Miracle-dz/UniFAR-FTUs huggingface dataset:
Incidence of Venous Thromboembolism Using 64 Channel Multidetector Row Computed Tomography-Indirect Venography and Anti-Coagulation Therapy after Total Knee Arthroplasty in Korea

Purpose This study evaluated the incidence of a venous thromboembolism (VTE) after total knee arthroplasty (TKA) using multidetector row computed tomography-indirect venography (MDCT-indirect venography) and assessed the efficacy of anti-coagulation therapy. Materials and Methods We enrolled 118 patients with 126 cases of TKA. The average age of the patients was 68.4 years. We used 64 channel MDCT-indirect venography for the detection of VTE. We treated selectively proximal deep vein thrombosis (DVT) or pulmonary thromboembolism (PTE) cases according to the results of MDCT-indirect venography. We re-evaluated the change in VTE using follow-up MDCT-indirect venography after 3 months. Results We identified VTE in 35.7%. DVT only was identified in 22.2% including 8 cases of proximal DVT and 20 cases of distal DVT. PTE without DVT was identified in 4.8%, and combined DVT and PTE in 8.7%. All patients with PTE were asymptomatic, but 4 DVT patients had signs of leg swelling. After anti-coagulation therapy, 20 patients showed complete resolution in 16 cases, improvement in 3 cases and one case showed a new distal DVT. Conclusions The incidence of VTE after primary TKA was 35.7% in Korea. Furthermore, anti-coagulation therapy for proximal DVT and PTE patients may be a useful method for preventing the occurrence of a fatal PTE.
WILD BEE ABUNDANCE AND SEED PRODUCTION IN CONVENTIONAL, ORGANIC, AND GENETICALLY MODIFIED CANOLA

The ecological impacts of agriculture are of concern, especially with genetically modified and other intensive, modern cropping systems, yet little is known about effects on wild bee populations and subsequent implications for pollination. Pollination deficit (the difference between potential and actual pollination) and bee abundance were measured in organic, conventional, and herbicide-resistant, genetically modified (GM) canola fields (Brassica napus and B. rapa) in northern Alberta, Canada, in the summer of 2002. Bee abundance data were collected using pan traps and standardized sweep netting, and pollination deficit was assessed by comparing the number of seeds per fruit from open-pollinated and supplementally pollinated flowers. There was no pollination deficit in organic fields, a moderate pollination deficit in conventional fields, and the greatest pollination deficit in GM fields. Bee abundance was greatest in organic fields, followed by conventional fields, and lowest in GM fields. Overall, there.
Modified Distributive Arithmetic Based DWT-IDWT Processor Design and FPGA Implementation for Image Compression

: One of the major image processing techniques that is widely used in medical, automotive, consumer and military applications is image compression. Discrete wavelet transforms is the most popular transformation technique adopted for image compression. Complexity of DWT is always high due to large number of arithmetic operations. In this work a modified Distributive Arithmetic based DWT architecture is proposed and is implemented on FPGA. The modified approach consumes area of 6% on Spartan-III pro FPGA and operates at 134 MHz. The modified DA-DWT architecture has a latency of 44 clock cycles and a throughput of 4 clock cycles. This design is twice faster than the reference design and is thus suitable for applications that require high speed image processing algorithms.
Father-child play, child emotional dysregulation, and adolescent internalizing symptoms: A longitudinal multiple mediation analysis

Abstract Emerging literature suggests fathers may contribute uniquely to child development and emotional health through play. In the present study, a multiple mediational model was analyzed using data from 476 families that participated in the NICHD Study of Early Child Care and Youth Development. After accounting for infant–mother attachment, infant temperament, and family income and stability, a significant indirect effect from father–child play quality to adolescent internalizing symptoms was found through father-reported child emotional dysregulation, B = –. 05, 95% confidence interval; CI [–. 14, –. 01]. Specifically, in first grade, dyads where fathers were rated highly on sensitivity and stimulation during play, and children demonstrated high felt security and affective mutuality during play, had children with fewer father-reported emotional dysregulation problems in third grade, B = –. 23, 95% CI [–. 39, –. 06]. Children with fewer emotional dysregulation problems had lower self-reported internalizing symptoms at age 15, B = . 23, 95% CI [. 01, . 45]. Mothers’ ratings of children's emotional dysregulation were not a significant mediator. Results are discussed regarding the importance of father–child play for children's adjustment as well as the usefulness of inclusion of fathers in child developmental research.
Raeppli: a whole-tissue labeling tool for live imaging of Drosophila development

