Miracle-dz/UniFAR-FTUs huggingface dataset:
ROTATIONALLY WARM MOLECULAR HYDROGEN IN THE ORION BAR

The Orion Bar is one of the nearest and best-studied photodissociation or photon-dominated regions (PDRs). Observations reveal the presence of H2 lines from vibrationally or rotationally excited upper levels that suggest warm gas temperatures (400–700 K). However, standard models of PDRs are unable to reproduce such warm rotational temperatures. In this paper, we attempt to explain these observations with new comprehensive models which extend from the H+ region through the Bar and include the magnetic field in the equation of state. We adopt the model parameters from our previous paper which successfully reproduced a wide variety of spectral observations across the Bar. In this model, the local cosmic ray density is enhanced above the galactic background, as is the magnetic field, and which increases the cosmic ray heating elevating the temperature in the molecular region. The pressure is further enhanced above the gas pressure in the H+ region by the momentum transferred from the absorbed starlight. Here, we investigate whether the observed H2 lines can be reproduced with standard assumptions concerning the grain photoelectric emission. We also explore the effects due to the inclusion of recently computed H2 + H2, H2 + H, and H2 + He collisional rate coefficients.
The hubs of the human connectome are generally implicated in the anatomy of brain disorders

See Sporns (doi:10.1093/brain/awu148) for a scientific commentary on this article. Brain networks contain a minority of highly connected hub nodes with high topological value and biological cost. Using network analysis of DTI data from healthy volunteers, and meta-analyses of published MRI studies in 26 brain disorders, Crossley et al. show that lesions across disorders tend to be concentrated at hubs.
De novo mutation in the RP1 gene (Arg677ter) associated with retinitis pigmentosa.

PURPOSE The Arg677ter mutation in the RP1 gene is one of the most common causes of autosomal dominant retinitis pigmentosa (RP). In the current study, a de novo Arg677ter RP1 gene mutation was identified in a patient with RP. METHODS RP1 gene mutation screening was performed in probands with simplex RP. In one proband with the RP1 mutation, paternity was established by analyzing 24 short tandem repeat polymorphisms. Additional candidate RP genes, including rhodopsin, RDS/peripherin, RP2, and RPGR, were also examined in this proband. Phenotype was characterized with psychophysics, electroretinography, and optical coherence tomography. RESULTS An RP1 (Arg677ter) mutation was identified in one of the patients with simplex RP, but the sequence change was not detected in his parents. Parentage was confirmed, and other candidate genes were negative for mutations. Retinal function and cross-sectional imaging studies in the patient indicated greater rod than cone dysfunction with a photoreceptor basis for the abnormalities. CONCLUSIONS The de novo origin of an RP1 (Arg677ter) mutation in a patient with simplex RP suggests that this common autosomal dominant RP mutation can arise independently in the population and supports the hypothesis of a mutational hotspot in the RP1 gene.
Classical and numerical approaches to determining V-section band clamp axial stiffness

Abstract V-band clamp joints are used in a wide range of applications to connect circular flanges, for ducts, pipes and the turbocharger housing. Previous studies and research on V-bands are either purely empirical or analytical with limited applicability on the variety of V-band design and working conditions. In this paper models of the V-band are developed based on the classical theory of solid mechanics and the finite element method to study the behaviour of theV-bands under axial loading conditions. The good agreement between results from the developed FEA and the classical model support the suitability of the latter to modelV-band joints with diameters greater than 110mm under axial loading. The results from both models suggest that the axial stiffness for thisV-band cross section reaches a peak value for V-bands with radius of approximately 150 mmacross a wide range of coefficients of friction. Also, it is shown that the coefficient of friction and the wedge angle have a significant effect on the axial stiffness of V-bands.
The Taipan Galaxy Survey: Scientific Goals and Observing Strategy

