Miracle-dz/UniFAR-FTUs huggingface dataset:
Bubble-up: Increasing utilization in modern warehouse scale computers via sensible co-locations

As much of the world's computing continues to move into the cloud, the overprovisioning of computing resources to ensure the performance isolation of latency-sensitive tasks, such as web search, in modern datacenters is a major contributor to low machine utilization. Being unable to accurately predict performance degradation due to contention for shared resources on multicore systems has led to the heavy handed approach of simply disallowing the co-location of high-priority, latency-sensitive tasks with other tasks. Performing this precise prediction has been a challenging and unsolved problem. In this paper, we present Bubble-Up, a characterization methodology that enables the accurate prediction of the performance degradation that results from contention for shared resources in the memory subsystem. By using a bubble to apply a tunable amount of “pressure” to the memory subsystem on processors in production datacenters, our methodology can predict the performance interference between co-locate applications with an accuracy within 1% to 2% of the actual performance degradation. Using this methodology to arrive at “sensible” co-locations in Google's production datacenters with real-world large-scale applications, we can improve the utilization of a 500-machine cluster by 50% to 90% while guaranteeing a high quality of service of latency-sensitive applications.
Obesity and Associated Factors — Kingdom of Saudi Arabia, 2013

Introduction Data on obesity from the Kingdom of Saudi Arabia (KSA) are nonexistent, making it impossible to determine whether the efforts of the Saudi Ministry of Health are having an effect on obesity trends. To determine obesity prevalence and associated factors in the KSA, we conducted a national survey on chronic diseases and their risk factors. Methods We interviewed 10,735 Saudis aged 15 years or older (51.1% women) through a multistage survey. Data on sociodemographic characteristics, health-related habits and behaviors, diet, physical activity, chronic diseases, access to and use of health care, and anthropometric measurements were collected through computer-assisted personal interviews. We first compared sociodemographic factors and body mass index between men and women. Next, we conducted a sex-specific analysis for obesity and its associated factors using backward elimination multivariate logistic regression models. We used SAS 9.3 for the statistical analyses and to account for the complex sampling design. Results Of the 10,735 participants evaluated, 28.7% were obese (body mass index ≥30 kg/m2). Prevalence of obesity was higher among women (33.5% vs 24.1%). Among men, obesity was associated with marital status, diet, physical activity, diagnoses of diabetes and hypercholesterolemia, and hypertension. Among women, obesity was associated with marital status, education, history of chronic conditions, and hypertension. Conclusion Obesity remains strongly associated with diabetes, hypercholesterolemia, and hypertension in the KSA, although the epidemic’s characteristics differ between men and women.
Pharmacological Effect of Caulophyllum robustum on Collagen-Induced Arthritis and Regulation of Nitric Oxide, NF-κB, and Proinflammatory Cytokines In Vivo and In Vitro

Caulophyllum robustum Maxim (C. robustum) has commonly been used as traditional Chinese medicine for the treatment of rheumatic pain and rheumatoid arthritis (RA) in China. This paper first investigated the anti-inflammation effect of C. robustum extraction (CRME) on RAW264.7 cells stimulated by lipopolysaccharide (LPS) and gene expression levels of inflammatory factors. Moreover, we first evaluated the anti-RA effects of CRME using collagen-induced arthritis (CIA) in DBA/1J mice, and the incidence, clinical score, and joint histopathology were evaluated. The levels of IL-1, IL-6, TNF-α, and PGE2 inflammatory factors in sera of mice were detected by enzyme-linked immunosorbent assay. The expression of NF-κB p65 in the joint was tested by immune histochemical technique. The results showed that, compared with the model group, CRME significantly improved symptoms of the arthritis index, limb swelling, and histological findings by decreasing synovial membrane damage, the extent of inflammatory cell infiltration, and the expansion of capillaries in CIA mice. The results also showed that CRME can reduce the levels of IL-1, IL-6, TNF-α, and PGE2 and inhibit the expression of NF-κB p65. All these results indicated the anti-inflammatory efficacy of CRME as a novel botanical extraction for the treatment of RA.
A comparison between computer and tabletop delivery of phonology therapy

