Miracle-dz/UniFAR-FTUs huggingface dataset:
Decreased L‐selectin expression in CD34‐positive cells from patients with chronic myelocytic leukaemia

Abnormal adhesive interaction between bone marrow stroma and progenitors, one of the causes of unregulated proliferation in chronic myelocytic leukaemia (CML), may be caused by some alterations in adhesion molecules on CML progenitors. We investigated the expression of adhesion molecules (CD44, VLA‐5, VLA‐4, LFA‐1, ICAM‐1, L‐selectin and c‐kit) on bone marrow CD34++ cells from 16 CML patients by three‐colour flow cytometry. The mean percentage of cells expressing L‐selectin in the CD34++CD38+ ∼ ++ fraction from untreated CML patients was significantly lower, and that in the CD34++CD38− fraction tended to be lower than that from normal controls. Among 11 CML patients treated with interferon‐α (IFN‐α), the mean percentage of the cells expressing L‐selectin in the CD34++CD38− fraction from three patients with a low percentage of Ph1(+) cells in bone marrow was significantly higher than that from five patients with a high percentage of Ph1(+) cells. In addition, L‐selectin expression rate was inversely correlated to the percentage of Ph1(+) cells. There was no significant difference between the untreated patients and normal controls with regard to the expression rates of the other adhesion molecules in each CD34++ fraction except LFA‐1. These data suggest that decreased L‐selectin expression in CML CD34++ cells reflects one of the features of malignant CML progenitors.
OpenSurfaces

The appearance of surfaces in real-world scenes is determined by the materials, textures, and context in which the surfaces appear. However, the datasets we have for visualizing and modeling rich surface appearance in context, in applications such as home remodeling, are quite limited. To help address this need, we present OpenSurfaces, a rich, labeled database consisting of thousands of examples of surfaces segmented from consumer photographs of interiors, and annotated with material parameters (reflectance, material names), texture information (surface normals, rectified textures), and contextual information (scene category, and object names). Retrieving usable surface information from uncalibrated Internet photo collections is challenging. We use human annotations and present a new methodology for segmenting and annotating materials in Internet photo collections suitable for crowdsourcing (e.g., through Amazon's Mechanical Turk). Because of the noise and variability inherent in Internet photos and novice annotators, designing this annotation engine was a key challenge; we present a multi-stage set of annotation tasks with quality checks and validation. We demonstrate the use of this database in proof-of-concept applications including surface retexturing and material and image browsing, and discuss future uses. OpenSurfaces is a public resource available at http://opensurfaces.cs. cornell.edu/.
Effects of multiple sclerosis on female sexuality: a controlled study.

AIM The aim of this study was to investigate the effects of multiple sclerosis (MS) on female sexuality. METHODS Present study included 142 females (70 MS patients, 72 healthy controls). MS patients were evaluated by Expanded Disability Status Scale (EDSS) for functional status, by Beck Depression Inventory (BDI) for severity of depression, by Visual Analog Scale (VAS) for severity of pain, and by Female Sexual Function Inventory (FSFI) for sexual function. MAIN OUTCOME MEASURES FSFI, BDI, EDSS, and VAS were the main outcome measures. RESULTS The number of weekly sexual intercourse, total FSFI, and FSFI subscale scores were lower in MS women compared with controls. FSFI total and FSFI subscale scores were statistically significantly lower in MS women with BDI score ≥ 17 compared with those with BDI score <17. A negative correlation was found between total FSFI score and BDI, EDSS, VAS, age, and duration of complaint, but a positive correlation was found with education level in MS women. CONCLUSIONS Sexual functions are negatively affected in MS women. Sexual functions in MS women seem to be associated with enhanced disability, pain, duration of the disease, and degree of concomitant depression. Therefore, women with MS should also be evaluated in terms of sexual function during routine follow-ups.
Prevalence of Escherichia coli O157 in Saskatchewan Cattle: Characterization of Isolates by Using Random Amplified Polymorphic DNA PCR, Antibiotic Resistance Profiles, and Pathogenicity Determinants

