Miracle-dz/UniFAR-FTUs huggingface dataset:
Physical Activity and Health Outcomes Three Months After Completing a Physical Activity Behavior Change Intervention: Persistent and Delayed Effects

Purpose: We previously reported the effectiveness of a 12-week physical activity behavior change intervention for breast cancer survivors postintervention with this report, aiming to determine delayed and/or persistent effects 3 months after intervention completion. Methods: Forty-one sedentary women with stage I, II, or IIIA breast cancer currently receiving hormonal therapy were randomly assigned to receive the 12-week Better Exercise Adherence after Treatment for Cancer intervention or usual care. Assessments occurred at baseline, postintervention, and 3 months postintervention. Results: Weekly minutes of greater than or equal to moderate intensity physical activity measured by accelerometer showed a significant group by time interaction (F = 3.51; P = 0.035; between group difference in the mean change from baseline to 3 months postintervention, 100.1 minute, P = 0.012). Significant group by time interactions also showed sustained improvements from baseline to 3 months postintervention in strength (F = 3.82; P = 0.027; between group difference, 11.2 kg; P = 0.026), waist-to-hip ratio (F = 3.36; P = 0.041; between group difference, −0.04; P = 0.094), and social well-being (F = 4.22; P = 0.023; between group difference, 3.9; P = 0.039). A delayed reduction in lower extremity dysfunction 3 months postintervention was noted (F = 3.24; P = 0.045; between group difference in the mean change from postintervention to 3 months follow-up; P = −7.6; P = 0.015). No group by time effect was noted for fitness, body mass index, percent fat, bone density, total quality of life (Functional Assessment of Cancer Therapy-General), fatigue, endocrine symptoms, cognitive function, or sleep. Conclusions: The intervention resulted in sustained improvements in physical activity, strength, central adiposity, and social well-being with lower extremity function benefits appearing 3 months after intervention completion. Testing translation in a multisite study is warranted. (Cancer Epidemiol Biomarkers Prev 2009;18(5):1410–8)
Disruption of Spermatogenic Cell Adhesion and Male Infertility in Mice Lacking TSLC1/IGSF4, an Immunoglobulin Superfamily Cell Adhesion Molecule

ABSTRACT TSLC1/IGSF4, an immunoglobulin superfamily molecule, is predominantly expressed in the brain, lungs, and testes and plays important roles in epithelial cell adhesion, cancer invasion, and synapse formation. We generated Tslc1/Igsf4-deficient mice by disrupting exon 1 of the gene and found that Tslc1−/− mice were born with the expected Mendelian ratio but that Tslc1−/− male mice were infertile. In 11-week-old adult Tslc1−/− mice, the weight of a testis was 88% that in Tslc1+/+ mice, and the number of sperm in the semen was approximately 0.01% that in Tslc1+/+ mice. Histological analysis revealed that the round spermatids and the pachytene spermatocytes failed to attach to the Sertoli cells in the seminiferous tubules and sloughed off into the lumen with apoptosis in the Tslc1−/− mice. On the other hand, the spermatogonia and the interstitial cells, including Leydig cells, were essentially unaffected. In the Tslc1+/+ mice, TSLC1/IGSF4 expression was observed in the spermatogenic cells from the intermediate spermatogonia to the early pachytene spermatocytes and from spermatids at step 7 or later. These findings suggest that TSLC1/IGSF4 expression is indispensable for the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.
Gastric Antimicrobial Peptides Fail to Eradicate Helicobacter pylori Infection Due to Selective Induction and Resistance

