Miracle-dz/UniFAR-FTUs huggingface dataset:
A Monte Carlo study on electron and neutron contamination caused by the presence of hip prosthesis in photon mode of a 15 MV Siemens PRIMUS linac

Several investigators have pointed out that electron and neutron contamination from high‐energy photon beams are clinically important. The aim of this study is to assess electron and neutron contamination production by various prostheses in a high‐energy photon beam of a medical linac. A 15 MV Siemens PRIMUS linac was simulated by MCNPX Monte Carlo (MC) code and the results of percentage depth dose (PDD) and dose profile values were compared with the measured data. Electron and neutron contaminations were calculated on the beam's central axis for Co‐Cr‐Mo, stainless steel, Ti‐alloy, and Ti hip prostheses through MC simulations. Dose increase factor (DIF) was calculated as the ratio of electron (neutron) dose at a point for 10×10 cm2 field size in presence of prosthesis to that at the same point in absence of prosthesis. DIF was estimated at different depths in a water phantom. Our MC‐calculated PDD and dose profile data are in good agreement with the corresponding measured values. Maximum dose increase factor for electron contamination for Co‐Cr‐Mo, stainless steel, Ti‐alloy, and Ti prostheses were equal to 1.18, 1.16, 1.16, and 1.14, respectively. The corresponding values for neutron contamination were respectively equal to: 184.55, 137.33, 40.66, and 43.17. Titanium‐based prostheses are recommended for the orthopedic practice of hip junction replacement. When treatment planning for a patient with hip prosthesis is performed for a high‐energy photon beam, attempt should be made to ensure that the prosthesis is not exposed to primary photons. PACS numbers: 87.56. bd, 87.55. kh, 87.55. Gh
HOW CEO ATTRIBUTES AFFECT FIRM R&D SPENDING? NEW EVIDENCE FROM A PANEL OF FRENCH FIRMS

This study investigates empirically the relationship between CEO attributes and RD R&D spending is negatively (positively) associated with CEO ownership at low (high) levels of CEO stockholding. This result implies that at low levels of CEO ownership, an increase in CEO ownership exacerbates CEO myopia and the under-investment problem with regard to R&D activities. However, at high levels of CEO ownership, CEO becomes more willing to invest in risky R&D projects which may reflect a closer alignment of managers' and shareholders' interests.
Comparison of the Gene Expression Profiles from Normal and Fgfrl1 Deficient Mouse Kidneys Reveals Downstream Targets of Fgfrl1 Signaling

Fgfrl1 (fibroblast growth factor receptor-like 1) is a transmembrane receptor that is essential for the development of the metanephric kidney. It is expressed in all nascent nephrogenic structures and in the ureteric bud. Fgfrl1 null mice fail to develop the metanephric kidneys. Mutant kidney rudiments show a dramatic reduction of ureteric branching and a lack of mesenchymal-to-epithelial transition. Here, we compared the expression profiles of wildtype and Fgfrl1 mutant kidneys to identify genes that act downstream of Fgfrl1 signaling during the early steps of nephron formation. We detected 56 differentially expressed transcripts with 2-fold or greater reduction, among them many genes involved in Fgf, Wnt, Bmp, Notch, and Six/Eya/Dach signaling. We validated the microarray data by qPCR and whole-mount in situ hybridization and showed the expression pattern of candidate genes in normal kidneys. Some of these genes might play an important role during early nephron formation. Our study should help to define the minimal set of genes that is required to form a functional nephron.
Radiation dose reduction for CT lung cancer screening using ASIR and MBIR: a phantom study

