Miracle-dz/UniFAR-FTUs huggingface dataset:
M-type potassium conductance controls the emergence of neural phase codes: a combined experimental and neuron modelling study

Rate and phase codes are believed to be important in neural information processing. Hippocampal place cells provide a good example where both coding schemes coexist during spatial information processing. Spike rate increases in the place field, whereas spike phase precesses relative to the ongoing theta oscillation. However, what intrinsic mechanism allows for a single neuron to generate spike output patterns that contain both neural codes is unknown. Using dynamic clamp, we simulate an in vivo-like subthreshold dynamics of place cells to in vitro CA1 pyramidal neurons to establish an in vitro model of spike phase precession. Using this in vitro model, we show that membrane potential oscillation (MPO) dynamics is important in the emergence of spike phase codes: blocking the slowly activating, non-inactivating K+ current (IM), which is known to control subthreshold MPO, disrupts MPO and abolishes spike phase precession. We verify the importance of adaptive IM in the generation of phase codes using both an adaptive integrate-and-fire and a Hodgkin–Huxley (HH) neuron model. Especially, using the HH model, we further show that it is the perisomatically located IM with slow activation kinetics that is crucial for the generation of phase codes. These results suggest an important functional role of IM in single neuron computation, where IM serves as an intrinsic mechanism allowing for dual rate and phase coding in single neurons.
Characterization of Eimeria brunetti Isolated from a Poultry Farm in Japan

ABSTRACT None of anticoccidial vaccines (Trivalent TAM™, monovalent Neca™ and imported pentavalent Paracox®-5) contain Eimeria brunetti in Japan, which has not been regarded as a cause of coccidiosis, because of its low prevalence. However, we have recently reported the evidence of a high nationwide prevalence of this species. In this report, we describe the characteristics of E. brunetti which have never been clearly defined in Japan. Mortality rates and other disease characteristics caused by our strain (Nb strain) were similar to those reported previously in other studies. Despite great reduction of body weight gains among groups infected with over 1 × 103 oocysts, the intestinal lesions in the infected chickens were rather mild compared to previous studies. Sulfa drugs and lasalocid were so effective that the E. brunetti infection was almost completely blocked. Consequently, it is suggested that the characteristics of E. brunetti are various among the strains, but the pathogenicity of the Japanese Nb strain is enough strong to cause clinical coccidiosis.
Dynamic Modulation of Amygdala–Hippocampal Connectivity by Emotional Arousal

Positive and negative emotional events are better remembered than neutral events. Studies in animals suggest that this phenomenon depends on the influence of the amygdala upon the hippocampus. In humans, however, it is largely unknown how these two brain structures functionally interact and whether these interactions are similar between positive and negative information. Using dynamic causal modeling of fMRI data in 586 healthy subjects, we show that the strength of the connection from the amygdala to the hippocampus was rapidly and robustly increased during the encoding of both positive and negative pictures in relation to neutral pictures. We also observed an increase in connection strength from the hippocampus to the amygdala, albeit at a smaller scale. These findings indicate that, during encoding, emotionally arousing information leads to a robust increase in effective connectivity from the amygdala to the hippocampus, regardless of its valence.
Implicit time integration for the material point method: Quantitative and algorithmic comparisons with the finite element method

An implicit integration strategy was developed and implemented for use with the material point method (MPM). An incremental‐iterative solution strategy was developed around Newton's method to solve the equations of motion with Newmark integration to update the kinematic variables. Test problems directly compared the implicit MPM solutions with those obtained using an explicit MPM code and implicit finite element (FE) code. Results demonstrated very good agreement with FE predictions and also illustrated several advantages in comparison to calculations using the explicit MPM code. In particular, the accuracy of the implicit solution was superior to the explicit MPM when compared to validated FE solutions, and by definition the implicit time integration is unconditionally stable. Similarities between the assembly of the implicit MPM equations and those of the FE method were identified and should allow further algorithmic improvement. Copyright © 2003 John Wiley & Sons, Ltd.
RSVP: a new resource reservation protocol

