Miracle-dz/UniFAR-FTUs huggingface dataset:
Delamination in reinforced concrete retrofitted with fiber reinforced plastics

The addition of fiber-reinforced plastic (FRP) laminates bonded to the tension face of concrete members is becoming an attractive solution to the rehabilitation and retrofit of damaged structural systems. Flexural strength is enhanced with this method but the failure behavior of the system can become more brittle, often involving delamination of the composite. This study investigates failure modes including delamination with the use of fiber reinforced plastics to rehabilitate various concrete structures. The focus is on delamination and its causes, specifically in the presence of existing cracks in the retrofitted concrete system. First, delamination processes in FRP retrofitted concrete sytems are studied through combined experimental and analytical procedures. The delamination process is observed to initiate in the concrete substrate with microcracks that coalesce into an unstable macrocrack at failure. This macroscopic behavior is modeled through a finite element procedure with a smeared crack approach, which is found to be limited in the ability to represent the stress intensity at the delamination tip. For this reason it is shown that interfacial fracture mechanics can be used to describe the bimaterial elasticity and complex stress intensity at the delamination tip and provide a criterion governing the propagation of delamination using energy methods. Then, peeling processes occurring at existing cracks in the retrofitted system are studied through fracture mechanics based experimental and analytical procedures. An experimental program involving specialized shear notch specimens demonstrates that the location of the notch and laminate development length are influential on the shear crack peeling process. A finite element procedure is used to evaluate the crack driving forces applied at the shear notch crack mouth, and the fracture analysis is extended to evaluate initiation of peeling at the shear notch scenario. Finally, delamination failures in FRP retrofitted reinforced concrete beams representing "real-life" retrofit scenarios are investigated. An experimental and analytical program is conducted to investigate influences on the failure processes. The application of the fracture based peeling analysis to a quantitative design procedure is investigated, and a computational design aid to assist the iterative design procedure is developed. Thesis Supervisor: Oral Buyukozturk Title: Professor of Civil and Environmental Engineering
Intravital Multiphoton Microscopy with Fluorescent Bile Salts in Rats as an In Vivo Biomarker for Hepatobiliary Transport Inhibition

The bile salt export pump (BSEP) is expressed at the canalicular domain of hepatocytes, where it mediates the elimination of monovalent bile salts into the bile. Inhibition of BSEP is considered a susceptibility factor for drug-induced liver injury that often goes undetected during nonclinical testing. Although in vitro assays exist for screening BSEP inhibition, a reliable and specific method for confirming Bsep inhibition in vivo would be a valuable follow up to a BSEP screening strategy, helping to put a translatable context around in vitro inhibition data, incorporating processes such as metabolism, protein binding, and other exposure properties that are lacking in most in vitro BSEP models. Here, we describe studies in which methods of quantitative intravital microscopy were used to identify dose-dependent effects of two known BSEP/Bsep inhibitors, 2-[4-[4-(butylcarbamoyl)-2-[(2,4-dichlorophenyl)sulfonylamino]phenoxy]-3-methoxyphenyl]acetic acid (AMG-009) and bosentan, on hepatocellular transport of the fluorescent bile salts cholylglycyl amidofluorescein and cholyl-lysyl-fluorescein in rats. Results of these studies demonstrate that the intravital microscopy approach is capable of detecting Bsep inhibition at drug doses well below those found to increase serum bile acid levels, and also indicate that basolateral efflux transporters play a significant role in preventing cytosolic accumulation of bile acids under conditions of Bsep inhibition in rats. Studies of this kind can both improve our understanding of exposures needed to inhibit Bsep in vivo and provide unique insights into drug effects in ways that can improve our ability interpret animal studies for the prediction of human drug hepatotoxicity.
Maintaining the feelings of others in working memory is associated with activation of the left anterior insula and left frontal-parietal control network

Abstract The maintenance of social/emotional information in working memory (SWM/EWM) has recently been the topic of multiple neuroimaging studies. However, some studies find that SWM/EWM involves a medial frontal-parietal network while others instead find lateral frontal-parietal activations similar to studies of verbal and visuospatial WM. In this study, we asked 26 healthy volunteers to complete an EWM task designed to examine whether different cognitive strategies— maintaining emotional images, words, or feelings— might account for these discrepant results. We also examined whether differences in EWM performance were related to general intelligence (IQ), emotional intelligence (EI), and emotional awareness (EA). We found that maintaining emotional feelings, even when accounting for neural activation attributable to maintaining emotional images/words, still activated a left lateral frontal-parietal network (including the anterior insula and posterior dorsomedial frontal cortex). We also found that individual differences in the ability to maintain feelings were positively associated with IQ and EA, but not with EI. These results suggest that maintaining the feelings of others (at least when perceived exteroceptively) involves similar frontal-parietal control networks to exteroceptive WM, and that it is similarly linked to IQ, but that it also may be an important component of EA.
Bounds on the Menu-Size of Approximately Optimal Auctions via Optimal-Transport Duality

