Miracle-dz/UniFAR-FTUs huggingface dataset:
CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells

Regulatory T (T reg) cells are critical regulators of immune tolerance. Most T reg cells are defined based on expression of CD4, CD25, and the transcription factor, FoxP3. However, these markers have proven problematic for uniquely defining this specialized T cell subset in humans. We found that the IL-7 receptor (CD127) is down-regulated on a subset of CD4+ T cells in peripheral blood. We demonstrate that the majority of these cells are FoxP3+, including those that express low levels or no CD25. A combination of CD4, CD25, and CD127 resulted in a highly purified population of T reg cells accounting for significantly more cells that previously identified based on other cell surface markers. These cells were highly suppressive in functional suppressor assays. In fact, cells separated based solely on CD4 and CD127 expression were anergic and, although representing at least three times the number of cells (including both CD25+CD4+ and CD25−CD4+ T cell subsets), were as suppressive as the “classic” CD4+CD25hi T reg cell subset. Finally, we show that CD127 can be used to quantitate T reg cell subsets in individuals with type 1 diabetes supporting the use of CD127 as a biomarker for human T reg cells.
The SNP rs931794 in 15q25.1 Is Associated with Lung Cancer Risk: A Hospital-Based Case-Control Study and Meta-Analysis

Background Lung cancer is one of the most common human malignant diseases and the leading cause of cancer death worldwide. The rs931794, a SNP located in 15q25.1, has been suggested to be associated with lung cancer risk. Nevertheless, several genetic association studies yielded controversial results. Methods and Findings A hospital-based case-control study involving 611 cases and 1062 controls revealed the variant of rs931794 was related to increased lung cancer risk. Stratified analyses revealed the G allele was significantly associated with lung cancer risk among smokers. Following meta-analysis including 6616 cases and 7697 controls confirmed the relevance of rs931794 variant with increased lung cancer risk once again. Heterogeneity should be taken into account when interpreting the consequences. Stratified analysis found ethnicity, histological type and genotyping method were not the sources of between-study heterogeneity. Further sensitivity analysis revealed that the study “Hsiung et al (2010)” might be the major contributor to heterogeneity. Cumulative meta-analysis showed the trend was increasingly obvious with adding studies, confirming the significant association. Conclusions Results from our current case-control study and meta-analysis offered insight of association between rs931794 and lung cancer risk, suggesting the variant of rs931794 might be related with increased lung cancer risk.
Evaluation of Non-Intrusive Approaches for Wiener-Askey Generalized Polynomial Chaos.

Polynomial chaos expansions (PCE) are an attractive technique for uncertainty quantification (UQ) due to their strong mathematical basis and ability to produce functional representations of stochastic variability. When tailoring the orthogonal polynomial bases to match the forms of the input uncertainties in a Wiener-Askey scheme, excellent convergence properties can be achieved for general probabilistic analysis problems. Non-intrusive PCE methods allow the use of simulations as black boxes within UQ studies, and involve the calculation of chaos expansion coefficients based on a set of response function evaluations. These methods may be characterized as being either Galerkin projection methods, using sampling or numerical integration, or regression approaches (also known as point collocation or stochastic response surfaces), using linear least squares. Numerical integration methods may be further categorized as either tensor product quadrature or sparse grid Smolyak cubature and as either isotropic or anisotropic. Experience with these approaches is presented for algebraic and PDE-based benchmark test problems, demonstrating the need for accurate, efficient coefficient estimation approaches that sca le for problems with significant numbers of random variables.
The Natural History of Gambling and Drinking Problems Among Casino Employees

