Miracle-dz/UniFAR-FTUs huggingface dataset:
Population change in Iran 1966-86: a stalled demographic transition?

A researcher used censuses and surveys to analyze 1966-1976 and 1976-1986 population data to compare population growth and fertility of Iran under the Shah with those of theocratic Iran. Between 1966-1976 the government introduced policies which improved the legal and social status of women and promoted fertility control. These resulted in a reduction in the annual population growth rate from 3.1-2.7%. In fact the crude birth rate fell from 49-42.7. Yet the rural birth rate (49.1) was still 1 of the highest in the world. A rising age at marriage contributed to the fall in fertility. For example in 1966 46.5% of 15-19 year old women were married compared to 34.2% in 1976. In fact the singulate mean age of marriage increased from 18.4-19.7. Further the percentage of women of reproductive age who were married decreased 81-75% between 1966-1976. Moreover age specific fertility rates fell for all 20-40 year old women. Indeed total fertility declined from 7.7-6.3. This was more pronounced in urban areas (6.9-4.4). As a result of the Iranian Revolution and the Iran-Iraq war population size increased rapidly from 33.7-49.4 million (1976-1986)--3.8% annual growth rate. Further the crude birth rate increased 12% (1986 47.6). In addition at least 1.8 million people from Afghanistan sought refuge in Iran. Moreover the age at 1st marriage was not any higher than in 1986 than it was in 1976. In fact the government reduced the legal age to 9 for females and 14 for males. Further it abolished the family planning council. In addition the proportion of 15-59 year old married women only decreased 3% between 1976-1986 compared to 6% between 1976-1986. Age specific fertility rates increased significantly especially for 40-44 year olds (32%). Further total fertility rose to 7 and the increase was especially high in urban areas (16% increase compared to 8% in rural areas). As of the end of 1991 there were indications that the government recognized the population problem and had taken steps to promote family planning.
Isoflurane delays the development of early brain injury after subarachnoid hemorrhage through sphingosine-related pathway activation in mice*

Objective:Isoflurane, a volatile anesthetic agent, has been recognized for its potential neuroprotective properties and has antiapoptotic effects. We examined whether isoflurane posttreatment is protective against early brain injury after subarachnoid hemorrhage and determined whether this effect needs sphingosine-related pathway activation. Design:Controlled in vivo laboratory study. Setting:Animal research laboratory. Subjects:One hundred seventy-nine 8-wk-old male CD-1 mice weighing 30–38 g. Interventions:Subarachnoid hemorrhage was induced in mice by endovascular perforation. Animals were randomly assigned to sham-operated, subarachnoid hemorrhage–vehicle, and subarachnoid hemorrhage+2% isoflurane. Neurobehavioral function and brain edema were evaluated at 24 and 72 hrs. The expression of sphingosine kinase, phosphorylated Akt, and cleaved caspase-3 was determined by Western blotting and immunofluorescence. Neuronal cell death was examined by terminal deoxynucleotidyl transferase–mediated uridine 5′-triphosphate-biotin nick end-labeling staining. Effects of a sphingosine kinase inhibitor N, N-dimethylsphingosine or a sphingosine 1 phosphate receptor inhibitor VPC23019 on isoflurane’s protective action against postsubarachnoid hemorrhage early brain injury were also examined. Measurements and Main Results:Isoflurane significantly improved neurobehavioral function and brain edema at 24 hrs but not 72 hrs after subarachnoid hemorrhage. At 24 hrs, isoflurane attenuated neuronal cell death in the cortex, associated with an increase in sphingosine kinase 1 and phosphorylated Akt, and a decrease in cleaved caspase-3. The beneficial effects of isoflurane were abolished by N, N-dimethylsphingosine and VPC23019. Conclusions:Isoflurane posttreatment delays the development of postsubarachnoid hemorrhage early brain injury through antiapoptotic mechanisms including sphingosine-related pathway activation, implying its use for anesthesia during acute aneurysm surgery or intervention.
Violent Video Games and Reciprocity : The Attenuating Effects of Cooperative Game Play on Subsequent Aggression

