Miracle-dz/UniFAR-FTUs huggingface dataset:
TWO-YEAR OBSERVATION OF ARTIFICIAL INTERVERTEBRAL DISC REPLACEMENT USING SUPPLEMENTAL ULTRA HIGH STRENGTH BIORESORBABLE SPINAL STABILIZATION

Object. The two-year experimental study was conducted to investigate the efficacy of bioactive three-dimensional fabric disc (3-DF disc) for the lumbar intervertebral disc replacement. The study utilized the bioresorbable spinal fixation rod consisting of a forged composite of particulate unsintered hydroxyapatite/poly-L-lactide (u-HA/PLLA) for stability augmentation. The biomechanical and histologic alterations as well as possible device loosening were examined at two years postoperatively. Methods. Two lumbar discs of L2/3 and L4/5 were replaced with 3-DF discs, which were augmented by two titanium screws and a spanning bioresorbable rod (HA/PLLA). The segmental biomechanics and interface bone ingrowth were investigated at six, fifteen, and twenty-four months postoperatively, when comparing with other two surgical groups of 3-DF disc alone and additional stabilization with anterior instrumentation. The replaced spinal segments with 3-DF disc augmented by bioresorbable rod procured a segmental mobility at both 15 and 24 months, however, the range of motion (ROM) in flexion and extension decreased to 49% and 40%, respectively despite statistically equivalent torsional ROM preserved. The interface histology demonstrated the excellent bony fusion between fabric surface and vertebral body. Until two-year period, no adverse tissue reaction and aseptic loosening of the device were observed.
Kidney-Paired Donation to Increase Living Donor Kidney Transplantation in India: Guidelines of Indian Society of Organ Transplantation – 2017

Notice The Indian Society of Organ Transplantation clinical practice guideline document is designed to provide information and assist decision‐making in relation to kidney‐paired donation (KPD). It does not intend to define a standard of care. Variations in practice will inevitably occur when clinicians take into account the needs of individual patients, available resources, and limitations unique to a clinical situation. The working group acknowledged the lack of high‐quality evidence on the issue from India, on which to base our recommendations.
Effectiveness of mobile cooperation intervention on students’ clinical learning outcomes: A randomized controlled trial

AIMS The aim of this study was to evaluate the effectiveness of the mobile cooperation intervention in improving the competence and self-efficacy of students and the quality of the clinical learning environment. BACKGROUND For students, the clinical practicum is challenging as such and moreover the student - teacher cooperation, which supports the clinical learning of the students, has become complicated. Mobile applications have potential but their role in facilitating this cooperation remains unknown. DESIGN A parallel-group randomized controlled trial. METHODS Data were collected between January-March 2015 in Finland. The nursing students were randomly allocated to an intervention group (N = 52) or control group (N = 50). The intervention group used a mobile application to cooperate with the teacher during the clinical practicum. The control group engaged in standard cooperation. The primary outcome was competence. The secondary outcomes comprised self-efficacy and the quality of the clinical learning environment. Nurse Competence Scale, Self-efficacy in Clinical Performance instrument and the Clinical Learning Environment, Supervision and Nurse Teacher scale were used for student self-assessments. For the main analysis, hierarchical linear mixed models were used with the intention-to-treat principle. RESULTS Competence and self-efficacy showed no significant between-group differences in mean improvements, but significant improvements in both groups were detected over the 5 weeks. Satisfaction with the clinical learning environment showed no significant between-group differences, however, the role of the nurse teacher subscale, especially regarding cooperation, showed significant group differences. CONCLUSION The mobile cooperation intervention was not significantly effective in improving individual outcomes, but did seem to improve significantly some aspects of the contextual outcomes. TRIAL REGISTRATION NUMBER ClinicalTrials.gov: NCT02635295.
Long cycles through prescribed vertices have the Erdős‐Pósa property

We prove that for every graph, any vertex subset S, and given integers k,ℓ : there are k disjoint cycles of length at least ℓ that each contain at least one vertex from S, or a vertex set of size O(ℓ·klogk) that meets all such cycles. This generalizes previous results of Fiorini and Herinckx and of Pontecorvi and Wollan.
A comparison between minimized extracorporeal circuits and conventional extracorporeal circuits in patients undergoing aortic valve surgery: is ‘minimally invasive extracorporeal circulation’ just low prime or closed loop perfusion ?

