Miracle-dz/UniFAR-FTUs huggingface dataset:
Information Reduction as Item-general Strategy Change

1 Zusammenfassung.2 Acknowledgements.3 Publications Included.4 Introduction.5 Measuring Information Reduction.6 Theoretical Goals.7 Predictions of Item-specific and Item-general Perspectives . 10 Results.11 Manipulation check – Representation strength was successfully varied.11 Reduction of the string length effect over blocks (1). 11 Equal rates of transfer errors for strings of different frequencies (2). 13 Equal fixations to the irrelevant letters for strings with different frequencies (3). 13 Time course – abruptly and at the same point in time for all strings (4). 14 Item-general Information Reduction at the cost of errors (5). 14 Summary and Discussion.16 Conclusions based on work in the included publications . 16 Broadening the Perspective on Strategy Change.17 Item-general learning of the triplets.17 Data-driven and yet item-general? 20 Studying Information Reduction after it happened outside the lab? 22 Voluntary vs. involuntary performance changes.22 Conclusion.24 References . 25 Erklärung zum Zustandekommen der Arbeit.33
Relationships among Intermodel Spread and Biases in Tropical Atlantic Sea Surface Temperatures

State-of-the-art general circulation models show important systematic errors in their simulation of sea surface temperatures (SST), especially in the tropical Atlantic. In this work the spread in the simulation of climatological SST in the tropical Atlantic by 24 CMIP5 models is examined, and its relationship with the mean systematic biases in the region is explored. The modes of intermodel variability are estimated by applying principal component (PC) analysis to the SSTs in the region 70°W–20°E, 20°S–20°N. The intermodel variability is approximately explained by the first three modes. The first mode is related to warmer SSTs in the basin, shows worldwide connections with same-signed loads over most of the tropics, and is connected with lower low cloud cover over the eastern parts of the subtropical oceans. The second mode is restricted to the Atlantic, where it shows negative and positive loads to the north and south of the equator, respectively, and is connected to a too weak Atlantic meridional overturning circulation (AMOC). The third mode is related to the double intertropical convergence zone bias in the Pacific and to an interhemispheric asymmetry in the net radiation at the top of the atmosphere. The structure of the second mode is closer to the mean bias than that of the others in the tropical Atlantic, suggesting that model difficulties with the AMOC contribute to the regional biases.
Minimum Relative Entropy for Quantum Estimation: Feasibility and General Solution

We propose a general framework for solving quantum state estimation problems using the minimum relative entropy criterion. A convex optimization approach allows us to decide the feasibility of the problem given the data, find the maximal common kernel of all admissible states and, whenever necessary, to relax the constraints in order to allow for a physically admissible solution. Building on these results, the variational analysis can be completed ensuring existence and uniqueness of the optimum. The latter can then be computed by efficient standard algorithms for convex optimization, without resorting to approximate methods or restrictive assumptions on its rank.
BRG1 directly regulates nucleosome structure and chromatin looping of the α globin locus to activate transcription

α globin expression must be regulated properly to prevent the occurrence of α-thalassemias, yet many questions remain unanswered regarding the mechanism of transcriptional activation. Identifying factors that regulate chromatin structure of the endogenous α globin locus in developing erythroblasts will provide important mechanistic insight. Here, we demonstrate that the BRG1 catalytic subunit of SWI/SNF-related complexes co-immunoprecipitates with GATA-1 and EKLF in murine fetal liver cells in vivo and is recruited to the far-upstream major-regulatory element (MRE) and α2 promoter. Furthermore, based on our analysis of Brg1null/ENU1 mutant mice, BRG1 regulates DNase I sensitivity, H3ac, and H3K4me2 but not CpG methylation at both sites. Most importantly, BRG1 is required for chromatin loop formation between the MRE and α2 promoter and for maximal RNA Polymerase II occupancy at the α2 promoter. Consequently, Brg1 mutants express α globin mRNA at only 5–10% of wild-type levels and die at mid-gestation. These data identify BRG1 as a chromatin-modifying factor required for nucleosome remodeling and transcriptional activation of the α globin locus. These data also demonstrate that chromatin looping between the MRE and α2 promoter is required as part of the transcriptional activation mechanism.
Unsupervised Word Mapping Using Structural Similarities in Monolingual Embeddings

