Miracle-dz/UniFAR-FTUs huggingface dataset:
Preliminary Design of a 2D Supersonic Inlet to Maximize Total Pressure Recovery

*† This paper provides a method of preliminary design for a two-dimensional, mixed compression, two-ramp supersonic inlet to maximize total pressure recovery and match the mass flow demand of the engine. For an on-design condition, the total pressure recovery is maximized according to the optimization criterion, and the dimensions of the inlet in terms of ratios to the engine face diameter are calculated. The optimization criterion is defined such that in a system of (n-1) oblique shocks and one normal shock in two dimensions, the maximum shock pressure recovery is obtained when the shocks are of equal strength. This paper also provides a method to estimate the total pressure recovery for an off-design condition for the specified inlet configuration. For an off-design condition, conservative estimation of the total pressure recovery is given so that performance of the engine at the off-design condition can be estimated. To match the mass flow demand of the engine, the second ramp angle is adjusted and the open/close schedule of a bypass door is determined. The effects of boundary layer are not considered for the supersonic part of the inlet, however friction and expansion losses are considered for the subsonic diffuser. Nomenclature α = Angle of attack j β = The installation angle of the j th ramp γ = The ratio of specific heats j δ = The flow deflection angle of the j th shock (j th ramp half angle) d θ = The half expansion angle of the subsonic diffuser j θ = The shock wave angle of the j th shock * A = The cross section area of flow tube at throat where the flow is sonic j A = The cross section area of flow at j th station point 54 AR = The ratio of inlet cross section areas at station points 5 and 4 5 d = The engine diameter at station point 5 (engine face) 6 d = The engine diameter at station point 6 (fan face) H = Flight altitude c h , 0 h = The captured freestream flow tube height i h = The height of inlet at the entry, measured perpendicular to the flight direction j h = The height of j
Polarized sorting of beta-amyloid precursor protein and its proteolytic products in MDCK cells is regulated by two independent signals

Progressive cerebral deposition of the amyloid (A beta) beta-protein is an early and invariant feature of Alzheimer's disease. A beta is derived by proteolysis from the membrane-spanning beta-amyloid precursor protein (beta APP). beta APP is processed into various secreted products, including soluble beta APP (APPs), the 4-kD A beta peptide, and a related 3-kD peptide (p3). We analyzed the mechanisms regulating the polarized basolateral sorting of beta APP and its proteolytic derivatives in MDCK cells. Deletion of the last 32 amino acids (residues 664-695) of the beta APP cytoplasmic tail had no influence on either the constitutive approximately 90% level of basolateral sorting of surface beta APP, or the strong basolateral secretion of APPs, A beta, and p3. However, deleting the last 42 amino acids (residues 654-695) or changing tyrosine 653 to alanine altered the distribution of cell surface beta APP so that approximately 40-50% of the molecules were inserted apically. In parallel, A beta was now secreted from both surfaces. Surprisingly, this change in surface beta APP had no influence on the basolateral secretion of APPs and p3. This result suggests that most beta APP molecules which give rise to APPs in MDCK cells are cleaved intracellularly before reaching the surface. Consistent with this conclusion, we readily detected intracellular APPs in carbonate extracts of isolated membrane vesicles. Moreover, ammonium chloride treatment resulted in the equal secretion of APPs into both compartments, as occurs with other non-membranous, basolaterally secreted proteins, but it did not influence the polarity of cell surface beta APP. These results demonstrate that in epithelial cells two independent mechanisms mediate the polarized trafficking of beta APP holoprotein and its major secreted derivative (APPs) and that A beta peptides are derived in part from beta APP holoprotein targeted to the cell surface by a signal that includes tyrosine 653.
Hamming embedding similarity-based image classification

