Miracle-dz/UniFAR-FTUs huggingface dataset:
Correction of eyelid anomalies in pachydermoperiostosis.

PURPOSE Pachydermoperiostosis, or primary hypertrophic osteoarthropathy, is a rare disease, characterized by pachydermia, acropathy, and periostosis. The authors propose the surgical correction of the eyelid anomalies in one stage. METHODS A 30-year-old patient with moderate blepharoptosis (3 mm) and increased vertical and horizontal dimensions of the upper eyelids underwent fusiform transverse excision of skin, orbicularis muscle, and tarsus; shortening of the levator palpebrae superioris apeoneurosis by 13 mm; and 8-mm-wide wedge excision. RESULTS Histologic findings included hyperplasia of the tarso-conjunctival plate, obstructive cystic dilatation of the sebaceous glands, extensive fibrosis, and granulomatous reaction. Satisfactory functional and aesthetic results were observed after surgery. CONCLUSION Upper eyelid anomalies in pachydermoperiostosis can be corrected in a single stage bilaterally with good results.
Association of Helicobacter Pylori VacA Gene Polymorphisms and CagA Gene with Clinical Outcome in Dyspeptic Patients.

Background: Gastroduodenal diseases have been associated with Helicobacter pylori infection. Cytotoxin-associated gene A (cagA) and different isoforms of vacuolating cytotoxin (vacA) gene have been associated with disease severity. The prevalence and association of these genotypes with severity of disease differ geographically. The aim of this study was to determine the prevalence of the cagA and vacA variants of Helicobacter pylori isolated from dyspeptic patients in Kenya and to assess their association with clinical outcome. Methods: One hundred and twenty seven dyspeptic patients were enrolled into the study. H. pylori positivity was determined by histology and molecular diagnostic method directly from the gastric biopsies collected. The presence of cagA and vacA variants was analyzed by polymerase chain reaction (PCR) from the eighty H. pylori positive samples with various gastroduodenal diseases. Results: The H. pylori DNA was detected in 62.99% of the dyspeptic patients. The prevalence of cagA gene was 48.75% among the positive samples and was not significantly associated with the gastroduodenal diseases. The less virulent vacA alleles: m2, i2 and s2 were most occurring at 65%, 52% and 49%, respectively. The vacA allele m1, i1, and s1 were significantly associated with peptic ulcer, intestinal metaplasia and gastric cancer, all at P < 0.05. Conclusion: The less toxigenic vacA isoforms s2, m2 and i2 are highly distributed in Kenya. We confirmed the significant association of the vac s1, m1 and i1 with gastric cancer and peptic ulcer. We cannot rule out the possibility of the presence of unidentified strain or certain host or environmental factors that trigger H. pylori-induced cancer and peptic ulceration.
T Cell Recognition Peptides That Alter TCR Binding and Residues Generates Heteroclitic Modification of MHC Anchor

doi:10.4049/jimmunol.1000629 online Jul 16, 2010; 2010;185;2600-2610; originally published J. Immunol. Price and Andrew K. Sewell Skowera, Mark Peakman, Linda Wooldridge, David A. Ekeruche, Emma Gostick, Katherine J. Adams, Ania Mathew Clement, John J. Miles, Kristin Ladell, Julia David K. Cole, Emily S. J. Edwards, Katherine K. Wynn, T Cell Recognition Peptides That Alter TCR Binding and Residues Generates Heteroclitic Modification of MHC Anchor
The magnitude of obesity and metabolic syndrome among diabetic chronic kidney disease population: A nationwide study