Abstract The Taipan galaxy survey (hereafter simply ‘Taipan’) is a multi-object spectroscopic survey starting in 2017 that will cover 2π steradians over the southern sky (δ ≲ 10°, |b| ≳ 10°), and obtain optical spectra for about two million galaxies out to z < 0.4. Taipan will use the newly refurbished 1.2-m UK Schmidt Telescope at Siding Spring Observatory with the new TAIPAN instrument, which includes an innovative ‘Starbugs’ positioning system capable of rapidly and simultaneously deploying up to 150 spectroscopic fibres (and up to 300 with a proposed upgrade) over the 6° diameter focal plane, and a purpose-built spectrograph operating in the range from 370 to 870 nm with resolving power R ≳ 2000. The main scientific goals of Taipan are (i) to measure the distance scale of the Universe (primarily governed by the local expansion rate, H 0) to 1% precision, and the growth rate of structure to 5%; (ii) to make the most extensive map yet constructed of the total mass distribution and motions in the local Universe, using peculiar velocities based on improved Fundamental Plane distances, which will enable sensitive tests of gravitational physics; and (iii) to deliver a legacy sample of low-redshift galaxies as a unique laboratory for studying galaxy evolution as a function of dark matter halo and stellar mass and environment. The final survey, which will be completed within 5 yrs, will consist of a complete magnitude-limited sample (i ⩽ 17) of about 1.2 × 106 galaxies supplemented by an extension to higher redshifts and fainter magnitudes (i ⩽ 18.1) of a luminous red galaxy sample of about 0.8 × 106 galaxies. Observations and data processing will be carried out remotely and in a fully automated way, using a purpose-built automated ‘virtual observer’ software and an automated data reduction pipeline. The Taipan survey is deliberately designed to maximise its legacy value by complementing and enhancing current and planned surveys of the southern sky at wavelengths from the optical to the radio; it will become the primary redshift and optical spectroscopic reference catalogue for the local extragalactic Universe in the southern sky for the coming decade.
Poor sleep is associated with impaired cognitive function in older women: the study of osteoporotic fractures.

BACKGROUND The association between objectively measured sleep and cognition among community-dwelling elderly persons remains understudied. This observational, cross-sectional analysis examined this association. METHODS Results are from 2932 women (mean age 83.5 years) in the Study of Osteoporotic Fractures between 2002 and 2004. Cognitive function was measured by Mini-Mental State Examination (MMSE) and Trail Making B Test (Trails B). Cognitive impairment was defined as MMSE < 26 or Trails B > 278 seconds. Sleep parameters measured objectively using actigraphy included total sleep time, sleep efficiency, sleep latency, wake after sleep onset (WASO), and total nap time. RESULTS There were 305 women (10.6%) with MMSE < 26 and 257 women (9.3%) with Trails B > 278 seconds. Compared with women with sleep efficiency > or = 70%, those with <70% had a higher risk of cognitive impairment (MMSE < 26 multivariate odds ratio [MOR] = 1.61; 95% confidence interval [CI], 1.20-2.16; Trails B > 278 MOR = 1.96; 95% CI, 1.43-2.67). Higher sleep latency was associated with higher risk of cognitive impairment (per half hour: MMSE < 26 MOR = 1.23; 95% CI, 1.13-1.33; Trails B > 278 MOR = 1.13; 95% CI, 1.04-1.24), as was higher WASO (per half hour: MMSE < 26 MOR = 1.15; 95% CI, 1.06-1.23; Trails B > 278 MOR = 1.24; 95% CI, 1.15-1.34). Women who napped > or = 2 hours per day had a higher risk (MMSE < 26 MOR = 1.42; 95% CI, 1.05-1.93; Trails B > 278 MOR = 1.74; 95% CI, 1.26-2.40). There was no significant relationship for total sleep time. CONCLUSION Objectively measured disturbed sleep was consistently related to poorer cognition, whereas total sleep time was not. This finding may suggest that it is disturbance of sleep rather than quantity that affects cognition.
An Oscillatory Stability Criterion Based on the Unified $dq$ -Frame Impedance Network Model for Power Systems With High-Penetration Renewables

