Miracle-dz/UniFAR-FTUs huggingface dataset:
The combination of cisplatin and topotecan as a second-line treatment for patients with advanced/recurrent uterine cervix cancer

Abstract We retrospectively reviewed outcomes of treatments with cisplatin and topotecan in patients with previously-treated uterine cervix cancer. We analyzed the medical records of patients with advanced (stage IVB) or recurrent or persistent squamous or non-squamous cell carcinoma of the cervix, who were treated with cisplatin and topotecan as a second-line chemotherapy between January 2000 and December 2015. The patients were treated with a combination of cisplatin (50 mg/m2 for 1 day) and topotecan (0.75 mg/m2 for 3 days) once every 3 weeks. Treatment response, progression-free survival (PFS), and overall survival (OS) were analyzed in all patients and between responder and non-responder groups (responders showed at least a partial response to prior systemic chemotherapy). Thirty-nine patients with a median age of 47 years (range, 32–73 years) were treated with cisplatin and topotecan. The median PFS was 4.6 months (95% confidence interval [CI], 1.2–7.9 months) and the median OS was 14.1 months (95% CI, 10.0–18.2 months). The overall response rate (ORR) was 30.8%, and the disease control rate was 56.4%. The ORR was significantly better in the responder group compared with the non-responder group (50.0% vs 10.5%; P = .008). All patients reported some grade of hematological toxicity. The most frequently encountered toxicity was anemia, with a rate of 59.7% for any grade and 13.2% for grade 3 or 4. The combination of cisplatin and topotecan was effective as second-line chemotherapy in patients with advanced/recurrent uterine cervix cancer.
From Hydration to Strength Properties of Fly Ash Based Mortar

Fly ash (FA) is important alternative or supplement to cement to reduce the environmental impact of concrete industry. However, early age strength development of FA is a concern due to the slower reaction rate of FA compared to cement. This paper examines the early age hydration properties of cement paste containing typical Australian FA and establishes correlations between the degree of hydration and the early-age strength development properties of mortar mixes. All mixes have the same mixture proportion of water to binder (w:b) ratio. FA sourced from different power plants are used for the tests. Cement replacement levels of 0%, 10%, 30% and 40% by mass are considered. The degree of hydration was established from the heat production of the mixes by using isothermal calorimetry. The hydration properties were characterized by hydration curve parameters obtained from curve fitting. The results show that both hydration rate and strength of the binder materials (FA and cement) were reduced with higher replacement levels of FA contributing to a reduced hydration rate at early ages. Linear relationship could be obtained between degree of hydration and strength at early ages for all the fly ash binders.
Observation of pronuclei may not be an absolute indicator for fertilization in rescue intracytoplasmic sperm injection oocytes

This case report describes a successful full-term pregnancy and birth after the transfer of rescue intracytoplasmic sperm injection (ICSI) embryos derived from 1-day-old oocytes. A total of eight oocytes were retrieved and inseminated 3 h after collection. No oocytes were fertilized 16–18 h after insemination. A rescue ICSI was performed on the four metaphase II stage oocytes. At the regular time (16 h after ICSI) of examination for fertilization, there were no distinct two pronuclei (2PN) in the cytoplasm of any oocytes, but the culture of these oocytes led to the development of four two-cell stage embryos 26 h after ICSI. Further culture of these four embryos showed development to a four-cell stage the following day. The transfer of three embryos resulted in a full-term pregnancy with the delivery of a pair of healthy twins. This result suggests that the observation of 2PN at the normal time of fertilization assessment may not appear to be an absolute indicator of fertilization in the case of rescue ICSI.
Safety and Diagnostic Image Quality of Ultravist® in an Unselected Sub-Set of Chinese Patients: Data Analyses from a Previous Post Marketing Surveillance

