Miracle-dz/UniFAR-FTUs huggingface dataset:
Clinicians’ use of sexual knowledge assessment tools for people with intellectual disability

ABSTRACT Background Many people with intellectual disability have limited sexual knowledge. Several assessment tools have been developed to assess the sexual knowledge of people with intellectual disability. This paper examines how clinicians’ are using these tools. Method This research uses a constructivist grounded theory approach. Semistructured qualitative interviews were conducted with clinicians who use sexual knowledge assessment tools. Findings and Discussion Assessment of sexual knowledge is not routine in disability service provision. Sexual knowledge is typically only assessed when there has been an incident of problematic sexualised behaviour. This reactive approach perpetuates a pathological sexual health discourse. Conclusions Clinicians using assessment tools said that they need the tools to support work they do in relation to sexual health of people with intellectual disability. However, they also reported that the tools have gaps and are not fully meeting their needs or the needs of people with intellectual disability.
The Dimensionality of Contextual and Citizenship Performance in Military Recruits: Support for Nine Dimensions Using Self-, Peer, and Supervisor Ratings

Organizational Citizenship Behavior and Contextual Performance make up a domain that can be referred to as Contextual and Citizenship Performance (CCP). CCP is essential to assess and promote in military and civilian organizations because it defines the “good soldier” prototype. Unfortunately, extant research has led to confusion as to whether CCP consists of one, two, three, six, or nine dimensions. We shed new light on the composition of CCP by evaluating one-, two-, three-, six-, and nine-dimensional theoretical models using supervisor, self-, and peer ratings of military recruits undergoing basic training. We employed Relative Percentile Method ratings to improve distinctions among ratees when the level of CCP is high. Contrary to much recent literature, our results supported a nine-dimensional theoretical model in all three rating sources. Thus, conceptualizing, assessing and promoting the proverbial “good soldier” may require a more highly nuanced perspective of CCP than is generally acknowledged.
Distribution of Tetrahydromethanopterin-Dependent Enzymes in Methylotrophic Bacteria and Phylogeny of Methenyl Tetrahydromethanopterin Cyclohydrolases

ABSTRACT The methylotrophic proteobacterium Methylobacterium extorquens AM1 possesses tetrahydromethanopterin (H4MPT)-dependent enzymes, which are otherwise specific to methanogenic and sulfate-reducing archaea and which have been suggested to be involved in formaldehyde oxidation to CO2 in M. extorquens AM1. The distribution of H4MPT-dependent enzyme activities in cell extracts of methylotrophic bacteria from 13 different genera are reported. H4MPT-dependent activities were detected in all of the methylotrophic and methanotrophic proteobacteria tested that assimilate formaldehyde by the serine or ribulose monophosphate pathway. H4MPT-dependent activities were also found in autotrophic Xanthobacter strains. However, no H4MPT-dependent enzyme activities could be detected in other autotrophic α-proteobacteria or in gram-positive methylotrophic bacteria. Genes encoding methenyl H4MPT cyclohydrolase (mch genes) were cloned and sequenced from several proteobacteria. Bacterial and archaeal Mch sequences have roughly 35% amino acid identity and form distinct groups in phylogenetic analysis.
Mediators of change in cognitive behaviour therapy and mebeverine for irritable bowel syndrome

Background Cognitive behaviour therapies (CBTs) have through several trials been demonstrated to reduce symptoms and disability in irritable bowel syndrome (IBS) patients, but the mechanisms responsible for the changes are still unknown. The aim of this study was to test a theoretical model of CBT and investigate if cognitions and/or behaviour mediated the changes seen in CBT for IBS. Method To assess for possible mediating effects, we applied path analysis to the dataset of 149 diagnosed participants randomized to mebeverine hydrochloride plus CBT or mebeverine hydrochloride alone. Primary outcome was symptom severity, while secondary outcomes were work and social adjustment and anxiety. Results The path analyses supported mediational paths for all outcomes. Changes in behaviour and cognitions mediated all three outcomes, with models placing behaviour change ‘upstream’ of cognition change having best fit. The analyses of model fits revealed best fit for the anxiety model and hence provide increased confidence in the causal model of anxiety. Conclusions Changes in behaviour and cognitions mediate the change in CBT given to IBS patients. The results strengthen the validity of a theoretical model of CBT by confirming the interaction of cognitive, emotional and behavioural factors in IBS.
Single objective real-parameter optimization: Algorithm jSO