This paper reports on the development and evaluation of a software program aimed at assisting children with phonological impairment. An experimental approach was used whereby children's speech output was assessed pre- and post-therapy. Children were randomly assigned to a computer, a tabletop or a no therapy group. Those children receiving the computer therapy were exposed to an experimental software program that mirrored the tabletop activities using interactive computer games. The results showed no significant difference between any of the three groups with regard to change in speech output. These results may relate to the amount and frequency of therapy given and also to the heterogeneous nature of children included in the study. There was considerable variation in individual performance across all three groups and the data were therefore analysed to look for patterns that might predict performance. Stimulability and gender were identified as possible predictors. Female children and those who were able to produce a greater number of consonant speech sounds in isolation were more likely to make progress in their speech output. Future research might use a similar methodology to compare the therapy conditions but with a more homogenous group in terms of stimulability and using a greater intensity of intervention.
Reduced Methane Emissions from Santa Barbara Marine Seeps

Airborne in situ and remote sensing measurements of methane were performed over the marine seeps in the Santa Barbara Channel close to the Coal Oil Point in California on two days in June and August 2014 with the aim to re-assess their methane emissions. During this period, methane column averaged dry air mole fractions derived from airborne remote sensing measurements in the short-wave infrared and airborne in situ measurements of methane indicate that emissions are 2–6 kt CH 4 y − 1 , significantly lower than expected from previous publications. This is also confirmed by the on ground in situ measurement time series recorded at the onshore West Campus Monitoring Station in Santa Barbara. Using a time series of methane data, a decline in methane concentrations between 2008 and 2015 of more than a factor of two was derived for air masses originating from the seep field direction.
Possible DNA Viral Factors of Human Breast Cancer

Viruses are considered to be one of the high-risk factors closely related to human breast cancer. However, different studies of viruses in breast cancer present conflicting results and some of these works remain in dispute. DNA viruses, such as specific types of human papillomaviruses (HPV), Epstein–Barr virus (EBV), human cytomegalovirus (HCMV), herpes simplex virus (HSV), and human herpes virus type 8 (HHV-8), have emerged as causal factors of some human cancers. These respective exogenous viruses and the possibility of multiple viral factors are discussed in this review.
The Potential Role of Trained Immunity in Autoimmune and Autoinflammatory Disorders

During induction of trained immunity, monocytes and macrophages undergo a functional and transcriptional reprogramming toward increased activation. Important rewiring of cellular metabolism of the myeloid cells takes place during induction of trained immunity, including a shift toward glycolysis induced through the mTOR pathway, as well as glutaminolysis and cholesterol synthesis. Subsequently, this leads to modulation of the function of epigenetic enzymes, resulting in important changes in chromatin architecture that enables increased gene transcription. However, in addition to the beneficial effects of trained immunity as a host defense mechanism, we hypothesize that trained immunity also plays a deleterious role in the induction and/or maintenance of autoimmune and autoinflammatory diseases if inappropriately activated.
American Finance Association Do Industries Explain Momentum ?

