Miracle-dz/UniFAR-FTUs huggingface dataset:
Curry-Howard Term Calculi for Gentzen-Style Classical Logics

This thesis is concerned with the extension of the Curry-Howard Correspondence to classical logic. Although much progress has been made in this area since the seminal paper by Griffin, we believe that the question of finding canonical calculi corresponding to classical logics has not yet been resolved. We examine computational interpretations of classical logics which we keep as close as possible to Gentzen’s original systems, equipped with general notions of reduction. We present a calculus X i which is based on classical sequent calculus and the stronglynormalising cut-elimination procedure defined by Christian Urban. We examine how the notion of shallow polymorphism à la ML can be adapted to this calculus. We show that the intuitive adaptation of these ideas fails to be sound, and give a novel solution. In the setting of classical natural deduction, we examine the λμ-calculus of Parigot. We show that the underlying logic is incomplete in various ways, compared with a standard Gentzen-style presentation of classical natural deduction. We relax the identified restrictions, yielding a richer calculus (νλμ) with a new kind of binding explicitly representing first-class continuations. We examine the relationship between various existing control operators in the literature and the νλμ-calculus. We show that the μ-binding, along with our generalised reduction rules, performs the role of a delimited control operator. We define a mapping from X i to νλμ, preserving typings and reductions. We believe this is the first time a general notion of cut-elimination for classical sequent calculus has been encoded into a calculus based on a Gentzen-style presentation of classical natural deduction. This encoding allows various of our results from the previous chapters to be adapted from one paradigm to the other.
Peginterferon alfa‐2a (40kDa) and ribavirin: comparable rates of sustained virological response in sub‐sets of older and younger HCV genotype 1 patients

Summary. The average age of patients initiating therapy for HCV is increasing, with older patients exhibiting lower responses to therapy than younger patients. Identification of those older patients likely to respond needs to be addressed. Using data from 569 genotype‐1 patients enrolled in two phase III studies (NV15801/NV15942) randomized to peginterferon alfa‐2a (40KDa) 180 μg/week plus ribavirin 1000/1200 mg/day for 48‐weeks, we investigated factors associated with sustained virological response (SVR; undetectable HCV‐RNA 24‐weeks post‐treatment) in patients >50 years. SVR rates among patients ≤50 was greater than those >50 years (52%vs 39%; P = 0.0073). Older patients with a rapid virological response (RVR; undetectable HCV‐RNA at treatment week 4) or complete early virological response (cEVR; detectable HCV‐RNA at week 4 but HCV‐RNA <50 IU/mL at week‐12) demonstrated high SVR rates (83% and 61% respectively). Older patients had lower cumulative peginterferon alfa‐2a exposure and significantly lower cumulative ribavirin exposure (252 g vs 304 g in younger patients; P < 0.0001). Higher relapse rates were observed in older patients (41%vs 25%; P = 0.0042). Cumulative drug exposure and achievement of RVR or cEVR were significantly predictive of SVR by multiple logistic regression analysis in patients >50 years. Other baseline characteristics predictive of SVR in those >50 years of age were lower baseline HCV‐RNA level (P = 0.0067), higher ALT‐ratio (P = 0.0113) and absence of cirrhosis (P = 0.0482). Response rates were high among patients >50 years without cirrhosis who maintained adequate drug exposure and those achieving an RVR or cEVR. More frequent dose modifications of ribavirin in those >50 years likely contributed to the observed higher relapse rates.
On The Robust Construction of Constrained Delaunay Tetrahedralizations

We present a simple and robust algorithm to construct the Constrained Delaunay Tetrahedralization(CDT) for a Piecewise Linear Complex(PLC). The algorithm is based on Si’s CDT [1] algorithm, but we provide a new facet recovery algorithm, which is simple and easy to implement. The implementation and robustness issues of the CDT algorithm are discussed in detail and the program which implements the algorithm is tested with several examples. The results are compared with TetGen [2] and demonstrate the robustness and efficiency of the algorithm.
Molecular Design and Functional Organization of the RecA Protein

