Miracle-dz/UniFAR-FTUs huggingface dataset:
iPSC‐derived mesenchymal stem cells exert SCF‐dependent recovery of cigarette smoke‐induced apoptosis/proliferation imbalance in airway cells

Mesenchymal stem cells (MSCs) have emerged as a potential cell‐based therapy for pulmonary emphysema in animal models. Our previous study demonstrated that human induced pluripotent stem cell–derived MSCs (iPSC‐MSCs) were superior over bone marrow–derived MSCs (BM‐MSCs) in attenuating cigarette smoke (CS)‐induced airspace enlargement possibly through mitochondrial transfer. This study further investigated the effects of iPSC‐MSCs on inflammation, apoptosis, and proliferation in a CS‐exposed rat model and examined the effects of the secreted paracrine factor from MSCs as another possible mechanism in an in vitro model of bronchial epithelial cells. Rats were exposed to 4% CS for 1 hr daily for 56 days. At days 29 and 43, human iPSC‐MSCs or BM‐MSCs were administered intravenously. We observed significant attenuation of CS‐induced elevation of circulating 8‐isoprostane and cytokine‐induced neutrophil chemoattractant‐1 after iPSC‐MSC treatment. In line, a superior capacity of iPSC‐MSCs was also observed in ameliorating CS‐induced infiltration of macrophages and neutrophils and apoptosis/proliferation imbalance in lung sections over BM‐MSCs. In support, the conditioned medium (CdM) from iPSC‐MSCs ameliorated CS medium‐induced apoptosis/proliferation imbalance of bronchial epithelial cells in vitro. Conditioned medium from iPSC‐MSCs contained higher level of stem cell factor (SCF) than that from BM‐MSCs. Deprivation of SCF from iPSC‐MSC‐derived CdM led to a reduction in anti‐apoptotic and pro‐proliferative capacity. Taken together, our data suggest that iPSC‐MSCs may possess anti‐apoptotic/pro‐proliferative capacity in the in vivo and in vitro models of CS‐induced airway cell injury partly through paracrine secretion of SCF.
Early Cambrian origin of modern food webs: evidence from predator arrow worms

Although palaeontological evidence from exceptional biota demonstrates the existence of diverse marine communities in the Early Cambrian (approx. 540–520 Myr ago), little is known concerning the functioning of the marine ecosystem, especially its trophic structure and the full range of ecological niches colonized by the fauna. The presence of a diverse zooplankton in Early Cambrian oceans is still an open issue. Here we provide compelling evidence that chaetognaths, an important element of modern zooplankton, were present in the Early Cambrian Chengjiang biota with morphologies almost identical to Recent forms. New information obtained from the lowermost Cambrian of China added to previous studies provide convincing evidence that protoconodont-bearing animals also belonged to chaetognaths. Chaetognaths were probably widespread and diverse in the earliest Cambrian. The obvious raptorial function of their circumoral apparatuses (grasping spines) places them among the earliest active predator metazoans. Morphology, body ratios and distribution suggest that the ancestral chaetognaths were planktonic with possible ecological preferences for hyperbenthic niches close to the sea bottom. Our results point to the early introduction of prey–predator relationships into the pelagic realm, and to the increase of trophic complexity (three-level structure) during the Precambrian–Cambrian transition, thus laying the foundations of present-day marine food chains.
Psychiatric consequences of road traffic accidents.

OBJECTIVE--To determine the psychiatric consequences of being a road traffic accident victim. DESIGN--Follow up study of road accident victims for up to one year. SETTING--Emergency department of the John Radcliffe Hospital, Oxford. SUBJECTS--188 consecutive road accident victims aged 18-70 with multiple injuries (motorcycle or car) or whiplash neck injury, who had not been unconscious for more than 15 minutes, and who lived in the catchment area. MAIN OUTCOME MEASURES--Present state examination "caseness"; post-traumatic stress disorder and travel anxiety; effects on driving and on being a passenger. RESULTS--Acute, moderately severe emotional distress was common. Almost one fifth of subjects, however, suffered from an acute stress syndrome characterised by mood disturbance and horrific memories of the accident. Anxiety and depression usually improved over the 12 months, though one tenth of patients had mood disorders at one year. In addition, specific post-traumatic symptoms were common. Post-traumatic stress disorder occurred during follow up in one tenth of patients, and phobic travel anxiety as a driver or passenger was more common and frequently disabling. Emotional disorder was associated with having pre-accident psychological or social problems and, in patients with multiple injuries, continuing medical complications. Post-traumatic syndromes were not associated with a neurotic predisposition but were strongly associated with horrific memories of the accident. They did not occur in subjects who had been briefly unconscious and were amnesic for the accident. Mental state at three months was highly predictive of mental state at one year. CONCLUSIONS--Psychiatric symptoms and disorder are frequent after major and less severe road accident injury. Post-traumatic symptoms are common and disabling. Early information and advice might reduce psychological distress and travel anxiety and contribute to road safety and assessing "nervous shock. "
Nanodiamonds do not provide unique evidence for a Younger Dryas impact

