Miracle-dz/UniFAR-FTUs huggingface dataset:
Functional connectivity‐based identification of subdivisions of the basal ganglia and thalamus using multilevel independent component analysis of resting state fMRI

This study aimed to identify subunits of the basal ganglia and thalamus and to investigate the functional connectivity among these anatomically segregated subdivisions and the cerebral cortex in healthy subjects. For this purpose, we introduced multilevel independent component analysis (ICA) of the resting‐state functional magnetic resonance imaging (fMRI). After applying ICA to the whole brain gray matter, we applied second‐level ICA restrictively to the basal ganglia and the thalamus area to identify discrete functional subunits of those regions. As a result, the basal ganglia and the thalamus were parcelled into 31 functional subdivisions according to their temporal activity patterns. The extracted parcels showed functional network connectivity between hemispheres, between subdivisions of the basal ganglia and thalamus, and between the extracted subdivisions and cerebral functional components. Grossly, these findings correspond to cortico‐striato‐thalamo‐cortical circuits in the brain. This study also showed the utility of multilevel ICA of resting state fMRI in brain network research. Hum Brain Mapp, 2013. © 2012 Wiley Perodicals, Inc.
Highly Pathogenic Avian Influenza Virus Nucleoprotein Interacts with TREX Complex Adaptor Protein Aly/REF

We constructed a novel chicken (Gallus gallus) lung cDNA library fused inside yeast acting domain vector (pGADT7). Using yeast two-hybrid screening with highly pathogenic avian influenza (HPAI) nucleoprotein (NP) from the strain (A/chicken/Malaysia/5858/2004(H5N1)) as bait, and the Gallus gallus lung cDNA library as prey, a novel interaction between the Gallus gallus cellular RNA export adaptor protein Aly/REF and the viral NP was identified. This interaction was confirmed and validated with mammalian two hybrid studies and co-immunoprecipitation assay. Cellular localization studies using confocal microscopy showed that NP and Aly/REF co-localize primarily in the nucleus. Further investigations by mammalian two hybrid studies into the binding of NP of other subtypes of influenza virus such as the swine A/New Jersey/1976/H1N1 and pandemic A/Malaysia/854/2009(H1N1) to human Aly/REF, also showed that the NP of these viruses interacts with human Aly/REF. Our findings are also supported by docking studies which showed tight and favorable binding between H5N1 NP and human Aly/REF, using crystal structures from Protein Data Bank. siRNA knockdown of Aly/REF had little effect on the export of HPAI NP and other viral RNA as it showed no significant reduction in virus titer. However, UAP56, another component of the TREX complex, which recruits Aly/REF to mRNA was found to interact even better with H5N1 NP through molecular docking studies. Both these proteins also co-localizes in the nucleus at early infection similar to Aly/REF. Intriguingly, knockdown of UAP56 in A549 infected cells shows significant reduction in viral titer (close to 10 fold reduction). Conclusively, our study have opened new avenues for research of other cellular RNA export adaptors crucial in aiding viral RNA export such as the SRSF3, 9G8 and ASF/SF2 that may play role in influenza virus RNA nucleocytoplasmic transport.
Sex-Related Neuroanatomical Basis of Emotion Regulation Ability

Behavioral research has demonstrated that males have a higher capability of regulating their own and others' emotions than females; however, little is known about the sex-specific brain mechanisms involved in emotion regulation ability. In the present study, we used voxel-based morphometry to investigate the neural basis underlying emotion regulation ability in a large sample of young adults. Assessment of emotion regulation ability was performed using the Wong and Law Emotional Intelligence Scale. As expected, males significantly scored higher in emotion regulation ability than females did. More importantly, we found the sex differences in the neuroanatomical basis of emotion regulation ability. Males showed a stronger positive relation between emotion regulation ability and regional gray matter volume (rGMV) in the right dorsolateral prefrontal cortex. In contrast, females demonstrated a stronger positive relation between emotion regulation ability and rGMV in an anatomical cluster that extends from the left brainstem to the left hippocampus, the left amygdala and the insular cortex. The present study provides the first empirical evidence regarding the sex-linked neuroanatomical correlates of emotion regulation ability. These findings may help understand why there is a higher prevalence of affective disorders in females and maladaptive behaviors in males.
Detection of Salmonella typhi agglutinins in sera of patients with other febrile illnesses and healthy individuals.

