Miracle-dz/UniFAR-FTUs huggingface dataset:
Acute and 28-Day Subchronic Oral Toxicity of an Ethanol Extract of Zingiber zerumbet (L.) Smith in Rodents

The objective of this study was to evaluate the acute and subacute toxicity (28 days) of the ethanol extract of Z. zerumbet rhizomes (EEZZ) via the oral route in Wistar rats of both sexes. In the acute toxicity study, Wistar rats were administered a single dose of 15 g kg−1 of body weight by gavage, and were monitored for 14 days. EEZZ did not produce any toxic signs or deaths; the 50% lethal dose must be higher than 15 g kg−1. In the subchronic toxicity study, EEZZ was administered by gavage at doses of 1000, 2000 and 3000 mg/kg daily for 4 weeks to Wistar rats. The subacute treatment with EEZZ did not alter either the body weight gain or the food and water consumption. The hematological and biochemical analysis did not show significant differences in any of the parameters examined in female or male groups. Necropsy and histopathological examination, did not reveal any remarkable and treatment related changes. A no-observed adverse-effect level for EEZZ is 3000 mg kg−1 for rats under the conditions of this study. Hence, consumption of EEZZ for various medicinal purposes is safe.
Intralipid enhances alpha1-adrenergic receptor mediated pressor sensitivity.

The dyslipidemia in obese hypertensive persons may contribute to their increased vascular alpha-adrenergic receptor reactivity and tone. To further examine this notion, we conducted 2 studies of pressor sensitivity to phenylephrine, an alpha1-adrenergic receptor agonist, in lean normotensive subjects. In the first study (n=6), pressor responses to phenylephrine were obtained before and during a saline and heparin infusion. On another day, pressor reactivity to phenylephrine was measured before and during infusion of 20% Intralipid at 0.5 mL . m-2 . min-1 with heparin at 1000 U/h to increase lipoprotein lipase activity and raise nonesterified fatty acids (NEFAs). In the second study (n=8), baseline reactivity to phenylephrine was obtained on 2 separate days and repeated after raising NEFAs and triglycerides either with 0.8 mL . m-2 . min-1 of 20% Intralipid alone or together with heparin. The infusion of saline and heparin did not significantly change plasma NEFAs from baseline (516+/-90 versus 512+/-108 micromol/L, respectively; P=NS) or the dose of phenylephrine required to raise mean blood pressure by 20 mm Hg ([PD20PE]; 1.00+/-0.14 versus 0. 95+/-0.10 microg . kg-1 . min-1, respectively, P=NS). Intralipid at 0.5 mL . m-2 . min-1 with heparin raised plasma NEFAs to 793+/-30 micromol/L per liter (P<0.05 versus baseline) and reduced PD20PE from 1.01+/-0.10 to 0.80+/-0.09 microg . kg-1 . min-1 (P<0.05). Compared with baseline, Intralipid alone increased plasma NEFAs to 946+/-80 micromol/L (P<0.05), and NEFAs increased further with the addition of heparin to 2990+/-254 micromol/L (P<0.01). Despite an apparently greater increase of plasma NEFAs with Intralipid and heparin, Intralipid alone and together with heparin similarly reduced PD20PE. Across all study conditions, changes in levels of triglycerides and NEFAs correlated with changes in mean arterial pressure responses to phenylephrine, especially at the 0.4- microg . kg-1 . min-1 infusion rate of phenylephrine (r=0.64, P<0.01 and r=0. 54, P<0.01, respectively). These data suggest that raising levels of plasma NEFAs and/or triglycerides enhances alpha1-adrenoceptor mediated pressor sensitivity. The findings suggest that lipid abnormalities in obese hypertensives, which include elevated NEFAs and triglycerides, contribute to greater vascular alpha1-adrenergic reactivity.
Diverging Eating Psychopathology in Transgendered Eating Disorder Patients: A Report of Two Cases

