Miracle-dz/UniFAR-FTUs huggingface dataset:
Appreciation by supervisors buffers the impact of work interruptions on well-being longitudinally.

This study analyzed the effects of work interruptions as a stressor and appreciation of employees by supervisors as a resource with regard to four parameters of well-being, postulating main effects and interactions. Using latent moderated structural equation modeling, we analyzed longitudinal data on 208 employees at seven different companies who completed an online questionnaire twice. There were no main effects; however, the interactions between work interruptions and appreciation by supervisors were significant, and in the expected direction. Appreciation by supervisors moderated the effects of interruptions on the four parameters of employees’ well-being: job satisfaction, self-efficacy, job-related depressive mood, and sleep problems. These results held after accounting for conceptually relevant control variables, namely, time pressure, job control, and social support by supervisors. There were no indications for reversed effects. The findings underscore the importance of contextual factors like appreciative leader behavior for handling difficult situations such as work interruptions and thus confirm the potential of feeling appreciated at work as a protective resource in stressful work situations.
Neuroanatomical organization of perceptual memory: An fMRI study of picture priming

Neuroanatomical organization of perceptual representation in human memory system is unclear primarily because it has been studied using paradigms that have both, perceptual and conceptual components (e.g., word stem completion and word fragment completion). In the present experiment, functional magnetic resonance imaging (fMRI) technique was used to examine the pattern of cortical activation in a picture identification test in which subjects were asked to identify subliminally presented primed and novel pictures. This test is a modification of the word identification test that is considered a “pure” form of perceptual priming. Results indicate that perceptual priming is associated with reduced activation in the extrastriate cortex and that the memory for subliminally presented stimuli is processed by the same brain areas that process adequate stimuli. The activation pattern observed in picture identification test is different from that reported in the experiments of conceptual priming, suggesting that perceptual and conceptual representation of memory are supported by separate brain mechanisms. Hum. Brain Mapping 10:197–203, 2000. © 2000 Wiley‐Liss, Inc.
Transient Hyperintensity On Diffusion-Weighted MRI in Transient Global Amnesia

Objects: Different theories were suggested on the etiopathogenesis of transient global amnesia. Methods: We demonstrate a patient with transient global amnesia, in whom, a transient hyperintense signal change on left hippocampus was detected in diffusionand T2weighted magnetic resonance images. Conclusion: The absence of vascular risk factors or atherosclerotic changes in neuroimaging, in addition to transient lesion and antecedent migraine attack suggest the phenomenon of “spreading depression” secondary to migraine as underlying etiopathogenetic mechanism of transient global amnesia in this patient.
The possible impact of China's WTO membership on the WTO agricultural negotiations

Given China's impending membership of the WTO, this paper makes a first attempt to predict China's negotiating strategy in the current agricultural trade negotiations in the light of its food policy objectives, trade position and its accession offer on agriculture. China's interests with respect to market access are seen as closer to the EU position in the negotiations, while its interests regarding export subsidies, domestic supports and SPS issues are closer to the US position. Its specific negotiating objectives are unlikely to seriously threaten either US or EU interests, and China will be in a strong position to influence the final outcome by allying itself with whichever partner is most willing to accommodate its objectives.
Local Application of Sodium Salicylate Enhances Auditory Responses in the Rat’s Dorsal Cortex of the Inferior Colliculus

Sodium salicylate (SS) is a widely used medication with side effects on hearing. In order to understand these side effects, we recorded sound-driven local-field potentials in a neural structure, the dorsal cortex of the inferior colliculus (ICd). Using a microiontophoretic technique, we applied SS at sites of recording and studied how auditory responses were affected by the drug. Furthermore, we studied how the responses were affected by combined local application of SS and an agonists/antagonist of the type-A or type-B γ-aminobutyric acid receptor (GABAA or GABAB receptor). Results revealed that SS applied alone enhanced auditory responses in the ICd, indicating that the drug had local targets in the structure. Simultaneous application of the drug and a GABAergic receptor antagonist synergistically enhanced amplitudes of responses. The synergistic interaction between SS and a GABAA receptor antagonist had a relatively early start in reference to the onset of acoustic stimulation and the duration of this interaction was independent of sound intensity. The interaction between SS and a GABAB receptor antagonist had a relatively late start, and the duration of this interaction was dependent on sound intensity. Simultaneous application of the drug and a GABAergic receptor agonist produced an effect different from the sum of effects produced by the two drugs released individually. These differences between simultaneous and individual drug applications suggest that SS modified GABAergic inhibition in the ICd. Our results indicate that SS can affect sound-driven activity in the ICd by modulating local GABAergic inhibition.
Dynamic rays of bounded-type entire functions

