Miracle-dz/UniFAR-FTUs huggingface dataset:
Diesel Exhaust Exposure and the Risk of Lung Cancer—A Review of the Epidemiological Evidence

To critically evaluate the association between diesel exhaust (DE) exposure and the risk of lung cancer, we conducted a systematic review of published epidemiological evidences. To comprehensively identify original studies on the association between DE exposure and the risk of lung cancer, literature searches were performed in literature databases for the period between 1970 and 2013, including bibliographies and cross-referencing. In total, 42 cohort studies and 32 case-control studies were identified in which the association between DE exposures and lung cancer was examined. In general, previous studies suffer from a series of methodological limitations, including design, exposure assessment methods and statistical analysis used. A lack of objective exposure information appears to be the main problem in interpreting epidemiological evidence. To facilitate the interpretation and comparison of previous studies, a job-exposure matrix (JEM) of DE exposures was created based on around 4,000 historical industrial measurements. The values from the JEM were considered during interpretation and comparison of previous studies. Overall, neither cohort nor case-control studies indicate a clear exposure-response relationship between DE exposure and lung cancer. Epidemiological studies published to date do not allow a valid quantification of the association between DE and lung cancer.
Electromyographic activity of selected trunk muscles during dynamic spine stabilization exercises.

OBJECTIVES To compare the electromyographic activity of the trunk flexors and extensors during 2 spine stabilization exercises and to evaluate the changes in muscle activity with increasing levels of exercise difficulty. DESIGN Descriptive study. SETTING Research laboratory. PARTICIPANTS Twelve healthy subjects without history of lower back pain. INTERVENTION Subjects were instructed how to perform the Dying Bug and the Quadruped exercises. Electromyographic and motion data were recorded from each muscle group during maximum voluntary isometric contraction (MVIC). MAIN OUTCOME MEASURES Surface electromyographic recordings of the erector spinae, rectus abdominus, abdominal oblique, and gluteus maximus muscles. RESULTS During the Dying Bug exercise, the trunk flexors (rectus abdominus, abdominal oblique) were equally active and demonstrated proportional increases in electromyographic activity with increasing level of exercise difficulty. In the Quadruped exercise, significantly greater electromyographic activity was observed in the abdominal oblique compared with the rectus abdominus; however, abdominal oblique activity did not change with increasing level of difficulty. The erector spinae and gluteus maximus demonstrated a significant level effect and were most active during elevation of the ipsilateral leg. At no point did activity of any of the muscles studied exceed 41% of the MVIC. CONCLUSIONS Results indicated the Dying Bug exercise predominantly recruited the abdominal musculature, while greater activity was observed in the trunk and hip extensors during the Quadruped exercise. The relatively low levels of electromyographic activity observed in both exercises suggests that the intensity of muscle recruitment is not likely sufficient to provide a strengthening effect in healthy subjects.
Eye Micro-movements Improve Stimulus Detection Beyond the Nyquist Limit in the Peripheral Retina

Even under perfect fixation the human eye is under steady motion (tremor, microsaccades, slow drift). The "dynamic" theory of vision [1, 2] states that eye-movements can improve hyperacuity. According to this theory, eye movements are thought to create variable spatial excitation patterns on the photoreceptor grid, which will allow for better spatiotemporal summation at later stages. We reexamine this theory using a realistic model of the vertebrate retina by comparing responses of a resting and a moving eye. The performance of simulated ganglion cells in a hyperacuity task is evaluated by ideal observer analysis. We find that in the central retina eye-micromovements have no effect on the performance. Here optical blurring limits vernier acuity. In the retinal periphery however, eye-micromovements clearly improve performance. Based on ROC analysis, our predictions are quantitatively testable in electro-physiological and psychophysical experiments.
First results of the Fermilab high-brightness RF photoinjector

