Miracle-dz/UniFAR-FTUs huggingface dataset:
A Filamentary Structure of Massive Star-forming Galaxies Associated with an X-Ray-absorbed QSO at z = 1.8

The genesis of spheroids is central to our understanding of galaxy formation: they are relatively simple systems, containing about half the stellar mass of the universe. A major subset of spheroids, massive elliptical galaxies, are preferentially found in clusters where they exhibit old coeval stellar populations suggesting that they formed synchronously at early epochs. Here we report Submillimeter Common-User Bolometric Array submillimeter imaging of a region around a z = 1.8 X-ray-selected QSO. The image reveals a remarkable ~400 kpc long chain of galaxies, each with an obscured star formation rate sufficiently high to build a massive spheroid in less than 1 Gyr. The large overdensity of these galaxies relative to expectations for a random field implies that they probably reside in a structure associated with the QSO. We suggest that this star formation is associated with galaxy mergers or encounters within the filament, such as those predicted by the popular hierarchical model of galaxy formation. Our observations suggest that strong absorption in the X-ray spectra of QSOs at high redshifts may result from a veil of gas thrown up by a merger or merger-induced activity, rather than an orientation-dependent obscuring torus. It is argued that these systems are the precursors of elliptical galaxies found today in the core regions of all rich galaxy clusters.
Changes in mental well-being during Minnesota treatment

The present study assessed mental well-being daily in 28 alcohol-dependent patients who underwent 28 days of Minnesota inpatient treatment. The Swedish Mood Adjective Check List (sMACL) with six bipolar dimensions was used for daily self-reports. At start of treatment, patients had lower levels in four dimensions of mental well-being compared to those of a norm group. Moreover, patients showed significant improvements in all levels of mental well-being during treatment, and at the end of treatment patients had values within the normal range, except for one dimension (activation/deactivation), in which the levels were significantly higher. The findings may suggest a beneficial effect of this type of treatment on mental well-being, although findings may also reflect a mere effect of adjustment to treatment or the social situation.
Diasporas in the New Media Age: Identity, Politics, and Community

The explosion of digital information and communication technologies has influenced almost every aspect of contemporary life. "Diasporas in the New Media Age" is the first book-length examination of the social use of these technologies by emigrants and diasporas around the world. The eighteen original essays in the book explore the personal, familial, and social impact of modern communication technology on populations of European, Asian, African, Caribbean, Middle Eastern, and Latin American emigrants. It also looks at the role and transformation of such concepts as identity, nation, culture, and community in the era of information technology and economic globalization. The contributors, who represent a number of disciplines and national origins, also take a range of approaches - empirical, theoretical, and rhetorical - and combine case studies with thoughtful analysis. "Diasporas in the New Media Age" is both a discussion of the use of communication technologies by various emigrant groups and an engaging account of the immigrant experience in the contemporary world. It offers important insights into the ways that dispersed populations are using digital media to maintain ties with their families and homeland, and to create new communities that preserve their culture and reinforce their sense of identity. In addition, the book is a significant contribution to our understanding of the impact of technology on society in general.
Mental health and criminal justice : a review of the relationship between mental disorders and offending behaviours and on the management of mentally abnormal offenders in the health and criminal justice services

This paper considers the current state of knowledge, research priorities and policy implications of the relationship between offending behaviour and major mental disorder, intellectual disability, brain damage and neurological disorders including epilepsy, and substance abuse; the methodological limitations of existing studies; effect size and practical significance; the step from associations to risks, and from risks to predictions; the influences of changing patterns of mental health care service delivery and the burgeoning prison population; managing mental disorders in the criminal justice system; and managing the risk of future offending among the mentally disordered in the mental health services. The report includes a number of appendices, which mostly consist of articles reprinted from other publications. Most of these are not included in the online version of the report.
HLA-DQB1*0201 homozygosis predisposes to severe intestinal damage in celiac disease

Objective. Celiac disease (CD) is a T-lymphocyte-mediated small intestinal enteropathy triggered and maintained by dietary gluten, with a strong genetic component mapping to the HLA genes encoding for the class II DQ(α1*0501, β1*02) molecule. Damage of the small intestine may cause a variety of clinical signs ranging from isolated long-standing iron-deficiency anemia refractory to iron supplementation to forms of severe malnutrition that may become life threatening. However, patients carrying the typical intestinal lesions of CD and presenting no symptoms at all (silent CD) are also a common clinical observation. Since it is commonly assumed that clinical signs and symptoms tend to correlate with the severity of the intestinal damage, the purpose of this study was to investigate whether particular HLA class II genotypes might also influence the extent of intestinal damage and consequently the clinical presentation of the disease. Material and methods. We retrospectively compared histological grading of celiac disease intestinal biopsies with HLA haplotype, age at onset of disease and clinical signs and symptoms. Results. Our findings showed that homozygosis for the DQB1*0201 allele is associated with a higher severity of the histological score (p<0.008). Of note for the clinician, this work also suggests that the same type 3c of intestinal damage causes a different clinical syndrome, depending on the patient's age. Conclusions. The genetic predisposition at the HLA-DQB1 locus influences the severity of the mucosal damage in a dose-dependent manner, but not the clinical presentation, of celiac disease.
Epigenetic‐mediated immune suppression of positive co‐stimulatory molecules in chemoresistant ovarian cancer cells

