Miracle-dz/UniFAR-FTUs huggingface dataset:
The neuropsychology of delirium: advancing the science of delirium assessment

The diagnosis of delirium depends on eliciting its features through mental status examination and informant history. However, there is marked heterogeneity in how these features are assessed, from binary subjective clinical judgement to more comprehensive methods supported by cognitive testing. The aim of this article is to review the neuropsychological research in delirium and suggest future directions in research and clinical practice.
Constraints on Asian ozone using Aura TES, OMI and Terra MOPITT

Abstract. Rapid industrialization in Asia in the last two decades has resulted in a significant increase in Asian ozone (O3) precursor emissions with likely a corresponding increase in the export of O3 and its precursors. However, the relationship between this increasing O3, the chemical environment, O3 production efficiency, and the partitioning between anthropogenic and natural precursors is unclear. In this work, we use satellite measurements of O3, CO and NO2 from TES (Tropospheric Emission Spectrometer), MOPITT (Measurement of Pollution In The Troposphere) and OMI (Ozone Monitoring Instrument) to quantify O3 precursor emissions for 2006 and their impact on free tropospheric O3 over northeastern Asia, where pollution is typically exported globally due to strong westerlies. Using the GEOS-Chem (Goddard Earth Observing System Chemistry) global chemical transport model, we test the modeled seasonal and interannual variation of O3 based on prior and updated O3 precursor emissions where the updated emissions of CO and NOx are based on satellite measurements of CO and NO2. We show that the observed TES O3 variability and amount are consistent with the model for these updated emissions. However, there is little difference in the modeled ozone between the updated and prior emissions. For example, for the 2006 June time period, the prior and posterior NOx emissions were 14% different over China but the modeled ozone in the free troposphere was only 2.5% different. Using the adjoint of GEOS-Chem we partition the relative contributions of natural and anthropogenic sources to free troposphere O3 in this region. We find that the influence of lightning NOx in the summer is comparable to the contribution from surface emissions but smaller for other seasons. China is the primary contributor of anthropogenic CO, emissions and their export during the summer. While the posterior CO emissions improved the comparison between model and TES by 32%, on average, this change also had only a small effect on the free tropospheric ozone. Our results show that the influence of India and southeastern Asia emissions on O3 pollution export to the northwestern Pacific is sizeable, comparable with Chinese emissions in winter, about 50% of Chinese emissions in spring and fall, and approximately 20% of the emissions in the summer.
Welfare reform and the street level bureaucrat in homelessness services

Purpose – Lipsky’s street level bureaucrat conceptual framework is employed to assist in understanding the ways in which statutory frontline homelessness practitioners are engaging with the current welfare reform agenda. The paper aims to discuss these issues. Design/methodology/approach – Draws the street level bureaucrat framework. A national baseline survey of homelessness practitioners was followed by targeted qualitative interviews involving 12 local authorities in England. Findings – Homelessness practitioners are facing a twofold crisis due to an increase in service users and corresponding decrease in feasible housing options or resources to tackle this. It was reported that effective service provision for all who required it was becoming increasingly difficult, which in turn fostered an environment in which unlawful gatekeeping practices could thrive. Further, it was found that a service user’s position may be additionally weakened due to the new powers conferred in the Localism Act. Research limi.
Discovering sparse transcription factor codes for cell states and state transitions during development

Computational analysis of gene expression to determine both the sequence of lineage choices made by multipotent cells and to identify the genes influencing these decisions is challenging. Here we discover a pattern in the expression levels of a sparse subset of genes among cell types in B- and T-cell developmental lineages that correlates with developmental topologies. We develop a statistical framework using this pattern to simultaneously infer lineage transitions and the genes that determine these relationships. We use this technique to reconstruct the early hematopoietic and intestinal developmental trees. We extend this framework to analyze single-cell RNA-seq data from early human cortical development, inferring a neocortical-hindbrain split in early progenitor cells and the key genes that could control this lineage decision. Our work allows us to simultaneously infer both the identity and lineage of cell types as well as a small set of key genes whose expression patterns reflect these relationships. DOI: http://dx.doi. org/10.7554/eLife.20488. 001
Effect of channel blockers on potassium efflux from metabolically exhausted frog skeletal muscle.

