Miracle-dz/UniFAR-FTUs huggingface dataset:
Use of Traditional Weather/Climate Knowledge by Farmers in the South-Western Free State of South Africa: Agrometeorological Learning by Scientists

The variety of natural indicators, associated with weather forecasting and climate prediction, as used by farmers in the South-Western Free State province of South Africa, is described. Most farmers in this area were not familiar with the application of weather forecasts/climate predictions for agricultural production, or with other science-based agrometeorological products. They relied almost fully on their experience and traditional knowledge for farming decision making. The indicators for traditional knowledge are demonstrated here in broad terms, relying on the stories and indications from observations and years of experience of their use by the farmers. These means of engagement with the natural environment, are skills not well understood by most scientists, but useful to the farmers. They range from the constellation of stars, animal behavior, cloud cover and type, blossoming of certain indigenous trees, appearance and disappearance of reptiles, to migration of bird species and many others. It is suggested that some short-term traditional forecasts/predictions may be successfully merged with science-based climate predictions. The traditional knowledge and its use, reported on in this paper, is what scientists learned from farmers. Berkes was right that scholars have wasted too much time and effort on a science versus traditional knowledge debate; we should reframe it instead as a science and traditional knowledge dialogue and partnership. The complications of a changing climate make this even more necessary.
Face recognition in 4- to 7-year-olds: processing of configural, featural, and paraphernalia information.

We tested 4- to 7-year-old children's face recognition by manipulating the faces' configural and featural information and the presence of superfluous paraphernalia. Results indicated that even with only a single 5-s exposure to the target face, most children could use configural and feature cues to make identity judgments. Repeated exposure and experimenter feedback enabled other children to do so as well. Even after attaining proficiency at identifying the target face, however, children's recognition was impaired when a superfluous hat was added to the face. Thus, although young children can process featural and configural face information, their memories are highly susceptible to disruption from superfluous paraphernalia.
Automating and informating: roles to examine technology’s impact on performance

ABSTRACT Previous studies on the impact of technology on performance (usefulness) have looked at the Information System (IS) in its role as supplier of information (informating role) and thus they have studied the influence of information quality and system quality on usefulness. However, an IS also has a role in the automation of tasks (automating role), which these studies do not take into account. Accordingly, this paper proposes a factor model that (1) includes explicitly both roles; (2) considers that informating and automating roles mediate the relation between these technological factors (information quality and system quality) and usefulness and (3) includes a system’s level of intervention (i.e. the degree to which technology participates in carrying out the tasks) as an additional factor that determines usefulness. Using a questionnaire, data were gathered on 229 Enterprise Resource Planning system users from different organisations and functional areas and structural equations model was used for analysis. Results show that information quality explains usefulness through both roles. System’s level of intervention explains usefulness through the automating role and system quality explains usefulness through the informating role. The factors’ differentiated effects through each role may help managers to establish more effective criteria and priorities in the various stages of an IS’s life cycle.
Interactions of Calcium with Sodium and Potassium in Membrane Potentials of the Lobster Giant Axon

Experiments were performed on the lobster giant axon to determine the relation between intracellular spike amplitude and external calcium ion concentration. Action potential decline in low external calcium is greatly accelerated by simultaneous removal of external sodium ion. Correlation of the time course of spike decline in low calcium-low sodium solution with the time courses of spike decline in low calcium alone and in low sodium alone indicates that the effect of simultaneous removal of both ions is significantly greater than the sum of the individual effects. For a given time of treatment, spike amplitude was a function of external calcium concentration. While spike height is proportional to the log of the external calcium concentration over the range 2.5 to 50 millimolar, the proportionality constant is dependent upon the sodium concentration. Under the conditions of low external sodium (50 per cent reduction) the slope of the linear relationship between the spike height and the log of the external calcium concentration is about 5 times greater than in normal external sodium. Decreasing external calcium concentration and simultaneously increasing external potassium concentration produce a greater spike reduction than the arithmetic sum of spike reductions in low calcium alone and in high potassium alone. It is suggested that calcium interacts strongly with sodium and potassium in the spike-generating mechanism. A theoretical basis for these results is discussed.
FcεRI stimulation promotes the differentiation of histamine receptor 1‐expressing inflammatory macrophages

Monocyte differentiation into dendritic cells or macrophages and recruitment to peripheral organs in chronic inflammatory diseases are directed by allergen challenge via FcεRI as well as the nature of soluble factors in the microenvironment. High‐affinity receptor for IgE stimulation of effector cells results in the release of histamine, which acts on various histamine receptors (HR) 1‐4, expressed by immune cells.
Uncertainty relations for a non-canonical phase-space noncommutative algebra

