Miracle-dz/UniFAR-FTUs huggingface dataset:
Work–family enrichment and satisfaction: the mediating role of self-efficacy and work–life balance

Although the direct effects of work–family enrichment on satisfaction are well-documented, previous theoretical predictions and empirical findings of the relationship have been inconsistent. Drawing on social cognitive theory, the current research examined how work–family enrichment contributes to job and family satisfaction by exploring the mediating mechanisms of self-efficacy and work–life balance. This study also empirically validated a new self-efficacy measure using the work–life interface nomological network. A heterogeneous sample of Australian employees (N = 234) from four different organisations responded to two waves of data collection separated by a 12-month interval. Using structural equation modelling, the results of the statistical analysis provided preliminary support for the hypothesised chain mediation model and the newly developed five-item self-efficacy to regulate work and life scale. Specifically, work-to-family enrichment and family-to-work enrichment were positively related to self-efficacy, which in turn had a positive effect on work–life balance. Similarly, work–life balance had a positive impact on job and family satisfaction. Evidence of these relationships over time was demonstrated, thereby emphasising the importance of person–cognitive resources (e.g. self-efficacy) in influencing life outcomes. Validation of the self-efficacy scale also demonstrated robust psychometric properties and criterion validity. Implications of these results were subsequently discussed.
Role of C/EBPβ Transcription Factor in Adult Hippocampal Neurogenesis

Background The dentate gyrus of the hippocampus is one of the regions in which neurogenesis takes place in the adult brain. We have previously demonstrated that CCAAT/enhancer binding protein β (C/EBPβ) is expressed in the granular layer of the dentate gyrus of the adult mouse hippocampus. Taking into account the important role of C/EBPβ in the consolidation of long term memory, the fact that newborn neurons in the hippocampus contribute to learning and memory processes, and the role of this transcription factor, previously demonstrated by our group, in regulating neuronal differentiation, we speculated that this transcription factor could regulate stem/progenitor cells in this region of the brain. Methodology/Principal Findings Here, we show, using C/EBPβ knockout mice, that C/EBPβ expression is observed in the subset of newborn cells that proliferate in the hippocampus of the adult brain. Mice lacking C/EBPβ present reduced survival of newborn cells in the hippocampus, a decrease in the number of these cells that differentiate into neurons and a diminished number of cells that are proliferating in the subgranular zone of the dentate gyrus. These results were further confirmed in vitro. Neurosphere cultures from adult mice deficient in C/EBPβ present less proliferation and neuronal differentiation than neurospheres derived from wild type mice. Conclusions/Significance In summary, using in vivo and in vitro strategies, we have identified C/EBPβ as a key player in the proliferation and survival of the new neurons produced in the adult mouse hippocampus. Our results support a novel role of C/EBPβ in the processes of adult hippocampal neurogenesis, providing new insights into the mechanisms that control neurogenesis in this region of the brain.
The mRNP remodeling mediated by UPF1 promotes rapid degradation of replication-dependent histone mRNA

Histone biogenesis is tightly controlled at multiple steps to maintain the balance between the amounts of DNA and histone protein during the cell cycle. In particular, translation and degradation of replication-dependent histone mRNAs are coordinately regulated. However, the underlying molecular mechanisms remain elusive. Here, we investigate remodeling of stem-loop binding protein (SLBP)-containing histone mRNPs occurring during the switch from the actively translating mode to the degradation mode. The interaction between a CBP80/20-dependent translation initiation factor (CTIF) and SLBP, which is important for efficient histone mRNA translation, is disrupted upon the inhibition of DNA replication or at the end of S phase. This disruption is mediated by competition between CTIF and UPF1 for SLBP binding. Further characterizations reveal hyperphosphorylation of UPF1 by activated ATR and DNA-dependent protein kinase upon the inhibition of DNA replication interacts with SLBP more strongly, promoting the release of CTIF and eIF3 from SLBP-containing histone mRNP. In addition, hyperphosphorylated UPF1 recruits PNRC2 and SMG5, triggering decapping followed by 5′-to-3′ degradation of histone mRNAs. The collective observations suggest that both inhibition of translation and recruitment of mRNA degradation machinery during histone mRNA degradation are tightly coupled and coordinately regulated by UPF1 phosphorylation.
The Growth Aftermath of Natural Disasters

