Miracle-dz/UniFAR-FTUs huggingface dataset:
Milling Curves Influence in Ring Rolling Processes

Ring Rolling is a complex hot forming process used for the production of shaped rings, seamless and axis symmetrical workpieces. The main advantage of workpieces produced by ring rolling, compared to other technological processes, is given by the size and orientation of grains, especially on the worked surface which give to the final product excellent mechanical properties. In this process different rolls (Idle, Axial, Guide and Driver) are involved in generating the desired ring shape. Since each roll is characterized by a speed law that can be set independently by the speed law imposed to the other rolls, an optimization is more critical compared with other deformation processes. Usually, in industrial environment, a milling curve is introduced in order to correlate the Idle and Axial roll displacement, however it must be underlined that different milling curves lead to different loads and energy for ring realization. In this work an industrial case study was modeled by a numerical approach: different milling curves characterized by different Idle and Axial roll speed laws (linearly decreasing, constant, linearly increasing) were designed and simulated. The results were compared in order to identify the best milling curve that guarantees a good quality ring (higher diameter, lower fishtail) with lower loads and energy required for manufacturing.
Mastery matters most: How mastery and positive relations link attachment avoidance and anxiety to negative emotions

Attachment avoidance and anxiety are associated with negative emotions. However, the mechanisms underlying these associations are not fully understood. We investigated environmental mastery and positive relations with others as two mechanisms behind the attachment–emotion link in a sample of 343 adults. As predicted, attachment avoidance and anxiety were related to greater fear, hostility, envy and depression through lower mastery. Contrary to our hypothesis, positive relations mediated only the attachment–depression link. In addition, by adopting a moderated mediation approach, we were able to show that mastery mattered most for individuals high on avoidance: The indirect effect of avoidance through lack of mastery on fear, hostility and depression (but not on envy) increased with higher avoidance scores. Contrary to our predictions, poor relationships did not matter more as sources of negative emotions as anxiety increased. These findings underscore that the emotional life of avoidantly attached individuals is especially jeopardised by poor mastery.
A validation study of ultrasonic foetal weight estimation models for Hong Kong Chinese singleton pregnancies.

OBJECTIVE To validate the published regression models for ultrasonic foetal weight estimation in Hong Kong Chinese singleton pregnancies. DESIGN Prospective cohort study. SETTING Regional hospital, Hong Kong. PARTICIPANTS One hundred and fourteen Hong Kong Chinese women with singleton pregnancy at term (37-42 weeks). MAIN OUTCOME MEASURES The birth weight of the neonate was used to validate the ultrasonic foetal weight estimation models. The ultrasound used to collect the data was performed within 2 days prior to delivery. RESULTS Foetal weight estimation models published by Hadlock and Woo have a high intraclass correlation coefficient of 0.86. Woo's regression model has the least mean difference (0.2 g; 95% limits of agreement, -569.4 to 569.8 g) and Hadlock 3 has the smallest limits of agreement (-114.6 g; 95% limits of agreement, -663.4 to 434.2 g) among the models tested. CONCLUSIONS Woo's regression model of foetal weight estimation gave the least mean difference and the actual birth weight for our local population were within the acceptable limits of agreement.
Comparison between the abuse assessment screen and the revised conflict tactics scales for measuring physical violence during pregnancy

Study objective: Because of the promise of its ability to quickly identify cases of violence against women during pregnancy, the abuse assessment screen (AAS) should be the focus of numerous psychometric evaluations. This paper assesses its measurement accuracy compared with the revised conflict tactics scales (CTS2) used as standard. Design: Cross sectional study. Besides several ancillary questions, the AAS consists of three anchor questions about violence against pregnant women. These are inclusive, respectively covering lifetime, preceding 12 months, and pregnancy periods. These questions are the main focus of this article. The CTS2 physical aggression scale consists of 12 items divided into minor and severe subscales. A positive event is defined as having at least one positive item in the respective subscale. The 12 item score is also used. Setting and participants: The instruments were applied to 748 women, 24 to 72 hours after delivery in three major public sector maternity wards of Rio de Janeiro from March to September 2000. Main results: According to the CTS2, prevalences of minor and severe physical violence perpetrated against a pregnant woman are 18.4% (95% CI 15.7 to 21.4) and 7.6% (95% CI 5.8 to 9.8), respectively. Taking these subscales as standards, sensitivities are 31.9% (95% CI 24.9 to 40.3) and 61.4% (95% CI 47.6 to 74.0), respectively. Specificities are above 97%. Conclusion: These findings are somewhat worrying because the number of victims who are not identified and offered assistance is considerable. On a practical note, it would be sensible not to use the AAS as a stand alone screening tool until more evidence is gathered.
Effects of Echinocandins in Combination with Nikkomycin Z against Invasive Candida albicans Bloodstream Isolates and the fks Mutants