The purpose of this study was to reduce the radiation dosage associated with computed tomography (CT) lung cancer screening while maintaining overall diagnostic image quality and definition of ground‐glass opacities (GGOs). A lung screening phantom and a multipurpose chest phantom were used to quantitatively assess the performance of two iterative image reconstruction algorithms (adaptive statistical iterative reconstruction (ASIR) and model‐based iterative reconstruction (MBIR)) used in conjunction with reduced tube currents relative to a standard clinical lung cancer screening protocol (51 effective mAs (3.9 mGy) and filtered back‐projection (FBP) reconstruction). To further assess the algorithms' performances, qualitative image analysis was conducted (in the form of a reader study) using the multipurpose chest phantom, which was implanted with GGOs of two densities. Our quantitative image analysis indicated that tube current, and thus radiation dose, could be reduced by 40% or 80% from ASIR or MBIR, respectively, compared with conventional FBP, while maintaining similar image noise magnitude and contrast‐to‐noise ratio. The qualitative portion of our study, which assessed reader preference, yielded similar results, indicating that dose could be reduced by 60% (to 20 effective mAs (1.6 mGy)) with either ASIR or MBIR, while maintaining GGO definition. Additionally, the readers' preferences (as indicated by their ratings) regarding overall image quality were equal or better (for a given dose) when using ASIR or MBIR, compared with FBP. In conclusion, combining ASIR or MBIR with reduced tube current may allow for lower doses while maintaining overall diagnostic image quality, as well as GGO definition, during CT lung cancer screening. PACS numbers: 87.57. Q‐, 87.57. nf
Demotivating Factors Affecting EFL Learning of Iranian Seminary Students.

In the present study, an attempt has been made to determine the demotives affecting EFL learning of Iranian Islamic seminary students and also to distinguish the motivated and demotivated EFL learners in terms of their EFL learning as the major focus of this study. Fifty Iranian EFL seminary students were investigated using two validated questionnaires. First a modified version of The Attitude/Motivation Test Battery Questionnaire (AMTB) originally developed by Gardner (2004) was used to determine the degree of learners’ motivation. Second a modified version of Warrington's (2005) questionnaire was administered to determine the demotivating factors from the students' point of view. Then, the IOPT (Interchange Objective Placement Test) was administered to measure the general proficiency of the subjects under study. The comparison of the IOPT score means of the two groups revealed a significant difference in the results of IOPT of students with higher scores in the AMTB and those with lower scores. That is, the more motivated the students were, the higher their IOPT scores were. Furthermore, factors such as the improper method of English teaching, frequency of classes in a week, problems in understanding listening materials and lack of use of English in students’ real life were found to be the essential demotivating factors among Iranian seminary students. Having known the barriers of learning, the teachers and Islamic Propagation Office materials developers can organize their activities so that they would lead to better understanding of the lessons and improvement of teaching programs.
Plasma Based Markers of [11C] PiB-PET Brain Amyloid Burden

Changes in brain amyloid burden have been shown to relate to Alzheimer's disease pathology, and are believed to precede the development of cognitive decline. There is thus a need for inexpensive and non-invasive screening methods that are able to accurately estimate brain amyloid burden as a marker of Alzheimer's disease. One potential method would involve using demographic information and measurements on plasma samples to establish biomarkers of brain amyloid burden; in this study data from the Alzheimer's Disease Neuroimaging Initiative was used to explore this possibility. Sixteen of the analytes on the Rules Based Medicine Human Discovery Multi-Analyte Profile 1.0 panel were found to associate with [11C]-PiB PET measurements. Some of these markers of brain amyloid burden were also found to associate with other AD related phenotypes. Thirteen of these markers of brain amyloid burden – c-peptide, fibrinogen, alpha-1-antitrypsin, pancreatic polypeptide, complement C3, vitronectin, cortisol, AXL receptor kinase, interleukin-3, interleukin-13, matrix metalloproteinase-9 total, apolipoprotein E and immunoglobulin E – were used along with co-variates in multiple linear regression, and were shown by cross-validation to explain >30% of the variance of brain amyloid burden. When a threshold was used to classify subjects as PiB positive, the regression model was found to predict actual PiB positive individuals with a sensitivity of 0.918 and a specificity of 0.545. The number of APOE ϵ 4 alleles and plasma apolipoprotein E level were found to contribute most to this model, and the relationship between these variables and brain amyloid burden was explored.
Understanding Workaholics' Motivations: A Self-Determination Perspective