Observation of how cells divide, grow, migrate and form different parts of a developing organism is crucial for understanding developmental programs. Here, we describe a multicolor imaging tool named Raeppli (after the colorful confetti used at the carnival in Basel). Raeppli allows whole-tissue labeling such that the descendants of the majority of cells in a single organ are labeled and can be followed simultaneously relative to one another. We tested the use of Raeppli in the Drosophila melanogaster wing imaginal disc. Induction of Raeppli during larval stages irreversibly labels >90% of the cells with one of four spectrally separable, bright fluorescent proteins with low bias of selection. To understand the global growth characteristics of imaginal discs better, we induced Raeppli at various stages of development, imaged multiple fixed discs at the end of their larval development and estimated the size of their pouch primordium at those developmental stages. We also imaged the same wing disc through the larval cuticle at different stages of its development; the clones marked by Raeppli provide landmarks that can be correlated between multiple time points. Finally, we used Raeppli for continuous live imaging of prepupal eversion of the wing disc.
Forward stagewise regression and the monotone lasso

We consider the least angle regression and forward stagewise algorithms for solving penalized least squares regression problems. In Efron, Hastie, Johnstone & Tibshirani (2004) it is proved that the least angle regression algorithm, with a small modification, solves the lasso regression problem. Here we give an analogous result for incremental forward stagewise regression, showing that it solves a version of the lasso problem that enforces monotonicity. One consequence of this is as follows: while lasso makes optimal progress in terms of reducing the residual sum-of-squares per unit increase in $L_1$-norm of the coefficient $\beta$, forward stage-wise is optimal per unit $L_1$ arc-length traveled along the coefficient path. We also study a condition under which the coefficient paths of the lasso are monotone, and hence the different algorithms coincide. Finally, we compare the lasso and forward stagewise procedures in a simulation study involving a large number of correlated predictors.
Study of Serum Leptin in Polytransfused Children with Beta Thalassemia Major

Background: thalassemic patients with frequent blood transfusion can result in iron overload and increase serum ferritine level. Leptin is a polypeptide hormone that is mainly expressed in bone marrow and adipocytes and previous studies consumed that it is lower in thalassemic patients compared to healthy children as a result of hemsedrosis. Objectives: The aim of this study was to evaluate leptin serum levels in patients with β- thalassemia major. Patients and methods: This case-control study was conducted on 50 children from 13 to 17 years old, at Al-Azhar university Hospitals (Sayed Galal & Al-Hussien hospitals). They were subdivided in two groups 30 patients (s- thalassemia major) and 20 as control that were matched in age and sex. All Children were examined to be free from heart disease , iron deficiency anemia, kidney disease, diabetes, fever and systemic diseases were enrolled after taking informed consent of their parents. After collecting the samples, leptin and ferritin levels of the serum were measured in two groups by ELISA method. Then, the data were analyzed by the related statistical tests and SPSS 20 software. Results: The mean of the serum levels of leptin and ferritin showed a significant difference in the case and control groups (P-value < 0.05). Levels of leptin in the case group showed no significant gender difference (P-value < 0.05). Conclusion: Based on the results of this study, thalassemia major reduces serum levels of leptin regardless of age and body mass.
Metabolic syndrome, insulin resistance and sleepiness in real-life obstructive sleep apnoea

