Miracle-dz/UniFAR-FTUs huggingface dataset:
Consistent Pretesting for Jumps

If the intensity parameter in a jump diffusion model is identically zero, then parameters characterizing the jump size density cannot be identified. In general, this lack of identification precludes consistent estimation of identified parameters. Hence, it should be standard practice to consistently pretest for jumps, prior to estimating jump diffusions. Many currently available tests have power against the presence of jumps over a nite time span (typically a day or a week); and, as already noted by various authors, jumps may not be observed over nite time spans, even if the intensity parameter is strictly positive. Such tests cannot be consistent against non-zero intensity. Moreover, sequential application of nite time span tests usually leads to sequential testing bias, which in turn leads to jump discovery with probability one, in the limit, even if the true intensity is identically zero. This paper introduces tests for jump intensity, based on both in- ll and long-span asymptotics, which solve both the test consistency and the sequential testing bias problems discussed above, in turn facilitating consistent estimation of jump diffusion models. A self excitement test is also introduced, which is designed to have power against path dependent intensity, thus providing a direct test for the Hawkes diffusion model of Ait-Sahalia, Cacho-Diaz and Laeven (2013). In a series of Monte Carlo experiments, the proposed tests are evaluated, and are found to perform adequately in nite samples.
Bereavement and Companion Animals

Loss of a companion animal accompanied by intense grief and mourning is seldom recognized as an important and authentic occasion for bereavement. While pet ownership is praised and its virtues celebrated, corresponding grief is often trivialized and not recognized as truly significant. The author established a bereavement counseling program at a humane society and reports findings that confirm parallels between human and animal bonding and bereavements. The act of consenting to euthanasia was particularly disturbing, as if the owner had betrayed a trust by opting for death over life. Most of the bereaved owners reported depths of feeling that were unique and in most cases beyond those experienced in other deaths.
Roles of ramR and tet(A) Mutations in Conferring Tigecycline Resistance in Carbapenem-Resistant Klebsiella pneumoniae Clinical Isolates

ABSTRACT Tigecycline is regarded as a last-resort treatment for carbapenem-resistant Klebsiella pneumoniae (CRKP) infections, but increasing numbers of tigecycline-resistant K. pneumoniae isolates have been reported. The tigecycline resistance mechanisms in CRKP are undetermined. This study aimed to elucidate the mechanisms underlying tigecycline resistance in 16 tigecycline- and carbapenem-resistant K. pneumoniae (TCRKP) isolates. Mutations in tigecycline resistance determinant genes [ramR, acrR, oqxR, tet(A), tet(L), tet(X), tet(M), rpsJ] were assessed by PCR amplicon sequencing, and mutations in ramR and tet(A) exhibited high prevalences individually (81%) and in combination (63%). Eight functional ramR mutation profiles reducing tigecycline sensitivity were verified by plasmid complementation of wild-type and mutant ramR. Using a site-specific mutant, the most frequent RamR mutation, A19V (60%), had no significant effect on tigecycline susceptibility or the upregulation of ramA and acrA. Two tet(A) variants with double frameshift mutations, type 1 and type 2, were identified; type 2 tet(A) is novel. A parent strain transformed with a plasmid carrying type 1 or type 2 tet(A) increased the tigecycline MIC by 8-fold or 4-fold, respectively. Synergistic effects were observed in strains harboring no ramR gene and a mutated tet(A), with an 8-fold increase in the tigecycline MIC compared with that in strains harboring only mutated tet(A) being seen. Overall, mutations in the ramR and tet(A) efflux genes constituted the major tigecycline resistance mechanisms among the studied TCRKP isolates. The identification of strains exhibiting the combination of a ramR deficiency and widespread mutated tet(A) is concerning due to the possible dissemination of increased tigecycline resistance in K. pneumoniae.
Distinct expression profiles of Notch-1 protein in human solid tumors: Implications for development of targeted therapeutic monoclonal antibodies

