Miracle-dz/UniFAR-FTUs huggingface dataset:
Parental influence on child change in physical activity during a family-based intervention for child weight gain prevention.

BACKGROUND This study examined the association between parent and child change in physical activity during a family-based intervention for child weight gain prevention. METHODS Daily step counts were recorded for parents and children in 83 families given a goal to increase activity by 2000 steps per day above baseline. Linear mixed effects models were used to predict child change in daily step counts from parental change in step counts. RESULTS Both maternal (P < .0001) and paternal (P < .0001) change in step counts for the current day strongly predicted child change in step counts for that day. On average, a child took an additional 2117.6 steps above baseline on days his or her mother met her goal versus 1175.2 additional steps when the mother did not meet her goal. The respective values were 1598.0 versus 1123.1 steps for fathers. Day of week moderated the maternal effect (P = .0019), with a larger impact on Saturday and Sunday compared with weekdays. A similar but nonsignificant pattern was observed for fathers. CONCLUSIONS Encouraging parents to increase physical activity, particularly on weekends, may be a highly effective way to leverage parental involvement in interventions to increase children's physical activity.
Exploring nature experiences of people with visual impairments / Vivir la naturaleza con una discapacidad visual

Abstract The positive psychological and physical health effects associated with exposure to natural environments are well recognized. However, previous research in this field has focused almost exclusively upon the visual aspects of the environment, largely ignoring the role of the other senses. This paper reassesses these findings by examining the role senses other than sight play in blind people’s experiences of natural environments. Six people with visual impairments were interviewed regarding their experience of natural environments; interview transcripts were analysed using thematic analysis. The analysis revealed that if the participants felt safe, they reported experiencing restorative effects in the majority of natural environments. Three main themes that contribute to an understanding of the processes involved in psychological restoration emerged: restoration, challenges, sources of experiences. Environmental restoration was reported by participants as being mostly experienced through sound and to a lesser extent through touch and smell.
Circadian blood pressure and heart rate rhythms in mice

Li, Ping, Steven H. Sur, Ralph E. Mistlberger, and Mariana Morris. Circadian blood pressure and heart rate rhythms in mice. Am. J. Physiol. 276 (Regulatory Integrative Comp. Physiol. 45): R500–R504, 1999. —The circadian pattern of mean arterial pressure (MAP) and heart rate (HR) was measured in C57BL mice with carotid arterial catheters. Cardiovascular parameters were recorded continuously with a computerized monitoring system at a sampling rate of 100 Hz. The tethered animals were healthy, showing stabilized drinking and eating patterns within 2 days of surgery and little loss of body weight. Analysis of the 24-h pattern of MAP and HR was conducted using data from 3–6 consecutive days of recording. A daily rhythm of MAP was evident in all mice, with group mean dark and light values of 101.4 6 7.3 and 93.1 6 2.9 mmHg, respectively. The group mean waveform was bimodal, with peak values evident early and late in the dark period, and a trough during the middle of the light period. The phase of maximum and minimum values showed low within-group variance. Mean heart rate was greater at night than during the day (561.9 6 22.7 vs. 530.3 6 22.3 beats/min). Peak values generally occurred at dark onset, and minimum values during the middle of both the dark and the light periods. We conclude that it is possible to perform measurements of circadian cardiovascular parameters in the mouse, providing new avenues for the investigation of genetic models.
Behavioural equivalences for fluid stochastic Petri nets

