Miracle-dz/UniFAR-FTUs huggingface dataset:
Genetic deletion of TNFR2 augments inflammatory response and blunts satellite‐cell‐mediated recovery response in a hind limb ischemia model

We have previously shown that TNF‐tumor necrosis factor receptor‐2/p75 (TNFR2/p75) signaling plays a critical role in ischemia‐induced neovascularization in skeletal muscle and heart tissues. To determine the role of TNF‐TNFR2/p75 signaling in ischemia‐induced inflammation and muscle regeneration, we subjected wild‐type (WT) and TNFR2/p75 knockout (p75KO) mice to hind limb ischemia (HLI) surgery. Ischemia induced significant and long‐lasting inflammation associated with considerable decrease in satellite‐cell activation in p75KO muscle tissue up to 10 d after HLI surgery. To determine the possible additive negative roles of tissue aging and the absence of TNFR2/p75, either in the tissue or in the bone marrow (BM), we generated 2 chimeric BM transplantation (BMT) models where both young green fluorescent protein (GFP)‐positive p75KO and WT BM‐derived cells were transplanted into adult p75KO mice. HLI surgery was performed 1 mo after BMT, after confirming complete engraftment of the recipient BM with GFP donor cells. In adult p75KO with the WT‐BMT, proliferative (Ki67+) cells were detected only by d 28 and were exclusively GFP+, suggesting significantly delayed contribution of young WT‐BM cell to adult p75KO ischemic tissue recovery. No GFP+ young p75KO BM cells survived in adult p75KO tissue, signifying the additive negative roles of tissue aging combined with decreased/absent TNFR2/p75 signaling in postischemic recovery. —Sasi, S. P., Rahimi, L. , Yan, X. , Silver, M. , Qin, G. , Losordo, D. W. , Kishore, R. , Goukassian, D. A. Genetic deletion of TNFR2 augments inflammatory response and blunts satellite‐cell‐mediated recovery response in a hind limb ischemia model. FASEB J. 29, 1208‐1219 (2015). www.fasebj. org
Activity Concentrations and Dose Assessment of Gamma Emitting Radionuclides in Canned Tuna and Sardines Produced after the Fukushima Nuclear Accident

AbstractThe aim of the present work was to investigate the radioactivity concentrations of gamma emitting radionuclides in canned tuna and sardines that were produced after the Fukushima nuclear accident and to assess the resulting radiation doses to the public. Fifty-eight brands of canned tuna and sardines consumed in the Middle East and produced from different parts of the world were analyzed using a germanium detector. Cesium-137 (137Cs) was not detected above the minimum detectable activity in any of the samples. Natural radionuclides 40K, 226Ra and 228Ra were detected with wide activity concentration ranges and with average values of (in Bq kg−1 wet weight): 68 ± 36, 0.31 ± 0.45, 0.34 ± 0.25, respectively, in tuna samples and with averages of 129 ± 67, 0.20 ± 0.33, 0.60 ± 0.31 in sardine samples. The results of the activity concentrations of 40K and 226Ra showed some regional dependence. Tuna samples produced in Europe have almost twice the concentration of 40K and half the concentration of 226Ra as compared to samples produced in either East or South Asia and North America. Moreover, sardine samples produced in North Africa and Europe have almost twice the concentrations of 40K and 226Ra as those produced in East or South Asia and North America. Dose assessment due to ingestion of canned seafood was also performed, and the committed effective dose was found to be well within the worldwide average.
Dietary roller milled sorghum improves broiler efficiency and whole sorghum improves gut development

