Miracle-dz/UniFAR-FTUs huggingface dataset:
Comparison of synthetic surfactants and biosurfactants in enhancing biodegradation of polycyclic aromatic hydrocarbons

Polycyclic aromatic hydrocarbon (PAH) contamination of the environment represents a serious threat to the health of humans and ecosystems. Given the human health effects of PAHs, effective and cost‐competitive remediation technologies are required. Bioremediation has shown promise as a potentially effective and low‐cost treatment option, but concerns about the slow process rate and bioavailability limitations have hampered more widespread use of this technology. An option to enhance the bioavailability of PAHs is to add surfactants directly to soil in situ or ex situ in bioreactors. Surfactants increase the apparent solubility and desorption rate of the PAH to the aqueous phase. However, the results with some synthetic surfactants have shown that surfactant addition can actually inhibit PAH biodegradation via toxic interactions, stimulation of surfactant degraders, or sequestration of PAHs into surfactant micelles. Biosurfactants have been shown to have many of the positive effects of synthetic surfactants but without the drawbacks. They are biodegradable and nontoxic, and many biosurfactants do not produce true micelles, thus facilitating direct transfer of the surfactant‐associated PAH to bacteria. The results with biosurfactants to date are promising, but further research to elucidate surfactant–PAH interactions in aqueous environments is needed to lead to predictive, mechanistic models of biosurfactant‐enhanced PAH bioavailability and thus better bioremediation design.
Polymorphism of TLR5 rs5744174 is associated with disease progression in Chinese patients with chronic HBV infection

Toll‐like receptors (TLRs) play a crucial role in innate and adaptive immunity, protecting the host from viral pathogens. Studies have implicated that TLR5 is associated with various diseases such as autoimmune and inflammation related diseases. However, little is known about the relationship between TLR5 and hepatitis B virus (HBV) infection. We studied the effect of TLR5 gene polymorphisms on susceptibility to and disease progression of chronic hepatitis B (CHB) infection in Chinese. Blood samples were taken from 636 patients with CHB, HBV‐related liver cirrhosis (LC) or hepatocellular carcinoma (HCC) and 273 controls. Polymorphisms of TLR5 (1775A>G rs2072493 and 1846T>C rs5744174) were analyzed by PCR‐based sequencing. No difference in genotypic and allelic frequencies of TLR5 rs2072493 and rs5744174 was observed between patients and controls. Significant difference was found in frequency of TLR5 rs5744174 TT genotype between men with CHB and LC (p = 0.035). Frequency of TT genotype of TLR5 rs5744174 in patients positive for HBeAg was increased from 53.2% in patients with CHB to 74.1% in those with HCC (p = 0.024). Our results indicate that in Chinese genetic variation of TLR5 may be not a determinant of susceptibility to HBV‐related diseases but may play a role in development of HBV‐related severe liver diseases.
Numerical and experimental studies of heat and flow characteristics in a laminar pipe flow of nanofluid

ABSTRACT Thermal performance of energy systems can be improved by adding metal or metal-oxide nanoparticles to a base fluid, thereby increasing heat-transfer efficiency. Laminar pipe flow of a Cu–water nanofluid was studied using discrete phase model numerical simulation and experimental methods. The forces including thermophoretic and Brownian forces were considered to solve the particles governing equation. A two-step method was employed in the preparation of the nanofluid. The influences of Reynolds number, fluid temperature, and particle volume fraction on the flow pressure drop and convective heat-transfer coefficient of the nanofluid have been studied. The results demonstrated that adding nanoparticles to a base fluid significantly enhanced convective heat transfer in a pipe and increased energy loss. The pressure drop increased with increasing Reynolds number. A critical nanoparticle volume fraction existed, beyond which the pressure drop changed from increasing to decreasing with increasing nanoparticle volume fraction. This is attributed to competition between slip of particles on the pipe wall and the effect of a drag force on the particles. The deposition efficiency of nanoparticle changing with the particle size and volume fraction also has been illustrated.
Endoscopic Cytology for the Diagnosis of Chronic Enteritis and Intestinal Lymphoma in Dogs

