Miracle-dz/UniFAR-FTUs huggingface dataset:
Statistical group comparison of diffusion tensors via multivariate hypothesis testing

Diffusion tensor imaging (DTI) provides a powerful tool for identifying white matter (WM) alterations in clinical populations. The prevalent method for group‐level analysis of DTI is statistical comparison of the diffusion tensor fractional anisotropy (FA) metric. The FA metric, however, does not capture the full orientational information contained in the diffusion tensor. For example, the FA test is incapable of detecting group‐level differences in diffusion orientation when the level of anisotropy is unaffected. Here, we apply multivariate hypothesis testing procedures to the elements of the diffusion tensor as an alternative to univariate testing using FA. Both parametric and nonparametric tests are proposed with each choice carrying specific assumptions about the diffusion tensor model. Of particular interest is the Cramér test, which works on Euclidean interpoint distances and can be readily adapted to a specific non‐Euclidean framework by applying matrix logarithms to the diffusion tensors. Using Monte Carlo simulations, we show that multivariate tests can detect diffusion tensor principal eigenvector differences of 15 degrees with up to 80–90% power under typical design conditions. We also show that some multivariate tests are more sensitive to FA differences, when compared to a univariate test on FA, even if there is no principal eigenvector difference. The Cramér test, using the Euclidean interpoint distances, performed best under both simulation scenarios. When applying the Cramér test of the diffusion tensor in a clinical population with a history of migraine, a 169% increase was observed in the volume of a significant cluster compared to the univariate FA test. Magn Reson Med 57:1065–1074, 2007. © 2007 Wiley‐Liss, Inc.
Positive Group Affect and Team Creativity

The study explores group-level mechanisms linking positive group affective tone (PGAT) and team creativity. Drawing on Paulus and Dzindolet’s group creativity model and the broaden-and-build theory of positive emotions, the mediating roles of team reflexivity and team promotion focus were examined. Survey data were collected from the leaders and members of 98 work teams in South Korea. Structural equation modeling results showed that when controlling for negative group affective tone, PGAT was significantly associated with team creativity. Furthermore, team reflexivity and team promotion focus fully mediated the relationship between PGAT and team creativity, and this effect held when team prevention focus was controlled for. The findings provide meaningful insights into the roles of team reflexivity and team promotion focus as critical social-cognitive and social-motivational processes in the group affect–creativity relationship.
The Distribution of Survey Contact and Participation in the United States: Constructing a Survey-Based Estimate

In this article, the authors show how survey responses to the question “How often have you participated in a survey in the past [specified time period]? ” can be used to construct a meaningful estimate of average survey contact and response rates in the population at large, as well as of the distribution of survey responses in the population. That is, the authors show how the nonresponse bias associated with asking people about their prior survey participation can be removed. They propose and validate a simple yet powerful statistical model of survey contact across the U.S. population and of survey response among those contacted. The authors find that survey contact and participation rates are lower than previously assumed and that a small percentage of the population is completing the majority of surveys.
Effects of Resveratrol in Pregnancy Using Murine Models with Reduced Blood Supply to the Uterus

Preeclampsia (PE) and fetal growth restriction (FGR) contribute significantly to fetal and maternal morbidity and mortality. Although the causes of PE and FGR are not fully understood, both conditions are known to be associated with impaired uterine artery blood flow. Resveratrol, a polyphenol found in a number of plants, has been shown to induce relaxation of uterine arteries in vitro as well as improve many pathological conditions associated with PE and FGR. We hypothesized that treatment of endothelial nitric oxide synthase knockout mice (eNOS−/−) and catechol-O-methyltransferase knockout mice (COMT−/−) with resveratrol during pregnancy would improve uterine artery blood flow and therefore ameliorate the PE-like phenotype and FGR in these murine models. Pregnant C57BL/6J, eNOS−/− and COMT−/− mice received either resveratrol supplemented diet (4 g/kg diet) or control diet between gestational day (GD) 0.5 and GD 18.5. Resveratrol supplementation significantly increased uterine artery blood flow velocity and fetal weight in COMT−/− but not in eNOS−/− mice. There were no effects of resveratrol on litter size and placental weight among the groups. In conclusion, resveratrol increased uterine artery blood flow velocity and fetal weight in COMT−/− mice, suggesting potential as a therapeutic strategy for PE and FGR.
Expression and functional characterization of FOXP3+CD4+ regulatory T cells in ulcerative colitis

