Miracle-dz/UniFAR-FTUs huggingface dataset:
Superficial cells are self‐renewing chondrocyte progenitors, which form the articular cartilage in juvenile mice

Articular cartilage has little regenerative capacity. Recently, genetic lineage tracing experiments have revealed chondrocyte progenitors at the articular surface. We further characterized these progenitors by using in vivo genetic approaches. Histone H2B–green fluorescent protein retention revealed that superficial cells divide more slowly than underlying articular chondrocytes. Clonal genetic tracing combined with immunohistochemistry revealed that superficial cells renew their number by symmetric division, express mesenchymal stem cell markers, and generate chondrocytes via both asymmetric and symmetric differentiation. Quantitative analysis of cellular kinetics, in combination with phosphotungstic acid–enhanced micro–computed tomography, showed that superficial cells generate chondrocytes and contribute to the growth and reshaping of articular cartilage. Furthermore, we found that cartilage renewal occurs as the progeny of superficial cells fully replace fetal chondrocytes during early postnatal life. Thus, superficial cells are self‐renewing progenitors that are capable of maintaining their own population and fulfilling criteria of unipotent adult stem cells. Furthermore, the progeny of these cells reconstitute adult articular cartilage de novo, entirely substituting fetal chondrocytes. —Li, L. , Newton, P. T. , Bouderlique, T. , Sejnohova, M. , Zikmund, T. , Kozhemyakina, E. , Xie, M. , Krivanek, J., Kaiser, J., Qian, H. , Dyachuk, V. , Lassar, A. B. , Warman, M. L. , Barenius, B. , Adameyko, I. , Chagin, A. S. Superficial cells are self‐renewing chondrocyte progenitors, which form the articular cartilage in juvenile mice. FASEB J. 31, 1067–1084 (2017). www.fasebj. org
Children and Gender Inequality: Evidence from Denmark

Using Danish administrative data, we study the impacts of children on gender inequality in the labor market. The arrival of children creates a long-run gender gap in earnings of around 20 percent driven by hours worked, participation, and wage rates. We identify mechanisms driving these “child penalties” in terms of occupation, sector, and firm choices. We find that the fraction of gender inequality caused by child penalties has featured a dramatic increase over the last three to four decades. Finally, we show that child penalties are transmitted through generations, from parents to daughters, suggesting an influence of childhood environment on gender identity. (JEL D63, J13, J16, J22, J31, J71)
Effect of grain particle size on performance. 2. Grain texture interactions.

Diets were prepared with corn, wheat, or sorghum ground in a hammer mill and sieved to obtain coarse, medium, and fine particle size fractions. Their effect on broiler performance from hatch to 7 d and from 7 to 21 d of age was studied. The effect of particle size on the size and pH of the gastrointestinal organs was also determined. The three textures obtained for each grain were uniform in geometric mean diameter (GMD) and geometric standard deviation (GSD). Grain by texture interactions were not significant. Independent of grain source, the best performance was obtained with diets prepared from the medium texture. In these diets, the GMD of the grains varied from 1.13 to 1.23 mm and the GSD from 1.19 to 1.35. The fine fraction (GMD .57 to .67 mm) resulted in the lowest performance and that resulting from the coarse fraction (GMD 2.01 to 2.10 mm) was intermediate. At 7 and 21 d of age, gizzard weight and content were positively related to particle size. At the age of 21 d, duodenum weight and content was highest in chicks fed the fine diets. The pH of the gizzard content decreased with increasing grain particle size, whereas that of the small intestinal content increased. Some grain effects were also observed on the gastrointestinal tract. Gizzard weight was greatest in the cornfed birds. Wheat-fed chicks had the heavier intestines and contents. After overnight feed deprivation, feed consumption by 7-d-old chicks was related to the particle size during the first 2 h of refeeding, with greater intake of medium and coarse grains.
Intensified anticyclonic anomaly over the western North Pacific during El Niño decaying summer under a weakened Atlantic thermohaline circulation

