Miracle-dz/UniFAR-FTUs huggingface dataset:
Medicinal practice in Western science and African traditional thought: a comparative analysis

This paper attempts a philosophical comparison of the traditional African medicinal system vis‐à‐vis what obtains in Western medicinal practice. The methodology is comparative and analytical. Its comparative character derives from the fact that it assesses the goal of medicinal practice within the framework of two theoretical modes of thought, that is, Western science and traditional African thought. The study explores the tools of conceptual analysis to look at the meaning, foundations, components and methodology of medicinal practice in Western science and traditional African thought, with the aim of showing their differences and similarities. The findings of the study reveal that the goal of medicinal practice, in both of the two theoretical modes of thought, is to heal, protect, and make human life valuable. Hence, medicinal practice in Western science and traditional African thought are not mutually exclusive of each other. The paper argues further that the traditional perception of health with its metaphysical presupposition makes traditional medicine more functional and more germane to human practical needs than that to be found in Western medicinal practice, which has pure science has its canon. However, in order to enhance an effective health care delivery system in contemporary societies, the paper concludes with the need to augment, and perhaps, integrate both orthodox and alternative medicinal practices for better results.
Efficient Non-greedy Optimization of Decision Trees

Decision trees and randomized forests are widely used in computer vision and machine learning. Standard algorithms for decision tree induction optimize the split functions one node at a time according to some splitting criteria. This greedy procedure often leads to suboptimal trees. In this paper, we present an algorithm for optimizing the split functions at all levels of the tree jointly with the leaf parameters, based on a global objective. We show that the problem of finding optimal linear-combination (oblique) splits for decision trees is related to structured prediction with latent variables, and we formulate a convex-concave upper bound on the tree's empirical loss. Computing the gradient of the proposed surrogate objective with respect to each training exemplar is O(d2), where d is the tree depth, and thus training deep trees is feasible. The use of stochastic gradient descent for optimization enables effective training with large datasets. Experiments on several classification benchmarks demonstrate that the resulting non-greedy decision trees outperform greedy decision tree baselines.
Mixed Methods in International Collaborative Research: The Experiences of the International Study of Parents, Children, and Schools

The power of a mixed-methods approach combining anthropological and psychological theories and methods is demonstrated through the experiences of the International Study of Parents, Children, and Schools, a collaborative project involving teams of researchers from seven Western countries. The developmental niche framework of Super and Harkness proved useful for integrating multiple methods to understand the context of children’s early development at home and at school. Several parts of the study are presented as illustrations: the development and application of a common list of descriptors for coding parents’ discourse about their children; the construction of a derived etic form of a child temperament questionnaire; the discovery and exploration of ideas and practices related to parent-child co-sleeping; and the identification of cultural themes across various kinds of data. The authors conclude that a combination of anthropological and psychological methods can enrich understanding of children’s development in various cultural settings.
Fatty acid synthase inhibition results in a magnetic resonance–detectable drop in phosphocholine

Expression of fatty acid synthase (FASN), the key enzyme in de novo synthesis of long-chain fatty acids, is normally low but increases in cancer. Consequently, FASN is a novel target for cancer therapy. However, because FASN inhibitors can lead to tumor stasis rather than shrinkage, noninvasive methods for assessing FASN inhibition are needed. To this end, we combined 1H, 31P, and 13C magnetic resonance spectroscopy (MRS) (a) to monitor the metabolic consequences of FASN inhibition and (b) to identify MRS-detectable metabolic biomarkers of response. Treatment of PC-3 cells with the FASN inhibitor Orlistat for up to 48 h resulted in inhibition of FASN activity by 70%, correlating with 74% inhibition of fatty acid synthesis. Furthermore, we have determined that FASN inhibition results not only in lower phosphatidylcholine levels but also in a 59% drop in the phospholipid precursor phosphocholine (PCho). This drop resulted from inhibition in PCho synthesis as a result of a reduction in the cellular activity of its synthetic enzyme choline kinase. The drop in PCho levels following FASN inhibition was confirmed in SKOV-3 ovarian cancer cells treated with Orlistat and in MCF-7 breast cancer cells treated with Orlistat as well as cerulenin. Combining data from all treated cells, the drop in PCho significantly correlated with the drop in de novo synthesized fatty acid levels, identifying PCho as a potential noninvasive MRS-detectable biomarker of FASN inhibition in vivo. [Mol Cancer Ther 2008;7(8):2556–65]
Distortion-transmission trade-off in real-time transmission of Markov sources

