Miracle-dz/UniFAR-FTUs huggingface dataset:
Risk of Intestinal Malignancy in Patients With Short Bowel Syndrome

Background: Postresection intestinal adaptation is an augmented self-renewal process that might increase the risk of malignant transformation in the intestine. Furthermore, patients with short bowel syndrome (SBS) have other characteristics that might increase this risk. Our aim was to determine the incidence of new intestinal malignancy in SBS patients. Methods: We reviewed the records of 500 adult SBS patients identified from 1982–2013. There were 199 men and 301 women ranging in age from 19–91 years. Follow-up from the time of diagnosis of SBS ranged from 12–484 months. A total of 186 (37%) patients were followed >5 years. Results: The cause of SBS was postoperative in 35% of patients, malignancy/radiation in 19%, mesenteric vascular disease in 17%, Crohn’s disease in 16%, and other in 13%. Twenty-eight (6%) patients received growth stimulatory medications. Fifteen percent of patients had a prior total colectomy. Twenty-eight (6%) patients underwent intestinal transplantation, and 115 (23%) patients had a previous abdominal malignancy, including colorectal cancer in 43 patients. Thirty-six (7%) received radiation therapy. Recurrent colon cancer was found in 2 patients, one at a stoma and the other with lung metastases. New colon cancer was found in 1 patient (0.2%), a 62-year-old woman with long-standing Crohn’s disease. Conclusion: The incidence of colon cancer in this heterogenous group of patients with SBS was similar to that of the normal population. This suggests that the risk of developing a new colon cancer in patients with SBS is not increased.
Changes in extracellular matrix in subcutaneous small resistance arteries of patients with essential hypertension

Abstract Background: In the development of hypertensive microvascular remodeling, a relevant role may be played by changes in extracellular matrix proteins. Aim of this study was the to evaluate some extracellular matrix components within the tunica media of subcutaneous small arteries in 9 normotensive subjects and 12 essential hypertensive patients, submitted to a biopsy of subcutaneous fat from the gluteal or the anterior abdominal region. Patients and Methods: Subcutaneous small resistance arteries were dissected and mounted on an isometric myograph, and the tunica media to internal lumen ratio was measured. In addition, fibronectin, laminin, transforming growth factor-beta-1 (TGF-β1) and emilin-1 contents within the tunica media were evaluated by immunofluorescence and relative immunomorphometrical analysis (immunopositivity % of area). The total collagen content and collagen subtypes within the tunica media were evaluated using both Sirius red staining (under polarized light) and immunofluorescence assay. Results: Normotensive controls had less total and type III collagen in respect with hypertensive patients. Fibronectin and TGF-β1 tunica media content was significantly greater in essential hypertensive patients, compared with normotensive controls, while laminin and emilin-1 tunica media content was lesser in essential hypertensive patients, compared with normotensive controls. A significant correlation was observed between fibronectin tunica media content and media to lumen ratio. Conclusions: Our results indicate that, in small resistance arteries of patients with essential hypertension, a relevant fibrosis may be detected; fibronectin and TGF-β1 tunica media content is increased, while laminin and emilin-1 content is decreased; these changes might be involved in the development of small resistance artery remodeling in humans.
Adherence to Oral Anticancer Medications: Evolving Interprofessional Roles and Pharmacist Workforce Considerations

Interprofessional care is exhibited in outpatient oncology practices where practitioners from a myriad of specialties (e.g., oncology, nursing, pharmacy, health informatics and others) work collectively with patients to enhance therapeutic outcomes and minimize adverse effects. Historically, most ambulatory-based anticancer medication therapies have been administrated in infusion clinics or physician offices. Oral anticancer medications (OAMs) have become increasingly prevalent and preferred by patients for use in residential or other non-clinic settings. Self-administration of OAMs represents a significant shift in the management of cancer care and role responsibilities for patients and clinicians. While patients have a greater sense of empowerment and convenience when taking OAMs, adherence is a greater challenge than with intravenous therapies. This paper proposes use of a qualitative systems evaluation, based on theoretical frameworks for interdisciplinary team collaboration and systems science, to examine the social interactionism involved with the use of intravenous anticancer treatments and OAMs (as treatment technologies) by describing patient, organizational, and social systems considerations in communication, care, control, and context (i.e., Kaplan’s 4Cs). This conceptualization can help the healthcare system prepare for substantial workforce changes in cancer management, including increased utilization of oncology pharmacists.
Two major modes of variability of the East Asian summer monsoon

