Miracle-dz/UniFAR-FTUs huggingface dataset:
Anesthesiologist's satisfaction using between cisatracurium and rocuronium for the intubation in the anesthesia induced by remifentanil and propofol

Background Although cisatracurium has many advantages in anesthetic practices, the best choice of a nondepolarizing neuromuscular blocking agent that can replace succinylcholine is rocuronium. However, it is reported that remifentanil with propofol might provide reliable intubating condition, even without a neuromuscular blocking agent; therefore, it might improve the intubating condition with cisatracurium. This study examined intubating conditions after administering rocuronium or cisatracurium in a rapid sequence induction with remifentanil-propofol. Methods Fifty two ASA physical status 1 or 2 adult patients scheduled for an elective surgery were enrolled in a randomized double-blinded trial. Anesthesia was induced in all patients with propofol 2.0 mg/kg and remifentanil 0.5 µg/kg, administered over 60 seconds. Rocuronium 0.9 mg/kg (3 × ED95, R group, n = 23) or cisatracurium 0.15 mg/kg (3 × ED95, C group, n = 29) was administered after the induction sequence. Laryngoscopy was attempted when the anesthesiologist thought it was 90 seconds after drug administration and appropriate time for intubation. The examiner, another anesthesiologist, recorded the exact time to intubation and suppression of maximal T1 on TOF. The intubating condition was assessed by the first anesthesiologist, as excellent, good, poor or not possible. Results The best time to laryngoscopy was predicted by measuring TOF and was found to be significantly longer in the C group (197 ± 53 s) than in the R group (102 ± 49 s) (P value < 0.05). However, time to larygoscopy, intubating condition during the laryngoscopy, and hemodynamic changes after intubation was similar in both groups. Conclusions Despite fundamentally slower onset time, cisatracurium can provide quite good intubating conditions, which were comparable to those achieved with equipotent doses of rocuronium, which is more expensive in anesthesia inducted with remifentanil and propofol.
Transforming Growth Factor β Receptor Type 1 Is Essential for Female Reproductive Tract Integrity and Function

The transforming growth factor β (TGFβ) superfamily proteins are principle regulators of numerous biological functions. Although recent studies have gained tremendous insights into this growth factor family in female reproduction, the functions of the receptors in vivo remain poorly defined. TGFβ type 1 receptor (TGFBR1), also known as activin receptor-like kinase 5, is the major type 1 receptor for TGFβ ligands. Tgfbr1 null mice die embryonically, precluding functional characterization of TGFBR1 postnatally. To study TGFBR1–mediated signaling in female reproduction, we generated a mouse model with conditional knockout (cKO) of Tgfbr1 in the female reproductive tract using anti-Müllerian hormone receptor type 2 promoter-driven Cre recombinase. We found that Tgfbr1 cKO females are sterile. However, unlike its role in growth differentiation factor 9 (GDF9) signaling in vitro, TGFBR1 seems to be dispensable for GDF9 signaling in vivo. Strikingly, we discovered that the Tgfbr1 cKO females develop oviductal diverticula, which impair embryo development and transit of embryos to the uterus. Molecular analysis further demonstrated the dysregulation of several cell differentiation and migration genes (e.g., Krt12, Ace2, and MyoR) that are potentially associated with female reproductive tract development. Moreover, defective smooth muscle development was also revealed in the uteri of the Tgfbr1 cKO mice. Thus, TGFBR1 is required for female reproductive tract integrity and function, and disruption of TGFBR1–mediated signaling leads to catastrophic structural and functional consequences in the oviduct and uterus.
Platelet-Rich Plasma for Patellar Tendinopathy: A Randomized Controlled Trial of Leukocyte-Rich PRP or Leukocyte-Poor PRP Versus Saline

