Miracle-dz/UniFAR-FTUs huggingface dataset:
Respiration and sleep in Parkinson's disease.

Sir: We have read with great interest the recent paper by Apps etal. ' on respiration and sleep in Parkinson's disease. We were particularly intrigued by the finding of an increase in respiratory rate among the Parkinson subjects compared with control subjects while awake and during REM sleep. It would be important to know if any direct measurement of minute ventilation or end tidal CO2 was performed, that is, whether the tachypnoea was associated with true hyperventilation. Also, we wonder if their subjects had pulmonary function testing, as restrictive lung disease is often accompanied by increased respiratory frequency. The authors appropriately point out that one possibility for this finding is an alteration of ventilatory control in Parkinson's disease. As there is a great deal of evidence that central catecholamines play a role in ventilatory drive,2 this is a very reasonable speculation. We have recently studied ventilatory drive in a group of 14 patients with Parkinson's disease (Hoehn and Yahr stages III-IV) and 11 age matched controls. All subjects had spirometry to rule out significant obstructive or restrictive lung disease. We did not observe changes in resting end tidal CO2 or respiratory rate at rest in our group of Parkinson's patients. However, using rebreathing methods for hyperoxic hypercapnia and isocapnic hypoxia34 we found an increased response in our Parkinson's disease subjects to both hypercapnia and hypoxia.5 It is not yet clear whether this might be a central effect or whether dopamine metabolism in the carotid bodies of these patients is abnormal as well. Further studies of ventilatory drive in Parkinson's disease should be of considerable interest both to expand our knowledge of this disease and to elucidate further the role of catecholamines in respiratory
Mapping White Matter Integrity and Neurobehavioral Correlates in Children with Fetal Alcohol Spectrum Disorders

Brain structural abnormalities and neurocognitive dysfunction have been observed in individuals with fetal alcohol spectrum disorders (FASDs). Little is known about how white matter integrity is related to these functional and morphological deficits. We used a combination of diffusion tensor and T1-weighted magnetic resonance imaging to evaluate white matter integrity in individuals with FASDs and related these findings to neurocognitive deficits. Seventeen children and adolescents with FASDs were compared with 19 typically developing age-and gender-matched controls. Lower fractional anisotropy (FA) was observed in individuals with FASDs relative to controls in the right lateral temporal lobe and bilaterally in the lateral aspects of the splenium of the corpus callosum. White matter density was also lower in some, but not all regions in which FA was lower. FA abnormalities were confirmed to be in areas of white matter in post hoc region of interest analyses, further supporting that less myelin or disorganized fiber tracts are associated with heavy prenatal alcohol exposure. Significant correlations between performance on a test of visuomotor integration and FA in bilateral splenium, but not temporal regions were observed within the FASD group. Correlations between the visuomotor task and FA within the splenium were not significant within the control group, and were not significant for measures of reading ability. This suggests that this region of white matter is particularly susceptible to damage from prenatal alcohol exposure and that disruption of splenial fibers in this group is associated with poorer visuomotor integration.
Resting-State Functional Connectivity in Autism Spectrum Disorders: A Review

Ongoing debate exists within the resting-state functional MRI (fMRI) literature over how intrinsic connectivity is altered in the autistic brain, with reports of general over-connectivity, under-connectivity, and/or a combination of both. Classifying autism using brain connectivity is complicated by the heterogeneous nature of the condition, allowing for the possibility of widely variable connectivity patterns among individuals with the disorder. Further differences in reported results may be attributable to the age and sex of participants included, designs of the resting-state scan, and to the analysis technique used to evaluate the data. This review systematically examines the resting-state fMRI autism literature to date and compares studies in an attempt to draw overall conclusions that are presently challenging. We also propose future direction for rs-fMRI use to categorize individuals with autism spectrum disorder, serve as a possible diagnostic tool, and best utilize data-sharing initiatives.
Territory Occupancy and Parental Quality as Proxies for Spatial Prioritization of Conservation Areas

