Miracle-dz/UniFAR-FTUs huggingface dataset:
Compensatory cortical activation during performance of an attention task by patients with diffuse axonal injury: a functional magnetic resonance imaging study

Objective: To determine how cortical compensation occurs in higher cognitive systems during the recovery phase of diffuse axonal injury (DAI). Design: 12 right-handed patients with a magnetic resonance imaging (MRI) lesion pattern compatible with pure DAI were identified. Pure DAI was defined as finding of traumatic microbleeds on T2*-weighted gradient-echo images in the absence of otherwise traumatic or non-traumatic MRI abnormalities. 12 matched healthy controls were also enrolled. Functional magnetic resonance imaging (fMRI) was used to assess brain activation during a working memory test (Paced Visual Serial Attention Test (PVSAT)). Results: No significant group differences were observed in reaction times for the PVSAT. Although patients with pure DAI committed a few errors during the PVSAT, controls respond correctly to each probe. Controls showed activations in the left frontal gyrus, left parietal gyrus and right inferior parietal gyrus. Patients with pure DAI showed activations in the left inferior frontal gyrus, right inferior frontal gyrus and right middle frontal gyrus. Between-group analysis of the PVSAT task showed significantly greater activation of the right inferior frontal gyrus (BA 45) and right middle frontal gyrus (BA 9) in patient with pure DAI versus controls. Conclusions: Patients with pure DAI require compensatory activation of the contralateral (right) prefrontal region to carry out activities similar to healthy controls. These findings provide further evidence for the adaptive capacity of neuronal systems and brain plasticity during the recovery stages of DAI.
The Extent of Cognitive Impairment in Multiple Sclerosis

The prevalence of cognitive impairment in large heterogeneous groups of MS patients has been demonstrated by formal psychometric assessment to be 43–70%, with the higher prevalence rates from clinic samples. Cognitive impairment has been reported at all stages and in all subtypes of the disease. In the comparative study by Potagas et al., the cognitive impairment prevalence rates were 27.3% in clinically isolated syndrome (CIS), 40.0% in relapsing–remitting MS (RRMS), 56.5% in primary progressive MS (PPMS) and 82.8% in secondary progressive MS (SPMS). A cognitive impairment prevalence of 45% has been demonstrated in benign MS. Cognitive impairment tends to progress over time, but rarely in the space of a few years. The Impact of Cognitive Impairment in Multiple Sclerosis Cognitive impairment has been shown to have an adverse effect on the lives of people with MS, over and above that imposed by their physical impairments. Cognitive impairment leads to reduced employment, social function, physical independence, sexual function, progress in rehabilitation, everyday life activities, safety in driving and adherence to medication. Poorer self-reported scores on formal measures of quality of life have also been linked to cognitive status. Reduced information-processing speed has been associated with lower quality of life.
MiRNA-891a-5p mediates HIV-1 Tat and KSHV Orf-K1 synergistic induction of angiogenesis by activating NF-κB signaling

Co-infection with HIV-1 and Kaposi's sarcoma-associated herpesvirus (KSHV) is the cause of aggressive AIDS-related Kaposi's sarcoma (AIDS-KS) characterized by abnormal angiogenesis. The impact of HIV-1 and KSHV interaction on the pathogenesis and extensive angiogenesis of AIDS-KS remains unclear. Here, we explored the synergistic effect of HIV-1 Tat and KSHV oncogene Orf-K1 on angiogenesis. Our results showed that soluble Tat or ectopic expression of Tat enhanced K1-induced cell proliferation, microtubule formation and angiogenesis in chorioallantoic membrane and nude mice models. Mechanistic studies revealed that Tat promoted K1-induced angiogenesis by enhancing NF-κB signaling. Mechanistically, we showed that Tat synergized with K1 to induce the expression of miR-891a-5p, which directly targeted IκBα 3′ untranslated region, leading to NF-κB activation. Consequently, inhibition of miR-891a-5p increased IκBα level, prevented nuclear translocation of NF-κB p65 and ultimately suppressed the synergistic effect of Tat- and K1-induced angiogenesis. Our results illustrate that, by targeting IκBα to activate the NF-κB pathway, miR-891a-5p mediates Tat and K1 synergistic induction of angiogenesis. Therefore, the miR-891a-5p/NF-κB pathway is important in the pathogenesis of AIDS-KS, which could be an attractive therapeutic target for AIDS-KS.
Communication, Decision-Making and the Optimal Degree of Transparency of Monetary Policy Committees