Background: A small number of randomized controlled trials have found ultrasound-guided injection of platelet-rich plasma (PRP) to be no more effective than saline for several tendinopathies; limited information exists for patellar tendinopathy. In addition, different PRP formulations that produce varying concentrations of leukocytes have not been directly compared for patellar tendinopathy. Purpose/Hypothesis: To determine if a single ultrasound-guided PRP injection, either leukocyte-rich PRP (LR-PRP) or leukocyte-poor PRP (LP-PRP), was superior to saline injection for the treatment of patellar tendinopathy. The null hypothesis was that no treatment would be superior to another for the treatment of patellar tendinopathy. Study Design: Randomized controlled trial; Level of evidence, 1. Methods: Athletes with patellar tendinopathy for ≥6 months (Blazina stage IIIB) were assessed for eligibility in a multisite single-blind controlled trial. There were 3 injection arms: LR-PRP, LP-PRP, and saline. Patients received a single ultrasound-guided injection, followed by 6 weeks of supervised rehabilitation (heavy slow resistance training, concentric and eccentric, 3 times per week). Outcome measures—Victorian Institute of Sport Assessment (patellar; VISA-P), pain during activity, and global rating of change—were assessed at 6 and 12 weeks and 6 and 12 months. VISA-P score at 12 weeks was the primary outcome. Fifty-seven patients (19 in each group) were included in an intention-to-treat analysis. Secondary outcome measures included pain during activity and patients’ global rating of change. Results: Study retention was 93% at 12 weeks and 79% after 1 year. There was no significant difference in mean change in VISA-P score, pain, or global rating of change among the 3 treatment groups at 12 weeks or any other time point. After 1 year, the mean (SD) outcomes for the LR-PRP, LP-PRP, and saline groups were as follows, respectively: VISA-P—58 (29), 71 (20), and 80 (18); pain—4.0 (2.4), 2.4 (2.3), and 2.0 (1.9); global rating of change—4.7 (1.6), 5.6 (1.0), and 5.7 (1.2) (P > .05 for all outcomes). Conclusion: Combined with an exercise-based rehabilitation program, a single injection of LR-PRP or LP-PRP was no more effective than saline for the improvement of patellar tendinopathy symptoms. Registration: NCT02116946 (ClinicalTrials.gov identifier).
Heterochromatic Silencing and HP1 Localization in Drosophila Are Dependent on the RNAi Machinery

Genes normally resident in euchromatic domains are silenced when packaged into heterochromatin, as exemplified in Drosophila melanogaster by position effect variegation (PEV). Loss-of-function mutations resulting in suppression of PEV have identified critical components of heterochromatin, including proteins HP1, HP2, and histone H3 lysine 9 methyltransferase. Here, we demonstrate that this silencing is dependent on the RNA interference machinery, using tandem mini-white arrays and white transgenes in heterochromatin to show loss of silencing as a result of mutations in piwi, aubergine, or spindle-E (homeless), which encode RNAi components. These mutations result in reduction of H3 Lys9 methylation and delocalization of HP1 and HP2, most dramatically in spindle-E mutants.
Robust Optimization of EV Charging Schedules in Unregulated Electricity Markets

In this paper, we address the problem of optimal electric vehicle (EV) charging in an unregulated electricity market. This problem is known to be highly nonlinear even in the case of fixed electricity prices due to a nonlinear state-of-charge curve representing physical battery limitations. We design tractable formulations for single and multiple EV charging frameworks. In the first part of this paper, we develop a new efficient cutting plane method, that can be used for solving charging optimization problem for both scenarios of known and uncertain electricity prices. The latter scenario with real-time electricity rates is considered in the second part of this paper. We obtain robust optimization counterparts of the nominal charging problems that are particularly important from an economic perspective when budget constraints are strictly enforced. New robust formulations are proven to be tractable. Moreover, computational experiments illustrate that a decision maker can find solutions that are close to optimal in terms of the corresponding objective values, and robust with respect to uncertain electricity prices.
A human macrophage‐associated antigen (CD68) detected by six different monoclonal antibodies

