Miracle-dz/UniFAR-FTUs huggingface dataset:
Revisiting Host Preference in the Mycobacterium tuberculosis Complex: Experimental Infection Shows M. tuberculosis H37Rv to Be Avirulent in Cattle

Experiments in the late 19th century sought to define the host specificity of the causative agents of tuberculosis in mammals. Mycobacterium tuberculosis, the human tubercle bacillus, was independently shown by Smith, Koch, and von Behring to be avirulent in cattle. This finding was erroneously used by Koch to argue the converse, namely that Mycobacterium bovis, the agent of bovine tuberculosis, was avirulent for man, a view that was subsequently discredited. However, reports in the literature of M. tuberculosis isolation from cattle with tuberculoid lesions suggests that the virulence of M. tuberculosis for cattle needs to be readdressed. We used an experimental bovine infection model to test the virulence of well-characterized strains of M. tuberculosis and M. bovis in cattle, choosing the genome-sequenced strains M. tuberculosis H37Rv and M. bovis 2122/97. Cattle were infected with approximately 106 CFU of M. tuberculosis H37Rv or M. bovis 2122/97, and sacrificed 17 weeks post-infection. IFN-γ and tuberculin skin tests indicated that both M. bovis 2122 and M. tuberculosis H37Rv were equally infective and triggered strong cell-mediated immune responses, albeit with some indication of differential antigen-specific responses. Postmortem examination revealed that while M. bovis 2122/97–infected animals all showed clear pathology indicative of bovine tuberculosis, the M. tuberculosis–infected animals showed no pathology. Culturing of infected tissues revealed that M. tuberculosis was able to persist in the majority of animals, albeit at relatively low bacillary loads. In revisiting the early work on host preference across the M. tuberculosis complex, we have shown M. tuberculosis H37Rv is avirulent for cattle, and propose that the immune status of the animal, or genotype of the infecting bacillus, may have significant bearing on the virulence of a strain for cattle. This work will serve as a baseline for future studies into the genetic basis of host preference, and in particular the molecular basis of virulence in M. bovis.
Shared leadership and group interaction styles in problem-solving virtual teams

Despite their prevailing growth, little systematic evidence exists regarding the effectiveness of computer-mediated "virtual" teams (VTs), especially in relation to their traditional counterpart, face-to-face teams (FtFTs). A partial least squares (PLS) analysis revealed that FtFTs were more likely to demonstrate higher levels of shared leadership and a constructive interaction style than were VTs. In turn, shared leadership and a constructive interaction style were shown to positively predict cohesion, whereas a defensive interaction style was shown to negatively predict cohesion. Shared leadership was also positively associated with a constructive interaction style and negatively associated with a defensive interaction style. Finally, task performance was shown to be a function of group cohesion.
Phrase-based extraction of user opinions in mobile app reviews

Mobile app reviews often contain useful user opinions like bug reports or suggestions. However, looking for those opinions manually in thousands of reviews is ineffective and time-consuming. In this paper, we propose PUMA, an automated, phrase-based approach to extract user opinions in app reviews. Our approach includes a technique to extract phrases in reviews using part-of-speech (PoS) templates; a technique to cluster phrases having similar meanings (each cluster is considered as a major user opinion); and a technique to monitor phrase clusters with negative sentiments for their outbreaks over time. We used PUMA to study two popular apps and found that it can reveal severe problems of those apps reported in their user reviews.
Helping older workers cope with continuous quality improvement

When organizations implement continuous quality improvement (CQI) programs, managers and employees are faced with massive change, often requiring a renegotiation of the psychological contract between employer and employee. This paper discusses generational differences in reactions to major change initiatives as well as change management issues in public and nonprofit organizations. Its specific focus is an organizational unit in the nonprofit sector whose CQI program, which required more employee involvement, was met with varied reactions among older veterans of its small workforce. Observations of the unit and its employees are used to develop a typology of reactions to major change among long‐time, older workers. Strategies are provided to managers who must develop methods to deal with adverse reactions to major organizational changes such as CQI. The typology may be useful to management development specialists who are attempting to transform organizations with significant age diversity.
Quaternary ammonium compounds as structural probes of single batrachotoxin-activated Na+ channels

