Miracle-dz/UniFAR-FTUs huggingface dataset:
Gravitational radiation from gamma-ray bursts as observational opportunities for LIGO and VIRGO

Gamma-ray bursts are believed to originate in core-collapse of massive stars. This produces an active nucleus containing a rapidly rotating Kerr black hole surrounded by a uniformly magnetized torus represented by two counter-oriented current rings. We quantify black hole spin-interactions with the torus and charged particles along open magnetic flux-tubes subtended by the event horizon. A major output of Egw=4e53 erg is radiated in gravitational waves of frequency fgw=500 Hz by a quadrupole mass-moment in the torus. Consistent with GRB-SNe, we find (i) Ts=90s (tens of s, Kouveliotou et al. 1993), (ii) aspherical SNe of kinetic energy Esn=2e51 erg (2e51 erg in SN1998bw, Hoeflich et al. 1999) and (iii) GRB-energies Egamma=2e50 erg (3e50erg in Frail et al. 2001). GRB-SNe occur perhaps about once a year within D=100Mpc. Correlating LIGO/Virgo detectors enables searches for nearby events and their spectral closure density 6e-9 around 250Hz in the stochastic background radiation in gravitational waves. At current sensitivity, LIGO-Hanford may place an upper bound around 150MSolar in GRB030329. Detection of Egw thus provides a method for identifying Kerr black holes by calorimetry.
Why Humans Cooperate: A Cultural and Evolutionary Explanation

Cooperation among humans is one of the keys to our great evolutionary success. Natalie and Joseph Henrich examine this phenomena with a unique fusion of theoretical work on the evolution of cooperation, ethnographic descriptions of social behavior, and a range of other experimental results. Their experimental and ethnographic data come from a small, insular group of middle-class Iraqi Christians called Chaldeans, living in metro Detroit, whom the Henrichs use as an example to show how kinship relations, ethnicity, and culturally transmitted traditions provide the key to explaining the evolution of cooperation over multiple generations.
A Control System for Rotary Blood Pumps Based on Suction Detection

A control system for rotary ventricular assist devices was developed to automatically regulate the pumping speed of the device to avoid ventricular suction. The control system comprises a suction detector and a fuzzy logic controller (FLC). The suction detector can correctly classify pump flow patterns, using a discriminant analysis (DA) model that combines several indices derived from the pump flow signal, to classify the pump status as one of the following: no suction (NS), moderate suction (MS), and severe suction (SS). The discriminant scores, which are the output of the suction detector, were used as inputs to the FLC. Based on this information, the controller updates pump speed, providing adequate flow and pressure perfusion to the patient. The performance of the control system was tested in simulations over a wide range of physiological conditions, including hypertension, exercise, and strenuous exercising for healthy, sick, and very sick hearts, using a lumped parameter model of the circulatory system coupled with a left ventricular assist device. The controller was able to maintain cardiac output and mean arterial pressure within acceptable physiologic ranges, while avoiding suction, demonstrating the feasibility of the proposed control system.
Schedulability analysis for tasks with static and dynamic offsets

In this paper we present an extension to current schedulability analysis techniques for periodic task with offsets, scheduled under a preemptive fixed priority scheduler. Previous techniques allowed only static offsets restricted to being smaller than the task periods. With the extension presented in this paper, we eliminate this restriction and we allow both static and dynamic offsets. The most significant application of this extension is in the analysis of multiprocessor and distributed systems. We show that we can achieve a significant increase of the maximum schedulable utilization by using the new technique, as opposed to using previously known worst-case analysis techniques for distributed systems.
Collagen Membrane Resorption in Dogs: A Comparative Study

