Miracle-dz/UniFAR-FTUs huggingface dataset:
Women's Health and Equality of Men and Women

Women's health is directly related to economic and developmental level of their nations, and it is very much effected by socio-cultural factors which are related to gender discrimination. women's health needs have been oppressed and neglected in male-dominated society. For maintenance and promotion in women's health and improve of quality of life, the common idea of gender discrimination in our society and preference of having son rather than daughter from its certain from must be banished. Though the common idea of gender discrimination was a basic ideology in liberation of women, recently the aspect of difference rather than discrimination is an important matter and unique characteristics of women are strongly pointed and additionally harmonic living with men is getting to be a man idea in women's health. The social idea in gender discrimination was from christian culture in the western society and confucianism related the social norms of "Namzonyobe" (means men are honorable and women are low), "Samzongzido" (means women ought to obey certain three rules for the family), "Chilgeziak" (means seven wickedness of housewife) in this country, korea. Those ideas deprived women's ability in health management and in the decision making process for their health. Because of those cultural influences, still many pregnant women are experiencing artificial abortion when they know the fetus is a girl through ultrasound and amniocentesis.Nowadays there are many health problems of women in korea. The reasons are that Korea culture has complicatedly mixing with confucianism and western culture. Under the these cultural influences, change in value of beauty and trend of liberation in sexuality have brought out health problems, alcohol, smoking, and drug abuse in young women. In order to solve the women's health problem, first of all women have to come out of the passive manner of dependency on man. Also they should have the insight and the management and/or intervention ability of caring their health. It can be obtained through the family-society-nation wide approach as well as the approach for women themselves.
High-level approaches to confidence estimation in speech recognition

We describe some high-level approaches to estimating confidence scores for the words output by a speech recognizer. By "high-level" we mean that the proposed measures do not rely on decoder specific "side information" and so should find more general applicability than measures that have been developed for specific recognizers. Our main approach is to attempt to decouple the language modeling and acoustic modeling in the recognizer in order to generate independent information from these two sources that can then be used for estimation of confidence. We isolate these two information sources by using a phone recognizer working in parallel with the word recognizer. A set of techniques for estimating confidence measures using the phone recognizer output in conjunction with the word recognizer output is described. The most effective of these techniques is based on the construction of "metamodels," which generate alternative word hypotheses for an utterance. An alternative approach requires no other recognizers or extra information for confidence estimation and is based on the notion that a word that is semantically "distant" from the other decoded words in the utterance is likely to be incorrect. We describe a method for constructing "semantic similarities" between words and hence estimating a confidence. Results using the UK version of the Wall Street Journal are given for each technique.
Preparing Materials with a Desired Refraction Coefficient and Applications

by embedding many small particles in a given material. To implement practically this recipe, some technological problems are to be solved. These problems are formulated. Applications of the materials with a desired refraction coecient are mentioned. One of the possible applications is preparing materials with desired wave-focusing properties. These are materials which have a desired radiation pattern at a xed frequency and at a xed incident direction. The
Planulation, larval biology, and early growth of the deep-sea soft corals Gersemia fruticosa and Duva florida (Octocorallia: Alcyonacea)

Although the reproductive biology and early life-history stages of deep-sea corals are poorly understood, such data are crucial for their conservation and management. Here, we describe the timing of larval release, planula behavior, metamorphosis, settlement, and early juvenile growth of two species of deep-sea soft corals from the northwest Atlantic. Live colonies of Gersemia fruticosa maintained under flow-through laboratory conditions released 79 planulae (1.5–2.5 mm long) between April and early June 2007. Peak planulation in G. fruticosa coincided with peaks in the chlorophyll concentration and deposition rates of planktic matter. Metamorphosis and settlement occurred 3–70 d post-release. The eight primary mesenteries typically appeared within 24 h, and primary polyps grew to a height of ∼6–10 mm and a stalk diameter of ∼1 mm within 2–3 months. Planulae of Duva florida (1.5–2.5 mm long) were extracted surgically from several colonies and were successfully reared in culture. Primary polyps reached a height of ∼3–4 mm within 2–3 months. No budding of primary polyps was observed in either species over 11–13 months of monitoring, suggesting a very slow growth rate.
Resting-State Coupling between Core Regions within the Central-Executive and Salience Networks Contributes to Working Memory Performance

