Miracle-dz/UniFAR-FTUs huggingface dataset:
Vesical clear cell adenocarcinoma V. Nephrogenic adenoma: a diagnostic problem

Following the diagnosis of nephrogenic adenoma in a bladder lesion, which was later interpreted as early clear cell adenocarcinoma, the morphological and immunocytochemical features of these two lesions were reviewed to see if differences could be established for future diagnostic application. The architecture, extent, cell type, nuclear pleomorphism, presence of mitotic figures and glycogen content were recorded in 28 nephrogenic adenomas and the clear cell carcinoma. Similarly, the immunoreactivity for CAM 5.2, LP34, EMA and CEA of 10 nephrogenic adenomas and the clear cell carcinoma were compared. Proliferation rate in five nephrogenic adenomas and the carcinoma was assessed by antibody M1B1. Many of the features showed differences in degree or extent (clear cell change, nuclear pleomorphism, CAM 5.2 and CEA positivity). The only features distinct to clear cell carcinoma were the presence of solid islands, mitoses greater than 1/10 HPF (HPF area = 0.4 mm2) and M1B1 counts in excess of 29/200 in clear cell carcinoma (range 30/200‐83/200). Only the high M1B1 count was present in the first biopsy of the clear cell carcinoma.
Gesturing integrates top-down and bottom-up information: Joint effects of speakers’ expectations and addressees’ feedback

Abstract Speakers adapt their speech based on both prior expectations and incoming cues about their addressees’ informational needs (Kuhlen and Brennan 2010). Here, we investigate whether top-down information, such as speakers’ expectations about addressees’ attentiveness, and bottom-up cues, such as addressees’ feedback during conversation, also influence speakers’ gestures. In 39 dyads, addressees were either attentive when speakers told a joke or else distracted by a second task, while speakers expected addressees to be either attentive or distracted. Independently of adjustments in speech, both speakers’ expectations and addressees’ feedback shaped quantitative and qualitative aspects of gesturing. Speakers gestured more frequently when their prior expectations matched addressees’ actual behavior. Moreover, speakers with attentive addressees gestured more in the periphery of gesture space when they expected addressees to be attentive. These systematic adjustments in gesturing suggest that speakers flexibly adapt to their addressees by integrating bottom-up cues available during the interaction in light of attributions made from top-down expectations. That these sources of information lead to adjustments patterning similarly in speech and gesture informs theoretical frameworks of how different modalities are deployed and coordinated in dialogue.
Myxoid and Sarcomatoid Variants of Adrenocortical Carcinoma: Analysis of Rare Variants in Single Tertiary Care Center

The aim of this study is to describe rare variants of adrenocortical carcinoma (ACC) and to compare the prognosis with that of conventional ACC. We retrospectively reviewed 8 cases of myxoid variant, 1 sarcomatoid variant, and 14 cases of conventional ACC, who underwent surgical resection at the Asan Medical Center between 1996 and 2014. An analysis of the clinicopathological characteristics, including the Weiss score, Ki-67 labeling index, and reticulin framework assessment is presented. The mean age of patients with myxoid/sarcomatoid ACC was 45 years; 4 out of 9 patients were women. Mean primary tumor size was 12.9 cm and the mean weight was 702.4 g. Seven patients presented in an advanced stage (stage III/IV); 8 of these eventually developed distant metastasis. The mean Weiss score was 5.0 points and the Ki-67 labeling index was 15.6%. The extent of myxoid or sarcomatoid change on histological examination ranged from 10% to 75% of the examined tumor areas; reticulin framework alteration was observed in all cases. Four patients showed venous tumor thrombus. Most of the clinicopathological parameters were not significantly different from those of conventional ACC. However, myxoid or sarcomatoid variant (hazard ratios [HR], 3.59; 95% confidence intervals [CI], 1.13–11.38; P = 0.030) and Ki-67 labeling index (HR, 3.97; 95% CI, 1.18–13.41; P = 0.030) were independent predictors of overall survival after adjusting for age and sex. Myxoid or sarcomatoid histological features or an increased Ki-67 labeling index may be associated with poor overall survival in patients with ACC.
The low anterior cervical approach to the upper thoracic vertebrae: a decision by preoperative MR imaging.