Biological therapies, such as monoclonal antibodies (mAbs) that target tumor-associated antigens have been considered an effective therapeutic approach in oncology. In considering Notch-1 receptor as a potential target, we performed immunohistochemistry on tissue microarrays to determine 1) whether the receptor is overexpressed in tumor cells as compared to their corresponding normal tissues and 2) the clinical significance of its expression levels in human breast, colorectal, lung and prostate cancers. We found that the expression of Notch-1 protein was overexpressed in primary colorectal adenocarcinoma and nonsmall cell lung carcinoma (NSCLC), but not in primary ductal breast carcinoma or prostate adenocarcinoma. Further analysis revealed that higher levels of Notch-1 protein expression were significantly associated with poorer differentiation of breast and prostate tumors. Strikingly, for NSCLC, the expression levels of Notch-1 protein were found to be inversely correlated with tumor differentiation and progression. For colorectal tumors, however, no correlation of Notch-1 protein expression was found with any tumor clinicopathological parameters, in spite of its overexpression in tumor cells. Our data demonstrated the complexity of Notch-1 protein expression in human solid tumors and further supported the notion that the roles of Notch-1 expression in tumorigenesis are highly context-dependent. The findings could provide the basis for development of distinct therapeutic strategies of Notch-1 mAbs for its applications in the treatment of suitable types of human cancers.
CrisisLex: A Lexicon for Collecting and Filtering Microblogged Communications in Crises

Locating timely, useful information during crises and mass emergencies is critical for those forced to make potentially life-altering decisions. As the use of Twitter to broadcast useful information during such situations becomes more widespread, the problem of finding it becomes more difficult. We describe an approach toward improving the recall in the sampling of Twitter communications that can lead to greater situational awareness during crisis situations. First, we create a lexicon of crisis-related terms that frequently appear in relevant messages posted during different types of crisis situations. Next, we demonstrate how we use the lexicon to automatically identify new terms that describe a given crisis. Finally, we explain how to efficiently query Twitter to extract crisis-related messages during emergency events. In our experiments, using a crisis lexicon leads to substantial improvements in terms of recall when added to a set of crisis-specific keywords manually chosen by experts; it also helps to preserve the original distribution of message types.
Development of NG2 neural progenitor cells requires Olig gene function

In the adult central nervous system, two distinct populations of glial cells expressing the chondroitin sulfate proteoglycan NG2 have been described: bipolar progenitor cells and more differentiated “synantocytes. ” These cells have diverse neurological functions, including critical roles in synaptic transmission, repair, and regeneration. Despite their potential importance, the genetic factors that regulate NG2 cell development are poorly understood, and the relationship of synantocytes to the oligodendroglial lineage, in particular, remains controversial. Here, we show that >90% of embryonic and adult NG2 cells express Olig2, a basic helix–loop–helix transcription factor required for oligodendrocyte lineage specification. Analysis of mice lacking Olig function demonstrates a failure of NG2 cell development at embryonic and perinatal stages that can be rescued by addition of a transgene containing the human OLIG2 locus. These findings show a general requirement for Olig function in NG2 cell development and highlight further roles for Olig transcription factors in neural progenitor cells.
"Trust me, I know what I'm doing!" Competence Fields as a Means of Establishing Political Leadership

Competence fields are conceptualised as an alternative to the median-voter approach to the relationship between political leaders and constituencies. The notion of competence fields assumes that prospective political leaders need be regarded as competent in order to convince constituencies of their leadership abilities. It is argued that competence is a constructivist concept – political actors invoke claims of competence, backed by more or less strong, contextually dependent reasons in speech acts, by means of which they attempt to convince the audience of their leadership abilities. It is also argued that the construction of competence becomes particularly problematic in times of crisis, when pressures from the social context onto the prospective leaders make their claims of competence generally less convincing. Leaders are then expected to resort to all sorts of rhetorical devices and draw public attention to those competence fields in which minimal costs are to be incurred in order to establish themselves as competent in front of the constituencies. An example of an agent-based model of ethnicity as one such competence field is provided. It is argued that competence fields can be further investigated by a combination of traditional social-scientific methods and various methods and techniques from the fields of information retrieval and computer modelling, which can be particularly helpful in providing empirical evidence of competence fields.
Heterogeneous oxidation of saturated organic aerosols by hydroxyl radicals: Uptake kinetics and condensed-phase products