ABSTRACT The bacterial RecA protein participates in a remarkably diverse set of functions, all of which are involved in the maintenance of genomic integrity. RecA is a central component in both the catalysis of recombinational DNA repair and the regulation of the cellular SOS response. Despite the mechanistic differences of its functions, all require formation of an active RecA/ATP/DNA complex. RecA is a classic allosterically regulated enzyme, and ATP binding results in a dramatic increase in DNA binding affinity and a cooperative assembly of RecA subunits to form an ordered, helical nucleoprotein filament. The molecular events that underlie this ATP-induced structural transition are becoming increasingly clear. This review focuses on descriptions of our current understanding of the molecular design and allosteric regulation of RecA. We present a comprehensive list of all published recA mutants and use the results of various genetic and biochemical studies, together with available structural information, to develop ideas regarding the design of RecA functional domains and their catalytic organization.
An Endogeneous Corpus-Based Method for Structural Noun Phrase Disambiguation

In this paper, we describe a method for structural noun phrase disambiguation which mainly relies on the examination of the text corpus under analysis and doesn't need to integrate any domain-dependent lexico- or syntactico-semantic information. This method is implemented in the Terminology Extraction Sottware LEXTER. We first explain why the integration of LEXTER in the LEXTER-K project, which aims at building a tool for knowledge extraction from large technical text corpora, requires improving the quality of the terminolgy extracted by LEXTER. Then we briefly describe the way LEXTER works and show what kind of disambiguation it has to perform when parsing "maximal-length" noun phrases. We introduce a method of disambiguation which relies on a very simple idea: whenever LEXTER has to choose among several competing noun sub-groups in order to disambiguate a maximal-length noun phrase, it checks each of these sub-groups if it occurs anywhere else in the corpus in a non-ambiguous situation, and then it makes a choice. The half-a-million words corpus analysis resulted in an efficient strategy of disambiguation. The average rates are:27% no disambiguation70% correct disambiguation3% wrong disambiguation
Efficient epoxidation of electron-deficient alkenes with hydrogen peroxide catalyzed by [γ-PW10O38V2(μ-OH)2]3-.

A divanadium-substituted phosphotungstate, [γ-PW(10)O(38)V(2)(μ-OH)(2)](3-) (I), showed the highest catalytic activity for the H(2)O(2)-based epoxidation of allyl acetate among vanadium and tungsten complexes with a turnover number of 210. In the presence of I, various kinds of electron-deficient alkenes with acetate, ether, carbonyl, and chloro groups at the allylic positions could chemoselectively be oxidized to the corresponding epoxides in high yields with only an equimolar amount of H(2)O(2) with respect to the substrates. Even acrylonitrile and methacrylonitrile could be epoxidized without formation of the corresponding amides. In addition, I could rapidly (≤10 min) catalyze epoxidation of various kinds of terminal, internal, and cyclic alkenes with H(2)O(2) under the stoichiometric conditions. The mechanistic, spectroscopic, and kinetic studies showed that the I-catalyzed epoxidation consists of the following three steps: 1) The reaction of I with H(2)O(2) leads to reversible formation of a hydroperoxo species [γ-PW(10)O(38)V(2)(μ-OH)(μ-OOH)](3-) (II), 2) the successive dehydration of II forms an active oxygen species with a peroxo group [γ-PW(10)O(38)V(2)(μ-η(2):η(2)-O(2))](3-) (III), and 3) III reacts with alkene to form the corresponding epoxide. The kinetic studies showed that the present epoxidation proceeds via III. Catalytic activities of divanadium-substituted polyoxotungstates for epoxidation with H(2)O(2) were dependent on the different kinds of the heteroatoms (i.e., Si or P) in the catalyst and I was more active than [γ-SiW(10)O(38)V(2)(μ-OH)(2)](4-). On the basis of the kinetic, spectroscopic, and computational results, including those of [γ-SiW(10)O(38)V(2)(μ-OH)(2)](4-), the acidity of the hydroperoxo species in II would play an important role in the dehydration reactivity (i.e., k(3)). The largest k(3) value of I leads to a significant increase in the catalytic activity of I under the more concentrated conditions.
Analysis of paternal lineages in Brazilian and African populations