Background CD4+CD25+ regulatory T cells (TR) can prevent or treat experimental murine colitis but little is known about their potential role in human inflammatory bowel disease (IBD). FOXP3 is a transcription factor that plays a critical role in the development and function of CD4+CD25+ TR. The aim of this study was to examine the presence and functional characteristics of TR cells in colonic lymphoid tissues in patients with ulcerative colitis (UC). Methods FOXP3 expression was assessed by flow cytometry, immunohistochemistry, and reverse‐transcriptase polymerase chain reaction (RT‐PCR). Functional characterization of CD4+CD25+ cells was analyzed by suppression of proliferation and secretion of cytokines by cocultured effector CD4+CD25− T cells. Results FOXP3+CD4+ T cells are increased in the lamina propria (LP) of inflamed and noninflamed areas of UC colon compared to normal colon. CD4+CD25+ T cells in UC mesenteric lymph nodes (MLN) express FOXP3 mRNA and protein and suppress the proliferation of autologous MLN CD4+CD25− T cells. The suppressor activity of MLN CD4+CD25+ T cells is cell contact‐dependent but cytokine‐independent. In addition, CD4+CD25+ T cells potently suppress the production of both Th1 (IFN‐&ggr;, IL‐2) and Th2 (IL‐5, IL‐13) cytokines by cocultured CD4+CD25− T cells. FOXP3+ cells localized in the T‐cell‐rich areas of MLN and occasionally present in the follicles. Conclusions There is an expansion of FOXP3+CD4+ T cells in mucosal lymphoid tissues in UC. CD4+CD25+ isolated from UC MLN express FOXP3 and display features of TR cells in spite of active mucosal inflammation. These data suggest that their suppressor activity may be abrogated in vivo or they are unable to counterbalance the chronic mucosal inflammation in UC. (Inflamm Bowel Dis 2007)
Flying the nest: how the home department shapes researchers’ career paths

This paper studies the importance of the socialization environment – nest – for the career destinations of early career researchers. In a sample of research groups in the fields of science and engineering at universities in Germany, we identify research orientation, output, funding as well as openness to industry and commercialization as relevant components. Nests that attract more public funding and are led by professors with high research performance are more likely to produce researchers who take jobs in public research, while links to industry predict jobs in the private sector. In a more nuanced analysis that differentiates between types of industry employment, we find that larger firms also recruit from groups with higher scientific performance, while small and medium-sized firms recruit from nests with a higher patent productivity. A focus on experimental development instead is associated with academic start-ups, and an applied focus with employment in consulting. Recommendations for research training are discussed.
Syntactic analyses and named entity recognition for PubMed and PubMed Central — up-to-the-minute

Although advanced text mining methods specifically adapted to the biomedical domain are continuously being developed, their applications on large scale have been scarce. One of the main reasons for this is the lack of computational resources and workforce required for processing large text corpora. In this paper we present a publicly available resource distributing preprocessed biomedical literature including sentence splitting, tokenization, part-of-speech tagging, syntactic parses and named entity recognition. The aim of this work is to support the future development of largescale text mining resources by eliminating the time consuming but necessary preprocessing steps. This resource covers the whole of PubMed and PubMed Central Open Access section, currently containing 26M abstracts and 1.4M full articles, constituting over 388M analyzed sentences. The resource is based on a fully automated pipeline, guaranteeing that the distributed data is always up-to-date. The resource is available at https://turkunlp. github.io/pubmed_parses/.
Preservice Physical Educators' Stress and Instructional Effectiveness

