Miracle-dz/UniFAR-FTUs huggingface dataset:
Using virtual load/store queues (VLSQs) to reduce the negative effects of reordered memory instructions

The use of large instruction windows coupled with aggressive out-of-order and prefetching capabilities has provided significant improvements in processor performance. In this paper, we quantify the effects of increased out-of-order aggressiveness on a processor's memory ordering/consistency model as well as an application's cache behavior. We observe that increasing reorder buffer sizes cause less than one third of issued memory instructions to be executed in actual program order. We show that increasing the reorder buffer size from 80 to 512 entries results in an increase in the frequency of memory traps by a factor of six and an increase in total execution overhead by 10-40%. Additionally, we observe that the reordering of memory instructions increases the L1 data cache accesses by 10-60% and the L1 data cache misses by 10-20%. These findings reveal that increased out-of-order capability can waste energy in two ways. First, re-fetching and re-executing instructions flushed due to traps require the fetch, map, and execution units to dissipate energy on work that has already been done before. Second, an increase in the number of cache accesses and cache misses needlessly dissipates energy. Both these side effects can be related to the reordering of memory instructions. Thus, to avoid wasting both energy and performance, we propose a virtual load/store queue (VLSQ) within the existing physical load/store queue. The VLSQ reduces the reordering of memory instructions by limiting the number of memory instructions visible to the select and issue logic. We show that VLSQs can reduce trap overhead, cache accesses, and cache misses by as much as 45%, 50%, and 15% respectively when compared to traditional load/store queues. We observe that these reductions yield net power savings of 10-50% with degradation in performance by 1-5%.
Discriminating between Mandarin Chinese and Swiss-German varieties using adaptive language models

This paper describes the language identification systems used by the SUKI team in the Discriminating between the Mainland and Taiwan variation of Mandarin Chinese (DMT) and the German Dialect Identification (GDI) shared tasks which were held as part of the third VarDial Evaluation Campaign. The DMT shared task included two separate tracks, one for the simplified Chinese script and one for the traditional Chinese script. We submitted three runs on both tracks of the DMT task as well as on the GDI task. We won the traditional Chinese track using Naive Bayes with language model adaptation, came second on GDI with an adaptive version of the HeLI 2.0 method, and third on the simplified Chinese track using again the adaptive Naive Bayes.
Measuring Vegetation Phenology with Near-Surface Remote Sensing in a Temperate Deciduous Forest: Effects of Sensor Type and Deployment

Near-surface remote sensing is an effective tool for in situ monitoring of canopy phenology, but the uncertainties involved in sensor-types and their deployments are rarely explored. We comprehensively compared three types of sensor (i.e., digital camera, spectroradiometer, and routine radiometer) at different inclination- and azimuth-angles in monitoring canopy phenology of a temperate deciduous forest in Northeast China for three years. The results showed that the greater contribution of understory advanced the middle of spring (MOS) for large inclination-angle of camera and spectroradiometer. The length of growing season estimated by camera from the east direction extended 11 d than that from the north direction in 2015 due to the spatial heterogeneity, but there was no significant difference in 2016 and 2018.The difference infield of view of sensors caused the MOS and the middle of fall, estimated by camera, to lag a week behind those by spectroradiometer and routine radiometer. Overall, the effect of azimuth-angle was greater than that of inclination-angle or sensor-type. Our assessments of the sensor types and their deployments are critical for the long-term accurate monitoring of phenology at the site scale and the regional/global-integration of canopy phenology data.
Gender, Vertical Height and Horizontal Distance Effects on Single-Leg Landing Kinematics: Implications for Risk of non-contact ACL Injury

