Miracle-dz/UniFAR-FTUs huggingface dataset:
Proficiency modulates early orthographic and phonological processing in L2 spoken word recognition

The present study investigated orthographic and phonological processing in L2 French spoken word recognition by Finnish learners of French, using the masked cross-modal priming paradigm. Experiment 1 showed a repetition effect in L2 within-language priming that was most pronounced for high proficiency learners and a significant effect for French pseudohomophones. In the between-language Experiment 2, high proficiency learners showed significant facilitation from L1 Finnish to L2 French shared orthography in the absence of phonological and semantic overlap. This effect was not observed in the lower intermediate group, which showed a significant benefit of L1 pseudohomophones instead. The orthographic effect in the high proficiency group was modulated by subjective familiarity showing facilitation for less familiar but not for highly familiar words. The results suggest that with L2 learners, the extent to which orthographic information affects L2 spoken word recognition depends on their L2 proficiency.
Psychophysiological and learning correlates of anxiety and induced muscle relaxation.

Recently, extensive use has been made of voluntary muscle relaxation as a response which presumably inhibits anxiety in “systematic desensitization” psychotherapies. This study attempted to test the hypothesis that muscle relaxation would reciprocally inhibit anxiety during a paired-associate learning task. Subjects (Ss) were divided into high, medium, and low anxiety levels and muscle tension, muscle relaxation, and normal tension groups. Paired-associate learning efficiency, as well as heart rate, skin conductance, integrated electromyogram, respiration rate, and finger temperature during learning were measured. Partial substantiation for the hypothesis was obtained for high anxiety Ss, but data for other groups was inconsistent with the hypothesis. An alternative explanation was suggested. Heart rate was the physiological variable which best discriminated the groups.
Exploring the Components of Career Well-Being and the Emotions Associated with Significant Career Experiences

This study aimed to identify the main features of career well-being and the emotions people experience as they navigate their careers. Data from 89 individuals working in various occupations suggested seven features of career well-being involving the following: career transitions, interpersonal relationships, relationship with the organization, work performance, sense of purpose, learning and development, and work—life issues. Fifteen positive and 24 negative emotions were reported, and several career experiences were associated with wide-ranging emotions. Moving to a new role was particularly likely to involve a mixture of positive and negative emotions. Participants frequently gave examples of interpersonal difficulties as negative career experiences, and these sometimes led to profound feelings of unhappiness and worthlessness. Implications for career counseling and career management are discussed.
Consensus paper of the WFSBP Task Force on Biological Markers: Biological Markers in Depression

Biological markers for depression are of great interest to aid in elucidating the causes of major depression. We assess currently available biological markers to query their validity for aiding in the diagnosis of major depression. We specifically focus on neurotrophic factors, serotonergic markers, biochemical markers, immunological markers, neuroimaging, neurophysiological findings, and neuropsychological markers. We delineate the most robust biological markers of major depression. These include decreased platelet imipramine binding, decreased 5-HT1A receptor expression, increase of soluble interleukin-2 receptor and interleukin-6 in serum, decreased brain-derived neurotrophic factor in serum, hypocholesterolemia, low blood folate levels, and impaired suppression of the dexamethasone suppression test. To date, however, none of these markers are sufficiently specific to contribute to the diagnosis of major depression. Thus, with regard to new diagnostic manuals such as DSM-V and ICD-11 which are currently assessing whether biological markers may be included in diagnostic criteria, no biological markers for major depression are currently available for inclusion in the diagnostic criteria.
A novel de novo missense mutation in TP63 underlying germline mosaicism in AEC syndrome: Implications for recurrence risk and prenatal diagnosis

Ankyloblepharon–ectodermal defects–cleft lip/palate (AEC) syndrome is a rare autosomal dominant ectodermal dysplasia syndrome. It is caused by heterozygous mutations in TP63, encoding a transcriptional factor of the p53 family. Mutations in TP63, mainly missense in exons 13 and 14 encoding the sterile alpha motif (SAM) and the transactivation inhibitory (TI) domains, account for 99% of mutations in individuals with AEC syndrome. Of these, ≥70% are de novo mutations, present in the affected patient, but not in parents nor in healthy siblings. However, when a mutation appears de novo, it is not possible to differentiate between a sporadic mutation, or germline mosaicism in the parents. In this latter case, there is a risk of having additional affected offspring. We describe two sisters with AEC syndrome, whose parents were unaffected. Both patients carried the heterozygous c.1568T>C substitution in exon 13 of TP63, resulting in a p.L523P change in the SAM domain of the protein. Analyses of DNA from parental blood cells, seminal fluid (from the father) and maternal cells (buccal, vaginal, and cervical) did not reveal the mutation, suggesting that the mosaicism may involve a very low percentage of cells (very low grade somatic mosaicism) or, more likely, maternal gonadal mosaicism. Mosaicism must be considered for the assessment of recurrence risk during genetic counseling in AEC syndrome, and pre‐implantation/prenatal genetic diagnosis should be offered to all couples, even when the mutation is apparently de novo. © 2012 Wiley Periodicals, Inc.
The relations of thalamic connections, cellular structure and evocable electrical activity in the auditory region of the cat

