Miracle-dz/UniFAR-FTUs huggingface dataset:
Dynamic Free-Form Deformations for Animation Synthesis

Free form deformations (FFDs) are a popular tool for modeling and keyframe animation. The paper extends the use of FFDs to a dynamic setting. Our goal is to enable normally inanimate graphics objects, such as teapots and tables, to become animated, and learn to move about in a charming, cartoon like manner. To achieve this goal, we implement a system that can transform a wide class of objects into dynamic characters. Our formulation is based on parameterized hierarchical FFDs augmented with Lagrangian dynamics, and provides an efficient way to animate and control the simulated characters. Objects are assigned mass distributions and elastic deformation properties, which allow them to translate, rotate, and deform according to internal and external forces. In addition, we implement an automated optimization process that searches for suitable control strategies. The primary contributions of the work are threefold. First, we formulate a dynamic generalization of conventional, geometric FFDs. The formulation employs deformation modes which are tailored by the user and are expressed in terms of FFDs. Second, the formulation accommodates a hierarchy of dynamic FFDs that can be used to model local as well as global deformations. Third, the deformation modes can be active, thereby producing locomotion.
Comparison of right ventricular longitudinal strain imaging, tricuspid annular plane systolic excursion, and cardiac biomarkers for early diagnosis of cardiac involvement and risk stratification in primary systematic (AL) amyloidosis: a 5-year cohort study.

AIMS To determine the role of assessing right ventricular (RV) function, using standard echocardiography and Doppler myocardial imaging (DMI), in the early diagnosis of cardiac amyloidosis and in the prediction of mortality. METHODS AND RESULTS Patients with primary systemic (AL) amyloidosis seen at our institution from 1 February 2004 through 31 October 2005 (N=249) were categorized by left ventricular thickness and E' velocity and compared with 38 age- and sex-matched controls. Standard echocardiographic and DMI examination were used to measure echocardiographic parameters of RV function: systolic tissue velocity, strain rate, and strain were determined for basal and middle RV free wall segments. Patients were followed up for the endpoint of mortality. RV tricuspid annular plane systolic excursion (TAPSE) and all DMI measurements were lower in patients with AL amyloidosis and normal echocardiography results (AL-normal-echo group) than controls. A bivariate model including strain of the basal segment of the RV free wall and TAPSE was the best for distinguishing AL-normal-echo patients from controls. Male sex [hazard ratio (HR), 2.2; P=0.005], brain natriuretic peptide levels (HR 1.4; P=0.003), troponin T levels (HR 1.6; P=0.01), pleural effusion (HR 3.6; P<0.001), E/A ratio (HR 1.3; P=0.006), RV systolic pressure (HR 1.02; P=0.01), and RV strain rate of the middle segment (HR 1.3; P=0.02) were independent predictors of death. CONCLUSION DMI measures of the RV can identify early impairment of cardiac function or stratify risk of death in patients with AL amyloidosis. Further studies with longer follow-up are warranted to confirm these results.
User Interaction with Scatterplots on Small Screens - A Comparative Evaluation of Geometric-Semantic Zoom and Fisheye Distortion

Existing information-visualization techniques that target small screens are usually limited to exploring a few hundred items. In this article we present a scatterplot tool for Personal Digital Assistants that allows the handling of many thousands of items. The application's scalability is achieved by incorporating two alternative interaction techniques: a geometric-semantic zoom that provides smooth transition between overview and detail, and a fisheye distortion that displays the focus and context regions of the scatterplot in a single view. A user study with 24 participants was conducted to compare the usability and efficiency of both techniques when searching a book database containing 7500 items. The study was run on a pen-driven Wacom board simulating a PDA interface. While the results showed no significant difference in task-completion times, a clear majority of 20 users preferred the fisheye view over the zoom interaction. In addition, other dependent variables such as user satisfaction and subjective rating of orientation and navigation support revealed a preference for the fisheye distortion. These findings partly contradict related research and indicate that, when using a small screen, users place higher value on the ability to preserve navigational context than they do on the ease of use of a simplistic, metaphor-based interaction style.
Reference Evapotranspiration Variation Analysis and Its Approaches Evaluation of 13 Empirical Models in Sub-Humid and Humid Regions: A Case Study of the Huai River Basin, Eastern China

