Miracle-dz/UniFAR-FTUs huggingface dataset:
Visceral adiposity index is associated with histological findings and high viral load in patients with chronic hepatitis C due to genotype 1

Metabolic factors have been associated with liver damage in patients with genotype 1 chronic hepatitis C (G1 CHC). We tested visceral adiposity index (VAI), a new marker of adipose dysfunction in G1 CHC, patients to assess its association with host and viral factors and its link to both histological findings and sustained virological response (SVR). Two hundred thirty‐six consecutive G1 CHC patients were evaluated by way of liver biopsy and anthropometric and metabolic measurements, including insulin resistance (IR), homeostasis model assessment (HOMA), and VAI using waist circumference, body mass index, triglycerides, and high‐density lipoprotein cholesterol. All biopsies were scored by one pathologist for staging and grading and graded for steatosis, which was considered moderate to severe if ≥30%. Multiple linear regression analysis revealed that VAI score was independently associated with higher HOMA score (P = 0.009), log10 hepatitis C virus RNA levels (P = 0.01), necroinflammatory activity (P = 0.04), and steatosis (P = 0.04). Multiple logistic regression analysis revealed that IR (OR 3.879, 95% CI 1.727‐8.713, P = 0.001), higher VAI score (OR 1.472, 95% CI 1.051‐2.062, P = 0.02), and fibrosis (OR 2.255, 95% CI 1.349‐3.768, P = 0.002) were linked to steatosis ≥30%. Logistic regression analysis revealed that older age (OR 1.030, 95% CI 1.002‐1.059, P = 0.03), higher VAI score (OR 1.618, 95% CI 1.001‐2.617, P = 0.04), and fibrosis (OR 2.608, 95% CI 1.565‐4.345, P < 0.001) were independently associated with moderate to severe necroinflammatory activity. No independent associations were found between VAI score and both fibrosis and SVR. Conclusion: In G1 CHC patients, higher VAI score is independently associated with both steatosis and necroinflammatory activity and has a direct correlation with viral load. (HEPATOLOGY 2010.)
Safety of new oral anticoagulant drugs: a perspective

The recent development of new oral anticoagulants (NOACs) offers the possibility of efficacy, relative safety and convenience compared with warfarin. This could lead to greater patient compliance, with easier management and improved provision of thromboprophylaxis. Safety whilst using NOACs should be focused on bleeding cases, surgery or on the management of patients receiving anticoagulant therapy with concomitant impairment of renal function, especially since many NOACs are dependent on renal excretion. Thus, if the clearance creatinine indicates severe renal impairment, NOACS will be contraindicated or their dose needs to be changed. In patients who need surgery, there are published protocols of management, depending on the severity of the intervention and renal function. In the case of severe hemorrhage, requiring rapid reversal of the anticoagulant effect and in the absence of specific antidotes, alternatives such as one of the nonspecific haemostatic agents must be considered. Clinical evaluation in bleeding situations and a meticulous risk–benefit appraisal for NOACs is needed, and these procoagulant agents and patients must be monitored closely. This article provides an overview of the pharmacology and potential risks, as well as the efficacy and safety of NOACs.
The impact of hunting with dogs on wildlife harvests in the Bosawas Reserve, Nicaragua

SUMMARY Although they are used throughout the Neotropics, the impact of dogs on the composition of wildlife harvests has received little systematic attention. In the Bosawas Biosphere Reserve of Nicaragua, indigenous hunters rely heavily on dogs to locate prey. Hunting harvest data over a year-long period in two indigenous Mayangna and Miskito communities indicate that the use of hunting dogs is significantly associated with the harvests of several terrestrial mammalian species. The use of dogs is also a significant predictor of the extent to which the species composition of harvests deviates from Neotropical averages. Although dogs appear to have little effect on the sex profiles of harvested game species, the use of dogs is significantly associated with hunting in agricultural landscapes. From a conservation perspective, the disadvantages of dogs include their indiscriminate pursuit of prey species, including species that hunters would not otherwise pursue. Advantages of dogs include their relative ineffectiveness in pursuits of species that are particularly vulnerable to overhunting, such as primates and white-lipped peccaries (Tayassu pecari). Hunting dogs may be an economical option for many Neotropical societies, and their role in wildlife management plans merits increased attention from conservationists.
The Effects of Prosocial and Self-Focused Behaviors on Psychological Flourishing

