Miracle-dz/UniFAR-FTUs huggingface dataset:
Older breast cancer survivors: geriatric assessment domains are associated with poor tolerance of treatment adverse effects and predict mortality over 7 years of follow-up.

PURPOSE To evaluate geriatric assessment (GA) domains in relation to clinically important outcomes in older breast cancer survivors. METHODS Six hundred sixty women diagnosed with primary breast cancer in four US geographic regions (Los Angeles, CA; Minnesota; North Carolina; and Rhode Island) were selected with disease stage I to IIIA, age >or= 65 years at date of diagnosis, and permission from attending physician to contact. Data were collected over 7 years of follow-up from consenting patients' medical records, telephone interviews, physician questionnaires, and the National Death Index. Outcomes included self-reported treatment tolerance and all-cause mortality. Four GA domains were described by six individual measures, as follows: sociodemographic by adequate finances; clinical by Charlson comorbidity index (CCI) and body mass index; function by number of physical function limitations; and psychosocial by the five-item Mental Health Index (MHI5) and Medical Outcomes Study Social Support Survey (MOS-SSS). Associations were evaluated using t tests, chi(2) tests, and regression analyses. RESULTS In multivariable regression including age and stage, three measures from two domains (clinical and psychosocial) were associated with poor treatment tolerance; these were CCI >or= 1 (odds ratio [OR] = 2.49; 95% CI, 1.18 to 5.25), MHI5 score less than 80 (OR = 2.36; 95% CI, 1.15 to 4.86), and MOS-SSS score less than 80 (OR = 3.32; 95% CI, 1.44 to 7.66). Four measures representing all four GA domains predicted mortality; these were inadequate finances (hazard ratio [HR] = 1.89; 95% CI, 1.24 to 2.88; CCI >or= 1 (HR = 1.38; 95% CI, 1.01 to 1.88), functional limitation (HR = 1.40; 95% CI, 1.01 to 1.93), and MHI5 score less than 80 (HR = 1.34; 95% CI, 1.01 to 1.85). In addition, the proportion of women with these outcomes incrementally increased as the number of GA deficits increased. CONCLUSION This study provides longitudinal evidence that GA domains are associated with poor treatment tolerance and predict mortality at 7 years of follow-up, independent of age and stage of disease.
Toll-like receptor 8-mediated activation of murine plasmacytoid dendritic cells by vaccinia viral DNA

Plasmacytoid dendritic cells (pDCs) play a critical role in antiviral immunity through their ability to produce large amounts of type I IFNs. Activation of pDCs upon viral infection has been shown to be dependent on MyD88 and mediated by Toll-like receptors (TLR) 7 and 9, which sense viral ssRNA and CpG DNA, respectively. In this study, we showed that murine pDC recognition of vaccinia virus (VV), a dsDNA virus, was MyD88-dependent but TLR9-independent. Using HEK293 cells transfected with murine TLR7 or TLR8 and a NF-κB luciferase reporter, we demonstrated that stimulation of TLR8-, but not TLR7-, transfected cells with either VV or VV DNA resulted in substantial NF-κB activation, and that siRNA-mediated knockdown of TLR8 expression in pDCs led to a complete ablation of VV-induced type I IFN production. We further identified that the VV genome was rich in poly(A)/T sequences, and synthetic poly(A) and poly T oligodeoxynucleotides were capable of activating pDCs in a TLR8-dependent manner. In vivo, TLR8-MyD88-dependent pDC activation played a critical role in innate immune control of VV infection. Collectively, our data are unique in demonstrating that TLR8 is required for sensing poly(A)/T-rich DNA in pDCs, and that murine TLR8 is functional in the context of a viral infection.
Aerophagia, gastric, and supragastric belching: a study using intraluminal electrical impedance monitoring

