Miracle-dz/UniFAR-FTUs huggingface dataset:
Predictive Variables for Abnormal Comprehensive Metabolic Panel Testing and Potential Cost Savings in Children Receiving Pediatric Emergency Department Care

Objective The aim of this study was to determine variables predictive of abnormal comprehensive metabolic panel (CMP) results in pediatric emergency department (PED) patients and the potential cost savings of a basic metabolic panel (BMP) versus a CMP. Methods This is a retrospective cross-sectional descriptive study of children (<18 y) at an urban academic PED (annual census, 22,000). Clinical data included 12 clinical variables: right upper quadrant pain, overdose, emesis, liver disorder, malignancy, heart disease, bleeding disorder, jaundice, right upper quadrant tenderness, hepatomegaly, ascites/peripheral edema and shock, and the liver function test (LFT) results not in a BMP (alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, total bilirubin, total protein, and albumin). Results There were 207 children in the study population. The mean age was 8 years. There were 106 boys (51%). Variables significantly associated with abnormal LFT result were history of liver disease (P = 0.007), history of heart disease (P = 0.040), jaundice (P = 0.045), and hepatomegaly (P = 0.048). The false-negative rate was 16%. However, of the 10 patients for whom this false-negative rate remained true, the LFT values were marginally abnormal, and performance of further investigation of these results was minimal to none. There were 66 patients with no clinical variables and normal CMP results. With a cost difference of $21 between BMP and CMP, this gives a potential savings of $7125 if extrapolated for 1 year in our PED. Conclusions Limiting testing to a BMP for patients with none of the 12 clinical variables has the potential annual cost savings of $7125.
Zero-Shot Question Generation from Knowledge Graphs for Unseen Predicates and Entity Types

We present a neural model for question generation from knowledge graphs triples in a “Zero-shot” setup, that is generating questions for predicate, subject types or object types that were not seen at training time. Our model leverages triples occurrences in the natural language corpus in a encoder-decoder architecture, paired with an original part-of-speech copy action mechanism to generate questions. Benchmark and human evaluation show that our model outperforms state-of-the-art on this task.
A STUDY OF MICRO-CHANNELING ON GLASSES USING AN ABRASIVE SLURRY JET

A study of micro-channeling on glasses using an abrasive slurry jet is presented. The mechanism of channel formation is discussed. It is found that the cross section of the channel is characterized by a V-shape, where the maximum channel width is larger than the nozzle inner diameter. The surface morphology features with two types of major and minor wave patterns. The major wave patterns with large wavelength developed along the channel are caused by the jet deflection during nozzle traverse motion. The minor wave patterns are a result of the secondary viscous flow that is induced by the impact of jet on the target. Material was eroded predominantly by the ductile mode, resulting in a smooth surface. The depth of the channel is mainly affected by the jet kinetic energy transferring to material via abrasive particles. In contrast, the viscous flow plays a main role in the formation of the channel width. The turbulent flow that drives the moving particles accumulated at the bottom of the channel contributes to the formation of channel wall inclination. With a proper control of the operating parameters, this technology can be used for machining micro-channel on brittle materials to achieve high surface quality.
Attention control: Relationships between self-report and behavioural measures, and symptoms of anxiety and depression

Individual differences in attention control are proposed to contribute to anxiety and depression. However, self-reported attention control, assessed on the Attentional Control Scale (ACS), appears to be a heterogeneous construct with separate components of focusing (e.g., concentrating, resisting distraction) and shifting (e.g., flexible switching of attention between tasks). Moreover, these constructs are proposed to relate differently to anxiety and depression. Two studies are reported which investigated relationships between ACS focusing and shifting and (i) an objective behavioural measure of attention control from the Attention Network Task (ANT); and (ii) anxiety and depression symptoms in two separate non-clinical samples (Ns = 165 and 193). Results of Study 1 indicated that only ACS focusing was significantly associated with ANT attention control; with both measures reflecting resistance to distraction. In both studies, self-reported ability to focus attention (ACS focusing) was associated with lower anxiety; and greater attentional flexibility (ACS shifting) was associated with fewer depression symptoms.
Aggressive variants of papillary thyroid cancer

