Miracle-dz/UniFAR-FTUs huggingface dataset:
RAB7 counteracts PI3K-driven macropinocytosis activated at early stages of melanoma development

Derailed endolysosomal trafficking is emerging as a widespread feature of aggressive neoplasms. However, the oncogenic signals that alter membrane homeostasis and their specific contribution to cancer progression remain unclear. Understanding the upstream drivers and downstream regulators of aberrant vesicular trafficking is distinctly important in melanoma. This disease is notorious for its inter- and intra-tumoral heterogeneity. Nevertheless, melanomas uniformly overexpress a cluster of endolysosomal genes, being particularly addicted to the membrane traffic regulator RAB7. Still, the underlying mechanisms and temporal determinants of this dependency have yet to be defined. Here we addressed these questions by combining electron microscopy, real time imaging and mechanistic analyses of vesicular trafficking in normal and malignant human melanocytic cells. This strategy revealed Class I PI3K as the key trigger of a hyperactive influx of macropinosomes that melanoma cells counteract via RAB7-mediated lysosomal degradation. In addition, gain- and loss-of-function in vitro studies followed by histopathological validation in clinical biopsies and genetically-engineered mouse models, traced back the requirement of RAB7 to the suppression of premature cellular senescence traits elicited in melanocytes by PI3K-inducing oncogenes. Together, these results provide new insight into the regulators and modes of action of RAB7, broadening the impact of endosomal fitness on melanoma development.
Apical sparing in tako‐tsubo cardiomyopathy

Background: Tako‐tsubo cardiomyopathy (TTC) is an acute reversible cause of segmental myocardial dysfunction that is poorly understood. We have noted a variant of this condition where a tiny segment at the apex retains some contractile function. This paper delineates the frequency of this variant relative to the classical form and the clinical differences between patients suffering from the two forms.
El Equipo Directivo «E-Competente» y su Liderazgo en el Proceso de Integración de las TIC en los Centros Educativos

El liderazgo existente en los centros educativo es uno de los factores mas importantes en el proceso de integracion de las tecnologias de la informacion y la comunicacion (TIC). Este trabajo contribuye a la comprension de como la cultura organizativa de un centro educativo influye en el proceso de introduccion y utilizacion de las TIC. Se analiza la relevancia del papel del equipo directivo y de su liderazgo en el desarrollo de dicho proceso. Para ello, se ha utilizado un diseno de investigacion basado en un Estudio de Caso Multiple en tres momentos diferentes, desde un enfoque de Teoria Fundamentada. Se ha identificado una tipologia de equipo directivo «e-competente» que se caracteriza principalmente por su fuerte liderazgo pedagogico, transformacional y distribuido, ademas de su motivacion en desarrollar medidas y estrategias para fomentar la integracion de las TIC. En este sentido, se ha comprobado que el liderazgo del equipo directivo es un factor clave en la promocion de la innovacion educativa, sobre todo, en la integracion de las TIC en sus colegios, pues influye en la organizacion y la toma de decisiones, actuando como catalizador y facilitador de dicho proceso. Palabras clave: Integracion de las TIC, Organizacion escolar, Equipo directivo, Liderazgo pedagogico, Liderazgo transformacional, Liderazgo distribuido, Competencia digital. One of the most important factors in the process of integrating ICT has to do with the existing leadership in schools. This work begins with the purpose to understand how dynamics of the organization of a school have an influence in the process of introduction and use of ICT, especially the importance of the role of the headship team and its leadership in the development of this process. To accomplish that, it has been used a research design based on the analysis of a multiple Case Study at three different moments, from a Grounded Theory approach. A type of headship team "e-competent ' has been identified, which is mainly characterized by its strong educational, transformational and distributed leadership and motivation to develop measures and strategies to promote the integration of ICT. As a result, it was found that the management leadership is a key factor in promoting educational innovation, especially in the integration of ICT in schools, as it will greatly affect the organization and decision-making, acting as a catalyst and facilitator of this process. Key words: Integration of ICT, School organization, Headship team, Educational leadership, Transformational leadership, Distributed leadership, Digital competence.
Relationships of a Circular Singer Arm Gesture to Acoustical and Perceptual Measures of Singing

