Miracle-dz/UniFAR-FTUs huggingface dataset:
Induction of remission in active anti-neutrophil cytoplasmic antibody-associated vasculitis with mycophenolate mofetil in patients who cannot be treated with cyclophosphamide

Background: Active anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) is commonly treated with cyclophosphamide, a drug with serious side effects, and with corticosteroids. Objective: To determine the efficacy of a possible alternative drug for cyclophosphamide, oral mycophenolate mofetil (MMF) 1000 mg twice daily and oral prednisolone 1 mg/kg once daily as remission induction treatment. Methods: 32 consecutive patients with 34 episodes of active vasculitis who could not be treated with cyclophosphamide were diagnosed for a median (range) of 6.0 (0.3–22) years and experienced 4 (0–14) relapses prior to the current episode. Treatment response and relapse-free survival were analysed. Results: Complete remission (CR) was obtained in 25 (78%) patients, partial remission (PR) in 6 (19%), whereas 1 (3%) patient did not respond. 19 patients relapsed, 13 (52%) after CR, 14 (3–58) months after starting the treatment and 6 (100%) after PR, 6 (2–10) months after starting the treatment. The median relapse-free survival was 16 months, comparable with the interval between the previous relapse and the current MMF-treated relapse (17 (3–134) months). Relapse-free survival at 1, 3, and 5 years was 63%, 38% and 27%, respectively. Patients who had been treated successfully with cyclophosphamide before responded better (CR 84%, relapse 50%) than those who had not (CR 50%, relapse 100%). Minor gastrointestinal side effects and infections occurred frequently. MMF was prematurely discontinued due to adverse effects in two patients. Conclusion: MMF, in combination with prednisolone, can induce remission in patients with relapses of AAV intolerant to cyclophosphamide.
A new tricarbonylrhenium(I) compound incorporating the tridentate ligand N,N-bispicolyl-2-ethanolamine.

The title compound, {[N,N-bis(2-pyridylmethyl)amino]ethanol-kappa(3)N,N',N''}tricarbonylrhenium(I) bromide methanol solvate, [Re(C14H17N3O)(CO)3]Br.CH4O, has been prepared in almost quantitative yield by reacting (NEt4)2[Re(CO)3Br3] with the ligand N,N-bispicolyl-2-ethanolamine in refluxing methanol. The X-ray structure revealed that the Re(CO)3N3 coordination sphere is highly distorted from octahedral geometry and that the Re(CO)3 core is facial. The coordinated ligand forms two five-membered rings, with the pyridine rings in a butterfly formation. The OH group is not involved in metal coordination. The packing of the molecule shows a network of classical O.H-O and Br.H-O, and non-classical Br.H-C and O.H-C hydrogen bonds between the methanol solvate molecules, the metal complex cations and the bromide anions.
On-field testing environment and balance error scoring system performance during preseason screening of healthy collegiate baseball players.

CONTEXT To determine if testing environment affects Balance Error Scoring System (BESS) scores in healthy collegiate baseball players. DESIGN Experimental, randomized, repeated-measures design with a sample of convenience. SETTING Uncontrolled sideline and controlled locker room baseball environments. PATIENTS OR OTHER PARTICIPANTS A total of 21 healthy collegiate baseball players (age = 20.1 +/- 1.4 years, height = 185.1 +/- 6.8 cm, mass = 86.3 +/- 9.5 kg) with no history of head injury within the last 12 months, no lower extremity injuries reported within the past 2 months that caused them to miss 1 or more days of practice or game time, and no history of otitis media, Parkinson disease, or Meniere disease. MAIN OUTCOME MEASURE(S) Participants performed the BESS test in 2 environments, controlled locker room and uncontrolled sideline, in 2 testing sessions 1 week apart during the baseball preseason. The BESS scores were evaluated for each of the 6 conditions and total score across the testing sessions. Separate, paired-samples t tests with Bonferroni adjustment (P < .008) were used to examine differences between testing environments for each BESS subcategory and total score. Cohen d tests were calculated to evaluate effect sizes and relative change. RESULTS Significant group mean differences were found between testing environments for single-leg foam stance (P = .001), with higher scores reported for the uncontrolled sideline environment (7.33 +/- 2.11 errors) compared with the controlled clinical environment (5.19 +/- 2.16 errors). Medium to large effect sizes (0.53 to 1.03) were also found for single-leg foam, tandem foam, and total BESS scores, with relative increases (worse scores) of 30% to 44% in the sideline environment compared with the clinical environment. CONCLUSIONS The BESS performance was impaired when participants were tested in a sideline environment compared with a clinical environment. Baseline testing for postural control using the BESS should be conducted in the setting or environment in which testing after injury will most likely be conducted.
2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes—2018