Background Although the prevalence of obesity and metabolic syndrome (MetS) among dialysis patients has been exceeding than general population, little is known regarding obesity and MetS in non-dialysis chronic kidney disease (CKD). We aimed to find the magnitude of obesity and MetS and their associations with impaired renal function among type 2 diabetes mellitus (T2DM) patients. Methods A national survey of T2DM patients was collected in the Thai National Health Security Office database during 2014–5. The sampling frame was designated as distinct geographic regions throughout the country. A stratified two-stage cluster sampling was used to select the study population. Anthropometry and 12-hour fasting blood samples were obtained by trained personnel. BMI of ≥25 kg/m2 was classified as obesity. MetS was defined as having elevated waist circumference (>90 and >80 cm in men and women, respectively) plus any two of the followings: triglyceride ≥150 mg/dL, HDL-C <40 in men or <50 mg/dL in women, blood pressure ≥130/85 mmHg, and fasting blood sugar ≥100 mg/dL. CKD was defined as an impaired renal function (eGFR <60 mL/min/1.73m2 according to the CKD-EPI equation). Logistic regression analysis was performed to examine the relationship between obesity and MetS with the presence of CKD. Results A total of 32,616 diabetic patients were finally recruited from 997 hospitals. The mean age was 61.5±10.9 years with 67.5% women. Of the participants, 35.4% were CKD patients. The prevalence of obesity was 46.5% in CKD and 54.1% in non-CKD patients with T2DM (p<0.001). In contrast, the prevalence of MetS in CKD patients was higher than their non-CKD counterparts (71.3 vs 68.8%, p<0.001). Moreover, there was an association between the prevalence of MetS with CKD stage from 3a to 5 (70.1, 72.3, 73.4, and 72.7%, respectively, p trend = 0.02). MetS, but not obesity, had a significant association with CKD in T2DM patients after adjusting for age, sex, and comorbidities [OR 1.14; 95% CI 1.06–1.22, p<0.001]. When stratified by each component of MetS, only high serum triglyceride and low HDL-C levels were increased in patients with CKD stage 4 and 5 compared with CKD stage 3 (p<0.001) and had a significant relationship with impaired renal function. Conclusion There were relatively high prevalences of both obesity and MetS in T2DM patients. A higher prevalence of MetS, but lower prevalence of obesity, was observed among diabetic CKD group compared with their non-CKD counterparts. MetS, as a surrogate of insulin resistance, appeared to be more important than obesity in the development of impaired renal function in diabetic population.
“Facts, Not Fear”

Trust in many government organizations is low, creating a challenging environment for communication during outbreaks of emerging infectious diseases, like Ebola. In a thematic analysis of 1,010 tweets and four Twitter chats during the 2014-2015 Ebola outbreak, we found that the Centers for Disease Control and Prevention emphasized organizational competence, extant protocol, and facts about transmission to manage public fear. We argue that an emphasis on certainty in a rapidly changing situation leaves organizations vulnerable to charges of unpreparedness or obfuscation. Our results also speak to the contested definition of engagement online, particularly during health crises.
Laser phototherapy induces angiogenesis in the periodontal tissue after delayed tooth replantation in rats

Background Laser phototherapy (LPT) has been suggested as a new therapeutic tool to improve the repair of replanted teeth. However, its effects and mechanism of action are not yet completely understood. Objectives This study evaluated histologically the effect of laser phototherapy (LPT) λ808 and λ660 nm on angiogenesis in the periodontal tissue of replanted teeth in rats. Material and Methods Twenty maxillary right incisors were extracted from twenty Wistar rats and randomly assigned to four groups (n = 5): PN – teeth were stored in paper napkin for 45 min; WM – teeth were immersed in 20 ml of UHT whole cow milk for 45 min; PNL and WML – teeth received the same treatment described for PN and WM, respectively, plus LPT at λ808 and λ660 nm. All root canals were prepared and filled with calcium hydroxide paste. The animals were euthanized 15 days after tooth replantation and angiogenesis was scored by blood vessel counting in the area of periodontal ligament and alveolar bone, using the ImageJ software. Data were analyzed statistically by ANOVA and Tukey’s test (α = 5%). Results LPT at λ808 and λ660 nm caused significant increased angiogenesis on irradiated groups (PNL and WML) when compared to the non-irradiated groups (PN and WM) (p<0.05). There was no statistically significant difference between PN and WM as well as between PNL and WML (p>0.05). Conclusions LPT is capable of stimulating angiogenesis in vivo in the periodontal tissue of replanted teeth. Key words:Angiogenesis, lasers, tooth avulsion, tooth replantation, wound healing.
Multiparty Delegated Quantum Computing

Quantum computing has seen tremendous progress in the past few years. However, due to limitations in the scalability of quantum technologies, it seems that we are far from constructing universal quantum computers for everyday users. A more feasible solution is the delegation of computation to powerful quantum servers on the network. This solution was proposed in previous studies of blind quantum computation, with guarantees for both the secrecy of the input and of the computation being performed. In this work, we further develop this idea of computing over encrypted data, to propose a multiparty delegated quantum computing protocol in the measurement-based quantum computing framework. We prove the security of the protocol against a dishonest server and against dishonest clients, under the assumption of common classical cryptographic constructions.
Implementing Treat‐to‐Target Practices for Chronic Pain Through Shared Decision Making: Requisites, Prospects, and Challenges

