Miracle-dz/UniFAR-FTUs huggingface dataset:
OH in the coastal boundary layer of Crete during MINOS: Measurements and relationship with ozone photolysis

Abstract. Hydroxyl radical (OH) concentrations were measured in August 2001 at Finokalia Station on the northeastern coast of Crete during the Mediterranean Intensive Oxidant Study (MINOS). OH was measured based on selected ion chemical ionization mass spectrometry (SI/CIMS) with a time resolution of 30 sec and signal integration of 5 min. The corresponding accuracy, precision, and detection limit were 20% (1σ), 11% (1σ), and 2.4 x 105 molecules cm-3 (2σ), respectively. OH levels showed a strong diurnal variability with high maxima (approximately 2 x 107 molecules cm-3) occurring around 13:30 LT (10:30 UTC) and nighttime values below the detection limit. Daily 24-hour average concentrations varied between 3.6-6.7 x 106 cm-3. For the total measurement period (6-21 August) the mean and standard deviation were 4.5 ± 1.1 x 106 cm-3. The OH data set is analyzed based on a classification into three periods: I: Aug 6-8, II: Aug 9-11, III: Aug 13-18. For each of the three periods the measured OH concentrations are described by the empirical function [OH] = a J(O1D)b, with J(O1D) being the ozone photolysis frequency and a = 1.4 x 1010 s cm-3, 1.7 x 1010 s cm-3, 2.2 x 1010 s cm-3, and b = 0.68, respectively. Taking into account the estimated precision of the OH measurements this empirical function using three values for a and one value for b explains 99% of the observed variance of OH. A detailed sensitivity analysis using a CH4-CO box model was performed to interpret this relationship, in particular the meanings of the pre-exponential factor a and the exponent b. It was found that the value of b which represents the total logarithmic dependence of [OH] on J(O1D) includes the individual contributions from the photolysis of O3, NO2, HCHO, HONO, and H2O2 which could be determined using the box model. For the conditions prevailing during the MINOS campaign the exponent b was found to be dominated by the contributions from O3- and NO2-photolysis. For the individual functional dependences between [OH] and J(O1D), [OH] and J(NO2), and J(NO2) and J(O1D) the partial logarithmic derivatives were determined to be 0.5, 0.6, and 0.3, respectively. Overall, the box model yields a value of 0.70 for the exponent b in very good agreement with the corresponding value derived from the empirical analysis of the measurements. This empirical approach in which the chemical air mass characteristics influencing the OH radical balance and thereby, the self-cleansing efficiency of the atmosphere, are represented by only two parameters which are constant over quite substantial time periods may be used in future experiments to test and compare OH measurements made in different atmospheric environments.
A Crucial Role for p57Kip2 in the Intracellular Timer that Controls Oligodendrocyte Differentiation

The intracellular molecular mechanism that controls the timing of oligodendrocyte differentiation remains unknown. Temple and Raff (1986) previously showed that an oligodendrocyte precursor cell (OPC) can divide a maximum of approximately eight times before its daughter cells simultaneously cease proliferating and differentiate into oligodendrocytes. They postulated that over time the level of an intracellular molecule might synchronously change in each daughter cell, ultimately reaching a level that prohibited additional proliferation. Here, we report the discovery of such a molecule, the cyclin-dependent kinase inhibitor p57Kip2 (Cdkn1c). We show in vitro that all daughters of a clone of OPCs express similar levels of p57Kip2, that p57Kip2 levels increase over time in proliferating OPCs, and that p57Kip2 levels regulate how many times an OPC can divide before differentiating. These findings reveal a novel part of the mechanism by which OPCs measure time and are likely to extend to similar timers in many other precursor cell types.
An experimental study of the Saffman-Taylor instability

An experiment on the Saffman-Taylor instability with wetting fluids is presented that explores a greater range of capillary numbers than did the original experiment of Saffman and Taylor. It turns out that no clear one-half plateau for the finger size is observed, and that the ensemble of experiments cannot be analysed in terms of a single control parameter. The effect of the film of oil left behind the finger is important, and we measure its thickness. A qualitative discussion of the instabilities of the fingers for large capillary numbers is presented, the first instability leading to asymmetrical fingers. Tip splitting appears for larger values of 1/B. The 1/B value for the onset of instabilities is shown to be noise dependent.
Evaluation of Near-Tropopause Ozone Distributions in the Global Modeling Initiative Combined Stratosphere/Troposphere Model with Ozonesonde Data

