Miracle-dz/UniFAR-FTUs huggingface dataset:
Experimental nodular goitre.

IN a previous communication (Bielschowsky, 1944a) the production of benign and malignant tumours of the thyroid gland by the simultaneous feeding of 2-acetyl-aminofluorene and allyl-thiourea has been reported. It was shown that the goitrous gland was susceptible to the action of a carcinogen which did not affect the unstimulated thyroid. I have now studied the effects produced by the successive feeding of 2-acetylamino-fluorene and allyl-thiourea on the thyroid gland of rats. The purpose of these experiments was to obtain material more amenable to analysis of the pathogenesis of the acetyl-amino-fluorene induced tumours of the thyroid, and to decide whether the simultaneous feeding of the carcinogenic and the goitrogenic substances was a requisite for the production of these neoplasms. The question of whether simultaneous feeding necessarily implied combined action, could not be answered by the previous experiment. The interpretation was made still more difficult by the presence of cancers in organs other than the thyroid. Since malignant tumours can profoundly influence enzyme systems of distant organs, a possible effect of the other acetyl-amino-fluorene induced cancers on the thyroid had to be considered. Still another possible source of error had to be excluded; it was necessary to find whether the acetyl-amino-fluorene was stored in the body of the rat after prolonged feeding. No evidence for such a storage could be obtained (Bielschowsky, 1945). While these experiments were in progress, two important papers have been published which furnish valuable information. Van Dyke (1944) described the presence of adenomata of the thyroid in very old rats, and Griesbach, Kennedy and Purves (1945) reported the production of tumours of the thyroid by prolonged feeding of a Brassica seed diet.
Using machine learning classifiers to identify glaucomatous change earlier in standard visual fields.

PURPOSE To compare the ability of several machine learning classifiers to predict development of abnormal fields at follow-up in ocular hypertensive (OHT) eyes that had normal visual fields in baseline examination. METHODS The visual fields of 114 eyes of 114 patients with OHT with four or more visual field tests with standard automated perimetry over three or more years and for whom stereophotographs were available were assessed. The mean (+/-SD) number of visual field tests was 7.89 +/- 3.04. The mean number of years covered (+/-SD) was 5.92 +/- 2.34 (range, 2.81-11.77). Fields were classified as normal or abnormal based on Statpac-like methods (Humphrey Instruments, Dublin, CA) and by several machine learning classifiers. The machine learning classifiers were two types of support vector machine (SVM), a mixture of Gaussian (MoG) classifier, a constrained MoG, and a mixture of generalized Gaussian (MGG). Specificity was set to 96% for all classifiers, using data from 94 normal eyes evaluated longitudinally. Specificity cutoffs required confirmation of abnormality. RESULTS Thirty-two percent (36/114) of the eyes converted to abnormal fields during follow-up based on the Statpac-like methods. All 36 were identified by at least one machine classifier. In nearly all cases, the machine learning classifiers predicted the confirmed abnormality, on average, 3.92 +/- 0.55 years earlier than traditional Statpac-like methods. CONCLUSIONS Machine learning classifiers can learn complex patterns and trends in data and adapt to create a decision surface without the constraints imposed by statistical classifiers. This adaptation allowed the machine learning classifiers to identify abnormality in visual field converts much earlier than the traditional methods.
TSOtool: a program for verifying memory systems using the memory consistency model

In this paper, we describe TSOtool, a program to check the behavior of the memory subsystem in a shared memory multiprocessor. TSOtool runs pseudo-randomly generated programs with data races on a system compliant with the total store order (TSO) memory consistency model; it then checks the results of the program against the formal TSO specification. Such analysis can expose subtle memory errors like data corruption, atomicity violation and illegal instruction ordering. While verifying TSO compliance completely is an NP-complete problem, we describe a new polynomial time algorithm which is incorporated in TSOtool. In spite of being incomplete, it has been successful in detecting several bugs in the design of commercial microprocessors and systems, during both pre-silicon and post-silicon phases of validation.
New Media Simulation Stories in Nursing Education: A Quasi-Experimental Study Exploring Learning Outcomes

New media simulation stories are short multimedia presentations that combine simulation, digital technology, and story branching to depict a variety of healthcare-related scenarios. The purpose of this study was to explore whether learning outcomes were enhanced if students viewed the results of both correct and incorrect nursing actions demonstrated through new media simulation stories. A convenience sample of 109 undergraduate nursing students in a family-centered maternity course participated in the study. Study findings suggests that students who viewed both correct and incorrect depictions of maternity nursing actions scored better on tests than did those students who viewed only correct nursing actions.
The Inflection-Point Retracking Algorithm: Improved Jason-2 Sea Surface Heights in the Strait of Hormuz

