Miracle-dz/UniFAR-FTUs huggingface dataset:
Deep Convolutional AutoEncoder-based Lossy Image Compression

Image compression has been investigated as a fundamental research topic for many decades. Recently, deep learning has achieved great success in many computer vision tasks, and is gradually being used in image compression. In this paper, we present a lossy image compression architecture, which utilizes the advantages of convolutional autoencoder (CAE) to achieve a high coding efficiency. First, we design a novel CAE architecture to replace the conventional transforms and train this CAE using a rate-distortion loss function. Second, to generate a more energy-compact representation, we utilize the principal components analysis (PCA) to rotate the feature maps produced by the CAE, and then apply the quantization and entropy coder to generate the codes. Experimental results demonstrate that our method outperforms traditional image coding algorithms, by achieving a 13.7% BD-rate decrement on the Kodak database images compared to JPEG2000. Besides, our method maintains a moderate complexity similar to JPEG2000.
Connectors meet Choreographies

We present Cho-Reo-graphies (CR), a new language model that unites two powerful programming paradigms for concurrent software based on communicating processes: Choreographic Programming and Exogenous Coordination. In CR, programmers specify the desired communications among processes using a choreography, and define how communications should be concretely animated by connectors given as constraint automata (e.g., synchronous barriers and asynchronous multi-casts). CR is the first choreography calculus where different communication semantics (determined by connectors) can be freely mixed; since connectors are user-defined, CR also supports many communication semantics that were previously unavailable for choreographies. We develop a static analysis that guarantees that a choreography in CR and its user-defined connectors are compatible, define a compiler from choreographies to a process calculus based on connectors, and prove that compatibility guarantees deadlock-freedom of the compiled process implementations.
Temperature effects on ballistic prey capture by a dragonfly larva

Abstract Understanding the effects of temperature on prey–predator interactions is a key issue to predict the response of natural communities to climate change. Higher temperatures are expected to induce an increase in predation rates. However, little is known on how temperature influences close‐range encounter of prey–predator interactions, such as predator's attack velocities. Based on the speed–accuracy trade‐off concept, we hypothesized that the increase in predator attack velocity by increasing temperature reduces the accuracy of the attack, leading to a lower probability of capture. We tested this hypothesis on the dragonfly larvae Anax imperator and the zooplankton prey Daphnia magna. The prey–predator encounters were video‐recorded at high speed, and at three different temperatures. Overall, we found that (1) temperature had a strong effect on predator's attack velocities, (2) prey did not have the opportunity to move and/or escape due to the high velocity of the predator during the attack, and (3) neither velocity nor temperature had significant effects on the capture success. By contrast, the capture success mainly depended on the accuracy of the predator in capturing the prey. We found that (4) some 40% of mistakes were undershooting and some 60% aimed below or above the target. No lateral mistake was observed. These results did not support the speed–accuracy trade‐off hypothesis. Further studies on dragonfly larvae with different morphological labial masks and speeds of attacks, as well as on prey with different escape strategies, would provide new insights into the response to environmental changes in prey–predator interactions.
Estimating the timing of early eukaryotic diversification with multigene molecular clocks

Although macroscopic plants, animals, and fungi are the most familiar eukaryotes, the bulk of eukaryotic diversity is microbial. Elucidating the timing of diversification among the more than 70 lineages is key to understanding the evolution of eukaryotes. Here, we use taxon-rich multigene data combined with diverse fossils and a relaxed molecular clock framework to estimate the timing of the last common ancestor of extant eukaryotes and the divergence of major clades. Overall, these analyses suggest that the last common ancestor lived between 1866 and 1679 Ma, consistent with the earliest microfossils interpreted with confidence as eukaryotic. During this interval, the Earth's surface differed markedly from today; for example, the oceans were incompletely ventilated, with ferruginous and, after about 1800 Ma, sulfidic water masses commonly lying beneath moderately oxygenated surface waters. Our time estimates also indicate that the major clades of eukaryotes diverged before 1000 Ma, with most or all probably diverging before 1200 Ma. Fossils, however, suggest that diversity within major extant clades expanded later, beginning about 800 Ma, when the oceans began their transition to a more modern chemical state. In combination, paleontological and molecular approaches indicate that long stems preceded diversification in the major eukaryotic lineages.
Recurrent Entity Networks with Delayed Memory Update for Targeted Aspect-Based Sentiment Analysis

