Miracle-dz/UniFAR-FTUs huggingface dataset:
L OSS-AWARE W EIGHT Q UANTIZATION OF D EEP N ET-WORKS

The huge size of deep networks hinders their use in small computing devices. In this paper, we consider compressing the network by weight quantization. We extend a recently proposed loss-aware weight binarization scheme to ternarization, with possibly different scaling parameters for the positive and negative weights, and m-bit (where m > 2) quantization. Experiments on feedforward and recurrent neural networks show that the proposed scheme outperforms state-of-the-art weight quantization algorithms, and is as accurate (or even more accurate) than the full-precision network.
Individual Reaction to Past Performance Sequences: Evidence from a Real Marketplace

We use novel data on individual activity in a sports betting market to study the effect of past performance sequences on individual behavior in a real market. The revelation of fundamental values in this market enables us to disentangle whether behavior is caused by sentiment or by superior information about market mispricings, hence to cleanly test in a real setting two sentiment-based theories of momentum and reversals — the regime-shifting model of Barberis, Shleifer, and Vishny (1998) and the gambler's/hot-hand fallacy model of Rabin (2002). Furthermore, our long panel allows us to calculate the proportions of individuals who exhibit each type of behavior. We find that i) three quarters of individuals exhibit trend-chasing behavior; ii) seven times as many individuals exhibit behavior consistent with Barberis, Shleifer, and Vishny (1998) as exhibit behavior consistent with Rabin (2002); and iii) no individuals earn superior returns from momentum trading.
Malleilactone Is a Burkholderia pseudomallei Virulence Factor Regulated by Antibiotics and Quorum Sensing

ABSTRACT Burkholderia pseudomallei, the causative agent of melioidosis, encodes almost a dozen predicted polyketide (PK) biosynthetic gene clusters. Many of these are regulated by LuxR-I-type acyl-homoserine (AHL) quorum-sensing systems. One of the PK gene clusters, the mal gene cluster, is conserved in the close relative Burkholderia thailandensis. The B. thailandensis mal genes code for the cytotoxin malleilactone and are regulated by a genetically linked LuxR-type transcription factor, MalR. Although AHLs typically interact with LuxR-type proteins to modulate gene transcription, the B. thailandensis MalR does not appear to be an AHL receptor. Here, we characterize the mal genes and MalR in B. pseudomallei. We use chemical analyses to demonstrate that the B. pseudomallei mal genes code for malleilactone. Our results show that MalR and the mal genes contribute to the ability of B. pseudomallei to kill Caenorhabditis elegans. In B. thailandensis, antibiotics like trimethoprim can activate MalR by driving transcription of the mal genes, and we demonstrate that some of the same antibiotics induce expression of B. pseudomallei malR. We also demonstrate that B. pseudomallei MalR does not respond directly to AHLs. Our results suggest that MalR is indirectly repressed by AHLs, possibly through a repressor, ScmR. We further show that malleilactone is a B. pseudomallei virulence factor and provide the foundation for understanding how malleilactone contributes to the pathology of melioidosis infections. IMPORTANCE Many bacterially produced polyketides are cytotoxic to mammalian cells and are potentially important contributors to pathogenesis during infection. We are interested in the polyketide gene clusters present in Burkholderia pseudomallei, which causes the often-fatal human disease melioidosis. Using knowledge gained by studies in the close relative Burkholderia thailandensis, we show that one of the B. pseudomallei polyketide biosynthetic clusters produces a cytotoxic polyketide, malleilactone. Malleilactone contributes to B. pseudomallei virulence in a Caenorhabditis elegans infection model and is regulated by an orphan LuxR family quorum-sensing transcription factor, MalR. Our studies demonstrate that malleilactone biosynthesis or MalR could be new targets for developing therapeutics to treat melioidosis.
Molecular detection and phylogenetic analysis of human parechovirus in individuals with acute diarrhea and healthy controls in Guangzhou, China