There is a lack of studies investigating gender differences in whole-body kinematics during single-leg landings from increasing vertical heights and horizontal distances. This study determined the main effects and interactions of gender, vertical height, and horizontal distance on whole-body joint kinematics during single-leg landings, and established whether these findings could explain the gender disparity in non-contact anterior cruciate ligament (ACL) injury rate. Recreationally active males (n=6) and females (n=6) performed single-leg landings from a takeoff deck of vertical height of 20, 40, and 60 cm placed at a horizontal distance of 30, 50 and 70 cm from the edge of a force platform, while 3D kinematics and kinetics were simultaneously measured. It was determined that peak vertical ground reaction force (VGRF) and the ankle flexion angle exhibited significant gender differences (p=0.028, partial η2=0.40 and p=0.035, partial η2=0.37, respectively). Peak VGRF was significantly correlated to the ankle flexion angle (r= -0.59, p=0.04), hip flexion angle (r= -0.74, p=0.006), and trunk flexion angle (r= -0.59, p=0.045). Peak posterior ground reaction force (PGRF) was significantly correlated to the ankle flexion angle (r= -0.56, p=0.035), while peak knee abduction moment was significantly correlated to the knee flexion angle (r= -0.64, p=0.03). Rearfoot landings may explain the higher ACL injury rate among females. Higher plantar-flexed ankle, hip, and trunk flexion angles were associated with lower peak ground reaction forces, while higher knee flexion angle was associated with lower peak knee abduction moment, and these kinematics implicate reduced risk of non-contact ACL injury.
Quantum Correlations in Systems of Indistinguishable Particles

We discuss quantum correlations in systems of indistinguishable particles in relation to entanglement in composite quantum systems consisting of well separated subsystems. Our studies are motivated by recent experiments and theoretical investigations on quantum dots and neutral atoms in microtraps as tools for quantum information processing. We present analogies between distinguishable particles, bosons, and fermions in low-dimensional Hilbert spaces. We introduce the notion of Slater rank for pure states of pairs of fermions and bosons in analogy to the Schmidt rank for pairs of distinguishable particles. This concept is generalized to mixed states and provides a correlation measure for indistinguishable particles. Then we generalize these notions to pure fermionic and bosonic states in higher-dimensional Hilbert spaces and also to the multi-particle case. We review the results on quantum correlations in mixed fermionic states and discuss the concept of fermionic Slater witnesses. Then the theory of quantum correlations in mixed bosonic states and of bosonic Slater witnesses is formulated. In both cases we provide methods of constructing optimal Slater witnesses that detect the degree of quantum correlations in mixed fermionic and bosonic states.
Toward Rational Planning and Replanning Rational Reason Maintenance, Reasoning Economies, and Qualitative Preferences

Efficiency dictates that plans for large-scale distributed activities be revised incrementally, with parts of plans being revised only if the expected utility of identifying and revising the subplans improves on the expected utility of using the original plan. The problems of identifying and reconsidering the subplans affected by changed circumstances or goals are closely related to the problems of revising beliefs as new or changed information is gained. But traditional techniques of reason maintenance—the standard method for belief revision—choose revisions arbitrarily and enforce global notions of consistency and groundedness which may mean reconsidering all beliefs or plan elements at each step. To address these problems, we developed (1) revision methods aimed at revising only those beliefs and plans worth revising, and tolerating incoherence and ungroundedness when these are judged less detrimental than a costly revision effort, (2) an artificial market economy in planning and revision tasks for arriving at overall judgments of worth, and (3) a representation for qualitative preferences that permits capture of common forms of dominance information.
Glycoengineered Monoclonal Antibodies with Homogeneous Glycan (M3, G0, G2, and A2) Using a Chemoenzymatic Approach Have Different Affinities for FcγRIIIa and Variable Antibody-Dependent Cellular Cytotoxicity Activities

Many therapeutic antibodies have been developed, and IgG antibodies have been extensively generated in various cell expression systems. IgG antibodies contain N-glycans at the constant region of the heavy chain (Fc domain), and their N-glycosylation patterns differ during various processes or among cell expression systems. The Fc N-glycan can modulate the effector functions of IgG antibodies, such as antibody-dependent cellular cytotoxicity (ADCC) and complement dependent cytotoxicity (CDC). To control Fc N-glycans, we performed a rearrangement of Fc N-glycans from a heterogeneous N-glycosylation pattern to homogeneous N-glycans using chemoenzymatic approaches with two types of endo-β-N-acetyl glucosaminidases (ENG’ases), one that works as a hydrolase to cleave all heterogeneous N-glycans, another that is used as a glycosynthase to generate homogeneous N-glycans. As starting materials, we used an anti-Her2 antibody produced in transgenic silkworm cocoon, which consists of non-fucosylated pauci-mannose type (Man2-3GlcNAc2), high-mannose type (Man4-9GlcNAc2), and complex type (Man3GlcNAc3-4) N-glycans. As a result of the cleavage of several ENG’ases (endoS, endoM, endoD, endoH, and endoLL), the heterogeneous glycans on antibodies were fully transformed into homogeneous-GlcNAc by a combination of endoS, endoD, and endoLL. Next, the desired N-glycans (M3; Man3GlcNAc1, G0; GlcNAc2Man3GlcNAc1, G2; Gal2GlcNAc2Man3GlcNAc1, A2; NeuAc2Gal2GlcNAc2Man3GlcNAc1) were transferred from the corresponding oxazolines to the GlcNAc residue on the intact anti-Her2 antibody with an ENG’ase mutant (endoS-D233Q), and the glycoengineered anti-Her2 antibody was obtained. The binding assay of anti-Her2 antibody with homogenous N-glycans with FcγRIIIa-V158 showed that the glycoform influenced the affinity for FcγRIIIa-V158. In addition, the ADCC assay for the glycoengineered anti-Her2 antibody (mAb-M3, mAb-G0, mAb-G2, and mAb-A2) was performed using SKBR-3 and BT-474 as target cells, and revealed that the glycoform influenced ADCC activity.
Novel Reassortant Highly Pathogenic H5N2 Avian Influenza Viruses in Poultry in China

