Miracle-dz/UniFAR-FTUs huggingface dataset:
Modeling the combined effect of RNA-binding proteins and microRNAs in post-transcriptional regulation

Recent studies show that RNA-binding proteins (RBPs) and microRNAs (miRNAs) function in coordination with each other to control post-transcriptional regulation (PTR). Despite this, the majority of research to date has focused on the regulatory effect of individual RBPs or miRNAs. Here, we mapped both RBP and miRNA binding sites on human 3′UTRs and utilized this collection to better understand PTR. We show that the transcripts that lack competition for HuR binding are destabilized more after HuR depletion. We also confirm this finding for PUM1(2) by measuring genome-wide expression changes following the knockdown of PUM1(2) in HEK293 cells. Next, to find potential cooperative interactions, we identified the pairs of factors whose sites co-localize more often than expected by random chance. Upon examining these results for PUM1(2), we found that transcripts where the sites of PUM1(2) and its interacting miRNA form a stem-loop are more stabilized upon PUM1(2) depletion. Finally, using dinucleotide frequency and counts of regulatory sites as features in a regression model, we achieved an AU-ROC of 0.86 in predicting mRNA half-life in BEAS-2B cells. Altogether, our results suggest that future studies of PTR must consider the combined effects of RBPs and miRNAs, as well as their interactions.
The Effect of Leader Positive Affectivity on Team Member Turnover Intention and Team Organizational Citizenship Behavior

This paper develops two models to investigate the effect of team leader positive affectivity (PA) on team member turnover intention and team organizational citizenship behavior (OCB), at the individual and team levels, respectively. A two-wave longitudinal study was conducted involving a survey of 58 team leaders and 174 team members in a large Chinese telecom company across a three-month period. We found that team members’ organization-based self-esteem (OBSE) at Time 1 mediates the relationship between team leader PA at Time 1 and team member turnover intention at Time 2, whereas team aggregated OBSE at Time 1 mediates the relationship between leader PA at Time 1 and team OCB at Time 2.
Partial discharges characterization in spherical voids using ultra-short x-ray pulses

This work aims to an improved characterization of partial discharges (PDs) in spherical voids. Start electrons are created by an ultra-short (50 ns) X-ray pulse to eliminate the statistical time lag and the individual PDs are detected with an ultra-wideband detection circuit and a photomultiplier tube. The minimum PD inception field strength is determined by triggering at different phase angles of the applied ac voltage. From this, also the gas pressure inside the void can be calculated. The observed PD characteristic (pulse height, charge magnitude, rise-time, and pulse width) are in agreement with the theory of streamer-like discharges. The measurement setup allows the exact determination of the phase angle of each PD related to the ac phase and an improved modeling of the PD activity can be made. Further unknown parameters (residual field strength, charge decay time constant) can be determined from comparison of the measurements to PD modeling.
Religion and Coping in Mental Health Care

Acknowledgements Introduction Ch. 1: Mental Health and Religion: A Complex Relationship Ch. 2: Religion in Mental Health Care: Patients' Views Ch. 3: Religion in Mental Health Care: Psychotherapists' Views Ch. 4: Psychotherapy and Religious Problems: Illustration by Means of a Case History Ch. 5: Religious Coping in Two Samples of Psychiatric Inpatients Ch. 6: "When I Find Myself in Times of Trouble . ": Pargament's Religious Coping Scales in the Netherlands Ch. 7: "Bridge over Troubled Water": Further Results Regarding The Receptive Coping Scale Ch. 8: Clinical Psychology of Religion. A Training Model Bibliography Subject Index About the authors
Psychological Effects of the Transition to Retirement

Psychological effects of disengagement from a work life and the transition to retirement are discussed. These effects include partial identity disruption, decision paralysis, diminished self trust, experience of a post retirement void, the search for meaningful engagement in society, development of a retirement/life structure, the confluence of aging and retirement, death anxiety, the critical nurturing of social relationships, and self-actualization. Some aspects of preretirement life that can be predictive of a successful transition are also presented. This article is relevant for both counsellors and retirement advisors, whose clients may be planning retirement or have retired.
Applied Quaternion Optimization Method in Transfer Alignment for Airborne AHRS Under Large Misalignment Angle

