Miracle-dz/UniFAR-FTUs huggingface dataset:
Fast checkpoint recovery algorithms for frequently consistent applications

Advances in hardware have enabled many long-running applications to execute entirely in main memory. As a result, these applications have increasingly turned to database techniques to ensure durability in the event of a crash. However, many of these applications, such as massively multiplayer online games and main-memory OLTP systems, must sustain extremely high update rates - often hundreds of thousands of updates per second. Providing durability for these applications without introducing excessive overhead or latency spikes remains a challenge for application developers. In this paper, we take advantage of frequent points of consistency in many of these applications to develop novel checkpoint recovery algorithms that trade additional space in main memory for significantly lower overhead and latency. Compared to previous work, our new algorithms do not require any locking or bulk copies of the application state. Our experimental evaluation shows that one of our new algorithms attains nearly constant latency and reduces overhead by more than an order of magnitude for low to medium update rates. Additionally, in a heavily loaded main-memory transaction processing system, it still reduces overhead by more than a factor of two.
Distal bowel selectivity in the chemoprevention of experimental colon carcinogenesis by the non‐steroidal anti‐inflammatory drug nabumetone

Use of non‐steroidal anti‐inflammatory drugs (NSAIDs) for chemoprevention of colon cancer has been hindered by their potential gastro‐intestinal toxicity. Nabumetone, which is approximately 10 to 36 times safer than conventional NSAIDs, was evaluated in 2 models of experimental colon carcinogenesis. In azoxymethane (AOM)‐treated Fisher 344 rats, nabumetone caused dose‐dependent inhibition of aberrant crypt foci (ACF), with 750 and 1,500 ppm resulting in 15% and 37% reductions, respectively (p < 0.05). Moreover, complex ACF were reduced by 48% in the latter group. MIN mice studies confirmed the chemopreventive efficacy of nabumetone, with 900 ppm suppressing approximately half of the intestinal tumors. Interestingly, inhibition of intermediate biomarkers in both models was markedly greater in the distal than the proximal bowel. To mechanistically evaluate this regional selectivity, we assessed cyclo‐oxygenase‐2 (COX‐2) expression in the uninvolved mucosa and demonstrated a 3‐ to 4‐fold excess in the distal relative to the proximal bowel in both MIN mice and AOM‐treated rats. We then investigated another putative NSAID target, peroxisome proliferator–activated receptor‐δ (PPAR‐δ) and demonstrated up‐regulation during AOM‐induced colonic tumorigenesis. Furthermore, in pre‐neoplastic mucosa, there was a 3‐fold excess of PPAR‐δ in the distal colon. We demonstrate that nabumetone is an effective protective agent in both experimental models of colon carcinogenesis. The striking distal predilection of nabumetone may be, at least partially, explained by distal bowel over‐expression of COX‐2 and PPAR‐δ. © 2001 Wiley‐Liss, Inc.
Energy metabolism during activity-promoting video games practice in subjects with spinal cord injury: evidences for health promotion.

BACKGROUND Activity promoting video game (APVG) practice significantly affects energy metabolism through energy expenditure (EE) increase and has been recently included in strategies for health promotion. It is not known if the APVG practice provides similar outcomes in subjects with spinal cord injury (SCI). AIM Aim of the study was to evaluate cardio-pulmonary and metabolic adaptations during APVG practice and to find whether EE increase above resting condition could suggest the inclusion of this exercise in a more general strategy for health promotion and body weight control in subjects with SCI. DESIGN Repeated measures study. SETTING Rehabilitation Institute. POPULATION Ten male subjects with SCI (lesion levels from C7 to L1) age 26 to 55 years. METHODS We recorded pulmonary ventilation (VE), oxygen consumption (VO2) for EE esteem and heart rate (HR) at rest and while playing virtual bowling, tennis and boxing games using a portable metabolimeter equipped with ECG electrodes. The standard metabolic equivalent of task (METs) was calculated offline. The metabolic and functional parameters were referred to the 10th minute of each activity. RESULTS Metabolic and functional parameters increased significantly from rest to bowling, tennis and boxing. METs exceeded in average 3 during boxing. One hour of APVG can increase daily EE by about 6% (bowling), 10% (tennis) and 15% (boxing). CONCLUSION These considerable results suggest that physical exertion during APVG practice in subjects with SCI could contribute to health promotion as well as caloric balance control, especially when boxing is considered. This can be safely achieved at home with regular activity. CLINICAL REHABILITATION IMPACT These findings substantiate the potential for novel exercise modalities to counteract deconditioning due to inactivity in subjects with SCI by promoting physical activity through implementation of APVG exercise programs.
Astrocytes spatially restrict VEGF signaling by polarized secretion and incorporation of VEGF into the actively assembling extracellular matrix

