Miracle-dz/UniFAR-FTUs huggingface dataset:
MECHANISMS UNDERLYING NEBIVOLOL‐INDUCED ENDOTHELIAL NITRIC OXIDE SYNTHASE ACTIVATION IN HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS

1 Nebivolol (NEB) has been shown to be a selective blocker of β1‐adrenoceptors with additional vasodilating properties that are mediated, at least in part, by an endothelial‐dependent liberation of nitric oxide (NO). In the present study, we investigated the underlying mechanisms of NEB‐induced vasodilation. 2 Immunohistochemical staining of endothelial nitric oxide synthase (eNOS) was performed in the absence and presence of NEB in human umbilical vein endothelial cells (HUVEC). In addition, we measured the release of nitric oxide (NO) using diaminofluorescein. Metoprolol (MET) was used for comparison. 3 Nebivolol, but not MET (each at 10 µmol/L), caused a time‐dependent increase in NO release from HUVEC, as demonstrated by an increase in DAF fluorescence at 0 versus 10 min (+234 ± 7 and 55 ± 22% basal, respectively). Blockade of β3‐adrenoceptors by SR 59230A (1 µmol/L) partially reduced the NEB‐induced increase in DAF fluorescence. Complete inhibition of NEB‐induced NO liberation was achieved by the simultaneous blockade of β3‐adrenoceptors and oestrogen receptors (with 1 µmol/L ICI 182,780). 4 Application of NEB significantly increased eNOS translocation and serine 1177 phosphorylation of eNOS. However, NEB did not alter eNOS‐phosphorylation at threonine 495 and at serine 114. 5 In conclusion, the endothelium‐dependent NO liberation induced by NEB is due to stimulation of β3‐adrenoceptors and oestrogen receptors and coincides with eNOS translocation and a phosphorylation at eNOS‐serine 1177. These characteristics of NEB may be beneficial not only when treating patients suffering from cardiovascular disease, but may also prevent further deterioration of endothelial dysfunction.
Isoforms of human B7-H3 co-signalling molecule for T cell activation as potential immunoregulatory agents

B7 family molecules, which are expressed on antigen-presenting cells and display extracellular regions containing immunoglobulin (Ig) variable (V)- and constant (C)-like domains, are known to modulate T cell receptor (TCR)-mediated T cell activation by providing co-signals that are either stimulatory or inhibitory. One of the most recently identified members of this family is B7-H3 (B7 homologue 3). Here, evidence is presented that human B7-H3 exists as two isoforms: B7-H3 VC, which contains one IgV- and IgC-like domain, and B7-H3 VCVC, which contains two such domains. The latter represents the predominant B7-H3 molecule detectable in various human tissues. Both B7-H3 isoforms are shown to decrease the proliferation and cytokine production induced by TCR activation of human T cells in vitro. It is therefore claimed that B7-H3 molecules may provide tools to modulate immune responses for therapeutic purpose.
Effect of proactive personality and decision-making self-efficacy on career adaptability among Chinese graduates

We studied the effect of proactive personality and career decision-making self-efficacy on career adaptability under employment pressure among 810 Chinese graduate students. Participants completed the Proactive Personality Scale, the Career Adapt-Abilities Scale– International Form 2.0, the Career Decision-Making Self-Efficacy Scale, and the Employment Pressure Scale. The results showed: (a) proactive personality affected career adaptability, (b) career decision-making self-efficacy played a mediating role in that relationship, (c) employment pressure moderated the mediating effect on the relationship in (a), and (d) students with a highly proactive personality were more inclined to be influenced by the negative effects of employment pressure than were those with a less proactive personality when forming career decision-making self-efficacy.
Growth-Promoting Relationships between Youth and Adults: A Focus Group Study

The purpose of this exploratory study was to listen to young people's descriptions of their experiences in and understandings of their relationships with the important adults in their lives using relational–cultural theory as the guiding framework. The authors conducted 7 focus groups with ethnically and socioeconomically diverse children and adolescents ages 7 to 18 years (N = 91) who were participants in a range of community groups. A thematic analysis of the focus group transcripts highlighted the high value these youth placed on respect, mutuality, and authenticity in their relationships with adults. These youth also poignantly described their desire for strong relationships with adults and the barriers that unfortunately and too often seemed to get in the way.
Electroencephalography in eating disorders