In order to maximize their fitness, individuals aim at choosing territories offering the most appropriate combination of resources. As population size fluctuates in time, the frequency of breeding territory occupancy reflects territory quality. We investigated the relationships between the frequency of territory occupancy (2002–2009) vs. habitat characteristics, prey abundance, reproductive success and parental traits in hoopoes Upupa epops L. , with the objective to define proxies for the delineation of conservation priority areas. We predicted that the distribution of phenotypes is despotic and sought for phenotypic characteristics expressing dominance. Our findings support the hypothesis of a despotic distribution. Territory selection was non-random: frequently occupied territories were settled earlier in the season and yielded higher annual reproductive success, but the frequency of territory occupancy could not be related to any habitat characteristics. Males found in frequently occupied territories showed traits expressing dominance (i.e. larger body size and mass, and older age). In contrast, morphological traits of females were not related to the frequency of territory occupancy, suggesting that territory selection and maintenance were essentially a male's task. Settlement time in spring, reproductive success achieved in a given territory, as well as phenotypic traits and age of male territory holders reflected territory quality, providing good proxies for assessing priority areas for conservation management.
Intradiskal extravasation with low-volume cement filling in percutaneous vertebroplasty.

BACKGROUND AND PURPOSE Adjacent fracture formation after percutaneous vertebroplasty has been reported in literature. The purpose of this study was to determine whether intervertebral disk extravasation is related to adjacent fracture formation in low-volume cement-filling vertebroplasty. METHODS A retrospective analysis of 308 patients having vertebroplasty was undertaken. Anteroposterior and lateral procedural fluoroscopy radiographs were analyzed for mild, moderate, or severe disk extravasation. Symptomatic refracture location relative to the presence or absence of extravasation was analyzed on follow-up fluoroscopy radiographs. RESULTS Of the 308 patients in the study, 81 patients had disk extravasation at a total of 85 vertebral levels; 40 levels had mild extravasation, 38 levels had moderate extravasation, and 7 had severe extravasation. Of the 40 levels with mild extravasation, 6 new adjacent fractures occurred next to the disk leakage. Of the 38 with moderate extravasation, 6 new adjacent fractures occurred. Of the 7 levels of severe extravasation, only one new adjacent fracture occurred. Hence, a total of 13 adjacent fractures occurred next to disk extravasation; 13 nonadjacent fractures also occurred in the patients with disk extravasation. In the patients without disk extravasation, 28 adjacent and 24 nonadjacent subsequent fractures occurred. The average available cement volumes injected into vertebral bodies causing disk leakage ranged from 4.78 to 5.60 mL. CONCLUSIONS With low-volume cement-filling percutaneous vertebroplasty, we cannot conclude (level of significance alpha = .05) that for patients who have a new fracture there is significance between the location of the fracture and the occurrence of disk extravasation.
Heat and Moisture Production of Poultry and Their Housing Systems: Molting Hens

Heat and moisture production rates (HP, MP) of modern 68to 75-week-old Hy-Line W-36 laying hens during molting were measured using large-scale indirect calorimeters that mimic commercial production settings. The measurements were performed continuously during acclimation, fasting, restricted feeding, and post-molt. Total HP (THP) was partitioned into latent and sensible HP (LHP, SHP) that incorporated influence of fecal moisture evaporation. THP during fasting (averaging 4.8 W/kg) and restricted feeding (averaging 6.0 W/kg) averaged 29% and 13% lower than that during post-molt (averaging 6.8 W/kg). Correspondingly, LHP averaged 1.9 W/kg and 1.8 W/kg and was 31% and 34%, respectively, lower than that (averaging 2.7 W/kg) during post-molt. Likewise, SHP averaged 2.9 W/kg during fasting and was 28% lower than during post-molt (averaging 4.1 W/kg). The average SHP under restricted feeding and post-molt was similar (4.2 vs. 4.1 W/kg, respectively). Respiratory quotient (RQ) averaged 0.71, 0.76, and 0.92 during fasting, restricted feeding, and post-molt, respectively. Heat production rates during the light period were significantly higher (P < 0.05) than those during the dark period. Daily mean and diurnal LHP as percentages of THP were similar during fasting and post-molt but they were 10% lower during restricted feeding. The results of this study provide a new thermal load database for design of housing ventilation systems for laying hens undergoing molting phase.
Dopamine D1 signaling organizes network dynamics underlying working memory