BACKGROUND AND PURPOSE Widal test is frequently applied for the detection of Salmonella agglutinins to diagnose Salmonella enterica serotype Typhi infection. There are however a number of controversies challenging the diagnostic utility of this test. This study was performed to determine the prevalence of Salmonella agglutinins in patients with other febrile illnesses and healthy blood donors. MATERIALS AND METHODS Sera from 50 healthy blood donors were compared for the presence of Salmonella agglutinins in various groups of patients with other febrile illnesses using Widal test in the division of Serology and Immunology at King Khalid University Hospital, Riyadh. The patient groups of other febrile illnesses included infections with Beta-hemolytic streptococcus (n = 50), Brucella (n = 46), Helicobacter pylori (n = 24), Treponema pallidum (n = 30), Toxoplasma (n = 44), and other parasites (n = 20). RESULTS Majority of the patients and normal individuals were tested positive for Widal test at dilution of less than 1 : 40 both for the O (62.5%) and H (64.6%) antigen. A decreasing trend in Widal reactivity was observed with increasing dilutions of the serum samples. At 1 : 160 titer, which is generally considered as a cut off point for positive Widal test, 6.4 and 11% individuals had positive Widal test for O and H Salmonella antigens, respectively. CONCLUSION Detection of a significant number of positive Widal tests in conditions where it is expected to be nonreactive appears to be a serious problem in making a correct diagnosis of typhoid fever, thus challenging the diagnostic utility of the Widal test.
Consumer Trust in an Internet Store: A Cross-Cultural Validation

Many have speculated that trust plays a critical role in stimulating consumer purchases over the Internet. Most of the speculations have rallied around U.S. consumers purchasing from U.S.–based online merchants. The global nature of the Internet raises questions about the robustness of trust effects across cultures. Culture may also affect the antecedents of consumer trust; that is, consumers in different cultures might have differing expectations of what makes a web merchant trustworthy. Here we report on a cross-cultural validation of an Internet consumer trust model. The model examined both antecedents and consequences of consumer trust in a Web merchant. The results provide tentative support for the generalizability of the model.
The cause of "acid-crash" and "acidogenic fermentations" during the batch acetone-butanol-ethanol (ABE-) fermentation process.

Experiments were performed to determine the cause of "acid crash", a phenomenon which occasionally occurs in pH-uncontrolled batch fermentations resulting in premature cessation of ABE (acetone butanol) production. The results indicate that "acid crash" occurs when the concentration of undissociated acids in the broth exceeds 57 - 60 mmol/l. Prevention can be achieved by introducing some limited pH control to minimize the concentration of undissociated acids or by slowing the metabolic rate, and thus the rate of acid production, by, for example, lowering the fermentation temperature. "Acidogenic fermentations", which occur when batch fermentations are performed at pH values close to neutrality, are due to rapid production of acids followed by inhibition of solventogenesis when the total acid concentration reaches 240 - 250 mmol/l. Solventogenesis can be achieved at these pH values by lowering the glucose uptake rate / acid production rate by use of e.g. elevated glucose or lowered yeast extract concentrations in the growth medium.
Effects of emotional intelligence on academic achievement in the alternative high school classroom

This study examines the impact of emotional intelligence, academic self-efficacy in science and technology, and family background on academic achievement of alternative high school students. Gender, age, learning style, and ethnicity of the student are analyzed to determine any moderator effect on these relationships. Seventy-five students, ages 14 to19, who attend a public alternative high school were surveyed. Analysis of the data revealed a positive relationship for males between self-efficacy in STEM classes and family background (support) and their academic achievement in science class. A positive relationship was shown between self-efficacy in STEM classes and academic achievement, between self-efficacy in STEM classes and academic achievement in science class for White/non-Hispanic and Native American students, and between family background and academic achievement in science class for White/non-Hispanic, Latino/Hispanic, and Native American students. There was a positive relationship between emotional intelligence and academic achievement in science class for Latino/Hispanic and African-American students. Kinesthetic, auditory, and visual learning styles demonstrated positive relationships as moderators on the independent variables. Students that were 17 and 19 years of age had moderating effects on the independent variables. EMOTIONAL INTELLIGENCE v
The effect of auditory occlusion on TAT responses of institutionalized delinquent, adolescent boys

The purpose of this experiment was to examine the effect of not hearing one's voice on certain aspects of verbalization among delinquent boys. White noise masking(WNM) was used to occlude subjects' own voices from themselves. Forty(40) subjects from the John G. Richards School for Boys, Columbia, South Carolina, were selected and placed at random into four sample groups of ten(10) boys each. Two of these groups were experimental and two control. One experimental group and one control group were pretested and the others were not. The task of the subjects was to respond verbally to selected Thematic Apperception Test cards with the subjects in the experimental groups responding under WNM conditions.
Strategic Information Systems Planning As A Dynamic Capability: Insights From An Agent-Based Simulation Study

