Miracle-dz/UniFAR-FTUs huggingface dataset:
Exploring how the management of ERP business benefits influences achieving them

Organizations nowadays require their project teams to develop a business case to get approval for Enterprise Resource Planning system selections and implementations. These business cases contain cost information, but also information on business benefits to be realized. Managing these expected benefits during both the selection process and the implementation phase is critical to achieve these benefits. This paper explores if and how these benefits were managed at Woonzorg Nederland, a Dutch housing association. It turned out that Woonzorg did not use the methods described in the literature and they also did not meet the goals which they expected. An important reason for this is that they did not share the expected benefits with the stakeholders. An approach using a conceptual benefit framework as described in [1] would probably have delivered better results.
A novel defect of peroxisome division due to a homozygous non-sense mutation in the PEX11β gene

Background Peroxisomes are organelles that proliferate continuously and play an indispensable role in human metabolism. Consequently, peroxisomal gene defects can cause multiple, often severe disorders, including the peroxisome biogenesis disorders. Currently, 13 different PEX proteins have been implicated in various stages of peroxisome assembly and protein import. Defects in any of these proteins result in a peroxisome biogenesis disorder. The authors present here a novel genetic defect specifically affecting the division of peroxisomes. Methods The authors have studied biochemical and microscopical peroxisomal parameters in cultured patient fibroblasts, sequenced candidate PEX genes and determined the consequence of the identified PEX11β gene defect on peroxisome biogenesis in patient fibroblasts at different temperatures. Results The patient presented with congenital cataracts, mild intellectual disability, progressive hearing loss, sensory nerve involvement, gastrointestinal problems and recurrent migraine-like episodes. Although microscopical investigations of patient fibroblasts indicated a clear defect in peroxisome division, all biochemical parameters commonly used for diagnosing peroxisomal disorders were normal. After excluding mutations in all PEX genes previously implicated in peroxisome biogenesis disorders, it was found that the defect was caused by a homozygous non-sense mutation in the PEX11β gene. The peroxisome division defect was exacerbated when the patient's fibroblasts were cultured at 40°C, which correlated with a marked decrease in the expression of PEX11γ. Conclusions This novel isolated defect in peroxisome division expands the clinical and genetic spectrum of peroxisomal disorders and indicates that peroxisomal defects exist, which cannot be diagnosed by standard laboratory investigations.
Applications of data selection via cross-entropy difference for real-world statistical machine translation

We broaden the application of data selection methods for domain adaptation to a larger number of languages, data, and decoders than shown in previous work, and explore comparable applications for both monolingual and bilingual crossentropy difference methods. We compare domain adapted systems against very large general-purpose systems for the same languages, and do so without a bias to a particular direction. We present results against real-world generalpurpose systems tuned on domain-specific data, which are substantially harder to beat than standard research baseline systems. We show better performance for nearly all domain adapted systems, despite the fact that the domainadapted systems are trained on a fraction of the content of their general domain counterparts. The high performance of these methods suggest applicability to a wide variety of contexts, particularly in scenarios where only small supplies of unambiguously domain-specific data are available, yet it is believed that additional similar data is included in larger heterogenous-content general-domain corpora.
Low Docosahexaenoic Acid, Dihomo-Gamma-Linolenic Acid, and Arachidonic Acid Levels Associated with Long-Term Mortality in Patients with Acute Decompensated Heart Failure in Different Nutritional Statuses

The clinical significance of polyunsaturated fatty acids (PUFAs) in acute decompensated heart failure (ADHF) in various nutritional statuses remains unclear. For this study, we enrolled 267 patients with ADHF admitted to the cardiac intensive care unit at Juntendo University hospital between April 2012 and March 2014. The association between long-term mortality, the geriatric nutritional risk index (GNRI), and levels of PUFAs, including eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), dihomo-gamma-linolenic acid (DGLA), and arachidonic acid (AA) was investigated. The median age was 73 (64–82) years, and mortality was 29% (62 patients). The event-free survival rates for all-cause death were higher in patients with high PUFA levels or GNRI than in those with low PUFA levels or GNRI (p < 0.05 for all). In particular, high DGLA in the low-GNRI group and high DHA or AA in the high-GNRI group were associated with high event-free survival (p < 0.05 for all). After accounting for confounding variables, DHA, DGLA, and AA, but not EPA, were associated with long-term mortality (p < 0.01 for all). This study concludes that in patients with ADHF, decreased levels of DHA, DGLA, and AA are independently associated with long-term mortality in the various nutritional statuses.
Metabolic mapping of the synergism between MK‐801 and SKF 38393 in rats with unilateral lesions of the dopaminergic nigrostriatal pathway