Recent years have witnessed emerging oscillatory stability issues in power systems with high-penetration renewables. These issues are generally caused by the dynamic interaction between the AC/DC grid and power electronic converters used for the integration of renewables. Some previous studies have explored the issues with simplified system models containing only a few converters and idealized networks. However, the interactions between many converters and traditional generators/HVDCs have not been fully considered. To fill this gap, this paper first presents the concept of a unified dq frame impedance network model (INM), with which different converters as well as traditional generators/HVDCs can be incorporated to form an integrated s-domain model of a practical system. As the INM is aggregated into a lumped impedance matrix, a new criterion is then proposed to quantify the oscillatory stability, just by analyzing the frequency characteristics of the determinant of the matrix. Finally, the modeling method and the stability criterion are applied to a real-world system with a very high share of renewables and a realistic risk of oscillatory instability. Their effectiveness has been validated by both field measurements and electromagnetic transient simulations.
A Framework for Combining Seasonal Forecasts and Climate Projections to Aid Risk Management for Fisheries and Aquaculture

A changing climate, in particular a warming ocean, is likely to impact marine industries in a variety of ways. For example, aquaculture businesses may not be able to maintain production in their current location into the future, or area-restricted fisheries may need to follow the fish as they change distribution. Preparation for these potential climate impacts can be improved with information about the future. Such information can support a risk-based management strategy for industries exposed to both short-term environmental variability and long-term change. In southern Australia, adverse climate impacts on valuable seafood industries have occurred, and they are now seeking advice about future environmental conditions. We introduce a decision tree to explain the potential use of long-term climate projections and seasonal forecasts by these industries. Climate projections provide insight into the likely time in the future when current locations will no longer be suitable for growing or catching particular species. Until this time, seasonal forecasting is beneficial in helping industries plan ahead to reduce impacts in poor years and maximise opportunities in good years. Use of seasonal forecasting can extend the period of time in which industries can cope in a location as environmental suitability declines due to climate change. While a range of short-term forecasting approaches exist, including persistence and climatological forecasts, only dynamic model forecasts provide a viable option for managing environmental risk for marine industries in regions where climate change is reducing environmental suitability and creating novel conditions.
The Flexibility of Fertility Preferences in a Context of Uncertainty

FROM RYDER’S (1973) “cloudy future” to Lee’s (1980) “moving target,” the malleable nature of fertility preferences is widely accepted; however, tools for conceptualizing and measuring preferences have been slow to evolve. In this article, we seek to demonstrate that underpinning the number people give when asked about their ideal family size, and critical to interpreting it, is either a rigidness or a flexibility that is contextually situated and dynamic over the life course. To illustrate the difference between fixed and flexible orientations to fertility, we draw upon the metaphor of a movable feast. While some religious holidays like Christmas and All Souls Day occur annually on fixed days, others like Passover, Easter, and Pentecost change from year to year depending upon the lunar cycle or other ecclesiastical dates. From the perspective of the Gregorian calendar, movable feasts seem irregular, unpredictable, and sometimes merely seasonal. But movable feasts are no less regular than fixed feasts, nor are they of secondary importance; they differ in being governed by a distinct, flexible logic. Like many major religious feasts, some people’s fertility preferences are indeed fixed, but it is the movable ones we endeavor to theorize here. Our interest in flexibility is anchored in two recent empirical and theoretical developments in the demographic literature. First, although instability in fertility preferences is higher in developing contexts than in the West (Bankole and Westoff 1995; Kodzi, Johnson, and Casterline 2010), new evidence suggests that this preference instability is not simply random noise but frequently patterned. In Malawi, for example, the setting of our present study, women change their numeric and timing preferences in response to changes in their relationships (divorce, widowhood, new marriage) and reproductive circumstances (pregnancies and child mortality) (Sennott and Yeatman 2012; Yeatman, Sennott, and Culpepper 2013). Furthermore, instability itself has predictive power with respect to short-term fertility outcomes (Kodzi et al. 2010).
Tumor Necrosis Factor-α–Induced Apoptosis in Murine Cytomegalovirus Retinitis

