Miracle-dz/UniFAR-FTUs huggingface dataset:
Magnetic Resonance Imaging (MRI) and Transvaginal Ultrasonography (TVU) at Ovarian Pain Caused by Benign Ovarian Lesions

Research goal: The aim of the research is to define the possibilities of TVU and the MRI in the diagnosis of the most common benign ovarian lesions which cause pelvic pain. Patients and methods: In study were included n=74 patients with pelvic pain, who were examined with TVU and then with an MRI of pelvis. Diagnostic results of all patients (n=74) divided into two groups according to the modality that was performed (TVU results n=74 and MRI results n=74 MRI ). We compared the results of TVU and MRI, and with a pathohistological finding after surgery. TVU test sensitivity and MRI test sensitivity has been made for each pathological entity in particular. The overall sensitivity test of TVU was performed for all pathological entities together. The overall sensitivity test of MRI was performed for all pathological entities together. Results: TVU demonstrated sensitivity of 83.3% for ectopic pregnancy, 83.3% for ovarian torsion, 84% for endometriotic cyst, 88.2% for hemorrhagic cysts, 58.3% for tubo-ovarian abscesses, 62.5% for dermoid cysts. Overall sensitivity of TVU for all these pathological entities was 78.4%. MRI showed a sensitivity of 100% for ovarian ectopic pregnancy, 83.3% for ovarian torsion, 100% for endometriotic cyst, 100% of hemorrhagic cysts, 83.3% tubo-ovarian abscess, and 87.5% for dermoid cysts. Overall sensitivity of MRI in all of these pathological entities was 94.6%. The analysis using the chi square test shows that there is a significant difference in the sensitivity between the US and MRI in favor of greater overall MRI sensitivity in diagnosing ovarian pain caused by benign lesions. (χ2 = 14.352, df = 9, p = 0.0021). Conclusion: TVU is the first choice method for ovarian analysis due to the convenience and absence of radiation, and MRI is a very useful modality when TVU’s results are confusing and unspecific.
Adaptive functioning, psychopathology and service use among 18-year-old boys with drunkenness-related alcohol use.

AIMS To study the associations between drunkenness frequency and adaptive functioning, psychopathology and service use among 18-year-old Finnish boys in a nation-wide population-based study. METHODS Information about drunkenness frequency within the previous six months was collected from the Finnish boys born in 1981 (n = 2306) at the boys' obligatory military call-up in 1999. Self-report questionnaires were used to study demographic factors, adaptive functioning, risk behaviour, life events, and mental health service use. Psychopathology and adaptive functioning was assessed with the Young Adult Self-Report (YASR) questionnaire. RESULTS Of the boys, 85% reported drunkenness within the previous 6 months. Most of the subjects were occasionally drunk: 39% reported drunkenness less than a month, and 35% less than once a week, while 10% reported being frequently drunk once a week or more often. Occasional drunkenness was associated with better adaptive functioning and psychosocial well-being in general. Refraining from drunkenness was associated with suicidal ideation and internalizing problems in the YASR scale. Frequent drunkenness associated with daily smoking, illicit drug use, and externalizing problems in the YASR scale, especially delinquent behaviour. In the multivariate analysis, number of friends, having a regular relationship and cigarette smoking had a linear association with frequency of drunkenness, while drunkenness-related alcohol use was less common among those with poor friendship quality. Among the participants, entering substance use treatment was rare (0.2%). Frequent drunkenness was found to be common among mental health service users. CONCLUSIONS Among late-adolescent boys, occasional drunkenness is a normative alcohol use pattern and associates with social competence and good psychosocial functioning. Late-adolescent boys refraining from drunkenness in addition to those with frequent drunkenness may be in a need of mental health assessment. As entering substance use treatment is infrequent, establishing integrated services with multi-professional co-operation for late-adolescent males with frequent drunkenness is emphasized.
REDUCING THE PEAK TO AVERAGE POWER RATIO OF MIMO-OFDM SYSTEMS

