Miracle-dz/UniFAR-FTUs huggingface dataset:
[Inferior vena cava filters. Indications and results in 111 patients].

BACKGROUND Anticoagulation is the treatment of choice for deep vein thrombosis and pulmonary embolism. Occasionally this treatment is contraindicated or fails to prevent pulmonary embolism. In these patients, inferior cava vein interruption is indicated and filter insertion is the procedure commonly performed. AIM To report the results of inferior cava vein filter insertions in 111 patients. PATIENTS AND METHODS A retrospective review of patients in whom inferior cava vein filters were inserted was performed. RESULTS During the period 1983-1997, filters were inserted in 111 patients (56 female) aged 15 to 93 years old. Indications were pulmonary embolism with contraindication or failure of anticoagulation therapy or poor respiratory function (58 patients), deep vein thrombosis and contraindication for anticoagulation (32 patients) and other indications in 20 patients. In 47 patients, treated before 1993, the insertion required a cut-down. Since then, a percutaneous approach was used in the remaining 64 cases. Three insertion attempts failed, all using cut-down. One of these patients died due to a massive pulmonary embolism. In 88% of the patients the jugular vein was the access site and in 10 patients, the filter was deliberately deployed above the renal veins. There was no mortality or complications. Patients were followed during a maximal period of 147 months and 27 died of unrelated disorders. Survival at 5 and 10 years was 63 and 47% respectively. Symptomatic inferior cava vein obstruction was detected in 5 patients during the follow up period. CONCLUSIONS Inferior cava vein filter insertion is a safe measure to prevent pulmonary embolism and its consequences.
Patterns of biomechanical demands are associated with musculoskeletal pain in the beginning of professional life: a population-based study.

OBJECTIVES This study aimed to describe patterns of occupational biomechanical demands in the beginning of professional life and to quantify their association with the presence and intensity of regional musculoskeletal pain. METHODS Cross-sectional data from 21-year-old participants were collected during the third wave of the EPITeen cohort study (N=1733, 37.5% were workers). Ten different work-related biomechanical tasks were characterized. Latent class analysis was conducted to identify empirical patterns of occupational biomechanical demands. The presence and intensity of regional musculoskeletal pain in the previous year were also evaluated. RESULTS Four patterns of occupational biomechanical demands were found: "low demands", "sitting demands", "repetitive and asymmetric demands", and "high and vibrational demands". When compared to workers with low demands, those with repetitive and asymmetric demands or high and vibrational demands presented 80% higher adjusted odds ratio (OR adj) of reporting neck/shoulder pain. High and vibrational demands occupations were significantly associated with upper-/lower-back pain in comparison to low demands [OR adj1.80, 95% confidence interval (95% CI%) 1.09-2.96]. In addition, workers with sitting demands were more likely to report any or severe upper-/lower-back pain [OR adj1.56 (95% CI 0.99-2.45) and 1.66 (95% CI 1.03-2.66), respectively] when compared to those with low demands. CONCLUSIONS Patterns of high work-related physical demands were associated with the presence of neck/shoulder pain and severity of upper-/lower-back pain. This emphasizes that even short-term biomechanical exposures at the workplace may be involved in the etiology of musculoskeletal complaints.
Optimal two-level speed assignment for real-time systems

Reducing energy consumption is one of the main concerns in the design and implementation of embedded real-time systems. For this reason, the current generation of processors allows to vary voltage and operating frequency to balance computational speed and energy consumption. This technique is called dynamic voltage scaling (DVS). When applying DVS to hard real-time systems, it is important to provide the worst-case computational requirement; otherwise the timing constraints may be violated. However, the probability of a task executing for its worst-case execution time is very low. In this paper, we show how to exploit probabilistic information about the execution time of a task in order to reduce the energy consumed by the processor. Optimal speed assignments and transition points are found using a very general model for the processor. The model accounts for the processor idle power and time/energy overheads due to frequency transitions. We also show how these results apply to some significant cases.
Using gnome wide data for protein function prediction by exploiting gene ontology relationships

