Miracle-dz/UniFAR-FTUs huggingface dataset:
Inflammatory potential in relation to the microbial content of settled dust samples collected from moisture-damaged and reference schools: results of HITEA study.

Aiming to identify factors causing the adverse health effects associated with moisture-damaged indoor environments, we analyzed immunotoxicological potential of settled dust from moisture-damaged and reference schools in relation to their microbiological composition. Mouse RAW264.7 macrophages were exposed to settled dust samples (n = 25) collected from moisture-damaged and reference schools in Spain, the Netherlands, and Finland. After exposure, we analyzed production of inflammatory markers [nitric oxide (NO), tumor necrosis factor-α (TNF-)α, interleukin (IL)-6, and macrophage inflammatory protein (MIP)2] as well as mitochondrial activity, viability, apoptosis, and cell cycle arrest. Furthermore, particle counts, concentration of selected microbial groups as well as chemical markers such as ergosterol, 3-hydroxy fatty acids, muramic acid, endotoxins, and glucans were measured as markers of exposure. Dust from moisture-damaged schools in Spain and the Netherlands induced stronger immunotoxicological responses compared to samples from reference schools; the responses to Finnish samples were generally lower with no difference between the schools. In multivariate analysis, IL-6 and apoptosis responses were most strongly associated with moisture status of the school. The measured responses correlated with several microbial markers and numbers of particles, but the most important predictor of the immunotoxicological potential of settled dust was muramic acid concentration, a marker of Gram-positive bacteria.
Facility design consequences of different employees’ quality perceptions

An important challenge for facility management is to integrate the complex and comprehensive construct of different service processes and physical elements of the service facility into a meaningful and functional facility design. The difficulty of this task is clearly indicated by the present study that shows that different employee categories for interpersonal services have quite different perceptions of the facility design that stem from different but coherent needs and interests. Employees with management perspectives (i.e. top managers and facility managers) were significantly more positive about the facility design than frontline employees and their supervisors with providers’ perspectives. Also, providers attributed a more important role to facility design with respect to delivering interpersonal services than management did. We found strong indications for the need for cross-functional cooperation in decision making about the facility design, creating a more balanced setting and possibly empowering providers for the service encounter.
Exchange-Rate Pass-Through in the G-7 Countries

This paper examines the current thinking on exchange-rate pass-through to both import prices and consumer prices and estimates the extent to which they have fallen in the G-7 countries since the late 1970s and 1980s. For import-price pass-through we find that all countries experience a numerical decline in the responsiveness of import prices to exchange-rate movements; for nearly half of these countries the decline between 1975-1989 and 1990-2004 is statistically significant. We estimate that while a 10 percent depreciation in the local currency would have increased import prices by nearly 7 percent on average across these countries in the late 1970s and 1980s, it would have only increased import prices by 4 percent in the last 15 years. The responsiveness of consumer prices to exchange-rate movements declines for nearly every country, with the decline being statistically significant for two countries. Specifically, while a 10 percent depreciation in the local currency would have increased consumer prices by almost 2 percent on average in the late 1970s and 1980s, it would have had a neutral effect on consumer prices in the last 15 years.
Inflation, Taxation and the Valuation of Shares

Abstract A share valuation model is developed that takes account of the possibility of shareholding periods extending beyond one year, income taxes, capital gains taxes paid on realised gains and indexation for inflation. For an infinite dividend series, an optimal shareholding period is derived, which is shown to be related to the level of the after-tax risky rate, discounted at the growth rate, vis-a-vis the after-tax riskless rate, deflated for the general rate of inflation. In turn, this determines whether or not the value of the share is indifferent to the capital gains tax rate and the rate of inflation.
Productivity and resistance to weed invasion in four prairie biomass feedstocks with different diversity

High‐diversity mixtures of native tallgrass prairie vegetation should be effective biomass feedstocks because of their high productivity and low input requirements. These diverse mixtures should also enhance several of the ecosystem services provided by the traditional monoculture feedstocks used for bioenergy. In this study, we compared biomass production, year‐to‐year variation in biomass production, and resistance to weed invasion in four prairie biomass feedstocks with different diversity: one species – a switchgrass monoculture; five species – a mix of C4 grasses; 16 species – a mix of grasses, forbs, and legumes; and 32 species – a mix of grasses, forbs, legumes, and sedges. Each diversity treatment was replicated four times on three soil types for a total of 48 research plots (0.33–0.56 ha each). We measured biomass production by harvesting all plant material to ground level in ten randomly selected quadrats per plot. Weed biomass was measured as a subset of total biomass. We replicated this design over a five‐year period (2010–2014). Across soil types, the one‐, 16‐, and 32‐species treatments produced the same amount of biomass, but the one‐species treatment produced significantly more biomass than the five‐species treatment. The rank order of our four diversity treatments differed between soil types suggesting that soil type influences treatment productivity. Year‐to‐year variation in biomass production did not differ between diversity treatments. Weed biomass was higher in the one‐species treatment than the five‐, 16‐, and 32‐species treatments. The high productivity and low susceptibility to weed invasion of our 16‐ and 32‐species treatments supports the hypothesis that high‐diversity prairie mixtures would be effective biomass feedstocks in the Midwestern United States. The influence of soil type on relative feedstock performance suggests that seed mixes used for biomass should be specifically tailored to site characteristics for maximum productivity and stand success.
The role of tolloid/mini fin in dorsoventral pattern formation of the zebrafish embryo.