This report documents two transgendered biological males who met criteria for an eating disorder, who interchangeably reported periods of endorsing masculine and feminine gender identities, allowing an exploration of how their preferred gender orientation impacted their eating disorder psychopathology. This report suggests that the divergence of body image psychopathology amongst men may be impacted by gender role orientation, which is consistent with a developing body of research.
Precambrian Tectonic Discontinuities in Western Laurentia: Broadband Seismological Perspectives on the Snowbird and Great Falls Tectonic Zones

The Snowbird Tectonic Zone (STZ) in southwestern Canada and the Great Falls Tectonic Zone (GFTZ) in northern Montana are two structural lineaments with major implications for the formation and evolution of the western North American craton. In this study, we examine the origins of these two proposed Proterozoic sutures using broadband seismic data from Alberta and USArray stations. We find substantial spatial variations in crustal structure and thickness across both the STZ and GFTZ based on an integrated analysis of P‐to‐S receiver functions, shear velocities, and potential field measurements. The STZ marks the transition from deep (NW, ~44 km) to shallow (SE, ~39 km) Moho in central Alberta. This steep Moho relief, in conjunction with elevated Vp/Vs ratios, provide compelling evidence for Proterozoic subduction and magmatism. In northern Montana, the Moho is depressed by ~6 km within the fold‐and‐thrust belts of the Trans‐Montana Orogen, where high (>1.84) Vp/Vs ratios spread along the collisional suture of the Dillion Shear Zone and terminates sharply along the reworked margin of the Wyoming craton. These observations, coupled with widespread lower crustal conversions, are concordant with a Paleoproterozoic orogeny resulting from collision(s) between Archean cratons. On the other hand, a flat Moho under major northeast striking potential field lineaments in the northernmost Montana favors an origin as a ductile shear zone, rather than suture, in the orogenic hinterland. We find evidence for crustal underplating beneath the GFTZ, though this anomalous layer is smaller than previous estimates and appears to be confined to the Trans‐Montana Orogen.
ENDOSCOPIC ULTRASOUND‐GUIDED CHOLEDOCHODUODENOSTOMY FOR PALLIATIVE BILIARY DRAINAGE IN CASES WITH INOPERABLE PANCREAS HEAD CARCINOMA

Background: Endoscopic transpapillary biliary drainage (EBD) or stenting is the gold standard treatment for inoperable malignant biliary obstruction. When the papilla cannot be traversed because of pyloric or duodenal stenosis, or the catheter cannot be introduced, or because of previous surgery, the usual alternative method is considered to be percutaneous transhepatic biliary drainage (PTBD). We herein report our experiences with four cases with inoperable pancreatic head carcinoma associated with obstructive jaundice treated by endoscopic ultrasonography‐guided biliary drainage (EUS‐BD).
The Geriatric ICF Core Set reflecting health-related problems in community-living older adults aged 75 years and older without dementia: development and validation

Abstract Purpose: The aim of the present study was to develop a valid Geriatric ICF Core Set reflecting relevant health-related problems of community-living older adults without dementia. Methods: A Delphi study was performed in order to reach consensus (≥70% agreement) on second-level categories from the International Classification of Functioning, Disability and Health (ICF). The Delphi panel comprised 41 older adults, medical and non-medical experts. Content validity of the set was tested in a cross-sectional study including 267 older adults identified as frail or having complex care needs. Results: Consensus was reached for 30 ICF categories in the Delphi study (fourteen Body functions, ten Activities and Participation and six Environmental Factors categories). Content validity of the set was high: the prevalence of all the problems was >10%, except for d530 Toileting. The most frequently reported problems were b710 Mobility of joint functions (70%), b152 Emotional functions (65%) and b455 Exercise tolerance functions (62%). No categories had missing values. Conclusion: The final Geriatric ICF Core Set is a comprehensive and valid set of 29 ICF categories, reflecting the most relevant health-related problems among community-living older adults without dementia. This Core Set may contribute to optimal care provision and support of the older population. Implications for Rehabilitation The Geriatric ICF Core Set may provide a practical tool for gaining an understanding of the relevant health-related problems of community-living older adults without dementia. The Geriatric ICF Core Set may be used in primary care practice as an assessment tool in order to tailor care and support to the needs of older adults. The Geriatric ICF Core Set may be suitable for use in multidisciplinary teams in integrated care settings, since it is based on a broad range of problems in functioning. Professionals should pay special attention to health problems related to mobility and emotional functioning since these are the most prevalent problems in community-living older adults.
A Random Trimming Approach for Obtaining High-Precision Embedded Resistors

