Miracle-dz/UniFAR-FTUs huggingface dataset:
Dissociation, Paranormal Belief, and Quality of Life in Older People

The measurement of religiosity in current health-related literature is mostly based on the traditional Christian belief system. It has been argued that such a measurement approach may misrepresent the true degree of religiosity in Taiwanese people. In this study, religiosity was measured in two ways: self-reported religion type and a qualitatively derived index of religious piety based on principles as suggested by Gries, Su, and Schak to be used in the Taiwanese context. Their effects on dissociation, paranormal belief, and quality of life were juxtaposed for comparison. In addition, the beneficial effect of religious piety was examined in the framework of McClenon’s ritual healing theory. A total of 266 healthy older adults across Taiwan were interviewed by four trained assistants over a 4-month period. Factor scores were used to represent the dissociative tendencies (depersonalization/derealization, forgetfulness, amnesia, and psychological absorption) and paranormal belief facets (precognition, psi power, other forms of life, traditional religious belief, superstition, and telepathy). The results showed that older people of high religious piety display better quality of life profiles than their counterparts in the low religious piety group. The effects of self-reported religion type were mainly seen with paranormal beliefs compatible with their religious beliefs, whereas the effects of religious piety were more pronounced in relation to quality of life than dissociation and paranormal belief. The beneficial advantage of dissociation hypothesized by ritual healing theory did not receive empirical support in the nonclinical sample of this study.
Cyclosporin A metabolism in human liver, kidney, and intestine slices. Comparison to rat and dog slices and human cell lines.

This study assesses the contribution of cyclosporin A (CsA) metabolism at sites of CsA-induced toxicity: kidney and liver, and a site of absorption, the intestine. With organ slice cultures (8 mm phi), it has been possible to demonstrate that the extrahepatic metabolism of CsA is significant. Both human kidney and colonic mucosal tissue metabolize CsA (1 microM, 24 hr) as analyzed by HPLC. The major metabolite M17 was formed in the kidney at an initial rate of 3 pmol/hr/mg slice protein, which was comparable to M17 formation in the liver slices (5 pmol/hr/mg slice protein). The rate of total CsA metabolism by human kidney slices represents about 42% the rate in liver slices. The metabolism of CsA to M17 was the same in the human kidney cell line 293; however, CsA metabolism was not detectable using human kidney microsomes, nor was metabolism clearly evident in either rat or dog kidney slice cultures. The metabolism of CsA by human colonic mucosal slices to at least three metabolites and the metabolism of CsA by the human intestinal cell line FHs74 Int indicates that the intestinal metabolism of CsA contributes to the first-pass effect of the drug. The liver proved to be the major site of CsA biotransformation in terms of the complexity of metabolites produced, whereas the human liver HepG2 cell line proved not to be a suitable model for CsA metabolism. A time course revealed that the first metabolites formed in the liver slice cultures were the monohydroxylated, M1 and M17, and N-demethylated, M21, followed by the secondary metabolites (including M8, M13, and M18). (ABSTRACT TRUNCATED AT 250 WORDS)
Do statins interfere with lifestyle intervention in the prevention of diabetes in primary healthcare? One-year follow-up of the FIN-D2D project

