Miracle-dz/UniFAR-FTUs huggingface dataset:
Adaptive dynamic power management for hard real-time pipelined Multiprocessor Systems

Energy efficiency is a critical design concern for embedded systems. Dynamic power management (DPM) schemes in Multiprocessor System on Chips (MPSoCs) has been wildly used to explore the idleness of processors and dynamically reduce the energy consumption by putting idle processors to low-power states. In this paper, we explore how to effectively apply dynamic power management in adaptive manner to reduce leakage power consumption for coarse-grained pipelined systems under hard real-time requirements. At each adaptive point, a system transformation is proposed to model the pipeline system with unfinished events as multi-stream system. By using extended pay-burst-only-once principle, the service curves for corresponding stream can be computed as a constraint for a minimal resource demand and energy minimization problem can be formulated with respect to the resource demands at each adaptive point. One light-weight heuristic, called balance workload scheme (BWS), is proposed in this paper to solve the minimization problem. Simulation results using real-life applications are presented to demonstrate the effectiveness of our approach.
Species Independence in Brain Tissue Binding Using Brain Homogenates

Species independence of brain tissue binding was assessed with a large number of structurally diverse compounds using equilibrium dialysis with brain homogenates of seven species and strains (Wistar Han rat, Sprague-Dawley rat, CD-1 mouse, Hartley guinea pig, beagle dog, cynomolgus monkey, and human). The results showed that the fractions unbound of the seven species and strains were strongly correlated with correlation coefficients ranging from 0.93 to 0.99. The cross-species/strain correlations were not significantly different from the interassay correlation with the same species. The linear correlation between Wistar Han and other species had a slope close to 1 and an intercept near 0. Based on orthogonal statistical analysis, no correction is needed for extrapolation of fraction unbound from Wistar Han rat to the other species or strains. Hence, brain tissue binding of Wistar Han rat can be used to obtain binding of other species and strains in drug discovery.
Automatic recognition and tagging of topologically different regimes in dynamical systems

Complex systems are commonly modeled using nonlinear dynamical systems. These models are often high-dimensional and chaotic. An important goal in studying physical systems through the lens of mathematical models is to determine when the system undergoes changes in qualitative behavior. A detailed description of the dynamics can be difficult or impossible to obtain for high-dimensional and chaotic systems. Therefore, a more sensible goal is to recognize and mark transitions of a system between qualitatively different regimes of behavior. In practice, one is interested in developing techniques for detection of such transitions from sparse observations, possibly contaminated by noise. In this paper we develop a framework to accurately tag different regimes of complex systems based on topological features. In particular, our framework works with a high degree of success in picking out a cyclically orbiting regime from a stationary equilibrium regime in high-dimensional stochastic dynamical systems.
Osmoregulation in Escherichia coli: complementation analysis and gene-protein relationships in the proU locus

The proU locus in Escherichia coli encodes an osmotically inducible transport system for two substrates, glycine betaine and L-proline, whose intracellular accumulation represents an important component in the physiology of osmoregulation. Several osmoresponsive proU::lac mutants were isolated and tested for complementation with plasmids carrying different functional regions of proU. Three classes of mutations were identified which were physically mapped to distinct regions of DNA from this locus. Tn1000-insertion mutagenesis of cloned proU DNA also yielded three phenotypic classes of mutations whose physical distribution approximately corresponded with those of the chromosomal mutants above. Three proteins, of Mr 44,000, 35,000, and 33,000, were shown to be products of proU, and the last of these was localized to the periplasmic space. The data indicate that proU is an operon with three genes, designated in order proV, proW, and proX, encoding respectively the gene products above. All three genes were shown to be necessary for exhibition of the proU-mediated osmoprotective effects of both glycine betaine and L-proline in E. coli.
Pre-Announcement of Insiders' Trades

