Miracle-dz/UniFAR-FTUs huggingface dataset:
Factors Associated With Enhanced Knowledge and Use of Secondary Transition Evidence-Based Practices

Students with disabilities lag behind peers without disabilities in most postsecondary outcome areas such as employment, postsecondary education, and independent living. Numerous initiatives aimed at supporting students as they transition from school to adult life have received attention over the last few decades. These initiatives include those that focus on preparing secondary special educators and transition personnel to be better equipped to facilitate these transitions. In this study, the authors examined the extent to which middle and high school educators (n = 280) and direct-service transition professionals (e.g., transition specialists, rehabilitation counselors; n = 203) reported level of knowledge and modes of access to this knowledge related to secondary transition evidence-based practices (EBPs). In addition, this study examined if there is a difference in educators and direct-service transition professionals in reported use of EBPs. Results indicate that few educators and direct-service transition professionals believe their professional development opportunities fully prepared them with the knowledge and skills to use secondary transition EBPs. Implications and future research directions are also presented.
Uplink CoMP under a Constrained Backhaul and Imperfect Channel Knowledge

Coordinated Multi-Point (CoMP) is known to be a key technology for next generation mobile communications systems, as it allows to overcome the burden of inter-cell interference. Especially in the uplink, it is likely that interference exploitation schemes will be used in the near future, as they can be used with legacy terminals and be based on operator-proprietary signal processing concepts, hence requiring no or little changes in standardization. Major drawbacks, however, are the extent of additional backhaul infrastructure needed, and the sensitivity to imperfect channel knowledge. This paper jointly addresses both issues in a new framework incorporating a multitude of proposed theoretical uplink CoMP concepts, which are then put into perspective with practical CoMP algorithms. This comprehensive analysis provides new insight into the potential value of different uplink CoMP concepts in next generation wireless communications systems, and reveals the subset of schemes that are most likely to be used in practice.
Expression of LGR5, an intestinal stem cell marker, during each stage of colorectal tumorigenesis.

BACKGROUND The Wnt target LGR5 has been recently identified as a murine intestinal stem cell marker. Its role during each stage of human colorectal tumorigenesis remains to be determined. PATIENTS AND METHODS LGR5 expression was investigated by immunohistochemical analysis in 17 low-grade and 13 high-grade intraepithelial neoplasias and 30 adenocarcinomas. RESULTS The number of LGR5-positive cells increased tumor, with clustering of the cells to form patches. An apparent difference in their distribution among the tumorigenesis stages was observed. LGR5 expression in luminal surface showed a negative association with the progressive grade of tumors, while that in lower crypt exhibited a positive association with grade. In adenocarcinomas, LGR5 expression in luminal surface was negatively associated with pStage, while it was almost invariably high in lower crypt during advanced pStage disease. CONCLUSION These results suggest that the shifts in the distribution of LGR5-positive cells towards the lower crypt play a role in the development and progression of colorectal cancer.
Clinical, radiographic and immunogenic effects after 1 year of tocilizumab-based treatment strategies in rheumatoid arthritis: the ACT-RAY study

Objective To assess the 1-year efficacy and safety of a regimen of tocilizumab plus methotrexate or placebo, which was augmented by a treat-to-target strategy from week 24. Methods ACT-RAY was a double-blind, 3-year trial. Adults with active rheumatoid arthritis despite methotrexate were randomised to add tocilizumab to ongoing methotrexate (add-on strategy) or to switch to tocilizumab plus placebo (switch strategy). Tocilizumab 8 mg/kg was administered every 4 weeks. Conventional open-label disease-modifying antirheumatic drugs (DMARDs) other than methotrexate were added at week 24 or later in patients with DAS28>3.2. Results 556 patients were randomised; 85% completed 52 weeks. The proportion of patients receiving open-label DMARDs was comparable in the add-on (29%) and switch (33%) arms. Overall, week 24 results were maintained or further improved at week 52 in both arms. Some endpoints favoured the add-on strategy. Mean changes in Genant-modified Sharp scores were small; more add-on (92.8%) than switch patients (86.1%) had no radiographic progression. At week 52, comparable numbers of patients had antidrug antibodies (ADAs; 1.5% and 2.2% of add-on and switch patients, respectively) and neutralising ADAs (0.7% and 1.8%). Rates of serious adverse events and serious infections per 100 patient-year (PY) were 11.3 and 4.5 in add-on and 16.8 and 5.5 in switch patients. In patients with normal baseline values, alanine aminotransferase elevations >3× upper limit of normal were observed in 11% of add-on and 3% of switch patients. Conclusions Despite a trend favouring the add-on strategy, these data suggest that both tocilizumab add-on and switch strategies led to meaningful clinical and radiographic responses.
Bilingualism on display: The framing of Welsh and English in Welsh public spaces

