Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of inhaled fluticasone on upper airway during sleep and wakefulness in asthma: a pilot study.

STUDY OBJECTIVE Obstructive sleep apnea is prevalent among people with asthma, but underlying mechanisms remain unknown. Inhaled corticosteroids may contribute. We tested the effects of orally inhaled fluticasone propionate (FP) on upper airway (UAW) during sleep and wakefulness. STUDY DESIGN 16-week single-arm study. PARTICIPANTS 18 (14 females, mean [ ± SD] age 26 ± 6 years) corticosteroid-naïve subjects with mild asthma (FEV1 89 ± 8% predicted). INTERVENTIONS High dose (1,760 mcg/day) inhaled FP. MEASUREMENTS (1) UAW collapsibility (passive critical closing pressure [Pcrit]); (2) tongue strength (maximum isometric pressure-Pmax, in KPa) and endurance-time (in seconds) able to maintain 50% Pmax across 3 trials (Ttot)-at anterior and posterior locations; (3) fat fraction and volume around UAW, measured by magnetic resonance imaging in three subjects. RESULTS Pcrit overall improved (became more negative) (mean ± SE) (-8.2 ± 1.1 vs. -12.2 ± 2.2 cm H2O, p = 0.04); the response was dependent upon baseline characteristics, with older, male gender, and worse asthma control predicting Pcrit deterioration (less negative). Overall, Pmax increased (anterior p = 0.02; posterior p = 0.002), but Ttot generally subsided (anterior p = 0.0007; posterior p = 0.06), unrelated to Pcrit response. In subjects studied with MRI, fat fraction and volume increased by 20.6% and 15.4%, respectively, without Pcrit changes, while asthma control appeared improved. CONCLUSIONS In this study of young, predominantly female, otherwise healthy subjects with well-controlled asthma and stiff upper airways, 16-week high dose FP treatment elicited Pcrit changes which may be dependent upon baseline characteristics, and determined by synchronous and reciprocally counteracting local and lower airway effects. The long-term implications of these changes on sleep disordered breathing severity remain to be determined.
Preoperative anaemia is a risk factor for mortality and morbidity following aortic valve surgery.

OBJECTIVES The impact of anaemia on patients undergoing aortic valve surgery has not been well studied. We sought to evaluate the effect of anaemia on early outcomes following aortic valve replacement (AVR). METHODS All patients undergoing non-emergent aortic valve surgery (n = 2698) with or without other concomitant procedures between 1997 and 2010 were included. Preoperative anaemia was defined as per World Health Organization guidelines as haemoglobin (Hb) < 130 g/l in men and Hb < 120 g/l in women. Multivariable analyses were used to determine the association between preoperative anaemia and postoperative outcomes. RESULTS The prevalence of preoperative anaemia was 32.2%. Patients with anaemia were older (71 ± 12 vs 66 ± 13 years, P < 0.001), more likely to have urgent surgery, recent MI, higher creatinine level and impaired preoperative left ventricular function. Overall unadjusted mortality was 2.8% in non-anaemic patients vs 8% in anaemic patients. Anaemic patients were more likely to require renal replacement therapy (11 vs 3%, P < 0.0001) and prolonged ventilation (24 vs 10%, P < 0.0001). Following multivariable adjustment, lower preoperative Hb was an independent predictor of mortality (odds ratio 1.19, 95% CI: 1.04-1.34, P = 0.007) and composite morbidity (odds ratio 1.36, 95% CI: 1.05-1.77, P = 0.02) after AVR. Mortality and composite morbidity were significantly higher with lower levels of preoperative Hb. CONCLUSIONS Preoperative anaemia is a common finding in patients undergoing aortic valve surgery and is an important and potentially modifiable risk factor for postoperative morbidity and mortality.
Think differently: a brain orienting response to task novelty