This paper documents a strong and prevalent momentum effect in industry components of stock returns which accounts for much of the individual stock momentum anomaly. Specifically, momentum investment strategies, which buy past winning stocks and sell past losing stocks, are significantly less profitable once we control for industry momentum. By contrast, industry momentum investment strategies, which buy stocks from past winning industries and sell stocks from past losing industries, appear highly profitable, even after controlling for size, book-to-market equity, individual stock momentum, the cross-sectional dispersion in mean returns, and potential microstructure influences. BOTH INVESTMENT THEORY AND ITS APPLICATION to investment management critically depend on our field's understanding of stock return persistence anomalies. Determining whether these anomalies are rooted in behavior that can be exploited by more rational investors at low risk has profound implications for our view of market efficiency and optimal investment policy. The ability to outperform buy-and-hold strategies by acquiring past winning stocks and selling past losing stocks, commonly referred to as "individual stock momentum," remains one of the most puzzling of these anomalies, both because of its magnitude (up to 12 percent abnormal return per dollar long on a self-financing strategy per year) and because of the peculiar horizon pattern that it seems to follow: Trading based on individual stock momentum appears to be a poor strategy when using a short historical horizon for portfolio formation (especially less than one month); it is highly *Moskowitz is from the Graduate School of Business, University of Chicago (tobias. moskowitz@gsb.uchicago.edu), and Grinblatt is from the Anderson School, University of California at Los Angeles (mgrinbla@anderson.ucla.edu). We thank Kobi Boudoukh, Ty Callahan, Kent Daniel, Gordon Delianedis, Gene Fama, Rick Green, Jonathan Howe, Narasimhan Jegadeesh, Olivier Ledoit, Richard Roll, Pedro Santa-Clara, Ren6 Stulz, Sheridan Titman, Ralph Walkling, Russ Wermers, David Wessels, two anonymous referees, and seminar participants at UCLA, Yale, Harvard, Rochester, Ohio State, Wharton, Columbia, Duke, the University of Colorado at Boulder, the University of Texas at Austin, the University of Chicago, Northwestern, the University of Michigan, the 1998 WFA meetings in Monterey, CA, the 1998 NBER Asset Pricing Conference in Chicago, and the 1999 AFA meetings in New York for valuable comments and insights. Moskowitz thanks the Center for Research in Securities Prices as well as the Dimensional Fund Advisors Research Fund for financial support. Grinblatt thanks the UCLA Academic Senate for financial support.
Challenges and Alternatives to Plastics Recycling in the Automotive Sector

Plastics are increasingly a preferred material choice in designing and developing complex, consumer products, such as automobiles, because they are mouldable, lightweight, and are often perceived to be highly recyclable materials. However, actually recycling the heterogeneous plastics used in such durable items is challenging, and presents very different scenarios to how simple products, such as water bottles, are recovered via curbside or container recycling initiatives. While the technology exists to recycle plastics, their feasibility to do so from high level consumer or industrial applications is bounded by technological and economical restraints. Obstacles include the lack of market for recyclates, and the lack of cost efficient recovery infrastructures or processes. Furthermore, there is a knowledge gap between manufacturers, consumers, and end-of-life facility operators. For these reasons, end-of-life plastics are more likely to end up down-cycled, or as shredder residue and then landfilled. This paper reviews these challenges and several alternatives to recycling plastics in order to broaden the mindset surrounding plastics recycling to improve their sustainability. The paper focuses on the automotive sector for examples, but discussion can be applied to a wide range of plastic components from similarly complex products.
Comparison of white blood cell counts by WNR, WDF, and WPC channels in Sysmex XN hematology analyzer

The Sysmex XN modular system (Sysmex, Kobe, Japan) uses a novel technology for white blood cell (WBC) count and differential, using separate channels: white cell nucleated (WNR), WBC differential (WDF), and white progenitor cell (WPC) channels. We questioned how concordant WBC counts would be between them.
Anti-Persistence on Persistent Storage: History-Independent Sparse Tables and Dictionaries

We present history-independent alternatives to a B-tree, the primary indexing data structure used in databases. A data structure is history independent (HI) if it is impossible to deduce any information by examining the bit representation of the data structure that is not already available through the API. We show how to build a history-independent cache-oblivious B-tree and a history-independent external-memory skip list. One of the main contributions is a data structure we build on the way---a history-independent packed-memory array (PMA). The PMA supports efficient range queries, one of the most important operations for answering database queries. Our HI PMA matches the asymptotic bounds of prior non-HI packed-memory arrays and sparse tables. Specifically, a PMA maintains a dynamic set of elements in sorted order in a linear-sized array. Inserts and deletes take an amortized O(log2 N) element moves with high probability. Simple experiments with our implementation of HI PMAs corroborate our theoretical analysis. Comparisons to regular PMAs give preliminary indications that the practical cost of adding history-independence is not too large. Our HI cache-oblivious B-tree bounds match those of prior non-HI cache-oblivious B-trees. Searches take O(logB N) I/Os; inserts and deletes take O((log2 N)/B+ logB N) amortized I/Os with high probability; and range queries returning k elements take O(logB N + k/B) I/Os. Our HI external-memory skip list achieves optimal bounds with high probability, analogous to in-memory skip lists: O(logB N) I/Os for point queries and amortized O(logB N) I/Os for inserts/deletes. Range queries returning k elements run in O(logB N + k/B) I/Os. In contrast, the best possible high-probability bounds for inserting into the folklore B-skip list, which promotes elements with probability 1/B, is just Theta(log N) I/Os. This is no better than the bounds one gets from running an in-memory skip list in external memory.
0.5 Petabyte Simulation of a 45-Qubit Quantum Circuit

