Miracle-dz/UniFAR-FTUs huggingface dataset:
Estradiol supplementation modulates neuroendocrine response to M-chlorophenylpiperazine in menstrual status migrainosus triggered by oral contraception-free interval.

BACKGROUND Migraine triggered by oral contraception (OC)-free interval is very common and may be extremely severe, long-lasting and poorly responsive to analgesics (status migrainosus). The serotoninergic (5-HT) system is crucially involved in pain threshold and it is sensitive to estradiol (E2). Therefore, we aimed to assess neuroendocrine correlates of OC status migrainosus in response to the direct central 5-HT agonist meta-chlorophenylpiperazine (m-CPP) and to test the effect of transdermal E2 supplementation of the OC-free interval. METHODS Clinical investigative protocol, single-blinded placebo-controlled treatment. Oral m-CPP (0.5 mg/kg body weight) challenge test was performed in 10 patients with status migrainosus occurring within 48 h of the discontinuation of a monophasic pill (30 microg of ethinyl estradiol and 150 microg of desogestrel) and in six healthy women assuming the same OC as controls. In a consecutive menstrual cycle, patients with OC status migrainosus underwent to the same test after they were blindly treated with 2.0 g of percutaneous E2 gel or placebo daily during the pill-free interval. Plasma prolactin and cortisol levels and clinical characteristics of migraine attacks were evaluated. RESULTS Women with OC-status migrainosus showed a derangement of prolactin release (F = 4.8; P < 0.01) and a lack of cortisol response (F = 5.8; P < 0.001) after m-CPP in comparison with controls. Transdermal E2 during the pill-free interval significantly restored prolactin (F = 2.8; P < 0.01) and cortisol responses (F = 18.9; P < 0.001) against placebo and positively affected the duration (P < 0.001), the number of hours in which pain intensity prohibits daily activity (P < 0.001), the episodes of vomiting (P < 0.001) and the consumption of analgesics (P < 0.001). CONCLUSIONS Status migrainosus triggered by OC-free interval is associated with impaired prolactin and cortisol responses following m-CPP challenge. Transdermal E2 supplementation is able to restore neuroendocrine response to this specific 5-HT agent, exerting a positive clinical effect on the course of menstrually related migraine.
Impersonal Sociotechnical Capital, ICTs, and Collective Action Among Strangers

The notion of “capital” suggests a resource that can be accumulated and whose availability allows people to create value for themselves or others. People can do more when they have access to physical resources like buildings and tools, which are usually referred to as “physical capital”. Money, or “financial capital”, allows people to acquire many other kinds of resources. In the latter half of the 20th century, economists began to think about education as “human capital”. People who have more knowledge and skills can produce more, so it makes sense to think about spending on education as a form of investment rather than consumption [1]. Productive resources can reside not just in things and in people, but also in social relations among people [2, 3]. Following Coleman [2], I define “social capital” as productive resources that inhere in social relations. In order to give the concept greater specificity, analysts sometimes restrict the definition to particular kinds of social relations, such as networks of interpersonal communication, trust, and intimacy, or widespread social trust, or norms of reciprocity. Equating social capital with any particular pattern of social relations, however, would make it impossible to identify as social capital any new patterns of social relations.
MYB82 functions in regulation of trichome development in Arabidopsis

Trichome initiation and patterning are controlled by the TTG1–bHLH–MYB regulatory complex. Several MYB transcription factors have been determined to function in trichome development via incorporation into this complex. This study examined the role of MYB82, an R2R3-MYB transcription factor, in Arabidopsis trichome development. MYB82 was revealed to be a nuclear-localized transcription activator. Suppression of MYB82 function by fusion with a dominant repression domain (SRDX) resulted in glabrous leaves, as did overexpression of N-terminal-truncated MYB82. Overexpression of MYB82 genomic sequence, but not its cDNA sequence, led to reduced trichome numbers. Further investigation indicated that at least one of the two introns in MYB82 is essential to the protein’s trichome developmental function. An MYB-binding box was identified in the third exon of MYB82, which was inferred to be crucial for MYB82 function because the mutation of this box interfered with the ability of MYB82 to rescue the gl1 mutant. Protein interaction analysis revealed that MYB82 physically interacts with GLABRA3 (GL3). In addition, MYB82 and GL1 can form homodimers and heterodimers at R2R3-MYB domains, which may explain why their overexpression reduces trichome numbers. These results demonstrate the functional diversification of MYB82 and GL1 in trichome development.
Pengaruh Pengasuhan Ibu Dan Nenek Terhadap Perkembangan Kemandirian Dan Kognitif Anak Usia Prasekolah

