Miracle-dz/UniFAR-FTUs huggingface dataset:
The Motivation to Comply with Internal or External Moral Expectations: Is Just One Motivation Enough?

Although researchers have shown how the need to reduce internal discrepancies between one’s current level of morality and one’s moral standard and the need to reduce negative social judgment drive prosocial behaviors, it remains unclear if the presence of both these motivations has additive effects on prosocial behaviors. I propose that the answer is no: people operate on a sufficient motivation principle when deciding to behave prosocially, that is, they should be equally prosocial whether one or both motivations are present. I further argue that individual differences in public (PUSC) and private (PRSC) self-consciousness affect people’s attention to the two types of motivations. High PUSC people are concerned about what others think of them. So, when social judgment is present, they should be equally prosocial regardless of internal discrepancies. High PRSC people are aware of their internal attitudes and moral standards. So, whether social judgment is present, they should be more prosocial in the presence than absence of internal discrepancies. To test these hypotheses, the presence of internal discrepancies and social judgment was manipulated and their effects on money allocation in a Dictator Game examined. Results did not support the sufficient motivation principle. However, a PUSC x Internal Discrepancies x Social Judgment interaction was observed. Contrary to predictions, high PUSC people were not uniformly prosocial in the presence of social judgment. Instead, they were less prosocial in the presence than absence of internal discrepancies. These findings suggest that mechanisms other than those hypothesized may have influenced people’s prosocial behavior. Although the sufficient motivation principle and the expected moderating effects of PUSC and PRSC were not supported, this could be due to the many limitations of the study. Future studies should take these limitations into account to provide a more conclusive finding.
Preparation and in vitro/in vivo evaluation of dextran matrix tablets of budesonide in experimental ulcerative colitis in rats

Budesonide is an anti-inflammatory drug of choice for treatment of ulcerative colitis which affects the rectum and a part of or the entire colon. Delivery of budesonide specifically to the colon would increase the efficacy of the drug and reduce the side-effects. The aim of this study was to develop an oral matrix system formulation for budesonide to deliver the major part of the drug to the colon for treatment of ulcerative colitis that has not been reported before. Directly compressed matrix tablets were prepared using different molecular weights of dextran and three ratios of drug-to-polymer. The physical properties of the tablets including weight variation, hardness, content uniformity, and release profile in HCl 0.1 N, phosphate buffer pH 7.4 and 6.8 containing 4% rat caecal and colonic contents were studied. The efficacy of the desired formulation was also evaluated against acetic acid-induced colitis in rats. Physical properties of the tablets were in the ranges recommended by official references. More than 10% of the drug was released in HCl 0.1 N and pH 7.4, while a very drastic increase was observed after exposure to pH 6.8 containing rat caecal contents. The efficacy of the selected formulation against rat-induced colitis was also increased in comparison to the non-targeted formulation of budesonide. In conclusion, matrix tablets with a 1:10 drug-to-dextran ratio with high molecular weight could deliver the drug specifically to the colon and are promising for treatment of ulcerative colitis.
A randomised placebo-controlled trial of topical steroid in presumed viral conjunctivitis

