Miracle-dz/UniFAR-FTUs huggingface dataset:
Predicting treatment outcomes of major depressive disorder by early improvement in painful physical symptoms: a pooled analysis of double-blind, placebo-controlled trials of duloxetine

Objective We determined if early improvement in painful physical symptoms (PPS) can be a predictor of remission in the treatment of major depressive disorder (MDD). Methods We included randomized, double-blind, parallel-group clinical trials of duloxetine (40–60 mg/day) versus placebo for the acute treatment of MDD with associated PPS. Only those studies using the Montgomery–Åsberg Depression Rating Scale (MADRS) and the Brief Pain Inventory – Short Form (BPI-SF) were included. Three studies met all criteria and included male or female outpatients aged ≥18 years who met the diagnostic criteria for MDD, had a MADRS total score ≥20, and had at least moderate pain (BPI-SF average pain score ≥3). Positive predictive values (PPVs) and negative predictive values (NPVs) of early improvement in PPS for remission were analyzed. PPVs were the proportion of patients with remission (MADRS total score ≤10) at week 8 out of patients who experienced early improvement in BPI-SF average pain score (≥30% decrease from baseline at week 1, 2, or 4). NPVs were the proportion of patients without remission (MADRS total score >10) at week 8 out of patients who did not experience early improvement in PPS. Results Data from 1,320 patients were analyzed (duloxetine N=641 and placebo N=679). The overall remission (MADRS total score ≤10 at week 8) rate for the duloxetine group was significantly higher than the placebo group (38.5% vs 21.8%; P<0.0001). For both treatment groups, PPVs of early improvement in BPI-SF (30% improvement from baseline) were higher than the overall remission rate for all weeks examined (weeks 1, 2, and 4); in general, NPVs of early improvement in BPI-SF for nonremission were higher than the overall nonremission rate. Conclusion Early improvement in PPS can be a useful clinical indicator of subsequent treatment outcome for MDD patients with associated PPS.
Efficacy of mosquito netting for sustainable small holders' cabbage production in Africa.

The efficacy of a mosquito netting to protect cabbages, Brassica oleracea L. , against pests was investigated in field trials in Benin, West Africa. A polyester net covered the plants at night by using a wood armature. The net was removed during the day to prevent overheating and excessive shade, both problems of insect-proof screens used under tropical conditions. The number of all lepidopteran larvae with netting protection and foliar insecticide sprays was significantly lower than the unprotected control. The number of diamondback moth, Plutella xylostella (L.), was significantly lower with netting protection compared with foliar insecticide sprays and control. Netting treated with deltamethrin gave total protection of young plants against the aphid Lipaphis erysimi (Kaltenbach). At harvest, the number of marketable cabbages protected with untreated netting was significantly higher compared with the production with foliar insecticide sprays. The protection of cabbages with netting can be an economically viable method. Considering the price of cabbages on local markets (US dollars 1/unit), the net returns per 100 m2 were US dollars 247 by using netting, US dollars 149 by using insecticides, and US dollars 117 for controls. The net returns for using netting are based on replacing the netting each crop cycle. But netting can be reused several times, depending upon conditions, increasing the profit margin. The netting protection may be an alternative to the growing unsustainable practices of vegetable cropping in peri-urban areas of tropical countries.
Iron-Oxide Pigments Obtained from Sewage Sludge: Properties, Structure, Phase Transformation

The paper presents chemical, physical, and physicochemical investigations of sewage sludge and iron-oxide pigments produced therefrom. Gravimetric, X-ray phase, and thermal analyses and scanning electron microscopy were carried out in certified laboratories. Experimental results are given for iron-containing sewage sludge produced by the water-treatment plant and taken from water collection filters of Tomsk groundwater sources. It is shown that at heating iron-containing sewage sludge up to 800 oС, a brick-red pigment is formed having the specific surface area of 9,8 m2/g that corresponds to the theoretical particle size of 124 nm. A flow-chart is suggested for the production of iron-oxide pigments obtained from sewage sludge, and the raw material compositions are designed for construction industry applications. The suggested cement-sand colored compositions of materials and products have passed the evaluation tests at OOO Akvatom (Tomsk, Russia), and their high service properties (strength, water-and frost-resistance) are experimentally supported.
Speech Adaptation to Kinematic Recording Sensors Elise

