Miracle-dz/UniFAR-FTUs huggingface dataset:
Microscopy cell counting and detection with fully convolutional regression networks

This paper concerns automated cell counting and detection in microscopy images. The approach we take is to use convolutional neural networks (CNNs) to regress a cell spatial density map across the image. This is applicable to situations where traditional single-cell segmentation-based methods do not work well due to cell clumping or overlaps. We make the following contributions: (i) we develop and compare architectures for two fully convolutional regression networks (FCRNs) for this task; (ii) since the networks are fully convolutional, they can predict a density map for an input image of arbitrary size, and we exploit this to improve efficiency by end-to-end training on image patches; (iii) we show that FCRNs trained entirely on synthetic data are able to give excellent predictions on microscopy images from real biological experiments without fine-tuning, and that the performance can be further improved by fine-tuning on these real images. Finally, (iv) by inverting feature representations, we show to what extent the information from an input image has been encoded by feature responses in different layers. We set a new state-of-the-art performance for cell counting on standard synthetic image benchmarks and show that the FCRNs trained entirely with synthetic data can generalise well to real microscopy images both for cell counting and detections for the case of overlapping cells.
Swelling mechanism of urea cross-linked starch–lignin films in water

ABSTRACT Coating fertilizer particles with thin films is a possibility to control fertilizer release rates. It is observed that novel urea cross-linked starch–lignin composite thin films, prepared by solution casting, swell on coming into contact with water due to the increase in volume by water uptake by diffusion. The effect of lignin content, varied from 0% to 20% in steps of 5% at three different temperatures (25°C, 35°C and 45°C), on swelling of the film was investigated. By gravimetric analysis, the equilibrium water uptake and diffusion coefficient decrease with lignin content, indicating that the addition of lignin increases the hydrophobicity of the films. When temperature increases, the diffusion coefficient and the amount of water absorbed tend to increase. Assuming that swelling of the thin film is by water uptake by diffusion, the diffusion coefficient is estimated. The estimated diffusion coefficient decreases from 4.3 to 2.1 × 10−7 cm2/s at 25°C, from 5.3 to 2.9 × 10−7 cm2/s at 35°C and from 6.2 to 3.8 × 10−7 cm2/s at 45°C depending on the lignin content. Activation energy for the increase in diffusion coefficient with temperature is observed to be 16.55 kJ/mol. An empirical model of water uptake as a function of percentage of lignin and temperature was also developed based on Fick’s law.
Regional Convergence, Polarisation and Mobility in the EU, 1980-1996

The paper deals with three relevant questions for the European Union: the degrees of regional inequality, polarisation and mobility in the per capita regional income distributions between 1980 and 1996. Using different techniques, the paper shows that inter-regional inequality has slightly decreased, there is no apparent polarisation and the degree of mobility is relatively high. Despite this, the speed of all these three aspects has declined over time, which is interesting for polarisation but raises some worries about convergence and mobility for the future.
Randomised clinical trial: sofosbuvir and ledipasvir in patients with transfusion‐dependent thalassaemia and HCV genotype 1 or 4 infection

Patients with thalassaemia major depend on blood transfusions. In Italy, up to 80% of thalassaemia patients bear HCV antibodies due to HCV contaminated transfusions before 1990. Thalassaemia patients with HCV infection have high risk of developing HCC. Treatment based on Pegylated‐IFN (Peg‐IFN) and Ribavirin (RBV) was limited by relevant side effects.
The development and correlates of gender role attitudes in African American youth

