Miracle-dz/UniFAR-FTUs huggingface dataset:
Direct and Indirect Costs of Asthma in School-age Children

Introduction Asthma is one of the most common chronic diseases of childhood and is the most common cause of school absenteeism due to chronic conditions. The objective of this study is to estimate direct and indirect costs of asthma in school-age children. Methods Using data from the 1996 Medical Expenditure Panel Survey, we estimated direct medical costs and school absence days among school-age children who had treatment for asthma during 1996. We estimated indirect costs as costs of lost productivity arising from parents’ loss of time from work and lifetime earnings lost due to premature death of children from asthma. All costs were calculated in 2003 dollars. Results In 1996, an estimated 2.52 million children aged five to 17 years received treatment for asthma. Direct medical expenditure was $1009.8 million ($401 per child with asthma), including payments for prescribed medicine, hospital inpatient stay, hospital outpatient care, emergency room visits, and office-based visits. Children with treated asthma had a total of 14.5 million school absence days; asthma accounts for 6.3 million school absence days (2.48 days per child with asthma). Parents’ loss of productivity from asthma-related school absence days was $719.1 million ($285 per child with asthma). A total of 211 school-age children died of asthma during 1996, accounting for $264.7 million lifetime earnings lost ($105 per child with asthma). Total economic impact of asthma in school-age children was $1993.6 million ($791 per child with asthma). Conclusion The economic impact of asthma on school-age children, families, and society is immense, and more public health efforts to better control asthma in children are needed.
Not-so-social learning strategies

Social learning strategies (SLSs) are rules specifying the conditions in which it would be adaptive for animals to copy the behaviour of others rather than to persist with a previously established behaviour or to acquire a new behaviour through asocial learning. In behavioural ecology, cultural evolutionary theory and economics, SLSs are studied using a ‘phenotypic gambit’—from a purely functional perspective, without reference to their underlying psychological mechanisms. However, SLSs are described in these fields as if they were implemented by complex, domain-specific, genetically inherited mechanisms of decision-making. In this article, we suggest that it is time to begin investigating the psychology of SLSs, and we initiate this process by examining recent experimental work relating to three groups of strategies: copy when alternative unsuccessful, copy when model successful and copy the majority. In each case, we argue that the reported behaviour could have been mediated by domain-general and taxonomically general psychological mechanisms; specifically, by mechanisms, identified through conditioning experiments, that make associative learning selective. We also suggest experimental manipulations that could be used in future research to resolve more fully the question whether, in non-human animals, SLSs are mediated by domain-general or domain-specific psychological mechanisms.
Effect of various neurotransmitters and electrical field stimulation on smooth muscle preparations from the esophagus of horses.

The effects of various neurotransmitters and electrical field stimulation on muscle strips from the distal equine esophagus were studied. Acetylcholine (ACH) caused concentration dependent (1.1-55 x 10(-6) mol/l) contractions of the longitudinal and circular muscle strips from the distal esophagus as well as from the lower esophageal sphincter (LES). Atropine (10(-5) mol/l) blocked these contractions. Noradrenaline (NA) induced concentration related (1.1-55 x 10(-6) mol/l) contractions of the muscle strips from the LES. This excitatory effect of noradrenaline was antagonized by the alpha 1-receptor antagonist prazosin. Tetrodotoxin (5 x 10(-6) mol/l) did not affect the contractile response of the muscle strips to noradrenaline (55 x 10(-6) mol/l). Noradrenaline (1.1-55 x 10(-6) mol/l) had no excitatory effect on the circular and the longitudinal muscle strips from the esophagus. Furthermore, noradrenaline induced a concentration dependent (1.1-55 x 10(-6) mol/l) relaxation of the longitudinal muscle strips from the esophagus. The relaxing effect of NA was antagonized by the beta-receptor antagonist propranolol (10(-5) mol/l). Histamine (10(-7)-10(-6) mol/l) elicited a contraction in 4 out of 18 muscle preparations from the LES. The histamine induced contractions were partly antagonized by the H1-receptor antagonist clemastine (10(-4) mol/l) and fully abolished by the H2-receptor antagonist clemastine (10(-4) mol/l). Electrical field stimulation (EFS, 5 Hz, 2 ms; 500 mA; 10 Hz, 2 ms; 500 mA) produced tetrodotoxin sensitive contractions in all three types of muscle strips. Atropine (10(-5) mol/l) fully suppressed these contractions in most preparations. (ABSTRACT TRUNCATED AT 250 WORDS)
Toxicity and Bioaccumulation of Heavy Metals in Spinach (Spinacia oleracea) Grown in a Controlled Environment

