Miracle-dz/UniFAR-FTUs huggingface dataset:
A critical analysis of the Chiari 1.5 malformation.

OBJECT Although the traditional nomenclature used to describe hindbrain hernias is useful, there are certainly patients in whom these morphological entities do not strictly apply. One such group is composed of patients with the more recently described Chiari 1.5 malformation in which a Chiari I malformation is seen in combination with brain-stem herniation through the foramen magnum. In an attempt to elucidate further the best surgical strategy and to refine the descriptive terminology, the authors retrospectively analyzed all cases at their institutions in which this form of hindbrain herniation was diagnosed. METHODS The authors reviewed the database for all patients in whom Chiari 1.5 malformation had been diagnosed. Each patient had undergone a posterior fossa decompressive surgery. Magnetic resonance images were evaluated for the extent of caudal descent of the brainstem, amount of tonsillar ectopia, inclination of the odontoid process, and any brain or brainstem abnormalities. Clinical presentations and postoperative results were correlated to the aforementioned radiological findings. Twenty-two patients were identified. The obex was a mean 14.4 mm inferior to the foramen magnum, and the medulla exhibited a flattened appearance in the midsagittal plane in all patients. Syringomyelia was documented in 50% of the cases. The cerebellar tonsils were found to lie at C-1 and C-2 in nine and 13 patients, respectively. The mean angulation of the odontoid process was 84.4 degrees. No abnormalities or caudal descent of the midbrain or pons was identified. Eighteen patients experienced resolution of preoperative symptoms. Persistence of syringomyelia prompted a second posterior fossa operation secondary to progressive scoliosis in 13.6% of the patients. CONCLUSIONS No single sign or symptom was found to be peculiar to the Chiari 1.5 malformation, although all patients in whom this diagnosis was established had undergone a posterior fossa decompressive surgery. A significant number (13.6%) of patients required repeated operation for persistent syringomyelia. Neurosurgeons may wish to consider that many patients may not respond as well to posterior fossa decompressive surgery especially if syringomyelia is present.
Users or Supporters? Understanding Motivations and Behaviors of Museum Members

Research into museum membership schemes and their members is limited and fragmented. This study presents an overview of existing research as a contextual framework for a study of the motivations and behavior of members of a British national museum. The paper examines factors such as members' motives for joining, their usage of benefits, the value they place on membership, and their feelings about the host organization. It concludes with advice as to how membership managers can more effectively manage their own membership organization.
Reframing the Roma: EU Initiatives and the Politics of Reinterpretation

Since the accession of the A8 post-communist countries to the European Union, various EU institutions have regularly expressed deep concern about the precarious political, social and economic position of the Roma. This article examines the recent political reinterpretations that accompany the EU's framing of the Roma as a group in need of special attention. It argues that EU institutions will have to find ways to deal with the ambivalence inherent in their ‘European’ appeals for tackling the problems at hand. These calls may indeed—as, for example, the European Commission insists—enhance cooperation between different levels of government and persuade member-states to adopt new policies that will benefit Romani citizens. But, somewhat paradoxically, they also provide new discursive material for nationalist politicians with an anti-Romani agenda who try to minimise or evade their countries’ domestic responsibility by highlighting the role and responsibility of the EU. They also latch onto the alleged ‘Europeanness’ of the Roma in order to exclude them symbolically from their own national space and frame them not only as ‘Europeans’ but also as ‘outsiders’ and ‘cultural deviants’.
Mapping quantitative trait loci for milk production traits on ovine chromosome 6

Spanish Churra sheep were studied in a daughter design for the presence on chromosome 6 of quantitative trait loci (QTL) influencing milk production traits. Eight half-sib families were genotyped for 11 microsatellites and marker-QTL effects analysed using yield deviations (YD) as quantitative measurements for the following traits: milk yield, protein yield, and protein percentage. QTL analysis was performed by interval mapping based on multimarker regression principles. Significance thresholds were estimated through a permutation test followed by a correction for multiple testing. The results suggest a region on ovine chromosome 6, close to the casein cluster, with an influence on milk traits and particularly on protein percentage. These results, the first ones reported for QTL affecting milk traits in sheep, are discussed in relation to data available for cattle, a closely related species.
Cultural differences and entrepreneurial behaviour: an intra-country cross-cultural analysis in Cape Verde

