Miracle-dz/UniFAR-FTUs huggingface dataset:
A processing scheme for time-variant phase analysis in EEG burst activity of premature and full-term newborns in quiet sleep: a methodological study

Abstract A processing scheme for the investigation of neonatal electroencephalographic burst oscillations that is composed of time-variant methods for linear and nonlinear phase analysis is introduced. Starting from a time-frequency analysis of oscillations’ amplitudes, time-variant approaches for quantification of phase locking, n:m phase synchronization, and quadratic phase coupling are applied. Tracé discontinue patterns from premature newborns and tracé alternant patterns from full-term newborns were investigated using bipolar EEG recordings. Maturation-related differences between the burst generation mechanisms can be shown, which are reflected in group-specific patterns of augmentation, timing, and grouping of time-varying phase characteristics of the EEG burst oscillations. We demonstrate for both groups (premature and full-term newborns) that phase-locked low-frequency oscillations are pronounced in the frequency range of 0.5–1.5 Hz. Phase-locked oscillations also occur in a frequency range of >3 Hz. The amplitude of a phase-locked 2-Hz oscillation is higher in full-term than in premature newborns. After onset, n:m synchronization and an increase in bicoherence occur earlier in the premature group (between 0.5–1.5 Hz and 3.0–6.0 Hz). It can be suggested that during the maturation process, the driving force of thalamic structures decreases and that cortical activity plays an increasingly important role in the process of burst generation.
Pulmonary , gastrointestinal and urogenital pharmacology Physcion induces mitochondria-driven apoptosis in colorectal cancer cells via downregulating EMMPRIN

Physcion, an anthraquinone derivative widely isolated and characterized from both terrestrial and marine sources, has anti-tumor effects on a variety of carcinoma cells, mainly through inhibition of cell proliferation, apoptosis induction and cell cycle arrest. However, little is known about the mechanisms underlying its role in tumor progression. In the present study, we investigated the molecular mechanisms involved in physcion-induced apoptosis in human colorectal cancer (CRC) lines HCT116. Our results showed that physcion inhibited tumor cell viability in a doseand time-dependent manner, and induced cell apoptosis via intrinsic mitochondrial pathway. Our results also revealed that physcion treatment significantly inhibited extracelluar matrix metalloproteinase inducer (EMMPRIN) expression in HCT116 cells in a dose-dependent manner and overexpression of EMMPRIN protein markedly reduced physcioninduced cell apoptosis. Furthermore, our results strongly indicated the modulating effect of physcion on EMMPRIN is correlated with AMP-activated protein kinase (AMPK)/Hypoxia-inducible factor 1α (HIF-1α) signaling pathway. Our data provide the first experimental evidence that physcion induces mitochondrial apoptosis in CRC cells by downregulating of EMMPRIN via AMPK/HIF-1α signaling pathway and suggest a new mechanism to explain its anti-tumor effects. & 2015 Published by Elsevier B.V.
Characterization, Distribution, and Expression of Novel Genes among Eight Clinical Isolates of Streptococcuspneumoniae

ABSTRACT Eight low-passage-number Streptococcus pneumoniae clinical isolates, each of a different serotype and a different multilocus sequence type, were obtained from pediatric participants in a pneumococcal vaccine trial. Comparative genomic analyses were performed with these strains and two S. pneumoniae reference strains. Individual genomic libraries were constructed for each of the eight clinical isolates, with an average insert size of ∼1 kb. A total of 73,728 clones were picked for arraying, providing more than four times genomic coverage per strain. A subset of 4,793 clones were sequenced, for which homology searches revealed that 750 (15.6%) of the sequences were unique with respect to the TIGR4 reference genome and 263 (5.5%) clones were unrelated to any available streptococcal sequence. Hypothetical translations of the open reading frames identified within these novel sequences showed homologies to a variety of proteins, including bacterial virulence factors not previously identified in S. pneumoniae. The distribution and expression patterns of 58 of these novel sequences among the eight clinical isolates were analyzed by PCR- and reverse transcriptase PCR-based analyses, respectively. These unique sequences were nonuniformly distributed among the eight isolates, and transcription of these genes in planktonic cultures was detected in 81% (172/212) of their genic occurrences. All 58 novel sequences were transcribed in one or more of the clinical strains, suggesting that they all correspond to functional genes. Sixty-five percent (38/58) of these sequences were found in 50% or less of the clinical strains, indicating a significant degree of genomic plasticity among natural isolates.
Using short vignettes to disentangle perceived capability from motivation: a test using walking and resistance training behaviors