We read with interest the article by Tan et al. We congratulate the authors for emphasising the need for meticulous examination of the peripheral retina to look for retinal breaks after pars plana vitrectomy (PPV). We would like to add some comments to augment this fine study. 1. We did not completely understand what the authors mean by ‘intensified search strategy’ and ‘enhanced 3608 internal search’. Are they proposing any new technique which is different from what is a common practice? It is a common practice to check for peripheral retinal breaks after PPV and we have been doing this in a similar fashion with the help of the Binocular Indirect Ophthalmol Microscope (BIOM) for the last 10 years. This is in fact a routine teaching in all surgical retina fellowship programmes. 2. The authors reported a very high incidence of retinal breaks. Breaks were seen in 53 eyes (24.3%) out of 218 eyes. Thirty-eight eyes (17.4%) were sclerotomy-related breaks and 21 eyes (9.6%) had breaks elsewhere. We are not questioning the surgical technique, but we feel that there should be some explanation for such a high incidence of retinal breaks. It is possible that some of the retinal breaks were pre-existing breaks without signs of pigmentation, etc. The authors do admit that not all the cases were examined by indirect ophthalmoscope and sclera depression pre-operatively. 3. In many cases, after PPV it is difficult to examine the retinal periphery with BIOM as recommended by the authors. Peripheral view, at the end of surgery, is difficult in these cases due to cataract, posterior capsular opacification or corneal haze. In these situations, an ocular endoscope is a very valuable instrument. We have been using this endoscope for vitreoretinal surgery and have demonstrated its effectiveness in examining sclerotomy-related complications (eg, vitreous traction, retinal pull, retinal break). An endoscope enables a surgeon to view and simultaneously laser the break. One of the authors of the article, Dr de Smet, is a well-known proponent of the ocular endoscope. We are sure he would also agree that any intensified search strategy or enhanced 3608 internal search for peripheral breaks would be augmented by the use of an ophthalmic endoscope.
Frequency of conservatively managed traumatic acute subdural haematoma changing into chronic subdural haematoma.

BACKGROUND Traumatic brain injury represents a significant cause of mortality and permanent disability in the adult population. Acute subdural haematoma is one of the conditions most strongly associated with severe brain injury. Knowledge on the natural history of the illness and the outcome of patients conservatively managed may help the neurosurgeon in the decision-making process. METHODS We prospectively analysed 27 patients with age ranges 15-90 years, in whom a CT scan diagnosis of acute subdural haematoma was made, and in whom craniotomy for evacuation was not initially performed, to the neurosurgery department of Ayub Teaching Hospital Abbottabad (2008-2011). Patients with deranged bleeding profile, anticoagulant therapy, chronic liver disease, any other associated intracranial abnormalities, such as cerebral contusions, as shown on CT, were excluded from this study. All patients were followed by serial CT scans, and a neurological assessment was done. RESULTS There were 18 male and 9 female patients, Cerebral atrophy was present in over half of the sample. In 22 of our patients, the acute subdural haematoma resolved spontaneously, without evidence of damage to the underlying brain, as shown by CT or neurological findings. Four patients subsequently required burr hole drainage for chronic subdural haematoma. In each of these patients, haematoma thickness was greater than 10 mm. The mean delay between injury and operation in this group was 15-21 days. Among these patients 1 patient required craniotomy for haematoma removal due to neurological deterioration. CONCLUSION Certain conscious patients with small acute subdural haematomas, without mass effect on CT, may be safely managed conservatively, but due to high risk of these acute subdural haematoma changing into chronic subdural haematoma these patients should be reinvestigated in case of neurological deterioration.
Nitrogen Limitation Promotes Accumulation and Suppresses Release of Cylindrospermopsins in Cells of Aphanizomenon Sp.

As the biosynthesis of cylindrospermopsin (CYN) is assumed to depend on nitrogen availability, this study investigated the impact of nitrogen availability on intra- and extracellular CYN and deoxy-CYN (D-CYN) contents in three Aphanizomenon strains from temperate waters. Nitrogen deficient (−N) cultures showed a prolonged growth phase and intracellular toxin accumulation by a factor of 2–6. In contrast, cultures with additional nitrate supply (+N) did not accumulate CYN within the cells. Instead, the maximum conceivable CYN release estimated for dead cells (identified by SYTOX® Green staining) was much lower than the concentrations of dissolved CYN actually observed, suggesting these cultures actively release CYN from intact cells. Furthermore, we found remarkably altered proportions of CYN to D-CYN: as batch cultures grew, the proportion of D-CYN increased by up to 40% in +N medium, whereas D-CYN remained constant or decreased slightly in −N medium. Since +N cultures showed similar toxin patterns as −P cultures with increased extracellular CYNs and higher proportion of D-CYN we conclude that nitrogen limitation may affect the way the cells economize resources, especially the yield from phosphorus pools, and that this has an impact on CYN production and release. For water management, these result imply that nutrient availability not only determines the abundance of potentially CYN-producing cyanobacteria, but also the amount of extracellular CYNs (challenging drinking-water treatment) as well as the ratio of D-CYN to CYN (affecting toxicity).
THE ASSOCIATION OF GENE POLYMORPHISMS WITH ATHLETE STATUS IN UKRAINIANS

