Miracle-dz/UniFAR-FTUs huggingface dataset:
Teneligliptin in management of type 2 diabetes mellitus

Teneligliptin is a recently developed oral dipeptidyl peptidase 4 inhibitor indicated for the management of type 2 diabetes mellitus (T2DM) in adults along with diet and exercise. Teneligliptin has been recently available in Japan (Teneria®), Argentina (Teneglucon®), and India (Tenepure; Teneza) at relatively affordable price. This is a positive step toward the management of T2DM in developing countries, where the cost of medicine is out-of-pocket expenditure and is a limiting factor for health care. This review evaluates the efficacy and safety of teneligliptin in the management of T2DM. Teneligliptin has been systematically evaluated in T2DM as monotherapy with diet and exercise and in combination with metformin, glimepiride, pioglitazone, and insulin in short-term (12 weeks) and long-term (52 weeks) studies. These studies have reported a reduction in HbA1c of 0.8%–0.9% within 12 weeks of therapy. Two 52-week studies reported sustained improvement in glycemic control with teneligliptin. Teneligliptin has been found to be well tolerated, and the safety profile is similar to other dipeptidyl peptidase 4 inhibitors. Hypoglycemia and constipation are the main adverse events. Teneligliptin can be administered safely to patients with mild, moderate, or severe renal impairment or end-stage renal disease without dose adjustment. Similarly, it can be used in patients with mild-to-moderate hepatic impairment. Teneligliptin is effective and well tolerated and may have an important role in the management of T2DM.
Recognising severe infection: in hoc signo vinces?

As a junior doctor some years back, more than I can believe now, I remember the anxiety and anticipation I felt as I contacted a family who had taken their toddler home from accident and emergency after reassurance. A blood culture had then rapidly grown a meningococcus. The child was fine after readmission and treatment. It is a singular concern for any doctor dealing with a child presenting acutely with possible infection that they might miss severe bacterial sepsis. Those of us who have worked in paediatric intensive care will all have felt a shudder hearing stories from parents of children with serious illness that was not recognised. We may have looked at our own sick children at 3:00 am and remembered a parent's chilling phrase or description. Last winter H1N1 flu again reminded us just how hard it can be to get a diagnosis right. The failure to recognise or a delay in recognising serious illness was one of the themes identified in ‘Why children die: a pilot study’, after the national confidential enquiry in 2008.1 The need to develop robust systems for identifying the seriously ill child was emphasised. We all understand that clinical experience has an important role to play.2,–,4 Experience, however, takes a long time and a good deal of work to acquire and is …
Image Matching Algorithm based on Feature-point and DAISY Descriptor

Image matching technology is the research foundation of many computer vision problems, and the matching algorithm based on partial features of images is a research focus in this field. In order to overcome the unstable performance of classic SURF algorithm on rotation invariance, an image matching algorithm combined with SURF feature-point and DAISY descriptor is proposed. Based on the feature point detection of SURF algorithm, a principal direction distribution method for DAISY descriptor is put forward, and a novel DAISY descriptor is obtained according to the rotation of the principal direction. In this paper, our proposed algorithm, on the basis of slight increase in running time, improves the image matching capability of the classic SURF algorithm on image rotation. The experimental results show that our proposed algorithm has stronger robustness in a variety of complex cases, such as image blurring, illumination variation, JPEG compression ratio variation, field of view variation, etc. Our proposed algorithm can not only keep the merits of the original SURF algorithm on computation speed, but also improve the matching accuracy on rotation invariance.
Paraventricular thalamic nucleus: Subcortical connections and innervation by serotonin, orexin, and corticotropin‐releasing hormone in macaque monkeys