1. 86Rb and 42K have been used to assess potassium exchange in frog skeletal muscle which had been metabolically exhausted by electrical stimulation (1 Hz) after treatment with 2 mM‐cyanide and 1 mM‐iodoacetate. These conditions led to the development of rigor. 2. Poisoning by itself induced a small but variable increase in tracer efflux. Complete mechanical exhaustion subsequent to electrical stimulation was, however, accompanied by a 5‐6 fold increase in the rate coefficient for both 86Rb and 42K efflux. In the case of rubidium this was maintained for at least 20 min and often for up to 1 h. 3. The increase in tracer efflux induced by metabolic exhaustion was inhibited by barium (0.03‐5 mM) in a reversible and concentration‐dependent manner. Inhibition was also observed with glibenclamide (3‐100 microM), tolbutamide (0.3‐2 mM), TEA (5‐100 mM) and the local anaesthetics lignocaine (1‐3 mM) and tetracaine (1 mM). Quinine produced a dual response consisting of an inhibitory component which was most clearly seen at low concentrations (0.3 mM) and an enhancement of tracer efflux that became increasingly dominant at higher concentrations (1‐10 mM). 4. Both apamin (30 and 100 nM) and Israeli scorpion (Leiurus quinquestriatus) venom (16 micrograms ml‐1) produced little or no block of the tracer efflux activated by metabolic exhaustion. Similarly 4‐aminopyridine (3 mM) and decamethonium (0.3 mM) were without obvious effect. 5. It is concluded that metabolic exhaustion of frog skeletal muscle leads to an increased permeability to both 42K and 86Rb. Our results with channel blockers suggest that this K+ permeability can be attributed neither to the delayed rectifier nor to an apamin‐ or charybdotoxin‐sensitive calcium‐activated K+ permeability (PK(Ca) but may be predominantly due to activation of ATP‐sensitive channels similar to those found in the beta‐cells of pancreatic islets.
Generational differences in personality and motivation: Do they exist and what are the implications for the workplace?

Purpose – The purpose of this research is to examine whether personality and motivational driver differences exist across three generations of working Australians: Baby Boomers, Gen Xs, and Gen Ys.Design/methodology/approach – Using the Occupational Personality Questionnaire and the Motivation Questionnaire, the study examined cross‐sectional differences in personality and motivational drivers across three generations.Findings – The results are not supportive of the generational stereotypes that have been pervasive in the management literature and the media. Specifically, few meaningful differences were found between the three generations. Moreover, even when differences have been observed, these have related more to age than generation.Research limitations/implications – One of the key limitations is the use of cross‐sectional data. To further explore this issue, it would be interesting to undertake a longitudinal study to assess personality preferences and motivational drivers of the different generatio.
Wavelet families of increasing order in arbitrary dimensions

We build discrete-time compactly supported biorthogonal wavelets and perfect reconstruction filter banks for any lattice in any dimension with any number of primal and dual vanishing moments. The associated scaling functions are interpolating. Our construction relies on the lifting scheme and inherits all of its advantages: fast transform, in-place calculation, and integer-to-integer transforms. We show that two lifting steps suffice: predict and update. The predict step can be built using multivariate polynomial interpolation, while update is a multiple of the adjoint of predict. While we concentrate on the discrete-time case, some discussion of convergence and stability issues together with examples is given.
Expression of homologous RND efflux pump genes is dependent upon AcrB expression: implications for efflux and virulence inhibitor design

Objectives Enterobacteriaceae have multiple efflux pumps that confer intrinsic resistance to antibiotics. AcrB mediates clinically relevant multidrug resistance and is required for virulence and biofilm formation, making it an attractive target for the design of inhibitors. The aim of this study was to assess the viability of single transporters as a target for efflux inhibition using Salmonella Typhimurium as the model pathogen. Methods The expression of resistance–nodulation–division (RND) efflux pump genes in response to the inactivation of single or multiple homologues was measured using real-time RT–PCR. Phenotypes of mutants were characterized by measuring antimicrobial susceptibility, dye accumulation and the ability to cause infection in vitro. Results The expression of all RND efflux pump genes was increased when single or multiple acr genes were inactivated, suggesting a feedback mechanism that activates the transcription of homologous efflux pump genes. When two or three acr genes were inactivated, the mutants had further reduced efflux, altered susceptibility to antimicrobials (including increased susceptibility to some, but conversely and counterintuitively, decreased susceptibility to some others) and were more attenuated in the tissue culture model than mutants lacking single pumps were. Conclusions These data indicate that it is critical to understand which pumps an inhibitor is active against and the effect of this on the expression of homologous systems. For some antimicrobials, an inhibitor with activity against multiple pumps will have a greater impact on susceptibility, but an unintended consequence of this may be decreased susceptibility to other drugs, such as aminoglycosides.
The impact of social pressures, locus of control, and professional commitment on auditors’ judgment: Indonesian evidence

