Miracle-dz/UniFAR-FTUs huggingface dataset:
A multi-perspective concept mapping study of problems associated with traumatic brain injury

Objective: To develop a model of the problems of persons with traumatic brain injury that includes multiple perspectives as well as the multi-dimensional nature of the phenomena. Design: Concept mapping, a multi-variate modelling strategy, was employed to produce an exhaustive inventory and concept map of TBI-related problems based on input from patients, family caregivers and professional providers. Results: The eight-cluster concept map included the following dimensions: social competence, intimacy, behavioural, maturity/independence, neurophysiological, mood, executive functions and non-executive functions. Conclusions: An underlying two-dimensional conceptual model of TBI problems is proposed with relevance for theory, practice and further research.
Properties of analog systems with varying parameters [averaging/low-pass filters]

This paper examines the properties of solutions to ordinary differential equations from the point of view of their applications as averaging and low-pass filters. The stationarity of solutions to systems with varying parameters was analyzed together with stability conditions of these systems by making use of the theorem on stability of nonhomogeneous systems when the corresponding homogeneous systems were stable. The transient state was analyzed and the possibility of its shortening was shown. The performed simulations of the variable parameter Butterworth, Legendre and Chebyshev low-pass filters of the 2-nd up to the 6-th order proved the usefulness of the method.
An explanation for conflicting records of Triassic–Jurassic plant diversity

Macrofossils (mostly leaves) and sporomorphs (pollen and spores) preserve conflicting records of plant biodiversity during the end-Permian (P-Tr), Triassic–Jurassic (Tr-J), and end-Cretaceous (K-T) mass extinctions. Estimates of diversity loss based on macrofossils are typically much higher than estimates of diversity loss based on sporomorphs. Macrofossils from the Tr-J of East Greenland indicate that standing species richness declined by as much as 85% in the Late Triassic, whereas sporomorph records from the same region, and from elsewhere in Europe, reveal little evidence of such catastrophic diversity loss. To understand this major discrepancy, we have used a new high-resolution dataset of sporomorph assemblages from Astartekløft, East Greenland, to directly compare the macrofossil and sporomorph records of Tr-J plant biodiversity. Our results show that sporomorph assemblages from the Tr-J boundary interval are 10–12% less taxonomically diverse than sporomorph assemblages from the Late Triassic, and that vegetation composition changed rapidly in the boundary interval as a result of emigration and/or extirpation of taxa rather than immigration and/or origination of taxa. An analysis of the representation of different plant groups in the macrofossil and sporomorph records at Astartekløft reveals that reproductively specialized plants, including cycads, bennettites and the seed-fern Lepidopteris are almost absent from the sporomorph record. These results provide a means of reconciling the macrofossil and sporomorph records of Tr-J vegetation change, and may help to understand vegetation change during the P-Tr and K-T mass extinctions and around the Paleocene–Eocene Thermal Maximum.
Stent Longitudinal Strength Assessed Using Point Compression: Insights From a Second-Generation, Clinically Related Bench Test

Background—Stent longitudinal distortion, while infrequent, can lead to adverse clinical events. Our first bench comparison of susceptibility of different stent designs to distortion applied force to the entire circumference of the proximal stent hoop. The test increased understanding of stent design and led to recommendations for design change in some. Our second-generation test more closely mimics clinical scenarios by applying force to a point on the proximal hoop of a malapposed stent. Methods and Results—Each 3-mm-diameter stent was secured in a test apparatus so that its proximal 5 mm was malapposed in a 3.5-mm tube. An instron applied force to the proximal hoop of each of 5 examples of each of 6 stent designs using a narrow rod so that force applied and distance compressed could be measured. Hoops on the side of the force were pushed together, became malapposed, and obstructed the lumen. In addition, the proximal stent hoop tilted causing malapposition, the contralateral side of the stent from the applied force causing lumen obstruction. Conclusions—This second-generation, more clinically relevant test showed the Biomatrix Flex was the most resistant to deformation and the Element the most easily deformed. The addition of more connectors between the proximal hoops in the Promus Premier design has reduced the potential for distortion when compared with the Element, so that distortion was similar to the Vision, Multi-Link 8, and Integrity designs. The test also provided insight into the way in which stents are likely to distort in clinical practice.
Antibacterial Activity of Copper-doped Montmorillonite Nanocomposites Prepared by Alkaline Ion Exchange Method