Summary The effects of particle size and type of milling of dietary sorghum for broilers were examined. Sorghum treatments were: whole (WS), hammer–milled with a 3 mm screen (HM3), roller–milled with 0.15 mm roller spacing (RM0.15) and hammer–milled with a 1 mm screen (HM1). Diets HM3 and RM0.15 were milled to the same particle size. All diets were pelleted. Birds fed RM0.15 were more efficient than those fed the other treatments at 21 and 35 days of age (d), but there was no effect on cumulative feed intake and bodyweight at 35 d. At 35 d, there was no particle size effect of hammer– milled sorghum on performance; birds fed WS were least efficient. Nitrogen–corrected apparent metabolisable energy (AME n ) was increased by whole sorghum relative to that of processed sorghum. Relative gizzard weight was proportional to pre–pellet particle size at 21 d and was decreased by HM1 relative to the other treatments at 35 d. Relative proventriculus weight was increased by HM1 at 21 d and 35 d. Neither particle size nor processing type affected relative weights of intestinal segments. Digesta pH decreased in the gizzard and increased in the duodenum for WS relative to HM1. At 21 d, the surface area of duodenal digesta particles was smaller for WS and HM1 than for HM3 and RM0.15. At 35 d, the specific surface area of duodenal digesta particles was highest for WS. Feed conversion and gut development were improved by roller–milled sorghum. Whole sorghum improved gut development and AME n at the expense of performance.
Enterotoxin production in relation to taxonomic grouping and source of isolation of Aeromonas species

A total of 19 of 20 (95%) strains of Aeromonas hydrophila biovar hydrophila and 16 of 17 (94%) strains of Aeromonas sobria isolated from a variety of clinical and environmental sources were found to be enterotoxin positive. Only 2 of 18 (11%) A. hydrophila biovar anaerogenes and 2 of 13 (15%) unidentified Aeromonas strains from a similar variety of sources produced enterotoxin. No association was apparent between the source of isolation, in particular diarrheal stools, and enterotoxigenicity; 41% of the isolates from diarrheal stools were enterotoxin negative. A strong correlation was noted between ability to produce enterotoxin and positive results in six characters: lysine decarboxylase and Voges-Proskauer reactions, production of gas from glucose, gluconate oxidation, xanthine hydrolysis, and hemolysis of human erythrocytes. In the majority of cases (35 of 39 strains), enterotoxigenicity was detected using cell-free filtrates of brain heart infusion broth cultures grown at 36 degrees C for 15; however, the other four positive isolates were detected after growth in the same broth at 30 degrees C or in Casamino Acids-yeast extract broth at 30 or 37 degrees C. It is recommended that for enterotoxin tests, strains should be grown in both media at both temperatures. The infant mouse test was found to be a simple and reliable method for detection of the enterotoxin. The toxin proved to be heat labile and not neutralized by cholera antitoxin.
Parallel consensual neural networks

A neural network architecture is proposed and applied in classification of remote sensing/geographic data from multiple sources. The architecture is called the parallel consensual neural network, and its relation to hierarchical and ensemble neural networks is discussed. The parallel consensual neural network architecture is based on statistical consensus theory. The input data are transformed several times. The different transformed data are applied as if they were independent inputs, and are classified using stage neural networks. The outputs from the stage networks are weighted and combined to make a decision. Experimental results based on remote sensing data and geographic data are given. The performance of the consensual neural network architecture is compared to that of a two-layer (one hidden layer) conjugate-gradient backpropagation neural network. The results compare favorably in terms of classification accuracy to the backpropagation method. <<ETX>>
Arsenic Toxicology: Translating between Experimental Models and Human Pathology

Background: Chronic arsenic exposure is a worldwide health problem. How arsenic exposure promotes a variety of diseases is poorly understood, and specific relationships between experimental and human exposures are not established. We propose phenotypic anchoring as a means to unify experimental observations and disease outcomes. Objectives: We examined the use of phenotypic anchors to translate experimental data to human pathology and investigated research needs for which phenotypic anchors need to be developed. Methods: During a workshop, we discussed experimental systems investigating arsenic dose/exposure and phenotypic expression relationships and human disease responses to chronic arsenic exposure and identified knowledge gaps. In a literature review, we identified areas where data exist to support phenotypic anchoring of experimental results to pathologies from specific human exposures. Discussion: Disease outcome is likely dependent on cell-type–specific responses and interaction with individual genetics, other toxicants, and infectious agents. Potential phenotypic anchors include target tissue dosimetry, gene expression and epigenetic profiles, and tissue biomarkers. Conclusions: Translation to human populations requires more extensive profiling of human samples along with high-quality dosimetry. Anchoring results by gene expression and epigenetic profiling has great promise for data unification. Genetic predisposition of individuals affects disease outcome. Interactions with infectious agents, particularly viruses, may explain some species-specific differences between human pathologies and experimental animal pathologies. Invertebrate systems amenable to genetic manipulation offer potential for elaborating impacts of specific biochemical pathways. Anchoring experimental results to specific human exposures will accelerate understanding of mechanisms of arsenic-induced human disease.
An Investigation of the Variables Associated with Normal and Delayed Hospital Discharge following First Time Isolated Coronary Artery Bypass Graft Surgery

