Miracle-dz/UniFAR-FTUs huggingface dataset:
Accessory cell function of human B cells. I. Production of both interleukin 1-like activity and an interleukin 1 inhibitory factor by an EBV-transformed human B cell line

In the present paper we report that the ROHA -9 cell line, an Epstein- Barr virus (EBV)-transformed human B cell line with accessory cell capabilities, constitutively secretes a soluble factor with the biochemical and biological characteristics of human monocyte-derived IL- 1. The IL-1 derived from ROHA -9 augmented murine thymocyte proliferation and enhanced the proliferative response of human T lymphocytes to concanavalin A (Con A). The ROHA -9-derived IL-1 activity eluted from Sephacryl S-200 in two peaks, at 15- 18K and 32- 35K mol wt, eluted from DEAE-Sephacel at 50-80 and 110-130 mM NaCl, and showed charge heterogeneity with peaks at pI 7.3, 6.1, and 4.1 on isoelectrofocusing (IEF). These findings suggest that B cells may elaborate an IL-1-like activity. During the logarithmic growth of ROHA - 9 cells, a inhibitory factor that inhibited the response of mouse thymocytes to IL-1 was also produced. This factor had a mol wt of 95K on Sephacryl S-200, eluted at 150 mM NaCl on DEAE-Sephacel and showed a peak of pI 4.7 on preparative IEF. The inhibitory factor appeared to be selective in its effects on IL-1 responses, since it did not inhibit the activity of IL-2 on mouse thymocytes or on the growth of the IL-2- dependent CT6 cell line. This "contra-IL-1" inhibited the response of murine thymocytes to suboptimal (1 microgram/ml) but not optimal (10 micrograms/ml) doses of Con A and the response of human peripheral blood lymphocytes to streptolysin O ( SLO ) or to alloantigens. Moreover, the factor could be absorbed by mouse thymocytes but not by CT6 cells, and such thymocytes pretreated with contra-IL-1 failed to response to IL-1. Although this inhibitor is the product of a transformed B cell line, it may be representative of regulatory substances that normally control IL-1 activities either at the extracellular or intracellular level.
Time-Frequency Learning Machines

Over the last decade, the theory of reproducing kernels has made a major breakthrough in the field of pattern recognition. It has led to new algorithms, with improved performance and lower computational cost, for nonlinear analysis in high dimensional feature spaces. Our paper is a further contribution which extends the framework of the so-called kernel learning machines to time-frequency analysis, showing that some specific reproducing kernels allow these algorithms to operate in the time-frequency domain. This link offers new perspectives in the field of non-stationary signal analysis, which can benefit from the developments of pattern recognition and statistical learning theory.
Object Transition Sequences: A New Form of Abstraction for HTN Planners

This paper presents EMS, an implemented HTN planning algorithm using a novel form of abstraction. A plan is viewed as a set of dynamic objects taking part in sequences of transitions. EMS builds up plans using an Expand then Make-Sound cycle: a plan is built up by constructing and expanding a tree of networks at different levels of abstraction, where a network contains object transition sequences. A network is made sound by adjusting the pre and postconditions of all the object transition sequences it contains, and proving the sequence in between is sound. As new objects are discovered in the detailed levels of the hierarchically developing plan, the pre and postconditions of their transition sequences are passed up to a parent network in the; hierarchy which must then be made sound. The main benefits of EMS are that it processes an expressive, declarative input language based on object hierarchies; it is efficient in its reasoning, in that object transition sequences can be manipulated independently of objects of unrelated sorts, and reasoning about condition achievement is performed locally in a network; and it provides a clear, sound algorithm with the potential of application to complex applications.
The role of matrix proteins in the control of nacreous layer deposition during pearl formation