When it comes to the pursuit of happiness, popular culture encourages a focus on oneself. Whether engaging in self-focused behaviors is the best approach to foster happiness, however, is short on empirical support. By contrast, substantial evidence suggests that focusing on others (i.e., engaging in prosocial behavior) consistently improves happiness. In the current study, I contrasted the mood- and well-being boosting effects of prosocial behaviors (i.e., doing acts of kindness for others or for the world) and self-oriented behaviors (i.e., doing acts of kindness for oneself) in a 6-week longitudinal experiment. Across a diverse sample of participants (N = 473), I found that two types of prosocial behavior led to greater increases in emotional, psychological, and social well-being than did self-focused and neutral behaviors. In addition, I provide evidence for a mechanism explaining the relative improvements in psychological flourishing among participants assigned to engage in prosocial behaviors—namely, increases in positive emotions and decreases in negative emotions. Moreover, those assigned to engage in self-focused behaviors did not improve psychological flourishing, positive emotions, or negative emotions relative to a neutral control group. The results of this study contribute to a growing body of evidence supporting the benefits of prosocial behavior and challenge the popular perception that focusing on oneself is an optimal method to improve one’s mood. People who are striving to improve their happiness may be tempted to treat themselves; however, results of the current study suggest that they may be more successful if they opt to treat someone else instead.
The experience of time in the transition from hospital to home following stroke.

This paper reports findings related to the transition from hospital to home during the first month after discharge following acute stroke. Qualitative data were obtained from in-depth, semistructured interviews with 51 male stroke survivors and their caregivers. Data were analyzed with the N6 software application, designed to assist with qualitative data analysis. Stroke survivors described experiences related to changes in the temporal order of life, disruptions in sense of self, and strategies used to manage time. Findings indicate that changes in the temporal order of life are related to functional impairments and disruption in the taken-for-granted body. At 1 month post-discharge, survivors are struggling with establishing routines in their day and coping with an increased amount of idle time. In conclusion, strategies for managing increased idle time are "passing time," "waiting on time," and "killing time. "
Genetic consequences of sex-biased dispersal in a solitary carnivore: Yellowstone cougars

Male-biased dispersal is a common trait in mammals, including carnivores, but its genetic consequences at the population level have been rarely considered for solitary species. We used long-term genetic data from cougars (Puma concolor) in and around Yellowstone National Park to test predictions based on differences in dispersal behaviour among males and females. Consistent with frequent long-distance dispersal of males, we found support for our prediction of less than expected allele sharing in pair-wise comparisons. In contrast, female residents present at the same time and females separated by few generations failed to share more alleles than expected, contrary to our predictions based on limited female dispersal. However, we find that genetic contributions of females with higher reproductive success were still noticeable in subsequent generations, consistent with female offspring showing fidelity to their natal area. These results highlight the importance of male dispersal for inbreeding avoidance, but do not indicate that short-distance dispersal or philopatry in female cougars results in spatial clustering of related individuals.
GLUT 1 CBP ( TIP 2 / GIPC 1 ) Interactions with GLUT 1 and Myosin VI : Evidence Supporting an Adapter Function for GLUT 1 CBP □