A highly conserved TGF-&bgr; signaling pathway is involved in the establishment of the dorsoventral axis of the vertebrate embryo. Specifically, Bone Morphogenetic Proteins (Bmps) pattern ventral tissues of the embryo while inhibitors of Bmps, such as Chordin, Noggin and Follistatin, are implicated in dorsal mesodermal and neural development. We investigated the role of Tolloid, a metalloprotease that can cleave Chordin and increase Bmp activity, in patterning the dorsoventral axis of the zebrafish embryo. Injection of tolloid mRNA into six dorsalized mutants rescued only one of these mutants, mini fin. Through chromosomal mapping, linkage and cDNA sequence analysis of several mini fin alleles, we demonstrate that mini fin encodes the tolloid gene. Characterization of the mini fin mutant phenotype reveals that Mini fin/Tolloid activity is required for patterning ventral tissues of the tail: the ventral fin, and the ventroposterior somites and vasculature. Gene expression studies show that mfn mutants exhibit reduced expression of ventrally restricted markers at the end of gastrulation, suggesting that the loss of ventral tail tissues is caused by a dorsalization occurring at the end of gastrulation. Based on the mini fin mutant phenotype and the expression of tolloid, we propose that Mini fin/Tolloid modifes the Bmp activity gradient at the end of gastrulation, when the ventralmost marginal cells of the embryo are in close proximity to the dorsal Chordin-expressing cells. At this time, unimpeded Chordin may diffuse to the most ventral marginal regions and inhibit high Bmp activity levels. In the presence of Mini fin/Tolloid, however, Chordin activity would be negatively modulated through proteolytic cleavage, thereby increasing Bmp signaling activity. This extracellular mechanism is amplified by an autoregulatory loop for bmp gene expression.
Mast cell ultrastructure in the inferior turbinate and stroma of nasal polyps

Abstract Fourteen unselected adult patients with nasal polyps had ultrastructural examination of mast cells from matching biopsies of the polyp and inferior turbinate. Between three and 10 blocks were examined for each patient in both tissues and every mast cell that had a nucleus was photographed for study. Fifty-three mast cells were found within the stroma of nasal polyps and 54 in the submucosa of the inferior turbinate biopsies. The number of granules ranged between 13 and 167 (mean 60) for polyps and 18 and 148 (mean 61) in the inferior turbinate. The mast cells appeared essentially normal in the inferior turbinate of four patients. The degree of degranulation of the mast cells was calculated as in previous studies and then averaged for both the polyp and the inferior turbinate of each patient. There was greater degranulation in the nasal polyp compared to inferior turbinate (p= 0.03). These results were compared with mast cell degranulation found in the normal nose and in the inferior turbinate of patients with perennial allergic rhinitis which we previously published. The inferior turbinates in these patients were more degranulated than the normal nose (p= 0.0001) but were similar to that found in patients with perennial allergic rhinitis. This suggested that some degree of degranulation may occur throughout the nose in two thirds of the patients with nasal polyps which supports the theory that mast cell reactions are not limited to the polyps in a proportion of patients.
The Relationship Between Line Manager Behavior, Perceived HRM Practices, and Individual Performance: Examining the Mediating Role of Engagement

This article examines the role played by line managers in the link between HRM practices and individual performance outcomes. Drawing on social exchange theory, the authors test a mediated model linking perceived line manager behavior and perceived human resource management practices with employee engagement and individual performance. The study focuses on two self-report measures of individual performance; task performance and innovative work behavior. Two studies with a total of 1,796 participants were conducted in service-sector organizations in the United Kingdom and analyzed using structural equation modeling. The data reveal that perceived line manager behavior and perceived HRM practices are linked with employee engagement. In turn, employee engagement is strongly linked to individual performance and fully mediates the link between both perceived HRM practices and perceived line manager behavior and self-report task performance (study 1), as well as self-report innovative work behavior (study 2). The findings show the significance of the line manager in the HRM-performance link, and the mediating role played by employee engagement. © 2013 Wiley Periodicals, Inc.
Involvement of Connective Tissue Growth Factor in Human and Experimental Hypertensive Nephrosclerosis

