Miracle-dz/UniFAR-FTUs huggingface dataset:
Reference range of zinc in adult population (20-29 years) of Lahore, Pakistan

Objective: To determine the reference range of zinc in adult population (age range 20 to 29 years) of Lahore. Methods: It was a descriptive cross sectional study which was carried out from Jan- August 2012 in Chemical Pathology Department of University of Health Sciences, Lahore. Serum zinc concentration was measured by flame atomic absorption spectrometry in randomly selected 450 healthy adults aged 20 to 29 years. After application of exclusion criteria reference values were determined in apparently healthy subjects according to guidelines of International Federation of Clinical Chemistry. The data was entered & analyzed using SPSS version 20.0. Serum Zn levels was expressed as Mean ± SD. Results: A total of 450 healthy subjects were included in this study. Out of these, 234 were females. Mean age was 25±0.13years. The mean concentration of zinc in serum of healthy individual was 24.02±7.03 µmol/L (range11.47-36.72). The mean±SD for males subjects were 22.33±6.42 µmol/L(range11.93-32.4). Similarly the mean±SD for females were 21.72±7.34 µmol/L (range9.94-36.87). Conclusion: This study presents reference range for serum zinc concentration in adult population of Lahore. The results showed that there is significant difference in serum level of zinc among different countries. This study will help us in establishing reference ranges of trace elements on larger population in future.
Experiences of sexual relationships of young black women in an atmosphere of coercion

Negotiations surrounding sexual activity are characterised by multiple power disparities that include race, social status and age, with gender being the most dominant differential in heterosexual interactions. Research has shown that women are physiologically more at risk of contracting HIV than men, as indicated by the higher infection rates of the former. Many African societies operate via a hegemonic masculinity, with patriarchal governance and female subordination being the norm, placing women at even greater risk of HIV infection. In this qualitative phenomenological study, four black school-going adolescent women living in Grahamstown were interviewed using a semi-structured interview to gather data. An interpretative phenomenological analysis was conducted on the data to provide subjective insights of the experiences of the participants with regard to their interactions with men. From the findings, it became apparent that the participants felt pressured, coerced or manipulated by male counterparts. This pressure and coercion was not just felt in their interactions with older men, but also in their romantic partnerships. Three of the participants experienced pressure to engage in sexual intercourse with their boyfriends when they were unwilling or unready, and they reported being faced with additional pressure to engage in unprotected sex. Furthermore, it became apparent that each participant had an underlying fear of being raped and considered this as a genuine threat to her safety and sexual health. The atmosphere within which these participants negotiate their sexual agency is thus heavily informed by male control, coercion and the threat of violence or rape.
Cross-species complementation of the indispensable Escherichia coli era gene highlights amino acid regions essential for activity

Era is an essential GTP binding protein in Escherichia coli. Two homologs of this protein, Sgp from Streptococcus mutans and Era from Coxiella burnetii, can substitute for the essential function of Era in E. coli. Site-specific and randomly generated Era mutants which may indicate regions of the protein that are of functional importance are described.
A proposed RTL design technique for highly optimized on-chip data processors of MEMS sensors

Semiconductor sensor systems based on specific MEMS structures usually have to comprise at least a robust on-chip analogue read-out circuitry making it possible to detect and post-process the changes in physical characteristics. In order to ensure mobility or to improve reliability, robustness and performance (speed and/or power-consumption) the subsequent parts of the post-processing circuitry, namely the digital data processor or certain parts of it may also be implemented on-chip. Integration and cost usually treated as main objectives in both analogue and digital designs become essential when the data-processing subsystem has to be fit in a very limited area close to a MEMS sensor structure. The paper presents a novel Register-Transfer Level (RTL) design method aiming optimized design of digital data-processing systems related to MEMS sensors' post-processing algorithms. The paper presents a novel RTL description language and a unique synthesis flow resulting in area-optimized gate-level implementations capable of fulfilling the strict requirements set by the MEMS-based sensor environment.
SATELLITE DWARF GALAXIES IN A HIERARCHICAL UNIVERSE: INFALL HISTORIES, GROUP PREPROCESSING, AND REIONIZATION