In this paper, we proposed a particle swarm optimization (PSO) based partial transmit sequence (PTS) technique in order to achieve the lowest Peak-to-Average Power Ratio(PAPR) in Multiple Input Multiple Output- Orthogonal Frequency Division Multiplexing (MIMO-OFDM) systems. Our approach consist of applying the PSO based PTS on each antenna of the system in order to find the optimal phase factors, which is a straightforward method to get the minimum PAPR in such a system. The simulation results demonstrate that the PSO based PTS algorithm when applied to MIMO-OFDM systems with a wide range of phase factors, tends to give a high performance. In addition, there is no need to increase the number of particles of the PSO algorithm to enhance the performance of the system. As a result of this, the complexity of finding the minimum PAPR is kept at a reasonable level.
Value iteration convergence of ε-monotone schemes for stationary Hamilton-Jacobi equations

We present an abstract convergence result for the xed point approximation of stationary Hamilton{Jacobi equations. The basic assumptions on the discrete operator are invariance with respect to the addition of constants, "-monotonicity and consistency. The result can be applied to various high-order approximation schemes which are illustrated in the paper. Several applications to Hamilton{Jacobi equations and numerical tests are presented.
Transplantation of adipose tissue mesenchymal cells conjugated with VEGF-releasing microcarriers promotes repair in murine myocardial infarction.

RATIONALE Engraftment and survival of transplanted stem or stromal cells in the microenvironment of host tissues may be improved by combining such cells with scaffolds to delay apoptosis and enhance regenerative properties. AIMS We examined whether poly(lactic-co-glycolic acid) pharmacologically active microcarriers (PAMs) releasing vascular endothelial growth factor (VEGF) enhance survival, differentiation, and angiogenesis of adipose tissue-mesenchymal stromal cells (AT-MSCs). We analysed the efficacy of transplanted AT-MSCs conjugated with PAMs in a murine model of acute myocardial infarction (AMI). METHODS AND RESULTS We used fibronectin-coated (empty) PAMs or VEGF-releasing PAMs covered with murine AT-MSCs. Twelve-month-old C57 mice underwent coronary artery ligation to induce AMI, and were randomized into five treatment groups: AMI control (saline 20 µL, n = 7), AMI followed by intramyocardial injection with AT-MSCs (2.5 × 10(5) cells/20 µL, n = 5), or concentrated medium (CM) from AT-MSCs (20 µL, n = 8), or AT-MSCs (2.5 × 10(5) cells/20 µL) conjugated with empty PAMs (n = 7), or VEGF-releasing PAMs (n = 8). Sham-operated mice (n = 7) were used as controls. VEGF-releasing PAMs increased proliferation and angiogenic potential of AT-MSCs, but did not impact their osteogenic or adipogenic differentiation. AT-MSCs conjugated with VEGF-releasing PAMs inhibited apoptosis, decreased fibrosis, increased arteriogenesis and the number of cardiac-resident Ki-67 positive cells, and improved myocardial fractional shortening compared with AT-MSCs alone when transplanted into the infarcted hearts of C57 mice. With the exception of fractional shortening, all such effects of AT-MSCs conjugated with VEGF-PAMs were paralleled by the injection of CM. CONCLUSIONS AT-MSCs conjugated with VEGF-releasing PAMs exert paracrine effects that may have therapeutic applications.
Fairness and its impact on delay in 802.11 networks

We analyze in this paper the fairness of the 802.11 DCF (distributed coordination function) access method. Short-term fairness is an important property of a MAC layer for obtaining short delays. We show that contrary to the common wisdom, a 802.11 cell with two hosts does not exhibit short-term unfairness. We propose a new fairness index: the number of inter-transmissions that other hosts may perform between two transmissions of a given host. By means of this index, we analyze the fairness of 802.11 for the case of two hosts and derive the probability distribution of the number of inter-transmissions. Our results show that even on the short term time scale the 802.11 DCF access method provides fairness to competing hosts. When compared with slotted ALOHA, a multiple access randomized protocol with good fairness properties, 802.11 presents even better fairness. To validate the model, we compare the analytical results with experimental histograms obtained via simulations and measurements.
Rate control for UWB mobile radios