The immunological response against cancer is a critical balance between immune‐activating and immune‐suppressing mechanisms. Ovarian cancer creates a suppressive microenvironment to escape immune elimination; however, the molecular mechanisms are poorly understood, and it is unclear whether chemotherapeutic drugs exert an immunoreactive or immunosuppressive effect on the tumor microenvironment. 4‐1BB ligand (4‐1BBL/CD157) and OX‐40 ligand (OX‐40L/CD252) are important regulators of effector cytotoxic T‐cells activity. This study demonstrates that expression of positive co‐stimulatory molecules, OX‐40L and 4‐1BBL, is suppressed while expression of immunosuppressive molecule programmed death ligand‐1 (PD‐L1/CD274) is enhanced in chemoresistant cells compared to parental chemosensitive ovarian cancer cells. Here, the molecular mechanisms of silencing of OX‐40L and 4‐1BBL expression were investigated in chemoresistant A2780‐AD ovarian cancer cells. The suppression of OX‐40L and 4‐1BBL are due to DNA hypermethylation and histone deacetylation, two important mechanisms that contribute to gene silencing during cancer progression. We identify important epigenetic regulators, histone deacetylase 1/3 (HDAC1/HDAC3) and DNA methyltransferase 1 (DNMT1), that exhibit aberrant association with OX‐40L and 4‐1BBL promoters in chemoresistant ovarian cancer cells. Knockdown of HDAC1 or DNMT1 expression, and pharmacological inhibition of DNMT or HDAC enzymatic activity, significantly increase OX‐40L and 4‐1BBL expression in chemoresistant cells. This study suggests that loss of histone acetylation and accumulation of DNA methylation correlates with suppressed expression of OX‐40L and 4‐1BBL in chemoresistant ovarian cancer cells. This study marks the first report of the regulation of these two molecules by histone deacetylation and DNA methylation in chemoresistant ovarian cancer cells.
Mental illness and warfarin use in atrial fibrillation.

OBJECTIVES To determine whether atrial fibrillation (AF) patients with mental health conditions (MHCs) were less likely than AF patients without MHCs to be prescribed warfarin and, if receiving warfarin, to maintain an International Normalized Ratio (INR) within the therapeutic range. STUDY DESIGN Detailed chart review of AF patients using a Veterans Health Administration (VHA) facility in 2003. METHODS For a random sample of 296 AF patients, records identified clinician-diagnosed MHCs (independent variable) and AF-related care in 2003 (dependent variables), receipt of warfarin, INR values below/above key thresholds, and time spent within the therapeutic range (2.0-3.0) or highly out of range. Differences between the MHC and comparison groups were examined using X2 tests and logistic regression controlling for age and comorbidity. RESULTS Among warfarin-eligible AF patients (n = 246), 48.5% of those with MHCs versus 28.9% of those without MHCs were not treated with warfarin (P = .004). Among those receiving warfarin and monitored in VHA, highly supratherapeutic INRs were more common in the MHC group; for example, 27.3% versus 1.6% had any INR >5.0 (P <.001). Differences persisted after adjusting for age and comorbidity. CONCLUSIONS MHC patients with AF were less likely than those without MHC to have adequate management of their AF care. Interventions directed at AF patients with MHC may help to optimize their outcomes.
Inhibition of growth of Mycobacterium avium in murine and human mononuclear phagocytes by migration inhibitory factor

Infections caused by Mycobacterium avium, the most common form of diseminated bacterial disease in AIDS patients, are difficult to treat because of their resistance to many antimycobacterial drugs. The results of the present study show that recombinant migration inhibitory factor, a 12-kDa molecule recently isolated by COS-1 cell expression screening of cDNA from a human T-cell hybridoma, has potent inhibitory activity on the growth of a panel of clinical isolates of M. avium within both bone-marrow-derived murine macrophages and cultured human blood monocytes. These cells cultured in recombinant migration inhibitory factor exhibit various signs of activation, including cell division, morphological changes such as evidence of substantial phagolysosomal fusion, and enhanced secretion of tumor necrosis factor.
Impact of Wireless Electronic Medical Record System on the Quality of Patient Documentation by Emergency Field Responders during a Disaster Mass-Casualty Exercise