Guided tissue barriers using materials such as collagen are used in the hope of excluding epithelium and the gingival corium from the root surface or alveolar bone to facilitate regeneration. Convention suggests that the longer a membrane remains intact, the better the regeneration results. The purpose of this study was to determine the resorption rates of various collagen membranes in the oral cavity of dogs. Twelve adult mongrel dogs had three different collagen membranes (BioGide, AlloDerm porcine-derived, and AlloDerm human-derived) randomly inserted and secured into surgical pouches made in their palates. Full-thickness tissue punch biopsy specimens taken at 1, 2, 3, or 4 months after surgery were evaluated histologically for membrane intactness and other associated changes. At 1 month, all membranes had slight to moderate degradation. At 2 months, all membranes had moderate to severe degradation with the exception of one AlloDerm human-derived membrane that was intact. At 3 months, all membranes had severe degradation to not identifiable. At 4 months, all membranes had severe degradation to completely absent. Blood vessel penetration varied from none to moderate. Inflammation was found in only two samples. In the dog, all three tested collagen membranes showed slight to moderate degradation at 1 month and were severely degraded to completely absent at 4 months. Within the limits of transferring animal data to humans, clinicians need to be aware of these resorption rates when selecting membranes for guided tissue and bone regeneration.
Long-Term Maternal Hypoxia

Antenatal maternal long-term hypoxia (LTH) can alter serotonin (5-HT) and calcium (Ca2+) signaling in fetal pulmonary arteries (PAs) and is associated with persistent pulmonary hypertension of the newborn (PPHN). In humans, the antenatal maternal hypoxia can be secondary to smoking, anemia, and chronic obstructive pulmonary disorders. However, the mechanisms of antenatal maternal hypoxia-related PPHN are unresolved. Because both LTH and 5-HT are associated with PPHN, we tested the hypothesis that antenatal maternal LTH can increase 5-HT-mediated PA contraction and associated extracellular Ca2+ influx through L-type Ca2+ channels (CaL), nonselective cation channels (NSCCs), and reverse-mode sodium–calcium exchanger (NCX) in the near-term fetus. We performed wire myography and confocal-Ca2+ imaging approaches on fetal lamb PA (∼140 days of gestation) from normoxic ewes or those acclimatized to high-altitude LTH (3801 m) for ∼110 days. Long-term hypoxia reduced the potency but not the efficacy of 5-HT-induced PA contraction. Ketanserin (100 nmol/L), a 5-HT2A antagonist, shifted 5-HT potency irrespective of LTH, while GR-55562 (1 µmol/L), a 5-HT1B/D inhibitor, antagonized 5-HT-induced contraction in normoxic fetuses only. Various inhibitors for CaL, NSCC, and reverse-mode NCX were used in contraction studies. Contraction was reliant on extracellular Ca2+ regardless of maternal hypoxia, NSCC was more important to contraction than CaL, and reverse-mode NCX had little or no role in contraction. Long-term hypoxia also attenuated the effects of 2-APB and flufenamic acid and reduced Ca2+ responses observed by imaging studies. Overall, LTH reduced 5HT1B/D function and increased NSCC-related Ca2+-dependent contraction in ovine fetuses, which may compromise pulmonary vascular function in the newborn.
Anthropometrics, body shape over 12 years and risk of cancer events in pre‐ and post‐menopausal women

Studies of anthropometry and cancer have focused on body mass index (BMI). Relations between weight, waist (WC) and hip circumferences (HC), birth length and adult height with cancer are less well studied. Women from the French E3N study, born between 1925 and 1950, were followed biennially from 1995 until 2008. Body shape was classed into four groups based on median WC and HC at baseline. Hazard ratios (HRs) were estimated by Cox proportional hazards regression models. Over the 12 years of follow‐up, 7,247 of 63,798 women developed cancer. As WC increased, we found a trend for decreasing cancer risk in pre‐menopausal women, which reversed to an increasing risk in post‐menopausal women. This remained unchanged after further adjustment for HC /or height [HR: 0.72 (0.52–1.00) before menopause and 1.17 (1.04–1.31) in the 5th vs. 1st quintile of HC], and were similar after exclusion of breast cancer. We showed that large body shape decreased cancer risk before menopause and increased it after [HR: 0.87 (0.73–1.02) and 1.11 (1.04–1.17), respectively, in women with large waist and hips compared to small waist and hips]. Adult height was associated with an non‐significant increase in cancer in pre‐menopause and a significant cancer risk in menopause, independent of other anthropometric characteristics [5th vs. 1st quintile [HR: 1.24 (0.98–1.56) and 1.20 (1.10–1.30)], respectively as was long birth length in post‐menopausal women [HR: 1.18 (1.07–1.30) compared to medium birth length]. These results suggest independent roles of height and WC on cancer risk, through different pathways.
Statistical Properties of the Wavelet Variance Estimator for Non-gaussian/non-linear Time Series