We identified a novel interaction between myosin VI and the GLUT1 transporter binding protein GLUT1CBP(GIPC1) and first proposed that as an adapter molecule it might function to couple vesicle-bound proteins to myosin VI movement. This study refines the model by identifying two myosin VI binding domains in the GIPC1 C terminus, assigning respective oligomerization and myosin VI binding functions to separate Nand C-terminal domains, and defining a central region in the myosin VI tail that binds GIPC1. Data further supporting the model demonstrate that 1) myosin VI and GIPC1 interactions do not require a mediating protein; 2) the myosin VI binding domain in GIPC1 is necessary for intracellular interactions of GIPC1 with myosin VI and recruitment of overexpressed myosin VI to membrane structures, but not for the association of GIPC1 with such structures; 3) GIPC1/myosin VI complexes coordinately move within cellular extensions of the cell in an actin-dependent and microtubule-independent manner; and 4) blocking either GIPC1 interactions with myosin VI or GLUT1 interactions with GIPC1 disrupts normal GLUT1 trafficking in polarized epithelial cells, leading to a reduction in the level of GLUT1 in the plasma membrane and concomitant accumulation in internal membrane structures.
Top-down control of visual attention and awareness : cognitive and neural mechanisms.

Recent behavioural and neural research suggests that awareness is intimately related to top-down cognitive functions such as attention. Here I present a characterization of this relationship, guided by Lavie's load theory. Load theory proposes that perception has limited capacity but proceeds automatically on all stimuli (whether relevant to the task at hand or not) until capacity is exhausted, and that the allocation of processing resources to certain stimuli (rather than to other, competing ones) is guided by executive control functions such as working memory. The theory predicts that increasing the perceptual load of a task will consume capacity, therefore reducing processing of stimuli external to that task it also predicts that increasing working memory load will impair executive control, leading to increased processing of salient ignored stimuli. Here I show that these predictions hold not only for indirect measures of perceptual processing, as has been demonstrated previously, but also for visual awareness - the subjective experience of seeing and being able to report the nature of a visual stimulus. I find that under high perceptual load, observers become less aware of the very presence of other stimuli, even when these stimuli are fully expected and serve as targets. I also show that perceptual load affects the temporal resolution of visual awareness - under high load, the ability to detect a temporal pattern (luminance flicker) is reduced, leading to a subjective percept of steady illumination. In a neuroimaging study, I show that subjective awareness of flicker is associated with activity in frontal and parietal brain regions previously associated with attention and awareness. Next, I investigate the role of executive control in visual awareness by examining the effect of working memory load on binocular rivalry, a fundamental form of visual competition. I find that high working memory load reduces dominance durations in rivalry, suggesting that working memory may serve to maintain perceptual biases during competitive interactions in visual awareness. Finally, I use Transcranial Magnetic Stimulation to establish a causal role for the previously described right parietal involvement in the control of binocular rivalry. This research therefore indicates that top- down cognitive and neural mechanisms are involved in determining whether visual stimuli will reach awareness, and in shaping the subjective nature of the experience such stimuli evoke.
Caring for a Memory-Impaired Spouse:

Since caregiving is often viewed as an extension of the female's traditional role of caring, it could easily be assumed that women would have the advantage in the role of primary caregiver to an impaired partner. Research however does not support this. Rather, studies have found that women, and particularly wives, who are caring for a memory impaired relative have repeatedly identified greater distress in the caregiving role than their male counterparts. Unfortunately, to date, the differential reactions of women are poorly understood. This limits effective intervention. The purpose of this article then, is to begin to develop a framework for conceptualizing the gendered impact of caring for a memory-impaired partner in order to better understand women's, and particularly wives', reaction. Specifically, using a relational perspective the experience of living with a memory impaired husband will be explored.
Chronic inflammation, chronic obstructive pulmonary disease, and lung cancer

