Miracle-dz/UniFAR-FTUs huggingface dataset:
DIAGNOSTIC VALUE OF RK39 DIPSTICK IN ZOONOTIC VISCERAL LEISHMANIASIS IN TURKEY

K39 is a repetitive immunodominant epitope in a kinesin-related protein expressed predominantly in the amastigotes of visceral Leishmania spp. Enzyme immunoassays of patient's sera with recombinant K39 (rK39) proved to be highly specific and sensitive for diagnosis of active visceral leishmaniasis (VL, kala-azar). The same assays in dipstick format were also found effective for diagnosis of both human VL (HVL) and canine VL (CanVL) in most endemic areas of these diseases. Fifty-eight human patients and 22 dogs, clinically suspected of kala-azar, were screened with rK39 dipstick in comparison with the conventional methods of diagnosis, i.e., microscopic examinations of bone marrow and lymph node aspirates and immunofluorescent antibody tests (IFAT), respectively. Sixteen patients and 12 dogs were found to be rK39 dipstick positive. The results were corroborated with those of parasitological examinations, except 1, rK39-positive but smear-negative, case in each group. IFAT of the 2 discordant cases gave positive results. The rK39 dipstick is thus reliable for diagnosis of both HVL and canVL cases in Turkey.
THE ROLE OF TEMPTATION IN EXPLAINING CONSUMPTION AND INVESTMENT CHOICE

I simulate a life-cycle model with preferences described by a utility function a la Gul and Pesendorfer (2001). I show that temptation to consume contributes to explain the saving, retirement consumption, and asset allocation puzzles. I perform two analyses, excluding or including Social Security protection, separately for the US and Italy. The pension replacement rate is endogenous in the model and varies with income realizations. The results also show that the optimal behavior differs remarkably between the two countries when Social Security is considered. In particular, the more generous Italian system depresses savings and investments of more tempted individuals.
Creating colored pencil style images by drawing strokes based on boundaries of regions

A lot of non-photorealistic rendering methods have been proposed for creating an artistic image from an image. In this paper, we propose a method for creating colored pencil style images. The feature of colored pencil drawings is that, though colored pencil drawings are drawn with limited number of colors of pencils, we can express a lot of colors and gentle textures by changing the strengths when drawing strokes and by overlapping strokes of different colors. In order to realize this feature, we determine which colors of pencils to use and how deep to push the pencils (equivalent to the strength when drawing strokes), then draw several types of strokes, such as strokes for outlines, basecoats, and shading, allowing the strokes to overlap each other. When we create strokes for shading, we make their directions to align along the boundaries of regions, resulting in images that are more like drawings made by human.
Peripheral Arterial Disease among Adult Diabetic Patients Attending a Large Outpatient Diabetic Clinic at a National Referral Hospital in Uganda: A Descriptive Cross Sectional Study

Background Peripheral arterial disease (PAD) is one of the recognised diabetic macro vascular complications. It is a marker of generalised systemic atherosclerosis and is closely associated with symptomatic coronary and cerebrovascular disease, hence significant morbidity and mortality. Among African adult diabetic populations, screening and diagnosis of PAD is frequently suboptimal. The aim of this study was to determine the prevalence and associated clinical factors of PAD in adult ambulatory diabetic patients attending the outpatient diabetic clinic of Mulago national referral and teaching hospital, Kampala Uganda. Methods In this descriptive cross sectional study, 146 ambulatory adult diabetic patients were studied. Information about their socio-demographic and clinical characteristics, fasting lipid profile status, blood pressure, glycated haemoglobin (HbA1c) levels and presence of albuminuria was collected using a pre tested questionnaire. Measurement of ankle brachial index (ABI) to assess for PAD, defined as a ratio less than 0.9 was performed using a portable 5–10 MHz Doppler device. Clinical factors associated with PAD were determined by comparing specific selected characteristics in patients with PAD and those without. Results The mean age/standard deviation of the study participants was 53.9/12.4 years with a male predominance (75, 51.4%). PAD was prevalent in 57 (39%) study participants. Of these, 34 (59.6%) had symptomatic PAD. The noted clinical factors associated with PAD in this study population were presence of symptoms of intermittent claudication and microalbuminuria. Conclusions This study documents a high prevalence of PAD among adult ambulatory Ugandan diabetic patients. Aggressive screening for PAD using ABI measurement in adult diabetic patients should be emphasised in Uganda especially in the presence of symptoms of intermittent claudication and microalbuminuria.
Genes Involved in Systemic and Arterial Bed Dependent Atherosclerosis - Tampere Vascular Study

