Miracle-dz/UniFAR-FTUs huggingface dataset:
Cognitive-behavioral interventions in educational settings : a handbook for practice

Beck, Foreword. Part I: Foundations. Mennuti, Christner, An Introduction to Cognitive-Behavioral Therapy with Youth. Christner, Kamon, Mennuti, Implementation of Cognitive-Behavioral Therapy (CBT) to School-Based Mental Health: A Developmental Perspective. Ortiz, Multicultural Issues in School Mental Health: Responsive Intervention in the Educational Setting. Murphy, Christner, A Cognitive-Behavioral Case Conceptualization for Children and Adolescents. Part II: Application of CBT Interventions with Specific Disorders. Gosch, Flannery-Schroeder, Brecher, Anxiety Disorders: School-Based Cognitive-Behavioral Interventions. Kearney, Spear, School Refusal Behavior: School-Based Cognitive-Behavioral Interventions. Mulligan, Christner, Depression: School-Based Cognitive-Behavioral Interventions. West, Weinstein, Bipolar Disorder: School-Based Cognitive-Behavioral Interventions. Mennuti, Bloomgarden, Mathison, Gabriel, Adolescents with Eating Disorders: School-Based Cognitive-Behavioral Interventions. Lochman, Boxmeyer, Powell, Siddiqui, Stromeyer, Kelly, Anger and Aggression: School-Based Cognitive-Behavioral Interventions. Doll, Swearer, Collins, Chadwell, Dooley, Chapla, Bullying and Coercion: School-Based Cognitive-Behavioral Interventions. Perkins, Fischetti, Children with Learning Disabilities: School-Based Cognitive-Behavioral Interventions. DuPaul, Carson, Gormley, Junod, Flammer-Rivera, Attention Deficit Hyperactivity Disorder: School-Based Cognitive-Behavioral Interventions. Petronko, Kormann, Individuals with Developmental Disabilities: School-Based Cognitive-Behavioral Interventions. Bolton, McPoyle-Callahan, Christner, Autism: School-Based Cognitive-Behavioral Interventions. Weiler-Timmins, Lesbian, Gay, Bisexual, Transgendered, and Questioning (LGBTQ) Youth: School Climate, Stressors, and Interventions. Power, DeRosa, Children with Chronic Health Conditions: School-Based Cognitive-Behavioral Interventions. Forman, Sharp, Substance-Abuse Prevention: School-Based Cognitive-Behavioral Interventions. Part III: Application of CBT Interventions with Systems. Williams, Smallwood, Monahon, Cognitive-Behavioral Strategies for School Behavioral Consultation. Smallwood, Williams, Monahon, Cognitive-Behavioral Approaches to School-Crisis Response. Nelson, Schnorr, Powell, Huebner, Building Resilience in Schools. Livanis, Mulligan, Florin, Mougrabi, Incorporating Cognitive-Behavioral Therapy in a School-wide Positive Behavioral Support System: Promoting Good Mental Health in All Children. Part IV: Summary. Poponi, Mennuti, The Future of Cognitive-Behavioral Interventions in Schools.
Perception and automated assessment of audio quality in user generated content: An improved model

Technology to record sound, available in personal devices such as smartphones or video recording devices, is now ubiquitous. However, the production quality of the sound on this user-generated content is often very poor: distorted, noisy, with garbled speech or indistinct music. Our interest lies in the causes of the poor recording, especially what happens between the sound source and the electronic signal emerging from the microphone, and finding an automated method to warn the user of such problems. Typical problems, such as distortion, wind noise, microphone handling noise and frequency response, were tested. A perceptual model has been developed from subjective tests on the perceived quality of such errors and data measured from a training dataset composed of various audio files. It is shown that perceived quality is associated with distortion and frequency response, with wind and handling noise being just slightly less important. In addition, the contextual content of the audio sample was found to modulate perceived quality at similar levels to degradations such as wind and rendering those introduced by handling noise negligible.
Evolutionary Descent of Prion Genes from the ZIP Family of Metal Ion Transporters

