Miracle-dz/UniFAR-FTUs huggingface dataset:
What Are the Hot R Coronae Borealis Stars?

We investigate the evolutionary status of four stars: V348 Sgr, DY Cen, and MV Sgr in the Galaxy and HV 2671 in the LMC. These stars have in common random deep declines in visual brightness, which are characteristic of R Coronae Borealis (RCB) stars. RCB stars are typically cool hydrogen-deficient supergiants. The four stars studied in this paper are hotter (Teff = 15–20 kK) than the majority of RCB stars (Teff = 5000–7000 K). Although these are commonly grouped together as the hot RCB stars they do not necessarily share a common evolutionary history. We present new observational data and an extensive collection of archival and previously published data that is reassessed to ensure internal consistency. We find temporal variations of various properties on different timescales that will eventually help us to uncover the evolutionary history of these objects. DY Cen and MV Sgr have typical RCB helium abundances, which exclude any currently known post–asymptotic giant branch (post-AGB) evolutionary models. Moreover, their carbon and nitrogen abundances present us with further problems for their interpretation. V348 Sgr and HV 2671 are in general agreement with a born-again post-AGB evolution, and their abundances are similar to Wolf-Rayet central stars of planetary nebulae (PNs). The three Galactic stars in the sample have circumstellar nebulae, which produce forbidden line radiation (for HV 2671 we have no information). V348 Sgr and DY Cen have low-density, low-expansion velocity nebulae (resolved in the case of V348 Sgr), while MV Sgr has a higher density, higher expansion velocity nebula. All three stars, on the other hand, have split emission lines, which indicate the presence of an equatorial bulge but not of a Keplerian disk. In addition, the historical light curves for the three Galactic hot RCB stars show evidence for a significant fading in their maximum-light brightnesses of ∼1 mag over the last 70 yr. From this we deduce that their effective temperatures increased by a few thousand degrees. If V348 Sgr is a born-again star, as we presume, this means that the star is returning from the born-again AGB phase to the phase of a central star of PN. Spectroscopically, no dramatic change is observed over the last 50 years for V348 Sgr and MV Sgr. However, there is some evidence that the winds of V348 Sgr and DY Cen have increased in strength in the last decade. HV 2671, located in the LMC, has not been analyzed in detail but at 5 Å resolution is almost identical to V348 Sgr. Through the bolometric correction derived for V348 Sgr and the known distance, we can estimate the absolute V magnitude of HV 2671 (MV = -3.0 mag) and its bolometric luminosity (∼6000 L⊙).
Letting Ants Labeling Point Features

This paper describes an ant colony system (ACS) for labeling point features. A preprocessing step reduces the search space in a safe way. The ACS applies local improvement and masking, a technique that focuses the optimization on criti- cal regions. Empirical results indicate that the ACS reliably iden- tifies high-quality solutions which are in many cases better than those of a state-of-the-art genetic algorithm for point feature la- beling.
Synaptic Remodeling of Entorhinal Input Contributes to an Aberrant Hippocampal Network in Temporal Lobe Epilepsy

Abstract The hippocampus is reciprocally connected with the entorhinal cortex. Although several studies emphasized a role for the entorhinal cortex in mesial temporal lobe epilepsy (MTLE), it remains uncertain whether its synaptic connections with the hippocampus are altered. To address this question, we traced hippocampo‐entorhinal and entorhino‐hippocampal projections, assessed their connectivity with the respective target cells and examined functional alterations in a mouse model for MTLE. We show that hippocampal afferents to the dorsal entorhinal cortex are lost in the epileptic hippocampus. Conversely, entorhino‐dentate projections via the medial perforant path (MPP) are preserved, but appear substantially altered on the synaptic level. Confocal imaging and 3D‐reconstruction revealed that new putative contacts are established between MPP fibers and dentate granule cells (DGCs). Immunohistochemical identification of pre‐ and postsynaptic elements indicated that these contacts are functionally mature synapses. On the ultrastructural level, pre‐ and postsynaptic compartments of MPP synapses were strongly enlarged. The length and complexity of postsynaptic densities were also increased pointing to long‐term potentiation‐related morphogenesis. Finally, whole‐cell recordings of DGCs revealed an enhancement of evoked excitatory postsynaptic currents. In conclusion, the synaptic rearrangement of excitatory inputs to DGCs from the medial entorhinal cortex may contribute to the epileptogenic circuitry in MTLE.
Evolutionary algorithms for the self-organized evolution of networks

