Miracle-dz/UniFAR-FTUs huggingface dataset:
Neurobiology of food addiction

Purpose of reviewTo review recent work on disorders related to food use, including food addiction, and to highlight the similarities and differences between food and drugs of abuse. Recent findingsRecent work on food use disorders has demonstrated that the same neurobiological pathways that are implicated in drug abuse also modulate food consumption, and that the body's regulation of food intake involves a complex set of peripheral and central signaling networks. Moreover, new research indicates that rats can become addicted to certain foods, that men and women may respond differently to external food cues, and that the intrauterine environment may significantly impact a child's subsequent risk of developing obesity, diabetes, and hypercholesterolemia. SummaryFirst, work presented in this review strongly supports the notion that food addiction is a real phenomenon. Second, although food and drugs of abuse act on the same central networks, food consumption is also regulated by peripheral signaling systems, which adds to the complexity of understanding how the body regulates eating, and of treating pathological eating habits. Third, neurobiological research reviewed here indicates that traditional pharmacological and behavioral interventions for other substance-use disorders may prove useful in treating obesity.
Climate Change and Bark Beetles of the Western United States and Canada: Direct and Indirect Effects

Climatic changes are predicted to significantly affect the frequency and severity of disturbances that shape forest ecosystems. We provide a synthesis of climate change effects on native bark beetles, important mortality agents of conifers in western North America. Because of differences in temperature-dependent life-history strategies, including cold-induced mortality and developmental timing, responses to warming will differ among and within bark beetle species. The success of bark beetle populations will also be influenced indirectly by the effects of climate on community associates and host-tree vigor, although little information is available to quantify these relationships. We used available population models and climate forecasts to explore the responses of two eruptive bark beetle species. Based on projected warming, increases in thermal regimes conducive to population success are predicted for Dendroctonus rufipennis (Kirby) and Dendroctonus ponderosae Hopkins, although there is considerable spatial and temporal variability. These predictions from population models suggest a movement of temperature suitability to higher latitudes and elevations and identify regions with a high potential for bark beetle outbreaks and associated tree mortality in the coming century.
EBV and not HPV sensitizes tobacco-associated head and neck cancer cell line FaDu to radiotherapy

Abstract Conclusion EBV radiosensitized the p53 mutant tobacco associated head and neck cell line, FaDu. Objectives In the head and neck, HPV is a major risk factor associated with tonsil and base of tongue cancers, while a majority of undifferentiated nasopharyngeal cancers are positive for EBV. Clinically, head and neck tumors positive for HPV or EBV are more radiosensitive than tumors associated with tobacco and alcohol. This study aimed to evaluate whether viral infections can sensitize tobacco-associated head and neck squamous cell carcinoma cell line that harbors multiple mutations, especially TP53, to radiotherapy. Method Four FaDu cell lines (vector control – FaDu-DN; FaDu expressing HPV16 E6/E7 – FaDu-HPV; FaDu infected with EBV – FaDu-EBV; and FaDu-HPV infected with EBV – FaDu-HE) were evaluated for their radiation sensitivity using clonogenic assay. Cell cycle, protein expression, apoptosis, and cellular senescence were analyzed. Results FaDu-EBV and FaDu-HE exhibited significantly increased radiosensitivity in comparison with the control cell line. Radiation-induced cell cycle arrest was altered in all cell lines expressing viral genes. The observed distribution of cells at G1 and S phases was associated with a significant increase in expression of p21 protein along with decreased levels of pAKT/AKT and pERK/ERK ratio (p < 0.05) and increased cellular senescence (p < 0.05).
On The Generalized Climbing Stairs Problem

Let $\mathcal S$ be a subset of the positive integers, and $M$ be a positive integer. Mohammad K. Azarian, inspired by work of Tony Colledge, considered the number of ways to climb a staircase containing $n$ stairs using "step-sizes" $s \in \mathcal S$ and multiplicities at most $M$. In this exposition, we find a solution via generating functions, i.e., an expression which counts the number of partitions $n = \sum_{s \in \mathcal S} m_s s$ satisfying $0 \leq m_s \leq M$. We then use this result to answer a series of questions posed by Azarian, thereby showing a link with ten sequences listed in the On-Line Encyclopedia of Integer Sequences. We conclude by posing open questions which seek to count the number of compositions of $n$.
Thirty-two Trends Affecting Distance Education: An Informed Foundation for Strategic Planning

