Miracle-dz/UniFAR-FTUs huggingface dataset:
Mobile monitoring with wearable photoplethysmographic biosensors.

We address both technical and clinical issues of wearable biosensors (WBS). First, design concepts of a WBS are presented, with emphasis on the ring sensor developed by the author's group at MIT. The ring sensor is an ambulatory, telemetric, continuous health-monitoring device. This WBS combines miniaturized data acquisition features with advanced photoplethysmographic (PPG) techniques to acquire data related to the patient's cardiovascular state using a method that is far superior to existing fingertip PPG sensors. In particular, the ring sensor is capable of reliably monitoring a patient's heart rate, oxygen saturation, and heart rate variability. Technical issues, including motion artifact, interference with blood circulation, and battery power issues, are addressed, and effective engineering solutions to alleviate these problems are presented. Second, based on the ring sensor technology the clinical potentials of WBS monitoring are addressed.
What Users Ask a Search Engine: Analyzing One Billion Russian Question Queries

We analyze the question queries submitted to a large commercial web search engine to get insights about what people ask, and to better tailor the search results to the users' needs. Based on a dataset of about one billion question queries submitted during the year 2012, we investigate askers' querying behavior with the support of automatic query categorization. While the importance of question queries is likely to increase, at present they only make up 3-4% of the total search traffic. Since questions are such a small part of the query stream, and are more likely to be unique than shorter queries, click-through information is typically rather sparse. Thus, query categorization methods based on the categories of clicked web documents do not work well for questions. As an alternative, we propose a robust question query classification method that uses the labeled questions from a large community question answering platform (CQA) as a training set. The resulting classifier is then transferred to the web search questions. Even though questions on CQA platforms tend to be different to web search questions, our categorization method proves competitive with strong baselines with respect to classification accuracy. To show the scalability of our proposed method we apply the classifiers to about one billion question queries and discuss the trade-offs between performance and accuracy that different classification models offer.
Enabling Persistent Autonomy for Underwater Gliders with Ocean Model Predictions and Terrain-Based Navigation

Effective study of ocean processes requires sampling over the duration of long (weeks to months) oscillation patterns. Such sampling requires persistent, autonomous underwater vehicles, that have a similarly long deployment duration. The spatiotemporal dynamics of the ocean environment, coupled with limited communication capabilities, make navigation and localization difficult, especially in coastal regions where the majority of interesting phenomena occur. In this paper, we consider the combination of two methods for reducing navigation and localization error; a predictive approach based on ocean model predictions and a prior information approach derived from terrain-based navigation. The motivation for this work is not only for real-time state estimation, but also for accurately reconstructing the actual path that the vehicle traversed to contextualize the gathered data, with respect to the science question at hand. We present an application for the practical use of priors and predictions for large-scale ocean sampling. This combined approach builds upon previous works by the authors, and accurately localizes the traversed path of an underwater glider over long-duration, ocean deployments. The proposed method takes advantage of the reliable, short-term predictions of an ocean model, and the utility of priors used in terrain-based navigation over areas of significant bathymetric relief to bound uncertainty error in dead-reckoning navigation. This method improves upon our previously published works by 1) demonstrating the utility of our terrain-based navigation method with multiple field trials, and 2) presenting a hybrid algorithm that combines both approaches to bound navigational error and uncertainty for long-term deployments of underwater vehicles. We demonstrate the approach by examining data from actual field trials with autonomous underwater gliders, and demonstrate an ability to estimate geographical location of an underwater glider to 2 km. Utilizing the combined algorithm, we are able to prescribe an uncertainty bound for navigation, and instruct the glider to surface if that bound is exceeded during a given mission.
Testing the performance of asset pricing models in different economic and interest rate regimes using individual stock returns

Using return data for all stocks continuously traded on the NYSE over the period July 1963 to December 2006, we tested the performance of the two-moment Capital Asset Pricing Model (CAPM) and the Fama French three-factor model in explaining individual stock returns. We found the performance of Fama French three-factor model to be marginally better than the CAPM.We further test the models for the significance and stability of parameters in the bull/bear periods and the Federal increasing/decreasing interest rate periods and found the performance of the two models comparable.
Biomedical text categorization with concept graph representations using a controlled vocabulary

