Miracle-dz/UniFAR-FTUs huggingface dataset:
Validity and Reliability of the Dutch Adaptation of the Psoriatic Arthritis Quality of Life (PsAQoL) Questionnaire

Objective The Psoriatic Arthritis Quality of Life (PsAQoL) questionnaire is a disease- specific instrument developed to measure quality of life (QoL) in patients with psoriatic arthritis (PsA). The aim of this study was to translate the measure into Dutch and to determine its psychometric properties. Method Translation of the original English PsAQoL into Dutch was performed by bilingual and lay panel. Ten field-test interviews with PsA patients were performed to assess face and content validity. In total, 211 PsA patients were included in a test-retest postal survey to investigate the reliability and construct validity of the Dutch adaptation of the PsAQoL. The PsAQoL, Health Assessment Questionnaire (HAQ) and Skindex-17 were administered on two different occasions approximately two weeks apart. Results The Dutch version of the PsAQoL was found to be relevant, understandable and easy to complete in only a few minutes. It correlated as expected with the HAQ (Spearman’s ρ = 0.72) and the 2 subscales of the Skindex-17 (ρ = 0.40 for the psychosocial and ρ = 0.46 for the symptom scale). Furthermore, the measure had good internal consistency (Cronbach’s α = 0.92) and test-retest reliability (ρ = 0.89). The PsAQoL was able to define groups of patients based on self-reported general health status, self-reported severity of PsA and flare of arthritis. Duration of PsA did not influence PsAQoL scores. Conclusions The Dutch version of the PsAQoL is a valid and reliable questionnaire suitable for use in clinical or research settings to asses PsA-specific QoL.
Stock Prediction Using Event-Based Sentiment Analysis

We propose a novel approach to label social media text using significant stock market events (big losses or gains). Since stock events are easily quantifiable using returns from indices or individual stocks, they provide meaningful and automated labels. We extract significant stock movements and collect appropriate pre, post and contemporaneous text from social media sources (for example, tweets from twitter). Subsequently, we assign the respective label (positive or negative) for each tweet. We train a model on this collected set and make predictions for labels of future tweets. We aggregate the net sentiment per each day (amongst other metrics) and show that it holds significant predictive power for subsequent stock market movement. We create successful trading strategies based on this system and find significant returns over other baseline methods.
Off-Line Processing: Reciprocal Interactions between Declarative and Procedural Memories

The acquisition of declarative (i.e., facts) and procedural (i.e., skills) memories may be supported by independent systems. This same organization may exist, after memory acquisition, when memories are processed off-line during consolidation. Alternatively, memory consolidation may be supported by interactive systems. This latter interactive organization predicts interference between declarative and procedural memories. Here, we show that procedural consolidation, expressed as an off-line motor skill improvement, can be blocked by declarative learning over wake, but not over a night of sleep. The extent of the blockade on procedural consolidation was correlated to participants' declarative word recall. Similarly, in another experiment, the reciprocal relationship was found: declarative consolidation was blocked by procedural learning over wake, but not over a night of sleep. The decrease in declarative recall was correlated to participants' procedural learning. These results challenge the concept of fixed independent memory systems; instead, they suggest a dynamic relationship, modulated by when consolidation takes place, allowing at times for a reciprocal interaction between memory systems.
Tree crown delineation from high resolution airborne LiDAR based on densities of high points

Tree detection and tree crown delineation from Airborne LiDAR has been focusing mostly on utilizing the canopy height model (CHM). This paper presents a method for individual tree crown delineation based on densities of high points (DHP) from the high resolution Airborne LiDAR. The DHP method relies on the fact that the density of received laser pulses above a certain height is high at the centre of a tree crown and decreases towards the edge of the crown. In this study, the performance of this method is compared to the CHM approach. The results demonstrate that tree delineation based on DHP is at least comparable to the CHM approach. The DHP based approach performs better compared to the CHM especially for trees with almost flat-top crown shape. However, post-processing on tree crown segments is still necessary to improve the overall accuracy of tree detection and tree crown delineation.
Patterns of HIV infection among native and refugee Afghans

The current study was conducted to explore the origins of the HIV epidemics among the Afghan refugees in Pakistan and the native Afghans in Afghanistan. Phylogenetic analysis of HIV gag gene from 40 samples showed diverse HIV variants, originating from a number of countries. Intermixing of diverse HIV variants among Afghans may give rise to seeding of infections with rare HIV strains which may pose serious challenges for the treatment and control of infection.
The relationship between employee motivation and psychological health at work: A chicken-and-egg situation?