Human parechoviruses (HPeVs) are prevalent in young children; however, their effects are incompletely understood. We investigated the prevalence, genotype distribution, and phylogeny of HPeVs in individuals with diarrhea (n = 430) and healthy controls (n = 93) by the analysis of stool specimens collected from July 2013 to December 2014; 51 (11.86%) and 6 (6.45%) specimens were HPeV positive, respectively. HPeV1A occurred in 28 (6.51%) and 6 (6.45%) individuals with diarrhea and controls, respectively, whereas HPeV1B (3.95%), HPeV3 (0.23%), HPeV4 (0.70%), and HPeV14 (a rare genotype, 0.47%) were only detected in individuals with diarrhea. There was no significant difference in the rate of HPeV detection between the 2 groups; however, the mean age of HPeV infection was significantly lower in males. We conclude that HPeVs may be opportunistic pathogens associated with acute diarrhea. Immunocompromised individuals, such as children aged under 2 years and the elderly, could be vulnerable to HPeV infections.
Counterproductive punishment: How prison gangs undermine state authority

State efforts to provide law and order can be counterproductive: mass-incarceration policies, while incapacitating and deterring individual criminals, can simultaneously strengthen collective criminal networks. Sophisticated prison gangs use promises of protection or punishment inside prison to influence and organize criminal activity on the street. Typical crime-reduction policies that make incarceration likelier and sentences harsher can increase prison gangs’ power over street-level members and affiliates, a formal model shows. Leading cases from the Americas corroborate these predictions: periods of sharply rising incarceration, driven partly by anti-gang laws, preceded qualitative leaps in prison-gang power on the street. Critically, prison gangs use this capacity not only to govern and tax criminal markets but also to win leverage over state officials by orchestrating terror attacks, intentionally curtailing quotidian violence, or both. Thus, even if increased incarceration leads to reduced crime, it may do so by strengthening prison-gang power at the expense of state authority.
The benefit of simultaneously encountered exemplars and of exemplar variability to verb learning

Abstract Young children are conservative when extending novel verbs to novel exemplars. We investigated whether multiple, simultaneously presented exemplars would aid young children's verb learning, as well as the importance of exemplar variability. Three-year-olds were taught novel verbs, while viewing either one action-scene featuring a novel action performed on a novel object, or two action-scenes side-by-side in which the action performed was the same but the object varied, or two action-scenes side-by-side in which no aspect of the scenes varied. They were asked to extend the novel verbs to one of two scenes: one that maintained the action and one that maintained the object. Findings indicated that children were only able to extend verbs correctly after viewing two action-scenes in which the content varied. These findings suggest that simultaneously presented exemplars of a verb can support verb learning in younger children, but only when the content of the exemplars varies.
SPG-Net: Segmentation Prediction and Guidance Network for Image Inpainting

In this paper, we focus on image inpainting task, aiming at recovering the missing area of an incomplete image given the context information. Recent development in deep generative models enables an efficient end-to-end framework for image synthesis and inpainting tasks, but existing methods based on generative models don't exploit the segmentation information to constrain the object shapes, which usually lead to blurry results on the boundary. To tackle this problem, we propose to introduce the semantic segmentation information, which disentangles the inter-class difference and intra-class variation for image inpainting. This leads to much clearer recovered boundary between semantically different regions and better texture within semantically consistent segments. Our model factorizes the image inpainting process into segmentation prediction (SP-Net) and segmentation guidance (SG-Net) as two steps, which predict the segmentation labels in the missing area first, and then generate segmentation guided inpainting results. Experiments on multiple public datasets show that our approach outperforms existing methods in optimizing the image inpainting quality, and the interactive segmentation guidance provides possibilities for multi-modal predictions of image inpainting.
Management of patients with anterior abdominal stab wounds: a Western Trauma Association multicenter trial.

