Miracle-dz/UniFAR-FTUs huggingface dataset:
New excavations at the late Pleistocene site of Chinchihuapi I, Chile

Abstract This paper presents new excavation data on the Chinchihuapi I (CH-I) locality within the Monte Verde site complex, located along Chinchihuapi Creek in the cool, temperate Valdivian rain forest of south-central Chile. The 2017 and 2018 archaeological excavations carried out in this open-air locality reveal further that CH-I is an intermittently occupied site dating from the Early Holocene (~10,000 cal yr BP) to the late Pleistocene (at least ~14,500 cal yr BP) and probably earlier. A new series of radiocarbon dates refines the chronology of human use of the site during this period. In this paper, we describe the archaeological and stratigraphic contexts of the recent excavations and analyze the recovered artifact assemblages. A fragmented Monte Verde II point type on an exotic quartz newly recovered from excavations at CH-I indicates that this biface design existed in at least two areas of the wider site complex ~14,500 cal yr BP. In addition, associated with the early Holocene component at CH-I are later Paijan-like points recovered with lithic tools and debris and other materials. We discuss the geographic distribution of diagnostic artifacts from the site and their probable relationship to other early sites in South America.
Women's Experience of Spirituality Within End-Stage Renal Disease and Hemodialysis

The purpose of this descriptive, phenomenological qualitative study is to describe women's lived experiences of spirituality within end-stage renal disease (ESRD) and hemodialysis. The purposive volunteer sample of 16 women regularly attended two outpatient dialysis centers in a large Midwestern city. Audiotaped, transcribed interviews were analyzed using Colaizzi's method. These women affirmed that spirituality was extremely important in living with their illness and necessary treatment regime. Four major clusters of themes pertaining to the women's spiritual experience within their illness emerged: acceptance, understanding, fortification, and emotion modulation. Findings show that spirituality is of great importance in living with ESRD while receiving hemodialysis and suggest that spirituality may be a significant consideration in nursing and interdisciplinary health care. These findings may be used to improve holistic nursing practice and education in related areas.
Detailed lithospheric structure of an arc-continent collision beneath Taiwan revealed by joint inversion of seismological and gravity data

The largest compilation of seismological and gravimetry data are combined in a sequential inversion to shed light on unresolved crustal structures in Northern Taiwan and Southernmost Ryukyu area. Our density and seismic velocity models reveal a NW–SE trending Transfer Zone (TZ) between 23.25°N and 24°N. This primary TZ delimits major changes in the Eurasian Plate (EP) slab geometry and dynamics, as well as first order crustal structure variations. North of this TZ, the EP slab is breaking off from north to south as a result of (1) the extreme EP bending favouring plastic deformation, (2) the stretching of the plate caused by the downward pull of the oceanic part of the slab versus the buoyancy of continental part of the plate still deforming in the Taiwan orogen and (3) the indentation of the EP slab by the western slab edge of the Philippine Sea Plate (PSP). The change of EP slab dip angle is clearly observed in the density profiles. The subvertical northernmost tip of EP slab allows asthenospheric upwelling through slab tear and subsequent invasion of the region beneath the Longitudinal Valley. This process is migrating southward up to the TZ, which marks the transition to a different rheological behaviour. The combination of deep arc-continent collision, clockwise asthenospheric toroidal flow and westward propagation of the southern Okinawa rift results in a 100° clockwise rotation of the northernmost tip of the Central Range. The eastward extrusion of this crustal block (∼90 km in diameter) overlays and deflects the PSP slab. The indentation of the EP by the PSP (Luzon Arc) thus results in complex lithospheric accommodation processes and structures.
Toward Answering Time-Related Questions from Adverse Event Reports Using Ontology-Based Approaches

Identifying the time patterns from medical device adverse event reports can help clinical researchers or medical devices manufacturers to understand cause of events and predict future events. Ontologybased approaches can provide a reliable and effective system for representing both events and temporal relations, annotating the useful information from narratives, and querying and reasoning over the data. This paper discuss our vision on such a system, as well as challenges we encountered during our preliminary studies.
DEAGGREGATION OF eIF4E INDUCED BY mRNA 5′ CAP BINDING