We construct an entire function in the Eremenko-Lyubich class B whose Julia set has only bounded path-components. This answers a question of Eremenko from 1989 in the negative. On the other hand, we show that for many functions in B, in particular those of nite order, every escaping point can be connected to 1 by a curve of escaping points. This gives a partial positive answer to the aforementioned question of Eremenko, and answers a question of Fatou from 1926.
Notice of RetractionThree positive solutions of nonlinear boundary value problems with sign changing nonlinearity

In this paper, we study the existence of positive solutions for a class nonlinear boundary value problem { (Φp(u'))'+ a(t)f(u) = 0, 0 <; t <; 1, u'(0) =u(1) = 0, Φp(s)= |s|p-2s, p>1. We obtain the existence of three positive solutions by using Leggett-Williams fixed-point theorem in a cone. Especially, the nonlinear terms f is allowed to change sign. The conclusions in this paper essentially extend and improve the known results.
Cancer DNA Methylation: Molecular Mechanisms and Clinical Implications

DNA methylation plays a crucial role in the regulation of gene expression and chromatin organization within normal eukaryotic cells. In cancer, however, global patterns of DNA methylation are altered with global hypomethylation of repeat-rich intergenic regions and hypermethylation of a subset of CpG-dense gene-associated regions (CpG islands). Extensive research has revealed the cellular machinery that catalyzes DNA methylation, as well as several large protein complexes that mediate the transcriptional repression of hypermethylated genes. However, research is only just beginning to uncover the molecular mechanisms underlying the origins of cancer-specific DNA methylation. Herein, we present several recent advances regarding these mechanisms and discuss the relationship between histone modifications (i.e., H3K4me2/3, H4K16Ac, H3K9me2/3, H3K27me3, H4K20me3), chromatin-modifying enzymes (G9a, EZH2, hMOF, SUV4-20H), and aberrant DNA methylation. Additionally, the role played by inflammation, DNA damage, and miRNAs in the etiology of aberrant DNA methylation is considered. Finally, we discuss the clinical implications of aberrant DNA methylation and the utility of methylated biomarkers in cancer diagnosis and management.
Transcriptional and Functional Analysis of Oxalyl-Coenzyme A (CoA) Decarboxylase and Formyl-CoA Transferase Genes from Lactobacillus acidophilus

ABSTRACT Oxalic acid is found in dietary sources (such as coffee, tea, and chocolate) or is produced by the intestinal microflora from metabolic precursors, like ascorbic acid. In the human intestine, oxalate may combine with calcium, sodium, magnesium, or potassium to form less soluble salts, which can cause pathological disorders such as hyperoxaluria, urolithiasis, and renal failure in humans. In this study, an operon containing genes homologous to a formyl coenzyme A transferase gene (frc) and an oxalyl coenzyme A decarboxylase gene (oxc) was identified in the genome of the probiotic bacterium Lactobacillus acidophilus. Physiological analysis of a mutant harboring a deleted version of the frc gene confirmed that frc expression specifically improves survival in the presence of oxalic acid at pH 3.5 compared with the survival of the wild-type strain. Moreover, the frc mutant was unable to degrade oxalate. These genes, which have not previously been described in lactobacilli, appear to be responsible for oxalate degradation in this organism. Transcriptional analysis using cDNA microarrays and reverse transcription-quantitative PCR revealed that mildly acidic conditions were a prerequisite for frc and oxc transcription. As a consequence, oxalate-dependent induction of these genes occurred only in cells first adapted to subinhibitory concentrations of oxalate and then exposed to pH 5.5. Where genome information was available, other lactic acid bacteria were screened for frc and oxc genes. With the exception of Lactobacillus gasseri and Bifidobacterium lactis, none of the other strains harbored genes for oxalate utilization.
Evaluating contextually adapted reading interventions with third-grade, Costa Rican students experiencing significant reading difficulties