Recent issues in this journal and other prominent distance­learning journals have established the need for administrators to be informed and prepared with strategic plans equal to foreseeable challenges. This article provides decision makers with 32 trends that affect distance learning and thus enable them to plan accordingly. The trends are organized into categories as they pertain to students and enrollment, faculty members, academics, technology, the economy, and distance learning. All the trends were identified during an extensive review of current literature in the field Informed Planning Recent issues in this journal and other prominent distance­learning journals have established the need for administrators to be informed and prepared with strategic plans equal to foreseeable challenges. This article provides decision makers with 32 trends that affect distance learning and thus enable them to plan accordingly. The trends are organized into categories as they pertain to students and enrollment, faculty members, academics, technology, the economy, and distance learning. All the trends were identified during an extensive review of current literature in the field. In a recent issue of Distance Learning Administration, Beaudoin (2003) stressed the importance for institutional leaders “to be informed and enlightened enough to ask fundamental questions that could well influence their institution’s future viability” (p. 1). Example questions included “How many faculty will we be needed in ten years? Will the notion of classrooms survive? Is the present structure of the institution viable? Will teachers and students need to meet on campus anymore? [and] Can the
Ray Tracing Animated Scenes using Motion Decomposition

Though ray tracing has recently become interactive, its high precomputation time for building spatial indices usually limits its applications to walkthroughs of static scenes. This is a major limitation, as most applications demand support for dynamically animated models. In this paper, we present a new approach to ray trace a special but important class of dynamic scenes, namely models whose connectivity does not change over time and for which all possible poses are known in advance.
Group communication in ad-hoc networks: a few results and a case study

In the context of mobile ad-hoc networks, this paper studies the problem of reliable communication among a set of processes forming a group in a dynamic system with an unbounded number of processes. A communication is reliable if any message sent by a member of the group that never leaves or leaves the group in an intentional way is eventually delivered to every member that doesn't leave the group. The problem is studied in a setting where communication links model a temporary disconnection among group members. The paper shows that additional assumptions on the system model are necessary to assure reliable communication. Then it presents a protocol, based on these assumptions, solving the problem in a meeting/conference room application scenario.
Assessment of antibiotic- and disinfectant-resistant bacteria in hospital wastewater, south Ethiopia: a cross-sectional study.

INTRODUCTION Large quantities of antimicrobials are used in hospitals for patient care and disinfection. Antibiotics are partially metabolized and residual quantities reach hospital wastewater, exposing bacteria to a wide range of biocides that could act as selective pressure for the development of resistance. METHODOLOGY A cross-sectional study was conducted between December 2010 and February 2011 on hospital wastewater. A total of 24 composite samples were collected on a weekly basis for bacteriological analysis and susceptibility testing. Indicator organisms and pathogenic and potentially pathogenic bacteria were found and isolated on selective bacteriologic media. Disinfectant activity was evaluated by use-dilution, and minimum inhibitory concentration (MIC) was determined by the agar dilution method. Similarly, antibiotic susceptibility tests were performed using the Kirby-Bauer disk diffusion method. RESULTS Pathogenic (Salmonella, Shigella, and S. aureus) and potentially pathogenic (E. coli) bacteria were detected from effluents of both hospitals. Dilution demonstrated tincture iodine to be the most effective agent, followed by sodium hypochlorite; the least active was 70% ethanol. MIC for ethanol against S. aureus and Gram-negative rods from Yirgalem Hospital (YAH) showed 4 and 3.5 log reduction, respectively. Salmonella isolates from YAH effluent were resistant to ceftriaxone, tetracycline, and doxycycline. Isolates from Hawassa University Referral Hospital (HURH) effluent were resistant to the above three antibiotics as well as gentamycin. CONCLUSIONS Hospital effluents tested contained antibiotic-resistant bacteria, which are released into receiving water bodies, resulting in a threat to public health.
Automated Scoring Using A Hybrid Feature Identification Technique

This study exploits statistical redundancy inherent in natural language to automatically predict scores for essays. We use a hybrid feature identification method, including syntactic structure analysis, rhetorical structure analysis, and topical analysis, to score essay responses from test-takers of the Graduate Management Admissions Test (GMAT) and the Test of Written English (TWE). For each essay question, a stepwise linear regression analysis is run on a training set (sample of human scored essay responses) to extract a weighted set of predictive features for each test question. Score prediction for cross-validation sets is calculated from the set of predictive features. Exact or adjacent agreement between the Electronic Essay Rater (e-rater) score predictions and human rater scores ranged from 87% to 94% across the 15 test questions.
Energy drinks in the Gulf Cooperation Council states: A review

Energy drinks have become a popular beverage worldwide. This review was carried out to have an overview among adolescents and emerging adults in the Gulf Co-operation Council states about energy drinks consumption rates and other related issues such as starting age and patterns of energy drink consumption. The Medline and Embase databases were searched separately using different terms such as energy drinks, energy beverages, and caffeinated drinks. Data related to the rates of energy drinks use were entered in STATA for statistical analysis. Then, these data were used to conduct meta-analysis to estimate the rate of energy drink consumption. Overall, meta-analysis results showed that the estimated rates of energy drinks consumption is 46.9% (95% CIs, 33.2 −66.1; nine studies) with I-square 3.7%. Findings indicated that individuals start to consume energy drinks at approximately 16 years old, and males were found to consume energy drinks more frequently than females. Results from this review carry several recommendations for policy and enforcement, public education and research that can help policy and decision makers to achieve the goal of safer use of energy drinks.
One Versus Double Burr Holes for Treating Chronic Subdural Hematoma Meta-Analysis

