Miracle-dz/UniFAR-FTUs huggingface dataset:
Analysis of Ore-Controlling Factors and Prospecting Potential of the Luziyuan Lead-Zinc Deposit in West of Yunnan

Luziyuan lead-zinc deposit located in Fengwei, Zhenkang,Yunnan Province, at the direction of 140°, horizontal distance is about 10km. The deposit closely related to acidic magmatism and geological structure. According to the latest exploration results of Yunnan Geological Survey, the amount of lead-zinc resources is 280 million tons, it is super-mega deposit. Mineralization factors as tectonics, deep fault, concealed rock, ore formation and surface north-east trending fault zone control the formation of the deposit. Gravity abnormal, magnetic abnormal, geochemical abnormal and associated mineralization of the mine relate to prospecting potential.
Alexithymia and automatic processing of emotional stimuli: a systematic review

Abstract Alexithymia is a personality trait characterized by difficulties in recognizing and verbalizing emotions and the utilization of a cognitive style that is oriented toward external events, rather than intrapsychic experiences. Alexithymia is considered a vulnerability factor influencing onset and course of many psychiatric disorders. Even though emotions are, in general, elicited involuntarily and emerge without conscious effort, it is surprising that little attention in etiological considerations concerning alexithymia has been given to deficits in automatic emotion processing and their neurobiological bases. In this article, results from studies using behavioral or neurobiological research methods were systematically reviewed in which automatic processing of external emotional information was investigated as a function of alexithymia in healthy individuals. Twenty-two studies were identified through a literature search of Psycinfo, PubMed, and Web of Science databases from 1990 to 2016. The review reveals deficits in the automatic processing of emotional stimuli in alexithymia at a behavioral and neurobiological level. The vast majority of the reviewed studies examined visual processing. The alexithymia facets externally oriented thinking and difficulties identifying feelings were found to be related to impairments in the automatic processing of threat-related facial expressions. Alexithymic individuals manifest low reactivity to barely visible negative emotional stimuli in brain regions responsible for appraisal, encoding, and affective response, e.g. amygdala, occipitotemporal areas, and insula. Against this background, it appears plausible to assume that deficits in automatic emotion processing could be factors contributing to alexithymic personality characteristics. Directions for future research on alexithymia and automatic emotion perception are suggested.
Autonomic conditioning to monetary and social stimuli and aggression in children

Poor conditioning to punishment, such as loud tones or electric shock, has been proposed as an important factor involved in the etiology of aggressive and psychopathic behavior. However, it is not known whether the association holds when monetary or social stimulus is used as the unconditioned stimulus, and if aggressive individuals also have impaired conditioning to rewards. In this study, skin conductance responses in a conditioning task involving both monetary/social reward and punishment as unconditioned stimuli were assessed in 340 male and female 8- to 9-year-old children from the community. Children reported their reactive and proactive aggression using the Reactive and Proactive Aggression Questionnaire (RPQ; Raine et al., 2006). Results showed that monetary/social reward and punishment were effective in eliciting physiological classical conditioning in children, and that reduced reward conditioning was associated with high levels of proactive aggression in particular. Findings highlight the importance of distinguishing between reactive and proactive aggression when examining antisocial behavior in children, and suggest that reward-oriented treatment programs may not be effective for children with more proactive, instrumental aggressive behavior.
The Importance of Conveying Inter-Facet Relationships for Making Sense of Unfamiliar Domains

The design of online retail environments has improved significantly by including features such as faceted navigation, which provide meta-data to users as a means to apply constraints over the available products. The position held in this paper, and supported by a growing body of evidence, is that the specific implementation of such faceted experiences can increase the support for more exploratory searches and sensemaking in unfamiliar domains of information. The challenge remains, however, to understand exactly what aspects of the browsers support sensemaking and how. We conclude that the powerful models of information seeking used in recent research can be combined with sensemaking models to understand more about what interface elements support users as they progress in their knowledge acquisition during sensemaking and more exploratory tasks.
Combination of chemotherapy and gefitinib as first‐line treatment for patients with advanced lung adenocarcinoma and sensitive EGFR mutations: A randomized controlled trial

