Miracle-dz/UniFAR-FTUs huggingface dataset:
Differences Between Women With Traumatic and Idiopathic Chronic Neck Pain and Women Without Neck Pain: Interrelationships Among Disability, Cognitive Deficits, and Central Sensitization

Background To date, a clear differentiation of disability, cognitive deficits, and central sensitization between chronic neck pain of a traumatic nature and that of a nontraumatic nature is lacking. Objective This study aimed to examine differences in disability, cognitive deficits, and central sensitization between women with traumatic and idiopathic (nontraumatic) chronic neck pain and women who were healthy. In addition, interrelationships among these variables were investigated. Design This was a case-control study. Methods Ninety-five women (28 women who were healthy [controls], 35 women with chronic idiopathic neck pain [CINP], and 32 women with chronic whiplash-associated disorders [CWAD] [traumatic]) were enrolled in the study. First, all participants completed standardized questionnaires to investigate pain-related disability and health-related quality of life. Next, cognitive performance was assessed. Finally, pressure pain thresholds and conditioned pain modulation were examined to investigate central sensitization. Results Pain-related disability, reduced health-related quality of life, and cognitive deficits were present in participants with CWAD and, to a significantly lesser extent, in participants with CINP. Local hyperalgesia was demonstrated in participants with CWAD and CINP but not in women who were healthy. However, distant hyperalgesia and decreased conditioned pain modulation efficacy were shown only in participants with CWAD; this result is indicative of the presence of central sensitization. Moderate to strong Spearman correlations (ρ=.456-.701) among disability, cognitive deficits, and hyperalgesia (local and distant) were observed in participants with CWAD. In participants with CINP, only local hyperalgesia and subjective cognitive deficits were moderately (ρ=.463) correlated. Limitations No conclusions about the causality of the observed correlations can be drawn. Conclusions This innovative research revealed important differences between women with CWAD and women with CINP and thus provided evidence of the clinical importance of distinguishing the assessment and rehabilitation approaches for both pain conditions.
Prenatal Exposure to Perfluoroalkyl Substances and Body Fatness in Girls.

BACKGROUND Perfluoroalkyl substances (PFASs) are used in surface coatings that resist stains, grease, and water. METHODS The association between in utero PFAS exposure and girls' body fatness at age 9 was analyzed in The Avon Longitudinal Study of Parents and Children (UK). Maternal serum [median 15 weeks: interquartile range (IQR) 10 and 28 weeks of gestation] was analyzed for perfluorooctane sulfonate (PFOS), perfluorooctanoate (PFOA), perfluorohexane sulfonate (PFHxS), and perfluorononanoate (PFNA). Body composition was measured by dual X-ray emission absorptiometry, and percent total body fat (%BF) was calculated. Associations between PFASs and body fatness were modeled by multivariable linear regression. RESULTS Among 359 girls, median (IQR) %BF was 27.5 (IQR 21.7-34.6). Median (IQR) concentrations (all ng/mL) were 3.7 (2.9-4.8) for PFOA, 19.8 (15.0-25.3) for PFOS, 1.6 (1.3-2.2) for PFHxS, and 0.5 (0.4-0.7) for PFNA. Maternal PFAS concentrations were not significantly associated with daughters' total %BF overall. Mothers' educational status modified associations for PFOA and PFOS with %BF (P-interactions: 0.005 and 0.02, respectively). %BF was higher [1.4%; 95% confidence interval (95% CI): 0.3 to 2.5] for each one unit (ng/mL) higher PFOA among girls with mothers in the middle education group, but lower (-0.6%; 95% CI: -1.12 to -0.04) for the corresponding comparison among girls with mothers with the highest education. %BF was lower (-0.2%; 95% CI: -0.3 to -0.1) for each one unit higher PFOS among girls with the most educated mothers. CONCLUSIONS Prenatal exposure to PFOA and PFOS was associated with girls' %BF within some strata of maternal education status. PFHxS and PFNA were not associated with %BF.
Dynamic hip screw with locked plate VRS Proximal Femoral Nail for the management of intertrochanteric fracture: A comparative study

