Miracle-dz/UniFAR-FTUs huggingface dataset:
The relationship between user query accuracy and lines of code

In experimental studies on query languages, subjects are required to write queries using different query languages. User query performance is usually measured by query accuracy. There is no clearly defined objective method of applying findings to other queries. This study examines the suitability of using a software metric based on lines of code to estimate user query accuracy. Lines of code have been measured in various ways, such as physical source code lines, logical source code lines or compiled bytes. A method of counting lines of code for database queries is proposed and applied to two query languages. The new method counts Boolean conditions as well as other statements. The relationship between lines of code and user query accuracy was examined with regression models. The results show that lines of code can explain a high percentage of the variance in accuracy, with R2>0.8 for the standard relational model query language SQL, and R2>0.9 for the entity relationship model query language KQL. The common assumption that more lines of code will lead to lower accuracy is only partly validated. The findings show a nonlinear relationship, with a possible recovery in accuracy for queries with many lines of code. The results indicate that lines of code can be usefully applied in the study of query languages.
SKOS concepts and natural language concepts: An analysis of latent relationships in KOSs

The vehicle to represent Knowledge Organisation Systems (KOSs) in the environment of the Semantic Web and linked data is the Simple Knowledge Organisation System (SKOS). SKOS provides a way to assign a Uniform Resource Identifier (URI) to each concept, and this URI functions as a surrogate for the concept. This fact makes of main concern the need to clarify the URIs’ ontological meaning. The aim of this study is to investigate the relationship between the ontological substance of KOS concepts and concepts revealed through the grammatical and syntactic formalisms of natural language. For this purpose, we examined the dividableness of concepts in specific KOSs (i.e. a thesaurus, a subject headings system and a classification scheme) by applying Natural Language Processing (NLP) techniques (i.e. morphosyntactic analysis) to the lexical representations (i.e. RDF literals) of SKOS concepts. The results of the comparative analysis reveal that, despite the use of multi-word units, thesauri tend to represent concepts in a way that can hardly be further divided conceptually, while subject headings and classification schemes – to a certain extent – comprise terms that can be decomposed into more conceptual constituents. Consequently, SKOS concepts deriving from thesauri are more likely to represent atomic conceptual units and thus be more appropriate tools for inference and reasoning. Since identifiers represent the meaning of a concept, complex concepts are neither the most appropriate nor the most efficient way of modelling a KOS for the Semantic Web.
Divergent differentiation paths in airway smooth muscle culture: induction of functionally contractile myocytes.

We tested the hypothesis that prolonged serum deprivation would allow a subset of cultured airway myocytes to reacquire the abundant contractile protein content, marked shortening capacity, and elongated morphology characteristic of contractile cells within intact tissue. Passage 1 or 2 canine tracheal smooth muscle (SM) cells were grown to confluence, then serum deprived for up to 19 days. During serum deprivation, two differentiation pathways emerged. One-sixth of the cells developed an elongated morphology and aligned into bundles. Elongated myocytes contained cables of contractile myofilaments, dense bodies, gap junctions, and membrane caveoli, ultrastructural features of contractile SM in tissue. These cells immunostained intensely for SM α-actin, SM myosin heavy chain (MHC), and SM22 (an SM-specific actin-binding protein), and Western analysis of culture lysates disclosed 1.8 (SM α-actin)-, 7.7 (SM MHC)-, and 5.8 (SM22)-fold protein increases during serum deprivation. Immunoreactive M3 muscarinic receptors were present in dense foci distributed throughout elongated, SM MHC-positive myocytes. ACh (10-3 M) induced a marked shortening (59.7 ± 14.4% of original length) in 62% of elongated myocytes made semiadherent by gentle proteolytic digestion, and membrane bleb formation (a consequence of contraction) occurred in all stimulated cells that remained adherent and so did not shorten. Cultured airway myocytes that did not elongate during serum deprivation instead became short and flattened, lost immunoreactivity for contractile proteins, lacked the M3 muscarinic-receptor expression pattern seen in elongated cells, and exhibited no contractile response to ACh. Thus we demonstrate that prolonged serum deprivation induces distinct differentiation pathways in confluent cultured tracheal myocytes and that one subpopulation acquires an unequivocally functional contractile phenotype in which structure and function resemble contractile myocytes from intact tissue.
Area Preserving Cartographic Line Generalizaton

