Miracle-dz/UniFAR-FTUs huggingface dataset:
Eurographics Symposium on Geometry Processing (2005) an Adaptive Mls Surface for Reconstruction with Guarantees

Recent work have shown that moving least squares (MLS) surfaces can be used effectively to reconstruct surfaces from possibly noisy point cloud data. Several variants of MLS surfaces have been suggested, some of which have been analyzed theoretically for guarantees. These analyses, so far, have assumed uniform sampling density. We propose a new variant of the MLS surface that, for the first time, incorporates local feature sizes in its formulation, and we analyze it for reconstruction guarantees using a non-uniform sampling density. The proposed variant of the MLS surface has several computational advantages over existing MLS methods.
Chern numbers of the Chern submanifolds

We solve the generalized Milnor–Hirzebruch problem on the relations between Chern numbers of an arbitrary stably almost complex manifold and Chern numbers of its virtual Chern submanifolds. As a corollary we derive new divisibility conditions for Chern classes of an arbitrary complex vector bundle over a stably almost complex manifold.
THE AGE AND RELATIONSHIPS OF THE MAJOR ANIMAL PHYLA

Given the uncertainties in the fossil record and the paucity of informative morphological characters, there is still considerable uncertainty as to the phylogenetic affinities and times of origins of essentially all of the phyla of animals. A multilocus analysis of amino‐acid sequence data for mitochondrial genes suggests that the major triploblast phyla began diverging approximately 630 million years ago. These results support the hypothesis that the so‐called Cambrian radiation of animals actually initiated about 100 million years prior to the Cambrian, as the fossil evidence suggests. In addition, phylogenetic analysis supports the monophyly of animals, an early (~900 million years ago) branching off of the cnidarian lineage, the monophyly of deuterostomes and protostomes, and the inclusion of nematodes in the protostome lineage. The results of this study suggest that, with appropriate levels of taxon sampling and a focus on conserved regions of protein‐coding sequence, complete mitochondrial genome analysis may be sufficiently powerful to elucidate the genealogical relationships of many of the animal phyla.
User Modeling in Language Learning with Macaronic Texts

Foreign language learners can acquire new vocabulary by using cognate and context clues when reading. To measure such incidental comprehension, we devise an experimental framework that involves reading mixed-language “macaronic” sentences. Using data collected via Amazon Mechanical Turk, we train a graphical model to simulate a human subject’s comprehension of foreign words, based on cognate clues (edit distance to an English word), context clues (pointwise mutual information), and prior exposure. Our model does a reasonable job at predicting which words a user will be able to understand, which should facilitate the automatic construction of comprehensible text for personalized foreign language education.
Natural Language Generation in Dialog Systems

Recent advances in Automatic Speech Recognition technology have put the goal of naturally sounding dialog systems within reach. However, the improved speech recognition has brought to light a new problem: as dialog systems understand more of what the user tells them, they need to be more sophisticated at responding to the user. The issue of system response to users has been extensively studied by the natural language generation community, though rarely in the context of dialog systems. We show how research in generation can be adapted to dialog systems, and how the high cost of hand-crafting knowledge-based generation systems can be overcome by employing machine learning techniques.
An Interpretative Phenomenological Analysis of Participation in a Pro-anorexia Internet Site and Its Relationship with Disordered Eating

Pro-anorexia Internet sites aim to promote, support and discuss anorexia nervosa. Media coverage has raised concerns that sites may increase the level of eating disorders. This research examines the meaning of participation in a pro-anorexia Internet site and its relationship with disordered eating by using an interpretative phenomenological analysis of fifteen separate message ‘threads’ followed over a six-week period. Four themes were identified: (1) tips and techniques; (2) ‘ana’ v. anorexia nervosa; (3) social support; and (4) need for anorexia. Findings suggest participation was multi-purpose, providing a coping function in relation to weight loss, and the contribution of sites to increased levels of eating disorders is not inevitable.
The fat-pyramid: a robust network for parallel computation

This paper shows that a fat-pyramid of area Θ( A ) built from processors of size lg A requires only O (lg 2 A ) slowdown in bit-times to simulate any network of area A under very general conditions. Speciﬁcally, there is no restriction on processor size (amount of attached memory) or number of processors in the competing network, nor is the assumption of unit wire delay required. This paper also derives upper bounds on the slowdown required by a fat-pyramid to simulate a network of larger area in the case of unit wire delay.
Palatal evaluation and treatment in 22q11.2 deletion syndrome