The present study examines subcortical connections of paraventricular thalamic nucleus (Pa) following small anterograde and retrograde tracer injections in cynomolgus monkeys (Macaca fascicularis). An anterograde tracer injection into the dorsal midline thalamus revealed strong projections to the accumbens nucleus, basal amygdala, lateral septum, and hypothalamus. Retrograde tracer injections into these areas labeled neurons specifically in Pa. Following a retrograde tracer injection into Pa, labeled neurons were found in the hypothalamus, dorsal raphe, and periaqueductal gray. Pa contained a remarkably high density of axons and axonal varicosities immunoreactive for serotonin (5‐HT) and orexin/hypocretin (ORX), as well as a moderate density of fibers immunoreactive for corticotropin‐releasing hormone (CRH). A retrograde tracer injection into Pa combined with immunohistochemistry demonstrated that ORX and 5‐HT axons originate from neurons in the hypothalamus and midbrain. Pa‐projecting neurons were localized in the same nuclei of the hypothalamus, amygdala, and midbrain as CRH neurons, although no double labeling was found. The connections of Pa and its innervation by 5‐HT, ORX, and CRH suggest that it may relay stress signals between the midbrain and hypothalamus with the accumbens nucleus, basal amygdala, and subgenual cortex as part of a circuit that manages stress and possibly stress‐related psychopathologies. J. Comp. Neurol. 512:825–848, 2009. © 2008 Wiley‐Liss, Inc.
A randomised, double-blind study comparing the efficacy and tolerability of controlled-release doxazosin and tamsulosin in the treatment of benign prostatic hyperplasia in Brazil

Brazilian patients with benign prostatic hyperplasia were randomised in a 12‐week, double‐blind, double‐dummy study to receive doxazosin gastrointestinal therapeutic system (GITS) 4 mg q.i. d. (n = 82) or tamsulosin 0.4 q.i. d. (n = 83). Primary endpoints were the absolute and percentage change from baseline in symptoms measured by International Prostate Symptom Score (IPSS). Secondary endpoints included IPSS, quality‐of‐life (QOL) question from the IPSS, and questions 6 and 7 of the Sexual Function Abbreviated Questionnaire (SFAQ) at weeks 4 and 12. Doxazosin GITS and tamsulosin improved IPSS with no significant differences between groups at week 12. During weeks 4–8, tamsulosin‐treated patients demonstrated a slower improvement (p < 0.001) in IPSS than doxazosin GITS‐treated patients. The proportion of satisfied patients was observed earlier with doxazosin GITS (p = 0.006) vs. tamsulosin. At week 12, the proportion of patients with little or no difficulty at ejaculation (Q6 of SFAQ) was higher in the doxazosin GITS group (p = 0.019). Both treatments were well tolerated.
Ozonesonde profiles from the West Pacific Warm Pool

We present a series of ozonesonde profiles measured from Manus Island, Papua New Guinea, during February 2014, with new insights on the calibration of ozonesondes for measurements in the tropical troposphere. The experiment formed a part of a wider airborne campaign involving three aircraft based in Guam, to characterise the atmospheric composition above the tropical West Pacific in unprecedented detail. Thirty-nine ozonesondes were launched between 2 and 25 February of which 34 gave good ozone profiles. Particular attention was paid to evaluating the background current of the ozonesondes, as this can amount to half the measured signal in the tropical tropopause layer (TTL). An unexpected contamination event affected the measurements and required a departure from standard operating procedures for the ozonesondes. The most significant departure was not exposing the sondes to ozone during preparation, which meant that the background current remained stable before launch. Comparison with aircraft measurements allows validation of the measured ozone profiles and confirms that for well-characterized sondes (background current ∼ 50 nA) a constant background current could be assumed throughout the profile, equal to the minimum value measured during preparation just before launch. From this set of 34 ozonesondes, the minimum reproducible ozone concentration measured in the TTL was 12–13 ppbv; no examples of ozone concentrations< 5 ppbv, as reported by other recent papers, were measured. The lowest ozone concentrations coincided with outflow from extensive deep convection to the east of Manus, consistent with uplift of ozone-poor air from the boundary layer. However, these minima were lower than the ozone concentration measured through most of the boundary layer, and were matched only by measurements at the surface in Manus.
Genetic diversity of siderophore-producing bacteria of tobacco rhizosphere