A collaboration has been formed between FNAL, UCLA, LNFN Milano, the University of Rochester, and DESY to develop the technology of an RF photoinjector, followed by a superconducting cavity, to produce high bunch charge (8 nC) with low normalized emittance (<20 mm mrad) in bunch spacing trains of 800 bunches separated by /spl mu/s. The activities of bunch charge the collaboration fall into two categories: 1. the development of Injector II for the TeSLA/TTF accelerator. This photoinjector (TTF RF Gun) was tested at Fermilab in September and October 1998 and installed at DESY in November 1998. 2. the installation at the A0 Hall of Fermilab of a modified version of the TTF photoinjector, for photoinjector R&D and to study novel applications of high-brightness, pulsed electron beams. This photoinjector (A0 RF Gun) produced its first beam in March 1999. This paper presents a summary of the tests done at Fermilab on the TITF Injector II and the first results obtained on the new Fermilab photoinjector.
Age structure in neutral theory resolves inconsistencies related to reproductive-size threshold

Aims Neutral theory consists of a suite of models that assume ecological equivalence among individual organisms. They have been most commonly applied to tropical forest tree communities either as null models or as approximations. Neutral models typically only include reproductive adults; therefore, fitting to empirical tree community data requires defining a reproductive-size threshold, which for trees is usually set arbitrarily to a diameter at breast height (DBH) of 100 mm. The inevitable exclusion of some reproductive adults and inclusion of some saplings cause a non-random sampling bias in neutral model fits. Here, we investigate this problem and resolve it by introducing simple age structure into a neutral model. Methods We compared the performance and sensitivity of DBH threshold of three variants of a spatially explicit neutral model: the traditional model, a model incorporating random sampling and a model with two distinct age classes—reproductive adults and saplings. In the age-structured model, saplings are offspring from adults that disperse according to a Gaussian dispersal kernel around the adults. The only extra parameter is the ratio of adults to saplings, which is not a free parameter but directly measurable. We used species–area relationships (SARs) to explore the predicted effect of saplings on the species richness at different scales in our model. We then evaluated the three model variations to find the parameters required to maintain the observed level of species richness in the 50-ha plot on Barro Colorado Island (BCI). We repeated our analysis filtering the data at different minimum tree-size thresholds in order to find the effect this threshold has on our results. Lastly, we used empirical species–individual relationships (SIRs) to test the pre-existing hypothesis that environmental filtering is the primary cause of differences between the assemblage of saplings and that of adults on BCI. Important Findings Our age-structured neutral model was characterized by SARs that were insensitive to the presence of saplings at large scales and highly sensitive to them at small scales. Both models without age structure were highly sensitive to the DBH threshold chosen in a way that could not be explained based on random samplings alone. The age-structured neutral model, which allowed for non-random sampling based on life stage, was consistent with species richness observations. Our analysis of empirical SIRs did not support environmental filtering as a dominant force, but it did show evidence for other differences between age classes. Age can now be easily incorporated into future studies of neutral models whenever there is a concern that a sample is not entirely composed of reproductive adult individuals. More generally, we suggest that modeling studies using tree data subject to a minimum size threshold should consider the sensitivity of their results to that threshold.
Estrous cycle stage-dependent manner of type I interferon-stimulated genes induction in the bovine endometrium

