Miracle-dz/UniFAR-FTUs huggingface dataset:
Reproducibility of grading systems for endometrial endometrioid carcinoma and their relation with pathologic prognostic parameters

The FIGO grading for endometrial endometrioid carcinomas is widely accepted. In 2000, a novel binary architectural grading system was suggested that divided endometrioid carcinomas into low- and high-grade tumors. We aimed to evaluate the interobserver reproducibility of the FIGO, the architectural binary, and nuclear grading systems and the correlation between these grading systems and pathologic prognostic factors for endometrial endometrioid carcinoma. Eighty-eight endometrial endometrioid carcinomas from hysterectomy specimens were reevaluated by two pathologists independently. Kappa values for the FIGO, the binary, and the nuclear grading systems were 0.65, 0.67, and 0.09, respectively. The reproducibility of the FIGO and the binary grading systems was similar and substantial. FIGO grade 1 (60.2%) patients were comparable to binary low-grade (63.6%) patients. Most of the FIGO grade 3 (83%) patients were binary high grade. FIGO grade 2 patients were distributed between binary low and high grades. The FIGO grade 1 and 2 cases judged to be of binary high grade had deep myometrial invasion, and more cases had vascular invasion in comparison with FIGO grade 1 and 2 cases judged to be of binary low grade. In uni-and multivariate analyses, both grading systems, depth of myometrial invasion, vascular invasion, cervical involvement, and stage had no effect on overall survival. But binary high grade and vascular involvement are adverse prognostic factors on recurrence-free survival. Binary high-grade patients can be assigned as high-risk patients.
Hemolytic Uremic Syndrome: Late Renal Injury and Changing Incidence—A Single Centre Experience in Canada

Aims. To assess trends in the incidence of pediatric diarrhea-associated hemolytic uremic syndrome (D+ HUS) and document long-term renal sequelae. Methods. We conducted a retrospective cohort study of children with D+ HUS admitted to a tertiary care pediatric hospital in Montreal, Canada, from 1976 to 2010. In 2010, we recontacted patients admitted before 2000. Results. Of 337 cases, median age at presentation was 3.01 years (range 0.4–14). Yearly incidence peaked in 1988 and 1994-95, returning to near-1977 levels since 2003. Twelve patients (3.6%) died and 19 (5.6%) experienced long-term renal failure. Almost half (47%) The patients required dialysis. Need for dialysis was the best predictor of renal sequelae, accounting for 100% of severe complications. Of children followed ≥1 year (n = 199, mean follow-up 8.20 ± 6.78 years), 19 had severe and 18 mild-to-moderate kidney injury, a total sequelae rate, of 18.6%. Ten years or more after-HUS (n = 85, mean follow-up 15.4 ± 5.32 years), 8 (9.4%) patients demonstrated serious complications and 22 (25.9%) mild-to-moderate, including 14 (16%) microalbuminuria: total sequelae, 35.3%. Conclusions. Patients with D+ HUS should be monitored at least 5 years, including microalbuminuria testing, especially if dialysis was required. The cause of the declining incidence of D+HUS is elusive. However, conceivably, improved public health education may have played an important role in the prevention of food-borne disease.
Complete genome characterization and phylogenetic analysis of WU polyomavirus in Thai pediatric patients with respiratory tract infections in 2013.

