Miracle-dz/UniFAR-FTUs huggingface dataset:
Nerve Sources for Facial Reanimation With Muscle Transplant in Patients With Unilateral Facial Palsy: Clinical Analysis of 3 Techniques

Ninety-one patients with long-standing unilateral facial palsy and submitted to reanimation of the face with muscle transplant were divided into 3 nonrandomized groups: group I: 2-stage facial reanimation, cross face followed by gracilis muscle transplant, 58 patients; group II: 1-stage reanimation with latissimus dorsi muscle transplant, 11 patients (a branch of the facial nerve on the nonparalyzed side of the face was used as the nerve source for reanimation in groups I and II); group III: 1-stage reanimation with gracilis muscle transplant and neural coaptation of the respective nerve and the ipsilateral masseteric branch of the trigeminal nerve, 22 patients. No microvascular complications were observed. The average interval between surgery and initial muscle contractions was 11.1 months, 7.2 months, and 3.7 months in group I, group II, and group III, respectively. The quality (intensity and shape) of the smile, voluntary or involuntary, obtained on the reanimated side in relation to the unaffected side was considered good or excellent in 53.4%, 54.5%, and 86.3% of the patients in groups I, II, and III, respectively. In group I, the average age of the patients with excellent or good results (19.8 + 10.5 years) was significantly lower than that of the patients with fair or poor results or absence of movement (36.5 + 13.3 years). The smile was considered emotional or involuntary in 34% of the patients in group I and 45% in group II. Most of the patients in each group were only able to produce “voluntary smiles”. Crossed synkinesis with lip puckering was observed in 48% of the patients in group I and 90% in group II. The results obtained with 1-stage facial reanimation with masseteric nerve were more uniform and predictable than those obtained with the other techniques evaluated in this study.
Full access to medical records does not modify anxiety in cancer patients

Information is crucial for increasing the patients' empowerment and autonomy in relevant decision‐making processes, especially in malignant diseases. However, the extent to which information should be delivered is debated. The objective of this study was to assess the impact of providing systematic full access (SFA) to the medical record on anxiety, quality of life, and satisfaction.
Exercises With Increasing Loads on the Biceps Rehabilitation Exercises for Athletes With Biceps Disorders and SLAP Lesions : A Continuum

http://ajs.sagepub. com/content/early/2014/03/18/0363546514526692 The online version of this article can be found at: DOI: 10.1177/0363546514526692 published online March 21, 2014 Am J Sports Med Ann M. Cools, Dorien Borms, Simon Cottens, Marcia Himpe, Stijn Meersdom and Barbara Cagnie Exercises With Increasing Loads on the Biceps Rehabilitation Exercises for Athletes With Biceps Disorders and SLAP Lesions: A Continuum of
Loss and Climate Change: The Cost of Parallel Narratives

Climate change discourses present two parallel narratives—one about the problems of climate change and the other about the solutions. In narratives about the problem of climate change, loss features dramatically and terrifyingly but is located in the future or in places remote from Western audiences. In narratives about solutions, loss is completely excised. This article suggests that this division into parallel narratives is the result of a defensive process of splitting and projection, which protects the public from the need to truly face and mourn the losses associated with climate change. Its effect is to produce monstrous and terrifying images of the future accompanied by bland and ineffective proposals for change now. A more sophisticated understanding of the processes of loss and mourning, which allowed them to be restored to public narratives, would help to release energy for realistic and lasting programmes of change. Psychoanalytic models of grief and loss may be particularly helpful in achievin.
Evaluating the effectiveness of enhancing resilience in human service professionals using a retreat-based Mindfulness with Metta Training Program: A randomised control trial

This paper explores the feasibility of a brief Mindfulness with Metta Training Program (MMTP), targeting the enhancement of mindfulness and self-compassion in a retreat format, as a means of increasing resilience in human services professionals. In this randomised control trial, 44 human services professionals were randomly allocated either to a MMTP retreat group or to a control group. Following the MMTP intervention, no significant differences between the retreat and control groups were found on resilience, mindfulness and self-compassion variables. However, significant improvements were observed over time for the retreat group for mindfulness and self-compassion at one and four months and for resilience at four-months post MMTP intervention. The results of this pilot study show that MMTP in a retreat format is a promising method of increasing resilience, mindfulness and self-compassion in human services professionals.
A framework to measure user experience of interactive online products