While the evolution of biological networks can be modeled sensefully as a series of mutation and selection, evolution of other networks such as the social network in a city or the network of streets in a country is not determined by selection since there is no alternative network with which these singular networks have to compete. Nonetheless, these singular networks do evolve due to dynamic changes of vertices and edges. In this article we present a formal, analyzable framework for the evolution of singular networks. We show that the careful design of adaptation rules can lead to the emergence of network topologies with satisfying performance in polynomial time while other adaptation rules yield exponential runtime. We further show by example how the framework could be applied to some ad-hoc communication scenarios.
Patient-expectancy and symptom reduction.

In recent years, psychotherapy has gained widespread acceptance as an effective method of treatment for patients suffering from mental illness. At the turn of the century there were a handful of psychotherapists in this country. Today they number many thousand. Lay acceptance of this form of treatment has been so widespread that the number of patients seeking psychiatric aid has outstripped the available number of psychotherapists. 12 Our knowledge of what elements in psychotherapy make it an effective tool in the treatment of psychological disorders, however, has not increased significantly. No research has, of yet, proved that psychotherapy is more effective than any other kind of help-giving. 9,10 It is apparent that there is great need to subject the psychotherapeutic situation to investigation, in order to increase our understanding of how psychotherapy works. Two experimental approaches have been most commonly pursued in the investigation
A Systematic Review of the Huntington Disease-Like 2 Phenotype.

BACKGROUND Huntington Disease-like 2 (HDL2) is a neurodegenerative disorder similar to Huntington Disease (HD) in its clinical phenotype, genetic characteristics, neuropathology and longitudinal progression. Proposed specific differences include an exclusive African ancestry, lack of eye movement abnormalities, increased Parkinsonism, and acanthocytes in HDL2. OBJECTIVE The objective was to determine the similarities and differences between HD and HDL2 by establishing the clinical phenotype of HDL2 with the published cases. METHODS A literature review of all clinically described cases of HDL2 until the end of 2016 was performed and a descriptive analysis was carried out. RESULTS Sixty-nine new cases were described between 2001 and 2016. All cases had likely African ancestry, and most were found in South Africa and the USA. Many features were found to be similar to HD, including a strong negative correlation between repeat length and age of onset. Chorea was noted in 48/57 cases (84%). Dementia was reported in 74% patients, and Parkinsonism in 37%. Psychiatric features were reported in 44 out of 47 cases. Patients with chorea had lower expanded repeat lengths compared to patients without chorea. Eye movements were described in 19 cases, 8 were abnormal. Acanthocytes were detected in 4 of the 13 patients tested. Nineteen out of 20 MRIs were reported as abnormal with findings similar to HD. CONCLUSION This review clarifies some aspects of the HDL2 phenotype and highlights others which require further investigation. Features that are unique to HDL2 have been documented in a minority of subjects and require prospective validation.
Support for Teaching Formal Methods Report of the ITiCSE 2000 Working Group on Formal Methods Education

This report describes a growth path for the area referred to as formal methods within the computing education community. We define the term formal methods and situate it within our field by highlighting its role in Computing Curricula 1991, Computing Curricula 2001, and the SoftWare Engineering Body Of Knowledge (SWEBOK). The working group proposes an enhancement to an existing web resource, which is a rich collection of materials and links related to formal methods. The new resource is designed to provide a bridge between the general computing education community and the formal methods community. The goal is to allow the latter to provide useful support for the former for the ultimate benefit of all of our students. Eventually, the working group aspires to see the concepts of formal methods integrated seamlessly into the computing curriculum so that it is not necessary to separate them in our discussions.
Intracellular Signaling and Desmoglein 2 Shedding Triggered by Human Adenoviruses Ad3, Ad14, and Ad14P1