Embedded resistors will potentially allow electronic applications to cost less and perform better. However, it is difficult to fabricate embedded resistors to the correct resistance value, so embedded resistors are often fabricated with a lower value and then trimmed to raise the resistance to the desired value. A computer simulation for the trimming process of an embedded resistor has been developed that has been verified and calibrated against experimental results. A study of embedded resistors containing random voids of varying size has been performed. A new trimming strategy in which the trims are made randomly (rather than conventional L-shaped trims) is proposed and the results of the analysis demonstrate that single-dive trimming combined with random trimming allows higher precision embedded resistors to be obtained than conventional trimming patterns.
Feasibility analysis of messages for on-chip networks using wormhole routing

The feasibility of a message in a network concerns if its timing property can be satisfied without jeopardizing any messages already in the network to meet their timing properties. We present a novel feasibility analysis for real-time (RT) and nonrealtime (NT) messages in wormhole-routed networks on chip. For RT messages, we formulate a contention tree that captures contentions in the network. For coexisting RT and NT messages, we propose a simple bandwidth partitioning method that allows us to analyze their feasibility independently.
Childhood Language Skills and Adult Literacy: A 29-Year Follow-up Study

OBJECTIVE: Our aim was to assess the longitudinal trajectory of childhood receptive language skills and early influences on the course of language development. METHODS: Drawing on data collected for a nationally representative British birth cohort, the 1970 British Cohort Study, we examined the relationship between directly assessed early receptive language ability, family background, housing conditions, early literacy environment, and adult literacy skills. A sample of 11349 cohort members who completed the English Picture Vocabulary Test at 5 years of age were studied again at 34 years of age, when they completed a direct assessment of their basic literacy skills. We contrasted experiences of individuals with language problems at age 5 against the experiences of those with normal language skills at that age, assessing the role of socioeconomic family background and early literacy environment in influencing the longitudinal course of developmental language problems. Statistical comparisons of rates with χ2 tests at P values of . 001, . 01, and . 05 were made, as well as multivariate logistic regressions. RESULTS: Cohort members with receptive language problems at age 5 had a relatively disadvantaged home life in childhood, both in terms of socioeconomic resources and the education level of their parents, but also regarding their exposure to a stimulating early literacy environment. Although there is significant risk for poor adult literacy among children with early language problems, the majority of these children develop competent functional literacy levels by the age of 34. Factors that reduce the risk for persistent language problems include the child being born into a working family, parental education beyond minimum school-leaving age, advantageous housing conditions, and preschool attendance. CONCLUSION: Effective literacy-promoting interventions provided by pediatric primary care providers should target both children and parents.
PMSat: a parallel version of MiniSAT

Parallel computing has become an affordable reality forcing a shift in the programming paradigm from sequential to concurrent applications, specially those who demand much computational power or with large search spaces like SAT-solvers. In this context we present the research, planning and implementation of PMSat: a parallel version of MiniSAT with MPI (Message Passing Interface) technology, to be executed in clusters or grids of computers. The main features of the program are described: search modes, search space pruning and share of learnt clauses. An analysis of its performance and load balance is also presented.
The flow of blood to lymph nodes and its relation to lymphocyte traffic and the immune response