Microstructural, δ13C isotope and C/N ratio investigations were conducted on excavated material from the black Younger Dryas boundary in Lommel, Belgium, aiming for a characterisation of the carbon content and structures. Cubic diamond nanoparticles are found in large numbers. The larger ones with diameters around or above 10 nm often exhibit single or multiple twins. The smaller ones around 5 nm in diameter are mostly defect-free. Also larger flake-like particles, around 100 nm in lateral dimension, with a cubic diamond structure are observed as well as large carbon onion structures. The combination of these characteristics does not yield unique evidence for an exogenic impact related to the investigated layer.
Analyses of Current-Generating Mechanisms of Shewanella loihica PV-4 and Shewanella oneidensis MR-1 in Microbial Fuel Cells

ABSTRACT Although members of the genus Shewanella have common features (e.g., the presence of decaheme c-type cytochromes [c-cyts]), they are widely variable in genetic and physiological features. The present study compared the current-generating ability of S. loihica PV-4 in microbial fuel cells (MFCs) with that of well-characterized S. oneidensis MR-1 and examined the roles of c-cyts in extracellular electron transfer. We found that strains PV-4 and MR-1 exhibited notable differences in current-generating mechanisms. While the MR-1 MFCs maintained a constant current density over time, the PV-4 MFCs continued to increase in current density and finally surpassed the MR-1 MFCs. Coulombic efficiencies reached 26% in the PV-4 MFC but 16% in the MR-1 MFCs. Although both organisms produced quinone-like compounds, anode exchange experiments showed that anode-attached cells of PV-4 produced sevenfold more current than planktonic cells in the same chamber, while planktonic cells of MR-1 produced twice the current of the anode-attached cells. Examination of the genome sequence indicated that PV-4 has more c-cyt genes in the metal reductase-containing locus than MR-1. Mutational analysis revealed that PV-4 relied predominantly on a homologue of the decaheme c-cyt MtrC in MR-1 for current generation, even though it also possesses two homologues of the decaheme c-cyt OmcA in MR-1. These results suggest that current generation in a PV-4 MFC is in large part accomplished by anode-attached cells, in which the MtrC homologue constitutes the main path of electrons toward the anode.
Herbal medicine use among patients with chronic diseases

Aim: Complementary and alternative medicine (CAM) is commonly used all over the world, and herbal medicines are the most preferred ways of CAM. The aim of this study was to determine the frequency of herbal medicine use among patients with chronic diseases. Methodology: A cross-sectional descriptive study was conducted from April 2014 to December 2014 among patients who had been diagnosed with diabetes mellitus (DM), hypertension (HT), and hyperlipidemia (HL) in Family Medicine Department of Dışkapı Yıldırım Beyazıt Training and Research Hospital, in Ankara. A questionnaire about herbal drug use was applied by face to face interview to the participants. Results: A total of 217 patients were included in this study. The mean age of the participants was 56.6 ± 9.7 years (55 male and 162 female). The rate of herbal medicine use was 29%. Herbal medicine use among female gender was significantly higher (P = 0.040). Conventional medication use was found to be lower among herbal medicine consumers. There was no relationship between herbal medicine use and type of chronic disease, living area, and occupation or education level. Most frequently used herbs were lemon (39.6%) and garlic (11.1%) for HT, cinnamon (12.7%) for DM, and walnut (6.3%) for HL. Conclusions: In this study, herbal medicine use was found to be higher among patients who had been diagnosed with chronic diseases. Therefore, physicians should be aware of herbal medicine usage of their patients and inform them about the effectivity and side effects of herbal medicines.
When DLB, PD, and PSP masquerade as MSA