In this paper, we propose a novel image classification framework based on patch matching. More precisely, we adapt the Hamming Embedding technique, first introduced for image search to improve the bag-of-words representation. This matching technique allows the fast comparison of descriptors based on their binary signatures, which refines the matching rule based on visual words and thereby limits the quantization error. Then, in order to allow the use of efficient and suitable linear kernel-based SVM classification, we propose a mapping method to cast the scores output by the Hamming Embedding matching technique into a proper similarity space. Comparative experiments of our proposed approach and other existing encoding methods on two challenging datasets PASCAL VOC 2007 and Caltech-256, report the interest of the proposed scheme, which outperforms all methods based on patch matching and even provide competitive results compared with the state-of-the-art coding techniques.
Co-Evolution of Organizational Network and Individual Behavior: an Agent-Based Model of Interpersonal Knowledge Transfer

This study focuses on the co-evolution of informal organizational structures and individual knowledge transfer behavior within organizations. Our research methodology distinguishes us from other similar studies. We use agent-based modeling and dynamic social network analysis, which allow for a dynamic perspective and a bottom-up approach. We study the emergent network structures and behavioral patterns, as well as their micro-level foundations. We also examine the exogenous factors influencing the emergent process. We ran simulation experiments on our model and found some interesting findings. For example, it is observed that knowledgeable individuals are not well connected in the network, and our model suggests that being fully involved in knowledge transfer might undermine individuals' knowledge advantage over time. Another observation is that when there is high knowledge diversity in the system, informal organizational structure tends to form a network of good reachability; that is, any two individuals are connected via a few intermediates.
Self-calibration for a 3D laser

In this paper we describe a method for the automatic self-calibration of a 3D laser sensor. We wish to acquire crisp point clouds and so we adopt a measure of crispness to capture point cloud quality. We then pose the calibration problem as the task of maximizing point cloud quality. Concretely, we use Rényi Quadratic Entropy to measure the degree of organization of a point cloud. By expressing this quantity as a function of key unknown system parameters, we are able to deduce a full calibration of the sensor via an online optimization. Beyond details on the sensor design itself, we fully describe the end-to-end intrinsic parameter calibration process and the estimation of the clock skews between the constituent microprocessors. We analyse performance using real and simulated data and demonstrate robust performance over 30 test sites.
Running: the risk of coronary events : Prevalence and prognostic relevance of coronary atherosclerosis in marathon runners.

AIMS To quantify the prevalence of coronary artery calcification (CAC) in relation to cardiovascular risk factors in marathon runners, and to study its role for myocardial damage and coronary events. METHODS AND RESULTS In 108 apparently healthy male marathon runners aged >or=50 years, with >or=5 marathon competitions during the previous three years, the running history, Framingham risk score (FRS), CAC, and presence of myocardial late gadolinium enhancement (LGE) were measured. Control groups were matched by age (8:1) and FRS (2:1) from the Heinz Nixdorf Recall Study. The FRS in marathon runners was lower than in age-matched controls (7 vs. 11%, P < 0.0001). However, the CAC distribution was similar in marathon runners and age-matched controls (median CAC: 36 vs. 38, P = 0.36) and higher in marathon runners than in FRS-matched controls (median CAC: 36 vs. 12, P = 0.02). CAC percentile values and number of marathons independently predicted the presence of LGE (prevalence = 12%) (P = 0.02 for both). During follow-up after 21.3 +/- 2.8 months, four runners with CAC >or= 100 experienced coronary events. Event-free survival was inversely related to CAC burden (P = 0.018). CONCLUSION Conventional cardiovascular risk stratification underestimates the CAC burden in presumably healthy marathon runners. As CAC burden and frequent marathon running seem to correlate with subclinical myocardial damage, an increased awareness of a potentially higher than anticipated coronary risk is warranted.
Spectral Classification of Quasars in the Sloan Digital Sky Survey: Eigenspectra, Redshift, and Luminosity Effects