{ The wavelet variance decomposes the variance of a time series into components associated with diierent scales, and is widely used in scientiic and engineering studies. We consider an estimator of the wavelet variance based on the maximal-overlap (or stationary, or undecimated) discrete wavelet transform. The asymptotic distribution of this wavelet variance estimator is derived for a wide class of stochastic processes, not necessarily Gaussian or linear. We show how to estimate the variance of this distribution using spectral methods. Simulations connrm the theoretical results. At small scales, estimates of the variance of the wavelet variance estimate for the surface albedo of pack ice, a strongly non-Gaussian series, are much larger than those obtained under a Gaussian assumption.
Semantic Processing in the Left Inferior Prefrontal Cortex: A Combined Functional Magnetic Resonance Imaging and Transcranial Magnetic Stimulation Study

The involvement of the left inferior prefrontal cortex (LIPC) in phonological processing is well established from both lesion-deficit studies with neurological patients and functional neuroimaging studies of normals. Its involvement in semantic processing, on the other hand, is less clear. Although many imaging studies have demonstrated LIPC activation during semantic tasks, this may be due to implicit phonological processing. This article presents two experiments investigating semantic functions in the LIPC. Results from a functional magnetic resonance imaging experiment demonstrated that both semantic and phonological processing activated a common set of areas within this region. In addition, there was a reliable increase in activation for semantic relative to phonological decisions in the anterior LIPC while the opposite comparison (phonological vs. semantic decisions) revealed an area of enhanced activation within the posterior LIPC. A second experiment used transcranial magnetic stimulation (TMS) to temporarily interfere with neural information processing in the anterior portion of the LIPC to determine whether this region was essential for normal semantic performance. Both repetitive and single pulse TMS significantly slowed subjects' reactions for the semantic but not for the perceptual control task. Our results clarify the functional anatomy of the LIPC by demonstrating that anterior and posterior regions contribute to both semantic and phonological processing, albeit to different extents. In addition, the findings go beyond simply establishing a correlation between semantic processing and activation in the LIPC and demonstrate that a transient disruption of processing selectively interfered with semantic processing.
Impact of peanut allergy on quality of life, stress and anxiety in the family

Background: Peanut allergy (PA) is known to impact on quality of life (QoL) of the sufferer, but little research has focused on all family members. We therefore sought to establish the impact of PA on QoL and reported anxiety of children with clinically confirmed PA, their parents and older siblings.
Use of 99mTc-mononuclear leukocyte scintigraphy in nosocomial fever

Purpose: To determine the overall diagnostic accuracy of mononuclear leukocyte- 99mTc scintigraphy in the routine detection of infectious lesions and fever of unknown origin (FUO) in inpatients. Material and Methods: The use of mononuclear leukocyte 99mTc scintigraphy is presented in 87 patients who fulfilled the Durack and Street diagnostic criteria of nosocomial FUO; 66 patients were suspected of having infectious lesions (myocarditis, endocarditis, infected catheters, diabetic foot, and osteomyelitis) and 21 patients presented with unknown causes of FUO. Scans were carried out 1, 3, and 24 h after injection of labeled leukocytes. Results: In three cases (3/27) where scintigraphs were negative, biopsies were positive. There were two (2/87) false-positive scintigrams. We found a 95.8% sensitivity and 92.3% specificity. PPV was 93.8%, PPN 94.7%, and accuracy 94.2%. Conclusion: Mononuclear leukocyte 99mTc scintigraphy showed high sensitivity, specificity, positive and negative predictive values in patients with nosocomial FUO. These results suggest an important role for nuclear medicine in the management of patients with infection/inflammation.
On Asymptotic Analysis of Zero-Delay Energy-Distortion Tradeoff Under Additive White Gaussian Noise

