Miracle-dz/UniFAR-FTUs huggingface dataset:
Hostility and perceived social support: interactive effects on cardiovascular reactivity to laboratory stressors

Background: Previous research has identified trait hostility and social isolation as possible psychosocial risk factors for coronary heart disease (CHD). However, few studies have examined hostility and social support simultaneously to determine their independent and possible interactive relations with CHD and disease-promoting mechanisms.Purpose: Hypotheses derived from a general interpersonal model were tested in a study examining trait hostility and perceived social support as predictors of cardiovascular reactivity to laboratory stressors.Methods: Healthy college students (53 men, 55 women) performed speech and mental arithmetic tasks while blood pressure and heart rate were monitored.Results: There was an interactive effect of hostility and perceived social support on systolic and diastolic blood pressure (SBP and DBP) reactivity. Higher hostility scores were associated with greater SBP reactivity for participants who were high in perceived social support; whereas for those with low social support scores, greater hostility was associated with somewhat less SBP reactivity. The same pattern was obtained for DBP, but only during the speech task.Conclusions: These findings encourage further research conceptualizing trait hostility within a general interpersonal framework that calls attention to both positive and negative person-environment transactions.
Prenatal care and child growth and schooling in four low- and medium-income countries

Background The effectiveness of prenatal care for improving birth and subsequent child outcomes in low-income countries remains controversial, with much of the evidence to date coming from high-income countries and focused on early-life outcomes. We examined associations between prenatal care visits and birth weight, height-for-age at 24 months and attained schooling in four low- and middle-income countries. Methods We pooled data from prospective birth-cohort studies from Brazil, Guatemala, Philippines and South Africa. We created a prenatal care utilization index based on the number and timing of prenatal visits. Associations were examined between this index and birth weight, height-for-age at 24 months, and highest attained schooling grade until adulthood. Results Among 7203 individuals in the analysis, 68.9% (Philippines) to 96.7% (South Africa) had at least one prenatal care visit, with most having at least four visits. Over 40% of Brazilians and Guatemalans had their first prenatal visit in the first trimester, but fewer Filipinos (13.9%) and South Africans (19.8%) did so. Prenatal care utilization was not significantly associated with birth weight (p>0.05 in pooled data). Each unit increase in the prenatal care utilization index was associated with 0.09 (95% CI 0.04 to 0.15) higher height-for-age z-score at 24 months and with 0.26 (95% CI 0.17 to 0.35) higher schooling grades attained. Although there was some heterogeneity and greater imprecision across sites, the results were qualitatively similar among the four different populations. Conclusions While not related to birth weight, prenatal care utilization was associated with important outcomes later in life, specifically higher height-for-age at 24 months and higher attained school grades. These results suggest the relevance of prenatal care visits for human capital outcomes important over the lifecycle.
Prolonged hospitalization, primary refractory disease, performance status and age are prognostic factors for survival in patients with diffuse large B-cell lymphoma and transformed indolent lymphoma undergoing autologous stem cell transplantation

Abstract In patients with relapsed diffuse large B-cell lymphoma (DLBCL), high-dose chemotherapy followed by autologous stem cell transplantation (ASCT) is standard treatment. Here, we aim to identify factors associated with survival in patients undergoing ASCT. A total of 369 patients with relapsed DLBCL undergoing ASCT from 2000 to 2012 were identified in the Danish National Lymphoma Registry. Information on clinical and socioeconomic factors was obtained from medical records and national registries. Factors associated with survival were assessed using a Cox’s proportional hazards model. Median overall survival was 6.8 years, median progression-free survival was 2.6 years, and treatment-related mortality at Day 100 was 6%. Factors associated with a significant adverse impact on survival were age, primary refractory disease, prolonged hospitalization during salvage treatment, and performance status >0 prior to conditioning therapy. Reconsideration of ASCT for those patients may be required in order to select the right patients for this toxic procedure.
n-Double Scroll Hypercubes in 1-D CNNs