Treat‐to‐target (T2T) includes a target or goal, standard symptom assessment, and a treatment decision. In specialties that threat chronic pain, T2T is expected to be implemented collaboratively. The ability of patients to participate fully has been questioned, but these concerns have not been demonstrated empirically. The current study examined how patient self‐assessed symptom measures and illness beliefs affect their willingness to change their current treatment.
Creative Self-Beliefs: Their Nature, Development, and Correlates

People's convictions about their own abilities and psychological characteristics are of crucial significance in regard to their actual functioning, including creativity. Historically, self-beliefs (which include aspects of self-efficacy, self-concept, and self-esteem) have most frequently been conceptualized from two different perspectives in psychology: (1) humanistic and neo-humanistic positive psychology and (2) cognitive and social-cognitive psychology. The first approach is strongly grounded in the works of Maslow (1958), Rogers (1954), and Fromm (1959) and was continued by Csikszentmihalyi (1997) and others (e.g., Richards, 2010). This approach often conceptualizes the formation of identity as a creative process, or, reciprocally, posits that creativity represents a mechanism of self-understanding, self-fulfillment, or self-actualization. The second approach, which encompasses Bandura's (1997) classic work, considers the process of acquiring knowledge about one's self as an activity that is largely cognitive and is conditioned by interactions with the social world. Other established approaches include educational perspectives focusing on the structure of self-concepts (e.g., Marsh, 1990), developmental approaches (Eccles, 1983), and cultural psychology approaches within the field of creativity (Glăveanu & Tanggaard, 2014). The present chapter reviews and summarizes key data about the role and significance of self-beliefs about one's creativity (creative self-beliefs [CSB]), with a focus on the sociocognitive approach. Specifically, the purpose of this chapter is to articulate theories and research on CSB, and to outline possible relationships that may exist between a wide and heterogeneous range of facets of both CSB and creativity. We focus our review principally on little-c and mini-c creativity in children and adolescents, rather than on professional (Pro-C) or eminent (Big-C) creativity (Kaufman & Beghetto, 2009). Indeed, the significance of self-beliefs for “everyday” creativity (e.g., a child's creative thinking, solving everyday problems, tackling issues that require individual inventions) is truly intriguing: to what extent do children's, adolescents’, and adults’ convictions about their creative abilities influence their motivation to undertake creative activities? How are CSBs formed? How can CSBs be strengthened and why should they be supported? This chapter addresses these questions, among others. Although we focus on everyday creativity, it is worth noting that eminent creativity may also suggest and inform inquiries about CSBs. For example, eminent individuals tend to be strongly convinced about their own creative abilities (Barron & Harrington, 1981), as a result of their successes and the feedback they obtain from their fields.
Reducing urinary catheter use: a protocol for a mixed methods evaluation of an electronic reminder system in hospitalised patients in Australia

Introduction Despite advances in infection prevention and control, catheter-associated urinary tract infections (CAUTIs) are common and remain problematic. Prolonged urinary catheterisation is the main risk factor for development of CAUTIs; hence, interventions that target early catheter removal warrant investigation. The study’s objectives are to examine the efficacy of an electronic reminder system, the CATH TAG, in reducing urinary catheter use (device utilisation ratio) and to determine the effect of the CATH TAG on nurses’ ability to deliver patient care. Methods and analysis This study uses a mixed methods approach in which both quantitative and qualitative data will be collected. A stepped wedge randomised controlled design in which wards provide before and after observations will be undertaken in one large Australian hospital over 24 weeks. The intervention is the use of the CATH TAG. Eligible hospital wards will receive the intervention and act as their own control, with analysis undertaken of the change within each ward using data collected in control and intervention periods. An online survey will be administered to nurses on study completion, and a focus group for nurses will be conducted 2 months after study completion. The primary outcomes are the urinary catheter device utilisation ratio and perceptions of nurses about ease of use of the CATH TAG. Secondary outcomes include a reduced number of cases of catheter-associated asymptomatic bacteriuria, a reduced number of urinary catheters inserted per 100 patient admissions, perceptions of nurses regarding effectiveness of the CATH TAG, changes in ownership/interest by patients in catheter management, as well as possible barriers to successful implementation of the CATH TAG. Ethics and dissemination Approval has been obtained from the Human Research Ethics Committees of Avondale College of Higher Education (2017:15) and Queensland Health (HREC17QTHS19). Results will be disseminated via peer-reviewed journals and conference presentations. Trial registration number ACTRN12617001191381 (Pre-results).
Microanatomical Location of Hyaluronic Acid Gel Following Injection of the Temporal Hollows

