Miracle-dz/UniFAR-FTUs huggingface dataset:
Sexual Consent

SUMMARY What role can the criminal law play in the battle against child sexual abuse? Should sexual relations of, and with, persons under a certain age be criminalized regardless of the circumstances, even if they are consensual (“age of consent”, “minimum age”)? Where should such a minimum age-limit be fixed? Should there be a special, higher age-limit for particular conditions (e.g., “seduction”, “corruption”)? Should sexual contacts with minors within a relationship of authority be criminalized generally or just if authority is abused? Should criminal proceedings be instituted ex officio or upon complaint only? Should authorities be provided with a power of discretion or should they be obliged to prosecute and sentence in each case? In answering these important questions, it is highly beneficial to have a look across the borders to the solutions other countries have reached in this area. This analysis will provide an overview on the criminal law governing the sexual behavior of, and with, children and adolescents in all European jurisdictions and in selected jurisdictions outside of Europe. It will show which categories of offenses exist and from which age onward young people can effectively consent to various kinds of sexual behavior and relations in the different countries. It turns out that all states in Europe and all of the studied jurisdictions overseas do have minimum age limits for sexual relations, do punish sexual relations with persons under a certain age. Nowhere is this age set lower than 12 years. In Europe in one-half of the jurisdictions, consensual sexual relations with 14-year-old adolescents are legal; in two-thirds with 15-year-olds; in a majority, this is also the case when the older partner has started the initiative (and also when the initiative contains an offer of remuneration). In nearly all jurisdictions, such relations are legal from the age of 16 onwards. Nearly all European jurisdictions set the same age limit in the criminal law for depicting sexual activity as for the sexual activity itself. Most states apply a higher age limit for contacts in relationships of authority. If the authority is not misused the age limit in most jurisdictions is set between 14 and 16; if it is misused between 16 and 18. Most states make no difference between heterosexual and homosexual relations.
Cytotoxic aporphine alkaloids from Cassytha filiformis.

Purification of a cytotoxic crude alkaloid extract of Cassytha filiformis led to the isolation of four known aporphine alkaloids: neolitsine, dicentrine, cassythine (= cassyfiline) and actinodaphnine. Their structures were determined by analysis of spectroscopic data. All isolated alkaloids were tested for their cytotoxic activities on cancer and non-cancer cell lines in vitro. Neolitsine was the most active against HeLa and 3T3 cells (IC 50 :21.6 microM, and 21.4 microM, respectively). Cassythine and actinodaphnine showed the highest activity against Mel-5 (IC 50 : 24.3 microM and 25.7 microM, respectively) and HL-60 (IC 50 : 19.9 microM and 15.4 microM, respectively). This is the first report on the cytotoxic activity of C. filiformis extract and of neolitsine and cassythine. Furthermore, the complete NMR data of cassythine and actinodaphnine are given here for the first time.
The membrane repair response masks membrane disturbances caused by cell‐penetrating peptide uptake

Although cell‐penetrating peptides are able to deliver cargo into cells, their uptake mechanism is still not fully understood and needs to be elucidated to improve their delivery efficiency. Herein, we present evidence of a new mechanism involved in uptake, the membrane repair response. Recent studies have sug‐gested that there might be a direct penetration of peptides in parallel with different forms of endocyto‐sis. The direct penetration of hydrophilic peptides through the hydrophobic plasma membrane, however, is highly controversial. Three proteins involved in tar‐get cell apoptosis—perforin, granulysin, and gran‐zymes—share many features common in uptake of cell‐penetrating peptides (e.g., they bind proteoglycans). During perforin uptake, the protein activates the membrane repair response, a resealing mechanism triggered in cells with injured plasma membrane, because of extracellular calcium influx. On activation of the membrane repair response, internal vesicles are mobilized to the site of the disrupted plasma mem‐brane, resealing it within seconds. In this study, we have used flow cytometry, fluorescence, and electron microscopy, together with high‐performance liquid chroma‐tography and mass spectrometry, to present evidence that the membrane repair response is able to mask damages caused during cell‐penetrating peptide up‐take, thus preventing leakage of endogenous molecules out of the cell. —Palm‐Apergi, C. , Lorents, A. , Padari, K. , Pooga, M. , and Hallbrink, M. The membrane repair response masks membrane disturbances caused by cell‐penetrating peptide uptake. FASEB J. 23, 214‐223 (2009)
The effects of self-regulated learning training on community college students’ metacognition and achievement in developmental math courses