There has been multiple evidence that domestic poultry may act as a vessel for the generation of novel influenza A viruses. In this study, we have analyzed the evolution and pathogenicity of 4 H5N2 avian influenza viruses isolated from apparently healthy poultry from H5N1 virus endemic areas in China. Phylogenetic analysis revealed that two of these viruses, A/duck/Eastern China/1111/2011 (DK/EC/1111/11) and A/goose/Eastern China/1112/2011 (GS/EC/1112/11) were derived from reassortment events in which clade 2.3. 4 highly pathogenic avian influenza (HPAI) H5N1 viruses acquired novel neuraminidase and nonstructural protein genes. Another two isolates, A/chicken/Hebei/1102/2010 (CK/HB/1102/10) and A/duck/Hebei/0908/2009 (DK/HB/0908/09), possess hemagglutinin (HA) gene belong to clade 7 H5 viruses and other genes from endemic H9N2 viruses, or from viruses of various subtypes of the natural gene pool. All of these H5N2 isolates bear characteristic sequences of HPAI virus at the cleavage site of HA, and animal experiments indicated that all of these viruses but DK/HB/0908/09 is highly pathogenic to chickens. In particular, DK/EC/1111/11 and GS/EC/1112/11 are also highly pathogenic to ducks and moderately pathogenic to mice. All of these 4 viruses were able to replicate in domestic ducks and mice without prior adaptation. The emergence of these novel H5N2 viruses adds more evidence for the active evolution of H5 viruses in Asia. The maintenance of the highly pathogenic phenotype of some of these viruses even after reassortment with a new NA subtypes, their ability to replicate and transmit in domestic poultry, and the pathogenicity in the mammalian mouse model, highlight the potential threat posed by these viruses to both veterinary and public health.
Locus of Control: The Mediation Effect between Emotional Stability and Pro-Environmental Behavior

Locus of control is a crucial factor in pro-environmental behavior. However, studies on pro-environmental behavior investigating the predisposing factors of internal locus of control are limited. Therefore, the objective of this study further explored the predisposing factors of locus of control and revealed that emotional stability may be a predisposing factor for internal locus of control and pro-environmental behavior. A questionnaire survey was conducted in Taiwan (n = 473) and the responses were explored using structural equation modeling path analysis. The results revealed that emotional stability can promote pro-environmental behavior through the mediation effect of internal locus of control, indicating that emotional stability is a predisposing factor for locus of control-generated pro-environmental behavior. Thus, the study results indicated that people with higher emotional stability and a stronger internal locus of control are more likely to engage in pro-environmental behavior. Hence, to promote pro-environmental behavior through environmental protection education, people’s self-control awareness must be strengthened to enable them to remain calm and peaceful.
Transmodal Sensorimotor Networks during Action Observation in Professional Pianists