Background Although antimicrobial peptides protect mucus and mucosa from bacteria, Helicobacter pylori is able to colonize the gastric mucus. To clarify in which extend Helicobacter escapes the antimicrobial defense, we systematically assessed susceptibility and expression levels of different antimicrobial host factors in gastric mucosa with and without H. pylori infection. Materials and Methods We investigated the expression levels of HBD1 (gene name DEFB1), HBD2 (DEFB4A), HBD3 (DEFB103A), HBD4 (DEFB104A), LL37 (CAMP) and elafin (PI3) by real time PCR in gastric biopsy samples in a total of 20 controls versus 12 patients colonized with H. pylori. Immunostaining was performed for HBD2 and HBD3. We assessed antimicrobial susceptibility by flow cytometry, growth on blood agar, radial diffusion assay and electron microscopy. Results H. pylori infection was associated with increased gastric levels of the inducible defensin HBD2 and of the antiprotease elafin, whereas the expression levels of the constitutive defensin HBD1, inducible HBD3 and LL37 remained unchanged. HBD4 was not expressed in significant levels in gastric mucosa. H. pylori strains were resistant to the defensins HBD1 as well as to elafin, and strain specific minimally susceptible to HBD2, whereas HBD3 and LL37 killed all H. pylori strains effectively. We demonstrated the binding of HBD2 and LL37 on the surface of H. pylori cells. Comparing the antibacterial activity of extracts from H. pylori negative and positive biopsies, we found only a minimal killing against H. pylori that was not increased by the induction of HBD2 in H. pylori positive samples. Conclusion These data support the hypothesis that gastric H. pylori evades the host defense shield to allow colonization.
The Influence of Societal Culture on the Adoption of Information Systems: The Case of Libya

This study is part of a larger study that explores societal and organizational culture factors that influence the adoption of information systems (IS) in Libya’s Oil and Banking sectors (Twati & Gammack, 2004; 2006). Using a structured survey questionnaire based on the work of Geert Hofstede’s Value Survey Module (VSM 94), 400 questionnaires were administrated to middle and top management employees in more than 15 government and public organizations in the two named industry sectors. The findings showed that there is a direct positive relationship between Hofstede’s (1980) societal culture dimensions and the adoption of IS. The findings also showed that there are no differences in the societal culture dimensions between the two sectors covered in this study. This implies that the adoption of IS is influenced by societal culture and other factors, which are worthy of investigating. The future implications of this research are also discussed. BACKGROUND
Measurements and implications of the relationship between lightning and terrestrial gamma ray flashes

We report observations and analysis of 30 kHz radio emissions (sferics) from lightning discharges associated with 26 terrestrial gamma ray flashes (TGFs) recorded by the RHESSI satellite over the Caribbean and Americas, between 1500 and 4000 km away from the magnetic field sensors located at Duke University. Thirteen of the TGFs are found to occur within −3/+1 ms of lightning discharges of positive polarity from the direction of the RHESSI subsatellite point, strongly indicating that the TGFs are linked to these discharges. The event timing and sferic direction finding reveals that the discharges occur within a ∼300 km radius circle around the RHESSI subsatellite point. Although the positive polarity of all 13 discharges is consistent with runaway breakdown, the lightning charge moment changes are approximately two orders of magnitude smaller than present high altitude runaway breakdown theory predicts. Implications of these measurements are discussed.
The Secrets of Storytelling : Why We Love a Good Yarn

When Brad Pitt tells Eric Bana in the 2004 film Troy that “there are no pacts between lions and men,” he is not reciting a clever line from the pen of a Hollywood screenwriter. He is speaking Achillesʼ words in English as Homer wrote them in Greek more than 2,000 years ago in the Iliad. The tale of the Trojan War has captivated generations of audiences while evolving from its origins as an oral epic to written versions and, finally, to several film adaptations. The power of this story to transcend time, language and culture is clear even today, evidenced by Troyʼs robust success around the world.
Outcome of Extracorporeal Shock Wave Therapy for Insertional Achilles Tendinopathy with and without Haglund's Deformity

