Miracle-dz/UniFAR-FTUs huggingface dataset:
Anti)symmetric matter and superpotentials from IIB orientifolds

We study the IIB engineering of N=1 gauge theories with unitary gauge group and matter in the adjoint and (anti)symmetric representations. We show that such theories can be obtained as Z{sub 2} orientifolds of certain Calabi-Yau A{sub 2} fibrations, and discuss the explicit T-duality transformation to an orientifolded Hanany-Witten construction. The low energy dynamics is described by a geometric transition of the orientifolded background. Unlike previously studied cases, we show that the orientifold 5-''plane'' survives the transition, thus bringing a nontrivial contribution to the effective superpotential. We extract this contribution by using matrix model results and compare with geometric data. A Higgs branch of our models recovers the engineering of SO/Sp theories with adjoint matter through an O5-''plane'' T-dual to an O6-plane. We show that the superpotential agrees with that produced by engineering through an O5-''plane'' dual to an O4-plane, even though the orientifold of this second construction is replaced by fluxes after the transition.
Comparing hospital discharge records with death certificates: Can the differences be explained?

Study objective: The quality of mortality statistics is important for epidemiological research. Considerable discrepancies have been reported between death certificates and corresponding hospital discharge records. This study examines whether differences between the death certificate's underlying cause of death and the main condition from the final hospital discharge record can be explained by differences in ICD selection procedures. The authors also discuss the implications of unexplained differences for mortality data quality. Design: Using ACME, a standard software for the selection of underlying cause of death, the compatibility between the underlying cause of death and the final main condition was examined. The study also investigates whether data available in the hospital discharge record, but not reported on the death certificate, influence the selection of the underlying cause of death. Setting: Swedish death certificates for 1995 were linked to the national hospital discharge register. The resulting database comprised 69 818 people who had been hospitalised during their final year of life. Main results: The underlying cause of death and the main condition differed at Basic Tabulation List level in 54% of the deaths. One third of the differences could not be explained by ICD selection procedures. Adding hospital discharge data changed the underlying cause in 11% of deaths. For some causes of death, including medical misadventures and accidental falls, the effect was substantial. Conclusion: Most differences between underlying cause of death and final main condition can be explained by differences in ICD selection procedures. Further research is needed to investigate whether unexplained differences indicate lower data quality.
VIRTUAL MACHINE MOBILITY WITH SELF-MIGRATION

Preface This work is a continuation of the NomadBIOS project, where Asger Jensen and I designed and built what would now be termed a para-virtualized hypervisor for hosting multiple virtual machines on top of the L4 microkernel, and—to our knowledge—were the first to show the feasibility of live migration of virtual machines across a local network. Focusing on grid computing, our idea was to package each grid job in a VM, and have these VMs roam the grid in search of idle resources. NomadBIOS is described in our joint Master's thesis " Nomadic Operating Systems " [Hansen and Henriksen, 2002]. When starting my Ph.D.-studies about a year later, a group at the University of Cam-bridge had just released the first version of their own hypervisor, called Xen. Compared to the L4 microkernel on which our work was based, the Xen VMM had a number of advantages; it was simpler and faster, came with built-in drivers for up-to-date hardware, and because it was explicitly focused on hosting virtual machines, required less effort when porting or maintaining guest operating systems. Only a few weeks into my stipend, I travelled to Cambridge and started cooperating with the Xen team on bringing the live-migration features developed for NomadBIOS to Xen. While struggling to understand the design of their hypervisor, it occured to me that live VM migration would require a redesign of Xen to make it more like L4, compromising some of Xen's simplicity. Inspired by Steven Hand's " Self-paging in Nemesis " [Hand, 1999] paper, it occured to me that if a Xen guest OS could be self-paging, it also had to be possible for it to be self-migrating, able to migrate its state to another host, without outside help. After a few months of experimentation, the first prototype implementation of a self-migrating operating system was functioning, and while my research has since strayed in other—still VM related—directions, self-migration and self-checkpointing have remained at the crux of my efforts. Live VM migration in the form first implemented in NomadBIOS, is now a popular technology, because it allows system administrators to reconfigure computing resources without inconveniencing users. In contrast, the interest in self-migration has been more academic, likely because its design goals— simplicity and security—provide only little benefit in the short-term, as large-scale VM deployments are still too rare to attract any significant hacking attacks. The topic of security has increasingly attracted my attention, …
Homocysteine in patients with inflammatory bowel diseases.