Cognitive flexibility hinges on a readiness to direct attention to novel events, and on an ability to change one's mental set to find new solutions for old problems. Human event-related potential (ERP) studies have described a brain ‘orienting’ response to discrete novel events, marked by a frontally distributed positive potential peaking 300–400 ms post-stimulus (P3a). This brain potential has been typically related to bottom-up processing of novel non-targets under a fixed task-set (i.e., press a button to coloured targets), but had never been related to top-down attention control in dual-task paradigms. In this study, 27 subjects had their ERPs measured while they performed a version of the Wisconsin card sorting test (WCST), a dual-task paradigm where the same feedback cue signalled unpredictable shifts to a new task set (i.e., from ‘sort by colour’ to ‘sort by shape’). Feedback cues that directed a shift in the subject's mental set to a new task-set elicited frontally distributed P3a activity, thus suggesting a role of the P3a response system in task-set shifting. Feedback cues also evoked a longer latency positive potential (350–600 ms; P3b), that was larger the more task rules were held in memory. In line with current models of prefrontal function in the executive control of attention, this P3a/P3b response system appears to reflect the co-ordinated action of prefrontal and posterior association cortices during the switching and updating of task sets in working memory.
The value of venous oximetry

Purpose of reviewMaintenance of adequate tissue oxygenation is an important task in intensive care units. In this context, venous oximetry by obtaining mixed venous oxygen saturation or central venous oxygen saturation has been discussed as useful monitoring parameters. This review discusses the physiology and clinical application of these parameters. Recent findingsNo study has so far demonstrated that venous oxygen saturation monitoring can reduce mortality in critically ill patients although length of stay has been decreased in cardiac surgery patients. Furthermore, pulmonary artery catheter usage does not affect outcome in critically ill patients. In contrast, early goal directed therapy for patients with severe sepsis or septic shock, which includes treatment goals for mean arterial pressure, central venous pressure, and central venous oxygen saturation, was able to increase survival in these patients. There is also evidence that central venous oxygen saturation measurement is beneficial in other types of shock. SummaryEarly goal directed therapy should be implemented in the initial resuscitation of septic patients. Measurement of central venous oxygen saturation can easily be applied in intensive care unit patients and offers a useful indirect indicator for the adequacy of tissue oxygenation.
Can Bilateral Trade Agreements Help Induce Free Trade

There has been growing debate about whether bilateral trade agreements are damaging multilateral efforts to eliminate barriers to international trade. This paper develops a model in which trading blocs always charge optimal tariffs and make trade agreements based on strategic considerations. We ask a very simple question. Does the fact that trading blocs can form bilateral trade agreements make Free trade less likely to occur? The answer is that it depends on the size distribution of the trading blocs. If there is one large trading bloc along with some smaller ones then bilateral trade agreements allow the smaller trading blocs to coalesce and block the monopoly power of large trading blocs. In this case, bilateral trade agreements facilitate the attainment of free trade. Not allowing customs unions leads to more not less protection. If trading blocs are of roughly equivalent size then bilateral trade agreements allow groups of trading blocs to more effectively monopolize world trade in which case they may make free trade less likely. These results suggest that a policy that inhibits the formation of trading blocs may be harmful. We also compute the welfare effects of trade agreements to get some idea of how empirically important these issues are.
Music Exposure and the Development of Spatial Intelligence in Children.

A serious challenge facing music cognition researchers is the problem of how to fit the discipline into traditional theories of child development, theories that do not easily account for the huge range of reasoning and behaviors used by people performing musical activities. In Frames of Mind, Howard Gardner (1983) has drawn from a wide body of knowledge to provide us with a new framework for thinking about cognition a framework that holds a special place for music. Musical ability is seen as its own discrete domain of intelligence, not particularly associated with linguistic, mathematical, or spatial intelligence. However, despite the fact that music appears to be a distinct area of learning that may be unrelated to other developmental accomplishments of young children, musical abilities and certain spatial abilities do seem to be allied. It seems that musical experiences, perhaps due to neurophysiological mechanisms, can help develop a small but important facet of spatial ability in adults, children, and even in rats. This paper presents my colleagues' and my recent research on the effects of music instruction on a specific type of spatial reasoning, spatial-temporal reasoning, in children.
eIF 2 A mediates translation of hepatitis C viral mRNA under stress conditions

