Miracle-dz/UniFAR-FTUs huggingface dataset:
Fluctuation of magnitude of wave loads for a long array of bottom-mounted cylinders

For wave loads on cylinders constituting a long but finite array in the presence of incident waves, variations in the magnitude of the load with the non-dimensional wavenumber exhibit interesting features. Towering spikes and nearby secondary peaks (troughs) associated with trapped modes have been studied extensively. Larger non-trapped regions other than these two are termed Region III in this study. Studies of Region III are rare. We find that fluctuations in Region III are regular; the horizontal distance between two adjacent local maximum/minimum points, termed fluctuation spacing, is constant and does not change with non-dimensional wavenumbers. Fluctuation spacing is related only to the total number of cylinders in the array, identification serial number of the cylinder concerned and wave incidence angle. Based on the interaction theory and constructive/destructive interference, we demonstrate that the fluctuation characteristics can be predicted using simple analytical formulae. The formulae for predicting fluctuation spacing and the abscissae of every peak and trough in Region III are proposed. We reveal the intrinsic mechanism of the fluctuation phenomenon. When the diffraction waves emitted from the cylinders at the ends of the array and the cylinder concerned interfere constructively/destructively, peaks/troughs are formed. The fluctuation phenomenon in Region III is related to solutions of inhomogeneous equations. By contrast, spikes and secondary peaks are associated with solutions of the eigenvalue problem. This study of Region III complements existing understanding of the characteristics of the magnitude of wave load. The engineering significances of the results are discussed as well.
Reversal of electrophysiologic and hemodynamic effects induced by high dose of bupivacaine by the combination of clonidine and dobutamine in anesthetized dogs.

The ability of clonidine and dobutamine to correct bupivacaine-induced cardiac electrophysiologic and hemodynamic impairment was evaluated in an experimental electrophysiologic model on closed-chest dogs. Five groups (n = 6) of pentobarbital-anesthetized dogs were given atropine (0.2 mg/kg IV). Group 1 was given a saline solution; all other dogs were given bupivacaine (4 mg/kg IV) over a 10-s period. Group 2 was given only bupivacaine. Group 3 was given clonidine (0.01 mg/kg IV) over a 1-min period. Group 4 was given a dobutamine infusion at 5 micrograms.kg-1.min-1. Group 5 was given the combination of clonidine and dobutamine. Bupivacaine induced bradycardia, prolonged atrioventricular conduction time (PR interval), atrioventricular node conduction time (AH interval), His-Purkinje conduction time (HV interval), and QRS duration. Bupivacaine decreased left ventricular (LV) dP/dt max and increased LV end-diastolic pressure (LVEDP). Clonidine improved QRS duration and HV interval but enhanced AH interval, bradycardia, and hemodynamic depression induced by bupivacaine. Dobutamine infusion improved LV dP/dt max but did not modify bupivacaine-induced ventricular electrophysiologic impairment. The combination of clonidine and dobutamine corrected not only the electrophysiologic impairment induced by bupivacaine but also the hemodynamic depression. As the HV interval and the QRS duration could be correlated with ventricular conduction velocities, we conclude that (a) clonidine reversed the slowing of ventricular conduction velocities induced by bupivacaine, and (b) the combination of clonidine and dobutamine was able to correct the cardiac disturbances induced by bupivacaine in anesthetized dogs.
Near-Optimal Access Partitioning for Memory Hierarchies with Multiple Heterogeneous Bandwidth Sources

