Miracle-dz/UniFAR-FTUs huggingface dataset:
Assessment of Cerebrovascular Reactivity during Resting State Breathing and Its Correlation with Cognitive Function in Hypertension

Background: Hypertension is associated with cognitive deficits, particularly executive function, and decreased cerebral microvascular responsiveness to CO2 (CO2 vasoreactivity). The relation between CO2 vasoreactivity and executive function is not known. Protocols to assess CO2 vasoreactivity are cumbersome and require inhaling a CO2-enriched gas. We explored the ability to measure CO2 vasoreactivity using end-tidal CO2 fluctuations during normal breathing and the association of this measure with cognitive function in hypertension. Methods: Executive function (Trail-Making Test parts A/B), memory, attention and blood flow velocity (BFV) in the middle cerebral artery using transcranial Doppler were measured in hypertensive subjects who were tapered off their treatment for 3 weeks. BFV was measured while sitting and normally breathing for 5 min, followed by breathing 5% CO2 gas and hyperventilation for 2 min each. We calculated CO2 vasoreactivity as the rate of BFV change from hypoventilation to hyperventilation, and as a model-derived measure using the normal breathing data. The latter was derived using nonlinear principal dynamic modes (PDM), which modelled the dynamic effect of fluctuations in end-tidal CO2 and blood pressure upon BFV during normal room-air respiration. Multiple regression analyses were used to correlate cerebral hemodynamics with cognitive measures. Results: Data were collected from 41 individuals with hypertension (mean age 71 years, 24% African Americans, 61% women, off antihypertensive therapy). Lower CO2 vasoreactivity was associated with a worse executive function test score using both calculation methods: p value using the hyper/hypoventilation data was 0.04 and from the PDM analysis was 0.009. PDM calculations showed a stronger correlation with executive function (0.41 vs. 0.21 using the hyper/hypoventilation data). There were no associations with memory or attention measures. There was a weak but statistically significant correlation between the two calculation methods of CO2 vasoreactivity (R2 = 14%, p = 0.02). Conclusion: This study suggests that the decrease in CO2 vasoreactivity in hypertension is associated with lower executive function. This may offer new insight into the vascular underpinning of cognitive decline in hypertension. We demonstrate that calculating CO2 vasoreactivity is possible during normal breathing. If replicated in future studies, this may offer a more convenient clinical way to assess CO2 vasoreactivity in hypertension and cognitive disorders.
Compact Ka band filter in 0.13 µm CMOS using broadside coupled coplanar stripline

A Ka band bandpass filter in 0.13 μm CMOS is presented. Good out-of-band rejection and a good shape factor are facilitated by the use of broadside coupled coplanar stripline (BCCPS). The filter consists of a BCCPS section, coplanar striplines (CPS), and MIM capacitors. We derive the characteristic impedance and effective dielectric constant of the BCCPS in CMOS and apply it to the design of the bandpass filter. The realized filter has a measured 3 dB bandwidth from 25.5 GHz to 31.6 GHz (21%). The measured insertion loss is 6.9 dB and the size is 0.6 × 0.3 mm2 excluding pads. The filter rejection below 18 GHz and above 41 GHz is better than 35 dB.
Adaptive informative path planning in metric spaces

In contrast to classic geometric motion planning, informative path planning (IPP) seeks a path for a robot to sense the world and gain information. In adaptive IPP, the robot chooses the next sensing location conditioned on all information acquired so far, and the robot’s goal is to minimize the travel cost required for identifying a true hypothesis. Adaptive IPP is NP-hard, because the robot must trade-off information gain and travel cost optimally. In this paper we present Recursive Adaptive Identification (RAId), a new polynomial-time approximation algorithm for adaptive IPP. We prove a polylogarithmic approximation bound when the robot travels in a metric space. Furthermore, our experiments suggest that RAId is practical and provides good approximate solutions for two distinct robot planning tasks. Although RAId is designed primarily for noiseless observations, a simple extension allows it to handle some tasks with noisy observations.
BMMRU BRAND MANAGEMENT AND MARKETING RESEARCH UNIT

