Miracle-dz/UniFAR-FTUs huggingface dataset:
On the interplay of network structure and gradient convergence in deep learning

The regularization and output consistency behavior of dropout and layer-wise pretraining for learning deep networks have been fairly well studied. However, our understanding of how the asymptotic convergence of backpropagation in deep architectures is related to the structural properties of the network and other design choices (like denoising and dropout rate) is less clear at this time. An interesting question one may ask is whether the network architecture and input data statistics may guide the choices of learning parameters and vice versa. In this work, we explore the association between such structural, distributional and learnability aspects vis-à-vis their interaction with parameter convergence rates. We present a framework to address these questions based on convergence of backpropagation for general nonconvex objectives using first-order information. This analysis suggests an interesting relationship between feature denoising and dropout. Building upon these results, we obtain a setup that provides systematic guidance regarding the choice of learning parameters and network sizes that achieve a certain level of convergence (in the optimization sense) often mediated by statistical attributes of the inputs. Our results are supported by a set of experimental evaluations as well as independent empirical observations reported by other groups.
Diffusion and Persistence of Multidrug Resistant Salmonella Typhimurium Strains Phage Type DT120 in Southern Italy

Sixty-two multidrug resistant Salmonella enterica serovar Typhimurium strains isolated from 255 clinical strains collected in Southern Italy in 2006–2008 were characterised for antimicrobial resistance genes, pulsotype, and phage type. Most strains (83.9%) were resistant to ampicillin, chloramphenicol, streptomycin, sulfamethoxazole, and tetracycline (ACSSuT) encoded in 88.5% by the Salmonella genomic island (SGI1) and in 11.5% by the InH-like integron (bla OXA-30–aadA1) and catA1, sul1, and tet(B) genes. STYMXB.0061 (75%) and DT120 (84.6%) were the prevalent pulsotype and phage type identified in these strains, respectively. Five other resistance patterns were found either in single or in a low number of isolates. The pandemic clone DT104 (ACSSuT encoded by SGI1) has been identified in Italy since 1992, while strains DT120 (ACSSuT encoded by SGI1) have never been previously reported in Italy. In Europe, clinical strains DT120 have been reported from sporadic outbreaks linked to the consumption of pork products. However, none of these strains were STYMXB.0061 and SGI1 positive. The prevalent identification and persistence of DT120 isolates would suggest, in Southern Italy, a phage type shifting of the pandemic DT104 clone pulsotype STYMXB.0061. Additionally, these findings raise epidemiological concern about the potential diffusion of these emerging multidrug resistant (SGI linked) DT120 strains.
Description of a partial Dromiceiomimus (Dinosauria: Theropoda) skeleton with comments on the validity of the genus

Dromiceiomimus brevitertius is a North American ornithomimid diagnosed primarily by the ratio of tibia length to femur length. It has recently, and perhaps incorrectly, been considered synonymous with Ornithomimus edmontonicus, with several authors questioning the utility of limb ratios in diagnosing taxa. While isolated ornithomimosaur material is common, specimens with sufficient diagnostic material to explore the question of synonymy are comparatively rare. The putative Dromiceiomimus specimen UALVP 16182 represents one of the few specimens in which diagnostic elements are available. It is therefore an important specimen for assessing the validity of Dromiceiomimus and for examining the utility of using limb proportions to diagnose ornithomimid taxa. In this paper, UALVP 16182 is described, the tibia/femur ratio is examined in closely related ornithomimid taxa, and the ratio is found to distinguish Dromiceiomimus from Gallimimus, Ornithomimus, and Struthiomimus. A phylogenetic analysis recovered Anserimimus and Ornithomimus as sister taxa with Dromiceiomimus as an outgroup. Comparison of the manus revealed differences in the morphology of metacarpal I and the flexor tubercle of manual ungual II-3. Differences also appear in the surangular and scapula. An examination of stratigraphic positions of various specimens indicates that Dromiceiomimus is generally higher in section than Ornithomimus, although there are too few specimens to be statistically significant. This study agrees with other studies in concluding that limb proportions are roughly isometric in small theropods like ornithomimids and that the tibia/femur ratio may therefore be useful for diagnosing certain small taxa. These findings suggest that Dromiceiomimus may indeed be a valid taxon.
A symmetrical two-mass vocal-fold model coupled to vocal tract and trachea, with application to prosthesis design