Background: Iopromide (Ultravist®) has been shown to be a very safe CM agent in previous post-marketing surveillance studies on Western and Asian populations. Our study aimed to analyse data pertaining to the safety, tolerability and diagnostic image quality of Iopromide in an unselected sub-set of the Chinese population. Methods: we analysed data for Chinese ambulatory and in-patients who received Iopromide for an imaging procedure (in accordance with the local package insert and routine clinical practice), as part of an international post-marketing surveillance study. Use of premedication was at the discretion of the attending physician. Patient demographics, clinical history, type of examination, contrast quality and tolerability, including pre-specified adverse drug reactions, were recorded. All statistical analyses were descriptive. Results: case report forms for 20,000 Chinese patients (61.3% men) were analysed, of whom 153 patients (0.77%) had risk factors for idiosyncratic contrast media reactions (at-risk group). Use of premedication, most commonly corticosteroids, was recorded for 5658 patients (28.3%) and 86 at-risk patients (56.2% of the at-risk group), respectively. The mean (±standard deviation) dose of iodine administered was 29 ± 5.5 g. During the physician’s evaluation of image parameters, contrast quality was considered to be “good” (64.7%) or “excellent” (29.3%) in the majority of patients. 571 patients (2.9%) experienced at least one adverse drug reaction [most frequently nausea (0.70%) and dysgeusia (0.62%)], which were typically transient and of mild intensity. Two serious adverse drug reactions were reported [edema (n = 1), decreased blood pressure and dyspnea (n = 1)]. The incidence of adverse drug reactions was increased in the at-risk group versus the overall patient population, and tended to reduce with premedication (mainly corticosteroids). Conclusions: Iopromide was well tolerated and proved to be an efficient contrast agent in a large, non-selected sub-set of Chinese patients undergoing different types of diagnostic imaging procedures.
The projection median as a weighted average

The projection median of a set $P$ of $n$ points in $\mathbb{R}^d$ is a robust geometric generalization of the notion of univariate median to higher dimensions. In its original definition, the projection median is expressed as a normalized integral of the medians of the projections of $P$ onto all lines through the origin. We introduce a new definition in which the projection median is expressed as a weighted mean of $P$, and show the equivalence of the two definitions. In addition to providing a definition whose form is more consistent with those of traditional statistical estimators of location, this new definition for the projection median allows many of its geometric properties to be established more easily, as well as enabling new randomized algorithms that compute approximations of the projection median with increased accuracy and efficiency, reducing computation time from $O(n^{d+\epsilon})$ to $O(mnd)$, where $m$ denotes the number of random projections sampled. Selecting $m \in \Theta(\epsilon^{-2} d^2 \log n)$ or $m \in \Theta(\min ( d + \epsilon^{-2} \log n, \epsilon^{-2} n))$, suffices for our algorithms to return a point within relative distance $\epsilon$ of the true projection median with high probability, resulting in running times $O(d^3 n \log n)$ and $O(\min(d^2 n, d n^2))$ respectively, for any fixed $\epsilon$.
Studies on alterations of clinical and hemato-biochemical parameters before and after treatment in calves naturally infected with theileriosis

Aim: The aim was to determine hemato-biochemical alterations and to determine the better treatment of theileriosis in naturally infected calves. Materials and Methods: A total of 74 Holstein crossbred calves below 6 months of age, of either sex were included for present investigation in Bikaner. Based on the clinical examinations and laboratory results, 20 calves included for hemato-biochemical studies (before and after treatment) and divided into two groups (having 10 calves each). Results: The clinical examination of these calves revealed weakness, ticks infestations, high fever above 104°F, pronounced swelling of prescapular, prefemoral, parotid lymph nodes, loss of elasticity of skin, anemia, lacrimal discharges, pulpy cornea, tachycardia, and dyspnea. There was highly significant decrease (p<0.01) in hemoglobin, total erythrocyte count, packed cell volume and total leukocyte count, serum glucose, total protein, globulin and albumin level and highly significant increase in aspartate aminotransferase and alanine aminotransferase level as compared to healthy control animals in Group I and II. The animals of Group II treated with buparvaquone along with single blood transfusion shows better recovery then animals of Group I treated with bupavaqone and hematinic. Conclusions: Significant changes were found in hemato-biochemical parameters in theileria affected calves before treatment as compare to healthy control calves. Significant improvement was observed in hemato-biochemical parameters in buparvaquone and single blood transfusion treated calves as compare to another group, so it is concluded that buparvaquone and single blood transfusion is better combination for treatment of theileriosis.
Large-Scale Fabrication of RF MOSFETs on Liquid-Exfoliated MoS2

