Miracle-dz/UniFAR-FTUs huggingface dataset:
Immunoluminometric assay for the midregion of pro-atrial natriuretic peptide in human plasma.

The prohormone of atrial natriuretic peptide (proANP) is a polypeptide of 126 amino acids. Mature atrial natriuretic peptide (ANP) consists of amino acids 99–126 and comprises 98% of the natriuretic peptides in the circulation (1). The N-terminal portion of proANP, termed proANP1–98 or NT-proANP, has a much longer half-life than mature ANP and has therefore been suggested to be a more reliable analyte for measurement than mature ANP (2). In addition to other established indications, proANP has recently gained much interest as a potential new marker in the field of sepsis (3), emphasizing the need for a reliable assay for this molecule. All sandwich immunoassays developed for proANP to date use an antibody against the N-terminal region of proANP1–98 combined with a second antibody against either the midregion (4) or C-terminal region (5)(6). However, under certain conditions, the N-terminal region might be minimally accessible for antibody binding (7)(8). Despite the described long half-life of proANP, results from various competitive immunoassays as well as HPLC analyses indicate that proANP1–98 can be subject to further fragmentation (9)(10). We developed a new sandwich immunoassay for midregional proANP (amino acids 53–90; Fig. 1A⇓ ). With this assay, which was named B.R. A.H. M.S SERISTRA® (B.R.A.H.M.S AG), we measured proANP values in 325 healthy controls. EDTA-plasma samples were collected at a blood bank (Red Cross) from 325 consecutive healthy blood donors (age range, 18–67 years; 52.9% male) without clinical evidence of acute disease or a history of chronic illness. Blood donors with risk factors for heart failure were not enrolled in the study. Written consent was obtained from …
Hybrid Personalization For Recommendations

Herder, E. , & Karger, P. (2008). Hybrid Personalization for Recommendations. In J. Baumeister & M. Atzmuller, Proceedings of the 16th Workshop on Adaptivity and User Modeling in Interactive System, ABIS 2008 (pp. 20-25). October, 6-10, 2008, Wurzburg, Germany: Universitat Wurzburg. Website with link to proceedings: http://lwa08.informatik. uni-wuerzburg.de/Wiki.jsp? page=FGABIS08
Learning Ensembles of Convolutional Neural Networks

Ensemble learning is a method for generating multiple versions of a predictor network and using them to get an aggregated prediction. Given a learning set Ω consists of data {(yn, ~xn), n = 1, . , N} where y is the class label and ~x is the inputing feature, we train a predictor φ(~x,Ω). With different initialization, we obtain a series of predictors {φk}. Our object is to use the {φk} to get a better predictor, φA.
Characterizing weekly self-reported antihypertensive medication nonadherence across repeated occasions

Background Little is known about weekly variability in medication nonadherence both between and within persons. Purpose To characterize medication nonadherence across repeated, closely spaced occasions. Methods This prospective cohort study comprised four unannounced telephone assessment occasions, each separated by approximately 2 weeks. On each occasion, adult outpatients taking at least a single antihypertensive medication completed a measure of extent of, and reasons for, nonadherence. Results Two hundred and sixty-one participants completed 871 (83%) of 1,044 occasions. Nonadherence was reported on 152 (17.5%) of 871 occasions by 93 (36%) of 261 participants. The most commonly endorsed reasons for nonadherence were forgetting (39.5%), being busy (23.7%), and traveling (19.7%). Among 219 participants completing at least three occasions, 50% of the variability in extent of nonadherence was a result of within-person fluctuations, and 50% was a result of between-person differences. Conclusion Interventions to reduce nonadherence should be informed by variability in the extent of nonadherence and specific reasons for nonadherence.
Aperiodic Sequences With Uniformly Decaying Correlations With Applications to Compressed Sensing and System Identification

In this paper, we present a new family of discrete aperiodic sequences having “random like” uniformly decaying autocorrelation properties. The new class of infinite length aperiodic sequences are higher order chirps based on algebraic irrational numbers. We show the uniformly decaying autocorrelation property by exploiting results from the theory of continued fractions and diophantine approximations. Specifically, we demonstrate that every finite n-length truncation of a higher order chirp has a worst case autocorrelation that decays as $O(n^{-1/4})$. Construction of aperiodic sequences with good autocorrelation properties is motivated by the problem of system identification of finite dimensional linear systems with unmodeled dynamics. We also utilize the uniformly decaying autocorrelation property to bound the singular values for finite Toeplitz structured matrices formed from n-length higher order chirp sequences. These singular value bounds imply restricted isometry property (RIP) and lead to deterministic Toeplitz matrix constructions with RIP property.
Global well-posedness and multi-tone solutions of a class of nonlinear nonlocal cochlear models in hearing

