Miracle-dz/UniFAR-FTUs huggingface dataset:
Emotion recognition and theory of mind deficits in children with attention deficit hyperactivity disorder

Objective: Children diagnosed with attention deficit hyperactivity disorder (ADHD) appear to represent insufficient social behavior. Emotion recognition and theory of mind (ToM) abilities are the main domains of social cognition. The purpose of the study was to evaluate the emotion recognition and ToM abilities of children with ADHD. Methods: Sixty-nine patients diagnosed with ADHD and 69 typically developing children participated as the control group in this study. ToM Tasks, Comprehension Test (CT) and Unexpected Outcomes Test (UOT) were applied in both groups. Results: According to the first order ToM Task scores, second order ToM Task scores and total scores of ToM Task, ADHD group have significantly lower scores compared to the controls. In addition, cases in the study group performed poorly on CT and UOT. The findings showed positive correlation between total ToM scores and UOT scores, ToM scores and CT scores, UOT scores and CT scores. Conclusion: Our results clearly revealed that children with ADHD encounter problems with ToM and emotion recognition. Elucidating the deficits in emotion recognition and ToM may contribute to the development of proper interventions in the children with ADHD.
CAN KINDERGARTEN CHILDREN BE SUCCESSFULLY INVOLVED IN PROBABILISTIC TASKS?

SUMMARY This paper describes a classroom teaching experiment, concerning the concept of probability, with children aged 5 in a kindergarten school. The teaching experiment was based on constructivist and interactionist theories about the learning of school mathematics and lasted one month. The collection of the information was based on the tape-recorded interviews with the children (each child was interviewed prior to the research program, at the end of the program and one month later) and the videotaped teaching sessions. During the program, we identified three critical steps in the development of the children’s probabilistic thinking: a) the interpretation of the “different” outcomes in a two stage experiment, b) the acceptance of the realization of the experiment for resolving their conflicting viewpoints, and c) estimating the outcomes in a problem. At the end of the program the majority of the children managed to overcome their subjective interpretations and seemed to develop a primitive quantitative reasoning in probabilistic tasks.
Written Activity, Representations and Fluency as Predictors of Domain Expertise in Mathematics

The emerging field of multimodal learning analytics evaluates natural communication modalities (digital pen, speech, images) to identify domain expertise, learning, and learning-oriented precursors. Using the Math Data Corpus, this research investigated students' digital pen input as small groups collaborated on solving math problems. Compared with non-experts, findings indicated that domain experts have an opposite pattern of accelerating total written activity as problem difficulty increases, a lower written and spoken disfluency rate, and they express different content--including a higher ratio of nonlinguistic symbolic representations and structured diagrams to elemental marks. Implications are discussed for developing reliable multimodal learning analytics systems that incorporate digital pen input to automatically track the consolidation of domain expertise. This includes prediction based on a combination of activity patterns, fluency, and content analysis. New MMLA systems are expected to have special utility on cell phones, which already have multimodal interfaces and are the dominant educational platform worldwide.
ARTICLE IN PRESS The Validity and Reliability of the Turkish Version of the Inventory of Statements About Self-injury 2

SUMMARY Objective: Non-suicidal self-injury (NSSI) is defined as the repetitive deliberate destruction of one’s body tissue without suicidal intent and is frequently repetitive. The aim of this study was to examine the psychometric properties of the Inventory of Statements About Self-injury (ISAS), a measure designed to comprehensively assess non-suicidal self-injury (NSSI). The ISAS assesses 13 functions of NSSI, as well as the frequency of 12 NSSI behaviors. Method: The ISAS was administered to 529 high school students who had performed at least one NSSI behavior. The internal consistency and test-retest reliability of the scale were examined; for construct validity, the relationship between the Turkish form of the ISAS and various criteria scales was examined, and confirmatory factor analysis (CFA) was conducted. Results: Consistent with previous research, factor analysis of the functions scale confirmed the good-fit of the original’s 2-dimension model (χ²=243; s.d. = 59; NCI (χ²/sd) = 4; RMSEA = 0.08 (.07-.09); CFI=0.97; NFI=0.97). In order to test the scale for construct validity, the Brief Symptom Inventory and Suicide Probability Scale were administered to participants, in addition to the ISAS, and the correlations with clinical constructs (e.g., suicidality, depression, anxiety) were in the expected direction. Also the reliability analysis revealed that the ISAS subscales demonstrated high internal consistency. Conclusion: In the light of the findings, it was concluded that the Turkish version of ISAS could be used as a reliable and valid tool in assessing non-suicidal self-injury in research and treatment contexts.
Impact on hypertension control of a patient-held guideline: a randomised controlled trial.