The memory wall continues to be a major performance bottleneck. While small on-die caches have been effective so far in hiding this bottleneck, the ever-increasing footprint of modern applications renders such caches ineffective. Recent advances in memory technologies like embedded DRAM (eDRAM) and High Bandwidth Memory (HBM) have enabled the integration of large memories on the CPU package as an additional source of bandwidth other than the DDR main memory. Because of limited capacity, these memories are typically implemented as a memory-side cache. Driven by traditional wisdom, many of the optimizations that target improving system performance have been tried to maximize the hit rate of the memory-side cache. A higher hit rate enables better utilization of the cache, and is therefore believed to result in higher performance. In this paper, we challenge this traditional wisdom and present DAP, a Dynamic Access Partitioning algorithm that sacrifices cache hit rates to exploit under-utilized bandwidth available at main memory. DAP achieves a near-optimal bandwidth partitioning between the memory-side cache and main memory by using a light-weight learning mechanism that needs just sixteen bytes of additional hardware. Simulation results show a 13% average performance gain when DAP is implemented on top of a die-stacked memory-side DRAM cache. We also show that DAP delivers large performance benefits across different implementations, bandwidth points, and capacity points of the memory-side cache, making it a valuable addition to any current or future systems based on multiple heterogeneous bandwidth sources beyond the on-chip SRAM cache hierarchy.
De-epoxidation of Violaxanthin after Reconstitution into Different Carotenoid Binding Sites of Light-harvesting Complex II*

In higher plants, the de-epoxidation of violaxanthin (Vx) to antheraxanthin and zeaxanthin is required for the pH-dependent dissipation of excess light energy as heat and by that process plays an important role in the protection against photo-oxidative damage. The de-epoxidation reaction was investigated in an in vitro system using reconstituted light-harvesting complex II (LHCII) and a thylakoid raw extract enriched in the enzyme Vx de-epoxidase. Reconstitution of LHCII with varying carotenoids was performed to replace lutein and/or neoxanthin, which are bound to the native complex, by Vx. Recombinant LHCII containing either 2 lutein and 1 Vx or 1.6 Vx and 1.1 neoxanthin or 2.8 Vx per monomer were studied. Vx de-epoxidation was inducible for all complexes after the addition of Vx de-epoxidase but to different extents and with different kinetics in each complex. Analysis of the kinetics indicated that the three possible Vx binding sites have at least two, and perhaps three, specific rate constants for de-epoxidation. In particular, Vx bound to one of the two lutein binding sites of the native complex, most likely L1, was not at all or only at a slow rate convertible to Zx. In reisolated LHCII, newly formed Zx almost stoichiometrically replaced the transformed Vx, indicating that LHCII and Vx de-epoxidase stayed in close contact during the de-epoxidation reactions and that no release of carotenoids occurred.
UvA-DARE (Digital Academic Repository) A review on sex differences in processing emotional signals

Interest in sex-related differences in psychological functioning has again come to the foreground with new ﬁndings about their possible functional basis in the brain. Sex differences may be one way how evolution has capitalized on the capacity of homologous brain regions to process social information between men and women differently. This paper focuses speciﬁcally on the effects of emotional valence, sex of the observed and sex of the observer on regional brain activations. We also discuss the effects of and interactions between environment, hormones, genes and structural differences of the brain in the context of differential brain activity patterns between men and women following exposure to seen expressions of emotion and in this context we outline a number of methodological considerations for future research. Importantly, results show that although women are better at recognizing emotions and express themselves more easily, men show greater responses to threatening cues (dominant, violent or aggressive) and this may reﬂect different behavioral response tendencies between men and women as well as evolutionary effects. We conclude that sex differences must not be ignored in affective research and more speciﬁcally in affective neuroscience.
Diagnostic Utility of CD44 Standard, CD44v6, and CD44v3-10 Expression in Adenocarcinomas Presenting in Serous Fluids