Translation of most mRNAs is suppressed under stress conditions. Phosphorylation of the a-subunit of eukaryotic translation initiation factor 2 (eIF2), which delivers initiator tRNA (Met-tRNAi) to the P site of the 40S ribosomal subunit, is responsible for such translational suppression. However, translation of hepatitis C viral (HCV) mRNA is refractory to the inhibitory effects of eIF2a phosphorylation, which prevents translation by disrupting formation of the eIF2–GTP–Met-tRNAi ternary complex. Here, we report that eIF2A, an alternative initiator tRNA-binding protein, has a key role in the translation of HCV mRNA during HCV infection, in turn promoting eIF2a phosphorylation by activating the eIF2a kinase PKR. Direct interaction of eIF2A with the IIId domain of the HCV internal ribosome entry site (IRES) is required for eIF2A-dependent translation. These data indicate that stress-independent translation of HCV mRNA occurs by recruitment of eIF2A to the HCV IRES via direct interaction with the IIId domain and subsequent loading of Met-tRNAi to the P site of the 40S ribosomal subunit. The EMBO Journal (2011) 30, 2454–2464. doi:10.1038/ emboj.2011. 146; Published online 10 May 2011 Subject Categories: proteins; microbiology & pathogens
Theoretical Basis, Experimental Design, and Computerized Simulation of Synergism and Antagonism in Drug Combination Studies

The median-effect equation derived from the mass-action law principle at equilibrium-steady state via mathematical induction and deduction for different reaction sequences and mechanisms and different types of inhibition has been shown to be the unified theory for the Michaelis-Menten equation, Hill equation, Henderson-Hasselbalch equation, and Scatchard equation. It is shown that dose and effect are interchangeable via defined parameters. This general equation for the single drug effect has been extended to the multiple drug effect equation for n drugs. These equations provide the theoretical basis for the combination index (CI)-isobologram equation that allows quantitative determination of drug interactions, where CI < 1, = 1, and > 1 indicate synergism, additive effect, and antagonism, respectively. Based on these algorithms, computer software has been developed to allow automated simulation of synergism and antagonism at all dose or effect levels. It displays the dose-effect curve, median-effect plot, combination index plot, isobologram, dose-reduction index plot, and polygonogram for in vitro or in vivo studies. This theoretical development, experimental design, and computerized data analysis have facilitated dose-effect analysis for single drug evaluation or carcinogen and radiation risk assessment, as well as for drug or other entity combinations in a vast field of disciplines of biomedical sciences. In this review, selected examples of applications are given, and step-by-step examples of experimental designs and real data analysis are also illustrated. The merging of the mass-action law principle with mathematical induction-deduction has been proven to be a unique and effective scientific method for general theory development. The median-effect principle and its mass-action law based computer software are gaining increased applications in biomedical sciences, from how to effectively evaluate a single compound or entity to how to beneficially use multiple drugs or modalities in combination therapies.
Measuring colorfulness in natural images

We want to integrate colourfulness in an image quality evaluation framework. This quality framework is meant to evaluate the perceptual impact of a compression algorithm or an error prone communication channel on the quality of an image. The image might go through various enhancement or compression algorithms, resulting in a different -- but not necessarily worse -- image. In other words, we will measure quality but not fidelity to the original picture. While modern colour appearance models are able to predict the perception of colourfulness of simple patches on uniform backgrounds, there is no agreement on how to measure the overall colourfulness of a picture of a natural scene. We try to quantify the colourfulness in natural images to perceptually qualify the effect that processing or coding has on colour. We set up a psychophysical category scaling experiment, and ask people to rate images using 7 categories of colourfulness. We then fit a metric to the results, and obtain a correlation of over 90% with the experimental data. The metric is meant to be used real time on video streams. We ignored any issues related to hue in this paper.
Growth, technological interdependence and spatial externalities: theory and evidence

