Miracle-dz/UniFAR-FTUs huggingface dataset:
Best Practices of Mobile Health in Clinical Care: The Development and Evaluation of a Competency-Based Provider Training Program

This article describes the development and evaluation of a training program for behavioral health providers on the integration of mobile health applications (health apps) in clinical care. The purpose was to train military and Department of Veterans Affairs (VA) providers in the use and current research of various behavioral health apps. The training focused on 5 core competencies: gaining knowledge on the evidence base for using mobile apps in behavioral health practice, effective integration of mobile technologies into traditional treatment settings, security and privacy issues involved with digital data, ethical issues, and cultural considerations. During a 3-year span (October 2014–September 2017), the training program delivered 20 one-day workshops at 15 military or VA locations, reaching 760 Department of Defense and VA clinicians (psychologists, social workers, physicians, and nurses) on best practices for health apps in clinical care. Prior to the training, less than half of the providers who attended the workshop (41.1%) reported that they were using health apps during treatment. Just following the training, 93.7% of the trainees indicated their intent to use health apps during patient care. At the 3-month posttraining interval, provider-reported use of health apps in treatment was 90.8%. Results demonstrated the impact of a mobile apps provider training program to deliver a relevant, feasible, and impactful approach to educating providers regarding mobile health best practices. Data collected also provided valuable insight into military provider technology use over a 3-year period.
Intergenerational exchange: undergraduate researchers’ learning and listening enhanced through older adults’ entertainment preferences

ABSTRACT The purpose of this qualitative study was to provide an intergenerational exchange as undergraduate students taking an introductory Psychology of Aging course, interviewed and watched films with older adult participants (N = 13) residing in an assisted living community. The undergraduate researchers (N = 10) conducted and transcribed interviews, wrote about their perceptions of interviews and film viewing with older adults, and their instructor interviewed assisted living staff (N = 2) creating an assessment of participants, researchers, and staff. Researchers listened and learned from older adult’s words, thereby improving researchers’ understanding that older adults preferred in-person discussions over film viewing. Researchers learned from older adults’ words, as they began to understand that sexual content in today’s films may reduce entertainment viewing for youth and older adults. Older adults described television remotes and phones with frustration and researchers felt angst for their frustration. Findings suggested understanding and meaning for participants and researchers in this service learning intergenerational exchange generated through undergraduate research.
Nonquadratic stabilization of Takagi-Sugeno models: a piecewise quadratic approach

This paper deals with the stabilization of Takagi-Sugeno models (T-S) using state feedback controllers. New sufficient stability conditions are given for both continuous and discrete T-S models. The stability conditions, formulated in term of bilinear matrix inequalities (BMIs), are based on a piecewise quadratic Lyapunov function and the use of the so-called S-procedure. A method of linearisation, applied on the obtained BMIs conditions, is presented.
Computing reaction rates in bio-molecular systems using discrete macro-states

Computing reaction rates in biomolecular systems is a common goal of molecular dynamics simulations. The reactions considered often involve conformational changes in the molecule, either changes in the structure of a protein or the relative position of two molecules, for example when modeling the binding of a protein and ligand. Here we will consider the general problem of computing the rate of transfer from a subset A of the conformational space Omega to a subset B of Omega. It is assumed that A and B are associated with minimum energy basins and are long-lived states. Rates can be obtained using many different methods. We review some of the most popular approaches. We organize the different approaches roughly in chronological order and under four main categories: reactive flux, transition path sampling, conformation dynamics. The fourth class of methods, to which we do not give any specific name, in some sense attempts to combine features from transition path sampling and conformation dynamics. They include non-equilibrium umbrella sampling (Warmflash et al. [2007], Dickson et al. [2009b]), and weighted ensemble dynamics (Huber and Kim [1996]).
A new approach to performance evaluation of generalized selection diversity receivers in wireless channels

