Miracle-dz/UniFAR-FTUs huggingface dataset:
Therapy with unlabeled and 131I-labeled pan-B-cell monoclonal antibodies in nude mice bearing Raji Burkitt's lymphoma xenografts.

Clinical trials of radioimmunotherapy (RIT) of lymphoma have produced frequent tumor regressions and remissions, but it has been difficult to determine to what extent these tumor responses have been due to antibody-specific targeted radiation, nontargeted radiation, and/or cytotoxicity mediated by the carrier monoclonal antibody (MoAb). In this report, RIT was studied in athymic nude mice bearing s.c. Raji human Burkitt's lymphoma xenografts using two different pan-B-cell MoAbs, MB-1 (anti-CD37) and anti-B1 (anti-CD20), which differ in isotype (and thus the potential for interaction with host effector mechanisms) and isotype-matched control antibodies either in the unlabeled state or labeled with 131I. When a single i.p. injection of 300 microCi 131I-labeled MB-1 (IgG1) was compared to treatment with unlabeled MB-1 or 300 microCi 131I-labeled MYS control IgG1 MoAb, an antibody-specific targeted radiation effect of RIT was seen. 131I-labeled MB-1 produced a 44 +/- 19% (SEM) reduction in tumor size at 3 weeks posttreatment, while unlabeled MB-1 or 300 microCi 131I-labeled MYS control IgG1 antibody treatment resulted in continued tumor growth over this period of time. In vitro studies demonstrated that MB-1 was incapable of mediating antibody-dependent cellular cytotoxicity using Raji tumor cell targets and human peripheral blood mononuclear cells. Similar to the MB-1 studies, treatment with 300 microCi 131I-labeled anti-B1 produced a 64% reduction in mean tumor size, while 300 microCi of control antibody resulted in a 58% increase in tumor size over the same 3-week period. In contrast to MB-1, however, unlabeled anti-B1 (an IgG2a MoAb which in vitro studies showed to be capable of antibody-dependent cellular cytotoxicity) also had a substantial antitumor effect. Indeed, 300 microCi 131I-labeled anti-B1 and unlabeled anti-B1 treatment (using an equivalent amount of total protein in the treatment dose) produced a similar specific reduction in tumor size. Increasing the radionuclide dose of anti-B1 to 450 microCi in another experiment did not produce a significant difference in tumor regression compared to a 300-microCi dose. These results suggest that the antitumor effects of 131I-labeled anti-B1 treatment were dominated by antibody-mediated cytotoxicity mechanisms, such that an antibody-specific targeted radiation effect could not be distinguished. In contrast, antibody-specific targeting of radiation was the dominant mechanism of tumor killing with 131I-labeled MB-1. (ABSTRACT TRUNCATED AT 400 WORDS)
A survey of self-management in dynamic software architecture specifications

As dynamic software architecture use becomes more widespread, a variety of formal specification languages have been developed to gain a better understanding of the foundations of this type of software evolutionary change. In this paper we survey 14 formal specification approaches based on graphs, process algebras, logic, and other formalisms. Our survey will evaluate the ability of each approach to specify self-managing systems as well as the ability to address issues regarding expressiveness and scalability. Based on the results of our survey we will provide recommendations on future directions for improving the specification of dynamic software architectures, specifically self-managed architectures.
New insights into the Glass Structure and Melt Dynamics of Ge-As-Se Alloys: Topological Phases, Eutectic Effects, Slow Homogenization of Melts and Nanoscale Phase Separation Effects