Most existing methods for automatic bilingual dictionary induction rely on prior alignments between the source and target languages, such as parallel corpora or seed dictionaries. For many language pairs, such supervised alignments are not readily available. We propose an unsupervised approach for learning a bilingual dictionary for a pair of languages given their independently-learned monolingual word embeddings. The proposed method exploits local and global structures in monolingual vector spaces to align them such that similar words are mapped to each other. We show empirically that the performance of bilingual correspondents that are learned using our proposed unsupervised method is comparable to that of using supervised bilingual correspondents from a seed dictionary.
How does the Time Delay of an ER Fluid's Response Affect Control Performance of Servo-systems?

We previously developed a particle type ER (electro-rheological) fluid damper in which viscosity was controlled continuously in real time for fast and precise positioning of a direct-drive motor. However, particle type ER fluids commonly have about 5-mili seconds response times. This delay needs to be taken into account when electric fields to energize ER fluids are controlled in real time. Especially, servo systems with ER fluid devices have a sampling time for the control loop that is about 1-mili second and so is shorter than the response time of ER fluids. Though the delay in this case has a great possibility of affecting on the performance or stability of servo systems, there is little research in this area that has mentioned the problem. In this paper, I investigated how this time delay affected damping performance and stability of this system.
Delta-6-desaturase Links Polyunsaturated Fatty Acid Metabolism With Phospholipid Remodeling and Disease Progression in Heart Failure

Background— Remodeling of myocardial phospholipids has been reported in various forms of heart failure for decades, but the mechanism and pathophysiological relevance of this phenomenon have remained unclear. We examined the hypothesis that &dgr;-6 desaturase (D6D), the rate-limiting enzyme in long-chain polyunsaturated fatty acid biosynthesis, mediates the signature pattern of fatty acid redistribution observed in myocardial phospholipids after chronic pressure overload and explored plausible links between this process and disease pathogenesis. Methods and Results— Compositional analysis of phospholipids from hearts explanted from patients with dilated cardiomyopathy revealed elevated polyunsaturated fatty acid product/precursor ratios reflective of D6D hyperactivity, manifesting primarily as lower levels of linoleic acid with reciprocally higher levels of arachidonic and docosahexaenoic acids. This pattern of remodeling was attenuated in failing hearts chronically unloaded with a left ventricular assist device. Chronic inhibition of D6D in vivo reversed similar patterns of myocardial polyunsaturated fatty acid redistribution in rat models of pressure overload and hypertensive heart disease and significantly attenuated cardiac hypertrophy, fibrosis, and contractile dysfunction in both models. D6D inhibition also attenuated myocardial elevations in pathogenic eicosanoid species, lipid peroxidation, and extracellular receptor kinase 1/2 activation; normalized cardiolipin composition in mitochondria; reduced circulating levels of inflammatory cytokines; and elicited model-specific effects on cardiac mitochondrial respiratory efficiency, nuclear factor &kgr; B activation, and caspase activities. Conclusions— These studies demonstrate a pivotal role of essential fatty acid metabolism in myocardial phospholipid remodeling induced by hemodynamic stress and reveal novel links between this phenomenon and the propagation of multiple pathogenic systems involved in maladaptive cardiac remodeling and contractile dysfunction.
Efficient Kernel Learning from Side Information Using ADMM

Side information is highly useful in the learning of a nonparametric kernel matrix. However, this often leads to an expensive semidefinite program (SDP). In recent years, a number of dedicated solvers have been proposed. Though much better than off-the-shelf SDP solvers, they still cannot scale to large data sets. In this paper, we propose a novel solver based on the alternating direction method of multipliers (ADMM). The key idea is to use a low-rank decomposition of the kernel matrix K = VTU, with the constraint that V = U. The resultant optimization problem, though non-convex, has favorable convergence properties and can be efficiently solved without requiring eigen-decomposition in each iteration. Experimental results on a number of real-world data sets demonstrate that the proposed method is as accurate as directly solving the SDP, but can be one to two orders of magnitude faster.
Phylogenetic Diversity, Abundance, and Axial Distribution of Bacteria in the Intestinal Tract of Two Soil-Feeding Termites (Cubitermes spp.)