Objective: To determine ways to improve diagnostic accuracy of multiple system atrophy (MSA), we assessed the diagnostic process in patients who came to autopsy with antemortem diagnosis of MSA by comparing clinical and pathologic features between those who proved to have MSA and those who did not. We focus on likely explanations for misdiagnosis. Methods: This is a retrospective review of 134 consecutive patients with an antemortem clinical diagnosis of MSA who came to autopsy with neuropathologic evaluation of the brain. Of the 134 patients, 125 had adequate medical records for review. Clinical and pathologic features were compared between patients with autopsy-confirmed MSA and those with other pathologic diagnoses, including dementia with Lewy bodies (DLB), Parkinson disease (PD), and progressive supranuclear palsy (PSP). Results: Of the 134 patients with clinically diagnosed MSA, 83 (62%) had the correct diagnosis at autopsy. Pathologically confirmed DLB was the most common misdiagnosis, followed by PSP and PD. Despite meeting pathologic criteria for intermediate to high likelihood of DLB, several patients with DLB did not have dementia and none had significant Alzheimer-type pathology. Autonomic failure was the leading cause of misdiagnosis in DLB and PD, and cerebellar ataxia was the leading cause of misdiagnosis in PSP. Conclusions: The diagnostic accuracy for MSA was suboptimal in this autopsy study. Pathologically confirmed DLB, PD, and PSP were the most common diseases to masquerade as MSA. This has significant implications not only for patient care, but also for research studies in MSA cases that do not have pathologic confirmation.
GAP-43 Is Critical for Normal Development of the Serotonergic Innervation in Forebrain

Serotonergic (5-HT) axons from the raphe nuclei are among the earliest afferents to innervate the developing forebrain. The present study examined whether GAP-43, a growth-associated protein expressed on growing 5-HT axons, is necessary for normal 5-HT axonal outgrowth and terminal arborization during the perinatal period. We found a nearly complete failure of 5-HT immunoreactive axons to innervate the cortex and hippocampus in GAP-43–null (GAP43−/−) mice. Abnormal ingrowth of 5-HT axons was apparent on postnatal day 0 (P0); quantitative analysis of P7 brains revealed significant reductions in the density of 5-HT axons in the cortex and hippocampus of GAP43−/− mice relative to wild-type (WT) controls. In contrast, 5-HT axon density was normal in the striatum, septum, and amygdala and dramatically higher than normal in the thalamus of GAP43−/− mice. Concentrations of serotonin and its metabolite, 5-hydroxyindolacetic acid, and norepinephrine were decreased markedly in the anterior and posterior cerebrum but increased in the brainstem of GAP43−/− mice. Cell loss could not account for these abnormalities, because unbiased stereological analysis showed no significant difference in the number of 5-HT dorsal raphe neurons in P7 GAP43−/− versus WT mice. The aberrant 5-HT innervation pattern persisted at P21, indicating a long-term alteration of 5-HT projections to forebrain in the absence of GAP-43. In heterozygotes, the density and morphology of 5-HT axons was intermediate between WT and homozygous GAP43−/− mice. These results suggest that GAP-43 is a key regulator in normal pathfinding and arborization of 5-HT axons during early brain development.
Identifying bilingual Multi-Word Expressions for Statistical Machine Translation

MultiWord Expressions (MWEs) repesent a key issue for numerous applications in Natural Language Processing (NLP) especially for Machine Translation (MT). In this paper, we describe a strategy for detecting translation pairs of MWEs in a French-English parallel corpus. In addition we introduce three methods aiming to integrate extracted bilingual MWE S in M OSES, a phrase based Statistical Machine Translation (SMT) system. We experimentally show that these textual units can improve translation quality.
Distinct signaling pathways are involved in hypoxia‐ and IL‐1‐induced VEGF expression in human articular chondrocytes

