Miracle-dz/UniFAR-FTUs huggingface dataset:
Clinical evaluation of the newly formatted lateral‐flow device for invasive pulmonary aspergillosis

The study evaluated the newly formatted Aspergillus‐specific lateral‐flow‐device (LFD), and compared its performance to the original prototype “old” LFD test using BALF samples from 28 patients (14 patients with probable/proven invasive pulmonary aspergillosis [IPA] and 14 patients with no evidence for IPA). A total of 10/14 (71%) of BALF samples from patients with probable/proven IPA resulted positive with the new LFD, including 8/9 with true‐positive and 2/5 with false‐negative results with the old LFD. All 14 samples from patients without IPA resulted negative with the new LFD; specificity of the new LFD was significantly improved compared to the old LFD.
Factors Influencing the Behavioural Intention to Adopt Internet Banking: An Empirical Study in India

Internet banking provides huge benefits to banks in cost savings, improved customer relationships and differentiating their offerings from competitors. Although the Internet banking services were introduced in India for more than a decade ago, the adoption among the bank customers is still very low. This study aims to identify the factors that are significantly influencing the bank customers intention to use Internet banking services in India. The research proposed a comprehensive model called "Internet banking Acceptance in India", constructs of which were developed based partially on the Unified Theory of Acceptance and Use of Technology (UTAUT) and three additional variables as identified to be context-specific. The data presented in this study are based on 325 questionnaires collected from individual bank customers in Hyderabad city. The empirical findings of the study confirms the relationships between the identified latent variables and their impact on the adoption of Internet banking services. The proposed model explained about 67% of the variance in behavioural intention to adopt the Internet banking in India. This study contributes to the literature by providing a new research framework for predicting Internet banking adoption in India and its findings provide useful insights for bank managers and policy makers in planning Internet banking promotion strategies.
Nurses' Experience of Adjusting to Workplace Violence: a Theory of Adaptation

Workplace violence directed at nurses working in both the mental health and general areas of the hospital is a common occurrence and the impact of these events on all parties may be severe. A consequence of these confronting situations is the possibility that nurse victims will leave the profession. To help administrators facilitate nurses' psychological recovery, this qualitative study identified how nurses in several areas of a hospital setting adapted to workplace violence, research which has been previously unexamined. This study was the first of its kind to use a theory of cognitive adaptation to explore nurses' experiences of workplace violence. Participants were found to use the cognitive processes of finding meaning, gaining mastery and enhancing the self to adapt to workplace violence. Critical incident debriefing may facilitate the nurse victim's psychological recovery following an episode of workplace violence.
The growth performance of the progeny of two swine sire lines reared under different floor space allowances.

A total of 736 pigs was used in a study with a 2 x 2 x 2 factorial arrangement to investigate the effects of and interactions between sire line (Line A vs. B), floor space (unrestricted vs. restricted), and gender (barrow vs. gilt) on growth performance, BW, and protein and estimated lipid accretion curves from 40 to 120 kg of BW. Pigs were by eight Line-A and nine Line-B sires mated with PIC C22 dams. Line A was of Pietrain ancestry and Line B was a synthetic line. The unrestricted floor space treatment consisted of small groups (four pigs) with 0.93 m2/pig of floor space for the entire grow-finish period. Pigs in the restricted floor space were in larger groups (12 pigs) with 0.37 and 0.56 m2/pig of floor space for the grower and finisher phases, respectively. Pigs were given ad libitum access to a three-phase dietary program, and one and three nipple waterers were available in the groups of 4 and 12 pigs, respectively. No sire line x floor space interactions were found for any of the traits measured. Line A pigs grew more slowly (50 g/d, P < 0.05), took longer (4.1 d, P < 0.05) to reach harvest weight (120.3 kg), and had similar feed intakes, but a lower gain:feed ratio (2.8%, P < 0.05) than Line B pigs. Line A pigs had greater longissimus muscle depth (P < 0.05) and estimated protein accretion rate (P < 0.05) than Line B pigs, but Line A and Line B pigs had a similar estimated percentage of lipid-free soft tissue. Pigs reared in the restricted floor space grew more slowly (105 g/d, P < 0.05) and consumed less feed (280 g/d, P < 0.05) but had a similar (P > 0.05) gain:feed ratio to pigs reared in the unrestricted floor space. Pigs reared in the unrestricted floor space had greater (P < 0.05) predicted protein and lipid accretion rates throughout the growth period than pigs reared in the restricted floor space. Differences between genders for growth traits and carcass measurements were in agreement with previous research. The differences in growth performance, carcass measures, and compositional growth curves between these two sire lines were similar in the two floor spaces.
Integrated investigation of dementia risk factors : insights from geography, record linkage, and individual participant meta-analysis

