Miracle-dz/UniFAR-FTUs huggingface dataset:
A Survey of Topology‐based Methods in Visualization

This paper presents the state of the art in the area of topology‐based visualization. It describes the process and results of an extensive annotation for generating a definition and terminology for the field. The terminology enabled a typology for topological models which is used to organize research results and the state of the art. Our report discusses relations among topological models and for each model describes research results for the computation, simplification, visualization, and application. The paper identifies themes common to subfields, current frontiers, and unexplored territory in this research area.
A case series of 72 neonates with renal vein thrombosis

Summary Neonatal renal vein thrombosis (RVT) is a well-recognized clinical entity which is associated with serious morbidity. However, current information regarding RVT has been restricted to case reports and small case series. In this study, it was our objective to describe patient demographics, clinical presentation, location and risk factors of RVT. For our study design, we looked at a case series of 72 neonates with RVT referred to the 1-800-NO-CLOTS consultation service between 9/1996 and 8/2001. Data on age, gender, associated conditions, prothrombotic disorders, family history, location of the thrombosis, diagnostic techniques, and treatment were prospectively recorded using a standardized form. Our results show that RVT affected males (65%, CI 52-76%) significantly more often than females (35%, CI 24-48%). Median age at presentation was 2 days (0-21 days). RVT was unilateral in 72% (left side: 67%, CI 49-81%; right side: 33%, CI 19-51%), and bilateral in 28%. The majority (83%) had at least one associated condition: Prematurity (54%), central venous lines (17%), a diabetic mother (13%), asphyxia (6%), infections (6%). Prothrombotic testing was performed in 21 neonates. Activated protein C resistance was found in 8 children (38%), other defects in three. This is the largest case series of neonatal RVT to date. Data from the study show that i) male infants are affected twice as often as females and ii) there appears to be a left-sided predominance of neonatal RVT. Neonatal RVT is only infrequently associated with the presence of a catheter as compared to thrombosis at other sites. The majority of infants have associated conditions with prematurity being most frequent. A small subset of neonates were screened for prothrombotic abnormalities and 50% of the children screened were positive.
Recognition and velocity computation of large moving objects in images

Two one-dimensional time sequences are generated from the projections of the two-dimensional sequence on the x and y axes. Then the two-dimensional fast Fourier transform for the generated time sequences is computed. A peak in the spectrum for the selected spatial frequency is detected. The temporal frequency at which the peak is detected gives an estimate of the velocity of the moving object. Analytical formulations for large moving objects in a time sequence with zero background are presented. An algorithm is given for velocity formulation. >
A Glia-Derived Signal Regulating Neuronal Differentiation

Astrocytes are present in large numbers in the nervous system, are associated with synapses, and propagate ionic signals. Astrocytes influence neuronal physiology by responding to and releasing neurotransmitters, but the mechanisms that establish the close interaction between these cells are not defined. Here we use hippocampal neurons in culture to demonstrate that vasoactive intestinal polypeptide (VIP) promotes neuronal differentiation through activity-dependent neurotrophic factor (ADNF), a protein secreted by VIP-stimulated astroglia. ADNF is produced by glial cells and acts directly on neurons to promote glutamate responses and morphological development. ADNF causes secretion of neurotrophin 3 (NT-3), and both proteins regulate NMDA receptor subunit 2A (NR2A) and NR2B. These data suggest that the VIP–ADNF–NT-3 neuronal–glial pathway regulates glutamate responses from an early stage in the synaptic development of excitatory neurons and may also contribute to the known effects of VIP on learning and behavior in the adult nervous system.
Application of Analytical Hierarchy Process Approach for Service Quality Evaluation in Radiology Departments: A Cross-Sectional Study

Background: Radiology department as a service provider organization requires realization of quality concept concerning service provisioning knowledge, satisfaction and all issues relating to the customer as well as quality assurance and improvement issues. At present, radiology departments in hospitals are regarded as income generating units and they should continuously seek performance improvement so that they can survive in the changing and competitive environment of the health care sector. Objectives: The aim of this study was to propose a method for ranking of radiology departments in selected hospitals of Tehran city using analytical hierarchical process (AHP) and quality evaluation of their service in 2015. Materials and Methods: This study was an applied and cross-sectional study, carried out in radiology departments of 6 Tehran educational hospitals in 2015. The hospitals were selected using non-probability and purposeful method. Data gathering was performed using customized joint commission international (JCI) standards. Expert Choice 10.0 software was used for data analysis. AHP method was used for prioritization. Results: “Management and empowerment of human resources’’ (weight = 0.465) and “requirements and facilities” (weight = 0.139) were of highest and lowest significance respectively in the overall ranking of the hospitals. MS (weight = 0.316), MD (weight = 0.259), AT (weight = 0.14), TS (weight = 0.108), MO (weight = 0.095), and LH (0.082) achieved the first to sixth rankings respectively. Conclusion: The use of AHP method can be promising for fostering the evaluation method and subsequently promotion of the efficiency and effectiveness of the radiology departments. The present model can fill in the gap in the accreditation system of the country’s hospitals in respect with ranking and comparing them considering the significance and value of each individual criteria and standard. Accordingly, it can predict an integration of qualitative and quantitative criteria involved and thereby take a decisive step towards further efficiency and effectiveness of the health care evaluation systems.
Is there a relationship between Wolfram syndrome carrier status and suicide?