The optimum day for discharge after coronary artery bypass graft (CABG) surgery has been subject to some debate yet there has been a steady increase in the number of patients discharged within 5 days of surgery. Delayed discharges may result in the under use of surgical capacity and impact upon patient outcomes. The author conducted a retrospective; correlational study of 333 patients to investigate the variables associated with delayed discharge after CABG. The results suggest it is possible to identify patients likely to achieve a 5-day discharge from their age and Parsonnet score [Circulation, 79(Suppl. I), 1989, 3. ]. The introduction of a policy of adopting a 5-day discharge for those patients could maximise surgical capacity and improve patient outcomes. Further prospective study is recommended after the policy has been implemented to evaluate the effectiveness of age and Parsonnet score to predict a 5-day discharge.
Does Epileptiform Activity Represent a Failure of Neuromodulation to Control Central Pattern Generator-Like Neocortical Behavior?

Rhythmic motor patterns in invertebrates are often driven by specialized “central pattern generators” (CPGs), containing small numbers of neurons, which are likely to be “identifiable” in one individual compared with another. The dynamics of any particular CPG lies under the control of modulatory substances, amines, or peptides, entering the CPG from outside it, or released by internal constituent neurons; consequently, a particular CPG can generate a given rhythm at different frequencies and amplitudes, and perhaps even generate a repertoire of distinctive patterns. The mechanisms exploited by neuromodulators in this respect are manifold: Intrinsic conductances (e.g., calcium, potassium channels), conductance state of postsynaptic receptors, degree of plasticity, and magnitude and kinetics of transmitter release can all be affected. The CPG concept has been generalized to vertebrate motor pattern generating circuits (e.g., for locomotion), which may contain large numbers of neurons – a construct that is sensible, if there is enough redundancy: that is, the large number of neurons consists of only a small number of classes, and the cells within any one class act stereotypically. Here we suggest that CPG and modulator ideas may also help to understand cortical oscillations, normal ones, and particularly transition to epileptiform pathology. Furthermore, in the case illustrated, the mechanism of the transition appears to be an exaggerated form of a normal modulatory action used to influence sensory processing.
Neuropsychological Behavioral Inhibition System (BIS) and Behavioral Approach System (BAS) Assessment: A Shortened Sensitivity to Punishment and Sensitivity to Reward Questionnaire Version (SPSRQ–20)

This research was designed to investigate the items and factor structure of the Sensitivity to Punishment and Sensitivity to Reward Questionnaire (SPSRQ) proposed by Torrubia, Avila, Moltó, and Caseras (2001), as a measure of the behavioral inhibition system and behavioral activation system in Gray's reinforcement sensitivity theory. Recent studies that analyzed this instrument by exploratory and confirmatory factor analysis suggest the need for structural refinement. The Spanish version of the SPSRQ was analyzed by exploratory and confirmatory procedures in calibration (n = 2,102) and validation (n = 746) independent samples. In addition, convergent and discriminant validity was evaluated with the Zuckerman–Kuhlman Personality Questionnaire (Zuckerman, Kuhlman, Teta, Joireman, & Kraft, 1993), the Impulsiveness, Venturesomeness and Empathy Inventory (S. B. G. Eysenck, Pearson, Easting, & Allsopp, 1985) the Neuroticism, Extraversion and Openness Five Factor Inventory (Costa & McCrae, 1992), and the Barratt Impulsiveness Scales (Barratt, 1985). Results showed the robustness of a 20-item structure of the SPSRQ, with satisfactory fit adjustment, validity, and reliability. The findings are discussed in terms of the better functioning and sound psychometric properties of the SPSRQ 20-item version for Gray's personality theory.
Viewing Loved Faces Inhibits Defense Reactions: A Health-Promotion Mechanism?

