Miracle-dz/UniFAR-FTUs huggingface dataset:
TLR2 Expression in Relation to IL-6 and IL-1β and their Natural Regulators Production by PMN and PBMC in Patients with Lyme Disease

Recently, it has been reported that TLR2 on macrophages plays a unique role in the inflammatory response and host defense to infection with Borrelia burgdorferi (Bb) which is an etiologic agent of Lyme disease. Experimental studies show that PMNs also play an essential role in infection control by Bb. However, there is no available data about TLR2 expression on PMN in the course of Lyme disease. In the present study, TLR2 expression and production of IL-1β and IL-6 as well as their natural regulators (sIL-1RII, IL-1Ra and sIL-6Rα, sgp130, resp) by PMN of peripheral blood in patients with Lyme disease were examined. For the purpose of comparison, the same activity of autologous peripheral blood mononuclear cells (PBMCs) was estimated. An effect of rhIL-15 on TLR2 and cytokine secretion was also studied. Increased TLR2 expression in unstimulated neutrophils suggests an important role of these cells in mechanism recognition of B burgdorferi in patients with Lyme disease. The relationship between IL-1β and IL-6 as well as their regulators by unstimulated PMN and PBMC, observed in the present study, may lead to enhanced IL-6- and to inhibition of IL-1β-mediated reactions in this patient group. Changes in the TLR2 expression after rhIL-15 stimulation appear to have a favorable effect on mechanism recognition of Bb. The relations between IL-6 and its regulators (sIL-6Rα and sgp130) as well as between IL-1β and its regulators (IL-1Ra and sIL-1RII) after rhIL-15 stimulation may lead to enhanced IL-1β- and IL-6-mediated inflammatory reactions in the course of Lyme disease.
An Application of SaTScan to Evaluate the Spatial Distribution of Corner Kick Goals in Major League Soccer

Identifying strategy that helps increase the number of goals in soccer is paramount to success. Opportunities exist to increase success in set pieces such as free kicks and corner kicks. We examined all corner kicks attempted during the 2010 Major League Soccer season to assess whether goals scored off of corner kicks were randomly spatially distributed. We separated the 18-yard box into 66, three by four yard boxes. A spatial scan statistic implemented in SaTScan, varied at-risk percentages to assess areas with higher than expected rates of goals scored. We examined data from 1859 corner kicks with an overall goal rate of 2.2%. A single box directly in the center of the box, 6-9 yards from goal was the only box with significantly higher rates of goals scored (5.0%) than expected. This result did not vary after adjusting for potential confounders’ home field, kick trajectory or time of game. Our results, which consider goal rates, are consistent with previous research that suggest the most aggregate goals are scored in an area 6-12 yards from goal. Future research is needed to account for player movement on corner kick attempts.
MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger Datasets.

We present the latest version of the Molecular Evolutionary Genetics Analysis (Mega) software, which contains many sophisticated methods and tools for phylogenomics and phylomedicine. In this major upgrade, Mega has been optimized for use on 64-bit computing systems for analyzing larger datasets. Researchers can now explore and analyze tens of thousands of sequences in Mega The new version also provides an advanced wizard for building timetrees and includes a new functionality to automatically predict gene duplication events in gene family trees. The 64-bit Mega is made available in two interfaces: graphical and command line. The graphical user interface (GUI) is a native Microsoft Windows application that can also be used on Mac OS X. The command line Mega is available as native applications for Windows, Linux, and Mac OS X. They are intended for use in high-throughput and scripted analysis. Both versions are available from www.megasoftware. net free of charge.
The Effects of Dyadic Discussion on Earwitness Recall