While neural networks have been shown to achieve impressive results for sentence-level sentiment analysis, targeted aspect-based sentiment analysis (TABSA) — extraction of fine-grained opinion polarity w.r. t. a pre-defined set of aspects — remains a difficult task. Motivated by recent advances in memory-augmented models for machine reading, we propose a novel architecture, utilising external “memory chains” with a delayed memory update mechanism to track entities. On a TABSA task, the proposed model demonstrates substantial improvements over state-of-the-art approaches, including those using external knowledge bases.
PD-L1 expression in medulloblastoma: an evaluation by subgroup

Background This study evaluated the expression of PD-L1 and markers of immune mediated resistance in human medulloblastoma (MB), the most common malignant pediatric brain tumor. Results Overall levels of PD-L1 in human MB were low; however, some cases demonstrated robust focal expression associated with increased immune infiltrates. The case with highest PD-L1 expression was a sonic hedgehog (SHH) MB. In cell lines, SHH MB, which are low-MYC expressing, demonstrated both constitutive and inducible expression of PD-L1 while those in Group 3/4 that expressed high levels of MYC had only inducible expression. In vitro, IFN-γ robustly stimulated the expression of PD-L1 in all cell lines while radiation induced variable expression. Forced high MYC expression did not significantly alter PD-L1. Methods Human MB tumor samples were evaluated for expression of PD-L1 and immune cell markers in relation to molecular subgroup assignment. PD-L1 expression was functionally analyzed under conditions of interferon gamma (IFN-γ), radiation, and MYC overexpression. Conclusions MB expresses low levels of PD-L1 facilitating immune escape. Importantly, TH1 cytokine stimulation appears to be the most potent inducer of PD-L1 expression in vitro suggesting that an inflamed tumor microenvironment is necessary for PD-1 pathway activation in this tumor.
Understanding and addressing mathematics anxiety using perspectives from education, psychology and neuroscience

Mathematics anxiety is a significant barrier to mathematical learning. In this article, we propose that state or on-task mathematics anxiety impacts on performance, while trait mathematics anxiety leads to the avoidance of courses and careers involving mathematics. We also demonstrate that integrating perspectives from education, psychology and neuroscience contributes to a greater understanding of mathematics anxiety in its state and trait forms. Research from cognitive psychology and neuroscience illustrates the effect of state mathematics anxiety on performance and research from cognitive, social and clinical psychology, and education can be used to conceptualise the origins of trait mathematics anxiety and its impact on avoidant behaviour. We also show that using this transdisciplinary framework to consider state and trait mathematics anxiety separately makes it possible to identify strategies to reduce the negative effects of mathematics anxiety. Implementation of these strategies among particularly vulnerable groups, such as pre-service teachers, could be beneficial.
Peran Guru Bimbingan Konseling dalam Membina Kecerdasan Emosional dan Spiritual Siswa Berkebutuhan Khusus

