Miracle-dz/UniFAR-FTUs huggingface dataset:
Community Dynamics in the Mouse Gut Microbiota: A Possible Role for IRF9-Regulated Genes in Community Homeostasis

Background Gut microbial communities of mammals are thought to show stable differences between individuals. This means that the properties imparted by the gut microbiota become a unique and constant characteristic of the host. Manipulation of the microbiota has been proposed as a useful tool in health care, but a greater understanding of mechanisms which lead to community stability is required. Here we have examined the impact of host immunoregulatory phenotype on community dynamics. Methods and Findings Denaturing gradient gel electrophoresis was used to analyse the faecal bacterial community of BALB/c and C57BL/6 mice and C57BL/6 mice deficient for either type I interferon (IFN) signalling (IRF9 KO mice) or type I and type II IFN signalling (STAT1 KO mice). Temporal variation was found in all mouse strains. A measure of the ability for a community structure characteristic of the host to be maintained over time, the individuality index, varied between mouse strains and available data from pigs and human models. IRF9 KO mice had significantly higher temporal variation, and lower individuality, than other mouse strains. Examination of the intestinal mucosa of the IRF9 KO mice revealed an increased presence of T-cells and neutrophils in the absence of inflammation. Significance The high temporal variation observed in the gut microbiota of inbred laboratory mice has implications for their use as experimental models for the human gut microbiota. The distinct IRF9 and STAT1 phenotypes suggest a role for IRF9 in immune regulation within the gut mucosa and that further study of interferon responsive genes is necessary to understand host-gut microbe relationships.
Perseveration in Normal Aging: A Comparison of Perseveration Rates on Design Fluency and Verbal Generative Tasks

Three generative tasks (design generation, animal naming, words starting with m) from the Cognitive Linguistic Quick Test were administered to 73 healthy individuals in four age groups (18–39, 40–59, 60–74, 75–88) and scored for perseveration and productivity. Perseveration rates for design generation were significantly higher, and increased linearly as a function of age. The number of individuals who perseverated at least once on design generation also increased linearly, with highest prevalence in the oldest group. No age effects were found for perseveration on the verbal naming tasks. Perseverations across tasks were independent of one another. The design generation task may require multiple simultaneous processing skills, placing more demand on compromised executive processing in the elderly.
'That kind of girl in this kind of neighbourhood …' The potential and problems of street prostitution research

The researcher can never be a detached observer. In this paper Sirpa Tani explores the dynamic between researcher and research 'field', and the methodological challenges she encountered living in a neighbourhood which became the subject of her own research into street prostitution in Helsinki, Finland. The idea in traditional ethnographic fieldwork that the researcher enters the field, gathers data, and withdraws to report findings in the comfort of academia is challenged by this close proximity to the subject. Tani's surveys of the attitudes and feelings of local women who have been mistakenly approached as sex workers have to be interpreted alongside her own experiences of these situations. How are we to begin to address such transient and elusive activities in the city, using what data, and with what research output in mind? How can the publication of such research avoid falling into the trap of reproducing the negative meanings attached to an area, through media representation, and the complex processes of "othering" underlying the city's spatial configurations?
Effect of Surgery on Pancreatic Tumor-Dependent Lymphocyte Asset

Objectives Tumor burden and invasiveness establish a microenvironment that surgery could alter. This study shows a comprehensive analysis of size, dynamics, and function of peripheral lymphocyte subsets in pancreatic cancer patients before and at different times after duodenopancreatectomy. Methods Lymphocyte frequency and natural cytotoxicity were evaluated by flow cytometry and in vitro assay on peripheral blood from initial and advanced-stage pancreatic cancer patients before (BS), at day 7 (PS7), and at day 30 (PS30) after surgery. Results An increase in natural killer (NK) cells and the diminution of B-cells occurred at PS30, whereas cytotoxicity decreased at PS7. The positive correlation between NK frequency and cytotoxicity at BS and PS7 revealed an altered NK behavior. The elevation of NK cell frequency at PS30, an initial defect in CD56bright NK, and the aberrant correlation between NK frequency and cytotoxicity remained significant in advanced-stage patients, whereas the diminution of NK cytotoxicity only affected initial stage patients. Conclusions The NK cell functional ability is altered in presurgery patients; duodenopancreatectomy is associated with short-term impairment of NK function and with a long-term NK cell augmentation and reversion of the aberrant NK behavior, which may impact on immunosurveillance against residual cancer.
Prevalence of exfoliation syndrome in central Sri Lanka: the Kandy Eye Study

