Miracle-dz/UniFAR-FTUs huggingface dataset:
A Comparative Survey of Aotearoa New Zealand and UK Social Workers on the Role of Religion and Spirituality in Practice

Increasingly, social work is being challenged to consider the role of spirituality and religion in practice and education as the profession has witnessed an expanding interest in the integration of spirituality, motivated by the recognition of spiritual diversity as an important component of human experience, cultural competency and anti-racist social work practice. In response to the lack of international empirical research in general, and relating to spirituality in particular, cross-national survey research was conducted in Aotearoa New Zealand (ANZ) and the UK as part of a larger multi-national study of social workers' attitudes about the role of spirituality in their practice. Although the two countries share some cultural similarities due to the impact of secularization, British settlement and colonization in ANZ, there are also significant differences related to the unique multicultural make-up of ANZ, emphasizing the indigenous Maori and the centrality of spirituality within a Maori worldview.
Critical role of the NKG2D receptor for NK cell‐mediated control and immune escape of B‐cell lymphoma

Little is known on the control of lymphomas by NK cells. Here, we study the role of the NK group 2D (NKG2D) receptor for the immunosurveillance of lymphoma. By using transplantable tumors as well as a λ‐myc‐transgenic model of endogenously arising lymphoma and NKG2D‐deficient mice, we show that NK cells eliminate tumor cells in vivo after receiving two signals. One step involved the activation of NK cells giving rise to IFN‐γ expression, which was effected by MHCIlow tumor cells or DCs. However, this was necessary but not sufficient to mediate cytotoxicity. Triggering cytotoxicity additionally required a second step, which could be mediated by engagement of the NKG2D receptor. Thus, NKG2D‐deficient NK cells could become activated in vivo, but they were not able to reject transplanted lymphomas or to degranulate in animals bearing autochthonous lymphomas. Tumor growth in NKG2D‐deficient λ‐myc‐transgenic mice was significantly accelerated compared to NKG2D‐competent animals. Whereas the latter developed tumors that lost expression of NKG2D ligands (NKG2D‐L) in late disease stages, this did not occur in NKG2D‐deficient mice. This indicates that NK cells and the NKG2D receptor play a role for control of lymphomas and that selection for NKG2D‐L loss mutants provides a mechanism of tumor escape.
Love and work: career-family attitudes of new entrants into the labor force

This paper reports the development of the Career–Family Attitudes Measure (CFAM), a new 56-item instrument for measuring individuals' attitudes towards managing the career and family interface. The measure was administered to a large sample of high school students and factor analyzed to reveal six dimensions of career and family attitudes, which were then scaled. Females in the sample had significantly more positive attitudes towards Balance and Independence than did males, while males had significantly more positive attitudes towards Dominance and Spousal Support than did females. Antecedents such as parental employment history and educational aspirations were significantly related to several of the scales. Results indicated that career–family attitudes involve preferences for the integration of career and family rather than for trade-offs between them. Research to establish the validity and explore the many applications of the CFAM is needed. © 1998 John Wiley & Sons, Ltd.
Regulation of ATP13A2 via PHD2-HIF1α Signaling Is Critical for Cellular Iron Homeostasis: Implications for Parkinson's Disease