We study the two primary modes of variability associated with the East Asian summer monsoon, as identified using a multivariate Empirical Orthogonal Function (EOF) analysis. The second mode is shown to be related to changes in intensity of the South Asian High at 100 hPa while, consistent with previous work, the first mode is associated with an index for the shear vorticity of the 850 hPa zonal wind over the monsoon region. We show that a linear, dry dynamical model, when driven by the diabatic heating anomalies associated with each mode, can reproduce many of the anomalous circulation features, especially for the first EOF and in the lower troposphere. The model results indicate the importance of diabatic heating anomalies over the tropical Indian Ocean in the dynamics of both modes, especially EOF‐1, and illustrate the role of local diabatic feedback for intensifying the circulation anomalies; in particular, the subtropical anticyclonic anomalies that are found in the positive phase of both modes, and the circulation anomaly associated with the Meiyu/Changma/Baiu rain band. A running cross‐correlation analysis shows that the second EOF is consistently linked to both the decaying and the onset phase of El Niño/Southern Oscillation (ENSO) events throughout the study period (1958–2001). We attribute the connection in the onset phase to zonal wind anomalies along the Equator in the west Pacific associated with this mode. On the other hand, a link between the first EOF and ENSO is found only in the post‐1979 period. We note also the role of sea‐surface temperature anomalies in the tropical Indian Ocean in the dynamics of EOF‐1, and a link to the variability of the Indian summer monsoon in the case of EOF‐2. Copyright © 2010 Royal Meteorological Society
Email Between Patient and Provider: Assessing the Attitudes and Perspectives of 624 Primary Health Care Patients

Background Email between patients and their health care providers can serve as a continuous and collaborative forum to improve access to care, enhance convenience of communication, reduce administrative costs and missed appointments, and improve satisfaction with the patient-provider relationship. Objective The main objective of this study was to investigate the attitudes of patients aged 16 years and older toward receiving email communication for health-related purposes from an academic inner-city family health team in Southern Ontario. In addition to exploring the proportion of patients with a functioning email address and interest in email communication with their health care provider, we also examined patient-level predictors of interest in email communication. Methods A cross-sectional study was conducted using a self-administered, 1-page survey of attitudes toward electronic communication for health purposes. Participants were recruited from attending patients at the McMaster Family Practice in Hamilton, Ontario, Canada. These patients were aged 16 years and older and were approached consecutively to complete the self-administered survey (N=624). Descriptive analyses were conducted using the Pearson chi-square test to examine correlations between variables. A logistic regression analysis was conducted to determine statistically significant predictors of interest in email communication (yes or no). Results The majority of respondents (73.2%, 457/624) reported that they would be willing to have their health care provider (from the McMaster Family Practice) contact them via email to communicate health-related information. Those respondents who checked their personal email more frequently were less likely to want to engage in this electronic communication. Among respondents who check their email less frequently (fewer than every 3 days), 46% (37/81) preferred to communicate with the McMaster Family Practice via email. Conclusions Online applications, including email, are emerging as a viable avenue for patient communication. With increasing utility of mobile devices in the general population, the proportion of patients interested in email communication with their health care providers may continue to increase. When following best practices and appropriate guidelines, health care providers can use this resource to enhance patient-provider communication in their clinical work, ultimately leading to improved health outcomes and satisfaction with care among their patients.
Intrathecal Trastuzumab Treatment in Patients with Breast Cancer and Leptomeningeal Carcinomatosis