Previous studies investigated the distinct roles played by different cognitive regions and suggested that the patterns of connectivity of these regions are associated with working memory (WM). However, the specific causal mechanism through which the neuronal circuits that involve these brain regions contribute to WM is still unclear. Here, in a large sample of healthy young adults, we first identified the core WM regions by linking WM accuracy to resting-state functional connectivity with the bilateral dorsolateral prefrontal cortex (dLPFC; a principal region in the central-executive network, CEN). Then a spectral dynamic causal modeling (spDCM) analysis was performed to quantify the effective connectivity between these regions. Finally, the effective connectivity was correlated with WM accuracy to characterize the relationship between these connections and WM performance. We found that the functional connections between the bilateral dLPFC and the dorsal anterior cingulate cortex (dACC) and between the right dLPFC and the left orbital fronto-insular cortex (FIC) were correlated with WM accuracy. Furthermore, the effective connectivity from the dACC to the bilateral dLPFC and from the right dLPFC to the left FIC could predict individual differences in WM. Because the dACC and FIC are core regions of the salience network (SN), we inferred that the inter- and causal-connectivity between core regions within the CEN and SN is functionally relevant for WM performance. In summary, the current study identified the dLPFC-related resting-state effective connectivity underlying WM and suggests that individual differences in cognitive ability could be characterized by resting-state effective connectivity.
Technology and Labor Regulations

Many low skilled jobs have been substituted away for machines in Europe, or eliminated, much more so than in the US, while technological progress at the “top”, i.e. at the high-tech sector, is faster in the US than in Europe. This paper suggests that the main difference between Europe and the US in this respect is their different labor market policies. European countries reduce wage flexibility and inequality through a host of labor market regulations, like binding minimum wage laws, permanent unemployment subsidies, firing costs, etc. Such policies create incentives to develop and adopt labor saving capital intensive technologies at the low end of the skill distribution. At the same time technical change in the US is more skill biased than in Europe, since American skilled wages are higher. In the last few years some partial labor market reforms in Europe may have started to slow down or even reverse this trend.
The Realization of LED Display System Based on the Embedded

In this paper, a design of LED display control system based on ARM and FPGA is proposed, according to module structure characteristics of the RGB three colors LED display and the dynamic scanning display of the LED display which is achieved by FPGA technology, this system uses ARM chip S3C2240 as the control core. with the help of the programmable logic device auxiliary, it completed the data storage and update, display refresh, animation, cycle display; and achieved communication through Ethernet and PC; the system supports text’s and picture’s display of full color LED screen which is separated in 256 grayscale, and a remote data transmission. DOI: http://dx.doi. org/10.11591/telkomnika.v11i5. 2496 Full Text: PDF
Synthetic Farnesoid X Receptor Agonists Induce High-Density Lipoprotein-Mediated Transhepatic Cholesterol Efflux in Mice and Monkeys and Prevent Atherosclerosis in Cholesteryl Ester Transfer Protein Transgenic Low-Density Lipoprotein Receptor (−/−) Mice