Athletic performance is a polygenic trait influenced by both environmental and genetic factors. Objective To investigate individually and in combination the association of common gene polymorphisms with athlete status in Ukrainians. Methods A total of 210 elite Ukrainian athletes (100 endurance-oriented and 110 power-orientated athletes) and 326 controls were genotyped for ACE I/D, HIF1A Pro582Ser, NOS3 –786 T/C, PPARA intron 7 G/C, PPARG Pro12Ala and PPARGC1B Ala203Pro gene polymorphisms, most of which were previously reported to be associated with athlete status or related intermediate phenotypes in different populations. Results Power-oriented athletes exhibited an increased frequency of the HIF1A Ser (16.1 vs. 9.4%, P = 0.034) and NOS3 T alleles (78.3 vs. 66.2%, P = 0.0019) in comparison with controls. Additionally, we found that the frequency of the PPARG Ala allele was significantly higher in power-oriented athletes compared with the endurance-oriented athletes (24.7 vs. 13.5%; P = 0.0076). Next, we determined the total genotype score (TGS, from the accumulated combination of the three polymorphisms, with a maximum value of 100 for the theoretically optimal polygenic score) in athletes and controls. The mean TGS was significantly higher in power-oriented athletes (39.1 ± 2.3 vs. 32.6 ± 1.5; P = 0.0142) than in controls. Conclusions We found that the HIF1A Ser, NOS3 T and PPARG Ala alleles were associated with power athlete status in Ukrainians.
Leaving matters: The nature, evolution and effects of emigration policies

Debates on migration policies are strongly focused on immigration control, revealing a general receiving-country bias in migration research. To fill this gap, this paper reviews the nature, evolution and effects of emigration policies. Only a declining number of strong, authoritarian states with closed economies are willing and capable of imposing blanket exit restrictions. Paradoxically, while an increasing number of, particularly developing, countries aspire to regulate emigration, their capability to do so is fundamentally and increasingly limited by legal, economic and political constraints. The attitude of states is often intrinsically ambiguous, as they face a complex trade-off between the perceived economic and political costs and benefits of emigration, in which who leaves greatly matters. This motivates states to adopt more subtle policies to encourage or discourage migration of particular skill, gender, age, regional or ethnic groups. Since state policies simultaneously constrain and enable migration of different groups to different destinations, states can play a significant role in structuring emigration through influencing the (initial) composition and spatial patterns of emigration. Even ‘laissez-faire’ policies require active state agency to create the structural conditions for ‘free’ emigration. However, the effect of emigration policies on overall volume and long-term trends of migration seems limited or even insignificant because of the preponderance of other economic, social and cultural migration determinants. This review reveals the need to improve insights into how states and policies shape migration processes in their interaction with other migration determinants in sending and receiving countries.
Peptide Fractions Obtained from Rice By-Products by Means of an Environment-Friendly Process Show In Vitro Health-Related Bioactivities

Recently, the isolation of new health-related bioactive molecules derived from agro-food industrial by-products by means of environment-friendly extraction processes has become of particular interest. In the present study, a protein by-product from the rice starch industry was hydrolysed with five commercial proteolytic enzymes, avoiding the use of solvents or chemicals. The digestion processes were optimised, and the digestates were separated in fractions with four different molecular weight ranges by using a cross-flow membrane filtration technique. Total hydrolysates and fractions were tested in vitro for a wide range of biological activities. For the first time rice-derived peptides were assayed for anti-tyrosinase, anti-inflammatory, cytotoxicity and irritation capacities. Antioxidant and anti-hypertensive activities were also evaluated. Protamex, Alcalase and Neutrase treatments produced peptide fractions with valuable bioactivities without resulting cytotoxic or irritant. Highest levels of bioactivity were detected in Protamex-derived samples, followed by samples treated with Alcalase. Based on the present results, a future direct exploitation of isolated peptide fractions in the nutraceutical, functional food and cosmetic industrial fields may be foreseen.
'Between two lives' : parenting and impacts on academic, professional achievements and socio-emotional outcomes for British-Ghanaians

