Miracle-dz/UniFAR-FTUs huggingface dataset:
The Association between Metabolic Syndrome, Bone Mineral Density, Hip Bone Geometry and Fracture Risk: The Rotterdam Study

The association between metabolic syndrome (MS) and bone health remains unclear. We aimed to study the association between MS and hip bone geometry (HBG), femoral neck bone mineral density (FN-BMD), and the risk of osteoporosis and incident fractures. Data of 2040 women and 1510 men participants in the third visit (1997–1999) of the Rotterdam Study (RSI-3), a prospective population based cohort, were available (mean follow-up 6.7 years). MS was defined according to the recent harmonized definition. HBG parameters were measured at the third round visit whereas FN-BMD was assessed at the third round and 5 years later. Incident fractures were identified from medical registry data. After correcting for age, body mass index (BMI), lifestyle factors and medication use, individuals with MS had lower bone width (β = -0.054, P = 0.003), lower cortical buckling ratio (β = -0.81, P = 0.003) and lower odds of having osteoporosis (odds ratio =0.56, P = 0.007) in women but not in men. Similarly, MS was associated with higher FN-BMD only in women (β = 0.028, P=0.001). In the analyses of MS components, the glucose component (unrelated to diabetes status) was positively associated with FN-BMD in both genders (β = 0.016, P = 0.01 for women and β = 0.022, P = 0.004 for men). In men, waist circumference was inversely associated with FN-BMD (β = -0.03, P = 0.004). No association was observed with fracture risk in either sex. In conclusion, women with MS had higher FN-BMD independent of BMI. The glucose component of MS was associated with high FN-BMD in both genders, highlighting the need to preserve glycemic control to prevent skeletal complications.
Mycolactone-mediated neurite degeneration and functional effects in cultured human and rat DRG neurons

Background Mycolactone is a polyketide toxin secreted by the mycobacterium Mycobacterium ulcerans, responsible for the extensive hypoalgesic skin lesions characteristic of patients with Buruli ulcer. A recent pre-clinical study proposed that mycolactone may produce analgesia via activation of the angiotensin II type 2 receptor (AT2R). In contrast, AT2R antagonist EMA401 has shown analgesic efficacy in animal models and clinical trials for neuropathic pain. We therefore investigated the morphological and functional effects of mycolactone in cultured human and rat dorsal root ganglia (DRG) neurons and the role of AT2R using EMA401. Primary sensory neurons were prepared from avulsed cervical human DRG and rat DRG; 24 h after plating, neurons were incubated for 24 to 96 h with synthetic mycolactone A/B, followed by immunostaining with antibodies to PGP9.5, Gap43, β tubulin, or Mitotracker dye staining. Acute functional effects were examined by measuring capsaicin responses with calcium imaging in DRG neuronal cultures treated with mycolactone. Results Morphological effects: Mycolactone-treated cultures showed dramatically reduced numbers of surviving neurons and non-neuronal cells, reduced Gap43 and β tubulin expression, degenerating neurites and reduced cell body diameter, compared with controls. Dose-related reduction of neurite length was observed in mycolactone-treated cultures. Mitochondria were distributed throughout the length of neurites and soma of control neurons, but clustered in the neurites and soma of mycolactone-treated neurons. Functional effects: Mycolactone-treated human and rat DRG neurons showed dose-related inhibition of capsaicin responses, which were reversed by calcineurin inhibitor cyclosporine and phosphodiesterase inhibitor 3-isobutyl-1-Methylxanthine, indicating involvement of cAMP/ATP reduction. The morphological and functional effects of mycolactone were not altered by Angiotensin II or AT2R antagonist EMA401. Conclusion Mycolactone induces toxic effects in DRG neurons, leading to impaired nociceptor function, neurite degeneration, and cell death, resembling the cutaneous hypoalgesia and nerve damage in individuals with M. Ulcerans infection.
NORDCAN – a Nordic tool for cancer information, planning, quality control and research

Abstract The NORDCAN database and program (www.ancr.nu) include detailed information and results on cancer incidence, mortality and prevalence in each of the Nordic countries over five decades and has lately been supplemented with predictions of cancer incidence and mortality; future extensions include the incorporation of cancer survival estimates. Material and methods. The data originates from the national cancer registries and causes of death registries in Denmark, Finland, Iceland, Norway, Sweden, and Faroe Islands and is regularly updated. Presently 41 cancer entities are included in the common dataset, and conversions of the original national data according to international rules ensure comparability. Results. With 25 million inhabitants in the Nordic countries, 130 000 incident cancers are reported yearly, alongside nearly 60 000 cancer deaths, with almost a million persons living with a cancer diagnosis. This web-based application is available in English and in each of the five Nordic national languages. It includes comprehensive and easy-to-use descriptive epidemiology tools that provide tabulations and graphs, with further user-specified options available. Discussion. The NORDCAN database aims to provide comparable and timely data to serve the varying needs of policy makers, cancer societies, the public, and journalists, as well as the clinical and research community.
Pin1-Nanog expression in human glioma is correlated with advanced tumor progression