The impact of heavy metal toxicity on the shoot and root lengths, total protein, fiber characteristics, moisture content and nutrient composition of spinach (Spinacia oleracea) was evaluated. Plants were grown in pots containing soil and treated with different concentrations (mg/kg) of lead (Pb; 300, 400 and 500), cadmium (Cd; 0.5, 1 and 1.5) and zinc (Zn; 250, 500, and 700) as well as mixtures of Cd and Pb (0.5/300, 1/400, 1.5/500), Cd and Zn (0.5/250, 1/500, 1.5/700), and Pb and Zn (300/250, 400/500, 500/700). Soil contaminated by long-term irrigation with wastewater containing heavy metals was simulated. An increase in concentrations of heavy metals both individually and as mixtures significantly (p < 0.05) reduced the growth parameters and nutrient contents of S. oleracea. The uptake patterns of heavy metals in mixtures showed antagonistic impacts on each other. The toxicities of the mixtures Cd and Pb, Cd and Zn as well as Pb and Zn were higher than those observed in separate heavy metal applications but less than their additive sums. The toxicity caused by individual heavy metals was the highest for Cd followed by Pb and Zn. The highest toxicity was observed in plants grown in soil contaminated by Cd and Pb.
Novel Insights into E. coli’s Hexuronate Metabolism: KduI Facilitates the Conversion of Galacturonate and Glucuronate under Osmotic Stress Conditions

Using a gnotobiotic mouse model, we previously observed the upregulation of 2-deoxy-D-gluconate 3-dehydrogenase (KduD) in intestinal E. coli of mice fed a lactose-rich diet and the downregulation of this enzyme and of 5-keto 4-deoxyuronate isomerase (KduI) on a casein-rich diet. The present study aimed to define the role of the so far poorly characterized E. coli proteins KduD and KduI in vitro. Galacturonate and glucuronate induced kduD and kduI gene expression 3-fold and 7 to 11-fold, respectively, under aerobic conditions as well as 9 to 20-fold and 19 to 54-fold, respectively, under anaerobic conditions. KduI facilitated the breakdown of these hexuronates. In E. coli, galacturonate and glucuronate are normally degraded by UxaABC and UxuAB. However, osmotic stress represses the expression of the corresponding genes in an OxyR-dependent manner. When grown in the presence of galacturonate or glucuronate, kduID-deficient E. coli had a 30% to 80% lower maximal cell density and 1.5 to 2-fold longer doubling times under osmotic stress conditions than wild type E. coli. Growth on lactose promoted the intracellular formation of hexuronates, which possibly explain the induction of KduD on a lactose-rich diet. These results indicate a novel function of KduI and KduD in E. coli and demonstrate the crucial influence of osmotic stress on the gene expression of hexuronate degrading enzymes.
Factors affecting sediment trapping in vegetated filter strips: simulation study using VFSMOD

Soil and water conservation practices have been promoted for a long time, in order to sustain agricultural activities and prevent environmental pollution. Vegetated filter strips (VFS) have been used to reduce sediment pollution into water bodies at or near the pollutant source. However, factors effecting VFS performance under natural conditions have not been well understood owing to the physical, time and financial limitations of field experiments. The use of well‐validated simulation models to understand the performance of VFS and factors affecting sediment deposition is highly justified. The objective of this research is to investigate sediment trapping in VFS and to study various factors affecting VFS performance using the simulation model VFSMOD, which was developed by researchers at University of North Carolina. Recently, VFSMOD has been validated successfully by using 21 filters with varying length, slope and vegetated cover. A wide range of five parameters was selected for the simulations, namely filter length, filter slope, manning roughness coefficient, soil type and characteristics of incoming sediment from adjacent fields. Computer simulations revealed that the length of filter is the most significant factor affecting sediment trapping in VFS. The relative increase in trapping efficiencies was not linearly related to an increase in filter length. Inflow sediment class also has a major influence on sediment trapping in VFS. The trapping efficiency of clay sediments in a 15 m length VFS was 47% compared with 92% for silt from incoming sediment. Manning roughness coefficient had a moderate effect on sediment trapping and was more significant in short filters. Land slope and soil type of VFS had a minor influence on the performance of VFS. Copyright © 2001 John Wiley & Sons, Ltd.
What's Wrong with Moore's Argument?