Speech Adaptation to Kinematic Recording Sensors Elise Hansen Hunter Department of Communication Disorders, BYU Master of Science This thesis examined the time course of speech adaptation prior to data collection when using an electromagnetic articulograph to measure speech articulator movements. The stimulus sentence and electromagnetic sensor placement were designed to be sensitive to changes in the fricatives /s/ and /ʃ/. Twenty native English speakers read aloud stimulus sentences before the attachment of six electromagnetic sensors, immediately after attachment, and again at 5, 10, 15 and 20 minutes after attachment. Participants read aloud continuously between recordings to encourage adaptation to the presence of the sensors. Audio recordings were rated by 20 native English listeners who were not part of the production study. After listening to five practice samples, these participants rated 150 stimuli (31 repeat samples) using a visual analog scale (VAS) with the endpoints labeled as precise and imprecise. An acoustic analysis of the recordings was done by segmenting the fricatives /s/ and /ʃ/ from the longer recording and computing spectral center of gravity and spectral standard deviation in Hertz. Durations of /s/, /ʃ/ and the sentence were also measured. Results of both perceptual and acoustic analysis revealed a change in speech precision over time, with all post attachment recordings receiving lower perceptual scores. Precision ratings beyond the 10 minute recording remained steady. It can be concluded from the results that participants reached a height of adaptation after 10 minutes of talking with kinematic recording sensors attached, and that after the attachment of sensors, speech production precision did not at any point return to pre attachment levels.
Evidence for carbon sequestration by agricultural liming

Agricultural lime can be a source or a sink for CO2, depending on whether reaction occurs with strong acids or carbonic acid. Here we examine the impact of liming on global warming potential by comparing the sum of Ca2+ and Mg2+ to carbonate alkalinity in soil solutions beneath unmanaged vegetation versus limed row crops, and of streams and rivers in agricultural versus forested watersheds, mainly in southern Michigan. Soil solutions sampled by tension indicated that lime can act as either a source or a sink for CO2. However, infiltrating waters tended to indicate net CO2 uptake, as did tile drainage waters and streams draining agricultural watersheds. As nitrate concentrations increased in infiltrating waters, lime switched from a net CO2 sink to a source, implying nitrification as a major acidifying process. Dissolution of lime may sequester CO2 equal to roughly 25–50% of its C content, in contrast to the prevailing assumption that all of the carbon in lime becomes CO2. The ∼30 Tg/yr of agricultural lime applied in the United States could thus sequester up to 1.9 Tg C/yr, about 15% of the annual change in the U.S. CO2 emissions (12 Tg C/yr for 2002–2003). The implications of liming for atmospheric CO2 stabilization should be considered in strategies to mitigate global climate change.
Addressing Mental Health Needs: Perspectives of African Americans Living in the Rural South.

OBJECTIVE Rural African Americans are disproportionately affected by social stressors that place them at risk of developing psychiatric disorders. This study aimed to understand mental health, mental health treatment, and barriers to treatment from the perspective of rural African-American residents and other stakeholders in order to devise culturally acceptable treatment approaches. METHODS Seven focus groups (N=50) were conducted with four stakeholder groups: primary care providers, faith community representatives, college students and administrators, and individuals living with mental illness. A semistructured interview guide was used to elicit perspectives on mental health, mental health treatment, and ways to improve mental health in rural African-American communities. Inductive analysis was used to identify emergent themes and develop a conceptual model grounded in the textual data. RESULTS Stressful living environments (for example, impoverished communities) and broader community-held beliefs (for example, religious beliefs and stigma) had an impact on perceptions of mental health and contributed to barriers to help seeking. Participants identified community-level strategies to improve emotional wellness in rural African-American communities, such as providing social support, improving mental health literacy, and promoting emotional wellness. CONCLUSIONS Rural African Americans experience several barriers that impede treatment use. Strategies that include conceptualizing mental illness as a normal reaction to stressful living environments, the use of community-based mental health services, and provision of mental health education to the general public may improve use of services in this population.
Influence of Concrete Properties and Restraint on Shrinkage Crack Formation