The importance and impact of reputation is well documented in the literature. Yet scant empirical research has been conducted into the way different stakeholder groups define and assess reputation. This paper examines the way that different stakeholder groups define a brand’s reputation and identifies the criteria they use to evaluate a financial services brand’s reputation. The findings provide confirmation of many of the themes discerned in definitions of reputation proposed in the literature. However, in contrast to the literature, the research revealed that different stakeholder groups do not necessarily use different criteria to evaluate reputation, but rather emphasise different criteria.
Regional differences in technology : theory and empirics

The aim of this paper is, on the one hand, to give a review of several streams in the litera-ture which differ with respect to the extent they assume knowledge to spread over regions. On the other hand, this paper shows the extent to which these theories are supported empirically. The regional neoclassical growth model focuses on the immediate diffusion of technological knowledge. Alternative theories like cumulative causation and imperfect diffusion theories focus on the issue that technology gaps between regions will persist over time. Cumulative causation assumes that there exists no diffusion of knowledge, while imperfect diffusion theories assume that diffusion will take place, though slowly. These theoretical insights lead to several testable hypotheses on the presence and the development over time of regional technology gaps. This paper attempts to use a new set of data on R&D in the European Union to explore this field. Evidence from regional R&D statistics will be used to highlight differences in technological activity between the regions within the leading European economies. Also the factors that are proposedly related to the relative technological activity of a region are analysed, in addition to the long term implications of technology gaps.
Is neurofeedback an efficacious treatment for ADHD? A randomised controlled clinical trial.

BACKGROUND For children with attention deficit/hyperactivity disorder (ADHD), a reduction of inattention, impulsivity and hyperactivity by neurofeedback (NF) has been reported in several studies. But so far, unspecific training effects have not been adequately controlled for and/or studies do not provide sufficient statistical power. To overcome these methodological shortcomings we evaluated the clinical efficacy of neurofeedback in children with ADHD in a multisite randomised controlled study using a computerised attention skills training as a control condition. METHODS 102 children with ADHD, aged 8 to 12 years, participated in the study. Children performed either 36 sessions of NF training or a computerised attention skills training within two blocks of about four weeks each (randomised group assignment). The combined NF treatment consisted of one block of theta/beta training and one block of slow cortical potential (SCP) training. Pre-training, intermediate and post-training assessment encompassed several behaviour rating scales (e.g., the German ADHD rating scale, FBB-HKS) completed by parents and teachers. Evaluation ('placebo') scales were applied to control for parental expectations and satisfaction with the treatment. RESULTS For parent and teacher ratings, improvements in the NF group were superior to those of the control group. For the parent-rated FBB-HKS total score (primary outcome measure), the effect size was . 60. Comparable effects were obtained for the two NF protocols (theta/beta training, SCP training). Parental attitude towards the treatment did not differ between NF and control group. CONCLUSIONS Superiority of the combined NF training indicates clinical efficacy of NF in children with ADHD. Future studies should further address the specificity of effects and how to optimise the benefit of NF as treatment module for ADHD.
PERFORMANCE OF RANDOM LATTICE ALGORITHMS

We have implemented different algorithms for generating Poissonian and vectorizable random lattices. The random lattices fulfil the Voronoi/Delaunay construction. We measure the performance of our algorithms for the two types of random lattices and find that the average computation time is proportional to the number of points on the lattice.
The Plasma Mitochondrial DNA Is an Independent Predictor for Post-Traumatic Systemic Inflammatory Response Syndrome

