Miracle-dz/UniFAR-FTUs huggingface dataset:
Functional Architecture for Disparity in Macaque Inferior Temporal Cortex and Its Relationship to the Architecture for Faces, Color, Scenes, and Visual Field

Binocular disparity is a powerful depth cue for object perception. The computations for object vision culminate in inferior temporal cortex (IT), but the functional organization for disparity in IT is unknown. Here we addressed this question by measuring fMRI responses in alert monkeys to stimuli that appeared in front of (near), behind (far), or at the fixation plane. We discovered three regions that showed preferential responses for near and far stimuli, relative to zero-disparity stimuli at the fixation plane. These “near/far” disparity-biased regions were located within dorsal IT, as predicted by microelectrode studies, and on the posterior inferotemporal gyrus. In a second analysis, we instead compared responses to near stimuli with responses to far stimuli and discovered a separate network of “near” disparity-biased regions that extended along the crest of the superior temporal sulcus. We also measured in the same animals fMRI responses to faces, scenes, color, and checkerboard annuli at different visual field eccentricities. Disparity-biased regions defined in either analysis did not show a color bias, suggesting that disparity and color contribute to different computations within IT. Scene-biased regions responded preferentially to near and far stimuli (compared with stimuli without disparity) and had a peripheral visual field bias, whereas face patches had a marked near bias and a central visual field bias. These results support the idea that IT is organized by a coarse eccentricity map, and show that disparity likely contributes to computations associated with both central (face processing) and peripheral (scene processing) visual field biases, but likely does not contribute much to computations within IT that are implicated in processing color.
Reducing Overconfidence in the Interval Judgments of Experts

Elicitation of expert opinion is important for risk analysis when only limited data are available. Expert opinion is often elicited in the form of subjective confidence intervals; however, these are prone to substantial overconfidence. We investigated the influence of elicitation question format, in particular the number of steps in the elicitation procedure. In a 3‐point elicitation procedure, an expert is asked for a lower limit, upper limit, and best guess, the two limits creating an interval of some assigned confidence level (e.g., 80%). In our 4‐step interval elicitation procedure, experts were also asked for a realistic lower limit, upper limit, and best guess, but no confidence level was assigned; the fourth step was to rate their anticipated confidence in the interval produced. In our three studies, experts made interval predictions of rates of infectious diseases (Study 1, n = 21 and Study 2, n = 24: epidemiologists and public health experts), or marine invertebrate populations (Study 3, n = 34: ecologists and biologists). We combined the results from our studies using meta‐analysis, which found average overconfidence of 11.9%, 95% CI [3.5, 20.3] (a hit rate of 68.1% for 80% intervals)—a substantial decrease in overconfidence compared with previous studies. Studies 2 and 3 suggest that the 4‐step procedure is more likely to reduce overconfidence than the 3‐point procedure (Cohen's d = 0.61, [0.04, 1.18]).
Replication of human cytomegalovirus in human peripheral blood T cells

The replication of human cytomegalovirus (HCMV) strain AD169 was studied in human peripheral blood granulocytes, monocytes-macrophages, B lymphocytes, and T lymphocytes. Progeny virus was produced in some T-cell cultures stimulated in the allogeneic mixed lymphocyte reaction and was regularly obtained when stimulated T cells were grown in the presence of interleukin 2. Replication of HCMV in these cultures was documented by increases in titer, expression of early and late antigen as assessed by indirect immunofluorescence and Western blot, and viral DNA synthesis as determined by dot-blot assays. Approximately 0.05% of cells in virus-producing cultures formed infectious centers, indicating that only a subset of cells takes part in active virus replication. In double-immunofluorescence experiments this subset was found to consist primarily of the T3+ and T8+ phenotype. By infection of preparatively separated T4+ and T8+ T lymphocytes, however, it could be shown that both T-cell subsets were susceptible to HCMV infection as indicated by increases in titer and by DNA kinetics. We conclude from these data that the T lymphocyte might be a target for HCMV in vitro, which is in accordance with in vivo findings in HCMV-infected patients.
Developmental maturation of innate immune cell function correlates with susceptibility to central nervous system autoimmunity