Leptomeningeal carcinomatosis is a fatal manifestation of metastatic breast cancer. Investigation of intrathecal (IT) trastuzumab for leptomeningeal carcinomatosis is currently underway; however, there has been no consensus. We report on two cases of human epidermal growth factor receptor 2 positive (HER2+) breast cancer following IT trastuzumab for leptomeningeal carcinomatosis. The first patient was treated with weekly IT 15 mg methotrexate plus IT 50 mg trastuzumab for 7 months, followed by IT trastuzumab (50 mg > 25 mg) for 18 months. The other patient received IT trastuzumab with systemic chemotherapy (trastuzumab and/or paclitaxel) for 13 months. Good control of leptomeningeal disease was achieved with IT trastuzumab in both patients, with survival durations of 20 and 29 months, respectively. We suggest that IT trastuzumab is a promising treatment for patients with HER2+ breast cancer and leptomeningeal carcinomatosis.
Crosstalk Noise in WDM-Based Optical Networks-on-Chip: A Formal Study and Comparison

Optical networks-on-chip (ONoCs) using wavelength-division multiplexing (WDM) technology have progressively attracted more and more attention for their use in tackling the high-power consumption and low bandwidth issues in growing metallic interconnection networks in multiprocessor systems-on-chip. However, the basic optical devices employed to construct WDM-based ONoCs are imperfect and suffer from inevitable power loss and crosstalk noise. Furthermore, when employing WDM, optical signals of various wavelengths can interfere with each other through different optical switching elements within the network, creating crosstalk noise. As a result, the crosstalk noise in large-scale WDM-based ONoCs accumulates and causes severe performance degradation, restricts the network scalability, and considerably attenuates the signal-to-noise ratio (SNR). In this paper, we systematically study and compare the worst case as well as the average crosstalk noise and SNR in three well-known optical interconnect architectures, mesh-based, folded-torus-based, and fat-tree-based ONoCs using WDM. The analytical models for the worst case and the average crosstalk noise and SNR in the different architectures are presented. Furthermore, the proposed analytical models are integrated into a newly developed crosstalk noise and loss analysis platform (CLAP) to analyze the crosstalk noise and SNR in WDM-based ONoCs of any network size using an arbitrary optical router. Utilizing CLAP, we compare the worst case as well as the average crosstalk noise and SNR in different WDM-based ONoC architectures. Furthermore, we indicate how the SNR changes in respect to variations in the number of optical wavelengths in use, the free-spectral range, and the microresonators Q factor. The analyses' results demonstrate that the crosstalk noise is of critical concern to WDM-based ONoCs: in the worst case, the crosstalk noise power exceeds the signal power in all three WDM-based ONoC architectures, even when the number of processor cores is small, e.g., 64.
Facilitating Change

The authors highlight a community’s response to women’s use of force, detail aspects of intervention strategies, and introduce a conceptual model representing the women’s change process. In doing so, they encourage community partnerships, continued intervention innovation, and further research. Their observations suggest an intervention philosophy and approach that women have described as one of personal “renewal. ” The community’s experiences are notable in light of national efforts to effectively meet the needs of female survivors of intimate partner violence who have used force.
Molecular structure and physical properties of E-beam crosslinked low-density polyethylene for wire and cable insulation applications

Crosslinking of homemade low-density polyethylene (LDPE) was performed by electron-beam (EB) irradiation. The gel content of the EB-exposed LDPE was determined by the solvent-extraction method. The degree of crosslinking was also evaluated by a hot set measuring test. The results obtained from both the gel–sol and the hot set methods showed that the degree of crosslinking was dependent on the deposited energy in LDPE samples. Increasing the absorbed dose increased the degree of network formation. The LDPE with higher molecular weight yielded higher efficiency of crosslinking at the same irradiation dose. The effect of irradiation dose on the molecular weight between crosslinks (Mc), glass-transition temperature, and free volume were calculated. Mechanical test results showed that the tensile strength of the samples increased with increase in the irradiation dose up to 150 kGy and then slightly decreased with further increasing the deposited energy. The elongation at break decreased with increasing the absorbed dose. The results obtained from differential scanning calorimetry exhibited a small reduction in the melting point and the degree of crystallinity of the EB-exposed LDPE samples compared to those of the untreated samples. The effect of crosslinking on the electrical properties of the irradiated samples was insignificant. The dielectric constant of the treated samples remained nearly constant within the irradiation dose range, although the dissipation factor increased slightly with increasing the absorbed dose. The results obtained from characterizing the EB-induced crosslinking of homemade polyethylene, including LH0030 and LH0075, showed the higher molecular weight polyethylene (LH0030) as a preferred option for wire and cable insulation. © 2002 Wiley Periodicals, Inc. J Appl Polym Sci 86: 1959–1969, 2002
Protein Acetylation and Butyrylation Regulate the Phenotype and Metabolic Shifts of the Endospore-forming Clostridium acetobutylicum*

