Miracle-dz/UniFAR-FTUs huggingface dataset:
Improved quantization error characteristics in FIR differentiators using irregular sampling

It is shown that irregular sampling can be used to advantage in FIR differentiators for quantized systems, by reducing the maximum error caused by input quantization. Formulae are derived for 1) the filter coefficients that correspond to minimum average mean-squared output error, given white noise at the input; and 2) the mean-squared error of the quantized system in the important constant-rate case. Comparisons between system performance for regular and irregular sampling are presented for one simple sampling strategy. The differentiators have been used to advantage as velocity estimators in motion control systems, but have wider application.
Trace element levels in adult patients with proteinuria.

AIM Trace elements are involved in many metabolic processes. They circulate prevalently bound to protein. In literature few studies deal with metal metabolism in adult patients with proteinuria, so we decided to further investigate metal metabolism in proteinuric patients. METHODS We studied 27 patients (14 male, 13 female), mean age 61.6+/-17 years with different degrees of renal function, serum albumin and proteinuria. Metal concentrations of copper (Cu), zinc (Zn) and aluminum (Al) were measured in serum and urine. No patient had environmental exposure to these metals. RESULTS The serum Zn level was below the normal range in 11 patients. The serum Cu level was reduced in 5 patients. The Al serum level was elevated in 4 patients. Six patients had reduced and 6 patients had elevated Zn excretion. The urinary Cu excretion was elevated in 6 patients. The urinary Al excretion was elevated in 1 patient. Trace metal concentrations were related neither to renal function nor to total serum protein or albumin levels. Serum zinc was directly correlated with proteinuria and urinary zinc and negatively correlated with testosterone levels in both sexes. CONCLUSION Adult patients with proteinuria have several modification of trace metal concentration in serum and urine. Serum concentration of metals did not depend on renal function or serum protein levels. Urinary Zn excretion was directly related to proteinuria and serum Zn levels. A negative correlation between serum Zn levels and testosterone was found in both sexes. Renal failure reduced urinary excretion of Cu and Al.
Maximum Entropy Correlated Equilibria

We study maximum entropy correlated equilibria (Maxent CE) in multi-player games. After motivating and deriving some interesting important properties of Maxent CE, we provide two gradient-based algorithms that are guaranteed to converge to it. The proposed algorithms have strong connections to algorithms for statistical estimation (e.g., iterative scaling), and permit a distributed learning-dynamics interpretation. We also briefly discuss possible connections of this work, and more generally of the Maximum Entropy Principle in statistics, to the work on learning in games and the problem of equilibrium selection.
A Quick Verication of the 2-D Galaxy Distribution with SDSS Data

We present source code for the computer algebra system Mathematica that analyzes the distribution of nearby Galaxies using SDSS data. Download instructions are given, thus within 10 minutes, the reader can verify that galaxies are distributed in an essentially non-homogeneous manner and cluster on 2-dimensional structures. The short code uses a simple method inspired by Minkowski functionals: the distances to the next neighbors are calculated and compared to random distributions in three and two dimensions. The observed distance distribution corresponds clearly to the latter case. The paper may also be helpful for nonexpert scientists to get started with SDSS data analysis.
Monomeric, Oligomeric and Polymeric Proteins in Huntington Disease and Other Diseases of Polyglutamine Expansion

Huntington disease and other diseases of polyglutamine expansion are each caused by a different protein bearing an excessively long polyglutamine sequence and are associated with neuronal death. Although these diseases affect largely different brain regions, they all share a number of characteristics, and, therefore, are likely to possess a common mechanism. In all of the diseases, the causative protein is proteolyzed, becomes abnormally folded and accumulates in oligomers and larger aggregates. The aggregated and possibly the monomeric expanded polyglutamine are likely to play a critical role in the pathogenesis and there is increasing evidence that the secondary structure of the protein influences its toxicity. We describe here, with special attention to huntingtin, the mechanisms of polyglutamine aggregation and the modulation of aggregation by the sequences flanking the polyglutamine. We give a comprehensive picture of the characteristics of monomeric and aggregated polyglutamine, including morphology, composition, seeding ability, secondary structure, and toxicity. The structural heterogeneity of aggregated polyglutamine may explain why polyglutamine-containing aggregates could paradoxically be either toxic or neuroprotective.
Comparative studies on the structure and development of the venom‐delivery system of centipedes, and a hypothesis on the origin of this evolutionary novelty