Background Atherosclerosis is a complex disease with hundreds of genes influencing its progression. In addition, the phenotype of the disease varies significantly depending on the arterial bed. Methodology/Principal Findings We characterized the genes generally involved in human advanced atherosclerotic (AHA type V–VI) plaques in carotid and femoral arteries as well as aortas from 24 subjects of Tampere Vascular study and compared the results to non-atherosclerotic internal thoracic arteries (n=6) using genome-wide expression array and QRT-PCR. In addition we determined genes that were typical for each arterial plaque studied. To gain a comprehensive insight into the pathologic processes in the plaques we also analyzed pathways and gene sets dysregulated in this disease using gene set enrichment analysis (GSEA). According to the selection criteria used (>3.0 fold change and p-value <0.05), 235 genes were up-regulated and 68 genes down-regulated in the carotid plaques, 242 genes up-regulated and 116 down-regulated in the femoral plaques and 256 genes up-regulated and 49 genes down-regulated in the aortic plaques. Nine genes were found to be specifically induced predominantly in aortic plaques, e.g., lactoferrin, and three genes in femoral plaques, e.g., chondroadherin, whereas no gene was found to be specific for carotid plaques. In pathway analysis, a total of 28 pathways or gene sets were found to be significantly dysregulated in atherosclerotic plaques (false discovery rate [FDR] <0.25). Conclusions This study describes comprehensively the gene expression changes that generally prevail in human atherosclerotic plaques. In addition, site specific genes induced only in femoral or aortic plaques were found, reflecting that atherosclerotic process has unique features in different vascular beds.
Herding Cats : The Lawyer Personality Revealed

These “lawyer personality traits” have broad implications for the management of lawyers, the cultivation of rainmakers, the retention of associates and a range of other critical issues in the day-to-day practice of law. In this article, I will explain how lawyers differ from the lay public—in some cases significantly—and how rainmakers differ from other lawyers. I’ll then discuss how such personality data can be used to improve hiring and management.
Morphological variability of the trabecular meshwork in glaucoma patients: implications for non-perforating glaucoma surgery

BACKGROUND/AIMS Morphological variability of the trabecular meshwork could be of considerable importance for the proper intraoperative outcome of non-perforating antiglaucomatous surgery, such as deep sclerectomy and viscocanalostomy. The aim of this study was therefore to assess qualitative and quantitative characteristics of the trabecular meshwork in glaucoma patients undergoing trabeculectomy. METHODS Trabeculectomy specimens from 177 glaucoma patients were prepared for light microscopy; 100 specimens were found to be suitable for qualitative assessment and quantitative computerised image analysis; measurements were taken of the meridional diameter of Schlemm's canal as well as the thickness of the trabecular meshwork at different positions. RESULTS The mean meridional diameter of Schlemm's canal was 290 μm with the smallest values in the young patients with infantile and secondary glaucomas. the thickness of the trabecular meshwork ranged between 50–70 μm in the anterior region and between 100–130 μm for the posterior portion. The thickness of the anterior meshwork significantly decreased with age. The pigmentation of excised trabecular meshwork was found to be weak or even lacking in 68 patients. In 20 glaucoma patients the uveal meshwork was covered by an endothelial layer. CONCLUSIONS From the morphological point of view the risk of inadvertent perforation during deep sclerectomy in older, white glaucoma patients should be taken into account even by an experienced surgeon, because the anterior meshwork in these cases is very thin and trabecular pigmentation that can be used as a topographic landmark is often lacking. The functional success of non-perforating glaucoma surgery in many patients may be limited by endothelial covering of the trabecular meshwork.
Testing Merton's Model for Credit Spreads on Zero-Coupon Bonds