The NASA Global Modeling Initiative has de- veloped a combined stratosphere/troposphere chemistry and transport model which fully represents the processes govern- ing atmospheric composition near the tropopause. We evalu- ate model ozone distributions near the tropopause, using two high vertical resolution monthly mean ozone profile clima- tologies constructed with ozonesonde data, one by averag- ing on pressure levels and the other relative to the thermal tropopause. At the tropopause, model ozone is high-biased in the SH tropics and NH midlatitudes by 45% in a 4 lat- itude ◊5 longitude model simulation. Doubling the res- olution to 2 ◊2.5 increases the NH high bias to 60%, and reduces the tropical bias to 30%, apparently due to decreased horizontal transport between the tropics and ex- tratropics in the higher-resolution simulation. These ozone biases do not appear to be due to an overly vigorous resid- ual circulation, insufficient convection, or excessive strato- sphere/troposphere exchange, and so may be due to insuffi- cient vertical resolution or excessive vertical diffusion near the tropopause. In the upper troposphere and lower strato- sphere, model/measurement intercomparisons are strongly affected by the averaging technique. Compared to the pressure-averaged climatology, NH and tropical mean model lower stratospheric biases are <20%. In the upper troposphere, the 2 ◊2.5 simulation shows mean high biases of 20% and 35% during April in the trop- ics and NH midlatitudes, respectively. This apparently good model/measurement agreement degrades when relative-to- tropopause averages are considered, with upper troposphere high biases of 30% and 70% in the tropics and NH mid- latitudes. This occurs because relative-to-tropopause averag- ing better preserves the larger cross-tropopause O 3 gradients which are seen in the daily sonde data, but not in daily model profiles. Relative-to-tropopause averages therefore more ac- curately reveal model/measurement discrepancies. The rela- tive annual cycle of ozone near the tropopause is reproduced very well in the model Northern Hemisphere midlatitudes. In the tropics, the model amplitude of the near-tropopause an- nual cycle is weak. This is likely due to the annual amplitude of mean vertical upwelling near the tropopause, which anal- ysis suggests is 30% weaker than in the real atmosphere.
Modeling the electromechanical interactions in a null-flux electrodynamic maglev system

The fundamental electromechanical interactions in a passive null-flux electrodynamic maglev system (EDS) are mediated by the voltages induced in the levitation coils by the sled magnets, and by the forces exerted on the sled as a result of the induced currents. This work presents a reliable and compact method to calculate these interactions by using analytical expressions of the magnetic field of a permanent magnet. The proposed approach provides a highly efficient and numerically stable approach to the computation of the flux induced in the levitation coils as well as the induced voltages and currents and lift, drag, and guidance forces acting on the sled's magnets. The analytical model is compared to a simplified algebraic model suitable for real-time control of EDS maglev suspension dynamics. Both models are compared with measurements and show good predictive quality.
Exploring Early Stages of the Chemical Unfolding of Proteins at the Proteome Scale

After decades of using urea as denaturant, the kinetic role of this molecule in the unfolding process is still undefined: does urea actively induce protein unfolding or passively stabilize the unfolded state? By analyzing a set of 30 proteins (representative of all native folds) through extensive molecular dynamics simulations in denaturant (using a range of force-fields), we derived robust rules for urea unfolding that are valid at the proteome level. Irrespective of the protein fold, presence or absence of disulphide bridges, and secondary structure composition, urea concentrates in the first solvation shell of quasi-native proteins, but with a density lower than that of the fully unfolded state. The presence of urea does not alter the spontaneous vibration pattern of proteins. In fact, it reduces the magnitude of such vibrations, leading to a counterintuitive slow down of the atomic-motions that opposes unfolding. Urea stickiness and slow diffusion is, however, crucial for unfolding. Long residence urea molecules placed around the hydrophobic core are crucial to stabilize partially open structures generated by thermal fluctuations. Our simulations indicate that although urea does not favor the formation of partially open microstates, it is not a mere spectator of unfolding that simply displaces to the right of the folded←→unfolded equilibrium. On the contrary, urea actively favors unfolding: it selects and stabilizes partially unfolded microstates, slowly driving the protein conformational ensemble far from the native one and also from the conformations sampled during thermal unfolding.
Stellar populations in NGC 5128 with the VLT: Evidence for recent star formation

