Miracle-dz/UniFAR-FTUs huggingface dataset:
Universities-Industry Collaboration: A Systematic Review

The collaboration between universities and the industry is increasingly perceived as a vehicle to enhance innovation through knowledge exchange. This is evident by a significant increase in studies that investigate the topic from different perspectives. However, this body of knowledge is still described as fragmented and lacks efficient comprehensive view. To address this gap, we employed a systematic procedure to review the literature on universities–industry collaboration (UIC). The review resulted in identifying five key aspects, which underpinned the theory of UIC. We integrate these key aspects into an overarching process framework, which together with the review, provide a substantial contribution by creating an integrated analysis of the state of literature concerning this phenomenon. Several research avenues are reported as distilled from the analysis.
Mechanism Regulating Reactive Oxygen Species in Tumor-Induced Myeloid-Derived Suppressor Cells1

Myeloid-derived suppressor cells (MDSC) are a major component of the immune suppressive network described in cancer and many other pathological conditions. Recent studies have demonstrated that one of the major mechanisms of MDSC-induced immune suppression is mediated by reactive oxygen species (ROS). However, the mechanism of this phenomenon remained unknown. In this study, we observed a substantial up-regulation of ROS by MDSC in all of seven different tumor models and in patients with head and neck cancer. The increased ROS production by MDSC is mediated by up-regulated activity of NADPH oxidase (NOX2). MDSC from tumor-bearing mice had significantly higher expression of NOX2 subunits, primarily p47phox and gp91phox, compared with immature myeloid cells from tumor-free mice. Expression of NOX2 subunits in MDSC was controlled by the STAT3 transcription factor. In the absence of NOX2 activity, MDSC lost the ability to suppress T cell responses and quickly differentiated into mature macrophages and dendritic cells. These findings expand our fundamental understanding of the biology of MDSC and may also open new opportunities for therapeutic regulation of these cells in cancer.
A time series analysis of the effects of financial incentives and mandatory clinical applications as interventions to improve spontaneous adverse drug reaction reporting by hospital medical staff in China

RATIONALE, AIMS, AND OBJECTIVES Spontaneous reporting of adverse drug reactions (ADRs) in hospitals is often under-reported, which may lead to problems in patient management. This study was aimed to assess the effectiveness of a financial intervention based on a fine and a bonus for improving spontaneous reporting of ADRs by physicians in a hospital setting. METHODS This study was conducted at the First Affiliated Hospital of Zhengzhou University (China). Starting in 2009, a bonus of 20 RMB (Chinese currency) was given for each spontaneous ADR report, and a fine of 50 RMB was given for any withheld ADR report. A time series analysis using autoregressive integrated moving average models was performed to assess the changes in the total number of spontaneous ADR reports between the preintervention period (2006-2008) and during the first (2009-2011) and second (2012-2014) intervention periods. RESULTS The median number of reported ADRs per year increased from 29 (range 27-72) in the preintervention period to 277 (range 199-284) in the first intervention period and to 666 in the second (range 644-691). The monthly number of reported ADRs was stable during the 3 periods: 3.56 ± 3.60/month (95% confidence interval (CI), 2.42-4.75) during the preintervention period, 21 ± 13/month (95% CI, 16.97-25.80) in the first intervention period, and 56 ± 20/month (95% CI, 48.81-62.17) in the second intervention period. CONCLUSION A financial incentive and ADR management regulations had a significant effect on the increase of reported ADRs.
Dorsomedial and dorsolateral striatum exhibit distinct phasic neuronal activity during alcohol self‐administration in rats