This chapter tries to make the general design of RSVP relatively independent of the architectural components. Clearly, a particular implementation of RSVP is tied quite closely to the flowspec and interfaces used by the routing and admission control algorithms. However, the general protocol design should be independent of these. In particular, the protocol should be capable of establishing reservations across networks that implement different routing algorithms, such as IP unicast routing, IP multicast routing, the recently proposed core based tree (CBT) multicast routing, or some future routing protocols. This design goal makes RSVP deployable in many contexts. For optimally efficient routing decisions, however, routing selection and resource reservation should be integrated—so the choice of route can depend on the quality of service requested, and the stability of the route can be maintained over the duration of the reservation. The first RSVP design is verified by a detailed simulation and preliminary implementation. Much testing remains to be done in the context of larger scale simulations, as well as in real prototype networks, such as DARTnet.
Comparative benefits and harms of second generation antidepressants and cognitive behavioral therapies in initial treatment of major depressive disorder: systematic review and meta-analysis

Study question What are the benefits and harms of second generation antidepressants and cognitive behavioral therapies (CBTs) in the initial treatment of a current episode of major depressive disorder in adults? Methods This was a systematic review including qualitative assessment and meta-analyses using random and fixed effects models. Medline, Embase, the Cochrane Library, the Allied and Complementary Medicine Database, PsycINFO, and the Cumulative Index to Nursing and Allied Health Literature were searched from January1990 through January 2015. The 11 randomized controlled trials included compared a second generation antidepressant CBT. Ten trials compared antidepressant monotherapy with CBT alone; three compared antidepressant monotherapy with antidepressant plus CBT. Summary answer and limitations Meta-analyses found no statistically significant difference in effectiveness between second generation antidepressants and CBT for response (risk ratio 0.91, 0.77 to 1.07), remission (0.98, 0.73 to 1.32), or change in 17 item Hamilton Rating Scale for Depression score (weighted mean difference, −0.38, −2.87 to 2.10). Similarly, no significant differences were found in rates of overall study discontinuation (risk ratio 0.90, 0.49 to 1.65) or discontinuation attributable to lack of efficacy (0.40, 0.05 to 2.91). Although more patients treated with a second generation antidepressant than receiving CBT withdrew from studies because of adverse events, the difference was not statistically significant (risk ratio 3.29, 0.42 to 25.72). No conclusions could be drawn about other outcomes because of lack of evidence. Results should be interpreted cautiously given the low strength of evidence for most outcomes. The scope of this review was limited to trials that enrolled adult patients with major depressive disorder and compared a second generation antidepressant with CBT, and many of the included trials had methodological shortcomings that may limit confidence in some of the findings. What this study adds Second generation antidepressants and CBT have evidence bases of benefits and harms in major depressive disorder. Available evidence suggests no difference in treatment effects of second generation antidepressants and CBT, either alone or in combination, although small numbers may preclude detection of small but clinically meaningful differences. Funding, competing interests, data sharing This project was funded under contract from the Agency for Healthcare Research and Quality by the RTI-UNC Evidence-based Practice Center. Detailed methods and additional information are available in the full report, available at http://effectivehealthcare.ahrq. gov/.
Estimating the number of clusters using diversity

It is an important and challenging problem in unsupervised learning to estimate the number of clusters in a dataset. Knowing the number of clusters is a prerequisite for many commonly used clustering algorithms such as \textit{k}-means. In this paper, we propose a novel diversity based approach to this problem. Specifically, we show that the difference between the global diversity of clusters and the sum of each cluster’s local diversity of their members can be used as an effective indicator of the optimality of the number of clusters, where the diversity is measured by Rao’s quadratic entropy. A notable advantage of our proposed method is that it encourages balanced clustering by taking into account both the sizes of clusters and the distances between clusters. In other words, it is less prone to very small “outlier” clusters than existing methods. Our extensive experiments on both synthetic and real-world datasets (with known ground-truth clustering) have demonstrated that our proposed method is robust for clusters of different sizes, variances, and shapes, and it is more accurate than existing methods (including elbow, Calinski-Harabasz, silhouette, and gap-statistic) in terms of finding out the optimal number of clusters.
Interleukin-17A+ cell counts are increased in systemic sclerosis skin and their number is inversely correlated with the extent of skin involvement.

