Miracle-dz/UniFAR-FTUs huggingface dataset:
Association Between Matrix Metalloproteinase-3 Activity and Glomerular Filtration Rate and Albuminuria Status in Patients With Type 2 Diabetes Mellitus.

INTRODUCTION Diabetic nephropathy is pictured as matrix accumulation and thickening of glomerular basal membrane. Matrix metalloproteinases (MMPs) are major proteases involved in extracellular matrix degradation. Moreover, plasminogen activator inhibitor-1 (PAI-1) primarily regulates plasmin dependent proteolysis. It plays a role in renal fibrosis causing extracellular matrix accumulation through inhibition of plasmin-dependent extracellular matrix degradation. This study investigated PAI-1 serum level and MMP-3 activity and their correlation with glomerular filtration rate in patients with diabetes mellitus. MATERIALS AND METHODS In a case-control design, serum PAI-1 concentrations and MMP-3 activity were measured in 80 patients with normoalbuminuria, microalbuminuria, and macroalbuminuria. Receiver operating characteristics curve analysis was used to assess the diagnostic accuracy of MMP-3 activity in discriminating albuminuria. RESULTS In the patients with microalbuminuria, serum PAI-1 levels were higher compared with macroalbuminuric patients (P < .001). The patients with macroalbuminuria exhibited a significantly lower MMP-3 activity than the patients with microalbuminuria and normoalbuminuria (P < .001). No significant correlation was found between serum MMP-3 activity and serum PAI-1 levels in those with normoalbuminuria, microalbuminuria, and macroalbuminuria. The MMP-3 activity had a strong positive correlation with estimated glomerular filtration (r = 0.853, P < .001). CONCLUSIONS We found that there was a positive correlation between glomerular filtration rate and MMP-3 activity in diabetic patients. This concludes that MMP-3 may have a role in the pathogenesis of diabetic nephropathy progressions towards macroalbuminuria, and therefore, MMP-3 activity may be used in evaluating albuminuria status.
Human Communication Dynamics in Digital Footsteps: A Study of the Agreement between Self-Reported Ties and Email Networks

Digital communication data has created opportunities to advance the knowledge of human dynamics in many areas, including national security, behavioral health, and consumerism. While digital data uniquely captures the totality of a person's communication, past research consistently shows that a subset of contacts makes up a person's “social network” of unique resource providers. To address this gap, we analyzed the correspondence between self-reported social network data and email communication data with the objective of identifying the dynamics in e-communication that correlate with a person's perception of a significant network tie. First, we examined the predictive utility of three popular methods to derive social network data from email data based on volume and reciprocity of bilateral email exchanges. Second, we observed differences in the response dynamics along self-reported ties, allowing us to introduce and test a new method that incorporates time-resolved exchange data. Using a range of robustness checks for measurement and misreporting errors in self-report and email data, we find that the methods have similar predictive utility. Although e-communication has lowered communication costs with large numbers of persons, and potentially extended our number of, and reach to contacts, our case results suggest that underlying behavioral patterns indicative of friendship or professional contacts continue to operate in a classical fashion in email interactions.
Minimum Abutment Height to Eliminate Bone Loss: Influence of Implant Neck Design and Platform Switching.

PURPOSE This retrospective study quantitatively analyzed the minimum prosthetic abutment height to eliminate bone loss after 4.7-mm-diameter implant placement in maxillary bone and how grafting techniques can affect the marginal bone loss in implants placed in maxillary areas. MATERIALS AND METHODS Two different implant types with a similar neck design were singularly placed in two groups of patients: the test group, with platform-switched implants, and the control group, with conventional (non-platform-switched) implants. Patients requiring bone augmentation underwent unilateral sinus augmentation using a transcrestal technique with mineralized xenograft. Radiographs were taken immediately after implant placement, after delivery of the prosthetic restoration, and after 12 months of loading. RESULTS The average mesial and distal marginal bone loss of the control group (25 patients) was significantly more than twice that of the test group (26 patients), while their average abutment height was similar. Linear regression analysis highlighted a statistically significant inverse relationship between marginal bone loss and abutment height in both groups; however, the intercept of the regression line, both mesially and distally, was 50% lower for the test group than for the control group. The marginal bone loss was annulled with an abutment height of 2.5 mm for the test group and 3.0 mm for the control group. No statistically significant differences were found regarding marginal bone loss of implants placed in native maxillary bone compared with those placed in the grafted areas. CONCLUSION The results suggest that the shorter the abutment height, the greater the marginal bone loss in cement-retained prostheses. Abutment height showed a greater influence in platform-switched than in non-platform-switched implants on the limitation of marginal bone loss.
Impact of the type of transcatheter heart valve on the incidence of early subclinical leaflet thrombosis