The genetic diversity of siderophore-producing bacteria of tobacco rhizosphere was studied by amplified ribosomal DNA restriction analysis (ARDRA), 16S rRNA sequence homology and phylogenetics analysis methods. Studies demonstrated that 85% of the total 354 isolates produced siderophores in iron limited liquid medium. A total of 28 ARDRA patterns were identified among the 299 siderophore-producing bacterial isolates. The 28 ARDRA patterns represented bacteria of 14 different genera belonging to six bacterial divisions, namely β-, γ-, α-Proteobacteria, Sphingobacteria, Bacilli, and Actinobacteria. Especially, γ-Proteobacteria consisting of Pseudomonas, Enterobacter, Serratia, Pantoea, Erwinia and Stenotrophomonas genus encountered 18 different ARDRA groups. Results also showed a greater siderophore-producing bacterial diversity than previous researches. For example, Sphingobacterium (isolates G-2-21-1 and G-2-27-2), Pseudomonas poae (isolate G-2-1-1), Enterobacter endosymbiont (isolates G-2-10-2 and N-5-10), Delftia acidovorans (isolate G-1-15), and Achromobacter xylosoxidans (isolates N-46-11HH and N-5-20) were reported to be able to produce siderophores under low-iron conditions for the first time. Gram-negative isolates were more frequently encountered, with more than 95% total frequency. For Gram-positive bacteria, the Bacillus and Rhodococcus were the only two genera, with 1.7% total frequency. Furthermore, the Pseudomonas and Enterobacter were dominant in this environment, with 44.5% and 24.7% total frequency, respectively. It was also found that 75 percent of the isolates that had the high percentages of siderophore units (% between 40 and 60) belonged to Pseudomonas. Pseudomonas sp. G-229-21 screened out in this study may have potential to apply to low-iron soil to prevent plant soil-borne fungal pathogen diseases.
Loan Portfolio and Performance of Bank Holding Companies in the US: 2006-2008

The paper examines loan portfolio of bank holding companies in the US during the years 2006-2008 to identify any significant differences in bank lending before and during the financial crisis. The results of the study suggest that for the largest banks there was no significant change in loan portfolio throughout 2006-8. However, for small banks, the share of real estate loans slightly increased in 2008 where as the share of consumer loans declined suggesting some possible substitution of consumer loans by real estate loans. The study also examines the relationship between loan types and overall performance of bank holding companies in order to identify any significant difference in the effect of loan on bank profitability between the years 2006, 2007 and 2008. The empirical evidence suggests that higher aggregate loans were consistently associated with lower bank performance throughout 2006-08 where as evidence for the varying effect of loan portfolio on performance throughout 2006-08 is limited.
Examining the entry of Walmart into South Africa: A stakeholder management perspective

The recent entry of the US multinational Walmart into South Africa has proved to be a source of controversy. Key stakeholders in South Africa objected to the merger and attempted to block it unless certain conditions were met. The aim of this study was to examine the controversy and the conditions surrounding the merger. The research employed a qualitative archival analysis to examine publicly available sources of information with regard to the merger. The findings revealed key stakeholdersâ€™ concerns that Walmartâ€™s entry would lead to an increase in imports which would displace local producers, increase unemployment, marginalise trade unions and lower labour standards unless certain conditions were met. The results also revealed problems relating to the firmâ€™s primary focus on â€œbusinessâ€ while neglecting â€œpublic interestâ€ issues, naively relying on their â€œlocal retailerâ€ to manage key stakeholders, and assuming that their perceived controversial reputation regarding treatment of trade unions and their views about unemployment as well as the controversies surrounding their history of entry into other global markets would not have the major negative impact it did on stakeholders in South Africa.
QoS-aware resource allocation for mobile media services in cloud environment

With the advancement of technology in smartphones and their popularity, users are expecting higher performance and functionality from mobile devices just as powerful non-mobile devices, especially in the context of multimedia applications. However, despite significant advances in handheld devices, there still exists a gap between device capabilities and the requirements of applications. Mobile Cloud Computing emergence has overcome the barriers of the mobile device restrictions. To improve the performance of media services processed in clouds, an efficient resource allocation mechanism is needed. In this paper, we propose a resource allocation scheme in Mobile Cloud Computing based on Learning Automata technique, taking into account three fundamental concerns: total response time of various types of mobile media services, if they are to be executed on cloud; level of uncertainty (i.e. prone to failure measurement); and computational capacity requirement of services. Simulation results demonstrate that the proposed resource allocation scheme can optimally allocate cloud resources to each media service while ensuring minimal QoS requirements of applications.
Perception and Production of Spanish Vowels by English Speakers

