Miracle-dz/UniFAR-FTUs huggingface dataset:
Reducing 3D wavelet transform execution time through the Streaming SIMD Extensions

This paper focuses on reducing the execution time of the video compression algorithms based on the 3D wavelet transform. We present several optimizations that could not be applied by the compiler due to the characteristics of the algorithm. First, we use the Streaming SIMD Extensions (SSE) for some of the dimensions of the sequence (y and time), in order to reduce the number of floating point instructions, exploiting data level parallelism. Then, we apply loop unrolling and data prefetching to critical parts of the code, and finally the algorithm is vectorized by columns, allowing the use of SIMD instructions for the y dimension. Results show improvements of up to 1.54 over a version compiled with the maximum optimizations of the Intel CIC++ compiler Our experiments also show that, allowing the compiler to perform some of these optimizations (i.e. automatic code vectorization) causes performance slowdown which demonstrates the effectiveness of our optimizations.
Prognosis of Individuals With Asymptomatic Left Ventricular Systolic Dysfunction in the Multi-Ethnic Study of Atherosclerosis (MESA)

Background— Limited data exist on the prevalence, associations, and prognosis of individuals with asymptomatic left ventricular systolic dysfunction (ALVSD), especially in populations without previous clinical cardiovascular disease (CVD). Methods and Results— Kaplan-Meier and Cox proportional hazard analyses were used to assess the association between ALVSD, defined as left ventricular ejection fraction <50%, and adjudicated incident congestive heart failure (CHF), all-cause mortality, and CVD events. Of 5004 participants, 112 participants had CHF, 321 had a CVD event, and 278 died after 9 years of follow-up. The overall prevalence of ALVSD was 1.7%, with a higher prevalence in blacks (2.6%). ALVSD had a worse cardiovascular risk profile and was also associated with increased risk in unadjusted and adjusted models for incident CHF (HR [hazard ratio] [95% CI {confidence interval}]: 12.0 [7.04–20.3], P<0.0001 and 8.69 [4.89–15.45], P<0.001 respectively), CVD (HR [95% CI]: 3.32 [1.98–5.58], P<0.001 and 2.21 [1.30–3.73], P=0.003 respectively), and all-cause mortality (HR [95% CI]: 3.47 [2.03–5.94], P<0.0001 and 2.00 [1.13–3.54], P=0.017, respectively). A 10% decrement in left ventricular ejection fraction at baseline was associated with an increase in risk in unadjusted and adjusted models for clinical CHF (HR [95% CI]: 2.17 [1.82–2.63], P<0.0001 and 2.13 [1.73–2.51], P<0.001, respectively) and all-cause mortality (HR [95% CI]: 1.22 [1.05–1.41], P=0.009 and 1.17 [1.00–1.36], P=0.047, respectively). Among the subset of participants with ALVSD, the left ventricular mass index was particularly informative about risk for incident CHF (c-index=0.74). Conclusions— ALVSD is uncommon in individuals without previous clinical CVD, but it is associated with high risk for CHF, CVD, and all-cause mortality. The left ventricular mass index had good discrimination for incident CHF in Multi-Ethnic Study of Atherosclerosis (MESA) participants with ALVSD.
Tracking and characterizing the head motion of unanaesthetized rats in positron emission tomography

Positron emission tomography (PET) is an important in vivo molecular imaging technique for translational research. Imaging unanaesthetized rats using motion-compensated PET avoids the confounding impact of anaesthetic drugs and enables animals to be imaged during normal or evoked behaviour. However, there is little published data on the nature of rat head motion to inform the design of suitable marker-based motion-tracking set-ups for brain imaging—specifically, set-ups that afford close to uninterrupted tracking. We performed a systematic study of rat head motion parameters for unanaesthetized tube-bound and freely moving rats with a view to designing suitable motion-tracking set-ups in each case. For tube-bound rats, using a single appropriately placed binocular tracker, uninterrupted tracking was possible greater than 95 per cent of the time. For freely moving rats, simulations and measurements of a live subject indicated that two opposed binocular trackers are sufficient (less than 10% interruption to tracking) for a wide variety of behaviour types. We conclude that reliable tracking of head pose can be achieved with marker-based optical-motion-tracking systems for both tube-bound and freely moving rats undergoing PET studies without sedation.
Field measurements of WSD-DTT protection ratios over outdoor and indoor reference geometries