We consider a non-canonical phase-space deformation of the Heisenberg–Weyl algebra that was recently introduced in the context of quantum cosmology. We prove the existence of minimal uncertainties for all pairs of non-commuting variables. We also show that the states which minimize each uncertainty inequality are ground states of certain positive operators. The algebra is shown to be stable and to violate the usual Heisenberg–Pauli–Weyl inequality for position and momentum. The techniques used are potentially interesting in the context of time-frequency analysis.
EGLN2 and RNF150 genetic variants are associated with chronic obstructive pulmonary disease risk in the Chinese population

Purpose Chronic obstructive pulmonary disease (COPD) is a major and an increasingly prevalent health problem worldwide. It has been reported that genetic variation may play a role in the development and severity of COPD. The purpose of this study was to investigate whether single nucleotide polymorphisms in multiple genetic variants were associated with COPD in a Chinese population from Hainan province. Methods In this case-control study, including 200 COPD patients and 401 controls, we genotyped 14 tag single nucleotide polymorphisms and evaluated their association with COPD using the χ2 test and genetic model analysis. Results The polymorphism, rs10007052, in the RNF150 gene was significantly associated with COPD risk at a 5% level (odds ratio =1.43, 95% confidence interval, 1.06–1.95, P=0.020). In the log-additive model, the minor allele (C) of rs10007052 in the RNF150 gene (P=0.026) and the minor allele (C) of rs3733829 in the EGLN2 gene (P=0.037) were associated with COPD risk after adjustment for age, sex, and smoking status. Further haplotype analysis revealed that the “CT” haplotype composed of the mutant allele (C) of rs7937, rs3733829 in the EGLN2 gene, was associated with increased COPD risk (odds ratio =1.55; 95% confidence interval, 1.05–2.31; P=0.029). Conclusion Our findings indicated that rs10007052 in the RNF150 and rs3733829 in the EGLN2 gene were significantly associated with the risk of COPD in Chinese populations of Hainan province. These data may provide novel insights into the pathogenesis of COPD, although further studies with larger numbers of participants worldwide are needed for validation of our conclusions.
Evaluation of Diversification Techniques for Legal Information Retrieval

“Public legal information from all countries and international institutions is part of the common heritage of humanity. Maximizing access to this information promotes justice and the rule of law”. In accordance with the aforementioned declaration on free access to law by legal information institutes of the world, a plethora of legal information is available through the Internet, while the provision of legal information has never before been easier. Given that law is accessed by a much wider group of people, the majority of whom are not legally trained or qualified, diversification techniques should be employed in the context of legal information retrieval, as to increase user satisfaction. We address the diversification of results in legal search by adopting several state of the art methods from the web search, network analysis and text summarization domains. We provide an exhaustive evaluation of the methods, using a standard dataset from the common law domain that we objectively annotated with relevance judgments for this purpose. Our results: (i) reveal that users receive broader insights across the results they get from a legal information retrieval system; (ii) demonstrate that web search diversification techniques outperform other approaches (e.g., summarization-based, graph-based methods) in the context of legal diversification; and (iii) offer balance boundaries between reinforcing relevant documents or sampling the information space around the legal query.
Safety Performance Functions for Low-Volume Rural Stop-Controlled Intersections

This study involved the development of safety performance functions for rural, low-volume, minor road stop-controlled intersections in Michigan. Facility types included three-leg stop-controlled (3ST) and four-leg stop-controlled (4ST) intersections under state or county jurisdiction and were sampled from each of Michigan’s 83 counties. To isolate lower-volume rural intersections, major roadway traffic volumes were limited to the range of 400–2,000 vehicles per day (vpd). Data were compiled from several sources for 2,023 intersections statewide. These data included traffic crashes, volumes, roadway classification, geometry, cross-sectional features, and other site characteristics covering the period of 2011–2015. Random effects negative binomial regression models were specified for each stop-controlled intersection type considering factors such as driveway density, lighting presence, turn lane presence, and intersection skew, in addition to volume. To account for the unobserved heterogeneity between counties, mixed effects negative binomial models with a county-specific random effect were utilized. Furthermore, unobserved temporal effects were controlled through the use of a year-specific random effect. Separate models were developed for fatal/injury crashes, property damage crashes, and select target crash types. The analysis found that skew angles of greater than five degrees led to significantly greater crash occurrence for both 3ST and 4ST intersections, while greater than two driveways near the intersection led to significantly greater angle crashes at 4ST intersections. Other factors were found to have little impact on crash occurrence. Comparison with the Highway Safety Manual (HSM) base models showed that the HSM models over-predict crashes on 4ST intersections and 3ST intersections with volumes between 1,200 and 2,000 vpd.
Low MUC4 expression is associated with survival benefit in patients with resectable pancreatic cancer receiving adjuvant gemcitabine