Strategic information systems planning (SISP) helps companies to align their IT systems with their business plans. It claims to enable companies to gain competitive advantages. The resource-based view (RBV) of the firm might help to understand how and why. Drawing on prior research we believe that strategic IT planning is a dynamic capability, enabling a firm to reconfigure its resource configuration as theorized by Eisenhardt and Martin. However, this assumption has not been tested sufficiently yet. Using an agent-based simulation (ABS), this study tests to what extent strategic IT planning as a dynamic capability enables a firm to gain competitive advantages. We model an industry of companies striving for competitive advantages by optimizing their IT resources using dynamic capabilities. Given our operationalization of Eisenhardt and Martin’s framework, we however cannot support the notion of SISP as a dynamic capability. Interestingly, companies in the simulation fail to realize competitive advantages because they do not anticipate competitors’ moves and environmental uncertainty, an aspect deserving more attention in the resource-based view. These results and further research it may encourage demonstrate the potential of ABS for refining theories.
Modeling real requirements for cooperative software development: A case study

GENESIS is an Open Source distributed platform supporting cooperative software engineering. All requirements concerning cooperation, collaboration, and coordination have been derived from actual user needs, collected from some of the largest software development companies in the European scenario; moreover, an integrated approach, merging both process-centered and product-centered ones, has been adopted. In this paper we present such two basic facets of GENESIS, which constitute the main achievements of the project, and therefore provide an innovative platform to be experienced both by practitioners and researchers.
Presentation, Prognostic Factors and Patterns of Failure in Adult Rhabdomyosarcoma

Purpose: The purpose of our study is to retrospectively review our institutional experience with adult rhabdomyosarcoma (RMS) to determine presentation, prognostic factors and patterns of failure in this disease. Materials and Methods: All patients ≥ 16 years with a diagnosis of rhabdomyosarcoma were retrospectively reviewed. Tumors were classified according to the Intergroup Rhabdomyosarcoma Study (IRS) staging and grouping system. Median follow-up for surviving patients was 12.5 years. Results: A total of 39 patients (23 male, 16 female) were seen at our institution from 1961 to 1999. Median age was 45 years, and age distribution showed a bimodal peak at the late teens to twenties and later in the sixties. Tumor in the extremity was most common as seen in 15 (39%); this was followed by head and neck in 11 (28%), genitourinary in eight (20%), trunk/retroperitoneum in four (10%) and other in one (3%). Tumor stage was T1 in 21 (52%) while 26 (67%) were > 5 cm in size. Pleomorphic histology was most common (36%) and increased in incidence according to age category: 0% for ages 16–19, 27% for ages 20–49 and 60% for ages ≥ 50 years old (P < 0.01). The median survival for the entire population was 2.25 years with a 5-year overall survival rate of 35%. Multivariate analysis identified early IRS stage (P < 0.001), non-embryonal histology (P < 0.009), favorable site (P = 0.024), female gender (P = 0.034), early T-stage (P = 0.034) and absence of nodal metastases (P = 0.037) as predictors of a better survival. The 5-year progression-free survival rate was 21%. Female gender (P = 0.002), non-embryonal histology (P = 0.009), early IRS stage (P = 0.02) and early T stage (P = 0.033) were found on multivariate analysis to predict for improved progression-free survival. The 5-year local control rate was 51%, and multivariate analysis found that only early T-stage was predictive of better local control (P = 0.045). Five of six Group II patients and five of eight Group III patients who received radiotherapy (RT) were locally controlled. Only one of five Group III patients was locally controlled without RT. Conclusions: The overall prognosis of adult RMS is worse than reported in children, but age criteria within the adult population did not further classify outcome. RT is an effective local modality providing local control in almost all Group II and majority of Group III patients.
Visualization for Software Product Lines: A Systematic Mapping Study

Software Product Lines (SPLs) are families of related systems whose members are distinguished by the set of features they provide. Over two decades of research and practice can attest to the substantial benefits of applying SPL practices such as better customization, improved software reuse, and faster time to market. Typical SPLs involve large number of features which are combined to form also large numbers of products, implemented using multiple and different types of software artifacts. Because of the sheer amount of information and its complexity visualization techniques have been used at different stages of the life cycle of SPLs. In this paper we present a systematic mapping study on this subject. Our research questions aim to gather information regarding the techniques that have been applied, at what stages, how they were implemented, and the publication fora employed. Our goal is to identify common trends, gaps, and opportunities for further research and application.
INCIDENCE AND TIME TREND OF CAESAREAN SECTION IN MATERNITY AND CHILD HOSPITAL IN BASRAH