Some 112 introductory psychology students served as subjects in a mock kidnapping study. Subjects overheard a telephone conversation by a perpetrator discussing his crime and were tested for their reconstructions of the incident either 10 min later or 48 hr later. Dyadic discussion followed by collaborative recall did not increase the overall accuracy of individual's reconstructions of the incident, but it did produce consistent, concise, and conventional accounts of the incident. Reliably, more fabrications were found in the dyadic-discussion-individual-recall group than in the recalls of the collaborative-dyad group and the no-discussion-individual-recall group. Estimations of the duration of the incident also were reliably inferior in the dyadic-discussion-individual-recall condition. Given only the voice of the perpetrator, subjects' judgments of height, weight, and age were estimated poorly. Rated descriptions of voice attributes and personality traits of the perpetrator generally were not influenced.
A Comparison of Selected ‘Serious’ and ‘Popular’ British, Canadian, and United States Newspaper Coverage of Female and Male Athletes Competing in the Centennial Olympic Games

This study compares how selected ‘serious’ and ‘popular’ newspapers from three countries covered female and male athletes during the Centennial Olympic Games, 1996. From Canada, the Globe and Mailand Toronto Star; from Great Britain, The Timesand the Daily Mail; and from the United States, the New York Timesand USA Todaywere examined. Content analysis was used to compare all the articles and photographs of female and male athletes on the front pages and the sports sections of all six newspapers. Although differences were found, generally the results showed that, compared to their respective participation rates, female and male athletes competing in the Centennial Olympic Games received an equitable amount of coverage. Qualitative analyses indicated that female athletes received a comparable coverage with their male peers in article descriptors of their ‘physical appearance/attire’, ‘strength/athleticism’, ‘psychological characteristics’, and ‘family role’, and in ‘competing’, ‘non-competing’, ‘active’, and ‘posed’ photographs. This study confirmed that female athletes receive more newspaper coverage when they compete in major international competitions such as the Olympic Games. Reasons for the reasonably equitable amount of newspaper coverage of female athletes are outlined, with suggestions for improvement of newspaper coverage of female athletes.
Toward a Linguistic Theory of Speech Acts

constraining the form and function of transformations in linguistic theory; lexicon and base component; the interactions of distinct systems of rules within grammars. The topics dealt cover boundedness of transformations, the "trace theory" of movement rules, autonomy of syntax, the X-bar con-vention, the structure of the lexicon, and language learn- ability. This book discusses both the motivations for, and the problems with, the performative hypothesis in generative semantics. It attempts to tighten the theory of generative semantics in order to make it empirically testable, and examines the results about speech acts in the tightened theory in two ways: first, it explores the range of illocutionary force which interrogative- and imperative-form sentences encode; and second, it compares the view of illocutionary force and perlocu- tionary effect in this linguistic theory with the thinking of analytic philosophers. theory. The approach taken is a struct syntac- tic one in that semantic considerations are ignored except insofar as they provide validation for an analysis arrived at on the basis of purely syntactic considerations. Particular emphasis is placed on the interrelationships between constraints on grammars and the Iearnability of languages. This book explores the question of abstractness in underlying representations, providing up-to-date explanations of this and other current issues in phonological theory. Every problem is amply illustrated with concrete data from a variety of languages. CONTENTS: The problem of the abstractness of underlying representations. The non-phonetic basis of phonology. Constraints on phonological representations. Natural rule interactions. The multiple application problem. The role of derivational history in phonology. This volume presents some of the historical developments, theoretical controversies, and major research findings and applications from the points of view of psychology, socio-logy, linguistics and education, as they relate to various aspects of bilingualism. The contributions to the book cover three distinct but overlapping focuses of concern: the consequences of bilingualism at the level of the individual; the effects of bilingualism on social interaction and society; and the significance of bilingualism at the national and international levels.
Family-friendly benefits?

Abstract Data from the Canadian Workplace and Employee Survey (1999–2002) is used to assess the take-up of family-friendly benefits provided by employers. We distinguish benefit availability from the actual use of benefits and are able to account for worker selection into firms. We find that selection is important to understand the take-up of family-friendly benefits and that there is little difference between genders regarding benefit use. Overall, it seems that some family-friendly benefits (like flexible time) are relatively little help in the management of work-family conflict, while others (like childcare or eldercare) are unavailable to those who would benefit from them the most.
Root surface biomodification with an Er:YAG laser for the treatment of gingival recession with subepithelial connective tissue grafts.