The background of this research is the need for Students with Special Needs (SBK) in SMP PGRI will Pity the extra handling of teacher Counseling (BK) in the development of Emotional and Spiritual Intelligence (ESQ). The results showed:First, SBK is emotionally not able to manage their emotions, but capable of fostering social relationships with both. Spiritually, SBK has not been able to practice well, but was able to do good to both parents. Second, the role of teachers Counseling (BK) in fostering ESQ as: a communicator, facilitator, motivator and advisor. Third, the implementation of the BK inhibiting factors include: the student's family background differences, and differences in the characteristics of individual students. While supporting factors include: BK teacher morale in providing guidance and mentoring, and guardians Abstrak Latar belakang penelitian ini adalah kebutuhan Siswa Berkebutuhan Khusus (SBK) di SMP PGRI Kasihan akan penanganan ekstra dari guru Bimbingan Konseling (BK) dalam pengembangan Kecerdasan Emosional dan Spiritual (ESQ). Hasil penelitian menunjukkan: Pertama, SBK secara emosional belum mampu mengelola emosi, namun mampu membina hubungan sosial dengan baik. Secara spiritual, SBK belum mampu menjalankan ibadah dengan baik, namun mampu berbuat baik kepada kedua orang tua. Kedua, Peran guru Bimbingan Konseling (BK) dalam membina ESQ sebagai: komunikator, pendamping, motivator dan penasehat. Ketiga, faktor penghambat pelaksanaan BK meliputi: perbedaan latar belakang keluarga siswa, dan perbedaan karakteristik individu siswa. Sedangkan faktor pendukungnya meliputi: semangat kerja guru BK dalam memberikan bimbingan, dan pendampingan, dan wali murid.
Effect of Large Particles During Chemical Mechanical Polishing Based on Numerical Modeling of Abrasive Particle Trajectories and Material Removal Non-Uniformity

A numerical simulation that describes particle trajectories during chemical mechanical polishing by Zhao et al. was extended to account for the effects of larger particles in a slurry, particle location changes due to slurry dispensing and in-situ conditioning. Material removal rate (MRR) and within wafer non-uniformity were determined based on the calculated particle trajectory densities in the absence of chemical activity from the slurry and assuming that the pressure is uniform and constant. The effect of pad-wafer rotary dynamics and reciprocating motion of the wafer carrier on MRR uniformity were evaluated and typically edge-fast MRR profiles were obtained. It was also shown that in-situ conditioning improves the MRR uniformity of the polished wafers. Using the model, we also investigated the effect of particle size distribution and large particles (>200 nm in diameter) on wafer uniformity and scratch growth and compared with some of our wafer level defect data. It was shown that the presence of even 1 wt. % of larger particles can deteriorate the wafer uniformity.
Induced production of α-tocotrienol by co-suppression of tocopherol cyclase gene in vegetable crops.

This study involves the induced production of α-tocotrienol by the co-suppression of tocopherol cyclase gene. The Tocopherol/Tocotrienol Cyclase (TC) is a key enzyme involved in the biosynthesis of α-tocotrienol. The partial conserved cDNA of TC gene isolated from the oil palm (Elaeis guineensis) that shared greater than 75% sequence identity with TC sequences from other plant species was used to silence TC gene expression in Amaranthus sp. and Allium porrum leaves by co-suppression strategies. This was carried out using recombinant vector constructs designated as p4a11 and p4c9 containing TC driven by the maize ubiquitin promoter (Ubi1P) and the oil palm leaf-specific promoter (LHCB), respectively. In the Amaranthus sp. leaves infiltrated with p4a11, the α-tocopherol suppression was 85.0, 71.0 and 74.0% on day three, five and seven, respectively and complete suppression was observed in the leaves infiltrated with p4c9. Whereas, only 11.0, 7.0 and 29.0% suppression was detected in Allium porrum leaves infiltrated with p4a11 and 45.0, 4.0 and 57.0% of suppression was observed in Allium porrum infiltrated with p4c9 on day three, five and seven, respectively. Silencing of TC gene driven by LHCB (p4c9) causes the reduction of α-tocopherol production better than by Ubi1P (p4a11). The results have demonstrated that gene silencing through co-suppression is capable of producing α-tocotrienol. However, there is no correlation between the α-tocotrienol production and the α-tocopherol suppression. It has been suggested that the transgene mediated co-suppression mechanism had triggered the vitamin E biosynthesis metabolic pathway to shift towards producing α-tocotrienol.
The intervention effect of aspirin on a lipopolysaccharide-induced preeclampsia-like mouse model by inhibiting the nuclear factor-κB Pathway†