Dynamic hip screw has long been a standard implant for intertrochanteric hip fractures. The inception of intramedullary nails has further revolutionized their management. With a constant evolution in the designs of both these implants, there has always been a conflict concerning the superiority of one over the other. In this randomized prospective cohort study, 80 patients with intertrochanteric fracture femur were segregated into two groups based on internal fixation with DHS with locking side plate (DHS) (n=40) or Proximal femoral Nail (PFN) (n=40). Clinical and radiological parameters were studied and functional evaluation was done with Harris hip score. The intraoperative parameters were in favor of PFN with significantly less duration of surgery, length of incision and blood loss but more fluoroscopy time. Postoperatively also, PFN group patients excelled with significantly less postoperative pain, less incidence of deep infection , better range of motion, less mean limb length discrepancy and more patients regaining their pre injury walking capability and also fewer complications. Average union time was comparable between the groups. Functionally, PFN emerged to be superior to DHS in unstable intertrochanteric fractures while in stable fractures, results were same. We deduce that surgical planning and expertise with rigorous regard to the personality of the fracture are pivotal for outstanding results.
Thermoluminescent Neutron Dosimetry

A literature review and the present status of thermoluminescent neutron dosimetry are presented. The theory on thermoluminescent dosimetry is given in detail. The applications of thermoluminescence phenomenon in thermal neutron dosimetry, in fast neutron dosimetry, and in mixed field dosimetry are discussed. Some experimental results are included. The prospective use of thermoluminescent dosimeters in other nuclear detection or measurement is also given.
Adenoviral intramyocardial VEGF-DΔNΔC gene transfer increases myocardial perfusion reserve in refractory angina patients: a phase I/IIa study with 1-year follow-up

Abstract Aims We evaluated for the first time the effects of angiogenic and lymphangiogenic AdVEGF-DΔNΔC gene therapy in patients with refractory angina. Methods and results Thirty patients were randomized to AdVEGF-DΔNΔC (AdVEGF-D) or placebo (control) groups. Electromechanical NOGA mapping and radiowater PET were used to identify hibernating viable myocardium where treatment was targeted. Safety, severity of symptoms, quality of life, lipoprotein(a) [Lp(a)] and routine clinical chemistry were measured. Myocardial perfusion reserve (MPR) was assessed with radiowater PET at baseline and after 3- and 12-months follow-up. Treatment was well tolerated. Myocardial perfusion reserve increased significantly in the treated area in the AdVEGF-D group compared with baseline (1.00 ± 0.36) at 3 months (1.31 ± 0.46, P = 0.045) and 12 months (1.44 ± 0.48, P = 0.009) whereas MPR in the reference area tended to decrease (2.05 ± 0.69, 1.76 ± 0.62, and 1.87 ± 0.69; baseline, 3 and 12 months, respectively, P = 0.551). Myocardial perfusion reserve in the control group showed no significant change from baseline to 3 and 12 months (1.26 ± 0.37, 1.57 ± 0.55, and 1.48 ± 0.48; respectively, P = 0.690). No major changes were found in clinical chemistry but anti-adenovirus antibodies increased in 54% of the treated patients compared with baseline. AdVEGF-D patients in the highest Lp(a) tertile at baseline showed the best response to therapy (MPR 0.94 ± 0.32 and 1.76 ± 0.41 baseline and 12 months, respectively, P = 0.023). Conclusion AdVEGF-DΔNΔC gene therapy was safe, feasible, and well tolerated. Myocardial perfusion increased at 1 year in the treated areas with impaired MPR at baseline. Plasma Lp(a) may be a potential biomarker to identify patients that may have the greatest benefit with this therapy.
Effects of mesoscale eddy/wind interactions on biological new production and eddy kinetic energy