In order to explain the diverging well-being outcomes of workaholism, this study aimed to examine the motivational orientations that may fuel the two main components of workaholism (i.e. working excessively and working compulsively). Drawings on Self-Determination Theory, both autonomous and controlled motivation were suggested to drive excessive work, which therefore was expected to relate positively to both well-being (i.e. vigor) and ill-health (i.e. exhaustion). Compulsive work, in contrast, was hypothesised to originate exclusively out of controlled motivation and therefore to only associate positively with ill-being. Structural equation modeling in a heterogeneous sample of Belgian white-collar workers (N = 370) confirmed that autonomous motivation associated positively with excessive work, which then related positively to vigor. Controlled motivation correlated positively with compulsive work, which therefore related positively with exhaustion. The hypothesised path from controlled motivation to exhaustion through excessive work was not corroborated. In general, the findings suggest that primarily compulsive work yields associations with ill-being, since it may stem from a qualitatively inferior type of motivation.
Localization Performance of Multiple Vibrotactile Cues on Both Arms

To present information using vibrotactile stimuli in wearable devices, it is fundamental to understand human performance of localizing vibrotactile cues across the skin surface. In this paper, we studied human ability to identify locations of multiple vibrotactile cues activated simultaneously on both arms. Two haptic bands were mounted in proximity to the elbow and shoulder joints on each arm, and two vibrotactile motors were mounted on each band to provide vibration cues to the dorsal and palmar side of the arm. The localization performance under four conditions were compared, with the number of the simultaneously activated cues varying from one to four in each condition. Experimental results illustrate that the rate of correct localization decreases linearly with the increase in the number of activated cues. It was 27.8 percent for three activated cues, and became even lower for four activated cues. An analysis of the correct rate and error patterns show that the layout of vibrotactile cues can have significant effects on the localization performance of multiple vibrotactile cues. These findings might provide guidelines for using vibrotactile cues to guide the simultaneous motion of multiple joints on both arms.
Work or Fun? How Task Construal and Completion Influence Regulatory Behavior

Volitional behaviors can be construed as “work” (extrinsically motivated) or as “fun” (intrinsically motivated). When volitional behaviors are construed as an obligation to work, completing the behavior depletes a consumer, and subsequent self-control becomes more difficult. When volitional behaviors are construed as an opportunity to have fun, completing the behavior vitalizes a consumer, and subsequent self-control becomes easier. Six studies show how individual differences and contextual factors influence the construal of a task, the motivation for completing it, and subsequent regulatory behavior.
Association of common genetic variants in GPCPD1 with scaling of visual cortical surface area in humans

Visual cortical surface area varies two- to threefold between human individuals, is highly heritable, and has been correlated with visual acuity and visual perception. However, it is still largely unknown what specific genetic and environmental factors contribute to normal variation in the area of visual cortex. To identify SNPs associated with the proportional surface area of visual cortex, we performed a genome-wide association study followed by replication in two independent cohorts. We identified one SNP (rs6116869) that replicated in both cohorts and had genome-wide significant association (Pcombined = 3.2 × 10−8). Furthermore, a metaanalysis of imputed SNPs in this genomic region identified a more significantly associated SNP (rs238295; P = 6.5 × 10−9) that was in strong linkage disequilibrium with rs6116869. These SNPs are located within 4 kb of the 5′ UTR of GPCPD1, glycerophosphocholine phosphodiesterase GDE1 homolog (Saccharomyces cerevisiae), which in humans, is more highly expressed in occipital cortex compared with the remainder of cortex than 99.9% of genes genome-wide. Based on these findings, we conclude that this common genetic variation contributes to the proportional area of human visual cortex. We suggest that identifying genes that contribute to normal cortical architecture provides a first step to understanding genetic mechanisms that underlie visual perception.
Pre-Clinical Assessment of the Potential Intrinsic Hepatotoxicity of Candidate Drugs