Self-efficacy is arguably the strongest correlate of physical activity, yet some researchers suggest this is because the construct confounds ability with motivation. We examine a more circumscribed construct, called perceived capability (PC), meant to measure ability but not motivation and propose that the construct will not be related to unskilled physical activities but may be linked to skilled behaviors. The purpose of this paper was to examine whether a PC construct can be stripped of motivation using a vignette approach in both walking and resistance training behaviors. Participants were a random sample of 248 university students, who were then randomly assigned to either answer resistance training or walking behavior questions. Both groups completed a PC measure and reasons for their answer before and after reading a vignette that clarified the phrasing of capability to a literal use of the term. PC was significantly (p < .01) higher post- compared to pre-vignette and the differences were greater (p < .01) for walking than for resistance training. PC had significantly (p < .01) smaller correlations with intention and self-reported behavior post-disambiguation, which resulted in a null relationship with walking but a small correlation with resistance training behavior. When PC was combined with intention to predict behavior, however, there was no significant (p > .05) difference in the amount of variance explained pre- to post-vignette. Thought listing showed that participants did not report capability barriers to walking and over half of the sample construed capability as motivation/other priorities pre-vignette. The findings support use of a vignette approach for researchers who wish to disentangle the assessment of PC from motivation while creating no overall loss in explained variance of physical activity.
Response of Soybean to Fertilizer Levels in Northern Dry Zone of Karnataka, India

Vegetable soybean has excellent potential for enriching the human diet. Vegetable soybean is rich in protein (13%), cholesterol-free fatty acids (57%), TSS (6.5%), phosphorus (158 mg/100g), calcium (78 mg/100 g), It is a good source of carbohydrate and iron rich source of vitamin A, vitamin B1 (0.4 mg/100g) and vitamin B2 (0.17 mg/100g). In addition it is a natural source of iso-flavones and tocopherols. The nutritional value and protein content is an important characteristic of vegetable soybean, which is superior to the meat, cow milk and eggs. Vegetable soybean provides more protein of higher quality and is considered as excellent protein source compared to vegetable pigeon pea and green peas protein. In addition to domestic consumption, vegetable soybean also has export potential. Vegetable soybean pods are harvested at the completely seed filled stage while pods and plants are still green.
Personality Traits and Social Desirability as Predictors of Subjective Well-being

The aim of this study was to examine the relationship between personality traits, social desirability and subjective well-being. A total of 392 students (195 females and 197 males), aged 19 to 26 years (M=20.25, SD=1.46) completed the Satisfaction with Life Scale, PANAS, Marlowe-Crowne Social Desirability Scale and measures of the Big Five personality dimensions (IPIP50). Hierarchical regression analyses were performed with personality traits and social desirability as predictors and subjective well-being components (satisfaction with life, positive and negative affects) as dependent variables. The results confirmed previous findings that personality, specifically extraversion, emotional stability and conscientiousness, represent strong predictors of subjective well-being. Unlike in other studies, Intellect significantly predicted positive affect and Agreeableness showed additional significant prediction of absence of negative affect. When entered independently into the analysis, social desirability was a significant predictor of all three subjective well-being components. In combination with personality traits, social desirability showed association only with absence of negative affect which can be explained by the links between social desirability and personality traits. These findings indicate that relationship between social desirability, personality traits and subjective well-being is more complex than previous studies suggest. Social desirability appears to be a variable that together with personality traits provides additional explanation of subjective well-being.
A novel vascular pattern promotes metastasis of hepatocellular carcinoma in an epithelial–mesenchymal transition–independent manner

