Miracle-dz/UniFAR-FTUs huggingface dataset:
Low Interest Rates and Housing Bubbles: Still No Smoking Gun

This paper revisits the relationship between interest rates and house prices. Surveying a number of recent studies and bringing to bear some new evidence on the question, this paper argues that in the data, the impact of interest rates on house prices appears to be quite modest. Specifically, the estimated effects are uniformly smaller than those implied by the conventional user cost theory of house prices, and they are too small to explain the previous decade's real estate boom in the U.S. and elsewhere. However in some countries, there does appear to have been a link between the rapid expansion of the monetary base and growth in house prices and housing credit.
Cytopathogenic mechanisms of Entamoeba histolytica

Cinemicrography of Entamoeba histolytica destruction of Chinese hamster ovary (CHO) cells shows that ameba cytopathogenicity consists of separate components: a contact-dependent cytolethal effect, and phagocytosis. Cells not in contact with amebae remain intact. Quantitation of ameba destruction of CHO cells by applying the one-hit hypothesis confirms that the cytoethal effect of amebae is contact dependent. Studies with 111Indium oxine-labeled cells provide further evidence of extracellular killing by E. histolytica and indicate that > 94% of the target cells are killed before phagocytosis. When we examined for a cytotoxin release by E. histolytica, we found no effect on CHO cells with filtrates of amebae, and a nonspecific effect of cell rounding and release with sonicates of amebae. The ameba sonicate effect was time-dose dependent, was not cytolethal, was reversible, and was inhibited by alpha II macroglobulin. Cytochalasin B altered ameba motility and morphology, and monolayer experiments confirmed that cytochalasins A, B, or D inhibited CHO cell destruction by E. histolytica. Cytochalasin D also inhibited extracellular killing of CHO cells by amebae in pellets, apparently independent of effects on ameba motility or phagocytosis. Colchicine and vinblastine, alone or in combination with cytochalasin D, did not inhibit E. histolytica cytopathogenicity, which indicates that microtubule function is not required for target cell killing by amebae.
A short communication course for physicians improves the quality of patient information in a clinical trial

We investigated whether a short course in communication skills for physicians would improve the quality of informed consent in a randomized clinical adjuvant trial on breast cancer. In this prospective, case-controlled intervention study, physicians and research nurses who introduced the cancer treatment trial to patients at three of the participating hospitals first attended a one-day communication skills course. The quality of informed consent was then evaluated by addressing a standardized questionnaire, QuIC, to trial patients at the three intervention hospitals and at control hospitals. Response rate was 90.0% (n =288). Of the patients treated by the intervention group, 73% were very satisfied with the information received compared with 56% of those of the control group (p = 0.003). The patients of the intervention group considered the time given for making their decision sufficient more often than those of the controls (98% vs. 90%, p=0.004). The patients of the intervention group recalled more often than those of the controls that the physician had also offered other therapeutic options than the trial treatment (91% vs. 97%, p=0.032). They also understood the main aim of the study better than the patients of the controls (89% vs. 78%, p=0.030). In conclusion, a short communication skills course for the trial physicians and nurses improved the quality of informed consent and patient satisfaction in the trial.
Coherent Versus Non-Coherent Decode-and-Forward Relaying Aided Cooperative Space-Time Shift Keying

Motivated by the recent concept of Space-Time Shift Keying (STSK), we propose a novel cooperative STSK family, which is capable of achieving a flexible rate-diversity tradeoff, in the context of cooperative space-time transmissions. More specifically, we first propose a Coherent cooperative STSK (CSTSK) scheme, where each Relay Node (RN) activates Decode and-Forward (DF) transmissions, depending on the success or failure of Cyclic Redundancy Checking (CRC). We invoke a bit to-STSK mapping rule, where according to the input bits, one of the Q pre-assigned dispersion vectors is activated to implicitly convey log2 Q bits, which are transmitted in combination with the classic log2 L-bit modulated symbol. Additionally, we introduce a beneficial dispersion vector design, which enables us to dispense with symbol-level Inter-Relay Synchronization (IRS). Further more, the Destination Node (DN) is capable of jointly detecting the signals received from the source-destination and relay destination links, using a low-complexity single-stream-based Maximum Likelihood (ML) detector, which is an explicit benefit of our Inter-Element Interference (IEI)-free system model. More importantly, as a benefit of its design flexibility, our cooperative CSTSK arrangement enables us to adapt the number of the RNs, the transmission rate as well as the achievable diversity order. Moreover, we also propose a Differentially-encoded cooperative STSK (DSTSK) arrangement, which dispenses with CSI estimation at any of the nodes, while retaining the fundamental benefits of the cooperative CSTSK scheme.
Experiment