Objectives To examine whether the use of statins is associated with the incidence of type 2 diabetes (T2D) and changes in glucose metabolism among individuals at high risk for T2D participating in 1-year lifestyle intervention in primary healthcare setting. Design Prospective follow-up study. Setting In all, 400 primary healthcare centres and occupational healthcare clinics in Finland. Participants We screened altogether 10 149 individuals at increased risk for T2D; of these, 2798 non-diabetic individuals verified by a 2 h glucose tolerance test participated in the 1-year follow-up. Interventions Lifestyle intervention (individual and/or group-based counselling). Primary outcome measures Incidence of T2D and fasting and 2 h glucose measured at baseline and follow-up. Results A total of 484 individuals (17.3%) used statins at the baseline. Of them 31 (7.5%) developed T2D during the follow-up, compared to 126 (6.5%) of statin non-users (OR 1.17, 95% CI 0.78 to 1.76, p=0.442). Interestingly, fasting glucose increased by 0.08 mmol/l in statin users, but remained unchanged in non-users, the difference being 0.074 mmol/l (95% CI 0.014 to 0.134) and remained significant even after adjustment for age, sex, baseline fasting glucose, the presence of cardiovascular disease (CVD), use of antihypertensive and/or coronary artery disease medication, weight and 1-year weight change (adjusted p=0.042). Conclusions The incidence of T2D did not differ between the statin users and non-users. The finding that fasting glucose slightly increased in statin users in spite of lifestyle interventions suggests the view that the use of statins might have unfavourable effects on glucose metabolism and that statins might hamper beneficial effects of lifestyle intervention in people at high risk of T2D.
A role for vitamin A in the formation of ocular lipofuscin

BACKGROUND Lipofuscin granules in the retinal pigment epithelium are lipid protein aggregates which are thought to represent the lifelong accumulation of the non-degradable end products from the phagocytosis of photoreceptor outer segments. Given the increasing evidence for a key role for vitamin A in the formation of ocular lipofuscin, the fluorophores generated by reacting vitamin A with lipid were assessed. METHODS Reaction mixtures consisting of vitamin A (retinol) or its aldehyde (retinal) and (a) isolated rod outer segments, (b) the lipid extract of rod outer segments, (c) protein, or (d) liposomes were incubated at either pH 4.5 or 7.0 for up to 42 days. The fluorescence characteristics and mobility of the chloroform soluble fluorophores generated were compared with those extracted from purified human lipofuscin. Finally, the effect of lysosomal degradation on fluorophores generated in the above mixtures was assessed. RESULTS Major spectral changes were observed when ROS or liposomes were incubated with retinal. These changes were pH dependent and did not occur if retinal was replaced with retinol. A number of the fluorophores generated exhibited similar fluorescence characteristics and chromatographic mobility to those of lipofuscin. Neither the presence of protein nor exposure to lysosomal enzymes had any effect on the spectral profile or fluorophore mobility of the fluorophores generated. CONCLUSIONS These results suggest that some of the chloroform soluble fluorophores of lipofuscin are formed as a direct reaction product of retinal and lipid.
Determinants of approval of the work of truth commissions in the southern cone: a comparative study / Determinantes de la aprobación del trabajo realizado por las Comisiones de Verdad y Reconciliación en el cono sur: un estudio comparativo

Abstract The socio-demographic and psychosocial approval determinants of the work conducted by the truth and reconciliation commissions (TRC) are analysed based on original survey data from Chilean, Argentinian and Peruvian samples (N = 2,947). A linear multiple regression analysis was carried out (R2 between .28 and .44; f2 between .45 and .78) which reveals the positive effect of commission functions perceived achievement, mainly the knowledge of truth (β = .28), justice (β = .15) and the contribution in creating a common history (β = .15). An analysis by country reveals in Chile salient variables such as institutional trust, political ideas, institutional apologies and hope and sadness emotions. In Argentina, together with TRC functions, the degree of information about the work of the commission and the perception of a negative social climate appear as relevant predictors. As regards Peru, the degree of exposure to violence appears as a good predictor of TRC’s work support. The results show the relevance of TRC functions’ fulfillment, as well as the role of institutional variables in the approval of the work they have done.
The Hemolymph Proteome of Fed and Starved Drosophila Larvae