Objective: Individual cardiovascular disease (CVD) risk factors are associated with dementia. For the first time, we investigated whether the Framingham CVD risk scoreewhich comprises these multiple risk factorsewas also associated with future dementia risk. Methods: Individual participant meta-analysis of two large, general population cohort studies (N 1⁄4 11,887). For the purposes of comparison of the dementia results, we also examined the association between the Framingham CVD risk score and CVD-related death. Results: Framingham CVD risk score was associated with dementia death (hazard ratio per 10% increased risk, 95% confidence interval: 4.00, 2.44e6.56). Adjusting for age eliminated this association (1.04, 0.53e2.01); similarly, age explained 88% of the ability of the Framingham CVD risk score to predict CVD death. Conclusions: The Framingham CVD risk score was no more strongly associated with future dementia than age. It therefore offers no added value in predicting dementia. 2013 Elsevier Ireland Ltd. All rights reserved.
MODELLING THE SLOW EMOTIONAL STROOP EFFECT: SUPPRESSION OF COGNITIVE CONTROL

Our connectionist model provides a theoretical explanation for the existence of slow and fast emotional Stroop effects, and depicts them as independent but interacting phenomena. We build upon previous modelling work by Cohen et a] (1990) and Botvinick et al (2001) among others, and incorporate data that suggest a functional division of the Anterior Cingulate Cortex (ACC) into Cognitive and Affective Divisions. This work suggests that slow emotional Stroop effects are caused by activation of the affective portion of the ACC, which inhibits the Cognitive division, reducing top-down cognitive control on the subsequent trial.
Identification of MicroRNA 395a in 24-Epibrassinolide-Regulated Root Growth of Arabidopsis thaliana Using MicroRNA Arrays

Brassinosteroids (BRs) are endogenous plant hormones and are essential for normal plant growth and development. MicroRNAs (miRNAs) of Arabidopsis thaliana are involved in mediating cell proliferation in leaves, stress tolerance, and root development. The specifics of BR mechanisms involving miRNAs are unknown. Using customized miRNA array analysis, we identified miRNAs from A. thaliana ecotype Columbia (Col-0) regulated by 24-epibrassinolide (EBR, a highly active BR). We found that miR395a was significantly up-regulated by EBR treatment and validated its expression under these conditions. miR395a was over expressed in leaf veins and root tissues in EBR-treated miR395a promoter::GUS plants. We integrated bioinformatics methods and publicly available DNA microarray data to predict potential targets of miR395a. GUN5—a multifunctional protein involved in plant metabolic functions such as chlorophyll synthesis and the abscisic acid (ABA) pathway—was identified as a possible target. ABI4 and ABI5, both genes positively regulated by ABA, were down-regulated by EBR treatment. In summary, our results suggest that EBR regulates seedling development and root growth of A. thaliana through miR395a by suppressing GUN5 expression and its downstream signal transduction.
Mercury content in shark species from the South-Eastern Brazilian coast.

