Miracle-dz/UniFAR-FTUs huggingface dataset:
Helmholtz-Zentrum Dresden-Rossendorf (HZDR) On the estimation of ultimate tensile stress from small punch testing

Finite element simulations of the small punch test are performed in order to critically evaluate and improve empirical correlations for the estimation of the ultimate tensile stress from force-deflection and force-displacement curves. For this purpose, generic elastic-plastic material properties are used. A systematic variation of the ultimate tensile stress and total uniform elongation is performed to investigate the effects of these parameters of the uniaxial stress-strain curve on the characteristics of small punch test curves. It is shown, that the maximum force Fm of the small punch test curve is not the appropriate parameter for the estimation of the ultimate tensile stress. Instead, the force Fi at a punch displacement of 1.29 times the specimen thickness (or alternatively at bottom deflection of 1.1 times the specimen thickness) should be used. This force is associated with the onset of plastic instability. A correlation between the force Fi and the ultimate tensile strength is proposed and validated by more than 100 small punch tests of nine different steel heats.
Causes of death and the components of mortality: Testing the biological interpretations of a competing hazards model

Biological interpretations of a competing hazards model intended to express the age pattern of mortality throughout the life span are evaluated using cause of death data. The model examined is the Siler model, which consists of three competing hazards, immature, residual, and senescent. The data employed are the worldwide sample of life tables and decremented life tables, that is, life tables with a cause of death eliminated, assembled by Preston et al. (Causes of Death Life Tables for National Populations. New York: Seminar Press, 1972). The results indicate that causes of death are accounted for by the model in a manner consistent with the biological interpretations of the hazard functions. For example, the cardiovascular diseases, neoplasms, and other degenerative diseases are accounted for by the senescent component of morality. This is a valuable characteristic of the model that may prove useful for assessing errors in cause of death data and identifying variation in the impact of a cause of death on the age patterns of mortality. For example, only 30% of deaths classified as due to other and unknown causes are attributed by the model to the senescent component of mortality and are consequently likely to be due to degenerative diseases. This finding contradicts the conventional assumption that the majority of other and unknown causes of death are due to the degenerative diseases. Additional results show that certain causes of death, such as influenza, pneumonia, and bronchitis, can occur in different components of mortality, suggesting that some categories of death may express several different etiologies. Partial correlation analysis indicates that much of this variation in etiology occurs among (and not within) populations. It is concluded that the Siler model is a useful framework for studying historical and/or cross‐national trends in mortality.
Behavioral Interventions for Anger, Irritability, and Aggression in Children and Adolescents.

OBJECTIVE Anger, irritability, and aggression are among the most common reasons for child mental health referrals. This review is focused on two forms of behavioral interventions for these behavioral problems: Parent management training (PMT) and cognitive-behavioral therapy (CBT). METHODS First, we provide an overview of anger/irritability and aggression as the treatment targets of behavioral interventions, followed by a discussion of the general principles and techniques of these treatment modalities. Then we discuss our current work concerning the transdiagnostic approach to CBT for anger, irritability, and aggression. RESULTS PMT is aimed at improving aversive patterns of family interactions that engender children's disruptive behavior. CBT targets deficits in emotion regulation and social problem-solving that are associated with aggressive behavior. Both forms of treatment have received extensive support in randomized controlled trials. Given that anger/irritability and aggressive behavior are common in children with a variety of psychiatric diagnoses, a transdiagnostic approach to CBT for anger and aggression is described in detail. CONCLUSIONS PMT and CBT have been well studied in randomized controlled trials in children with disruptive behavior disorders, and studies of transdiagnostic approaches to CBT for anger and aggression are currently underway. More work is needed to develop treatments for other types of aggressive behavior (e.g., relational aggression) that have been relatively neglected in clinical research. The role of callous-unemotional traits in response to behavioral interventions and treatment of irritability in children with anxiety and mood disorders also warrants further investigation.
Healthcare resource use and relapses with fingolimod versus natalizumab for treating multiple sclerosis: a retrospective US claims database analysis