The venom‐injecting forcipules of centipedes represent an evolutionary novelty that appeared in the centipede stem lineage more than 400 Ma. No other lineage of arthropods (or indeed of animals) has evolved claws for injecting venom from a pair of walking legs. However, little is known of the development, ultrastructure, or detailed function of centipede forcipules. Here, we provide comparative structural information on the venom duct apparatus that is the main functional system within each forcipule, based on scanning electron microscopy and transmission electron microscopy studies. We also give comparative developmental information, using DAPI staining, on embryonic forcipules from the four main centipede orders, including Scutigeromorpha. The photographs of Scutigera embryos we present are the first to be published for any species belonging to this order. The structure of the venom apparatus within each forcipule represents a discrete element of the novelty, whose origin requires a special explanation. This is in contrast to the novel external shape of the forcipules, which can be arrived at gradually by a series of changes from the starting point of a standard walking leg. Drawing on a proposed structural homology between venom glands and epidermal glands, we present a hypothesis of how the venom gland and duct may have arisen in evolution.
Mimicry of the Regulatory Role of Urokinase in Lamellipodia Formation by Introduction of a Non-native Interdomain Disulfide Bond in Its Receptor*

Background: The urokinase receptor (uPAR) acts as a modulator of lamellipodia formation on vitronectin-rich matrices. Results: Constraining the flexibility of uPAR by an interdomain cross-link drives it into a constitutively active state. Conclusion: Conformational dynamics of uPAR is important for its function and is regulated by uPA binding. Significance: This flexibility needs to be considered when investigating and targeting the function of uPAR. The high-affinity interaction between the urokinase-type plasminogen activator (uPA) and its glycolipid-anchored receptor (uPAR) plays a regulatory role for both extravascular fibrinolysis and uPAR-mediated adhesion and migration on vitronectin-coated surfaces. We have recently proposed that the adhesive function of uPAR is allosterically regulated via a “tightening” of its three-domain structure elicited by uPA binding. To challenge this proposition, we redesigned the uPAR structure to limit its inherent conformational flexibility by covalently tethering domains DI and DIII via a non-natural interdomain disulfide bond (uPARH47C-N259C). The corresponding soluble receptor has 1) a smaller hydrodynamic volume, 2) a higher content of secondary structure, and 3) unaltered binding kinetics towards uPA. Most importantly, the purified uPARH47C-N259C also displays a gain in affinity for the somatomedin B domain of vitronectin compared with uPARwt, thus recapitulating the improved affinity that accompanies uPA-uPARwt complex formation. This functional mimicry is, intriguingly, operational also in a cellular setting, where it controls lamellipodia formation in uPAR-transfected HEK293 cells adhering to vitronectin. In this respect, the engineered constraint in uPARH47C-N259C thus bypasses the regulatory role of uPA binding, resulting in a constitutively active uPAR. In conclusion, our data argue for a biological relevance of the interdomain dynamics of the glycolipid-anchored uPAR on the cell surface.
Influence of Paclobutrazol on Shoot Growth and Flowering in a High-density Pecan Orchard

