Miracle-dz/UniFAR-FTUs huggingface dataset:
Edinburgh Research Explorer Analysis of the early immune response to infection by Infectious Bursal Disease Virus (IBDV) in chickens differing in their resistance to the disease

Chicken whole-genome gene expression arrays were used to analyze the host response to infection by infectious bursal disease virus (IBDV). Spleen and bursal tissue were examined from control and infected birds at 2, 3, and 4 days postinfection from two lines that differ in their resistance to IBDV infection. The host response was evaluated over this period, and differences between susceptible and resistant chicken lines were examined. Antiviral genes, including IFNA , IFNG , MX1 , IFITM1 , IFITM3 and IFITM5 , were upregulated in response to infection. Evaluation of this gene expression data allowed us to predict several genes as candidates for involvement in resistance to IBDV. the differences in the between that differ and predict genes.
Lower Urinary Tract Symptoms, Depression, Anxiety and Systemic Inflammatory Factors in Men: A Population-Based Cohort Study

Background The relationship between lower urinary tract symptoms (LUTS) and common mental health disorders such as depression and anxiety in men remains unclear. Inflammation has recently been identified as an independent risk factor for LUTS and depression. This study aimed to assess the association between depression, anxiety and LUTS, and the moderating influence of systemic inflammation, in the presence of other biopsychosocial confounders. Methods Participants were randomly-selected from urban, community-dwelling males aged 35–80 years at recruitment (n = 1195; sample response rate:67.8%). Of these, 730 men who attended baseline (2002–5) and follow-up clinic visits (2007–10), with complete outcome measures, and without prostate or bladder cancer and/or surgery, neurodegenerative conditions, or antipsychotic medications use, were selected for the present study. Unadjusted and multi-adjusted regression models of incident storage and voiding LUTS and incident depression and anxiety were combined with serum inflammatory markers (high-sensitive C-reactive protein (hsCRP), tumor necrosis factor-alpha (TNF-α), interleukin–6 (IL–6), myeloperoxidase (MPO), soluble e-selectin (e-Sel)) and socio-demographic, lifestyle, and health-related factors. Hierarchical multiple regression was used to assessed the moderating effect of inflammatory markers. Results The incidence of storage, voiding LUTS, depression and anxiety was 16.3% (n = 108), 12.1% (n = 88), 14.5% (n = 108), and 12.2% (n = 107). Regression models demonstrated that men with depression and anxiety at baseline were more likely to have incident storage, but not voiding LUTS (OR: 1.26, 99%CI: 1.01–4.02; and OR:1.74; 99%CI:1.05–2.21, respectively). Men with anxiety and storage LUTS at baseline were more likely to have incident depression (OR: 2.77, 99%CI: 1.65–7.89; and OR:1.45; 99%CI:1.05–2.36, respectively), while men with depression and voiding LUTS were more likely to have anxiety at follow-up (OR: 5.06, 99%CI: 2.81–9.11; and OR:2.40; 99%CI:1.16–4.98, respectively). CRP, TNF-α, and e-Sel were found to have significant moderating effects on the development of storage LUTS (1.06, 0.91–1.96, R2 change: 12.7%), depression (1.17, 1.01–1.54, R2 change: 9.8%), and anxiety (1.35, 1.03–1.76, R2 change: 10.6%), respectively. Conclusions There is a bidirectional relationship between storage, but not voiding, LUTS and both depression and anxiety. We observed variable moderation effects for selected inflammatory markers on the development of depression, anxiety and storage LUTS.
Exploring Conflict Resolution Styles: A Study of Turkish and American University Business Students

Examines the differences between the actions that Turkish and American students would take when they were confronted with conflict. Students received two cases describing an organizational setting. They were asked to place themselves in the situation of a member in conflict with a peer in the work environment. Cases were content‐analysed by the researchers. Indicates that the nature of the conflict situation is important in examining conflict resolution styles across cultures.
Effects of Stress Caused by the Public Personnel Selection Examination on the Performance of Physical Education and Other Teacher Trainees in Turkey

In this study I used the scanning method to detect the effects of stress resulting from the Public Personnel Selection Examination on teacher trainees studying at state universities in Turkey. Data were gathered using the Scale of Effect of Stress on Performance (Pehlivan, 1993) and it was found that the examination had negative impacts on students’ performance and that their stress levels were high. No significant relationship was found between the effect of stress on performance and gender, but there was a significant relationship between the impact of stress on performance and age, educational institution, and participants’ self-confidence in their ability to obtain a teaching position in state schools.
Ventilation and thoracoabdominal asynchrony during halothane anesthesia in infants.