Near-term quantum computers will soon reach sizes that are challenging to directly simulate, even when employing the most powerful supercomputers. Yet, the ability to simulate these early devices using classical computers is crucial for calibration, validation, and benchmarking. In order to make use of the full potential of systems featuring multi- and many-core processors, we use automatic code generation and optimization of compute kernels, which also enables performance portability. We apply a scheduling algorithm to quantum supremacy circuits in order to reduce the required communication and simulate a 45-qubit circuit on the Cori II supercomputer using 8, 192 nodes and 0.5 petabytes of memory. To our knowledge, this constitutes the largest quantum circuit simulation to this date. Our highly-tuned kernels in combination with the reduced communication requirements allow an improvement in time-to-solution over state-of-the-art simulations by more than an order of magnitude at every scale. CCS CONCEPTS Applied computing $\rightarrow$ Physics;
Feedback inhibition of ENaC: Acute and chronic mechanisms

Intracellular [Na+] ([Na+]i) modulates the activity of the epithelial Na channel (ENaC) to help prevent cell swelling and regulate epithelial Na+ transport, but the underlying mechanisms remain unclear. We show here that short-term (60–80 min) incubation of ENaC-expressing oocytes in high Na+ results in a 75% decrease in channel activity. When the β subunit was truncated, corresponding to a gain-of-function mutation found in Liddle's syndrome, the same maneuver reduced activity by 45% despite a larger increase in [Na+]i. In both cases the inhibition occurred with little to no change in cell-surface expression of γENaC. Long-term incubation (18 hours) in high Na+ reduced activity by 92% and 75% in wild-type channels and Liddle's mutant, respectively, with concomitant 70% and 52% decreases in cell-surface γENaC. In the presence of Brefeldin A to inhibit forward protein trafficking, high-Na+ incubation decreased wt ENaC activity by 52% and 88% after 4 and 8 hour incubations, respectively. Cleaved γENaC at the cell surface had lifetimes at the surface of 6 hrs in low Na+ and 4 hrs in high Na+, suggesting that [Na+]i increased the rate of retrieval of cleaved γ ENaC by 50%. This implies that enhanced retrieval of ENaC channels at the cell surface accounts for part, but not all, of the downregulation of ENaC activity shown with chronic increases in [Na+]i.
Angle and frequency dependence of self-energy from spin fluctuation mediated d-wave pairing for high temperature superconductors

We investigated the characteristics of spin fluctuation mediated superconductivity employing the Eliashberg formalism. The effective interaction between electrons was modeled in terms of the spin susceptibility measured by inelastic neutron scattering experiments on single crystal La2−xSrxCuO4 superconductors. The diagonal self-energy and off-diagonal self-energy were calculated by solving the coupled Eliashberg equation self-consistently for the chosen spin susceptibility and tight-binding dispersion of electrons. The full momentum and frequency dependence of the self-energy is presented for optimally doped, overdoped, and underdoped LSCO cuprates in a superconductive state. These results may be compared with the experimentally deduced self-energy from ARPES experiments.
Biological Cost of Different Mechanisms of Colistin Resistance and Their Impact on Virulence in Acinetobacter baumannii