Background and Purpose Mitochondrial DNA (mtDNA), a newly identified damage-associated molecular pattern, has been observed in trauma patients, however, little is known concerning the relationship between plasma mtDNA levels and concrete post-traumatic complications, particularly systemic inflammatory response syndrome (SIRS). The aim of this study is to determine whether plasma mtDNA levels are associated with injury severity and cloud predict post-traumatic SIRS in patients with acute traumatic injury. Patients and Methods Eighty-six consecutive patients with acute traumatic injury were prospectively enrolled in this study. The plasma mtDNA concentration was measured by a real-time, quantitative PCR assay for the human ND2 gene. The study population’s clinical and laboratory data were analyzed. Results The median plasma mtDNA was higher in trauma patients than in healthy controls (865.196 (251.042-2565.40)pg/ml vs 64.2147 (43.9049-80.6371)pg/ml, P<0.001) and was independently correlated with the ISS score (r=0.287, P<0.001). The plasma mtDNA concentration was also significantly higher in patients who developed post-traumatic SIRS than in patients who did not (1774.03 (564.870-10901.3)pg/ml vs 500.496 (145.415-1285.60)pg/ml, P<0.001). Multiple logistic regression analysis revealed that the plasma mtDNA was an independent predictors for post-traumatic SIRS (OR, 1.183 (95%CI, 1.015-1.379), P=0.032). Further ROC analysis demonstrated that a high plasma mtDNA level predicted post-traumatic SIRS with a sensitivity of 67% and a specificity of 76%, with a cut-off value of 1.3185 µg/ml being established, and the area under the ROC curves (AUC) was 0.725 (95% CI 0.613-0.837). Conclusions Plasma mtDNA was an independent indictor with moderate discriminative power to predict the risk of post-traumatic SIRS.
Dynamic Metabolic Changes during the First 3 Months after 90Y-Ibritumomab Tiuxetan Radioimmunotherapy

Objective. To elucidate the time course of tumor metabolism during the first 3 months after 90Y-ibritumomab tiuxetan radioimmunotherapy (RIT) in patients with refractory malignant lymphoma. Materials and Methods. Seven patients with recurrent follicular lymphoma underwent FDG-PET imaging before and after 1-, 4-, and 12-week RIT with 90Y-ibritumomab tiuxetan. Tumor metabolic activity on FDG-PET scans was assessed as the maximum standard uptake value (SUVmax). Results. Decrease in metabolism was detected 1 week after RIT. In the most decreased lesion, SUVmax decreased to 20% of the baseline value during the first week. Most lesions continued to decrease for up to 4 weeks. Some lesions showed increased metabolism from 4 to 12 weeks, while the level of FDG accumulations at 12 weeks was still lower than the baseline. Conclusions. Tumor response to RIT could be observed as early as 1 week after the administration of RIT. After tumor activity decreases, the metabolism may increase at least between 4 and 12 weeks. It suggests that the metabolic changes should be carefully evaluated during this period.
Solid tumor size on high-resolution computed tomography and maximum standardized uptake on positron emission tomography for new clinical T descriptors with T1 lung adenocarcinoma.

BACKGROUND To better describe clinical T descriptors using solid tumor size (the maximum dimension of the solid component of the tumor) on high-resolution computed tomography (HRCT) and maximum standardized uptake value (SUVmax) on F-18-fluorodeoxyglucose positron emission tomography/CT (FDG-PET/CT). PATIENTS AND METHODS We examined 610 consecutive patients with clinical stage IA lung adenocarcinoma who underwent complete resection. Recurrence-free survival (RFS) was assessed on the basis of whole tumor size (maximum dimension of the tumor), solid tumor size, or a combination of solid tumor size and SUVmax. RESULTS RFS based on whole tumor size was not significantly different between patients with tumors measuring ≤2 cm and 2-3 cm (P = 0.089), whereas RFS based on solid tumor size was significantly different (P < 0.0001). We divided patients into four groups on the basis of solid tumor size and SUVmax: group 1: solid tumor size ≤2 cm, SUVmax ≤1.8; group 2: solid tumor size ≤2 cm, SUVmax >1.8; group 3: solid tumor size 2-3 cm, SUVmax ≤3.6; and group 4: solid tumor size 2-3 cm, SUVmax >3.6. Groups 2 and 3 were combined because they showed similar RFS each other. RFS was significantly different among these groups: group 1 versus groups 2 + 3, P < 0.0001; groups 2 + 3 versus group 4, P = 0.019. CONCLUSIONS Both solid tumor size on HRCT and SUVmax on FDG-PET/CT reflect prognosis well in patients with clinical stage IA lung adenocarcinoma and may support new clinical T descriptors.
Phylogenetic-based nomenclatural proposals for Ophiocordycipitaceae (Hypocreales) with new combinations in Tolypocladium