BACKGROUND Hypertension is generally poorly controlled in primary care. One possible intervention for improving control is the harnessing of patient expertise through education and encouragement to challenge their care. AIM To determine whether encouraging patients to manage their hypertension in an 'expert' manner, by providing them with information in a clear clinical guideline, coupled with an explicit exhortation to become involved in and to challenge their own care if appropriate, would improve their care. DESIGN OF STUDY Single blind randomised controlled trial of detailed guideline versus standard information. SETTING Single urban general practice over 1 year. METHOD Patient-held guideline with written explicit exhortation to challenge care when appropriate. Two hundred and ninety-four of 536 eligible patients on the practice hypertension register were recruited, all of whom were randomised into one of two groups. Two hundred and thirty-six patients completed the study. RESULTS PRIMARY OUTCOME average systolic blood pressure. SECONDARY OUTCOMES proportion of patients with blood pressure < 150 mmHg systolic and < 90 mmHg diastolic, average cholesterol, proportion of patients prescribed statins and aspirin according to guideline, hospital anxiety and depression score. No clinically, or statistically significant differences were found between intervention and control with respect to all parameters or in anxiety and depression levels. Statin and aspirin use improved throughout the course of the study in both groups. Statin use showed a trend (P = 0.02) in favour of control. CONCLUSION In this study there was no clinically significant perceived benefit to patients as a result of providing them with a hypertension guideline. Patient guidelines are currently planned for many chronic illnesses. It is important to determine the utility of such interventions before scarce resources are applied to them.
Keeping Teachers Happy: Job Satisfaction among Primary School Teachers in Rural Northwest China

Numerous empirical studies from developing countries have noted that parental education has a robust and positive effect on child learning, a result that is often attributed to more educated parents making greater investments in their children's human capital. However, the nature of any such investment has not been well understood. This study examines how parental education affects various parental investments in goods and time used in children's human capital production via an unusually detailed survey from rural China. It is found that more educated parents make greater educational investments in both goods and time and that these relationships are generally robust to a rich set of controls. Evidence suggests that making greater investments in both goods and time stems both from higher expected returns to education for children and from different preferences for education among more educated parents. A second key finding is that the marginal effect of mother's education on educational investments is generally larger than that of father's education. Disciplines International and Comparative Education Comments Copyright The University of Chicago Press. Reprinted from Comparative Education Review, Volume 49, Issue 2, May 2005, pages 173-204. Publisher URL: http://dx.doi. org/10.1086/503582 This journal article is available at ScholarlyCommons: http://repository.upenn. edu/gansu_papers/1 Comparative Education Review, vol. 49, no. 2. 2005 by the Comparative and International Education Society. All rights reserved. 0010-4086/2005/4902-0003$05.00 Comparative Education Review 173 Keeping Teachers Happy: Job Satisfaction among Primary School Teachers in Rural Northwest China TANJA SARGENT AND EMILY HANNUM
Molecular mechanisms of luteinization

