Miracle-dz/UniFAR-FTUs huggingface dataset:
Why Not Let High Ability Students Start School in January? The Curriculum Compacting Study. Research Monograph 93106.

During the 1990-1991 academic year, The University of Connecticut site of The National Research Center on the Gifted and Talented conducted a study to examine the effects of a curriculum modification technique entitled curriculum compacting. This technique is designed to modify the regular curriculum to meet the needs of gifted and talented students in the regular classroom. The study was designed to investigate the types and amount of curriculum content that could be eliminated for high ability students by teachers who received various levels of staff development. It also examined what would happen to students' achievement, content area preferences, and attitudes toward learning if curriculum compacting was implemented. To participate in this study, districts had to meet and accept the following criteria: (1) no previous training in curriculum compacting, and (2) random assignment to treatment groups. Efforts were made to recruit districts throughout the country with elementary student populations that included economically disadvantaged and limited English proficient students. Teachers in 27 school districts were randomly assigned by district to four groups, three treatment groups that received increasing levels of staff development or a control group. After receiving staff development services, teachers in each of the treatment groups implemented curriculum compacting for one or two high ability students in their classrooms. The control group teachers identified one or two high ability students and continued normal teaching practices without implementing curriculum compacting. A battery of pre and post achievement tests (out-of-level Iowa Tests of Basic Skills), Content Area Preference Scales, and a questionnaire regarding attitude toward learning were administered to identified students in the fall and at the completion of the school year. The results of this study indicate that the compacting process can be implemented in a wide variety of settings with positive effects for both students and teachers. In addition, the results expand previous knowledge about effective and efficient methods for training teachers to make appropriate and challenging curricular modifications for gifted and talented students in regular classrooms.
AN INTEGRAL UNIVALENT OPERATOR DEFINED BY GENERALIZED Al-OBOUDI DIFFERENTIAL OPERATOR ON THE CLASSES

In [4], Breaz and Breaz gave the univalence conditions of the integral operator Fα,n of the analytic functions belonging to the classes T2, T2,μ and S(p). The purpose of this paper is to generalize the integral operator Fα,n by means of the generalized Al-Oboudi differential operator and investigate univalence conditions of this generalized integral operator considering the classes Tj , Tj,μ and Sj(p) (j = 2, 3, . . .). AMS Mathematics Subject Classification (2000): 30C45
Cardiovascular Lifetime Risk Predicts Incidence of Coronary Calcification in Individuals With Low Short‐Term Risk: The Dallas Heart Study

Background The absence of coronary artery calcium (CAC) in middle age is associated with very low short‐term risk for coronary events. However, the long‐term implications of a CAC score of 0 are uncertain, particularly among individuals with high cardiovascular lifetime risk. We sought to characterize the association between predicted lifetime risk and incident CAC among individuals with low short‐term risk. Methods and Results We included 754 Dallas Heart Study participants with serial CAC scans (6.9 years apart) and both low short‐term risk and baseline CAC=0. Lifetime risk for cardiovascular disease was estimated according to risk factor burden. Among this group, 365 individuals (48.4%) were at low lifetime risk and 389 (51.6%) at high lifetime risk. High lifetime risk was associated with higher annualized CAC incidence (4.2% versus 2.7%; P < 0.001). Similarly, mean follow‐up CAC scores were higher among participants with high lifetime risk (7.8 versus 2.4 Agatston units). After adjustment for age, sex, and race, high lifetime risk remained independently associated with incident CAC (OR 1.60; 95% CI 1.12 to 2.27; P=0.01). When assessing risk factor burden at the follow‐up visit, 66.7% of CAC incidence observed in the low lifetime risk group occurred among individuals reclassified to a higher short‐ or long‐term risk category. Conclusion Among individuals with low short‐term risk and CAC scores of 0, high lifetime risk is associated with a higher incidence of CAC. These findings highlight the importance of lifetime risk even among individuals with very low short‐term risk.
miR-204-5p promotes the adipogenic differentiation of human adipose-derived mesenchymal stem cells by modulating DVL3 expression and suppressing Wnt/β-catenin signaling