In the more than twenty years since its discovery, both the phylogenetic origin and cellular function of the prion protein (PrP) have remained enigmatic. Insights into a possible function of PrP may be obtained through the characterization of its molecular neighborhood in cells. Quantitative interactome data demonstrated the spatial proximity of two metal ion transporters of the ZIP family, ZIP6 and ZIP10, to mammalian prion proteins in vivo. A subsequent bioinformatic analysis revealed the unexpected presence of a PrP-like amino acid sequence within the N-terminal, extracellular domain of a distinct sub-branch of the ZIP protein family that includes ZIP5, ZIP6 and ZIP10. Additional structural threading and orthologous sequence alignment analyses argued that the prion gene family is phylogenetically derived from a ZIP-like ancestral molecule. The level of sequence homology and the presence of prion protein genes in most chordate species place the split from the ZIP-like ancestor gene at the base of the chordate lineage. This relationship explains structural and functional features found within mammalian prion proteins as elements of an ancient involvement in the transmembrane transport of divalent cations. The phylogenetic and spatial connection to ZIP proteins is expected to open new avenues of research to elucidate the biology of the prion protein in health and disease.
Is it possible to standardize the treatment of primary spontaneous pneumothorax? Part 1: etiology, symptoms, diagnostics, minimally invasive treatment

The authors of this report present the history of primary spontaneous pneumothorax (PSP) treatment, its etiology, clinical symptoms, and diagnostic methodology. Further, they discuss minimally invasive methods of treating PSP such as thoracentesis and chemical pleurodesis. They discuss the pros and cons of each method, emphasizing that, according to the international recommendations, they should be used as the first line of treatment for PSP.
Binding Action and Emotion in Social Understanding

In social life actions are tightly linked with emotions. The integration of affective- and action-related information has to be considered as a fundamental component of appropriate social understanding. The present functional magnetic resonance imaging study aimed at investigating whether an emotion (Happiness, Anger or Neutral) dynamically expressed by an observed agent modulates brain activity underlying the perception of his grasping action. As control stimuli, participants observed the same agent either only expressing an emotion or only performing a grasping action. Our results showed that the observation of an action embedded in an emotional context (agent’s facial expression), compared with the observation of the same action embedded in a neutral context, elicits higher neural response at the level of motor frontal cortices, temporal and occipital cortices, bilaterally. Particularly, the dynamic facial expression of anger modulates the re-enactment of a motor representation of the observed action. This is supported by the evidence that observing actions embedded in the context of anger, but not happiness, compared with a neutral context, elicits stronger activity in the bilateral pre-central gyrus and inferior frontal gyrus, besides the pre-supplementary motor area, a region playing a central role in motor control. Angry faces not only seem to modulate the simulation of actions, but may also trigger motor reaction. These findings suggest that emotions exert a modulatory role on action observation in different cortical areas involved in action processing.
Functional MRI demonstrates pain perception in hand osteoarthritis has features of central pain processing.

BACKGROUND Hand osteoarthritis (HOA) is typified by pain and reduced function. We hypothesised that people with HOA have enhanced sensitivity and activation of peripheral nociceptors in the hand, thereby potentiating chronic pain. In our study we aimed to assess if central sensitisation mediates pain perception in osteoarthritis of the hand. METHODS Participants with proximal and distal interphalangeal joint (PIP/DIP) HOA and non-OA controls were recruited. Clinical pain scores using the visual analogue scale (VAS) were recorded before and after performing a painful hand task. Central pain processing was evaluated with functional brain neuroimaging (fMRI) using a finger flexion-extension (FFE) task performed over 3 minutes. Data was analysed with FMRIB software (www.fmrib.ox.ac.uk/fsl). Group mean activation of functional MRI signal between hand osteoarthritis and control non-arthritic participants was compared. RESULTS Our group of hand OA participants reported high pain levels compared with non-arthritic controls as demonstrated by the mean VAS in hand OA participants of 59.31± 8.19 mm compared to 4.00 ± 1.89 mm in controls (p < 0.0001), despite all participants reporting analgesic use. Functional MRI analysis showed increased activation in the thalamus, cingulate, frontal and somatosensory cortex in the hand OA group but not in controls (thresholded at p < 0.05). Regions of activation were mapped to Brodmann areas 3, 4, 6, 9, 13, 22, 24 and 44. Activated regions found in our study are recognised higher brain pain processing centres implicated in central sensitisation. CONCLUSIONS People with hand osteoarthritis demonstrated features of central sensitisation that was evident after a finger flexion-extension task using functional MRI. Functional MRI is a useful biomarker in detecting pain in hand osteoarthritis and could be used in future hand osteoarthritis pain studies to evaluate pain modulation strategies.
Significance of Side Information in the Graph Matching Problem