The kinetics of homogenization of binary melts in the As concentration range x ∈ (0%,50%) are followed using punctuated, off-line Raman profiling, and show that 2 gm sized melts in the range x ∈ (20%,30%) take nearly two weeks to homogenize when the starting materials are reacted at 700oC. The resulting research-grade Arsenic-Selenide glasses are the most compositionally homogeneous glasses produced thus far. The enthalpy of relaxation at Tg (glass transition temperature) – ΔHnr(x) – shows a minimum in x ∈ (29%,37%) in aged samples. In such homogeneous glasses, molar volumes vary non-monotonically with composition and the fragility index m displays a broad global minimum in x ∈ (20%,40%) where m < 20. The super-strong nature of melt compositions in x ∈ (20%,40%) hinders melt diffusion at high temperatures, leading to the observed slow kinetics of melt homogenization. In comparing these results with earlier reports, there is evidence that fragility decreases as melts are homogenized. Furthermore, a clear scaling of m vs. Tg is observed with a negative slope for Flexible glasses and a positive slope for Rigid and Stressed-rigid glasses, in contrast to expectations from some popular viscosity models. The Raman spectra of a large collection of As-Se glasses were analyzed and comparisons were made with the compositional profiles of the Raman modes of the P-Se alloy. For the first time, several key similarities between the systems are observed. The quasi-tetrahedral unit with a 4-fold coordinated Arsenic atom and the As-As homopolar ethylene-like unit are detected and compositional trends are observed to be similar to those of the P-Se system. As-As homopolar bond formation occurs at much lower than the chemical threshold of the system. The impact of the eutectic at As20Se80 on the physical properties of the As-Se glasses are studied in great detail and a survey of other binary chalcogenide glasses is conducted and it is found that the eutectic region likely induces phase segregation of the compositions in the vicinity, leading to the smearing of compositional trends. The absence of the eutectic sharpens the observed topological phase boundaries. The Ge-As-Se ternary system in found to be significantly more influenced by the As atom than the Ge atom even in Ge-rich ternaries. Calorimetric and Raman spectroscopic studies reveal that the As atoms are likely both 3and 4-fold coordinated and thus have a stronger influence on the network than the Germanium atoms, thus providing further evidence to support the existence of both the quasi-tetrahedral and Ethylene-like units. 119mSn Mössbauer spectroscopic studies reveal that at least in the Ge-rich ternary Ge-Ge homopolar bonds form near the computed chemical threshold.
Preventive Effect of Tephrosia purpurea on Selenite-Induced Experimental Cataract

ABSTRACT Purpose: Recent investigations have shown that phytochemical antioxidants can scavenge free radicals and prevent various diseases like cataract. The objective of the present study was to assess the efficacy of the Tephrosia purpurea in preventing these changes in the lens of selenite-induced cataract models. Materials and methods: Cataract was induced by a single injection of sodium selenite (4 mg/kg, s.c.) to 9-day-old Sprague–Dawley rat pups. The treatment with different extracts of T. purpurea was started on 10th day and continued for 30 days in pups pretreated with sodium selenite. The animals were treated orally with either quercetin (1 mg/kg), flavonoid rich fraction (40 mg/kg) or alcohol extract (300 mg/kg) of T. purpurea. Cataract was visualized after 30 days. Encapsulated lenses were analyzed for reduced glutathione and malondialdehyde. Lenses were also analyzed for total protein, insoluble protein, total nitrite, calcium levels, protein sulfhydryl content as well as for the activities of superoxide dismutase and Ca2+-ATPase. Results: Morphological examination of the rat lenses revealed normal transparent lens with minimal or partial nuclear opacity in control whereas dense opacity developed in rat lens treated with selenite. Both the extracts of T. purpurea produced reduction in nuclear opacity as well as improvement in the insoluble proteins, protein sulfhydryl, total nitrite, calcium levels and Ca2+-ATPase activity in lenses. The extracts decreased malondialdehyde levels but also prevented the loss of reduced glutathione levels. Conclusion: Our data suggests therapeutic potential of T. purpurea for the treatment of cataract.
HHV‐6‐related secondary graft failure following allogeneic bone marrow transplantation

We report the case of an 11‐year‐old boy who underwent allogeneic bone marrow transplantation (BMT) for relapsed acute lymphoblastic leukaemia. Despite adequate engraftment, on day 45 he developed marrow aplasia with haemophagocytosis. HHV‐6 was detected in blood and bone marrow by nested PCR. Retrospective testing showed that viraemia had started on day 24. Following therapy with foscarnet and ganciclovir, viral load declined to undetectable levels and his donor marrow recovered contemporaneously. This case suggests that HHV‐6 may be a treatable cause of graft failure following BMT and provides clinical and virological evidence for the anti‐HHV‐6 activity of ganciclovir and foscarnet.
Altitudinal Variation In Phase Response Curves For The Himalayan Strains Of Drosophila Helvetica