Introduction: Even though results have been encouraging, an unequivocal conclusion on the beneficial effect of minimally invasive extracorporeal circulation (MiECC) in patients undergoing aortic valve surgery cannot be derived from previous publications. Long-term outcomes are rarely reported and a significant decrease in operative mortality has not been shown. Most studies have a limited number of patients and are underpowered. They merely report on short-term results of a heterogeneous intraoperative group using different types of ECC system in aortic valve surgery. The aim of the present study was to determine whether MiECC systems are more beneficial than conventional extracorporeal systems (CECC) with regard to mortality, hospital stay and inflammation and with only haemodilution and blood-air interface as differences. Methods: We retrospectively analysed data regarding mortality, hospital stay and inflammation in patients undergoing isolated aortic valve surgery. Forty patients were divided into two groups based on the type of extracorporeal system used; conventional (n=20) or MiECC (n=20). Results: Perioperative blood product requirements were significantly lower in the MiECC group (MiECC: 0.2±0.5 units vs CECC: 0.9±1.2 units, p=0.004). No differences were seen postoperatively regarding mortality (5% vs 5%, p=0.99), total length of hospital stay (10.6±7.2 days (MiECC) vs 12.1±5.9 days (CECC), p=0.39) or inflammation markers (CRP: MiECC: 7.09±13.62 mg/L vs CECC: 3.4±3.2 mg/L, p=0.89). Conclusion: MiECC provides circulatory support that is equally safe and feasible as conventional extracorporeal circuits. No differences in mortality, hospital stay or inflammation markers were observed.
AMPK Promotes Aberrant PGC1β Expression To Support Human Colon Tumor Cell Survival

ABSTRACT A major goal of cancer research is the identification of tumor-specific vulnerabilities that can be exploited for the development of therapies that are selectively toxic to the tumor. We show here that the transcriptional coactivators peroxisome proliferator-activated receptor gamma coactivator 1β (PGC1β) and estrogen-related receptor α (ERRα) are aberrantly expressed in human colon cell lines and tumors. With kinase suppressor of Ras 1 (KSR1) depletion as a reference standard, we used functional signature ontology (FUSION) analysis to identify the γ1 subunit of AMP-activated protein kinase (AMPK) as an essential contributor to PGC1β expression and colon tumor cell survival. Subsequent analysis revealed that a subunit composition of AMPK (α2β2γ1) is preferred for colorectal cancer cell survival, at least in part, by stabilizing the tumor-specific expression of PGC1β. In contrast, PGC1β and ERRα are not detectable in nontransformed human colon epithelial cells, and depletion of the AMPKγ1 subunit has no effect on their viability. These data indicate that Ras oncogenesis relies on the aberrant activation of a PGC1β-dependent transcriptional pathway via a specific AMPK isoform.
A longitudinal assessment of the persistence of twitter datasets

Social media datasets are not always completely replicable. Having to adhere to requirements of platforms such as Twitter, researchers can only release a list of unique identifiers, which others can then use to recollect the data themselves. This leads to subsets of the data no longer being available, as content can be deleted or user accounts deactivated. To quantify the long‐term impact of this in the replicability of datasets, we perform a longitudinal analysis of the persistence of 30 Twitter datasets, which include more than 147 million tweets. By recollecting Twitter datasets ranging from 0 to 4 years old by using the tweet IDs, we look at four different factors quantifying the extent to which recollected datasets resemble original ones: completeness, representativity, similarity, and changingness. Although the ratio of available tweets keeps decreasing as the dataset gets older, we find that the textual content of the recollected subset is still largely representative of the original dataset. The representativity of the metadata, however, keeps fading over time, both because the dataset shrinks and because certain metadata, such as the users' number of followers, keeps changing. Our study has important implications for researchers sharing and using publicly shared Twitter datasets in their research.
A novel evolutionary pattern of reversed sexual dimorphism in fairy wrens: implications for sexual selection