The American Diabetes Association (ADA) “Standards of Medical Care in Diabetes” includes ADA’s current clinical practice recommendations and is intended to provide the components of diabetes care, general treatment goals and guidelines, and tools to evaluate quality of care. Members of the ADA Professional Practice Committee, a multidisciplinary expert committee, are responsible for updating the Standards of Care annually, or more frequently as warranted. For a detailed description of ADA standards, statements, and reports, as well as the evidence-grading system for ADA’s clinical practice recommendations, please refer to the Standards of Care Introduction. Readers who wish to comment on the Standards of Care are invited to do so at professional.diabetes. org/SOC.
Comprehensive Molecular Analysis of NSCLC; Clinicopathological Associations

Background Selection of NSCLC patients for targeted therapy is currently based upon the presence of sensitizing mutations in EGFR and EML4/ALK translocations. The heterogeneity of molecular alterations in lung cancer has led to the ongoing discovery of potential biomarkers and targets in order to improve survival. Aim This study aimed to detect alterations in EGFR, KRAS, BRAF, PIK3CA, MET-gene copy number and ALK rearrangements in a large cohort of 956 NSCLC patients of Hellenic origin using highly sensitive techniques and correlations with clinicopathological characteristics. Results Mutations were detected in EGFR 10.6% (101 out of 956 samples), KRAS 26.5% (191 out of 720 samples), BRAF 2.5% (12 out of 471 samples), PIK3CA 3.8% (7 out of 184 samples), MET gene amplification was detected in 18% (31 out of 170) and ALK rearrangements in 3.7% (4 out of 107 samples). EGFR mutations were detected in exon 19 (61.4% of mutant cases), exon 21 p.Leu858Arg (19.8%), exon 20 (15.8%), exon 18 (2.9%) and were correlated with gender histology, smoking status and TTF1 staining. p.Thr790Met mutant cases (3.9%) displayed concurrent mutations in exons 19 or 21. Negative TTF-1 staining showed strong negative predictive value for the presence of EGFR mutations. KRAS mutations were associated with histology, the most common mutation being p.Gly12Cys (38%). Discussion In conclusion, only 89 patients were eligible for EGFR -TKIs and ALK inhibitors therapy, whereas 257 patients showed other alterations, highlighting the necessity for a detailed molecular profiling potentially leading to more efficient individualized therapies for NSCLC patients.
Assessing Achievability of Queries and Constraints

Assessing and improving the quality of data in data-intensive systems are fundamental challenges that have given rise to numerous applications targeting transformation and cleaning of data. However, while schema design, data cleaning, and data migration are nowadays reasonably well understood in isolation, not much attention has been given to the interplay between the tools that address issues in these areas. Our focus is on the problem of determining whether there exist sequences of data-transforming procedures that, when applied to the (untransformed) input data, would yield data satisfying the conditions required for performing the task in question. Our goal is to develop a framework that would address this problem, starting with the relational setting. In this paper we abstract data-processing tools as black-box procedures. This abstraction describes procedures by a specification of which parts of the database might be modified by the procedure, as well as by the constraints that specify the required states of the database before and after applying the procedure. We then proceed to study fundamental algorithmic questions arising in this context, such as understanding when one can guarantee that sequences of procedures apply to original or transformed data, when they succeed at improving the data, and when knowledge bases can represent the outcomes of procedures. Finally, we turn to the problem of determining whether the application of a sequence of procedures to a database results in the satisfaction of properties specified by either queries or constraints. We show that this problem is decidable for some broad and realistic classes of procedures and properties, even when procedures are allowed to alter the schema of instances.
The Aponeurotic Tension Model of Craniofacial Growth in Man