Audiovisual perception and imitation are essential for musical learning and skill acquisition. We compared professional pianists to musically naive controls with fMRI while observing piano playing fingerhand movements and serial fingerthumb opposition movements both with and without synchronous piano sound. Pianists showed stronger activations within a fronto-parieto-temporal network while observing piano playing compared to controls and contrasted to perception of serial fingerthumb opposition movements. Observation of silent piano playing additionally recruited auditory areas in pianists. Perception of piano sounds coupled with serial fingerthumb opposition movements evoked increased activation within the sensorimotor network. This indicates specialization of multimodal auditory sensorimotor systems within a fronto-parieto-temporal network by professional musical training. Musical language, which is acquired by observation and imitation, seems to be tightly coupled to this network in accord with an observation execution system linking visual and auditory perception to motor performance.
Rapid Alteration of Tau in Oligodendrocytes After Focal Ischemic Injury in the Rat: Involvement of Free Radicals

Glial inclusions containing the microtubule-associated protein tau are present in a variety of chronic neurodegenerative conditions. We now report a rapid and time-dependent increase of tau immunoreactivity within oligodendrocytes after focal cerebral ischemia in the rat. The number of tau positive oligodendrocytes in the ipsilateral subcortical white matter increased six- to eightfold by 40 minutes after permanent middle cerebral artery occlusion (MCAO). Tau was detected using antibodies that label both the N- and C-terminal of the protein, suggesting accumulation of full-length protein within these cells. Pretreatment with the spin trap agent α-phenyl-tert-butyl-nitrone (PBN)(100mg/kg) reduced the number of tau-positive oligodendrocytes by 55% in the subcortical white matter of the ischemic hemisphere compared with untreated animals at 40 minutes after MCAO. In contrast, pretreatment with glutamate receptor antagonists MK-801 (0.5 mg/kg) or 2,3-dihydroxy-6-nitro-7-sulpfamoylbenzo(f)quinoxaline (NBQX) (2 × 30 mg/kg), failed to reduce the number of tau-positive oligodendrocytes after 40 minutes of ischemia. The results indicate that oligodendrocytes respond rapidly to an ischemic challenge and that free radical-mediated mechanisms are involved in the cascade leading to increased tau immunoreactivity.
Heat Transfer of Iron Oxide Nanofluid in a Double Pipe Heat Exchanger

Reza Aghayari, Shabnam Jahanizadeh , Jafar Baghbani Arani, Heydar Maddah,Mahshid pourali and Amir Hoshang Khalaj Sama Technical and Vocatinal Training College,Islamic Azad University, Saveh Branch, Saveh,Iran. Young Researchers Club, Islamic Azad University, Arak, Iran. Department of chemical Engineering ,Faculty of Engineering,Arak University, Arak, Iran. Chemical Engineering Department, Kashan University, Kashan, Iran. Department of Chemistry, Sciences Faculty, Arak Branch, Islamic Azad University, Arak, Iran. Department of Chemical Engineering, Azad shahr Branch, Islamic Azad University, Azad shahr, Iran. Saveh Vocational School, Iran.
Synapses as Therapeutic Targets for Autism Spectrum Disorders: An International Symposium Held in Pavia on July 4th, 2014

New progresses into the molecular and cellular mechanisms of autism spectrum disorders (ASDs) have been discussed in 1 day international symposium held in Pavia (Italy) on July 4th, 2014 entitled “synapses as therapeutic targets for autism spectrum disorders” (satellite of the FENS Forum for Neuroscience, Milan, 2014). In particular, world experts in the field have highlighted how animal models of ASDs have greatly advanced our understanding of the molecular pathways involved in synaptic dysfunction leading sometimes to “synaptic clinical trials” in children.
Genetic progress of grain quality of flooded-irrigated rice cultivars in the state of Rio Grande do Sul, Brazil

The objective of this work was to determine the genetic progress of grain quality attributes of flooded irrigated rice ( Oryza sativa ) cultivars in the state of Rio Grande do Sul, Brazil, between 1972 and 2016. The genetic estimates followed an approach based on the comparative analysis of 25 cultivars released by Embrapa’s breeding program over this period. The experiment was implemented in four producing regions of the state of Rio Grande do Sul: Sul, Campanha, Planicie Costeira Interna, and Planicie Costeira Externa. The following significant genetic gains were observed: 0.20% per year, for percentage of whole grains after processing; -1.38% per year, for percentage of chalky kernels and white-core grains; -0.77% per year, for total chalky area; -0.08% per year, for total whiteness; and -0.82% per year, for non-vitreous grain whiteness. Most cultivars released have high amylose content and a low gelatinization temperature. Therefore, the breeding program presented significant annual genetic progresses between 1972 and 2016 for the main attributes of grain quality, and made cultivars available according to the national demand for grain quality in the several segments of the rice production industry.
The Characteristics of Air Pollutants during Two Distinct Episodes of Fireworks Burning in a Valley City of North China

