Miracle-dz/UniFAR-FTUs huggingface dataset:
Mapping the Policy Landscape of Australian Early Childhood Education Policy through Document Analysis

WHILE MUCH HAS BEEN written about recent reforms in Australian early childhood education (birth to five) policy, less attention has been directed towards the changes across the whole early childhood period (birth to eight) and potential links between policy covering the prior-to-school and early school years. The near-concurrent introduction of two national curriculum documents covering these sectors has provided opportunities to explore such links. Recognising that such national approaches do not emerge from a vacuum, we identified a wide range of additional documents that contributed to the history, development, implementation and evaluation of the national curriculum documents, with the aim of exploring the links across these and the policy imperatives guiding these. Qualitative Document Analysis was used to manage the overwhelming number of related documents that were identified. In this paper, we share the processes used in the descriptive coding of a large corpus of documents, and reflect on the advantages and challenges encountered. We share these reflections not only as a means of contributing to discussions about the nature and impact of early childhood policy, but also to provide a transparent basis for future analyses.
In vivo Bioluminescence Imaging of Burkholderia mallei Respiratory Infection and Treatment in the Mouse Model

Bioluminescent imaging (BLI) technology is a powerful tool for monitoring infectious disease progression and treatment approaches. BLI is particularly useful for tracking fastidious intracellular pathogens that might be difficult to recover from certain organs. Burkholderia mallei, the causative agent of glanders, is a facultative intracellular pathogen and has been classified by the CDC as a Category B select agent due to its highly infectious nature and potential use as a biological weapon. Very little is known regarding pathogenesis or treatment of glanders. We investigated the use of bioluminescent reporter constructs to monitor the dynamics of infection as well as the efficacy of therapeutics for B. mallei in real-time. A stable luminescent reporter B. mallei strain was created using the pUTmini-Tn5::luxKm2 plasmid and used to monitor glanders in the BALB/c murine model. Mice were infected via the intranasal route with 5 × 103 bacteria and monitored by BLI at 24, 48, and 72 h. We verified that our reporter construct maintained similar virulence and growth kinetics compared to wild-type B. mallei and confirmed that it maintains luminescent stability in the presence or absence of antibiotic selection. The luminescent signal was initially seen in the lungs, and progressed to the liver and spleen over the course of infection. We demonstrated that antibiotic treatment 24 h post-infection resulted in reduction of bioluminescence that can be attributed to decreased bacterial burden in target organs. These findings suggest that BLI can be used to monitor disease progression and efficacy of therapeutics during glanders infections. Finally, we report an alternative method to mini-Tn5::luxKm2 transposon using mini-Tn7-lux elements that insert site-specifically at known genomic attachment sites and that can also be used to tag bacteria.
Wrinkles as the Result of Compressive Stresses in an Annular Thin Film

It is well‐known that an elastic sheet loaded in tension will wrinkle and that the length scale of the wrinkles tends to 0 with vanishing thickness of the sheet [Cerda and Mahadevan, Phys. Rev. Lett. 90, 074302 (2003)]. We give the first mathematically rigorous analysis of such a problem. Since our methods require an explicit understanding of the underlying (convex) relaxed problem, we focus on the wrinkling of an annular sheet loaded in the radial direction [Davidovitch et al., Proc. Natl. Acad. Sci. 108 (2011), 18227]. Our main achievement is identification of the scaling law of the minimum energy as the thickness of the sheet tends to 0. This requires proving an upper bound and a lower bound that scale the same way. We prove both bounds first in a simplified Kirchhoff‐Love setting and then in the nonlinear three‐dimensional setting. To obtain the optimal upper bound, we need to adjust a naive construction (one family of wrinkles superimposed on a planar deformation) by introducing a cascade of wrinkles. The lower bound is more subtle, since it must be ansatz‐free. © 2014 Wiley Periodicals, Inc.
Is childhood sexual victimization associated with cognitive distortions, self-esteem, and emotional congruence with children?