We present here the first results of Hg concentrations in three small shark species (Rhizoprionodon lalandei, R. porosus and Mustelus higmani) from the SE Brazilian coast. Mercury concentrations in R. lalandei ranged from 21.5 to 280.0 ng.g-1 dry weight (d.w.) (average 74.6 ng.g-1 d.w.; 17.9 ng.g-1 wet weight). In R. porosus, concentrations ranged from 7.6 to 90.5 ng.g-1 d.w. (average 42.2 ng.g-1 d.w., 9.4 ng.g-1 wet weight), whereas in M. higmani, concentrations ranged from 13.0 to 162.8 ng.g-1 d.w. (average 54.9 ng.g-1 d.w., 13.4 ng.g-1 wet weight). These concentration ranges are very low compared with values reported for other large shark species of the Southwestern Atlantic Ocean. There was a significant positive correlation between Hg concentrations and individual size, suggesting that biomagnification is occurring in these animals.
Continuous liquid interface production of 3D objects

Fast, continuous, 3D printing Although three-dimensional (3D) printing is now possible using relatively small and low-cost machines, it is still a fairly slow process. This is because 3D printers require a series of steps to cure, replenish, and reposition themselves for each additive cycle. Tumbleston et al. devised a process to effectively grow solid structures out of a liquid bath. The key to the process is the creation of an oxygen-containing “dead zone” between the solid part and the liquid precursor where solidification cannot occur. The precursor liquid is then renewed by the upward movement of the growing solid part. This approach made structures tens of centimeters in size that could contain features with a resolution below 100 µm. Science, this issue p. 1349 Solid parts are elevated from a liquid resin pool at a speed of hundreds of millimeters per hour. Additive manufacturing processes such as 3D printing use time-consuming, stepwise layer-by-layer approaches to object fabrication. We demonstrate the continuous generation of monolithic polymeric parts up to tens of centimeters in size with feature resolution below 100 micrometers. Continuous liquid interface production is achieved with an oxygen-permeable window below the ultraviolet image projection plane, which creates a “dead zone” (persistent liquid interface) where photopolymerization is inhibited between the window and the polymerizing part. We delineate critical control parameters and show that complex solid parts can be drawn out of the resin at rates of hundreds of millimeters per hour. These print speeds allow parts to be produced in minutes instead of hours.
Risk-sensitive benchmarked asset management

This paper extends the risk-sensitive asset management theory developed by Bielecki and Pliska and by Kuroda and Nagai to the case where the investor's objective is to outperform an investment benchmark. The main result is a mutual fund theorem. Every investor following the same benchmark will take positions, in proportions dependent on his/her risk sensitivity coefficient, in two funds: the log-optimal portfolio and a second fund which adjusts for the correlation between the traded assets, the benchmark and the underlying valuation factors.
Microsporidia Infection of the Cornea—A Unique and Challenging Disease

Abstract: Microsporidia are a diverse group of obligate, intracellular, eukaryotic, spore-forming parasites. Traditionally, these were considered as protozoans but recently have been reclassified as fungi. Microsporidia behave as opportunistic pathogens causing systemic infections. In the eye, Microsporidia cause keratoconjunctivitis, corneal stromal keratitis, scleritis, and endophthalmitis. This review shares our experiences with anterior segment infections caused by this pathogen. Keratoconjunctivitis is a common form of ocular infection caused by the parasite. Although early reports described it as occurring only in immunosuppressed individuals, it can also occur in immunocompetent individuals. The disease shows a seasonal pattern with a peak incidence during the rainy season. Although several drugs have been considered, our experience suggests that keratoconjunctivitis is a self-limiting disease. In contrast to keratoconjunctivitis, stromal keratitis is an ill-defined disease. We collected 30 cases and analyzed the various aspects of this disease. Stromal keratitis is characterized by a slowly progressive course. The corneal picture resembles herpes simplex virus stromal keratitis or fungal keratitis cases, and is characterized by deep stromal infiltrates with overlying and surrounding stromal edema and keratic precipitates. The diagnosis of Microsporidia infection is confirmed by a microscopic examination of smears from patients with ulcerative keratitis or by a histopathological examination of corneal tissues. Definitive genus identification requires the examination of specimens by electron microscopy or by molecular methods. In the absence of a definitive medical treatment, nearly all patients require surgical treatment. The confusion regarding Microsporidia is not only limited to their classification but also extends to various aspects of the corneal disease caused by them.
Coming events cast their shadows before: detecting inflammation in the acute diabetic foot and the foot in remission

