Miracle-dz/UniFAR-FTUs huggingface dataset:
Integrating Animated Pedagogical Agent as Motivational Supporter into Interactive System

In modern world, children are interested in interacting with computers in many ways, for e.g. game playing, ELearning, chatting etc. This interest could be effectively exploited to develop their personality by creating interactive systems that adapt to different emotional states and intensities of children interacting with them. Many of the existing games are designed to beat the children rather than encourage them to win. Further, many of these systems do not take neither the emotional state nor the intensity of emotions into consideration. In this paper we present an interactive multi-agent based system that recognizes child’s emotion. A social agent uses cognitive and non-cognitive factors to estimate a child’s intensity of emotions in real time and an autonomous/intelligent agent uses cognitive and non-cognitive factors to estimate a child’s intensity of emotions in real time and an autonomous/intelligent agent uses an adaptation model based on the intensity of child’s emotion to change the game status. An animated pedagogical agent gives motivational help to encourage the adaptation of the system in an interactive manner. Results show that affective gesture recognition model recognizes a child’s emotion with a considerably higher rate of over 82.5% and the social agent (estimate intensity of emotion) has strong relationship with observers’ feedback except in low intensity levels.
Experiential Avoidance and Technological Addictions in Adolescents

Background and aims This study focuses on the use of popular information and communication technologies (ICTs) by adolescents: the Internet, mobile phones, and video games. The relationship of ICT use and experiential avoidance (EA), a construct that has emerged as underlying and transdiagnostic to a wide variety of psychological problems, including behavioral addictions, is examined. EA refers to a self-regulatory strategy involving efforts to control or escape from negative stimuli such as thoughts, feelings, or sensations that generate strong distress. This strategy, which may be adaptive in the short term, is problematic if it becomes an inflexible pattern. Thus, the aim of this study was to explore whether EA patterns were associated with addictive or problematic use of ICT in adolescents. Methods A total of 317 students of the Spanish southeast between 12 and 18 years old were recruited to complete a questionnaire that included questions about general use of each ICTs, an experiential avoidance questionnaire, a brief inventory of the Big Five personality traits, and specific questionnaires on problematic use of the Internet, mobile phones, and video games. Results Correlation analysis and linear regression showed that EA largely explained results regarding the addictive use of the Internet, mobile phones, and video games, but not in the same way. As regards gender, boys showed a more problematic use of video games than girls. Concerning personality factors, conscientiousness was related to all addictive behaviors. Discussion and conclusions We conclude that EA is an important construct that should be considered in future models that attempt to explain addictive behaviors.
Nano-CMOS Circuit and Physical Design

