Miracle-dz/UniFAR-FTUs huggingface dataset:
A study of iterative methods for the solution of systems of linear equations on transputer networks

This thesis is concerned with the parallel, iterative solution of non-singular systems of linear equations, using networks of transputers. We provide an overview of a number of iterative methods designed to solve symmetric and nonsymmetric systems, with emphasis on variants of the Conjugate-Gradients method. These methods are usually used in conjunction with preconditioners, either to achieve convergence of the method for a given system or to accelerate the rate of convergence, or both. In this context we discuss the use of a highly parallel class of preconditioners, the polynomial preconditioners, in the solution of both symmetric and nonsymmetric systems. We show through the solution of a set of test problems that symmetric systems can be effectively solved using the Conjugate-Gradients method coupled with a polynomial preconditioner. Unfortunately for nonsymmetric systems the situation is rather obscure, none of the nonsymmetric iterative solvers studied give a consistently good performance on the set of test problems considered. However we give some experimental evidence that polynomial preconditioners may be used in the nonsymmetric case with some success, even if the conditions of convergence of such preconditioners are not satisfied. We describe the parallelization of some iterative methods along with polynomial preconditioners using rectangular meshes of transputers. Two distinct classes of algorithms are developed, one for generic (dense and sparse) systems and the other for those systems
Tube shunt coverage with gamma-irradiated cornea allograft (VisionGraft)

Purpose To investigate the clinical outcomes of tube shunt coverage using sterile gamma-irradiated cornea allograft. Patients and methods The Wills Eye Hospital Glaucoma Research Center retrospectively reviewed the medical records of 165 patients who underwent glaucoma tube shunt procedures using sterile gamma-irradiated cornea allograft (VisionGraft) between December 2012 and November 2013. Demographic characteristics, type of tube shunt, and position were noted. Complications were recorded at 1 day; 1 week; 1, 3, 6, and 12 months; and on the final postoperative visit. Results One hundred and sixty-nine eyes of 165 patients were included. The mean follow-up time was 4.8±3.5 (ranging from 1 to 16) months. There was no evidence of immunological reaction, infection, or exposure in 166 eyes (98.2%). Three eyes (1.8%) experienced graft or tube exposure within the first 3 postoperative months. Two of the cases had underlying diseases: bullous pemphigoid and chronic allergic conjunctivitis. Conclusion Coverage of tube shunts using gamma-irradiated cornea allograft had a low exposure rate and was well tolerated. The graft can be stored long term at room temperature and has an excellent postoperative cosmetic appearance.
The yips in sport: A systematic review

ABSTRACT The yips are a psycho-neuromuscular movement disorder, which affects sports in which fine motor precision skills are required for success. This review aims to examine key components of the yips within sport literature using a systematic approach. Twenty-five published studies were used in the systematic review, the majority of which focused on the yips in golf (n = 18); case studies were the most popular methodological approach (n = 12). Four components of the yips were identified: psychological, physiological, neurological and performance. This review describes evidence associated with each component according to research design, sample characteristics and main findings. Key findings associated with each component are evaluated and gaps within the existent literature are highlighted. It is concluded that future research incorporates a multi-discipline theory-driven approach on a wider range of sports using a more precise definition of yips types in order to enhance our understanding of the predictors and mechanisms of the yips which, in turn, will allow practitioners to develop effective interventions for athletes.
The role of emotions in marketing

Emotions are mental states of readiness that arise from appraisals of events or one’s own thoughts. In this article, the authors discuss the differentiation of emotions from affect, moods, and attitudes, and outline an appraisal theory of emotions. Next, various measurement issues are considered. This is followed by an analysis of the role of arousal in emotions. Emotions as markers, mediators, and moderators of consumer responses are then analyzed. The authors turn next to the influence of emotions on cognitive processes, which is followed by a study of the implications of emotions for volitions, goal-directed behavior, and decisions to help. Emotions and customer satisfaction are briefly explored, too. The article closes with a number of questions for future research.
CYP3A5 Genotype Impacts Maraviroc Concentrations in Healthy Volunteers

