Miracle-dz/UniFAR-FTUs huggingface dataset:
Impacts of Topology and Traffic Pattern on Capacity of Hybrid Wireless Networks

In this paper, we investigate the throughput capacity in wireless hybrid networks with various network topologies and traffic patterns. Specifically, we consider n randomly distributed nodes, out of which there are n source nodes and nd (0 < d < 1) randomly chosen destination nodes, together with nb (0 < b < 1) base stations in a network area of [0, nw] times [0, n1-w] (0 < w les 1/2 ). We first study the throughput capacity when the base stations are regularly placed and their transmission power is large enough for them to directly transmit to any nodes associated with them. We show that a per-node throughput of max{min{nb-1, nd-1}, min {nw-1/radiclog n, nd-1}} bits/sec is achievable by all nodes. We then investigate the throughput capacity when the base stations are uniformly and randomly placed, and their transmission power is as small as that of the normal nodes. We present that each node can achieve a throughput of max{min{nb-1/log n, nd-1}, min {nw-1/radiclog n, nd-1}} bits/sec. In both settings, we observe that only when d > b and d > w, the maximum achievable throughput can be determined by both the number of base stations and the shape of network area. In all the other cases, the maximum achievable throughput is only constrained by the number of destination nodes. Moreover, the results in these two settings are the same except for the case d > b > w, in which the random placement of base stations will cause a degradation factor of log n on the maximum achievable throughput compared to the regular placement. Finally, we also show that our results actually hold for different power propagation models.
Editing out five Serpina1 paralogs to create a mouse model of genetic emphysema

Significance Chronic obstructive pulmonary disease affects 10% of the worldwide population, and the leading genetic cause is a genetic disease, α-1 antitrypsin (AAT) deficiency. Humans have only one gene that codes for the AAT protein, but mice have up to six, which made it impossible for decades to create a mouse model of the disease. Here we succeeded in creating this mouse model using CRISPR technology to target all of the mouse genes at once. Importantly, this mouse model spontaneously develops lung disease and recapitulates many aspects of the human disease. We anticipate that this model will be highly relevant not only to the preclinical development of therapeutics for AAT deficiency, but also to emphysema and smoking research. Chronic obstructive pulmonary disease affects 10% of the worldwide population, and the leading genetic cause is α-1 antitrypsin (AAT) deficiency. Due to the complexity of the murine locus, which includes up to six Serpina1 paralogs, no genetic animal model of the disease has been successfully generated until now. Here we create a quintuple Serpina1a–e knockout using CRISPR/Cas9-mediated genome editing. The phenotype recapitulates the human disease phenotype, i.e., absence of hepatic and circulating AAT translates functionally to a reduced capacity to inhibit neutrophil elastase. With age, Serpina1 null mice develop emphysema spontaneously, which can be induced in younger mice by a lipopolysaccharide challenge. This mouse models not only AAT deficiency but also emphysema and is a relevant genetic model and not one based on developmental impairment of alveolarization or elastase administration. We anticipate that this unique model will be highly relevant not only to the preclinical development of therapeutics for AAT deficiency, but also to emphysema and smoking research.
Reevaluation of Mandibular Morphometry According to Age, Gender, and Side

Aim: This study aims to reevaluation the linear and angular measurements of mandibles with multidetector computed tomography (MDCT) that is a new method and used frequently in recent years. Materials and Methods: The archived MDCT images of 100 adult patients (age range, 15–74 years) without mandibular operation and trauma history were evaluated retrospectively. Mandibular ramus heights, maximal mandibular length, mandibular symphysis height, mandibular angles, and mandibular foramen distance measurements were performed on MDCT images. All measurement parameters were analyzed by gender, age groups, and sides. Results: Mandibular linear length measurements were higher in males than in females (P < 0.05). Only mandibular symphysis height was statistically significantly different in age groups (P < 0.05). The Angle 1 (gonial angle) was found to be significantly higher in females (P < 0.05). The Angle 3 (right condyle–gnathion–left condyle angle) was observed to be significantly higher in the 60+ age group (P < 0.05). The 3 of the mandibular foramen measurements (distance from the front edge, distance to gonion, and height of lingula) were found to be higher in males than in females (P < 0.05). There were no significant differences according to age groups in these measurements. The lengths of the mandibular canals were higher in males (44.72 mm) than in females (41.68 mm). There was no statistically significant difference was found between gender, age groups, and sides of mandibular canal length. Conclusion: The MDCT was found to be a reliable method for the detection of mandibular morphometry when compared with the results of other radiographic images studies.
THE INFLUENCE OF PULVERIZED-FUEL ASH UPON THE HYDRATION CHARACTERISTICS AND CERTAIN PHYSICAL PROPERTIES OF A PORTLAND CEMENT PASTE