Accurate and reliable estimations of reference evapotranspiration (ET0) are imperative in irrigation scheduling and water resource planning. This study aims to analyze the spatiotemporal trends of the monthly ET0 calculated by the Penman–Monteith FAO-56 (PMF-56) model in the Huai River Basin (HRB), eastern China. However, the use of the PMF-56 model is limited by the insufficiency of climatic input parameters in various sites, and the alternative is to employ simple empirical models. In this study, the performances of 13 empirical models were evaluated against the PMF-56 model by using three common statistical approaches: relative root-mean-square error (RRMSE), mean absolute error (MAE), and the Nash–Sutcliffe coefficient (NS). Additionally, a linear regression model was adopted to calibrate and validate the performances of the empirical models during the 1961–2000 and 2001–2014 time periods, respectively. The results showed that the ETPMF increased initially and then decreased on a monthly timescale. On a daily timescale, the Valiantzas3 (VA3) was the best alternative model for estimating the ET0, while the Penman (PEN), WMO, Trabert (TRA), and Jensen-Haise (JH) models showed poor results with large errors. Before calibration, the determination coefficients of the temperature-based, radiation-based, and combined models showed the opposite changing trends compared to the mass transfer-based models. After calibration, the performance of each empirical model in each month improved greatly except for the PEN model. If the comprehensive climatic datasets were available, the VA3 would be the recommended model because it had a simple computation procedure and was also very well correlated linearly to the PMF-56 model. Given the data availability, the temperature-based, radiation-based, Valiantzas1 (VA1) and Valiantzas2 (VA2) models were recommended during April–October in the HRB and other similar regions, and also, the mass transfer-based models were applicable in other months.
Sclerostin influences body composition by regulating catabolic and anabolic metabolism in adipocytes

Significance Sclerostin exerts profound control over skeletal metabolism by regulating the osteoanabolic Wnt/β-catenin signaling pathway. In this study, we demonstrate that in addition to a dramatic increase in bone mass, Sost−/− mice as well as those treated with a sclerostin-neutralizing antibody exhibit a reduction in white adipose tissue mass and are protected from high fat diet feeding. This effect is associated with an increase in fatty acid oxidation and reduced de novo fatty acid synthesis in adipocytes due to increased Wnt/β-catenin signaling. Sclerostin has traditionally been thought of as a local inhibitor of bone acquisition that antagonizes the profound osteoanabolic capacity of activated Wnt/β-catenin signaling, but serum sclerostin levels in humans exhibit a correlation with impairments in several metabolic parameters. These data, together with the increased production of sclerostin in mouse models of type 2 diabetes, suggest an endocrine function. To determine whether sclerostin contributes to the coordination of whole-body metabolism, we examined body composition, glucose homeostasis, and fatty acid metabolism in Sost−/− mice as well as mice that overproduce sclerostin as a result of adeno-associated virus expression from the liver. Here, we show that in addition to dramatic increases in bone volume, Sost−/− mice exhibit a reduction in adipose tissue accumulation in association with increased insulin sensitivity. Sclerostin overproduction results in the opposite metabolic phenotype due to adipocyte hypertrophy. Additionally, Sost−/− mice and those administered a sclerostin-neutralizing antibody are resistant to obesogenic diet-induced disturbances in metabolism. This effect appears to be the result of sclerostin’s effects on Wnt signaling and metabolism in white adipose tissue. Since adipocytes do not produce sclerostin, these findings suggest an unexplored endocrine function for sclerostin that facilitates communication between the skeleton and adipose tissue.
The divergence between acceptability of municipal services and urbanization in developing countries: insights from Accra and Sekondi-Takoradi, Ghana