Dynamic changes in steroidogenesis occur in ovarian granulosa cells during ovulation after the LH surge. The ovulatory LH surge induces rapid up-regulation of steroidogenic acute regulatory (StAR) protein and rapid down-regulation of aromatase (Cyp19a1) in granulosa cells undergoing luteinization during ovulation. These rapid changes in StAR and Cyp19a1 gene expression after the LH surge efficiently facilitate progesterone production, which plays a crucial role in ovulation and the following luteinization. Recently, it has become clear that epigenetic regulation such as histone modifications and DNA methylation play a key role in gene expression through the chromatin remodeling of the promoter region. This study reports the in vivo evidence that epigenetic mechanisms including histone modifications, DNA methylation and chromatin remodeling are involved in the rapid changes of StAR and Cyp19a1 gene expression in granulosa cells undergoing luteinization during ovulation.
Biomechanics of lateral lumbar interbody fusion constructs with lateral and posterior plate fixation: laboratory investigation.

OBJECT Lumbar interbody fusion is indicated in the treatment of degenerative conditions. Laterally inserted interbody cages significantly decrease range of motion (ROM) compared with other cages. Supplemental fixation options such as lateral plates or spinous process plates have been shown to provide stability and to reduce morbidity. The authors of the current study investigate the in vitro stability of the interbody cage with a combination of lateral and spinous process plate fixation and compare this method to the established bilateral pedicle screw fixation technique. METHODS Ten L1-5 specimens were evaluated using multidirectional nondestructive moments (± 7.5 N · m), with a custom 6 degrees-of-freedom spine simulator. Intervertebral motions (ROM) were measured optoelectronically. Each spine was evaluated under the following conditions at the L3-4 level: intact; interbody cage alone (stand-alone); cage supplemented with lateral plate; cage supplemented with ipsilateral pedicle screws; cage supplemented with bilateral pedicle screws; cage supplemented with spinous process plate; and cage supplemented with a combination of lateral plate and spinous process plate. Intervertebral rotations were calculated, and ROM data were normalized to the intact ROM data. RESULTS The stand-alone laterally inserted interbody cage significantly reduced ROM with respect to the intact state in flexion-extension (31.6% intact ROM, p < 0.001), lateral bending (32.5%, p < 0.001), and axial rotation (69.4%, p = 0.002). Compared with the stand-alone condition, addition of a lateral plate to the interbody cage did not significantly alter the ROM in flexion-extension (p = 0.904); however, it was significantly decreased in lateral bending and axial rotation (p < 0.001). The cage supplemented with a lateral plate was not statistically different from bilateral pedicle screws in lateral bending (p = 0.579). Supplemental fixation using a spinous process plate was not significantly different from bilateral pedicle screws in flexion-extension (p = 0.476). The combination of lateral plate and spinous process plate was not statistically different from the cage supplemented with bilateral pedicle screws in all the loading modes (p ≥ 0.365). CONCLUSIONS A combination of lateral and spinous process plate fixation to supplement a laterally inserted interbody cage helps achieve rigidity in all motion planes similar to that achieved with bilateral pedicle screws.
Short Fuses & Bad Tempers: Neurocognitive Insights in Trait Anger

The principal aim of this thesis was to improve our understanding of (neuro)cognitive processes involved in anger and a disposition towards anger (i.e., trait anger). __Main conclusions__ Based on the results of the studies described in this thesis, several conclusions can be drawn. First, it can be concluded that the Dutch version of the STAXI-2 is a reliable instrument to assist the clinical practitioner or researcher in measuring the experience, expression, and control of anger. Second, trait anger seems to be related to deficits in cognitive control under both neutral and anger-inducing conditions, of which error-processing deficits seem to be most consistently related to trait anger. Reduced anger-primed inhibitory control in relation to trait anger, however, could not be consistently confirmed. Finally, the studies described in this thesis showed that although angry rumination and mental fatigue seem to be accompanied by increased anger, these processes seem to have little effect on cognitive control. Overall, the current thesis increased knowledge about the impact of neurocognitive processes in relation to trait anger. At the same time, this thesis highlights that more research is needed in order to explore the impact of neurocognitive processes on trait anger as well as their interrelations.
Surreptitious sympatry: Exploring the ecological and genetic separation of two sibling species