The question of the minimum menu-size for approximate (i.e., up-to-$\varepsilon$) Bayesian revenue maximization when selling two goods to an additive risk-neutral quasilinear buyer was introduced by Hart and Nisan (2013), who give an upper bound of $O(\frac{1}{\varepsilon^4})$ for this problem. Using the optimal-transport duality framework of Daskalakis et al. (2013, 2015), we derive the first lower bound for this problem - of $\Omega(\frac{1}{\sqrt[4]{\varepsilon}})$, even when the values for the two goods are drawn i.i. d. from "nice" distributions, establishing how to reason about approximately optimal mechanisms via this duality framework. This bound implies, for any fixed number of goods, a tight bound of $\Theta(\log\frac{1}{\varepsilon})$ on the minimum deterministic communication complexity guaranteed to suffice for running some approximately revenue-maximizing mechanism, thereby completely resolving this problem. As a secondary result, we show that under standard economic assumptions on distributions, the above upper bound of Hart and Nisan (2013) can be strengthened to $O(\frac{1}{\varepsilon^2})$.
Antenatal dexamethasone before asphyxia promotes cystic neural injury in preterm fetal sheep by inducing hyperglycemia

Antenatal glucocorticoid therapy significantly improves the short-term systemic outcomes of prematurely born infants, but there is limited information available on their impact on neurodevelopmental outcomes in at-risk preterm babies exposed to perinatal asphyxia. Preterm fetal sheep (0.7 of gestation) were exposed to a maternal injection of 12 mg dexamethasone or saline followed 4 h later by asphyxia induced by 25 min of complete umbilical cord occlusion. In a subsequent study, fetuses received titrated glucose infusions followed 4 h later by asphyxia to examine the hypothesis that hyperglycemia mediated the effects of dexamethasone. Post-mortems were performed 7 days after asphyxia for cerebral histology. Maternal dexamethasone before asphyxia was associated with severe, cystic brain injury compared to diffuse injury after saline injection, with increased numbers of seizures, worse recovery of brain activity, and increased arterial glucose levels before, during, and after asphyxia. Glucose infusions before asphyxia replicated these adverse outcomes, with a strong correlation between greater increases in glucose before asphyxia and greater neural injury. These findings strongly suggest that dexamethasone exposure and hyperglycemia can transform diffuse injury into cystic brain injury after asphyxia in preterm fetal sheep.
At What Latency Does the Phase of Brain Oscillations Influence Perception?

Abstract Recent evidence has shown a rhythmic modulation of perception: prestimulus ongoing electroencephalography (EEG) phase in the θ (4–8 Hz) and α (8–13 Hz) bands has been directly linked with fluctuations in target detection. In fact, the ongoing EEG phase directly reflects cortical excitability: it acts as a gating mechanism for information flow at the neuronal level. Consequently, the key phase modulating perception should be the one present in the brain when the stimulus is actually being processed. Most previous studies, however, reported phase modulation peaking 100 ms or more before target onset. To explain this discrepancy, we first use simulations showing that contamination of spontaneous oscillatory signals by target-evoked ERP and signal filtering (e.g., wavelet) can result in an apparent shift of the peak phase modulation towards earlier latencies, potentially reaching the prestimulus period. We then present a paradigm based on linear systems analysis which can uncover the true latency at which ongoing EEG phase influences perception. After measuring the impulse response function, we use it to reconstruct (rather than record) the brain activity of human observers during white noise sequences. We can then present targets in those sequences, and reliably estimate EEG phase around these targets without any influence of the target-evoked response. We find that in these reconstructed signals, the important phase for perception is that of fronto-occipital ∼6 Hz background oscillations at about 75 ms after target onset. These results confirm the causal influence of phase on perception at the time the stimulus is effectively processed in the brain.
Symplastic communication spatially directs local auxin biosynthesis to maintain root stem cell niche in Arabidopsis