Interferon tau (IFN-τ) is a ruminant-specific type I IFN secreted by a conceptus before its attachment to the uterus. IFN-τ induces the expression of IFN-stimulated genes (ISGs) via the type I IFN receptor (IFNAR), which is composed of IFNAR1 and IFNAR2 subunits in the endometrium. However, expression patterns of IFNARs during the estrous cycle have not been reported. We hypothesized that the response to a type I IFN changes along with IFNARs and the IFN-regulatory factors (IRFs) driving transcription of IFN signal-related genes and modulating a type I IFN signal during the estrous cycle. We investigated the estrous cycle stage-dependent type I IFN induction of ISGs and expression patterns of IFN signal-related genes in bovine endometrial tissues. Endometrial tissue pieces collected from bovine uteri at each estrous stage (early, mid, and late) were cultured with or without recombinant bovine IFN-α or concentrated pregnant uterine flushing (PUF) on day 18 after confirming the presence of a conceptus. IFN-α and PUF each significantly increased the expression of ISGs in endometrial tissues. The induction levels of the typical ISGs (MX1-a and ISG15) were significantly higher at the mid stage and correlated with high expression of IRFs at the mid stage. The immunostaining of IFNARs showed strong fluorescence intensities in luminal and glandular epithelia at the early and mid stages. Collectively, these results suggest that the endometrium exhibits estrous cycle stage-dependent responsiveness to type I IFN that may be associated with the expression of IFNARs and IRFs for pregnancy recognition.
Combining finite element method and Fourier transform to analyze waveguide transients

A numerical technique combining the finite element method (FEM) and Fourier transform is applied to calculate transients on 3-D microwave waveguide structures. The structures are modeled using a higher order FEM that can efficiently render frequency-domain responses at a large number of frequency samples, which are processed by the inverse discrete Fourier transform (IDFT) to obtain time-domain solutions. The FEM-IDFT approach is illustrated and its numerical properties are discussed in detail in the transient analysis of an E-plane ridge waveguide discontinuity.
Replication of Heterochromatin and Structure of Polytene Chromosomes

ABSTRACT Heterochromatin is characteristically the last portion of the genome to be replicated. In polytene cells, heterochromatic sequences are underreplicated because S phase ends before replication of heterochromatin is completed. Truncated heterochromatic DNAs have been identified in polytene cells of Drosophila and may be the discontinuous molecules that form between fully replicated euchromatic and underreplicated heterochromatic regions of the chromosome. In this report, we characterize the temporal pattern of heterochromatic DNA truncation during development of polytene cells. Underreplication occurred during the first polytene S phase, yet DNA truncation, which was found within heterochromatic sequences of all fourDrosophila chromosomes, did not occur until the second polytene S phase. DNA truncation was correlated with underreplication, since increasing the replication of satellite sequences with thecycE1672 mutation caused decreased production of truncated DNAs. Finally, truncation of heterochromatic DNAs was neither quantitatively nor qualitatively affected by modifiers of position effect variegation including the Y chromosome,Su(var)2052, parental origin, or temperature. We propose that heterochromatic satellite sequences present a barrier to DNA replication and that replication forks that transiently stall at such barriers in late S phase of diploid cells are left unresolved in the shortened S phase of polytene cells. DNA truncation then occurs in the second polytene S phase, when new replication forks extend to the position of forks left unresolved in the first polytene S phase.
The Effects of Training on Own and Co�?Worker Productivity: Evidence from a Field Experiment

This paper analyses the effects of work-related training on worker productivity. To identify the causal effects from training, we combine a field experiment that randomly assigns workers to treatment and control groups with panel data on individual worker performance before and after training. We find that participation in the training programme leads to a 10 percent increase in performance. Moreover, we provide experimental evidence for externalities from treated workers on their untreated teammates: An increase of 10 percentage points in the share of treated peers leads to a performance increase of 0.51 percent. We provide evidence that the estimated effects are causal and not the result of employee selection into and out of training. Furthermore, we find that the performance increase is not due to lower quality provided by the worker.
Lines of Thought: Central Concepts in Cognitive Psychology