ABSTRACT The hindgut of soil-feeding termites is highly compartmentalized and characterized by pronounced axial dynamics of the intestinal pH and microbial processes such as hydrogen production, methanogenesis, and reductive acetogenesis. Nothing is known about the bacterial diversity and the abundance or axial distribution of the major phylogenetic groups in the different gut compartments. In this study, we showed that the variety of physicochemical conditions is reflected in the diversity of the microbial communities in the different gut compartments of two Cubitermes species (Termitidae: Termitinae). 16S rRNA gene clones from the highly alkaline first proctodeal segment (P1) of Cubitermes orthognathus represented almost exclusively gram-positive bacteria with low G+C content (LGC bacteria). In the posterior gut segments, their proportion decreased progressively, and the clone libraries comprised a variety of phyla, including the Cytophaga-Flexibacter-Bacteroides group, various subgroups of Proteobacteria, and the spirochetes. Phylogenetic analysis revealed that many of the clones clustered with sequences from the guts of other termites, and some even formed clusters containing only clones from C. orthognathus. The abundance and axial distribution of major phylogenetic groups in the gut of Cubitermes ugandensis were determined by fluorescence in situ hybridization with group-specific oligonucleotide probes. While the results were generally in good agreement with those of the clonal analysis, direct counts with probes specific for the Planctomycetales revealed a severe underestimation of representatives of this phylum in the clone libraries. Results obtained with newly designed FISH probes directed against two clusters of LGC clones from C. orthognathus indicated that the clones were restricted to specific gut regions. A molecular fingerprinting analysis published in a companion paper (D. Schmitt-Wagner, M. W. Friedrich, B. Wagner, and A. Brune, Appl. Environ. Microbiol. 69:6018-6024, 2003) corroborated the presence of compartment-specific bacterial communities in the gut of different Cubitermes species.
An Empirical Study of Non-Rigid Surface Feature Matching

This paper presents an empirical study of affine invariant feature detectors to perform matching on video sequences of people with non-rigid surface deformation. Recent advances in feature detection and wide baseline matching have focused on static scenes. Video frames of human movement captures highly non-rigid deformation such as loose hair, cloth creases, skin stretching and free flowing clothing. This study evaluates the performance of three widely used feature detectors for sparse temporal correspondence on single view and multiple view video sequences. Quantitative evaluation is performed of both the number of features detected and their temporal matching against and without ground truth correspondences. Recall-accuracy analysis of feature matching is reported for temporal correspondence on single view and multiple view sequences of people with variation in clothing and movement. This analysis identifies that existing feature detection and matching algorithms are unreliable for fast movement with common clothing. For patterned clothing techniques such as SIFT produce reliable correspondence. (10 pages)
Hypermedia in the virtual project room - toward open 3D spatial hypermedia

This paper discusses hypermedia aspects of the design of a Virtual Project Room. Based on ethnographic and participatory design studies of landscape architects’ and architects' work, prototypes for a notion of virtual project rooms , supporting remote collaboration, is developed. Since (landscape) architects work with 3D objects and environments a natural first step is to design a virtual project room as a 3D virtual environment. The current prototype, Manufaktur, utilizes open hypermedia technology to integrate documents with design models in the virtual project room. Manufaktur provides hot-linking of arbitrary MS Windows documents into the virtual project room, it supports spatial arrangement and categorization of (sub) workspaces by means of proximity, and it provides "classical" open hypermedia linking between segments of documentation. Finally, support for two modes of tightly coupled collaboration in the virtual project room is being provided by means of a session management service. Based on the experiences from design of Manufaktur we discuss design issues for the integration of hypermedia and collaborative virtual environments.
Neuronal activity‐dependent regulation of retinal blood flow