All eukaryotic mRNAs contain a 5′ terminal cap structure, which consists of 7-methylguanosine linked by a 5′-5′ triphosphate bridge to the first transcribed nucleoside (m7GpppN). Specific recognition of the cap by the eukaryotic initiation factor eIF4E plays a key role in regulation of translation initiation as a rate-limiting step. Using dynamic light scattering (DLS), the apo-form of murine eIF4E (33–217) was shown to aggregate. After addition of m7GTP, progressive deaggregation with the time of incubation in the presence of the cap analogue has been observed.
The Dynamic Relationship between Volatility , Volume and Open Interest in CSI 300 Futures Market

This paper investigates the dynamic relationship between volatility, volume and open interest in CSI 300 futures market using asymmetric GARCH model, Granger causality test, variance decomposition and impulse response function based on 1-min data. ARMA-EGARCH model is employed and find that both contemporaneous and lagged volume is positively related to volatility, and current open interest has positive effect on volatility while lagged open interest has negative effect. Furthermore, volume is positively related to volatility and open interest is negatively linked to volatility when take (lagged) volume and (lagged) open interest into account simultaneously. The Granger causality test indicates that there is unidirectional Granger causality from return to open interest, whereas there is bidirectional Granger causality between open interest (return) and volume. Variance decomposition and impulse response function reveal that most variance of return, volume or open interest is triggered by itself. These results imply that volume and open interest are complementary in information dissemination, while volume measures the trade activity and open interest indicates market depth. Key-Words: Index futures, open interest, volatility, EGARCH, VAR, Granger causality test, high-frequency data, time series forecasting
Evaluation of heavy metal accumulation in talinum triangulare grown around Municipal solid waste dumpsites in Nigeria

An evaluation of the accumulation of heavy metals (Cd, Cu, Fe, Ni, Pb and Zn) in Talinum triangulare plant around two municipal solid waste dumpsites in Gombe, Nigeria was carried out using Atomic Absorption Spectrophotometer. The average soil concentrations of the metals in the two dumpsites were in the order Fe>Zn>Pb>Cu>Ni>Cd while the order in Talinum triangulare was Fe>Zn>Cu>Pb>Ni>Cd. The result of soil enrichment factor implicated anthropogenic activities rather than lithogenic inputs as the sources of these heavy metals. The order of mobility (translocation) of the metals from root to shoot tissues is Cd>Pb>Fe>Ni>Zn>Cu while metal bioaccumulation trends in the plant are Cd>Fe>Cu>Zn>Pb>Ni for Bamuza dumpsite (DSS1) and Cd>Cu>Fe>Zn>Ni>Pb for BCGA dumpsite (DSS2). Thus in the two dumpsites, Talinum triangulare exhibited greatest bioaccumulation ability for Cd and least for Ni and Pb. With the exception of Cd, the roots accumulated the metals more than the shoots. The high accumulation of Cd in the shoot system is an indication of the metal’s ability to be readily translocated to plant tops after absorption by the roots. Pearson bivariate correlation indicated significant positive correlations between Cd and Cu (p<0.05); Cu and Zn (p<0.01); Fe and Ni (p<0.05) in the whole plant. Although this study did not implicate Talinum triangulare as a hyperaccumulator plant with regard to the metals studied (Cd, Cu, Fe, Ni, Pb and Zn), its high bioaccumulation of Cd in the shoot tissues is an indication that it may be risky to consume Talinum triangulare grown on dumpsites owing to the toxicity of the metal to humans.
Heterotrimeric Go protein links Wnt-Frizzled signaling with ankyrins to regulate the neuronal microtubule cytoskeleton

Drosophila neuromuscular junctions (NMJs) represent a powerful model system with which to study glutamatergic synapse formation and remodeling. Several proteins have been implicated in these processes, including components of canonical Wingless (Drosophila Wnt1) signaling and the giant isoforms of the membrane-cytoskeleton linker Ankyrin 2, but possible interconnections and cooperation between these proteins were unknown. Here, we demonstrate that the heterotrimeric G protein Go functions as a transducer of Wingless-Frizzled 2 signaling in the synapse. We identify Ankyrin 2 as a target of Go signaling required for NMJ formation. Moreover, the Go-ankyrin interaction is conserved in the mammalian neurite outgrowth pathway. Without ankyrins, a major switch in the Go-induced neuronal cytoskeleton program is observed, from microtubule-dependent neurite outgrowth to actin-dependent lamellopodial induction. These findings describe a novel mechanism regulating the microtubule cytoskeleton in the nervous system. Our work in Drosophila and mammalian cells suggests that this mechanism might be generally applicable in nervous system development and function.
Induction of high-affinity IgE receptor on lung dendritic cells during viral infection leads to mucous cell metaplasia