Purpose of review Aggressive variants of papillary thyroid cancer (PTC) have been recognized with increasing frequency. The most common of these include the diffuse sclerosing variant, tall cell variant, and insular thyroid cancer. These tumors may represent a spectrum of dedifferentiation from classic PTC to anaplastic thyroid cancers. Recent findings Pathologists are reaching consensus in the diagnosis of these variants, recognizing their important distinction in clinical behavior. Preoperative studies such as ultrasonography, fine-needle aspiration, and better molecular and genetic markers help raise the suspicion of a thyroid nodule possibly harboring an aggressive cancer; this in turn allows the surgeons and endocrinologists to formulate a more complete operative plan, including thyroidectomy, possible lymphadenectomy, and postoperative radioactive iodine administration. In the past, most studies on these variants have relied on single institution and small clinical series; however, recent population-level analyses using national databases such as Surveillance, Epidemiology and End Result have included larger numbers of cases collected over many years. Summary These studies have allowed for the identification of temporal trends in tumor incidence, and long-term analyses of the clinical, pathological, and survival outcomes of patients with these aggressive variants.
Use of metformin is associated with lower incidence of cancer in patients with type 2 diabetes.

INTRODUCTION The objective of the study was to assess the influence of metformin on the prevalence of cancer and risk factors for the development of cancer, in patients with type 2 diabetes. MATERIALS AND METHODS A total of 1063 patients, treated between October 2012 and March 2013 in the Diabetes and Endocrinology Centre in Bydgoszcz, were enrolled in the study. Only patients who were first diagnosed with diabetes and consecutively with cancer were included in the analysis. The final dataset compromised data from 1028 patients with type 2 diabetes, in whom retrospective analysis of the association between the occurrence of cancer and treatment with or without metformin was performed. Demographic data, medical history, physical assessment, diabetes history, diabetes complications, concomitant medication, and additional examination results were compared between two groups: those with cancer and those without cancer. Data were analysed using Student's t-test, Chi-square test with Yates' continuity correction, and multiple logistic regression. RESULTS The most commonly observed cancer was breast cancer (24 patients; 22.5%), followed by uterine cancer (15 patients; 13.6%). Of the 75 diabetic patients with a cancer diagnosis, 18.7% were treated with metformin; of the 953 patients without cancer, 38% received metformin. Analysis of probability of cancer occurrence using Kaplan-Meier curves showed that the probability of cancer development was higher in groups of patients who were not treated with metformin (p = 0.006). CONCLUSIONS Metformin treatment reduces the risk of cancer in type 2 diabetes patients.
Factors Affecting the Immunity to Respiratory Syncytial Virus: From Epigenetics to Microbiome

Respiratory syncytial virus (RSV) is a common pathogen that infects virtually all children by 2 years of age and is the leading cause of hospitalization of infants worldwide. While most children experience mild symptoms, some children progress to severe lower respiratory tract infection. Those children with severe disease have a much higher risk of developing childhood wheezing later in life. Many risk factors are known to result in exacerbated disease, including premature birth and early age of RSV infection, when the immune system is relatively immature. The development of the immune system before and after birth may be altered by several extrinsic and intrinsic factors that could lead to severe disease predisposition in children who do not exhibit any currently known risk factors. Recently, the role of the microbiome and the resulting metabolite profile has been an area of intense study in the development of lung disease, including viral infection and asthma. This review explores both known risk factors that can lead to severe RSV-induced disease as well as emerging topics in the development of immunity to RSV and the long-term consequences of severe infection.
Interleukin-1 Receptor 2: A New Biomarker for Sepsis Diagnosis and Gram-Negative/Gram-Positive Bacterial Differentiation