Over the past years, User eXperience (UX) research in the academic community has created various approaches to UX evaluation frameworks. However, industry adopted these approaches rather vaguely into product development. Due to this existing gap between research academics and companies, this paper concerns the question of how UX evaluation can be integrated into the software engineering process of interactive online products. Therefore, influencing factors that need to be measured, including human and system aspects, emotions, a spatiotemporal dimension and motivation, were analyzed. In order to evaluate these factors transparently and to link UX factors to actual product functionalities, existing evaluation methods to collect qualitative and quantitative user data were selected and joint to an evaluation method set. First experiences of using the UX framework and this method set by means of a new web-community concept will be outlined and discussed.
Mycobacterium avium Genes Associated with the Ability To Form a Biofilm

ABSTRACT Mycobacterium avium is widely distributed in the environment, and it is chiefly found in water and soil. M. avium, as well as Mycobacterium smegmatis, has been recognized to produce a biofilm or biofilm-like structure. We screened an M. avium green fluorescent protein (GFP) promoter library in M. smegmatis for genes involved in biofilm formation on polyvinyl chloride (PVC) plates. Clones associated with increased GFP expression ≥2.0-fold over the baseline were sequenced. Seventeen genes, most encoding proteins of the tricarboxylic acid (TCA) cycle and GDP-mannose and fatty acid biosynthesis, were identified. Their regulation in M. avium was confirmed by examining the expression of a set of genes by real-time PCR after incubation on PVC plates. In addition, screening of 2,000 clones of a transposon mutant bank constructed using M. avium strain A5, a mycobacterial strain with the ability to produce large amounts of biofilm, revealed four mutants with an impaired ability to form biofilm. Genes interrupted by transposons were homologues of M. tuberculosis 6-oxodehydrogenase (sucA), enzymes of the TCA cycle, protein synthetase (pstB), enzymes of glycopeptidolipid (GPL) synthesis, and Rv1565c (a hypothetical membrane protein). In conclusion, it appears that GPL biosynthesis, including the GDP-mannose biosynthesis pathway, is the most important pathway involved in the production of M. avium biofilm.
Family, kinship and collectivity as systems of support in pre-industrial Europe: a consideration of the ‘nuclear-hardship’ hypothesis

La vie dans les maisons à famille simple (familles nucléaires) prive beaucoup d'individus de support familial. L'hypothese de la privation nucléaire affirme que plus il existe de maisons à famille simple dans une société, plus ces individus auront besoin du support de la collectivité, c'est-à-dire les organisations de charité telles que l'Eglise, les municipalités et l'Etat. On a particulièrement pris en considération le support provenant des membres de la famille autres que ceux avec qui l'individu réside et l'ampleur du transfert à travers la collectivité. On conclut qu'en Angleterre et dans le Nord-Ouest de l'Europe, où la maison à famille simple prédominait, les transferts à travers la collectivité avient effectivement une grande importance dans ce but à l'époque pré-industrielle et les transferts à partir de la famille étaient peu importants. Cependant, les transferts à travers la collectivité étaient également considérables dans les autres régions et on ne peut pas affirmer que la proportion pour l'hypothèse de la privation nucléaire en tant que telle ait été clairement démontrée. In einer Kleinfamilie (Kernfamilie) zu leben, bedeutet für viele einen Mangel an Unterstützung durch die Familie. Die Hypothese der Kernfamilienproblematik besagt, dass je grösser die Anzahl der Kleinfamilien in einer Gesellschaft ist, desto wichtiger wird für das einzelne Familienmitglied die Unterstützung durch das Kollektiv, d.h. durch Wohlfahrtsorganisationen wie Kirche, Gemeinde und Staat. Besondere Beachtung findet die Unterstützung, die dem einzelnen aus dem nicht im selben Haushalt lebenden weiteren Verwandtenkreis zukommt und der Umfang der Übertragung durch das Kollektiv. Die Schlussfolgerung ist, dass in England und Nordwesteuropa, wo die Kleinfamilie vorherrschte, in der vorindustriellen Zeit Übertragunger durch das Kollektiv für diesen Zweck tatsächlich von grosser Wichtigkeit, Übertragungen aus dem Verwandtenkreis dagegen unbedeutend waren. Übertragungen durch das Kollektiv waren aber auch in anderen Bereichen beträchtlich und man kann nicht sagen, dass der Anteil, der f¨r die Hypothese der Kernfamilienproblematik von Belang wäre, eindeutig bewiesen worden ist.
Systolic Blood Pressure Variation and Mean Heart Rate Is Associated With Cognitive Dysfunction in Patients With High Cardiovascular Risk