Early metastasis is responsible for frequent relapse and high mortality of hepatocellular carcinoma (HCC), but its underlying mechanisms remain unclear. Epithelial–mesenchymal transition (EMT) has been considered a key event in metastasis. Based on histological examination of serial HCC sections and three‐dimensional reconstruction, we found a novel and prevalent vascular pattern, vessels that encapsulated tumor clusters (VETC) and formed cobweb‐like networks. The presence of VETC (VETC+) predicted higher metastasis and recurrence rates of HCC. Using clinical samples and mouse xenograft models, we further showed that VETC was composed of functional vessels with blood perfusion and induced by tumor cells at the early stage of HCC. Subsequent investigations revealed that HCC cell–derived angiopoietin‐2 was a prerequisite for VETC formation and that the VETC pattern was a critical factor promoting HCC metastasis as knockdown of angiopoietin‐2 abolished this vascular pattern and consequently attenuated in vivo tumor metastasis. Interestingly, abrogation of EMT by knockdown of Snail or Slug significantly diminished in vivo metastasis of VETC– xenografts but did not affect that of VETC+ ones, although silencing of Snail or Slug substantially reduced the in vitro migration of both VETC+ and VETC– HCC cells. In contrast to human VETC– cases, EMT signatures were rarely observed in VETC+ cases with metastatic potential. Further analysis revealed that VETC provided an efficient metastasis mode by facilitating the release of whole tumor clusters into the bloodstream. Conclusion: Our findings identify a novel metastasis mechanism that relies on vascular pattern but is independent of EMT, which may provide new targets for antimetastasis therapy and offer a basis for selecting patients who may benefit from certain molecularly targeted drugs. (Hepatology 2015;62:452–465
Pharmacokinetics and Bioavailability of the Anti-Human Immunodeficiency Virus Nucleotide Analog 9-[(R)2-(Phosphonomethoxy)Propyl]Adenine (PMPA) in Dogs

ABSTRACT The pharmacokinetics, bioavailability, and metabolism of the anti-human immunodeficiency virus nucleotide analog 9[(R)-2-(phosphonomethoxy)propyl]adenine (PMPA) were determined in beagle dogs following intravenous, intraperitoneal, and oral administration. Fasted male beagle dogs (n = 5) were pretreated with pentagastrin and received PMPA (10 mg/kg of body weight) by the intravenous and oral routes with a washout period of 1 week between doses. A further group of male dogs received PMPA as a single dose via the intravenous (1 mg/kg; n = 5) and the intraperitoneal (10 mg/kg; n = 3) routes, with 1-week washout period between doses. The concentrations of PMPA in plasma and urine were determined over 48 h postdosing by fluorescence derivatization and high-performance liquid chromatography (HPLC). The potential for metabolism or biliary excretion of PMPA was evaluated in a dog with a chronic indwelling bile cannula. Urine, feces, and bile were collected at intervals over 48 h following the intravenous administration of [14C]PMPA (10 mg/kg; 55 μCi/kg). The concentrations of PMPA in plasma after intravenous injection were best described by an open two-compartment model with a terminal half-life of approximately 10 h. PMPA was excreted unchanged in urine (70%); recovery in feces (0.42%) or bile (0.26%) was negligible. The plasma clearance of PMPA (0.28 ± 0.05 liter/h/kg) was substantially greater than the glomerular filtration rate in this species, suggesting active tubular secretion of PMPA. No metabolites of [14C]PMPA were observed in urine, feces, or bile on the basis of HPLC with radioactive flow detection. The remainder of the dose was probably excreted unchanged in urine beyond 48 h postdosing. The mean ± standard deviation observed bioavailabilities of PMPA following oral and intraperitoneal administration at 10 mg/kg were 17.1% ± 1.88% and 73.5% ± 10.5%, respectively.
MULTI-EPOCH IMAGING POLARIMETRY OF THE SiO MASERS IN THE EXTENDED ATMOSPHERE OF THE MIRA VARIABLE TX CAM