Structural models for valuing corporate bonds (beginning with Merton (1974)) have been criticised for giving spreads which are (a) too small and (b) have a term structure in which spreads diminish with extra time to maturity. Empirical tests of models are hampered by the complexity of real-world bonds, which have coupons, calls and sinking funds, and also by the complicated and changing capital structures adopted by companies. This paper exploits a new database of zero-coupon bonds issued by closed-end funds in the UK. These companies have very simple capital structures and transparent values for both assets and liabilities. Between 20 and 78 bonds are observable monthly over the period February 1992 to April 2001. Counter to previous research, we find that model and market spreads are on average of similar magnitude. Similar to previous research, market spreads are high (relative to model spreads) for bonds which have low risk and for bonds which are near to maturity. While the observed term-structure of credit spreads is upward-sloping, this may be explained by a predictable drift in leverage over time. On the whole, the results are surprisingly supportive of Merton’s model and suggest that it is important to allow for expected changes in leverage when computing credit spreads.
Solving a Realistic Location Area Problem Using SUMATRA Networks with the Scatter Search Algorithm

This paper presents a new approach based on the Scatter Search (SS) algorithm applied to the Location Management problem using the Location Area (LA) scheme. The LA scheme is used to achieve the best configuration of the network partitioning, into groups of cells (location areas), that minimizes the costs involved. In this work we execute five distinct experiments with the aim of setting the best values for the Scatter Search parameters, using test networks generated with realistic data [1]. We also want to compare the results obtained by this new approach with those achieved through classical strategies, other algorithms from our previous work and also by other authors. The simulation results show that this SS based approach is very encouraging.
Decreased working memory and processing speed mediate cognitive impairment in geriatric depression

Background. While neuropsychological dysfunction is common in geriatric depression, not all aspects of cognition are equally affected. It has been suggested that depressed patients are impaired only in tasks that make heavy demands on processing resources and that a resource decrement therefore underlies the neuropsychological decrements seen in geriatric depression. The present study examined whether processing resources in the form of working memory and information processing speed are decreased in depression and whether a decrease in these resources actually mediates neuropsychological impairment. Methods. Measures of processing resources were administered to elderly depressed patients prior to treatment and to age-matched controls. Patients whose depression remitted were retested as were the controls. Subjects also received neuropsychological tests of episodic memory and visuospatial performance. Results. Depressed patients performed significantly worse on measures of both processing speed and working memory. While performance on these measures improved in patients whose depression remitted, the amount of improvement was no greater than that seen in the controls with repeat testing. Hierarchical regression analyses showed that depression explained a significant amount of variance on the neuropsychological tasks. However, if the variance associated with processing resources was removed first, depression no longer accounted for a significant amount of neuropsychological variance. Conclusions. Processing resources are decreased in elderly depressed patients and this decrease in resources appears to mediate impairments in several areas of neuropsychological functioning including episodic memory and visuospatial performance. The resource decrement persists after remission of the depression and thus may be a trait marker of geriatric depression.
Renal angiotensin II type 1 receptor expression and associated hypertension in rats with minimal SHR nuclear genome