ABSTRACT We recently discovered that desmoglein 2 (DSG2) is a receptor for human adenovirus species B serotypes Ad3, Ad7, Ad11, and Ad14. Ad3 is considered to be a widely distributed human pathogen. Ad3 binding to DSG2 triggers the transient opening of epithelial junctions. Here, we further delineate the mechanism that leads to DSG2-mediated epithelial junction opening in cells exposed to Ad3 and recombinant Ad3 fiber proteins. We identified an Ad3 fiber knob-dependent pathway that involves the phosphorylation of mitogen-activated protein (MAP) kinases triggering the activation of the matrix-metalloproteinase ADAM17. ADAM17, in turn, cleaves the extracellular domain of DSG2 that links epithelial cells together. The shed DSG2 domain can be detected in cell culture supernatant and also in serum of mice with established human xenograft tumors. We then extended our studies to Ad14 and Ad14P1. Ad14 is an important research and clinical object because of the recent appearance of a new, more pathogenic strain (Ad14P1). In a human epithelial cancer xenograft model, Ad14P1 showed more efficient viral spread and oncolysis than Ad14. Here, we tested the hypothesis that a mutation in the Ad14P1 fiber knob could account for the differences between the two strains. While our X-ray crystallography studies suggested an altered three-dimensional (3D) structure of the Ad14P1 fiber knob in the F-G loop region, this did not significantly change the fiber knob affinity to DSG2 or the intracellular signaling and DSG2 shedding in epithelial cancer cells. IMPORTANCE A number of widely distributed adenoviruses use the epithelial junction protein DSG2 as a receptor for infection and lateral spread. Interaction with DSG2 allows the virus not only to enter cells but also to open epithelial junctions which form a physical barrier to virus spread. Our study elucidates the mechanism beyond virus-triggered junction opening with a focus on adenovirus serotype 3. Ad3 binds to DSG2 with its fiber knob domain and triggers intracellular signaling that culminates in the cleavage of the extracellular domain of DSG2, thereby disrupting DSG2 homodimers between epithelial cells. We confirmed this pathway with a second DSG2-interacting serotype, Ad14, and its recently emerged strain Ad14P1. These new insights in basic adenovirus biology can be employed to develop novel drugs to treat adenovirus infection as well as be used as tools for gene delivery into epithelial tissues or epithelial tumors.
Five-Year Survival after First-Ever Ischaemic Stroke Is Worse in Total Anterior Circulation Infarcts: The SINPAC Cohort

Background: Few studies have addressed predictors of long-term mortality after first-ever ischaemic stroke. Methods: We prospectively collected data on 361 consecutive patients admitted to 18 neurology departments in Italy for a first-ever ischaemic stroke in 1999, categorized according to the Oxfordshire Community Stroke Project (OCSP) classification. Age, gender, risk factors, previous vascular disease, in-hospital complications, stroke severity, functional status, therapy and living place at admission, discharge and after 6 months were recorded. Follow-up was available for 97% patients at 5 years. Results: Survival probability was 91% (95% CI = 88–94) at 1 month, 84% (80–88) at 6 months and 64% (58–69) at 5 years. Mortality was higher for the TACI (total anterior circulation infarct) group compared to the other categories (p < 0.0001). Hazard ratios for 5-year mortality in the final model were: 5.4 for age ≥65 years (p < 0.0001), 2.8 for TACI (p < 0.0001), 2.7 for previous vascular disease (p < 0.01) and 1.9 for cardio-embolic risk according to the TOAST risk stratification (p < 0.05). Conclusions: Our study extends the prognostic value of the OCSP classification to 5-year survival.
Follow-Up of 316 Molecularly Defined Pediatric Long-QT Syndrome Patients: Clinical Course, Treatments, and Side Effects

