Miracle-dz/UniFAR-FTUs huggingface dataset:
A Biopsychosocial Process Model of Health and Complaints in Children and Adolescents

The purpose of the study was to test a biopsychosocial process model based on theoretically and empirically supported factors previously found to influence health and complaints in children and adolescents. Participants (N = 823) of the ages of nine, 14 or 18 were administered parts of the Health Behaviour in School-Aged Children Questionnaire and a physical activity questionnaire. They subsequently underwent physical fitness tests and a medical examination. For complaints, direct and indirect influences over four levels (socioeconomic status, physical activity of relatives and peers, physical activity and physical fitness) were shown, but the findings did not hold for health. The interpretation of expected and unexpected results is discussed.
The Trehalose 6-Phosphate/SnRK1 Signaling Pathway Primes Growth Recovery following Relief of Sink Limitation1[W][OA]

The T6P/SnRK1 mechanism of growth regulation responds to sink growth restriction and recovery following low-temperature limitation. Trehalose 6-P (T6P) is a sugar signal in plants that inhibits SNF1-related protein kinase, SnRK1, thereby altering gene expression and promoting growth processes. This provides a model for the regulation of growth by sugar. However, it is not known how this model operates under sink-limited conditions when tissue sugar content is uncoupled from growth. To test the physiological importance of this model, T6P, SnRK1 activities, sugars, gene expression, and growth were measured in Arabidopsis (Arabidopsis thaliana) seedlings after transfer to cold or zero nitrogen compared with sugar feeding under optimal conditions. Maximum in vitro activities of SnRK1 changed little, but T6P accumulated up to 55-fold, correlating with tissue Suc content in all treatments. SnRK1-induced and -repressed marker gene expression strongly related to T6P above and below a threshold of 0.3 to 0.5 nmol T6P g−1 fresh weight close to the dissociation constant (4 µm) of the T6P/ SnRK1 complex. This occurred irrespective of the growth response to Suc. This implies that T6P is not a growth signal per se, but through SnRK1, T6P primes gene expression for growth in response to Suc accumulation under sink-limited conditions. To test this hypothesis, plants with genetically decreased T6P content and SnRK1 overexpression were transferred from cold to warm to analyze the role of T6P/SnRK1 in relief of growth restriction. Compared with the wild type, these plants were impaired in immediate growth recovery. It is concluded that the T6P/SnRK1 signaling pathway responds to Suc induced by sink restriction that enables growth recovery following relief of limitations such as low temperature.
Voltammetric Determination of Anethole on La2O3/CPE and BDDE

In this work, DPV determination of anethole was presented using various carbon, two-diameter (1.5 and 3 mm) electrodes, that is, BDD, GC, CP, and CP doped by La2O3 and CeO2 nanoparticles. La2O3/CPE to our best knowledge was proposed first time. Cyclic voltammograms confirmed totally irreversible electrode electrooxidation process, controlled by diffusion, in which two electrons take part. The most satisfactory sensitivity 0.885 ± 0.016 µA/mg L−1 in 0.1 mol L−1 acetate buffer was obtained for La2O3/CPE with the correlation coefficient r of 0.9993, while for BDDE it was 0.135 ± 0.003 µA/mg L−1 with r of 0.9990. The lowest detection limit of 0.004 mg L−1 was reached on La2O3/CPE (3 mm), what may be compared with the most sensitive conjugate methods, but in the proposed approach, no sample preparation and analyte separation was needed. Anethole was successfully determined in specially prepared ethanol extracts of herbal mixtures of various compositions, which imitated real products. The proposed procedure was verified in analysis of commercial products, that is, anise essential oil, which contains a large concentration of anethole, and in alcohol drinks like Metaxa, Ouzo, and Rakija, in which the considered analyte occurs on trace levels. Structure and properties of the considered nanopowders and graphite pastes were investigated by EDX, SEM, and EIS.
Sexually size dimorphic brains and song complexity in passerine birds