Accounting for ocean currents in the bulk parameterization of the wind stress might represent a physically more plausible way to force an ocean model than ignoring their effect. We show in this study that using the air-sea velocity difference instead of the atmospheric wind in the wind stress formulation dampens both the near-surface eddy activity and the biotic carbon assimilation in a high-resolution model of the North Atlantic. The former is significant, corresponding to a reduction down to 50% in the tropical Atlantic, while in higher latitudes (in agreement with previous results) the reduction of eddy activity is only around 10%. The effect on biotically mediated new production and air-sea carbon fluxes is, on the other hand, minor. New production is reduced by less than 5% on a basin average, while simulated air-sea CO2 fluxes are barely affected at all. The model results imply that eddy/wind interaction introduced by accounting for ocean currents in the wind stress formulation does not drive any additional (and hitherto unaccounted) nutrient fluxes to the sunlit surface of the subtropical gyre, as was recently proposed in the literature.
Assessing the hydration status of children with chronic kidney disease and on dialysis: a comparison of techniques

Background Fluid balance is pivotal in the management of children with chronic kidney disease (CKD) and on dialysis. Although many techniques are available to assess fluid status, there are only a few studies for children, of which none have been comparable against cardiovascular outcome measures. Methods We performed a longitudinal study in 30 children with CKD5-5D and 13 age-matched healthy controls (71 measurements) to determine a correlation between optimal weight by bioimpedance spectroscopy (Wt-BIS) and clinical assessment (Wt-CA). The accuracy of Wt-BIS [relative overhydration (Rel-OH)] was compared against indicators of fluid status and cardiovascular measures. Results There was poor agreement between Wt-CA and Wt-BIS in children on dialysis (P = 0.01), but not in CKD5 or control subjects. We developed a modified chart to plot Rel-OH against systolic blood pressure (SBP) z-score for the appropriate representation of volume status and blood pressure (BP) in children. In total, 25% of measurements showed SBP >90th percentile but not with concurrent overhydration. Rel-OH correlated with peripheral pulse pressure (P = 0.03; R = 0.3), higher N-terminal pro-brain natriuretic peptide (P = 0.02; R = 0.33) and left ventricular end-diastolic diameter (P = 0.05; R = 0.38). Central aortic mean and pulse pressure significantly associated with the left ventricular end-diastolic diameter (P = 0.03; R = 0.47 and P = 0.01; R = 0.50, respectively), but not with Rel-OH. SBP was positively associated with pulse wave velocity z-score (P = 0.04). In total, 40% of children on haemodialysis and 30% on peritoneal dialysis had increased left ventricular mass index. Conclusions BIS provides an objective method for the assessment of hydration status in children on dialysis. We noted a marked discrepancy between BP and hydration status in children on dialysis that warrants further investigation.
Ablation of Arginylation in the Mouse N-End Rule Pathway: Loss of Fat, Higher Metabolic Rate, Damaged Spermatogenesis, and Neurological Perturbations

In the N-end rule pathway of protein degradation, the destabilizing activity of N-terminal Asp, Glu or (oxidized) Cys residues requires their conjugation to Arg, which is recognized directly by pathway's ubiquitin ligases. N-terminal arginylation is mediated by the Ate1 arginyltransferase, whose physiological substrates include the Rgs4, Rgs5 and Rgs16 regulators of G proteins. Here, we employed the Cre-lox technique to uncover new physiological functions of N-terminal arginylation in adult mice. We show that postnatal deletion of mouse Ate1 (its unconditional deletion is embryonic lethal) causes a rapid decrease of body weight and results in early death of ∼15% of Ate1-deficient mice. Despite being hyperphagic, the surviving Ate1-deficient mice contain little visceral fat. They also exhibit an increased metabolic rate, ectopic induction of the Ucp1 uncoupling protein in white fat, and are resistant to diet-induced obesity. In addition, Ate1-deficient mice have enlarged brains, an enhanced startle response, are strikingly hyperkinetic, and are prone to seizures and kyphosis. Ate1-deficient males are also infertile, owing to defects in Ate1−/− spermatocytes. The remarkably broad range of specific biological processes that are shown here to be perturbed by the loss of N-terminal arginylation will make possible the dissection of regulatory circuits that involve Ate1 and either its known substrates, such as Rgs4, Rgs5 and Rgs16, or those currently unknown.
Health-related quality of life and its determinants in paediatric arterial ischaemic stroke survivors