Craniofacial growth is a scientific crossroad for the fundamental mechanisms of musculoskeletal physiology. Better understanding of growth and development will provide new insights into repair, regeneration and adaptation to applied loads. Traditional craniofacial growth concepts are insufficient to explain the dynamics of airway/vocal tract development, cranial rotation, basicranial flexion and the role of the cranial base in expression of facial proportions. A testable hypothesis is needed to explore the physiological pressure propelling midface growth and the role of neural factors in expression of musculoskeletal adaptation after the cessation of anterior cranial base growth. A novel model for craniofacial growth is proposed for: 1. brain growth and craniofacial adaptation up to the age of 20; 2. explaining growth force vectors; 3. defining the role of muscle plasticity as a conduit for craniofacial growth forces; and 4. describing the effect of cranial rotation in the expression of facial form. Growth of the viscerocranium is believed to be influenced by the superficial musculoaponeurotic systems (SMAS) of the head through residual tension in the occipitofrontalis muscle as a result of cephalad brain growth and cranial rotation. The coordinated effects of the regional SMAS develop a craniofacial musculoaponeurotic system (CFMAS), which is believed to affect maxillary and mandibular development.
The effect of pseudo-accumulation in the measurement of fatigue laser-induced damage threshold

Laser-induced damage threshold determination as a function of the number of incident pulses on a specific optic is a classic problem in laser damage studies. There are several models of the fundamental mechanisms explaining the fatigue laser damage behavior including temperature accumulation and changes of electronic or chemical material structure. Herewith we discuss the effects of unstable laser radiation on S-on-1 laser-induced damage probability. Numerical simulations of S-on-1 measurements for specific cases of defect densities, spot sizes and beam jitters are performed. It is demonstrated that the statistical effects of "pseudo-accumulation" reasoned by unstable laser radiation in transparent dielectrics containing nanometer sized defects leads to accumulation-like behavior. The magnitudes of the random beam walking and the energy fluctuations are directly related to the damage probability. Experimental results are also introduced to illustrate the theoretical results.
Electrophysiological Consequences of Dyssynchronous Heart Failure and Its Restoration by Resynchronization Therapy

Background— Cardiac resynchronization therapy (CRT) is widely applied in patients with heart failure and dyssynchronous contraction (DHF), but the electrophysiological consequences of CRT in heart failure remain largely unexplored. Methods and Results— Adult dogs underwent left bundle-branch ablation and either right atrial pacing (190 to 200 bpm) for 6 weeks (DHF) or 3 weeks of right atrial pacing followed by 3 weeks of resynchronization by biventricular pacing at the same pacing rate (CRT). Isolated left ventricular anterior and lateral myocytes from nonfailing (control), DHF, and CRT dogs were studied with the whole-cell patch clamp. Quantitative polymerase chain reaction and Western blots were performed to measure steady state mRNA and protein levels. DHF significantly reduced the inward rectifier K+ current (IK1), delayed rectifier K+ current (IK), and transient outward K+ current (Ito) in both anterior and lateral cells. CRT partially restored the DHF-induced reduction of IK1 and IK but not Ito, consistent with trends in the changes in steady state K+ channel mRNA and protein levels. DHF reduced the peak inward Ca2+ current (ICa) density and slowed ICa decay in lateral compared with anterior cells, whereas CRT restored peak ICa amplitude but did not hasten decay in lateral cells. Calcium transient amplitudes were depressed and the decay was slowed in DHF, especially in lateral myocytes. CRT hastened the decay in both regions and increased the calcium transient amplitude in lateral but not anterior cells. No difference was found in CaV1.2 (α1C) mRNA or protein expression, but reduced CaVβ2 mRNA was found in DHF cells. DHF reduced phospholamban, ryanodine receptor, and sarcoplasmic reticulum Ca2+ ATPase and increased Na+-Ca2+ exchanger mRNA and protein. CRT did not restore the DHF-induced molecular remodeling, except for sarcoplasmic reticulum Ca2+ ATPase. Action potential durations were significantly prolonged in DHF, especially in lateral cells, and CRT abbreviated action potential duration in lateral but not anterior cells. Early afterdepolarizations were more frequent in DHF than in control cells and were reduced with CRT. Conclusions— CRT partially restores DHF-induced ion channel remodeling and abnormal Ca2+ homeostasis and attenuates the regional heterogeneity of action potential duration. The electrophysiological changes induced by CRT may suppress ventricular arrhythmias, contribute to the survival benefit of this therapy, and improve the mechanical performance of the heart.
Mavrilimumab: an evidence based review of its potential in the treatment of rheumatoid arthritis

