Miracle-dz/UniFAR-FTUs huggingface dataset:
Multivariate Methods for the Comparison of Factor Structures in Cross-Cultural Research

The goal of the present study was to demonstrate the value of a multiple data analytic approach for testing the cross-cultural generalizability of a personality measure. Data were collected in four different countries (Italy, Germany, Spain, and the United States) on the Big Five Questionnaire (BFQ), which is a measure of the Five Factor Model of personality traits. Different analytical strategies were conducted. Item-level analyses were carried out to study item bias and to select (by means of simultaneous component analysis) the BFQ items that showed better functioning in all countries simultaneously. Scale-level analyses were conducted on item aggregates and were focused on the examination of structural or construct equivalence (i.e., comparability of latent structures). Three analytic approaches were compared (exploratory factor analysis, simultaneous component analysis, and confirmatory factor analysis), and converged in corroborating the basic five factor structure across the four country samples. However, these methods also yielded some noteworthy differences in the conclusions that could be drawn from the analyses. Both the methodological and conceptual implications of this multiple analytic approach are discussed.
Citizen Journalism and Democracy: How User-Generated News Use Relates to Political Knowledge and Participation

The contribution of professional journalism to democratic citizenship is well-established, but the proliferation of online user-generated news begs the question of whether citizen journalism plays a similar role. Use and trust of both professional and citizen journalism were investigated for their associations with political knowledge and participation. User-generated journalism was negatively related with knowledge of national political figures, but strongly and positively associated with higher levels of online and offline participation; professional news media produced gains in knowledge and offline participation. Trust in user-generated news amplified the link between citizen journalism and online participation.
The relative effects of unemployment and quality of employment on the affect, work values and personal control of adolescents

This study examined the relative effects of unemployment and quality of employment on the affective states, personal control and work values of school-leavers. Initially, students were surveyed at school and then reassessed two years later when they were either unemployed, employed or continuing their education. Those in employment were categorized as being in good or poor employment on the basis of the degree to which their jobs allowed them to utilize their skills and education. When school-leavers who obtained good quality employment were compared with those who were unemployed, they had lower depressive affect, higher life-satisfaction, higher internal control and higher personal competence. However, there was little difference on these variables between the unemployed and the poor employment groups. Both of these groups, when compared with students and those in good employment, had higher depressive affect, lower work values and lower personal control. All of these results were confirmed when analyses controlled for testing effects and initial differences on the dependent variables. These results show that the relative effects of employment and unemployment upon adolescents depend on the quality of experienced employment.
Global Dynamics of an SEIR Epidemic Model with Vertical Transmission

We study a population model for an infectious disease that spreads in the host population through both horizontal and vertical transmission. The total host population is assumed to have constant density and the incidence term is of the bilinear mass-action form. We prove that the global dynamics are completely determined by the basic reproduction number R0 (p,q), where p and q are fractions of infected newborns from the exposed and infectious classes, respectively. If $R_0(p,q)\le 1,$ the disease-free equilibrium is globally stable and the disease always dies out. If R0 (p,q)>1, a unique endemic equilibrium exists and is globally stable in the interior of the feasible region, and the disease persists at an endemic equilibrium state if it initially exists. The contribution of the vertical transmission to the basic reproduction number is also analyzed.
Professionals, Managers and Discretion: Critiquing Street-Level Bureaucracy

Social workers are classic street-level bureaucrats. This article provides a critical examination of Michael Lipsky’s account of discretion within street-level bureaucracies. While concurring with the main thrust of Lipsky’s critique of management control of discretion, I argue that he gives insufficient attention to the role of professionalism in his analysis and the impact this has on the relationship between front line managers and workers and the nature of discretion. I employ a qualitative case study of adult social work within a local authority to illustrate and develop this argument. The study, which draws primarily on interviews with local managers and practitioners, suggests that the professional status of social workers influences both the nature of their discretion and the way in which this is managed. I conclude that Lipksy’s work needs to be augmented by an understanding of the role of other perspectives, such as professionalism, in examining manager–worker relations and discretion in the street-level bureaucracies within which social workers practise.
Random Responding as a Threat to the Validity of Effect Size Estimates in Correlational Research