BACKGROUND Hyperhomocysteinemia seems to be a common phenomenon in both patients with ulcerative colitis and Crohn's disease. Many factors including deficiencies of cobalamin, folate and pyridoxine, smoking habits, alcohol and coffee intake, some medications and age may predispose subjects to hyperhomocysteinemia. The study aimed to evaluate homocysteine levels in an inflammatory bowel disease cohort as dependent of life style and disease activity. METHODS 85 consecutive patients with inflammatory bowel disease (38 with Crohn's disease and 47 with ulcerative colitis) and 65 control subjects were included in the prospective study. The following parameters were analyzed: disease activity, duration of the disease, location of pathological changes, presence of complications, current medications, past surgical procedures, smoking history, concomitant diseases, biochemical parameters and plasma homocysteine levels. RESULTS Mild hyperhomocysteinemia was found in 16 patients with Crohn's disease (42%), 19 patients with ulcerative colitis (40%) and 19 patients in the control group (29%) (p = 0.59). There was not any significant correlation between homocysteine level and disease activity. Only folic acid supplementation and gender affected homocysteine level. Folic acid intake led to reduction of homocysteine levels in all groups of patients (11.8 micromol/l vs. 8.33 miccromol/l, p = 0.0065 in Crohn's disease patients and 10.94 micromol/l vs. 7.78 micromol/l, p = 0.0069 in ulcerative colitis patients). CONCLUSION Homocysteine level in patients with inflammatory bowel disease is mostly normal or slightly elevated. Disease activity does not have an impact on homocysteine level. Folic acid is the most important factor having an influence on homocysteine level in patients with inflammatory bowel disease.
Is heterosis in maize mediated through better water use?

SUMMARY *Heterosis increases yield potential and improves adaptation to stress in maize (Zea mays); however, the underlying mechanisms remain elusive. *A set of tropical inbred lines and their hybrids were grown in the field for 2 yr under three different water regimes. First-year plant water use was evaluated by measuring instantaneous traits (stomatal conductance (g(s)) and steady-state chlorophyll fluorescence (F(s))) in individual leaves together with time-integrative traits, which included mineral accumulation in the whole leaves of plants and oxygen isotope enrichment above source water (Delta(18)O) and carbon isotope discrimination (Delta(13)C) in the same pooled leaves and in mature kernels. Second-year water use was evaluated by measuring leaf temperature, g(s) and relative water content (RWC). *Within each growing condition, hybrids showed higher F(s), mineral accumulation, RWC, and lower leaf temperature, Delta(18)O and Delta(13)C than inbred lines. Therefore, hybrids had a better water status than inbred lines, regardless of the water conditions. Differences in grain yield across growing conditions were explained by differences in water-use traits, with hybrids and inbred lines following a common pattern. Within each growing condition, most variations in grain yield, between hybrids and inbred lines, were also explained by differences in plant water-use traits. *Heterosis in tropical maize seems to be mediated by improved water use, irrespective of the water conditions during growth.
Evaluation of the Learning Curve in Ileal Pouch–Anal Anastomosis Surgery

Summary Background Data:We define the learning curve required to attain satisfactory training in ileal pouch–anal anastomosis (IPAA) and identify possible differences in the learning curve for stapled and hand-sewn IPAA surgery. Various studies have addressed the differences in failure rate between stapled and hand-sewn IPAA, but there is no literature that evaluates the differences in attaining satisfactory training in each of these techniques. Methods:Data were collected from 1965 patients undergoing IPAA surgery by 12 surgeons in a single center between 1983 and 2001. Using ileoanal pouch failure as the primary end point, a parametric survival model was used to adjust for case mix (patient comorbidity, preoperative diagnosis, manometric findings, and prior anal pathology). A risk-adjusted cumulative sum (CUSUM) model was used for monitoring outcomes in IPAA surgery. Results:The 5-year ileal pouch survival was 95.6% (median patient follow-up of 4.2 years; range 0–19 years). Fifty percent of trainee staff demonstrated a learning curve in IPAA surgery. Having adjusted for case mix, trainee staff undertaking stapled IPAA surgery showed an improvement in the pouch failure rate following an initial training period of 23 cases versus 40 cases for senior staff. The learning curve for hand-sewn IPAA surgery was quantified only for senior staff who attained adequate results following an initial period of 31 procedures. Conclusions:The CUSUM method was a useful tool for objectively measuring performance during the learning phase of IPAA surgery. With adequate training, supervision, and monitoring, the learning curve in IPAA surgery may be reduced even further.
Speaker Identification and Verification by Combining MFCC and Phase Information

