Miracle-dz/UniFAR-FTUs huggingface dataset:
Complications and failure after total ankle arthroplasty.

BACKGROUND Second-generation total ankle arthroplasty has been reported to have good intermediate-term results. The purpose of the present study was to report on the cause and frequency of reoperation and failure after total ankle arthroplasty and to determine demographic and clinical predictors of reoperation and failure. METHODS Three hundred and six consecutive primary total ankle arthroplasties were performed with use of the DePuy Agility Total Ankle System between 1995 and 2001. At a mean of thirty-three months after the arthroplasty, we retrospectively reviewed the records with regard to patient age, gender, the indications for the index procedure, adjuvant procedures, the timing and frequency of reoperation, and the indications for and the type of reoperations performed. Kaplan-Meier analysis was performed to determine the rate of prosthetic survival, and Cox regression analysis was performed to determine predictors of reoperation and failure. RESULTS Eighty-five patients (28%) underwent 127 reoperations (involving 168 procedures) after primary total ankle arthroplasty. The most common procedures at the time of reoperation were débridement of heterotopic bone (fifty-eight), correction of axial malalignment (forty), and component replacement (thirty-one). Eight patients underwent below-the-knee amputation. Age was found to be the only significant predictor of reoperation and failure after total ankle arthroplasty. The five-year survival rate with reoperation as the end point was 54%. The five-year survival rate with failure as the end point was 80% for all patients and 89% for patients who were more than fifty-four years of age. The prosthesis could not be salvaged in nine ankles (2.9%); the inability to salvage the prosthesis was most often due to loosening or infection. CONCLUSIONS We noted a relatively high rate of reoperation after total ankle arthroplasty with this second-generation device. Younger age was found to have a negative effect on the rates of reoperation and failure. Most prostheses could be salvaged; however, the functional outcome of this procedure is uncertain.
A Consistent Theory for Linear Waves of the Shallow-Water Equations on a Rotating Plane in Midlatitudes

The present study provides a consistent and unified theory for the three types of linear waves of the shallow-water equations (SWE) in a zonal channel on the plane: Kelvin, inertia–gravity (Poincare ´ ), and planetary (Rossby). The new theory is formulated from the linearized SWE as an eigenvalue problem that is a variant of the classical Schrodinger equation. The results of the new theory show that Kelvin waves exist on the plane with vanishing meridional velocity, as is the case on the f plane, without any change in the dispersion relation, while the meridional structure of their height amplitude is trivially modified from exponential on the f plane to a one-sided Gaussian on the plane. Similarly, inertia–gravity waves are only slightly modified in the new theory in comparison with their characteristics on the f plane. For planetary waves (which exist only on the plane) the new theory yields a similar dispersion relation to the classical theory only for large gravity wave phase speed, such as those encountered in a barotropic ocean or an equivalent barotropic atmosphere. In contrast, for low gravity wave phase speed, for example, those in an equivalent barotropic ocean where the relative density jump at the interface is 10 3 , the phase speed of planetary waves in the new theory is 2 times those of the classical theory. The ratio between the phase speeds in the two theories increases with channel width. This faster phase propagation is consistent with recent observation of the westward propagation of crests and troughs of sea surface height made by the altimeter aboard the Ocean Topography Experiment (TOPEX)/Poseidon satellite. The new theory also admits inertial waves, that is, waves that oscillate at the local inertial frequency, as a genuine solution of the eigenvalue problem.
MT1-MMP Cleavage of the Antiangiogenic Proteoglycan Decorin: Role in Corneal Angiogenesis