To study the function of pearl oyster matrix proteins in nacreous layer biomineralization in vivo, we examined the deposition on pearl nuclei and the expression of matrix protein genes in the pearl sac during the early stage of pearl formation. We found that the process of pearl formation involves two consecutive stages: (i) irregular calcium carbonate (CaCO3) deposition on the bare nucleus and (ii) CaCO3 deposition that becomes more and more regular until the mature nacreous layer has formed on the nucleus. The low-expression level of matrix proteins in the pearl sac during periods of irregular CaCO3 deposition suggests that deposition may not be controlled by the organic matrix during this stage of the process. However, significant expression of matrix proteins in the pearl sac was detected by day 30–35 after implantation. On day 30, a thin layer of CaCO3, which we believe was amorphous CaCO3, covered large aragonites. By day 35, the nacreous layer had formed. The whole process is similar to that observed in shells, and the temporal expression of matrix protein genes indicated that their bioactivities were crucial for pearl development. Matrix proteins controlled the crystal phase, shape, size, nucleation and aggregation of CaCO3 crystals.
Global integration in the banking industry

Lowered regulatory barriers and advances in technology have reduced the cost of supplying banking services across borders. At the same time, growth in activity by multinational corporations has increased the demand for international financial services. As a result, many observers believe that global integration is under way in the banking industry, that banks are expanding their reach across borders, and that many banking markets will therefore develop large foreign components. The authors report on a study conducted by them, along with Qinglei Dai and Steven Ongena, that examined the nationality and international reach of banks that provide short-term financial services across Europe to affiliates of multinational corporations. The present article also looks at time-series data that provide a more recent look at the progress of integration in Europe. Based on a 1996 survey of more than 2,000 affiliates, the study found that an affiliate is most likely to choose a bank headquartered in the nation in which it is operating (a host-nation bank) rather than a bank headquartered in the home country of the affiliate or in a third nation. The affiliate is also more likely to select a bank limited to local or regional operations rather than one with global reach. The findings are consistent with the proposition that affiliates most value a bank that understands the culture, business practices, and regulatory conditions of the country in which the affiliate operates, and that host-nation banks possess a competitive advantage over other banks in this regard. The time-series data--on syndicated loans, foreign bank claims, and the dispersion of consumer goods prices across Europe--are also consistent with the picture drawn from the 1996 survey. The article concludes that banking markets evidently need not become more integrated even as economic activity otherwise becomes increasingly global.
Free Energy Approximations for CSMA Networks

In this paper we study how to estimate the back-off rates in an idealized CSMA network consisting of n links to achieve a given throughput vector using free energy approximations. More specifically, we introduce the class of region-based free energy approximations with clique belief and present a closed form expression for the back-off rates based on the zero gradient points of the free energy approximation (in terms of the conflict graph, target throughput vector and counting numbers). Next we introduce the size k_max clique free energy approximation as a special case and derive an explicit expression for the counting numbers, as well as a recursion tocompute the back-off rates. We subsequently show that the size k_max clique approximation coincides with a Kikuchi free energy approximation and prove that it is exact on chordal conflict graphs when k_max = n. As a by-product these results provide us with an explicit expression of a fixed point of the inverse generalized belief propagation algorithm for CSMA networks.Using numerical experiments we compare the accuracy of the novel approximation method with existing methods.
Are Euro Cash Holdings in Central and Eastern Europe Driven by Experience or Anticipation? Results from an OeNB Survey

Although euroization is an important phenomenon in emerging markets, still very little is known about who holds how much euro and for what purposes. In this paper, we employ unique survey data to analyze various aspects of foreign currency holdings in five Central and Eastern European countries (CEECs). This allows us to study the impact of expectations and hysteresis on individual behavior. Our results show that a substantial share of the population in the countries under review holds euro cash. We fi nd little evidence that infl ation or exchange rate expectations are important determinants of euroization, whereas variables related to a country’s economic history seem to be of some significance. Our results also indicate that the demand for euro and its use in domestic payments increases as the date of euro adoption approaches.
Structural Biology Communications Structural Basis for the Inhibition of Poly(adp- Ribose) Polymerases 1 and 2 by Bmn 673, a Potent Inhibitor Derived from Dihydropyridophthalazinone