Farnesoid X receptor (FXR), a bile acid-activated nuclear hormone receptor, plays an important role in the regulation of cholesterol and more specifically high-density lipoprotein (HDL) homeostasis. Activation of FXR is reported to lead to both pro- and anti-atherosclerotic effects. In the present study we analyzed the impact of different FXR agonists on cholesterol homeostasis, plasma lipoprotein profiles, and transhepatic cholesterol efflux in C57BL/6J mice and cynomolgus monkeys and atherosclerosis development in cholesteryl ester transfer protein transgenic (CETPtg) low-density lipoprotein receptor (LDLR) (−/−) mice. In C57BL/6J mice on a high-fat diet the synthetic FXR agonists isopropyl 3-(3,4-difluorobenzoyl)-1,1-dimethyl-1,2,3,6-tetrahydroazepino[4,5-b]indole-5-carboxylate (FXR-450) and 4-[2-[2-chloro-4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-4-isoxazolyl]methoxy]phenyl]cyclopropyl]benzoic acid (PX20606) demonstrated potent plasma cholesterol-lowering activity that affected all lipoprotein species, whereas 3-[2-[2-chloro-4-[[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methoxy]phenyl]ethenyl]benzoic acid (GW4064) and 6-ethyl chenodeoxycholic acid (6-ECDCA) showed only limited effects. In FXR wild-type mice, but not FXR(−/−) mice, the more efficacious FXR agonists increased fecal cholesterol excretion and reduced intestinal cholesterol (re)uptake. In CETPtg-LDLR(−/−) mice PX20606 potently lowered total cholesterol and, despite the observed HDL cholesterol (HDLc) reduction, caused a highly significant decrease in atherosclerotic plaque size. In normolipidemic cynomolgus monkeys PX20606 and 6-ECDCA both reduced total cholesterol, and PX20606 specifically lowered HDL2c but not HDL3c or apolipoprotein A1. That pharmacological FXR activation specifically affects this cholesterol-rich HDL2 subclass is a new and highly interesting finding and sheds new light on FXR-dependent HDLc lowering, which has been perceived as a major limitation for the clinical development of FXR agonists.
A semantic clustering routing protocol for wireless sensor networks

The paper presents a new clustering scheme for wireless sensor networks based on semantic properties. Unlike current clustering schemes where signal strength and neighbouring are the most used criteria in the cluster formation, in this work, semantic properties are also taken in consideration in the process of cluster formation. Nodes inside a same cluster are organized like a hyper tree where the cluster-head is the root. This hyper tree organization allows a layered data aggregation, avoids the clusterhead overload and energy dissipation, and makes the network more robust against links and nodes failures. We evaluate this work by simulations and show that our approach is more efficient and more energy conservative than other clustering schemes.
The Cosmic Coalescence Rates for Double Neutron Star Binaries

We report on the newly increased event rates due to the recent discovery of the highly relativistic binary pulsar J0737-3039. Using a rigorous statistical method, we present the calculations reported by Burgay et al., which produce a coalescence rate for Galactic double neutron star (DNS) systems that is higher by a factor of 6-7 compared to estimates made prior to the new discovery. Our method takes into account known pulsar survey selection effects and biases due to small-number statistics. This rate increase has dramatic implications for gravitational wave detectors. For the initial Laser Interferometer Gravitational-Wave Observatory (LIGO) detectors, the most probable detection rates for DNS in-spirals are one event per 5-250 yr; at 95% confidence, we obtain rates up to one per 1.5 yr. For the advanced LIGO detectors, the most probable rates are 20-1000 events per year. These predictions, for the first time, bring the expectations for DNS detections by the initial LIGO detectors to the astrophysically relevant regime. We also use our models to predict that the large-scale Parkes Multibeam pulsar survey with acceleration searches could detect an average of three to four binary pulsars similar to those known at present.
Stress relief

The use of 3D printing has rapidly expanded in the past couple of years. It is now possible to produce 3D-printed objects with exceptionally high fidelity and precision. However, although the quality of 3D printing has improved, both the time to print and the material costs have remained high. Moreover, there is no guarantee that a printed model is structurally sound. The printed product often does not survive cleaning, transportation, or handling, or it may even collapse under its own weight. We present a system that addresses this issue by providing automatic detection and correction of the problematic cases. The structural problems are detected by combining a lightweight structural analysis solver with 3D medial axis approximations. After areas with high structural stress are found, the model is corrected by combining three approaches: hollowing, thickening, and strut insertion. Both detection and correction steps are repeated until the problems have been eliminated. Our process is designed to create a model that is visually similar to the original model but possessing greater structural integrity.
Using doxorubicin and siRNA-loaded heptapeptide-conjugated nanoparticles to enhance chemosensitization in epidermal growth factor receptor high-expressed breast cancer cells