ABSTRACT The current paper examined the association between childhood sexual victimization (CSV) and constructs thought to be relevant for sexual offending in secondary analyses of three samples of adult males who committed sexual offences against children (N = 16, 28, and 20). Compared to participants who reported no CSV, those who reported CSV exhibited slightly to moderately more cognitive distortions and moderately to largely less negative evaluations of sexual offending against children; slightly to moderately higher self-esteem, positive evaluation of people who commit sexual offences, and identification with people who commit sexual offences against children; and much more emotional congruence with children. Our findings suggest that CSV may be associated with variables presumed to play a role in sexual offending against children. However, given the small sample sizes and other limitations of our studies, our evidence does not permit conclusions regarding causal relationships and any novel findings require replication.
Relationship Repertoires, the Price of Parenthood, and the Costs of Contraception

Drawing on 150 in-depth interviews with African American male and female youth who have spent much of their lives in neighborhoods of concentrated poverty, we explore the structural and cultural underpinnings of the elevated rate of unplanned childbearing among disadvantaged youth. We find that gender asymmetry in perceived opportunity costs, shared social meanings associated with condom use, and perceptions of health risk associated with hormonal and other female forms of birth control such as intrauterine devices—perceptions that may be rooted in a generalized distrust of the medical establishment—are promising explanations not usually considered in the literature on unintended fertility. These findings offer additional insight into how disadvantaged youth calculate the opportunity costs of childbearing and raise additional considerations for policies surrounding family planning and reproduction in the context of urban poverty.
Analysis of African Easterly Wave Structures and Their Role in Influencing Tropical Cyclogenesis

Abstract Composite structures of African easterly waves (AEWs) that develop into named tropical cyclones in the Atlantic are compared and contrasted with nondeveloping AEWs using the 40-yr ECMWF Re-Analysis (ERA-40) data and satellite brightness temperature between 1979 and 2001. Developing AEWs are characterized by a more distinctive cold-core structure two days before reaching the West African coast. As they move westward, the convective activity increases further in the vicinity of the Guinea Highlands region. At the same time the AEW trough increases its vorticity at low levels consistent with a transformation toward a more warm-core structure before it reaches the ocean. As the AEW moves over the ocean convection is maintained in the trough, consistent with the observed tropical cyclogenesis. The nondeveloping AEW has a similar evolution before reaching the coast except that the amplitudes are weaker and there is less convective activity in the Guinea Highlands region. The nondeveloping AEW composite.
Semantic and Associative Priming in a Distributed Attractor Network

A distributed attractor network is trained on an abstract version of the task of deriving the meanings of written words. When processing a word, the network starts from the final activity pattern of the previous word. Two words are semantically related if they overlap in their semantic features, whereas they are associatively related if one word follows the other frequently during training. After training, the network exhibits two empirical effects that have posed problems for distributed network theories: much stronger associative priming than semantic priming, and significantassociative priming across an intervening unrelated item. It also reproduces the empirical findingsof greater priming for low-frequency targets, degraded targets, and high-dominance category exemplars.
Evidence for a causal association between human papillomavirus and a subset of head and neck cancers.