We study a class of nonlinear nonlocal cochlear models of the transmission line type, describing the motion of basilar membrane (BM) in the cochlea. They are damped dispersive partial differential equations (PDEs) driven by time dependent boundary forcing due to the input sounds. The global well-posedness in time follows from energy estimates. Uniform bounds of solutions hold in the case of bounded nonlinear damping. When the input sounds are multi-frequency tones, and the nonlinearity in the PDEs is cubic, we construct smooth quasi-periodic solutions (multi-tone solutions) in the weakly nonlinear regime, where new frequencies are generated due to nonlinear interaction. When the input consists of two tones at frequencies f1, f2 (f1 < f2), and high enough intensities, numerical results illustrate the formation of combination tones at 2f1 − f2 and 2f2 − f1, in agreement with hearing experiments. We visualize the frequency content of solutions through the FFT power spectral density of displacement at selected spatial locations on the BM.
L-carnitine Supplemented Extender Improves Cryopreserved-thawed Cat Epididymal Sperm Motility

Cryopreservation of epididymal sperm is an effective technique to preserve genetic materials of domestic cats and wild felids when they unexpectedly die. However, this technique inevitably causes detrimental changes of cryopreserved-thawed spermatozoa, for example, by physical damage and excessive oxidative stress. L-carnitine is an antioxidant that has been used to improve sperm motility in humans and domestic animals. This study aimed to investigate the effects of L-carnitine on cat epididymal sperm quality following cryopreservation and thawing. After routine castration, cauda epididymides were collected from 60 cat testes. The epididymal spermatozoa from 3 cauda epididymides were pooled as 1 replicate. Spermatozoa samples (16 replicates) were examined for spermatozoa quality and then randomly divided into 4 groups: 0 mM L-carnitine (control), 12.5 mM, 25 mM and 50 mM L-carnitine. The sperm aliquots were then equilibrated and conventionally frozen. After thawing, sperm motility, plasma membrane integrity, DNA integrity and acrosome integrity were evaluated. The 25 mM L-carnitine significantly improved sperm motility compared with a control group (p<0.05), although this was not significantly different among other concentrations. In conclusion, supplementation of 25 mM L-carnitine in freezing extender improves cauda epididymal spermatozoa motility. The effects of L-carnitine on the levels of oxidative stress during freezing and thawing remains to be examined.
Towards Scaling Fully Personalized PageRank: Algorithms, Lower Bounds, and Experiments

Personalized PageRank expresses link-based page quality around userselected pages in a similar way as PageRank expresses quality over the entire web. Existing personalized PageRank algorithms can, however, serve online queries only for a restricted choice of pages. In this paper we achieve full personalization by a novel algorithm that precomputes a compact database; using this database, it can serve online responses to arbitrary user-selected personalization. The algorithm uses simulated random walks; we prove that for a fixed error probability the size of our database is linear in the number of web pages. We justify our estimation approach by asymptotic worst-case lower bounds: we show that on some sets of graphs, exact personalized PageRank values can only be obtained from a database of size quadratic in the number of vertices. Furthermore, we evaluate the precision of approximation experimentally on the Stanford WebBase graph.
Modelling Relative Price Variability and Aggregate Inflation in the United Kingdom

The relationship between relative price variability and aggregate inflation in the United Kingdom is used to illustrate a number of issues in econometric modeling methodology. The rigorous evaluation of models, especially testing for congruence and encompassing, is emphasized. The valuable role of recursive estimation methods in assessing model adequacy is demonstrated. Attention is drawn to the potential limitations of single-equation and univariate analysis of time-series data, and a recently proposed modeling strategy for analyzing nonstationary variables with cointegrating relationship, based on sequential reductions of a congruent VAR, is applied to a small system involving inflation and relative price variability. Copyright 1991 by The editors of the Scandinavian Journal of Economics.
The Influence of Season on the Gonad Index and Biochemical Composition of the Sea Urchin Paracentrotus lividus from the Golf of Tunis

Seasonal variation in the gonad weight and biochemical composition of the sea urchin Paracentrotus lividus from the Golf of Tunis (Tunisia) were studied between September 2003 and August 2004. The highest gonad indices occurred in March (16.71%). The spawning period occurred between April and July and resulted in a fall in gonad indices to low level (7.12 ± 0.12%). Protein constituted the main component of the gonad, and lipid and carbohydrate were found at appreciable amounts. Consistent with the gonad cycle, sea urchin biochemical components showed clear seasonal variation with a significant decrease during the spawning period. The polyunsaturated fatty acid (PUFA) group was found at high level (40% of the total fatty acids). Of the PUFA group, eicosapentaenoic (C20:5 n − 3) and eicosatetraenoic (C20:4 n − 3) were the most abundant gonadal lipids. The level of PUFA was significantly affected by temperature variation showing an increase during the cold months and a decrease in the hot months.
Why are children in the same family so different from one another?