CD44 is an 85 to 90 kd integral transmembrane protein encoded by a single 20-exon gene located on the short arm of chromosome 11. In the standard form (CD44s), 10 of the 20 exons are transcribed. Multiple variant isoforms exist (CD44v1-10) which arise from alternate mRNA splicing of the remaining 10 exons. In contrast to the standard form of CD44, which is almost ubiquitously expressed, splice variants are highly restricted in their expression in normal or malignant tissues. The purpose of this study was to evaluate the extent to which metastatic adenocarcinomas in effusions express CD44s, CD44v6, and CD44v3-10 and to assess their diagnostic utility in distinguishing reactive mesothelial cells from adenocarcinomas. Archival paraffin-embedded cell blocks of serous fluids from 23 cases of benign effusions containing reactive mesothelial cells and 45 cases of malignant effusions with metastatic adenocarcinoma (18 ovarian, 11 pulmonary, 9 gastrointestinal, and 7 breast) were retrieved from the surgical pathology files. The cytopathology of all cases was reviewed to confirm the diagnosis. Immunohistochemistry was performed on all cases using antibodies for CD44s, CD44v6, and CD44v3-10 (Bender MedSystems, CA). Positive staining was defined as distinct linear membrane staining. Strong staining in at least 10% of the tumor cells was required to consider the case positive for the particular marker. In benign effusions mesothelial cells expressed CD44s in 22 cases (96%), CD44v6 in 1 cases (4%) and CD44v3-10 in 0 cases (0%). In contrast neoplastic cells in malignant effusions expressed CD44s in 11 cases (24%), CD44v6 in 21 cases (47%), and CD44v3-10 in 39 cases (87%). We concluded that CD44s and CD44v3-10 are useful markers that can be applied to cytologic specimens. CD44s immunostaining can be used as a reliable marker to identify reactive mesothelial cells, meanwhile CD44v3-10 immunostaining can detect majority of adenocarcinomas in malignant effusions.
Conditional edge-fault-tolerant Hamiltonian cycle embedding of star graphs

The star graph has been recognized as an attractive alternative to the hypercube. In this paper, we investigate the hamiltoncity of a n-dimensional star graph. We show that for any n-dimensional star graph (n ges 4) with at most 3n - 10 faulty edges in which each node is incident to at least two fault-free edges, there exists a fault-free Hamiltonian cycle. Our result improves the previously best known result where the number of tolerable faulty edges is bounded by 2n - 7. We also demonstrate that our result is optimal with respect to the worst case scenario where every other node of a six-length cycle is incident to exactly n - 3 faulty non-cycle edges.
Associations between selected allergens, phthalates, nicotine, polycyclic aromatic hydrocarbons, and bedroom ventilation and clinically confirmed asthma, rhinoconjunctivitis, and atopic dermatitis in preschool children.

Previous studies, often using data from questionnaires, have reported associations between various characteristics of indoor environments and allergic disease. The aim of this study has been to investigate possible associations between objectively assessed indoor environmental factors and clinically confirmed asthma, rhinoconjunctivitis, and atopic dermatitis. The study is a cross-sectional case-control study of 500 children aged 3-5 years from Odense, Denmark. The 200 cases had at least two parentally reported allergic diseases, while the 300 controls were randomly selected from 2835 participating families. A single physician conducted clinical examinations of all 500 children. Children from the initially random control group with clinically confirmed allergic disease were subsequently excluded from the control group and admitted in the case group, leaving 242 in the healthy control group. For most children, specific IgE's against various allergens were determined. In parallel, dust samples were collected and air change rates were measured in the children's bedrooms. The dust samples were analyzed for phthalate esters, polycyclic aromatic hydrocarbons (PAH), nicotine, and various allergens. Among children diagnosed with asthma, concentrations of nicotine were higher (P < 0.05) and cat allergens were lower (P < 0.05) compared with the healthy controls; air change rates were lower for those sensitized (specific IgE+) compared with those not sensitized (specific IgE-, P < 0.05); and dust mite allergens were higher for specific IgE+ cases compared with healthy controls (P < 0.05). When disease status was based solely on questionnaire responses (as opposed to physician diagnosis), significant associations were found between di(2-ethylhexyl) phthalate (DEHP) and dog allergens in dust and current wheeze.
Physical Illness

Reports have appeared in the literature suggesting an association between physical illness and the later development of anorexia nervosa. The histories of 326 patients with anorexia nervosa were examined for physical illness. A higher rate of severe physical illness was found in this group when compared with controls suggesting that it should be regarded as a risk factor for anorexia nervosa. No statistically significant differences were found when illness was examined by time in relation to onset of anorexia, system involved, or when subjects were stratified by age. Possible explanations for the observed association are discussed.
Long-Term Clinical and Echocardiographic Outcome in Patients with CRT and Functional Mitral Regurgitation: MitraClip versus Optimal Medical Therapy

