Miracle-dz/UniFAR-FTUs huggingface dataset:
Coexistence of Hepatocellular Carcinoma (HCC) and c-Kit Negative Gastrointestinal Stromal Tumor (GIST): A Case Report

A past history of sporadic solid cancers is disclosed in 10% of gastrointestinal stromal tumor (GIST) patients. Simultaneous occurrence with other malignancies is encountered in 14 to 16%, but the synchronous occurrence of GIST and hepatocellular carcinoma (HCC) has been reported only once in the English literature. An 81-year-old male patient is presented with a preoperatively known HCC, in whom a synchronous small nodular omental GIST adjacent to the lesser curvature of the stomach was incidentally discovered. When a GIST is encountered, a thorough intraoperative investigation of the abdominal cavity currently remains the only reliable method for detection of a possible coexisting malignancy.
In Vitro Evaluation of a New Quinolone Antibacterial

The activity of R-802, a quinolone antibacterial agent, was studied in vitro and found to be active against Enterobacteriaceae; less than 4 μg of drug per ml was required to inhibit most isolates. The majority of Pseudomonas aeruginosa grew in a concentration of 256 μg of R-802 per ml when studied in broth against an inoculum of 108 organisms per ml.
Political Consumerism: How Communication and Consumption Orientations Drive “Lifestyle Politics”

Historians and cultural theorists have long asserted that a desire to express political concerns often guides consumer behavior, yet such political consumerism has received limited attention from social scientists. Here, the authors explore the relationship of political consumerism with dispositional factors, communication variables, and consumption orientations using data collected from a panel survey conducted in the United States between February 2002 and July 2005. The authors test a theorized model using both cross-sectional and auto-regressive panel analyses. The static and change models reveal that conventional and online news use encourage political consumerism indirectly through their influence on political talk and environmental concerns. However, media use may also have some suppressive effects by reducing the desire to protect others from harmful messages. Results demonstrate how communication practices and consumption orientations work together to influence political consumerism beyond previously delineated factors. Implications for declines in political and civic participation and youth socialization are discussed.
The Impact of Sex and Gender in the Relationships Among Attachment, Romantic Jealousy, and Varying Forms of Aggression in Adult Romantic Relationships

This study seeks to explicate the impact of sex and gender in the relationships among attachment, romantic jealousy, and aggression. Attachment theory (e.g., Bowlby, 1969) posits that unique attachment styles develop based on experiences with primary caregiver(s). These attachment styles (e.g., secure, preoccupied, dismissing, and fearful) are enduring, and come to define attachment in adult romantic relationships (Bartholomew & Horowitz, 1992; Hazan & Shaver, 1987). Attachment theory argues that differences in jealousy in adult romantic relationships are a function of attachment style (e.g., Guerrero, 1998). Similarly, attachment frameworks explain aggression (e.g., physical, verbal, and indirect/social/relational) as a function of attachment style, suggesting that these constructs (both aggression and jealousy) are borne from early childhood experiences. Theories that posit sex and gender differences, however, argue that aggression and jealousy are rooted in biological (i.e., sex-linked), evolutionary (i.e., adaptive), and social (i.e., learned) explanations of how men and women differ.This study aims to examine these theoretical perspectives in an attempt to further understand how differences between the two (attachment and sex/gender theories) can be explained. Results from this study indicate that sex and gender are unique, and do have differential effects on the relationships among attachment, aggression, and romantic jealousy in romantic relationships. Though the moderating effects of sex and gender are not always strong, findings from this study suggest that biology, evolution, and socialization likely interact and influence variability in attachment, aggression, and romantic jealousy.
Energy-Efficient Resource Allocation in Ultra-Dense Networks with Massive MIMO

