Miracle-dz/UniFAR-FTUs huggingface dataset:
Live growth performance, carcass grading characteristics, and harvest yields of beef steers supplemented zilpaterol hydrochloride and offered ad libitum or maintenance energy intake

Abstract A trial was conducted to examine live growth efficiency, harvest yields, and carcass grading performance of steers fed at maintenance (M) or at ad libitum (A) level of intake during zilpaterol hydrochloride (Z) supplementation. Single-sired, beef steers (n = 56; start of trial BW 590 ± 36 kg) blocked (n = 2) by weight and terminal implant were sorted into pairs (n = 14 per block) by weight. Pairs of steers were initially assigned to 0, 28, or 56 d of feeding. Within 28 or 56 d, pairs were assigned to M or A intake. Steers within a pair assigned to 56 d of feeding were randomly assigned to either 20 d of Z supplementation (90 mg/d per steer) with a 4 d withdrawal period prior to slaughter or to no ZH supplementation (C). Steers were housed and fed in individual pens. Weights of all non-carcass and carcass components were recorded at slaughter; carcasses were graded 24-h postmortem. Data were analyzed via a mixed model; the fixed effect was treatment combination with random effects of block and pair. Live growth data used harvest day as the repeated measure and animal as the subject. Single df contrasts were constructed for day 0 vs. day 28, day 0 vs. day 56, day 28 vs. day 56, M vs. A, and C vs. Z. Treatment impacted (P ≤ 0.05) live ADG; contrasts indicated A (1.33) was greater than M (0.14 kg), and Z (1.12) was greater than C (0.82 kg). Similarly, carcass ADG differences (P < 0.01) indicated A (1.04) was greater than M (0.36 kg), and Z (1.35) was greater than C (0.71 kg). Intake level altered BW and empty body weight (EBW); M cattle had reduced BW and EBW (P < 0.01, 585 and 540 kg) than A cattle (647 and 597 kg). Cattle fed at M had less carcass and internal cavity mass (P < 0.01, 359 and 79.4 kg) than A cattle (394 and 93.5 kg). Liver mass was reduced by M feeding (P < 0.01; M-5.03, A-6.69 kg) and Z treatment (P < 0.01; Z-5.64, C-6.06 kg). Moreover, mass of total splanchnic tissue was less (P < 0.01) for M cattle than A cattle (59.8 vs. 72.5 kg). Dressed carcass yield was greater (P < 0.01) for Z than C cattle (63.5 vs. 61.6%). Cattle fed at M had less 12th rib s.c. fat, lower numerical U.S. yield grades (P < 0.01; M-1.71 cm and 3.3, A-2.46 cm and 4.3) and lower numerical Canadian yield grades (P < 0.01; 51.9 vs. 53.9% for M and A, respectively) than A cattle. Results indicate that energy intake level and Z supplementation influence live and carcass growth, carcass transfer, kill yields, and carcass characteristics across time.
Efficacy of olanzapine combined with valproate or lithium in the treatment of dysphoric mania.

BACKGROUND Few controlled studies examine the treatment of depressive features in mania. AIMS To evaluate the efficacy of olanzapine, in combination with lithium or valproate, for treating depressive symptoms associated with mania. METHOD Secondary analysis of a 6-week, double-blind, randomised study of olanzapine (5-20 mg/day) or placebo combined with ongoing valproate or lithium open treatment for 344 patients in mixed or manic episodes. This analysis focused on a dysphoric subgroup with baseline Hamilton Rating Scale for Depression (HRSD) total scores of 20 or over contrasted with non-dysphoric patients. RESULTS In the dysphoric subgroup (n=85) mean HRSD total score improvement was significantly greater in olanzapine co-therapy patients than in those receiving placebo plus lithium or valproate (P<0.001). Substantial contributors to this superiority included the HRSD Maier sub-scale (P=0.013) and the suicide item (P=0.001). Total Young Mania Rating Scale improvement was also superior with olanzapine co-therapy. CONCLUSIONS In patients with acute dysphoric mania, addition of olanzapine to ongoing lithium or valproate monotherapy significantly improved depressive symptom, mania and suicidality ratings.
Visual Performance of a New Extended Depth-of-Focus Intraocular Lens Compared to a Distance-Dominant Diffractive Multifocal Intraocular Lens.