The spatial organization of vascular endothelial growth factor (VEGF) signaling is a key determinant of vascular patterning during development and tissue repair. How VEGF signaling becomes spatially restricted and the role of VEGF secreting astrocytes in this process remains poorly understood. Using a VEGF‐GFP fusion protein and confocal time‐lapse microscopy, we observed the intracellular routing, secretion and immobilization of VEGF in scratch‐activated living astrocytes. We found VEGF to be directly transported to cell‐extracellular matrix attachments where it is incorporated into fibronectin fibrils. VEGF accumulated at β1 integrin containing fibrillar adhesions and was translocated along the cell surface prior to internalization and degradation. We also found that only the astrocyte‐derived, matrix‐bound, and not soluble VEGF decreases β1 integrin turnover in fibrillar adhesions. We suggest that polarized VEGF release and ECM remodeling by VEGF secreting cells is key to control the local concentration and signaling of VEGF. Our findings highlight the importance of astrocytes in directing VEGF functions and identify these mechanisms as promising target for angiogenic approaches. GLIA 2016;64:440–456
Administration Time–Dependent Influence of Aspirin on Blood Pressure in Pregnant Women

Abstract—This study prospectively investigates the potential influence of low-dose aspirin on blood pressure in pregnant women who were at a higher risk of developing preeclampsia than that of the general obstetric population and who received aspirin at different times of the day according to their rest-activity cycle. A double-blind, randomized, controlled trial was conducted in 341 pregnant women (181 primipara) randomly assigned to 1 of 6 possible groups according to treatment (either placebo or aspirin, 100 mg/day, starting at 12 to 16 weeks of gestation) and the time of treatment: on awakening (time 1), 8 hours after awakening (time 2), or before bedtime (time 3). Blood pressure was automatically monitored for 48 consecutive hours every 4 weeks from the day of recruitment until delivery, as well as at puerperium. There was no effect of aspirin on blood pressure at time 1 (compared with placebo). A blood pressure reduction was highly statistically significant when aspirin was given at time 2 and, to a greater extent, at time 3 (mean reductions of 9.7/6.5 mm Hg in 24-hour mean for systolic/diastolic blood pressure at the time of delivery as compared with placebo given at bedtime). Differences in blood pressure among women receiving aspirin at different circadian times disappeared at puerperium (P >0.096). Results indicate a highly significant effect of aspirin on blood pressure that is markedly dependent on the time of aspirin administration with respect to the rest-activity cycle. Timed use of aspirin at low dose effectively contributes to blood pressure control in women at high risk for preeclampsia.
Novel contributions on luminescent apatite-based colloids intended for medical imaging

The setup of colloidal hybrid nanosystems based on biomimetic calcium phosphate apatites doped with europium ions has recently raised great interest in the pharmacological community, especially due to their bio-inspired character. This is especially relevant in relation with medical imaging for cancer diagnosis. Questions however remain in relation to a number of applicability aspects, some of which have been examined in this contribution. In a first part of this work, we explored further the luminescence properties of such colloidal nanoparticles. We pointed out, upon excitation of europium, the existence of some non-radiative de-excitation via the vibration of O-H oscillators located at the vicinity of the Eu3+ luminescent centers. The replacement of Eu3+ by Tb3+ ions, less prone to non-radiative de-excitation, was then tested in a preliminary way and can be seen as a promising alternative. In a second part of this work, we inspected the possibility to store these colloids in a dry state while retaining a re-suspension ability preserving the nanometer size of the initial nanoparticles, and we propose a functional protocol involving the addition of glucose prior to freeze-drying. We finally showed for the first time, based on titrations of intracellular Ca2+ and Eu3+ ions, that folic acid-functionalized biomimetic apatite nanoparticles were able to target cancer cells that overexpress folate receptors on their membrane, which we point out here in the case of T-47-D breast carcinoma cells, as opposed to ZR-75-1 cells that do not express folate receptors. This contribution thus opens new exciting perspectives in the field of targeted cancer diagnosis, thus confirming the promise of biomimetic apatites-based colloidal formulations.
Pruning of memories by context-based prediction error