Purpose: To examine the microanatomical location of hyaluronic acid gel injected within the temporal hollows of cadaver specimens. Methods: The temporal hollows were injected subcutaneously with hyaluronic acid gel in 6 fresh frozen human cadaver hemifaces. Temporal soft tissues were dissected to a preperiosteal plane and fixated in 95% alcohol. A soft tissue section extending from skin to temporal bone was obtained for each specimen. Histologic examination was performed using hematoxylin and eosin stain. Results: In 5 of 6 specimens, at least 95% of the hyaluronic acid was located within the subcutaneous fat. In 1 of 6 specimens, approximately 35% of the material was located within the subcutaneous fat and 60% was located within the superficial temporal fascia. Two specimens had 5% located within the temporalis muscle. In 1 specimen, hyaluronic acid was found to encompass a superficial muscular artery within the superficial temporal fascia. Conclusions: This study elucidates the location of hyaluronic acid gel after subcutaneous injection within the temporal hollow. Histology confirmed consistent placement of the gel within the subcutaneous tissues, but it also showed that injection in this region may produce unintended deeper location of filler, and a significant perivascular collection of the material. The proximity of dense temporal fascial and muscle arterial networks in this region may pose risk for perivascular injection and associated complications.
Using ε-Dominance for Hidden and Degenerated Pareto-Fronts

Scalable multi-objective test problems are known to be useful in testing and analyzing the abilities of algorithms. In this paper we focus on test problems with degenerated Pareto-fronts and provide an in-depth insight into the properties of some problems which show these characteristics. In some of the problems with degenerated fronts such as Distance Minimization Problem (DMP) with the Manhattan metric, it is very difficult to dominate some of the non-optimal solutions as the optimal solutions are hidden within a set of so called pseudo-optimal solutions. Hence the algorithms based on Pareto-domination criterion are shown to be inefficient. In this paper, we explore the pseudo-optimal solutions and examine how and why the use of ε-dominance can help to achieve a better approximation of the hidden Pareto-fronts or of degenerated fronts in general. We compare the performance of the ε-MOEA with 3 other algorithms (NSGA-II, NSGA-III and MOEA/D) and show that ε- dominance performs better when dealing with pseudo-optimal kind of solutions. Furthermore, we analyze the performance on the WFG3 test problem and illustrate the advantages and disadvantages of ε-dominance for this degenerated problem.
Evaluation of Apical Sealing Ability of Three Different Root Canal Sealers

Aim: Evaluation of apical sealing ability of Resilon with Epiphany sealer, gutta-percha with AH plus sealerand gutta-percha with MTA fillapex sealer using dye penetration method. Introduction – Success of root canal treatment highly depends of three dimensional obturation of the root canal system. Solid core gutta percha and sealers is preferred method of obturation of the root canal system. None of the available method are capable of providing a fluid tight seal. Material and Methods: Thirty freshly extracted single rooted premolars were taken and randomly divided into three groups. These teeth were then obturated using following methods. Group Igutta -percha with AH plus sealer, Group IIgutta-percha with MTA fillapex sealer, Group IIIResilon with Epiphany sealer. All specimens were stored in 100% relative humidity for 48hrs. The teeth were then stored in RhodamineB dye for 24hrs and then were sectioned and observed under stereomicroscope. Results: Data obtained was analysed using Mann whiteny ‘u’ test.There was statistically significant difference among the groups. Group III showed minimum dye leakage and group II showed maximum dye leakage. Conclusion: Resilon Epiphany system showed better apical sealing of the root canal as compared to AH plus and MTA fillapex sealer.
Executive function in cancer patients with posttraumatic stress disorder

