Miracle-dz/UniFAR-FTUs huggingface dataset:
First Results from CUORE: A Search for Lepton Number Violation via 0νββ Decay of ^{130}Te.

The CUORE experiment, a ton-scale cryogenic bolometer array, recently began operation at the Laboratori Nazionali del Gran Sasso in Italy. The array represents a significant advancement in this technology, and in this work we apply it for the first time to a high-sensitivity search for a lepton-number-violating process: ^{130}Te neutrinoless double-beta decay. Examining a total TeO_{2} exposure of 86.3 kg yr, characterized by an effective energy resolution of (7.7±0.5) keV FWHM and a background in the region of interest of (0.014±0.002) counts/(keV kg yr), we find no evidence for neutrinoless double-beta decay. Including systematic uncertainties, we place a lower limit on the decay half-life of T_{1/2}^{0ν}(^{130}Te)>1.3×10^{25} yr (90% C.L.); the median statistical sensitivity of this search is 7.0×10^{24} yr. Combining this result with those of two earlier experiments, Cuoricino and CUORE-0, we find T_{1/2}^{0ν}(^{130}Te)>1.5×10^{25} yr (90% C.L.), which is the most stringent limit to date on this decay. Interpreting this result as a limit on the effective Majorana neutrino mass, we find m_{ββ}<(110-520) meV, where the range reflects the nuclear matrix element estimates employed.
Volumetric changes following ridge preservation or spontaneous healing and early implant placement with simultaneous guided bone regeneration

AIM To assess volumetric and linear changes following ridge preservation (RP) or spontaneous healing plus early implant placement with or without simultaneous guided bone regeneration (GBR). MATERIALS AND METHODS In eight adult beagle dogs, the mesial roots of the mandibular P3, P4 and M1 were extracted. Sites were randomized to either ridge preservation (RP) or spontaneous healing (SH). Four weeks later dental implants were placed either with (RP2) or without removing non-integrated DBBM (RP1). In RP2 and SH sites, GBR was applied using a demineralized bovine bone mineral and a resorbable membrane. Impressions were taken postextraction (SH)/postridge preservation (RP1; RP2), before and after implant placement and after healing of 4 and 12 weeks. Casts were digitized to allow for superimposition and measurement of contour alterations. RESULTS Median ridge width reduction from postextraction (SH)/postridge preservation (RP1;RP2) to implant placement ranged from -13.9% (SH) to -19.7% (RP) (p > .05), whereas from implant placement to sacrifice, it was statistically significantly lower in group RP1 (-5.5%) compared to group SH (-23.4%; p = .0013) and group RP2 (-22.1%; p = .0026). Encompassing the entire study period, median ridge width changes ranged between -17.8% (SH), -24.8% (RP2) and -32.5% (RP1) (p > .05). CONCLUSIONS Irrespective of the treatment modality and the healing period, part of the ridge contour was lost. Early implant placement after ridge preservation without additional GBR resulted in a more stable ridge contour after implant placement compared to controls.
Staging lung cancer: role of endobronchial ultrasound

Accurate staging is the first step in the management of lung cancer. Nodal staging is quite important for physicians to be able to judge the primary operability of patients harboring no distant metastasis. For many years, mediastinoscopy has been considered a “gold standard” modality for nodal staging. Mediastinoscopy is known to be a highly sensitive procedure for mediastinal staging and has been performed worldwide, but is invasive. Because of this, clinicians have sought a less invasive modality for nodal staging. Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a minimally invasive modality for diagnosis and staging of lung cancer. EBUS-TBNA is a needle biopsy procedure that has accessibility compatible with the reach of the convex-probe EBUS scope, so N1 nodes are also assessable. The diagnostic yield is similar to that of mediastinoscopy, and the core obtained by the dedicated needle biopsy can be used for histological assessment to determine the subtypes of lung cancer. The samples can also be used to test for various biomarkers using immunohistochemistry, polymerase chain reaction for DNA/complementary DNA, and in situ hybridization, and the technique is useful for selecting candidates for specific molecular-targeted therapeutic agents. According to the newly published American College of Chest Physicians guideline, EBUS-TBNA is now considered “the best first test” for nodal staging in patients with radiologically suspicious nodes. Appropriate training and thorough clinical experience is required to be able to perform correct nodal staging using this procedure.
Enquiring Minds: Early Detection of Rumors in Social Media from Enquiry Posts

