Miracle-dz/UniFAR-FTUs huggingface dataset:
Freud Scientifically Reappraised: Testing the Theories and Therapy

What Is Psychoanalytic Reality? THE THEORIES. Freud's Understanding of Psychopathology: The Depression Formulation. The Paranoid Formulation. The Oral Paradigm. The Anal Paradigm. Oedipal Concatenations. The Dream Theory: Camouflage and Venting. THE THERAPY. Evaluating Psychoanalytic Therapy: Once More into the Abyss. Psychodynamic Treatment Ingredients: The Pursuit of Insight. INTEGRATION. A Pantoscopic View: Evaluation and Revision. References. Indexes.
Clinical Interventions in Aging Dovepress Correlation between Movement Complexity during Static Standing and Balance Function in Institutionalized Older Adults

hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms Purpose: Sample entropy (SampEn) is an analysis to evaluate movement complexity of the center of pressure (COP). A lower value of SampEn indicates lower complexity of COP variability , that is, rigidity, and lower degrees of freedom. Previous studies reported the association of increased SampEn with improved standing balance ability in young subjects. However, no studies have examined these relationships among older adults. Thus, we aimed to investigate the relationship between SampEn and standing balance ability in older adults. Subjects and methods: The subjects were 33 institutionalized older adults (aged 82.2±6.5 years). COP during static standing was measured. The standard deviation (SD) values of COP and SampEn in the sagittal and frontal planes were calculated using time series data. One-leg standing test (OLST), functional reach (FR) test, and lateral reach (LR) test were also measured to evaluate standing balance ability. Pearson correlation analysis revealed that SampEn in the sagittal plane significantly correlated with OLST (r=-0.35) and FR (r=-0.36). However, SampEn in the frontal plane and SD of COP in both sagittal and frontal planes had no relationship with any of the clinical balance tests. Conclusion: Lower SampEn implies rigidity for postural control. In the present study, it was found that lower SampEn in the sagittal plane was related to a higher balance function, which suggests that older adults utilized body rigidity to maintain postural stability as a compensative strategy.
Long-Term Effects of Neonatal Exposure to Hydroxylated Polychlorinated Biphenyls in the BALB/cCrgl Mouse

The neonatal mouse model has been a valuable tool in determining the long-term effects of early exposure to estrogenic agents in mammals. Using this model, we compared the effects of 2′,4′,6′-trichloro-4-biphenylol (OH-PCB-30) and 2′,3′,4′,5′-tetrachloro-4-biphenylol (OH-PCB-61) as prototype estrogenic hydroxylated PCBs (OH-PCBs) because they are reported to exhibit relatively high estrogenic activity both in vivo and in vitro. The purpose of this study was to examine the relationship between estrogenicity and carcinogenicity of OH-PCB congeners. The OH-PCBs were tested individually and in combination to determine whether effects of combined OH-PCBs differed from those of these OH-PCBs alone. We evaluated the long-term effects of neonatal exposure to OH-PCBs with treatment doses that were based on the reported binding affinity of specific OH-PCB congeners to estrogen receptor α. BALB/cCrgl female mice were treated within 16 hr after birth by subcutaneous injections every 24 hr, for 5 days. The mice treated with OH-PCB-30 (200 μg/day) or 17β-estradiol (5 μg/day) showed similar increased incidences of cervicovaginal (CV) tract carcinomas (43% and 47%, respectively). In addition, when mice were treated with OH-PCBs as a mixture, a change in the type of CV tract tumor was observed, shifting from predominantly squamous cell carcinomas to adenosquamous cell carcinoma. From our results, we conclude that the individual OH-PCBs tested were estrogenic and tumorigenic in mice when exposed during development of the reproductive tract. These data support the hypothesis that mixtures may act differently and unexpectedly than do individual compounds.
Synergistic Anti-Inflammatory Activity of the Antimicrobial Peptides Human Beta-Defensin-3 (hBD-3) and Cathelicidin (LL-37) in a Three-Dimensional Co-Culture Model of Gingival Epithelial Cells and Fibroblasts