The stemness gene Nanog has been shown to play an important role in tumor development, including glioma. Nanog is phosphorylated at multiple Ser/Thr-Pro motifs, which promotes the interaction between Nanog and the prolyl isomerase Pin1, leading to Nanog stabilization by suppressing its ubiquitination. The present study investigated the expression and relationship of Pin1 and Nanog in human gliomas. Significantly higher mRNA and protein expression levels of Pin1 and Nanog were demonstrated in 120 glioma specimens of different pathological grades by RT-PCR, immunohistochemistry staining and western blot analysis. The relative levels of Pin1 expression, as well as Nanog expression, were significantly positively correlated with pathological grade. Moreover, a positive correlation of Pin1 and Nanog expression in human gliomas was noted. Co-localization of Pin1 and Nanog was observed in the perinuclear space in the cytoplasm of glioma cells detected by immunofluorescence staining. Significantly positive correlation between Pin1 and Nanog in gliomas indicated that Pin1 and Nanog may be related to tumorigenesis and development of glioma cells.
Depression in Medical In-Patients

Although there have been many accounts of depression in medical in-patients, there have been relatively few systematic studies of its prevalence and features. With respect to prevalence, most studies have concerned single medical diagnoses (4) or have been based on ward referrals to psychiatrists, in which referral practices may be of more importance than actual occurrences (10). Schwab et al. (12, 13) studied prevalence in 153 medical patients. They used multiple rating scales and compared depressed and non-depressed patients to investigate aetiological factors. Stewart et al. (14), who carried out a smaller study, also compared symptoms of five medical depressives with those of manic depressives.
Multilevel Threshold Based Gray Scale Image Segmentation using Cuckoo Search

Abstract Image Segmentation is a technique of partitioning the original image into some distinct classes. Many possible solutions may be available for segmenting an image into a certain number of classes, each one having different quality of segmentation. In our proposed method, multilevel thresholding technique has been used for image segmentation. A new approach of Cuckoo Search (CS) is used for selection of optimal threshold value. In other words, the algorithm is used to achieve the best solution from the initial random threshold values or solutions and to evaluate the quality of a solution correlation function is used. Finally, MSE and PSNR are measured to understand the segmentation quality. Keywords : Multilevel Image Segmentation, Correlation, Cuckoo Search, PSNR. 1. Introduction Image segmentation has a major importance in digital image processing. Image segmentation is actually the process of subdividing an image into its constituent regions or objects based on shape, colour, position, texture and homogeneity of image regions. In mathematical sense, the segmentation of image I, which is a set of pixels, is the partition of I into n disjoint sets M
Internally deterministic parallel algorithms can be fast

The virtues of deterministic parallelism have been argued for decades and many forms of deterministic parallelism have been described and analyzed. Here we are concerned with one of the strongest forms, requiring that for any input there is a unique dependence graph representing a trace of the computation annotated with every operation and value. This has been referred to as internal determinism, and implies a sequential semantics---i.e., considering any sequential traversal of the dependence graph is sufficient for analyzing the correctness of the code. In addition to returning deterministic results, internal determinism has many advantages including ease of reasoning about the code, ease of verifying correctness, ease of debugging, ease of defining invariants, ease of defining good coverage for testing, and ease of formally, informally and experimentally reasoning about performance. On the other hand one needs to consider the possible downsides of determinism, which might include making algorithms (i) more complicated, unnatural or special purpose and/or (ii) slower or less scalable. In this paper we study the effectiveness of this strong form of determinism through a broad set of benchmark problems. Our main contribution is to demonstrate that for this wide body of problems, there exist efficient internally deterministic algorithms, and moreover that these algorithms are natural to reason about and not complicated to code. We leverage an approach to determinism suggested by Steele (1990), which is to use nested parallelism with commutative operations. Our algorithms apply several diverse programming paradigms that fit within the model including (i) a strict functional style (no shared state among concurrent operations), (ii) an approach we refer to as deterministic reservations, and (iii) the use of commutative, linearizable operations on data structures. We describe algorithms for the benchmark problems that use these deterministic approaches and present performance results on a 32-core machine. Perhaps surprisingly, for all problems, our internally deterministic algorithms achieve good speedup and good performance even relative to prior nondeterministic solutions.
In Situ Observations during Chemical Vapor Deposition of Hexagonal Boron Nitride on Polycrystalline Copper

