Miracle-dz/UniFAR-FTUs huggingface dataset:
Eros in the Field? Bourdieu's Double Account of Socialized Desire

In his later works, Bourdieu draws extensively on psychoanalytic approaches in accounting for his concept of socialized subjectivity as bound to the social world by an intense affective grip. This emotional turn holds potential for further developing Bourdieu's account of subjectivity as a formation of socialized desire. However, in accounting for this socialized desire, Bourdieu relapses into a dualism of subjective and objective structures, incompatible with the Merleau-Pontyian roots of his practice theory. Tracing this problem to the antagonism between desire and culture in the psychoanalytic accounts that Bourdieu draws on, I propose that the psychoanalytic scholar Hans Loewald's account of Eros may enable a move beyond this impasse, offering a promising conceptual basis for taking further the account of socialized subjectivity and socialized desire in Bourdieu's practice theory.
Relative types and extremal problems for plurisubharmonic functions

We study properties of relative types of plurisubharmonic functions with respect to maximal plurisubharmonic weights. It is shown that they give a general form for upper semicontinuous, tropically additive functionals on plurisubharmonic singularities. We consider some extremal problems whose solutions are Green-like functions that give best possible bounds on a plurisubharmonic function, given the values of its types relative to some of (or all) the weights. An analyticity theorem is proved for the upperlevel sets for the types with respect to exponentially H\"older continuous weights, which leads to a result on propagation of plurisubharmonic singularities.
[Effect of arecoline on the differentiation of myofibroblasts of oral mucosa].

OBJECTIVE To investigate the origin of myofibroblasts in oral submucous fibrosis. METHODS The oral keratinocytes and fibroblasts were isolated and cultured. The expression of the alpha-smooth muscle actin in the fibroblasts was examined by immunohistochemistry and reverse transcriptase polymerase chain reaction (RT-PCR). RESULTS No difference was found in expression of alpha-smooth muscle actin between the fibroblasts that were directly stimulated by arecoline and the control. The expression of alpha-smooth muscle actin in the keratinocyte and fibroblast-cocultured group was higher than in the control group, and higher in fibroblasts cocultured with keratinocytes preprocessed by arecoline than in fibroblasts cocultured with keratinocytes without preprocessed by arecoline. CONCLUSIONS The differentiation of myofibroblasts from fibroblasts in oral submucous fibrosis might be induced by the interaction of arecoline and keratinocyte.
How to Measure Memorability and Social Interestingness of Images: A Review

An entire industry has been developed around keyword optimization for buyers of advertising space. However, the social media landscape has shifted to photo-driven behaviors, and there is a need to overcome the challenge of analyzing the large amount of visual data that users post on the internet. We will address this analysis by providing a review on how to measure image and video interestingness and memorability from content that is tacked in real time on social networks. We will investigate state-of-the-art methods that are used to analyze social media images and present experiments that were performed to obtain comparable results based on the studied proposals and to determine which are the best characteristics and classifiers. Finally, we will discuss future research directions that could be beneficial to both users and companies.
The Trap of Triage

In 1975, consultants from Team Four Inc. advised St. Louis planners to pursue a strategy of neighborhood triage: “conservation” for areas in good health, “redevelopment” for areas just starting to decline, and “depletion” for areas already in severe distress. The firm’s recommended strategy reflected the latest thinking among urban planners, but it provoked outrage among residents of the city’s predominantly black North Side, who read “depletion” as a promise of benign neglect. In this article, I explain how Team Four justified its advice, and why, four decades later, the controversy over its memo persists.
Fast radioactive hotspot localization using a UAV

We address the problem of hotspot seeking in an unknown radiation field using an Unmanned Aerial Vehicle (UAV) with limited resources. For on-the-spot investigation of accidental radiation releases, without a priori knowledge on the whereabouts of the source of radiation substances leakages, it is very difficult to navigate and return a UAV for fast hotspot localization. We propose a novel Hexagonal Tree (HexTree) based sampling algorithm to find such an optimal tour path based on the appropriate measurement locations. We make a realistic assumption on the environment, theoretically analyze the optimality of proposed algorithm, and numerically compare the performance with the existing method. The proposed algorithm gives faster convergence to the hotspot, an optimal exploration termination condition, and more informative locations while returning to the initial position than conventional random sampling based exploration and path smoothing algorithms.
Y25130 hydrochloride, a selective 5HT3 receptor antagonist has potent antimitogenic and apoptotic effect on HT29 colorectal cancer cell line