FOREWORD.PREFACE. 1 NANO-CMOS SCALING PROBLEMS AND IMPLICATIONS.1. 1 Design Methodology in the Nano-CMOS Era.1. 2 Innovations Needed to Continue Performance Scaling.1. 3 Overview of Sub-100-nm Scaling Challenges and Subwavelength Optical Lithography.1. 4 Process Control and Reliability.1. 5 Lithographic Issues and Mask Data Explosion.1. 6 New Breed of Circuit and Physical Design Engineers.1. 7 Modeling Challenges.1. 8 Need for Design Methodology Changes.1. 9 Summary.References. PART I: PROCESS TECHNOLOGY AND SUBWAVELENGTH OPTICAL LITHOGRAPHY: PHYSICS, THEORY OF OPERATION, ISSUES, AND SOLUTIONS.2 CMOS DEVICE AND PROCESS TECHNOLOGY.2. 1 Equipment Requirements for Front-End Processing.2. 2 Front-End-Device Problems in CMOS Scaling.2. 3 Back-End-of-Line Technology.References. 3 THEORY AND PRACTICALITIES OF SUBWAVELENGTH OPTICAL LITHOGRAPHY.3. 1 Introduction and Simple Imaging Theory.3. 2 Challenges for the 100-nm Node.3. 3 Resolution Enhancement Techniques: Physics.3. 4 Physical Design Style Impact on RET and OPC Complexity.3. 5 The Road Ahead: Future Lithographic Technologies.References. PART II: PROCESS SCALING IMPACT ON DESIGN 4 MIXED-SIGNAL CIRCUIT DESIGN.4. 1 Introduction.4. 2 Design Considerations.4. 3 Device Modeling.4. 4 Passive Components.4. 5 Design Methodology.4. 6 Low-Voltage Techniques.4. 7 Design Procedures.4. 8 Electrostatic Discharge Protection.4. 9 Noise Isolation.4. 10 Decoupling.4. 11 Power Busing.4. 12 Integration Problems.4. 13 Summary.References. 5 ELECTROSTATIC DISCHARGE PROTECTION DESIGN.5. 1 Introduction.5. 2 ESD Standards and Models.5. 3 ESD Protection Design.5. 4 Low-C ESD Protection Design for High-Speed I/O.5. 5 ESD Protection Design for Mixed-Voltage I/O.5. 6 SCR Devices for ESD Protection.5. 7 Summary.References. 6 INPUT/OUTPUT DESIGN.6. 1 Introduction.6. 2 I/O Standards.6. 3 Signal Transfer.6. 4 ESD Protection.6. 5 I/O Switching Noise.6. 6 Termination.6. 7 Impedance Matching.6. 8 Preemphasis.6. 9 Equalization.6. 10 Conclusion.References. 7 DRAM.7. 1 Introduction.7. 2 DRAM Basics.7. 3 Scaling the Capacitor.7. 4 Scaling the Array Transistor.7. 5 Scaling the Sense Amplifier.7. 6 Summary.References. 8 SIGNAL INTEGRITY PROBLEMS IN ON-CHIP INTERCONNECTS.8. 1 Introduction.8. 2 Interconnect Parasitics Extraction.8. 3 Signal Integrity Analysis.8. 4 Design Solutions for Signal Integrity.8. 5 Summary.References. 9 ULTRALOW POWER CIRCUIT DESIGN.9. 1 Introduction.9. 2 Design-Time Low-Power Techniques.9. 3 Run-Time Low-Power Techniques.9. 4 Technology Innovations for Low-Power Design.9. 5 Perspectives for Future Ultralow-Power Design.References. PART III: IMPACT OF PHYSICAL DESIGN ON MANUFACTURING/YIELD AND PERFORMANCE.10 DESIGN FOR MANUFACTURABILITY.10. 1 Introduction.10. 2 Comparison of Optimal and Suboptimal Layouts.10. 3 Global Route DFM.10. 4 Analog DFM.10. 5 Some Rules of Thumb.10. 6 Summary.References. 11 DESIGN FOR VARIABILITY.11. 1 Impact of Variations on Future Design.11. 2 Strategies to Mitigate Impact Due to Variations.11. 3 Corner Modeling Methodology for Nano-CMOS Processes.11. 4 New Features of the BSIM4 Model.11. 5 Summary.References. INDEX.
Men and Women toward the Top: Backgrounds, Careers, and Potential of Federal Middle Managers

Using a variety of data sources, this article compares the earnings, occupations, educations, mobility, handling of subordinates, interactions with supervisors, job satisfaction, and rates of promotion and turnover of men and women in middle-management positions in the federal civil service. Management of problem employees does not differ significantly between the sexes, but women have more problems with their own supervisors than do men. Overall, women are as satisfied as men with the fairness of their treatment, but the women are much more likely to say they have recently lost a job or job reward due to discrimination or a “buddy system. ”
Differential Occurrence of Interactions and Interaction Domains in Proteins Containing Homopolymeric Amino Acid Repeats

Homopolymeric amino acids repeats (AARs), which are widespread in proteomes, have often been viewed simply as spacers between protein domains, or even as “junk” sequences with no obvious function but with a potential to cause harm upon expansion as in genetic diseases associated with polyglutamine or polyalanine expansions, including Huntington disease and cleidocranial dysplasia. A growing body of evidence indicates however that at least some AARs can form organized, functional protein structures, and can regulate protein function. In particular, certain AARs can mediate protein-protein interactions, either through homotypic AAR-AAR contacts or through heterotypic contacts with other protein domains. It is still unclear however, whether AARs may have a generalized, proteome-wide role in shaping protein-protein interaction networks. Therefore, we have undertaken here a bioinformatics screening of the human proteome and interactome in search of quantitative evidence of such a role. We first identified the sets of proteins that contain repeats of any one of the 20 amino acids, as well as control sets of proteins chosen at random in the proteome. We then analyzed the connectivity between the proteins of the AAR-containing protein sets and we compared it with that observed in the corresponding control networks. We find evidence for different degrees of connectivity in the different AAR-containing protein networks. Indeed, networks of proteins containing polyglutamine, polyglutamate, polyproline, and other AARs show significantly increased levels of connectivity, whereas networks containing polyleucine and other hydrophobic repeats show lower degrees of connectivity. Furthermore, we observed that numerous protein-protein, -nucleic acid, and -lipid interaction domains are significantly enriched in specific AAR protein groups. These findings support the notion of a generalized, combinatorial role of AARs, together with conventional protein interaction domains, in shaping the interaction networks of the human proteome, and define proteome-wide knowledge that may guide the informed biological exploration of the role of AARs in protein interactions.
Improved prognosis of patients presenting with clinical markers of spontaneous reperfusion during acute myocardial infarction