A currently prevalent view of the operation of white space cognitive radios is that they should use geolocation databases to determine their frequency band and maximum transmission power in any given location so that interference radiated to broadcast receivers is negligible. To estimate the level of such interference, physical reference geometries and path loss estimates have been proposed between co-located devices. In this paper we present results of a measurement campaign conducted over indoor and outdoor reference geometry scenarios in a digital terrestrial television test network. Applying a subjective error criterion, we provide practical estimates on the maximum relative transmit powers for white space devices in order to avoid visible interference in television reception. The study applies to various primary and secondary transmission and reception scenarios, and its results can be extended also to estimate protection ratios for signal configurations not considered in the reported measurements.
Therapeutic Hypothermia in Traumatic Brain Injury

Traumatic brain injury (TBI) is a major source of death and severe disability worldwide. In the USA alone, this type of injury causes 290,000 hospital admissions, 51,000 deaths, and 80,000 permanently disabled survivors [1,2]. Intracranial hypertension develops commonly in acute brain injury related to trauma [3,4]. Raised Intracranial pressure (ICP) is an important predictor of mortality in patients with severe TBI, and aggressive treatment of elevated ICP has been shown to reduce mortality and improve outcome [4-11]. Guidelines for the Management of Severe TBI, published in the Journal of Neurotrauma in 2007 [12] make a Level II recommendation that ICP should be monitored in all salvageable patients with a severe TBI (Glasgow Coma Scale [GCS] score of 3–8 after resuscitation) and an abnormal computed tomography (CT) scan. ICP monitoring is also recommended in patients with severe TBI and a normal CT scan if two or more of the following features are noted at admission: age over 40 years, unilateral or bilateral motor posturing, or systolic blood pressure < 90 mm Hg (Level III recommendation). Furthermore, ICP should be maintained less than 20 mmHg and cerebral perfusion pressure (CPP) between 50 and 70 mmHg (Level III).
Ocular Blood Flow Measurements in Healthy White Subjects Using Laser Speckle Flowgraphy

Purpose To assess the feasibility and reliability of Laser Speckle Flowgraphy (LSFG) to measure ocular perfusion in a sample of healthy white subjects and to elucidate the age-dependence of the parameters obtained. Methods This cross-sectional study included 80 eyes of 80 healthy, non-smoking white subjects of Western European descent between 19 and 79 years of age. A commercial LSFG instrument was applied to measure ocular blood flow at the optic nerve head (ONH) three successive times before and after pharmacological pupil dilation. The mean blur rate (MBR), a measure of relative blood flow velocity, was obtained for different regions of the ONH. Eight parameters of ocular perfusion derived from the pulse-waveform analysis of MBR including blowout time (BOT) and falling rate (FR) were also recorded. Results Artifact-free LSFG images meeting the quality criteria for automated image analysis were obtainable in 93.8% without pupil dilation and in 98.8% with pharmacological pupil dilation. Measurements of MBR showed excellent repeatability with intraclass correlation coefficients ≥ 0.937 and were barely affected by pupil dilation. The majority of pulse-waveform derived variables exhibited equally high repeatability. MBR-related blood flow indices exhibited significant age dependence (p<0.001). FR (r = 0.747, p<0.001) and BOT (r = -0.714, p<0.001) most strongly correlated with age. Conclusions LSFG represents a reliable method for the quantitative assessment of ocular blood flow in white subjects. Our data affirms that the LSFG-derived variables FR and BOT may be useful biomarkers for age-related changes in ocular perfusion.
Effects of Exercise on Select Biomarkers and Associated Outcomes in Chronic Pain Conditions