PURPOSE To investigate the clinical performance of a new extended depth-of-focus (EDOF) intraocular lens (IOL) and compare it to that of a distance-dominant diffractive multifocal IOL. METHODS Patients implanted with an EDOF IOL (Mini Well; SIFI, Catania, Italy) inducing spherical aberration and with a multifocal IOL (ReSTOR SV25T; Alcon Laboratories, Inc., Fort Worth, TX) were analyzed. The following monocular parameters were investigated: corrected distance visual acuity (CDVA), distance-corrected near visual acuity (DCNVA), reading speed, defocus curve, contrast sensitivity, and halos and glare as quantified by a simulator (Halo & Glare Simulator; Eyeland-Design Network GmbH, Vreden, Germany) and questionnaire. RESULTS Twenty patients with the EDOF IOL and 37 with the multifocal IOL were enrolled. No statistically significant difference was observed for CDVA. The defocus curve of the EDOF IOL revealed no gaps for the intermediate range. Statistically significant differences were observed at -1.00 diopter (D) (EDOF IOL: 0.08 ± 0.09 logMAR; multifocal IOL: 0.21 ± 0.12 logMAR; P < .0001) and -1.50 D defocus (EDOF IOL: 0.15 ± 0.11 logMAR; multifocal IOL: 0.24 ± 0.13 logMAR; P = .0122). The reading speed at 40 cm was similar at all print sizes. The mean DCNVA was the same (EDOF IOL: 0.35 ± 0.14 logRAD, multifocal IOL: 0.35 ± 0.13 logRAD). No differences in contrast sensitivity were detected. According to the simulator, halos had a smaller mean size (P = .0439) and a lower mean intensity (P = .0222) with the EDOF IOL. No statistically significant differences were detected for glare size. CONCLUSIONS The new EDOF IOL performed similarly to a multifocal IOL at distance and near but was superior at intermediate distances. [J Refract Surg. 2018;34(4):228-235. ].
Reassessing the Potential of Myb-targeted Anti-cancer Therapy

Transcription factor MYB is essential for the tumorigenesis of multiple cancers, especially leukemia, breast cancer, colon cancer, adenoid cystic carcinoma and brain cancer. Thus, MYB has been regarded as an attractive target for tumor therapy. However, pioneer studies of antisense oligodeoxynucleotides against MYB, which were launched three decades ago in leukemia therapy, were discontinued because of their unsatisfactory clinical outcomes. In recent years, the roles of MYB in tumor transformation have become increasingly clear. Moreover, the regulatory mechanisms of MYB, such as the vital effects of MYB co-regulators on MYB activity and of transcriptional elongation on MYB expression, have been unveiled. These observations have underpinned novel approaches in inhibiting MYB. This review discusses the structure, function and regulation of MYB, focusing on recent insights into MYB-associated oncogenesis and how MYB-targeted therapeutics can be explored. Additionally, the main MYB-targeted therapies, including novel genetic therapy, RNA interference, microRNAs and low-molecular-weight compounds, which are especially promising inhibitors that target MYB co-regulators and transcriptional elongation, are described, and their prospects are assessed.
Three dimensional interface modelling with two-dimensional seismic data: the Alpine crust-mantle boundary

SUMMARY We present a new approach to determine the 3-D topography and lateral continuity of seismic interfaces using 2-D-derived controlled-source seismic reflector data. The aim of the approach is to give the simplest possible structure consistent with all reflector data and error estimates. We define simplicity of seismic interfaces by the degree of interface continuity (i.e. shortest length of oVsets) and by the degree of interface roughness (least surface roughness). The method is applied to structural information of the crust‐mantle boundary (Moho) obtained from over 250 controlled-source seismic reflection and refraction profiles in the greater Alpine region. The reflected and refracted phases from the Moho interface and their interpretation regarding crustal thickness are reviewed and their reliability weighted. Weights assigned to each reflector element are transformed to depth errors considering Fresnel volumes. The 2-D-derived reflector elements are relocated in space (3-D migration) and interpolation is performed between the observed reflector elements to obtain continuity of model parameters. Interface oVsets are introduced only where required according to the principle of simplicity. The resulting 3-D model of the Alpine crust‐mantle boundary shows two oVsets that divide the interface into a European, an Adriatic and a Ligurian Moho, with the European Moho subducting below the Adriatic Moho, and with the Adriatic Moho underthrusting the Ligurian Moho. Each sub-interface depicts the smoothest possible (i.e. simplest) surface, fitting the reflector data within their assigned errors. The results are consistent with previous studies for those regions with dense and reliable controlledsource seismic data. The newly derived Alpine Moho interface, however, surpasses earlier studies by its lateral extent over an area of about 600 km by 600 km, by quantifying reliability estimates along the interface, and by obeying the principle of being consistently as simple as possible.
Behavioral and psychosocial factors associated with suicidal ideation among adolescents