The problem of optimal real-time transmission of a Markov source under constraints on the expected number of transmissions is considered, both for the discounted and long term average cases. This setup is motivated by applications where transmission is sporadic and the cost of switching on the radio and transmitting is significantly more important than the size of the transmitted data packet. For this model, we characterize the distortion-transmission function, i.e., the minimum expected distortion that can be achieved when the expected number of transmissions is less than or equal to a particular value. In particular, we show that the distortion-transmission function is a piecewise linear, convex, and decreasing function. We also give an explicit characterization of each vertex of the piecewise linear function. The results are illustrated using an example of a birth-death Markov chain.
A Synoviocyte Model for Osteoarthritis and Rheumatoid Arthritis: Response to Ibuprofen, Betamethasone, and Ginger Extract—A Cross-Sectional In Vitro Study

This study aimed at determining if synovial cell cultures from rheumatoid arthritis (RA), osteoarthritis (OA), and healthy controls (HC) differ and are suitable disease models in pharmacological studies, and tested their response to some anti-inflammatory drugs. Synovial cells were isolated from synovial membrane or joint fluid. Cells were cultivated and exposed to no or TNF-α stimulation without, or in the presence of, betamethasone, ibuprofen, or a standardized ginger extract. Concentrations of a panel of cytokines, growth factors, and chemokines were mapped for each culture and condition. Our cells secreted an increased amount of the cytokines IL-1β, IL-6, and IL-8 in response to TNF-α stimulation in all conditions. OA cells showed a higher IL-6 and IL-8 and a lower IL-1β production, when not stimulated, than RA and HC cells, which were similar. TNF-α stimulation caused similar IL-1β, IL-6, and IL-8 release in all groups. Ibuprofen showed no effect on cytokine production, while ginger extract was similar to betamethasone. Ginger extract was as effective an anti-inflammatory agent as betamethasone in this in vitro model. Cultured fibroblast-like synoviocytes from OA and RA subjects promise to be a useful pharmacological disease model, but further studies, to support results from such a model are needed.
Novel partial agonists for the histamine H(3) receptor with high in vitro and in vivo activity.

Novel branched N-alkylcarbamates and aliphatic ethers derived from 3-(1H-imidazol-4-yl)propanol were prepared. The compounds were investigated on two functional histamine H(3)-receptor assays. Some compounds displayed partial agonist activity on synaptosomes of rat brain cortex but behaved as pure competitive antagonists on the guinea pig ileum. Under in vivo conditions after po application to mice, some of the compounds showed partial or full agonist activity. Highest in vivo potency was found for the 3,3-dimethylbutyl ether 10 (ED(50) = 0.29 mg/kg, full intrinsic activity). These novel agonists are structurally diverse from classical aminergic histamine H(3)-receptor agonists (e.g., (R)-alpha-methylhistamine, imetit) as they lack a basic moiety in the side chain, which is supposed to be important for the activation of the receptor protein. The selectivity for the histamine H(3) receptor was proven by determination of H(1)- and H(2)-receptor activity on functional assays of the guinea pig.
“Relic of 1840” or founding document? The treaty, the tribunal and concepts of time