This paper develops a theoretical model of dynamic decision-making of a monetary policy committee with heterogeneous members. It investigates the optimal transparency, and the optimal way of transmitting information of committees, by analysing the effects different communication strategies have on financial markets. It is shown that the communication strategy of the central bank committee has a significant effect on the predictability of monetary policy decisions when there is asymmetric information between the committee and market agents. Transparency about the diversity of views of the committee surrounding the economic outlook makes future monetary policy more predictable. However, communicating the diversity of views regarding monetary policy decisions may lead to less predictability of monetary policy in the short term. In addition, it is shown that communication in the form of voting records has the greatest effect on market participants' near term policy expectations. These results support findings of the empirical literature and have strong implications for the optimal communication strategies of committees including the question whether individual voting records should be published.
TWO-POINT FUNCTIONS AND QUANTUM FIELDS IN DE SITTER UNIVERSE

We present a theory of general two-point functions and of generalized free fields in d-dimensional de Sitter space-time which closely parallels the corresponding Minkowskian theory. The usual spectral condition is now replaced by a certain geodesic spectral condition, equivalent to a precise thermal characterization of the corresponding “vacuum” states. Our method is based on the geometry of the complex de Sitter space-time and on the introduction of a class of holomorphic functions on this manifold, called perikernels, which reproduce mutatis mutandis the structural properties of the two-point correlation functions of the Minkowskian quantum field theory. The theory contains as basic elementary case the linear massive field models in their “preferred” representation. The latter are described by the introduction of de Sitter plane waves in their tube domains which lead to a new integral representation of the two-point functions and to a Fourier-Laplace type transformation on the hyperboloid. The Hilbert space structure of these theories is then analysed by using this transformation. In particular we show the Reeh-Schlieder property. For general two-point functions, a substitute to the Wick rotation is defined both in complex space-time and in the complex mass variable, and substantial results concerning the derivation of Kallen-Lehmann type representation are obtained.
Bridging Faith: The Effect of Evangelical Social Service

This article uses qualitative data gathered from a case study of a service program at an evangelical Christian university to examine the links between volunteering and the development of social capital and civic engagement in college students. The students were asked to describe their service experiences and to discuss the ways in which these experiences affected their connections with others and the influence that these experiences had on their perspectives on social action. Data gathered from these interviews provided new insights into the ways that volunteering promotes social capital formation in students and changes their perspectives on civic engagement. The data also revealed ways that the religious tradition of students shaped their ideas about forming relationships and social action. The results show that bridging social capital formation is far and away the most salient aspect of the volunteer experience for these students. The guiding social engagement framework for these evangelical students is relationships, which, for them, took precedence over meeting practical needs and working for structural change. Keywords: social capital, civic engagement, social action, evangelicals, bridging capital, Christian college students
Genetic Susceptibility to Type 2 Diabetes and Obesity: Follow-Up of Findings from Genome-Wide Association Studies