Background—Inherited long-QT syndrome (LQTS) is associated with risk of sudden death. We assessed the clinical course and the fulfillment of current treatment strategies in molecularly defined pediatric LQTS type 1 and (LQT1) and type 2 (LQT2) patients. Methods and Results—Follow-up data covering a mean of 12 years were collected for 316 genotyped LQT1 and LQT2 patients aged 0 to 18 years. No arrhythmic deaths occurred during the follow-up. Finnish KCNQ1 and KCNH2 founder mutations were associated with fewer cardiac events than other KCNQ1 and KCNH2 mutations (hazard ratio [HR], 0.33; P=0.03 and HR, 0.16; P=0.01, respectively). QTc interval ≥500 ms increased the risk of cardiac events compared with QTc <470 ms (HR, 3.32; P=0.001). Treatment with &bgr;-blocker medication was associated with reduced risk of first cardiac event (HR, 0.23; P=0.001). Noncompliant LQT2 patients were more often symptomatic than compliant LQT2 patients (18% and 0%, respectively; P=0.03). Treatment with implantable cardioverter defibrillator was rare (3%) and resulted in reinterventions in 44% of cases. Conclusions—Severe cardiac events are uncommon in molecularly defined and appropriately treated pediatric LQTS mutation carriers. &bgr;-Blocker medication reduces the risk of cardiac events and is generally well tolerated in this age group of LQTS patients.
Prophylactic and therapeutic efficacy of Australian‐registered insecticide formulations against Old World screwworm (Chrysomya bezziana) infestation

OBJECTIVE To determine the prophylactic and therapeutic efficacy of Australian-registered insecticide formulations against Old World screwworm (OWS) myiases for potential use in screwworm containment and eradication programs. METHODS The longevity of protection provided by six insecticidal formulations (subcutaneous ivermectin, doramectin and abamectin, a topically applied aqueous formulation of spinosad, ivermectin controlled-release capsule and a dicyclanil spray-on formulation) was tested using implants of 1st-instar OWS larvae on Javanese thin-tail sheep. Therapeutic efficacy of four formulations (topical ivermectin, chlorfenvinphos/cypermethrin mixture, aerosol spinosad formulation and a formulation containing propetamphos and eucalyptus oil) was tested against 2- and 4-day-old OWS strikes. RESULTS Both the ivermectin capsule and dicyclanil spray-on formulation gave 100% protection against screwworm implants for the full 12 weeks of the study. Ivermectin, doramectin and abamectin administered SC all gave 100% protection at 3 days post-treatment, but at 2 weeks the protection had become incomplete. Spinosad dipping did not give complete protection at any time. All four therapeutic treatments gave complete resolution of 2-day-old strikes and topical ivermectin, spinosad and chlorfenvinphos/cypermethrin, but not the propetamphos/eucalyptus oil formulation, gave complete resolution of all 4-day-old strikes. CONCLUSION Dicyclanil spray-on and ivermectin capsule formulations, both registered for use in sheep, but not for cattle or other livestock species, gave much longer protection against screwworm implants than the currently recommended SC ivermectin. Pre-emptive action to facilitate rapid deployment of these formulations in the event of a screwworm incursion is urgently needed.
Dynamic modelling of a single-walled carbon nanotube for nanoparticle delivery

In this paper, the dynamic behaviour of a single-walled carbon nanotube (SWCNT) for nanoparticle delivery is studied using non-local elasticity theory. The response of the delivery system depends on the time history and velocity of the moving nanoparticle. In addition, the interaction between the SWCNT and the moving nanoparticle, and the foundation of the SWCNT can also influence the dynamic behaviour of the system. The effects of foundation stiffness, confined stiffness, velocity ratio, non-local parameter and travel time on the behaviour are analysed using the Runge–Kutta method. The numerical solution is in agreement with the analytical result for the special case. The numerical analysis shows that increasing the non-local parameter, confined stiffness and foundation stiffness decreases the dynamic displacement of SWCNT. However, increasing the velocity ratio increases the maximum displacement.
Regulation of outer membrane protein synthesis in Escherichia coli K-12: deletion of ompC affects expression of the OmpF protein

