Miracle-dz/UniFAR-FTUs huggingface dataset:
Prevalence of Obesity and Overweight among Adults in Iranian Population (Yazd Province)

1Endocrinologist; Yazd Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. 2General Practitioner; Yazd Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. 3MSc in Biostatistics; Yazd Infectious Disease Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. 4PhD in Nutrition, Yazd Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. 5Endocrinologist; Yazd Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. 6General Practitioner; Yazd Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Adaptive replication in peer-to-peer systems

Peer-to-peer systems can be used to form a low-latency decentralized data delivery system. Structured peer-to-peer systems provide both low latency and excellent load balance with uniform query and data distributions. Under the more common skewed access distributions, however, individual nodes are easily overloaded, resulting in poor global performance and lost messages. This paper describes a lightweight, adaptive, and system-neutral replication protocol, called LAR, that maintains low access latencies and good load balance even under highly skewed demand. We apply LAR to Chord and show that it has lower overhead and better performance than existing replication strategies.
Colour rendering of indoor lighting with CIE illuminants and white LEDs for normal and colour deficient observers

The goal of this work was to evaluate the colour rendering of indoor lighting with CIE illuminants and white LEDs by estimating the chromatic diversity produced for normal and colour deficient observers. Reflectance spectra of a collection of scenes made of objects typically found indoors were obtained with hyperspectral imaging. Chromatic diversity was computed for 55 CIE illuminants and five LED light sources by estimating the number of different colours perceived in the scenes analysed. A considerable variation in chromatic diversity was found across illuminants, with the best producing about 50% more colours than the worst. For normal observers, the best illuminant was CIE FL3.8 which produced about 8% more colours than CIE illuminant A and D65; for colour deficient observers, the best illuminants varied with the type of deficiency. When the number of colours produced with a specific illuminant was compared against its colour rendering index (CRI) and gamut area index (GAI), weak correlations were obtained. Together, these results suggest that normal and colour deficient observers may benefit from a careful choice of the illuminant, and this choice may not necessarily be based only on the CRI or GAI.
Successful Radiofrequency Ablation in Patients With Previous Atrial Fibrillation Results in a Significant Decrease in Left Atrial Size

Background— The objective of the present study was to evaluate the relation between freedom from atrial fibrillation (AF) and left atrial (LA) size in patients who underwent circumferential pulmonary vein (PV) isolation and LA ablation. Methods and Results— One hundred five consecutive patients with symptomatic and drug-refractory paroxysmal or persistent AF were included in the present study. The mean age was 52±9.5 years (range, 27 to 75 years); 74 patients (70%) were male. Paroxysmal AF was present in 52 (49.5%) and persistent AF in 53 (50.5%) patients. Mean AF duration was 6.0±5.1 years in the paroxysmal AF group and 7.6±6.0 years in the persistent AF group. A 3D electroanatomic map of the LA including the PV ostia was constructed with a nonfluoroscopic navigation system (Carto, Biosense Webster). Left- and right-sided PVs were encircled by continuous radiofrequency ablation lines. We performed 128 ablation procedures in 105 patients, ie, 23 redo procedures. The mean long-term follow-up duration was 14.6±4.9 months (range, 6 to 24 months). Sinus rhythm was present in 45 patients (86.5%) in the paroxysmal AF group and in 41 patients (77.3%) in the persistent AF group at the latest follow-up. Six months after ablation, LA dimension in the persistent AF subjects who remained in sinus rhythm decreased from 44.0±5.8 to 40±4.5 mm (range, 31 to 51 mm). In contrast, in patients with recurrences of AF, LA dimension increased from 45±6.5 to 49±5.4 mm (range, 32 to 59 mm). In the successfully treated paroxysmal AF group, LA dimension decreased from 40.5±4.4 to 37.5±3.5 mm (P<0.01). Conclusions— In radiofrequency ablation of AF using an electroanatomic approach, there is a statistically significant relationship between medium-term procedural success and LA size: persistent sinus rhythm is associated with reduced and recurrent AF with increased LA dimensions.
Botryoid rhabdomyosarcoma of the nasopharynx