Unidirectional and diffusive coupling of identical n-double scroll cells in a one-dimensional cellular neural network is studied. Weak coupling between the cells leads to hyperchaos, with n-double scroll hypercube attractors observed in the common state subspace of the cells. Individually the cells remain behaving as n-double scrolls. The n-double scroll hypercubes are filled with multiple scrolls. Their birth goes through the mechanism of intermittency.
Sexual Assault Disclosure: The Effect of Victim Race and Perpetrator Type on Empathy, Culpability, and Service Referral for Survivors in a Hypothetical Scenario

The aftermath of sexual assault warrants further attention surrounding the responses provided by those to whom survivors disclose, especially when perpetrator type or victim race may affect whether the bystander response is supportive or attributes culpability to the victim. Disclosure responses have significant consequences for survivors’ posttrauma mental health and formal help-seeking behavior. The current study used a sample of 348 self-report, paper-and-pencil surveys administered during the fall 2015 semester to a purposive sample of undergraduate students with a mean age of 20.94 years old at a midsized, Southern public university. Survey design included a randomly assigned 2 × 2 hypothetical sexual assault disclosure vignette. The objective of the study was to assess the effect of perpetrator type (stranger vs. acquaintance) and victim race (White vs. Black) on empathic concern, culpability attributions, and resource referral. Between-subjects factorial ANOVA and multivariate ordinary least squares (OLS) regression models were estimated to identify the role of vignette manipulations, participant-sexual victimization history, and rape myth acceptance on empathy, culpability, and resource referral for the sexual assault survivor portrayed in the vignette. Multivariate analyses included main effects and moderation models. Findings revealed increased culpability and decreased resource referral for victims of acquaintance rape as compared with stranger rape, independent of victim race. Although no direct victim race effects emerged in the multivariate analyses, race moderated the effect of culpability on resource referral indicating culpability attributions decreased resource referral, but only when the victim was Black . Implications from the results presented here include a continued focus on bystander intervention strategies, empathy-building techniques, and educational programming targeting potential sexual assault disclosees and race stereotypes that disadvantage victims of color.
Role of AP‐endonuclease (Ape1) active site residues in stabilization of the reactant enzyme‐DNA complex

Apurinic/apyrimidinic endonuclease 1 (Ape1) is an important metal‐dependent enzyme in the base excision repair mechanism, responsible for the backbone cleavage of abasic DNA through a phosphate hydrolysis reaction. Molecular dynamics simulations of Ape1 complexed to its substrate DNA performed for models containing 1 or 2 Mg2+‐ions as cofactor located at different positions show a complex with 1 metal ion bound on the leaving group site of the scissile phosphate to be the most likely reaction‐competent conformation. Active‐site residue His309 is found to be protonated based on pKa calculations and the higher conformational stability of the Ape1‐DNA substrate complex compared to scenarios with neutral His309. Simulations of the D210N mutant further support the prevalence of protonated His309 and strongly suggest Asp210 as the general base for proton acceptance by a nucleophilic water molecule.
Massive Hospital Admission of Patients with Respiratory Failure Resulting from Smoke Inhalation Injury: The Cromagnon Republic Tragedy

Mass casualties involve such a large numbers of victims, or patients with severe or unique injuries, that regular medical resources cannot completely assist them. This definition evokes what happened in Buenos Aires City after the most deadly fire disaster occurred in a discotheque during an overcrowded rock concert. From 1992 to 1994 Buenos Aires suffered two terrorist attacks, which led to the development of an organized disaster plan and the perception that any prevention is never enough to handle these catastrophes. Different types of disasters, such as fires, terrorist attacks, floods, earthquakes, and accidents involving radiation or infectious or chemical agents, result in very different patterns of injury and medical necessity. Fire disasters also are associated with different patterns of injury, depending on whether they occur indoors or outdoors. Indoor fire disasters result in a higher cumulative death rate than outdoor disasters. Moreover, indoor fire disasters cause a great number of deaths at the scene. However, outdoor disasters result in the admission of patients with more extensive burns. This knowledge assisted us in preparing our disaster medical response according to the anticipated victims’ necessities. Disaster medical response during mass casualties is usually focused on prehospital care issues, such as casualty evacuation, triage, and transport, without specific emphasis on hospital management. Moreover, frequently the prehospital triage at the scene is limited and disorganized, and the priority is to transfer the greatest number of casualties rather than appropriately categorizing the victims’ injuries for more definitive care. Therefore, the number of critical care beds and the availability of adequate equipment and qualified medical personnel are limiting factors in the medical response during these events and are important determinants of the outcome for these severely injured patients. The present study report describes the experience of Argerich General Hospital in the management of a massive admission of patients with severe smoke inhalation toxicity due to a fire disaster during an indoor rock concert in Buenos Aires in December 2004. Its survivors acknowledged this dreadful episode as “The Cromagnon Republic Tragedy. ”
Enhanced Critical Current Density in Bulk MgB2