In conventional speaker recognition methods based on Mel-frequency cepstral coefficients (MFCCs), phase information has hitherto been ignored. In this paper, we propose a phase information extraction method that normalizes the change variation in the phase according to the frame position of the input speech and combines the phase information with MFCCs in text-independent speaker identification and verification methods. There is a problem with the original phase information extraction method when comparing two phase values. For example, the difference in the two values of π-\mathtildeθ1 and \mathtildeθ2=-π+\mathtildeθ1 is 2π-2\mathtildeθ1 . If \mathtildeθ1 ≈ 0, then the difference ≈ 2π, despite the two phases being very similar to one another. To address this problem, we map the phase into coordinates on a unit circle. Speaker identification and verification experiments are performed using the NTT database which consists of sentences uttered by 35 (22 male and 13 female) Japanese speakers with normal, fast and slow speaking modes during five sessions. Although the phase information-based method performs worse than the MFCC-based method, it augments the MFCC and the combination is useful for speaker recognition. The proposed modified phase information is more robust than the original phase information for all speaking modes. By integrating the modified phase information with the MFCCs, the speaker identification rate was improved to 98.8% from 97.4% (MFCC), and equal error rate for speaker verification was reduced to 0.45% from 0.72% (MFCC), respectively. We also conducted the speaker identification and verification experiments on a large-scale Japanese Newspaper Article Sentences (JNAS) database, a similar trend as NTT database was obtained.
Use of Viscosupplementation for Knee Osteoarthritis: An Update

Because of the rising numbers of patients affected by osteoarthritis (OA), management decisions on how to minimize pain and improve function in OA patients are important. Intra-articular hyaluronic acid (IAHA) knee injections have become a common treatment in the management of knee OA. In an editorial appearing in the 2007 National Knowledge Week on Osteoarthritis: National Health Service Evidence, four questions were asked about the clinical use of IAHA treatment for OA: 1) Who is the ideal candidate for HA viscosupplementation? 2) Do the mechanical and biological effects differ in importance in different stages of the disease? 3) What is the ideal dose in early- and late-stage OA? 4) Can the biological effect be delivered by means other than injection? These key issues are addressed. On the basis of results from several systemic reviews and meta-analyses, we conclude that IAHA knee injections in patients with knee OA result in modest improvements when measured by validated outcomes.
CONTROL OF WILT AND ROOT ROT INCIDENCE IN PHASEOLUS VULGARIS L. BY SOME PLANT VOLATILE COMPOUNDS

Essential oils from four plants, i.e. geranium, rosa, lemon and mint were tested for their activity in vitro and in vivo against Rhizoctonia solani and Fusarium oxysporum f. sp. phaseoli, the cause of root rot and wilt of beans. In vitro, they were found to have an inhibitory effect against the mycelial growth of R. solani and F. oxysporum f. sp. phaseoli. Complete inhibition in fungal growth was observed at a concentration of 4% of each essential oil and Topsin M at 400 ppm as well. In greenhouse the four essential oils were tested as seed coating and/or foliar spray. Results of seed coating at a concentration of 1% clearly demonstrate a good protection of emerged bean seeds against invasion of R. solani and F. oxysporum f. sp. phaseoli compared with the fungicide treatment. A similar trend was observed in a lower extent when the essential oils were applied as bean seeds coating followed by seedlings foliar spray under field conditions. Obvious yield increase as bean green pods, in all treatments, was sig- nificantly higher than in the control.
Chemoradiation related acute morbidity in carcinoma cervix and correlation with hematologic toxicity: a South Indian prospective study.