It has been well documented that there is an anticyclonic anomaly over the western North Pacific (WNPAC, hereafter) during El Niño decaying summer. This El Niño‐WNPAC relationship is greatly useful for the seasonal prediction of summer climate in the WNP and East Asia. In this study, we investigate the modification of the El Niño‐WNPAC relationship induced by a weakened Atlantic thermohaline circulation (THC) in a water‐hosing experiment. The results suggest that the WNPAC during the El Niño decaying summer, as well as the associated precipitation anomaly over the WNP, is intensified under the weakened THC. On the one hand, this intensification is in response to the increased amplitude and frequency of El Niño events in the water‐hosing experiment. On the other hand, this intensification is also because of greater climatological humidity over the western to central North Pacific under the weakened THC. We suggest that the increase of climatological humidity over the western to central North Pacific during summer under the weakened THC is favorable for enhanced interannual variability of precipitation, and therefore favorable for the intensification of the WNPAC during El Niño decaying summer. This study suggests a possible modulation of the El Niño–Southern Oscillation‐WNP summer monsoon relationship by the low‐frequency fluctuation of Atlantic sea surface temperature. The results offer an explanation for the observed modification of the multidecadal fluctuation of El Niño‐WNPAC relationship by the Atlantic multidecadal oscillation.
A randomized orthogonal array-based procedure for the estimation of first- and second-order Sobol' indices

In variance-based sensitivity analysis, the method of Sobol' [Sensitivity analysis for nonlinear mathematical models. Math Model Comput Exp. 1993;1:407–414] allows one to compute Sobol' indices (SI) using the Monte Carlo integration. One of the main drawbacks of this approach is that estimating SI requires a number of simulations which is dependent on the dimension of the model of interest. For example, estimating all the first- or second-order SI of a d-dimensional function basically requires or independent input vectors, respectively. Some interesting combinatorial results have been introduced to weaken this defect, in particular by Saltelli [Making best use of model evaluations to compute sensitivity indices. Comput Phys Commun. 2002;145:280–297] and more recently by Owen [Variance components and generalized Sobol' indices. SIAM/ASA J Uncertain Quantification. 2013;1:19–41], but the quantities they estimate still depend linearly on the dimension d. In this paper, we introduce a new approach to estimate all the first- and second-order SI by using only two input vectors. We establish theoretical properties of such a method for the estimation of first-order SI and discuss the generalization to higher order indices. In particular, we prove on numerical examples that this procedure is tractable and competitive for the estimation of all first- and second-order SI. As an illustration, we propose to apply this new approach to a marine ecosystem model of the Ligurian sea (northwestern Mediterranean) in order to study the relative importance of its several parameters. The calibration process of this kind of chemical simulators is well known to be quite intricate, and a rigorous and robust – that is, valid without strong regularity assumptions – sensitivity analysis, as the method of Sobol' provides, could be of great help. This article has supplementary material online.
Electrical circuits RC, LC, and RL described by Atangana–Baleanu fractional derivatives

In this paper, the analytical solutions for the electrical series circuits RC, LC, and RL using novel fractional derivatives of type Atangana–Baleanu with non‐singular and nonlocal kernel in Liouville–Caputo and Riemann–Liouville sense were obtained. The fractional equations in the time domain are considered derivatives in the range α∈(0;1]; analytical solutions are presented considering different source terms introduced in the fractional equation. We solved analytically the fractional equation using the properties of Laplace transform operator together with the convolution theorem. On the basis of the Mittag–Leffler function, new behaviors for the voltage and current were obtained; the classical cases are recovered when α=1. Copyright © 2017 John Wiley & Sons, Ltd.
Normalized serum eosinophil peroxidase levels are inversely correlated with esophageal eosinophilia in eosinophilic esophagitis