We resolve stars of the nearest giant elliptical galaxy NGC 5128 using VLT with FORS1 and ISAAC. We construct deep U , V and K s color-magnitude and color-color diagrams in two different halo fields (in the halo and in the north-eastern diffuse shell). In the outer, shell field, at ~14 kpc from the center of the galaxy, there is a significant recent star formation with stars as young as 10 Myr, approximately aligned with the prominent radio and X-ray jet from the nucleus of the host AGN. Ionized gas filaments are evident in ultraviolet images near the area where neutral Hi and CO molecular gas was previously observed. The underlying stellar population of the halo of the giant elliptical is predominantly old with a very broad metallicity distribution. The presence of an extended giant branch reaching $M_{\rm bol}=-5$ mag suggests the existence of a significant intermediate-age AGB population in the halo of this galaxy.
Coordinate Regulation of Salmonella Pathogenicity Island 1 (SPI1) and SPI4 in Salmonella enterica Serovar Typhimurium

ABSTRACT Salmonella enterica serovar Typhimurium harbors five pathogenicity islands (SPI) required for infection in vertebrate hosts. Although the role of SPI1 in promoting epithelial invasion and proinflammatory cell death has been amply documented, SPI4 has only more recently been implicated in Salmonella virulence. SPI4 is a 24-kb pathogenicity island containing six open reading frames, siiA to siiF. Secretion of the 595-kDa SiiE protein requires a type I secretory system encoded by siiC, siiD, and siiF. An operon polarity suppressor (ops) sequence within the 5′ untranslated region upstream of siiA is required for optimal SPI4 expression and predicted to bind the antiterminator RfaH. SiiE concentrations are decreased in a SPI1 mutant strain, suggesting that SPI1 and SPI4 may have common regulatory inputs. SPI1 gene expression is positively regulated by the transcriptional activators HilA, HilC, and HilD, encoded within SPI1, and negatively regulated by the regulators HilE and PhoP. Here, we show that mutations in hilA, hilC, or hilD similarly reduce expression of siiE, and mutations in hilE or phoP enhance siiE expression. Individual overexpression of HilA, HilC, or HilD in the absence of SPI1 cannot activate siiE expression, suggesting that these transcriptional regulators act in concert or in combination with additional SPI1-encoded regulatory loci to activate SPI4. HilA is no longer required for siiE expression in an hns mutant strain, suggesting that HilA promotes SPI4 expression by antagonizing the global transcriptional silencer H-NS. Coordinate regulation suggests that SPI1 and SPI4 play complementary roles in the interaction of S. enterica serovar Typhimurium with the host intestinal mucosa.
The Tumultuous Lives of Galactic Dwarfs and the Missing Satellites Problem

Hierarchical cold dark matter (CDM) models predict that Milky Way-sized halos contain several hundred dense low-mass dark matter satellites (the substructure), an order of magnitude more than the number of observed satellites in the Local Group. If the CDM paradigm is correct, this prediction implies that the Milky Way and Andromeda are filled with numerous dark halos. To understand why these halos failed to form stars and become galaxies, we need to understand their history. We analyze the dynamical evolution of the substructure halos in a high-resolution cosmological simulation of Milky Way-sized halos in the ΛCDM cosmology. We find that about 10% of the substructure halos with the present masses ≲108-109 M☉ (circular velocities Vm ≲ 30 km s-1) had considerably larger masses and circular velocities when they formed at redshifts z ≳ 2. After the initial period of mass accretion in isolation, these objects experience dramatic mass loss because of tidal stripping. Our analysis shows that strong tidal interaction is often caused by actively merging massive neighboring halos, even before the satellites are accreted by their host halo. These results can explain how the smallest dwarf spheroidal galaxies of the Local Group were able to build up a sizable stellar mass in their seemingly shallow potential wells. We propose a new model in which all the luminous dwarf spheroidals in the Local Group are descendants of the relatively massive (≳109 M☉) high-redshift systems, in which the gas could cool efficiently by atomic line emission, and which were not significantly affected by the extragalactic ultraviolet radiation. We present a simple galaxy formation model based on the trajectories extracted from the simulation, which accounts for the bursts of star formation after strong tidal shocks and the inefficiency of gas cooling in halos with virial temperatures Tvir ≲ 104 K. Our model reproduces the abundance, spatial distribution, and morphological segregation of the observed Galactic satellites. The results are insensitive to the redshift of reionization.
Therapeutic Value of Combined Therapy with Deferasirox and Silymarin on Iron Overload in Children with Beta Thalassemia