Serotonin (5-hydroxytryptamine, 5-HT) is known to be a mitogenic factor in several malignancies. It elicits its mitogenic effect through a wide range of 5-HT receptor subtypes and several internal cellular transcription pathways. According to wide distribution of 5-HT3 and 5-HT4 receptors in the gastrointestinal tract, the main aim of this study was to investigate the effect of these receptor agonists and antagonists in a colorectal cell line. In cell culture, we investigated the effects of 5-HT, 5-HT3 and 5-HT4 receptor agonists and antagonists on proliferation of HT29 cells. We also tested apoptosis for the receptor antagonists with TUNEL apoptosis test. In addition, we assayed effects of 5-HT receptor antagonists on cell cycle kinetics with flow cytometery. Proliferation assay revealed that phenylbiguanide (a 5-HT3 receptor selective agonist) increased proliferation of HT29 cells significantly and Y25130 hydrochloride (a 5-HT3 receptor antagonist) had the opposite effect; but for 5-HT4 receptor antagonist, these effects were not significant. In addition, potent apoptotic and cell cycle arresting effect was found for a selective 5-HT3 receptor antagonist but we have not seen any significant effect for the 5-HT4 receptor antagonist. The findings of this study provide strong evidence for the potential role of 5-HT3 receptors in colorectal cancer.
A Selected Review of the Mortality Rates of Neonatal Intensive Care Units

Introduction Newborn babies in need of critical medical attention are normally admitted to the neonatal intensive care unit (NICU). These infants tend to be preterm, have low birth weight, and/or have serious medical conditions. Neonatal survival varies, but progress in perinatal and neonatal care has notably diminished mortality rates. In this selected review, we examine and compare the NICU mortality rates and etiologies of death in different countries. Methods A literature search was conducted in Ovid MEDLINE, OLDMEDLINE, EMBASE Classic, and EMBASE. The primary endpoint was the mortality rates in NICUs. Secondary endpoints included the reasons for death and the correlation between infant age and mortality outcome. For the main analysis, we examined all infants admitted to NICUs. Subgroup analyses included extremely low birth weight infants (based on the authors’ own definition), very low birth weight infants, very preterm infants, preterm infants, preterm infants with a birth weight of ≤1,500 g, and by developed and developing countries. Results The literature search yielded 1,865 articles, of which 20 were included. The total mortality rates greatly varied among countries. Infants in developed and developing countries had similar ages at death, ranging from 4 to 20 days and 1 to 28.9 days, respectively. The mortality rates ranged from 4 to 46% in developed countries and 0.2 to 64.4% in developing countries. Conclusion The mortality rates of NICUs vary between nations but remain high in both developing and developed countries.
Approximating Connected Facility Location with Lower and Upper Bounds via LP Rounding

We consider a lower- and upper-bounded generalization of the classical facility location problem, where each facility has a capacity (upper bound) that limits the number of clients it can serve and a lower bound on the number of clients it must serve if it is opened. We develop an LP rounding framework that exploits a Voronoi diagram-based clustering approach to derive the first bicriteria constant approximation algorithm for this problem with non-uniform lower bounds and uniform upper bounds. This naturally leads to the the first LP-based approximation algorithm for the lower bounded facility location problem (with non-uniform lower bounds). We also demonstrate the versatility of our framework by extending this and presenting the first constant approximation algorithm for some connected variant of the problems in which the facilities are required to be connected as well.
Cultural Identity and Conceptualization of Depression among Native Hawaiian Women