Objective Health-related quality of life (HRQL) instruments are patient or proxy-reported outcome measures that provide a comprehensive and subjective assessment of patient’s well-being and hence vital for health outcomes evaluation. A clear and thorough understanding of HRQL and its determinants is especially important to appropriately guide health-improving interventions. In this study, HRQL of paediatric arterial ischaemic stroke survivors was assessed using guidelines recommended for interpretation and reporting of the patient-reported outcome data. Determinants of HRQL were also explored. Methods Children diagnosed with arterial ischaemic stroke between 2003 and 2012 were assessed at least 1 year poststroke using the parent–proxy report versions of the Pediatric Quality of Life Inventory 4.0 and Pediatric Stroke Recurrence and Recovery Questionnaire. HRQL data were compared with population norms and used as outcome in multiple linear regression analysis. Results 59 children were evaluated. Mean age at diagnosis of stroke was 2.2 years. Mean age at assessment and time elapsed since stroke was 7 years and 5 years, respectively. A total of 41% children had normal global outcome, whereas 51% had moderate to severe deficits. A lower overall HRQL was observed in both self and proxy reports. Parents reported the maximum impairment in emotional domain, whereas children indicated physical functioning to be the most affected. Neurological outcome, site of stroke and socioeconomic status were independently associated with overall HRQL. Conclusions Lower HRQL was demonstrated in children who survived arterial ischaemic stroke. Socioeconomic status of families was an important determinant of HRQL, over and above clinical parameters.
Wrist-Powered Partial Hand Prosthesis Using a Continuum Whiffle Tree Mechanism: A Case Study

Among the advances in upper extremity prostheses in the past decades, only a small portion of the results were obtained for partial hand prostheses, possibly due to the highly diverse partial hand presentations and limited space for component integration. In an attempt to address these challenges, this paper presents the design, construction, installation, and experimental characterization of a wrist-powered partial hand prosthesis developed in Shanghai Jiao Tong University (hereafter referred to as the JTP hand), customized for a specific amputee. The JTP hand possesses: 1) a continuum whiffle tree mechanism to allow adaptive grasping; 2) a force-magnifying partial gear pair to enhance the power of the grip; and 3) a phalange-embedded disengageable ratchet to enable or disable backdrivability. Various grasps and gestures were formed using the JTP hand. The obtained results suggest that the proposed design might be a viable option for patients with transmetacarpal amputation.
Simulations of Multi-Phase Particle Deposition on Endwall Film-Cooling Holes in Transverse Trenches

Integrated gasification combined cycle (IGCC) power plants allow for increased efficiency and reduced emissions as compared to pulverized coal plants. A concern with IGCCs is that impurities in the fuel from the gasification of coal can deposit on turbine components reducing the performance of sophisticated film-cooling geometries. Studies have shown that recessing a row of film-cooling holes in a transverse trench can improve cooling performance; however, the question remains as to whether or not these improvements exist in severe environments such as when particle deposition occurs. Dynamic simulations of deposition were completed using wax injection in a large-scale vane cascade with endwall film-cooling. Endwall cooling effectiveness was quantified in two specific endwall locations using trenches with depths of 0.4D, 0.8D, and 1.2D, where D is the diameter of a film-cooling hole. The effects of trench depth, momentum flux ratio, and particle phase on adiabatic effectiveness were quantified using infrared thermography. Results showed that the 0.8D trench outperformed other geometries with and without deposition on the surface. Deposition of particles reduced the cooling effectiveness by as much as 15% at I = 0.23 with the trenched holes as compared to 30% for holes that were not placed in a transverse trench.Copyright © 2011 by ASME
Competition for the focus of attention in visual working memory: perceptual recency versus executive control

Previous research on memory for a short sequence of visual stimuli indicates that access to the focus of attention (FoA) can be achieved in either of two ways. The first is automatic and is indexed by the recency effect, the enhanced retention of the final item. The second is strategic and based on instructions to prioritize items differentially, a process that draws on executive capacity and boosts retention of information deemed important. In both cases, the increased level of retention can be selectively reduced by presenting a poststimulus distractor (or suffix). We manipulated these variables across three experiments. Experiment 1 generalized previous evidence that prioritizing a single item enhances its retention and increases its vulnerability to interference from a poststimulus suffix. A second experiment showed that the enhancement from prioritizing one or two items comes at a cost to the recency effect. A third experiment showed that prioritizing two items renders memory for both vulnerable to interference from an irrelevant suffix. The results suggest that some but not all items in working memory compete to occupy a narrow FoA and that this competition is determined by a combination of perceptually driven recency and internal executive control.
Sharing Family Life Information Through Video Calls and Other Information and Communication Technologies and the Association With Family Well-Being: Population-Based Survey