Random responding to psychological inventories is a long-standing concern among clinical practitioners and researchers interested in interpreting idiographic data, but it is typically viewed as having only a minor impact on the statistical inferences drawn from nomothetic data. This article explores the impact of random responding on the size and direction of correlations observed between multi-item inventory scores. Random responses to individual items result in nonrandomly distributed inventory-level scores. Therefore, even low base rates of random responding can significantly affect the statistical inferences made from inventory-level data. Study 1 uses simulations to show that even low base rates of random responding can significantly affect observed correlations, especially when the inventories in question assess low or high base rate phenomena. Study 2 uses archival data to illustrate the moderating effect of random responding on observed correlations in two samples.
Variable Identities in Brussels. The Relationship Between Language Learning, Motivation and Identity in a Multilingual Context

Abstract In Belgium and Brussels, macrocontextual features such as language policy and language legislation have a profound impact on people's language use and on the way languages are learned. In order to explain this impact, the political and economic developments that have determined the current context of learners in Brussels are discussed. Secondly, a number of recent events that are the result of the interplay of language legislation and sociolinguistic mechanisms are presented. These contextual issues are linked to some theoretical insights which allow us to look at: (1) how the specific context of Brussels influences instructed and non-instructed L2 learning; (2) what the implications are for learners’ identification processes; and (3) how this relates to their L2 learning motivation. These questions are addressed in an empirical study carried out in a Dutch-speaking secondary school in Brussels. The results suggest that adolescents in Dutch-speaking schools in Brussels have variable identity profiles and specific L2 learning motivations, depending on their language use in different contexts.
A Prognostic Model Based on Preoperative MRI Predicts Overall Survival in Patients with Diffuse Gliomas

BACKGROUND AND PURPOSE: Diffuse gliomas are classified as grades II–IV on the basis of histologic features, with prognosis determined mainly by clinical factors and histologic grade supported by molecular markers. Our aim was to evaluate, in patients with diffuse gliomas, the relationship of relative CBV and ADC values to overall survival. In addition, we also propose a prognostic model based on preoperative MR imaging findings that predicts survival independent of histopathology. MATERIALS AND METHODS: We conducted a retrospective analysis of the preoperative diffusion and perfusion MR imaging in 126 histologically confirmed diffuse gliomas. Median relative CBV and ADC values were selected for quantitative analysis. Survival univariate analysis was made by constructing survival curves by using the Kaplan-Meier method and comparing subgroups by log-rank probability tests. A Cox regression model was made for multivariate analysis. RESULTS: The study included 126 diffuse gliomas (median follow-up of 14.5 months). ADC and relative CBV values had a significant influence on overall survival. Median overall survival for patients with ADC < 0.799 × 10−3 mm2/s was <1 year. Multivariate analysis revealed that patient age, relative CBV, and ADC values were associated with survival independent of pathology. The preoperative model provides greater ability to predict survival than that obtained by histologic grade alone. CONCLUSIONS: ADC values had a better correlation with overall survival than relative CBV values. A preoperative prognostic model based on patient age, relative CBV, and ADC values predicted overall survival of patients with diffuse gliomas independent of pathology. This preoperative model provides a more accurate predictor of survival than histologic grade alone.
Quantized vs. Analog Feedback for the MIMO Broadcast Channel: A Comparison between Zero-Forcing Based Achievable Rates