To explore the optimal treatment strategy for patients who harbor sensitive EGFR mutations, a head‐to‐head study was performed to compare chemotherapy and gefitinib in combination or with either agent alone as first‐line therapy, in terms of efficacy and safety. A total of 121 untreated patients with advanced lung adenocarcinoma who harbored sensitive EGFR mutations were randomly assigned to receive gefitinib combined with pemetrexed and carboplatin, pemetrexed plus carboplatin or gefitinib alone. The progression‐free survival (PFS) of patients in the combination group (17.5 months, 95% CI, 15.3–19.7) was longer than that of patients in the chemotherapy group (5.7 months, 95% CI, 5.2–6.3) or gefitinib (11.9 months, 95% CI, 9.1–14.6) group. The (hazard ratios) HRs of PFS for the combination group vs. chemotherapy and gefitinib groups were 0.16 (95% CI, 0.09–0.29, p < 0.001) and 0.48 (95% CI, 0.29–0.78, p = 0.003), respectively. The overall response rate (ORR) in the combination therapy group, chemotherapy group and the gefitinib group was 82.5%, 32.5% and 65.9%, respectively. The combinational strategy resulted in longer overall survival (OS) than chemotherapy (HR = 0.46, p = 0.016) or gefitinib (HR = 0.36, p = 0.001) alone. Our finding suggested that treatment with pemetrexed plus carboplatin combined with gefitinib could provide better survival benefits for patients with lung adenocarcinoma harboring sensitive EGFR mutations.
Irritable bowel syndrome and inflammatory bowel disease overlap syndrome: pieces of the puzzle are falling into place

Irritable bowel syndrome (IBS), a common gastrointestinal disorder involving the gut-brain axis, and inflammatory bowel disease (IBD), a chronic relapsing inflammatory disorder, are both increasing in incidence and prevalence in Asia. Both have significant overlap in terms of symptoms, pathophysiology, and treatment, suggesting the possibility of IBS and IBD being a single disease entity albeit at opposite ends of the spectrum. We examined the similarities and differences in IBS and IBD, and offer new thoughts and approaches to the disease paradigm.
A double-blind, placebo-controlled study of inositol in trichotillomania

Trichotillomania is characterized by repetitive pulling that causes noticeable hair loss. Data on the pharmacological treatment of trichotillomania are limited, with no clear first-line agent. The aim of the current study was to determine the efficacy and tolerability of inositol in adults with trichotillomania. A total of 38 individuals (35 women; mean age: 28.9±11.4) with trichotillomania entered a 10-week, double-blind, placebo-controlled trial to evaluate the safety and efficacy of inositol (dosing ranging from 6 to 18 g/day). Patients were assessed using the Massachusetts General Hospital Hair Pulling Scale, the NIMH Trichotillomania Severity Scale, Clinical Global Impression Scale, and measures of depression, anxiety, and psychosocial functioning. Outcomes were examined using a linear mixed-effects model. Patients assigned to inositol failed to show significantly greater reductions on primary or secondary outcomes measures compared with placebo (all P>0.05). At study endpoint, 42.1% of patients were ‘much or very much improved’ on inositol compared with 35.3% on placebo. This is the first study assessing the efficacy of inositol in the treatment of trichotillomania, but found no differences in symptom reductions between inositol and placebo. Future studies should examine whether inositol may be beneficial in controlling pulling behavior in a subgroup of individuals with trichotillomania.
Mite allergens

Sensitization to house dust mite allergens (HDM) is a major risk factor for asthma worldwide, particularly in the Tropics where they grow abundantly all year [1]. They are also risk factors for rhinitis [2] and food-induced anaphylaxis [3]. Some other potential activities have been suggested for HDM or their components, for example, oxidative damage to proteins, lipids, and DNA in lung cells [4] or induction of gastrointestinal inflammation by the enzymatic properties of Der p 1 [5]. Molecular studies have been improved by the production of HDM allergens as recombinant molecules, now available for component resolved diagnosis (CDR) and the designing of potential allergy vaccines. Here I analyze how these developments have been useful and what remains to be done to get closer to personalized medicine.
Enhancement of mixing performance of single‐screw extrusion processes via chaotic flows: Part II. Numerical study

