Miracle-dz/UniFAR-FTUs huggingface dataset:
Multichannel active noise equalization of interior noise

An algorithmic variant of the conventional active noise equalizer (ANE), which independently controls some given frequencies of the primary signal, has been developed and extended to the multichannel case. The modified version of the ANE is named common-error multiple-frequency ANE. A detailed analysis of both multichannel equalizers has been carried out. From a convergence analysis in the frequency-domain, the significance of transducer locations in the behavior of a practical system can be predicted through the matrix of secondary path responses at each frequency. The ANEs steady-state transfer functions from the primary input signal to the noise output have also been developed and compared for different parameter settings and for accurate and inaccurate secondary path estimation. Furthermore, the multichannel extension of both equalizers has been implemented in a real-time active system inside a listening room for multifrequency noise. Useful-size zones of equalization have been binaurally measured by using a head and torso simulator. It was found that the common-error multiple-frequency ANE performs better than the conventional equalizer because it achieves a saving in computational complexity and has smaller overshoot. It can also be implemented in a real controller more easily than the conventional ANE and without showing meaningful differences in the practical results provided.
The Braincase and Neurosensory Anatomy of an Early Jurassic Marine Crocodylomorph: Implications for Crocodylian Sinus Evolution and Sensory Transitions

Modern crocodylians are a morphologically conservative group, but extinct relatives (crocodylomorphs) experimented with a wide range of diets, behaviors, and body sizes. Among the most unusual of these fossil groups is the thalattosuchians, an assemblage of marine‐dwellers that transitioned from semiaquatic species (teleosaurids and kin) into purely open‐ocean forms (metriorhynchids) during the Jurassic and Cretaceous Periods (ca 191–125 million years ago). Thalattosuchians can give insight into the origin of modern crocodylian morphologies and how anatomy and behavior change during a major evolutionary transition into a new habitat. Little is known, however, about their brains, sensory systems, cranial sinuses, and vasculature. We here describe the endocranial anatomy of a well‐preserved specimen of the Jurassic semiaquatic teleosaurid Steneosaurus cf. gracilirostris using X‐ray micro‐CT. We find that this teleosaurid still had an ear well attuned to hear on land, but had developed large internal carotid and orbital arteries that likely supplied salt glands, previously thought to be present in only the fully pelagic metriorhynchids. There is no great gulf in endocranial anatomy between this teleosaurid and the metriorhynchids, and some of the features that later permitted metriorhynchids to invade the oceanic realm were apparently first developed in semiaquatic taxa. Compared to modern crocodylians, Steneosaurus cf. gracilirostris has a more limited set of pharyngotympanic sinuses, but it is unclear whether this relates to its aquatic habitat or represents the primitive condition of crocodylomorphs that was later elaborated. Anat Rec, 299:1511–1530, 2016. © 2016 Wiley Periodicals, Inc.
Markers of oxidative stress in dogs with heart failure

We tested the hypothesis that indirect measures of oxidative stress (vitamin E, glutathione peroxidase, and malondialdehyde) differ in dogs in heart failure resulting from either myxomatous mitral valve disease or dilated cardiomyopathy. Dogs were classified according to the International Small Animal Cardiac Health Council (ISACHC) classification. Additionally, the effect of cardiac therapy on oxidative stress parameters and N-terminal pro–B-type natriuretic peptide (NT-proBNP) in advanced stages of congestive heart failure was investigated. There were no significant differences in oxidative stress parameters between healthy dogs and the individual groups of cardiac patients. Significantly lower malondialdehyde (MDA) was observed in the ISACHC II group in comparison to ISACHC groups III and I. A significant positive correlation in treated patients was observed between NT-proBNP and MDA, NT-proBNP and vitamin E, as well as between MDA and vitamin E (and lipid-standardized vitamin E). No significant differences in any of the measured parameters were found between treated and non-treated cardiac patients. Our results suggest an association between MDA (the extent of lipid peroxidation) and NT-proBNP, vitamin E and NT-proBNP, as well as between MDA and vitamin E in treated canine patients. Plasma vitamin E concentration was maintained in all stages of cardiovascular disease in these canine patients.
Tracking Ransomware End-to-end