A number of common problems plague the teaching of the undergraduate research methods course, from the training ofteaching assistants to providing meaningful experimental materials to handling data acquisition and analysis. The Student Micro Experimental Laboratory (MEL) offers a systematic approach to the management of a computerized research methods laboratory course by combining high-quality experiments in many areas of psychology with background materials to help the instructor and teaching assistant. The software presents and collects data from 28 experiments. The data can be analyzed for single subjects and for classes as a whole. Students can rapidly implement new experiments in a variety ofparadigms. An expanding library of experiments created by students and instructors should provide an expanding environment for teaching experimental research methods. Instructor's materials provide background infor mation, discussion questions, and data analysis for all experiments. The student workbook pro vides discussion ofthe background of the experiment, details of the methodology, and questions addressing various aspects of experimental design and interpretation of data. Several problems are commonly encountered in teach ing the
The expression of slow myosin during mammalian somitogenesis and limb bud differentiation

The developmental pattern of slow myosin expression has been studied in mouse embryos from the somitic stage to the period of secondary fiber formation and in myogenic cells, cultured from the same developmental stages. The results obtained, using a combination of different polyclonal and monoclonal antibodies, indicate that slow myosin is coexpressed in virtually all the cells that express embryonic (fast) myosin in somites and limb buds in vivo as well as in culture. On the contrary fetal or late myoblasts (from 15-d-old embryos) express in culture only embryonic (fast) myosin. At this stage, muscle cells in vivo, as already shown (Crow, M.T., and F.A. Stockdale. 1986. Dev. Biol. 113:238-254; Dhoot, G.K. 1986. Muscle & Nerve. 9:155-164; Draeger, A., A.G. Weeds, and R.B. Fitzsimons. 1987. J. Neurol. Sci. 81:19-43; Miller, J.B., and F.A. Stockdale. 1986. J. Cell Biol. 103:2197-2208), consist of primary myotubes, which express both myosins, and secondary myotubes, which express preferentially embryonic (fast) myosin. Under no circumstance neonatal or adult fast myosins were detected. Western blot analysis confirmed the immunocytochemical data. These results suggest that embryonic myoblasts in mammals are all committed to the mixed embryonic-(fast) slow lineage and, accordingly, all primary fibers express both myosins, whereas fetal myoblasts mostly belong to the embryonic (fast) lineage and likely generate fibers containing only embryonic (fast) myosin. The relationship with current models of avian myogenesis are discussed.
Digital Literacy, Insurtech Adoption and Insurance Inclusion in Uganda

The purpose of this study was to establish whether digital literacy and insurtech adoption influence insurance inclusion in Uganda. Principally, we sought to determine whether insurtech adoption mediates the nexus between digital literacy and insurance inclusion. This study adopted a cross-sectional and quantitative correlational approach. The study’s sample was 391 individuals who had used digital platforms such as mobile phones and computers to access insurance products and services in Uganda. Data were collected using structured survey questionnaires. Partial Least Squares Structural Equation Modelling (PLSEM) was employed to test the hypothesised relationships. The results demonstrated that both digital literacy and insurtech adoption significantly and positively influence insurance inclusion. We also found digital literacy to be a significant and positive determinant of insurtech adoption. Markedly, it was found that insurtech adoption mediates the association between digital literacy and insurance inclusion in Uganda. However, this study was conducted in a developing country with an underdeveloped insurance market and with low technological advancement. This may affect the generalisation of the study’s findings. This study’s novelty lies in establishing how digital literacy and insurtech adoption interact to influence insurance inclusion in Uganda. This is the first study to examine the effect of digital literacy and insurtech adoption on insurance inclusion.
Systematic review of the role of rituximab in treatment of antineutrophil cytoplasmic autoantibody-associated vasculitis, hepatitis C virus-related cryoglobulinemic vasculitis, Henoch–Schönlein purpura, ankylosing spondylitis, and Raynaud’s phenomenon

