Miracle-dz/UniFAR-FTUs huggingface dataset:
Size, Value, and Momentum in Polish Equity Returns: Local or International Factors?

Abstract This paper tests the performance of the Capital Asset Pricing Model (CAPM) and the Fama-French three-factor and Carhart four-factor models on the Polish market. We use stock level data from April 2001 to January 2014 and find strong evidence for value and momentum effects, but only weak evidence for size premium. We formed portfolios double-sorted on size and book-to-market ratios, as well as on size and momentum, and we explain their returns with the above-mentioned asset pricing models. The CAPM is rejected and the three-factor and four-factor models perform well for the size and B/M sorted portfolios, but fail to explain returns on the size and momentum sorted portfolios. With the exception of the momentum factor, local Polish factors are not correlated with their European and global counterparts, suggesting market segmentation. Finally, the international value, size and momentum factors perform poorly in explaining cross-sectional variation in stock returns on the Polish market.
Proposal for a [111] magnetization plateau in the spin liquid state of Tb2Ti2O7

Despite a Curie–Weiss temperature θCW∼−14 K, the Tb2Ti2O7 pyrochlore magnetic material lacks long range magnetic order down to at least T*≈50 mK. It has recently been proposed that the low temperature collective paramagnetic or spin liquid regime of this material may be akin to a spin ice state subject to both thermal and quantum fluctuations—a quantum spin ice (QSI) of sorts. Here we explore the effect of a magnetic field B along the [111] direction on the QSI state. To do so, we investigate the magnetic properties of a microscopic model of Tb2Ti2O7 in an independent tetrahedron approximation in a finite field B along [111]. Such a model describes semi-quantitatively the collective paramagnetic regime where nontrivial spin correlations start to develop at the shortest length scale, that is over a single tetrahedron, but where no long range order is yet present. Our results show that a magnetization plateau develops at low temperatures as the system develops B = 0 ferromagnetic spin ice like ‘two-in/two-out’ correlations at the shortest length scale. From these results, we are led to propose that the observation of such a [111] magnetization plateau in Tb2Ti2O7 would provide compelling evidence for a QSI at B = 0 in this material and help guide the development of a theory for the origin of its spin liquid state.
Process-time Optimization of Vacuum Degassing Using a Genetic Alloy Design Approach

This paper demonstrates the use of a new model consisting of a genetic algorithm in combination with thermodynamic calculations and analytical process models to minimize the processing time during a vacuum degassing treatment of liquid steel. The model sets multiple simultaneous targets for final S, N, O, Si and Al levels and uses the total slag mass, the slag composition, the steel composition and the start temperature as optimization variables. The predicted optimal conditions agree well with industrial practice. For those conditions leading to the shortest process time the target compositions for S, N and O are reached almost simultaneously.
Dual Tracking Method for Real Time Object Tracking using Moving Camera

This study presents dual tracking method for real time object tracking using a moving camera. A real time object tracking using self aligning servo mechanism with webcam, dual tracking and effective localization of object is presented. The proposed dual tracking method works in two phases: In first phase tracking is done by joint color texture histogram with mean shift and in second phase tracking is done by servo setup. The proposed dual tracking method enjoys the benefit of double tracking feature, not only tracking but also to find out the coordinates of the tracking object which is of particular interest. The coordinates of a moving object enable us to estimates the real time location of the object which is helpful in surveillance and shooting purposes of suspected person in security area. The tracking of some specific objects in real life is of particular interest. Due to its enhanced automation the proposed dual tracking method can be applied in public security, surveillance, robotics and traffic control etc. The experimental results demonstrate that the proposed dual tracking method improves greatly the tracking area with accuracy and efficiency and also successfully find the coordinates of moving object.
Protective effect of D609 against amyloid‐beta1–42‐induced oxidative modification of neuronal proteins: Redox proteomics study

