Miracle-dz/UniFAR-FTUs huggingface dataset:
Ventilator-associated pneumonia rates at major trauma centers compared with a national benchmark: A multi-institutional study of the AAST

BACKGROUND: Ventilator-associated pneumonia (VAP) rates reported by the National Healthcare Safety Network (NHSN) are used as a benchmark and quality measure, yet different rates are reported from many trauma centers. This multi-institutional study was undertaken to elucidate VAP rates at major trauma centers. METHODS: VAP rate/1,000 ventilator days, diagnostic methods, institutional, and aggregate patient data were collected retrospectively from a convenience sample of trauma centers for 2008 and 2009 and analyzed with descriptive statistics. RESULTS: At 47 participating Level I and II centers, the pooled mean VAP rate was 17.2 versus 8.1 for NHSN (2006–2008). Hospitals' rates were highly variable (range, 1.8–57.6), with 72.3% being above NHSN′s mean. Rates differed based on who determined the rate (trauma service, 27.5; infection control or quality or epidemiology, 11.9; or collaborative effort, 19.9) and the frequency with which VAP was excluded based on aspiration or diagnosis before hospital day 5. In 2008 and 2009, blunt trauma patients had higher VAP rates (17.3 and 17.6, respectively) than penetrating patients (11.0 and 10.9, respectively). More centers used a clinical diagnostic strategy (57%) than a bacteriologic strategy (43%). Patients with VAP had a mean Injury Severity Score of 28.7, mean Intensive Care Unit length of stay of 20.8 days, and a 12.2% mortality rate. 50.5% of VAP patients had a traumatic brain injury. CONCLUSIONS: VAP rates at major trauma centers are markedly higher than those reported by NHSN and vary significantly among centers. Available data are insufficient to set benchmarks, because it is questionable whether any one data set is truly representative of most trauma centers. Application of a single benchmark to all centers may be inappropriate, and reliable diagnostic and reporting standards are needed. Prospective analysis of a larger data set is warranted, with attention to injury severity, risk factors specific to trauma patients, diagnostic method used, VAP definitions and exclusions, and reporting guidelines. LEVEL OF EVIDENCE: III, prognostic study.
International Capital Flows and the Return to Safe Assets in the United States, 2003-2007

A broad array of domestic institutional factors –including problems with the originate-to-distribute model for mortgage loans, deteriorating lending standards, deficiencies in risk management, conflicting incentives for the government-sponsored enterprises (GSEs), and shortcomings of supervision and regulation– were the primary sources of the US housing boom and bust and the associated financial crisis. In addition, the extended rise in US house prices was likely also supported by long-term interest rates (including mortgage rates) that were surprisingly low, given the level of short-term rates and other macro fundamentals –a development that Greenspan (2005) dubbed a “conundrum. ” The “global saving glut” (GSG) hypothesis (Bernanke, 2005 and 2007) argues that increased capital inflows to the United States from countries in which desired saving greatly exceeded desired investment –including Asian emerging markets and commodity exporters– were an important reason that US longer-term interest rates during this period were lower than expected. This essay investigates further the effects of capital inflows to the United States on US longer-term interest rates; however, we look beyond the overall size of the inflows emphasised by the GSG hypothesis to examine the implications for US yields of the portfolio preferences of foreign creditors. We present evidence that, in the spirit of Caballero and Krishnamurthy (2009), foreign investors during this period tended to prefer US assets perceived to be safe. In particular, foreign investors –especially the GSG countries–acquired a substantial share of the new issues of US Treasuries, Agency debt, and Agency-sponsored mortgage-backed securities. The downward pressure on yields exerted by inflows from the GSG countries was reinforced by the portfolio preferences of other foreign investors. We focus particularly on the case of Europe: although Europe did not run a large current account surplus as did the GSG countries, we show that it leveraged up its international balance sheet, issuing external liabilities to finance substantial purchases of apparently safe US “private label” mortgage-backed securities and other fixed-income products. The strong demand for apparently safe assets by both domestic and foreign investors not only served to reduce yields on these assets but also provided additional incentives for the US financial services industry to develop structured investment products that “transformed” risky loans into highly-rated securities. Our findings do not challenge the view that domestic factors, including those listed above, were the primary sources of the housing boom and bust in the United States. However, examining how changes in the pattern of international capital flows affected yields on US assets helps provide a deeper understanding of the origins and dynamics of the crisis.
Targeting Gene‐ViroTherapy for prostate cancer by DD3‐driven oncolytic virus‐harboring interleukin‐24 gene