Purpose - The purpose of this paper is to investigate the impact of improper social pressures on auditors’ judgment in the setting of a high power distance and low individualism society. Auditors’ judgment in this paper is related to the case of auditors’ willingness to sign off on net equipment balance for assets in question. Second, the paper investigates the role of locus of control and the relationship of multidimensional professional commitment on auditors’ judgment under conditions of social pressure. Design/methodology/approach - The experimental method is used in this research. The paper uses a case that was developed by Lord and DeZoort to manipulate the interest variable, social pressures. The paper also uses locus of control and multidimensional professional commitment as the explanatory variables. Findings - The research finds that social pressures affect auditors’ judgment in a high power distance and low individualism society. Auditors who contend with improper social pressures make judgments that violate their integrity and professionalism. The paper also finds that locus of control and multidimensionality of professional commitment might potentially affect auditors’ judgment. Originality/value - The research takes into account cultural influence on auditors’ judgment. The paper uses subjects who are in a high power distance and low individualism society. As Public Accountant is a worldwide profession, it is important to understand the impact of cultural dimensions on the profession. Moreover, insights drawn from this paper may be of assistance to regulators and the public accountant profession in considering and developing a mechanism that can mitigate the impact of improper social pressures.
Escalating protein doses of chimeric monoclonal antibody MOv18 immunoglobulin G in ovarian carcinoma patients: A phase I study

Successful first‐line treatment of ovarian cancer does not incite cure. Recurrent disease often shows an increased resistance to chemotherapeutic agents. Therefore, other treatment modalities, like (radio)immunotherapy using tumor‐associated monoclonal antibodies, should be considered. Chimeric MOv18 (c‐MOv18) localizes well in ovarian carcinoma tissue. We investigated the safety of a single intravenous (i.v.) infusion of increasing doses of c‐MOv18 in ovarian carcinoma patients.
Function modeling using the system state flow diagram

Abstract This paper introduces a rigorous framework for function modeling of complex multidisciplinary systems based on the system state flow diagram (SSFD). The work addresses the need for a consistent methodology to support solution-neutral function-based system decomposition analysis, facilitating the design, modeling, and analysis of complex systems architectures. A rigorous basis for the SSFD is established by defining conventions for states and function definitions and a representation scheme, underpinned by a critical review of existing literature. A set of heuristics are introduced to support the function decomposition analysis and to facilitate the deployment of the methodology with strong practitioner guidelines. The SSFD heuristics extend the existing framework of Otto and Wood (2001) by introducing a conditional fork node heuristic, to facilitate analysis and aggregation of function models across multiple modes of operation of the system. The empirical validation of the SSFD function modeling framework is discussed in relation to its application to two case studies: a benchmark problem (glue gun) set for the engineering design community; and an industrial case study of an electric vehicle powertrain. Based on the evidence from the two case studies presented in the paper, a critical evaluation of the SSFD function modeling methodology is discussed based on the function benchmarking framework established by Summers et al. (2013), considering the representation, modeling, cognitive, and reasoning characteristics. The significance of this paper is that it establishes a rigorous reference framework for the SSFD function representation and a consistent methodology to guide the practitioner with its deployment, facilitating its impact to industrial practice.
Religiosity, adolescent Internet usage motives and addiction

Based on secularization theory, this paper analyzes religiosity's relationship with youths' Internet addiction tendencies via possible mediating Internet usage motivations (erotic, social, communication, entertainment and psychological escape). Using self-report questionnaire scales in a study of 1,596 Malaysian adolescent school students, a negative relationship between religiosity and Internet addiction tendency was found to be replicable for females across all four religions studied (Islam, Hinduism, Buddhism and Christianity). However, no such relationship was found for any of the corresponding male groups. This finding is discussed in terms of females being more likely than males to experience the spiritual element of religion and to adhere more to religious norms. The female religiosity – addiction relationship was found to be mediated by psychological escape motives for three of the four religious groups, and erotic motives for two of the groups. The former finding supports a previous claim that escape motives are a prime driver of Internet addictions. It is concluded that, via its prediction of religiosity's negative relationships with Internet usage, secularization theory plays a role in explaining lower likelihood of Internet addiction among more highly religious females, the finding being limited to females because of differing cross-gender socialization pressures.
Ideas and Debates in Family Law

Ideas and Debates in Family Law is written for family law students, at undergraduate level and beyond, who are looking for less orthodox ideas about family law. The book's first section looks at themes in family law, addressing challenges facing the family justice system, rights and responsibilities, and the internationalisation of the law regulating families. The second section is focused on adult relationships: it suggests new ways for the law to allocate legal consequences for families, debates the consequences of the 'contractualisation' of marriage, and explores the value of 'fairness' in family finances. The third section is about children, discussing the welfare principle, parental responsibility and practical parenting. Although these issues sound common enough in a family law book, the discussions found here are far from common. Useful by itself or alongside a textbook, Ideas and Debates in Family Law offers new and thought-provoking perspectives on family law issues.
The Interplay of Institutional Logics in it Public-Private Partnerships