Background/Aims: Connective tissue growth factor (CTGF; CCN2) has been implicated as a marker and mediator of fibrosis in human and experimental renal disease. Methods: We performed a comparative analysis of CTGF expression in hypertensive patients with and without nephrosclerosis, and in uninephrectomized and sham-operated spontaneously hypertensive rats (UNX-SHR and 2K-SHR). Results: Urinary and plasma CTGF were elevated in patients with hypertensive nephrosclerosis, and increased renal CTGF expression was mainly localized in podocytes. Accordingly, elevation of urinary, plasma, and tissue CTGF in UNX-SHR coincided and correlated with proteinuria, glomerulosclerosis, and tubulointerstitial fibrosis. Thirty-two weeks after uninephrectomy, mean glomerular CTGF mRNA expression was increased 1.3-fold over baseline, mainly due to 1.7-fold higher expression in glomeruli undergoing sclerosis. In parallel, tubulointerstitial CTGF and α-smooth muscle actin were upregulated in UNX-SHR. CTGF was increased in the media of arcuate and interlobar arteries, while arterioles remained negative. Conclusions: Glomerulosclerosis, tubulointerstitial fibrosis, and arterial media hypertrophy lesions of hypertensive nephrosclerosis are all characterized by increased CTGF tissue expression, which is associated with a concomitant increase in CTGF in blood and urine. These findings identify CTGF as a promising biomarker for progression of hypertensive nephrosclerosis, and as a likely key factor in the pathogenesis of this disease.
Mulberry (桑葚子 Sang Shèn Zǐ) and its Bioactive Compounds, the Chemoprevention Effects and Molecular Mechanisms In Vitro and In Vivo

Mulberry (桑葚子 sāng shèn zǐ), a traditional Chinese medicine (TCM) in Taiwan, has many bioactive substances, including polyphenol and anthocyanins compounds. Over the past decade, many scientific and medical studies have examined mulberry fruit for its antioxidation and antiinflammation effects both in vitro and in vivo. This review thus focuses on the recent advances of mulberry extracts (MEs) and their applications in the prevention and treatment of human cancer, liver disease, obesity, diabetes, and cardiovascular disease. The ME modulates several apoptotic pathways and matrix metalloproteinases (MMPs) to block cancer progression. Mulberry can increase detoxicated and antioxidant enzyme activities and regulate the lipid metabolism to treat hepatic disease resulting from alcohol consumption, high fat diet, lipopolysaccharides (LPS) and CCl 4 exposure. Of the various compounds in ME, cyanidin 3-glucoside (C3G) is the most abundant, and the active compound studied in mulberry research. Herein, the antioxidant and antiinflammatory actions of C3G to improve diabetes and cardiovascular disease are also discussed. These studies provide strong evidence ME may possess the bioactivity to affect the pathogenesis of several chronic diseases.
Multimodal Learning and Reasoning for Visual Question Answering

Reasoning about entities and their relationships from multimodal data is a key goal of Artificial General Intelligence. The visual question answering (VQA) problem is an excellent way to test such reasoning capabilities of an AI model and its multimodal representation learning. However, the current VQA models are over-simplified deep neural networks, comprised of a long short-term memory (LSTM) unit for question comprehension and a convolutional neural network (CNN) for learning single image representation. We argue that the single visual representation contains a limited and general information about the image contents and thus limits the model reasoning capabilities. In this work we introduce a modular neural network model that learns a multimodal and multifaceted representation of the image and the question. The proposed model learns to use the multimodal representation to reason about the image entities and achieves a new state-of-the-art performance on both VQA benchmark datasets, VQA v1.0 and v2.0, by a wide margin.
The effect of electronic dental anesthesia on behavior during local anesthetic injection in the young, sedated dental patient.

PURPOSE The purpose of this study was to evaluate the effectiveness of the 3M Electronic Dental Anesthesia (EDA) finger electrode on reducing sedated patient responsiveness during local anesthesia administration. METHODS Thirty patients between the ages of 24 to 48 months, ASA I, and in need of treatment of maxillary anterior teeth using local anesthesia were used in this study. Each of the patients received chloral hydrate (CH) and hydroxyzine (50 mg/kg and 2 mg/kg, respectively). The patients were divided randomly in two groups. The experimental group received activated electronic dental anesthesia (AEDA) while the control group had a nonactive EDA (NAEDA). Physiological parameters were recorded and behavior was videotaped and rated using the Ohio State University Behavior Rating Scale. A repeated-measures ANOVA, Student's tests, and descriptive statistics were used. RESULTS The results indicated that the heart rate and diastolic blood pressure of both groups were significantly affected as a function of time and dental procedures. A significant effect in the percent change of heart rate between groups was noted during local anesthetic injection with the NAEDA group having an increased heart rate. There was a higher occurrence of movement in the NAEDA compared to the AEDA. CONCLUSION The EDA appears to be beneficial in reducing the discomfort, as judged by behavioral and physiologic observations, associated with local anesthetic administration in young sedated dental patients.
Quality of Working Life and Productivity: An Overview of the Conceptual Framework