1 Some Diagnoses Moore looked at his hands and argued: (1) Here are two hands. (2) If hands exist, then there is an external world. (3) So there is an external world. 1 Something about this argument sounds funny. As we'll see, though, it takes some care to identify exactly what Moore has done wrong. I will assume that Moore knows premise (2) to be true. One could inquire into how he knows it, and whether that knowledge can be defeated; but I won't. I'll focus instead on what epistemic relations Moore has to premise (1) and to his conclusion (3). It may matter which epistemic relations we choose to consider. Some philosophers will diagnose Moore's argument using Contextualist machinery. They'll say: In some contexts, it'd be true to count Moore as knowing he has hands and that there is an external world. In more restrictive contexts, it would not. Moore's argument sounds funny because Moore plays fast and loose with the context. His straightforward assertion ''Here are two hands'' invites us to occupy a lax context; but one would only be concerned to argue that there's an external world in a more restrictive context, where the existence of the external world is an open question. If these philosophers are right to count 'knows' as context-sensitive, 2 then they're probably right in their complaint that Moore's performance plays
Empirical Prediction of Leaf Area Index (LAI) of Endangered Tree Species in Intact and Fragmented Indigenous Forests Ecosystems Using WorldView-2 Data and Two Robust Machine Learning Algorithms

Leaf area index (LAI) is an important biophysical trait for forest ecosystem and ecological modeling, as it plays a key role for the forest productivity and structural characteristics. The ground-based methods like the handheld optical instruments for predicting LAI are subjective, pricy and time-consuming. The advent of very high spatial resolutions multispectral data and robust machine learning regression algorithms like support vector machines (SVM) and artificial neural networks (ANN) has provided an opportunity to estimate LAI at tree species level. The objective of the this study was therefore to test the utility of spectral vegetation indices (SVI) calculated from the multispectral WorldView-2 (WV-2) data in predicting LAI at tree species level using the SVM and ANN machine learning regression algorithms. We further tested whether there are significant differences between LAI of intact and fragmented (open) indigenous forest ecosystems at tree species level. The study shows that LAI at tree species level could accurately be estimated using the fragmented stratum data compared with the intact stratum data. Specifically, our study shows that the accurate LAI predictions were achieved for Hymenocardia ulmoides using the fragmented stratum data and SVM regression model based on a validation dataset (R2Val = 0.75, RMSEVal = 0.05 (1.37% of the mean)). Our study further showed that SVM regression approach achieved more accurate models for predicting the LAI of the six endangered tree species compared with ANN regression method. It is concluded that the successful application of the WV-2 data, SVM and ANN methods in predicting LAI of six endangered tree species in the Dukuduku indigenous forest could help in making informed decisions and policies regarding management, protection and conservation of these endangered tree species.
Analysis of Multiple Precipitation Products and Preliminary Assessment of Their Impact on Global Land Data Assimilation System Land Surface States

Abstract Precipitation is arguably the most important meteorological forcing variable in land surface modeling. Many types of precipitation datasets exist (with various pros and cons) and include those from atmospheric data assimilation systems, satellites, rain gauges, ground radar, and merged products. These datasets are being evaluated in order to choose the most suitable precipitation forcing for real-time and retrospective simulations of the Global Land Data Assimilation System (GLDAS). This paper first presents results of a comparison for the period from March 2002 to February 2003. Later, GLDAS simulations 14 months in duration are analyzed to diagnose impacts on GLDAS land surface states when using the Mosaic land surface model (LSM). A comparison of seasonal total precipitation for the continental United States (CONUS) illustrates that the Climate Prediction Center (CPC) Merged Analysis of Precipitation (CMAP) has the closest agreement with a CPC rain gauge dataset for all seasons except winter.
Dermal Changes in the Lower Leg Skin of Patients With Venous Hypertension