In previous research, it was determined that the altitude of origin altered the parameters of photic entrainment and free‐running rhythmicity of adult locomotor activity of the high‐altitude Himalayan (haH) strain (Hemkund‐Sahib, 4121 m above sea level) of Drosophila helvetica compared to the low‐altitude Himalayan (laH) strain (Birahi, 1132 m above sea level) of the same species. The present study investigated whether the altitude of origin also affects the parameters of the light pulse phase response curve (PRC) of the adult locomotor activity rhythm of the haH strain. Light pulse PRCs were determined for both strains against the background of constant darkness. Although both were “weak” or type 1 PRCs, the PRC for the haH strain differed from that of the laH strain in three basic parameters. The PRC for the haH strain was of low amplitude, had a protracted dead zone, and showed a ratio of the advance to delay region (A/D>1), while the PRC of the laH strain was characterized by high amplitude, absence of dead zone, and a A/D ratio<1. The asymmetric PRCs of these strains might explain the process of photic entrainment to 24 h light‐dark cycles, as the long period of the free‐running rhythm (τ) of the haH strain is complemented with a larger advance portion of its PRC (A/D>1), whereas the short τ of the laH strain is matched with a larger delay portion of its PRC (A/D<1). Prolonged dead zone and low amplitude in the PRC of the haH strain imply that the photic sensitivity of this strain has been drastically diminished as an adaptation to environmental conditions at the altitude of its origin. While adults of this strain begin activity in very bright light in the forenoon due to non‐permissible low temperature in the morning, the converse is true for the laH strain.
Spectral properties of V4 neurons in the macaque

Spectral properties of 129 cells in the V4 area of 5 macaque monkeys were studied quantitatively with narrow-band and broad-band colored lights. The large majority of cells exhibited some degree of wavelength sensitivity within their receptive fields. The half-bandwidth of the primary peak in the spectral-response curve was less than 50 nm for 72% of the cells; the mean half-bandwidth of these cells, 27 nm, is similar to that found for color-opponent ganglion cells and cells in the parvocellular dorsal lateral geniculate nucleus (dLGN). Contrast- response functions indicated that the narrow spectral tuning of these cells derived from cone opponent interactions. From comparison of receptive-field sizes, we suggest that a typical V4 neuron sums inputs that ultimately derive from several thousand ganglion or parvocellular dLGN cells. In spite of their wavelength sensitivity, most V4 cells had properties that would not fit some simple criteria for classification as “color selective. ” First, few cells showed overt signs of color opponency, namely, on-inhibition or off-excitation to spectrally opponent wavelengths. Second, about 30% of the cells in V4 had spectral- response curves with 2 peaks. (The wavelength distribution of these second peaks was almost identical to that of primary peaks, and combinations of peak wavelengths were fairly random.) Third, most cells responded to white light; overall, the response to white light was about 60% of that to the best narrow-band or broad-band colored light. Similarly, most V4 cells gave at least a small response to all or nearly all of the different broad-band colored lights we presented. Therefore, a given V4 cell is very likely to respond to most of the colored or white surfaces in natural scenes. These combinations of response properties probably explain the widely divergent percentages of “color” cells reported in previous studies of V4. The most unusual spectral property we found in V4 was a large, spectrally sensitive surround outside the “classical receptive field” of most cells. Although stimulation of the surround by itself did not cause any response, surround stimulation could completely suppress the response to even the optimally colored stimulus in the receptive field. In general, the optimal wavelengths for receptive-field excitation and surround suppression were the same or nearly so. Thus, “color contrast” may be computed in V4. In some cases, contrasting wavelengths in the surround caused moderate enhancement of response to a receptive-field stimulus. (ABSTRACT TRUNCATED AT 400 WORDS)
(Sub)millimetre interferometric imaging of a sample of COSMOS/AzTEC submillimetre galaxies - II. The spatial extent of the radio-emitting regions

