Miracle-dz/UniFAR-FTUs huggingface dataset:
Outcomes of Lecture and Discussion Procedures in Three College Courses

THE INVESTIGATION here reported has sought to measure and contrast some out comes of lecture and discussion methods in col lege teaching. Since the cultivation of emotional and social values as well as of intellectual val ues has come to be included among the import ant objectives of the schools, the present study has sought to assess these outcomes as well as the intellectual outcomes of the two methods.
Effects of Lean Six Sigma application in healthcare services: a literature review

Abstract The healthcare organization is the place where defects and mistakes cannot be tolerated. A simple mistake can cost a human life so defects or mistakes must be eliminated in healthcare service processes. A Lean Six Sigma (LSS) approach is the best option in a healthcare environment for dealing with a critical patient. The LSS methodology optimizes the average reduction of a desired process. The expected results can be reductions in several aspects of healthcare such as patient waiting time in emergency departments, lost charges for billing in patient financial services, delinquent medical records, diagnostic result turnaround times, accounts receivable days, patients’ length of stay, or medication errors. This paper mainly discusses the effects of the LSS approach in different hospitals around the world according to the literature review. This review also discusses the relationship between LSS as well as their impacts on healthcare services based on literature review.
Periodontal Microbiota and Carotid Intima-Media Thickness: The Oral Infections and Vascular Disease Epidemiology Study (INVEST)

Background—Chronic infections, including periodontal infections, may predispose to cardiovascular disease. We investigated the relationship between periodontal microbiota and subclinical atherosclerosis. Methods and Results—Of 1056 persons (age 69±9 years) with no history of stroke or myocardial infarction enrolled in the Oral Infections and Vascular Disease Epidemiology Study (INVEST), we analyzed 657 dentate subjects. Among these subjects, 4561 subgingival plaque samples were collected (average of 7 samples/subject) and quantitatively assessed for 11 known periodontal bacteria by DNA-DNA checkerboard hybridization. Extensive in-person cardiovascular risk factor measurements, a carotid scan with high-resolution B-mode ultrasound, white blood cell count, and C-reactive protein values were obtained. In 3 separate analyses, mean carotid artery intima-media thickness (IMT) was regressed on tertiles of (1) burden of all bacteria assessed, (2) burden of bacteria causative of periodontal disease (etiologic bacterial burden), and (3) the relative predominance of causative/over other bacteria in the subgingival plaque. All analyses were adjusted for age, race/ethnicity, gender, education, body mass index, smoking, diabetes, systolic blood pressure, and LDL and HDL cholesterol. Overall periodontal bacterial burden was related to carotid IMT. This relationship was specific to causative bacterial burden and the dominance of etiologic bacteria in the observed microbiological niche. Adjusted mean IMT values across tertiles of etiologic bacterial dominance were 0.84, 0.85, and 0.88 (P=0.002). Similarly, white blood cell values increased across tertiles of etiologic bacterial burden from 5.57 to 6.09 and 6.03 cells ×109/L (P=0.01). C-reactive protein values were unrelated to periodontal microbial status (P=0.82). Conclusions—Our data provide evidence of a direct relationship between periodontal microbiology and subclinical atherosclerosis. This relationship exists independent of C-reactive protein.
Distribution of fluorescently labeled tubulin injected into sand dollar eggs from fertilization through cleavage