Elucidating the underlying genetic variations influencing various complex diseases is one of the major challenges currently facing clinical genetic research. Although these variations are often difficult to uncover, approaches such as genome-wide association studies (GWASs) have been successful at finding statistically significant associations between specific genomic loci and disease susceptibility. GWAS has been especially successful in elucidating genetic variants that influence type 2 diabetes (T2D) and obesity/body mass index (BMI). Specifically, several GWASs have confirmed that a variant in transcription factor 7-like 2 (TCF7L2) confers risk for T2D, while a variant in fat mass and obesity-associated protein (FTO) confers risk for obesity/BMI; indeed both of these signals are considered the most statistically associated loci discovered for these respective traits to date. The discovery of these two key loci in this context has been invaluable for providing novel insight into mechanisms of heritability and disease pathogenesis. As follow-up studies of TCF7L2 and FTO have typically lead the way in how to follow up a GWAS discovery, we outline what has been learned from such investigations and how they have implications for the myriad of other loci that have been subsequently reported in this disease context.
STEM Education

STEM education in schools has become the subject of energetic promotion by universities and policymakers. The mythical narrative of STEM in crisis has driven policy to promote STEM education throughout the world in order to meet the challenges of future workforce demands alongside an obsession with high-stakes testing for national and international comparisons as a proxy for education quality. Unidisciplinary emphases in the curriculum have failed to deliver on the goal to attract more students to pursue STEM courses and careers or to develop sophisticated STEM literacies. A radical shift in the curriculum toward integrated STEM education through multidisciplinary/ interdisciplinary/ transdisciplinary projects is required to meet future challenges. Project-based activities that engage students in solving real-world problems requiring multiple perspectives and skills that are authentically assessed by autonomous professional teachers are needed. Governments and non-government sponsors should support curriculum development with teachers, and their continuing professional development in this process. Integrating STEM with creative expression from the arts shows promise at engaging students and developing their STEM literacies. Research into the efficacy of such projects is necessary to inform authorities and teachers of possibilities for future developments. Foci for further research also are identified.
Maturation-Dependent Vulnerability of Oligodendrocytes to Oxidative Stress-Induced Death Caused by Glutathione Depletion

Death of oligodendrocyte (OL) precursors can be triggered in vitro by cystine deprivation, a form of oxidative stress that involves depletion of intracellular glutathione. We report here that OLs demonstrate maturation-dependent differences in survival when subjected to free radical-mediated injury induced by glutathione depletion. Using immunopanning to isolate rat preoligodendrocytes (preOLs), we generated highly enriched populations of preOLs and mature OLs under chemically defined conditions. Cystine deprivation caused a similar decrease in glutathione levels in OLs at both stages. However, preOLs were completely killed by cystine deprivation, whereas mature OLs remained viable. Although the glutathione-depleting agents buthionine sulfoximine and diethylmaleate were more potent in depleting glutathione in mature OLs, both agents were significantly more toxic to preOLs. Glutathione depletion markedly increased intracellular free radical generation in preOLs, but not in mature OLs, as indicated by oxidation of the redox-sensitive probe dihydrorhodamine 123. The antioxidants α-tocopherol, idebenone, and glutathione monoethylester prevented the oxidation of dihydrorhodamine in cystine-depleted preOLs and markedly protected against cell death. When the intracellular glutathione level was not manipulated, preOLs were also more vulnerable than mature OLs to exogenous free radical toxicity generated by a xanthine–xanthine oxidase system. Ultrastructural features of free radical-mediated injury in glutathione-depleted preOLs included nuclear condensation, margination of chromatin, and mitochondrial swelling. These observations indicate that preOLs are significantly more sensitive to the toxic effects of glutathione depletion and that oligodendroglial maturation is associated with decreased susceptibility to oxidative stress.
The Use of Members of the Family Chydoridae (Anomopoda, Branchiopoda) as an Indicator of Lake Ecological Quality in Ireland