Lines of Thought addresses how we are able to think about abstract possibilities: How can we think about math, despite the immateriality of numbers, sets, and other mathematical entities? How are we able to think about what might have happened if history had taken a different turn? Questions like these turn up in nearly every part of cognitive science, and they are central to our human position of having only limited knowledge concerning what is or might be true. Because we cannot experience hypothetical or future events or abstract concepts, we cannot use our ordinary sense of perception or memory to think about these subjects, so what underlies our ability to make these assumptions? Lance Rips explores people's beliefs about possibilities as they arise in the context of basic concepts, including numbers, causality, and reasons. He argues that beliefs about these concepts cannot be meaningfully reduced to perceptual information, remembered instances, or probabilities. He also claims that analogies to cognitive perception models are equally unhelpful in understanding what makes thinking of possibilities possible. Instead, he makes the case that our abilities here depend on the intrinsic hardwiring of the human mind. Lines of Thought provides an overview and a point of view on research in higher-level cognitive science, integrating theories from psychology, philosophy, and linguistics. The book is written in an accessible style that will provide students with essential background for their own thoughts about this domain.
Prognostic significance of vascular endothelial growth factor protein in node-negative breast carcinoma.

BACKGROUND The clinical outcome is generally positive for patients with node-negative breast carcinoma (i.e., those who do not have detectable metastases in the lymph nodes) who have been treated with surgery or surgery plus radiation therapy. In about 30% of the patients, however, the disease recurs, and they are at risk of death. Determination of valid new prognostic indicators would improve the ability to identify patients at high risk of recurrence. Breast cancer can entail substantial development of new blood vessels within the tumor tissue, and it is known that the growth and metastasis of solid tumors are dependent on such angiogenesis. The conversion of tumor cells to an angiogenic phenotype may be preceded by a change in the balance of angiogenic growth factors and angiogenesis inhibitors. PURPOSE This study was conducted to determine if the levels of vascular endothelial growth factor (VEGF) protein, a potent endothelial growth factor and mediator of vascular permeability and angiogenesis, measured in the primary tumors of women with node-negative breast cancer are associated with known prognostic factors and patient survival. METHODS By use of a selective enzymatic immunoassay, levels of VEGF protein were measured in cytosolic extracts of primary tumor tissue surgically obtained from 260 women with node-negative breast carcinoma who had been treated with surgery with or without radiation therapy but not with adjuvant therapy and who had been followed for a median time of 66 months. The relationships between VEGF concentrations and other prognostic dichotomous variables or clinical outcome were tested by the use of the Kolmogorov-Smirnov test and univariate and multivariate Cox analyses, respectively. The relationship between VEGF and hormone receptors (i.e., those for estrogen and progesterone) was examined by the use of Spearman's correlation analyses. All P values resulted from the use of two-sided statistical tests. RESULTS Tumors from 247 (95%) of the 260 patients had detectable VEGF, ranging in concentration from 5.0 to 6523 pg/mg protein (median, 126.25 pg/mg protein). No statistically significant associations were found between VEGF and the other prognostic factors (e.g., age, menopausal status, histologic tumor type, tumor size, and hormone receptors) examined. Levels of VEGF were found to be prognostic for both relapse-free and overall survival in univariate and multivariate analyses (likelihood ratio tests; all four P values < .001). In the multivariate analysis, the first-order interaction term of VEGF and estrogen receptor was also prognostic for overall survival (likelihood ratio test; P = .05). CONCLUSIONS The results show that cytosolic levels of VEGF in tumor tissue samples are indicative of prognosis for patients with node-negative breast carcinoma.
Learning and Forecasting Opinion Dynamics in Social Networks

Social media and social networking sites have become a global pinboard for exposition and discussion of news, topics, and ideas, where social media users often update their opinions about a particular topic by learning from the opinions shared by their friends. In this context, can we learn a data-driven model of opinion dynamics that is able to accurately forecast opinions from users? In this paper, we introduce SLANT, a probabilistic modeling framework of opinion dynamics, which represents users opinions over time by means of marked jump diffusion stochastic differential equations, and allows for efficient model simulation and parameter estimation from historical fine grained event data. We then leverage our framework to derive a set of efficient predictive formulas for opinion forecasting and identify conditions under which opinions converge to a steady state. Experiments on data gathered from Twitter show that our model provides a good fit to the data and our formulas achieve more accurate forecasting than alternatives.
Body-part-specific Representations of Semantic Noun Categories