To evaluate the ventilatory consequences of high chest wall compliance during anesthesia in infants, we assessed the effects of halothane at different fractions of minimal alveolar concentration (0.75, 1.0, and 1.5 MAC) on ventilation and movements of the rib cage and abdomen in infants < or = 12 mo of age (group I) and children (group II) > or = 12 mo of age. Minute ventilation decreased in group I, (20.6%, 0.75 to 1.5 MAC), but the change in group II did not reach the level of statistical significance. Tidal volume decreased with halothane level between 0.75 and 1.5 MAC, and its fall was greater in group I (32.7 +/- 11.2 vs. 22.6 +/- 9.3% in group II, P < 0.05). Duty cycle, or ratio of inspiratory to total time (TI/TT), increased in group II with halothane level but did not change in group I, resulting in a decreased TI in group I at higher halothane levels. Thoracic paradox increased with halothane level in group I but not group II. The increase in thoracic paradox in association with the fall in tidal volume between 0.75 and 1.5 MAC was greater in group I than group II (P < 0.05). We conclude that smaller infants depend more on inspiratory intercostal muscle activity to stabilize the thorax, leading to a greater degree of depression of ventilation during halothane depression of inspiratory intercostal activity.
The politics of ‘wrongful life’ itself: discursive (mal)practices and Tay-Sachs disease

Abstract This article examines eight wrongful life/wrongful birth suits filed by parents of children born with Tay-Sachs disease. Their legal claims are analysed in terms of the biopolitics of genetic risk that has emerged in recent decades with a view to arguing that, as health and disease are increasingly understood within a genetics framework, the individual is becoming responsibilized to be proactive and undergo genetic testing. At the same time, this responsibilization is being defined as a kind of entitlement rooted in historically specific ideas about personhood and quality of life. The only option for reconciling this contradiction has been simply to define responsibilization as the individual's right, thereby calling into question the notion of agency in genetic decision-making and revealing that choice in this context is in fact becoming the unfreedom to choose.
State of the art prediction of HIV-1 protease cleavage sites

MOTIVATION Understanding the substrate specificity of human immunodeficiency virus (HIV)-1 protease is important when designing effective HIV-1 protease inhibitors. Furthermore, characterizing and predicting the cleavage profile of HIV-1 protease is essential to generate and test hypotheses of how HIV-1 affects proteins of the human host. Currently available tools for predicting cleavage by HIV-1 protease can be improved. RESULTS The linear support vector machine with orthogonal encoding is shown to be the best predictor for HIV-1 protease cleavage. It is considerably better than current publicly available predictor services. It is also found that schemes using physicochemical properties do not improve over the standard orthogonal encoding scheme. Some issues with the currently available data are discussed. AVAILABILITY AND IMPLEMENTATION The datasets used, which are the most important part, are available at the UCI Machine Learning Repository. The tools used are all standard and easily available. CONTACT thorsteinn.rognvaldsson@hh.se.
Metadiscourse and discourse processes: Interactions and issues

This paper reports the impact of metadiscourse, a rhetorical domain that regulates the communicative function of language, on sixth‐grade students’ learning and attitudes. Metadiscourse directing the reader how to regard the author and the text was divided into two types, informational and attitudinal, and inserted in a social studies textbook chapter in either interpersonal or impersonal voice. Students were placed in high‐vocabulary or low‐vocabulary groups on the basis of test scores; in low‐comfort or high‐comfort groups on the basis of comfort index scores. The significant interaction results showed differential effects of metadiscourse on students’ learning. Low‐comfort students learned more when informational metadiscourse was presented in interpersonal voice, but high‐comfort ones learned less. The results for attitudinal metadiscourse were the opposite. The effect on attitudes was that students who read just one type of metadiscourse were more tolerant of opinions than those who read both types o.
MS-325: albumin-targeted contrast agent for MR angiography.