Background: Chronic pain is highly prevalent. Current management is challenged by lack of validated objective measures like biological markers. Clinical pain studies employing exercise interventions have evaluated biomarkers; however, it is unclear how exercise impacts biomarkers involved in pain pathways and whether these markers are associated with relevant pain-related outcomes. This systematic review evaluates data from clinical studies employing exercise interventions in chronic musculoskeletal nonmalignant pain conditions in which biomarkers in pain pathways were measured. Method: Published research studies from several databases were examined using the Jadad Scale for assessing the quality of clinical studies. Results: Twelve research studies were reviewed. Jadad scores ranged from 5 to 11 out of 13 points. Inflammatory markers were most commonly measured followed by neurotransmitter-related genes and metabolite-detecting genes. After exercise interventions, changes in biomarkers involved in neurotransmission and inflammation suggest a hypoalgesic exercise effect. Significant biomarker associations were found with pain intensity, fatigue, depression, anxiety, and quality of life. However, there were varying methodologies in the studies reviewed. Discussion: It remains a question whether biomarkers can be used as objective measures for risk assessment, diagnosis, or evaluation or as surrogate endpoints in chronic pain. Adequate sample sizes, optimal exercise dose determination, study replications, and longitudinal research studies with consistent methodologies are warranted. Regardless, the potential translational value of biomarkers in chronic pain is evident. Advancing nursing research in biomarkers is vital for moving the nursing discipline and clinical chronic pain practice forward. Developing a biobehavioral perspective in chronic pain is also necessary for comprehensive management.
Molecular and Physiological Characterization of Two Novel Multirepeat β-Thymosins from Silkworm, Bombyx mori

β-thymosin plays important roles in the development of the lymphatic system and the central nervous system in vertebrates. However, its role and function in invertebrates remain much less explored. Here, we firstly isolated a gene encoding β-thymosin in silkworm (Bombyx mori L.). Interestingly, this gene encodes two polypeptides, named as BmTHY1 and BmTHY2, via two different modes of RNA splicing. The recombinant proteins fused with an N-term GST tag were over-expressed in Escherichia coli (E. coli) and further purified to near homogenity to prepare mouse antibodies. The Western blot analysis showed that these proteins were expressed in various tissues and organs, as well as in different developmental stages. Amazingly, the expression of BmTHY2 was hugely increased during the pupae stage, indicating a specialized role in this period. The expression of these proteins was gradually decreased in BmN cells infected by BmNPV, suggesting they may play different roles in the virus infection. In addition, both BmTHY1 and BmTHY2 can interact with 14-3-3 of silkworm and Ubiquitin of BmNPV as shown by GST pull down and Co-IP assays, consistent with their roles in the regulation of the development of nervous system.
An experimental and morphometric test of the relationship between vertebral morphology and joint stiffness in Nile crocodiles (Crocodylus niloticus)

Despite their semi-aquatic mode of life, modern crocodylians use a wide range of terrestrial locomotor behaviours, including asymmetrical gaits otherwise only found in mammals. The key to these diverse abilities may lie in the axial skeleton. Correlations between vertebral morphology and both intervertebral joint stiffness and locomotor behaviour have been found in other animals, but the vertebral mechanics of crocodylians have not yet been experimentally and quantitatively tested. We measured the passive mechanics and morphology of the thoracolumbar vertebral column in Crocodylus niloticus in order to validate a method to infer intervertebral joint stiffness based on morphology. Passive stiffness of eight thoracic and lumbar joints was tested in dorsal extension, ventral flexion and mediolateral flexion using cadaveric specimens. Fifteen measurements that we deemed to be potential correlates of stiffness were taken from each vertebra and statistically tested for correlation with joint stiffness. We found that the vertebral column of C. niloticus is stiffer in dorsoventral flexion than in lateral flexion and, in contrast to that of many mammals, shows an increase in joint stiffness in the lumbar region. Our findings suggest that the role of the axial column in crocodylian locomotion may be functionally different from that in mammals, even during analogous gaits. A moderate proportion of variation in joint stiffness (R2=0.279–0.520) was predicted by centrum width and height, neural spine angle and lamina width. These results support the possible utility of some vertebral morphometrics in predicting mechanical properties of the vertebral column in crocodiles, which also should be useful for forming functional hypotheses of axial motion during locomotion in extinct archosaurs.
A seasonal prediction for the wet–cold spells leading to winter crop damage in northwestern Taiwan with a combined empirical–dynamical approach

