Miracle-dz/UniFAR-FTUs huggingface dataset:
Variance Heterogeneity in Saccharomyces cerevisiae Expression Data: Trans-Regulation and Epistasis

Here, we describe the results from the first variance heterogeneity Genome Wide Association Study (VGWAS) on yeast expression data. Using this forward genetics approach, we show that the genetic regulation of gene-expression in the budding yeast, Saccharomyces cerevisiae, includes mechanisms that can lead to variance heterogeneity in the expression between genotypes. Additionally, we performed a mean effect association study (GWAS). Comparing the mean and variance heterogeneity analyses, we find that the mean expression level is under genetic regulation from a larger absolute number of loci but that a higher proportion of the variance controlling loci were trans-regulated. Both mean and variance regulating loci cluster in regulatory hotspots that affect a large number of phenotypes; a single variance-controlling locus, mapping close to DIA2, was found to be involved in more than 10% of the significant associations. It has been suggested in the literature that variance-heterogeneity between the genotypes might be due to genetic interactions. We therefore screened the multi-locus genotype-phenotype maps for several traits where multiple associations were found, for indications of epistasis. Several examples of two and three locus genetic interactions were found to involve variance-controlling loci, with reports from the literature corroborating the functional connections between the loci. By using a new analytical approach to re-analyze a powerful existing dataset, we are thus able to both provide novel insights to the genetic mechanisms involved in the regulation of gene-expression in budding yeast and experimentally validate epistasis as an important mechanism underlying genetic variance-heterogeneity between genotypes.
Getting Serious about Math: Serious Game Design Framework & an Example of a Math Educational Game

Serious games have been increasingly interesting to educators recently, but it is difficult to find good games that truly address the needs of young learners, especially in mathematics. Some games are either too simplistic or are not actual games. In the paper, an argument is made for the benefits of game-based learning (GBL) for instruction and assessment given what we know about Millenials and how they learn. The first aim of this discussion is to suggest a framework for designing serious games based on game features in commercial games, opinions of fourth graders and their teachers, literary studies, contemporary learning theories, as well as successful and unsuccessful similar endeavours. The second part of this paper describes a concrete example of a maths game based on the proposed framework that implicitly tests math and collaboration skills. The game is made of three components: the game itself, a social network, and a teacher reporting tool. Despite a growing interest in GBL, some teachers are reluctant to use serious games in school. To increase usage of serious games as resource, it is important to equip teachers with information and address their concerns. The paper concludes with the idea that serious games need to be designed well in order to provide the immersion and collaborative active learning that most learning theories recommend. Further, that they should be games and not just drill and practice. In that way, they can be even more beneficial than books as part of the teacher's repertoire in school. Future research avenues are also discussed.
Las estrategias de afrontamiento que utilizan los adolescentes ante situaciones que provocan miedo/ Coping strategies assumed by teenagers in situations that cause fear

objetivo: Identificar las estrategias de afrontamiento que usan los adolescentes mexicanos ante situaciones que provocan miedo. Metodo: El tipo de estudio fue no experimental. Los partici- pantes fueron 400 adolescentes mexicanos de nivel secundaria (50 % hombres y 50 % mujeres), Media de edad = 13.90 (DE= 0.96). Un instrumento midio la intensidad del miedo ante nueve tipos de situaciones: violencia social, animales, estar solo, medicos, situaciones sociales, lo desco- nocido, violencia domestica, escuela y muerte (α = .93). Por medio de preguntas abiertas se pre- gunto a los participantes que harian ante cada una de las situaciones, lo que permitio identificar el tipo de afrontamiento. Resultados: Las mujeres informaron mayor miedo que los hombres en todas las situaciones, excepto en miedo a la escuela, donde ellas tuvieron mayor puntaje. El patron general fue que las mujeres usan mas estrategias de desahogo emocional y busqueda de apoyo, mientras que los hombres usan estrategias directas al problema, agresivas y de distraccion. En particular, ante el miedo a la muerte, los hombres usan estrategias evitativas, distraccion y busqueda de apoyo, mientras que las mujeres usan estrategias directas al problema, desahogo emocional, busqueda de apoyo, evitativas, distraccion y agresivas. Ante el miedo a lo desconocido, los varones usan estrategias de distraccion, agresivas y directas al problema, mientras que las muje- res usan desahogo emocional, directo al problema y agresivas. Las estrategias de afrontamiento no son buenas ni malas, su conveniencia depende del apoyo que brindan para resolver la situacion que genera miedo.
DONALDSON–THOMAS INVARIANTS OF LOCAL ELLIPTIC SURFACES VIA THE TOPOLOGICAL VERTEX