This study aimed to analyze the influence of the characteristics of children, mothers, and grandmothers; maternal and grandmother parenting style; mother-child and grandmother-grandchild attachment on the development of autonomy and cognitive of preschool children. Participants in this study were 156 respondents (52 preschoolers, 52 working mothers and 52 grandmothers). The data used in this study were primary data (interview and observation method). Processing and analyzing data was done by descriptive (cross tabulation) and inferential (t-test, one way ANOVA and regression) test. The results showed that mothers and grandmothers applied good parenting and attachment. In addition, children were taken care of grandmother have good development of autonomy and cognitive. Research found that the younger mother, the lower level of education of mother and grandmother, the increase of authoritative parenting styles of mother, the decrease of parenting style of authoritarian mother, and the increase of grandmother-grandchild attachment will affect the increase of autonomy of preschool children. Meanwhile, the younger grandmother, the lower education of grandmother, the older children when they were first raised by grandmother, the increase of mother-child and grandmother-grandchild attachment influence significantly the increase of child's cognitive development. The role of the grandmother found to be significant in this study.
RAPID NAMING IN CHILDREN WITH SPECIFIC LANGUAGE IMPAIRMENT AND IN CHILDREN WITH TYPICAL LANGUAGE DEVELOPMENT

Aimed at the detailed insight into the phonological ability of Serbian-speaking children of preschool age, with and without language impairment, the ability of rapid naming was examined. Method: Operationalization of the set goal was carried out by using the Test for evaluating reading and writing pre-skills. In describing and analyzing the obtained data, methods of descriptive and inferential statistics were used. The sample included 120 subjects of both gender, 40 children diagnosed with specific language impairment (SLI), age from 5,11 to 7 years, and 80 children with typical language development (TLD), age between 5,11 and 7 years, with no statistically significant differences in relation to age and gender of the participants. Results: Summing up the overall results and achievements of children with SLI and children with TLD, we concluded that there are statistically significant differences in the rapid naming between children with specific language impairment and children with typical language development. Conclusions: As it is a global trend to work on preventing disorders and obstructions, and phonological skills in this age are a timely indicator of the development of reading and writing skills, the examined children with SLI are at risk for the occurrence of obstructions and disorders in the area of reading and writing abilities.
Why Lying Pays: Truth Bias in the Communication with Conflicting Interests

We conduct experiments of a cheap-talk game with incomplete information in which one sender type has an incentive to misrepresent her type. Although that Sender type mostly lies in the experiments, the Receiver tends to believe the Sender's messages. This confirms ``truth bias'' reported in communication theory in a one-shot, anonymous environment without nonverbal cues. These results cannot be explained by existing refinement theories, while a bounded rationality model explains them under certain conditions. We claim that the theory for the evolution of language should address why truthful communication survives in the environment in which lying succeeds.
Daily Stress and Self-Control

People with higher levels of self-control experience fewer stressful life events, but little is known about the reciprocal relationships between self-control and stressful life experiences. This study aimed to test linkages between daily stressors and self-control depletion. We collected web-based survey data twice daily for 14 days from 1,442 participants across the United States and used multilevel modeling to examine relations between daily stressors and self-control depletion. Daily stressors predicted subsequent self-control depletion and self-control depletion predicted daily stressors. Further, the overnight effects remained for self-control depletion on stressors but diminished for the effects of stressors on self-control depletion. Depletion had its weakest impact on participants who reported high mean levels of stressors. These results suggest that stressful events and self-control depletion may create negative spirals, but that these negative spirals can be mitigated by sleep. Further research .
The Association of Deployment-Related Mental Health, Community Support, and Spouse Stress in Military Couples