Two recent research trends give rise to the current work: the need to extend the conclusions reached in entrepreneurship studies to other cultural contexts, particularly important given the interest in stimulating the creation of firms in recently industrialised and less developed countries; and the need to go beyond the axiom ‘nation=culture’ in favour of the multiple cultures perspective. With these antecedents, we present the current work, which aims to answer two research questions: (1) are the cultural values associated in the literature with venture creation generalisable to different cultural contexts? (2) are there intra-cultural differences in a country generating differences in the entrepreneurial behaviour of its population? Thus, this work contributes to extending knowledge about entrepreneurship and international cross-cultural management by taking the novel approach of studying the cultural values and the decision to create a venture from the intra-cultural differences perspective. A sample of 448 individuals, obtained in the Republic of Cape Verde and analysed in six territories within this country, allows us to confirm the existence of cultural differences in individualism between regions of the Republic of Cape Verde, as well as their capacity to explain entrepreneurial behaviour in these regions.
An Unusual Appearance of Double Right Coronary Artery

Double right coronary artery (RCA) is an extremely rare coronary artery anomaly. We aimed to report an atherosclerotic double RCA which appeared after primary percutaneous intervention performed to treat acute inferior myocardial infarction. This is the first case in the literature, which the coronary arteries that can be accepted as double RCA have been hidden by total atherosclerotic occlusion of the proximal part of the RCA. In this paper, also the definition, correct diagnosis, and appropriate diagnostic methods for double RCA were discussed.
Social-Emotional Development, School Readiness, Teacher–Child Interactions, and Classroom Environment

This article investigates the effectiveness of a statewide 6-month early childhood mental health consultation (ECMHC) model on teachers’ emotional support of children and classroom organization. We provide a brief historical and theoretical background of the field of ECMHC, present the logic model for our ECMHC intervention, and discuss the existing research that supports this logic model. Research Findings: Participants included 445 teachers from 158 child care centers statewide. The mental health consultation improved the quality of early childhood teachers’ interactions (e.g., emotional support and classroom organization) with children in their care. Teachers with more experience and more than a high school degree tended to score higher on many of the Classroom Assessment Scoring System (R. C. Pianta, K. M. La Paro, & B. K. Hamre, 2008) dimensions. Practice or Policy: This study demonstrates that mental health consultants can partner successfully with early childhood educators and provide support that enhances classroom variables associated with high-quality care and positive child outcomes. Even with a high rate of teacher turnover (35%), significant differences were found; this demonstrates the robustness of the ECMHC model in that the effectiveness of this model was not undermined by the chronic problem of staff turnover.
Disparities among Asians and Native Hawaiians and Pacific Islanders with ischemic stroke

Objectives: To evaluate disparities in cardiovascular risk factors among Asians and Native Hawaiians and other Pacific Islanders (NHPI) in Hawaii who are hospitalized with ischemic stroke. Methods: We performed a retrospective study on consecutive patients hospitalized for ischemic stroke at a single tertiary center in Honolulu between 2004 and 2010. The prevalence of cardiovascular risk factors was compared for NHPI, Asians, and whites who were hospitalized for ischemic stroke. Results: A total of 1,921 patients hospitalized for ischemic stroke were studied. NHPI were less likely to be older (odds ratio [OR] 0.95, 95% confidence interval [CI] 0.94–0.96), more likely to be female (OR 1.55, 95% CI 1.07–2.24), and more likely to have diabetes (OR 2.74, 95% CI 1.87–4.00), hypertension (OR 1.98, 95% CI 1.27–3.10), and obesity (OR 1.82, 95% CI 1.25–2.65) than whites. NHPI had higher low-density lipoprotein levels (114 ± 50 mg/dL vs 103 ± 45 mg/dL, p = 0.001) and lower high-density lipoprotein levels (38 ± 11 mg/dL vs 45 ± 15 mg/dL, p < 0.0001) than whites. Compared with Asians, NHPI were less likely to be older (OR 0.95, 95% CI 0.94–0.97) and more likely to have diabetes (OR 1.88, 95% CI 1.35–2.61), previous stroke or TIA (OR 1.57, 95% CI 1.09–2.25), and obesity (OR 6.05, 95% CI 4.31–8.48). Conclusions: Asians, NHPI, and whites with ischemic stroke have substantially different cardiovascular risk factors. Targeted secondary prevention will be important in reducing disparities among these racial groups.
Association of injection drug use with incidence of HIV-associated non-AIDS-related morbidity by age, 1995–2014