Summary. Antibodies grouped together by the Third Workshop on Leucocyte Differentiation Antigens on the basis of pan‐macrophage reactivity on tissue sections were analysed in immunoprecipitation experiments. Antibodies Y2/131. EBM11, Ki‐M6 and Ki‐M7 all precipitated antigens of Mr 110000 which were shown to be identical by preclearing experiments. In addition a recently produced antibody, KP1, which identifies macrophages in paraffin‐embedded tissue, was shown to recognize the same antigen. The antibodies were tested on murine cells transfected with two clones, which had been isolated by screening a cDNA library with antibodies Y1/82A and EBM11. Cells transfected with the longer cDNA clone, coding for a molecule of Mr 110000, reacted with antibodies Y2/131. EBM11. Y1/82A and Ki‐M6, whilst the shorter clone, encoding a molecule of Mr 70000 gave the same result except that it did not induce expression of the Ki‐M6 epitope. KP1 antibody did not recognize any transfectants, possibly because of differences in glycosylation by the transfected cell line compared with human tissue. Five of the six antibodies appear to recognize different epitopes (the sixth, Ki‐M7, not having been evaluated in this way). It was concluded that these six antibodies react with a macrophage‐associated antigen for which the gene has been cloned. This group of antibodies has recently been designated CD68 by the Fourth Workshop on Human Leucocyte Differentiation Antigens.
Residential Exposure to Outdoor Air Pollution during Pregnancy and Anthropometric Measures at Birth in a Multicenter Cohort in Spain

Background: A growing body of research suggests that prenatal exposure to air pollution may be harmful to fetal development. We assessed the association between exposure to air pollution during pregnancy and anthropometric measures at birth in four areas within the Spanish Children’s Health and Environment (INMA) mother and child cohort study. Methods: Exposure to ambient nitrogen dioxide (NO2) and benzene was estimated for the residence of each woman (n = 2,337) for each trimester and for the entire pregnancy. Outcomes included birth weight, length, and head circumference. The association between residential outdoor air pollution exposure and birth outcomes was assessed with linear regression models controlled for potential confounders. We also performed sensitivity analyses for the subset of women who spent more time at home during pregnancy. Finally, we performed a combined analysis with meta-analysis techniques. Results: In the combined analysis, an increase of 10 µg/m3 in NO2 exposure during pregnancy was associated with a decrease in birth length of –0.9 mm [95% confidence interval (CI), –1.8 to –0.1 mm]. For the subset of women who spent ≥ 15 hr/day at home, the association was stronger (–0.16 mm; 95% CI, –0.27 to –0.04). For this same subset of women, a reduction of 22 g in birth weight was associated with each 10-µg/m3 increase in NO2 exposure in the second trimester (95% CI, –45.3 to 1.9). We observed no significant relationship between benzene levels and birth outcomes. Conclusions: NO2 exposure was associated with reductions in both length and weight at birth. This association was clearer for the subset of women who spent more time at home.
Stochastic simulation of enzymatic reactions under transcriptional feedback regulation

The interaction between gene expression and metabolism is a form of feedback control that allows cells to up- or downregulate specific reactions according to the environmental conditions. Although gene expression is an inherently stochastic process, the effect of genetic feedback on the propagation of noise to the metabolic layer remains largely unexplored. These systems operate in two timescales, and a major challenge is to devise stochastic simulation techniques that can cope with this stiffness in reasonable computational time. We propose a simulation technique, based on the slow-scale Stochastic Simulation Algorithm, to rapidly compute realizations of the Markov process associated to an enzymatic reaction under genetic feedback regulation. We show that in the case of constant substrate, the enzyme-substrate complexes have a binomial stationary distribution. With this result we can avoid the explicit simulation of the binding/dissociation of the enzyme and substrate, leading to a significant improvement in computational speed. We discuss the extension of the algorithm to networks of enzymatic reactions. The proposed method can be used to systematically compute the stationary distributions of the species for different combinations of model parameters, thus opening the way for the identification of the cellular processes that can modulate the amplification or attenuation of genetic noise in enzymatic reactions.
Categorization and characterization of transcript-confirmed constitutively and alternatively spliced introns and exons from human.