BACKGROUND/AIM Root surface biomodification has been used to treat gingival recession and periodontitis. The principle for this procedure is that removing the smear layer from the root surfaces exposes collagen fibers, which leads to improved healing. Clinical studies generally have failed to find any improvement in clinical parameters when using such agents. The aim of this study was to evaluate and compare the outcome of gingival recession therapy using the subepithelial connective tissue graft (SCTG) with or without Er:YAG laser application for root surface biomodification. MATERIALS AND METHODS Twenty-four teeth in 12 patients with Miller class I and II recession were treated with SCTG with (test group) or without (control group) the application of an Er:YAG laser (2 Hz, 60 mJ/pulse, 40 s, with air spray). Clinical attachment level (CAL), recession depth (RD), recession width (RW), and probing depth (PD) were measured at baseline and 6 months postsurgery. RESULTS There were no significant differences between test and control groups (p > 0.05). Postoperatively, significant root coverage, gains in CAL, and highly significant increases in the RW were observed in both groups. For test and control groups, the average root coverage was 80% and 86%, respectively (p > 0.05), and complete root coverage was 75% and 67%, respectively. CONCLUSIONS The present study showed that root surface conditioning with an Er:YAG laser does not enhance the results achieved when SCTG was performed alone.
Counter-story, resistance and reconciliation in online narratives of women in recovery from problem gambling

Based on discourse analysis of website postings to an online gender-specific support group over a 30-month period, this study examines the context and narrative forms through which women tell the stories of their experience of problem gambling and recovery. In response to the hegemony of men-dominated groups and dominant ideologies, women seeking support for their recovery create both online and offline symbolic communities for gendered expression of experience. The oral tradition of Gamblers Anonymous is referenced and reflected in the website postings, providing a coherent narrative structure that is valued in western culture. The online forum references a pragmatic approach that places women's solutions in the public domain, rendering these experiences visible, significant and transformative. A hypothetical model is proposed in which creation of symbolic community and learning to tell a coherent narrative mediate progress from chaos to social and moral reconciliation.
Association between anti‐Pfs48/45 reactivity and P. falciparum transmission‐blocking activity in sera from Cameroon

Pfs48/45, a sexual stage parasite protein doublet of P. falciparum, is a target of antibodies which inhibit the development of the parasite in the mosquito. Twenty‐eight (54%) out of 52 sera of gametocyte carriers from Cameroon reduced infectivity in the mosquito membrane feeding bioassay to less than 20% of the controls. These 52 sera were analysed by competition ELISAs for the presence of antibodies capable of competing the binding of six monoclonal antibodies (MoAbs) directed against five different epitopes on Pfs48/45. The percentage of these 52 Cameroon sera that competed with one of the MoAbs ranged from 13% (epitope I) to 33% (epitope IIc). Comparison of activity in the transmission‐blocking assay ( ≥80%) and in the Pfs48/45 competition ELISA show a relative specificity of 100% (24 of 24) and a relative sensitivity of 75% (21 of 28). Non‐blocking sera showed no competition with any of the MoAbs. These MoAbs were further used to study the diversity of epitopes among isolates of P. falciparum using a two‐site ELISA. MoAbs against epitope I, III and V reacted with four different isolates whereas epitope II could be subdivided into three epitopes. None of the isolates reacted with MoAb 3G12 (epitope IV). Using these four different isolates, the competition ELISA titre varies from 1/20 to 1/80 and no significant differences are found between the isolates except for epitope II where only three out of 11 positives for epitope IIa were also positive for epitope IIc.
WRITING WITH WIKIS: A CAUTIONARY TALE OF TECHNOLOGY IN THE CLASSROOM