PURPOSE Decorin is a small chondroitin sulfate proteoglycan that inhibits vascular endothelial cell migration and tube formation. Membrane type 1-matrix metalloproteinase (MT1-MMP) has been shown to be an important angiogenic enzyme in the cornea. We evaluated the specific role of MT1-MMP in decorin cleavage in the cornea. METHODS Western blotting was used to evaluate decorin degradation by MT1-MMP. Aortic ring tube formation assays were used to assay the inhibitory effect of decorin and the stimulatory effect of MT1-MMP on vascular endothelial cells in vitro. Corneal micropocket assays using basic fibroblast growth factor (bFGF) were used to assess changes in the levels of decorin and MT1-MMP. RESULTS MT1-MMP cleaves decorin in a time- and concentration-dependent manner in vitro. MT1-MMP levels were upregulated after in vivo bFGF pellet implantation in the cornea, and decorin cleavage products were detected in bFGF-implanted corneas but not in normal corneas. MT1-MMP reduced the inhibitory effects of decorin on aortic ring tube formation in vitro. CONCLUSION MT1-MMP may play an essential role in angiogenesis through proteolytic processing of decorin in the cornea.
Mobile Design as Neighborhood Acupuncture: Activating the Storytelling Networks of South Los Angeles

Abstract A delicate touch is required to empower neighborhoods using civic media. Funding is persistently scarce. Especially in marginalized neighborhoods, blunt designs can be counterproductive and even entrench complex problems. New metaphors may be needed to guide design and empower local neighborhoods. Urban acupuncture is used as the basis for this study, emphasizing a light-touch strategy that has shown success in Brazil with urban transit, and more recently in Europe with urban design. We specifically propose “neighborhood acupuncture” to address the local level, tapping the sociology of place-based communication. To investigate the implications for systematic design, a case study is probed in South Los Angeles using mobile media for community mapping. Using qualitative methods, three tactics were investigated for the potential to “poke” the network into action, including one to bridge diverse storytelling networks. Each tactic ultimately seeks to build the capacity for collective action around neighborhood issues. Acupuncture is broadly argued to sustain two design shifts: first to help approach neighborhoods as ecosystems, and second, to design for circulation rather than any single technology platform.
Daughters and Left-Wing Voting

This paper provides evidence that daughters make people more left-wing. Having sons, by contrast, makes them more right-wing. Parents, politicians and voters are probably not aware of this phenomenon - nor are social scientists. The paper discusses its economic and evolutionary roots. It also speculates on where research might lead. The paper ends with a conjecture: left-wing individuals are people who come from families into which, over recent past generations, many females have been born.
The effect of point mutations on the free energy of transmembrane alpha-helix dimerization.

Glycophorin A forms homodimers through interaction of the single, helical transmembrane domains of the monomers. The dimers are stable in sodium dodecylsulfate (SDS), permitting a number of studies that have identified a critical motif of residues that mediates dimer formation. We have used analytical ultracentrifugation to measure the energy of dimerization in a non-denaturing detergent solution and have observed the changes in energy arising from two of the mutants previously studied. Use of the detergent pentaoxyethylene octyl ether (C8E5) is a great advantage, since its micelles are neutrally buoyant and the detergent allows a reversible association to occur between monomer and dimer states of the glycophorin A transmembrane helices during the time-scale of sedimentation equilibrium. Use of this detergent in analytical ultracentrifugation may enable a wide range of studies of molecular association events in membrane proteins. We find that the glycophorin A transmembrane helix dimerizes with a dissociation constant of 240(+/-50) nM, corresponding to a free energy of dissociation of 9.0(+/-0.1) kcal mol-1. Point mutants that were found to be disruptive in SDS (L75A, I76A) reduced the dimer affinity in the C8E5 detergent environment (Kd=1.7(+/-0.2) microM and 4.2(+/-0.9) microM, respectively). Thus, the earlier findings are placed on a quantitative, relative energy scale of association by our measurements. Molecular modeling and simulations suggest that the energy differences can be accounted for as changes in van der Waals interactions between helices.
Recent Developments in the Modeling, Analysis, and Numerics of Ferromagnetism

Micromagnetics is a continuum variational theory describing magnetization patterns in ferromagnetic media. Its multiscale nature due to different inherent spatiotemporal physical and geometric scales, together with nonlocal phenomena and a nonconvex side-constraint, leads to rich behavior and pattern formation. This variety of effects is also the reason for severe problems in analysis, model validation, reductions, and numerics, which have only recently been accessed and are reviewed in this work.
Introduction : constraints in phonological acquisition