Abstract Objective: Healthcare resource utilization in patients with multiple sclerosis (MS) is linked to relapses and disease progression. This retrospective cohort database analysis compared healthcare resource use and proxy measures of relapse outcomes in patients with active disease who switched to fingolimod or natalizumab. Methods: Using administrative claims data from the US PharMetrics Plus database, we identified patients with an MS diagnosis and a claim for fingolimod or natalizumab between 1 October 2010 and 30 June 2012 (index period) who had experienced a relapse (identified using a claims-based algorithm) and used other disease-modifying therapies (DMTs) in the previous year. Patients in the fingolimod and natalizumab cohorts were propensity score matched (1:1). MS-related inpatient stays, corticosteroid use and the proportion of patients experiencing claims-based relapses were assessed in the pre-index and post-index persistence periods. Time to first claims-based relapse in the post-index persistence period was assessed using a Kaplan–Meier curve. Results: The study included 623 unmatched patients (299 and 324 patients in the fingolimod and natalizumab cohorts, respectively) and 370 matched patients (185 in each cohort). In the matched analysis, MS-related inpatient stays and corticosteroid use were similar in the fingolimod and natalizumab cohorts during the post-index persistence period, and were significantly reduced versus the pre-index period (p < 0.01). A similar proportion of patients in the fingolimod and natalizumab cohorts were free from claims-based relapses in the persistence period (68.1% and 68.6%, respectively). There was no significant difference in the likelihood of experiencing a claims-based relapse (p = 0.8696). Limitation: Identification of relapses is based on database claims rather than on clinical assessment. Conclusions: In analyses of patients with MS with a history of relapse and DMT use, fingolimod and natalizumab reduce healthcare resource utilization and have similar effectiveness in a real-world setting.
Milking behaviour of buffalo cows: entrance order and side preference in the milking parlour

On two farms, three milking groups of buffalo cows were used to assess the consistency of entrance order and the preference for one side of the milking parlour. On Farm 1 (F1) all animals were primiparous (n=57). On Farm 2, three primiparous, 16 secondiparous and 36 multiparous cows (range 1–8) constituted group F2G1; whereas group F2G2 had 12 primiparous, 10 secondiparous and 14 multiparous cows (range 1–10). Animals were milked in auto-tandem milking parlours (2×5 and 2×6 for Farms 1 and 2, respectively). For each cow, entrance order into milking parlour, side where she was milked, milk yield, time and duration of milking were recorded. These data were derived from the computerised identification of cows. The sequence in which the cows entered the milking parlour ranged from 1 to 57 for group F1, from 1 to 55 for group F2G1 and from 1 to 36 for group F2G2. The analysis of data was conducted on 130, 120 and 92 consecutive milkings for groups F1, F2G1 and F2G2, respectively. Kendall's coefficients of concordance showed a strong constancy of the entrance order into milking parlour for groups F1 (W=0·658; χ2=4792·81; P<0·001), F2G1 (W=0·779; χ2=5046·81; P<0·001) and F2G2 (W=0·624; χ2=2030·48; P<0·001). Spearman rank correlation coefficients indicated that the more productive cows in groups F1 and F2G1 tended to enter the milking parlour first (r s=−0·221 and r s=−0·215; P<0·10; respectively). In group F2G1, a negative correlation was found between duration of milking and order of entry in the milking parlour (r s=−0·265; P<0·05). Animals in group F2G2 (r s=0·334; P<0·05) with higher days in milk entered the milking parlour latterly. In all three groups, 68 cows (45·9%) preferred the right side of the milking parlour, 73 the left side (49·3%) and the remaining seven (4·8%) showed no preference. Finally, negative correlations were found between mean entrance order and parity for both groups of Farm 2 (r s=−0·319; P<0·05 and r s=−0·325; P<0·05 for F2G1 and F2G2, respectively). As buffaloes showed higher entrance order consistency and side preference than other domestic ruminants, it is concluded that management practices that disturb their choice should be avoided in order to minimise stress during farming routines.
Serum Concentrations of Hydroxybupropion for Dose Optimization of Depressed Patients Treated With Bupropion