BACKGROUND High-risk human papillomaviruses (HPVs) are etiologic agents for anogenital tract cancers and have been detected in head and neck squamous cell carcinomas (HNSCCs). We investigated, retrospectively, an etiologic role for HPVs in a large series of patients with HNSCC. METHODS Tumor tissues from 253 patients with newly diagnosed or recurrent HNSCC were tested for the presence of HPV genome by use of polymerase chain reaction (PCR)-based assays, Southern blot hybridization, and in situ hybridization. The viral E6 coding region was sequenced to confirm the presence of tumor-specific viral isolates. Exons 5-9 of the TP53 gene were sequenced from 166 specimens. The hazard of death from HNSCC in patients with and without HPV-positive tumors was determined by proportional hazards regression analysis. RESULTS HPV was detected in 62 (25%) of 253 cases (95% confidence interval [CI] = 19%-30%). High-risk, tumorigenic type HPV16 was identified in 90% of the HPV-positive tumors. HPV16 was localized specifically by in situ hybridization within the nuclei of cancer cells in preinvasive, invasive, and lymph node disease. Southern blot hybridization patterns were consistent with viral integration. Poor tumor grade (odds ratio [OR] = 2.4; 95% CI = 1.2- 4.9) and oropharyngeal site (OR = 6.2; 95% CI = 3.1-12.1) independently increased the probability of HPV presence. As compared with HPV-negative oropharyngeal cancers, HPV-positive oropharyngeal cancers were less likely to occur among moderate to heavy drinkers (OR = 0.17; 95% CI = 0.05-0.61) and smokers (OR = 0.16; 95% CI = 0.02-1.4), had a characteristic basaloid morphology (OR = 18.7; 95% CI = 2.1-167), were less likely to have TP53 mutations (OR = 0.06; 95% CI = 0.01-0. 36), and had improved disease-specific survival (hazard ratio [HR] = 0.26; 95% CI = 0.07-0.98). After adjustment for the presence of lymph node disease (HR = 2.3; 95% CI = 1.4- 3.8), heavy alcohol consumption (HR = 2.6; 95% CI = 1.4-4.7), and age greater than 60 years old (HR = 1.4; 95% CI = 0.8-2.3), all patients with HPV-positive tumors had a 59% reduction in risk of death from cancer when compared with HPV-negative HNSCC patients (HR = 0.41; 95% CI = 0.20-0.88). CONCLUSIONS These data extend recent molecular and epidemiologic studies and strongly suggest that HPV-positive oropharyngeal cancers comprise a distinct molecular, clinical, and pathologic disease entity that is likely causally associated with HPV infection and that has a markedly improved prognosis.
Sexually transmitted organisms in sexually abused children

OBJECTIVE To establish the prevalence of sexually transmitted organisms and other genital organisms in potentially sexually abused children. DESIGN Prospective study of children attending an inner London department of community paediatrics for evaluation of possible sexual abuse. SUBJECTS Children under 16 referred for evaluation of possible sexual abuse. OUTCOME MEASURES Prevalence of sexually transmitted organisms in relation to age, symptoms, and type of abuse. RESULTS Swabs were taken from 159 of 242 girls evaluated. The overall prevalence of sexually transmitted organisms was 3.7%: three girls were infected with gonorrhoea, four withTrichomonas vaginalis, and two with Chlamydia trachomatis. One girl had all three infections plus mycoplasmas. Mycoplasmas were identified in 22% of girls swabbed. Of 30 boys swabbed, none yielded a sexually transmitted organism. CONCLUSIONS There is a low prevalence of definitely sexually transmitted organisms in children who might have been abused. Other organisms possibly associated with sexual activity can be identified in this population. Screening for infection should be mandatory in presumed sexually abused girls with vaginal discharge and ideally should be undertaken in all children attending for evaluation of sexual abuse.
Effects of Soil Characteristics, Allelopathy and Frugivory on Establishment of the Invasive Plant Carpobrotus edulis and a Co-Occuring Native, Malcolmia littorea

Background The species Carpobrotus edulis, native to South Africa, is one of the major plant invaders of Mediterranean coastal ecosystems around the world. Invasion by C. edulis exerts a great impact on coastal habitats. The low number of native species in invaded communities points to the possible existence of mechanisms suppressing their germination. In this study we assessed whether soil factors, endozoochory, competition and allelopathic effects of the invader affect its own early establishment and that of the native species Malcolmia littorea. We used laboratory solutions representing different chemical composition and moisture of the soil, herbivore feeding assays to simulate seed scarification and rainwater solutions to account for the effect of differently aged C. edulis litter. Principal Findings We show that unlike that of the native species, germination and early growth of C. edulis was not constrained by low moisture. The establishment of C. edulis, in terms of germination and early growth, was increased by scarification of seeds following passage through the European rabbit intestines; the rabbits therefore may have potential implications for plant establishment. There was no competition between C. edulis and M. littorea. The litter of the invasive C. edulis, which remains on the soil surface for several years, releases allelopathic substances that suppress the native plant germination process and early root growth. Conclusions The invasive species exhibits features that likely make it a better colonizer of sand dunes than the co-occurring native species. Allelopathic effects, ability to establish in drier microsites and efficient scarification by rabbits are among the mechanisms allowing C. edulis to invade. The results help to explain the failure of removal projects that have been carried out in order to restore dunes invaded by C. edulis, and the long-lasting effects of C. edulis litter need to be taken into account in future restoration projects.
Parent Scaffolding of Young Children When Engaged with Mobile Technology