Palatal involvement occurs commonly in patients with 22q11.2 Deletion Syndrome (22qDS), and includes palatal clefting and velopharyngeal dysfunction in the absence of overt or submucous clefts. The reported incidence and distribution of palatal abnormalities vary in the literature. The aim of this article is to revisit the incidence and presenting features of palatal abnormalities in a large cohort of patients with 22qDS, summarize the surgical treatments performed in this cohort, and provide an overview of surgical treatment protocols and management guidelines for palatal abnormalities in this syndrome. Charts of 1,121 patients seen through the 22q and You Center at the Children's Hospital of Philadelphia were reviewed for palatal status, demographic factors, deletion size, and corrective surgical procedures. Statistical analysis was performed using Pearson's chi‐squared test to identify differences between gender, deletion size, and palatal abnormality. Of the patients with complete evaluations, 67% were found to have a palatal abnormality. The most common finding was velopharyngeal dysfunction in 55.2% of patients, and in 33.3% of patients, this occurred in the absence of palatal clefting. There was no significant difference in the incidence of palatal abnormalities by gender; however, a difference was noted among race (p < 0.01) and deletion sizes (p < 0.01). For example, Caucasian and Asian patients presented with a much higher prevalence of palatal abnormalities, and conversely those with nested deletions presented with a much lower rate of palatal defects. Overall, 26.9% of patients underwent palatal surgery, and the most common indication was velopharyngeal dysfunction. Palatal abnormalities are a hallmark feature of 22q11.2 Deletion Syndrome; understanding the incidence, presenting features, and treatment protocols are essential for practitioners counseling and treating families affected with this disorder.
Wound Fluid in Diabetic Foot Ulceration

Valid and reproducible sampling techniques as well as processing protocols are required for the assessment of biomarkers and mediators contained in wound exudate. Moreover, the ideal technique should be easy to use even in daily clinical routine. This is challenging since wound fluid represents an inhomogeneous mixture of different exogenous and endogenous sources. Analyzing wound fluid, however, may facilitate clinical decision making. Many techniques for obtaining wound fluid have been described. There is very little validation data, and the array of different techniques appears confusing. Structuring and new standards are needed to avoid wound fluid sampling yielding an “undefined soup. ” A lot of wound fluid parameters have been analyzed, although none of them have made its way into clinical practice. Nevertheless, basic principles of wound healing have been established from wound fluid analysis. With adequate techniques suitable for daily practice, basic research might foster our clinical understanding of wound healing with implications for new therapies. So far, research has mainly concentrated on analyzing available sample material with respect to either a wide variety of analytes or comparing acute with chronic wound exudate. Clinical endpoints such as healing or wound infection as well as longitudinal data may indeed be more valuable for clinical practice, enabling the discovery of meaningful biomarkers using a suitable technique.
Quasi-potential landscape in complex multi-stable systems

The developmental dynamics of multicellular organisms is a process that takes place in a multi-stable system in which each attractor state represents a cell type, and attractor transitions correspond to cell differentiation paths. This new understanding has revived the idea of a quasi-potential landscape, first proposed by Waddington as a metaphor. To describe development, one is interested in the ‘relative stabilities’ of N attractors (N > 2). Existing theories of state transition between local minima on some potential landscape deal with the exit part in the transition between two attractors in pair-attractor systems but do not offer the notion of a global potential function that relates more than two attractors to each other. Several ad hoc methods have been used in systems biology to compute a landscape in non-gradient systems, such as gene regulatory networks. Here we present an overview of currently available methods, discuss their limitations and propose a new decomposition of vector fields that permits the computation of a quasi-potential function that is equivalent to the Freidlin–Wentzell potential but is not limited to two attractors. Several examples of decomposition are given, and the significance of such a quasi-potential function is discussed.
Mobile phone web browsing: a study on usage and usability of the mobile web

Browsing the Web on mobile phones has finally hit the mass. The visualization of websites on latest mobile phone models comes close to what we are used from desktop computers. Tailoring websites for mobile phones seems to be not mandatory anymore. But still the small display size limits the user experience when browsing the web on these devices. As a result although access to the full web is reasonably well working a tendency to providing additional versions of mobile optimized versions of websites can be observed. This paper presents a multidimensional study where usage scenarios as well as the usability of mobile tailored compared to full websites were investigated. The results show clearly that users prefer and effectively do benefit from mobile optimized versions. However content providers sometimes do not understand the mobile scenarios in which their sites are used and consequently begin optimizing the functionality at the wrong end.
In vitro proton T1 and T2 studies on rat liver: Analysis of multiexponential relaxation processes