The antibacterial activity of copper-doped montmorillonite nanocomposites (Cu-MMT) has been investigated. Copper loaded clay nanocomposites have been synthesised by alkaline ion exchange processes in media containing copper sulfate at 550°C. Characterisation studies on the composites were done by X-ray diffractometry (XRD), scanning electron microscope (SEM) and absorption spectra analysis. SEM results indicated the diffusion of copper to the inner montmorillonite layer and opening of presenting cracks on its surface. The XRD analysis showed the presence of copper oxide (CuO) structure intercalated within the clay mineral layers. The antimicrobial effects of doped montmorillonite powders against pathogen bacterial strains Escherichia coli and Staphylococcus aureus were tested in broth media. Quantitative test in liquid media clearly showed that copper-doped samples had viable cells reduction ability for testing strains. The excellent antimicrobial activity of the composites was observed on S. aureus. In addition, the composite showed good stability in water and good promise for use in water treatment.
Intravenous Treatment With Ibandronate Normalizes Bone Matrix Mineralization and Reduces Cortical Porosity After Two Years in Male Osteoporosis: A Paired Biopsy Study

The spectrum of therapeutic options and the amount of clinical trials for male osteoporosis (mOP) is lower than those for postmenopausal osteoporosis. Therefore, we examined the effects of 24 months of ibandronate (IBN) treatment (3 mg/3 mL intravenously every 3 months) on bone material quality in 19 subjects with mOP within an open‐label, single‐center, prospective phase III study (Eudract number 2006‐006692‐20). Patients (median age [25th, 75th percentiles] 53.0 [44.5; 57.0] years) were included if they had low bone mineral density (BMD) and/or at least one low trauma fracture and no secondary cause of osteoporosis. The primary endpoint was to evaluate IBN effects on cancellous (Cn.) and cortical (Ct.) bone mineralization density distribution (BMDD) based on quantitative backscattered electron imaging (qBEI) of paired transiliacal bone biopsies (baseline, 24 months). Secondary endpoints included changes in areal bone mineral density (BMD by dual‐energy X‐ray absorptiometry [DXA]) and serum markers of bone turnover including type I collagen peptides CrossLaps (CTX), procollagen type 1 amino‐terminal propeptide (P1NP), and osteocalcin (OC). At baseline, cancellous bone matrix mineralization from mOP was lower than published reference data (mean degree of mineralization Cn.CaMean −1.8%, p < 0.01). IBN treatment increased calcium concentrations versus baseline (Cn.CaMean +2.4%, Ct.CaMean, +3.0% both p < 0.01), and reduced heterogeneity of mineralization (Cn.CaWidth −14%, p = 0.044; Ct.CaWidth, −16%, p = 0.001), leading to cancellous BMDD within normal range. IBN treatment was associated with a decrease in porosity of mineralized cortical tissue (−25%, p = 0.01); increases in BMD at the lumbar spine, the femoral neck, and the total hip (+3.3%, +1.9%, and +5.6%, respectively, p ≤ 0.01); and reductions in CTX (−37.5%), P1NP (−44.4%), and OC (−36.3%, all p < 0.01). Our BMDD findings are in line with the reduction of bone turnover markers and the increase in BMD by IBN in our patients and suggest that the latter mainly reflects the increase in matrix mineralization and the reduction of cortical porosity in this cohort with mOP. © 2014 American Society for Bone and Mineral Research.
Single-Link Failure Detection in All-Optical Networks Using Monitoring Cycles and Paths