In the accompanying article, Part I, we have described the basic mechanism of chaotic mixings due to a new “Chaos Screw” in single-screw extrusion processes, and presented experimental evidence of the chaotic mixing in a single-screw extruder with a typical Chaos Screw installed. The present article, Part II, will be focused on the numerical investigations of the chaotic flows via the Chaos Screw in a single-screw extruder. The three-dimensional velocity fields in both the no-barrier and barrier regions were separately calculated via a finite element analysis of the quasi–three-dimensional flow in each region, and were subsequently used in the numerical simulations of chaotic flow behaviors. Extensive numerical simulation results will be presented in terms of particle trajectories, Poincare sections, and mixing patterns for several dimensionless parameters. It was found that invariant manifolds obtained by numerical simulations were in good agreement with those from experiments. © 1996 John Wiley & Sons, Inc.
PSEUDO-RESPONSE REGULATORS 9, 7, and 5 Are Transcriptional Repressors in the Arabidopsis Circadian Clock[W][OA]

PSEUDORESPONSE REGULATOR9 (PRR9), PRR7, and PRR5 regulate the Arabidopsis circadian clock. PRR9, PRR7, and PRR5 proteins associate with CIRCADIAN CLOCK ASSOCIATED1 and LATE ELONGATED HYPOCOTYL promoters in a sequential manner to repress their expression. A conserved region common to the three PRR proteins is sufficient for repressor activity. An interlocking transcriptional-translational feedback loop of clock-associated genes is thought to be the central oscillator of the circadian clock in plants. TIMING OF CAB EXPRESSION1 (also called PSEUDO-RESPONSE REGULATOR1 [PRR1]) and two MYB transcription factors, CIRCADIAN CLOCK ASSOCIATED1 (CCA1) and LATE ELONGATED HYPOCOTYL (LHY), play pivotal roles in the loop. Genetic studies have suggested that PRR9, PRR7, and PRR5 also act within or close to the loop; however, their molecular functions remain unknown. Here, we demonstrate that PRR9, PRR7, and PRR5 act as transcriptional repressors of CCA1 and LHY. PRR9, PRR7, and PRR5 each suppress CCA1 and LHY promoter activities and confer transcriptional repressor activity to a heterologous DNA binding protein in a transient reporter assay. Using a glucocorticoid-induced PRR5-GR (glucorticoid receptor) construct, we found that PRR5 directly downregulates CCA1 and LHY expression. Furthermore, PRR9, PRR7, and PRR5 associate with the CCA1 and LHY promoters in vivo, coincident with the timing of decreased CCA1 and LHY expression. These results suggest that the repressor activities of PRR9, PRR7, and PRR5 on the CCA1 and LHY promoter regions constitute the molecular mechanism that accounts for the role of these proteins in the feedback loop of the circadian clock.
Numerical Study of Impact Penetration Shearing Employing Finite Strain Viscoplasticity Model Incorporating Adiabatic Shear Banding

This work brings forward a twofold contribution relevant to the adiabatic shear banding (ASB) process as a part of dynamic plasticity of high-strength metallic materials. The first contribution is a reassessment of a three-dimensional finite deformation model starting from a specific scale postulate and devoted to cover a wide range of dissipative phenomena, including ASB-related material instabilities (strong softening prefailure stage). The model, particularly destined to deal with impacted structures was first detailed by (Longere et al. 2003, "Modelling Adiabatic Shear Banding Via Damage Mechanics Approach, " Arch. Mech., 55, pp. 3-38; 2005, "Adiabatic Shear Banding Induced Degradation in a Thermo-Elastic/Viscoplastic Material Under Dynamic Loading," Int. J. Impact Eng., 32, pp. 285-320). The second novel contribution concerns numerical solution of a genuine ballistic penetration problem employing the above model for a target plate material. The ASB trajectories are shown to follow a multistage history and complex distribution pattern leading finally to plugging failure mechanism. The corresponding analysis and related parametric study are intended to put to the test the pertinency of the model as an advanced predictive tool for complex shock related problems.
Success of ophthalmic pharmaceutical start‐up companies

within the Heidelberg software. We are concerned that the automated segmentation and/or its interpretation did not provide valid data on the exact layer thickness in micrometre and are reluctant to accept conclusions drawn from these numbers. The main finding of correlation between GCL thickness and disease severity remains, in our opinion, therefore doubtful. Reanalysis and interpretation of the data are highly recommended.
Multihop Alternate Cluster Head Fault Tolerant Dynamic Clustering Protocol for Wireless Sensor Network