Innovation is fundamental to discovering new drugs for the variety of human conditions that exist. It is also one of the key requirements for any pharmaceutical organization that wishes to gain a competitive edge. The pharmaceutical industry is profit-driven because it has to fund its own drug innovation, which highlights why research and development (R&D) forms the backbone of this industry. According to the CEO of the Pharmaceutical Research and Manu‐ facturers of America (PhRMA), John Castellani, member companies of PhRMA spent a record US$ 67.4 billion on R&D in 2011. This is approximately 20% of generated revenue, which is 5 times more than the average manufacturing firm invests into R&D [1]. The pharmaceutical sector was responsible for 20% of all R&D expenditures by U.S. businesses in 2011 [2]. The aforesaid figures do not describe global R&D expenditures, but serve to give some indication of the astronomical contributions that are annually devoted by the pharmaceutical industry to drug development.
Standard versus Minimally Invasive Transforaminal Lumbar Interbody Fusion: A Prospective Randomized Study

Symptomatic spondylolisthesis patients may benefit from surgical decompression and stabilization. The standard (S) technique is a transforaminal lumbar interbody fusion (TLIF). Newer, minimally invasive (MI) techniques seem to provide similar results with less morbidity. We enrolled patients with at least 6 months of symptoms and image-confirmed low-grade spondylolisthesis, at a single academic institution, between 2011 and 2015. The patients were randomized to either S or MI TLIF. The primary outcome measure was the Oswestry Disability Index (ODI) improvement at 1 year. Secondary outcome measures included length of operation, estimated blood loss, length of hospitalization, and fusion rates at 1 year. Forty patients were enrolled in each group. The differences in mean operative time and estimated blood loss were not statistically significant between the two groups. The patients were discharged after surgery at 4.12 days for the S TLIF group and 1.92 days for the MI TLIF group. The ODI improvement was similar and statistically significant in both groups. The fusion was considered solid in 36 (90%) of patients at 1 year in both groups. In conclusion, the two techniques provided similar clinical and radiological outcomes at 1 year. The patients undergoing MI TLIF had a shorter hospital stay. This trial is registered with NCT03155789.
Convolutional Point-set Representation: A Convolutional Bridge Between a Densely Annotated Image and 3D Face Alignment

We present a robust method for estimating the facial pose and shape information from a densely annotated facial image. The method relies on Convolutional Point-set Representation (CPR), a carefully designed matrix representation to summarize different layers of information encoded in the set of detected points in the annotated image. The CPR disentangles the dependencies of shape and different pose parameters and enables updating different parameters in a sequential manner via convolutional neural networks and recurrent layers. When updating the pose parameters, we sample reprojection errors along with a predicted direction and update the parameters based on the pattern of reprojection errors. This technique boosts the model's capability in searching a local minimum under challenging scenarios. We also demonstrate that annotation from different sources can be merged under the framework of CPR and contributes to outperforming the current state-of-the-art solutions for 3D face alignment. Experiments indicate the proposed CPRFA (CPR-based Face Alignment) significantly improves 3D alignment accuracy when the densely annotated image contains noise and missing values, which is common under "in-the-wild" acquisition scenarios.
Mesial temporal lobe epilepsy syndrome: an updated overview

Epilepsia de lobo temporal mesial (ELTM) e a forma mais comum de epilepsia parcial em adultos jovens e tambem a mais frequente nas series cirurgicas mundiais. Esclerose mesial temporal (EMT) e a principal causa de ELTM; presente em 60-70% dos pacientes submetidos ao tratamento cirurgico para crises refratarias. Os mecanismos patogenicos desta forma distinta de lesao hipocampal permanecem incertos. Achados recentes sugerem uma malformacao do desenvolvimento do hipocampo (hereditaria ou adquirida) que em associacao com insultos subsequentes (ex. trauma, infeccao, crises febris complexas) poderiam provocar crises recorrentes, resultando nas caracteristicas neuropatologicas da EMT. Substrato genetico, idade e tipo de insulto precipitante inicial e vulnerabilidade relacionada a mecanismos de morte celular programada sao provaveis mecanismos envolvidos no desenvolvimento da EMT. Definicao de resistencia ao tratamento clinico pode variar entre centros especializados, mas geralmente inclui falha no controle de crises apos dois ou mais esquemas adequados de drogas antiepilepticas. A decisao de quando realizar um tratamento cirurgico em pacientes com ELTM e questao relevante e necessita ser investigada com maior profundidade. Evidencia recente discutida nesta revisao indica que duracao prolongada de crises nao controladas se associa a um maior risco de falha no tratamento cirurgico.
Microstructure and mechanical properties of spark plasma sintered TiB2 ceramics combined with a high-entropy alloy sintering aid

