Miracle-dz/UniFAR-FTUs huggingface dataset:
Enabling new mobile applications with location proofs

Location is rapidly becoming the next "killer application" as location-enabled mobile handheld devices proliferate. One class of applications that has yet-to-emerge are those in which users have an incentive to lie about their location. These applications cannot rely solely on the users' devices to discover and transmit location information because users have an incentive to cheat. Instead, such applications require their users to prove their locations. Unfortunately, today's mobile users lack a mechanism to prove their current or past locations. Consequently, these applications have yet to take off despite their potential. This paper presents location proofs - a simple mechanism that enables the emergence of mobile applications that require "proof" of a user's location. A location proof is a piece of data that certifies a receiver to a geographical location. Location proofs are handed out by the wireless infrastructure (e.g., a Wi-Fi access point or a cell tower) to mobile devices. The relatively short range of the wireless radios ensures that these devices are in physical proximity to the wireless transmitter. As a result, these devices are capable of proving their current or past locations to mobile applications. In this paper, we start by describing a mechanism to implement location proofs. We then present a set of six future applications that require location proofs to enable their core functionality.
Leaders’ Behaviors During Radical Change Processes: Subordinates’ Perceptions of How Well Leader Behaviors Communicate Change

This research asked 252 upper-, middle-, and first-line-level managers in organizations experiencing radical change to assess the effects of their own leaders’ communications and behaviors on their perceptions of the change process. Results indicated that the frequency of exhibition of most behaviors by leaders positively affected subordinates’ perceptions of change. For three types of behaviors, soliciting upward feedback, driving change, and providing resources, the importance of these behaviors to the subordinates’ moderated perceptions of the change process. Discussion of these results and their implications conclude the study.
Pilot studies of in‐course assessment for a revised medical curriculum: II. Computer‐based, individual

PURPOSE: To test a computer-based method of in-course assessment for a modular, systems-oriented medical curriculum at the University of Otago Medical School. METHOD: For the in-course assessment in anatomic pathology, 193 students completed five biweekly (i.e., every two weeks), criterion-referenced, computer-based quizzes incorporating many digitized photographs and a variety of question formats. The students signed up to take quizzes at any of ten available times during each quiz week. A score of 70% was required for passing each quiz, but the students could retake quizzes up to two more times in alternative versions. The students' opinions about biweekly testing and computer-based testing were sought. RESULTS: All 193 students satisfactorily completed the assessment program, with no significant problems with hardware, software, or administration during the more than 1,000 computer-based quizzes. The students valued the bi-weekly quizzes as a stimulus for study and for feedback. They strongly supported computer-based quizzes, identifying a variety of benefits in their responses to the questionnaire. The staff found that development of visually rich quizzes was greatly facilitated by the use of computers. CONCLUSION: The study confirmed the feasibility of using regular, computer-based quizzes for in-course assessment of a large medical school class and demonstrated assessments of a kind that would be difficult to achieve by means other than with computers.
Management of high-grade bone sarcomas over two decades: The Norwegian Radium Hospital experience

All cases of high-grade osteosarcoma (OS) (n = 196) and Ewing's sarcoma of bone (ES) (n = 56) treated at the Norwegian Radium Hospital in the period 1980–1999 were analyzed retrospectively. They were allocated to consecutive ten-year periods by their time of diagnosis. Patient and tumour characteristics have been relatively stable. Eighty percent of all patients received surgical treatment and the amputation rate decreased from 64% to 23%. The percentage of patients receiving chemotherapy has remained around 80%. The use of radiotherapy in primary treatment decreased gradually from 33% to 18%. Sarcoma specific survival (SSS) at five years for all patients increased significantly from 39% to 53%. Similar trends for improvement were seen for both OS and ES. In multivariate analysis, independent prognostic factors for improved SSS were non-metastatic disease at diagnosis, age under 40, extremity tumours, small tumours and treatment from 1995 onwards. No major new treatment options have emerged over these 20 years. The improved outcome appears partly to be due to refinements in the use of existing modalities and improved quality and integration of multidisciplinary approaches. Improved formalized organisation of the sarcoma group and annual audited reports of its patient and research activity may also have contributed to improved focus and performance.
Universal Generator for Complementary Pairs of Sequences Based on Boolean Functions