Porcine brain tubulin labeled with fluorescein isothiocyanate (FITC) was able to polymerize by itself and co-polymerize with tubulin purified from starfish sperm flagella. When we injected the FITC- labeled tubulin into unfertilized eggs of the sand dollar, Clypeaster japonicus, and the eggs were then fertilized, the labeled tubulin was incorporated into the sperm aster. When injected into fertilized eggs at streak stage, the tubulin was quickly incorporated into each central region of growing asters. It was clearly visualized that the labeled tubulin, upon reaching metaphase, accumulated in the mitotic apparatus and later disappeared over the cytoplasm during interphase. The accumulation of the fluorescence in the mitotic apparatus was observed repeatedly at successive cleavage. After lysis of the fertilized eggs with a microtubule-stabilizing solution, fluorescent fibrous structures around the nucleus and those of the sperm aster and the mitotic apparatus were preserved and coincided with the fibrous structures observed by polarization and differential interference microscopy. We found the FITC-labeled tubulin to be incorporated into the entire mitotic apparatus within 20-30 s when injected into the eggs at metaphase or anaphase. This rapid incorporation of the labeled tubulin into the mitotic apparatus suggests that the equilibrium between mitotic microtubules and tubulin is attained very rapidly in the living eggs. Axonemal tubulin purified from starfish sperm flagella and labeled with FITC was also incorporated into microtubular structures in the same fashion as the FITC-labeled brain tubulin. These results suggest that even FITC-labeled heterogeneous tubulins undergo spatial and stage-specific regulation of assembly-disassembly in the same manner as does sand dollar egg tubulin.
Developing Monitoring Techniques for the Invasive Goldspotted Oak Borer (Coleoptera: Buprestidae) in California

ABSTRACT The goldspotted oak borer, Agrilus auroguttatus Schaeffer (Coleoptera: Buprestidae), is an invasive species that has colonized oak woodlands in southern California. To better define its seasonal flight activity, assist with forest and integrated pest management activities, and define the current distribution in California, an effective monitoring technique for A. auroguttatus is necessary. We assessed the efficacy of two colors of flight-intercept prism traps, the placement of these traps at three heights, and several commercially available lures [Manuka oil, Phoebe oil, and a green leaf volatile, (3Z)-hexenol] for monitoring the flight of adult A. auroguttatus. Landing rates and the densities of D-shaped emergence holes of A. auroguttatus adults were assessed on the lower stems of coast live oak, Quercus agrifolia Née, of varying size and crown health classes. Purple flight-intercept prism traps placed at heights of 3 m and 4.5 m caught significantly more female A. auroguttatus than green prism traps. In one experiment, males also responded at a significantly higher level to purple than to green prism traps placed at 3 m height. The addition of commercially available lures significantly enhanced male, but not female, A. auroguttatus trap catch when compared with unbaited control traps. There were no differences among male flight responses to the three lures. A. auroguttatus landing rates and emergence hole densities were significantly greater on the largest-diameter trees (>76.2 cm diameter at breast height) and on trees with severe crown thinning or complete crown collapse. The annual increment in emergence hole densities was also significantly greater on trees with severe crown thinning or complete crown collapse. In three trapping studies over multiple years in southern California, the adult flight period began as early as mid-May, peaked in mid-June to early July, and ended in early- to mid-September. To demonstrate the efficacy of the detection method for A. auroguttatus (unbaited purple traps at 3 m height), a delimitation survey conducted from 2009 to 2012 confirmed that the species was only present in San Diego Co., but that the distribution was expanding northward.
Empirical Implications for the Training and Professional Development of Community College Counselors

Counselor education programs, which represent the major training environment for community college counselors, are currently identifying training needs to effectively prepare mental health counselors (Lewis & Lewis, 1981; Nejedlo, Arredondo & Benjamin, 1985; West, Hosie & Mackey, 1988). This is also true of school counseling programs (Carey, Reinat & Fontes, 1990) and student personnel affairs programs (Council for Accreditation of Counseling and Related Educational Programs, 1988). However, community college counselor training may be neglected in these programs. Only certain aspects of mental health, school counseling and college student services personnel training are appropriate for community college counselors. To many in the counselor education field, community college counselors are considered student personnel workers. Yet student personnel training is typically oriented toward four-year colleges and universities, and emphasizes specialized student services. Community college student services typically operate with combined services. For example, most community colleges offer counseling, career development, academic advising and orientation under the service area of counseling. These services are segmented into four separate units at most fouryear colleges and universities. Other counselor educators view community colleges as extensions of high schools, so school counseling training is deemed appropriate. The drawback to this perception is that the community college population is drastically different from the high school population. The typical community college student today is female, divorced, has children and is in her late 20s (Cohen & Brawer, 1989). Clearly, the developmental needs of community college students are quite different than those of high school students. Many counselor education programs do not reflect the similarities in duties between a mental health/community counselor and a community college coun-
An investigation into the differential profile of predictors of objective and subjective career success

