Miracle-dz/UniFAR-FTUs huggingface dataset:
A ug 2 00 8 Higher dimensional Kerr-Schild spacetimes

We investigate general properties of Kerr-Schild (KS) metrics in n > 4 spacetime dimensions. First, we show that the Weyl tensor is of type II or more special if the null KS vector k is geodetic (or, equivalently, if Tabk k = 0). We subsequently specialize to vacuum KS solutions, which naturally split into two families of non-expanding and expanding metrics. After demonstrating that non-expanding solutions are equivalent to the known class of vacuum Kundt solutions of type N, we analyze expanding solutions in detail. We show that they can only be of the type II or D, and we characterize optical properties of the multiple Weyl aligned null direction (WAND) k. In general, k has caustics corresponding to curvature singularities. In addition, it is generically shearing. Nevertheless, we arrive at a possible “weak” n > 4 extension of the Goldberg-Sachs theorem, limited to the KS class, which matches previous conclusions for general type III/N solutions. In passing, properties of Myers-Perry black holes and black rings related to our results are also briefly discussed.
α-Synuclein Genetic Variants Predict Faster Motor Symptom Progression in Idiopathic Parkinson Disease

Currently, there are no reported genetic predictors of motor symptom progression in Parkinson’s disease (PD). In familial PD, disease severity is associated with higher α-synuclein (SNCA) expression levels, and in postmortem studies expression varies with SNCA genetic variants. Furthermore, SNCA is a well-known risk factor for PD occurrence. We recruited Parkinson’s patients from the communities of three central California counties to investigate the influence of SNCA genetic variants on motor symptom progression in idiopathic PD. We repeatedly assessed this cohort of patients over an average of 5.1 years for motor symptom changes employing the Unified Parkinson’s Disease Rating Scale (UPDRS). Of 363 population-based incident PD cases diagnosed less than 3 years from baseline assessment, 242 cases were successfully re-contacted and 233 were re-examined at least once. Of subjects lost to follow-up, 69% were due to death. Adjusting for covariates, risk of faster decline of motor function as measured by annual increase in motor UPDRS exam score was increased 4-fold in carriers of the REP1 263bp promoter variant (OR 4.03, 95%CI:1.57–10.4). Our data also suggest a contribution to increased risk by the G-allele for rs356165 (OR 1.66; 95%CI:0.96–2.88), and we observed a strong trend across categories when both genetic variants were considered (p for trend = 0.002). Our population-based study has demonstrated that SNCA variants are strong predictors of faster motor decline in idiopathic PD. SNCA may be a promising target for therapies and may help identify patients who will benefit most from early interventions. This is the first study to link SNCA to motor symptom decline in a longitudinal progression study.
Intracortical myelination in musicians with absolute pitch: Quantitative morphometry using 7‐T MRI

Absolute pitch (AP) is known as the ability to recognize and label the pitch chroma of a given tone without external reference. Known brain structures and functions related to AP are mainly of macroscopic aspects. To shed light on the underlying neural mechanism of AP, we investigated the intracortical myeloarchitecture in musicians with and without AP using the quantitative mapping of the longitudinal relaxation rates with ultra‐high‐field magnetic resonance imaging at 7 T. We found greater intracortical myelination for AP musicians in the anterior region of the supratemporal plane, particularly the medial region of the right planum polare (PP). In the same region of the right PP, we also found a positive correlation with a behavioral index of AP performance. In addition, we found a positive correlation with a frequency discrimination threshold in the anterolateral Heschl's gyrus in the right hemisphere, demonstrating distinctive neural processes of absolute recognition and relative discrimination of pitch. Regarding possible effects of local myelination in the cortex and the known importance of the anterior superior temporal gyrus/sulcus for the identification of auditory objects, we argue that pitch chroma may be processed as an identifiable object property in AP musicians. Hum Brain Mapp 37:3486–3501, 2016. © 2016 Wiley Periodicals, Inc.
Labelling Topics using Unsupervised Graph-based Methods

This paper introduces an unsupervised graph-based method that selects textual labels for automatically generated topics. Our approach uses the topic keywords to query a search engine and generate a graph from the words contained in the results. PageRank is then used to weigh the words in the graph and score the candidate labels. The state-of-the-art method for this task is supervised (Lau et al., 2011). Evaluation on a standard data set shows that the performance of our approach is consistently superior to previously reported methods.
Localization of matrix metalloproteinases on endometrial cancer cell invasion in vitro.