Prostate cancer (PCa) is the second leading cause of cancer‐related deaths in Western male population. Previous studies have demonstrated that differential display code 3 (DD3 or DD3PCA3) is one of the most PCa‐specific genes; therefore, it has been used as a clinical diagnostic marker for PCa. In this study, we constructed an oncolytic adenovirus Ad.DD3‐E1A by using the minimal DD3 promoter to replace the native viral promoter of E1A gene. In addition, Ad.DD3‐E1A was armed with therapeutic gene IL‐24 to enhance its antitumor activity. The resulting adenovirus, Ad.DD3‐E1A‐IL‐24, demonstrated PCa specificity and excellent antitumor effect. Further analyses on its antitumor mechanism revealed that it has the capacity to induce apoptosis in PCa cells and inhibit angiogenesis. These results suggest that Ad.DD3‐E1A‐IL‐24 is a promising antitumor agent that may be able to be used in the future as a treatment for PCa.
Metabolic Syndrome: Criteria for Diagnosing in Children and Adolescents

Metabolic Syndrome (MS) is defined as a group of risk factors related to insulin resistance and its highest prevalence is found in obese individuals. The first observations concerning MS occurred in the 1920s, contributing to a surge of new associations between hyperglycemia and obesity. As of 1979, there was a greater understanding of one of its components: insulin resistance. The prevalence of MS varies according to the diagnostic criterion used, mainly for children and adolescents among which its prevalence has increased considerably. The principle criteria used in diagnosing the pediatric population are the International Diabetes Federation (IDF), National Cholesterol Education Program and Adult Treatment Panel III (NCEP-ATP III), World Health Organization (WHO) and I Prevention Directive against Atherosclerosis in Infancy and Adolescence, and due to their differences, the prevalence of the syndrome varies according to the diagnostic criterion used. Nevertheless, many points should be taken into consideration in choosing a criterion, such as sample size, age, applicability, risk factors to be considered and available resources. In this context, efficiency and applicability are advantages in distinct criteria.
Why Do Poor democracies Collect a Lot of Tariff Revenue

Governments in developing countries typically collect a significantly higher proportion of their revenue in the form of trade taxes, than their developed country counterparts. This paper provides a political-economic explanation for this phenomenon. A model of trade in vertically differentiated products is used in order to determine the preferences of the households among different ways of raising government revenue. It is shown that the majority of households in poor countries will consume low-quality, domestically produced varieties of differentiated products and would thus register a preference for the government to rely more on tariff rather than income tax revenue in order to finance its operations. Copyright Blackwell Publishers Ltd.
How to Engage with the Private Sector in Public-Private Partnerships in Emerging Markets

What transforms a desirable project on a government wish list to an attractive investment opportunity in the eyes of a potential private sector partner? This guide seeks to enhance the chances of developing effective partnerships between the public and the private sectors by addressing one of the main obstacles to the effective delivery of public-private partnership (PPP) projects: having the right information on the right project for the right partners at the right time. Data from the World Bank and the Public-Private Infrastructure Advisory Facility (PPIAF) private participation in infrastructure (PPI) project database indicate that private sector investment in infrastructure in developing economies grew steadily over the past decade. By 2007 the levels had finally surpassed the peak levels seen in 1997, the end of the previous growth spurt. This guide focuses specifically on what should be done, and when, in order to prepare projects to attract the right long-term private partners, procure their involvement, and manage the partnership. This guide is not a detailed project preparation manual; rather, it seeks to provide an overview of the process and what is involved so that greater realism can be applied to this challenging task and adequate resource plans can be developed.
Kids on board: methodological challenges, concerns and clarifications when including young children's voices in tourism research