At 37°C and 20 MHz, the T1 and T2 proton relaxation processes in intact rat liver tissue are multiexponential functions which in the majority of cases were decomposed into a major (α* ≈ 90%, T 1* = 374 ms, T 2* = 58 ms) and a minor (α** ≈ 10%, T 1** = 130 ms, T 2** = 181 ms) component. Both, T1 and T2, are temperature‐dependent with a temperature shift of ΔT1 = 1.5 ms/°C and ΔT2 = 0.5 ms/°C, respectively. Storage of liver tissue at 4°C and 37°C led to remarkable changes of the T1 and T2 values. For T2 these changes occurred after a shorter storage time than for T1, but they are more pronounced for T1, To avoid such influences the relaxation measurements were performed within one hour after excision of the tissue. Even at 4°C, long‐term storage (>3h) must be avoided. A method for the quantitative determination of the fat content in liver based on multiexponential analysis of the T1 relaxation process was evaluated employing mixtures of triolein with liver homogenate. Triolein is a two‐component system with T 1* = 144 ms (α* = 62%) and T 1** = 355 ms (α** = 38%). Finally, liver‐specific protocol conditions were defined for in vitro relaxation studies. © 1986 Academic Press, Inc.
A model for obesity and gigantism due to disruption of the Ankrd26 gene

Obesity is a major health hazard that is caused by a combination of genetic and behavioral factors. Several models of obesity have been described in mice that have defects in the production of peptide hormones, in the function of cell membrane receptors, or in a transcription factor required for neuronal cell development. We have been investigating the function of a family of genes (POTE and ANKRD26) that encode proteins that are associated with the inner aspect of the cell membrane and that contain both ankyrin repeats and spectrin helices, motifs known to interact with signaling proteins in the cell. To assess the function of ANKRD26, we prepared a mutant mouse with partial inactivation of the Ankrd26 gene. We find that the homozygous mutant mice develop extreme obesity, insulin resistance, and an increase in body size. The obesity is associated with hyperphagia with no reduction in energy expenditure and activity. The Ankrd26 protein is expressed in the arcuate and ventromedial nuclei within the hypothalamus and in the ependyma and the circumventricular organs that act as an interface between the peripheral circulation and the brain. In the enlarged hearts of the mutant mice, the levels of both phospho-Akt and mTOR were elevated. These results show that alterations in an unidentified gene can lead to obesity and identify a molecular target for the treatment of obesity.
X-ray variability of GRS 1915+105 during the low-hard state observed with the Indian X-ray astronomy experiment (IXAE)

The galactic superluminal transient X-ray source GRS 1915+105 was observed with the pointed proportional counters (PPCs) onboard the Indian satellite IRS-P3 during 1996 July 23-27. We report here details of the behavior of this source during the relatively quiet and low luminosity state. Large intensity variations by a factor of 2 to 3, generally seen in black-hole candidates, are observed at a time scale of 100 ms to few seconds. No significant variation is detected over larger time scale of minute or more. The intensity variations are described as sum of shots in the light curve, and the number distribution of the shots are found to be exponential function of the fluence and duration of the shots. The cross correlation spectrum between 6-18 keV and 2-6 keV X-rays is found to have asymmetry signifying a delay of the hard X-rays by about 0.2 to 0.4 sec. This supports the idea of hard X-rays being generated by Compton up-scattering from high energy clouds near the source of soft X-rays. Very strong and narrow quasi periodic oscillations in the frequency range 0.62 to 0.82 Hz are observed. We discuss about a model which explains a gradual change in the QPO frequencies with corresponding changes in the mass accretion rate of the disk.
General Stochastic Networks for Classification

We extend generative stochastic networks to supervised learning of representations. In particular, we introduce a hybrid training objective considering a generative and discriminative cost function governed by a trade-off parameter λ. We use a new variant of network training involving noise injection, i.e. walkback training, to jointly optimize multiple network layers. Neither additional regularization constraints, such as l1, l2 norms or dropout variants, nor pooling- or convolutional layers were added. Nevertheless, we are able to obtain state-of-the-art performance on the MNIST dataset, without using permutation invariant digits and outperform baseline models on sub-variants of the MNIST and rectangles dataset significantly.
Are activity promotion interventions based on the transtheoretical model effective? A critical review