Thalamo-cortical connections were studied in 21 hemispheres by the method of retrograde degeneration. The animals were sacrificed usually 4 weeks after the operation. The brains, embedded in paraffin, were cut horizontally at 20p. The sections were stained with thionin. The cortex surrounding each operative lesion was studied in respect to its cytoarchitecture and the extent of the operative lesion was plotted on the photographs of the respective brains, thus graphically reconstructing the series. Brains of two animals (cats 16 and 18) were plotted on a standard diagram. The
Governing the Governance of Education: The State Strikes Back?

In many countries, there have been changes in the way in which education is governed, with greater fragmentation of responsibility between the state, local government, schools, individuals and the market often accompanied by a move from detailed regulation to framework legislation. Previously, these developments have been seen as part of the move from government to governance whereby the state is forced to step back and allow other interests to play a role. However, in recent years more subtle theories of governance have been developed which argue that, rather than retreating, the state is adapting to changing circumstances and finding new ways of governing. The importance of education not only in terms of creating and maintaining national identity but also for economic development suggests that this is an area from which the state will not willingly abdicate its role. This article suggests that support for the new governance theories can be found in the field of education. It argues that the growth in the attempts to control educational outputs through, for example, demands for quality controls, standardized testing, evaluations and so on and the introduction of national bodies responsible for carrying out these controls can be interpreted as a sign that the state, far from relinquishing its role, is finding other ways of controlling education. A comparative approach is adopted and these ideas are explored in relation to education systems in the Nordic and British countries. The article draws on a qualitative analysis of official policy documents, legislation and official statements concerning education in the respective countries.
Response Agreement Rates Between Child Welfare–Involved Youth and Their Caregivers

ABSTRACT Data were collected from 40 youth and 37 caregivers, which represented 57 distinct youth and 20 youth–caregiver dyads to measure the level of agreement between youth self-report and their caregivers on a variety of topics. Topics included: the youth's past placements, service use and needs, experiences in the child welfare system, and the youth's emotional problems and social behaviors. Results indicated high agreement between youth and caregiver proxy related to placement history, service use, the restrictiveness of the current environment, and community safety; results indicated low levels of agreement for youth emotional difficulties and prosocial behaviors. Qualitative data were used to further identify some of the differences noted. Overall, the findings support prior research that shows higher agreement within youth–caregiver dyads for objective measures as opposed to subjective and private ones. Implications for future research are discussed, and methodological challenges related to this study are identified.
Student‐centred pedagogy in Turkey: conceptualisations, interpretations and practices

The purpose of this article is to explore recent curricular reforms to advocate student‐centred pedagogy (SCP) in primary schools in Turkey. By using a case study approach, the article examines teacher views on SCP, classroom practices and perceived challenges in implementation process. The study highlights some of the unintended consequences of SCP in Turkey (such as parental over‐involvement in performance and research assignments) and discusses a number of issues that seemed to interfere with teachers’ efforts to implement SCP. In line with similar studies in other parts of the world, teachers in Turkey appeared to be concerned with poor teacher training, large classes, material scarcity, examination system, parental opposition and inadequate student responsiveness. The article suggests that instead of focusing on the ‘problematisation’ of implementation process and, in particular, teachers, efforts should be made to develop and apply more structured alternative approaches. While considering promising pedagogical approaches elsewhere, such efforts should also draw more inspiration from Turkish educationalists and scholars in order to develop a more culturally responsive pedagogy, which better suits the social, economic and political realities of Turkish society.
Exploring Mentoring Functions Within the Sport Management Academy: Perspectives of Mentors and Protégés

Mentoring has typically been studied in business environments, with fewer studies focusing on academic contexts and even fewer in the field of sport management. This study examined the mentoring relationships, and specifically the mentoring functions that occurred among sport management doctoral dissertation advisors (mentors) and their doctoral students (proteges). Semistructured telephone interviews were conducted with 13 individuals. Participants collectively described examples of all of Kram’s (1988) mentoring functions, with coaching, counseling, and exposure and visibility cited most frequently. Fewer instances of protection and direct sponsorship were mentioned, although there was evidence of considerable indirect sponsorship. Proteges provided more examples of role modeling as compared with their mentors, and the entire process of completing a doctoral degree can be viewed as a challenging assignment. A discussion of these findings within the context of the relevant previous academic literature an.
Neurodevelopmental disorders in children with neurofibromatosis type 1