OBJECTIVES The aim of this study was to investigate whether balloon-expandable and self-expandable transcatheter heart valves (THVs) differ in terms of the incidence of early subclinical leaflet thrombosis (LT). METHODS Electrocardiographic-gated cardiac dual-source computed tomography angiography was performed at a median of 5 days after transcatheter aortic valve implantation and assessed for evidence of LT. RESULTS Of the 629 consecutive patients, 538 (86%) received a balloon-expandable THV and 91 (14%) a self-expandable THV. LT was documented in 77 (14%) patients with a balloon-expandable valve and in 16 (18%) with a self-expandable valve (P = 0.42). Similarly, LT was not significantly related to THV size (P = 0.62). Corresponding to a lower rate of atrial fibrillation in the group with LT [25 (27%) vs 222 (41%), P = 0.01], anticoagulation at the time of computed tomography angiography was less frequent in this group [21 (23%) vs 183 (34%), P = 0.03]. Among the other potentially relevant covariables, there was no significant difference in the clinical baseline and the procedural characteristics between patients with and without LT (age 82 ± 6 years vs 82 ± 6 years, P = 0.51; ejection fraction 49 ± 10% vs 50 ± 10%, P = 0.47). In multivariate logistic regression analysis, including potentially relevant covariables, valve type was not significantly associated with LT (P = 0.36). In the univariate and multivariate analyses, only the lack of anticoagulation at the time of computed tomography angiography was predictive of thrombus formation [0.563 (0.335-0.944), P = 0.03; 0.576 (0.343-0.970), P = 0.04]. CONCLUSIONS In this large retrospective study of 629 patients, the type and the size of THV was not predictive of early LT.
Pericarditis and Pericardial Effusions in End‐Stage Renal Disease

Pericarditis and pericardial effusions are not uncommon in patients with end‐stage renal disease (ESRD). Etiologies include those found in the general population along with two entities unique to patients with kidney disease, namely uremic and dialysis‐associated pericarditis. Uremic pericarditis has been arbitrarily defined as pericarditis that develops before or within 8 weeks of initiation of dialysis, while dialysis‐associated pericarditis is used to define pericarditis in patients on dialysis for more than 8 weeks. Retention of uremic toxins is likely a major contributor to uremic and dialysis‐associated pericarditis although their exact cause is not known. Indeed, whether they are actually distinct entities is uncertain. Symptoms and signs of pericarditis differ in patients with ESRD compared to the non‐ESRD population. Management has not been well studied and ranges from initiation and intensification of dialysis to percutaneous or open drainage for large effusions. This review covers the literature on this topic but emphasizes that most of the data are old and of relatively poor quality, and therefore additional research is needed.
Using Data Mining to Predict Hospital Admissions From the Emergency Department

Crowding within emergency departments (EDs) can have significant negative consequences for patients. EDs therefore need to explore the use of innovative methods to improve patient flow and prevent overcrowding. One potential method is the use of data mining using machine learning techniques to predict ED admissions. This paper uses routinely collected administrative data (120 600 records) from two major acute hospitals in Northern Ireland to compare contrasting machine learning algorithms in predicting the risk of admission from the ED. We use three algorithms to build the predictive models: 1) logistic regression; 2) decision trees; and 3) gradient boosted machines (GBM). The GBM performed better (accuracy = 80.31%, AUC-ROC = 0.859) than the decision tree (accuracy = 80.06%, AUC-ROC = 0.824) and the logistic regression model (accuracy = 79.94%, AUC-ROC = 0.849). Drawing on logistic regression, we identify several factors related to hospital admissions, including hospital site, age, arrival mode, triage category, care group, previous admission in the past month, and previous admission in the past year. This paper highlights the potential utility of three common machine learning algorithms in predicting patient admissions. Practical implementation of the models developed in this paper in decision support tools would provide a snapshot of predicted admissions from the ED at a given time, allowing for advance resource planning and the avoidance bottlenecks in patient flow, as well as comparison of predicted and actual admission rates. When interpretability is a key consideration, EDs should consider adopting logistic regression models, although GBM’s will be useful where accuracy is paramount.
Edinburgh Research Explorer Differentially Private Bayesian Programming

We present PrivInfer , an expressive framework for writing and verifying diﬀerentially private Bayesian machine learning algorithms. Programs in PrivInfer are written in a rich functional probabilistic programming language with constructs for performing Bayesian inference. Then, diﬀerential privacy of programs is established using a relational reﬁnement type system, in which reﬁnements on probability types are indexed by a metric on distributions. Our framework leverages recent developments in Bayesian inference, probabilistic programming languages, and in relational reﬁnement types. We demonstrate the expressiveness of PrivInfer by verifying privacy for several examples of private Bayesian inference.
Randomized Trial of Liposomal Amikacin for Inhalation in Nontuberculous Mycobacterial Lung Disease