Clostridium acetobutylicum is a strict anaerobic, endospore-forming bacterium, which is used for the production of the high energy biofuel butanol in metabolic engineering. The life cycle of C. acetobutylicum can be divided into two phases, with acetic and butyric acids being produced in the exponential phase (acidogenesis) and butanol formed in the stationary phase (solventogenesis). During the transitional phase from acidogenesis to solventogenesis and latter stationary phase, concentration peaks of the metabolic intermediates butyryl phosphate and acetyl phosphate are observed. As an acyl group donor, acyl-phosphate chemically acylates protein substrates. However, the regulatory mechanism of lysine acetylation and butyrylation involved in the phenotype and solventogenesis of C. acetobutylicum remains unknown. In our study, we conducted quantitative analysis of protein acetylome and butyrylome to explore the dynamic change of lysine acetylation and butyrylation in the exponential phase, transitional phase, and stationary phase of C. acetobutylicum. Total 458 lysine acetylation sites and 1078 lysine butyrylation sites were identified in 254 and 373 substrates, respectively. Bioinformatics analysis uncovered the similarities and differences between the two acylation modifications in C. acetobutylicum. Mutation analysis of butyrate kinase and the central transcriptional factor Spo0A was performed to characterize the unique role of lysine butyrylation in the metabolic pathway and sporulation process of C. acetobutylicum. Moreover, quantitative proteomic assays were performed to reveal the relationship between protein features (e.g. gene expression level and lysine acylation level) and metabolites in the three growth stages. This study expanded our knowledge of lysine acetylation and butyrylation in Clostridia and constituted a resource for functional studies on lysine acylation in bacteria.
RIG-I Resists Hypoxia-Induced Immunosuppression and Dedifferentiation

Solid tumors are generally hypoxic. RIG-I, but not IFNα, still functioned under hypoxia. Activating RIG-I and using vitamin C to scavenge free radicals in a melanoma model augmented NK and CD8+ T cell antitumor functions and prolonged survival. A hypoxic tumor microenvironment is linked to poor prognosis. It promotes tumor cell dedifferentiation and metastasis and desensitizes tumor cells to type-I IFN, chemotherapy, and irradiation. The cytoplasmic immunoreceptor retinoic acid-inducible gene-I (RIG-I) is ubiquitously expressed in tumor cells and upon activation by 5′-triphosphate RNA (3pRNA) drives the induction of type I IFN and immunogenic cell death. Here, we analyzed the impact of hypoxia on the expression of RIG-I in various human and murine tumor and nonmalignant cell types and further investigated its function in hypoxic murine melanoma. 3pRNA-inducible RIG-I–expression was reduced in hypoxic melanoma cells compared with normoxic controls, a phenomenon that depended on the hypoxia-associated transcription factor HIF1α. Still, RIG-I functionality was conserved in hypoxic melanoma cells, whereas responsiveness to recombinant type-I IFN was abolished, due to hypoxia-induced loss of type I IFN receptor expression. Likewise, RIG-I activation in hypoxic melanoma cells, but not exposure to recombinant IFNα, provoked melanocyte antigen-specific CD8+ T-cell and NK-cell attack. Scavenging of hypoxia-induced reactive oxygen species by vitamin C restored the inducible expression of RIG-I under hypoxia in vitro, boosted in vitro anti-melanoma NK- and CD8+ T-cell attack, and augmented 3pRNA antitumor efficacy in vivo. These results demonstrate that RIG-I remains operational under hypoxia and that RIG-I function is largely insensitive to lower cell surface expression of the IFNα receptor. RIG-I function could be fortified under hypoxia by the combined use of 3pRNA with antioxidants. Cancer Immunol Res; 5(6); 455–67. ©2017 AACR.
Trust-related Effects of Expertise and Similarity Cues in Human-Generated Recommendations