Significance Forgetting is often considered to be bad, but selective forgetting of unreliable information can have the positive side effect of reducing mental clutter, thereby making it easier to access our most important memories. Prior studies of forgetting have focused on passive mechanisms (decay, interference) or on effortful inhibition by cognitive control. Here we report the discovery of an active mechanism for forgetting that weakens memories selectively and without burdening the conscious mind. Specifically, we show that the brain automatically generates predictions about which items should appear in familiar contexts; if these items fail to appear, their memories are weakened. This process is adaptive, because such memories may have been encoded incorrectly or may represent unstable aspects of the world. The capacity of long-term memory is thought to be virtually unlimited. However, our memory bank may need to be pruned regularly to ensure that the information most important for behavior can be stored and accessed efficiently. Using functional magnetic resonance imaging of the human brain, we report the discovery of a context-based mechanism for determining which memories to prune. Specifically, when a previously experienced context is reencountered, the brain automatically generates predictions about which items should appear in that context. If an item fails to appear when strongly expected, its representation in memory is weakened, and it is more likely to be forgotten. We find robust support for this mechanism using multivariate pattern classification and pattern similarity analyses. The results are explained by a model in which context-based predictions activate item representations just enough for them to be weakened during a misprediction. These findings reveal an ongoing and adaptive process for pruning unreliable memories.
Model adaptation with least-squares SVM for adaptive hand prosthetics

The state-of-the-art in control of hand prosthetics is far from optimal. The main control interface is represented by surface electromyography (EMG): the activation potentials of the remnants of large muscles of the stump are used in a non-natural way to control one or, at best, two degrees-of-freedom. This has two drawbacks: first, the dexterity of the prosthesis is limited, leading to poor interaction with the environment; second, the patient undergoes a long training time. As more dexterous hand prostheses are put on the market, the need for a finer and more natural control arises. Machine learning can be employed to this end. A desired feature is that of providing a pre-trained model to the patient, so that a quicker and better interaction can be obtained. To this end we propose model adaptation with least-squares SVMs, a technique that allows the automatic tuning of the degree of adaptation. We test the effectiveness of the approach on a database of EMG signals gathered from human subjects. We show that, when pre-trained models are used, the number of training samples needed to reach a certain performance is reduced, and the overall performance is increased, compared to what would be achieved by starting from scratch.
Preventive Effect of Shorea Robusta Bark Extract against Diethylnitrosamine -Induced Hepatocellular Carcinoma in Rats

Antioxidants are one of the key players in tumorigenesis, several natural and synthetic antioxidants were shown to have anticancer effects. The aim of the present study is to divulge the preventive nature of Shorea robusta bark extract (SRBE) during diethylnitrosamine (DEN)-induced liver cancer in male Wistar albino rats. Administration of DEN to rats resulted in increased serum marker enzymes aspartate transaminase (AST), alanine transaminase (ALT), lactate dehydrogenase (LDH), and gamma glutamyl transpeptidase (GGT). The levels of lipid peroxides elevated with subsequent decrease in the tissue antioxidants like superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH), glutathione peroxidase (GPx), and glutathione reductase (GR). SRBE supplementation (500mg/kg body weight) significantly attenuated these alterations, thereby showing potent anticancer effect in liver cancer. These findings suggest that SRBE prevents lipid peroxidation, hepatic cell damage, and protects the antioxidant system in DEN-induced hepatocellular carcinogenesis.
Enhancing diagnosis resolution for delay defects based upon statistical timing and statistical fault models