Given the spread of antibiotic resistance in bacterial pathogens, antimicrobial peptides that can also modulate the immune response may be a novel approach for effectively controlling periodontal infections. In the present study, we used a three-dimensional (3D) co-culture model of gingival epithelial cells and fibroblasts stimulated with Aggregatibacter actinomycetemcomitans lipopolysaccharide (LPS) to investigate the anti-inflammatory properties of human beta-defensin-3 (hBD-3) and cathelicidin (LL-37) and to determine whether these antimicrobial peptides can act in synergy. The 3D co-culture model composed of gingival fibroblasts embedded in a collagen matrix overlaid with gingival epithelial cells had a synergistic effect with respect to the secretion of IL-6 and IL-8 in response to LPS stimulation compared to fibroblasts and epithelial cells alone. The 3D co-culture model was stimulated with non-cytotoxic concentrations of hBD-3 (10 and 20 µM) and LL-37 (0.1 and 0.2 µM) individually and in combination in the presence of A. actinomycetemcomitans LPS. A multiplex ELISA assay was used to quantify the secretion of 41 different cytokines. hBD-3 and LL-37 acted in synergy to reduce the secretion of GRO-alpha, G-CSF, IP-10, IL-6, and MCP-1, but only had an additive effect on reducing the secretion of IL-8 in response to A. actinomycetemcomitans LPS stimulation. The present study showed that hBD-3 acted in synergy with LL-37 to reduce the secretion of cytokines by an LPS-stimulated 3D model of gingival mucosa. This combination of antimicrobial peptides thus shows promising potential as an adjunctive therapy for treating inflammatory periodontitis.
Transfer of spontaneously hatching or hatched blastocyst yields better pregnancy rates than expanded blastocyst transfer

CONTEXT: Blastocyst stage embryo transfer (ET) has become routine practice in recent years. However, probably due to limitations of assisted hatching techniques, expanded blastocyst transfer (EBT) is still the preferred mode. Inexplicably, not much consideration has been given to spontaneously hatching/hatched blastocyst transfer (SHBT). AIM: This study aimed to investigate developmental potential of spontaneously hatching/hatched blastocyst against EBT in in vitro fertilization (IVF) cycles. SETTINGS AND DESIGN: Prospective study of 146 women undergoing their first IVF- ET cycle. SUBJECTS AND METHODS: On the basis of blastocyst status, women were classified into SHBT and EBT groups. Intracytoplasmic sperm injection cycles were excluded to remove male factor bias. Implantation rate (IR), clinical pregnancy rate, and live birth rate were the main outcome measures. STATISTICAL ANALYSIS: Graph-pad Prism 5 statistical package. RESULTS: SHBT group showed significantly higher blastocyst formation rate (53.3 ± 17.5 vs. 43.1 ± 14.5%, P = 0.0098), top-quality blastocysts (71.8 vs. 53.7%, P = 0.0436), IR (43.6 vs. 27.9%, P = 0.0408), pregnancy rate (59.4 vs. 45.1%, P = 0.0173), and live birth rate (36.8 vs. 22.8%, P = 0.003) compared to EBT group. Multiple pregnancy rates remained comparable between the two groups. Implantation correlated strongly with top-quality blastocysts (Pearson, r = 0.4441) in SHBT group, while the correlation was nonsignificant in EBT group. CONCLUSION: Extending culture of expanded blastocysts by a few hours to allow transfer of spontaneously hatching/hatched blastocysts gives higher implantation and pregnancy rates with no added risk of multiple gestations. Spontaneously hatching/hatched blastocysts have a better potential to implant and develop into a positive pregnancy.
Modified Lee Plate Equations for the Vibration Analysis of Piezoelectric Plates with Consideration of Stiffness and Mass of Electrodes

