Miracle-dz/UniFAR-FTUs huggingface dataset:
Antibodies to vascular endothelial growth factor enhance the efficacy of cancer immunotherapy by improving endogenous dendritic cell function.

Inadequate function of dendritic cells (DCs) in tumor-bearing hosts is one mechanism of tumor escape from immune system control and may compromise the efficacy of cancer immunotherapy. Vascular endothelial growth factor (VEGF), produced by most tumors, not only plays an important role in tumor angiogenesis but also can inhibit the maturation of DCs from hematopoietic progenitors. Here, we investigate a novel combination of antiangiogenic and immunotherapy based on this dual role of VEGF. Two s.c. mouse tumor models were used: D459 cells, expressing mutant human p53; and MethA sarcoma with point mutations in the endogenous murine p53 gene. Therapy with anti-mouse VEGF antibody (10 microg i.p. twice a week over 4 weeks) was initiated when tumors became palpable. Treatment of established tumors with anti-VEGF antibody alone did not affect the rate of tumor growth. However, anti-VEGF antibody significantly improved the number and function of lymph node and spleen DCs in these tumor-bearing animals. To investigate the possible effects of this antibody on the immunotherapy of established tumors, tumor-bearing mice were immunized with DCs pulsed with the corresponding mutation-specific p53 peptides, together with injections of anti-VEGF antibody. Therapy with peptide-pulsed DCs alone resulted in considerable slowing of tumor growth but only during the period of treatment, and tumor growth resumed after the end of the therapy. Combined treatment with peptide-pulsed DCs and anti-VEGF antibody resulted in a prolonged and much more pronounced antitumor effect. This effect was associated with the induction of significant anti-p53 CTL responses only in this group of mice. These data suggest that inhibition of VEGF may be a valuable adjuvant in the immunotherapy of cancer.
Probiotics and prebiotics to combat enteric infections and HIV in the developing world: a consensus report

Infectious disease in the developing world continues to represent one of the greatest challenges facing humanity. Every year over a million children suffer and die from the sequela of enteric infections, while in 2008 it is estimated almost 2.7 million (UNAIDS 2009 update) adults and children became infected with human immunodeficiency virus (HIV). While oral rehydration therapy for diarrhea, and antiretrovirals (ARV) for HIV are critical, there is a place for adjunctive therapies to improve quality of life. The importance of the human microbiota in retaining health is now recognized, as is the concept of replenishing beneficial microbes through probiotic treatments. Studies have shown that probiotics can reduce the duration of diarrhea, improve gut barrier function, help prevent bacterial vaginosis (BV), and enhance immunity even in HIV-infected subjects. However, many issues remain before the extent of probiotic benefits can be verified, and their application to the developing world realised. This consensus report outlines the potential probiotic, and to a lesser extent prebiotic, applications in resource disadvantages settings, and recommends steps that could bring tangible relief to millions of people. The challenges to both efficacy and effectiveness studies in these settings include a lack of infrastructure and funding for scientists, students and research projects in developing countries; making available clinically proven probiotic and prebiotic products at affordable prices; and undertaking appropriately designed clinical trials. We present a roadmap on how efficacy studies may be conducted in a resource disadvantages setting among persons with chronic diarrhea and HIV. These examples and the translation of efficacy into effectiveness are described.
Importance Weighted Autoencoders

The variational autoencoder (VAE; Kingma, Welling (2014)) is a recently proposed generative model pairing a top-down generative network with a bottom-up recognition network which approximates posterior inference. It typically makes strong assumptions about posterior inference, for instance that the posterior distribution is approximately factorial, and that its parameters can be approximated with nonlinear regression from the observations. As we show empirically, the VAE objective can lead to overly simplified representations which fail to use the network's entire modeling capacity. We present the importance weighted autoencoder (IWAE), a generative model with the same architecture as the VAE, but which uses a strictly tighter log-likelihood lower bound derived from importance weighting. In the IWAE, the recognition network uses multiple samples to approximate the posterior, giving it increased flexibility to model complex posteriors which do not fit the VAE modeling assumptions. We show empirically that IWAEs learn richer latent space representations than VAEs, leading to improved test log-likelihood on density estimation benchmarks.
Contribution of Developmental Assets to the Prediction of Thriving Among Adolescents

This article investigated the contribution of developmental assets to the prediction of thriving behaviors among adolescents. The study was based on a sample of 6,000 youth in Grades 6-12 evenly distributed across 6 ethnic groups. Investigated were the effects of gender, grade, and levels of youth assets on 7 thriving indicators: school success, leadership, valuing diversity, physical health, helping others, delay of gratification, and overcoming adversity. Developmental assets are identified that together contribute "over and above demographic variables" between 10% and 43% to the variance of the thriving indicators and between 47% and 54% of the variance in a composite index comprised of the separate thriving indicators. The results substantially reflect the relation of developmental assets and thriving outcomes suggested by the research literature, and provide evidence for the utility of the developmental assets framework.
Hostility in Employed Women