Motivated by potential applications to wideband cellular DS-CDMA and millimeter-wave communications, the study of the generalized selection combining (GSC) receiver that adaptively combines a subset of M "strongest" paths out of L available paths has intensified over the past few years. The study of the GSC(M, L) receiver is also important from a theoretical standpoint because this model encapsulates both the classical selection combining receiver and the maximal-ratio combining receiver as limiting cases. Despite its importance, published results on GSC(M, L) receiver performance in a generalized fading channel are still very limited, mainly due to the mathematical difficulty encountered while computing the first-order statistics of a linear sum of ordered random variables. This paper provides a partial solution to the problem on hand by deriving relatively simple-to-evaluate expressions for the moment generating function (MGF) of GSC output SNR in a variety of fading environments given that the individual branch SNRs are independent and identically distributed. Moreover, our generic single integral expression for the MGF of GSC output SNR reduces to a closed-form formula if the branch amplitudes follow either Rayleigh or Nakagami-m (positive integer fading index) distribution. An easily programmable recursive solution of the MGF in Nakagami-m channels is also provided. Our expressions hold for any M and L values, and thus facilitate a comprehensive analysis of GSC systems including the average symbol error probability (ASEP) analysis of a broad class of binary and M-ary modulations, average combined SNR and the outage rate of error probability analysis.
Mother Tongue Interference in the Writing of English as a Second Language (ESL) Malay Learners

The objective of this study is to identify the errors in writing committed by Malay ESL learners which can be attributed to mother tongue interference. Twenty pre-degree quantity surveyor students from Universiti Teknologi MARA Perak campus participated in the study. They were instructed to write between 200- to 300-word essays on a given topic in English and in Malay. Their compositions were analyzed using the algorithm for conducting error analysis (EA) proposed by James (1998) which are practiced by current EA practitioners. Since the main focus of the study is mother tongue interference, only errors related to L1 interference were addressed. The paper presents and discusses the descriptive analysis of the results in relation to three major types of interference which are ‘transfer of rules’, ‘redundancy reduction’ and ‘overgeneralization’.
Content Based Video Retrieval Using Spatiotemporal Salient Objects

In this paper, we propose a spatiotemporal salient objects-based approach for video retrieval. The spatiotemporal salient object is defined as the region sequence which is spatial salient and temporal continuous at the same time. As attention analysis is an effective mechanism for salient information selection, it provides a practical approach to narrow the semantic gap. Most existing methods extract salient region from static image, while little work has been done on the temporal consistency of salient region in dynamic image sequences, which is very important for content based video retrieval. We propose a fusion method for motion and spatial saliency integration to detect spatiotemporal salient objects, based on both attention analysis and interest point trajectory tracking. A novel description of trajectories’ spatial context is also presented in this paper. Experiment results demonstrate the advantages of the proposed method in video content analysis and retrieval.
Realigning Thunder and Lightning: Temporal Adaptation to Spatiotemporally Distant Events

The brain is able to realign asynchronous signals that approximately coincide in both space and time. Given that many experience-based links between visual and auditory stimuli are established in the absence of spatiotemporal proximity, we investigated whether or not temporal realignment arises in these conditions. Participants received a 3-min exposure to visual and auditory stimuli that were separated by 706 ms and appeared either from the same (Experiment 1) or from different spatial positions (Experiment 2). A simultaneity judgment task (SJ) was administered right afterwards. Temporal realignment between vision and audition was observed, in both Experiment 1 and 2, when comparing the participants’ SJs after this exposure phase with those obtained after a baseline exposure to audiovisual synchrony. However, this effect was present only when the visual stimuli preceded the auditory stimuli during the exposure to asynchrony. A similar pattern of results (temporal realignment after exposure to visual-leading asynchrony but not after exposure to auditory-leading asynchrony) was obtained using temporal order judgments (TOJs) instead of SJs (Experiment 3). Taken together, these results suggest that temporal recalibration still occurs for visual and auditory stimuli that fall clearly outside the so-called temporal window for multisensory integration and appear from different spatial positions. This temporal realignment may be modulated by long-term experience with the kind of asynchrony (vision-leading) that we most frequently encounter in the outside world (e.g., while perceiving distant events).
Phylogenetic Insights into the Functional Relationship between Primate Lentiviral Reverse Transcriptase and Accessory Proteins Vpx/Vpr