ABSTRACT We evaluated the in vitro and in vivo effects of nikkomycin Z combined with an echinocandin (anidulafungin or micafungin) against two Candida albicans isolates and their lab-derived echinocandin-resistant fks mutants with FKS1 S645Y and FKS1 S645P. Synergistic effects were observed in all tested strains (fractional inhibitory concentration index, <0.5). Enhanced survival was observed in an immunocompromised murine model (log-rank test, P < 0.02). Our study demonstrated the therapeutic potential of nikkomycin Z-echinocandin combinations in managing echinocandin resistance.
Randomized, Double-Blind Trial of an Antibiotic-Lock Technique for Prevention of Gram-Positive Central Venous Catheter-Related Infection in Neutropenic Patients with Cancer

ABSTRACT The aim of the present study was to determine the efficacy of an antibiotic-lock technique in preventing endoluminal catheter-related infection with gram-positive bacteria in neutropenic patients with hematologic malignancies. Patients with nontunneled, multilumen central venous catheters were assigned in a randomized, double-blinded manner to receive either 10 U of heparin per ml (57 patients) or 10 U of heparin per ml and 25 μg of vancomycin per ml (60 patients), which were instilled in the catheter lumen and which were allowed to dwell in the catheter lumen for 1 h every 2 days. Insertion-site and hub swabs were taken twice weekly. The primary and secondary end points of the trial were significant colonization of the catheter hub and catheter-related bacteremia, respectively. Significant colonization of the catheter hub occurred in nine (15.8%) patients receiving heparin (seven patients were colonized with Staphylococcus epidermidis, one patient was colonized with Staphylococcus capitis, and one patient was colonized withCorynebacterium sp.), whereas the catheter hubs of none of the patients receiving heparin and vancomycin were colonized (P = 0.001). Catheter-related bacteremia developed in four (7%) patients receiving heparin (three patients had S. epidermidis bacteremia and one patient had S. capitisbacteremia), whereas none of the patients in the heparin and vancomycin group had catheter-related bacteremia (P = 0.05). The times to catheter hub colonization and to catheter-related bacteremia by the Kaplan-Meier method were longer in patients receiving heparin and vancomycin than in patients receiving heparin alone (P = 0.004 and P = 0.06, respectively). Our study shows that a solution containing heparin and vancomycin administered by using an antibiotic-lock technique effectively prevents catheter hub colonization with gram-positive bacteria and subsequent bacteremia during chemotherapy-induced neutropenia in patients with hematologic malignancy.
Semantic and episodic memory in children with temporal lobe epilepsy: do they relate to literacy skills?

OBJECTIVE Children with temporal lobe epilepsy are at risk for deficits in new learning (episodic memory) and literacy skills. Semantic memory deficits and double dissociations between episodic and semantic memory have recently been found in this patient population. In the current study we investigate whether impairments of these 2 distinct memory systems relate to literacy skills. METHOD 57 children with unilateral temporal lobe epilepsy completed tests of verbal memory (episodic and semantic) and literacy skills (reading and spelling accuracy, and reading comprehension). RESULTS For the entire group, semantic memory explained over 30% of variance in each of the literacy domains. Episodic memory explained a significant, but rather small proportion (< 10%) of variance in reading and spelling accuracy, but not in reading comprehension. Moreover, when children with opposite patterns of specific memory impairments (intact semantic/impaired episodic, intact episodic/impaired semantic) were compared, significant reductions in literacy skills were evident only in children with semantic memory impairments, but not in children with episodic memory impairments relative to the norms and to children with temporal lobe epilepsy who had intact memory. CONCLUSIONS Our study provides the first evidence for differential relations between episodic and semantic memory impairments and literacy skills in children with temporal lobe epilepsy. As such, it highlights the urgent need to consider semantic memory deficits in management of children with temporal lobe epilepsy and undertake further research into the nature of reading difficulties of children with semantic memory impairments.
Origins of the midlatitude Pacific decadal variability