Angiotensin II (AII) has been linked as a causal factor in several experimental models of hypertension (HT) including Okamoto spontaneously hypertensive rats (SHR). The transmission and expression of AII type 1 receptors (AT1r) in SHR and the development of genetic HT remain unknown. It is hypothesized that tissue‐specific expression of renin–angiotensin system (RAS) genes derived from SHR are linked to HT in offspring of SHR crossed with Brown Norway (BN) rats. Hypertensive female progeny of BN/SHR matings was backcrossed with founder BN males to generate the F1 and five backcross generations (BN/SHR‐mtSHR). Progeny were phenotyped according to normotension (NT: systolic arterial pressure [SAP] ≤ 124 mmHg), borderline hypertension (BHT: 124 ≤ SAP < 145 mmHg), and HT (SAP ≥ 145 mmHg). Six generations produced more HT (n = 88; 46%) than NT (n = 21; 11%) offspring. The mRNA expression of the RAS was evaluated in NT (n = 20) and HT (n = 20) BN/SHR‐mtSHR across several generations. Quantitative real‐time polymerase chain reaction analysis of kidney tissue showed increased expression of AII, type 1 receptors (Agtr1a) (~2.5‐fold) in HT versus NT rats, while other members of both the renal and systemic RAS pathway were not different. Western blot analysis from kidney homogenates showed that AT1r protein levels were higher (P < 0.05) in backcross generation 3 (BC3) HT versus NT rats. Evaluation of SAP as a function of AT1r expression by linear regression indicated positive correlation (P < 0.05) in kidney of BC3 BN/SHR‐mtSHR rats. Thus, elevated kidney AT1r expression may be involved in the development of HT in BN/SHR‐mtSHR rats.
Choking under pressure: the neuropsychological mechanisms of incentive-induced performance decrements

In contrast to the assumption of efficiency wage models, which state that wage incentives should be positively correlated with productivity, high incentives may produce performance decrements in real life scenarios. Such a “choking under pressure” phenomenon exemplifies how psychological stress can profoundly shape human behavior, for good or for bad. Previous theories suggest that individual choking under pressure because that high pressure may distract individuals’ attention away from the task (the distraction account), raise the attention paid to step-by-step skill processes (the explicit monitoring account), or elevate the arousal in general (the over-arousal account). Recent neuroimaging studies have shown that several brain regions implicated in motivation and top-down control of attention also play a key role in stress-induced choking, supporting for the over-arousal and distraction theories of choking. This review aims to identify psychological factors that determine choking and the neural underpinnings of these processes. Insights into how incentives influence performance may aid engineering training regimens and interventions that equip individuals to better handle high-stakes-induced psychological stress, and to thrive under stress.
A Syntax-Driven Bracketing Model for Phrase-Based Translation

Syntactic analysis influences the way in which the source sentence is translated. Previous efforts add syntactic constraints to phrase-based translation by directly rewarding/punishing a hypothesis whenever it matches/violates source-side constituents. We present a new model that automatically learns syntactic constraints, including but not limited to constituent matching/violation, from training corpus. The model brackets a source phrase as to whether it satisfies the learnt syntactic constraints. The bracketed phrases are then translated as a whole unit by the decoder. Experimental results and analysis show that the new model outperforms other previous methods and achieves a substantial improvement over the baseline which is not syntactically informed.
SansText: Classifying temporal topic dynamics of Twitter cascades without tweet text

Understanding the dynamics of cascades in Twitter is an important modeling problem with multiple applications like viral marketing and the detection and forecasting of emerging events. Key hashtags rise in popularity to a peak and fall, with profiles characteristic to the specific topical area of the hashtag. Traditional text-based classification approaches are inadequate as new hashtags get created dynamically and because social media vocabulary evolves. We demonstrate a text-free approach SansText to classify emerging cascades by modeling the phenomenological patterns of rise and fall. We illustrate the utility of this approach over several specific event classes as well as more general topics in a collection of more than 2 million tweets from multiple countries of Latin America.
Sonification Aesthetics and Listening for Network Situational Awareness

This paper looks at the problem of using sonification to enable network administrators to maintaining situational awareness about their network environment. Network environments generate a lot of data and the need for continuous monitoring means that sonification systems must be designed in such a way as to maximise acceptance while minimising annoyance and listener fatigue. It will be argued that solutions based on the concept of the soundscape offer an ecological advantage over other sonification designs.
Diverging Drought Resistance of Scots Pine Provenances Revealed by Infrared Thermography