Scholarship in school psychology has continued to document the need and importance of contextually relevant intervention and prevention research, but this type of research remains relatively scarce. Also problematic, this type of research is even more limited in low- and middle-income countries (LMIC) compared to high-income countries. This situation within school psychology scholarship not only has negative implications for research and practice, it also limits internationalization within the discipline. The geographical context for the present study was in Costa Rica, currently a Latin American LMIC. Given the global importance of literacy, this article describes an experimental evaluation comparing two time- and resource-efficient reading interventions that differed only by instructional grouping: A one-on-one intervention, and an even more resource-efficient small-group intervention. Participants included third-graders experiencing significant reading difficulties. Analyses showed that all students benefitted from intervention, but some students responded somewhat more favorably to one intervention versus the other. Limitations, implications, and future research directions are discussed, particularly within the context of international school psychology and how professionals in the discipline can benefit from more intervention research in otherwise underrepresented global regions.
Cutaneous Structural and Biochemical Correlates of Foot Complications in High-Risk Diabetes

OBJECTIVE Impairment of skin quality may contribute to diabetic foot ulceration (DFU). Our goal was to determine whether high-risk patients exhibited specific skin structural and metabolic deficits that could predispose to foot complications. RESEARCH DESIGN AND METHODS A total of 46 patients comprising 9 diabetic control subjects, 16 with diabetic peripheral neuropathy (DPN) alone, and 21 with recurrent DFUs (including 9 with Charcot neuroarthropathy [CNA]) were recruited and compared with 14 nondiabetic control (NDC) subjects. DPN was assessed using the Michigan Neuropathy Screening Instrument (MNSI). Skin punch biopsies (3 mm) were performed on upper and lower leg skin for measurements of intraepidermal nerve fiber density (IENFD), structural analysis, type 1 procollagen abundance, tissue degrading matrix metalloproteinases (MMPs), and poly(ADP-ribose) (PAR) immunoreactivity. RESULTS MNSI scores were comparable across DPN groups. IENFD was decreased by diabetes and DPN but did not differ between neuropathic groups. Skin structural deficit scores were elevated in all neuropathic subjects, particularly in the DFU group. Type 1 procollagen abundance was reduced in DFU subjects 387 ± 256 units (mean ± 1 SD) compared with NDC subjects (715 ± 100, P < 0.001). MMP-1 and MMP-2 were activated by diabetes. PAR immunoreactivity was increased in DFU (particularly in the CNA group; P < 0.01) compared with other DPN subjects. CONCLUSIONS Increased PAR, reduced type 1 procollagen abundance, and impaired skin structure are associated with foot complications in diabetes. The potential of therapies that improve skin quality to reduce DFU needs to be investigated.
A Robust Reputation System for Mobile Ad-hoc Networks

Reputation systems in mobile ad-hoc networks can be tricked by the spreading of false reputation ratings, be it false accusations or false praise. Simple solutions such as exclusively relying on one`s own direct observations have drawbacks, as they do not make use of all the information available. We propose a fully distributed reputation system that can cope with false disseminated information. In our approach, everyone maintains a reputation rating and a trust rating about everyone else that they care about. From time to time first-hand reputation information is exchanged with others; using a modified Bayesian approach we designed and present in this paper, only second-hand reputation information that is not incompatible with the current reputation rating is accepted. Thus, reputation ratings are slightly modified by accepted information. Trust ratings are updated based on the compatibility of second-hand reputation information with prior reputation ratings. Data is entirely distributed: someone`s reputation and trust is the collection of ratings maintained by others. We enable node redemption and prevent the sudden exploitation of good reputation built over time by introducing re-evaluation and reputation fading. We present the application of our generic reputation system to the context of neighborhood watch in mobile ad-hoc networks, specifically to the CONFIDANT \cite{buchegger:performance} protocol for the detection and isolation of nodes exhibiting routing or forwarding misbehavior. We evaluate the performance by simulation.
Love of money, gender, religiosity: The impact on ethical perceptions of future professional accountants