ABSTRACT This study was undertaken to explore the value of interleukin-1 receptor 2 (IL1R2) as a novel potential biomarker for diagnosis of sepsis and discrimination of gram-negative (G−)/gram-positive (G+) bacterial sepsis. The study was performed in Kunming mice and septic patients. Inactive Escherichia coli or Staphylococcus aureus were used to stimulate Kunming mice (109 CFU/kg). In clinical study, septic patients with different pathogen infection were studied, and healthy volunteers and patients with systemic inflammatory response syndrome without definite infection were enrolled as control. IL1R2 transcriptions of human subjects’ peripheral leukocytes were measured by real-time quantitative polymerase chain reaction assay. IL1R2 serum concentrations of mice and human subjects were measured by enzyme-linked immunosorbent assay. The value of IL1R2 as a biomarker was compared with procalcitonin (PCT), C-reactive protein (CRP), and Acute Physiology and Chronic Health Evaluation II (APACHE II). The results showed that IL1R2 expression was upregulated in mice treated with inactive Escherichia coli and septic patients. The elevation of serum IL1R2 was more significant in septic patients infected by Escherichia coli or G− bacteria than in those infected by Staphylococcus aureus or G+ bacteria. For sepsis diagnosis and G−/G+ bacterial sepsis discrimination, serum IL1R2 was more sensitive and specific than the traditional biomarkers such as PCT, CRP, and APACHE II as shown by the receiver operating characteristic curves. It was suggested that IL1R2 was a potential biomarker for diagnosis and G−/G+ bacterial differentiation in sepsis.
Ethical frameworks for surrogates’ end-of-life planning experiences

Background: Despite the growing body of knowledge about surrogate decision making, we know very little about the use of ethical frameworks (including ethical theories, principles, and concepts) to understand surrogates’ day-to-day experiences in end-of-life care planning for incapacitated adults. Objectives and Methods: This qualitative systematic review was conducted to identify the types of ethical frameworks used to address surrogates’ experiences in end-of-life care planning for incapacitated adults as well as the most common themes or patterns found in surrogate decision-making research. Findings: Seven research papers explicitly identified ethical theories, principles, or concepts, such as autonomy, substituted judgment, and best interest standards as guidelines for the research. Surrogate decision making themes included the responsibilities and goals of being a surrogate, factors influencing surrogates’ decision making, outcomes for surrogates, and an overarching theme of “wanting to do the right thing” for their loved one and/or themselves. Discussion: Understanding the complexity of surrogates’ experiences of end-of-life care planning is beyond the scope of conventional ethical frameworks. Conclusion: Ethical frameworks that address individuality and contextual variations related to decision making may more appropriately guide surrogate decision-making research that explores surrogates’ end-of-life care planning experiences.
NIDO, AMOP and vWD domains of MUC4 play synergic role in MUC4 mediated signaling

MUC4 mucin is well known as an important potential target to overcome pancreatic cancer. Three unique domains (NIDO, AMOP, and vWD) with unclear roles only present in MUC4 but are not found in other membrane-bound mucins. Our previous studies first reported that its splice variant, MUC4/Y can be a model of MUC4 (MUC4 gene fragment is more than 30KB, too huge to clone and eukaryotic express) in pancreatic cancer. More importantly, based on MUC4/Y with the appropriate length of gene sequence, it is easy to construct the unique domain-lacking models of MUC4/Y (MUC4) for research. The present study focuses on investigation of the respective role of the unique NIDO, AMOP, and vWD domain or their synergistic effect on MUC4(MUC4/Y)-mediated functions and mechanisms by series of in vitro assays, sequence-based transcriptome analysis, validation of qRT-PCR & Western blot, and systematic comparative analysis. Our results demonstrate: 1) NIDO, AMOP, and vWD domain or their synergy play significant roles on MUC4/Y-mediated malignant function of pancreatic cancer, downstream of molecule mechanisms, particularly MUC4/Y-triggered malignancy-related positive feedback loops, respectively. 2) The synergistic roles of three unique domains on MUC4/Y-mediated functions and mechanisms are more prominent than the respective domain because the synergy of three domain plays the more remarkable effects on MUC4/Y-mediated signaling hub. Thus, to improve reversed effects of domain-lacking and break the synergism of domains will contribute to block MUC4/Y(MUC4) triggering various oncogenic signaling pathways.
Improving anticancer drug development begins with cell culture: misinformation perpetrated by the misuse of cytotoxicity assays