This paper shows a technique for regulating the rate emitted by UWB mobile terminals. This technique is designed to adapt the emission rate to the effects of channel capacity variations. We assume that individual flows are shaped at edge routers by means of dual leaky buckets. The proposal is based on the evaluation of certain parameters, which reflect the channel status, sent to the application layer. This information is generated by the scheduler designed to guarantee appropriate channel sharing for the various traffic components. We describe some results which highlight how performance depends on the specific operating conditions, as well as on the traffic descriptors of the flows, their reciprocal difference, and performance requirements.
Routability-Driven Packing: Metrics And Algorithms For Cluster-Based FPGAs

Most of the FPGA's area and delay are due to routing. Considering routability at earlier steps of the CAD flow would both yield better quality and faster design process. In this paper, we discuss the metrics that affect routability in packing logic into clusters. We are presenting a routability-driven clustering method for cluster-based FPGAs. Our method packs LUTs into logic clusters while incorporating routability metrics into a cost function. Based on our routability model, the routability in timing-driven packing algorithm is analyzed. We integrate our routability model into a timing-driven packing algorithm. Our method yields up to 50% improvement in terms of the minimum number of routing tracks compared to VPack (16.5% on average). The average routing area improvement is 27% over VPack and 12% over t-VPack.
Multiple fates of newly synthesized neurofilament proteins: evidence for a stationary neurofilament network distributed nonuniformly along axons of retinal ganglion cell neurons

We have studied the fate of neurofilament proteins (NFPs) in mouse retinal ganglion cell (RGC) neurons from 1 to 180 d after synthesis and examined the proximal-to-distal distribution of the newly synthesized 70-, 140-, and 200-kD subunits along RGC axons relative to the distribution of neurofilaments. Improved methodology for intravitreal delivery of [3H]proline enabled us to quantitate changes in the accumulation and subsequent decline of radiolabeled NFP subunits at various postinjection intervals and, for the first time, to estimate the steady state levels of NFPs in different pools within axons. Two pools of newly synthesized triplet NFPs were distinguished based on their kinetics of disappearance from a 9-mm "axonal window" comprising the optic nerve and tract and their temporal-spatial distribution pattern along axons. The first pool disappeared exponentially between 17 and 45 d after injection with a half-life of 20 d. Its radiolabeled wavefront advanced along axons at 0.5-0.7 mm/d before reaching the distal end of the axonal window at 17 d, indicating that this loss represented the exit of neurofilament proteins composing the slowest phase of axoplasmic transport (SCa or group V) from axons. About 32% of the total pool of radiolabeled neurofilament proteins, however, remained in axons after 45 d and disappeared exponentially at a much slower rate (t 1/2 = 55 d). This second NFP pool assumed a nonuniform distribution along axons that was characterized proximally to distally by a 2.5-fold gradient of increasing radioactivity. This distribution pattern did not change between 45 and 180 d indicating that neurofilament proteins in the second pool constitute a relatively stationary structure in axons. Based on the relative radioactivities and residence time (or turnover) of each neurofilament pool in axons, we estimate that, in the steady state, more neurofilament proteins in mouse RGC axons may be stationary than are undergoing continuous slow axoplasmic transport. This conclusion was supported by biochemical analyses of total NFP content and by electron microscopic morphometric studies of neurofilament distribution along RGC axons. The 70-, 140-, and 200-kD subunits displayed a 2.5-fold proximal to distal gradient of increasing content along RGC axons. Neurofilaments were more numerous at distal axonal levels, paralleling the increased content of NFP. (ABSTRACT TRUNCATED AT 400 WORDS)
Inter-comparison of MERIS, MODIS and MISR cloud top heights

The objective of this study was to asse ss the accuracy of MERIS cloud top pressures through an inter-comparison with CO2-slicing MODIS cloud top pressures and stereo MISR cloud top heights, both instruments of which are onboard the NASA-TERRA platform. For ground-based “truth” measurements, millimetre wavelength cloud radars data were used at the ARM SGP and UK Chilbolton sites. Cloud top pressures were transformed into heights using ECMWF Operational analysis profiles. An ex cellent agreement was found between MERIS, MISR and the radar cloud top heights when single opaque clouds were present. When clouds were optically thin, MERIS cloud top pressure retrievals were not available and when more than one cloud layer was present, MERIS CTH often referred to the lowest cloud top or some altitude between cloud layers. MISR cloud top height s referred to low clouds in mu ltiple layers conditions, due to their higher contrast, and MODIS CTHs were found too low for low clouds, slightly too high for mid-level clouds and within the cloud extent or near the top of high clouds.
A qualitative analysis of conflict types and dimensions in

