Miracle-dz/UniFAR-FTUs huggingface dataset:
The submillimeter C and CO lines in Henize 2-10 and NGC 253

The purpose of this paper is to describe a method for determining a cooling template for galaxies, using nearby galax- ies, and applicable to future observations of distant galaxies. We observed two starburst galaxies (NGC 253 and Henize 2-10) with the Caltech Submillimeter Observatory in the rotational lines of carbon monoxide 12 CO(J = 3-2), (J = 6-5) and (J = 7-6) for both, and also 12 CO(J = 4-3) and 13 CO(J = 3-2) for Henize 2-10 and in the 3 P2- 3 P1 fine-structure transitions of atomic carbon (CI) at 809 GHz for NGC 253. Some of these observations have been made previously, but the present multitransition study (including data found in the literature) is the most complete to date for the two galaxies. From these observations, we have derived the properties of the warm and dense molecular gas in the galaxy nuclei. We used an LTE analysis and an LVG radiative transfer model to determine physical conditions of the interstellar medium in both sources and predicted integrated line proper- ties of all CO transitions up to 12 CO(15-14). We found the observations to be in good agreement with a medium characterized by Tk ≈ 50-100 K, 12CO 13CO ≈ 30, n(H2) 10 4 cm −3 and N( 12 CO) = 3.5 ± 1 × 10 18 cm −2 for Henize 2-10 and characterized by Tk ≈ 70-150 K, 12CO 13CO ≈ 40, n(H2) 10 4 cm −3 and N( 12 CO) = 1.5 ± 0.5 × 10 19 cm −2 for NGC 253. A PDR model has also been used and here the data are well fitted (within 20%) by a model cloud with a gas density of n(H) = 8.0 ± 1 × 10 5 cm −3 and an incident FUV flux of χ ≈ 20 000 for Henize 2-10. For NGC 253, we deduced n(H) = 3.0 ± 0.5 × 10 5 cm −3 and χ ≈ 20 000 for the modelled cloud. The physical properties of warm gas and CO cooling curves of the target galaxies are compared with those measured for the nucleus of the Milky Way and the Cloverleaf QSO. The gas properties and CO cooling curve are similar for the two starburst galaxies and the Cloverleaf QSO while the Milky Way nucleus exhibits lower excitation molecular gas.
An Exploration of the Relationships Among Individual and Interpersonal Goal Pursuit and Hedonic and Eudaimonic Well-being

Studies in the areas of goal pursuit and well-being suggest that the goals people work toward in their daily lives are important contributors of well-being. However, research to date has focused primarily on aspects of the individual in goal pursuit even though goals are not pursued in isolation. In fact, there is evidence that this emphasis on the individual, particularly salient in Western cultures, has negative consequences at both the individual and community levels. With regard to well-being, data have indicated that it is best represented as two dimensional, including hedonic and eudaimonic well-being. However, the research on personal goals has primarily focused on hedonic well-being of the individual. Overall, hedonic well-being appears to be more related to affective experience, whereas eudaimonic well-being appears to be more comprehensive and related to topics like purpose in life, self-acceptance, and positive relations with others. The theoretical framework of Virtue Ethics posits that social affiliations are essential for human beings to flourish and experience eudaimonia, and this study examines that premise. A two-step approach to structural equation modeling was used to contribute to the extant literature on goal pursuit and well-being by 1) exploring the individual and interpersonal dimensions of goal pursuit and their relationships to hedonic and eudaimonic well-being and 2) exploring the interpersonal dimensions of goal pursuit as a mediator of the relationship between individual dimensions of goal pursuit and eudaimonic well-being. The retained structural model from the two-step approach included Efficacy (an Individual Dimension of Goal Pursuit) and Generativity (an Interpersonal Dimension of Goal Pursuit). Results demonstrated that Efficacy and Generativity were both significantly related to Hedonic and Eudaimonic Well-being; however, Generativity was more strongly related to Eudaimonic than Hedonic Well-being. These findings were consistent with the premise of Virtue theory, that those engaged in goal pursuit with or on behalf of others are more likely to experience higher levels of eudaimonic well-being. Future research should include further exploration of the Interpersonal Dimensions of Goal Pursuit and well-being specifically by focusing on improving measurement for the Interpersonal Dimensions of Goal Pursuit, Hedonic, and Eudaimonic Well-being. Access to the full-text PDF is restricted to University of Miami servers.
Parameter estimation for text analysis

