Miracle-dz/UniFAR-FTUs huggingface dataset:
Single-pulse terahertz coherent control of spin resonance in the canted antiferromagnet YFeO3, mediated by dielectric anisotropy

We report on the coherent control of terahertz (THz) spin waves in a canted antiferromagnet yttrium orthoferrite, YFeO${}_{3}$, associated with a quasiferromagnetic (quasi-FM) spin resonance at a frequency of 0.3 THz, using a single-incident THz pulse. The spin resonance is excited impulsively by the magnetic field component of the THz pulse. The intrinsic dielectric anisotropy of YFeO${}_{3}$ in the THz range allows for coherent control of both the amplitude and the phase of the excited spin wave. The coherent control is based on simultaneous generation of two interfering phase-shifted spin waves whose amplitudes and relative phase, dictated by the dielectric anisotropy of the YFeO${}_{3}$ crystal, can be controlled by varying the polarization of the incident THz pulse with respect to the crystal axes. The spatially anisotropic decay of the THz-excited FM spin resonance in YFeO${}_{3}$, leading to an increasingly linear polarization of the THz oscillation at the spin resonance frequency, suggests a key role of magnon--phonon coupling in spin-wave energy dissipation.
The blockchain litmus test

Bitcoin's underlying blockchain database is a novel approach to recordkeeping that has the potential to decentralize big data. Bitcoin's success has inspired a multitude of spinoff projects hoping to use blockchain as a distributed database for records-management innovation in other fields. Misconceptions and exaggerations about blockchain and its capabilities are pervasive in the media. Drawing on perspectives from archival science, dependable computing, and secure computing, this paper surveys current applications, research, and critiques of blockchain to provide an objective assessment of its benefits and limitations. Based on the findings of the survey, this paper proposes three criteria that predict success for blockchain-based data management projects, briefly: dependability, security, and trust.
LncSOX4 serves an oncogenic role in the tumorigenesis of epithelial ovarian cancer by promoting cell proliferation and inhibiting apoptosis

Epithelial ovarian cancer is one of the primary causes of gynecological cancer mortality. Increasing evidence has suggested that long non-coding RNAs (lncRNAs) may serve a pivotal role in cancer development. To determine whether Lnc SRY-box 4 (SOX4), an lncRNA, promotes the self-renewal of liver tumor cells and contributes to the development of epithelial ovarian cancer, the present study investigated the expression of LncSOX4 in clinical epithelial ovarian cancer tissues and non-cancer controls by reverse transcription-quantitative polymerase chain reaction analysis. In addition, siRNA targeting LncSOX4 was designed and transfected into epithelial ovarian cancer cells to further assess the effect of knocking out LncSOX4 on cellular apoptosis, cell viability, proliferation and the cell cycle. The results demonstrated that the LncSOX4 expression level was significantly upregulated in epithelial ovarian cancer tissues (3.98 vs. 1.71, P<0.001). Silencing LncSOX4 in the SKOV3 and OVCAR3 cell lines significantly impaired cell proliferation (P<0.001). Cell cycle assays revealed that the proportion of cells in the G0/G1 phase increased significantly, whereas those in the S phase and G2/M phase decreased. Apoptosis rate additionally increased following knockdown of LncSOX4 in the two cell lines. Furthermore, it was observed that an increased LncSOX4 expression level was positively associated with larger tumor sizes, more advanced tumor grade and more distant metastases.
The Chinese medicine, Jianpi Huayu Decoction, inhibits the epithelial mesenchymal transition via the regulation of the Smad3/Smad7 cascade.

