CONSORT-EHEALTH Checklist V1.6.2 Report

1b-i) Key features/functionalities/components of the intervention and comparator in the METHODS section of the ABSTRACT intervention group recieved Internet program Directlife, which was directed at increasing PA using monitoring and feedback by accelerometer and digital coaching' 1b-ii) Level of human involvement in the METHODS section of the ABSTRACT No specific providers were involved in the program (not relevant). 1b-iii) Open vs. closed, web-based (self-assessment) vs. face-to-face assessments in the METHODS section of the ABSTRACT " The primary outcome was relative increase in physical activity measured objectively using ankleand wrist-worn accelerometers. " 1b-iv) RESULTS section in abstract must contain use data Two-hundred and twenty-six participants (97%) completed the study. At the ankle, activity counts increased by 46% (standard error (SE) 7%) in the intervention group, compared to 12% (SE 3%) in the control group (pdifference<0.001). Measured at the wrist, activity counts increased by 11% (SE 3%) in the intervention group and 5% (SE 2%) in the control group (pdifference = 0.11). After processing of the data, this corresponded to an increase of 11 minutes in moderate-to-vigorous activity in the intervention group versus 0 minutes in the control group (pdifference = 0.001). Weight decreased significantly more in the intervention group compared to controls (-1.5 kg vs. -0.8 kg respectively, p=0.046), as did waist circumference (-2.3 cm vs. -1.3 cm respectively, p=0.036) and fat mass (-0.6% vs. 0.07% respectively, p =0.025). Furthermore, insulin and Hba1c levels were significantly more reduced in the intervention group compared to controls (both p < 0.05). 1b-v) CONCLUSIONS/DISCUSSION in abstract for negative trials " in inactive older adults, a 3-month web-based physical activity intervention was effective in increasing objectively measured daily physical activity and improving metabolic health" INTRODUCTION 2a-i) Problem and the type of system/solution " Intervention studies directed at increasing physical activity have been shown to be effective and may improve metabolism[8], also in older populations [9;10] . However, most of these interventions have used face-to-face communication, making them costly, time-consuming, thus hampering the potential of implementation as preventive programs at a larger scale. Novel technologies, such as Internet and e-mail, nowadays provide interactive ways to administer digital coaching and feedback on physical activity, and have potential for wide-scaled implementation. Moreover, it is unclear what the effect is of such web-based physical activity interventions on outcomes of metabolic health in old age" 2a-ii) Scientific background, rationale: What is known about the (type of) system " A recent meta-analysis on web-based physical activity intervention studies showed promising results in increasing daily physical activity[11]. Many of these, however, used either small study populations, included study populations under the age of 60, or did not measure physical activity objectively. Moreover, it is unclear what the effect is of such web-based physical activity interventions on outcomes of metabolic health in old age[12;13] . " METHODS 3a) CONSORT: Description of trial design (such as parallel, factorial) including allocation ratio " In this randomized controlled trial, we examined whether a 3-month web-assisted intervention directed at increasing daily physical activity was effective in 60-70 year old inactive individuals. The intervention comprised an Internet program aimed at increasing physical activity using monitoring and feedback by accelerometer and digital coaching. Furthermore, we studied the effect of this intervention on metabolic health including anthropometric measures and markers of glucose and lipid metabolism. " 3b) CONSORT: Important changes to methods after trial commencement (such as eligibility criteria), with reasons Not relevant, as this did not occur. We used a fully developed program which is available for consumers in the market. 3b-i) Bug fixes, Downtimes, Content Changes Not relevant, as this did not occur. 4a) CONSORT: Eligibility criteria for participants " 1) age between 60 and 70 years, 2) no history of diabetes or use of glucose lowering medication, 3) absence of disability impeding increase in physical activity, 4) possession and use of personal computer with Internet connection. " 4a-i) Computer / Internet literacy yes, see previous item 4a-ii) Open vs. closed, web-based vs. face-to-face assessments: "The study recruited participants aged 60 to 70 years from the region of Leiden, The Netherlands. The recruitment strategy included advertisement in local newspapers and press notification, directing participants motivated to increase physical activity to the study website where they completed an online questionnaire. " 4a-iii) Information giving during recruitment The newspaper advertisement and the patient information were issued in Dutch , and are not included in the manuscript. 4b) CONSORT: Settings and locations where the data were collected