ABSTRACT Although the Army community can be a source of support, military families experience stressful changes given the unpredictable nature of military life. The present study used data from 124 service member–spouse dyads to examine how service member symptoms of anxiety, depression, and posttraumatic stress are associated with perceived stress in military spouses, taking into account the role of Army integration and community support. Symptoms of anxiety and posttraumatic stress were not associated with perceived stress in the spouse; rather, higher symptoms of depression in the service member were associated with greater levels of stress in the spouse.
Picking Up the Losses: The Impact of the Cultural Revolution on Human Capital Reinvestment in Urban China

This paper uses the Cultural Revolution in China as a quasi-experiment to analyze the long-term impact of interrupted education during an economic transition with many opportunities that reward educational qualifications. We focus on the remedial human capital investment decisions taken by individuals whose education was interrupted by the Cultural Revolution. We find substantial increases in schooling levels among the adult cohorts as they invest in continuous education to compensate for their interrupted schooling and to take advantage of new opportunities afforded by the economic transition. The initial lower level of education caused by the institutional shock can be largely remedied.
Frameworks for Understanding Art: The Function of Comparative Art Contexts and Verbal Cues

The purpose of this investigation was to study contextual variables that influence the understanding of works of art. A key artwork was introduced to college students with other works of art in three different comparative contexts (same-artist vs. same-theme vs. interdisciplinary). Verbal contextual conditions (cued vs. non-cued) were also manipulated to show whether students rely on explicit verbal prompts to find relationships among works of art. The results of a multiple-choice matching test and an open-ended writing task indicate both types of contextual variables can have a strong impact on what a student looks for and thinks about when examining a work of art. Verbal cues can prompt students to elaborate on possible art meanings. Comparative art contexts containing familiar ideas can reduce the occurrence of misunderstandings if those ideas are explicitly identified for students. These and other findings have a direct bearing on how educational interventions might be structured.
Hepatitis C Virus Activates a Neuregulin-Driven Circuit to Modify Surface Expression of Growth Factor Receptors of the ErbB Family

Recently, the epidermal growth factor (EGF) receptor (EGFR), a member of the ErbB receptor family, and its down-stream signalling have been identified as co-factors for HCV entry and replication. Since EGFR also functions as a heterodimer with other ErbB receptor family members, the subject of the present study was to investigate a possible viral interference with these cellular components. By using genotype 1b replicon cells as well as an infection-based system we found that while transcript and protein levels of EGFR and ErbB2 were up-regulated or unaffected, respectively, HCV induced a substantial reduction of ErbB3 and ErbB4 expression. Down-regulation of ErbB3 expression by HCV involves specificity protein (Sp)1-mediated induction of Neuregulin (NRG)1 expression as well as activation of Akt. Consistently, at transcript level disruption of ErbB3 expression by HCV can be prevented by knockdown of NRG1 or Sp1 expression, whereas reconstitution of ErbB3 protein levels requires inhibition of HCV-induced NRG1 expression and of Akt activity. Interestingly, the NRG1-mediated suppression of ErbB3 expression by HCV results in an enhanced expression of EGFR and ErbB2 on the cell surface, which can be mimicked by siRNA-mediated knockdown of ErbB3 expression. These data delineate a novel mechanism enabling HCV to sway the composition of the ErbB family members on the surface of its host cell by an NRG1-driven circuit and unravels a yet unknown cross-regulation between ErbB3 and the two other family members ErbB2 and EGFR. The shift of the receptor surface expression of the ErbB family towards enhanced expression of ErbB2 and EGFR triggered by HCV was found to promote viral RNA replication and infectivity. This suggests that HCV rearranges expression of ErbB family members to adapt the cellular environment to its requirements.
Antimetastatic Therapies of the Polysulfide Diallyl Trisulfide against Triple-Negative Breast Cancer (TNBC) via Suppressing MMP2/9 by Blocking NF-κB and ERK/MAPK Signaling Pathways