This paper presents a theoretical growth model which explicitly takes into account technological interdependence among economies and examines the impact of spillover effects. Technological interdependence is assumed to operate through spatial externalities. The magnitude of the physical capital externalities at steady state, which is not usually identified in the literature, is estimated using a spatial econometric specification. Spatial externalities are found to be significant. This spatially augmented Solow model yields a conditional convergence equation which is characterized by parameter heterogeneity. A locally linear spatial autoregressive specification is then estimated providing a convergence speed estimate for each country of the sample. Copyright © 2007 John Wiley & Sons, Ltd.
Genetic Steps to Organ Laterality in Zebrafish

All internal organs are asymmetric along the left–right axis. Here we report a genetic screen to discover mutations which perturb organ laterality. Our particular focus is upon whether, and how, organs are linked to each other as they achieve their laterally asymmetric positions. We generated mutations by ENU mutagenesis and examined F3 progeny using a cocktail of probes that reveal early primordia of heart, gut, liver and pancreas. From the 750 genomes examined, we isolated seven recessive mutations which affect the earliest left–right positioning of one or all of the organs. None of these mutations caused discernable defects elsewhere in the embryo at the stages examined. This is in contrast to those mutations we reported previously (Chen et al., 1997) which, along with left–right abnormalities, cause marked perturbation in gastrulation, body form or midline structures. We find that the mutations can be classified on the basis of whether they perturb relationships among organ laterality. In Class 1 mutations, none of the organs manifest any left–right asymmetry. The heart does not jog to the left and normally leftpredominant BMP4 in the early heart tube remains symmetric. The gut tends to remain midline. There frequently is a remarkable bilateral duplication of liver and pancreas. Embryos with Class 2 mutations have organotypic asymmetry but, in any given embryo, organ positions can be normal, reversed or randomized. Class 3 reveals a hitherto unsuspected gene that selectively affects laterality of heart. We find that visceral organ positions are predicted by the direction of the preceding cardiac jog. We interpret this as suggesting that normally there is linkage between cardiac and visceral organ laterality. Class 1 mutations, we suggest, effectively remove the global laterality signals, with the consequence that organ positions are effectively symmetrical. Embryos with Class 2 mutations do manifest linkage among organs, but it may be reversed, suggesting that the global signals may be present but incorrectly orientated in some of the embryos. That laterality decisions of organs may be independently perturbed, as in the Class 3 mutation, indicates that there are distinctive pathways for reception and organotypic interpretation of the global signals.
On the low-rank approach for semidefinite programs arising in synchronization and community detection

To address difficult optimization problems, convex relaxations based on semidefinite programming are now common place in many fields. Although solvable in polynomial time, large semidefinite programs tend to be computationally challenging. Over a decade ago, exploiting the fact that in many applications of interest the desired solutions are low rank, Burer and Monteiro proposed a heuristic to solve such semidefinite programs by restricting the search space to low-rank matrices. The accompanying theory does not explain the extent of the empirical success. We focus on Synchronization and Community Detection problems and provide theoretical guarantees shedding light on the remarkable efficiency of this heuristic.
Mixing of Two Miscible Liquids in T-shaped Microdevices