Oxidative stress has been implicated in the pathophysiology of a number of diseases, including neurodegenerative disorders such as Alzheimer's disease (AD), a neurodegenerative disorder associated with cognitive decline and enhanced oxidative stress. Amyloid‐beta peptide1–42 (Aβ1–42), one of the main component of senile plaques, can induce in vitro and in vivo oxidative damage to neuronal cells through its ability to produce free radicals. The aim of this study was to investigate the protective effect of the xanthate D609 on Aβ1–42‐induced protein oxidation by using a redox proteomics approach. D609 was recently found to be a free radical scavenger and antioxidant. In the present study, rat primary neuronal cells were pretreated with 50 μM of D609, followed by incubation with 10 μM Aβ1–42 for 24 hr. In the cells treated with Aβ1–42 alone, four proteins that were significantly oxidized were identified: glyceraldehyde‐3‐phosphate dehydrogenase, pyruvate kinase, malate dehydrogenase, and 14‐3‐3 zeta. Pretreatment of neuronal cultures with D609 prior to Aβ1–42 protected all the identified oxidized proteins in the present study against Aβ1–42‐mediated protein oxidation. Therefore, D609 may ameliorate the Aβ1–42‐induced oxidative modification. We discuss the implications of these Aβ1–42‐mediated oxidatively modified proteins for AD pathology and for potential therapeutic intervention in this dementing disorder. © 2006 Wiley‐Liss, Inc.
Software Engineering Education in India: Issues and Challenges

Indian software industry has set up huge growth targets for future. These targets would be heavily affected by the software engineering (SE) education scenario in the country. The purpose of this paper is to provide a holistic understanding of SE education issues and challenges specific to Indian context, from both industry and academic perspective. This study is based on our (a) interaction with industry through SE education related projects, surveys and discussions. (B) Observations as an integral part of Indian SE educators' community. There is an urgent need for addressing these deep rooted issues, as the lack of proper SE education may be the single largest factor that may negatively affect the industry. Understanding these issues will help to identify the action items that initiate software engineering educational reforms in the country. We also discuss the essential and minimal set of SE knowledge, skills and dispositions that the Indian industry expects from engineers who will be joining the industry. Indian software industry is a global leader in software application development and maintenance services, but there very few studies on the issues and effects associated with SE education in the Indian context. Though this discussion is limited to India, but we believe that it represents the existing conditions in many developing countries where IT and ITES (IT enabled services) industry is gaining importance.
Pure red cell aplasia induced by epoetin zeta

Pure red cell aplasia (PRCA) may develop in patients with chronic kidney disease receiving erythropoiesis-stimulating agents (ESA). We report on a 72-year-old patient who developed hypo-proliferative anaemia unresponsive to ESA following the administration of epoetin zeta subcutaneously for 7 months. On the basis of severe isolated hypoplasia of the erythroid line in the bone marrow and high-titre neutralizing anti-erythropoietin antibodies (Ab), a diagnosis of Ab-mediated PRCA was made. Epoetin zeta was discontinued and the patient was given steroids. This was associated with anaemia recovery. To our knowledge this is the first PRCA case related to epoetin zeta.
The Graded Change in Connectivity across the Ventromedial Prefrontal Cortex Reveals Distinct Subregions

Abstract The functional heterogeneity of the ventromedial prefrontal cortex (vmPFC) suggests it may include distinct functional subregions. To date these have not been well elucidated. Regions with differentiable connectivity (and as a result likely dissociable functions) may be identified using emergent data-driven approaches. However, prior parcellations of the vmPFC have only considered hard splits between distinct regions, although both hard and graded connectivity changes may exist. Here we determine the full pattern of change in structural and functional connectivity across the vmPFC for the first time and extract core distinct regions. Both structural and functional connectivity varied along a dorsomedial to ventrolateral axis from relatively dorsal medial wall regions to relatively lateral basal orbitofrontal cortex. The pattern of connectivity shifted from default mode network to sensorimotor and multimodal semantic connections. This finding extends the classical distinction between primate medial and orbital regions by demonstrating a similar gradient in humans for the first time. Additionally, core distinct regions in the medial wall and orbitofrontal cortex were identified that may show greater correspondence to functional differences than prior hard parcellations. The possible functional roles of the orbitofrontal cortex and medial wall are discussed.
Month-Timescale Optical Variability in the M87 Jet