The kinetics and reaction mechanism for the heterogeneous oxidation of saturated organic aerosols by gas-phase OH radicals were investigated under NOx-free conditions. The reaction of 150 nm diameter Bis(2-ethylhexyl) sebacate (BES) particles with OH was studied as a proxy for chemical aging of atmospheric aerosols containing saturated organic matter. An aerosol reactor flow tube combined with an Aerodyne time-of-flight aerosol mass spectrometer (ToF-AMS) and scanning mobility particle sizer (SMPS) was used to study this system. Hydroxyl radicals were produced by 254 nm photolysis of O3 in the presence of water vapour. The kinetics of the heterogeneous oxidation of the BES particles was studied by monitoring the loss of a mass fragment of BES with the ToF-AMS as a function of OH exposure. We measured an initial OH uptake coefficient of ? 0 = 1.26 (±0.04), confirming that this reaction is highly efficient. The density of BES particles increased by up to 20% of the original BES particle density at the highest OH exposure studied, consistent with the particle becoming more oxidized. Electrospray ionization mass spectrometry analysis showed that the major particle-phase reaction products are multifunctional carbonyls and alcohols with higher molecular weights than the starting material. Volatilization of oxidation products accounted for a maximum of 17% decrease of the particle volume at the highest OH exposure studied. Tropospheric organic aerosols will become more oxidized from heterogeneous photochemical oxidation, which may affect not only their physical and chemical properties, but also their hygroscopicity and cloud nucleation activity.
Recursive structure and motion from image sequences using shape and depth spaces

A novel recursive method for estimating structure and motion from image sequences is presented. The novelty lies in the fact that the output of the algorithm is independent of the chosen coordinate systems in the images as well as the ordering of the points. It relies on subspace methods and is derived from both ordinary coordinate representations and camera matrices and from a so called depth and shape analysis. Furthermore, no initial phase is needed to start up the algorithm. It starts directly with the first two images and incorporates new images as soon as new corresponding points are obtained. The performance of the algorithm is shown on simulated data. Moreover, the two different approaches, one using camera matrices and the other using the concepts of affine shape and depth, are unified into a general theory of structure and motion from image sequences.
Executive function, mentalizing and humor in major depression

Major depression is associated with cognitive deficits including memory, executive functions, and affect perception, which have been linked to dysfunction of fronto-subcortical networks. However, little is known about social cognition on more complex socially relevant tasks, such as humor processing. In this investigation a computerized humor-processing task was administered to 27 patients with a diagnosis of major depression (Dep) and 27 healthy controls (HC). Theory of mind (mentalizing) and executive functions were also assessed. Both groups were similar in IQ, age, and gender. Depressed patients performed below the control group with respect to both affective and cognitive aspects of humor processing, and these were related to mentalizing and executive performance. Our findings suggest social cognition deficits in major depression. Ability to process humor and appreciate mentalistic perspectives may in turn influence social interactions and should be given consideration in therapeutic approaches to depression. (JINS, 2008, 14, 55–62.)
Prevention through parent training: Making more of a difference

Responding to serious behaviour problems requires new practice answers and emphases. Best practice principles and a developmental perspective indicate that the family should be the focus of preventative work. The Incredible Years parent training series is described as an important example of an empirically-supported programme that is presently being used in Tauranga and elsewhere in New Zealand. Impediments to prevention efforts are discussed and arguments are made regarding the relevance and significance of preventative strategies.
Modeling of Molecular Interaction between Apoptin, BCR-Abl and CrkL - An Alternative Approach to Conventional Rational Drug Design