Clinical applications of electroencephalography (EEG) are used with different objectives, EEG being a noninvasive and painless procedure. In respect of eating disorders, in the 1950s a new line of study about the neurological bases of anorexia nervosa was started and has since been developed. The purpose of this review is to update the existing literature data on the main findings in respect of EEG in eating disorders by means of a search conducted in PubMed. Despite the fact that weight gain tends to normalize some brain dysfunctions assessed by means of EEG, the specific effect of gaining weight remains controversial. Different studies have reported that cortical dysfunctions can be found in patients with anorexia nervosa even after weight gain, whereas others have reported a normalization of EEG in respect of the initial reduced alpha/ increased beta power in those patients with refeeding. Findings of studies that have analyzed the possible relationship between eating disorders and depression, based on sleep EEG disturbances, do not support the idea of eating disorders as a variant of depression or affective disorders. Some EEG findings are very consistent with previous neuroimaging results on patients with anorexia nervosa, reporting neural disturbances in response to stimuli that are relevant to the pathology (eg, stimuli like food exposure, different emotional situations, or body images).
Multi-QTL Mapping for Quantitative Traits Using Epistatic Distorted Markers

The interaction between segregation distortion loci (SDL) has been often observed in all kinds of mapping populations. However, little has been known about the effect of epistatic SDL on quantitative trait locus (QTL) mapping. Here we proposed a multi-QTL mapping approach using epistatic distorted markers. Using the corrected linkage groups, epistatic SDL was identified. Then, these SDL parameters were used to correct the conditional probabilities of QTL genotypes, and these corrections were further incorporated into the new QTL mapping approach. Finally, a set of simulated datasets and a real data in 304 mouse F2 individuals were used to validate the new method. As compared with the old method, the new one corrects genetic distance between distorted markers, and considers epistasis between two linked SDL. As a result, the power in the detection of QTL is higher for the new method than for the old one, and significant differences for estimates of QTL parameters between the two methods were observed, except for QTL position. Among two QTL for mouse weight, one significant difference for QTL additive effect between the above two methods was observed, because epistatic SDL between markers C66 and T93 exists (P = 2.94e-4).
A universal analytic charge injection model

In this paper we present an analytical model for charge injection in MOS switches that is valid for all regions of operation. The model is general and can be applied for different load conditions. We analyze and develop two separate charge injection models for the different operating conditions. A simple continuous model that is valid for all conditions is then stitched together using appropriate functions. Simulation results from this model agree well with previously published measurement results. The model is used to predict charge injection error and nonlinearity.
The Remarkable Logic of Autism: Developing and Describing an Embedded Curriculum Based in Semiotic Phenomenology

Autism spectrum disorder (ASD) is a wildly heterogeneous lived experience of stressed embodiment. Many children, youths and adults with ASD are unable to access meaningful, relevant physical activity programmes because of the complexities associated with their behavioural, emotional and communicative idiosyncrasies. This paper describes an approach to designing, implementing and evaluating a movement-education-based embedded curriculum which was developed using semiotic phenomenology as a theoretical framework for observations, description and analysis of lived experiences of ASD.
Low-rank matrices recovery via entropy function

The low-rank matrix recovery problem consists of reconstructing an unknown low-rank matrix from a few linear measurements, possibly corrupted by noise. One of the most popular method in low-rank matrix recovery is based on nuclear-norm minimization, which seeks to simultaneously estimate the most significant singular values of the target low-rank matrix by adding a penalizing term on its nuclear norm. In this paper, we introduce a new method that requires substantially fewer measurements needed for exact matrix recovery compared to nuclear norm minimization. The proposed optimization program utilizes a sparsity promoting regularization in the form of the entropy function of the singular values. Numerical experiments on synthetic and real data demonstrates that the proposed method outperforms stage-of-the-art nuclear norm minimization algorithms.
Subsets of Human Origin Recognition Complex (ORC) Subunits Are Expressed in Non-proliferating Cells and Associate with Non-ORC Proteins*

The origin recognition complex (ORC) in yeast is a complex of six tightly associated subunits essential for the initiation of DNA replication. Human ORC subunits are nuclear in proliferating cells and in proliferative tissues like the testis, consistent with a role of human ORC in DNA replication. Orc2, Orc3, and Orc5 also are detected in non-proliferating cells like cardiac myocytes, adrenal cortical cells, and neurons, suggesting an additional role of these proteins in non-proliferating cells. Although Orc2–5 co-immunoprecipitate with each other under mild extraction conditions, a holo complex of the subunits is difficult to detect. When extracted under more stringent extraction conditions, several of the subunits co-immunoprecipitate with stoichiometric amounts of other unidentified proteins but not with any of the known ORC subunits. The variation in abundance of individual ORC subunits (relative to each other) in several tissues, expression of some subunits in non-proliferating tissues, and the absence of a stoichiometric complex of all the subunits in cell extracts indicate that subunits of human ORC in somatic cells might have activities independent of their role as a six subunit complex involved in replication initiation. Finally, all ORC subunits remain consistently nuclear, and Orc2 is consistently phosphorylated through all stages of the cell cycle, whereas Orc1 is selectively phosphorylated in mitosis.
Silence is Gold: Strategic Interference Mitigation Using Tokens in Heterogeneous Small Cell Networks