By spliced alignment of human DNA and transcript sequence data we constructed a data set of transcript-confirmed exons and introns from 2793 genes, 796 of which (28%) were seen to have multiple isoforms. We find that over one-third of human exons can translate in more than one frame, and that this is highly correlated with G+C content. Introns containing adenosine at donor site position +3 (A3), rather than guanosine (G3), are more common in low G+C regions, while the converse is true in high G+C regions. These two classes of introns are shown to have distinct lengths, consensus sequences and correlations among splice signals, leading to the hypothesis that A3 donor sites are associated with exon definition, and G3 donor sites with intron definition. Minor classes of introns, including GC-AG, U12-type GT-AG, weak, and putative AG-dependant introns are identified and characterized. Cassette exons are more prevalent in low G+C regions, while exon isoforms are more prevalent in high G+C regions. Cassette exon events outnumber other alternative events, while exon isoform events involve truncation twice as often as extension, and occur at acceptor sites twice as often as at donor sites. Alternative splicing is usually associated with weak splice signals, and in a majority of cases, preserves the coding frame. The reported characteristics of constitutive and alternative splice signals, and the hypotheses offered regarding alternative splicing and genome organization, have important implications for experimental research into RNA processing. The 'AltExtron' data sets are available at http://www.bit. uq.edu. au/altExtron/ and http://www.ebi. ac.uk/~thanaraj/altExtron/.
Dramatic Play Affordances of Natural and Manufactured Outdoor Settings for Preschool-Aged Children

Concern for child wellness has led play professionals to explore natural playscapes as a means to enhance free play and consequently child development. For preschool-aged children, dramatic play is a particularly valuable free play that advances cognitive skills, social skills, and emotional intelligence. This study compared thedramatic play affordances of natural and manufactured outdoor play settings to determine which afford the most dramatic play for preschool-aged children. Twenty-four 3- to 5- year-olds were observed during daily playtime on a “natural playground” and an equipment-based “manufactured playground. ” Behavior mapping identified settings that afforded the most solitary dramatic, sociodramatic, and complex sociodramatic play. The study suggests that environments designed with child-scale constructive play props, a sense of enclosure, and natural surroundings are more likely to support complex dramatic play. Intentional inclusion of these design elements may afford greater dramatic play in the preschool play yard.
CAUSAL UNCERTAINTY AND SELF-REGULATION ABILITIES

ii CO-AUTHORSHIP iv ACKNOWLEDGMENTS v TABLE OF CONTENTS vi LIST OF FIGURES ix CHAPTER 1 GENERAL INTRODUCTION 1 The Strength Model 2 Self-Regulation and Social Relationships 4 Self-Regulation and Personality: The Case of Causal Uncertainty . 6 Cognitive and Social Concomitants and Consequences of Causal Uncertainty.10 The Current Studies 13 CHAPTER 2: STUDY 1 EXPECTATIONS OF FUTURE SELF-CONTROL FOLLOWING SOCIAL AND NONSOCIAL TASKS 17 Method 19 Participants 19 Materials 20 Procedure 22 Results 25 Manipulation Check 25 Regression Analysis 26 Social Condition Effects 27 Nonsocial Condition Effects 31
The Effects of Soy Bean Flour Enriched Bread Intake on Anthropometric Indices and Blood Pressure in Type 2 Diabetic Women: A Crossover Randomized Controlled Clinical Trial

Previous studies showed that soy bean has the potential to improve many aspects of diabetes state and provide metabolic benefits that aid in weight management. We aimed to determine the effects of soy bean flour enriched bread on anthropometric indices and blood pressure among type 2 diabetic patients. This randomized, crossover, clinical trial was performed in 30 type 2 diabetic women. There were two trial periods for 6 weeks and a wash-out period for 4 weeks. In the soy bread diet period, 120 g of soy bean flour enriched bread was consumed each day instead of the same amount of their usual bread or other cereal products. After a 4-week wash-out period, participants were crossed over for another 6 weeks. Mean (±SD) age of study participants was 45.7 ± 3.8 years. The results of our study showed no significant effects of soy bean flour enriched bread on anthropometric indices and blood pressure among diabetic patients. Despite the slight reduction in BMI, waist circumference, and percent of body fat, there were no significant differences in changes of these values between two groups. No significant changes in waist to hip ratio and blood pressure were seen.
Evaluation of the Hardware for a Mobile Measurement Station