Background: Bupropion is a dopamine and norepinephrine reuptake inhibitor approved for the treatment of depression and smoking cessation. According to the recently published reviews, it is a candidate for therapeutic drug monitoring (TDM) to improve therapeutic outcomes and reduce risks of intolerability or intoxication. In practice, however, the use of TDM is limited due to the chemical instability of bupropion. This investigation sought to determine if the major, active, and chemically stable metabolite 4-hydroxybupropion is a suitable measure to guide antidepressant drug therapy with bupropion. Methods: 4-Hydroxybupropion serum levels were measured using a newly developed and validated high-performance liquid chromatography assay with ultraviolet detection. They correlated with therapeutic effects measured by the clinical global impression scale for improvement. Results: The study included 52 patients (50% women). Patients who were markedly improved according to the clinical global impression scale score had significantly (P = 0.042) higher 4-hydroxybupropion serum levels than those with moderate or minimal improvement (mean ± SD, 1113 ± 576, 825 ± 398, and 475 ± 331 ng/mL, respectively). Analysis of receiver operating characteristics revealed significant predictive properties of 4-hydroxybupropion serum levels (P = 0.002) for marked improvement with a lower threshold level of 858 ng/mL. Under similar mean doses (265 ± 107 versus 239 ± 100 mg, respectively), women attained significantly higher serum levels than men (1050 ± 524 versus 589 ± 352 ng/mL, respectively) and exhibited a better therapeutic effect (P = 0.018). Conclusions: Despite multiple limitations of this naturalistic study, evidence could be given that the measurement of 4-hydroxybupropion in serum is suitable to perform TDM for bupropion. Blood levels should be above 860 ng/mL to attain therapeutic improvement. Potential sex differences in bupropion pharmacokinetics, probably due to differential activities of CYP2B6, should be taken into account when the drug is prescribed.
A study on the texture and microstructure development in extruded AA3003 alloys and the relevant mechanical behaviour

iii characterized as the phenomenon of the grains continuously pinched off during the deformation) is proposed as the mechanism for the case of the simple shear deformation. For the mechanical behaviour of the extruded materials, it was found that the surface layer has little effect on the measured stress-strain curves. However, the surface layer has a large effect on the R-values, i.e. a characteristic value of the material formability. It is suggested that the large R-value difference between the surface layer and the central region of the sample is attributed to the different textures.
Genome-wide association study identified new susceptibility loci for polycystic ovary syndrome.

STUDY QUESTION Are there any novel genetic markers of susceptibility to polycystic ovary syndrome (PCOS)? SUMMARY ANSWER We identified a novel susceptibility locus on chromosome 8q24.2 and several moderately associated loci for PCOS in Korean women. WHAT IS KNOWN ALREADY PCOS is a highly complex disorder with significant contributions from both genetic and environmental factors. Previous genome-wide association studies (GWAS) in the Han Chinese population identified several risk loci for PCOS. However, GWAS studies on PCOS remain very few. The aim of this study was to identify novel markers of susceptibility to PCOS through GWAS. STUDY DESIGN, SIZE, DURATION A two-stage GWAS was conducted. The initial discovery set for GWAS consisted of 976 PCOS cases and 946 controls. The second stage (replication study) included 249 PCOS cases and 778 controls. PARTICIPANTS/MATERIALS, SETTING, METHODS Patients were diagnosed according to the Rotterdam criteria. Genomic DNAs were genotyped using the HumanOmni1-Quad v1 array. In the replication stage, the 21 most promising signals selected from the discovery stage were tested for their association with PCOS. MAIN RESULTS AND THE ROLE OF CHANCE One novel locus with genome-wide significance and seven moderately associated loci for PCOS were identified. The strongest association was on chromosome 8q24.2 (rs10505648, OR = 0.52, P = 5.46 × 10(-8)), and other association signals were located at 4q35.2, 16p13.3, 4p12, 3q26.33, 9q21.32, 11p13 and 1p22 (P = 5.72 × 10(-6)-6.43 × 10(-5)). The strongest signal was located upstream of KHDRBS3, which is associated with telomerase activity, and could drive PCOS and related phenotypes. LIMITATIONS, REASONS FOR CAUTION The limitation of our study is the modest sample size used in the replication cohort. The limited sample size may contribute to a lack of statistical power to detect an association or show a trend in severity. WIDER IMPLICATIONS OF THE FINDINGS Our findings provide new insight into the genetics and biological pathways of PCOS and could contribute to the early diagnosis and prevention of metabolic and reproductive morbidities. STUDY FUNDING/COMPETING INTERESTS This work was supported in part by the grant from the Korea Centers for Disease Control and Prevention (2009-E00591-00). The work was also supported by the Ewha Global Top5 Grant 2013 of Ewha Womans University. None of the authors has any conflict of interest to declare.
An annotation scheme for citation function