Percolation based graph matching algorithms rely on the availability of seed vertex pairs as side information to efficiently match users across networks. Although such algorithms work well in practice, there are other types of side information available which are potentially useful to an attacker. In this paper, we consider the problem of matching two correlated graphs when an attacker has access to side information, either in the form of community labels or an imperfect initial matching. In the former case, we propose a naive graph matching algorithm by introducing the community degree vectors which harness the information from community labels in an efficient manner. Furthermore, we analyze a variant of the basic percolation algorithm proposed in literature for graphs with community structure. In the latter case, we propose a novel percolation algorithm with two thresholds which uses an imperfect matching as input to match correlated graphs. We evaluate the proposed algorithms on synthetic as well as real world datasets using various experiments. The experimental results demonstrate the importance of communities as side information especially when the number of seeds is small and the networks are weakly correlated.
Relapse and morbidity in patients undergoing sentinel lymph node biopsy alone or with axillary dissection for breast cancer.

HYPOTHESIS Axillary relapse in node-negative patients staged with sentinel lymph node (SLN) biopsy alone is no more frequent than in patients treated with standard axillary dissection. Morbidity is less for patients who had SLN biopsy. DESIGN, SETTING, AND PATIENTS Between October 14, 1997, and August 31, 2001, 1253 consecutive women with primary invasive breast cancer were prospectively entered into an SLN biopsy database. Completion axillary dissection was performed in 164 patients after SLN biopsy as part of a training protocol. INTERVENTIONS Patients were contacted by questionnaire or telephone to determine breast cancer relapse; presence of arm lymphedema, arm pain, axillary infection, or seroma formation; and tumor recurrence or death. MAIN OUTCOME MEASURES chi2 or Fisher exact tests and Wilcoxon rank sum tests were used to analyze categorical and continuous variables. Logistic regression was used to analyze morbidity. RESULTS Of 1253 women, 894 (71%) were node negative by SLN biopsy alone (n = 730 [82%]) or SLN biopsy and completion axillary dissection (n = 164 [18%]). Questionnaires were completed by 776 patients (87%). Mean +/- SD follow-up was 2.4 +/- 0.9 years. Patients with axillary dissections reported a significantly higher occurrence of arm lymphedema (34%), arm pain (38%), seroma formation (24%), and infection (9%) vs SLN biopsy-only patients (6%, 14%, 7%, and 3%, respectively). One axillary relapse (0.1%) occurred during follow-up of 685 women who underwent SLN biopsy only. CONCLUSIONS With intermediate-term follow-up, there was 1 axillary recurrence in 685 SLN node-negative women, supporting use of SLN biopsy as an accurate method for staging breast cancer. Biopsy of the SLN was associated with significantly less morbidity than completion axillary dissection.
Identifying candidate genes involved in osteoarthritis through bioinformatics analysis.

OBJECTIVES This study aims to identify candidate genes and critical pathways involved in osteoarthritis (OA). METHODS Gene expression data of synovial membrane from OA patients and normal controls (NCs) were downloaded from database. Totally, 15 OA and 14 NC chips were available. Differentially expressed genes (DEGs) were identified through limma package (log2 fold change >0.585, false discovery rate (FDR) < 0.05), and protein-protein interaction (PPI) network was constructed using STRING. Moreover, perturbation and pathway enrichment analyses were performed through PerturbationAnalyzer in Cytoscape (iterative criteria <1×e-10) and clusterProfiler package (FDR <0.05), respectively. RESULTS Totally, 236 up-regulated and 290 down-regulated DEGs were identified. In PPI network, 10 hub genes were found, including VEGFA, IL6, JUN, IL1B, ICAM1, ATF3, IL8, EGR1, CDKN1A, and JUNB. After perturbation analysis, 32 DEGs were passively and significantly changed, like PISD, RARRES3, EIF4G1, and EPHA3. Furthermore, 526 DEGs were enriched in 176 pathways, and pathway cross-talk network was constructed, involving 12 pathways and 66 cross-talks. CONCLUSIONS Pathways like rheumatoid arthritis, osteoclast differentiation, and cytokine-cytokine receptor interaction might play critical roles in OA, and previously unreported genes VEGFA, JUN, JUNB, PISD, RARRES3, EIF4G1, and EPHA3 might participate in OA, providing novel directions for drug targeting.
Scattering from nonspherical Chebyshev particles. I: cross sections, single-scattering albedo, asymmetry factor, and backscattered fraction.