Preservice Physical Educators’ Stress and Instructional Effectiveness Jingyang Huang The primary purpose of this study was to determine the relationship between preservice physical educators’ stress and their instructional effectiveness. The study sample included 25 preservice physical educators in the Middle School Block and Secondary School Block in a Physical Education Teacher Education program located in the mid-Atlantic area of the United States. A demographic questionnaire, the Teacher Stress Scale, the West Virginia University Teaching Evaluation System, and interview questions were administered during preservice physical educators’ practice teaching period. The results indicated that preservice physical educators’ stress was negatively correlated with instructional effectiveness. Curriculum model and noise were reported as new factors that affected preservice physical educators’ stress and instructional effectiveness. In addition, the relationships between other demographic variables (e.g., block levels, gender, familiarity with a specific sport, confidence, readiness, and self-efficacy) and preservice physical educators’ stress were unveiled. Implications for PETE programs were also provided.
HLA Transgenic Mice Provide Evidence for a Direct and Dominant Role of HLA Class II Variation in Modulating the Severity of Streptococcal Sepsis1

Our epidemiologic studies on invasive Group A Streptococci (GAS) infections identified specific HLA class II haplotypes/alleles conferring high-risk or protection from streptococcal toxic shock syndrome with a strong protection conferred by the DRB1*15/DQB1*06 haplotype. We used HLA-transgenic mice to provide an in vitro and in vivo validation for the direct role of HLA class II allelic variation in streptococcal toxic shock syndrome. When splenocytes from mice expressing the protective HLA-DQB1*06 (DQ6) allele were stimulated with a mixture of streptococcal superantigens (SAgs), secreted by the prevalent M1T1 strain, both proliferative and cytokine responses were significantly lower than those of splenocytes from mice expressing the neutral DRB1*0402/DQB1*0302 (DR4/DQ8) alleles (p < 0.001). In crisscross experiments, the presentation of SAgs to pure T cells from either the DQ6 or the DR4/DQ8 mice resulted in significantly different levels of response depending on the HLA type expressed on the APCs. Presentation by HLA-DQ6 APCs elicited significantly lower responses than the presentation by HLA-DR4/DQ8 APCs. Our in vitro data were supported by in vivo findings, as the DQ6 mice showed significantly longer survival post-i.v. infection with live M1T1 GAS (p < 0.001) and lower inflammatory cytokine responses as compared with the DR4/DQ8 mice (p < 0.01). The data presented here provide evidence for a direct role of HLA class II molecules in modulating responses to GAS SAgs and underscore the dominant role of HLA class II allelic variation in potentiating the severity of GAS systemic infections.
INTRAHEPATIC EXPRESSION OF SERUM HEPATITIS VIRUS-ASSOCIATED ANTIGENS

SH virus-associated antigens have been identified in the liver and blood by immunofluorescence. This antigenic expression of the hepatitis agent or its genome is found in the cytoplasm of hepatocytes and other cells of the liver. Acute hepatitis is associated with hepatocellular localization of SH antigen, whereas alternative or additional SH antigen in the cytoplasm of nonhepatocytes is observed in chronic or recurrent hepatitis. Persistent intrahepatic SH antigen has also been observed in conversion from acute to chronic hepatitis, and the persistence of this virus-associated antigen in the liver may serve a significant pathogenetic role in mediating direct anti-tissue responses as well as local immune complex reactions. Competitive inhibition studies of SH antigen suggest at least two antigenically and sterically independent determinants on the SH particle.
A Specialized Forebrain Circuit for Vocal Babbling in the Juvenile Songbird

Young animals engage in variable exploratory behaviors essential for the development of neural circuitry and adult motor control, yet the neural basis of these behaviors is largely unknown. Juvenile songbirds produce subsong—a succession of primitive vocalizations akin to human babbling. We found that subsong production in zebra finches does not require HVC (high vocal center), a key premotor area for singing in adult birds, but does require LMAN (lateral magnocellular nucleus of the nidopallium), a forebrain nucleus involved in learning but not in adult singing. During babbling, neurons in LMAN exhibited premotor correlations to vocal output on a fast time scale. Thus, juvenile singing is driven by a circuit distinct from that which produces the adult behavior—a separation possibly general to other developing motor systems.
Activation of Mu Opioid Receptors Sensitizes Transient Receptor Potential Vanilloid Type 1 (TRPV1) via β-Arrestin-2-Mediated Cross-Talk