Learning to write a scholarly literature review is often difficult for undergraduatestudents. This teaching note examines a pilot study of BSW students' use ofa wiki to collaboratively write a literature review in a research course (N=36). Students expressed negative responses toward the assignment and were reluctantto use the wiki. Their responses are explored through an examination oftheir activity on the wiki, discussion group feedback, comments in the courseevaluation, and unsolicited remarks made by students. Common criticismsraised by students were time-management issues, group coordination concerns,and assignment parameters. Suggestions for improving and modifying theassignment are discussed.
Nurses' Expectations, Experiences and Attitudes towards the Intervention of a ‘No Lifting Policy’

Nurses' Expectations, Experiences and Attitudes towards the Intervention of a ‘No Lifting Policy’: Inga‐Lill Engkvist, Department of Medicine and Health, Faculty of Health Sciences, Linköping University, Sweden—The aim of the study was to evaluate expectations and attitudes towards a No Lifting Policy programme, the “No Lift system”, among nurses at hospitals where an introduction of the intervention was planned (PreNLS hospitals), and to make a comparison with nurses' experiences and attitudes at one hospital where the intervention had already been implemented (NLS hospital). A cross‐sectional study of nurses at two PreNLS hospitals and one NLS hospital was performed. Most nurses at both the PreNLS hospitals and the NLS hospital were positive or very positive to the intervention. The expected and experienced obstacles differed between nurses at the PreNLS hospitals and the NLS hospital; however, there was more agreement concerning benefits. The most frequently expected obstacles at the PreNLS hospitals were organisational issues and obstacles related to the facilities, while most obstacles identified at the NLS hospital concerned specific transfers or were patient‐related. A decrease in the number of injuries was the most often considered benefit among most nurses. Nurses at the NLS hospital rated their physical exertion as lower in seven out of nine specific patient transfers compared with nurses at the PreNLS hospitals. They also reported increased well‐being at work and an improved ability to manage their daily work. The comprehensive approach and participatory design, including all levels of staff and extensive support from the nurses' own union and management, is probably one important explanation for the positive attitudes and successful introduction of the intervention.
Trellis Coded Modulation for 4800 to 9600 bps Transmission Over a Fading Satellite Channel Dariush Divsalar

The combination of trellis coding and multiple phase-shift-keyed (MPSK) signaling with the addition of asymmetry to the signal set is discussed with regard to its suitability as a modulation/coding scheme for the fading mobile satellite channel. For MPSK, introducing nonuniformity (asymmetry) into the spacing between signal points in the constellation buys a further improvement in performance over that achievable with trellis coded symmetric MPSK, all this without increasing the average or peak power, or changing the bandwidth constraints imposed on the system. Whereas previous contributions have considered the performance of trellis coded modulation transmitted over an additive white Gaussian noise (AWGN) channel, the emphasis in this paper is on the performance of trellis coded MPSK in the fading environment. The results will be obtained by using a combination of analysis and simulation. It will be assumed that the effect of the fading on the phase of the received signal is fully compensated for either by tracking it with some form of phase-locked loop or with pilot tone calibration techniques. Thus, our results will reflect only the degradation due to the effect of the fading on the amplitude of the received signal. Also, we shall consider only the case where interleaving/deinterleaving is employed to further combat the fading. This allows for considerable simplification of the analysis and is of great practical interest. Finally, the impact of the availability of channel state information on average bit error probability performance is assessed.
High mobility group box chromosomal protein 1 as a nuclear protein, cytokine, and potential therapeutic target in arthritis.

