Miracle-dz/UniFAR-FTUs huggingface dataset:
Differential Metabolism of Gefitinib and Erlotinib by Human Cytochrome P450 Enzymes

Purpose: To examine the enzyme kinetics of gefitinib and erlotinib metabolism by individual cytochrome P450 (CYP) enzymes, and to compare their effects on CYP3A activity, with the aim to better understand mechanisms underlying pharmacokinetic variability and clinical effects. Experimental Design: Enzyme kinetics were examined by incubating gefitinib or erlotinib (1.5-50 μmol/L) with recombinant human CYP3A4, CYP3A5, CYP2D6, CYP1A1, CYP1A2, and CYP1B1 (10-160 pmol/mL). Their effects on CYP3A activity were examined by comparing midazolam metabolism in the presence and absence of gefitinib or erlotinib in human liver and intestinal microsomes. Parent compounds and metabolites were monitored by high-performance liquid chromatography with a photodiode detector or tandem mass spectrometer. Results: Both drugs were metabolized primarily by CYP3A4, CYP3A5, and CYP1A1, with respective maximum clearance (Clmax) values for metabolism of 0.41, 0.39, and 0.57 mL/min/nmol for gefitinib and 0.24, 0.21, 0.31 mL/min/nmol for erlotinib. CYP2D6 was involved in gefitinib metabolism (Clmax, 0.63 mL/min/nmol) to a large extent, whereas CYP1A2 was considerably involved in erlotinib metabolism (Clmax, 0.15 mL/min/nmol). Both drugs stimulated CYP3A-mediated midazolam disappearance and 1-hydroxymidazolam formation in liver and intestinal microsomes. Conclusions: Gefitinib is more susceptible to CYP3A-mediated metabolism than erlotinib, which may contribute to the higher apparent oral clearance observed for gefitinib. Metabolism by hepatic and extrahepatic CYP1A may represent a determinant of pharmacokinetic variability and response for both drugs. The differential metabolizing enzyme profiles suggest that there may be differences in drug-drug interaction potential and that stimulation of CYP3A4 may likely play a role in drug interactions for erlotinib and gefitinib.
Uniaxial Tension Test of Slender Reinforced Early Age Concrete Members

The present study aims to obtain the tensile properties of early age concrete based on a uniaxial tension test employing RC slender members. First, the paper shows that concrete strain is equal to the strain of rebar at the mid-span of the RC member. The tensile Young’s modulus and the strain capacity of early age concrete are estimated using strain measurements. The experiment indicated that the tensile Young’s modulus at an early age is higher than the compressive modulus. This observation was similar to one found in a previous investigation which used a direct tension test of early age concrete. Moreover, the paper describes how an empirical equation for mature concrete can be applied to the relation between uniaxial tensile strength and splitting tensile strength even in early age concrete. Based on a uniaxial tension test, the paper proposes an empirical equation for the relationship between standard bond stresses and relative slip.
Angiotensinogen M235T and T174M Gene Polymorphisms in Combination Doubles the Risk of Mortality in Heart Failure

Angiotensinogen M235T and T174M polymorphisms have individually been associated with elevated levels of plasma angiotensinogen, hypertension, and left ventricular hypertrophy. In this study, heart failure patients (n=451) were genotyped for the angiotensinogen M235T and T174M polymorphisms to investigate association with survival (recorded over 4 years of follow-up) and prognostic hormone markers. Patients carrying the 235TT genotype (n=86) were 3 years younger at admission (P=0.011), and, in those with hypertension, diagnosis was made ≈10 years earlier than other patients. Patients carrying ≥1 174M allele (n=94) were more likely to have a previous history of heart failure (P=0.044) and increased mortality during follow-up (risk ratio: 1.69, 95% CI: 1.03 to 2.79; P=0.038) compared with 174TT homozygotes (n=355), despite having a higher left ventricular ejection fraction (P=0.009). “High-risk” genotype combinations (defined a priori as 235TT and/or ≥1 174M allele; n=144; 32%) were independently predictive of mortality, conferring a 2-fold greater risk of dying during the follow-up period (odds ratio: 2.0; 95% CI: 1.3 to 3.0; P=0.001). This study suggested that angiotensinogen gene variants M235T and T174M may provide prognostic information for long-term survival in heart failure patients.
On the Aggregate and Distributional Implications of Productivity Differences Across Countries