For the first time, thousands of RF MOSFETs were batch-fabricated on liquid-exfoliated Mos2 below 300°C with nearly 100% yield. The large-scale fabrication with high yield allowed the average performance instead of the best performance to be reported. The DC performance of these devices were typical, but the RF performance, enabled by buried gates and on the order of 100 MHz, was reported for the first time for liquid-exfoliated Mos2. To resolve the dilemma of thin vs. thick films, channel recess was used on 20-nm thick films to improve the gate control while keeping the contact resistance lower than that on 10-nm films. These innovations may enable thin-film transistors to operate in the microwave range,
Speech-like vocalizations in infancy: an evaluation of potential risk factors

ABSTRACT This work reports longitudinal evaluation of the speech-like vocal development of infants born at risk due to prematurity or low socio-economic status (SES) and infants not subject to such risk. Twenty infants were preterm (10 of low SES) and 33 were full term (16 of low SES), and all were studied from 0;4 through 1;6. The study provides the indication that at-risk infants are not generally delayed in the ability to produce well-formed speech-like sounds as indicated in taperecorded vocal samples. At the same time, premature infants show a tendency to produce well-formed syllables less consistently than full terms after the point at which parents and laboratory personnel note the onset of the canonical babbling stage (the point after which well-formed syllables are well established in the infant vocal repertoires). Further, even though low SES infants produce well-formed speech-like structures on schedule, they show a reliably lower tendency to vocalize in general, as reflected by fewer utterances per minute in recorded samples.
Investigation of structural, optical and electrical properties of Co3O4 nanoparticles

In the current work, we report the synthesis of Cobalt oxide (Co3O4) NPs (NPs) by co-precipitation method. The structural analysis was confirmed by using X-ray diffractometer (XRD) which shows that the Co3O4 NPs have cubic phase. The average crystallite size and the lattice parameter were calculated for Co3O4 NPs. The functional groups of the as-synthesized sample were examined by Fourier transform infrared spectroscopy (FTIR). The optical band gap of Co3O4 NPs was estimated by using UV diffuse reflectance spectroscopy and the Band gap was evaluated by using Tauc relation. The temperature dependence of dielectric constant and dielectric loss were studied over a range of temperature 50-300 °C. The DC electrical resistivity of Co3O4 NPs shows a semiconducting behaviour and the value of activation energy was calculated by using Arrhenius equation.In the current work, we report the synthesis of Cobalt oxide (Co3O4) NPs (NPs) by co-precipitation method. The structural analysis was confirmed by using X-ray diffractometer (XRD) which shows that the Co3O4 NPs have cubic phase. The average crystallite size and the lattice parameter were calculated for Co3O4 NPs. The functional groups of the as-synthesized sample were examined by Fourier transform infrared spectroscopy (FTIR). The optical band gap of Co3O4 NPs was estimated by using UV diffuse reflectance spectroscopy and the Band gap was evaluated by using Tauc relation. The temperature dependence of dielectric constant and dielectric loss were studied over a range of temperature 50-300 °C. The DC electrical resistivity of Co3O4 NPs shows a semiconducting behaviour and the value of activation energy was calculated by using Arrhenius equation.
Artificial Night Lighting Reduces Firefly (Coleoptera: Lampyridae) Occurrence in Sorocaba, Brazil