We propose a two-mass model for the vocal folds. The aerodynamic force resulting from the air flow through the glottis is distributed over both masses, as opposed to some earlier models in which the force is allocated to the upstream mass only. This allows the choice of a symmetrical vocal-fold structure, with two identical mass-spring systems. The number of mechanical parameters is thus reduced. Their choice is inspired upon analysis of the eigenmodes of the actual vocal folds. The new aerodynamic force distribution allows acoustic feedback from vocal tract and trachea to be considered; sub- and supra-glottal systems are modelled as transmission lines. The flow model includes a simple flow-separation description. Parameter values are based on physiological measurements and calculations reported in literature. However, as in any vocal-fold model it is inevitable that parameters also partly make up for simplifications in the model. The model predictions are shown to compare well to in-vivo experimental data from literature concerning acoustic feedback. The two-mass model is applied to study the effect of size and position of a vocal-fold prosthesis on its performance. We indicate how the model should be modified to provide order-of-magnitude estimates of the effect of flow inertia and fluid viscosity. The described improvement of the flow model is not of predictive value within the framework of the simplified mechanical model we propose.
The Longevity of Baseball Hall of Famers Compared to Other Players

ABSTRACT The authors compared the longevity of all baseball players alive at the time of their induction into the Baseball Hall of Fame with age-matched controls who were likewise alive at the time of the Hall of Famer's induction, and also matched them for career length, player position, and body-mass index, to assess if fame in sports is associated with increased longevity. Median post-induction survival for Hall of Famers was 5 years shorter than for noninducted players (18 vs. 23 years, respectively). In a second analysis, significantly more Hall of Famers died of cardiovascular or stroke causes than other players for whom cause of death was known. Baseball fame may have a hitherto unrecognized price.
Thermotolerant and mesophylic fungi from sugarcane bagasse and their prospection for biomass-degrading enzyme production

Nineteen fungi and seven yeast strains were isolated from sugarcane bagasse piles from an alcohol plant located at Brazilian Cerrado and identified up to species level on the basis of the gene sequencing of 5.8S-ITS and 26S ribosomal DNA regions. Four species were identified: Kluyveromyces marxianus, Aspergillus niger, Aspergillus sydowii and Aspergillus fumigatus, and the isolates were screened for the production of key enzymes in the saccharification of lignocellulosic material. Among them, three strains were selected as good producers of hemicellulolitic enzymes: A. niger (SBCM3), A. sydowii (SBCM7) and A. fumigatus (SBC4). The best β-xylosidase producer was A. niger SBCM3 strain. This crude enzyme presented optimal activity at pH 3.5 and 55 °C (141 U/g). For β-glucosidase and xylanase the best producer was A. fumigatus SBC4 strain, whose enzymes presented maximum activity at 60 °C and pH 3.5 (54 U/g) and 4.0 (573 U/g), respectively. All these crude enzymes presented stability around pH 3.0–8.0 and up to 60 °C, which can be very useful in industrial processes that work at high temperatures and low pHs. These enzymes also exhibited moderate tolerance to ethanol and the sugars glucose and xylose. These similar characteristics among these fungal crude enzymes suggest that they can be used synergistically in cocktails in future studies of biomass conversion with potential application in several biotechnological sectors.
Application of a droplet evaporation model to aerodynamic size measurement of drug aerosols generated by a vibrating mesh nebulizer.

BACKGROUND Droplet evaporation has been known to bias cascade impactor measurement of aerosols generated by jet nebulizers. Previous work suggests that vibrating mesh nebulizers behave differently from jet nebulizers. Unlike jet nebulizers, vibrating mesh nebulizers do not rely on compressed air to generate droplets. However, entrained air is still required to transport the generated droplets through the cascade impactor during measurement. The mixing of the droplet and entrained air streams, and heat and mass transfer occurring downstream determines the final aerosol size distribution actually measured by the cascade impactor. This study is aimed at quantifying the effect of these factors on droplet size measurements for the case of vibrating mesh nebulizers. METHODS A simple droplet evaporation model has been applied to investigate aerodynamic size measurement of drug aerosol droplets produced by a proprietary vibrating mesh nebulizer. The droplet size measurement system used in this study is the Next Generation Impactor (NGI) cascade impactor. Comparison of modeling results with experiment indicates that droplet evaporation remains a significant effect when sizing aerosol generated by a vibrating mesh nebulizer. RESULTS AND CONCLUSIONS Results from the droplet evaporation model shows that the mass median aerodynamic diameter (MMAD) measured by the NGI is strongly influenced not only by the initial droplet size, but also by factors such as the temperature and humidity of entrained air, the nebulizer output rate, and the entrained air flow rate. The modeling and experimental results indicate that the influence of these variables on size measurements may be reduced significantly by refrigerating the impactor down to 5°C prior to measurement. The same data also support the conclusion that for the case of nebulized drug solutions, laser diffraction spectrometry provides a meaningful droplet sizing approach, that is simpler and less susceptible to such droplet evaporation artifacts.
The RNA Chaperone Hfq Is Involved in Stress Tolerance and Virulence in Uropathogenic Proteus mirabilis