ABSTRACT Although employee motivation and psychological health at work have been found to be related, it remains unclear whether motivation precedes psychological health or vice versa, and to which extent different manifestations of mental health relate to different forms of motivation at work. Using the self-determination theory and the bidimensional theory of psychological health, this complete panel design study tested the directionality of the relationship between motivation at work and psychological health at work, with a dedicated focus on the specific predictive patterns observed between 4 types of motivation at work and positive and negative indicators of psychological health at work. Eight hundred and five Canadian workers completed questionnaires at 2 times, separated by a 6-month interval. Structural equation modelling analyses indicated that only identified regulation and psychological well-being at work have a fully reciprocal relationship. Only psychological well-being at work was positively associated with the 3 most self-determined types of motivation at work 6 months later, and only identified regulation predicted psychological health at work after 6 months. External regulation was unrelated to all indicators of psychological health at work over time. By integrating 2 theoretical frameworks, this study clarified the relationships between psychological health at work and motivation at work over time.
Speaking and Being Heard: How Nonprofit Advocacy Organizations Gain Attention on Social Media

The social media era ushers in an increasingly “noisy” information environment that renders it more difficult for nonprofit advocacy organizations to make their voices heard. How then can an organization gain attention on social media? We address this question by building and testing a model of the effectiveness of the Twitter use of advocacy organizations. Using number of retweets and number of favorites as proxies of attention, we test our hypotheses with a 12-month panel dataset that collapses by month and organization the 219,915 tweets sent by 145 organizations in 2013. We find that attention is strongly associated with the size of an organization’s network, its frequency of speech, and the number of conversations it joins. We also find a seemingly contradictory relationship between different measures of attention and an organization’s targeting and connecting strategy.
Theoretical and Applicable Approaches in Anxiety Disorders in Children

:هدیکچ :هنیمز ناور عبانم و تلااقم هب هعجارم اب ،يرورم شهوژپ نیا رد دروـم رد يریگ هجیتن و يدنب عمج هب اهنآ شاکنک و هعلاطم و عوضوم اب طبترم یتخانش تخا . تسا هدش مادقا هلخادم ياه شور و اه للاتخا نیا ندمآ دوجو هب للع ،ناکدوک رد یبارطضا ياه للا هجیتن :يریگ هتشاد هژیو هجوت نآ هب نارگ نامرد زا يرایسب هک دنتسه یکدوک نارود تلالاتخا نیرت عیاش زا یبارطضا ياه للاتخا رد هلخادم يارب . دنا یتخانش هیرظن ود اه للاتخا نیا هویش . دنتسه طابترا نیا رد حرطم هویش ود يرلدآ هیرظن و يراتفر یتخانـش ي اـب هـلباقم يارـب ار ییاـهدربهار هـک يراـتفر هویش هب هک رظن نیا زا يرلدآ هیرظن و ینامرد ي هبنج رتشیب دهد یم هیارا یبارطضا ياه للاتخا یـم نیدلاو يزاس وگلا عون و يرورپدنزرف ياه رتـشیب ،دزادرـپ نج . دراد هناریگشیپ ي هب هژاو ياه يدیلک : یتخانش نامرد ،یبارطضا ياه للاتخا يرلدآ هیرظن ،يراتفر
Attitudes and child abuse reporting behaviours among Hong Kong GPs.