Background Beta thalassemia is an inherited hemoglobin disorder resulting in a severe, chronic anemia requiring life-long blood transfusion that induces iron overload. Silymarin is a flavonoid complex isolated from Silybin marianum with a strong antioxidant activity, inducing an hepatoprotective action, and probably, a protective effect on iron overload. The aim of this work was to determine the silymarin value in improving iron chelation in thalassemic patients with iron overload treated with Deferasirox. Patients and Methods This study was conducted on 40 children with beta thalassemia major under follow-up at Hematology Unit, Pediatric Department, Tanta University Hospital with serum ferritin level more than 1000 ng/ml and was divided into two groups. Group IA: Received oral Deferasirox (Exjade) and silymarin for 6 months. Group IB: Received oral Deferasirox (Exjade) and placebo for 6 months and 20 healthy children serving as a control group in the period between April 2011 and August 2012 and was performed after approval from research ethical committee center in Tanta University Hospital and obtaining an informed written parental consent from all participants in this study. Results Serum ferritin levels were markedly decreased in group IA cases compared with group IB (P= 0.001). Conclusion From this study we concluded that, silymarin in combination with Exjade can be safely used in the treatment of iron-loaded thalassemic patients as it showed good iron chelation with no sign of toxicity. Recommendations We recommend extensive multicenter studies in a large number of patients with longer duration of follow-up and more advanced techniques of assessment of iron status in order to clarify the exact role of silymarin in reducing iron overload in children with beta thalassemia.
The biggest extension of rights in Europe? Needs, rights and children with additional support needs in Scotland

ABSTRACT The Education (Additional Support for Learning) (Scotland) Act 2004 boosted the rights of parents of children with additional support needs (ASN) by improving access to information, instituting a Code of Practice and establishing new redress mechanisms such as the ASN Tribunal and independent mediation. More than a decade later, Scottish legislation enacted in 2016 and implemented in 2018 attempted to increase children’s rights, broadly placing them on a par with those of parents and young people. This paper draws on data from an ESRC project entitled Autonomy, Rights and Children with Special Needs: A New Paradigm? (ES/P002641/1). Analysis of Scottish Government policy and legislation, key informant interviews and official statistics are used to examine the extent to which the new rights are likely to be realised in practice, given the complexity of the legislation and competition between discourses of needs, broadly synonymous with the wellbeing agenda and rights. The paper concludes with a discussion of the lessons which may be learnt from the Scottish experience, which will be of interest to an international audience.
The Role of the Subgenual Anterior Cingulate Cortex and Amygdala in Environmental Sensitivity to Infant Crying