The present-day Brazilian population is a consequence of the admixture of various peoples of very different origins, namely, Amerindians, Europeans and Africans. The proportion of each genetic contribution is known to be very heterogeneous throughout the country. The aim of the present study was to compare the male lineages present in two distinct Brazilian populations, as well as to evaluate the African contribution to their male genetic substrate. Thus, two Brazilian population samples from Manaus (State of Amazon) and Ribeirão Preto (State of São Paulo) and three African samples from Guinea Bissau, Angola and Mozambique were typed for a set of nine Y chromosome specific STRs. The data were compared with those from African, Amerindian and European populations. By using Y-STR haplotype information, low genetic distances were found between the Manaus and Ribeirão Preto populations, as well as between these and others from Iberia. Likewise, no significant distances were observed between any of the African samples from Angola, Mozambique and Guinea Bissau. Highly significant Rst values were found between both Brazilian samples and all the African and Amerindian populations. The absence of a significant Sub-Saharan African male component resulting from the slave trade, and the low frequency in Amerindian ancestry Y-lineages in the Manaus and Ribeirão Preto population samples are in accordance with the accentuated gender asymmetry in admixture processes that has been systematically reported in colonial South American populations.
Effect of Aggressive Warming versus Routine Thermal Management on the Incidence of Perioperative Hypothermia in Patients Undergoing Thyroid Surgery: A Prospective, Randomized, Double-Blind Controlled Trial

Purpose Despite the implementation of various insulation measures, the incidence of hypothermia during thyroid surgery remains high. This randomized controlled study aimed to evaluate the effects of aggressive thermal management combined with resistive heating mattresses to prevent perioperative hypothermia in patients undergoing thyroid surgery. Patients and Methods 142 consecutive patients scheduled for elective thyroid surgery were enrolled in the study. They were randomly and equally allocated to the aggressive warming or routine care groups (n = 71). The patients’ body temperature was monitored before the induction of anesthesia until they returned to the ward. The primary outcome was the incidence of perioperative hypothermia. Secondary outcomes included postoperative complications, such as mortality, cardiovascular complications, wound infection, shivering, postoperative nausea and vomiting (PONV), visual analog scale (VAS) pain scores, fever, headache and hospital length of stay (LOS). Results In our study, the results showed that a significantly higher rate of hypothermia was observed in the routine care group compared with the aggressive warming group. The incidence of perioperative hypothermia was 19.72% (14/71) in the aggressive warming group and 35.21% (25/71) in the routine care group (P < 0.05). The incidence of shivering in the aggressive warming group (1.41%) was significantly lower than that in the routine care group (11.27%) (P < 0.05), and a one-day reduction in hospital length of stay was observed in the aggressive warming group (P < 0.05). There was no significant difference in mortality or other postoperative complications, such as cardiovascular complications, wound infection, PONV, pain, fever or headache, between the two groups (P > 0.05). Conclusion Our results suggest that aggressive thermal management combined with resistive heating mattresses provided improved perioperative body temperature and reduced the incidence of perioperative hypothermia and shivering compared to routine thermal management.
Evaluation of plasma oxidative status in patients with slow coronary flow.

BACKGROUND Slow coronary flow (SCF) is a coronary microvascular disorder characterised by delayed opacification of coronary vessels in a normal coronary angiogram. Coronary endothelial dysfunction plays an important pathogenetic role in patients with SCF. Oxidative stress is associated with cardiovascular diseases. AIM To assess the total antioxidant capacity (TAC) and total oxidative status (TOS) in patients with SCF. METHODS The study included 36 patients with SCF. An age- and gender-matched control group was composed of 30 patients with normal coronary arteries and normal coronary flow. We measured plasma TAC and TOS levels and oxidative stress index(OSI) value in patients and control subjects. Linear regression analysis was performed to identify factors associated with the mean TIMI frame count (TFC). RESULTS Plasma TOS level and OSI value were significantly higher in the SCF group compared to the control group (p = 0.005 and p = 0.004, respectively). However, there was no significant difference in plasma TAC levels between the groups (p = 0.104). Factors associated with mean TFC were plasma TOS levels (β = 0.425, p = 0.002) and fasting glucose levels (β = 0.099, p = 0.01) in linear regression analysis. CONCLUSIONS We found that plasma TOS and OSI were significantly higher in SCF compared to the control group and plasma TOS levels were independently associated with mean TFC.
Joint optimization of bid and budget allocation in sponsored search