Native Spanish speakers and Canadian English learners of Spanish produced the five Spanish vowels in utterance final /sV/ syllables. The syllables were presented in random order to Spanish and English listeners for identification of vowels in terms of Spanish vowel categories. The English listeners also identified the vowels in terms of English vowel categories. Initial analysis of perceptual results was consistent with English listeners identifying Spanish vowels via assimilation to English vowels, and in the case of Spanish /a/ and /u/ via multiple-category assimilation to more than one English vowel. Spanish listeners correctly identified English speakers’ vowels at higher rates than Spanish speakers’ vowels. This is consistent with English speakers basing their Spanish vowel productions on English vowels, resulting in less intra-vowel variation. Spanish listeners’ results were also consistent with part of the vowel space being uncommitted to any Spanish vowel.
High-Performance Work Systems and Organizational Performance: The Mediating Role of Internal Social Structure

This study provides a theoretical framework illustrating how the internal social structure of the organization can mediate the relationship between high-performance work systems (HPWS) and organizational performance. HPWS positively influence the internal social structure by facilitating bridging network ties, generalized norms of reciprocity, shared mental models, role making, and organizational citizenship behavior. Although HPWS are conceptualized as a system of human resource (HR) practices, each category ofHRpractices has a differential relationship with the mediating variables. HPWS lead to (a) financial performance via administrative efficiency and (b) sustainable performance via flexibility arising from the coordination and exploitation of knowledge resources.
Tri-Party Underground Symbiosis between a Weevil, Bacteria and a Desert Plant

Inhabitants of arid ecosystems face severe nitrogen and water limitations. Inventive adaptations by organisms occupying such habitats are essential for survival. This study describes a tri-party symbiotic interaction between a plant (Salsola inermis), a beetle (Conorhynchus pistor), and a bacterium (Klebsiella pneumonia). The weevil survives by living within a mud structure affixed to the plant roots, thus benefiting from increased carbon and water, and refuge from predators and parasites. Active nitrogen-fixing bacteria harbored within the weevil's gut mediate this interaction, by supplying nitrogen to the system, which eventually promotes seed development. We studied the correlation between the weevil's existence and (i) root carbon and nitrogen content, (ii) soil water content and (iii) seed weight. Roots hosting weevils contained more nitrogen, heavier seeds and less carbon. In addition, water content was higher around the roots than in open spaces a short distance from the plant stem. Bacterial studies and nitrogen-fixation analyses, including molecular and chemical assays, indicated atmospheric nitrogen fixation in the larval stage and identified the bacterium. The coexistence of weevil and bacterial behavior coinciding with the plant's life cycle was revealed here by a long period of field observations. Out of over 60,000 known weevils, this is the only report of a weevil living most of its life underground without harming plants. The unique tri-party interaction described herein shows the important ecological role of desert plant roots and provides an example of a sustainable consortium of living organisms coping with the challenging desert environment.
Improvements in Birch's theorem on forms in many variables

We show that a non-singular integral form of degree d is soluble non-trivially over the integers if and only if it is soluble non-trivially over the reals and the p-adic numbers, provided that the form has at least (d-\sqrt{d}/2)2^d variables. This improves on a longstanding result of Birch.
Diagnosis-related deterioration of lung function after extracorporeal membrane oxygenation

The aim of the study was to assess lung function longitudinally after neonatal extracorporeal membrane oxygenation (ECMO), and to identify any effects of diagnosis and perinatal characteristics. 121 neonatal ECMO-treated children (70 with meconium aspiration syndrome, 20 congenital diaphragmatic hernia and 31 with other diagnoses) performed a total of 191 lung function measurements at 5, 8 and/or 12 yrs. We assessed dynamic and static lung volumes, reversibility of airway obstruction and diffusion capacity. Mean SDS forced expiratory volume in 1 s (FEV1) at 5 yrs before and after bronchodilation (-0.51 and 0.07) was significantly higher than at 8 (-0.79 and -0.4; p<0.04) and 12 yrs (-1.10 and -0.52; p<0.003). Mean SDS for all spirometric parameters before and after bronchodilation were significantly lower in the congenital diaphragmatic hernia group compared with the other diagnostic groups (all p≤0.025). A significant volume of trapped air was observed in 86% patients with congenital diaphragmatic hernia, 50% with meconium aspiration syndrome and 58% with other diagnoses. After bronchodilation, mean SDS FEV1 and forced vital capacity were negatively influenced by duration of ventilation (both p<0.001) and duration of ECMO (p=0.003 and p=0.02, respectively). Long-term pulmonary sequelae after neonatal ECMO-treatment mainly occur in congenital diaphragmatic hernia patients and tend to deteriorate over time.
Multiwavelength study of the nuclei of a volume‐limited sample of galaxies – I. X‐ray observations