Abstract This article develops an interpretive perspective on public displays of bilingualism. Photographic data from contemporary Wales illustrate how public bilingual—Welsh and English—displays are organized in different frames, reflecting historically changing language-ideological priorities and more local symbolic markets. In institutionally driven displays, the Welsh language is framed as an autonomous code in parallel with English, displacing an earlier pattern of representing Welsh subordinated to English norms. In other frames Welsh is constructed as the only legitimate heartland language, or as an impenetrable cultural curiosity. In the most open and least institutionalized frame, Welsh is displayed as part of a culturally distinctive but syncretic cultural system. These framing contests dramatize deeper tensions that surface in attempts to revitalize minority languages under globalization. (Wales, Welsh, bilingualism, language display, language ideology, linguistic landscapes, metaculture)*
Mapping of a region of the paramyxovirus L protein required for the formation of a stable complex with the viral phosphoprotein P

The paramyxovirus large protein (L) and phosphoprotein (P) are both required for viral RNA-dependent RNA polymerase activity. Previous biochemical experiments have shown that L and P can form a complex when expressed from cDNA plasmids in vivo. In this report, L and P proteins of the paramyxovirus simian virus 5 (SV5) were coexpressed in HeLa T4 cells from cDNA plasmids, and L-P complexes were examined. To identify regions of the SV5 L protein that are required for L-P complex formation, 16 deletion mutants were constructed by mutagenesis of an SV5 L cDNA. Following coexpression of these L mutants with cDNA-derived P and radiolabeling with 35S-amino acids, cell lysates were analyzed for stable L-P complexes by a coimmunoprecipitation assay and by sedimentation on 5 to 20% glycerol gradients. Mutant forms of L containing deletions that removed as much as 1,008 residues from the C-terminal half of the full-length 2,255-residue L protein were detected in complexes with P by these two assays. In contrast, large deletions in the N-terminal half of L resulted in proteins that were defective in the formation of stable L-P complexes. Likewise, L mutants containing smaller deletions that individually removed N-terminal regions which are conserved among paramyxovirus and rhabdovirus L proteins (domain I, II, or III) were also defective in stable interactions with P. These results suggest that the N-terminal half of the L protein contains sequences important for stable L-P complex formation and that the C-terminal half of L is not directly involved in these interactions. SV5-infected HeLa T4 cells were pulse-labeled with 35S-amino acids, and cell extracts were examined by gradient sedimentation. Solubilized L protein was detected as an approximately 8 to 10S species, while the P protein was found as both a approximately 4S form (approximately 85%) and a species that cosedimented with L (approximately 15%). These data provide the first biochemical evidence in support of a simple domain structure for an L protein of the nonsegmented negative-sense RNA viruses. The results are discussed in terms of a structural model for the L protein and the interactions of L with the second viral polymerase subunit P.
Virulence studies on chromosomal α‐toxin and Θ‐toxin mutants constructed by allelic exchange provide genetic evidence for the essential role of α‐toxin in Clostridium perfringens‐mediated gas gangrene

The pathogenesis of clostridial myonecrosis, or gas gangrene, involves the growth of the anaerobic bacterium Clostridium perfringens in the infected tissues and the elaboration of numerous extracellular toxins and enzymes. The precise role of each of these toxins in tissue invasion and necrosis has not been determined. To enable genetic approaches to be used to study C. perfringens pathogenesis we developed an allelic exchange method which involved the transformation of C. perfringens cells with a suicide plasmid carrying a gene insertionally inactivated with an erythromycin‐resistance determinant. The frequency with which double reciprocal crossover events were observed was increased to a workable level by increasing the amount of homologous DNA located on either side of the inactivated gene. Allelic exchange was used to isolate mutations in the‘chromosomal pfoA gene, which encodes an oxygen‐labile haemolysin known as Θ‐toxin or perfringolysin O. and in the chromosomal pic gene, which encodes the α‐toxin or phospholipase C. The resultant mutants failed to produce detectable Θ‐toxin or α‐toxin activity, respectively, and could be complemented by recombinant plasmids that carried the respective wild‐type genes. The resultant strains were virulence tested in a mouse myonecrosis model. The results showed that the pic mutants had demonstrably reduced virulence and therefore provided definitive genetic evidence for the essential role of α‐toxin in gas gangrene or clostridial myonecrosis.
Using Class Imbalance Learning for Software Defect Prediction

