Miracle-dz/UniFAR-FTUs huggingface dataset:
Monitoring Weld Pool Surface and Penetration Using Reversed Electrode Images

The three­dimensional weld pool top surface shape provides important informa­ tion about the state of weld penetration during welding. In this study, a method was developed to quantitatively relate weld pool surface height to the reversed electrode image (REI) on the weld pool surface. This new feature was extracted from the weld pool image using a passive vision­based monitoring system during gas tungsten arc welding (GTAW). Due to the specular reflection of the weld pool top surface, the REI is visible on the weld pool surface during GTAW. The position of the REI was determined with a robust image processing algorithm. Based on the principle of light reflection, the distance between the electrode tip and the REI (DERI) was related to the weld pool surface height. By assuming the weld pool surface was a spherical mir­ ror, a reflection model was established to calculate the surface height (SH) index based on the measurement of the DERI, arc length, and weld pool geometry. The pro­ posed method was verified with bead­on­plate welding experiments. The SH was positively related to the face reinforcement or depression of the weld bead. This method was applied to monitor the penetration state during bead­on­plate autoge­ nous welding, particularly when a complete penetration weld was formed.
Microtubule‐associated defects caused by EFHC1 mutations in juvenile myoclonic epilepsy

Juvenile myoclonic epilepsy (JME) is a common form of epilepsy with a substantial genetic basis to its etiology. While earlier studies have identified EFHC1 as a causative gene for JME, subsequent studies have suggested that ethnicity may play a role in determining expression of the JME phenotype among individuals carrying EFHC1 mutations. Here, we report on our studies on EFHC1 in JME patients from India. We examined the complete structure of the EFHC1 transcript from 480 JME patients and 700 control chromosomes by direct sequencing. Functional correlates of mutations were studied by immunolocalization experiments in cultured mammalian cells and protein homology modeling by in silico methods. Thirteen mutations, of which 11 were previously not known, were identified in 28 JME patients. These mutations accounted for about 6% of the patients examined. Functional studies suggest that these EFHC1 mutations result in microtubule‐related abnormalities during cell division. In silico analysis for a subset of mutations suggests that they may affect EFHC1 protein domains, compromising its ability to interact with other proteins. Our observations strengthen the evidence supporting a role for EFHC1 in JME in a population ethnically and geographically distinct from the one in which the gene was initially identified, and broaden the extent of allelic heterogeneity in the gene.
Quality of the forage apparently consumed by beef calves in natural grassland under fertilization and oversown with cool season forage species

The objective of this study was to evaluate the chemical composition of the forage apparently consumed by steers in a natural grassland on region of Campanha, in Rio Grande do Sul, Brazil, subjected or not to different inputs: NP - natural pasture without inputs; FNP - fertilized natural pasture and INP - improved natural grassland with fertilization and over-seeded with cultivated winter species. Three Angus steers testers and a variable number of regulator animals per experimental unit were utilized in order to maintain 13 kg of DM/100 kg of live weight (LW) as forage allowance. One time at each season, hand plucking samples were performed along the daily grazing time simulating forage harvested by the animals. The collected samples after drying and grind were submitted to chemical analysis to determine the forage quality. Except in winter and spring, the values of neutral detergent fiber were higher than the critical value of 550 g/kg of DM, which could limit forage intake, demonstrating that the values of forage on offer provided (15.6; 13.7; 13.5; 15.8 kg of DM/100 kg of LW/day in summer, autumn, winter and spring, respectively) were not restrictive to intake. The oversowing of winter cultivated species or fertilization positively alter the degradable fiber content. The seasons had marked influence on the chemical composition of forage apparently consumed; positively increasing some fractions of forage chemical composition in the seasons in which native or cultivated winter species increased their participation. The forage chemical composition is the determining factor in animal performance in natural pasture.
Workflow and factors associated with delay in the delivery of intra-arterial treatment for acute ischemic stroke in the MR CLEAN trial