Objective: To describe the clinical features, management, and prognosis of patients presenting with clinical markers of spontaneous reperfusion (SR) during acute myocardial infarction (AMI). Design: Cohort study. Setting: National registry of 26 coronary care units. Patients: 2382 consecutive patients with AMI. Main outcome measures: Patient characteristics, management, and mortality. Results: The incidence of SR was 4% of patients (n = 98) compared with thrombolytic treatment (n = 1163, 49%), primary angioplasty (n = 102, 4%), and non-reperfusion (n = 1019, 43%). SR patients were more likely to develop less or no myocardial damage as indicated by a higher percentage of non-Q wave AMI (58% v 32%, 47%, and 44%, respectively, p < 0.0001), aborted AMI (25% v 9%, 8%, and 12%, p < 0.001), and lower peak creatine kinase (503 v 1384, 1519, and 751 IU, p < 0.0001). SR patients, however, were more likely to develop recurrent ischaemic events (35% v 17%, 12%, and 16%, respectively; p < 0.001) and subsequently were more likely to be referred to coronary angiography (67%), angioplasty (41%), or bypass surgery (16%, p < 0.001). Mortality at 30 days (1% v 8%, 7%, and 13%, respectively, p < 0.0001) and one year (6% v 11%, 12%, and 19%, p < 0.0001) was significantly lower for SR patients than for the other subgroups. By multivariate analysis, SR remained a strong determinant of 30 day survival (odds ratio (OR) 0.16, 95% confidence interval (CI) 0.01 to 0.74). At one year, the association between SR and survival decreased (OR 0.49, 95% CI 0.18 to 1.13). Conclusions: Clinical markers of SR are associated with greater myocardial salvage and favourable prognosis. The vulnerability of SR patients to recurrent ischaemic events suggests that they need close surveillance and may benefit from early intervention.
The long-term impact of a whole school approach of restorative practice: the views of secondary school teachers

ABSTRACT Restorative practice (RP) is a behaviour management method that aims to help students develop conflict resolution and aggression management skills. This study aimed to explore the views of teaching professionals about the adoption of RP, as a whole school approach, over a five year period. Five staff (two females, three males) aged between 30 and 56, who worked within the school pastoral care team participated in individual interviews. A thematic analysis of the data identified four themes: the core of RP, restorative communication, learning opportunity, and the impact in practice. Participants’ views about the core components of RP were consistent with those in the literature, with empathic, non-punitive communication being highlighted as essential. RP was seen as offering an important learning opportunity that shaped positive social relationships for both students and teachers, as well as being of benefit to behaviour and academic attainment.
Chemical Constituents of the Ethyl Acetate Extract of Belamcanda chinensis (L.) DC Roots and Their Antitumor Activities

An activity-directed fractionation and purification process was used to isolate antitumor compounds from the roots of Belamcanda chinensis (L.) DC. The ethyl acetate extract showed greater antitumor activities than the other extracts, consequently leading to the isolation of 18 compounds identified as β-sitosterol (1), dausterol (2), quercetin (3), kampferol (4), shikimic acid (5), gallic acid (6), ursolic acid (7), betulin (8), betulonic acid (9), betulone (10), tectoridin (11), irisflorentin (12), 4′,5,6-trihydroxy-7-methoxyisoflavone (13), tectorigenin (14), irilins A (15), iridin (16), irigenin (17), and iristectongenin A (18). Compounds 3–10, 13, and 15 were isolated from B. chinensis for the first time. Compounds 4 and 7–10 showed potent cytotoxic activities against PC3, MGC-803, Bcap-37, and MCF-7 cell lines. The mechanism of the antitumor action of compound 7 was preliminarily investigated through acridine orange/ethidium bromide (AO/EB) staining, Hoechst 33258 staining, and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay, which indicated the growth inhibition of MGC-803 cells via the induction of tumor cell apoptosis.
Gaussian Mixture Kalman predictive coding of LSFS