To facilitate software testing, and save testing costs, a wide range of machine learning methods have been studied to predict defects in software modules. Unfortunately, the imbalanced nature of this type of data increases the learning difficulty of such a task. Class imbalance learning specializes in tackling classification problems with imbalanced distributions, which could be helpful for defect prediction, but has not been investigated in depth so far. In this paper, we study the issue of if and how class imbalance learning methods can benefit software defect prediction with the aim of finding better solutions. We investigate different types of class imbalance learning methods, including resampling techniques, threshold moving, and ensemble algorithms. Among those methods we studied, AdaBoost.NC shows the best overall performance in terms of the measures including balance, G-mean, and Area Under the Curve (AUC). To further improve the performance of the algorithm, and facilitate its use in software defect prediction, we propose a dynamic version of AdaBoost.NC, which adjusts its parameter automatically during training. Without the need to pre-define any parameters, it is shown to be more effective and efficient than the original AdaBoost.NC.
Attenuating Tumour Angiogenesis: A Preventive Role of Metformin against Breast Cancer

Metformin is one of the most widely prescribed antidiabetics for type 2 diabetes. A critical role of metformin against tumorigenesis has recently been implicated, although several studies also reported the lack of anticancer property of the antidiabetics. Given the controversies regarding the potential role of metformin against tumour progression, the effect of metformin against breast, cervical, and ovarian tumour cell lines was examined followed by in vivo assessment of metformin on tumour growth using xenograft breast cancer models. Significant inhibitory impact of metformin was observed in MCF-7, HeLa, and SKOV-3 cells, suggesting an antiproliferative property of metformin against breast, cervical, and ovarian tumour cells, respectively, with the breast tumour cells, MCF-7, being the most responsive. In vivo assessment was subsequently carried out, where mice with breast tumours were treated with metformin (20 mg/kg body weight) or sterile PBS solution for 15 consecutive days. No inhibition of breast tumour progression was detected. However, tumour necrosis was significantly increased in the metformin-treated group, accompanied by decreased capillary formation within the tumours. Thus, despite the lack of short-term benefit of metformin against tumour progression, a preventive role of metformin against breast cancer was implicated, which is at partially attributable to the attenuation of tumour angiogenesis.
Ambiversion as independent personality characteristic

OBJECTIVES: The EEG studies of the personality trait extraversion rarely commented as the intermediate subgroup or the ambiversion. Since the majority of human population falls precisely into the aforementioned intermediate category, it is important to study it more extensively. DESIGN: In this work we examined the influence of the individual personality characteristic ambiversion on sensorimotor and cognitive information processing by studying the auditory Event-Related Potentials (ERPs) of healthy volunteers in auditory mental and sensorimotor discrimination task conditions. The volunteers completed Eysenck Personality Questionnaire and were divided into introverts, ambiverts and extraverts. We compared the N1 and P3 amplitudes and latencies of ERP components between introvert, ambivert and extravert subgroups. For sensorimotor task series we calculated two response time parameters: the onset of response movement activity and the moment of maximal push force power. Mann-Whitney U-test was used for statistical analysis. RESULTS: The ambivert N1 amplitude was enhanced compared to the same ERP components of the extravert and the introvert subgroups. Our results revealed increase of P3 amplitudes for extravert subgroup in all passive, sensorimotor and mental task conditions. The ambivert showed higher P3 amplitude in comparison with introverts and extraverts predominantly in mental task series. Our data revealed activation differences in sensory and cognitive information processing related to extraversion and the ERP analysis confirmed that the personality characteristic ambiversion influences the N1 and P3 amplitudes of ERP components. CONCLUSION: This study confirms that ambiversion has its EEG reflection in the auditory ERP components and supports that ambiversion must not be neglected and should be researched further as independent personality characteristic compared to the relevant extremes.
The Confluence of Perceiving and Thinking in Consciousness Phenomenology