OBJECTIVES In this study, we have established an in vitro three-dimensional (3D) coculture, where normal endometrial stromal cells and endometrial cancer cells were cocultured under defined hormonal conditions, to investigate the potential paracrine effects on synthesis and secretion of matrix metalloproteinases (MMPs) and, thus, cancer invasion. METHODS Endometrial stromal cells were obtained by biopsy, cultured in the presence of 100 nM estrogen for 3 days, and then mixed with extracellular matrix (ECM) composed of collagen I and matrigel in a 4:1 ratio. After 3 more days in culture, a 3D coculture was established with HEC-1A cells, an endometrial adenocarcinoma cell line, grown on top of the mixture under various ovarian steroids (no steroid, 100 nM beta-estradiol (E2), or 1.0 microM progesterone (P4)) for 10 days. The expression and localization of MMP-2, MMP-9, and integrin beta 3 subunit were visualized by immunocytochemistry and analyzed by reverse transcription polymerase chain reaction (RT-PCR). The extent of cancer invasion was quantified by Boyden's chamber assay. RESULTS Integrin beta 3 subunit was localized along the cell surface of HEC-1A cell under all three hormonal conditions. MMP-2 was located in the cytoplasm of stromal cells and on the surface of HEC-1A cells. Synthesis and secretion of stromal MMP-2 were increased in the presence of ovarian steroids. In contrast, expression of stromal MMP-9 was suppressed in the presence of ovarian steroids. No MMPs were synthesized in HEC-1A cells. Invasion assay revealed that HEC-1A cells achieved high tumoral invasiveness in the presence of beta-estradiol. CONCLUSIONS These findings suggest that stromal cell-derived MMP-2 is translocated to the surface of HEC-1A cells. Integrin beta 3 subunit might contribute, in part, to providing a binding site for MMP-2. Thus, HEC-1A cells invade by recruiting MMP-2 secreted by stromal cells, which is greatly enhanced in the presence of beta-estradiol. The 3D coculture provides an excellent experimental system in which single parameters can be isolated from a complex in vivo system in the process of endometrial cancer invasion.
Maybes Mean ( Mostly ) the Same Thing April 14 , 2003

At the core of soft computing is the intuition that from imprecise knowledge, we can still make reasonable inferences. This paper offers experimental and mathematical evidence for this intuition. Based on a literature review and a newly developed mathematics of " reachability " , it is argued that searches through a space containing uncertainties, most of the reachable conclusions will be reached via a small number of " master variables " in a " narrow funnel ". Such narrow funnels can be found using very simple randomized search methods.
Comparison of the Oral Microbiomes of Canines and Their Owners Using Next-Generation Sequencing

The oral microbiome, which is closely associated with many diseases, and the resident pathogenic oral bacteria, which can be transferred by close physical contact, are important public health considerations. Although the dog is the most common companion animal, the composition of the canine oral microbiome, which may include human pathogenic bacteria, and its relationship with that of their owners are unclear. In this study, 16S rDNA pyrosequencing was used to compare the oral microbiomes of 10 dogs and their owners and to identify zoonotic pathogens. Pyrosequencing revealed 246 operational taxonomic units in the 10 samples, representing 57 genera from eight bacterial phyla. Firmicutes (57.6%), Proteobacteria (21.6%), Bacteroidetes (9.8%), Actinobacteria (7.1%), and Fusobacteria (3.9%) were the predominant phyla in the human oral samples, whereas Proteobacteria (25.7%), Actinobacteria (21%), Bacteroidetes (19.7%), Firmicutes (19.3%), and Fusobacteria (12.3%) were predominant in the canine oral samples. The predominant genera in the human samples were Streptococcus (43.9%), Neisseria (10.3%), Haemophilus (9.6%), Prevotella (8.4%), and Veillonella (8.1%), whereas the predominant genera in the canine samples were Actinomyces (17.2%), Unknown (16.8), Porphyromonas (14.8), Fusobacterium (11.8), and Neisseria (7.2%). The oral microbiomes of dogs and their owners were appreciably different, and similarity in the microbiomes of canines and their owners was not correlated with residing in the same household. Oral-to-oral transfer of Neisseria shayeganii, Porphyromonas canigingivalis, Tannerella forsythia, and Streptococcus minor from dogs to humans was suspected. The finding of potentially zoonotic and periodontopathic bacteria in the canine oral microbiome may be a public health concern.
Optimal Auctions for Multi-Unit Procurement with Volume Discount Bids