BACKGROUND GPs are often the first contact for injured children and hence play a crucial role in early identification and intervention of child abuse cases in the community. OBJECTIVES To investigate Hong Kong GPs' attitudes and behaviours towards child abuse reporting and their opinions on the introduction of a mandatory reporting system. METHODS A cross-sectional survey was conducted in 2006 among GPs who were attending or had attended a local postgraduate family medicine course. RESULTS One hundred and seventy-one GPs participated in this study, among which only 8.9% received formal child abuse training. Only 35.8% of those GPs who had encountered suspected cases reported every case. GPs who considered reporting could produce more harm than good to the family or child, who concerned about maintaining anonymity and who were reluctant to get involved with legal system were less likely to make a report [odds ratio (OR) 0.21-0.27; 95% confidence interval (CI) 0.06-0.11, 0.67-0.86]. 'Concern on own anonymity' was the only significant independent predictor for reporting (OR 3.47; 95% CI 1.11-10.87). Despite the low satisfaction with the present reporting system, 67.3% would not support the introduction of a mandatory reporting system. Logistic regression showed previous training could predict supportive attitude towards mandatory reporting (OR 4.84, 95% CI 1.01-23.27). CONCLUSIONS This study shows low reporting behaviour among Hong Kong GPs. The major barriers to report are identified and can only be addressed by education and a carefully designed support system for GPs. Further research engaging a multidisciplinary approach is required to work towards an optimally beneficial system for the children.
On the interpretation of local models in blended multiple model structures.

The construction of non-linear dynamics by means of interpolating the behaviour of locally valid models offers an attractive and intuitively pleasing method of modelling non-linear systems. The approach is used in fuzzy logic modelling, operating regime based models, and nonlinear statistical models. The model structure suggests that the composite local models can be used to interpret, in some appropriate manner, the overall non-linear dynamics. In this paper we demonstrate that the interpretation of these local models, in the context of multiple model structures, is not as straightforward as it might initially appear. We argue that the blended multiple model system can be interpreted in two ways – as an interpolation of linearisations, or as a full parameterisation of the system. The choice of interpretation affects experiment design, parameter identification, and model validation. We then show that, in some cases, the local models give insight into full model behaviour only in a very small region of state space. More alarmingly, we demonstrate that for off-equilibrium behaviour, subject to some approximation error, a non-unique parameterisation of the model dynamics exists. Hence, qualitative conclusions drawn from the behaviour of an identified local model, e.g. regarding stable, unstable, nodal or complex behaviour, must be treated with extreme caution. The example of muscle modelling is used to illustrate these points clearly.
Specificity, diversity, and convergence in VEGF and TNF‐α signaling events leading to tissue factor up regulation via EGR‐1 in endothelial cells

Tissue factor (TF) has been shown to be up‐regulated in endothelial cells by the inflammatory cytokine tumor necrosis factor a (TNF‐α) as well as by the main angiogenic factor VEGF. Since both stimuli induce the transcription factor EGR‐1, which is critically involved in TF gene regulation, we used EGR‐1‐dependent TF induction as a model to identify potential cross‐talks between the various signal transduction cascades initiated by VEGF and TNF‐α. The data show that at the MAP kinase level, VEGF mainly activates ERK1/2 and p38 MAP kinases in human endothelial cells. TNF‐α is able to activate all three MAP kinase cascades as well as the classical inflammatory IκB/NFκB pathway. Furthermore, the MEK/ERK module of MAP kinases appears to act as the convergence point of VEGF‐ and TNF‐α‐initiated signaling cascades, which lead to the activation of EGR‐1 and subsequent TF expression, whereas the upstream signals are distinct. We found that induction of TF by VEGF via EGR‐1 is strongly PKC dependent. The TNF‐α‐initiated MEK/ERK cascade connected to EGR‐1 and TF expression is clearly less sensitive to PKC inhibition. TNF‐α‐mediated activation of MEK/ERK and EGR‐1 can be blocked by adenoviral expression of a dominant negative mutant of IKK2, whereas the VEGF signaling pathway is unaffected. Thus, our data demonstrate a new link between the classical inflammatory IKK/IκB and the MEK/ERK cascades triggered by TNF‐α. The additional finding that EGF induces ERK and EGR‐1 in a PKC independent manner and that this signal is not sufficient to up‐regulate TF emphasizes the importance of a VEGF‐specific signaling pattern for the induction of TF. — Mechtcheriakova, D. , Schabbauer, G. , Lucerna, M. , Clauss, M. , de Martin, R. , Binder, B. R. , Hofer, E. Specificity, diversity, and convergence in VEGF and TNF‐α signaling events leading to tissue factor up‐regulation via EGR‐1 in endothelial cells. FASEB J. 15, 230–242 (2001)
Mosaic VSGs and the Scale of Trypanosoma brucei Antigenic Variation