Abstract Background: Previous in vitro studies have shown that mucin 4 (MUC4) confers resistance toward gemcitabine in pancreatic cancer cells. To date, there are few clinical studies corroborating these findings. The aim of this study was to evaluate the predictive impact of MUC4 expression on survival in patients with resectable pancreatic cancer receiving adjuvant gemcitabine. Materials and methods: MUC4 expression was investigated by immunohistochemistry in 78 tissue sections from patients with pancreatic ductal adenocarcinoma undergoing Whipple resection. The H-score was used to evaluate MUC4 expression. The Kaplan–Meier method and Cox proportional hazards regression analysis were used to assess the predictive role of MUC4 expression. Results: The MUC4 protein was expressed in 93.6% (73/78) of pancreatic cancer tissue specimens. None of the normal control pancreatic tissues had any MUC4 expression. Low MUC4 expression (H-score ≤100) was detectable in 42 (53.8%) of tumors and high MUC4 expression (H-score >100) was detectable in 36 (46.2%) of tumors. Low expression of MUC4 was associated with favorable survival (p = .027), whereas high MUC4 expression did not correlate with survival (p = .87) in patients receiving adjuvant gemcitabine treatment. Conclusions: This is the first study indicating a predictive role of MUC4 expression for gemcitabine treatment in the clinical setting.
Peadiatric Tuberculosis: Is the World Doing Enough?

Until recently, tuberculosis (TB) had become a neglected disease, particularly in children. It was after the emergence of multi drug resistant TB, and the complications brought about by the HIV/AIDS coinfection, that TB took centre stage again. The common perception has been that children rarely develop severe forms of TB and that they do not contribute much to the spread of the epidemic. Although this could be the case in non-endemic areas, where diligent contact tracing is enforced, in children from endemic areas it is a different story as revealed by an autopsy study conducted in Zambia which demonstrated that tuberculosis was a major cause of death from respiratory disease (Chintu et al., 2002).
The Troposphere-to-Stratosphere Transition in Kinetic Energy Spectra and Nonlinear Spectral Fluxes as Seen in ECMWF Analyses

AbstractGlobal horizontal wavenumber kinetic energy spectra and spectral fluxes of rotational kinetic energy and enstrophy are computed for a range of vertical levels using a T799 ECMWF operational analysis. Above 250 hPa, the kinetic energy spectra exhibit a distinct break between steep and shallow spectral ranges, reminiscent of dual power-law spectra seen in aircraft data and high-resolution general circulation models. The break separates a large-scale “balanced” regime in which rotational flow strongly dominates divergent flow and a mesoscale “unbalanced” regime where divergent energy is comparable to or larger than rotational energy. Between 230 and 100 hPa, the spectral break shifts to larger scales (from n = 60 to n = 20, where n is spherical harmonic index) as the balanced component of the flow preferentially decays. The location of the break remains fairly stable throughout the stratosphere. The spectral break in the analysis occurs at somewhat larger scales than the break seen in aircraft data.
Tests of 'fanning out' of indifference curves: Results from animal and human experiments

In an earlier paper (Raymond C. Battalio, John H. Kagel, and Don N. Mac Donald, 1985), we reported Allais-type violations of the independence axiom of expected utility theory with rats choosing over positively valued payoffs (food rewards). This note extends this research, examining animals' choices over losses, testing for (1) standard Allais-type common ratio effect violations of expected utility theory and (2) fanning out of indifference curves for random prospects, tests of Mark J. Machina's (1982, 1987) hypothesis II (hereafter H2), over previously unexplored areas of the unit probability triangle. Results from a parallel series of experiments using human subjects choosing over real losses are also reported. For both rats and people, we find standard Allais-type violations of expected utility theory and a systematic failure of the fanning out hypothesis in the southeast corner of the unit probability triangle, in the case of losses. Thus, the fanning out hypothesis (Machina 1982, 1987) cannot provide a satisfactory explanation for behavioral deviations from expected utility theory.
Driving magma to the surface: The 2011–2012 El Hierro Volcanic Eruption

We reanalyzed the seismic and deformation data corresponding to the preeruptive unrest on El Hierro (Canary Islands) in 2011. We considered new information about the internal structure of the island. We updated the seismic catalog to estimate the full evolution of the released seismic energy and demonstrate the importance of nonlocated earthquakes. Using seismic data and GPS displacements, we characterized the shear‐tensile type of the predominant fracturing and modeled the strain and stress fields for different time periods. This enabled us to identify a prolonged first phase characterized by hydraulic tensile fracturing, which we interpret as being related to the emplacement of new magma below the volcanic edifice on El Hierro. This was followed by postinjection unidirectional migration, probably controlled by the stress field and the distribution of the structural discontinuities. We identified the effects of energetic magmatic pulses occurring a few days before the eruption that induced shear seismicity on preexisting faults within the volcano and raised the Coulomb stress over the whole crust. We suggest that these magmatic pulses reflect the crossing of the Moho discontinuity, as well as changes in the path geometry of the dyke migration toward the surface. The final phase involved magma ascent through a prefractured crust.
Comparison of Polyethylene Glycol versus Lactulose Oral Solution for Bowel Preparation prior to Colonoscopy