High mobility group box chromosomal protein 1 (HMGB-1), a DNA binding protein, is an intracellular protein that facilitates DNA bending, stabilizes nucleosome formation, and modulates the interactions of regulatory molecules with their targets. Recent evidence has revealed that HMGB-1 is also a cytokine, because it 1) is released from activated monocyte/macrophages, 2) mediates delayed endotoxin lethality, 3) activates macrophages, 4) stimulates inflammation in vivo, and 5) is a therapeutic target in diverse animal models of inflammatory disease (1–4). Our review accompanies the report by Taniguchi and colleagues (5), in this issue of Arthritis & Rheumatism, of a new study of HMGB-1 in the pathogenesis of arthritis. We summarize here the history of research on HMGB-1 as an intracellular protein and discuss in more detail a rapidly growing body of evidence that implicates HMGB-1 as a cytokine that can mediate inflammation and arthritis. Some important new findings are highlighted, and a series of observations that warrant additional study are raised. The molecular basis of the cytokine activity of HMGB-1 and the biochemistry of this potentially important therapeutic target are discussed.
Is Biologically Inspired Invention Different?

The paradigm of biologically inspired design views nature as a vast library of robust, efficient and multifunctional designs, and espouses the use nature as a source of analogues for inspiring novel designs in domains of interest such as architecture, computing, engineering, etc. Over the last generation, biologically inspired design has emerged as a major movement in engineering, architectural, and systems design, pulled in part by the need for environmentally sustainable design and pushed partly by the desire for creativity and innovation in design. An important question is whether biologically inspired design is fundamentally different from other kinds of analogy- based creative processes. This question is critical because the computational theories, techniques and tools we need to develop to support biologically inspired design depend on the nature of the task itself. In this paper, we first summarize some of our empirical findings about biologically inspired design, then derive a task model for it, and finally posit that biologically inspired design indeed is a novel methodology for multiple reasons.
Information Processing Deficits In Clumsy Children

Abstract Abnormal clumsiness was investigated within the Framework of an information processing model using chronometric techniques. Eight clumsy and eight normal children were tested in two experiments in which between-group comparisons were made of the functioning of the perceptual and response selection processes. The processing of both proprioceptive and visual stimulus information was investigated. Clumsy children were found to process proprioceptive information more slowly than do normal children. However, in this modality, neither the perceptual nor response selection processes were effectively manipulated. By comparison, no difference in the rate of processing of visual information was found. In this modality both processes were effectively manipulated and groups were not differentially affected. Thus, the findings suggest that abnormal clumsiness is associated with an information processing dysfunction which is specific to the proprioceptive modality. Moreover, the findings suggest that clumsines.
Electrospray of 1-Butyl-3-Methylimidazolium Dicyanamide Under Variable Flow Rate Operations

The ionic liquid 1-butyl-3-methylimidazolium dicyanamide ([Bmim][DCA]) is a propellant candidate for a standalone electrospray thruster or a dual-mode propulsion system. Characterization of positive polarity ions produced by [Bmim][DCA] capillary emitters with a nominal extraction voltage of 2.0 kV is presented, followed by predictions of propulsion performance. Flow rates from 0.27 to 2.18 nL/s are used to investigate the impact variations in the flow parameter have on the electrospray plume. Measurements indicate the presence of Bmim([Bmim][DCA])n+ (n=0, 1, 2, 3, 4) cation species plus droplet contributions. At 0.27 nL/s, the n=1 species dominates the mass spectrum contributing 56.5% of the total intensity, while at 2.18 nL/s, the dominant species is n=4, comprising 40.7%. Based on the retarding potential analysis, ions emitted from the capillary are formed below the emitter potential of 500 eV. Angular distributions indicate the broadening of both the beam current and mass distribution for increasin.
A New Use of Douglas-Rachford Splitting and ADMM for Identifying Infeasible, Unbounded, and Pathological Conic Programs

In this paper, we present a method for identifying infeasible, unbounded, and pathological conic programs based on Douglas-Rachford splitting, or equivalently ADMM. When an optimization program is infeasible, unbounded, or pathological, the iterates of Douglas-Rachford splitting diverge. Somewhat surprisingly, such divergent iterates still provide useful information, which our method uses for identification. In addition, for strongly infeasible problems the method produces a separating hyperplane and informs the user on how to minimally modify the given problem to achieve strong feasibility. As a first-order method, the proposed algorithm relies on simple subroutines, and therefore is simple to implement and has low per-iteration cost.