Objectives: This study sought to evaluate the clinical outcome in cardiac resynchronization therapy (CRT) patients with residual moderate-to-severe functional mitral regurgitation (FMR) who underwent percutaneous treatment with the Mitraclip System or were managed with medical therapy alone. Background: Significant FMR can persist in 20-25% of patients after CRT and its management can be a challenge, due to the advanced heart failure (HF) and a variety of concomitant comorbidities. Methods: From a single center, two different groups of patients with CRT (MitraClip and no-MitraClip group) were compared. Clinical follow-up was scheduled at 30-day, 12 months and 24 months in all patients. The primary endpoint was the composite of all-cause death or HF hospitalizations at 24-month follow-up. Results: Forty patients (56%) were treated with the Mitraclip System (MitraClip group) and 31 patients (44%) only with medical therapy (no-MitraClip group). MitraClip group presented higher surgical risk than no-MitraClip group, as older age, chronic kidney disease, higher NYHA functional class and lower left ventricular ejection fraction. At 24-month no differences in all-cause mortality were detected between the two groups (Kaplan-Meier curves log-rank p = 0.947), although the MitraClip group presented lower rate of HF hospitalizations than the no-MitraClip group (log-rank p = 0.048). After adjustment for confounding factors, time to HF hospitalization or death was significantly delayed in MitraClip group (hazard ratio: 0.38; p-value 0.018). Conclusion: In CRT patients, the treatment of moderateto-severe FMR with the Mitraclip System if compared to medical therapy alone is a safe and effective approach in reducing cardiac symptoms and the rate of hospitalizations for HF.
Self-monitoring and other non-pharmacological interventions to improve the management of hypertension in primary care: a systematic review.

BACKGROUND Patients with high blood pressure (hypertension) in the community frequently fail to meet treatment goals: a condition labelled as 'uncontrolled' hypertension. The optimal way to organise and deliver care to hypertensive patients has not been clearly identified. AIM To determine the effectiveness of interventions to improve control of blood pressure in patients with hypertension. DESIGN OF STUDY Systematic review of randomised controlled trials. SETTING Primary and ambulatory care. METHOD Interventions were categorised as following: self-monitoring; educational interventions directed to the patient; educational interventions directed to the health professional; health professional- (nurse or pharmacist) led care; organisational interventions that aimed to improve the delivery of care; and appointment reminder systems. Outcomes assessed were mean systolic and diastolic blood pressure, control of blood pressure and proportion of patients followed up at clinic. RESULTS Seventy-two RCTs met the inclusion criteria. The trials showed a wide variety of methodological quality. Self-monitoring was associated with net reductions in systolic blood pressure (weighted mean difference [WMD] -2.5 mmHg, 95%CI = -3.7 to -1.3 mmHg) and diastolic blood pressure (WMD -1.8 mmHg, 95%CI = -2.4 to -1.2 mmHg). An organised system of regular review allied to vigorous antihypertensive drug therapy was shown to reduce blood pressure and all-cause mortality in a single large randomised controlled trial. CONCLUSION Antihypertensive drug therapy should be implemented by means of a vigorous stepped care approach when patients do not reach target blood pressure levels. Self-monitoring is a useful adjunct to care while reminder systems and nurse/pharmacist -led care require further evaluation.
On the Design of Hybrid Automatic Repeat Request Schemes with Unreliable Feedback

\gls{HARQ} schemes are employed in mobile communication systems to reduce the residual Frame Error Rate (FER) after channel decoding. If decoding fails, the receiver requests the transmission of additional redundancy about these frames to improve the decoding success. Signaling is carried out over a feedback link from the receiver back to the transmitter. However, errors on the feedback link severely influence the behavior of the HARQ system and may degrade the overall system performance. In this contribution, the impact of HARQ signaling errors on the FER, the average number of HARQ transmissions per frame, and the system throughput is investigated. We derive analytical expressions for all performance measures based on FER simulations of the HARQ system with reliable feedback. The theoretical results are verified by the example of the LTE physical layer, however, they are also applicable to other communication systems. Moreover, target requirements for the maximum tolerable feedback error probabilities are derived which are used to develop design guidelines for HARQ feedback transceivers.
Growth hormone signaling is necessary for lifespan extension by dietary methionine