Ransomware is a type of malware that encrypts the files of infected hosts and demands payment, often in a crypto-currency like Bitcoin. In this paper, we create a measurement framework that we use to perform a large-scale, two-year, end-to-end measurement of ransomware payments, victims, and operators. By combining an array of data sources, including ransomware binaries, seed ransom payments, victim telemetry from infections, and a large database of bitcoin addresses annotated with their owners, we sketch the outlines of this burgeoning ecosystem and associated third-party infrastructure. In particular, we are able to trace the financial transactions, from the acquisition of bitcoins by victims, through the payment of ransoms, to the cash out of bitcoins by the ransomware operators. We find that many ransomware operators cashed out using BTC-e, a now-defunct Bitcoin exchange. In total we are able to track over $16 million USD in likely ransom payments made by 19,750 potential victims during a two-year period. While our study focuses on ransomware, our methods are potentially applicable to other cybercriminal operations that have similarly adopted Bitcoin as their payment channel.
Role of the Dark Triad Traits and Attitude Towards Uncertainty in Decision-Making Strategies in Managers

This article presents the results of an empirical study of decision-making strategies in an uncertain environment as modeled by the Iowa Gambling Task (IGT). The study examines the associations between the Dark Triad traits, tolerance of uncertainty and decision-making effectiveness, measured by the results of strategic choices in a sequential decision-making task with a set goal of obtaining the largest possible profit. The differences in the correlations of the Dark Triad traits with decision-making effectiveness are demonstrated between managers and non-managers. The Dark Triad traits are linked with more effective decision-making strategies only in non-managers. Managers with higher levels of the Dark Triad traits prefer risky and chaotic strategies, especially in the later stages of the decision-making process. Tolerant to uncertainty managers make more effective decisions in the early stages of the prognostic task, these stages are characterized by higher levels of uncertainty and lack of information.
Co-operation between Polymerases and Nucleotide Synthetases in the RNA World

It is believed that life passed through an RNA World stage in which replication was sustained by catalytic RNAs (ribozymes). The two most obvious types of ribozymes are a polymerase, which uses a neighbouring strand as a template to make a complementary sequence to the template, and a nucleotide synthetase, which synthesizes monomers for use by the polymerase. When a chemical source of monomers is available, the polymerase can survive on its own. When the chemical supply of monomers is too low, nucleotide production by the synthetase is essential and the two ribozymes can only survive when they are together. Here we consider a computational model to investigate conditions under which coexistence and cooperation of these two types of ribozymes is possible. The model considers six types of strands: the two functional sequences, the complementary strands to these sequences (which are required as templates), and non-functional mutants of the two sequences (which act as parasites). Strands are distributed on a two-dimensional lattice. Polymerases replicate strands on neighbouring sites and synthetases produce monomers that diffuse in the local neighbourhood. We show that coexistence of unlinked polymerases and synthetases is possible in this spatial model under conditions in which neither sequence could survive alone; hence, there is a selective force for increasing complexity. Coexistence is dependent on the relative lengths of the two functional strands, the strand diffusion rate, the monomer diffusion rate, and the rate of deleterious mutations. The sensitivity of this two-ribozyme system suggests that evolution of a system of many types of ribozymes would be difficult in a purely spatial model with unlinked genes. We therefore speculate that linkage of genes onto mini-chromosomes and encapsulation of strands in protocells would have been important fairly early in the history of life as a means of enabling more complex systems to evolve.
Metabolic Therapy with Deanna Protocol Supplementation Delays Disease Progression and Extends Survival in Amyotrophic Lateral Sclerosis (ALS) Mouse Model