PURPOSE Previous results suggest that apoptosis is involved in the pathogenesis of murine cytomegalovirus (MCMV) retinitis. To explore the mechanism underlying retinal apoptosis in MCMV retinitis, this study was initiated to determine whether the tumor necrosis factor receptor (TNFR)1-TNF pathway is involved in apoptosis during MCMV retinitis. METHODS The left eyes of nonimmunosuppressed (non-IS) BALB/c mice, immunosuppressed (IS) BALB/c mice, TNFR1(-/-) C57BL/6 mice, and wild-type C57BL/6 mice were inoculated with MCMV k181 by way of the supraciliary route. On postinoculation days 3, 7, and 10, injected eyes of non-IS control and IS experimental mice were removed for RT-PCR for TNF-alpha and TNFR1. Protein expression of TNF-alpha, caspase-8, and caspase-3 was determined by staining frozen sections and performing Western blot analysis and quantitative ELISA. Apoptotic cells were identified by TUNEL labeling. RESULTS In IS BALB/c mice, TNF-alpha mRNA and protein were detected in MCMV-infected eyes throughout the infection. Activation of caspase-3 and caspase-8 was observed. Most of the TNF-alpha-expressing cells were MCMV-infected RPE cells or macrophages derived from RPE cells. TNF-alpha was observed in the area of apoptotic retinal cells, and the level of this cytokine corresponded to the extent of the retinal abnormality and to the number of apoptotic cells. In non-IS MCMV-infected BALB/c mice, TNF-alpha was expressed early in the retinas of MCMV-infected eyes, but its expression was decreased thereafter. TNFR1 mRNA was increased in IS and non-IS BALB/c after MCMV infection. More apoptotic cells were observed in the retinas of non-IS MCMV-infected wild-type C57BL/6 mice than in the retinas of non-IS TNFR(-/-) mice. CONCLUSIONS These results suggest that the TNFR1-TNF pathway is involved in the induction of apoptosis and the exacerbation of retinal abnormality during MCMV retinitis. Furthermore, because TNF-alpha and TNFR1 were present in IS and non-IS mice, TNF-alpha-induced retinal apoptosis during MCMV infection is not T-cell dependent.
Banking on Deposits: Maturity Transformation Without Interest Rate Risk

We show that maturity transformation does not expose banks to significant interest rate risk---it actually hedges banks' interest rate risk. We argue that this is driven by banks' deposit franchise. Banks incur large operating costs to maintain their deposit franchise, and in return get substantial market power. Market power allows banks to charge depositors a spread by paying deposit rates that are low and insensitive to market rates. The deposit franchise therefore works like an interest rate swap where banks pay the fixed-rate leg (the operating costs) and receive the floating-rate leg (the deposit spread). To hedge the deposit franchise, banks must therefore hold long-term fixed-rate assets; i.e., they must engage in maturity transformation. Consistent with this view, we show that banks' aggregate net interest margins have been highly stable and insensitive to interest rates over the past six decades, and that banks' equity values are largely insulated from monetary policy shocks. Moreover, in the cross section we find that banks match the interest-rate sensitivities of their income and expenses one-for-one, and that banks with less sensitive interest expenses hold substantially more long-term assets. Our results imply that forcing banks to hold only short-term assets (``narrow banking'') would make banks unhedged and, more broadly, that the deposit franchise is what allows banks to lend long term.
Convolution in Convolution for Network in Network

