Miracle-dz/UniFAR-FTUs huggingface dataset:
Association between Dietary Patterns and Atopic Dermatitis in Relation to GSTM1 and GSTT1 Polymorphisms in Young Children

Previous research suggests the association of glutathione S-transferase (GST) gene polymorphisms or diet, but no interactions between these factors in atopic dermatitis (AD). We conducted a community-based case-control study including 194 AD and 244 matched non-AD preschoolers. Glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) present/null genotypes were evaluated uisng a multiplex PCR method. We measured dietary intakes by a validated food frequency questionnaire and constructed three dietary patterns such as “traditional healthy”, “animal foods”, and “sweets” diets. In stratified analyses by GST genotypes, the “traditional healthy” diet and reduced AD showed association only in the GSTM1-present group (odd ratio (OR) 0.31, 95% confidence interval (CI) 0.13–0.75). A similar pattern of the association existed in the combined GSTM1/T1 genotype that indicated the inverse association between the “traditional healthy” diet and AD in the double GSTM1/T1-present genotype group (OR 0.24, 95% CI 0.06–0.93). Results from the multiplicative test analyses showed that the “traditional healthy” diet on reduced AD was significant or borderline significant in the GSTM1-present group (OR 0.71, 95% CI 0.54–0.92 vs. GSTM1-null group) or the GSTM1/T1 double present group (OR 0.63, 95% CI 0.39–1.03 vs. GSTM1/T1 double null group). These findings demonstrate that the present type of GSTM1 may increase susceptibility to the potential effect of the “traditional healthy” diet on AD.
Crustal field recovery and secular variation from regional and global models over Albania

The static geomagnetic field of crustal origin is optionally calculated bythe recent global geomagnetic field models. However, their description in global scale tends to miss some local characteristics. The same can be inferred for the rate of the geomagnetic field changes i.e. secular variation (SV). In order to depict some particularity of crustal field in local scale for small region like as Albania, two regional models are constructed: one based on the Legendre’s polynomials and the other based on a linear approximation. Both models use data from different measurement campaigns in the Albanian repeat stations and few data from neighbourhood countries. The residuals produced by these models and by the recent global models: EMM2015, POMME – 9 and CHAOS-5 are calculated and compared. The SV from regional and global models following standard procedures are also calculated. Substantial differences between SV calculated by global models and regional models are observed.
One-Level Phonology: Autosegmental Representations and Rules as Finite Automata

When phonological rules are regarded as declarative descriptions, it is possible to construct a model of phonology in which rules and representations are no longer distinguished and such procedural devices as rule-ordering are absent. In this paper we present a finite-state model of phonology in which automata are the descriptions and tapes (or strings) are the objects being described. This provides the formal semantics for an autosegmental phonology without structure-changing rules. Logical operations on the phonological domain---such as conjunction, disjunction, and negation---make sense since the phonological domain consists of descriptions rather than objects. These operations as applied to automata are the straightforward operations of intersection, union, and complement. If the arrow in a rewrite rule is viewed as logical implication, then a phonological rule can also be represented as an automaton, albeit a less restrictive automaton than would be required for a lexical representaton. The model is then compared with the transducer models for autosegmental phonology of Kay (1987), Kornai (1991), and Wiebe (1992). We conclude that the declarative approach to phonology presents an attractive way of extending finite-state techniques to autosegmental phonology while remaining within the confines of regular grammar.
Impact of the 2009 Influenza (H1N1) Pandemic on the United States Military Health Care System