This article aims to investigate four parameters of concrete properties and restraint on shrinkage crack formation, specifically concrete strength, relative humidity, curing period and the restrained level via the time dependent model. The time dependent model represents in fact two models: 1) The Rigid-Body-Spring Model (RBSM) (structural-based) and 2) modified solidification model (material-based). After these variables were analyzed, it was evident that cracking dates, firstly, were not in proportion to the changes of concrete strength and relative humidity. Therefore, the proper value of concrete strength and relative humidity should be examined before designing the structure. Secondly, it is not suitable to apply comparative results between tensile stress and tensile strength when basing a prediction on the cracking times, since stress histories and accumulated damages were the major causes of concrete cracking. Thirdly, studies have shown the process of curing, as it exceeds the suitable period, will not only waste time but will also show signs of early cracks. Finally lower restrained level had caused a delay in cracking times.
Incremental Validity of the Trait Emotional Intelligence Questionnaire–Short Form (TEIQue–SF)

This study examined the incremental validity of the adult short form of the Trait Emotional Intelligence Questionnaire (TEIQue–SF) in predicting 7 construct-relevant criteria beyond the variance explained by the Five-factor model and coping strategies. Additionally, the relative contributions of the questionnaire's 4 subscales were assessed. Two samples of Canadian university students completed the TEIQue–SF, along with measures of the Big Five, coping strategies (Sample 1 only), and emotion-laden criteria. The TEIQue–SF showed consistent incremental effects beyond the Big Five or the Big Five and coping strategies, predicting all 7 criteria examined across the 2 samples. Furthermore, 2 of the 4 TEIQue–SF subscales accounted for the measure's incremental validity. Although the findings provide good support for the validity and utility of the TEIQue–SF, directions for further research are emphasized.
Detection and Fine-Grained Classification of Cyberbullying Events

In the current era of online interactions, both positive and negative experiences are abundant on the Web. As in real life, negative experiences can have a serious impact on youngsters. Recent studies have reported cybervictimization rates among teenagers that vary between 20% and 40%. In this paper, we focus on cyberbullying as a particular form of cybervictimization and explore its automatic detection and fine-grained classification. Data containing cyberbullying was collected from the social networking site Ask.fm. We developed and applied a new scheme for cyberbullying annotation, which describes the presence and severity of cyberbullying, a post author's role (harasser, victim or bystander) and a number of fine-grained categories related to cyberbullying, such as insults and threats. We present experimental results on the automatic detection of cyberbullying and explore the feasibility of detecting the more fine-grained cyberbullying categories in online posts. For the first task, an F-score of 55.39% is obtained. We observe that the detection of the fine-grained categories (e.g. threats) is more challenging, presumably due to data sparsity, and because they are often expressed in a subtle and implicit way.
Identification of a spin-coupled Mo(III) in the nitrogenase iron–molybdenum cofactor

Nitrogenase is a complex enzyme that catalyzes the formation of ammonia utilizing a MoFe7S9C cluster. The presence of a central carbon atom was recently revealed, finally completing the atomic level description of the active site. However, important prerequisites for understanding the mechanism – the total charge, metal oxidation states and electronic structure are unknown. Herein we present high-energy resolution fluorescence detected Mo K-edge X-ray absorption spectroscopy of nitrogenase. Comparison to FeMo model complexes of known oxidation state indicates that the Mo in the FeMo cofactor of nitrogenase is best described as Mo(III), in contrast to the universally accepted Mo(IV) assignment. The oxidation state assignment is supported by theoretical calculations, which reveal the presence of an unusual spin-coupled Mo(III) site. Although so far Mo(III) was not reported to occur in biology the suggestion raises interesting parallels with the known homogenous Mo catalysts for N2 reduction, where a Mo(III) compound is the N2-binding species. It also requires a reassignment of the Fe oxidation states in the cofactor.
Abrasion Testing of Products Containing Nanomaterials, SOP-R-2: Scientific Operating Procedure Series: Release (R)