CYP3A5 plays a prominent role in the metabolism of maraviroc, an approved drug for human immunodeficiency virus (HIV)-1 treatment and a candidate for HIV-1 prevention. We studied the effect of the CYP3A5 genotype on pharmacokinetics of maraviroc and a primary CYP3A5-dependent metabolite of maraviroc denoted as metabolite 1 (M1). Volunteers were screened for health status and CYP3A5 genotype (wild-type allele *1 and dysfunctional alleles *2, *3, *6, and *7) to obtain 24 evaluable subjects in three groups (n = 8 each): homozygous dysfunctional (two dysfunctional alleles), heterozygous (one *1 allele and one dysfunctional allele), and homozygous wild-type (two *1 alleles). Subjects received 300 mg maraviroc orally followed by blood collection for 32 hours. The homozygous wild-type group exhibited lower mean plasma maraviroc concentrations at almost all sampling times. The median (interquartile range) maraviroc area under the plasma concentration-time curves from time 0 to infinity (AUC0–inf) were 2099 (1422–2568) ng⋅h/ml, 1761 (931–2640) ng⋅h/ml, and 1238 (1065–1407) ng⋅h/ml for the homozygous dysfunctional, heterozygous, and homozygous wild-type groups, respectively. The homozygous wild-type group had 41% lower maraviroc AUC0–inf and 66% higher apparent clearance compared with the homozygous dysfunctional group (P = 0.02). The AUC0–inf ratios of maraviroc to M1 in heterozygous and homozygous wild-type subjects were lower by 51 and 64% relative to the homozygous dysfunctional group, respectively (P < 0.001). In conclusion, the lower maraviroc concentrations in the homozygous wild-type group indicate that maraviroc may be underdosed in people homozygous for the CYP3A5*1 allele, including almost one-half of African Americans.
Music-evoked incidental happiness modulates probability weighting during risky lottery choices

We often make decisions with uncertain consequences. The outcomes of the choices we make are usually not perfectly predictable but probabilistic, and the probabilities can be known or unknown. Probability judgments, i.e., the assessment of unknown probabilities, can be influenced by evoked emotional states. This suggests that also the weighting of known probabilities in decision making under risk might be influenced by incidental emotions, i.e., emotions unrelated to the judgments and decisions at issue. Probability weighting describes the transformation of probabilities into subjective decision weights for outcomes and is one of the central components of cumulative prospect theory (CPT) that determine risk attitudes. We hypothesized that music-evoked emotions would modulate risk attitudes in the gain domain and in particular probability weighting. Our experiment featured a within-subject design consisting of four conditions in separate sessions. In each condition, the 41 participants listened to a different kind of music—happy, sad, or no music, or sequences of random tones—and performed a repeated pairwise lottery choice task. We found that participants chose the riskier lotteries significantly more often in the “happy” than in the “sad” and “random tones” conditions. Via structural regressions based on CPT, we found that the observed changes in participants' choices can be attributed to changes in the elevation parameter of the probability weighting function: in the “happy” condition, participants showed significantly higher decision weights associated with the larger payoffs than in the “sad” and “random tones” conditions. Moreover, elevation correlated positively with self-reported music-evoked happiness. Thus, our experimental results provide evidence in favor of a causal effect of incidental happiness on risk attitudes that can be explained by changes in probability weighting.
Treatment of Fabry Disease: Outcome of a Comparative Trial with Agalsidase Alfa or Beta at a Dose of 0.2 mg/kg