SUMMARY Eosinophil peroxidase is an eosinophil-specific, cytoplasmic protein stored in the secondary granules of eosinophils. While eosinophil peroxidase deposition is increased in the esophagus in eosinophilic esophagitis (EOE), its potential role as a peripheral marker is unknown. This study aims to examine the relationship between serum eosinophil peroxidase and esophageal eosinophilia in eosinophilic esophagitis. Prospectively collected serum from 19 subjects with incident EoE prior to treatment and 20 non-EoE controls were tested for serum eosinophil peroxidase, eosinophilic cationic protein, and eosinophil derived neurotoxin using ELISA. Matching esophageal tissue sections were stained and assessed for eosinophil peroxidase deposition using a histopathologic scoring algorithm. Mean peripheral blood absolute eosinophil counts in eosinophilic esophagitis subjects were significantly elevated compared to controls (363 vs. 195 cells/μL,P = 0.008). Absolute median serum eosinophil peroxidase, eosinophil cationic protein, and eosinophil derived neurotoxin did not differ between groups; however, when normalized for absolute eosinophil counts, eosinophilic esophagitis subjects had significantly lower median eosinophil peroxidase levels (2.56 vs. 6.96 ng/mL per eos/μL,P = 0.002, AUC 0.79 (0.64, 0.94 95% CI)). Multivariate analysis demonstrated this relationship persisted after controlling for atopy. Esophageal biopsies from eosinophilic esophagitis subjects demonstrated marked eosinophil peroxidase deposition (median score 46 vs. 0,P < 0.0001). Normalized eosinophil peroxidase levels inversely correlated with esophageal eosinophil density (r = −0.41,P = 0.009). In contrast to marked tissue eosinophil degranulation, circulating eosinophils appear to retain their granule proteins in EoE. Investigations of normalized serum eosinophil peroxidase levels as a biomarker of EoE are ongoing.
Current state of the art for enhancing urine biomarker discovery

ABSTRACT Introduction: Urine is a highly desirable biospecimen for biomarker analysis because it can be collected recurrently by non-invasive techniques, in relatively large volumes. Urine contains cellular elements, biochemicals, and proteins derived from glomerular filtration of plasma, renal tubule excretion, and urogenital tract secretions that reflect, at a given time point, an individual’s metabolic and pathophysiologic state. Areas covered: High-resolution mass spectrometry, coupled with state of the art fractionation systems are revealing the plethora of diagnostic/prognostic proteomic information existing within urinary exosomes, glycoproteins, and proteins. Affinity capture pre-processing techniques such as combinatorial peptide ligand libraries and biomarker harvesting hydrogel nanoparticles are enabling measurement/identification of previously undetectable urinary proteins. Expert commentary: Future challenges in the urinary proteomics field include a) defining either single or multiple, universally applicable data normalization methods for comparing results within and between individual patients/data sets, and b) defining expected urinary protein levels in healthy individuals.
Effects of frequency of semen collection on quantitative and qualitative characteristics of semen in turkey breeder males.