This volume presents ten studies in phonological first language acquisition, an area of research that has become one of fast-growing importance in recent years. The reason for this is not just the fruitfulness and linguistic interest of this type of study per se: it is also the case that the more we come to know about phonological development, by the analysis of growing numbers of data collections and increasingly sophisticated experiments, the more the field has complied with the notion that acquisition research lies at the heart of the modern study of language. One of the aims of this introduction is to illustrate and discuss these developments. In line with them, the past decade in phonology in particular has witnessed an upswell of productive interaction between empirical acquisition research and theory development. With thearrival and rise of constraint-based models, in particular Prince and Smolensky's (1993) Optimality Theory, phonological theory now provides a framework that meets the desiderata expressed more than two decades ago by Lise Menn (1980: 35-36), who is also a contributor to this volume:
Inferring Emergent Web Communities

|One of the characteristic features of the World Wide Web is that it allows anyone to access information on almost any subject that is of interest to that person. The emergent result of this process is that communities arise that are focused around subjects of common interest. Identifying these communities can be challenging, since in contrast to the communities that have been formed more traditionally by people sharing a common interest because they are located in physically adjacent spaces, geographic proximity is not present on the Web. In this paper, we discuss methods of detecting communities on the Web. Keywords|Datamining, Networking
Kidney-specific proteins in elderly patients undergoing cardiac surgery with cardiopulmonary bypass.

UNLABELLED In cardiac surgery, acute renal failure (ARF) is more likely in elderly patients than in younger patients. We assessed whether kidney function is different between elderly and younger cardiac surgery patients by measuring kidney-specific proteins. Forty consecutive patients aged <60 yr and 40 patients aged >70 yr without preoperative kidney dysfunction undergoing elective cardiac surgery with cardiopulmonary bypass (CPB) were included. Creatinine clearance and fractional excretion of sodium, as well as urine concentrations of N-acetyl-beta-D-glucosaminidase, alpha-1-microglobulin, glutathione transferase-pi (GST-pi), and glutathione transferase-alpha (GST-alpha) were measured after induction of anesthesia, at the end of surgery, and at the first and second postoperative days (PODs) on the intensive care unit. Patients' ages were 54 +/- 4 and 77 +/- 3 yr, respectively. Preoperative creatinine concentrations were without significant differences between the two groups. Fractional excretion of sodium was significantly higher after bypass in the elderly than in the younger patients. Urine concentrations of all kidney-specific proteins increased after CPB in the elderly (e.g., GST-pi from 16.2 +/- 3.4 to 27.7 +/- 3.9 microg/L), whereas they remained almost unchanged in the younger patients. Concentrations of all kidney-specific proteins were significantly larger in the elderly than in the younger patients even at the second POD. Although none of our patients suffered ARF requiring dialysis, increased post-CPB urine concentrations of kidney-specific proteins in the elderly suggest discrete and transient alterations in kidney integrity in comparison with a younger patient population undergoing cardiac surgery. IMPLICATIONS Measurement of kidney-specific proteins demonstrated that patients >70 yr (mean, 77 +/- 3 yr) undergoing cardiac surgery with cardiopulmonary bypass had moderate and transient alterations in kidney integrity compared with patients aged <60 yr (mean, 54 +/- 4 yr). These abnormalities were not detected with standard measures of kidney function (e.g., creatinine concentrations).
How Is Leisure Time Interacting with Nature Related to the Need for Recovery from Work Demands? Testing Multiple Mediators

The study compared the importance of spending time in interacting with nature to other leisure activities regarding recovery from work demands. In addition, a multiple mediation model between time spent in interacting with nature and need for recovery through four mediators was tested. Employees of five organizations answered a questionnaire (N = 527). Exercise and being outdoors during free-time was evaluated as the most effective activity for recovery from work stress, and the time spent in interacting with nature was mentioned as second in importance. Time spent in exercise and being outdoors, life satisfaction, and relaxation mediated significantly the relationship between time spent in interacting with nature and need for recovery from work.
Retrograde axonal transport impairment of large- and medium-sized retinal ganglion cells in diabetic rat.