Aims: To report the prevalence and correlates of exfoliation syndrome (XFS) in central, rural Sri Lanka. Methods: A population-based, cross-sectional ophthalmic survey of inhabitants 40 years of age and over from villages in the Kandy District was conducted. Selection was randomised using a cluster sampling process. 1721 eligible participants were identified, 1375 participated. A detailed ophthalmic history and examination including ocular biometry was made of each participant. Results: The prevalence of XFS was estimated to be 1.1% (95% CI 0.5 to 1.5%; 22 eyes). XFS was bilateral in eight subjects, unilateral in six subjects. Univariate analysis demonstrated a significant association between XFS and increasing age (p<0.001), increasing intraocular pressure (odds ratio 1.2; 95% CI 1.09 to 1.27; p<0.001), nuclear cataracts (odds ratio 1.92; 95% CI 1.47 to 2.51; p<0.001), visual impairment (odds ratio 9.72; 95% CI 3.01 to 31.44; p<0.001) and a history of hypertension (odds ratio 3.89; 95% CI 1.14 to 13.16; p = 0.030). Conclusion: XFS in this Sri Lankan population was associated with advanced age, raised intraocular pressure, nuclear cataracts, hypertension and visual impairment.
Abnormal Cortical Mechanisms in Voluntary Muscle Relaxation in De Novo Parkinsonian Patients

This study aimed at elucidating how the cortical mechanism underlying the preparation and the postmovement phase of voluntary hand muscle relaxation is affected in Parkinson’s disease. Event-related mu and beta (de)synchronization (ERD/S) related to voluntary muscle contraction and relaxation were recorded in 16 untreated, akineto-rigid, predominantly hemiparkinsonian patients. The results were compared with data from 10 age-matched, healthy subjects. In the muscle relaxation task, the subject held the wrist in an extended position and then let the hand drop by voluntarily relaxing wrist extensor contraction, i.e., without any overt, associated muscle contraction. In the muscle contraction task, subjects performed a self-initiated brief wrist extension. A same pattern of ERD/S was observed in control subjects and parkinsonian patients performing the motor tasks with their less affected limb. In contrast, related to voluntary relaxation performed with the more affected limb, a delayed mu and beta ERD and a disappearance of beta ERS were revealed. These results demonstrate that the pattern of cortical oscillatory activity in a relaxation task is abnormal in parkinsonian patients. The authors suggest that this may be due to anomalous activity in inhibitory motor cortical systems and impaired sensorimotor integration of afferent inputs from muscle and joint receptors.
Split Bregman Iteration Algorithm for Image Deblurring Using Fourth-Order Total Bounded Variation Regularization Model

We propose a fourth-order total bounded variation regularization model which could reduce undesirable effects effectively. Based on this model, we introduce an improved split Bregman iteration algorithm to obtain the optimum solution. The convergence property of our algorithm is provided. Numerical experiments show the more excellent visual quality of the proposed model compared with the second-order total bounded variation model which is proposed by Liu and Huang (2010).
Proviral activation of the c-myb proto-oncogene is detectable in preleukemic mice infected neonatally with Moloney murine leukemia virus but not in resulting end stage T lymphomas

Moloney murine leukemia virus induces myeloid leukemia when inoculated intravenously into pristane-primed adult BALB/c mice. One hundred percent of these tumors show insertional activation of the c-myb proto-oncogene, and reverse transcriptase PCR assays have shown that the c-myb activation could be detected soon after infection. We tested BALB/c and NIH Swiss mice that had been inoculated as newborns with Moloney murine leukemia virus, under which conditions they develop T lymphomas exclusively. Reverse transcriptase-PCR assays indicated that c-myb activations were detectable soon after neonatal infection. However, none of the resulting T lymphomas contained c-myb activations. The implications of these results to the timing of proto-oncogene activations in leukemogenesis and the specificity of proto-oncogene activations for different diseases are discussed.
Acculturative Stress, Psychological Distress, and Religious Coping Among Latina Young Adult Immigrants

Religion is a source of strength in Latina/o culture during challenging life transitions, such as the immigration process. Guided by a sociological stress–process model, this study examines relations between dimensions of religious coping, acculturative stress, and psychological distress among 530 young Latina women (ages 18-23 years) who recently immigrated to the United States (i.e., approximately 12 months prior to assessment). Higher levels of acculturative stress were associated with higher levels of psychological distress. Negative religious coping (i.e., the tendency to struggle with faith) moderated the relation between acculturative stress and psychological distress. Participants experiencing higher levels of acculturative stress reported greater psychological distress when they indicated more negative religious coping. Positive religious coping (i.e., the tendency to relate to faith with comfort and certainty) was not linked with acculturative stress or psychological distress. Implications for culturally tailored counseling interventions for this underserved and understudied population are discussed.
Properties and refinements of the fused lasso