Recent work using graph representations for text categorization has shown promising performance over conventional bag-of-words representation of text documents. In this paper we investigate a graph representation of texts for the task of text categorization. In our representation we identify high level concepts extracted from a database of controlled biomedical terms and build a rich graph structure that contains important concepts and relationships. This procedure ensures that graphs are described with a regular vocabulary, leading to increased ease of comparison. We then classify document graphs by applying a set-based graph kernel that is intuitively sensible and able to deal with the disconnectedness of the constructed concept graphs. We compare this approach to standard approaches using non-graph, text-based features. We also do a comparison amongst different kernels that can be used to see which performs better.
ETO family protein Mtgr1 mediates Prdm14 functions in stem cell maintenance and primordial germ cell formation

Prdm14 is a sequence-specific transcriptional regulator of embryonic stem cell (ESC) pluripotency and primordial germ cell (PGC) formation. It exerts its function, at least in part, through repressing genes associated with epigenetic modification and cell differentiation. Here, we show that this repressive function is mediated through an ETO-family co-repressor Mtgr1, which tightly binds to the pre-SET/SET domains of Prdm14 and co-occupies its genomic targets in mouse ESCs. We generated two monobodies, synthetic binding proteins, targeting the Prdm14 SET domain and demonstrate their utility, respectively, in facilitating crystallization and structure determination of the Prdm14-Mtgr1 complex, or as genetically encoded inhibitor of the Prdm14-Mtgr1 interaction. Structure-guided point mutants and the monobody abrogated the Prdm14-Mtgr1 association and disrupted Prdm14's function in mESC gene expression and PGC formation in vitro. Altogether, our work uncovers the molecular mechanism underlying Prdm14-mediated repression and provides renewable reagents for studying and controlling Prdm14 functions. DOI: http://dx.doi. org/10.7554/eLife.10150. 001
Industrial Machines as a Service: A Model Based on Embedded Devices and Web Services

In the last years, the maturity reached by the Information and Communications Technologies (ICT) has led us to an scenario which is suitable for facing the new business models, arisen as a consequence of the adoption of the Internet as the basic development infrastructure: strengthen of relationships between organizations and also between each organization and its customers, access to new markets, new competition models and manufacturing procedures. The research presented in this article is centred in the last field, concretely in a new method which allows an integral eBusiness model, compatible with current proposals and capable of overcoming the physical and logistical constraints that prevent the manufacturing processes from taking advantage of the whole potential offered by new technologies in this field, which are already being used by other business areas.
Associated Prime Submodules of Finitely Generated Modules

ABSTRACT Let R be a commutative ring with identity. For a finitely generated R-module M, the notion of associated prime submodules of M is defined. It is shown that this notion inherits most of the essential properties of the usual notion of associated prime ideals. In particular, it is proven that for a Noetherian multiplication module M, the set of associated prime submodules of M coincides with the set of M-radicals of primary submodules of M which appear in a minimal primary decomposition of the zero submodule of M. Also, Anderson's (1994) theorem is extended to minimal prime submodules in a certain type of modules.
Association between Ability Emotional Intelligence and Left Insula during Social Judgment of Facial Emotions

The human ability of identifying, processing and regulating emotions from social stimuli is generally referred as Emotional Intelligence (EI). Within EI, Ability EI identifies a performance measure assessing individual skills at perceiving, using, understanding and managing emotions. Previous models suggest that a brain “somatic marker circuitry” (SMC) sustains emotional sub-processes included in EI. Three primary brain regions are included: the amygdala, the insula and the ventromedial prefrontal cortex (vmPFC). Here, our aim was to investigate the relationship between Ability EI scores and SMC activity during social judgment of emotional faces. Sixty-three healthy subjects completed a test measuring Ability EI and underwent fMRI during a social decision task (i.e. approach or avoid) about emotional faces with different facial expressions. Imaging data revealed that EI scores are associated with left insula activity during social judgment of emotional faces as a function of facial expression. Specifically, higher EI scores are associated with greater left insula activity during social judgment of fearful faces but also with lower activity of this region during social judgment of angry faces. These findings indicate that the association between Ability EI and the SMC activity during social behavior is region- and emotion-specific.
Serial studies of 100 patients with chronic airway obstruction in London and Chicago