Abstract In most developing countries, the provision of municipal services and infrastructure invariably fails to match the pace and demands of urbanization. The outcome is often increased informality due to improper planning, official bureaucratic barriers and perhaps insufficient and shrinking public resources, which then makes leveraging private capital for public service provision imperative. Drawing on in-depth qualitative fieldwork in two Ghanaian cities, this paper aims to extend literature on the divergence between service provision and urbanization in developing countries. More specifically, it attempts to qualify recent macro-level data indicating that access to water, sanitation and electricity services in Accra and Sekondi-Takoradi is improving substantively. Contrary to dominant policy narratives circulating in Ghana, we illustrate how the acceptability of key municipal services within urban settings is often inadequate, and how acceptability is tied to spatial and temporal factors. We then identify and examine the reasons underpinning these variations. Through exploring residents’ perceptions of key services, and examining critically the possibility and feasibility of meeting urban service needs through leveraging private resources, this paper contributes to broader academic debates over urban service provision, while also feeding into contemporary policy discussions concerning how to achieve several of the Sustainable Development Goals by 2030.
A Phase II Randomized Clinical Trial of a Nutritional Formulation for Cognition and Mood in Alzheimer's Disease.

BACKGROUND Increasing evidence points toward the efficacy of nutritional modifications in delaying cognitive decline and mood/behavioral difficulties in Alzheimer's disease (AD). Nutritional supplementation with individual agents has shown varied results suggesting the need for combinatorial intervention. OBJECTIVE We set out to determine whether nutritional intervention could positively impact cognitive performance and behavioral difficulties for individuals diagnosed with AD. METHODS A double-blind, multi-site, phase II study (ClinicalTrials.gov NCT01320527; Alzheimer's Association Trialmatch) was conducted in which 106 individuals with AD were randomized to a nutraceutical formulation (NF; folate, alpha-tocopherol, B12, S-adenosyl methioinine, N-acetyl cysteine, acetyl-L-carnitine) or placebo for 3 or 6 months, followed by an open-label extension where participants received NF for 6 additional months. RESULTS The NF cohort improved versus the placebo cohort within 3 months (Clox-1 p = 0.0083, 95%CI [0.4481, 2.9343]; Dementia Rating Scale p = 0.0266, 95%CI [0.1722, 2.7171]). Caregivers reported non-significant improvements in Neuropsychiatric Inventory. Both cohorts improved or maintained baseline performance during open-label extensions. Activities of Daily Living did not change for either cohort. CONCLUSIONS These findings extend phase I studies where NF maintained or improved cognitive performance and mood/behavior.
Health Economic Analysis of the Swedish Neonatal Metabolic Screening Programme

A benefit-cost analysis was carried out to optimize the routines for neonatal metabolic screening. The basis of the study was provided by results of the Swedish neonatal screening programme from 1965 to 1979. During this period over one million infants were screened by the Guthrie test for phenylketonuria and galactosaemia, and for limited periods also for tyrosinaemia, homocystinuria and histidinaemia. The benefit-cost ratio was calculated for combinations of different screening tests, recall routines, and varying degrees of coverage. The largest benefit-cost ratio was obtained with combined screening for phenylketonuria and galactosaemia, using a borderline blood phenylalanine level of 0.50 mmol/L in the Guthrie test for phenylketonuria. However, the inaccuracy of this test necessitated the use of a lower blood phenylalanine level of 0.25 mmol/L and the acceptance of a lower benefit-cost ratio. An increase in the present 98% coverage of newborns by the screening programme was found to be an effective means of improving the benefit-cost ratio in the present programme.
Mathematical modelling of the electric sense of fish: the role of multi-frequency measurements and movement

Understanding active electrolocation in weakly electric fish remains a challenging issue. In this article we propose a mathematical formulation of this problem, in terms of partial differential equations. This allows us to detail two algorithms: one for localizing a target using the multi-frequency aspect of the signal, and another one for identifying the shape of this target. Shape recognition is designed in a machine learning point of view, and takes advantage of both the multi-frequency setup and the movement of the fish around its prey. Numerical simulations are shown for the computation of the electric field emitted and sensed by the fish; they are then used as an input for the two algorithms.
Sensitivity, specificity, and predictive values of the Limulus lysate assay for detection of exclusion of gonococcal cervicitis