In this paper, we propose a new methodology for diagnosis of delay defects in the deep submicron domain. The key difference between our diagnosis framework and other traditional diagnosis methods lies in our assumptions of the statistical circuit timing and the statistical delay defect size. Due to the statistical nature of the problem, achieving 100% diagnosis resolution cannot be guaranteed. To enhance diagnosis resolution, we propose a 3-phase diagnosis methodology. In the first phase, our goal is to quickly identify a set of candidate suspect faults that are most likely to cause the failing behavior based on logic constraints. In the second phase, we obtain a much smaller suspect fault set by applying a novel diagnosis algorithm that can effectively utilize the statistical timing information based upon a single defect assumption. In the third phase, our goal is to apply additional fine-tuned patterns to successfully narrow down to more exact suspect defect locations. Using a statistical timing analysis framework, we demonstrate the effectiveness of the proposed methodology for delay defect diagnosis, and discuss experimental results based on benchmark circuits.
International Studies Program

This paper reviews the current knowledge on an issue of increasing policy interest: what impact fiscal decentralization has on economic growth. Fiscal decentralization may indeed have a direct impact on economic growth but the theoretical underpinnings for this relationship remain largely undeveloped. The absence of an adequate theoretical framework has undermined the validity of the empirical work on this subject. A fair summary of the empirical search for a direct relationship between fiscal decentralization and economic growth is that it remains an open question. Much less attention has been devoted in the literature to the indirect channels through which fiscal decentralization may affect economic growth, through the impact of fiscal decentralization on economic efficiency, the regional distribution of resources, and macroeconomic stability. This paper explorers the nature of these links and concludes with some thoughts and policy advice. JEL Classification Numbers: E62, H77
Testosterone therapy can enhance erectile function response to sildenafil in patients with PADAM: a pilot study.

INTRODUCTION Recent studies suggest a direct relationship between free testosterone and cavernous vasodilatation. Some men with erectile dysfunction (ED) associated with PADAM (partial androgen deficiency in aging men) might possibly benefit from testosterone undecanoate therapy (TRT). OBJECTIVES To determine the efficacy of testosterone undecanoate in facilitating the erectile response and patient satisfaction with sildenafil in men 40-70 years old with PADAM symptoms. DESIGN AND METHODS Prospective study including 40 patients recruited after a sildenafil therapeutic trial. Total testosterone and sex hormone binding globulin (SHBG) were measured to calculate the free androgen index. Prostate specific antigen (PSA) was measured and repeated 2 months after treatment. A rating score was used for PADAM symptoms, and the 5-point abbreviated version of the International Index of Erectile Function (IIEF-5) to assess erectile function. Men failing to respond to sildenafil were randomized into two groups receiving sildenafil plus continuous TRT (group 1ST), and TRT (group 1T) alone. Men partially responding to sildenafil were randomized into two groups receiving sildenafil plus continuous TRT for 2 months (group 2ST), or sildenafil alone (group 2S). Treatment efficacy was assessed by analysis of between-group differences. RESULTS Groups 1T, 2S, and 2ST showed significant improvement in PADAM scores (P<0.05, Wilcoxon matched pairs test). Patients receiving both sildenafil plus continuous TRT (groups 1ST and 2ST) showed significant improvement in IIEF-5 scores (P<0.5, paired t-test). No significant changes in serum levels of PSA were detected (paired t-test). CONCLUSIONS We conclude that TRT appears to be beneficial and safe in facilitating the erectile response and patient satisfaction with sildenafil in men with PADAM symptoms. Androgen supplementation should be carried out cautiously with careful monitoring to avoid possible adverse effects.
Measuring the Photopic Negative Response: Viability of Skin Electrodes and Variability Across Disease Severities in Glaucoma