In the Local Group (LG), almost all satellite dwarf galaxies that are within the virial radius of the Milky Way (MW) and Andromeda (M31) exhibit strong environmental influence. The orbital histories of these satellites provide the key to understanding the role of the MW/M31 halo, lower-mass groups, and cosmic reionization on the evolution of dwarf galaxies. We examine the virial-infall histories of satellites with M star = 10 3 − 9 M ⊙ ? > using the Exploring the Local Volume in Simulations suite of cosmological zoom-in dissipationless simulations of 48 MW/M31-like halos. Satellites at z = 0 fell into the MW/M31 halos typically 5 − 8 Gyr ? > ago at z = 0.5 − 1 ? > . However, they first fell into any host halo typically 7 − 10 Gyr ? > ago at z = 0.7 − 1.5 ? > . This difference arises because many satellites experienced “group preprocessing” in another host halo, typically of M vir ∼ 10 10 − 12 M ⊙ ? > , before falling into the MW/M31 halos. Satellites with lower mass and/or those closer to the MW/M31 fell in earlier and are more likely to have experienced group preprocessing; half of all satellites with M star < 10 6 M ⊙ ? > were preprocessed in a group. Infalling groups also drive most satellite–satellite mergers within the MW/M31 halos. Finally, none of the surviving satellites at z = 0 were within the virial radius of their MW/M31 halo during reionization ( z > 6 ? > ), and only < 4 % ? > were satellites of any other host halo during reionization. Thus, effects of cosmic reionization versus host-halo environment on the formation histories of surviving dwarf galaxies in the LG occurred at distinct epochs, separated typically by 2 − 4 Gyr ? > , so they are separable theoretically and, in principle, observationally.
Stochastic Acceleration of Low-Energy Electrons in Cold Plasmas

We investigate the possibility of stochastic acceleration of background low-energy electrons by turbulent plasma waves. We consider the resonant interaction of the charged particles with all branches of the transverse plasma waves propagating parallel to a uniform magnetic field. Numerical results and asymptotic analytic solutions valid at nonrelativistic and ultrarelativistic energies are obtained for the acceleration and scattering times of electrons. These times have a strong dependence on plasma parameter α = ωpe/Ωe (the ratio of electron plasma frequency to electron gyrofrequency) and on the spectral index of plasma turbulence. It is shown that particles with energies above a certain critical value may interact with higher frequency electromagnetic plasma waves, and this interaction is allowed only in plasmas with α < 1. We show that for nonrelativistic and semirelativistic electrons in low-α plasmas, the ratio of the acceleration time to the scattering time can be less than unity for a wide range of energies. From this we conclude that the transport equation derived for cosmic rays that requires this ratio to be much larger than unity is not applicable at these energies. An approximate “critical” value of particle energy above which the dynamics of charged particles may be described by this transport equation is determined as a function of plasma parameters. We propose new transport equation for the opposite limit (energies less than this critical value) when the acceleration rate is much faster than the pitch angle scattering rate. This equation is needed to describe the electron dynamics in plasmas with α ≲ 0.1.
Heat Stress Modulates Both Anabolic and Catabolic Signaling Pathways Preventing Dexamethasone‐Induced Muscle Atrophy In Vitro

It is generally recognized that synthetic glucocorticoids induce skeletal muscle weakness, and endogenous glucocorticoid levels increase in patients with muscle atrophy. It is reported that heat stress attenuates glucocorticoid‐induced muscle atrophy; however, the mechanisms involved are unknown. Therefore, we examined the mechanisms underlying the effects of heat stress against glucocorticoid‐induced muscle atrophy using C2C12 myotubes in vitro, focusing on expression of key molecules and signaling pathways involved in regulating protein synthesis and degradation. The synthetic glucocorticoid dexamethasone decreased myotube diameter and protein content, and heat stress prevented the morphological and biochemical glucocorticoid effects. Heat stress also attenuated increases in mRNAs of regulated in development and DNA damage responses 1 (REDD1) and Kruppel‐like factor 15 (KLF15). Heat stress recovered the dexamethasone‐induced inhibition of PI3K/Akt signaling. These data suggest that changes in anabolic and catabolic signals are involved in heat stress‐induced protection against glucocorticoid‐induced muscle atrophy. These results have a potentially broad clinical impact because elevated glucocorticoid levels are implicated in a wide range of diseases associated with muscle wasting. J. Cell. Physiol. 232: 650–664, 2017. © 2016 The Authors. Journal of Cellular Physiology published by Wiley Periodicals, Inc.
Long-term risk of second malignancy in survivors of Hodgkin's disease treated during adolescence or young adulthood.