A case report of a Stage III botryoid rhabdomyosarcoma of the nasopharynx associated with a six-and-a-half-year survival is presented. Treatment consisted of surgery, radiotherapy (6,000 rads TCT) to the nasopharynx and maxillary sinuses bilaterally, and six cycles of polychemotherapy with Vincristine, Adriamycin, Cyclophosphamide and DTIC, without major loss of function or cosmetic deformity. The histology of the lesion is discussed with reference to recent classification and prognosis. The authors suggest that the histological type and prognosis of rhabdomyosarcoma of the nasopharynx in children may be better correlated in future studies.
Bmc Medical Genetics Ct60 Genotype Does Not Affect Ctla-4 Isoform Expression despite Association to T1d and Aitd in Northern Sweden

Background: Polymorphisms in and around the CTLA-4 gene have previously been associated to T1D and AITD in several populations. One such single nucleotide polymorphism (SNP), CT60, has been reported to affect the expression level ratio of the soluble (sCTLA-4) to full length CTLA-4 (flCTLA-4) isoforms. The aims of our study were to replicate the association previously published by Ueda et al. of polymorphisms in the CTLA-4 region to T1D and AITD and to determine whether the CT60 polymorphism affects the expression level ratio of sCTLA-4/flCTLA-4 in our population.
Genome-wide detection of alternative splicing in expressed sequences of human genes

We have identified 6201 alternative splice relationships in human genes, through a genome-wide analysis of expressed sequence tags (ESTs). Starting with approximately 2.1 million human mRNA and EST sequences, we mapped expressed sequences onto the draft human genome sequence and only accepted splices that obeyed the standard splice site consensus. A large fraction (47%) of these were observed multiple times, indicating that they comprise a substantial fraction of the mRNA species. The vast majority of the detected alternative forms appear to be novel, and produce highly specific, biologically meaningful control of function in both known and novel human genes, e.g. specific removal of the lysosomal targeting signal from HLA-DM beta chain, replacement of the C-terminal transmembrane domain and cytoplasmic tail in an FC receptor beta chain homolog with a different transmembrane domain and cytoplasmic tail, likely modulating its signal transduction activity. Our data indicate that a large proportion of human genes, probably 42% or more, are alternatively spliced, but that this appears to be observed mainly in certain types of molecules (e.g. cell surface receptors) and systemic functions, particularly the immune system and nervous system. These results provide a comprehensive dataset for understanding the role of alternative splicing in the human genome, accessible at http://www.bioinformatics. ucla.edu/HASDB.
More, smaller bacteria in response to ocean's warming?

Heterotrophic bacteria play a major role in organic matter cycling in the ocean. Although the high abundances and relatively fast growth rates of coastal surface bacterioplankton make them suitable sentinels of global change, past analyses have largely overlooked this functional group. Here, time series analysis of a decade of monthly observations in temperate Atlantic coastal waters revealed strong seasonal patterns in the abundance, size and biomass of the ubiquitous flow-cytometric groups of low (LNA) and high nucleic acid (HNA) content bacteria. Over this relatively short period, we also found that bacterioplankton cells were significantly smaller, a trend that is consistent with the hypothesized temperature-driven decrease in body size. Although decadal cell shrinking was observed for both groups, it was only LNA cells that were strongly coherent, with ecological theories linking temperature, abundance and individual size on both the seasonal and interannual scale. We explain this finding because, relative to their HNA counterparts, marine LNA bacteria are less diverse, dominated by members of the SAR11 clade. Temperature manipulation experiments in 2012 confirmed a direct effect of warming on bacterial size. Concurrent with rising temperatures in spring, significant decadal trends of increasing standing stocks (3% per year) accompanied by decreasing mean cell size (−1% per year) suggest a major shift in community structure, with a larger contribution of LNA bacteria to total biomass. The increasing prevalence of these typically oligotrophic taxa may severely impact marine food webs and carbon fluxes by an overall decrease in the efficiency of the biological pump.
Two types of North American droughts related to different atmospheric circulation patterns

