Miracle-dz/UniFAR-FTUs huggingface dataset:
Ten Year Trends in Community HIV Viral Load in Barbados: Implications for Treatment as Prevention

Background Treatment as prevention is a paradigm in HIV medicine which describes the public health benefit of antiretroviral therapy (ART). It is based on research showing substantial reductions in the risk of HIV transmission in persons with optimally suppressed HIV-1 Viral Loads (VL). The present study describes ten year VL trends at the national HIV treatment unit and estimates VL suppression at a population level in Barbados, a Caribbean island with a population of 277,000, an estimated adult HIV prevalence of 1.2%, and served by a single treatment unit. Methods The national HIV treatment centre of the Barbados Ministry of Health has a client VL database extending back to inception of the clinic in 2002 (n = 1,462 clients, n = 17,067 VL measurements). Optimal VL suppression was defined at a threshold value of ≤200 viral copies/mL. Results Analysis of VL trends showed a statistically significant improvement in VL suppression between 2002 to 2011, from 33.6% of clients achieving the 200 copies/mL threshold in 2002 to 70.3% in 2011 (P<0.001). Taking into account the proportion of clients alive and in care and on ART, the known diagnosed HIV population in Barbados, and estimates of unknown HIV infections, this translates into an estimated 26.2% VL suppression at a population level at the end of 2010. Conclusions We have demonstrated a significant trend towards optimal VL suppression in clients utilizing the services of the national HIV treatment program in Barbados over a 10-year period. Estimates of VL suppression at a population level are similar to reports in developed countries that applied similar methodologies and this could suggest a public health benefit of ART in minimizing the risk of sexual transmission of HIV. Continued efforts are warranted to extend HIV testing to hidden populations in Barbados and linking infected persons to care earlier in their disease.
Social networks, language learning and language school student sojourners : a qualitative study

This thesis investigates individual language school student sojourners’ learning experiences in the UK. It takes into account the importance of learners learning through interaction with others in the target language community and recognises how learners’ social networks affect their language learning and use. There are many studies about students who study abroad for academic purposes and immigrant learners, but not many relating to individual language learners in private language schools. In order to fill this gap, this study focused on individual language school learners. With the intention of understanding how the social networks and language learning interact over time as part of their sojourner experience, I utilised different theoretical frameworks that have been applied to other groups of language learners and concluded that these frameworks are also applicable to private language school students. I recognised that in order to understand my participants’ learning experiences I needed to interact with them and also observe how they interacted with their social world. Therefore, formal interviews (semi-structured) and informal interviews (informal group meeting or chat) were the main methods for my study together with observation of interaction in various situations. This study identified the expectations that learners had with regard to the target language community, host families and native speakers’ attitudes towards foreign students, and the realisation that these expectations were higher than what was actually encountered. It also identified the steps the individual language learners took to overcome these disappointments and how they reconstructed their relationships with the target language and community respectively. In contrast with many previous studies which only focused on learning from native speakers, my study recognised that learners sometimes can have more interpersonal contact with their fellow students than native speakers. And consequently they benefit more from these contacts, in terms of language learning, than from native speakers. This thesis also helps language learners and language educators recognise basic theoretical frameworks which could help them evaluate the benefits and problems related to learning through interpersonal contact. And with this understanding learners will be able to facilitate their autonomous learning in the target language community.
Towards Checking the Usefulness of Verification Tools

Building verification tools is what researchers in the field are good at, but evaluating if they are actually useful and useable is often a much harder problem. We propose a very simple idea to address this problem, namely, a framework in which we capture what a programmer does during a programming exercise and mechanisms to then allow us to incorporate verification (including testing) tools to analyze the resulting code snapshots. The ultimate idea is to build up a very diverse set of code benchmarks on which verification tools can be evaluated. However unlike current benchmarks that are somewhat cherry-picked for showing off certain tools’ strengths, this one will be based on actual code being captured during programming.
How neurogenesis finds its place in a hardwired sensory system

So far most studies on adult neurogenesis aimed to unravel mechanisms and molecules regulating the integration of newly generated neurons in the mature brain parenchyma. The exceedingly abundant amount of results that followed, rather than being beneficial in the perspective of brain repair, provided a clear evidence that adult neurogenesis constitutes a necessary feature to the correct functioning of the hosting brain regions. In particular, the rodent olfactory system represents a privileged model to study how neuronal plasticity and neurogenesis interact with sensory functions. Until recently, the vomeronasal system (VNS) has been commonly described as being specialized in the detection of innate chemosignals. Accordingly, its circuitry has been considered necessarily stable, if not hard-wired, in order to allow stereotyped behavioral responses. However, both first and second order projections of the rodent VNS continuously change their synaptic connectivity due to ongoing postnatal and adult neurogenesis. How the functional integrity of a neuronal circuit is maintained while newborn neurons are continuously added—or lost—is a fundamental question for both basic and applied neuroscience. The VNS is proposed as an alternative model to answer such question. Hereby the underlying motivations will be reviewed.
Air Pollution Exposure and Cardiovascular Disease