Many previous techniques identify trending topics in social media, even topics that are not pre-defined. We present a technique to identify trending rumors, which we define as topics that include disputed factual claims. Putting aside any attempt to assess whether the rumors are true or false, it is valuable to identify trending rumors as early as possible. It is extremely difficult to accurately classify whether every individual post is or is not making a disputed factual claim. We are able to identify trending rumors by recasting the problem as finding entire clusters of posts whose topic is a disputed factual claim. The key insight is that when there is a rumor, even though most posts do not raise questions about it, there may be a few that do. If we can find signature text phrases that are used by a few people to express skepticism about factual claims and are rarely used to express anything else, we can use those as detectors for rumor clusters. Indeed, we have found a few phrases that seem to be used exactly that way, including: "Is this true? ", "Really? ", and "What? ". Relatively few posts related to any particular rumor use any of these enquiry phrases, but lots of rumor diffusion processes have some posts that do and have them quite early in the diffusion. We have developed a technique based on searching for the enquiry phrases, clustering similar posts together, and then collecting related posts that do not contain these simple phrases. We then rank the clusters by their likelihood of really containing a disputed factual claim. The detector, which searches for the very rare but very informative phrases, combined with clustering and a classifier on the clusters, yields surprisingly good performance. On a typical day of Twitter, about a third of the top 50 clusters were judged to be rumors, a high enough precision that human analysts might be willing to sift through them.
Developmental trends of hot and cool executive function in school-aged children with and without autism spectrum disorder: Links with theory of mind

Abstract The development of executive function (EF) in autism spectrum disorder (ASD) has been investigated using only “cool”-cognitive EF tasks while there is limited knowledge regarding the development of “hot”-affective EF. Although cool EF development and its links to theory of mind (ToM) have been widely examined, understanding of the influence of hot EF to ToM mechanisms is minimal. The present study introduced a longitudinal design to examine the developmental changes in cool and hot EF of children with ASD (n = 45) and matched (to age and IQ) controls (n = 37) as well as the impact of EF on ToM development over a school year. For children with ASD, although selective cool (working memory and inhibition) and hot (affective decision making) EF domains presented age-related improvements, they never reached the performance level of the control group. Early cool working memory predicted later ToM in both groups but early hot delay discounting predicted later ToM only in the ASD group. No evidence was found for the reverse pattern (early ToM predicting later EF). These findings suggest that improvements in some EF aspects are evident in school age in ASD and highlight the crucial role that both cool and hot EF play in ToM development.
Dynamic Distribution of Strain in Textile Materials Under High-Speed Impact

of a body armour material, the various modes of energy absorption must he. determined. These evaluations must be related to the lr.t,ir textile nber material, the structure of the yarn. and the interaction of yarn behavior in a complex multilayer wovea fabric mass. To determine the behavior of such materials to the impact of a high-speed projectile (fragment simulator I, it was necessary to develop high-speed techniques for direct observation of the impact. j listorically, this investigation was initiated by the development of a new and complex weave for body armour materials by the Canadian Directorate of Ittterservice Development, evaluation of this B11aterial in 1954, together with the standard 2 x 2 basket weave used in the U. S. Army nylon body-
ERS statement on protracted bacterial bronchitis in children

This European Respiratory Society statement provides a comprehensive overview on protracted bacterial bronchitis (PBB) in children. A task force of experts, consisting of clinicians from Europe and Australia who manage children with PBB determined the overall scope of this statement through consensus. Systematic reviews addressing key questions were undertaken, diagrams in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement constructed and findings of relevant studies summarised. The final content of this statement was agreed upon by all members. The current knowledge regarding PBB is presented, including the definition, microbiology data, known pathobiology, bronchoalveolar lavage findings and treatment strategies to manage these children. Evidence for the definition of PBB was sought specifically and presented. In addition, the task force identified several major clinical areas in PBB requiring further research, including collecting more prospective data to better identify the disease burden within the community, determining its natural history, a better understanding of the underlying disease mechanisms and how to optimise its treatment, with a particular requirement for randomised controlled trials to be conducted in primary care. ERS task force reviews evidence and suggests future research for protracted bacterial bronchitis in children http://ow.ly/KDtV30dbmGH
Evolution of Neutralization Response in HIV-1 Subtype C-Infected Individuals Exhibiting Broad Cross-Clade Neutralization of HIV-1 Strains