A main determinant of prolonged Trypanosoma brucei infection and transmission and success of the parasite is the interplay between host acquired immunity and antigenic variation of the parasite variant surface glycoprotein (VSG) coat. About 0.1% of trypanosome divisions produce a switch to a different VSG through differential expression of an archive of hundreds of silent VSG genes and pseudogenes, but the patterns and extent of the trypanosome diversity phenotype, particularly in chronic infection, are unclear. We applied longitudinal VSG cDNA sequencing to estimate variant richness and test whether pseudogenes contribute to antigenic variation. We show that individual growth peaks can contain at least 15 distinct variants, are estimated computationally to comprise many more, and that antigenically distinct ‘mosaic’ VSGs arise from segmental gene conversion between donor VSG genes or pseudogenes. The potential for trypanosome antigenic variation is probably much greater than VSG archive size; mosaic VSGs are core to antigenic variation and chronic infection.
Emmprin Promotes Anchorage-Independent Growth in Human Mammary Carcinoma Cells by Stimulating Hyaluronan Production

Emmprin (CD147; basigin) is a plasma membrane glycoprotein, enriched on the surface of many cancer cells, which induces matrix metalloproteinase synthesis via cell-cell interactions. Elevated emmprin production causes increased growth in vivo of human mammary carcinoma cells. In this study, we show that elevation of emmprin expression in less aggressive human carcinoma cells, which normally express low emmprin levels, induces the ability to grow under anchorage-independent conditions. We also found that elevated emmprin expression stimulates hyaluronan production and that the effect of emmprin on anchorage-independent growth is dependent on hyaluronan. Furthermore, emmprin stimulates cell survival pathway signaling in a hyaluronan-dependent manner. From these and other studies we conclude that emmprin enhances several malignant properties of cancer cells, including anchorage-independent growth, invasiveness, and chemoresistance.
A Dual-Process Model of Decision-Making: The Symmetric Effect of Intuitive and Cognitive Judgments on Optimal Budget Allocation

Understanding the influence of a dual-processing system on budget waste resulting from choice inconsistencies is critical in helping individuals maximize decision utility. In 2 studies, we rely on the generalized axiom of revealed preferences to explore the severity of choice inconsistencies resulting from intuitive and cognitive judgments separately, as well as overall severity across the 2 types of judgments. We focus on choice inconsistency that leads to the inefficient use of individuals’ budget and not on the simple preference divergence that may result from the 2 types of judgments. We find that budget waste resulting from intuitive and cognitive judgments is comparable but that overall budget waste across the 2 types of judgments is significantly higher. These findings suggest that the inconsistency in choices resulting from intuitive versus cognitive judgments is responsible for significant loss of decision utility in individuals’ economic decisions, rather than choice inconsistencies resulting from a specific type of evaluation in itself. We discuss theoretical and practical implications of our findings.
Parallel Computation of Skyline Queries

Due to stagnant clock speeds and high power consumption of commodity microprocessors, database vendors have started to explore massively parallel co-processors such as FPGAs to further increase performance. A typical approach is to push simple but compute-intensive operations (e.g., prefiltering, (de)compression) to FPGAs for acceleration. In this paper, we show how a significantly more complex operation- the computation of the skyline-can be holistically implemented on an FPGA. A skyline query computes the pareto optimal set of multi-dimensional data points. These queries have been studied in software extensively over the last decade but this paper is the first to examine skyline computation in hardware. We propose a methodology that interleaves data storage and computation, allowing multiple operations to be executed on the same working set in parallel, while accounting for all data dependencies. Our experiments show that we achieve very promising results compared to CPU-based solutions.
Asymptotic Design and Analysis of Linear Detectors for Asynchronous CDMA Systems