This study seeks to understand how Native Hawaiian (NH) women identified themselves culturally and conceptualized the causes of depression, and whether there was an association between these two constructs. Among the thirty NH women who were interviewed, a quarter had a high degree of depression symptoms, and a majority expressed a strong/shared identification/affinity with their culture. Our findings suggest that social stressors that contribute to the depressive symptoms of NH women could be, in part, linked to acculturation-related factors associated with U.S. occupation of Hawai'i and their social status as native people. Future research should examine this relationship further.
PSYCHOLOGICAL DETERMINANTS OF LEISURE TIME PHYSICAL ACTIVITY PARTICIPATION AMONG PUBLIC UNIVERSITY STUDENTS IN MALAYSIA

The purpose of this study is to identify the influences of attitude, self-efficacy, and motivation on leisure time physical activity participation among undergraduate students at local public universities. The theory of planned behaviour and self-efficacy theory were used as a theoretical framework. The study sample comprised 1352 undergraduate students selected by random cluster sampling. Questionnaires were utilised to collect data. The results of the study showed that motivation and self-efficacy factors were the best predictors of leisure time physical activity participation. Furthermore, the results of path analysis revealed that the combination of attitude and self-efficacy had direct and indirect effects on motivation for leisure time physical activities participation among the students at local public universities. This study suggests that to encourage students‟ leisure time physical activity participation and involvement, the university management should plan and organise programmes to develop positive attitudes among students and increase their self-efficacy and motivation levels for physical activity participation. Key words: attitude, self-efficacy, motivation, leisure time physical activity, university students
Consequences of Lysine 72 Mutation on the Phosphorylation and Activation State of cAMP-dependent Kinase*

General strategies to obtain inactive kinases have utilized mutation of key conserved residues in the kinase core, and the equivalent Lys72 in cAMP-dependent kinase has often been used to generate a “dead” kinase. Here, we have analyzed the consequences of this mutation on kinase structure and function. Mutation of Lys72 to histidine (K72H) generated an inactive enzyme, which was unphosphorylated. Treatment with an exogenous kinase (PDK-1) resulted in a mutant that was phosphorylated only at Thr197 and remained inactive but nevertheless capable of binding ATP. Ser338 in K72H cannot be autophosphorylated, nor can it be phosphorylated in an intermolecular process by active wild type C-subunit. The Lys72 mutant, once phosphorylated on Thr197, can bind with high affinity to the RIα subunits. Thus a dead kinase can still act as a scaffold for binding substrates and inhibitors; it is only phosphoryl transfer that is defective. Using a potent inhibitor of C-subunit activity, H-89, Escherichia coli-expressed C-subunit was also obtained in its unphosphorylated state. This protein is able to mature into its active form in the presence of PDK-1 and is able to undergo secondary autophosphorylation on Ser338. Unlike the H-89-treated wild type protein, the mutant protein (K72H) cannot undergo the subsequent cis autophosphorylation following phosphorylation at Thr197. Using these two substrates and mammalian-expressed PDK-1, we can elucidate a possible two-step process for the activation of the C-subunit: initial phosphorylation on the activation loop at Thr197 by PDK-1, or a PDK-1-like enzyme, followed by second cis autophosphorylation step at Ser338.
HIGH SCHOOL STUDENTS’ AND TRAINEE SCIENCE TEACHERS’ PERCEPTIONS OF OZONE LAYER DEPLETION

The focus of this study was to identify and describe misconceptions held by pre-service science teachers and high school students regarding the ozone layer depletion. The views of the participants were investigated using a closed-form questionnaire. The analysis of the survey data indicates that many high school students and pre-service science teachers possess an array of erroneous ideas about the ozone layer damage, its causes and consequences. For a better teaching of environmental issues, this study provides some implications for both teachers and researchers of science education.
Cognitive-Behavioral Therapy for an Arab College Student With Social Phobia and Depression

