Miracle-dz/UniFAR-FTUs huggingface dataset:
Stimulation of the subthalamic nucleus in Parkinson’s disease: a 5 year follow up

Background: The short term benefits of bilateral stimulation of the subthalamic nucleus (STN) in patients with advanced levodopa responsive Parkinson’s disease (PD) are well documented, but long term benefits are still uncertain. Objectives: This study provides a 5 year follow up of PD patients treated with stimulation of the STN. Methods: Thirty seven consecutive patients with PD treated with bilateral STN stimulation were assessed prospectively 6, 24, and 60 months after neurosurgery. Parkinsonian motor disability was evaluated with and without levodopa treatment, with and without bilateral STN stimulation. Neuropsychological and mood assessments included the Mattis Dementia Rating Scale, the frontal score, and the Montgomery-Asberg Depression Rating Scale (MADRS). Results: No severe peri- or immediate postoperative side effects were observed. Six patients died and one was lost to follow up. Five years after neurosurgery: (i) activity of daily living (Unified Parkinson Disease Rating Scale (UPDRS) II) was improved by stimulation of the STN by 40% (“off” drug) and 60% (“on” drug); (ii) parkinsonian motor disability (UPDRS III) was improved by 54% (“off” drug) and 73% (“on” drug); (iii) the severity of levodopa related motor complications was decreased by 67% and the levodopa daily doses were reduced by 58%. The MADRS was unchanged, but cognitive performance declined significantly. Persisting adverse effects included eyelid opening apraxia, weight gain, addiction to levodopa treatment, hypomania and disinhibition, depression, dysarthria, dyskinesias, and apathy. Conclusions: Despite moderate motor and cognitive decline, probably due to disease progression, the marked improvement in motor function observed postoperatively was sustained 5 years after neurosurgery.
Neem leaves extract based seaweed bio-degradable composite films with excellent antimicrobial activity for sustainable packaging material

Seaweed-based biodegradable films were studied with incorporation of different concentrations of neem (Azadirachta indica) leaf extract. The films were fabricated via a hot casting method and were subjected to physical, mechanical, and morphological examinations to investigate the effect of the neem extract reinforcement in the edible film. There was moderate improvement in the tensile strength, contact angle values, and elongation at break values, while the water vapour permeability was reduced with the addition of neem leaves extract beyond 5 w/w %. Analysis of the morphology of the fabricated films confirmed that there was good dispersion of the neem leaves extract in the seaweed matrix films, which resulted in the enhanced mechanical strength of the fabricated films. Moreover, the fabricated composite films showed excellent antimicrobial activity towards both Gram-positive bacterium subclasses (coccus and bacillus), which is highly desirable for the packaging material in the current scenario. So far, this is the first report on neem leave based seaweed films with enhanced antimicrobial activity, which makes them suitable for sustainable packaging application. The experiments showed that the seaweed-based film incorporated with neem leaves extract has potential application as an active packaging material due to its enhanced mechanical properties and antimicrobial activity.
Evolution of small prokaryotic genomes

As revealed by genome sequencing, the biology of prokaryotes with reduced genomes is strikingly diverse. These include free-living prokaryotes with ∼800 genes as well as endosymbiotic bacteria with as few as ∼140 genes. Comparative genomics is revealing the evolutionary mechanisms that led to these small genomes. In the case of free-living prokaryotes, natural selection directly favored genome reduction, while in the case of endosymbiotic prokaryotes neutral processes played a more prominent role. However, new experimental data suggest that selective processes may be at operation as well for endosymbiotic prokaryotes at least during the first stages of genome reduction. Endosymbiotic prokaryotes have evolved diverse strategies for living with reduced gene sets inside a host-defined medium. These include utilization of host-encoded functions (some of them coded by genes acquired by gene transfer from the endosymbiont and/or other bacteria); metabolic complementation between co-symbionts; and forming consortiums with other bacteria within the host. Recent genome sequencing projects of intracellular mutualistic bacteria showed that previously believed universal evolutionary trends like reduced G+C content and conservation of genome synteny are not always present in highly reduced genomes. Finally, the simplified molecular machinery of some of these organisms with small genomes may be used to aid in the design of artificial minimal cells. Here we review recent genomic discoveries of the biology of prokaryotes endowed with small gene sets and discuss the evolutionary mechanisms that have been proposed to explain their peculiar nature.
Tribology Study of High-Technological Composite Coatings Applied Using High Velocity Oxy-Fuel