Abstract. Proxy-based studies suggest that the southwestern USA is affected by two types of summer drought, often termed Dust Bowl-type droughts and 1950s-type droughts. The spatial drought patterns of the two types are distinct. It has been suggested that they are related to different circulation characteristics, but a lack of observation-based data has precluded further studies. In this paper, we analyze multi-annual summer droughts in North America back to 1600 in tree-ring-based drought reconstructions and in a global, monthly three-dimensional reconstruction of the atmosphere. Using cluster analysis of drought indices, we confirm the two main drought types and find a similar catalog of events as previous studies. These two main types of droughts are then analyzed with respect to 2 m temperatures (T2m), sea-level pressure (SLP), and 500 hPa geopotential height (GPH) in boreal summer. 1950s-type droughts are related to a stronger wave train over the Pacific–North American sector than Dust Bowl-type droughts, whereas the latter show the imprint of a poleward-shifted jet and establishment of a Great Plains ridge. The 500 hPa GPH patterns of the two types differ significantly not only over the contiguous United States and Canada but also over the extratropical North Atlantic and the Pacific. Dust Bowl-type droughts are associated with positive GPH anomalies, while 1950s-type droughts exhibit strong negative GPH anomalies. In comparison with 1950s-type droughts, the Dust Bowl-type droughts are characterized by higher sea-surface temperatures (SSTs) in the northern North Atlantic. Results suggest that atmospheric circulation and SST characteristics not only over the Pacific but also over the extratropical North Atlantic affect the spatial pattern of North American droughts.
Liver Transplantation for Acute Intermittent Porphyria is Complicated by a High Rate of Hepatic Artery Thrombosis

Acute intermittent porphyria (AIP) is an autosomal‐dominant condition resulting from a partial deficiency of the ubiquitously expressed enzyme porphobilinogen deaminase. Although its clinical expression is highly variable, a minority of patients suffer recurrent life‐threatening neurovisceral attacks despite optimal medical therapy. Because the liver is the major source of excess precursor production, liver transplantation (LT) represents a potentially effective treatment for severely affected patients. Using data from the UK Transplant Registry, we analyzed all transplants performed for AIP in the United Kingdom and Ireland. Between 2002 and 2010, 10 patients underwent LT for AIP. In all cases, the indication for transplantation was recurrent, biochemically proven, medically nonresponsive acute attacks of porphyria resulting in significantly impaired quality of life. Five patients had developed significant neurological morbidities such as paraplegia before transplantation. The median follow‐up time was 23.4 months, and there were 2 deaths from multiorgan failure at 98 days and 26 months. Eight recipients were alive for 3.2 to 109 months after transplantation. Complete biochemical and symptomatic resolution was observed in all patients after transplantation. However, there was a high rate of hepatic artery thrombosis (HAT; 4/10), with 1 patient requiring regrafting. The effects of previous neuronal damage such as joint contractures were not improved by transplantation. Thus, impaired quality of life in the surviving patients was usually a result of preoperative complications. Refractory AIP is an excellent indication for LT, and long‐term outcomes for carefully selected patients are good. There is, however, an increased incidence of HAT in these patients, and we recommend routine antiplatelet therapy after transplantation. Liver Transpl 18:195–200, 2012. © 2011 AASLD.
The Activation of the Sox2 RR2 Pluripotency Transcriptional Reporter in Human Breast Cancer Cell Lines is Dynamic and Labels Cells with Higher Tumorigenic Potential

The striking similarity displayed at the mechanistic level between tumorigenesis and the generation of induced pluripotent stem cells and the fact that genes and pathways relevant for embryonic development are reactivated during tumor progression highlights the link between pluripotency and cancer. Based on these observations, we tested whether it is possible to use a pluripotency-associated transcriptional reporter, whose activation is driven by the SRR2 enhancer from the Sox2 gene promoter (named S4+ reporter), to isolate cancer stem cells (CSCs) from breast cancer cell lines. The S4+ pluripotency transcriptional reporter allows the isolation of cells with enhanced tumorigenic potential and its activation was switched on and off in the cell lines studied, reflecting a plastic cellular process. Microarray analysis comparing the populations in which the reporter construct is active versus inactive showed that positive cells expressed higher mRNA levels of cytokines (IL-8, IL-6, TNF) and genes (such as ATF3, SNAI2, and KLF6) previously related with the CSC phenotype in breast cancer.
Randomized Controlled Trial of Functional Family Therapy for Offending and Antisocial behaviour in UK Youth [running head: RCT of FFT ]