Strain-specific neutralizing antibodies develop in all human immunodeficiency virus type 1 (HIV-1)-infected individuals. However, only 10–30% of infected individuals produce broadly neutralizing antibodies (bNAbs). Identification and characterization of these bNAbs and understanding their evolution dynamics are critical for obtaining useful clues for the development of an effective HIV vaccine. Very recently, we published a study in which we identified 12 HIV-1 subtype C-infected individuals from India whose plasma showed potent and broad cross-clade neutralization (BCN) ability (1). In the present study, we report our findings on the evolution of host bNAb response over a period of 4 years in a subset of these individuals. Three of the five individuals (NAB033, NAB059, and NAB065) demonstrated a significant increase (p < 0.05) in potency. Interestingly, two of the three samples also showed a significant increase in CD4 binding site-specific antibody response, maintained stable CD4+ T cell counts (>350 cells/mm3) and continued to remain ART-naïve for more than 10 years after initial diagnosis, implying a strong clinical correlation with the development and evolution of broadly neutralizing antibody response against HIV-1.
Hepatic ethoxyresorufin‐O‐deethylase induction in the common kingfisher from an electronic waste recycling site

The health effects of exposure to electronic waste (e‐waste)‐derived pollutants are an important issue. The authors explored the association between the hepatic levels of e‐waste–derived halogenated contaminants (including polychlorinated biphenyls [PCBs], polybrominated diphenyl ethers [PBDEs], and polybrominated biphenyls [PBBs]) and hepatic ethoxyresorufin‐O‐deethylase (EROD) activity of the common kingfisher (Alcedo atthis) from an e‐waste site and 2 reference sites in South China. The summed concentrations of PCBs, PBDEs, and PBBs ranged from 620 ng/g to 15 000 ng/g, 25 ng/g to 900 ng/g, and 14 ng/g to 49 ng/g wet weight, respectively, in the kingfishers from the e‐waste site, and these values were significantly greater (2–3 orders of magnitude) than those obtained at the 2 reference sites. Correspondingly, significant hepatic EROD induction was observed in the kingfishers from the e‐waste site compared with the reference sites. The EROD activity was significantly correlated to the levels of most of the PCB and PBDE congeners examined as well as PBB 153, suggesting that EROD induction may be evoked by these e‐waste–derived pollutants. Environ Toxicol Chem 2016;35:1594–1599. © 2015 SETAC
Raising quality whilst reducing cost in health care: A retrospective cohort study

OBJECTIVE The objective of this study was to investigate the relationship between cost and quality within the health care sector and to establish which factors could influence this relationship. The aim was to investigate the dynamics of the relationship, in order to improve the quality whilst reducing the cost. DESIGN This is a retrospective cohort study, analysing quality, safety, and financial data from a 5-year period. SETTING A publicly funded tertiary hospital. PARTICIPANTS The dependent variable was cost saved, and the independent variables were patient safety, patient satisfaction, and clinical efficiency. MAIN OUTCOME MEASURES Financial savings and quality domains. RESULTS A statistically significant relationship between the variables was found. Multivariate analysis derived the equation Y = βX1 + c, where Y is the cost saved, β is the beta coefficient, X1 is the clinical efficiency, and c is a constant. R2 = 0.874 (coefficient of determination), which suggested that the cost saved by the unit varied due to clinical efficiency. Clinical efficiency accounted for 87.4% of the variation in the cost saved by the unit. CONCLUSIONS The results indicated that, after the trade-off value, an improvement in the quality would result in reduced costs for the unit. Clinical efficiency of the services was found to be the key factor determining this relationship. Therefore, strategies to increase clinical efficiency, and thus overall quality, above the trade-off level could result in significant financial savings. Patient safety and patient experience were positively correlated with clinical efficiency.
Temporal and latitudinal trends of p,p′‐DDE in eggs and carcasses of North American birds from 1980 to 2005