Abstract Introduction: The use of wireless, electronic, medical records and communications in the prehospital and disaster field is increasing. Objective: This study examines the role of wireless, electronic, medical records and communications technologies on the quality of patient documentation by emergency field responders during a mass-casualty exercise. Methods: A controlled, side-to-side comparison of the quality of the field responder patient documentation between responders utilizing National Institutes of Health-funded, wireless, electronic, field, medical record system prototype (“Wireless Internet Information System for medicAl Response to Disasters” or WIISARD) versus those utilizing conventional, paper-based methods during a mass-casualty field exercise. Medical data, including basic victim identification information, acuity status, triage information using Simple Triage and Rapid Treatment (START), decontamination status, and disposition, were collected for simulated patients from all paper and electronic logs used during the exercise. The data were compared for quality of documentation and record completeness comparing WIISARD-enabled field responders and those using conventional paper methods. Statistical analysis was performed with Fisher’s Exact Testing of Proportions with differences and 95% confidence intervals reported. Results: One hundred simulated disaster victim volunteers participated in the exercise, 50 assigned to WIISARD and 50 to the conventional pathway. Of those victims who completed the exercise and were transported to area hospitals, medical documentation of victim START components and triage acuity were significantly better for WIISARD compared to controls (overall acuity was documented for 100% vs 89.5%, respectively, difference = 10.5% [95%CI = 0.5–24.1%]). Similarly, tracking of decontamination status also was higher for the WIISARD group (decontamination status documented for 59.0% vs 0%, respectively, difference = 9.0% [95%CI = 40.9–72.0%]). Documentation of disposition and destination of victims was not different statistically (92.3% vs. 89.5%, respectively, difference = 2.8% [95%CI = -11.3–17.3%]). Conclusions: In a simulated, mass-casualty field exercise, documentation and tracking of victim status including acuity was significantly improved when using a wireless, field electronic medical record system compared to the use of conventional paper methods.
Feature saliency and feedback information interactively impact visual category learning

Visual category learning (VCL) involves detecting which features are most relevant for categorization. VCL relies on attentional learning, which enables effectively redirecting attention to object’s features most relevant for categorization, while ‘filtering out’ irrelevant features. When features relevant for categorization are not salient, VCL relies also on perceptual learning, which enables becoming more sensitive to subtle yet important differences between objects. Little is known about how attentional learning and perceptual learning interact when VCL relies on both processes at the same time. Here we tested this interaction. Participants performed VCL tasks in which they learned to categorize novel stimuli by detecting the feature dimension relevant for categorization. Tasks varied both in feature saliency (low-saliency tasks that required perceptual learning vs. high-saliency tasks), and in feedback information (tasks with mid-information, moderately ambiguous feedback that increased attentional load, vs. tasks with high-information non-ambiguous feedback). We found that mid-information and high-information feedback were similarly effective for VCL in high-saliency tasks. This suggests that an increased attentional load, associated with the processing of moderately ambiguous feedback, has little effect on VCL when features are salient. In low-saliency tasks, VCL relied on slower perceptual learning; but when the feedback was highly informative participants were able to ultimately attain the same performance as during the high-saliency VCL tasks. However, VCL was significantly compromised in the low-saliency mid-information feedback task. We suggest that such low-saliency mid-information learning scenarios are characterized by a ‘cognitive loop paradox’ where two interdependent learning processes have to take place simultaneously.
Poly[[diaquadi-μ-dicyanamido-nickel(II)] bis(pyridinium-4-olate)]

The title compound, {[Ni(C2N3)2(H2O)2]·2C5H5NO}n, is a centrosymmetric two-dimensional coordination polymer with a layer (4,4) network structure. The asymmetric unit is compossed of an NiII atom, which sits on an inversion center, a μ-1,5-bridging dicyanamide anion, a water molecule, and a free 4-hydroxypyridine molecule present in the zwitterionic pyridinium-4-olate form. The NiII atom is coordinated in a slightly distorted N4O2 octahedral geometry by four bridging dicyanamide ligands and two trans water molecules. In the crystal, the two-dimensional networks are linked via N—H⋯O and O—H⋯O hydrogen bonds, forming a three-dimensional network.
Phylogenetic relationships in subtribe Poinae (Poaceae, Poeae) based on nuclear ITS and plastid trnT-trnL-trnF sequences