A previously inconspicuous knot in the M87 jet has undergone a dramatic outburst and now exceeds the nucleus in optical and X-ray luminosity. Monitoring of M87 with the Hubble Space Telescope and Chandra X-Ray Observatory during 2002-2003, has found month-timescale optical variability in both the nucleus and HST-1, a knot in the jet 0. ″82 from the nucleus. We discuss the behavior of the variability timescales as well as spectral energy distribution of both components. In the nucleus, we see nearly energy-independent variability behavior. Knot HST-1, however, displays weak energy dependence in both X-ray and optical bands but with nearly comparable rise/decay timescales at 220 nm and 0.5 keV. The flaring region of HST-1 appears stationary over 8 months of monitoring. We consider various emission models to explain the variability of both components. The flares we see are similar to those seen in blazars, albeit on longer timescales, and so could, if viewed at smaller angles, explain the extreme variability properties of those objects.
Bone mass and turnover after allogeneic stem cell transplantation

A prospective study of bone loss and turnover after allogeneic bone marrow transplantation; effect of calcium supplementation with or without calcitonin. of bone mass and normalization of bone turnover in long-term survivors of allogeneic bone marrow transplantation.tion of bone loss after allogeneic stem cell transplantation by calcium, vitamin -D, and sex hormone replacement with or without pamidronate. 6 ABSTRACT Allogeneic stem cell transplantation (SCT) is an important form of treatment for many haematological diseases. When acute complications, such as infections and graft-versus-host disease, are treatable, more attention is paid to the long-term complications of the procedure. The experience from solid organ transplantations shows that bone loss, osteoporosis and fractures are important complications of these procedures. Consequently, the present study of patients with SCT was undertaken to answer the following questions: I What is the magnitude and timing of bone loss? II What is the mechanism of bone loss as examined by bone turnover markers and serum osteopro-tegerin and RANKL measurements? III Can the bone status of SCT patients improve spontaneously? IV How and by what mechanism does allogeneic SCT performed in childhood affect peak bone mass in adolescence and young adulthood? V Can bone loss be prevented by calcium, vitamin D, calcitonin, sex steroid replacement therapy or bisphosphonates? Altogether 187 patients with allogeneic SCT participated in the studies; 73 healthy individuals served as controls in biochemical measurements. Bone mineral density (BMD) was measured by dual-energy X-ray absorptiometry (DXA). Bone turnover rate was assessed by measuring the markers of bone formation [bone-specific alkaline phosphatase (B-ALP), type I procollagen amino-(PINP) and carboxyterminal propep-tides (PICP) and osteocalcin (OC)] and resorption [cross-linked carboxyterminal tel-opeptide of type I collagen (ICTP), C-terminal cross-linked telopeptide of type I colla-gen (CTX), aminoterminal telopeptide of type I collagen (NTX) and tartrate-resistant acid phosphatase 5 b (TRACP5b)]. During six months after SCT, BMD of the lumbar spine (LS) and the femoral neck (FN) reduced by 5.8 % and 7.0 %, respectively. During the next six months, the LS BMD slightly recovered but the FN BMD further decreased to 8.0%. Thirty-nine per cent of SCT patients had either osteopenia or osteoporosis at the LS before transplan-tation, and the number increased up to 47 % one year after SCT. At the FN, 25 % of patients had a reduced BMD at baseline and 58 % one year after SCT. The markers of bone formation decreased during the first three months but returned …
A Model of Aggressive Behavior: Early Adversity, Impulsivity, and Response Inhibition