Background Two different enzyme preparations, agalsidase alfa (ReplagalTM, Shire) and beta (FabrazymeTM, Genzyme), are registered for treatment of Fabry disease. We compared the efficacy of and tolerability towards the two agalsidase preparations administered at identical protein dose in a randomized controlled open label trial. Methodology/Principal Findings Thirty-four Fabry disease patients were treated with either agalsidase alfa or agalsidase beta at equal dose of 0.2 mg/kg biweekly. Primary endpoint was reduction in left ventricular mass after 12 and 24 months of treatment. Other endpoints included occurrence of treatment failure (defined as progression of cardiac, renal or cerebral disease), glomerular filtration rate, pain, anti-agalsidase antibodies, and globotriaosylceramide levels in plasma and urine. After 12 and 24 months of treatment no reduction in left ventricular mass was seen, which was not different between the two treatment groups. Also, no differences in glomerular filtration rate, pain and decline in globotriaosylceramide levels were found. Antibodies developed only in males (4/8 in the agalsidase alfa group and 6/8 in the agalsidase beta group). Treatment failure within 24 months of therapy was seen in 8/34 patients: 6 male patients (3 in each treatment group) and 2 female patients (both agalsidase alfa). The occurrence of treatment failures did not differ between the two treatment groups; χ2 = 0.38 p = 0.54. Conclusion Our study revealed no difference in reduction of left ventricular mass or other disease parameters after 12 and 24 months of treatment with either agalsidase alfa or beta at a dose of 0.2 mg/kg biweekly. Treatment failure occurred frequently in both groups and seems related to age and severe pre-treatment disease. Trial Registration International Standard Randomized Clinical Trial ISRCTN45178534
The Nexus Between Social Capital and Bank Risk Taking

This study explores social capital and its relevance to bank risk taking across countries. Our empirical results show that the levels of bank risk taking are lower in countries with higher levels of social capital, and that the impact of social capital is mainly reflected by the reduced value of the standard deviation of return on assets. Moreover, the impact of social capital is found to be weaker when the legal system lacks strength. Furthermore, the study considers the impacts of social capital of the banks’ largest shareholders in these countries and finds that high levels of social capital present in these countries exert a negative effect on bank risk taking, but the effect is not strongly significant.
Adrenocortical activity in at-risk and normally developing adolescents: Individual differences in salivary cortisol basal levels, diurnal variation, and responses to social challenges

The purpose of this study was to examine adrenocortical activity (basal, diurnal variation, and responses to social stressors) in adolescents at risk for psychopathology. Salivary cortisol levels were examined in normally developing and at-risk youth with internalizing and externalizing symptoms ranging from subclinical to clinical levels. Adolescents showed expected patterns of diurnal variation, with high early morning cortisol levels and a pattern of decline throughout the day. Females showed higher midday and late afternoon levels than males, and these patterns interacted with risk status. Internalizing problems sometimes were associated with gradual rather than steep declines in basal cortisol production. Both immediate and delayed cortisol reactivity to a social performance stressor were associated with internalizing symptoms. There was no evidence of relations between externalizing problems and underarousal of the hypothalamic–pituitary–adrenal (HPA) system. These and other results suggest that gender is an important moderating factor linking psychopathology, development, and context with HPA axis functioning in adolescence.
The ontogenesis of speech acts

ABSTRACT A speech act approach to the transition from pre-linguistic to linguistic communication is adopted in order to consider language in relation to behaviour generally and to allow for an emphasis on the USE of language rather than on its form. The structure of language is seen as non-arbitrary in that it reflects both attention structures (via predication) and action structures (via the fundamental case grammatical form of language). Linguistic concepts are first realized in action. A pilot study focusing on the regulation of JOINT attention and JOINT activity within the context of mutuality between mother and infant is discussed, with emphasis on ritualization in mutual play as a vehicle for understanding the development of the formal structures of language.
Current Issues in Alternative Media Research

Research in alternative media has burgeoned since the turn of the millennium. The majority of studies has examined the political and social dimensions of alternative media and has focused on the media of social movements. The value of these amateur media projects lies not only in the content they produce, but also in the educational and political empowerment they offer to their participants. Other forms of alternative media, such as blogs and fanzines, present challenges to mainstream journalism; they challenge the exclusive authority and expertise of professional journalists. Recent research has begun to examine the relationship between alternative and mainstream media practices, particularly examining how alternative media offer ways of rebalancing media power and how ‘ordinary’ people are able to represent their own lives and experiences and concerns in ways that are often ignored or marginalised by the dominant media institutions. However, we need to learn more about specific alternative media practices and how audiences use their content.
A logic of enumeration: the nature and effects of national literacy and numeracy testing in Australia

