Miracle-dz/UniFAR-FTUs huggingface dataset:
Influence of Electromagnetic Fields Emitted by GSM-900 Cellular Telephones on the Circadian Patterns of Gonadal, Adrenal and Pituitary Hormones in Men

Abstract Djeridane, Y. , Touitou, Y. and de Seze, R. Influence of Electromagnetic Fields Emitted by GSM-900 Cellular Telephones on the Circadian Patterns of Gonadal, Adrenal and Pituitary Hormones in Men. Radiat. Res. 169, 337–343 (2008). The potential health risks of radiofrequency electromagnetic fields (RF EMFs) emitted by mobile phones are currently of considerable public interest. The present study investigated the effect of exposure to 900 MHz GSM radiofrequency radiation on steroid (cortisol and testosterone) and pituitary (thyroid-stimulating hormone, growth hormone, prolactin and adrenocorticotropin) hormone levels in 20 healthy male volunteers. Each subject was exposed to RF EMFs through the use of a cellular phone for 2 h/day, 5 days/ week, for 4 weeks. Blood samples were collected hourly during the night and every 3 h during the day. Four sampling sessions were performed at 15-day intervals: before the beginning of the exposure period, at the middle and the end of the exposure period, and 15 days later. Parameters evaluated included the maximum serum concentration, the time of this maximum, and the area under the curve for hormone circadian patterns. Each individual's pre-exposure hormone concentration was used as his control. All hormone concentrations remained within normal physiological ranges. The circadian profiles of prolactin, thyroid-stimulating hormone, adrenocorticotropin and testosterone were not disrupted by RF EMFs emitted by mobile phones. For growth hormone and cortisol, there were significant decreases of about 28% and 12%, respectively, in the maximum levels when comparing the 2-week (for growth hormone and cortisol) and 4-week (for growth hormone) exposure periods to the pre-exposure period, but no difference persisted in the postexposure period. Our data show that the 900 MHz EMF exposure, at least under our experimental conditions, does not appear to affect endocrine functions in men.
Antecedents of organizational commitment and the mediating role of job satisfaction

Investigates the relationships between employees’ perceptions of organisational culture and subculture, and job satisfaction and commitment. Questionnaires containing the above measures were distributed to nurses employed in seven large hospitals and a total of 251 responses were obtained. Measures of leadership style and employee demographics were also included in the questionnaire. Regression analysis was used to investigate the extent to which nurses’ job satisfaction and commitment to their wards are predicted by their perceptions of the hospitals’ cultures (or organisational culture), the cultures of their wards (or organisation subculture), the leadership styles of their ward managers, and several demographic characteristics including age, experience, education and job tenure. It was found that ward culture was more predictive of commitment than was hospital culture. Also, statistically controlling for job satisfaction did not substantially reduce the influence on commitment of any of the independent variables included in this study. The results suggest that managers may need to focus more on organizational subcultures in generating greater commitment among employees.
Semi-supervised DNN training in meeting recognition

Training acoustic models for ASR requires large amounts of labelled data which is costly to obtain. Hence it is desirable to make use of unlabelled data. While unsupervised training can give gains for standard HMM training, it is more difficult to make use of unlabelled data for discriminative models. This paper explores semi-supervised training of Deep Neural Networks (DNN) in a meeting recognition task. We first analyse the impact of imperfect transcription on the DNN and the ASR performance. As labelling error is the source of the problem, we investigate two options available to reduce that: selecting data with fewer errors, and changing the dependence on noise by reducing label precision. Both confidence based data selection and label resolution change are explored in the context of two scenarios of matched and unmatched unlabelled data. We introduce improved DNN based confidence score estimators and show their performance on data selection for both scenarios. Confidence score based data selection was found to yield up to 14.6% relative WER reduction, while better balance between label resolution and recognition hypothesis accuracy allowed further WER reductions by 16.6% relative in the mismatched scenario.
People with learning disabilities who have cancer: an ethnographic study.