We present a general algorithm for generating arbitrary standard complementary pairs of sequences (including binary, polyphase, M-PSK and QAM) of length 2^N using Boolean functions. The algorithm follows our earlier paraunitary algorithm, but does not require matrix multiplications. The algorithm can be easily and efficiently implemented in hardware. As a special case, it reduces to the non-recursive (direct) algorithm for generating binary sequences given by Golay, to the algorithm for generating M-PSK sequences given by Davis and Jedwab (and later improved by Paterson) and to all published algorithms for generating QAM sequences. However the algorithm does not solve the problem of sequence uniqueness (except for the trivial M-PSK case), which must be treated separately for each QAM constellation.
Structures of Discoidal High Density Lipoproteins

Conversion of discoidal phospholipid (PL)-rich high density lipoprotein (HDL) to spheroidal cholesteryl ester-rich HDL is a central step in reverse cholesterol transport. A detailed understanding of this process and the atheroprotective role of apolipoprotein A-I (apoA-I) requires knowledge of the structure and dynamics of these various particles. This study, combining computation with experimentation, illuminates structural features of apoA-I allowing it to incorporate varying amounts of PL. Molecular dynamics simulated annealing of PL-rich HDL models containing unesterified cholesterol results in double belt structures with the same general saddle-shaped conformation of both our previous molecular dynamics simulations at 310 K and the x-ray structure of lipid-free apoA-I. Conversion from a discoidal to a saddle-shaped particle involves loss of helicity and formation of loops in opposing antiparallel parts of the double belt. During surface expansion caused by the temperature-jump step, the curved palmitoyloleoylphosphatidylcholine bilayer surfaces approach planarity. Relaxation back into saddle-shaped structures after cool down and equilibration further supports the saddle-shaped particle model. Our kinetic analyses of reconstituted particles demonstrate that PL-rich particles exist in discrete sizes corresponding to local energetic minima. Agreement of experimental and computational determinations of particle size/shape and apoA-I helicity provide additional support for the saddle-shaped particle model. Truncation experiments combined with simulations suggest that the N-terminal proline-rich domain of apoA-I influences the stability of PL-rich HDL particles. We propose that apoA-I incorporates increasing PL in the form of minimal surface bilayers through the incremental unwinding of an initially twisted saddle-shaped apoA-I double belt structure.
Proteoglycans in Human Gliomas Altered Expression and Distribution of Heparan Sulfate Updated Version

The expression of heparan sulfate proteoglycans (HSPGs) by human glioma cells Â»asexamined by biochemical and immunological methods in vitro and in vivo. Chondroitin sulfate was shown to represent the major ['Iljglucosamine-labeled glycosaminoglycan synthesized by cultured nor mal brain cells. However, high-grade glioma-derived cells were shown to express significantly increased quantities of hyaluronic acid and heparan sulfate and approximately equal amounts of chondroitin sulfate compared with normal glial cells. To investigate further the differential expression of HSPGs, proteoglycans were isolated from glioma cells and were used as an immunogen to generate monoclonal antibodies (MAbs). One of these MAbs, 39H (an IgM), was shown to bind more to high-grade glioma-derived cells then to low-grade glioma or normal brain cells in vitro. M \h 39H was also observed to bind to isolated HSPGs but not to heparan sulfate glycosaminoglycan chains or trypsin-treated cells, Immunofluorescence staining of the cultured high-grade glioma cells re vealed an intense diffuse cell surface staining pattern over the entire cell and also isolated footpads. In contrast, the low-grade tumor or normal glial cells showed a distinctive punctated staining. A similar differential staining of M \l> 39H was most prominent between tissue sections of glioblastoma multiforme and anaplastic astrocytomas versus low-grade astrocytomas and normal brain. The low grade gliomas exhibited a weak punctated staining, whereas the high-grade gliomas showed significantly more intense staining, particularly along the apical regions of the cells. These results suggest that altered expression of HSPGs may be related to the malignant transformation or growth potential of glial-derived cells.
Interprofessional Conflict and Repair: A Study of Boundary Work in the Hospital