BACKGROUND The optimal management of hemodynamically stable, asymptomatic patients with anterior abdominal stab wounds (AASWs) remains controversial. The goal is to identify and treat injuries in a safe, cost-effective manner. Common evaluation strategies include local wound exploration (LWE)/diagnostic peritoneal lavage (DPL), serial clinical assessments (SCAs), and computed tomography (CT) imaging. The purpose of this multicenter study was to evaluate the clinical course of patients managed by the various strategies, to determine whether there are differences in associated nontherapeutic laparotomy (NONTHER LAP), emergency department (ED) discharge, or complication rates. METHODS A multicenter, Institutional Review Board-approved study enrolled patients with AASWs. Management was individualized according to surgeon/institutional protocols. Data on the presentation, evaluation, and clinical course were recorded prospectively. RESULTS Three hundred fifty-nine patients were studied. Eighty-one had indications for immediate LAP, of which 84% were therapeutic. ED D/C was facilitated by LWE, CT, and DPL in 23%, 21%, and 16% of patients, respectively. On the other hand, LAP based on abnormalities on LWE, CT, and DPL were NONTHER in 57%, 24%, and 31% of patients, respectively. Twelve percent of patients selected for SCA ultimately had LAP (33% were NONTHER); there was no apparent morbidity due to delay in intervention. CONCLUSIONS Shock, evisceration, and peritonitis warrant immediate LAP after AASW. Patients without these findings can be safely observed for signs or symptoms of bleeding or hollow viscus injury. To limit the number of hospital admissions, we propose a uniform strategy using LWE to ascertain the depth of penetration; the patient may be safely discharged in the absence of peritoneal violation. Peritoneal penetration, absent evidence of ongoing hemorrhage or hollow viscus injury, should not be considered an indication for LAP, but rather an indication for admission for SCAs. We suggest that a prospective multicenter trial be performed to document the safety and cost-effectiveness of such an approach.
The role of insulin-like growth factor axis in bladder cancer : a systemic review and meta analysis

Background: The role of the IGF axis in bladder cancer has been extensively studied in recent years, but the results are controversial. Methods: Pubmed, Embase, China national knowledge infrastructure and Wanfang databases were searched to identify eligible studies to evaluate the association among IGF-1, IGFBP-3, IGF-1R and IMP-3 expression and bladder cancer risk, depth of invasion and recurrence. Results: 15 studies were involved in the analysis, 5 of them reported the relation between serum concentration of IGF-1 or IGFBP-3 and bladder cancer risk. The difference in serum IGF-1 concentration was not significant between patients with bladder cancer and health controls (P=0.57). The serum IGFBP-3 concentration was lower in patients with bladder cancer (SMD: -0.78, 95% CI: -1.40, -0.15). 10 studies were involved in the analysis of the relation between IGF-1R or IMP-3 expression and bladder cancer. The expressions of IGF-1R and IMP-3 were elevated in MIBC compared with NMIBC (OR: 0.30, 95% CI: 0.19, 0.48 and OR: 0.30, 95% CI: 0.19, 0.46). The expressions of IGF-1R and IMP-3 were also found to be elevated in recurrent bladder cancer compared with primary bladder cancer (OR: 5.05, 95% CI: 2.43, 10.51 and OR: 2.47, 95% CI 1.48, 4.13). Conclusion: The IGF axis plays an important role in tumor proliferation and invasion, recurrence and metastasis. IGFBP-3 may be a potential serum biomarker for the screening of bladder cancer. The elevated expressions of IGF-1R and IMP3 in tissue are symbols of a highly malignant bladder cancer, and they could be utilized in the molecular classification of bladder. IGF-1R may be a promising therapeutic target for bladder cancer, but further studies are needed to evaluate the sensitivity of bladder cancer to the new targeted drugs and the predictive effect of serum IGFs in the targeted therapy.
Morphological changes during postnatal growth and reproduction in the brown long-eared bat Plecotus auritus: implications for wing loading and predicted flight performance