Coexistent social anxiety disorder (SAD) and major depression can be highly debilitating and cause significant interference with social, occupational, and educational functioning. Cognitive-behavioral therapy (CBT) has been shown to be an effective treatment for SAD and allows for flexibility in treating individuals of diverse cultural backgrounds. At present, treatment outcome research on the efficacy of CBT among Arab individuals with anxiety and mood disorders is highly limited. The current case study presents the implementation of a manualized CBT protocol for an Arab male with SAD and a secondary diagnosis of major depression. With attention to unique cultural influences on the development and maintenance of his symptom presentation, treatment consisted of 14 individual sessions, with outcome data yielding significant reductions in social anxiety, somatic anxiety, and depression at the posttreatment assessment. This case study demonstrates the potential efficacy of manualized CBT for SAD among Arab individuals and highlights the need for further systematic investigation using randomized controlled trials.
Direct visualization of interaction between calmodulin and connexin45.

Calmodulin (CaM) is an intracellular Ca2+ transducer involved in numerous activities in a broad Ca2+ signaling network. Previous studies have suggested that the Ca2+/CaM complex may participate in gap junction regulation via interaction with putative CaM-binding motifs in connexins; however, evidence of direct interactions between CaM and connexins has remained elusive to date due to challenges related to the study of membrane proteins. Here, we report the first direct interaction of CaM with Cx45 (connexin45) of γ-family in living cells under physiological conditions by monitoring bioluminescence resonance energy transfer. The interaction between CaM and Cx45 in cells is strongly dependent on intracellular Ca2+ concentration and can be blocked by the CaM inhibitor, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride (W7). We further reveal a CaM-binding site at the cytosolic loop (residues 164-186) of Cx45 using a peptide model. The strong binding (Kd ∼ 5 nM) observed between CaM and Cx45 peptide, monitored by fluorescence-labeled CaM, is found to be Ca2+-dependent. Furthermore, high-resolution nuclear magnetic resonance spectroscopy reveals that CaM and Cx45 peptide binding leads to global chemical shift changes of 15N-labeled CaM, but does not alter the size of the structure. Observations involving both N- and C-domains of CaM to interact with the Cx45 peptide differ from the embraced interaction with Cx50 from another connexin family. Such interaction further increases Ca2+ sensitivity of CaM, especially at the N-terminal domain. Results of the present study suggest that both helicity and the interaction mode of the cytosolic loop are likely to contribute to CaM's modulation of connexins.
Corporate governance and profitability in family SMEs

We analyze the determinants of performance in small unlisted family firms and find, in line with previous studies, a positive effect associated with a family CEO. We contribute by bringing in an additional variable, the proportion of family members employed by the firm and find it to be negatively related to firm performance. There is a significant tendency for family CEOs to employ family members, which – given the negative effect of these – should offset some of the positive performance effects of a family CEO. We also analyze the effect of board size in these already small family boards, where the maximum number of board members is six. We find that even here, board size is significantly negatively associated with firm performance.
Neuropeptide Y-based recombinant peptides ameliorate bone loss in mice by regulating hematopoietic stem/progenitor cell mobilization

Ovariectomy-induced bone loss is related to an increased deposition of osteoclasts on bone surfaces. We reported that the 36-amino-acid-long neuropeptide Y (NPY) could mobilize hematopoietic stem/progenitor cells (HSPCs) from the bone marrow to the peripheral blood by regulating HSPC maintenance factors and that mobilization of HSPCs ameliorated low bone density in an ovariectomy-induced osteoporosis mouse model by reducing the number of osteoclasts. Here, we demonstrated that new NPY peptides, recombined from the cleavage of the full-length NPY, showed better functionality for HSPC mobilization than the full-length peptide. These recombinant peptides mediated HSPC mobilization with greater efficiency by decreasing HSPC maintenance factors. Furthermore, treatment with these peptides reduced the number of osteoclasts and relieved ovariectomy-induced bone loss in mice more effectively than treatment with full-length NPY. Therefore, these results suggest that peptides recombined from full-length NPY can be used to treat osteoporosis.
Utility of 11C-methionine and 11C-donepezil for imaging of Staphylococcus aureus induced osteomyelitis in a juvenile porcine model: comparison to autologous 111In-labelled leukocytes, 99m Tc-DPD, and 18F-FDG.