Paclobutrazol (PBZ) was applied to 6-year-old pecan (Carya illinoinensis) trees as a basal trunk drench (0, 30, 90, and 150 mg·cm−2 trunk cross-sectional area) in Dec. 2012. Terminal shoot growth was retarded for 1 year after a single application of PBZ. The total number of current season shoots showed a significant increase with 30- and 90-mg·cm−2 PBZ treatments. After PBZ application at 30, 60, and 90 mg·cm−2, the percentage of very short shoots (<5 cm) was 32.3%, 36.3%, and 32.3%, respectively, compared with 22.4% on control trees; the percentage of short shoots (5–15 cm) increased to 36.0%, 38.1%, and 43.5%, respectively. The percent of long shoots (>30 cm) was decreased to 7.4%, 5.1%, and 7.6%, respectively, after PBZ application, compared with 18.7% with control. Shoots varying from 5 to 30 cm in length accounted for at least 63.3% of all pistillate inflorescences the following spring.
Nutrient profile of five freshwater fish species

The nutrient profile of five freshwater fish species viz., Mystus vittatus, Ompok bimaculatus, Channa striata, Wallago attu and Pangasianodon hypophthalmus were studied. The proximate composition data shows that the moisture and fat content differed significantly (P<0.01) among the fish species. The fat content was significantly higher in P. hypophthalmus and M. vittatus. The moisture was significantly higher in C. striata. The potassium content was significantly (p<0.01) higher in C.striata. M.vittatus shows higher content of calcium. The other trace minerals like iron, copper and zinc contents of fish did not differ significantly among the species. The vitamin A content is maximum in O.bimaculatus whereas vitamin D content is higher in Mystus vittatus. The palmitic acid was significantly (p<0.01) higher in M. vittatus. The oleic acid was significantly (p<0.01) higher in C. striata and W. attu. The linoleic acid content was significantly (p<0.05) higher in P. hypophthalmus. One of the important PUFA i.e. DHA was significantly higher in O. bimaculatus and C.striata. The PUFA content was significantly (p<0.05) higher in O.bimaculatus and P.hypophthalmus. Among the amino acids, arginine, histidine, threonine and isoleucine were higher in P.hypophthalmus. C.striata and W. attu contain high amount of Tryptophan. Glutamic acid was high in O.bimaculatus and Aspartic acid was high in C. striata. The energy content was maximum in P. hypophthalmus. The nutrient profile of these fish species revealed that they were rich in all the essential nutrients required by human being. The information on nutrient profile of fish will give a guideline to dieticians, nutritionists, medical practitioners, researchers to advice consumers to take fish in their daily diet as a health food. SAARC J. Agri. , 16(2): 25-41 (2018)
In Vitro Activities of Anidulafungin against More than 2,500 Clinical Isolates of Candida spp., Including 315 Isolates Resistant to Fluconazole

ABSTRACT Anidulafungin is an echinocandin antifungal agent with potent activity against Candida spp. We assessed the in vitro activity of anidulafungin against 2,235 clinical isolates of Candida spp. using the CLSI broth microdilution method. Anidulafungin was very active against Candida spp. (the MIC at which 90% of strains are inhibited [MIC90] was 2 μg/ml when MIC endpoint criteria of partial inhibition [MIC-2] were used). Candida albicans, C. glabrata, C. tropicalis, C. krusei, and C. kefyr were the most susceptible species of Candida (MIC90, 0.06 to 0.12 μg/ml), and C. parapsilosis, C. lusitaniae, and C. guilliermondii were the least susceptible (MIC90, 0.5 to 2 μg/ml). In addition, 315 fluconazole-resistant isolates were tested, and 99% were inhibited by ≤1 μg/ml of anidulafungin. These results provide further evidence for the spectrum and potency of anidulafungin activity against a large and geographically diverse collection of clinically important isolates of Candida spp.
Carrier Synchronization of Offset Quadrature Phase-Shift Keying

This article contains analyses of the performance of various carrier synchronization loops for ofiset quadrature phase-shift-keying (OQPSK) modulation, all motivated in one form or another by the maximum a posteriori (MAP) estimation of carrier phase. When they are implemented as either high or low signal-to-noise ratio (SNR) approximations to the generic implementation suggested by the MAP estimation of carrier phase for an OQPSK signal, it is shown that the loops behave more like biphase than quadriphase loops in that they only exhibit a 180-deg phase ambiguity rather than the 90-deg phase ambiguity typical of the latter. This phase ambiguity advantage coupled with the mean-square tracking-error performance advantage that results and its ultimate efiect on average error probability performance ofier a potentially signiflcant justiflcation for using OQPSK rather than QPSK even on a linear transmission channel, where it often is reasoned (based on the assumption of an ideal environment) that the two modulation schemes perform identically.
Atypical morphological characteristics and surface antigen expression of Burkholderia pseudomallei in naturally infected human synovial tissues