Ninety-one women employed full-time outside the home were administered the Cook-Medley Hostility Scale. Information concerning various work -and nonwork-related variables was obtained by questionnaire and interview. Women with higher hostility scores reported having more stressful job experiences and feeling more daily stress and tension. Hostility scores were not found to be significantly related to stressful marital experiences or quality of general social support, although there were trends for hostility scores to be negatively related to social support from specific sources-namely, the women's supervisors and husbands. Finally, higher hostility scores were found to be related to greater outward expression of anger. The possibility is mentioned that having more stressful work and other daily experiences may contribute to mediating the relation between the Cook-Medley Hostility Scale and coronary artery disease in women.
Benefits of choral singing for social and mental wellbeing: qualitative findings from a cross‐national survey of choir members

Purpose – The aim of this study is to explore the benefits of choral singing for mental wellbeing and health as perceived by a cross-national sample of amateur choral singers. Design/methodology/approach – Data consisted of written responses to open-ended questions. These were derived from 169 participants selected from a larger dataset reporting high and low levels of emotional wellbeing on the WHOQOL-BREF questionnaire. A majority of participants were female and aged over 50. A thematic analysis was followed by a content analysis and Pearson chi square analyses. Comparisons were made between different ages, genders and nationalities and participants with high and low reported emotional wellbeing. Findings – The analysis revealed multiple themes covering perceived benefits in social, emotional, physical, and cognitive domains. There were no significant differences in frequency of themes across any of the participant sociodemographic and wellbeing categories. The results indicate that benefits of singing may be experienced similarly irrespective of age, gender, nationality or wellbeing status. Research limitations/implications – Implications for further research include future use of validated instruments to measure outcomes and research into the benefits of singing in other cultures. The results of this study suggest that choral singing could be used to promote mental health and treat mental illness. Originality/value – This study examines a cross-national sample which is larger than previous studies in this area. These findings contribute to understanding of the complex and interacting factors which might contribute to wellbeing and health, as well as specific benefits of singing.
Tectonic history of northern New Caledonia Basin from deep offshore seismic reflection: Relation to late Eocene obduction in New Caledonia, southwest Pacific

New, high‐quality multichannel seismic reflection data from the western New Caledonia offshore domain allow for the first time the direct, continuous connection of seismic reflectors between the Deep Sea Drilling Project 208 drill hole on the Lord Howe Rise and the New Caledonia Basin. A novel seismic interpretation is hence proposed for the northern New Caledonia Basin stratigraphy, which places the Eocene/Oligocene unconformity deeper than previously thought and revisits the actual thickness of the pre‐Oligocene sequences. A causal link is proposed between the obduction of the South Loyalty Basin over New Caledonia (NC) and the tectonic history of the northern New Caledonia Basin. Here it is suggested that as the South Loyalty Basin was being obducted during early Oligocene times, the NC Basin subsided under the effect of the overloading and underthrusted to accommodate the compressional deformation, which resulted in (1) the uplift of the northern Fairway Ridge and (2) the sinking of the western flank of New Caledonia. This event also had repercussions farther west with the incipient subsidence of the Lord Howe Rise.
The Effect of Soft Tissue Infections on Device Performance in Adult Cochlear Implant Recipients.

OBJECTIVE The aim of this study was to examine the effect of cochlear implant (CI) site infection and its subsequent management on CI mapping and CI performance. Risk factors for CI infections and pathogens causing infections were reviewed. Treatment options for CI infections were examined. STUDY DESIGN Retrospective case review. SETTING Tertiary referral center. PATIENTS Adult patients with a significant CI soft tissue infection from the Northern Cochlear Implant Programme, New Zealand over a 10-year period (August 2004 until August 2014). INTERVENTION Patients were treated with intravenous antibiotics, washout and debridement or ex-plantation and reimplantation of CI. MAIN OUTCOME MEASURE CI mapping results and implant performance before and after management of CI infections were compared. RESULTS There were nine CI infections. Most patients (7/9) were treated with washout and debridement. One patient required removal of the CI and one patient was deemed medically unfit for a general anaesthetic and was managed conservatively with antibiotics alone. Seven patients received long-term antibiotics. Four patients were able to maintain CI performance after salvage treatment of the CI infection. Three patients had poorer CI performance after salvage treatment. One patient had reimplantation and became a nonuser due to only partial reinsertion. CONCLUSION The pathophysiology of CI infections is complex. Infections can occur many years after CI surgery. The most common bacteria identified were Staphylococcus aureus, Pseudomonas aeruginosa, and skin commensals. Biofilms are present around implants that are removed from patients and biofilms may play a role in CI infections, but the mechanism of infection is not clear.
Beliefs, Attitudes, and Intentions toward Nuclear Energy before and after Chernobyl in a Longitudinal within-subjects Design