The incidence of diabetic foot complications, most notably wounds, is increasing worldwide. Most people who present for care of a foot wound will become infected. Globally, this results in one major amputation every 30 seconds with over 2500 limbs lost per day. Presently, clinicians assess circulation, neuropathy and plantar pressures to identify the risk of foot ulceration. Several studies have suggested prevention of foot ulcers by identifying individuals at high risk and treating for lower extremity complications. Our group has proposed several diagnostics as well as prevention strategies, especially thermography and thermometry for management of patients with diabetic foot complications. These strategies employ non‐invasive assessment of inflammation for acute as well as chronic care for the foot, with the intent to prevent ulceration/re‐ulceration and subsequent traumatic amputations. The authors' review some important clinical studies and ongoing research in this area, with the long‐term goal to further the role of thermography and thermometry in clinical care for the diabetic foot. Copyright © 2012 John Wiley & Sons, Ltd.
6-Bromoisatin Found in Muricid Mollusc Extracts Inhibits Colon Cancer Cell Proliferation and Induces Apoptosis, Preventing Early Stage Tumor Formation in a Colorectal Cancer Rodent Model

Muricid molluscs are a natural source of brominated isatin with anticancer activity. The aim of this study was to examine the safety and efficacy of synthetic 6-bromoisatin for reducing the risk of early stage colorectal tumor formation. The purity of 6-bromoisatin was confirmed by 1H NMR spectroscopy, then tested for in vitro and in vivo anticancer activity. A mouse model for colorectal cancer was utilized whereby colonic apoptosis and cell proliferation was measured 6 h after azoxymethane treatment by hematoxylin and immunohistochemical staining. Liver enzymes and other biochemistry parameters were measured in plasma and haematological assessment of the blood was conducted to assess potential toxic side-effects. 6-Bromoisatin inhibited proliferation of HT29 cells at IC50 223 μM (0.05 mg/mL) and induced apoptosis without increasing caspase 3/7 activity. In vivo 6-bromoisatin (0.05 mg/g) was found to significantly enhance the apoptotic index (p ≤ 0.001) and reduced cell proliferation (p ≤ 0.01) in the distal colon. There were no significant effects on mouse body weight, liver enzymes, biochemical factors or blood cells. However, 6-bromoisatin caused a decrease in the plasma level of potassium, suggesting a diuretic effect. In conclusion this study supports 6-bromoisatin in Muricidae extracts as a promising lead for prevention of colorectal cancer.
Chicken, egg, or a bit of both? : motivation in bilingual education (TTO) in The Netherlands

Conducted within the context of the general academic secondary school track in the Netherlands (HAVO), this study sought to investigate motivational differences between learners in bilingual (TTO) and in Dutch-language education (NTO). TTO being by now a well- established educational route, certain stereotypes and assumptions exist with regard to the type of learner it attracts. One of these assumptions is that TTO learners are particularly motivated to learn, although lack of previous research in this area means that there is little evidence to confirm that this is the case. As a bilingual approach to education that draws much of its inspiration from Content and Language Integrated Learning (CLIL), and considering recent emphasis on contextual factors and the learning environment in (L2) motivation studies, it might also be assumed that the TTO learning context could have a motivating effect among learners. Again, however, there is little evidence regarding the motivational impact of teaching and learning in TTO specifically. This two-phase study employed a range of methods, from inclusive research using discussions and online forums, to quantitative data collection using learner questionnaires. These were administered to approximately 800 learners in the first three years of HAVO, across four schools. TTO learners appeared to display more characteristics that aligned with various theories of general and language-learning motivation. The most prominent of these characteristics were the integrative motive, a sense of agency, and future self-guides. The motivation of NTO learners appeared less strong, but may also develop differently to that of TTO learners. There was little evidence to suggest that learners’ experience of the TTO learning environment contributed significantly to the maintenance or development of these motivational characteristics, although it may have the potential to do so. Recommendations were made for how both learner-groups might be supported by schools in optimising their individual motivations.
Altered Inflammatory Response Is Associated With an Impaired Autonomic Input to the Bone Marrow in the Spontaneously Hypertensive Rat