We compute the Donaldson–Thomas invariants of a local elliptic surface with section. We introduce a new computational technique which is a mixture of motivic and toric methods. This allows us to write the partition function for the invariants in terms of the topological vertex. Utilizing identities for the topological vertex proved in Bryan et al. [‘Trace identities for the topological vertex’, Selecta Math. (N.S.) 24 (2) (2018), 1527–1548, arXiv:math/1603.05271], we derive product formulas for the partition functions. The connected version of the partition function is written in terms of Jacobi forms. In the special case where the elliptic surface is a K3 surface, we get a derivation of the Katz–Klemm–Vafa formula for primitive curve classes which is independent of the computation of Kawai–Yoshioka.
The SAURON project – VIII. OASIS/CFHT integral-field spectroscopy of elliptical and lenticular galaxy centres

We present high spatial resolution integral-field spectros copy of 28 elliptical (E) and lenticular (S0) galaxies from the SAURON representative survey obtained with the OASIS spectrograph during its operation at the CFHT. These seeing-limited observations explore the central 8 ′′ ×10 ′′ (typically one kiloparsec diameter) regions of these galax ies using a spatial sampling four times higher than SAURON (0. 27 vs. 0. 94 spatial elements), resulting in almost a factor of two improvement in the median PSF. These data allow accurate study of the central regions to complement the large-scale view provided by SAURON. Here we present the stellar and gas kinematics, stellar absorption-line strengths and neb ular emission-line strengths for this sample. We also characterise the stellar velocity maps using the ‘kinemetry’ technique, and derive maps of the luminosity-weighted stellar age, metallicity and abundance ratio via stellar population models. We give a brief review of the structures found in our maps, linking also to larger-scale structures measured with SAURON. We present two previously unreported kinematically-decoupled components (KDCs) in the centres of NGC 3032 and NGC 4382. We compare the intrinsic size and luminosity-weighted stellar age of all the visible KDCs in the full SAURON sample, and find two types of components: kiloparsec-scale K DCs, which are older than 8 Gyr, and are found in galaxies with little net rot ation; and compact KDCs, which have intrinsic diameters of less than a few hundred parsec, show a range of stellar ages from 0.5 - 15 Gyr (with 5/6 younger than 5 Gyr), are found exclusively in fast-rotating galaxies, and are close to counter-rotating around the same axis as their host. Of the 7 galaxies in the SAURON sample with integrated luminosity-weighted ages less than 5 Gyr, 5 show such compact KDCs, suggesting a link between counter-rotation and recent star-formation. We show that this may be due to a combination of small sample size at young ages, and an observational bias, since young KDCs are easier to detect than their older and/or co-rotating counterparts.
Out of Sight, (Not Yet) Out of Mind: The Impact of Tie Strength on Direct Interaction and Social Surveillance Among Geographically Close and Long-Distance Facebook Friends