Patients with chronic venous disease may develop characteristic changes in the skin of the lower limb known as lipodermatosclerosis (LDS). The affected skin becomes indurated and pigmented and often ulcerates. The degree of induration associated with LDS correlates directly with ulcer formation and leads to a subsequent delayed rate of healing. However, there is limited information regarding the cellular and molecular events that lead from venous dysfunction to LDS development. This article reviews the current knowledge of the clinical progression of chronic venous disease, summarizing the histological findings from these authors’ laboratory and other studies on LDS, and offers possible mechanisms to explain the fibrotic changes associated with this condition.
Genetic and antigenic characterization of a serotype P[6]G9 human rotavirus strain isolated in the United States.

During an epidemiologic survey of rotavirus infections established to monitor the prevalent G serotypes circulating in the United States, human P[6]G9, subgroup I rotavirus strains causing symptomatic infections were identified as the fourth most common serotype. In this report we describe the molecular and antigenic characterization of one of these P[6]G9 isolates (US1205). Neutralization and sequencing studies have demonstrated that both outer capsid proteins, VP7 and VP4, of US1205 are closely related to but genetically and antigenically distinguishable from those of standard G9 strains (e.g., F45, WI61) and standard P2A[6] strains (e. g., ST3, M37). Thus the complete antigenic type of US1205 is P2A[6]G9, subgroup I. Sequence analysis of the VP6 and NSP4 genes of US1205 indicates that strain US1205 possessed VP6 subgroup I and NSP4A genotype specificities. Finally, Northern hybridization studies suggest that the P[6]G9 strains are closely related to members of the DS-1 genogroup except for their P[6] VP4 gene, which has been commonly identified in strains of both major human genogroups, and their G9 VP7 gene, which may have been derived by reassortment with a Wa genogroup strain. Examination of historic collections and prospective surveillance of strains will be needed to determine whether this strain has been present for some time or if it is emerging to compete with the other common serotypes of rotavirus.
Reduction of water permeability by anisotonic solutions in frog corneal epithelium.

PURPOSE To study the effects of bathing solution osmolarity and Cl- secretagogues on the diffusional water permeability (Pdw) of the isolated frog corneal epithelium. METHODS Isolated frog corneas, with the endothelium scraped off, were mounted as a partition between Ussing-type hemichambers. Unidirectional diffusional water fluxes (Jdw) were measured by adding 3H2O to one hemichamber and sampling from the other. Electrical parameters were measured simultaneously. Jdw was determined in control isosmotic conditions and after either changes in osmolarity of the bathing solutions or the additions of amphotericin B, epinephrine, Ca2+ ionophore, and other agents. RESULTS Apical addition of 0.5 mM HgCl2 elicited an 11-fold increase in paracellular conductance and inhibited Jdw by 36%, suggesting that Jdw was predominantly transcellular and that there was a negligible contribution of the paracellular pathway. Pretreatment of corneas with 2-mercaptoethanol prevented the effects of Hg2+ on the paracellular conductance and Jdw. A hypotonic medium on the basolateral side reversibly reduced Jdw proportionately to the reduction in osmolarity, with 40 mOsm exerting a 29% decrease. Results from an Arrhenius plot suggest that water channels closed under this condition. Apical hypertonicity (350 mOsm) reduced Jdw by approximately 12%. Basolateral hypertonicity (450 mOsm), after permeabilization of the apical membrane with amphotericin B, reduced Jdw by 15%. Epinephrine was the only Cl- secretagogue that reduced Jdw, on average by 12%. This effect, which was also observed with amphotericin B-treated corneas, was not mediated by classical beta-receptors based on the results obtained with isoproterenol and propranolol. CONCLUSIONS Changes in basolateral osmolarity or the presence of an apical hypertonic solution decreased the diffusional water permeability (Pdw) of the corneal epithelium. Epinephrine also decreased Pdw, and this effect was localized to the basolateral membrane. The similarities, of a sequence motif found in potassium channels and beta-adrenergic receptor kinases that are regulated by the beta gamma subunit of G proteins with that found in aquaporins 2 and 5, could explain the link with epinephrine. Regardless of the mechanism, these results indicate that corneal epithelial water permeability can be regulated, presumably to protect cell volume from changes in solution osmolarity.
Classifying search queries using the Web as a source of knowledge