Blood flow in the retina is intrinsically regulated to meet the metabolic demands of its constituent cells. Flickering light or stationary contrast reversals induce an increase in blood flow within seconds of the stimulus onset. This phenomenon is thought to compensate for an increase in ganglion cell activity and energy consumption. Ganglion cell activity is in turn dependent on signals from photoreceptors, bipolar cells, horizontal cells and amacrine cells. The physiological properties of these neurons determine how each type is affected by a particular light characteristic. Neuronal activity then triggers the release of signalling molecules that dilate local blood vessels and increase blood flow. Nitric oxide has been implicated as an important mediator, but metabolites of arachidonic acid may also be involved. Detailed elucidation of these mechanisms, together with advances in imaging technology, may facilitate the use of neurovascular tests to improve the detection of retinal damage in pathological conditions.
Regional brain activation during proximal stomach distention in humans: A positron emission tomography study.

BACKGROUND & AIMS Hypersensitivity to proximal gastric distention due to abnormal central nervous system processing of visceral stimuli has been suggested as a possible underlying pathophysiologic mechanism in functional dyspepsia. However, the cortical regions activated by distention of the proximal stomach have not been identified. The aim of this study was to investigate regional brain activation during painful and nonpainful proximal gastric distention in humans. METHODS Positron emission tomography of the brain was performed in 11 healthy volunteers during 4 conditions: (1) no distention and isobaric distention to the individual thresholds for (2) first, (3) marked, and (4) unpleasant sensation. Data were analyzed using statistical parametric mapping. RESULTS During maximal distention relative to baseline, significant (P corrected <.05) regional brain activation occurred in the left and right gyrus postcentralis (Brodmann area [BA] 43), the left gyrus temporalis superior (BA 38), the right gyrus frontalis inferior (BA 47, orbitofrontal cortex), the right midanterior cingulate gyrus (BA 24), the right anterior insula, and the left cerebellar hemisphere. These areas showed a progressive increase in activation with increasing intensity of the distending stimulus. CONCLUSIONS We found evidence for a neuronal network processing distention stimuli of the proximal stomach that is overall consistent with the "visceral stimulation network" described in the literature. In addition, we found activation of the orbitofrontal cortex, confirming its role as a convergence zone for processing of food-related stimuli and regulation of hunger, appetite, satiety, and food intake. We found no evidence for a functional neuroanatomic divergence in the processing of noxious and innocuous gastric stimuli.
Congenital Dislocation of the Knee

of the meniscus from degenerative changes, and movement causes microscopic tears and more adhesion formation. To resolve the symptoms and prevent the horizontal tear occurring we advocate manipulation under anaesthetic to regain rotation, with injection of hydrocortisone to prevent further adhesion formation. Meniscectomy is reserved for those patients with sufficient persistent symptoms to warrant operation.
High Vascular Tone of Mouse Femoral Arteries In Vivo Is Determined by Sympathetic Nerve Activity Via α1A- and α1D-Adrenoceptor Subtypes