Purpose. To compare the results of extracorporeal shock wave therapy (ESWT) for insertional Achilles tendinopathy (IAT) with or without Haglund's deformity. Methods. Between September 2014 and May 2015, all patients who underwent ESWT were retrospectively enrolled in this study. A total of 67 patients were available for follow-up and assigned into nondeformtiy group (n = 37) and deformtiy group (n = 30). Clinical outcomes were evaluated by VISA-A Score and 6-point Likert scale. Results. The VISA-A score increased in both groups, from 49.57 ± 9.98 at baseline to 83.86 ± 8.59 at 14.5 ± 7.2 months after treatment in nondeformity group (P < 0.001) and from 48.70 ± 9.38 at baseline to 67.78 ± 11.35 at 15.3 ± 6.7 months after treatment in deformity group (P < 0.001). However, there was a greater improvement in VISA-A Score for the nondeformity group compared with deformity group (P = 0.005). For the 6-point Likert scale, there were decreases from 3.92 ± 0.80 at baseline to 1.57 ± 0.73 at the follow-up time point in nondeformity group (P < 0.001) and from 4.0 ± 0.76 at baseline to 2.37 ± 1.03 at the follow-up time point in deformity group (P < 0.001). There was no significant difference in improvement of the 6-point Likert scale between both groups (P = 0.062). Conclusions. ESWT resulted in greater clinical outcomes in patients without Haglund's deformity compared with patients with Haglund's deformity.
‘I am Italian in the world’: a mobile student’s story of language learning and ideological becoming

ABSTRACT This article theorises the relationship between language and intercultural learning from a Bakhtinian dialogic perspective, based on the language learning story of Federica, a mobile student in UK higher education (HE). I first outline the context of UK HE and its internationalisation agenda, discussing how research in this field has conceptualised language, intercultural communication (IC) and international students in terms of a totalising boundary between self and other. I link this to current concerns in IC regarding the philosophical underpinnings of the field, specifically the aporia created as a result of the totalising self/other relation in prevailing IC discourse. I then present a means of addressing this aporia through a Bakhtinian theorisation of the relationship between language and intercultural learning. This theorisation offers a relational perspective on the self and the other in which intercultural learning is a process of ideological becoming with the other, enacted in, with and through language, as illustrated in Federica’s story of learning English. The article concludes with a call for language and communicative practices to be placed at the heart of HE internationalisation agendas and for HE practitioners to recognise shared responsibility for IC.
The rise and fall of industrial clusters: Technology and the life cycle of region

When a major technological innovation spreads out in both high-tech and middle/low-tech industries, new clusters appear, develop and grow at the expenses of "older" historical industrial sites. The literature has, under various labels, recognised three main stages of cluster development: an initial stage sparked by an initial exogenous, shock; a second stage driven by Marshall's (1920) agglomeration economies (labour market pooling, supply of intermediate goods and services and knowledge spillovers); a third stage in which the cluster either achieves a sectoral leadership or declines. The paper shows how different clusters' evolution (often told as separated stories) are part of a wider picture in which technological and spatial interactions between emerging and declining clusters play a decisive role. A final section draws some policy suggestions for public authorities and regional planners dealing with the development of an innovative cluster.
HCMV triggers frequent and persistent UL40-specific unconventional HLA-E-restricted CD8 T-cell responses with potential autologous and allogeneic peptide recognition

Immune response against human cytomegalovirus (HCMV) includes a set of persistent cytotoxic NK and CD8 T cells devoted to eliminate infected cells and to prevent reactivation. CD8 T cells against HCMV antigens (pp65, IE1) presented by HLA class-I molecules are well characterized and they associate with efficient virus control. HLA-E-restricted CD8 T cells targeting HCMV UL40 signal peptides (HLA-EUL40) have recently emerged as a non-conventional T-cell response also observed in some hosts. The occurrence, specificity and features of HLA-EUL40 CD8 T-cell responses remain mostly unknown. Here, we detected and quantified these responses in blood samples from healthy blood donors (n = 25) and kidney transplant recipients (n = 121) and we investigated the biological determinants involved in their occurrence. Longitudinal and phenotype ex vivo analyses were performed in comparison to HLA-A*02/pp65-specific CD8 T cells. Using a set of 11 HLA-E/UL40 peptide tetramers we demonstrated the presence of HLA-EUL40 CD8 αβT cells in up to 32% of seropositive HCMV+ hosts that may represent up to 38% of total circulating CD8 T-cells at a time point suggesting a strong expansion post-infection. Host’s HLA-A*02 allele, HLA-E *01:01/*01:03 genotype and sequence of the UL40 peptide from the infecting strain are major factors affecting the incidence of HLA-EUL40 CD8 T cells. These cells are effector memory CD8 (CD45RAhighROlow, CCR7-, CD27-, CD28-) characterized by a low level of PD-1 expression. HLA-EUL40 responses appear early post-infection and display a broad, unbiased, Vβ repertoire. Although induced in HCMV strain-dependent, UL4015-23-specific manner, HLA-EUL40 CD8 T cells are reactive toward a broader set of nonapeptides varying in 1–3 residues including most HLA-I signal peptides. Thus, HCMV induces strong and life-long lasting HLA-EUL40 CD8 T cells with potential allogeneic or/and autologous reactivity that take place selectively in at least a third of infections according to virus strain and host HLA concordance.
Separating biological and physical changes in dissolved oxygen concentration in a coral reef