ABSTRACT In this study, a waveform retracking algorithm based on finding the inflection-point of the waveform is proposed. After two-steps pre-processing procedure, we employ this method for 145 cycles of Jason-2 data for two tracks 81 and 16 over the Strait of Hormuz. Moreover, we obtain the corrected SSH by the common empirical methods namely Offset Centre of Gravity, Beta and Threshold as well as the ALES. We compare the SSH time series from proposed algorithm with those from common empirical methods. Results are validated against three nearby tide-gauges in the case study. The correlation coefficient and RMSE between the corrected SSH and tide-gages data were computed for three distance classes from the coastline: 0∼5, 5∼10 and 10∼15 kilometer. Our method improves the averaged RMSE of raw SSH up to 41%, 41% and 24%, for these classes over track 81 and 51%, 38% and 41% over track 16, respectively. The averaged correlation values of the proposed method indicate 33%, 11% and 2% improvement over track 81 and are 29%, 14% and 3% over track 16 for three distance groups, respectively. Our method leads to slightly better results than the successful ALES method, especially within the range of 0∼5 km.
Recent trends reveal decreasing intensity of daily precipitation in Spain

A comprehensive analysis of the spatial and temporal variability of daily precipitation in Spain in the period 1950–2012 was carried out based on the high‐resolution gridded data set SPREAD at a 5 × 5 km spatial resolution. Temporal trends of 12 daily precipitation indices were computed by application of the Sen's slope and the Mann–Kendall tests. The spatial distribution of the trends showed (a) a global slight increase in the duration of the precipitation events, especially along the Mediterranean fringe; (b) an increase of the frequency of low precipitation events and a decrease of the frequency of high and very high events (inverse in the Mediterranean coast); and (c) a slight decrease of the intensity when considering single events (1‐ or 5‐day duration), but a significant negative trend in mean and median precipitation when considering all the precipitation days (p > 0), especially in the Mediterranean coast.
Committed Dis(s)idents: Participation in Radical Collective Action Fosters Disidentification With the Broader In-Group But Enhances Political Identification

The present research examined the hypothesis that participation in radical, but not moderate, action results in disidentification from the broader in-group. Study 1 (N = 98) was a longitudinal study conducted in the context of student protests against tuition fees in Germany and confirmed that participation in radical collective action results in disidentification with the broader in-group (students) whereas participation in moderate collective action does not. Both types of action increased politicized identification. Study 2 (N = 175) manipulated the normativeness of different types of imagined collective actions in the same context and replicated this disidentification effect for radical actions, but only when this action mismatched the broader in-group’s norms. This study also indicated that these effects were partially mediated by perceived lack of solidarity and perceived lack of commitment to the cause among the broader in-group. The implications of these findings for understanding radicalization within social movements are discussed.
Neonatal pain management: still in search of the Holy Grail

Inadequate pain management but also inappropriate use of analgesics in early infancy has negative effects on neurodevelopmental outcome. As a consequence, neonatal pain management is still in search for the Holy Grail. At best, effective pain management is based on prevention, assessment, and treatment followed by a re-assessment of the pain to determine if additional treatment is still necessary. Unfortunately, epidemiological observations suggest that neonates are undergoing painful procedures very frequently, unveiling the need for effective preventive, non-pharmacological strategies. In addition, assessment is still based on validated, multimodal, but subjective pain assessment tools. Finally, in neonatal intensive care units, there is a shift in clinical practices (e.g., shorter intubation and ventilation), and this necessitates the development and validation of new pharmacological treatment modalities. To illustrate this, a shift in the use of opioids to paracetamol has occurred and short-acting agents (remifentanil, propofol) are more commonly administered to neonates. In addition to these new modalities and as part of a more advanced approach of the developmental pharmacology of analgesics, pharmacogenetics also emerged as a tool for precision medicine in neonates. To assure further improvement of neonatal pain management the integration of pharmacogenetics with the usual covariates like weight, age and/or disease characteristics is needed.
Discordant patterns of genetic and phenotypic differentiation in five grasshopper species codistributed across a microreserve network