We study 16,707 quasar spectra from the Sloan Digital Sky Survey (SDSS) (an early version of the First Data Release; DR1) using the Karhunen-Loève transform (or principal components analysis). The redshifts of these quasars range from 0.08 to 5.41, the i-band absolute magnitudes from -30 to -22, and the resulting rest-frame wavelengths from 900 to 8000 Å. The quasar eigenspectra of the full catalog reveal the following: first order—the mean spectrum; second order—a host-galaxy component; third order—the UV-optical continuum slope; fourth order—the correlations of Balmer emission lines. These four eigenspectra account for 82% of the total sample variance. Broad absorption features are found not to be confined in one particular order but to span a number of higher orders. We find that the spectral classification of quasars is redshift and luminosity dependent; as such there does not exist a compact set (i.e., less than ≈10 modes) of eigenspectra (covering 900–8000 Å) that can describe most variations (i.e., greater than ≈95%) of the entire catalog. We therefore construct several sets of eigenspectra in different redshift and luminosity bins. From these eigenspectra we find that quasar spectra can be classified (by the first two eigenspectra) into a sequence that is defined by a simple progression in the steepness of the slope of the continuum. We also find a dependence on redshift and luminosity in the eigencoefficients. The dominant redshift effect is a result of the evolution of the blended Fe II emission (optical) and the Balmer continuum (the "small bump," λrest ≈ 2000–4000 Å). A luminosity dependence is also present in the eigencoefficients and is related to the Baldwin effect—the decrease of the equivalent width of an emission line with luminosity, which is detected in Lyα, Si IV+O IV], C IV, He II, C III] and Mg II, while the effect in N V seems to be redshift dependent. If we restrict ourselves to the rest-wavelength regions 1150–2000 Å and 4000–5500 Å, the eigenspectra constructed from the wavelength-selected SDSS spectra are found to agree with the principal components by Francis et al. and the well-known "Eigenvector-1" of Boroson & Green, respectively. ASCII formatted tables of the eigenspectra are available.
Perceptions of Company Performance: A study of impression management

The purpose of this research is to investigate two particular forms of impression management commonly found in corporate annual reports, the distortion of narratives and graph manipulation. Little is known about the potential effects these manipulations have on decisions made by annual report users. A laboratory experiment was performed in which participants were provided with a pack of information for two fictional companies and required to make an investment decision. No significant difference was found between the investment decisions of the participants, confirming previous findings that impression management does not affect corporate annual report users’ perceptions of company performance.
Autonomous ground vehicle path tracking

Autonomous ground vehicle navigation requires the integration of many technologies such as path planning, position and orientation sensing, vehicle control, and obstacle avoidance. The work presented here focuses on the control of a nonholonomic ground vehicle as it tracks a given path. A new path tracking technique called “vector pursuit” is presented. This new technique is based on the theory of screws, which was developed by Sir Robert Ball in 1900. It generates a desired vehicle turning radius based on the vehicle's current position and orientation relative to the position of a point ahead on the planned path and the desired orientation along the path at that point. The vector pursuit algorithm is compared to other geometrical approaches, and it is shown to be more robust, resulting in more accurate path tracking. © 2004 Wiley Periodicals, Inc.
Clinical Implications of Sulcal Enhancement on Postcontrast Fluid Attenuated Inversion Recovery Images in Patients with Acute Stroke Symptoms

Objective Hyperintense acute reperfusion marker (HARM) without diffusion abnormalities is occasionally found in patients with an acute stroke. This study was to determine the prevalence and clinical implications of HARM without diffusion abnormalities. Materials and Methods There was a retrospective review of magnetic resonance images 578 patients with acute strokes and identified those who did not have acute infarction lesions, as mapped by diffusion-weighted imaging (DWI). These patients were classified into an imaging-negative stroke and HARM without diffusion abnormalities groups, based on the DWI findings and postcontrast fluid attenuated inversion recovery images. The National Institutes of Health Stroke Scale (NIHSS) scores at admission, 1 day, and 7 days after the event, as well as clinical data and risk factors, were compared between the imaging-negative stroke and HARM without diffusion abnormalities groups. Results Seventy-seven acute stroke patients without any DWI abnormalities were found. There were 63 patients with an imaging-negative stroke (accounting for 10.9% of 578) and 13 patients with HARM without diffusion abnormalities (accounting for 2.4% of 578). The NIHSS scores at admission were higher in HARM without diffusion abnormalities group than in the imaging-negative stroke group (median, 4.5 vs. 1.0; p < 0.001), but the scores at 7 days after the event were not significantly different between the two groups (median, 0 vs. 0; p = 1). The patients with HARM without diffusion abnormalities were significantly older, compared with patients with an imaging-negative stroke (mean, 73.1 years vs. 55.9 years; p < 0.001). Conclusion Patients with HARM without diffusion abnormalities are older and have similarly favorable short-term neurological outcomes, compared with the patients with imaging-negative stroke.
Increased Insomnia Symptoms Predict the Onset of Back Pain among Employed Adults