Background Migration and invasion are two crucial steps of tumor metastasis. Blockage of these steps may be an effective strategy to reduce the risk. The objective of the present study was to investigate the effects of diallyl trisulfide (DATS), a natural organosulfuric compound with most sulfur atoms found in garlic, on migration and invasion in triple negative breast cancer (TNBC) cells. Molecular mechanisms underlying the anticancer effects of DATS were further investigated. Methods and Results MDA-MB-231 cells and HS 578t breast cancer cells were treated with different concentrations of DATS. DATS obviously suppressed the migration and invasion of two cell lines and changed the morphological. Moreover, DATS inhibited the mRNA/protein/ enzymes activities of MMP2/9 via attenuating the NF-κB pathway. DATS also inhibited ERK/MAPK rather than p38 and JNK. Conclusion DATS inhibits MMP2/9 activity and the metastasis of TNBC cells, and emerges as a potential anti-cancer agent. The inhibitory effects are associated with down-regulation of the transcriptional activities of NF-κB and ERK/MAPK signaling pathways.
Event recognition: viewing the world with a third eye

Semantic event recognition based only on vision cues is a challenging problem. This problem is particularly acute when the application domain is unconstrained still images available on the Internet or in personal repositories. In recent years, it has been shown that metadata captured with pictures can provide valuable contextual cues complementary to the image content and can be used to improve classification performance. With the recent geotagging phenomenon, an important piece of metadata available with many geotagged pictures now on the World Wide Web is GPS information. In this study, we obtain satellite images corresponding to picture location data and investigate their novel use to recognize the picture-taking environment, as if through a third eye above the object. Additionally, we combine this inference with classical vision-based event detection methods and study the synergistic fusion of the two approaches. We employ both color- and structure-based visual vocabularies for characterizing ground and satellite images, respectively. Training of satellite image classifiers is done using a multiclass AdaBoost engine while the ground image classifiers are trained using SVMs. Modeling and prediction involve some of the most interesting semantic event-activity classes encountered in consumer pictures, including those that occur in residential areas, commercial areas, beaches, sports venues, and parks. The powerful fusion of the complementary views achieves significant performance improvement over the ground view baseline. With integrated GPS-capable cameras on the horizon, we believe that our line of research can revolutionize event recognition and media annotation in years to come.
On the multivariate Nakagami-m distribution with exponential correlation

Capitalizing on the proof of a theorem presented by L.E. Blumenson and K.S. Miller (see Ann. Math. Statist., vol.34, p.903-10, 1963), we propose a useful closed formula for the exponentially correlated n-variate Nakagami-m probability density function. Moreover, an infinite series approach for the corresponding cumulative distribution function is presented. Bounds on the error resulting from the truncation of the infinite series are also derived. Finally, in order to check the accuracy of the proposed formulation, numerical results are presented.
Differential Induction of Functional IgG Using the Plasmodium falciparum Placental Malaria Vaccine Candidate VAR2CSA