In rats with a unilateral lesion of the dopaminergic nigrostriatal pathway with 6‐hydroxydopamine, blockade of N‐methyl‐D‐aspartate receptors by MK‐801 strongly potentiated the turning behavior induced by D‐1 receptor stimulation. To determine the functional consequences of such positive interaction we measured the local rates of cerebral glucose utilization (ICMRglc) in lesioned rats treated with MK‐801 (0.1mg/kg) and the D‐1 agonist SKF 38393 (1.5 mg/kg), either alone or in combination. Treatment with each drug separately did not induce any substantial change in ICMRglc besides an increase in the metabolic activity of the dorsomedial caudate and entopeduncular nucleus (EP) of the lesioned side of MK‐801 treated rats, as compared to the same side of lesioned rats treated with vehicle. Combined administration of MK‐801 + SKF 38393 increased ICMRglc in the EP (+77%) and in the substantia nigra pars reticulata (SNr) (+30%) of the lesioned side as compared with the intact side, while it decreased ICMRglc in the lateral habenula (−26%). These changes were also significant when compared to the lesioned side of vehicle treated rats. The results suggest that while the caudate putamen might be the primary site of MK‐801 and SKF 38393 positive interaction, the EP and SNr are the striatal efferent areas where this positive interaction is expressed. © 1992 Wiley‐Liss, Inc.
Fast object localization and pose estimation in heavy clutter for robotic bin picking

We present a practical vision-based robotic bin-picking system that performs detection and three-dimensional pose estimation of objects in an unstructured bin using a novel camera design, picks up parts from the bin, and performs error detection and pose correction while the part is in the gripper. Two main innovations enable our system to achieve real-time robust and accurate operation. First, we use a multi-flash camera that extracts robust depth edges. Second, we introduce an efficient shape-matching algorithm called fast directional chamfer matching (FDCM), which is used to reliably detect objects and estimate their poses. FDCM improves the accuracy of chamfer matching by including edge orientation. It also achieves massive improvements in matching speed using line-segment approximations of edges, a three-dimensional distance transform, and directional integral images. We empirically show that these speedups, combined with the use of bounds in the spatial and hypothesis domains, give the algorithm sublinear computational complexity. We also apply our FDCM method to other applications in the context of deformable and articulated shape matching. In addition to significantly improving upon the accuracy of previous chamfer matching methods in all of the evaluated applications, FDCM is up to two orders of magnitude faster than the previous methods.
Cost-effectiveness of non-vitamin K antagonist oral anticoagulants for atrial fibrillation in Portugal

a Centro de Estudos de Medicina Baseada na Evidência, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal b Laboratório de Farmacologia Clínica e Terapêutica, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal c Unidade de Farmacologia Clínica, Instituto de Medicina Molecular, Lisboa, Portugal d Serviço de Cardiologia, Hospital Garcia de Orta, Almada, Portugal e Health & Value Department, Laboratórios Pfizer Lda, Porto Salvo, Portugal f Serviço de Medicina 2, Centro Hospitalar Lisboa Norte EPE, Portugal g Unidade de Farmacologia Clínica, Centro Hospitalar de Lisboa Central EPE, Portugal h Católica Lisbon School of Business and Economics, Lisboa, Portugal
Erythema multiforme-Like Drug Eruption with Oral Involvement after Intake of Leflunomide