We consider a MIMO fading broadcast channel and compare the achievable ergodic rates when the channel state information at the transmitter is provided by "analog" noisy feedback or by quantized (digital) feedback. The superiority of digital feedback is shown, with perfect or imperfect CSIR, whenever the number of feedback channel uses per channel coefficient is larger than 1. Also, we show that by proper design of the digital feedback link, errors in the feedback have a minor effect even by using very simple uncoded modulation. Finally, we show that analog feedback achieves a fraction 1 - 2F of the optimal multiplexing gain even in the presence of a feedback delay, when the fading belongs to the class of "Doppler processes" with normalized maximum Doppler frequency shift 0 les F les 1/2.
Seeking a Mechanism for the Toxicity of Oligomeric α-Synuclein

In a number of neurological diseases including Parkinson’s disease (PD), α‑synuclein is aberrantly folded, forming abnormal oligomers, and amyloid fibrils within nerve cells. Strong evidence exists for the toxicity of increased production and aggregation of α-synuclein in vivo. The toxicity of α-synuclein is popularly attributed to the formation of “toxic oligomers”: a heterogenous and poorly characterized group of conformers that may share common molecular features. This review presents the available evidence on the properties of α-synuclein oligomers and the potential molecular mechanisms of their cellular disruption. Toxic α-synuclein oligomers may impact cells in a number of ways, including the disruption of membranes, mitochondrial depolarization, cytoskeleton changes, impairment of protein clearance pathways, and enhanced oxidative stress. We also examine the relationship between α-synuclein toxic oligomers and amyloid fibrils, in the light of recent studies that paint a more complex picture of α-synuclein toxicity. Finally, methods of studying and manipulating oligomers within cells are described.
Vertical transmission of Tetracapsuloides bryosalmonae (Myxozoa), the causative agent of salmonid proliferative kidney disease

SUMMARY The freshwater bryozoan, Fredericella sultana, is the main primary host of the myxozoan endoparasite, Tetracapsuloides bryosalmonae which causes proliferative kidney disease (PKD) of salmonid fish. Because spores that develop in bryozoan colonies are infectious to fish, bryozoans represent the ultimate source of PKD. Bryozoans produce numerous seed-like dormant stages called statoblasts that enable persistence during unfavourable conditions and achieve long-distance dispersal. The possibility that T. bryosalmonae may undergo vertical transmission via infection of statoblasts has been the subject of much speculation since this is observed in close relatives. This study provides the first evidence that such vertical transmission of T. bryosalmonae is extensive by examining the proportions of infected statoblasts in populations of F. sultana on two different rivers systems and confirms its effectiveness by demonstrating transmission from material derived from infected statoblasts to fish hosts. Vertical transmission in statoblasts is likely to play an important role in the infection dynamics of both bryozoan and fish hosts and may substantially contribute to the widespread distribution of PKD.
Selective photoreceptor degeneration by intravitreal injection of N-methyl-N-nitrosourea.

PURPOSE To characterize the effects of intravitreal injections of N-methyl-N-nitrosourea (MNU) in comparison to its systemic application as a measure of inducing unilateral photoreceptor degeneration. METHODS Eight-week-old male C57BL/6J mice received either intraperitoneal injections (three animals) or intravitreal injections (24 animals) of MNU in different concentrations and were observed over a period of 2 weeks using full-field electroretinography (ERG), spectral-domain optical coherence tomography (SD-OCT), and immunohistochemistry. RESULTS The intraperitoneal application of MNU showed moderate systemic toxic effects, indicated by a loss of body weight of 12% within the first 2 days. In both eyes the ERG became extinguished, and SD-OCT scans showed a thinning of the retina, predominantly in the outer nuclear layer (ONL). Immunohistochemistry demonstrated the selective loss of rods and cones. Mice that received intravitreal MNU injections displayed nearly no weight loss, and no degeneration of their general welfare was observed. After 2 weeks, ERG, SD-OCT, and immunohistochemistry revealed changes identical to those seen after systemic application in the injected eye, but not in the control eye. CONCLUSIONS The intraperitoneal application of MNU led to moderate systemic side effects in mice and to selective photoreceptor degeneration. Intravitreal injections of MNU also induced photoreceptor degeneration; however, no systemic side effects were observed. This tool may be helpful in larger species, where genetic models of receptor degenerations are not applicable but where the size of the eye is more suitable to study surgical or other approaches to treat blindness caused by receptor degeneration.
Risk Perception of Nuclear Power Plants Among University Students in Northeast Asia After the Fukushima Nuclear Disaster