We propose fluid equivalences to compare and reduce behaviour of labeled fluid stochastic Petri nets (LFSPNs) while preserving their discrete and continuous properties. We define a linear-time relation of fluid trace equivalence and its branching-time counterpart, fluid bisimulation equivalence. Both fluid relations take into account the essential features of the LFSPNs behaviour: functional activity, stochastic timing and fluid flow. We consider the LFSPNs whose continuous markings have no influence to the discrete ones and whose discrete part is continuous time stochastic Petri nets. The underlying stochastic model for the discrete part of the LFSPNs is continuous time Markov chains (CTMCs). The performance analysis of the continuous part of LFSPNs is accomplished via the associated stochastic fluid models (SFMs). We show that fluid trace equivalence preserves average potential fluid change volume for the transition sequences of every certain length. We prove that fluid bisimulation equivalence preserves the aggregated probability functions: stationary probability mass for the underlying CTMC, as well as stationary fluid buffer empty probability, fluid density and distribution for the associated SFM. Hence, the equivalence guarantees identity of a number of discrete and continuous performance measures. Fluid bisimulation equivalence is then used to simplify the qualitative and quantitative analysis of LFSPNs via quotienting the discrete reachability graph and underlying CTMC. To describe the quotient associated SFM, the quotients of the probability functions are defined. We characterize logically fluid trace and bisimulation equivalences with two novel fluid modal logics $HML_{flt}$ and $HML_{flb}$, based on the Hennessy-Milner Logic HML. The application example of a document preparation system demonstrates the behavioural analysis via quotienting by fluid bisimulation equivalence.
Involvement of miRNAs in the Differentiation of Human Glioblastoma Multiforme Stem-Like Cells

Glioblastoma multiforme (GBM)-initiating cells (GICs) represent a tumor subpopulation with neural stem cell-like properties that is responsible for the development, progression and therapeutic resistance of human GBM. We have recently shown that blockade of NFκB pathway promotes terminal differentiation and senescence of GICs both in vitro and in vivo, indicating that induction of differentiation may be a potential therapeutic strategy for GBM. MicroRNAs have been implicated in the pathogenesis of GBM, but a high-throughput analysis of their role in GIC differentiation has not been reported. We have established human GIC cell lines that can be efficiently differentiated into cells expressing astrocytic and neuronal lineage markers. Using this in vitro system, a microarray-based high-throughput analysis to determine global expression changes of microRNAs during differentiation of GICs was performed. A number of changes in the levels of microRNAs were detected in differentiating GICs, including over-expression of hsa-miR-21, hsa-miR-29a, hsa-miR-29b, hsa-miR-221 and hsa-miR-222, and down-regulation of hsa-miR-93 and hsa-miR-106a. Functional studies showed that miR-21 over-expression in GICs induced comparable cell differentiation features and targeted SPRY1 mRNA, which encodes for a negative regulator of neural stem-cell differentiation. In addition, miR-221 and miR-222 inhibition in differentiated cells restored the expression of stem cell markers while reducing differentiation markers. Finally, miR-29a and miR-29b targeted MCL1 mRNA in GICs and increased apoptosis. Our study uncovers the microRNA dynamic expression changes occurring during differentiation of GICs, and identifies miR-21 and miR-221/222 as key regulators of this process.
Tuning the Optical Properties of Cesium Lead Halide Perovskite Nanocrystals by Anion Exchange Reactions

We demonstrate that, via controlled anion exchange reactions using a range of different halide precursors, we can finely tune the chemical composition and the optical properties of presynthesized colloidal cesium lead halide perovskite nanocrystals (NCs), from green emitting CsPbBr3 to bright emitters in any other region of the visible spectrum, and back, by displacement of Cl– or I– ions and reinsertion of Br– ions. This approach gives access to perovskite semiconductor NCs with both structural and optical qualities comparable to those of directly synthesized NCs. We also show that anion exchange is a dynamic process that takes place in solution between NCs. Therefore, by mixing solutions containing perovskite NCs emitting in different spectral ranges (due to different halide compositions) their mutual fast exchange dynamics leads to homogenization in their composition, resulting in NCs emitting in a narrow spectral region that is intermediate between those of the parent nanoparticles.
Regulation of the Subcellular Distribution of m4 Muscarinic Acetylcholine Receptors in Striatal Neurons In Vivo by the Cholinergic Environment: Evidence for Regulation of Cell Surface Receptors by Endogenous and Exogenous Stimulation