We study the energy-efficient resource allocation in ultra-dense networks (UDNs) with massive multiple- input multiple-out (MIMO), where the densely deployed BSs are equipped with massive antenna arrays to communicate with multiple users. Aiming to design a practical resource allocation scheme in the presence of strong interference in UDNs, we propose a semi-distributed interference-aware (IA) resource allocation to achieve high energy efficiency (EE). In particular, a coordinator is introduced to collect the local interference-information estimated by each BS and then fed back the synthesized global interference-information to each BS to enable parallel and cell-wise optimizations. Focusing the capability of massive MIMO in UDNs, we further propose a joint optimization of the active BS antennas, user scheduling and transmission power within the IA resource allocation framework for EE. Numerical results show our IA joint optimization scheme significantly improves the EE performance over the conditional interference-unaware scheme in UDNs with massive MIMO.
GLOBALLY CONVERGENT EVOLUTION STRATEGIES AND CMA-ES

In this paper we show how to modify a large class of evolution strate- gies (ES) to rigorously achieve a form of global convergence, meaning convergence to stationary points independently of the starting point. The type of ES under consideration recombine the parents by means of a weighted sum, around which the offsprings are computed by random generation. One relevant instance of such ES is CMA-ES. The modifications consist essentially of the reduction of the size of the steps whenever a sufficient decrease condition on the function values is not verified. When such a condition is satisfied, the step size can be reset to the step size maintained by the ES themselves, as long as this latter one is sufficientlylarge. We suggest a number of ways of imposing sufficient decrease for which global convergence holds under reasonable assumptions, and extend our theory to the constrained case. Given a limited budget of function evaluations, our numerical experiments have shown that the modified CMA-ES is capable of further progress in function values. Moreover, we have observed that such an improvement in efficiency comes without deteriorating the behavior of the underlying method in the presence of nonconvexity.
High‐resolution projections of extreme heat in New York City

Heat waves impact a wide array of human activities, including health, cooling energy demand, and infrastructure. Cities amplify many of these impacts by concentrating large populations and critical infrastructure in relatively small areas. In addition, heat waves are expected to become longer, more intense, and more frequent in North America. Here, we evaluate combined climate and urban surface impacts on localized heat wave metrics throughout the 21st century across two emissions scenarios (RCP4.5 and RCP8.5) for New York City (NYC), which houses the largest urban population in the United States. We account for local biases due to urban surfaces via bias correcting with observed records and urbanized 1‐km resolution dynamical downscaling simulations across selected time periods (2045–2049 and 2095–2099). Analysis of statistically downscaled global model output shows underestimation of uncorrected summer daily maximum temperatures, leading to lower heat wave intensity and duration projections. High‐resolution dynamical downscaling simulations reveal strong dependency of changes in event duration and intensity on geographical location and urban density. Event intensity changes are expected to be highest closer to the coast, where afternoon sea‐breezes have traditionally mitigated summer high temperatures. Meanwhile, event duration anomaly is largest over Manhattan, where the urban canopy is denser and taller.
Unbounded Loss in Writing on Dirty Paper is Possible

For a generalization of Costa’s writing on dirty paper with irregular additive noise distribution, we show that the loss between the zerointerference capacity and the causal side information capacity can be arbitrarily large. This contrasts to the Gaussian noise case, where the capacity loss is zero or at most 1/4 bit for the non-causal and causal side information cases, respectively. This also contrasts to the bounded loss in the “dual” problem of rate distortion with side information.
Effect of parity on fetal and maternal microchimerism: interaction of grafts within a host?