BACKGROUND Cancer incidence among people with learning disabilities is rising. There have been no published studies of the needs and experiences of people with learning disabilities and cancer, from their own perspective. AIM To provide insight into the experiences and needs of people with learning disabilities who have cancer. DESIGN OF STUDY Prospective qualitative study, using ethnographic methods. SETTING Participants' homes, hospitals, nursing homes, and hospices in London and surrounding areas. METHOD The participants were 13 people with learning disabilities ranging from mild to severe, who had a cancer diagnosis. The main method of data collection was participant observation (over 250 hours). The median length of participation was 7 months. RESULTS Participants' cancer experiences were shaped by their previous experience of life, which included deprivation, loneliness, and a lack of autonomy and power. They depended on others to negotiate contact with the outside world, including the healthcare system. This could lead to delayed cancer diagnosis and a lack of treatment options being offered. Most participants were not helped to understand their illness and its implications. Doctors did not make an assessment of capacity, but relied on carers' opinions. CONCLUSION Urgent action is warranted by findings of late diagnosis, possible discrimination around treatment options, and lack of patient involvement and assessment of capacity in decision making. There are significant gaps in knowledge and training among most health professionals, leading to disengaged services that are unaware of the physical, emotional, and practical needs of people with learning disabilities, and their carers.
Quantitative RestRictions and Residential WateR demand : a spatial analysis of neighboRhood effects

This article investigates the role of spatial pattern in residential outdoor water use and implications for the efficacy of non-price restrictions. Drawing on a spatially explicit dataset, the analysis characterizes latent neighborhood effects in households’ outdoor water use and how these effects vary during water restrictions. Results illustrate that spatial patterns in water use vary across time periods and parcel sizes, and that correlations during water restrictions differ from those during other periods. Water use patterns of this type, largely overlooked by the current literature, have direct implications for the effectiveness of monitoring strategies used to promote compliance with non-
Multiple mechanisms of reflex bronchospasm in guinea pigs.

The mechanisms of histamine- and bradykinin-induced reflex bronchospasm were determined in anesthetized guinea pigs. With intravenous administration, both autacoids evoked dose-dependent increases in tracheal cholinergic tone. Vagotomy or atropine prevented these tracheal reflexes. When delivered as an aerosol, bradykinin readily increased tracheal cholinergic tone, whereas histamine aerosols were much less effective at inducing tracheal reflexes. Also, unlike histamine, bradykinin could evoke profound increases in cholinergic tone without directly or indirectly (e.g., prostanoid dependent) inducing measurable airway smooth muscle contraction resulting in bronchospasm. Neither autacoid required de novo synthesis of prostanoids or nitric oxide to induce reflex tracheal contractions. Combined cyclooxygenase inhibition and tachykinin-receptor antagonism did, however, abolish all effects of bradykinin in the airways, whereas responses to histamine were unaffected by these pretreatments. The data indicate that histamine and bradykinin initiate reflex bronchospasm by differential activation of vagal afferent nerve subtypes. We speculate that selective activation of either airway C fibers or airway rapid adapting receptors can initiate reflex bronchospasm.
Mechanisms of immunity in typhus infections. V. Demonstration of Rickettsia mooseri-specific antibodies in convalescent mouse and human serum cytophilic for mouse peritoneal macrophages

Antibodies in both mouse and human Rickettsia mooseri (Rickettsia typhi) convalescent serum that were cytophilic for mouse macrophages were demonstrated by the rosette technique. Mouse peritoneal macrophages, passively sensitized with early and late serum from mice with a sublethal infection of R. mooseri, were washed and exposed to rickettsiae. Rosettes of rickettsiae were found around macrophages, maintained at 4 degrees C, which had been sensitized with immune serum (direct sensitization of macrophages), but no rosettes were found around macrophages sensitized with serum from normal mice. When the macrophages were maintained at 34 degrees C after addition of the rickettsiae, phagocytosis of rickettsiae occurred, indicating one probable role for cytophilic antibodies in typhus infections. If the rickettsiae were mixed with serum from infected mice, washed, and then added to macrophages (indirect sensitization of macrophages), more rosettes were found around the macrophages than around directly sensitized macrophages. The presence of mouse immunoglobulin G on the macrophage surface was also shown by staining living sensitized macrophages with rabbit fluroescein-conjugated anti-mouse immunoglobulin G.
Quantifying fluctuation in dementia with Lewy bodies, Alzheimer’s disease, and vascular dementia