Rituximab (RTX) is established for the treatment of rheumatoid arthritis. This systematic review of the literature since 2006 summarizes evidence for the use of RTX in the treatment of additional rheumatological diseases: antineutrophil cytoplasmic autoantibody-associated vasculitis (AAV), hepatitis C virus-related cryoglobulinemic vasculitis, Henoch–Schönlein purpura, ankylosing spondylitis, and Raynaud’s phenomenon. Data from randomized controlled trials are available only for AAV, confirming efficacy for remission induction, including in disease resistant to conventional treatment, and maintenance of remission. Further studies are required to confirm optimal maintenance regimens in AAV, important questions needing to be addressed including protocol administration versus treatment in response to clinical relapse and the importance of maintaining B-cell depletion. Sufficient data are available in other diseases to suggest RTX to be useful and that randomized controlled trials should be conducted.
Damping Properties of the Hair Bundle

The viscous liquid surrounding a hair bundle dissipates energy and dampens oscillations, which poses a fundamental physical challenge to the high sensitivity and sharp frequency selectivity of hearing. To identify the mechanical forces at play, we constructed a detailed finite‐element model of the hair bundle. Based on data from the hair bundle of the bullfrog's sacculus, this model treats the interaction of stereocilia both with the surrounding liquid and with the liquid in the narrow gaps between the individual stereocilia. The investigation revealed that grouping stereocilia in a bundle dramatically reduces the total drag. During hair‐bundle deflections, the tip links potentially induce drag by causing small but very dissipative relative motions between stereocilia; this effect is offset by the horizontal top connectors that restrain such relative movements at low frequencies. For higher frequencies the coupling liquid is sufficient to assure that the hair bundle moves as a unit with a low total drag. This work reveals the mechanical characteristics originating from hair‐bundle morphology and shows quantitatively how a hair bundle is adapted for sensitive mechanotransduction.
Two-Year Analysis of Efficacy and Safety of Deferasirox Treatment for Transfusional Iron Overload in Sickle Cell Anemia Patients

The efficacy and safety of a 2-year treatment with deferasirox was evaluated in 31 patients with sickle cell anemia and transfusional iron overload. At 24 months, there were significant decreases from baseline in mean serum ferritin (from 2,344.6 to 1,986.3 µg/l; p = 0.040) and in mean liver iron concentration (from 13.0 ± 5.4 to 9.3 ± 5.7 mg Fe/g dry weight; p < 0.001). Myocardial T2* values were normal (>20 ms) in all patients at baseline and did not change significantly over the course of the study. However, there was a significant improvement from baseline in left ventricular ejection fraction at 24 months (62.2–64.6%; p = 0.02). Deferasirox was generally well tolerated with no progressive increases in serum creatinine or renal failure observed. These data confirm that deferasirox is effective in reducing body iron burden in patients with sickle cell anemia and transfusional iron overload.
Non-Invasive Recording of Ocular-Following Responses in Children: A Promising Tool for Stereo Deficiency Evaluation