We study the interplay of the discourse structure of a scientific argument with formal citations. One subproblem of this is to classify academic citations in scientific articles according to their rhetorical function, e.g., as a rival approach, as a part of the solution, or as a flawed approach that justifies the current research. Here, we introduce our annotation scheme with 12 categories, and present an agreement study.
Inhaled magnesium sulphate in the treatment of bronchial hyperresponsiveness.

UNLABELLED Magnesium sulphate (MgSO(4)) is one of numerous treatment options available during acute asthma exacerbation. A significant, bronchodilating effect of intravenous MgSO(4) has been demonstrated in previous studies, but its inhaled use is less well-defined. OBJECTIVE To investigate the effects of inhaled MgSO(4) alone and in association with a β(2-)agonist in the treatment of bronchial hyperresponsiveness. Methods. We conducted a placebo-controlled, double-blind clinical trial with seventy six adult patients with bronchial hyperresponsiveness. Subjects were randomized into four groups receiving four inhaled products at the end of methacholine (Mech) challenge: NaCl 0.9%, MgSO(4)alone, β(2-)agonist alone, and the combination of MgSO(4)+ β(2-)agonist. Repeated measures of the forced expiratory volume at 1s (FEV(1)) were performed at 0, 5, 10, and 20 minutes after the end of the inhalations. In the MgSO(4)and MgSO(4)+ β(2-)agonist groups, a blood sample was taken before and after inhalation to determine serum magnesium levels. Results. (1) Inhaled MgSO(4) led to a significant improvement of the FEV(1) from the 15(th) minute after its inhalation. (2) β(2-)agonist significantly increased FEV(1) from the 5(th)minute (3) inhaled MgSO(4) + β(2-)agonist led to a significantly greater FEV(1) from the 5(th)minute than inhaled MgSO(4)alone or inhaled β(2-)agonist alone (p<0.05) (4) There is a correlation between low serum magnesium level and the increase in FEV(1)after inhalation of MgSO(4) + β(2-)agonist (p<0.001). Conclusion Inhaled MgSO(4), in combination with β(2-)agonist, appears to have benefits in the treatment of bronchial hyperresponsiveness, especially when associated with hypomagnesemia.
Identical twins reared apart.