In this study we have calculated a 3D structure of apoptin and through modeling and docking approaches, we show its interaction with Bcr-Abl oncoprotein and its downstream signaling components, following which we confirm some of the newly-found interactions by biochemical methods. Bcr-Abl oncoprotein is aberrantly expressed in chronic myelogenous leukaemia (CML). It has several distinct functional domains in addition to the Abl kinase domain. The SH3 and SH2 domains cooperatively play important roles in autoinhibiting its kinase activity. Adapter molecules such as Grb2 and CrkL interact with proline-rich region and activate multiple Bcr-Abl downstream signaling pathways that contribute to growth and survival. Therefore, the oncogenic effect of Bcr-Abl could be inhibited by the interaction of small molecules with these domains. Apoptin is a viral protein with well-documented cancer-selective cytotoxicity. Apoptin attributes such as SH2-like sequence similarity with CrkL SH2 domain, unique SH3 domain binding sequence, presence of proline-rich segments, and its nuclear affinity render the molecule capable of interaction with Bcr-Abl. Despite almost two decades of research, the mode of apoptin's action remains elusive because 3D structure of apoptin is unavailable. We performed in silico three-dimensional modeling of apoptin, molecular docking experiments between apoptin model and the known structure of Bcr-Abl, and the 3D structures of SH2 domains of CrkL and Bcr-Abl. We also biochemically validated some of the interactions that were first predicted in silico. This structure-property relationship of apoptin may help in unlocking its cancer-selective toxic properties. Moreover, such models will guide us in developing of a new class of potent apoptin-like molecules with greater selectivity and potency.
Beyond ‘dusty archives’: The economic benefits of preserving recorded heritage

Abstract Libraries and archives are increasingly under pressure to justify the cost of preserving the recorded heritage. This paper addresses the real need to identify and measure the benefits of preservation of the recorded heritage in the UK. Stated preference techniques are well established in the field of environmental economics, and they are also appropriate for the valuation of cultural heritage. The authors develop and test a methodology to estimate people's preferences for the preservation of the recorded heritage through two stated preference case (pilot) studies. All library and archive materials supporting the written and documentary heritage of the chosen case studies have been considered. The benefits of preservation are identified as those associated with the use of the recorded heritage (for example, by schools, commercial organisations, academics and other interested parties), the option of using it in the future, and the value placed on its existence by the general public, even if they have no intention of using it. The main advantage of estimating the benefits of preservation in monetary terms is that these can be compared with the costs of preservation to determine whether any given project or policy is worthwhile, or indeed to choose among competing projects for the allocation of funds.
Reduced-Memory Decoding of Low-Density Lattice Codes

This letter describes a belief-propagation decoder for low-density lattice codes of finite dimension, in which the messages are represented as single Gaussian functions. Compared to previously-proposed decoders, memory is reduced because each message consists of only two values, the mean and variance. Complexity is also reduced because the check node operations are on single Gaussians, avoiding approximations needed previously, and because the variable node performs approximations on a smaller number of Gaussians. For lattice dimension n = 1000 and 10,000, this decoder looses no more than 0.1 dB in SNR, compared to the decoders which use much more memory.
Packing bag-of-features

One of the main limitations of image search based on bag-of-features is the memory usage per image. Only a few million images can be handled on a single machine in reasonable response time. In this paper, we first evaluate how the memory usage is reduced by using lossless index compression. We then propose an approximate representation of bag-of-features obtained by projecting the corresponding histogram onto a set of pre-defined sparse projection functions, producing several image descriptors. Coupled with a proper indexing structure, an image is represented by a few hundred bytes. A distance expectation criterion is then used to rank the images. Our method is at least one order of magnitude faster than standard bag-of-features while providing excellent search quality.
Childhood Risk Factors for Women's Sexual Victimization

The purpose of this study was to examine a broad range of childhood experiences associated with risk for sexual assault victimization in adulthood. Childhood experiences hypothesized to enhance vulnerability for adult sexual victimization, including maltreatment experiences perpetrated by adults and children as well as family composition variables, were examined. A community sample of 277 women attending outpatient clinics at an urban hospital provided retrospective self-report regarding family composition and cohesion, childhood maltreatment experiences perpetrated by adults and peers, and adulthood victimization. Results of logistic regression analysis indicate that early sexual experiences with peers, childhood sexual abuse by adults, father or father figure's absence as a primary caregiver in childhood, perceived level of closeness to father in adolescence, and neglect by mother pose significant risk for subsequent adult victimization
Osteoarthritis, magnetic resonance imaging, and biochemical markers: a one year prospective study