Suicidal ideation poses a serious threat to the well-being of adolescents and is the strongest risk factor for suicide. Indeed, Korea ranks first among Organisation for Economic Cooperation and Development countries regarding the age-standardized suicide rates. In the present study, we examined multiple levels of factors associated with the suicidal ideation of adolescents in Korea by applying the Ecological Models of Health Behavior. A cross-sectional study was conducted with a convenience sample of 860 adolescents. The instruments included the Beck Depression Inventory and the Adolescent Mental Health and Problem Behavior Questionnaire. The data were analyzed using hierarchical multiple regression. Sixteen percent of participants reported suicidal ideation. Intrapersonal (sleep disturbance, Internet game addiction, destructive behavior, and depressive symptoms) and interpersonal factors (family conflicts and peer victimization) were associated with suicidal ideation. Because multiple factors were associated with suicidal ideation among adolescents, both intrapersonal (sleep disturbance, Internet game addiction, and depression) and interpersonal factors (family conflicts and peer problems) should be considered in the development of suicide-prevention programs. These programs could include campaigns changing the norms (permissive attitudes toward school violence) and the development of strict and rigorous school non-violence policies.
PD‐L1 expression in tumour‐infiltrating lymphocytes is a poor prognostic factor for primary acral melanoma patients

Programmed cell death protein 1–programmed death‐ligand 1 (PD‐L1) blockade immunotherapy has shown notable therapeutic benefit in metastatic melanoma, but the clinical relevance of PD‐L1 expression remains unclear in melanoma, especially in acral melanoma, which is the most common subtype in Asians. The aim of this study was to evaluate the clinical effect of PD‐L1 expression in primary acral melanoma.
Boron isotope ratio (δ11B) measurements in Water Framework Directive monitoring programs: comparison between double focusing sector field ICP and thermal ionization mass spectrometry

The aim of our research was to compare delta B-11 measurements performed with thermal ionization mass spectrometry (TIMS) and sector field-inductively coupled plasma-mass spectrometry (SF-ICP-MS) and evaluate the feasibility of implementing stable isotope methods in European water framework directive (WFD) monitoring programs. The comparison was based on delta B-11 measurements of 192 ground-and surface water samples and 15 leachates of nitrate pollution source materials (organic and mineral fertilisers). The precision of delta B-11 measurements attainable with SF-ICP-MS, 2 sigma= +/- 2.6 parts per thousand; (n = 192), is as expected lower than the precision achieved by TIMS, 2 sigma= +/- 0.3 parts per thousand (n=183). However the ease of use, rapidity and availability of SF-ICP-MS on one hand and the observed variability in delta B-11 in ground-and surface water on the other (from -3.4 to +37 parts per thousand), demonstrates that using SF-ICP-MS as an isotopic screening method would promote the use of isotopic methodology for WFD monitoring. Based on the results of the different case studies it is shown that retrieving precise information on the identification of pollution sources from delta B-11 values requires reaching the best analytical precision and accuracy possible. Hence, the superior precision of TIMS advantages tracing of nitrate pollution sources. However for some cases, e. g. trying to decipher contributions between sources with really distinct delta B-11 signatures (e.g. manure and sewage effluent), SF-ICP-MS results lead to the same conclusions and can therefore be used as a first approachable screening method for the determination of delta B-11 in WFD monitoring programs.
Validation of refractivity profiles derived from GRAS raw-sampling data