PURPOSE To quantify the long-term risk of second primary cancers (SCs) in patients diagnosed with Hodgkin's disease (HD) during adolescence or young adulthood. PATIENTS AND METHODS The risk of SCs was assessed in 1,253 patients diagnosed with HD before the age of 40 years and treated in two Dutch cancer centers between 1966 and 1986. The median follow-up duration was 14.1 years. RESULTS In all, 137 patients developed SCs, compared with 19.4 cases expected on the basis of incidence rates in the general population (relative risk [RR] = 7.0; 95% confidence interval, 5.9 to 8.3). The 25-year actuarial risk of SC overall was 27.7%. The RR of solid tumors increased greatly with younger age at the first treatment of HD, not only for breast cancer but also for all other solid tumors, with RRs of 4.9, 6.9, and 12.7 for patients first treated at ages 31 to 39 years, 21 to 30 years, and </= 20 years, respectively. Among patients first treated at the age of 20 years or younger, the RR of developing a solid tumor before the age of 40 years was significantly greater than the RR of solid tumor development at ages 40 to 49 years (RR = 27.9 v RR = 4.2; P =.0001). Patients who received salvage chemotherapy had significantly greater risk of solid cancers other than breast cancer than did patients whose treatment was restricted to initial radiotherapy or initial combined-modality treatment (RR = 9.4 and 4.7, respectively; P =. 004). CONCLUSION After more than 20 years of follow-up, the risk of solid tumors is still much greater in survivors of HD than in the population at large. Reassuringly, the greatly increased risk of solid tumors in patients who were young (</= 20 years of age) at the first treatment seems to decrease as these patients grow older. Our data suggest that chemotherapy may increase the risk of solid tumors from radiotherapy.
Influence of Dangling Ends and Surface-Proximal Tails of Targets on Probe-Target Duplex Formation in 16S rRNA Gene-Based Diagnostic Arrays

ABSTRACT Dangling ends and surface-proximal tails of gene targets influence probe-target duplex formation and affect the signal intensity of probes on diagnostic microarrays. This phenomenon was evaluated using an oligonucleotide microarray containing 18-mer probes corresponding to the 16S rRNA genes of 10 waterborne pathogens and a number of synthetic and PCR-amplified gene targets. Signal intensities for Klenow/random primer-labeled 16S rRNA gene targets were dissimilar from those for 45-mer synthetic targets for nearly 73% of the probes tested. Klenow/random primer-labeled targets resulted in an interaction with a complex mixture of 16S rRNA genes (used as the background) 3.7 times higher than the interaction of 45-mer targets with the same mixture. A 7-base-long dangling end sequence with perfect homology to another single-stranded background DNA sequence was sufficient to produce a cross-hybridization signal that was as strong as the signal obtained by the probe-target duplex itself. Gibbs free energy between the target and a well-defined background was found to be a better indicator of hybridization signal intensity than the sequence or length of the dangling end alone. The dangling end (Gibbs free energy of −7.6 kcal/mol) was found to be significantly more prone to target-background interaction than the surface-proximal tail (Gibbs free energy of− 64.5 kcal/mol). This study underlines the need for careful target preparation and evaluation of signal intensities for diagnostic arrays using 16S rRNA and other gene targets due to the potential for target interaction with a complex background.
Direct Versus Indirect Measurement of Digit Ratio (2D:4D)