With recent climate changes, Scots pine (Pinus sylvestris L.) forests have been affected by die-off events. Assisted migration of adapted provenances mitigates drought impacts and promotes forest regeneration. Although suitable provenances are difficult to identify by traditional ecophysiological techniques, which are time consuming and invasive, plant water status can be easily assessed by infrared thermography. Thus, we examined the stress responses of 2-year-old potted Scots pine seedlings from six provenances (Bulgaria, France, Germany, Italy, Poland, and Spain) based on two thermal indices (crop water stress index and stomatal conductance index). Both indices were derived from infrared images during a 6-week drought/control treatment in a greenhouse in the summer of 2013. The pines were monitored during the stress and subsequent recovery period. After controlling for fluctuating environmental conditions, soil moisture or treatment-specific water supply was the most important driver of drought stress. The stress magnitude and response to soil water deficit depended on provenance. Under moderate drought conditions, pines from western and eastern Mediterranean provenances (Bulgaria, France, and Spain) expressed lower stress levels than those from both continental provenances (Germany and Poland). Moreover, pines from continental provenances were less resilient (showed less recovery after the stress period) than Mediterranean pines. Under extreme drought, all provenances were equally stressed with almost no significant differences in their thermal indices. Provenance-specific differences in drought resistance, which are associated with factors such as summer precipitation at the origin of Scots pine seedlings, may offer promising tracks of adaptation to future drought risks.
Lentiviral miR30-based RNA Interference against Heparanase Suppresses Melanoma Metastasis with Lower Liver and Lung Toxicity

Aim: To construct short hairpin RNAs (shRNAs) and miR30-based shRNAs against heparanase (HPSE) to compare their safety and their effects on HPSE down-modulation in vitro and in vivo to develop a more ideal therapeutic RNA interference (RNAi) vector targeting HPSE. Methods: First, we constructed shRNAs and miR30-based shRNAs against HPSE (HPSE-shRNAs and HPSE-miRNAs) and packed them into lentiviral vectors. Next, we observed the effects of the shRNAs on knockdown for HPSE expression, adhesion, migration and invasion abilities in human malignant melanoma A375 cells in vitro. Furthermore, we compared the effects of the shRNAs on melanoma growth, metastasis and safety in xenograft models. Results: Our data showed that these artificial miRNAs targeting HPSE could be effective RNAi agents mediated by Pol II promoters in vitro and in vivo, although these miRNAs were not more potent than the HPSE-shRNAs. It was noted that obvious lung injuries, rarely revealed previously, as well as hepatotoxicity could be caused by lentivirus-mediated shRNAs (LV shRNAs) rather than lentivirus-mediated miRNAs (LV miRNAs) in vivo. Furthermore, enhanced expression of pro-inflammatory cytokines IL-6 and TGF-β1 and endogenous mmu-miR-21a-5p were detected in lung tissues of shRNAs groups, whereas the expression of mmu-let-7a-5p, mmu-let-7b-5p and mmu-let-7c-5p were down-regulated. Conclusion: These findings suggest that artificial miRNAs display an improved safety profile of lowered lung injury or hepatotoxicity relative to shRNAs in vivo. The mechanism of lung injuries caused by shRNAs may be correlated with changes of endogenous miRNAs in the lung. Our data here increase the flexibility of a miRNA-based RNAi system for functional genomic and gene therapy applications.
POSITIVE LINE BUNDLES ON ARITHMETIC VARIETIES

p 5~~~~~~~~~~~~~~~~~~u integers is defined to count the volume of the lattice I(L? n) of integral sections in the space J7(Lon) of real sections with supremum norm. We want to prove that the leading term of this Hilbert function as n -f oo is given in terms of the height of X in as ? 1. This is known as a theorem of Gillet and Soule [GS2] if X has a regular generic fiber. Beside this known result, our proof uses Hironaka's theorem on resolutions of singularities and Minkowski's theorem on successive minima. By Hironaka's theorem, we may construct