The high failure rate of anticancer drug discovery and development has consumed billions of dollars annually. While many explanations have been provided, I believe that misinformation arising from inappropriate cell-based screens has been completely over-looked. Most cell culture experiments are irrelevant to how drugs are subsequently administered to patients. Usually, drug development focuses on growth inhibition rather than cell killing. Drugs are selected based on continuous incubation of cells, then frequently administered to the patient as a bolus. Target identification and validation is often performed by gene suppression that inevitably mimics continuous target inhibition. Drug concentrations in vitro frequently far exceed in vivo concentrations. Studies of drug synergy are performed at sub-optimal concentrations. And the focus on a limited number of cell lines can misrepresent the potential efficacy in a patient population. The intent of this review is to encourage more appropriate experimental design and data interpretation, and to improve drug development in the area of cell-based assays. Application of these principles should greatly enhance the successful translation of novel drugs to the patient.
Patent Foramen Ovale Closure or Antiplatelet Therapy for Cryptogenic Stroke

BACKGROUND The efficacy of closure of a patent foramen ovale (PFO) in the prevention of recurrent stroke after cryptogenic stroke is uncertain. We investigated the effect of PFO closure combined with antiplatelet therapy versus antiplatelet therapy alone on the risks of recurrent stroke and new brain infarctions. METHODS In this multinational trial involving patients with a PFO who had had a cryptogenic stroke, we randomly assigned patients, in a 2:1 ratio, to undergo PFO closure plus antiplatelet therapy (PFO closure group) or to receive antiplatelet therapy alone (antiplatelet‐only group). Imaging of the brain was performed at the baseline screening and at 24 months. The coprimary end points were freedom from clinical evidence of ischemic stroke (reported here as the percentage of patients who had a recurrence of stroke) through at least 24 months after randomization and the 24‐month incidence of new brain infarction, which was a composite of clinical ischemic stroke or silent brain infarction detected on imaging. RESULTS We enrolled 664 patients (mean age, 45.2 years), of whom 81% had moderate or large interatrial shunts. During a median follow‐up of 3.2 years, clinical ischemic stroke occurred in 6 of 441 patients (1.4%) in the PFO closure group and in 12 of 223 patients (5.4%) in the antiplatelet‐only group (hazard ratio, 0.23; 95% confidence interval [CI], 0.09 to 0.62; P=0.002). The incidence of new brain infarctions was significantly lower in the PFO closure group than in the antiplatelet‐only group (22 patients [5.7%] vs. 20 patients [11.3%]; relative risk, 0.51; 95% CI, 0.29 to 0.91; P=0.04), but the incidence of silent brain infarction did not differ significantly between the study groups (P=0.97). Serious adverse events occurred in 23.1% of the patients in the PFO closure group and in 27.8% of the patients in the antiplatelet‐only group (P=0.22). Serious device‐related adverse events occurred in 6 patients (1.4%) in the PFO closure group, and atrial fibrillation occurred in 29 patients (6.6%) after PFO closure. CONCLUSIONS Among patients with a PFO who had had a cryptogenic stroke, the risk of subsequent ischemic stroke was lower among those assigned to PFO closure combined with antiplatelet therapy than among those assigned to antiplatelet therapy alone; however, PFO closure was associated with higher rates of device complications and atrial fibrillation. (Funded by W.L. Gore and Associates; Gore REDUCE ClinicalTrials.gov number, NCT00738894.)
Role of anti‐domain 1‐β2glycoprotein I antibodies in the diagnosis and risk stratification of antiphospholipid syndrome