BACKGROUND The WU polyomavirus (WUPyV) is a small DNA virus (family Polyomaviridae) that contains a circular double-stranded DNA genome, approximately 5 kb in length. WUPyV was first discovered in the respiratory tract of children with acute respiratory symptoms. OBJECTIVE This study focuses on the complete genome characterization and phylogenetic analysis of WUPyV obtained from Thai patients with respiratory diseases in 2013. MATERIAL AND METHOD DNA was extracted from nasopharyngeal (NP) suction specimens (n = 614) from patients with respiratory tract infections. WUPyV was detected by using semi-nested PCR and then characterized by whole genome sequencing. The nucleotides and deduced amino acid sequences were analyzed by multiple sequences alignment and phylogenetic tree. RESULTS Analysis revealed that 0.16% (1/614) of the sample was positive for WUPyV. Phylogenetic trees demonstrated that WUPyV(isolate CU_Chonburi 3) was closely related to previously described WUPyV. Moreover, whole genome sequences alignment of WUPyV showed several nucleotide variations within non-coding regions and amino acid changes in VP1 (position S347T); VP2 (positions L40V, G120R, Y121I, P123R, G127S, L137F, Q287R, and A327V); LTAg (positions Q357P, V369E, E377K, D378V, A381T, R382E, R383G, and D389G); and, STAg (positions R139S, K141E, R148K, and W153C). CONCLUSION Nucleotide variations within non-coding regions and critical amino acid substitutions in viral proteins may affect the rate of viral replication and viral adaptation; factors that may be linked to the susceptibility and severity of viral infection. Data obtained from this study may be useful in better understanding the genetic characterization and mutation patterns of WUPyV.
Why the Public Schools will Continue to Neglect the Gifted

Their major needs are for fast paced, high level, conceptually oriented learning activities, in large, challenging chunks taught in a dynamic, interactive style by knowledgeable and energetic teachers. There is much concern about the socialemotional adjustment and personal problems of the gifted and talented in spite of research assurance which says that they have no more social-emotional problems than children of average ability (Janos and Robinson, 1985) unless thay are very highly gifted. In those relatively few cases of personal-social problems, they are most likely traceable to the failure of school and family to let them express their giftedness and talent. Many sch%ols provide only innocuous enrichment and socialemotional development activities. Until they reach junior high or high school, gifted and talented youth often have no opportunities for high-powered NEGLECT
Carbonyl reductase as a significant predictor of survival and lymph node metastasis in epithelial ovarian cancer

We have recently reported a novel function for carbonyl reductase (CR), namely, its ability to modulate the metastatic potential of malignant mouse cells. Because there are currently no data addressing a similar function for CR in human cancers, the aim of this study was to assess a correlation between survival and metastasis, and CR level in epithelial ovarian cancer. Using anti-CR antibody, immunohistochemical staining was performed on 73 epithelial ovarian cancers, 13 borderline malignant tumours, and 25 benign ovarian tumours for a total of 111 specimens. The combined rate for strongly and weakly positive reactions for CR was 32.0% for benign tumours, 38.5% for borderline malignant tumours, and 61.6% for ovarian cancers. The CR-positive rate was 35.7% (weakly positive alone) for ovarian cancers with retroperitoneal lymph node (RLN) metastasis and 67.8% for those without RLN metastasis (P< 0.05). The 5-year survival rate was 62.7% for the patients with CR-negative cancer and 86.1% for those with CR-positive cancer (P< 0.05). The present results indicate that decreased CR expression in epithelial ovarian cancer is associated with RLN metastasis and poor survival. © 2001 Cancer Research Campaign http://www.bjcancer. com
Does Social Capital Have an Economic Payoff? A Cross-Country Investigation

This paper presents evidence that "social capital" matters for measurable economic performance, using indicators of trust and civic norms from the World Values Surveys for a sample of 29 market economies. Memberships in formal groups—Putnam's measure of social capital—is not associated with trust or with improved economic performance. We find trust and civic norms are stronger in nations with higher and more equal incomes, with institutions that restrain predatory actions of chief executives, and with better-educated and ethnically homogeneous populations.
Left-dislocation in Italian conversation

1 All the examples of left -di sloca tions a nd a ny st retch of Italia n co nve rsatio n in thi s chap ter are taken from tra nscripts of spo nta neous co nversa tion. Ti tle . page of the tra nscr ipt. a nd. sometimes, contextual in fo rma tio n are presented wi thi n pa ren theses. next lo the number o f the example. Examples with no litle are made up. The co nven tio ns used in transcri bing the audiotapes a re those of conversa t ion a nalys is. We give here some of the co nvent ions and refer the reader to the Appendix in Sacks, Schegloff, a nd Jefferson ( 1974) o r to Schenkein ( 1978: xi xvi) fo r a more detai led lis t. The doub le solidus(//) ind ica tes the poin t a t which the speake r's
Effects of Delay in Multi-Agent Consensus and Oscillator Synchronization