OBJECTIVE Levels of interleukin-17A (IL-17A) have been found to be increased in synovial fluid from individuals with systemic sclerosis (SSc). This study was undertaken to investigate whether IL-17A-producing cells are present in affected SSc skin, and whether IL-17A exerts a role in the transdifferentiation of myofibroblasts. METHODS Skin biopsy samples were obtained from the involved skin of 8 SSc patients and from 8 healthy control donors undergoing plastic surgery. Immunohistochemistry and multicolor immunofluorescence techniques were used to identify and quantify the cell subsets in vivo, including IL-17A+, IL-4+, CD3+, tryptase-positive, α-smooth muscle actin (α-SMA)-positive, myeloperoxidase-positive, and CD1a+ cells. Dermal fibroblast cell lines were generated from all skin biopsy samples, and quantitative polymerase chain reaction, Western blotting, and solid-phase assays were used to quantify α-SMA, type I collagen, and matrix metalloproteinase 1 (MMP-1) production by the cultured fibroblasts. RESULTS IL-17A+ cells were significantly more numerous in SSc skin than in healthy control skin (P = 0.0019) and were observed to be present in both the superficial and deep dermis. Involvement of both T cells and tryptase-positive mast cells in the production of IL-17A was observed. Fibroblasts positive for α-SMA were found adjacent to IL-17A+ cells, but not IL-4+ cells. However, IL-17A did not induce α-SMA expression in cultured fibroblasts. In the presence of IL-17A, the α-SMA expression induced in response to transforming growth factor β was decreased, while MMP-1 production was directly enhanced. Furthermore, the frequency of IL-17A+ cells was higher in the skin of SSc patients with greater severity of skin fibrosis (lower global skin thickness score). CONCLUSION IL-17A+ cells belonging to the innate and adaptive immune system are numerous in SSc skin. IL-17A participates in inflammation while exerting an inhibitory activity on myofibroblast transdifferentiation. These findings are consistent with the notion that IL-17A has a direct negative-regulatory role in the development of dermal fibrosis in humans.
Wireless Communication in Data Centers: A Survey

Data centers (DCs) is becoming increasingly an integral part of the computing infrastructures of most enterprises. Therefore, the concept of DC networks (DCNs) is receiving an increased attention in the network research community. Most DCNs deployed today can be classified as wired DCNs as copper and optical fiber cables are used for intra- and inter-rack connections in the network. Despite recent advances, wired DCNs face two inevitable problems; cabling complexity and hotspots. To address these problems, recent research works suggest the incorporation of wireless communication technology into DCNs. Wireless links can be used to either augment conventional wired DCNs, or to realize a pure wireless DCN. As the design spectrum of DCs broadens, so does the need for a clear classification to differentiate various design options. In this paper, we analyze the free space optical (FSO) communication and the 60 GHz radio frequency (RF), the two key candidate technologies for implementing wireless links in DCNs. We present a generic classification scheme that can be used to classify current and future DCNs based on the communication technology used in the network. The proposed classification is then used to review and summarize major research in this area. We also discuss open questions and future research directions in the area of wireless DCs.
Socioeconomic Indicators of Bamboo Use for Agroforestry Development in the Dry Semi-Deciduous Forest Zone of Ghana