Abstract One of the most important findings that has emerged from human behavioral genetics involves the environment rather than heredity, providing the best available evidence for the importance of environmental influences on personality, psychopathology, and cognition. The research also converges on the remarkable conclusion that these environmental influences make two children in the same family as different from one another as are pairs of children selected randomly from the population. The theme of the target article is that environmental differences between children in the same family (called “nonshared environment”) represent the major source of environmental variance for personality, psychopathology, and cognitive abilities. One example of the evidence that supports this conclusion involves correlations for pairs of adopted children reared in the same family from early in life. Because these children share family environment but not heredity, their correlation directly estimates the importance of shared family environment. For most psychological characteristics, correlations for adoptive “siblings” hover near zero, which implies that the relevant environmental influences are not shared by children in the same family. Although it has been thought that cognitive abilities represent an exception to this rule, recent data suggest that environmental variance that affects IQ is also of the nonshared variety after adolescence. The article has three goals: (1) To describe quantitative genetic methods and research that lead to the conclusion that nonshared environment is responsible for most environmental variation relevant to psychological development, (2) to discuss specific nonshared environmental influences that have been studied to date, and (3) to consider relationships between nonshared environmental influences and behavioral differences between children in the same family. The reason for presenting this article in BBS is to draw attention to the far-reaching implications of finding that psychologically relevant environmental influences make children in a family different from, not similar to, one another.
When helping hurts: miscarried helping in families of youth with chronic pain.

OBJECTIVE To examine "miscarried helping" as a maladaptive dyadic process in families of youth with chronic pain using the Actor-Partner Interdependence Model. METHODS 210 adolescents with chronic pain (mean = 14.23 years; 73.9% female) and their parents participating in a multicenter study completed measures assessing pain characteristics, miscarried helping, family functioning, parental protectiveness, and child depressive symptoms. RESULTS Multilevel modeling revealed significant actor effects of miscarried helping on family functioning for both parents and teens, but not partner effects. Individual-level factors, including child pain characteristics, depressive symptoms, and parental protectiveness, uniquely contributed to miscarried helping. CONCLUSIONS Higher perceptions of miscarried helping contribute to worse family functioning and may be a useful target for psychological intervention in parents of children with chronic pain. Parents who exhibit more protective responses to pain and youth with more depressive symptoms may be at increased risk for a miscarried helping process to develop.
On the Provable Convergence of Alternating Minimization for Matrix Completion

Alternating Minimization is a widely used and empirically successful framework for Matrix Completion and related low-rank optimization problems. We give a new algorithm based on Alternating Minimization that provably recovers an unknown low-rank matrix from a random subsample of its entries under a standard incoherence assumption while achieving a linear convergence rate. Compared to previous work our results reduce the provable sample complexity requirements of the Alternating Minimization approach by at least a quartic factor in the rank and the condition number of the unknown matrix. These improvements apply when the matrix is exactly low-rank and when it is only close to low-rank in the Frobenius norm. Underlying our work is a new robust convergence analysis of the well-known Subspace Iteration algorithm for computing the dominant singular vectors of a matrix also known as the Power Method. This viewpoint leads to a conceptually simple understanding of Alternating Minimization that we exploit. Additionally, we contribute a new technique for controlling the coherence of intermediate solutions arising in iterative algorithms. These techniques may be of interest beyond their application here.
The serine threonine kinase RIP3: lost and found

Receptor-interacting protein kinase-3 (RIP3, or RIPK3) is an essential protein in the “programmed”, or “regulated” necrosis cell death pathway that is activated in response to death receptor ligands and other types of cellular stress. Programmed necrotic cell death is distinguished from its apoptotic counterpart in that it is not characterized by the activation of caspases; unlike apoptosis, programmed necrosis results in plasma membrane rupture, thus spilling the contents of the cell and triggering the activation of the immune system and inflammation. Here we discuss findings, including our own recent data, which show that RIP3 protein expression is absent in many cancer cell lines. The recent data suggests that the lack of RIP3 expression in a majority of these deficient cell lines is due to methylation-dependent silencing, which limits the responses of these cells to pro-necrotic stimuli. Importantly, RIP3 expression may be restored in many cancer cells through the use of hypomethylating agents, such as decitabine. The potential implications of loss of RIP3 expression in cancer are explored, along with possible consequences for chemotherapeutic response. [BMB Reports 2015; 48(6): 303-312]
Detecting and exploiting data type symmetries of algebraic system nets during reachability analys