Neural correlates of bird song involve the volume of particular song nuclei in the brain that govern song development, production, and perception. Intra- and interspecific variation in the volume of these song nuclei are associated with overall brain size, suggesting that the integration of complex songs into the brain requires general neural augmentation. In a comparative study of passerine birds based on generalized least square models, we tested this hypothesis by exploring the interspecific relationship between overall brain size and repertoire size. We found no significant association between song complexity of males and brain size adjusted for body size. However, species in which males produced complex songs tended to have sex differences in overall brain size. This pattern became stronger when we controlled statistically for female song complexity by using sex differences in song complexity. In species with large differences in song complexity, females evolved smaller brains than did males. Our results suggest no role for the evolution of extended neural space, as reflected by total brain size, owing to song complexity. However, factors associated with sexual selection mirrored by sex differences in song complexity were related to sexual dimorphism in overall brain size. Copyright 2005.
A comparative analysis of pollen limitation in flowering plants

We conducted a comparative analysis to determine life history and ecological correlates of pollen limitation among 224 species of animal-pollinated flowering plants. To test predictions concerning the occurrence of pollen limitation, species were classified categorically for six life-history traits (self-compatible vs. self-incompatible, autogamous vs. non-autogamous, specialized vs. unspecialized floral morphology, nectariferous vs. nectarless, monocarpic vs. polycarpic, herbaceous vs. woody) and two ecological conditions (presence in open vs. forested habitats and temperate vs. tropical biomes). Pollen limitation of species in contrasting categories was compared using non-parametric tests (TIPs analysis) and phylogenetically-independent contrasts (PICs). The results of TIPs and PICs analyses were generally congruent, although fewer significant contrasts were evident with PICs, probably because of low statistical power. Overall the results suggest that the influence of phylogenetic history on the intensity of pollen limitation was not particularly strong. Nonetheless, significant variation in the degree of pollen limitation was demonstrated among seven angiosperm families suggesting some phylogenetic component to the phenomenon. With both TIPs and PICs, pollen limitation was less intense in self-compatible and autogamous species. TIPs analysis demonstrated that herbaceous, nectariferous, and temperate species were less likely to be pollen-limited, but using PICs this could only be corroborated for those that were self-incompatible. None of the traits were singularly unambiguous predictors of pollen limitation, possibly reflecting the stochastic nature of pollinator service.
Nonexistence of Positive Supersolutions of Elliptic Equations via the Maximum Principle

We introduce a new method for proving the nonexistence of positive supersolutions of elliptic inequalities in unbounded domains of ℝ n . The simplicity and robustness of our maximum principle-based argument provides for its applicability to many elliptic inequalities and systems, including quasilinear operators such as the p-Laplacian, and nondivergence form fully nonlinear operators such as Bellman-Isaacs operators. Our method gives new and optimal results in terms of the nonlinear functions appearing in the inequalities, and applies to inequalities holding in the whole space as well as exterior domains and cone-like domains.
Conserved role for autophagy in Rho1-mediated cortical remodeling and blood cell recruitment

Dynamic regulation of cell shape underlies many developmental and immune functions. Cortical remodeling is achieved under the central control of Rho GTPase pathways that modulate an exquisite balance in the dynamic assembly and disassembly of the cytoskeleton and focal adhesions. Macroautophagy (autophagy), associated with bulk cytoplasmic remodeling through lysosomal degradation, has clearly defined roles in cell survival and death. Moreover, it is becoming apparent that proteins, organelles, and pathogens can be targeted for autophagic clearance by selective mechanisms, although the extent and roles of such degradation are unclear. Here we report a conserved role for autophagy specifically in the cortical remodeling of Drosophila blood cells (hemocytes) and mouse macrophages. Continuous autophagy was required for integrin-mediated hemocyte spreading and Rho1-induced cell protrusions. Consequently, hemocytes disrupted for autophagy were impaired in their recruitment to epidermal wounds. Cell spreading required ref(2)P, the Drosophila p62 multiadaptor, implicating selective autophagy as a novel mechanism for modulating cortical dynamics. These results illuminate a specific and conserved role for autophagy as a regulatory mechanism for cortical remodeling, with implications for immune cell function.
Foundations of invasion genetics: the Baker and Stebbins legacy

