Miracle-dz/UniFAR-FTUs huggingface dataset:
Event attributes and the content of psychotic experiences in first-episode psychosis

Background. Previous psychosocial stress research, contemporary cognitive models, and new cognitive behavioural treatments for psychosis converge in suggesting that stressful events influence the content of psychotic experiences. In this paper we test whether the attributes of stressful events preceding the initial onset of psychosis are associated with core themes of the illness. Method. Forty-one people who had experienced a first episode of psychosis were assessed on the attributes of stressful events occurring in the year before onset, the themes (persecutory, depressive, and grandiose) associated with their delusions and the content of their auditory hallucinations. Results. Principal component analysis yielded four components accounting for 72% of the variance. As hypothesized, intrusive events were associated with the development of delusions with persecutory themes. Grandiose delusions were negatively associated with loss events. Depressive delusions appear to be associated with danger events rather than loss events. Conclusion. There are links between stressful event attributes and core psychotic themes at first-episode psychosis. This has implications for theoretical models of, and early psychological intervention for, psychosis.
Research on development characteristics and failure mechanism of land subsidence and ground fissure in Xi'an, monitored by using time-series SAR interferometry

Abstract The development characteristics of land subsidence of Xi'an by an advanced InSAR technique are investigated based on Envisat, Radarsat-2 and Sentinel-1 satellites, and it can be found that there still have been five typical land subsidence bowls with maximum subsidence rates beyond 40 mm/year in Xi'an. In 2012, the land subsidence took on slightly slowing down with a ground rebound area of up to 6.3 km2. But in 2003–2010, 2016 and 2017, there was more serious land subsidence and especially in 2017 the maximum velocity reached up to −137 mm/year. Yuhuazhai-Nanyaotou subsidence bowl as the greatest subsidence bowl, its area that rate was below 50 mm/year in 2017 was up to 10.64 km2. Moreover, these land subsidence bowls mainly concentrate upon tectonic depression area due to huge thickness clay soil and are spatially and temporally coincident with confined aquifer depression cones, suggesting that over-exploitation groundwater plays a decisive role for land subsidence. Ground fissure belts are generally controlled by normal faults in Xi'an, but asymmetry settlement of land surface can also give rise to the abnormal activities of ground fissure belts, which have caused serious threat or damage to building structures. In addition, it could also be found that surface uplift area in 2012 involves in both the tectonic depression area and loess ridge in terms of their same thickness sand layer.
Analysis and design of controllers for AQM routers supporting TCP flows

In active queue management (AQM), core routers signal transmission control protocol (TCP) sources with the objective of managing queue utilization and delay. It is essentially a feedback control problem. Based on a recently developed dynamic model of TCP congestion-avoidance mode, this paper does three things: 1) it relates key network parameters such as the number of TCP sessions, link capacity and round-trip time to the underlying feedback control problem; 2) it analyzes the present de facto AQM standard: random early detection (RED) and determines that REDs queue-averaging is not beneficial; and 3) it recommends alternative AQM schemes which amount to classical proportional and proportional-integral control. We illustrate our results using ns simulations and demonstrate the practical impact of proportional-integral control on managing queue utilization and delay.
Research Paper Series Globalisation and Labour Markets Programme Fragmentation, Globalization and Labour Markets the Centre Acknowledges Financial Support from the Leverhulme Trust under Programme Grant F114/bf Fragmentation, Globalization and Labor Markets

Acknowledgements This paper is a revised and simplified version of the one presented at the IEA conference "Globalization and Labour Markets", Nottingham 7 th-8 th July 2000. We thank Adrian Wood and Douglas Nelson for helpful comments. Abstract Fragmentation of the value-added-chain is modeled as the reaction of monopolistically competitive firms to the removal of barriers to trade and factor mobility in an integrated trading environment. Since fragmentation requires high-skilled labor, this form of globalization can induce labor market effects similar to those caused by skill-biased technical change. In the short run, it is likely that fragmentation will be accompanied by an increase in high and low-skilled service employment as well as in the skilled wage premia, as observed in OECD countries. These implications can be reversed, however, as new firms enter the market.
Number of calves born, number of calves weaned, and cumulative weaning weight as measures of lifetime production for Hereford cows.