Rheumatoid arthritis (RA) management has greatly improved with the development of biologic disease modifying antirheumatic drugs, but a proportion of patients do not improve despite the biologic drugs currently available. We need new biologic agents with novel mechanisms of action for the treatment of refractory patients. Recent evidence has shown that granulocyte-macrophage colony-stimulating factor (GM-CSF) is involved in the pathogenesis of RA. GM-CSF can exacerbate RA and elevated levels of this cytokine have been observed in synovial fluid from RA patients. Antagonism of GM-CSF can strikingly reduce established disease in mouse models of arthritis. Mavrilimumab, a human monoclonal antibody to GM-CSF receptor α, is a competitive antagonist of GM-CSF signaling. Phase I and II studies have shown good clinical response with a good safety profile in patients with mild to moderate RA, suggesting encouraging effects of mavrilimumab for the treatment of RA. This paper reviews the preclinical and clinical data evaluating the safety, tolerability, and efficacy of mavrilimumab in the treatment of RA.
Dissolution-Segregation Behavior of Ca during the Sintering Process of MnZn Ferrite

Dissolution and segregation behavior of Ca in the Sintering process of MnZn ferrite were investigated by microstructure analysis. It was revealed that, as the temperature rises to above 1000°C, Ca dissolves to the spinel lattice and disperses uniformly in the ferrite at the soaking step. Ca begins to segregate to the grain boundaries in the slow cooling process, and the segregation proceeds below 1100°C rather than above. This suggests that control of the cooling in this temperature range is of great importance for the formation of high-resistivity grain boundaries and the lowering of core loss.
Monitoring of insecticides resistance in main malaria vectors in a malarious area of Kahnooj district, Kerman province, southeastern Iran.

BACKGROUND AND OBJECTIVES Kahnooj district in south of Iran is an endemic area for malaria where Anopheles stephensi (Liston) is a main malaria vector and An. dthali (Patton) a secondary vector. According to the national strategy plan on monitoring of insecticides resistance, this study was performed on susceptibility and irritability levels of An. stephensi and An. dthali to different insecticides in the district. METHODS The susceptibility and irritability levels of field strains of An. stephensi and An. dthali at the adult and larval stages to discriminative dose of different imagicides was determined as recommended by WHO. RESULTS Using discriminative dose and WHO criteria it was found that An. stephensi is resistant to DDT and dieldrin with 36.1 +/- 2.3 and 62.2 +/- 1.95 mortality rates, respectively; but susceptible to other insecticides. An. dthali was found to susceptible to all tested insecticides. The larvae of An. stephensi, exhibited 100% mortality for temephos and malathion, but 44 +/- 4.32 for discriminative dose of fenitrothion. The results of irritability level for DDT and pyrethroids showed that permethrin had the most irritancy effect on An. stephensi and An. dthali. DDT and deltamethrin showed the least irritancy effect against An. stephensi with 0.42 +/- 0.08 and 0.77 +/- 0.12 take-offs/min/adult, respectively, however, lambdacyhalothrin had the least irritancy effect against An. dthali with 0.096 +/- 0.02 take-offs/min/ adult. The mean number of take-offs/min/adult with permethrin showed significant difference to DDT, lambdacyhalothrin, cyfluthrin and deltamethrin. INTERPRETATION AND CONCLUSION Pyrethroid insecticides are being used as indoor residual sprays in Iran. Based on our results, the main malaria vectors in the region are still susceptible to pyrethroid insecticides. Therefore, we propose the use of pyrethroids with low irritancy effect in rotation with carbamate insecticides in two interval seasonal peaks of malaria transmission. Biological control including larvivorous fishes, using of local made Bacillus thuringiensis and larvicides such as chlorpyrifos-methyl are the main larval control in the region. Result on larval test exhibited the susceptibility of main vectors to some larvicides, although the 100% mortality was not obtained using fenitrothion and this is postulated the use of this insecticide in agriculture pest control. Monitoring and evaluation of insecticides resistance in malaria vectors in the region could provide an essential clue for judicious use of insecticides.
Toughening of brittle epoxy using bitumen as a new modifier