The efficiency of reverse transcription to synthesize viral DNA in infected cells greatly influences replication kinetics of retroviruses. However, viral replication in non-dividing cells such as resting T cells and terminally differentiated macrophages is potently and kinetically restricted by a host antiviral factor designated SAMHD1 (sterile alpha motif and HD-domain containing protein 1). SAMHD1 reduces cellular deoxynucleoside triphosphate (dNTP) pools and affects viral reverse transcription step. Human immunodeficiency virus type 2 (HIV-2) and some simian immunodeficiency viruses (SIVs) have Vpx or Vpr to efficiently degrade SAMHD1. Interestingly, the reverse transcriptase (RT) derived from HIV-1 that encodes no anti-SAMHD1 proteins has been previously demonstrated to uniquely exhibit a high enzymatic activity. It is thus not irrational to assume that some viruses may have acquired or lost the specific RT property to better adapt themselves to the low dNTP environments confronted in non-dividing cells. This adaptation process may probably be correlated with the SAMHD1-antagonizing ability by viruses. In this report, we asked whether such adaptive events can be inferable from Vpx/Vpr and RT phylogenetic trees overlaid with SAMHD1-degrading capacity of Vpx/Vpr and with kinetic characteristics of RT. Resultant two trees showed substantially similar clustering patterns, and therefore suggested that the properties of RT and Vpx/Vpr can be linked. In other words, HIV/SIVs may possess their own RT proteins to adequately react to various dNTP circumstances in target cells.
Internalized homophobia and depression in lesbian women: The protective role of pride

Abstract This study sought to examine the association between internalized homophobia and depressive symptoms in lesbian women, and establish whether such a relationship was mediated by collective self-esteem, self-esteem, and self-disclosure. Participants were 225 self-identified lesbian women in the community. Structural equation modeling was used to demonstrate that an underlying construct, labeled pride, reflected participants’ levels of self-esteem, collective self-esteem, and self-disclosure. Internalized homophobia was moderately and negatively predictive of pride, and pride was strongly and negatively predictive of depression. Results highlight the potentially protective role of pride in the prevention of depression among lesbian women.
SAbDab: the structural antibody database

Structural antibody database (SAbDab; http://opig.stats.ox.ac.uk/webapps/sabdab) is an online resource containing all the publicly available antibody structures annotated and presented in a consistent fashion. The data are annotated with several properties including experimental information, gene details, correct heavy and light chain pairings, antigen details and, where available, antibody–antigen binding affinity. The user can select structures, according to these attributes as well as structural properties such as complementarity determining region loop conformation and variable domain orientation. Individual structures, datasets and the complete database can be downloaded.
Outcome of Vancomycin Treatment in Patients with Methicillin-Susceptible Staphylococcus aureus Bacteremia

ABSTRACT Limited data on the clinical outcome of vancomycin treatment compared with that of beta-lactam treatment in patients with methicillin-susceptible Staphylococcus aureus bacteremia (MSSA-B) are available. We used different and complementary approaches: (i) a retrospective cohort study using a propensity score to adjust for confounding by treatment assignment and (ii) a matched case-control study. Of all patients with S. aureus bacteremia (SAB) in two university-affiliated hospitals over a 7-year period, 294 patients with MSSA-B were enrolled in the cohort study. The cases for the case-control study were defined as patients who received vancomycin treatment for MSSA-B; the controls, who were patients that received beta-lactam treatment for MSSA-B, were selected at a 1:2 (case:control) ratio according to the objective matching scoring system and the propensity score system. In the cohort study, SAB-related mortality in patients with vancomycin treatment (37%, 10/27) was significantly higher than that in those with beta-lactam treatment (18%, 47/267) (P = 0.02). In addition, multivariate analysis revealed that vancomycin treatment was associated with SAB-related mortality when independent predictors for SAB-related mortality and propensity score were considered (adjusted odds ratio of 3.3, 95% confidence interval of 1.2 to 9.5). In the case-control study using the objective matching scoring system and the propensity score system, SAB-related mortality in case patients was 37% (10/27) and in control patients 11% (6/54) (P < 0.01). Our data suggest that vancomycin is inferior to beta-lactam in the treatment of MSSA-B.
Acute inflammatory and anabolic systemic responses to peak and constant-work-rate exercise bout in hospitalized patients with COPD