In order to examine the effects produced by the presence of pfa upon the hydration characteristics of an ordinary portland cement, comparisons were obtained using two equivalent pastes. One of these pastes was prepared with an ordinary portland cement and the other with a blend containing 30 parts by weight of pfa and 70 parts by weight of the opc. Both pastes were made so as to have a water to solids ratio of 0.47 by weight. The chemical composition and the physical characteristics of the starting materials are shown. The following quantitative measurements were made after 0.25, 0.5, 1, 1.5, 2, 7, 14, 28, 65, 100, 275 and 365 days hydration at room temperature: 1) compressive strength (at ages greater than 1.5 days); 2) total porosity (at ages greater than 1.5 days); 3) chemically bound water; 4) calcium hydroxide (portlandite) content; 5) hydration of the individual cement phases; 6) reaction of the "glassy" phase in the pfa. Two distinct mechanisms are shown to occur. At early ages the pfa does not make a strong contribution to strength but, as a fine powder, it accelerates the hydration of the cement. The pozzolanic reaction becomes apparent at normal temperature if curing has continued beyond fourteen days. (TRRL)
Experimental Investigation of the Wake and the Wingtip Vortices of a UAV Model

An experimental investigation of the wake of an Unmanned Aerial Vehicle (UAV) model using flow visualization techniques and a 3D Laser Doppler Anemometry (LDA) system is presented in this work. Emphasis is given on the flow field at the wingtip and the investigation of the tip vortices. A comparison of the velocity field is made with and without winglet devices installed at the wingtips. The experiments are carried out in a closed-circuit subsonic wind tunnel. The flow visualization techniques include smoke-wire and smoke-probe experiments to identify the flow phenomena, whereas for accurately measuring the velocity field point measurements are conducted using the LDA system. Apart from the measured velocities, vorticity and circulation quantities are also calculated and compared for the two cases. The results help to provide a more detailed view of the flow field around the UAV and indicate the winglets’ significant contribution to the deconstruction of wing-tip vortex structures.
The role of eating frequency on total energy intake and diet quality in a low-income, racially diverse sample of schoolchildren

Abstract Objective The relationship of meal and snacking patterns with overall dietary intake and relative weight in children is unclear. The current study was done to examine how eating, snack and meal frequencies relate to total energy intake and diet quality. Design The cross-sectional associations of eating, meal and snack frequencies with total energy intake and diet quality, measured by the Healthy Eating Index 2005 (HEI-2005), were examined in separate multivariable mixed models. Differences were examined between elementary school-age participants (9–11 years) and adolescents (12–15 years). Setting Two non-consecutive 24 h diet recalls were collected from children attending four schools in the greater Boston area, MA, USA. Subjects One hundred and seventy-six schoolchildren, aged 9–15 years. Results Overall, 82 % of participants consumed three daily meals. Eating, meal and snack frequencies were statistically significantly and positively associated with total energy intake. Each additional reported meal and snack was associated with an 18·5 % and a 9·4 % increase in total energy intake, respectively (P<0·001). The relationships of eating, meal and snack frequencies with diet quality differed by age category. In elementary school-age participants, total eating occasions and snacks increased HEI-2005 score. In adolescents, each additional meal increased HEI-2005 score by 5·40 points (P=0·01), whereas each additional snack decreased HEI-2005 score by 2·73 points (P=0·006). Conclusions Findings suggest that snacking increases energy intake in schoolchildren. Snacking is associated with better diet quality in elementary school-age children and lower diet quality in adolescents. Further research is needed to elucidate the role of snacking in excess weight gain in children and adolescents.
Web page classification: Features and algorithms