The purpose of this study was to validate previous research that suggests using movement in conjunction with singing tasks can affect intonation and perception of the task. Singers (N = 49) were video and audio recorded, using a motion capture system, while singing a phrase from a familiar song, first with no motion, and then while doing a low, circular arm gesture. Analysis of relationships between a circular singer arm gesture and changes in intonation indicated most singers (67.3%, n = 33) were closer to the target pitch when doing the low, circular gesture. Additionally, significant correlations were found between motion of the hand and face. Participant perceptions of singing with motion included “fuller tone” and “more breath” with the lower motion and singing without motion viewed as “easy” and “comfortable. ” Results of this study suggest that singing with motion can affect intonation, other bodily movements, and perception of singing.
Is universal prevention against youths’ substance misuse really universal? Gender-specific effects in the EU-Dap school-based prevention trial

Background: Studies of effectiveness of school-based prevention of substance misuse have generally overlooked gender differences. The purpose of this work was to analyse gender differences in the effectiveness of a new European school-based curriculum for prevention of substance misuse among adolescents. Methods: The European Drug Abuse Prevention (EU-Dap) trial took place in seven European countries during the school year 2004–05. Schools were randomly assigned to either a control group or a 12-session standardised curriculum (“Unplugged”) based on a comprehensive social influence model. The analytical sample consisted of 6359 students (3324 boys and 3035 girls). The use of cigarettes, alcohol and illicit drugs, adolescents’ knowledge and opinions about substances, as well as social and personal skills were investigated through a self-completed anonymous questionnaire administered at enrolment and 3 months after the end of the programme. Adjusted Prevalence Odds Ratios were calculated as the measure of association between the intervention and behavioural outcomes using multilevel regression modelling. Results: At enrolment, boys were more likely than girls to have used cannabis and illicit drugs, whereas girls had a higher prevalence of cigarette smoking. At the follow-up survey, a significant association between the programme and a lower prevalence of all behavioural outcomes was found among boys, but not among girls. Age and self-esteem emerged as possible modifiers of these gender differences, but effects were not statistically significant. Conclusions: Comprehensive social influence school curricula against substance misuse in adolescence may perform differently among girls and boys, owing to developmental and personality factors.
Surgical outcome of inflammatory pseudotumor in the lung.

BACKGROUND Pulmonary inflammatory pseudotumors are rare, and little is known about their clinical behavior and surgical outcome. MATERIALS AND METHODS Between 1993 and 2003, 19 patients with inflammatory pseudotumor were managed in our hospital. We retrospectively reviewed the clinical and radiographic features, as well as the surgical outcomes. RESULTS Of the 19 patients (15 men, 4 women; mean age 53.9 years), 6 underwent lobectomy, 11 had wedge resections, and 2 had biopsy alone. There was no recurrence of the lesion in the 17 patients who underwent resection or lobectomy of the pseudotumor. There was no disease progression in the 2 patients who had only had a biopsy. CONCLUSION Inflammatory pseudotumor of the lung is relatively benign. Complete resection leads to an excellent outcome.
Investigation of 4q‐deletion in two unrelated patients using array CGH

S.S. Kaalund, R.S. Møller, A. Tészás, M. Miranda, G. Kosztolanyi, R. Ullmann, N. Tommerup, and Z. Tümer* Department of Cellular and Molecular Medicine, Wilhelm Johannsen Centre for Functional Genome Research, University of Copenhagen, Copenhagen, Denmark Danish Epilepsy Centre, Dianalund, Dianalund, Denmark Department of Medical Genetics and Child Development, University of Pécs, Pécs, Hungary Max-Planck Institute for Molecular Genetics, Berlin, Germany
Prospective observational study of carbon‐ion radiotherapy for non‐squamous cell carcinoma of the head and neck