Among the reactions to recent corporate scandals are calls for greater transparency of insiders' trades. The Securities and Exchange Commission's recent rule on fair disclosure is accompanied by a safe harbor from prosecution under insider trading laws for insiders who pre-commit to trades. A blue-ribbon commission convened to address recent financial scandals and subsequent decline in investor confidence recommended that insiders be required to preannounce sales of stock in their companies. The commission's call for insiders to preannounce their sales echoes proposals made over a decade ago in the legal press, law reviews, and the U.S. Congress that would require pre-announcement of all trades. We consider the effects of insiders pre-announcing their trades on their preferences for public disclosure that would pre-empt their private information when other motives for insiders to trade are present. Two principal forces emerge. With pre-announcement, insiders cannot expect to profit on their private information, but cannot ignore the incentive to do so when market makers are unable to disentangle insiders' motives. Pre-emptive public disclosure allows insiders to avoid the dysfunctional consequences of this incentive. However, such disclosure before insiders have an opportunity to trade exposes them to greater price risk than would otherwise be the case. Our analysis demonstrates these effects.
International Evidence on Ethical Mutual Fund Performance and Investment Style

Using an international database containing 103 German, UK and US ethical mutual funds, we review and extend previous research on ethical mutual fund performance. By applying a multi-factor Carhart (1997) model we solve the benchmark problem most prior ethical studies suffered from. After controlling for investment style, we find little evidence of significant differences in risk-adjusted returns between ethical and conventional funds for the 1990-2001 period. Introducing time variation in betas however leads to a significant under-performance of domestic US funds and a significant out-performance of UK ethical funds, relative to their conventional peers. Finally, we differentiate previous results by documenting a learning effect. After a period of strong under-performance, older ethical funds finally are catching up, while younger funds continue to under-perform both the index and conventional peers.
CALOGERO-MOSER SPACE, RESTRICTED RATIONAL CHEREDNIK ALGEBRAS AND TWO-SIDED CELLS.

We conjecture that the ``nilpotent points" of Calogero-Moser space for reflection groups are parametrised naturally by the two-sided cells of the group with unequal parameters. The nilpotent points correspond to blocks of restricted Cherednik algebras and we describe these blocks in the case $G = \mu_{\ell}\wr \mathfrak{S}_n$ and show that in type $B$ our description produces an existing conjectural description of two-sided cells.
Effects of cigarette smoking, metabolic syndrome and dehydroepiandrosterone deficiency on intima-media thickness and endothelial function in hypertensive postmenopausal women

Summary Background Cigarette smoking is a major risk factor of atherosclerosis. The aim of this study was to assess the relationship between smoking and arterial hypertension as well as endothelial dysfunction in postmenopausal women without clinically manifested symptoms of atherosclerosis. Material/Methods The study groups consisted of 35 current smokers and 45 nonsmokers. The thickness of intima-media complex (IMT), a marker of atherosclerosis, was measured in carotid arteries. Plasma concentrations of fasting glucose, insulin, lipoproteins, inflammatory markers (tumor necrosis factor-alpha, intercellular adhesion molecule-1), matrix metalloproteinases (metalloproteinase-9, tissue inhibitor of metalloproteinase-1), insulin, and dehydroepiandrosterone sulfate (DHEA-S) were measured. Results Smokers compared with nonsmokers showed lower fasting glucose levels in blood (87.0±10.9 and 93.2±13.6 mg/dl, p<0.05), higher mean systolic (131.1±15.9 vs. 123.0±10.9 mm Hg, p<0.05) and diastolic (81.7±11.4 vs. 75.2±9.2 mm Hg, p<0.05) blood pressure during daytime, and higher average heart rate during the daytime (78.2±9.3/min vs. 71.5±9.5/min, p<0.01) and at night (67.2±10.6/min vs. 61.7±7.7/min, p<0.05), respectively. The IMT in the right carotid artery was significantly higher in smokers than in nonsmokers (0.96±0.16 mm vs. 0.82±0.21, p<0.05) and was positively correlated with smoking intensity (R=0.36) and habit duration (R=0.35). The comparison of inflammatory markers, metalloproteinases, and DHEA-S concentrations in plasma did not reveal significant differences between the 2 groups. A significant negative correlation between DHEA-S concentration in plasma and IMT in right carotid artery was found in smokers. Conclusions Smoking in hypertensive postmenopausal women is associated with lower fasting blood glucose and BMI values, but higher arterial pressure and heart rate, and increases in IMT in right carotid artery.
Combinations of Cocaine with Other Dopamine Uptake Inhibitors: Assessment of Additivity