Background In Plasmodium falciparum malaria endemic areas placental malaria (PM) is an important complication of malaria. The recurrence of malaria in primigravidae women irrespective of acquired protection during childhood is caused by the interaction between the parasite-expressed VAR2CSA antigen and chondroitin sulfate A (CSA) in the placental intervillous space and lack of protective antibodies. PM impairs fetal development mainly by excessive inflammation processes. After infections during pregnancy women acquire immunity to PM conferred by antibodies against VAR2CSA. Ideally, a vaccine against PM will induce antibody-mediated immune responses that block the adhesion of infected erythrocytes (IE) in the placenta. Principal Findings We have previously shown that antibodies raised in rat against individual domains of VAR2CSA can block IE binding to CSA. In this study we have immunized mice, rats and rabbits with each individual domain and the full-length protein corresponding to the FCR3 VAR2CSA variant. We found there is an inherently higher immunogenicity of C-terminal domains compared to N-terminally located domains. This was irrespective of whether antibodies were induced against single domains or the full-length protein. Species-specific antibody responses were also found, these were mainly directed against single domains and not the full-length VAR2CSA protein. Conclusions/Significance Binding inhibitory antibodies appeared to be against conformational B-cell epitopes. Non-binding inhibitory antibodies reacted highly against the C-terminal end of the VAR2CSA molecule especially the highly polymorphic DBL6ε domain. Differential species-specific induction of antibody responses may allow for more direct analysis of functional versus non-functional B-cell epitopes.
A Monthly Double-blind Peer Reviewed Refereed Open Access International E-journal -included in the International Serial Directories International Journal of Management, It and Engineering a Study of Socio-economic and Entrepreneurial Characteristics of Tribals of Mayurbhanj District in Sabai Grass E

Entrepreneurship is considered as tactical development interference to speed up the process of economic development. The promotion of entrepreneurship is directly related to the socioeconomic development of the poor tribal population of the society. Scheduled tribes constitute the poorest section of population in rural areas of India. They generally depend on forest and agriculture for livelihood. A research study was undertaken in the tribal dominated Mayurbhanj district of Odisha in India . The tribal people in the study area were involved in different agriculture based entrepreneurial activities. In the district cultivation of sabai grass (Eulaliopsis binata) and its processing of consumer goods remain a good enterprise for the tribal entrepreneurs. The study was conducted to examine the socioeconomic , personal characteristics and entrepreneurial characteristics of the tribals in sabai grass enterprise. It is revealed from the study that majority of the respondents belong to low innovativeness, low farm decision making ability, medium level of knowledge, medium risk taking ability, medium level of self confidence, medium level of management orientation, high leadership ability, medium achievement motivation category.
A Large Accumulation of Avian Eggs from the Late Cretaceous of Patagonia (Argentina) Reveals a Novel Nesting Strategy in Mesozoic Birds

We report the first evidence for a nesting colony of Mesozoic birds on Gondwana: a fossil accumulation in Late Cretaceous rocks mapped and collected from within the campus of the National University of Comahue, Neuquén City, Patagonia (Argentina). Here, Cretaceous ornithothoracine birds, almost certainly Enanthiornithes, nested in an arid, shallow basinal environment among sand dunes close to an ephemeral water-course. We mapped and collected 65 complete, near-complete, and broken eggs across an area of more than 55 m2. These eggs were laid either singly, or occasionally in pairs, onto a sandy substrate. All eggs were found apparently in, or close to, their original nest site; they all occur within the same bedding plane and may represent the product of a single nesting season or a short series of nesting attempts. Although there is no evidence for nesting structures, all but one of the Comahue eggs were half-buried upright in the sand with their pointed end downwards, a position that would have exposed the pole containing the air cell and precluded egg turning. This egg position is not seen in living birds, with the exception of the basal galliform megapodes who place their eggs within mounds of vegetation or burrows. This accumulation reveals a novel nesting behaviour in Mesozoic Aves that was perhaps shared with the non-avian and phylogenetically more basal troodontid theropods.
Should Gender Differences Be Considered When Assessing Student Satisfaction in the Online Learning Environment for Millennials

The majority of today’s students in online higher education are millennials and have grown up using technology. Therefore, there is a need to determine if their expectations from online learning are different from previous contextual studies and whether or not these vary across gender. This study used a mixed method approach, using focus groups, followed by online surveys of 834 undergraduate students from the University of Mauritius enrolled in an online course. Using factor analysis and structural equation modelling, the study found no significant differences based on gender for millennials, but identified three significant antecedents of student satisfaction for both males and females: university reputation; physical facilities; and instructor empathy.