Hfq is a bacterial RNA chaperone involved in the riboregulation of diverse genes via small noncoding RNAs. Here, we show that Hfq is critical for the uropathogenic Proteus mirabilis to effectively colonize the bladder and kidneys in a murine urinary tract infection (UTI) model and to establish burned wound infection of the rats. In this regard, we found the hfq mutant induced higher IL-8 and MIF levels of uroepithelial cells and displayed reduced intra-macrophage survival. The loss of hfq affected bacterial abilities to handle H2O2 and osmotic pressures and to grow at 50°C. Relative to wild-type, the hfq mutant had reduced motility, fewer flagella and less hemolysin expression and was less prone to form biofilm and to adhere to and invade uroepithelial cells. The MR/P fimbrial operon was almost switched to the off phase in the hfq mutant. In addition, we found the hfq mutant exhibited an altered outer membrane profile and had higher RpoE expression, which indicates the hfq mutant may encounter increased envelope stress. With the notion of envelope disturbance in the hfq mutant, we found increased membrane permeability and antibiotic susceptibilities in the hfq mutant. Finally, we showed that Hfq positively regulated the RpoS level and tolerance to H2O2 in the stationary phase seemed largely mediated through the Hfq-dependent RpoS expression. Together, our data indicate that Hfq plays a critical role in P. mirabilis to establish UTIs by modulating stress responses, surface structures and virulence factors. This study suggests Hfq may serve as a scaffold molecule for development of novel anti-P. mirabilis drugs and P. mirabilis hfq mutant is a vaccine candidate for preventing UTIs.
New Coupled Codes Constructed by Overlapping Circular SC-LDPC Codes

In this paper, we propose new coupled codes constructed by overlapping circular spatially-coupled low-density parity-check (SC-LDPC) codes, which show better asymptotic and finite-length decoding performance compared to the conventional SC-LDPC codes. The performance improvement comes from the property that the proposed codes effectively split into two separated SC-LDPC codes with shorter chain length during the decoding process. We verify that the property of the proposed codes is valid in asymptotic setting via analysis tools such as the density evolution and the expected graph evolution. Experimental results show that the proposed codes also outperform the conventional SC-LDPC codes in terms of the finite-length performance under belief propagation decoding.
Present and future schistosomiasis control activities with support from the Schistosomiasis Control Initiative in West Africa

SUMMARY Since 2004 the West African countries of Burkina Faso, Mali and Niger have implemented national schistosomiasis and soil-transmitted helminthiasis control programmes with financial and technical support from the Schistosomiasis Control Initiative (SCI). In the first three years of the control programmes, nearly 13·5 million doses of praziquantel and albendazole have been administered against schistosomiasis and soil-transmitted helminthiasis with coverage rates varying between 67·0% and 93·9%. These treatments have resulted in a reduction of the prevalence and intensity of Schistosoma infection in the sentinel cohorts that were set up to monitor and evaluate the national control programmes. The challenges currently faced by these national control programmes are the ability to maintain the reduction in morbidity achieved thus far due to the mass treatment campaigns and ensuring sustainability. For reinforcement of surveillance, the establishment of a geographical information system is suggested in order to contribute towards enhanced sustainability of these programmes. Our new working hypothesis is that targeted control accompanied by periodic mass treatment campaigns (every two to three years) can contribute to maintaining the low levels of morbidity achieved thus far. The implementation of integrated neglected tropical disease control programmes in these countries will provide means to ensure the financial sustainability of control activities for the years to come.
The Relationship between Trust and Budgetary Slack : an Empirical Study

The budgetary slack has been studied extensively in the management and accounting literature, but results are inconclusive. This could be because the research has focused on economic factors rather than on psychological variables, such as trust. This paper tries to contrast psychological and economic causes in the creation of budgetary slack. Particularly, we examine whether a higher amount of subordinates’ trust in their superiors with an economic incentive helps to reduce the tendency of subordinates to create budgetary slack. This study is based on a laboratory experiment conducted with 240 managers in order to investigate how trust, understood as a psychological and moral factor, contributes toward the reduction of slack in the absence and presence of pecuniary incentives. Subjects were divided into three groups: managers, executives and controller. Results support partially our hypotheses. This paper shows that non-monetary incentives could help managers to reduce budgetary slack in organizations.
The Proline-Rich Homeodomain (PRH/HEX) Protein Is Down-Regulated in Liver during Infection with Lymphocytic Choriomeningitis Virus