Beliefs, attitudes, and behavioral intentions toward nuclear energy in the Netherlands were investigated within a sample of Dutch citizens two months before the Chernobyl accident, one month after the accident, six months after the accident, and one year and seven months after the accident. One month after the accident, analyses revealed more unfavorable attitudes which became less antinuclear five months later. At the end of 1987, attitudes were more antinuclear than ever before. Only a weak relationship was found between self-reported and observed attitude change. After the Chernobyl accident, subjective probabilities of the occurrence of catastrophic accidents in Dutch nuclear power plants were judged far higher than before the accident. From the Chernobyl accident up to the end of 1987, a linear trend upward in these subjective probabilities was observed. Perceived benefits did not change immediately after the accident, but were judged as less probable over time. Subjective probabilities of catastrophic nuclear accidents appeared to correlate more strongly with the attitude toward nuclear energy over time. The results underline the predominance of the perceived catastrophality of consequences attributed to nuclear energy in the public's perception and evaluation of this technology.
Insights from Genomics into Bacterial Pathogen Populations

Bacterial pathogens impose a heavy burden of disease on human populations worldwide. The gravest threats are posed by highly virulent respiratory pathogens, enteric pathogens, and HIV-associated infections. Tuberculosis alone is responsible for the deaths of 1.5 million people annually. Treatment options for bacterial pathogens are being steadily eroded by the evolution and spread of drug resistance. However, population-level whole genome sequencing offers new hope in the fight against pathogenic bacteria. By providing insights into bacterial evolution and disease etiology, these approaches pave the way for novel interventions and therapeutic targets. Sequencing populations of bacteria across the whole genome provides unprecedented resolution to investigate (i) within-host evolution, (ii) transmission history, and (iii) population structure. Moreover, advances in rapid benchtop sequencing herald a new era of real-time genomics in which sequencing and analysis can be deployed within hours in response to rapidly changing public health emergencies. The purpose of this review is to highlight the transformative effect of population genomics on bacteriology, and to consider the prospects for answering abiding questions such as why bacteria cause disease.
A Modified Mualem–van Genuchten Formulation for Improved Description of the Hydraulic Conductivity Near Saturation

The unsaturated soil hydraulic properties are often described using Mualem–van Genuchten (MVG) type analytical functions. Recent studies suggest several shortcomings of these functions near saturation, notably the lack of second‐order continuity of the soil water retention function at saturation and the inability of the hydraulic conductivity function to account for macroporosity. We present a modified MVG formulation that improves the description of the hydraulic conductivity near saturation. The modified model introduces a small but constant air‐entry pressure (hs) into the water retention curve. Analysis of the UNSODA soil hydraulic database revealed an optimal value of −4 cm for hs, more or less independent of soil texture. The modified model uses a pressure dependent piece‐wise linear correction to ensure that deviations between measured and fitted conductivities between pressure heads of 0 and −40 cm were eliminated. A small correction was found necessary between −4 and −40 cm, and a much larger correction was needed between 0 and −4 cm. An average RMSE in logK of only 0.26 remained for a data set of 235 samples. The resulting modified MVG model was found to have small systematic errors across the entire pressure range. The modified model appears well suited for large‐scale vadose zone flow and transport simulations, including inverse modeling studies.
The Influence of Goal Orientation and Risk on Creativity

Employees' creative performance has been found to play a vital role in the continued existence and growth of organizations. Many individual differences (e.g., openness to experience) are significantly related to creative output, but the importance of individuals' goal orientation on creative performance under high or low risk situations has been overlooked. To address this gap in the literature, we studied the relationship between risk and creativity, and investigated whether an individual's goal orientation enhances (i.e., learning orientation) or diminishes (i.e., avoid or prove orientation) the relationship between risk and creative performance. The hypotheses were tested in a laboratory environment using undergraduate subjects. Results showed a positive relationship between risk and creativity. The findings also supported the idea that individuals low in avoid orientation cultivate more creative outputs under high rather than low risk conditions. Limitations, future research, and implications are addressed.
Measuring user confidence in smartphone security and privacy