This paper is concerned with the joint allocation of bid price and campaign budget in sponsored search. In this application, an advertiser can create a number of campaigns and set a budget for each of them. In a campaign, he/she can further create several ad groups with bid keywords and bid prices. Data analysis shows that many advertisers are dealing with a very large number of campaigns, bid keywords, and bid prices at the same time, which poses a great challenge to the optimality of their campaign management. As a result, the budgets of some campaigns might be too low to achieve the desired performance goals while those of some other campaigns might be wasted; the bid prices for some keywords may be too low to win competitive auctions while those of some other keywords may be unnecessarily high. In this paper, we propose a novel algorithm to automatically address this issue. In particular, we model the problem as a constrained optimization problem, which maximizes the expected advertiser revenue subject to the constraints of the total budget of the advertiser and the ranges of bid price change. By solving this optimization problem, we can obtain an optimal budget allocation plan as well as an optimal bid price setting. Our simulation results based on the sponsored search log of a commercial search engine have shown that by employing the proposed method, we can effectively improve the performances of the advertisers while at the same time we also see an increase in the revenue of the search engine. In addition, the results indicate that this method is robust to the second-order effects caused by the bid fluctuations from other advertisers.
Thoracoscopy--state of the art.

"Medical" thoracoscopy as compared with "surgical" thoracoscopy (which is more precisely known as video-assisted thoracic surgery (VATS)) has the advantage that it can be performed under local anaesthesia or conscious sedation, in an endoscopy suite, using nondisposible rigid instruments. Thus, it is considerably less invasive and less expensive. The main diagnostic and therapeutic indications for medical thoracoscopy are pleural effusions and pneumothorax. Due to its high diagnostic accuracy, approaching almost 100% in malignant and tuberculous pleural effusions, it should be used when pleural fluid analysis and needle biopsy are nondiagnostic. In addition, medical thoracoscopy provides staging for lung cancer and diffuse malignant mesothelioma. Talc poudrage, as the best conservative method for pleurodesis in 1998, can also be performed with medical thoracoscopy. It can also be effectively used in the early management of empyema. In spontaneous pneumothorax it allows staging, thereby facilitating treatment decisions, and in addition coagulation of eventual blebs and talc poudrage for efficient pleurodesis. Medical thoracoscopy is a safe procedure which is even easier to learn than flexible bronchoscopy. Due to its high diagnostic and therapeutic efficiency, it should be applied increasingly in the management of the above-mentioned pleuropulmonary diseases.
Ribosomopathies: Global process, tissue specific defects

Disruptions in ribosomal biogenesis would be expected to have global and in fact lethal effects on a developing organism. However, mutations in ribosomal protein genes have been shown in to exhibit tissue specific defects. This seemingly contradictory finding - that globally expressed genes thought to play fundamental housekeeping functions can in fact exhibit tissue and cell type specific functions ‐ provides new insight into roles for ribosomes, the protein translational machinery of the cell, in regulating normal development and disease. Furthermore it illustrates the surprisingly dynamic nature of processes regulating cell type specific protein translation. In this review, we discuss our current knowledge of a variety of ribosomal protein mutations associated with human disease, and models to better understand the molecular mechanisms associated with each. We use specific examples to emphasize both the similarities and differences between the effects of various human ribosomal protein mutations. Finally, we discuss areas of future study that are needed to further our understanding of the role of ribosome biogenesis in normal development, and possible approaches that can be used to treat debilitating ribosomopathy diseases.
The Receptor Recycling Pathway Contains Two Distinct Populations of Early Endosomes with Different Sorting Functions