Winter crop losses from extreme weather in Taiwan have increased in the recent decade, with those losses associated with pronounced wet‐and‐cold events (temperature < 10 °C and precipitation >5 mm day−1). The regional and global patterns of atmospheric circulation and the sea surface temperature (SST) related to the extreme cold that damages fruits, vegetables, and paddy rice in northwest Taiwan were investigated. Cool SST anomalies in the western North Pacific (WNP) and warm SST in the central‐eastern Pacific associated with the Pacific meridional mode (PMM) shared a significant role in the occurrence of wet‐and‐cold events in northwest Taiwan. The interactions of the WNP/PMM with the North Pacific Oscillation (NPO) and the Central Pacific type of El Niño led to a pronounced lead–lag relationship with the occurrence of wet‐and‐cold events. An empirical model was subsequently developed to predict the wet‐and‐cold event frequency using observed values of WNP, Niño‐3.4, and Arctic Oscillation from year‐1 and predicted indices of WNP and PMM derived from the Climate Forecast System Version 2 (CFSv2) outputs. The predictive skill of this hybrid empirical–dynamical model was statistically significant throughout the 6 months leading up to the occurrence of wet‐and‐cold events.
Forty Years of Climate and Land-Cover Change and its Effects on Tourism Resources in Kilimanjaro National Park

ABSTRACT This study explores the effects of observed changes in rainfall, temperature and land cover on the physical and sightseeing aspects of trekking in Kilimanjaro National Park. The impact analysis is organised around hazard-activity pairs approach, combinations of environmental change aspects (such as higher temperatures) and tourism activities (such as trekking and sightseeing). The results suggest that higher temperatures and reduced rainfall have lowered the risks of landslides, rock fall and mountain sickness, improving physical trekking conditions. Changes in land cover have affected sightseeing: there now are more flowers and groundsels to admire and less wildlife, waterfalls and snow. In the short term, the disappearing snow may give rise to “last chance tourism”, increasing visitation, but eventually, the loss of snow and forest cover will likely decrease the number of tourists. The paper concludes that effective management of the attractions in the expanding heathlands is the most promising option to limit the losses.
Effect of benzene extract of Ocimum sanctum leaves on cauda epididymal spermatozoa of rats

Background: Recent studies have shown that benzene extract of Ocimum sanctum (O. sanctum) leaves induces the ultrastructural changes in the epithelial cells of the cauda epididymis, its subsequent recovery in the seminiferous epithelium and fertility of male albino rats. Objective: Our aim was to investigate the effect of benzene extract of O.sanctum leaves on the cauda epididymal sperm parameters, morphology and their organelles at the ultrastructural level in albino rats. Materials and Methods: Wistar male rats (n=20) were allocated into two groups of control (n=10) and test group (n=10). The test group received benzene extract of O.sanctum leaves (250mg/kg/day) for 48 consequence days. Five animals from each group were used for fertility test. Twenty-four hours after the last dose, the rest of the control (n=5) and treated (n=5) animals were sacrificed by cervical dislocation and then the cauda epididymal plasma was used for sperm analysis, scanning electron microscopy (SEM) and transmission electron microscopic (TEM) studies. Results: Sperm analysis of test group exhibited significant (p≤0.001) decrease in the sperm count, motility, speed and increase in sperm anomalies when compare to control group. SEM and TEM observation in treated animals indicated the morphological changes in plasma membrane as well as in the acrosomal membrane of spermatozoa, formation of a balloon-like cytoplasmic droplet in the mid-region of abnormal tail and disorganization or degeneration of mitochondria of sperm mitochondrial sheaths. Conclusion: The effects observed in this study may have resulted from a general alteration in the cauda epididymal milieu, probably due to androgen deficiency consequent to the anti-androgenic property of O.sanctum leaves.
Efficient Algorithms for Zeckendorf Arithmetic

We study the problem of addition and subtraction using the Zeckendorf representation of integers. We show that both operations can be performed in linear time; in fact they can be performed by combinational logic networks with linear size and logarithmic depth. The implications of these results for multiplication, division and square-root extraction are also discussed.
A compositional origin to ultralow‐velocity zones