ABSTRACT The effects of training in self-regulation on metacognition and math achievement were investigated. The participants were 116 community college students enrolled in developmental math courses. Students enrolled in 16 classrooms were randomly assigned to the treatment and control groups. Participants in the treatment group completed four self-regulated learning (SRL) exercises based on Zimmerman’s (2002) cyclical model. The exercises were completed weekly and repeated for a total of 3 weeks. During the last week of class, participants completed a final exam to measure math achievement as well as the metacognitive self-regulation and time/study environment management scales on the Motivated Strategies for Learning Questionnaire ([MSLQ], Pintrich, Smith, Garcia, & McKeachie, 1991). There were significant differences between the two groups, indicating that training in SRL improved math achievement and metacognitive skills assessed on both MSLQ scales. The findings suggested that training in SRL improves math achievement, metacognitive self-regulation and time/study environmental management skills of students enrolled in developmental math courses.
Probing of Brain States in Real-Time: Introducing the ConSole Environment

Recent years have seen huge advancements in the methods available and used in neuroscience employing EEG or MEG. However, the standard approach is to average a large number of trials for experimentally defined conditions in order to reduce intertrial-variability, i.e., treating it as a source of “noise. ” Yet it is now more and more accepted that trial-to-trial fluctuations bear functional significance, reflecting fluctuations of “brain states” that predispose perception and action. Such effects are often revealed in a pre-stimulus period, when comparing response variability to an invariant stimulus. However such offline analyses are disadvantageous as they are correlational by drawing conclusions in a post hoc-manner and stimulus presentation is random with respect to the feature of interest. A more direct test is to trigger stimulus presentation when the relevant feature is present. The current paper introduces Constance System for Online EEG (ConSole), a software package capable of analyzing ongoing EEG/MEG in real-time and presenting auditory and visual stimuli via internal routines. Stimulation via external devices (e.g., transcranial magnetic stimulation) or third-party software (e.g., PsyScope X) is possible by sending TTL-triggers. With ConSole it is thus possible to target the stimulation at specific brain states. In contrast to many available applications, ConSole is open-source. Its modular design enhances the power of the software as it can be easily adapted to new challenges and writing new experiments is an easy task. ConSole is already pre-equipped with modules performing standard signal processing steps. The software is also independent from the EEG/MEG system, as long as a driver can be written (currently two EEG systems are supported). Besides a general introduction, we present benchmark data regarding performance and validity of the calculations used, as well as three example applications of ConSole in different settings. ConSole can be downloaded at: http://console-kn.sf. net.
On (partial) unit memory codes based on Reed-Solomon codes for streaming

For streaming codes an erasure channel is assumed and the decoding delay is one of the main parameters to be considered. In this paper the erasure correcting capability of unit memory convolutional codes based on disjoint RS codes is analyzed. We take a sliding window decoder approach, where only the most current information is decoded before sliding the window one time-step further. We show that when we restrict the decoding delay to a small value, these codes still achieve an excellent erasure correction performance. This makes these codes useful for streaming applications where low latency is required.
Image-based point spread function implementation in a fully 3D OSEM reconstruction algorithm for PET