Numerical simulations were performed to study the flow fields and mixing characteristics of liquid flows converging in a T-shaped micromixer, when the two inlet fluids are both water or water and ethanol. We showed that at smaller Reynolds number, Re < 100, mixing is controlled by transverse diffusion, and therefore by the residence times of each fluids. Accordingly, mixing ethanol and water is slightly easier than mixing water with water, due to the fact that, as ethanol is slightly more viscous than water and therefore it is slower, the residence time of water-ethanol mixtures is larger than that of the water-water case. On the other hand, at larger Reynolds number, mixing water and ethanol may take considerably longer, as the onset of engulfment is retarded and occurs at larger Reynolds number, namely increasing from Re ≅ 140 in the water-water case to Re ≅ 230 in the water-ethanol case. This is due to the fact that a water-ethanol mixture has a viscosity that is up to almost three times larger than that of water; therefore, at the confluence of the T-mixer, the water and the ethanol streams are separated by a quite viscous layer of a water-ethanol mixture, that hampers any vortex formation, thus retarding mixing.
Uncoupling of disease activity and structural damage. Does it matter clinically?

Rheumatoid arthritis (RA) is an autoimmune disease characterised by synovial inflammation that can lead to joint damage through bone and cartilage destruction, loss of function and decreased quality of life. Fortunately, over the past few years, we have witnessed major advances in the management of RA with new agents and treatment strategies that have improved outcomes and made remission become a realistic goal. True remission has been defined as a state where there is no evidence of disease activity with complete resolution of signs and symptoms as well as arrest of joint damage and disability progression. Hence, inhibition of radiographic progression has become a major therapeutic goal given its direct relationship to patient function and quality of life.1 Clinical remission can be achieved with disease-modifying antirheumatic drugs (DMARD) alone or may need a combination of DMARDs and biologic agents. Radiographic remission is more complex as we have learned from the probability plots that the mean/median change of radiographic progression is accounted for by a minority of patients who progress radiographically. Indeed, regardless of the therapy used, approximately 50% of patients will not show radiographic progression over 2–3 years; This percentage increases up to 75–85% of patients receiving combination therapy, and those who do progress, progress less than patients on methotrexate alone.2 It has long been thought that prevention of radiographic progression was achieved through the eradication of synovial inflammation, and that antitumour necrosis factor (TNF) agents were more effective at reducing structural progression through a better control of inflammation. However, recent posthoc …
Community-Based Appraisal of the Effects of Parenteral Nutrition Versus Enteral Nutrition on the Quality of Care for Patients With Acute Pancreatitis

Background Enteral nutrition (EN) rather than parenteral nutrition (PN) has been advocated in treatment guidelines for acute pancreatitis (AP) as endorsed in randomized studies or meta-analyses. The findings derived from those studies would recognize the criticism of smaller sample sizes or limited patient case-mixes. To determine the generalizability of those findings, community-based appraisal on the advantages of EN over PN is required. Using a Japanese administrative database between 2006 and 2010, we determine whether EN is superior to PN in the real clinical settings. Methods A total of 24,913 patients diagnosed with AP at admission in 1,000 hospitals were identified. Among them, we analyzed 1,803 patients of ≥ 15 years who received EN or PN for AP across 480 hospitals. Among three nutrition categories of PN only, EN only and PN with EN, we examined patient characteristics, comorbidities, complications, AP severity score determined by the Ministry of Health, Labor and Welfare, surgical procedures for the biliary/pancreatic system, use of artificially assisted ventilation and hemodialysis proxy of multiple organ failures and hospital teaching status. To identify the variables associated with PN use, a logistic regression model was used and the propensity score (PS) was calculated to control for the selection bias of patient case-mix preferring PN use. Then, we compared mortality, length of hospital stay (LOS), total charges (TC) and commencement day of oral food intake between EN and PN. Results A total of 1,191 PN patients, 330 EN patients and 282 mixed EN and PN patients were identified. EN was indicated for patients with mild AP and procedures for the pancreas. PS matching analysis indicated that PN had a higher mortality compared with EN, and PN significantly increased LOS and TC compared with EN. PN deterred the commencement of oral food intake. Conclusions Community-based study has shown that EN was employed in the less severe case-mixed. Even though considering that selection bias, EN was still superior to PN in AP. Physicians should be aware of the guidelines for the advocacy of EN and need to carefully consider the indications for EN to optimize the quality of AP care.