Many new therapeutic techniques depend not only on the knowledge of the molecules participating in the biological phenomena but also their biochemical function. Advancements in prediction of new proteins are immense if compared with the annotation of functionally unknown proteins. To accelerate the personalized medicine effort, computational techniques should be used in a smart way to accurately predict protein function. In this paper, we propose and evaluate a technique that utilizes integrated biological data from different online databases. We use this information along-with Gene Ontology (GO) relationships of functional annotations in a wide-ranging way to accurately predict protein function. We integrate PPI (Protein Protein Interactions) data, protein motifs information, and protein homology data, with a semantic similarity measure based on Gene Ontology to infer functional information for unannotated proteins. Our method is applied to predict function of a subset of homo sapiens species proteins. The integrated approach with GO relationships provides substantial improvement in precision and accuracy when compared to functional links without GO relationships. We provide a comprehensive assignment of annotated GO terms to many proteins that currently are not assigned any function.
An International Comparison of Female and Male Students' Attitudes to the Use of Animals

Simple Summary We surveyed university students in 11 Eurasian countries for their attitudes to animals, using an internet-based questionnaire to which 1,902 female and 1,530 male student responded from 102 universities. Across countries female students had greater concern for animal welfare and rights than males, but especially so in more gender empowered countries. One contributing factor appeared to be the greater association of females than males with pets, and a possible outcome was greater female avoidance of meat consumption, especially red meat. Abstract Previous research has demonstrated that in households where the male partner is more dominant, there is convergence in male and female attitudes towards animals, whereas if the female partner is empowered they exhibit greater empathy towards animals than the male partner. We tested this theory of ‘female empowered empathy’ internationally in a survey of female and male students' attitudes towards use of animals, conducted in 11 Eurasian countries: China, Czech Republic, Great Britain, Iran, Ireland, South Korea, Macedonia, Norway, Serbia, Spain and Sweden. Gender empowerment was estimated for each country using the Gender Empowerment Measure designed by the United Nations. The survey was administered via the internet in universities within countries, and 1,902 female and 1,530 male student responses from 102 universities were received. Respondents rated the acceptability of 43 major concerns about human use of animals, and the importance of 13 world social issues, including animal protection, environmental protection and sustainable development. Females had greater concern for animal welfare and rights than males. There was a positive correlation between the Gender Empowerment Measure and the ratio of female to male concern for animal welfare and rights, but not for other world issues. Thus in countries where females were more empowered, principally Sweden, Norway and Great Britain, females had much greater concern than males for animal issues, whereas in other countries the responses of males and females were more similar. Across countries female students were more likely to avoid meat and less likely to avoid eggs, milk and seafood than male students, and were more likely to have kept pets than males. Females rated cats as more sentient than males did. The results demonstrate that females have greater concern for animal welfare and rights than males, and that this is more likely to be expressed in countries where females are relatively empowered, suggesting that ‘emancipated female empathy’ operates across countries as well as at a local level.
Sound pressure generated in an external-ear replica and real human ears by a nearby point source.

A rubber replica has a pinna, concha, and auditory meatus with dimensions comparable with those of real human ears. At the eardrum position, there is provision for a totally reflecting termination (hard wall) or for various eardrum impedance networks. The replica is mounted in a rigid plane, and a point source at a distance of 8 cm provides sound with various angles of incidence over the frequency range 1–15 kHz. The sound pressure is measured with a probe‐tube microphone at selected positions in the open canal and at the center of a plug closing the ear‐canal entrance (“meatus‐blocked” condition). The response with open canal and the response with blocked meatus have virtually identical angular dependence up to 12 kHz. From 2–7 kHz, there is substantial acoustic gain at the eardrum position associated with a fundamental canal resonance (M1) and a second mode largely controlled by a depth resonance of the concha (M2). Pressure distributions in the canal and concha are given for M1, M2, and three other modes. Limited data for six real ears with open and blocked canal are in good agreement with replica measurements up to 7 kHz. At 8 kHz, however, the on‐axis response of real ears passes through a sharp minimum that is either removed to a higher frequency or is largely absent with the sound source above the axis.
Ieee Transactions on Knowledge and Data Engineering , Vol. X, No. X, Xxx 200x Taper: a Two-step Approach for All-strong-pairs Correlation Query in Large Databases