Measured changes in dissolved oxygen (DO) concentrations in a coral reef at Miyako Island are markedly different from the diurnal sinusoidal pattern expected if biological processes are dominant. We were able to resolve this paradox by constructing a simple model that combines the influences of organic production and air-sea exchange with water flow and mixing through the reef system. The model successfully replicates the observed DO behavior, suggesting that the simple flow system we propose adequately accounts for these water advection effects. Our optimized estimates of gross production and respiration on the reef flat are 13 m and 5.2 g C m -2 d -1 ,giving a P:R ratio of 2.5. We obtained best fits to the data in the lagoon with a production rate of 4.9 g C m -2 d -1 and a respiration rate of 5.2 g C m -2 d -l for a P :R ratio of 0.9.
Landscape Composition and Spatial Prediction of Alveolar Echinococcosis in Southern Ningxia, China

Background Alveolar echinococcosis (AE) presents a serious public health challenge within China. Mass screening ultrasound surveys can detect pre-symptomatic AE, but targeting areas identified from hospital records is inefficient regarding AE. Prediction of undetected or emerging hotspots would increase detection rates. Voles and lemmings of the subfamily Arvicolinae are important intermediate hosts in sylvatic transmission systems. Their populations reach high densities in productive grasslands where food and cover are abundant. Habitat availability is thought to affect arvicoline population dynamic patterns and definitive host–intermediate host interactions. Arvicoline habitat correlates with AE prevalence in Western Europe and southern Gansu Province, China. Methods and Findings Xiji County, Ningxia Hui Autonomous Region, borders southern Gansu. The aims of this study were to map AE prevalence across Xiji and test arvicoline habitat as a predictor. Land cover was mapped using remotely sensed (Landsat) imagery. Infection status of 3,205 individuals screened in 2002–2003 was related, using generalised additive mixed models, to covariates: gender; farming; ethnicity; dog ownership; water source; and areal cover of mountain pasture and lowland pasture. A Markov random field modelled additional spatial variation and uncertainty. Mountain pasture and lowland pasture were associated with below and above average AE prevalence, respectively. Conclusions Low values of the normalised difference vegetation index indicated sub-optimality of lowland pasture for grassland arvicolines. Unlike other known endemic areas, grassland arvicolines probably did not provide the principal reservoir for Echinococcus multilocularis in Xiji. This result is consistent with recent small mammal surveys reporting low arvicoline densities and high densities of hamsters, pikas and jerboas, all suitable intermediate hosts for E. multilocularis, in reforested lowland pasture. The risk of re-emergence is discussed. We recommend extending monitoring to: southern Haiyuan County, where predicted prevalence was high; southern Xiji County, where prediction uncertainty was high; and monitoring small mammal community dynamics and the infection status of dogs.
Investigation of the multiplet features of SrTiO3 in X-ray absorption spectra based on configuration interaction calculations.

Synchrotron-based L2,3-edge absorption spectra show strong sensitivities to the local electronic structure and chemical environment. However, detailed physical information cannot be extracted easily without computational aids. Here, using the experimental Ti L2,3-edges absorption spectrum of SrTiO3 as a fingerprint and considering full multiplet effects, calculations yield different energy parameters characterizing local ground state properties. The peak splitting and intensity ratios of the L3 and L2 set of peaks are carefully analyzed quantitatively, giving rise to a small hybridization energy around 1.2 eV, and the different hybridization energy values reported in the literature are further addressed. Finally, absorption spectra with different linearly polarized photons under various tetragonal crystal fields are investigated, revealing a non-linear orbital-lattice interaction, and a theoretical guidance for material engineering of SrTiO3-based thin films and heterostructures is offered. Detailed analysis of spectrum shifts with different tetragonal crystal fields suggests that the eg crystal field splitting is a necessary parameter for a thorough analysis of the spectra, even though it is not relevant for the ground state properties.
Nitric Oxide Activates Telomerase and Delays Endothelial Cell Senescence