Leflunomide is an antirheumatic agent of the type of a ‘disease-modifying antirheumatic drug’. In rare cases, severe skin reactions up to the extreme expression of toxic epidermal necrolysis have been observed. A female patient with rheumatoid arthritis had been treated with systemic steroids and methotrexate for 2 years. Five weeks prior to admission to our hospital methotrexate was replaced by leflunomide. Three weeks after initiation of leflunomide therapy a progressive generalized erythema with blistering formation occurred accompanied by increase of body temperature, chills and erosive lesions on the lips and oral mucosa. The palmar and plantar surfaces revealed edema, erythema and pulpitis with epidermolysis. On histologic examination necrotic keratinocytes and epidermal spongiosis were observed. After administration of high-dose prednisolone and topical treatment the patient recovered within 14 days. This is one of the few cases of severe drug reaction after intake of leflunomide. Therefore, the indication of this relatively new drug should be considered carefully.
Excluding Minors in Nonplanar Graphs of Girth at Least Five

A graph G is quasi 4-connected if it is simple, 3-connected, has at least five vertices, and for every partition (A, B, C) of V(G) either [mid ]C[mid ] [ges ] 4, or G has an edge with one end in A and the other end in B, or one of A,B has at most one vertex. We show that any quasi 4-connected nonplanar graph with minimum degree at least three and no cycle of length less than five has a minor isomorphic to P−10, the Petersen graph with one edge deleted. We deduce the following weakening of Tutte's Four Flow Conjecture: every 2-edge-connected graph with no minor isomorphic to P−10 has a nowhere-zero 4-flow. This extends a result of Kilakos and Shepherd who proved the same for 3-regular graphs.
Forecasting the Term Structure of Government Bond Yields

Despite powerful advances in yield curve modeling in the last twenty years, comparatively little attention has been paid to the key practical problem of forecasting the yield curve. In this paper we do so. We use neither the no-arbitrage approach, which focuses on accurately fitting the cross section of interest rates at any given time but neglects time-series dynamics, nor the equilibrium approach, which focuses on time-series dynamics (primarily those of the instantaneous rate) but pays comparatively little attention to fitting the entire cross section at any given time and has been shown to forecast poorly. Instead, we use variations on the Nelson-Siegel exponential components framework to model the entire yield curve, period-by-period, as a three dimensional parameter evolving dynamically. We show that the three time-varying parameters may be interpreted as factors corresponding to level, slope and curvature, and that they may be estimated with high efficiency. We propose and estimate autoregressive models for the factors, and we show that our models are consistent with a variety of stylized facts regarding the yield curve. We use our models to produce term-structure forecasts at both short and long horizons encouraging results. In particular, our forecasts appear much more accurate at long horizons than various standard benchmark forecasts.
Evaluation of a school-based intervention for adolescent sleep problems.

STUDY OBJECTIVES The present study investigated the effectiveness of a school-based intervention in increasing sleep knowledge and improving adolescent sleep problems. DESIGN A randomized, controlled trial using 2 groups (program class, classes-as-usual: [CAU]) assessed over 3 time points (pre-program, post-program, 6-week follow-up). PARTICIPANTS/SETTING Eighty-one students (mean age = 15.6 +/- 0.6 y; 33% male) from 2 schools in South Australia. Schools provided one class to participate in the sleep intervention program (N = 41) and a second class to act as a control class (N = 40). INTERVENTION Four 50-minute classes across a 4-week period. Classes consisted of educating adolescents on promoting and maintaining a healthy lifestyle based on a cognitive-behavior therapy framework. MEASUREMENTS AND RESULTS Data were collected pre-program, post-program, and at 6-week follow-up using an online questionnaire. Qualitative student and teacher data were collected at post-program. Baseline data indicated sleep problems were prevalent (53.1% insufficient sleep on school nights [< 8 h] and 77.8% discrepant school/weekend rise times [> 2 h]). These 2 criteria identified 36 adolescents with a delayed sleep timing (DST; Program, N = 21; CAU, N = 15). The program increased sleep knowledge (P = 0.001); however, analyses revealed no significant effects on target sleep variables as compared with the CAU class for the entire group (all P > 0.05). For DST adolescents, there was a significant interaction for reducing the discrepancy between school and weekend out of bed times (P = 0.002). There was no impact on other sleep parameters or depressed mood. CONCLUSIONS School-based sleep interventions for adolescents are a novel method for addressing a prevalent problem. Future programs should develop ways to motivate adolescents to change sleep practices.
ALTERATIONS IN THE CYTOLOGIC DETAIL OF INTESTINAL SMOOTH MUSCLE CELLS IN VARIOUS STAGES OF CONTRACTION