Objective:Incidence of HIV-associated non-AIDS (HANA) related comorbidities is increasing in HIV-infected individuals. Our objective was to estimate the risk of HANA comorbidity associated with history of injection drug use (IDU) correctly accounting for higher death rates among people who inject drugs (PWID). Design:We followed HIV-infected persons aged 25–59 years who enrolled in the Johns Hopkins HIV Clinical Cohort between 1995 and May 2014, from enrollment until HANA comorbidity diagnosis, death, age 60, or administrative censoring. Methods:We compared cumulative incidence (‘risk’), by age, of validated diagnoses of HANA comorbidities among HIV-infected PWID and non-IDU; specifically, we considered end-stage renal disease (ESRD), end-stage liver disease (ESLD), myocardial infarction, stroke, and non-AIDS-defining cancer. We used competing risk methods appropriate to account for death, standardized to the marginal distribution of baseline covariates, and adjusted for potential differential loss-to-clinic. Results:Of 5490 patients included in this analysis, 37% reported IDU as an HIV transmission risk. By age 55 years, PWID had higher risk of ESLD [risk difference = 6.8, 95% confidence interval (CI): −1.9, 15.5] and ESRD (risk difference = 11.1, 95% CI: 1.2, 21.0) than did non-IDU. Risk of myocardial infarction and stroke were similar among PWID and non-IDU. Risk of non-AIDS-defining cancer was lower among PWID than among non-IDU (risk difference at 55 years: −4.9, 95% CI: −11.2, 1.3). Conclusion:Not all HANA comorbidities occur with higher incidence in PWID compared with non-IDU. However, higher incidence of ESRD and ESLD among PWIDs highlights the importance of recognition and management of markers of these comorbidities in early stages among PWID.
Relapse prevention in alcohol aftercare: effects on drinking outcome, change process, and aftercare attendance.

Summary Aftercare contributes to improved drinking outcome, yet maintenance has been overlooked as a point for intervention. This project evaluated the effect of cognitive-behavioural relapse prevention (RP) and interpersonal process (IP) aftercare groups for recently hospitalized alcoholics, consisting of eight weekly 90 min sessions delivered by three co-therapy teams conducting one group in each condition. Six cohorts of patients were assigned to conditions (N=39) and assessed at pretreatment, post-treatment, and 6 month follow-up. RP and IP resulted in comparable improvement/outcome on alcohol consumption, alcohol-related impairment, cognitive coping, drinking days, time to first drink, abstinence, and aftercare attendance. In secondary analyses, improvement on temptation was attributed to RP, on behavioural coping to IP, and effects on self-efficacy appeared marginally related to greater short term improvement for RP. The lack of differential outcome is discussed with respect to inadequate power, possible ceiling effects in outcome, the brevity of the follow-up period, and the possibility that treatments may have been more similar in implementation than intended. Suggestions for improving aftercare and relapse prevention research are presented.
Student-Teacher Contracting with Goal Setting for Maintenance

This study evaluated the use of student goal setting as a strategy for maintaining the effects of student-teacher contracting on the academic productivity of eight economically disadvantaged high school dropouts between the ages of 16 and 21. The study was conducted during the students' basic education skills training class, where students worked in self-paced textbooks in preparation for the GED test. During baseline, students were paid for each hour they attended school. During contracting, students negotiated weekly work requirements with their teacher and were paid contingent on contract fulfillment. Employing a single-subject reversal design, the results showed that student-teacher contracting was effective in increasing student productivity substantially. Subsequently, a multiple-baseline design across students was employed to evaluate the necessity for, and effectiveness of, student goal setting as a strategy for maintaining productivity. During goal setting, students wrote their own work contracts without teacher feedback and were paid contingent on contract completion. The results indicated that goal setting for reponse maintenance proved effective.
Deletion mutants in the gene encoding the herpes simplex virus type 1 immediate-early protein ICP0 exhibit impaired growth in cell culture