PURPOSE To evaluate the protein-binding and signal enhancement characteristics of MS-325, a gadolinium-based magnetic resonance (MR) imaging blood pool agent that binds to albumin, and compare results with those obtained with existing gadolinium- and iron oxide-based agents. MATERIALS AND METHODS Protein binding in human plasma was measured by means of ultrafiltration. T1 relaxation times (20 MHz) were measured in human plasma or ex vivo samples from rabbits and monkeys injected with 0.1 mmol of MS-325 per kilogram of body weight. Imaging (three-dimensional fast imaging with steady-state precession, or FISP) was performed at 1.0 T in phantoms, which contained varying concentrations of different agents, or rabbits after injection of 0.015-0.100 mmol/kg MS-325. RESULTS MS-325 is 80%-96% bound in human plasma and exhibits a relaxivity approximately six to 10 times that of gadolinium diethylenetriaminepentaacetic acid (DTPA). Images of phantoms containing MS-325 were significantly brighter than those containing existing gadolinium chelates or iron particles (monocrystalline iron oxide nanoparticle, or MION) at equivalent concentrations. Findings of in vivo studies indicated strong, persistent plasma T1 reduction with MS-325 for 1 hour (T1 of MS-325, 50-100 msec; T1 of Gd-DTPA, 200-400 msec) and strong vascular enhancement on MR images. CONCLUSION MS-325 is highly protein bound after injection and provides vascular signal enhancement superior to that provided with other agents. As the first gadolinium-based blood pool agent in human trials, MS-325 has the potential to enhance both dynamic and steady-state MR angiograms.
The Incremental Validity of Positive Emotions in Predicting School Functioning

Proponents of positive psychology have argued for more comprehensive assessments incorporating positive measures (e.g., student strengths) as well as negative measures (e.g., psychological symptoms). However, few variable-centered studies have addressed the incremental validity of positive assessment data. The authors investigated the incremental validity of positive emotions relative to negative emotions in predicting adolescents’ adaptive school functioning. Positive emotions demonstrated significant incremental validity in predicting school satisfaction, adaptive coping, and student engagement, but not self-reported GPA. The findings offer some support for the utility of positive measures in psychoeducational assessments.
Array CGH as a potential predictor of radiocurability in intermediate risk prostate cancer

Abstract Prostate cancer is the most common male cancer and up to one fifth of diagnosed patients will die of their disease. Current prognostic variables including T-category (of the TNM staging), the absolute or kinetics of prostatic specific antigen (PSA) and the pathologic Gleason score (GS) are utilized to place men in low, intermediate and high-risk prostate cancer risk groupings. There is great heterogeneity within the non-indolent intermediate risk group with respect to clinical response. It is therefore imperative that further genetic and other prognostic factors be identified to better individualize treatment. Somatic alterations in prostate cancer. Herein, we review the potential for somatic alterations in tumor-associated genes (based on comparative genomic hybridization (CGH) in prostate cancers to be novel prognostic, and possibly predictive, factors for prostate cancer radiotherapy response. Intermediate risk prostate cancers show alterations in a number of genes thought to be involved in radiosensitivity, DNA repair, cell death and stem cell renewal. These include deletions at 21q (TMPRSS2: ERG), 13q (RB1), 10q (PTEN), 8p (NKX3.1), additions at 8q21 (containing c-Myc)) and haplo-insufficiency for p53, PARP1, ATM and DNA-PKcs. Conclusions. The use of high-resolution CGH for fine-mapping of deletions and amplifications in pre-radiotherapy prostate cancer biopsies is feasible. Genetic alterations may delineate localized prostate cancer from systemic disease and be used as a predictive factor in that patients would be individually triaged to local (surgery versus radiotherapy) and/or adjuvant (adjuvant androgen ablation or post-operative radiotherapy) therapies in a prospective fashion to improve outcome. The knowledge of abnormal DNA repair pathways within in a given patient could allow for the judicious use of targeted agents (PARP/ATM inhibitors) as personalized medicine.
Public Opinion and Policy Initiatives for Online Privacy Protection