Patterns of postnatal growth, and changes in mass and wing loading during reproduction were studied in captive free-flying brown long-eared bats (Plecotus auritus, Linnaeus, 1758). The bats were fed on noctuid moths occasionally supplemented with mealworms. Growth in body mass was best described by the von Bertalanffy model (n = 5 individuals), while growth in forearm length, wingspan and wing area, were best described by the logistic equation (n = 5 individuals). Because the wings developed more rapidly than body mass, wing loading decreased from high levels following birth to a minimum at around 30 days of age. Predicted mechanical power requirements for flight (minimum power Pmp and maximum range power Pmr) and the corresponding flight speeds (Vmp and Vmr) as well as the minimum theoretical radius of a banked turn (rmin) also reached minima at this time. At 30 days of age juveniles could fly with lower predicted power requirements and were more manoeuvrable (could fly more slowly at minimum power and make tighter turns) than adults. These minima corresponded to the time when juveniles first left the roost box to fly. Reproductive females (n = 6) displayed a near two-fold increase in body mass and wing loading over 50 days prior to birth. This resulted in a three-fold increase in the predicted mechanical power requirements for flight (Pmp and Pmr), and a decrease in predicted flight manoeuvrability. Non-reproductive individuals (n = 22) had a similar pattern but increased in body mass and wing loading to a lesser extent. Over days 1 to 40 postpartum, both mass and wing loading declined in lactating females, but continued to increase in the non-reproductive bats.
Expression and distribution of metabotropic GABA receptor subtypes GABABR1 and GABABR2 during rat neocortical development

To understand the possible contribution of metabotropic γ‐aminobutyric acid receptors (GABABR) in cortical development, we investigated the expression pattern and the cellular and subcellular localization of the GABABR1 and GABABR2 subtypes in the rat neocortex from embryonic day 14 (E14) to adulthood. At the light microscopic level, both GABABR1 and GABABR2 were detected as early as E14. During prenatal development, both subtypes were expressed highly in the cortical plate. Using double immunofluorescence, GABABR1 colocalized with GABABR2 in neurons of the marginal zone and subplate, indicating that these proteins are coexpressed and could be forming functional GABABRs during prenatal development in vivo. In contrast, only GABABR1 but not GABABR2 was detected in the tangentially migratory cells in the lower intermediate zone. During postnatal development, immunoreactivity for GABABR1 and GABABR2 was distributed mainly in pyramidal cells. Discrete GABABR1‐immunopositive cell bodies of interneurons were present throughout the neocortex. In addition, GABABR1 but not GABABR2 was found in identified Cajal‐Retzius cells in layer I. At the electron microscopic level, immunoreactivity for GABABR1 and GABABR2 was found in dendritic spines and dendritic shafts at extrasynaptic and perisynaptic sites throughout postnatal development. We further demonstrated the presynaptic localization of GABABR1 and GABABR2, as well as the association of the receptors with asymmetrical synaptic junctions. These results indicate potentially important roles for the GABABRs in the regulation of migratory processes during corticogenesis and in the modulation of synaptic transmission during early development of cortical circuitry.
Occlusal traits and orthodontic treatment need in 7‐ to 10‐year‐olds in Estonia

The aim of this study was to evaluate the distribution of occlusal traits and orthodontic treatment need and complexity in Estonian 7‐ to 10‐year‐old children. This data provides solid information for planning of orthodontic care. Data of 392 Estonian children (198 girls and 194 boys, mean age 9.0 years, range 7.1–10.4 years) was analysed in this cross‐sectional study. Assessed traits included first molar and canine sagittal relationship, overjet, overbite, crowding, midline diastema, crossbite, and scissor bite. Orthodontic treatment need and complexity were assessed using the Index of Complexity, Outcome, and Need. Parents' opinion regarding their child's teeth was determined using a questionnaire. The most prevalent occlusal traits were canine class I sagittal relationship (73.7%), midline diastema (73.0%), molar class I sagittal relationship (57.4%), and overbite ≥3.5 mm (51.8%). According to the Index of Complexity, Outcome, and Need, 64.3% of Estonian elementary school children were in need of orthodontic treatment. Treatment complexity was simple in 12.5%, mild in 38.8%, moderate in 22.7%, difficult in 14.0%, and very difficult in 12.0% of the children. Approximately 66.4% of the parents felt that their child needed orthodontic treatment. This study confirms earlier findings indicating that the most frequent sagittal relationship is class I in the first molars and class I in the canines. However, the sagittal relationship was asymmetric in more than half of the children. Correlation between objectively defined treatment need and parents' desire for treatment was high in Estonia.
Fast-SG: an alignment-free algorithm for hybrid assembly