We previously reported that pharmacological inhibition of a class of enzymes known as prolyl hydroxylase domain proteins (PHDs) has neuroprotective effects in various in vitro and in vivo models of Parkinson's disease (PD). We hypothesized that this was due to inhibition of the PHD2 isoform, preventing it from hydroxylating the transcription factor hypoxia inducible factor 1 α (HIF1α), targeting it for eventual proteasomal degradation. HIF1α itself induces the transcription of various cellular stress genes, including several involved in iron metabolism. Although all three isoforms of PHD are expressed within vulnerable dopaminergic (DAergic) substantia nigra pars compacta neurons, only select downregulation of the PHD2 isoform was found to protect against in vivo neurodegenerative effects associated with the mitochondrial neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. These findings were corroborated in induced pluripotent stem cell-derived neurons, providing validation in a pertinent human cell model. PHD2 inhibition was found to result in increased expression of ATP13A2, mutation of which is responsible for a rare juvenile form of PD known as Kufor-Rakeb syndrome. Knockdown of ATP13A2 expression within human DAergic cells was found to abrogate restoration of cellular iron homeostasis and neuronal cell viability elicited by inhibition of PHD2 under conditions of mitochondrial stress, likely via effects on lysosomal iron storage. These data suggest that regulation of ATP13A2 by the PHD2-HIF1α signaling pathway affects cellular iron homeostasis and DAergic neuronal survival. This constitutes a heretofore unrecognized process associated with loss of ATP13A2 function that could have wide-ranging implications for it as a therapeutic target for PD and other related conditions. SIGNIFICANCE STATEMENT Reductions in PHD2 activity within dopaminergic neurons in vivo and in cultured human induced pluripotent stem cell-derived neurons protects against mitochondrial stress-induced neurotoxicity. Protective effects are dependent on downstream HIF-1α expression. Knockdown of ATP13A2, a gene linked to a rare juvenile form of Parkinson's disease and recently identified as a novel HIF1α target, was found to abrogate maintenance of cellular iron homeostasis and neuronal viability elicited by PHD2 inhibition in vivo and in cultured dopaminergic cells under conditions of mitochondrial stress. Mechanistically, this was due to ATP13A2's role in maintaining lysosomal iron stores. This constitutes a novel mechanism by which alterations in ATP13A2 activity may be driving PD-related neuropathology.
Ethanolic leaf extract of neem (Azadirachta indica) inhibits buccal pouch carcinogenesis in hamsters

We evaluated the chemopreventive effects of ethanolic neem leaf extract in the initiation and post‐initiation phases of 7,12‐dimethylbenz[a]anthracene (DMBA)‐induced hamster buccal pouch (HBP) carcinogenesis. The frequency of bone marrow micronuclei as well as the concentrations of lipid peroxides, ratio of reduced to oxidized glutathione (GSH/GSSG), and the activities of the GSH‐dependent enzymes glutathione peroxidase (GPx) and glutathione‐S‐transferase (GST) in the buccal pouch, liver and erythrocytes were used as biomarkers of chemoprevention. All the hamsters painted with DMBA alone for 14 weeks developed buccal pouch carcinomas that showed diminished lipid peroxidation and enhanced antioxidant status associated with increased frequencies of bone marrow micronuclei. In the liver and erythrocytes of tumour‐bearing animals, enhanced lipid peroxidation was accompanied by compromised antioxidant defences. Administration of ethanolic neem leaf extract effectively suppressed DMBA‐induced HBP carcinogenesis as revealed by the absence of tumours in the initiation phase and reduced tumour incidence in the post‐initiation phase. In addition, ethanolic neem leaf extract modulated lipid peroxidation and enhanced antioxidant status in the pouch, liver and erythrocytes and reduced the incidence of bone marrow micronuclei. The results of the present study, demonstrate that ethanolic neem leaf extract inhibits the development of DMBA‐induced HBP tumours by protecting against oxidative stress. Copyright © 2004 John Wiley & Sons, Ltd.
School-Based Behavioral Consultation: Delivering Treatment for Children's Externalizing Behavior in the Classroom

This study examined the efficacy of school-based behavioral consultation as a method of delivering treatment for children with externalizing behavior problems. Behavioral consultation was conducted with teachers of 3 general education students identified as exhibiting clinically significant externalizing behavior in the classroom. An A-B design with replication across participants and a follow-up phase was used to analyze the effectiveness of consultative treatment on students' disruptive behavior. Direct observation and behavioral checklist data indicated a significant decrease in externalizing behavior from baseline to treatment. Teachers indicated satisfaction with consultation services and viewed the treatment plan as appropriate, fair, and reasonable for their students. The results are taken as general support for the effectiveness of school-based behavioral consultation as a method of delivering treatment for children with significant behavior problems. Limitations, implications for consultation pra.
Phenomenology and curriculum implementation: discerning a living curriculum through the analysis of Ted Aoki’s situational praxis