Genetic parameters for lifetime production for cows with the opportunity to produce from 2 through 7 yr of age, as measured by the number of calves born (NB2, ., NB7), the number of calves weaned (NW2, ., NW7), and cumulative weaning weight (CW2, ., CW7), were estimated using data from 3,064 Hereford cows from a selection experiment with a control line (CTL) and three lines selected for weaning weight (WWL), yearling weight (YWL), and an index of yearling weight and muscle score (IXL). Weaning weights were adjusted to 200 d of age and for sex and age of dam. Estimates of heritability and genetic and environmental correlations were obtained by restricted maximum likelihood with bivariate animal models, with year of birth of the cow as a fixed effect and direct genetic and residual as random effects. Genetic trends were estimated by regressing means of estimated breeding values by year of birth and line on birth year. Estimates of heritability (SE) for opportunity groups of 2 to 7 yr of age ranged from 0.08 (0.03) to 0.16 (0.05) for NB; from 0.05 (0.02) to 0.16 (0.05) for NW; and from 0.06 (0.02) to 0.16 (0.05) for CW. Estimates of genetic correlations (SE) among NB traits ranged from 0.60 (0.14) to 1.00 (0.00), and estimates of environmental correlations (SE) ranged from 0.67 (0.02) to 0.99 (0.00). For NW, estimates of genetic and environmental correlations ranged from 0.98 (0.11) to 1.00 (0.00) and from 0.65 (0.02) to 0.99 (0.00), respectively. Estimates of genetic correlations (SE) among CW traits ranged from 0.94 (0.08) to 1.00 (0.00). Estimates of environmental correlations (SE) ranged from 0.66 (0.02) to 0.99 (0.00). Estimates of genetic correlations for NB2 with all definitions of NW ranged from 0.47 (0.18) to 0.71 (0.12), and with all definitions of CW ranged from 0.55 (0.16) to 0.80 (0.11). Estimates of genetic correlations between NW2 and all definitions for CW ranged from 0.95 (0.02) to 0.99 (0.06). Estimates of annual genetic (SE) change were negligible for NB2, NB6, NW2, and NW6 for all lines. Estimates of annual genetic (SE) change for CW2 were 0.85 (0.11), 0.79 (0.14), 0.51 (0.10), and 0.52 (0.18) kg/yr, and for CW6 were 5.01 (1.25), 2.64 (1.75), 3.67 (1.16), and 3.33 (2.37) kg/yr for WWL, YWL, IXL, and CTL, respectively. Selection for lifetime production as measured by NB, NW, or CW could be effective but would be relatively slow due to low estimates of heritability and to increased generation intervals.
Comparison between the Beck Depression Inventory and psychiatric evaluation of distress in patients on long-term sick leave due to chronic musculoskeletal pain

Background: Chronic musculoskeletal pain (CMP) is associated with psychological distress and long-term disability. Underlying diagnoses causing long-term sickness absence due to CMP have not been explored enough. In a somatic health care setting, it is important to identify mental health comorbidity to facilitate the selection of appropriate treatment. The objectives of this study were to compare the scores of depressed mood obtained on the Beck Depression Inventory (BDI) with the diagnosis of depression made by a psychiatrist, and to study the prevalence of undiagnosed mental health comorbidity in these patients. Methods and patients: 83 consecutive patients on sick leave (mean duration 21 months) due to CMP who had been referred by the Social Insurance Office to an orthopedist and a psychiatrist for assessment of the patient’s diagnoses and capacity to work. The mean age was 45 (23–61) years, 58% were women and 52% were immigrants. The accuracy of measurements was calculated using the Diagnostic Statistical Manual of Mental Disorders IV as the Gold standard. Results: Psychiatric illness was diagnosed in 87% of the patients. The diagnosis was depression in 56%, other psychiatric illnesses in 31%, whereas 13% were mentally healthy. Of all the patients, only 10% had a previous psychiatric diagnosis. The median value of the BDI score was 26 points in depressed patients, whereas it was 23 in patients with other psychiatric diagnoses. The sensitivity of the BDI to detect depression was 87.5%. We found good agreement between the BDI score and a diagnosis of depression. Conclusion: Undiagnosed psychiatric disorders were commonly seen in patients with CMP. The high sensitivity of the BDI scores enables the screening of mental health comorbidity in patients with a somatic dysfunction. The test is a useful tool for detecting distress in patients who are on long-term sick leave due to CMP and who need additional treatment.
Tidal Marshes across a Chesapeake Bay Subestuary Are Not Keeping up with Sea-Level Rise