Reversed sexual dimorphism (females being larger than males) occurs in several bird groups, including hawks and vultures (Accipitridae), falcons (Falconidae), sandpipers and snipe (Scolopacidae), phalaropes (Charadriidae), jacanas (Ja-canidae), skuas (Stercorariidae), boobies (Sulidae), frigate birds (Fregatidae), owls (Strigiformes), cuckoos (Cuculidae), hummingbirds (Trochilidae), manakins (Pipridae), and some ratites (Struthioniformes). In most cases, reversed sexual di-morphism (RSD) is present in many traits, and hence selection has been presumed to act non-independently on several characters (Lande and Arnold, 1983). Hence, RSD has commonly been discussed in terms of differences in body size (Mueller, 1990). In this study, we report a novel pattern of RSD in fairy wrens (Maluridae), which has important evolutionary implications for the ways in which sexual dimorphism can occur and the mechanisms of sexual selection. We examined patterns of morphological sexual dimor-phism, based on published data (Rowley and Russell, 1997; Schodde, 1982) and our own measurements (described later), within a molecular phylogeny for the Maluridae (Christidis and Schodde, 1997). This analysis revealed at least two independent occurrences of RSD in tail length (Figure 1). In one of these cases, the orange-crowned fairy wren Clytomyias in-signis, the reversed dimorphism is associated with a small relative increase in tarsus and wing length in the female, as is commonly observed in species with RSD. However, reversed tail dimorphism in red-backed, white-shouldered and white-winged fairy wrens (M. melanocephalus, M. alboscapulatus, and Malurus leucopterus, respectively) is not associated with an increase in size of other female traits (Table 1). In the first two species, the male is larger in terms of tarsus and wing length, but the female has a significantly longer tail. Two island subspecies of the third species (M. l. leucopterus and M. l. edouardi) show the same pattern, but the mainland subspe-cies (which we have used as the designate species for the phy-logeny) appears monomorphic in terms of tail length (M. l. leuconotus; Table 1). Although tail-length differences have previously been noted for fairy wren species (Schodde, 1982), the classification of RSD has not been formally described or quantitatively studied in any of these species. As far as we are aware, the RSD of a single trait (in an opposite direction to the body size dimorphism) is a novel pattern of evolution of tail elon-gation in birds. In a survey of published incidences of RSD, we could not find a single account that matched the morphological patterns observed in this cluster of three …
Coupled Ocean–Atmosphere Dynamical Processes in the Tropical Indian and Pacific Oceans and the TBO

Abstract The transitions (from relatively strong to relatively weak monsoon) in the tropospheric biennial oscillation (TBO) occur in northern spring for the south Asian or Indian monsoon and northern fall for the Australian monsoon involving coupled land–atmosphere–ocean processes over a large area of the Indo-Pacific region. Transitions from March–May (MAM) to June–September (JJAS) tend to set the system for the next year, with a transition to the opposite sign the following year. Previous analyses of observed data and GCM sensitivity experiments have demonstrated that the TBO (with roughly a 2–3-yr period) encompasses most ENSO years (with their well-known biennial tendency). In addition, there are other years, including many Indian Ocean dipole (or zonal mode) events, that contribute to biennial transitions. Results presented here from observations for composites of TBO evolution confirm earlier results that the Indian and Pacific SST forcings are more dominant in the TBO than circulation and meridiona.
Vestibular Outcome After Cochlear Implantation Is Not Related to Surgical Technique: A Double Blinded, Randomized Clinical Trial of Round Window Approach Versus Cochleostomy