MS is an inflammatory CNS disorder, which typically occurs in early adulthood and rarely in children. Here we tested whether functional maturation of innate immune cells may determine susceptibility to CNS autoimmune disease in EAE. Two‐week‐old mice were resistant to active EAE, which causes fulminant paralysis in adult mice; this resistance was associated with an impaired development of Th1 and Th17 cells. Resistant, young mice had higher frequencies of myeloid‐derived suppressor cells and plasma‐cytoid DCs. Furthermore, myeloid APCs and B cells from young mice expressed lower levels of MHC class II and CD40, produced decreased amounts of proinflammatory cytokines, and released enhanced levels of anti‐inflammatory IL‐10. When used as APCs, splenocytes from 2‐week‐old mice failed to differentiate naive T cells into Th1 and Th17 cells irrespective of the T‐cell donor's age, and promoted development of Treg cells and Th2 cells instead. Adoptive transfer of adult APCs restored the ability of 2‐week‐old mice to generate encephalitogenic T cells and develop EAE. Collectively, these findings indicate that the innate immune compartment functionally matures during development, which may be a prerequisite for development of T‐cell‐mediated CNS autoimmune disease.
Adversarial Manipulation of Deep Representations

We show that the representation of an image in a deep neural network (DNN) can be manipulated to mimic those of other natural images, with only minor, imperceptible perturbations to the original image. Previous methods for generating adversarial images focused on image perturbations designed to produce erroneous class labels, while we concentrate on the internal layers of DNN representations. In this way our new class of adversarial images differs qualitatively from others. While the adversary is perceptually similar to one image, its internal representation appears remarkably similar to a different image, one from a different class, bearing little if any apparent similarity to the input; they appear generic and consistent with the space of natural images. This phenomenon raises questions about DNN representations, as well as the properties of natural images themselves.
Differences in attitudes towards medication between population groups in the Durban Metropolitan Area of South Africa

Objectives Personal factors, especially attitude, have been implicated in the utilization of health care services, and in access to medical treatment. There is little information on the attitudes of the general public in South Africa towards medications and whether attitudes differ across population groups or among the different users of the health care system. This study aimed to determine the general attitude of a local population to medications, self‐care orientation and health professional contact, and whether differences existed between age groups, gender and race groups.
Condensation and Growth of Kirkendall Voids in Intermetallic Compounds

A model for the simulation of Kirkendall voiding in metallic materials is presented based on vacancy diffusion, elastic-plastic and rate-dependent deformation of the material. Starting with a phenomenological explanation of the Kirkendall effect we briefly discuss the consequences on the reliability of microelectronic components. Then, a constitutive model for void nucleation and growth is introduced, which can be used to predict the temporal development of voids in solder joints during thermal cycling. We present numerical studies and discuss the potential of the results for the failure analysis of joining connections.
Comparative effects of dietary wheat bran and its morphological components (aleurone and pericarp-seed coat) on volatile fatty acid concentrations in the rat

1. Adult male rats were fed on diets containing 100 g dietary fibre/kg either as α-cellulose or wheat bran or the pericarp-seed coat or aleurone layers prepared from that bran by sequential milling and air elutriation and electrostatic separation. 2. After 10 d, concentrations of total volatile fatty acids (VFA) in caecal fluid were significantly different between groups and fell in the order: aleurone > wheat bran > pericarp-seed coat > cellulose. This ranking probably reflected the ease of fermentation of fibre polysaccharides by colonic bacteria which also resulted in a considerably higher faecal bacterial mass in the aleurone group. 3. Because of the differences in the volume of caecal digesta, the mass of caecal VFA was considerably the highest in the aleurone group, intermediate with wheat bran and equally low in the pericarp-seed coat and cellulose groups. 4. The diet based on aleurone gave a relatively higher proportion of propionate but with both pericarp-seed coat and wheat bran the contribution of butyrate was raised. 5. VFA concentrations in hepatic portal venous plasma were proportional to caecal concentrations with very high (> 3 mM) values being recorded in the aleurone group. 6. The findings are discussed in relation to the apparent susceptibility of the morphological components of wheat bran to fermentation by large bowel bacteria.
The Role of Neuronal Plasticity in Dystonia