Sea-level rise is a major factor in wetland loss worldwide, and in much of Chesapeake Bay (USA) the rate of sea-level rise is higher than the current global rate of 3.2 mm yr-1 due to regional subsidence. Marshes along estuarine salinity gradients differ in vegetation composition, productivity, decomposition pathways, and sediment dynamics, and may exhibit different responses to sea-level rise. Coastal marshes persist by building vertically at rates at or exceeding regional sea-level rise. In one of the first studies to examine elevation dynamics across an estuarine salinity gradient, we installed 15 surface elevation tables (SET) and accretion marker-horizon plots (MH) in tidal freshwater, oligohaline, and brackish marshes across a Chesapeake Bay subestuary. Over the course of four years, wetlands across the subestuary decreased 1.8 ± 2.7 mm yr-1 in elevation on average, at least 5 mm yr-1 below that needed to keep pace with global sea-level rise. Elevation change rates did not significantly differ among the marshes studied, and ranged from -9.8 ± 6.9 to 4.5 ± 4.3 mm yr-1. Surface accretion of deposited mineral and organic matter was uniformly high across the estuary (~9–15 mm yr-1), indicating that elevation loss was not due to lack of accretionary input. Position in the estuary and associated salinity regime were not related to elevation change or surface matter accretion. Previous studies have focused on surface elevation change in marshes of uniform salinity (e.g., salt marshes); however, our findings highlight the need for elevation studies in marshes of all salinity regimes and different geomorphic positions, and warn that brackish, oligohaline, and freshwater tidal wetlands may be at similarly high risk of submergence in some estuaries.
EVA: Large‐scale analysis of secondary structure prediction

EVA is a web‐based server that evaluates automatic structure prediction servers continuously and objectively. Since June 2000, EVA collected more than 20,000 secondary structure predictions. The EVA sets sufficed to conclude that the field of secondary structure prediction has advanced again. Accuracy increased substantially in the 1990s through using evolutionary information taken from the divergence of proteins in the same structural family. Recently, the evolutionary information resulting from improved searches and larger databases has again boosted prediction accuracy by more than 4% to its current height around 76% of all residues predicted correctly in one of the three states: helix, strand, or other. The best current methods solved most of the problems raised at earlier CASP meetings: All good methods now get segments right and perform well on strands. Is the recent increase in accuracy significant enough to make predictions even more useful? We believe the answer is affirmative. What is the limit of prediction accuracy? We shall see. All data are available through the EVA web site at {cubic.bioc. columbia.edu/eva/}. The raw data for the results presented are available at {eva}/sec/bup_common/2001_02_22/. Proteins 2001;Suppl 5:192–199. © 2002 Wiley‐Liss, Inc.
Comparison between young males and females with acute myocardial infarction.

OBJECTIVE To assess the differences between young males and females after acute myocardial infarction. METHODS We retrospectively studied 236 patients (54 females and 182 males) after acute myocardial infarction and during hospital stay assessed the following parameters: risk factors; the treatment used; the pattern of coronary artery obstruction; left ventricular ejection fraction; complications; and, using a logistic regression model, the factors related to the occurrence of reinfarction and death. RESULTS No significant difference was observed between the sexes in risk factors, pattern of coronary artery obstruction, and left ventricular function. The time interval between symptom onset and treatment was longer in females (p=0.03), who underwent thrombolysis (p=0.01) and angioplasty (p=0.03) less frequently than males did, but not myocardial revascularization. Female sex (OR = 5.98) and diabetes (OR = 14.52) were independent factors related to the occurrence of reinfarction and death. CONCLUSION Young males and females after acute myocardial infarction did not differ in coronary risk factors, and clinical and hemodynamic characteristics. Females had their treatment started later, and they underwent chemical thrombolysis and angioplasty less frequently than males did. Female sex and diabetes were related to the occurrence of reinfarction and death.
Relationship between Physical Examinations and Two-Dimensional Computed Tomographic Findings in Children with Intoeing Gait