Over the past several decades, neurofibromatosis type 1 (NF1) has become increasingly recognized as a neurodevelopmental disorder conferring increased risk for several important neurodevelopmental problems. In this review, we summarize the specific neurodevelopmental problems encountered in the context of NF1. These include impairments in general cognitive function, deficits in specific cognitive domains such as executive function and visuospatial processing and risk for specific learning disorders, impairments in attention and social skills and the overlap with attention‐deficit–hyperactivity disorder and autism spectrum disorder, and the risk of developing other psychiatric conditions including anxiety and depression. Early recognition of these developmental impairments is important for the effective treatment of children with NF1, and further characterization is essential to improve our understanding of how mutations in the NF1 gene create the diversity of clinical neuropsychiatric symptomatology observed in this at‐risk population.
Layered routing in irregular networks

Freedom from deadlock is a key issue in cut-through, wormhole, and store and forward networks, and such freedom is usually obtained through careful design of the routing algorithm. Most existing deadlock-free routing methods for irregular topologies do, however, impose severe limitations on the available routing paths. We present a method called layered routing, which gives rise to a series of routing algorithms, some of which perform considerably better than previous ones. Our method groups virtual channels into network layers and to each layer it assigns a limited set of source/destination address pairs. This separation of traffic yields a significant increase in routing efficiency. We show how the method can be used to improve the performance of irregular networks, both through load balancing and by guaranteeing shortest-path routing. The method is simple to implement, and its application does not require any features in the switches other than the existence of a modest number of virtual channels. The performance of the approach is evaluated through extensive experiments within three classes of technologies. These experiments reveal a need for virtual channels as well as an improvement in throughput for each technology class.
Using FarmVille in an Introductory Managerial Accounting Course to Engage Students, Enhance Comprehension, and Develop Social Networking Skills

This article explores the use of the free Zynga computer game FarmVille, which is played in conjunction with Facebook®, to facilitate active learning in a managerial accounting course. Results indicate that it invokes an improved understanding of the accounting content, particularly among nonaccounting majors; a high level of student satisfaction with the assignment; and excellent outcomes in developing peer-to-peer and faculty–student relationships. This innovative approach is offered as an alternative way to achieve managerial accounting learning objectives. Its greatest strength is the social networking benefits it brings.
Population Structure of Clinical Vibrio parahaemolyticus from 17 Coastal Countries, Determined through Multilocus Sequence Analysis

Vibrio parahaemolyticus is a leading cause of food-borne gastroenteritis worldwide. Although this bacterium has been the subject of much research, the population structure of clinical strains from worldwide collections remains largely undescribed, and the recorded outbreaks of V. parahaemolyticus gastroenteritis highlight the need for the subtyping of this species. We present a broad phylogenetic analysis of 490 clinical V. parahaemolyticus isolates from 17 coastal countries through multilocus sequence analysis (MLST). The 490 tested isolates fell into 161 sequence types (STs). The eBURST algorithm revealed that the 161 clinically relevant STs belonged to 8 clonal complexes, 11 doublets, and 94 singletons, showing a high level of genetic diversity. CC3 was found to be a global epidemic clone of V. parahaemolyticus, and ST-3 was the only ST with an international distribution. recA was observed to be evolving more rapidly, exhibiting the highest degree of nucleotide diversity (0.028) and the largest number of polymorphic nucleotide sites (177). We also found that the high variability of recA was an important cause of differences between the results of the eBURST and ME tree analyses, suggesting that recA has a much greater influence on the apparent evolutionary classification of V. parahaemolyticus based on the current MLST scheme. In conclusion, it is evident that a high degree of genetic diversity within the V. parahaemolyticus population and multiple sequence types are contributing to the burden of disease around the world. MLST, with a fully extractable database, is a powerful system for analysis of the clonal relationships of strains at a global scale. With the addition of more strains, the pubMLST database will provide more detailed and accurate information, which will be conducive to our future research on the population structure of V. parahaemolyticus.
A Practical Approach to Analyzing and Reporting Focus Groups Studies: Lessons from Qualitative Market Research

Market research studies often have a purpose and focus quite different from qualitative health research studies. An appreciation of approaches, techniques for analysis and interpretation, and reporting can broaden the traditional researcher's perspective and may suggest new approaches. This article provides some insights about ways a small and busy qualitative research company analyzes focus group data and prepares reports for clients. Reports are used to support clients in making key decisions that affect organizational programs and policies, and the marketing and advertising of products and services.
SUBSTANCE USER TREATMENT PROGRAM QUALITY: SELECTED TOPICS