To evaluate the efficacy and safety of carbon‐ion radiotherapy for non‐squamous cell carcinoma of the head and neck, 35 patients were enrolled in this prospective study. The primary end‐point was the 3‐year local control rate, and the secondary end‐points included the 3‐year overall survival rate and adverse events. Acute and late adverse events were evaluated according to the Common Terminology Criteria for Adverse Events, version 4.0. The median follow‐up time for all patients was 39 months. Thirty‐two and three patients received 64.0 Gy (relative biological effectiveness) and 57.6 Gy (relative biological effectiveness) in 16 fractions, respectively. Adenoid cystic carcinoma was dominant (60%). Four patients had local recurrence and five patients died. The 3‐year local control and overall survival rates were 93% and 88%, respectively. Acute grade 2–3 radiation mucositis (65%) and dermatitis (31%) was common, which improved immediately with conservative therapy. Late mucositis of grade 2, grade 3, and grade 4 were observed in 11, one, and no patients, respectively. There were no adverse events of grade 5. Carbon‐ion radiotherapy achieved excellent local control and overall survival rates for non‐squamous cell carcinoma. However, the late mucosal adverse events were not rare, and meticulous treatment planning is required. Trial registration no. UMIN000007886.
Autonomic alterations and cardiac changes in epilepsy

Studies with heart rate variability have revealed interictal autonomic alterations in patients with epilepsy. In addition, epilepsy is frequently associated with ictal tachycardia or bradycardia, which sometimes precedes the onset of seizures. Ictal tachycardia is sometimes associated with electrocardiography (ECG) morphologic changes and ictal bradycardia often progresses to asystole. Such cardiac manifestations of seizures have been hypothesized as possible causes for sudden unexplained death in epilepsy (SUPEP). The present review relates to interictal and ictal cardiac manifestations of epilepsy with focus on heart rate, heart rate variability, and ECG changes. Aspects of the supporting mechanisms are discussed and attention is drawn to the interaction between central and peripheral effects, interictal autonomic conditions, ictal autonomic discharges, and administration of antiepileptic drugs in shaping the ictal cardiac changes. Because these interactions are complex and not totally understood, closer surveillance of patients and more experimental work is necessary to elucidate the mechanistic support of autonomic and cardiac changes in epilepsy, and to design better strategies to avoid their undesirable effects. It is also suggested that some of these changes could be used as predictors or markers for the onset of seizures.
A potential framework for the debate on general cognitive ability and testing

symbolic reasoning in an Air Force intelligence career field. Educational and Psychological Measurement, 53(4), 993-997. Besetsny, L. K. , Ree, M. J., & Earles, J. A. (1993). Special test for computer programmers? Not needed: The predictive efficiency of the Electronic Data Processing Test for a sample of Air Force recruits. Educational and Psychological Measurement, 53(2), 507-511. Berry, J.W. (1986). A cross-cultural view of intelligence. In R. Sternberg and D. K. Detterman (Eds). What is intelligence? : Contemporary viewpoints on its nature and definition, (pp. 35-38). Norwood, NJ: Ablex. Bingham, W. V. (1937). Aptitudes and aptitude testing. New York: Harper & Brothers. Bishop, J. H. (1988). Employment testing and incentives to learn. Journal of Vocational Behavior, 33(3), 404-423. Bobko, P., Roth, P. L. , & Potosky, D. (1999). Derivation and implications of a meta-analytic matrix incorporating cognitive ability, alternative predictors, and job performance. Personnel Psychology, 52(3), 561-589. Boring, E. G. (1923). Intelligence as the Tests Test It. New Republic, 36. 35-37. Borman, W. C. , Hanson, M. A. , & Hedge, J. W. (1997). Personnel selection. Chapter in J. T. Spence (Ed.). Annual Review of Psychology (pp. 299-337). Palo Alto, CA: Annual Reviews, Inc. Borman, W. C. , & Motowidlo, S. J. (1993b). Expanding the criterion domain to include elements of contexual performance. In W. C. Borman (Ed.), Personnel Selection in Organizations (pp. 71-98). New York, NY: Jossey-Bass.
A teacher's perspective on autonomy and self-access: from theory to perception to practice

ABSTRACT Considerable resources are expended on the development of learner autonomy (LA), and in particular on the provision of self-access facilities as one of the most common ways in which institutions have tried to foster autonomy. Whether the intended outcomes are achieved depends in large part on teachers’ agreement with and understanding of the rationale behind these efforts. A mismatch between an institutional objective and a classroom implementation may, for example, negatively impact the student experience. This project looks at teachers’ perspectives on LA and self-access language learning in a university setting where a self-access component was introduced as a compulsory element of students’ first-year courses. How do teachers conceptualise autonomous learning, what importance do they assign to it, and how do they attempt to foster autonomy in practice? What role do they see for self-access learning in this? In this project, we used a mixed-methods approach and obtained questionnaire data from 47 teachers on an English as a Foreign Language programme at a university in Thailand, as well as qualitative data from in-depth interviews with 5 teachers, on their beliefs about autonomy and self-access. The results show a complex interplay between teachers’ beliefs, institutional constraints, and classroom implementation.
Management outcomes of abruptio placentae at Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria.