Solving single objective real-parameter optimization problems, also known as a bound-constrained optimization, is still a challenging task. We can find such problems in engineering optimization, scientific applications, and in other real-world problems. Usually, these problems are very complex and computationally expensive. A new algorithm, called jSO, is presented in this paper. The algorithm is an improved variant of the iL-SHADE algorithm, mainly with a new weighted version of mutation strategy. The experiments were performed on CEC 2017 benchmark functions, which are different from previous competition benchmark functions. A comparison of the proposed jSO algorithm and the L-SHADE algorithm is presented first. From the obtained results we can conclude that jSO performs better in comparison with the L-SHADE algorithm. Next, a comparison of jSO and iL-SHADE is also performed, and jSO obtained better or competitive results. Using the CEC 2017 evaluation method, jSO obtained the best final score among these three algorithms.
Influence of situational variables on changes in state body image among Black and White women

INFLUENCE OF SITUATIONAL VARIABLES ON CHANGES IN STATE BODY IMAGE AMONG BLACK AND WHITE WOMEN Amanda M. Rahimi, Ph.D. George Mason University, 2010 Dissertation Director: Dr. Jonathan J. Mohr Although research suggests that body esteem varies according to daily experiences (Melnyk, Cash, & Janda, 2004; Tiggemann, 2001), few studies have examined situational variables that may lead to fluctuations in body satisfaction. Of the limited experimental research, results suggest that a variety of experiences, including interpersonal feedback, clothing selection, and media exposure, may trigger changes in body esteem (Grabe, Ward, & Hyde, 2008; Kwon & Shim, 1999; Mills & Miller, 2007). The main goal of this study was to examine within-person variability of state body image and situational experiences that influence changes in state body image among college women in their everyday lives. A secondary aim was to examine how race and appearance investment moderate this effect. A pilot study was conducted to examine situational experiences related to changes in body esteem. Eleven Black American (BA) and 11 White American (WA) women recorded their body experiences and feelings in a journal for one week and results were used to create a simple checklist that was used in the main study. Participants in the main study included 40 BA and 42 WA undergraduate women (ages 18-28). Participants completed a measure of appearance investment on Day 1, and a state body image measure and a situational experience checklist online twice daily for the next seven days. Results were analyzed using hierarchical linear modeling (HLM), a method that accounts for nonindependence of observations. Findings revealed considerable within-person variability in body image. Every event type was uniquely associated with changes in body image except dissatisfaction while exercising. All of the interactions between race and situational variables were nonsignificant, indicating that the association between situational experiences and changes in state body image did not depend on an individual’s race. Appearance investment was only found to be a significant moderator of the association between state body image and exercise dissatisfaction. Potential limitations of these findings are discussed along with suggestions for future research examining the effects of positive and negative experiences on state body image.
Trends: Women and Sexual Orientation in the Military

Cet article examine l'attitude des Americains envers les femmes militaires entre 1940 et 2002, ainsi qu'envers l'homosexualite dans l'armee, entre 1977 et 2001. Une acceptation croissante par l'opinion publique americaine des femmes et des homosexuels dans l'armee est constatee, mais l'opinion reste reservee quant a la place des femmes dans le combat
Pneumococcal sepsis with hemolytic-uremic syndrome in the adult.

F.E. von Eyben, PhD, MD, Klovervanget 22 a 11, DK-5000 Odense (Denmark) Dear Sir, Hemolytic-uremic syndrome comprises a triad of findings: acute microangiopathic hemolytic anemia, thrombocytopenia, and acute renal insufficiency [1]. In most cases of hemolytic-uremic syndrome in the adult the etiology is unknown, but a few cases have been reported as complications of typhoid fever [2], E. coli and Pseudo-monas septicemia [3, 4], and mumps [3]. We report an adult patient with the syndrome who had a fulminant pneumococcal infection. A 35-year-old man had undergone splenectomy at the age of 14 and had been in good health until the present disorder. On admission he was intermittently confused
Are Simple Renal Cysts in Childhood Associated With Kidney Stones?