I thank the interviewed organizational members for their assistance and patience and Jonathon Blake, Roxanne Jones-Toler, Keith Murnighan, and Keith Weigelt for their assistance on this paper. This paper presents a multifaceted qualitative investigation of everyday conflict in six organizational work teams. Repeated interviews and on-site observations provide data on participants' perceptions, behaviors, and their own analyses of their conflicts, resulting in a generalized conflict model. Model evaluation indicates that relationship conflict is detrimental to performance and satisfaction; process conflict is also detrimental to performance; and task conflict's effects on performance depend on specified dimensions. In particular, emotionality reduces effectiveness, resolution potential and acceptability norms increase effectiveness, and importance accentuates conflict's other effects. Groups with norms that accept task but not relationship conflict are most effective. The model and the findings help to broaden understanding of dynamics of organizational conflict and suggest ways it can either be alleviated or wisely encouraged. '
Clinical decision-making of cardiologists regarding admission and treatment of patients with suspected unstable angina or non-ST-elevation myocardial infarction: protocol of a clinical vignette study

Introduction Cardiologists face the difficult task of rapidly distinguishing cardiac-related chest pain from other conditions, and to thoroughly consider whether invasive diagnostic procedures or treatments are indicated. The use of cardiac risk-scoring instruments has been recommended in international cardiac guidelines. However, it is unknown to what degree cardiac risk scores and other clinical information influence cardiologists’ decision-making. This paper describes the development of a binary choice experiment using realistic descriptions of clinical cases. The study aims to determine the importance cardiologists put on different types of clinical information, including cardiac risk scores, when deciding on the management of patients with suspected unstable angina or non-ST-elevation myocardial infarction. Methods and analysis Cardiologists were asked, in a nationwide survey, to weigh different clinical factors in decision-making regarding patient admission and treatment using realistic descriptions of patients in which specific characteristics are varied in a systematic way (eg, web-based clinical vignettes). These vignettes represent patients with suspected unstable angina or non-ST-elevation myocardial infarction. Associations between several clinical characteristics, with cardiologists’ management decisions, will be analysed using generalised linear mixed models. Ethics and dissemination The study has received ethics approval and informed consent will be obtained from all participating cardiologists. The results of the study will provide insight into the relative importance of cardiac risk scores and other clinical information in cardiac decision-making. Further, the results indicate cardiologists’ adherence to the European Society of Cardiology guideline recommendations. In addition, the detailed description of the method of vignette development applied in this study could assist other researchers or clinicians in creating future choice experiments.
Deep Convolutional Inverse Graphics Network

This paper presents the Deep Convolution Inverse Graphics Network (DC-IGN), a model that aims to learn an interpretable representation of images, disentangled with respect to three-dimensional scene structure and viewing transformations such as depth rotations and lighting variations. The DC-IGN model is composed of multiple layers of convolution and de-convolution operators and is trained using the Stochastic Gradient Variational Bayes (SGVB) algorithm [10]. We propose a training procedure to encourage neurons in the graphics code layer to represent a specific transformation (e.g. pose or light). Given a single input image, our model can generate new images of the same object with variations in pose and lighting. We present qualitative and quantitative tests of the model's efficacy at learning a 3D rendering engine for varied object classes including faces and chairs.
CityPersons: A Diverse Dataset for Pedestrian Detection

Convnets have enabled significant progress in pedestrian detection recently, but there are still open questions regarding suitable architectures and training data. We revisit CNN design and point out key adaptations, enabling plain FasterRCNN to obtain state-of-the-art results on the Caltech dataset. To achieve further improvement from more and better data, we introduce CityPersons, a new set of person annotations on top of the Cityscapes dataset. The diversity of CityPersons allows us for the first time to train one single CNN model that generalizes well over multiple benchmarks. Moreover, with additional training with CityPersons, we obtain top results using FasterRCNN on Caltech, improving especially for more difficult cases (heavy occlusion and small scale) and providing higher localization quality.
Pharmacodynamics of moxifloxacin against a high inoculum of Escherichia coli in an in vitro infection model.