Abstract The aim of this study was to develop the heptapeptide-conjugated active targeting nanoparticles for delivery of doxorubicin and siRNA to epidermal growth factor receptor (EGFR) high-expressed breast cancer cells. The active targeting nanoparticles were prepared by using a synthesized poly(D,L-lactide-co-glycolide)-poly(ethylene glycol) (PLGA-PEG) copolymer conjugated with a heptapeptide. The particle size of peptide-conjugated nanoparticles was less than 200 nm with narrow size distribution and the surface charge was negative. The uptake of peptide-conjugated nanoparticles was more efficient in EGFR high-expressed MDA-MB-468 cells than in EGFR low-expressed HepG2 cells by 3.9 folds due to peptide specific binding to EGF receptor followed by EGF receptor-mediated endocytosis. The nanoparticles were used to deliver doxorubicin and siRNA, and their in vitro release was faster in pH 4.0 (500 U lipase) than in pH 7.4. The IC50 of doxorubicin-loaded peptide-conjugated nanoparticles was lower than that of peptide-free nanoparticles by 2.3 folds in MDA-MB-468 cells. Similarly, the cellular growth inhibition of siRNA/DOTAP-loaded peptide-conjugated nanoparticles was 2.1 folds higher than that of peptide-free nanoparticles. In conclusion, the heptapeptide-conjugated PLGA-PEG nanoparticles provided active targeting potential to EGFR high-expressed MDA-MB-468 breast cancer cells, and a synergistic cytotoxicity effect was achieved by co-delivery of doxorubicin and siRNA/DOTAP-loaded peptide-conjugated nanoparticles.
2. DeShazer D, Waag DM, Fritz DL, Woods DE: Identification of a Burkholderia mallei polysaccharide gene cluster by subtractive hybridization

Table S1. Bacterial strains used to examine the host range of bacteriophage E202. Bacterial strain Source or reference Plaque formation Burkholderia mallei NCTC 120 NCTC NCTC 10248 “ + NCTC 10229 “ + NCTC 10260 “ + NCTC 10247 “ + NCTC 3708 “ + NCTC 3709 “ + ATCC 23344 ATCC + ATCC 10399 “ + ATCC 15310 “ + DB110795 [1] DD3008 [2] + Burkholderia pseudomallei 316c [3] NCTC 4845 NCTC + 1026b [4] WRAIR 1188, USAMRU Malaysia 32, Pasteur 52237, STW 176, STW 152, STW 1023, STW 35-1 [5] -
Enhanced satellite cell proliferation with resistance training in elderly men and women

In addition to the well‐documented loss of muscle mass and strength associated with aging, there is evidence for the attenuating effects of aging on the number of satellite cells in human skeletal muscle. The aim of this study was to investigate the response of satellite cells in elderly men and women to 12 weeks of resistance training. Biopsies were collected from the m. vastus lateralis of 13 healthy elderly men and 16 healthy elderly women (mean age 76±SD 3 years) before and after the training period. Satellite cells were visualized by immunohistochemical staining of muscle cross‐sections with a monoclonal antibody against neural cell adhesion molecule (NCAM) and counterstaining with Mayer's hematoxylin. Compared with the pre‐training values, there was a significant increase (P<0.05) in the number of NCAM‐positively stained cells per fiber post‐training in males (from 0.11±0.03 to 0.15±0.06; mean±SD) and females (from 0.11±0.04 to 0.13±0.05). These results suggest that 12 weeks of resistance training is effective in enhancing the satellite cell pool in skeletal muscle in the elderly.
Role of anterior temporal cortex in auditory sentence comprehension: an fMRI study