Abstract : Abrasion is an important consideration for the potential release of nanoparticles during the service life of a nanotechnology. This SOP presents a general method for abrading a material using a rotating sample platform in contact with a weighted sandpaper fixture. Particles collected with this method are analyzed with a condensation particle counter (CPC) and a fast mobility particle sizer (FMPS), with additional particles collected on in-line filters for further analysis. The abrading process is carried out in a particle-free environment and released particles are moved by a defined airflow from the chamber to the collection/analysis apparatus. Particle release is monitored in real time by the CPC (10nm - 1 micrometer) and FMPS (32 particle size bins from 5-550 nm), and further characterization of filter-collected particles can be accomplished post-testing.
Effects of exercise intensity on postexercise hypotension after resistance training session in overweight hypertensive patients

Among all nonpharmacological treatments, aerobic or resistance training (RT) has been indicated as a significantly important strategy to control hypertension. However, postexercise hypotension responses after intensity alterations in RT are not yet fully understood. The purpose of this study was to compare the outcomes of differing intensities of RT on hypertensive older women. Twenty hypertensive older women participated voluntarily in this study. After a maximum voluntary contraction test (one repetition maximum) and determination of 40% and 80% experimental loads, the protocol (3 sets/90″ interset rest) was performed in a single session with the following exercises: leg press, leg extension, leg curl, chest press, elbow flexion, elbow extension, upper back row, and abdominal flexion. Systolic and diastolic blood pressures were evaluated at rest, during exercise peak, and after 5, 10, 15, 30, 45, and 60 minutes of exercise and compared to the control. Both experimental loads were effective (P<0.01) in promoting postexercise systolic hypotension (mmHg) compared to controls, after 30, 45, and 60 minutes, respectively, at 40% (113±2, 112±4, and 110±3 mmHg) and 80% (111±3, 111±4, and 110±4 mmHg). Both procedures promoted hypotension with similar systolic blood pressures (40%: −11%±1.0% and 80%: −13%±0.5%), mean arterial blood pressures (40%: −12%±5.5% and 80%: −12%±3.4%), and rate-pressure products (40%: −15%±2.1% and 80%: −17%±2.4%) compared to control measures (systolic blood pressure: 1%±1%, mean arterial blood pressure:\ 0.6%±1.5%, rate-pressure product: 0.33%±1.1%). No differences were found in diastolic blood pressure and heart rate measures. In conclusion, hypertensive older women exhibit postexercise hypotension independently of exercise intensity without expressed cardiovascular overload during the session.
Therapeutic effects of oral dimethyl fumarate on stroke induced by middle cerebral artery occlusion: An animal experimental study.

BACKGROUND Dimethyl fumarate (DMF) has immune-modulatory and neuro-protective characteristics that can be used for treatment of acute ischemic stroke. OBJECTIVE To investigate the therapeutic effects of DMF on histological and functional recovery of rats after transient middle cerebral artery (MCA) occlusion. METHODS 22 Sprague-Dawley male rats weighing 275-300 g were randomized into three groups by block randomization. In the sham group (n = 7), the neck was opened, but neither MCA was occluded, nor any drug was administered.The control group (n = 7) was treated with vehicle (methocel) by gavage for 14 days after MCA occlusion. In the DMF-treated group (n = 8), treatment was performed with 15 mg/kg body weight dimethyl fumarate twice a day for 14 days after MCA occlusion. Transient occlusion of the right MCA was performed by intraluminal thread method in the DMF-treated and the control group. Neurological deficit score (NDS), pole test, and adhesive removal test were performed before the surgery, and on post-operative Days 0, 3, 5, 7, 10, and 14. After the final behaviour test, the animals' brains were perfused and removed. Brains were frozen and sectioned serially and coronally using a cryostat. Infract volume and brain volume were estimated by stereology. RESULTS The percentage of infarct volume was significantly lower in DMF-treated animals (5.76%) than in the control group (22.39%) (P < 0.0001). Regarding behavioural tests, the DMF-treated group showed better function in NDS on Days 7 (P = 0.041) and 10 (P = 0.046), but not in pole and adhesive removal tests. There was no significant correlation between behavioural tests and histological results. CONCLUSION Dimethyl fumarate could be beneficial as a potential neuroprotective agent in the treatment of stroke.
Sex Steroid Hormones and Fracture in a Multiethnic Cohort of Women: The Women’s Health Initiative Study (WHI)