ABSTRACT The prevalence of Escherichia coli O157 associated with feedlot cattle in Saskatchewan was determined in a 10-month longitudinal study (3 feedlots) and a point prevalence study (20 feedlots). The prevalence of E. coli O157 at the three different sites in the horizontal study varied from 2.5 to 45%. The point prevalence of E. coli O157 among Saskatchewan cattle from 20 different feedlots ranged from 0% to a high of 57%. A statistically significant (P = 0.003) positive correlation was determined to exist between the density of cattle and the E. coli O157 prevalence rate. A significant correlation (P = 0.006) was also found between the E. coli O157 percent prevalence and the number of cattle housed/capacity ratio. All 194 E. coli O157 isolates obtained were highly virulent, and random amplified polymorphic DNA PCR analysis revealed that the isolates grouped into 39 different E. coli O157 subtypes, most of which were indigenous to specific feedlots. Two of the most predominant subtypes were detected in 11 different feedlots and formed distinct clusters in two geographic regions in the province. Antimicrobial susceptibility testing of the E. coli O157 isolates revealed that 10 were multidrug resistant and that 73 and 5 were resistant to sulfisoxazole and tetracycline, respectively.
Safety and efficacy of bioabsorbable magnesium alloy stents in porcine coronary arteries

Objective: We aimed to determine the safety and efficacy of biobasorbable magnesium alloy stents in porcine coronary arteries. Bioabsorbable magnesium stents carry the potential to overcome the limitations posed by permanent metallic stents such as chronic inflammation, late stent thrombosis, prolonged antiplatelet therapy, and artifacts when imaged by multislice‐computed tomography or magnetic resonance imaging. Methods: Magnesium alloy stents or stainless steel stents were randomly deployed in coronary arteries of domestic or minipigs. Domestic pigs were sacrificed at 3 days (n = 2) or 28 days, and minipigs at 3 months. Results: At 3 days, magnesium alloy stents were intact, but started to show signs of degradation by 28 days. There was no evidence of stent particle embolization, thrombosis, excess inflammation, or fibrin deposition. At 28 days and 3 months, neointimal area was significantly less in magnesium alloy stent segments (2.44 ± 0.88 mm2 and 1.16 ± 0.19 mm2) as compared with the stainless steel stent segments (5.03 ± 1.5 mm2 and 1.72 ± 0.68 mm2, P < 0.001 and 0.02). Quantitative coronary analysis indicates that percentage area stenosis and percentage diameter stenosis in magnesium alloy stent segments improved significantly at 3 months as compared to 28 days. Despite decreased neointimal hyperplasia, lumen area of the magnesium alloy stented vessels did not improve significantly. Conclusion: Magnesium alloy stents are safe and are associated with less neointima formation; however, reduced neointima did not result in larger lumen. © 2006 Wiley‐Liss. , Inc.
Corn, Klansmen, and Coolidge: Structure and Framing in Social Movements

This article examines how structural conditions and social movement frames interact to influence mobilization and political consequences of social movements. Mobilization efforts benefit when movement framing is congruent with local structural conditions. This mobilization, in turn, produces political leverage for the movement through its capacity to deliver support of its members and adherents. Its political advantage may be offset, however, if another of its key framing activities, the construction of collective identity boundaries, alienates the broader population and stimulates a backlash. Such backlash is also intimately connected to structural conditions because its potential is a function of the characteristics of the local population — specifically, the proportion of the population alienated by the movement's boundary construction. We apply these arguments to the case of the Indiana Ku Klux Klan in the 1920s and show that while the Klan's diagnostic and prognostic framing may have resonated structurally and facilitated the Klan's mobilization efforts, its exclusionary boundaries frustrated its attempts to secure broader political gains.
Parallel Heap Operations on an EREW PRAM

We consider parallel heap operations on the exclusive-read exclusive-write parallel random-access machine. We first present an O(n/p + log p) time parallel algorithm to construct a heap of n elements using p processors, which is optimal for p ? (n/log n). We then propose a parallel root deletion algorithm. In a preparatory step, a data structure for dynamic processor allocation is constructed using O((n/log n)1 ? 1/k) processors in O(log k) time for some constant k, 1 ? k ? log(n/log n)? A sequence of root deletions can then be performed, each of which takes O((log n)/p + log p + log log n) time using p processors. Finally, we discuss a parallel algorithm running in O((log n)/p + log p) time for inserting an element into a heap, which is optimal for p = ? ((log n)/log log n). Both deletion and insertion algorithms run in O(log log n) time when p = ? ((log n)/log log n).
Reminders of behavioral disinhibition increase public conformity in the Asch paradigm and behavioral affiliation with ingroup members