Study objectives: To explore the acute systemic inflammatory and anabolic effects of cycling in hospital admitted patients with chronic obstructive pulmonary disease (COPD) and in patients with clinically stable disease. Design: Cross-sectional comparative study. Setting: University Hospital Gasthuisberg, a tertiary care setting. Patients: 16 patients with clinically stable COPD (no acute exacerbation in the past 12 weeks; median age: 73 years (IQR: 60 to 75); median forced expiratory volume in the first second (FEV1): 45% predicted (IQR: 33 to 58)) and 14 patients who were admitted to a hospital due an acute exacerbation of COPD (median age: 65 years (IQR: 59 to 74); median FEV1 to on day 8 of hospital stay: 41% predicted (IQR: 33 to 54)). Interventions: None. Measurements and results: Circulating levels of C reactive protein, interleukin 6, interleukin 8 and insulin-like growth factor I were determined before, at the end and 2 and 30 minutes after a symptom-limited peak cycling test and before, at the end and 2 and 30 minutes after a symptom-limited constant-work-rate cycling test at 70% of the peak load. Non-significant changes in the circulating markers of inflammation and anabolism were found during or up to 30 minutes after ceasing the peak or constant-work-rate cycling exercise tests. The systemic responses of the hospitalized patients with COPD did not differ from those with clinically stable disease. Conclusions: High-intensity cycling exercises did not increase the circulating levels of inflammatory markers in patients with chronic obstructive pulmonary disease, irrespective of their clinical stability.
Do You Look to the Future or Focus on Today? The Impact of Life Experience on Intertemporal Decisions

In this research, we investigate the impact of signiWcant life experiences on intertemporal decisions among young adults. A series of experiments focus speciWcally on the impact of experiencing the death of a close other by cancer. We show that such an experience, which bears information about time, is associated with making decisions that favor the long-term future over short-term interests (Studies 1 and 2). Underlying this eVect appears to be increased salience and concreteness regarding one’s future life course, shifting focus away from the present toward the long run (Studies 3 and 4). Finally, we explore the shift caused by a cancer death of a public Wgure and examine its stability over time (Study 5). Implications for research on intertemporal decision making and the impact of life events on perceptions and preferences are discussed.
Pengaruh Pijat Oksitosin terhadap Produksi ASI pada Ibu Nifas

ASI tidak keluar adalah kondisi tidak diproduksinya ASI atau sedikitnya produksi ASI.Hal ini disebabkan pengaruh hormon oksitosin yang kurang bekerja sebab kurangnya rangsangan isapan bayi yang mengaktifkan kerja hormon oksitosin.Pijat oksitosin merupakan salah satu solusi untuk mengatasi ketidaklancaran produksi ASI. Tujuan penelitian ini untuk mengidentifikasi perbedaan produksi ASI pada ibu nifas yang diberi perlakuan pijat oksitosin dan tanpa perlakuan di BPM Lia Maria Kecamatan Sukarame Bandar Lampung tahun 2017. Metode penelitian yang digunakan dalam penelitian ini adalah eksperimental dengan desain rancangan posttest dengan kelompok kontrol. Populasi pada penelitian ini adalah ibu nifas 3 jam postpartum di BPM Lia Maria berjumlah 80 orang. Sampel dalam penelitian ini diambil melalui cara purposive sampling. Sampel berjumlah 32 orang yang terdiri dari 16 orang sebagai responden yang di intervensi dan 16 orang sebagai variabel kontrol.Instrumen penelitian yang digunakan berupa lembar observasi untuk mengamati produksi ASI pada hari ke 6 dan timbangan. Hasil Uji statistik menggunakan chi-square (x2) diperoleh p-value= 0,037 (p-value ≤0,05) yang berarti ada pengaruh signifikan antara pijat oksitosin terhadap produksi ASI pada ibu post partum di BPM Lia Maria Sukarame Bandar Lampung Tahun 2017. Diharapkan hasil penelitian ini dapat meningkatkan kualitas pelayanan bagi tenaga kesehatan terutama bidan sebagai pelaksana sehingga dapat meningkatkan pengetahuan ibu akan pijat oksitosin dan dapat memotivasi ibu dan keluarga untuk melakukan pijat oksitosin dan memberikan bimbingan serta penyuluhan kepada ibu nifas tentang manfaat pijat oksitosin.
Hair Microelement Profile as a Prognostic Tool in Parkinson’s Disease