Word meaning processing in the brain involves ventrolateral temporal cortex, but a semantic contribution of the dorsal stream, especially frontocentral sensorimotor areas, has been controversial. We here examine brain activation during passive reading of object-related nouns from different semantic categories, notably animal, food, and tool words, matched for a range of psycholinguistic features. Results show ventral stream activation in temporal cortex along with category-specific activation patterns in both ventral and dorsal streams, including sensorimotor systems and adjacent pFC. Precentral activation reflected action-related semantic features of the word categories. Cortical regions implicated in mouth and face movements were sparked by food words, and hand area activation was seen for tool words, consistent with the actions implicated by the objects the words are used to speak about. Furthermore, tool words specifically activated the right cerebellum, and food words activated the left orbito-frontal and fusiform areas. We discuss our results in the context of category-specific semantic deficits in the processing of words and concepts, along with previous neuroimaging research, and conclude that specific dorsal and ventral areas in frontocentral and temporal cortex index visual and affective–emotional semantic attributes of object-related nouns and action-related affordances of their referent objects.
A confirmatory factor analysis of the Hospital Anxiety and Depression scale: comparing empirically and theoretically derived structures.

OBJECTIVES To compare the fit of various factor solutions for the Hospital Anxiety and Depression scale (HAD; Zigmond & Snaith, 1983). DESIGN A cross-sectional postal survey was used to collect the data from community-based participants in the West of Scotland Twenty-07 study. METHODS The HAD scale, a 14-item self-administered measure of anxiety and depression, was completed by 2547 participants from three age cohorts (aged approximately 18, 39 and 58 years). Using confirmatory factor analyses four models suggested by prior exploratory factor analyses were compared to a model derived from Clark and Watson's (1991) tripartite theory of anxiety and depression. RESULTS The model derived from the tripartite theory of anxiety and depression (with factors labelled negative affectivity, anhedonic depression and autonomic anxiety) produced the closest fit to the data. This model produced a good fit in all three cohorts although group comparisons suggested that there were variations in the strength of some factor loadings across the three age groups. A model that had a hierarchical arrangement of the three factors in the tripartite model was also produced. This model fit the data equally as well as did the 'flat' tripartite model. CONCLUSIONS Three factors appear to underlie the HAD scale. Research is needed that examines whether or not using sub-scales based on these factors increases the ability of the HAD scale to detect cases of anxiety and depression.
The nature of agricultural information needs of small scale farmers in Africa : the Nigerian example

Le developpement agricole, malgre le soutien des donateurs et des governements, n'a pas ete couronne de succes au Nigeria. Un accent particulier a ete mis sur l'approche de la transformation agricole a grande echelle, et peu d'attention a ete octroyee a la diffusion de l'information qui est un element cle dans les programmes de developpement agricole. Il existe une nouvelle approche en agriculture qui met plus l'accent sur les agriculteurs et les petites exploitations agricoles. Si cette nouvelle approche est satisfaisante, d'autres devraient etre prises dans le domaine de la diffusion et de la gestion de l'information, en se basant sur une meilleure comprehension des besoins en information au niveau des agriculteurs. La nature de la petite exploitation agricole ainsi que les besoins en information sont identifiees, et une etude est faite sur le processus actuel de la diffusion de l'information agricole. Les canaux de diffusion de cette information sont mentionnes, et leurs contraintes et points forts analyses. Des suggestions sont faites pour ameliorer le systeme actuel, entre autres l'utilisation de media traditionnel.
Susceptibility loci for atopic dermatitis on chromosome 21 in a Swedish population

Background: Atopic dermatitis (AD) is a hereditary, pruritic, chronic, relapsing, inflammatory skin disease resulting from multiplex interactions between genes and environmental factors. We have previously found several loci showing suggestive linkage on chromosomes 3q14, 13q14, 15q14‐15 and 17q21, and weaker linkage to chromosomes 1p32, 4q24‐26 and 21q21 in 109 Swedish families.