Objective This study was conducted to compare a lactulose oral solution with a polyethylene glycol (PEG) formulation for colonoscopy preparation using the following metrics: quality of cleansing, colonoscopy outcomes, patient/physician satisfaction, and patient tolerability. Methods The enrolled patients were randomly divided into two groups and received a single 2 L dose of either PEG (PEG group) or lactulose (Lac group). The Boston Bowel Preparation Scale (BBPS) was used for assessing the cleansing quality of the bowel preparations. Patient tolerability and adverse events were obtained through the completion of questionnaires. Results The lactulose oral solution showed superior bowel cleansing compared to PEG, as evidenced by higher BBPS scores in the Lac group for all segments of the colon (P < 0.05). The detection rates of polyps and intestinal lesions in the Lac group (30.68% and 36.36%, respectively) were significantly higher than those in the PEG group (12.50% vs. 13.63%, respectively). For the degree of satisfaction, the Lac group had significantly higher scores compared to the PEG group, as evaluated by both the patients and endoscopist. PEG was associated with an increased incidence of nausea. There were no statistical differences between the groups in terms of vomiting, abdominal pain or fullness, dizziness, unfavorable palatability, dry mouth, palpitation, tinnitus, and tongue numbness. Conclusion A single 2 L dose of a lactulose oral solution had higher efficacy, improved tolerability, and acceptable safety for bowel preparation when compared to the same volume of PEG. Thus, a lactulose oral solution may be a potential bowel-cleansing option for colonoscopy preparation.
Work system design to improve the economic performance of the firm

Purpose – The purpose of this paper is to look at job design, motivation and teamwork. As the market gets more competitive, companies must change their plan of attack on almost a daily basis. They need to answer the question: what is the best way to do business? As employers look at job design they will find that it is not the only factor that indicates how productive employees are in the workplace. Motivation also determines how much energy employees will expend, as well as what tasks will be accomplished, and in what amount of time it will be completed.Design/methodology/approach – Increasing productivity among employees is the key to a successful work group and firm. This paper will look at job design, motivation in the workplace and teamwork as they continue to be the major factors that determine the amount of work an individual does within a firm. Job design includes three main categories: job enlargement, job rotation, and job enrichment. The job characteristics model, a more recent approach to job .
Optimal experiment design for magnetic resonance fingerprinting

Magnetic resonance (MR) fingerprinting is an emerging quantitative MR imaging technique that simultaneously acquires multiple tissue parameters in an efficient experiment. In this work, we present an estimation-theoretic framework to evaluate and design MR fingerprinting experiments. More specifically, we derive the Cramér-Rao bound (CRB), a lower bound on the covariance of any unbiased estimator, to characterize parameter estimation for MR fingerprinting. We then formulate an optimal experiment design problem based on the CRB to choose a set of acquisition parameters (e.g., flip angles and/or repetition times) that maximizes the signal-to-noise ratio efficiency of the resulting experiment. The utility of the proposed approach is validated by numerical studies. Representative results demonstrate that the optimized experiments allow for substantial reduction in the length of an MR fingerprinting acquisition, and substantial improvement in parameter estimation performance.
Arabidopsis bHLH100 and bHLH101 Control Iron Homeostasis via a FIT-Independent Pathway

Iron deficiency induces a complex set of responses in plants, including developmental and physiological changes, to increase iron uptake from soil. In Arabidopsis, many transporters involved in the absorption and distribution of iron have been identified over the past decade. However, little is known about the signaling pathways and networks driving the various responses to low iron. Only the basic helix–loop–helix (bHLH) transcription factor FIT has been shown to control the expression of the root iron uptake machinery genes FRO2 and IRT1. Here, we characterize the biological role of two other iron-regulated transcription factors, bHLH100 and bHLH101, in iron homeostasis. First direct transcriptional targets of FIT were determined in vivo. We show that bHLH100 and bHLH101 do not regulate FIT target genes, suggesting that they play a non-redundant role with the two closely related bHLH factors bHLH038 and bHLH039 that have been suggested to act in concert with FIT. bHLH100 and bHLH101 play a crucial role in iron-deficiency responses, as attested by their severe growth defects and iron homeostasis related phenotypes on low-iron media. To gain further insight into the biological role of bHLH100 and bHLH101, we performed microarray analysis using the corresponding double mutant and showed that bHLH100 and bHLH101 likely regulate genes involved in the distribution of iron within the plant. Altogether, this work establishes bHLH100 and bHLH101 as key regulators of iron-deficiency responses independent of the master regulator FIT and sheds light on new regulatory networks important for proper growth and development under low iron conditions.