Our aim was to determine how the cholinergic environment influences, in vivo, the membrane abundance and the intracellular trafficking of the muscarinic receptor m4 (m4R). Immunohistochemistry at light and electron microscopic level was used to detect the subcellular localization of m4R in several populations of striatal cholinoceptive neurons, including cholinergic neurons and medium spiny neurons. (1) In control rats, in cholinergic neurons, m4R is mostly restricted to intracytoplasmic sites involved in its synthesis, especially endoplasmic reticulum. In contrast, m4R is preferentially located at the plasma membrane in cell bodies and dendritic shafts and spines of medium spiny neurons. The density of m4R was greater at the membrane of perikarya in patches (striatal areas with low acetylcholine activity) than in matrix (striatal areas with high acetylcholine activity). (2) Stimulation of muscarinic receptor with oxotremorine provokes translocation of m4R from the membrane to endosomes in perikarya and dendrites of medium spiny neurons but has no influence on the localization of m4R in the cytoplasm of cholinergic cell bodies. Our results suggest that the intraneuronal trafficking and the abundance of membrane-bound m4R in vivo is under regulation of the cholinergic environment. The m4R subcellular compartmentalization depends on the phenotype of the cholinoceptive neuron and on its neurochemical environment. Such regulation, by modulating availability of receptor for endogenous and exogenous ligands, may play key roles in the response of target neurons.
H2S generation and Eh reduction in cysteine challenge testing as a means of determining the potential of test products and treatments for inhibiting oral malodor

Bacterial degradation of the sulfur-containing amino acid, cysteine, involves two biochemical processes that contribute significantly to oral malodor generation. The first is production of hydrogen sulfide, a major component and common indicator of oral malodor formation. The second is generation of the sulfhydryl anion, HS−, an anion that is central to the lowering of the oxidation–reduction potential (Eh). A reduced Eh is fundamental to the growth and metabolism of the oral Gram negative anaerobic bacteria. These microorganisms are responsible for oral putrefaction, a process primary to both oral malodor generation and gingivitis–periodontitis development. One purpose of this paper is to report on the testing of a number of anti-malodor treatments and products for their effects on H2S formation and Eh reduction, two processes that occur rapidly and do so simultaneously after the oral bacteria are challenged with cysteine. A second is to report on aspects of cysteine challenge testing in the development of an anti-malodor product composed of ZnCl2 and sodium chlorite that simultaneously inhibits both H2S formation and Eh reduction and effectively inhibits oral malodor.
Comment on “Dilution limits dissolved organic carbon utilization in the deep ocean”

Arrieta et al. (Reports, 17 April 2015, p. 331) propose that low concentrations of labile dissolved organic carbon (DOC) preclude prokaryotic consumption of a substantial fraction of DOC in the deep ocean and that this dilution acts as an alternative mechanism to recalcitrance for long-term DOC storage. Here, we show that the authors’ data do not support their claims.
Timing , Sequencing and Quantum of Life Course Events : a Machine Learning Approach

In this paper we discuss and apply machine learning techniques, using ideas from a core research area in the artificial intelligence literature to analyse simultaneously timing, sequencing, and quantum of life course events from a comparative perspective. We outline the need for techniques which allow the adoption of a holistic approach to life course analysis, illustrating the specific case of the transition to adulthood. We briefly introduce machine learning algorithms to build decision trees and rule sets and then apply such algorithms to delineate the key features which distinguish Austrian and Italian pathways to adulthood, using Fertility and Family Survey data. The key role of sequencing and synchronization between events emerges clearly from the analysis.
Use of drugs with anticholinergic effects and cognitive impairment in community-living older persons.