We develop a quantitative theory of human capital with heterogeneous agents in order to assess the sources of cross-country income differences. The cross-sectional implications of the theory and U.S. data are used to restrict the parameters of human capital technology. We then assess the model's ability to explain the cross-country data. Our quantitative model generates a total-factor-productivity (TFP) elasticity of output per worker of 2.8. This implies that a factor of 3 difference in TFP is amplified through physical and human capital accumulation to generate a factor of 20 difference in output per worker --- as observed in the data between rich and poor countries. The implied difference in TFP is in the range of estimates from micro studies. The theory suggests that using Mincer returns to measure human capital understates human capital differences across countries by a factor of 2. The cross-country differences in human capital implied by the theory are consistent with evidence from earnings of immigrants in the United States. We also find that TFP has substantial effects on cross-sectional inequality and intergenerational mobility and that public education policies can have important aggregate and distributional implications.
DESIGN OF CMOS RECEIVERS FOR PARALLEL OPTICAL INTERCONNECTS

The growing demand for high-bandwidth communication between integrated circuit chips calls for large numbers of high-speed inputs and outputs (IOs) per chip. IO data rates have increased to the point where electrical signaling is now limited by the channel properties. In order to achieve multi-Gb/s data rates, complex designs that equalize the channel are necessary. Using optics for chip-to-chip interconnections is promising since the optical channel dispersion and cross-talk are small. In this work we demonstrate the possibility of building small and low-power optical receivers that facilitate large numbers of IOs. A new double sampling/integrating front-end is proposed and implemented. Unlike prior designs, this receiver removes the need for a gain stage that runs at the data rate, making it suitable for low-power implementations. This front-end allows a time-division multiplexing technique to support very high data rates. The dynamic range of the integrating input node can be improved by a proposed decision-directed common-mode control loop, which reduces the dependency of the dynamic range on the power supply voltage. The required receive clock can be generated in many ways. While the standard oversampled clock recovery is possible, it needs extra clock phases in the middle of main data samples. In order to reduce the power, a baud rate clock recovery technique is proposed and implemented as part of a transceiver array test-chip. The resulting transceiver consumes less than 150mW per channel at 5.0Gb/s in a 0. 25μm CMOS technology. If projected to a 90nm CMOS technology, 15Gb/s data rate and 30mW power per IO are possible, which allow more than 10Tb/s chip-to-chip bandwidth, with up to one thousand IOs per chip.
A morphology-cosmology connection for X-ray clusters

We employ N-body/three-dimensional gasdynamic simulations of the formation of galaxy clusters to determine whether cluster X-ray morpholgies can be used as cosmological constraints. Confirming the analytic expectations of Richstone, Loeb, & Turner (1992), we demonstrate that cluster evolution is sensitive to the cosmological model in which the clusters form. We further show that evolutionary differences are echoed in the gross morphological features of the cluster X-ray emission
A descriptive study of training and its perceived helpfulness among Illinois sexual assault investigators

ABSTRACT Many sexual assault victims are reluctant to report out of fear of mistreatment by police; others describe the experience of secondary victimization upon reporting. Yet, there is little attention in policy, practice, and research to how investigators are trained to interact with victims and effectively conduct sexual assault investigations. Only recently have sexual assault investigation procedures gained attention with newly enacted legislation to improve the police response to victims; however, the perceived helpfulness of such training is unknown. The present study offers a description of the state of training for sexual assault investigators across Illinois, including the training investigators receive, how beneficial investigators perceive this training to be, and what investigators prioritize as necessary to improve sexual assault investigations. Qualitative and quantitative data reveal investigators’ priorities for training to improve investigations. Implications for future research and training practices are discussed.
Blowup and dissipation in a critical-case unstable thin film equation