Lee plate equations for high frequency vibrations of piezoelectric plates have been established and improved over the decades with the sole objective to obtain the accurate prediction of frequency and mode shapes to aid crystal resonator design. The latest improvement includes extra terms related to derivatives of the flexural displacement to adjust the accuracy and for the consideration of the electrode for practical applications. As part of the efforts to make the equations more practical for resonator design with the improved of frequency accuracy and consideration of electrodes, the authors derived Lee plate equations for electroded plates by changing the integration limits in the dimension reduction procedure to signify the dominant role of the crystal plate. As a result, the equations are modified for the inclusion of the electrode effects. To improve the accuracy in the vicinity of thickness-shear vibration frequency of electroded plates, we modified the density terms in plate equations to reflect the contribution of both electrode stiffness and density, which makes the frequency more accurate for commonly used electrode materials
Barriers and facilitators to HIV testing and linkage to primary care: narratives of people with advanced HIV in the Southeast

Abstract Persons with unrecognized HIV infection forgo timely clinical intervention and may unknowingly transmit HIV to partners. However, in the USA, unrecognized infection and late diagnosis are common. To understand barriers and facilitators to HIV testing and care, we conducted a qualitative study of 24 HIV infected persons attending a Southeastern HIV clinic who presented with clinically advanced illness. The primary barrier to HIV testing prior to diagnosis was perception of risk; consequently, most participants were diagnosed after the onset of clinical symptoms. While most patients were anxious to initiate care rapidly after diagnosis, some felt frustrated by the passive process of connecting to specialty care. The first visit with an HIV care provider was identified as critical in the coping process for many patients. Implications for the implementation of Centers for Disease Control and Prevention HIV routine screening guidelines are discussed.
Osteocytic Expression of Constitutive NO Synthase Isoforms in the Femoral Neck Cortex: A Case‐Control Study of Intracapsular Hip Fracture

NO is an osteocytic signaling molecule that can inhibit osteoclasts. The NO synthases eNOS and nNOS were expressed by >50% of osteonal osteocytes in controls. Hip fracture cases showed +NOS osteocytes only in deep osteonal bone, and 25–35% reduced expression overall. These data are consistent with increased osteonal vulnerability to deep osteoclastic attack.
Tuberculous tenosynovitis and bursitis: imaging findings in 21 cases.

PURPOSE To describe imaging features of tuberculous tenosynovitis and bursitis with various imaging methods. MATERIALS AND METHODS Twenty-one patients with surgically and/or pathologically proved tuberculosis of the tendon sheaths or bursae were evaluated. Routine radiography, arthrography, computed tomography (CT), and magnetic resonance (MR) imaging were used in some or all of the patients. RESULTS Twelve patients had tuberculous tenosynovitis, and nine had bursitis. Tuberculous tenosynovitis most commonly involved the tendon sheaths of the hand and wrist, whereas bursitis occurred most frequently about the hip, especially in the trochanteric bursa. All cases of tuberculous tenosynovitis or bursitis showed soft-tissue swelling on plain radiographs, with calcification demonstrated in three of nine (33%) cases. CT and MR imaging allowed evaluation of all forms of tuberculous tenosynovitis (hygromatous, serofibrinous, and fungoid forms), whereas tuberculous bursitis exhibited two patterns of involvement: either a distended bursa or multiple small abscesses. Contrast material-enhanced radiography (i.e., arthrography) helped delineate communication between the affected structures. CONCLUSION All imaging methods can provide complementary information that is helpful for determination of therapy. MR imaging seems to be superior in evaluating the extent of the lesion, particularly in soft tissue.
The origin, source, and cycling of methane in deep crystalline rock biosphere