A knowledge gap exists concerning the dearth of children's voices in tourism research. One of the main reasons for this is attributed to the methodological challenges that confront researchers when interacting with child respondents. Based on a recent study conducted with young children between the ages of 5 and 6 years, this article discusses five methodological issues to contemplate prior to conducting research with children. This article raises important considerations for children's developmental phase, the use of appropriate props and prompts during data collection, and the positionality and pre-requisites of the researcher when designing methodologies for research with children.
Market orientation and innovation: an inter‐relationship analysis

Purpose – Market orientation analyses have focused on two broad‐ranging approaches: the behavioural and the philosophical. The concepts of innovation and market orientation are gaining ground steadily in the context of an increasingly competitive and highly volatile environment, subject to the pressures of rapid‐changing customer needs and desires. This premise underlies the general aim of this study, which is to determine to what extent companies operating in the same sector and with similar market orientation are similarly concerned about innovation.Design/methodology/approach – The population for this study comprises the leading 465 textile companies operating in Spain, listed in the ARDAN database. Data were gathered from in‐depth personalised interviews with 17 company directors operating within the textile sector. In order to verify the hypotheses, groups with similar market orientation were identified using a combination of two techniques: multidimensional scaling analysis; and cluster analysis. Af.
Sequences of the second internal transcribed spacer of ribosomal DNA for three species of Trichostrongylus (Nematoda: Trichostrongylidae) from sheep in Russia

SummaryFor the first time, DNA sequence data were obtained for three species of Trichostrongylus from Russia. Internal transcribed spacer (ITS-2) of ribosomal DNA was sequenced for T. axei, T. colubriformis and T. probolurus from sheep from the Moscow region. ITS-2 rDNA length was estimated as 238 nucleotides for T. colubriformis and T. probolurus and 237 nucleotides for T. axei. The G+C content of the ITS-2 sequences of T. colubriformis, T. axei and T. probolurus were 31 %, 32 % and 34 % respectively. The level of interspecific differences in ITS-2 of rDNA of T. axei, T. probolurus and T. colubriformis ranged from 3 to 4 %. The ITS-2 sequences from the Russian specimens were compared with those of T. axei, T. probolurus and T. colubriformis from Australia and Germany. Intraspecific variation ranged from 0 % in T. colubriformis to 3.0 % in T. axei.
Design and Experimental Validation of a Mode-Stirred Reverberation Chamber at Millimeter Waves

The purpose of this paper is to analyze the behavior of a mode-stirred reverberation chamber at millimeter waves. An experimental chamber with 0.423m × 0.412m × 0.383m dimensions has been built taking into account mechanical, electromagnetic, and measurement constraints for operation in Ka, U, and V bands. Its design warrants a relatively high quality factor (9 ×104 at 60 GHz), which is confirmed by measurements using frequency stirring. The statistical behavior of the experimental electromagnetic field inside the chamber in the 58.5-61.5-GHz range is consistent with that of a classical reverberation chamber. To the best of our knowledge, this is one of the first reverberation chamber designed and optimized around 60 GHz. It can be used as a test facility for electromagnetic interference and compatibility measurements at millimeter waves as well as for bioelectromagnetic applications.
A Comparative Study on Chemical Composition and Pharmacological Effects of Paecilomyces hepiali and Wild Ophiocordyceps sinensis