The co-operation of specialized organ systems in complex multicellular organisms depends on effective chemical communication. Thus, body fluids (like blood, lymph or intraspinal fluid) contain myriads of signaling mediators apart from metabolites. Moreover, these fluids are also of crucial importance for immune and wound responses. Compositional analyses of human body fluids are therefore of paramount diagnostic importance. Further improving their comprehensiveness should increase our understanding of inter-organ communication. In arthropods, which have trachea for gas exchange and an open circulatory system, the single dominating interstitial fluid is the hemolymph. Accordingly, a detailed analysis of hemolymph composition should provide an especially comprehensive picture of chemical communication and defense in animals. Therefore we used an extensive protein fractionation workflow in combination with a discovery-driven proteomic approach to map out the detectable protein composition of hemolymph isolated from Drosophila larvae. Combined mass spectrometric analysis revealed more than 700 proteins extending far beyond the previously known Drosophila hemolymph proteome. Moreover, by comparing hemolymph isolated from either fed or starved larvae, we provide initial provisional insights concerning compositional changes in response to nutritional state. Storage proteins in particular were observed to be strongly reduced by starvation. Our hemolymph proteome catalog provides a rich basis for data mining, as exemplified by our identification of potential novel cytokines, as well as for future quantitative analyses by targeted proteomics.
Polymerase chain reaction-amplified nonradioactive probes for identification of Fusobacterium nucleatum

A polymerase chain reaction probe with 100% sequence identity to 120 deoxyribonucleotides of Fusobacterium nucleatum Fev1, coding for a part of the 40-kDa major outer membrane protein, was labeled with the steroid hapten digoxigenin. The probe was compared with various degenerate oligonucleotide probes and found to tolerate much more stringent washing conditions. It was therefore superior in distinguishing, by means of Southern blots and slot blots, F. nucleatum from other oral gram-negative bacteria in the periodontal pocket and from other fusobacterial species and in distinguishing among different strains of F. nucleatum. F. periodonticum was found to be more similar to F. nucleatum than the other fusobacterial species tested.
Action planning fosters adoption of regular physical activity behavior among low-control individuals with high intention

This study aims to document how action planning (AcP) and coping planning (CP) (Gollwitzer, 1999) combines with the intention and perceived behavioral control (PBC) variables (Ajzen, 1991) to predict physical activity (PA) behavior. It was hypothesized that: 1) intention and the use of planning would each have a main effect on PA behavior, 2) AcP, with or without CP, would be useful to individuals with low PBC if their intention was high. In a quasi-experimental prospective design, 122 individuals were asked to engage regularly in PA for the 5 following weeks with the help of AcP alone, AcP and CP, or no planning at all. TPB variables and past month PA behavior were measured at T1 and frequency of PA was measured at T2. Results of an ANCOVA 2 (low vs high intention) X 3 (no planning, AcP, AcP + CP) X 3 (low, average or high PBC), which controlled for the infl uence of past behavior, revealed a main effect of intention and a signifi cant interaction between intention, planning and PBC. Simple effects analysis demonstrated that AcP alone improved PA frequency among low PBC individuals with high intention. Limits of the design as well as conceptual implications are discussed.
Identity, grief and self-awareness after traumatic brain injury

The objective of this study was to investigate perceived identity change in adults with traumatic brain injury (TBI) and explore associations between identity change, grief, depression, self-esteem and self-awareness. The participants were 29 adults with TBI who were being followed up by a community brain injury rehabilitation service. Participants were longer post-injury than those more commonly studied. Time since injury ranged from 2.25 to 40 years (mean = 11.17 years, SD = 11.4 years). Participants completed a battery of questionnaires. Significant others and clinicians completed a parallel version of one of these measures. Questionnaires included the Head Injury Semantic Differential Scale (HISDS-III), Brain Injury Grief Inventory (BIGI), Hospital Anxiety and Depression Scale – Depression, Rosenberg Self-Esteem Scale (RSES) and the Awareness Questionnaire (Self/Significant other/Clinician versions). The main findings were that participants reported significant changes in self-concept with current self being viewed negatively in comparison to pre-injury self. Perceived identity change was positively associated with depression and grief and negatively associated with self-esteem and awareness. Awareness was negatively associated with self-esteem and positively associated with depression. These findings were consistent with previous research, revealing changes in identity following TBI. Further research is needed to increase our understanding of the psychological factors involved in emotional adjustment after TBI and to inform brain injury rehabilitation interventions, including psychotherapy approaches.
School ties: Social capital and student performance in individual and group tasks