The worldwide temperate subtribe Poinae comprises the largest grass genus, Poa (500+ species), and multiple additional small genera. We explore generic boundaries and relationships among genera of Poinae using nuclear ribosomal internal transcribed spacer data (ITS) and plastid trnT–trnL–trnF (TLF) sequence data. ITS and TLF analyses are mostly congruent with regards to circumscription of genera, and with respect to relationships among Poinae genera, but tree structure is generally better supported among genera in the ITS strict consensus tree. ITS and TLF both support two main Poinae lineages: (i) Poa and (ii) a clade comprising all other sampled Poinae. Nine small genera were nested within the large Poa clade, including Aphanelytrum, Dissanthelium, and Tovarochloa, supporting inclusion of these as sections within Poa. In the second clade, three subclades support close relationships among Nicoraepoa, Hookerochloa, and Arctagrostis; Arctophila and Dupontia; and Apera, Bellardiochloa, and Ventenata. Genera.
Identification of Everyday Objects on the Basis of Fragmented Outline Versions

Although Attneave (1954 Psychological Review 61 183–193) and Biederman (1987 Psychological Review 94 115–147) have argued that curved contour segments are most important in shape perception, Kennedy and Domander (1985 Perception 14 367–370) showed that fragmented object contours are better identifiable when straight segments are shown. We used the set of line drawings published by Snodgrass and Vanderwart (1980 Journal of Experimental Psychology: Human Learning and Memory 6 174–215), to make outline versions that could be used to investigate this issue with a larger and more heterogeneous stimulus set. Fragments were placed either around the ‘salient’ points or around the midpoints (points midway between two salient points), creating curved versus relatively straight fragments when the original outline was fragmented (experiment 1), or angular and straight fragments when straight-line versions were fragmented (experiment 2). We manipulated fragment length in each experiment except the last one, in which we presented only selected points (experiment 3). While fragmented versions were on average more identifiable when straight fragments were shown, certain objects were more identifiable when the curved segments or the angles were shown. A tentative explanation of these results is presented in terms of an advantage for straight segments during grouping processes for outlines with high part salience, and an advantage for curved segments during matching processes for outlines with low part salience.
Early Hearing Detection and Vocabulary of Children With Hearing Loss

The benefits to vocabulary development of meeting current EHDI guidelines are documented in a large, multistate study. BACKGROUND AND OBJECTIVES: To date, no studies have examined vocabulary outcomes of children meeting all 3 components of the Early Hearing Detection and Intervention (EHDI) guidelines (hearing screening by 1 month, diagnosis of hearing loss by 3 months, and intervention by 6 months of age). The primary purpose of the current study was to examine the impact of the current EHDI 1-3-6 policy on vocabulary outcomes across a wide geographic area. A secondary goal was to confirm the impact of other demographic variables previously reported to be related to language outcomes. METHODS: This was a cross-sectional study of 448 children with bilateral hearing loss between 8 and 39 months of age (mean = 25.3 months, SD = 7.5 months). The children lived in 12 different states and were participating in the National Early Childhood Assessment Project. RESULTS: The combination of 6 factors in a regression analysis accounted for 41% of the variance in vocabulary outcomes. Vocabulary quotients were significantly higher for children who met the EHDI guidelines, were younger, had no additional disabilities, had mild to moderate hearing loss, had parents who were deaf or hard of hearing, and had mothers with higher levels of education. CONCLUSIONS: Vocabulary learning may be enhanced with system improvements that increase the number of children meeting the current early identification and intervention guidelines. In addition, intervention efforts need to focus on preventing widening delays with chronological age, assisting mothers with lower levels of education, and incorporating adults who are deaf/hard-of-hearing in the intervention process.
DataTiles: a modular platform for mixed physical and graphical interactions

The DataTiles system integrates the benefits of two major interaction paradigms: graphical and physical user interfaces. Tagged transparent tiles are used as modular construction units. These tiles are augmented by dynamic graphical information when they are placed on a sensor-enhanced flat panel display. They can be used independently or can be combined into more complex configurations, similar to the way language can express complex concepts through a sequence of simple words. In this paper, we discuss our design principles for mixing physical and graphical interface techniques, and describe the system architecture and example applications of the DataTiles system.
The Role of Angiogenesis in the Development of Proliferative Diabetic Retinopathy: Impact of Intravitreal Anti-VEGF Treatment

Although cellular and molecular bases of proliferative diabetic retinopathy are only partially understood, it is evident that this complication of diabetes is characterized by the formation of new vessels inside the retina showing abnormal architecture and permeability. This process, if not controlled by selective laser photocoagulation, leads to irreversible retinal damages and loss of vision. Angiogenesis, that is, the condition characterized by the growth of new blood vessels originated from preexisting ones, was shown to have a major role in the pathogenesis of proliferative retinopathy and, as a consequence, intravitreal antiangiogenic injection was suggested as a feasible treatment for this disease. Here, we describe the different antiangiogenic approaches used to treat this disease along with the respective advantages and limitations when compared to laser treatment. Altogether, even though further and longer studies are still needed to clarify the best possible therapeutic protocol, the antiangiogenic treatment will reasonably have a future role in the therapy and prevention of proliferative diabetic retinopathy.