This research examined the different profile of individual, opportunity structure, and career strategy variables related to both objective (salary) and subjective (self‐perceived) career success. Questionnaire data were obtained from a stratified sample of 723 full‐time employees at several higher education institutions in the north of England. Controlling for age, tenure, gender, and occupation, a different profile of factors predicted objective and subjective career success. The highest objective career success was reported by employees with a high level of education, who worked in larger organizations with well‐structured progression ladders and invested considerable effort in their work role. In contrast, the highest subjective career success was reported by employees who were high on work centrality, who worked in organizations with well‐structured progression ladders and employment security, and who networked frequently yet reported a lack of ambition. The theoretical and practical implications of these findings are discussed, together with avenues for further research.
Mutations in HSPB8 causing a new phenotype of distal myopathy and motor neuropathy

Objective: To report novel disease and pathology due to HSPB8 mutations in 2 families with autosomal dominant distal neuromuscular disease showing both myofibrillar and rimmed vacuolar myopathy together with neurogenic changes. Methods: We performed whole-exome sequencing (WES) in tandem with linkage analysis and candidate gene approach as well as targeted next-generation sequencing (tNGS) to identify causative mutations in 2 families with dominant rimmed vacuolar myopathy and a motor neuropathy. Pathogenic variants and familial segregation were confirmed using Sanger sequencing. Results: WES and tNGS identified a heterozygous change in HSPB8 in both families: c.421A > G p.K141E in family 1 and c.151insC p.P173SfsX43 in family 2. Affected patients had a distal myopathy that showed myofibrillar aggregates and rimmed vacuoles combined with a clear neurogenic component both on biopsy and neurophysiologic studies. MRI of lower limb muscles demonstrated diffuse tissue changes early in the disease stage progressing later to fatty replacement typical of a myopathy. Conclusion: We expand the understanding of disease mechanisms, tissue involvement, and phenotypic outcome of HSPB8 mutations. HSPB8 is part of the chaperone-assisted selective autophagy (CASA) complex previously only associated with Charcot-Marie-Tooth type 2L (OMIM 60673) and distal hereditary motor neuronopathy type IIa. However, we now demonstrate that patients can develop a myopathy with histologic features of myofibrillar myopathy with aggregates and rimmed vacuoles, similar to the pathology in myopathies due to gene defects in other compounds of the CASA complex such as BAG3 and DNAJB6 after developing the early neurogenic effects.
A Schools-University Research Partnership: understandings, models and complexities

Abstract This article is based on the authors' experiences and understandings of a schools-university partnership between eight secondary schools and the Faculty of Education, University of Cambridge. The focus of the partnership is the development of useful practice-based research within, across and between the schools and the university. The authors explore the different views of research held by partners and examine the relationship between those understandings and conceptions of partnership. In doing so they identify some key conditions and actions necessary for useful practice-based research to take place. The complex nature of such partnerships is addressed throughout.
Are Neurons Adapted for Specific Computations? Examples from Temporal Coding in the Auditory System