The development of alcoholism may involve a shift from goal‐directed to habitual drinking. These action control systems are distinct in the dorsal striatum, with the dorsomedial striatum (DMS) important for goal‐directed behavior and the dorsolateral striatum (DLS) required for habit formation. Goal‐directed behavior can be modeled in rats with a fixed ratio (FR) reinforcement schedule, while a variable interval (VI) schedule promotes habitual behavior (e.g. insensitivity to contingency degradation). Using extracellular recordings from chronically implanted electrodes, we investigated how DMS and DLS neurons encoded lever‐press responses and conditioned cues during operant alcohol self‐administration in these two models. In rats self‐administering 10% alcohol on an FR schedule, the DMS neuronal population showed increased firing at the onset of start‐of‐session stimuli. During self‐administration, the most prominent phasic firing patterns in the DMS occurred at the time of reinforcement and reinforcement‐associated cues, while the most prominent phasic activity in the DLS surrounded the lever response. Neural recordings from an additional cohort of rats trained on a VI schedule revealed a similar pattern of results; however, phasic changes in firing were smaller and differences between the medial and lateral dorsal striatum were less marked. In summary, the DMS and DLS exhibited overlapping but specialized phasic firing patterns: DMS excitations were typically time‐locked to reinforcement, while DLS excitations were generally associated with lever responses. Furthermore, the regional specificities and magnitudes of phasic firing differed between reinforcement schedules, which may reflect differences in behavioral flexibility, reward expectancy and the action sequences required to procure reinforcement.
RASA1 Mutations and Associated Phenotypes in 68 Families with Capillary Malformation–Arteriovenous Malformation

Capillary malformation–arteriovenous malformation (CM–AVM) is an autosomal‐dominant disorder, caused by heterozygous RASA1 mutations, and manifesting multifocal CMs and high risk for fast‐flow lesions. A limited number of patients have been reported, raising the question of the phenotypic borders. We identified new patients with a clinical diagnosis of CM–AVM, and patients with overlapping phenotypes. RASA1 was screened in 261 index patients with: CM–AVM (n = 100), common CM(s) (port‐wine stain; n = 100), Sturge–Weber syndrome (n = 37), or isolated AVM(s) (n = 24). Fifty‐eight distinct RASA1 mutations (43 novel) were identified in 68 index patients with CM–AVM and none in patients with other phenotypes. A novel clinical feature was identified: cutaneous zones of numerous small white pale halos with a central red spot. An additional question addressed in this study was the “second‐hit” hypothesis as a pathophysiological mechanism for CM–AVM. One tissue from a patient with a germline RASA1 mutation was available. The analysis of the tissue showed loss of the wild‐type RASA1 allele. In conclusion, mutations in RASA1 underscore the specific CM–AVM phenotype and the clinical diagnosis is based on identifying the characteristic CMs. The high incidence of fast‐flow lesions warrants careful clinical and radiologic examination, and regular follow‐up.
American Society of Anesthesiologists Score: still useful after 60 years? Results of the EuSOS Study

Objective The European Surgical Outcomes Study described mortality following in-patient surgery. Several factors were identified that were able to predict poor outcomes in a multivariate analysis. These included age, procedure urgency, severity and type and the American Association of Anaesthesia score. This study describes in greater detail the relationship between the American Association of Anaesthesia score and postoperative mortality. Methods Patients in this 7-day cohort study were enrolled in April 2011. Consecutive patients aged 16 years and older undergoing inpatient non-cardiac surgery with a recorded American Association of Anaesthesia score in 498 hospitals across 28 European nations were included and followed up for a maximum of 60 days. The primary endpoint was in-hospital mortality. Decision tree analysis with the CHAID (SPSS) system was used to delineate nodes associated with mortality. Results The study enrolled 46,539 patients. Due to missing values, 873 patients were excluded, resulting in the analysis of 45,666 patients. Increasing American Association of Anaesthesia scores were associated with increased admission rates to intensive care and higher mortality rates. Despite a progressive relationship with mortality, discrimination was poor, with an area under the ROC curve of 0.658 (95% CI 0.642 - 0.6775). Using regression trees (CHAID), we identified four discrete American Association of Anaesthesia nodes associated with mortality, with American Association of Anaesthesia 1 and American Association of Anaesthesia 2 compressed into the same node. Conclusion The American Association of Anaesthesia score can be used to determine higher risk groups of surgical patients, but clinicians cannot use the score to discriminate between grades 1 and 2. Overall, the discriminatory power of the model was less than acceptable for widespread use.
Does abscisic acid affect strigolactone biosynthesis?