Analysis of multiple climate simulations shows much of the midlatitude Pacific decadal variability to be composed of two simultaneously occurring elements: One is a stochastically driven, passive ocean response to the atmosphere while the other is oscillatory and represents a coupled mode of the ocean‐atmosphere system. ENSO processes are not required to explain the origins of the decadal variability. The stochastic variability is driven by random variations in wind stress and heat flux associated with internal atmospheric variability but amplified by a factor of 2 by interactions with the ocean. We also found a coupled mode of the ocean‐atmosphere system, characterized by a significant power spectral peak near 1 cycle/20 years in the region of the midlatitude North Pacific and Kuroshio Extension. Ocean dynamics appear to play a critical role in this coupled air/sea mode.
Cerebral oxygenation declines in healthy elderly subjects in response to assuming the upright position.

BACKGROUND AND PURPOSE With increasing age, assuming the upright position is more often accompanied by symptoms such as dizziness and lightheadedness, possibly as a result of a diminished oxygen supply to the brain due to impaired cerebral autoregulation. We aimed to quantify postural changes in cerebral oxygenation and systemic hemodynamics in healthy elderly and young subjects. METHODS In 18 healthy elderly subjects (aged 70 to 83 years) and 10 healthy young subjects (aged 22 to 45 years), frontal cortical oxygenation and hemodynamic responses were continuously monitored by near infrared spectroscopy and Finapres, respectively, before and during 10 minutes of active standing. RESULTS -Cortical oxyhemoglobin concentration [O(2)Hb] decreased by -4.6+/-2.2 micromol/L (P<0.001) and cortical deoxyhemoglobin concentration increased by 1.5+/-2.4 micromol/L (P<0.05) in the elderly subjects after posture change, whereas these variables did not change significantly in the young subjects. The postural hemodynamic changes tended to be attenuated in the elderly subjects, except for the increases in systolic blood pressure (BP). Smaller postural increases in diastolic BP were related to larger [O(2)Hb] decreases (r=0.53, P<0.01, corrected for the age effect). CONCLUSIONS Assuming the upright position evokes an asymptomatic decrease in frontal cortical oxygenation in healthy elderly subjects but not in healthy young subjects. Cortical [O(2)Hb] changes are affected by diastolic BP changes. These findings may indicate that regulation of cerebral oxygenation alters with increasing age.
Matricellular Proteins: A Sticky Affair with Cancers

The multistep process of metastasis is a major hallmark of cancer progression involving the cointeraction and coevolution of the tumor and its microenvironment. In the tumor microenvironment, tumor cells and the surrounding stromal cells aberrantly secrete matricellular proteins, which are a family of nonstructural proteins in the extracellular matrix (ECM) that exert regulatory roles via a variety of molecular mechanisms. Matricellular proteins provide signals that support tumorigenic activities characteristic of the metastastic cascade such as epithelial-to-mesenchymal (EMT) transition, angiogenesis, tumor cell motility, proliferation, invasion, evasion from immune surveillance, and survival of anoikis. Herein, we review the current understanding of the following matricellular proteins and highlight their pivotal and multifacted roles in metastatic progression: angiopoietin-like protein 4 (ANGPTL4), CCN family members cysteine-rich angiogenic inducer 61 (Cyr61/CCN1) and CCN6, osteopontin (OPN), secreted protein acidic and rich in cysteine (SPARC), tenascin C (TNC), and thrombospondin-1 and -2 (TSP1, TSP2). Insights into the signaling mechanisms resulting from the interaction of these matricellular proteins and their respective molecular partner(s), as well as their subsequent contribution to tumor metastasis, are discussed. In addition, emerging evidences of their promising potential as therapeutic options and/or targets in the treatment of cancer are also highlighted.
Undergraduate Nurses’ and Midwives’ Participation and Satisfaction with Live Interactive Webcasts