Public-private partnerships (PPPs) offer a popular means by which the public sector can obtain infor-mation technology (IT) innovations and management know-how from private firms. However, these IT PPPs are extremely difficult to realize, especially considering the divergent interests of public- and private-side stake-holders. Our case study of an IT PPP reveals public- and private-side differences that initially impeded the establishment of a partnership; using institutional logics theory as meta-theoretical lens, we propose a model that explains how public and private parties managed to negotiate their mode of collaboration by balancing their competing institutional norms and practices which ultimately resulted in the convergence of the two divergent logics. Our paper contributes to theory and practice by (1) elucidating the theoretical foundations and role of institutional logics for IT project management that we found dominated by public and private norms and practices, (2) explaining why collaboration in IT PPPs is so diffi-cult, and (3) how eventually an IT PPP can be estab-lished. We discuss theoretical and practical implica-tions in the paper.
Modeling uncertainties in publish/subscribe systems

In the publish/subscribe paradigm, information providers disseminate publications to all consumers who have expressed interest by registering subscriptions. This paradigm has found wide-spread applications, ranging from selective information dissemination to network management. However, all existing publish/subscribe systems cannot capture uncertainty inherent to the information in either subscriptions or publications. In many situations, exact knowledge of either specific subscriptions or publications is not available. Moreover, especially in selective information dissemination applications, it is often more appropriate for a user to formulate her search requests or information offers in less precise terms, rather than defining a sharp limit. To address these problems, this paper proposes a new publish/subscribe model based on possibility theory and fuzzy set theory to process uncertainties for both subscriptions and publications. Furthermore, an approximate publish/subscribe matching problem is defined and algorithms for solving it are developed and evaluated.
Down with the bureaucracy of syntax ! Pattern matching for classical linear logic

This paper introduces a new way of attaching proof terms to proof trees for classical linear logic, which bears a close resemblance to the way that pattern matching is used in programming languages. It equates the same proofs that are equated by proof nets, in the formulation of proof nets introduced by Dominic Hughes and Rob van Glabbeek; and goes beyond that formulation in handling exponentials and units. It provides a symmetric treatment of all the connectives, and may provide programmers with improved insight into connectives such as “par” and “why not” that are difficult to treat in programming languages based on an intuitionistic formulation of linear logic. This paper uses colour to enhance its presentation. If the URL below is not blue, follow it for the colour version. http://homepages.inf. ed.ac. uk/wadler
Teaching About Sexuality

Abstract Human sexuality is taught in a number of public middle and high schools within the United States. Teachers report less professional preparation and training in this area and difficulties associated with teaching what is considered to be a sensitive subject. In the current paper, we review the nature by which sexuality education is positioned within school systems. With the goal of providing support to front-line teachers and professionals-in-training, we then discuss how the professional standards from various disciplines support both the inclusion of sexuality education and those who teach it. We suggest that providing support for human sexuality teachers may be found from the professional associations they develop with other sexuality teachers. To that end, we encourage sexuality professionals to bridge relationships with teachers who seek professional resources and personal encouragement from sexuality scientists and educators.
Targeting Surface Protein SasX by Active and Passive Vaccination To Reduce Staphylococcus aureus Colonization and Infection

ABSTRACT SasX is a recently described surface protein of Staphylococcus aureus that is linked to the epidemic success of hospital-associated methicillin-resistant clones, in particular in Asia. It enhances nasal colonization and virulence in skin and lung infection models. Here, we evaluated the potential of SasX as a vaccine component in passive and active immunization efforts using mouse infection models. We found that SasX induced a specific immune response predominantly based on IgG1 antibodies. Active immunization with recombinant SasX or passive immunization with rabbit polyclonal anti-SasX IgG significantly decreased the size of lesions caused by S. aureus in a skin infection model. Furthermore, active immunization reduced acute lung injury in a lung infection model. Moreover, active or passive immunization significantly reduced S. aureus colonization in a nasal colonization model. Finally, anti-SasX IgG enhanced the susceptibility of S. aureus to killing by human neutrophils. We conclude that SasX is a potential target for therapeutics or vaccines designed to moderate colonization and infection by sasX-positive epidemic strains of S. aureus.
WebQuests for Reflection and Conceptual Change: Variations on a Popular Model for Guided Inquiry.

WebQuests have become a popular form of guided inquiry using Web resources. The goal of WebQuests is to help students think and reason at higher levels,and use information to solve problems. This paper presents modifications to the WebQuest model drawing on primarily on schema theory. It is believed that these changes will further enhance student reflection and deepen conceptual change through the use of WebQuest activities in the classroom. The revised model is illustrated in a makeover of a sample WebQuest. Includes two figures. (Contains 12 references.) (Author) Reproductions supplied by EDRS are the best that can be made from the original document. Web Quests for Reflection and Conceptual Change: Variations on a Popular Model for Guided Inquiry PERMISSION TO REPRODUCE AND DISSEMINATE THIS MATERIAL HAS BEEN GRANTED BY