Electronic tokens have been successfully used as incentive mechanisms to stimulate self-interested network nodes to relay other nodes' traffic. In other words, tokens are paid to buy transmission (relaying) services. In this work, we propose a novel distributed token exchange framework, which can be used in heterogeneous small cell networks to successfully mitigate interference among the self-interested users. Contrary to the traditional role of buying transmission, tokens are exchanged between users to buy silence. Heterogeneity poses unique challenges for interference mitigation, which are difficult to handle with previous solutions but can be effectively tackled with the proposed token design. This paper focuses on the rigorous design of the optimal token scheme that minimizes the system outage probability. We first analyze the optimal strategies of individual users, which only consider their own utility maximization and do not care about the system-wise performance. We prove that under some mild conditions the optimal strategy has a simple threshold structure. We then analytically derive the optimal token supply that minimizes the network outage probability. Analysis shows that even if each user adopts the optimal strategy that only maximizes its own utility, a careful token system design can lead to a significant overall network performance improvement. Simulation results show that not only does the proposed token system design greatly improve the network outage probability, it also improves the overall network QoS, particularly when the deployment density is high.
The many faces of study abroad: an update on the research on L2 gains emerged during a study abroad experience

This article offers a critical review of the existing literature on gains in a second language (L2) as a result of a study abroad (SA) experience. The aim of this article is (a) to provide an updated overview of the empirical evidence of L2 gains emerging during an SA experience in order to know what the current situation is, and (b) to identify gaps in the research on SA and evaluate where further research is needed in this area. Issues related to the SA participants' age, background, initial L2 proficiency level, length of stay (LoS) in the L2 country, duration of the effects of these SA experiences, and cognitive skills have been identified as crucial factors to be taken into account when carrying out research on SA as well as when drawing conclusions from the current empirical evidence.
Financial Management and Job Social Skills Training Components in a Summer Business Institute

Ninety-two adolescents, predominantly ethnic minority high school students, participated in a structured Summer Business Institute (SBI). Participating youth were randomly assigned to receive either job social skills or financial management skills training components. Students who additionally received the job social skills training component were more likely to recommend their employment agency to others than were youth who received the financial management component, rated their overall on-the-job work experience more favorably, and demonstrated higher scores in areas that were relevant to the skills that were taught in the job social skills workshops. The financial management component also appeared to be relatively effective, as youth who received this intervention improved their knowledge of financial management issues more than youth who received job social skills, and rated their workshops as more helpful in financial management, as well as insurance management. Future directions are discussed in light of these results.
Gender and Attitudes Toward Quotas for Women Candidates in Canada

This paper examines attitudes toward quotas to improve access to elected office using data from a survey of 2,947 Canadians. The analysis is based on a parallel set of questions about the underrepresentation of women and the underrepresentation of racial minorities that were asked of independent subsamples. Women prove to be more concerned than men about the lack of access to elected office of women and members of racial minorities alike, more likely to believe that increased representation will result in better government, and more supportive of quotas to enhance access. This is found to reflect differences between women and men in their concern for the needs and rights of minorities, awareness of discrimination, and orientations toward the political system. The paper ends with a discussion of the implications of the results for building support for quotas.
Response latencies of pleasure and displeasure ratings: Further evidence for mixed feelings

All studies that examined the co-occurrence of pleasure and displeasure revealed at least some reports of mixed feelings (i.e., reports of concurrent pleasure and displeasure). Some researchers attribute these reports to measurement error, whereas others regard them as valid. This article examined response latencies of affect ratings to test the validity of reported mixed feelings. First, I demonstrate that respondents need more time to indicate the presence of an affect than the absence of an affect on unipolar response formats. Then, I demonstrate that mixed feelings are reported even when response latencies show a unipolar pattern for displeasure ratings, while the results for pleasure ratings were more mixed, but additional evidence suggests that they also are valid reflections of pleasure. In addition, I demonstrate that pleasure and displeasure ratings are independent of item-order and item-spacing. These results provide further support for the validity of reported mixed feelings and two-dimensional representations of pleasure and displeasure.
Reed–Muller Codes for Random Erasures and Errors