Burkholderia pseudomallei is the causative agent of melioidosis, a disease that frequently runs a protracted course and is very difficult to eradicate. The mechanisms that this organism uses to escape from host defense mechanisms and antibiotics are not well understood. The aim of the study was to compare the morphological characteristics and surface antigen expression of B. pseudomallei in naturally infected human synovial tissues with the characteristics of bacteria grown in culture media. Immunoelectron microscopic study was performed in four synovial biopsies taken from four B. pseudomallei septic arthritis patients. Colonies of pathogenic B. pseudomallei collected from culture media were used as positive controls. Polyclonal antibody to whole cell B. pseudomallei was used as a primary antibody. Complete bacteria-like particles were demonstrated both extracellularly and intracellularly in all four synovial specimens. The intracytoplasmic location of B. pseudomallei and mononuclear phagosome containing microcolony-like structures were demonstrated. B. pseudomallei found in the synovial membrane samples were mostly atypical, with fewer cytoplasmic electron lucent granules. Immunogold staining of bacterial surface antigens was weaker than staining of positive controls. We demonstrated atypical forms of B. pseudomallei and evidence for suppression of its surface antigens in naturally infected human synovial tissues. This adaptation may help bacteria to survive despite host immune surveillance and treatment with antibiotics.
Mouse Cristin/R-spondin Family Proteins Are Novel Ligands for the Frizzled 8 and LRP6 Receptors and Activate β-Catenin-dependent Gene Expression*

Wnt signaling plays critical biological roles during normal embryonic development and homeostasis in adults. In the canonical pathway, binding of Wnt ligands to the Frizzled (Fzd) receptor and the low density lipoprotein-related receptor (LRP) 5 or LRP6 coreceptor initiates downstream signaling events leading to gene activation by β-catenin and the T-cell factor (TCF)-lymphoid enhancer factor (LEF) family transcription factor complex. In this study, we provide several lines of evidence that the mouse Cristin/R-spondin family proteins function as Fzd8 and LRP6 receptor ligands and induce the canonical Wnt/β-catenin signaling pathway, leading to TCF-dependent gene activation. First, conditioned medium containing Cristin/R-spondin proteins effectively induced reporter activity in a TCF-binding site-dependent manner. Second, stimulation of cells with Cristin/R-spondin was accompanied by stabilization of endogenous β-catenin proteins and induction of canonical Wnt target genes. Third, Cristin/R-spondin proteins physically interacted with the extracellular domains of the LRP6 and Fzd8 receptors in vivo and in vitro. Interestingly, unlike canonical Wnt ligands, Cristin/R-spondin failed to form a ternary complex with both LRP6 and Fzd8 receptors, suggesting that R-spondin may activate the canonical Wnt signaling pathway by different mechanisms. Furthermore, Cristin/R-spondin proteins possess an intriguing positive modulatory activity on Wnt ligands, possibly through a direct interaction. Our findings expand the repertoire of ligands that induce β-catenin/TCF-dependent gene activation and implicate the presence of active β-catenin-dependent gene activation in a Wnt-free biological context.
Distance to screening site and older adults’ participation in cognitive impairment screening

To develop intervention strategies that promote screening for cognitive impairment, it is essential to identify the modifiable predictors for participation in screening. The present study aimed to examine whether a shorter distance to the screening site predicted participation in screening for cognitive impairment, and whether interactive effects of the distance and psychological factors on the participation would be observed among community‐dwelling older adults.
Contribution of the technique of thermostimulated currents for the elucidation of the nature of the Johari-Goldstein and other secondary relaxations in the vitreous state