Digit ratio (2D:4D: the relative lengths of the second and fourth digits) is widely used as a correlate of prenatal sex steroids. There are two common methods of measuring 2D:4D, the direct method and the indirect method. The modern interest in 2D:4D began 16 years ago when finger lengths were measured directly, but many studies now report 2D:4D calculated from indirectly measured fingers from photocopies or scans. However, there are concerns about the accuracy of the latter in comparison to the former. The purpose of this article was twofold: to review these concerns and to add new data to the debate. Our review shows that in 2005, directional effects in indirect 2D:4D were reported such that direct 2D:4D > indirect 2D:4D. This finding was challenged by a 2006 report that direct 2D:4D was lower (not higher) than indirect 2D:4D for male right-hand 2D:4D. Two further studies from the same group have claimed that indirect 2D:4D may be lower, higher, or comparable to direct 2D:4D. More recent comparisons of direct 2D:4D versus indirect 2D:4D and a meta-analysis of Chinese studies have replicated the finding of direct 2D:4D > indirect 2D:4D. We considered an additional sample and found significant direct 2D:4D > indirect 2D:4D for three of four ratios. The overall literature is discussed within the context of standards of research (sample size) and publishing (clarity of report). It is concluded that direct 2D:4D does tend to be greater than indirect 2D:4D. Implications for comparative studies and other aspects of research in 2D:4D are discussed.
Tau directs intracellular trafficking by regulating the forces exerted by kinesin and dynein teams

Organelles, proteins, and mRNA are transported bidirectionally along microtubules by plus-end directed kinesin and minus-end directed dynein motors. Microtubules are decorated by microtubule-associated proteins (MAPs) that organize the cytoskeleton, regulate microtubule dynamics and modulate the interaction between motor proteins and microtubules to direct intracellular transport. Tau is a neuronal MAP that stabilizes axonal microtubules and crosslinks them into bundles. Dysregulation of tau leads to a range of neurodegenerative diseases known as tauopathies including Alzheimer’s disease (AD). Tau reduces the processivity of kinesin and dynein by acting as an obstacle on the microtubule. Single-molecule assays indicate that kinesin-1 is more strongly inhibited than kinesin-2 or dynein, suggesting tau might act to spatially modulate the activity of specific motors1-4. To investigate the role of tau in regulating bidirectional transport, we isolated phagosomes driven by kinesin-1, kinesin-2, and dynein and reconstituted their motility along microtubules5. We find that tau biases bidirectional motility towards the microtubule minus-end in a dose-dependent manner. Optical trapping measurements show that tau increases the magnitude and frequency of forces exerted by dynein through inhibiting opposing kinesin motors. Mathematical modeling indicates that tau controls the directional bias of intracellular cargoes through differentially tuning the processivity of kinesin-1, kinesin-2, and dynein. Taken together, these results demonstrate that tau modulates motility in a motor-specific manner to direct intracellular transport, and suggests that dysregulation of tau might contribute to neurodegeneration by disrupting the balance of plus- and minus-end directed transport.
Effects of high-intensity treadmill training on timeliness and plasticity expression of irisin in mice.

OBJECTIVE The purpose of this study was to investigate effects of high-intensity aerobic exercise training on timeliness and plasticity expression of irisin in mice and change of FNDC5, ACCβ expression, and to explore possible ways to influence its mechanism of fatty acid metabolism. MATERIALS AND METHODS Adult male mice of specific pathogen-free grade [Kunming mice, (20 ± 2) g] are randomly divided into 4 groups. Wherein the first group is immediately after one-time exercise groups: including control group (CN group 1), 0.5 h exercise group (group 2), 1 h exercise group (group 3), 1.5 h exercise group (group 4) and 2 h exercise group (group 5), each for 10. The second group is rest after one-time 60 min exercise groups: including control group (CN group 1), rest 20 min groups (groups 2), rest 40 min group (group 3), rest 60 min group (groups 4), rest 80 min group (group 5), each for 10. Third group is immediately after long-term exercise groups: including the control group (CN group 1), 0.5 h exercise group (group 2), 1 h exercise group (group 3), 1.5 h exercise group (group 4) and 2 h exercise group (group 5), each for 10. The fourth group is rest after long-term 60 min exercise group: including control group (CN group 1), rest 20 min group (group 2), rest 40 min group (group 3), rest 60 min group (4 groups) and rest 80 min groups (5 groups), each for 10. RESULTS With the extension of a one-time high-intensity exercise time, the mouse FNDC5 protein, P-ACCβ / ACCβ ratio showed fluctuations, and opposite trends between the two, its turning points are 1.5 h; FNDC5 protein and P-ACCβ / ACCβ ratio with long-term exercise in mice at different time produce adaptability; the regulation of exercise induced irisin timeliness and plasticity reflected after a long-term exercise irisin expression in serum showed a steady decline in trend and return to normal levels, compared to a one-time exercise, expression of irisin is more stable. CONCLUSIONS With the high-intensity exercise a one-time extension of time, the mouse FNDC5 proteins, P-ACCβ / ACCβ ratio showed fluctuations, and both changes in the opposite trend, its turning points are 1.5 h; the long-term exercise can produce FNDC5 proteins, P-ACCβ / ACCβ ratios adaptable, more stable expression of the irisin curve after long-term exercise compared to a one-time exercise.
The Existential Meaning of Couples' Long-Term Experience of Living with Stroke