Abstract This paper has two main objectives. First, it examines the ways in which the Waitangi Tribunal considers the notion of “time” (and its corollary “timelessness") in relation to the Treaty of Waitangi. The Tribunal has increasingly emphasised the timeless‐ness of the Treaty, its ability to transcend temporal notions of time, and the implications of this for the relationship between the Treaty partners, Maori and the Crown. Second, it compares these tendencies with contemporary Maori ideas of time, as they are presented in the modern Treaty claims process. It is argued that the Tribunal, especially in its more recent reports, has signalled a marked shift in its acknowledgment of Maori concepts of time. Its published reports from 1999 onwards show more appreciation not for only for Maori understandings of the Treaty relationship, but for Maori values and concepts which, by their articulation and inclusion in the hearing process, test orthodox and dominant assumptions regarding the nature of change over time. Some broader trends may also be observed. Since the 1980s, there have been numerous references to the Treaty and its principles in statutory law, Waitangi Tribunal reports, and Deeds of Settlement ratified by successive New Zealand governments. Furthermore, there has been increasing (but by no means universal) recognition of the Treaty as a “developing social contract”, rather than a static historical document, with much of the impetus for such an interpretation coming from findings and recommendations of the Waitangi Tribunal.
Indirect Consequences of Recreational Fishing in Freshwater Ecosystems: An Exploration from an Australian Perspective

Recreational fishing in freshwater ecosystems is a popular pastime in Australia. Although most native fish are endemic, the fauna is depauperate compared to any landmass of similar size. With commercial fishing no longer a major industry in the country’s freshwaters, the future sustainability of these ecosystems will depend heavily on the actions of recreational fishers. However, there has been limited focus on the consequences of recreational fishing in freshwaters. There is particularly a dearth of information on the indirect consequences of fishers on the waterbodies they depend on for their sport. After outlining the respective trends in commercial and recreational fishing in Australia as a basis for placing the sport in context, the indirect impacts of fishers on water quality, movement (walking, off-road vehicles), the introduction/translocation of fauna (particularly fish), the dispersal of flora and the transmission of fish disease and pathogens are reviewed. It is concluded that with the decline of commercial fishing, the competition between commercial fin-fishing and recreational fishing is negligible, at least throughout most of the country. It is also concluded that each of the issues addressed has the potential to be detrimental to the long-term sustainability of the freshwater ecosystems that the fishers depend on for their recreation. However, information on these issues is scant. This is despite the current and predicted popularity of freshwater recreational fishing continuing to increase in Australia. Indeed, there has been insufficient quantitative assessment of the impacts to even determine what is required to ensure a comprehensive, adequate and representative protection of these freshwater ecosystems. To underpin the sustainability of inland recreational fishing in the country, it was concluded that research is required to underpin the development and implementation of appropriate policies. The alternative is that the integrity and biodiversity loss of these ecosystems will ultimately result in their collapse before the indirect consequences of recreational fishing have been directly assessed and appropriately protected. However, the lack of protection of wetlands is not restricted to Australia; there is a deficit of freshwater protected areas worldwide.
Pharmacological Treatment of Insomnia Symptoms in Individuals with Substance Use Disorders in Spain: A Quasi-Experimental Study

ABSTRACT Introduction: Pharmacological treatment of insomnia in patients with addictions has been hardly investigated and there are few researches about it in an inpatient detoxification. The aim of this study was to describe the outcomes of the pharmacological treatment of insomnia in SUD patients admitted to a detoxification unit in Spain, with a focus on the primary substance of abuse and co-occurring mental disorders. Methods: A quasi-experimental study was conducted in 481 addicted in patients, who were admitted for substances detoxification in Vall d´Hebron University Hospital, Barcelona, Spain, from 2010 to 2015. The patients underwent systematic evaluation of axes I and II psychiatric disorders (SCID-I, SCID-II, and CAADID). Insomnia was evaluated using a night time sleep log. Substance-dependent patients, who had insomnia during hospital detoxification, received a psychotropic medication with hypnotic effect, keeping the regular clinical practice without randomization. Results: At discharge, insomnia was considered to have been alleviated in 63.8% (n = 204) of patients while 36.2% (n = 116) of patients remained with insomnia disturbances. Comparing hypnotic treatments it was observed that mirtazapine and clotiapine were the treatment that corrected the insomnia more frequently. Discussion: Since insomnia is not corrected in all patients, it should be further investigated in medications with hypnotic purpose. Based on the results of this work, randomized clinical trials might be proposed.
Reachability-based matroid-restricted packing of arborescences Csaba Király ? and Zoltán Szigeti ? ?