Small amounts of genetically foreign cells (microchimerism, Mc) traffic between a mother and fetus during pregnancy. Commonly, these grafts durably persist. For women, multiple naturally acquired Mc grafts can accrue, as they harbor Mc from their own mothers (maternal Mc, MMc) and subsequently acquire fetal Mc (FMc) through pregnancy. The nature of interactions between these naturally acquired grafts may inform, and be informed by, observations in transplantation, including the effect of noninherited maternal HLA antigens (NIMA) and double-unit cord blood transplantation (CBT). We asked whether FMc and MMc are impacted by the addition of new grafts as evaluated by increasing parity. Mc was identified by quantitative PCR for a nonshared polymorphism unique to the Mc source. Despite increasing sources of Mc, FMc did not increase with increasing parity. MMc concentration was significantly lower with increasing parity. The odds ratio for detection of MMc for 2 or more births compared with 1 birth was . 11 (95% CI 0.03-0.42, P = .001). These observations suggest that interactions occur among naturally acquired grafts and are of interest in light of recent observations of graft-graft interaction resulting in predominance of 1 unit in double-unit CBT and the correlation of MMc with the NIMA effect.
SUBMILLIMETER OBSERVATIONS OF MILLIMETER BRIGHT GALAXIES DISCOVERED BY THE SOUTH POLE TELESCOPE

We present APEX SABOCA 350 μm and LABOCA 870 μm observations of 11 representative examples of the rare, extremely bright (S1.4 mm > 15 mJy), dust-dominated millimeter-selected galaxies recently discovered by the South Pole Telescope. All 11 sources are robustly detected with LABOCA with 40 mJy < S870 μm < 130 mJy, approximately an order of magnitude higher than the canonical submillimeter galaxy (SMG) population. Six of the sources are also detected by SABOCA at >3σ, with the detections or upper limits providing a key constraint on the shape of the spectral energy distribution (SED) near its peak. We model the SEDs of these galaxies using a simple modified blackbody and perform the same analysis on samples of SMGs of known redshift from the literature. These calibration samples inform the distribution of dust temperature for similar SMG populations, and this dust temperature prior allows us to derive photometric redshift estimates and far-infrared luminosities for the sources. We find a median redshift of , higher than the inferred for the normal SMG population. We also derive the apparent size of the sources from the temperature and apparent luminosity, finding them to appear larger than our unlensed calibration sample, which supports the idea that these sources are gravitationally magnified by massive structures along the line of sight.
Combined inhibition of AXL, Lyn and p130Cas kinases block migration of triple negative breast cancer cells

Blocking the migration of metastatic cancer cells is a major goal in the therapy of cancer. The receptor tyrosine kinase AXL is one of the main triggers for cancer cell migration in neoplasia of breast, colon, skin, thyroid and prostate. In our study we analyzed the effect of AXL inhibition on cell motility and viability in triple negative breast cancer cell lines overexpressing AXL. Thereby we reveal that the compound BMS777607, exhibiting the lowest IC50 values for inhibition of AXL kinase activity in the studied cell lines, attenuates cell motility to a lower extent than the kinase inhibitors MPCD84111 and SKI606. By analyzing the target kinases of MPCD84111 and SKI606 with kinase profiling assays we identified Lyn, a Src family kinase, as a target of both compounds. Knockdown of Lyn and the migration-related CRK-associated substrate (p130Cas), had a significant inhibitory effect on cell migration. Taken together, our findings highlight the importance of combinatorial or multikinase inhibition of non-receptor tyrosine kinases and AXL receptor tyrosine kinase in the therapy of triple negative breast cancer.
Platelet-Rich Fibrin as a New Approach in Treating Gingival Recession: Systematic Review and Meta-Analysis