Asymptotic energy-distortion performance of zero-delay communication scenarios under additive white Gaussian noise is investigated. Using high-resolution analysis for quantizer design, the higher-order term in the logarithm of the distortion (termed the {\em energy-distortion dispersion}) is optimized while keeping the leading term (i.e., {\em energy-distortion exponent}) at its optimal value. For uniform and Gaussian sources, significant gains are observed compared to na\"{i}vely performed quantization, i.e., aimed at optimizing the source coding performance instead of the end-to-end distortion in joint source-channel coding.
Time-Varying Gain Differentiator: A Mobile Hydraulic System Case Study

In mobile hydraulic systems, velocities are typically not measured. However, using their reliable estimates for feedback is known to allow designing better control laws. We are going to present a specialized technique to compute such estimates using measurements of positions and pressures in the chambers of hydraulic cylinders. With a rough estimate for an upper bound of the second derivative, computed online from pressures, the goal is to find the first derivative of the position signal in the presence of noise. We propose a differentiator with a continuous time-varying gain, constructed from pressure measurements, achieving chattering attenuation without compromising the performance of estimation. The gain is constructively tuned using analysis based on a time-varying Lyapunov function. In addition, the obtained ultimate bounds on differentiation errors provide a criterion for the enhancement of the precision of the proposed algorithm with a constructive design of its parameters. The experimental results over a forestry-standard mobile hydraulic crane confirm the advantages of the methodology.
Strategic Targeting

Virtually every government provides distributive transfers for electoral purposes. However, the level and form of such transfers vary dramatically across countries. Although transfers take many forms, they can generally be characterized as being either broad (providing benefits to large segments of the electorate) or narrow (targeting benefits only to select groups of voters). Variation in the form of distributive transfers across countries can be explained by voters' economic interests and domestic institutions. Voters' preferences over transfer form, shaped in part by the mobility of their assets, together with a country's electoral rules determine the benefits politicians gain from providing either broad or narrow transfers. Using new measures of transfer form, the author finds that although majoritarian systems are more prone to narrow transfers, proportional systems are more responsive to increases in voter demand for narrow transfers, all else equal.
Effects of Discharge Fan on the Drying Efficiency in Flat-bed type Dryer

— The study of interaction among the grain, moisture, and the surrounding space (air) is key to understanding the grain-drying process. In Iran, rice (mostly Indica type) is dried by flat bed type dryer until the final MC reaches to 6 to 8%. The experiments were conducted to examine the effect of application of discharge fan with different heights of paddy on the drying efficiency. Experiments were designed based on two different configurations of the drying methods; with and without discharge fan with three different heights of paddy including; 5, 10, and 15 cm. The humid heated air will be going out immediately by the suction of discharge fan. The drying time is established upon the average final MC to achieve about 8%. To save energy and reduce the drying time, the distribution of temperature between layers should be fast and uniform with minimum difference; otherwise the difference of MC gradient between layers will be high and will induce grain breakage. The difference of final MC between layers in the two methods was 48-73%. The steady state of temperature between the two methods has saved time in the range of 10-20%, and the efficiency of temperature distribution increased 17-26% by the use of discharge fan.
Morphology of inter-atrial conduction routes in patients with atrial fibrillation.

BACKGROUND Inter-atrial conduction disturbance is associated with the presence of atrial fibrillation (AF), although little is known about the anatomy of the inter-atrial connections. METHODS AND RESULTS Twenty-seven hearts from in-hospital deaths were examined and stratified in two groups with regard to their history of AF. Measurements of atrial weight were performed after excising the atria at the level of the atrioventricular valve plane and separation from the inter-atrial septum (IAS). In addition, in 15 of 27 hearts (seven AF, eight non-AF) the IAS was sliced into 10 microm thick parallel histological sections at intervals of 1 mm starting at the valve plane and ending at the atrial roof. The sections were stained with van Gieson's stain. The variable morphology of the anterior and posterior inter-atrial connective muscle bundles is described. The total number of inter-atrial connections varied from 1 to 5. The anterior route (Bachmann's bundle) was not found in seven of 15 specimens. CONCLUSION Inter-atrial connections are characterized by substantial variability in morphology and in the distribution of bundles. This may account for part of the variable susceptibility to AF.
Reshaping the University: Responsibility, Indigenous Epistemes, and the Logic of the Gift

Acknowledgments Preface Introduction 1 The Gift 2 From Cultural Conflicts to Epistemic Ignorance 3 The Question of Speaking and the Impossibility of the Gift 4 Knowing the "Other" and "Learning to Learn" 5 Hospitality and the Logic of the Gift in the Academy Conclusion Afterword Notes Bibliography Index
Participation of the immune system in regression of a rat Mc7 sarcoma by hyperthermia.