In the work are studied the differential parameters of wear and wear resistance of high-tech composite coatings of powder superalloys with nickel matrix, WC-12Co and mixed compositions. Coatings were created and applied to a substrate of steel with a different flame velocity - 700 m/s and 1000 m/s without preheating the substrate and with preheating the substrate to 650° C. The wear is carried out with a "thumb-disk" tribotester under dry surface friction with fixed black corundum abrasive particles. Comparative results were obtained for the microstructure and texture of the pre- and post- friction coating, the porosity, roughness, hardness, the dependence of mass wear, the speed and wear intensity and the wear resistance of the coatings on the number of friction cycles. Influence of the flame rate and substrate temperature on wear resistance and differential wear parameters has been determined.
Stock Index Futures Trading and Volatility in International Equity Markets

This article examines stock market volatility before and after the introduction of equity‐index futures trading in twenty‐five countries, using various models that account for asynchronous data, conditional heteroskedasticity, asymmetric volatility responses, and the joint dynamics of each country's index with the world‐market portfolio. We found that futures trading is related to an increase in conditional volatility in the United States and Japan, but in nearly every other country, we found either no significant effect or a volatility‐dampening effect. This result appears to be robust to model specification and is corroborated by further analysis of the relationship between volatility, trading volume, and open interest in stock futures. An increase in conditional covariance between country‐specific and world returns at the time of futures listing is also documented. © 2000 John Wiley & Sons, Inc. Jrl Fut Mark 20:661–685, 2000
Air exposure induced squamous metaplasia of human limbal epithelium.

PURPOSE Squamous metaplasia is a pathologic process that frequently occurs in nonkeratinized stratified ocular surface epithelia. The mechanism for this occurrence is largely unknown except for vitamin A deficiency. METHODS Human limbal explants were cultured under airlift with or without p38 mitogen-activated protein kinase (MAPK) inhibitor SB203580 or in a submerged manner for different durations up to 2 weeks. Epithelial cell proliferation, differentiation, limbal stem cell maintenance, and expansion were studied using certain markers such as Ki67, p63, K10 and K12 keratins, filaggrin, Pax6, ABCG-2, and Musashi-1. Expression of phospho-p38 MAPK and its downstream transcription factors, C/EBPalpha and C/EBPbeta, were studied by immunohistochemistry. Epithelial cells harvested from explants after 2 weeks of culturing under different conditions were seeded onto 3T3 feeder layers and cultured for 12 days. The differentiation of clonal epithelial cells was investigated by double staining to K12 and K10 keratins. RESULTS The squamous metaplasia model was successfully created by culturing human limbal explants at an air-liquid interface (airlift) for 2 weeks. Increased stratification and hyperproliferation only happened in the limbal, but not the corneal, epithelium in airlift, but not submerged, cultures. Epithelial proliferation was associated with a transient increase of limbal epithelial stem cells. Abnormal epidermal differentiation-evidenced by positive expression of K10 keratin in suprabasal cells and filaggrin in superficial cells-ensued. Clones generated from epithelial cells harvested from airlift culture only expressed K12 keratin without K10. As early as 2 days in airlift cultures, p38 expression emerged in limbal basal epithelial cells and gradually extended to the cytoplasm and nuclei. Furthermore, addition of the p38 inhibitor SB203580 abolished abnormal epidermal differentiation without affecting limbal epithelial proliferation. Expression of C/EBPalpha and C/EBPbeta, downstream of the p38 MAPK signaling pathway, was strongly induced by airlift culture and partially was inhibited by SB203580. CONCLUSIONS Dryness resulting from exposure activates p38 MAPK signaling coupled with abnormal epidermal differentiation without intrinsic alteration of stem cells in the limbus. On the ocular surface, p38 inhibitors may have the potential to revert the pathologic process of squamous metaplasia induced by dryness.
Closed-loop direct parametric identification of magnetohydrodynamic normal modes spectra in EXTRAP-T2R reversed-field pinch

The reversed-field pinch (RFP) EXTRAP-T2R (T2R) is a plasma physics experiment with particular relevance for magnetic confinement fusion (MCF) research. T2R is very well equipped for investigations of magnetohydrodynamic (MHD) instabilities known as resistive-wall modes (RWMs), growing on a time-scale set by a surrounding non-perfectly conducting shell. The RWM instability is also subject of intense research in tokamak experiments (another MCF configuration). Recently, multiple RWMs have been stabilized in T2R using arrays of active (current-carrying) and sensor (voltage-measuring) coils equidistributed on the shell. In this paper, the MHD normal modes dynamics is probed in the required feedback operation by simultaneously, and pseudo-randomly, exciting the spectrum in the spatial sense. Spectra are then extracted by predictionerror minimization based on an observer that tracks dynamically aliased modes and the results thus obtained are related, and compared, to established linear MHD stability theory. This pioneer study at T2R is, arguably, appealling both to plasma physicists and automatic control staff.
Family predictors of antisocial behavior in adolescence.