Ambient air pollution (AAP) and particulate matters (PM) have been closely associated with adverse health effects such as respiratory disease and cardiovascular diseases. Previous studies have examined the adverse health effects associated with short- and long-term exposure to AAP and outdoor PM on respiratory disease. However, the effect of PM size (PM_2.5 and PM_10) on cardiovascular disease has not been well studied. Thus, it remains unclear how the size of the inhalable particles (coarse, fine, or ultrafine) affects mortality and morbidity. Airborne PM concentrations are commonly used for ambient air quality management worldwide, owing to the known effects on cardiorespiratory health. In this article, we assess the relationship between cardiovascular diseases and PM, with a particular focus on PM size. We discuss the association of PM_2. 5 and PM_10, nitrogen dioxide (NO_2), and elemental carbon with mortality and morbidity due to cardiovascular diseases, stroke, and altered blood pressure, based on epidemiological studies. In addition, we provide evidence that the adverse health effects of AAP and PM are more pronounced among the elderly, children, and people with preexisting cardiovascular and respiratory conditions. Finally, we critically summarize the literature pertaining to cardiovascular diseases, including atherosclerosis and stroke, and introduce potential studies to better understand the health significance of AAP and PM on cardiovascular disease.
Long-term Effect of Sodium Oxybate (Xyrem®) in Spasmodic Dysphonia with Vocal Tremor

Background Symptoms of spasmodic dysphonia (SD) are usually managed successfully with botulinum toxin injections. Vocal tremor (VT), which accompanies SD, has a poor response to this treatment. Case Report We report a case of a female with SD and VT who became symptom-free for 10 months after the intake of a single dose of sodium oxybate (Xyrem®). The long-term treatment effect correlated with attenuated brain activity in the key regions of dystonic brain network. Discussion Our case demonstrates that the novel treatment of sodium oxybate may hold promise for SD patients, especially those who have associated VT.
Strategies for Problem Determination using Probing

As distributed systems continue to grow in size and complexity, scalable and cost-efficient techniques are needed for performing tasks such as problem determination and fault diagnosis. In this paper, we address these tasks using probes, or test transactions, which replace traditional “passive” event-correlation techniques with a more active, real-time information-gathering approach. We provide a theoretical foundation and a set of practical techniques for implementing efficient probing strategies the main issue is minimizing the cost of probing while maximizing the diagnostic accuracy of the probe set. We show that finding an optimal probe set is NP-hard and devise polynomial-time approximation algorithms that demonstrate excellent empirical performance, even on large networks. We also implement an active, on-line probing strategy that yields a significant reduction in the probe set size.
Spontaneous progression of ligatured induced peri-implantitis at implants with different surface characteristics. An experimental study in dogs II: histological observations.

AIM The aim of the present study was to analyze tissue reactions to plaque formation following ligature removal in experimental peri-implantitis at commercially available implants in dogs. MATERIAL AND METHODS Mandibular premolars and the three anterior premolars in both sides of the maxilla were extracted in six Labrador dogs. After 3 months, four implants representing four different implant systems--groups A (turned), B (TiOblast), C (SLA), D (TiUnite)--were placed in a randomized order in the right side of the mandible. Three months after implant installation, experimental peri-implantitis was initiated by placement of ligatures and plaque formation. The ligatures were removed when about 40-50% of the supporting bone was lost. After the subsequent 24-week period of continued plaque accumulation, block biopsies containing implants and their surrounding tissues were obtained and prepared for histological analysis. RESULTS All types of implants exhibited extensive inflammatory cell infiltrates and large associated crater-formed osseous defects. The lesions were consistently characterized by insufficient encapsulation of pus and biofilm layers and the inflammatory cell infiltrates extended apical of the pocket epithelium. The presence of numerous osteoclasts indicated active tissue destruction. The vertical dimension and the overall surface area of the infiltrated connective tissue (ICT) were larger at implants of group D than at other implant types. CONCLUSION It is suggested that spontaneous progression of peri-implantitis is associated with severe inflammation and tissue destruction.
On the genetic and environmental associations between body composition, depression symptoms and smoking behavior

