Miracle-dz/UniFAR-FTUs huggingface dataset:
ABO blood groups, Rhesus factor, and Behçet's disease.

INTRODUCTION Recently, numerous studies have been carried out to explain the genetics and immunopathogenesis of Behçet's disease (BD). There is still insufficient understanding of its etiopathogenesis, but substantial genetic and immune system abnormalities have been suggested. Several studies have shown remarkable associations of ABO blood groups with various diseases. This study investigated the relationship between ABO and Rhesus (D) blood groups and Behçet's disease in Turkish patients. METHODS Clinical data on gender, ABO, and Rhesus blood type of patients with BD were collected at the Kayseri Education and Research Hospital from 2005 to 2012. A total of 115 patients with BD were assessed for their association with ABO or Rhesus (D) blood groups and compared with the distribution of the blood groups of 25,701 healthy donors admitted to the Kayseri Education and Research Hospital Blood Center in 2010 and 2011. RESULTS The distribution of ABO and Rhesus blood groups in patients with BD was similar to the healthy donors. No relationship was found between ABO or Rhesus blood groups and BD at our hospital. CONCLUSION Further studies with a larger series and in different centers may be valuable for identifying the association between ABO or Rhesus (D) blood groups and BD.
THE CHARACTERISTICS AND NEURAL SUBSTRATES OF FEEDBACK-BASED DECISION PROCESS IN RECOGNITION MEMORY

THE CHARACTERISTICS AND NEURAL SUBSTRATES OF FEEDBACK-BASED DECISION PROCESS IN RECOGNITION MEMORY by Sanghoon Han Department of Psychology and Neuroscience Duke University Date: ___________________________ Approved: _________________________________ Ian G. Dobbins, Co-Supervisor _________________________________ Elizabeth Marsh, Co-Supervisor _________________________________ Gavan Fitzsimons _________________________________ Scott A. Huettel _________________________________ David Madden An abstract of a dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Psychology and Neuroscience in the Graduate School of Duke University
How long can folinic acid rescue be delayed after high‐dose methotrexate without toxicity?

To determine the optimal time of folinic acid rescue after methotrexate (MTX) treatment in patients with ALL, we selected and evaluated relevant studies that included doses, rescue delay, and side effects. Rescue at 42–48 hours resulted in considerable toxicity, except when low doses of MTX were used (1 g/m2) or serum MTX levels remained consistently low at 24, 30, and 36 hours. Rescue started at 30–36 hours was safe. In the absence of evidence that later rescue improves prognosis, we suggest that folinic acid rescue (105 mg/m2) be started no later than 36 hours from the start of MTX (5–6 g/m2). Pediatr Blood Cancer 2014;61:7–10. © 2013 Wiley Periodicals, Inc.
An overview of PCI in the very elderly

Cardiovascular disease, and in particular ischemic heart disease (IHD), is a major cause of morbidity and mortality in the very elderly (> 80 years) worldwide. These patients represent a rapidly growing cohort presenting for percutaneous coronary intervention (PCI), now constituting more than one in five patients treated with PCI in real-world practice. Furthermore, they often have greater ischemic burden than their younger counterparts, suggesting that they have greater scope of benefit from coronary revascularization therapy. Despite this, the very elderly are frequently under-represented in clinical revascularization trials and historically there has been a degree of physician reluctance in referring them for PCI procedures, with perceptions of disappointing outcomes, low success and high complication rates. Several issues have contributed to this, including the tendency for older patients with IHD to present late, with atypical symptoms or non-diagnostic ECGs, and reservations regarding their procedural risk-to-benefit ratio, due to shorter life expectancy, presence of comorbidities and increased bleeding risk from antiplatelet and anticoagulation medications. However, advances in PCI technology and techniques over the past decade have led to better outcomes and lower risk of complications and the existing body of evidence now indicates that the very elderly actually derive more relative benefit from PCI than younger populations. Importantly, this applies to all PCI settings: elective, urgent and emergency. This review discusses the role of PCI in the very elderly presenting with chronic stable IHD, non ST-elevation acute coronary syndrome, and ST-elevation myocardial infarction. It also addresses the clinical challenges met when considering PCI in this cohort and the ongoing need for research and development to further improve outcomes in these challenging patients.
Regulation of differentiated properties and proliferation of arterial smooth muscle cells.