Growth hormone significantly impacts lifespan in mammals. Mouse longevity is extended when growth hormone (GH) signaling is interrupted but markedly shortened with high‐plasma hormone levels. Methionine metabolism is enhanced in growth hormone deficiency, for example, in the Ames dwarf, but suppressed in GH transgenic mice. Methionine intake affects also lifespan, and thus, GH mutant mice and respective wild‐type littermates were fed 0.16%, 0.43%, or 1.3% methionine to evaluate the interaction between hormone status and methionine. All wild‐type and GH transgenic mice lived longer when fed 0.16% methionine but not when fed higher levels. In contrast, animals without growth hormone signaling due to hormone deficiency or resistance did not respond to altered levels of methionine in terms of lifespan, body weight, or food consumption. Taken together, our results suggest that the presence of growth hormone is necessary to sense dietary methionine changes, thus strongly linking growth and lifespan to amino acid availability.
On the Phase Structure of the 3D Edwards Anderson Spin Glass

We characterize numerically the properties of the phase transition of the three dimensional Ising spin glass with Gaussian couplings and of the low temperature phase. We compute critical exponents on large lattices. We study in detail the overlap probability distribution and the equilibrium overlap-overlap correlation functions. We find a clear agreement with off-equilibrium results from previous work. These results strongly support the existence of a continuous spontaneous replica symmetry breaking in three dimensional spin glasses. PACS mumbers: 75.50. Lk, 05.50. +q, 64.60. Cn
Does the dorsal hippocampus process navigational routes or behavioral context? A single‐unit analysis

In humans the hippocampus plays a role in both episodic memory and spatial navigation. Similar findings have been shown in other animals including monkeys and rats. The relationship between the processing of episodic and spatial related inputs within the hippocampus remains a puzzle. One approach to understanding how the hippocampus processes information is to examine how hippocampal cell activity corresponds to environmental experience. Hippocampal pyramidal cells can alter their spatial tuning (re‐map) in response to changes in task demands. The degree to which this re‐mapping is related to contextual/episodic information or to changes in spatial navigation/trajectories is unclear. The current study was designed to examine cell activity under two conditions that differed in contextual information without alterations in the goal‐directed trajectories taken by the animals. Adult and aged rats were trained to do an alternation task on a fixed pathway [ J. A. Oler et al. (2005)Neuroscience, 131, 1–12]. The animals ran this pathway during either ‘safe’ or ‘unsafe’ (a tone indicating a shock region) trials, with hesitation during ‘unsafe’ trials providing a clear behavioral measure of discrimination between these two conditions. Relatively few place cells displayed re‐mapping between the two conditions. We propose that the principle source of re‐mapping in the dorsal hippocampus is changes in the animal’s trajectories rather than behavioral context. Possible reasons why so few cells responded to the change in context are discussed.
Persistent Rule-Following in the Face of Reversed Reinforcement Contingencies: The Differential Impact of Direct Versus Derived Rules

Rule-governed behavior and its role in generating insensitivity to direct contingencies of reinforcement have been implicated in human psychological suffering. In addition, the human capacity to engage in derived relational responding has also been used to explain specific human maladaptive behaviors, such as irrational fears. To date, however, very little research has attempted to integrate research on contingency insensitivity and derived relations. The current work sought to fill this gap. Across two experiments, participants received either a direct rule (Direct Rule Condition) or a rule that involved a novel derived relational response (Derived Rule Condition). Provision of a direct rule resulted in more persistent rule-following in the face of competing contingencies, but only when the opportunity to follow the reinforced rule beforehand was relatively protracted. Furthermore, only in the Direct Rule Condition were there significant correlations between rule-compliance and stress. A post hoc interpretation of the findings is provided.