The argumentation in this paper is grounded in a critical and conceptual analysis of Ted Aoki’s phenomenology, wherein curriculum is read as phenomenological text. The problem explored emerges from Aoki’s critique of the Tyler rationale for curriculum design, implementation and evaluation as it is conceived and practised in contemporary standardized education, which is driven by the ideology of social efficiency. Aoki focuses on the way in which the scientific and technical modes of curriculum implementation preclude particular modes of Being-in-the-world because curriculum implementation, as a technical and instrumental process, reduces both educators and students to epistemological subjects, and beyond, objects of knowledge. By focusing on curriculum implementation as a form of ‘situational-praxis’ as opposed to ‘instrumental-action’, this paper concludes, it is possible to put educators and students in touch with the ontological aspects of their Being-in-the-world. Aoki’s practice of phenomenology reveals an understanding of an attuned mode of human transcendence in learning, which opens the possibility for an authentic educational experience where educators and students dwell in the midst of the curriculum’s unfolding as an ontological phenomenon.
Temporal processing deficits in letter-by-letter reading by Ingles and Eskes

Based on his seminal contributions in 1891 and 1892, Dejerine is widely credited for initiating the investigation of acquired dyslexia. In the first contribution (1891) he described a patient who developed an inability to read and write after suffering an infarction of the left hemisphere. Dejerine designated the disorder “Alexia with Agraphia”; he attributed it to a loss of the “optical images” of words that were presumed to be supported by the angular gyrus. In 1892, Dejerine described a patient who was able to write but could not read what he (and others) had written (Dejerine, 1892). This disorder, variously known as Alexia without Agraphia, Pure Alexia or Agnosic Alexia, has been reported with regularity since the original account. Although subsequent reports have noted aspects of the disorder not emphasized in Dejerine's index case—pure alexia may be associated with surface (Patterson & Kay, 1982) or deep (Buxbaum & Coslett, 1996) dyslexia—the essential features of the disorder were well documented by Dejerine and the syndrome remains quite consistent with respect to its core phenomenology. Similarly, the pathologic substrate of the disorder has proven to be remarkably constant: the vast majority of patients with pure alexia have lesions involving the occipital lobe of the dominant hemisphere and either the forceps major or, less commonly, the splenium of the corpus callosum. The latter component of the lesion interrupts the white matter tracts connecting the visual association cortices of the right and left hemispheres.
Temporal stereo disparity estimation with graph cuts

In this paper, we propose a temporal stereo disparity estimation method. Conventional stereo disparity estimation methods rely on matching costs regarding computation of intensity or position similarities. However, most applications do not consider the temporal dimension when estimating the disparity. In other words, previous approaches disregard potentially useful disparity information that is already estimated. Therefore, we exploit reasonable temporal disparity information for accurate disparity map estimation. First, we calculate the optical flow between two color frames. Then, the disparity from the previous frame becomes reliable information, shrinking the value of candidate disparity. Consequently, the proposed technique increases the temporal consistency of estimated disparity maps and outperforms per-frame methods when image noise is present.
Switch of Voltage-Gated K+ Channel Expression in the Plasma Membrane of Chondrogenic Cells Affects Cytosolic Ca2+-Oscillations and Cartilage Formation