The purpose was to systematically review the effect of platelet rich fibrin (PRF) in the treatment of Miller class I and II recession defects in comparison to conventional surgical procedures. Three electronic databases were searched, and hand search was performed for relevant articles, up to October 2015. All relevant articles were independently screened to specific inclusion criteria. Primary outcomes were Recession Depth (RD), Keratinized Tissue Width (KTW), and Percentage of Root Coverage (%RC). Secondary outcomes were Clinical Attachment Level (CAL), Probing Depth (PD), Healing Index (HI), and Pain. Ten randomized clinical trials met the inclusion criteria and seven were included in the meta-analysis. No statistically significant difference was found in %RC between Coronally Advanced Flap (CAF) and CAF + PRF or between CAF + Connective Tissue Graft (CAF + CTG) and CAF + PRF (p = 0.17 and p = 0.56) respectively. A borderline statistical difference was observed between CAF and CAF + PRF (p = 0.05), and no statistically significance difference between CAF + CTG and CAF + PRF (p = 0.23) in KTW. In regards to pain and healing, a significant reduction in pain during the first 5-7 days and faster healing observed in the PRF intervention when compared to the use of CTG or Enamel Matrix Derivative (EMD). In conclusion, there was no statistical or clinical difference present between PRF and CAF, CAF + CTG, or CAF + EMD for RD, %RC and KTW when treating Miller class I and II gingival recession. Significant improvement of postoperative pain and healing can be achieved, which may indicate PRF use as an alternative to conventional surgical approaches.
Non-fatal repetition of self-harm: population-based prospective cohort study in Taiwan

Background Repeated self-harm is relatively common and is linked with an elevated risk of eventual suicide. There has been no study of this involving a large sample from the Far East. Aims To estimate the risk over the medium term of non-fatal repetition of self-harm and identify predictive factors in those carrying out self-harm. Method A total of 970 individuals who had self-harmed were recruited from a community-based suicide behaviour register system in Nantou, Taiwan from July 2000 to February 2003. Information regarding demography and suicide methods was collected. Individuals were followed-up until December 2005 to examine the risk of repeated self-harm and independent predictive factors. Results Ninety cohort members had repeated self-harm during the follow-up period (accounting for 131 repeated self-harm episodes in all). The cumulative risks were 5.7% for the first year, 7.8% for the second year and 9.5% for the fourth year. The risk was highest within the first year after the self-harm event. Independent risk factors included female gender and self-cutting as well as self-poisoning with drugs. Effect of younger age was mediated through the choice of methods. Conclusions Individuals with self-harm have a high risk of repetition, especially within the first year. Suicide prevention strategies need to focus on intervening with this population to reduce their repetition.
Parental involvement to parental engagement: a continuum

Based on the literature of the field, this article traces a continuum between parental involvement with schools, and parental engagement with children’s learning. The article seeks to shed light on an area of confusion; previous research has shown that different stakeholder groups understand “parental engagement” in different ways. Other literature makes it clear that the greatest benefit is derived from the furthest end of the proposed continuum, that is, parental engagement with children’s learning. The continuum gives examples of each stage of the movement along the continuum. The continuum is illustrated not only in prose but as a diagram. The article concludes with a discussion of the agency of parents and schools in the movement along the continuum.
Effect of sulforaphane on micronucleus induction in cultured human lymphocytes by four different mutagens

Isothiocyanates (ITCs) are commonly found in cruciferous vegetables. A variety of biological activities have been ascribed to ITCs, such as inhibition of cytochrome P450 enzymes and induction of phase II enzymes in animal models. ITCs are also able to block cell‐cycle progression and induce apoptosis in human cancer cells in vitro. In this study, we evaluated the ability of the ITC sulforaphane to protect cultured human lymphocytes from micronucleus (MN) induction by four different mutagens: ethyl methanesulfonate (EMS), vincristrine (VIN), H2O2 and mitomycin C (MMC). To understand the mechanisms of action of sulforaphane, the cultures were treated with the compound before, during and after treatment with the mutagens; in addition, the cultures were evaluated for the induction of apoptosis. Up to 10 μM, sulforaphane was non‐genotoxic by itself, while 30 μM sulforaphane reduced the replicative index of the cells by more than 60%. Moreover, 1–10 μM sulforaphane reduced the MN frequency induced by EMS, VIN, H2O2 and MMC in at least one of the treatment protocols; it had no effect on H2O2–MN induction in the post‐treatment protocol, and it increased MN induction by MMC in the pre‐treatment protocol. Apoptosis was produced in the cultures treated with sulforaphane alone. The fraction of apoptotic cells was increased after co‐ or post‐treatment with sulforaphane and EMS and MMC, suggesting that sulforaphane‐mediated apoptosis may remove highly damaged cells induced by these agents. Other mechanisms are involved in the anti‐genotoxic activity of sulforaphane against VIN and H2O2. Taken together, our findings indicate that under certain conditions sulforaphane possesses anti‐genotoxic activity in vitro and that further studies are warranted to characterize this property in vivo. Environ. Mol. Mutagen. , 2005. © 2005 Wiley‐Liss, Inc.
The Malleability of Intellectual Styles: Empirical Evidence: Longitudinal Studies