Our attention is focused on designing an optimal procurement mechanism which a buyer can use for procuring multiple units of a homogeneous item based on bids submitted by autonomous, rational, and intelligent suppliers. We design elegant optimal procurement mechanisms for two different situations. In the first situation, each supplier specifies the maximum quantity that can be supplied together with a per unit price. For this situation, we design an optimal mechanism S-OPT (Optimal with Simple bids). In the more generalized case, each supplier specifies discounts based on the volume of supply. In this case, we design an optimal mechanism VD-OPT (Optimal with Volume Discount bids). The VD-OPT mechanism uses the S-OPT mechanism as a building block. The proposed mechanisms minimize the cost to the buyer, satisfying at the same time, (a) Bayesian incentive compatibility and (b) interim individual rationality.
The Right Job and the Job Right: Novelty, Impact and Journal Stratification in Science

Though Science is traditionally associated with creative behavior, concerns have been raised on its professional procedures being suyciently open to innovative re-search. Thanks to a new measurement of novelty based on the frequencies of pair-wise combinations of article keywords calculated on the set of all research articles published from 1999 to 2013 in the journals referenced by the WoS (more than ten million papers), we find no evidence of shrinking novelty in science over that pe-riod. Novel contributions are more often performed in larger teams that span more institutional boundaries and geographic areas. High novelty increases citations by more than forty percent and the odds of a “big hit” by about fifty percent. High novelty simultaneously reduces citational risk conditioned on being published to a large extent because it rises the odds of the problem remaining active in the future. As we document that novel papers match preferentially with top journals (even controlling for journal quality), the risk induced by novel research is more likely to materialize through the publication process.
The structure of the nuclear stellar cluster of the Milky Way

Abstract High-resolution adaptive optics observations of the inner 0.5 pc of the Milky Way with multiple intermediate band filters are presented. From the images, stellar number counts and a detailed map of the interstellar extinction were extracted. The extinction map is consistent with a putative southwest-northeast aligned outflow from the central arcseconds. An azimuthally averaged, crowding and extinction corrected stellar density profile presents clear evidence for the existence of a stellar cusp around Sgr A*. Several density peaks are found in the cluster that may indicate clumping of stars, possibly related to the last epoch of star formation in the Galactic Center. An analysis of stars in the brightness range 14.25 < magK < 15.75 shows possible signs of mass segregation.
The relationship between cooling flows and metallicity measurements for X-ray-luminous clusters

ABSTRA C T We explore the relationship between the metallicity of the intracluster gas in clusters of galaxies, determined by X-ray spectroscopy, and the presence of cooling flows. Using ASCA spectra and ROSAT images, we demonstrate a clear segregation between the metallicities of clusters with and without cooling flows. On average, cooling-flow clusters have an emissionweighted metallicity a factor ,1:8 times higher than that of non-cooling-flow systems. We suggest that this is caused by the presence of metallicity gradients in the cooling-flow clusters, coupled with the sharply peaked X-ray surface brightness profiles of these systems. Noncooling-flow clusters have much flatter X-ray surface brightness distributions and are thought to have undergone recent merger events, which may have mixed the central high-metallicity gas with the surrounding less metal-rich material. We find no evidence for evolution in the emission-weighted metallicities of clusters within z , 0:3.
The Vibrio cholerae Cytolysin Promotes Chloride Secretion from Intact Human Intestinal Mucosa