Background Understanding the key elements of signaling of chondroprogenitor cells at the earliest steps of differentiation may substantially improve our opportunities for the application of mesenchymal stem cells in cartilage tissue engineering, which is a promising approach of regenerative therapy of joint diseases. Ion channels, membrane potential and Ca2+-signaling are important regulators of cell proliferation and differentiation. Our aim was to identify such plasma membrane ion channels involved in signaling during chondrogenesis, which may serve as specific molecular targets for influencing chondrogenic differentiation and ultimately cartilage formation. Methodology/Principal Findings Using patch-clamp, RT-PCR and Western-blot experiments, we found that chondrogenic cells in primary micromass cell cultures obtained from embryonic chicken limb buds expressed voltage-gated NaV1.4, KV1.1, KV1.3 and KV4.1 channels, although KV1.3 was not detectable in the plasma membrane. Tetrodotoxin (TTX), the inhibitor of NaV1.4 channels, had no effect on cartilage formation. In contrast, presence of 20 mM of the K+ channel blocker tetraethyl-ammonium (TEA) during the time-window of the final commitment of chondrogenic cells reduced KV currents (to 27±3% of control), cell proliferation (thymidine incorporation: to 39±4.4% of control), expression of cartilage-specific genes and consequently, cartilage formation (metachromasia: to 18.0±6.4% of control) and also depolarized the membrane potential (by 9.3±2.1 mV). High-frequency Ca2+-oscillations were also suppressed by 10 mM TEA (confocal microscopy: frequency to 8.5±2.6% of the control). Peak expression of TEA-sensitive KV1.1 in the plasma membrane overlapped with this period. Application of TEA to differentiated chondrocytes, mainly expressing the TEA-insensitive KV4.1 did not affect cartilage formation. Conclusions/Significance These data demonstrate that the differentiation and proliferation of chondrogenic cells depend on rapid Ca2+-oscillations, which are modulated by KV-driven membrane potential changes. KV1.1 function seems especially critical during the final commitment period. We show the critical role of voltage-gated cation channels in the differentiation of non-excitable cells with potential therapeutic use.
Mediators of Physical Activity on Neurocognitive Function: A Review at Multiple Levels of Analysis

Physical activity (PA) is known to maintain and improve neurocognitive health. However, there is still a poor understanding of the mechanisms by which PA exerts its effects on the brain and cognition in humans. Many of the most widely discussed mechanisms of PA are molecular and cellular and arise from animal models. While information about basic cellular and molecular mechanisms is an important foundation from which to build our understanding of how PA promotes cognitive health in humans, there are other pathways that could play a role in this relationship. For example, PA-induced changes to cellular and molecular pathways likely initiate changes to macroscopic properties of the brain and/or to behavior that in turn influence cognition. The present review uses a more macroscopic lens to identify potential brain and behavioral/socioemotional mediators of the association between PA and cognitive function. We first summarize what is known regarding cellular and molecular mechanisms, and then devote the remainder of the review to discussing evidence for brain systems and behavioral/socioemotional pathways by which PA influences cognition. It is our hope that discussing mechanisms at multiple levels of analysis will stimulate the field to examine both brain and behavioral mediators. Doing so is important, as it could lead to a more complete characterization of the processes by which PA influences neurocognitive function, as well as a greater variety of targets for modifying neurocognitive function in clinical contexts.
Economic Segregation, Race, and Homicide

Prior research assessing the association between structured inequality and homicides has produced inconsistent findings, particularly in regard to establishing an association between economic disadvantage and black homicide rates. In this study, we employ a measure of the spatial distribution of income, Jargowksy's (1996) economic segregation measure, to assess overall and race-specific homicide rates. Copyright (c) 2006 Southwestern Social Science Association.
Predicting Bugs Using Antipatterns

Bug prediction models are often used to help allocate software quality assurance efforts. Software metrics (e.g., process metrics and product metrics) are at the heart of bug prediction models. However, some of these metrics like churn are not actionable, on the contrary, antipatterns which refer to specific design and implementation styles can tell the developers whether a design choice is "poor" or not. Poor designs can be fixed by refactoring. Therefore in this paper, we explore the use of antipatterns for bug prediction, and strive to improve the accuracy of bug prediction models by proposing various metrics based on antipatterns. An additional feature to our proposed metrics is that they take into account the history of antipatterns in files from their inception into the system. Through a case study on multiple versions of Eclipse and ArgoUML, we observe that (i) files participating in antipatterns have higher bug density than other files, (ii) our proposed antipattern based metrics can provide additional explanatory power over traditional metrics, and (iii) improve the F-measure of cross-system bug prediction models by 12.5% in average. Managers and quality assurance personnel can use our proposed metrics to better improve their bug prediction models and better focus testing activities and the allocation of support resources.
Should Children Who Wear a Cochlear Implant in One Ear Use a Hearing Aid in the Opposite Ear ?