Given a user-specified minimum correlation threshold and a market basket database with ¡ items and ¢ transactions, an all-strong-pairs correlation query finds all item pairs with correlations above the threshold. However, when the number of items and transactions are large, the computation cost of this query can be very high. In this paper, we identify an upper bound of Pearson's correlation coefficient for binary variables. This upper bound is not only much cheaper to compute than Pearson's correlation coefficient but also exhibits a special monotone property which allows pruning of many item pairs even without computing their upper bounds. A Two-step All-strong-Pairs corrElation queRy (TAPER) algorithm is proposed to exploit these properties in a filter-and-refine manner. Furthermore, we provide an algebraic cost model which shows that the computation savings from pruning is independent or improves when the number of items is increased in data sets with common Zipf or linear rank-support distributions. Experimental results from synthetic and real data sets exhibit similar trends and show that the TAPER algorithm can be an order of magnitude faster than brute-force alternatives.
Proteomic analysis of protein changes developing in rat hippocampus after chronic antidepressant treatment: Implications for depressive disorders and future therapies

It is recognized that monoamine reuptake inhibitors (MARIs) exert beneficial effects in the treatment of major depression and general anxiety disorder. The aim of this study was to identify proteins regulated by this class of antidepressant using a proteome differential profiling approach. Either venlafaxine or fluoxetine was administered systemically to adult rats for 2 weeks, and protein patterns from rat hippocampal cytosolic extracts were compared by two‐dimensional gel electrophoresis. Silver‐stained protein spots displaying differential expression were identified by mass spectrometry. Thirty‐three protein spots were modulated by both drug treatments compared to controls. The classification of several proteins that were sorted by function suggested convergent pathway activities for both MARIs at the post‐receptor level. These included proteins associated with neurogenesis (insulin like growth factor 1 (IGF‐1), glia maturation factor [GMF]‐β), outgrowth/maintenance of neuronal processes (hippocampal cholinergic neurostimulating peptide [HCNP], PCTAIRE‐3), and with neural regeneration/axonal guidance collapsin response mediator protein (CRMP‐2) systems. Other modulated proteins indicated an increase in neuronal vesicular cell trafficking and synaptic plasticity (Ras‐related protein 4a (Rab4a), Ras‐related protein 1b (Rab1b), heat shock protein 10 [HSP10]), as well as neurosteroidogenic (hydroxysteroid sulfotransferase A) and possible anti‐apoptotic (dimethylargininase‐1 L‐N,N‐dimethylarginine dimethylaminohydrolase‐1 [DDAH‐1], pyruvate dehydrogenase‐E1 [PDH‐E1], antioxidant protein‐2 [AOP‐2]) pathway‐mediated regulatory events. Parallel studies to investigate further the effects of venlafaxine and fluoxetine on adult hippocampal neurogenesis in vivo by quantitative bromodeoxyuridine immunolabeling revealed a significant drug‐induced increase in the proliferation rate and long‐term survivability of progenitor stem cells located in the subgranular zone. These data suggest that MARIs share wide‐ranging proteome changes within the hippocampal formation, beyond 5‐HT/NE neurotransmission. This may reflect long‐term functional adaptations required for antidepressant activity. © 2004 Wiley‐Liss, Inc.
Validation of a High-Pressure Liquid Chromatography and Fluorescence Polarization Immunoassay for the Determination of Methadone in Canine Plasma