The interest in positron emission tomography (PET) and particularly in hybrid integrated PET/CT systems has significantly increased in the last few years due to the improved quality of the obtained images. Nevertheless, one of the most important limits of the PET imaging technique is still its poor spatial resolution due to several physical factors originating both at the emission (e.g. positron range, photon non-collinearity) and at detection levels (e.g. scatter inside the scintillating crystals, finite dimensions of the crystals and depth of interaction). To improve the spatial resolution of the images, a possible way consists of measuring the point spread function (PSF) of the system and then accounting for it inside the reconstruction algorithm. In this work, the system response of the GE Discovery STE operating in 3D mode has been characterized by acquiring 22Na point sources in different positions of the scanner field of view. An image-based model of the PSF was then obtained by fitting asymmetric two-dimensional Gaussians on the 22Na images reconstructed with small pixel sizes. The PSF was then incorporated, at the image level, in a three-dimensional ordered subset maximum likelihood expectation maximization (OS-MLEM) reconstruction algorithm. A qualitative and quantitative validation of the algorithm accounting for the PSF has been performed on phantom and clinical data, showing improved spatial resolution, higher contrast and lower noise compared with the corresponding images obtained using the standard OS-MLEM algorithm.
Fc Gamma Receptor CD64 Modulates the Inhibitory Activity of Infliximab

Background Tumor necrosis factor (TNF) is an important cytokine in the pathogenesis of inflammatory bowel disease (IBD). Anti-TNF antibodies have been successfully implemented in IBD therapy, however their efficacies differ among IBD patients. Here we investigate the influence of CD64 Fc receptor on the inhibitory activity of anti-TNFs in cells of intestinal wall. Methods Intestinal cell lines, monocytes/macrophages and peripheral blood mononuclear cells (PBMCs) were used as models. The efficacies of adalimumab, infliximab and certolizumab-pegol were assessed by RT-PCR for target genes. Protein levels and localizations were examined by Western blotting and immunofluorescence. Antibody fragments were obtained by proteolytic digestion, immunoprecipitation and protein chip analysis. Knock-down of specific gene expression was performed using siRNAs. Results Infliximab had limited efficacy towards soluble TNF in cell types expressing Fc gamma receptor CD64. Both adalimumab and infliximab had lower efficacies in PBMCs of IBD patients, which express elevated levels of CD64. Infliximab-TNF complexes were more potent in activating CD64 in THP-1 cells than adalimumab, which was accompanied by distinct phospho-tyrosine signals. Blocking Fc parts and isolation of Fab fragments of infliximab improved its efficacy. IFN-γ-induced expression of CD64 correlated with a loss of efficacy of infliximab, whereas reduction of CD64 expression by either siRNA or PMA treatment improved inhibitory activity of this drug. Colonic mRNA expression levels of CD64 and other Fc gamma receptors were significantly increased in the inflamed tissues of infliximab non-responders. Conclusions CD64 modulates the efficacy of infliximab both in vitro and ex vivo, whereas the presence of this receptor has no impact on the inhibitory activity of certolizumab-pegol, which lacks Fc fragment. These data could be helpful in both predicting and evaluating the outcome of anti-TNF therapy in IBD patients with elevated systemic and local levels of Fc receptors.
THE POINT OF NO RETURN: ABORIGINAL OFFENDERS' JOURNEY TOWARDS A CRIME FREE LIFE