Abstract From an eligible population of 9,943 casino employees, 6,067 volunteered to participate in this study. Of this sample, 1,176 provided data at 3 observation points approximately 12 months apart. Using the South Oaks Gambling Screen (SOGS; H. R. Lesieur & S. B. Blume, 1987) and the CAGE (J. A. Ewing, 1984) questionnaire, the authors prospectively examined the prevalence and patterns of alcohol and gambling problems among those employees. Among the casino employees with gambling and drinking problems, a segment displayed the capacity to diminish those problems even when the difficulties had reached disordered levels. The authors also examined the comorbidity of gambling and drinking as well as the relationships among changes in SOGS scores and CAGE scores and changes in demographic and biological variables. The women were more likely to decrease their problem-drinking scores, but not their gambling scores, when compared with the men. In addition, 2 key variables (i.e., disabling depression and dissatisfaction with one's personal life) emerged as predictors of transitions to healthier levels of disordered gambling. The authors cautiously suggest, in light of the results taken together, that more fluctuation is associated with gambling and drinking problems than previously thought and that the conventional wisdom about disordered gambling as “always progressive” needs reconsideration.
Production of Extracellular Laccase from Bacillus subtilis MTCC 2414 Using Agroresidues as a Potential Substrate

Laccases are the model enzymes for multicopper oxidases and participate in several applications such as bioremediation, biopulping, textile, and food industries. Laccase producing bacterium, Bacillus subtilis MTCC 2414, was subjected to optimization by conventional techniques and was partially purified using ammonium salt precipitation method. The agroresidue substrates used for higher yield of laccase were rice bran and wheat bran. Maximum production was achieved at temperature 30°C (270 ± 2.78 U/mL), pH 7.0 (345 ± 3.14 U/mL), and 96 h (267 ± 2.64 U/mL) of incubation. The carbon and nitrogen sources resulted in high enzyme yield at 3% sucrose (275 ± 3.11 U/mL) and 3% peptone (352.2 ± 4.32 U/mL) for rice bran and 3% sucrose (247.4 ± 3.51 U/mL) and 3% peptone (328 ± 3.33 U/mL) for wheat bran, respectively. The molecular weights of partially purified laccase were 52 kDa for rice bran and 55 kDa for wheat bran. The laccase exhibited optimal activity at 70°C (260.3 ± 6.15 U/mL), pH 9.0 (266 ± 4.02 U/mL), and metal ion CuSO4 (141.4 ± 6.64) was found to increase the production. This is the first report that delivers the higher yield of laccase produced from B. subtilis MTCC 2414 using agroresidues as a potential substrate.
Supporting Mobile Service Usage through Physical Mobile Interaction

Although mobile services can be used ubiquitously, their employment and the interaction with them are still restricted by the constraints of mobile devices. In order to facilitate and leverage mobile interaction with services, we present a generic framework that combines semantic Web service technology and physical mobile interaction. This interaction paradigm uses mobile devices to extract information from augmented physical objects and use it for a more intuitive and convenient invocation of associated services. For that purpose, the presented framework exploits Web service descriptions for the automatic and dynamic generation of customizable user interfaces that support and facilitate physical mobile interaction. This generic approach to mobile interaction with services through the interaction with physical objects promises to meet the complementary development of the Internet of things. A user study with a prototype application for mobile ticketing confirms our concept and shows its limits
The relationship of neuroticism, psychoticism and depression with visual evoked potentials

The aim of this study was to investigate the relationship between visual evoked potentials (N1, P2, N2, P3 and Sw) and levels of neuroticism, psychoticism and depression. Based on previous research, longer EP-latencies were expected in more depressed subjects, and smaller EP-amplitudes in subjects with higher levels of neuroticism and psychoticism. The sample consisted of female psychology students (N=54), age 19-23, all right-handed. After measuring Eysenck’s personality dimensions with EPQ/R, and depression with D-92, evoked potentials were measured in two trials by means of the EMG/EP device Medelec/TECA SapphireII, 4E. Significantly lower P2-amplitudes, reflecting early stimuli processing, and lower N2-amplitudes, reflecting stimuli characteristic assignment, were found in subjects with higher neuroticism. The most stable relation, determined in both trials, was the one between P2-amplitude and neuroticism. Higher amplitudes of N2 and P3, representing attention allocation and memory updating, were significantly correlated with higher psychoticism. Finally, as expected, slow wave latency was significantly prolonged in more depressed subjects. Eysencks’ personality theory and over-arousal hypothesis are used as theoretical frames for discussing the results and future research guidelines. The research findings significantly contribute to the understanding of biological determination within rarely explored personality traits, such as neuroticism, psychoticism and depression. However, since the research has some limitations, concrete guidelines for future electrophysiological studies in the field of human personality have been recommended.
Self-Selection into Credit Markets: Evidence from Agriculture in Mali