The Limulus amoebocyte lysate (LAL) assay was evaluated for its ability to detect or exclude gonococcal cervicitis in two groups of women. The first (positive) group consisted of 100 untreated women who were referred to the venereal disease clinic with culture-proven gonococcal cervicitis. The second (negative) group consisted of 50 normal volunteers who were evaluated on two separate occasions. In the first group, Gram stains and repeat cervical cultures were 53 and 93% sensitive, respectively. In the second group, Gram stains and cultures were negative. For the LAL assay, ectocervical mucus was removed with a sponge, and a depyrogenated cotton-tipped swab was then used to collect endocervical specimens. The swab was placed in 1 ml of diluent (1:1 dilution), and serial twofold dilutions were made and tested for endotoxin by the LAL assay. Incubation was carried out at 37 degrees C for 30 min; positive or negative results were indicated by gelation or lack of gelation, respectively. At a dilution of 1:256, sensitivity and specificity of the LAL assay were 57 and 99%, respectively. The positive predictive values ranged from 36.5 to 97.4% for theoretical prevalence rates of 1 to 40%. At a dilution of 1:8, the sensitivity and specificity were 100 and 78%, respectively. At this dilution, the negative predictive value was 100% regardless of the prevalence rate. Thus, these preliminary results show that at the higher dilution, the LAL assay was comparable to Gram stain in diagnostic accuracy of gonococcal cervicitis, and if used as a screening test at the lower dilution, a negative LAL assay would exclude women without gonococcal cervicitis.
Active Neutral-Point-Clamped Multilevel Converters

This paper proposes a multilevel power conversion concept based on the combination of neutral-point-clamped (NPC) and floating capacitor converters. In the proposed scheme, the voltage balancing across the floating capacitors is achieved by using a proper selection of redundant switching states, and the neutral-point voltage is controlled by the classical dc offset injection. Experimental results are illustrated in the paper to demonstrate the system operation
Job-related “high mobility” in times of economic crisis: Analysis from four European countries

ABSTRACT Social and spatial mobility is a core value of late modern societies. Increasing numbers of people are practicing work-related high mobility, such as daily or weekly long-distance commuting and frequent work-related travel. In this article we propose to explore the impact of the economic crisis on job-related high mobility. The data used come from a European longitudinal quantitative survey (in Germany, Spain, France, and Switzerland) of work-related mobile individuals. Several dimensions are considered, including mobility practices and perceptions thereof and individuals’ abilities and willingness to move. Faced with an economic crisis, working people are turning to these forms of intensive work-related high mobility. Unemployment, or the risk of it, encourages people to plan high mobility for the future because it proves to be an important resource for access to jobs/employment. However, those affected are often poorly served by transport infrastructure and have weak mobility skills.
New Highly Divergent rRNA Sequence among Biodiverse Genotypes of Enterocytozoon bieneusi Strains Isolated from Humans in Gabon and Cameroon

ABSTRACT Intestinal microsporidiosis due to Enterocytozoon bieneusi is a leading cause of chronic diarrhea in severely immunocompromised human immunodeficiency virus (HIV)-positive patients. It may be a public health problem in Africa due to the magnitude of the HIV pandemic and to poor sanitary conditions. We designed two prevalence studies of E. bieneusi in Central Africa, the first with HIV-positive patients from an urban setting in Gabon and the second with a nonselected rural population in Cameroon. Stool samples were analyzed by an immunofluorescence antibody test and PCR. Twenty-five out of 822 HIV-positive patients from Gabon and 22 out of 758 villagers from Cameroon were found to be positive for E. bieneusi. The prevalence rates of the two studies were surprisingly similar (3.0% and 2.9%). Genotypic analysis of the internal transcribed spacer region of the rRNA gene showed a high degree of diversity in samples from both countries. In Gabon, 15 isolates showed seven different genotypes: the previously reported genotypes A, D, and K along with four new genotypes, referred to as CAF1, CAF2, CAF3, and CAF4. In Cameroon, five genotypes were found in 20 isolates: the known genotypes A, B, D, and K and the new genotype CAF4. Genotypes A and CAF4 predominated in Cameroon, whereas K, CAF4, and CAF1 were more frequent in Gabon, suggesting that different genotypes present differing risks of infection associated with immune status and living conditions. Phylogenetic analysis of the new genotype CAF4, identified in both HIV-negative and HIV-positive subjects, indicates that it represents a highly divergent strain.
Sox18 Genetically Interacts With VegfC to Regulate Lymphangiogenesis in Zebrafish