Purpose of review Smoking is a major risk factor for lung cancer, which is the leading cause of cancer-related deaths both in the USA and worldwide. Chronic obstructive pulmonary disease and emphysema are comorbid conditions often found in lung cancer patients. The inflammatory pathways that link chronic obstructive pulmonary disease, emphysema, and lung cancer likely involve genetic and epigenetic modulations due to chronic tissue injury and abnormal tumor immunity in susceptible hosts. Recent findings Chronic airway inflammation contributes to alterations in the bronchial epithelium and lung microenvironment, provoking a milieu conducive to pulmonary carcinogenesis. For example, inflammation-inducible cyclooxygenase-2 is upregulated in nonsmall cell lung cancer and also plays an important role in promoting epithelial-to-mesenchymal transition. Genetic changes in the airway epithelium of smokers may help predict or identify individuals at risk for lung cancer. Finally, radiographic findings of emphysema have been established as independent risk factors for lung cancer. Summary The relationships between inflammation, airflow obstruction, and lung cancer are complex. Deregulated inflammation is complicit in the pathogenesis of chronic obstructive pulmonary disease and lung cancer, but the overlap of signaling events is not yet fully understood. Tobacco exposure is an important risk factor that confers long-term risk of lung disease. Diagnostic sensitivity of detecting lung cancer may improve with the utilization of genetic profiling in combination with pathologic evaluation of airway epithelium. Additional research is required to understand the role of epithelial-to-mesenchymal transition in chronic inflammatory lung diseases and lung carcinogenesis.
Identification of Differentially Expressed Proteins in Liver in Response to Subacute Ruminal Acidosis (SARA) Induced by High-concentrate Diet

The aim of this study was to evaluate protein expression patterns of liver in response to subacute ruminal acidosis (SARA) induced by high-concentrate diet. Sixteen healthy mid-lactating goats were randomly divided into 2 groups and fed either a high-forage (HF) diet or a high-concentrate (HC) diet. The HC diet was expected to induce SARA. After ensuring the occurrence of SARA, liver samples were collected. Proteome analysis with differential in gel electrophoresis technology revealed that, 15 proteins were significantly modulated in liver in a comparison between HF and HC-fed goats. These proteins were found mainly associated with metabolism and energy transfer after identified by matrix-assisted laser desorption ionization/time of flight. The results indicated that glucose, lipid and protein catabolism could be enhanced when SARA occurred. It prompted that glucose, lipid and amine acid in the liver mainly participated in oxidation and energy supply when SARA occurred, which possibly consumed more precursors involved in milk protein and milk fat synthesis. These results suggest new candidate proteins that may contribute to a better understanding of the mechanisms that mediate liver adaptation to SARA.
Defining Genre and Gender in Latin Literature: Essays Presented to William S. Anderson on His Seventy-Fifth Birthday

The Roman confrontation and assimilation of Greek literature entailed a scrutiny, critique, and adaptation of generic assumptions. This book considers the ways in which major genres--among them comedy, lyric, elegy, epic, and the novel--were redefined to accommodate Roman concerns and the ways in which gender plays a role in generic definition and authorial self-definition. Both of these areas of research have been important to William S. Anderson throughout his career. This collection of essays by his students helps readers to understand the nature of Roman literary self-definition, as it honors Professor Anderson's own achievements in this field.
Human papillomavirus and cancerous diseases of the head and neck: a systematic review and meta-analysis.

The increasing incidence of head and neck cancer (HNSCC) highlights the need to better understand the role of human papillomavirus (HPV) in the development of these cancers. The aims of this study were to conduct a systematic review and a meta-analysis concerning observational studies on the association between HPV infection and HNSCC and to quantify this association, thereby obtaining a reliable estimation of the risk of HPV infection in the development of head and neck cancer. Literature searches were performed using PubMed and Scopus databases. StatsDirect 2.7. 8 program was used for the analysis. We found 15 case-control studies, 63 prevalence studies, and no cohort studies. The pooled odds ratio (OR) for all the included case-control studies resulted in a value of 1.63 (95% CI 1.27-2.09; P < 0.0001). The highest pooled OR resulted from the analysis of all the studies that examined HPV 16 genotype in association oral cavity (OR 5.36; 95% CI 1.4-20). The strong evidence of association between HPV infection and HNSCC highlights the importance of the introduction of specific tests in the cancer prevention practices to evaluate the presence of the virus, especially in the oral cavity, and the possibility of an extension of the vaccine anti-HPV in the male population too.
La pobreza de los internos de la cárcel de Chetumal, Quintana Roo, México