Abstract Climate change is having profound impacts on animal populations, and shifts in geographic range are predicted in response. Shifts that result in range overlap between previously allopatric congeneric species may have consequences for biodiversity through interspecific competition, hybridization, and genetic introgression. Harbor seals (Phoca vitulina) and spotted seals (Phoca largha) are parapatric sibling species and areas of co‐occurrence at the edges of their range, such as Bristol Bay, Alaska, offer a unique opportunity to explore ecological separation and discuss potential consequences of increased range overlap resulting from retreating sea ice. Using telemetry and genetic data from 14 harbor seals and six spotted seals, we explored the ecological and genetic separation of the two species by comparing their utilization distributions, distance from haul‐out, dive behavior (e.g., depth, duration, focus), and evidence of hybridization. Firstly, we show that harbor and spotted seals, which cannot be visually distinguished definitively in all cases, haul‐out together side by side in Bristol Bay from late summer to early winter. Secondly, we observed subtle rather than pronounced differences in ranging patterns and dive behavior during this period. Thirdly, most spotted seals in this study remained close to shore in contrast to what is known of the species in more northern areas, and lastly, we did not find any evidence of hybridization. The lack of distinct ecological separation in this area of sympatry suggests that interspecific competition could play an important role in the persistence of these species, particularly if range overlap will increase as a result of climate‐induced range shifts and loss of spotted seal pagophilic breeding habitat. Our results also highlight the added complexities in monitoring these species in areas of suspected overlap, as they cannot easily be distinguished without genetic analysis. Predicted climate‐induced environmental change will likely influence the spatial and temporal extent of overlap in these two sibling species. Ultimately, this may alter the balance between current isolating mechanisms with consequences for species integrity and fitness.
Health and Quality of Life Outcomes

Background: The impact of dizziness on quality of life is often assessed by the Dizziness Handicap Inventory (DHI), which is used as a discriminate and evaluative measure. The aim of the present study was to examine reliability and validity of a translated Norwegian version (DHI-N), also examining responsiveness to important change in the construct being measured. Methods: Two samples (n = 92 and n = 27) included participants with dizziness of mainly vestibular origin. A cross-sectional design was used to examine the factor structure (exploratory factor analysis), internal consistency (Cronbach's α), concurrent validity (Pearson's product moment correlation r), and discriminate ability (ROC curve analysis). Longitudinal designs were used to examine test-retest reliability (intraclass correlation coefficient (ICC) statistics, smallest detectable difference (SDD)), and responsiveness (Pearson's product moment correlation, ROC curve analysis; area under the ROC curve (AUC), and minimally important change (MIC)). The DHI scores range from 0 to 100. Results: Factor analysis revealed a different factor structure than the original DHI, resulting in dismissal of subscale scores in the DHI-N. Acceptable internal consistency was found for the total scale (α = 0.95). Concurrent correlations between the DHI-N and other related measures were moderate to high, highest with Vertigo Symptom Scale-short form-Norwegian version (r = 0.69), and lowest with preferred gait (r = 0.36). The DHI-N demonstrated excellent ability to discriminate between participants with and without 'disability', AUC being 0.89 and best cut-off point = 29 points. Satisfactory test-retest reliability was demonstrated, and the change for an individual should be ≥ 20 DHI-N points to exceed measurement error (SDD). Correlations between change scores of DHI-N and other self-report measures of functional health and symptoms were high (r = 0.50 0.57). Responsiveness of the DHI-N was excellent, AUC = 0.83, discriminating between self-perceived 'improved' versus 'unchanged' participants. The MIC was identified as 11 DHI-N points. Conclusions: The DHI-N total scale demonstrated satisfactory measurement properties. This is the first study that has addressed and demonstrated responsiveness to important change of the DHI, and provided values of SDD and MIC to help interpret change scores. Published: 21 December 2009 Health and Quality of Life Outcomes 2009, 7:101 doi:10.1186/1477-7525-7-101 Received: 12 March 2009 Accepted: 21 December 2009 This article is available from: http://www.hqlo. com/content/7/1/101 © 2009 Tamber et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
On extreme atmospheric and marine nitrogen fluxes and chlorophyll-a levels in the Kattegat Strait