Background The use of information and communication technologies (ICTs) for information sharing among family members is increasing dramatically. However, little is known about the associated factors and the influence on family well-being. Objective The authors investigated the pattern and social determinants of family life information sharing with family and the associations of different methods of sharing with perceived family health, happiness, and harmony (3Hs) in Hong Kong, where mobile phone ownership and Internet access are among the most prevalent, easiest, and fastest in the world. Methods A territory-wide population-based telephone survey was conducted from January to August 2016 on different methods of family life information (ie, information related to family communication, relationships with family members, emotion and stress management) sharing with family members, including face-to-face, phone, instant messaging (IM), social media sites, video calls, and email. Family well-being was assessed by three single items on perceived family health, happiness, and harmony, with higher scores indicating better family well-being. Adjusted prevalence ratios were used to assess the associations of sociodemographic factors with family life information sharing, and adjusted beta coefficients for family well-being. Results Of 2017 respondents, face-to-face was the most common method to share family life information (74.45%, 1502/2017), followed by IM (40.86%, 824/2017), phone (28.10%, 567/2017), social media sites (11.91%, 240/2017), video calls (5.89%, 119/2017), and email (5.48%, 111/2017). Younger age and higher education were associated with the use of any (at least one) method, face-to-face, IM, and social media sites for sharing family life information (all P for trend <.01). Higher education was most strongly associated with the use of video calls (adjusted prevalence ratio=5.61, 95% CI 2.29-13.74). Higher household income was significantly associated with the use of any method, face-to-face, and IM (all P for trend <.05). Sharing family life information was associated with a higher level of perceived family well-being (beta=0.56, 95% CI 0.37-0.75), especially by face-to-face (beta=0.62, 95% CI 0.45-0.80) and video calls (beta=0.34, 95% CI 0.04-0.65). The combination of face-to-face and video calls was most strongly associated with a higher level of perceived family well-being (beta=0.81, 95% CI 0.45-1.16). Conclusions The differential use of ICTs to share family life information was observed. The prevalence of video calls was low, but associated with much better family well-being. The results need to be confirmed by prospective and intervention studies to promote the use of video calls to communicate and share information with family, particularly in disadvantaged groups.
Premature termination of radiofrequency delivery during pulmonary vein isolation due to oesophageal temperature alerts: impact on acute and chronic pulmonary vein reconnection

Aims Oesophageal temperature monitoring is currently used during atrial fibrillation (AF) ablation to prevent atrio-oesophageal fistula. The aim of our study was to investigate if oesophageal temperature alerts, leading to early termination of radiofrequency (RF) energy and/or reduction in power during pulmonary vein isolation, can promote pulmonary vein reconnection (PVR). Methods and results Patients undergone two consecutive AF ablation procedures with a three-dimensional electro-anatomical mapping system and oesophageal temperature monitoring were studied. Any lesions causing oesophageal temperature rises >39°C during the index procedure, leading to premature cessation of RF and/or reduction in power, were labelled on the left atrial geometry in a different colour from standard uninterrupted RF lesions. Acute (at the time of the index procedure) and chronic (at the time of there-do procedure) PVR and the site of subsequent re-isolation were compared with the lesion markers for temperature alerts from the index procedure. Fifty-four patients were included (36 male, mean age 68 ± 8, 59% persistent AF). Forty-six PVs (21% of the total) in 30 patients (56%) had been subject to at least one temperature alert during the index procedure. In 12 patients, 23 PVs had acute PVR requiring further ablation. At the re-do procedure, 103 PVs were found to be reconnected in 44 patients. No correlation was found between the occurrence of temperature alerts at the index procedure and acute or chronic PVR in the associated PV. Conclusion Just over half of patients undergoing PV isolation will have an oesophageal temperature alert, however, precautionary oesophageal temperature monitoring does not compromise ablation efficacy.