A chromosomal deletion beginning at a Tn10 located ca. 8 kilobases upstream from the ompC structural gene and extending through the 2.6-kilobase HindIII fragment carrying the ompC was isolated. The 2.6-kilobase ompC fragment was cloned into lambda 540 to obtain phage lambda 540C1. When the deletion mutant was lysogenized with lambda 540C1, the resulting strain produced normal levels of OmpC protein, and expression of this protein was regulated by osmolarity, carbon source, and the lc gene of phage PA-2, indicating that the cloned fragment contained all of the information required for regulated expression of ompC. The strain carrying the deletion was partially constitutive for expression of OmpF protein, whereas the lambda 540C1 lysogen of this strain and other strains with mutations in ompC repressed OmpF synthesis under conditions which lead to high-level expression of OmpC protein. Strains which are diploid or triploid for ompC show strong inhibition of synthesis of OmpF protein. We conclude that a regulatory element located upstream from the ompC coding sequence inhibits translation of OmpF protein under conditions which favor OmpC expression. Since ompF is known to repress transcription of ompC, we propose that these two genes constitute a closed regulatory loop which acts to amplify regulatory signals which control expression of these proteins.
A General Model for the Origin of Allometric Scaling Laws in Biology

Allometric scaling relations, including the 3/4 power law for metabolic rates, are characteristic of all organisms and are here derived from a general model that describes how essential materials are transported through space-filling fractal networks of branching tubes. The model assumes that the energy dissipated is minimized and that the terminal tubes do not vary with body size. It provides a complete analysis of scaling relations for mammalian circulatory systems that are in agreement with data. More generally, the model predicts structural and functional properties of vertebrate cardiovascular and respiratory systems, plant vascular systems, insect tracheal tubes, and other distribution networks.
No evidence for reduced Simon cost in elderly bilinguals and bidialectals

We explored whether a bilingual advantage in executive control is associated with differences in cultural and ethnic background associated with the bilinguals' immigrant status, and whether dialect use in monolinguals can also incur such an advantage. Performance on the Simon task in older non-immigrant (Gaelic-English) and immigrant (Bengali, Gujarati, Hindi, Malay, Punjabi, Urdu-English) bilinguals was compared with three groups of older monolingual English speakers, who were either monodialectal users of the same English variety as the bilinguals or were bidialectal users of a local variety of Scots. Results showed no group differences in overall reaction times as well as in the Simon effect thus providing no evidence that an executive control advantage is related to differences in cultural and ethnic background as was found for immigrant compared to non-immigrant bilinguals, nor that executive control may be improved by use of dialect. We suggest the role of interactional contexts and bilingual literacy as potential explanations for inconsistent findings of a bilingual advantage in executive control.
Sitting-up vertigo and trunk retropulsion in patients with benign positional vertigo but without positional nystagmus

Background Presently, the unambiguous diagnosis of benign paroxysmal positioning vertigo (BPPV) requires the detection of positioning or positional nystagmus provoked by Dix–Hallpike (for vertical semicircular canals) or supine roll (for horizontal semicircular canals) manoeuvres, which indicates canalo- or cupolithiasis of affected semicircular canals. There are patients, however, in whom—despite typical complaints of BPPV—no positional nystagmus can be documented; this is called ‘subjective BPPV’ (sBPPV). These patients usually complain of short vertigo spells during and after sitting up, sometimes with abnormal retropulsion of the trunk. Aim In this study, the authors aimed to ascertain whether these patients in fact demonstrate abnormal sitting-up trunk oscillations when measured by posturography. Of 200 unselected patients with vertigo or dizziness, 43% had sBPPV with vertigo spells while sitting up, and 20% classical BPPV. Methods Posturographic recordings were performed in 20 patients with sBPPV and sitting-up vertigo. Results and discussion Seven of the 20 patients had trunk oscillations during the act of sitting up and for a short time immediately afterwards. Based on their findings, the authors propose a new type of BPPV, the so-called Type 2 BPPV (typical complaints of BPPV, no nystagmus in Dix–Hallpike positions but short vertigo spell while sitting up), which may be the result of chronic canalolithiasis within the short arm of a posterior canal. Furthermore, the authors suggest that Type 2 BPPV, which could be identical to sBPPV or constitute a major subgroup of it, occurs frequently among patients with vertigo. For therapy, the authors recommend repetitive sit-ups from the Dix–Hallpike positions to liberate the short arm of the posterior canal from canaloliths.