Objective The effect of intra-arterial treatment (IAT) for acute ischemic stroke is highly time-dependent. We investigated the delay of IAT and factors associated with such delay. Methods MR CLEAN was a randomized trial of IAT plus usual care versus usual care alone (n=500). With multivariable linear regression, we analyzed the effect of intravenous treatment, general anesthesia, off-hours and inter-hospital transfer on time to admission to the emergency department (ED) of the intervention center and time to treatment. Furthermore, we assessed compliance with a target of 75 min for time from ED to treatment, and calculated the potential absolute increase in the number of patients with a good outcome (modified Rankin Scale score ≤2) if this target had been achieved in all treated patients. Results Inter-hospital transfer prolonged time to ED by 140 min (95% CI 129 to 150) but reduced time from ED to treatment by 77 min (95% CI 64 to 91). Time from ED to treatment was increased by 19 min by general anesthesia (95% CI 5 to 33) and total time was increased by 23 min during off-hours (95% CI 6 to 40). The in-hospital target was achieved in 11.5% (22/192) of patients. Full compliance with the target time of 75 min from ED to treatment would have increased the proportion of patients with a good outcome by 7.6% (95% CI 6.7% to 8.5%). Conclusion Inter-hospital transfer is an important cause of delay in the delivery of IAT and every effort should be made to avoid transfers and reduce transfer-related delay. Furthermore, in-hospital workflow should be optimized to improve functional outcome after IAT.
RESPONSE TO LOAD FOR FOUR DIFFERENT BORED PILES

Four strain-gage instrumented bored piles were constructed in a sedimentary, dense to very dense, fine to medium sand in Santa Cruz, Bolivia. Two of the test piles were the normally used bored pile constructed with bentonite slurry and two piles were Bauer Full Displacement Pile (FDP). One of each pair was equipped with the Expander Body, an inflatable steel cylinder that on pressure-grouting provides an enlarged pile toe. Head-down static loading test were performed on three of the piles and a bidirectional test was performed on the fourth pile, a standard pile with Expander Body and a bidirectional cell placed immediately above the EB. The latter pile was tested in 3 phases. First by activating the cell, second, by a head-down test, and, third, by a repeat bidirectional cell test. The static loading tests proved the shaft resistance of the FDP pile to be about twice that of the standard bored pile and that the Expander Body more than doubled the toe stiffness. The strain-gage records showed that the standard bored piles had multiple bulges and neckings, which affected the evaluation of the axial stiffness and load distribution of the piles. The testing programme was used for a prediction event with 60 persons, ahead of the tests, submitting predictions of the load-movement curves for the test piles and also a capacity appraised from the curves.
Consistency of Lipschitz learning with infinite unlabeled data and finite labeled data

We prove that Lipschitz learning on graphs is consistent with the absolutely minimal Lipschitz extension problem in the limit of infinite unlabeled data and finite labeled data. In particular, we show that the continuum limit is independent of the distribution of the unlabeled data, which suggests the algorithm is fully supervised (and not semi- supervised) in this setting. We also present some new ideas for modifying Lipschitz learning to incorporate the distribution of the unlabeled data.
Specialization of the paralogue LYS 21 determines lysine biosynthesis under respiratory metabolism in Saccharomyces cerevisiae

Correspondence Alicia González amanjarr@ifc.unam. mx Departamento de Genética Molecular, Instituto de Fisiologı́a Celular, Universidad Nacional Autónoma de México, Apartado Postal 70-242, México DF 04510, México Laboratorio de Fisicoquı́mica e Ingenierı́a de Proteı́nas, Departamento de Bioquı́mica, Facultad de Medicina, Universidad Nacional Autónoma de México, México DF 04510, México Instituto Nacional de Cardiologı́a, Departamento de Bioquı́mica, Tlalpan, México DF, México
Capital Allocation and Productivity in South Europe

Following the introduction of the euro in 1999, countries in the South experienced large capital inflows and low productivity. We use data for manufacturing firms in Spain to document a significant increase in the dispersion of the return to capital across firms, a stable dispersion of the return to labor across firms, and a significant increase in productivity losses from misallocation over time. We develop a model of heterogeneous firms facing financial frictions and investment adjustment costs. The model generates cross-sectional and time-series patterns in size, productivity, capital returns, investment, and debt consistent with those observed in production and balance sheet data. We illustrate how the decline in the real interest rate, often attributed to the euro convergence process, leads to a decline in sectoral total factor productivity as capital inflows are misallocated toward firms that have higher net worth but are not necessarily more productive. We conclude by showing that similar trends in dispersion and productivity losses are observed in Italy and Portugal but not in Germany, France, and Norway.
Hydrogen-related Issues in GaAs Schottky Contacts