Receptor recycling involves two endosome populations, peripheral early endosomes and perinuclear recycling endosomes. In polarized epithelial cells, either or both populations must be able to sort apical from basolateral proteins, returning each to its appropriate plasma membrane domain. However, neither the roles of early versus recycling endosomes in polarity nor their relationship to each other has been quantitatively evaluated. Using a combined morphological, biochemical, and kinetic approach, we found these two endosome populations to represent physically and functionally distinct compartments. Early and recycling endosomes were resolved on Optiprep gradients and shown to be differentially associated with rab4, rab11, and transferrin receptor; rab4 was enriched on early endosomes and at least partially depleted from recycling endosomes, with the opposite being true for rab11 and transferrin receptor. The two populations were also pharmacologically distinct, with AlF4 selectively blocking export of transferrin receptor from recycling endosomes to the basolateral plasma membrane. We applied these observations to a detailed kinetic analysis of transferrin and dimeric IgA recycling and transcytosis. The data from these experiments permitted the construction of a testable, mathematical model which enabled a dissection of the roles of early and recycling endosomes in polarized receptor transport. Contrary to expectations, the majority (>65%) of recycling to the basolateral surface is likely to occur from early endosomes, but with relatively little sorting of apical from basolateral proteins. Instead, more complete segregation of basolateral receptors from receptors intended for transcytosis occurred upon delivery to recycling endosomes.
Feature-Based Textures

This paper introduces feature-based textures, a new image representation that combines features and samples for high-quality texture mapping. Features identify boundaries within an image where samples change discontinuously. They can be extracted from vector graphics representations, or explicitly added to raster images to improve sharpness. Texture lookups are then interpolated from samples while respecting these boundaries. We present results from a software implementation of this technique demonstrating quality, efficiency and low memory overhead.
Modulation of the Na,K-pump function by beta subunit isoforms

To study the role of the Na,K-ATPase beta subunit in the ion transport activity, we have coexpressed the Bufo alpha 1 subunit (alpha 1) with three different isotypes of beta subunits, the Bufo Na,K-ATPase beta 1 (beta 1NaK) or beta 3 (beta 3NaK) subunit or the beta subunit of the rabbit gastric H,K-ATPase (beta HK), by cRNA injection in Xenopus oocyte. We studied the K+ activation kinetics by measuring the Na,K- pump current induced by external K+ under voltage clamp conditions. The endogenous oocyte Na,K-ATPase was selectively inhibited, taking advantage of the large difference in ouabain sensitivity between Xenopus and Bufo Na,K pumps. The K+ half-activation constant (K1/2) was higher in the alpha 1 beta 3NaK than in the alpha 1 beta 1NaK groups in the presence of external Na+, but there was no significant difference in the absence of external Na+. Association of alpha 1 and beta HK subunits produced active Na,K pumps with a much lower apparent affinity for K+ both in the presence and in the absence of external Na+. The voltage dependence of the K1/2 for external K+ was similar with the three beta subunits. Our results indicate that the beta subunit has a significant influence on the ion transport activity of the Na,K pump. The small structural differences between the beta 1NaK and beta 3NaK subunits results in a difference of the apparent affinity for K+ that is measurable only in the presence of external Na+, and thus appears not to be directly related to the K+ binding site. In contrast, association of an alpha 1 subunit with a beta HK subunit results in a Na,K pump in which the K+ binding or translocating mechanisms are altered since the apparent affinity for external K+ is affected even in the absence of external Na+.
Resonant cyclotron scattering and Comptonization in neutron star magnetospheres

Resonant cyclotron scattering of the surface radiation in the magnetospheres of neutron stars may considerably modify the emergent spectra and impede efforts to constrain neutron star properties. Resonant cyclotron scattering by a non-relativistic warm plasma in an inhomogeneous magnetic field has a number of unusual characteristics. (i) In the limit of high resonant optical depth, the cyclotron resonant layer is half opaque, in sharp contrast to the case of non-resonant scattering. (ii) The transmitted flux is on average Compton up-scattered by ∼1 + 2βT, where βT is the typical thermal velocity in units of the velocity of light; the reflected flux has on average the initial frequency. (iii) For both the transmitted and reflected fluxes, the dispersion of intensity decreases with increasing optical depth. (iv) The emergent spectrum is appreciably non-Planckian while narrow spectral features produced at the surface may be erased. We derive semi-analytically modification of the surface Planckian emission due to multiple scattering between the resonant layers and apply the model to the anomalous X-ray pulsar 1E 1048.1 − 5937. Our simple model fits just as well as the ‘canonical’ magnetar spectra model of a blackbody plus power law.