This paper reveals the array of practices arising from strong policy pressure for improved student results in national literacy and numeracy tests in Australia: the National Assessment Programme in Literacy and Numeracy (NAPLAN). The paper provides an account of a policy context characterised by significant pressure upon teachers and principals to engage in practices to ensure improved outcomes on standardised literacy and numeracy tests, and of teachers and principals’ responses to these policy pressures. Drawing upon Bourdieu’s theory of practice, the article argues that what is described as the ‘field of schooling practices’ has become increasingly dominated by a ‘logic of enumeration’, and that high test results on standardised literacy and numeracy tests are increasingly valued capitals, evident in a strong focus upon teachers meeting, discussing and informing one another about NAPLAN; engaging in curriculum development practices which foreground NAPLAN, and; actively preparing students to sit the test, including, whether intentionally or unintentionally, teaching to the test. Such a focus has important implications for the sorts of practices most valued in schooling settings, as more educative logics are potentially marginalised under such circumstances.
Social Media(tion) and the Reshaping of Public/Private Boundaries in Employment Relations

Tensions surrounding social media in the employment relationship are increasingly evident in the media, public rhetoric, and courts and employment tribunals. Yet the underlying causes and dimensions of these tensions have remained largely unexplored. This article firstly reviews the available literature addressing social media and employment, outlining three primary sources of contestation: profiling, disparaging posts and blogs, and private use of social media during work time. In each area, the key dynamics and underlying concerns of the central actors involved are identified. The article then seeks to canvas explanations for these forms of contestation associated with social media at work. It is argued that the architecture of social media disrupts traditional relations in organisational life by driving employer and employee actions that (re)shape and (re)constitute the boundaries between public and private spheres. Although employers and employees are using the same social technologies, their respective concerns about and points of entry to these technologies, in contrast to traditional manifestations of conflict and resistance, are asymmetric. The article concludes with a representational summary of the relative legitimacy of concerns for organisational actors and outlines areas for future research.
The pulmonary changes of bleomycin toxicity.

Of 186 patients treated with the antineoplastic drug bleomycin, 5 showed clinical and roentgenographic signs of pulmonary toxicity. Clinical manifestations were dyspnea and decreased total lung capacities. Radiographic findings consisted mainly of interstitial infiltration which resolved in 3 cases and persisted as pathologically proved fibrosis in the other 2.
Sorting Out Pandora’s Box: Discerning the Dynamic Roles of Liver Microenvironment in Oncolytic Virus Therapy for Hepatocellular Carcinoma

Oncolytic viral therapies have recently found their way into clinical application for hepatocellular carcinoma (HCC), a disease with limited treatment options and poor prognosis. Adding to the many intrinsic challenges of in vivo oncolytic viral therapy, is the complex microenvironment of the liver, which imposes unique limitations to the successful delivery and propagation of the virus. The normal liver milieu is characterized by an intricate network of hepatocytes and non-parenchymal cells including Kupffer cells, stellate cells, and sinusoidal endothelial cells, which can secrete anti-viral cytokines, provide a platform for non-specific uptake, and form a barrier to efficient viral spread. In addition, natural killer cells are greatly enriched in the liver, contributing to the innate defense against viruses. The situation is further complicated when HCC arises in the setting of underlying hepatitis virus infection and/or hepatic cirrhosis, which occurs in more than 90% of clinical cases. These conditions pose further inhibitory effects on oncolytic virus (OV) therapy due to the presence of chronic inflammation, constitutive cytokine expression, altered hepatic blood flow, and extracellular matrix deposition. In addition, OVs can modulate the hepatic microenvironment, resulting in a complex interplay between virus and host. The immune system undoubtedly plays a substantial role in the outcome of OV therapy, both as an inhibitor of viral replication, and as a potent mechanism of virus-mediated tumor cell killing. This review will discuss the particular challenges of oncolytic viral therapy for HCC, as well as some potential strategies for modulating the immune system and synergizing with the hepatic microenvironment to improve therapeutic outcome.
Investigating the Role of Internet Self-Efficacy in the Elderly's Learning of ICT in Hong Kong, China: A Two-Part Study