The goal of this study was to gather information from Aboriginal offenders and develop a categorical map that describes the factors that help and hinder maintaining a crime free life after incarceration. The critical incident technique was utilized to examine 42 Aboriginal offenders’ journeys from prison to the community. Three hundred and forty-one incidents collapsed into nine major categories representing themes that were helpful in maintaining a crime free life: 1) transformation of self; 2) cultural and traditional experiences; 3) healthy relationships; 4) having routine and structure in daily living; 5) freedom from prison; 6) purpose and fulfillment in life; 7) attempting to live alcohol and drug free; 8) professional support and programming; and 9) learning to identify and express oneself. Seventy-eight incidents formed four categories representing obstacles that interfere with maintaining a crime free life: 1) self; 2) unhealthy relationships; 3) substance use; and 4) lack of opportunity and professional support. The findings were compared and contrasted to two major theories in the literature: desistance and the risk-needs-responsivity principle. Most of the categories were well substantiated in the literature contributing knowledge to theory, policy, practice, and the community. Information obtained from this study provides an increased understanding of the needs of Aboriginal offenders and offers guidance concerning useful strategies to incorporate into their wellness plans when entering the community, most notably respecting Aboriginal culture and traditional practices. The findings also add awareness of those circumstances, issues, and problems that arise during transition that may be harmful or create obstacles to a successful transition.
Cortical area V4 is critical for certain texture discriminations, but this effect is not dependent on attention

This study examined the question of which features of a complex grouping discrimination make it vulnerable to permanent elimination by V4 lesions. We first verified that the line element grouping discrimination, which we previously reported to be devastated by V4 lesions, was similarly affected in the monkeys of this study. The permanence of the deficit was established by mapping its visual field distribution and then testing this discrimination for an extended period at a locus on the border of the deficit. Also, a staircase procedure was used to provide the monkey with within session instruction in the grouping discrimination, but this did not improve V4 lesion performance. Grouping was then compared with several discriminations that shared some features with it, but which were found not to be permanently eliminated by V4 lesions. This comparison suggested that grouping (rather than segmentation or response to a single element) was one feature that made the discrimination vulnerable, a second was the similarity in shape of the texture elements to be grouped. Finally, we tested visual crowding, a property of peripheral vision that is thought to reflect neuronal interactions early in visual cortex, possibly in area V1, and found no effect of V4 lesions. A control experiment with human observers tested whether the elimination of grouping by V4 lesions might be due to an alteration of attention, but found no evidence to support this hypothesis. These results show that severe disruption of texture discriminations by V4 lesions depends on both the nature of the discrimination and the type of texture elements involved, but does not necessarily involve the disruption of attention.
Finding Intermediary Topics Between People of Opposing Views: A Case Study

In micro-blogging platforms, people can connect with others and have conversations on a wide variety of topics. However, because of homophily and selective exposure, users tend to connect with like-minded people and only read agreeable information. Motivated by this scenario, in this paper we study the diversity of intermediary topics, which are latent topics estimated from user generated content. These topics can be used as features in recommender systems aimed at introducing people of diverse political viewpoints. We conducted a case study on Twitter, considering the debate about a sensitive issue in Chile, where we quantified homophilic behavior in terms of political discussion and then we evaluated the diversity of intermediary topics in terms of political stances of users.
On the formation of cold fronts in massive mergers

Using adiabatic hydrodynamical simulations, we follow the evolution of two symmetric cold fronts forming in the remnant of a violent z= 0.3 massive cluster merger. Because the fronts develop after the first passage of the two gas cores of the merging subclusters, and because they soon move ahead of their associated dark matter cores, both the structure and the location of our simulated cold fronts may correspond to a stage that is later than that of most cold fronts observed so far. The cold fronts are preceded by a roughly spherical shock that originates in the centre of the cluster and disappears in the outer regions after 1.6 Gyr. The cold fronts last longer, until z∼ 0. We follow the spatial evolution of the gas of the subcluster cores, and find that a fraction of this gas is liberated in the intracluster medium after core passage, but mainly at apocentre, and that it does not fall back onto the cluster centre. Conversely, we trace back the low-temperature gas constituting the fronts and find that it is initially associated with the two dense cores of the merging clusters. In addition, we find some evidence for discontinuity of the gas velocity field across the edge of the forming cold fronts, suggesting the presence of a contact discontinuity there. In the light of other recent work, we then speculate on the physical mechanism resulting in the cold fronts. We suggest that sloshing induced by strongly varying ram pressure along the subcluster's orbit and/or spatial segregation between the dark matter and gas components of the cores of the subclusters results in strong tidal forces on the gas, and that these forces could be responsible for the deposition of part of the cold dense gas in the surrounding hot intracluster medium. This deposited gas then expands, cools down further, and constitutes the cold fronts.
Performance Analysis of Approximate Message Passing for Distributed Compressed Sensing