Abstract. Results from GRAS (GNSS Receiver for Atmospheric Sounding) RO (Radio Occultation) data recorded in RS (Raw Sampling) mode processed at the GFZ (German Research Centre for Geoscience) Potsdam are presented. The experimental processing software POCS-X includes FSI (Full Spectrum Inversion) in order to cope with multi-path regions and enables in connection with RS data to retrieve atmospheric refractivity profiles down to the Earths surface. Radio occultation events observed between 30 September and 30 October 2007 are processed and the retrievals are validated against co-located ECMWF (European Centre for Medium-Range Weather Forecasts) profiles. The intercomparison indicates good quality of the retrieved profiles. In the altitude range 8 to 25 km the standard deviation is below 1 %. The mean deviation in this altitude range tends to be negative. At 30 km the negative bias reaches about −0.4 %. Below 8 km the standard deviation increases, reaching 2.5 % at 2 km. Below 2 km the mean deviation tends to be negative, reaching −1.9 % close to the ground. The negative bias mainly stems from the tropical lower troposphere; there, the negative bias reaches −3 %. The tropospheric penetration depth obtained from RS data shows a vast improvement compared to the tropospheric penetration depth typically obtained from CL (Closed Loop) data; 50 % of all retrieved profiles reach 720 m.
Group Hunting—A Reason for Sociality in Molossid Bats?

Many bat species live in groups, some of them in highly complex social systems, but the reasons for sociality in bats remain largely unresolved. Increased foraging efficiency through passive information transfer in species foraging for ephemeral insects has been postulated as a reason for group formation of male bats in the temperate zones. We hypothesized that benefits from group hunting might also entice tropical bats of both sexes to live in groups. Here we investigate whether Molossus molossus, a small insectivorous bat in Panama, hunts in groups. We use a phased antenna array setup to reduce error in telemetry bearings. Our results confirmed that simultaneously radiotracked individuals from the same colony foraged together significantly more than expected by chance. Our data are consistent with the hypothesis that many bats are social because of information transfer between foraging group members. We suggest this reason for sociality to be more widespread than currently assumed. Furthermore, benefits from group hunting may also have contributed to the evolution of group living in other animals specialized on ephemeral food sources.
It Had to Be You (Not Me)!

We investigated the tendency of women to undervalue their contributions in collaborative contexts. Participants, who believed they were working with another study participant on a male sex-typed task, received positive feedback about the team’s performance. Results indicated that women and men allocated credit for the joint success very differently. Women gave more credit to their male teammates and took less credit themselves unless their role in bringing about the performance outcome was irrefutably clear (Studies 1 and 2) or they were given explicit information about their likely task competence (Study 4). However, women did not credit themselves less when their teammate was female (Study 3). Together these studies demonstrate that women devalue their contributions to collaborative work, and that they do so by engaging in attributional rationalization, a process sparked by women’s negative performance expectations and facilitated by source ambiguity and a satisfactory “other” to whom to allocate credit.
Gender differences in the factors predicting initial engagement at cardiac rehabilitation

Objective To determine whether there are gender differences in the factors that predict attendance at the initial cardiac rehabilitation baseline assessment (CR engagement) after referral. Methods Using data from the National Audit of Cardiac Rehabilitation, we analysed data on 95 638 patients referred to CR following a cardiovascular diagnosis/treatment between 2013 and 2016. Eighteen factors that have been shown in previous research to be important predictors of CR participation were investigated and grouped into four categories: sociodemographic factors, cardiac risk factors, patient medical status and service-level factors. Logistic binary regression models were built for male patients and female patients, assessing the likelihood for CR engagement. Each included predictors such as age, number of comorbidities and social deprivation score. Results There were no important differences in the factors that predict the likelihood of CR engagement in men and women. Seven factors associated with a reduced probability of CR engagement, and eight factors associated with increased probability, were identified. Fourteen of the 15 factors identified as predicting the likelihood for engagement/non-engagement were the same for both men and women. Increasing age, being South Asian or non-white ethnicity (other than Black) and being single were all associated with a reduced likelihood of attending an initial CR baseline assessment in both men and women. Male patients with diabetes were 11% less likely to engage with CR; however, there was no significant association in women. Results showed that the overwhelmingly important determinant of CR engagement observed in both men and women was receiving an invitation to attend an assessment session (OR 4.223 men/4.033women; p<0.05). Conclusions Consideration of gender differences in predictors of CR uptake should probably be more nuanced and informed by the stage of the patient care pathway.
Preparation and Optimization of Rivaroxaban by Self-Nanoemulsifying Drug Delivery System (SNEDDS) for Enhanced Oral Bioavailability and No Food Effect