Background Cancer patients with posttraumatic stress disorder can lead to their noncompliant behaviors. However, less is known about the neurocognitive functioning of posttraumatic stress disorder in general cancer types or patient populations. The current study attempted to examine the prevalence of posttraumatic stress disorder and their relationships with executive function in individuals with cancer. Methods A total of 285 cancer patients with posttraumatic stress disorder and 150 healthy individuals were recruited for the present study. The Clinician Administered PTSD Scale, Tower of Hanoi, Wisconsin Card Sorting Test, and Wechsler Adult Intelligence Scale-Revised Chinese revision were administered to all participants. Results Significant differences in the score of Tower of Hanoi, Wisconsin Card Sorting Test, and Wechsler Adult Intelligence Scale-Revised Chinese revision were observed between the posttraumatic stress disorder group and the healthy control group (p < 0.001). Significant correlations were found between all posttraumatic stress disorder symptoms and executive function. Conclusions These findings suggest that individuals with cancer-related posttraumatic stress disorder exhibit more severe impairment in executive function than healthy controls do.
Fungal dysbiosis in cirrhosis

Objective Cirrhotics have a high rate of infections, which are increasingly fungal or culture-negative in nature. While infected cirrhotics have bacterial dysbiosis, the role of fungi is unclear. We aimed to evaluate gut bacterial and fungal dysbiosis in cross-sectional and longitudinal analyses of outpatient and inpatient cirrhotics and prediction of hospitalisations. Methods Cross-sectional: Age-matched controls, outpatients (with/without antibiotics) and hospitalised uninfected, culture-negative and culture-positive cirrhotics were included and followed for 90 days. Longitudinal: Three studies were conducted: (1) cirrhotics followed over 6 months, (2) outpatient cirrhotics administered antibiotics per standard of care for 5 days and (3) cirrhotics and controls administered omeprazole over 14 days. In all studies, stool bacterial/fungal profiles were analysed. Results Cross-sectional: In 143 cirrhotics and 26 controls, bacterial and fungal diversities were significantly linked. Outpatients on antibiotics and patients with culture-positive infections had the lowest diversities. Bacterial and fungal correlations were complex in uninfected, outpatient and control groups but were markedly skewed in infected patients. 21% were admitted on 90-day follow-up. A lower Bacteroidetes/Ascomycota ratio was associated with lower hospitalisations. Longitudinal: Fungal and bacterial profiles were stable on follow-up (5 days and 6 months). After antibiotics, a significantly reduced bacterial and fungal diversity, higher Candida and lower autochthonous bacterial relative abundance were seen. After omeprazole, changes in bacterial diversity and composition were seen but fungal metrics remained stable. Conclusion There is a significant fungal dysbiosis in cirrhosis, which changes differentially with antibiotics and proton pump inhibitor use, but is otherwise stable over time. A combined bacterial–fungal dysbiosis metric, Bacteroidetes/Ascomycota ratio, can independently predict 90-day hospitalisations in patients with cirrhosis. Clinical trial number NCT01458990.
Air Reflux and Other Sequelae Following Endoscopic Dacryocystorhinostomy

Purpose: To assess postoperative sequelae of endoscopic dacryocystorhinostomy (endoDCR), including rates of air reflux and other otolaryngologic sequelae. Methods: Patients who underwent endoDCR over a 5-year period were included in a follow-up questionnaire regarding side effects after surgery. The questionnaire included questions regarding tearing, air reflux, and nasal symptoms. Results: Results were obtained on 82 patients (101 endoDCRs). Most patients were women (70.7%) and white (85.4%). The mean postoperative period was 39.7 months (range 8–66 months). The most common sequela was air reflux from the puncta (46 cases, 45.5%). Of the 82 patients, 58.7% experienced symptoms only “rarely,” while 18.5% had symptoms daily. Air reflux was most commonly associated with nose blowing (73.9%). Success of endoDCR correlated with presence of air reflux (p = 0.0044). All patients with air reflux preferred having air reflux to epiphora. Epistaxis was present in 8 cases (7.9%) and nasal congestion in 21.8% of the cases. Conclusions: Treatment for epiphora with endoDCR results in air reflux in almost half of patients, which is minimally bothersome to patients. The presence of air reflux highly correlates with resolution of epiphora and has a similar incidence in external and endoDCRs.