Feel lonely? What about reading books? Book is one of the greatest friends to accompany while in your lonely time. When you have no friends and activities somewhere and sometimes, reading book can be a great choice. This is not only for spending the time, it will increase the knowledge. Of course the b=benefits to take will relate to what kind of book that you are reading. And now, we will concern you to try reading identical twins reared apart as one of the reading material to finish quickly.
Physical and chemical characterization of hydrolyzed Napier grass waste for biomass pellets

Utilizing agricultural waste for energy and to conserve the environment has been an active research area recently. In this study, Napier grass waste resulting from its hydrolysis with acids was pelletized and its use was studied as a biomass fuel. An investigation of its physical characteristics, including pellet dimensions and weight, was performed at a laboratory scale. Flat-faced pellets were obtained with enhanced stability necessary for transportation. Chemical characterization of the hydrolyzed waste included determination of its nitrogen, chloride and sulfur content. These values were marginal. After pelletization, experimental determination of its heating values, moisture content and density was examined. It was found that these values exceeded the European standard for biomass pellets. The average of heating value of pelletized biomass was greater than 3500 cal/g. Therefore, a binding material was not necessary. Overall, the investigation revealed that the pellets produced from hydrolyzed Napier grass waste could potentially be exploited as an alternative energy source after some residual chemicals were removed.
New spinfoam vertex for quantum gravity

We introduce a new spinfoam vertex to be used in models of 4d quantum gravity based on SU(2) and SO(4) BF theory plus constraints. It can be seen as the conventional vertex of SU(2) BF theory, the 15j symbol, in a particular basis constructed using SU(2) coherent states. This basis makes the geometric interpretation of the variables transparent: they are the vectors normal to the triangles within each tetrahedron. We study the condition under which these states can be considered semiclassical, and we show that the semiclassical ones dominate the evaluation of quantum correlations. Finally, we describe how the constraints reducing BF to gravity can be directly written in terms of the new variables, and how the semiclassicality of the states might improve understanding the correct way to implement the constraints.
Efficacy of Vagus Nerve Stimulation (VNS) after Multiple Subpial Transections (MST) for Extra-Temporal Seizure Foci

Background: The effect of Vagus nerve stimulation (VNS) therapy following major resective surgeries has been reported. However, the effect of VNS therapy following multiple-subpial-transections (MST) has not been reported. The objective of this paper is to examine the beneficial effect of VNS therapy following MST. Methods: There are 22 patients aged 10 - 55 years. Male/female distribution is 11/11 and follow-up is 24 - 148 months (median of 120 months). Seizure foci were bilateral in 9 patients, multi-lobar (unilateral) in 12 patients and single-lobar in 1 patient. MST was performed over broad areas in and around the seizure foci. VNS implantation was done when the response to MST procedure was poor (1 patients), or there was recurrence of seizures (21 patients). Interval between MST and VNS implanttation varied from one month to three years (median of 2 years). Results: Thirteen patients (59%) are seizure free (Engel’ Class I), 8 (36.5%) have greater than 90% reduction in seizure frequency (Class II), and 1 (4.5%) has between 50% - 90% reduction in seizure frequency (Class III). Conclusion: The results show that VNS therapy produced meaningful improvement in seizure outcome in all patients with extra-temporal seizures that had inadequate response to MST.
Visual spatial attention control in an independent brain-computer interface

This paper presents a novel brain computer interface (BCI) design employing visual evoked potential (VEP) modulations in a paradigm involving no dependency on peripheral muscles or nerves. The system utilizes electrophysiological correlates of visual spatial attention mechanisms, the self-regulation of which is naturally developed through continuous application in everyday life. An interface involving real-time biofeedback is described, demonstrating reduced training time in comparison to existing BCIs based on self-regulation paradigms. Subjects were cued to covertly attend to a sequence of letters superimposed on a flicker stimulus in one visual field while ignoring a similar stimulus of a different flicker frequency in the opposite visual field. Classification of left/right spatial attention is achieved by extracting steady-state visual evoked potentials (SSVEPs) elicited by the stimuli. Six out of eleven physically and neurologically healthy subjects demonstrate reliable control in binary decision-making, achieving at least 75% correct selections in at least one of only five sessions, each of approximately 12-min duration. The highest-performing subject achieved over 90% correct selections in each of four sessions. This independent BCI may provide a new method of real-time interaction for those with little or no peripheral control, with the added advantage of requiring only brief training.