Abstract. A retrospective analysis is carried out to investigate the importance of the vertical fluxes of nitrogen to the marine sea surface layer in which high chlorophyll a levels may cause blooms of harmful algae and subsequent turn over and oxygen depletion at the bottom of the sea. Typically nitrogen is the limiting factor for phytoplankton in the Kattegat Strait during summer periods (May to August) and the major nitrogen inputs come from the atmosphere and deep-water entrainment. The extreme reoccurrence values of nitrogen from atmospheric wet and dry deposition and deep-water flux entrainments are calculated by the periodic maximum method and the results are successfully compared to a map of chlorophyll return periods based on in-situ observations. The one-year return of extreme atmospheric wet deposition is around 60 mg N m -2 day -1 and 30 mg N m -2 day -1 for deep-water entrainment. Atmospheric nitrogen dry deposition is insignificant in the context of algal blooms. At longer time-scales e.g. at 10-year return, the nitrogen deep-water entrainment is larger than the extreme of atmospheric wet deposition. This indicates that the pool of nitrogen released from the sea bottom by deep-water entrainment forced by high winds greatly exceeds the atmospheric pool of nitrogen washed out by precipitation. At the frontal zone of the Kattegat Strait and Skagerrak, the nitrogen deep-water entrainment is very high and this explains the high 10-year return chlorophyll level at 8 mg m -3 in the Kattegat Strait. In the southern part, the extreme chlorophyll level is only 4 mg m -3 according to the statistics of a multi-year time-series of water samples. The chlorophyll level varies greatly in time and space as documented by a series of SeaWiFS satellite maps (OC4 v 4 algorithm) of chlorophyll ScanFish and buoy observations from an experimental period in the Kattegat Strait. It is recommended to sample in-situ chlorophyll observation collocated in time to the satellite overpasses of e.g. SeaWiFS and ENVISAT MERIS to ensure improved mapping of the chlorophyll levels in the Danish waters.
Characterization of In Vitro Engineered Human Adipose Tissues: Relevant Adipokine Secretion and Impact of TNF-α

Representative modelling of human adipose tissue functions is central to metabolic research. Tridimensional models able to recreate human adipogenesis in a physiological tissue-like context in vitro are still scarce. We describe the engineering of white adipose tissues reconstructed from their cultured adipose-derived stromal precursor cells. We hypothesize that these reconstructed tissues can recapitulate key functions of AT under basal and pro-inflammatory conditions. These tissues, featuring human adipocytes surrounded by stroma, were stable and metabolically active in long-term cultures (at least 11 weeks). Secretion of major adipokines and growth factors by the reconstructed tissues was determined and compared to media conditioned by human native fat explants. Interestingly, the secretory profiles of the reconstructed adipose tissues indicated an abundant production of leptin, PAI-1 and angiopoietin-1 proteins, while higher HGF levels were detected for the human fat explants. We next demonstrated the responsiveness of the tissues to the pro-inflammatory stimulus TNF-α, as reflected by modulation of MCP-1, NGF and HGF secretion, while VEGF and leptin protein expression did not vary. TNF-α exposure induced changes in gene expression for adipocyte metabolism-associated mRNAs such as SLC2A4, FASN and LIPE, as well as for genes implicated in NF-κB activation. Finally, this model was customized to feature adipocytes representative of progressive stages of differentiation, thereby allowing investigations using newly differentiated or more mature adipocytes. In conclusion, we produced tridimensional tissues engineered in vitro that are able to recapitulate key characteristics of subcutaneous white adipose tissue. These tissues are produced from human cells and their neo-synthesized matrix elements without exogenous or synthetic biomaterials. Therefore, they represent unique tools to investigate the effects of pharmacologically active products on human stromal cells, extracellular matrix and differentiated adipocytes, in addition to compounds modulating adipogenesis from precursor cells.