Social networking sites are considered a valuable resource to maintain existing friendships even over considerable distances. The present study emphasizes tie strength as a crucial determinant for the use of interactive and passive features among 302 active Facebook users and friends of different relational closeness (close friends vs. casual friends vs. acquaintances) as well as a moderator for the impact of physical distance. As expected, tie strength affected direct interaction linearly, whereas social surveillance followed a quadratic trend. Furthermore, moderation analyses revealed less frequent direct interaction between close friends and stronger surveillance of casual friends’ profiles as physical distance increases. These results indicate different functions in relationship maintenance for both behaviors as direct interaction aims at nurturing current relationships, while surveillance serves as a catalyst for promising future communications. As a consequence, physical distance influences direct interaction adversely due to emerging constraints but also contains informational value encouraging information-seeking behaviors.
ON THE NONRELATIVISTIC LIMIT OF LINEAR WAVE EQUATIONS FOR ZERO AND UNITY SPIN PARTICLES

The nonrelativistic limit of the linear wave equation for zero and unity spin bosons of mass m in the Duffin–Kemmer–Petiau representation is investigated by means of a unitary transformation, analogous to the Foldy–Wouthuysen canonical transformation for a relativistic electron. The interacting case is also analyzed, by considering a power series expansion of the transformed Hamiltonian, thus demonstrating that all features of particle dynamics can be recovered if corrections of order 1/m2 are taken into account through a recursive iteration procedure.
A 10-Month Physical Activity Intervention Improves Body Composition in Young Black Boys

Objective. To determine if a 10-month after-school physical activity (PA) intervention could prevent deleterious changes in body composition and cardiovascular (CV) fitness in young black boys. Methods. Following baseline measures, 106 boys (8–12 yrs) were randomized to either a control group or an intervention group, further divided into attenders (ATT) and nonattenders (NATT), participating in ≥60% or <60% of the intervention, respectively. The daily intervention consisted of skills development (25 min), vigorous PA (VPA, 35 min), and strengthening/stretching (20 min) components. Body composition was measured by dual-energy X-ray absorptiometry. Results. Following the intervention, the ATT exhibited an increase in moderate-to-vigorous PA and a significant reduction in BMI, fat mass, and %BF compared to the control group. A significant association among the intervention energy expenditure and changes in body composition and CV fitness was observed only in the ATT group. Conclusion. An after-school PA program of sufficient length and intensity can promote healthy changes in body composition and fitness levels in black boys who attend at least 3 days/week.
Johnson–Segalman model with a diffusion term in cylindrical Couette flow

We study the Johnson–Segalman (JS) model as a paradigm for some complex fluids which are observed to phase separate, or “shear band” in flow. We analyze the behavior of this model in cylindrical Couette flow and demonstrate the history dependence inherent in the local JS model. We add a simple gradient term to the stress dynamics and demonstrate how this term breaks the degeneracy of the local model and prescribes a much smaller (discrete, rather than continuous) set of banded steady state solutions. We investigate some of the effects of the curvature of Couette flow on the observable steady state behavior and kinetics, and discuss some of the implication for metastability.
Prestimulus theta activity predicts correct source memory retrieval

Recent evidence indicates that the processing of a stimulus can be influenced by preceding patterns of brain activity. Here we examine whether prestimulus oscillatory brain activity can influence the ability to retrieve episodic memories. Neural activity in the theta-frequency band (4–8 Hz) was enhanced before presentation of test items which elicited accurate recollection of contextual details of the prior study episode (“source retrieval”), relative to trials for which item recognition was successful but source retrieval failed. Poststimulus theta activity was also related to source retrieval, and the magnitude of poststimulus theta was predicted by the magnitude of the prestimulus theta effects. The results suggest that ongoing neural processes occurring before stimulus onset might play a critical role in readying the brain for successful memory retrieval.
Kapasitas Petani Padi Sawah Irigasi Teknis dalam Menerapkan Prinsip Pertanian Ramah Lingkungan di Sulawesi Tengah