The object of this investigation is to improve the flux pinning and critical current density <inline-formula> <tex-math notation="LaTeX">$(J_{c})$</tex-math></inline-formula> of bulk MgB<sub>2</sub> materials for daily applications including superconducting permanent magnets. We prepared two sets of bulk MgB<sub>2</sub> materials employing commercial high-purity powders of Mg metal and carbon-coated amorphous B using a single-step solid-state reaction process. The first set of samples was produced by a single-step solid-state reaction at various temperatures between 794 °C and 806 °C in steps of 3 °C in pure argon atmosphere to optimize the sintering temperature. Further, the second set of samples was produced from Mg-rich MgB<sub>2</sub> material adding 1.5 wt% carbon-coated amorphous B powder to it, combined with 4 wt% of silver. X-ray diffraction analysis showed that samples were single-phase MgB<sub>2</sub> with minor trace of impurities. In all samples, sharp superconducting transition temperatures were observed around 38 K, which was decreased around 1 K in MgB<sub>2</sub> material produced with 1.5 wt% of carbon encapsulated boron. The critical current densities in Mg-rich MgB<sub>2</sub> material with 4 wt% of Ag were lower than in silver-free MgB <sub>2</sub> bulks. The sample with 1.5 wt% of carbon-coated B exhibited the highest <inline-formula> <tex-math notation="LaTeX">$J_{c}$</tex-math></inline-formula> of 460 kA/cm<sup>2</sup> at 20 K and self-field. Our results demonstrate a strong correlation between the microstructure achieved and the resulting pinning performance.
Clinical Implications of Non-A-Type NPM1 and FLT3 Mutations in Patients with Normal Karyotype Acute Myeloid Leukemia

Mutations in the nucleophosmin (NPM1) and fms-like tyrosine kinase-3 (FLT3) genes are the most commonly observed mutations in patients with normal-karyotype acute myeloid leukemia (AML-NK). We analyzed the prognostic effects and interactions of these mutations in 201 AML-NK patients. NPM1 and FLT3 mutations were found in 38.3 and 24.9% of AML-NK patients, respectively. NPM1 mutations (NPM1mut), especially in patients without FLT3 mutations (FLT3mut), were associated with a favorable outcome. However, NPM1mut did not affect survival. FLT3mut tended to be associated with a poor survival outcome. FLT3mut showed no prognostic effects in patients with A-type NPM1mut. However, FLT3mut were associated with a significantly worse prognosis in patients with non-A-type NPM1mut. The prognostic interaction between the NPM1 and FLT3 mutations was significant in patients with non-A-type NPM1mut.
Consensus guidelines on the use of bisphosphonate therapy in children and adolescents

Bisphosphonate therapy is the mainstay of pharmacological intervention in young people with skeletal fragility. The evidence of its use in a variety of conditions remains limited despite over three decades of clinical experience. On behalf of the Australasian Paediatric Endocrine Group, this evidence‐based consensus guideline presents recommendations and discusses the graded evidence (using the GRADE system) for these recommendations. Primary bone fragility disorders such as osteogenesis imperfecta are considered separately from osteoporosis secondary to other clinical conditions (such as cerebral palsy, Duchenne muscular dystrophy). The use of bisphosphonates in non‐fragility conditions, such as fibrous dysplasia, avascular necrosis, bone cysts and hypercalcaemia, is also discussed. While these guidelines provide an evidence‐based approach where possible, further research is required in all clinical applications in order to strengthen the recommendations made.
SIGNIFICANCE OF U-WRAP FRP SHEAR STRENGTHENING ON FLEXURAL BEHAVIOR OF RC BEAMS STRENGTHENED USING NEAR SURFACE MOUNTED FRP BARS