The aim of this study was to compare 11C-methionine and 11C-donepezil positron emission tomography (PET) with 111In-labeled leukocyte and 99m Tc-DPD (Tc-99m 3,3-diphosphono-1,2-propanedicarboxylic acid) single-photon emission computed tomography (SPECT), and 18F-fluorodeoxyglucose (18F-FDG) PET to improve detection of osteomyelitis. The tracers' diagnostic utility where tested in a juvenile porcine hematogenously induced osteomyelitis model comparable to osteomyelitis in children. Five 8-9 weeks old female domestic pigs were scanned seven days after intra-arterial inoculation in the right femoral artery with a porcine strain of Staphylococcus aureus. The sequential scan protocol included Computed Tomography, 11C-methionine and 11C-donepezil PET, 99m Tc-DPD and 111In-labelled leukocytes scintigraphy, and 18F-FDG PET. This was followed by necropsy of the pigs and gross pathology, histopathology, and microbial examination. The pigs developed a total of 24 osteomyelitic lesions, 4 lesions characterized as contiguous abscesses and pulmonary abscesses (in two pigs). By comparing the 24 osteomyelitic lesions, 18F-FDG accumulated in 100%, 111In-leukocytes in 79%, 11C-methionine in 79%, 11C-donepezil in 58%, and 99m Tc-DPD in none. Overall, 18F-FDG PET was superior to 111In-leukocyte SPECT and 11C-methionine in marking infectious lesions.
Aspects of intracellular transit of serum and lipid phases of milk.

Abstract Intracellular sites of origin of constituents of milk and mechanisms by which milk constituents are compartmentalized and transported to the apical cell surface for release into alveolar lumina have been studied by microscopists, physiologists, and cell biochemists over the past 25 or more yr. Through the efforts of these many investigators much has been learned about formation, transport, and secretion of milk constituents. However, the pace at which knowledge about milk formation has accumulated has been modest, and we have much to learn about the processes leading to formation and cellular release of milk. In view of the signal importance of lactation to mammalian life, it is regretable that so much remains to be learned about the differentiated mammary epithelial cell.
The empirics of the median voter: democracy, redistribution and the role of the middle class

The paper investigates the effectiveness of the median voter as a decisive agent in the process of redistribution. According to the previous literature, it tests several assumptions finding interesting results: The positive relation between inequality and redistribution is confirmed, but the median voter theorem seems not to be the driving force of this mechanism. Even if some results support the median voter hypotheses, many others go in the opposite direction. Moreover, results are in support of the presence of a political bias toward rich classes, particularly in non established democracies. Finally, the elasticity of redistribution to poor classes to their income has decreased over the last decade, suggesting a reduction of the policies in support of low income individuals.
EFFECTS OF RECREATIONAL DISTURBANCE ON BREEDING BLACK OYSTERCATCHERS : SPECIES RESILIENCE AND CONSERVATION IMPLICATIONS

The potential conflict between increasing recreational activities and nesting birds in coastal habitats has raised concerns about the conservation of the black oystercatcher (Haematopus bachmani). To address these concerns, I studied the breeding ecology of black oystercatchers in Kenai Fjords National Park and examined the impact of recreational disturbance on breeding parameters. Most recreational disturbance of breeding territories was from kayak campers and occurred after June 13, the peak hatch of first clutches. Mean annual fledging success (24%) was low, but the results suggest that daily survival rates of nests and broods did not differ between territories with and without recreational disturbance. Nest survival varied annually and seasonally, and declined during periods of extreme high tides. Daily survival rate of broods was higher on island territories than mainland territories, presumably due to differences in predator communities. Most (95%) color-banded oystercatchers returned to their breeding territories in the subsequent year regardless of level of disturbance. On average, black oystercatchers decreased incubation constancy by 39% in response to experimental disturbance. However, I found no evidence that time off the nest was associated with probability of nest survival. Further, I found no evidence that oystercatchers habituated to recreational activity. The data suggest that black oystercatchers in Kenai Fjords National Park are resilient to the current low levels of recreational disturbance.