Pod kartografskom generalizacijom linija podrazumijeva se ona koja ima prvenstvenu namjenu dobivanje takvog oblika linija koji je pogodan za prikaz na kartama sitinijeg mjerila od mjerila zadanih linija. Osim takve generalizacije postojeca literatura razlikuje i modelnu generalizaciju i geografsku generalizaciju koje imaju i odgovarajucu namjenu. U radu je opisan novi algoritam za kartografsku generalizaciju linija koji ima svojstvo cuvanja povrsina. Osim svojstva cuvanja povrsina, algoritam daje generalizirane linije koje se opcenito sastoje od podskupa polaznih tocaka i skupa novih tocaka. Zbog toga se algoritam može smatrati kombinacijom pojednostavljenja i izglađivanja. Svojstvo ocuvanja povrsina rjeđe je zastupljeno u istraživanjima kartografske generalizacije linija. Težina takvih istraživanja usmjerena je prema obliku linije. U radu je detaljno opisan novi algoritam te su dani rezultati primjene novog algoritma na primjeru obalnih crta te usporedba s rucnom generalizacijom, Douglas-Peuckerovim algoritmom za pojednostavljenje, Boyleovim algoritmom za izglađivanje i kombinacijom posljednja dva algoritma. Testovi pokazuju da algoritam daje zadovoljavajuce rezultate u smislu kartografske generalizacije, a svojstvo ocuvanja povrsina istice se kao posebno pogodno za primjenu u GIS-u kada se atributi prikazuju ili analiziraju u odnosu na povrsine objekata.
Temporal Planning in Domains with Linear Processes

We consider the problem of planning in domains with continuous linear numeric change. Such change cannot always be adequately modelled by discretisation and is a key facet of many interesting problems. We show how a forward-chaining temporal planner can be extended to reason with actions with continuous linear effects. We extend a temporal planner to handle numeric values using linear programming. We show how linear continuous change can be integrated into the same linear program and we discuss how a temporal-numeric heuristic can be used to provide the search guidance necessary to underpin continuous planning. We present results to show that the approach can effectively handle duration-dependent change and numeric variables subject to continuous linear change.
Dueling algorithms

We revisit classic algorithmic search and optimization problems from the perspective of competition. Rather than a single optimizer minimizing expected cost, we consider a zero-sum game in which a search problem is presented to two players, whose only goal is to outperform the opponent. Such games are typically exponentially large zero-sum games, but they often have a rich structure. We provide general techniques by which such structure can be leveraged to find minmax-optimal and approximate minmax-optimal strategies. We give examples of ranking, hiring, compression, and binary search duels, among others. We give bounds on how often one can beat the classic optimization algorithms in such duels.
Automatic photo-to-terrain alignment for the annotation of mountain pictures

We present a system for the annotation and augmentation of mountain photographs. The key issue resides in the registration of a given photograph with a 3D geo-referenced terrain model. Typical outdoor images contain little structural information, particularly mountain scenes whose aspect changes drastically across seasons and varying weather conditions. Existing approaches usually fail on such difficult scenarios. To avoid the burden of manual registration, we propose a novel automatic technique. Given only a viewpoint and FOV estimates, the technique is able to automatically derive the pose of the camera relative to the geometric terrain model. We make use of silhouette edges, which are among most reliable features that can be detected in the targeted situations. Using an edge detection algorithm, our technique then searches for the best match with silhouette edges rendered using the synthetic model. We develop a robust matching metric allowing us to cope with the inevitable noise affecting detected edges (e.g. due to clouds, snow, rocks, forests, or any phenomenon not encoded in the digital model). Once registered against the model, photographs can easily be augmented with annotations (e.g. topographic data, peak names, paths), which would otherwise imply a tedious fusion process. We further illustrate various other applications, such as 3D model-assisted image enhancement, or, inversely, texturing of digital models.
Herbaceous Vascular Flora Of Forested Seep Wetlands In Winneshiek County, Iowa, USA