We study the dynamics of dissipation and blow-up in a critical-case unstable thin film equation. The governing equation is a nonlinear fourth-order degenerate parabolic PDE derived from a generalized model for lubrication flows of thin viscous fluid layers on solid surfaces. %For a special balance between %destabilizing second-order terms and regularizing fourth-order terms, There is a critical mass for blow-up and a rich set of dynamics including families of similarity solutions for finite-time blow-up and infinite-time spreading. The structure and stability of the steady-states and the compactly-supported similarity solutions is studied.
Applying the Psychology of Working Theory for Transformative Career Education

New models of career education are needed to prepare young people for changes and challenges in the world of work. We propose that the psychology of working framework/theory (PWF/PWT) has the potential to shape career education in transformative ways that are attentive to shifting dimensions of the local context and the marginalization of large segments of the world population in seeking access to decent work. In this article, we present theory and research supporting the PWF/PWT and its application for career development intervention, with specific attention to the constructs of youth purpose and critical consciousness as important resources for coping with massive changes in the world of work and growing inequality. We provide examples of how this might be done, drawing from our current research–practice partnerships that are designing, delivering, and evaluating PWF-/PWT-informed career intervention.
Assessing Usability for Input Operation using Frequency Components of Eye Movements

Dynamic usability-testing is required for the improvement of various Human-Computer interactive systems. This paper examines the indices of assessing usability using the frequency spectrum of eye-movements up to four Hz. An input operational task experiment was conducted using a mouse (Mouse), a keyboard (KeyBD) and a keypad (KeyPAD), and the conventional subjective system usability measurements (SU-scores) and error rates were measured. Most power spectrum densities (PSD) for eye-movements in the first second of the experiment followed the same order of the SU-scores or error rates. Cross spectrum densities (CSD) between horizontal and vertical eye-movements and coherence as standardized CSD also significantly correlate with the results of the SU-scores and error rates. To determine the frequency range of CSD and coherence for usability assessment, frequency components used as factors were extracted using factor analysis. According to the correlation coefficients between these and the performance of factor scores for predicting the conventional metrics, factor scores of CSD can be better indices for assessing usability than can indices of coherence.
“Support is What Really Helped Me Get Through”: Understanding Athletes’ Online Disclosures about Pursuit and Receipt of Social Support During Concussion Recovery

This research examines the role of social support in athletes’ lived experiences with concussion injuries. Fifty-eight blog posts authored by athletes documenting their concussion injuries were analyzed to determine the types of support athletes sought and received while rehabilitating from a concussion. A deductive approach guided by Xu and Burleson’s (2001) social support typology guided analysis of the blog posts. Results indicated that to varying degrees, athletes sought and received emotional, informational, network, esteem, and tangible support. Analysis revealed that athletes experience support deficits with esteem and emotional support, while they appear to have network support needs met. The results enhance understanding of athletes’ lived experiences with concussion symptoms and their support needs as they recovered from this injury. The results also illustrate the types of support that parents, friends, teachers, teammates, coaches, and others can enact to better support athletes through concussion management.
Can Propensity Score Analysis Relplicate estimates based on random evaluations of school choice? a within-study comparison

The ability of propensity score analysis (PSA) to match impact estimates derived from random assignment (RA) is examined using data from the evaluation of two interdistrict magnet schools. As in previous within study comparisons, the estimates provided by PSA and RA differ substantially when PSA is implemented using comparison groups that are not similar to the treatment group and without pretreatment measures of academic performance. Adding pretreatment measures of the performance to the PSA, however, substantially improves the match between PSA and RA estimates. Although the results should not be generalized too readily, they suggest that nonexperimental estimators can, in some circumstances, provide valid estimates of the causal impact of school choice programs.
Mobile and Connected Health Technology Needs for Older Adults Aging in Place: Cross-Sectional Survey Study