Introduction: E-Learning methods such as webcasting are being used increasingly in healthcare education, including that of nurses and midwives. Webcasting means live synchronous broadcasting over the internet, where students participate simultaneously in text ‘chat room’ interactive discussions when logged on to a webpage where they can see and hear a presentation such as a PowerPoint lecture, a list of other participants, and access ‘chat rooms’. Aims: This paper reports student participation and satisfaction with the use of webcasting in a third year undergraduate nursing and midwifery research methods module in one higher education institution faculty of health and social work in the southwest of England, with students from distributed geographical locations. Materials and Methods: Students chose either webcasts or face-to-face lectures. Following each of the four webcasts, a web-based evaluation questionnaire was administered in a cross-sectional survey design. Results: Two thirds of students took part in webcasts and found them to be an acceptable teaching and learning strategy. Travel and cost savings were noted through not travelling to the main university campus, and these were statistically significantly correlated with students’ perception of gaining from the module and their overall satisfaction with webcasting. Across the four webcasts 5446 purposeful messages were posted indicating engagement with the material under study. Conclusions and Recommendations: Webcasting is an effective teaching and learning strategy which is popular with students, allows remote access to teaching and learning, and offers time and cost savings to students. Further research is required to investigate the educational potential of this new technology.
Dexmedetomidine and Neurocognitive Testing in Awake Craniotomy

Patients are selected for awake craniotomy when the planned procedure involves eloquent areas of the brain, necessitating an awake, cooperative patient capable of undergoing neurocognitive testing. Different anesthetic combinations, including neurolept, propofol with or without opioid infusions, and asleep-awake-asleep techniques, have been reported for awake craniotomy. In all these techniques, respiratory depression has been reported as a complication. In this case series dexmedetomidine, the highly selective alpha-2 adrenoreceptor agonist, was selected for its lack of respiratory depression as well as its sedative and analgesic properties. The charts of 10 consecutive patients who underwent awake craniotomy with dexmedetomidine infusion were reviewed. Five of the patients underwent “asleep-awake” technique with a laryngeal mask airway and volatile agent. Five patients received moderate to conscious sedation. All patients received a dexmedetomidine load of 0.5 to 1.0 &mgr;g/kg over 20 minutes followed by an infusion at rates of 0.01 to 1.0 &mgr;g/kg per hour. Four patients had extensive sensory and motor testing, and six underwent neurocognitive testing, including naming, reading, counting, and verbal fluency. There were no permanent neurologic deficits, except one patient who had an exacerbation of preoperative language difficulties. Dexmedetomidine appears to be a useful sedative for awake craniotomy when sophisticated neurologic testing is required.
An Ensemble Technique for Stable Learners with Performance Bounds

Ensemble techniques such as bagging and DECORATE exploit the "instability" of learners, such as decision trees, to create a diverse set of models. However, creating a diverse set of models for stable learners such as naive Bayes is difficult as they are relatively insensitive to training data changes. Furthermore, many popular ensemble techniques do not have a rigorous underlying theory and often provide no insight into how many models to build. We formally define stable learner as having a second order derivative of the posterior density function and propose an ensemble technique specifically for stable learners. Our ensemble technique, bootstrap model averaging, creates a number of bootstrap samples from the training data, builds a model from each and then sums the joint instance and class probability over all models built. We show that for stable learners our ensemble technique for infinite bootstrap samples approximates posterior model averaging (aka the optimal Bayes classifier (OBC)). For finite bootstrap samples we estimate the increase over the aBC error using Chebychev bounds. We empirically illustrate our approach's usefulness for several stable learners and verify our bound's correctness.
O-Minimal Cohomology: Finiteness and invariance Results