Bayesian approximate message passing (BAMP) is an efficient method in compressed sensing that is nearly optimal in the minimum mean squared error (MMSE) sense. Multiple measurement vector (MMV)-BAMP performs joint recovery of multiple vectors with identical support and accounts for correlations in the signal of interest and in the noise. In this paper, we show how to reduce the complexity of vector BAMP via a simple joint decorrelation (diagonalization) transform of the signal and noise vectors, which also facilitates the subsequent performance analysis. We prove that the corresponding state evolution is equivariant with respect to the joint decorrelation transform and preserves diagonality of the residual noise covariance for the Bernoulli–Gauss prior. We use these results to analyze the dynamics and the mean squared error (MSE) performance of BAMP via the replica method, and thereby understand the impact of signal correlation and number of jointly sparse signals. Finally, we evaluate an application of MMV-BAMP for single-pixel imaging with correlated color channels and thereby explore the performance gain of joint recovery compared to conventional BAMP reconstruction as well as group lasso.
Can Sea Lions' (Zalophus californianus) Use Mirrors to Locate an Object?

Author(s): Hill, Heather M. ; Webber, Krista; Kemery, Alicia; Garcia, Melissa; Kuczaj, II, Stan A | Abstract: Although California sea lions (Zalophus californianus) are capable of forming complex mental concepts, they have failed to demonstrate mirror self-recognition, a skill that requires both a mental representation of one’s physical features and knowledge of a reflective surface. Many non-human species that do not recognize themselves in mirrors can nonetheless learn to use mirror reflections to locate and retrieve objects. A total of 7 sea lions housed at 2 separate facilities were tested on their ability to detect an object using a mirror. The results of a preliminary detection task in which sea lions were reinforced for looking at a mirror to locate an object suggested that 4 sea lions reliably learned to locate an object positioned below a mirror in one of three locations. A follow-up study was conducted to determine if 3 different sea lions could learn the task without training the animals to use the mirrors. Two of the 3 sea lions located a single object in 1 of the 3 locations statistically above chance when the mirrors were added to the task for the first time. With additional mirror exposure, 1 sea lion successfully achieved 100% accuracy in detecting familiar objects placed in 1 of 3 familiar locations. This sea lion also demonstrated her ability to detect an object via a mirror located in a novel, fourth position with 100% accuracy. When two novel objects were tested with four locations, the sea lion again performed well, detecting the objects 87.5%. The results suggest that sea lions have the ability to use mirrors to locate an object with minimal exposure to a mirror, but likely need additional experience with mirrors to efficiently use the properties of these reflective surfaces and understand that the image is a two-dimensional representation of a three-dimensional object.
Scripting professional identities: how individuals make sense of contradictory institutional logics

This article examines how individual accountants subjectively interpret competing logics of professionalism as they transform from practicing accountants to managerial roles and as their organizations transform from traditional professional partnerships to more corporate organizational forms. Based on a longitudinal ethnography of professionals in a Big Four accounting firm we analyse the process by which individual professionals make sense of their new roles and integrate the conflicting demands of professional and managerial logics. We find that individuals are active authors of their own identity scripts. We further observe considerable interpretive variation in how identity scripts are reproduced and enacted. We contribute to the emerging understanding of institutions as ‘inhabited’ by individuals and extend this literature by demonstrating that the institutional work of reinterpreting competing logics is based less of inter-subjective interactions, as prior literature has assumed, and is, instead, based on individual cognition and interpretive subjectivity. We also contribute to research in professional service firms by offering a conceptual model of the individual micro-processes required for successful archetypal change.