The metabolic syndrome shows a variable prevalence in obstructive sleep apnoea (OSA), and its association with insulin resistance or excessive daytime sleepiness in OSA is unclear. This study assessed the following in consecutive patients with newly diagnosed OSA: 1) the prevalence of metabolic syndrome; and 2) its association with insulin resistance and daytime sleepiness. Metabolic syndrome (National Cholesterol Education Program Adult Treatment Panel (NCEP-ATP) III criteria), insulin resistance (Homeostatic Model Assessment (HOMA) index, n=288) and daytime sleepiness (Epworth Sleepiness Scale) were assessed in 529 OSA patients. The prevalence of metabolic syndrome was 51.2%, which increased with OSA severity. Each metabolic syndrome component correlated with apnoea/hypopnoea index, but only blood pressure retained significance after correction for confounders. Both obesity and OSA contributed to metabolic abnormalities, with different sex-related patterns, since diagnosis of metabolic syndrome was significantly associated with neck circumference, age, body mass index and lowest arterial oxygen saturation in males, and with age and arousal index in females. The number of metabolic syndrome components increased with HOMA index (p<0.001). Prevalence of sleepiness was the same in patients with and without metabolic syndrome. The metabolic syndrome occurs in about half of “real-life” OSA patients, irrespective of daytime sleepiness, and is a reliable marker of insulin resistance.
THE DETERMINANTS OF ACTUARIAL ASSUMPTIONS UNDER PENSION ACCOUNTING DISCLOSURES

Corporate managers make several assumptions such as the discount rate and the rate of salary progression in calculating the periodic pension expense and pension liabilities. The choice of these assumptions can pose significant problems for financial reporting. This paper examines the following two questions concerning the choice of these assumptions. First, what factors drive these assumptions? and second, are these assumptions dependent on each other? Based on a sample of 300 observations, we find that leverage and pension plan funding play important roles in the choice of these assumptions. More importantly, it appears that these choices are related. The results of our study have important implications for analysts and accounting standard setters.
TPM analyses reveal that FtsK contributes both to the assembly and the activation of the XerCD-dif recombination synapse

Circular chromosomes can form dimers during replication and failure to resolve those into monomers prevents chromosome segregation, which leads to cell death. Dimer resolution is catalysed by a highly conserved site-specific recombination system, called XerCD-dif in Escherichia coli. Recombination is activated by the DNA translocase FtsK, which is associated with the division septum, and is thought to contribute to the assembly of the XerCD-dif synapse. In our study, direct observation of the assembly of the XerCD-dif synapse, which had previously eluded other methods, was made possible by the use of Tethered Particle Motion, a single molecule approach. We show that XerC, XerD and two dif sites suffice for the assembly of XerCD-dif synapses in absence of FtsK, but lead to inactive XerCD-dif synapses. We also show that the presence of the γ domain of FtsK increases the rate of synapse formation and convert them into active synapses where recombination occurs. Our results represent the first direct observation of the formation of the XerCD-dif recombination synapse and its activation by FtsK.
Severe receptive language disorder in childhood—familial aspects and long-term outcomes: results from a Scottish study

Background and aims: Little is known about the familial characteristics of children with severe receptive specific language impairment (SLI). Affected children are more likely to have long-term problems than those with expressive SLI but to date they have only been described as small cohorts within SLI populations. We therefore aimed to describe the clinical and familial characteristics of severe receptive SLI as defined by a rigorous phenotype and to establish whether non-word repetition showed a relationship with language impairment in these families. Methods: Cross-sectional study of children who met ICD-10 (F80.2) criteria for receptive SLI at school entry, their siblings and genetic parents with standardised measures of language and non-verbal IQ, phonological auditory memory and speech sound inventory. Results: At a mean of 6 years after school entry with a severe receptive SLI, the 58 participants had a normal mean and standard deviation non-verbal IQ, but only 3% (two) had attained language measures in the normal range. One third still had severe receptive language impairment. One third of siblings not known to be affected had language levels outside the normal range. Phonological auditory memory was impaired in most family members. Conclusion: Severe receptive SLI is nearly always associated with an equally severe reduction in expressive language skills. Language impairment in siblings may go undetected and yet they are at high risk. Family members had weak phonological auditory memory skills, suggesting that this could be a marker for language acquisition difficulties. Receptive SLI rarely resolves and trials of therapy are urgently needed.
Inner and outer congruence: An academic’s quest to find spiritual wellness and health

ABSTRACT This article explores the role a meditative practice might play in enhancing the spiritual wellness and health of staff within higher education contexts. Drawing on her own reflective writings about her meditation practice, as well literature from spirituality in higher education, meditation, and adult learning, the author considers how one works toward leading a life of congruence; a life where meaning and purpose are tightly interwoven with intellect and action, and where compassion and care are infused with insight and knowledge.
Stimulating angiogenesis mitigates the unloading-induced reduction in osteogenesis in early-stage bone repair in rats