We consider estimating an unknown signal, both blocky and sparse, which is corrupted by additive noise. We study three interrelated least squares procedures and their asymptotic properties. The first procedure is the fused lasso, put forward by Friedman et al. [Ann. Appl. Statist. 1 (2007) 302--332], which we modify into a different estimator, called the fused adaptive lasso, with better properties. The other two estimators we discuss solve least squares problems on sieves; one constrains the maximal $\ell_1$ norm and the maximal total variation seminorm, and the other restricts the number of blocks and the number of nonzero coordinates of the signal. We derive conditions for the recovery of the true block partition and the true sparsity patterns by the fused lasso and the fused adaptive lasso, and we derive convergence rates for the sieve estimators, explicitly in terms of the constraining parameters.
A Missing Link in Understanding Revisit Intention—The Role of Motivation and Image

ABSTRACT This study addresses two gaps in the research on tourist revisit intention: the impact of the pre-visit psychological factor of travel motivation and its relationship with destination image. Path analysis is adopted to examine the relationships among destination image, travel motivation, and revisit intention in a rural tourism context. A causal relationship is detected between three motivation dimensions, two image dimensions, and revisit intention. All three motivational constructs (intellectual, escape, and belonging) exert a significant influence on the cognitive dimension of image, whereas only the motivation construct of escape is significantly related to the affective dimension of image. A causal relationship is also identified between the affective dimension of image and revisit intention.
The Effects of Thyme and Cinnamon Essential Oils on Performance, Rumen Fermentation and Blood Metabolites in Holstein Calves Consuming High Concentrate Diet

Essential oils have been shown to favorably effect in vitro ruminal fermentation, but there are few in vivo studies that have examined animal responses. The objective of this study was to evaluate the effects of thyme (THY) and cinnamon (CIN) essential oils on feed intake, growth performance, ruminal fermentation and blood metabolites in feedlot calves fed high-concentrate diets. Twelve growing Holstein calves (213±17 kg initial BW) were used in a completely randomized design and received their respective dietary treatments for 45 d. Treatments were: 1-control (no additive), 2-THY (5 g/d/calf) and 3-CIN (5 g/d/calf). Calves were fed ad libitum diets consisting of 15% forage and 85% concentrate, and adapted to the finishing diet by gradually increasing the concentrate ratio with feeding a series of transition diets 5 wk before the experiment started. Supplementation of THY or CIN did not affect DMI and ADG, and feed efficiency was similar between treatment groups. There were no effects of additives on ruminal pH and rumen concentrations of ammonia nitrogen and total VFA; whereas molar proportion of acetate and ratio of acetate to propionate decreased, and the molar proportion of propionate increased with THY and CIN supplementation. Rumen molar concentration of butyrate was significantly increased by adding CIN compared to control; but no change was observed with THY compared with control group. No effects of THY, or CIN were observed on valerate, isobutyrate or isovalerate proportions. Plasma concentrations of glucose, cholesterol, triglyceride, urea-N, β-hydroxybutyrate, alanine aminotransferase and aspartate aminotransferase were not changed by feeding THY or CIN. Results from this study suggest that supplementing a feedlot finishing diet with THY or CIN essential oil might be useful as ruminal fermentation modifiers in beef production systems, but has minor impacts on blood metabolites.
Risk factors for anaemia in patients on prolonged linezolid therapy for chronic osteomyelitis: a case-control study.

OBJECTIVES The intrinsic properties of the new antibiotic linezolid make it an attractive candidate for the treatment of chronic osteomyelitis. However, data regarding the tolerance of long-term linezolid administration are still lacking. METHODS The medical charts of patients given linezolid for >4 weeks were retrospectively analysed, especially their haematology. In a case-control study, we compared the respective characteristics of patients who developed anaemia during linezolid therapy and those who did not. RESULTS Forty-five adults with chronic osteomyelitis received 600 mg linezolid intravenously twice daily for 7 days, and then orally, for a mean total duration of 15.9 weeks (range, 6-36). Anaemia episodes requiring blood transfusion occurred in 13/45 patients (28.9%). Median time from treatment initiation to anaemia onset was 7.4 weeks (range, 4-16). Anaemia was significantly associated with premature linezolid therapy cessation (P = 0.0012). No linezolid-related thrombocytopenia was observed. By univariate analysis, four variables were associated with the occurrence of anaemia: age >58 years, alcohol abuse, diabetes mellitus and low haemoglobin before linezolid treatment. Logistic regression analysis revealed two independent risk factors for anaemia: age >58 years (OR = 20.5, 95% CI 0.69-599; P = 0.0001) and pre-treatment haemoglobin <10.5 g/dL (OR = 16.49, 95% CI 1.06-255; P = 0.04). CONCLUSIONS Profound anaemia may occur in adult patients with chronic osteomyelitis on prolonged linezolid therapy, and often necessitates linezolid cessation. These patients are likely to be aged >58 years and to have low pre-treatment haemoglobin. The results for the present series might help physicians to identify patients who should not be given long-term linezolid treatment for chronic osteomyelitis.
How brief is solution focussed brief therapy? a comparative study