The asymptotic performance of the linear MMSE detector for any finite observation window and any symbol impinging the observed signal is derived for asynchronous but chip synchronous CDMA systems with random spreading. Additionally, a multistage detector that does not suffer from windowing effects and performs as well as the correspondent detector in synchronous systems is proposed. In contrast to the synchronous case, considering a sufficient large delay, the proposed multistage detector can even outperform the full rank linear MMSE detector constrained to a finite fixed observation window.
The international workshop on meibomian gland dysfunction: report of the clinical trials subcommittee.

We suggest the following main priorities in future clinical trials in MGD: Natural history of MGD The association between MGD and dry eye disease A specific and validated questionnaire for symptoms of MGD Standardized grading for lid and other signs in MGD Feasibility and clinical value of lipidomic and protein inflammatory mediators Validation of surrogate clinical outcomes related to MGD. Footnotes Supported by the Tear Film and Ocular Surface Society (TFOS: http://www.tearfilm.org): individual author support is listed in the Appendix of the Introduction. Disclosure: Each Workshop Participant's disclosure data can be found in the Appendix of the Introduction.
Three-Spin Giant Magnons in AdS_5xS^5

From the Polyakov string action using a conformal gauge we construct a three-spin giant magnon solution describing a long open string in AdS_5 \times S^5 which rotates both in two angular directions of S^5 and in one angular direction of AdS_5. Through the Virasoro constraints the string motion in AdS_5 takes an effect from the string configuration in S^5. The dispersion relation of the soliton solution is obtained as a superposition of two bound states of magnons. We show that there is a correspondence between a special giant magnon in AdS_2 and the sinh-Gordon soliton.
Assessing rule interestingness with a probabilistic measure of deviation from equilibrium

Assessing rule interestingness is the cornerstone of successful applications of association rule discovery. In this article, we present a new measure of interestingness named IPEE. It has the unique feature of combining the two following characteristics: first, it is based on a probabilistic model, and secondly, it measures the deviation from what we call equilibrium (maximum uncertainty of the consequent given that the antecedent is true). We study the properties of this new index and show in which cases it is more useful than a measure of deviation from independence.
Neural Machine Translation with Pivot Languages

While recent neural machine translation approaches have delivered state-of-the-art performance for resource-rich language pairs, they suffer from the data scarcity problem for resource-scarce language pairs. Although this problem can be alleviated by exploiting a pivot language to bridge the source and target languages, the source-to-pivot and pivot-to-target translation models are usually independently trained. In this work, we introduce a joint training algorithm for pivot-based neural machine translation. We propose three methods to connect the two models and enable them to interact with each other during training. Experiments on Europarl and WMT corpora show that joint training of source-to-pivot and pivot-to-target models leads to significant improvements over independent training across various languages.
Algebraic tori - thirty years after

This is an expanded version of my talk given at the International Conference ``Algebra and Number Theory'' dedicated to the 80th anniversary of V. E. Voskresenskii, which was held at the Samara State University in May 2007. The goal is to give an overview of results of V. E. Voskresenskii on arithmetic and birational properties of algebraic tori which culminated in his monograph "Algebraic Tori" published in Russian 30 years ago. I shall try to put these results and ideas into somehow broader context and also to give a brief digest of the relevant activity related to the period after the English version of the monograph "Algebraic Groups and Their Birational Invariants" appeared.
Isolation of cytomegalovirus and clinical manifestations of infection at different ages.

observed, and was often best supplied when the decision to increase the dose was left to the patient: this must, however, depend on an assessment of each individual's personality. Antibiotics given early during infections of the upper respiratory tract also appeared to reduce the risk of serious relapse. We reiterate the view that long-term steroid therapy is a valuable form of treatment, but it must be used circumspectly, with adequate supervision and full collaboration between the hospital consultant and the family physician. Though steroids often enable patients to lead a more active and useful life, attacks of severe asthma may still occur, and need urgent and thorough treatment.