Background: Youth offending and antisocial behavior (ASB) are associated with low quality mental health and relationships and usually lead to poor adult functioning; they are very costly for society. Family interventions are effective in children but there are few reliably effective and inexpensive interventions for adolescents. Functional Family Therapy (FFT) is an evidence-based intervention but seldom tested outside the US. Methods: 111 adolescents (10-17 years of age, M = 15.0, SD = 1.63) and their families were randomized to FFT + Management As Usual (MAU) (n=65) or to MAU (n=46). Assessments were made at baseline, 6, and 18 months after randomization and included interviews and questionnaires of parenting behaviors, Conduct Disorders and offending. Parent-child interaction was directly observed and police records obtained. Trial registration: ISCRTN27650478. Results: 89 (80%) were followed-up. In both groups, there were large reductions over time in all measures of offending and antisocial behavior (e.g. primary outcome p < 0.001), but no significant changes over time in parenting behavior or the parent-child relationship. However, there were no differences between intervention and control groups at 6 or 18 months on self-reported delinquency, police records of offending, symptoms or diagnoses of Conduct Disorders, parental monitoring or supervision, directly-observed child negative behavior, or parental positive or negative behavior. Against predictions, the intervention group showed lower levels of directly-observed child positive behavior at 18 months compared to controls. Conclusions: In contrast to most previous trials of FFT, FFT+MAU did not lead to greater reductions in youth ASB and offending compared to MAU alone, and did not lead to improvements in parenting or the parent-child relationship. This may be because the trial was more rigorously conducted than prior studies; equally, the possibility that MAU was effective requires further research.
Genome of a tardigrade: Horizontal gene transfer or bacterial contamination?

We have read the article “Evidence for extensive horizontal gene transfer from the draft genome of a tardigrade” (1) with interest and were astonished by the high number of genes horizontally transferred into the tardigrade genome. Still, we were surprised by the reported genome size of >200 Mbp, which is in stark contrast to a previously published size of ∼78 Mbp determined by the same group (2).
Perceptions of women of color who claim compound discrimination: Interpersonal judgments and perceived credibility

People of color who attribute rejection to racism and women who attribute rejection to sexism are perceived as troublemakers. Women of color may encounter racism and sexism simultaneously; however, it is unclear how compound discrimination claims are perceived. We examined interpersonal judgments of claimants and perceptions of the credibility of compound discrimination claims. In contrast to the double jeopardy perspective, which predicts that the consequences of multiple stigmas are cumulative, a Black woman (Study 1) was not perceived as a bigger troublemaker when she attributed rejection to compound discrimination versus either racism or sexism. Instead, racism and compound discrimination claims incurred similarly high interpersonal costs. Likewise, an Asian woman (Study 2) was not perceived as less credible when she attributed rejection to compound discrimination versus either racism or sexism. Instead, compound discrimination was the only discrimination attribution reliably judged as more credible and appropriate than baseline.
The transcription factor ATF5: role in cellular differentiation, stress responses, and cancer

Activating transcription factor 5 (ATF5) is a cellular prosurvival transcription factor within the basic leucine zipper (bZip) family that is involved in cellular differentiation and promotes cellular adaptation to stress. Recent studies have characterized the oncogenic role of ATF5 in the development of several different types of cancer, notably glioblastoma. Preclinical assessment of a systemically deliverable dominant-negative ATF5 (dnATF5) biologic has found that targeting ATF5 results in tumor regression and tumor growth inhibition of glioblastoma xenografts in mouse models. In this review, we comprehensively and critically detail the current scientific literature on ATF5 in the context of cellular differentiation, survival, and response to stressors in normal tissues. Furthermore, we will discuss how the prosurvival role of ATF5 aides in cancer development, followed by current advances in targeting ATF5 using dominant-negative biologics, and perspectives on future research.
AnnotatEd: A social navigation and annotation service for web-based educational resources

