Miracle-dz/UniFAR-FTUs huggingface dataset:
Hamming Embedding and Weak Geometry Consistency for Large Scale Image Search - extended version

This technical report presents and extends a recent paper we have proposed for large scale image search. State-of-the-art methods build on the bag-of- features image representation. We first analyze bag-of-features in the framework of approximate nearest neighbor search. This shows the sub-optimality of such a representation for matching descriptors and leads us to derive a more precise representation based on 1) Hamming embedding (HE) and 2) weak geometric consistency constraints (WGC). HE provides binary signatures that refine the matching based on visual words. WGC filters matching descriptors that are not consistent in terms of angle and scale. HE and WGC are integrated within an inverted file and are efficiently exploited for all images, even in the case of very large datasets. Experiments performed on a dataset of one million of images show a significant improvement due to the binary signature and the weak geometric consistency constraints, as well as their efficiency. Estimation of the full geometric transformation, i.e., a re-ranking step on a short list of images, is complementary to our weak geometric consistency constraints and allows to further improve the accuracy.
Price Destabilizing Speculation

It is sometimes asserted that rational speculative activity must result in more stable prices because speculators buy when prices are low and sell when they are high. This is incorrect. Speculators buy when the chances of price appreciation are high, selling when the chances are low. Speculative activity in an economy in which all agents are rational, have identical priors, and have access to identical information may destabilize prices, under any reasonable definition of destabilization. It takes extremely strong conditions to ensure that speculative activity (of the commodity storage variety) "stabilizes" price, even in a very weak sense.
Vinorelbine plus cisplatin vs. observation in resected non-small-cell lung cancer.

BACKGROUND We undertook to determine whether adjuvant vinorelbine plus cisplatin prolongs overall survival among patients with completely resected early-stage non-small-cell lung cancer. METHODS We randomly assigned patients with completely resected stage IB or stage II non-small-cell lung cancer to vinorelbine plus cisplatin or to observation. The primary end point was overall survival; principal secondary end points were recurrence-free survival and the toxicity and safety of the regimen. RESULTS A total of 482 patients underwent randomization to vinorelbine plus cisplatin (242 patients) or observation (240); 45 percent of the patients had pathological stage IB disease and 55 percent had stage II, and all had an Eastern Cooperative Oncology Group performance status score of 0 or 1. In both groups, the median age was 61 years, 65 percent were men, and 53 percent had adenocarcinomas. Chemotherapy caused neutropenia in 88 percent of patients (including grade 3 febrile neutropenia in 7 percent) and death from toxic effects in two patients (0.8 percent). Nonhematologic toxic effects of chemotherapy were fatigue (81 percent of patients), nausea (80 percent), anorexia (55 percent), vomiting (48 percent), neuropathy (48 percent), and constipation (47 percent), but severe (grade 3 or greater) toxic effects were uncommon (<10 percent). Overall survival was significantly prolonged in the chemotherapy group as compared with the observation group (94 vs. 73 months; hazard ratio for death, 0.69; P=0.04), as was relapse-free survival (not reached vs. 46.7 months; hazard ratio for recurrence, 0.60; P<0.001). Five-year survival rates were 69 percent and 54 percent, respectively (P=0.03). CONCLUSIONS Adjuvant vinorelbine plus cisplatin has an acceptable level of toxicity and prolongs disease-free and overall survival among patients with completely resected early-stage non-small-cell lung cancer.
Identification and analysis of internal promoters in Caenorhabditis elegans operons.

The current Caenorhabditis elegans genomic annotation has many genes organized in operons. Using directionally stitched promoterGFP methodology, we have conducted the largest survey to date on the regulatory regions of annotated C. elegans operons and identified 65, over 25% of those studied, with internal promoters. We have termed these operons "hybrid operons. " GFP expression patterns driven from internal promoters differ in tissue specificity from expression of operon promoters, and serial analysis of gene expression data reveals that there is a lack of expression correlation between genes in many hybrid operons. The average length of intergenic regions with putative promoter activity in hybrid operons is larger than previous estimates for operons as a whole. Genes with internal promoters are more commonly involved in gene duplications and have a significantly lower incidence of alternative splicing than genes without internal promoters, although we have observed almost all trans-splicing patterns in these two distinct groups. Finally, internal promoter constructs are able to rescue lethal knockout phenotypes, demonstrating their necessity in gene regulation and survival. Our work suggests that hybrid operons are common in the C. elegans genome and that internal promoters influence not only gene organization and expression but also operon evolution.
End-Devonian extinction and a bottleneck in the early evolution of modern jawed vertebrates

