Miracle-dz/UniFAR-FTUs huggingface dataset:
Nutritional response of growing rats to faba beans (Vicia faba L., minor) and faba bean fractions

The effects of raw faba bean (Vicia faba L., minor) meal (VFM) and its fractions on the growth and nitrogen utilization of rats have been determined in two experiments. Two commercial varieties of VFM were tested, local VFM (409–439 g/kg diet) and Troy VFM (439 g/kg diet). The bean fractions tested were V. faba lectin-depleted protein (VFDP), V. faba lectin (VFL) and V. faba cotyledon residue (VFCR). All diets were supplemented with amino acids to target requirements. Body-weight, body N and lipid contents of rats fed on VFM were reduced significantly in comparison with control rats fed on lactalbumin. This was due, in part, to the lower digestibility of the protein, lipid and dry matter (DM) of VFM diets. As a result, net protein utilization (NPU) and biological value (BV) of faba bean proteins were less than expected. Urine and urea-N outputs of the VFM-fed rats were also elevated in both experiments. Increasing the energy content of local VFM diets led to significantly higher dry body-weight, body N and lipid contents, with the result that the NPU and BV values of the protein also increased. However, the NPU values for VFM-fed rats were still significantly lower than those for the controls in both experiments. In contrast, true N, lipid and DM digestibilities in rats given local VFM were not significantly affected by the difference in the energy content of the diets. The replacement of two-thirds of the lactalbumin in the diet with VFDP (65 g/kg) reduced dry body-weight, N and lipid contents, NPU and BV compared with the control rats, even though N, lipid and DM digestibilities were not significantly different. The nutritional performance of rats fed on lactalbumin-based diets containing 7 g VFL/kg was similar to that of the controls. Similarly, the inclusion of the cotyledon residue (237 g VFCR/kg diet) had no appreciable effect on any of the variables studied. As VFL and VFCR had no antinutritional effects in these rats, it appears that the low nutritional value of VFM for rats (NPU 0.66) results not only from the low digestibility of the bean proteins, but also from disturbances in N metabolism.
Engagement in course development by employers not traditionally involved in Higher Education: student and employer perceptions of its impact

The aim of the research was to improving understanding of employers' engagement in Higher Education and identify its impact. In particular, the review looked at engagement by employers that have not traditionally been involved in Higher Education. The research involved a systematic review that identified research in the UK and synthesised the eight most robust research studies.
Clinical and Pathologic Study of Feline Merkel Cell Carcinoma With Immunohistochemical Characterization of Normal and Neoplastic Merkel Cells

The authors herein describe the morphologic and immunohistochemical features of normal Merkel cells as well as the clinicopathologic findings of Merkel cell carcinoma in cats. Merkel cells were characterized as vacuolated clear cells and were individually located in the epidermal basal layer of all regions examined. Clusters of Merkel cells were often observed adjacent to the sinus hair of the face and carpus. Immunohistochemically, Merkel cells were positive for cytokeratin (CK) 20, CK18, p63, neuron-specific enolase, synaptophysin, and protein gene product 9.5. Merkel cell carcinoma was detected as a solitary cutaneous mass in 3 aged cats (13 to 16 years old). On cytology, large lymphocyte-like cells were observed in all cases. Histologic examinations of surgically resected tumors revealed nests of round cells separated by various amounts of a fibrous stroma. Tumor cells were commonly immunopositive for CK20, CK18, p63, neuron-specific enolase, and synaptophysin, representing the characteristics of normal Merkel cells.
Person–organization fit and employee outcomes: test of a social exchange model

Data obtained from subordinate–supervisor dyads (N = 314) of a large manufacturing company in South Korea were used to test a moderated mediation model of the processes linking person–organization (P–O) fit and employee work attitudes and behaviors. The results revealed that the influence of P–O fit on work attitudes and behaviors was indirect through perceived social exchange with organization. In addition, the relationship between P–O fit and perceived social exchange with organization was moderated by leader–member exchange (LMX) quality. Specifically, a high-quality LMX enhanced the positive effects of P–O fit on perceived social exchange with organization.
Social regulation and diversity management: A comparative study of France, Canada and the UK

Much of the diversity management debate is trapped in a binary opposition between regulation and voluntarism. We argue for an evidence-based approach and illustrate this by offering a context-sensitive overview of workforce diversity debate and practice in three countries: France, Canada and the UK. We use Reynaud’s social regulation theory in order to challenge the assumption that there is a clear separation between regulation and voluntarism. The article unpacks the complexities and ambivalences of regulation of workforce diversity, which is generated by multiple influences.
Assessment of quantitative cortical biomarkers in the developing brain of preterm infants