Although cytology is a rapid diagnostic procedure in dogs, the cytologic criteria of endoscopic biopsies for chronic enteritis and intestinal lymphoma are not well defined. An immediate diagnosis using cytology would benefit patients by enabling prompt initiation of therapy. The objective of this study was to investigate the correlation between the results of endoscopic cytology and histopathology. In this study, 167 dogs with clinical signs of chronic gastrointestinal disease were included. On the basis of histopathology, the following diagnoses were determined: lymphocytic-plasmacytic enteritis in 93 dogs; eosinophilic enteritis in 5 dogs; small cell intestinal lymphoma in 45 dogs; and large cell intestinal lymphoma in 24 dogs. Two clinical pathologists retrospectively evaluated the endoscopic cytology of squash-smear preparations. The cytologic diagnoses of inflammation, small cell lymphoma, and large cell lymphoma were based on the severity of lymphocyte infiltration, the size of infiltrated lymphocytes, and eosinophil/mast cell infiltration. The clinical severity score was significantly increased along with the degree of lymphocyte infiltration evaluated by cytology. The cytologic diagnosis was in complete agreement with the histopathologic diagnosis in 136 of 167 (81.4%) cases. For the differentiation between enteritis and lymphoma, endoscopic cytology had a sensitivity of 98.6%, a specificity of 73.5%, a positive predictive value of 72.3%, and a negative predictive value of 98.6%. The log-rank test and Cox regression analysis showed that the results of cytology predicted the prognosis. These results suggest that endoscopic cytology is a useful technique to aid diagnosis of intestinal inflammation and lymphoma in dogs.
Postsynaptic BDNF signalling regulates long‐term potentiation at thalamo‐amygdala afferents

Non‐technical summary Long‐term potentiation (LTP) in the lateral amygdala (LA) is a widely accepted cellular correlate of fear learning. In the present study we analysed the involvement of the neurotrophin brain‐derived neurotrophic factor (BDNF) in amygdala LTP by stimulating selectively thalamic or cortical sensory inputs into the LA. In heterozygous BDNF knockout mice we observed that LTP in the cortico‐amygdala pathway remained intact, whereas LTP in the thalamo‐amygdala pathway was abolished. Likewise, acute interference with BDNF/TrkB signalling in wild‐type mice by application of a BDNF scavenger (TrkB‐IgG) led to inhibition of LTP in this pathway. In addition, postsynaptic inhibition of TrkB receptors, which mediate BDNF effects, blocked LTP in the thalamic pathway. Thus, our data demonstrate for the first time a crucial role for postsynaptic BDNF signalling in mediating LTP selectively in the thalamo‐amygdala pathway in the LA.
A gene network model accounting for development and evolution of mammalian teeth

Generation of morphological diversity remains a challenge for evolutionary biologists because it is unclear how an ultimately finite number of genes involved in initial pattern formation integrates with morphogenesis. Ideally, models used to search for the simplest developmental principles on how genes produce form should account for both developmental process and evolutionary change. Here we present a model reproducing the morphology of mammalian teeth by integrating experimental data on gene interactions and growth into a morphodynamic mechanism in which developing morphology has a causal role in patterning. The model predicts the course of tooth-shape development in different mammalian species and also reproduces key transitions in evolution. Furthermore, we reproduce the known expression patterns of several genes involved in tooth development and their dynamics over developmental time. Large morphological effects frequently can be achieved by small changes, according to this model, and similar morphologies can be produced by different changes. This finding may be consistent with why predicting the morphological outcomes of molecular experiments is challenging. Nevertheless, models incorporating morphology and gene activity show promise for linking genotypes to phenotypes.
The Aicardi Syndrome in a 47, XXY Male

Hopkins, I. J., Humphrey, I. , Keith, C. G. , Susman, M. , Webb, G. C. and Turner, E. K. (1979). Aust. Paediatr. J., 278–280. the Aicardi syndrome in a 47, XXY male. The Aicardi syndrome is reported for the first time in a male child. His chromosomal analysis revealed a 47, XXY karyotype. This finding supports the suggestion that this condition is due to a newly mutated X‐chromosomal dominant gene. The existence of a 47, XXY chromosomal constitution in this male allows heterozygous expressions of the gene as in the female.
The Role of HIV Infection in Neurologic Injury