OBJECTIVES Escherichia coli is the leading bacterial species implicated in intra-abdominal infections. In these infections a high bacterial burden with pre-existing resistant mutants are likely to be encountered and resistance could be amplified with suboptimal dosing. Our objective was to investigate the pharmacodynamics of moxifloxacin against a high inoculum of E. coli using an in vitro hollow fibre infection model (HFIM). METHODS Three wild-type strains of E. coli (ATCC 25922, MG1655 and EC28044) were studied by exposing approximately 2 x 10(8) cfu/mL (20 mL) to escalating dosing regimens of moxifloxacin (ranging from 30 to 400 mg, once daily). Serial samples were obtained from HFIM over 120 h to enumerate the total and resistant subpopulation. Quinolone resistance-determining regions of gyrA and parC of resistant isolates were sequenced to confirm the mechanism of resistance. RESULTS The pre-exposure MIC of the three wild-type strains was 0.0625 mg/L. Simulated moxifloxacin concentration profiles in HFIM were satisfactory (r(2) >or= 0.94). Placebo experiments revealed natural mutants, but no resistance amplification. Regrowth and resistance amplification was observed between 30 mg/day (AUC/MIC = 47) and 80 mg/day dose (AUC/MIC = 117). Sustained bacterial suppression was achieved at >or=120 mg/day dose (AUC/MIC = 180). Point mutations in gyrA (D87G or S83L) were detected in resistant isolates. CONCLUSIONS Our results suggest that suboptimal dosing may facilitate resistance amplification in a high inoculum of E. coli. The clinical dose of moxifloxacin (400 mg/day) was adequate to suppress resistance development in three wild-type strains. Clinical relevance of these findings warrants further in vivo investigation.
Optical approach for the thermal partition function of photons

The optical manifold method to compute the one-loop effective action in a static space-time is extended from the massless scalar field to the Maxwell field in any Feynman-like covariant gauge. The method is applied to the case of the Rindler space obtaining the same results as the point-splitting procedure. The result is free from Kabat's surface terms which instead affect the $\ensuremath{\zeta}$-function or heat-kernel approaches working directly in the static manifold containing conical singularities. The relation between the optical method and the direct $\ensuremath{\zeta}$-function approach on the Euclidean Rindler manifold is discussed both in the scalar and the photon cases. Problems with the thermodynamic self-consistency of the results obtained from the stress tensor in the case of the Rindler space are pointed out.
Gene Promoter Evolution Targets the Center of the Human Protein Interaction Network

Assessing the contribution of promoters and coding sequences to gene evolution is an important step toward discovering the major genetic determinants of human evolution. Many specific examples have revealed the evolutionary importance of cis-regulatory regions. However, the relative contribution of regulatory and coding regions to the evolutionary process and whether systemic factors differentially influence their evolution remains unclear. To address these questions, we carried out an analysis at the genome scale to identify signatures of positive selection in human proximal promoters. Next, we examined whether genes with positively selected promoters (Prom+ genes) show systemic differences with respect to a set of genes with positively selected protein-coding regions (Cod+ genes). We found that the number of genes in each set was not significantly different (8.1% and 8.5%, respectively). Furthermore, a functional analysis showed that, in both cases, positive selection affects almost all biological processes and only a few genes of each group are located in enriched categories, indicating that promoters and coding regions are not evolutionarily specialized with respect to gene function. On the other hand, we show that the topology of the human protein network has a different influence on the molecular evolution of proximal promoters and coding regions. Notably, Prom+ genes have an unexpectedly high centrality when compared with a reference distribution (P = 0.008, for Eigenvalue centrality). Moreover, the frequency of Prom+ genes increases from the periphery to the center of the protein network (P = 0.02, for the logistic regression coefficient). This means that gene centrality does not constrain the evolution of proximal promoters, unlike the case with coding regions, and further indicates that the evolution of proximal promoters is more efficient in the center of the protein network than in the periphery. These results show that proximal promoters have had a systemic contribution to human evolution by increasing the participation of central genes in the evolutionary process.