The characteristics of GaAs Schottky diodes have been discussed in relation to hydrogen-related issues. The surface subjected to atomic hydrogen would be cove r ed with Ga droplets, and the Schottky contacts fabricated on such a surface becomes inhomogeneous. In plasma processing with hyd rogen and/or hydride gases, the induced near-surface defects provide positive charges (dono rtype defects) regardless of the substrate conductivity type, and significantly modify the effective Schottky barrier height. The estimated built-in-voltage would become larger than the real one due to hydrogen passivation of dopants, and hence the r lationship of SBH C-V > SBH I-V is observed.
Noninvasive Ventilation in Obese Subjects After Acute Respiratory Failure

INTRODUCTION: Noninvasive ventilation (NIV) has been widely used to treat acute respiratory failure in obese patients. Criteria that could help clinicians to decide whether they should continue to use NIV after such an initial episode remain unclear. Our retrospective study aims to analyze characteristics of subjects receiving long-term NIV after an initial hospitalization for acute respiratory failure. METHODS: From January 2011 to December 2012, 77 obese adults were admitted in the ICU of the respiratory disease department in Nantes University Hospital in France. After discharge, adherence, body mass index (BMI), and arterial blood gases were assessed or measured at 6 months and 12 months. RESULTS: In all, 53 subjects were analyzed, including 62% who were admitted for idiopathic acute hypercapnic respiratory failure. Mean BMI was 42 ± 11 kg/m2. Failure of NIV occurred in 10% cases in the ICU. At the end of the hospital stay, 34 subjects were discharged with NIV at home. They had higher BMI and higher initial inspiratory positive airway pressure than those who were not ventilated at home. During follow-up, BMI, PaCO2, and bicarbonate rate significantly decreased. At 12 months, 4 subjects were not ventilated anymore after a mean duration of 6 ± 4.2 months of ventilation. Adherence was correct in 86%, with a mean use of 7 ± 3.1 h/d. Adherent subjects had better adherence at 1 month, a lower forced vital capacity, a higher bicarbonate rate, and a higher NIV breathing frequency when compared to subjects with poor adherence. CONCLUSIONS: Subjects with the most severe obesity or who experienced the most difficult initial ventilation were more likely to receive long-term NIV after initial management of acute respiratory failure in the ICU. In those subjects, long-term NIV at home was effective and well tolerated.
0 Bit-Precise Procedure-Modular Termination Analysis

Hong-Yi Chen, Department of Computer Science, University of Oxford, United Kingdom Cristina David, Department of Computer Science, University of Oxford, United Kingdom Daniel Kroening, Department of Computer Science, University of Oxford, United Kingdom Peter Schrammel, School of Engineering and Informatics, University of Sussex, United Kingdom Björn Wachter, SSW-Trading GmbH, Oststeinbek, Germany
3D G-CNNs for Pulmonary Nodule Detection

Convolutional Neural Networks (CNNs) require a large amount of annotated data to learn from, which is often difficult to obtain in the medical domain. In this paper we show that the sample complexity of CNNs can be significantly improved by using 3D roto-translation group convolutions (G-Convs) instead of the more conventional translational convolutions. These 3D G-CNNs were applied to the problem of false positive reduction for pulmonary nodule detection, and proved to be substantially more effective in terms of performance, sensitivity to malignant nodules, and speed of convergence compared to a strong and comparable baseline architecture with regular convolutions, data augmentation and a similar number of parameters. For every dataset size tested, the G-CNN achieved a FROC score close to the CNN trained on ten times more data.
The rs7903146 Variant in the TCF7L2 Gene Increases the Risk of Prediabetes/Type 2 Diabetes in Obese Adolescents by Impairing β-Cell Function and Hepatic Insulin Sensitivity