Drugs that inhibit dopamine (DA) reuptake through actions at the dopamine transporter (DAT) have been proposed as candidates for development as pharmacotherapies for cocaine abuse. Accordingly, it is important to understand the potential pharmacological interactions of cocaine with other drugs acting at the DAT. Effects of combinations of cocaine with a cocaine analog, 2β-carbomethoxy-3β-(4-fluorophenyl)tropane (WIN 35,428), were compared quantitatively with the combinations of cocaine with the N-butyl,4′,4″-diF benztropine analog, 3-(bis(4-fluorophenyl)methoxy)-8-butyl-8-azabicyclo[3.2. 1]octane (JHW 007), to determine whether their effects on DA levels in the shell of the nucleus accumbens (NAC) in mice differed. Each of the drugs alone produced dose-related elevations in NAC DA levels. In contrast to the other drugs, JHW 007 was less effective, producing maximal effects that approached 400% of control versus ∼700% with the other drugs. In addition, the JHW 007 dose-effect curve was not as steep as those for cocaine and WIN 35,428. Combinations of cocaine with its analog, WIN 35,428, were most often greater than those predicted based on dose additivity. In contrast, combinations of cocaine with JHW 007 were most often subadditive. This outcome is consistent with recent studies suggesting that structurally divergent DA uptake inhibitors bind to different domains of the DAT, which can result in different DAT conformations. The conformational changes occurring with JHW 007 binding may result in functional outcomes that alter its abuse liability and its effects in combination with cocaine.
Screening for hypertension in a primary care dental clinic.

OBJECTIVE The aim of this study was to record blood pressure in patients during their visit to a dental clinic, with the aim of identifying those who have high blood pressure and are unaware of it, as well as those who are aware of their condition but do have their blood pressure under adequate control. STUDY DESIGN We designed a cross-sectional study which included 154 patients who were seen for a dental checkup at the Primary Dental Care of the Gallician Health Service (SERGAS). All participants completed a standardized medical questionnaire after measuring their systolic blood pressure (SBP) and diastolic blood pressure (DBP), which was conducted using the protocol established by the Spanish Society of Hypertension-Spanish League for the Fight Against Hypertension (HTA). RESULTS In 45 patients (29%), the figures for blood pressure were recorded as SBP>or=140 mmHg and/or DBP>or=90 mmHg, indicating that they may have hypertension. Only 12 of them had been previously diagnosed with hypertension, but did not have their blood pressure under adequate control. The remaining 33 had no history of hypertension and were referred to a family physician, but only 19 saw their doctor; 11 of these patients were given non-pharmacological treatment, 6 were prescribed drug treatment and no type of treatment was indicated for the other two patients. CONCLUSIONS By screening for hypertension, especially among patients who are more than 40 years old, the dentist can play an important role in the early diagnosis.
Finding Causes of Software Failure Using Ridge Regression and Association Rule Generation Methods

An important challenge in finding latent errors in software is to find predicates which have the most effect on program failure. Since predicates have mutual effects on each other, it is not a good solution to analyze them in isolation, without considering the simultaneous effects of other predicates on failure. The aim is to detect those predicates which are best bug predictors and meanwhile have the least effects among themselves. To achieve this, recursive ridge regression method has been applied. In order to determine the main causes of program failure, the association rule generation is used to detect those predicates which are most often observed with bug predictors in faulty executions. Based on the detected predicates, the faulty paths in control flow graph are introduced to the debugger. Our empirical results on two well-known test suites, EXIF and Siemens imply that the proposed approach could detect main causes of program failure with more accuracy.
Antistaphylococcal activities of CG400549, a new bacterial enoyl-acyl carrier protein reductase (FabI) inhibitor.