D uring recent years, it has become increasingly evident that arterial smooth muscle cells occur in at least two distinct states, usually referred to as a synthetic and a contractile phenotype. Synthetic-state cells have a fibroblast-like appearance, and their main functions are to proliferate and to produce extracellular matrix components. They are found in the embryo and the young growing organism, where they take part in the formation of the vessel wall. Contractile-state cells have a musclelike appearance and contract in response to chemical and mechanical stimuli. They predominate in the vessels of adults and are primarily involved in the control of blood pressure and flow. However, these cells are able to return to a synthetic phenotype, and this appears to be an important early event in atherogenesis. This review briefly summarizes the present knowledge concerning the regulation of differentiated properties and proliferation of arterial smooth muscle cells. Most of the discussion will deal with studies on cultured cells, which so far are the most abundant. Particular attention will be paid to the role of extracellular matrix components like fibronectin and laminin and of polypeptide mitogens like platelet-derived growth factor (PDGF). It is believed that future studies in this area will help to widen our understanding of vasculogenesis and the initial stages in the pathogenesis of atherosclerosis.
The effect of involuntary job loss on smoking intensity and relapse.

AIMS To assess the impact of involuntary job loss due to plant closure or layoff on relapse to smoking and smoking intensity among older workers. DESIGN, PARTICIPANTS, SAMPLE: Data come from the Health and Retirement Study, a nationally representative survey of older Americans aged 51-61 in 1991 followed every 2 years beginning in 1992. The 3052 participants who were working at the initial wave and had any history of smoking comprise the main sample. METHODS Primary outcomes are smoking relapse at wave 2 (1994) among baseline former smokers, and smoking quantity at wave 2 among baseline current smokers. As reported at the wave 2 follow-up, 6.8% of the sample experienced an involuntary job loss between waves 1 and 2. FINDINGS Older workers have over two times greater odds of relapse subsequent to involuntary job loss than those who did not. Further, those who were current smokers prior to displacement that did not obtain new employment were found to be smoking more cigarettes, on average, post-job loss. CONCLUSIONS The stress of job loss, along with other significant changes associated with leaving one's job, which would tend to increase cigarette consumption, must outweigh the financial hardship which would tend to reduce consumption. This highlights job loss as an important health risk factor for older smokers.
Base Rates, Deception Detection, and Deception Theory: A Reply to Burgoon (2015)

This essay continues a debate about the relative scientific merits of the Park-Levine Model (PLM) and Interpersonal Deception Theory (IDT) with regard to accuracy in deception detection. Key points of disagreement include (a) the degree to which message recipients are sensitive to sender veracity and (b) the extent to which interactivity moderates the veracity and base-rate effects specified by PLM. According to PLM, people are truth-biased, truth-bias makes people insensitive to deception, and as a consequence, base rates affect accuracy regardless of interactivity. IDT, in direct contrast, holds that people are sensitive to the veracity of other's communication and that interactivity is a key moderator. Consistent with PLM, data repeatedly show that people are insensitive to other's veracity and that this insensitivity is general across media affordances including interactivity. This rejoinder uses Burgoon's (2015) own interactive data to demonstrate the empirical superiority of PLM over IDT.
A phase II trial of a multi-agent oral antiangiogenic (metronomic) regimen in children with recurrent or progressive cancer

Preclinical models show that an antiangiogenic regimen at low‐dose daily (metronomic) dosing may be effective against chemotherapy‐resistant tumors. We undertook a prospective, open‐label, single‐arm, multi‐institutional phase II study to evaluate the efficacy of a “5‐drug” oral regimen in children with recurrent or progressive cancer.
Left heart disease: a frequent cause of early pulmonary hypertension in systemic sclerosis, unrelated to elevated NT-proBNP levels or overt cardiac fibrosis but associated with increased levels of MR-proANP and MR-proADM: retrospective analysis of a French Canadian cohort