Autonomic nervous system dysfunction, exaggerated inflammation, and impaired vascular repair are all hallmarks of hypertension. Considering that bone marrow (BM) is a major source of the inflammatory cells (ICs) and endothelial progenitor cells (EPCs), we hypothesized that impaired BM–autonomic nervous system interaction contributes to dysfunctional BM activity in hypertension. In the spontaneously hypertensive rat (SHR), we observed a >30% increase in BM and blood ICs (CD4.8+) and a >50% decrease in EPCs (CD90+.CD4.5.8–) when compared with the normotensive Wistar–Kyoto rat. Increased tyrosine hydroxylase (70%) and norepinephrine (160%) and decreased choline acetyl transferase (30%) and acetylcholine esterase (55%) indicated imbalanced autonomic nervous system in SHR BM. In Wistar–Kyoto rat, night time–associated elevation in sympathetic nerve activity (50%) and BM norepinephrine (41%) was associated with increased ICs (50%) and decreased EPCs (350%) although BM sympathetic denervation decreased ICs (25%) and increased EPCs (40%). In contrast, these effects were blunted in SHR, possibly because of chronic downregulation of BM adrenergic receptor &agr;2a (by 50%–80%) and &bgr;2 (30%–45%). Application of norepinephrine resulted in increased BM IC activation/release, which was prevented by preadministration of acetylcholine. Electrophysiological recordings of femoral sympathetic nerve activity showed a more robust femoral sympathetic nerve activity in SHR when compared with Wistar–Kyoto rat, peaking earlier in the respiratory cycle, indicative of increased sympathetic tone. Finally, manganese-enhanced MRI demonstrated that presympathetic neuronal activation in SHR was associated with an accelerated retrograde transport of the green fluorescent protein–labeled pseudorabies virus from the BM. These observations demonstrate that a dysfunctional BM autonomic nervous system is associated with imbalanced EPCs and ICs in hypertension.
The Truncated C-terminal Fragment of Mutant ATXN3 Disrupts Mitochondria Dynamics in Spinocerebellar Ataxia Type 3 Models

Spinocerebellar ataxia type 3 (SCA3), known as Machado-Joseph disease, is an autosomal dominant disease caused by an abnormal expansion of polyglutamine in ATXN3 gene, leading to neurodegeneration in SCA3 patients. Similar to other neurodegenerative diseases, the dysfunction of mitochondria is observed to cause neuronal death in SCA3 patients. Based on previous studies, proteolytic cleavage of mutant ATXN3 is found to produce truncated C-terminal fragments in SCA3 models. However, whether these truncated mutant fragments disturb mitochondrial functions and result in pathological death is still unclear. Here, we used neuroblastoma cell and transgenic mouse models to examine the effects of truncated mutant ATXN3 on mitochondria functions. In different models, we observed truncated mutant ATXN3 accelerated the formation of aggregates, which translocated into the nucleus to form intranuclear aggregates. In addition, truncated mutant ATXN3 caused more mitochondrial fission, and decreased the expression of mitochondrial fusion markers, including Mfn-1 and Mfn-2. Furthermore, truncated mutant ATXN3 decreased the mitochondrial membrane potential, increased reactive oxygen species and finally increased cell death rate. In transgenic mouse models, truncated mutant ATXN3 also led to more mitochondrial dysfunction, neurodegeneration and cell death in the cerebellums. This study supports the toxic fragment hypothesis in SCA3, and also provides evidence that truncated mutant ATXN3 is severer than full-length mutant one in vitro and in vivo.
Robust Transmission of H.264/AVC Video using Adaptive Slice Grouping and Unequal Error Protection

We present a novel scheme for the transmission of H.264/AVC video streams over lossy packet networks. The proposed scheme exploits the error resilient features of H.264/AVC codec and employs Reed-Solomon codes to protect effectively the streams. The optimal classification of macroblocks into slice groups and the optimal channel rate allocation are achieved by iterating two interdependent steps. Simulations clearly demonstrate the superiority of the proposed method over other recent algorithms for transmission of H.264/AVC streams