We analyzed vertical component short‐period ScP waveforms for 26 earthquakes occurring in the Tonga‐Fiji trench recorded at the Alice Springs Array in central Australia. These waveforms show strong precursory and postcursory seismic arrivals consistent with ultralow‐velocity zone (ULVZ) layering beneath the Coral Sea. We used the Viterbi sparse spike detection method to measure differential travel times and amplitudes of the postcursor arrival ScSP and the precursor arrival SPcP relative to ScP. We compare our measurements to a database of 340,000 synthetic seismograms finding that these data are best fit by a ULVZ model with an S wave velocity reduction of 24%, a P wave velocity reduction of 23%, a thickness of 8.5 km, and a density increase of 6%. This 1:1 VS:VP velocity decrease is commensurate with a ULVZ compositional origin and is most consistent with highly iron enriched ferropericlase.
Simulation based cause and effect analysis of cycle time distribution in semiconductor backend

We analyzed the effect of a number of controllable input parameters on cycle time distribution and other output variables in a complex semiconductor backend manufacturing system, using a data driven, discrete event simulation model. A validated model was used as the base case and the effects were quantified against the base model to analyze the relative merits and sensitivity of each of these input variables. Input variables that are analyzed include lot release controls, heuristic scheduling rules, machine up time, setup time, material handling time, product flow, and lot size. We have used actual data from a major semiconductor backend site for our analysis and showed the impact of lot release scheduling on cycle time distribution.
Long-Term Performance of Cochlear Implants in Postlingually Deafened Adults

Objective To evaluate the stability of long-term hearing performance after cochlear implantation (CI) in postlingually deafened adults and to explore the boundaries and limitations of the present test batteries for adult CI patients. Study Design Case series with chart review. Setting Tertiary referral center. Subjects and Methods A cohort of 1005 postlingually deafened adult cochlear implantees, who received their implants after age 18 years, was unilaterally implanted and had no inner ear malformations or cochlear ossification. Hearing performance with cochlear implant was evaluated with the help of 5 standard German speech tests. Results The average performance improved significantly during the first 6 months in all tests (learning phase) and afterward entered a plateau phase in which no statistically significant improvements or deteriorations were observed for more than 20 years of follow-up. For each test, the average performance of the cohort, the ceiling effect, and the average results for high and low performers are presented. Conclusions In this study, postlingually deafened adults required about 6 months to learn how to process the artificial signals delivered by the cochlear implant. After this learning phase, the hearing performance entered a stable plateau phase for more than 20 years. This stability reveals the long-term reliability of the technology and the biological stability of the electrode-nerve interface over years. In this study, the authors also evaluated the “ceiling effect” with 5 standard German speech tests, used for evaluation of postlingually deafened adult CI patients.
Four Small Universal Turing Machines

We present universal Turing machines with state-symbol pairs of (5, 5), (6, 4), (9, 3) and (15, 2). These machines simulate our new variant of tag system, the bi-tag system and are the smallest known single-tape universal Turing machines with 5, 4, 3 and 2-symbols, respectively. Our 5-symbolmachine uses the same number of instructions (22) as the smallest known universal Turing machine by Rogozhin. Also, all of the universalmachines we present here simulate Turing machines in polynomial time.
Effect of Robotic-Assisted Gait Training in Patients With Incomplete Spinal Cord Injury

Objective To determine the effect of robotic-assisted gait training (RAGT) compared to conventional overground training. Methods Sixty patients with motor incomplete spinal cord injury (SCI) were included in a prospective, randomized clinical trial by comparing RAGT to conventional overground training. The RAGT group received RAGT three sessions per week at duration of 40 minutes with regular physiotherapy in 4 weeks. The conventional group underwent regular physiotherapy twice a day, 5 times a week. Main outcomes were lower extremity motor score of American Spinal Injury Association impairment scale (LEMS), ambulatory motor index (AMI), Spinal Cord Independence Measure III mobility section (SCIM3-M), and walking index for spinal cord injury version II (WISCI-II) scale. Results At the end of rehabilitation, both groups showed significant improvement in LEMS, AMI, SCIM3-M, and WISCI-II. Based on WISCI-II, statistically significant improvement was observed in the RAGT group. For the remaining variables, no difference was found. Conclusion RAGT combined with conventional physiotherapy could yield more improvement in ambulatory function than conventional therapy alone. RAGT should be considered as one additional tool to provide neuromuscular reeducation in patient with incomplete SCI.