SUMMARY *Strigolactones are considered a novel class of plant hormones that, in addition to their endogenous signalling function, are exuded into the rhizosphere acting as a signal to stimulate hyphal branching of arbuscular mycorrhizal (AM) fungi and germination of root parasitic plant seeds. Considering the importance of the strigolactones and their biosynthetic origin (from carotenoids), we investigated the relationship with the plant hormone abscisic acid (ABA). *Strigolactone production and ABA content in the presence of specific inhibitors of oxidative carotenoid cleavage enzymes and in several tomato ABA-deficient mutants were analysed by LC-MS/MS. In addition, the expression of two genes involved in strigolactone biosynthesis was studied. *The carotenoid cleavage dioxygenase (CCD) inhibitor D2 reduced strigolactone but not ABA content of roots. However, in abamineSG-treated plants, an inhibitor of 9-cis-epoxycarotenoid dioxygenase (NCED), and the ABA mutants notabilis, sitiens and flacca, ABA and strigolactones were greatly reduced. The reduction in strigolactone production correlated with the downregulation of LeCCD7 and LeCCD8 genes in all three mutants. *The results show a correlation between ABA levels and strigolactone production, and suggest a role for ABA in the regulation of strigolactone biosynthesis.
Simulating psychophysical tuning curves in listeners with dead regions

Abstract Objective: This study investigates the relation between diagnosis of dead regions based on the off-frequency psychophysical tuning curve (PTC) tip and the frequency and level of the probe tone. Design: A previously developed functional model of auditory processing was used to simulate the complete loss of inner hair cells (IHC), dysfunction of outer hair cells (OHC), complete loss of IHCs in combination with OHC dysfunction, and IHC insensitivity. The model predictions were verified through comparison with experimental data. Study sample: This study compares PTC data of five normal-hearing listeners and six hearing-impaired listeners with model-simulated PTC data. Results: It was shown that OHC activity and IHC insensitivity may significantly alter the shift of PTC tips with increasing probe level. Conclusions: Model results suggest that OHC activity and IHC insensitivity can change the outcome of dead region diagnosis using PTCs. Supplementary to PTC dead region diagnostic information, model results may provide additional information regarding the edge frequency of a dead region and OHC function.
DIIORIO HPA BIOLOGICALLY-INFORMED MULTILOCUS PROFILE

Word Count: 252 Introduction Word Count: 575/1000 Discussion Word Count: 1688/2000 Total Word Count: 4758/6000 Tables/Figures: 6/6 Number of References: 76/50 Date of Submission: 10/07/2016 Date of Resubmission: 01/03/2017 Hypothalamic-Pituitary-Adrenal Axis Genetic Variation and Early Stress Moderates Amygdala Function Christina R. Di Iorio, Caitlin E. Carey, 1 Lindsay J Michalski, Nadia S. Corral-Frias, 2 Emily Drabant Conley, Ahmad R. Hariri, Ryan Bogdan BRAIN Lab, Department of Psychology, Washington University in St. Louis, St. Louis, MO, USA 2 Department of Psychiatry, Washington University in St. Louis, St. Louis, MO, USA 3 23andMe Department of Psychology and Neuroscience, Duke University, Durham, NC, USA Neurosciences Program, Division of Biology and Biomedical Sciences, Washington University in St. Louis, St. Louis, MO, USA Molecular Genetics and Genomics Program, Division of Biology and Biomedical Sciences, Washington University in St. Louis, St. Louis, MO, USA Human and Statistical Genetics Program, Division of Biology and Biomedical Sciences, Washington University in St. Louis, St. Louis, MO, USA Corresponding authors: Christina Di Iorio & Ryan Bogdan WUSTL, Psych Bldg, CB 1125 One Brookings Drive St. Louis, MO 63130 Phone: 617-407-5645; email: crdiiorio@wustl.edu, rbogdan@wustl.edu, Highlights  HPA axis genetic profile and early life stress interact to predict amygdala function  HPA axis genetic profile is associated with anxiety symptoms  Within system genetic profiles may inform our understanding of psychopathology DIIORIO HPA BIOLOGICALLY-INFORMED MULTILOCUS PROFILE 2
Ceftizoxime interpretive criteria for in vitro susceptibility tests with Neisseria gonorrhoeae