This research examined the longitudinal trajectories and family correlates of gender role attitudes in African American youth in a sample of 166 sibling pairs residing with their mothers and fathers. Multilevel modelling revealed that (1) girls and boys exhibited significant declines in gender attitude traditionality from ages 9 to 15 that levelled off through age 18, (2) mothers' (but not fathers') gender role attitude traditionality was positively related to youth's attitude traditionality, and (3) within-person variation in mothers' (but not fathers') racial discrimination experiences was negatively related to within-person variation in youth's gender role attitude traditionality. The utility of applying a cultural ecological framework within an ethnic homogenous, accelerated longitudinal design to understand African American family processes, in conjunction with the intersectionality between race and gender, is the focus of the discussion. Statement of contribution What is already known on this subject? Gender role attitude traditionality declined for girls, but not for boys, in European and Mexican American families. Little is known about the roles of African American parents in shaping their children's gender development. What does this study add? For African American girls and boys, gender role attitude traditionality declined from ages 9 to 15 and then levelled off through age 18. At the between-person level, African American mothers', but not fathers', attitude traditionality was positively linked to that of their children. At the within-person level, African American mothers', but not fathers', experiences of racial discrimination were negatively linked to their children's attitude traditionality.
Impact of the malaria parasite on reproductive indices of male mice

AimTo investigate the impact and possible mechanism of action of the rodent malarial parasite on reproduction.MethodsMale albino mice were infected with 15, 30 and 45% Plasmodium berghei berghei through inoculation with 107 parasitized red blood cells. Each experiment had its own control that was not infected with P. berghei berghei. Mice infected with 15% P. berghei berghei were killed on days 0, 5, 10 and 15; those infected with 30% P. berghei berghei were killed on days 0, 3, 6 and 10; and those infected with 45% P. berghei berghei were killed on days 1–7 after infection. Caudal epididymal sperm motility counts and morphology body and wet organ weights and hematological indices were determined.ResultsThe results showed a progressive duration dependent decrease in sperm motility sperm count and viability (P < 0.01) in parasitized mice. There were significant decreases in serum testosterone and increases in cortisol levels (P < 0.05) in the infected mice compared with the controls. There was also a progressive decrease (P < 0.05) in red blood cell count and packed cell volume. However, there was a progressive increase (P < 0.01) in white blood cell count and weight of the spleen and liver. There was no significant change in weight of the testis and epididymides.ConclusionThe results suggest that the malaria parasite could depress male fertility indices.
Stakeholders’ Voices: Defining Needs of Students with Emotional and Behavioral Disorders Transitioning between School Settings

Students with emotional and behavioral disorders (EBD) too often do not receive adequate services or care in their school settings, particularly during transitions in educational placements. In addition, school support teams often struggle with creating transition plans that honor the needs of students with input from key stakeholders responsible for supporting student success. This article presents findings from the information-gathering phase of an iterative project that aims to develop a support program for students with EBD transitioning from day-treatment schools to district schools. We conducted 5 semistructured, qualitative focus groups with parents and teachers to explore needs during students’ transitions between school settings. Five themes emerged from the focus groups: (a) consistent, behavior-specific feedback and positive reinforcement are vital to sustaining learned prosocial skills; (b) students benefit from regular opportunities to learn and practice social skills; (c) transition programming should emphasize communication between school and home; (d) routines at home and school should be coordinated; and (e) parents need support at school meetings. We will use findings from this study to develop a multifaceted intervention that aims to support students, their caregivers, and their teachers during transitions between the aforementioned types of schools.
HIV and HCV Cooperatively Promote Hepatic Fibrogenesis via Induction of Reactive Oxygen Species and NFκB*

HIV/HCV coinfection leads to accelerated hepatic fibrosis progression, with higher rates of cirrhosis, liver failure, and liver death than does HCV mono-infection. However, the profibrogenic role of HIV on hepatocytes and hepatic stellate cells (HSC) has not been fully clarified. We hypothesized that HIV, HCV induce liver fibrosis through altered regulation of the production of extracellular matrix and matrix metalloproteinases. We examined the fibrogenesis- and fibrolysis-related gene activity in LX2 HSC and Huh7.5. 1 cells in the presence of inactivated CXCR4 and CCR5 HIV, as well as HCV JFH1 virus. The role of reactive oxygen species (ROS) upon fibrosis gene expression was assessed using the ROS inhibitor. Fibrosis-related transcripts including procollagen α1(I) (CoL1A), TIMP1, and MMP3 mRNA were measured by qPCR. TIMP1 and MMP3 protein expression were assessed by ELISA. We found that inactivated CXCR4 HIV and CCR5 HIV increased CoL1A, and TIMP1 expression in both HSC and Huh7.5. 1 cells; the addition of JFH1 HCV further increased CoL1A and TIMP1 expression. CXCR4 HIV and CCR5 HIV induced ROS production in HSC and Huh7.5. 1 cells which was further enhanced by JFH1 HCV. The ROS inhibitor DPI abrogated HIV-and HCV-induced CoL1A and TIMP1 expression. HIV and HCV-induced CoL1A and TIMP1 expression were also blocked by NFκB siRNA. Our data provide further evidence that HIV and HCV independently regulate hepatic fibrosis progression through the generation of ROS; this regulation occurs in an NFκB-dependent fashion. Strategies to limit the viral induction of oxidative stress are warranted to inhibit fibrogenesis.
Down Payment Saving in the United States: Evidence from the Panel Study of Income Dynamics