Accelerating fracture healing during bed rest allows early mobilization and avoids prolonged fracture healing times. We tested the hypothesis that stimulating angiogenesis with deferoxamine (DFO) mitigates the unloading‐induced reduction in early‐stage bone repair. Rats aged 12 weeks were subjected to cortical drilling on their tibial diaphysis under anesthesia and treated with hindlimb unloading (HU), HU and DFO administration (DFOHU), or weight bearing (WB) for 5 or 10 days (HU5/10, DFOHU5/10, WB5/10; n = 8 per groups) until sacrifice for vascular casting with a zirconium dioxide‐based contrast agent. Taking advantage of its absorption discontinuity at the K‐absorption edge, vascular and bone images in the drill‐hole defects were acquired by synchrotron radiation subtraction CT. Bone repair was reduced in HU rats. The bone volume fraction (B.Vf) was 88% smaller in HU5 and 42% smaller in HU10 than in WB5/10. The bone segment densities (B.Seg) were 97% smaller in HU5 and 141% larger in HU10 than in WB5/10, and bone thickness (B.Th) was 38% smaller in HU10 than in WB10. The vascular volume fraction (V.Vf) was 35% and the mean vessel diameter (V.D) was 13% smaller in HU10 than in WB10. When compared according to categorized vessel sizes, V.Vf in the diameter ranges 20–30, 30–40, and >40 μm were smaller in HU10 than in WB10, and V.Seg in the diameter range >40 μm was smaller in HU10 than in WB10. In contrast, there was no difference in B.Vf between DFOHU5/10 and WB5/10 and in V.Vf between DFOHU10 and WB10, though B.Seg remained 86% smaller in DFOHU5 and 94% larger in DFOHU10 than in WB5/10, and B.Th and V.D were 23% and 14% lower in DFOHU10 than in WB10. Vessel size‐specific V.Vf in the diameter ranges 10–20 and 20–30 μm was larger in DFOHU5 than in HU5. In conclusion, the enhanced angiogenic ingrowth mitigates the reduction in bone repair during mechanical unloading.
Emission-line diagnostics of low-metallicity active galactic nuclei

Current emission-line-based estimates of the metallicity of active galactic nuclei (AGN) at both high and low redshifts indicate that AGN have predominantly solar-to-supersolar metallicities. This leads to the question: do low-metallicity AGN exist? In this paper, we use photoionization models to examine the effects of metallicity variations on the narrow emission-lines from an AGN. We explore a variety of emission-line diagnostics that are useful for identifying AGN with low-metallicity gas. We find that line ratios involving [N II] are the most robust metallicity indicators in galaxies where the primary source of ionization is from the active nucleus. Ratios involving [S II] and [O I] are strongly affected by uncertainties in modelling the density structure of the narrow-line clouds. To test our diagnostics, we turn to an analysis of AGN in the Sloan Digital Sky Survey (SDSS). We find a clear trend in the relative strength of [N II] with the mass of the AGN-host galaxy. The metallicity of the ISM is known to be correlated with stellar mass in star-forming galaxies; our results indicate that a similar trend exists for AGN. We also find that the best-fitting models for typical Seyfert narrow-line regions (NLRs) have supersolar abundances. Although there is a mass-dependent range of a factor of 2‐3 in the NLR metallicities of the AGN in our sample, AGN with subsolar metallicities are very rare in the SDSS. Out of a sample of ∼23 000 Seyfert 2 galaxies, we find only ∼40 clear candidates for AGN with NLR abundances that are below solar.
Typology and Universals

1. Introduction 2. Typological classification 3. Implicational universals 4. Markedness in typology 5. Grammatical hierarchies 6. Prototypes and the interaction of typological patterns 7. External motives and the typology of form-function relations 8. Diachronic typology 9. Linguistic explanation in the dynamic paradigm Notes References Map of languages cited Author index Language index Subject index.
α-Crystallin distribution in retinal pigment epithelium and effect of gene knockouts on sensitivity to oxidative stress