This paper provides a description of the macroeconomic aftermath of natural disasters. It traces the yearly response of gross domestic product growth - both aggregated and disaggregated into its agricultural and non-agricultural components - to four types of natural disasters - droughts, floods, earthquakes, and storms. The paper uses a methodological approach based on pooling the experiences of various countries over time. It consists of vector auto-regressions in the presence of endogenous variables and exogenous shocks (VARX), applied to a panel of cross-country and time-series data. The analysis finds heterogeneous effects on a variety of dimensions. First, the effects of natural disasters are stronger, for better or worse, on developing than on rich countries. Second, while the impact of some natural disasters can be beneficial when they are of moderate intensity, severe disasters never have positive effects. Third, not all natural disasters are alike in terms of the growth response they induce, and, perhaps surprisingly, some can entail benefits regarding economic growth. Thus, droughts have a negative effect on both agricultural and non-agricultural growth. In contrast, floods tend to have a positive effect on economic growth in both major sectors. Earthquakes have a negative effect on agricultural growth but a positive one on non-agricultural growth. Storms tend to have a negative effect on gross domestic product growth but the effect is short-lived and small. Future research should concentrate on exploring the mechanisms behind these heterogeneous impacts.
On the Estimation of Coherence

Low-rank matrix approximations are often used to help scale standard machine learning algorithms to large-scale problems. Recently, matrix coherence has been used to characterize the ability to extract global information from a subset of matrix entries in the context of these low-rank approximations and other sampling-based algorithms, e.g., matrix com- pletion, robust PCA. Since coherence is defined in terms of the singular vectors of a matrix and is expensive to compute, the practical significance of these results largely hinges on the following question: Can we efficiently and accurately estimate the coherence of a matrix? In this paper we address this question. We propose a novel algorithm for estimating coherence from a small number of columns, formally analyze its behavior, and derive a new coherence-based matrix approximation bound based on this analysis. We then present extensive experimental results on synthetic and real datasets that corroborate our worst-case theoretical analysis, yet provide strong support for the use of our proposed algorithm whenever low-rank approximation is being considered. Our algorithm efficiently and accurately estimates matrix coherence across a wide range of datasets, and these coherence estimates are excellent predictors of the effectiveness of sampling-based matrix approximation on a case-by-case basis.
Taking the Victim Out of Sexual Assault: The Effect of Self-Compassion on Sexual Assault Survivors

Self-compassion is defined as the ability to treat oneself kindly following perceived failures and/or painful events; this construct is characterized by three components: self-kindness, common humanity and mindfulness (Neff, 2003). Although some people may naturally be more self-compassionate than others, previous self-compassion manipulations have shown that selfcompassion is a mindset that can be taught. Several short-term self-compassion inductions have been published (Adams & Leary, 2007; Breines & Chen, 2012; Leary, Tate, Adams, Allen, & Hancock, 2007) showing that such inductions lead to more positive emotional and behavioral outcomes. The purpose of this research study was to determine whether a short self-compassion induction would impact people’s responses to an imagined sexual assault scenario. Female undergraduates (N = 141) were randomly assigned to a self-compassion condition or a control. All participants imagined a vivid sexual assault scenario and rated how they anticipated they would feel following the scenario (i., e emotion, less identity, fault, state self-compassion, formal and informal disclosure, and future behavioral intentions). Women who received the selfcompassion induction experienced less negative effects following the scenario than participants in the control condition. Some of these effects (e.g., negative emotion, negative identity, formal and informal disclosure) were moderated by past sexual assault experiences showing that the self-compassion induction was more effective for women with no previous sexual assault experience. Comparing groups based on sexual assault history revealed the benefits of a short self-compassion induction may be limited to those with no previous experience. If applied to domestic violence programs, we recommend using a longer self-compassion intervention.
A Novel Evaluation of World No Tobacco Day in Latin America