Research undertaken within the Sociology of Education frequently highlights concerns about the underachievement of Black students in education and, later, within the labour market. Yet, there are a number of shortcomings associated with research in this area. Firstly, there is a tendency to homogenise the achievement levels of all Black students. Thus observations made about the outcomes of African-Caribbean students are often applied to all other Black groups. When distinctions between African and African Caribbean groups have been made, the achievement levels of students from different African backgrounds are often merged, creating a misleading impression of their different academic outcomes. Secondly, studies seeking to provide explanations for the low attainment levels of Black students are often critical of life within Black families, in particular their assumed use of an „authoritarian‟ parenting style, which is seen as creating psychological problems in children and as hindering their achievement. Effectively, such notions serve to pathologise Black families in Britain. This thesis presents a critique of existing studies concerning Black families in Britain and the academic achievement of Black (African) children, and also seeks to address existing gaps in the knowledge about Black Africans residing in Britain. Life history interviews were conducted with 25 British-Ghanaians who have achieved highly in their academic and professional pursuits. The findings suggest that not all parents adopted an „authoritarian‟ approach when raising their children, and that those who did were influenced by their own socialisation experiences in Ghana. While some respondents experienced some socio-emotional problems resulting from their „authoritarian‟ socialisation, these were generally resolved and did not have a long-term impact on their attainment. The thesis also suggests that the use of discipline, associated with this parenting style, may have had some beneficial effects in relation to respondents‟ academic and professional outcomes.
Attitudes towards Advance Care Planning and Healthcare Autonomy among Community-Dwelling Older Adults in Beijing, China

Objectives. To investigate the preferences of ACP and healthcare autonomy in community-dwelling older Chinese adults. Methods. A community-based cross-sectional study was conducted with older adults living in the residential estate of Chaoyang District, Beijing. Results. 900 residents were enrolled. 80.9% of them wanted to hear the truth regarding their own condition from the physician; 52.4% preferred to make their own healthcare decisions. Only 8.9% of them preferred to endure life-prolonging interventions when faced with irreversible conditions. 78.3% of the respondents had not heard of an ACP; only 39.4% preferred to document in an ACP. Respondents with higher education had significantly higher proportion of having heard of an ACP, as well as preferring to document in an ACP, compared to those with lower education. Those aged <70 years had higher proportion of having heard of an ACP, as well as refusing life-prolonging interventions when faced with irreversible conditions, compared to those aged ≥70 years. Conclusions. Although the majority of community-dwelling older Chinese adults appeared to have healthcare autonomy and refuse life-prolonging interventions in terms of end-of-life care, a low level of “Planning ahead” awareness and preference was apparent. Age and education level may be the influential factors.
MEMTUNE: Dynamic Memory Management for In-Memory Data Analytic Platforms

Memory is a crucial resource for big data processing frameworks such as Spark and M3R, where the memory is used both for computation and for caching intermediate storage data. Consequently, optimizing memory is the key to extracting high performance. The extant approach is to statically split the memory for computation and caching based on workload profiling. This approach is unable to capture the varying workload characteristics and dynamic memory demands. Another factor that affects caching efficiency is the choice of data placement and eviction policy. The extant LRU policy is oblivious of task scheduling information from the analytic frameworks, and thus can lead to lost optimization opportunities. In this paper, we address the above issues by designing MEMTUNE, a dynamic memory manager for in-memory data analytics. MEMTUNE dynamically tunes computation/caching memory partitions at runtime based on workload memory demand and in-memory data cache needs. Moreover, if needed, the scheduling information from the analytic framework is leveraged to evict data that will not be needed in the near future. Finally, MEMTUNE also supports task-level data prefetching with a configurable window size to more effectively overlap computation with I/O. Our experiments show that MEMTUNE improves memory utilization, yields an overall performance gain of up to 46%, and achieves cache hit ratio of up to 41% compared to standard Spark.
Correlated Topic Vector for Scene Classification