Network in network (NiN) is an effective instance and an important extension of deep convolutional neural network consisting of alternating convolutional layers and pooling layers. Instead of using a linear filter for convolution, NiN utilizes shallow multilayer perceptron (MLP), a nonlinear function, to replace the linear filter. Because of the powerfulness of MLP and $ 1\times 1 $ convolutions in spatial domain, NiN has stronger ability of feature representation and hence results in better recognition performance. However, MLP itself consists of fully connected layers that give rise to a large number of parameters. In this paper, we propose to replace dense shallow MLP with sparse shallow MLP. One or more layers of the sparse shallow MLP are sparely connected in the channel dimension or channel–spatial domain. The proposed method is implemented by applying unshared convolution across the channel dimension and applying shared convolution across the spatial dimension in some computational layers. The proposed method is called convolution in convolution (CiC). The experimental results on the CIFAR10 data set, augmented CIFAR10 data set, and CIFAR100 data set demonstrate the effectiveness of the proposed CiC method.
Evidence against Functionally Significant Aquaporin Expression in Mitochondria*

Recent reports suggest the expression of aquaporin (AQP)-type water channels in mitochondria from liver (AQP8) (Calamita, G., Ferri, D., Gena, P., Liquori, G. E., Cavalier, A., Thomas, D., and Svelto, M. (2005) J. Biol. Chem. 280, 17149–17153) and brain (AQP9) (Amiry-Moghaddam, M., Lindland, H., Zelenin, S., Roberg, B. A., Gundersen, B. B., Petersen, P., Rinvik, E., Torgner, I. A., and Ottersen, O. P. (2005) FASEB J. 19, 1459–1467), where they were speculated to be involved in metabolism, apoptosis, and Parkinson disease. Here, we systematically examined the functional consequence of AQP expression in mitochondria by measurement of water and glycerol permeabilities in mitochondrial membrane preparations from rat brain, liver, and kidney and from wild-type versus knock-out mice deficient in AQPs -1, -4, or -8. Osmotic water permeability, measured by stopped-flow light scattering, was similar in all mitochondrial preparations, with a permeability coefficient Pf ∼ 0.009 cm/s. Glycerol permeability was also similar (∼5 × 10–6 cm/s) in the various preparations. HgCl2 slowed osmotic equilibration comparably in mitochondria from wild-type and AQP-deficient mice, although the slowing was explained by altered mitochondrial size rather than reduced Pf. Immunoblot analysis of mouse liver mitochondria failed to detect AQP8 expression, with liver homogenates from wild-type/AQP8 null mice as positive/negative controls. Our results provide evidence against functionally significant AQP expression in mitochondria, which is consistent with the high mitochondrial surface-to-volume ratio producing millisecond osmotic equilibration, even when intrinsic membrane water permeability is not high.
Water-splitting chemistry of photosystem II.

Life on earth is almost entirely solar-powered. We can get some idea of the enormous quantity of energy received from the sun by noting that during daylight hours, the sun provides several thousand times more power to the surface of the U.S.A. than is produced by all of the nation’s electrical power stations. 1,2 Around 50% of the radiation that reaches the earth’s surface, roughly the visible region, is of a frequency useful to photosynthetic organisms. Oxygenic photosynthetic organisms convert this radiation into chemical energy, in the form of carbohydrate and dioxygen, at an optimal efficiency of something like 25%. 3 These products together sustain the rest of aerobic life, with carbohydrate acting as a source of high-energy electrons and dioxygen providing a lower-energy destination for these electrons. The overall equation of oxygenic photosynthesis is given in eq 1, where (CH2O) represents carbohydrate:
CSF/serum matrix metallopeptidase‐9 ratio discriminates neuro Behçet from multiple sclerosis

In neuro Behçet disease with multiple sclerosis‐like features, diagnosis could be challenging. Here, we studied the cerebrospinal fluid and serum inflammatory profile of 11 neuro Behçet and 21 relapsing‐remitting multiple sclerosis patients. Between the soluble factors analyzed (MMP9, TNFα, IL6, CXCL13, CXCL10, CXCL8, IFNγ, IL10, IL17, IL23, and others) we found MMP9 increased in neuro Behçet serum compared to multiple sclerosis and decreased in cerebrospinal fluid. Furthermore, neuro Behçet analysis of circulating natural killer CD56DIM subset suggests their potential involvement in increased MMP9 production. We believe that these findings may have a translational utility in clinical practice.