In this paper, a novel self-nanoemulsifying drug delivery system (SNEDDS) was used to improve the oral bioavailability in fasted state and diminish the food effect for rivaroxaban. Oil, surfactant, and co-surfactant were selected by saturated solubility study. IPM, Tween80, and 1,2-propanediol were finally selected as oil, surfactant, and co-surfactant, respectively. The pseudo-ternary-phase diagram was utilized to optimize the preliminary composition of SNEDDS formulation. The optimized rivaroxaban-SNEDDS formulation was selected by central composite design (CCD) of response surface methodology. Optimized SNEDDS formulation was evaluated for drug content, self-emulsifying time, droplet size, zeta potential, polydispersity index, Fourier transform-infrared (FTIR) spectroscopy, and transmission electron microscope (TEM). The drug dissolution profile compared to the commercial formulation Xarelto® (20 mg rivaroxaban) was determined in four different media (pH 1.2HCl, pH 4.5NaAc-HAc, pH 6.8PBS, and water). The result indicated that the SNEDDS formulation had successfully increased the drug solubility in four different media. A HPLC-MS method that indicated a high sensitivity, strong attribute, and high accuracy characteristic was built to measure the drug concentration in plasma. The fast/fed in vivo pharmacokinetics studies of SNEDDS formulation and Xarelto® were carried out in adult beagle dog, rivaroxaban with no food effect was achieved in SNEDDS formulation compared with Xarelto® in fed state. The result suggested that SNEDDS formulation in this study is useful to increase the oral bioavailability and diminish the food effect in fasted state.
Ginger Phytochemicals Exhibit Synergy to Inhibit Prostate Cancer Cell Proliferation

Dietary phytochemicals offer nontoxic therapeutic management as well as chemopreventive intervention for slow-growing prostate cancers. However, the limited success of several single-agent clinical trials suggest a paradigm shift that the health benefits of fruits and vegetables are not ascribable to individual phytochemicals, rather may be ascribed to synergistic interactions among them. We recently reported growth-inhibiting and apoptosis-inducing properties of ginger extract (GE) in in vitro and in vivo prostate cancer models. Nevertheless, the nature of interactions among the constituent ginger biophenolics, viz. 6-gingerol, 8-gingerol, 10-gingerol, and 6-shogoal, remains elusive. Here we show antiproliferative efficacy of the most-active GE biophenolics as single-agents and in binary combinations, and investigate the nature of their interactions using the Chou-Talalay combination index (CI) method. Our data demonstrate that binary combinations of ginger phytochemicals synergistically inhibit proliferation of PC-3 cells with CI values ranging from 0.03 to 0.88. To appreciate synergy among phytochemicals present in GE, the natural abundance of ginger biophenolics was quantitated using LC-UV/MS. Interestingly, combining GE with its constituents (in particular, 6-gingerol) resulted in significant augmentation of GE's antiproliferative activity. These data generate compelling grounds for further preclinical evaluation of GE alone and in combination with individual ginger biophenols for prostate cancer management.
Relationship between Burnout and Body Mass Index in Senior and Middle Managers from the Mexican Manufacturing Industry

This research relates Burnout Syndrome (BS) with the Body Mass Index (BMI) among middle and senior managers of the Mexican manufacturing industry. Even though BS incidence is high in the Mexican industrial population, few systematic studies have explored BS and its relationship with other health problems, such as obesity. The goal of this research is to determine the relationship between BS and the BMI in employees with normal weight, overweight, and obesity. We present three structural equation models to relate BS and the BMI. The BMI ranges were determined according to the parameters (normal weight, overweight, and obesity) proposed by the World Health Organization (WHO). The sample includes 361 employees that voluntarily answered a 31-item questionnaire. We measure the levels of BS using the Maslach Burnout Inventory–General Survey (MBI-GS) and analyze anthropometric and sociodemographic data from the participants. Then, we determine the relationships between the variables through structural equation models and estimate the direct, indirect, and total effects in the three models, which show acceptable reliability. As main findings, the normal weight model has a larger explanatory power than the overweight and obesity models. The same research hypotheses were tested and the effects of BS on the BMI differ across the three models. Such results are presented by taking into account that obesity and overweight require additional factors, such as genetic factors and personal eating habits, to be better explained.