SUMMARY This paper discusses the role of Internet self-efficacy and outcome expectations in the elderly's usage of the Internet through a two-part study. The researchers conducted this study by collaborating with three non-government organizations (NGOs) for which funding was received from one government unit and a large local charitable organization. A new theoretical model was developed to examine the influence of Internet self-efficacy and outcome expectations on usage intention and perceived user competence. Behavioral modeling training courses were offered to mature adults aged 50 and above in two separate studies over a year. Questionnaire surveys and cognitive knowledge assessments were conducted. In general, the findings in the two studies validated the impacts of Internet self-efficacy and outcome expectations on usage intention. Limitations and implications of this study are discussed.
III. IMPACTS OF EARLY HEAD START PARTICIPATION ON CHILD AND PARENT OUTCOMES AT AGES 2, 3, AND 5

Describes the impacts that EHS participation had on children's participation in formal center-based programs after leaving EHS and follow this with a presentation of the impacts of the EHS program for the total sample at three time pointsâ€”when the children were 2, 3, and 5 years old.
Decreased bone mineral density and increased fracture risk in aging men with or at risk for HIV infection

Background:Osteopenia has been described in HIV-infected persons, but most studies have not focused on aging men, have not included an HIV-negative comparison group with similar risks to those of the HIV-infected men, or lacked data on fracture rates. Methods:We analyzed bone mineral density (BMD) and incident fractures in 559 men who were ≥ 49 years old with or at-risk for HIV, including 328 with and 231 without HIV infection. Results:Median age was 55 years, 56% were black and 89% had used illicit drugs. In unadjusted analysis, BMD was lower in HIV-infected compared with HIV-uninfected men at the femoral neck (0.97 ± 0.14 versus 1.00 ± 0.15 g/cm2; P < 0.05) and lumbar spine (1.17 ± 0.20 versus 1.20 ± 0.21 g/cm2; P = 0.06); both differences were significant (P < 0.05) after adjusting for age, weight, race, testosterone level, and prednisone and illicit drug use. Non-black race and body weight were independently associated with BMD at both measurement sites and methadone therapy was independently associated with spine BMD. Among HIV-infected men, 87% had taken antiretrovirals and 74% had taken protease inhibitors, but their use was not associated with BMD. Among men who had at least one subsequent study visit (94%), incident fracture rates per 100 person-years differed among men with normal BMD, osteopenia and osteoporosis (1.4 versus 3.6 versus 6.5; P < 0.01). A 38% increase in fracture rate among HIV-infected men was not statistically significant. Conclusions:HIV infection is independently associated with modestly reduced BMD in aging men, and decreased BMD is associated with increased fracture risk.
Masculinities, Femininities, Behaviour and Health

Using the notion that gender is performed in daily life and through daily activities, I review some of the health behaviour literature which employs ideas about masculinity and femininity. I argue that recent theorising about both masculinities (Connell & Messerschmidt, 2005) and femininities (Schippers, 2007) can be extremely useful in this field. I consider two specific health behaviours in light of this theorising, namely healthy eating and drinking alcohol, and explore how and which versions of masculinities and femininities are played out, which are problematic, and what they mean for gender hegemony. I argue that across both areas (and across other health behaviours), there are three specific issues that are important and require further conceptual development and empirical work: (1) the relationality of gender; (2) masculinities and femininities as embodied; and (3) the local, contingent and intersectional nature of masculinities and femininities. This conceptual framework and the aspects of relationality, embodiment and intersectionality have important implications not only for understanding health behaviours, but for any social psychological work theorising identities and everyday social practice.