The Devonian marks a critical stage in the early evolution of vertebrates: It opens with an unprecedented diversity of fishes and closes with the earliest evidence of limbed tetrapods. However, the latter part of the Devonian has also been characterized as a period of global biotic crisis marked by two large extinction pulses: a “Big Five” mass extinction event at the Frasnian-Famennian stage boundary (374 Ma) and the less well-documented Hangenberg event some 15 million years later at the Devonian-Carboniferous boundary (359 Ma). Here, we report the results of a wide-ranging analysis of the impact of these events on early vertebrate evolution, which was obtained from a database of vertebrate occurrences sampling over 1,250 taxa from 66 localities spanning Givetian to Serpukhovian stages (391 to 318 Ma). We show that major vertebrate clades suffered acute and systematic effects centered on the Hangenberg extinction involving long-term losses of over 50% of diversity and the restructuring of vertebrate ecosystems worldwide. Marine and nonmarine faunas were equally affected, precluding the existence of environmental refugia. The subsequent recovery of previously diverse groups (including placoderms, sarcopterygian fish, and acanthodians) was minimal. Tetrapods, actinopterygians, and chondrichthyans, all scarce within the Devonian, undergo large diversification events in the aftermath of the extinction, dominating all subsequent faunas. The Hangenberg event represents a previously unrecognized bottleneck in the evolutionary history of vertebrates as a whole and a historical contingency that shaped the roots of modern biodiversity.
Critical Role for the Protons in FRTL-5 Thyroid Cells: Nuclear Sphingomyelinase Induced-Damage

Proliferating thyroid cells are more sensitive to UV-C radiations than quiescent cells. The effect is mediated by nuclear phosphatidylcholine and sphingomyelin metabolism. It was demonstrated that proton beams arrest cell growth and stimulate apoptosis but until now there have been no indications in the literature about their possible mechanism of action. Here we studied the effect of protons on FRTL-5 cells in culture. We showed that proton beams stimulate slightly nuclear neutral sphingomyelinase activity and inhibit nuclear sphingomyelin-synthase activity in quiescent cells whereas stimulate strongly nuclear neutral sphingomyelinase activity and do not change nuclear sphingomyelin-synthase activity in proliferating cells. The study of neutral sphingomyelinase/sphingomyelin-synthase ratio, a marker of functional state of the cells, indicated that proton beams induce FRTL-5 cells in a proapoptotic state if the cells are quiescent and in an initial apoptotic state if the cells are proliferating. The changes of cell life are accompanied by a decrease of nuclear sphingomyelin and increase of bax protein.
Prenatal Detection of Congenital Heart Diseases: One-Year Survey Performing a Screening Protocol in a Single Reference Center in Brazil

Objective. To describe the experience of a tertiary center in Brazil to which patients are referred whose fetuses are at increased risk for congenital heart diseases (CHDs). Methods. This was a cross-sectional observational study. The data was collected prospectively, during the year 2012, through a screening protocol of the fetal heart adapted from the International Society of Ultrasound in Obstetrics and Gynecology (ISUOG) guideline. We performed a fetal echocardiogram screening for all pregnant women who were referred to the fetal cardiology outpatient obstetrics clinic of a university hospital. The exams were classified as normal or abnormal. The cases considered abnormal were undergone to a postnatal echocardiogram. We categorized the abnormal fetal heart according to severity in “complex,” “significant,” “minor,” and “others. ” Results. We performed 271 fetal heart screening. The incidence of abnormal screenings was 9.96% (27 fetuses). The structural CHD when categorized due to severity showed 48.1% (n = 13) of “complex” cases, 18.5% (n = 5) “significant” cases, and 7.4% (n = 2) “minor” cases. The most common referral reason was by maternal causes (67%) followed by fetal causes (33%). The main referral indication was maternal metabolic disease (30%), but there was just one fetus with CHD in such cases (1.2%). CHDs were found in 19/29 fetuses with suspicion of some cardiac abnormality by obstetrician (65.5%). Conclusion. We observed a high rate of CHD in our population. We also found that there was higher incidence of complex cases.
Sexism, perceived discrimination, and system justification in the 2016 U.S. presidential election context