We present a time series of synoptic images of the linearly polarized v = 1, J = 1–0 SiO maser emission toward the Mira variable, TX Cam. These data comprise 43 individual epochs at an approximate biweekly sampling over an optical pulsation phase range of ϕ = 0.68 to ϕ = 1.82. The images have an angular resolution of ∼500 μas and were obtained using the Very Long Baseline Array (VLBA), operating in the 43 GHz band in spectral-line, polarization mode. We have previously published the total intensity time series for this pulsation phase range; this paper serves to present the linearly polarized image sequence and an associated animation representing the evolution of the linear polarization morphology over time. We find a predominantly tangential polarization morphology, a high degree of persistence in linear polarization properties over individual component lifetimes, and stronger linear polarization in the inner projected shell than at larger projected shell radii. We present an initial polarization proper motion analysis examining the possible dynamical influence of magnetic fields in component motions in the extended atmospheres of late-type, evolved stars.
Specifications of Raw Olive Pomace as an Energy Source: A Statistical Approach

The present article is concerned with providing statistics-based specifications for raw olive pomace in Jordan. These specifications, together with other quantitative data pertaining to the last few olive harvest seasons, were believed to be essential for recognizing the relevance of raw olive pomace (jift) as a valuable renewable energy source in Jordan. Calculations based on average annual production of raw olive pomace, net calorific values, and the 2017 summer prices of raw olive pomace, diesel, and kerosene had shown that about thirteen million USD can be saved when raw olive pomace is combusted for heat generation instead of diesel or kerosene. The raw olive pomace samples used in the present work were collected over five olive harvest seasons, (2006, 20082011). The replicates of several measured characteristic properties of raw olive pomace were treated as one data set for deriving olive pomace specifications based on sound statistical analysis. The main results of the statistical analysis are those concerned with the 95% confidence intervals of the populations’ means of several raw olive pomace characteristics. The results obtained on dry basis are: 3.070 ± 0.170, 1.079 ± 0.125, 6.787 ± 0.306, 52.322 ± 1.171, and 35.271 ± 1.115% for the percentages of ash, nitrogen, hydrogen, carbon, and oxygen, respectively. Also, the gross and net calorific values were found to be 22.269 ± 0.793 and 20.542 ± 0.795 MJ/Kg, respectively. The estimated 95% confidence interval of a population mean was assumed to represent the upper and lower limits of a given property of the raw olive pomace. The findings of the present work will be considered for developing standard specifications for raw olive pomace in Jordan. Original Research Article Tawarah; CSIJ, 22(1): 1-20, 2018; Article no.CSIJ. 40045 2
The Effect of Fluoride on the Developing Tooth

This review aims to outline the effects of fluoride on the biological processes involved in the formation of tooth tissues, particularly dental enamel. Attention has been focused on mechanisms which, if compromised, could give rise to dental fluorosis. The literature is extensive and often confusing but a much clearer picture is emerging based on recent more detailed knowledge of odontogenesis. Opacity, characteristic of fluorotic enamel, results from incomplete apatite crystal growth. How this occurs is suggested by other changes brought about by fluoride. Matrix proteins, associated with the mineral phase, normally degraded and removed to permit final crystal growth, are to some extent retained in fluorotic tissue. Fluoride and magnesium concentrations increase while carbonate is reduced. Crystal surface morphology at the nano-scale is altered and functional ameloblast morphology at the maturation stage also changes. Fluoride incorporation into enamel apatite produces more stable crystals. Local supersaturation levels with regard to the fluoridated mineral will also be elevated facilitating crystal growth. Such changes in crystal chemistry and morphology, involving stronger ionic and hydrogen bonds, also lead to greater binding of modulating matrix proteins and proteolytic enzymes. This results in reduced degradation and enhanced retention of protein components in mature tissue. This is most likely responsible for porous fluorotic tissue, since matrix protein removal is necessary for unimpaired crystal growth. To resolve the outstanding problems of the role of cell changes and the precise reasons for protein retention more detailed studies will be required of alterations to cell function, effect on specific protein species and the nano-chemistry of the apatite crystal surfaces.
Interplay of electron correlations and lattice distortions in transition metal coordination compounds