We present a model of household saving toward a mortgage loan under an exogenous down payment requirement and preference for owning over renting. Our model explains a set of empirical observations such as the dual effect in the form of some households, in response to higher down payments, becoming discouraged savers while those who do not abandon purchasing plans save more. We also employ instrumental variable-based methods to investigate the down payment saving behavior of first-time home buyers in the United States. The empirical results based on Panel Study of Income Dynamics (PSID) data support the inelastic down payment elasticity of saving implied by our model.
“THE ROARING NINETIES”: A COMMENT ON THE STATE OF ACCOUNTING HISTORY IN THE UNITED STATES

This comment on a recent contribution by Fleischman and Radcliffe [2005], entitled “The Roaring Nineties: Accounting History Comes of Age,” specifically deals with their cautionary comments on the general condition of accounting history research in the U.S. around the close of that decade. The author contends that public interest in accounting's past is currently strong, especially following the recent corporate scandals and audit failures in the U.S., and points out that accounting history research projects which are of relevance to policy makers and regulators are likely to be both funded and, accordingly, recognized.
Noroviruses as a Cause of Diarrhea in Travelers to Guatemala, India, and Mexico

ABSTRACT Noroviruses (NoVs) are increasingly being recognized as an important enteric pathogen of gastroenteritis worldwide. The prevalence of NoVs as a cause of diarrhea acquired by travelers in developing countries is not well known. We examined the prevalence and importance of NoV infection in three international traveler cohorts with diarrhea acquired in three developing regions of the world, Mexico, Guatemala, and India. We also characterized the demographics and symptoms associated with NoV diarrhea in these travelers. Stool samples from 571 international travelers with diarrhea were evaluated for traditional enteropathogens. NoVs were identified using reverse transcription-PCR and probe hybridization. NoVs were identified in 10.2% of cases of travelers' diarrhea and, overall, was the second most common pathogen, following diarrheagenic Escherichia coli. The detection of NoV diarrhea significantly varied over the three study time periods in Guadalajara, Mexico, ranging from 3 of 98 (3.0%) diarrheal stools to 12 of 100 (12.0%) fecal specimens (P = 0.03). The frequency of NoV diarrhea was also dependent upon the geographic region, with 17 of 100 (17.0%) travelers to Guatemala, 23 of 194 (11.9%) travelers to India, and 3 of 79 (3.8%) travelers to Mexico testing positive for NoVs from 2002 to 2003 (P = 0.02). NoVs are important pathogens of travelers' diarrhea in multiple regions of the world. Significant variation in the prevalence of NoV diarrhea and in the predominant genogroup infecting travelers was demonstrated, dependent upon the specific geographic location and over time.
Competitive implications of information technology in the public sector

Increased use of market mechanisms in the delivery of public services is one of the major attempts made by governments to achieve greater efficiency, higher quality and a clearer focus on customers. Information systems (ISs) can promote the adoption of market mechanisms, but they can also preserve a monopolistic and hierarchic model of service delivery. Hence, understanding the competitive implications of information technology (IT) is becoming relevant for managers in the public sector as well. Provides a brief overview of previous research on IT‐based competition and discusses its relevance for public sector management. Then continues to describe a project where six offices of one city co‐operated in developing a shared geographic information system (GIS). While this research is based on an in‐depth analysis of only one case, other researchers have reported similar experiences. It appears that effective use of market mechanisms in the public sector requires new orientation in IS planning and rethinking of the role of IS departments in public sector organisations.
Do late preterm twins face an increased neonatal morbidity compared with singletons?