The effects of various frequencies of semen collection on several quantitative and qualitative semen characteristics were investigated in adult turkey breeder males (30 to 40 wk of age). In Experiment 1, a total of 35 males were first trained for semen collection (twice a week for 2 consecutive wk), and then divided into five groups (seven males each), each group being collected either once every 2 wk, once every week, twice every week, three times every week (each for 4 wk) or five to seven times per week (each for 2 wk). Volume, sperm concentration, and sperm number per ejaculate were determined for each ejaculate. No significant differences between groups were observed for sperm concentration (P > 0.05), but males collected once every 2 wk, once per week, or twice per week had larger volumes than males collected at higher frequencies (P < 0.05). Thus there were significant differences for sperm number per ejaculate between groups (P < 0.05). Also, daily semen output (DSO) was markedly increased in males collected at the highest frequencies (e.g., DSO = 0.62 x 10(9) and 1.93 x 10(9) in males collected once and five times per week). Finally, in euthanatized birds (36 wk) no differences between groups were observed for body weight (25.8 +/- 1.7 kg), testicular weight (51.5 +/- 2.2 g), or total number of elongated spermatids per male (14.0 +/- 0.8 x 10(9)). In Experiment 2, 35 males were distributed into groups and collected under the same conditions as in Experiment 1. Besides quantitative analyses of ejaculates (volume, sperm concentration, and sperm per ejaculate), sperm viability between groups was also tested using the Sybr14/PI fluorescence test. Our results demonstrated: 1) a favorable effect of high semen collection frequencies on sperm viability and, 2) a marked decline in sperm viability during the first 2 d following a 2-d resting period in males collected five times a week. We concluded that turkey males express their optimal reproductive capacity more efficiently when semen collection is undertaken at a high rather than a low frequency.
Low temperature magnetic properties of Nd2Ru2O7

We present magnetic susceptibility, heat capacity, and neutron diffraction measurements of polycrystalline Nd2Ru2O7 down to 0.4 K. Three anomalies in the magnetic susceptibility measurements at 146, 21 and 1.8 K are associated with an antiferromagnetic ordering of the Ru4+ moments, a weak ferromagnetic signal attributed to a canting of the Ru4+ and Nd3+ moments, and a long-range-ordering of the Nd3+ moments, respectively. The long-range order of the Nd3+ moments was observed in all the measurements, indicating that the ground state of the compound is not a spin glass. The magnetic entropy of Rln2 accumulated up to 5 K, suggests the Nd3+ has a doublet ground state. Lattice distortions accompany the transitions, as revealed by neutron diffraction measurements, and in agreement with earlier synchrotron x-ray studies. The magnetic moment of the Nd3+ ion at 0.4 K is estimated to be 1.54(2)µB and the magnetic structure is all-in all-out as determined by our neutron diffraction measurements.
Artificial night lighting inhibits feeding in moths

One major, yet poorly studied, change in the environment is nocturnal light pollution, which strongly alters habitats of nocturnally active species. Artificial night lighting is often considered as driving force behind rapid moth population declines in severely illuminated countries. To understand these declines, the question remains whether artificial light causes only increased mortality or also sublethal effects. We show that moths subjected to artificial night lighting spend less time feeding than moths in darkness, with the shortest time under light conditions rich in short wavelength radiation. These findings provide evidence for sublethal effects contributing to moth population declines. Because effects are strong under various types of light compared with dark conditions, the potential of spectral alterations as a conservation tool may be overestimated. Therefore, restoration and maintenance of darkness in illuminated areas is essential for reversing declines of moth populations.
Histological Alterations in Common Carp (Cyprinus carpio Linnaeus, 1758) Gills as Potential Biomarkers for Fungicide Contamination

The present study aimed to investigate the histological alterations in common carp gills caused by a fosetyl-Al and fenamidone based fungicide tested in laboratory conditions at 30, 38 and 50 mg/L concentration. In general, all the tested concentrations activated compensatory-adaptive mechanisms, which caused pathological changes in the fish gills. Results showed different histological alterations in the gill structure, which included lamellar lifting, edema, proliferation of the glandular cells and epithelium, covering the gill filament, fusion and degenerative alterations. Blood circulatory system showed vasodilatation of the secondary lamellae and aneurysms. Overall, there was enhancement of the gill histological changes, which was dose-dependent, i.e., proportional to the increasing fungicide concentrations. Thus, based on the results, it was concluded that the histological alterations in common carp gills could be applied as possible biomarkers in risk assessment and monitoring programs for pesticide contamination of aquatic ecosystems.
Dynamic associations of network isolation and smoking behavior