Rationale: Lengthy, multidrug, toxic, and low‐efficacy regimens limit management of pulmonary nontuberculous mycobacterial disease. Objectives: In this phase II study, we investigated the efficacy and safety of liposomal amikacin for inhalation (LAI) in treatment‐refractory pulmonary nontuberculous mycobacterial (Mycobacterium avium complex [MAC] or Mycobacterium abscessus) disease. Methods: During the double‐blind phase, patients were randomly assigned to LAI (590 mg) or placebo once daily added to their multidrug regimen for 84 days. Both groups could receive open‐label LAI for 84 additional days. The primary endpoint was change from baseline to Day 84 on a semiquantitative mycobacterial growth scale. Other endpoints included sputum conversion, 6‐minute‐walk distance, and adverse events. Measurements and Main Results: The modified intention‐to‐treat population included 89 (LAI = 44; placebo = 45) patients. The average age of the sample was 59 years; 88% were female; 92% were white; and 80 and 59 patients completed study drug dosing during the double‐blind and open‐label phases, respectively. The primary endpoint was not achieved (P = 0.072); however, a greater proportion of the LAI group demonstrated at least one negative sputum culture (14 [32%] of 44 vs. 4 [9%] of 45; P = 0.006) and improvement in 6‐minute‐walk test (+20.6 m vs. −25.0 m; P = 0.017) at Day 84. A treatment effect was seen predominantly in patients without cystic fibrosis with MAC and was sustained 1 year after LAI. Most adverse events were respiratory, and in some patients it led to drug discontinuation. Conclusions: Although the primary endpoint was not reached, LAI added to a multidrug regimen produced improvements in sputum conversion and 6‐minute‐walk distance versus placebo with limited systemic toxicity in patients with refractory MAC lung disease. Further research in this area is needed. Clinical trial registered with www.clinicaltrials. gov (NCT01315236).
Clustering and hierarchy of financial markets data: advantages of the DBHT

We present a set of analyses aiming at quantifying the amount of information filtered by di↵erent hierarchical clustering methods on correlations between stock returns. In particular we apply, for the first time to financial data, a novel hierarchical clustering approach, the Directed Bubble Hierarchical Tree (DBHT), and we compare it with other methods including the Linkage and k-medoids. In particular by taking the industrial sector classification of stocks as a benchmark partition we evaluate how the di↵erent methods retrieve this classification. The results show that the Directed Bubble Hierarchical Tree outperforms the other methods, being able to retrieve more information with fewer clusters. Moreover, we show that the economic information is hidden at di↵erent levels of the hierarchical structures depending on the clustering method. The dynamical analysis also reveals that the di↵erent methods show di↵erent degrees of sensitivity to financial events, like crises. These results can be of interest for all the applications of clustering methods to portfolio optimization and risk hedging.
Defect‐tolerant nanoelectronic pattern classifiers

Mixed‐signal neuromorphic networks (‘CrossNets’), based on hybrid CMOS/nanodevice circuits, may provide unprecedented performance for important pattern classification tasks. The synaptic weights necessary for such tasks may be imported from an external ‘precursor’ network with either continuous or discrete synaptic weights (in the former case, with the quantization—‘clipping’—due to the binary character of the elementary synaptic nanodevices—latching switches.) Alternatively, the weights may be adjusted ‘in situ’ (inside the CrossNet) using a pseudo‐stochastic method, or set‐up using a mixed‐mode method partly employing external circuitry. Our calculations have shown that CrossNet pattern classifiers, using any of these synaptic weight adjustment methods, may be remarkably resilient. For example, in a CrossNet with synapses in the form of two small square arrays with 4 × 4 nanodevices each, the resulting weight discreteness may have a virtually negligible effect on the classification fidelity, while the fraction of defective devices which affects the performance substantially ranges from ∼20% to as high as 90% (! ), depending on the training method. Copyright © 2007 John Wiley & Sons, Ltd.
Does smallpox vaccination modify HIV disease progression among ART-naive people living with HIV in Africa?

SUMMARY We examined the association between a history of smallpox vaccination and immune activation (IA) in a population of antiretroviral therapy-naïve people living with HIV (PLHIV). A cross-sectional study was conducted in Senegal from July 2015 to March 2017. Smallpox vaccination was ascertained by the presence of smallpox vaccine scar and IA by the plasma level of β-2-microglobulin (β2m). The association was analysed using logistic regression and linear regression models. The study population comprised 101 PLHIV born before 1980 with a median age of 47 years (interquartile range (IQR) = 42–55); 57·4% were women. Smallpox vaccine scar was present in 65·3% and the median β2m level was 2·59 mg/l (IQR = 2·06–3·86). After adjustment, the presence of smallpox vaccine scar was not associated with a β2m level ⩾2·59 mg/l (adjusted odds ratio 0·94; 95% confidence interval 0·32–2·77). This result was confirmed by the linear regression model. Our study does not find any association between the presence of smallpox vaccine scar and the β2m level and does not support any association between a previous smallpox vaccination and HIV disease progression. In this study, IA is not a significant determinant of the reported non-targeted effect of smallpox vaccination in PLHIV.
Assembly-History Dynamics of a Pitcher-Plant Protozoan Community in Experimental Microcosms