The coordinated motion of multi-agent systems and oscillator synchronization are two important examples of networked control systems. In this technical note, we consider what effect multiple, non-commensurate (heterogeneous) communication delays can have on the consensus properties of large-scale multi-agent systems endowed with nonlinear dynamics. We show that the structure of the delayed dynamics allows functionality to be retained for arbitrary communication delays, even for switching topologies under certain connectivity conditions. The results are extended to the related problem of oscillator synchronization.
SWEL: Hardware cache coherence protocols to map shared data onto shared caches

Snooping and directory-based coherence protocols have become the de facto standard in chip multi-processors, but neither design is without drawbacks. Snooping protocols are not scalable, while directory protocols incur directory storage overhead, frequent indirections, and are more prone to design bugs. In this paper, we propose a novel coherence protocol that greatly reduces the number of coherence operations and falls back on a simple broadcast-based snooping protocol when infrequent coherence is required. This new protocol is based on the premise that most blocks are either private to a core or read-only, and hence, do not require coherence. This will be especially true for future large-scale multi-core machines that will be used to execute message-passing workloads in the HPC domain, or multiple virtual machines for servers. In such systems, it is expected that a very small fraction of blocks will be both shared and frequently written, hence the need to optimize coherence protocols for a new common case. In our new protocol, dubbed SWEL (protocol states are Shared, Written, Exclusivity Level), the L1 cache attempts to store only private or read-only blocks, while shared and written blocks must reside at the shared L2 level. These determinations are made at runtime without software assistance. While accesses to blocks banished from the L1 become more expensive, SWEL can improve throughput because directory indirection is removed for many common write-sharing patterns. Compared to a MESI based directory implementation, we see up to 15% increased performance, a maximum degradation of 2%, and an average performance increase of 2.5% using SWEL and its derivatives. Other advantages of this strategy are reduced protocol complexity (achieved by reducing transient states) and significantly less storage overhead than traditional directory protocols.
Is early antiviral therapy for recurrent hepatitis C after liver transplantation superior to later treatment? The answer is no

Liver disease due to hepatitis C virus (HCV) is the main cause of cirrhosis and hepatocellular carcinoma and is the leading indication for liver transplantation (LT) in Western countries. Unfortunately, reinfection with HCV after LT is universal in patients who are HCV RNA– positive according to polymerase chain reaction at the time of LT, and the course of HCV-induced disease in liver allografts is more rapid than the course of HCVinduced disease in immunologically competent patients. After LT for HCV-related disease, the incidence of chronic infection with HCV is 75% to 90%, and 5% to 30% of patients develop cirrhosis within 5 years. Because of the impact of recurrent HCV infection on graft and patient survival, several treatment strategies for preventing or more effectively treating HCV infection have been evaluated: antiviral treatment before LT, prophylactic therapy, preemptive therapy initiated soon after LT, and therapy for established chronic hepatitis C after LT. Prophylactic therapy is typically started during the anhepatic phase to prevent the reinfection of graft with HCV. In this context, the administration of hepatitis C immune globulin has been disappointing; this approach has been associated with only transient decreases in hepatic HCV RNA and serum aminotransferase levels. Preemptive antiviral therapy should be initiated early after LT, preferably during the first month when the viral load tends to be at its lowest level and hepatic fibrosis is usually absent. In patients with chronic hepatitis C unrelated to LT, a low pretreatment viral load, a mild stage of hepatic fibrosis, and low hepatitis activity are predictors of a high rate of viral clearance. These findings provide a rationale for preemptive therapy. However, such patients differ from those with recurrent HCV infection after LT. Patients with HCV-induced disease who have undergone LT are chronic carriers of HCV, and their response to antiviral therapy may be adversely affected by immunosuppressive therapy. Potential benefits of preemptive therapy include the attenuation of histological indices of disease activity and the retardation of fibrosis progression. The main drawbacks of this therapy are its low applicability and the appreciable risks of poor hematological tolerance, rejection, and sepsis. In a study by Shergill et al., patients who were ineligible for antiviral therapy had significantly higher Model for End-Stage Liver Disease scores before LT. The high prevalence of renal dysfunction and anemia in patients infected with HCV post-LT makes the administration of ribavirin (RBV) difficult in this population. In published studies of preemptive antiviral therapy, sustained virological response (SVR) rates have varied from 8% to 39% (median 1⁄4 16%): 5% to 33% for patients with genotype 1 (G1) and 14% to 100% for patients with genotype 2
Factors mediating the sex difference observed In targeting tasks