Invasion genetics is a relatively new discipline that investigates patterns of genetic variation in populations of invasive species and their ecological and evolutionary consequences. Evolutionary biologists have a long‐standing interest in colonizing species, owing to their short life cycles and widespread distributions, but not until publication of The Genetics of Colonizing Species (1965), edited by H.G. Baker and G.L. Stebbins, was a synthesis on the genetics and evolution of colonizers available. Here, I make the case that the Baker and Stebbins volume is the foundational document for invasion genetics, and in conjunction with the increased use of genetic markers and development of invasion biology, resulted in the birth of this new field over the past two decades. I consider the historical origins and legacy of the Baker and Stebbins volume and review some of the key issues that were addressed. I provide biographical sketches of the two editors, emphasizing their contrasting backgrounds and personalities. I review examples from my own work on plant invasions that are relevant to issues discussed by contributors to the volume. These include the following: determinants of invasion success, life history trade‐offs, generalist vs. specialist strategies, general‐purpose genotypes, adaptive phenotypic plasticity, mating systems and the influence of bottlenecks on genetic variation. I conclude by posing several key questions in invasion genetics and argue that one of the main challenges that the area faces is to integrate experimental field studies of the ecology and demography of populations with the largely descriptive approaches that have tended to dominate most research to date.
Pulsing of Membrane Potential in Individual Mitochondria: A Stress-Induced Mechanism to Regulate Respiratory Bioenergetics in Arabidopsis[W]

This work examines membrane polarization in mitochondria, finding that mitochondria in living Arabidopsis root cells undergo sporadic rapid cycles of partial dissipation and restoration of membrane potential. These pulses are induced in tissues challenged by high temperature, H2O2, or cadmium, cause alkalinization of the matrix, and likely result from calcium influx. Mitochondrial ATP synthesis is driven by a membrane potential across the inner mitochondrial membrane; this potential is generated by the proton-pumping electron transport chain. A balance between proton pumping and dissipation of the proton gradient by ATP-synthase is critical to avoid formation of excessive reactive oxygen species due to overreduction of the electron transport chain. Here, we report a mechanism that regulates bioenergetic balance in individual mitochondria: a transient partial depolarization of the inner membrane. Single mitochondria in living Arabidopsis thaliana root cells undergo sporadic rapid cycles of partial dissipation and restoration of membrane potential, as observed by real-time monitoring of the fluorescence of the lipophilic cationic dye tetramethyl rhodamine methyl ester. Pulsing is induced in tissues challenged by high temperature, H2O2, or cadmium. Pulses were coincident with a pronounced transient alkalinization of the matrix and are therefore not caused by uncoupling protein or by the opening of a nonspecific channel, which would lead to matrix acidification. Instead, a pulse is the result of Ca2+ influx, which was observed coincident with pulsing; moreover, inhibitors of calcium transport reduced pulsing. We propose a role for pulsing as a transient uncoupling mechanism to counteract mitochondrial dysfunction and reactive oxygen species production.
The 2016 HIV diagnosis and care cascade in New South Wales, Australia: meeting the UNAIDS 90‐90‐90 targets

The HIV Strategy in New South Wales (NSW) Australia aims to virtually eliminate HIV transmission by 2020. We estimated the 2016 HIV diagnosis and care cascade for the state of NSW, with a focus on introducing population‐based data to improve data quality and assess progress towards the UNAIDS 90‐90‐90 targets.
Experimental insights on Darwin's cross-promotion hypothesis in tristylous purple loosestrife (Lythrum salicaria).

PREMISE OF THE STUDY Darwin proposed that the reciprocal arrangement of anthers and stigmas in heterostylous plants promotes cross-pollination through pollen segregation on pollinators' bodies. The floral tube in most heterostylous species constrains the feeding posture of pollinators determining the site of contact with sex organs located at different heights within a flower. Here, we evaluate Darwin's hypothesis in tristylous Lythrum salicaria, a species with a partially tubular corolla, and examine the extent to which the location of sex organs within a flower influence compatible and incompatible pollination. We predicted that the proficiency of cross-pollination would increase for more inserted sex organs due to the restrictions imposed by the floral tube on pollinator positioning. METHODS We used experimental trimorphic and monomorphic arrays and emasculated flowers to quantify intermorph pollen transfer and capture among all sex-organ heights, and estimated the contribution of intraflower self-pollination, geitonogamous self-pollination, and intramorph outcross pollination to total intramorph pollination. KEY RESULTS As predicted, disassortative pollination varied significantly with sex-organ height and was highest for short-level organs and lowest for long-level organs. In monomorphic arrays, most intramorph pollination resulted from outcross pollination followed by intraflower and geitonogamous self-pollination. CONCLUSIONS Our results provide evidence for the Darwinian hypothesis. Reciprocal herkogamy promoted varying degrees of disassortative pollination with the magnitude strongly influenced by sex-organ height within a flower.
Prevalence of IDH1/2 Mutations in Different Subtypes of Glioma in the North-East Population of Morocco.