The 2016 U.S. presidential election provided a pertinent context for investigating novel influences on system-related beliefs. We examined Trump and Clinton supporters’ sexist attitudes toward women, perceptions of gender discrimination, and system justification before and after the election. Controlling for conservatism, we found that (a) Trump supporters reported more modern and hostile sexism than Clinton supporters; (b) male Trump supporters perceived greater gender discrimination toward men than male Clinton supporters, an effect mediated by sexist attitudes toward women; (c) female Trump supporters perceived less gender discrimination toward women than female Clinton supporters, an effect also mediated by sexist attitudes toward women; and (d) system justification increased among Trump supporters but decreased among Clinton supporters postelection. These results extend the existing literature on system-related beliefs by revealing the role of antifeminism and misogyny in shaping perceptions of gender discrimination and highlighting how political outcomes are associated with system threat versus reinforcement.
Parkinson’s Disease: From Pathogenesis to Pharmacogenomics

Parkinson’s disease (PD) is the second most important age-related neurodegenerative disorder in developed societies, after Alzheimer’s disease, with a prevalence ranging from 41 per 100,000 in the fourth decade of life to over 1900 per 100,000 in people over 80 years of age. As a movement disorder, the PD phenotype is characterized by rigidity, resting tremor, and bradykinesia. Parkinson’s disease -related neurodegeneration is likely to occur several decades before the onset of the motor symptoms. Potential risk factors include environmental toxins, drugs, pesticides, brain microtrauma, focal cerebrovascular damage, and genomic defects. Parkinson’s disease neuropathology is characterized by a selective loss of dopaminergic neurons in the substantia nigra pars compacta, with widespread involvement of other central nervous system (CNS) structures and peripheral tissues. Pathogenic mechanisms associated with genomic, epigenetic and environmental factors lead to conformational changes and deposits of key proteins due to abnormalities in the ubiquitin–proteasome system together with dysregulation of mitochondrial function and oxidative stress. Conventional pharmacological treatments for PD are dopamine precursors (levodopa, l-DOPA, l-3,4 dihidroxifenilalanina), and other symptomatic treatments including dopamine agonists (amantadine, apomorphine, bromocriptine, cabergoline, lisuride, pergolide, pramipexole, ropinirole, rotigotine), monoamine oxidase (MAO) inhibitors (selegiline, rasagiline), and catechol-O-methyltransferase (COMT) inhibitors (entacapone, tolcapone). The chronic administration of antiparkinsonian drugs currently induces the “wearing-off phenomenon”, with additional psychomotor and autonomic complications. In order to minimize these clinical complications, novel compounds have been developed. Novel drugs and bioproducts for the treatment of PD should address dopaminergic neuroprotection to reduce premature neurodegeneration in addition to enhancing dopaminergic neurotransmission. Since biochemical changes and therapeutic outcomes are highly dependent upon the genomic profiles of PD patients, personalized treatments should rely on pharmacogenetic procedures to optimize therapeutics.
Dirty-appearing white matter in multiple sclerosis: volumetric MR imaging and magnetization transfer ratio histogram analysis.