Ceftizoxime was tested in triplicate against 100 clinical strains of Neisseria gonorrhoeae in accordance with National Committee for Clinical Laboratory Standards guidelines to establish susceptibility testing interpretive criteria. The MICs for 50 and 90% of the strains tested were 0.008 and 0.03 microgram/ml, respectively. These results confirm those of other studies reporting ceftizoxime's excellent activity against gonococci. Because no resistant strains were identified, a breakpoint MIC of < or = 0.5 microgram/ml was selected, with a correlate zone diameter of > or = 32 mm. Ceftizoxime appears to represent an alternative to other beta-lactamase-stable beta-lactams for cost-effective therapy of uncomplicated gonorrhea.
Employee Thoughts on Influenza Vaccine: Here We Go Again

Author(s): Noreen H. Chan‐Tompkins , PharmD; Andrew Sahud , MD; Deborah Pucci , RN, BSN, CCM; Cheryl Herbert , RN, CIC Source: Infection Control and Hospital Epidemiology, Vol. 29, No. 2 (February 2008), pp. 186187 Published by: The University of Chicago Press on behalf of The Society for Healthcare Epidemiology of America Stable URL: http://www.jstor. org/stable/10.1086/524913 . Accessed: 16/05/2014 04:48
Unpacking the Meaning of “Market Access”

Improving farmers’ access to markets is widely recognized as a major development challenge. A review of the literature suggests that indicators of market access may bear little relationship to the specific processes of interest and hence provide misguided evidence of the impacts of improved market access. This paper attempts to “unpack” the dimensions of market access and, in the process, uses farm survey data from Kenya to investigate changes in multiple indicators during the post-liberalization period. Findings show that market access conditions experienced by rural Kenyans exhibit considerable variation across time, space, and indicator type. We suggest ways in which structured hypothesizing and sensitivity analysis may strengthen empirical treatments of market access issues in applied research.
A new strict Lyapunov function for fully-actuated mechanical systems controlled by IDA-PBC

In this brief note a new strict Lyapunov function for mechanical systems controlled by the well-known Passivity-based Control technique of Interconnection and Damping Assignment is proposed. The general, total energy-shaping, formulation of the control technique is considered, which yields a port-Hamiltonian closed-loop system with non-fixed symplectic structure. To construct the proposed Lyapunov function a new systematic mathematical machinery is introduced. The resulting Lyapunov function contains, as particular cases, previous functions obtained for robot manipulators controlled by potential energy-shaping (plus damping injection) schemes. An additional contribution of our work is that, in contrast with most of the existing literature on this topic that is restricted to robot manipulators with only revolute joints, our analysis is applicable to robots with both revolute and prismatic joints. As an illustration example, practical bounds for a two-link direct drive robot manipulator are computed.
Throughput-delay trade-off for hierarchical cooperation in ad hoc wireless networks

Hierarchical cooperation has recently been shown to achieve better throughput scaling than classical multihop schemes in static wireless networks. However, the end-to-end delay of this scheme turns out to be significantly larger than those of multihop schemes. A modification of the scheme is proposed here that achieves a throughput-delay trade-off D(n) = (logn)2T(n) for T(n) between thetas(radicn/ log n) and thetas(n/ log n), where D(n) and T(n) are respectively the average delay per bit and the aggregate throughput in a network of n nodes. This trade-off complements the previous results, which show that the throughput-delay trade-off for multihop schemes is given by D(n) = T(n) where T(n) lies between thetas(1) and thetas(radicn).
Are positive learning experiences levers for lifelong learning among low educated workers