The topology of definable sets in an o-minimal expansion of a group is not fully understood due to the lack of a triangulation theorem. Despite the general validity of the cell decomposition theorem, we do not know whether any definably compact set is a definable CW-complex. Moreover the closure of an o-minimal cell can have arbitrarily high Betti numbers. Nevertheless we prove that the cohomology groups of a definably compact set over an o-minimal expansion of a group are finitely generated and invariant under elementary extensions and expansions of the language.
Analyzing Term Weighting Schemes for Labeling Software Clusters

Clustering techniques have been widely employed for software modularization. The clusters formed as a result of the clustering process may be difficult to understand unless they are appropriately labeled. One method to assign labels is to use term weighting schemes from Information Retrieval and Text Categorization which use weights to assign importance to terms in a document. Some of these term weighting schemes have been used by researchers for labeling clusters, but there is a need to compare various schemes and analyze their strengths and weaknesses. In this paper, we analyze four different schemes in the context of software and identify cases where one may be better than the other. We also conduct experiments to verify the behavior of the weighting schemes according to software characteristics.
Capacity enhancement of cognitive wireless networks with 7-distance spectrum usage policy

How much information can one transmit over a randomly distributed ad hoc network of n secondary devices, overlaid with m primary devices? Such a network model is referred to as cognitive wireless network (CWN) and our paper addresses the above question by characterizing its throughput capacity. Although a handful of research efforts related to throughput capacity exist in the area of CWNs, most of these solutions under-explore the capacity analysis. Their analysis particularly indicates that secondary devices can realize only a less or no gain on throughput capacity, in comparison to classical ad hoc networks, when the primary devices are densely placed in the network. Our detailed investigation shows that this unsatisfying capacity figure is due to the unrealistic assumptions and inefficient allocation of wireless spectrum for secondary devices, while formulating the capacity analysis. By resolving the issues in existing research efforts, we enhance the throughput capacity of secondary devices in CWN and at the heart of our analysis lies a novel spectrum usage policy known as γ-distance spectrum usage policy for secondary devices. In contrast to classical ad hoc networks, our results stipulate that when primary devices are densely placed in the network with an i.i. d inactive period of Poff, cognitive wireless network can realize an aggregate throughput capacity of W Poffγ√(m)off/γ √(n/log n) under the constraint Poffγ√(m)off/γ >; 1. This is in fact an interesting result which claims that by judiciously allocating the traffic of secondary devices in the licensed and unlicensed spectrum bands, one can enhance the throughput capacity of cognitive wireless networks.
FokI Polymorphism in the Vitamin D Receptor Gene (VDR) and Its Association with Lumbar Spine Pathologies in the Italian Population: A Case-Control Study

Alterations in vitamin D homeostasis, mainly involving its nuclear receptor (VDR), could have a role in the pathophysiology of the spine. The association between VDR polymorphisms and spine disorders has been analyzed in different ethnic groups, focusing on the functional FokI polymorphism. However, so far, inconsistent findings were reported. The aims of this study were to evaluate, in the Italian white population, the VDR FokI polymorphism frequencies distribution in subjects with clearly defined lumbar spinal pathologies compared to asymptomatic controls and to analyze the interplay of genetic and conventional risk factors. Using a case-control design, 267 patients with spinal disorders and 220 asymptomatic controls were enrolled, evaluating their exposition to putative risk factors. Patients’ clinical assessment was performed by Magnetic Resonance Imaging. FokI polymorphism (rs2228570) was detected by PCR-RFLP. Genotypes were designated by a lowercase letter (f allele, T nucleotide) for the presence of the restriction site and by a capital letter (F allele, C nucleotide) for its absence. Family history, higher age and BMI, exposure to vibration, physical job demand, smoking habit and lower practice of leisure physical activity were associated with spinal disorders. The FF genotype and F allele represented approximately 2-fold risk factors to develop discopathies and/or osteochondrosis concomitant with disc herniation, while f allele was protective. In conclusion, the link we observed between VDR FokI variants and specific lumbar spine pathologies suggests that spinal tissue degeneration is influenced by the genetic background. Future studies should evaluate the signaling pathways involving alterations in VDR and influencing the development and/or progression of spine disorders.