Essentials Antibodies to domain 1 of β2 glycoprotein I (aD1) are a subset of antiphospholipid antibodies. We evaluated the added diagnostic value of an automated aD1 assay in antiphospholipid syndrome. AD1 IgG correctly classifies patients at risk for thrombosis. Agreement between aD1 and aβ2GPI IgG is high, limiting the added value of aD1 in our setting.
Limbal Stem Cell Transplantation and Complications

ABSTRACT Corneal epithelial stem cells are adult somatic stem cells located at the limbus and represent the ultimate source of transparent corneal epithelium. When these limbal stem cells become dysfunctional or deficient, limbal stem cell deficiency (LSCD) develops. LSCD is a major cause of corneal scarring and is particularly prevalent in chemical and thermal burns of the ocular surface. LSCD leads to conjunctivalization of the corneal surface, neovascularization, recurrent or persistent epithelial defects, ocular surface inflammation, and scarring that, in turn, lead to decreased vision, pain, and impaired quality of life. Several techniques have been reported for limbal stem cell transplantation (LSCT). We introduce the surgical techniques, examine the success rate, and discuss the postoperative complications of conjunctival limbal autograft (CLAU), cultivated limbal stem cell transplantation (CLET), simple limbal epithelial transplantation (SLET), and limbal allograft, including keratolimbal allografts (KLAL) and living-related conjunctival allograft (LR-CLAL).
Condition Monitoring in Advanced Battery Management Systems: Moving Horizon Estimation Using a Reduced Electrochemical Model

Efficient battery condition monitoring is of particular importance in large-scale, high-performance, and safety-critical mechatronic systems, e.g., electrified vehicles and smart grid. This paper pursues a detailed assessment of optimization-driven moving horizon estimation (MHE) framework by means of a reduced electrochemical model. For state-of-charge estimation, the standard MHE and two variants in the framework are examined by a comprehensive consideration of accuracy, computational intensity, effect of horizon size, and fault tolerance. A comparison with common extended Kalman filtering and unscented Kalman filtering is also carried out. Then, the feasibility and performance are demonstrated for accessing internal battery states unavailable in equivalent circuit models, such as solid-phase surface concentration and electrolyte concentration. Ultimately, a multiscale MHE-type scheme is created for State-of-Health estimation. This study is the first known systematic investigation of MHE-type estimators applied to battery management.
Refining Word Embeddings for Sentiment Analysis

Word embeddings that can capture semantic and syntactic information from contexts have been extensively used for various natural language processing tasks. However, existing methods for learning context-based word embeddings typically fail to capture sufficient sentiment information. This may result in words with similar vector representations having an opposite sentiment polarity (e.g., good and bad), thus degrading sentiment analysis performance. Therefore, this study proposes a word vector refinement model that can be applied to any pre-trained word vectors (e.g., Word2vec and GloVe). The refinement model is based on adjusting the vector representations of words such that they can be closer to both semantically and sentimentally similar words and further away from sentimentally dissimilar words. Experimental results show that the proposed method can improve conventional word embeddings and outperform previously proposed sentiment embeddings for both binary and fine-grained classification on Stanford Sentiment Treebank (SST).
Dietary Vitamin D Intake Among High-Risk Adolescents With Insulin Dependent Diabetes

Purpose The purpose of the present study was to describe the dietary intake of vitamin D in an urban, low income, predominantly African American sample of adolescents with insulin dependent diabetes. Methods Participants were 99 adolescents diagnosed with insulin dependent diabetes. Vitamin D intake was estimated from dietary recall data. Blood glucose levels were also assessed. Results The average daily vitamin D intake estimated from dietary recall data was 102 IUs (SD = 64.4) with 70% of adolescents consuming less than 50 IUs of vitamin D in their day. Level of vitamin D intake was a significant predictor of HbA1c levels in the current sample. Conclusions Results indicate a need for the assessment of vitamin D levels in this at-risk population, as supplementation may be indicated.