The airborne attitude and heading reference system (AHRS) is an inertial system that provides the aircraft with navigation parameters in real time. A new coarse transfer alignment method is proposed for low-accuracy AHRS with a large misalignment angle between AHRS and master inertial navigation system (MINS). The new coarse alignment method is derived from the quaternion-optimization-based in-flight alignment (IFA) method. By resolving the alignment problem in body frame, the proposed method makes full use of the navigation information of MINS and transforms the alignment problem into a quaternion optimization problem. Its accuracy is improved by presenting a two-step iterative algorithm. Compared with the quaternion-optimization-based IFA method, the proposed method is more robust and accurate by introducing the attitude information of MINS. The simulation and experiment results show that the proposed method is applicable to both large and small misalignment angles, and it serves as a nice coarse alignment that permits the implementation of linear error model in fine alignment process.
Pearls and Pitfalls in Evaluating a Student Assistance Program: A Five-Year Case Study

This article presents data from a five-year evaluation-research case study of a large urban schools district's internal Student Assistance Program (SAP). The district employed specially trained and licensed school-based counselors to implement an internal SAP expanded to include tertiary prevention, and modeled after an employee assistance program established for adults. From the population of more than 10,000 students who received some type of program assistance for at-risk behaviors, a stratified random sample of 2,238 cases, over a five year period, were reviewed. Results indicate a statistically significant decline (p < .05) in students' drug use and a significant improvement in internal locus of control occurred each year. While not statistically significant, the average number of student discipline referrals was less than the year prior to program admission; however, there was no significant change in academic performance. A significant correlation between students' drug use and the amount of time in program, the type of assistance received, and the student's custody status was also found.
Putting Out a HIT: Crowdsourcing Malware Installs

Today, several actors within the Internet's burgeoning underground economy specialize in providing services to like-minded criminals. At the same time, gray and white markets exist for services on the Internet providing reasonably similar products. In this paper we explore a hypothetical arbitrage between these two markets by purchasing "Human Intelligence" on Amazon's Mechanical Turk service, determining the vulnerability of and cost to compromise the computers being used by the humans to provide this service, and estimating the underground value of the computers which are vulnerable to exploitation. We show that it is economically feasible for an attacker to purchase access to high value hosts via Mechanical Turk, compromise the subset with unpatched, vulnerable browser plugins, and sell access to these hosts via Pay-Per-Install programs for a tidy profit. We also present supplementary statistics gathered regarding Mechanical Turk workers' browser security, antivirus usage, and willingness to run arbitrary programs in exchange for a small monetary reward.
General Symbol Machines: The First Stage in the Evolution of Symbolic Communication

Humans uniquely form stimulus equivalence (SE) classes of abstract and unrelated stimuli, i.e. if taught to match A with B and B with C, they will spontaneously match B with A, and C with B, (the relation of symmetry), and A with C (transitivity). Other species do not do this. The SE ability is possibly the consequence of a specific selection event in the Homo lineage. SE is of interest because it appears to demonstrate a facility that is core to symbolic behavior. Linguistic symbols, for example, are arbitrarily and symmetrically related to their referent such that the term banana has no resemblance to bananas but when processed can be used to discriminate bananas. Equally when bananas are perceived the term banana is readily produced. This relation is arguably the defining mark of symbolic representation. In this paper I shall detail the SE phenomenon and argue that it is evidence for a cognitive device that I term a General Symbol Machine (GSM). The GSM not only sets the background condition for subsequent linguistic evolution but also for other symbolic behaviors such as mathematical reasoning. In so doing the GSM is not particularly domain-specific. The apparent domain-specificity of, for example, natural language is a consequence of other computational developments. This introduces complexity to evolutionary arguments about cognitive architecture.
What Can We Learn about Retaining Teachers from PDS Teachers’ Voices?