The cerebral cortex rapidly develops its folding during the second and third trimester of pregnancy. In preterm birth, this growth might be disrupted and influence neurodevelopment. The aim of this work is to extract quantitative biomarkers describing the cortex and evaluate them on a set of preterm infants without brain pathology. For this study, a set of 19 preterm - but otherwise healthy - infants scanned coronally with 3T MRI at the postmenstrual age of 30 weeks were selected. In ten patients (test set), the gray and white matter were manually annotated by an expert on the T2-weighted scans. Manual segmentations were used to extract cortical volume, surface area, thickness, and curvature using voxel-based methods. To compute these biomarkers per region in every patient, a template brain image has been generated by iterative registration and averaging of the scans of the remaining nine patients. This template has been manually divided in eight regions, and is transformed to every test image using elastic registration. In the results, gray and white matter volumes and cortical surface area appear symmetric between hemispheres, but small regional differences are visible. Cortical thickness seems slightly higher in the right parietal lobe than in other regions. The parietal lobes exhibit a higher global curvature, indicating more complex folding compared to other regions. The proposed approach can potentially - together with an automatic segmentation algorithm - be applied as a tool to assist in early diagnosis of abnormalities and prediction of the development of the cognitive abilities of these children.
Analysis of Stakeholder Perceptions of a Clinical Model Involving Co-Teaching and Extended-Field Experiences in an Inclusive Middle-Grades Setting

Abstract A qualitative study of the impact of a school-university partnership in which eight teacher candidates from a two-year graduate program were placed together in a poverty level middle school was conducted. Teacher candidates in this particular program receive a master’s degree, as well as a teaching license in their content area and special education. Using primarily focus group interviews with school leaders, cooperating teachers in special education and content classrooms, and teacher candidates, we wanted to determine the influence of the partnership on all stakeholders. We read transcripts to identify themes and coded by those themes. Later, we tracked the frequency of responses for each theme. We also examined learning gains data for students on Individual Education Plans (IEPs) and English Language Learners (ELLs) in content rooms in which teacher candidates taught, as well as interviewed a small sampling of middle school students. We found overwhelming support for the partnership across all stakeholders. Most frequently stakeholders noted cooperating teachers’ increased ability to meet the needs of students with learning differences in their inclusive classrooms. This research contributes to the literature on the impact of school-university partnerships and co-teaching and on teaching and learning.
Wnt/β-catenin signaling requires interaction of the Dishevelled DEP domain and C terminus with a discontinuous motif in Frizzled

Wnt binding to members of the seven-span transmembrane Frizzled (Fz) receptor family controls essential cell fate decisions and tissue polarity during development and in adulthood. The Fz-mediated membrane recruitment of the cytoplasmic effector Dishevelled (Dvl) is a critical step in Wnt/β-catenin signaling initiation, but how Fz and Dvl act together to drive downstream signaling events remains largely undefined. Here, we use an Fz peptide-based microarray to uncover a mechanistically important role of the bipartite Dvl DEP domain and C terminal region (DEP-C) in binding a three-segmented discontinuous motif in Fz. We show that cooperative use of two conserved motifs in the third intracellular loop and the classic C-terminal motif of Fz is required for DEP-C binding and Wnt-induced β-catenin activation in cultured cells and Xenopus embryos. Within the complex, the Dvl DEP domain mainly binds the Fz C-terminal tail, whereas a short region at the Dvl C-terminal end is required to bind the Fz third loop and stabilize the Fz-Dvl interaction. We conclude that Dvl DEP-C binding to Fz is a key event in Wnt-mediated signaling relay to β-catenin. The discontinuous nature of the Fz-Dvl interface may allow for precise regulation of the interaction in the control of Wnt-dependent cellular responses.
Homogenization Processes and Retrieval of Equivalent Constitutive Parameters for Multisurface-Metamaterials

Different procedures are presented for the retrieval of effective constitutive parameters of metamaterial structures realized by multilayer lossless periodic structures. These structures are modeled as Floquet-wave based multiport networks connected by pieces of transmission lines. A generalized Bloch method is then adopted to find the dominant modes of the volumetric homogenized metamaterial. Starting from the results of this analysis, the constitutive tensors of an equivalent homogeneous material are defined. Different levels of equivalence are defined, denoted as “external equivalence,” “dispersion equivalence,” “single-mode equivalence,” and “double-mode equivalence. ” The corresponding homogenization processes are characterized by an increasing level of completeness (in the description of the metamaterial behavior) and of sophistication (concerning the processing of the full-wave analysis outcomes). The defined homogenization procedure accounts for dispersion in time (frequency) and space (wavenumber), as well as for anisotropy.
Human resources – strength and weakness in protection of intellectual capital