Abstract: Objective and Design: There is controversy among neurosurgeons regarding whether double burr hole craniostomy (DBHC) is better than single burr hole craniostomy (SBHC) in the treatment of chronic subdural hematoma (CSH), in terms of having a lower revision rate. In order to compare the revision rates after SBHC versus DBHC, we performed a meta-analysis of the available studies in the literature. Materials and Methods: Multiple electronic health databases were searched to identify all the studies published between 1966 and December 2010 that compared SBHC and DBHC. Data were processed in Review Manager 5.0. 18. Effect sizes were expressed in pooled odds ratio (OR) estimates, and due to heterogeneity between studies we used random effect of the inverse variance weighted method to perform the meta-analysis. Results: Five observational retrospective cohort studies were identified: four published studies and one unpublished, describing the outcomes of 355 DBHC and 358 SBHC to evacuate 713 CSH in 631 patients. Meta-analysis showed that there was no significant difference in the revision rates between double burr hole craniostomy and single burr hole craniostomy when performed to evacuate CSH. Pooled odds ratio for all the studies was 0.62 (95% confidence interval 0.26 - 1.46). Conclusions: The results of this meta-analysis suggest that SBHC is as good as DBHC in evacuating chronic subdural hematoma and is not associated with a higher revision rate compared to DBHC.
The Capacity of Polyomavirus Enhancer Binding Protein 2αB (AML1/Cbfa2) To Stimulate Polyomavirus DNA Replication Is Related to Its Affinity for the Nuclear Matrix

ABSTRACT The nuclear matrix is thought to play an important role in the DNA replication of eukaryotic cells, although direct evidence for such a role is still lacking. A nuclear matrix-associated transcription factor, polyomavirus (Py) enhancer binding protein 2αB1 (PEBP2αB1) (AML1/Cbfa2), was found to stimulate Py replication through its cognate binding site. The minimal replication activation domain (RAD) was identified between amino acid (aa) 302 and aa 371 by using a fusion protein containing the GAL4 DNA binding domain (GAL4-RAD). In addition, the region showed affinity for the nuclear matrix and, on the basis of competition studies, binding activity for one or more proteins involved in the initiation of Py DNA replication. A leukemogenic chimeric protein, AML1/ETO(MTG8), which does not contain this region of PEBP2αB1/AML1, was also localized in the nuclear matrix fraction and competed for nuclear matrix association with PEBP2αB1 and GAL4-RAD. Moreover, AML1/ETO inhibited Py DNA replication stimulated by PEBP2αB1 and GAL4-RAD. The inhibition was specific for replication mediated by PEBP2αB1 and GAL4-RAD, and proportional to the degree of loss of these activators from the nuclear matrix, suggesting a requirement for nuclear matrix targeting in the stimulation of Py DNA replication by RAD. These results are the first to suggest a molecular link between the initiation of DNA replication and the nuclear matrix compartment.
A Common Left Occipito-Temporal Dysfunction in Developmental Dyslexia and Acquired Letter-By-Letter Reading?

Background We used fMRI to examine functional brain abnormalities of German-speaking dyslexics who suffer from slow effortful reading but not from a reading accuracy problem. Similar to acquired cases of letter-by-letter reading, the developmental cases exhibited an abnormal strong effect of length (i.e., number of letters) on response time for words and pseudowords. Results Corresponding to lesions of left occipito-temporal (OT) regions in acquired cases, we found a dysfunction of this region in our developmental cases who failed to exhibit responsiveness of left OT regions to the length of words and pseudowords. This abnormality in the left OT cortex was accompanied by absent responsiveness to increased sublexical reading demands in phonological inferior frontal gyrus (IFG) regions. Interestingly, there was no abnormality in the left superior temporal cortex which—corresponding to the onological deficit explanation—is considered to be the prime locus of the reading difficulties of developmental dyslexia cases. Conclusions The present functional imaging results suggest that developmental dyslexia similar to acquired letter-by-letter reading is due to a primary dysfunction of left OT regions.
Infinitesimal spectral flow and scattering matrix

In this note the notion of infinitesimal scattering matrix is introduced. It is shown that under certain assumption, the scattering operator of a pair of trace compatible operators is equal to the chronological exponential of the infinitesimal scattering matrix and that the trace of the infinitesimal scattering matrix is equal to the absolutely continuous part of the infinitesimal spectral flow. As a corollary, a variant of the Birman-Krein formula is derived. An interpretation of Pushnitski's $\mu$-invariant is given.
Integrated plasticity at inhibitory and excitatory synapses in the cerebellar circuit