We partnered with a micro-lender in Mali to randomize credit offers at the village level. Then, in no-loan control villages, we gave cash grants to randomly selected households. These grants led to higher agricultural investments and profits, thus showing that liquidity constraints bind with respect to agricultural investment. In loan-villages, we gave grants to a random subset of farmers who (endogenously) did not borrow. These farmers have lower – in fact zero – marginal returns to the grants. Thus we find important heterogeneity in returns to investment and strong evidence that farmers with higher marginal returns to investment self-select into lending programs.
Sensor-Based Understanding of Daily Life via Large-Scale Use of Common Sense

The use of large quantities of common sense has long been thought to be critical to the automated understanding of the world. To this end, various groups have collected repositories of common sense in machine-readable form. However, efforts to apply these large bodies of knowledge to enable correspondingly large-scale sensor-based understanding of the world have been few. Challenges have included semantic gaps between facts in the repositories and phenomena detected by sensors, fragility of reasoning in the face of noise, incompleteness of repositories, and slowness of reasoning with these large repositories. We show how to address these problems with a combination of novel sensors, probabilistic representation, web-scale information retrieval and approximate reasoning. In particular, we show how to use the 50,000-fact hand-entered Open-Mind Indoor Common Sense database to interpret sensor traces of day-to-day activities with 88% accuracy (which is easy) and 32/53% precision/recall (which is not).
Sperm-carried RNAs play critical roles in mouse embryonic development

Recently, numerous studies have reported that the mature sperm contains both coding and non-coding RNAs and the sperm delivers some RNAs to the oocyte at fertilization. However, the functions of the RNAs carried to the oocyte by sperm at fertilization in embryonic development remains a mystery. In this study, the mature spermatozoa were treated with lysolecithin, pronase and RNases (RNase A and RNase H) to remove the sperm-carried RNAs, and then injected into normal mature oocyte. The results showed that after the treatment, the content of the sperm RNAs was decreased by about 90%. The blastocyst formation rate and the live birth rate of the embryos from intracytoplasmic sperm injection (ICSI) using the treated sperm were significantly decreased (P<0.01), while these effects were partially rescued by injecting total wide-type sperm RNAs. The reproductive capacity of offspring (F0) in sperm-treated group was similar with that in control group (P>0.05), but the body weight of F1 mice from sperm-treated group was lower than that in control group after two weeks of birth (P<0.05). These results demonstrated that the sperm-carried RNAs have important roles in embryonic development.
Geophysical evidence for a large impact structure on the Falkland (Malvinas) Plateau

A large, roughly circular structural basin is recognised on the Falkland (Malvinas) Plateau to the NW of West Falkland (Gran Malvina) Island (S 51°00′, W 62°00′). The basin, seen in seismic‐reflection profiles and evident as a large negative gravity anomaly, has a diameter of ~250 km. The age of the basin is estimated to be Late Palaeozoic. It is completely buried by younger sediments and has no topographic expression on the sea floor. We propose that the basin and geophysical anomalies, especially the combination of a large circular negative gravity anomaly with a rim of positive anomalies, and a marked circular series of positive magnetic anomalies in the same area, may be best explained by the presence of a large buried impact structure.
Surveillance-Activated Defenses Block the ROS–Induced Mitochondrial Unfolded Protein Response