This paper presents a specific approach to the design of a mobile measurement station (MMS) that will operate in a harsh environment. This paper also presents a selection process for the hardware of the MMS. The work is based on a quality engineering method called the quality function deployment and on an operations research tool called the analytic hierarchy process. These approaches have not found a widespread application in the design of measurement systems. An important part of this paper is the selection of a controller for the MMS, for which the authors describe two engineering tools for the selection procedure. Most engineering designs can benefit from using these two engineering tools for selecting components.
Cyanobacterial clock, a stable phase oscillator with negligible intercellular coupling

Accuracy in cellular function has to be achieved despite random fluctuations (noise) in the concentrations of different molecular constituents inside and outside the cell. The circadian oscillator in cyanobacteria is an example of resilience to noise. This resilience could be either the consequence of intercellular communication or the intrinsic property of the built-in biochemical network. Here we investigate the intercellular coupling hypothesis. A short theoretical depiction of interacting noisy phase oscillators, confirmed by numerical simulations, allows us to discriminate the effect of coupling from noise. Experimentally, by studying the phase of concurrent populations of different initial phases, we evaluate a very small upper limit of the intercellular coupling strength. In addition, in situ entrainment experiments confirm our ability to detect a coupling of the circadian oscillator to an external force and to describe explicitly the dynamic change of the mean phase. We demonstrate, therefore, that the cyanobacterial clock stability is a built-in property as the intercellular coupling effect is negligible.
Mapping the asymmetrical citation relationships between journals by h‐plots

I propose the use of h‐plots for visualizing the asymmetric relationships between the citing and cited profiles of journals in a common map. With this exploratory tool, we can understand better the journal's dual roles of citing and being cited in a reference network. The h‐plot is introduced and its use is validated with a set of 25 journals belonging to the statistics area. The relatedness factor is considered for describing the relations of citations from a journal “i” to a journal “j,” and the citations from the journal “j” to the journal “i. ” More information has been extracted from the h‐plot, compared with other statistical techniques for modelling and representing asymmetric data, such as multidimensional unfolding.
Observation of critical phenomena and self-similarity in the gravitational collapse of radiation fluid

We observe critical phenomena in spherical collapse of radiation fluid. A sequence of spacetimes $\cal{S}[\eta]$ is numerically computed, containing models ($\eta\ll 1$) that adiabatically disperse and models ($\eta\gg 1$) that form a black hole. Near the critical point ($\eta_c$), evolutions develop a self-similar region within which collapse is balanced by a strong, inward-moving rarefaction wave that holds $m(r)/r$ constant as a function of a self-similar coordinate $\xi$. The self-similar solution is known and we show near-critical evolutions asymptotically approaching it. A critical exponent $\beta \simeq 0.36$ is found for supercritical ($\eta>\eta_c$) models.
The Economics and Politics of Women's Rights

Women’s rights and economic development are highly correlated. Today, the discrepancy between the legal rights of women and men is much larger in developing compared to developed countries. Historically, even in countries that are now rich women had few rights before economic development took off. Is development the cause of expanding women’s rights, or conversely, do women’s rights facilitate development? We argue that there is truth to both hypotheses. The literature on the economic consequences of women’s rights documents that more rights for women lead to more spending on health and children, which should benefit development. The politicaleconomy literature on the evolution of women’s rights finds that technological change increased the costs of patriarchy for men, and thus contributed to expanding women’s rights. Combining these perspectives, we discuss the theory of Doepke and Tertilt (2009), where an increase in the return to human capital induces men to vote for women’s rights, which in turn promotes growth in human capital and income per capita.