The fine structure of the longitudinal layer of the tunica muscularis of the mouse jejunum was studied in various stages of mechanically stimulated contraction. The relaxed cell is long and narrow with smooth cytoplasmic and nuclear contours. As contraction progresses, the cell becomes ellipsoid and its borders exhibit invaginations at the points of myofilamentous attachment to the plasma membrane and vesicle-containing projections of the intervening membrane. These changes are interpreted as representing the deforming forces applied by the myofilaments to the plasma membrane. The nucleus of the contracted cell is shortened and widened, with convolution of its limiting membranes. This alteration, as well as progressive changes in the alignment of cytoplasmic organelles, is thought to be due to forces exerted on the internal structure of the cell by the contractile elements. The myofilaments form a network of oriented bundles during contraction. Aggregates of filaments of two different diameters are noted. The two sizes of filaments intermingle only in small areas of increased density. These dense areas increase in length and number during contraction. A model of the functional organization of the cell is proposed.
Does String-Based Neural MT Learn Source Syntax?

We investigate whether a neural, encoder-decoder translation system learns syntactic information on the source side as a by-product of training. We propose two methods to detect whether the encoder has learned local and global source syntax. A ﬁne-grained analysis of the syntactic structure learned by the encoder reveals which kinds of syntax are learned and which are missing.
Population Pharmacokinetics and Dosing Optimization of Vancomycin in Children with Malignant Hematological Disease

ABSTRACT An increase in vancomycin dose has been proposed in adults with malignant hematological disease. As pediatric data are limited, our aim was to evaluate the population pharmacokinetics of vancomycin in order to define the appropriate dosing regimen in children with malignant hematological disease. Vancomycin concentrations were collected prospectively during therapeutic monitoring. Population pharmacokinetic analysis was performed using NONMEM software. Seventy children (age range, 0.3 to 17.7 years) were included. With the current recommended dosing regimen of 40 to 60 mg/kg/day, 53 children (76%) had subtherapeutic steady-state trough concentrations (Css/min of <10 mg/liter). A one-compartment model with first-order elimination was developed. Systematic covariate analysis identified that weight significantly influenced clearance (CL) and volume of distribution (V) with power functions of 0.677 for CL and 0.838 for V. Vancomycin CL also significantly increased with increases in creatinine clearance and seemed to be higher in children with malignant hematological disease than in the general pediatric population. The model was validated internally. Its predictive performance was further confirmed in an external validation by Bayesian estimation. A patient-tailored dosing regimen was developed based on the final pharmacokinetic model and showed that a higher proportion of patients reached the target Css/min than with the traditional mg/kg-basis dose (60% versus 49%) and that the risks associated with underdosing or overdosing were reduced. This is the first population pharmacokinetic study of vancomycin in children with malignant hematological disease. An optimized dosing regimen, taking into account patient weight, creatinine clearance, and susceptibility of the pathogens involved, could routinely be used to individualize vancomycin therapy in this vulnerable population.
[Management of type 2 diabetic patients in primary care in Spain].

BACKGROUND AND OBJECTIVE We assess the metabolic control, complications, quality of life related to health (QLRH) and the type and amount of medical resource consumption (MRC) in type 2 diabetic patients (2DMp) followed by primary care physicians (PCP) in Spain. PATIENTS AND METHOD We studied 628 2DMp divided in 4 cohorts: 1. Either newly diagnosed 2DMp who required pharmacological treatment or failed to non-pharmacological measures; 2. Patients pharmacologically treated for less than 1 year; 3. Patients with pharmacological treatment for more than 1 year; 4. Patients with impaired fasting glucose (control group). RESULTS Eighty percent of the subjects were overweight. At baseline, 27.9, 23.5 and 36.9% of patients from cohorts 1, 2 and 3, respectively, had HbA1C < 8%. After 6 months of follow-up, 14.6, 21.3 and 22.8% of patients from cohorts 1, 2 and 3, respectively, still had "bad control". At baseline, 38.0%, 21.2% and 20.7% of patients from cohorts 1, 2, and 3, respectively, had "bad lipid profile". After 6 months, 57.4%, 54.2% and 45.3% of cohorts 1, 2 and 3, respectively, still had plasma cLDL levels > 130 mg/dl. Complications were more frequent in cohort 3. During the 6-month period, MRC was higher among 2DMp than controls (p < 0.05) and higher among patients from cohort 3 (p < 0.05) compared with all the other patients. More diabetic than control patients and more patients from cohort 3 than patients from cohort 1 and 2 reported that their expected quality of life would be better without diabetes. CONCLUSIONS One out of four of diabetic patients studied had HbA1C and lipids higher than the limits suggested by guidelines. Type 2 diabetes is associated with higher MRC and worse QLRH. This situation is worse among long-term diabetic patients.
Stimuli-induced equilibrium point: A psychological field theory application in ramp merging systems