PDB references: catPARP1–BMN 673, 4pjt; catPARP2–BMN 673, 4pjv Poly(ADP-ribose) polymerases 1 and 2 (PARP1 and PARP2), which are involved in DNA damage response, are targets of anticancer therapeutics. BMN 673 is a novel PARP1/2 inhibitor with substantially increased PARP-mediated tumor cytotoxicity and is now in later-stage clinical development for BRCA-deficient breast cancers. In co-crystal structures, BMN 673 is anchored to the nicotinamide-binding pocket via an extensive network of hydrogen-bonding and-stacking interactions, including those mediated by active-site water molecules. The novel di-branched scaffold of BMN 673 extends the binding interactions towards the outer edges of the pocket, which exhibit the least sequence homology among PARP enzymes. The crystallographic structural analyses reported here therefore not only provide critical insights into the molecular basis for the exceptionally high potency of the clinical development candidate BMN 673, but also new opportunities for increasing inhibitor selectivity.
The Self-Regulated Growth of Supermassive Black Holes

We present a series of simulations of the self-regulated growth of supermassive black holes (SMBHs) in galaxies via three different fueling mechanisms: major mergers, minor mergers, and disk instabilities. The SMBHs in all three scenarios follow the same black hole fundamental plane (BHFP) and correlation with bulge binding energy seen in simulations of major mergers, and observed locally. Furthermore, provided that the total gas supply is significantly larger than the mass of the SMBH, its limiting mass is not influenced by the amount of gas available or the efficiency of black hole growth. This supports the assertion that SMBHs accrete until they reach a critical mass at which feedback is sufficient to unbind the gas locally, terminating the inflow and stalling further growth. At the same time, while minor and major mergers follow the same projected correlations (e.g., the MBH-σ and Magorrian relations), SMBHs grown via disk instabilities do not, owing to structural differences between the host bulges. This finding is supported by recent observations of SMBHs in pseudobulges and bulges in barred systems, as compared to those hosted by classical bulges. Taken together, this provides support for the BHFP and binding energy correlations as being more “fundamental” than other proposed correlations in that they reflect the physical mechanism driving the coevolution of SMBHs and spheroids.
Lens-integrated THz imaging arrays in 65nm CMOS technologies

THz CMOS imagers integrated with hyperhemispherical Si-lenses are presented and characterized. FPAs are implemented in 65nm CMOS bulk and SOI technologies. Lens-integrated detectors at 0.65 THz show an increase of 15dB and 20dB in SNR compared to front-side illumination for SOI and bulk respectively. The responsivities Rv are increased and a minimum noise-equivalent power NEP of 17pW/√Hz is measured for SOI detectors with the lens. THz Images are presented.
Properties of Resolved Star Clusters in M51

We present a study of compact star clusters in the nearby pair of interacting galaxies NGC 5194/5195 (M51), based on multifilter Hubble Space Telescope (HST) WFPC2 archival images. We have detected ∼400 isolated, resolved clusters in five HST WFPC2 fields of the two-galaxy system. Due to our requirement that the clusters be detected based only on their morphology, which results in the selection of relatively isolated objects, we estimate that we are missing the majority (by a factor of 4–6) of clusters younger than ∼10 Myr due to the extreme crowding in the spiral arms and star-forming regions. Hence, we focus on the cluster population older than 10 Myr. An age distribution of the detected clusters shows a broad peak between 100 and 500 Myr, which is consistent with the crossing times of the companion galaxy NGC 5195 through the NGC 5194 disk estimated in both single- and multiple-passage dynamical models. We estimate that the peak contains ∼2.2–2.5 times more clusters than expected from a constant rate of cluster formation over this time interval. While there is also evidence for individual peaks near 100 and 500 Myr in the cluster age distribution (consistent with the predictions of multiple-passage models), this result requires verification. We estimate the effective radii of our sample clusters and find a median value of ∼3–4 pc. In addition, we see correlations of (increasing) cluster size with cluster mass (with a best-fit slope of 0.14 ± 0.03) at the ∼4 σ level, and with cluster age (0.06 ± 0.02) at the 3 σ level. Finally, we report for the first time the discovery of faint, extended star clusters in the companion, NGC 5195, an SB0 galaxy. These have red [(V - I) > 1.0] colors and effective radii >7 pc, and are scattered over the disk of NGC 5195. Our results therefore indicate that NGC 5195 is currently the third known barred lenticular galaxy to have formed so-called faint fuzzy star clusters.
PENGARUH KONSEP DIRI DAN KEPERCAYAAN DIRI TERHADAP PERILAKU KONSUMTIF PEMBELIAN GADGET PADA MAHASISWA FAKULTAS HUKUM NON REGULER UNIVERSITAS ISLAM RIAU