Ophiocordycipitaceae is a diverse family comprising ecologically, economically, medicinally, and culturally important fungi. The family was recognized due to the polyphyly of the genus Cordyceps and the broad diversity of the mostly arthropod-pathogenic lineages of Hypocreales. The other two cordyceps-like families, Cordycipitaceae and Clavicipitaceae, will be revised taxonomically elsewhere. Historically, many species were placed in Cordyceps, but other genera have been described in this family as well, including several based on anamorphic features. Currently there are 24 generic names in use across both asexual and sexual life stages for species of Ophiocordycipitaceae. To reflect changes in Art. 59 in the International Code of Nomenclature for algae, fungi, and plants (ICN), we propose to protect and to suppress names within Ophiocordycipitaceae, and to present taxonomic revisions in the genus Tolypocladium, based on rigorous and extensively sampled molecular phylogenetic analyses. When approaching this task, we considered the principles of priority, monophyly, minimizing taxonomic revisions, and the practical utility of these fungi within the wider biological research community.
Blind separation of discrete sources

A polynomial criterion is proposed to perform blind source separation, extending previous works to MIMO systems. The criterion is proved to be asymptotically MAP-equivalent in presence of PSK sources. An efficient minimization algorithm dedicated to polynomial criteria is then developed, improving on the fixed-step stochastic gradient previously utilized in this framework.
Fragile Watermarking for Image Authentication Using the Characteristic of SVD

Digital image authentication has become a hot topic in the last few years. In this paper, a pixel-based fragile watermarking method is presented for image tamper identification and localization. By analyzing the left and right singular matrices of SVD, it is found that the matrix product between the first column of the left singular matrix and the transposition of the first column in the right singular matrix is closely related to the image texture features. Based on this characteristic, a binary watermark consisting of image texture information is generated and inserted into the least significant bit (LSB) of the original host image. To improve the security of the presented algorithm, the Arnold transform is applied twice in the watermark embedding process. Experimental results indicate that the proposed watermarking algorithm has high security and perceptual invisibility. Moreover, it can detect and locate the tampered region effectively for various malicious attacks.
Erythropoietin attenuates the sequels of ischaemic spinal cord injury with enhanced recruitment of CD34+ cells in mice

Erythropoietin has been shown to promote tissue regeneration after ischaemic injury in various organs. Here, we investigated whether Erythropoietin could ameliorate ischaemic spinal cord injury in the mouse and sought an underlying mechanism. Spinal cord ischaemia was developed by cross‐clamping the descending thoracic aorta for 7 or 9 min. in mice. Erythropoietin (5000 IU/kg) or saline was administrated 30 min. before aortic cross‐clamping. Neurological function was assessed using the paralysis score for 7 days after the operation. Spinal cords were histologically evaluated 2 and 7 days after the operation. Immunohistochemistry was used to detect CD34+ cells and the expression of brain‐derived neurotrophic factor and vascular endothelial growth factor. Each mouse exhibited either mildly impaired function or complete paralysis at day 2. Erythropoietin‐treated mice with complete paralysis demonstrated significant improvement of neurological function between day 2 and 7, compared to saline‐treated mice with complete paralysis. Motor neurons in erythropoietin‐treated mice were more preserved at day 7 than those in saline‐treated mice with complete paralysis. CD34+ cells in the lumbar spinal cord of erythropoietin‐treated mice were more abundant at day 2 than those of saline‐treated mice. Brain‐derived neurotrophic factor and vascular endothelial growth factor were markedly expressed in lumbar spinal cords in erythropoietin‐treated mice at day 7. Erythropoietin demonstrated neuroprotective effects in the ischaemic spinal cord, improving neurological function and attenuating motor neuron loss. These effects may have been mediated by recruited CD34+ cells, and enhanced expression of brain‐derived neurotrophic factor and vascular endothelial growth factor.
On the Cyclical Behavior of Employment, Unemployment and Labor Force Participation