Based on the psychological field theory, the stimuli-induced equilibrium point (SIEP) model is formulated to characterize the interaction of a driver between two vehicles (leader and follower) in a three-vehicle platooning configuration. Considering the intensity of the stimuli that act upon a driver between these vehicles, the point at which the stimuli resultant becomes zero (i.e. the equilibrium point) is obtained. Consequently, the location of such a point within the leader-follower gap changes continuously according to the speed of the middle vehicle and the current traffic scenario. This methodology enables the systematic computation of speed and position references for automatic ramp merging systems. Such stimuli-induced equilibrium point has shown to improve the performance of existing merging control schemes while increasing safety conditions by providing enough reaction time for drivers to avoid an eventual collision.
Perfect colorings of the 12-cube that attain the bound on correlation immunity

We construct perfect $2$-colorings of the $12$-hypercube that attain our recent bound on the dimension of arbitrary correlation immune functions. We prove that such colorings with parameters $(x,12-x,4+x,8-x$) exist if $x=0$, $2$, $3$ and do not exist if $x=1$. This is a translation into English of the original paper by D. G. Fon-Der-Flaass, "Perfect colorings of the $12$-cube that attain the bound on correlation immunity", published in Russian in Siberian Electronic Mathematical Reports, vol. 4 (2007) 292-295.
THE EFFECTS OF ALTERED ARTERIAL TENSIONS OF CARBON DIOXIDE AND OXYGEN ON CEREBRAL BLOOD FLOW AND CEREBRAL OXYGEN CONSUMPTION OF NORMAL YOUNG MEN.

A method for measuring quantitatively the volume of cerebral blood flow in man by inhalation of nitrous oxide (1) found its first application in a study of the cerebral circulatory effects of low CO2 tension achieved by hyperventilation; of high CO2 tension, and of high and low 02 tensions obtained by inhalation of appropriate gas mixtures (2). Only the first part of this study, the effects of active and passive hyperventilation, has been published in detail (3). The purpose of the present paper is to present the remainder of these findings and to derive from them, together with those of the hyperventilation experiments, evidence bearing on the intrinsic control of the human cerebral circulation as revealed by quantitative measurements.
SnapMe if you can: privacy threats of other peoples' geo-tagged media and what we can do about it

The amount of media uploaded to the Web is still rapidly expanding. The ease-of-use of modern smartphones in combination with the proliferation of high-speed mobile networks facilitates a culture of spontaneous and often carefree sharing of user-generated content, especially photos and videos. An increasing number of modern devices are capable of embedding location information and other metadata into created content. However, currently there is not much user awareness of possible privacy consequences of such data. While in most cases users upload their own media consciously, the flood of media uploaded by others is so huge that it is almost impossible for users to stay aware of all media that might be relevant to them. Current social network services and photo-sharing sites mainly focus on the privacy of users' own media in terms of access control, but offer few possibilities to deal with privacy implications created by other users' actions. We conducted an online survey with 414 participants. The results show that users would like to get more information about media shared by others. Based on an analysis of prevalent sharing services like Flickr, Facebook, or Google+ and an analysis of metadata of three different sets of crawled photos, we discuss privacy implications and potentials of the emerging trend of (geo-)tagged media. Finally, we present a novel concept on how location information can actually help users to control the flood of potentially infringing or interesting media.