Disturbance of cellular functions results in the activation of stress-signaling pathways that aim at restoring homeostasis. We performed a genome-wide screen to identify components of the signal transduction of the mitochondrial unfolded protein response (UPR(mt)) to a nuclear chaperone promoter. We used the ROS generating complex I inhibitor paraquat to induce the UPR(mt), and we employed RNAi exposure post-embryonically to allow testing genes whose knockdown results in embryonic lethality. We identified 54 novel regulators of the ROS-induced UPR(mt). Activation of the UPR(mt), but not of other stress-signaling pathways, failed when homeostasis of basic cellular mechanisms such as translation and protein transport were impaired. These mechanisms are monitored by a recently discovered surveillance system that interprets interruption of these processes as pathogen attack and depends on signaling through the JNK-like MAP-kinase KGB-1. Mutation of kgb-1 abrogated the inhibition of ROS-induced UPR(mt), suggesting that surveillance-activated defenses specifically inhibit the UPR(mt) but do not compromise activation of the heat shock response, the UPR of the endoplasmic reticulum, or the SKN-1/Nrf2 mediated response to cytosolic stress. In addition, we identified PIFK-1, the orthologue of the Drosophila PI 4-kinase four wheel drive (FWD), and found that it is the only known factor so far that is essential for the unfolded protein responses of both mitochondria and endoplasmic reticulum. This suggests that both UPRs may share a common membrane associated mechanism.
The use of verb-specific information for prediction in sentence processing

Recent research has shown that language comprehenders make predictions about upcoming linguistic information. These studies demonstrate that the processor not only analyses the input that it received but also predicts upcoming unseen elements. Two visual world experiments were conducted to examine the type of syntactic information this prediction process has access to. Experiment 1 examined whether the verb's subcategorisation information is used for predicting a direct object, by comparing transitive verbs (e.g., punish) to intransitive verbs (e.g., disagree). Experiment 2 examined whether verb frequency information is used for predicting a reduced relative clause by contrasting verbs that are infrequent in the past participle form (e.g., watch) with ones that are frequent in that form (e.g., record). Both experiments showed that comprehenders used lexically specific syntactic information to predict upcoming syntactic structure; this information can be used to avoid garden paths in certain cases, as Experiment 2 demonstrated.
A Hypothesis-based Dictionary Learning Model

Recent research in machine learning and signal processing has focused on modeling data with linear combinations of elements from learned dictionaries. We propose a hypothesis-based framework for classification tasks that classifies signals according to their structured dictionary representations. The framework considers that signal representations display different structures depending on their label information, and it makes hypotheses to analyze how likely a signal belongs to a particular class. The likelihood of belonging to a class is revealed by the patterns of representations on the dictionary, which allows for distinguishing signals from different categories. Additionally, our proposed framework is computationally more efficient than traditional sparse dictionaries. We validate the efficiency and performance of our framework on standard datasets used for evaluating dictionary learning models.
Evolving Multi-Layer Neural Networks for Othello

Othello has long been a favorite AI subject due to its very simple rules, its very low branching factor, its well defined strategic concepts and its dramatic changes in board topology as a game unfolds. In this paper, we investigate several neural network architectures using co-evolutionary learning techniques, with the objective to learn to play Othello strongly. Our resulting neural networks were able to learn to play the game at an expert-master level and to discover advanced strategies, within a few thousand generations, without any prior knowledge, beyond the game rules.
Recovery-promoting professional competencies: perspectives of mental health consumers, consumer-providers and providers.

OBJECTIVES The purpose of this study was to empirically validate a set of conceptually derived recovery-promoting competencies from the perspectives of mental health consumers, consumer-providers and providers. METHODS A national sample of 603 consumers, 153 consumer-providers and 239 providers completed an anonymous survey via the Internet. The survey evaluated respondents' perceptions about a set of 37 competencies hypothesized to enhance clients' hope and empowerment and inquired about interactions with providers that enhanced clients' recovery process. We used descriptive statistics and ranking to establish the relevance of each competency and generalized linear models and post-hoc tests to examine differences in the consumers', consumer-providers' and providers' assessments of these competencies. RESULTS Analyses confirmed the recovery relevance of several competencies and their relative importance within each group of study participants. They also revealed that while most competencies tended to have universal significance, others depended more strongly on the client's preferences. Finally, differences in the perceptions of consumers, consumer-providers and providers about the recovery relevance of these competencies were established. CONCLUSIONS AND IMPLICATIONS FOR PRACTICE The study highlighted the crucial role practitioners play in enhancing recovery from serious mental illnesses through specific strategies and attitudes that acknowledge clients' personhood and foster their hopefulness, empowerment and illness management. It informed the development of a new instrument measuring providers' recovery-promoting competence and provides guidelines for sharpening the recovery focus of a wide range of mental health and rehabilitation services.
Local infiltration analgesia in joint replacement: the evidence and recommendations for clinical practice