PURPOSE Several abnormalities in visual pathway functions in diabetic humans and animals have been reported. We demonstrated retrograde axonal transport impairment in retinal ganglion cells of streptozotocin-diabetic rats. METHODS Diabetes was induced in male Wistar albino rats by intraperitoneal injection of streptozotocin. Three months after the induction of diabetes, fluoro-gold was injected into the dorsal lateral geniculate nucleus. Percentages of fluoro-gold-labeled large-, medium- and small-sized retinal ganglion cells per total population were calculated in wholemount retinas of diabetic and control rats. The same sections were stained with cresyl violet and each retinal ganglion cell type evaluated by light microscopy. RESULTS Although a quantitative decrease in the population of each retinal ganglion cell type was not observed, mean percentages of fluoro-gold-labeled large- and medium-sized retinal ganglion cells per total population were significantly decreased in diabetic rats compared with controls. CONCLUSIONS Our results suggest that diabetes affects the retrograde axonal transport in large- and medium-sized retinal ganglion cells despite the absence of morphological changes in the perikaryon and decrease in total cell population. Diabetes-induced impairment of retrograde axonal transport in large- and medium-sized retinal ganglion cells precede optic nerve involvement. However, this may merely be a consequence of metabolic changes in diabetic states.
The Family Environment of Students Self-Appraised as Effective and Ineffective Problem Solvers

This study investigated differences in the family environment of students who appraised themselves as either effective or ineffective problem solvers. Subjects (n = 423) were undergraduate students at the University of the Western Cape, South Africa. Of these, 128 subjects who scored either 1 standard deviation above the mean on the Problem Solving Inventory (effective problem solvers) or 1 standard deviation below the mean (ineffective problem solvers) were compared in terms of the dimensions of the Family Environment Scale. Hotelling T and univariate t tests indicated a significant difference between the two groups. The Effective problem-solving group was characterised by higher scores on Cohesion, Expressiveness, Intellectual-Cultural Orientation, Active-Recreational Orientation, Moral-Religious Emphasis, and Organization as well as lower scores on Conflict. These results appear consistent with the importance attached to family environment as an important influence in personality development.
Living Within Limits: Unpleasant Experiences From the Perspective of Patients After Cardiac Surgery, a Content Analysis Study

Objectives: The aim of this study was to explore the lived experiences of patients who have undergone cardiac surgery, in order to obtain a deeper understanding of what they experienced and what those who provide care for these patients experienced. Patients and Methods: A qualitative design, using a content analysis approach, was adapted to collect the data and analyze the experiences of 18 patients after cardiac surgery through a purposive sampling strategy. After the selection of the participants, semi structured interviews were held in order to collect the data. Scientific accuracy, and rigor of the data and research ethics were respected. Results: The data analysis revealed three main themes and 11 subthemes, categorized as conceptual and abstract, based on their nature: concern of going out therapeutic framework (Fear of the recurrence of heart attack, Fear of performing more activities than permitted, Fear of taking journeys, Fear of mass communication)/Tired of living within the confines of the therapeutic framework (Need to take various medications, Dietary restrictions, Limitations in function, Family fatigue)/Living between boundaries (Feeling caught between wanting to accept or reject treatment, Feeling caught between the sadness of having the disease and the joy of it not getting worse, Feeling caught between knowing and not knowing). Conclusions: Patients' experiences after cardiac surgery indicated the need for the consideration of holistic care and supportive intervention programs after surgery to promote recovery and a better quality of life following cardiac surgery.
Apolipoprotein A‐I mimetic peptide L‐4F prevents myocardial and coronary dysfunction in diabetic mice