Recent data suggest that vascular endothelial growth factor (VEGF) is involved in the pathogenesis of osteoarthritis (OA). Cartilage is an avascular tissue, leading to a low cartilage O2 level. Thus, in a variety of pathologic or physiologic conditions, VEGF is partly regulated by hypoxic stress. The implications of hypoxia for VEGF expression by OA chondrocytes, however, are not known. We investigated the regulatory system of VEGF in OA chondrocytes under hypoxic conditions. Chondrocytes were obtained from articular cartilage of patients with OA. Cells were cultured and then incubated under hypoxic (95% N2, 5% CO2) or normoxic conditions, with or without interleukin (IL)‐1 (10 ng/mL) stimulation. The mitogen activated protein kinase (MAPK) inhibitors were also used. VEGF levels in the culture supernatants were measured using an enzyme‐linked immunosorbent assay. Western blot analysis was used to examine the expression of hypoxia inducible factor (HIF)‐1α. Hypoxia significantly increased VEGF levels (p < 0.05). Hypoxia‐induced VEGF secretion was abolished by p38MAPK inhibitor, but not by JNK inhibitor. In contrast, IL‐1‐induced VEGF secretion was blocked by JNK inhibitor, and not by p38MAPK inhibitor. Both hypoxia and IL‐1‐induced HIF‐1α were attenuated by p38 MAPK and JNK inhibitors. We demonstrate that hypoxia and IL‐1 induce VEGF production in chondrocytes through distinct MAPK signaling pathways, indicating that VEGF is induced in a HIF‐1‐dependent or ‐independent manner in chondrocytes. © 2006 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 24:1544–1554, 2006
Hypothermic ante situm Resection in Tumors of the Hepatocaval Confluence

Primary liver malignancies together with metastatic liver tumors are among the most common tumors in human. The best available treatment option for these diseases is surgical resection. One major parameter which had been considered as contraindication for liver resection owing to technical difficulties in achieving tumor-free margins was the involvement of the hepatocaval confluence. To overcome this problem, several techniques including hypothermic in situ, ante situm and ex situ liver resection have been introduced. The common basis for these liver resections is the total vascular exclusion of the liver, and perfusion of the organ by preservation solution under hypothermic conditions. The major indications for the ante situm liver resection are tumors in the liver that are either unresectable or inadequately resectable by conventional surgery because they involve the venous confluence and/or the retrohepatic vena cava, or are in close proximity to them. This technique is a realistic option to achieve surgical cure or substantial gain of life time with quality of life in otherwise unresectable tumors of the liver. Due to fewer anastomoses, the ante situm approach is easier and safer than the ex situ approach, with an acceptable morbidity and mortality rate. Patient selection is of utmost importance to achieve a good outcome. To minimize the postoperative morbidities and mortality, this procedure requires a multidisciplinary approach and should be performed in experienced centers with a high case volume of hepatobiliary surgeries.
Implementation of Pipelined FastICA on FPGA for Real-Time Blind Source Separation

Fast independent component analysis (FastICA) algorithm separates the independent sources from their mixtures by measuring non-Gaussian. FastICA is a common offline method to identify artifact and interference from their mixtures such as electroencephalogram (EEG), magnetoencephalography (MEG), and electrocardiogram (ECG). Therefore, it is valuable to implement FastICA for real-time signal processing. In this paper, the FastICA algorithm is implemented in a field-programmable gate array (FPGA), with the ability of real-time sequential mixed signals processing by the proposed pipelined FastICA architecture. Moreover, in order to increase the numbers precision, the hardware floating-point (FP) arithmetic units had been carried out in the hardware FastICA. In addition, the proposed pipeline FastICA provides the high sampling rate (192 kHz) capability by hand coding the hardware FastICA in hardware description language (HDL). To verify the features of the proposed hardware FastICA, simulations are first performed, then real-time signal processing experimental results are presented using the fabricated platform. Experimental results demonstrate the effectiveness of the presented hardware FastICA as expected.
The 2008 Okuda lecture: Management of hepatocellular carcinoma: From surveillance to molecular targeted therapy