Classification of Web page content is essential to many tasks in Web information retrieval such as maintaining Web directories and focused crawling. The uncontrolled nature of Web content presents additional challenges to Web page classification as compared to traditional text classification, but the interconnected nature of hypertext also provides features that can assist the process. As we review work in Web page classification, we note the importance of these Web-specific features and algorithms, describe state-of-the-art practices, and track the underlying assumptions behind the use of information from neighboring pages.
The Potency of the First Two Cleavage Cells in Echinoderm Development . Experimental Production of Partial and Double Formations " ( 1891-1892 ) , by Hans Driesch

Hans Adolf Eduard Driesch was a late-nineteenth and early-twentieth century philosopher and developmental biologist. In the spring of 1891 Driesch performed experiments using twocelled sea urchin [5] (Echinus microtuberculatus) embryos, the results of which challenged the then-accepted understanding of embryo development. Driesch showed that the cells of an early embryo, when separated, could each continue to develop into normal larval forms. This finding contrasted with Wilhelm Roux [6]'s experiments with frog [7] eggs from which Roux had concluded that embryonic cells have predetermined fates? an embryonic cell couldn't form into one thing when separated from other embryonic cells and form into something else when left unseparated. To Roux, embryos were mosaics of cells, all of which were important and necessary for viable [8] embryos to form. Driesch, in contrast, showed that individual cells resulting from cleavage of the fertilized egg [9] were all able to form into viable [8] embryos, and not just into predetermined parts as Roux believed.
Use of a Thin-Layer Technique in Thyroid Fine Needle Aspiration

OBJECTIVE To investigate the efficacy of the ThinPrep Processor (Cytyc Corporation, Boxborough, Massachusetts, U.S.A) in fine needle aspiration (FNA) of thyroid gland lesions. STUDY DESIGN This study included 459 thyroid FNA specimens obtained from patients who came to our endocrinology department with various thyroid disorders over 3 years. The cytologic material was prepared using both the conventional and ThinPrep method in the first 2 years (285 cases), while in the last one only the ThinPrep method was used (1 74 cases). The smears were stained using a modified Papanicolaou procedure and May-Grünwald-Giemsa stain. Immunocytochemistry was performed on thin-layer slides using specific monoclonal antibodies when needed. Thin-layer and direct smear diagnoses were compared with the final cytologic or histologic diagnoses, when available. RESULTS Our cases included 279 adenomatoid nodules, 15 cases of Hashimoto thyroiditis, 45 follicular neoplasms, 14 Hürthle cell tumors, 58 papillary carcinomas and 1 5 anaplastic carcinomas. Thin-layer preparations showed a trend toward a lower proportion of inadequate specimens and a lower false negative rate. Cytomorphologic features showed some differences between the 2 methods. Colloid was less frequently observed on ThinPrep slides, while nuclear detail and micronucleoli were more easily detected with this technique. Moreover, ThinPrep appeared to be the appropriate method for the use of ancillary techniques in suspicious cases. CONCLUSION Thin-layer cytology improves the diagnostic accuracy of thyroid FNA and offers the possibility of performing new techniques, such as immunocytochemistry, on the same sample in order to detect malignancy as well as the type and origin of thyroid gland neoplasms.
No evidence that boron influences tree species distributions in lowland tropical forests of Panama.

It was recently proposed that boron might be the most important nutrient structuring tree species distributions in tropical forests. Here we combine observational and experimental studies to test this hypothesis for lowland tropical forests of Panama. Plant-available boron is uniformly low in tropical forest soils of Panama and is not significantly associated with any of the > 500 species in a regional network of forest dynamics plots. Experimental manipulation of boron supply to seedlings of three tropical tree species revealed no evidence of boron deficiency or toxicity at concentrations likely to occur in tropical forest soils. Foliar boron did not correlate with soil boron along a local scale gradient of boron availability. Fifteen years of boron addition to a tropical forest increased plant-available boron by 70% but did not significantly change tree productivity or boron concentrations in live leaves, wood or leaf litter. The annual input of boron in rainfall accounts for a considerable proportion of the boron in annual litterfall and is similar to the pool of plant-available boron in the soil, and is therefore sufficient to preclude boron deficiency. We conclude that boron does not influence tree species distributions in Panama and presumably elsewhere in the lowland tropics.
Polymethoxyflavones from Nicotiana plumbaginifolia (Solanaceae) Exert Antinociceptive and Neuropharmacological Effects in Mice