Amyotrophic Lateral Sclerosis (ALS), also known as Lou Gehrig’s disease, is a neurodegenerative disorder of motor neurons causing progressive muscle weakness, paralysis, and eventual death from respiratory failure. There is currently no cure or effective treatment for ALS. Besides motor neuron degeneration, ALS is associated with impaired energy metabolism, which is pathophysiologically linked to mitochondrial dysfunction and glutamate excitotoxicity. The Deanna Protocol (DP) is a metabolic therapy that has been reported to alleviate symptoms in patients with ALS. In this study we hypothesized that alternative fuels in the form of TCA cycle intermediates, specifically arginine-alpha-ketoglutarate (AAKG), the main ingredient of the DP, and the ketogenic diet (KD), would increase motor function and survival in a mouse model of ALS (SOD1-G93A). ALS mice were fed standard rodent diet (SD), KD, or either diets containing a metabolic therapy of the primary ingredients of the DP consisting of AAKG, gamma-aminobutyric acid, Coenzyme Q10, and medium chain triglyceride high in caprylic triglyceride. Assessment of ALS-like pathology was performed using a pre-defined criteria for neurological score, accelerated rotarod test, paw grip endurance test, and grip strength test. Blood glucose, blood beta-hydroxybutyrate, and body weight were also monitored. SD+DP-fed mice exhibited improved neurological score from age 116 to 136 days compared to control mice. KD-fed mice exhibited better motor performance on all motor function tests at 15 and 16 weeks of age compared to controls. SD+DP and KD+DP therapies significantly extended survival time of SOD1-G93A mice by 7.5% (p = 0.001) and 4.2% (p = 0.006), respectively. Sixty-three percent of mice in the KD+DP and 72.7% of the SD+DP group lived past 125 days, while only 9% of the control animals survived past that point. Targeting energy metabolism with metabolic therapy produces a therapeutic effect in ALS mice which may prolong survival and quality of life in ALS patients.
Influence of biomass burning from South Asia at a high-altitude mountain receptor site in China

Abstract. Highly time-resolved in situ measurements of airborne particles were conducted at Mt. Yulong (3410 m above sea level) on the southeastern edge of the Tibetan Plateau in China from 22 March to 14 April 2015. The detailed chemical composition was measured by a high-resolution time-of-flight aerosol mass spectrometer together with other online instruments. The average mass concentration of the submicron particles (PM1) was 5.7 ± 5.4 µg m−3 during the field campaign, ranging from 0.1 up to 33.3 µg m−3. Organic aerosol (OA) was the dominant component in PM1, with a fraction of 68 %. Three OA factors, i.e., biomass burning organic aerosol (BBOA), biomass-burning-influenced oxygenated organic aerosol (OOA-BB) and oxygenated organic aerosol (OOA), were resolved using positive matrix factorization analysis. The two oxygenated OA factors accounted for 87 % of the total OA mass. Three biomass burning events were identified by examining the enhancement of black carbon concentrations and the f60 (the ratio of the signal at m∕z 60 from the mass spectrum to the total signal of OA). Back trajectories of air masses and satellite fire map data were integrated to identify the biomass burning locations and pollutant transport. The western air masses from South Asia with active biomass burning activities transported large amounts of air pollutants, resulting in elevated organic concentrations up to 4-fold higher than those of the background conditions. This study at Mt. Yulong characterizes the tropospheric background aerosols of the Tibetan Plateau during pre-monsoon season and provides clear evidence that the southeastern edge of the Tibetan Plateau was affected by the transport of anthropogenic aerosols from South Asia.
Total neoadjuvant therapy for rectal cancer: An emerging option