Presents parameter estimation methods common with discrete proba- bility distributions, which is of particular interest in text modeling. Starting with maximum likelihood, a posteriori and Bayesian estimation, central concepts like conjugate distributions and Bayesian networks are reviewed. As an application, the model of latent Dirichlet allocation (LDA) is explained in detail with a full derivation of an approximate inference algorithm based on Gibbs sampling, in- cluding a discussion of Dirichlet hyperparameter estimation. Finally, analysis methods of LDA models are discussed.
Emotional Consequence of Telling a Lie

: Generally, arousal increases when telling a lie, as indicated in psychophysiological studies about lie detection. But the emotional valence induced by lying is unknown, though intuition indicates that it may be negative. Indeed, the EDA (electrodermal activity), used in such studies, only shows arousal changes during an emotional response. In this study, we used two tasks in order to examine the emotional valence induced by lying. At the beginning, in the deceptive task, participants answered “no” to every question regarding the nature of displayed playing cards. Therefore, they told a lie about specific cards. Their EDA was recorded all along the task. Secondly, in the figure estimation task, they assessed pictures positively or negatively after looking at playing cards visibly or subliminally as prime stimuli. We expected them to tend to estimate figures negatively when cards relevant to deception had been previously shown. This would mean that an affective priming effect due to telling a lie actually occurred. All in all, this effect was found only when prime stimuli had been displayed visibly. This result suggests that lying per se induces negative emotions even without motivation or punishment due to lying. Furthermore, we found that such effect was all the more obvious in participants whose EDA changes were salient while lying.
The Natural History of the Arboreal Ant, Crematogaster ashmeadi

Abstract The arboreal ant, Crematogaster ashmeadi Emery (Hymenoptera: Formicidae), is the most dominant arboreal ant in the pine forests of the coastal plain of northern Florida. The majority of pine trees harbor a colony of these ants. The colonies inhabit multiple chambers abandoned by bark-mining caterpillars, especially those of the family Cossidae, in the outer bark of living pines. They also inhabit ground level termite galleries in the bark, often locating the queen in galleries. The density of chambers and ants is highest in the base of the tree and drops sharply with height on the trunk. Because chambers are formed in the inner layer of bark, they gradually move outward as more bark layers are laid down, eventually sloughing off the tree's outer surface. Chambers have a mean lifetime of about 25 yr. The abundant chambers in pine bark are excavated by a small population of caterpillars and accumulate over decades. Ant colonies also inhabit abandoned galleries of woodboring beetles in dead branches in the crowns of pines. Because newly mated queens found colonies in abandoned woodboring beetle galleries in the first dead branches that form on pine saplings, C. ashmeadi is dependent on cavities made by other insects throughout its life cycle, and does little if any excavation of its own. Mature colonies nest preferentially in chambers greater than 10 cm2 in area, a relatively rare chamber size. In natural pine forests, this does not seem to limit the ant's populations. Founding queens containabout 50% fat and lose about half of their dry weight during the claustral period, converting approximately half of this lost weight into progeny. The claustral period is about 40 to 50 days at 27°C. Mature colonies contain several tens of thousands of workers (est. up to 80,000), and have a life expectancy of 10 to 15 years. Each colony occupies an entire tree, and sometimes two trees if they are close together. Within a colony, there is a single queen capable of laying up to 450 eggs/day during the warm season. Such queens weigh 12 to 18 mg, have 50 to 60 active ovarioles and 120 to 600 vitellogenic oocytes in their ovaries. Mature colonies begin producing sexual brood in late April or early May. Sexual adults are present from late May through June. Mating flights commence in June and most sexuals have left their natal nests by late July. Female sexuals are an especially large investment; the energetic content of a single, flight-ready female sexual is almost 20 times that of a worker. The newly mated queen sequesters a mean of 2.64 × 106 sperm in her spermatheca, a supply that should last her for 16 years at the observed reproductive rates.
Classifying scientific disciplines in Slovenia: A study of the evolution of collaboration structures