Background: Case reports and clinical observations suggest that fluctuating cognition (FC) is common in the major dementias, particularly dementia with Lewy bodies (DLB), where it is one of three core clinical diagnostic features. Objectives: To examine the frequency, characteristics, and diagnostic utility of FC in dementia using clinical, attentional, and EEG markers. Method:— A total of 155 subjects (61 with AD, 37 with DLB, 22 with vascular dementia [VaD], 35 elderly controls) received clinical evaluation for FC using a semiquantified measure applied by experienced clinicians and 90-second cognitive choice reaction time (CRT) and vigilance reaction time (VIGRT) trials. Forty subjects also received an evaluation of mean EEG frequency across 90 seconds. Results: Patients with DLB had a greater prevalence and severity of FC than did patients with AD or VaD rated using clinical, attentional, and EEG measures. The 90-second cognitive and EEG trials demonstrated that FC occurs on a second-to-second basis in patients with DLB. Patients with VaD had a higher prevalence of FC than did those with AD, although the profile of FC was different from that expressed by DLB cases. Optimal cutoff values on the clinical scale achieved good discrimination between the dementia groups (sensitivity 81%, specificity 92%, DLB versus AD; sensitivity 81%, specificity 82%, DLB versus VaD; sensitivity 64%, specificity 77%, VaD versus AD). Conclusion: Standardized assessment methods demonstrate that FC is significantly more common and severe in DLB than in other major dementias. The periodicity of FC is different in DLB and VaD cases, with important implications for the underlying causal mechanisms and for differential diagnosis.
Kin discrimination between sympatric Bacillus subtilis isolates

Significance Microorganisms are directly influenced by actions of their neighbors, and cooperative behaviors are favored among relatives. Only a few microbial species are known to discriminate between kin and nonkin, and distribution of this trait within sympatric bacterial populations is still poorly understood. Here we provide evidence of kin discrimination among micrometer-scale soil isolates of Bacillus subtilis, which is reflected in striking boundaries between nonkin sympatric conspecifics during cooperative swarming on agar. Swarming incompatibilities were frequent and correlated with phylogenetic relatedness, as only the most related strains merged swarms. Moreover, mixing of strains during colonization of a plant root suggested possible antagonism between nonkin. The work sheds light on kin discrimination on a model Gram-plus bacterium. Kin discrimination, broadly defined as differential treatment of conspecifics according to their relatedness, could help biological systems direct cooperative behavior toward their relatives. Here we investigated the ability of the soil bacterium Bacillus subtilis to discriminate kin from nonkin in the context of swarming, a cooperative multicellular behavior. We tested a collection of sympatric conspecifics from soil in pairwise combinations and found that despite their history of coexistence, the vast majority formed distinct boundaries when the swarms met. Some swarms did merge, and most interestingly, this behavior was only seen in the most highly related strain pairs. Overall the swarm interaction phenotype strongly correlated with phylogenetic relatedness, indicative of kin discrimination. Using a subset of strains, we examined cocolonization patterns on plant roots. Pairs of kin strains were able to cocolonize roots and formed a mixed-strain biofilm. In contrast, inoculating roots with pairs of nonkin strains resulted in biofilms consisting primarily of one strain, suggestive of an antagonistic interaction among nonkin strains. This study firmly establishes kin discrimination in a bacterial multicellular setting and suggests its potential effect on ecological interactions.
The COP9 Signalosome Is Required for Autophagy, Proteasome-Mediated Proteolysis, and Cardiomyocyte Survival in Adult Mice