BACKGROUND Hepatocellular carcinoma (HCC) is one of the most common and aggressive malignant tumors in the world. In China, traditional medicine is commonly used in the treatment of cancer. Among these medicines, Jianpi Huayu Decoction (JHD) is a typical clinical prescription against multiple tumors. However, the exact function and targets of JHD are currently unknown. The aim of this study is to assess the efficacy of JHD against HCC. METHODS AND RESULTS Hepatic carcinoma SMMC7221 cells were treated with JHD drug-serum in a dose- and time-dependent manner. Real-time PCR (RT-PCR), western-blot (WB), and immunofluorescence microscopy revealed that JHD increased both the mRNA and protein levels of Smad7 and decreased the protein level of p-Smad3. It subsequently increased the E-cadherin expression level and decreased those of N-cadherin and Vimentin. Metastasis and invasion were eventually inhibited, as determined by the wound healing and transwell invasion assays. Treatment of Tanshinone IIA (Tan IIA) showed similar results as JHD, indicating that it is most likely the main functional drug monomer of JHD. The in vivo assay in nude mice also revealed the efficacy of JHD to inhibit epithelial mesenchymal transition (EMT). CONCLUSION JHD was shown to be an effective therapeutic strategy against HCC.
Uplift modeling for clinical trial data

Traditional classification methods predict the class probability distribution conditional on a set of predictor variables. Uplift modeling, in contrast, tries to predict the difference between class probabilities in the treatment group (on which some action has been taken) and the control group (not subjected to the action) such that the model predicts the net effect of the action. Such an approach seems to be well suited to analysis of clinical trial data and to allow for discovering groups of patients for which the treatment is most beneficial. One of the purposes of this paper is to verify this claim experimentally. Additionally, we present an approach to uplift modeling which allows for application of standard probabilistic classification models, such as logistic regression, in the uplift setting. Further, we extend the approach such that standard classification models built on the treatment and control datasets can be incorporated in a manner similar to semisupervised learning in order to improve prediction accuracy. The usefulness of both approaches has been verified experimentally on publicly available clinical trial data.
Revisiting Trace and Testing Equivalences for Nondeterministic and Probabilistic Processes

One of the most studied extensions of testing theory to nondeterministic and probabilistic processes yields unrealistic probabilities estimations that give rise to two anomalies. First, probabilistic testing equivalence does not imply probabilistic trace equivalence. Second, probabilistic testing equivalence differentiates processes that perform the same sequence of actions with the same probability but make internal choices in different moments and thus, when applied to processes without probabilities, does not coincide with classical testing equivalence. In this paper, new versions of probabilistic trace and testing equivalences are presented for nondeterministic and probabilistic processes that resolve the two anomalies. Instead of focussing only on suprema and infima of the set of success probabilities of resolutions of interaction systems, our testing equivalence matches all the resolutions on the basis of the success probabilities of their identically labeled computations. A simple spectrum is provided to relate the new relations with existing ones. It is also shown that, with our approach, the standard probabilistic testing equivalences for generative and reactive probabilistic processes can be retrieved.
Reseacrh of Police’s Mental Heatlh and Influence Factors in Badly Damaged Regions One Year After Earthquake

Objective: To explore and analyze post-earthquake police’s mental health and the influence factors in the badly damaged regions one year after the earthquake. Methods: Symptom Checklist 90 (SCL-90) was administered to 1000 police in Mianyang city. Results: The overall level of Mianyang police’s mental health after the earthquake was significantly lower than that of the national ordinary population excluding interpersonal sensitivity dimensions; The differences of police’s mental health among different types of police were significant,Community police and traffic police’s mental health was significantly lower than the other types of police; The factors of gender, age, time of participating in police work and the level of education had no influence on mental health. Conclusion: The police’s mental health is significantly lower than that of the national ordinary population in the regions badly damaged by earthquake; The influence of police type is a major factor in mental health.
Culture, spirituality, religion and health: looking at the big picture

Religion provides things that are good for health and wellbeing, including social support, existential meaning, a sense of purpose, a coherent belief system and a clear moral code. But these benefits can also come from other sources. Conversely, religion is shaped by its social context in ways that affect its social role. Religion is no panacea when it comes to improving health. Religion's role in health needs to be examined in a broad context, especially the ways in which culture influences religion's expression of the spiritual.
Soil warming in a cool-temperate mixed forest with peat soil enhanced heterotrophic and basal respiration rates but Q 10 remained unchanged

