Miracle-dz/UniFAR-FTUs huggingface dataset:
Multiple factors in the assessment of firesetters' fire interest and attitudes

Purpose The number of measures available to practitioners to assess fire interest and other fire-related attitudes is limited. To help establish the utility of such measures, this study explored whether three fire measures contained multiple factors and whether such factors related to firesetting behaviour. Method The Fire Interest Rating Scale, the Fire Attitude Scale, and the Identification with Fire Questionnaire were administered to 234 male prisoners (117 firesetters, 117 non-firesetters) and results were factor analyzed. To determine the relationship of the resulting factors with firesetting behaviour, their ability to discriminate firesetters from controls was examined and compared to the original scales. Results Responses were best represented by five factors, four of which discriminated firesetters from non-firesetters. One factor demonstrated significant accuracy in discriminating single offence firesetters from repeat firesetters. Taken together the factors offered more clarity than using the original scale outcomes and showed equivalent predictive accuracy. Conclusions The five factors identified may aid practitioners in helping to formulate the specific treatment needs of identified firesetters.
Balancing Interests in the Search for Occupational Legitimacy: The HR Professionalization Project in Canada

Despite broad debates surrounding how the human resource management occupation can increase its legitimacy, researchers have yet to examine the collective steps HR practitioners are taking in this regard and the extent to which they have been successful. We conduct a case study of the HR professionalization project in Canada via multisource qualitative and quantitative data, which we analyze using a unique integration of the trait and control models from the sociology of professions, as well as isomorphism from institutional theory. Viewed through the lens of these frameworks, we find that HR practitioners are attempting to emulate traits that define traditional notions of professions, and are aspiring to transcendent values associated with balancing the sometimes conflicting interests of employers and employees. Objective data from external stakeholders and institutions show that these collective strategies have been somewhat successful in garnering greater legitimacy thus far, particularly when comparisons are made with the HR professional project in the United States. We highlight numerous implications for future research and practice surrounding the legitimacy of the HR profession
Affective Information in Context and Judgment of Facial Expression

Previous research in cultural psychology suggests that North Americans are less likely than their East Asian counterparts to be sensitive to contextual information. By contrast, much evidence suggests that even North Americans’ judgments are highly influenced by affective priming information, the effect of which can be seen as another type of contextual cue. However, the magnitude of such a priming effect has not been comprehensively tested in a cross-cultural context. Taking advantage of the methodology of the affective priming paradigm, we conducted two studies, in which we manipulated (a) the timing of priming information (simultaneous vs. sequential) and (b) the type of affective information (background landscape vs. background human figures), in which European Canadians and Japanese judged target faces that showed either happy or sad facial expressions in the focal area of the scene. The results in general indicate that a similar degree of contextual effect occurs in members of both cultures. The issue of generalization of cross-cultural findings and the necessity of overarching more than one research paradigm are discussed.
Cross‐cultural group performance

Purpose – This paper aims to explore the assumption that the impact of cultural diversity on knowledge creating capability is consequent to associated differences in knowledge and perspectives, and suggests that these knowledge differences produce their effect by triggering deliberative, collaborative behaviours.Design/methodology/approach – To investigate the impact of intervening variables on diversity's impact in teams, the paper assesses whether cognitive heterogeneity operates as a mediating variable between cultural diversity and knowledge creation, and whether debate operates as a second stage mediator. The paper utilises a survey‐based, quantitative approach and collects data from 98 teams, which is analysed using causal steps approach.Findings – The results provide support for the assumed impact of cognitive heterogeneity and also support the existence of sequential mediation pathway, with debate operating as a second stage mediator between cognitive heterogeneity and knowledge creation.Originali.
Children’s Feelings of Loneliness and Social Dissatisfaction: Relationship to Measures of Physical Fitness and Activity

Approximately 600 elementary school children (Grades 1-6) completed a loneliness rating scale and several fitness tests. Children who scored within low, average, and high ranges on the loneliness scale were compared to determine whether there were differences in levels of reported performance on fitness tests. ANCOVA tests revealed that lonely children were less physically fit and physically active than were those who were not lonely. Grade-specific analyses revealed that the relationship between levels of loneliness and physical fitness/physical activity appears to be most profound at the third- and fourth-grade levels. The results from this study suggest that lonely children may lack the social and/or physical skills necessary to effectively interact and function in group settings (physical activity is often a social activity for children). This could potentially perpetuate a cycle of poor social interaction, rejection or withdrawal, reduced physical activity, and reduced physical fitness.
The p21-Dependent Radiosensitization of Human Breast Cancer Cells by MLN4924, an Investigational Inhibitor of NEDD8 Activating Enzyme