Web page annotation and adaptive navigation support are two active, but independent research directions focused on the same goal: expanding the functionality of the Web as a hypertext system. The goal of the AnnotatEd system presented in this paper has been to integrate annotation and adaptive navigation support into a single value-added service where the components can reinforce each other and create new unique attributes. This paper describes the implementation of AnnotatEd from early prototypes to the current version, which has been explored in several contexts. We summarize some lessons we learned during the development process and which defined the current functionality of the system. We also present the results of several classroom studies of the system. These results demonstrate the importance of the browsing-based information access supported by AnnotatEd and the value of both the annotation and navigation support functionalities offered by the system.
Meso- and Micro-scale Modelling in China: Wind atlas analysis for 12 meteorological stations in NE China (Dongbei)

max. 2000 char. ): As part of the “Meso-Scale and Micro-Scale Modelling in China” project, also known as the CMA component of the Sino-Danish Wind Energy Development Programme (WED), microscale modelling and analyses have been carried out for 12 meteorological stations in NE China. Wind speed and direction data from the twelve 70-m masts have been analysed using the Wind Atlas Analysis and Application Program (WAsP 10). The wind-climatological inputs are the observed wind climates derived from the WAsP Climate Analyst. Topographical inputs are elevation maps constructed from SRTM 3 data and roughness length maps constructed from Google Earth satellite imagery. The maps have been compared to Chinese topographical maps and adjusted accordingly. Summaries are given of the data measured at the 12 masts for the reference period 2009. The main result of the microscale modelling is an observational wind atlas for NE China which can be used for verification of the mesoscale modelling. In addition, the microscale modelling itself has been verified by comparing observed and modelled vertical wind profiles at the 12 sites. WAsP generally works well in Dongbei, even in its default set-up, though forested hilly and complex sites are less well modelled. Modelling of the wind profiles can be improved by using project-specific wind atlas heights and also sometimes by changing the heat flux parameters of WAsP. The southernmost sites seem to be slightly more unstable on average than the default settings in WAsP; the northern and most elevated sites seem somewhat more stable. The sensitivity of the WAsP modelling to 11 different input parameters has been investigated and it is found that the modelling is rather robust to changes in input data and parameters, when using the 70-m level anemometer as predictor. Site-specific air density (power curve) and calibrated anemometers are confirmed to be prerequisites for reliable predictions; project-specific wind atlas heights are highly recommended. Contract no.: n/a Groups own reg. no.: 1170040-01
Laminins containing the β2 and γ3 chains regulate astrocyte migration and angiogenesis in the retina

Pathologies of retinal blood vessels are among the major causes of blindness worldwide. A key cell type that regulates retinal vascular development is the astrocyte. Generated extrinsically to the retina, astrocytes migrate into the retina through the optic nerve head. Even though there is a strong correlation between astrocyte distribution and retinal vascular development, the factors that guide astrocytes into the retina remain unclear. In this study, we show that astrocytes migrate within a laminin-containing basement membrane - the inner limiting membrane. Genetic deletion of the laminin β2 and γ3 chains affects astrocyte migration and spatial distribution. We show that laminins act as haptotactic factors in vitro in an isoform-specific manner, inducing astrocyte migration and promoting astrocyte differentiation. The addition of exogenous laminins to laminin-null retinal explants rescues astrocyte migration and spatial patterning. Furthermore, we show that the loss of laminins reduces β1 integrin expression in astrocytes. Culturing laminin-null retinal astrocytes on laminin substrates restores focal localization of β1 integrin. Finally, we show that laminins containing β2 and γ3 chains regulate subsequent retinal blood vessel growth and maintain vascular integrity. These in vivo and in vitro studies demonstrate clearly that laminins containing β2 and γ3 chains are indispensable for migration and spatial organization of astrocytes and that they play a crucial role during retinal angiogenesis in vivo.