As we seek to increase the quality of individuals entering and remaining in the teaching profession, we are simultaneously faced with a teacher short age, often leading to fast track certification and lat eral entry programs circumventing teacher prepa ration. A high quality teacher is more than just well prepared in content. "Highly qualified" teach ers demonstrate proficiency in pedagogical knowl edge, skills, dispositions, classroom management, and overall effective teaching practices. Finding such individuals without thorough formal prepara Focusing on students motivates well-prepared middle grades teachers. PHOTO BY TIMOTHY L. VACULA
Racial Differences in Vasopressor Requirements for Septic Shock

ABSTRACT Objective: The objective of this study was to compare vasopressor requirements between African American (AA) patients and white patients in septic shock. Methods: This was a retrospective cohort review conducted over a 2-year period measuring total and mean dosage of various vasopressors used between two racial groups during the treatment of patients admitted with septic shock. The study included patients admitted to the intensive care unit with septic shock at an 805-bed tertiary, academic center. All septic shock patients were managed with vasopressors. Vasopressor selection, dosage, and duration were at the discretion of the treating physician. Total, mean, and duration of vasopressor dosing requirements were obtained for study participants. Comorbidities, prehospitalization antihypertensive medication requirements, intravenous fluids given during the septic shock phase, and source of infection were analyzed. Results: One hundred fifty-nine patients with septic shock were analyzed, of which 96 (60.4%) were AAs (P < 0.059). African Americans had higher rates of end-stage renal disease and hypertension compared with whites, 85.7% vs. 14.3% (P < 0.011; odds ratio [OR], 15.684) and 68.3% vs. 31.7% (P < 0.007; OR, 3.357), respectively. Norepinephrine (NE) was administered to 150 patients, 57.2% of which were AAs (P < 0.509). Thirteen patients received dopamine (5% AAs, P < 0.588), 40 patients received phenylephrine (15.7% AAs, P < 0.451), and five patients received epinephrine (1.9% AAs, P < 0.660). Comparing vasopressors between races, only NE showed statistical significance via logistic regression modeling for the AA race in terms of total dosage (AAs 736.8 [SD, 897.3] &mgr;g vs. whites 370 [SD, 554.2] &mgr;g, P < 0.003), duration of vasopressor used (AAs 38.38 [SD, 34.75] h vs. whites 29.09 [SD, 27.11] h, P < 0.037), and mean dosage (AAs 21.08 [SD, 22.23] &mgr;g/h vs. whites 12.37 [SD, 13.86] &mgr;g/h, P < 0.01). Mortality between groups was not significant. Logistic regression identified discrepancy of the mean dose NE in AAs compared with whites, with OR of 1.043 (P = 0.01). Conclusions: African American patients with septic shock were treated with higher doses of NE and required longer duration of NE administration compared with white patients.
Dynamic permeability in a dissipative ferromagnetic medium

It is shown that the dynamic relative permeability in a thin ferromagnetic film with in-plane magnetization in the presence of intrinsic dissipation exhibits negative values for the range of microwave frequencies belonging to those of backward volume spin-wave modes. This is accomplished according to the linearization of the equation of motion in the magnetostatic limit. By studying the coupling of backward volume spin waves with electromagnetic waves in the range of negative permeability the ferromagnetic film can be considered as a magnetic metamaterial.
The Influence of Race and Ethnicity on Complications and Mortality After Orthopedic Surgery: A Systematic Review of the Literature