Gaussian mixture model (GMM)-based predictive coding of line spectral frequencies (LSFs) has gained wide acceptance. In such coders, each mixture of a GMM can be interpreted as defining a linear predictive transform coder. In this paper we optimize each of these linear predictive transform coders using Kalman predictive coding techniques to present GMM Kalman predictive coding. In particular, we show how suitable modeling of quantization noise leads to an adaptive a-posteriori GMM that defines a signal-adaptive predictive coder that provides superior coding of LSFs in comparison with the baseline GMM predictive coder. Moreover, we show how running the Kalman predictive coders to convergence can be used to design a stationary predictive coding system which again provides superior coding of LSFs but now with no increase in run-time complexity over the baseline.
IPP Watermarking Technique for IP Core Protection on FPL Devices

This paper presents a technique for intellectual property protection (IPP) of systems to be implemented over programmable devices. The aim is to protect the author rights of reusable IP cores by means of a digital signature that uniquely identifies both the original design and the design recipient. The technique relies on a procedure that spreads a digital signature in cells of look-up tables of designs at HDL design level, not increasing the area of the system. The technique includes a procedure for signature extraction requiring minimal modifications to the system. So it is possible to detect the ownership rights without interfering the normal operation of the system. The IPP technique has been implemented on FPL devices, not disrupting the functionality neither significantly degrading the performance.
An Investigation of the Relationship between Test Anxiety, Self Esteem and Academic Performance among Polytechnic Students in Nigeria

The aim of this study was to discover how test anxiety and self esteem affect academic performance. Two hundred and fifty randomly drawn final year National Diploma (NDII) students of the Federal Polytechnic, Ilaro were involved in the study. They were given two questionnaires that took between forty and forty five minutes to complete. The study was carried out in a classroom environment during regular school hours. After collecting information from the students through questionnaires, their comprehensive Grade Point Averages (GPA) in previous year were also collected. This GPA data were then compared to the scores obtained from the questionnaires. This study discovered that overall, low anxiety students had higher GPAs than high anxiety students and that there is a positive relationship between self esteem and academic performance. The implication of the findings were that stakeholders in education should formulate policies that help students to cope with anxiety and also initiate programs that will assist the process of learning and mastering challenges as such would result in higher academic achievement.
NEAR-INFRARED-IMAGING POLARIMETRY TOWARD SERPENS SOUTH: REVEALING THE IMPORTANCE OF THE MAGNETIC FIELD

The Serpens South embedded cluster, which is located in the constricted part of a long, filamentary, infrared dark cloud, is believed to be in a very early stage of cluster formation. We present results of near-infrared (JHKs) polarization observations of the filamentary cloud. Our polarization measurements of near-infrared point sources indicate a well-ordered global magnetic field that is perpendicular to the main filament, implying that the magnetic field is likely to have controlled the formation of the main filament. On the other hand, the sub-filaments, which converge on the central part of the cluster, tend to run along the magnetic field. The global magnetic field appears to be curved in the southern part of the main filament. Such morphology is consistent with the idea that the global magnetic field is distorted by gravitational contraction along the main filament toward the northern part, which contains larger mass. Applying the Chandrasekhar–Fermi method, the magnetic field strength is roughly estimated to be a few ×100 μG, suggesting that the filamentary cloud is close to magnetically critical.
A Novel Luciferase Assay For Sensitively Monitoring Myocilin Variants in Cell Culture