ii ACKNOWLEDGEMENTS. iv TABLE OF CONTENTS. v LIST OF TABLES.vii LIST OF FIGURES.vii LIST OF ABBREVIATIONS. ix 1. GENERAL INTRODUCTION . 1 Theory 1: Sex Differences in the Cerebral Organization of the Praxic System . 5 Theory 2: Sex Hormones and Targeting Accuracy. 10 Integration of the Two Theories . 15 Current studies. 16 2. STUDY 1: MEN ARE MORE ACCURATE THAN WOMEN AT AIMING AT TARGETS IN BOTH NEAR SPACE AND EXTRAPERSONAL SPACE . 17 Summary . 18 Introduction . 19 Methods. 21 Results . 23 Discussion . 27 References . 30 Table 1. 32 Table 2. 33 3. RATIONALE FOR STUDY 2 . 34 4. STUDY 2: PROXEMIC AND MOTORIC TASK CHARACTERISTICS INTERACT TO NEGATE THE MALE ADVANTAGE ON TARGETING ACCURACY . 36 Abstract . 37 Introduction . 38. 37 Introduction . 38
The Hidden Adult: Defining Children's Literature

What exactly is a children's book? How is children's literature defined as a genre? A leading scholar presents close readings of six classic stories to answer these questions and offer a clear definition of children's writing as a distinct literary form. Perry Nodelman begins by considering the plots, themes, and structures of six works: "The Purple Jar," Alice in Wonderland, Dr. Doolittle, Henry Huggins, The Snowy Day, and Plain City-all written for young people of varying ages in different times and places-to identify shared characteristics. He points out markers in each work that allow the adult reader to understand it as a children's story, shedding light on ingrained adult assumptions and revealing the ways in which adult knowledge and experience remain hidden in apparently simple and innocent texts. Nodelman then engages a wide range of views of children's literature from authors, literary critics, cultural theorists, and specialists in education and information sciences. Through this informed dialogue, Nodelman develops a comprehensive theory of children's literature, exploring its commonalities and shared themes. The Hidden Adult is a focused and sophisticated analysis of children's literature and a major contribution to the theory and criticism of the genre.
EFL Speaking Inability: Its Causes and Remedies

Abstract The objective of this study is to determine the influential factors contributing to the College students’ English speaking inability. Speaking inability is roughly defined as the inability to speak the target language accurately and fluently. Data for this research were collected through a survey of openended questions and two structured interviews. The conclusions tend to support the role of attitudinal factors in foreign language learning. Another conclusion is that the more the student remains engaged in speaking the greater the opportunity to develop his skill. The recommendations include helping and stimulating both the teacher and the learner to develop a positive attitude towards speaking, to obligatorily speak the target language in and out of the class, to use a variety of techniques to promote the speaking ability, and to lay greater emphasis on communication courses rather than literature courses in the curriculum of the target language.
Involved Fathering and Men's Adult Development: Provisional Balances