Objective: To investigate the relation between biochemical markers of bone, cartilage, and synovial remodelling and the structural progression of knee osteoarthritis. Methods: 62 patients of both sexes with knee osteoarthritis were followed prospectively for one year. From magnetic resonance imaging (MRI), done at baseline and after one year, the volume and thickness of cartilage of the femur, the medial tibia, and the lateral tibia were assessed. A whole organ magnetic resonance imaging score (WORMS) of the knee was calculated for each patient at baseline and at the one year visits. This score consists in a validated, semiquantitative scoring system for whole organ assessment of the knee in osteoarthritis using MRI. Biochemical markers (serum hyaluronic acid, osteocalcin, cartilage glycoprotein 39 (YKL-40), cartilage oligomeric matrix protein (COMP), and C-telopeptide of type I collagen (CTX-I), and urine C-telopeptide of type II collagen (CTX-II)) were measured at baseline and after three months. Results: Baseline markers were not correlated with one year changes observed in cartilage volume and thickness. However, an increase in CTX-II after three months was significantly correlated with a one year decrease in mean thickness of medial tibial and lateral tibial cartilage. Patients in the highest quartile of three month changes in CTX-II experienced a mean loss of 0.07 (0.08) mm of their medial thickness, compared with a mean increase of 0.05 (0.19) mm for patients in the lowest quartile (p = 0.04) Multiple regression analysis showed that high baseline levels of hyaluronic acid are predictive of a worsening in WORMS (p = 0.004). Conclusions: These results suggest that a single measurement of serum hyaluronic acid or short term changes in urine CTX-II could identify patients at greatest risk of progression of osteoarthritis.
In Kidney Transplant Recipients With a Positive Virtual Crossmatch, High PRA was Associated With Lower Incidence of Viral Infections

Background There is little information on the incidence, risk factors, and outcomes associated with CMV and BK infections in sensitized patients. Methods We examined 254 consecutive kidney transplant recipients with positive virtual crossmatch and negative flow crossmatch. Results A total of 111 patients (43%) developed CMV disease or BK infection or nephropathy (BKVN). Specifically, 78 patients (30.7%) developed BK infection, 19 (7.5%) had BKVN, and 33 (12.9%) presented with CMV disease. Four patients (1.5%) developed both infections. Mean time from transplant to diagnosis for BK and CMV was 4.07 ± 3.10 and 8.35 ± 5.20 months, respectively. African American (HR, 2.64; 95% CI, 1.37-5.07; P = 0.003), thymoglobulin induction (HR, 2.18; 95% CI, 1.38-3.43; P = 0.0008), DSA greater than 500 MFI at transplant (HR, 1.64; 95% CI, 1.05-2.57; P = 0.03), history of diabetes (HR, 1.62; 95% CI, 1.01-2.60; P = 0.04), CMV D+/R- (HR, 2.30; 95% CI, 1.06-5.01; P = 0.03), and acute rejection (HR, 1.49; 95% CI, 0.99-2.24; P = 0.05) were associated with increase incident of BK/CMV, whereas rituximab (HR, 0.47; 95% CI, 0.24-0.91; P = 0.02), peak PRA greater than 80% (HR, 0.48; 95% CI, 0.27-0.84; P = 0.01), and living donor transplant (HR, 0.57; 95% CI, 0.36-0.87; P = 0.01) were associated with a lower likelihood of infection. Thymoglobulin induction (HR, 2.50; 95% CI, 1.02-6.13; P = 0.04), and peak PRA greater than 80% (HR, 0.45; 95% CI, 0.23-0.86; P = 0.02) remained significant predictors of infection after multivariate adjustment. Conclusions Although more than 40% of patients with a positive virtual crossmatch presented with BK infection/CMV disease, high PRA greater than 80% seemed to be protective.