ABSTRACT Two mechanisms of resistance to colistin have been described in Acinetobacter baumannii. One involves complete loss of lipopolysaccharide (LPS), resulting from mutations in lpxA, lpxC, or lpxD, and the second is associated with phosphoethanolamine addition to LPS, mediated through mutations in pmrAB. In order to assess the clinical impacts of both resistance mechanisms, A. baumannii ATCC 19606 and its isogenic derivatives, AL1851 ΔlpxA, AL1852 ΔlpxD, AL1842 ΔlpxC, and ATCC 19606 pmrB, were analyzed for in vitro growth rate, in vitro and in vivo competitive growth, infection of A549 respiratory alveolar epithelial cells, virulence in the Caenorhabditis elegans model, and virulence in a systemic mouse infection model. The in vitro growth rate of the lpx mutants was clearly diminished; furthermore, in vitro and in vivo competitive-growth experiments revealed a reduction in fitness for both mutant types. Infection of A549 cells with ATCC 19606 or the pmrB mutant resulted in greater loss of viability than with lpx mutants. Finally, the lpx mutants were highly attenuated in both the C. elegans and mouse infection models, while the pmrB mutant was attenuated only in the C. elegans model. In summary, while colistin resistance in A. baumannii confers a clear selective advantage in the presence of colistin treatment, it causes a noticeable cost in terms of overall fitness and virulence, with a more striking reduction associated with LPS loss than with phosphoethanolamine addition. Therefore, we hypothesize that colistin resistance mediated by changes in pmrAB will be more likely to arise in clinical settings in patients treated with colistin.
Mechanism underlying the negative effect of prostate volume on the outcome of extensive transperineal ultrasound‐guided template prostate biopsy

Previous studies have indicated a possible relationship between increased prostate volume (PV) and decreased biopsy yield, although the mechanism involved is unclear. We evaluated 1650 patients who underwent template biopsy. The distribution of 993 cancer lesions in 302 prostatectomy specimens was compared with the biopsy data to determine whether each lesion was detected. A receiver operating characteristic (ROC) model was used to determine the diagnostic accuracy of prostate‐specific antigen (PSA) and related markers. A medical record number (MRN) was used as a negative control. The cancer positive rate did not change as PSA increased in patients with PV ≥50 mL (P = 0.466), although it increased as PSA increased in patients with PV<50 mL (P = 0.001). The detection rate of cancer lesions decreased as the diameter of the lesions decreased (P = 0.018), but remained unchanged with respect to PV. The diameters of the maximum lesions in patients with PV ≥ 50 mL were significantly smaller than those in patients with PV<50 mL (P = 0.003). In patients with PV ≥ 50 mL, the areas under the ROC curves for PSA‐related markers did not differ significantly from that for MRN, although they were significantly greater than that for MRN in patients with PV<50 mL (P < 0.001). These results suggest that an increase in PV is associated with a decrease in size and detectability of cancer lesions resulting in a decrease in biopsy yield. Loss of diagnostic accuracy of markers in patients with PV ≥ 50 mL indicates a decrease in serum levels of PSA produced by prostate cancer, which suggests growth inhibition of the cancer.
Towards clinical development of a Pfs48/45-based transmission blocking malaria vaccine

ABSTRACT Introduction: Malaria is a devastating vector-borne disease caused by the Plasmodium parasite, resulting in almost 0.5 million casualties per year. The parasite has a complex life-cycle that includes asexual replication in human red blood cells, causing symptomatic malaria, and sexual stages which are essential for the transmission to the mosquito vector. A vaccine targeting the sexual stages of the parasite and thus blocking transmission will be instrumental for the eradication of malaria. One of the leading transmission blocking vaccine candidates is the sexual stage antigen Pfs48/45. Areas covered: PubMed was searched to review the progress and future prospects for clinical development of a Pfs48/45-based subunit vaccine. We will focus on biological function, naturally acquired immunity, functional activity of specific antibodies, sequence diversity, production of recombinant protein and preclinical studies. Expert commentary: Pfs48/45 is one of the lead-candidates for a transmission blocking vaccine and should be further explored in clinical trials.