Miracle-dz/UniFAR-FTUs huggingface dataset:
Contrast enhanced ultrasound in atherosclerotic carotid artery disease.

AIM The traditional morphological parameters for the description of a carotid atherosclerotic plaque (degree of stenosis, echogenicity, systolic peak velocity etc.) are insufficient for the prediction of the risk of embolization. Contrast enhanced ultrasound (CEUS), based on the theory of inflammation and neoangiogenesis, seems to have a great potential for the detection of unstable plaques. The purpose of our work was to compare echogenicity of the plaque (evaluated with the Grey Scale Median; GSM), the degree of stenosis and CEUS with the histopathological findings. METHODS Patients with indication for internal carotid endarterectomy (CEA) underwent a preoperative imaging study with B-mode echo Doppler Ultrasound and with CEUS. The contrast enhancement of the plaque was described with two parameters: the maximum and mean signal intensity (SImax, SImean). After the surgical operation the removed plaque is sent to the pathology laboratory for the measurement of the neoangiogenesis (vessel density, VD). RESULTS Fifty-one consecutive patients were enrolled (12 symptomatic, 39 asymptomatic). Analysis pointed out significant differences between symptomatic and asymptomatic patients for: GSM median 14 (I quartile 11.5; III quartile 23) versus 32.5 (27-42.25) (P=0.012); SI (%) SImax 30 (29-35.5) versus 24 (19.7-27) (P<0.001) and SImean 23 (20.5-27) versus 15 (8-18.25) (P<0.001); VD (vessels/mm2) 41.5 (30-70) versus 12.6 (7-18.6) (P<0.001), respectively. Moreover, a cut-off value was determined between the two groups for each parameter: GSM:25, SImax:28%, SImean:20%, and VD: 25/mm2. Combined analysis showed that plaques with greater contrast enhancement had more newly formed capillaries and that plaques with lower GSM values correlated with greater vascularization. CONCLUSION The study confirms that in vitro neoangiogenesis, contrast enhancement and stability of the plaque are strongly connected and CEUS appears to be one of the most promising tools for the stratification of the carotid plaque vulnerability.
Constraints, lazy constraints, or propagators in ASP solving: An empirical analysis*

Abstract Answer set programming (ASP) is a well-established declarative paradigm. One of the successes of ASP is the availability of efficient systems. State-of-the-art systems are based on the ground+solve approach. In some applications, this approach is infeasible because the grounding of one or a few constraints is expensive. In this paper, we systematically compare alternative strategies to avoid the instantiation of problematic constraints, which are based on custom extensions of the solver. Results on real and synthetic benchmarks highlight some strengths and weaknesses of the different strategies.
Morpho-physiological analysis of tolerance to aluminum toxicity in rice varieties of North East India

Aluminum (Al) is the third most abundant metal in earth crust, whose chemical form is mainly dependent on soil pH. The most toxic form of Al with respect to plants is Al3+, which exists in soil pH <5. Acidic soil significantly limits crop production mainly due to Al3+ toxicity worldwide, impacting approximately 50% of the world’s arable land (in North-Eastern India 80% soil are acidic). Al3+ toxicity in plants ensues root growth inhibition leading to less nutrient and water uptake impacting crop productivity as a whole. Rice is one of the chief grains which constitutes the staple food of two-third of the world population including India and is not untouched by Al3+ toxicity. Al contamination is a critical constraint to plant production in agricultural soils of North East India. 24 indigenous Indica rice varieties (including Badshahbhog as tolerant check and Mashuri as sensitive check) were screened for Al stress tolerance in hydroponic plant growth system. Results show marked difference in growth parameters (relative growth rate, Root tolerance index, fresh and dry weight of root) of rice seedlings due to Al (100 μM) toxicity. Al3+ uptake and lipid peroxidation level also increased concomitantly under Al treatment. Histochemical assay were also performed to elucidate uptake of aluminum, loss of membrane integrity and lipid peroxidation, which were found to be more in sensitive genotypes at higher Al concentration. This study revealed that aluminum toxicity is a serious harmful problem for rice crop productivity in acid soil. Based on various parameters studied it’s concluded that Disang is a comparatively tolerant variety whereas Joymati a sensitive variety. Western blot hybridization further strengthened the claim, as it demonstrated more accumulation of Glutathione reductase (GR) protein in Disang rice variety than Joymati under stressed condition. This study also observed that the emergence of lethal toxic symptoms occurs only after 48h irrespective of the dose used in the study.
Lower levels of insulin‐like growth factor‐1 standard deviation score are associated with histological severity of non‐alcoholic fatty liver disease