The central nervous system (CNS) is a very challenging HIV-1 sanctuary, in which HIV-1 replication is established early on during acute infection and can persist despite potent antiretroviral treatments. HIV-1 infected macrophages play a pivotal role acting as vehicles for HIV-1 to spread into the brain, and can be the major contributor of an early compartmentalization. HIV-1 infection in CNS may lead to a broad spectrum of neurological syndromes, such as dementia, mild neurocognitive disorders, and asymptomatic impairment. These clinical manifestations are caused by the release of neurotoxins from infected cells (mainly macrophages), and also by several HIV-1 proteins, able to activate cell-signaling involved in the control of cellular survival and apoptosis. This review is aimed at highlighting the virological aspects associated with the onset of neurocognitive disorders and at addressing the novel therapeutic approaches to stop HIV-1 replication in this critical sanctuary.
Prospective Evaluation of Waist Circumference and Visceral Adipose Tissue in Patients with Chronic Kidney Disease

Background: Waist circumference (WC), a simple anthropometric measure, is associated with visceral adipose tissue (VAT) in cross-sectional studies, and thus has been used as a surrogate marker for VAT. However, associations between changes over time in WC and VAT have not been studied in chronic kidney disease (CKD) patients. Methods: This prospective study included 87 nondialysis-dependent CKD patients (54 males, 56.2 ± 10.4 years, BMI 27.3 ± 5.1, GFR 35.9 ± 14.6 ml/min/1.73 m2). VAT area was measured by computed tomography (CT) and WC was measured at the umbilicus level at baseline and after 12 months. Results: Changes in WC correlated significantly but weakly with changes in VAT (r = 0.26, p = 0.016), likely due to a substantially smaller change in WC compared to changes in VAT. This was also reflected by a kappa coefficient of 0.26, i.e. indicative of poor agreement between WC and CT measurements in regards to quantification of changes in VAT. Likewise, the receiver operating characteristic curve analysis identified WC as poor predictor of changes in VAT (area under the curve = 0.62). Conclusion: Anthropometric measurement of WC is poorly correlated with changes in VAT measured by CT in nondialysis-dependent CKD patients. Therefore, caution should be taken when using WC as a surrogate marker of VAT changes in this population.
Diagnostic Measurements for Power Transformers

With the increasing age of the primary equipment of the electrical grids there exists also an increasing need to know its internal condition. For this purpose, off- and online diagnostic methods and systems for power transformers have been developed in recent years. Online monitoring is used continuously during operation and offers possibilities to record the relevant stresses which can affect the lifetime. The evaluation of these data offers the possibility of detecting oncoming faults early. In comparison to this, offline methods require disconnecting the transformer from the electrical grid and are used during planned inspections or when the transformer is already failure suspicious. This contribution presents the status and current trends of different diagnostic techniques of power transformers. It provides significant tutorial elements, backed up by case studies, results and some analysis. The broadness and improvements of the presented diagnostic techniques show that the power transformer is not anymore a black box that does not allow a view into its internal condition. Reliable and accurate condition assessment is possible leading to more efficient maintenance strategies.
Melatonin induces nitric oxide and the potential mechanisms relate to innate immunity against bacterial pathogen infection in Arabidopsis

Melatonin (N‐acetyl‐5‐methoxytryptamine) is a naturally occurring small molecule, serving as important secondary messenger in the response of plants to various biotic and abiotic stresses. However, the interactions between melatonin and other important molecules in the plant stress response, especially in plant immunity, are largely unknown. In this study, we found that both melatonin and nitric oxide (NO) levels in Arabidopsis leaves were significantly induced by bacterial pathogen (Pst DC3000) infection. The elevated NO production was caused by melatonin as melatonin application enhanced endogenous NO level with great efficacy. Moreover, both melatonin and NO conferred improved disease resistance against Pseudomonas syringe pv. tomato (Pst) DC3000 infection in Arabidopsis. NO scavenger significantly suppressed the rise of NO which was induced by exogenous application of melatonin. As a result, the beneficial effects of melatonin on the expression of salicylic acid (SA)‐related genes and disease resistance against bacterial pathogen infection were jeopardized by use of a NO scavenger. Consistently, melatonin application significantly lost its effect on the innate immunity against P. syringe pv. tomato (Pst) DC3000 infection in NO‐deficient mutants of Arabidopsis. The results indicate that melatonin‐induced NO production is responsible for innate immunity response of Arabidopsis against Pst DC3000 infection.
Diarrhea, Pneumonia, and Infectious Disease Mortality in Children Aged 5 to 14 Years in India