This research was conducted at the Faculty of Law, Islamic University of Riau. The purpose of this study was to determine the effect of Self-concept and self-confidence with consumer behavior on non-regular students in the faculty of law, Islamic University of Riau. Data collection techniques used was a questionnaire which amounted to 41 items to the behavior of the consumer variable (Y), 39 items questionnaire for self-concept variables (X1) and 44 items for self-confidence variable (X2) were distributed to 88 non-regular student in faculty of law. Data were analyzed using multiple linear regression analysis technique. Based on the research results it can be concluded that there is a significant positive relationship between self-concept and self-esteem with the consumer behavior of gadget purchases on non-regular students in the faculty of law. The magnitude of the relationship between interpersonal communication variables (X1) and confidence variables (X2) provide an effective contribution to the adjustment (Y) of 70.10%. Thus it can be assumed that the intensity of consumer behavior gadget purchases done by the students and the individual's self-concept improves the confidence in the students' environment. Keywords: consumer behavior, self concept, Confidence
The triple system HIP 96515: a low-mass eclipsing binary with a DB white dwarf companion

Context. HIP 96515 A is a double-lined spectroscopic binary included in the SACY catalog as a potential young star. It has a visual companion (CCDM 19371-5134 B, HIP 96515 B) at 8. �� 6. If bound to the primary, the optical and infrared colors of this wide companion are consistent with those of a white dwarf. Aims. We attempt to characterize the system HIP 96515 A&B by studying each of its components. Methods. We analyzed spectroscopic and photometric observations of HIP 96515 A and its visual companion, HIP 96515 B. To confirm the system as a common proper-motion pair, we analyzed the astrometry of the components using high-angular resolution infrared observations obtained within a time span of two years, and archival astrometry. Results. The high-resolution optical spectrum of HIP 96515 A was used to derive a mass ratio, M2/M1, close to 0.9. The optical lightcurve of HIP 96515 A shows periodic variations with Porbital = 2.3456 days, revealing that HIP 96515 A is an eclipsing binary with preliminary orbital parameters of i = 89. ◦ 0 ± 0. ◦ 2, and M 1
Impact of packet loss on CACC string stability performance

Recent development in wireless technology enables communication between vehicles. The concept of Co-operative Adaptive Cruise Control (CACC) — which uses wireless communication between vehicles — aims at string stable behaviour in a platoon of vehicles. “String stability” means any non-zero position, speed, and acceleration errors of an individual vehicle in a string do not amplify when they propagate upstream. In this paper, we will discuss the string stability of CACC and evaluate its performance with various packet loss ratios, beacon sending frequencies and time headway in simulations. The simulation framework is built up with a controller prototype, a traffic simulator, and a network simulator.
European Academy of Management Conference 2003