Accountants are either directly or indirectly partly responsible for corporate frauds, so it is important to know the underlying reasons why such unethical behavior occurred. This study aims to analyze the moderation impact of religiosity and gender on the relation between love of money with student’s ethical perception. There were 144 questionnaires from accounting students. As hypothesized, the results of the study revealed love of money have a negative impact to student’s ethical perception. The interaction between intrinsic religiosity and love of money are able to weaken the negative effect of love of money to student’s ethical perception, however the extrinsic religiosity is vice versa. Gender has no significant effect on love of money relationship with ethical perception.
Ceramide-1-phosphate inhibits cigarette smoke-induced airway inflammation

Sphingolipids are involved in the pathogenesis of inflammatory diseases. The central molecule is ceramide, which can be converted into ceramide-1-phosphate (C1P). Although C1P can exert anti- and pro-inflammatory effects, its influence on cigarette smoke (CS)-induced lung inflammation is unknown. We aimed to clarify the role of C1P in the pathogenesis of CS-triggered pulmonary inflammation and emphysema in humans and mice. The effects of C1P were addressed on CS-induced lung inflammation in C57BL/6 mice, CS extract-triggered activation of human airway epithelial cells (AECs) and neutrophils from patients with chronic obstructive pulmonary disease. Differential cell counts in bronchoalveolar lavage fluid were determined by flow cytometry and pro-inflammatory cytokines were measured by ELISA. Expression and DNA binding of nuclear factor (NF)-κB and neutral sphingomyelinase (nSMase) were quantified by PCR, electrophoretic mobility shift and fluorometric assays. C1P reduced CS-induced acute and chronic lung inflammation and development of emphysema in mice, which was associated with a reduction in nSMase and NF-κB activity in the lungs. nSMase activity in human serum correlated negatively with forced expiratory volume in 1 s % predicted. In human AECs and neutrophils, C1P inhibited CS-induced activation of NF-κB and nSMase, and reduced pro-inflammatory cytokine release. Our results suggest that C1P is a potential target for anti-inflammatory treatment in CS-induced lung inflammation. Ceramide-1-phosphate, a potential target for anti-inflammatory treatment in cigarette smoke-induced lung inflammation http://ow.ly/E7tUS
On modeling of information retrieval concepts in vector spaces

The Vector Space Model (VSM) has been adopted in information retrieval as a means of coping with inexact representation of documents and queries, and the resulting difficulties in determining the relevance of a document relative to a given query. The major problem in employing this approach is that the explicit representation of term vectors is not known a priori. Consequently, earlier researchers made the assumption that the vectors corresponding to terms are pairwise orthogonal. Such an assumption is clearly unrealistic. Although attempts have been made to compensate for this assumption by some separate, corrective steps, such methods are ad hoc and, in most cases, formally inconsistent. In this paper, a generalization of the VSM, called the GVSM, is advanced. The developments provide a solution not only for the computation of a measure of similarity (correlation) between terms, but also for the incorporation of these similarities into the retrieval process. The major strength of the GVSM derives from the fact that it is theoretically sound and elegant. Furthermore, experimental evaluation of the model on several test collections indicates that the performance is better than that of the VSM. Experiments have been performed on some variations of the GVSM, and all these results have also been compared to those of the VSM, based on inverse document frequency weighting. These results and some ideas for the efficient implementation of the GVSM are discussed.
Identification of Potential Recombination Breakpoints in Human Parechoviruses