Numerous studies have shown that playing violent video games alone increases subsequent aggression. However, social game play is becoming more popular than solo game play, and research suggests cooperative game play is beneficial for players. The current studies explore the effects of cooperative game play on player’s subsequent aggressive behaviors toward video game partners (Experiment 1) and non-video game partners (Experiment 2), while providing a discussion of possible theories applicable to social video game play. Cooperative games resulted in less aggression between video game partners (Experiment 1) and between non-video game partners (Experiment 2) than did competitive or stand-alone games. Interestingly, cooperative game play and no-game play produced similar levels of aggression (Experiment 1), whereas competitive and solo game play produced similar levels of aggression (Experiment 2). These findings are consistent with the theory of bounded generalized reciprocity. Playing violent games cooperatively can offset the aggressionincreasing effects of violent video games. 1Texas Tech University, Lubbock, USA 2University of Innsbruck, Tyrol, Austria 3University of Arizona, Tucson, USA 4The Ohio State University, Columbus, USA 5VU University, Amsterdam, The Netherlands Corresponding Author: John A. Velez, Department of Journalism and Electronic Media, College of Media & Communication, Texas Tech University, Box 43082, Lubbock, TX 79409, USA. Email: john.velez@ttu.edu 552519 CRXXXX10.1177/0093650214552519Communication ResearchVelez et al. research-article2014 at University of Portsmouth on August 10, 2015 crx.sagepub. com Downloaded from 2 Communication Research
Board characteristics and corporate value: evidence from Thailand

Purpose – This paper aims to examine the influence of corporate board structure on corporate value.Design/methodology/approach – The data were collected on a sample of 245 Thai non‐financial listed companies to examine the effect of board structure on firm performance.Findings – The results show that neither independent directors nor grey directors are the significant determinants of improving firm value.Research limitations/implications – This research was confined to 245 Thai non‐financial listed companies. It would be useful to replicate it using larger samples under different country settings.Practical implications – The findings provide guidance to top managers in deciding the Board structure as corporate value is also grounded in corporate board structure.Originality/value – The paper provides far reaching implications for corporate managers about the relationship between Board characteristics and corporate value.
The OECD and global governance in education

This review essay discusses the history, evolution and development of the Organisation for Economic Co-operation and Development (OECD) and traces the growing impact of its education work. The essay is in four main sections. The first discusses Carrol and Kellow’s The OECD: A Study of Organizational Adaptation (Edward Elgar) and provides a brief historical account of the Organisation. The second section reviews Woodward’s The Organisation for Economic Co-operation and Development (Routledge) and considers the different modes of governance employed by the OECD, particularly its exercise of soft power through peer review. The third section considers Tucker’s edited book, Surpassing Shanghai: An Agenda for American Education Built on the World’s Leading Systems (Harvard Education Press) and the effects that Shanghai-China’s 2009 (PISA) success has had on education policy debates in the USA and globally. The final section engages with Sahlberg’s Finnish Lessons: What Can the World Learn From Educational Change in Finland? (Teachers College Press) and describes factors that have contributed to the high quality and equity of schooling in Finland. The review essay thus moves from an examination of the role and function of the OECD in general terms to more specific discussion of the recent impact of its PISA, which has drawn attention to particular school systems and has influenced education policy-making in both member and non-member countries. We conclude by providing a framework for understanding the epistemological and infrastructural governance functions of the OECD in education globally.
Managerial Discretion and Accounting for Research and Development Costs

This study investigates the extent to which potential financial reporting benefits from capitalizing and amortizing R&D costs depend on increasing the level of discretion permitted to financial statement preparers. To provide evidence on this issue, we examine the impact of alternative accounting schemes for R&D costs on the extent to which earnings and book values jointly explain the observed distribution of share prices. One alternative requires firms to capitalize and amortize R&D outlays, but provides them with no more discretion than that permitted under current rules. The other alternatives reflect increasing discretion over which R&D costs are recognized as assets and the periods over which these assets are amortized. We find that ability to explain the distribution of share prices increases with discretion, and conclude that substantial managerial discretion is likely to be a necessary (though not sufficient) ingredient of any alternative R&D accounting scheme that is capable of producing economically significant financial reporting benefits.
A Dynamic Structural Model for Stock Return Volatility and Trading Volume