Background:The decision to perform orthopedic surgery requires substantial discretion and judgment. Similar conditions have been associated with health care disparities in other fields, but the extent of racial and ethnic disparities in orthopedics is unknown. Objective:To evaluate the quality of extant orthopedic literature on health care disparities. Research Design:This study is a systematic review. Subjects:Eligible studies reported complications and/or mortality stratified by minority group after orthopedic surgery in an American population. Measures:Queries of PubMed, Embase, Scopus, and Web of Science were performed. Included papers were abstracted regarding complication and/or mortality rates for whites and minority populations, statistical findings, and whether a health care disparity was reported. Statistical associations between study characteristics and the identification of disparities were evaluated using the &khgr;2 test. Results:The literature search returned 2604 studies, of which 33 met inclusion criteria. All but 3 works dealt with spine surgery or joint replacement. Twenty-one publications (64%) documented health care disparities. Forty-four percent of efforts investigating outcomes for Hispanics and 36% of works documenting results for non-whites recorded a disparity. Investigations reporting on African Americans were significantly more likely to identify health care inequalities (77%) as compared with non-white (P=0.02) cohorts. Conclusions:Patients from racial and ethnic minority populations seem to be at increased risk of complications and/or mortality following spine surgical or joint replacement procedures. There is insufficient evidence to support generalization to the entire orthopedic field. Studies specific to African American patients identify health care disparities at a significantly higher rate than those utilizing non-white cohorts.
Las perspectivas de meta de los adolescentes en el contexto deportivo

Goals perspectives of adolescents in sport context. We examined the construct and predictive validity of the Task and Ego Orientation in Sport Questionnaire (Duda, 1989), the Beliefs About Success in Sport Questionnaire (Duda & Nicholls, 1992), and the Sport Satisfaction Instrument (Duda & Nicholls, 1992) using structural equation modeling and correlational analyses. The sample was comprised of 967 Valencian adolescents between 11 and 16 years. Confirmatory factor analyses provided evidence regarding the factorial structure of the instruments. Support for the predictive utility of the questionnaires was also garnered. Results revealed two goal-beliefs factors or personal theories of achievement that were consistent with previous research. Adolescents who were high on the Task Goal-Belief factor reported greater enjoyment of sport and less boredom experienced. Scores on the Ego Goal-Belief factor were positively related to boredom in sport. The implications of these findings in terms of maximising students' investment in the physical domain are discussed.
High-Level Vision: Object Recognition and Visual Cognition

Object recognition: shape-based recognition what is recognition? why object recognition is difficult. Approaches to object recognition: invariant properties and feature spaces parts and structural descriptions the alignment approach which is the correct approach? The alignment of pictorial descriptions: using corresponding features the use of multiple models for 3-D objects aligning pictorial descriptions transforming the image or the models? before and after alignment. The alignment of smooth bounding contours: the curvate method accuracy of the curvature method empirical testing. Recognition by the combination of views: modelling objects by view combinations objects with sharp edges using two views only using a single view the use of depth values summary of the basic scheme objects with smooth boundaries recognition by image combinations extensions to the view-combination scheme psychophysical and physiological evidence interim conclusions: recognition by multiple views. Classifications: classification and identification the role of object classification class-based processing using class prototypes pictorial classification evidence from psychology and biology are classes in the world or in our head? the organization of recognition memory. Image and model correspondence: feature correspondence contour matching correspondence-less methods correspondence processes in human vision model construction compensating for illumination changes. Segmentation and saliency: is segmentation feasible? bottom-up and top-down segmentation extracting globally salient structures saliency, selection, and completion what can bottom-up segmentation achieve? Visual cognition and visual routines: perceiving "inside" and "outside" spatial analysis by visual routines conclusions and open problems the elemental operations the assembly and storage of routines routines and recognition. Sequence seeking and counter streams - a model for visual cortex: the sequence-seeking scheme biological embodiment summary. Appendices: alignment by feature the curvature method errors of the curvature method locally affine matching definitions.
Health inequality : an introduction to theories, concepts and methods

What is health inequality -- Measuring socio-economic position -- Figuring out health inequality -- Models of aetiological pathways I: behavioural and 'cultural' explanations -- Models of aetiological pathways II: the psychosocial model -- Models of aetiological pathways III: the materialist model -- Models of aetiological pathways IV: the life course approach -- Social ecology -- Gender inequality in health -- Ethnic inequalities in health -- Health inequality and social policy.
The supremum of a negative drift random walk with dependent heavy-tailed steps