OBJECTIVES This study was performed to analyse in vitro and in vivo activities of CG400549, a new FabI inhibitor, against clinical isolates of staphylococci. The mode of action of CG400549 and resistance mechanism of Staphylococcus aureus against CG400549 were also investigated by genetic approaches. METHODS In vitro activity of CG400549 was evaluated by the 2-fold agar sdilution method as described by the CLSI, and compared with those of oxacillin, erythromycin, ciprofloxacin, sparfloxacin, moxifloxacin, gemifloxacin, vancomycin, linezolid and quinupristin-dalfopristin. In vivo activity of CG400549 was determined against systemic infections in mice. Time-kill curves of CG400549 were analysed at concentrations of 1 x , 2 x and 4 x MIC against S. aureus strains. RESULTS CG400549 had the lowest MICs among the test compounds against 238 clinical isolates of S. aureus (MIC90, 0.25 mg/L) and 51 clinical isolates of coagulase-negative staphylococci (MIC90, 1 mg/L). The activity of CG400549 was irrespective of whether the strains were methicillin-susceptible or -resistant. Furthermore, CG400549 was effective by oral or subcutaneous administration against systemic infections in mice. In a time-kill study, CG400549 at concentrations of 1 x MIC, 2 x MIC and 4 x MIC had a bacteriostatic activity during 24 h. A FabI-overexpressing S. aureus strain gave rise to an increase in the MIC of CG400549 compared with the parental strain, while the susceptibilities of the FabI-overexpressing S. aureus strain to the other antibacterial agents such as oxacillin, erythromycin and ciprofloxacin were not affected. This result showed that the mode of action of CG400549 was via inhibition of FabI, which is involved in biosynthesis of fatty acids in bacteria. Study of the resistance mechanism of S. aureus showed that CG400549-resistant mutants of S. aureus had an alteration in FabI at Phe-204 to Leu. CONCLUSIONS CG400549 had potent in vitro and in vivo activity against staphylococci, including methicillin-, ciprofloxacin- and multidrug-resistant staphylococci strains. This compound could be a good candidate for clinical development as a novel anti-MRSA drug.
Bimatoprost, prostamide activity, and conventional drainage.

PURPOSE Despite structural similarity with prostaglandin F(2 alpha), the ocular hypotensive agent bimatoprost (Lumigan; Allergan, Inc., Irvine, CA) shows unique pharmacology in vitro and functional activity in vivo. Unfortunately, the precise mechanisms that underlie bimatoprost's distinctive impact on aqueous humor dynamics are unclear. The purpose of the present study was to investigate the effects of bimatoprost and a novel prostamide-selective antagonist AGN 211334 on human conventional drainage. METHODS Two model systems were used to test the consequences of bimatoprost and/or AGN 211334 treatment on conventional drainage. Human anterior segments in organ culture were perfused at a constant flow rate of 2.5 microL/min while pressure was recorded continuously. After stable baseline facilities were established, segments were treated with drug(s), and pressure was monitored for an additional 3 days. In parallel, the drugs' effects on hydraulic conductivity of human trabecular meshwork (TM) cell monolayers were evaluated. Pharmacological properties of AGN 211334 were characterized in isolated feline iris preparations in organ culture and heterologously expressed G-protein-coupled receptors were examined in vitro. RESULTS Bimatoprost increased outflow facility by an average of 40% +/- 10% within 48 hours of treatment (n = 10, P < 0.001). Preincubation or coincubation with AGN 211334 significantly blunted bimatoprost's effects by 95% or 43%, respectively. Similar results were obtained in cell culture experiments in which bimatoprost increased hydraulic conductivity of TM cell monolayers by 78% +/- 25%. Pretreatment with AGN 211334 completely blocked bimatoprost's effects, while coincubation decreased its effects on average by 74%. In both models, AGN 211334 alone significantly decreased fluid flux across trabecular tissues and cells. CONCLUSIONS The findings indicate that bimatoprost interacts with a prostamide receptor in the trabecular meshwork to increase outflow facility.
Robots for rectopexy: probably hindrance... till now!