Forested seep wetlands dominated by skunk cabbage (Symplocarpus foetidus) occur frequently in the Canoe Creek watershed of the Upper Iowa River, but this type of wetland has not been described systematically in the upper Midwest. The goal of this study is to document the herbaceous plant flora of five seeps. Although individual seeps are small (200-500 m2), they provide habitat for a high number of plant species. Five seeps with total area less than 0.2 ha supported more than 120 native vascular herbaceous taxa, 20 of which have a coefficient of conservatism (C-value) of 7 or higher and 23 that are obligate wetland species. Several species that were common in these habitats 100 years ago appear to have been locally extirpated or have become uncommon in the region, including Gentianopsis crinita, Cirsium muticum, Eupatorium altissimum, Chelone glabra, and Micranthes pensylvanica. Today, these plant communities are threatened by invasive plant species, high levels of deer herbivory, and destruction by human.
Pulmonary alveolar proteinosis caused by deletion of the GM-CSFRα gene in the X chromosome pseudoautosomal region 1

Pulmonary alveolar proteinosis (PAP) is a rare lung disorder in which surfactant-derived lipoproteins accumulate excessively within pulmonary alveoli, causing severe respiratory distress. The importance of granulocyte/macrophage colony-stimulating factor (GM-CSF) in the pathogenesis of PAP has been confirmed in humans and mice, wherein GM-CSF signaling is required for pulmonary alveolar macrophage catabolism of surfactant. PAP is caused by disruption of GM-CSF signaling in these cells, and is usually caused by neutralizing autoantibodies to GM-CSF or is secondary to other underlying diseases. Rarely, genetic defects in surfactant proteins or the common β chain for the GM-CSF receptor (GM-CSFR) are causal. Using a combination of cellular, molecular, and genomic approaches, we provide the first evidence that PAP can result from a genetic deficiency of the GM-CSFR α chain, encoded in the X-chromosome pseudoautosomal region 1.
CD24 Expression Identifies Teratogen-Sensitive Fetal Neural Stem Cell Subpopulations: Evidence from Developmental Ethanol Exposure and Orthotopic Cell Transfer Models

Background Ethanol is a potent teratogen. Its adverse neural effects are partly mediated by disrupting fetal neurogenesis. The teratogenic process is poorly understood, and vulnerable neurogenic stages have not been identified. Identifying these is a prerequisite for therapeutic interventions to mitigate effects of teratogen exposures. Methods We used flow cytometry and qRT-PCR to screen fetal mouse-derived neurosphere cultures for ethanol-sensitive neural stem cell (NSC) subpopulations, to study NSC renewal and differentiation. The identity of vulnerable NSC populations was validated in vivo, using a maternal ethanol exposure model. Finally, the effect of ethanol exposure on the ability of vulnerable NSC subpopulations to integrate into the fetal neurogenic environment was assessed following ultrasound guided, adoptive transfer. Results Ethanol decreased NSC mRNAs for c-kit, Musashi-1and GFAP. The CD24+ NSC population, specifically the CD24+CD15+ double-positive subpopulation, was selectively decreased by ethanol. Maternal ethanol exposure also resulted in decreased fetal forebrain CD24 expression. Ethanol pre-exposed CD24+ cells exhibited increased proliferation, and deficits in cell-autonomous and cue-directed neuronal differentiation, and following orthotopic transplantation into naïve fetuses, were unable to integrate into neurogenic niches. CD24depleted cells retained neurosphere regeneration capacity, but following ethanol exposure, generated increased numbers of CD24+ cells relative to controls. Conclusions Neuronal lineage committed CD24+ cells exhibit specific vulnerability, and ethanol exposure persistently impairs this population’s cell-autonomous differentiation capacity. CD24+ cells may additionally serve as quorum sensors within neurogenic niches; their loss, leading to compensatory NSC activation, perhaps depleting renewal capacity. These data collectively advance a mechanistic hypothesis for teratogenesis leading to microencephaly.
Psychological assessments before and after treatment of early puberty in adopted children