The use of 1,1,1‐trichloro‐2,2‐bis(p‐chlorophenyl) ethane (DDT) in agriculture in the United States and Canada was prohibited in the early 1970s; however, it continued to be used restrictively in Mexico until 2000. Forty years later, 1,1‐dichloro‐2,2‐bis(p‐chlorophenyl) ethylene (p,p′‐DDE), continues to be detected in eggs and bird carcasses in North America. The use of DDE has been associated with reproductive failure of several avian species, primarily through eggshell thinning. To assess the temporal and latitudinal distribution of p,p′‐DDE in North America, the authors examined DDE concentrations reported in bird tissues in the scientific literature published between 1980 and 2009. Overall, the majority of supported models suggested that DDE concentrations in birds were greater in the upper mid‐latitudes (38°–48°) than in other parts of North America. However, spatial trends of DDE seemed to be influenced by regions with large amounts of data, such as the Great Lakes area. Concentrations of p,p′‐DDE in eggs averaged 2.5 μg/g, 3.2 μg/g, and 29.5 μg/g wet weight in 1980 and decreased to 1.64 μg/g, 0.87 μg/g, and 1.01 μg/g wet weight by the mid‐2000s for the central, eastern, and western North America regions, respectively. The results indicate that, over time, all DDE residues observed in birds have decreased significantly in North America. Environ Toxicol Chem 2016;35:1340–1348. © 2016 SETAC
Surgical Site Infection in a Tertiary Neonatal Surgery Centre

Abstract Introduction Surgical site infection (SSI) is a key performance indicator to assess the quality of surgical care. Incidence and risk factors for SSI in neonatal surgery are lacking in the literature. Aim To define the incidence of SSI and possible risk factors in a tertiary neonatal surgery centre. Materials and Methods This is a prospective cohort study of all the neonates who underwent abdominal and thoracic surgery between March 2012 and October 2016. The variables analyzed were gender, gestational age, birth weight, age at surgery, preoperative stay in neonatal intensive care unit, type of surgery, length of stay, and microorganisms isolated from the wounds. Statistical analysis was done with chi-square, Student's t- or Mann–Whitney U-tests. A logistic regression model was used to evaluate determinants of risk for SSI; variables were analyzed both with univariate and multivariate models. For the length of hospital stay, a logistic regression model was performed with independent variables. Results A total of 244 neonates underwent 319 surgical procedures. The overall incidence of SSIs was 43/319 (13.5%). The only statistical differences between neonates with and without SSI were preoperative stay (<4 days vs. ≥4 days, p < 0.01) and length of hospital stay (<30 days vs. ≥30 days, p < 0.01). A pre-operative stay longer than 4 days was associated with almost three times increased risk of SSI (odds ratio [OR] 2.96, 95% confidence interval [CI] 1.05–8.34, p = 0.0407). Gastrointestinal procedures were associated with more than ten times the risk of SSI compared with other procedures (OR 10.17, 95% CI 3.82–27.10, p < 0.0001). Gastroschisis closure and necrotizing enterocolitis (NEC) laparotomies had the highest incidence SSI (54% and 62%, respectively). The risk of longer length of hospital stay after SSI was more than three times higher (OR = 3.36, 95%CI 1.63–6.94, p = 0.001). Conclusion This is the first article benchmarking the incidence of SSI in neonatal surgery in the United Kingdom. A preoperative stay ≥4 days and gastrointestinal procedures were independent risk factors for SSI. More research is needed to develop strategies to reduce SSI in selected neonatal procedures.
Applying Existing Named Entity Taggers at BARR IBEREVAL 2017 Task

We present our experiments applying, off-the-shelf, two existing Named Entity Recognition (NER) taggers for the Biomedical Abbreviation Recognition and Resolution (BARR) task at IberEval 2017. The first system is a Perceptron tagger based on sparse, shallow features whereas the second is a bidirectional Long-Short Term Memory neural network with a sequential conditional random layer above it (LSTM-CRF) and initialized with ngram word embeddings. Due to time constraints, we only managed to submit a run from the Perceptron tagger, although in this paper we will also report results with the LSTM-CRF tagger evaluated on the development data. Results show that both Perceptron and LSTMCRF perform reasonably well for SHORT abbreviations whereas the Perceptron model fails to generalize properly for the LONG entity class.
User satisfaction with a real-time automated feedback system for general practitioners: a quantitative and qualitative study.