OBJECTIVE In this study, we aimed to explore the mechanism by which TCF7L2 rs7903146 risk allele confers susceptibility to impaired glucose tolerance (IGT) or type 2 diabetes (T2D) in obese adolescents. RESEARCH DESIGN AND METHODS The rs7903146 variant in the TCF7L2 gene was genotyped in a multiethnic cohort of 955 youths. All subjects underwent an oral glucose tolerance test with the use of the Oral Minimal Model to assess insulin secretion, and 33 subjects underwent a hyperinsulinemic-euglycemic clamp. In 307 subjects, a follow-up oral glucose tolerance test was repeated after 3.11 ± 2.36 years. RESULTS The TCF7L2 rs7903146 risk allele was associated with higher 2-h glucose levels in Caucasians (P = 0.006) and African Americans (P = 0.009), and a trend was seen also in Hispanics (P = 0.072). Also, the T allele was associated with decreased β-cell responsivity and IGT (P < 0.05). Suppression of endogenous hepatic glucose production was lower in subjects with the risk variant (P = 0.006). Finally, the odds of showing IGT/T2D at follow-up were higher in subjects carrying the minor allele (odds ratio 2.224; 95% CI 1.370–3.612; P = 0.0012). CONCLUSIONS The rs7903146 variant in the TCF7L2 gene increases the risk of IGT/T2D in obese adolescents by impairing β-cell function, and hepatic insulin sensitivity predicts the development of IGT/T2D over time.
Pharmacology in translation: the preclinical and early clinical profile of the novel α2/3 functionally selective GABAA receptor positive allosteric modulator PF‐06372865

Benzodiazepines, non‐selective positive allosteric modulators (PAMs) of GABAA receptors, have significant side effects that limit their clinical utility. As many of these side effects are mediated by the α1 subunit, there has been a concerted effort to develop α2/3 subtype‐selective PAMs.
SHEAR STRENGTH OF REINFORCED CONCRETE T-BEAMS WITHOUT STIRRUPS

This paper presents the test results of experimental study on shear strength of reinforced concrete beams without stirrups. The test variables in this study were type of beam cross section and ratio of longitudinal reinforcement. Six simple supported beams, consisting of three beams with rectangular cross section and three beams with T section, subjected to two point load were tested until failure. During the test, the values of the diagonal crack load and the maximum load were observed as well as the deformation of the beams. Existing empirical equations for shear strength of concrete presented in the literature and design codes were used and then compared to that value obtained from the test. Comparison between test results and theoretical shear capacity show that all of equations conservatively estimate the occurrence of shear failure with the values of the test results 10 to 90% higher than the theoretical values. It was confirmed from the test that the shear capacity of T-beams were higher than for rectangular beams, with the values ranging from 5 to 25%, depending on the ratio of longitudinal reinforcement. Also, it was observed that ratio of longitudinal reinforcement influences the shear capacity of the beam as well as the angle of diagonal shear crack. In addition, based on the test results, a simple model for predicting the contribution of flange to shear capacity in T-beam was presented.
Host‐induced silencing of essential genes in Puccinia triticina through transgenic expression of RNAi sequences reduces severity of leaf rust infection in wheat

Summary Leaf rust, caused by the pathogenic fungus Puccinia triticina (Pt), is one of the most serious biotic threats to sustainable wheat production worldwide. This obligate biotrophic pathogen is prevalent worldwide and is known for rapid adaptive evolution to overcome resistant wheat varieties. Novel disease control approaches are therefore required to minimize the yield losses caused by Pt. Having shown previously the potential of host‐delivered RNA interference (HD‐RNAi) in functional screening of Pt genes involved in pathogenesis, we here evaluated the use of this technology in transgenic wheat plants as a method to achieve protection against wheat leaf rust (WLR) infection. Stable expression of hairpin RNAi constructs with sequence homology to Pt MAP‐kinase (PtMAPK1) or a cyclophilin (PtCYC1) encoding gene in susceptible wheat plants showed efficient silencing of the corresponding genes in the interacting fungus resulting in disease resistance throughout the T2 generation. Inhibition of Pt proliferation in transgenic lines by in planta‐induced RNAi was associated with significant reduction in target fungal transcript abundance and reduced fungal biomass accumulation in highly resistant plants. Disease protection was correlated with the presence of siRNA molecules specific to targeted fungal genes in the transgenic lines harbouring the complementary HD‐RNAi construct. This work demonstrates that generating transgenic wheat plants expressing RNAi‐inducing transgenes to silence essential genes in rust fungi can provide effective disease resistance, thus opening an alternative way for developing rust‐resistant crops.
On Pinning Synchronization of Directed and Undirected Complex Dynamical Networks