Background: Patients with aerophagia are believed to have excessive belches due to air swallowing. Intraluminal impedance monitoring has made it possible to investigate the validity of this concept. Methods: The authors measured oesophageal pH and electrical impedance before and after a meal in 14 patients with excessive belching and 14 healthy controls and identified patterns of air transport through the oesophagus. The size of the gastric air bubble was measured radiographically. In four patients prolonged oesophageal manometry was performed simultaneously. Results: In all subjects, impedance tracings showed that a significant amount of air is propulsed in front of about a third of the swallow induced peristaltic waves. Two types of retrograde gas flow through the oesophagus (belch) were observed. In the first type air flowed from the stomach through the oesophagus in oral direction (“gastric belch”). In the second type air entered the oesophagus rapidly from proximal and was expulsed almost immediately in oral direction (“supragastric belch”). The incidence of air-containing swallows and gastric belches was similar in patients and controls but supragastric belches occurred exclusively in patients. There was no evidence of lower oesophageal sphincter relaxation during supragastric belches. Gastric air bubble size was not different between the two groups. Conclusions: In patients with excessive belching the incidence of gaseous reflux from stomach to oesophagus is similar to that in healthy subjects. Their excess belching activity follows a distinct pattern, characterised by rapid antegrade and retrograde flow of air in the oesophagus that does not reach the stomach.
Vorticella: A Protozoan for Bio-Inspired Engineering

In this review, we introduce Vorticella as a model biological micromachine for microscale engineering systems. Vorticella has two motile organelles: the oral cilia of the zooid and the contractile spasmoneme in the stalk. The oral cilia beat periodically, generating a water flow that translates food particles toward the animal at speeds in the order of 0.1–1 mm/s. The ciliary flow of Vorticella has been characterized by experimental measurement and theoretical modeling, and tested for flow control and mixing in microfluidic systems. The spasmoneme contracts in a few milliseconds, coiling the stalk and moving the zooid at 15–90 mm/s. Because the spasmoneme generates tension in the order of 10–100 nN, powered by calcium ion binding, it serves as a model system for biomimetic actuators in microscale engineering systems. The spasmonemal contraction of Vorticella has been characterized by experimental measurement of its dynamics and energetics, and both live and extracted Vorticellae have been tested for moving microscale objects. We describe past work to elucidate the contraction mechanism of the spasmoneme, recognizing that past and continuing efforts will increase the possibilities of using the spasmoneme as a microscale actuator as well as leading towards bioinspired actuators mimicking the spasmoneme.
Medium secure forensic psychiatry services

Background Regional medium secure developments have proceeded unevenly, with wide variations in resources to deliver services. Aims To compare patients admitted to seven (pre-reorganisation) regional services and styles of service delivery. Method A record survey of a complete sample of 2608 patients admitted on 3403 occasions between 1 January 1988 and 31 December 1994. Results Services differed according to location of patients before admission, their legal basis for detention, criminal and antisocial behaviour, diagnosis, security needs and length of stay. Regions with more resources and lower demand provided a wider range of services. Thames services were relatively under-provided during the study period, with North East Thames substantially reliant on admissions to private hospitals. Conclusions Uncoordinated development led to under-provision despite high demand. Certain regions prioritised offender patients and did not support local psychiatric services. New standards are required for service specification and resource allocation to redress inequality. Traditional performance measures were of limited usefulness in comparing services.
Prediction of total and visceral fat contents using anthropometric measures of adiposity in women.