Background Little is known about the causes of death in children in India after age five years. The objective of this study is to provide the first ever direct national and sub-national estimates of infectious disease mortality in Indian children aged 5 to 14 years. Methods A verbal autopsy based assessment of 3 855 deaths is children aged 5 to 14 years from a nationally representative survey of deaths occurring in 2001–03 in 1·1 million homes in India. Results Infectious diseases accounted for 58% of all deaths among children aged 5 to 14 years. About 18% of deaths were due to diarrheal diseases, 10% due to pneumonia, 8% due to central nervous system infections, 4% due to measles, and 12% due to other infectious diseases. Nationally, in 2005 about 59 000 and 34 000 children aged 5 to 14 years died from diarrheal diseases and pneumonia, corresponding to mortality of 24·1 and 13·9 per 100 000 respectively. Mortality was nearly 50% higher in girls than in boys for both diarrheal diseases and pneumonia. Conclusions Approximately 60% of all deaths in this age group are due to infectious diseases and nearly half of these deaths are due to diarrheal diseases and pneumonia. Mortality in this age group from infectious diseases, and diarrhea in particular, is much higher than previously estimated.
Information Asymmetry, Information Precision, and the Cost of Capital

The consequences of information differences across investors in capital markets are still much debated. This paper examines the relation between information differences across investors and the cost of capital, and makes three points. First, in models of perfect competition, information differences across investors affect a firm's cost of capital through investors' average information precision, and not information asymmetry per se. Second, the average precision effect of information that is heterogeneously distributed across investors is unlikely to diversify away when there exist many firms whose cash flows covary. Thus, better disclosure can reduce a firm's cost of capital. Third, the precision effect does not give rise to a separate information-risk factor. These points are important to empirical research in accounting and finance, as well as to regulators who debate future disclosure requirements and the consequences of prior requirements such as Regulation Fair Disclosure.
The effects of continuous and pulsed exposures of suspended clay on the survival, growth, and reproduction of Daphnia magna

Suspended sediments are a natural component of aquatic ecosystems, but anthropogenic activity such as land development can result in significant increases, especially after rain events. Continuous exposures of suspended clay and silt have been shown to affect growth and reproduction of Cladocera, leading to a decrease in population growth rate. The mechanism of clay toxicity in these filter‐feeding organisms is clogging of the gut tract, resulting in decreased food uptake and assimilation. When placed in clean water, daphnids can purge clay from their gut and recover. In many surface waters, aquatic organisms experience episodic exposures of high concentrations of suspended solids driven by rain events. However, little is known about the consequences of pulsed exposures on individuals and populations. The objective of the present study was to characterize the effects of continuous and pulsed exposures of natural and defined clays on survival, growth, and reproduction of Daphnia magna. Two defined clays, montmorillonite and kaolinite, as well as clay isolated from the Piedmont region of South Carolina, USA, were used. Continuous exposures of clays elicited a dose dependent decrease in survival. Toxicity varied depending on clay source with montmorillonite > natural clay > kaolinite. Pulsed exposures caused a decrease in survival in a 24 h exposure of 734 mg/L kaolinite. Exposure to 73.9 mg/L also caused an increase in the time to gravidity, although there was not a corresponding decrease in neonate production over 21 d. No significant effects resulted from 12 h exposures even at 730 mg/L, almost 10 times the 24‐h reproductive effects concentration. This suggests that exposure duration impacted toxicity more than exposure concentration in these pulsed exposures. Environ. Toxicol. Chem. 2010;29:168–175. © 2009 SETAC
Controversies in cardiovascular medicine Glycaemic control in acute coronary syndromes : prognostic value and therapeutic options