Background World No Tobacco Day (WNTD), commemorated annually on May 31, aims to inform the public about tobacco harms. Because tobacco control surveillance is usually annualized, the effectiveness of WNTD remains unexplored into its 25th year. Objective To explore the potential of digital surveillance (infoveillance) to evaluate the impacts of WNTD on population awareness of and interest in cessation. Methods Health-related news stories and Internet search queries were aggregated to form a continuous and real-time data stream. We monitored daily news coverage of and Internet search queries for cessation in seven Latin American nations from 2006 to 2011. Results Cessation news coverage peaked around WNTD, typically increasing 71% (95% confidence interval [CI] 61–81), ranging from 61% in Mexico to 83% in Venezuela. Queries indicative of cessation interest peaked on WNTD, increasing 40% (95% CI 32–48), ranging from 24% in Colombia to 84% in Venezuela. A doubling in cessation news coverage was associated with approximately a 50% increase in cessation queries. To gain a practical perspective, we compared WNTD-related activity with New Year’s Day and several cigarette excise tax increases in Mexico. Cessation queries around WNTD were typically greater than New Year’s Day and approximated a 2.8% (95% CI –0.8 to 6.3) increase in cigarette excise taxes. Conclusions This novel evaluation suggests WNTD had a significant impact on popular awareness (media trends) and individual interest (query trends) in smoking cessation. Because WNTD is constantly evolving, our work is also a model for real-time surveillance and potential improvement in WNTD and similar initiatives.
Women's pelvic floor muscle strength and urinary and anal incontinence after childbirth: a cross-sectional study.

OBJECTIVE To analyse pelvic floor muscle strength (PFMS) and urinary and anal incontinence (UI and AI) in the postpartum period. METHOD Cross-sectional study carried out with women in their first seven months after child birth. Data were collected through interviews, perineometry (Peritron™), and the International Consultation on Incontinence Questionnaire-Short Form (ICIQ-SF). RESULTS 128 women participated in the study. The PFMS mean was 33.1 (SD=16.0) cmH2O and the prevalence of UI and AI was 7.8% and 5.5%, respectively. In the multiple analyses, the variables associated with PFMS were type of birth and cohabitation with a partner. Newborn's weight, previous pregnancy, UI during pregnancy, and sexual activity showed an association with UI after child birth. Only AI prior to pregnancy was associated with AI after childbirth. CONCLUSION Vaginal birth predisposes to the reduction of PFMS, and caesarean section had a protective effect to its reduction. The occurrence of UI during pregnancy is a predictor of UI after childbirth, and women with previous pregnancies and newborns with higher weights are more likely to have UI after childbirth.AI prior to pregnancy is the only risk factor for its occurrence after childbirth. Associations between PFMS and cohabitation with a partner, and between UI and sexual activity do not make possible to conclude that these variables are directly associated. OBJETIVO Analisar a força dos músculos do assoalho pélvico e a incontinência urinária e anal no período pós-parto. MÉTODO Estudo transversal realizado com mulheres nos primeiros 7 meses após o parto. Os dados foram coletados por meio de entrevista, da perineometria (Peritron™) e do International Consultation on Incontinence Questionnaire-Short Form (ICIQ-SF). RESULTADOS Participaram do estudo 128 mulheres. A média da força dos músculos do assoalho pélvico foi 33,1 (d.p.=16,0) cmH2O e a prevalência de incontinência urinária e incontinência anal foi de 7,8% e 5,5%, respectivamente. Na análise múltipla, as variáveis associadas à força dos músculos do assoalho pélvico foram tipo de parto atual e coabitação com o parceiro. Peso do recém-nascido, gestação anterior, incontinência urinária na gestação e atividade sexual mostraram associação. Apenas a incontinência anal prévia à gestação associou-se à incontinência anal após o parto. CONCLUSÃO O parto vaginal predispõe à redução da força dos músculos do assoalho pélvico, e a cesariana exerce função protetora à sua redução. A ocorrência de incontinência urinária na gestação é preditora da incontinência urinária após o parto, e as mulheres com gestação anterior e recém-nascido de maior peso têm maior propensão em apresentar incontinência urinária após o parto. Incontinência anal prévia à gestação é o único fator de risco para sua ocorrência após o parto. As associações entre força dos músculos do assoalho pélvico e coabitação com o parceiro e entre incontinência urinária e atividade sexual não permitem concluir que essas variáveis estejam diretamente relacionadas.
Optimizing cost and performance trade-offs for MapReduce job processing in the cloud