This study employs Heideggerian hermeneutic phenomenology to uncover the existential meaning of couples' long-term experiences of living with stroke. Transcripts of 23 interviews with stroke survivors and 17 interviews with spouses focusing on the couple perspective were analyzed. The five emerging themes and the constitutive pattern illuminate the existential meaning of stroke and include fear, hope, unfamiliarity, temporality, and reinterpretation of the life-world. The constitutive pattern indicates that life after stroke is characterized by the struggle to adapt to an abruptly twisted and unfamiliar being-in-the-world. Changes in couples' interpretations of their life-world seem to be connected with different interpretations of time and an increased view of life as limited. Health professionals with an empathic understanding of the existential meaning of stroke may better facilitate the reinterpretation of couples' actual life-world. Stroke couples' life-restricting fears of living, dying, and caregiving should be explored further.
A Statistical Analysis of Automated MT Evaluation Metrics for Assessments in Task-Based MT Evaluation

This paper applies nonparametric statistical techniques to Machine Translation (MT) Evaluation using data from a large scale task-based study. In particular, the relationship between human task performance on an information extraction task with translated documents and well-known automated translation evaluation metric scores for those documents is studied. Findings from a correlation analysis of this connection are presented and contrasted with current strategies for evaluating translations. An extended analysis that involves a novel idea for assessing partial rank correlation within the presence of grouping factors is also discussed. This work exposes the limitations of descriptive statistics generally used in this area, mainly correlation analysis, when using automated metrics for assessments in task handling purposes.
Timber Supply Model 96: A Global Timber Supply Model with a Pulpwood Component

This study involves an update of our earlier Timber Supply Model, which was fully developed in our book, The Adequacy Of Global Timber Supply by Sedjo and Lyon (1990), published by Resources for the Future. The new version, called Timber Supply Model 1996 (TSM96), uses an economic market supply/demand approach to project an intertemporal time path of the world's price and output level of industrial wood. As did the original TSM, the TSM96 provides projections of the time path of the equilibrium output levels of the several regions into which the world has been subdivided. A major new feature of TSM96 is that industrial wood, treated as homogeneous in the earlier study, has be subdivided into two different wood types — pulpwood and solidwood. The supply of these two commodities is not independent. Rather they can be viewed as joint products in production. The study develops a base-case projection, which gives the authors' best judgment of the timber situation likely to develop over the next few decades. Over that period total industrial wood production increases from about 1.7 billion cubic meters to 2.3 billion cubic meters, an increase of about 35 percent, while global pulpwood production increases from about 700 million cubic meters in 1995 to about 1.325 billion in 2045. Pulpwood price shows a fairly substantial increase throughout the first one-third of the period, a more modest increase over the second third, and a slight decline during the last third. Solidwood prices are almost the inverse of pulpwood, declining over the first third of the decade, increasing slightly over the next third and increasing in the last third of the decade. Over the whole of the 50-year period overall price increases are 30 percent for pulpwood and only about 8 percent for solidwood.