This paper seeks to develop a structural model that lets data on asset returns and trading volume speak to whether volatility autocorrelation comes from the fundamental that the trading process is pricing or, is caused by the trading process itself. Returns and volume data argue, in the context of our model, that persistent volatility is caused by traders experimenting with different beliefs based upon past profit experience and their estimates of future profit experience. A major theme of our paper is to introduce adaptive agents in the spirit of Sargent (1993) but have them adapt their strategies on a time scale that is slower than the time scale on which the trading process takes place. This will lead to positive autocorrelation in volatility and volume on the time scale of the trading process which generates returns and volume data. Positive autocorrelation of volatility and volume is caused by persistence of strategy patterns that are associated with high volatility and high volume. Thee following features seen in the data: (i) The autocorrelation function of a measure of volatility such as squared returns or absolute value of returns is positive with a slowly decaying tail. (ii) The autocorrelation function of a measure of trading activity such as volume or turnover is positive with a slowly decaying tail. (iii) The cross correlation function of a measure of volatility such as squared returns is about zero for squared returns with past and future volumes and is positive for squared returns with current volumes. (iv) Abrupt changes in prices and returns occur which are hard to attach to 'news. ' The last feature is obtained by a version of the model where the Law of Large Numbers fails in the large economy limit.
Antibody‐ and complement‐independent phagocytotic and cytolytic activities of human macrophages toward porcine cells

Abstract: Background: It has been speculated that host macrophages contribute to rapid clearance of transplanted xenogeneic cells. To address such a possibility, phagocytotic and cytolytic activities of human macrophages toward xenogeneic porcine cells were evaluated in vitro in the absence of antibodies and complement factors.
Immunohistochemical expression of CDX2, &bgr;‐catenin, and TP53 in inflammatory bowel disease‐associated colorectal cancer

Background: Inflammatory bowel disease (IBD) exposes patients to an increased risk of colorectal cancer (i‐CRC) and differences between i‐CRC and sporadic colorectal cancer (s‐CRC) pathogenesis were reported. In s‐CRC, studies indicate abnormalities in the tumor‐suppressor gene Cdx2. This study compared CDX2, &bgr;‐catenin, and TP53 expression in i‐CRC, s‐CRC, noncancer IBD, and normal control colonic mucosa. Methods: Expression was investigated by immunohistochemistry in 10 normal, 20 s‐CRC, 11 noncancer colonic IBD and 30 i‐CRC samples, and in four samples of Crohn's disease (CD)‐associated small bowel adenocarcinoma (i‐SBA). Results: In normal and noncancer IBD samples, CDX2 was confined to the colonocytes nuclei. CDX2 expression was normal in 90% of i‐CRC, regardless of tumor differentiation or inflammation intensity. By contrast, CDX2 expression was altered in 45% s‐CRC, particularly at the front of invasion in undifferentiated tumors. &bgr;‐Catenin was restricted to cell membrane in all controls, in 91% noncancer IBD, and in 84% i‐CRC samples, whereas 35% s‐CRC showed cytoplasmic redistribution and exclusive nuclear staining at the front of invasion. TP53 was strongly and homogeneously expressed in i‐CRC nuclei compared to normal control or s‐CRC, and increases with inflammation intensity. Nested or diffuse TP53 was found in 81.8% of noncancer IBD samples with a higher proportion of TP53‐expressing cells in the most inflamed samples. CDX2, &bgr;‐catenin, and TP53 expression in CD‐associated SBA appears similar to that of i‐CRC. Neither Cdx2 nor &bgr;‐catenin alterations are prominent features of i‐CRC. Conclusions: In i‐CRC and CD‐associated SBA, carcinogenesis is associated early with p53 mutations and to inflammation intensity. (Inflamm Bowel Dis 2011;)
Effect of hydration on exercise-induced growth hormone response.