Objectives: Pulmonary hypertension (PH) causes mortality in systemic sclerosis (SSc). Pulmonary arterial hypertension (PAH) and left heart disease (LHD) are frequent causes of PH. Therefore, we studied PAH and LHD in early PH. Method: A total of 432 French Canadian SSc patients were studied retrospectively. All underwent screening for PH. We analysed clinical, serological, and radiographic data from 26 patients with early PH diagnosed by right heart catheterization (RHC). SSc patients with (n = 21) and without PH (n = 19) were prospectively re-evaluated by cardiac magnetic resonance imaging (MRI) and serial measurements of N-terminal pro-brain natriuretic peptide (NT-proBNP) and the haemodynamic biomarkers mid-regional pro-atrial natriuritic peptide (MR-proANP) and mid-regional pro-adrenomedullin (MR-proADM). Results: The most frequent cause of early PH was LHD (58%). PAH was seen in 34% of patients. No association was found between the type of PH and autoantibodies. Early LHD-PH, but not early PAH, was associated with lower NT-proBNP (p = 0.024), but MR-proANP and MR-proADM levels were higher in early LHD-PH than in patients without PH (p = 0.014 and p = 0.012, respectively). Only one patient had abnormal cardiac MRI explaining LHD-PH. Conclusions: Early PH in SSc, like late PH, is heterogeneous and RHC is essential for determining its underlying cause. The most frequent cause of early PH was LHD. Levels of MR-proANP and MR-proADM, but not NT-proBNP, were increased in early LHD-PH, and may be more reliable than NT-proBNP as a biomarker of early PH in this subgroup of patients. Cardiac MRI did not explain LHD-PH. This study is the first to identify a high frequency of LHD in early PH correlating with normal NT-proBNP levels but increased MR-proANP and MR-proADM levels in SSc patients.
A longitudinal phenomenological analysis of coping effectiveness among Scottish international adolescent golfers

Abstract The aim of this study was to explore coping effectiveness among international golfers. Five Scottish international adolescent golfers (mean age 16.6 years, s = 0.6) maintained daily coping effectiveness diaries over a 28-day period during their competitive season. Data were thematically analysed using interpretive phenomenological analysis (Smith & Osborn, 2003). The participants reported 56 effective coping strategies and 23 ineffective coping strategies. The unique finding from this study is that the same coping strategies were often rated as being both effective and ineffective, even when they were employed to manage the same stressor. This suggests that the goodness-of-fit approach and the choice of coping strategy theories may not be adequate explanations of coping effectiveness. Applied practitioners working with golfers are encouraged to teach their clients a variety of coping strategies, which should be deployed in combination.
Out in Africa: Queer Desire in Some Anthropological and Literary Texts1

We need to criss-cross queer theory with postcoloniality, in order to examine the phenomenon of those who are ‘out in Africa’. To date there have been only embryonic attempts to consider the literary representation of same-sex desire in a pan-African context.2 What is more, we lack a comparative approach to queer studies of African literatures, for research remains split between anglophone and francophone, let alone lusophone, studies, patterned on the colonial carving up of the African continent. Research has also privileged the colonial over the postcolonial period and male over female intimacies.3 It has therefore become crucial to identify those literary texts that present, in a subterranean way, homosexuality-as-an-identity rather than an occasional or ritualized practice, as was the case in the early ethnographic imagination. I have therefore attempted to place my analysis in the historical context of the dominant anthropological discourse and to sketch out an evolutionary pattern in representing male and female samesex desire in the novel while confining my scope to sub-Saharan Africa, even if Islamic homosexualities in the Maghreb and the Mashreq need to be addressed as well.4 Homosexuality is still thought to be not only ‘un-African’ but also a highly suspicious import from the deviant West. As a case in point, in the wake of the trial for sodomy of the first president of Zimbabwe, Canaan Banana, his successor Robert Mugabe spoke of homosexuals in his 2002 electioneering speech as ‘mad person[s]’ who will be sent to jail: ‘we don’t want to import it [homosexuality] to our country [Zimbabwe], we have our own culture, our own people’. 5 Whereas Dennis Altman contended
Bringing Space Science Down to Earth for Preservice Elementary Teachers