Abstract. We conducted soil warming experiment in a cool-temperate forest with peat soil in northern Japan, during the snowless seasons of 2007–2009. Our objective was to determine whether or not the heterotrophic respiration rate and the temperature sensitivity would change by soil warming. We elevated the soil temperature by 3 °C at 5 cm depth by means of overhead infrared heaters and continuously measured soil CO2 fluxes by using a fifteen-channel automated chamber system. Trenching treatment was also carried out to separate heterotrophic respiration and root respiration from the total soil respiration. The fifteen chambers were divided into three groups each with five replications for the control, unwarmed-trenched, and warmed-trenched treatments. We found that heterotrophic respiration contributed 71 % of the total soil respiration with the remaining 29 % accounted to autotrophic respiration. Soil warming enhanced heterotrophic respiration by 74 % (mean 6.11 ± 3.07 S.D. μmol m−2 s–1) as compared to the unwarmed-trenched treatment (mean 3.52 ± 1.74 μmol m−2 s–1). Soil CO2 efflux, however, was weakly correlated with soil moisture, probably because the volumetric soil moisture (33–46 %) was within a plateau region for root and microbial activities. The enhancement in heterotrophic respiration with soil warming in our study suggests that global warming will accelerate the loss of carbon from forested peatlands more seriously than other upland forest soils. On the other hand, soil warming did not cause significant change in the temperature sensitivity, Q10, (2.79 and 2.74 determined using hourly efflux data for unwarmed- and warmed-trenched, respectively), but increased their basal respiration rate at 0 °C (0.93 and 1.21 μmol m−2 s−1, respectively). Results suggest that if we predict the soil heterotrophic respiration rate in future warmer environment using the current relationship between soil temperature and heterotrophic respiration, the rate can be underestimated.
HIF- and Non-HIF-Regulated Hypoxic Responses Require the Estrogen-Related Receptor in Drosophila melanogaster

Low-oxygen tolerance is supported by an adaptive response that includes a coordinate shift in metabolism and the activation of a transcriptional program that is driven by the hypoxia-inducible factor (HIF) pathway. The precise contribution of HIF-1a in the adaptive response, however, has not been determined. Here, we investigate how HIF influences hypoxic adaptation throughout Drosophila melanogaster development. We find that hypoxic-induced transcriptional changes are comprised of HIF-dependent and HIF-independent pathways that are distinct and separable. We show that normoxic set-points of carbohydrate metabolites are significantly altered in sima mutants and that these animals are unable to mobilize glycogen in hypoxia. Furthermore, we find that the estrogen-related receptor (dERR), which is a global regulator of aerobic glycolysis in larvae, is required for a competent hypoxic response. dERR binds to dHIFa and participates in the HIF-dependent transcriptional program in hypoxia. In addition, dERR acts in the absence of dHIFa in hypoxia and a significant portion of HIF-independent transcriptional responses can be attributed to dERR actions, including upregulation of glycolytic transcripts. These results indicate that competent hypoxic responses arise from complex interactions between HIF-dependent and -independent mechanisms, and that dERR plays a central role in both of these programs.
LEVERAGE AND THE WEALTH GAINS FROM ACQUISITION PROGRAM ANNOUNCEMENTS

We examine the market reaction to announcements of an intention to pursue a program of external acquisitions. Although the mean gain is positive, only firms with high Tobin's q and low leverage experience significant abnormal returns. For firms with low q or high leverage, abnormal returns are zero. Moreover, the stock price reaction is an increasing function of q only for firms with low leverage. These results are consistent with the view that high leverage reduces the ability of a firm to take full advantage of profitable investment opportunities.
The moderating effect of place attachment on the relationship between festival quality and behavioral intentions