Dopamine orchestrates changes in cortical network synchrony that underlie working memory, as revealed with simultaneous PET-MRI. Local prefrontal dopamine signaling supports working memory by tuning pyramidal neurons to task-relevant stimuli. Enabled by simultaneous positron emission tomography–magnetic resonance imaging (PET-MRI), we determined whether neuromodulatory effects of dopamine scale to the level of cortical networks and coordinate their interplay during working memory. Among network territories, mean cortical D1 receptor densities differed substantially but were strongly interrelated, suggesting cross-network regulation. Indeed, mean cortical D1 density predicted working memory–emergent decoupling of the frontoparietal and default networks, which respectively manage task-related and internal stimuli. In contrast, striatal D1 predicted opposing effects within these two networks but no between-network effects. These findings specifically link cortical dopamine signaling to network crosstalk that redirects cognitive resources to working memory, echoing neuromodulatory effects of D1 signaling on the level of cortical microcircuits.
CHEMICAL COMPOSITION OF PROSOPIS JULIFLORA (SW.) D.C (MOSQUITO BEAN)

Four accessions of the under-exploited legume, Prosopis juliflora (Sw.) D.C (mosquito bean) collected as pod from natural stands of four different agro-climatic regions of Nilgiri Biosphere Reserve (NBR) Western Ghats, Tamil Nadu, India were analyzed for their proximate composition, seed protein fractions, amino acid profiles of total seed proteins, fatty acid profiles, mineral composition, in vitro protein digestibility (IVPD) and certain anti-nutritional factors, to determine their potential as an alternative source to alleviate protein-energy-malnutrition among the people of Tamil Nadu. The crude protein ranged from 26.69 - 29.84%, crude lipid 11.89 - 13.75%, total crude fibre 8.78 - 9.89%, ash 3.99 - 4.95% and carbohydrates 42.45 - 46.37%. The energy level of the seed (1684.94 - 1725.62 kJ100g -1 DM) was comparable with commonly consumed Indian pulses. The albumins and glutelins constitute the major bulk of seed proteins. The essential amino acid profile of total seed proteins compared favorably with FAO/WHO (1991) requirement pattern, except that there were deficiencies of sulphur containing amino acids in all the four accessions. The fatty acid profiles revealed that the seed lipids contained higher concentrations of oleic and linoleic acid. The investigated seeds were rich in minerals such as K, Ca, Mg and P. The IVPD of the four accessions ranged from 50.65 - 63.18%. The range of anti-nutritional factors were as follows: total free phenolics, 4.93 - 8.58%, tannins, 6.81 - 9.15%, L-DOPA, 2.21 - 4.52%, phytic acid, 0.33 - 0.89 g100g -1 , and trypsin inhibitor activity, 40.4 - 48.2 TIU mg -1 protein. Lower levels of phytohaemagglutinating activity for human erythrocytes of "O" blood group than for "A" and "B" blood groups were found. The anti-nutritional fatty acid, behenic acid (0.47 - 1.37%) was also detected.
Economic Evaluation of First-Line Adjuvant Chemotherapies for Resectable Gastric Cancer Patients in China