BACKGROUND Although techniques such as dual energy xray absorptiometry (DXA) and quantitative CT are available to estimate global and regional adiposity, anthropometric measurements are often used to detect adiposity in clinical practice. OBJECTIVES To assess the association between the anthropometric measurements of obesity with total and regional fat mass determined by DXA. DESIGN A cross-sectional, descriptive study. Patients and method 106 healthy women volunteers, aged between 30 and 54 years were studied. Anthropometric measurements including body mass index (BMI), waist circumference (WC), hip circumference (HC), height adjusted WC (WC/HT), waist-hip ratio (WHR), and skin-fold thickness (SFT) over triceps, infrascapular, and iliac regions were made. All women underwent assessment of total fat mass (TFM) and visceral fat mass (VFM) using a Hologic DXA scan. RESULTS TFM and VFM showed positive correlations with all the anthropometric measurements examined, the strongest correlation was with BMI (r = 0.89 and 0.77 for TFM and VFM respectively, p < 0.001). Correlations of TFM with WC, HC, and WC/HT were 0.72, 0.87, and 0.65, (p < 0001 for all) respectively. Corresponding figures for VFM were 0.73, 0.74, and 0.68, (p < 0001 for all). WHR showed a poor correlation with TFM (r = 18, p = 0.09) and VFM (r = 0.33, p = 0.002). SFTs measured at three sites showed less strong correlations with TFM and VFM (r = 0.48 to 0.69, p < 0.001). CONCLUSIONS BMI has the strongest association with total and visceral fat mass among these women. Waist and hip circumferences showed high correlations with total and visceral fat mass, but adjusting waist circumference for height did not improve the correlation.
Robust Transceiver Design for Wireless Information and Power Transmission in Underlay MIMO Cognitive Radio Networks

In this letter, we investigate the robust transceiver design problem for simultaneous wireless information and power transfer in multiple-input-multiple-output underlay cognitive radio networks where the channel uncertainties are modeled by the worst-case model. Our objective is to maximize the sum harvested power at energy harvesting receivers while guaranteeing the required minimum mean-square-error at the secondary information-decoding (ID) receiver and the interference constraints at the primary receivers. We propose to alternatively optimize the transmit covariance matrix at secondary transmitter and the preprocessing matrix at secondary ID receiver. Simulation results have shown that the robust transceiver design has significant performance gain over the non-robust one.
Soils of the Aversa plain (southern Italy)

ABSTRACT The Aversa plain is one of the most important agricultural areas of the Campania region, combining the presence of very fertile soils, sites of great archaeological interest and growing residential urbanization. In this paper, the soil map (1:50,000 scale) of the Aversa plain is presented. Three main land systems (coastal, alluvial and foothill plains) characterized by different soil types (Andosols, Phaeozems, Cambisols, Vertisols, Arenosols, Histosols, Luvisols) have been identified. However, Andosols are the most widespread soil type (9768 ha) and, along with part of the Phaeozems and Cambisols, represent the most fertile soils of the Aversa plain (first and second classes of the land capability classification). In order to evaluate recent intense soil sealing, its impact over land capability classes was assessed during the last 60 years. Results show that soil sealing in the Aversa plain affected mainly the most fertile first- and second-class soils.
Optimal Intrinsic Descriptors for Non-Rigid Shape Analysis

We propose novel point descriptors for 3D shapes with the potential to match two shapes representing the same object undergoing natural deformations. These deformations are more general than the often assumed isometries, and we use labeled training data to learn optimal descriptors for such cases. Furthermore, instead of explicitly defining the descriptor, we introduce new Mercer kernels, for which we formally show that their corresponding feature space mapping is a generalization of either the Heat Kernel Signature or the Wave Kernel Signature. I.e. the proposed descriptors are guaranteed to be at least as precise as any Heat Kernel Signature or Wave Kernel Signature of any parameterisation. In experiments, we show that our implicitly defined, infinite-dimensional descriptors can better deal with non-isometric deformations than state-of-the-art methods.
Nuclear Accumulation of Globular Actin as a Cellular Senescence Marker