The aim of this study is to investigate the significance of U-wrap shear strengthening on the flexural behavior of Near Surface Mounted (NSM) Fiber Reinforced Polymers (FRP) strengthened Reinforced Concrete (RC) beams. It is well-known that the performance of NSM-FRP technique is strongly dependent on bond performance between adhesive-concrete and adhesive-FRP interface. Although a full development length is provided for the NSM FRP bar, rupture of the FRP bar is highly unlikely. This is attributed to the fact that the NSM FRP bar typically observes a stress level lower than 60% of its ultimate capacity at RC beam failure by debonding of NSMFRP from the surrounding adhesive. Here, a typical three-side FRP U-wrap using wet layup was employed to improve the shear strength of the RC beam. A test matrix of 25 beams was tested under static load to failure. Four sets were considered including conventional RC beams, RCbeams with U-wrap only, RC-beams with NSM-FRP strengthening only without U-wrap FRP
Infectious diseases specialty intervention is associated with decreased mortality and lower healthcare costs.

BACKGROUND Previous studies, largely based on chart reviews with small sample sizes, have demonstrated that infectious diseases (ID) specialists positively impact patient outcomes. We investigated how ID specialists impact mortality, utilization, and costs using a large claims dataset. METHODS We used administrative fee-for-service Medicare claims to identify beneficiaries hospitalized from 2008 to 2009 with at least 1 of 11 infections. There were 101 991 stays with and 170 336 stays without ID interventions. Cohorts were propensity score matched for patient demographics, comorbidities, and hospital characteristics. Regression models compared ID versus non-ID intervention and early versus late ID intervention. Risk-adjusted outcomes included hospital and intensive care unit (ICU) length of stay (LOS), mortality, readmissions, hospital charges, and Medicare payments. RESULTS The ID intervention cohort demonstrated significantly lower mortality (odds ratio [OR], 0.87; 95% confidence interval [CI], .83 to .91) and readmissions (OR, 0.96; 95% CI, .93 to .99) than the non-ID intervention cohort. Medicare charges and payments were not significantly different; the ID intervention cohort ICU LOS was 3.7% shorter (95% CI, -5.5% to -1.9%). Patients receiving ID intervention within 2 days of admission had significantly lower 30-day mortality and readmission, hospital and ICU length of stay, and Medicare charges and payments compared with patients receiving later ID interventions. CONCLUSIONS ID interventions are associated with improved patient outcomes. Early ID interventions are also associated with reduced costs for Medicare beneficiaries with select infections.
Legal-System Arbitrage and Parent-Subsidiary Capital Structures

This paper develops a new theory of the capital structure of parent--subsidiary organizations based on legal-system arbitrage: The capital structure of parent--subsidiary organizations is chosen to minimize the agency costs generated by selective renegotiation of claims written on the component legal entities. We show that optimal mixes of parent--subsidiary level financing minimize the default premia associated with the organization's overall financing package by equating the marginal enforceability of debt contracts written at the parent and subsidiary level. The enforceability of creditor claims depends not only on the legal regime but also on the size of the debt claims and the liquidation value of the firm's assets. Small claims written under a weak creditor rights regime may be more enforceable than large claims written under a regime with strong creditor protection. Thus, all optimal mixes involve some borrowing at the subsidiary level even if the subsidiary legal regime features weaker creditor protection than the parent regime. However, the mix between parent and subsidiary financing tilts toward the regime that features stronger creditor protection.
Beyond individual behaviour change: the role of power, knowledge and strategy in tackling climate change