In order to direct and build an effective, secure mobile ecosystem, we must first understand user attitudes toward security and privacy for smartphones and how they may differ from attitudes toward more traditional computing systems. What are users' comfort levels in performing different tasks? How do users select applications? What are their overall perceptions of the platform? This understanding will help inform the design of more secure smartphones that will enable users to safely and confidently benefit from the potential and convenience offered by mobile platforms. To gain insight into user perceptions of smartphone security and installation habits, we conduct a user study involving 60 smartphone users. First, we interview users about their willingness to perform certain tasks on their smartphones to test the hypothesis that people currently avoid using their phones due to privacy and security concerns. Second, we analyze why and how they select applications, which provides information about how users decide to trust applications. Based on our findings, we present recommendations and opportunities for services that will help users safely and confidently use mobile applications and platforms.
Cortical Somatosensory Reorganization in Children with Spastic Cerebral Palsy: A Multimodal Neuroimaging Study

Although cerebral palsy (CP) is among the most common causes of physical disability in early childhood, we know little about the functional and structural changes of this disorder in the developing brain. Here, we investigated with three different neuroimaging modalities [magnetoencephalography (MEG), diffusion tensor imaging (DTI), and resting-state fMRI] whether spastic CP is associated with functional and anatomical abnormalities in the sensorimotor network. Ten children participated in the study: four with diplegic CP (DCP), three with hemiplegic CP (HCP), and three typically developing (TD) children. Somatosensory (SS)-evoked fields (SEFs) were recorded in response to pneumatic stimuli applied to digits D1, D3, and D5 of both hands. Several parameters of water diffusion were calculated from DTI between the thalamus and the pre-central and post-central gyri in both hemispheres. The sensorimotor resting-state networks (RSNs) were examined by using an independent component analysis method. Tactile stimulation of the fingers elicited the first prominent cortical response at ~50 ms, in all except one child, localized over the primary SS cortex (S1). In five CP children, abnormal somatotopic organization was observed in the affected (or more affected) hemisphere. Euclidean distances were markedly different between the two hemispheres in the HCP children, and between DCP and TD children for both hemispheres. DTI analysis revealed decreased fractional anisotropy and increased apparent diffusion coefficient for the thalamocortical pathways in the more affected compared to less affected hemisphere in CP children. Resting-state functional MRI results indicated absent and/or abnormal sensorimotor RSNs for children with HCP and DCP consistent with the severity and location of their lesions. Our findings suggest an abnormal SS processing mechanism in the sensorimotor network of children with CP possibly as a result of diminished thalamocortical projections.
The nature of burnout: a study of the three-factor model of burnout in human service and non-human service samples

The factor structure of the Maslach Burnout Inventory (MBI) in a human service sample (teachers) and non-human service sample (computer company employees) was investigated. Critics of the three-factor model underlying the MBI (Garden, 1987, 1989; Shirom, 1989) have suggested that the exhaustion factor represents the only intrinsic dimension of burnout and that the other dimensions, particularly depersonalization, are artifacts of the human service samples used to generate the original structure. Confirmatory factor analysis of four models of the dimensionality of the MBI offered partial support to the critics by showing that depersonalization indicators do not form a coherent factor in the non-human service sample. However, a coherent lack of personal accomplishment factor was found in the non-human service sample. Results are discussed in the context of the ongoing debate on the nature of burnout.
AC-DIMM: associative computing with STT-MRAM

With technology scaling, on-chip power dissipation and off-chip memory bandwidth have become significant performance bottlenecks in virtually all computer systems, from mobile devices to supercomputers. An effective way of improving performance in the face of bandwidth and power limitations is to rely on associative memory systems. Recent work on a PCM-based, associative TCAM accelerator shows that associative search capability can reduce both off-chip bandwidth demand and overall system energy. Unfortunately, previously proposed resistive TCAM accelerators have limited flexibility: only a restricted (albeit important) class of applications can benefit from a TCAM accelerator, and the implementation is confined to resistive memory technologies with a high dynamic range (RHigh/RLow), such as PCM. This work proposes AC-DIMM, a flexible, high-performance associative compute engine built on a DDR3-compatible memory module. AC-DIMM addresses the limited flexibility of previous resistive TCAM accelerators by combining two powerful capabilities---associative search and processing in memory. Generality is improved by augmenting a TCAM system with a set of integrated, user programmable microcontrollers that operate directly on search results, and by architecting the system such that key-value pairs can be co-located in the same TCAM row. A new, bit-serial TCAM array is proposed, which enables the system to be implemented using STT-MRAM. AC-DIMM achieves a 4.2X speedup and a 6.5X energy reduction over a conventional RAM-based system on a set of 13 evaluated applications.