DESIGN Growth hormone (GH) has demonstrated water-retaining effects in subjects at rest, whereas other research has indicated that GH may stimulate sweating. Thus, the aim of this study was to investigate the effect of fluid intake on the exercise-induced GH response. METHODS Seven healthy male volunteers (age: 27.4+/-1.3 years, weight: 74.5+/-1.1 kg, height: 179.3+/-2.3 cm) performed a 40-min submaximal rectangular cycling exercise in two different sessions. The first session (Session 1) was performed without water intake, and the second (Session 2) involved the ingestion of spring water (four intakes) corresponding to the volume of water lost during the first session. RESULTS In session 1, the water loss was 568+/-32 ml. In Session 2, the volume of water loss was not significantly different from the volume of fluid intake (524+/-16 versus 568+/-32 ml respectively). The decrease in plasma volume was significantly reduced in Session 2 (-6.69+/-1.59% versus -11.3+/-1.89%; P<0.05). In Session 1, the GH concentration was significantly lower than that during Session 2 after 25 min (3.04+/-1.05 versus 5.26+/-1.81; P<0.05) and after 40 min (13.7+/-3.55 versus 17.60+/-4.14 ng/ml; P<0.05) of exercise. The total GH response was significantly lower in Session 1 than in Session 2 (136.6+/-39.2 versus 202.4+/-58.9 ng/ml x min; P<0.05). CONCLUSIONS We conclude that the exercise-induced GH response decreases when exercise is performed without fluid intake.
Endocrine disrupting potential and reproductive dysfunction in male mice exposed to deltamethrin

Pesticide exposure may affect semen quality and male fertility in humans. The aim of the present work was to elucidate the adverse effects of deltamethrin (Delta), a synthetic pyrethroid, on exposed male mice and their offspring. Adult male Albino/Swiss mice received deltamethrin (5 mg/kg) daily for 35 days and mated with untreated females to produce offspring. Classical measurements of ejaculate and sperm quality and testicular histopathological changes were assessed. Deltamethrin treatment affects sperm quality and quantity in the ejaculated semen of mice that had also markedly impaired libido as measured by indices of mating and fertility and number of pregnant females housed with male mice exposed to this pesticide. Exposure mice to deltamethrin significantly decreased their testosterone and inhibin B levels and affected reproductive performance. Testes of exposed mice showed marked histopathological alterations as compared to the control group. The mice exposed to 5 mg/kg body weight/day of deltamethrin showed severe alterations of the seminiferous tubules, sloughing of the germ cells, the vacuolization of germ cell cytoplasm, and the disruption of spermatogenic cells compared to the control group. Altered pregnancy outcomes were directly attributed to damage of sperm of male mice exposed to deltamethrin compared to the control group. We concluded that exposure to deltamethrin affected the reproductive system of male mice explored by altered total sperm density, motility, and morphology in mice spermatozoa.
Unexpectedly High Proportion of Ancestral Manu Genotype Mycobacterium tuberculosis Strains Cultured from Tuberculosis Patients in Egypt

ABSTRACT Tuberculosis is one of the important public health problems in Egypt. However, limited information on the Mycobacterium tuberculosis genotypes circulating in Egypt is available. A total of 151 M. tuberculosis strains were characterized by spoligotyping. The results revealed that 74.8% of M. tuberculosis isolates grouped into 13 different clusters, while 25.2% had unique spoligotype patterns. Comparison with an international spoligotyping database (the SITVIT2 database) showed that types SIT53 (T1 variant) and SIT54 (Manu2 variant) were the most common types between cluster groups. In addition, new shared types SIT2977, SIT2978, and SIT2979 were observed. The results identified for the first time an unusually high proportion of ancestral Manu strains of M. tuberculosis from patients in Egypt. The percentage of the Manu clade in this study (27.15%) was significantly higher than its overall representation of 0.4% in the SITVIT2 database. We show that in Egypt tuberculosis is caused by a predominant M. tuberculosis genotype belonging to the ancestral Manu lineage which could be a missing link in the split between ancestral and modern tubercle bacilli during the evolution of M. tuberculosis.
Polycentric Urban Development: The Case of Hangzhou