The ability to monitor and record Internet users' personal information has raised fears about online privacy. Consequently, consumers have put pressure on the federal government and the online industry to respond appropriately to their privacy concerns. This study uses Edelma''s theory of symbolic politics to assess the congruence between public concern about online privacy and recent legislative and industry efforts to address this concern.
Developing a Meaningful Identity for People with Disabilities through Serious Leisure Activities

Abstract Like other marginal groups, people with disabilities are generally reliant on government support resulting in a lifetime of dependency because they may never work in open employment. One alternative to paid employment is participation in serious leisure experiences (Stebbins, 1992). Serious leisure pursuits are engaged in by a small segment of people in society who are defined as amateurs, hobbyists or career volunteers. Patterson (1997) challenged the assumption that for many people with disabilities, paid employment in the workforce was the only viable option, and he suggested that serious leisure activities can provide similar benefits. For many people with disabilities who have large amounts of free time at their disposal, serious leisure is a work-like activity in the sense that it is challenging, contains a status system, and generates a set of colleagues. Stebbins (1998) further stated that leisure education should focus more on serious leisure activities for people with disabilities, and that counselling sessions should consist mainly of imparting knowledge about its nature, costs and rewards, as well as helping people with disabilities participate in specific serious leisure activities. This paper used a case study approach to select and interview three people with disabilities who are successfully participating in serious leisure activities. As a result, this has given them a sense of purpose to their lives as well as providing them with a positive alternative to paid employment, or given them practice in work skills in a non-threatening environment. The paper suggests that community based agencies involved with people with disabilities seriously consider the implementation of leisure education and counselling services, and the employment of trained leisure counsellors to support people with disabilities in their participation in serious leisure activities.
QSAR Models for P-Glycoprotein Transport Based on a Highly Consistent Data Set

P-Glycoprotein (Pgp) is involved in the elimination and in the disposition of a significant portion of marketed drugs. So far, publicly available data sets used for modeling Pgp transport included compounds tested in different assays, different cell lines, and different protocols. In this work, we present a collection of 478 Efflux Ratios (ERs) in MDCK-MDR1 cell lines, and from this collection we define a data set of 187 compounds that were tested in the Borst-derived MDCK-MDR1 cell lines. Of the 23 models resulting from the use of different descriptors, classification algorithms, and variable selection techniques, the 4 most accurate in external validation (∼0.86) are based on VolSurf+ (VS+) descriptors. Two of these models are Naïve Bayes (NB) classifiers using 4 descriptors that were selected through a new technique hereby first time extensively described.
Televised Entertainment-Education to Prevent Adolescent Alcohol Use

Alcohol use among adolescents is a concern in the Netherlands because of its high prevalence and risks. To discourage adolescents from drinking alcohol, a televised entertainment-education (E-E) intervention was developed. This study investigated responses of adolescents on perceived realism and enjoyment of the E-E intervention, as well as its impact on alcohol drinking behavior. Viewers perceived the E-E narratives to be credible and enjoyable but did not relate to the characters in the narratives. However, exposure to the E-E intervention predicted desired changes in alcohol drinking behavior, intentions to decrease alcohol use, and perceived normative pressure, especially in less educated viewers. These findings demonstrate that E-E is a promising strategy to target adolescent alcohol use. Future research will focus on the individual processes and story elements that account for the positive results.
Dissociation and Violent Criminal Behavior

The purpose of this paper is to examine a range of dissociative phenomena that occurs with violent offend ers. Two studies were conducted to assess the dissocia tive experience in a criminal act. The first assessed the variety of dissociative experiences an offender had be fore, during and following a criminal act. The second study evaluated, more particularly, the Multiple Person ality Disorder (MPD) and its relationship to criminal behavior.
Effects of Pairing Electric Shock with Reinforcement Delivered on a Variable-Interval Schedule