Abstract Prevailing social network frameworks examine the association between peer ties and behaviors, such as smoking, but the role of social isolates is poorly understood. Some theories predict isolated adolescents are protected from peer influence that increases smoking, while others suggest isolates are more likely to initiate smoking because they lack the social control provided by peer friendships. Building on a growing literature that seeks to explain these contradictions by moving beyond a homogeneous understanding of isolation, we identify the relationship between smoking and three distinct dimensions of isolation: avoided (adolescents who do not receive ties), withdrawn (adolescents who do not send ties), and externally oriented (adolescents who claim close out-of-grade friends). We examine the co-evolutionary effects of these dimensions and cigarette smoking using an autoregressive latent trajectory model with PROSPER Peers, a unique, longitudinal network dataset. These data include students (47% male and 86% white) from rural Iowa and Pennsylvania, ranging successively from grades 6–12 in eight waves of data. We find avoided isolation is associated with decreased subsequent smoking in high school. Smoking increases subsequent avoided and withdrawn isolation, but decreases external orientation.
Evaluating an Action Threshold-Based Insecticide Program on Onion Cultivars Varying in Resistance to Onion Thrips (Thysanoptera: Thripidae)

Abstract Onion thrips, Thrips tabaci Lindeman (Thysanoptera: Thripidae), is a highly destructive pest of onion, Allium cepa L. , and its management relies on multiple applications of foliar insecticides. Development of insecticide resistance is common in T. tabaci populations, and new strategies are needed to relax existing levels of insecticide use, but still provide protection against T. tabaci without compromising marketable onion yield. An action threshold-based insecticide program combined with or without a thrips-resistant onion cultivar was investigated as an improved approach for managing T. tabaci infestations in commercial onion fields. Regardless of cultivar type, the average number of insecticide applications needed to manage T. tabaci infestations in the action-threshold based program was 4.3, while the average number of sprays in the standard weekly program was 7.2 (a 40% reduction). The mean percent reduction in numbers of applications following the action threshold treatment in the thrips-resistant onion cultivar, ‘Advantage’, was 46.7% (range 40–50%) compared with the standard program, whereas the percentage reduction in applications in action threshold treatments in the thrips-susceptible onion cultivar, ‘Santana’, was 34.3% (range 13–50%) compared with the standard program, suggesting a benefit of the thrips-resistant cultivar. Marketable bulb yields for both ‘Advantage’ and ‘Santana’ in the action threshold-based program were nearly identical to those in the standard program, indicating that commercially acceptable bulb yields will be generated with fewer insecticide sprays following an action threshold-based program, saving money, time and benefiting the environment.
Aggregation Effects and Population-Based Dynamics as a Source of Therapy Resistance in Cancer

Objective: Evolution of resistance allows cancer cells to adapt and continue proliferating even when therapy is initially very effective. Most investigations of treatment resistance focus on the adaptive phenotypic properties of individual cells. We propose that the resistance of a single cell to therapy may extend beyond its own phenotypic and molecular properties and be influenced by the phenotypic properties of surrounding cells and variations in cell density. Similar variation exists in population densities of animals living in groups and can significantly affect the outcome of an external threat. Methods: We investigate aggregation effects in cancer therapy using Darwinian models that integrate phenotypic properties of individual cells and common population effects found in nature to simulate the dynamics of resistance and sensitivity in the diverse cellular environments within cancers. Results: We demonstrate that the density of cancer cell populations can profoundly influence response to chemotherapy independent of the properties of individual cells. Most commonly, these aggregation effects benefit the tumor allowing cells to survive even with phenotypic properties that would render them highly vulnerable to therapy in the absence of population effects. Conclusion: We demonstrate aggregation effects likely play a significant role in conferring resistance to therapy on tumor cells that would otherwise be sensitive to treatment. Significance: The potential role of aggregation in outcomes from cancer therapy has not been previously investigated. Our results demonstrate these dynamics may play a key role in resistance to therapy and could be used to design evolutionarily-enlightened therapies that exploit aggregation effects to improve treatment outcomes.