Radiotherapy is a treatment choice for local control of breast cancer. However, intrinsic radioresistance of cancer cells limits therapeutic efficacy. We have recently validated that SCF (SKP1, Cullins, and F-box protein) E3 ubiquitin ligase is an attractive radiosensitizing target. Here we tested our hypothesis that MLN4924, a newly discovered investigational small molecule inhibitor of NAE (NEDD8 Activating Enzyme) that inactivates SCF E3 ligase, could act as a novel radiosensitizing agent in breast cancer cells. Indeed, we found that MLN4924 effectively inhibited cullin neddylation, and sensitized breast cancer cells to radiation with a sensitivity enhancement ratio (SER) of 1.75 for SK-BR-3 cells and 1.32 for MCF7 cells, respectively. Mechanistically, MLN4924 significantly enhanced radiation-induced G2/M arrest in SK-BR-3 cells, but not in MCF7 cells at early time point, and enhanced radiation-induced apoptosis in both lines at later time point. However, blockage of apoptosis by Z-VAD failed to abrogate MLN4924 radiosensitization, suggesting that apoptosis was not causally related. We further showed that MLN4924 failed to enhance radiation-induced DNA damage response, but did cause minor delay in DNA damage repair. Among a number of tested SCF E3 substrates known to regulate growth arrest, apoptosis and DNA damage response, p21 was the only one showing an enhanced accumulation in MLN4924-radiation combination group, as compared to the single treatment groups. Importantly, p21 knockdown via siRNA partialy inhibited MLN4924-induced G2/M arrest and radiosensitization, indicating a causal role played by p21. Our study suggested that MLN4924 could be further developed as a novel class of radiosensitizer for the treatment of breast cancer.
Frequency and Pattern of Bone Marrow Infiltration in Patients of Hodgkin ’ s Lymphoma

Objective: To determine the frequency of bone marrow infiltration in diagnosed patients of Hodgkin’s lymphoma (HL) and to study the alterations in haematological parameters in patients with bone marrow infiltration. Material & Methods: This cross-sectional, descriptive study was conducted at the department of Pathology, Pakistan Institute of Medical Sciences (PIMS) Islamabad from January 2010 to December 2010. Sixty diagnosed cases of Hodgkin’s lymphoma referred for bone marrow examination for staging of the disease were included in the study. All the patients were subjected to blood complete picture, bone marrow aspiration and trephine biopsy. After collecting the samples, the slides of peripheral blood, bone marrow aspiration and trephine biopsy were studied microscopically. The results were entered on SPSS version 17 for final analysis. Results: Among 60 cases, median age was 18.5 years and male to female ratio was 2.5:1.The most common type observed was mixed cellularity seen in 38 (63.3%) cases. Most common clinical features observed were lymphadenopathy and pallor followed by other symptoms. Anemia was seen in 66.6% patients and leukocytosis was observed in 19% patients with bone marrow infiltration as compared to 43.5% anaemic patients and 12.8% patients with leukocytosis in patients without bone marrow infiltration. Bone marrow infiltration on trephine biopsy was seen 21 (35%) with 20 patients showing interstitial pattern. Conclusion: Frequency of bone marrow infiltration on Trephine biopsy was high in the studied group. In patients with bone marrow infiltration haemoglobin concentration and leukocyte count showed distinct alterations.
Analysis of homozygous deletion of the p16 gene and correlation with survival in patients with glioblastoma multiforme.

OBJECT One of the most frequent genetic abnormalities found in patients with glioblastoma multiforme (GBM) is homozygous deletion of the p16 tumor suppressor gene. The authors investigated whether this deletion is associated with prognosis in patients with GBM. METHODS In 46 adult patients with supratentorial GBM, homozygous deletion of the p16 gene in tumor DNA was examined using the multiplex polymerase chain reaction assay. The deletion was confirmed in 14 (30.4%) of 46 patients, eight (30.8%) of 26 men and six (30.0%) of 20 women. Cox proportional hazard regression analysis, adjusted for age at surgery, the Karnofsky Performance Scale score, extent of resection, and the MIB-1 labeling index. revealed that homozygous deletion of the p16 gene was significantly associated with overall survival and progression-free survival in men, but not in women. CONCLUSIONS The results of this study suggest that p16 homozygous deletion is a significant unfavorable prognostic factor in male patients with GBM.
Children's Adjustment to Parental Cancer: A Theoretical Model Development