BACKGROUND AND PURPOSE In contrast to "normal-appearing" white matter (NAWM) in patients with multiple sclerosis (MS), there are subtle, abnormal and diffuse signal intensity changes often seen on T2-weighted MR images, which we have referred to as "dirty-appearing" white matter (DAWM). These areas of DAWM have slightly higher signal intensity than that of NAWM, but lower than that of lesion plaques. Our study was designed to determine the volumetric and magnetization transfer ratio (MTR) features of DAWM in patients with MS. METHODS Dual-echo fast spin-echo MR imaging and magnetization transfer imaging were performed in 22 patients with relapsing-remitting MS. Slightly hyperintense DAWM areas were manually outlined on the basis of T2-weighted imaging findings. The volume and MTR of DAWM were calculated and compared with the volume and MTR of NAWM and T2 lesion plaques. RESULTS The average volume of DAWM (18.3 mL) was greater than the average volume of T2 lesion plaques (11.0 mL, P =.04), and the mean MTR in DAWM (38.7%) differed significantly (P <.0001) from that in NAWM (40.7%) and plaques (33.3%). There was a modest negative correlation between either mean MTR (r = -0.60; P =.003) of DAWM or peak height (r = -0.50; P =.02) of DAWM with T2 lesion load. Neither DAWM volume nor total T2 abnormality (DAWM + plaques) volume correlates with the Expanded Disability Status Scale. CONCLUSION The results of this study indicate that MTR is able to differentiate DAWM from lesion plaques and NAWM and that DAWM might be a different pathologic process of the disease. The notion and quantification of these subtle imaging findings of DAWM areas may improve our understanding of certain stages of disease progression and disease burden in patients with relapsing-remitting MS.
Serum Interleukin-6, Insulin, and HOMA-IR in Male Individuals with Colorectal Adenoma

Purpose: It is widely acknowledged that chronic low-grade inflammation plays a key role in the development of obesity-related insulin resistance and type 2 diabetes. The level of circulating interleukin-6 (IL-6), one of the major proinflammatory adipokines, is correlated with obesity and insulin resistance, which are known to be risk factors for colorectal adenoma. We examined the association between the circulating level of IL-6 and the presence of colorectal adenoma. Experimental Design: In a total colonoscopy-based cross-sectional study conducted between January and December 2008, serum levels of IL-6 were measured in samples of venous blood obtained from 336 male participants attending health checkups (118 individuals with colorectal adenoma and 218 age-matched controls) after an overnight fast. Results: In the colorectal adenoma group, the median levels of serum IL-6 (1.24 vs. 1.04 pg/mL; P = 0.01), triglyceride, insulin, and homeostasis model assessment of insulin resistance (HOMA-IR) were to be significantly higher than those in the control group. When restricted to individuals with adenoma, levels of IL-6 were positively correlated with body mass index, insulin, and HOMA-IR. Multiple logistic analyses adjusted to include insulin or HOMA-IR showed that high levels of IL-6 were associated with the presence of colorectal adenoma. There was no significant interaction of IL-6 with HOMA-IR to modify this association. Conclusions: Our findings suggest that increased serum levels of IL-6 are positively associated with the presence of colorectal adenoma in men, independently of insulin and HOMA-IR. Clin Cancer Res; 18(2); 392–9. ©2011 AACR.
Formulaic language in English for Academic Purposes

Formulaic language has been a central concern in recent work on English for Academic Purposes. This chapter reviews the main motivations for EAP research in this area before critically discussing four issues which have been prominent in the literature: how analysis of formulaic language can help us understand the nature of academic language; how formulaic language relates to originality and criticality in academic work; how use of formulaic language influences the grades students receive; and how appropriate formulas for teaching can be identified.
Academic socialization, parental educational expectations, and academic self-efficacy among Latino adolescents

This study examined the direct association between parental educational expectations and adolescents' academic self-efficacy, as well as the moderating influence of parental academic socialization messages. Participants were 148 Latino parent-adolescent dyads with the majority of Mexican origin (80.4%). Most of the parent participants were mothers (85.8%). Adolescents were 13 (46%) or 14 (54%) years of age, and 53% identified as female. Adolescents reported their academic self-efficacy and perceptions of their parents’ educational expectations; parents reported on their academic socialization messages of shame/pressure and effort regarding academics. The results suggest that, after accounting for parents’ level of education and immigrant status, parental educational expectations were positively associated with adolescent academic self-efficacy. This association was stronger among adolescents whose parents reported transmitting fewer messages of shame/pressure and academic effort. These results point to the importance of nuances in the content and type of academic socialization messages within Latino families.
Morphology of Galactic Open Clusters