The goal of the present study was to examine the combined and unique ability of different aspects of family functioning to predict involvement in antisocial behavior in a large nonclinical (community) sample of adolescents. Distinction was made between global (e.g., family socioeconomic status), distal (dispositional characteristics of parents), contextual (family characteristics), and proximal (parent-child interaction) factors that operate within families. Results show that proximal factors were significant predictors of antisocial behavior, independent of their shared variance with other factors. Consistent with the hypothesized mediational model, the effects of distal and contextual factors appear to be mostly indirect: after their association with proximal factors was taken into account, these factors were no longer significantly related to antisocial behavior. The implications of these findings for planning of developmentally appropriate interventions for adolescents and their families are discussed.
Delayed‐type hypersensitivity to a recombinant mycobacterial antigen, MPB64, in guinea pigs sensitized to Mycobacterium tuberculosis or Mycobacterium bovis BCG

Recombinant MPB64 (rMPB64), a mycobacterial antigen, was obtained from an Escherichia coli clone transformed with a recombinant expression vector, pMAL64c. The rMPB64 was examined for the activity to elicit delayed‐type hypersensitivity (DTH) in guinea pigs injected with live Mycobacterium tuberculosis H37Rv or live M. bovis BCG Tokyo. It was found that rMPB64 has the same reactivity as native MPB64 (nMPB64) or MPT64 (nMPT64) and the potency to elicit DTH was 13.4 times higher than that of PPD. Because MPB64 is secreted only by living M. tuberculosis and some strains of BCG, it is possible to use this antigen for the diagnosis of tuberculosis. J. Leukoc. Biol. 57: 221–225; 1995.
Childhood meningitis increases the risk for adult schizophrenia

Objective: We investigated the hypothesis that a meningitic infection in childhood may increase the risk of a psychiatric disorder in adulthood. Method: We conducted a follow-up study of 190 individuals affected by a meningitis infection the first 4 years of life, during an epidemic in São Paulo, Brazil, between 1971 and 1974. As a control group, we investigated 156 siblings of the meningitis patients who were not affected by meningitis at childhood. Results: In the 190 cases of meningitis, we found eight (4.2%) cases of schizophrenia against none in the controls, and 40 (21.0%) cases of life occurrence of psychotic symptoms compared to 12 (7.6%) cases in the control group (P<0.001). We found no differences between the two groups regarding the occurrence of other psychiatric disorders and of neurological soft signs. Conclusion: Meningitis during childhood significantly increased the risk of schizophrenia in particular in adulthood, and of psychosis in general.
Effect of clay content on the small and mid to large strain shear modulus of an unsaturated sand

Abstract The results of a series of laboratory test programme is represented to determine the small and mid to large strain shear modulus of an unsaturated sand mixed with a range of Kaolinite including zero to 30%. These were performed throughout a series of saturated and unsaturated cyclic triaxial loading and bender element tests. The results indicate that slight variation in the degree of saturation from 100 to 95% caused a drastic increment in maximum shear modulus. For the range of mid to large amplitudes of strains, the shear modulus reduction curves tend to decrease within the increment of fine contents. The normalised shear modulus reduction curve also appeared to initially be decreased within the increment of clay content up to 20% and consequently, it was slightly increased.
Influence of Pore Residues on Permeation Properties in the Kv2.1 Potassium Channel. Evidence for a Selective Functional Interaction of K+ with the Outer Vestibule

The Kv2.1 potassium channel contains a lysine in the outer vestibule (position 356) that markedly reduces open channel sensitivity to changes in external [K+]. To investigate the mechanism underlying this effect, we examined the influence of this outer vestibule lysine on three measures of K+ and Na+ permeation. Permeability ratio measurements, measurements of the lowest [K+] required for interaction with the selectivity filter, and measurements of macroscopic K+ and Na+ conductance, were all consistent with the same conclusion: that the outer vestibule lysine in Kv2.1 interferes with the ability of K+ to enter or exit the extracellular side of the selectivity filter. In contrast to its influence on K+ permeation properties, Lys 356 appeared to be without effect on Na+ permeation. This suggests that Lys 356 limited K+ flux by interfering with a selective K+ binding site. Combined with permeation studies, results from additional mutagenesis near the external entrance to the selectivity filter indicated that this site was located external to, and independent from, the selectivity filter. Protonation of a naturally occurring histidine in the same outer vestibule location in the Kv1.5 potassium channel produced similar effects on K+ permeation properties. Together, these results indicate that a selective, functional K+ binding site (e.g., local energy minimum) exists in the outer vestibule of voltage-gated K+ channels. We suggest that this site is the location of K+ hydration/dehydration postulated to exist based on the structural studies of KcsA. Finally, neutralization of position 356 enhanced outward K+ current magnitude, but did not influence the ability of internal K+ to enter the pore. These data indicate that in Kv2.1, exit of K+ from the selectivity filter, rather than entry of internal K+ into the channel, limits outward current magnitude. We discuss the implications of these findings in relation to the structural basis of channel conductance in different K+ channels.
Coding Theorems via Jar Decoding