Abstract—Elevated systolic blood pressure (SBP) correlates to cognitive decline and incident dementia. The effects of heart rate (HR), visit to visit HR variation, and visit to visit SBP variation are less well established. Patients without preexisting cognitive dysfunction (N=24 593) were evaluated according to mean SBP, SBP visit to visit variation (coefficient of variation [standard deviation/mean×100%], CV), mean HR, and visit to visit HR variation (HR-CV) in the Ongoing Telmisartan Alone and in Combination with Ramipril Global Endpoint Trial and the Telmisartan Randomized Assessment Study in ACE Intolerant Subjects with Cardiovascular Disease. Cognitive function was assessed with mini mental state examination. Cognitive dysfunction (fall in mini mental state examination ⩽24 points), important cognitive decline (drop of ≥5 points), and cognitive deterioration (drop of >1 point per year or decline to <24 points) were assessed. SBP and HR were measured over 10.7±2.2 (mean±SD) visits. Mean SBP, mean HR, and SBP-CV were associated with cognitive decline, dysfunction, and deterioration (all P<0.01, unadjusted). After adjustment, only SBP-CV (P=0.0030) and mean HR (P=0.0008) remained predictors for cognitive dysfunction (odds ratios [95% confidence intervals], 1.32 [1.10–1.58] for 5th versus 1st quintile of SBP-CV and 1.40 [1.18–1.66] for 5th versus 1st quintile of mean HR). Similar effects were observed for cognitive decline and deterioration. SBP-CV and mean HR showed additive effects. In conclusion, SBP-CV and mean HR are independent predictors of cognitive decline and cognitive dysfunction in patients at high CV risk. Clinical Trial Registration—URL: http://www.clinicaltrials. gov. Unique identifier: NCT 00153101.
Moth sex chromatin probed by comparative genomic hybridization (CGH).

Abstract: Comparative genomic hybridization (CGH) with a probe mixture of differently labeled genomic DNA from females and males highlighted the W chromosomes in mitotic plates and the W chromatin in polyploid interphase nuclei of the silkworm Bombyx mori, the flour moth Ephestia kuehniella, and the wax moth Galleria mellonella. The overproportionate fluorescence signal indicated an accumulation of repetitive sequences in the respective W chromosomes. Measurements of the fluorescence signals revealed two components, one that is present also in male DNA (non-W chromosomes) and another one that is present only in or preponderantly in female DNA (W chromosomes). While the W chromosomes of E. kuehniella and G. mellonella had both components, that of B. mori appeared to lack the latter component. Our results show that CGH can be applied to obtain a first estimate of the sequence composition of sex chromosomes in species from which otherwise little is known on the molecular level.
Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism

The major obstacle in cancer treatment is the resistance of cancer cells to therapies. Nrf2 is a transcription factor that regulates a cellular defense response and is ubiquitously expressed at low basal levels in normal tissues due to Keap1-dependent ubiquitination and proteasomal degradation. Recently, Nrf2 has emerged as an important contributor to chemoresistance. High constitutive expression of Nrf2 was found in many types of cancers, creating an environment conducive for cancer cell survival. Here, we report the identification of brusatol as a unique inhibitor of the Nrf2 pathway that sensitizes a broad spectrum of cancer cells and A549 xenografts to cisplatin and other chemotherapeutic drugs. Mechanistically, brusatol selectively reduces the protein level of Nrf2 through enhanced ubiquitination and degradation of Nrf2. Consequently, expression of Nrf2-downstream genes is reduced and the Nrf2-dependent protective response is suppressed. In A549 xenografts, brusatol and cisplatin cotreatment induced apoptosis, reduced cell proliferation, and inhibited tumor growth more substantially when compared with cisplatin treatment alone. Additionally, A549-K xenografts, in which Nrf2 is expressed at very low levels due to ectopic expression of Keap1, do not respond to brusatol treatment, demonstrating that brusatol-mediated sensitization to cisplatin is Nrf2 dependent. Moreover, a decrease in drug detoxification and impairment in drug removal may be the primary mechanisms by which brusatol enhances the efficacy of chemotherapeutic drugs. Taken together, these results clearly demonstrate the effectiveness of using brusatol to combat chemoresistance and suggest that brusatol can be developed into an adjuvant chemotherapeutic drug.
In vitro activity of midecamycin, a new macrolide antibiotic

Midecamycin, an acetoxy-substituted macrolide antibiotic, was tested against gram-positive and gram-negative bacteria. It inhibited the majority of streptococci, staphylococci, and strains of Haemophilus and Listeria at concentrations of less than 3.1 micrograms/ml. It was less active than erythromycin, and it failed to inhibit erythromycin-resistant isolates.
The role of contact partners’ gender in moderating the effect of positive contact on intergroup attitudes: A theoretical framework

Decades of research have indicated that positive contact with sexual minorities is reliably associated with reduced sexual prejudice among heterosexuals (see Pettigrew & Tropp, 2006; Smith, Axelton, & Saucier, 2009). Despite this extensive literature, the gender of contact partners has been largely overlooked. In the present article, we propose a novel theoretical framework to argue that the relationship between positive contact and intergroup attitudes may vary as functions of the gender of the heterosexual contact partners (i.e., heterosexual men versus heterosexual women) and the gender of the sexual minority contact partners (i.e., gay men versus lesbian women). Drawing on research examining core moderators of contact effects (Hodson, 2011; Hodson, Costello, & MacInnis, 2013) and gender differences in attitudes toward gay men and lesbian women (Herek, 2000a; Kite & Whitley, 1996; LaMar & Kite, 1998), we contend that for heterosexual men, positive contact with gay men might be more effective in improving intergroup attitudes than positive contact with lesbian women. Conversely, for heterosexual women, the beneficial effect of positive contact with lesbian women might be more pronounced than the beneficial effect of positive contact with gay men. We also propose that attitudes toward gender-role violations, knowledge about the out-group, empathy, and intergroup anxiety should emerge as the key mediators of the positive contact-intergroup attitudes relationship.
Physically-Correct Light-Field Factorization for Perspective Images

SUMMARY A layered light-ﬁeld display based on light-ﬁeld factorization is considered. In the original work, the factorization is formulated under the assumption that the light ﬁeld is captured with orthographic cameras. In this paper, we introduce a generalized framework for light-ﬁeld factorization that can handle both the orthographic and perspective camera projection models. With our framework, a light ﬁeld captured with perspective cameras can be displayed accurately.
MINDFULNESS AT WORK

In this chapter, we argue that state and trait mindfulness and mindfulness-based practices in the workplace should enhance employee outcomes. First, we review the existing literature on mindfulness, provide a brief history and definition of the construct, and discuss its beneficial effects on physical and psychological health. Second, we delineate a model of the mental and neurobiological processes by which mindfulness and mindfulness-based practices improve self-regulation of thoughts, emotions, and behaviors, linking them to both performance and employee well-being in the workplace. We especially focus on the power of mindfulness, via improved self-regulation, to enhance social relationships in the workplace, make employees more resilient in the face of challenges, and increase task performance. Third, we outline controversies, questions, and challenges that surround the study of mindfulness, paying special attention to the implications of unresolved issues for understanding the effects of mindfulness at work. We conclude with a discussion of the implications of our propositions for organizations and employees and offer some recommendations for future research on mindfulness in the workplace.
Structural Brain Abnormalities in Attention-Deficit/Hyperactivity Disorder: A Voxel-based MRI Study in Adult Patients