We discuss ROSAT HRI X-ray observations of 33 very nearby galaxies, sensitive to X-ray sources down to a luminosity of approximately 1038 erg s−1. The galaxies are selected from a complete, volume-limited sample of 46 galaxies with for which we have extensive multiwavelength data. For an almost complete subsample with (29/31 objects) we have HRI images. Contour maps and source lists are presented within the central region of each galaxy, together with nuclear upper limits where no nuclear source was detected. Nuclear X-ray sources are found to be very common, occurring in ∼35 per cent of the sample. Nuclear X-ray luminosity is statistically connected to host galaxy luminosity – there is not a tight correlation, but the probability of a nuclear source being detected increases strongly with galaxy luminosity, and the distribution of nuclear luminosities seems to show an upper envelope that is roughly proportional to galaxy luminosity. While these sources do seem to be a genuinely nuclear phenomenon rather than nuclear examples of the general X-ray source population, it is far from obvious that they are miniature Seyfert nuclei. The more luminous nuclei are very often spatially extended, and H ii region nuclei are detected just as often as LINERs. Finally, we also note the presence of fairly common superluminous X-ray sources in the off-nuclear population – out of 29 galaxies we find nine sources with a luminosity greater than 1039 erg s−1. These show no particular preference for more luminous galaxies. One is already known to be a multiple SNR system, but most have no obvious optical counterpart and their nature remains a mystery.
Multi-level parallelism analysis of face detection on a shared memory multi-core system

Face detection is one of the fundamental technologies for the future smart objects. However, its computation intensive property thwarts the practice of a real-time application on an embedded device. Parallel processing and many-core architecture have become a mainstream to achieve high performance in the future computing systems. The parallelism of an application needs to be exposed before being exploited by the parallel architecture. This paper performs a comprehensive analysis of the parallelism of a face detection algorithm at different algorithmic levels. This paper has demonstrated that each parallelism level has its own potential to enhance performance, but also imposes different limiting factors to the overall performance. Based on the analysis results and design experience, this paper proposes a multi-staged mixed-level parallelization scheme to retain the performance scalability and avoid the limiting factors. With this scheme, we are able to achieve up to 37.5x performance enhancement on a 64-core system.
Analisis Financial Distress Untuk Memprediksi Risiko Kebangkrutan Perusahaan (STUDIKASUS PADA INDUSTRI PERBANKAN DI BEI)

Kebangkrutan diawali dengan adarrya financial distress, dan kebanyakan kasuskebangkrutan bermula dari adanya kesulitan keuangan yang dialami perusahaan.Penelitian ini dilakukan untuk mengetahui kemungkinan terjadinya kebangkrutanperusahaan perbankan berdasarkan analisis financial distress dengan 12 rasiokeuangan antara lain CAR (Capital Adequacy Ratio), KAP (Kualitas AktivaProduktifi, NPL (Non Performing Loan), ROA (Return On Assets), BOPO (BebanOperasional to Pendapatan Operasional), LDR (Loan to Deposit Ratio), NCMCA(Net Call Money to Current Assets), GROWTH (Pertumbuhan), EVA (EconomicValue Added), LM (Leverage Management), COD (Cost Of Debt), dan ROE (ReturnOn Equity). Sampel penelitian terdiri dari 10 bank yang memiliki rata-rata assetsdiatas 20.000. 000 (million Rp) selama tahun 2004-2007. Metode analisis data yangdigunakan untuk mengufi hipotesis penelitian adalah penilaian tingkat kesehatanbank melalui perhitungan rasio keuangan, metode Statistic Deskriptif analisisMultivariate dengan Two-Group Discriminant Analysis, Casewise statistic, danStepwise satatistic. Hasil penelitian menunjukan dengan analisis financial distressdapat diprediksi kemungkinan kebangkrutan dengan ketepatan klasiflkasi sebesar85% dan variabel yang berpengaruh dominan adalah NPL.