Early puberty is frequently observed in adopted children. This randomized trial treated 30 adopted children with early puberty and short stature with either gonadotropin‐releasing hormone agonist (GnRHa) alone or in combination with growth hormone (GH) for 3 y. Before the start of treatment (T1) in the trial and at discontinuation (T2) the children and their parents underwent a psychological evaluation. At the start of treatment the children did not have increased levels of behavioural or emotional problems as assessed by the Child Behaviour Checklist (CBCL). During treatment the CBCL scores did not increase. Self‐perception of the children appeared to be normal, and after 3 y a significantly higher score for acceptance by peers was observed. At T1, an overestimation of future height was present in 80% of the children and 17% of the parents. Lower family stress was observed at T1 and T2 compared with reference values. Intelligence quotient levels decreased significantly during treatment. The findings are discussed with reference to the reported levels of behavioural and emotional problems in adopted children and the psychosocial effects of precocious puberty.
Neuroprotective Role of Vascular Endothelial Growth Factor: Signalling Mechanisms, Biological Function, and Therapeutic Potential

Vascular endothelial growth factor (VEGF or VEGF-A) and its receptors play essential roles in the formation of blood vessels during embryogenesis and in disease. Most biological effects of VEGF are mediated via two receptor tyrosine kinases, VEGFR1 and VEGFR2, but specific VEGF isoforms also bind neuropilins (NP) 1 and 2, non-tyrosine kinase receptors originally identified as receptors for semaphorins, polypeptides with essential roles in neuronal patterning. There is abundant evidence that VEGF-A has neurotrophic and neuroprotective effects on neuronal and glial cells in culture and in vivo, and can stimulate the proliferation and survival of neural stem cells. VEGFR2 and NP1 are the major VEGF receptors expressed on neuronal cells and, while the mechanisms mediating neuroprotective effects of VEGF are not fully understood, VEGF stimulates several signalling events in neuronal cell types, including activation of phospholipase C-γ, Akt and ERK. Findings in diverse models of nerve damage and disease suggest that VEGF has therapeutic potential as a neuroprotective factor. VEGF is a key mediator of the angiogenic response to cerebral and peripheral ischaemia, and promotes nerve repair following traumatic spinal injury. Recent work has revealed a role for reduced VEGF expression in the pathogenesis of amyotrophic lateral sclerosis, a rare neurodegenerative disease caused by selective loss of motor neurons. In many instances, the neuroprotective effects of VEGF appear to result from a combination of the indirect consequences of increased angiogenesis, and the direct stimulation of neuronal function. However, more work is required to determine the specific functional role of direct neuronal effects of VEGF.
Nanocrystalline ceria coatings on solid oxide fuel cell anodes: the role of organic surfactant pretreatments on coating microstructures and sulfur tolerance

Summary Treatments with organic surfactants, followed by the deposition of nanocrystalline ceria coatings from aqueous solution, were applied to anodes of solid oxide fuel cells. The cells were then operated in hydrogen/nitrogen fuel streams with H2S contents ranging from 0 to 500 ppm. Two surfactant treatments were studied: immersion in dodecanethiol, and a multi-step conversion of a siloxy-anchored alkyl bromide to a sulfonate functionality. The ceria coatings deposited after the thiol pretreatment, and on anodes with no pretreatment, were continuous and uniform, with thicknesses of 60–170 nm and 100–140 nm, respectively, and those cells exhibited better lifetime performance and sulfur tolerance compared to cells with untreated anodes and anodes with ceria coatings deposited after the sulfonate pretreatment. Possible explanations for the effects of the treatments on the structure of the coatings, and for the effects of the coatings on the performance of the cells, are discussed.
Implementing ISO/IEEE 11073: Proposal of two different strategic approaches