The renal tubules, in their various segments, are mainly responsible for the final composition of urine from glomerular ultrafiltrate. In a complex process involving resorption and secretion mechanisms, the tubules are responsible for retaining substances in the body, some substances are recovered almost 100% such as water and sodium chloride. Tubulopathies are a group of diseases where these selection mechanisms are impaired; they can be simple or complex depending on the number of the dysfunctional mechanisms. Nevertheless, tubules may present both morphological and structural abnormalities. Some of these abnormalities can be congenital (development abnormalities) usually on a genetic basis. Some are malformations (renal multicystic dysplasia), some others hereditary diseases (AR polycystic kidney). Other morphologic tubular diseases can develop after birth as part of genetic diseases such as AD polycystic kidney disease, tuberous sclerosis or medullary cystic disease.
Role Playing and Identity: The Limits of Theatre as Metaphor

Acknowledgments Prologue Part One: Theatre and the Reality of Appearance I. What Is Theatre? II. What Is Phenomenology? III. Theory of Enactment IV. Theory of Appearance V. Variations On The Theatrical Theme of Standing In and Authorization 1. The OWorldO of Oedipus Rex and the World of Its Theatre 2. The OWorldO of Hamlet and the World of Its Theatre 3. The OWorldO of Waiting for Godot and the World of Its Theatre 4. Summary of the Variations and the Nature of a Text VI. Theatre as Metraphor and Play As Disclosure VII. Second Set of Variations on the Theatrical Theme of Standing In and Authorization 1. Eugene Ionesco and the Potentiality of Being-with-Others in ORolesO--Fallenness 2. Robert Wilson and the Potentiality of Projection of Possibility--Understanding 3. Jerzy Grotowski and the Potentiality of Attunement to the World--Mood VIII. Theatre and the Question of the Truth of Art Part Two: Reality and the Self IX. Space, Time, and Identity of Self X. Self as Body-Self XI. Body-Self and Others: Cognition, Expression, Mimetic Response, and Transformation XII. Body-Self, Other Body-Selves, and Self-Deception XIV. Identity and Theatre-Like Disengagement From Engulfment XV. Existence and Art: Self as Memorializaing Structure of Possibilities XVI. Summary and Prospects: Identity of Self Part Three: The Limits of Appearance and the Limits of Theatrical Metaphor XVII. Theatre as Metaphor XVIII. The Truth of Art and the Limits of Theatre as Metaphor XIX. The Limits of Theatrical Metaphors 1. The OArt of LifeO 2. Erving GoffmanOs ORole TheoryO XX. The Limits of Appearance Index
Prolongation of the corrected QT interval in adult patients with anti-Ro/SSA-positive connective tissue diseases.

OBJECTIVE Newborns of mothers positive for anti-Ro/SSA autoantibodies may develop a series of electrocardiographic (EKG) disturbances. Prolongation of the corrected QT (QTc) interval was recently reported in a significant proportion of children with maternally acquired anti-Ro/SSA antibodies, with a concomitant disappearance of EKG abnormalities and acquired maternal autoantibodies during the first year, suggesting a direct, reversible electrophysiologic effect of anti-Ro/SSA antibodies on the ventricular repolarization. On this basis, we investigated whether these antibodies may also affect cardiac repolarization in anti-Ro/SSA-positive adult patients with connective tissue diseases. METHODS Fifty-seven patients with connective tissue diseases were selected: 31 had anti-Ro/SSA antibodies and 26 did not (controls). In all subjects, we analyzed the QTc interval, heart rate variability, and signal-averaged high-resolution EKG recording. RESULTS Anti-Ro/SSA-positive patients showed a significant prolongation of the mean QTc interval compared with the controls (mean +/- SD 445 +/- 21 versus 419 +/- 17 msec; P = 0.000005). Eighteen of the 31 anti-Ro/SSA-positive patients (58%) and none of the 26 anti-Ro/SSA-negative patients had QTc values above the upper limit of normal (440 msec). Both groups had a reduction in heart rate variability, with a prevalence for the sympathetic nervous system and a high incidence of ventricular late potentials; these values were not significantly different between the 2 groups. CONCLUSION Adult patients with anti-Ro/SSA-positive connective tissue diseases showed a high prevalence of QTc interval prolongation. This feature, with the concomitant abnormalities in the autonomic tone and ventricular late excitability observed in all patients studied, suggests that anti-Ro/SSA-positive patients may have a particularly high risk of developing life-threatening arrhythmias.
Secure Skyline Queries on Cloud Platform