Are neurons adapted for specific computations? Evolution has led to the appearance of specialized neurons, such as the neurons in the auditory system that encode temporal informationwith great precision (Trussell 1997; Oertel 1999). Nevertheless, it is not clear whether all neurons are adapted for particular computations or even whether specialized computational units are desirable under all circumstances. Some neurons may have more general responses. Other neuron types change their responses under the action of somemodulator, but these might be regarded as being adapted for several computations, rather than for some general input-output function (see Golowasch et al. 1999; Stemmler and Koch 1999; Turrigiano, Abbot, and Marder 1994). It is important to understand the functions of single neurons. Johnston et al (1996) wrote, ‘‘Before one can hope to understand systems of neurons fully, onemust be able to describe the function of the basic unit of the nervous system, that is, the singleneuronand its associated dendritic tree. ’’ Tomake the case that neurons may be adapted for particular tasks, we will use the example of temporal coding cells in the vertebrate auditory systembecause their function iswell known. This allows us to tie physiological and morphological observations to function.
The impact of placing pupils with special educational needs in mainstream schools on the achievement of their peers

Background Over the past 20 years or so policy and practice on the education of children with special educational needs (SEN) has been aimed at placing increasing numbers of children in a mainstream school environment. Although this policy has been supported in principle by many teachers, parents and local authority officers, there has been much less agreement about whether this principle can be realized in practice, and even if it can, about what the impacts might be on the achievements of pupils with SEN in mainstream schools and, in particular, on their peers. Purpose This paper discusses the key findings from a systematic review of the literature carried out by the Inclusion Review Group, on behalf of the Evidence for Policy and Practice Information (EPPI)-Centre, the purpose of which was to review research evidence on whether the placement of pupils with special educational needs (SEN) within mainstream schools has an impact on academic and social outcomes for pupils without SEN. Design and methods The methodology followed the procedures adopted by the EPPI-Centre. Having agreed on the inclusion and exclusion criteria for studies that could be included in the review, an initial pool of 7137 papers were identified through electronic databases. After having screened all their titles and/or abstracts and having marked out possible papers to be included in the review, 119 paper copies were obtained—all of which were read by one or more of the authors of this paper. This led to a further reduction to 26 studies that were subjected to the EPPI data extraction process and synthesis. Conclusions Overall, the findings suggest that there are no adverse effects on pupils without SEN of including pupils with special needs in mainstream schools, with 81% of the outcomes reporting positive or neutral effects. Despite concerns about the quality of some of the studies that were reviewed and the fact that the great majority were carried out in the USA, these findings should bring some comfort to headteachers, parents and local authority officers around the world at a time when concerns have been raised about the problems that schools face in responding to the twin agenda of becoming more inclusive and, at the same time, raising the achievements of all their pupils.
The constitutive element of probabilistic agency in risk: a semantic analysis of risk, danger, chance, and hazard

Defining central concepts with accuracy is crucial to any scientific discipline. A recent debate over risk definitions in this journal illustrates the far reaching consequences of divergent definitions. Aven and Renn define risk as a social construct while Rosa defines risk as an ontological fact. Both claim that their definition reflects the common usage of the word risk. Through a semantic analysis this paper points to a constitutive element of what is termed probabilistic agency in the risk concept. In this respect, risk is distinct from danger, and because Rosa’s main argument is based on the apparent synonymy between risk and danger, the premises for his risk ontology are not valid. The paper furthermore argues that Aven and Renn’s attempt to bridge between epistemology and ontology is based on a distinction between a conceptual level of risk and its practical application which is impossible to uphold if a risk definition is to be in accordance with the ordinary usage of the word. The paper concludes by arguing that risks are only real within a subjective ontology.
LBD18/ASL20 Regulates Lateral Root Formation in Combination with LBD16/ASL18 Downstream of ARF7 and ARF19 in Arabidopsis1[C][W][OA]