One hundred patients with chronic airway obstruction, 50 in Chicago and 50 in London, were studied by standardized techniques in 1961. The results of the initial studies, previously reported, showed that the patients in the two cities were similar; using clinical and physiological criteria based on pathological studies, the patients were divided into three types—emphysematous type A, bronchial type B, and an indeterminate type X. The patients were studied again in succeeding years, 1962-65. During this time 26 died, 19 due to their respiratory disease; these 19 patients were initially more breathless, had a higher incidence of cor pulmonale, and had more severe airway obstruction and higher carbon dioxide pressures than the remainder. Type B patients (mortality 36%) had a worse prognosis than either type A (15%) or type X (12%). Of the measurements made, high carbon dioxide pressures were most closely related (p<0·001) to mortality. During the period of follow-up about one-third of the patients who did not die became more short of breath and developed more severe airway obstruction and carbon dioxide retention: about 10% showed definite improvement in symptoms and pulmonary function. The F.E. V.1·0 declined on average by 46 ml. /year, 4·8% of the initial value; V.C. declined by 120 ml. /year, 4·0% of the initial value; mixed venous Pco2 increased 1 mm. Hg/year. The changes that occurred during this time confirmed the previously reported similarity between the patients attending the two clinics. Although the incidence of bronchitic exacerbations was similar in the two cities, such illnesses in the London patients led to more frequent and more prolonged incapacity.
Capabilities of Emotional Intelligence and Workplace Spirituality to Moderate the Effect of Task Complexity on Performance of Auditors (Case Study at Public Accounting Firm of Bali Province)

This study aimed to examine and analyze the effects of emotional intelligence and workplace spirituality to moderate the effect of task complexity on the performance of auditors of Public Accounting Firm in Bali Province. The population in this study are auditors of Public Accounting Firms in Bali registered in the Directory that is published by The Indonesian Institute of Certified Public Accountants in 2018. The sampling technique used was purposive sampling with the criteria of, among others, the auditors worked at operationally active Public Accounting Firms in Bali Province and have worked/experiences in auditing at least 1 year. A total of 63 questionnaires can be processed and the results found that task complexity gave negative effects to the performance of auditors, emotional intelligence and workplace spirituality have positive effects on performance of auditors. The results also showed that emotional intelligence is unable to moderate the effect of task complexity on performance of auditors, however, workplace spirituality is able to do this.
Distributed User Association in Energy Harvesting Dense Small Cell Networks: A Mean-Field Multi-Armed Bandit Approach

The emerging ultra-dense small cell networks (UD-SCNs) will need to combat a variety of challenges. On the one hand, massive number of devices sharing the limited wireless resources renders centralized control mechanisms infeasible due to the excessive cost of information acquisition and computation. On the other hand, to reduce the energy consumption from fixed power grid and/or battery, network entities (e.g., small cell base stations and user devices) may need to rely on the energy harvested from the ambient environment (e.g., from environmental sources). However, opportunistic energy harvesting introduces uncertainty in the network operation. In this paper, we study the distributed user association problem for energy harvesting UD-SCNs. After reviewing the state-of-the-art research, we outline the major challenges that arise in the presence of energy harvesting due to the uncertainty (e.g., limited knowledge on energy harvesting process or channel profile) as well as limited computational capacities. Finally, we propose an approach based on the mean-field multi-armed bandit games to solve the uplink user association problem for energy harvesting devices in a UD-SCN in the presence of uncertainty.
High levels of atazanavir and darunavir in urine and crystalluria in asymptomatic patients.