There is growing empirical evidence that various child and family factors are associated with children's reactions to parental cancer. Children having parents with cancer may respond to parental cancer in different ways in terms of bonadjustment and maladjustment. Children's maladjustment to this pervasive stressor is manifested by a wide variety of physiologic, psychologic, and behavioral stress responses. To date, research on children's adjustment to parental cancer has focused almost exclusively on documenting children's adjustment problems and on describing simple, direct association between the characteristics of children and/or their families, and children's adjustment. The gap in research and clinical practice lies in the lack of a comprehensive model to illuminate children's coping with parental cancer and to guide intervention programs. Based on a synthesis of the literature, this article proposes a model that specifies the relationships among the stressor of having a parent with cancer, moderators and mediator variables, and adjustment. This model can serve as a basis for future research and intervention programs.
Verificator: Educational Tool for Learning Programming

The paper introduces Verificator, our learning programming interface aimed for learning programming in C++ at the university beginners' level. In teaching programming some specific problems concerning the teaching itself as well as the organization of the teaching process need to be considered. One of the biggest problems is that students tend to adopt certain bad programming habits in their attempt to more easily deal with their examinations, such as trying to write programs without any syntax and logical checking. It is very hard to help them correct those errors once they are deeply rooted. Our students' web questionnaire and its results show that the majority of prob- lems in learning programming among our students arise from the gap between the understanding of programming language syntax and problem-solving algorithms. Verificator prevents students from making a lot of errors they are likely to make in learning programming and helps them to learn programming language syntax and adopt good programming habits.
Doctoral supervision . . . a view from above, below and the middle!

Doctoral supervision is a complex process, and a critical success factor is the supervisory relationship. The aim of this article is to share experiences of doctoral supervision from three different perspectives, offering a view from above, below and the middle. The author was inspired by the activities associated with a recent conference. It presents reflections from three researchers at different stages of their research careers. Key themes to emerge were: the problematic transition from being an undergraduate/postgraduate student on a taught programme (a star performer) to a doctoral candidate (novice researcher, and to some extent ‘peer’), with associated issues of developing independence; the potentially problematic aspect of giving and receiving feedback, where genuine constructive critique can often be perceived as being ‘negative’ or ‘positive’ when it could be argued that all feedback is positive in its attempt to improve performance; and the development of relationships from tutor/student to critical friends and beyond, for example into mentoring roles, although again there are issues of (in)dependence.
Pseudoleptobothrium aptychotremae Young, 1967 (Monogenea, Microbothriidae) redescribed from a new host, Trygonorrhina fasciata (Rhinobatidae) in South Australia with a description of the larva and post-larval development

The adult of Pseudoleptobothrium aptychotremae Young, 1967 (Monogenea, Microbothriidae) is redescribed from the dermal denticles of the southern fiddler ray, Trygonorrhina fasciata (Rhinobatidae) collected off Adelaide, South Australia. This is a new host and locality record. The anatomy of the larva is described from observations of live larvae and the presence of six needle-like spicules in the larval haptor is confirmed. The development of P. aptychotremae is also described.
Pharmacological Treatment of Refractory Bipolar Disorder: What Does the Evidence Say?

Bipolar disorder constitutes a therapeutical challenge. In spite of intense reseach on its treatment during the last decades, the data on the treatment of refractory bipolar patients are sparse. For acutely manic patients who are partial responders to lithium, valproate or carbamazepine, a good strategy would be to add haloperidol, risperidone, olanzapine, quetiapine or aripiprazole. Adding oxcarbazepine to lithium is also a choice. The treatment of refractory bipolar depressives remains terra incognita and also there is no compelling data for the maintenance treatment of refractory patients. Patients stabilized on combination treatment might do worse if shifted from combination. Conclusively there are only limited and sometimes confusing data on the treatment of refractory bipolar patients. Further focused research is necessary on this group of patients.
LOCALISED FACE PROCESSING BY THE HUMAN PREFRONTAL CORTEX: STIMULATION-EVOKED HALLUCINATIONS OF FACES

Left and right prefrontal, premotor, and anterior temporal sites were stereotaxically implanted in order to direct surgical therapy for epilepsy. Direct electrical stimulation of the right anterior inferior frontal gyrus resulted in face-related hallucinations and illusions. When the patient was viewing a blank background, stimulation induced the experience of a rapid succession of faces. When the patient was viewing a real face, stimulation induced a series of modifications to that face. Effective stimulations induced afterdischarges that remained localised to right ventrolateral prefrontal cortex (VLPFC). Stimulation of other frontal and anterior temporal sites, bilaterally, induced no face-related hallucinations or illusions. This result supports a contribution of right VLPFC to face processing, and is consistent with models wherein it activates representations in working or declarative memories.
Ovarian dysgerminoma with retroperitoneal metastases in a bitch: a case report.