Hepatocellular carcinoma (HCC) is responsible for approximately 600 000–700 000 deaths worldwide. It is highly prevalent in the Asia‐Pacific region and Africa, and is increasing in Western countries. Alpha fetoprotein (AFP) alone is insufficient for HCC screening. A combination with other tumor markers, such as PIVKA‐II and AFP‐L3, and periodical ultrasound surveillance is necessary. Sensitivity of AFP in depicting HCC is highest, followed by PIVKA‐II and AFP‐L3, but the order of the specificity is inverse, AFP‐L3, PIVKA‐II, and AFP. Sonazoid‐enhanced ultrasound (US) is extremely useful to characterize hepatic tumors equal to or more than multidetector row computed tomography (MDCT). Sonazoid‐enhanced US with defect re‐perfusion imaging is a breakthrough technique in the treatment of HCC. Defect re‐perfusion imaging will markedly change the therapeutic strategy for liver cancer. Gd‐EOB‐DTPA‐magnetic resonance imaging is a newly developed imaging technique in the detection and diagnosis of HCC. It is the most sensitive tool in the differentiation of early HCC from dysplastic nodules. Regarding the treatment strategy, there has been no established systemic chemotherapy for advanced HCC, except for Sorafenib. Empirically, intrahepatic arterial infusion chemotherapy using implanted reservoir port is known to be effective in response rate and overall survival for advanced HCC with vascular invasion. Sorafenib in combination with transcatheter arterial chemoembolization or adjuvant use after ablation or resection will significantly prolong the life expectancy if ongoing clinical trials provide positive results. In conclusion, it is expected that readers will gain deeper insight into the latest progress and updated diagnosis and treatment of HCC described in this review.
Minimal Assumptions for Efficient Mercurial Commitments

Mercurial commitments were introduced by Chase et al. [8] and form a key building block for constructing zero-knowledge sets (introduced by Micali, Rabin and Kilian [27]). Unlike regular commitments, which are strictly binding, mercurial commitments allow for certain amount of (limited) freedom. The notion of [8] also required that mercurial commitments should be equivocable given a certain trapdoor, although the notion is interesting even without this condition. While trivially implying regular (trapdoor) commitments, it was not clear from the prior work if the converse was true: Chase et al. [8] gave several constructions of mercurial commitments from various incompatible assumptions, leaving open if they can be built from any (trapdoor) commitment scheme, and, in particular, from any one-way function. We give an affirmative answer to this question, by giving two simple constructions of mercurial commitments from any trapdoor bit commitment scheme. By plugging in various (trapdoor) bit commitment schemes, we get all the efficient constructions from [27, 8], as well as several immediate new constructions. Our results imply that (a) mercurial commitments can be viewed as surprisingly simple variations of regular (trapdoor) commitments (and, thus, can be built from one-way functions and, more efficiently, from a variety of other assumptions); and (b) the existence of zero-knowledge sets is equivalent to the existence of collisionresistant hash functions (moreover, the former can be efficiently built from the latter and trapdoor commitments). Of independent interest, we also give a stronger and yet much simpler definition of mercurial commitments than that of [8] (which is also met by our constructions). Overall, we believe that our results eludicate the notion of mercurial commitments, and better explain the rational following the previous constructions of [27, 8]. ∗This is an independent part of the joint paper with Dario Catalano and Ivan Visconti from TCC’06 [6]. †Department of Computer Science, New York University, 251 Mercer Street, New York, NY 10012, USA. Email: dodis@cs.nyu. edu
Asymptotics of solute dispersion in periodic porous media

The concentration $C( {\bf x},t )$ of a solute in a saturated porous medium is governed by a second-order parabolic equation $\partial C / \partial t = U_0 {\bf b} \cdot \nabla C + \tfrac{1}{2} \sum D_{ij} \partial ^2 C /\partial x_i \partial x_j $. In the case that ${\bf b}$ is periodic and divergence free, and $D_{ij} $ are constants and$( ( D_{ij} ) )$ positive definite, the concentration is asymptotically Gaussian for large times. This article analyzes the dependence of the dispersion matrix ${\bf k}$ of the limiting Gaussian distribution on the velocity parameter $U_0$ and the period “a” It is shown that each coefficient $K_{ii} $ is asymptotically quadratic in $aU_0 $if $b_i \bar - \bar b_j $. has a nonzero component in the null space of ${\bf b} \cdot \nabla $, and asymptotically constant in $aU_0 $if $b_i \bar - \bar b_j $. belongs to the range of ${\bf b}\cdot \nabla$. It is shown in a more general context that ${\bf k}$ depends only on $aU_0 $. An asymptotic expansion of the Cramer–Edgeworth typ.