This paper argues that being in the Asch situation, where there is a felt need to conform to others’ faulty behaviors, poses a social threat to people. Furthermore, participating in a psychology experiment in which you will have to interact with other participants might trigger sense-making processes. The paper proposes that these assumed threats or sense-making processes are likely to activate the behavioral inhibition system, making people respond in more inhibited ways than they normally would be inclined to do. As a result, people’s tendency to affiliate behaviorally with persons who are similar to them can be inhibited. The implication is that lowering behavioral inhibition (by experimentally reminding people about having acted without behavioral inhibitions) should lead to more public conformity in the Asch situation and stronger behavioral affiliation with ingroup members than not being reminded about behavioral disinhibition. Findings of four experiments support this line of reasoning. These findings are discussed in terms of behavioral inhibition and behavioral affiliation. Alternative accounts of the data that focus on social belongingness threats and optimal distinctiveness are also considered.
Evasion of boredom: An unexpected spur to leadership?

Boredom has been largely omitted from the leadership literature, or dismissed as a problem, incongruent with effective leadership. Our research showed that the boredom discourse of senior managers engaged in a leadership development programme contrasted with their construction of challenge in leadership. In a second study, managers considered boredom to be a characteristic of followers not leaders, antithetical to leadership, and a problem to be solved through leader-initiated change. These managers therefore accepted a prevalent negative discourse on boredom and sought to respond to it not by reflecting on it but by initiating change. The experience and consideration of boredom may provide the impetus for creativity, risk-taking, curiosity and challenge-seeking, and may foster sustained and embedded individual and organizational learning. Attending to a more holistic range of phenomena and living with leadership ‘troughs’ as well as ‘peaks’ may ultimately create a more reflexive, resilient and agile leadership.
I am a woman but not this kind of woman: Bifurcation in gender identity in response to stereotype threat

The goal of this research was to investigate the effects of selective changes in feminine identity (identity bifurcation) on self-concept, cognitive functioning, and math performance of women. Study 1 showed that women highly identified with math had a tendency not to identify with stereotypically feminine characteristics that are deemed incompatible with being successful in quantitative domains (e.g., being emotional, flirtatious). At the same time, these women identified with feminine characteristics that are perceived as not incompatible with women’s success in quantitative domains (e.g., being intuitive, empathic, or fashionable). In Study 2 female participants were exposed to stereotype threat and given an opportunity to use identity bifurcation as an ego-protective strategy. Subsequently, participants’ self-esteem, working memory capacity, math performance, and self-integrity were measured. As predicted, stereotype threat negatively affected women’s math performance. However, the link between stereotype threat and math performance found in the current study was not a direct causal path, but it occurred through self-integrity and working memory acting as serial mediators. Women who were exposed to stereotype threat reported lower feelings of self-integrity, which, in turn negatively impacted their working memory capacity and undermined their math performance. Study 2 results also demonstrated that women responded to stereotype threat with bifurcation in their feminine identity. However, this change in identity did not
Strategies of oncogenic microbes to deal with WW domain-containing oxidoreductase

WW domain-containing oxidoreductase (WWOX) is a well-documented tumor suppressor protein that controls growth, survival, and metastasis of malignant cells. To counteract WWOX’s suppressive effects, cancer cells have developed many strategies either to downregulate WWOX expression or to functionally inactivate WWOX. Relatively unknown is, in the context of those cancers associated with certain viruses or bacteria, how the oncogenic pathogens deal with WWOX. Here we review recent studies showing different strategies utilized by three cancer-associated pathogens. Helicobactor pylori reduces WWOX expression through promoter hypermethylation, an epigenetic mechanism also occurring in many other cancer cells. WWOX has a potential to block canonical NF-κB activation and tumorigenesis induced by Tax, an oncoprotein of human T-cell leukemia virus. Tax successfully overcomes the blockage by inhibiting WWOX expression through activation of the non-canonical NF-κB pathway. On the other hand, latent membrane protein 2A of Epstein–Barr virus physically interacts with WWOX and redirects its function to trigger a signaling pathway that upregulates matrix metalloproteinase 9 and cancer cell invasion. These reports may be just “the tip of the iceberg” regarding multiple interactions between WWOX and oncogenic microbes. Further studies in this direction should expand our understanding of infection-driven oncogenesis.
Measuring Dispositional Optimism in Large-Scale Studies: Psychometric Evidence for German, Spanish, and Italian Versions of the Scale Optimism-Pessimism-2 (SOP2)