Trust is considered to be an appropriate way to meet the challenges inherent in transnational business cooperation. The present empirical study distinguishes between personand organization-oriented trust and explores possible relationships with performance measures such as 'goal achievement' and 'development of profit'. The characteristic of our study is that it comprises a six country comparison. We are able to show significant differences between the countries with respect to the degrees of personas well as organization-oriented trust. We also provide empirical evidence for a relationship between trust and performance, however the results are very heterogeneous and country specific. Torsten M. Kühlmann Institute for Human Resource Management University of Bayreuth 95440 Bayreuth Germany Tel. (++49) 921-55 29 52 Fax (++49) 921-55 29 54 Torsten.Kuehlmann@uni-bayreuth.de Nada Endrissat Institute for Human Resource Management University of Bayreuth 95440 Bayreuth Germany Tel. (++49) 921-55 29 53 Fax (++49) 921-55 29 54 Nada.Endrissat@uni-bayreuth.de
Two LcbHLH Transcription Factors Interacting with LcMYB1 in Regulating Late Structural Genes of Anthocyanin Biosynthesis in Nicotiana and Litchi chinensis During Anthocyanin Accumulation

Anthocyanin biosynthesis requires the MYB-bHLH-WD40 protein complex to activate the late biosynthetic genes. LcMYB1 was thought to act as key regulator in anthocyanin biosynthesis of litchi. However, basic helix-loop-helix proteins (bHLHs) as partners have not been identified yet. The present study describes the functional characterization of three litchi bHLH candidate anthocyanin regulators, LcbHLH1, LcbHLH2, and LcbHLH3. Although these three litchi bHLHs phylogenetically clustered with bHLH proteins involved in anthcoyanin biosynthesis in other plant, only LcbHLH1 and LcbHLH3 were found to localize in the nucleus and physically interact with LcMYB1. The transcription levels of all these bHLHs were not coordinated with anthocyanin accumulation in different tissues and during development. However, when co-infiltrated with LcMYB1, both LcbHLH1 and LcbHLH3 enhanced anthocyanin accumulation in tobacco leaves with LcbHLH3 being the best inducer. Significant accumulation of anthocyanins in leaves transformed with the combination of LcMYB1 and LcbHLH3 were noticed, and this was associated with the up-regulation of two tobacco endogenous bHLH regulators, NtAn1a and NtAn1b, and late structural genes, like NtDFR and NtANS. Significant activity of the ANS promoter was observed in transient expression assays either with LcMYB1-LcbHLH1 or LcMYB1-LcbHLH3, while only minute activity was detected after transformation with only LcMYB1. In contrast, no activity was measured after induction with the combination of LcbHLH2 and LcMYB1. Higher DFR expression was also oberseved in paralleling with higher anthocyanins in co-transformed lines. LcbHLH1 and LcbHLH3 are essential partner of LcMYB1 in regulating the anthocyanin production in tobacco and probably also in litchi. The LcMYB1-LcbHLH complex enhanced anthocyanin accumulation may associate with activating the transcription of DFR and ANS.
Tensor product of Vertex operator algebras

Let $V_1 \otimes V_2$ be a tensor product of VOAs. Using Zhu theory we discuss the theory of representations of V (associative algebra, modules and fusion rules). We prove that this theory is more or less the same as representation theory of tensor product of the associative algebras.
Green on the Screen: Types of Jealousy and Communicative Responses to Jealousy in Romantic Comedies

ABSTRACT Romantic jealousy is common within romantic relationships, yet there is a lack of research on media portrayals of romantic jealousy and subsequent communicative responses to jealousy. Motivated by script theory and social cognitive theory, this study is a content analysis of types of romantic jealousy and communicative responses to jealousy in the 51 top-grossing romantic comedies released between 2002 and 2014. Results indicate that reactive jealousy was the most frequently depicted type of romantic jealousy in these movies, and destructive communication was the most common response. Furthermore, the type of romantic jealousy was significantly related to the type of communicative response the character employed, and females were more likely to use rival-focused communicative responses than males.
Job insecurity and turnover intention: Organizational commitment as mediator

Drawing from social exchange theory, we investigated the relationship between job insecurity and turnover intention, and the mediating effect of organizational commitment on this relationship. Structural equation modeling was employed to investigate the hypotheses using data from 459 employees in various firms in South Korea. Our findings confirmed that job insecurity was positively related to turnover intention, and that organizational commitment mediated the relationship between job insecurity and turnover intention. Implications of our findings for the job insecurity literature are discussed in the Korean context, and directions for future research are given.