In this paper, we study the behavior of the scattering efficiency Qsca, the absorption efficiency Qabs, the single-scattering albedo ω, the asymmetry factor g, and the backscattered fraction for isotropically incident radiation β for randomly oriented rotationally symmetric nonspherical particles of radii r = r0[1 + ∊Tn(cosθs)], where Tn is a Chebyshev polynomial of order n. By taking n = 2,3,4,6,8, and 20, and ∊ = −0. 2 to 0.2 in steps of 0.05, twenty-three different shapes have been considered for these Chebyshev particles. The scattering calculations have been carried out using the Extended Boundary Conditions Method for individual particles with refractive index m∼=1.5−0.02i in the equal-volume-sphere size parameter range 1 ≤ x ≤ 25. Unshape-averaged and shape-averaged nonspherical single-scattering quantities have then been compared to corresponding size-averaged (over Δx = 0.1x) spherical results. It is shown that nonsphericity always increases Qabs for size parameters larger than ∼10, while it decreases g—and correspondingly increases β—in the size range 8 ≤ x ≤ 15. Qsca seems to be on the average somewhat larger for nonspherical particles, while ω tends to be smaller. Concavity almost always enhances the spherical–nonspherical differences.
The Voluntary Adoption of Islamic Stigma Symbols

Dans cet article, l'A se penche sur l'adoption volontaire de signes distinctifs relatifs a l'appartenance a l'islam dans les espaces publics. L'A revient sur la notion d'intimite et d'identite collective musulmane pour expliquer et justifier le port du voile et de la barbe. La modernite occidentale souhaite l'egalite des sexes et la liberte de partager l'espace public entre hommes et femmes, ce qui reste pour l'instant incompatible avec la pratique traditionnelle de l'islam
Efficient algorithms for multichannel extensions of Itakura-Saito nonnegative matrix factorization

This paper proposes new algorithms for multichannel extensions of nonnegative matrix factorization (NMF) with the Itakura-Saito (IS) divergence. We employ Hermitian positive definite matrices for modeling the covariance matrix of a multivariate complex Gaussian distribution. Such matrices are basically estimated for NMF bases, but a source separation task can be performed by introducing variables that relate NMF bases and sources. The new algorithms are derived by using a majorization scheme with properly designed auxiliary functions. The algorithms are in the form of multiplicative updates, and exhibit good convergence behavior. We have succeeded in separating a professionally produced music recording into its vocal and guitar components.
Molecular prevalence and antibiotics resistance pattern of class A bla CTX-M-1 and bla TEM-1 beta lactamases in uropathogenic Escherichia coli isolates from Pakistan.

BACKGROUND/AIM Extended spectrum beta lactamase (ESBL) production among E. coli is one of the principal mechanisms that augment resistance to antibiotics. In the current study the molecular detection of class A beta lactamases among uropathogenic Escherichia coli was evaluated. MATERIALS AND METHODS A total of 355 urine samples were collected from a tertiary care hospital in Peshawar. The ESBL production among E. coli isolates was detected by using the disc synergy diffusion method. Moreover, the molecular detection of bla TEM-1 and bla CTX-M-1 ESBLs, the antibiotic resistance pattern, and the minimum inhibitory concentrations (MICs) were also documented. RESULTS Among the 355 urine samples, 157 isolates were E. coli, and 23.56% of the isolates were ESBL E. coli. Among phenotypic ESBL producers, bla CTX-M-1 and bla TEM-1 were found in 59.45% and 40.54% of the isolates, respectively. A high resistance rate was observed against aztreonam (97.29%), while the lowest resistance was observed against imipenem (2.7%). The MICs of ESBLs E. coli for ceftriaxone, ciprofloxacin, and gentamicin was >512 µg/mL, 4 µg/mL to 128 µg/mL, and 1 µg/mL to 14 µg/mL respectively. CONCLUSION The present study showed that bla CTX-M-1 ESBL production is more prevalent in our clinical E. coli isolates. More often the ESBLs were resistant to commonly used antibiotics.
Open Access Study Protocol a Prospective Randomised, Open-labeled, Trial Comparing Sirolimus-containing versus Mtor-inhibitor-free Immunosuppression in Patients Undergoing Liver Transplantation for Hepatocellular Carcinoma