Introduction Herman Oppenheim first coined the term “dystonia” in 1911 to describe a generalised form of the condition with childhood onset, which he called “dystonia musculorum deformans”. In more recent years, dystonia is now recognised as a spectrum of neurological movement disorders characterised by patterned and sustained muscle contractions, resulting in abnormal postures and involuntary twisting movements. In epidemiological studies, it is estimated that the prevalence of early-onset primary torsion dystonia is as high as 50 per million. In the UK alone, it is estimated over 70,000 people are affected by the condition. However, despite the prevalence of this debilitating disorder, the mechanisms underlying dystonia are poorly understood.
Iron deficiency in Helicobacter pylori infected patients in Baghdad

Objectives: Recent studies have suggested an association of Helicobacter pylori and iron deficiency (ID). Materials and methods: To examine an association between H.pylori infection and ID, blood sampling and a data collection survey were performed in 78 H.pylori infected patients and 22 healthy subjects as control. Serum ferritin and iron were measured by ELISA and direct enzymatic method techniques respectively. Results: The result showed that 24 of the patients (30.7%) have serum ferritin and iron concentrations below the normal range indicating iron deficiency, with no significantly difference between women and men. ID was more pronounced in patients with stomach ulcer (58.3%) than those without stomach ulcer (41.7%) respectively. Conclusions: The conclusion was that H.pylori infection might have a role in iron deficiency and subsequently iron de ficiency anemia. J Microbiol Infect Dis 2011; 1(3):114-117
Derivative moments in stationary homogeneous shear turbulence

A statistically stationary and nearly homogeneous turbulent shear flow is established by an additional volume forcing in combination with stress-free boundary conditions in the shear direction. Both turbulent energy and enstrophy are stationary to a much better approximation than in previous simulations that use remeshing. The temporal fluctuations decrease with increasing Reynolds number. Energy spectra and shear-stress cospectra show that local isotropy is satisfactorily obeyed at the level of second-order moments. However, derivative moments of high order up to n = 7 yield increasing moments for n [ges ] 4 for the spanwise vorticity and the transverse derivative of the streamwise velocity in the range of Taylor Reynolds numbers 59 [les ] Rλ [les ] 99. These findings, which are in apparent violation of local isotropy, agree with recent measurements.
Constraints on Antarctic Ice Sheet configuration during and following the Last Glacial Maximum and its episodic contribution to sea-level rise

Abstract Marine geological studies provide a record of diachronous expansion and retreat of the Antarctic Peninsula Ice Sheet, West Antarctic Ice Sheet and East Antarctic Ice Sheet during the past c. 30 000 cal yr BP. Retreat of these ice sheets and Antarctica’s contribution to sea-level rise was largely complete by the early Holocene. Estimates of ice sheet thickness, based on maximum grounding depths, range from 640 to 1640 m on the inner continental shelf. Grounding depths on the outer continental shelf equate to minimum thicknesses of 410–950 m. Geomorphic features indicate that retreat from the continental shelf was mostly step-wise around the continent, a result of the different factors that control ice sheet behaviour and the degree to which these factors vary regionally. Thus, the nature of post-LGM (Last Glacial Maximum) sea-level rise was episodic and believed to have been punctuated by rapid pulses triggered by individual ice stream collapse. Most of these pulses would have been of sub-metre magnitudes and below the resolution of existing sea-level curves, but they would have had significant impact on coastal evolution, especially along low-gradient coasts.
Study of the synergistic anti-inflammatory activity of Solanum xanthocarpum Schrad and Wendl and Cassia fistula Linn