Quaternary ammonium (QA) blockers are well-known structural probes for studying the permeation pathway of voltage-gated K+ channels. In this study we have examined the effects of a series of n-alkyl- trimethylammonium compounds (Cn-QA) on batrachotoxin (BTX)-activated Na+ channels from skeletal muscle incorporated into planar lipid bilayers. We found that these amphipathic QA compounds (Cn-QA where n = 10-18) block single Na+ channels preferentially from the internal side with equilibrium dissociation constants (KD) in the submicromolar to micromolar range. External application of amphipathic QA compounds is far less effective, by a factor of greater than 200. The block can be described by a QA molecule binding to a single site in the Na+ channel permeation pathway. QA binding affinity is dependent on transmembrane voltage with an effective valence (delta) of approximately 0.5. QA dwell times (given as mean closed times, tau c) increase as a function of n-alkyl chain length, ranging from approximately 13 ms for C10-QA to 500 ms for C18-QA at +50 mV. The results imply that there is a large hydrophobic region within the Na+ channel pore which accepts up to 18 methylene groups of the Cn-QA cation. This hydrophobic domain may be of clinical significance since it also interacts with local anesthetics such as cocaine and mepivacaine. Finally, like BTX-activated Na+ channels in bilayers, unmodified Na+ channels in GH3 cells are also susceptible to QA block. Amphipathic QA cations elicit both tonic and use-dependent inhibitions of normal Na+ currents in a manner similar to that of local anesthetic cocaine. We conclude that amphipathic QA compounds are valuable structural probes to study the permeation pathway of both normal and BTX-activated Na+ channels.
Freud and sociobiology

Darwin, Sex and Status argues that a human sociobiology that mistakes evolutionary theory for theories of psychology and culture is wrong, as are psychologies that could never have evolved or social sciences that posit impossible psychologies. Status develops theories of human self-awareness, cognition, and cultural capacity that are compatible with evolutionary theory. Recurring themes include: the importance of sexual selection in human evolution; our species' preoccupation with self-esteem and relative standing; the individual as an active strategist, regularly revising culturally provided information; and awareness as an impressionmanagement device. Culture is a somewhat structured information pool that itself evolves, often in ways that reduce the genetic fitness of its participants.
Contribution of Endothelial Nitric Oxide to Blood Pressure in Humans

Impaired endothelial-derived NO (eNO) is invoked in the development of many pathological conditions. Systemic inhibition of NO synthesis, used to assess the importance of NO to blood pressure (BP) regulation, increases BP by ≈15 mm Hg. This approach underestimates the importance of eNO, because BP is restrained by baroreflex mechanisms and does not account for a role of neurally derived NO. To overcome these limitations, we induced complete autonomic blockade with trimethaphan in 17 normotensive healthy control subjects to eliminate baroreflex mechanisms and contribution of neurally derived NO. Under these conditions, the increase in BP reflects mostly blockade of tonic eNO. NG-Monomethyl-l-arginine (250 &mgr;g/kg per minute IV) increased mean BP by 6±3.7 mm Hg (from 77 to 82 mm Hg) in intact subjects and by 21±8.4 mm Hg (from 75 to 96 mm Hg) during autonomic blockade. We did not find a significant contribution of neurally derived NO to BP regulation after accounting for baroreflex buffering. To further validate this approach, we compared the effect of NOS inhibition during autonomic blockade in 10 normotensive individuals with that of 6 normotensive smokers known to have endothelial dysfunction but who were otherwise normal. As expected, normotensive smokers showed a significantly lower increase in systolic BP during selective eNO blockade (11±4.5 versus 30±2.3 mm Hg in normotensive individuals; P<0.005). Thus, we report a novel approach to preferentially evaluate the role of eNO on BP control in normal and disease states. Our results suggest that eNO is one of the most potent metabolic determinants of BP in humans, tonically restraining it by ≈30 mm Hg.
Community-Based Chinese Schools in Southern California: A Survey of Teachers

In this study, the author examines the results of questionnaire given to 92 teachers in community-based Chinese schools (CCSs) in Southern California. Information was sought from the teachers on their academic background and aspirations, the reasons for them to choose to teach in the CCSs, and their views on the quality of the education provided by CCSs. The teachers were also asked how they saw the CCSs developing in the future. The paper discusses the findings in detail and their implications for the future of CCSs.
Serum Uric Acid and Prehypertension Among Adults Free of Cardiovascular Diseases and Diabetes

The association between serum uric acid (SUA) and prehypertension was evaluated in a racially admixed sample of civil servants aged 35 to 74 years, enrolled (2008-2010) in the Brazilian Longitudinal Study of Health (ELSA-Brasil). Of the 15 105 patients who enrolled in the study, we analyzed 3412 after excluding those who reported previous cardiovascular diseases, diabetes, or hypertension; were heavy drinkers; or had a body mass index (BMI) ≥35 kg/m2. Among the men, logistic regression, adjusted for age, race, income, birth weight, salt intake, insulin resistance, BMI, and renal function revealed odds ratios (ORs) and 95% confidence intervals (CIs) of prehypertension from the bottom quartile (referent) to the top quartile of SUA levels as follows: 0.84 (95% CI, 0.61-1.38), 0.97 (0.71-1.34) and 1.44 (1.04-2.0; P for trend .01). Analyzing for 1-standard deviation of change in SUA, the ORs were 1.19 (1.06-1.32). This association persisted in the subgroup analysis consisting of patients who were white, overweight, with a high salt intake but with normal renal function, and without metabolic syndrome. No association was found among women. In conclusion, SUA levels were associated with prehypertension among men.
Fatherhood regimes and father involvement in France and the UK

