psoralens. Bath‐ PUVA is indicated and effective in the treatment of many chronic inflammatory dermatoses (including psoriasis, atopic and allergic dermatitis, lichen ruber planus, chronic urticaria, and mastocitosis), autoimmune skin diseases (including vitiligo, and alopecia aerata), and premalignant/malignant systemic absorption of the psoralen. Ultraviolet A (UVA) irradiation is administered by cabins or partial devices according to the extension of the body areas to be treated. Gel‐ PUVA has produced its best responses in morfea, palmo‐plantar psoriasis, contact dermatitis and vitiligo. The purpose of this chapter is to provide a detailed description of the various phototherapy techniques and discuss their possible applications to the treatment of specific acute and chronic skin diseases.