Intellectual styles are individuals’ preferred ways of using the abilities that they possess. The extent to which one can change his or her intellectual style is a question of interest to both researchers and the general public. This book presents the first comprehensive and systematic review of existing research on the malleability of intellectual styles. By critically analyzing research findings derived from both cross-sectional and longitudinal investigations performed over the past seven decades, Li-fang Zhang demonstrates that intellectual styles can be modified through both socialization and purposeful training. Professor Zhang elucidates the heuristic value of these findings for the development of adaptive intellectual styles in both academic and nonacademic settings. She proposes further avenues of research that might advance scholarly understanding of the nature of and the potential for modifying intellectual styles.
Development of broad spectrum of tumors by ethylnitrosourea in mice and the modifying role of age, sex, and strain.

Summary The modifying role of age, sex, and strain upon the incidence, multiplicity, and spectrum of tumors induced by ethylnitrosourea, a short-acting carcinogen, has been studied. The first-generation (F 1 ) hybrids of C57BL/6J × C3HeB/FeJ and C3HeB/FeJ × A/J mice of both sexes were given single i.p. injections (60 or 120 µg/g) of ethylnitrosourea at 1, 15, or 42 days of age. Experimental animals were left to live their life-span, while the control groups were killed at 52, 90, 142, and 170 weeks of age, respectively. Animals treated with ethylnitrosourea died, in general, by the 90th week of age due to development of tumors mainly in lung, liver, Harderian glands, stomach, ovaries, lymphoreticular system, kidneys, mammary gland, uterus, and nervous system. In contrast, few of the controls died during that same observational period. The age of mice at the time of exposure to the carcinogen was one of the most important modifiers of tumor development in lung, liver, Harderian glands, stomach, kidneys, lymphoreticular system, nervous system, ovaries, and mammary glands. The sex of the animals influenced the development of liver tumors, Harderian gland tumors, and malignant lymphomas. The C3HeB/FeJ × A/J F 1 hybrids more readily developed lung tumors, while the C57BL/6 × C3HeB/FeJ F 1 mice were more susceptible to liver, Harderian gland, lymphoreticular system, ovarian, and mammary gland carcinogenesis.
Antecedents and determinants of high-tech SMEs’ commercialisation enablers: opening the black box of open innovation practices

Abstract Innovation activities have become globalised and open in ways that were unimaginable 20 years ago. These changes have brought new insight into research on innovation activities and specific innovation practices in organisations, including that previous research largely ignored small and medium-sized enterprises (SMEs). This paper tests a variance-based structural equation model (SEM) for selected antecedents and determinants of commercialisation enablers on a sample of 105 SMEs from Slovenia – a small, open, post-transition economy with a dominant SME sector. The main contribution of the paper lies in testing how two specific open innovation practices (open innovation information exchange and open innovation collaboration) impact the commercialisation enablers of high-tech SMEs through their innovation activities (antecedent) and their innovativeness (determinant). Both open innovation practices show statistically significant effect on high-tech SMEs’ innovativeness, thus supporting the idea that both collaboration and information exchange lead to more innovativeness in high-tech SMEs. They also show a high impact of internal (organisational) factors on innovation activities of and a high impact of innovativeness on the commercialisation enablers of high-tech SMEs.