Polymethoxylavones (PMFs) are known to exhibit significant anti-inflammatory and neuroprotective properties. Nicotiana plumbaginifolia, an annual Bangladeshi herb, is rich in polymethoxyflavones that possess significant analgesic and anxiolytic activities. The present study aimed to determine the antinociceptive and neuropharmacological activities of polyoxygenated flavonoids namely- 3,3′,5,6,7,8-hexamethoxy-4′,5′-methylenedioxyflavone (1), 3,3′,4′,5′,5,6,7,8-octamethoxyflavone (exoticin) (2), 6,7,4′,5′-dimethylenedioxy-3,5,3′-trimethoxyflavone (3), and 3,3′,4′,5,5′,8-hexamethoxy-6,7-methylenedioxyflavone (4), isolated and identified from N. plumbaginifolia. Antinociceptive activity was assessed using the acetic-acid induced writhing, hot plate, tail immersion, formalin and carrageenan-induced paw edema tests, whereas neuropharmacological effects were evaluated in the hole cross, open field and elevated plus maze test. Oral treatment of compounds 1, 3, and 4 (12.5–25 mg/kg b.w.) exhibited dose-dependent and significant (p < 0.01) antinociceptive activity in the acetic-acid, formalin, carrageenan, and thermal (hot plate)-induced pain models. The association of ATP-sensitive K+ channel and opioid systems in their antinociceptive effect was obvious from the antagonist effect of glibenclamide and naloxone, respectively. These findings suggested central and peripheral antinociceptive activities of the compounds. Compound 1, 3, and 4 (12.5 mg/kg b.w.) demonstrated significant (p < 0.05) anxiolytic-like activity in the elevated plus-maze test, while the involvement of GABAA receptor in the action of compound 3 and 4 was evident from the reversal effects of flumazenil. In addition, compounds 1 and 4 (12.5–25 mg/kg b.w) exhibited anxiolytic activity without altering the locomotor responses. The present study suggested that the polymethoxyflavones (1–4) from N. Plumbaginifolia could be considered as suitable candidates for the development of analgesic and anxiolytic agents.
Atopy Associated With Positive Patch Test and Possible Allergic Contact Dermatitis

Background: Atopy is a genetic predisposition to the development of allergic reactions and the increased production of immunoglobulin E (IgE) upon exposure to environmental antigens. Clinical manifestations of atopy include asthma, atopic dermatitis (AD), and allergic rhinoconjunctivitis (ARC). Objective: To determine if cutaneous delayed hypersensitivity reactions (CDHRs) as assessed by patch testing are higher among patients with a history of atopy and with a familial predisposition to atopy. Methods: For this study, we reviewed the patch test database of the UBC Contact Dermatitis Clinic over a 4-year time span. A personal history of asthma, AD, and ARC was recorded. In addition, a family history was obtained and manifestations of atopy in family members were noted. Results: A total of 1515 patients were included in this study. Our data show that the odds ratio (OR) of a positive patch test with a personal history of atopy was 1.39, while the OR of a positive patch test with a family history of atopy was 1.69. Conversely, a personal history of respiratory atopy did not significantly affect the probability of a positive patch test, with an OR of 1.03. Conclusion: We conclude from our study that patients with a personal or family history of atopy have an increased risk of allergic contact dermatitis (ACD). These results provide further evidence for the link between atopy and ACD and suggest that children of atopic parents should avoid potential contact allergens and would likely benefit from prophylactic emollient use.
A Framework for Partitioning and Execution of Data Stream Applications in Mobile Cloud Computing