article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: The potential anti-cancer effects of mammalian target of rapamycin (mTOR) inhibitors are being intensively studied. To date, however, few randomised clinical trials (RCT) have been performed to demonstrate anti-neoplastic effects in the pure oncology setting, and at present, no oncology endpoint-directed RCT has been reported in the high-malignancy risk population of immunosuppressed transplant recipients. Interestingly, since mTOR inhibitors have both immunosuppressive and anti-cancer effects, they have the potential to simultaneously protect against immunologic graft loss and tumour development. Therefore, we designed a prospective RCT to determine if the mTOR inhibitor sirolimus can improve hepatocellular carcinoma (HCC)-free patient survival in liver transplant (LT) recipients with a pre-transplant diagnosis of HCC. Methods/Design: The study is an open-labelled, randomised, RCT comparing sirolimus-containing versus mTOR-inhibitor-free immunosuppression in patients undergoing LT for HCC. Patients with a histologically confirmed HCC diagnosis are randomised into 2 groups within 4-6 weeks after LT; one arm is maintained on a centre-specific mTOR-inhibitor-free immunosuppressive protocol and the second arm is maintained on a centre-specific mTOR-inhibitor-free immunosuppressive protocol for the first 4-6 weeks, at which time sirolimus is initiated. A 2 1/2-year recruitment phase is planned with a 5-year follow-up, testing HCC-free survival as the primary endpoint. Our hypothesis is that sirolimus use in the second arm of the study will improve HCC-free survival. The study is a non-commercial investigator-initiated trial (IIT) sponsored by the University Hospital Regensburg and is endorsed by the European Liver and Intestine Transplant Association; 13 countries within Europe, Canada and Australia are participating. Discussion: If our hypothesis is correct that mTOR inhibition can reduce HCC tumour growth while simultaneously providing immunosuppression to protect the liver allograft from rejection, patients should experience less post-transplant problems with HCC recurrence, and therefore could expect a longer and better quality of life. A positive outcome will likely change the standard of posttransplant immunosuppressive care for LT patients with HCC. Background Patients with HCC that receive a LT in an attempt to cure their cancer and any superimposed liver disease face at least two major issues. First, the patient requires adequate immunosuppressive medication to avoid rejection of the liver allograft. Second, the patient has a risk that the HCC recurrence could recur, especially when in an immunosuppressed state. Even when …
Circulatory Response to the Upright Posture

GENERAL RESPONSE TO ORTHOSTATIC STRESS. The Upright Posture in the Human-General. Pressure-Volume-Flow Relations in the Standing Position. Methods for Study of Hemodynamic Changes During Orthostasis. Blood Volume Displacement During Head-Up Posture. Compensatory Responses to the Head-Up Posture. Mechanism of Circulatory Response to Orthostasis. Effects of Lower Body Negative Pressure (LBNP). Prolonged Orthostatic Stress and Fainting. Variability in Orthostatic Stress Responses. PHYSICAL FITNESS AND ORTHOSTATIC TOLERANCE. Research Findings Which Suggest That Orthostatic Tolerance May Not Be Influenced by Aerobic Fitness. Research Findings Which Suggest That Orthostatic Tolerance May Be Influenced by Aerobic Fitness. Effects of Aerobic Fitness on Physical, Neural, and Hormonal Factors Involved in Blood Pressure Homeostasis During Orthostatic Stress. WEIGHTLESSNESS AND RESPONSE TO ORTHOSTATIC STRESS. Overview of U.S. and Soviet Human Space Flights Through May 1989. Physiological Responses to Space Flight and Simulated Weightlessness. AGE AND THE RESPONSE TO ORTHOSTATIC STRESS. General Circulatory Changes with Age. Orthostatic Cardiovascular Response. Mechanism of Aging Response to Orthostasis. Factors Affecting Postural Tolerance in the Elderly. SEX DIFFERENCES IN RESPONSE TO ORTHOSTATIC AND OTHER STRESSES. Cardiovascular Physiology of Women. Cardiovascular Disease in Women. Women's Responses to Exercise and Nonorthostatic Stresses. Women's Responses to "Orthostatic" Stresses. ORTHOSTATIC HYPOTENSION. Definition and Classification of Orthostatic Hypotension. Causes. Evaluation. Therapy. 200 pp., 7x10, 1990, ISBN 0-8493-6518-X.