We propose a methodology for building a robust query classification system that can identify thousands of query classes, while dealing in real time with the query volume of a commercial Web search engine. We use a pseudo relevance feedback technique: given a query, we determine its topic by classifying the Web search results retrieved by the query. Motivated by the needs of search advertising, we primarily focus on rare queries, which are the hardest from the point of view of machine learning, yet in aggregate account for a considerable fraction of search engine traffic. Empirical evaluation confirms that our methodology yields a considerably higher classification accuracy than previously reported. We believe that the proposed methodology will lead to better matching of online ads to rare queries and overall to a better user experience.
Statistical properties of the haplotype relative risk

In the haplotype relative risk (HRR) statistic (Rubinstein et al.: Human Immunol 3:384 [abstract], 1981), a disease sample is constructed along with its own internal control by comparing those marker alleles passed from the parents to an affected child with the other parental marker alleles not transmitted. Based on the conditional parental genotype distribution given that they have an affected child, statistical properties of the HRR statistic are derived. It is shown that the HRR is different from 1 only when allelic association is present and the recombination fraction is different from 1/2. Transmitted and nontransmitted marker alleles are shown to be statistically independent only in the absence of either allelic association or recombination.
Normal faulting on Sifnos and the South Cycladic Detachment System, Aegean Sea, Greece

Abstract: We constrain the timing and kinematics of normal faulting on Sifnos, Cyclades, Greece. Penetrative top-to-the-NE kinematic indicators associated with a shallow dipping foliation occur in the deepest tectonic unit (Greenschist Unit). Combined P–T analysis and Rb–Sr dating indicates that this deformation was under way by 29.4 ± 3.4 Ma at P–T conditions of c. 16 kbar and c. 550 °C, and continued to operate at least until 22.8 ± 0.2 Ma at P–T conditions of c. 8 kbar and c. 400 °C. The later top-to-the-south directed Sifnos Detachment developed at the top of the Greenschist Unit and cuts the top-to-the-NE structures. Zircon fission-track ages suggest that deformation on the Sifnos Detachment was largely terminated by about 13–10 Ma. Subsequent extension was accommodated by high-angle normal faults. Regionally the top-to-the-south detachment phase on Sifnos correlates with top-to-the-south extensional faulting on nearby Serifos, which started there at c. 15–13 Ma. Top-to-the-south extensional shearing on Ios to the SE commenced earlier at c. 19–18 Ma, suggesting that top-to-the-south extension propagated westward from Ios to Sifnos and Serifos, or that extension was partitioned into different top-to-the-south detachment systems that operated at different times. Collectively these top-to-the-south detachments are named here the South Cycladic Detachment System, which played a key role in the opening of the Cretan Sea forearc basin.
Perinatal morbidity and early neonatal mortality in twin pregnancies

Purpose: The purpose of this study was to investigate the impact of maternal, fetal and obstetric parameters in twin pregnancies due to chorionicity, perinatal morbidity and early neonatal mortality. Methods: Early neonatal outcome parameters were retrospectively analysed in 240 twin pregnancies (51 monochorionic [MC], 189 dichorionic [DC] twins) over a 7.5 years period. Beside chorionicity, we focused on risk factors affecting perinatal morbidity and early neonatal outcome in the overall study cohort and subgroups 1) late preterm and 2) pregnancies conceived by artificial fertilization (IVF/ICSI). Mixed effects logistic regression models were used for multivariate risk analyses. Results: MC vs DC pregnancies showed significantly lower birth weights (p 25% and amniotic inflammation (amniotic infection syndrome [AIS]). A gestational age >36 completed weeks was accompanied by a decrease of early neonatal complications (p
Monitoring the evolution of permafrost in the Tien Shan

The extent and altitudinal range of permafrost in the Tien Shan has changed many times during the Holocene. The lower limit of permafrost has risen significantly, but from time to time it has regressed. For example, the limit of permafrost during the Little Ice Age was lower than it is now by about 300–400 m. Based on the distribution of relict permafrost features in the Tien Shan, the mean annual air temperature in the Little Ice Age was 2–3°C lower than today. During the last years, permafrost temperatures have increased 0.1 to 0.4°C.