Relief of acute pain after hip and knee replacement represents a major therapeutic challenge as post‐operative pain hinders early mobilisation and rehabilitation with subsequent consequences on mobility, duration of hospitalisation and overall recovery. In recent years, there has been increased interest in high‐volume local wound infiltration/infusion techniques in these operations with a combined administration of local anaesthetics, NSAIDs and epinephrine. This review provides an update of the current knowledge of the efficacy of the high‐volume wound infiltration technique based on randomised trials. It is concluded that a predominant part of the data have had an insufficient design by not being placebo‐controlled or with comparable systemic analgesia provided in the investigated groups. It is concluded that there is little evidence to support the use of the technique in hip replacement either intraoperatively or with a post‐operative wound infusion catheter technique, provided that multimodal, oral non‐opioid analgesia is given. In knee replacement, the data support the intraoperative use of the local infiltration technique but not the post‐operative use of wound catheter administration. In knee replacement, a compression bandage prolongs the analgesic effect. There are limited data to support the use of NSAIDs or epinephrine in the solution and the data on post‐operative hospitalisation and recovery are conflicting. Thus, shorter lengths of stay have been achieved by oral multimodal, non‐opioid analgesia together with organisational optimisation of care according to the fast‐track methodology.
Melamine Cyanaurate Microrods Decorated with SnO2 Quantum Dots for Photoelectrochemical Applications

This study employs a simple and cost-effective technique to enhance the photoelectrochemical (PEC) water-splitting performance of melamine cyanaurate microrods (M), SnO2 nanostructures (S), and melamine cyanaurate microrods decorated with SnO2 quantum dots (MS) by optimizing NaOH and Na2SO3 electrolytes. Notably, the MS electrode demonstrates a remarkable improvement in PEC efficiency in Na2SO3 solution associated with NaOH solution. Specifically, the induced currents of the MS anode in the Na2SO3 electrolyte are approximately 6.28 mAcm−2 more than those observed in the NaOH electrolyte solution. It is revealed that SO32− anions effectively consume the holes, leading to improved separation of the generated charge pairs. This effective charge separation mechanism significantly contributes to the enhanced PEC performance observed in Na2SO3 electrolytes. The findings of this study suggest a capable approach for improving the PEC activity of the materials through the careful optimization of the supported electrolytes.
Skin conductance reactivity and respiratory sinus arrhythmia among maltreated and comparison youth: relations with aggressive behavior.

OBJECTIVE The goal of this study was to examine respiratory sinus arrhythmia (RSA), an indicator of parasympathetic nervous system-linked cardiac activity, and skin conductance level (SCL), a sympathetic indicator, as moderators of the link between child maltreatment and adolescent aggression. METHOD Participants were 234 maltreated (48.3% male) and 128 (57.8% male) comparison youth aged 9-16 years participating in wave 2 of a longitudinal study. RESULTS Regression analyses suggest that among boys, high RSA may be protective against the effects of maltreatment on aggressive behavior. Among girls, the moderating effect of RSA was further moderated by SCL reactivity such that low levels of both baseline RSA and SCL reactivity, or conversely high levels of both baseline RSA and SCL reactivity, exacerbated the link between maltreatment and aggression. CONCLUSIONS High RSA may protect against the effects of maltreatment on aggressive behavior, though this effect may be moderated by SCL reactivity among girls.