A four-year old, 26.5 kg, Boxer bitch was presented to the Department of Reproduction in the Clinic of Dogs and Cats with a six month history of vulvar swelling and vaginal discharge. General gynaecological examination showed an extremely swollen, oedematous and tough-elastic highly irritable vulva. A vaginal smear revealed the presence of superficial cells and red blood cells. After repeated unsuccesful administrations of HCG and GnRH the owner of the bitch agreed to surgical treatment. An ovariohysterectomy was performed and on the left ovary a grapefruit-size structure was found. Three nodular structures were found retroperitoneally and were also dissected. Histological examination showed a disgerminoma in metastasises, mitotically active with a bad prognosis. However, at a check up twenty months subsequently the patient was still alive.
Aspects of MMOSPA estimation

We expand upon existing literature regarding using Minimum Mean Optimal Sub-Pattern Assignment (MMOSPA) estimates in multitarget tracking, noting its advantages in comparison to Maximum Likelihood (ML) and Minimum Mean Squared Error (MMSE) estimation, and look at the practical computation of MMOSPA estimates. We demonstrate the use of MMOSPA estimation in a two-target tracking scenario as well as outside of tracking in a radar angular superresolution scenario.
CMS: A satirical critique of three narrative histories

Reflections on the 20th anniversary of Organization provide an opportunity for considerations of the role of the past and history in critical studies of management. Yet, why should we care? Arguably, the pages of Organization are replete with analyses that take into account the past and history. Indeed they are. However, as has been contended elsewhere, such accounts have been remarkably under-theorized for a field noted for its thoroughgoing critique of anything that moves. Nonetheless, it is not our intention to go over that ground so much as provide an appropriate example of the problem at hand. We do this through analysis of three selected accounts of how critical studies of management came into being as a field of study. Drawing on Hayden White’s approach to history, we analyse three histories of critical management studies through a focus on their respective narrative form, choosing to privilege our own narrative as satirical critique. Thus, the article does double duty by directly joining with the reflections on Organization and critical studies of management, while providing an argument for the need for greater theorization of the past and history. In the process we provide some clues to the development of the field of critical studies of management; problematize the associated notions of history and the past and make suggestions for future directions of what has become known as Critical Management Studies.
Incentives and Barriers for Potential Music Teacher Education Doctoral Students

The purpose of this study was to examine positive influences and barriers associated with entering a music teacher education doctoral program. Practicing music educators (N = 63), were asked to rate 48 positive-influence items and 54 barrier items. The highest-ranked positive influence was “Trainingyoung teachers to provide worthwhile educational experiences for their students, ” while the highest-ranked barrier item was “Reduction of income while working on the degree. ” Using the top 21 positive-influence items and the top 21 barrier items, two factor-analysis procedures were calculated to determine whether positive-influence and barrier items could be reduced to a smaller number of discrete factors. Four positive-influence factors (“Prestige of and Connection with Faculty/University, ” “Desire to Affect Future Music Teachers, ” “Desire to Learn, ” and “Personal/Professional Future”) and two barrier factors (“Financial Challenges” and “Family/Time Considerations”) were identified.
Expression of ANRIL–Polycomb Complexes–CDKN2A/B/ARF Genes in Breast Tumors: Identification of a Two-Gene (EZH2/CBX7) Signature with Independent Prognostic Value

ANRIL, a long noncoding RNA (lncRNA), has recently been reported to have a direct role in recruiting polycomb repressive complexes PRC2 and PRC1 to regulate the expression of the p15/CDKN2B-p16/CDKN2A-p14/ARF gene cluster. Expression analysis of ANRIL, EZH2, SUZ12, EED, JARID2, CBX7, BMI1, p16, p15, and p14/ARF genes was evaluated in a large cohort of invasive breast carcinomas (IBC, n = 456) by qRT-PCR and immunohistochemistry (IHC) was performed on CBX7, EZH2, p14, p15, p16, H3K27me3, and H3K27ac. We observed significant overexpression in IBCs of ANRIL (19.7%) and EZH2 (77.0%) and an underexpression of CBX7 (39.7%). Correlations were identified between these genes, their expression patterns, and several classical clinical and pathologic parameters, molecular subtypes, and patient outcomes, as well as with proliferation, epithelial–mesenchymal transition, and breast cancer stem cell markers. Multivariate analysis revealed that combined EZH2/CBX7 status is an independent prognostic factor (P = 0.001). In addition, several miRNAs negatively associated with CBX7 underexpression and EZH2 overexpression. These data demonstrate a complex pattern of interactions between lncRNA ANRIL, several miRNAs, PRC2/PRC1 subunits, and p15/CDKN2B-p16/CDKN2A-p14/ARF locus and suggest that their expression should be considered together to evaluate antitumoral drugs, in particular the BET bromodomain inhibitors. Implications: This study suggests that the global pattern of expression rather than expression of individual family members should be taken into account when defining functionality of repressive Polycomb complexes and therapeutic targeting potential. Mol Cancer Res; 14(7); 623–33. ©2016 AACR.