This study aimed to discuss some relationships regarding the Quality of Working Life (QWL) and human productivity performance. For this, a bibliographical review was raised achieving the theoretical foundation to support this discussion, the research question was: in nowadays is already possible to think in an effective quality of working live dissociated from productivity? From results, we evidenced that substantial loss of productivity was related with absenteeism presenteeism and several workdiseases, consequently decreasing the health and welfare of employee’s. Moreover, the management of quality must influence the decisions of employee’s, thus enhancing their commitment and insuring selfwellness, ergo increasing their productivity. Concluding, the harms which afflict humans are the result between the combinations of their work development with their lifestyle outside of work.
Unraveling the Role of Mitochondria During Oxidative Stress in Plants

The sedentary habit of plants means that they must stand and fight environmental stresses that their mobile animal cousins can avoid. A range of these abiotic stresses initiate the production in plant cells of reactive oxygen and nitrogen species that ultimately lead to oxidative damage affecting the yield and quality of plant products. A complex network of enzyme systems, producing and quenching these reactive species operate in different organelles. It is the integration of these compartmented defense systems that coordinates an effective response to the various stresses. Future attempts to improve plant growth or yield must consider the complexity of inter‐organelle signaling and protein targeting if they are to be successful in producing plants with resistance to a broad range of stresses. Here we highlight the role of pre‐oxidant, anti‐oxidant, and post‐oxidant defense systems in plant mitochondria and the potential role of proteins targeted to both mitochondria and chloroplasts, in an integrated defense against oxidative damage in plants.
The Moderating Effect of Cognitive Capability on Task Conflict: A Longitudinal Study of Task Conflict and Team Performance in Student Software Development Teams

For software development teams to achieve development success, task conflict needs to be managed skillfully to counteract its undesirable consequences to team performance. Conflict is dynamic in nature, and its effect on team performance varies during software development lifecycle. Based on information processing theory and team cognition theory, this study proposes cognitive capability as an important moderator on the task conflict – team performance relationship. A longitudinal study was conducted in 70 student software development teams and multi-level model of change was applied to analyze the data collected at different time points. Results supported the proposition that while task conflict interferes with team performance, its detrimental effects get more sever over time; and cognitive capability, which develops along with the maturing of team cognition as team members work together on the focal project, helps restrain and convert the undesirable effect of task conflict on team performance toward beneficial and constructive. Keyword: task conflict, software development teams, cognitive capability, longitudinal study He, Moderating Effect of Cognitive Capability on Task Conflict 2 The Moderating Effect of Cognitive Capability on Conflict: A Longitudinal Study of Conflict and Team Performance in Student Software Development Teams
A Non-Linear Tourism Demand Forecast Combination Model

It has been demonstrated in the tourism literature that a combination of individual tourism forecasting models can provide better performance than individual forecasting models. However, the linear combination uses only inputs that have a linear correlation to the actual outputs. This paper proposes a non-linear combination method using multilayer perceptron neural networks (MLPNN), which can map the non-linear relationship between inputs and outputs. UK inbound tourism quarterly arrivals data by purpose of visit are used for this case study. The empirical results show that the proposed non-linear MLPNN combination model is robust, powerful and can provide better performance at predicting arrivals than linear combination models.
Waxing or waning? The changing patterns of environmental activism

Is environmental action waxing or waning? Using the environmental modules of the International Social Survey Program from 1993, 2000, and 2010, two dimensions of environmental activism are described: environmental political activity and conservation behavior. Political activity has generally decreased, but in contrast, conservation behavior has become more common over the same time span. The correlates of these changes suggest that broad societal forces produced these trends, since most social groups follow these same trends, although some evidence was found of increased partisan polarization in Green activism.
Toward a multi‐dimensional measure of individual innovative behavior

Individual level innovation studies often assess only one dimension of innovative behavior. As such, they do not sufficiently capture the richness of the construct of individual innovation. Develops and tests a multi‐dimensional measure of individual innovative behavior. Identifies descriptions of 289 innovation related behaviors and codes these into a hypothesized factor structure consisting of the following five dimensions: opportunity exploration, generativity, formative investigation, championing, and application. Structural equation modeling used on a sample of 225 employees from nine different organizations delivered a relatively poor fit between the hypothesized factor structure and respondents’ job behaviors. However, a single factor measure based on items representing all five factors resulted in an alpha reliability of 0.95 thus supporting a multi‐dimensional conceptualization of innovative behavior in general. Discusses implications for future research.