‘Acopia’ is a pejorative term describing the older patient who is ‘unable to cope’. This study assessed the characteristics of patients presenting with ‘acopia’ to a district general hospital in the United Kingdom. Nearly half of ‘acopia’ patients presented with geriatric syndromes such as falls and confusion. Redefining ‘acopia’ as an all-encompassing term to describe the frail older patient with multiple medical problems may help identify patients in need of urgent specialist geriatric input.
The Hidden Lives of Middle Schoolers.

ullying, drug use, sex—curious about whether or not these newsmaking trends describe your middle school students? And if so, how do they affect your classroom? We asked Linda Perlstein, a reporter who spent a year attending classes at Wilde Lake Middle School in Maryland. Perlstein witnessed a side of middle school that teachers rarely get to see. “The kids asked me to read their diaries, invited me to their parties,” she says. As she does in Not Much Just Chillin’: The Hidden Lives of Middle Schoolers (Ballantine, 2004), Perlstein offered some fresh insights on teaching, respect, and life inside middle school.
Job insecurity, burnout and organisational commitment among employees of a financial institution in Gauteng

The objective of this study was to investigate the relationship between job insecurity, burnout and organisational commitment of human resource workers (N = 146) in a financial institution. A cross-sectional survey design was used. The Job Insecurity Questionnaire, Maslach Burnout Inventory-General Survey, Organisational Commitment Questionnaire and a biographical questionnaire were administered. Job insecurity demonstrated a relationship with increased levels of burnout and decreased levels of organisational commitment. Job insecurity was found to hold predictive value with regard to exhaustion, cynicism, and reduced professional efficacy, as well as reduced affective and normative commitment (while controlling for the influence of background variables). Opsomming Die doelstelling van hierdie navorsing was om die verhouding tussen werksonsekerheid, uitbranding en organisasie verbondenheid van menslike hulpbronwerknemers (N = 146) in ’n finansiele instelling te ondersoek. ’n Dwarsneeopname-ontwerp is gebruik. Die Werksonsekerheidvraelys, Maslach Uitbrandingvraelys, Organisasieverbondenheidvraelys en ’n biografiese vraelys is afgeneem. Werksonsekerheid het ’n verband met verhoogde vlakke van uitbranding en verlaagde vlakke van organisasie verbondenheid getoon. Daar is bevind dat werksonsekerheid voorspellingswaarde inhou vir uitputting, sinisme en verminderde professionele doeltreffendheid, sowel as verminderde affektiewe en normatiewe organisasieverbondenheid (terwyl daar gekontroleer is vir die invloed van demografiese verskille).
Oestrogen and progesterone receptor status of individual foci in multifocal invasive ductal breast cancer

Widespread acceptance of breast conserving surgery for early breast cancer has led to renewed interest in multifocality, which is seen in 13–63% of breast cancers. According to current guidelines, oestrogen/progesterone receptor status is assessed on the sample obtained at initial core biopsy or the main tumour focus in multifocal breast cancer (more than one distinct tumour focus in a quadrant). We assessed receptor status of individual foci in multifocal breast cancer. Mastectomy specimens for 18 cases of multifocal breast cancer were identified. Immunohistochemical staining for oestrogen and progesterone receptors was performed on all tumour foci. On histological examination 11 patients demonstrated two independent tumour foci, three demonstrated three foci and four demonstrated four foci. Minor differences in oestrogen receptor score were seen between foci (attributed to the subjective nature of the scoring system), which did not affect the overall positive/negative classification. Sixteen patients (88%) were oestrogen receptor-positive. Progesterone receptor staining showed more variability between foci in two patients but, since the tumours were oestrogen receptor-positive this would not have affected clinical decision-making. No major differences in oestrogen receptor status between multiple tumour foci in the same quadrant were found in this pilot study.
Antibody Testing and Lyme Disease Risk

Lyme disease test results for >9,000 dogs were collected from participating veterinary clinics. Testing was conducted by using the IDEXX 3Dx kit, used widely by Maine veterinarians to screen clinically normal dogs during heartworm season. This study demonstrates how this test can be a valuable public health disease surveillance tool.
Homeward Bound? Searching for home in Inner Sydney's share houses