Objective To evaluate the validity of physical examinations by assessment of correlation between physical examinations and CT measurements in children with intoeing gait and the causes of intoeing gait by age using CT measurements. Method Twenty-six children with intoeing gait participated in this study. The internal and external hip rotation, thigh-foot angle and transmalleolar angle were measured. In addition, femoral anteversion and tibial torsion of the subjects were assessed using a CT scan. The measurements of torsional angles were performed twice by two raters. The correlation coefficients between physical examinations and CT measurements were calculated using Pearson correlation. The data was analyzed statistically using SPSS v12.0. Results The correlation coefficients between physical examinations and CT measurements were not high. Before 5 years of age, intoeing gait was caused by femoral anteversion in 17.86%, tibial torsion in 32.29% and the combination of causes in 35.71% of cases. After 6 years of age, the contributions changed to 29.17%, 8.33% and 45.83%, respectively. Conclusion Before 5 years of age, the common cause of an intoeing gait was tibial torsion, whereas after 6 years of age it was femoral anteversion. Regardless of age, the most common cause of intoeing gait was a combination of causes. This study shows poor correlation between physical examinations and CT. Therefore, it is limiting to use physical examination only for evaluating the cause of intoeing gait in clinical practice.
Do you see what I see? Optical morphology and visual capability of ‘disco’ clams (Ctenoides ales)

ABSTRACT The ‘disco’ clam Ctenoides ales (Finlay, 1927) is a marine bivalve that has a unique, vivid flashing display that is a result of light scattering by silica nanospheres and rapid mantle movement. The eyes of C. ales were examined to determine their visual capabilities and whether the clams can see the flashing of conspecifics. Similar to the congener C. scaber, C. ales exhibits an off-response (shadow reflex) and an on-response (light reflex). In field observations, a shadow caused a significant increase in flash rate from a mean of 3.9 Hz to 4.7 Hz (P=0.0016). In laboratory trials, a looming stimulus, which increased light intensity, caused a significant increase in flash rate from a median of 1.8 Hz to 2.2 Hz (P=0.0001). Morphological analysis of the eyes of C. ales revealed coarsely-packed photoreceptors lacking sophisticated structure, resulting in visual resolution that is likely too low to detect the flashing of conspecifics. As the eyes of C. ales are incapable of perceiving conspecific flashing, it is likely that their vision is instead used to detect predators. Summary: ‘Disco’ clams are known for their vivid flashing displays. Their vision was examined to see if their display is visible to other disco clams as a signal.
Molecular Evolution of the RNA-Dependent RNA Polymerase and Capsid Genes of Human Norovirus Genotype GII.2 in Japan during 2004–2015

The RNA-dependent RNA polymerase (RdRp) and capsid (VP1) genes of 51 GII.2 human norovirus (HuNoV) strains collected during the period of 2004–2015 in Japan were analyzed. Full-length analyses of the genes were performed using next-generation sequencing. Based on the gene sequences, we constructed the time-scale evolutionary trees by Bayesian Markov chain Monte Carlo methods. Time-scale phylogenies showed that the RdRp and VP1 genes evolved uniquely and independently. Four genotypes of GII.2 (major types: GII.P2-GII.2 and GII.P16-GII.2) were detected. A common ancestor of the GII.2 VP1 gene existed until about 1956. The evolutionary rates of the genes were high (over 10−3 substitutions/site/year). Moreover, the VP1 gene evolution may depend on the RdRp gene. Based on these results, we hypothesized that transfer of the RdRp gene accelerated the VP1 gene evolution of HuNoV genotype GII.2. Consequently, recombination between ORF1 (polymerase) and ORF2 (capsid) might promote changes of GII.2 antigenicity.
A Review of Emerging Access Technologies for Individuals With Severe Motor Impairments