Scene images usually involve semantic correlations, particularly when considering large-scale image data sets. This paper proposes a novel generative image representation, correlated topic vector, to model such semantic correlations. Oriented from the correlated topic model, correlated topic vector intends to naturally utilize the correlations among topics, which are seldom considered in the conventional feature encoding, e.g., Fisher vector, but do exist in scene images. It is expected that the involvement of correlations can increase the discriminative capability of the learned generative model and consequently improve the recognition accuracy. Incorporated with the Fisher kernel method, correlated topic vector inherits the advantages of Fisher vector. The contributions to the topics of visual words have been further employed by incorporating the Fisher kernel framework to indicate the differences among scenes. Combined with the deep convolutional neural network (CNN) features and Gibbs sampling solution, correlated topic vector shows great potential when processing large-scale and complex scene image data sets. Experiments on two scene image data sets demonstrate that correlated topic vector improves significantly the deep CNN features, and outperforms existing Fisher kernel-based features.
Impact of cellular microenvironment and mechanical perturbation on calcium signalling in meniscus fibrochondrocytes.

Mechanical signals regulate a multitude of cell functions and ultimately govern fibrous tissue growth, maintenance and repair. Such mechanotransduction processes often involve modulation of intracellular calcium concentration ([Ca2+]i). However, most studies interrogate these responses in cells in simplified culture systems, thereby removing potentially important inputs from the native extracellular microenvironment. The objective of this study was to test the hypothesis that the intracellular calcium response of meniscus fibrochondrocytes (MFCs) is dependent on both the microenvironmental context in which this perturbation is applied and on the tensile deformation. Using a custom micro-mechanical tester mounted on a confocal microscope, intracellular calcium activity in MFCs in response to incremental tissue strains (0, 3, 6 and 9 %) was monitored in situ (i.e., in the native tissues) on MFC-seeded aligned scaffolds and MFC-seeded silicone membranes. The [Ca2+]i regulation by MFCs within the native meniscus tissue microenvironment was considerably different from [Ca2+]i regulation by MFCs on either aligned nanofibrous scaffolds or flat silicone membranes. Additionally, increasing levels of tensile deformation resulted in a greater number of responding cells, both in situ and in vitro, while having no effects on temporal characteristics of [Ca2+]i signalling. Collectively, these findings have significant implications for mechanobiology of load-bearing fibrous tissues and their responses to injury and degeneration. In addition, from a tissue engineering perspective, the findings establish cellular benchmarks for maturing engineered constructs, where native tissue-like calcium mechano-regulation may be an important outcome parameter to achieve mechanical functionality comparable to native tissue.
Performance of Source Nursary of Pollen Parent and Cms Lines of Brassica napus L.

The study was conducted with the objective to know the performance of floral and yield characteristics of pollen and CMS parent. Significant variation was observed for flowering and yield contributing characteristics among two CMS lines (Z1 and Z2) and 21 pollen parents. The pollen parent Nap2019 was found as early flowering whereas the parent Nap2013 was the late for first flowering. The highest length of anther was found in Nap9907 and short anther in Nap9905. Slender anther was produced by the genotype Nap2037 and bold anther was produced by the genotype Nap9907. Length of filament was the highest in Nap2012 and the lowest in Nap0130. For yield contributing characteristics, the genotype Nap9906 matured earlier than all other genotypes while the maximum duration took by Nap2013. The longest inflorescence was found in the genotype Nap2001 and the smallest in Nap9906. The highest number of siliqua per plant was counted in Nap2066 and it was the lowest in