ABSTRACT Background: During public health emergencies, the Military Health System experiences challenges similar to those across the U.S. public and private health systems. This study explored how 1 such event, the 2009/2010 influenza (H1N1) pandemic, impacted health care utilization and associated costs in the Military Health System. Methods: Data from the Military Data Repository were used to examine diagnoses, claims data, and dates of services with respect to military or civilian care during 2004–2009/2010 influenza seasons. Comparison analysis was conducted through two-tailed t-tests and regression models. Results: There was a significant increase in inpatient and outpatient health care utilization during the 2009/2010 H1N1 pandemic year, most markedly for emergency department visits. The 2009/2010 H1N1 pandemic cost the Department of Defense $100 million compared to influenza-related health care costs incurred in previous influenza seasons. Highest health care utilization costs were found in children less than age 5. The greatest cost burden was attributed to immunizations for active duty personnel delivered at military facilities. Conclusion: Annual trend analysis of costs and health care utilization would be helpful to plan and resource emerging influenza pandemics and to identify subgroups at greatest risk for contracting influenza.
Characterizing network processing delay

Computer networks have progressed from a simple store-and-forward medium to a complex communication infrastructure. Routers in the network need to implement a variety of functions ranging from simple packet classification for forwarding and firewalling to complex payload modifications for encryption and content adaptation. As these functions increase in number and complexity, more processing time is required, and packets experience a significant processing delay. In most network simulations, this delay has not been addressed because it was considered negligible. However, we show that this network processing delay can reach the magnitude of long-distance propagation delay and thus becomes a significant contributor to the overall packet delay. We evaluate different network applications and develop a model that characterizes packet processing cost with only a few parameters that can easily be derived from our simulations. To validate our simulation and our model, we compare them to actual network measurements. The contributions of this work can be used to increase the accuracy of network simulations and improve network performance estimations.
Employee Reactions and Adjustment to Euthanasia-Related Work: Identifying Turning-Point Events Through Retrospective Narratives

This study used a retrospective narrative procedure to examine the critical events that influence reactions and adjustment to euthanasia-related work of 35 employees who have stayed in the animal care and welfare field for at least 2 years. The study analyzed adjustment trajectory graphs and interview notes to identify turning-point events that spurred either a positive or negative change in shelter workers' psychological well-being. Analysis of the identified turning-point events revealed 10 common event themes that have implications for a range of work, personnel, and organizational practices. The article discusses implications for shelter, employee, and animal welfare.
Carbon Dioxide Exchange Between Atmosphere and Ocean and the Question of an Increase of Atmospheric CO2 during the Past Decades

From a comparison of C 14 /C 12 and C 13 /C 12 ratios in wood and in marine material and from a slight decrease of the C 14 concentration in terrestrial plants over the past 50 years it can be concluded that the average lifetime of a CO 2 molecule in the atmosphere before it is dissolved into the sea is of the order of 10 years. This means that most of the CO 2 released by artificial fuel combustion since the beginning of the industrial revolution must have been absorbed by the oceans. The increase of atmospheric CO 2 from this cause is at present small but may become significant during future decades if industrial fuel combustion continues to rise exponentially. Present data on the total amount of CO 2 in the atmosphere, on the rates and mechanisms of exchange, and on possible fluctuations in terrestrial and marine organic carbon, are inadequate for accurate measurement of future changes in atmospheric CO 2 . An opportunity exists during the International Geophysical Year to obtain much of the necessary information. DOI: 10.1111/j.2153-3490.1957. tb01849.x
Effects of Blood Transportation on Human Peripheral Mononuclear Cell Yield, Phenotype and Function: Implications for Immune Cell Biobanking