Radio emission at centimetre wavelengths from highly star-forming galaxies, like submillimetre galaxies (SMGs), is dominated by synchrotron radiation arising from supernova activity. Hence, radio continuum imaging has the potential to determine the spatial extent of star formation in these types of galaxies. Using deep, high-resolution (1σ = 2.3 μJy beam^(-1); 0". 75 75) centimetre radio-continuum observations taken by the Karl G. Jansky Very Large Array (VLA)-COSMOS 3 GHz Large Project, we studied the radio-emitting sizes of a flux-limited sample of SMGs in the COSMOS field. The target SMGs were originally discovered in a 1.1 mm continuum survey carried out with the AzTEC bolometer, and followed up with higher resolution interferometric (sub)millimetre continuum observations. Of the 39 SMGs studied here, 3 GHz emission was detected towards 18 of them (~46 ± 11%) with signal-to-noise ratios in the range of S/N = 4.2–37.4. Towards four SMGs (AzTEC2, 5, 8, and 11), we detected two separate 3 GHz sources with projected separations of ~1''5–6''6, but they might be physically related in only one or two cases (AzTEC2 and 11). Using two-dimensional elliptical Gaussian fits, we derived a median deconvolved major axis FWHM size of 0''54±0''11 for our 18 SMGs detected at 3 GHz. For the 15 SMGs with known redshift we derived a median linear major axis FWHM of 4.2 ± 0.9 kpc. No clear correlation was found between the radio-emitting size and the 3 GHz or submm flux density, or the redshift of the SMG. However, there is a hint of larger radio sizes at z ~ 2.5–5 compared to lower redshifts. The sizes we derived are consistent with previous SMG sizes measured at 1.4 GHz and in mid-J CO emission, but significantly larger than those seen in the (sub)mm continuum emission (typically probing the rest-frame far-infrared with median FWHM sizes of only ~1.5–2.5 kpc). One possible scenario is that SMGs have i) an extended gas component with a low dust temperature, which can be traced by low- to mid-J CO line emission and radio continuum emission; and ii) a warmer, compact starburst region giving rise to the high-excitation line emission of CO, which could dominate the dust continuum size measurements. Because of the rapid cooling of cosmic-ray electrons in dense starburst galaxies (~10^4–10^5 yr), the more extended synchrotron radio-emitting size being a result of cosmic-ray diffusion seems unlikely. Instead, if SMGs are driven by galaxy mergers – a process where the galactic magnetic fields can be pulled out to larger spatial scales – the radio synchrotron emission might arise from more extended magnetised interstellar medium around the starburst region.
Impaired Hypothalamic mTOR Activation in the Adult Rat Offspring Born to Mothers Fed a Low-Protein Diet

Several epidemiological and experimental studies have clearly established that maternal malnutrition induces a high risk of developing obesity and related metabolic diseases in the offspring. To determine if altered nutrient sensing might underlie this enhanced disease susceptibility, here we examined the effects of perinatal protein restriction on the activation of the nutrient sensor mTOR in response to acute variations in the nutritional status of the organism. Female Wistar rats were fed isocaloric diets containing either 17% protein (control) or 8% protein (PR) throughout pregnancy and lactation. At weaning offspring received standard chow and at 4 months of age the effects of fasting or fasting plus re-feeding on the phosphorylation levels of mTOR and its downstream target S6 ribosomal protein (rpS6) in the hypothalamus were assessed by immuno-fluorescence and western blot. Under ad libitum feeding conditions, PR rats exhibited decreased mTOR and rpS6 phosphorylation in the arcuate (ARC) and ventromedial (VMH) hypothalamic nuclei. Moreover, the phosphorylation of mTOR and rpS6 in these hypothalamic nuclei decreased with fasting in control but not in PR animals. Conversely, PR animals exhibited enhanced number of pmTOR imunostained cells in the paraventricular nucleus (PVN) and fasting decreased the activation of mTOR in the PVN of malnourished but not of control rats. These alterations occurred at a developmental stage at which perinatally-undernourished animals do not show yet obesity or glucose intolerance. Collectively, our observations suggest that altered hypothalamic nutrient sensing in response to an inadequate foetal and neonatal energetic environment is one of the basic mechanisms of the developmental programming of metabolic disorders and might play a causing role in the development of the metabolic syndrome induced by malnutrition during early life.
Masking Interrupts Figure-Ground Signals in V1