Respiratory viral infections are associated with an increased risk of asthma, but how acute Th1 antiviral immune responses lead to chronic inflammatory Th2 disease remains undefined. We define a novel pathway that links transient viral infection to chronic lung disease with dendritic cell (DC) expression of the high-affinity IgE receptor (FcεRIα). In a mouse model of virus-induced chronic lung disease, in which Sendai virus triggered a switch to persistent mucous cell metaplasia and airway hyperreactivity after clearance of replicating virus, we found that FceRIa−/− mice no longer developed mucous cell metaplasia. Viral infection induced IgE-independent, type I IFN receptor–dependent expression of FcεRIα on mouse lung DCs. Cross-linking DC FcεRIα resulted in the production of the T cell chemoattractant CCL28. FceRIa−/− mice had decreased CCL28 and recruitment of IL-13–producing CD4+ T cells to the lung after viral infection. Transfer of wild-type DCs to FceRIa−/− mice restored these events, whereas blockade of CCL28 inhibited mucous cell metaplasia. Therefore, lung DC expression of FcεRIα is part of the antiviral response that recruits CD4+ T cells and drives mucous cell metaplasia, thus linking antiviral responses to allergic/asthmatic Th2 responses.
A single amino acid substitution in the V protein of Nipah virus alters its ability to block interferon signalling in cells from different species

The V protein of the paramyxovirus Nipah virus (NiV) has been shown to antagonize the interferon (IFN) response in human cells via sequestration of STAT1 and STAT2. This study describes a mutant of the NiV V protein, referred to as V(AAHL), that is unable to antagonize IFN signalling and demonstrates that a single amino acid substitution is responsible for its inactivity. The molecular basis for this was identified as a failure to interact with STAT1 and STAT2. It was also shown that NiV V, but not V(AAHL), was functional as an IFN antagonist in human, monkey, rabbit, dog, horse, pig and bat cells, which suggests that the ability of NiV to block IFN signalling is not a major constraint that prevents this virus from crossing species barriers.
Stage determination and therapeutic decision in human African trypanosomiasis: value of polymerase chain reaction and immunoglobulin M quantification on the cerebrospinal fluid of sleeping sickness patients in Côte d'Ivoire

In human African trypanosomiasis (HAT), two disease stages are defined: the first, or haemo‐lymphatic stage, and the second, or meningo‐encephalitic stage. Stage determination forms the basis of therapeutic decision and is of prime importance, as the drug used to cure second‐stage patients has considerable side‐effects. However, the tests currently used for stage determination have low sensitivity or specificity. Two new tests for stage determination in the cerebrospinal fluid (CSF) were evaluated on 73 patients diagnosed with HAT in Côte d'Ivoire. The polymerase chain reaction (PCR) detecting trypanosome DNA (PCR/CSF) is an indirect test for trypanosome detection whereas the latex agglutination test detecting immunoglobulin M (LATEX/IgM) is an indicator for neuro‐inflammation. Both tests were compared with classically used tests, double centrifugation and white blood cell count of the CSF. PCR/CSF appeared to be the most sensitive test (96%), and may be of use to improve stage determination. However, its value for therapeutic decision appears limited, as patients whose CSF was positive with PCR were successfully treated with pentamidine. This result confirms those of previous works that showed that some patients with trypanosomes in the CSF could be treated successfully with pentamidine. LATEX/IgM, which depending on the cut‐off, showed lower sensitivity of 76% and 88%, but higher specificity of 83% and 71% for LATEX/IgM 16 and LATEX/IgM 8 respectively, appears more appropriate for therapeutic decision making.
The Impact of Infectious Disease Specialist Consultation for Staphylococcus aureus Bloodstream Infections: A Systematic Review