Gradually increased electric shock was superimposed on responding maintained on a VI 60-sec. schedule of reinforcement. Shock was contingent upon the reinforcement producing response and preceded reinforcement delivery. Following total response suppression, shock was removed and then reintroduced at selected intensities. The previously observed monotonic linear relationship between rate of responding and shock intensity was not recorded. Rather, post-reinforcement response bursts and two distinct patterns of response facilitation emerged.
Acting Superior But Actually Inferior?: Correlates and Consequences of Workplace Arrogance

Accounts of arrogant employees abound, yet there is little systematic research on arrogance within organizations. In response to this oversight, this article presents the findings from four studies. In Studies 1 and 2, the authors developed the Workplace Arrogance Scale and found support for its convergent and discriminant validity. In Study 3, the Workplace Arrogance Scale was included as part of a 360-degree performance feedback survey. Results revealed that there was satisfactory agreement between self- and other-ratings of arrogance. The authors also found that arrogance was negatively related to self- and other-rated task performance. Findings from Study 4 suggested that arrogance is negatively related to cognitive ability and self-esteem. The authors conclude by discussing the theoretical and practical implications of these findings.
Diversity and distribution of Blastocystis sp. subtypes in non-human primates

SUMMARY Blastocystis SSU-rDNA sequence data from 317 captive and free-living non-human primates (NHPs) representing 30 genera of apes, Old and New World (OW and NW) monkeys and prosimians were analysed to investigate subtype (ST) and allele distribution among hosts. Excluding 20 mixed ST infections, 27% of the sequences belonged to ST1, 22% to ST2, 34% to ST3, 1% to ST4, 4% to ST5, 11% to ST8, <1% to ST13 and 1% to ST15. The study confirmed cryptic host specificity of ST1 and ST3; conversely, considerable overlap in ST2 alleles exists among humans and NHPs. Subtype distribution in humans and NHPs differs mainly in that ST4 is rarely reported in NHPs while ST5 and ST8 are both unusual in humans. This may be due to host specificity and/or the apparent geographically restricted range of some subtypes. While the distribution of ST1, ST2 and ST3 was independent of NHP group or geographical association, ST5 was seen only in apes and OW monkeys and ST8 primarily in arboreal NHPs and only in species native to Asia or South America.
Finding the Right Fit: Understanding Health Tracking in Workplace Wellness Programs

Workplace health and wellness programs are increasingly integrating personal health tracking technologies, such as Fitbit and Apple Watch. Many question whether these technologies truly support employees in their pursuit of better wellness levels, raising objections about workplace surveillance and further blurring of boundaries between work and personal life. We conducted a study to understand how tracking tools are adopted in wellness programs and employees' opinions about these programs. We find that employees are generally positive about incentivized health tracking in the workplace, as it helps raise awareness of activity levels. However, there is a gap between the intentions of the programs and individual experiences and health goals. This sometimes results in confusion and creates barriers to participation. Even if this gap can be addressed, health tracking in the workplace will not be for everyone; this has implications for the design of both workplace wellness programs and tracking technologies.
Decreased energy expenditure during prolonged sub-maximal exercise in a warm environment

Abstract The purpose of this study was to investigate the influence of a warm environment on thermoregulation and energy expenditure during sub-maximal prolonged exercise in humans. Six healthy male subjects cycled for 120 min at an intensity of 60% maximal oxygen uptake (Vo2max) at three environmental temperatures (10°C, CT; 20°C, MT; and 30°C, WT). Although oxygen uptake at WT showed a significantly lower value compared to those at MT and CT, no significant differences of respiratory exchange ratio were observed among the three environmental trials. A remarkable decrease in total energy expenditure during the 120-min exercise at WT was observed in comparison with those at MT and CT (p<0.05). Changes in rectal temperature, mean skin temperature, and mean body temperature at WT were significantly higher than those at both MT and CT. Although increases in mean body temperature from rest every five minutes during exercise were not different among three environmental temperatures, mean energy expenditures every five minutes at WT were lower compared with those at MT and CT (p<0.05). These results suggest that the increase in energy expenditure for physical exertion is substantially reduced during prolonged sub-maximal exercise in a warm environment. This acute alteration in the energy metabolism may contribute to inhibition of excess heat production and enable prolonged exercise in a warm environment.