The blood flow to individual lymph nodes of sheep and rabbits has been determined with 85Sr-labeled microspheres. A popliteal node of the sheep received 0.014% of the cardiac output and a comparable node in the rabbit 0.011%. A sheep lymph node weighing 1 g received an average of 24 ml/h of blood. It was calculated that there was a highly selective removal of lymphocytes by the node and that an equivalent to one in every four lymphocytes that entered a normal lymph node migrated out of the blood, through the substance of the node, and into the efferent lymph. During the immune response to either allogeneic lymphocytes or tuberculin, the blood flow to sheep lymph nodes, even without considering the increase in node weight, increased an average of fourfold. During the primary immune response in the rabbit to keyhole limpet hemocyanin, the blood flow increased threefold. The increase in blood flow preceded the antigen-induced increase in lymphocyte traffic recorded in the efferent lymph. The early phase of increased blood flow was considered to be due to hyperemia, whereas the latter phase had a significant angiogenesis component. It was calculated that an equivalent to 60% of the entire mobilizable pool of lymphocytes could pass through an average lymph node in the blood during an immune response lasting 5 days.
Numerical solution of free-boundary problems in fluid mechanics. Part 2. Buoyancy-driven motion of a gas bubble through a quiescent liquid

In this paper numerical results are presented for the buoyancy-driven rise of a deformable bubble through an unbounded quiescent fluid. Complete solutions, including the bubble shape, are obtained for Reynolds numbers in the range 1 ≤ R ≤ 200 and for Weber numbers up to 20. For Reynolds numbers R ≤ 20 the shape of the bubble changes from nearly spherical to oblate-ellipsoidal to spherical-cap depending on Weber number; at higher Reynolds numbers ‘disk-like’ and ‘saucer-like’ shapes appear at W = O(10). The present results show clearly that flow separation may occur at a smooth free surface at intermediate Reynolds numbers; this fact suggests a qualitative explanation of the often-observed irregular (zigzag or helical) paths of rising bubbles.
Multilingual Speech-to-Speech Translation System: VoiceTra

This study presents an overview of VoiceTra, which was developed by NICT and released as the world's first network-based multilingual speech-to-speech translation system for smartphones, and describes in detail its multilingual speech recognition, its multilingual translation, and its multilingual speech synthesis in regards to field experiments. We show the effects of system updates using the data collected from field experiments to improve our acoustic and language models.
Agent-Based Simulation of the Trust and Tracing Game for Supply Chains and Networks

This paper describes a multi-agent simulation model of the Trust And Tracing game. The Trust And Tracing game is a gaming simulation for human players, developed as a research tool for data collection on human behaviour in food supply chains with asymmetric information about food quality and food safety. Important issues in the game are opportunistic behaviour (deceit), trust and institutional arrangements for enforcing compliance. The goal is to improve the understanding of human decision making with respect to these issues. To this end multi-agent simulation can be applied to simulate the effect of models of individual decision making in partner selection, negotiation, deceit and trust on system behaviour. The combination of human gaming simulation and multi-agent simulation offers a basis for model refinement in a cycle of validation, experimentation, and formulation of new hypotheses. This paper describes a first round of model formulation and validation. The models presented are validated by a series of experiments performed by the implemented simulation system, of which the outcomes are compared on aggregated level to the outcomes of games played by humans. The experiments cover in a systematic way the important variations in parameter settings possible in the game and in the characteristics of the agents. The simulation results show the same tendencies of behaviour as the observed human games.
Aggregate Economic Shocks, Child Schooling and Child Health

Do aggregate economic shocks, such as those caused by macroeconomic crises or droughts, reduce child human capital? The answer to this question has important implications for public policy. If shocks reduce investments in children, they may transmit poverty from one generation to the next. This paper uses a simple framework to analyze the effects of aggregate economic shocks on child schooling and health. It shows that the expected effects are ambiguous, because of a tension between income and substitution effects. The paper then reviews the recent empirical literature on the subject. In richer countries, like the United States, child health and education outcomes are counter-cyclical: they improve during recessions. In poorer countries, mostly in Africa and low-income Asia, the outcomes are pro-cyclical: infant mortality rises, and school enrollment and nutrition fall during recessions. In the middle-income countries of Latin America, the picture is more nuanced: health outcomes are generally pro-cyclical, and education outcomes counter-cyclical. Each of these findings is consistent with the simple conceptual framework. The paper discusses possible implications for expenditure allocation.
Influence of Wind Direction on Thermodynamic Properties and Arctic Mixed‐Phase Clouds in Autumn at Utqiaġvik, Alaska