The transient receptor potential family V1 channel (TRPV1) is activated by multiple stimuli, including capsaicin, acid, endovanilloids, and heat (>42C). Post-translational modifications to TRPV1 result in dynamic changes to the sensitivity of receptor activation. We have previously demonstrated that β-arrestin2 actively participates in a scaffolding mechanism to inhibit TRPV1 phosphorylation, thereby reducing TRPV1 sensitivity. In this study, we evaluated the effect of β-arrestin2 sequestration by G-protein coupled receptors (GPCRs) on thermal and chemical activation of TRPV1. Here we report that activation of mu opioid receptor by either morphine or DAMGO results in β-arrestin2 recruitment to mu opioid receptor in sensory neurons, while activation by herkinorin does not. Furthermore, treatment of sensory neurons with morphine or DAMGO stimulates β-arrestin2 dissociation from TRPV1 and increased sensitivity of the receptor. Conversely, herkinorin treatment has no effect on TRPV1 sensitivity. Additional behavioral studies indicate that GPCR-driven β-arrestin2 sequestration plays an important peripheral role in the development of thermal sensitivity. Taken together, the reported data identify a novel cross-talk mechanism between GPCRs and TRPV1 that may contribute to multiple clinical conditions.
Association between the 8-item Morisky Medication Adherence Scale (MMAS-8) and blood pressure control.

BACKGROUND Non-adherence to treatment is an important and often unrecognized risk factor that contributes to reduced control of blood pressure (BP). OBJECTIVE To determine the association between treatment adherence measured by a validated version in Portuguese of the 8-item Morisky Medication Adherence Scale (MMAS-8) and BP control in hypertensive outpatients. METHODS A cross-sectional study was carried out with hypertensive patients older than 18 years, treated at six of the Family Health Strategy Units in Maceió (AL), through interviews and home blood pressure measurements, between January and April 2011. Adherence was determined by MMAS-8 version translated for this study. The patients were considered adherent when they had a score equal to 8 at the MMAS-8. RESULTS The prevalence of adherence among the 223 patients studied was 19.7%, while 34% had controlled BP (> 140/90 mmHg). The average adherence value according to the MMAS-8 was 5.8 (± 1.8). Adherent patients showed to be more prone (OR = 6.1, CI [95%] = 3.0 to 12.0) to have blood pressure control than those who reached mean (6 to <8) or low values (<6) at the adherence score. The Portuguese version of MMAS-8 was showed a significant association with BP control (p = 0.000). CONCLUSION The diagnosis of non-adherent behavior through the application of MMAS-8 in patients using of antihypertensive medications was predictive of elevated systolic and diastolic BP.
The forgotten treasure: bilingualism and Asian children's emotional and behavioral health.

OBJECTIVES We investigated the relation between the language status of children and their behavioral and emotional well-being during their early school years. METHODS Behavioral and emotional well-being were drawn from teacher-reported data and included externalizing and internalizing behaviors. Three-level growth curve analyses were conducted on a subsample (n = 12 586) of children from the Early Childhood Longitudinal Study, kindergarten cohort, who originated from Asian countries. US-born, non-Hispanic White children served as the comparison group. RESULTS All children started with a similar level of internalizing and externalizing behaviors at kindergarten entry. The growth rate of problem behaviors was slowest in fluent bilingual and non-English-dominant bilingual children compared with White English-monolingual children. By contrast, problem behaviors increased at a significantly faster rate in non-English-monolingual children, who had the highest level of problem behaviors among all children by fifth grade. CONCLUSIONS By fifth grade, fluent bilingual and non-English-dominant bilingual children had the lowest levels of internalizing and externalizing behaviors, whereas non-English-monolingual children had the highest levels of both behavior problems. Our data suggest emotional and behavioral benefits of being bilingual.
The effect of kinetin on the chlorophyll pigments content in leaves of Zea mays L. seedlings and accumulation of some metal ions