PURPOSE Surgical approaches to the upper thoracic spine are fraught with many problems as they involve thoracotomy or sternotomy. We analyzed 102 midsagittal MRI scans to evaluate the level of the sternal notch in relation to the upper thoracic spine, so that if the tangential line through the upper part of the sternal notch passed below the level of the involved vertebra, we could surgically access the involved vertebra by the low anterior cervical approach, which is familiar to most spinal surgeons. MATERIALS AND METHODS Between January and June 2002, 102 consecutive mid-sagittal T2 weighted MRI scans were evaluated. The line as described above was then drawn on each MRI to assess the level of the involved vertebra. RESULTS In 68.7% of the cases, the level of the sternal notch corresponded to T2 and T3. This method of assessing accessibility was used in a patient with a fractured T3 that yielded excellent surgical exposure. It was found that routine use of saturation bands is not needed in upper thoracic spine pathology as it obscured the visualization of the sternal notch in 20% of the cases. CONCLUSION In patients with high thoracic fractures who require surgical decompression and stabilization, pre-operative MR scan and assessing the level of the vertebra in relation to the sternal notch can allow a low anterior cervical approach to be used thus decreasing the patient morbidity related to the surgical approach.
A systematic approach to investigate electronic and optical property of CuGaS2 using DFT

Present paper is a systematic analysis of electronic and optical properties of CuGaS2 ternary chalcopyrite semiconductor which having wide applications in area of optoelectronics. Complete knowledge of electronic structural behavior of these materials is a challenging part for researchers. All the calculations presented here are preformed using mBJ exchange correlation potential under density functional theory (DFT) framework and embodied in WIEN2K computer code. Our investigation indicates that CuGaS2 have direct band gap of 2.071eV and there absorption spectra shows good absorptive nature over wide solar spectrum range (0–5eV) which indicates suitability of this material in optoelectronic applications mostly in solar cell. All electronic and optical properties calculated in this paper poses good agreement with experimental result.
DeepArt: Learning Joint Representations of Visual Arts

This paper aims to generate a better representation of visual arts, which plays a key role in visual arts analysis works. Museums and galleries have a large number of artworks in the database, hiring art experts to do analysis works (e.g., classification, annotation) is time consuming and expensive and the analytic results are not stable because the results highly depend on the experiences of art experts. The problem of generating better representation of visual arts is of great interests to us because of its application potentials and interesting research challenges---both content information and each unique style information within one artwork should be summarized and learned when generating the representation. For example, by studying a vast number of artworks, art experts summary and enhance the knowledge of unique characteristics of each visual arts to do visual arts analytic works, it is non-trivial for computer. In this paper, we present a unified framework, called DeepArt, to learn joint representations that can simultaneously capture contents and style of visual arts. This framework learns unique characteristics of visual arts directly from a large-scale visual arts dataset, it is more flexible and accurate than traditional handcraft approaches. We also introduce Art500k, a large-scale visual arts dataset containing over 500,000 artworks, which are annotated with detailed labels of artist, art movement, genre, etc. Extensive empirical studies and evaluations are reported based on our framework and Art500k and all those reports demonstrate the superiority of our framework and usefulness of Art500k. A practical system for visual arts retrieval and annotation is implemented based on our framework and dataset. Code, data and system are publicly available at http://deepart.ece. ust.hk.
Clinical characteristics of children and adolescents with severe therapy-resistant asthma in Brazil