Research and development in the field of access technologies for individuals with severe motor impairments has accelerated over the past 10 years. Many emergent alternatives to conventional mechanical switches, such as infrared sensing, electromyography, oculography, and computer vision, have been investigated for those retaining some limited volitional motor ability. At the same time, electroencephalography, electrocorticography, intracortical recordings, and electro-dermal activity have been explored for those presenting as locked in. The relevant literature is scattered across many disciplines, obfuscating the strength of the clinical evidence in support of the different access technologies currently in development. This article systematically organizes the literature on the aforementioned access technologies, summarizing their underlying operational mechanisms while reviewing the clinical evidence reported between 1996 and 2006. Research evidence within this period is generally found to be at the case study or uncontrolled study level, with very modest sample sizes. Novel mechanical switches and electroencephalography-based access systems dominate the literature, whereas many other movement-based access modalities have emerged with promising early findings. Access methods for those without extant physical movement constitute a critical direction for future and ongoing research efforts.
Incorporating Relation Paths in Neural Relation Extraction

Distantly supervised relation extraction has been widely used to find novel relational facts from plain text. To predict the relation between a pair of two target entities, existing methods solely rely on those direct sentences containing both entities. In fact, there are also many sentences containing only one of the target entities, which also provide rich useful information but not yet employed by relation extraction. To address this issue, we build inference chains between two target entities via intermediate entities, and propose a path-based neural relation extraction model to encode the relational semantics from both direct sentences and inference chains. Experimental results on real-world datasets show that, our model can make full use of those sentences containing only one target entity, and achieves significant and consistent improvements on relation extraction as compared with strong baselines. The source code of this paper can be obtained from https://github.com/thunlp/PathNRE.
Xenogeneic immunization in mice using HER2 DNA delivered by an adenoviral vector

The protective efficacy of xenogeneic vaccination with DNA encoding the HER2 oncogene was evaluated in BALB/c mice transgenic for the transforming form of the neu oncogene, which spontaneously develops carcinomas in all mammary glands. Intramuscular injection of either plasmid DNA followed by electrical stimulation (pVIJ‐HER2 with ES) or an adenoviral vector (Ad5‐HER2), both expressing the HER2 oncogene, was tested. Immunization using pVIJ‐HER2 with ES elicited a cell‐mediated response that was much lower than that elicited by the immunization with Ad5‐HER2, as measured by the frequency of IFN‐γ‐secreting spleen cells. The dominant T‐cell epitope of the HER2 protein product (p185) in the BALB/c (H‐2d) genetic background was identified. While the T‐cell response elicited was only partially crossreactive with the corresponding rat epitopes because of sequence variations (89% similarity), a cytotoxic T‐lymphocyte activity against the rat immunodominant epitope was also evident. The Ad5‐HER2 vaccination induced also antibodies against p185, which crossreacted with the rat protein homolog. Both T‐ and B‐cell responses slowly declined with time. Vaccination with Ad5‐HER2 at 6 and 9 weeks of age delayed incidence and reduced multiplicity of tumors in neu transgenic mice.
Cerebral Palsy—Trends in Epidemiology and Recent Development in Prenatal Mechanisms of Disease, Treatment, and Prevention

Cerebral palsy (CP) is the most common motor disability in childhood. This syndrome is the manifestation of intrauterine pathologies, intrapartum complications, and the postnatal sequel, especially among preterm neonates. A double hit model theory is proposed suggesting that an intrauterine condition along with intrapartum or postnatal insult lead to the development of CP. Recent reports demonstrated that treatment during the process of preterm birth such as magnesium sulfate and postnatal modalities such as cooling may prevent or reduce the prevalence of this syndrome. Moreover, animal models demonstrated that postnatal treatment with anti-inflammatory drugs coupled with nanoparticles may affect the course of the disease in pups with neuroinflammation. This review will describe the changes in the epidemiology of this disease, the underlying prenatal mechanisms, and possible treatments that may reduce the prevalence of CP and alter the course of the disease.