In different fields of the behavioral sciences, a growing demand for brief measures of psychological constructs can be observed. The current research presents new evidence on the reliability and validity of a recently developed ultra-short measure of the optimism construct sensu Scheier and Carver (1985), the German version of the Scale Optimism-Pessimism-2 (SOP2) as well as first evidence on Spanish and Italian adaptations. Reliability estimates indicate good reliability. Correlations with criteria from the nomological net of the construct are as expected. Equivalence of SOP2 factors across language versions is supported. Due to its highly efficient, yet accurate and valid measurement of the construct, the SOP2 is strongly recommended for assessment settings with severe monetary/time constraints, for example, large-scale surveys. Due to the factor equivalence, the SOP2 is also a valuable measure for cross-cultural studies.
Resilience Strategies of Male Survivors of Childhood Sexual Abuse and their Female Partners: A Phenomenological Inquiry

This phenomenological study explored the lived experience of male survivors of childhood sexual abuse (CSA) who identified as resilient in their current relationships with female partners. The study was grounded in Relational-Cultural Theory (Jordan, 2004; Miller, 1976) in order to examine the relational movements within participants' relationships with their female partners. The findings identified seven relational movements that corresponded with growth in resilience. Resilient male survivors moved from past abuse to therapeutic processing and from isolation to finding a purpose. Personal and relational challenges to resilience were self-hatred, insecurity, restricted emotionality, masculine identity crisis, and negative coping strategies. Resilient male survivors developed mutual empathy, greater trust, and deeper connections; reprocessed their masculine identity; and developed a positive vision for the future. Implications for future research and practice and study limitations are discussed.
Perfusion of the isolated trout heart coronary circulation with red blood cells: effects of oxygen supply and nitrite on coronary flow and myocardial oxygen consumption

SUMMARY A method for perfusion of the isolated trout heart coronary circulation with red blood cells (RBCs) was developed. The method was used to analyse the influence of RBC perfusion on myocardial O2 supply and O2 consumption and to test the hypothesis that nitrite is converted to vasoactive nitric oxide in the RBC-perfused coronary circulation. Perfusion with RBCs significantly increased myocardial O2 supply and O2 consumption by increasing the incoming O2 concentration and the O2 extraction. Coronary flow did not differ between RBC perfusion and saline perfusion, but RBC perfusion established a strong linear increase in myocardial O2 consumption with coronary flow. Nitric oxide was measured in the atrial effluent of the preparation. Perfusion with saline under hypoxic conditions was associated with NO production. The nitric oxide synthase inhibitor L-NA obliterated this NO production and significantly decreased coronary flow, showing that the NO was vasoactive and probably of endothelial origin. RBC perfusion at low PO2 similarly caused an L-NA-inhibitable NO production. The change in NO production upon subsequent nitrite addition, by contrast, was not inhibited by L-NA. Nitrite entered trout erythrocytes independent of degree of oxygenation, but the O2 saturation of RBCs showed a major decrease in the coronary circulation, and [NO2-] decreased while methaemoglobin rose, suggesting that deoxyHb-mediated reduction of nitrite to NO may have occurred. However, other possibilities (e.g. NO2-→NO conversion in myocardial cells) cannot be excluded. The NO formation associated with nitrite had no effect on coronary flow, possibly because NO was produced after the resistance vessels.
Genetic definition of I region‐determined antigens of the rat major histocompatibility complex