Conservation plans can be greatly improved when information on the evolutionary and demographic consequences of habitat fragmentation is available for several codistributed species. Here, we study spatial patterns of phenotypic and genetic variation among five grasshopper species that are codistributed across a network of microreserves but show remarkable differences in dispersal‐related morphology (body size and wing length), degree of habitat specialization and extent of fragmentation of their respective habitats in the study region. In particular, we tested the hypothesis that species with preferences for highly fragmented microhabitats show stronger genetic and phenotypic structure than codistributed generalist taxa inhabiting a continuous matrix of suitable habitat. We also hypothesized a higher resemblance of spatial patterns of genetic and phenotypic variability among species that have experienced a higher degree of habitat fragmentation due to their more similar responses to the parallel large‐scale destruction of their natural habitats. In partial agreement with our first hypothesis, we found that genetic structure, but not phenotypic differentiation, was higher in species linked to highly fragmented habitats. We did not find support for congruent patterns of phenotypic and genetic variability among any studied species, indicating that they show idiosyncratic evolutionary trajectories and distinctive demographic responses to habitat fragmentation across a common landscape. This suggests that conservation practices in networks of protected areas require detailed ecological and evolutionary information on target species to focus management efforts on those taxa that are more sensitive to the effects of habitat fragmentation.
Key Contributors to Signal Generation in Frequency Mixing Magnetic Detection (FMMD): An In Silico Study

Frequency mixing magnetic detection (FMMD) is a sensitive and selective technique to detect magnetic nanoparticles (MNPs) serving as probes for binding biological targets. Its principle relies on the nonlinear magnetic relaxation dynamics of a particle ensemble interacting with a dual frequency external magnetic field. In order to increase its sensitivity, lower its limit of detection and overall improve its applicability in biosensing, matching combinations of external field parameters and internal particle properties are being sought to advance FMMD. In this study, we systematically probe the aforementioned interaction with coupled Néel–Brownian dynamic relaxation simulations to examine how key MNP properties as well as applied field parameters affect the frequency mixing signal generation. It is found that the core size of MNPs dominates their nonlinear magnetic response, with the strongest contributions from the largest particles. The drive field amplitude dominates the shape of the field-dependent response, whereas effective anisotropy and hydrodynamic size of the particles only weakly influence the signal generation in FMMD. For tailoring the MNP properties and parameters of the setup towards optimal FMMD signal generation, our findings suggest choosing large particles of core sizes dC>25 nm with narrow size distributions (σ<0.1) to minimize the required drive field amplitude. This allows potential improvements of FMMD as a stand-alone application, as well as advances in magnetic particle imaging, hyperthermia and magnetic immunoassays.
Automatic Annotation of Seismocardiogram With High-Frequency Precordial Accelerations

Seismocardiogram (SCG) is the low-frequency vibrations signal recorded from the chest using accelerometers. Peaks on dorsoventral and sternal SCG correspond to specific cardiac events. Prior research work has shown the potential of extracting such peaks for various types of monitoring and diagnosis applications. However, annotation of these peaks is not a trivial task and complicated in some subjects. In this paper, an automated method is proposed to annotate these peaks. The high-frequency accelerations obtained from the same accelerometer, used to record SCG with, were used to facilitate the annotation of the SCG. Algorithms were developed for detection of isovolumic moment (IM) and aortic valve closure (AC) points of SCG. Four different envelope calculation methods were used: cardiac sound characteristic waveform (CSCW), Shannon, absolute, and Hilbert. The algorithms were evaluated based on a dataset including 18 subjects undergoing lower body negative pressure and were further tested with another dataset, which included 67 subjects. These datasets had been previously manually annotated. The algorithm based on CSCW envelope calculation produced the highest detection accuracy for both IM and AC. The overall CSCW algorithm detection accuracy for the test dataset was 98.7% and 99.1% for the IM and AC points, respectively.
Microfibrils at Basement Membrane Zones Interact with Perlecan via Fibrillin-1*

Mutational defects in fibrillin-rich microfibrils give rise to a number of heritable connective tissue disorders, generally termed microfibrillopathies. To understand the pathogenesis of these microfibrillopathies, it is important to elucidate the supramolecular composition of microfibrils and their interaction properties with extracellular matrix components. Here we demonstrate that the proteoglycan perlecan is an associated component of microfibrils typically close to basement membrane zones. Double immunofluorescence studies demonstrate colocalization of fibrillin-1, the major backbone component of microfibrils, with perlecan in fibroblast cultures as well as in dermal and ocular tissues. Double immunogold labeling further confirms colocalization of perlecan to microfibrils in various tissues at the ultrastructural level. Extraction studies revealed that perlecan is not covalently associated with microfibrils. High affinity interactions between fibrillin-1 and perlecan were found by kinetic binding studies with dissociation constants in the low nanomolar range. A detailed mapping study of the interaction epitopes by solid phase binding assays primarily revealed interactions of perlecan domains I and II with a central region of fibrillin-1. Analysis of perlecan null embryos showed less microfibrils at the dermal-epidermal junction as compared with wild-type littermates. The data presented indicate a functional significance for perlecan in anchoring microfibrils to basement membranes and in the biogenesis of microfibrils.
Demonstration of subthrehold swing smaller than 60mV/decade in Fe-FET with P(VDF-TrFE)/SiO2 gate stack