We evaluated the nuclear actin accumulation as a new marker of cellular senescence, using human diploid fibroblast (HDF), chondrocyte primary cultures, Mv1Lu epithelial cells, and Huh7 cancer cells. Nuclear accumulation of globular actin (G-actin) and dephosphorylated cofilin was highly significant in the senescent HDF cells, accompanied with inhibition of LIM kinase (LIMK) -1 activity. When nuclear export of the actin was induced by 12-O-tetradecanoylphorbol-13-acetate, DNA synthesis of the senescent cells increased significantly, accompanied with changes of morphologic and biochemical profiles, such as increased RB protein phosphorylation and decreased expressions of p21WAF1, cytoplasmic p-extracellular signal-regulated kinase 1/2, and caveolins 1 and 2. Significance of these findings was strengthened additionally by the fact that nuclear actin export of young HDF cells was inhibited by the treatment with leptomycin B and mutant cofilin transfection, whose LIMK-1 phosphorylation site was lost, and the old cell phenotypes were duplicated with nuclear actin accumulation, suggesting that nuclear actin accumulation was accompanied with G1 arrest during cellular senescence. The aforementioned changes were observed not only in the replicative senescence but also in the senescence induced by treatment of HDF cells, Mv1Lu, primary culture of human chondrocytes, or Huh7 cells with H-ras virus infection, hydroxyurea, deferoxamine, or H2O2. Nuclear actin accumulation was much more sensitive and an earlier event than the well-known, senescence-associated β-galactosidase activity.
KKL, Kruskal-Katona, and Monotone Nets

We generalize the Kahn-Kalai-Linial (KKL) Theorem to random walks on Cayley and Schreier graphs, making progress on an open problem of Hoory, Linial, and Wigderson. In our generalization, the underlying group need not be abelian so long as the generating set is a union of conjugacy classes.
Sun safety knowledge and practice in UK postal delivery workers

Background Postal delivery workers spend a large proportion of their work time outdoors, placing them at increased risk of skin cancer. To date, no studies have examined occupational sun safety knowledge and practice within this group in the UK. Aims To describe the occupational sun safety knowledge and practice of UK postal delivery workers and to investigate the association of demographic, personal and occupational factors with knowledge and practice in order to identify potential strategies for improving sun safety in this occupational group. Methods Postal delivery workers completed a questionnaire that collected data on occupational sun safety knowledge and practice in addition to demographic, personal and workplace characteristics. One-way analysis of variances were applied to assess differences in knowledge and practice by these characteristics. Results A total of 1153 postal delivery workers completed the questionnaire, a 60% response rate. Thirty-three per cent reported receiving sun safety training within the previous 12 months. The majority of respondents reported correct knowledge on three of the six domains and good practice on four of the six behavioural domains. However, only one-fifth of respondents reported wearing sunglasses and ensuring a plentiful intake of water. Knowledge and practice differed significantly according to demographic, personal and workplace characteristics. Conclusions There is a need to raise the profile of occupational skin cancer in this occupational group and to increase the priority given to occupational sun safety policies alongside targeted and tailored interventions, the effect of which can be evaluated.
TLR sensing of bacterial spore-associated RNA triggers host immune responses with detrimental effects

The spores of pathogenic bacteria are involved in host entry and the initial encounter with the host immune system. How bacterial spores interact with host immunity, however, remains poorly understood. Here, we show that the spores of Bacillus anthracis (BA), the etiologic agent of anthrax, possess an intrinsic ability to induce host immune responses. This immunostimulatory activity is attributable to high amounts of RNA present in the spore surface layer. RNA-sensing TLRs, TLR7, and TLR13 in mice and their human counterparts, are responsible for detecting and triggering the host cell response to BA spores, whereas TLR2 mediates the sensing of vegetative BA. BA spores, but not vegetative BA, induce type I IFN (IFN-I) production. Although TLR signaling in itself affords protection against BA, spore RNA–induced IFN-I signaling is disruptive to BA clearance. Our study suggests a role for bacterial spore–associated RNA in microbial pathogenesis and illustrates a little known aspect of interactions between the host and spore-forming bacteria.
A qualitative analysis of an electronic health record (EHR) implementation in an academic ambulatory setting.