Growth hormone (GH) deficiency may be associated with histological progression of non‐alcoholic fatty liver disease (NAFLD) which includes non‐alcoholic fatty liver (NAFL) and non‐alcoholic steatohepatitis (NASH). Insulin‐like growth factor 1 (IGF‐1) is mainly produced by hepatocytes and its secretion is stimulated by GH. Our aim was to determine whether more histologically advanced NAFLD is associated with low circulating levels of IGF‐1 in Japanese patients.
Precipitation Climatology over Mediterranean Basin from Ten Years of TRMM Measurements

Abstract. Climatological features of mesoscale rain activities over the Mediterranean region between 5° W–40° E and 28° N–48° N are examined using the Tropical Rainfall Measuring Mission (TRMM) 3B42 and 2A25 rain products. The 3B42 rainrates at 3-hourly, 0.25°×0.25° spatial resolution for the last 10 years (January 1998 to July 2007) are used to form and analyze the 5-day mean and monthly mean climatology of rainfall. Results show considerable regional and seasonal differences of rainfall over the Mediterranean Region. The maximum rainfall (3–5 mm day−1) occurs over the mountain regions of Europe, while the minimum rainfall is observed over North Africa (~0.5 mm day−1). The main rainy season over the Mediterranean Sea extends from October to March, with maximum rainfall occurring during November–December. Over the Mediterranean Sea, an average rainrate of ~1–2 mm day−1 is observed, but during the rainy season there is 20% larger rainfall over the western Mediterranean Sea than that over the eastern Mediterranean Sea. During the rainy season, mesoscale rain systems generally propagate from west to east and from north to south over the Mediterranean region, likely to be associated with Mediterranean cyclonic disturbances resulting from interactions among large-scale circulation, orography, and land-sea temperature contrast.
Self-reported depression and anxiety after prenatal famine exposure: mediation by cardio-metabolic pathology?

Evidence from previous studies suggests an association between prenatal exposure to famine and increased risk for depression. The aim of this study was to investigate whether prenatal exposure to the Dutch famine is associated with self-reported depression/anxiety and whether a potential association is mediated by the presence of cardio-metabolic disease. A total of 819 persons, born as term singletons around the 1944–1945 Dutch famine, filled out the Hospital Anxiety and Depression Scale (HADS) and were asked about their medical history. As indicators of cardio-metabolic disease we included type 2 diabetes (T2D), hypertension and coronary heart disease (CHD). In the total study population, exposure to famine during early gestation was associated with the presence of self-reported mild-to-severe anxiety. Evidence was found for several interactions between exposure in early gestation and sex. Subsequent analyses according to sex showed that men exposed to famine during early gestation scored higher on the HADS depression scale. Self-reported mild-to-severe anxiety symptoms were more prevalent among early exposed men. No such differences were found in women. T2D and hypertension were not correlated with any of the depression and anxiety measures. Adjusting for the presence of CHD did minimally attenuate the size of the reported associations. In conclusion, the present results do not match those previously reported in prenatally famine-exposed individuals. We found only weak evidence for an association between prenatal famine exposure and symptoms of depression and anxiety, which was shown exclusively in men exposed during early gestation.
Two sequential randomized trials of community participation to recruit women for mammographic screening.

BACKGROUND If mammographic screening is to reduce mortality from breast cancer, it is essential that a high proportion of the target population attend for screening. In order to achieve this, effective recruitment strategies are needed. This paper reports two trials of recruitment strategies for mammographic screening involving eight communities in rural New South Wales (NSW), Australia. METHODS Each trial involved two matched pairs of towns in the Hunter Valley region of NSW. Towns were randomly allocated to intervention, receiving either mass media promotion or community participation in Trial 1 and community participation or family physician involvement in Trial 2. RESULTS In Trial 1, significantly higher attendance rates were observed in the two towns that received the community participation intervention compared with their matched media promotion towns (63% vs 34%, P < 0.001 and 51% vs 34%, P < 0.01). In Trial 2, a significantly higher attendance rate was observed in one town that received the family physician involvement intervention compared with its matched town which received the community participation intervention (68% vs 51%, P < 0.01). There was no significant difference in attendance in the other pair of towns (68% vs 58%, P = 0.11). CONCLUSIONS Both community participation and family practitioner involvement are more promising strategies for the promotion of attendance at mammographic screening facilities than media promotion alone.
Mindsets of Leadership Education Undergraduates: An Approach to Program Assessment