We report the construction and characterization of deletion mutants in the herpes simplex virus type 1 gene encoding the immediate-early protein ICP0. In the event that ICP0 proved to play an essential role in virus replication, ICP0-transformed Vero cells were generated to serve as permissive hosts for such mutants. Two mutants, dlX0.7 and dlX3.1, were isolated in these cells by a marker rescue-transfer procedure involving the rescue of an ICP4 deletion mutant and the simultaneous insertion of a linked deletion in the ICP0 gene. Mutant dlX0.7 contained a 700-base-pair deletion in both copies of ICP0. The deletion lay entirely within the transcript specified by the gene. dlX0.7 induced the synthesis of an ICP0-specific mRNA that was approximately 0.7 kilobases smaller than the corresponding mRNA specified by wild-type virus. The 3.1-kilobase deletion in both copies of the ICP0 gene in mutant dlX3.1 removed the majority of the transcriptional-regulatory signals and coding sequences, retaining only sequences at the 3' end of the gene. As expected, no ICP0-specific mRNA was detected in dlX3.1-infected Nero cells (G418-resistant Vero cells). Both mutants grew in all cells tested, although their burst sizes were 10- to 100-fold lower than that of wild-type virus. Although the plaque sizes of dlX0.7 and dlX3.1 were equally small on Nero and ICP0-transformed cells, the plating efficiency of the mutants was 15- to 50-fold greater on ICP0-transformed cells than on Nero cells. The mutants exhibited modest interference with the growth of wild-type virus in mixed infections, an effect that was abolished by UV irradiation of the mutants, implying that interference required viral gene expression. Polypeptide profiles generated by the mutants in Nero cells were qualitatively similar to that of wild-type virus. Quantitatively, only slight reductions in the levels of certain late viral polypeptides were observed, a phenomenon also borne out by analysis of viral glycoproteins. Both mutants induced the synthesis of significant, although reduced, levels of viral DNA relative to wild-type virus. Taken together, the results demonstrate that ICP0 is not essential for productive infection in cell culture but that this protein plays a significant role in viral growth, as indicated by the impaired abilities of the mutants to replicate.
The impact of perceptions and stereotypes on the managerial mobility of African Americans.

Although African Americans have made progress in reaching middle and upper management positions, a disproportionate number are stalled in lower levels of management where their remuneration often lags behind that of Whites in comparable positions. Further penetration into executive ranks may depend largely on the perceptions and attitudes of employers. Negative stereotypes held by top managers may have a deleterious effect on African American opportunities. Among a sample of White middle managers, Schein's (1973, 1975) descriptive index revealed a significant resemblance between ratings of Whites and ratings of managers (r' = .54), whereas the resemblance between ratings of Blacks and ratings of managers was nonsignificant (r' = .17). Managers were perceived to possess characteristics more commonly ascribed to Whites than to African Americans.
The Role of Polyamines in Supporting Growth of Mammalian Cells Is Mediated through Their Requirement for Translation Initiation and Elongation*♦

Polyamines are essential cell constituents whose depletion results in growth cessation. Here we have investigated potential mechanisms of action of polyamines in supporting mammalian cell proliferation. We demonstrate that polyamines regulate translation both at the initiation and at the elongation steps. l-α-Difluoromethylornithine treatment resulting in polyamine depletion reduces protein synthesis via inhibition of translation initiation. N1-Guanyl-diaminoheptane (GC7), a spermidine analogue that inhibits eukaryotic initiation factor 5A (eIF5A) hypusination, also caused inhibition of translation initiation. In contrast, depletion of eIF5A by short hairpin RNA inhibits translation elongation as was recently demonstrated in yeast and Drosophila. These results suggest that in addition to competing with spermidine in the hypusination reaction, GC7 also competes with spermidine at yet undefined sites required for translation initiation. Finally, we show that either polyamine depletion or GC7 treatment induced eIF2α phosphorylation and reduced phosphorylation of 4E-BP, thus setting the molecular basis for the observed inhibition of translation initiation.
Foreign Language Anxiety's Forgotten Study: The Case of the Anxious Preservice Teacher