We thank Doctors Ian Lindsey and Aisling M. Hogan for their comments concerning our article recently published in Techniques in Coloproctology (1) they published in Annals of Laparoscopic and Endoscopic Surgery under the title “ robots for rectopexy: help or hindrance? ” (2).
The Role of Marital Adjustment in Suicidal Ideation Among Former Prisoners of War and Their Wives: A Longitudinal Dyadic Study

Objective: Posttraumatic stress symptoms (PTSS) are implicated in high suicidality and low levels of marital quality among traumatized veterans and their wives. However, the role of marital quality in suicidal ideation (SI) of war veterans and their spouses remains relatively unexplored. The current study examined the longitudinal associations between marital adjustment and SI among ex-prisoners of war (ex-POWs) and their wives. Method: Through opportunistic data collection, a sample of 233 Israeli couples (142 ex-POW couples and a comparison group of 91 veteran couples) were assessed at 2 time points: Time 1 (T1; 2003) and Time 2 (T2; 2008), 30 and 35 years after the 1973 Yom Kippur War. Participants completed self-report measures of PTSS, depression, dyadic adjustment, and SI. Results: Among both husbands and wives, higher levels of marital adjustment were related to lower levels of SI. Surprisingly, an actor-partner interdependence modeling analysis revealed that for both ex-POW and control groups, husband’s marital adjustment moderated the contribution of his PTSS to his SI, while controlling for prior SI in T1. Moreover, only for control couples did the husbands’ marital adjustment moderate the wives’ PTSS contribution to the husbands’ SI. Conclusions: Ex-POWs’ and their wives’ marital adjustment are longitudinally related to their SI. Improving couples’ marital adjustment may buffer the detrimental implications that both partners’ PTSS bears for veterans’ SI.
Joint transmit beamforming and antenna selection for energy efficiency maximization in MISO downlink

We study the joint beamforming and antenna selection problem for energy efficiency maximization in multi-user multiple-input single-output (MISO) downlink channel. By viewing antenna selection as finding a sparse solution, we first introduce a sparsity-inducing regularization term to the design problem. Since the resulting problem is nonconvex, it is difficult to find an optimal solution, and we apply a local optimization method based on the concept of sequential convex approximation (SCA) to solve this problem. By proper reformulations we arrive at a fast converging iterative algorithm, where a convex program is solved at each iteration. In the first design, we simply ignore antennas of which the associated beamformers are nearly zero and select the remaining ones. In the second design, we further perform the search over the selected antennas of the first design to improve the energy efficiency. Numerical results demonstrate remarkable performance gains of the proposed approaches in terms of energy efficiency over the solution without antenna selection.
Detecting similar applications with collaborative tagging

Detecting similar applications are useful for various purposes ranging from program comprehension, rapid prototyping, plagiarism detection, and many more. McMillan et al. have proposed a solution to detect similar applications based on common Java API usage patterns. Recently, collaborative tagging has impacted software development practices. Various sites allow users to give various tags to software systems. In this study, we would like to complement the study by McMillan et al. by leveraging another source of information aside from API usage patterns, namely software tags. We have performed a user study involving several participants and the results show that collaborative tagging is a promising source of information useful for detecting similar software applications.
Patients with depression display cytokine levels in serum and cerebrospinal fluid similar to patients with diffuse neurological symptoms without a defined diagnosis

Introduction Several reports indicate that inflammation may play a role in depression and demonstrate enhanced systemic levels of inflammatory mediators. We hypothesized that 44 patients with a diagnosis of depression would present with a specific and different serum and cerebrospinal fluid (CSF) cytokine profile compared to 21 patients with diffuse neurological symptoms, of whom 15 had fatigue as a major symptom, but no change in emotional state. Methods The diagnoses of the patients with depression were according to the International Classification of Diseases, tenth edition (F32–34 spectra). Cytokine profiles in serum and CSF were determined by multiplex analysis, including 27 cytokines, chemokines, and growth factors. Results No differences could be found between the two groups studied regarding cytokine levels in serum or CSF except for serum interleukin (IL)-1 receptor antagonist that was lower in the depression group. There were only four high correlations (>0.4) between serum and CSF levels of the cytokines, reflecting independent synthesis and turnover in these two compartments. In the control group, fatigue was associated with increased IL-1 receptor antagonist, IL-10, granulocyte-colony stimulating factor, and interferon-γ (all P<0.01). Conclusion Patients with depression had a similar cytokine profile as nondepressive patients, both systemically and in CSF. Fatigue was associated with higher levels of some inflammatory markers in the control group. It is possible that the presence of fatigue in a large proportion of patients and controls could contribute to the lack of difference in cytokine levels between these two groups.