Outsourcing data and computation to cloud server provides a cost-e ective way to support large scale data storage and query processing. However, due to security and privacy concerns, sensitive data (e.g., medical records) need to be protected from the cloud server and other unauthorized users. One approach is to outsource encrypted data to the cloud server and have the cloud server perform query processing on the encrypted data only. It remains a challenging task to support various queries over encrypted data in a secure and e cient way such that the cloud server does not gain any knowledge about the data, query, and query result. In this paper, we study the problem of secure skyline queries over encrypted data. The skyline query is particularly important for multicriteria decision making but also presents significant challenges due to its complex computations. We propose a fully secure skyline query protocol on data encrypted using semanticallysecure encryption. As a key subroutine, we present a new secure dominance protocol, which can be also used as a building block for other queries. Finally, we provide both serial and parallelized implementations and empirically study the protocols in terms of e ciency and scalability under di erent parameter settings, verifying the feasibility of our proposed solutions.
Angiogenic Index: A New Method for Assessing Microvascularity in Breast Carcinoma with Possible Prognostic Implications

Abstract: The quantitation of microvessels in breast cancer in sections immunolabeled for factor VIII, CD‐34, or CD‐31 currently is expressed as numbers of vessels/mm2. In an attempt to perform a more accurate method for counting microvessels, we determined the number of microvessels by 1,000 tumor cells (angiogenic index; AI). This new method minimizes the possible variations concerning the width of the microscopic fields, stroma/epithelium relations, and cellular tumor size. The present study compares the number of vessels determined by the traditional method (vessels/mm2) and AI in a series of 215 cases of ductal infiltrating carcinoma not otherwise specified. Also we studied the degree of correlation between both methods and with pathologic variables (tumor size, histologic grade, mitotic count, tumor necrosis, vascular invasion, skin infiltration, and axillary lymph node metastasis). Our results showed that the AI correlates more significantly than the classic microvessel density determination with other prognostic factors in breast cancer. In histologic grade III tumors, high AI correlates significantly with the presence of more than three axillary lymph nodes metastases. Therefore we recommend determining the degree of tumor angiogenesis by counting vessels per 1,000 tumor cells (AI) because of its reliable determination and significant correlation with other prognostic factors.
An Analytical Model of Leakage Neutron Equivalent Dose for Passively-Scattered Proton Radiotherapy and Validation with Measurements

Exposure to stray neutrons increases the risk of second cancer development after proton therapy. Previously reported analytical models of this exposure were difficult to configure and had not been investigated below 100 MeV proton energy. The purposes of this study were to test an analytical model of neutron equivalent dose per therapeutic absorbed dose (H/D) at 75 MeV and to improve the model by reducing the number of configuration parameters and making it continuous in proton energy from 100 to 250 MeV. To develop the analytical model, we used previously published H/D values in water from Monte Carlo simulations of a general-purpose beamline for proton energies from 100 to 250 MeV. We also configured and tested the model on in-air neutron equivalent doses measured for a 75 MeV ocular beamline. Predicted H/D values from the analytical model and Monte Carlo agreed well from 100 to 250 MeV (10% average difference). Predicted H/D values from the analytical model also agreed well with measurements at 75 MeV (15% average difference). The results indicate that analytical models can give fast, reliable calculations of neutron exposure after proton therapy. This ability is absent in treatment planning systems but vital to second cancer risk estimation.
Mutual information of words and pictures