Seven years of autumnal ground‐based observations (September–November 2002–2008) at the U.S. Department of Energy Atmospheric Radiation Measurement North Slope of Alaska site have been analyzed for addressing the occurrence frequency and macrophysical and microphysical properties of Arctic mixed‐phase clouds (AMC), as well as the relationship between environmental parameters and AMC properties. In September and October, AMC occurrence frequency is 20–30% lower during a southerly wind when compared to the other wind directions; in November, the variation of AMC occurrence frequency with wind direction is small. The mean liquid water path in November is about half of that in October and September. When the surface is snow free, temperature (T) and specific humidity (q) profiles during a northerly wind are warmer and moister than those for the southerly wind. Northerly wind profiles have a higher relative humidity to ice (RHi) and lower atmosphere stability. Furthermore, the AMC occurrence frequency has a positive relationship with RHi and a negative relationship with stability. These two points may explain the lower AMC occurrence frequency during a southerly wind. During a northerly wind, AMCs have larger radar reflectivity, wider spectrum width, and larger Doppler velocity signatures. The stronger precipitation for AMC during a northerly wind is possibly due to the cleaner air masses from the ocean (north). With the same amount of q, the radar spectrum width has a higher frequency in the larger bins during a northerly wind. Both T, q, and radar reflectivity, radar spectrum width profiles show evidence of deposition in the sub‐cloud layer in September and October.
Mitomycin C Influence on Inhibition of Cellular Proliferation and Subsequent Synthesis of Type I Collagen and Laminin in Primary and Recurrent Pterygia

The purpose was to investigate the biological effects of mitomycin C (MMC) on the inhibition of cellular proliferation and the subsequent synthesis of extracellular matrix like type I collagen (PIP) and laminin on primary and recurrent pterygia. The 3H-thymidine assay for cellular proliferation was consistent with the MMC dose and time response of both pterygia. The cellular inhibitory effect of MMC was greater on recurrent pterygial cells than primary ones. The inhibition of laminin by MMC followed the dose and time-response curves, with a stronger effect found in recurrent pterygial cells, but no significant difference between the two types concerning type I collagen synthesis. The inhibition of fibroblast proliferation and subsequent synthesis of laminin by MMC was more marked in recurrent pterygium than the primary one.
Catheter-Directed Thrombolysis Along with Mechanical Thromboaspiration versus Anticoagulation Alone in the Management of Lower Limb Deep Venous Thrombosis—A Comparative Study

Abstract Catheter-directed thrombolysis (CDT) with assisted mechanical thrombolysis is now considered as the standard of medical care for deep vein thrombosis (DVT). The study was conducted to describe the immediate and long-term (6 months) safety and effectiveness of CDT in patient with lower limb DVT compared with the routine anticoagulation alone. All 12 to 85 years old patients with recent (0–8 weeks) DVT were included. In CDT group, thrombus was aspirated mechanically and streptokinase (STK) was given along with unfractionated heparin (UFH). After 6 months, deep venous patency and postthrombotic syndrome (PTS) was assessed by using duplex ultrasound and Villalta scale, respectively. Among 51 patients with completed data, 25 patients were allocated additional CDT given for a mean duration of 108 ± 32 hours and 26 patients were allocated standard treatment alone. Grade III (complete) lysis was achieved in 37% patients and grade II (50–90%) lysis in 63% of patients. Patients with partial lysis underwent percutaneous transluminal angioplasty and/or venous stenting. After 6 months, iliofemoral patency was found in 20 (80%) in the CDT group versus 7 (23%) in anticoagulation alone group (p < 0.01). PTS was seen in 5 (20%) in the CDT group versus 19 (77%) in anticoagulation alone group (p < 0.01). We conclude that CDT and conventional manual aspiration thrombectomy are an effective treatment for lower extremity DVT. STK infusion can be safely given up to 6 days. As addition of UFH can cause thrombocytopenia, so daily monitoring of complete blood counts is needed during CDT.