BACKGROUND Genetic alterations in gliomas have increasing importance for classification purposes. Thus, we are especially interested in studying IDH mutations which may feature potential roles in diagnosis, prognosis and response to treatment. Our aim was to investigate IDH mutations in diffuse glioma patients diagnosed in university hospital centre of Fez in Morocco. MATERIALS AND METHODS IDH1 codon 132 and IDH2 codon 172 were direct-sequenced in 117 diffuse glioma samples diagnosed and treated in University Hospital Hassan II between 2010 and 2014. RESULTS The R132H IDH1 mutation was identified in 43/117 tumor samples and R172K IDH2 mutation was detected in only one anaplastic oligodendroglioma. IDH mutations were observed in 63.2% of astrocytomas, 73.3% of diffuse oligodendrogliomas and 12.90% of glioblastomas. CONCLUSIONS Our results confirmed other studies published earlier for other populations with some small discrepancies.
Risk of myocardial infarction with use of selected non-steroidal anti-inflammatory drugs in patients with spondyloarthritis and osteoarthritis

Objectives Spondyloarthritis (SpA) is associated with an increased risk of myocardial infarction (MI) due to underlying inflammation and possibly due to medications such as certain non-steroidal anti-inflammatory drugs (NSAIDs). We sought to describe MI risk among patients with SpA who were prescribed NSAIDs, and to compare the pattern of risk in SpA with that in osteoarthritis (OA). Methods Nested case-control studies were performed using The Health Improvement Network (THIN). Underlying cohorts included adults with incident SpA or OA who had >1 NSAID prescription and no history of MI. Within each cohort, we matched each MI case to four controls without MI. NSAID use was categorised as: (a) current (prescription date 0–180 days prior to index date), (b) recent (181–365 days) or (c) remote (>365 days). We performed conditional logistic regression to compare the odds of current or recent NSAID use relative to remote use of any NSAID, considering diclofenac and naproxen specifically. Results Within the SpA cohort of 8140 and the OA cohort of 244 339, there were 115 and 6287 MI cases, respectively. After adjustment, current diclofenac use in SpA was associated with an OR of 3.32 (95% CI 1.57 to 7.03) for MI. Naproxen was not associated with any increase (adjusted OR 1.19, 95% CI 0.53 to 2.68). A ratio of ORs for SpA/diclofenac relative to OA/diclofenac was 2.64 (95% CI 1.24 to 5.58). Conclusions MI risk in SpA is increased among current users of diclofenac, but not naproxen. The MI risk with diclofenac in SpA appears to differ from that in OA.
Mediators of Behavior Change Maintenance in Physical Activity Interventions for Young and Middle-Aged Adults: A Systematic Review.