Using a combination of complementary in situ X-ray photoelectron spectroscopy and X-ray diffraction, we study the fundamental mechanisms underlying the chemical vapor deposition (CVD) of hexagonal boron nitride (h-BN) on polycrystalline Cu. The nucleation and growth of h-BN layers is found to occur isothermally, i.e., at constant elevated temperature, on the Cu surface during exposure to borazine. A Cu lattice expansion during borazine exposure and B precipitation from Cu upon cooling highlight that B is incorporated into the Cu bulk, i.e., that growth is not just surface-mediated. On this basis we suggest that B is taken up in the Cu catalyst while N is not (by relative amounts), indicating element-specific feeding mechanisms including the bulk of the catalyst. We further show that oxygen intercalation readily occurs under as-grown h-BN during ambient air exposure, as is common in further processing, and that this negatively affects the stability of h-BN on the catalyst. For extended air exposure Cu oxidation is observed, and upon re-heating in vacuum an oxygen-mediated disintegration of the h-BN film via volatile boron oxides occurs. Importantly, this disintegration is catalyst mediated, i.e., occurs at the catalyst/h-BN interface and depends on the level of oxygen fed to this interface. In turn, however, deliberate feeding of oxygen during h-BN deposition can positively affect control over film morphology. We discuss the implications of these observations in the context of corrosion protection and relate them to challenges in process integration and heterostructure CVD.
Fault localization using forward slicing spectrum

An increase in the cost incurred during manual software testing, debugging process and the requirement for reliable test data have forced the researchers to develop an automated system for software fault localization. We have proposed a forward slicing spectrum for fault localization. The proposed approach alleviates some of the core issues of standalone fault localization techniques such as program slicing and program spectrum based methods.
The concept of creativity and its synonyms and antonyms retrieved by a free association study

As part of the EU project Concept Creation Technology we want to investigate the concept of creativity, because it is still unclear what creativity really means and how it can be evaluated in computer systems. Jordanous (2012) has made an attempt to analyze the concept of creativity in the scientific literature and to evaluate it. The result of her research was a list of 694 words which might be related to creativity. This study investigates to what extent people associate a selection of 32 words from her list and words from this study back to creativity. 50 students took part in a free association study, where the synonyms and antonyms of the words also had to be named. 29 words have been associated with the concept of creativity, seven of those words have been only mentioned by Jordanous (2012). We also found that demographic variables influence the answers on the synonyms. In the end a proposal for how to evaluate creativity in computer systems is given.
Soil, plant, and transport influences on methane in a subalpine forest under high ultraviolet irradiance

Abstract. Recent studies have demonstrated direct methane emission from plant foliage under aerobic conditions, particularly under high ultraviolet (UV) irradiance. We examined the potential importance of this phenomenon in a high-elevation conifer forest using micrometeorological techniques. Vertical profiles of methane and carbon dioxide in forest air were monitored every 2 h for 6 weeks in summer 2007. Day to day variability in above-canopy CH4 was high, with observed values in the range 1790 to 1910 nmol mol−1. High CH4 was correlated with high carbon monoxide and related to wind direction, consistent with pollutant transport from an urban area by a well-studied mountain-plain wind system. Soils were moderately dry during the study. Vertical gradients of CH4 were small but detectable day and night, both near the ground and within the vegetation canopy. Gradients near the ground were consistent with the forest soil being a net CH4 sink. Using scalar similarity with CO2, the magnitude of the summer soil CH4 sink was estimated at ~1.7 mg CH4 m−2 h−1, which is similar to other temperate forest upland soils. The high-elevation forest was naturally exposed to high UV irradiance under clear sky conditions, with observed peak UVB irradiance >2 W m−2. Gradients and means of CO2 within the canopy under daytime conditions showed net uptake of CO2 due to photosynthetic drawdown as expected. No evidence was found for a significant foliar CH4 source in the vegetation canopy, even under high UV conditions. While the possibility of a weak foliar source cannot be excluded given the observed soil sink, overall this subalpine forest was a net sink for atmospheric methane during the growing season.
Short-length rateless codes with unequal error protection property

In some special applications, the importance of different parts of a file to be transmitted such as video or picture is different and the important part (such as the format part) need be given prior protection. This is called unequal error protection (UEP). In this paper we propose a new coding scheme which can provide UEP by cascading new short-length rateless codes with RS codes. In our proposed UEP coding scheme, the decoding success probability of the important data parts are improved by participating in two encoding processes. We theoretically analyzed the decoding failure bound of our UEP coding scheme and confirmed the effectiveness of our method by numerical experiments. Experimental results showed that even the code length is small, our UEP coding scheme can also realize unequal error protection under very small decoding overhead.
EXPLOSIVE DISINTEGRATION OF A MASSIVE YOUNG STELLAR SYSTEM IN ORION