Context We hypothesize that endogenous sex steroids are associated with fracture risk independent of race/ethnicity. Design and Setting We performed a nested case-control study within the prospective Women's Health Initiative Observational Study. Incident nonspine fractures were identified in 381 black, 192 Hispanic, 112 Asian, and 46 Native American women over an average of 8.6 years. A random sample of 400 white women who experienced an incident fracture was chosen. One control was selected per case and matched on age, race/ethnicity, and blood draw date. Bioavailable estradiol (BioE2), bioavailable testosterone (BioT), and sex hormone-binding globulin (SHBG) were measured using baseline fasting serum. Conditional logistic regression models calculated the odds ratio (OR) and 95% confidence interval (CI) of fracture across tertiles of hormone. Results In multivariable and race/ethnicity-adjusted models, higher BioE2 (>8.25 pg/mL) and higher BioT (>13.3 ng/dL) were associated with decreased risk of fracture (OR, 0.65; 95% CI, 0.50 to 0.85; P trend = 0.001 and OR, 0.76; 95% CI, 0.60 to 0.96; P trend = 0.02, respectively). The interaction term between race/ethnicity and either BioE2 or BioT was not significant. There was no association between SHBG and fracture risk. In models stratifying by race/ethnicity, higher BioE2 was associated with a lower risk of fracture in both white women (OR, 0.56; 95% CI, 0.36 to 0.87) and black women (OR, 0.61; 95% CI, 0.39 to 0.96). Higher BioT was associated with a significantly lower fracture risk in only black women (OR, 0.65; 95% CI, 0.43 to 1.00), P trend = 0.03. Conclusions Serum BioE2 and BioT are associated with fracture risk in older women irrespective of race/ethnicity and independent of established risk factors for fracture.
Effects of Particle Size on the Attenuated Total Reflection Spectrum of Minerals

This study focuses on particle size effect on monomineralic powders recorded using attenuated total reflection Fourier transform infrared (ATR FT-IR) spectroscopy. Six particle size fractions of quartz, feldspar, calcite, and dolomite were prepared (<2, 2–4, 4–8, 8–16, 16–32, and 32–63 µm). It is found that the width, intensity, and area of bands in the ATR FT-IR spectra of minerals have explicit dependence on the particle size. As particle size increases, the intensity and area of IR bands usually decrease while the width of bands increases. The band positions usually shifted to higher wavenumbers with decreasing particle size. Infrared spectra of minerals are the most intensive in the particle size fraction of 2–4 µm. However, if the particle size is very small (<2 µm), due to the wavelength and penetration depth of the IR light, intensity decreases. Therefore, the quantity of very fine-grained minerals may be underestimated compared to the coarser phases. A nonlinear regression analysis of the data indicated that the average coefficients and indices of the power trend line equation imply a very simplistic relationship between median particle diameter and absorbance at a given wavenumber. It is concluded that when powder samples with substantially different particle size are compared, as in regression analysis for modal predictions using ATR FT-IR, it is also important to report the grain size distribution or surface area of samples. The band area of water (3000–3620 cm–1) is similar in each mineral fraction, except for the particles below 2 µm. It indicates that the finest particles could have disproportionately more water adsorbed on their larger surface area. Thus, these higher wavenumbers of the ATR FT-IR spectra may be more sensitive to this spectral interference if the number of particles below 2 µm is considerable. It is also concluded that at least a proportion of the moisture could be very adhesive to the particles due to the band shift towards lower wavenumbers in the IR range of 3000–3620 cm–1.