This paper explains the challenges encountered during the ISOfiEEE 11073 standard implementation process. The complexity of the standard and the consequent heavy requirements, which have not encouraged software engiueers to adopt the standard. The developing complexity evaluation drives us to propose two possible implementation strategies that cover almost all possible use cases and eases handling the standard by non-expert users. The first one is focused on medical devices (MD) and proposes a low-memory and low-processor usage technique. It is based on message patterns that allow simple functions to generate ISOfiEEE 11073 messages and to process them easily. In this way a framework for MDs can be obtained. Second one is focused on more powerful machines such as data loggers or gateways (aka. computer engines (CE)), which do not have the MDs' memory and processor usage constraints. For CEs a more intelligent and adaptative Plng&Play (P&P) solution is provided. It consists on a general platform that can access to any device supported by the standard. Combining both strategies will cut developing time for applications based on ISO/EEE 11073.
Construction and Efficiency of Selection Indices in Wheat (Triticum aestivum L.) under Drought Stress and Well-Irrigated Conditions

Aggregate selection helps making selection decisions for improved profitability and permits to exploit information on correlated traits to improve accuracy. In the present study, the efficiency of trait selection was assessed by the Smith-Hazel (SHI) and the Pesek-Baker (PBI) models in 35 wheat genotypes under drought stress at heading and well-irrigated conditions at the Research Farm of Shiraz University, Iran in 2011 and 2012 years. The analysis of correlated response (CR) revealed that thousand grain weight (TGW) with CR = 24.05 (in 2011) and 9.15 (in 2012) and harvest index (HI) with CR = 18.37 (in 2011) and 9.08 (in 2012) had higher indirect effects on grain yield (GY) increase under drought stress. In both years, biological yield (BY), grain number/spike (GN), TGW, and GY had the highest genetic gain ( Δ G ) in SHI model. The top ten landraces in PBI for the trials in 2011 were also placed in the top rankings for grain yield under drought stress conditions. These results and estimation of the efficiency of selection ( Δ H ) revealed that PBI ( Δ H = 19.95 and 16.5 in the first and 11.15 and 11.06 in the second year) was more efficient than SHI ( Δ H = 9.58 and 8.97 in the first and 9.74 and 8.59 in the second year) in view of identifying superior genotypes based on aggregate trait selection. Overall, repeatability estimates for grain yield (33%-57.8%) was relatively low showing that individual plant selection has low efficiency for wheat improvement whilst aggregate trait selections leads to relatively high genetic gain (1.63-2.75) for grain yield.
Patients after atrial switch operation for transposition of the great arteries can not increase stroke volume under dobutamine stress as opposed to patients with congenitally corrected transposition.

BACKGROUND Patients after atrial switch operation for transposition of the great arteries have limited exercise performance. Rigid atrial baffles may cause a relative preload reduction. Previous studies have had suboptimal control groups, which ideally should consist of patients with congenitally corrected transposition of the great arteries (ccTGA) without previous heart surgery, having a systemic right ventricle, but lacking rigid atrial baffles. Therefore the aim of this study was to test the impact of atrial baffles by comparing 12 atrial switch patients with 11 ccTGA patients. METHODS AND RESULTS Systemic right ventricular stroke volume (SV), heart rate, cardiac index, and other parameters were assessed during rest and dobutamine stress magnetic resonance imaging. The most important difference between the groups was that the atrial switch patients could not increase SV during stress, whereas ccTGA patients increased it significantly. There was no difference between groups in the rise of the cardiac index. Heart rate increased significantly more in atrial switch patients than in ccTGA patients. CONCLUSIONS The results support the hypothesis that atrial baffles restrict a rise in SV under dobutamine stress in patients after atrial switch operation for transposition of the great arteries.
The Impact of Prediction Uncertainty in Recommendations for Health-Related Behavior

In the light of the characteristics of health behavior recommendations, we discuss implications of recommendation uncertainty from a practical and ethical point of view. Considering problem complexity and data structure as well as security and autonomy aspects, we demonstrate the importance of user empowerment, fostering reflection of the recommendations and of integrating the user into the loop. In a preliminary empirical analysis, we show that presenting uncertainty to the user might help the user to reflect the recommendation and integrate him into the loop. Moreover, it might increase trust, perceived transparency, system responsibility, and overall user satisfaction. CCS CONCEPTS •Human-centered computing→ User interface design; User studies; Empirical studies in visualization;