Students ( N = 313) in undergraduate leadership degree programs at Texas A&M University were surveyed to determine their leadership mindset using hierarchical and systemic thinking preferences. Significant differences in thinking were found between gender and academic classification. Male leadership students scored greater in hierarchical thinking than females. Seniors, leadership students typically in their last semester of studies, scored significantly lower in hierarchical thinking than juniors. Findings indicate formal leadership coursework influences students’ leadership mindsets.
Using Deception to Enhance Security: A Taxonomy, Model, and Novel Uses

Almeshekah, Mohammed H. PhD, Purdue University, August 2015. Using Deception to Enhance Security: A Taxonomy, Model, and Novel Uses. Major Professors: Eugene H. Spa↵ord and Mikhail J. Atallah. As the convergence between our physical and digital worlds continue at a rapid pace, securing our digital information is vital to our prosperity. Most current typical computer systems are unwittingly helpful to attackers through their predictable responses. In everyday security, deception plays a prominent role in our lives and digital security is no di↵erent. The use of deception has been a cornerstone technique in many successful computer breaches. Phishing, social engineering, and drive-bydownloads are some prime examples. The work in this dissertation is structured to enhance the security of computer systems by using means of deception and deceit. Deception-based security mechanisms focus on altering adversaries’ perception of computer systems in a way that can confuse them and waste their time and resources. These techniques exploit adversaries’ biases and present them with a plausible alternative to the truth bringing a number of unique advantages to computer security. In addition, deception has been widely used in many areas of computing for decades and security is no di↵erent. However, deception has only been used haphazardly in computer security. In this dissertation we present a framework where deception can be planned and integrated into computer defenses. We posit how the well-known Kerckho↵s’s principle has been misinterpreted to drive the security community away from deception-based mechanisms. We present two schemes that employ deception to protect users’ passwords during transmission and at rest when they are stored on a computer server. Moreover, we designed and built a centralized deceptive server that can be hooked to
Simulated Power of the Discrete Cramer-von Mises Goodness-of-Fit Tests

The use of goodness-of-fit test statistics for discrete or categorical data is widespread throughout the research community with the ChiSquare the most popular when a researcher aims to determine if observed categorical data differs from a hypothesized multinomial distribution. Even for ordinal categorical data, the use of empirical distribution function (EDF) test statistics such as the Kolmogorov-Smirnov, the three Cramer-von Mises (A2 , W2 and U2 as defined below) and various modifications of these are limited in the literature. Power studies of the EDF type test statistics are even more limited. This paper compares the simulated power of the three Cramer-von Mises test statistics with that of the Chi-Square test statistic for a uniform null hypothesis against a variety of alternative distributions which are summarized in Figure 1. Recommendations are made on which is the most powerful test statistic for the predefined alternative distributions. The results of the simulated power studies in this paper lead to the following general recommendations: • For trend type alternatives A2 and W2 appear much more powerful than U2 and χ2. (See Figure 2 for a uniform null against a decreasing trend alternative distribution). • For all the other investigated alternative distributions U2 and χ2 appear much more powerful than A2 and W2. (See Figure 3 for a uniform null against a leptokurtic type alternative distribution).
First description of the karyotype of a eucharitid wasp (Hymenoptera, Chalcidoidea, Eucharitidae)

Abstract The haploid karyotype of Kapala sp. (Eucharitidae), a parasite of the Neotropical ant Dinoponera lucida Emery, 1901 (Hymenoptera, Formicidae), is reported for the first time. It consists of four metacentric chromosomes. Chromosomes in the family Eucharitidae were unknown so far; therefore, our results confirm that multiple parallel chromosomal fusions have taken place in several lineages within the superfamily Chalcidoidea.
Right-Wing Authoritarianism, Social Dominance Orientation, and Attachment: An Italian Study

The paper presents the results of a theoretical and empirical study of the relations between right-wing authoritarianism (RWA), social dominance orientation (SDO), and attachment. A study on 353 Italian university students in Turin was conducted. A correlation between RWA and SDO was found, and a structural equation model of the origins of RWA and SDO was built using attachment style as a principal predictor of the two constructs. Several psychosocial variables (course of studies undertaken, group participation, and importance of religion) were also used as predictors. The major results were: (a) RWA and SDO correlate positively, but not very strongly; (b) attachment styles directly and/or indirectly influence RWA and SDO; and (c) RWA and SDO each have specific predictors, but also share one predictor, importance of religion, which raises RWA scores, but lowers SDO scores. The limits and future developments of this research are discussed.
Autonomic Nervous System Differences among Emotions