ABSTRACT Based on a comparison of the phylogeny of two distant regions, evidence has been found for recombination within parechoviruses. However, recombination breakpoints could not be detected in this way. We searched for potential recombination breakpoints in parechovirus by analysis of complete parechovirus sequences, including a newly isolated strain. Bootscan analysis demonstrated that parechoviruses are mosaic viruses build of regions related to corresponding genomic regions of other parechoviruses. With a genetic algorithm for recombination detection, sites for recombination were found. Analysis of partial sequences, as defined by recombination breakpoints, showed phylogenetic segregation between regions.
Functional Consequences of the Disturbances in the GABA-Mediated Inhibition Induced by Injuriesin the Cerebral Cortex

Cortical injuries are often reported to induce a suppression of the intracortical GABAergic inhibition in the surviving, neighbouring neuronal networks. Since GABAergic transmission provides the main source of inhibition in the mammalian brain, this condition may lead to hyperexcitability and epileptiform activity of cortical networks. However, inhibition plays also a crucial role in limiting the plastic properties of neuronal circuits, and as a consequence, interventions aiming to reestablish a normal level of inhibition might constrain the plastic capacity of the cortical tissue. A promising strategy to minimize the deleterious consequences of a modified inhibitory transmission without preventing the potential beneficial effects on cortical plasticity may be to unravel distinct GABAergic signaling pathways separately mediating these positive and negative events. Here, gathering data from several recent studies, we provide new insights to better face with this “double coin” condition in the attempt to optimize the functional recovery of patients.
Ventricular Atrial Natriuretic Factor in the Cardiomyopathic Hamster Model of Congestive Heart Failure

Cardiac atria are thought to be the principle source of plasma atrial natriuretic factor (ANF), a potent natriuretic and diuretic peptide. Whether other ANF production sites are recruited in disease states exhibiting elevated plasma ANF levels is not known. Accordingly, in the cardiomyopathic hamster, an animal model of congestive heart failure with high circulating levels of ANF, contribution of ventricular tissue to total cardiac ANF production and storage was investigated. Measurements were made of immunoreactive ANF in plasma and in atrial and ventricular extracts as well as ANF mRNA levels in the atria and ventricles from normal and cardiomyopathic golden Syrian hamsters. Plasma ANF levels were higher in cardiomyopathic than in control animals. The atrial concentration of ANF (per milligram atrial weight) was 50% and 83% lower hi moderate and severe congestive heart failure, respectively, when compared with controls, while atrial ANF mRNA content of cardiomyopathic hamsters was not significantly different from normal hamsters. The ventricular concentration of ANF was 3 times and 7 times higher in animals in moderate and severe heart failure when compared with controls. In severe heart failure, ventricular ANF accounted for 23% of total cardiac stores of ANF. Ventricular ANF mRNA levels were 7 tunes and 13 times higher in hamsters in moderate and severe heart failure as compared with control animals. Therefore, significant increases in both ANF content and ANF mRNA in ventricles of hamsters in moderate to severe heart failure suggest that the ventricle could be an important source of ANF in congestive heart failure.
Compression of Deep Convolutional Neural Networks for Fast and Low Power Mobile Applications

Although the latest high-end smartphone has powerful CPU and GPU, running deeper convolutional neural networks (CNNs) for complex tasks such as ImageNet classification on mobile devices is challenging. To deploy deep CNNs on mobile devices, we present a simple and effective scheme to compress the entire CNN, which we call one-shot whole network compression. The proposed scheme consists of three steps: (1) rank selection with variational Bayesian matrix factorization, (2) Tucker decomposition on kernel tensor, and (3) fine-tuning to recover accumulated loss of accuracy, and each step can be easily implemented using publicly available tools. We demonstrate the effectiveness of the proposed scheme by testing the performance of various compressed CNNs (AlexNet, VGGS, GoogLeNet, and VGG-16) on the smartphone. Significant reductions in model size, runtime, and energy consumption are obtained, at the cost of small loss in accuracy. In addition, we address the important implementation level issue on 1? 1 convolution, which is a key operation of inception module of GoogLeNet as well as CNNs compressed by our proposed scheme.