Purpose – Human resources in knowledge intensive industries create the basis for continuing innovation and subsequent firm performance. At the same time, they pose risks for the competitiveness of the firm: unwanted leaking of knowledge and intellectual capital to outsiders exposes firm-critical knowledge, and knowledge leaving with a departing key employee may jeopardise the firm’s projects. The purpose of this paper is to examine how human resource management can serve as a protection mechanism to diminish knowledge leaking and leaving via employees. Design/methodology/approach – The authors approach these issues through a case study utilising interview data from 22 interviews within two large research and development intensive firms. Findings – Human resources could be seen both as a strength and weakness of a firm with respect to knowledge protection. The findings indicate that there are numerous practices related to commitment, trust, motivation, and sense of responsibility available to deploy to str.
Prognostic impact of membranous ATP-binding cassette Sub-family G member 2 expression in patients with colorectal carcinoma after surgical resection

ATP-binding cassette sub-family G member 2 (ABCG2) is a transporter protein that has been associated with multidrug resistance and poor prognosis in several types of cancers. In colorectal cancers, however, the prognostic value of ABCG2 expression is not yet clear. ABCG2 expression was analyzed by immunohistochemistry using tissue microarrays in 234 consecutive patients who underwent surgical resection. The ABCG2 expression level was defined by the composite score, determined by multiplying intensity and percentage of tumor staining scores. This was dichotomized at the median, and the association of ABCG2 expression with disease severity and patient survival was determined. ABCG2 expression in the cytoplasm and membrane was observed in 77.8% and 61.5% of the samples, respectively. High expression of ABCG2 in both the cytoplasm and membrane was found more frequently in well-differentiated lesions (P < 0.05). High expression of membranous ABCG2 was significantly associated with better overall survival (hazard ratio [HR], 0.624; 95% confidence interval [CI], 0.411–0.948; P = 0.027) and disease-specific survival (HR, 0.499; 95% CI, 0.308 - 0.808; P = 0.005) compared to low expression. However, cytoplasmic expression of ABCG2 was not significantly associated with patient survival. The expression level of membranous ABCG2 in colorectal tumors can predict post-operative patient survival, suggesting the potential for ABCG2 as a prognostic biomarker.
Allocation of Authority in Franchise Chains

This paper investigates the determinants of the allocation of formal and real authority in franchise chains. Differences in business features, such as the required standardization and monitoring costs, explain the allocation of authority between the franchisor and franchisees. These variables affect the trade-off between the risk of brand name loss and the gains in knowledge sharing and learning within the network. The higher the need for standardization, the higher the risk of brand name loss, and, consequently, the more likely the franchisor is to adopt an organizational design that confers more control over the decisions of franchisees, such as business format franchising. This paper presents an empirical analysis of 223 franchise chains that provides support to the hypothesis of a negative effect of the required standardization on the level of delegation.
Spreading the Gains from Globalization : What Can Be Learned from Value-Chain Analysis?

In recent years, globalization has been associated with increasing inequality within and between countries, and with a stubbornly large share of the world's population living in poverty. If the "losers" had been confined to those who did not participate in the global economy, then the policy implications would be clear--join the rush. But, when (as is the case) the "losers" include those who have participated in global processes, then the policy challenge is much more daunting. It is not so much a matter of whether to participate in global processes, but how to do so in a way that provides sustainable income growth for poor people and for poor countries. In these circumstances, policy needs to address processes of production and product development, including both intrafirm organization and the relationship between firms. It also needs to address the ways in which poor producers and poor countries connect with producers and consumers in the global economy. Value-chain analysis--which includes the whole cycle of the organization, production, and delivery of products from inception to use and recycling-- provides a tool for mapping these crucial domains of private and public policy. But, more than that, by focusing on the dynamic shifting of producer rents through the chain, on the processes whereby key actors provide governance to production that occurs on a global basis, value-chain analysis provides important insights into the policy challenges confronting both private and public actors. This article reviews the unequal character of recent processes of globalization, summarizes the key theoretical concepts that characterize the concept of value chains, and illustrates the contribution of value-chain analysis through summaries of four chain case studies (fresh fruit and vegetables, canned deciduous fruit, footwear, and automobile components). It concludes with a discussion of practical ways of how value-chain analysis can inform policy.
How are the Children of Visible Minority Immigrants Doing in the Canadian Labour Market?