OBJECTIVE Late preterm infants (born between 34 0/7 and 36 6/7 weeks of gestation) have been shown to have a higher morbidity and mortality than term infants. Furthermore, twins, both term and preterm, have a higher neonatal morbidity than singletons. The aim of our study was to examine if late preterm twins consequently have twice the neonatal morbidity when both risk factors prematurity and multiple pregnancy are present. STUDY DESIGN A retrospective single-centre study was conducted to compare neonatal outcome of late preterm singletons and late preterm twins born between 34 0/7 and 36 6/7 weeks of gestation as well as term twins with a gestational age from 37 0/7 to 41 6/7 weeks. Primary outcome was length of hospitalisation. Secondary outcome was neonatal morbidity. RESULTS A total of 845 infants were included. Late preterm twins (n = 243) were hospitalised significantly longer than term twins (n = 107) (13.5 ± 8.0 vs 6.29 ± 2.0 days, p <0.001) and late preterm singletons (n = 495) (13.5 ± 8.0 vs 12.6 ± 8.6 days, p = 0.011). Hyperbilirubinaemia occurred significantly more often in late preterm singletons than in late preterm twins (49.7 vs 29.2%; p<0.001). Otherwise, no significant differences were detected regarding neonatal morbidities or mortality of late preterm singletons and late preterm twins. Late preterm twins had a significantly higher incidence of most morbidities than term twins. CONCLUSION Late preterm twins are hospitalised significantly longer than similar-aged singletons, but have otherwise similar neonatal morbidities. Hyperbilirubinaemia is less frequent in late preterm twins than late preterm singletons.
Native American Race, Use of the Indian Health Service, and Breast and Lung Cancer Survival in Florida, 1996–2007

We evaluated associations of race, primary payer at diagnosis, and survival among patients diagnosed in Florida with lung cancer (n = 148,140) and breast cancer (n = 111,795), from 1996 through 2007. In multivariate models adjusted for comorbidities, tumor characteristics, and treatment factors, breast cancer survival was worse for Native American women than for white women (hazard ratio [HR], 1.52; 95% confidence interval [CI], 1.05–2.20) and for women using the Indian Health Service than for women using private insurance (HR, 1.71; 95% CI, 1.33–2.19). No survival association was found for Native American compared with white lung cancer patients or those using the Indian Health Service versus private insurance in fully adjusted models. Additional resources are needed to improve surveillance strategies and to reduce cancer burden in these populations.
Clients’ experiences of housing adaptations: a longitudinal mixed-methods study

Purpose: To explore clients’ experience of the housing adaptations (HAs) over time in relation to housing and health. Method: A multiple longitudinal case study, employing an embedded mixed-method design was used. Four participants were included and data from semi-structured interviews were combined with data from structured survey assessments. Results: HA made it possible to maintain valuable roles and activities, to continue to live in the participants’ own homes and to take part in the society. The participants strived for autonomy and control, and in order to do so they needed different kinds of support, in terms of HA and mobility devices as well as support from professionals. HA also challenged the participants’ routines and habits, as well as their perception about how an appealing HA aesthetically. Thus, the decision to apply for a HA was not always straightforward. Instead, the participants were constantly engaged in negotiations with themselves, concerning benefits and drawbacks of different decisions. Conclusions: HAs involve complex person–environment–activity (P-E-A) transactions, and enhance clients’ activity and independence in spite of functional decline. The knowledge generated is important in order to improve individual HA, as well as improving the efficiency and effectiveness of the intervention. Implications for Rehabilitation Clients need different kinds of support from professionals. Clients needs and preferences should be at the forefront throughout the housing adaptation process. Clients individual meaning of the housing adapation as well as the social environment are important aspects.
Feedback Loop Effects in Payment Card Markets: Empirical Evidence