Introduction: Nonsteroidal and steroidal drugs are generally used as a part of drug therapy in inflammation. However, these drugs have severe side-effects like nausea and vomiting. Therefore, there is a need to identify anti-inflammatory compounds that will be effective with a better safety profile. Solanum xanthocarpum Schrad and Wendl and Cassia fistula Linn has many therapeutic uses mentioned in Ayurveda and therefore we aimed to study its anti-inflammatory activity both alone and in combination. Materials and Methods: The water extract of dried fruits of Solanum xanthocarpum Schrad and Wendl and dried pulp of Cassia fistula Linn was prepared. The anti-inflammatory activity of these extracts was investigated using the carragenan-induced paw edema model in rats individually and in two different combinations. ED50 of both the extracts singly and in combination were calculated by dose-response curves, and this information was then plotted on the isobologram. The interaction index of the extracts was also investigated to determine whether both the extracts in combination show synergistic or antagonistic or additive effects. Results: It was observed that extracts of dried fruits of Solanum xanthocarpum showed more anti-inflammatory activity than dried fruits of Cassia fistula Linn. Both the extracts showed maximum anti-inflammatory activity at 500 mg/kg dose. Among the different dose combinations of both the extracts, the 1:1 combination at the 500 mg/kg dose showed maximum percentage inhibition of 75%, which was comparable with the positive control, diclofenac sodium, which showed 81% inhibition. Conclusion: As revealed by the isobolograms, both the combinations fell below the additivity line, which indicates synergistic interactions between Solanum xanthocarpum and Cassia fistula extracts. Interaction indices of both combinations were observed to be <1, which re-demonstrated the synergistic effects of the combination.
Executive Function Impairments in High IQ Adults With ADHD

Objectives: To demonstrate that high IQ adults diagnosed with ADHD suffer from executive function (EF) impairments that: a) can be identified with a combination of standardized measures and self-report data; and b) occur more commonly in this group than in the general population. Method: 157 ADHD adults with IQ ≥ 120 were assessed with 8 normed measures of EF— 3 index scores from standardized tests of memory and cognitive abilities, and 5 subscales of a normed self-report measure of EF impairments in daily life. Results: 73% of subjects were significantly impaired on ≥ 5 of these 8 EF markers. On all 8 measures, incidence of these impairments was significantly greater than in the general population. Conclusion: High IQ adults with ADHD tend to suffer EF impairments that can be assessed with these measures; incidence of such impairments in this group is significantly higher than in the general population. (J. of Att. Dis. 2009; 13(2) 161-167)
Development of a low-speed multi-pole synchronous machine with a field winding on the stator side

This paper proposes a new type of multi-pole synchronous machine in which 2pa-pole armature and 2pf-pole field windings are centrally wound around individual stator teeth. The proposed machine operates as a (2pa+2pf)-pole synchronous machine by providing a magnetic coupling between the armature and field windings through a 2pr-pole reluctance rotor. A 4-kVA, (32+48)-pole prototype machine was designed and built to validate the principle of this structure. Basic characteristics of the prototype machine were simulated using finite element analysis (FEA) and were supported by experiments.
Mode of Information Delivery Does Not Effect Anesthesia Trainee Performance During Simulated Perioperative Pediatric Critical Events: A Trial of Paper Versus Electronic Cognitive Aids