The LATERAL ORGAN BOUNDARIES DOMAIN/ASYMMETRIC LEAVES2-LIKE (LBD/ASL) genes encode proteins harboring a conserved amino acid domain, referred to as the LOB (for lateral organ boundaries) domain. While recent studies have revealed developmental functions of some LBD genes in Arabidopsis (Arabidopsis thaliana) and in crop plants, the biological functions of many other LBD genes remain to be determined. In this study, we have demonstrated that the lbd18 mutant evidenced a reduced number of lateral roots and that lbd16 lbd18 double mutants exhibited a dramatic reduction in the number of lateral roots compared with lbd16 or lbd18. Consistent with this observation, significant β-glucuronidase (GUS) expression in ProLBD18:GUS seedlings was detected in lateral root primordia as well as in the emerged lateral roots. Whereas the numbers of primordia of lbd16, lbd18, and lbd16 lbd18 mutants were similar to those observed in the wild type, the numbers of emerged lateral roots of lbd16 and lbd18 single mutants were reduced significantly. lbd16 lbd18 double mutants exhibited additively reduced numbers of emerged lateral roots compared with single mutants. This finding indicates that LBD16 and LBD18 may function in the initiation and emergence of lateral root formation via a different pathway. LBD18 was shown to be localized into the nucleus. We determined whether LBD18 functions in the nucleus using a steroid regulator-inducible system in which the nuclear translocation of LBD18 can be regulated by dexamethasone in the wild-type, lbd18, and lbd16 lbd18 backgrounds. Whereas LBD18 overexpression in the wild-type background induced lateral root formation to some degree, other lines manifested the growth-inhibition phenotype. However, LBD18 overexpression rescued lateral root formation in lbd18 and lbd16 lbd18 mutants without inducing any other phenotypes. Furthermore, we demonstrated that LBD18 overexpression can stimulate lateral root formation in auxin response factor7/19 (arf7 arf19) mutants with blocked lateral root formation. Taken together, our results suggest that LBD18 functions in the initiation and emergence of lateral roots, in conjunction with LBD16, downstream of ARF7 and ARF19.
Learner Code-Switching in the Content-Based Foreign Language Classroom

Using a framework based on conversation analysis (Auer, 1984, 1995, 1998), this article presents an analysis of learner code-switching between L1 and L2 in an advanced foreign language (FL) classroom. It was found that students code-switch not only as a fallback method when their knowledge of the L2 fails them, or for other participant-related functions, but also for discourse-related functions that contexualize the interactional meaning of their utterances. These uses strikingly resemble code-switching patterns in non-classroom bilingual settings and show that language learners are able to conceptualize the classroom as a bilingual space. Learners orient to the classroom as a community of practice (Wenger, 1998) through their code-switching patterns as manifestations of a shared understanding about their actions and about themselves as members of that community.
The Relationship between ITCZ Location and Cross-Equatorial Atmospheric Heat Transport: From the Seasonal Cycle to the Last Glacial Maximum

The authors quantify the relationship between the location of the intertropical convergence zone (ITCZ) and the atmospheric heat transport across the equator (AHTEQ) in climate models and in observations. The observed zonal mean ITCZ location varies from 5.38S in the boreal winter to 7.28N in the boreal summer with an annual mean position of 1.658N while the AHTEQvaries from 2.1 PW northward in the boreal winter to 2.3 PW southward in the boreal summer with an annual mean of 0.1 PW southward. Seasonal variations in the ITCZ location and AHTEQ are highly anticorrelated in the observations and in a suite of state-of-the-art coupledclimatemodelswithregressioncoefficientsof22.78and22. 48PW 21 respectively.Itisalsofoundthat seasonal variations in ITCZ location and AHTEQ are well correlated in a suite of slab ocean aquaplanet simulations with varying ocean mixed layer depths. However, the regression coefficient between ITCZ location and AHTEQ decreases with decreasing mixed layer depth as a consequence of the asymmetry that develops between the winter and summer Hadley cells as the ITCZ moves farther off the equator. The authors go on to analyze the annual mean change in ITCZ location and AHTEQ in an ensemble of climate perturbation experiments including the response to CO2 doubling, simulations of the Last Glacial Maximum, and simulations of the mid-Holocene. The shift in the annual average ITCZ location is also strongly anticorrelated with the change in annual mean AHTEQ with a regression coefficient of 23.28 PW 21 , similar to that found over the seasonal cycle.