Objective: Most structural neuroimaging studies of subjects with attention-deficit/hyperactivity disorder (ADHD) have been conducted in children. The most replicated findings in ADHD children include significantly smaller volumes in the prefrontal cortex, basal ganglia, corpus callosum and cerebellum. In the present study, we investigated structural brain abnormalities in adult subjects with ADHD using voxel-based morphometry (VBM). Methods: 25 ADHD patients (14 males, mean age 32 years) and 25 age- and gender matched healthy control subjects (Table 1) underwent a detailed clinical interview as well as neuropsychological investigation of intelligence, memory, attention, psychomotor performance and executive functioning. We acquired MPRAGE (Magnetization Prepared Rapid Gradient Echo)-sequences for high resolution structural magnetic resonance imaging (MRI) on a 1.5 T scanner. The MRI data sets were first normalized to a standard template using SPM5 software. Images were segmented into gray matter (GM), white matter and cerebrospinal fluid (Figure 1) and smoothed with an 8mm FWHM kernel. Voxel-wise comparisons were then performed between groups with two contrasts (2 sample unpaired t-test) to test for significant differences of local brain tissue concentration and volume. Following established procedures, contrast maps were thresholded at a P <0.001 without correction for multiple comparisons and the extent threshold for significant clusters was set to 100 voxels. Results: Typical group differences in ADHD measures were found (Table 1). Voxel-based morphometry analysis revealed regional volume differences in the gray matter of the right cerebellum showing significantly smaller GM volume in ADHD patients (Figure 2; peak voxel coordinates MNI 16,-60,-38; cluster extend 125 voxels). Conclusion: Our results provide additional support for the role of cerebellar abnormalities in the pathophysiology of ADHD. Together with previous findings, there is growing evidence for the impact of the cerebellar-prefrontal-striatal network in ADHD pathophysiology. References: [1] Ashburner J, Friston KJ. , 2000. Neuroimage 11:805–821. [2] Seidman LJ, et al., 2005. Biol Psychiatry 57:1263–1272. [3] Seidman LJ, et al., 2006. Biol Psychiatry 60:1071–1080. [4] Valera EM, et al., 2007. Biol Psychiatry 61:1361–1369. Table 1
Compassion interventions: The programmes, the evidence, and implications for research and practice

PURPOSE Over the last 10-15 years, there has been a substantive increase in compassion-based interventions aiming to improve psychological functioning and well-being. METHODS This study provides an overview and synthesis of the currently available compassion-based interventions. What do these programmes looks like, what are their aims, and what is the state of evidence underpinning each of them? RESULTS This overview has found at least eight different compassion-based interventions (e.g., Compassion-Focused Therapy, Mindful Self-Compassion, Cultivating Compassion Training, Cognitively Based Compassion Training), with six having been evaluated in randomized controlled trials, and with a recent meta-analysis finding that compassion-based interventions produce moderate effect sizes for suffering and improved life satisfaction. CONCLUSIONS Although further research is warranted, the current state of evidence highlights the potential benefits of compassion-based interventions on a range of outcomes that clinicians can use in clinical practice with clients. PRACTITIONER POINTS There are eight established compassion intervention programmes with six having RCT evidence. The most evaluated intervention to date is compassion-focused therapy. Further RCTs are needed in clinical populations for all compassion interventions. Ten recommendations are provided to improve the evidence-base of compassion interventions.
Clinical Outcome of Laryngotracheal Separation for Intractable Aspiration Pneumonia

Objectives: To confirm that laryngotracheal separation (LTS) is a satisfactory treatment for patients with intractable aspiration pneumonia, even though it does not require tracheoesophageal anastomosis. Study Design: Retrospective. Methods: Nine patients with intractable aspiration pneumonia underwent LTS at our institution from 1996 to 1999. Two patients underwent postoperative barium swallow radiography. Results: Neither halitosis nor stimulation of the cough reflex occurred due to pooled secretions in the blind pouch of the proximal tracheal segment. Barium swallow radiography confirmed that the secretions drained within 40 min by swallowing or a change in patient position. Conclusion: LTS is a satisfactory solution to the problem of chronic aspiration. Neither pooled secretions in the proximal tracheal segment nor fistula formation were significant postoperative problems.