Human biospecimen collection, processing and preservation are rapidly emerging subjects providing essential support to clinical as well as basic researchers. Unlike collection of other biospecimens (e.g. DNA and serum), biobanking of viable immune cells, such as peripheral blood mononuclear cells (PBMC) and/or isolated immune cell subsets is still in its infancy. While certain aspects of processing and freezing conditions have been studied in the past years, little is known about the effect of blood transportation on immune cell survival, phenotype and specific functions. However, especially for multicentric and cooperative projects it is vital to precisely know those effects. In this study we investigated the effect of blood shipping and pre-processing delay on immune cell phenotype and function both on cellular and subcellular levels. Peripheral blood was collected from healthy volunteers (n = 9): at a distal location (shipped overnight) and in the central laboratory (processed immediately). PBMC were processed in the central laboratory and analyzed post-cryopreservation. We analyzed yield, major immune subset distribution, proliferative capacity of T cells, cytokine pattern and T-cell receptor signal transduction. Results show that overnight transportation of blood samples does not globally compromise T- cell subsets as they largely retain their phenotype and proliferative capacity. However, NK and B cell frequencies, the production of certain PBMC-derived cytokines and IL-6 mediated cytokine signaling pathway are altered due to transportation. Various control experiments have been carried out to compare issues related to shipping versus pre-processing delay on site. Our results suggest the implementation of appropriate controls when using multicenter logistics for blood transportation aiming at subsequent isolation of viable immune cells, e.g. in multicenter clinical trials or studies analyzing immune cells/subsets. One important conclusion might be that despite changes due to overnight shipment, highly standardized central processing (and analysis) could be superior to multicentric de-central processing with more difficult standardization.
A newly discovered bacterium associated with parthenogenesis and a change in host selection behavior in parasitoid wasps

The symbiotic bacterium Wolbachia pipientis has been considered unique in its ability to cause multiple reproductive anomalies in its arthropod hosts. Here we report that an undescribed bacterium is vertically transmitted and associated with thelytokous parthenogenetic reproduction in Encarsia, a genus of parasitoid wasps. Although Wolbachia was found in only one of seven parthenogenetic Encarsia populations examined, the “Encarsia bacterium” (EB) was found in the other six. Among seven sexually reproducing populations screened, EB was present in one, and none harbored Wolbachia. Antibiotic treatment did not induce male production in Encarsia pergandiella but changed the oviposition behavior of females. Cured females accepted one host type at the same rate as control females but parasitized significantly fewer of the other host type. Phylogenetic analysis based on the 16S rDNA gene sequence places the EB in a unique clade within the Cytophaga-Flexibacter-Bacteroid group and shows EB is unrelated to the Proteobacteria, where Wolbachia and most other insect symbionts are found. These results imply evolution of the induction of parthenogenesis in a lineage other than Wolbachia. Importantly, these results also suggest that EB may modify the behavior of its wasp carrier in a way that enhances its transmission.
Presentation, management, and outcomes of 25 748 acute coronary syndrome admissions in Kerala, India: results from the Kerala ACS Registry.

AIMS There are limited contemporary data on the presentation, management, and outcomes of acute coronary syndrome (ACS) admissions in India. We aimed to develop a prospective registry to address treatment and health systems gaps in the management of ACSs in Kerala, India. METHODS AND RESULTS We prospectively collected data on 25 748 consecutive ACS admissions from 2007 to 2009 in 125 hospitals in Kerala. We evaluated data on presentation, management, and in-hospital mortality and major adverse cardiovascular events (MACE). We created random-effects multivariate regression models to evaluate predictors of outcomes while accounting for confounders. Mean (SD) age at presentation was 60 (12) years and did not differ among ACS types [ST-segment myocardial infarction (STEMI) = 37%; non-STEMI = 31%; unstable angina = 32%]. In-hospital anti-platelet use was high (>90%). Thrombolytics were used in 41% of STEMI, 19% of non-STEMI, and 11% of unstable angina admissions. Percutaneous coronary intervention rates were marginally higher in STEMI admissions. Discharge medication rates were variable and generally suboptimal (<80%). In-hospital mortality and MACE rates were highest for STEMI (8.2 and 10.3%, respectively). After adjustment, STEMI diagnosis (vs. unstable angina) [odds ratio (OR) (95% confidence interval = 4.06 (2.36, 7.00)], symptom-to-door time >6 h [OR = 2.29 (1.73, 3.02)], and inappropriate use of thrombolysis [OR = 1.33 (0.92, 1.91)] were associated with higher risk of in-hospital mortality and door-to-needle time <30 min [OR = 0.44 (0.27, 0.72)] was associated with lower mortality. Similar trends were seen for risk of MACE. CONCLUSION These data represent the largest ACS registry in India and demonstrate opportunities for improving ACS care.
DNA-binding proteins induced by herpes simplex virus type 2 in HEp-2 cells