Abstract:We sampled chydorids (Branchiopoda, Anomopoda) from 29 Irish lakes between June 1996 and July 1997 in order to assess the usefulness of this group as an indicator of lake ecological quality, as required by the recently published EU Water Framework Directive. The lakes represented a wide range of the physicochemical conditions found in Irish lakes We identified 31 species of Chydoridae from the lakes and used multivariate analysis to elucidate the relationship between the chydorids and their environment Groups of lakes were found to have distinct chydorid communities, the structure and composition of which depended on environmental variables such as total phosphorus, total nitrogen, alkalinity, conductivity and lake size. The study highlights the potential value of this group as a biotic indicator of ecological change in Irish lakes.
The Contribution of α-Synuclein Spreading to Parkinson's Disease Synaptopathy

Synaptopathies are diseases with synapse defects as shared pathogenic features, encompassing neurodegenerative disorders such as Parkinson's disease (PD). In sporadic PD, the most common age-related neurodegenerative movement disorder, nigrostriatal dopaminergic deficits are responsible for the onset of motor symptoms that have been related to α-synuclein deposition at synaptic sites. Indeed, α-synuclein accumulation can impair synaptic dopamine release and induces the death of nigrostriatal neurons. While in physiological conditions the protein can interact with and modulate synaptic vesicle proteins and membranes, numerous experimental evidences have confirmed that its pathological aggregation can compromise correct neuronal functioning. In addition, recent findings indicate that α-synuclein pathology spreads into the brain and can affect the peripheral autonomic and somatic nervous system. Indeed, monomeric, oligomeric, and fibrillary α-synuclein can move from cell to cell and can trigger the aggregation of the endogenous protein in recipient neurons. This novel “prion-like” behavior could further contribute to synaptic failure in PD and other synucleinopathies. This review describes the major findings supporting the occurrence of α-synuclein pathology propagation in PD and discusses how this phenomenon could induce or contribute to synaptic injury and degeneration.
A preclinical evaluation of alternative site for islet allotransplantation

The bone marrow cavity (BMC) has recently been identified as an alternative site to the liver for islet transplantation. This study aimed to compare the BMC with the liver as an islet allotransplantation site in diabetic monkeys. Diabetes was induced in Rhesus monkeys using streptozocin, and the monkeys were then divided into the following three groups: Group1 (islets transplanted in the liver with immunosuppressant), Group 2 (islets transplanted in the tibial BMC), and Group 3 (islets transplanted in the tibial BMC with immunosuppressant). The C-peptide and blood glucose levels were preoperatively measured. An intravenous glucose tolerance test (IVGTT) was conducted to assess graft function, and complete blood cell counts were performed to assess cell population changes. Cytokine expression was measured using an enzyme-linked immune sorbent assay (ELISA) and MILLIPLEX. Five monkeys in Group 3 exhibited a significantly increased insulin-independent time compared with the other groups (Group 1: 78.2 ± 19.0 days; Group 2: 58.8 ± 17.0 days; Group 3: 189.6 ± 26.2 days) and demonstrated increases in plasma C-peptide 4 months after transplantation. The infusion procedure was not associated with adverse effects. Functional islets in the BMC were observed 225 days after transplantation using the dithizone (DTZ) and insulin/glucagon stains. Our results showed that allogeneic islets transplanted in the BMC of diabetic Rhesus monkeys remained alive and functional for a longer time than those transplanted in the liver. This study was the first successful demonstration of allogeneic islet engraftment in the BMC of non-human primates (NHPs).
Stable transmission for a cognitive-shared channel with rechargeable transmitters

In this paper, we study the maximum stable throughput region of the proposed systems using stochastic dominance technique for optimizing utilization of a cognitive shared channel. A cognitive protocol on the general multipacket reception channel model is adopted [1], [2], where the primary transmission may succeed even in the presence of secondary transmission. Thus the cognitive user can increase its throughput through not only utilizing the idle periods of the primary user also randomly accessing the channel by some probability. We also propose two system models different from the one presented in [2] that first, the secondary transmitter harvests energy for transmission, and second, both primary user (PU) and secondary user are equipped with rechargeable batteries. Then the maximum stable throughput region for the two proposed models are studied.
Adsorption of Selected Pharmaceutical Compounds onto Activated Carbon in Dilute Aqueous Solutions Exemplified by Acetaminophen, Diclofenac, and Sulfamethoxazole