This panel explores the “state of the art” in conceptualization and research pertinent to program quality in substance user treatment. First, seven critical questions for program quality are identified and discussed. Second, a recent national evaluation of treatment examines the implications of long-term patient outcomes for treatment quality. Third, a large number of clinical trials of behavioral and pharmacological treatments for cocaine dependence were conducted during the 1990s; this research is synthesized and interpreted. Fourth, progress is reported in improving the quality of treatment through standardized criteria for patient placement matching. Truth seems to come with its final word; and the final word gives birth to its next. Rabindranath Tagore, Stray Birds
Spleen Volume Variation in Patients with Locally Advanced Non-Small Cell Lung Cancer Receiving Platinum-Based Chemo-Radiotherapy

There is renewed interest in the immune regulatory role of the spleen in oncology. To date, very few studies have examined macroscopic variations of splenic volume in the setting of cancer, prior to or during therapy, especially in humans. Changes in splenic volume may be associated with changes in splenic function. The purpose of this study was to investigate variations in spleen volume in NSCLC patients during chemo-radiotherapy. Sixty patients with stage I-IIIB NSCLC underwent radiotherapy (60Gy/30 fractions) for six weeks with concomitant carboplatin/paclitaxel (Ca/P; n = 32) or cisplatin/etoposide (Ci/E; n = 28). A baseline PET/CT scan was performed within 2 weeks prior to treatment and during Weeks 2 and 4 of chemo-radiotherapy. Spleen volume was measured by contouring all CT slices. Significant macroscopic changes in splenic volume occurred early after the commencement of treatment. A significant decrease in spleen volume was observed for 66% of Ca/P and 79% of Ci/E patients between baseline and Week 2. Spleen volume was decreased by 14.2% for Ca/P (p<0.001) and 19.3% for Ci/E (p<0.001) patients. By Week 4, spleen volume was still significantly decreased for Ca/P patients compared to baseline, while for Ci/E patients, spleen volume returned to above baseline levels. This is the first report demonstrating macroscopic changes in the spleen in NSCLC patients undergoing radical chemo-radiotherapy that can be visualized by non-invasive imaging.
The relationship between cognitive functioning and early childhood factors in children with speech and language impairment.

It has long been the quest of developmental theorists to understand the mechanisms behind cognitive functioning and the acquisition of language. Studies have identified that there is an interdependent, dialectical relationship between cognitive development and language acquisition. The development of language, in typical populations, is therefore dependent on a baseline cognitive skill, which, once acquired, capacitates the further development of cognition. However, very little is known about this process within atypical populations, particularly those with speech and language impairment. This study examined the relationship between cognitive functioning and early predictive factors in an atypical population of preschool children with speech and language impairment using three measures of cognitive functioning (as measured by the WPPSI (Wechsler Pre-School and Primary Intelligence Scale), the Griffiths and the JSAIS (Junior South African Individual Scale)) and a range of demographic, diagnostic and early developmental childhood factors. Results identify factors such as parental levels of education, family structure, gender and pregnancy and early childhood health as the main influences of cognitive performance. They also highlight the pervasive influence of speech and language impairment on non-verbal and processing speed abilities. The presence of genetic conditions as well as multiple diagnoses was frequently found to have significant associations with poor cognitive performance. The study also highlighted two things of unexpected interest. The first refers to the role of handedness (particularly undifferentiated handedness) in identifying cognitive difficulty which is related to hemispheric lateralisation, and its relationship to the various diagnostic groups represented within the sample. The second considers the high proportion of diagnostic co-morbidity and the common cognitive profiling patterns across diagnostic categories in abilities outside of the verbal range to highlight potential directions for future research. The implications of these overlaps are considered within existing research on brain laterality, hemispheric dominance and neurological
Nested Lattice Codes for Gaussian Relay Networks With Interference

In this paper, we consider a class of single-source multicast relay networks. We assume that all outgoing channels of a node in the network to its neighbors are orthogonal while the incoming signals from its neighbors can interfere with each other. We first focus on Gaussian relay networks with interference and find an achievable rate using a lattice coding scheme. We show that the achievable rate of our scheme is within a constant bit gap from the information theoretic cut-set bound, where the constant depends only on the network topology, but not on the transmit power, noise variance, and channel gains. This is similar to a recent result by Avestimehr, Diggavi, and Tse, who showed an approximate capacity characterization for general Gaussian relay networks. However, our achievability uses a structured code instead of a random one. Using the idea used in the Gaussian case, we also consider a linear finite-field symmetric network with interference and characterize its capacity using a linear coding scheme.