Affinity chromatography on single-stranded and double-stranded DNA-cellulose indicates that 12 proteins previously identified from herpes simplex virus type 2-infected cells, ranging in molecular weight from 28 X 10(3) to 186 X 10(3), bind to DNA-cellulose. The DNA-binding proteins found in infected cells differed in relative binding strengths for denatured DNA-cellulose. The virus specificity of these DNA-binding proteins was further studied by comparison with DNA-binding proteins isolated from mock-infected cells, and by immunoprecipitation of infected-cell DNA-binding proteins with antisera specific for viral antigens. The promise this technique holds for the purification and study of polypeptides involved in virus DNA replication, recombination, or repair is discussed.
Niche of harmful alga Aureococcus anophagefferens revealed through ecogenomics

Harmful algal blooms (HABs) cause significant economic and ecological damage worldwide. Despite considerable efforts, a comprehensive understanding of the factors that promote these blooms has been lacking, because the biochemical pathways that facilitate their dominance relative to other phytoplankton within specific environments have not been identified. Here, biogeochemical measurements showed that the harmful alga Aureococcus anophagefferens outcompeted co-occurring phytoplankton in estuaries with elevated levels of dissolved organic matter and turbidity and low levels of dissolved inorganic nitrogen. We subsequently sequenced the genome of A. anophagefferens and compared its gene complement with those of six competing phytoplankton species identified through metaproteomics. Using an ecogenomic approach, we specifically focused on gene sets that may facilitate dominance within the environmental conditions present during blooms. A. anophagefferens possesses a larger genome (56 Mbp) and has more genes involved in light harvesting, organic carbon and nitrogen use, and encoding selenium- and metal-requiring enzymes than competing phytoplankton. Genes for the synthesis of microbial deterrents likely permit the proliferation of this species, with reduced mortality losses during blooms. Collectively, these findings suggest that anthropogenic activities resulting in elevated levels of turbidity, organic matter, and metals have opened a niche within coastal ecosystems that ideally suits the unique genetic capacity of A. anophagefferens and thus, has facilitated the proliferation of this and potentially other HABs.
Minimization protocols in pancreas transplantation

Diagnosis of immunologic injury (acute and chronic) is much more difficult in pancreas transplants when compared with transplants of other organs. Currently, the immunosuppressive regimen for induction involves calcineurin inhibitors (CNI), antimetabolites and corticosteroids (Cs). This strong and nonspecific regimen does not take into consideration pancreas specificities (i.e. the need to avoid diabetogenic compounds). For obvious reasons, CNI might be calling for review, if permanently indicated in recipients of solitary pancreas with mild renal dysfunction. CNI as well as corticosteroids may induce hyperglycemia and contribute to differential diagnosis of a rejection process. However, in spite of the benefits accruing from withdrawal of above immunosuppressive agents, minimization or avoidance of these drugs could be dangerous and may end up with graft loss (i.e. antibody‐mediated process). Long‐term results of pancreas transplantation are now achieving comparable survival rates similar to the transplant of traditional organs such as kidney and liver. As a consequence, the physicians’ objectives are to prolong the patient’s quality of life and organ function as long as possible. Weaning strategies in regard to CNI and steroids are tested. Sirolimus, everolimus, CTLA‐4 Ig, etc, are agents known to be either both nonnephrotoxic and nondiabetogenic or less so when compared with CNI. Their impact on pancreas transplantation is beginning to be evaluated. Large randomized trials in all pancreas categories, with long‐term clinical and histologic results, are mandatory to establish new guidelines for immunosuppressive regimens for pancreas transplantation.
Advances in Cancer Therapy 346 human head and neck squamous carcinoma cells