Background Back pain is among the most prevalent pain disorders causing chronic disability among adults, and insomnia is a common co-morbidity. However, whether insomnia precedes back pain or vice versa remains unclear. The current study tested the temporal association between insomnia and back pain. Methods A longitudinal design was used to investigate whether changes in insomnia over time predict the onset of back pain and vice versa. The study was conducted on a cohort of active healthy working adults (N = 2,131, 34% women) at three time points (T1, T2, and T3) over a period of 3.7 years (range = 2.2–5.12) years. Logistic regression analysis was used to test whether increased insomnia symptoms from T1 to T2 predicted the onset of new back pain. Ordinary least squares regression was used to test whether the existence of back pain at T2 predicted an increase in insomnia from T2 to T3. Results The results indicated that after controlling for socioeconomic variables, self-reported health, lifestyle behaviors, and anthropometrics, a T1–T2 increase in insomnia symptoms was associated with a 1.40-fold increased risk of back pain at T3 (OR = 1.40; 95% CI = 1.10–1.71). No support was found for reverse causation; i.e., that back pain predicts subsequent increase in insomnia. Conclusions Insomnia appears to be a risk factor in the development of back pain in healthy individuals. However, no evidence of reverse causation was found.
Expression profile of genes in non-small cell lung carcinomas from long-term surviving patients.

PURPOSE Non-small cell lung cancer (NSCLC) is usually associated with a poor prognosis. Some patients survive their disease, and the underlying molecular mechanisms are still poorly understood. The purpose of this investigation was to evaluate expression profiles of proteins determining the survival of NSCLC patients for 5 years. EXPERIMENTAL DESIGN The expression of 21 gene products was evaluated immunohistochemically in paraffinembedded primary NSCLCs from 216 patients. The data were correlated with the survival times of the patients (survival of more or less than 5 years) by means of chi(2) test and hierarchical cluster analysis. RESULTS The relationships of patients' survival and 21 parameters were determined including oncogene and tumor suppressor products and proliferative, apoptotic, and angiogenic factors. FOS, P53, RAS, ERBB1, JUN, PCNA, cyclin A, FAS/CD95, and HIF-1beta revealed a correlation to survival. In a second step, these nine parameters were further analyzed by hierarchical cluster analyses of all patients, of stage III patients, and of patients with squamous cell lung carcinomas. We identified clusters with significantly more long-term survivors. The expression of FOS, JUN, ERBB1, and cyclin A or PCNA were decreased in carcinomas of patients with long-term survival. CONCLUSIONS The expression profile of these factors predicts a significantly better long-term outcome of NSCLC patients. This may have implications for the development of individualized therapy options in the future.
Characterization of p53 and p21 functional interactions in glioma cells en route to apoptosis.