Objective—Lymphangiogenesis is regulated by transcription factors and by growth factor pathways, but their interplay has not been extensively studied so far. We addressed this issue in zebrafish. Approach and Results—Mutations in the transcription factor–coding gene SOX18 and in VEGFR3 cause lymphedema, and the VEGFR3/Flt4 ligand VEGFC plays an evolutionarily conserved role in lymphangiogenesis. Here, we report a strong genetic interaction between Sox18 and VegfC in the early phases of lymphatic development in zebrafish. Knockdown of sox18 selectively impaired lymphatic sprouting from the cardinal vein and resulted in defective lymphatic thoracic duct formation. Sox18 and the related protein Sox7 play redundant roles in arteriovenous differentiation. We used a novel transgenic line that enables inducible expression of a dominant-negative mutant form of mouse Sox18 protein. Our data led us to conclude that Sox18 is crucially involved in lymphangiogenesis after arteriovenous differentiation. Combined partial knockdown of sox18 and vegfc, using subcritical doses of specific morpholinos, revealed a synergistic interaction in both venous and lymphatic sprouting from the cardinal vein and greatly impaired thoracic duct formation. Conclusions—This interaction suggests a previously unappreciated crosstalk between the growth factor and transcription factor pathways that regulate lymphangiogenesis in development and disease.
The effects of a secondary task on forward and backward walking in Parkinson's disease.

BACKGROUND People with Parkinson's disease (PD) often fall while multitasking or walking backward, unavoidable activities in daily living. Dual tasks involving cognitive demand during gait and unfamiliar motor skills, such as backward walking, could identify those with fall risk, but dual tasking while walking backward has not been examined in those with PD, those who experience freezing of gait (FOG), or healthy older controls. METHODS A total of 78 people with PD (mean age = 65.1 +/-9.5 years; female, 28%) and 74 age-matched and sex-matched controls (mean age = 65.0 +/-10.0 years; female, 23%) participated. A computerized walkway measured gait velocity, stride length, swing percent, stance percent, cadence, heel to heel base of support, functional ambulation profile, and gait asymmetry during forward and backward walking with and without a secondary cognitive task. RESULTS Direction and task effects on walking performance were similar between healthy controls and those with PD. However, those with PD were more affected than controls, and freezers were more affected than nonfreezers, by backward walking and dual tasking. Walking backward seemed to affect gait more than dual tasking in those with PD,although the subset of freezers appeared particularly affected by both challenges. CONCLUSION People with PD are impaired while performing complex motor and mental tasks simultaneously,which may put them at risk for falling. Those with FOG are more adversely affected by both motor and mental challenges than those without. Evaluation of backward walking while performing a secondary task might be an effective clinical tool to identify locomotor difficulties.
Typicality Effects and the Logic of Reciprocity

The variability in the interpretation of reciprocal expressions has been extensively addressed in the literature and received detailed semantic accounts. After pointing out a central empirical limitation of previous logical accounts of reciprocity, we argue that these approaches suffer from inadequacies due to ignoring typicality preferences with binary predicate concepts. We claim that typicality preferences are crucial for interpreting reciprocals and introduce a new principle, the Maximal Typicality Hypothesis (MTH), which analyzes reciprocals using an extension of the Strongest Meaning Hypothesis (SMH) proposed in Dalrymple et al. (1998) Unlike the SMH, which is a principle that implicitly presupposes a classical two-valued (“definitional”) treatment of predicate concepts, the MTH respects the fuzziness of such concepts as manifested by their typicality preferences, and expects strong correlations between these preferences and the range of logical interpretations available for reciprocal expressions. The expected correlations are supported by new empirical results elicited in a series of experiments with speakers of Hebrew. Section 2 discusses the SMH and a major challenge for it. Section 3 briefly reviews previous work on typicality in the theory of concepts. Section 4 introduces the MTH and its formalization. Section 5 discusses the empirical settings we used for testing the MTH and introduces our experimental results and their analysis. Section 6 analyzes these results and their implication for the MTH.