We have known for decades that social support is associated with positive health outcomes. And yet, the neurophysiological mechanisms underlying this association remain poorly understood. The link between social support and positive health outcomes is likely to depend on the neurophysiological regulatory mechanisms underlying reward and defensive reactions. The present study examines the hypothesis that emotional social support (love) provides safety cues that activate the appetitive reward system and simultaneously inhibit defense reactions. Using the startle probe paradigm, 54 undergraduate students (24 men) viewed black and white photographs of loved (romantic partner, father, mother, and best friend), neutral (unknown), and unpleasant (mutilated) faces. Eye–blink startle, zygomatic major activity, heart rate, and skin conductance responses to the faces, together with subjective ratings of valence, arousal, and dominance, were obtained. Viewing loved faces induced a marked inhibition of the eye-blink startle response accompanied by a pattern of zygomatic, heart rate, skin conductance, and subjective changes indicative of an intense positive emotional response. Effects were similar for men and women, but the startle inhibition and the zygomatic response were larger in female participants. A comparison between the faces of the romantic partner and the parent who shares the partner’s gender further suggests that this effect is not attributable to familiarity or arousal. We conclude that this inhibitory capacity may contribute to the health benefits associated with social support.
Metabolic Abnormalities in Pain-Processing Regions of Patients with Fibromyalgia: A 3T MR Spectroscopy Study

As neuroradiologists we see many spine studies for fibromyalgia and wonder about the significance of this condition (is it a real disease? ). Here, the authors used MR spectroscopy to assess metabolic alterations in brain regions associated with pain reception (thalami and ventrolateral prefrontal cortex). Using 3T single-voxel MRS, they studied 12 patients and 12 healthy controls and analyzed their data using an LCModel. Glx/Cr and Glu/Cr ratios in the cortex were significantly higher in patients than in controls but no differences were found in the thalami. The authors conclude that these MRS abnormalities support an imbalance in the pain processing areas that underlie fibromyalgia. BACKGROUND AND PURPOSE: A growing body of evidence suggests the involvement of the brain in FM. The purpose of this proton MRS study was to test the hypothesis that there are metabolic alterations in some brain regions processing pain (VLPFC and thalamus) in patients with FM compared with HC. MATERIALS AND METHODS: Twelve patients with FM (30–54 years of age; mean age, 43.2 years), and 12 HC, matched for age and sex, underwent 1 session of single-voxel MRS performed on a 3T MR imaging scanner. MRS spectra were acquired with a PRESS for localization. The raw data from each spectrum was evaluated with an LCModel. T tests were used to evaluate differences of brain metabolites between groups. The Pearson correlation tested the relationship of metabolite ratios and clinical symptoms. RESULTS: Glx/Cr and Glu/Cr ratios within the VLPFC of both sides were significantly higher in patients than in HC (P < .01). No significant differences of metabolites between groups were found in the thalami. Positive correlations were found between Glu/Cr in the left thalamus and the VAS for pain (r = 0.730, P = .007) and between mIns/Cr in the right VLPFC and the VAS for pain (r = 0.607, P = .037) and the FIQ (r = 0.719, P = .008). CONCLUSIONS: The presence of elevated Glu/Cr levels in VLPFC strengthens the opinion that a complex neurophysiologic imbalance of different brain areas involved in pain processing underlies FM. These data may be useful in the diagnosis and development of more effective pharmacologic treatments.
Fast Preconditioners for Total Variation Deblurring with Antireflective Boundary Conditions