Significance The whole-cell file lineages of plant roots are derived from a small group of initials that surround a functional and structural center, called the quiescent center (QC). It’s known that the QC maintains the directly abutting stem cells undifferentiated, but the mechanism for the maintenance is not entirely clear. Using a system that effectively blocks plasmodesmata in the QC, we show that QC-derived signals symplastically instruct the status of surrounding stem cells. Via directing local auxin biosynthesis, cell-to-cell communication between the QC and neighboring cells provides positional information for stem cell maintenance. Our results reveal a tight link between symplastic communication and auxin-dependent stem cell maintenance. Stem cells serve as the source of new cells for plant development. A group of stem cells form a stem cell niche (SCN) at the root tip and in the center of the SCN are slowly dividing cells called the quiescent center (QC). QC is thought to function as a signaling hub that inhibits differentiation of surrounding stem cells. Although it has been generally assumed that cell-to-cell communication provides positional information for QC and SCN maintenance, the tools for testing this hypothesis have long been lacking. Here we exploit a system that effectively blocks plasmodesmata (PD)-mediated signaling to explore how cell-to-cell communication functions in the SCN. We showed that the symplastic signaling between the QC and adjacent cells directs the formation of local auxin maxima and establishment of AP2-domain transcription factors, PLETHORA gradients. Interestingly we found symplastic signaling is essential for local auxin biosynthesis, which acts together with auxin polar transport to provide the guidance for local auxin enrichment. Therefore, we demonstrate the crucial role of cell-to-cell communication in the SCN maintenance and further uncover a mechanism by which symplastic signaling initiates and reinforces the positional information during stem cell maintenance via auxin regulation.
Why did severe feather pecking and cannibalism outbreaks occur? An unintended case study while investigating the effects of forage and stress on pullets during rearing

&NA; This 2 × 2 factorial experiment aimed to investigate the effects of stimulating foraging behavior from wk 6 and imposed stress at wk 16 on the development of severe feather pecking (SFP) in chickens reared for free‐range egg production. Non‐beak‐trimmed ISA Brown chicks were purchased at one day old and floor‐reared on wood shavings. From wk 6, straw was provided daily in dispensers (Forage vs. No forage) to stimulate foraging. At wk 15, there were 16 pens of 50 pullets. “Stressors” were applied to half the pens in wk 16 via combined transport, relocation, and mixing (TRM) of pullets, simulating activities around transfer from the rearing to egg‐laying farm (TRM vs. Not TRM). Range access was permitted from wk 21. Behavior, plumage damage (PD), growth, egg production, feed use, injuries, and mortalities were recorded, along with litter moisture and pH. In wk 26, an SFP outbreak commenced. By wk 34, PD was worse in south‐ than north‐aspect pens (P < 0.001). Further, PD was more affected by side of the shed than the experimental treatments. In wk 30, an outbreak of injurious pecking (IP) commenced in the 4 TRM‐treatment pens on the south side, with IP deaths almost 3 times more common in the Forage+TRM than No forage+TRM treatment. We suggest factors associated with a 13‐day rainfall event that occurred in late winter predisposed the flock to SFP. While multiple factors such as winter cold, muddy ranges, damp floor litter with elevated pH, among others coincided, hens were clearly more impacted in south‐ than north‐aspect pens. Once initiated, SFP possibly spread via social learning, and by wk 40, ˜98% of hens had PD. Interestingly, the IP outbreak was related to a combination of factors (stressors? ), such as being housed in colder, damper south‐aspect pens (note: southern hemisphere), having added Forage, and TRM. These unexpected relationships could help direct future research to identify the specific factors involved in the causation of SFP and IP/cannibalism outbreaks.
Cued memory decline in biomarker-defined preclinical Alzheimer disease

Objective: To determine whether a decline in cued recall is observable in the preclinical stage of Alzheimer disease (AD) in clinically normal older adults with elevated β-amyloid (Aβ) burden on PET imaging. Methods: Clinically normal older adults underwent baseline neuroimaging (PET to assess Aβ+/− status and MRI) and annual neuropsychological testing. Cox proportional hazards models were used to assess the relative risk of cued memory decline (drop of 1, 2, 3, or 4 points on the total score of the Free and Cued Selective Reminding Test) in relation to neuroimaging measures, functional status, age, sex, and education. Results: A total of 276 older adults (Clinical Dementia Rating = 0, mean Mini-Mental State Examination score = 29 ± 1.06) were followed up for a mean of 3.6 ± 1.2 years. Despite the infrequency of cued memory decline (only 19% of participants scored ≤46/48 in total recall by year 3), Aβ+ participants were 3.55 times (95% confidence interval = 1.77–7.12) more likely to exhibit decline in total recall (≤46/48) compared with their Aβ− peers. Furthermore, Aβ+ participants who scored ≤46/48 had smaller hippocampal volumes (t = 3.37, p = 0.001) and evidence of early functional decline, i.e., greater risk of progression to global Clinical Dementia Rating of 0.5 (χ2 = 14.30, p < 0.001), compared with their Aβ+ peers with intact total recall. Conclusions: Cued memory decline in healthy older adults may be particularly indicative of Aβ-related decline during the preclinical stage of AD and useful for identifying Aβ+ clinically normal individuals at greatest risk of short-term clinical progression.
A phase II trial of riluzole, an antagonist of metabotropic glutamate receptor 1 (GRM1) signaling, in patients with advanced melanoma