The way long-term potentiation (LTP) and depression (LTD) are integrated within the different synapses of brain neuronal circuits is poorly understood. In order to progress beyond the identification of specific molecular mechanisms, a system in which multiple forms of plasticity can be correlated with large-scale neural processing is required. In this paper we take as an example the cerebellar network, in which extensive investigations have revealed LTP and LTD at several excitatory and inhibitory synapses. Cerebellar LTP and LTD occur in all three main cerebellar subcircuits (granular layer, molecular layer, deep cerebellar nuclei) and correspondingly regulate the function of their three main neurons: granule cells (GrCs), Purkinje cells (PCs) and deep cerebellar nuclear (DCN) cells. All these neurons, in addition to be excited, are reached by feed-forward and feed-back inhibitory connections, in which LTP and LTD may either operate synergistically or homeostatically in order to control information flow through the circuit. Although the investigation of individual synaptic plasticities in vitro is essential to prove their existence and mechanisms, it is insufficient to generate a coherent view of their impact on network functioning in vivo. Recent computational models and cell-specific genetic mutations in mice are shedding light on how plasticity at multiple excitatory and inhibitory synapses might regulate neuronal activities in the cerebellar circuit and contribute to learning and memory and behavioral control.
Neuroprotection by Minocycline Caused by Direct and Specific Scavenging of Peroxynitrite*

Minocycline prevents oxidative protein modifications and damage in disease models associated with inflammatory glial activation and oxidative stress. Although the drug has been assumed to act by preventing the up-regulation of proinflammatory enzymes, we probed here its direct chemical interaction with reactive oxygen species. The antibiotic did not react with superoxide or •NO radicals, but peroxynitrite (PON) was scavenged in the range of ∼1 μm minocycline and below. The interaction of pharmacologically relevant minocycline concentrations with PON was corroborated in several assay systems and significantly exceeded the efficacy of other antibiotics. Minocycline was degraded during the reaction with PON, and the resultant products lacked antioxidant properties. The antioxidant activity of minocycline extended to cellular systems, because it prevented neuronal mitochondrial DNA damage and glutathione depletion. Maintenance of neuronal viability under PON stress was shown to be solely dependent on direct chemical scavenging by minocycline. We chose α-synuclein (ASYN), known from Parkinsonian pathology as a biologically relevant target in chemical and cellular nitration reactions. Submicromolar concentrations of minocycline prevented tyrosine nitration of ASYN by PON. Mass spectrometric analysis revealed that minocycline impeded nitrations more effectively than methionine oxidations and dimerizations of ASYN, which are secondary reactions under PON stress. Thus, PON scavenging at low concentrations is a novel feature of minocycline and may help to explain its pharmacological activity.
Assessment of Wake-Tail Interference Effects on the Dynamics of Flexible Aircraft

This work investigates the effect of aerodynamic interference in the coupled nonlinear aeroelasticity and flight mechanics of flexible lightweight aircraft at low speeds. For that purpose, a geometrically exact composite-beam formulation is used to model the vehicle flexible-body dynamics by means of an intuitive and easily linearizable representation based on the displacement and Cartesian rotation vectors. The aerodynamics are modeled using the unsteady vortex-lattice method, which captures the instantaneous shape of the lifting surfaces and the free inviscid wake, including large deformations and interference effects. This results in a framework for simulation of high aspect ratio planes that provides a medium-fidelity representation of flexible-aircraft dynamics with a modest computational cost. Previous independent studies on the structural-dynamics and aerodynamics modules are complemented here with the integrated simulation methodology, including vehicle trim, and linear and nonlinear time-domain solutions. A numerical investigation is next presented on a simple wing-fuselage-tail configuration, assessing the interference effects between wing wake and horizontal tail, and the downwash due to the proximity of the wake is shown to play a significant role in the longitudinal dynamics of the vehicle. Finally, a brief discussion of direct wake-tail encounters is included to show the limitations of the approach.
Effects of Moisture Absorption and Test Method on the Properties of E-glass/Polyester Hull Laminates

Effects of moisture absorption on the tensile, compressive, shear, bending and bending fatigue properties of an iso-polyester/E-glass hull laminate were studied. Fickian diffusion constants were found that closely modeled moisture absorption. Comparisons were made of standard moisture experiments using boiling water versus long-term exposure. Results indicated that the boiling water test yielded significantly conservative values. Fatigue endurance limits were found to be near 25% of static load, indicating a fatigue design factor of four is required for infinite service with this material. Coupon results were used with finite element analysis (FEA) to predict panel deformations and strains. Good correlation was achieved.