We explore classifying scientific disciplines including their temporal features by focusing on their collaboration structures over time. Bibliometric data for Slovenian researchers registered at the Slovenian Research Agency were used. These data were obtained from the Slovenian National Current Research Information System. We applied a recently developed hierarchical clustering procedure for symbolic data to the coauthorship structure of scientific disciplines. To track temporal changes, we divided data for the period 1986–2010 into five 5‐year time periods. The clusters of disciplines for the Slovene science system revealed 5 clusters of scientific disciplines that, in large measure, correspond with the official national classification of sciences. However, there were also some significant differences pointing to the need for a dynamic classification system of sciences to better characterize them. Implications stemming from these results, especially with regard to classifying scientific disciplines, understanding the collaborative structure of science, and research and development policies, are discussed.
Proteolysis of Enteric Cell Villin by Entamoeba histolytica Cysteine Proteinases*

Invasive microorganisms efface enteric microvilli to establish intimate contact with the apical surface of enterocytes. To understand the molecular basis of this effacement in amebic colitis, we seeded Entamoeba histolytica trophozoites on top of differentiated human Caco-2 cell layers. Western blots of detergent lysates from such cocultures showed proteolysis of the actin-bundling protein villin within 1 min of direct contact of living trophozoites with enterocytes. Mixtures of separately prepared lysates excluded detergent colysis as the cause of villin proteolysis. Caspases were not responsible as evidenced by the lack of degradation of specific substrates and the failure of a specific caspase inhibitor to prevent villin proteolysis. A crucial role for amebic cysteine proteinases was shown by prevention of villin proteolysis and associated microvillar alterations through the treatment of trophozoites before coculture with synthetic inhibitors that completely blocked amebic cysteine proteinase activity on zymograms. Moreover, trophozoites of amebic strains pSA8 and SAW760 with strongly reduced cysteine proteinase activity showed a reduced proteolysis of villin in coculture with enteric cells. Salmonella typhimurium and enteropathogenic Escherichia coli disturb microvilli without villin proteolysis, indicating that the latter is not a consequence of the disturbance of microvilli. In conclusion, villin proteolysis is an early event in the molecular cross-talk between enterocytes and amebic trophozoites, causing a disturbance of microvilli.
Design and TCAD simulations of planar active-edge pixel sensors for future XFEL applications

We report on the design and TCAD simulations of planar active-edge pixel sensors within the INFN PixFEL project. These devices are intended as one of the building blocks for the assembly of a multilayer, four-side buttable tile for X-ray imaging applications in future Free Electron Laser facilities. The requirements in terms of very wide dynamic range and tolerance to extremely high ionizing radiation doses call for high operation voltages. A comprehensive TCAD simulation study is presented, aimed at the best trade-offs between the minimization of the edge region size and the sensor breakdown voltage.
Equality of Opportunity in Supervised Learning

We propose a criterion for discrimination against a specified sensitive attribute in supervised learning, where the goal is to predict some target based on available features. Assuming data about the predictor, target, and membership in the protected group are available, we show how to optimally adjust any learned predictor so as to remove discrimination according to our definition. Our framework also improves incentives by shifting the cost of poor classification from disadvantaged groups to the decision maker, who can respond by improving the classification accuracy. We enourage readers to consult the more complete manuscript on the arXiv.
Temporal Query Answering in DL-Lite with Negation