Type 2 diabetes and acute coronary syndromes (ACS) are widely interconnected. Individuals with type 2 diabetes are more likely than non-diabetic subjects to experience silent or manifest episodes of myocardial ischaemia as the first presentation of coronary artery disease. Insulin resistance, inflammation, microvascular disease, and a tendency to thrombosis are common in these patients. Intensive blood glucose control with intravenous insulin infusion has been demonstrated to significantly reduce morbidity and mortality in critically ill hyperglycaemic patients admitted to an intensive care unit (ICU). Direct glucose toxicity likely plays a crucial role in explaining the clinical benefits of intensive insulin therapy in such critical patients. However, the difficult implementation of nurse-driven protocols for insulin infusion able to lead to rapid and effective blood glucose control without significant episodes of hypoglycaemia has led to poor implementations of insulin infusion protocols in coronary care units, and cardiologists now to consider alternative drugs for this purpose. New intravenous or oral agents include the incretin glucagon-like peptide 1 (GLP1), its analogues, and dipeptidyl peptidase-4 inhibitors, which potentiate the activity of GLP1 and thus enhance glucose-dependent insulin secretion. Improved glycaemic control with protective effects on myocardial and vascular tissues, with lesser side effects and a better therapeutic compliance, may represent an important therapeutic potential for this class of drugs in acutely ill patients in general and patients with ACS in particular. Such drugs should be known by practicing cardiologists for their possible use in ICUs in the years to come.
Sex-related differences in clothing-microclimate and subjective perceptions while wearing two outdoor jackets during submaximal exercise in a cool environment

Abstract This study aimed to identify sex-related differences in clothing-microclimate and subjective perceptions while wearing two outdoor jackets in a setting that is representative for outdoor sports at a leisure level. Ten male and 10 female subjects were testing a thin one-layer jacket and a wind- and waterproof three-layer membrane jacket in a climatic chamber (12 °C, 40% relative humidity) during rest, exercise and recovery. Relative humidity, temperature and sweat residues in the clothing system, perceptions of comfort and physiological parameters were measured. For females, relative humidity, sweat residues and loss of body mass were significantly lower without significantly influencing perceptions of comfort. It can be concluded that sex has a strong effect on clothing-microclimate in outdoor jackets with drier microclimate for females. Furthermore, our findings suggest that females are more sensitive to humidity within the clothing system and that they cool easier, especially in periods of rest.
Effects of in vitro digestion and storage on the phenolic content and antioxidant capacity of a red grape pomace

Abstract Red grape pomace (RGP) is a major winery by-product with interesting applications due to its high phenolic content and antioxidant capacity. Effects of in vitro gastrointestinal digestion and storage on the phenolic content and antioxidant capacity of RGP were studied. RGP polyphenols were stable under stomach-mimicking conditions and more sensitive to small intestine conditions, reducing anthocyanins and flavonols. After 3- and 6-month storage, at either 4 or 25 °C, there were no changes in the total phenolic and condensed tannin content, or antioxidant capacity (evaluated by ABTS, FRAP, ORAC assays); however, after 9 months these parameters decreased. Contrarily, chromatic b* values were higher, thus the samples had more intense red color, which may be related to the increased condensed tannin content. Storage time or temperature induced no changes in microbiological load. RGP preserves high antioxidant capacity after storage and in vitro digestion and thus presents potential as a functional ingredient or nutraceutical. Graphical Abstract
Argument Mining: Extracting Arguments from Online Dialogue

Online forums are now one of the primary venues for public dialogue on current social and political issues. The related corpora are often huge, covering any topic imaginable. Our aim is to use these dialogue corpora to automatically discover the semantic aspects of arguments that conversants are making across multiple dialogues on a topic. We frame this goal as consisting of two tasks: argument extraction and argument facet similarity. We focus here on the argument extraction task, and show that we can train regressors to predict the quality of extracted arguments with RRSE values as low as . 73 for some topics. A secondary goal is to develop regressors that are topic independent: we report results of cross-domain training and domain-adaptation with RRSE values for several topics as low as . 72, when trained on topic independent features.