The fundamental result of Edmonds [5] started the area of packing arborescences and the great number of recent results shows increasing interest of this subject. Two types of matroid constraints were added to the problem in [2, 3, 9], here we show that both contraints can be added simultaneously. This way we provide a solution to a common generalization of the reachability-based packing of arborescences problem of the first author [14] and the matroid intersection problem of Edmonds [4].
Proteasome Activator PA200 Is Required for Normal Spermatogenesis

ABSTRACT The PA200 proteasome activator is a broadly expressed nuclear protein. Although how PA200 normally functions is not fully understood, it has been suggested to be involved in the repair of DNA double-strand breaks (DSBs). The PA200 gene (Psme4) is composed of 45 coding exons spanning 108 kb on mouse chromosome 11. We generated a PA200 null allele (PA200Δ) through Cre-loxP-mediated interchromosomal recombination after targeting loxP sites at either end of the locus. PA200Δ/Δ mice are viable and have no obvious developmental abnormalities. Both lymphocyte development and immunoglobulin class switching, which rely on the generation and repair of DNA DSBs, are unperturbed in PA200Δ/Δ mice. Additionally, PA200Δ/Δ embryonic stem cells do not exhibit increased sensitivity to either ionizing radiation or bleomycin. Thus, PA200 is not essential for the repair of DNA DSBs generated in these settings. Notably, loss of PA200 led to a marked reduction in male, but not female, fertility. This was due to defects in spermatogenesis observed in meiotic spermatocytes and during the maturation of postmeiotic haploid spermatids. Thus, PA200 serves an important nonredundant function during spermatogenesis, suggesting that the efficient generation of male gametes has distinct protein metabolic requirements.
Individual entrepreneurial orientation: development of a measurement instrument

Purpose – The purpose of this paper is to develop a measurement instrument for individual entrepreneurial orientation to be used to measure the entrepreneurial orientation of students and other individuals.Design/methodology/approach – A measure of Individual Entrepreneurial Orientation (IEO) was generated, validated, and then tested on 1,100 university students. The items for the scale were based on the definitions of the five entrepreneurial orientation dimensions presented by Lumpkin and Dess. Final analysis of the IEO items using exploratory factor analysis resulted in reliable and valid measures for three of the dimensions.Findings – The scale development process for IEO resulted in three distinct factors that demonstrated reliability and validity: innovativeness, risk‐taking, and proactiveness, which statistically correlated with measures of entrepreneurial intention.Research limitations/implications – The study comprised students at one university in the central southern USA and should be extended .
Emerging therapeutic options for acute migraine: focus on the potential of lasmiditan

The serotonin receptor agonist triptan drugs (5-HT1B/1D receptor agonists) have been in use for over 20 years in the abortive management of migraine. Although clearly effective, their ability to produce vasoconstriction in cerebral and coronary arteries, thought to be mediated by their high affinity for the 5-HT1B receptor, has been a limitation to their use in certain patient populations. Variable potency triptan binding at the 5-HT1F receptor occurs in addition to binding at the 5-HT1B and 5-HT1D receptors. A more selective serotonin agonist without 5-HT1B-mediated vasoconstriction might prove efficacious yet safer. The 5-HT1F receptor has been targeted as a site of action for such a drug. In experimental models, 5-HT1F receptor agonists have been shown to block neurogenic inflammation and c-Fos expression in neural tissue and, as well, show no evidence of vasoconstriction in vascular tissue models in vitro. In clinical trials, efficacy in the abortive management of migraine has been established. Lasmiditan (LY573144), a selective 5-HT1F receptor agonist (K1=2.21 μM), showed efficacy in its primary endpoint, with a 2-hour placebo-subtracted headache response of 28.8%, though with frequent reports of dizziness, paresthesias, and vertigo. Study results support an emerging central neuronal mechanism of migraine pathophysiology. This review traces the history and use of 5-HT1F receptor agonists, now referred to as neurally acting anti-migraine agents in migraine management.
A frequency-domain entropy-based detector for robust spectrum sensing in cognitive radio networks

