Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of interleaved and blocked study on delayed test of category learning generalization

Studying different concepts by frequently alternating between them (i.e., interleaving), improves discriminative contrast between different categories, while studying each concept in separate blocks emphasizes the similarities within each category. Interleaved study has been shown to improve learning of high similarity categories by increasing between-category comparison, while blocked study improves learning of low similarity categories by increasing within-category comparison. In addition, interleaved study presents greater temporal spacing between repetitions of each category compared to blocked study, which might present long-term memory benefits. In this study we asked if the benefits of temporal spacing would interact with the benefits of sequencing for making comparisons when testing was delayed, particularly for low similarity categories. Blocked study might be predicted to promote noticing similarities across members of the same category and result in short-term benefits. However, the increase in temporal delay between repetitions inherent to interleaved study might benefit both types of categories when tested after a longer retention interval. Participants studied categories either interleaved or blocked and were tested immediately and 24 h after study. We found an interaction between schedule of study and the type of category studied, which is consistent with the differential emphasis promoted by each sequential schedule. However, increasing the retention interval did not modulate this interaction or resulted in improved performance for interleaved study. Overall, this indicates that the benefit of interleaving is not primarily due to temporal spacing during study, but rather due to the cross-category comparisons that interleaving facilitates. We discuss the benefits of temporal spacing of repetitions in the context of sequential study and how it can be integrated with the attentional bias hypothesis proposed by Carvalho and Goldstone (2014a).
A FIRST ORDER ALL PASS FILTER AND ITS APPLICATION IN A QUADRATURE OSCILLATOR

This paper presents an all pass voltage mode filter based on recently proposed active building block namely differential voltage current conveyor transconductance amplifier (DVCCTA). The proposed configuration uses single active and two grounded passive components which makes it suitable for IC implementation. Its input impedance is high and output impedance is low, hence suitable for cascading. The practical design problems due to non-idealities of DVCCTA have also been addressed. Moreover, as an application, a quadrature oscillator is designed using the proposed all pass circuit which provides both voltage and current outputs. SPICE simulation using 0.25 μm TSMC CMOS technology parameters are included to show the workability.
Insulin Signaling in Insulin Resistance States and Cancer: A Modeling Analysis

Insulin resistance is the common denominator of several diseases including type 2 diabetes and cancer, and investigating the mechanisms responsible for insulin signaling impairment is of primary importance. A mathematical model of the insulin signaling network (ISN) is proposed and used to investigate the dose-response curves of components of this network. Experimental data of C2C12 myoblasts with phosphatase and tensin homologue (PTEN) suppressed and data of L6 myotubes with induced insulin resistance have been analyzed by the model. We focused particularly on single and double Akt phosphorylation and pointed out insulin signaling changes related to insulin resistance. Moreover, a new characterization of the upstream signaling of the mammalian target of rapamycin complex 2 (mTORC2) is presented. As it is widely recognized that ISN proteins have a crucial role also in cell proliferation and death, the ISN model was linked to a cell population model and applied to data of a cell line of acute myeloid leukemia treated with a mammalian target of rapamycin inhibitor with antitumor activity. The analysis revealed simple relationships among the concentrations of ISN proteins and the parameters of the cell population model that characterize cell cycle progression and cell death.
Magnetism from 2p states in alkaline earth monoxides : Trends with varying N impurity concentration

$2p$-based magnetic moments and magnetic coupling are studied with density functional based methods for substitutional N in the alkaline earth monoxide series MgO, CaO, SrO, BaO. The hole is rather strongly localized near the N$^{2-}$ ion, being somewhat more so when strong on-site interactions are included in the calculations. Strong magnetic coupling is obtained in the itinerant electron limit but decreases strongly in the localized limit in which the Coulomb repulsion within the N $2p$ shell (U) is much greater than the N $2p$ impurity bandwidth (W). We find that this limit is appropriate for realistic N concentrations. Ordering on a simple cubic sublattice may maximize the magnetic coupling due to its high directionality.
Anti-Mullerian hormone is increased in follicular fluid from unstimulated ovaries in women with polycystic ovary syndrome.