To examine the perception of nuclear energy risks among Asian university students following the Fukushima nuclear disaster, a standardized questionnaire survey was conducted since July 2011 after the Fukushima disaster. A total of 1814 respondents from 18 universities in China, Japan, Korea, and Taiwan participated in this survey. It showed that students with the following characteristics had a higher preference for “a clear schedule to phase out nuclear power plant (NPP)”: females (adjusted odds ratio [aOR] = 1.84, 95% confidence interval [CI] = 1.44-2.34), in Japan (aOR = 2.81, 95% CI = 2.02-3.90), in China (aOR = 1.48, 95% CI = 1.04-2.09), and with perceived relative risks of cancer incidence greaterthan 1 (aOR = 1.42, 95% CI = 1.07-1.88). “If nuclear energy were phased out,” the opinions on potential electricity shortage were as follows: Japan, aOR = 0.53, 95% CI = 0.40-0.69; China, aOR = 2.46, 95% CI = 1.75-3.45; and associated with academic majors (science/technology, aOR = 0.43, 95% CI = 0.31-0.59; medicine/health science, aOR = 0.64, 95% CI = 0.49-0.84). The results carried essential messages for nuclear energy policy in East Asia.
Newborns’ preference for up–down asymmetrical configurations

The present study was aimed at investigating whether, because of a differential sensitivity between the upper and the lower visual fields, in a visual preference task newborns would orient more frequently and look longer at patterns with a great number of high–contrast areas in the upper or lower visual field. Newborns were presented with three pairs of geometrical stimuli, each composed of a pattern with a greater number of elements in the upper part or a pattern with more elements in the lower part. The results showed a reliable preference for the stimuli that had more elements in the upper than in the lower part. The evidence obtained suggests the possibility that, at birth, the visibility of a stimulus depends not only on its sensory properties, but also on its structural characteristics.
The Rhetoric and Reality of the 'Risk Factor Prevention Paradigm' Approach to Preventing and Reducing Youth Offending

The Risk Factor Prevention Paradigm (RFPP) has become increasingly influential upon government responses to youth offending. This paper critically evaluates `evidence-based' risk-focused research and prevention that coalesces around the RFPP. We highlight the significant issues that surround defining and measuring risk factors, difficulties in interpreting risk factor evidence, the `psycho-reductionism' of much risk-focused research, implementation problems regarding early intervention and methodological debates around evaluating `what works' in risk-focused crime prevention. A discussion of the promising, progressive nature of the RFPP is tempered by an evaluation of the practical and political concerns that impact upon the paradigm.
Three-Dimensional Cardiac Strain Estimation Using Spatio–Temporal Elastic Registration of Ultrasound Images: A Feasibility Study

Current ultrasound methods for measuring myocardial strain are often limited to measurements in one or two dimensions. Cardiac motion and deformation however are truly 3-D. With the introduction of matrix transducer technology, 3-D ultrasound imaging of the heart has become feasible but suffers from low temporal and spatial resolution, making 3-D strain estimation challenging. In this paper, it is shown that automatic intensity-based spatio-temporal elastic registration of currently available 3-D volumetric ultrasound data sets can be used to measure the full 3-D strain tensor. The method was validated using simulated 3-D ultrasound data sets of the left ventricle (LV). Three types of data sets were simulated: a normal and symmetric LV with different heart rates, a more realistic asymmetric normal LV and an infarcted LV. The absolute error in the estimated displacement was between 0.47 plusmn0.23 and 1.00 plusmn0.59 mm, depending on heart rate and amount of background noise. The absolute error on the estimated strain was 9%-21% for the radial strain and 1%-4% for the longitudinal and circumferential strains. No large differences were found between the different types of data sets. The shape of the strain curves was estimated properly and the position of the infarcts could be identified correctly. Preliminary results on clinical data taken in vivo from three healthy volunteers and one patient with an apical aneurism confirmed these findings in a qualitative manner as the strain curves obtained with the proposed method have an amplitude and shape similar to what could be expected.
The Contributory Role of Professionalism in Shaping Contingent Workers' OCB