Diabetes is a major health problem associated with adverse cardiovascular outcomes. The apolipoprotein A‐I mimetic peptide L‐4F is a putative anti‐diabetic drug, has antioxidant and anti‐inflammatory proprieties and improves endothelial function. In obese mice L‐4F increases adiponectin levels, improving insulin sensitivity, and reducing visceral adiposity. We hypothesized that the pleiotropic actions of L‐4F can prevent heart and coronary dysfunction in a mouse model of genetically induced Type II diabetes. We treated db/db mice with either L‐4F or vehicle for 8 weeks. Trans‐thoracic echocardiography was performed; thereafter, isolated hearts were subjected to ischemia/reperfusion (IR). Glucose, insulin, adiponectin, and pro‐inflammatory cytokines (IL‐1β, TNF‐α, MCP‐1) were measured in plasma and HO‐1, pAMPK, peNOS, iNOS, adiponectin, and superoxide in cardiac tissue. In db/db mice L‐4F decreased accumulation of subcutaneous and total fat, and increased insulin sensitivity and adiponectin levels while lowering inflammatory cytokines (P < 0.05). L‐4F normalized in vivo left ventricular (LV) function of db/db mice, increasing (P < 0.05) fractional shortening and decreasing (P < 0.05) LV dimensions. In I/R experiments, L‐4F prevented coronary microvascular resistance from increasing and LV function from deteriorating in the db/db mice. These changes were associated with increased cardiac expression of HO‐1, pAMPK, peNOS, and adiponectin and decreased levels of superoxide and iNOS (P < 0.01). In the present study we showed that L‐4F prevented myocardial and coronary functional abnormalities in db/db mice. These effects were associated with stimulation of HO‐1 resulting in increased levels of anti‐inflammatory, anti‐oxidative, and vasodilatatory action through a mechanism involving increased levels of adiponectin, pAMPK, and peNOS. J. Cell. Biochem. 112: 2616–2626, 2011. © 2011 Wiley‐Liss, Inc.
Effect of exercise, heat stress, and hydration on immune cell number and function.

PURPOSE The purpose of this study was to determine the effect of thermal stress and hydration status on immune function during exercise. METHODS Ten trained men completed four cycle ergometer rides at 55% VO2peak under the following conditions: EN (euhydrated neutral; 22 degrees C, 30% RH), DN (dehydrated neutral), EH (euhydrated hot; 38 degrees C, 45% RH), and DH (dehydrated hot). During EN and EH, a carbohydrate/electrolyte beverage was consumed at a rate matching sweat loss, and during DN and DH, no fluid was ingested. Blood samples were drawn pre- and postexercise, and at 2 and 24 h of recovery. Cell counts were determined by automated counting and flow cytometry. Neutrophil activity was assessed as superoxide production, lymphocyte function was determined via PHA-stimulated mitogenesis, and natural killer (NK) cell activity was measured with a 51Cr-release assay. Cortisol was assayed via RIA. RESULTS Lymphocytes proliferation was depressed 2 h after exercise in all conditions (P < 0.05); however, when expressed on a per cell basis, function was greater in the DH and EH conditions. NK activity (max x 10(3) cells) was greater post compared with preexercise in all conditions (EH = 25.5 +/- 16.8, DH = 26.2 +/- 10.5, EN = 19.3 +/- 11.0, and DN = 16.5 +/- 8.7) but was not different between conditions. Leukocyte, neutrophil, lymphocyte, and NK cell counts were also elevated postexercise with the former two remaining elevated 2 h postexercise in the EH and DH conditions. Cortisol was greater postexercise in EH (22.1 +/- 1.3) and DH (27.7 +/- 1.3) compared with EN (17.8 +/- 2.1) and DN (18.9 +/- 1.6 microg x dL(-1). CONCLUSION Euhydration did not affect cell number or function when compared with a dehydrated state; however, the hot environment caused more severe disturbances in these measures compared with a neutral environment.
The effects of alcohol on interrogative suggestibility: The role of State-Anxiety and mood states as mediating factors

Purpose. The goal of this study was to determine whether alcohol would increase or decrease interrogative suggestibility. Methods. Four groups of participants (N = 51) were administered the story and immediate recall of the Gudjonsson Suggestibility Scale 2. After this they were administered one of three doses of alcohol or a placebo followed by delayed recall and the questioning part of the scale. Changes in mood and anxiety were monitored with the help of Profile of Mood States and Spielberger State-Anxiety Scale. Results. Alcohol decreased yielding to leading questions both before (Yield 1) and after (Yield 2) interrogative pressure was applied but had no effect on changing answers in response to the pressure (Shift). State-Anxiety and Clearheaded-Confused mood were found to mediate the effects of alcohol on Yield 2. No other significant mediational relationships were found. Conclusions. Alcohol appears to decrease suggestibility with the exception of reactions to applied interrogative pressure. This decrease is not totally explainable by the mediating effects of either mood states or anxiety. Language: en