BACKGROUND Anti-Mullerian hormone (AMH) may have a role in disordered folliculogenesis in polycystic ovary syndrome (PCOS). Though there have been several investigations into circulating AMH levels in patients with PCOS, no previous studies have compared AMH concentrations in the follicular fluid of unstimulated ovaries in women with PCOS with that of normally ovulating women. METHODS Follicular fluid was aspirated from 4-8-mm follicles of unstimulated ovaries during routine laparoscopy or laparotomy from women with anovulatory PCOS (n = 11) and those with regular ovulatory cycles (n = 8). Follicular AMH was compared in the two groups. Serum samples were analysed for AMH and endocrine profile. RESULTS Follicular fluid AMH levels were significantly higher (P < 0.0001) in women with anovulatory PCOS (median: 466.2 ng/ml) compared with normal-ovulatory controls (median: 78.0 ng/ml). Mean follicular fluid AMH levels in PCOS patients were 60 times higher than in the serum. Moreover, there was a significant correlation between the follicular fluid and serum concentrations of AMH in the PCOS group (r = 0.86; P = 0.007) but not in controls. CONCLUSIONS Highly elevated AMH in follicular fluid from PCOS patients in contrast to age-matched normal controls suggests that increased circulating concentrations of AMH are partly due to the increased production of AMH by individual follicles and not simply attributable to the increased number of small antral follicles. This suggests an intrinsic abnormality in the ovarian follicles themselves in PCOS, which could contribute to disordered folliculogenesis.
Adverse Selection in Competitive Search Equilibrium

We extend the concept of competitive search equilibrium to environments with private information, and in particular adverse selection. Principals (e.g. employers or agents who want to buy assets) post contracts, which we model as revelation mechanisms. Agents (e.g. workers, or asset holders) have private information about the potential gains from trade. Agents observe the posted contracts and decide where to apply, trading off the contracts' terms of trade against the probability of matching, which depends in general on the principals' capacity constraints and market search frictions. We characterize equilibrium as the solution to a constrained optimization problem, and prove that principals offer separating contracts to attract different types of agents. We then present a series of applications, including models of signaling, insurance, and lemons. These illustrate the usefulness and generality of the approach, and serve to contrast our findings with standard results in both the contract and search literatures.
Novel RF CMOS Integrated Circuits and Systems for Broadband Dielectric Spectroscopy

Broadband dielectric spectroscopy has proven to be a valuable technique for characterization of chemicals and biomaterials. It has the great potential to become an indispensable and cost-effective tool in point-of-care medical applications due to its label-free and non-invasive operation. However, most of the existing dielectric spectroscopy instruments require bulky, heavy and expensive measurement set-up, restricting their use to only special applications in industry and laboratories. Therefore, integrated dielectric spectroscopy on silicon capable of direct detection of chemicals/biomaterials’ complex permittivity can yield significant cost and size reduction, system integration, portability, enormous processing, and high throughput. A CMOS wideband dielectric spectroscopy system is proposed for chemical and biological material characterization. The complex permittivity detection is performed using a configurable harmonic-rejecting receiver capable of indirectly measuring the complex admittance of sensing capacitor exposed to the material-under-test (MUT) and subject to RF signal excitation with a frequency range of 0.62-10 GHz. The sensing capacitor is embedded in a voltage divider topology with a fixed capacitor and the relative variations in the magnitude and phase of the voltages across the capacitors are used to find the real and imaginary parts of the permittivity. The sensor achieves an rms permittivity error of less than 1% over the entire operation bandwidth. Using a sub-harmonic mixing scheme, the system can perform complex permittivity measurements from 0.62 to 10 GHz while requiring an input signal source with frequency range of only from 5 to 10 GHz. Thereby, the permittivity measurement system can be easily made self-sustained by implementing a 5-10 GHz frequency
Making an ecodesign choice in project portfolio selection

Project portfolio management is about selecting the right development projects for a company in order to secure that the company is competitive. However, many companies lack a structured process for selecting new development projects. Several significant decisions are taken in the pre-specification phases of product development. Early decisions are taken that affect the environmental impact of a product. In this paper we describe a proactive environmental design approach. Environmental considerations are included into the process of selecting new project development projects and into the decision preparation phase for product development.
Genetic redundancy of GATA factors in the extraembryonic trophoblast lineage ensures the progression of preimplantation and postimplantation mammalian development

GATA transcription factors are implicated in establishing cell fate during mammalian development. In early mammalian embryos, GATA3 is selectively expressed in the extraembryonic trophoblast lineage and regulates gene expression to promote trophoblast fate. However, trophoblast-specific GATA3 function is dispensable for early mammalian development. Here, using dual conditional knockout mice, we show that genetic redundancy of Gata3 with paralog Gata2 in trophoblast progenitors ensures the successful progression of both pre- and postimplantation mammalian development. Stage-specific gene deletion in trophoblasts reveals that loss of both GATA genes, but not either alone, leads to embryonic lethality prior to the onset of their expression within the embryo proper. Using ChIP-seq and RNA-seq analyses, we define the global targets of GATA2/GATA3 and show that they directly regulate a large number of common genes to orchestrate stem versus differentiated trophoblast fate. In trophoblast progenitors, GATA factors directly regulate BMP4, Nodal and Wnt signaling components that promote embryonic-extraembryonic signaling cross-talk, which is essential for the development of the embryo proper. Our study provides genetic evidence that impairment of trophoblast-specific GATA2/GATA3 function could lead to early pregnancy failure. Summary: During trophoblast development in mice, GATA2 and GATA3 act synergistically by directly regulating a large number of common genes, and together are important to ensure trophoblast lineage progression.
Large-scale patterns in morphological diversity and species assemblages in Neotropical Triatominae (Heteroptera: Reduviidae)