This paper contrasts and compares the institutional framework for fatherhood and father involvement and the survey evidence relating to fathers’ contribution to childcare and domestic work in the two countries. It shows that while men's contribution to such activities appears to be increasing in both France and the UK, change is slow and father involvement does not necessarily seem to correlate directly either with patterns of female labour force participation or with the support offered by the institutional framework. The authors explore the theoretical frameworks most appropriate for explaining their findings and situate them primarily in terms of Pfau-Effinger's theorization of the gender arrangement (1998, 2002, 2004). The authors conclude that while change in father involvement is slow, the introduction of statutory and organizational work–life balance measures which alter the gender order open up opportunities for negotiated change in the division of the labour in the home.
Caspase Inhibitors Attenuate Superantigen-Induced Inflammatory Cytokines, Chemokines, and T-Cell Proliferation

ABSTRACT Proinflammatory cytokines mediate the toxic effect of superantigenic staphylococcal exotoxins (SE). A pan-caspase inhibitor suppressed SE-stimulated T-cell proliferation and the production of cytokines and chemokines by human peripheral blood mononuclear cells. These data suggest that caspase inhibitors may represent a novel therapeutic modality for treating SE-induced toxic shock.
Laparoscopic Surgery or Conservative Treatment for Appendiceal Abscess in Adults? A Randomized Controlled Trial.

OBJECTIVE We hypothesized that immediate laparoscopic surgery for appendiceal abscess would result in faster recovery than conservative treatment. BACKGROUND On the basis of the retrospective studies, conservative management of appendiceal abscess is recommended as a first line treatment, but some controversy exists. METHODS Sixty adult patients diagnosed with appendiceal abscess were randomly assigned to either laparoscopic surgery (n = 30) or conservative treatment (n = 30). Hospital stay, recurrences, additional interventions, and complications within 60 days from randomization were recorded. RESULTS There was no difference in hospital stay: 4 days (interquartile range: 3-5 days) in the laparoscopy group versus 5 days (3-8) in the conservative group, P = 0.105. Patients in the laparoscopy group had 10% risk for bowel resection and 13% risk for incomplete appendectomy. There were significantly fewer patients with unplanned readmissions in the laparoscopy group: 1 (3%) versus 8 (27%), P = 0.026. Additional interventions were required in 2 (7%) patients in the laparoscopy group (percutaneous drainage) and in 9 (30%) patients in the conservative group (surgery), P = 0.042. Recurrent abscesses and failure to respond to conservative treatment were the main reasons for additional interventions. Open surgery was required in 3 (10%) patients in the laparoscopy group and in 4 (13%) patients in the conservative group. Postoperative complications occurred in 3 patients in laparoscopic group versus 2 patients in the conservative group. The rate of uneventful recovery was 90% in the laparoscopy group versus 50% in the conservative group, P = 0.002. CONCLUSIONS Laparoscopic surgery in experienced hands is safe and feasible first-line treatment for appendiceal abscess. It is associated with fewer readmissions and fewer additional interventions than conservative treatment with comparable hospital stay.
Web-scale training for face identification

Scaling machine learning methods to very large datasets has attracted considerable attention in recent years, thanks to easy access to ubiquitous sensing and data from the web. We study face recognition and show that three distinct properties have surprising effects on the transferability of deep convolutional networks (CNN): (1) The bottleneck of the network serves as an important transfer learning regularizer, and (2) in contrast to the common wisdom, performance saturation may exist in CNN's (as the number of training samples grows); we propose a solution for alleviating this by replacing the naive random subsampling of the training set with a bootstrapping process. Moreover, (3) we find a link between the representation norm and the ability to discriminate in a target domain, which sheds lights on how such networks represent faces. Based on these discoveries, we are able to improve face recognition accuracy on the widely used LFW benchmark, both in the verification (1:1) and identification (1:N) protocols, and directly compare, for the first time, with the state of the art Commercially-Off-The-Shelf system and show a sizable leap in performance.
Art for Art's Sake? An Examination of Motives for Arts Performance Attendance

Given finite amounts of time for leisure activities and a consuming public that continues to feel time pressured, what drives attendance at arts performances? This study builds on existing arts research and its use of demographic characteristics by considering the psychological motives of theater patrons. Six potential motives of performing arts attendees are identified, and their relationship with demographic characteristics and behavioral outcomes are assessed. Data were obtained from a midwestern U.S. performing arts center; the sample was drawn from spectators at three different performances. Analysis of variance and t-test results indicate significant relationships between certain motivations and patronage variables such as years of attendance, number of performances attended, and time frame for planning to attend future events. Similarly, significant differences in motivation were found by gender, age, income, and education level, suggesting that attendance could be enhanced by tailoring motive specific messages to each of these groups.
Comparing Methods to Denote Treatment Outcome in Clinical Research and Benchmarking Mental Health Care.