Based on social exchange and psychological contract theories, Organizational citizenship behavior (OCB) is anchored on the presumption of an established, long-term relationship between an employer and employees. Thus one could conclude that contingent workers lack OCB. This study demonstrates that adding a “professionalism” construct provides correspondence in the literature that previously did not exist. Given that in advancing economies professionalism will be present in a variety of degrees in all occupations, inclusion of such a dimension can signifi
Cell and chloroplast division requires ARTEMIS

Chloroplasts are endosymbiotic organelles of cyanobacterial origin. It seems reasonable to assume that cell division and organelle division still share general principles, as shown for the FtsZ proteins. However, further components involved in this process are largely unknown. Here we describe ARTEMIS, a nuclear-encoded protein of chloroplast inner envelope membranes that is required for organelle division. ARTEMIS consists of three distinct modules: an N-terminal receptor-like region, a centrally positioned glycine-rich stretch containing a nucleoside triphosphate-binding site, and a C-terminal YidC/Oxa1p/Alb3 protein translocase-like domain. Analysis of Arabidopsis En-1 transposon mutants as well as ARTEMIS antisense plants revealed chloroplasts arrested in the late stages of division. Chloroplasts showed clearly separated and distinct multiple thylakoid systems, whereas the final organelle fission remained unaccomplished. Inactivation of a cyanobacterial gene with sequence similarity to the YidC/Oxa1p/Alb3-like domain of ARTEMIS resulted in aberrant cell division, which could be rescued by the Arabidopsis protein. ARTEMIS represents a so-far-unrecognized link between prokaryotic cell fission and chloroplast division.
Clinical development of CAR T cells—challenges and opportunities in translating innovative treatment concepts

Chimeric antigen receptor (CAR) T cell therapy, together with checkpoint inhibition, has been celebrated as a breakthrough technology due to the substantial benefit observed in clinical trials with patients suffering from relapsed or refractory B‐cell malignancies. In this review, we provide a comprehensive overview of the clinical trials performed so far worldwide and analyze parameters such as targeted antigen and indication, CAR molecular design, CAR T cell manufacturing, anti‐tumor activities, and related toxicities. More than 200 CAR T cell clinical trials have been initiated so far, most of which aim to treat lymphoma or leukemia patients using CD19‐specific CARs. An increasing number of studies address solid tumors as well. Notably, not all clinical trials conducted so far have shown promising results. Indeed, in a few patients CAR T cell therapy resulted in severe adverse events with fatal outcome. Of note, less than 10% of the ongoing CAR T cell clinical trials are performed in Europe. Taking lead from our analysis, we discuss the problems and general hurdles preventing efficient clinical development of CAR T cells as well as opportunities, with a special focus on the European stage.
A description of an audit cycle of early dropouts from an inpatient psychotherapy unit

This paper describes the results and implications of an 8-year audit cycle concerning premature termination of treatment in a population with severe personality disorder treated within a specialist residential setting. The results of the first audit showed (a) a high early dropout rate, (b) a significant difference in early dropout rates between the two clinical programmes (one-stage and step-down) offered by the unit, and (c) a higher attrition of non-borderline personality disorders compared to borderline type disorder. Qualitative analysis of interviews with early dropout patients helped to identify deficiencies in practice, which may have contributed to dropout. Discussion of results amongst the team led to corrective measures that allowed reduction of early dropout in the one-stage programme over the subsequent years. The implications of the results are discussed.