The treatment of locally advanced rectal cancer (LARC) has benefited from improved surgical techniques and from the implementation of neoadjuvant chemoradiotherapy (CRT), which have markedly decreased the rates of local recurrence. However, distant metastatic disease remains the most significant cause of death for these patients. Although adjuvant chemotherapy (ChT) after neoadjuvant CRT and definitive surgery is commonly recommended, the value of adjuvant systemic therapy remains less clear. Trials evaluating adjuvant ChT for rectal cancer have been handicapped by poor compliance rates and inconsistent survival results. Shifting systemic therapy delivery to the neoadjuvant setting has the promise to improve compliance rates, reduce toxicity, and decrease distant relapse rates. Recently, multiple prospective trials have reported on the use of total neoadjuvant therapy (TNT) for patients with LARC, incorporating both ChT and CRT in the neoadjuvant setting. Here, the authors review the promising results from those trials. Because the studies have largely focused on pathologic outcomes (primarily pathologic complete response rates), ongoing phase 2 and 3 trials are now underway assessing the long‐term disease‐related outcomes with TNT. In addition to improving survival, TNT has the potential to increase the pool of patients with LARC who are eligible for organ preservation, which is also being evaluated. Cancer 2017;123:1497–1506. © 2017 American Cancer Society.
Liquid methionine as a drinking water supplement for broiler chicks.

Three experiments were conducted to study the effect of a liquid methionine source supplied through the water on chick performance. Methionine at . 025, . 05, and . 075% (Experiment 3, only) from the liquid source were added to the drinking water and compared with . 05 and . 075% (Experiment 2 and 3) dry methionine supplementation in a methionine-deficient basal. A dry DL-methionine was used for diet supplementation in Experiments 1 and 2, and both liquid and dry sources were used in Experiment 3. Day-old (Cobb) feather-sexed broiler chicks received these treatments for 3-week periods. Mortality was not significantly altered by any of the treatments. In two of the three experiments neither feed nor water intake was significantly affected by treatment. In Experiment 2, control birds consumed significantly less feed than other groups, and daily water intake of birds that received . 05% supplemental feed methionine was elevated above that of other regimens. Fecal moisture and fecal sodium levels were not elevated above those measured from the unsupplemented basal. In all three studies comparable levels of methionine from feed or water supported equivalent body weights. Within the limits of these tests, liquid DL-methionine provided in the drinking water was effectively assimilated by broiler chicks and increased total methionine intake, which increased growth.
Evolution of telomere maintenance and tumour suppressor mechanisms across mammals

Mammalian species differ dramatically in telomere biology. Species larger than 5–10 kg repress somatic telomerase activity and have shorter telomeres, leading to replicative senescence. It has been proposed that evolution of replicative senescence in large-bodied species is an anti-tumour mechanism counteracting increased risk of cancer due to increased cell numbers. By contrast, small-bodied species express high telomerase activity and have longer telomeres. To counteract cancer risk due to longer lifespan, long-lived small-bodied species evolved additional telomere-independent tumour suppressor mechanisms. Here, we tested the connection between telomere biology and tumorigenesis by analysing the propensity of fibroblasts from 18 rodent species to form tumours. We found a negative correlation between species lifespan and anchorage-independent growth. Small-bodied species required inactivation of Rb and/or p53 and expression of oncogenic H-Ras to form tumours. Large-bodied species displayed a continuum of phenotypes requiring additional genetic ‘hits’ for malignant transformation. Based on these data we refine the model of the evolution of tumour suppressor mechanisms and telomeres. We propose that two different strategies evolved in small and large species because small-bodied species cannot tolerate small tumours that form prior to activation of the telomere barrier, and must instead use telomere-independent strategies that act earlier, at the hyperplasia stage. This article is part of the theme issue ‘Understanding diversity in telomere dynamics’.
Traveling Wave Solutions for Systems of ODEs on a Two-Dimensional Spatial Lattice

We consider innite systems of ODEs on the two-dimensional integer lattice, given by a bistable scalar ODE at each point, with a nearest neighbor coupling between lattice points. For a class of ideal nonlinearities, we obtain traveling wave solutions in each direction e i , and we explore the relation between the wave speed c, the angle , and the detuning parameter a of the nonlinearity. Of particular interest is the phenomenon of \propagation failure," and we study how the critical value a = a() depends on , where a() is dened as the value of the parameter a at which propagation failure (that is, wave speed c = 0) occurs. We show that a :R! R is continuous at each point where tan is irrational, and is discontinuous where tan is rational or innite.
Exercise Intervention in Pediatric Patients with Solid Tumors: The Physical Activity in Pediatric Cancer Trial