Background and purpose Determining the role of vascular receptors in vivo is difficult and not readily accomplished by systemic application of antagonists or genetic manipulations. Here we used intravital microscopy to measure the contributions of sympathetic receptors, particularly α1-adrenoceptor subtypes, to contractile activation of femoral artery in vivo. Experimental approach Diameter and intracellular calcium ([Ca2+]i) in femoral arteries were determined by intravital fluorescence microscopy in mice expressing a Myosin Light Chain Kinase (MLCK) based calcium-calmodulin biosensor. Pharmacological agents were applied locally to the femoral artery to determine the contributions of vascular receptors to tonic contraction and [Ca2+]i,. Key results In the anesthetized animal, femoral arteries were constricted to a diameter equal to 54% of their passive diameter (i.e. tone = 46%). Of this total basal tone, 16% was blocked by RS79948 (0.1 µM) and thus attributable to α2-adrenoceptors. A further 46% was blocked by prazosin (0.1 µM) and thus attributable to α1-adrenoceptors. Blockade of P2X and NPY1 receptors with suramin (0.5 mM) and BIBP3226 (1.0 µM) respectively, reduced tone by a further 22%, leaving 16% of basal tone unaffected at these concentrations of antagonists. Application of RS100329 (α1A-selective antagonist) and BMY7378 (α1D-selective) decreased tone by 29% and 26%, respectively, and reduced [Ca2+]i. Chloroethylclonidine (1 µM preferential for α1B-) had no effect. Abolition of sympathetic nerve activity (hexamethonium, i.p.) reduced basal tone by 90%. Conclusion and Implications Tone of mouse femoral arteries in vivo is almost entirely sympathetic in origin. Activation of α1A- and α1D-adrenoceptors elevates [Ca2+]i and accounts for at least 55% of the tone.
UHF PD Online Monitoring of Huge-Size Transformers and Data Analysis

It is widely accepted that failures due to insulation defects are often preceded by some form of PD activities in HV equipments. This paper describes practical application of the UHF PD detection on a new oil-immersed power transformer. An internal UHF sensor was designed and installed to the transformer for insulation condition assessment. As the frequency band of this UHF sensor was 300~1500MHz, envelope detection technique was used to extract UHF signals excited from PD sources inside the transformer. The results of MATLAB simulation and experimental measurements have shown that UHF PD signals can be effectively extracted by this method. Using the monitoring system established in this paper, typical UHF PD patterns were recorded during PD acceptance test, which reveal that UHF PD measurements can detect small level of discharges with good sensitivity. Finally, online monitoring data including strong external disturbances such as lightning strikes, switching operation pulses was studied.
Capture–recapture analysis with a latent class model allowing for local dependence and observed heterogeneity

In epidemiology, capture–recapture models are commonly used to estimate the size of an unknown population based on several incomplete lists of individuals. The method operates under two main assumptions: independence between the lists (local independence) and homogeneity of capture probabilities of individuals. In practice, these assumptions are rarely satisfied. We introduce a multinomial latent class model that can account for both list dependence and heterogeneity. Parameter estimation is performed by maximizing the conditional likelihood function with the use of the EM algorithm. In addition, a new approach for evaluating the standard errors of the parameter estimates is discussed, which considerably reduces the computational burden associated with the evaluation of the variance of the population size estimate.
Probable impact of age and hypoxia on proliferation and microRNA expression profile of bone marrow-derived human mesenchymal stem cells

Decline in the therapeutic potential of bone marrow-derived mesenchymal stem cells (MSC) is often seen with older donors as compared to young. Although hypoxia is known as an approach to improve the therapeutic potential of MSC in term of cell proliferation and differentiation capacity, its effects on MSC from aged donors have not been well studied. To evaluate the influence of hypoxia on different age groups, MSC from young (<30 years) and aged (>60 years) donors were expanded under hypoxic (5% O2) and normal (20% O2) culture conditions. MSC from old donors exhibited a reduction in proliferation rate and differentiation potential together with the accumulation of senescence features compared to that of young donors. However, MSC cultured under hypoxic condition showed enhanced self-renewing and proliferation capacity in both age groups as compared to normal condition. Bioinformatic analysis of the gene ontology (GO) and KEGG pathway under hypoxic culture condition identified hypoxia-inducible miRNAs that were found to target transcriptional activity leading to enhanced cell proliferation, migration as well as decrease in growth arrest and apoptosis through the activation of multiple signaling pathways. Overall, differentially expressed miRNA provided additional information to describe the biological changes of young and aged MSCs expansion under hypoxic culture condition at the molecular level. Based on our findings, the therapeutic potential hierarchy of MSC according to donor’s age group and culture conditions can be categorized in the following order: young (hypoxia) > young (normoxia) > old aged (hypoxia) > old aged (normoxia).