Purpose To investigate the susceptibility of retinal pigment epithelium (RPE) from αA (-/-) and αB (-/-) mice to oxidative stress, and the subcellular changes of αA and αB-crystallins under oxidative stress. Methods The effect of hydrogen peroxide (H2O2) on apoptosis in RPE from αA (-/-), αB (-/-), and wild type (wt) mice was assessed by TUNEL and AnnexinV/Propidium Iodide assays. H2O2-induced changes in caspase-3 activity and mitochondrial permeability transition (MPT) were determined. Human RPE in early passages (2-4) were starved in 1% FBS-containing Dulbecco's modified Eagle medium (DMEM) and treated with H2O2 for 24 h. Gene expression was quantitated by real time PCR. Confocal microscopy was used to examine α-crystallin compartmentalization. Whole cell and mitochondrial α-crystallin protein amounts were examined by transmission electron microscopy (TEM) and Western blot analysis. Results RPE from αA (-/-), αB (-/-) mice exhibited increased susceptibility to apoptosis induced by H2O2, increased caspase-3 activation, and increased MPT. Treatment of human RPE with H2O2 resulted in a dose-dependent decrease in αB-crystallin mRNA expression. Confocal microscopy and subcellular fractionation of RPE showed that H2O2 treatment decreased cytosolic and mitochondrial pools of αB-crystallin but caused no change in αA-crystallin content. TEM confirmed changes in expression of αA and αB-crystallins with oxidative stress. Conclusions Lack of α-crystallins renders RPE cells more susceptible to apoptosis from oxidative stress. Mitochondrial α-crystallins may play an important role in the protection from increased susceptibility of RPE in oxidative stress.
Arcobacter butzleri: Underestimated Enteropathogen

Molecular methods applied to 2,855 strains of Campylobacter-like organisms received from a surveillance network of Campylobacter infections in France identified 29 Arcobacter butzleri infections. This species ranks fourth for Campylobacteraceae isolation and appears to have the same pathogenic potential as the other species in the genus.
DIC Score in Pregnant Women – A Population Based Modification of the International Society on Thrombosis and Hemostasis Score

Objectives The objectives of this study were: 1) To determine the component needed to generate a validated DIC score during pregnancy. 2) To validate such scoring system in the identification of patients with clinical diagnosis of DIC. Material and Methods This is a population based retrospective study, including all women who gave birth at the ‘Soroka University Medical Center’ during the study period, and have had blood coagulation tests including complete blood cell count, prothrombin time (PT)(seconds), partial thromboplastin time (aPTT), fibrinogen, and D-dimers. Nomograms for pregnancy were established, and DIC score was constructed based on ROC curve analyses. Results 1) maternal plasma fibrinogen concentrations increased during pregnancy; 2) maternal platelet count decreased gradually during gestation; 3) the PT and PTT values did not change with advancing gestation; 4) PT difference had an area under the curve (AUC) of 0.96 (p<0.001), and a PT difference ≥1.55 had an 87% sensitivity and 90% specificity for the diagnosis of DIC; 5) the platelet count had an AUC of 0.87 (p<0.001), an 86% sensitivity and 71% specificity for the diagnosis of DIC; 6) fibrinogen concentrations had an AUC of 0.95 (p<0.001) and a cutoff point ≤3.9 g/L had a sensitivity of 87% and a specificity of 92% for the development of DIC; and 7) The pregnancy adjusted DIC score had an AUC of 0.975 (p<0.001) and at a cutoff point of ≥26 had a sensitivity of 88%, a specificity of 96%, a LR(+) of 22 and a LR(−) of 0.125 for the diagnosis of DIC. Conclusion We could establish a sensitive and specific pregnancy adjusted DIC score. The positive likelihood ratio of this score suggests that a patient with a score of ≥26 has a high probability to have DIC.
Success Factors of Agribusiness Digital Marketplaces

Abstract Digital marketplaces are market institutions that employ digital information technology – computers, the Internet, and the World Wide Web – to provide trading services to buyers and sellers. We trace the development of agribusiness digital marketplaces on the World Wide Web and use observations taken from a sample of 233 agribusiness digital marketplaces to assess the impact of marketplace characteristics on market success. We measure success in terms of qualitative and quantitative indicators. Characteristics of marketplaces that could be expected to reduce transaction costs were identified. The impact of the selected characteristics on success was estimated using logistic and conventional linear regression analysis. Key success factors found are market liquidity, an international orientation, and concentration on providing exchange services as the core business of the DMP.