ABSTRACT A high-entropy alloy (HEA), CoCrFeNiMn0.5Ti0. 5, is used as a sintering aid for the densification of TiB2 sintered by spark plasma sintering. The HEA content in the starting TiB2-HEA mixture is varied from 0 to 10 wt-%. The microstructure and mechanical properties of the sintered samples are analysed and the optimum HEA content of 10% is found for the preparation of the TiB2-HEA ceramics, allowing combining high mechanical properties (Vickers hardness of 2174.64 HV and flexural strength of 427.69 MPa) and high relative density of 99.1%.
Prognostic impact of physical activity prior to myocardial infarction: Case fatality and subsequent risk of heart failure and death

Background Animal studies indicate that exercise reduces myocardial damage during myocardial infarction by ischaemic preconditioning. Aim To determine from a prospective cohort study whether the level of leisure time physical activity (LTPA) in humans prior to myocardial infarction could modify the course of myocardial infarction by reducing case fatality and the subsequent risk of heart failure and mortality. Methods A total of 14,223 participants in the Copenhagen City Heart Study were assessed at baseline in 1976–1978; 1,664 later developed myocardial infarction (mean age at myocardial infarction 70.9 years) and were followed through registries until 2013. We explored the association of LTPA assessed before myocardial infarction with the risk of fatal myocardial infarction, heart failure and all-cause mortality after myocardial infarction. Odds ratios (ORs) and hazard ratios (HRs) were estimated by logistic and Cox proportional hazards regression models, adjusted for age at myocardial infarction and other potential confounders. Results A total of 425 (25.5%) myocardial infarctions were fatal. Higher levels of LTPA prior to myocardial infarction were associated with lower case fatality: adjusted ORs (95% confidence interval), with reference to sedentary LTPA were 0.68 (0.51–0.89) for light LTPA and 0.53 (0.38–0.74) for moderate/high LTPA. A total of 360 (29.1%) of the 1,239 myocardial infarction survivors developed heart failure and 1,033 (83.4%) died during follow-up. There was no association between LTPA levels prior to myocardial infarction and the risk of heart failure or all-cause mortality after non-fatal myocardial infarction: adjusted HRs for moderate/high versus sedentary LTPA were 1.06 (0.78–1.45) and 0.90 (0.74–1.08), respectively. Conclusion Individuals who were physically active had lower case fatality of myocardial infarction, but survivors were not protected against subsequent heart failure or mortality.
Cortical Circuits from Scratch: A Metaplastic Architecture for the Emergence of Lognormal Firing Rates and Realistic Topology

Our current understanding of neuroplasticity paints a picture of a complex interconnected system of dependent processes which shape cortical structure so as to produce an efficient information processing system. Indeed, the cooperation of these processes is associated with robust, stable, adaptable networks with characteristic features of activity and synaptic topology. However, combining the actions of these mechanisms in models has proven exceptionally difficult and to date no model has been able to do so without significant hand-tuning. Until such a model exists that can successfully combine these mechanisms to form a stable circuit with realistic features, our ability to study neuroplasticity in the context of (more realistic) dynamic networks and potentially reap whatever rewards these features and mechanisms imbue biological networks with is hindered. We introduce a model which combines five known plasticity mechanisms that act on the network as well as a unique metaplastic mechanism which acts on other plasticity mechanisms, to produce a neural circuit model which is both stable and capable of broadly reproducing many characteristic features of cortical networks. The MANA (metaplastic artificial neural architecture) represents the first model of its kind in that it is able to self-organize realistic, nonrandom features of cortical networks, from a null initial state (no synaptic connectivity or neuronal differentiation). In the same vein as models like the SORN (self-organizing recurrent network) MANA represents further progress toward the reverse engineering of the brain at the network level.