Young massive stars in the center of crowded star clusters are expected to undergo close dynamical encounters that could lead to energetic, explosive events. However, there has so far never been clear observational evidence of such a remarkable phenomenon. We here report new interferometric observations that indicate the well-known enigmatic wide-angle outflow located in the Orion BN/KL star-forming region to have been produced by such a violent explosion during the disruption of a massive young stellar system, and that this was caused by a close dynamical interaction about 500 years ago. This outflow thus belongs to a totally different family of molecular flows that is not related to the classical bipolar flows that are generated by stars during their formation process. Our molecular data allow us to create a three-dimensional view of the debris flow and to link this directly to the well-known Orion H2 “fingers” farther out.
Costly interactions between the sexes: combined effects of male sexual harassment and female choice?

Male and female interests can differ profoundly regarding quality and quantity of mates. Especially in promiscuous mating systems, males often inflict costs on females that may precipitate in negative fitness consequences. In reality, however, discerning between female costs arising from a sexual conflict and costs arising from female mate choice is not trivial. In livebearing fishes, for example, costs of male sexual harassment are often quantified as female feeding time reductions, but female feeding times may also be affected by competitive interactions and the willingness of females to interact with a particular mate (i.e., mate choice). Using the tropical live-bearer Poecilia mexicana as a model, we manipulated male and female nutritional state and measured focal females' feeding times in presence of another female as well as in presence of males of varying quality. Consistent with other studies quantifying effects of male harassment, female feeding times were negatively affected by sexually active males. Also, females were feeding more in presence of starved males than in presence of well-fed males. In subsequent dichotomous choice tests, females preferred to associate with well-fed females. These results are not consistent with the sexual conflict hypothesis: If the reduced female feeding time in presence of a well-fed male were solely a cost imposed by the male, females would be expected to avoid such males in a choice situation. Consequently, our study suggests that both male sexual harassment and active female choice simultaneously affect female feeding times in livebearing fishes. Copyright 2011, Oxford University Press.
Control-fluidic codesign for paper-based digital microfluidic biochips

Paper-based digital microfluidic biochips (P-DMFBs) have recently emerged as a promising low-cost and fast-responsive platform for biochemical assays. In P-DMFBs, electrodes and control lines are printed on a piece of photo paper using inkjet printer and conductive ink of carbon nanotubes (CNTs). Compared with traditional digital microfluidic biochips (DMFBs), P-DMFBs enjoy notable advantages, such as faster in-place fabrication with printer and ink, lower costs, better disposability, etc. Because electrodes and CNT control lines are printed on the same side of a paper, a new design challenge for P-DMFB is to prevent the interference between moving droplets and the voltages on CNT control lines. These interactions may result in unexpected droplet movements and thus incorrect assay outputs. To address the new challenges in automated design of P-DMFBs, this paper proposes the first control-fluidic codesign flow, which simultaneously adjusts the control line routing and fluidic droplet scheduling to achieve an optimized solution. As the control line routing may not be able to address all the interferences between moving droplets and the voltages on control lines, droplet rescheduling is performed to effectively deal with the remaining interferences in the routing solution. Computational simulation results on real-life bioassays show that the proposed codesign method successfully eliminates all the interferences, while a state-of-the-art maze routing method cannot solve any of the benchmarks without conflicts.
Distortion-transmission trade-off in real-time transmission of Gauss-Markov sources

The problem of optimal real-time transmission of a Gauss-Markov source under constraints on the expected number of transmissions is considered. This setup is motivated by applications where transmission is sporadic and the cost of switching on the radio and transmitting is significantly more important than the size of the transmitted data packet. The structure of optimal transmission and estimation strategies had been established in the literature. We use these structural results to determine the distortion-transmission function, i.e., the minimum expected distortion that can be achieved when the expected number of transmissions is less than or equal to a particular value. We characterize how the distortion-transmission function scales with the variance of the source and show that it can be computed numerically by solving two Fredholm integral equations of the second kind.
Time-frequency-tuned salient region detection and segmentation

The present paper describes an efficient method for detecting and segmenting salient region(s) in an image. The method uses a time-frequency tuned salient region extraction technique based on wavelet transform (WT). WT provides both spatial and spectral characteristics (i.e., texture information) of pixels and hence can be utilized effectively for improving quality of salient region detection. As a result, the proposed method generates full resolution maps with uniformly highlighted regions with well defined boundaries, and invariant to translation, rotation and scaling that make it more useful in applications like object segmentation / recognition and adaptive compression. The superiority of the proposed method over the existing, is demonstrated both qualitatively and quantitatively using the indexes like precision and recall with a large set of benchmark data sets.