The symmetry redu tion method is a te hnique designed to alleviate the ombinatorial state spa e explosion problem by exploiting the symmetries of state spa es. This work des ribes a way how state spa e symmetries of a high-level Petri net formalism, algebrai system nets, an be dete ted and exploited during the rea hability analysis. The main idea is that permuting the domains of data types used in nets produ es orresponding permutations to the state spa e level. As the main result a suf ient ondition is de ned for data type domain permutations ensuring that the produ ed state spa e permutations are a tually automorphisms i.e. symmetries. Sin e veri ation of the ondition is shown to be a o-NPomplete problem, an approximation rule for the ondition is also given. Use of the developed theory is illustrated by de ning the lass of extended well-formed nets and by examining data type symmetries of su h nets. It is shown that he king the symmetri ity of two markings of a net in this lass is equivalent to he king whether two graphs are isomorphi .
Mining Analogical Libraries in Q&A Discussions -- Incorporating Relational and Categorical Knowledge into Word Embedding

Third-party libraries are an integral part of many software projects. It often happens that developers need to find analogical libraries that can provide comparable features to the libraries they are already familiar with. Existing methods to find analogical libraries are limited by the community-curated list of libraries, blogs, or Q&A posts, which often contain overwhelming or out-of-date information. In this paper, we present a new approach to recommend analogical libraries based on a knowledge base of analogical libraries mined from tags of millions of Stack Overflow questions. The novelty of our approach is to solve analogical-libraries questions by combining state-of-the-art word embedding technique and domain-specific relational and categorical knowledge mined from Stack Overflow. We implement our approach in a proof-of-concept web application (https://graphofknowledge.appspot.com/similartech). The evaluation results show that our approach can make accurate recommendation of analogical libraries (Precision@1=0.81 and Precision@5=0.67). Google Analytics of the website traffic provides initial evidence of the potential usefulness of our web application for software developers.
Non-state actors in international relations : the case of Germany

Introduction: Non-state actors and 'their' state - Anne-Marie Le Gloannec 1. The role of non-state actors in Germany's foreign policy of reconciliation: Catalysts, complements, conduits, or competitors? - Lily Gardner Feldman 2. The political dimension of Germany's unintentional power: The Konrad Adenauer Stiftung and Mexican democratization - Soledad Loaeza 3. Transnational relations and foreign policies. The interactions between non-state and state actors in the German assistance to central Europe (the political foundations in Poland and the program transform in Estonia) - Dorota Dakowska and Elsa Tulmets 4. State and non-state actors in the management of EU external borders - Gilles Lepesant 5. Reconstructing or reinforcing the 'state': The German Lander as transnational actors in Europe - Tanja Borzel 6. Transnational networking as institutional export: The case of Bavaria - Charlie Jeffery 7. German nuclear industry and Eastern Europe: The consequences of a paradigm change for state/non-state actors' relationship - Sabine Saurugger 8. Non-state actors and transnational relations: The German example - Fabienne Boudier-Bensebaa 9. Exporting or abandoning the 'German model'? Labour politics of German manufacturing firms in central Europe - Katharina Bluhm Conclusion - Anne-Marie Le Gloannec
Local and systemic cytokine levels in relation to changes in vaginal flora.

BACKGROUND Bacterial vaginosis (BV) is associated with increased risk of obstetrical and gynecologic complications and acquisition of sexually transmitted diseases. Despite this, very little is known about the pathogenesis of this disease. METHODS Interleukin (IL)-1 beta , tumor necrosis factor- alpha , IL-6, and IL-8 concentrations in vaginal wash and serum samples from women with normal flora, intermediate flora, and BV (determined by Nugent criteria) were measured by enzyme-linked immunosorbent assay. RESULTS Cytokine levels were not different between women with intermediate flora and women with BV. Women with either intermediate flora or BV had significantly higher concentrations of IL-1 beta in vaginal wash samples than did women with normal flora. The presence of IL-1 beta in vaginal wash samples was associated with >30 Gardnerella or Prevotella morphotypes per high-power field, as detected by Gram staining of vaginal swab specimens. Variation in the numbers of Lactobacillus and Mobiluncus species did not influence local cytokine levels. Serum cytokine levels were not influenced by any changes in vaginal flora. CONCLUSIONS Women with intermediate flora generate significant cytokine responses. It is possible that the risks associated with BV may also affect women with intermediate flora and that appropriate treatment may reduce such risk.
Media Coverage of Animal Handling and Welfare: Influence on Meat Demand

This article provides the first known examination of how animal welfare information provided by media sources impacts U.S. meat demand. Particular attention is focused on alternative techniques in deriving animal welfare media indices. Results suggest media attention to animal welfare has a small, but statistically significant impact on meat demand. Alternative derivations of media indices alter conclusions regarding spillover effects across meats, net impacts on total meat demand, and longevity of impacts. Articles referencing consumer groups impact demand more than those noting U.S. government or livestock industry entities.
The mythology of crime and criminal justice

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