This article argues that nonnative preservice teachers are just as susceptible to foreign language anxiety as are inexperienced language learners, a claim carrying important implications for the EFL classroom. The results of the study described in this article indicate that anxious preservice teachers experience significant levels of language anxiety to a degree that may cause them to avoid using the target language and language-intensive teaching practices in their classrooms. The article also proposes steps toward helping preservice teachers cope with and hopefully overcome their language anxiety.
Floquet stability analysis of the longitudinal dynamics of two hovering model insects

Because of the periodically varying aerodynamic and inertial forces of the flapping wings, a hovering or constant-speed flying insect is a cyclically forcing system, and, generally, the flight is not in a fixed-point equilibrium, but in a cyclic-motion equilibrium. Current stability theory of insect flight is based on the averaged model and treats the flight as a fixed-point equilibrium. In the present study, we treated the flight as a cyclic-motion equilibrium and used the Floquet theory to analyse the longitudinal stability of insect flight. Two hovering model insects were considered—a dronefly and a hawkmoth. The former had relatively high wingbeat frequency and small wing-mass to body-mass ratio, and hence very small amplitude of body oscillation; while the latter had relatively low wingbeat frequency and large wing-mass to body-mass ratio, and hence relatively large amplitude of body oscillation. For comparison, analysis using the averaged-model theory (fixed-point stability analysis) was also made. Results of both the cyclic-motion stability analysis and the fixed-point stability analysis were tested by numerical simulation using complete equations of motion coupled with the Navier–Stokes equations. The Floquet theory (cyclic-motion stability analysis) agreed well with the simulation for both the model dronefly and the model hawkmoth; but the averaged-model theory gave good results only for the dronefly. Thus, for an insect with relatively large body oscillation at wingbeat frequency, cyclic-motion stability analysis is required, and for their control analysis, the existing well-developed control theories for systems of fixed-point equilibrium are no longer applicable and new methods that take the cyclic variation of the flight dynamics into account are needed.
Deriving a Hoare-Floyd logic for non-local jumps from a formulae-as-types notion of control

We derive a Hoare-Floyd logic for non-local jumps and mutable higher-order procedural variables from a formul{\ae}-as-types notion of control for classical logic. The main contribution of this work is the design of an imperative dependent type system for non-local jumps which corresponds to classical logic but where the famous consequence rule is still derivable.
REGIONAL LUNG FUNCTION IN PATIENTS WITH MITRAL STENOSIS STUDIED WITH XENON-133 DURING AIR AND OXYGEN BREATHING.

blood flow per unit volume of lung is several times greater in the lower zones of the lungs than in the upper (1, 2). Dollery and West (3) have shown that in patients with mitral stenosis this pattern is often reversed and that the upper zones may have several times the blood flow per unit volume of the lower zones. Two explanations for this finding have been suggested. West, Dollery, and Heard (4) have shown that a similar reversal of flow pattern can be produced in an isolated dog lung by sustained elevation of the pulmonary vein pressure, causing perivascular edema in the dependent portion. They suggested that a similar process may cause the increased vascular resistance in the lower zones in patients with mitral stenosis. Another theory proposes that vascular engorgement and edema in the lung bases cause a local loss of compliance or an increase in airway resistance, and the resultant underventilation and hypoxia could cause vasoconstriction in these regions (5). This is consistent with the observations that oxygen breathing can reduce vascular resistance in some cases of mitral stenosis (6-8) and that infusion of acetylcholine into the pulmonary artery may simultaneously lower pulmonary arterial pressure and reduce arterial oxygen saturation (5, 9, 10). The fall in arterial saturation was attributed to the relief of hypoxic vasoconstriction in underventilated lung units (9).