Las carceles siempre han sido pobladas por los mas pobres, por los que no tuvieron exito en el mercado laboral, el tema ahora es que esos presos pobres son tambien violentados por los grupos de la delincuencia organizada, que controlan las carceles mexicanas. La carcel de Chetumal, es una de las carceles donde mas se puede mirar la pobreza de los internos, de las peores evaluadas por la Comision Nacional de Derechos Humanos. Cuando conocemos de cerca las historias de los presos, podemos comprender como se construye la conducta criminal y reflexionar sobre como la prision sirve para reproducir la violencia y la pobreza bajo la mirada del poder
Intrauterine growth retardation, body size, body composition and physical performance in adolescence.

Studies about effects of IUGR on growth in childhood as well as on body size, body composition and physical performance in adolescence and adulthood are reviewed. The review is based on 12 studies that distinguished IUGR from other types of low birthweight and compared outcomes of IUGR cases with those of non-IUGR controls. This information is complemented by results of a follow-up study of IUGR cases and controls carried out in Guatemalan adolescents and young adults. In Guatemala as well as in other countries, IUGR newborns showed partial catch-up growth during the first one or two years of life, and then maintained their achieved place in the growth distribution. Guatemalan IUGR cases were shorter, lighter and weaker than non-IUGR controls as adolescents and young adults. The differences in adult body size observed in Guatemala between cases and controls are similar to those found in more affluent countries (i.e. about 5 cm in height and 5 kg in weight).
Reducing Anxiety Among Children Born Preterm and Their Young Mothers

Purpose: To examine the efficacy of COPE on maternal and child anxiety associated with younger mothers of premature infants. The COPE program provides instruction and practice in parenting behaviors specific to the NICU, in combination with information that reduces ambiguity about their infant's appearance and behaviors. Study Design and Methods: Secondary data analysis was conducted on data obtained from a larger randomized controlled trial with 253 mothers of low birthweight premature infants to examine the efficacy of the Creating Opportunities for Parent Empowerment (COPE) program, an educational–behavioral parent intervention in the NICU, on maternal and child anxiety based on maternal age. For these analyses, child and maternal anxiety were assessed using the Child Behavior Checklist for Ages 2 to 3 and the State-Trait Anxiety Inventory collected at 24 months and 2 to 4 days postintervention, respectively. To test study hypotheses, we conducted multiple regression models using the structural equation modeling approach to path analysis. Results: Multiple regression results for the full model indicated that there was a significant COPE × mothers' age interaction effect on both mothers' anxiety and child anxiety. Participation in the COPE program significantly predicted lower levels of mothers' anxiety at postintervention as well as lower levels of child anxiety at 24 months for younger mothers (18-21 years old), but not for mothers over 21 years old. Clinical Implications: Participating in COPE was associated with more favorable mental health outcomes for younger mothers and their children than mothers over 21 years old. Participation in the COPE program may help close the health disparities gap by improving behaviors in infants of younger mothers to rates similar to those of children of mothers over 21 years old.
Prognostic Factors in Ewing’s Sarcoma of the Foot

The outcome of treatment and prognostic factors were reviewed in 36 patients who had Ewing’s sarcoma of the foot. The tumor was most common in the calcaneus (19 patients) and metatarsals (15 patients). Age, levels of lactate dehydrogenase, degree of anemia, tumor volume, type of surgery, and radiotherapy were not related to prognosis. Females with pain for less than 6 months, fever, high levels of erythrocyte sedimentation rate, and high levels of alkaline phosphatase showed a tendency for a poorer prognosis. The only observed prognostic factors are tumor site and treatment. Patients treated with four-drug neoadjuvant chemotherapy had the best survival. Four patients with metastatic disease at diagnosis died. Fourteen of 32 patients (44%) with localized Ewing’s sarcoma were continuously disease-free at an average followup of 7 years.