The adsorption of three pharmaceuticals, namely, acetaminophen, diclofenac, and sulfamethoxazole onto granular activated carbon (GAC), was investigated. To study competitive adsorption, both dynamic and steady-state adsorption experiments were conducted by careful selection of pharmaceuticals with various affinities and molecular size. The effective diffusion coefficient of the adsorbate was increased with decease in particle size of GAC. The adsorption affinity represented as Langmuir was consistent with the ranking of the octanol-water partition coefficient, K ow. The adsorption behavior in binary or tertiary systems could be described by competition adsorption. In the binary system adsorption replacement occurred, under which the adsorbate with the smaller K ow was replaced by the one with larger K ow. Results also indicated that portion of the micropores could be occupied only by the small target compound, but not the larger adsorbates. In multiple-component systems the competition adsorption might significantly be affected by the macropores and less by the meso- or micropores.
What Can Be Verified Locally?

We are considering distributed network computing, in which computing entities are connected by a network modeled as a connected graph. These entities are located at the nodes of the graph, and they exchange information by message-passing along its edges. In this context, we are adopting the classical framework for local distributed decision, in which nodes must collectively decide whether their network configuration satisfies some given boolean predicate, by having each node interacting with the nodes in its vicinity only. A network configuration is accepted if and only if every node individually accepts. It is folklore that not every Turing-decidable network property (e.g., whether the network is planar) can be decided locally whenever the computing entities are Turing machines (TM). On the other hand, it is known that every Turing-decidable network property can be decided locally if nodes are running non-deterministic Turing machines (NTM). However, this holds only if the nodes have the ability to guess the identities of the nodes currently in the network. That is, for different sets of identities assigned to the nodes, the correct guesses of the nodes might be different. If one asks the nodes to use the same guess in the same network configuration even with different identity assignments, i.e., to perform identity-oblivious guesses, then it is known that not every Turing-decidable network property can be decided locally. In this paper, we show that every Turing-decidable network property can be decided locally if nodes are running alternating Turing machines (ATM), and this holds even if nodes are bounded to perform identity-oblivious guesses. More specifically, we show that, for every network property, there is a local algorithm for ATMs, with at most 2 alternations, that decides that property. To this aim, we define a hierarchy of classes of decision tasks where the lowest level contains tasks solvable with TMs, the first level those solvable with NTMs, and level k contains those tasks solvable with ATMs with k alternations. We characterize the entire hierarchy, and show that it collapses in the second level. In addition, we show separation results between the classes of network properties that are locally decidable with TMs, NTMs, and ATMs. Finally, we establish the existence of completeness results for each of these classes, using novel notions of local reduction.
Theorizing Regulatory Intermediaries

Regulation is typically conceived as a two-party relationship between a rule-maker or regulator (R) and a rule-taker or target (T). We set out an agenda for the study of regulation as a three- (or more) party relationship, with intermediaries (I) at the center of the analysis. Intermediaries play major and varied roles in regulation, from providing expertise and feedback to facilitating implementation, from monitoring the behavior of regulatory targets to building communities of assurance and trust. After developing the basic regulator-intermediary-target (RIT) model, we discuss important extensions and variations of the model. We then discuss the varieties of regulatory capture that may appear where intermediaries are involved.
Active delivery to the brain by chemotaxis

Department of Chemistry, University College London, London UK Department of Chemical Engineering, University College London, London UK Department of Chemistry, University of Basel, Basel, Switzerland Department of Pharmaceutical Science, Kings College London, London, United Kingdom †These authors have contributed equally ∗Corresponding author: Prof Giuseppe Battaglia, Christopher Ingold Building, University College London, 20 Gordon Street, WC1H 0AJ, London, United Kingdom, Email:g.battaglia@ucl.ac. uk Tel: +44(0)2076794688