Shared parent–child experiences while engaged with an iPadTM were examined to determine if and then how parents interact with their children when using mobile digital devices. In total, 104 parent–child dyads participated in an observation session where parent–child interactions using the touchscreen tablet device were video recorded in order to observe first-hand the supports and exchanges between parent and child (age range 46.21–75.9 months). Results indicate that parents provide a great deal of support to their children while interacting with the touchscreen tablet device including verbal, emotional-verbal, physical and emotional-physical supports. The types of support offered did not differ as a function of parent gender or experience with mobile devices (users versus non-users). Overall, parents rated their own experience engaging with the touchscreen tablet and that of their child’s positively. Additional survey measures assessed parents’ perceptions of their child’s technology use and attitudes regarding optimal ages and conditions for introducing and using technology. Most parents indicated a preference for very early introduction to mobile technologies. Implications of these findings are discussed.
The selective estrogen receptor modulator trioxifene (LY133314) inhibits metastasis and extends survival in the PAIII rat prostatic carcinoma model.

Trioxifene (LY133314) is a selective estrogen receptor modulator (SERM) with competitive binding activity against estradiol for estrogen receptor alpha (ERalpha) and antagonistic activity against ERalpha-mediated gene expression. The PAIII rat prostatic adenocarcinoma (PCa) is an androgen receptor-negative, ERalpha- and ERbeta-positive, spontaneously metastatic rodent tumor cell line. After s.c. implantation of 10(6) PAIII cells in the tail, s.c. administration of trioxifene (2.0, 4.0, 20.0, or 40.0 mg/kg-day) for 30 days produced significant (P < 0.05) inhibition of PAIII metastasis from the primary tumor in the tail to the gluteal and iliac lymph nodes (maximum nodal weight decreases, 86% and 88% from control values, respectively). PAIII metastasis to the lungs was significantly inhibited by trioxifene treatment. Numbers of pulmonary foci in PAIII-bearing rats were significantly (P < 0.05) reduced by trioxifene administration in a dose-related manner (maximal reduction, 98% from control values). Continual administration of the compound significantly (P < 0.05) extended survival of PAIII-bearing rats. Trioxifene inhibited the proliferation of PAIII cells at micromolar levels in vitro but did not slow growth of the primary tumor growth in the tail. Trioxifene administration also produced regression of male accessory sex organs. In PAIII-tumor-bearing animals, trioxifene administration produced a maximal regression of 76% for ventral prostate and 64% for seminal vesicle (P < 0.05 for both). SERMs may be preferable to estrogens given their efficacy in experimental PCa models and relative lack of side effects observed in clinical trials. Our data support the contention that trioxifene represents a SERM with potential antimetastatic efficacy for the treatment of androgen-independent, metastatic PCa.
Obsessive Compulsive Disorder, Anxiety and Depression

53 subjects who were diagnosed on ICD-9 as Obsessive Compulsive neurosis were studied. They were compared w i t h a randomly selected group of 53 subjects each of Anxiety neurosis and Manic Depressive Psychosis, currently depressed. Comparisons were made on socio-demong-raphic, family and illness rela:ed variables. The findings are discussed i n the l ight o f the recent l i terature on the nosological status of obsessive compulsive neurosis.
Adaptive robust output feedback control of a magnetic levitation system by k-filter approach