Methadone is a synthetic opiate derivative that possesses analgesic activity. A modified fluorescence polarization immunoassay (FPIA) method and a high-pressure liquid chromatography (HPLC) method with UV detection were compared for measurement of concentrations of methadone in canine plasma following intravenous and oral methadone administration. The mean ± SD for accuracy (deviation from actual concentration) and precision (coefficient of variation) when methadone-fortified canine plasma was evaluated with the FPIA method were 3.9 ± 3.2% and 4.4 ± 2.9%, respectively. The accuracy and precision of the HPLC method were 6.2 ± 5.2% and 7.7 ± 3.9%, respectively. The limit of quantification for the FPIA and HPLC methods were 25 and 20 ng/mL, respectively. The coefficient of determination (r2) between FPIA and HPLC analysis was 0.94 when plasma from dogs dosed with methadone was evaluated. FPIA provides a rapid, sensitive, and specific measurement of methadone in canine plasma following oral and intravenous administration.
Interaction of the AMPA receptor subunit GluR2/3 with PDZ domains regulates hippocampal long-term depression

The interaction of PDZ domain-containing proteins with the C termini of α-amino-3-hydroxy-5-methylisoxazolepropionate (AMPA) receptors has been suggested to be important in the regulation of receptor targeting to excitatory synapses. Recent studies have shown that the rapid internalization of AMPA receptors at synapses may mediate, at least in part, the expression of long-term depression (LTD). We have previously shown that phosphorylation of Ser-880 on the AMPA receptor GluR2 subunit differentially regulated the interaction of GluR2 with the PDZ domain-containing proteins GRIP1 and PICK1. Here, we show that induction of LTD in hippocampal slices increases phosphorylation of Ser-880 within the GluR2 C-terminal PDZ ligand, suggesting that the modulation of GluR2 interaction with GRIP1 and PICK1 may regulate AMPA receptor internalization during LTD. Moreover, postsynaptic intracellular perfusion of GluR2 C-terminal peptides that disrupt GluR2 interaction with PICK1 inhibit the expression of hippocampal LTD. These results suggest that the interaction of GluR2 with PICK1 may play a regulatory role in the expression of LTD in the hippocampus.
DEPORTISTAS OLÍMPICOS Y ESTRATEGIAS DE INSERCIÓN LABORAL * Propuesta teórica, método y avance de resultados

The article deals with Olympic Spanish sportpeople’s labour market insertion. Strategy and transition are the main theoretical concepts. We are using both phenomenological and figurational approach. In depth interviews have been conducted. Results focus on sportspeople’s adopted strategies: consciousness of future, studies, to safe money, to plan sport retirement, to invest “sport capital”. Conclusions, mainly take into account labour market insertion differences and similarities between sport people and other population.
Interest in services among prostate cancer patients receiving androgen deprivation therapy

Treatment side effects and decreased quality of life associated with androgen deprivation therapy (ADT) suggest the need for supportive services for prostate cancer (PC) patients receiving ADT. Nonetheless, uptake of services is low, suggesting that PC patients' preferences are not being addressed. We examined interest in supportive services and predictors of interest among 118 PC patients receiving ADT. Overall interest in services was associated with lower quality of life (p=0.01). The majority of participants expressed interest in informational services (70%), with a minority (22%) expressing interest in psychosocial services. Interest in psychosocial services was associated with younger age (p=0.02), and shorter duration of ADT (p<0.04), but was unrelated to psychological distress or social support. Although most men (68%) reported that they would prefer not to take medication for depression, 75% would do so if advised by their physician. Overall, results suggest that PC patients on ADT prefer individualized informational support. Substantial interest (61%) in Oncolink, an internet‐based informational resource, suggests the Internet may provide an acceptable mode of service delivery. Health care providers should consider integrating increased informational support into routine care and, more generally, consider patient preferences in prioritizing and designing support services. Copyright © 2003 John Wiley & Sons, Ltd.
Understanding Theories of Criminal Victimization

Current theories of victimization have generated a sizable body of empirical research, mostly within the last two decades. The two most widely known perspectives, lifestyle-exposure and routine activities theories, have been the object of much current thinking and empirical testing, but their maturation has been hampered by many of the same problems impeding theories of criminality. These include inadequate attention to variation by type of crime, compartmentalized thinking, poor links between theory and data, inadequate measures of key concepts, and failure to specify clearly functional relationships between sets of variables. Many of these problems can be addressed by closer examination of the interrelationships among victims, offenders, and criminal situations. Victimization theories should be incorporated into comprehensive integrated theories of crime.
Illuminating musical lifeworlds: phenomenological narratives of the musical lifeworlds of five senior secondary school students