While some studies have assumed that mature and well-established platforms do not exhibit feedback loop effects, other recent contributions have suggested that these effects may exist. Using a unique database that provides detailed information on both cardholder and merchant sides of the Spanish payment card market, we find empirical evidence of feedback loop effects. We also offer some evidence on the relative value that consumers (merchants) place on network characteristics such as the degree of merchant acceptance (cardholder adoption) and prices.
Economic Factors, Monetary Policy, and Expected Returns on Stocks and Bonds

This paper examines the impact of the stance of monetary policy on security returns. The two measures of the stance of monetary policy used, the federal funds rate and an index based on the changes in the discount rate, contain significant information that can be used to forecast expected stock and bond portfolio returns. Specifically, we find that a restrictive (expansive) monetary policy stance decreases (increases) returns of large and small stock portfolios and in some cases, corporate bond portfolios. The monetary policy stance measures have explanatory power in forecasting stock and bond returns, beyond the business conditions proxies.
Measurement of brain glutamate using TE‐averaged PRESS at 3T

A method is introduced that provides improved in vivo spectroscopic measurements of glutamate (Glu), glutamine (Gln), choline (Cho), creatine (Cre), N‐acetyl compounds (NAtot, NAA + NAAG), and the inositols (mI and sI). It was found that at 3T, TE averaging, the f1 = 0 slice of a 2D J‐resolved spectrum, yielded unobstructed signals for Glu, Glu + Gln (Glx), mI, NAtot, Cre, and Cho. The C4 protons of Glu at 2.35 ppm, and the C2 protons of Glx at 3.75 ppm were well resolved and yielded reliable measures of Glu/Gln stasis. Apparent T1/T2 values were obtained from the raw data, and metabolite tissue levels were determined relative to a readily available standard. A repeatibility error of <5%, and a coefficient of variation (CV) of <10% were observed for brain Glu levels in a study of six normal volunteers. Magn Reson Med 51:435–440, 2004. © 2004 Wiley‐Liss, Inc.
Normative Influences on Secondary Disturbance: The Role of Social Expectancies

A “new wave” within psychotherapy has introduced the concept of acceptance into people's emotional repertoires. Accepting unpleasant emotional states has been demonstrated as an important pathway towards reducing secondary disturbances and improving emotional and psychological functioning. What is often overlooked, however, is whether this move towards acceptance is reinforced within the social and cultural contexts in which people experience their emotional states. Our research has begun to explore the contribution that normative influences make to secondary disturbance, specifically the perception that feeling happy is a desired state, and that experiencing and expressing negative emotions is undesirable and unacceptable to others. We review evidence here that these perceived “social expectancies” are associated with increased negative emotionality and depression, and reduce well‐being. Furthermore, we highlight that the effects of social expectancies are more apparent in Australia than Japan, consistent with the view that a higher premium is placed on happiness within Australia. We also review experimental evidence that social messages that reinforce these social expectancies serve to increase secondary disturbances. The implications of taking a social perspective on emotion regulation and dysfunction, and specifically implications for promoting happiness and acceptance in the field, are discussed.
Reinforcement Learning and Control as Probabilistic Inference: Tutorial and Review

The framework of reinforcement learning or optimal control provides a mathematical formalization of intelligent decision making that is powerful and broadly applicable. While the general form of the reinforcement learning problem enables effective reasoning about uncertainty, the connection between reinforcement learning and inference in probabilistic models is not immediately obvious. However, such a connection has considerable value when it comes to algorithm design: formalizing a problem as probabilistic inference in principle allows us to bring to bear a wide array of approximate inference tools, extend the model in flexible and powerful ways, and reason about compositionality and partial observability. In this article, we will discuss how a generalization of the reinforcement learning or optimal control problem, which is sometimes termed maximum entropy reinforcement learning, is equivalent to exact probabilistic inference in the case of deterministic dynamics, and variational inference in the case of stochastic dynamics. We will present a detailed derivation of this framework, overview prior work that has drawn on this and related ideas to propose new reinforcement learning and control algorithms, and describe perspectives on future research.