Wolfram syndrome (WFS) is a rare, autosomal recessive neurodegenerative disorder. An increased risk of psychiatric disorders and suicide has been reported for heterozygote carriers. In this study we investigated whether mutations in the WFS gene are associated with suicide in the general population. The gene for WFS (WFS1) has recently been mapped to chromosome 4p16.1, and its genomic structure has been characterized. We screened the entire WFS1 ORF in a panel of 100 completed suicides, 60 blood donors not known to have psychiatric illness, and 100 donors with a negative history of depression or suicidal behavior. We did not find evidence of an increased incidence of WFS carriers in the suicide panel and concluded that WFS1 carrier status is not a significant contributor to suicide in the general population. Screening of this highly polymorphic gene resulted in the detection of 33 variants, 13 of which cause amino acid changes. Seven of these changes have not been previously reported and six were unique to our suicide panel.
English Object Alternations : A Unified Account

A hallmark of the English verb lexicon is the availability of multiple argument realization options for many English verbs. Studies of the English verb lexicon have drawn attention to one facet of this phenomenon: the availability of a range of object alternations (Levin 1993)—alternate realizations of the VP-internal arguments of apparently triadic verbs. One of the best-known of these alternations is the locative alternation, which comes in “putting” and “removing” subtypes, as illustrated in (1) and (2).
Adenovirus infection: A potential risk for developing intussusception in pediatric patients

The pathogenesis of intussusception without obvious anatomical leading points remains unclear. The objective of this study was to determine a feasibility of association between certain gastroenteritis viruses and intussusception. This was a prospective cohort study. Forty intussusception cases and 136 acute gastroenteritis controls with comparable age and gender were separately consecutively enrolled and relevant clinical data of both groups were recorded. The clinical specimens collected from all patients were screened for adenovirus, rotavirus, norovirus, and astrovirus by PCR and RT‐PCR using specific primers. The genomes of detected viruses were characterized further to identify their genotypes by nucleotide sequencing. In 40 intussusception cases, adenovirus, rotavirus, and norovirus were detected in 12 (30.0%), 2 (5.0%), and 2 (5.0%), respectively while astrovirus was undetectable. In contrast, 136 acute gastroenteritis patients, adenovirus, rotavirus, and norovirus were detected in 11 (8.1%), 24 (17.7%), and 24 (17.7%) patients, respectively and again astrovirus was undetectable. The detection of adenovirus in intussusception patients was significantly higher than those in the control group (P < 0.001) with an odd ratio of 4.87 (95%CI: 1.95, 12.16). Interestingly, molecular analysis of adenovirus genome demonstrated that all of adenovirus detected in intussusception patients belonged to adenovirus C. This could be a potential risk factor or pathogenesis for developing intussusception in the cases of those without apparent anatomical leading points. J. Med. Virol. 88:1930–1935, 2016. © 2016 Wiley Periodicals, Inc.
The representation of instructions in working memory leads to autonomous response activation: Evidence from the first trials in the flanker paradigm

The authors examined whether instructions can lead to autonomous response activation even without practice. Eriksen and Eriksen's (1974) flanker compatibility paradigm was used to show that the flanker compatibility effect (FCE) is already present in the first trials following the stimulus–response instructions, before any of the stimuli have been repeated. This first-trials FCE was present even when participants were strongly motivated to ignore the flankers, and it disappeared under conditions of high working-memory (WM) load. The findings suggest that intention, formed by instructions, is involved in forming representations in WM that operate like a prepared reflex (Woodworth, 1938). The implications of the finding to intentionality and frontal lobe functions are discussed.
Developmental process in mental handicap: a generative structure approach