UNLABELLED Approaches based on continuous indicators (the size of the pre-to-post-test change; effect size or ΔT) and on categorical indicators (Percentage Improvement and the Jacobson-Truax approach to Clinical Significance) are evaluated to determine which has the best methodological and statistical characteristics, and optimal performance, in comparing outcomes of treatment providers. Performance is compared in two datasets from providers using the Brief Symptom Inventory or the Outcome Questionnaire. Concordance of methods and their suitability to rank providers is assessed. Outcome indicators tend to converge and lead to a similar ranking of institutes within each dataset. Statistically and conceptually, continuous outcome indicators are superior to categorical outcomes as change scores have more statistical power and allow for a ranking of providers at first glance. However, the Jacobson-Truax approach can complement the change score approach as it presents outcome information in a clinically meaningful manner. Copyright © 2015 John Wiley & Sons, Ltd. KEY PRACTITIONERS MESSAGES When comparing various indicators or treatment outcome, statistical considerations designate continuous outcomes, such as the effect size of the pre-post change (effect size or ΔT) as the optimal choice. Expressing outcome in proportions of recovered, changed, unchanged or deteriorated patients has supplementary value, as it is more easily interpreted and appreciated by clinicians, managerial staff and, last but not the least, by patients. If categorical outcomes are used with small datasets, true differences in institutional performance may get obscured due to diminished power to detect differences. With sufficient data, outcome according to continuous and categorical indicators converge and lead to similar rankings of institutes' performance.
Engrailed Alters the Specificity of Synaptic Connections of Drosophila Auditory Neurons with the Giant Fiber

We show that a subset of sound-detecting Johnston's Organ neurons (JONs) in Drosophila melanogaster, which express the transcription factors Engrailed (En) and Invected (Inv), form mixed electrical and chemical synaptic inputs onto the giant fiber (GF) dendrite. These synaptic connections are detected by trans-synaptic Neurobiotin (NB) transfer and by colocalization of Bruchpilot-short puncta. We then show that misexpressing En postmitotically in a second subset of sound-responsive JONs causes them to form ectopic electrical and chemical synapses with the GF, in turn causing that postsynaptic neuron to redistribute its dendritic branches into the vicinity of these afferents. We also introduce a simple electrophysiological recording paradigm for quantifying the presynaptic and postsynaptic electrical activity at this synapse, by measuring the extracellular sound-evoked potentials (SEPs) from the antennal nerve while monitoring the likelihood of the GF firing an action potential in response to simultaneous subthreshold sound and voltage stimuli. Ectopic presynaptic expression of En strengthens the synaptic connection, consistent with there being more synaptic contacts formed. Finally, RNAi-mediated knockdown of En and Inv in postmitotic neurons reduces SEP amplitude but also reduces synaptic strength at the JON–GF synapse. Overall, these results suggest that En and Inv in JONs regulate both neuronal excitability and synaptic connectivity.
ASSESSING IDENTITIES OF UNIVERSITY STUDENTS IN JAPAN AND THE UNITED STATES

To examine the differences in adolescent identity between Japan and the United States, we studied university students in both countries (255 Japanese students and 145 American students). Participants completed a questionnaire about (1) self-concept (four identity domains) both in daily lives and in contexts seen as important by students, (2) commitment and exploration levels both for school education and best friends, and (3) contexts related to identity formation. Our analyses revealed that American students valued school achievement, committed and explored school education more than Japanese counterparts, and showed higher competence and positive feelings. In contrast, Japanese students showed higher inhibition scores, put greater emphasis on interpersonal contexts, and showed more commitment and exploration in these contexts. In addition, the differences in self-concepts were found consistently regardless of the importance of context. Our results suggested that social and cultural differences across countries have a significant effect on identity of university students.
Gender Quotas and the Press in Turkey: Public Debate in the Age of AKP Government

In 2004, an amendment to the Turkish Constitution advocating gender quotas was rejected by parliament. The press actively participated in public debates on the issue. A textual analysis of the coverage of this issue by four national newspapers shows that the press framed gender quotas as either preferential treatment or positive discrimination. Furthermore, they couched these frames within the larger ideological struggle between Islamism and secularism. Gender quotas became a platform for contestation over political, social and cultural power.