People who can hear with both ears understand speech better in noisy environments and locate where sounds come from better than those who hear with only one ear. Hearing-impaired children are, therefore, generally fitted with two hearing aids so that they could benefit from hearing binaurally. Children who use a cochlear implant in one ear and no amplification in the opposite ear are, however, deprived of these advantages. If the non-implanted ear were left unaided for too long, its ability to process speech would decrease (Gelfand and Silman 1993; Gatehouse 1992). Although the residual hearing in the ear is often useable for acoustic amplification, there has been little consideration of fitting a hearing aid to the non-implanted ear. Clinicians and professionals who work with children had uncertainties about how to fit, and whether it is beneficial to do so. Does a hearing aid need to be adjusted differently depending on whether a cochlear implant or a hearing aid is worn in the other ear? Does the use of a hearing aid interfere with the use of a cochlear implant? Can a child integrate information from an acoustic input and an electrical input to obtain binaural benefits? Would these benefits, if any, be affected by the implant processing strategy? Does a period of discontinued hearing aid use after implantation prevent a child from deriving hearing aid benefit? In this paper, we will address these questions by reviewing some recent work at the National Acoustic Laboratories in Australia.
Comparison of the Transarterial Axillary Block and the Ultrasound-Guided Infraclavicular Block for Upper Extremity Surgery: A Prospective Randomized Trial

Background and Objectives: The transarterial axillary block and the ultrasound-guided infraclavicular block are both effective methods of anesthetizing the upper extremity. This study compares these methods with respect to subjective postoperative dysesthesias, block adequacy, patient comfort, and patient satisfaction. Methods: Two hundred thirty-two patients were randomized to receive an ultrasound-guided infraclavicular block or a transarterial axillary block for upper extremity surgery. Block placement, motor and sensory testing, and block adequacy data were recorded. The subjects were contacted by a blinded research assistant at 2 and 10 days postoperatively to assess for the presence of dysesthesias and pain and to assess patient satisfaction. Results: The 2 techniques were similar with respect to block performance time and adequacy of the block for surgery. There was no significant difference between the blocks in terms of postoperative dysesthesias (23.9% in the axillary group vs 17.1% in the infraclavicular group at 2 days, P = 0.216, and 11.0% vs 6.31% at 10 days, P = 0.214). None of the dysesthesias were permanent. The infraclavicular block had a lower incidence of paresthesias during placement (P = 0.035) and was associated with less pain at the block site (P = 0.010 at 2 days, P = 0.002 at 10 days). More patients were willing to undergo the infraclavicular block as a future anesthetic when compared with the axillary block (P = 0.025 at 10 days). Conclusions: There is no significant difference between the 2 techniques in terms of adequacy for surgery and subjective postoperative dysesthesias. The ultrasound-guided infraclavicular block is associated with greater patient comfort and willingness to undergo the same anesthetic when compared with the transarterial axillary block.
Improving Empirical Models with Machine Learning

Inaccuracies of sediment transport models largely originate from the difficulties to describe the process in precise mathematical terms. Machine learning (ML) is an alternative approach to reduce the inaccuracies of sedimentation models. It utilizes available domain knowledge for selecting the input and output variables for the ML models and uses non-linear regression techniques to fit the measured data. Two ML methods, artificial neural networks (ANN) and model trees, are adopted to model bed-load and total-load transport using the measured data. Special effort was made to ensure that the empirical formulations known from the sedimentation research would be taken into account. ML models were found to be more accurate than the existing ones.