Ontology-based query answering augments classical query answering in databases by adopting the open-world assumption and by including domain knowledge provided by an ontology. We investigate temporal query answering w.r. t. ontologies formulated in DL-Lite, a family of description logics that captures the conceptual features of relational databases and was tailored for efficient query answering. We consider a recently proposed temporal query language that combines conjunctive queries with the operators of propositional linear temporal logic (LTL). In particular, we consider negation in the ontology and query language, and study both data and combined complexity of query entailment.
A Role for the B7-1/B7-2:CD28/CTLA-4 Pathway During Negative Selection1

Although costimulation plays an important role in activating naive T cells, its role in negative selection is controversial. By following thymocyte deletion induced by endogenous superantigens in mice lacking B7-1 and/or B7-2, we have identified a role for both B7-1 and B7-2 in negative selection. Studies using CD28-deficient and CD28/CTLA-4-double-deficient mice have revealed that either CD28 or another as yet undefined coreceptor can mediate these B7-dependent signals that promote negative selection. Finally, CTLA-4 delivers signals that inhibit selection, suggesting that CTLA-4 and CD28 have opposing functions in thymic development. Combined, the data demonstrate that B7-1/B7-2-dependent signals help shape the T cell repertoire.
Spectral norm of circulant type matrices with heavy tailed entries

We first study the probabilistic properties of the spectral norm of scaled eigenvalues of large dimensional Toeplitz, circulant and symmetric circulant matrices when the input sequence is independent and identically distributed with appropriate heavy tails. When the input sequence is a stationary two sided moving average process of infinite order, we scale the eigenvalues by the spectral density at appropriate ordinates and study the limit for their maximums.
Modular Strategy for the Construction of Radiometalated Antibodies for Positron Emission Tomography Based on Inverse Electron Demand Diels–Alder Click Chemistry

A modular system for the construction of radiometalated antibodies was developed based on the bioorthogonal cycloaddition reaction between 3-(4-benzylamino)-1,2,4,5-tetrazine and the strained dienophile norbornene. The well-characterized, HER2-specific antibody trastuzumab and the positron emitting radioisotopes 64Cu and 89Zr were employed as a model system. The antibody was first covalently coupled to norbornene, and this stock of norbornene-modified antibody was then reacted with tetrazines bearing the chelators 1,4,7,10-tetraazacyclo-dodecane-1,4,7,10-tetraacetic acid (DOTA) or desferrioxamine (DFO) and subsequently radiometalated with 64Cu and 89Zr, respectively. The modification strategy is simple and robust, and the resultant radiometalated constructs were obtained in high specific activity (2.7–5.3 mCi/mg). For a given initial stoichiometric ratio of norbornene to antibody, the 64Cu-DOTA- and 89Zr-DFO-based probes were shown to be nearly identical in terms of stability, the number of chelates per antibody, and immunoreactivity (>93% in all cases). In vivo PET imaging and acute biodistribution experiments revealed significant, specific uptake of the 64Cu- and 89Zr-trastuzumab bioconjugates in HER2-positive BT-474 xenografts, with little background uptake in HER2-negative MDA-MB-468 xenografts or other tissues. This modular system—one in which the divergent point is a single covalently modified antibody stock that can be reacted selectively with various chelators—will allow for both greater versatility and more facile cross-comparisons in the development of antibody-based radiopharmaceuticals.
Mundane or Magical? Discourses on Technology Adoption in Finnish Schools

Information and communication technologies (ICT) have truly entered our everyday life, both work and leisure. This applies especially to the lives of our children: the children of today have been surrounded by ICT from their birth – personal computers, the Internet, mobile phones, video games, and social media have been an integral part of their everyday life from the early childhood. School should be able to adapt to this change, but this seems to be challenging to achieve: schools are lagging behind the recent developments in ICT. We inquire the reasons for these challenges as regards ICT adoption in the Finnish schools from the perspective of the school principals, i.e. the ones expected to lead their schools to utilize ICT in its full potential. This is a nexus analytic inquiry that first examines these principals’ discourses on ICT and change, revealing several different discourses on them both, constructing the objects of talk in various ways. Afterwards, the study identifies influential participants helping or hindering in the process of change as well as broader societal themes or values that act as drivers of or barriers to change, as pictured in the principals’ talk. Implications for theory and practice are discussed.
From insecure to secure employment: changes in work, health, health related behaviours, and sickness absence