PURPOSE To assess chemoradiation related acute morbidity in women with carcinoma cervix and to find and correlation between hematologic toxicity and organ system specific damage. MATERIALS AND METHODS A prospective study was carried out between August 2012 and July 2013 enrolling 79 women with cancer cervix receiving chemo-radiotherapy. Weekly assessment of acute morbidity was done using the National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE) version 4 and the toxicities were graded. RESULTS Anemia [77 (97.5%)], vomiting [75 (94.8%)] and diarrhea [72 (91.1%)], leukopenia [11 (13.9%)], cystitis [28 (35.4%], dermatitis [19 (24.1%)] and fatigue [29 (36.71%)] were the acute toxicities noted. The toxicities were most severe in 3rd and 5th week. All women could complete radiotherapy except two due to causes unrelated to radiation morbidity; seven (8.86%) had to discontinue chemotherapy due to leukopenia and intractable diarrhea. Though there was no correlation between anemia and other toxicities, it was found that all with leukopenia had diarrhea. CONCLUSIONS Chemoradiation for cancer cervix is on the whole well tolerated. Leukopenia and severe diarrhea were the acute toxicities that compelled discontinuation of chemotherapy in two women. Though anemia had no correlation with gastrointestinal toxicity, all of those with leukopenia had diarrhea.
Population structure of Atlantic mackerel inferred from RAD‐seq‐derived SNP markers: effects of sequence clustering parameters and hierarchical SNP selection

Restriction‐site‐associated DNA sequencing (RAD‐seq) and related methods are revolutionizing the field of population genomics in nonmodel organisms as they allow generating an unprecedented number of single nucleotide polymorphisms (SNPs) even when no genomic information is available. Yet, RAD‐seq data analyses rely on assumptions on nature and number of nucleotide variants present in a single locus, the choice of which may lead to an under‐ or overestimated number of SNPs and/or to incorrectly called genotypes. Using the Atlantic mackerel (Scomber scombrus L.) and a close relative, the Atlantic chub mackerel (Scomber colias), as case study, here we explore the sensitivity of population structure inferences to two crucial aspects in RAD‐seq data analysis: the maximum number of mismatches allowed to merge reads into a locus and the relatedness of the individuals used for genotype calling and SNP selection. Our study resolves the population structure of the Atlantic mackerel, but, most importantly, provides insights into the effects of alternative RAD‐seq data analysis strategies on population structure inferences that are directly applicable to other species.
Nonexistence of Almost Moore Digraphs of Diameter Three

Almost Moore digraphs appear in the context of the degree/diameter problem as a class of extremal directed graphs, in the sense that their order is one less than the unattainable Moore bound $M(d,k)=1+d+\cdots +d^k$, where $d>1$ and $k>1$ denote the maximum out-degree and diameter, respectively. So far, the problem of their existence has only been solved when $d=2,3$ or $k=2$. In this paper, we prove that almost Moore digraphs of diameter $k=3$ do not exist for any degree $d$. The enumeration of almost Moore digraphs of degree $d$ and diameter $k=3$ turns out to be equivalent to the search of binary matrices $A$ fulfilling that $AJ=dJ$ and $I+A+A^2+A^3=J+P$, where $J$ denotes the all-one matrix and $P$ is a permutation matrix . We use spectral techniques in order to show that such equation has no $(0,1)$-matrix solutions. More precisely, we obtain the factorization in ${\Bbb Q}[x]$ of the characteristic polynomial of $A$, in terms of the cycle structure of $P$, we compute the trace of $A$ and we derive a contradiction on some algebraic multiplicities of the eigenvalues of $A$. In order to get the factorization of $\det(xI-A)$ we determine when the polynomials $F_n(x)=\Phi_n(1+x+x^2+x^3)$ are irreducible in ${\Bbb Q}[x]$, where $\Phi_n(x)$ denotes the $n$-th cyclotomic polynomial, since in such case they become 'big pieces' of $\det(xI-A)$. By using concepts and techniques from algebraic number theory, we prove that $F_n(x)$ is always irreducible in ${\Bbb Q}[x]$, unless $n=1,10$. So, by combining tools from matrix and number theory we have been able to solve a problem of graph theory.
Prevalence of thromogenic gene mutations in women with recurrent miscarriage: A retrospective study of 1,507 patients