This paper introduces MACH-FTDC (Multihop Alternate Cluster Head Fault Tolerant – Dynamic Clustering) protocol for wireless sensor network that provides fault tolerance as well as reduced data loss with mobility as compared to the existing FT-DSC protocol. It introduces mobility which is important to some of the real world applications. This protocol does tradeoff between sensor node energy and data availability. For most of the applications, data is of utmost importance and hence this protocol focuses more on data availability and reduces loss of data at the cost of energy. Wireless sensor network is prone to failure due many reasons such as hardware faults, damage to sensor nodes while its deployment, software faults, energy depletion etc. Due to this, wireless sensor network is required to be fault tolerant. MACH-FTDC has reduced data loss achieving more data availability and provides mobility to WSN which is necessary for some applications.
Effect of preoperative skull block on pediatric moyamoya disease.

OBJECT Stable hemodynamics, normocapnia, and adequate pain relief are considered important factors in the reduction of neurological complications in pediatric patients undergoing encephaloduroarteriomyosynangiosis (EDAMS) operations for the treatment of moyamoya disease. A preoperative skull block may reduce hemodynamic fluctuations and hypo- or hyperventilation due to emergence delirium or oversedation and provide adequate pain relief, thereby reducing postoperative morbidity. METHODS Pediatric patients (age 3-13 years) undergoing EDAMS surgery for moyamoya disease were randomly divided into a nerve block (NB) group (18 cases) or control group (21 cases). The treatment group patients received a preoperative NB (0.25% 5-8 ml bupivacaine mixed with 20-40 mg methylprednisolone) targeting the supraorbital, supratrochlear, auriculotemporal, and posterior auricular nerves. Patients in the control group did not receive NB. General anesthesia with sevoflurane was induced in both groups. RESULTS In the NB group, stable hemodynamic parameters were obtained with a lower sevoflurane concentration than in the control group. For delirious awakening, the odds ratio in the control group was 4.9 compared with the NB group. Pain and analgesic requirement were higher in the control patients than in the NB-treated patients during the postanesthesia care unit stay. However, the arterial CO(2) tension in the postanesthesia care unit did not differ between the 2 groups. The odds ratio in the control group for the rate of morbidity (cerebral infarction and reversible ischemic neurological deficits) during the first 24 hours following the operation was 3.2 compared with the NB group. CONCLUSIONS The use of skull block during EDAMS surgery provided easy hemodynamic control, calm awakening, and better pain relief and may be related to the reduced postoperative morbidity.
Interactive comment on “ Contribution of Marine Group II Euryarchaeota to cyclopentyl tetraethers in the Pearl River estuary and coastal South China Sea : impact on the TEX 86 paleothermometer ” by J

Reply to general comments: We acknowledge that this reviewer’s comments are important and thoughtful. We have done makeup experiments to quantify the abundances of MG I (AOA) and total DNA from the same filter samples (Table 1 and Fig. 5). The qPCR date exhibited that MG II was statistically higher (duplicate experiments) than MG I in the mixing water and seawater, which suggests that MG II predominantly occurred in the water column of sampling stations at the Pearl River Estuary and coastal South China Sea. These results yet seem to be different from the 454 sequencing data (Fig. C7687
Approximate max-flow min-(multi)cut theorems and their applications