In this paper, we consider the problem of fault localization in all-optical networks. We introduce the concept of monitoring cycles (MCs) and monitoring paths (MPs) for unique identification of single-link failures. MCs and MPs are required to pass through one or more monitoring locations. They are constructed such that any single-link failure results in the failure of a unique combination of MCs and MPs that pass through the monitoring location(s). For a network with only one monitoring location, we prove that three-edge connectivity is a necessary and sufficient condition for constructing MCs that uniquely identify any single-link failure in the network. For this case, we formulate the problem of constructing MCs as an integer linear program (ILP). We also develop heuristic approaches for constructing MCs in the presence of one or more monitoring locations. For an arbitrary network (not necessarily three-edge connected), we describe a fault localization technique that uses both MPs and MCs and that employs multiple monitoring locations. We also provide a linear-time algorithm to compute the minimum number of required monitoring locations. Through extensive simulations, we demonstrate the effectiveness of the proposed monitoring technique.
Chronic Psychosocial Stress Impairs Bone Homeostasis: A Study in the Social Isolation Reared Rat

Chronic psychosocial stress is a key player in the onset and aggravation of mental diseases, including psychosis. Although a strong association between this psychiatric condition and other medical co-morbidities has been recently demonstrated, few data on the link between psychosis and bone homeostasis are actually available. The aim of this study was to investigate whether chronic psychosocial stress induced by 4 or 7 weeks of social isolation in drug-naïve male Wistar rats could alter bone homeostasis in terms of bone thickness, mineral density and content, as well as markers of bone formation and resorption (sclerostin, cathepsin K, and CTX-I). We found that bone mineral density was increased in rats exposed to 7 weeks of social isolation, while no differences were detected in bone mineral content and area. Moreover, 7 weeks of social isolation lead to increase of femur thickness with respect to controls, suggesting the development of a hyperostosis condition. Isolated rats showed no changes in sclerostin levels, a marker of bone formation, compared to grouped animals. Conversely, bone resorption markers were significantly altered after 7 weeks of social isolation in terms of decrease in cathepsin K and increase of CTX-I. No alterations were found after 4 weeks of isolation rearing. Our observations suggest that chronic psychosocial stress might affect bone homeostasis, more likely independently from drug treatment. Thus, the social isolation model might help to identify possible new therapeutic targets to treat the burden of chronic psychosocial stress and to attempt alternative therapy choices.
Unbinding and unfolding of adhesion protein complexes through stretching: Interplay between shear and tensile mechanical clamps

Using coarse‐grained molecular dynamics simulations, we analyze mechanically induced dissociation and unfolding of the protein complex CD48‐2B4. This heterodimer is an indispensable component of the immunological system: 2B4 is a receptor on natural killer cells whereas CD48 is expressed on surfaces of various immune cells. So far, its mechanostability has not been assessed either experimentally or theoretically. We find that the dissociation processes strongly depend on the direction of pulling and may take place in several pathways. Interestingly, the CD48‐2B4 interface can be divided into three distinct patches that act as units when resisting the pulling forces. At experimentally accessible pulling speeds, the characteristic mechanostability forces are in the range between 100 and 200 pN, depending on the pulling direction. These characteristic forces need not be associated with tensile forces involved in the act of separation of the complex because prior shear‐involving unraveling within individual proteins may give rise to a higher force peak. Proteins 2014; 82:3144–3153. © 2014 Wiley Periodicals, Inc.
Inter-Comparison and Synergy Between the Two Long-Term Global Aerosol Products Derived from AVHRR and TOMS

Eighteen years of satellite-based monthly aerosol products have been derived from the advanced very high resolution radiometer (AVHRR) and total ozone mapping experiment spectrometer (TOMS) sensors. The two products differ in many regards rendering a great potential for developing an integrated product for climate studies. Presented here are some preliminary results of inter-comparison and synergy analyses.
Sex differences in number line estimation: The role of numerical estimation