The processual relation of thinking and perceiving shall be examined from a historical perspective as well as on the basis of methodically conducted first-person observation. Historically, these two psychological aspects of human knowledge and corresponding philosophical positions have predominant alternating phases. At certain historical points, thinking and perceiving tend to converge, while in the interim phases they seem to diverge with an emphasis on one of them. While at the birth of modern science, for instance, these two forms of mental life were deeply interlinked, today they seem to be separated more than ever before – as a number of scientific crises have shown. Turning from the outer to the inner aspect of this issue, a phenomenological view becomes relevant. In terms of the consciousness phenomenology developed by Steiner (1861–1925) and Witzenmann’s (1905–1988) Structure Phenomenology, this article will show how a methodical integration of thinking and perceiving can be carried out on the basis of first-person observation. In the course of a skilled introspective or meditative self-observation the individual’s own mental micro-actions of separating and integrating come into view, jointly constituting what we usually call thinking and perceiving. Consequently, this approach includes a conceptual as well as a perceptual dimension the experimental confluence of which ties in with the methodological core principle of modern natural science. At the same time, making this principle explicit may open the way to a further development of human consciousness and its scientific delineation.
THE INFLUENCE OF LEARNING ENVIRONMENT AND ACADEMIC SELF-EFFICACY TOWARDS MATHEMATICS ACHIEVEMENT IN MASTERSKILL GLOBAL COLLEGE, MALAYSIA

This study aimed to examine the influence of two constructs – mathematics classroom learning environment and academic self-efficacy in mathematics – and their influence towards students’ mathematics achievement. For this purpose, a sample of 200 allied health college students was randomly selected from two campuses of Masterskill Global College. The questionnaire was a combination of two sets of inventories that had been modified to suit the purpose of study. They were the College and University Classroom Environment Inventory (CUCEI) and College Academic Self-Efficacy Scale (CASES). Two statistical procedures were utilized to examine the demographic and data analyses, which were descriptives and inferential statistics. The analyses reported respondents had high and positive perception on all constructs, and there were also significant difference in respondents’ perception based on campuses and mathematics achievement grades. Moreover, different construct significantly influence achievement in mathematics. Thus, for future research purposes this study could also be conducted in other allied health colleges.
Depression among Urban Adolescent Students of Some Selected Schools

To determine the factors related with depression among adolescent students, 165 male adolescent students aged 15 to 19 years from 2 urban schools and colleges were interviewed with semi-structured questionnaire during January to June 2012.The socio demographic details, smoking and depression histories were recorded. The Center for Epidemiologic Studies Depression Scale (CES-D) was used to measure the presence of depression. Smoking behavior was measured by a number of questions. Almost 49% respondents were depressed and 66% were smokers. Most of the respondents started smoking around the age of 14.3 years (54.1%) by the influence of their friends. Among the smokers 82.7% were depressed while 17.3% were depressed among nonsmokers (χ 2 =19.69, p=<0.001). Parental smoking affected 62.5% respondents for depression against 59.4% normal respondents whose parents were non smokers (χ 2 =7.52, p=.006). Domestic violence (χ 2 =18.4, p=<0.001), familial disharmony (χ 2 =18.44, p=0.001), stressful events in the life (χ 2 =21.38, p=<0.001), failure in love (χ 2 =12.6, p=0.002) also played roles for depression. After adjusting the non significant factors in logistic regression, familial disharmony (p<0.001), smoking (p=0.005) and stress (p=0.04) became significant factors associated with depression. Depression level was higher among adolescent smoker than nonsmoker students. Faridpur Med. Coll. J. 2014;9(2): 73-75
Communicating Risk: Wireless and Hardwired

Risk communication as a practical tool is becoming ever more popular. Risk communication consultancies are emerging worldwide to deal with issues ranging from reputational risk to crisis management. The theoretical and conceptual framework supporting such risk communication tools has developed comparatively slower. We still hear consultants talking about dialogue or participatory risk communication and management as if it were something new and innovative, despite the fact that it was described and discussed in an excellent National Research Council volume(1) more than 13 years ago and has been the topic of many subsequent thoughtful summaries and extensions. (2,3) To address this apparent gap, we instigated a special call for papers for the 2000 SRA meetings in Crystal City, Virginia. The best papers from this call appear in this issue of Risk Analysis. Although numerous fundamental risk communication questions remain unanswered, researchers have collected new empirical evidence on several crucial risk communication topics during the last decade. This evidence begins to close technological and methodological gaps, further our understanding of ethical tradeoffs, describe how cognitive and affective influences interact to produce risk behaviors, and integrate the fields of health, safety, and environmental risk communication.
What Do Parents of Children with Moderate and Severe Mental Disabilities Want

Twenty-five studies were reviewed which surveyed parents of children with moderate to severe men- tal disabilities to determine their wishes, needs, and for satisfaction with various services and aspects of seances provided to them and their children. Most of the studies were conducted between 1985 and 1994. They investigated a variety of issues including what parents wanted their children to learn, what type of school setting they desired, what type and degree of involvement the parents desired with the schools, their level of satisfaction with school, preschool, and community based services, and their needs and plan for their children as adults. Ways in which professionals can best address the wishes and needs of parents are presented in the conclusion of the paper.