MicroRNAs (miRNAs or miRs) play an important regulatory role during adipogenesis, and have been studied extensively in this regard. Specifically, the switch between the differentiation of mesenchymal stem cells (MSCs) towards adipogenic vs. osteogenic lineages is regulated by miR-204 which controls the expression of Runx2. However, the association between miR-204-5p and the Wnt/β-catenin signaling pathway during adipogenesis has not yet been clarified. In the present study, we demonstrate that miR-204-5p regulates the in vitro adipogenesis of human adipose-derived mesenchymal stem cells (hADSCs). The level of miR-204-5p was shown to be gradually upregulated during adipocytic differentiation, together with the mRNA expression of the critical adipogenic transcription factors, cytidine-cytidine-adenosine-adenosine-thymidine (CCAAT) enhancer binding protein α (C/EBPα) and peroxisome proliferator-activated receptor γ (PPARγ), and the mature adipogenic marker, fatty acid binding protein 4 (FABP4). We further demonstrate that while the overexpression of miR-204-5p promotes adipogenesis, its knockdown causes the inhibition of this process. We then used bioinformatics tools and luciferase reporter assay to establish that dishevelled segment polarity protein 3 (DVL3), a key regulator of the Wnt/β-catenin signaling pathway, is a direct target of miR-204-5p. In addition, the overexpression of DVL3 led to an increase in β-catenin and cyclin D1 (CCND1) expression and, by contrast, the knockdown of DVL3 led to a decrease in the expression of β-catenin and CCND1. The knockdown of DVL3 significantly promoted adipogenesis. Finally, we demonstrated that the overexpression of miR-204-5p induced the downregulation of β-catenin and the canonical Wnt target gene, CCND1, in mature adipoctyes, while its knockdown led to their upregulation. Taken together, our data suggest that miR-204-5p regulates adipogenesis by controlling DVL3 expression and subsequently inhibiting the activation of the Wnt/β-catenin signaling pathway.
Non-programmed computation

Computation is symbol manipulation. Who could argue with that? A wide variety of such symbol manipulation strategies are available, but they virtually all spring from a single notion: that of reproducing our conscious computational procedures within a physical device. The unstated assumption in the answer to the opening question is that the symbol structures are essentially the same as we would use, and that they are manipulated in essentially the same ways at the conceptual level. The clear benefits that spring from this translation of conscious computational procedures from the slow and error-prone human brain to the very fast and very accurate physical computer are obvious to all. The wide variety of particular manifestations of this notion, conventional computing, are all keyed to the process of programming, i.e. constructing a complex formula, a program, that will become the 'mechanical' simulation of the conscious computational process when appropriately instantiated in a computer. From this viewpoint conventional computing is programmed computation. There is another paradigm for computation, a radically different way to compute; it is computing without programs, or non-programmed computation (NPC). As a new paradigm should, it changes the way we look at computational problems • "It gives us a new framework for thinking about problems in the future. It changes our priorities and values, changes our ideas about what to pay attention to and what to consider important. " ([6], p. 38). As Dijkstra observes: "Coming to grips with a radical novelty amounts to creating and learning a new foreign language that cannot be translated into one's own mother tongue • " ([2], p. 1398) We will use the term PROGRAMS to name the implementations of an NPC process • Here, in the context of a specific NPC technique, a more meaningful name will be proposed. Indeed, they exhibit a general absence of infrastructure in terms of the normal conceptualizations of a computational task. Thus PROGRAMS cannot be constructed in the conventional manner, that is, a deliberate and systematic decomposition of the computational task into readily comprehensible computational elements, followed by a similarly systematic synthesis of the program from these 'atomic' computational chunks, such as primitive functions or objects.
Vesicle-associated Membrane Protein 3 (VAMP3) Mediates Constitutive Trafficking of the Renal Co-transporter NKCC2 in Thick Ascending Limbs