Genome-wide association studies (GWAS) of body mass index (BMI) using large samples have yielded approximately a dozen robustly associated variants and implicated additional loci. Individually these variants have small effects and in aggregate explain a small proportion of the variance. As a result, replication attempts have limited power to achieve genome-wide significance, even with several thousand subjects. Since there is strong prior evidence for genetic influence on BMI for specific variants, alternative approaches to replication can be applied. Instead of testing individual loci sequentially, a genetic risk sum score (GRSS) summarizing the total number of risk alleles can be tested. In the current study, GRSS comprised of 56 top variants catalogued from two large metaanalyses was tested for association with BMI in the Molecular Genetics of Schizophrenia controls (2,653 European-Americans, 973 African-Americans). After accounting for covariates known to influence BMI (ancestry, sex, age), GRSS was highly associated with BMI (p-value = 3.19x10) although explained a limited amount of the variance (0.66%). However, area under receiver operator criteria curve (AUC) estimates indicated that the GRSS and covariates significantly predicted overweight and obesity classification with maximum discriminative ability for predicting class III obesity (AUC=0.697). The relative contributions of the individual loci to GRSS were examined post hoc and the results were not due to a few highly significant variants, but rather the result of numerous variants of small effect. This study provides evidence of the utility of a GRSS as an alternative approach to replication of common polygenic variation in complex traits.
Transcytosis of iota‐toxin across polarized CaCo‐2 cells

Iota‐toxin from Clostridium perfringens type E is a binary toxin consisting of two independent proteins, an enzymatic Ia and binding Ib component. Ia catalyses ADP‐ribosylation of actin monomers, thus disrupting the actin cytoskeleton. In this report, we show that Ia plus Ib applied apically or basolaterally induce a rapid decrease in the transepithelial resistance (TER) of CaCo‐2 cell monolayers and disorganization of actin filaments as well as the tight and adherens junctions. Ib alone, on the apical or basolateral side, slowly decreased the TER without affecting the actin cytoskeleton, possibly via pore formation. Interestingly, the two iota‐toxin components inoculated separately on each cell surface induced cytopathic effects and a TER decrease. Anti‐Ib sera, raised against the whole molecule or the Ia docking domain and applied to the opposite cell side versus Ib, neutralized the TER decrease. In addition, radioactive Ib incubated in the basolateral compartment was detected on the apical side by selective cell surface biotinylation. This argues for a transcytotic routing of Ib to mediate internalization of Ia from the opposite cell surface. Bafilomycin A1 also prevented the cytopathic effects of Ia and Ib applied separately to each cell side, possibly by blocking translocation of Ia into the cytosol and/or the intracellular transport of Ib. Ib is either routed into the cell independently of Ia, trans‐cytosed and permanently exposed on the opposite cell surface or continuously recycled between an endosomal compartment and the cell surface.
Occupy Wall Street in alternative and mainstream media : A comparative analysis of the social movement’s framing in the media

The thesis provides an analysis of the different ways the Occupy Wall Street was presented by OccupyWallSt.org ( the movement’s own media source), and The New York Times, The Wall Street Journal and USA Today from July 2011 up to the end of June 2012. This was done by using Entman’ theory of media framing together with Castells’ network theory of power. The former provided a way of addressing the different types of frames that mainstream media utilize, while the latter offered an understanding of how power is built through the media processes. Additionally, Castells’ theory described another type of media frame which is mostly used by alternative media, the counter frame, which could successfully be applied to study the content that the social movement decided to provide about itself.The study first employs a quantitative approach by using Crawdad, a centering resonance analysis (CRA) software. This provides a reliable pool of data that was then analyzed by using the above theories. Additionally, in order to check the reliability of the qualitative conclusions, a statistical test was done for the overall top centers resulting from the CRA.
The Interactive Effects of Intensity and Direction of Cognitive and Somatic Anxiety and Self-Confidence upon Performance

This study examines intensity and direction of competitive state anxiety symptoms, and the interactive influence of anxiety subcomponents upon netball performance. Netball players (N = 45) completed the modified Competitive State Anxiety Inventory-2 (CSAI-2) and a retrospective performance measure over a season, utilizing an intraindividual design. The modified CSAI-2 includes a direction scale assessing the facilitative or debilitative interpretation of the original intensity symptoms. Although the facilitative influence of anxiety upon performance did not emerge directly through the direction scale, a significant interaction emerged from the two-factor Cognitive Anxiety × Physiological Arousal quadrant analyses, suggesting that anxiety may enhance performance, as proposed by catastrophe model predictions. Findings also highlighted the importance of self-confidence for possible inclusion in higher order catastrophe models.
Robust control and modeling a 2-DOF Inertial Stabilized Platform