Individual behaviour change is fast becoming a kind of ‘holy grail’ to tackle climate change, in environmental policy, the environmental movement and academic literature. This is contested by those who claim that social structures are the main problem and who advocate collective social action. The objective of the research presented in this paper is to better understand why environmentally concerned citizens choose one of these two types of engagement. Our focus is on the role of experiences of and/or convictions about power in shaping this choice. Within the framework of an explorative qualitative study, we engaged in in-depth interviews with 12 young environmentally concerned citizens. On this basis, five main findings are elaborated. Firstly, powerlessness is shown to be a crucial experience, whatever the respondents’ engagement. Secondly, ‘strategy scepticism’ seems to be a more important obstacle for engagement than ‘climate scepticism’. Thirdly, many respondents express significant resistance towards being ‘conditioned’ by awareness-raising campaigns. Fourthly, a ‘gap’ is observed between respondents’ analysis and their strategy proposals. Finally, we underscore another important gap between concrete and abstract levels in respondents’ discourses. All these findings disclose paradoxical aspects of the role of power in shaping the concerned citizens’ engaged choices.
Slow and fast rod ERG pathways in patients with X-linked complete stationary night blindness carrying mutations in the NYX gene.

PURPOSE To study the slow and fast rod signals of the scotopic 15-Hz flicker ERG in patients carrying mutations in the NYX gene, which has been recently identified as the cause of the complete form of congenital stationary night blindness, CSNB1. METHODS Twenty eyes of 11 patients with CSNB1 who had nondetectable standard ERG rod b-waves were involved in the study. Scotopic ERG response amplitudes and phases to flicker intensities ranging from -3.37 to -0.57 log scotopic trolands. sec (scot td. sec) were measured at a flicker frequency of 15 Hz. ERG signals to flicker intensities between -3.37 and -1.97 and between -1.17 and -0.57 log scot td. sec were considered to represent primarily the slow and fast rod ERG pathway, respectively. Additionally, standard ERGs were performed. Twenty-two normal volunteers served as control subjects. RESULTS For the slow rod ERG pathway, all patients exhibited ERG signals that were indistinguishable from noise. Accordingly, there was no systematic phase behavior for the slow rod signals. For the fast rod ERG pathway, the signals were significantly above noise, but they were significantly reduced in amplitude and advanced in phase. CONCLUSIONS There is evidence that the slow and the fast rod ERG signals can be attributed to the rod bipolar-AII cell pathway and the rod-cone-coupling pathway, respectively. The current study provides evidence to suggest that a defective NYX gene product (nyctalopin) prevents detectable signal transmission through ON rod bipolar cells, but there is a residual transmission through rod-cone gap junctions in CSNB1, possibly through the OFF cone pathway.
Oxy133, a novel osteogenic agent, promotes bone regeneration in an intramembranous bone‐healing model

Current reconstructive techniques for complex craniofacial osseous defects are challenging and are associated with significant morbidity. Oxysterols are naturally occurring cholesterol oxidation products with osteogenic potential. In this study, we investigated the effects of a novel semi‐synthetic oxysterol, Oxy133, on in vitro osteogenesis and an in vivo intramembranous bone‐healing model. Rabbit bone marrow stromal cells (BMSCs) were treated with either Oxy133 or BMP‐2. Alkaline phosphatase (ALP) activity, expression of osteogenic gene markers and in vitro mineralization were all examined. Next, collagen sponges carrying either Oxy133 or BMP‐2 were used to reconstruct critical‐sized cranial defects in mature rabbits and bone regeneration was assessed. To determine the mechanism of action of Oxy133 both in vitro and in vivo, rabbit BMSCs cultures and collagen sponge/Oxy133 implants were treated with the Hedgehog signalling pathway inhibitor, cyclopamine, and similar outcomes were measured. ALP activity in rabbit BMSCs treated with 1 μm Oxy133 was induced and was significantly higher than in control cells. These results were mitigated in cultures treated with cyclopamine. Expression of osteogenic gene markers and mineralization in BMSCs treated with 1 μm Oxy133 was significantly higher than in control groups. Complete bone regeneration was noted in vivo when cranial defects were treated with Oxy133; healing was incomplete, however, when cyclopamine was added. Collectively, these results demonstrate that Oxy133 has the ability to induce osteogenic differentiation in vitro in rabbit BMSCs and to promote robust bone regeneration in vivo in an animal model of intramembranous bone healing. Copyright © 2015 John Wiley & Sons, Ltd.