This work proposes an adaptive robust output feedback controller for position-tracking problem of a magnetic levitation system with a current feedback power amplifier. The controller is designed by a backstepping procedure with robustifying modification of the k-filter approach. The boundedness and guaranteed transient performance of the error signals are achieved by the nonlinear damping terms. And the ultimate position-tracking error is reduced by the adaptive laws. Experimental results are included to show the excellent control performance of the designed controller.
Reducing distress in university students: A randomised control trial of two online interventions

Objective University students experience high rates of distress and place increasing demands on provisions of support. Web‐based interventions may provide a low‐cost, accessible low intensity format to support students to make changes to improve their health and wellbeing. Method This study evaluated the efficacy of two web‐based interventions in the lead‐up to final exams: one on general mental health (thedesk) and one specifically focused on coping with distress (Care · Collaborate · Connect: Student Success). Because most students believe that stress is a normal part of the student experience (which might inhibit the effectiveness of support that is provided), we hypothesised that a program emphasising coping with stress would be more effective than a general program. Participants were 70 students with self‐reported elevated levels of psychological distress who were randomly assigned to one of the two programs. Results Contrary to predictions, both groups had significant reductions in distress (Cohen's ds = 0.54 and 0.67, respectively). Participants in the coping intervention reported making significantly more changes and using specific coping strategies at follow‐up. Conclusion These results suggest that web‐based interventions are effective in supporting students and improving emotional regulation.
Sibling Achievement, Sibling Gender, and Beliefs about Parental Investment: Evidence from a National Survey Experiment

Abstract:When siblings have different characteristics—such as different achievement or different gender—how should parents invest in their education? Although many studies have examined issues of parental investment using behavioral data, this research is often hindered by methodological constraints, including endogeneity and an inability to isolate the effects of predictor variables. This article takes an alternative approach by using data from an original, nationally representative survey experiment (N = 3,239). I assess how Americans believe parents should divide educational resources between siblings with different achievement and gender. In doing so, this article is the first to examine normative beliefs surrounding relative achievement, gender, and parental investment in siblings' education. When achievement is the only difference between siblings, respondents believe that lower achievers should receive more hands-on instructional resources and parental school involvement, and higher achievers should receive more resources that enhance cultural capital and support college enrollment. This pattern maps onto the way respondents divide resources between boys and girls. When gender is the only difference between siblings, respondents believe that boys should receive more instructional resources and parental school involvement, while girls should receive more cultural and college resources. When achievement and gender both differ, however, the effect of relative achievement typically crowds out the effect of gender, suggesting that respondents' evaluations of achievement are more persistent than their evaluations of gender. Implications for research on parental involvement in education are discussed.
Oncotargets and Therapy Dovepress Dovepress Diagnostic Value of Two-dimensional Shear Wave Elastography in Papillary Thyroid Microcarcinoma

hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms Objective: The purpose of this study was to evaluate the predictability of two-dimensional shear wave elastography (2D-SWE) for papillary thyroid microcarcinoma (PTMC). Materials and methods: One hundred and eighteen patients with 137 thyroid nodules (46 benign nodules, 91 malignant nodules) were included in this study who received conventional ultrasound (US) and 2D-SWE before fine-needle aspiration or surgery. The diagnostic performance was compared between US findings only and the combined use of US findings with 2D-SWE, which were correlated with pathology results. Results: Receiver-operating characteristic curve analysis was performed to assess the diagnostic performance of 2D-SWE. Conventional US findings and 2D-SWE values were analyzed and compared between benign and malignant thyroid nodules. Taller than wide, micro-calcification, and SWE_mean were found to be independent risk factors for predicting PTMC. The overall sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of combined conventional US features with 2D-SWE parameters were 95. Conclusion: The study indicates that the quantitative parameters of 2D-SWE are an independent predictive factor for diagnosing PTMC, which could provide valuable information when conventional US cannot give determinate results.