Background The pathogenicity of the Vibrio cholerae strains belonging to serogroup O1 and O139 is due to the production of virulence factors such as cholera toxin (CT) and the toxin-coregulated pilus (TCP). The remaining serogroups, which mostly lack CT and TCP, are more frequently isolated from aquatic environmental sources than from clinical samples; nevertheless, these strains have been reported to cause human disease, such as sporadic outbreaks of watery diarrhoea and inflammatory enterocolitis. This evidence suggested the possibility that other virulence factor(s) than cholera toxin might be crucial in the pathogenesis of Vibrio cholerae-induced diarrhoea, but their nature remains unknown. VCC, the hemolysin produced by virtually all Vibrio cholerae strains, has been proposed as a possible candidate, though a clear-cut demonstration attesting VCC as crucial in the pathogenesis of Vibrio cholerae-induced diarrhoea is still lacking. Methodology/Principal Findings Electrophysiological parameters and paracellular permeability of stripped human healthy colon tissues, obtained at subtotal colectomy, mounted in Ussing chamber were studied in the presence or absence of VCC purified from culture supernatants of V. cholerae O1 El Tor strain. Short circuit current (ISC) and transepithelial resistance (RT) were measured by a computerized voltage clamp system. The exposure of sigmoid colon specimens to 1 nM VCC resulted in an increase of ISC by 20.7%, with respect to the basal values, while RT was reduced by 12.3%. Moreover, increase in ISC was abolished by bilateral Cl− reduction. Conclusion/Significance Our results demonstrate that VCC, by forming anion channels on the apical membrane of enterocytes, triggers an outward transcellular flux of chloride. Such an ion movement, associated with the outward movement of Na+ and water, might be responsible for the diarrhoea caused by the non-toxigenic strains of Vibrio cholerae.
On the null space of a Colin de Verdière matrix

An exercise apparatus having a frame with a predetermined reference position, an engagement assembly for use by an operator during exercise, a system for resisting movement of the engagement assembly by the operator during exercise and a mechanism mounting the engagement assembly for selective movement along a path of travel relative to the reference position for purposes of controlling the exercise of the operator positioned relative to the reference position.
Assessing the Effects of UTAUT and Self-Determination Predictor on Students Continuance Intention to Use Student Portal

Higher Education Institution, with the advent of information system technology, is putting in an effort to introduce a student portal system for use by students. Continued usage considered as a measure of success in information system implementation. The objective of this study is to propose an integrated research framework to investigate the factors that can motivate students to continue to utilize UCSA student portal system. Two streams of research provide the basis for this integrated framework namely Unified theory of acceptance and use of technology (UTAUT) and Self-Determination theory. A total sample of 279 students from UCSA (University College ShahPutra) responded to 20-item questionnaires containing 6 constructs: continuance intention to use, performance expectancy, effort expectancy, social influence, facilitating condition and intrinsic motivation. Covariance-based SEM (Structural Equation Modeling) was employed as the main method of analysis. Results revealed that the performance expectancy and intrinsic motivation do not have any statistically significant effect on continuance intention to use UCSA student portal. However, effort expectancy, social influence and facilitating condition were shown to significantly influence continuance intention. The model which derived from the data explained 53 % of variance of student portal continuance intention.
Social self-organization : agent-based simulations and experiments to study emergent social behavior

Modeling of Socio-Economic Systems. - Agent-based modeling. - Self-Organization in Pedestrian Crowds. - Opinion Formation. - Spatial Self-Organization through Success-Driven Mobility. - Cooperation in Social Dilemmas. - Co-Evolution of Social Behavior and Spatial Organization. - Evolution of Moral Behavior. - Coordination and Competitive Innovation Spreading in Social Networks. - Heterogeneous Populations: Coexistence, Integration, or Conflict. - Social Experiments and Computers. - Learning of Coordinated Behavior. - Response to Information. - Systemic Risks in Society and Economics. - Managing Complexity. - Challenges in Economics.
Proposal of a Nutritional Quality Index (NQI) to Evaluate the Nutritional Supplementation of Sportspeople