This is a cross sectional record based study aimed at studying the incidence and trend of caesarian section in Basrah Maternity and Child Hospital during the period extending from 1997-2003. In addition a sample of 150 women who were delivered by caesarean section in the same hospital over the period extending from the 1st of June to the 15th of September 2004 were also included to study the indication for Caesarean section. The results of the study showed that, the overall incidence rate of caesarean section over the period 1997-2003 was 15.25%. The annual incidence of caesarean section in the 7 years period showed a steady increase from 10.8% to 21.3%. The commonest indication for elective caesarean section was previous two scars (33%), while for emergency cases abnormal presentation and lie was the commonest indication (27%). INTRODUCTION aesarean section C/S is a major obstetric operation that remained a matter of controversy for several years and gained popularity in recent decades with a dramatic rise in the rate of caesarean deliveries all over the world. This trend is more apparent in the developed than the developing countries. The rising number of indications for C/S, the use of fetal monitors, the current medico legal climate, the importance of avoiding damage to the baby, and the increased safety of the C/S itself are some of the reasons cited for this trend. Mc Garry in his review in 1987 found that over the preceding fifteen years, the caesarean section rate has increased in many countries and in different rates. The rate of caesarean section deliveries in the United State has increased from 5.5% in 1970 to 22.7% in 1985. During 1984 caesarean delivery became the number one hospital operative procedure in USA and accounted for 21% of deliveries of all live births. In 1988 the figure climbed to 24.7% and it was projected then to reach 30% in year 2000. In England, the C/S rate doubled from 4% in 1970 to 9% in 1980, the rate almost doubled again during the 1990s with an estimated rate of 16% in 1995 and 19% in 1999. In Jordan during a six-year review from 1991 to 1997 at Queen Alia Military Hospital, Amman, the incidence rate was 7.7 %. In AlShaty Hospital in Jedda, Saudi Arabia the C/S rate was found to be 9.9% during 1994. However, in Basrah, a study was carried out in Al-Tahreer Hospital during the year 2000, found a very high incidence rate of C/S at 24 %. The present study was carried out to study the incidence, trend and the main indications of C/S in Basrah Maternity and Child Hospital.
On the Relationship between a Giant Radio Galaxy MSH 05-22 and the Ambient Large-Scale Galaxy Structure

We present a comparison of the properties of a giant radio galaxy and the ambient intergalactic medium, whose properties are inferred from the large-scale distribution in galaxies. The double lobes of the radio galaxy MSH 05-22 are giant—1.8 Mpc projected linear size—and interact with the environment outside the interstellar medium and coronal halo associated with the host galaxy. The radio lobes appear to be relicts, and the double structure is asymmetric. We have examined the large-scale structure in the galaxy distribution surrounding the radio source. The host galaxy of MSH 05-22 is associated with a small group that lies close to the boundary of sheetlike and filamentary density enhancements, and adjacent to a void. Assuming that the galaxies trace gas, the asymmetries in the radio morphology in this case study appear related to the anisotropy in the medium. However, the observed overdensities and structure formation models for the heating of the intergalactic medium (IGM) suggest a density-temperature product for the IGM environment that is an order of magnitude below that expected from the properties of the radio source. The discordance suggests that even sources like MSH 05-22, which are observed in the relatively low-density IGM environment associated with the filamentary large-scale structure and have multiple signatures of being relicts, may be overpressured and evolving toward an equilibrium relaxed state with the ambient IGM. Alternately, it is speculated that astrophysical feedback originating in galaxy overdensities observed 1-2 Mpc to the north and northeast of MSH 05-22 might be the mechanism for the heating of the ambient IGM gas.
First Impressions, Team Satisfaction and Work-Related Flow: A Multilevel Analysis

First impressions of fellow team members, as well as individual satisfaction with one’s team, are each related to work-related flow experiences but they are rarely studied in combination. To address this gap we collected measures of all three in a laboratory study of dyadic teams (N=55). First impressions were assessed prior to the start of a management simulation task, and both team satisfaction and work-related flow were assessed afterwards. Hierarchical linear modeling revealed that measures of team satisfaction at both the individual and team levels were predictive of work-related flow experiences; an interaction between the discrepancy in first impression ratings within each team and individual ratings of team satisfaction was also found. Findings suggest that discrepancies in first impressions interact with team satisfaction in ways that may negatively impact work-related flow experiences, which in turn has the potential to impair team formation and performance effectiveness of ad hoc teams.