Background—The COP9 signalosome (CSN) is an evolutionarily conserved protein complex composed of 8 unique protein subunits (CSN1 through CSN8). We have recently discovered in perinatal mouse hearts that CSN regulates not only proteasome-mediated proteolysis but also macroautophagy. However, the physiological significance of CSN in a post-mitotic organ of adult vertebrates has not been determined. We sought to study the physiological role of CSN8/CSN in adult mouse hearts. Methods and Results—Csn8 was conditionally ablated in the cardiomyocytes of adult mice (CSN8CKO) using a temporally controlled Cre-LoxP system. Loss of CSN8 accumulated the neddylated forms of cullins and noncullin proteins, increased ubiquitinated proteins, and stabilized a surrogate substrate of the proteasome in the heart. Autophagic flux was significantly decreased, whereas autophagosomes were markedly increased in CSN8CKO hearts, indicative of impaired autophagosome removal. Furthermore, we observed increased oxidized proteins, massive necrotic cardiomyocytes, and morphological and functional changes characteristic of dilated cardiomyopathy in CSN8CKO mice. Conclusions—CSN deneddylates substrates more than cullins and is indispensable to cardiomyocyte survival in not only perinatal hearts but also adult hearts. CSN8/CSN regulates both proteasome-mediated proteolysis and the autophagic-lysosomal pathway, critical to the removal of oxidized proteins in the heart.
Relaxivity of gadolinium complexes detected by atomic magnetometry

Laser atomic magnetometry is a portable and low‐cost yet highly sensitive method for low magnetic field detection. In this work, the atomic magnetometer was used in a remote‐detection geometry to measure the relaxivity of aqueous gadolinium‐diethylenetriamine pentaacetic acid Gd(DTPA) at the Earth's magnetic field (40 μT). The measured relaxivity of 9.7 ± 2.0 s−1 mM−1 is consistent with field‐cycling experiments measured at slightly higher magnetic fields, but no cryogens or strong and homogeneous magnetic field were required for this experiment. The field‐independent sensitivity of 80 fT Hz–1/2 allowed an in vitro detection limit of ∼ 10 μM Gd(DTPA) to be measured in aqueous buffer solution. The low detection limit and enhanced relaxivity of Gd‐containing complexes at Earth's field motivate continued development of atomic magnetometry toward medical applications. Magn Reson Med 66:603–606, 2011. © 2011 Wiley‐Liss, Inc.
The Coevolution of Sustainable Strategic Management in the Global Marketplace

Sustainable strategic management emerged from the coevolution of strategic thinking in today’s sustainability challenging business environment. Business ecosystems, designed to create socially and ecologically responsible economic opportunities for their members, have emerged as excellent structures for implementing sustainable strategic management strategies along the whole pyramid of coevolving developed, developing, and undeveloped markets. Both the business ecosystem leaders and niche players in these whole pyramid business ecosystems have critical roles to play in formulating and implementing potentially profitable strategies that help reduce the human footprint and improve the quality of human life. Ecosystem leaders need to be responsible for creating and shepherding their business ecosystems’ visions of a sustainable future, and niche players need to be responsible for providing the ecosystem with an innovation trajectory designed to make those visions a reality.
Role of Gaze Cues in Interpersonal Motor Coordination: Towards Higher Affiliation in Human-Robot Interaction