Introduction The randomized controlled trial “Physical Activity in Pediatric Cancer” determined the effects of an inhospital exercise intervention combining aerobic and muscle strength training on pediatric cancer patients with solid tumors undergoing neoadjuvant chemotherapy. Methods Participants were allocated to an exercise (n = 24, 17 boys; mean ± SEM age, 10 ± 1 yr) or control group (n = 25, 18 boys; 11 ± 1 yr). Training included three sessions per week for 19 ± 2 wk. Participants were assessed at treatment initiation, termination, and 2 months after end treatment. The primary endpoint was muscle strength (as assessed by upper and lower-body five-repetition-maximum tests). Secondary endpoints included cardiorespiratory fitness, functional capacity during daily life activities, physical activity, body mass and body mass index, and quality of life. Results Most sessions were performed in the hospital’s gymnasium. Adherence to the program averaged 68% ± 4% and no major adverse events or health issues were noted. A significant interaction (group–time) effect was found for all five-repetition maximum tests (leg/bench press and lateral row; all P < 0.001). Performance significantly increased after training (leg press: 40% [95% confidence interval [CI], 15–41 kg); bench press: 24% [95% CI, 6–14 kg]; lateral row 25% [95% CI, 6–15 kg]), whereas an opposite trend was found in controls. Two-month post values tended to be higher than baseline for leg (P = 0.017) and bench press (P = 0.014). In contrast, no significant interaction effect was found for any of the secondary endpoints. Conclusion An inhospital exercise program for pediatric cancer patients with solid tumors undergoing neoadjuvant treatment increases muscle strength despite the aggressiveness of such therapy.
Effects of dietary fat on feed efficiency, reproductive performance, and in vitro lipogenesis by the turkey hen.

Two 16-week feeding trials were conducted with Large White turkey hens to determine the effect of graded energy levels (as fat-6, 18, 30, and 42% substituted isocalorically for corn meal) on energy efficiency, reproductive performance, lipogenic enzyme activity, and in vitro lipogenesis. A constant calorie: gram-protein ratio (17:1) was maintained for all dietary treatments. Also, other components of the diets were adjusted to maintain constant energy-to-nutrient ratios. Additional fat increased (P less than .05) energy utilization but had no effect on reproductive performance. Additional fat calories decreased (P less than .05) malic enzyme, isocitrate dehydrogenase, and fatty acid synthetase activities; however, fatty acid synthetase activity was the most responsive of the three enzymes to 42% metabolizable energy as fat. Liver lipid content was also decreased (P less than .05) by additional fat calories. In vitro lipogenesis (fatty synthesis from 10 mM (1-14C) sodium acetate) was also decreased (P less than .01) by additional dietary fat.
A new stage of the nutrition transition in China

Abstract Objective: To fully explore the long-term shifts in the nutrition transition and the full implications of these changes in the Chinese diet. Design: A descriptive, population-based study. Setting: Data come from nationally representative surveys: the China Health and Nutrition Survey (1989–1997), the China National Nutrition Survey (1982 and 1992), the annual household consumption surveys of the State Statistical Bureau, and the Annual Death Report of China. Results: During the first part of the major economic transformation in China (before 1985), cereal intake increased but decreased thereafter. There was also a long-term reduction of vegetable consumption that has now stabilised. Intake of animal foods increased slowly before 1979 and more quickly after the economic reforms occurred. While the total energy intake of residents has decreased, as has energy expenditure, large changes in the composition of energy have occurred. The overall proportion of energy from fat increased quickly, reaching an overall average of 27.3% and 32.8% for urban residents in 1997. Over a third of all Chinese adults and 60.1% of those in urban areas consumed over 30% of their energy from fat in 1997. Large shifts towards increased inactivity at work and leisure occurred. These changes are linked with rapid increases of overweight, obesity and diet-related non-communicable diseases (DRNCDs) as well as total mortality for urban residents. Conclusions: The long-term trend is a shift towards a high-fat, high-energy-density and low-fibre diet. The Chinese have entered a new stage of the nutrition transition.