This article describes the toughening of brittle epoxy using bitumen as a new modifier. The main objective of this study is to incorporate bitumen into epoxy matrix with the aim of obtaining an epoxy hybrid material with higher impact and fracture properties and lower cost without attenuating the other desired mechanical properties such as tensile strength. Mechanical properties of epoxy/bitumen hybrids with different bitumen contents were studied. With the addition of only 2% bitumen to epoxy, maximum improvements of 164% and 187% were obtained for impact strength and fracture resistance, respectively. The addition of bitumen to epoxy matrix had no significant effect on tensile properties. Morphological properties of the hybrid were studied by scanning electron microscopy and a dispersion of micron-sized bitumen particles in epoxy-rich matrix was obtained as main morphology. Thermogravimetric analysis of the hybrid in inert environment showed that the thermal stability decreases slightly with incorporation of bitumen into epoxy matrix. The chemical stability of the hybrid against different acids and alkalis was higher than neat epoxy but relatively lower stability was observed against organic solvents.
The Cosmic Production of Helium

We estimate the cosmic production rate of helium relative to metals (ΔY/ΔZ) using K dwarf stars in the Hipparcos catalog with accurate spectroscopic metallicities. The best fitting value is ΔY/ΔZ = 2.1 ± 0.4 at the 68% confidence level. Our derived value agrees with determinations from Hii regions and with theoretical predictions from stellar yields with standard assumptions for the initial mass function. The amount of helium in stars determines how long they live and therefore how fast they will enrich the interstellar medium with fresh material.
The Unique Brain Anatomy of Meditation Practitioners: Alterations in Cortical Gyrification

Several cortical regions are reported to vary in meditation practitioners. However, prior analyses have focused primarily on examining gray matter or cortical thickness. Thus, additional effects with respect to other cortical features might have remained undetected. Gyrification (the pattern and degree of cortical folding) is an important cerebral characteristic related to the geometry of the brain’s surface. Thus, exploring cortical gyrification in long-term meditators may provide additional clues with respect to the underlying anatomical correlates of meditation. This study examined cortical gyrification in a large sample (n = 100) of meditators and controls, carefully matched for sex and age. Cortical gyrification was established by calculating mean curvature across thousands of vertices on individual cortical surface models. Pronounced group differences indicating larger gyrification in meditators were evident within the left precentral gyrus, right fusiform gyrus, right cuneus, as well as left and right anterior dorsal insula (the latter representing the global significance maximum). Positive correlations between gyrification and the number of meditation years were similarly pronounced in the right anterior dorsal insula. Although the exact functional implications of larger cortical gyrification remain to be established, these findings suggest the insula to be a key structure involved in aspects of meditation. For example, variations in insular complexity could affect the regulation of well-known distractions in the process of meditation, such as daydreaming, mind-wandering, and projections into past or future. Moreover, given that meditators are masters in introspection, awareness, and emotional control, increased insular gyrification may reflect an integration of autonomic, affective, and cognitive processes. Due to the cross-sectional nature of this study, further research is necessary to determine the relative contribution of nature and nurture to links between cortical gyrification and meditation.