Many important probabilistic models in queuing theory, insurance and finance deal with partial sums of a negative mean stationary process (a negative drift random walk), and the law of the supremum of such a process is used to calculate, depending on the context, the ruin probability, the steady state distribution of the number of customers in the system or the value at risk. When the stationary process is heavy-tailed, the corresponding ruin probabilities are high and the stationary distributions are heavy-tailed as well. If the steps of the random walk are independent, then the exact asymptotic behavior of such probability tails was described by Embrechts and Veraverbeke. We show that this asymptotic behavior may be different if the steps of the random walk are not independent, and the dependence affects the joint probability tails of the stationary process. Such type of dependence can be modeled, for example, by a linear process.
Differences Between Novice and Expert Systems Analysts: What Do We Know and What Do We Do?

Due to increased organizational dependence on information systems technology, the effectiveness of the systems analyst is more crucial today than ever. Despite technological advances that have increased the number and quality of tools available to systems analysts, the individual analyst's problem-solving skills remain key to defining good systems requirements. Understanding how expert analysts approach the requirements analysis task may provide insights for improving the effectiveness of novice analysts. This paper examines differences in the problem-solving approaches of novice and expert systems analysts during an information requirements task. Specific weaknesses that set novice and expert analysts apart are identified, and techniques that may be used to strengthen novice skills are suggested. This research supports the current literature on creativity techniques as a strategy for strengthening system analysis skills.
A Novel Multi-objective Affinity Set Classification System: An Investigation of Delayed Diagnosis Detection

This paper proposed a novel multi-objective affinity set (MO affinity set) classification system comparing with Ant colony optimization (ACO) and affinity set theory on delayed diagnosis dataset classification. The output of MO affinity set classification rules has the higher accuracy than ACO and traditional affinity set. Furthermore, our MO affinity set classification skips the traditional affinity set k-core method, and has fewer rules. It is better and more easily to apply or to construct a support system if the number of rules is smaller.
Effects of Diet Composition and Insulin Resistance Status on Plasma Lipid Levels in a Weight Loss Intervention in Women

Background Optimal macronutrient distribution of weight loss diets has not been established. The distribution of energy from carbohydrate and fat has been observed to promote differential plasma lipid responses in previous weight loss studies, and insulin resistance status may interact with diet composition and affect weight loss and lipid responses. Methods and Results Overweight and obese women (n=245) were enrolled in a 1‐year behavioral weight loss intervention and randomly assigned to 1 of 3 study groups: a lower fat (20% energy), higher carbohydrate (65% energy) diet; a lower carbohydrate (45% energy), higher fat (35% energy) diet; or a walnut‐rich, higher fat (35% energy), lower carbohydrate (45% energy) diet. Blood samples and data available from 213 women at baseline and at 6 months were the focus of this analysis. Triglycerides, total cholesterol, and high‐ and low‐density lipoprotein cholesterol were quantified and compared between and within groups. Triglycerides decreased in all study arms at 6 months (P<0.05). The walnut‐rich diet increased high‐density lipoprotein cholesterol more than either the lower fat or lower carbohydrate diet (P<0.05). The walnut‐rich diet also reduced low‐density lipoprotein cholesterol in insulin‐sensitive women, whereas the lower fat diet reduced both total cholesterol and high‐density lipoprotein cholesterol in insulin‐sensitive women (P<0.05). Insulin sensitivity and C‐reactive protein levels also improved. Conclusions Weight loss was similar across the diet groups, although insulin‐sensitive women lost more weight with a lower fat, higher carbohydrate diet versus a higher fat, lower carbohydrate diet. The walnut‐rich, higher fat diet resulted in the most favorable changes in lipid levels. Clinical Trial Registration URL: http://www.clinicaltrials. gov. Unique identifier: NCT01424007.
A fast method to estimate body capacitance to ground

This paper describes a method to estimate the capacitance between the human body and earth ground that is based on an impedance analyzer intended to measure ungrounded impedances. The method does not need any external components other than two common resistors, works in the 10 kHz to 1 MHz frequency range, and can be applied to other grounded impedances.