This paper presents an uncertain linear model for an Inertial Stabilization Platform (ISP). The system has a 2 degree of freedom (DOF) gimbal which will be attached to a moving vehicle and the optical sensors mounted on stabilized gimbal. The main purpose of an ISP is to eliminate the various disturbance and body motion to make the line of sight (LOS), hold steady in an inertial space. Due to dynamical model of the 2-DOF gimbal, friction, cable restraint, noise, other disturbances from the outside environment and the motions of the vehicle's body (as a result of maneuvering or vibration), the pointing and tracking accuracy of the gimbaled system may strongly degrade. These disturbances are typically nonlinear. Modeling and controlling the stabilization loop with these nonlinearities are the main problem. The approach of this paper is considering a linear doubted model. Linearity makes the model simple and so linear classic controller can be used to meeting design requirements. Therefore the cost of the design and implementation stages will decrease. In addition uncertainty makes the model practical and so the nonlinear nature of mentioned disturbance can be interpreted by this model. So this built ISP by a PI controller which is capable enough to overcome the disturbances and to meet the implication requirements will be controlled. For decreasing the effect of these uncertainties and other probable variation in ISP's parameters on system performance, a determined simple structure for robust enhancer compensator is used and designed.
On the Problem of Local Minima in Backpropagation

The authors propose a theoretical framework for backpropagation (BP) in order to identify some of its limitations as a general learning procedure and the reasons for its success in several experiments on pattern recognition. The first important conclusion is that examples can be found in which BP gets stuck in local minima. A simple example in which BP can get stuck during gradient descent without having learned the entire training set is presented. This example guarantees the existence of a solution with null cost. Some conditions on the network architecture and the learning environment that ensure the convergence of the BP algorithm are proposed. It is proven in particular that the convergence holds if the classes are linearly separable. In this case, the experience gained in several experiments shows that multilayered neural networks (MLNs) exceed perceptrons in generalization to new examples. >
Impact of Time-of-Flight on PET Tumor Detection

Time-of-flight (TOF) PET uses very fast detectors to improve localization of events along coincidence lines-of-response. This information is then utilized to improve the tomographic reconstruction. This work evaluates the effect of TOF upon an observer's performance for detecting and localizing focal warm lesions in noisy PET images. Methods: An advanced anthropomorphic lesion-detection phantom was scanned 12 times over 3 days on a prototype TOF PET/CT scanner (Siemens Medical Solutions). The phantom was devised to mimic whole-body oncologic 18F-FDG PET imaging, and a number of spheric lesions (diameters 6–16 mm) were distributed throughout the phantom. The data were reconstructed with the baseline line-of-response ordered-subsets expectation-maximization algorithm, with the baseline algorithm plus point spread function model (PSF), baseline plus TOF, and with both PSF+TOF. The lesion-detection performance of each reconstruction was compared and ranked using localization receiver operating characteristics (LROC) analysis with both human and numeric observers. The phantom results were then subjectively compared to 2 illustrative patient scans reconstructed with PSF and with PSF+TOF. Results: Inclusion of TOF information provides a significant improvement in the area under the LROC curve compared to the baseline algorithm without TOF data (P = 0.002), providing a degree of improvement similar to that obtained with the PSF model. Use of both PSF+TOF together provided a cumulative benefit in lesion-detection performance, significantly outperforming either PSF or TOF alone (P < 0.002). Example patient images reflected the same image characteristics that gave rise to improved performance in the phantom data. Conclusion: Time-of-flight PET provides a significant improvement in observer performance for detecting focal warm lesions in a noisy background. These improvements in image quality can be expected to improve performance for the clinical tasks of detecting lesions and staging disease. Further study in a large clinical population is warranted to assess the benefit of TOF for various patient sizes and count levels, and to demonstrate effective performance in the clinical environment.
Mathematical modeling of postmenopausal osteoporosis and its treatment by the anti-catabolic drug denosumab

Denosumab, a fully human monoclonal antibody, has been approved for the treatment of postmenopausal osteoporosis. The therapeutic effect of denosumab rests on its ability to inhibit osteoclast differentiation. Here, we present a computational approach on the basis of coupling a pharmacokinetics model of denosumab with a pharmacodynamics model for quantifying the effect of denosumab on bone remodeling. The pharmacodynamics model comprises an integrated systems biology‐continuum micromechanics approach, including a bone cell population model, considering the governing biochemical factors of bone remodeling (including the action of denosumab), and a multiscale micromechanics‐based bone mechanics model, for implementing the mechanobiology of bone remodeling in our model. Numerical studies of postmenopausal osteoporosis show that denosumab suppresses osteoclast differentiation, thus strongly curtailing bone resorption. Simulation results also suggest that denosumab may trigger a short‐term bone volume gain, which is, however, followed by constant or decreasing bone volume. This evolution is accompanied by a dramatic decrease of the bone turnover rate by more than one order of magnitude. The latter proposes dominant occurrence of secondary mineralization (which is not anymore impeded through cellular activity), leading to higher mineral concentration per bone volume. This explains the overall higher bone mineral density observed in denosumab‐related clinical studies. Copyright © 2013 John Wiley & Sons, Ltd.