Purpose The purpose of this study was to determine the feasibility of measuring the photopic negative response (PhNR) of the full-field electroretinogram (ERG) using skin electrodes compared to conjunctival electrodes and its test–retest variability over a range of disease severities in open-angle glaucoma. Methods Recordings were performed twice (100 sweeps each) within the same session in 43 eyes of 23 participants with glaucoma to determine its intrinsic variability. The ratio between the PhNR and B-wave amplitude (PhNR/B ratio) was determined for each trace and computed across 5 to 100 sweeps of each recording. Spectral-domain optical coherence tomography was used to measure the average peripapillary retinal nerve fiber layer (RNFL) thickness. Results The PhNR/B ratio and its magnitude of variability were not significantly different between skin and conjunctival electrodes (P ≤ 0.197), and the degree of variability decreased substantially with increasing number of sweeps. For skin electrodes, the intraclass correlation coefficient was 0.89 and 0.91 for right and left eyes, respectively. The variability of the PhNR/B ratio decreased with lower RNFL thickness values and larger B-wave amplitudes (P ≤ 0.002). Conclusions Skin electrodes are a viable alternative to conjunctival electrodes when measuring the PhNR in open angle glaucoma, and increasing the number of sweeps substantially reduced its intrinsic variability; the extent of variability was also lower with worsening disease severity. Translational Relevance The feasibility of performing ERG recordings widely across a range of disease severities in glaucoma can be achieved through using skin electrodes and increasing the number of sweeps performed to improve measurement repeatability.
Cancer Incidence and Mortality in Patients with Type 2 Diabetes Treated with Human Insulin: A Cohort Study in Shanghai

Aim The aim was to investigate the association between human insulin and cancer incidence and mortality in Chinese patients with type 2 diabetes. Methods We recruited 8,774 insulin-naïve diabetes patients from the Shanghai Diabetes Registry (SDR). The follow-up rate was 85.4%. All subjects were divided into the insulin use cohort (n = 3,639) and the non-insulin use cohort (n = 5,135). The primary outcome was the first diagnosis of any cancer. The secondary outcome was all-cause mortality. Cox proportional hazards model was used to estimate the relative risk (RR) of cancer and mortality. Results We observed 98 cancer events in the insulin use cohort and 170 in the non-insulin use cohort. Cancer incidence rates were 78.6 and 74.3 per 10,000 patients per year in the insulin users and the non-insulin users, respectively. No significant difference in cancer risk was observed between the two cohorts (adjusted RR = 1.20, 95% CI 0.89–1.62, P = 0.228). Regarding site-specific cancers, only the risk of liver cancer was significantly higher in the insulin users compared to that in the non-insulin users (adjusted RR = 2.84, 95% CI 1.12–7.17, P = 0.028). The risks of overall mortality (adjusted RR = 1.89, 95% CI 1.47–2.43, P<0.0001) and death from cancer (adjusted RR = 2.16, 95% CI 1.39–3.35, P = 0.001) were all significantly higher in the insulin users than in the non-insulin users. Conclusion There was no excess risk of overall cancer in patients with type 2 diabetes who were treated with human insulin. However, a significantly higher risk of liver cancer was found in these patients. Moreover, insulin users showed higher risks of overall and cancer mortality. Considering that individuals treated with insulin were more likely to be advanced diabetic patients, caution should be used in interpreting these results.
Association of Transforming Growth Factor Alpha Polymorphisms with Nonsyndromic Cleft Lip and Palate in Iranian Population

Background: Cleft lip with or without cleft palate (CL/P) is one of the most common congenital anomalies and the etiology of orofacial clefts is multifactorial. Transforming growth factor alpha (TGFA) is expressed at the medial edge epithelium of fusing palatal shelves during craniofacial development. In this study, the association of two important TGFA gene polymorphisms, BamHI (rs11466297) and RsaI (rs3732248), with CL/P was evaluated in an Iranian population. Methods: The frequencies of BamHI and RsaI variations were determined in 105 unrelated Iranian subjects with nonsyndromic CL/P and 218 control subjects using PCR and RFLP methods, and the results were compared with healthy controls. A p-value of <0.05 was considered statistically significant. Results: The BamHI AC genotype was significantly higher (p=0.016) in the patients (12.4%) than the control group (5.0%). The BamHI C allele was significantly higher (p=0.001; OR=3.4, 95% CI: 1.6–7.4) in the cases (8.0%) compared with the control group (2.5%). Conclusion: Our study showed that there was an association between the TGFA BamHI variation and nonsyndromic CL/P in Iranian population.