OBJECTIVE The GRIF automated feedback system produces real-time comments on the appropriateness of diagnostic tests ordered by general practitioners (GPs) based on recommendations from accepted national and regional practice guidelines. We investigated the experiences of GPs with this system and, more specifically, with the recommendations produced by the system as well as their views on using this system in daily practice. SETTING We tested the GRIF system in an experiment in a laboratory setting and in a daily practice trial. STUDY PARTICIPANTS General practitioners. INTERVENTION In the laboratory experiment, GPs used the GRIF system to assess the appropriateness of 30 request forms. Each of the GPs was confronted with requests they had submitted to the diagnostic unit of the hospital in the past. In the field trial, the GRIF system was applied during patient consultations for 1 year. MAIN OUTCOME MEASURES We measured GPs' satisfaction with the system using a questionnaire, and also conducted group discussions (in the laboratory experiment) and in-depth interviews (in the field trial) to elicit GPs' opinions of and experiences with the system. In addition, we explored GPs' reasons for not accepting the comments offered by the GRIF system. RESULTS The results show that the GPs in the laboratory experiment had more positive attitudes towards the system compared with participants in the field trial. All discussion groups and most of the GPs in the field trial regarded receiving the immediate feedback during the test ordering process as an important advantage. The most frequently mentioned reason to reject the recommendation was disagreement with the content and/or the recommendations in the practice guidelines. CONCLUSION Apart from securing agreement on guideline content, a prerequisite for using GRIF in daily practice on a large scale is that more attention is paid to promotion of the guidelines and their adoption, and stimulation of a positive attitude towards the practice guidelines among the users.
NGC 7419: a young open cluster with a number of very young intermediate mass pre-MS stars

We present a photometric and spectroscopic study of the young open cluster NGC 7419, which is known to host a large number of classical Be stars for reasons not well understood. Based on CCD photometric observations of 327 stars in UBV passbands, we estimated the cluster parameters as, reddening (E(B V)) = 1.65±0.15 mag and distance = 2900 ± 400 pc. The turn-off age of the cluster was estimated as 25± 5 Myr using isochrone fits. UBV data of the stars were combined with the JHK data from 2MASS and were used to create the near infrared (NIR) (J H) vs (H K) colourcolour diagram. A large fraction of stars (42%) was found to have NIR excess and their location in the diagram was used to identify them as intermediate mass pre-MS stars. The isochrone fits to pre-MS stars in the optical colour-magnitude diagram showed that the turn-on age of the cluster is 0.3 –3 Myr. This indicates that there has been a recent episode of star formation in the vicinity of the cluster.
Impacts of Deepwater Horizon crude oil exposure on adult mahi‐mahi (Coryphaena hippurus) swim performance

The temporal and geographic attributes of the Deepwater Horizon incident in 2010 likely exposed pelagic game fish species, such as mahi‐mahi, to crude oil. Although much of the research assessing the effects of the spill has focused on early life stages of fish, studies examining whole‐animal physiological responses of adult marine fish species are lacking. Using swim chamber respirometry, the present study demonstrates that acute exposure to a sublethal concentration of the water accommodated fraction of Deepwater Horizon crude oil results in significant swim performance impacts on young adult mahi‐mahi, representing the first report of acute sublethal toxicity on adult pelagic fish in the Gulf of Mexico following the spill. At an exposure concentration of 8.4 ± 0.6 µg L−1 sum of 50 selected polycyclic aromatic hydrocarbons (PAHs; mean of geometric means ± standard error of the mean), significant decreases in the critical and optimal swimming speeds of 14% and 10%, respectively (p < 0.05), were observed. In addition, a 20% reduction in the maximum metabolic rate and a 29% reduction in aerobic scope resulted from exposure to this level of ΣPAHs. Using environmentally relevant crude oil exposure concentrations and a commercially and ecologically valuable Gulf of Mexico fish species, the present results provide insight into the effects of the Deepwater Horizon oil spill on adult pelagic fish. Environ Toxicol Chem 2016;35:2613–2622. © 2016 SETAC