Studies demonstrate that GRM, expressed by >60% of human melanomas, may be a therapeutic target. We performed a phase II trial of 100 mg PO bid of riluzole, an inhibitor of GRM1 signaling, in patients with advanced melanoma with the primary endpoint of response rate. Thirteen patients with GRM1‐positive tumors were enrolled. No objective responses were observed, and accrual was stopped. Stable disease was noted in six (46%) patients, with one patient on study for 42 weeks. Riluzole was well tolerated, with fatigue (62%) as the most common adverse event. Downregulation of MAPK and PI3K/AKT was noted in 33% of paired tumor biopsies. Hypothesis‐generating correlative studies suggested that downregulation of angiogenic markers and increased leukocytes at the active edge of tumor correlate with clinical benefit. Pharmacokinetic analysis showed interpatient variability consistent with prior riluzole studies. Future investigations should interrogate mechanisms of biologic activity and advance the development of agents with improved bioavailability.
Kalis — A System for Knowledge-Driven Adaptable Intrusion Detection for the Internet of Things

In this paper, we introduce Kalis, a self-adapting, knowledge-driven expert Intrusion Detection System able to detect attacks in real time across a wide range of IoT systems. Kalis does not require changes to existing IoT software, can monitor a wide variety of protocols, has no performance impact on applications on IoT devices, and enables collaborative security scenarios. Kalis is the first comprehensive approach to intrusion detection for IoT that does not target individual protocols or applications, and adapts the detection strategy to the specific network features. Extensive evaluation shows that Kalis is effective and efficient in detecting attacks to IoT systems.
The Impact of Exercise on Cancer Mortality, Recurrence, and Treatment-Related Adverse Effects

The combination of an increasing number of new cancer cases and improving survival rates has led to a large and rapidly growing population with unique health-care requirements. Exercise has been proposed as a strategy to help address the issues faced by cancer patients. Supported by a growing body of research, major health organizations commonly identify the importance of incorporating exercise in cancer care and advise patients to be physically active. This systematic review comprehensively summarizes the available epidemiologic and randomized controlled trial evidence investigating the role of exercise in the management of cancer. Literature searches focused on determining the potential impact of exercise on 1) cancer mortality and recurrence and 2) adverse effects of cancer and its treatment. A total of 100 studies were reviewed involving thousands of individual patients whose exercise behavior was assessed following the diagnosis of any type of cancer. Compared with patients who performed no/less exercise, patients who exercised following a diagnosis of cancer were observed to have a lower relative risk of cancer mortality and recurrence and experienced fewer/less severe adverse effects. The findings of this review support the view that exercise is an important adjunct therapy in the management of cancer. Implications on cancer care policy and practice are discussed.
Activation and Self-Efficacy in a Randomized Trial of a Depression Self-Care Intervention

Objectives. In a sample of primary care participants with chronic physical conditions and comorbid depressive symptoms: to describe the cross-sectional and longitudinal associations of activation and self-efficacy with demographic, physical and mental health status, health behaviors, depression self-care, health care utilization, and use of self-care tools; and to examine the effects of a depression self-care coaching intervention on these two outcomes. Design/Study Setting. A secondary analysis of activation and self-efficacy data collected as part of a randomized trial to compare the effects of a telephone-based coached depression self-care intervention with a noncoached intervention. Activation (Patient Activation Measure) was measured at baseline and 6 months. Depression self-care self-efficacy was assessed at baseline, at 3 months, and at 6 months. Principal Findings. In multivariable cross-sectional analyses (n = 215), activation and/or self-efficacy were associated with language, birthplace, better physical and mental health, individual exercise, specialist visits, and antidepressant nonuse. In longitudinal analyses (n = 158), an increase in activation was associated with increased medication adherence; an increase in self-efficacy was associated with use of cognitive self-care strategies and increases in social and solitary activities. There were significant improvements from baseline to 6 months in activation and self-efficacy scores both among coached and noncoached groups. The self-care coaching intervention did not affect 6-month activation or self-efficacy but was associated with quicker improvement in self-efficacy. Conclusions. Overall, the results for activation and self-efficacy were similar, although self-efficacy correlated more consistently than activation with depression-specific behaviors and was responsive to a depression self-care coaching intervention.