ABSTRACT Exposure to adverse environments during childhood is robustly linked to future aggressive behavior. In this study we tested a model of emotional and neurocognitive mechanisms related to aggressive behavior in the context of childhood adversity. More specifically, we used path analysis to assess the distal contribution of childhood adversity and the more proximal contributions of emotion-related and non-emotion-related forms of impulsivity, and behavioral response inhibition to aggressive behavior. Participants were 180 undergraduates who completed well-validated self-report measures and an emotional version of the Go/No-Go task. The structural equation model was a poor fit for the data (χ2(3) = 23.023, p<. 001; RMR = . 131; CFI = . 682; RMSEA = . 142), though several significant paths emerged. Childhood adversity, emotion-related impulsivity, and behavioral response inhibition displayed direct effects on aggression, collectively accounting for 16.3% of variance. Findings demonstrate the specificity of emotional subtypes of impulsivity in linking childhood adversity and aggression. This study extends work on pathways to aggressive behavior by illustrating the complex relationships of early environmental, cognitive, and emotional mechanisms related to aggression.
Comparison of reduced order lithium-ion battery models for control applications

Lithium-ion batteries are the core of new plug-in hybrid-electrical vehicles (PHEV) as well as considered in many 2nd generation hybrid electric vehicles (HEV). In most cases the lithium-ion battery performances play an important role in the vehicle energy management. As consequence, battery modeling is one of the most important tasks for hybrid and electrical vehicles control. Full order electrochemical models have to be simplified in order to make them compatible with estimation algorithms embedded in a real-time on-board electronic control unit. The battery model simplification has to be carried out accurately in order to achieve maximum computational cost reduction while ensuring the best model performance and reaching an efficient system management. In this paper two different reduced order models, based on the electrochemical laws, are compared both with simulation results and with experimental data collected from a 10 Ah lithium-ion battery. The reduced order models characteristics are analyzed and compared in relation to the specific control objective.
Dysregulated RANK Ligand/RANK Axis in Hyperhomocysteinemic Subjects: Effect of Treatment With B-Vitamins

Background and Purpose— Homocysteine has been linked to increased risk of ischemic stroke and other cardiovascular events. Matrix degradation and inflammation play an important role in these disorders, and we have demonstrated increased levels of matrix-degrading enzymes and inflammatory cytokines in hyperhomocysteinemic individuals. Recent studies suggest that RANK ligand (RANKL) through interaction with its receptor RANK can modulate matrix degradation and inflammation. The present study aimed to examine the role of the RANKL/RANK axis in hyperhomocystinemia. Methods— RANKL/RANK was measured on protein or mRNA level before and after B-vitamin supplementation in hyperhomocysteinemic individuals. We also examined the in vitro effects of soluble RANKL in peripheral blood mononuclear cells from hyperhomocysteinemic individuals. Results— Our main findings were: (1) compared to peripheral blood mononuclear cells from controls, cells from hyperhomocysteinemic individuals had significantly higher gene expression of RANKL and RANK; (2) folic acid treatment for 6 weeks in an open, uncontrolled study significantly reduced gene expression of RANKL/RANK in peripheral blood mononuclear cells from these individuals; (3) compared to placebo, treatment with folic acid, vitamin B12, and vitamin B6 for 3 months in a randomized, double-blind trial significantly lowered serum levels of soluble RANKL in hyperhomocysteinemic individuals; and (4) in vitro, soluble RANKL markedly increased the release of matrix metalloproteinase-9 and inflammatory cytokines from peripheral blood mononuclear cells in hyperhomocysteinemic subjects. Conclusions— Our findings suggest a dysregulated RANKL/RANK axis in hyperhomocysteinemic subjects. Based on their role in atherogenesis, this enhanced expression of RANKL and RANK could contribute to the increased risk of cardiovascular disease in hyperhomocystinemia. Moreover, treatment with B-vitamins may have beneficial implications for plaque stability in these individuals.
Evidence for Sub-Haplogroup H5 of Mitochondrial DNA as a Risk Factor for Late Onset Alzheimer's Disease