Abstract Objective: To describe the clinical characteristics, lung function, radiological findings, and the inflammatory cell profile in induced sputum in children and adolescents with severe therapy-resistant asthma (STRA) treated at a referral center in southern Brazil. Methods: We retrospectively analyzed children and adolescents (3-18 years of age) with uncontrolled STRA treated with high-dose inhaled corticosteroids and long-acting ß2 agonists. We prospectively collected data on disease control, lung function, skin test reactivity to allergens, the inflammatory cell profile in induced sputum, chest CT findings, and esophageal pH monitoring results. Results: We analyzed 21 patients (mean age, 9.2 ± 2.98 years). Of those, 18 (86%) were atopic. Most had uncontrolled asthma and near-normal baseline lung function. In 4 and 7, induced sputum was found to be eosinophilic and neutrophilic, respectively; the inflammatory cell profile in induced sputum having changed in 67% of those in whom induced sputum analysis was repeated. Of the 8 patients receiving treatment with omalizumab (an anti-IgE antibody), 7 (87.5%) showed significant improvement in quality of life, as well as significant reductions in the numbers of exacerbations and hospitalizations. Conclusions: Children with STRA present with near-normal lung function and a variable airway inflammatory pattern during clinical follow-up, showing a significant clinical response to omalizumab. In children, STRA differs from that seen in adults, further studies being required in order to gain a better understanding of the disease mechanisms.
Violation of Expectation: Neural Correlates Reflect Bases of Prediction

Setting perceptual expectations can be based on different sources of information that determine which functional networks will be involved in implementing preparatory top–down influences and dealing with situations in which expectations are violated. The goal of the present study was to investigate and directly compare brain activations triggered by violating expectations within two different task contexts. In the serial prediction task, participants monitored ordered perceptual sequences for predefined sequential deviants. In contrast, the target detection task entailed a presentation of stimuli which had to be monitored for predefined nonsequential deviants. Detection of sequential deviants triggered an increase of activity in premotor and cerebellar components of the “standard” sequencing network and activations in additional frontal areas initially not involved in sequencing. This pattern of activity reflects the detection of a mismatch between the expected and presented stimuli, updating of the underlying sequence representation (i.e., forward model), and elaboration of the violation. In contrast, target detection elicited activations in posterior temporal and parietal areas, reflecting an increase in perceptual processing evoked by the nonsequential deviant. The obtained results suggest that distinct functional networks involved in detecting deviants in different contexts reflect the origin and the nature of expectations being violated.
GMM Estimation of Empirical Growth Models

This Paper highlights a problem in using the first-differenced GMM panel data estimator to estimate cross-country growth regressions. When the time series are persistent, the first-differenced GMM estimator can be poorly behaved, since lagged levels of the series provide only weak instruments for subsequent first-differences. Revisiting the work of Caselli, Esquivel and Lefort (1996), we show that this problem may be serious in practice. We suggest using a more efficient GMM estimator that exploits stationarity restrictions and this approach is shown to give more reasonable results than first-differenced GMM in our estimation of an empirical growth model.
Auxin Signaling in Arabidopsis Leaf Vascular Development1

A number of observations have implicated auxin in the formation of vascular tissues in plant organs. These include vascular strand formation in response to local auxin application, the effects of impaired auxin transport on vascular patterns and suggestive phenotypes of Arabidopsis auxin response mutants. In this study, we have used molecular markers to visualize auxin response patterns in developing Arabidopsis leaves as well as Arabidopsis mutants and transgenic plants to trace pathways of auxin signal transduction controlling the expression of early procambial genes. We show that in young Arabidopsis leaf primordia, molecular auxin response patterns presage sites of procambial differentiation. This is the case not only in normal development but also upon experimental manipulation of auxin transport suggesting that local auxin signals are instrumental in patterning Arabidopsis leaf vasculature. We further found that the activity of the Arabidopsis gene MONOPTEROS, which is required for proper vascular differentiation, is also essential in a spectrum of auxin responses, which include the regulation of rapidly auxin-inducible AUX/IAA genes, and discovered the tissue-specific vascular expression profile of the class I homeodomain-leucine zipper gene, AtHB20. Interestingly, MONOPTEROSactivity is a limiting factor in the expression of AtHB8and AtHB20, two genes encoding transcriptional regulators expressed early in procambial development. Our observations connect general auxin signaling with early controls of vascular differentiation and suggest molecular mechanisms for auxin signaling in patterned cell differentiation.
Antibody to adhesion molecule LFA-1 enhances plasma neutralization of human immunodeficiency virus type 1