Background An increasing number of mobile and wearable devices are available in the market. However, the extent to which these devices can be used to assist older adults to age in place remains unclear. Objective This study aimed to assess older adults’ perceptions of using mobile and connected health technologies. Methods Using a cross-sectional design, a total of 51 participants were recruited from a senior community center. Demographics and usage of mobile or wearable devices and online health communities were collected using a survey questionnaire. Descriptive statistics assessed usage of devices and online health communities. The Fisher exact test was used to examine the relationship between technology usage and having access to a smartphone. Results The sample was primarily comprised non-Hispanic white (35/51, 69%), educated (39/51, 76% any college), and female (36/51, 71%) participants, with an average age of 70 (SD 8) years. All participants were insured and nearly all lived at home (49/51, 94%). A total of 86% (44/51) of the participants had heard of wearable health devices, but only 18 out of 51 (35%) had ever used them. Over 80% (42/51) expressed interest in using such devices and were interested in tracking exercise and physical activity (46/51, 90%), sleep (38/51, 75%), blood pressure (34/51, 67%), diet (31/51, 61%), blood sugar (28/51, 55%), weight (26/51, 51%), and fall risk (23/51, 45%). The greatest concerns about using wearable devices were cost (31/51, 61%), safety (14/51, 28%), and privacy (13/51, 26%); one-fourth (12/51) reported having no concerns. They were mostly interested in sharing data from mobile and connected devices with their health care providers followed by family, online communities, friends, and no one. About 41% (21/51) of the older adults surveyed reported having ever heard of an online health community, and roughly 40% (20/51) of the participants reported being interested in joining such a community. Most participants reported having access to a smartphone (38/51, 74%), and those with such access were significantly more likely to show interest in using a wearable health device (P<.001) and joining an online health community (P=.05). Conclusions Our findings suggest that, although few older adults are currently using mobile and wearable devices and connected health technologies for managing health, they are open to this idea and are mostly interested in sharing such data with their health care providers. Further studies are warranted to explore strategies to balance the data sharing preference of older adults and how to best integrate mobile and wearable device data with clinical workflow for health care providers to promote healthy aging in place.
Modeling program behaviors by hidden Markov models for intrusion detection

Intrusion detection is an important technique in the defense-in-depth network security framework and a hot topic in computer network security in recent years. In this paper, a new efficient intrusion detection method based on hidden Markov models (HMMs) is presented. HMMs are applied to model the normal program behaviors using traces of system calls issued by processes. The output probability of a sequence of system calls is calculated by the normal model built. If the probability of a sequence in a trace is below a certain threshold, the sequence is flagged as a mismatch. If the ratio between the mismatches and all the sequences in a trace exceeds another threshold, the trace is then considered as a possible intrusion. The method is implemented and tested on the sendmail system call data from the University of New Mexico. Experimental results show that the performance of the proposed method in intrusion detection is better than other methods.
IDENTITY DEVELOPMENT OF MIDDLE SCHOOL STUDENTS AS LEARNERS OF SCIENCE AT AN INFORMAL SCIENCE EDUCATION CAMP