Abstract Share house living arrangements are increasingly popular for young Australians as a result of a variety of economic and social changes such as the declining affordability of home ownership and delayed and decreasing marriage rates. Despite this rise, share housing is little researched. This paper considers the idea of ‘home’ as it exists in Inner Sydney's share houses, by examining the motivations underlying the decision to live in a share house as well as the relationships between housemates, in a sample of households. Share housing was utilised mainly as a response to social factors, such as the attraction of the lifestyle and something of a rite of passage, but was also shaped by economic considerations. Share housing was viewed by most people as transitional yet still meaningful. The vast majority considered their current dwelling to be ‘home’, mainly as a result of the intimacy of relationships between housemates, and the attainment of a sense of comfort and equality.
RNA Sequencing Reveals a Slow to Fast Muscle Fiber Type Transition after Olanzapine Infusion in Rats

Second generation antipsychotics (SGAs), like olanzapine, exhibit acute metabolic side effects leading to metabolic inflexibility, hyperglycemia, adiposity and diabetes. Understanding how SGAs affect the skeletal muscle transcriptome could elucidate approaches for mitigating these side effects. Male Sprague-Dawley rats were infused intravenously with vehicle or olanzapine for 24h using a dose leading to a mild hyperglycemia. RNA-Seq was performed on gastrocnemius muscle, followed by alignment of the data with the Rat Genome Assembly 5.0. Olanzapine altered expression of 1347 out of 26407 genes. Genes encoding skeletal muscle fiber-type specific sarcomeric, ion channel, glycolytic, O2- and Ca2+-handling, TCA cycle, vascularization and lipid oxidation proteins and pathways, along with NADH shuttles and LDH isoforms were affected. Bioinformatics analyses indicate that olanzapine decreased the expression of slower and more oxidative fiber type genes (e.g., type 1), while up regulating those for the most glycolytic and least metabolically flexible, fast twitch fiber type, IIb. Protein turnover genes, necessary to bring about transition, were also up regulated. Potential upstream regulators were also identified. Olanzapine appears to be rapidly affecting the muscle transcriptome to bring about a change to a fast-glycolytic fiber type. Such fiber types are more susceptible than slow muscle to atrophy, and such transitions are observed in chronic metabolic diseases. Thus these effects could contribute to the altered body composition and metabolic disease olanzapine causes. A potential interventional strategy is implicated because aerobic exercise, in contrast to resistance exercise, can oppose such slow to fast fiber transitions.
Effects of two Error-Correction Procedures on Oral Reading

An alternating-treatments design was used to investigate the relative effectiveness of two error-correction procedures, word supply and phonic analysis, on the oral reading performance of five elementary-school learning disabled students, four boys and one girl. All subjects had deficient oral reading skills. Results indicated that (a) increased oral reading rates were related to systematic correction procedures, and (b) the word-supply procedure was relatively superior to the phonic analysis method. Possible reasons for these findings are discussed, as are suggestions for future investigations and implications for instruction.
Bloodhound: Searching Out Malicious Input in Network Flows for Automatic Repair Validation

Many current systems security research efforts focus on mechanisms for Intrusion Prevention and Self-Healing Software. Unfortunately, such systems find it difficult to gain traction in many deployment scenarios. For self-healing techniques to be realistically employed, system owners and administrators must have enough confidence in the quality of a generated fix that they are willing to allow its automatic deployment. In order to increase the level of confidence in these systems, the efficacy of a ’fix’ must be tested and validated after it has been automatically developed, but before it is actually deployed. Due to the nature of attacks, such verification must proceed automatically. We call this problem Automatic Repair Validation (ARV). As a way to illustrate the difficulties faced by ARV, we propose the design of a system, Bloodhound, that tracks and stores malicious network flows for later replay in the validation phase for self-healing software.