ABSTRACT The proline-rich homeodomain protein, PRH/HEX, participates in the early development of the brain, thyroid, and liver and in the later regenerative processes of damaged liver, vascular endothelial, and hematopoietic cells. A virulent strain of lymphocytic choriomeningitis virus (LCMV-WE) that destroys hematopoietic, vascular, and liver functions also alters the transcription and subcellular localization of PRH. A related virus (LCMV-ARM) that does not cause disease in primates can infect cells without affecting PRH. Biochemical experiments demonstrated the occurrence of binding between the viral RING protein (Z) and PRH, and genetic experiments mapped the PRH-suppressing phenotype to the large (L) segment of the viral genome, which encodes the Z and polymerase genes. The Z protein is clearly involved with PRH, but other viral determinants are needed to relocate PRH and to promote disease. By down-regulating PRH, the arenavirus is able to eliminate the antiproliferative effects of PRH and to promote liver cell division. The interaction of an arenavirus with a homeodomain protein suggests a mechanism for viral teratogenic effects and for the tissue-specific manifestations of arenavirus disease.
The Effect of Minimum Wages on Immigrants

This study compares the effects of minimum wage laws on employment and earnings among low-skilled immigrants and natives in the U.S. Conventional economic theory predicts that higher minimum wages lead to higher earnings among the employed but lower employment rates. Minimum wage increases might have larger effects among low-skilled immigrants than among natives because, on average, immigrants earn less than natives due to lower levels of education, limited English skills, and less social capital. We use data from the Current Population Survey during 1994-2005 to examine how minimum wages at the federal and state level are related to employment-to-population rates, average hours worked, and average hourly earnings among nativeand foreign-born adults who do not have a high school diploma. Our results do not indicate that minimum wages have adverse employment effects among low-skilled immigrants or natives. Higher minimum wages may discourage settlement by low-skilled immigrants, however, while most low-skilled adult natives earn too much to be directly affected by minimum wage laws in recent years. JEL classifications: J23, J38, J15
Spatial Variability of Soil Moisture and the Scale Issue: A Geostatistical Approach

We study the standard deviation of water saturation SDS as function of the mean saturation 〈S〉 by a stochastic model of unsaturated flow, which is based on the first‐order solution of the three‐dimensional Richards equation. The model assumes spatially variable soil properties, following a given geostatistical description, and it explicitly accounts for the different scales involved in the determination of the spatial properties of saturation: the extent L, i.e., the domain size, the spacing Δ among measurements, and the dimension ℓ associated to the sampling measurement. It is found that the interplay between those scales and the correlation scale I of the hydraulic properties rules the spatial variability of saturation. A “scale effect” manifests for small to intermediate L/I, for which SDS increase with the extent L. This nonergodic effect depends on the structural and hydraulic parameters as well as the scales of the problem, and it is consistent with a similar effect found in field experiments. In turn, the influence of the scale ℓ is to decrease the saturation variability and increase its spatial correlation. Although the solution focuses on the medium heterogeneity as the main driver for the spatial variability of saturation, neglecting other important components, it explicitly links the spatial variation of saturation to the hydraulic properties of the soil, their spatial variability, and the sampling schemes; it can provide a useful tool to assess the impact of scales on the saturation variability, also in view of the several applications that involve the saturation variability.
Animating reactive motion using momentum‐based inverse kinematics

Interactive generation of reactive motions for virtual humans as they are hit, pushed and pulled are very important to many applications, such as computer games. In this paper, we propose a new method to simulate reactive motions during arbitrary bipedal activities, such as standing, walking or running. It is based on momentum based inverse kinematics and motion blending. When generating the animation, the user first imports the primary motion to which the perturbation is to be applied to. According to the condition of the impact, the system selects a reactive motion from the database of pre‐captured stepping and reactive motions. It then blends the selected motion into the primary motion using momentum‐based inverse kinematics. Since the reactive motions can be edited in real‐time, the criteria for motion search can be much relaxed than previous methods, and therefore, the computational cost for motion search can be reduced. Using our method, it is possible to generate reactive motions by applying external perturbations to the characters at arbitrary moment while they are performing some actions. Copyright © 2005 John Wiley & Sons, Ltd.
Decreased Cognitive Function in Extended Family Members from the Single Late-Onset-Alzheimer's-Disease Pedigree

Abstract A family history of dementia is associated with an increased risk of developing Alzheimer's disease (AD) late in life (LOAD). This study marked the first attempt to assess the familial contribution to differences in cognitive performance in a large family-based group in the Chinese community. We enrolled 168 participants without dementia from a single pedigree with 9 probable AD patients diagnosed after age 65. These participants were evaluated with a comprehensive neuropsychological battery, the Chinese version of the Mini Mental State Examination, and the Alzheimer Disease Assessment Scale–Cognitive Subscale. Analyses found that extended family members of the LOAD pedigree showed similar performance on measures of global cognitive function and semantic memory compared to controls, but lower scores on episodic memory, attention, and executive function measures. These results indicate that the genetic influences on certain sub-cognitive domains are more detectable despite normal global cognitive function, and that family members with the LOAD pedigree are at risk for developing LOAD by virtue of their family history with an additive risk due to increased age. The findings in this study support the importance of documenting if there is a positive family history of AD in clinical evaluations. (JINS, 2013, 19, 1–11)