Artificial night lighting is gaining attention as a new type of pollution; however, studies of its impacts are scarce. Fireflies provide good models to investigate its effects on nocturnal wildlife, since they depend on their bioluminescence for reproduction. This study investigated the impact of artificial illumination on firefly activity at the new campus of the Federal University of S&atildeo Carlos (Sorocaba, Brazil). The flashing activity of different firefly species, especially Photinus sp1 (82% of all occurrences), was investigated during 3 years, before and after the installation of multi metal vapor spotlights. Quantitative and qualitative analysis, performed in transects at different distances from the artificial light sources, showed significant negative effects on Photinus sp1 occurrence. This study proposes fireflies as potential flagship species and bioindicators for artificial night lighting and for the first time quantifies its effects, providing subsidies for future conservationist legislations regarding photopollution.
Mid-level deep Food Part mining for food image recognition

There has been a growing interest in food image recognition for a wide range of applications. Among existing methods, mid-level image part-based approaches show promising performances due to their suitability for modelling deformable food parts (FPs). However, the achievable accuracy is limited by the FP representations based on low-level features. Benefiting from the capacity to learn powerful features with labelled data, deep learning approaches achieved state-of-the-art performances in several food image recognition problems. Both mid-level-based approaches and deep convolutional neural networks (DCNNs) approaches clearly have their respective advantages, but perhaps most importantly these two approaches can be considered complementary. As such, the authors propose a novel framework to better utilise DCNN features for food images by jointly exploring the advantages of both the mid-level-based approaches and the DCNN approaches. Furthermore, they tackle the challenge of training a DCNN model with the unlabelled mid-level parts data. They accomplish this by designing a clustering-based FP label mining scheme to generate part-level labels from unlabelled data. They test on three benchmark food image datasets, and the numerical results demonstrate that the proposed approach achieves competitive performance when compared with existing food image recognition approaches.
Does Grammatical Number Influence the Semantic Priming Between Number Cues and Words Related to Vertical Space? An Investigation Using Virtual Reality

The GES framework postulates a hierarchical order between grounded, embodied, and situated representations. Against this background, the present study investigated the relation of two effects: (i) a semantic priming between number cues and words with referents up or down in the world according to the number's magnitude which is supposed to be grounded (cf. Lachmair et al., 2014) and (ii) the compatibility between number cues and the grammatical word form of the words according to the number's multitude which is supposed to be embodied (cf. Roettger and Domahs, 2015). In two experiments words referring to objects up or down in the world and spatially neutral words were presented subsequent to the numbers “1” and “9. ” In Experiment 1 words were presented in singular word form and in Experiment 2 in plural word form. For the first time, Virtual Reality was used in such an experimental setup in order to reduce spatial predispositions of participants and to provide a homogeneous experimental environment for replication purposes. According to GES it was expected that the spatial semantic priming should occur in both grammatical word forms. However, the compatibility with grammatical number should only occur for the plural word form due to its markedness. The results of Experiment 1 support the spatial-semantic-priming-hypothesis but not the grammatical-number-hypothesis. The results of Experiment 2 supported only the grammatical-number-hypothesis. It is argued that the grounded spatial effect of Experiment 1 was not affected by grammatical number. However, in Experiment 2 this effect vanished due to an activated embodied reference frame according to grammatical number.
PREDICTING OBESITY IN YOUNG ADULTHOOD FROM CHILDHOOD AND PARENTAL OBESITY

A BSTRACT Background Childhood obesity increases the risk of obesity in adulthood, but how parental obesity affects the chances of a child’s becoming an obese adult is unknown. We investigated the risk of obesity in young adulthood associated with both obesity in childhood and obesity in one or both parents. Methods Height and weight measurements were abstracted from the records of 854 subjects born at a health maintenance organization in Washington State between 1965 and 1971. Their parents’ medical records were also reviewed. Childhood obesity was defined as a body-mass index at or above the 85th percentile for age and sex, and obesity in adulthood as a mean body-mass index at or above 27.8 for men and 27.3 for women. Results In young adulthood (defined as 21 to 29 years of age), 135 subjects (16 percent) were obese. Among those who were obese during childhood, the chance of obesity in adulthood ranged from 8 percent for 1or 2-year-olds without obese parents to 79 percent for 10-to-14-year-olds with at least one obese parent. After adjustment for parental obesity, the odds ratios for obesity in adulthood associated with childhood obesity ranged from 1.3 (95 percent confidence interval, 0.6 to 3.0) for obesity at 1 or 2 years of age to 17.5 (7.7 to 39.5) for obesity at 15 to 17 years of age. After adjustment for the child’s obesity status, the odds ratios for obesity in adulthood associated with having one obese parent ranged from 2.2 (95 percent confidence interval, 1.1 to 4.3) at 15 to 17 years of age to 3.2 (1.8 to 5.7) at 1 or 2 years of age. Conclusions Obese children under three years of age without obese parents are at low risk for obesity in adulthood, but among older children, obesity is an increasingly important predictor of adult obesity, regardless of whether the parents are obese. Parental obesity more than doubles the risk of adult obesity among both obese and nonobese children under 10 years of age. (N Engl J Med 1997;337:869-73.)
Neural Correlates of Swimming Behavior in Melibe leonina