This study looked at comparison of chemical components and pharmacological activity between wild Ophiocordyceps sinensis and Paecilomyces hepiali. The chemical components investigated included amino acids, vitamins, dietary elements, protein, lipid, ash, carbohydrates, crude fibre, ergosterol and mannitol. Studies on pharmacological activity included anti-platelet aggregation, inhibitory effect on IL-8 gene expression, anti-mutagenic activity, skin whitening effect and impro- vement activity on human skin texture. The results show that P. hepiali has a larger total content of seven essential amino acids (leucine, lysine, methionine, phenylalanine, tryptophan, tyrosine and valine) than O. sinensis, 8580 mg/100g and 6180 mg/100g respectively. The total content of dietary elements analysed (potassium, magnesium, zinc, copper, manganese and selenium) was also higher in P. hepiali (3135 mg/100g) than that in O. sinensis (2445 mg/100g). The total content of four vitamins (B1, B2, B6 and E) was almost equal for both fungi. Paecilomyces hepiali had more content of protein, lipid, ash, carbohydrate, ergosterol and mannitol than O. sinensis. However, the contents of lipid and ash were not significantly different between the two fungi. The hot water extract of P. hepiali has been shown to have a number of pharmacological effects which include 1) inhibition of aggregation on human platelet, 2) inhibition of IL-8 gene expression, 3) anti-mutage- nic activity, 4) inhibition effect on production of melanin, and 5) improvement on human skin texture. Anti-platelet aggregation effects on human platelet, inhibition of IL-8 gene expression, anti-mutagenic activity and improvement effect on human skin texture were greater in P. hepiali treatments than that in wild O. sinensis.
Economic development under the Coalition Government

The general election in the UK in March 2010 resulted in the formation of a ‘Coalition’ Government between the Conservative Party and the Liberal Democrats. Replacing 13 continuous years of Labour governments signified that the Coalition would seek to implement some form of institutional restructuring that would influence the shape and practice of economic development, although the resultant organisational manoeuvrings have been starker than many originally anticipated. It is this context of politically induced policy reform that provides fertile ground for investigation and critical analysis. Beyond the act of forging policies of compromise, an immediate challenge facing the embryonic government was to respond to the spatially variable repercussions of a national economic recession following the Credit Crunch of 2007–2008, marked in part by the collapse among others of the Lehman Brothers Bank in the US and state-led rescue packages for UK financial institutions such as Northern Rock, which wielded worldwide ripple effects. Growth slowed in the UK, unemployment was rising, and interest rates, house prices and consumption were all declining. Business loans and bank lending were punitively restrictive and investor confidence was plummeting. The recession impacted the UK regions in differential ways with the English north–south divide exacerbated. This prompted arguments, which gained traction with the Coalition Government, that extant regional policies had failed to tackle the problem of disparities (Overman and Gibbons, 2011). Ministers began to evoke a zealous antiregionalist discourse (Shaw and Robinson, 2012) whereby administering policy according to the concept of regional economies was quickly rendered ‘a non-starter’, with the Communities Secretary, Eric Pickles, amongst other ministers, claiming that regional institutional architecture generates arbitrary scales of territorial organisation, reflecting ‘bureaucratic convenience’ rather than the interests of business and other local actors. Of fatal concern, as far as the incoming government was concerned, was the level of state borrowing which was forecast to be 118bn in 2009 (House of Commons,
PD-L1 expression is associated with p16INK4A expression in non-oropharyngeal head and neck squamous cell carcinoma

PD-L1 expression is critical in helping tumor cells evade the immune system. However, the level of PD-L1 expression in non-oropharyngeal head and neck squamous cell carcinoma (non-OPHNSCC) and its association with patient prognosis remains unclear. A retrospective clinicopathological analysis was performed on 106 patients with non-OPHNSCC diagnosed between 2007 and 2014. In the current study, tissue arrays from paraffin-embedded non-OPHNSCC samples obtained from patients were constructed, and PD-L1 and p16INK4A expression were determined using immunohistochemistry. Systemic inflammatory factors, including C-reactive protein, serum white blood cell, neutrophil, monocyte and lymphocyte counts were also analyzed. The current study demonstrated that PD-L1 was overexpressed in 32.1% (34/106) and p16INK4A in 20.8% (22/106) of patients. The expression of PD-L1 was associated with p16INK4A expression (P<0.01) but was not associated with levels of systemic inflammatory factors. Tumor stage was determined to be a significant prognostic value (stage I/II vs. III/IV, P=0.03), however, PD-L1, p16INK4A or other clinicopathological factors were not. The current study identified an association between PD-L1 and p16INK4A expression in non-OPHNSCC. This may facilitate the development of anti-PD1/PDL1 therapies to treat patients with head and neck cancer.
Promoting CSR to foster sustainable development