The health benefits of physical activity are well documented yet 70% of adults remain sedentary. It has been suggested that inverventions based on the transtheoretical model of behaviour change (TTM) may be useful in promoting physical activity. Published work on the effectiveness of such inteventions is therefore critically reviewed. Although there is evidence that TTM based activity promotion interventions are effective in promoting activity adoption, initial results on longer term adherence are disappointing.
Identification and characterization of RET fusions in advanced colorectal cancer

There is an unmet clinical need for molecularly directed therapies available for metastatic colorectal cancer. Comprehensive genomic profiling has the potential to identify actionable genomic alterations in colorectal cancer. Through comprehensive genomic profiling we prospectively identified 6 RET fusion kinases, including two novel fusions of CCDC6-RET and NCOA4-RET, in metastatic colorectal cancer (CRC) patients. RET fusion kinases represent a novel class of oncogenic driver in CRC and occurred at a 0.2% frequency without concurrent driver mutations, including KRAS, NRAS, BRAF, PIK3CA or other fusion tyrosine kinases. Multiple RET kinase inhibitors were cytotoxic to RET fusion kinase positive cancer cells and not RET fusion kinase negative CRC cells. The presence of a RET fusion kinase may identify a subset of metastatic CRC patients with a high response rate to RET kinase inhibition. This is the first characterization of RET fusions in CRC patients and highlights the therapeutic significance of prospective comprehensive genomic profiling in advanced CRC.
Evaluating Information Sharing Strategies in Supply Chains

This paper evaluates the impact of information sharing strategies on the performance of a supply chain. We consider three forms of information sharing strategies: (1) order information sharing where every stage of the supply chain only knows the orders from its immediate downstream stage; (2) demand information sharing where every stage has full information about the market demand; (3) inventory information sharing where each stage shares its inventory levels and demand information with its immediate upstream stage. Our results indicate that information sharing improves supply chain performance when demand is relatively stable. More importantly, we find that a hybrid information sharing strategy, which uses demand information sharing in the distribution network of the supply chain while using inventory information sharing in the supplier network, is the ideal strategy to improve supply chain performance when demand mix is volatile.
Management of minor illness.

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Multiple hypothalamic cell populations encoding distinct visual information

Non‐technical summary A retinal projection to a brain ‘clock’ in the suprachiasmatic nuclei (SCN) and various other hypothalamic regions allows light to regulate many aspects of physiology and behaviour. The exact nature of light‐evoked responses in these hypothalamic regions and the degree to which they rely upon the various classes of retinal photoreceptor is incompletely understood. Multielectrode recordings in the mouse hypothalamus reveal four classes of visually responsive neuron whose activity is altered by changes in illumination (contrast) and/or according to steady‐state light levels (irradiance). These cells appear in different locations and vary in their daily profile of electrical activity. The properties of one class suggest a direct association with regulating the SCN clock, while the others appear suited to provide more direct modulations in physiology and behaviour. Together, these findings establish a framework for understanding how light regulates such a diverse array of body systems.
Maximizing the Potential of Young Adults with Visual Impairments: The Metacognitive Element

An intervention project at the Hebrew University Learning Center for the Blind introduced metacognitive techniques to compensate for educational deficiencies in visually impaired young adults with a history of academic failure. The project, based on the Instrumental Enrichment cognitive training program, led to improvement in students’ motivation, awareness of their own learning strategies, more rapid and sustained academic progress, and increased autonomy in learning.
Material Gain Analysis of GeSn/SiGeSn Quantum Wells for Mid-Infrared Si-Based Light Sources Based on Many-Body Theory

Material gain of GeSn/SiGeSn quantum wells, which can be grown on Si substrate using a buffer layer, is analyzed based on microscopic many-body theory (MBT) for mid-infrared light sources based on Si photonics. MBT can consider a gain spectrum broadening associated with scattering phenomena, such as Coulomb scattering, based on quantum field theory, and does not need any artificial fitting parameters, such as a relaxation time, used in conventional analysis. Not only rbut also carrier distributions in L-points are considered for the gain analysis. Using MBT, the quantum well structures maximizing the material gain and the differential gain at the threshold are investigated in terms of the well thickness, the strain, and the energy difference of quantum states between rand L-points.