BACKGROUND Alterations of the p53 (also called TP53) gene are one of the most common abnormalities in gliomas. We have previously reported that restoration of wild-type p53 protein function in glioma cells results in programmed cell death (apoptosis). Since p53 functions are mediated by genes that directly control the tumor suppressor effect of the p53 protein, understanding the relationship between p53 and p53-related genes in glioma cells will aid in the design of more rational treatment strategies for brain tumors. PURPOSE We conducted this study to examine the timing of the p53-mediated events preceding apoptosis. More specifically, we undertook this work to characterize the genetic and cell cycle-related factors that may increase the resistance of glioma cells to p53-induced apoptosis. METHODS Two human glioma cell lines (U-251 MG and U-373 MG) that express mutant p53 protein and two (U-87 MG and EFC-2) that express wild-type p53 protein were used. Replication-deficient adenovirus was utilized as an expression vector to transfer exogenous p53 and p21 complementary DNAs into the glioma cells; control cells were infected with the viral expression vector alone. To monitor gene transfer and the expression of exogenous genes (as well as the expression of endogenous genes), we used western blot analyses and immunohistochemistry analyses. Flow cytometry studies of cellular DNA content were performed to determine the cell cycle phenotype of the glioma cells before and after treatment. RESULTS p53-mediated apoptosis was preceded by elevation in the levels of the p21 (cell cycle-related) and Bax (apoptosis-related) proteins. In addition, cell cycle analyses showed that glioma cells were arrested in the G2 phase before undergoing cell death. Transfer of p21 induced a G2 block but did not induce apoptosis. Moreover, coexpression of p21 and p53 prevented glioma cells from undergoing apoptosis. Expression of exogenous p53 in wild-type p53 cells did not induce elevation of Bax levels, arrest in G2 phase, or apoptosis. CONCLUSIONS AND IMPLICATIONS Our data confirmed the ability of wild-type p53 to induce apoptosis in p53 mutant glioma cells. In addition, our results document that p21 plays a role in protecting cells from p53-mediated programmed cell death and suggest that p53-mediated apoptosis and p21 induction may represent, at least in certain cases, opposite signals. Finally, our data suggest that over expression of p21 in gliomas may be related to resistance to treatments that induce apoptosis.
Sequence determinants of improved CRISPR sgRNA design

The CRISPR/Cas9 system has revolutionized mammalian somatic cell genetics. Genome-wide functional screens using CRISPR/Cas9-mediated knockout or dCas9 fusion-mediated inhibition/activation (CRISPRi/a) are powerful techniques for discovering phenotype-associated gene function. We systematically assessed the DNA sequence features that contribute to single guide RNA (sgRNA) efficiency in CRISPR-based screens. Leveraging the information from multiple designs, we derived a new sequence model for predicting sgRNA efficiency in CRISPR/Cas9 knockout experiments. Our model confirmed known features and suggested new features including a preference for cytosine at the cleavage site. The model was experimentally validated for sgRNA-mediated mutation rate and protein knockout efficiency. Tested on independent data sets, the model achieved significant results in both positive and negative selection conditions and outperformed existing models. We also found that the sequence preference for CRISPRi/a is substantially different from that for CRISPR/Cas9 knockout and propose a new model for predicting sgRNA efficiency in CRISPRi/a experiments. These results facilitate the genome-wide design of improved sgRNA for both knockout and CRISPRi/a studies.
Fusion of audio and video modalities for detection of acoustic events

Detection of acoustic events (AED) that take place in a meeting-room environment becomes a difficult task when signals show a large proportion of temporal overlap of sounds, like in seminar-type data, where the acoustic events often occur simultaneously with speech. Whenever the event that produces the sound is related to a given position or movement, video signals may be a useful additional source of information for AED. In this work, we aim at improving the AED accuracy by using two complementary audio-based AED systems, built with SVM and HMM classifiers, and also a video-based AED system, which employs the output of a 3D video tracking algorithm to improve detection of steps. Fuzzy integral is used to fuse the outputs of the three classification systems in two stages. Experimental results using the CLEAR'07 evaluation data show that the detection rate increases by fusing the two audio information sources, and it is further improved by including video information.
Relaying for pair-wise information exchange

In the two-way relay channel, two sources exchange information with help from a relay. We study a more general relay network with additional pairs of sources that perform pair-wise information exchange. We obtain achievable rate regions for amplify-and-forward and decode-and-forward (DF) relaying schemes based on both Gaussian codes and lattice codes, assuming a two-phase protocol. The lattice-code-based DF scheme is near optimal, in that the achievable rate region lies within one bit of the capacity region for two pairs of information exchange.