Aims: To determine whether change in employment status (from fixed term to permanent employment) is followed by changes in work, health, health related behaviours, and sickness absence. Methods: Prospective cohort study with four year follow up. Data from 4851 (710 male, 4141 female) hospital employees having a fixed term or permanent job contract on entry to the study were collected at baseline and follow up. Results: At baseline, compared to permanent employees, fixed term employees reported lower levels of workload, job security, and job satisfaction. They also reported greater work ability. All fixed term employees had a lower rate of medically certified sickness absence at baseline. Baseline rate ratios for those who remained fixed term were 0.64 (95% CI 0.55 to 0.75), and were 0.50 (95% CI 0.34 to 0.75) for those who later became permanent. Continuous fixed term employment was not associated with changes in the outcome measures. Change from fixed term to permanent employment was followed by an increase in job security, enduring job satisfaction, and increased medically certified sickness absence (compared to permanent workers rate ratio 0.96 (95% CI 0.80 to 1.16)). Other indicators of work, health, and health related behaviours remained unchanged. Conclusion: Receiving a permanent job contract after fixed term employment is associated with favourable changes in job security and job satisfaction. The corresponding increase in sickness absence might be due to a reduction in presenteeism and the wearing off of health related selection.
Observations on nematodes from the Indonesian shortfin eel Anguilla bicolor bicolor McClelland in India, including a revalidation of Heliconema ahiri Karve, 1941 (Physalopteridae)

Two species of parasitic nematodes, Heliconema ahiri Karve, 1941 (Physalopteridae) and Procamallanus (Spirocamallanus) anguillae Moravec et al., 2006 (Camallanidae), were recorded from the Indonesian shortfin eel Anguilla bicolor bicolor Mc-Clelland in the Chalakkudi River and Veli Lake, respectively, both Kerala, India. The former species (H. ahiri), rediscovered from eels in India after 82 years from its original description, has been redescribed and revalidated based on its specific feature (presence of groups of minute denticles in the mouth) distinguishing it from other congeners; its finding in A. b. bicolor represents a new host record. The latter species (P. anguillae) has been recorded in India for the first time. SEM examination of its first-stage larvae from uterus has shown that P. anguillae is another species of Procamallanus whose larvae possess a crown of digit-like processes at the tail tip.
Single-molecule imaging of Bacteroides fragilis AddAB reveals the highly processive translocation of a single motor helicase

The AddAB helicase and nuclease complex is used for repairing double-strand DNA breaks in the many bacteria that do not possess RecBCD. Here, we show that AddAB, from the Gram-negative opportunistic pathogen Bacteroides fragilis, can rescue the ultraviolet sensitivity of an Escherichia coli recBCD mutant and that addAB is required for survival of B. fragilis following DNA damage. Using single-molecule observations we demonstrate that AddAB can translocate along DNA at up to 250 bp per second and can unwind an average of 14 000 bp, with some complexes capable of unwinding 40 000 bp. These results demonstrate the importance of processivity for facilitating encounters with recognition sequences that modify enzyme function during homologous recombination.
Robust Adaptive Fault-Tolerant Control for a Class of Unknown Nonlinear Systems

This paper studies the fault-tolerant tracking control problem for a class of strict-feedback nonlinear systems subjected to actuator faults and external disturbances. The prior knowledge for actuator fault, nonlinearity, and external disturbance is totally unknown, besides the control directions. Based on a backstepping approach, an adaptive fault-tolerant control scheme is developed, without utilizing neural networks. In the control design, a group of new feedback mechanisms are proposed to compensate for the unknown system dynamics and actuator faults. Furthermore, to relax a requirement of the initial system states, a modification technique is designed to adjust the reference signal and virtual control laws for a short time. It is shown that the global closed-loop stability is guaranteed and the tracking performance is achieved. The above result is illustrated via simulations on a one-link manipulator and a ship autopilot.