Purpose - – Based on the theory of planned behaviour and social learning theory, the purpose of this paper is to investigate the effect of training participation and learning experience on the beliefs of low-educated employees about their self-efficacy for learning. Design/methodology/approach - – Low-educated workers of three different organizations ( Findings - – Training participation alone did not affect low-educated workers’ learning self-efficacy, but a positive learning experience did contribute to workers’ post-training learning self-efficacy. These results support the relevance of positive learning experiences. Research limitations/implications - – Follow-up studies could focus on the effects of learning self-efficacy for subsequent learning activities, establish which aspects of training contribute to a positive learning experience, and include contextual characteristics that may predict learning self-efficacy. Practical implications - – To stimulate learning among lower educated workers, it is necessary that they have confidence in their ability to successfully complete their training. Trainers and training developers working for this specific target group of lower educated workers should aim to provide training that is a positive experience, besides being a learning exercise. Originality/value - – The study is the first to analyse the longitudinal effects of training participation and learning experience on post-training learning self-efficacy among low-educated workers.
The 2 × 2 Model of Perfectionism and School--And Community-Based Sport Participation.

The authors adopted the 2 × 2 model of perfectionism to examine the unique and interactive effects of two dimensions of perfectionism (personal standards perfectionism PSP and evaluative concerns perfectionism ECP) on personal and interpersonal indicators of participant experience in youth sport (enjoyment, physical self‐worth, and friendship quality). Participants (N = 219, M age = 15.12, SD = 2.02) were recruited from various school‐ and community‐based sports and completed a multi‐section questionnaire. Consideration of main and interaction effects indicated that pure PSP (high PSP/low ECP) was associated with the most positive sport experience and pure ECP (low PSP/high ECP) was associated with the least positive sport experience. The findings suggest that subtypes of perfectionism from the 2 × 2 model are predictive of differing experiences in youth sport participation. (PsycINFO Database Record (c) 2015 APA, all rights reserved). (journal abstract)
Antiplatelet therapy discontinuation following drug‐eluting stent placement: Dangers, reasons, and management recommendations

Drug‐eluting stents (DES) have several advantages over bare‐metal stents (BMS), including significantly lower target vessel revascularization. However, DES is associated with a higher incidence of late stent thrombosis (ST). Although late ST after DES placement is uncommon (∼0.4–0.6%/year), it is catastrophic clinical consequences make it a concern. Dual antiplatelet therapy (DAT) with aspirin and clopidogrel is the standard of care for prevention of ST, and DAT discontinuation is associated with a marked increase in ST risk. These guidelines recommend continuing DAT for ≥12 months after DES implantation in patients not at high risk for bleeding. Premature DAT discontinuation is common in clinical practice. Therefore, it is imperative that physicians be aware of factors contributing to discontinuation, including cost, patient education, and actual bleeding events, so as to educate their patients about the risks and benefits of continued DAT. This review highlights the risks of premature DAT discontinuation, discusses common reasons for discontinuation, and offers potential solutions to improve adherence. © 2009 Wiley‐Liss, Inc.
Contribution of dppA to Urease Activity in Helicobacter pylori 26695

Background. The gastric pathogen Helicobacter pylori produces urease in amounts up to 10% of its cell protein. This enzyme, which catalyzes the hydrolysis of urea to ammonia and carbon dioxide, protects the bacterium from gastric acid. Urease, a nickel metalloenzyme, requires active uptake of nickel ions from the environment to maintain its activity. NixA is a nickel transport protein that resides in the cytoplasmic membrane. Mutation of nixA significantly reduces but does not abolish urease activity, strongly suggesting the presence of a second transporter. We postulated that the dipeptide permease (dpp) genes that are homologous to the nik operon of Escherichia coli could be a second nickel transporter. The predicted Dpp polypeptides DppA, DppC, and DppD of H. pylori share approximately 40%, 53%, and 56% amino acid sequence identity with their respective E. coli homologs.