of Dissertation In transition metal compounds with octahedral geometry, symmetry breaking effects play a key role in many spectroscopic phenomena in the physics and chemistry of these materials. An understanding of the links between octahedral coordination and how it impacts the electronic and magnetic structures of these materials is of key importance in this connection. With this motivation, I invoke first-principles methods to analyze electronic structures and spectroscopies of novel functional materials that show unique interplay of octahedral distortion, magnetism, electron correlation and spin orbit coupling effects. Specifically, this thesis deploys theoretical and computational methodologies to interpret spectral response of various experimental probes such as Compton scattering, x-ray absorption (XAS), x-ray emission (XES) and angle-resolved photoemission spectroscopy (ARPES), where electronic structure, electron correlation, spin-orbit coupling, and matrix element effects are considered in material-specific detail. The thesis first presents the electronic structure and ARPES spectroscopy of 5d transition metal iridates. When doped with carriers, these Mott insulators show a rich variety of phases and provide a playground to investigate the universalities of many exotic phenomena observed in 3d and 4dMott insulators. The thesis discusses the unconventional Fermi surface topology of iridates where Fermi arcs and Fermi pockets can be observed due to the competition between lattice distortion, electron correlations and spin-orbit coupling. Iridates also harbor a unique electronic anomaly called negative electronic compressibility (NEC). The first-principles study and the corresponding ARPES spectroscopy presented in this thesis demonstrate the signature of NEC for the first time in a quasi-three dimensional strongly correlated metal. The second part of the thesis focuses on the study of Li-ion battery (LIB) cathodes. High energy x-ray Compton scattering spectra along with parallel first-principles computations have been used to develop advanced spectroscopic tools for characterizing LIB cathodes such as lithium iron phosphate (LFP) and lithium manganese oxides (LMO). Our electronic
Research and implementation of four-prime RSA digital signature algorithm

Big module RSA signature algorithm is very popular these years. We try to improve it and get more operation efficiency. We proposed a four-prime Chinese Remainder Theorem (CRT)-RSA digital signature algorithm in this paper. We used the Hash function SHA512 to make message digest. We optimized large number modular exponentiation with CRT combining in Montgomery algorithm. Our experiment shows that our method got good performance. The security analysis shows higher signature efficiency on resistance of common attacks.
Isolation of an Intertypic Poliovirus Capsid Recombinant from a Child with Vaccine-Associated Paralytic Poliomyelitis

ABSTRACT The isolation of a capsid intertypic poliovirus recombinant from a child with vaccine-associated paralytic poliomyelitis is described. Virus 31043 had a Sabin-derived type 3-type 2-type 1 recombinant genome with a 5′-end crossover point within the capsid coding region. The result was a poliovirus chimera containing the entire coding sequence for antigenic site 3a derived from the Sabin type 2 strain. The recombinant virus showed altered antigenic properties but did not acquire type 2 antigenic characteristics. The significance of the presence in nature of such poliovirus chimeras and the consequences for the current efforts to detect potentially dangerous vaccine-derived poliovirus strains are discussed in the context of the global polio eradication initiative.
Immunotherapy for Alzheimer’s disease: past, present and future

Alzheimer’s disease (AD) is an incurable, progressive, neurodegenerative disorder affecting over 5 million people in the US alone. This neurological disorder is characterized by widespread neurodegeneration throughout the association cortex and limbic system caused by deposition of Aβ resulting in the formation of plaques and tau resulting in the formation of neurofibrillary tangles. Active immunization for Aβ showed promise in animal models of AD; however, the models were unable to predict the off-target immune effects in human patients. A few patients in the initial trial suffered cerebral meningoencephalitis. Recently, passive immunization has shown promise in the lab with less chance of off-target immune effects. Several trials have attempted using passive immunization for Aβ, but again, positive end points have been elusive. The next generation of immunotherapy for AD may involve the marriage of anti-Aβ antibodies with technology aimed at improving transport across the blood-brain barrier (BBB). Receptor mediated transport of antibodies may increase CNS exposure and improve the therapeutic index in the clinic.