Bamboo agroforestry is currently being promoted in Ghana as a viable land use option to reduce dependence on natural forest for wood fuels. To align the design and introduction of bamboo agroforestry to the needs of farmers, information on the determinants of bamboo acceptability and adoption is necessary. It is, therefore, the aim of this study to determine how socioeconomic factors, local farming practices and local knowledge on bamboo may influence its acceptability and adoption as a component of local farming systems. Data were collected from 200 farmers in the dry semi-deciduous forest zone of Ghana using semi-structured questionnaire interviews. The results show that farmers’ traditional knowledge on bamboo including its use for charcoal production and leaves for fodder are influential determinants of bamboo adoption. Among the demographic characteristics of farmers, age and gender are the most significant predictors. It is also evident that the regular practice of leaving trees on farmlands and type of cropping system may influence bamboo integration into traditional farming systems.
Navigational Efficiency of Nocturnal Myrmecia Ants Suffers at Low Light Levels

Insects face the challenge of navigating to specific goals in both bright sun-lit and dim-lit environments. Both diurnal and nocturnal insects use quite similar navigation strategies. This is despite the signal-to-noise ratio of the navigational cues being poor at low light conditions. To better understand the evolution of nocturnal life, we investigated the navigational efficiency of a nocturnal ant, Myrmecia pyriformis, at different light levels. Workers of M. pyriformis leave the nest individually in a narrow light-window in the evening twilight to forage on nest-specific Eucalyptus trees. The majority of foragers return to the nest in the morning twilight, while few attempt to return to the nest throughout the night. We found that as light levels dropped, ants paused for longer, walked more slowly, the success in finding the nest reduced and their paths became less straight. We found that in both bright and dark conditions ants relied predominantly on visual landmark information for navigation and that landmark guidance became less reliable at low light conditions. It is perhaps due to the poor navigational efficiency at low light levels that the majority of foragers restrict navigational tasks to the twilight periods, where sufficient navigational information is still available.
Eating Habits and Lifestyles among a Sample of Obese Working Egyptian Women

BACKGROUND: The fundamental cause of obesity and overweight is an energy imbalance between calories consumed and calories expended. AIM: To figure out food habits and different lifestyle pattern among a sample of Egyptian females working at the National Research Centre. METHODS: A cross-sectional, descriptive study, including 138 overweight and obese Egyptian females (BMI ≥ 25 Kg/m2); working at the National Research Centre; was done. A specific questionnaire was used to gather information regarding lifestyle including dietary habits, physical activity and sedentary behaviour. RESULTS: The prevalence of overweight among the studied subjects was 27%, while that of obesity was 38%. Missing and or infrequent intake of breakfast at home, frequent consumption of snacks, low serving per day of fruits and vegetables with frequent consumption of sweets, fried food, eating while watching TV and sedentary behaviour were all predictors of obesity and overweight among the current sample. CONCLUSION: The present study identified several lifestyle factors and improper dietary habits associated with overweight and obesity among Egyptian females. There is a great need to change these habits to avoid the increasing risk of obesity. A national plan of action to overcome obesity is urgently needed to reduce its economic and health burden.
Diabetic Peripheral Neuropathy Compromises Balance During Daily Activities

OBJECTIVE Patients with diabetes with peripheral neuropathy have a well-recognized increased risk of falls that may result in hospitalization. Therefore this study aimed to assess balance during the dynamic daily activities of walking on level ground and stair negotiation, where falls are most likely to occur. RESEARCH DESIGN AND METHODS Gait analysis during level walking and stair negotiation was performed in 22 patients with diabetic neuropathy (DPN), 39 patients with diabetes without neuropathy (D), and 28 nondiabetic control subjects (C) using a motion analysis system and embedded force plates in a staircase and level walkway. Balance was assessed by measuring the separation between the body center of mass and center of pressure during level walking, stair ascent, and stair descent. RESULTS DPN patients demonstrated greater (P < 0.05) maximum and range of separations of their center of mass from their center of pressure in the medial-lateral plane during stair descent, stair ascent, and level walking compared with the C group, as well as increased (P < 0.05) mean separation during level walking and stair ascent. The same group also demonstrated greater (P < 0.05) maximum anterior separations (toward the staircase) during stair ascent. No differences were observed in D patients. CONCLUSIONS Greater separations of the center of mass from the center of pressure present a greater challenge to balance. Therefore, the higher medial-lateral separations found in patients with DPN will require greater muscular demands to control upright posture. This may contribute to explaining why patients with DPN are more likely to fall, with the higher separations placing them at a higher risk of experiencing a sideways fall than nondiabetic control subjects.
Nanometer-Thin Pure Boron Layers as Mask for Silicon Micromachining