A user’s trust in recommendations plays a central role in the acceptance or rejection of a recommendation. One factor that inﬂuences trust is the source of the recommendations. In this paper we describe an empirical study that investigates the trust-related inﬂuence of social presence arising in two scenarios: human-generated recommendations and automated recommending. We further compare visual cues indicating the expertise of a human recommendation source and its similarity with the target user, and evaluate their inﬂuence on trust. Our analysis indicates that even subtle visual cues can signal expertise and similarity effectively, thus inﬂuencing a user’s trust in recommendations. These ﬁndings suggest that automated recommender systems could beneﬁt from the inclusion of social components—especially when conveying characteristics of the recommendation source. Thus, more informative and persuasive recommendation interfaces may be designed using such a mixed approach.
Breast Cancer Risk and Progressive Histology in Serial Benign Biopsies

Background: More than 1 million women per year in the United States with benign breast biopsies are known to be at elevated risk for breast cancer (BC), with risk stratified on histologic categories of epithelial proliferation. Here we assessed women who had serial benign biopsies over time and how changes in the histologic classification affected BC risk. Methods: In the Mayo Clinic Benign Breast Disease Cohort of 13 466 women, 1414 women had multiple metachronous benign biopsies (10.5%). Both initial and subsequent biopsies were assessed histologically. BC risk for clinical and prognostic factors was assessed using subdistribution models to account for competing risks, and logistic regression/Wilcoxon/chi-square tests to assess covariates. All statistical tests were two-sided. Results: Breast cancer risk for women with serial biopsies, stratified by histologic category in the later biopsies, was similar to women with a single biopsy. We found that changes in histological category between initial and subsequent biopsy statistically significantly impacted BC risk. Women with nonproliferative initial findings and subsequent proliferative findings had an increased risk (hazard ratio [HR] = 1.77, 95% confidence interval [CI] = 1.06 to 2.94, P = .03) compared with no change. Among women with proliferative disease without atypia at initial biopsy, risk decreased if later biopsy regressed to nonproliferative (HR = 0.49, 95% CI = 0.25 to 0.98) and increased if later biopsy showed progression to atypical hyperplasia (HR = 1.49, 95% CI = 0.73 to 3.05) compared with no change (P = .04). Conclusions: We found that breast cancer risk increases in women with progressive epithelial proliferation over time and decreases in women whose biopsies show less proliferation. This finding has important implications for effective clinical management of the 100 000 women per year who have multiple benign breast biopsies.
Data-Based Line Trip Fault Prediction in Power Systems Using LSTM Networks and SVM

Power system faults are significant problems in power transmission and distribution. Methods based on relay protection actions and electrical component actions have been put forward in recent years. However, they have deficiencies dealing with power system fault. In this paper, a method for data-based line trip fault prediction in power systems using long short-term memory (LSTM) networks and support vector machine (SVM) is proposed. The temporal features of multisourced data are captured with LSTM networks, which perform well in extracting the features of time series for a long-time span. The strong learning and mining ability of LSTM networks is suitable for a large quantity of time series in power transmission and distribution. SVM, with a strong generalization ability and robustness, is introduced for classification to get the final prediction results. Considering the overfitting problem in fault prediction, layer of dropout and batch normalization are added into the network. The complete network architecture is shown in this paper in detail. The parameters are adjusted to fit the specific situation of the actual power system. The data for experiments are obtained from the Wanjiang substation in the China Southern Power Grid. The real experiments prove the proposed method’s improvements compared with current data mining methods. Concrete analyses of results are elaborated in this paper. A discussion of practical applications is presented to demonstrate the feasibility in real scenarios.