Background Alzheimer's Disease (AD) is the most common neurodegenerative disease and the leading cause of dementia among senile subjects. It has been proposed that AD can be caused by defects in mitochondrial oxidative phosphorylation. Given the fundamental contribution of the mitochondrial genome (mtDNA) for the respiratory chain, there have been a number of studies investigating the association between mtDNA inherited variants and multifactorial diseases, however no general consensus has been reached yet on the correlation between mtDNA haplogroups and AD. Methodology/Principal Findings We applied for the first time a high resolution analysis (sequencing of displacement loop and restriction analysis of specific markers in the coding region of mtDNA) to investigate the possible association between mtDNA-inherited sequence variation and AD in 936 AD patients and 776 cognitively assessed normal controls from central and northern Italy. Among over 40 mtDNA sub-haplogroups analysed, we found that sub-haplogroup H5 is a risk factor for AD (OR = 1.85, 95% CI:1.04–3.23) in particular for females (OR = 2.19, 95% CI:1.06–4.51) and independently from the APOE genotype. Multivariate logistic regression revealed an interaction between H5 and age. When the whole sample is considered, the H5a subgroup of molecules, harboring the 4336 transition in the tRNAGln gene, already associated to AD in early studies, was about threefold more represented in AD patients than in controls (2.0% vs 0.8%; p = 0.031), and it might account for the increased frequency of H5 in AD patients (4.2% vs 2.3%). The complete re-sequencing of the 56 mtDNAs belonging to H5 revealed that AD patients showed a trend towards a higher number (p = 0.052) of sporadic mutations in tRNA and rRNA genes when compared with controls. Conclusions Our results indicate that high resolution analysis of inherited mtDNA sequence variation can help in identifying both ancient polymorphisms defining sub-haplogroups and the accumulation of sporadic mutations associated with complex traits such as AD.
Embeddings of Some Weighted Function Spaces on R N ; Entropy and Approximation Numbers | a Survey of Some Recent Results. |

In this survey we summarise recent results concerning compact embeddings of some weighted function spaces of type B s p;q and F s p;q on R n. We study the asymptotic behaviour of their entropy and approximation numbers. We give some motivation how to apply results of this type in spectral theory. This survey provides a uniied approach of recent outcomes (which have mostly been published before) and marks some present`state of the art' in this eld of research.
Addressing the Broadband Demand Gap: Drivers and Public Policies

The debate about the digital divide in the field of Internet use and broadband has, in large part, been generated around statistics of households that own a computer and have purchased a broadband subscription (in other words, service penetration). As a result, the political discussion and public dialogue have focused until now on the need to increase adoption based on wider coverage of telecommunications networks. The underlying premise of this statement is that if the problems that delay infrastructure deployment were addressed, the challenge of the digital divide would be overcome. Without denying that there is some causal relationship between investment and adoption, it is important to note that one of the key variables that explains the digital divide is located on the demand side, rather than on the supply side. The purpose of this paper is to analyze the divide from this perspective in industrialized countries and compare it with a similar phenomenon in Latin America.First, quantitative information is presented to demonstrate the existence of a gap in demand, even in industrialized countries. Based on this, the paper reviews the research conducted in the developed world, identifying common causal variables through statistics from different countries, pointing at the root cause of this shortfall. Having presented the situation in industrialized countries, the Latin American demand gap is then examined, focusing first on its size for those countries for which data are available. Following the same process as that of developed countries, the results of research carried out for Latin American countries are presented with the aim to explain the nature of the demand gap. This diagnosis provides a context for outlining policy recommendations that make it possible to address some of the adoption barriers.
Emergence of Biofilm-Forming Subpopulations upon Exposure of Escherichia coli to Environmental Bacteriophages

ABSTRACT Exposure of Escherichia coli MG1655 to environmental bacteriophages results in rapid selection for phage-tolerant subpopulations displaying increased biofilm formation. Analysis of one phage-tolerant strain revealed large amounts of the DNA-binding Dps protein in the outer membrane protein and production of fimbria-like structures. In dps and fimA mutant derivatives of MG1655, no selection of phage-tolerant bacteria upon exposure to bacteriophages occurred, suggesting a role for Dps and type I pili in bacteriophage tolerance.