Abstract Preeclampsia is a severe pregnancy-related disorder, and patients usually present with high circulating inflammatory factor levels and excessive activation of the nuclear factor-κB (NF-κB) pathway. Administration of aspirin (ASP) is effective for preventing preeclampsia, and thus, we propose that ASP might affect placental function by regulating the NF-κB pathway. Systemic lipopolysaccharide (LPS) (20 µg/kg) was used to induce preeclampsia-like pregnant mouse model, and low-dose ASP (15.2mg/kg) was administrated. Here, we report significantly increased circulatory expression levels of the proinflammatory cytokines tumor necrosis factor-alpha, interleukin-6, and soluble Fms-related tyrosine kinase-1 in LPS-treated pregnant mice, accompanied by kidney and placental dysfunction. Low-dose ASP treatment significantly reversed the preeclampsia-like phenotype, lowering hypertension, decreasing proteinuria, and ameliorating fetal growth retardation. Moreover, the excessive activation of NF-κB signaling in mice placentae induced by LPS was significantly reduced by ASP. In JEG-3 cells, LPS activated the NF-κB signaling pathway by upregulating the expression of cyclooxygenase-2 (COX-2) and related inflammatory factors, whereas the invasion ability of JEG-3 cells was weakened. However, ASP administration impeded NF-κB signaling activation, downregulated COX-2 and inflammatory factor expression, and rescued trophoblast invasion. This study provides new evidence that low-dose ASP is beneficial for preeclampsia prevention by inhibiting NF-κB and its downstream signaling pathways in trophoblast cells. Summary Sentence Low-dose ASP is beneficial for preventing LPS-induced preeclampsia by inhibiting NF-κB and downstream signaling pathways in trophoblast cells.
Regional differences in cortical bone organization and microdamage prevalence in Rocky Mountain mule deer.

The limb bones of cursorial mammals may exhibit regional structural/material variations for local mechanical requirements. For example, it has been hypothesized that mineral content (%ash) and secondary osteon population density (OPD) progressively change from proximal (e.g., humerus) to distal (e.g., phalanx), in accordance with corresponding progressive changes in stress and mechanical/metabolic cost of functional use (both greatest in the distal limb). We tested this hypothesis in wild-shot Rocky Mountain mule deer by examining transverse segments from mid-diaphyses of medial proximal phalanges, principal metacarpals, radii, and humeri, as well as the lateral aspects of sixth ribs from each of 11 mature males. Quantified structural parameters included the section modulus (Z), polar moment of inertia (J), cortical area/total area ratio (CA/TA), bone girth, and cortical thickness. In addition, %ash and the prevalence of in vivo microcracks were measured in each bone. Thin sections from seven animals were further examined for OPD and population densities of new remodeling events (NREs). Results showed a significant progressive decrease in %ash from the humerus (75.4% +/- 0.9%) to the phalanx (69.4% +/- 1.1%) (P < 0.0001), with general proximal-to-distal increases in OPD and general decreases in J and Z. Thirteen microcracks were identified in the rib sections, and only two were observed in the limb bones. Although the ribs had considerably greater NREs, no significant differences in NREs were found between the limb bones, indicating that they had similar remodeling rates. Equivalent microcrack prevalence, but nonequivalent structural/material organization, suggests that there are regional adaptations that minimize microcrack production in locations with differences in loading conditions. The progressive proximal-to-distal decrease in %ash (up to 6%); moderate-to-high correlations between OPD, %ash, J, and CA/TA; and additional moderate-to-high correlations of these parameters with each bone's radius of gyration support the possibility that these variations are adaptations for regional loading conditions.
Sex-limited expression of ornamental feathers in birds