Changes in the homeostasis of metals and microelements have been demonstrated in Parkinson’s disease, whose etiology includes both a genetic and environmental basis. We studied the difference of microelements in the hair of Parkinson’s disease subjects (n = 46) compared with healthy controls (n = 24). Hair was chosen as a representative matrix to measure microelements, since it is a vehicle of substance excretion from the human body and it allows for long-term evaluation of metal exposure. An inductively coupled plasma mass spectrometry (ICP-MS) analysis of hair collected from 24 Parkinson’s patients compared with their healthy relatives used as controls shows a significant decrease in Ca (U = 166, p = 0.012),), Mg (U = 187, p = 0.037), and Sr (U = 183, p = 0.030). Cd and Ca/Mg were decreased, and Cu was increased, in patients with respect to their healthy related controls at the limit of significance (p = 0.0501). Principal Component Analysis (PCA) of these microelements in hair shows a clustering into two groups according to gender, disease severity according to the Hoehn–Yahr scale, and pharmacological therapy. This pilot study represents a starting point for future investigations where a larger group of subjects will be involved to define other microelements useful when screening for early biomarkers of Parkinson’s disease.
Reinforcement Learning with Bounded Information Loss

Policy search is a successful approach to reinforcement learning. However, policy improvements often result in the loss of information. Hence, it has been marred by premature convergence and implausible solutions. As first suggested in the context of covariant or natural policy gradients, many of these problems may be addressed by constraining the information loss. In this paper, we continue this path of reasoning and suggest two reinforcement learning methods, i.e., a model‐based and a model free algorithm that bound the loss in relative entropy while maximizing their return. The resulting methods differ significantly from previous policy gradient approaches and yields an exact update step. It works well on typical reinforcement learning benchmark problems as well as novel evaluations in robotics. We also show a Bayesian bound motivation of this new approach [8].
A Novel Pathway for Sesquiterpene Biosynthesis from Z,Z-Farnesyl Pyrophosphate in the Wild Tomato Solanum habrochaites[W]

In the wild tomato Solanum habrochaites, the Sst2 locus on chromosome 8 is responsible for the biosynthesis of several class II sesquiterpene olefins by glandular trichomes. Analysis of a trichome-specific EST collection from S. habrochaites revealed two candidate genes for the synthesis of Sst2-associated sesquiterpenes. zFPS encodes a protein with homology to Z-isoprenyl pyrophosphate synthases and SBS (for Santalene and Bergamotene Synthase) encodes a terpene synthase with homology to kaurene synthases. Both genes were found to cosegregate with the Sst2 locus. Recombinant zFPS protein catalyzed the synthesis of Z,Z-FPP from isopentenylpyrophosphate (IPP) and dimethylallylpyrophosphate (DMAPP), while coincubation of zFPS and SBS with the same substrates yielded a mixture of olefins identical to the Sst2-associated sesquiterpenes, including (+)-α-santalene, (+)-endo-β-bergamotene, and (−)-endo-α-bergamotene. In addition, headspace analysis of tobacco (Nicotiana sylvestris) plants expressing zFPS and SBS in glandular trichomes afforded the same mix of sesquiterpenes. Each of these proteins contains a putative plastid targeting sequence that mediates transport of a fused green fluorescent protein to the chloroplasts, suggesting that the biosynthesis of these sesquiterpenes uses IPP and DMAPP from the plastidic DXP pathway. These results provide novel insights into sesquiterpene biosynthesis and have general implications concerning sesquiterpene engineering in plants.