Background: The ability to merge the two retinal images to perceive depth (stereopsis) plays an important role in human vision. Its proper development requires binocular alignment and good visual acuity in both eyes during childhood. Because treatments are more effective when applied early, early diagnosis is important. Unfortunately, assessing stereo deficiencies in infants and young children remains challenging. Recently, it has been shown that ocular-following responses (OFRs; reflexive, short-latency eye movements induced by the sudden motion of a large textured pattern) are sensitive to changes in interocular correlation, making them potentially useful for stereo deficiency assessments. To test this hypothesis, we measured OFRs elicited by dichoptic stimulation in children with normal and compromised stereopsis (due to amblyopia). Methods: Two groups of six children (age- and sex-matched: 3M/3F aged 7–12 yo), one with compromised stereopsis and one with normal stereopsis, were included. OFRs were recorded using a custom high-resolution video eye-tracking system. The relative differences between eye displacement induced by correlated stimuli (up-correlated–down-correlated) and anticorrelated (up-anticorrelated–down-anticorrelated) were compared. Results: We found significant differences between OFRs induced by two dichoptic conditions (correlated and anticorrelated stimuli) in most children with normal stereopsis, whereas no differences were observed in children with compromised stereopsis, indicating a lack of disparity detectors. Conclusions: OFRs might thus be exploited as a diagnostic tool for the objective identification of stereo deficiencies in children. This might lead to improved early diagnosis and treatment outcomes for conditions like amblyopia and strabismus.
Therapeutic Impact of Aerobic Exercise on Adolescents with Obesity and Its Association with Expression of miRNAs and Cytokines: A Clinical Approach

Background and Objectives: MicroRNAs are short noncoding RNAs that play an essential role in controlling gene expression at the posttranscriptional level. They can serve as biomarkers in the management of obesity. Circulating miRNAs levels change with exercise, impacting various physiological and biological systems, including structural and functional changes. Aim: The purpose of this study is to evaluate the levels of miRNAs 423-5p and 128-1 in young adolescents with obesity before and after an aerobic exercise programme. We also analyse the relationship between those microRNAs and obesity-related parameters in response to aerobic exercise training. Materials and Methods: A total of 64 adolescent individuals (32 individuals with obesity and 32 healthy individuals) were enrolled in the study to participate in a 6-month aerobic exercise programme. Anthropometric measurements, biochemical parameters and blood samples were collected from all the participants prior to exercise training and after the 6-month programme. Gene expression analysis of the study participants was performed using quantitative real-time PCR. Results: Expression levels of circulating microRNAs 423-5p (p < 0.01) and 128-1 (p < 0.01) differed significantly before and after exercise in the study population. Circulating miRNA 423-5p increased and correlated significantly with BMI while circulating miRNA 128-1 decreased and also significantly correlated with BMI after the 6-month aerobic exercise programme. Logistic regression analysis shows that the elevation in miRNAs expression levels has a strong significant association with the increased levels of the cytokines IL-6 and TNF-α (p < 0.05). Conclusions: Obesity leads to alterations in the expressions of miRNA 423-5p and miRNA 128-1. The significant changes observed after an aerobic exercise programme demonstrate the potential of these miRNAs as diagnostic and prognostic biomarkers for obesity.
Working Papers in Economics and Statistics Uncertainty of Governmental Relief and the Crowding out of Insurance Uncertainty of Governmental Relief and the Crowding out of Insurance

This paper discusses the problem of crowding out of insurance by co-existing governmental relief programs-so-called 'charity hazard'-in a context of different institutional schemes of government relief in Austria and Germany. We test empirically whether an assured partial relief scheme (as in Austria) drives a stronger crowding out of private insurance than a scheme promising full relief which is subject to ad hoc political decision making (as in Germany). Our general finding is that the institutional design of governmental relief programs significantly affects the demand for private natural hazard insurance.
Modeling Two‐Phase Debris Flows With Grain‐Fluid Separation Over Rugged Topography: Application to the 2009 Hsiaolin Event, Taiwan