This article reports on a collaborative enterprise between Oklahoma State University’s (OSU) NASA Education Projects and OSU’s College of Education preservice elementary teachers (PSTs) to engage approximately 400 middle school students for a 20-minute live downlink with Commander Kevin Ford from the International Space Station (ISS). NASA supports this opportunity through a competitive proposal process (National Aeronautics and Space Administration, 2014). The project’s theme, Pioneers in Space: STEM Careers on the Space Frontier, engaged both PSTs and middle school students in discussing the benefits of space research, while drawing on themes relevant to students’ regional history. PSTs prepared Pioneers in Space instructional units and led classroom activities linking 6th grade state science standards. The desired outcome was to promote a greater understanding of how space exploration benefits society and contributes to STEM innovations. This paper reports on how curriculum design and leadership experiences in space education and outreach impacted the PST participants.
Differential Social and Academic Effects of Developmentally Appropriate Practices and Beliefs

Abstract This investigation examined the prevalence of developmentally appropriate practices in the primary grades and the effects of teachers' developmentally appropriate beliefs and practices on 1st-grade students' social skills and academic achievement in the areas of language and mathematics. The participants were 293 first-grade students attending four inner-city public schools and their teachers. An instrument was administered to the teachers in order to measure the degree to which their beliefs and instructional practices reflect the tenets of developmentally appropriate practices. Academic achievement tests were administered to the 1st-grade students, and their social behavior was assessed using the Social Skills Rating Scale (Gresham & Elliott, 1990). The analyses examined differences in the academic achievement and social skills of students who were taught by teachers whose beliefs and practices were consistent with developmentally appropriate practices, developmentally inappropriate practices, .
Eccentric bus-bar testing method of the shielding effect of heavy current transformer with shielding coils

To equivalently test the shielding effect of heavy current transformer (HCT) with shielding coils in laboratory, an eccentric bus-bar testing method has been used to simultaneously simulate the effect of the primary bus-bar and adjacent bus-bar since 1970s. But still there hasn't been an effective way to determine the crucial parameters, especially the eccentric distance, which means the distance from the center of the eccentric bus-bar to the center of HCT. This paper presents several analytical formulas to determine the eccentric distance and relevant parameters in the testing method, which may overcome the present difficulty. The formulas are derived from magnetic circuit model, and further verified by finite element method (FEM). Numerical results show that these formulas are effective and easy to use in the testing of HCT. Further more, if the eccentric current, which should be equal to the original primary current, is still too high to reproduce in laboratory, auxiliary and compensating windings could be adopted to reduce it.
Getting Along with Teachers and Parents: The Yields of Good Relationships for Students' Achievement Motivation and Self-Esteem

Abstract The aim of the present study was to better understand the combined and unique effects of teacher–student and parent–child relationships in students' achievement motivation and self-esteem. Participants were 3450 high school students administered items assessing their interpersonal relationships, academic motivation and engagement, academic self-concept, and general self-esteem. Preliminary correlations showed that both teacher–student and parent–child relationships are significantly associated with achievement motivation and general self-esteem. Importantly, however, when using appropriate structural equation models to control for shared variance amongst predictors, findings showed that although teachers and parents are clearly influential, after controlling for gender, age, and the presence of both interpersonal relationships in the one model, teacher effects are stronger than parent effects, particularly in the academic domain.
Arx: A Strongly Encrypted Database System