OBJECTIVES Atazanavir has been associated with kidney stones and renal failure. We measured urine and plasma concentrations of recent protease inhibitors (PIs) and searched for PI crystals in the urine of asymptomatic patients. METHODS A cross-sectional analysis of HIV-infected patients taking ritonavir-boosted atazanavir 300 mg/day (ATV300/r), unboosted atazanavir 400 mg/day (ATV400), ritonavir-boosted darunavir at either 800 mg/day (DRV800/r) or 1200 mg/day (DRV1200/r) or ritonavir-boosted lopinavir 800 mg/day was performed. Plasma and urine were collected and PI levels measured using HPLC. Crystals were detected and identified in urine using polarized microscopy. RESULTS PI levels were measured in 266 patients, 142 of whom were assessed for urinary crystals. Their mean age was 46 years. The mean duration of HIV infection was 10.5 years and the mean duration of the current PI-containing regimen was 22.5 months. The mean CD4 cell count was 494 cells/mm(3); 74% showed controlled HIV replication. Median urinary PI levels were 22.3, 14.3, 26.9 and 29.7 mg/L for ATV300/r, ATV400, DRV800/r and DRV1200/r, respectively, significantly higher than plasma levels, which were all <5 mg/L (P < 0.001). In contrast, median urinary lopinavir concentrrations did not significantly differ from plasma concentrations (4.2 and 6.4 mg/L, respectively; P = 0.7) and were significantly lower than those of other PIs (P < 0.001). Atazanavir crystals were found in 7/78 patients receiving ATV300/r (8.9%; 95% CI = 2.6%-15.2%) and darunavir crystals were found in 4/51 patients receiving darunavir (7.8%; 95% CI = 0.4%-15.2%). Longer exposure to atazanavir was the only risk factor associated with the presence of atazanavir crystalluria (P = 0.04). CONCLUSIONS Unlike lopinavir, atazanavir and darunavir reached high concentrations in urine. Urinary crystals were found in a few patients receiving ritonavir-boosted atazanavir or darunavir and may favour nephrolithiasis.
An Empirical Research on Users' Acceptance of Smart Phone Online Application Software

Together with the development of wireless internet technology, Smart phone online application software comes up as a new application of IT. Users’ intention and behavior determine the success and innovation orientation of the software. On the basis of UTAUT, the empirical research proves that trust beliefs and psychographics influence the acceptance of smart phone online software. Furthermore, it suggests that software providers should focus on the user’s uniqueness, enjoyment perception, perceived easiness, perceived usefulness as well as effort expectation, and finally develop the trust between users and software providers.
Gamma oscillations and schizophrenia.

In the last 2 decades, it has become apparent that brain regions communicate by coordinating the firing of populations of neurons. When neurons synchronize their firing, their rhythmic input is reflected in the extracellular field potential as brain oscillations. Rhythmic brain activity in animals and humans can be recorded using noninvasive techniques such as electroencephalography (EEG) by placing recording electrodes on the surface of the scalp and, more rarely, intracranially at the surface of a brain region, such as the temporal lobe or hippocampus. Human EEG was developed as early as the 1920s by German psychiatrist Hans Berger and has been in constant use since then. However, in the last 25 years, advances in signal processing and methods for the analysis of EEG spectra have intensified interest in the use of quantitative EEG for research purposes. Additionally, more recently developed magnetoencephalographic (MEG) techniques have shown great potential for measuring weak magnetic fields generated by rhythmic currents in the brain. With these methods, rhythmic activity of various frequencies such as delta (0–4 Hz), theta (4–8 Hz), alpha (8–12 Hz), beta (12–30 Hz) and gamma (30–200 Hz) can be detected. These neural oscillations are correlated with and are believed to play a role in normal cognitive processes including memory, attention, perceptual binding and consciousness.1
Title: Systematic Mapping of the Monkey Inferior Colliculus Reveals Enhanced Low