We have shown that a monoclonal antibody to the cell surface adhesion molecule LFA-1 (CD18/CD11a) enhances plasma neutralization of a laboratory isolate (HIVMN) and a primary isolate (HIV28R) of human immunodeficiency virus type 1. Human phytohemagglutinin blasts were infected with HIVMN or HIV28R in the presence of plasma pooled from HIV-positive individuals (AIDS plasma) or immunoglobulin G from AIDS plasma alone or combined with a monoclonal antibody (MAb) to LFA-1. While AIDS plasma alone at a dilution of 1:1,250 neutralized HIVMN and HIV28R infection by 15 and 0%, respectively, in the presence of a saturating concentration of the MAb to LFA-1 the plasma neutralized both viruses by more than 80% at this dilution. Immunoglobulin G purified from AIDS plasma, when used in combination with the MAb to LFA-1, showed the same synergistic effect in HIV neutralization as seen with the AIDS plasma and anti-LFA-1. The MAb against LFA-1 partially neutralized both viral isolates (45 to 55%) on its own. These results demonstrate significant synergy between the plasma and antibody against LFA-1 in the neutralization of HIV. The observations therefore suggest an important role for adhesion molecules in HIV infectivity and transmission. The results have implications for the recently observed host effect on HIV susceptibility to antibody neutralization.
Correction: Dual Energy CT Angiography of Peripheral Arterial Disease: Feasibility of Using Lower Contrast Medium Volume

One of the main drawbacks associated with Dual Energy Computed Tomography Angiography (DECTA) is the risk of developing contrast medium-induced nephropathy (CIN). The aim of the present study was firstly, to design an optimal CT imaging protocol by determining the feasibility of using a reduced contrast medium volume in peripheral arterial DECTA, and secondly, to compare the results with those obtained from using routine contrast medium volume.
Factors Influencing the Implementation of Anterior Cruciate Ligament Injury Prevention Strategies by Girls Soccer Coaches

Abstract Joy, EA, Taylor, JR, Novak, MA, Chen, M, Fink, BP, and Porucznik, CA. Factors influencing the implementation of anterior cruciate ligament injury prevention strategies by girls soccer coaches. J Strength Cond Res 27(8): 2263–2269, 2013—Women are 3 times more likely to injure their anterior cruciate ligament (ACL) while playing soccer than men. ACL injury prevention programs (IPPs) involving stretching and strengthening drills can reduce the incidence of ACL injury when incorporated into routine training. The rate of implementation among coaches is largely unknown. The purpose of this study was to determine the rate of implementation of ACL IPP, to identify factors that influence implementation, and to acquire information to assist in design dissemination and implementation strategies. Study subjects were coaches of woman soccer players aged 11–22 years in Utah (n = 756). Data were gathered using a Web-based survey followed by a qualitative study in which “best practice coaches”—coaches who met criteria for successful implementation of ACL IPP—were interviewed via telephone. A minority of survey respondents, 19.8% (27/136), have implemented ACL IPP. Factors associated with successful implementation include length of coaching experience and presence of additional support staff such as a strength and conditioning coach or athletic trainer. Best practice coaches (14/136) unanimously agreed on the following: (a) there are performance-enhancing benefits of ACL IPP, (b) education on ACL injury prevention should be required for licensure, and (c) dissemination and implementation will require soccer associations to enact policies that require IPPs. In conclusion, a minority of girls soccer coaches have implemented ACL IPP and those that have do so because they believe that prevention improves performance and that soccer organizations should enact policies requiring ACL injury prevention education and implementation. Efforts to implement ACL IPP should be driven by soccer organizations, emphasize performance-enhancing benefits, and engage additional coaching staff.
Bone density in type 1 gaucher disease