This paper presents some low-dimensional pinning criteria for global synchronization of both directed and undirected complex networks, and proposes specifically pinning schemes to select pinned nodes by investigating the relationship among pinning synchronization, network topology, and the coupling strength. The paper answers the challenging questions in pinning control of complex networks: 1) what sufficient conditions can guarantee global asymptotic stability of the pinning process; 2) what nodes should be chosen as pinned candidates; and 3) how many nodes are needed to be pinned for a fixed coupling strength? Furthermore, an adaptive pinning control scheme is developed to achieve synchronization of general complex networks. Numerical examples are given to verify our theoretical analysis.
The effects of particle size, shape, density and flow characteristics on particle margination to vascular walls in cardiovascular diseases

ABSTRACT Introduction: Vascular-targeted drug delivery is a promising approach for the treatment of atherosclerosis, due to the vast involvement of endothelium in the initiation and growth of plaque, a characteristic of atherosclerosis. One of the major challenges in carrier design for targeting cardiovascular diseases (CVD) is that carriers must be able to navigate the circulation system and efficiently marginate to the endothelium in order to interact with the target receptors. Areas covered: This review draws on studies that have focused on the role of particle size, shape, and density (along with flow hemodynamics and hemorheology) on the localization of the particles to activated endothelial cell surfaces and vascular walls under different flow conditions, especially those relevant to atherosclerosis. Expert opinion: Generally, the size, shape, and density of a particle affect its adhesion to vascular walls synergistically, and these three factors should be considered simultaneously when designing an optimal carrier for targeting CVD. Available preliminary data should encourage more studies to be conducted to investigate the use of nano-constructs, characterized by a sub-micrometer size, a non-spherical shape, and a high material density to maximize vascular wall margination and minimize capillary entrapment, as carriers for targeting CVD.
Coordination and trade-offs among hydraulic safety, efficiency and drought avoidance traits in Amazonian rainforest canopy tree species.

Predicting responses of tropical forests to climate change-type drought is challenging because of high species diversity. Detailed characterization of tropical tree hydraulic physiology is necessary to evaluate community drought vulnerability and improve model parameterization. Here, we measured xylem hydraulic conductivity (hydraulic efficiency), xylem vulnerability curves (hydraulic safety), sapwood pressure-volume curves (drought avoidance) and wood density on emergent branches of 14 common species of Eastern Amazonian canopy trees in Paracou, French Guiana across species with the densest and lightest wood in the plot. Our objectives were to evaluate relationships among hydraulic traits to identify strategies and test the ability of easy-to-measure traits as proxies for hard-to-measure hydraulic traits. Xylem efficiency was related to capacitance, sapwood water content and turgor loss point, and other drought avoidance traits, but not to xylem safety (P50 ). Wood density was correlated (r = -0.57 to -0.97) with sapwood pressure-volume traits, forming an axis of hydraulic strategy variation. In contrast to drier sites where hydraulic safety plays a greater role, tropical trees in this humid tropical site varied along an axis with low wood density, high xylem efficiency and high capacitance at one end of the spectrum, and high wood density and low turgor loss point at the other.
Bridging Gender Gaps? The Rise and Deceleration of Female Labor Force Participation in Latin America: An overview

This book contributes to the understanding of female labor force participation in Latin America by documenting the changes that took place over the last two decades, exploring their determinants, analyzing their consequences on labor and social outcomes, and discussing implications for public policy. The book highlights a potentially worrisome finding: after around half a century of sustained growth, there are signs of a widespread and significant deceleration in the entry of women into the Latin American labor markets. A version of this paper will be published as Chapter 1 of Gasparini and Marchionni (eds.) (2015). Bridging gender gaps? The rise and deceleration of female labor force participation in Latin America.