In this work the usefulness of the technique of thermally stimulated depolarization currents (TSDC) to the study of the secondary relaxations in amorphous solids, and particularly of the Johari-Goldstein (JG) relaxation, is emphasized. The features of the JG relaxation are carefully analyzed, and the contribution of this experimental technique for the elucidation of its molecular mechanisms is also stressed.
Critical Index of Difficulty for Different Body Motions: A Review

ABSTRACT K. -C. Gan and E. R. Hoffmann (1988) demonstrated that there is a clear boundary between values of Fitts' index of difficulty (ID) below which movements may be made without ongoing path corrections; above this value it was necessary to use corrections to hit a target of high ID. It is shown that this critical ID (IDcrit) value is dependent on both the body component making the movement and on the form of feedback available to the person. The arm system, having the highest ratio of muscle strength to mass moment of inertia, has the highest value of IDcrit, whereas control of the body center of mass location has the lowest value of IDcrit. It is suggested that the use of visual control to lower ID values with the larger body components is due to the longer movement times available because of the physical characteristics of these components—the time is available, and therefore it is used to make path corrections.
A Non-Coding RNA Within the Rasgrf1 Locus in Mouse Is Imprinted and Regulated by Its Homologous Chromosome in Trans

Background Rasgrf1 is imprinted in mouse, displaying paternal allele specific expression in neonatal brain. Paternal expression is accompanied by paternal-specific DNA methylation at a differentially methylated domain (DMD) within the locus. The cis-acting elements necessary for Rasgrf1 imprinting are known. A series of tandem DNA repeats control methylation of the adjacent DMD, which is a methylation sensitive enhancer-blocking element. These two sequences constitute a binary switch that controls imprinting and represents the Imprinting Control Region (ICR). One paternally transmitted mutation, which helped define the ICR, induced paramutation, in trans, on the maternal allele. Like many imprinted genes, Rasgrf1 lies within an imprinted cluster. One of four noncoding transcripts in the cluster, AK015891, is known to be imprinted. Methodology/Principal Findings Here we demonstrate that an additional noncoding RNA, AK029869, is imprinted and paternally expressed in brain throughout development. Intriguingly, any of several maternally inherited ICR mutations affected expression of the paternal AK029869 transcript in trans. Furthermore, we found that the ICR mutations exert different trans effects on AK029869 at different developmental times. Conclusions/Significance Few trans effects have been defined in mammals and, those that exist, do not show the great variation seen at the Rasgrf1 imprinted domain, either in terms of the large number of mutations that produce the effects or the range of phenotypes that emerge when they are seen. These results suggest that trans regulation of gene expression may be more common than originally appreciated and that where trans regulation occurs it can change dynamically during development.
Termination of the geniculocortical projection in the striate cortex of macaque monkey: A quantitative immunoelectron microscopic study

The goal of this present study was to derive a new estimate of the synaptic contribution of the dorsal lateral geniculate nucleus (dLGN) to the subdivisions of its main recipient layer, layer 4C, of striate cortex of macaque monkey. The projection from the dLGN and its terminal boutons within layer 4C were visualized by immunodetection of the calcium binding protein, parvalbumin (PV), which is expressed in relay cells of the dLGN. The proportion of asymmetric synapses formed by PV‐positive boutons within the α and β sublayers of 4C was estimated by using a nonbiased stereological counting method. The proportion of asymmetric synapses contributed by the PV‐positive boutons to layer 4Cα is 8.7%; to 4Cβ is 6.9%. Assuming all the PV‐positive asymmetric synapses derive from the dLGN relay cells, this gives a ratio of dLGN synapses per neuron of 192 in layer 4Cα and 128 in layer 4Cβ. Thus, the recurrent excitatory input from neighboring cortical neurons must play an important part in responses of the neurons lying at the input stage of the cortical circuit. J. Comp. Neurol. 419:306–319, 2000. © 2000 Wiley‐Liss, Inc.