Recent neuropsychological and functional imaging evidence has suggested a role for anterior temporal cortex in sentence-level comprehension. We explored this hypothesis using event-related fMRI. Subjects were scanned while they listened to either a sequence of environmental sounds describing an event or a corresponding sentence matched as closely as possible in meaning. Both types of stimuli required subjects to integrate auditory information over time to derive a similar meaning, but differ in the processing mechanisms leading to the integration of that information, with speech input requiring syntactic mechanisms and environmental sounds utilizing non-linguistic mechanisms. Consistent with recent claims, sentences produced greater activation than environmental sounds in anterior superior temporal lobe bilaterally. A similar speech > sound activation pattern was noted also in posterior superior temporal regions in the left. Envirornmental sounds produced greater activation than sentences in right inferior frontal gyrus. The results provide support for the view that anterior temporal cortex plays an important role in sentence-level comprehension.
Edge-end Pixel Extraction for Edge-based Image Segmentation

— Extraction of edge-end-pixels is an important step for the edge linking process to achieve edge-based image segmentation. This paper presents an algorithm to extract edge-end pixels together with their directional sensitivities as an augmentation to the currently available mathematical models. The algorithm is implemented in the Java environment because of its inherent compatibility with web interfaces since its main use is envisaged to be for remote image analysis on a virtual instrumentation platform.
Creb-Binding Protein (Cbp/P300) and RNA Polymerase II Colocalize in Transcriptionally Active Domains in the Nucleus

The spatial organization of transcription- associated proteins is an important control mechanism of eukaryotic gene expression. Here we analyzed the nuclear distribution of the transcriptional coactivators CREB-binding protein (CBP)/p300 in situ by confocal laser scanning microscopy, and in vivo complex formation by coimmunoprecipitation. A subpopulation of CBP and p300 is targeted to active sites of transcription and partially colocalizes with hyper- and hypophosphorylated RNA polymerase II (pol II) in discrete regions of variable size throughout the nucleus. However, the coactivators were found in tight association with hypophosphorylated, but not hyperphosphorylated pol II. Transcriptional inhibition induced a relocation of CBP/p300 and pol II into speckles. Moreover, double and triple immunofluorescence analyses revealed the presence of CBP, p300, and pol II in a subset of promyelocytic leukemia (PML) bodies. Our results provide evidence for a dynamic spacial link between coactivators of transcription and the basal transcription machinery in discrete nuclear domains dependent upon the transcriptional activity of the cell. The identification of pol II in CBP/PML-containing nuclear bodies supports the idea that transcription takes place at PML bodies.
CDC25B associates with a centrin 2-containing complex and is involved in maintaining centrosome integrity

Background information. CDC25 (cell division cycle 25) phosphatases function as activators of CDK (cyclin‐dependent kinase)–cyclin complexes to regulate progression through the CDC. We have recently identified a pool of CDC25B at the centrosome of interphase cells that plays a role in regulating centrosome numbers.
Rising from a chair A simple screening test for physical function in predialysis patients

Objectives. Patients with chronic end-stage renal diseases have decreased physical fitness. This physical deconditioning is relative but the consequences in daily life are related to functional thresholds. The main purpose of this study was to gather information about physical performance, physical fitness and activity in predialysis patients. A second aim was to investigate the possibility of identifying patients at risk of physical deconditioning using clinical tests. Material and methods. Fifty-five predialysis patients with a glomerular filtration rate (GFR) of ≤20 ml/min/1.73 m2 were investigated. They filled out questionnaires about their physical activity. Muscle performance was measured by using an electronic force transducer for grip strength and knee extension. Clinical tests, such as ‘Timed up and go’, walking, standing heel-rise and ‘Climbing up a 45-cm high step’, were performed. Results. There were no associations between GFR and the assessments of the above-mentioned tests. However, odds ratios calculated for ‘Rising from a 45-cm chair without using the arms’ and GFR and diabetes showed that, for every 1 ml/min/1.73 m2 drop in GFR, the odds were 1.5 times higher that the patient would not be able to rise from a chair and, when the diagnosis was diabetes, the odds ranged from 1.7 to 21 times higher. Conclusions. Patients, especially diabetics, with chronic renal failure with a GFR of ≤20 ml/min/1.73 m2 have decreased physical fitness. ‘Rising from a 45-cm chair without using the arms’ is an uncomplicated test to use in the clinical setting for identifying patients who need help with muscle training and functional exercise in order to improve their everyday functioning.