In this work the relationship between the accumulation of some metals, the content of chlorophyll a and b in leaves of Zea mays L. plants, growth of seedlings and concentration of kinetin in medium has been studied. The experiments were carried out with 7-day old maize plants grown on the Hoagland’s medium. The seedlings were exposed to the solution containing kinetin in different concentration (10−9÷10−5 mol · dm−3). The accumulation of metals in maize leaves was measured by emission spectroscopy using the spectrometer with excitation by argon inductively coupled plasma technique (ICP-OES). The amount of chlorophyll pigment was determined by the spectrophotometer UV-Vis. The study shows that kinetin changes the uptake and accumulation of metal ions in leaves of maize plants, changes the growth of seedlings, has influence on the seeds germinations and productivity of fresh and dry mass, and decreases the chlorophyll pigments content in leaves of Zea mays L.
Validation Guidelines for IS Positivist Research

The issue of whether IS positivist researchers were validating their instruments sufficiently was initially raised fifteen years ago. Rigor in IS research is still one of the critical scientific issues facing the field. Without solid validation of the instruments that are used to gather data on which findings and interpretations are based, the very scientific basis of the profession is threatened. This study builds on four prior retrospectives of IS research that conclude that IS positivist researchers continue to face major barriers in instrument, statistical, and other forms of validation. It goes beyond these studies by offering analyses of the state-of-the-art of research validities and deriving specific heuristics for research practice in the validities. Some of these heuristics will, no doubt, be controversial. But we believe that it is time for the IS academic profession to bring such issues into the open for community debate. This article is a first step in that direction. Based on our interpretation of the importance of a long list of validities, this paper suggests heuristics for reinvigorating the quest for validation in IS research via content/construct validity, reliability, manipulation validity, and statistical conclusion validity. New guidelines for validation and new research directions are offered.
Regulation of seasonal variability of aminopeptidase activities in surface and bottom waters of Uranouchi Inlet, Japan

The potential aminopeptidase activity (APA) vis-a-vis important ecological parameters of surface and bottom waters of Uranouchi Inlet (Japan), a semi-enclosed eutrophic coastal ecosystem, were studied on a weekly to biweekly basis from mid-August 1996 to early November 1997. The aim of this study was to investigate the main factors regulating the annual and seasonal dynamics of APA in the inlet. APA was estimated in short-term incubations as the V, of the rate of enzymatic hydrolysis of a fluorophore 7-L-leucyl-4-methyl couomarinylarnide under conditions close to those of in situ. The water column structure at the study site changed considerably during the study period as the ecological parameters such as temperature, dissolved oxygen (DO), nutrient contents, and bacterial abundance exhibited pronounced seasonal stratification (May to September). When the water column was mixed (October to March), surface and bottom waters possessed similar APA . But when the water column became stratified, pronounced differences became apparent, with surface water showing considerably higher APA. On extreme days, surface water possessed as much as -20 times higher APA than that of bottom water. Thus, APA of surface water demonstrated strong seasonality and varied by almost 40-fold compared to that of bottom water, which varied only about 12-fold during the study period. Notably, bacterial abundances of both waters showed limited seasonality and varied only -3-fold during the same period. These results imply that changes in APA are not merely a function of bacterial abundance but rather more of per-cell activity. On an annual basis, APA in both waters were positively correlated (p 0.05) with DO, chlorophyll a (p 0.05) content. In contrast, when the water column became stratified, APA correlated only marginally with temperature (0.01 c p 0.05) with APA regardless of whether the water column was mixed or stratified. These correlations suggest that temperature played a critical role in regulating the APA when the water column was mixed (October to March), and DO or inorganic nutrient contents (May to September) when the water colun~n was stratified.