Consider the multicommodity flow problem in which the object is to maximize the sum of commodities routed. We prove the following approximate max-flow min-multicut theorem: $$ \dst \frac{\mbox{\rm min multicut}}{O(\log k)} \leq \mbox{ \rm max flow } \leq \mbox{ \rm min multicut}, $$ \noindent where $k$ is the number of commodities. Our proof is constructive; it enables us to find a multicut within $O(\log k)$ of the max flow (and hence also the optimal multicut). In addition, the proof technique provides a unified framework in which one can also analyse the case of flows with specified demands of Leighton and Rao and Klein et al. and thereby obtain an improved bound for the latter problem.
Population dynamics and genetics in inhomogeneous media

Aquatic environments are a natural ecosystem for a large variety of living organisms. In such ecosystems the level of inhomogeneities is high and inhomogeneities can influence the dynamics and the genetics of a population that is growing and expanding in such an environment. Moreover displacement due to self-propulsion can sum up with turbulent dispersion at larger scales to influence the local densities and thus population and genetic dynamics. In this work the expansion of a population, consisting of two subpopulations differing for neutral alleles, in inhomogeneous environments is investigated numerically using a discrete particle model with certain rules for birth, death by competition and displacement by diffusion. First the focus is on ‘internal’ inhomogeneities, induced by self-propulsion of interacting and reactive particles and modeled as a density-dependent motility of individuals. In this case spatial structures develop in the population in the form of high and low density regions. The clustering dynamics and the influence of the spatial structures on the genetics is explored numerically. The genetics is measured by means of standard statistical observables such as fixation time, that is found to be strongly influenced by the level of communication between high density peaks. Secondly the situation of front propagation in a medium with ‘external’ inhomogeneities is investigated. When the population duplication time is much larger than the turnover time of eddies, a turbulent area can be modeled by replacing the microscopic diffusion coefficient by an enhanced effective total diffusivity. Numerical simulations with a non-homogeneous diffusion coefficient are employed to explore the effect of inhomogeneities on the population dynamics and genetics. Initially the effect of single modified areas is analyzed, then a quenched random medium is also considered. The front dynamics is characterized in terms of front shape and front speed and the genetic dynamics is characterized in terms of heterozygosity and fixation time. It was found that inhomogeneities accelerate the decay of the heterozygosity and reduce the global fixation time. Finally the connection between roughness of the front and the genetic boundaries motion is clarified in expanding populations. Special attention is given to the role of enhanced roughness in defining the fate of species correlation in random media.
A geometrical shift results in erroneous appearance of low frequency tissue eddy current induced phase maps

Knowledge on low frequency (LF) tissue conductivity is relevant for various biomedical purposes. To obtain this information, LF phase maps arising from time‐varying imaging gradients have been demonstrated to create a LF conductivity contrast. Essential in this methodology is the subtraction of phase images acquired with opposite gradient polarities to separate LF and RF phase effects. Here we demonstrate how sensitive these subtractions are with respect to geometrical distortions.
Effect of Equal Channel Angular Pressing (ECAP) on Erosion-Corrosion of Pure Copper

During the past few decades, ultrafine-grained materials (UFG) have experienced rapid development. Enhanced mechanical and surface properties, such as strength, ductility and erosion-corrosion (E-C) resistance by refining the grain to ultra-fine/nanometer size has been achieved. The equal channel angular pressing (ECAP) is a popular severe plastic deformation (SPD) method to fabricate UFG bulk materials. In this research, the E-C behavior of commercial annealed pure copper subject to four passes of ECAP have been investigated. Hardness measurement of the copper specimen after four passes of ECAP showed an increase of 200% on the hardness value as compared with annealed condition. Simulated seawater was used as an E-C medium. The effect of different E-C parameters such as time, slurry flow velocity, impact angle, and solid particle concentration on ECAP process is studied. The results showed that ECAP enhances the E-C resistance of copper, and this behavior improves with increasing the pass number. Generally, a 30% rise in resistance to E-C was achieved after four ECAP passes as compared to coarse grain copper for the parameters studied in this work. Optical microscopy was used to examine the microstructure and material removal mechanism of the annealed copper. Scanning electron microscopy (SEM) was used to validate the reduction of grain size due to ECAP process. Furthermore, examination of the surface roughness of the copper at different ECAP passes showed that for the same E-C condition the increment of ECAP passes leads to a smoother surface.