Purpose of the Study: This study seeks to understand the unique impact of social capital on student performance. We present hypotheses that link a student’s social capital to his/her performance on individual and group tasks. In both task settings, we posit that social capital has a curvilinear relationship (inverted U-shape) with performance, such that students’ performance is enhanced as social capital increases, but may exhibit declines if students over-invest in the initiation and development of their relationships
A qualitative narrative policy framework? Examining the policy narratives of US campaign finance regulatory reform

In 2010, the narrative policy framework was introduced as a positivist, quantitative, and structuralist approach to the study of policy narratives. Deviating from this central tenet of the narrative policy framework, in this article we show that the framework is quite compatible with qualitative methods—and the various epistemologies associated with them. To demonstrate compatibility between qualitative methods and the Narrative Policy Framework, we apply classic qualitative criteria to an illustrative case examining policy narratives in US campaign finance reform. Drawing on elite interviews, we illuminate competing policy narratives rooted in distinct democratic values that exhibit variation in how victims and harm are defined, how blame is attributed to villains, what policy solutions are put forth, and policy narrative communication strategies. Our incorporation of qualitative methods within the narrative policy framework is critical for the framework's overall development as it provides opportunities for more detailed description, inductive forms of inquiry, and grounded theory development in policy areas where sample sizes, access, and salience may limit quantitative approaches.
Ladies First: Analyzing Gender Roles and Behaviors in Pinterest

Online social networks (OSNs) have become popular platforms for people to connect and interact with each other. Among those networks, Pinterest has recently become noteworthy for its growth and promotion of visual over textual content. The purpose of this study is to analyze this image-based network in a gender-sensitive fashion, in order to un- derstand (i) user motivation and usage pattern in the network, (ii) how communications and social interactions happen and (iii) how users describe themselves to others. This work is based on more than 220 million items generated by 683,273 users. We were able to find significant differences w.r. t. all mentioned aspects. We observed that, although the network does not encourage direct social communication, females make more use of lightweight interactions than males. Moreover, females invest more effort in reciprocating social links, are more active and generalist in content generation, and describe themselves using words of affection and positive emotions. Males, on the other hand, are more likely to be specialists and tend to describe themselves in an assertive way. We also observed that each gender has different interests in the network, females tend to make more use of the network's commercial capabilities, while males are more prone to the role of curators of items that reflect their personal taste. It is important to understand gender differences in online social networks, so one can design services and applications that leverage human social interactions and provide more targeted and relevant user experiences.
Pan-private algorithms via statistics on sketches

Consider fully dynamic data, where we track data as it gets inserted and deleted. There are well developed notions of private data analyses with dynamic data, for example, using differential privacy. We want to go beyond privacy, and consider privacy together with security, formulated recently as pan-privacy by Dwork et al. (ICS 2010). Informally, pan-privacy preserves differential privacy while computing desired statistics on the data, even if the internal memory of the algorithm is compromised (say, by a malicious break-in or insider curiosity or by fiat by the government or law). We study pan-private algorithms for basic analyses, like estimating distinct count, moments, and heavy hitter count, with fully dynamic data. We present the first known pan-private algorithms for these problems in the fully dynamic model. Our algorithms rely on sketching techniques popular in streaming: in some cases, we add suitable noise to a previously known sketch, using a novel approach of calibrating noise to the underlying problem structure and the projection matrix of the sketch; in other cases, we maintain certain statistics on sketches; in yet others, we define novel sketches. We also present the first known lower bounds explicitly for pan privacy, showing our results to be nearly optimal for these problems. Our lower bounds are stronger than those implied by differential privacy or dynamic data streaming alone and hold even if unbounded memory and/or unbounded processing time are allowed. The lower bounds use a noisy decoding argument and exploit a connection between pan-private algorithms and data sanitization.
Continuous Light Increment Perimetry Compared to full Threshold Strategy in Glaucoma