Endothelial cells (ECs) undergo a limited number of cell divisions, ultimately stop dividing, and enter a state that is designated replicative senescence. Shortening of telomeres is believed to be a molecular clock that triggers senescence. Telomerase, a RNA-directed DNA polymerase, extends telomeres of eukaryotic chromosomes and delays the development of senescence. In this study, we examined telomere length and the activity of telomerase during aging of human ECs in culture and elucidated the effect of nitric oxide (NO). A significant increase in senescent cells as detected by acidic &bgr;-galactosidase expression and a reduction of telomere length were found after 11 passages. Telomerase activity was reduced after the seventh passage, thereby preceding the development of EC senescence. The repeated addition of the NO donor S-nitroso-penicillamine significantly reduced EC senescence and delayed age-dependent inhibition of telomerase activity, whereas inhibition of endogenous NO synthesis had an adverse effect. Taken together, our results demonstrate that telomerase inactivation precedes EC aging. NO prevents age-related downregulation of telomerase activity and delays EC senescence.
The Risks of Coverage-Directed Test Case Generation

A number of structural coverage criteria have been proposed to measure the adequacy of testing efforts. In the avionics and other critical systems domains, test suites satisfying structural coverage criteria are mandated by standards. With the advent of powerful automated test generation tools, it is tempting to simply generate test inputs to satisfy these structural coverage criteria. However, while techniques to produce coverage-providing tests are well established, the effectiveness of such approaches in terms of fault detection ability has not been adequately studied. In this work, we evaluate the effectiveness of test suites generated to satisfy four coverage criteria through counterexample-based test generation and a random generation approach-where tests are randomly generated until coverage is achieved-contrasted against purely random test suites of equal size. Our results yield three key conclusions. First, coverage criteria satisfaction alone can be a poor indication of fault finding effectiveness, with inconsistent results between the seven case examples (and random test suites of equal size often providing similar-or even higher-levels of fault finding). Second, the use of structural coverage as a supplement-rather than a target-for test generation can have a positive impact, with random test suites reduced to a coverage-providing subset detecting up to 13.5 percent more faults than test suites generated specifically to achieve coverage. Finally, Observable MC/DC, a criterion designed to account for program structure and the selection of the test oracle, can-in part-address the failings of traditional structural coverage criteria, allowing for the generation of test suites achieving higher levels of fault detection than random test suites of equal size. These observations point to risks inherent in the increase in test automation in critical systems, and the need for more research in how coverage criteria, test generation approaches, the test oracle used, and system structure jointly influence test effectiveness.
Duration of epenthetic [t] in polysyllabic American English words

This paper reports how stress and the position of the /ns/ cluster in polysyllabic words affect [t] epenthesis in four different environments: (1) word-medial after a stressed vowel (e.g. 'cen.sus vs. 'dents us); (2) word-final after a stressed vowel (e.g. in.'tense vs. in'tents); (3) word-medial after a stressless vowel (e.g. con.'sent vs. blunt 'say.ing); and (4) word-final after a stressless vowel (e.g. 'sci.ence vs. 'con.tents). Analysis of stop closure durations in experimental sentences read by seven American English speakers reveals that position, not stress, is the most important factor in [t] epenthesis: final position (e.g. science and intense) favors epenthesis. Stress is found to have an effect on stop closure durations in the way it interacted with word-position – i.e. for the final /ns/ cluster, stress immediately before it disfavors epenthesis (e.g. intense). The underlying /t/ is shown to be not significantly longer than the epenthetic [t]. Measurements from polysyllabic words in the TIMIT corpus corroborate the experimental results that word-final position favors epenthesis and that stress does not correlate with epenthesis. In the TIMIT data, however, underlying /t/ was significantly longer than epenthetic [t].