Introduction Cognitive aids (CAs), including emergency manuals and checklists, have been recommended as a means to address the failure of healthcare providers to adhere to evidence-based standards of treatment during crisis situations. Unfortunately, users of CAs still commit errors, omit critical steps, fail to achieve perfect adherence to guidelines, and frequently choose to not use CA during both simulated and real crisis events. We sought to evaluate whether the mode in which a CA presents information (ie, paper vs. electronic) affects clinician performance during simulated critical events. Methods In a prospective, randomized, controlled trial, anesthesia trainees managed simulated events under 1 of the following 3 conditions: (1) from memory alone (control), (2) with a paper CA, or (3) with an electronic version of the same CA. Management of the events was assessed using scenario-specific checklists. Mixed-effect regression models were used for analysis of overall checklist score and for elapsed time. Results One hundred thirty-nine simulated events were observed and rated. Approximately, 1 of 3 trainees assigned to use a CA (electronic 29%, paper 36%) chose not to use it during the scenario. Compared with the control group (52%), the overall score was 6% higher in the paper CA group and 8% higher (95% confidence interval, 0.914.5; P = 0.03) in the electronic CA group. The difference between paper and electronic CA was not significant. There was a wide range in time to first use of the CA, but the time to task completion was not affected by CA use, nor did the time to CA use impact CA effectiveness as measured by performance. Conclusions The format (paper or electronic) of the CA did not affect the impact of the CA on clinician performance in this study. Clinician compliance with the use of the CA was unaffected by format, suggesting that other factors may determine whether clinicians choose to use a CA or not. Time to use of the CA did not affect clinical performance, suggesting that it may not be when CAs are used but how they are used that determines their impact. The current study highlights the importance of not just familiarizing clinicians with the content of CA but also training clinicians in when and how to use an emergency CA.
Structural heterogeneity of the various forms of apomyoglobin; Implications for protein folding

Temperature‐induced denaturation transitions of different structural forms of apomyoglobin were studied monitoring intrinsic tryptophan fluorescence. It was found that the tryptophans are effectively screened from solvent both in native and acid forms throughout most of the temperature range tested. Thus, the tryptophans' surroundings do not show a considerable change in structure where major protein conformational transitions have been found in apomyoglobin using other techniques. At high temperatures and under strong destabilizing conditions, the tryptophans' fluorescence parameters show sigmoidal thermal denaturation. These results, combined with previous studies, show that the structure of this protein is heterogeneous, including native‐like (tightly packed) and molten globule‐like substructures that exhibit conformation (denaturation) transitions under different conditions of pH and temperature (and denaturants). The results suggest that the folding of this protein proceeds via two “nucleation” events whereby native‐like contacts are formed. One of these events, which involves AGH “core” formation, appears to occur very early in the folding process, even before significant hydrophobic collapse in the rest of the protein molecule. From the current studies and other results, a rather detailed picture of the folding of myoglobin is presented, on the level of specific structures and their thermo‐dynamical properties as well as formation kinetics.
Effects of prostate cancer screening on health-related quality of life: Results of the Finnish arm of the European randomized screening trial (ERSPC)

Abstract Background. As prostate cancer (PC) mortality reduction results are not unequivocal, a special emphasis has to be put on other aspects of the prostate-specific antigen (PSA) screening, including effects on quality of life. In the present study we describe the short-term effects of various phases of PC screening on health-related quality of life (HRQL). Material and methods. The study participants were randomized into the screening arm within the Finnish component of the European Randomized Study on Screening for Prostate Cancer (ERSPC). The RAND 36-Item Health Survey on HRQL and questionnaires on sociodemographic and behavioral factors were delivered to participants at various phases of the first screening round: 1) 500 participants at invitation; 2) 500 after screening; 3) 500 after obtaining the PSA result; 4) to 300 participants after undergoing digital rectal examination (DRE) (but prior to being informed of its result); and 5) approximately 300 after prostate biopsy. At each stage, a new sample of participants was recruited. Results. Response rates were 59% at invitation, 77% after PSA blood test, 54% after PSA result and 69% after DRE. The men recruited at each stage were comparable in respect to socioeconomic variables. The HRQL scores in RAND-36 subscales showed little variation in the different phases of the screening process. Compared with the previous phase, the social function score was slightly lower after obtaining the PSA result than after blood test, the emotional role score lower after DRE than after PSA result and the pain-related score lower after DRE than after TRUS and biopsy. The screening participants were comparable to the general population as their HRQL scores were similar to an age-stratified general Finnish male population. Conclusion. Short-term HRQL effects of prostate cancer screening appear minor and transient.