Cloud computing offers a new, attractive option to customers for provisioning a suitable size Hadoop cluster, consuming resources as a service, executing the MapReduce workload, and paying for the time these resources were used. One of the open questions in such environments is the choice and the amount of resources that a user should lease from the service provider. In this work1, we offer a framework for evaluating and selecting the right underlying platform (e.g., small, medium, or large EC2 instances) and achieving the desirable Service Level Objectives (SLOs). A user can define a set of different SLOs: i) achieving a given completion time for a set of MapReduce jobs while minimizing the cost (budget), or ii) for a given budget select the type and the number of instances that optimize the MapReduce workload performance (i.e., the completion time of the jobs). We demonstrate that the application performance of a customer workload may vary significantly on different platforms. This makes a selection of the best cost/performance platform for a given workload being a challenging problem. Our evaluation study and experiments with Amazon EC2 platform reveal that for different workload mixes the optimized platform choice may result in 37-70% cost savings for achieving the same performance objectives when using different (but seemingly equivalent) choices. The results of our simulation study are validated through experiments with Hadoop clusters deployed on different Amazon EC2 instances.
Systematic Review and Empirical Comparison of Contemporaneous EQ-5D and SF-6D Group Mean Scores

Background. Group mean estimates and their underlying distributions are the focus of assessment for cost and outcome variables in economic evaluation. Research focusing on the comparability of alternative preference-based measures of health-related quality of life has typically focused on analysis of individual-level data within specific clinical specialties or community-based samples. Purpose. To explore the relationship between group mean scores for the EQ-5D and SF-6D across the utility scoring range. Methods. Studies were identified via a systematic search of 13 online electronic databases, a review of reference lists of included papers, and hand searches of key journals. Studies were included if they reported contemporaneous mean EQ-5D and SF-6D health state scores. All (sub)group comparisons of group mean EQ-5D and SF-6D scores identifiable from text, tables, or figures were extracted from identified studies. A total of 921 group mean comparisons were extracted from 56 studies. The nature of the relationship between the paired scores was examined using ranked scatter graphs and analysis of agreement. Results. Systematic differences in group mean estimates were observed at both ends of the utility scale. At the lower (upper) end of the scale, the SF-6D (EQ-5D) provides higher mean utility estimates. Conclusions. These findings show that group mean EQ-5D and SF-6D scores are not directly comparable. This raises serious concerns about the cross-study comparability of economic evaluations that differ in the choice of preference-based measures, although the review focuses on 2 of the available instruments only. Further work is needed to address the practical implications of noninterchangeable utility estimates for cost-per-QALY estimates and decision making.
The Safety and Efficacy of an Enzyme Combination in Managing Knee Osteoarthritis Pain in Adults: A Randomized, Double-Blind, Placebo-Controlled Trial

This randomized, double-blind, placebo-controlled, and comparator-controlled trial evaluated the safety and efficacy of an enzyme combination, as Wobenzym, in adults with moderate-to-severe osteoarthritis (OA) of the knee. Adults (n = 150) received Wobenzym, diclofenac (a nonsteroidal anti-inflammatory drug, NSAID), or placebo for 12 weeks. Improvement in pain scores (Lequesne Functional Index) did not differ between subjects treated with Wobenzym or diclofenac, and both treatment groups improved compared to placebo (P < 0.05). Reduction in total WOMAC scores (secondary outcome measure) did not differ between Wobenzym and diclofenac, although only diclofenac emerged as different from placebo (P < 0.05). The median number of rescue medication (paracetamol) tablets consumed was less in the Wobenzym group compared to placebo (P < 0.05), while there was no difference between diclofenac and placebo. Adverse events were similar in frequency in Wobenzym and placebo groups (7.2% and 9.1% of subjects, resp.) and higher in diclofenac group (15.6%). Wobenzym is comparable to the NSAID diclofenac in relieving pain and increasing function in adults with moderate-to-severe painful knee OA and reduces reliance on analgesic medication. Wobenzym is associated with fewer adverse events and, therefore, may be appropriate for long-term use.
Incentives for delay-constrained data query in mobile opportunistic social networks