OBJECTIVES To determine pre-implementation perspectives of institutional, practice and vendor leadership regarding best practice for implementation of two ambulatory electronic health records (EHRs) at an academic institution. DESIGN Semi-structured interviews with ambulatory care network and information systems leadership, medical directors, practice managers and vendors before EHR implementation. Results were analysed using grounded theory with ATLAS.ti version 5.0. MEASUREMENTS Qualitative data on perceived benefits of EHRs as well as facilitators and barriers to successful implementation. RESULTS Interviewees perceived data accessibility, quality and safety measurement, improvement and reporting as benefits of EHR use. Six themes emerged for EHR implementation best practice: effective communication; successful system migration; sufficient hardware, technical equipment, support and training; safeguards for patient privacy; improved efficiency; and a sustainable business plan. CONCLUSIONS Achieving the benefits of EHRs identified by our interviewees depends on successful implementation and use. Further identification of best implementation practices for EHRs is required, given the financial and clinical consequences of poor implementation.
Transparent dynamic instrumentation

Process virtualization provides a virtual execution environment within which an unmodified application can be monitored and controlled while it executes. The provided layer of control can be used for purposes ranging from sandboxing to compatibility to profiling. The additional operations required for this layer are performed clandestinely alongside regular program execution. Software dynamic instrumentation is one method for implementing process virtualization which dynamically instruments an application such that the application's code and the inserted code are interleaved together. DynamoRIO is a process virtualization system implemented using software code cache techniques that allows users to build customized dynamic instrumentation tools. There are many challenges to building such a runtime system. One major obstacle is transparency. In order to support executing arbitrary applications, DynamoRIO must be fully transparent so that an application cannot distinguish between running inside the virtual environment and native execution. In addition, any desired extra operations for a particular tool must avoid interfering with the behavior of the application. Transparency has historically been provided on an ad-hoc basis, as a reaction to observed problems in target applications. This paper identifies a necessary set of transparency requirements for running mainstream Windows and Linux applications. We discuss possible solutions to each transparency issue, evaluate tradeoffs between different choices, and identify cases where maintaining transparency is not practically solvable. We believe this will provide a guideline for better design and implementation of transparent dynamic instrumentation, as well as other similar process virtualization systems using software code caches.
Spectrum of ST-T–Wave Patterns and Repolarization Parameters in Congenital Long-QT Syndrome: ECG Findings Identify Genotypes

Background—Congenital long-QT syndrome (LQTS) is caused by mutations of genes encoding the slow component of the delayed rectifier current (LQT1, LQT5), the rapid component of the delayed rectifier current (LQT2, LQT6), or the Na+ current (LQT3), resulting in ST-T–wave abnormalities on the ECG. This study evaluated the spectrum of ST-T–wave patterns and repolarization parameters by genotype and determined whether genotype could be identified by ECG. Methods and Results—ECGs of 284 gene carriers were studied to determine ST-T–wave patterns, and repolarization parameters were quantified. Genotypes were identified by individual ECG versus family-grouped ECG analysis in separate studies using ECGs of 146 gene carriers from 29 families and 233 members of 127 families undergoing molecular genotyping, respectively. Ten typical ST-T patterns (4 LQT1, 4 LQT2, and 2 LQT3) were present in 88% of LQT1 and LQT2 carriers and in 65% of LQT3 carriers. Repolarization parameters also differed by genotype. A combination of quantified repolarization parameters identified genotype with sensitivity/specificity of 85%/70% for LQT1, 83%/94% for LQT2, and 47%/63% for LQT3. Typical patterns in family-grouped ECGs best identified the genotype, being correct in 56 of 56 (21 LQT1, 33 LQT2, and 2 LQT3) families with mutation results. Conclusions—Typical ST-T–wave patterns are present in the majority of genotyped LQTS patients and can be used to identify LQT1, LQT2, and possibly LQT3 genotypes. Family-grouped ECG analysis improves genotype identification accuracy. This approach can simplify genetic screening by targeting the gene for initial study. The multiple ST-T patterns in each genotype raise questions regarding the pathophysiology and regulation of repolarization in LQTS.