Despite the advantages of polycentric structure and its rich literature drawn from cities in industialized countries, little attention has been paid to the study of polycentric urban development in developing countries based on land-use information. With Hangzhou used as a case study, the authors investigate polycentric urban development through an analysis of directions of urban expansion, urban–rural gradients, and growth types. The multidisciplinary methodology employed, based on theories and methods in remote sensing, geographic information systems, and landscape ecology, has been proved to be useful in the morphological study of polycentric urban development. It was found that Hangzhou has expanded in different directions at various speeds, shifting to a polycentric urban pattern through radial expansion. Along the main transportation corridors, the values of the mean patch sizes of urban patches displayed multiple peaks, and the landscape-shape index maintained a horizontal trend in urban fringes, reflecting the formation of polycentricity. Further, as edge growth and spontaneous growth accounted for 40%–50% and 30–40% of urban growth, respectively, and infill growth was responsible for only a small proportion of urban growth, it is suggested that dispersed urban patches have been increasingly agglomerated into big ones, especially along road corridors. Hangzhou's polycentric urban development was shaped both by the planning efforts of the government and by market forces. The municipal government guided the polycentric development through drafting and revising master plans, annexing nearby districts, and establishing development zones. Nevertheless, market forces played an increasingly important role in Hangzhou's polycentric development through the implementation of an urban land market, the inflow of migrant workers, and the relocation of industries.
Effect of 18 months of treatment with alfacalcidol on bone in patients with mild to moderate chronic renal failure.

BACKGROUND The bone abnormalities that lead to symptomatic renal osteodystrophy commence early in the course of renal failure, but the optimal time to start treatment needs clarifying. The present study examined the effect of alfacalcidol treatment on bone metabolism and bone density in patients with pre-dialysis chronic renal failure (CRF) in a prospective, randomized, placebo-controlled double blind design. METHODS Repetitive measures of bone mineral density (BMD) estimated by dual energy X-ray absorptiometry and plasma levels of biochemical markers of bone turnover [osteocalcin, bone alkaline phosphatase, propeptide of type-I collagen (PICP) and telopeptide of type-I collagen] and parameters of calcium homeostasis were performed in 36 patients with a glomerular filtration rate (GFR) of 6-60 ml/min. RESULTS A significant difference in BMD between the treatment groups in favour of the alfacalcidol-treated patients was found in the spine (4.2%), the femoral neck (4.9%) and the total femur (3.0%) (P<0.05). In the alfacalcidol group, plasma levels of parathyroid hormone 1-84 decreased from baseline values by 47+/-9%, and p-osteocalcin and bone alkaline phosphatase decreased by 24+/-9% and 48+/-8%, respectively (P<0.05). In the placebo group, PICP increased by 32+/-26% (P<0.05). No significant changes were found in plasma levels of vitamin D metabolites. GFR decreased significantly from baseline values in the alfacalcidol group (by 28+/-4 ml/min) and in the placebo group (by 26+/-5 ml/min) (P<0.05), with no difference being detected between the groups. CONCLUSIONS Long-term treatment with alfacalcidol is safe and might be beneficial for the preservation of bone mass in the pre-dialysis stages of CRF, most likely through a reduction in bone turnover as estimated from the changes of the biochemical bone markers.
Cylindrical ultrasonic transducers for cardiac catheter ablation

This study was designed to evaluate the feasibility of using cylindrical ultrasound transducers mounted on a catheter for the ablation of cardiac tissues. In addition, the effects of ultrasound frequency and power was evaluated both using computer simulations and in vitro experiments. Frequencies of 4.5, 6, and 10 MHz were selected based on the simulation studies and manufacturing feasibility. These transducers were mounted on the tip of 7-French catheters and applied in vitro to fresh ventricular canine endocardium, submerged in flowing degassed saline at 37/spl deg/C. When the power was regulated to maintain transducer interface temperature at 90-100/spl deg/C, the 10-, 6-, and 4.5-MHz transducers generated a lesion depth of 5.9/spl plusmn/0.2 mm, 4.6/spl plusmn/1.0 mm, and 5.3/spl plusmn/0.9 mm, respectively. The 10-MHz transducer was chosen for the in vivo tests since the maximum lesion depth was achieved with the lowest power. Two dogs were anesthetized and sonications were performed in both the left and right ventricles. The 10-MHz cylindrical transducers caused an average lesion depth of 6.4/spl plusmn/2.5 mm. In conclusion, the results show that cylindrical ultrasound transducers can be used for cardiac tissue ablation and that they may be able to produce deeper tissue necrosis than other methods currently in use.