Sex differences in mathematical performance have frequently been examined over the last decades indicating an advantage for males especially when numerical problems cannot be solved by (classroom-)learnt strategies and/or estimation. Even in basic numerical tasks such as number line estimation, males were found to outperform females - with sex differences argued to emerge from different solution strategies applied by males and females. We evaluated the latter using two versions of the number line estimation task: a bounded and an unbounded task version. Assuming that women tend more strongly to apply known procedures, we expected them to be at a particular disadvantage in the unbounded number line estimation task, which is less prone to be solved by specific strategies such as proportion judgement but requires numerical estimation. Results confirmed more pronounced sex differences for unbounded number line estimation with males performing significantly more accurately in this task version. This further adds to recent evidence suggesting that estimation performance in the bounded task version may reflect solution strategies rather than numerical estimation. Additionally, it indicates that sex differences regarding the spatial representation of number magnitude may not be universal, but associated with spatial-numerical estimations in particular.
Emotion-recognition abilities and behavior problem dimensions in preschoolers: Evidence for a specific role for childhood hyperactivity

Facial emotion-recognition difficulties have been reported in school-aged children with behavior problems; little is known, however, about either this association in preschool children or with regard to vocal emotion recognition. The current study explored the association between facial and vocal emotion recognition and behavior problems in a sample of 3 to 6-year-old children. A sample of 57 children enriched for risk of behavior problems (41 were recruited from the general population while 16 had been referred for behavior problems to local clinics) were each presented with a series of vocal and facial stimuli expressing different emotions (i.e., angry, happy, and sad) of low and high intensity. Parents rated children’s externalizing and internalizing behavior problems. Vocal and facial emotion recognition accuracy was negatively correlated with externalizing but not internalizing behavior problems independent of emotion type. The effects with the externalizing domain were independently associated with hyperactivity rather than conduct problems. The results highlight the importance of using vocal as well as facial stimuli when studying the relationship between emotion-recognition and behavior problems. Future studies should test the hypothesis that difficulties in responding to adult instructions and commands seen in children with attention deficit/hyperactivity disorder (ADHD) may be due to deficits in the processing of vocal emotions.
Dynamic gain scheduled control in a multi-variable control framework

A controller designed for linearizations at various trim/operating points of a nonlinear system using linear approaches is not necessarily well-performing or stable once scheduled with a state to retain the scheduled control law design close to the current operating point. Dynamic gain scheduling (DGS) is a technique aimed to resolve this controller scheduling issue for rapidly changing dynamics and states. It entails scheduling the control law gains with a fast varying state variable rather than with a slowly varying state. It has been applied to aircraft system models successfully in a single-input-single-output fashion, allowing also for nested loops. The aim of this paper is to extend dynamic gain scheduling to general multi-variable nonlinear control systems. Given a linear design, suitable transformations are provided which allow fast scheduling of multi-variable controllers. Theoretical results are shown, providing important parallels to nonlinear dynamic inversion control. Several examples are presented in order to emphasize the characteristics of DGS. Comparative results of dynamic gain scheduling in relation to two other gain scheduling approaches show significant advantages when controlling highly nonlinear systems.
Complementary observational constraints on climate sensitivity

A persistent feature of empirical climate sensitivity estimates is their heavy tailed probability distribution indicating a sizeable probability of high sensitivities. Previous studies make general claims that this upper heavy tail is an unavoidable feature of (i) the Earth system, or of (ii) limitations in our observational capabilities. Here we show that reducing the uncertainty about (i) oceanic heat uptake and (ii) aerosol climate forcing can—in principle—cut off this heavy upper tail of climate sensitivity estimates. Observations of oceanic heat uptake result in a negatively correlated joint likelihood function of climate sensitivity and ocean vertical diffusivity. This correlation is opposite to the positive correlation resulting from observations of surface air temperatures. As a result, the two observational constraints can rule out complementary regions in the climate sensitivity‐vertical diffusivity space, and cut off the heavy upper tail of the marginal climate sensitivity estimate.
A New Global Storage‐Area‐Depth Data Set for Modeling Reservoirs in Land Surface and Earth System Models