The emerging interest in using stable bedrock formations for industrial purposes, e.g., nuclear waste disposal, has increased the need for understanding microbiological and geochemical processes in deep crystalline rock environments, including the carbon cycle. Considering the origin and evolution of life on Earth, these environments may also serve as windows to the past. Various geological, chemical, and biological processes can influence the deep carbon cycle. Conditions of CH4 formation, available substrates and time scales can be drastically different from surface environments. This paper reviews the origin, source, and cycling of methane in deep terrestrial crystalline bedrock with an emphasis on microbiology. In addition to potential formation pathways of CH4, microbial consumption of CH4 is also discussed. Recent studies on the origin of CH4 in continental bedrock environments have shown that the traditional separation of biotic and abiotic CH4 by the isotopic composition can be misleading in substrate-limited environments, such as the deep crystalline bedrock. Despite of similarities between Precambrian continental sites in Fennoscandia, South Africa and North America, where deep methane cycling has been studied, common physicochemical properties which could explain the variation in the amount of CH4 and presence or absence of CH4 cycling microbes were not found. However, based on their preferred carbon metabolism, methanogenic microbes appeared to have similar spatial distribution among the different sites.
A Review of the Validity and Reliability of Alcohol Retail Sales Data for Monitoring Population Levels of Alcohol Consumption: A Scottish Perspective

Aims: To assess the validity and reliability of using alcohol retail sales data to measure and monitor population levels of alcohol consumption. Methods: Potential sources of bias that could lead to under- or overestimation of population alcohol consumption based on alcohol retail sales data were identified and, where possible, quantified. This enabled an assessment of the potential impact of each bias on alcohol consumption estimates in Scotland. Results: Overall, considering all the possible sources of overestimation and underestimation, and taking into account the potential for sampling variability to impact on the results, the range of uncertainty of consumption during 2010 was from an overestimate of 0.3 l to an underestimate of 2.4 l of pure alcohol per adult. This excludes the impacts of alcohol stockpiling and alcohol sold through outlets not included in the sampling frame. On balance, there is therefore far greater scope for alcohol retail sales data to be underestimating per adult alcohol consumption in Scotland than there is for overestimation. Conclusion: Alcohol retail sales data offer a robust source of data for monitoring per adult alcohol consumption in Scotland. Consideration of the sources of bias and a comprehensive understanding of data collection methods are essential for using sales data to monitor trends in alcohol consumption.
In Thought, Word, and Deed: Suicidal Behaviors of Adjudicated Youth

This study examines suicide ideation, plans, and attempts by youth in two juvenile justice settings: incarcerated youth (n = 83) and youth with community service sentences (n = 144). The incarcerated sample reported 51% suicide ideation while the community sample reported 22%. For both samples, suicide contemplators were quite likely (60-70%) to have a suicide plan, while about 35% reported a suicide attempt in the past 12 months. Contemplators were distinguishable from noncontemplators on scores for external problems of delinquency and aggression, internal problems of anxiety, depression, withdrawal and somatic complaints, general depression, and general health status. The results have implications for assessment, triage, and brief treatment in juvenile justice settings. Language: en
Consequences of Childhood Sexual Abuse for College Students.

A survey of university undergraduates (n = 958) disclosed that over 4% recall being forced into oral or genital sexual abuse during their childhood Survivors reported minimal evidence Of emotional or family dysfunction. However they behaved promiscuously, attempted suicide, perpetrated sexual assault and engaged in juvenile crimes. These findings were relatively consistent across gender and levels of parental education.
Usos, gestos y vocalizaciones privadas: de la interacción social a la autorregulación