In this paper, we propose effective schemes to stimulate cooperation between selfish nodes for data query and feedback in mobile opportunistic social networks. A query issuer generates a query and requests reply within a given delay budget. When a data provider receives the query for the first time from an intermediate node, the former replies it, and authorizes the latter as the owner of the reply. Multiple copies of a query can be created and replied by different data providers. When a node that owns a reply meets the query issuer that generates the query, it requests the query issuer to pay credits. The query issuer pays credits and provides a feedback of the reply to the data provider. When a node that carries a feedback meets the data provider, the data provider pays credits to the node in order to adjust its claimed expertise. Queries, replies and feedbacks can be traded between mobile nodes. We propose an effective mechanism to define rewards for queries, replies and feedbacks. We formulate the bargain process as a two-person cooperative game, whose solution is found by using the Nash Theorem. Extensive simulations have been carried out based on real-world traces to evaluate the proposed schemes.
International and indigenous diagnoses of mental disorder among Vietnamese living in Vietnam and Australia.

BACKGROUND Whether the prevalence rates of common mental disorders can be compared across countries depends on the cultural validity of the diagnostic measures used. AIMS To investigate the prevalence of Western and indigenously defined mental disorders among Vietnamese living in Vietnam and in Australia, comparing the data with an Australian-born sample. METHOD Comparative analysis of three multistage population surveys, including samples drawn from a community living in the Mekong Delta region of Vietnam (n=3039), Vietnamese immigrants residing in New South Wales, Australia (n=1161), and an Australian-born population (n=7961). Western-defined mental disorders were assessed by the Composite International Diagnostic Interview (CIDI) 2.0 and included DSM-IV anxiety, mood and substance use disorders as well as the ICD-10 category of neurasthenia. The Vietnamese surveys also applied the indigenously based Phan Vietnamese Psychiatric Scale (PVPS). Functional impairment and service use were assessed. RESULTS The prevalence of CIDI mental disorders for Mekong Delta Vietnamese was 1.8% compared with 6.1% for Australian Vietnamese and 16.7% for Australians. Inclusion of PVPS mental disorders increased the prevalence rates to 8.8% for Mekong Delta Vietnamese and 11.7% for Australian Vietnamese. Concordance was moderate to good between the CIDI and the PVPS for Australian Vietnamese (area under the curve (AUC)=0.77) but low for Mekong Vietnamese (AUC=0.59). PVPS- and CIDI-defined mental disorders were associated with similar levels of functional impairment. CONCLUSIONS Cultural factors in the expression of mental distress may influence the prevalence rates of mental disorders reported across countries. The findings have implications for assessing mental health needs at an international level.
Modeling in an Architectural Variability Description Language

In order to handle the large amount of variability in product families, automated product derivation support is desirable. To make automated product derivation possible one important ingredient is that the solution domain should be formalized. This should allow the formal description of the variability and the formal description of the choices. Such a formalization should be presented to the application engineer in a way that gives insight in the functioning of the system. To give insight in the structure and functioning of a software system at a high-level of abstraction, an architectural description is often used. Lately, socalled ADL’s (Architectural Description Languages) have been introduced for allowing clear architectural descriptions with well-defined semantics. It is the contribution of this paper to provide an ADL extension called AVDL (Architectural Variability Description Language), which allows formalizing variability at the architectural level. Relevant aspects of AVDL are described in this paper, and the promising results of applying AVDL to two industrial based examples are presented.