Background Regular physical activity is important for maintaining physical and mental health. Benefits are optimized when physical activity is maintained. Understanding causal mechanisms is important to inform future interventions. Purpose To investigate mediators of physical activity maintenance. Methods Six databases were searched (Medline, EMBASE, PsycINFO, CINAHL, Cochrane Database of Systematic Reviews, and Web of Science). Eligibility criteria included adult nonclinical populations, validated measure of physical activity behavior at baseline and at least 6 months postbaseline, control/comparison group(s), and reported mediators of physical activity behavior change. Mediators were examined according to (i) formal mediation tests, (ii) mediator association with physical activity outcome, and (iii) intervention effects on mediators. Results There were few formal mediation tests conducted (n = 12/39 included studies), and various other methodological limitations were identified. There was some evidence that effective mediators in formal mediation tests at 6 months and later included the "behavioral processes of change" (n = 5/6). Many of the included interventions were not effective for changing targeted mediators (only 34% of 413 tests of mediator changes were significant). Conclusions There were a number of methodological and statistical limitations in the evidence base. In future, prespecified formal mediation tests should be carried out and could be aided by a formal framework. Social and environmental variables should be considered in addition to intrapersonal variables. Improving knowledge of how to change hypothesized mediators, based on theory and evidence, will reveal how physical activity behavior change maintenance can be achieved. Maintenance research would be enhanced by establishing a formal definition of behavior change "maintenance. " PROSPERO registration: PROSPERO 2015:CRD- 42015025462.
Effet des modifications de surface sur les propriétés morphologiques, mécaniques et rhéologiques de composites à base de fibres biosourcées et de polyéthylène

iv Table des matières . vii Liste des Tableaux . xiv Liste des Figures . xvi Nomenclature. xix Abréviations . xix Symboles . xx Remerciements . xxii Avant-propos . xxiv Chapitre
PROBLEMS AND PROSPECTS OF COTTON IN DIFFERENT ZONES OF INDIA

Cotton cultivation needs to be sustainable, offering livelihood security to millions of marginal and small farmers; such an enterprise has to be knowledge-based and market–driven and needs to evolve continuously through innovations in frontier sciences to break yield and quality barriers for satisfying present and future national needs and attaining global competitiveness with larger spin–off benefits to India. Cotton is the most important commercial crop contributing nearly 75% of total raw material needs of textile industry in our country. Cotton and Textile exports account for good share of foreign Exchange earnings of India, crossing Rs.70,000 crores. India has achieved significant breakthrough in cotton yarn exports besides increasing its global market share in cotton textiles and apparels. About 60 million people of our country are involved directly or indirectly in cotton production, processing, textiles and related activities.
Evaluation of Anti-Cancer Potential of Capsaicin-Loaded TrimethylChitosan-Based Nanoparticles in HepG2 Hepatocarcinoma Cells

Hepatocellular carcinoma (HCC) is a highly aggressive malignancy characterized by its high resistance to chemotherapeutic agents leading to high morbidity and mortality rates. Capsaicin, the active ingredient of hot peppers, has been reported for its potential as an active anti-cancer agent. In this study, we hypothesized that incorporating capsaicin into nanocarriers might improve its pharmacokinetics. As a result, densely dispersed capsaicin-loaded trimethyl-chitosan nanoparticles (CL-NPs) were developed and their anti-tumor effect was investigated in comparison with capsaicin on human HepG2 cells. The CL-NPs were obtained via iontropic gelation of cationic trimethyl chitosan (TMCS). Both synthesized TMCS and TMCS-based nanoparticles were characterized using zeta analyzer, nanosizer, and TEM. Human hepatoma cell line (HepG2) were cultured then divided into 4 groups receiving ethanol, conventional capsaicin, plain nanoparticles (PNs), or CL-NPs in dose of 100 μM. The apoptotic activity in the cell line was evaluated by DNA fragmentation assay, immunocytochemistry for caspase-3 and BCL-2, in addition to gene expression studies of BCL-2, and Bax genes via RT-PCR. The capsaicin effect on HCC response to chemotherapy was also assessed by studying the level of MDR-1 (multidrug resistance) gene expression. CL-NPs in dose of 100 μM, 24 h after treatment, showed more upregulation of Bax and downregulation of both BCL-2 and MDR-1 genes in comparison with conventional capsaicin. In addition, immunocytochemistry assay revealed that both capsaicin and plain NPs show higher expression of caspase-3 and lower expression of BCL-2 than the control group, while the group treated with CL-NPs showed complete necrosis. This indicates that plain TMCS nanoparticles had a little anti-apoptotic effect by themselves. Our findings highlight the potential of the developed CL-NPs as an effective anti-cancer agent which efficiently induced apoptosis in human HepG2 hepatocarcinoma cells. Moreover, a possible role in improving response to chemotherapy has been observed through downregulation of MDR-1 gene.