Renal cells of the thick ascending limb (TAL) reabsorb NaCl via the apical Na+/K+/2Cl− co-transporter NKCC2. Trafficking of NKCC2 to the apical surface regulates NKCC2-mediated NaCl absorption and blood pressure. The molecular mechanisms by which NKCC2 reaches the apical surface and their role in renal function and maintenance of blood pressure are poorly characterized. Here we report that NKCC2 interacts with the vesicle fusion protein VAMP3, and they co-localize at the TAL apical surface. We observed that silencing VAMP3 in vivo blocks constitutive NKCC2 exocytic delivery, decreasing the amount of NKCC2 at the TAL apical surface. VAMP3 is not required for cAMP-stimulated NKCC2 exocytic delivery. Additionally, genetic deletion of VAMP3 in mice decreased total expression of NKCC2 in the TAL and lowered blood pressure. Consistent with these results, urinary excretion of water and electrolytes was higher in VAMP3 knock-out mice, which produced more diluted urine. We conclude that VAMP3 interacts with NKCC2 and mediates its constitutive exocytic delivery to the apical surface. Additionally, VAMP3 is required for normal NKCC2 expression, renal function, and blood pressure.
Variability in the Use of Misdemeanor Arrests by Police Agencies From 1990 to 2013: An Application of Group-Based Trajectory Modeling

Arrest for minor offenses has become one tool that some police departments employ to fight crime and disorder in their jurisdictions. Dubbed by some as “broken windows” or “zero tolerance” policing, a few police agencies in the 1990s and 2000s notably and significantly increased their use of arrest for such misdemeanors, such as New York City and Baltimore. But was this the case for other law enforcement agencies in the United States? Our analysis is the first to examine long-term trends in the use of misdemeanor arrests in a sample of U.S. law enforcement agencies using group-based trajectory modeling. Results show that police agencies have distinct longitudinal patterns of use of arrests for minor crimes from 1990 to 2013; some agencies significantly increased their use of arrests for minor crimes while others did not. Further analysis of possible explanations for agency membership in any given longitudinal trajectory found that agencies with similar patterns in their use of misdemeanor arrests were not similar on demographic or crime characteristics. This finding suggests that the decision to increase the use of arrest for minor offenses may have been a policy choice by agencies influenced by factors not detected here.
Laura and Petrarch: An Intriguing Case of Cyclical Love Dynamics

Three ordinary dierential equations are proposed to model the dynamics of love between Petrarch, a celebrated Italian poet of the 14th century, and Laura, a beautiful but married lady. The equations are nonlinear but can be studied through the singular perturbation approach if the inspiration of the poet is assumed to have very slow dynamics. In such a case, explicit conditions are found in the appeals of Laura and Petrarch and in their behavioral parameters that guarantee the existence of a globally stable slow-fast limit cycle. These conditions are consistent with the relatively clear portrait of the two personalities one gets while reading the poems addressed to Laura. On the basis of the scarce and only qualitative information available, the calibration of the parameters is also performed; the result is that the calibrated model shows that the poet's emotions followed for about 20 years a quite regular cyclical pattern ranging from the extremes of ecstasy to despair. All these ndings agree with the recent results of Frederic Jones, who, through a detailed stylistic and linguistic analysis of the poems inspired by Laura, has discovered Petrarch's emotional cycle in a fully independent way.
The Impact of Impervious Surface on Water Quality and Its Threshold in Korea

The change in the impervious-pervious balance has significantly altered the stream water quality, and thus the threshold of the impervious surface area in the watershed has been an active research topic for many years. The objective of this study is to verify the correlation between impervious surfaces and water quality and to determine the threshold of the percentage of the impervious surface area (PISA) for diagnosing the severity of future stream water quality problems in the watershed as well as regulating the PISA in Korea. Statistical results indicated that the PISA is a suitable indicator of water quality at the watershed scale and can illustrate the water quality problems caused by the impervious surface. In addition, the results from this study suggest that controlling the PISA within about 10% in watersheds is a fundamental strategy to mitigate the degradation of water quality.
Cloning of the Quail PIWI Gene and Characterization of PIWI Binding to Small RNAs