Background The ability to follow one another’s gaze plays an important role in our social cognition; especially when we synchronously perform tasks together. We investigate how gaze cues can improve performance in a simple coordination task (i.e., the mirror game), whereby two players mirror each other’s hand motions. In this game, each player is either a leader or follower. To study the effect of gaze in a systematic manner, the leader’s role is played by a robotic avatar. We contrast two conditions, in which the avatar provides or not explicit gaze cues that indicate the next location of its hand. Specifically, we investigated (a) whether participants are able to exploit these gaze cues to improve their coordination, (b) how gaze cues affect action prediction and temporal coordination, and (c) whether introducing active gaze behavior for avatars makes them more realistic and human-like (from the user point of view). Methodology/Principal Findings 43 subjects participated in 8 trials of the mirror game. Each subject performed the game in the two conditions (with and without gaze cues). In this within-subject study, the order of the conditions was randomized across participants, and subjective assessment of the avatar’s realism was assessed by administering a post-hoc questionnaire. When gaze cues were provided, a quantitative assessment of synchrony between participants and the avatar revealed a significant improvement in subject reaction-time (RT). This confirms our hypothesis that gaze cues improve the follower’s ability to predict the avatar’s action. An analysis of the pattern of frequency across the two players’ hand movements reveals that the gaze cues improve the overall temporal coordination across the two players. Finally, analysis of the subjective evaluations from the questionnaires reveals that, in the presence of gaze cues, participants found it not only more human-like/realistic, but also easier to interact with the avatar. Conclusion/Significance This work confirms that people can exploit gaze cues to predict another person’s movements and to better coordinate their motions with their partners, even when the partner is a computer-animated avatar. Moreover, this study contributes further evidence that implementing biological features, here task-relevant gaze cues, enable the humanoid robotic avatar to appear more human-like, and thus increase the user’s sense of affiliation.
Detection and characterization of class 1 integrons in Aeromonas spp. isolated from human diarrheic stool in Mexico

We determined the presence of class 1 integrons related to the acquisition of resistance to antimicrobials in Aeromonas spp. isolated from individuals with diarrhea. Species were identified as A. caviae, A. hydrophila, A. veronii and A. media using PCR‐RFLP of the 16S rDNA. Selected isolates were further characterized by ERIC‐PCR. Resistance to chloramphenicol, aztreonam, tetracycline, trimethoprim/sulfamethoxazole, nalidixic acid and streptomycin, among others, was determined using the Kirby‐Bauer method. Integrons were detected by PCR amplification of the 5′ conserved, variable, and 3′ conserved regions. Sequencing of the variable regions revealed class 1 integrons with cassettes encoding resistance to trimethoprim (dfrA12, dfrA15, dfrB4), streptomycin/spectinomycin (aadA2, aadA1), oxacillin (oxa2) and chloramphenicol (catB3, cmlA4). Others had an open reading frame (orfD) or no insert at all. To our knowledge, this is the first description of the occurrence of genes cmlA4 and dfrA15 in Aeromonas class 1 integrons. Not all the integron‐linked cassettes conferred their associated resistances, which suggests the inactivity of some cassettes. Most integrons were chromosomally located. The presence of class 1 integrons similar to those found in a wide variety of bacterial genera from different origins, including environmental and fish‐borne Aeromonas, confirms the stability and horizontal transfer of these genetic elements. (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
On the Relationship between Language Learning Strategies and Personality Types among Iranian EFL Learners

In recent years, language-learning research has been more concerned with factors that may affect the choice of learning strategies among learners. In studies conducted by Cohen (1990), Ehrman and Oxford (1995), MacIntyre and Gardner (1989) and Reid (1987), these factors have been identified as motivation, gender, learning style, previous experience, and personality type. This study attempts to find out the kinds of language learning strategies that Iranian EFL learners mostly utilize. In addition, the language learning strategies preferred by Iranian extrovert/introvert, sensing/intuitive, thinking/feeling, and judging/perceiving language learners are also considered. The sample of the study included 137 Iranian EFL learners at MA level, studying at different branches of the Islamic Azad University and University of Teacher Education, who were randomly selected for the purpose of this study. The instruments utilized in this study were (a) Myers-Briggs Type Indicator (MBTI) to identify the kind of personality type language learners have, and (b) Strategy Inventory for Language Learning (SILL) to assess the learners' strategy-use-frequency in language learning. The results of the study showed that learners with extrovert and introvert personality types did not show any significant difference regarding the use of language learning strategies. Both sensing and intuitive learners preferred to use affective strategies. The findings also indicated that thinking, as well as feeling learners, used memory and social strategies. Perceiving learners used two categories of strategies, cognitive and compensation, whereas judging learners employed only the compensation strategy.