This article is about boundary work and the accomplishment of work among various groups claiming professional status at the bedside in the hospital. The author analyzes qualitative data from 110 in-depth interviews and participant observation with physicians, nurses, respiratory therapists, social workers, and occupational, physical, and speech therapists. The findings show how work roles, and hence occupational boundaries, are flexible and malleable. Practitioners usually cross these boundaries within reason, and thus boundary work engenders ironic dualities; it generates both conflict and cooperation, questioning and affirmation, and that is why most reasonable work role transgressions do not fundamentally undermine the social order of the hospital. Boundary work provides insights on the dynamic nature of professionalism as the outcome of a negotiated order that reveals itself at the ideological and behavioral levels. Understanding how and why boundary work is done also has policy implications at the workplace and health care service levels.
Measuring Perceived Expressed Emotion of Elderly with Schizophrenia

Environmental factors, including families and staff, have influence on the prognosis of schizophrenic patients. The Theory of Expressed Emotion hypothesizes that patients living with high expressed emotion relatives have higher relapse rate than those living with low expressed emotion relatives. This study measures the patients' perception of expressed emotion of the staff's attitude and to examine the patients' relapse rate. Those patients were elderly with schizophrenia living in a mental rehabilitating setting in the community. In this study, the Chinese level of Expressed Emotion Scale has shown a good reliability. The relapse rate was 15.4 percent for those elderly rated in high Level of Expressed Emotion group and 10 percent for those in low Level of Expressed Emotion group at a one-year follow-up period. The McNemar test has shown that the difference of relapse rate between two groups reached statistical significance. Although health care staffs have received professional training in dealing with psychiatric patients, they are also vulnerable to emotional exhaustion.
Urinary Excretion of Cyanidin Glucosides and Glucuronides in Healthy Humans After Elderberry Juice Ingestion

In a pilot study with 6 females and 1 male, the metabolism of various cyanidin glucosides after oral administration of elderberry juice was investigated. The anthocyanin metabolites were detected in urinary excretion. After ingestion of a bolus quantity of 3.57 g total anthocyanins in a 150 mL elderberry juice concentrate, 0.053% of the administered dose was excreted in urine as glucosidically bound cyanidins within the first 5 hours. Only 0.003% of the ingested anthocyanin glucosides was excreted as cyanidin glucuronide, suggesting that this conversion step might be of minor importance in urinary excretion.
Keeping the Body in Mind

In this short review, we focus on symptoms related to body representation and action awareness in two major Psychiatric Diseases: Anorexia Nervosa and Schizophrenia. First, the neurocognitive processes underlying pathological body image distortion in anorexia nervosa and delusions of alien control in schizophrenia are presented briefly. We then consider the impact of recent research findings on the development of novel forms of therapy for each of the two diseases. Greatest awareness of the latest research on neurocognitive impairments in anorexia nervosa and schizophrenia may help a therapist to better understand a patient’s subjective experience. In turn, this might help the patient to better understand and thus better deal with his/her cognitive symptoms.
The relation between decision time and relative response frequency in a blue-green discrimination.

Using a two-choice blue-green discrimination, decision times were measured for stimuli yielding relative response frequencies of approximately 0.10, 0.50, 0.90 and values close to zero and unity. The results were shown to support the prediction of a so-called accumulator, or recruitment, model of choice. It is also shown that the results could be well accounted for by assuming that the decisions were based on fixed samples of information which vary in quality.
A Meta-Analytic Review of Pretrial Research: Risk Assessment, Bond Type, and Interventions