The PIWI protein regulates gene expression at the epigenetic and post-transcriptional level with a variety of endogenous small non-coding RNAs. In poultry, the biological function of the PIWI protein and PIWI binding to small RNAs had not been determined. The present study cloned and analyzed the sequences of the PIWIL1 protein. We also characterized PIWIL1 binding to small RNAs from adult quail testis, where the PIWIL1 protein is specifically expressed. Small RNAs showed a strong peak at 24–27 nt in the testicular RNA library, mapped primarily to repeat sequences and were similar to rasiRNAs. MicroRNAs (miRNAs) were abundant in the ovarian RNA library at a peak of 22 nt.
Topotecan: An evolving option in the treatment of relapsed small cell lung cancer

The topoisomerase I inhibitor topotecan is the only single-agent therapy approved for the treatment of recurrent small cell lung cancer (SCLC). Many patients with recurrent SCLC may be predisposed to treatment-related adverse events because of the presence of comorbidities such as advanced age, renal impairment, or extensive prior therapy. In this setting, disease stabilization is considered a treatment benefit, and quality-of-life effects and toxicity profiles of treatments should be considered. The approved regimen of topotecan 1.5 mg/m2 on days 1 to 5 of a 21-day cycle is active and has generally mild nonhematologic toxicity and a well-established hematologic toxicity profile characterized by reversible, manageable, and noncumulative neutropenia. Alternative dosing and treatment schedules may lower the incidence of hematologic toxicities while maintaining antitumor efficacy in this patient population. Therefore, topotecan may provide physicians with an effective and versatile therapeutic option for the treatment of patients with relapsed SCLC.
Examining Differences in affect displayed during preschoolers’ non-medical pretend play and medical pretend play

ABSTRACT Medical play is a play that involves medical themes and is used to familiarize children with the medical world. Few studies have examined medical play outside of the hospital or the affect displayed during medical play. This study examined differences in affect in non-hospitalized children participating in medical pretend play as compared to non-medical pretend play. Thirty-seven children, 3–4 years old, engaged in medical pretend play and non-medical pretend play. Play sessions were videorecorded and coded to examine the affect displayed in each session. Children also rated their feelings during the play sessions. The children displayed less affect, exhibited less fantasy and comfort, and engaged in play less during medical pretend play than during non-medical pretend play. In addition, children reported more negative feelings about medical pretend play. Such findings begin to help adults working with children understand what to expect during medical pretend play.
Gravitational quasinormal modes for anti-de Sitter black holes

The quasinormal mode spectra for gravitational perturbations of black holes in four-dimensional de Sitter and anti-de Sitter space are investigated. The de Sitter case lends itself to approximation by a Poshcl–Teller potential. The anti-de Sitter case is relevant to the AdS-CFT correspondence in superstring theory. The ADS-CFT correspondence suggests a preferred set of boundary conditions.
Higher-Order Improvements of the Parametric Bootstrap for Markov Processes

This paper provides bounds on the errors in coverage probabilities of maximum likelihood-based, percentile-t, parametric bootstrap confidence intervals for Markov time series processes. These bounds show that the parametric bootstrap for Markov time series provides higher-order improvements (over confidence intervals based on first order asymptotics) that are comparable to those obtained by the parametric and nonparametric bootstrap for iid data and are better than those obtained by the block bootstrap for time series. Additional results are given for Wald-based confidence regions. The paper also shows that k-step parametric bootstrap confidence intervals achieve the same higher-order improvements as the standard parametric bootstrap for Markov processes. The k-step bootstrap confidence intervals are computationally attractive. They circumvent the need to compute a nonlinear optimization for each simulated bootstrap sample. The latter is necessary to implement the standard parametric bootstrap when the maximum likelihood estimator solves a nonlinear optimization problem.
Regular Education Teachers’ Attitudes towards Inclusion in Oman