The nudibranch Melibe leonina swims by rhythmically bending from side to side at a frequency of 1 cycle every 2–4 s. The objective of this study was to locate putative swim motoneurons (pSMNs) that drive these lateral flexions and determine if swimming in this species is produced by a swim central pattern generator (sCPG). In the first set of experiments, intracellular recordings were obtained from pSMNs in semi-intact, swimming animals. About 10–14 pSMNs were identified on the dorsal surface of each pedal ganglion and 4–7 on the ventral side. In general, the pSMNs in a given pedal ganglion fired synchronously and caused the animal to flex in that direction, whereas the pSMNs in the opposite pedal ganglion fired in anti-phase. When swimming stopped, so did rhythmic pSMN bursting; when swimming commenced, pSMNs resumed bursting. In the second series of experiments, intracellular recordings were obtained from pSMNs in isolated brains that spontaneously expressed the swim motor program. The pattern of activity recorded from pSMNs in isolated brains was very similar to the bursting pattern obtained from the same pSMNs in semi-intact animals, indicating that the sCPG can produce the swim rhythm in the absence of sensory feedback. Exposing the brain to light or cutting the pedal-pedal connectives inhibited fictive swimming in the isolated brain. The pSMNs do not appear to participate in the sCPG. Rather, they received rhythmic excitatory and inhibitory synaptic input from interneurons that probably comprise the sCPG circuit.
A tripartite survey of hyperparasitic fungi associated with ectoparasitic flies on bats (Mammalia: Chiroptera) in a neotropical cloud forest in Panama

The Darién province in eastern Panama is one of the most unexplored and biodiverse regions in the world. The Chucantí Nature Reserve, in Serranía de Majé, consists of a diverse tropical cloud forest ecosystem. The aim of this research was to explore and study host associations of a tripartite system of bats, ectoparasitic flies on bats (Diptera, Streblidae), and ectoparasitic fungi (Ascomycota, Laboulbeniales) that use bat flies as hosts. We captured bats at Chucantí, screened each bat for presence of bat flies, and screened collected bat flies for presence of Laboulbeniales. We mistnetted for 68 mistnet hours and captured 227 bats representing 17 species. We captured Micronycteris schmidtorum, a species previously unreported in Darién. In addition, we encountered the rarely collected Platyrrhinus dorsalis, representing the westernmost report for this species. Of all captured bats, 148 carried bat flies (65%). The number of sampled bat flies was 437, representing 16 species. One species represents a new country record (Trichobius anducei) and five species represent first reports for Darién (Basilia anceps, Anatrichobius scorzai, Nycterophilia parnelli, T. johnsonae, T. parasiticus). All 74 bat fly species currently reported in Panama are presented in tabulated form. Of all screened bat flies, 30 bore Laboulbeniales fungi (7%). Based on both morphology and large ribosomal subunit (LSU) sequence data, we delimited 7 species of Laboulbeniales: Gloeandromyces nycteribiidarum (newly reported for Panama), G. pageanus, G. streblae, Nycteromyces streblidinus, and 3 undescribed species. Of the 30 infected flies, 21 were Trichobius joblingi. This species was the only host on which we observed double infections of Laboulbeniales.