Skeletal involvement is a major source of complications in patients with Type 1 Gaucher disease. To investigate the bone density and potential usefulness of bone densitometry in Gaucher disease, dual‐energy X‐ray absorptiometry was used to measure the density of the lumbar spine, femoral neck, trochanter, and distal radius in 61 adult patients ranging in age from 22 to 77 years. The mean bone density at each site was significantly lower than expected for age and sex. The severity of the osteopenia correlated significantly with other clinical indicators of disease severity, including the N370S/84GG genotype, prior splenectomy, and hepatomegaly. The bone density measurements also correlated significantly with the severity of skeletal disease as assessed by skeletal radiography. Vertebral density remained an independent predictor of the severity of bone involvement even after controlling for age, sex, weight, genotype, splenectomy, and hepatomegaly. These findings suggest that bone density measurements provide a quantitative assessment of bone involvement in Type 1 Gaucher disease, which may permit serial, noninvasive monitoring of bone changes in this progressive disorder. (J Bone Miner Res 1996;11:1801–1807)
Management of personal information scraps

We introduce research on information scraps. short, self-contained personal notes that fall outside of traditional filing schemes. We report on a preliminary study of information scraps. nature and outline plans for the next phase of our user study. Based on ongoing study results, we describe our designs and prototypes for information scrap capture and access tools.
Diagnosis of medullary thyroid cancer

Medullary thyroid cancer (MTC) accounts for 5-10% of all thyroid cancers. The majority of medullary thyroid cancers are sporadic, but 25% of cases are inherited as a result of germline mutations in the RET proto-oncogene. In sporadic cases MTC presents as a thyroid nodule discovered at palpation or at thyroid ultrasonography, and is indistinguishable from thyroid nodules of different histology. Since effective treatment of MTC is only possible when the tumour is limited to the thyroid gland, early discovery has a decisive impact on how radical initial surgical treatment needs to be. Recent data suggest that in sporadic cases, early discovery of thyroid nodular disease is possible when screening serum calcitonin measurement, while screening for germline RET proto-oncogene mutations is fundamental in first degree relatives of patients with hereditary MTC.
ANCH: A New Clustering Algorithm for Wireless Sensor Networks

The adaptable and distributed nature of wireless sensor networks has made them popular in a broad range of applications. Clustering is a widely accepted approach for organising nodes in sensor networks to address the network congestion and energy efficiency concerns. In clustering, the number and uniform distribution of the cluster heads are crucial for the effectiveness of an algorithm. In this paper, we propose a new clustering algorithm for wireless sensor networks that reduces the networks energy consumption and significantly prolongs its lifetime. This is achieved by optimising the distribution of cluster heads across the network. The results of our extensive simulation study show considerable reduction in network energy consumption and therefore prolonging network lifetime.
Structure-function relationship and diagnostic value of macular ganglion cell complex measurement using Fourier-domain OCT in glaucoma.

PURPOSE To assess the relationship between visual function and macular ganglion cell complex (GCC) thickness measured by Fourier-domain optical coherence tomography (OCT) and to evaluate the diagnostic value of GCC thickness for detecting early, moderate, and severe glaucoma. METHODS Participants underwent reliable standard automated perimetry testing and OCT imaging with optic nerve head (ONH) mode and GCC mode within a single day. The relationship between structure and function was evaluated by comparing GCC thickness with mean deviation (MD) and visual field index (VFI), by regression analysis. The results were compared with those obtained for retinal nerve fiber layer (RNFL) thickness. The area under the receiver operating characteristic curve (AUC) was used to determine the relationship between disease severity and glaucomatous changes in RNFL and GCC parameters. RESULTS One hundred three normal control subjects and 138 patients with glaucoma were included in the present study. Compared with linear models, second-order polynomial models better described the relationships between GCC thickness and MD (P<0.001), and between GCC thickness and VFI (P<0.001). A GCC pattern parameter, global loss volume (GLV), had the highest AUC for detecting early glaucoma. The AUC of mean GCC thickness for early glaucoma was higher than that of mean RNFL; however, the difference was not significant (P=0.330). CONCLUSIONS A curvilinear function best described the relationship between VF sensitivity and GCC thickness. Macular GCC thickness and RNFL thickness showed similar diagnostic performance for detecting early, moderate, and severe glaucoma.