Objective Thromogenic gene mutations has been thought to be associated with recurrent pregnancy loss in women in Turkey. The aim of this study was to investigate the prevalence of thromogenic gene mutations such as factor V Leiden (FVL, G1691T), prothrombin (G20210A), and the methylene tetrahydrofolate reductase (MTHFR, C677T) mutation in women with recurrent pregnancy loss. Methods This descriptive study was carried out in the Department of Obstetrics and Gynaecology, Harran University School of Medicine, and included a total of 1,507 women with histories of recurrent pregnancy loss between January 2010 and June 2013. The mutations were assessed by using the polymerase chain reaction. Results The homozygous mutation frequencies of FVL, prothrombin, and MTHFR were found to be 3 (0.20%), 0 and 125 (8.29%), and the heterozygous mutation frequencies were 83 (5.51%), 61 (4.05%), and 612 (40.61%), respectively. Among the 86 FVL mutation patients, 38 also had accompanying prothrombin and MTHFR mutations. Conclusion Since the homozygous forms of the FVL-prothrombin gene mutations have low incidences and MTHFR mutation is similar to a healthy population, preconceptional thromogenic gene mutations screening seems to be controversial.
Comment on "Brain IRS2 Signaling Coordinates Life Span and Nutrient Homeostasis"

Taguchi et al. (Reports, 20 July 2007, p. 369) reported that mice heterozygous for a null mutation in insulin receptor substrate–2 (Irs2) display a 17% increase in median life span. However, using the same mouse model, we find no evidence for life-span extension and suggest that the findings of Taguchi et al. were due to atypical life-span profiles in their study animals.
Auditory hallucinations and the Verbal Transformation Effect

SYNOPSIS In an attempt to replicate findings reported by Slade (1976), 12 hallucinating and 12 non-hallucinating schizophrenic subjects were compared on tests of verbal ability, personality and mental imagery variables and the Verbal Transformation Effect. No significant difference between the groups was demonstrated. When the data from both groups of schizophrenics were combined, a significant correlation was found between 2 measures of the Verbal Transformation Effect and the P-score of the Eysenck Personality Questionnaire.
Realisability and Adequacy for (Co)induction

We prove the correctness of a formalised realisability interpretation of extensions of first-order theories by inductive and coinductive definitions in an untyped $\lambda$-calculus with fixed-points. We illustrate the use of this interpretation for program extraction by some simple examples in the area of exact real number computation and hint at further non-trivial applications in computable analysis.
Deciphering the molecular basis of invasiveness in Sdhb-deficient cells

Metastatic pheochromocytomas and paragangliomas (PPGL) are malignant neuroendocrine tumors frequently associated with germline mutations in the SDHB gene. SDHB-mutated PPGL display a hypermethylator phenotype associated with hallmarks of epithelial-to-mesenchymal transition (EMT). In the present study, we report the characterization of a unique model of Sdhb knockout in mouse chromaffin cells. Sdhb deficient cells exhibit a metastatic phenotype as highlighted by increased individual cell migration (characterized by faster motility and increased persistence) as well as high invasive and adhesion abilities. This phenotype is associated with the modulation of Twist1, Twist2, Tcf3, Snai1, N-cadherin or Krt19 expression, reflecting an EMT-like reprogramming of cells. Krt19 is epigenetically silenced in Sdhb-deficient cells and re-expressed after treatment by the demethylating agent decitabine. Krt19 rescue by lentiviral transduction in Sdhb-deficient cells and Krt19 inhibition by RNA interference in wild-type cells were performed. Both studies revealed the involvement of KRT19 in the invasive phenotype by modulating collective and individual migration and cell/extra-cellular matrix adhesion properties. These findings underline the role of hypermethylation and EMT in the in vitro acquisition of metastatic properties, following SDHB loss of function.