In the development of digital communication and information theory, every channel decoding rule has resulted in a revolution at the time when it was invented. In the area of information theory, early channel coding theorems were established mainly by maximum likelihood decoding, while the arrival of typical sequence decoding signaled the era of multi-user information theory, in which achievability proof became simple and intuitive. Practical channel code design, on the other hand, was based on minimum distance decoding at the early stage. The invention of belief propagation decoding with soft input and soft output, leading to the birth of turbo codes and low-density-parity check (LDPC) codes which are indispensable coding techniques in current communication systems, changed the whole research area so dramatically that people started to use the term “modern coding theory” to refer to the research based on this decoding rule. In this thesis, we propose a new decoding rule, dubbed jar decoding, which would be expected to bring some new thoughts to both the code performance analysis and the code design. Given any channel with input alphabet X and output alphabet Y , jar decoding rule can be simply expressed as follows: upon receiving the channel output y ∈ Y, the decoder first forms a set (called a jar) of sequences x ∈ X n considered to be close to y and pick any codeword (if any) inside this jar as the decoding output. The way how the decoder forms the jar is defined independently with the actual channel code and even the channel statistics in certain cases. Under this jar decoding, various coding theorems are proved in this thesis. First of all, focusing on the word error probability, jar decoding is shown to be near optimal by the achievabilities proved via jar decoding and the converses proved via a proof technique, dubbed the outer mirror image of jar, which is also quite related to jar decoding. Then a Taylor-type expansion of optimal channel coding rate with finite block length is discovered by combining those achievability and converse theorems, and it is demonstrated that jar decoding is optimal up to the second order in this Taylor-type expansion. Flexibility of jar decoding is then illustrated by proving LDPC coding theorems via jar decoding, where the bit error probability is concerned. And finally, we consider a coding scenario, called interactive encoding and decoding, and show that jar decoding can be also used to prove coding theorems and guide the code design in the scenario of two-way communication.
Comparing the Neuropsychiatric Profile of Patients with Alzheimer Disease Who Present Spared versus Impaired Executive Functioning

Background. A "dysexecutive" group of patients with Alzheimer disease (AD) has been previously identified, and these patients have been found to present higher frequency of psychiatric symptoms and more pronounced functional impact. This study aimed at evaluating the frequency of neuropsychiatric symptoms in patients with early AD who present with impaired executive functioning. Methods. Thirty patients with early AD diagnosis were divided into a spared (SEF) and an impaired (IEF) executive functioning group according to their performance scores on neuropsychological tests. Their closest relatives or caregivers completed the Cambridge behavioral inventory (CBI), which assesses behavioral symptoms grouped into 13 categories. Results. A significant difference was exclusively found between SEF and IEF in terms of the frequency of stereotypies and repetitive motor behavior (U = 60.5, P = .024). Conclusions. The presence of stereotypies could be associated with a dysexecutive profile in AD patients. These results shed light on the role of frontal circuitry in the expression of motor symptoms in AD and prompt for further research that will contribute to the differential diagnosis both of different subtypes of AD and other types of dementia.
Effect of Some Medicinal Plant Extracts on Damping-off Disease of Winter Vegetable

Effect of some plant extracts against damping-off disease of some winter vegetable was studied in the net house. Seed treatment with neem leaf, garlic clove, allamonda leaf, ginger rhizome, kalijira seed, bel leaf, turmeric rhizome, katamehedi leaf and onion bulb were evaluated against damping-off, seed germination and growth characters of tomato, eggplant and chilli seedlings. All the treatments were significantly reduced percent damping-off of these three vegetable over untreated control. The most effective treatment was neem leaf extract followed by garlic clove and allamonda leaf extracts in terms of suppressing damping-off disease incidence with increasing plant growth characters. The seed germination of three vegetable seedlings was also increased after sowing plant extracts treated seed in the pot. The highest seed germination of tomato (86.67 %), eggplant (86.33%) and chilli (90.33%) was recorded after seed treatment with neem leaf extract. Neem leaf extracts showed the best effect on reducing damping-off and increasing germination as well as growth characters of vegetable seedling. Garlic clove extract and allamonda leaf extract showed the better result followed by neem leaf extract in reducing percent damping-off of tomato, eggplant and chilli seedlings.