250 words) 21 We investigated the functional architecture of the inferior colliculus (IC) in rhesus 22 monkeys. We systematically mapped multiunit responses to tonal stimuli and noise in 23 the IC and surrounding tissue of six rhesus macaques, collecting data at evenly placed 24 locations and recording non-responsive locations to define boundaries. The results 25 show a modest tonotopically organized region (17 of 100 recording penetration 26 locations in 4 of 6 monkeys) surrounded by a large mass of tissue that, though 27 vigorously responsive, showed no clear topographic arrangement (68 of 100 penetration 28 locations). Rather, most cells in these recordings responded best to frequencies at the 29 low end of the macaque auditory range. The remaining 15 (of 100) locations exhibited 30 auditory responses that were not sensitive to sound frequency. Potential anatomical 31 correlates of functionally defined regions, and implications for midbrain auditory 32 prosthetic devices are discussed. 33
Immunotherapeutic strategies for bladder cancer

Bladder cancer is a common urologic malignancy with rising incidence in the elderly population. In most cases, bladder cancer is non-muscle-invasive at diagnosis and shows dramatically high recurrence rates, although current treatments often reduce the risk of disease progression. Immunotherapy using intravesical instillation of Bacillus Calmette-Guérin (BCG) remains the most effective therapy for patients with high risk tumors. However, BCG-therapy has important limitations including substantial adverse events and frequent treatment failure. Thus, it appears crucial to either improve or replace current therapy using new immunotherapeutic strategies. Here, we discuss the clinical trials that assessed therapeutic vaccination of bladder cancer patients using tumor associated antigens and we also argue for novel approaches arising from murine models. Vaccination routes to induce appropriate T-cell homing in the tumor site as well as the use of local immunostimulation to enhance recruitment of vaccine-induced T cells are discussed to highlight what we believe is a promising therapeutic vaccination strategy for patients with non-muscle-invasive bladder cancer.
Transcript abundance on its own cannot be used to infer fluxes in central metabolism

An attempt has been made to define the extent to which metabolic flux in central plant metabolism is reflected by changes in the transcriptome and metabolome, based on an analysis of in vitro cultured immature embryos of two oilseed rape (Brassica napus) accessions which contrast for seed lipid accumulation. Metabolic flux analysis (MFA) was used to constrain a flux balance metabolic model which included 671 biochemical and transport reactions within the central metabolism. This highly confident flux information was eventually used for comparative analysis of flux vs. transcript (metabolite). Metabolite profiling succeeded in identifying 79 intermediates within the central metabolism, some of which differed quantitatively between the two accessions and displayed a significant shift corresponding to flux. An RNA-Seq based transcriptome analysis revealed a large number of genes which were differentially transcribed in the two accessions, including some enzymes/proteins active in major metabolic pathways. With a few exceptions, differential activity in the major pathways (glycolysis, TCA cycle, amino acid, and fatty acid synthesis) was not reflected in contrasting abundances of the relevant transcripts. The conclusion was that transcript abundance on its own cannot be used to infer metabolic activity/fluxes in central plant metabolism. This limitation needs to be borne in mind in evaluating transcriptome data and designing metabolic engineering experiments.
Climate Models and the Astronomical Theory of the Ice Ages : ;̀

At tempts at determining the climatic response to perturbat ions in the Ear th ' s orbital parameters are reviewed, The relationship between equil ibrium and nonequil ibrium responses and its implications for climatic sensitivity are d iscussed in the context of an empirical model due to Imbrie and Imbrie. Some counterintui t ive features of the linear equilibrium response to the perihelion cycle in a simple energy balance model are then described in detail. The results of Nor th and Coakley and of Pollard are examined as examples of results that are, respectively, discouraging and mildly encouraging for proponents o f the astronomical theory of the ice ages. The at tempt by Suarez and Held to address some of the deficiencies in the s implest energy balance models is reviewed, followed by a brief preview of some calculations o f relevance to the ice age problem performed by Manabe and co-workers with an a tmospher ic general circulation model.