In recent years, encrypted databases have emerged as a promising direction that provides data conﬁdentiality without sacriﬁcing functionality: queries are executed on encrypted data. However, existing practical proposals rely on a set of weak encryption schemes that have been shown to leak sensitive data. In this paper, we propose Arx, the ﬁrst practical and functionally rich database system that encrypts the data only with strong encryption schemes. Arx protects the database with the same level of security as regular AES-based encryption, which by itself is devoid of functionality. We show that Arx supports real applications such as ShareLatex and a health data cloud provider, and that its performance overhead is modest.
Persistent Residual Errors in Motor Adaptation Tasks: Reversion to Baseline and Exploratory Escape

When movements are perturbed in adaptation tasks, humans and other animals show incomplete compensation, tolerating small but sustained residual errors that persist despite repeated trials. State-space models explain this residual asymptotic error as interplay between learning from error and reversion to baseline, a form of forgetting. Previous work using zero-error-clamp trials has shown that reversion to baseline is not obligatory and can be overcome by manipulating feedback. We posited that novel error-clamp trials, in which feedback is constrained but has nonzero error and variance, might serve as a contextual cue for recruitment of other learning mechanisms that would then close the residual error. When error clamps were nonzero and had zero variance, human subjects changed their learning policy, using exploration in response to the residual error, despite their willingness to sustain such an error during the training block. In contrast, when the distribution of feedback in clamp trials was naturalistic, with persistent mean error but also with variance, a state-space model accounted for behavior in clamps, even in the absence of task success. Therefore, when the distribution of errors matched those during training, state-space models captured behavior during both adaptation and error-clamp trials because error-based learning dominated; when the distribution of feedback was altered, other forms of learning were triggered that did not follow the state-space model dynamics exhibited during training. The residual error during adaptation appears attributable to an error-dependent learning process that has the property of reversion toward baseline and that can suppress other forms of learning.
Of Mother Tongues and Other Tongues: The Stakes of Linguistically Inclusive Pedagogy in Minority Contexts

This article addresses two key challenges that globalization poses to literacy research: the need for new models of literacy and literacy education, and the stakes of adopting multiliteracies pedagogies in different contexts – that is, the tensions between competing hegemonic discourses of collective identity in the public sphere of ethnolinguistic minority societies that are sparked when globalization destabilizes monocultural institutional practices. I explore the stakes of multiliteracies practice within Québec, an increasingly poly-ethnic white settler society and proto-nation whose minority ethnonational project has been launched on the very terrain of federal multiculturalism within a bilingual framework and provincial interculturalism within a monolingual framework. The article reports on a qualitative study of teacher discourse following collaborative multiliteracies curriculum development in an ethnolinguistically diverse English-language Montréal elementary school. It focuses on the shifting conceptions of multilingual and academic literacies articulated as teachers bring the 'lens of the personal' to negotiate competing values and identities implicit in their emerging practice.
Examining the Origin of Posttransplant Lymphoproliferative Disorder in a Patient After a Second Allogeneic Hematopoeitic Stem Cell Transplantation for Relapsed BCR-ABL Positive Acute Lymphoblastic Leukemia

Background Posttransplant lymphoproliferative disease (PTLD) is a serious complication because of the reactivation of the Epstein-Barr virus (EBV). Although after solid organ transplantation (SOT) EBV is typically of recipient origin, after hematopoietic stem cell transplantation (HSCT) donor-derived B cells are usually the source of the EBV-induced lymphoproliferation. Observation We report a unique presentation of an EBV-associated PTLD in a 13-year-old boy who underwent 2 subsequent HSCTs from 2 different-sex donors for BCR-ABL-positive acute lymphoblastic leukemia (ALL) and relapses of leukemia, respectively. The PTLD tissue was analyzed for the origin of both B cells and T cells of the lesion. Chimerism analysis done with short tandem repeat systems (STR) showed no autologous signals; approximately 50% of the cells were from the first and second donors, respectively. XY–fluorescence in situ hybridization showed a B-cell PTLD originating from the first donor surrounded by T cells from the second donor. Conclusion This case shows that EBV-infected B cells from a first donor can be the source of a PTLD after a second myeloablative HSCT from a different donor.