A recombinant haplotype of the major histocompatibility complex (H‐1) of the rat has been found among F2 hybrids of two congenic strains, and it has been shown previously that the major gene determining mixed lymphocyte stimulation and the Ir‐TGAL and Ir‐PheGAL genes were separated from the genes determining the classical serologically detectable histocompatibility antigens. It has been shown that the complementing Ir‐HGAL genes mapped together with the other Ir genes, and this gene cluster is assumed to represent the I region of the rat. Serological analysis of the recombinant is interpreted as showing that the Ir genes do not map in‐between the genes controlling the classical histocompatibility antigens. Thus, the sequence of the major histocompatibility genes in the rat does not seem to follow that of the mouse H‐2 system. Reciprocal immunization between the recombinant and the parental strain which shares the classical transplantation antigens but differs for the Ir genes, led t o the production of antisera which detected antigens with restricted tissue expression. These antigens were predominantly found on B lymphocytes and not on liver, brain or red blood cells and thus resembled mouse Ia antigens. Strain distribution analysis revelaed extensive cross‐reactivity with most of the H‐1 haplotypes, and two private specificities could be operationally defined. Thus, it is now possible to genetically define Ia antigens in the rat by the use of I region‐congenic strains.
Examining the Reliability and Validity of the Supports Intensity Scale–Children’s Version in Children With Autism and Intellectual Disability

This study compared the reliability, validity, and measurement properties of the Supports Intensity Scale–Children’s Version (SIS-C) in children with autism and intellectual disability (n = 2,124) and children with intellectual disability only (n = 1,861). The results suggest that SIS-C is a valid and reliable tool in both populations. Furthermore, the results of multi-group confirmatory factor analyses suggest that measurement invariance can be established across the two groups but that latent differences are present. Specifically, children with autism and intellectual disability tend to have higher intensities of support needs in social activities across age cohorts (5- to 6-, 7- to 8-, 9- to 10-, 11- to 12-, 13- to 14, and 15- to 16-year-olds), and children with intellectual disability only tended to have stronger correlations among support need domains measured on the SIS-C. Implications for applying the SIS-C to assessment and support planning are described.
Changes in Copeptin and Bioactive Vasopressin in Runners With and Without Hyponatremia

Objective:To evaluate changes in both the N-terminal (arginine vasopressin; AVP) and C-terminal (copeptin) fragments of the vasopressin prohormone before, during, and after an ultramarathon race and to assess vasopressin and copeptin concentrations in runners with and without hyponatremia. Design:Observational study. Setting:Three trials (2 sodium balance and 1 hyponatremia treatment) in 2 separate approximately 160-km footraces [Western States Endurance Run (WSER) and Javelina Jundred (JJ100)]. Participants:Six hyponatremic and 20 normonatremic runners; 19 finishers with 7 completing 100 km. Main Outcome Measures:Plasma AVP ([AVP]p), copeptin ([copeptin]p), sodium ([Na+]p), and protein (%plasma volume change; %PV) concentrations. Results:In the WSER Sodium Trial, a 3-fold prerace to postrace increase in both [AVP]p (0.7 ± 0.4 to 2.7 ± 1.9 pg/mL; P < 0.05) and [copeptin]p (10.3 ± 12.5 to 28.2 ± 16.3 pmol/L; nonsignificant) occurred, despite a 2 mEq/L decrease in [Na+]p (138.7 ± 2.3 to 136.7 ± 1.6 mEq/L; NS). A significant correlation was noted between [AVP]p and [copeptin]p postrace (r = 0.82; P < 0.05). In the WSER Treatment Trial, despite the presence of hyponatremia pretreatment versus posttreatment ([Na+]p = 130.3 vs 133.5 mEq/L, respectively), both [AVP]p (3.2 vs 2.1 pg/mL) and [copeptin]p (22.5 vs 24.9 pmol/L) were well above the detectable levels. A significant correlation was noted between [AVP]p and [copeptin]p 60 minutes after treatment (r = 0.94; P < 0.05). In the JJ100 Sodium Trial, significant correlations were found between [copeptin]p change and %PV change (r = −0.34; P < 0.05) and between [AVP]p change and [Na+]p change (r = 0.39; P < 0.05) but not vice-versa. Conclusions[Copeptin]p seems to be a reliable surrogate of stimulated [AVP]p during exercise. Nonosmotic vasopressin stimulation occurs during ultradistance running. [Copeptin]p may better reflect chronic (%PV) vasopressin secretion under conditions of endurance exercise.