Background The elevation and dissipation of pollutants after the ignition of fireworks in different functional areas of a valley city were investigated. Methods The Air Quality Index (AQI) as well as inter-day and intra-day concentrations of various air pollutants (PM10, PM2.5, SO2, NO2, CO, O3) were measured during two episodes that took place during Chinese New Year festivities. Results For the special terrain of Jinan, the mean concentrations of pollutants increased sharply within 2–4 h of the firework displays, and concentrations were 4–6 times higher than the usual levels. It took 2–3 d for the pollutants to dissipate to background levels. Compared to Preliminary Eve (more fireworks are ignited on New Year’s Eve, but the amounts of other human activities are also lesser), the primary pollutants PM2.5, PM10, and CO reached higher concentrations on New Year’s Eve, and the highest concentrations of these pollutants were detected in living quarters. All areas suffered from serious pollution problems on New Year’s Eve (rural = urban for PM10, but rural > urban for PM2.5). However, SO2 and NO2 levels were 20%–60% lower in living quarters and industrial areas compared to the levels in these same areas on Preliminary Eve. In contrast to the other pollutants, O3 concentrations fell instead of rising with the firework displays. Conclusion Interactions between firework displays and other human activities caused different change trends of pollutants. PM2.5 and PM10 were the main pollutants, and the rural living quarter had some of the highest pollution levels.
Covariance algebra of a partial dynamical system

A pair (X, α) is a partial dynamical system if X is a compact topological space and α: Δ→ X is a continuous mapping such that Δ is open. Additionally we assume here that Δ is closed and α(Δ) is open. Such systems arise naturally while dealing with commutative C*-dynamical systems.
Bioavailability of Nutrients and Other Bioactive Components from Dietary Supplements Case Study : Folate Bioavailability 1 , 2

Folate nutritional status depends on intake from food and supplements as well as on the bioavailability of the various ingested forms of this vitamin. Although many advances in the understanding of folate bioavailability have occurred in recent years, many areas of uncertainty remain, especially with respect to naturally occurring dietary folate. This review includes a summary of factors that affect folate absorption and utilization, currently used and promising methods suitable for the assessment of bioavailability, significant findings on which current understanding is based and research needs. J. Nutr. 131: 1376S–1382S, 2001.
Predictors of prostate volume reduction following neoadjuvant cytoreductive androgen suppression

Purpose Limited duration cytoreductive neoadjuvant hormonal therapy (NHT) is used prior to definitive radiotherapeutic management of prostate cancer to decrease prostate volume. The purpose of this study is to examine the effect of NHT on prostate volume before permanent prostate brachytherapy (PPB), and determine associated predictive factors. Material and methods Between June 1998 and April 2012, a total of 1,110 patients underwent PPB and 207 patients underwent NHT. Of these, 189 (91.3%) underwent detailed planimetric transrectal ultrasound before and after NHT prior to PPB. Regression analysis was used to assess predictors of absolute and percentage change in prostate volume after NHT. Results The median duration of NHT was 4.9 months with inter quartile range (IQR), 4.2-6.6 months. Prostate-specific antigen (PSA) reduced by a median of 97% following NHT. The mean prostate volume before NHT was 62.5 ± 22.1 cm3 (IQR: 46-76 cm3), and after NHT, it was 37.0 ± 14.5 cm3 (IQR: 29-47 cm3). The mean prostate volume reduction was 23.4 cm3 (35.9%). Absolute prostate volume reduction was positively correlated with initial volume and inversely correlated with T-stage, Gleason score, and NCCN risk group. In multivariate regression analyses, initial prostate volume (p < 0.001) remained as a significant predictor of absolute and percent prostate volume reduction. Total androgen suppression was associated with greater percent prostate volume reduction than luteinizing hormone releasing hormone agonist (LHRHa) alone (p = 0.001). Conclusions Prostate volume decreased by approximately one third after 4.9 months of NHT, with total androgen suppression found to be more efficacious in maximizing cytoreduction than LHRHa alone. Initial prostate volume is the greatest predictor for prostate volume reduction.