BACKGROUND The objective of this study is to determine incidence, risk factors and management outcomes of abruptio placentae (AP) and comparing them with cases without AP who delivered within the same period. METHODS A 10 year retrospective study of AP managed at Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria, between January 2001 and December 2010 was undertaken. Proforma was initially used for data collection before transfer to Epi-info 2008 software. Test of associations were evaluated and P < 0.05 was considered significant. RESULTS Sixty nine cases out of a total delivery of 8,811 were seen, giving an incidence of 0.8%. The mean age and parity of women with AP were 30.8 +/- 0.9 years and 4.1 +/- 0.6 respectively and majority (78.3%) of cases were unbooked (p = 0.0019). Grand multiparity and age = 35 years were significant risk factors ( p < 0.05). Fifty two (75.4%) cases were delivered by caesarean section (c/s) ( P = 0.0000). The sex ratio was 160 ( p = 0.0134). The overall maternal mortality ratio during the study period was 987 per 100,000 live births with AP contributing 3.8% of the maternal deaths while perinatal mortality rate was 52.2%. CONCLUSION A significant number of cases have high perinatal mortality. Unbooked, high parity, advanced maternal age and previous c/s scar were significant aetiological risk factors.
Philosophical Anthropology

The concept of philosophical anthropology is polysemous. These words carry the most diverse and sometimes mutually incompatible nuances of metaphysical thought. It is difficult to judge what criterion would enable us to draw the necessary demarcations. For example, the early writings of the French moralists, in which they discussed human nature, are considered to belong to philosophical anthropology. However, few would classify Arthur Schopenhauer's Aphorisms of Everyday Wisdom [Aphorismen zur Lebensweisheit] as metaphysical literature, although they contain a typology of human needs.1
Cerebral Hemodynamics During Spinal Cord Stimulation

An increase of cerebral blood flow (CBF) during spinal cord stimulation (SCS) has been shown in man using the 133Xenon inhalation technique. We report the effects of SCS on cerebral hemodynamics studied with transcranial Doppler sonography (TCD). Twenty‐six patients with epidural electrodes implanted at the cervical level (11 patients) and at the thoracic level (15 patients) were investigated with recordings of CBF velocity in the middle cerebral arteries before and during SCS, Sixty‐three and two‐thirds percent of patients with cervical stimulation and 29.4% of patients with thoracic stimulation showed a decrease afcerebral vas‐cularresistance simultaneously with an increase of the velocity of CBF.
TREATMENT OF DEPRESSION IN CARDIOVASCULAR DISEASE

Depression in patients with Cardiovascular Disease (CVD) is extremely common, with a prevalence of 17–47%, and is associated with increased risk of morbidity and mortality. Treatment of depression has been hypothesized to reduce cardiac mortality. Pharmacologic and psychotherapeutic interventions have been studied and appear to be safe and in some studies effective in reducing depressive symptoms in patients with cardiac disease. The impact on cardiac outcomes remains unclear. This review briefly focuses on the prevalence of depression in patients with CVD, the physiological links between depression and CVD, and largely is concerned with the clinical trials that seek to demonstrate efficacy and safety of antidepressant medications and psychotherapy in this patient population.
A metabolic syndrome in diffuse idiopathic skeletal hyperostosis. A controlled study.