Following decades of controversy and uncertainty, there is now sufficient empirical basis for asserting the existence of a limited set of autonomic differences among emotions. Findings of autonomic distinctions among emotions-derived from the work of the author and his colleagues using two methods of emotion elicitation are reviewed. For five of these autonomic distinctions, convergent findings from the work of other investigators using the same and other elicitation methods are presented.
Combining Model-Based Testing and Runtime Monitoring for Program Testing in the Presence of Nondeterminism

In case of underspecified or not fully predictable systems, models specifying system behaviors are nondeterministic. Nondeterminism poses several challenges for the validation and verification activities, including the problem of inconclusive tests in model-based testing with model checker. It is a validation technique that uses model checker counterexamples as test cases. In this paper, we tackle the problem of testing nondeterministic systems by combining model-based testing and runtime conformance monitoring: the input sequences of the tests are automatically generated from nondeterministic models; then their execution is runtime monitored to check conformance of the code w.r. t. its specification. This technique provides an oracle for the test data, it never bears inconclusive responses, and it allows measuring the requirement coverage. The approach uses the Abstract State Machines as formal method for specification purposes and Java as implementation language. As a proof of concepts, the Tic-Tac-Toe game is taken as example of a system with nondeterministic behavior (both at specification and code levels).
Information Behavior and Information Practice: Reviewing the “Umbrella Concepts” of Information‐Seeking Studies1

Information behavior and information practice, two major concepts denoting the general ways in which people deal with information, are analyzed. Because of their general nature, they may be conceived of as umbrella concepts drawing on “umbrella discourses” with similar names. Information behavior is currently the dominating umbrella concept, while information practice stands as a critical alternative. The discourses above appear to be quite fragmentary, and researchers on information seeking rarely reflect on the discursive nature of the umbrella concepts. The discourse on information behavior primarily draws on the cognitive viewpoint, while information practice is mainly inspired by the ideas of social constructionism. The comparative study of the above concepts and discourses serves the needs to generate a self‐reflective attitude to familiar discursive formations, in particular among researchers of information seeking.
Middle-Grade Predictors of Students’ Motivation and Behavior in High School

This study investigated students’ school context, motivation, and behavior across the transition to high school. During the final marking period of 7th and 9th grades, students completed questionnaires assessing their academic self-concept and perceptions of the motivational context created by teachers, peers, and their economic opportunity structure. Achievement and discipline data were also collected at both time points. Ninth graders provided data on their motivation (effort and valuing of education) and future academic plans. Students reported more positive motivational contexts in 9th grade versus 7th grade, particularly with respect to teachers. Seventh-grade contextual variables were associated with 9th-grade motivation and adjustment. Discriminant function analyses found that 7th-grade variables discriminated between least adjusted and better adjusted high school students. Students’7th-grade discipline referrals, doubts about the economic value of education, and negative expectations of peers and teachers were the best discriminators between less and more adjusted 9th graders.
Renal interstitial fibrosis induced by high-dose mesoporous silica nanoparticles via the NF-κB signaling pathway

Previous studies have indicated that the nephrotoxicity induced by mesoporous silica nanoparticles (MSNs) is closely related to inflammation. Nuclear factor kappa B (NF-κB), a common rapid transcription factor associated with inflammation, plays an important role in the process of many kidney diseases. Acute toxicity assessment with a high-dose exposure is critical for the development of nanoparticle, as a part of standardized procedures for the evaluation of their toxicity. The present study was undertaken to observe the acute toxicity, predict the potential target organs of MSNs injury, and test the hypothesis that the NF-κB pathway plays a role in mediating the acute kidney injury and renal interstitial fibrosis in mice induced by MSNs. Balb/c mice were intraperitoneally injected with MSNs at concentrations of 150, 300, or 600 mg/kg. All of the animals were euthanized 2 and 12 days after exposure, and the blood and kidney tissues were collected for further studies. In vitro, the cytotoxicity, fibrosis markers, and NF-κB pathway were measured in a normal rat kidney cell line (NRK-52E). Acute kidney injury was induced by MSNs in mice after 2 days, some renal tubules regenerated and renal interstitial fibrosis was also observed. The expression of fibrosis markers and the nuclear translocation of NF-κB p65 in the kidney homogenates increased after exposure to MSNs. The in vitro study showed that MSNs cause cytotoxicity in NRK-52E cells and increased the expression of fibrosis markers. In addition, the NF-κB pathway could be induced, and inhibition of the NF-κB pathway could alleviate the fibrosis caused by MSNs. We conclude that inflammation is a major effector of the acute kidney toxicity induced by MSNs and results in renal interstitial fibrosis, which is mediated by the NF-κB signaling pathway.