Background First-line postoperative adjuvant chemotherapies with S-1 and capecitabine and oxaliplatin (XELOX) were first recommended for resectable gastric cancer patients in the 2010 and 2011 Chinese NCCN Clinical Practice Guidelines in Oncology: Gastric Cancer; however, their economic impact in China is unknown. Objective The aim of this study was to compare the cost-effectiveness of adjuvant chemotherapy with XELOX, with S-1 and no treatment after a gastrectomy with extended (D2) lymph-node dissection among patients with stage II-IIIB gastric cancer. Methods A Markov model, based on data from two clinical phase III trials, was developed to analyse the cost-effectiveness of patients in the XELOX group, S-1 group and surgery only (SO) group. The costs were estimated from the perspective of Chinese healthcare system. The utilities were assumed on the basis of previously published reports. Costs, quality-adjusted life-years (QALYs) and incremental cost-effectiveness ratios (ICER) were calculated with a lifetime horizon. One-way and probabilistic sensitivity analyses were performed. Results For the base case, XELOX had the lowest total cost ($44,568) and cost-effectiveness ratio ($7,360/QALY). The relative scenario analyses showed that SO was dominated by XELOX and the ICERs of S-1 was $58,843/QALY compared with XELOX. The one-way sensitivity analysis showed that the most influential parameter was the utility of disease-free survival. The probabilistic sensitivity analysis predicted a 75.8% likelihood that the ICER for XELOX would be less than $13,527 compared with S-1. When ICER was more than $38,000, the likelihood of cost-effectiveness achieved by S-1 group was greater than 50%. Conclusions Our results suggest that for patients in China with resectable disease, first-line adjuvant chemotherapy with XELOX after a D2 gastrectomy is a best option comparing with S-1 and SO in view of our current study. In addition, S-1 might be a better choice, especially with a higher value of willingness-to-pay threshold.
Review Article: Perioperative Care in Enhanced Recovery for Total Hip and Knee Arthroplasty

Enhanced recovery pathways for total hip and knee arthroplasty can reduce length of hospital stay and perioperative morbidity. 22 studies were reviewed for identification of perioperative care interventions, including preoperative (n=4), intra-operative (n=8), and postoperative (n=4) care interventions. Factors that improve outcomes included use of pre-emptive and multimodal analgesia regimens to reduce opioid consumption, identification of patients with poor nutritional status and provision of supplements preoperatively to improve wound healing and reduce length of hospital stay, use of warming systems and tranexamic acid, avoidance of drains to reduce operative blood loss and subsequent transfusion, and early ambulation with pharmacological and mechanical prophylaxis to reduce venous thromboembolism and to speed recovery.
Statistical Arbitrage and Securities Prices

This article introduces the concept of a statistical arbitrage opportunity (SAO). In a finite-horizon economy, a SAO is a zero-cost trading strategy for which (i) the expected payoff is positive, and (ii) the conditional expected payoff in each final state of the economy is nonnegative. Unlike a pure arbitrage opportunity, a SAO can have negative payoffs provided that the average payoff in each final state is nonnegative. If the pricing kernel in the economy is path independent, then no SAOs can exist. Furthermore, ruling out SAOs imposes a novel martingale-type restriction on the dynamics of securities prices. The important properties of the restriction are that it (1) is model-free, in the sense that it requires no parametric assumptions about the true equilibrium model, (2) can be tested in samples affected by selection biases, such as the peso problem, and (3) continues to hold when investors' beliefs are mistaken. The article argues that one can use the new restriction to empirically resolve the joint hypothesis problem present in the traditional tests of the efficient market hypothesis. Copyright 2003, Oxford University Press.
Budaya Gotong Royong Masyarakat Dalam Perubahan Sosial Saat Ini

Artikel ini menguraikan tiga isu pokok: gotong royong sebagai perasan dari Panca Sila dan penerapannya dalam interaksi sosial kehidupan sehari-hari, gotong royong mengandung beberapa unsur-unsur modal sosial serta kondisi masyarakat kontemporer yang berada dalam situasi kekacauan sosial karena lemahnya penerapan nilai-nilai gotong royong dalam interaksi sosial. Di duga perubahan sosial yang cepat serta kuatnya tekanan dari luar, terutama ideologi liberal yang berdasarkan individualis memenjadi penyebab kekacauan sosial. Agenda ke depan untuk menguatkan kembali budaya gotong royong juga dibahas dalam tulisan ini. Kata Kunci: Gotong Royong, Panca Sila, Modal Sosial, Perubahan Sosial
The role of auditory abilities in basic mechanisms of cognition in older adults