OBJECTIVE I addition to diabetes mellitus (DM), high incidence of common metabolic conditions such as dyslipidemia (DL) and hyperuricemia (HU) has been found in patients with diffuse idiopathic skeletal hyperostosis (DISH). Our objective was to confirm such observations comparing data from patients with DISH and appropriate controls. METHODS One hundred randomly identified inpatients with DISH were compared with 100 DISH-free inpatients with various rheumatic disorders matched for age, sex, body mass index, and excess body weight. The prevalence of metabolic disturbances was compared in the 2 groups. Data was analyzed statistically by chi-squared test and 4-fold table analysis. RESULTS In our DISH population, metabolic abnormalities were found in 70%, versus 45% in the control population (p < 0.0001). High prevalence of DL and/or HU associated with DM was observed among patients with DISH (p < 0.0001). Patients with uncomplicated diabetes (or DL or HU) were almost equally distributed between the 2 groups, with no significant differences (p > 0.1). Combined metabolic features of DM+DL, DM+HU, or DM+DL+HU were shown to be the main risk factor for DISH (K = 14). They may constitute a metabolic syndrome with high diagnostic specificity (u = 1.0) and nosologic sensitivity (g = 1.0), despite their lowest prevalence (0.07). Dyslipidemia occurred with the highest prevalence (p = 0.36), the highest positive predictive value (v = 0.44) and, together with HU and diabetes, the highest nosologic specificity (f = 0.55 in both cases). CONCLUSION We found metabolic disturbances confined to the group with DISH. Followup studies of the number of bridging ossifications in identically aged patients or bridging ossifications/year/patient could be a useful tool to determine their effect on the extent and progression rates of DISH.
Functional characterization of the ABF gene family in upland cotton (Gossypium hirsutum L.)

The AREB/ABF bZIP transcription factors play a pivotal role in abscisic acid-dependent abiotic stress-responsive gene expression. Despite the perennial damage and reduced productivity that result from water-deficit and unpredictable early season temperature fluctuations, these critical genes have not been previously examined in upland cotton (Gossypium hirsutum). Here, we report the isolation of the G. hirsutum ABF homologs, characterization of their expression patterns in response to abiotic stress treatments, and examination of their functions through heterologous ectopic expression in Arabidopsis. As expected for an allotetraploid, G. hirsutum ABF homologs are present in the genome as homeologous pairs. These genes are differentially expressed, both among the homologs and within the homeologous pairs, in response to exogenous abscisic acid (ABA) application, dehydration, and chilling temperatures. Furthermore, heterologous ectopic expression of many of the G. hirsutum ABF genes in Arabidopsis conferred increased tolerance to water deficit and osmotic stress, as well as cold tolerance, in a gene specific manner. These results indicate the G. hirsutum ABF homologs are functional in Arabidopsis and, as in other species, are likely to play an essential role in the abiotic stress response. Highlight The Gossypium hirsutum ABF homeologs are differentially expressed in response to abiotic stress, and their ectopic expression in Arabidopsis can confer increased water deficit tolerance.
CHOP followed by involved field radiotherapy for localized primary gastric diffuse large B-cell lymphoma: Results of a multi center phase II study and quality of life evaluation

We aimed to define the role of cyclophosphamide, vincristine, doxorubicin, prednisone (CHOP) followed by involved field radiotherapy (IFRT) for treating localized primary gastric diffuse large B-cell lymphoma (DLBCL). Newly diagnosed patients with localized primary gastric DLBCL were to receive four cycles of CHOP followed by IFRT of 40.0 Gy. At 1 year after the completion of treatment, patients filled out the EORTC Quality of Life Questionnaire specified for stomach cancer (QLQ-C30-STO22). Fifty evaluable patients (25 men, 25 women) were included. The median age was 54.5 years (range, 21 – 73 years. The overall response rate to the CHOP was 94% (95% confidence interval [CI], 87 – 100) in the intent-to-treat population. Forty-one of the 50 patients (82%; 95% CI, 71 – 93) achieved complete remission (CR). After the completion of radiotherapy, five patients who were in PR following chemotherapy eventually attained CR. The overall complete response rate was thus 92% (95% confidence interval, 84 – 99). With a median follow-up period of 30 months, the 2-year progression-free and overall survival rate was 92% and 92%, respectively. The gastric function was well preserved with negligible stomach-related symptoms at 1 year after the completion of treatment. This organ-preserving combined treatment is highly effective and well tolerated for the patients with localized gastric DLBCL.