We analysed the spatial variation in morphological diversity (MDiv) and species richness (SR) for 91 species of Neotropical Triatominae to determine the ecological relationships between SR and MDiv and to explore the roles that climate, productivity, environmental heterogeneity and the presence of biomes and rivers may play in the structuring of species assemblages. For each 110 km x 110 km-cell on a grid map of America, we determined the number of species (SR) and estimated the mean Gower index (MDiv) based on 12 morphological attributes. We performed bootstrapping analyses of species assemblages to identify whether those assemblages were more similar or dissimilar in their morphology than expected by chance. We applied a multi-model selection procedure and spatial explicit analyses to account for the association of diversity-environment relationships. MDiv and SR both showed a latitudinal gradient, although each peaked at different locations and were thus not strictly spatially congruent. SR decreased with temperature variability and MDiv increased with mean temperature, suggesting a predominant role for ambient energy in determining Triatominae diversity. Species that were more similar than expected by chance co-occurred near the limits of the Triatominae distribution in association with changes in environmental variables. Environmental filtering may underlie the structuring of species assemblages near their distributional limits.
Chapter 8 The Role of Ultrasound in Hepatic Surgery

Hepatic surgery became the most important field of development of IOUS and nowadays the ultrasounds are employed for several goals: the precise localization of lesions and their relationship with surrounding biliary and vascular structures, the examination of the liver anatomy in order to plan the surgical strategy in respect of the oncologic principles, the in‐ tra-operative re-staging with identification of new nodules.
Discovery of Histamine H3 Antagonists for the Treatment of Cognitive Disorders and Alzheimer's Disease

H3 antagonists increase the release of brain histamine, acetylcholine, noradrenaline, and dopamine, neurotransmitters that are known to modulate cognitive processes. The ability to release brain histamine supports the effect on attention and vigilance, but histamine also modulates other cognitive domains such as short-term and long-term memory. A number of H3 antagonists, including 1-{3-[3-(4-chlorophenyl)propoxy]propyl}piperidine hydrochloride (BF2.649), (1R,3R)-N-ethyl-3-fluoro-3-[3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl]cyclobutane-1-carboxamide (PF-03654746), 6-[(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]-N-methyl-3-pyridinecarboxamide hydrochloride (GSK189254), MK-0249 (structure not yet disclosed), JNJ-17216498 (structure not yet disclosed), and ABT-288 (structure not yet disclosed), have advanced to the clinical area for the potential treatment of human cognitive disorders. H3 antagonists exhibited wake-promoting effects in humans and efficacy in narcoleptic patients, indicating target engagement, but some of them were not efficacious in patients suffering from attention-deficit hyperactivity disorder and schizophrenic patients. Preclinical studies have also shown that H3 antagonists activate intracellular signaling pathways that may improve cognitive efficacy and disease-modifying effects in Alzheimer's disease. Ongoing clinical studies will be able to determine the utility of H3 antagonists for the treatment of cognitive disorders in humans.
Numerical simulation of time-dependent non-Newtonian nano-pharmacodynamic transport phenomena in a tapered overlapping stenosed artery

Nanofluids are becoming increasingly popular in novel hematological treatments and also advanced nanoscale biomedical devices. Motivated by recent developments in this area, a theoretical and numerical study is described for unsteady pulsatile flow, heat and mass transport through a tapered stenosed artery in the presence of nanoparticles. An appropriate geometric expression is employed to simulate the overlapping stenosed arterial segment. The Sisko non-Newtonian model is employed for hemodynamic rheology. Buongiorno’s formulation is employed to model nanoscale effects. The two-dimensional non-linear, coupled equations are simplified for the case of mild stenosis. An explicit forward time central space (FTCS) finite difference scheme is employed to obtain a numerical solution of these equations. Validation of the computations is achieved with another numerical method, namely the variational finite element method (FEM). The effects of various emerging rheological, nanoscale and thermofluid parameters on flow and heat/mass characteristics of blood are shown via several plots and discussed in detail. The circulating regions inside the flow field are also investigated through instantaneous patterns of streamlines. The work is relevant to nanopharmacological transport phenomena, a new and exciting area of modern medical fluid dynamics which integrates coupled diffusion, viscous flow and nanoscale drug delivery mechanisms.
Comparison of on-wafer multiline TRL and LRM+ calibrations for RF CMOS applications

This paper presents a quantitative comparison of the reference multiline TRL and LRM+ for a customized set of standards in a CMOS process using IBM's 0.13 mum technology. This comparison was undertaken for the first time and covered a frequency range from 1 to 110 GHz. It was demonstrated that the accuracy of the on-wafer multiline TRL and LRM+ calibration were in very good agreement. Both methods outperform the conventional off-wafer calibration with the DUT contact pad parasitics de-embedded.
The angiotensin-converting enzyme DD gene is associated with poor prognosis in Finnish sarcoidosis patients.