Staphylococcus aureus is a common cause of severe bloodstream infection. We performed a systematic review to assess whether consultation with infectious disease specialists decreased all-cause mortality or rate of complications of S aureus bloodstream infections. The review also assessed parameters associated with the quality of management of the infection. We searched for eligible studies in PubMed, Embase, Scopus, and clinical trials.gov as well as the references of included studies. We identified 22 observational studies and 1 study protocol for a randomized trial. A meta-analysis was not performed because of the high risk of bias in the included studies. The outcomes are reported in a narrative review. Most included studies reported survival benefit, in the adjusted analysis. Recommended management strategies were carried out significantly more often among patients seen by an infectious disease specialist. Trials, such as cluster-randomized controlled trials, can more validly assess the studies at low risk of bias.
Bevacizumab Plus Irinotecan in Recurrent WHO Grade 3 Malignant Gliomas

Purpose: Although patients with newly diagnosed WHO grade 3 malignant glioma have a more favorable prognosis than those with WHO grade 4 malignant glioma, salvage therapies following recurrence offer essentially palliative benefit. We did a phase II trial of bevacizumab, a monoclonal antibody to vascular endothelial growth factor, in combination with irinotecan for patients with recurrent grade 3 malignant glioma. Experimental Design: Upon documentation of adequate safety among an initial cohort of nine patients treated with bevacizumab (10 mg/kg) and irinotecan every 14 days, a second cohort (n = 24) was treated with bevacizumab (15 mg/kg) every 3 weeks with irinotecan on days 1, 8, 22, and 29 of each 42-day cycle. For both cohorts, the dose of irinotecan was 340 mg/m2 for patients on enzyme-inducing antiepileptic drugs (EIAED) and 125 mg/m2 for patients not on EIAEDs. After each 6-week cycle, patients were evaluated with a physical examination and magnetic resonance imaging. Results: The 6-month progression-free survival was 55% (95% confidence interval, 36-70%). The 6-month overall survival was 79% (95% confidence interval, 61-89%). Twenty patients (61%) had at least a partial response. Outcome did not differ between the two treatment cohorts. Significant adverse events were infrequent and included a central nervous system hemorrhage in one patient, and one patient who developed thrombotic thrombocytopenic purpura. Conclusion: Bevacizumab and irinotecan is an active regimen with acceptable toxicity for patients with recurrent WHO grade 3 malignant glioma.
Intense Habitat-Specific Fisheries-Induced Selection at the Molecular Pan I Locus Predicts Imminent Collapse of a Major Cod Fishery

Predation is a powerful agent in the ecology and evolution of predator and prey. Prey may select multiple habitats whereby different genotypes prefer different habitats. If the predator is also habitat-specific the prey may evolve different habitat occupancy. Drastic changes can occur in the relation of the predator to the evolved prey. Fisheries exert powerful predation and can be a potent evolutionary force. Fisheries-induced selection can lead to phenotypic changes that influence the collapse and recovery of the fishery. However, heritability of the phenotypic traits involved and selection intensities are low suggesting that fisheries-induced evolution occurs at moderate rates at decadal time scales. The Pantophysin I (Pan I) locus in Atlantic cod (Gadus morhua), representing an ancient balanced polymorphism predating the split of cod and its sister species, is under an unusual mix of balancing and directional selection including current selective sweeps. Here we show that Pan I alleles are highly correlated with depth with a gradient of 0.44% allele frequency change per meter. AA fish are shallow-water and BB deep-water adapted in accordance with behavioral studies using data storage tags showing habitat selection by Pan I genotype. AB fish are somewhat intermediate although closer to AA. Furthermore, using a sampling design covering space and time we detect intense habitat-specific fisheries-induced selection against the shallow-water adapted fish with an average 8% allele frequency change per year within year class. Genotypic fitness estimates (0.08, 0.27, 1.00 of AA, AB, and BB respectively) predict rapid disappearance of shallow-water adapted fish. Ecological and evolutionary time scales, therefore, are congruent. We hypothesize a potential collapse of the fishery. We find that probabilistic maturation reaction norms for Atlantic cod at Iceland show declining length and age at maturing comparable to changes that preceded the collapse of northern cod at Newfoundland, further supporting the hypothesis. We speculate that immediate establishment of large no-take reserves may help avert collapse.
Effects of low-dose ketamine on succinylcholine-induced postoperative myalgia in outpatient surgeries: a randomized, double-blind study