Kapasitas petani mengelola padi sawah ramah lingkungan di sistem sawah irigasi teknis, menurut karakteristik personal dan peluang pengembangannya, meliputi: kemampuan secara teknis inovasi teknologi, kemampuan menyusun rencana usahatani, kemampuan mengevaluasi, kemampuan beradaptasi terhadap perubahan, dan kemampuan bermitra sinergis. Kemampuan ini, merupakan wujud kapasitas tinggi yang dimiliki petani. Penelitian bertujuan: menganalisis hubungan antara karakteristik petani dengan tingkat kapasitasnya mengelola sawah ramah lingkungan. Pengumpulan data dilakukan melalui wawancara terhadap 174 petani. Analisis data dilakukan uji deskriptif, uji beda Mann Whitney dan uji Rank Spearman , menggunakan program Statistical Product and Service Solution (SPSS) versi 22. Hasil penelitian menunjukkan bahwa petani Kabupaten Sigi dan Parigi Moutong berbeda baik karakteristik maupun kemampuan mengelola usahataninya. Terdapat perbedaan yang nyata pada pendidikan non formal dan luas lahan. Tingkat kapasitas petani dalam pengelolaan padi sawah yang ramah lingkungan pada kategori rendah. Rendahnya kapasitas petani dipengaruhi oleh kemampuan perencanaan usahatani dan kemampuan bermitra sinergis. Hubungan keseluruhan kapasitas petani terhadap kemampuannya menunjukkan bahwa faktor yang berhubungan sangat nyata dan mempengaruhi kapasitas petani adalah pendidikan non formal dan luas lahan. Penelitian ini membuktikan bahwa mereka yang memiliki akses terhadap penyuluhan dan pelatihan usahatani ramah lingkungan secara nyata dapat meningkatkan kapasitas petani, dan petani yang memiliki lahan luas merasakan keuntungan menggelola sawah yang ramah lingkungan dibanding dengan lahan sempit.
Attention-deficit/hyperactivity disorder and preterm birth as a risk factor : a cognitive-neurophysiological sibling-pair investigation

Unless another licence is stated on the immediately following page this work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International licence. https://creativecommons.org/licenses/by-nc-nd/4.0/ You are free to copy, distribute and transmit the work Under the following conditions:  Attribution: You must attribute the work in the manner specified by the author (but not in any way that suggests that they endorse you or your use of the work).  Non Commercial: You may not use this work for commercial purposes.  No Derivative Works You may not alter, transform, or build upon this work.
Decomposing legacy programs: a first step towards migrating to client-server platforms

We propose an approach to program decomposition as a preliminary step for the migration of legacy systems. A program slicing algorithm is defined to identify the statements implementing the user interface component. An interactive re-engineering tool is also presented that supports the software engineer in the comprehension of the source code during the decomposition of a program. The focus of this paper is on the partition of a legacy system, while issues related to the re-engineering, encapsulation, and wrapping of the legacy components and to the definition of the middleware layer through which they communicate are not tackled.
Modeled Wellness: Using Perceived Supervisor Wellness and the Supervisory Relationship to Predict Supervisee Personal Wellness

Wellness has become an increasingly important paradigm for counseling and clinical supervision. A heightened focus on counselor wellness in supervision has emerged as an intervention to improve quality of care to clients and prevent counselor impairment. Although researchers have examined the benefits of wellness interventions in supervision, we have little understanding of the supervisor’s ability to model wellness to their supervisees. Nor have researchers shown how a supervisor’s wellness influences supervisee wellness—and if and how the strength of the supervision relationship changes this influence. Thus, the purpose of this quantitative investigation was to (a) analyze the role of modeled wellness as a way for supervisors to influence the multifaceted aspects of supervisee wellness, and (b) identify if the factoring in the supervisory relationship changes this influence. This quantitative study included a sample of 105 counselor education students enrolled in practicum or internship courses who were receiving supervision from a site-based supervisor. Results indicated that supervisee personal wellness was influenced by the supervisee’s perception of supervisor wellness. Certain second-order factors of perceived supervisor wellness (Creative and Coping Selves) were more predictive of the corresponding factor of supervisee personal wellness. When the strength of the supervisory relationship was considered, the model became more predictive despite the lack of correlation between the strength of the supervisory relationship and supervisee personal wellness. Results from this investigation suggest that the supervisory relationship can act as a suppressor variable, controlling for error in the equation and making the perception of supervisor wellness a more valid predictor. A subsequent correlational analysis suggests that the error in prediction was primarily in supervisory relationships of moderate strength. The combination of the supervisee’s perception of their supervisor’s wellness and the strength of the supervisory relationship predicted 9% of the variance in supervisee wellness. Implications for counselors, supervisors, educators, and policy are discussed. Limitations and recommendations for future inquiry are highlighted based on the findings from this investigation.
Probabilistic Adaptive Random Testing