Extravagant secondary sexual characters show sexual size dimorphism in some species but are completely sex limited in others. Sexual ornamentation has been hypothesized to benefit mainly males through sexual selection, but the costs of secondary sexual characters initially would be experienced by both sexes. The evolution of sexual size dimorphism of ornaments and, eventually, the complete sex-limited expression of these characters, will depend on the effects of sexual and natural selection on the two sexes. A phylogenetic analysis controlling for similarities due to common ancestry of 60 independent evolutionary origins of feather ornamentation in birds was used to investigate ecological factors correlated with sexual size dimorphism and sex-limited expression of secondary sexual characters. When the size of an ornament is large relative to body size, the trait will be particularly costly for females, resulting in selection for increased sexual size dimorphism of the ornament. Indeed, sexual size dimorphism of ornaments was positively related to the relative size of male ornaments but was unrelated to relative size of female ornaments. Species with polygynous and lekking mating systems with little or no male parental care (in particular nest building and incubation) demonstrated sex-limited expression of ornaments as compared to monogamous species. Species with no food provisioning of offspring by the male showed a trend for increased sexual size dimorphism of ornaments. Therefore, large natural selection costs during reproduction imposed by the expression of secondary sexual characters are related to the evolution of sexual size dimorphism of ornaments and eventually their complete loss from females.
Portal vein thrombosis in cirrhosis: diagnosis, natural history, and therapeutic challenges

Portal vein thrombosis (PVT) is a frequent complication in cirrhosis and its prevalence increases with disease severity. Several factors are involved in the development and progression of PVT. The challenge for the management of PVT is the precise evaluation of the bleeding risk as opposed to life-threatening extension of thrombosis. Nevertheless, the impact on the progression and outcome of liver disease is unclear. A critical evaluation of the available data discloses that treating PVT in cirrhotics is safe and effective. However, there are open issues, such as which anticoagulant could represent a safer therapeutic option, and when and for how long this treatment should be administered to cirrhotic patients with PVT.
Comparative genomics of the nonlegume Parasponia reveals insights into evolution of nitrogen-fixing rhizobium symbioses

Significance Fixed nitrogen is essential for plant growth. Some plants, such as legumes, can host nitrogen-fixing bacteria within cells in root organs called nodules. Nodules are considered to have evolved in parallel in different lineages, but the genetic changes underlying this evolution remain unknown. Based on gene expression in the nitrogen-fixing nonlegume Parasponia andersonii and the legume Medicago truncatula, we find that nodules in these different lineages may share a single origin. Comparison of the genomes of Parasponia with those of related nonnodulating plants reveals evidence of parallel loss of genes that, in legumes, are essential for nodulation. Taken together, this raises the possibility that nodulation originated only once and was subsequently lost in many descendant lineages. Nodules harboring nitrogen-fixing rhizobia are a well-known trait of legumes, but nodules also occur in other plant lineages, with rhizobia or the actinomycete Frankia as microsymbiont. It is generally assumed that nodulation evolved independently multiple times. However, molecular-genetic support for this hypothesis is lacking, as the genetic changes underlying nodule evolution remain elusive. We conducted genetic and comparative genomics studies by using Parasponia species (Cannabaceae), the only nonlegumes that can establish nitrogen-fixing nodules with rhizobium. Intergeneric crosses between Parasponia andersonii and its nonnodulating relative Trema tomentosa demonstrated that nodule organogenesis, but not intracellular infection, is a dominant genetic trait. Comparative transcriptomics of P. andersonii and the legume Medicago truncatula revealed utilization of at least 290 orthologous symbiosis genes in nodules. Among these are key genes that, in legumes, are essential for nodulation, including NODULE INCEPTION (NIN) and RHIZOBIUM-DIRECTED POLAR GROWTH (RPG). Comparative analysis of genomes from three Parasponia species and related nonnodulating plant species show evidence of parallel loss in nonnodulating species of putative orthologs of NIN, RPG, and NOD FACTOR PERCEPTION. Parallel loss of these symbiosis genes indicates that these nonnodulating lineages lost the potential to nodulate. Taken together, our results challenge the view that nodulation evolved in parallel and raises the possibility that nodulation originated ∼100 Mya in a common ancestor of all nodulating plant species, but was subsequently lost in many descendant lineages. This will have profound implications for translational approaches aimed at engineering nitrogen-fixing nodules in crop plants.