Sensitivity to noise uncertainty is a fundamental limitation of current spectrum sensing strategies in cognitive radio networks (CRN). Because of noise uncertainty, the performance of traditional detectors such as matched filters, energy detectors, and even cyclostationary detectors deteriorates rapidly at low Signal-to-Noise Ratios (SNR). To counteract noise uncertainty, a new entropy-based spectrum sensing scheme is introduced in this letter. The entropy of the sensed signal is estimated in the frequency domain with a probability space partitioned into fixed dimensions. It is proven that the proposed scheme is robust against noise uncertainty. Simulation results confirm the robustness of the proposed scheme and show 6dB and 5dB performance improvement compared with energy detectors and cyclostationary detectors, respectively. In addition, the sample size is significantly reduced compared to an energy detector.
Single Integration and Spread of a Copia-Like Sequence Nested in rDNA Intergenic Spacers of Allium cernuum (Alliaceae)

The 35S ribosomal DNA (rDNA) intergenic spacer (IGS) of Allium cernuum is examined. Initial sequencing of IGS clones revealed that some rDNA units contain a truncated retrotransposon sequence most similar to members of the Copia superfamily. Fluorescence in situ hybridisation (FISH) to metaphase chromosomes indicates that this element is dispersed along both pairs of major rDNA arrays. Southern hybridisation confirmed the presence of this ‘relic’ Copia-like element in more than 10% of 35S rDNA units, in the same position within the IGS. To measure the intragenomic divergence of the relic retroelement and its flanking sequences amongst different rDNA units, a 1.1-kb region was amplified and cloned. These data collectively point to a single origin for units containing the putative retrotransposon fragment. It is likely that units containing the putative retroelement increased in copy number and dispersed via rDNA homogenisation mechanisms, rather than by multiple retrotransposition events.
Psychosocial Impact Among Sudanese Women with Vesico-Vaginal Fistula

Vesicovaginal fistula (VVF) is an abnormal fistulous extension between the urinary bladder and The vagina. The objective of this study was to investigate psychosocial impact among Sudanese women suffering from Vesicovaginal fistula. This cross-sectional descriptive study was conducted among one hundred patients with Vesicovaginal fistula admitted at the fistula ward in Khartoum Teaching Hospital during the period from December 2007 to March 2008. The participants were invited to sign a written informed consent, and a pre-tested questionnaire was used to collect the following information: sociodemographic data, the level of education, marital status, socioeconomic status, and the family attitude towards the patients. The Ethical Committee of the Sudan Specialization Board approved the research, and the Statistical Package for Social Sciences was used for the data analysis. A P-value of, < 0.05 was considered significant. The study revealed that more than two third of patients lie in age group (18-23) years. 71% of patients were valid married, 42% of patients were depressed, 26% of patients were either divorced or separated. 61% of patients were illiterate, and 69% were of low socioeconomic status. Family neglect was evident in 6% of patients while criticism was observed in 1%. Women with vesicovaginal fistula were young, of low socio-economic class, and relatively high level of depression, divorce rate, and separation.
The Challenge of "Good Enough" Software

This article is a slightly updated version of the the original that was published in American Programmer magazine in 1995. I’ve changed some of my vocabulary, since 1995, but not the essence of my beliefs on this subject. These ideas are rooted in my experiences at Apple Computer in the late 80’s, and Borland in the early nineties. This article was treated as a counter-culture rant in 1995. But today, the agile development movement, which exemplifies these ideas, is well established. See also Good Enough Quality: Beyond the Buzzword, and A Framework for Good Enough Testing. Find them at my website: www.satisfice. com.