Landslides or debris flows usually arise in mountainous areas and slide over a rough topography. As the flow body is typically a mixture of particles and interstitial fluid, this paper aims at developing a binary mixture model and its numerical implementation for shallow debris flows on rugged topography. The mathematical formulation of this saturated solid‐fluid mixture is developed with respect to a terrain‐fitted coordinate system. Employing the thin layer assumption, a system of depth‐integrated equations is derived, where the interstitial fluid is supposed to be a viscous Newtonian fluid and the granular material is treated as a frictional Coulomb‐like continuum. At the basal surface, the Coulomb sliding condition for the granular constituent and Navier slip for the fluid phase are applied. The interaction between granular material and interstitial fluid is depicted by the buoyancy and a drag force induced by the velocity difference of both the phases. Numerical investigations are performed for studying the features of the proposed model, where a shock‐capturing nonoscillatory scheme is employed. A thorough parameter study of flows over three idealized terrain geometries illustrates the distinct impacts of the applied material parameters on the flow dynamics and deposit shapes. The phase separation such as the solid‐phase‐dominated flow front and how this changes with parameter values are presented. The simulation of the Hsiaolin landslide successfully retraces the approximate flow path recognized in satellite images as well as the measured deposition given in Kuo et al. (2011, https://doi.org/10.1029/2010JF001921).
Distinct Iron Binding Property of Two Putative Iron Donors for the Iron-Sulfur Cluster Assembly

Frataxin, a small mitochondrial protein linked to the neurodegenerative disease Friedreich ataxia, has recently been proposed as an iron donor for the iron-sulfur cluster assembly. An analogous function has also been attributed to IscA, a key member of the iron-sulfur cluster assembly machinery found in bacteria, yeast, and humans. Here we have compared the iron binding property of IscA and the frataxin ortholog CyaY from Escherichia coli under physiological and oxidative stress conditions. In the presence of the thioredoxin reductase system, which emulates the intracellular redox potential, CyaY fails to bind any iron even at a 10-fold excess of iron in the incubation solution. Under the same physiologically relevant conditions, IscA efficiently recruits iron and transfers the iron for the iron-sulfur cluster assembly in a proposed scaffold IscU. In the presence of hydrogen peroxide, however, IscA completely loses its iron binding activity, whereas CyaY becomes a competent iron-binding protein and attenuates the iron-mediated production of hydroxyl free radicals. Hydrogen peroxide appears to oxidize the iron binding thiol groups in IscA, thus blocking the iron binding in the protein. Once the oxidized thiol groups in IscA are re-reduced with the thioredoxin reductase system, the iron binding activity of IscA is fully restored. On the other hand, hydrogen peroxide has no effect on the iron binding carboxyl groups in CyaY, allowing the protein to bind iron under oxidative stress conditions. The results suggest that IscA is capable of recruiting intracellular iron for the iron-sulfur cluster assembly under normal physiological conditions, whereas CyaY may serve as an iron chaperon to sequester redox active free iron and alleviate cellular oxidative damage under oxidative stress conditions.
Evaluation of the evolutionary process within Populus caspica species from Hyrcanian forests by karyotype analysis

Caspian poplar (Populus caspica Bornm.) is distributed exclusively in the Hyrcanian forests. Hyrcanian forests are the final remnants of Tertiary temperate deciduous forests in Western Eurasia and worldwide. This species plays a significant ecological role in the protection of the natural environment in Hyrcanian forests. In this research, chromosome number and karyotype details of 11 populations of the species were investigated for the first time, using fresh root cuttings collected from mature trees in different parts of the forest, located in the northern parts of Iran. Pre-treatment, fixation, hydrolyzing, and staining were conducted by α-bromonaphthalene, carnoy’s solution, 1N HCl, and hematoxylin agent, respectively. Chromosomal data were analyzed according to a nested model based on a completely randomized design. Chromosome numbers of all of the populations were the same as 2n = 38, which mostly were medium region and sub-metacentric types. Significant differences were observed between the provinces and populations, based on chromosome length grand means, arm ratios and centromere indices. The results demonstrated that structural rearrangement has occurred within the studied populations and indicated an active evolutionary process within and between populations of the species due to natural hybridization. Also, these results showed that artificial inter-specific hybridization between the P. caspica and its relative species can be employed to broaden the ecological zone of the species.