The aim of this study was to assess age-related differences between young and older adults in auditory abilities and to investigate the relationship between auditory abilities and basic mechanisms of cognition in older adults. Although there is a certain consensus that the participant’s sensitivity to the absolute intensity of sounds (such as that measured via pure tone audiometry) explains his/her cognitive performance, there is not yet much evidence that the participant’s auditory ability (i.e., the whole supra-threshold processing of sounds) explains his/her cognitive performance. Twenty-eight young adults (age <35), 26 young–old adults (65 í age í 75), and 28 old–old adults (age >75) were presented with a set of tasks estimating several auditory abilities (i.e., frequency discrimination, intensity discrimination, duration discrimination, timbre discrimination, gap detection, amplitude modulation detection, and the absolute threshold for a 1 kHz pure tone) and the participant’s working memory, cognitive inhibition, and processing speed. Results showed an age-related decline in both auditory and cognitive performance. Moreover, regression analyses showed that a subset of the auditory abilities (i.e., the ability to discriminate frequency, duration, timbre, and the ability to detect amplitude modulation) explained a significant part of the variance observed in the processing speed of older adults. Overall, the present results highlight the relationship between auditory abilities and basic mechanisms of cognition.
Global ENSO-streamflow teleconnection, streamflow forecasting and interannual variability

Abstract El Niño Southern Oscillation (ENSO) has been linked to climate anomalies throughout the world. This paper presents an overview of global ENSO-streamflow teleconnection and identifies regions where the relationship may be exploited to forecast streamflow several months ahead. The teleconnection is investigated by fitting a first harmonic to 24-month El Niño streamflow composites from 581 catchments worldwide and the potential for forecasting is investigated by calculating the lag correlation between streamflow and two indicators of ENSO. The analyses indicate clear ENSO-streamflow teleconnections in many catchments, some of which are consistent across large geographical regions. Strong and regionally consistent ENSO-streamflow teleconnections are identified in Australia and New Zealand, South and Central America, and weaker signals are identified in some parts of Africa and North America. The results suggest that the ENSO-streamflow relationship and the serial correlation in streamflow can be used to successfully forecast streamflow. The streamflow forecasts can be used to help manage water resources, particularly in systems with high interannual variability in Australia, southern and drier parts of Africa and some areas of North America.
Automatic Secret Keys From Reciprocal MIMO Wireless Channels: Measurement and Analysis

Information theoretic limits for random key generation in multiple-input multiple-output (MIMO) wireless systems exhibiting a reciprocal channel response are investigated experimentally with a new three-node MIMO measurement campaign. As background, simple expressions are presented for the number of available key bits, as well as the number of bits that are secure from a close eavesdropper. Two methods for generating secret keys are analyzed in the context of MIMO channels and their mismatch rate and efficiency are derived. A new wideband indoor MIMO measurement campaign in the 2.51- to 2.59-GHz band is presented, whose purpose is to study the number of available key bits in both line-of-sight and nonline-of-sight environments. Application of the key generation methods to measured propagation channels indicates key generation rates that can be obtained in practice for four-element arrays.
Trends and correlates in meat consumption patterns in the US adult population

Abstract Objective Few studies have examined recent shifts in meat consumption (MC), differences among US population groups, and the influence of psychosocial–behavioural factors. Design Nationally representative data collected for US adults aged ≥18 years in the 1988–1994 and 1999–2004 National Health and Nutrition Examination Survey (NHANES) and the 1994–1996 Continuing Survey of Food Intakes by Individuals (CSFII) and Diet and Health Knowledge Survey (DHKS) were used. Results We found a U-shaped trend in MC, a decrease between 1988–1994 and 1994–1996, and an increase from 1994–1996 to 1999–2004. NHANES 1988–1994 and 1999–2004 indicate that MC did not change significantly, particularly for all meat, red meat, poultry and seafood. Between 1994–1996 and 1999–2004, average MC, including red meat, poultry, seafood and other meat products, increased in men. Women’s total MC decreased, mainly due to decreased red meat and other meat products, except for increased seafood. Noticeable differences existed in the changes across population groups. Black men had the largest increase in consumption of total meat, poultry and seafood; Mexican American men had the smallest increase in poultry, seafood and other meat products. In 1999–2004, ethnic differences in MC became greater in women than among women in 1994–1996. Associations between MC and energy intake changed over time. Perceived benefit of dietary quality and food label use were associated with reduced red MC. Conclusions Noticeable differences exist in the shifts in MC across population groups and surveys. MC increased in men but decreased in women in recent years.