In this paper I evaluate to what extent a real business cycle (RBC) model that incorporates search and leisure decisions can simultaneously account for the observed behavior of employment, unemployment and out-of-the-labor-force. This contrasts with the previous RBC literature, which analyzed employment or hours fluctuations by either lumping together unemployment and out-of-the-labor-force into a single non-employment state or assuming a fixed labor force participation. Once the three employment states are explicitly introduced I find that the RBC model generates highly counterfactual labor market dynamics.
Blood Glucose Control in the Intensive Care Unit: Benefits and Risks

Abnormal blood glucose levels are common during critical illness and are associated with outcomes that correspond to a J‐shaped curve, the lowest risk associated with normoglycemia. Three proof‐of‐concept randomized‐controlled‐trials performed in the surgical, medical, and pediatric intensive care units of the Leuven University Hospital in Belgium demonstrated that maintaining strict age‐adjusted normal fasting levels of glycemia (80–110 mg/dl in adults, 70–100 mg/dl in children, 50–80 mg/dl in infants) with intensive insulin therapy reduced morbidity and mortality as compared with tolerating stress hyperglycemia as a potentially beneficial response. Recently, concern has risen about the safety of this intervention, as a multicenter adult study reported an, as yet unexplained, increased mortality with targeting normoglycemia as compared with an intermediate blood glucose level of around 140 mg/dl. This apparent contradiction may be explained by several methodological differences among studies, comprising, among others, different glucose target ranges in the control groups, different feeding policies, and variable accuracy of tools used for glucose measurement and insulin infusion. Hence, efficacy and safety of intensive insulin therapy may be affected by patient‐related and ICU setting‐related variables. Therefore, no single optimal blood glucose target range for ICU patients can be advocated. It appears safe not to embark on targeting “age‐normal” levels in intensive care units (ICUs) that are not equipped to accurately and frequently measure blood glucose, and have not acquired extensive experience with intravenous insulin administration using a customized guideline. A simple fallback position could be to control blood glucose levels as close to normal as possible without evoking unacceptable blood glucose fluctuations, hypoglycemia, and hypokalemia.
Overexpression of Rab1B and MMP9 predicts poor survival and good response to chemotherapy in patients with colorectal cancer

Rab1B has recently been reported to be involved in human cancer, but the role of Rab1B in colorectal cancer (CRC) remains unclear. In this study, we investigated the expression of Rab1B and MMP9 in CRC by qRT-PCR, immunoblot and immunohistochemistry and analyzed the clinical significance. The results show that Rab1B and MMP9 are increased at both mRNA and protein levels in CRC cell lines and tissues, as measured by qRT-PCR and immunoblotting. The high protein expression of Rab1B and MMP9 in 179 CRC tissues is associated with deep tumor invasion, lymph-node metastasis and advanced TNM stage. Survival analysis indicates that patients with overexpression of Rab1B or MMP9 have significantly worse overall survival and progression-free survival, but better response to chemotherapy than those with low expression of proteins, and that Rab1B is an independent prognostic factor for CRC patients. Furthermore, when Rab1B and MMP9 are combined into a new risk model, it has a remarkably better prediction of prognosis than each protein alone. In conclusion, Rab1B and MMP9 are potential prognostic biomarkers and their combination significantly improves predictive power for survival and chemotherapy response in CRC patients.