Purpose – The purpose of this paper is to explore the attitudes and perceptions of senior managers in Bangladesh with regard to corporate social responsibility (CSR), focusing on the impact of CSR promotional programmes in fostering an affirmative view of sustainable development. This issue has special significance in a country that is one of the fastest growing economies in south Asia and also particularly vulnerable to the effects of climate change. Design/methodology/approach – Data were collected through semi-structured interviews with a diverse group of 32 managers of large enterprises operating in a variety of industries. Findings – The positive attitudes observed suggest that various programmes adopted to promote CSR have had some effect. However, sustainable development and environmental issues tend to remain on the periphery of managers’ understandings and perceptions of CSR. Research limitations/implications – This study aids understanding of how business managers may respond to CSR promotional .
Greed, Death, and Values: From Terror Management to Transcendence Management Theory

Research supporting terror management theory has shown that participants facing their death (via mortality salience) exhibit more greed than do control participants. The present research attempts to distinguish mortality salience from other forms of mortality awareness. Specifically, the authors look to reports of near-death experiences and posttraumatic growth which reveal that many people who nearly die come to view seeking wealth and possessions as empty and meaningless. Guided by these reports, a manipulation called death reflection was generated. In Study 1, highly extrinsic participants who experienced death reflection exhibited intrinsic behavior. In Study 2, the manipulation was validated, and in Study 3, death reflection and mortality salience manipulations were compared. Results showed that mortality salience led highly extrinsic participants to manifest greed, whereas death reflection again generated intrinsic, unselfish behavior. The construct of value orientation is discussed along with the contrast between death reflection manipulation and mortality salience.
Both amino- and carboxyl-terminal sequences within I kappa B alpha regulate its inducible degradation

Nuclear expression and consequent biological action of the eukaryotic NF-kappa B transcription factor complex are tightly regulated through its cytoplasmic retention by an ankyrin-rich inhibitory protein termed I kappa B alpha. I kappa B alpha specifically binds to and masks the nuclear localization signal of the RelA subunit of NF-kappa B, thereby effectively sequestering this transcription factor complex in the cytoplasm. Specific cellular activation signals lead to the rapid proteolytic degradation of I kappa B alpha and the concomitant nuclear translocation of NF-kappa B. However, the precise biochemical mechanisms underlying the inhibitory effects of I kappa B alpha on RelA and its inducible pattern of degradation remain unclear. By using HeLa cells transfected with various cDNAs end-coding epitope-tagged mutants of I kappa B alpha, our studies demonstrate the following: (i) sequences within the 72-amino-acid N-terminal region of I kappa B alpha are required for tumor necrosis factor alpha (TNF-alpha)-induced degradation but are fully dispensable for I kappa B alpha binding to and inhibition of RelA; (ii) serine residues located at positions 32 and 36 within the N-terminal region of I kappa B alpha represent major sites of induced phosphorylation (substitution of these serine residues with alanine abrogates TNF-alpha-induced degradation of I kappa B alpha); (iii) the C-terminal 40 residues of I kappa B alpha (amino acids 277 to 317), which include a PEST-like domain, are entirely dispensable for TNF-alpha-induced degradation and inhibition of RelA; (iv) a glutamine- and leucine-rich (QL) region of I kappa B alpha located between residues 263 and 277 and overlapping with the sixth ankyrin repeat is required for both inducible degradation and inhibition of RelA function; (v) regulation of I kappa B alpha degradation by this QL-rich region appears to occur independently of phosphorylation at serines 32 and 36. These findings thus indicate that I kappa B alpha is generally organized within distinct modular domains displaying different functional and regulatory properties. These studies have also led to the identification of a novel class of dominant-negative I kappa B alpha molecules that retain full inhibitory function on NF-kappa B yet fail to undergo stimulus-induced degradation. These molecules, which lack N-terminal sequences, potently inhibit TNF-alpha-induced activation of the human immune deficiency virus type 1 kappa B enhancer, thus indicating their possible use as general inhibitors of NF-kappa B.