This study makes an attempt to aggregate what we currently know about pretrial decision making and jurisdictions’ responses to the pretrial population. This meta-analysis began with an exhaustive search for pretrial research which may have revealed the most prominent finding—that being a distinct lack of research that utilizes any amount of methodological rigor. The findings of this meta-analysis hold several policy implications for the field of pretrial research and practice. First, future research studies in the field of pretrial need to focus on methodological quality and rigor. Second, it appears that some conditions of release may be related to a defendant’s likelihood of failure to appear. Third, it appears that none of the conditions of release reviewed in this study are related to a defendant’s likelihood of re-arrest while on pretrial release. Finally, it is recommended that the field of pretrial develop a sound research agenda and execute that plan with rigor, transparency, and an approach that favors the continued cumulation of knowledge. Strong conclusions about the impact of pretrial release conditions cannot be made as the quality of the pretrial research, overall, is weak at best.
Interdependence and Performance: A Natural Experiment in Firm Scope

This paper shows how interdependencies influence performance following a reduction in firm scope. We test the predictions of the theory using detailed microdata on every Peruvian fishing firm before and after a regulatory ban on mackerel fishing, finding that a reduction in the scope of activities causes the productivity of firms’ legacy anchovy operations to fall sharply, before recovering in the long run. The results are most pronounced for firms with the strongest interdependencies between activities. Moreover, we find evidence that the persistence of the productivity decline is explicitly tied to a failure to adapt quickly following the ban. Consistent with our conceptual characterization, the evidence suggests that interdependencies between activities simultaneously create benefits as well as costs, but that costs are more persistent when the firm reduces its scope of activities.
Maintenance model of integrated psychosocial treatment in pediatric bipolar disorder: A pilot feasibility study.

OBJECTIVE The chronic and refractory course of pediatric bipolar disorder merits the study of adjunctive psychosocial interventions designed to facilitate long-term improvements. The objective of this study is to conduct a pilot study of a maintenance model of the child- and family-focused cognitive-behavioral therapy program (CFF-CBT), which comprises psychosocial booster sessions and optimized pharmacotherapy, and to assess whether positive effects seen after the acute phase of treatment could be sustained over time with the use of this model. METHOD The study design was an open trial with the goal of assessing feasibility of such a maintenance model over time. Thirty-four patients 5 to 17 years of age who underwent CFF-CBT were delivered the maintenance model of treatment over a 3-year period and assessed for symptom changes (Children's Global Impressions Scale-Bipolar) and global functioning (Children's Global Assessment Scale). RESULTS Results indicated that participation in the maintenance model of CFF-CBT treatment was associated with positive effects in symptoms and functioning over the 3-year follow-up period. There were no statistically significant differences in postacute-phase treatment scores and scores at years 1, 2, or 3 on any study measures, indicating the maintenance of clinically significant improvements. CONCLUSIONS These findings suggest that maintenance treatment models are feasible and may help facilitate the long-term management of symptoms. Controlled clinical trials that build on this model will help advance treatments for pediatric bipolar disorder toward addressing the low recovery and high relapse rates associated with the disorder.
Skin Penetration and Sun Protection Factor of Five UV Filters: Effect of the Vehicle

To gain information about efficacy and safety of sunscreens, we compared the skin penetration of ultraviolet (UV) filters from two vehicles, i.e. an oil-in-water (O/W) emulsion gel and petrolatum jelly both in vitro and in vivo, as well as the corresponding pharmacological effect, i.e. the sun protection factor (SPF) in vivo. The UV filters studied were benzophenone-3 (BPH), ethylhexyl methoxycinnamate (EHM), butyl methoxydibenzoyl methane, ethylhexyl salicylate and homosalate. The human skin penetration of these five chemicals from the two vehicles was determined both in vitro using Franz cells and in vivo using a standardized tape-stripping method. The SPF of the two sunscreens was determined in vivo following the COLIPA guidelines. In vitro none of the filters permeated through the skin after 6 h of product application and very little could be found in the skin. BPH and EHM were the only UV filters found in the dermis (both after 30 min and 6 h). An effect of the vehicle could be noticed only for BPH after 30 min in the dermis and 6 h in both dermis and epidermis. In vivo, no differences in the amount of individual UV filters (in % of the applied dose) in the 15 first strips of the stratum corneum (SC) were found following 30 min of application of the formulations; however, the amount of UV filters that were retained in the SC was significantly higher (around 3 times) with the O/W emulsion gel than with the petrolatum jelly. This difference between the two vehicles was also of consequence for the SPF in vivo measured 30 min after application of the products (SPF ≅ 18 with the O/W emulsion gel compared to SPF ≅ 10 with the petrolatum jelly). By choosing the right vehicle or optimizing it, not only sunscreen products can be significantly improved in terms of pharmacological efficacy but the potential toxicological risk associated with the skin penetration of UV filters may be significantly reduced.
Maintaining PGC‐1α expression following pressure overload‐induced cardiac hypertrophy preserves angiogenesis but not contractile or mitochondrial function