The advances in technologies of cloud computing and mobile computing enable the newly emerging mobile cloud computing paradigm. Three approaches have been proposed for mobile cloud applications: 1) extending the access to cloud services to mobile devices; 2) enabling mobile devices to work collaboratively as cloud resource providers; 3) augmenting the execution of mobile applications on portable devices using cloud resources. In this paper, we focus on the third approach in supporting mobile data stream applications. More specifically, we study the computation partitioning, which aims at optimizing the partition of a data stream application between mobile and cloud such that the application has maximum speed/throughput in processing the streaming data. To the best of our knowledge, it is the first work to study the partitioning problem for mobile data stream applications, where the optimization is placed on achieving high throughput of processing the streaming data rather than minimizing the make span of executions in other applications. We first propose a framework to provide runtime support for the dynamic partitioning and execution of the application. Different from existing works, the framework not only allows the dynamic partitioning for a single user but also supports the sharing of computation instances among multiple users in the cloud to achieve efficient utilization of the underlying cloud resources. Meanwhile, the framework has better scalability because it is designed on the elastic cloud fabrics. Based on the framework, we design a genetic algorithm to perform the optimal partition. We have conducted extensive simulations. The results show that our method can achieve more than 2X better performance over the execution without partitioning.
Disassociation between brain activation and executive function in fragile X premutation females

Executive dysfunction has been demonstrated among premutation (PM) carriers (55–199 CGG repeats) of the Fragile X mental retardation 1 (FMR1) gene. Further, alterations to neural activation patterns have been reported during memory and comparison based functional magnetic resonance imaging (fMRI) tasks in these carriers. For the first time, the relationships between fMRI neural activation during an interleaved ocular motor prosaccade/antisaccade paradigm, and concurrent task performance (saccade measures of latency, accuracy and error rate) in PM females were examined. Although no differences were found in whole brain activation patterns, regions of interest (ROI) analyses revealed reduced activation in the right ventrolateral prefrontal cortex (VLPFC) during antisaccade trials for PM females. Further, a series of divergent and group specific relationships were found between ROI activation and saccade measures. Specifically, for control females, activation within the right VLPFC and supramarginal gyrus correlated negatively with antisaccade latencies, while for PM females, activation within these regions was found to negatively correlate with antisaccade accuracy and error rate (right VLPFC only). For control females, activation within frontal and supplementary eye fields and bilateral intraparietal sulci correlated with prosaccade latency and accuracy; however, no significant prosaccade correlations were found for PM females. This exploratory study extends previous reports of altered prefrontal neural engagement in PM carriers, and clearly demonstrates dissociation between control and PM females in the transformation of neural activation into overt measures of executive dysfunction. Hum Brain Mapp 38:1056–1067, 2017. © 2016 Wiley Periodicals, Inc.
New Insights into Clostridium difficile (CD) Infection in Latin America: Novel Description of Toxigenic Profiles of Diarrhea-Associated to CD in Bogotá, Colombia

Clostridium difficile (CD) produces antibiotic associated diarrhea and leads to a broad range of diseases. The source of CD infection (CDI) acquisition and toxigenic profile are factors determining the impact of CD. This study aimed at detecting healthcare facility onset- (HCFO) and community-onset (CO) CDI and describing their toxigenic profiles in Bogotá, Colombia. A total of 217 fecal samples from patients suffering diarrhea were simultaneously submitted to two CDI detection strategies: (i) in vitro culture using selective chromogenic medium (SCM; chromID, bioMérieux), followed verification by colony screening (VCS), and (ii) molecular detection targeting constitutive genes, using two conventional PCR tests (conv.PCR) (conv.16S y conv.gdh) and a quantitative test (qPCR.16s). The CD toxigenic profile identified by any molecular test was described using 6 tests independently for describing PaLoc and CdtLoc organization. High overall CDI frequencies were found by both SCM (52.1%) and conv.PCR (45.6% for conv.16S and 42.4% for conv.gdh), compared to reductions of up to half the frequency by VCS (27.2%) or qPCR.16S (22.6%). Infection frequencies were higher for SCM and conv.16S regarding HCFO but greater for CO concerning conv.gdh, such differences being statistically significant. Heterogeneous toxigenic profiles were found, including amplification with lok1/3 primers simultaneously with other PaLoc markers (tcdA, tcdB or tcdC). These findings correspond the first report regarding the differential detection of CDI using in vitro culture and molecular detection tests in Colombia, the circulation of CD having heterogeneous toxigenic profiles and molecular arrays which could affect the impact of CDI epidemiology.