Newborns and infants communicate their needs and physiological states through crying and emotional facial expressions. Little is known about individual differences in responding to infant crying. Several theories suggest that people vary in their environmental sensitivity with some responding generally more and some generally less to environmental stimuli. Such differences in environmental sensitivity have been associated with personality traits, including neuroticism. This study investigated whether neuroticism impacts neuronal, physiological, and emotional responses to infant crying by investigating blood-oxygenation-level dependent (BOLD) responses using functional magnetic resonance imaging (fMRI) in a large sample of healthy women (N = 102) with simultaneous skin conductance recordings. Participants were repeatedly exposed to a video clip that showed crying infants and emotional responses (valence, arousal, and irritation) were assessed after every video clip presentation. Increased BOLD signal during the perception of crying infants was found in brain regions that are associated with emotional responding, the amygdala and anterior insula. Significant BOLD signal decrements (i.e., habituation) were found in the fusiform gyrus, middle temporal gyrus, superior temporal gyrus, Broca’s homologue on the right hemisphere, (laterobasal) amygdala, and hippocampus. Individuals with high neuroticism showed stronger activation in the amygdala and subgenual anterior cingulate cortex (sgACC) when exposed to infant crying compared to individuals with low neuroticism. In contrast to our prediction we found no evidence that neuroticism impacts fMRI-based measures of habituation. Individuals with high neuroticism showed elevated skin conductance responses, experienced more irritation, and perceived infant crying as more unpleasant. The results support the hypothesis that individuals high in neuroticism are more emotionally responsive, experience more negative emotions, and may show enhanced cognitive control during the exposure to infant distress, which may impact infant-directed behavior.
Combinatorial Therapy with Neurotrophins and cAMP Promotes Axonal Regeneration beyond Sites of Spinal Cord Injury

Previous attempts to promote regeneration after spinal cord injury have succeeded in stimulating axonal growth into or around lesion sites but rarely beyond them. We tested whether a combinatorial approach of stimulating the neuronal cell body with cAMP and the injured axon with neurotrophins would propel axonal growth into and beyond sites of spinal cord injury. A preconditioning stimulus to sensory neuronal cell bodies was delivered by injecting cAMP into the L4 dorsal root ganglion, and a postinjury stimulus to the injured axon was administered by injecting neurotrophin-3 (NT-3) within and beyond a cervical spinal cord lesion site grafted with autologous bone marrow stromal cells. One to 3 months later, long-projecting dorsal-column sensory axons regenerated into and beyond the lesion. Regeneration beyond the lesion did not occur after treatment with cAMP or NT-3 alone. Thus, clear axonal regeneration beyond spinal cord injury sites can be achieved by combinatorial approaches that stimulate both the neuronal soma and the axon, representing a major advance in strategies to enhance spinal cord repair.
Spiritual Nontroversies: Framing Conflicts and Controversies of Religion and Spirituality in Danish News Media

This article analyzes two Danish news stories in order to discuss the reasons that spirituality seems to be less newsworthy than religion. Drawing on Anderson’s concept of imagined communities, and Luhmann’s account of the mass media in a modern functionally differentiated society, I argue that spirituality seldom registers as controversial in the news stories. It lacks the scale necessary to be selected as newsworthy. Additionally, it is not a natural source of systemic irritation for many subsystems, probably only for the systems of religion and science. The two cases involves media controversies on news production on mindfulness in the health system and on the use of animal telepathy in the majority church.
High Hydrostatic Pressure Induces Counterclockwise to Clockwise Reversals of the Escherichia coli Flagellar Motor

ABSTRACT The bacterial flagellar motor is a reversible rotary machine that rotates a left-handed helical filament, allowing bacteria to swim toward a more favorable environment. The direction of rotation reverses from counterclockwise (CCW) to clockwise (CW), and vice versa, in response to input from the chemotaxis signaling circuit. CW rotation is normally caused by binding of the phosphorylated response regulator CheY (CheY-P), and strains lacking CheY are typically locked in CCW rotation. The detailed mechanism of switching remains unresolved because it is technically difficult to regulate the level of CheY-P within the concentration range that produces flagellar reversals. Here, we demonstrate that high hydrostatic pressure can induce CW rotation even in the absence of CheY-P. The rotation of single flagellar motors in Escherichia coli cells with the cheY gene deleted was monitored at various pressures and temperatures. Application of >120 MPa pressure induced a reversal from CCW to CW at 20°C, although at that temperature, no motor rotated CW at ambient pressure (0.1 MPa). At lower temperatures, pressure-induced changes in direction were observed at pressures of <120 MPa. CW rotation increased with pressure in a sigmoidal fashion, as it does in response to increasing concentrations of CheY-P. Application of pressure generally promotes the formation of clusters of ordered water molecules on the surfaces of proteins. It is possible that hydration of the switch complex at high pressure induces structural changes similar to those caused by the binding of CheY-P.