The objectives of the study were to investigate regular education teachers’ attitudes towards inclusion and their educational setting preferences for teaching students with disabilities. In addition, the impact of teachers’ gender and teaching experience on the attitudes towards inclusion were examined. Seven hundred three Omani regular education teachers participated in this study. The findings suggest that the Omani regular education teachers held neutral behavior, cognitive, and affective attitudes towards inclusion; and a small minority of teachers believed that full inclusion in regular education classrooms or resource rooms were the best educational settings for educating the students with disabilities in comparison with other educational settings. Finally, the results indicated that there were significant relationships between teachers’ gender, teaching experience, and educational settings preference for educating students with disabilities and teachers' attitudes towards inclusion.
Sexual Orientation Wage Gaps across Local Labour Market Contexts: Evidence from Canada

Mounting evidence suggests that sexual orientation matters in the labour market. Research in Canada points to a wage hierarchy not only by gender, but also by sexual orientation, with heterosexual men out-earning gay men, lesbians, and heterosexual women. While previous work has considered how human capital characteristics, occupation and industry of employment, and family status factor into the creation of these earnings disparities, little research has examined how residential concentration in large metropolitan areas factors into the creation of sexual orientation pay gaps.Drawing on the 2006 Census of Canada, this study investigates how sexual orientation wage gaps vary across geographic areas in Canada, documenting earnings disparities across the metropolitan/non-metropolitan divide as well as for Toronto, Montreal and Vancouver. We also evaluate whether the mechanisms contributing to wage gaps diverge across these contexts, focusing on how pay gaps differ across occupations, points in the earnings distribution, and sectors of employment.Our results show that pay gaps are highest in non-metropolitan Canada. The underlying components of wage gaps fluctuate across Canada, especially for gay men. Sexual orientation earnings penalties are reduced in public sector employment, even where private sector wage gaps are highest. These results suggest that local social and labour market contexts are associated with the earnings outcomes of sexual minorities.
Cost over Progress Based Energy Efficient Routing over Virtual Coordinates in Wireless Sensor Networks

We propose an energy efficient routing protocol, VCost, for sensor networks. We assume that nodes are unaware of their geographic location thus, VCost assigns virtual coordinates to nodes as follows. Based on the node hop count distances from a set of landmarks, our method computes a distance metric to obtain the node's virtual coordinates. VCost, then uses these coordinates to route packets from node u to node v, in its neighborhood, such that the ratio of the cost to send a message to v to the progress in the routing task towards the destination is minimized. Compared to existing algorithms that use virtual locations, our simulation shows that VCost improves significantly energy consumption and preserves the small percentage of successful routings.
Exploiting Community Emotion for Microblog Event Detection

Microblog has become a major platform for information about real-world events. Automatically discovering realworld events from microblog has attracted the attention of many researchers. However, most of existing work ignore the importance of emotion information for event detection. We argue that people’s emotional reactions immediately reflect the occurringofreal-worldeventsand shouldbeimportant for event detection. In this study, we focus on the problem of communityrelated event detection by community emotions. To address the problem, we propose a novel framework which include the following three key components: microblog emotion classification, community emotion aggregation and community emotion burst detection. We evaluate our approach on real microblog data sets. Experimental results demonstrate the effectiveness of the proposed framework.
Translanguaging in Schools: Subiendo y Bajando, Bajando y Subiendo as Afterword

ABSTRACT Translanguaging pedagogies are considered here as mechanisms that work against the normalizing ideology of monolingual and monoglossic school language. In so doing, we consider how this restrictive view of school language and of language education policy has served to minoritize bilingual students and act as an instrument to exert “coloniality of power. ” We start by describing the translanguaging theory that supports the translanguaging pedagogies to educate bilingual minoritized youth that this special issue highlights. We then focus on how translanguaging pedagogies liberate the students’ multilingualism and heteroglossic practices. Keeping with the title here of “subiendo y bajando, bajando y subiendo,” we consider the restrictions that are imposed by rigid language policies, as teachers who enact translanguaging pedagogies negotiate them. We also reflect on the potential and contestations of translanguaging in classrooms, both bilingual and not. We end by thinking about the work that still remains to be done.