Reservoir storage‐area‐depth relationships are the most important factors controlling thermal stratification in reservoirs and, more broadly, the water, energy, and biogeochemical dynamics in the reservoirs and subsequently their impacts on downstream rivers. However, most land surface or Earth system models do not account for the gradual changes of reservoir surface area and storage with the changing depth, inhibiting a consistent and accurate representation of mass, energy, and biogeochemical balances in reservoirs. Here we present a physically coherent parameterization of reservoir storage‐area‐depth data set at the global scale. For each reservoir, the storage‐area‐depth relationships were derived from an optimal geometric shape selected iteratively from five possible regular geometric shapes that minimize the error of total storage and surface area estimation. We applied this algorithm to over 6,800 reservoirs included in the Global Reservoir and Dam database. The relative error between the estimated and observed total storage is no more than 5% and 50% for 66% and 99% of all Global Reservoir and Dam reservoirs, respectively. More importantly, the storage‐depth profiles derived from the approximated reservoir geometry compared well with remote sensing based estimation at 40 major reservoirs from previous studies and ground‐truth measurements for 34 reservoirs in the United States and China. The new global reservoir storage‐area‐depth data set is critical for advancing future modeling and understanding of reservoir processes and subsequent effects on the terrestrial hydrological, ecological, and biogeochemical cycles at the regional and global scales.
Sleep hypoxia in myotonic dystrophy and its correlation with awake respiratory function.

BACKGROUND--Tiredness and daytime respiratory failure occur frequently in myotonic dystrophy. Sleep hypoxaemia was studied in 12 patients with myotonic dystrophy and correlations were sought with their daytime lung and respiratory muscle function. METHODS--All patients underwent overnight sleep studies, clinical assessment, measurement of flow-volume loops and carbon monoxide transfer factor, arterial blood gas analysis, and physiological assessment of both thoracic muscle function and upper airways obstruction. RESULTS--The mean nadir of oxygen saturation during sleep was 75% (95% confidence interval 69% to 81%). A mean of 3.4% of total sleep duration was spent at an oxygen saturation level below 85%. Five of the 12 patients had an apnoea index of > 5, the group mean apnoea/hypopnoea index being 15.8 events/sleep hour. The mean awake arterial oxygen tension (PaO2) was 10.7 kPa. There was a trend to hypercapnoea with a mean awake arterial carbon dioxide tension of 6.1 kPa; carbon dioxide retention worsened during sleep. Respiratory muscle dysfunction was mainly evident as a low maximum expiratory mouth pressure. Upper airway obstruction assessed by physiological criteria was found in four of the 12 patients. The proportion of total sleep duration with oxygen saturation levels below 85% was directly related to body mass index (weight/height2) and inversely related to the awake PaO2. Body mass index was inversely related to the overnight nadir of oxygen saturation. CONCLUSIONS--Patients with myotonic dystrophy are often hypoxic during sleep and the subgroup that are obese, or have symptoms of sleep apnoea, or both, are particularly at risk. Sleep studies should be considered in this subgroup of patients with myotonic dystrophy.
A Two-Hop Solution to Solving Topology Mismatch

The efficiency of peer-to-peer (P2P) systems is largely dependent on the overlay constructions. Due to the random selection of logical neighbors, there is serious topology mismatch problem between the overlay and the physical topologies in many P2P systems. Such mismatching causes unnecessary query message duplications on both overlay and IP level, as well as increase query response time. In this research, we define the optimal overlay problem, and prove its NP-hardness. To address this issue, we propose a distributed overlay optimization algorithm, THANCS, and evaluate its effectiveness through trace driven simulations. The proposed THANCS has four major strengths. First, it does not need any global knowledge. Second, its optimization convergent speed is fast. Third, it is orthogonal to other types of advanced search approaches. Fourth, it reduces both the traffic cost and the search latency.