Objective Despite the many complications of succinylcholine, it is still widely used as a superior muscle relaxant for rapid sequence induction. One of these complications is postoperative myalgia (POM). The aim of this study was to investigate the prophylactic effect of low-dose ketamine on the incidence and severity of POM. Materials and methods In this double-blind clinical study, a total of 148 patients scheduled for general anesthesia were randomly divided into two equal groups. Initially, in Group K, 0.5 mg/kg of ketamine was injected intravenously, whereas in Group N, the same volume (5 mL) of normal saline was injected. Thereafter, anesthesia was induced in all patients, by injecting 1.5 mg/kg of fentanyl and 2 mg/kg of propofol intravenously. Following the loss of eyelid reflex, 1.5 mg/kg of succinylcholine was injected intravenously as a muscle relaxant and then the patients were intubated. POM was defined as a pain with no surgical interferences, and its intensity was graded based on a four-point scale. The incidence and severity of myalgia were assessed by a blinded observer 24 hours after surgery. Results In terms of demographic data, the results of this study showed that there is no significant difference between patients in both groups (P>0.05). Overall, the incidence of POM in Group K was significantly less, when compared with Group N (P<0.05), but both groups were comparable based on the grade 2 of POM. After the induction of anesthesia, the systolic and diastolic blood pressure values were found to reduce in both groups (P<0.05). However, the changes were somehow similar, and repeated measures of variance analysis showed no significant difference in the two study groups (P>0.05). Conclusion The addition of 0.5 mg/kg of ketamine to propofol for the induction of anesthesia can be effective in reducing the incidence of low-grade POM.
Role of ADP Receptor P2Y12 in Platelet Adhesion and Thrombus Formation in Flowing Blood

ADP plays a central role in regulating platelet function. It induces platelet aggregation via the activation of 2 major ADP receptors, P2Y1 and P2Y12. We have investigated the role of P2Y12 in platelet adhesion and thrombus formation under physiological flow by using blood from a patient with a defect in the gene encoding P2Y12. Anticoagulated blood from the patient and from healthy volunteers was perfused over collagen-coated coverslips. The patient’s thrombi were smaller and consisted of spread platelets overlying platelets that were not spread, whereas control thrombi were large and densely packed. Identical platelet surface coverage, aggregate size, and morphology were found when a P2Y12 antagonist, N6-(2-methylthioethyl)-2-(3,3,3-trifluoropropylthio)-&bgr;,&ggr;-dichloromethylene ATP (also known as AR-C69931 MX), was added to control blood. The addition of a P2Y1 antagonist (adenosine-3′,5′-diphospate) to control blood resulted in small, but normally structured, thrombi. Thus, the ADP-P2Y12 interaction is essential for normal thrombus buildup on collagen. The patient’s blood also showed reduced platelet adhesion on fibrinogen, which was not due to changes in morphology. Comparable results were found by using control blood with AR-C69931 MX and also with adenosine-3′,5′-diphospate. This suggested that P2Y12 and P2Y1 were both involved in platelet adhesion on immobilized fibrinogen, thereby revealing it as ADP dependent. This was confirmed by complete inhibition on the addition of creatine phosphate/creatine phosphokinase.
Effect of Scaffold End Frame Carrying Strategies on Worker Stepping Response, Postural Stability, and Perceived Task Difficulty

Objective: This study determined the most favorable strategy for carrying scaffold end frames while minimizing the risk of injuries from being struck by an object, falling, and overexertion. Background: Scaffold erectors are at risk of high exposure to the aforementioned hazards associated with the dynamic human-scaffolding interface and work environments. Identifying an optimal work strategy can help reduce risk of injuries to the worker. Method: Three carrying methods, four types of work surfaces, two weights of scaffold frames, and three directions of stepping movement were tested in a laboratory with 18 construction workers. Results: The effects of carrying method on postural instability and task difficulty rating were significant for handling the 22-kg end frame. Response time, postural instability, and perceived task difficulty rating were significantly reduced when the 9-kg end frame was used as compared with the 22-kg frame. Conclusion: The symmetric side-carrying method was the best option for handling 22-kg scaffold end frames. A 9-kg end frame (e.g., made of reinforced lightweight materials) has the potential to reduce injury risk among scaffold handlers during their scaffold erection and dismantling jobs. Application: Scaffold erectors may want to adopt the symmetric side-carrying method as the primary technique for handling the 22-kg scaffold end frame, which is currently the one most used in the industry.