Angiotensin-converting enzyme (ACE) genotypes may reflect prognosis in sarcoidosis. They were determined in 59 Finnish sarcoidosis patients and 70 healthy control subjects. The prognosis of the sarcoidosis patients was determined after follow-up for 1, 2, 3, 5 and >5 yrs and classified as good (normal chest radiograph and lung function, no signs of extrapulmonary disease activity within 2 yrs from diagnosis), intermediate (neither good nor poor) or poor (persisting unstable pulmonary infiltrates, vital capacity and diffusing capacity of the lung for carbon monoxide <50% predicted and/or extrapulmonary disease activity after >5 yrs follow-up). The DD, ID and II genotypes were found in 31 and 27%, in 54 and 49%, and in 15 and 24% of patients and control subjects respectively. The odds ratio (DD+ID to II) was 1.45 (95% confidence interval 0.60-3.49). The D alelle was found more often in patients (58%) and in control subjects (51%) than the I allele but the difference was not statistically significant. Statistically significantly more patients with the DD genotype had a poor prognosis compared with patients with II homozygotes and ID heterozygotes. Among 11 patients with Löfgren's syndrome (bilateral hilar lymphadenopathy and erythema nodosum), four had the DD genotype. Three of these patients had a prognosis despite presenting a clinical picture usually associated with a good prognosis. The angiotensin-converting enzyme genotype may be a prognostic marker in sarcoidosis and larger studies are warranted to define its clinical utility.
A Hybrid Mock Circulatory System: Testing a Prototype Under Physiologic and Pathological Conditions

Hydraulic models of circulation are used to test mechanical heart assist devices and for research and training purposes. However, when compared with numerical models, they are rather expensive and often not sufficiently flexible or accurate. Flexibility and accuracy can be improved by merging numerical models with physical models, thus obtaining a hybrid model where numerical and physical sections are connected by an electrohydraulic interface.This concept is applied here to represent left ventricular function. The resulting hybrid model is inserted into the existing closed loop model of circulation. The hybrid model reproduces ventricular function by a variable elastance numerical model. Its interaction with the hydraulic sections is governed by measuring left atrial and systemic arterial pressures and computing the left ventricular output flow by the resolution of the corresponding equations. This signal is used to control a flow generator reproduced by a gear pump driven by a DC motor.Results obtained under different circulatory conditions demonstrate the behavior of the ventricular model on the pressure-volume plane and report the trend of the main hemodynamic variables.
Role of psychiatric comorbidity on cognitive function during and after the menopausal transition

While cognitive complaints are common during the menopausal transition, measurable cognitive decline occurs infrequently, often due to underlying psychiatric or neurological disease. To clarify the nature, etiology and evidence for cognitive and memory complaints during midlife, at the time of the menopausal transition, we have critically reviewed the evidence for impairments in memory and cognition associated with common comorbid psychiatric conditions, focusing on mood and anxiety disorders, attention-deficit disorder, prolonged stress and decreased quantity or quality of sleep. Both the evidence for a primary effect of menopause on cognitive function and contrarily the effect of cognition on the menopausal transition are examined. Impairment in specific aspects of executive function is explored. Evaluation and treatment strategies for the symptomatic menopausal woman distressed by changes in her day-to-day cognitive function with or without psychiatric comorbidity are presented.
Transparency and Economic Policy 1

We provide a multiperiod model of political competition in which voters imperfectly observe the electoral promises made to other voters. Imperfect observability generates an incentive for candidates to offer excessive transfers even if voters are homogeneous and taxation is distortionary. Government spending is larger than in a world of perfect observability. Transfers are partly financed through government debt, and the size of the debt is higher in less transparent political systems. The model provides an explanation of fiscal churning; it also predicts that groups whose transfers are less visible receive higher transfers, and that imperfect transparency of transfers may lead to underprovision of public goods. From the policy perspective, the main novelty of our analysis is a separate evaluation of the transparency of spending and the transparency of revenues. We show that the transparency of the political system does not unambigously improve efficiency: transparency of spending is beneficial, but transparency of revenues can be counterproductive because it endogenously leads to increased wasteful spending.