Title of Document: IDENTITY DEVELOPMENT OF MIDDLE SCHOOL STUDENTS AS LEARNERS OF SCIENCE AT AN INFORMAL SCIENCE EDUCATION CAMP. Kelly Riedinger Doctor of Philosophy 2011 Directed By: Dr. J. Randy McGinnis Curriculum and Instruction: Science Education researchers and practitioners are increasingly recognizing the need for learning in informal settings to complement formal science learning (Bybee, 2001; Falk, 2001). Informal science education may be critical in meeting the goals of reform and in keeping students and the public informed of advances in science. As such, greater attention has been given to learning in informal science settings. A growing body of research examines how groups engage in learning conversations to make meaning from content and exhibits in these settings. The National Research Council (2009) speculated that individual and group identity might be shaped and reinforced during such learning conversations. The central research question guiding the study was: What is the role of conversation in influencing science learner identity development during an informal science education camp? Identity in this study was defined as becoming and being recognized as a certain type of person (Gee, 2001). This study focused particularly on discursive identity, defined as individual traits recognized through discourse with other individuals (Gee, 2005; 2011). The study used an exploratory case study. Data collection included videotaped observations, researcher field notes, interviews and participants’ reflective journal entries. Each source of data was examined for the conversation that it generated. I used qualitative methods to analyze the data including discourse analysis and the constant comparison method for emergent themes. From the findings of this study, I theorized that the learning conversations played a role in developing participants’ identities as learners of science. Participants used language in the following ways: to make sense of science content, to position themselves, to align their discourse and practices with science, to communicate with others which resulted in engagement, to re-negotiate power, and to see others in new ways. The findings of this research support and extend the research literature on identity, learning conversations in informal science education environments and science camp programs. Implications from this study include recommendations for the design of science camps to support identity development as learners of science for participants. IDENTITY DEVELOPMENT OF MIDDLE SCHOOL STUDENTS AS LEARNERS OF SCIENCE AT AN INFORMAL SCIENCE EDUCATION CAMP
Two populations of progenitors for type ia supernovae

We use recent observations of the evolution of the Type Ia supernova (SN Ia) rate with redshift, the dependence of the SN Ia rate on the colours of the parent galaxies, and the enhancement of the SN Ia rate in radio-loud early-type galaxies to derive on robust empirical grounds, the delay time distribution (DTD) between the formation of the progenitor star and its explosion as an SN. Our analysis finds: (i) delay times as long as 3–4 Gyr, derived from observations of SNe Ia at high redshift, cannot reproduce the dependence of the SN Ia rate on the colours and on the radio-luminosity of the parent galaxies, as observed in the local Universe; (ii) the comparison between observed SN rates and a grid of theoretical ‘single-population’ DTDs shows that only a few of them are possibly consistent with observations. The most successful models are all predicting a peak of SN explosions soon after star formation and an extended tail in the DTD, and can reproduce the data but only at a modest statistical confidence level; (iii) present data are best matched by a bimodal DTD, in which about 50 per cent of SNe Ia (dubbed ‘prompt’ SNe Ia) explode soon after their stellar birth, in a time of the order of 108 yr, while the remaining 50 per cent (‘tardy’ SNe Ia) have a much wider distribution, well described by an exponential function with a decay time of about 3 Gyr. The presence in the DTD of both a strong peak at early times and a prolonged exponential tail, coupled with the well-established bimodal distribution of the decay rate (Δm15) and the systematic difference observed in the expansion velocities of the ejecta of SNe Ia in ellipticals and spirals, suggests the existence of two classes of progenitors. We discuss the cosmological implications of this result and make simple predictions, which are testable with future instrumentation.
Pseudogap induced by short-range spin correlations in a doped Mott insulator

We study the evolution of a Mott-Hubbard insulator into a correlated metal upon doping in the two-dimensional Hubbard model using the cellular dynamical mean-field theory. Short-range spin correlations create two additional bands apart from the familiar Hubbard bands in the spectral function. Even a tiny doping into this insulator causes a jump of the Fermi energy to one of these additional bands and an immediate momentum-dependent suppression of the spectral weight at this Fermi energy. The pseudogap is closely tied to the existence of these bands. This suggests a strong-coupling mechanism that arises from short-range spin correlations and large scattering rates for the pseudogap phenomenon seen in several cuprates.
Photometry of the Type Ia Supernovae 1999cc, 1999cl, and 2000cf

We present previously unpublished BVRI photometry of the Type Ia supernovae 1999cc and 2000cf along with revised photometry of SN 1999cl. We confirm that SN 1999cl is reddened by highly nonstandard dust, with RV = 1.55 ± 0.08. Excepting two quasar-lensing galaxies whose low values of RV are controversial, this is the only known object with a published value of RV less than 2.0. SNe 1999cl and 2000cf have near-infrared absolute magnitudes at maximum in good agreement with other Type Ia supernovae of midrange decline rates.