There is described a mixture of sodium cromoglycate of mass median diameter from 2 to 30 microns with a pharmaceutically acceptable water soluble carrier of sieve size from 200 to 1000 microns, the carrier having a solubility of greater than 1 to 5 by weight in water at 20 DEG C. The mixture is useful in the treament of conditions of the gastrointestinal tract.
Biomechanics of octopedal locomotion: kinematic and kinetic analysis of the spider Grammostola mollicoma

SUMMARY Despite the abundance of octapodal species and their evolutionary importance in originating terrestrial locomotion, the locomotion mechanics of spiders has received little attention so far. In this investigation we use inverse dynamics to study the locomotor performance of Grammostola mollicoma (18 g). Through 3-D kinematic measurements, the trajectory of the eight limbs and cephalothorax or abdomen allowed us to estimate the motion of the body centre of mass (COM) at different speeds. Classic mechanics of locomotion and multivariate analysis of several variables such as stride length and frequency, duty factor, mechanical external work and energy recovery, helped to identify two main gaits, a slow (speed <11 cm s–1) one and a fast one characterised by distinctive 3-D trajectories of COM. The total mechanical work (external + internal) calculated in the present study and metabolic data from the literature allowed us to estimate the locomotion efficiency of this species, which was less than 4%. Gait pattern due to alternating limb support, which generates asymmetrical COM trajectories and a small but consistent energy transfer between potential and kinetic energies of COM, is discussed both in terms of coordination indices and by referring to the octopod as formed by two quadrupeds in series. Analogies and differences of the newly obtained parameters with the allometric data and predictions are also illustrated.
Clinical tolerance in allogeneic hematopoietic stem cell transplantation

Summary: Allogeneic hematopoietic stem cell transplantation (HSCT) has been a curative therapeutic option for a wide range of immune hematologic malignant and non‐malignant disorders including genetic diseases and inborn errors. Once in the host, allogeneic transplanted cells have not only to ensure myeloid repopulation and immunological reconstitution but also to acquire tolerance to host human leukocyte antigens via central or peripheral mechanisms. Peripheral tolerance after allogeneic HSCT depends on several regulatory mechanisms aimed at blocking alloimmune reactivity while preserving immune responses to pathogens and tumor antigens. Patients transplanted with HSCT represent an ideal model system in humans to identify and characterize the key cellular and molecular players underlying these mechanisms. The knowledge gained from these studies has allowed the development of novel therapeutic strategies aimed at inducing long‐term peripheral tolerance, which can be applicable not only in allogeneic HSCT but also in autoimmune diseases and solid‐organ transplantation. In the present review, we describe Type 1 regulatory T cells, initially discovered and characterized in chimeric patients transplanted with human leukocyte antigen‐mismatched HSCT, and how their presence correlates to tolerance induction and maintenance. Furthermore, we summarize different cell therapy approaches with regulatory T cells, designed to facilitate tolerance induction, minimizing pharmaceutical interventions.
Confessions of an Occupational Therapist Who Became a Detective

This life history of an occupational therapist traces her evolution from a biomedical technician to a ‘detective’, who searches for new ideas that will support clinical practice and enable the profession to achieve its potential contribution to humankind. These ideas focus on ‘homo occupacio’, the occupational human: an agent who sets goals, makes choices and becomes competent through engagement in occupation. Concepts such as motivation, self-organisation, skill development, resource reclamation, brain evolution, repertoires of daily routines, environmental management and defining health as the capacity to achieve one's valued goals illuminate occupation. The contexts in which people carry out their rounds of occupation also require study in order for occupational therapists to pose a ‘just right’ level of environmental challenge, enabling people to make an adaptive response in user-friendly environments. Recommended sources for new ideas are, first, self-reports of people who live with impairments and, second, literature from non-medical disciplines that share occupational therapy's holistic, integrated and optimistic view of people. The writings of people who live with chronic conditions reveal that they are not being served well by the current biomedical system. In contrast, scholarly detective work could foster occupational therapy that enhances satisfaction in daily living, influences health, reclaims resources and enables equality of capability for myriads of the world's populations. A keynote address, given on 8 September 1999 at the Inaugural United Kingdom Occupational Science Symposium, held at the College of Ripon and York St John, York.