In recent works several authors have proposed the use of precise boundary conditions (BCs) for blurring models, and they proved that the resulting choice (Neumann or reflective, antireflective) leads to fast algorithms both for deblurring and for detecting the regularization parameters in presence of noise. When considering a symmetric point spread function, the crucial fact is that such BCs are related to fast trigonometric transforms. In this paper we combine the use of precise BCs with the total variation (TV) approach in order to preserve the jumps of the given signal (edges of the given image) as much as possible. We consider a classic fixed point method with a preconditioned Krylov method (usually the conjugate gradient method) for the inner iteration. Based on fast trigonometric transforms, we propose some preconditioning strategies that are suitable for reflective and antireflective BCs. A theoretical analysis motivates the choice of our preconditioners, and an extensive numerical experimentation .
Mechanical Thrombectomy for Acute Ischemic Stroke: Thrombus–Device Interaction, Efficiency, and Complications In Vivo

Background and Purpose— Mechanical thrombectomy is a promising new modality of interventional stroke treatment. The various devices differ with regard to where they apply force on the thrombus, taking a proximal approach such as aspiration devices or a distal approach such as basket-like devices. The study compares the in vivo effectiveness and thrombus–device interaction of these 2 approaches. Methods— Angiography and embolization with a radioopaque whole blood thrombus was performed in 10 swine. Mechanical thrombectomy was performed in 20 cranial vessels using a proximal aspiration device (Vasco35) and a distal basket-like device (Catch) with and without proximal balloon occlusion. Fifty-six retrieval attempts were made. Results— The proximal device allowed fast repeated application with a low risk of thromboembolic events (3%) and vasospasm, but it had a significantly lower success rate (39.4%) in retrieving thrombotic material than the distal device (DD) (82.6%; odds ratio, 7.3; 95% CI, 2.0 to 26.4). The compaction of the thrombus during retrieval with DD increased the risk of vessel wall irritation significantly (P<0.01) and complicated retrieval into the guiding catheter. The number of embolic events was significantly higher with DD (26%; odds ratio, 11.3; 95% CI, 1.35 to 101.6) unless proximal balloon occlusion was used. Conclusions— The proximal and the distal approaches to mechanical thrombectomy proved to be effective at achieving recanalization of cranial vessels. The proximal device is faster in application and allowed repeated attempts with a low complication rate. The DD is more successful at removing thrombotic material, but its method of application and attendant thrombus compaction increase the risk of thromboembolic events and vasospasms.
Degenerative lumbar spinal stenosis. Decompression with and without arthrodesis.

We prospectively evaluated the results of decompression of the spine, with and without arthrodesis, for the treatment of lumbar spinal stenosis without instability in forty-five patients (twenty-one men and twenty-four women) who had been managed between November 1989 and November 1990. The average age at the time of the operation was sixty-seven years (range, forty-eight to eighty-seven years). The patients were randomly assigned to one of three treatment groups (fifteen patients in each group) according to when they were admitted to the hospital. Group I was treated with decompression with laminotomy and medial facetectomy; Group II, with decompression and arthrodesis of the most stenotic segment; and Group III, with decompression and arthrodesis of all of the decompressed vertebral segments. All of the operations were performed by the same surgeon. The average duration of follow-up was twenty-eight months (range, twenty-four to thirty-two months). All three groups had a significant improvement in the distance that the patients were able to walk at the time of the latest follow-up examination compared with before the operation (p < 0.001 for Group I, p < 0.002 for Group II, and p < 0.005 for Group III). With the numbers available, there were no significant differences in the results among the three groups with regard to the relief of pain (p = 0.25 for Group I compared with Group II, p = 0.36 for Group II compared with Group III, and p = 0.92 for Group I compared with Group III). (ABSTRACT TRUNCATED AT 250 WORDS)
Induced Innovation and Energy Prices

I use U.S. patent data from 1970 to 1994 to estimate the effect of energy prices on energy-efficient innovations. Using patent citations to construct a measure of the usefulness of the existing base of scientific knowledge, I consider the effect of both demand-side factors, which spur innovative activity by increasing the value of new innovations, and supply-side factors, such as scientific advancements that make new innovations possible. I find that both energy prices and the quality of existing knowledge have strongly significant positive effects on innovation. Furthermore, I show that omitting the quality of knowledge adversely affects the estimation results.