Adaptive random testing (ART) methods are software testing methods which are based on random testing, but which use additional mechanisms to ensure more even and widespread distributions of test cases over an input domain. Restricted random testing (RRT) is a version of ART which uses exclusion regions and restricts test case generation to outside of these regions. RRT has been found to perform very well, but its use of strict exclusion regions (from within which test cases cannot be generated) has prompted an investigation into the possibility of modifying the RRT method such that all portions of the input domain remain available for test case generation throughout the duration of the algorithm. In this paper, we present a probabilistic approach, probabilistic ART (PART), and explain two different implementations. Preliminary empirical data supporting the methods is also examined
Shame experiences and Problematic Social Networking Sites Use: an unexplored association

Objective: The current study investigates the main and indirect effects of shame experiences and perceived benefits of computer-mediated communication (CMC) compared with face-to-face communication, on Problematic Social Networking Sites Use (PSNSU). In particular, a model in which perceived benefits of CMC (i.e. escapism, control over self-presentation, and approval/acceptance) mediate the association between shame and PSNSU was tested. Method: A sample of 590 undergraduate students (mean age = 22.29 + 2.079; females = 53.2%) completed measures of shame experiences, perceived benefits of CMC and PSNSU. Results: The assessed structural model produced adequate fit to the data (χ2= 352.99; df = 92; p <.001; RMSEA [90% CI] =.07 [.06-.08]; CFI = .97; SRMR = .06). Variables accounted for 50% of the variance in PSNSU. A partial mediation model in which shame predicted PSNSU levels through the perceived benefits of CMC was found. A direct relationship between shame and PSNSU was also detected. Conclusions: The current study highlights how feelings of shame can contribute to problematic use of SNS and emphasizes the necessity of taking into account the perceived benefits of CMC when exploring psychological risk
Measuring Banks' Automated Service Quality: A Confirmatory Factor Analysis Approach

Automated service quality has been recognised as the factor which determines the suc cess or failure of electronic commerce. Those models current ly available to measure automated service quality are limited in their focus, encompassing only one electronic channel – the internet – thereby ignoring attributes of the other automated service channels. In relation to the banking sector, research has identified that bank customers tend to use a combination of automated service channe ls. As such, this research strives to develop a comprehensive model of banking automated service quality taking into consideration the unique attributes of each delivery channel and other dimensions that have a potential influence on quality issues. The proposed model has been empirically tested for unidimensionality, reliability, and validity using confirmatory factor analysis.
Optimal Immigration Policy: Permanent, Guest-Worker, or Mode IV?

Immigration continues to be on the forefront of the policy debate on both sides of the Atlantic. A number of reforms of permanent and guest-worker (GW) immigration programs are being considered, and the temporary movement of service providers under Mode IV (GATS) is being negotiated at the Doha Round of the WTO. This paper contributes to the debate by examining these programs in a model where the host country government maximizes its objective function with respect to three policy instruments: the share of migrants’ deferred income payment, the value of the bond employers must post and forfeit if GWs overstay, and the size of the program. Circular migration and illegal GWs’ status regularization are considered. The paper shows that i) the optimal value of the bond is zero, ii) Mode IV is preferable to GW migration; iii) the optimal policy package consists of Mode IV and permanent migration, and iv) incorporating circular migration improves the policy package. Additional policy implications are also provided.