This paper studies the parameters for which binary Reed-Muller (RM) codes can be decoded successfully on the binary erasure channel and binary symmetry channel, and, in particular, when can they achieve capacity for these two classical channels. Necessarily, this paper also studies the properties of evaluations of multivariate GF(2) polynomials on the random sets of inputs. For erasures, we prove that RM codes achieve capacity both for very high rate and very low rate regimes. For errors, we prove that RM codes achieve capacity for very low rate regimes, and for very high rates, we show that they can uniquely decode at about the square root of the number of errors at capacity. The proofs of these four results are based on different techniques, which we find interesting in their own right. In particular, we study the following questions about E(m, r), the matrix whose rows are the truth tables of all the monomials of degree ≤ r in m variables. What is the most (resp. least) number of random columns in E(m, r) that define a submatrix having full column rank (resp. full row rank) with high probability? We obtain tight bounds for very small (resp. very large) degrees r, which we use to show that RM codes achieve capacity for erasures in these regimes. Our decoding from random errors follows from the following novel reduction. For every linear code C of sufficiently high rate, we construct a new code C' obtained by tensorizing C, such that for every subset S of coordinates, if C can recover from erasures in S, then C' can recover from errors in S. Specializing this to the RM codes and using our results for erasures imply our result on the unique decoding of the RM codes at high rate. Finally, two of our capacity achieving results require tight bounds on the weight distribution of RM codes. We obtain such bounds extending the recent bounds from constant degree to linear degree polynomials.
Loss of miR-107, miR-181c and miR-29a-3p Promote Activation of Notch2 Signaling in Pediatric High-Grade Gliomas (pHGGs)

The mechanisms by which microRNAs control pediatric high-grade gliomas (pHGGs) have yet to be fully elucidated. Our studies of patient-derived pHGG tissues and of the pHGG cell line KNS42 revealed down-regulation in these tumors of three microRNAs, specifically miR-107, miR-181c, and miR-29a-3p. This down-regulation increases the proliferation of KNS42 cells by de-repressing expression of the Notch2 receptor (Notch2), a validated target of miR-107 and miR-181c and a putative target of miR-29a-3p. Inhibition (either pharmacologic or genetic) of Notch2 or re-expression of the implicated microRNAs (all three combined but also individually) significantly reduced KNS42 cell proliferation. These findings suggest that Notch2 pathway activation plays a critical role in pHGGs growth and reveal a direct epigenetic mechanism that controls Notch2 expression, which could potentially be targeted by novel forms of therapy for these childhood tumors characterized by high-morbidity and high-mortality.
“It’s My Place”: Student Perspectives on Urban School Effectiveness

This study investigated how graduates of an urban alternative school understood, interpreted, and compared their experiences in previous schools that they considered ineffective with their experiences at an effective alternative school. This study found that students find those schools effective that create or allow spaces where they can be empowered, leading to a sense of place. Students’ ownership or affinity to school spaces that lead them to refer to school as “my place” derived from school practices that were instrumental in promoting a sense of identification, commitment, integration, and alliances among students and faculty at the school. Based on the findings of the study, this article argues that for urban schools to be effective for students at risk, they not only need to focus on caring relationships and diverse learning experiences, they also need to create the space to foster a sense of “my place” for students.
Early teacher perceptions and later student academic achievement

The researchers explore relationships between preschool teachers' appraisals of intelligence, concurrent child characteristics, and future high school performance in a core sample of 110 4-year-olds. Children with higher socioeconomic status (SES) and those perceived as assertive and independent were judged by teachers more positively than IQ score predicted; conversely, low SES and perceived immaturity were associated with more negative teacher judgments than IQ score predicted. After controlling for SES, preschool teachers' over- and underestimates of intelligence relative to IQ score significantly predicted grade point average (GPA) and Scholastic Aptitude Test (SAT) test-taking 14 years later. The relationship between teacher ratings and GPA was strongest for children whose ability was underestimated. Teacher predictions were weakest in homes rated by observers as more orderly or with mothers who were more career or community active. Prescient versus influential interpretations of these findings are discussed.
Sib-Pair Analysis of Adenosine Deaminase Locus in NIDDM

Recently, linkage between the ADA gene locus and MODY, a subtype of NIDDM, has been reported. The possibility that the region of chromosome 20q containing the ADA locus also may play a role in susceptibility to NIDDM needs to be investigated. Therefore, we examined the linkage between the ADA locus and NIDDM in affected siblings of 50 European white diabetic pedigrees—21 Italian and 29 British. Departure from independent segregation of the disease and an Alu VpA polymorphism within the 5' flanking region of the ADA locus was tested in the affected sib-pairs with the APM statistical method. After DNA amplification by the PCR and PAGE, five alleles were identified in the ALU VpA tract at the ADA locus in the two populations. Allele frequencies did not differ significantly between the two populations (X2 = 2.426, P > 0.05 [NS]). Analysis of the 50 diabetic sib sets, and independently of the Italian and British groups of affected sib pairs, revealed no segregation distortion between the marker locus and NIDDM. We conclude that mutations within or around the ADA locus are unlikely to play a major role in the etiology of NIDDM.