A radical argument is presented that it is plausible to look at the condition of mental handicap as entailing dynamic cognitive processes which may be available to some degree of therapeutic intervention at a fundamental level. An overview of some broad aspects of mental handicap is presented and it is argued that much of the subject of mental handicap is based on assumptions which may not be justified. On the assumption that in normal infancy play is a powerful medium for promoting developmental change, aspects of the mentally handicapped child's inability to play is examined and discussed. This is done by adopting the Piagetian notion of decentration and showing how the concept has explanatory value for looking at change in the severely, or profoundly mentally handicapped child. A model of aspects of the process is developed and implemented as a computer simulation. This model entails he processes of "Integration and Differentiation" of hierarchical chunks. The prospects and usefulness of a developmental curriculum as a framework within which to work with the profoundly and severely mentally retarded is discussed. The notions of Integration and Differentiation are applied to systems of sensori-motor competence and presented as a candidate for a curriculum. A presentation of the Uzgiris & Hunt scales serves to provide the user with the means to understand where the child is "at" in the curriculum. The computer simulation is further developed to show how it could be extended to provide explanations for the effects of success and failure upon developmental process. The model provides an insight into the nature of stereotypy and the implications of the model are explored in a therapy undertaked with a mentally handicapped and withdrawn child. The relationship between the understanding gained here and the processes of normal mothering is introduced. The theme of the mothering process is develcped apd explored as a means of providing the mentally Nandi Gaped child with the experience of success that section 3 suggests is the means for promoting change. This is demonstrated via several case accounts. The transactional interface between the intractable organic and the potentially more plastic cognitive/social process is tentatively explored by a discussion of "eye contact". Finally an evaluative framework for the possible implications of the work are discussed.
Microarrays complement culture methods for identification of bacteria in endodontic infections.

The aim of this study was to investigate the microbial composition of necrotic root canals using culture methods and microarray technology. Twenty uniradicular teeth with radiographic evidence of periapical bone loss and with no previous endodontic treatment were selected for this study. For molecular diagnosis a DNA chip with 20 different species-specific, 16S-rDNA-directed catcher probes was used. The microorganisms most frequently detected by the DNA chip were: Micromonas micros, Fusobacterium nucleatum ssp. , Tannerella forsythia, Treponema denticola, Veillonella parvula, Eubacterium nodatum, Porphyromonas gingivalis, Actinomyces odontolyticus, and Streptococcus constellatus. As expected, additional important bacterial taxa were found by culture analysis, but microorganisms such as T. forsythia and T. denticola could not be identified. In conclusion, microarrays may provide significant additional information regarding the endodontic microbiota by detecting bacterial species that are otherwise difficult or impossible to culture.
A conceptual model and process for client-driven agile requirements prioritization

Continuous customer-centric requirements reprioritization is essential in successfully performing agile software development. Yet, in the agile RE literature, very little is known about how agile reprioritization happens in practice. Generic conceptual models about this process are missing, which in turn, makes it difficult for both practitioners and researchers to reason about requirements decision-making at inter-iteration time. This paper presents a Grounded Theory study on agile requirements prioritization methods to yield a conceptual model for understanding the inter-iteration prioritization process in terms of inputs and outcomes. The latter is derived by using qualitative empirical data, published earlier by other authors. Such a conceptual model makes explicit the concepts that are used tacitly in different agile requirements prioritization methods and can be used for structuring future empirical investigations about this topic.
Detect of Sublethal Damage with Cyclic Deformation of Erythrocyte in Shear Flow

The deformation of an erythrocyte has been observed microscopically in the shear flow to detect the sublethal damage of an erythrocyte in vitro. A rheoscope system has been manufactured to observe the deformation of the suspended erythrocytes in the shear flow. The rheoscope consists of a pair of parallel disks and an inverted phase-contrast microscope. The human erythrocytes were suspended in the dextran aqueous solution, which has high viscosity. The erythrocytes are sheared in the Couette flow between a pair of counter rotating disks. The experiments with the rheoscope show following results. The erythrocytes deform from a biconcave to an ellipsoidal shape. The erythrocytes deform periodically at the double frequency of tank tread motion of the membrane of the deformed erythrocyte, when erythrocytes have the sublethal damage on the membrane.
Early Human Speciation, Brain Expansion and Dispersal Influenced by African Climate Pulses

Early human evolution is characterised by pulsed speciation and dispersal events that cannot be explained fully by global or continental paleoclimate records. We propose that the collated record of ephemeral East African Rift System (EARS) lakes could be a proxy for the regional paleoclimate conditions experienced by early hominins. Here we show that the presence of these lakes is associated with low levels of dust deposition in both West African and Mediterranean records, but is not associated with long-term global cooling and aridification of East Africa. Hominin expansion and diversification seem to be associated with climate pulses characterized by the precession-forced appearance and disappearance of deep EARS lakes. The most profound period for hominin evolution occurs at about 1.9 Ma; with the highest recorded diversity of hominin species, the appearance of Homo (sensu stricto) and major dispersal events out of East Africa into Eurasia. During this period, ephemeral deep-freshwater lakes appeared along the whole length of the EARS, fundamentally changing the local environment. The relationship between the local environment and hominin brain expansion is less clear. The major step-wise expansion in brain size around 1.9 Ma when Homo appeared was coeval with the occurrence of ephemeral deep lakes. Subsequent incremental increases in brain size are associated with dry periods with few if any lakes. Plio-Pleistocene East African climate pulses as evinced by the paleo-lake records seem, therefore, fundamental to hominin speciation, encephalisation and migration.
A Payment-based Incentive and Service Differentiation Mechanism for Peer-to-Peer Streaming Broadcast