During pathological hypertrophy, peroxisome proliferator‐activated receptor coactivator 1α (PGC‐1α) is repressed in concert with reduced mitochondrial oxidative capacity and fatty acid oxidation (FAO). We therefore sought to determine if maintaining or increasing PGC‐1α levels in the context of pressure overload hypertrophy (POH) would preserve mitochondrial function and prevent contractile dysfunction. Pathological cardiac hypertrophy was induced using 4 wk of transverse aortic constriction (TAC) in mice overexpressing the human PGC‐1α genomic locus via a bacterial artificial chromosome (TG) and non‐transgenic controls (Cont). PGC‐1α levels were increased by 40% in TG mice and were sustained following TAC. Although TAC‐induced repression of FAO genes and oxidative phosphorylation (oxphos) genes was prevented in TG mice, mitochondrial function and ATP synthesis were equivalently impaired in Cont and TG mice after TAC. Contractile function was also equally impaired in Cont and TG mice following TAC, as demonstrated by decreased +dP/dt and ejection fraction and increased left ventricular developed pressure and end diastolic pressure. Conversely, capillary density was preserved, in concert with increased VEGF expression, while apoptosis and fibrosis were reduced in TG relative to Cont mice after TAC. Hence, sustaining physiological levels of PGC‐1α expression following POH, while preserving myocardial vascularity, does not prevent mitochondrial and contractile dysfunction. —Pereira, R. O. , Wende, A. R. , Crum, A. , Hunter, D. , Olsen, C. D. , Rawlings, T. , Riehle, C. , Ward, W. F. , Abel, E. D. Maintaining PGC‐1α expression following pressure overload‐induced cardiac hypertrophy preserves angiogenesis but not contractile or mitochondrial function. FASEB J. 28, 3691–3702 (2014). www.fasebj. org
Work Stress, Sense of Coherence, and Risk of Type 2 Diabetes in a Prospective Study of Middle-Aged Swedish Men and Women

OBJECTIVE To investigate the prospective influence of work stress on type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS This population-based cohort included 3,205 women and 2,227 men, aged 35–56 years, with baseline normal glucose tolerance measured with oral glucose tolerance test. At follow-up 8–10 years later, T2D was diagnosed in 60 women and 111 men. Work stress factors evaluated by questionnaire (i.e., demands, decision latitude, job strain, shift work, overtime work, and also sense of coherence) were studied in association with T2D. Odds ratios (ORs) and 95% CIs adjusted for age, education, BMI, physical activity, smoking, family history of diabetes, and psychological distress were calculated. RESULTS In women, low decision latitude was associated with T2D on its own (OR 2.4 [95% CI 1.1–5.2]) and combined with high demands: job strain (OR 4.2 [2.0–8.7]), adjusted for all available potential confounders. Also, shift work increased the risk of T2D in women (OR 2.2 [1.0–4.7]) when adjusted for age, education, and psychological distress, although this risk was diluted after multifactor adjustment (OR 1.9 [0.8–4.4]). In men, high work demands and high strain decreased the risk of T2D (OR 0.5 [0.3–0.9]) for both measures, as did an active job (high demands and high decision latitude, OR 0.4 [0.2–0.9]). CONCLUSIONS Work stress and shift work may contribute to the development of T2D in women. In men, the risk was decreased by high work demands, high strain, and an active job.