Purpose Continuous light increment perimetry (CLIP) is an improved testing strategy for automated static perimetry designed to save test time and enhance patient compliance. CLIP uses a modified ramp stimulus where stimulus intensity is continuously increased according to patient reaction time, starting from a subthreshold intensity until recognition. The test is constantly modified according to patient performance. As CLIP showed good results in normal subjects in previous studies, the authors now compared CLIP to the standard 4/2-full threshold (4/2) strategy in glaucoma patients. Methods Fifty-two patients with glaucomatous visual field defects (mean sensitivities 2.9 to 18.4 dB), all with perimetric experience, were tested with CLIP (three times) and 4/2 in a randomized fashion. Tests were performed at 55 test locations within the central 30° visual field (24-2 area) using the Twinfield perimeter. Results Average mean sensitivity was significantly higher for CLIP than for 4/2 (t test, p<0.0001). Absolute scotomas and extension of scotomas were comparable for both strategies, whereas CLIP found less deep relative scotomas in some cases. Mean test time was significantly shorter for CLIP (5.6 min) compared to 4/2 (8.9 min) (Wilcoxon signed rank test, p<0.0001). Patient acceptance was better for CLIP than for 4/2. Conclusions CLIP showed comparable results to 4/2 with excellent patient acceptance. Mean sensitivities are 1.8 dB higher than for 4/2; similar results were found previously in normal subjects. CLIP was able to save a mean 38% of test time compared to full threshold strategy with good reproducibility.
Correlation of Temperature and Toxicity in Murine Studies of Staphylococcal Enterotoxins and Toxic Shock Syndrome Toxin 1

ABSTRACT This study describes a quick (<12 h) assay for detecting temperature decreases in BALB/c and C57BL/6 mice injected intraperitoneally (i.p.) with staphylococcal enterotoxin A (SEA), SEB, or SEC3 or toxic shock syndrome toxin 1 and a potentiating dose of lipopolysaccharide (LPS). Toxin-specific antisera effectively neutralized the temperature fluctuations in this model. Orally administered SEA or SEB (50 μg/animal), with or without LPS, did not have an effect on temperature or lethality. Versus wild-type mice, transgenic knockout mice lacking the p55 receptor for tumor necrosis factor (TNF) or gamma interferon were protected against an i.p. challenge of SEA plus LPS. The p75 receptor for TNF and intercellular adhesion molecule 1 have a negligible role in this toxic shock model.
Cortical responses to speech and complex tonal stimuli in adults with normal hearing and sensorineural hearing loss

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FHOD1 regulates stress fiber organization by controlling the dynamics of transverse arcs and dorsal fibers

ABSTRACT The formin FHOD1 (formin homology 2 domain containing protein 1) can act as a capping and bundling protein in vitro. In cells, active FHOD1 stimulates the formation of ventral stress fibers. However, the cellular mechanisms by which this phenotype is produced and the physiological relevance of FHOD1 function are not currently understood. Here, we first show that FHOD1 controls the formation of two distinct stress fiber precursors differentially. On the one hand, it inhibits dorsal fiber growth, which requires the polymerization of parallel bundles of long actin filaments. On the other hand, it stimulates transverse arcs that are formed by the fusion of short antiparallel actin filaments. This combined action is crucial for the maturation of stress fibers and their spatio-temporal organization, and a lack of FHOD1 function perturbs dynamic cell behavior during cell migration. Furthermore, we show that the GTPase-binding and formin homology 3 domains (GBD and FH3) are responsible for stress fiber association and colocalization with myosin. Surprisingly, a version of FHOD1 that lacks these domains nevertheless retains its full capacity to stimulate arc and ventral stress fiber formation. Based on our findings, we propose a mechanism in which FHOD1 promotes the formation of short actin filaments and transiently associates with transverse arcs, thus providing tight temporal and spatial control of the formation and turnover of transverse arcs into mature ventral stress fibers during dynamic cell behavior.