Resumen El papel del lenguaje en la autorregulación ha sido ampliamente estudiado. Sin embargo, hay escasa evidencia sobre la función de autorregulación de los sistemas semióticos prelingüísticos en el desarrollo temprano. Presentamos un estudio de diseño longitudinal para explorar cuándo y cómo los niños/as comienzan a utilizar signos prelingüísticos con una función de autorregulación. Observamos a cuatro bebés en interacción con un adulto y un objeto complejo, a los 11, 13 y 15 meses de edad. Se condujo un análisis microgenético de las observaciones desde una perspectiva semiótica y pragmática del desarrollo y del objeto (Rodríguez y Moro, 1999). Los niños utilizaron distintos signos prelingüísticos privados para autorregular su acción al usar los objetos y/o instrumentos (ostensivos sin instrumento, con instrumento, vocalizaciones de acompañamiento de la acción y evaluadoras). Se describen las categorías utilizadas para caracterizar estos comportamientos y se analizan observaciones que las ilustran.
Grain Size Control of Tetragonal Zirconia Polycrystals Using the Space Charge Concept

Grain growth kinetics and grain-boundary segregation of 12Ce-TZP and 2Y-TZg containing divalent to pentavalent cationic dopants, were studied. In all cases, normal grain growth following the parabolic growth relation was observed at higher temperatures. The mobility of grain boundaries was suppressed by the addition of divalent and trivalent cations, unchanged or enhanced by the addition of tetravalent and pentavalent cations. Larger cations have a stronger effect in suppressing grain growth. From ESCA, AES, and STEM analysis of the near grain-boundary regions, it is further concluded that only divalent and trivalent cations segregate. These observations can be satisfactorily rationalized using the space charge concept and the model of impurity drag. [Key words: grain growth, tetragonal zircoda polycrystals, segregation, grain boundaries, dopants. ]
Fitness of ALS-Inhibitors Herbicide Resistant Population of Loose Silky Bentgrass (Apera spica-venti)

Herbicide resistance is an example of plant evolution caused by an increased reliance on herbicides with few sites of action to manage weed populations. This micro-evolutionary process depends on fitness, therefore the assessment of fitness differences between susceptible and resistant populations are pivotal to establish management strategies. Loose silky bentgrass (Apera spica-venti) is a serious weed in Eastern, Northern, and Central Europe with an increasing number of herbicide resistant populations. This study examined the fitness and growth characteristics of an ALS resistant biotype. Fitness and growth characteristics were estimated by comparing seed germination, biomass, seed yield and time to key growth stages at four crop densities of winter wheat (0, 48, 96, and 192 plants m-2) in a target-neighborhood design. The resistant population germinated 9–20 growing degree days (GDD) earlier than the susceptible population at 10, 16, and 22°C. No differences were observed between resistant and susceptible populations in tiller number, biomass, time to stem elongation, time to first visible inflorescence and seed production. The resistant population reached the inflorescence emergence and flowering stages in less time by 383 and 196 GDD, respectively, at a crop density of 96 winter wheat plants m-2 with no differences registered at other densities. This study did not observe a fitness cost to herbicide resistance, as often hypothesized. Inversely, a correlation between non-target site resistance (NTSR), earlier germination and earlier flowering time which could be interpreted as fitness benefits as these plant characteristics could be exploited by modifying the timing and site of action of herbicide application to better control ALS NTSR populations of A. spica-venti.
Current status of and strategies for hepatitis C control in South Korea

Chronic hepatitis C (CHC) is caused by hepatitis C virus (HCV) infection. HCV infection causes acute hepatitis, and the majority of those infected progress to chronic hepatitis, and some of them develop cirrhosis and hepatocellular carcinoma. Transmission of HCV is parenteral, and the major transmission routes include drug abuse, insecure injections or medical procedures, contaminated syringes or needles, sexual contact with an HCV-infected person, vertical infection of newborns by infected mothers, the transfusion of blood or blood products contaminated with viruses, and organ transplants. As no vaccine against HCV is available, HCV management involves blocking routes of transmission transmission, screening for HCV infection, and protecting liver disease progression by treatment. Highly potent oral direct antiviral agents are now available. Therefore, early detection through nation-wide screening program and appropriate treatment should be implemented to improve the quality of life of patients with HCV. Furthermore, for the effective HCV control in South Korea, The organization of an ‘integrated national viral hepatitis control system’ is desirable.