We analyzed the shapes of Galactic open clusters by the star-counting technique with the Two Micron All Sky Survey star catalog database. Morphological parameters such as the ellipticity and size have been derived via stellar density distribution, weighed by clustering probability. We find that most star clusters are elongated, even for the youngest star clusters of a few million years old, which are located near the Galactic disk. The shapes of young star clusters must reflect the conditions in the parental molecular clouds and during the cluster formation process. As an open cluster ages, stellar dynamics cause the inner part of the cluster to circularize, but the overall radius gets larger and the stellar density becomes sparser. We discuss how the internal relaxation process competes with Galactic external perturbation during cluster evolution.
Demographic Transition in Kerala Revisited

Many competing hypotheses about Keralas demographic transition have flourished and remained untested for long. This article undertakes a thorough review of demographic trends in Kerala by a careful scrutiny of evidence presented by various data sources. By employing a quantitative approach and using data for districts in and around Kerala the authors test some of the hypotheses put forward to explain the shift in levels of birth and death rates. The article also briefly discusses the implications of the current declines for the future of the Kerala economy and assesses the prospects for a similar change elsewhere in India. The results indicate that "female literacy emerges.as the single most important factor in explaining the demographic transition in Kerala. " (EXCERPT)
Online Shopping in Haiti: An Empirical Study of Students’ Shopping Perceptions and Consumer Behavior

II ACKNOWLEDGMENTS . III LIST OF TABLES . IV LIST OF APPENDICES . VII CHAPTER 1: INTRODUCTION . 1 1.1 Haiti . 2 1.2 Research Issue . 4 CHAPTER 2: LITERATURE REVIEW . 7 2.1 E-commerce, e-business, e-mobile, online shopping . 7 2.1.1 Definition and History . 7 2.1.2 E-commerce in Developing Countries . 9 2.1. 3 Online Shopping in Haiti . 13 2.2 Factors affecting online shopping . 14 2.2.1 Perceptions . 14 2.2.1.1 Perceived ease of use . 14 2.2.1.2 Perceived usefulness . 14 2.2.1.1 Benefits . 15 2.2.1.1 Security . 16 2.2.1.1 Risks . 16 2.2.2 Demographics . 18 2.2. 3 Trust . 27
Therapeutic Targeting of Anaplastic Lymphoma Kinase in Lung Cancer: A Paradigm for Precision Cancer Medicine

The anaplastic lymphoma kinase (ALK) receptor tyrosine kinase was initially discovered as a component of the fusion protein nucleophosmin (NPM)–ALK in anaplastic large-cell lymphoma (ALCL). Genomic alterations in ALK, including rearrangements, point mutations, and genomic amplification, have now been identified in several malignancies, including lymphoma, non–small cell lung cancer (NSCLC), neuroblastoma, inflammatory myofibroblastic tumor, and others. Importantly, ALK serves as a validated therapeutic target in these diseases. Several ALK tyrosine kinase inhibitors (TKI), including crizotinib, ceritinib, and alectinib, have been developed, and some of them have already been approved for clinical use. These ALK inhibitors have all shown remarkable clinical outcomes in ALK-rearranged NSCLC. Unfortunately, as is the case for other kinase inhibitors in clinical use, sensitive tumors inevitably relapse due to acquired resistance. This review focuses on the discovery, function, and therapeutic targeting of ALK, with a particular focus on ALK-rearranged NSCLC. Clin Cancer Res; 21(10); 2227–35. ©2015 AACR. See all articles in this CCR Focus section, “Progress in Lung Cancer. ”
Destigmatized Group Intervention on Promoting Hope of Recovery: A Quasi-Experiment Study

Objective: This research project aims to evaluate the effectiveness of a destigmatized group intervention in promoting hope of recovery for adults with mental illness. Methods: A quasi-experimental research method was adopted. In addition to treatment as usual (TAU), the treatment group (n = 36) participated in a 10-session destigmatized group intervention, which was based on cognitive behavioral therapy (CBT), while the control group (n = 42) received TAU. Standardized assessment tools were used for outcome assessment at the pretreatment and posttreatment periods. Results: The 2 × 2 repeated measures analysis of covariance demonstrated that participants who participated in the destigmatized group intervention experienced significantly fewer self-stigma and more hope of recovery. Additionally, multiple linear regression showed that the reduction of self-stigma predicted the promotion of hope of recovery. Conclusions: This study supports the effectiveness of the destigmatized group intervention, suggesting the importance of reducing self-stigma for facilitating recovery for adults with mental illness.