ABSTRACT The main purpose of the study is to examine an impact of festival quality on behavioral intentions and investigate the role of place attachment (PA) as a moderator between festival quality and behavioral intentions. Data were collected from the visitors of the 2013 Seoul Lantern Festival in South Korea. Results show that festival quality has a significant direct impact on behavioral intentions to revisit, spread word of mouth (WOM), and engage in pro-environmental behavior. The study also reveals that PA moderates the effect of festival quality on behavioral intentions, suggesting the differential impact of festival quality based on the level of PA. The study suggests that festival organizers may want to focus on program and esthetics to promote visitors’ return and positive WOM. Festival organizers may also want to customize quality management strategies based on visitors’ level of PA.
Analysis of Doctoral Thesis Citation Patterns: A Case Study of the Sam Jonah Library, Ghana

The use of bibliometrics as an essential tool for collection development is well acknowledged by many researchers because it employs quantitative methods when seeking to measure and assess the output of scientific publications. A quantitative evaluation of publications and citations can be beneficial for effective collection development. The purpose of this study was to conduct an in-depth analysis of the citation patterns in the PhD dissertations submitted to the Graduate School of the University of Cape Coast between 2005 and 2016. A total of 35 PhD theses were submitted within this time period and were obtained from the Africana section of the Sam Jonah Library. The reference section from each thesis was photocopied and manually examined. Overall, 6,458 citations were analysed. Journal articles were the most cited publications, followed by books, reports and web resources. The findings also showed that a majority (73.3%) of the journals cited by PhD students could be accessed through Sam Jonah Library’s subscribed online databases. The study concludes that although the use of these databases is high among PhD students, there is a need for greater awareness and training in the use of these databases.
Tracking the Dynamics in Crowdfunding

Crowdfunding is an emerging Internet fundraising mechanism by raising monetary contributions from the crowd for projects or ventures. In these platforms, the dynamics, i.e., daily funding amount on campaigns and perks (backing options with rewards), are the most concerned issue for creators, backers and platforms. However, tracking the dynamics in crowdfunding is very challenging and still under-explored. To that end, in this paper, we present a focused study on this important problem. A special goal is to forecast the funding amount for a given campaign and its perks in the future days. Specifically, we formalize the dynamics in crowdfunding as a hierarchical time series, i.e., campaign level and perk level. Specific to each level, we develop a special regression by modeling the decision making process of the crowd (visitors and backing probability) and exploring various factors that impact the decision; on this basis, an enhanced switching regression is proposed at each level to address the heterogeneity of funding sequences. Further, we employ a revision matrix to combine the two-level base forecasts for the final forecasting. We conduct extensive experiments on a real-world crowdfunding data collected from Indiegogo.com. The experimental results clearly demonstrate the effectiveness of our approaches on tracking the dynamics in crowdfunding.
Influence of the tyre impedance on CPX level used to evaluate tyre/road noise

For traffic noise studies CPX measurements are used to evaluate the noise-reduction of a road surface.CPX measurements as described in ISO/DIS 11819-2 are carried out at microphone positions close to predefined tyres at constant speed. The dominant CPX sound source is the tyre’s rolling noise as a result of tyre/road interaction, which - apart from the acoustic properties of the road surface - is mainly determined by the properties of the tyre.To ensure continuous quality and comparability of CPX measurements, the variation of acoustically relevant properties of the reference tyres must be taken into account to reduce measurement uncertainties. Thus, to ensure comparability, the standard ISO/TS 11819-3 specifies Shore hardness values to be checked at regular intervals and compared with normative values. According to our experience in CPX-measurements, determining the Shore hardness of the tyres is not sufficient to describe the reference tyres’ acoustically relevant properties. So, as an additional parameter the mechanical impedance of different reference tyres was measured and compared to their Shore hardness and CPX levels on different road surfaces.Based on these results, conclusions are drawn about the usability of the tyre impedance to increase the quality and comparability of CPX measurements.
Enhancement of red blood cell transfusion compatibility using CRISPR‐mediated erythroblast gene editing