This paper examines the performance of the children of immigrants (2nd generation immigrants) to Canada using data from the 2006 Census. As the composition of immigration inflows has shifted after 1980 from the traditional European source countries to the Third World, the analysis focuses on the labour market performance of 2nd generation visible minority immigrants of whom there were 398 thousand aged15 and over who reported employment income in the Census. An encouraging fact revealed by the data is that 2nd generation visible minority immigrants are becoming more highly educated than 2nd generation non-visible minority immigrants and than non-immigrants – 46.2 per cent of 2nd generation visible minority between 25 and 44 earning employment had earned university certificates or degrees compared to 31 per cent of non-visible minority 2nd generation immigrants and 24 per cent of non-immigrants in the same age groups. But, while 2nd generation visible minority immigrants obtained more education than 2nd generation non-visible minority immigrants and non-immigrants, their performance as a group did not measure up in the labour market. In the 25 to 44 age group, accounting for the largest number of 2nd generation visible minority immigrants, they only earned on average $39,814, whereas 2nd generation non-visible minority immigrants earned $45,352 and non-immigrants 40,358. The labour market performance varies significantly among different visible minority groups. 2nd generation Chinese immigrants in the 25 to 44 age group actually earned $48,098, which was actually more than 2nd generation non-visible minority immigrants and non-immigrants. Because of the large number of Chinese included as 2nd generation immigrants, this buoyed up the overall average and masked the unfortunate fact that many other visible minority groups are doing much worse than average overall and falling short of non-immigrants. A troubling aspect of the performance of 2nd generation immigrants, except for Chinese and Japanese, is the extent to which they earn substantially less than non-immigrants and especially non-visible minority immigrants for any given level of education. The paper thus provides no grounds for complacency that the children of the recent, particularly non-Asian visible minority, immigrants who are performing so poorly in Canada’s labour market will catch up with non-immigrant groups, particularly given that their parents are currently performing much worse than earlier visible minority immigrants in the labour market. And it is unlikely that 2nd generation visible minority immigrants as a group will earn enough to make up for the current earnings shortfall experienced by their parents in recent cohorts of underperforming immigrants. Furthermore, the lower earnings of many visible minority groups for any given level of education are likely to continue be used as justification for more affirmative action programs. This will adversely affect the non-visible minority and non-immigrant population, and could become a source of increasing social tension.
Comparisons of trends in antiretroviral use and HIV notification rates between three Australian States

Objective: Notification rates for HIV among men who have sex with men (MSM) have been increasing, but this increase has not been uniform across States and Territories. This paper aims to determine whether differences in the levels of antiretroviral therapy (ART) were associated with differences in HIV notification rates between Australian States.
Local entrepreneurship clusters in cities

We show that entrepreneurs are co-located within cities. One plausible source of such spatial clustering is local social interactions, where individuals’ decisions to become entrepreneurs are influenced by entrepreneurial neighbors. Using geo-coded matched employer–employee data for Sweden, we find that sharing residential neighborhood with established entrepreneurs has a statistically significant and robust influence on the probability that an individual leaves employment for entrepreneurship. An otherwise average neighborhood with a 5% point higher entrepreneurial intensity, all else equal, produces between six and seven additional entrepreneurs per square kilometer, each year. Our estimates suggest a local feedback-effect in which the presence of established entrepreneurs in a neighborhood influences the emergence of new local entrepreneurs. Our analysis supports the conjecture that social interaction effects constitute a mechanism by which local entrepreneurship clusters in cities develop and persist over time.
A Study of the Regulatory Effect of the Employee Retirement Income Security Act

ON its face, the pension contract is tenuous. In exchange for lower cash wages, the firm promises workers pension payments many years in the future. Yet it can either terminate the plan at any time or fire workers prior to vesting; in either case, the firm can impose large capital losses on workers. Because of the complexity of the contract and its long-term nature, informational problems abound. In addition, the contract is largely implicit, making it essentially unenforceable in the courts. There is also a potential for a lemons market: if some firms perpetrate fraud, the expected "quality" of all pensions is reduced. Pensions appear to offer a classic example of a product that cannot survive in an unfettered competitive market, requiring at least some government regulation to ensure their survival. Congress apparently agreed. On Labor Day, 1974-following the assembly of a record showing patterns of layoffs and firings of long-term unvested workers and the termination of pension plans with insufficient assets to pay promised benefits-the Employee Retirement Income Security Act (ERISA) became law.2 While ERISA instituted various rules to