Objective: To establish whether the round window approach (RWA) leads to less vestibular dysfunction and dizziness than the standard cochleostomy approach (SCA) during cochlear implant (CI) surgery, as assessed using the video head impulse test (vHIT). Additionally, objective findings were compared with the subjective dizziness perceived by the patient. Study Design: Double blinded, clinical randomized trial. Setting: University Hospital. Patients: Fifty-two ears from 46 patients were included. Inclusion criterion was a gain value more than 0.50. Intervention: Patients were randomized to the RWA or the SCA. Evaluation with the vHIT was performed before surgery, 1 day after surgery, and 1 month after surgery. Subjective dizziness was measured using a visual analogue scale (VAS) and the dizziness handicap inventory (DHI). Main Outcome Measures: Gain values and the incidence of catch-up saccades. Results: Three out of 23 patients in the SCA group experienced catch-up saccades compared with no patients in the RWA group, indicating the occurrence of objective vestibular dysfunction after CI surgery; the difference was not statistically significant. The VAS increased in both groups the day after surgery. The difference between the groups was not statistically significant. No statistically significant changes in the gain value or the DHI score could were observed between the two groups. Conclusion: No statistically significant difference between the cochleostomy approach and the round window approach using the vHIT and subjective dizziness perceived by the patient was found.
Genome-wide discovery and analysis of single nucleotide polymorphisms and insertions/deletions in Juglans regia L. by high-throughput pyrosequencing.

Walnut (Juglans regia L.) is one of the most widespread economic trees in the world. In this study, genome sequencing of J. regia was performed with Roche 454 GS-FLX sequencer. A total of 541,176 high-quality reads were produced with an average read length of 359 bp. We obtained 31,362 contigs (≥100 bp) after assembling with the Roche Newbler de novo Assembler (Version 2.8); the total length of the assembly was 15.1 Mb. We then mapped all the sequence reads against the J. regia genome assembly. Totally, 49,202 nucleotide variations were detected including 48,165 single nucleotide polymorphisms (SNPs) and 1,037 insertions/deletions (InDels). Among the detected SNPs, the number of transitions (35,480) was much more than that of transversions (12,685), with a ratio of 2.79:1. Within transitions, C/T transitions were slightly more abundant than that of G/A. Among transversions, A/T transversions were much more common than the other three types of transversions. As for the detected InDels, single nucleotide changes accounted for 52.65% of all InDels. Additionally, the InDel numbers were negatively correlated with the InDel lengths.
Co-occurrence of colistin-resistance genes mcr-1 and mcr-3 among multidrug-resistant Escherichia coli isolated from cattle, Spain, September 2015

Colistin resistance genes mcr-3 and mcr-1 have been detected in an Escherichia coli isolate from cattle faeces in a Spanish slaughterhouse in 2015. The sequences of both genes hybridised to same plasmid band of ca 250 kb, although colistin resistance was non-mobilisable. The isolate was producing extended-spectrum beta-lactamases and belonged to serotype O9:H10 and sequence type ST533. Here we report an mcr-3 gene detected in Europe following earlier reports from Asia and the United States.
‘ Poverty , Equity and Growth in Developing and Transition Countries : Statistical Methods and Empirical Analysis

We study the effects of a labor-intensive health care sector within an R&D-driven growth model with overlapping generations. Health care increases longevity and labor participation/productivity. We examine under which conditions expanding health care enhances growth and welfare. Even if the provision of health care diverts labor from productive activities, it may still fuel R&D and economic growth if the additional wealth that comes with expanding longevity translates into a more capital/machineintensive final goods production and, thereby, raises the return to developing new machines. We establish mild conditions under which an expansion of health care beyond the growth-maximizing level is Pareto-improving. JEL classification: I15, I18, O11, O41, O43
Development and Validation of Ovarian Symptom Index-18 and Neurotoxicity-4 for Korean Patients with Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