Regular blood transfusion is the cornerstone of care for patients with red blood cell (RBC) disorders such as thalassaemia or sickle‐cell disease. With repeated transfusion, alloimmunisation often occurs due to incompatibility at the level of minor blood group antigens. We use CRISPR‐mediated genome editing of an immortalised human erythroblast cell line (BEL‐A) to generate multiple enucleation competent cell lines deficient in individual blood groups. Edits are combined to generate a single cell line deficient in multiple antigens responsible for the most common transfusion incompatibilities: ABO (Bombay phenotype), Rh (Rhnull), Kell (K0), Duffy (Fynull), GPB (S−s−U−). These cells can be differentiated to generate deformable reticulocytes, illustrating the capacity for coexistence of multiple rare blood group antigen null phenotypes. This study provides the first proof‐of‐principle demonstration of combinatorial CRISPR‐mediated blood group gene editing to generate customisable or multi‐compatible RBCs for diagnostic reagents or recipients with complicated matching requirements.
Variation in reproductive success across captive populations: Methodological differences, potential biases and opportunities

Our understanding of fundamental organismal biology has been disproportionately influenced by studies of a relatively small number of ‘model’ species extensively studied in captivity. Laboratory populations of model species are commonly subject to a number of forms of past and current selection that may affect experimental outcomes. Here, we examine these processes and their outcomes in one of the most widely used vertebrate species in the laboratory – the zebra finch (Taeniopygia guttata). This important model species is used for research across a broad range of fields, partly due to the ease with which it can be bred in captivity. However despite this perceived amenability, we demonstrate extensive variation in the success with which different laboratories and studies bred their subjects, and overall only 64% of all females that were given the opportunity, bred successfully in the laboratory. We identify and review several environmental, husbandry, life-history and behavioural factors that potentially contribute to this variation. The variation in reproductive success across individuals could lead to biases in experimental outcomes and drive some of the heterogeneity in research outcomes across studies. The zebra finch remains an excellent captive animal system and our aim is to sharpen the insight that future studies of this species can provide, both to our understanding of this species and also with respect to the reproduction of captive animals more widely. We hope to improve systematic reporting methods and that further investigation of the issues we raise will lead both to advances in our fundamental understanding of avian reproduction as well as to improvements in future welfare and experimental efficiency.
The Personal Characteristics and Environmental Circumstances of Successful Women Musicians

This study investigated the personal characteristics and environmental circumstances of successful U.S. and European women in music and compared these findings with 14 specific characteristics from previous research on eminent people and high-achieving adolescent girls. Data were gathered through a survey questionnaire completed by 60 professional musicians and 61 trained female musicians who decided against a career in music, and 12 interviews of professional women musicians. Results indicated that both groups surveyed appeared to have many of the characteristics of other eminent and high-achieving people. Differences in personal characteristics suggested that professional musicians are highly self-directed, motivated, less conforming to gender stereotypes, and aware of a career goal at an early age. Differences in environmental circumstances suggested that professional musicians come from highly musical families and may come from homes either without brothers or with much younger brothers.
Isoleucine starvation caused by sulfometuron methyl in Salmonella typhimurium measured by translational frameshifting.

The authors have developed a tool for the study of inhibitor-induced amino acid starvation in bacteria which exploits the phenomenon of translational frameshifting. The inhibition of acetohydroxyacid synthase II by the herbicide sulfometuron methyl (SMM) has complex effects on branched-chain amino acid biosynthesis. Experiments were done with Salmonella typhimurium containing a plasmid with an isoleucine codon in a 'shifty' region, prone to translational frameshifting. SMM did not cause translational frameshifting in minimal medium under conditions that inhibit growth. A 20-fold higher concentration of SMM was required to cause starvation for isoleucine, e.g. in the presence of valine. This starvation was reflected in translational frameshifting correlated with inhibition of growth. These observations support the authors' previous suggestions based on other techniques. The method used here could be generalized for the study of complex metabolic effects related to amino acids.