Rob Palkowitz. (2002). Involved Fathering and Men's Adult Development: Provisional Balances. Mahwah, NJ: Lawrence Erlbaum Associates. 308 pp. Paperback ISBN: 0-8058-3565-2, $69.95. Involved Fathering and Men's Adult Development: Provisional Balances explores whether men who engage in active parenting develop and mature differently from men who do not. Palkowitz interviewed 40 fathers from various cultures and stages of fathering. He surveyed them on topics related to the domains of self, social, and work. He suggests that there is little empirical research examining the relationship between parental maturity and father involvement from a life-course perspective. His goal was to identify some of the precursors of this maturational process. Throughout the book, Palkowitz highlights the issue of balance. For most of the men, the positive aspects of parenting outweigh any negatives, but most mention a constant struggle to balance their multiple responsibilities. The first section of the book examines previous research and theoretical perspectives significant to fathering and its effect on men's adult development. Palkowitz suggests that empirical support is lacking and that relevant theories of men's adult development do not present an integrated understanding. Palkowitz describes five major themes that emerge from the fathers' responses in this study. The most often expressed themes are that fatherhood activates a "settling down" process for men, motivates them to become more giving, entails major responsibilities, requires caring for the next generation, and initiates major life changes. The second section of the book explores how fathering influences the definition and view of one's self in the areas of emotions, faith, and health. Palkowitz reports that fathers experience more positive emotions than negative, that they are more sensitive to their own and others' emotions, and that they are better able to control their emotions as a result of their experiences as fathers. In terms of faith issues, many of the fathers in this study seem to emphasize serving as moral and spiritual guides rather than merely promoting organized religion. Finally, in regards to physical health, fathers report that they recognize the importance of maintaining healthy lifestyles as models for their children, but many had a difficult time balancing family time and resources with their own fitness needs. The third section of the book examines how fatherhood intersects with the social networks of the men, particularly how this status impacts intimate relationships and relationships with other family members, friends, and the community. There was unanimous agreement among the participants that fatherhood has changed their relationships. They reported that parenting creates stress, more daily hassles, and less time for their partners, including less sexual intimacy. …
OCD symptoms in a sample of Turkish patients: a phenomenological picture

This study aimed to investigate the clinical features of obsessive–compulsive disorder (OCD) and the possible association between obsessive–compulsive symptoms and culture‐related characteristics in a sample of Turkish patients with OCD. We studied 141 patients with OCD (according to DSM‐IV criteria) consecutively admitted to our outpatient clinic during the period from February 1998 to December 2003. We used the Turkish version of the Structured Clinical Interview for DSM‐IV (SCID) to interview all patients, and the Yale–Brown Obsessive–Compulsive Scale (Y‐BOCS) to assess obsessive–compulsive symptoms and severity. The onset of OCD symptoms was earlier in males. Major depression was the most common comorbid disorder (30.5%). The most commonly occurring obsessions were contamination (56.7%), aggression (48.9%), and somatic (24.1%), followed by religious (19.9%), symmetry (18.4%), and sexual imagery (15.6%). Symmetry and sexual obsessions, and checking compulsions and rituals, tended to be more common in male patients. Dirt and contamination obsessions and washing compulsions were slightly more common in females. The vast majority of patients with religious obsessions (83%) and half of the patients with sexual obsessions had compulsions that included religious practices. Also, patients with sexual and religious obsessions had delayed seeking professional help. Depression and Anxiety 23:145–152, 2006. © 2006 Wiley‐Liss, Inc.
The Security Architecture of the Chromium Browser

Most current web browsers employ a monolithic architecture that combines “the user” and “the web” into a single protection domain. An attacker who exploits an arbitrary code execution vulnerability in such a browser can steal sensitive files or install malware. In this paper, we present the security architecture of Chromium, the open-source browser upon which Google Chrome is built. Chromium has two modules in separate protection domains: a browser kernel, which interacts with the operating system, and a rendering engine, which runs with restricted privileges in a sandbox. This architecture helps mitigate high-severity attacks without sacrificing compatibility with existing web sites. We define a threat model for browser exploits and evaluate how the architecture would have mitigated past vulnerabilities.