Participation of the host immune response in eradication of tumor by hyperthermia has been suspected for a long time. The effect of local tumor heating on the immunocompetence of rats bearing Mc7 sarcoma was studied. Following heat treatment of 1- to 1.5-ml foot tumors at 43 degrees for 2 hr, regression of primary tumors resulted in host cure (15 of 21; 71%), and this was accompanied by an increased skin response to both 3 M KCl extract of Mc7 and dinitrochlorobenzene as well as in elevation of antibody to bovine serum albumin. Animals that were cured by hyperthermia showed no sign of metastatic tumor in lymph nodes and lungs; most control animals at the time of heat treatment had secondary tumor deposits in lymph nodes and lungs. Tumor regression after curative heating did not occur in rats (0 to 10) treated by whole-body X-rays (150 R; 3 times) plus cortisone acetate (60 mg/kg; 4 times; s.c.), and the tumor cure rate was reduced (9 of 21; 43%) by blocking macrophage activity with silica (1 g/kg; i.v. and i.p.). Also, these rats (43%) succumbed to tumor challenge with 2.5 x 10(6) Mc7 cells; 50% of the heat-cured animals not given silica consistently rejected this challenge dose. The results imply that immunostimulation comprising mainly T-cells and macrophages plays a major part in tumor regression by hyperthermia.
Computation of Mean Drag for Bluff Body Problems Using Adaptive DNS/LES

We compute the time average of the drag in two benchmark bluff body problems: a surface mounted cube at Reynolds number 40000, and a square cylinder at Reynolds number 22000, using adaptive DNS/LES. In adaptive DNS/LES the Galerkin least-squares finite element method is used, with adaptive mesh refinement until a given stopping criterion is satisfied. Both the mesh refinement criterion and the stopping criterion are based on a posteriori error estimates of a given output of interest, in the form of a space-time integral of a computable residual multiplied by a dual weight, where the dual weight is obtained from solving an associated dual problem computationally, with the data of the dual problem coupling to the output of interest. No filtering is used, and in particular no Reynolds stresses are introduced. We thus circumvent the problem of closure, and instead we estimate the error contribution from subgrid modeling a posteriori, which we find to be small. We are able to predict the mean drag with an estimated tolerance of a few percent using about $10^5$ mesh points in space, with the computational power of a PC.
High-Level Clonal FGFR Amplification and Response to FGFR Inhibition in a Translational Clinical Trial.

UNLABELLED FGFR1 and FGFR2 are amplified in many tumor types, yet what determines response to FGFR inhibition in amplified cancers is unknown. In a translational clinical trial, we show that gastric cancers with high-level clonal FGFR2 amplification have a high response rate to the selective FGFR inhibitor AZD4547, whereas cancers with subclonal or low-level amplification did not respond. Using cell lines and patient-derived xenograft models, we show that high-level FGFR2 amplification initiates a distinct oncogene addiction phenotype, characterized by FGFR2-mediated transactivation of alternative receptor kinases, bringing PI3K/mTOR signaling under FGFR control. Signaling in low-level FGFR1-amplified cancers is more restricted to MAPK signaling, limiting sensitivity to FGFR inhibition. Finally, we show that circulating tumor DNA screening can identify high-level clonally amplified cancers. Our data provide a mechanistic understanding of the distinct pattern of oncogene addiction seen in highly amplified cancers and demonstrate the importance of clonality in predicting response to targeted therapy. SIGNIFICANCE Robust single-agent response to FGFR inhibition is seen only in high-level FGFR-amplified cancers, with copy-number level dictating response to FGFR inhibition in vitro, in vivo, and in the clinic. High-level amplification of FGFR2 is relatively rare in gastric and breast cancers, and we show that screening for amplification in circulating tumor DNA may present a viable strategy to screen patients. Cancer Discov; 6(8); 838-51. ©2016 AACR.This article is highlighted in the In This Issue feature, p. 803.