This work experimentally demonstrates, for the first time, that by integrating a thin ferroelectric layer into a gate stack of a standard MOS transistor one, it is possible to overcome the 60 mV/decade subthreshold swing limit at room temperature of MOSFET. We find sub-threshold swings as low as 13 mV/decade in Fe-FETs with 40 nm P(VDF-TrFE)/SiO2 gate stack. The mechanism governing the low subthreshold swing in Fe-FET transistors is the negative capacitance of the ferroelectric layer that provides voltage amplification; with our particular ferroelectric gate stack we report for the first time negative capacitance at room temperature.
Differential involvement of the senses in disgust memories

One prediction derived from the disease avoidance account of disgust is that proximal disgust cues (smells, tastes and touches) should elicit this emotion more intensely than distal disgust cues (sights and sounds). If correct, then memories of disgusting experiences should involve smelling, tasting or touching to a greater degree than seeing or hearing. Two surveys were conducted on university students to test this idea, drawing upon their naturalistic experiences. Survey 1 (N = 127) asked participants to detail their most memorable disgusting, fear-provoking, morally repulsive and yucky/gross experience, with each recollection self-rated for sensory involvement. Survey 2 (N = 89) employed the same task, but this time, participants recollected their most common disgusting, fear-provoking, morally repulsive and yucky/gross experience in the preceding week. The majority of disgusting experiences were core disgusts—i.e. related to disease/pathogen presence or stimuli. The proximal and distal sensory cues contributed equally to individuals’ most memorable core disgust experiences, but the proximal senses were more involved than the distal senses in individuals’ most common core disgust experiences. Further, the proximal sensory cues, as compared with the distal sensory cues, were signficantly more involved in core disgust experiences than in morally repulsive and fear-provoking experiences. The implications of these findings for a disease avoidance account of disgust, for multi-sensory disgust research, and core disgust’s classification as an emotion or a drive, are discussed.
Prevalence of Styloid Process Elongation on Panoramic Radiography in the Turkey Population from Cappadocia Region

Objectives The aim of this study is to determine the prevalence of styloid process elongation (SPE) detected on panoramic radiographs (PRs) in Cappadocia region population in Turkey and to investigate the SPE incidences in relation to the age subgroups. Methods Between 2004 to 2007 years, a random sample of 750 PRs was collected from the data files and any questionable PR was excluded. Therefore, 698 PRs were included in the present study. The subjects were divided into six age subgroups: 10–19, 20–29, 30–39, 40–49, 50–59 and 60 years and older. Fifty-four (7.7%) patients demonstrated SPE at least one side. Results There were statistical differences between 10–19, 20–29 age subgroups and 30–39, 50–59 age subgroups in terms of the SPE prevalence, but not other subgroups. Conclusions According to our knowledge, this is the highest prevalence in comparison to the other Turkish reports and the first study in terms of the SPE prevalence in Cappadocia region population. Also, the subgroup analyse suggested that the age may not have a role in the elongation of the SP.
The caries-reducing benefit of fluoride-release from dental restorative materials continues after fluoride-release has ended

Abstract Objective. This study tested the hypothesis that the benefit of fluoride-releasing restorative materials continues even after their reserve of fluoride has been depleted. Materials and methods. Pits in perspex blocks simulating cavities were filled with either a fluoride-releasing or a non-fluoride-releasing restorative material and a dentin single-section was placed 1 mm from the edge of the filled pit. These combinations were exposed to an acid gel system. Each demineralized dentin section was separated from the adjacent material and immersed in fresh demineralizing solutions. Transversal microradiographs were taken following the two experimental periods. This study defined ΔΔZ as the increase of integrated mineral loss (ΔZ) during the second acid attack. Results. The first acid attack substantially demineralized the near-surface region (depth < 40 μm) in all samples. The second acid attack, however, did not cause further demineralization in this near-surface region. Instead, it demineralized dentin deeper than 40–60 μm. The ΔΔZ of the material that did not release fluoride was significantly greater than that of fluoride-releasing materials. Negative correlations were found between ΔΔZ and the mineral volume% of the near-surface region and lesion body of the initial lesions. These results indicate that the dentin mineral in the near-surface region is chemically altered to become acid-resistant fluorapatite. In addition, lesion progression during the second period of demineralization, which was fluoride-free, may have been affected for the materials that have high mineral content of the surface layer and lesion body. Conclusions. It is concluded that dentin surrounding fluoride-releasing materials is protected against demineralization even after the fluoride release has diminished.