Purpose Primary open angle glaucoma–associated mutations in myocilin (MYOC) cause protein “nonsecretion,” rendering secreted MYOC difficult to detect using conventional techniques. This study focused on developing and using an assay that can quickly and easily detect mutant MYOC secretion. Methods We fused Gaussia luciferase (eGLuc2) to MYOC variants and expressed the constructs in HEK-293T and NTM-5 cells. Secreted and intracellular levels of MYOC eGLuc2 variants were evaluated by Western blotting and compared to untagged and FLAG-tagged MYOC constructs. Secreted and soluble intracellular MYOC eGLuc2 were measured by a GLuc assay. The secretion of nine additional MYOC mutants was assayed in conditioned media from transfected cells to test the applicability of the assay for monitoring other MYOC variants. Results Myocilin eGLuc2 behaved similarly to untagged and FLAG-tagged MYOC with respect to secretion, soluble intracellular levels, and in response to drug treatment. The GLuc assay could sensitively detect Y437H MYOC secretion 30 minutes after media change. Gaussia luciferase fused variants followed anticipated trends; nonpathogenic variants (D208E, G244V) were secreted at wild-type (WT) levels, whereas predicted disease-causing variants (C245Y, G246R, E300K, Y437H, I477N) demonstrated substantial secretion defects. Secretion defects caused by the C245Y, G246R, and Y437H mutations were partially rescued by permissive growth temperature. Interestingly, however, this increase in secretion was independent of newly synthesized protein. Conclusions Fusion of eGLuc2 to MYOC does not significantly change the behavior of MYOC. This newly developed MYOC reporter system can be used to study engineered MYOC variants and potentially to identify modulators of MYOC secretion and function.
The Implementation of INA-CBGs (Indonesia Case-Based Groups) System and Strategic Response in Institutional Theory Perspective (Case Research in RSUD Dr. Saiful Anwar Malang)

This research aimed to understand the implementation of INA-CBGs system and organization response in the institutional perspective at RSUD Dr. Saiful Anwar (RSSA). To achieve these objectives, a descriptive qualitative method was used with case study as a strategy. The implementationof INA-CBGs system was analyzed using the institutional forces that exist in the institutional theory of Dimaggio& Powell (1983), and analysis of an organization's response wasbased onstrategic responses ofinstitutional forces by Oliver (1991). The results showed that coercive pressures in the implementation of the INA-CBGs system derived from government regulations.Source normative pressure came from the education and professional standards. Source mimetic pressures came from competition with other hospitals andthe uncertainty of the health industry environment. The strategic response in facingcoercive pressure wasgiving a passive approval and performsomestrategic innovation. While the normative pressurewas responded by training and a more selective recruitment process. Last response related to mimetic pressurewasby imitating theexisting practice from other hospitals.
S-Nitrosylated proteins in pea (Pisum sativum L.) leaf peroxisomes: changes under abiotic stress

Peroxisomes, single-membrane-bounded organelles with essentially oxidative metabolism, are key in plant responses to abiotic and biotic stresses. Recently, the presence of nitric oxide (NO) described in peroxisomes opened the possibility of new cellular functions, as NO regulates diverse biological processes by directly modifying proteins. However, this mechanism has not yet been analysed in peroxisomes. This study assessed the presence of S-nitrosylation in pea-leaf peroxisomes, purified S-nitrosylated peroxisome proteins by immunoprecipitation, and identified the purified proteins by two different mass-spectrometry techniques (matrix-assisted laser desorption/ionization tandem time-of-flight and two-dimensional nano-liquid chromatography coupled to ion-trap tandem mass spectrometry). Six peroxisomal proteins were identified as putative targets of S-nitrosylation involved in photorespiration, β-oxidation, and reactive oxygen species detoxification. The activity of three of these proteins (catalase, glycolate oxidase, and malate dehydrogenase) is inhibited by NO donors. NO metabolism/S-nitrosylation and peroxisomes were analysed under two different types of abiotic stress, i.e. cadmium and 2,4-dichlorophenoxy acetic acid (2,4-D). Both types of stress reduced NO production in pea plants, and an increase in S-nitrosylation was observed in pea extracts under 2,4-D treatment while no total changes were observed in peroxisomes. However, the S-nitrosylation levels of catalase and glycolate oxidase changed under cadmium and 2,4-D treatments, suggesting that this post-translational modification could be involved in the regulation of H2O2 level under abiotic stress.
Applying SVD on Generalized Item-based Filtering

In this paper we examine the use of a matrix factorization technique called Singular Value Decomposition (SVD) along with demographic information in Item -Based Collaborative Filtering. After a brief introduction to SVD and to some of its previous applications in Recommender Systems, we proceed with the presentation of two distinct but related algorithms. The first algorithm uses SVD in order to reduce the dimension of the active item's neighborhood. The second algorithm initially enhances Item -based Filtering with demographic information and then applies SVD at various points of the filtering procedure. The presentations of both algorithms include a detailed step-by-step description and a series of experiments. In both cases the results show that a reduction in the dimension of the item neighborhood via SVD, either by itself or combined with the usage of relevant demographic information, is promising, since it does not only tackle some of the recorded problems of Recommender Systems, but also assists in increasing the accuracy of systems employing it.