Solution Focused Brief Therapy (SFBT) focuses on clients' strengths and expressed goals in an attempt to produce therapeutic change as quickly as possible. This study examined whether clients seen for SFBT were seen for fewer sessions than those seen for cognitive behaviour therapy (CBT) in a clinical psychology service taking adult referrals from primary care. The study was a retrospective one using pseudo-randomization. The results indicated that SFBT clients (n = 41) were seen for two sessions on average compared to five for CBT (n = 119). This difference was accounted for by a higher proportion of the SFBT group being seen for one session only, which is consistent with the approach. A simple therapist-rated outcome scale showed no significant difference between the two groups. Copyright © 2005 John Wiley & Sons, Ltd.
Black girls' perceptions of health and ideal body types

This study employs an opportunity sample of 18 Black girls attending afterschool programmes in a Mid-western US town. The girls were asked to describe health and the ideal body type for girls of their age. Previous research has noted important cultural differences in how girls define both health and their ideal body type, indicating that Black girls in this community may have differing views than other cultural groups. The purpose of this study was to better understand the connections between how Black girls define health, various body types and the ways in which they rationalise their healthy behaviours. According to the girls in this study, health is defined as exercising and eating fruits and vegetables. In addition, the girls mentioned idealising a body type that they referred to as ‘thick’ which is typically larger than Western White ideals. The girls mentioned various sociocultural factors and practices, such as peers and mothers who influence their definitions of the ideal body type. These social influences also impact their social construction of what it means to be healthy. This information can be used to gain an improved understanding of Black girls' perceptions of health and body types to empower them and to expand our understanding and encouragement of various health practices.
Rethinking Sentiment Analysis in the News: from Theory to Practice and back

Most sentiment analysis work has been carried out on highly subjective text types where the target is clearly defined and unique across the text (movie or product reviews). However, when applying sentiment analysis to the news domain, it is necessary to clearly define the scope of the task, in a more specific manner than it has been done in the field so far. The main tasks we identified for news opinion mining are: definition of the target; separation of the good and bad news content from the good and bad sentiment expressed on the target; and analysis of clearly marked opinion that is expressed explicitly, not needing interpretation or the use of world knowledge. It is furthermore important to distinguish three different possible views on newspaper articles - author, reader and text. These have to be addressed differently at the time of analysing sentiment, especially the case of author intention and reader interpretation, where specific profiles must be defined if the proper sentiment is to be extracted.
Effects of Algal Diversity on the Production of Biomass in Homogeneous and Heterogeneous Nutrient Environments: A Microcosm Experiment

Background One of the most common questions addressed by ecologists over the past decade has been-how does species richness impact the production of community biomass? Recent summaries of experiments have shown that species richness tends to enhance the production of biomass across a wide range of trophic groups and ecosystems; however, the biomass of diverse polycultures only rarely exceeds that of the single most productive species in a community (a phenomenon called ‘transgressive overyielding’). Some have hypothesized that the lack of transgressive overyielding is because experiments have generally been performed in overly-simplified, homogeneous environments where species have little opportunity to express the niche differences that lead to ‘complementary’ use of resources that can enhance biomass production. We tested this hypothesis in a laboratory experiment where we manipulated the richness of freshwater algae in homogeneous and heterogeneous nutrient environments. Methodology/Principal Findings Experimental units were comprised of patches containing either homogeneous nutrient ratios (16∶1 nitrogen to phosphorus (N∶P) in all patches) or heterogeneous nutrient ratios (ranging from 4∶1 to 64∶1 N∶P across patches). After allowing 6–10 generations of algal growth, we found that algal species richness had similar impacts on biomass production in both homo- and heterogeneous environments. Although four of the five algal species showed a strong response to nutrient heterogeneity, a single species dominated algal communities in both types of environments. As a result, a ‘selection effect’–where diversity maximizes the chance that a competitively superior species will be included in, and dominate the biomass of a community–was the primary mechanism by which richness influenced biomass in both homo- and heterogeneous environments. Conclusions/Significance Our study suggests that spatial heterogeneity, by itself, is not sufficient to generate strong effects of biodiversity on productivity. Rather, heterogeneity must be coupled with variation in the relative fitness of species across patches in order for spatial niche differentiation to generate complementary resource use.