In a backward masking paradigm, a target stimulus is rapidly (<100 msec) followed by a second stimulus. This typically results in a dramatic decrease in the visibility of the target stimulus. It has been shown that masking reduces responses in V1. It is not known, however, which process in V1 is affected by the mask. In the past, we have shown that in V1, modulations of neural activity that are specifically related to figure-ground segregation can be recorded. Here, we recorded from awake macaque monkeys, engaged in a task where they had to detect figures from background in a pattern backward masking paradigm. We show that the V1 figure-ground signals are selectively and fully suppressed at target-mask intervals that psychophysically result in the target being invisible. Initial response transients, signalling the features that make up the scene, are not affected. As figure-ground modulations depend on feedback from extrastriate areas, these results suggest that masking selectively interrupts the recurrent interactions between V1 and higher visual areas.
Transport layer identification of P2P traffic

Since the emergence of peer-to-peer (P2P) networking in the late '90s, P2P applications have multiplied, evolved and established themselves as the leading `growth app' of Internet traffic workload. In contrast to first-generation P2P networks which used well-defined port numbers, current P2P applications have the ability to disguise their existence through the use of arbitrary ports. As a result, reliable estimates of P2P traffic require examination of packet payload, a methodological landmine from legal, privacy, technical, logistic, and fiscal perspectives. Indeed, access to user payload is often rendered impossible by one of these factors, inhibiting trustworthy estimation of P2P traffic growth and dynamics. In this paper, we develop a systematic methodology to identify P2P flows at the transport layer, i.e., based on connection patterns of P2P networks, and without relying on packet payload. We believe our approach is the first method for characterizing P2P traffic using only knowledge of network dynamics rather than any user payload. To evaluate our methodology, we also develop a payload technique for P2P traffic identification, by reverse engineering and analyzing the nine most popular P2P protocols, and demonstrate its efficacy with the discovery of P2P protocols in our traces that were previously unknown to us. Finally, our results indicate that P2P traffic continues to grow unabatedly, contrary to reports in the popular media.
The 46,000-dalton tyrosine protein kinase substrate is widespread, whereas the 36,000-dalton substrate is only expressed at high levels in certain rodent tissues

Proteins of molecular mass 46,000 (p46) and 34,000-39,000 (p36) daltons are phosphorylated at tyrosine in Rous sarcoma virus-transformed chicken and mouse fibroblasts. p46 has recently been identified as an isozyme of enolase but the function of p36 is unknown. The expression of these proteins in various mouse and rat tissues has been examined. In most tissues, except muscle, p46 is found at relatively constant levels. In muscle, a more basic, related protein is present. In contrast, the abundance of p36 varies more widely from tissue to tissue, suggesting that it has a function in some but not all differentiated cells. By SDS gel electrophoresis and immunoblotting, high levels of p36 (60-120% of its relative abundance in fibroblasts) were found in small intestine, lung, and thymus, and intermediate levels (20-50%) were found in spleen, lymph nodes, and testes. No p36 was detectable in brain and muscle. Where studied, p36 mRNA expression paralleled protein levels. The cell types within each tissue expressing p36 were identified by immunofluorescence and immunoperoxidase staining. These cell types include all endothelial cells and fibroblastic cells examined, as well as various epithelial cells, cardiac muscle cells, macrophages, and testicular interstitial cells. We were unable to detect p36 in skeletal or smooth muscle cells, erythrocytes, nerve cells, or lymphocytes in any of the examined tissues. p36 appears to be concentrated in the terminal web region of intestinal columnar epithelial cells.
An Analysis of the Impact of 'Substantially Heightened' Capital Requirements on Large Financial Institutions

We examine the impact of “substantially heightened” capital requirements on large financial institutions, and on their customers. Our analysis yields three main conclusions. First, the frictions associated with raising new external equity finance are likely to be greater than the ongoing costs of holding equity on the balance sheet, implying that the new requirements should be phased in gradually. Second, the long-run steady-state impact on loan rates is likely to be modest, in the range of 25 to 45 basis points for a ten percentage-point increase in the capital requirement. Third, due to the unique nature of competition in financial services, even these modest effects raise significant concerns about migration of credit-creation activity to the shadow-banking sector, and the potential for increased fragility of the overall financial system that this might bring. Thus to avoid tilting the playing field in such a way as to generate a variety of damaging unintended consequences, increased regulation of the shadowbanking sector should be seen as an important complement to the reforms that are contemplated for banks and other large financial institutions. * This research was funded by The Clearing House Association L.L. C.