This study investigates the musical lifeworlds of five musically dedicated senior secondary high school students in order to explicate meaning structures within their 'musical ways of being'. These structures illuminate the participants' musical lives as they are 'lived' and each idiosyncratic and unique relationship with music. While the study illuminates broad features of the way 'musical lives are lived' it also highlights two specific lifeworld realms. The first is the realm of lived musical experiences that are described as deeply felt, formative, transformative or epiphanic. Interpretation of these experiences provides insight into the ways that the participants had commenced musical lives. The second is the realm of lived experience with different types of music learning processes. Illuminating music teaching and learning processes from the perspective of each student is designed to contribute to the ongoing dialogue and discussion of music's place in formal institutional settings and informal, student initiated communities of practice. Data were generated from interviews with the participants, their parents and music teachers, and also from observations of musical performances, researcher field notes and reflexive journal entries. A 're-storying' process was then conducted using narrative analyses and syntheses and phenomenological interpretation. The re-storied research texts were then structured and presented as composite 'portraits' of each participant. The project promotes narrative and phenomenological ‘ways of thinking’ about music, music experience and processes of inquiry. I have explored a pragmatic, embodied and situated experience of narrative and phenomenological ‘ways of thinking’ rather than operating from a priori principles and abstract theories about them. This pragmatic engagement is made visible by the insertion of vignettes, at strategic points, of my situated, lived experiences and learning processes with being a narrative and phenomenological thinker. The findings suggest that by illuminating the essential meanings within individual musical lifeworlds, music may be perceived not as a thing, but an active process and a socially mediated, integrated structure of self. Sensitivity to and empathy with the ways students live musical lives may assist educators to achieve situational appropriateness whilst teaching. Understanding the ways that life and music are inseparable will help to counter the alienating tendency in Western music education to view music as an autonomous aesthetic object that is independent of the experiencer. The findings suggest that music educators engage in ‘pedagogical self-transformation’ by adopting a narrative and phenomenological stance. This transformation, I argue, promotes empathy where educators are primarily engaged as ‘enhancers of musical identity’ and ‘interpreters of the musical texts of life’.
Screen Printable Flexible BiTe–SbTe-Based Composite Thermoelectric Materials on Textiles for Wearable Applications

This paper presents the optimization of a bismuth tellurium (Bi<sub>1.8</sub>Te<sub>3.2</sub>)-antimony tellurium (Sb<sub>2</sub>Te<sub>3</sub>)-based thermoelectric generator (TEG) fabricated by screen-printing technology on flexible polyimide (Kapton) and textile substrates. New formulations of screen printable thermoelectric pastes are presented with optimized composition, curing conditions, and printing parameters. The modifications of the thermoelectric materials enable them to be successfully deposited on flexible textile substrates. The optimized values of resistivity of the BiTe and SbTe thick films on Kapton were 9.97 × 10<sup>-3</sup> and 3.57 × 10<sup>-3</sup> Ω · cm, respectively. The measured figure of merit at room temperature was 0.135 and 0.095 for BiTe and SbTe thick films on Kapton, respectively. The dimension of each printed thermoleg was 20 mm×2 mm×70.5 μm. For the TEG on Kapton, the printed assembly comprising eight thermocouples was coiled up and generated a voltage of 26.6 mV and a maximum power output of 455.4 nW at a temperature difference of 20 °C. For a printed TEG on textile, the maximum power output reached 2 μW from the same temperature difference.
Creating minds: an anatomy of creativity seen through the lives of freud

Since it was first published in 1993, Creating Minds has served as a peerless guide to the creative self. Now available as a paperback reissue with a new introduction by the author, the book uses portraits of seven extraordinary individuals to reveal the patterns that drive the creative process--and to demonstrate how circumstance also plays an indispensable role in creative success.