Background History drives community assembly through differences both in density (density effects) and in the sequence in which species arrive (sequence effects). Density effects arise from predictable population dynamics, which are free of history, but sequence effects are due to a density-free mechanism, arising solely from the order and timing of immigration events. Few studies have determined how components of immigration history (timing, number of individuals, frequency) alter local dynamics to determine community assembly, beyond addressing when immigration history produces historically contingent assembly. Methods/Findings We varied density and sequence effects independently in a two-way factorial design to follow community assembly in a three-species aquatic protozoan community. A superior competitor, Colpoda steinii, mediated alternative community states; early arrival or high introduction density allowed this species to outcompete or suppress the other competitors (Poterioochromonas malhamensis and Eimeriidae gen. sp.). Multivariate analysis showed that density effects caused greater variation in community states, whereas sequence effects altered the mean community composition. Conclusions A significant interaction between density and sequence effects suggests that we should refine our understanding of priority effects. These results highlight a practical need to understand not only the “ingredients” (species) in ecological communities but their “recipes” as well.
Increasing Confidence and Ability in Implementing Kangaroo Mother Care Method Among Young Mothers

ABSTRACT Mothers giving birth to low birth weight babies (LBWBs) have low confidence in caring for their babies because they are often still young and may lack the knowledge, experience, and ability to care for the baby. This research aims to determine the effect of education about kangaroo mother care (KMC) on the confidence and ability of young mothers to implement KMC. The research methodology used was a controlled-random experimental approach with pre- and post-test equivalent groups of 13 mothers and their LBWBs in the intervention group and 13 mothers and their LBWBs in the control group. Data were collected via an instrument measuring young mothers’ confidence, the validity and reliability of which have been tested with a resulting r value of . 941, and an observation sheet on KMC implementation. After conducting the education, the confidence score of young mothers and their ability to perform KMC increased meaningfully. The score of confidence of young mothers before education was 37 (p = .1555: and the ability score for KMC Implementation before education was 9 (p = .1555). The median score of confidence of young mothers after education in the intervention group was 87 and in the control group was 50 (p = .001, 95% CI 60.36–75.56), and ability median score for KMC implementation after education in the intervention group was 16 and in the control group was 12 (p = .001, 95% CI 1.50–1.88). KMC education should be conducted gradually, and it is necessary to involve the family, in order for KMC implementation to continue at home. A family visit can be done for LBWBs to evaluate the ability of the young mothers to implement KMC.
Mechanical and Microstructural Characterization of Thermal Spray Coating

Chromium carbide nickel chrome, Cr3C2-25NiCr coatings applied onto AISI E4340 alloy steel through high velocity oxy-fuel (HVOF) is studied in order to know its mechanical and microstructural characteristics. Specimens were prepared and microhardness tests were carried out to obtain the hardness value of the coatings when compared to the substrate, microhardness of the coatings found to be of 843 HV. The porosity of the coatings as analyzed according to ASTM E2109 and found to be around 0.93%. It is found that HVOF sprayed Cr3C2-25NiCr produced a better coatings than other types of thermal spray process as compared with previous studies by other researchers.
On recycled carbon fibre composites manufactured through a liquid composite moulding process

The recovery of carbon fibres from waste and end-of-life carbon fibre reinforced plastic materials is both economically lucrative and environmentally necessary. Here, we characterise the physical and mechanical properties of recycled carbon fibre reinforced plastics (rCFRPs) composed of random and oriented non-woven recycled carbon fibre mats that were impregnated with liquid epoxy matrices using a vacuum-infusion set-up. The low areal density and poor compactability of the non-woven mats implied that press-moulding upon impregnation was essential to control laminate thickness and improve fibre content; this may limit the applications of the resulting rCFRPs. Moreover, the press consolidation process is thought to degrade fibre length, and is a likely cause for the lower-than-expected tensile properties of the rCFRPs. Expectedly, the oriented rCFRPs exhibited better tensile and compressive properties than the random rCFRPs. Notably, while the tensile strength of the rCFRPs was only up to 2.5 times better than the matrix, the tensile modulus was 4–10 times enhanced. Through a comparative literature survey, we found that the liquid composite moulded rCFRPs were outperformed by rCFRPs fabricated through other manufacturing processes (e.g. prepregging), particularly those employing high compaction pressures, and utilising long fibres recovered through pyrolysis and chemical processes, rather than the fluidised-bed process.