Curcumin is a major biological active compound from turmeric or Curcuma longa. This nontoxic natural compound has been reported to possess several biological activities that are therapeutically beneficial to cancer treatment. It has been reported to increase the efficacy of other chemotherapeutic agents and to reduce their toxic side effects which are the major drawback of most chemotherapeutic agents. Curcumin is also well known for its antiinflammatory activity (Amanda and Robert, 2008). Since cancer often develops under chronic inflammatory conditions, curcumin has the potential to be a preventive treatment agent against cancer. Furthermore, unlike most chemotherapeutic agents which act on a specific process of cancer development, i.e., cell growth or apoptosis, curcumin exerts its effect on various stages of cancer development, i.e., oncogene activation (Singh and Singh, 2009), cancer cell proliferation (Simon et al., 1998), apoptosis evasion (Han et al., 1999), anoikis resistance (Pongrakhananon et al., 2010), and metastasis (Chen et al., 2008) (Figure 1). Therefore, curcumin has the potential to overcome chemoresistance which is a major problem in cancer chemotherapy. This chapter will provide an overview of the anticancer activities of curcumin and present pre-clinical and clinical evidence supporting the use of curcumin as an anticancer agent. Cancer is known to be associated with genetic instability in which c-myc serves as a major modifier of many targeted genes (Mai and Mushinski, 2003). Likewise, the mutation of proto-oncogene ras has been identified in many types of tumor (Rajalingam et al., 2007). The dysregulation of these oncogenes is well recognized as an initial step in the development of tumorigenesis. Interestingly, curcumin has been reported to have a suppressive effect on the oncogenes and inhibit their downstream effectors such as cell cycle promoting and proapoptotic proteins (Singh and Singh, 2009). Curcumin also exhibits anticancer properties through its ability to inhibit cell proliferation and induce apoptosis. The anti-proliferative effect of curcumin is dependent on its concentration, duration of treatment, and specific cell type. At low doses, curcumin causes cell cycle arrest, while at higher doses it induces apoptosis. Cell proliferation is controlled by several cell cycle regulating proteins, notably the family of cyclin and cyclin-dependent kinases (Kastan and Bartek, 2004) whose expression is tightly associated with tumorigenesis (Diehl, 2002). Curcumin inhibits cell cycle progression by downregulating cyclin D1 and the transition from G1 to S phase in
Forest Mortality in Lake Tahoe Basin from 1985-2010: Influences of Forest Type, Stand Density, Topography and Climate

i Literature Cited . iii Dedication . vi Acknowledgments . vii Plate 1: Remote sensing derived maps of annual (Fall Year One-Fall Year Two) canopy dieback and healthy pixels in coniferous forests of the Lake Tahoe Basin. High mortality years, 1986-1987 and 1994-1995, occurred around a reported drought period. Lower levels of mortality occurred in a later drought period (2002-2003) with 2009-2010 indicative of more average mortality levels in addition to patches of tree mortality within density reduction treatments.viii Plate 2. Photograph of mountain pine beetle damage in High Meadows area in lodgepole pine forests in southern region of LTB. Figure on right shows 2006-2009 canopy mortality derived from remote sensing imagery classification . ix List of Tables . xiii List of Figures . xiv Chapter 1 – Are Denser Forests Less Healthy: A Remote Sensing Analysis of DensityDependent Forest Mortality . 1 Abstract . 2 Introduction . 2 Methods . 10 Study Area . 10
Cell 2-representations of finitary 2-categories

Abstract We study 2-representations of finitary 2-categories with involution and adjunctions by functors on module categories over finite-dimensional algebras. In particular, we define, construct and describe in detail (right) cell 2-representations inspired by Kazhdan–Lusztig cell modules for Hecke algebras. Under some natural assumptions we show that cell 2-representations are strongly simple and do not depend on the choice of a right cell inside a two-sided cell. This reproves and extends the uniqueness result on categorification of Kazhdan–Lusztig cell modules for Hecke algebras of type A from [V. Mazorchuk and C. Stroppel, Categorification of (induced) cell modules and the rough structure of generalised Verma modules, Adv. Math. 219 (2008), 1363–1426].