Purpose The purpose of this study was to develop Korean versions of the National Comprehensive Cancer Network/Functional Assessment of Cancer Therapy (NCCN-FACT) Ovarian Symptom Index-18 (NFOSI-18) and FACT/Gynecologic Oncology Group (FACT-GOG) Neurotoxicity 4-item (NTX-4), evaluating their reliability and reproducibility. Materials and Methods In converting NFOSI-18 and NTX-4, the following steps were performed: forward translation, backward translation, expert review, pretest of preliminary format, and finalization of Korean versions (K-NFOSI-18 and K-NTX-4). Patients were enrolled from six institutions where each had completed chemotherapy for ovarian, tubal, or peritoneal cancer at least 1 month earlier. In addition to demographics obtained by questionnaire, all subjects were assessed via K-NFOSI-18, K-NTX-4, and a Korean version of the EuroQoL-5 Dimension. Internal structural validity and reliability were evaluated using item internal consistency, item discriminant validity, and Cronbach's α. To evaluate test-retest reliability, K-NFOSI-18 and K-NTX-4 were readministered after 7-21 days, and intraclass correlation coefficients (ICCs) were calculated. Results Of the 250 women enrolled during the 3-month recruitment period, 13 withdrew or did not respond, leaving 237 (94.8%) for the analyses. Mean patient age was 54.3±10.8 years. Re-testing was performed in 190 patients (80.2%). The total K-NFOSI-18 and K-NTX-4 scores were 49 (range, 20 to 72) and 9 (range, 0 to 16), respectively, with high reliability (Cronbach's α=0.84 and 0.89, respectively) and reproducibility (ICC=0.77 and 0.84, respectively) achieved in retesting. Conclusion Both NFOSI-18 and NTX-4 were successfully developed in Korean with minimal modification. Each Korean version showed high internal consistency and reproducibility.
An Ontology Systems Approach on Human Brain Expression and Metaproteomics

Research in the last decade has shown growing evidence of the gut microbiota influence on brain physiology. While many mechanisms of this influence have been proposed in animal models, most studies in humans are the result of a pathology–dysbiosis association and very few have related the presence of certain taxa with brain substructures or molecular pathways. In this paper, we associated the functional ontologies in the differential expression of brain substructures from the Allen Brain Atlas database, with those of the metaproteome from the Human Microbiome Project. Our results showed several coherent clustered ontologies where many taxa could influence brain expression and physiology. A detailed analysis of psychobiotics showed specific slim ontologies functionally associated with substructures in the basal ganglia and cerebellar cortex. Some of the most relevant slim ontology groups are related to Ion transport, Membrane potential, Synapse, DNA and RNA metabolism, and Antigen processing, while the most relevant neuropathology found was Parkinson disease. In some of these cases, new hypothetical gut microbiota-brain interaction pathways are proposed.
The importance of multiple assessments of object knowledge in semantic dementia: The case of the familiar objects task

Semantic dementia (SD) is characterized by a dramatic loss of conceptual knowledge about the meaning of words and the identity of objects. Previous research has suggested that SD patients' knowledge is differentially influenced by the disease and may decline at different degrees depending on a patient's everyday familiarity with certain items. However, no study has examined (a) semantic knowledge deterioration and (b) the potential significance of autobiographical experience for the maintenance of object concepts in the same cohort of SD patients by using comprehensive assessments of different aspects of object knowledge across an experience-based, distributed semantic memory network. Here, we tested four SD patients and three Alzheimer's disease (AD) control patients using a range of tasks – including naming, gesture generation, and autobiographical knowledge – with personally familiar objects or perceptually similar or different object analogs. Our results showed dissociations between performance on naming relative to other assessments of object knowledge between SD and AD patients, though we did not observe a reliable familiar objects advantage. We discuss different factors that may account for these findings, as well as their implications for research on SD.