The properties of nanometer-thin pure boron layers deposited by chemical vapor deposition were investigated for use as a barrier against tetramethyl ammonium hydroxide (TMAH) and potassium hydroxide (KOH) etching of Si. Deposition temperatures of 400 °C and 700 °C were applied to form layers of a few nanometer thick. Down to 2-nm thickness, they were all found to be resistant to these wet Si etchants. Patterning of the layers was achieved with resist masking and standard aluminum wet-etchant. The selectivity to Si was extremely high, much greater than 10<sup>4</sup>. Cavities <inline-formula> <tex-math notation="LaTeX">$70~\mu \text{m}$ </tex-math></inline-formula> deep were etched without measurable etching of the boron layers, and with <inline-formula> <tex-math notation="LaTeX">$\langle 100\rangle /\langle 111\rangle $ </tex-math></inline-formula> etch-rate ratios of about 35 for TMAH and larger than 50 for KOH. Stress levels were measured to be 490 MPa tensile for 400 °C and 1250 MPa compressive for 700 °C deposition. Hundreds of micron wide membranes that remained intact were fabricated. [2017-0175]
Midterm results of percutaneous closure of very large atrial septal defects in children: role of multislice computed tomography.

AIMS The aim of this study was to assess the midterm results of percutaneous closure of very large atrial septal defects (ASD) in children with transthoracic echocardiography (TTE) and multislice computed tomography (MSCT). METHODS AND RESULTS Among 142 children who underwent percutaneous ASD closure with the AMPLATZER® Septal Occluder (ASO) (AGA Medical Corporation, Plymouth, MN, USA) during an eight year period, 51 patients with very large defects, were evaluated by TTE and MSCT after a period of at least two years following ASD closure. Median age at ASD closure was six years (range 4-10), with mean ASD size 20.9±2.9 mm. Median device size was 20 mm (range 15-26) and median device: septal length ratio 0.95 (range 0.8-1). Early complications included one transient complete atrioventricular block and one device embolisation. At a median follow-up of 55 months (range 25-92) all patients were clinically asymptomatic and had a normal ECG. TTE did not demonstrate device protrusion across the lumen of either the systemic or pulmonary veins. The mean device: septal length ratio had decreased from 0.96±0.05 to 0.8±0.02 (p<0.001). There was good correlation between the measure of atrial septum length by TTE and MSCT (r: 0.79, p<0.001). MSCT identified moderate dynamic device protrusion into the lumen of systemic or pulmonary veins in five patients and partial device malpositioning in two patients. CONCLUSIONS Occlusion of very large ASD in children can be performed with low complications rate. MSCT provides detailed information regarding the location of the device with respect to surrounding anatomic structures and reveals anomalies not evident by TTE.
Optimized photolithographic fabrication process for carbon nanotube devices

We have developed a photolithographic process for the fabrication of large arrays of single walled carbon nanotube transistors with high quality electronic properties that rival those of transistors fabricated by electron beam lithography. A buffer layer is used to prevent direct contact between the nanotube and the novolac-based photoresist, and a cleaning bake at 300C effectively removes residues that bind to the nanotube sidewall during processing. In situ electrical measurement of a nanotube transistor during a temperature ramp reveals sharp decreases in the ON-state resistance that we associate with the vaporization of components of the photoresist. Data from nearly 2000 measured nanotube transistors show an average ON-state resistance of 250 ± 100 kΩ. This new process represents significant progress towards the goal of high-yield production of large arrays of nanotube transistors for applications including chemical sensors and transducers, as well as integrated circuit components.