Background Numerous supplements are used by sportspeople. They are not always appropriate for the individual or the sports activity and may do more harm than good. Vitamin and mineral supplements are unnecessary if the energy intake is sufficient to maintain body weight and derives from a diet with an adequate variety of foods. The study objectives were to evaluate the main nutrients used as supplements in sports and to propose a nutritional quality index (NQI) that enables sportspeople to optimize their use of supplements and detect and remedy possible nutritional deficits. Material and Methods A nutritional study was performed in 485 sportspeople recruited from Centros Andaluces de Medicina del Deporte, (CAMD). All completed socio-demographic, food frequency, and lifestyle questionnaires. The nutritional quality of their diet and need for supplementation were evaluated by scoring their dietary intake with and without supplementation, yielding two NQI scores (scales of 0-21 points) for each participant. Results A superior mean NQI score was obtained when the supplements taken by participants were not included (16. 28 (SD of 3.52)) than when they were included (15.47 (SD: 3.08)), attributable to an excessive intake of some nutrients through supplementation. Conclusions These results indicate that sportspeople with a varied and balanced diet do not need supplements, which appear to offer no performance benefits and may pose a health risk.
Recommendation by Mining Multiple User Behaviors with Group Sparsity

Recently, some recommendation methods try to improvethe prediction results by integrating informationfrom user’s multiple types of behaviors. How to modelthe dependence and independence between differentbehaviors is critical for them. In this paper, we proposea novel recommendation model, the Group-Sparse MatrixFactorization (GSMF), which factorizes the ratingmatrices for multiple behaviors into the user and itemlatent factor space with group sparsity regularization.It can (1) select out the different subsets of latent factorsfor different behaviors, addressing that users’ decisionson different behaviors are determined by differentsets of factors;(2) model the dependence and independencebetween behaviors by learning the sharedand private factors for multiple behaviors automatically; (3) allow the shared factors between different behaviorsto be different, instead of all the behaviors sharingthe same set of factors. Experiments on the real-world dataset demonstrate that our model can integrate users’multiple types of behaviors into recommendation better,compared with other state-of-the-arts.
Anonymous voting by two-round public discussion

In 2006, Hao and Zielinski proposed a two-round anonymous veto protocol (called AV-net), which provided exceptional efficiency compared to related techniques. In this study, the authors add a self-tallying function to the AV-net, making it a general-purpose voting protocol. The new protocol works in the same setting as the AV-net – it requires no trusted third parties or private channels, and participants execute the protocol by sending two-round public messages. Compared with related voting protocols in past work, this is significantly more efficient in terms of the number of rounds, computational cost and bandwidth usage.
Subarachnoid Blood Causes Pial Arteriolar Constriction in Newborn Pigs

Background and Purpose The present study was designed to determine in newborn animals the delayed effect of subarachnoid blood on pial arteriolar diameter and eicosanoid concentrations in cortical periarachnoid fluid. Methods Forty-eight to 96 hours after subarachnoid blood installation, closed cranial windows were implanted over the cerebral area exposed to blood in anesthetized, artificially ventilated newborn piglets. All pial arterioles greater than 60 μm in diameter were measured, and cortical periarachnoid fluid was collected for the determination of eicosanoids. Results Subarachnoid blood resulted in a 20% to 30% decrease in the average diameter of pial arterioles exposed to blood for 48 to 96 hours, a decreased number of large pial arterioles (greater than 200 μm), and an increased number of small arterioles (60 to 100 μm). No changes in dilator prostanoids (prostacyclin [as 6-keto-prostaglandin F1α] and prostaglandin E2) were detected. Concentrations of vasoconstrictor prostanoids in cortical cerebrospinal fluid increased. Thromboxane B2 increased to 430 ± 70 pg/mL, and prostaglandin F2α increased to 1370 ± 180 pg/mL compared with 250 ± 20 and 860 ± 70 pg/mL, respectively, in the control group. The concentration of peptidoleukotrienes increased to 400 to 600 pg/mL 72 to 96 hours after blood installation, while the level in the control group was less than 80 pg/mL. Conclusions The altered balance between vasodilator and vasoconstrictor eicosanoids could contribute to cerebral vasoconstriction after subarachnoid blood installation in newborn pigs. (Stroke. 1993;24:1729-1734.)