We proposes a novel payment-based incentive mechanism for peer-to-peer (P2P) live media streaming. Using this approach, peers earn points by forwarding data to others; the data streaming is divided into fixed length periods, during each of which peers compete with each other for good parents (data suppliers) for the next period in a first-price auction like procedure using their points. We design a distributed algorithm to regulate peer competitions, and consider various individual strategies for parent selection from a game theoretic perspective. We then discuss possible strategies that can be used to maximize a peer's expected media quality by planning different bids for its substreams. Finally, in order to encourage off-session users to keep staying online and continue contributing to the network, we develop an optimal data forwarding strategy that allows peers to accumulate points that can be used in future services. Simulations results show that proposed methods effectively differentiate the media qualities received by peers making different contributions (which originate from, for example, different forwarding band-widths or servicing times), and at the same time maintaining a high system-wide performance
Perceived Challenges Faced by Nurses in Home Health Care Setting: A Qualitative Study

ABSTRACT Background: Home care has gradually become a nursing model for nursing care. The nurses’ experiences of challenges they have in home care have remained unknown. The aim of this study was to explore the hidden aspects of challenges related to home care in Iran. Methods: This study was conducted to explore the challenges of home nursing care using a qualitative content analysis method. Purposeful and snowball sampling methods were used for sampling. The study was conducted from September 2016 to September 2017 in the provinces of Khorasan and Tehran in Iran. Semi-structured interviews were conducted on 33 nurses who were providing home care. After data saturation, the data were analyzed. Results: The data analysis led to the development of five main categories of “difficult instances “, “economic problems”, “professional barriers”, “social difficulties”, and “bureaucratic tension”. Conclusion: The results of this study showed how nurses faced with a variety of challenges in home care and how they were different from hospitals. Facilitating the nursing processes, supporting home care, and recruiting nurses that had the potential to cope with the existing stressful factors and economic incentives can increase the quality of home care.
STUDIES ON THE LEUKOCYTOSIS AND LYMPHOCYTOSIS INDUCED BY BORDETELLA PERTUSSIS

The 24 hr volume flow, cell concentration, and total cell output of thoracic duct fluid from mice with pertussis-induced hyperlymphocytosis were markedly reduced when compared with values obtained in normal animals. An increase in the number of circulating lymphocytes occurred in several of the pertussis-treated mice despite the presence of an indwelling thoracic duct cannula. The drainage from such animals also showed a reduced cell concentration and total cell output. It is suggested that lymphocyte recirculation may be minimal in pertussis-induced lymphocytosis, and the evidence obtained also suggests that lymphocytes may enter the blood stream by direct routes during the course of the reaction.
Relationship between periodontal disease and mortality in patients treated with maintenance hemodialysis.

BACKGROUND The relationship between periodontitis and outcomes in patients treated with long-term hemodialysis is controversial. Our previous work suggests that periodontitis is associated with malnutrition and inflammation. Here, we hypothesize that periodontitis is associated with mortality in hemodialysis patients. STUDY DESIGN Prospective observational study. SETTING & PARTICIPANTS 253 patients undergoing hemodialysis at a single hospital-based dialysis facility. PREDICTOR Severity of periodontal disease (mild, moderate, or severe based on oral examination of 6 teeth). OUTCOMES & MEASUREMENTS All-cause and cardiovascular mortality during a 6-year follow-up after an oral health examination of index teeth. RESULTS During the 6-year follow-up, 102 patients died. Death occurred in 70.6%, 41.8%, and 24.0% of patients with severe, moderate, and mild/no periodontitis, respectively. Using mild/no periodontitis as the reference group and adjustment for demographic characteristics, comorbid conditions, and selected laboratory values, HRs for all-cause mortality were 1.39 (95% CI, 0.83-2.34) and 1.83 (95% CI, 1.04-3.24) for moderate and severe periodontitis, respectively. HRs for cardiovascular mortality were not statistically significant. LIMITATIONS Single assessment of periodontal disease severity. CONCLUSIONS For patients undergoing long-term hemodialysis, periodontitis is associated with increased risk of death. Clinical trials are required to determine whether treatment of periodontitis decreases mortality.