Long read sequencing technologies are the ultimate solution for genome repeats, allowing near reference level reconstructions of large genomes. However, long read de novo assembly pipelines are computationally intense and require a considerable amount of coverage, thereby hindering their broad application to the assembly of large genomes. Alternatively, hybrid assembly methods which combine short and long read sequencing technologies can reduce the time and cost required to produce de novo assemblies of large genomes. In this paper, we propose a new method, called FAST-SG, which uses a new ultra-fast alignment-free algorithm specifically designed for constructing a scaffolding graph using light-weight data structures. FAST-SG can construct the graph from either short or long reads. This allows the reuse of efficient algorithms designed for short read data and permits the definition of novel modular hybrid assembly pipelines. Using comprehensive standard datasets and benchmarks, we show how FAST-SG outperforms the state-of-the-art short read aligners when building the scaffolding graph, and can be used to extract linking information from either raw or error-corrected long reads. We also show how a hybrid assembly approach using FAST-SG with shallow long read coverage (5X) and moderate computational resources can produce long-range and accurate reconstructions of the genomes of Arabidopsis thaliana (Ler-0) and human (NA12878).
Staff-perceived Conflict between Resident-centered Care and Quality in the Skilled Nursing Facility: Are Both Possible?

ABSTRACT Objectives: The purpose of this study was to understand if and how Veterans Affairs (VA) nursing home (CLC) staff experience difficulty in providing care that is both resident-centered (RCC) and concordant with quality standards. Methods: Twelve VA CLCs were selected for site visits, stratified based on rankings on a composite quality measure (calculated from various indicators) and resident-centered care (RCC) progress (based on a culture change tool). Staff were interviewed about efforts and barriers to achieving goals in RCC and quality, and the interview transcripts systematically analyzed for themes. Results: We interviewed 141 participants, including senior leaders, middle managers, and front-line staff. An emergent theme was conflict between RCC and quality, although participants varied in their perceptions of its impact. Participants perceived three conflict types: 1) between resident preferences and medically indicated actions; 2) between resident preferences and the needs or safety of others; and 3) limits of staff time or authority. Conclusions: CLC staff perceive conflicts between RCC and care consistent with quality imperatives. Clinical implications: Variation in perceived RCC-quality conflicts suggests that policy clarifications and additional training may provide guidance in dealing with such dilemmas. It may be prudent to clearly communicate to what boundaries exist to RCC in the evolving CLC environment.
Human Macrophages Preferentially Infiltrate the Superficial Adipose Tissue

Human abdominal subcutaneous adipose tissue consists of two individual layers—the superficial adipose tissue (SAT) and deep adipose tissue (DAT)—separated by the Scarpa’s fascia. The present study focuses on the analysis of morphological and immunological differences of primary adipocytes, adipose-derived stem cells (ASC), and tissue-infiltrating immune cells found in SAT and DAT. Adipocytes and stromal vascular fraction (SVF) cells were isolated from human SAT and DAT specimens and phenotypically characterized by in vitro assays. Ex vivo analysis of infiltrating immune cells was performed by flow cytometry. Primary adipocytes from SAT are larger in size but did not significantly differ in cytokine levels of LEPTIN, ADIPOQ, RBP4, CHEMERIN, DEFB1, VISFATIN, MCP1, or MSCF. ASC isolated from SAT proliferated faster and exhibited a higher differentiation potential than those isolated from DAT. Flow cytometry analysis indicated no specific differences in the relative numbers of ASC, epithelial progenitor cells (EPC), or CD3+ T-cells, but showed higher numbers of tissue-infiltrating macrophages in SAT compared to DAT. Our findings suggest that ASC isolated from SAT have a higher regenerative potential than DAT-ASC. Moreover, spatial proximity to skin microbiota might promote macrophage infiltration in SAT.