Miracle-dz/UniFAR-FTUs huggingface dataset:
The processing of homographic morphemes in Chinese: an ERP study

ABSTRACT The processing of homographic morphemes during Chinese word recognition was investigated by recording event-related potentials (ERPs) in a masked priming lexical decision experiment. There were four conditions. In the morpheme condition, the homographic morphemes in primes and targets had the same interpretations (e.g. “公園-public garden/park” and “公眾-public people/the public”). In the homograph condition, they had different interpretations (e.g. “公雞-male chicken/cock”). Semantic-sharing (e.g. “草地-lawn”) and unrelated (e.g. “嗅覺-olfaction”) conditions were also included. Compared to the unrelated condition, the morpheme and homograph primes produced a comparable P200. In contrast, N400 priming was identified only in the morpheme condition. Semantic sharing produced relatively weaker effects. These findings indicate that homographic morphemes are activated during word recognition even though in principle, whole-word processing is more efficient. The results are discussed with reference to morpho-orthographic and morpho-semantic processing.
Formation of highly oxygenated organic aerosol in the atmosphere: Insights from the Finokalia Aerosol Measurement Experiments

Aged organic aerosol (OA) was measured at a remote coastal site on the island of Crete, Greece during the Finokalia Aerosol Measurement Experiments (FAME‐08 and FAME‐09), which were part of the EUCAARI intensive campaigns. Quadrupole aerosol mass spectrometers (Q‐AMSs) were employed to measure the size‐resolved chemical composition of non‐refractory submicron aerosol (NR‐PM1), and to estimate the extent of oxidation of the OA. The experiments provide unique insights into ambient oxidation of aerosol by measuring at the same site but under different photochemical conditions. NR‐PM1 concentrations were about a factor of three lower during FAME‐09 (winter) than during FAME‐08 (summer). The OA sampled was significantly less oxidized and more variable in composition during the winter than during the early summer. Lower OH concentrations in the winter were the main difference between the two campaigns, suggesting that atmospheric formation of highly oxygenated OA is associated with homogeneous photochemical aging.
Alterations of Dermal Connective Tissue Collagen in Diabetes: Molecular Basis of Aged-Appearing Skin

Alterations of the collagen, the major structural protein in skin, contribute significantly to human skin connective tissue aging. As aged-appearing skin is more common in diabetes, here we investigated the molecular basis of aged-appearing skin in diabetes. Among all known human matrix metalloproteinases (MMPs), diabetic skin shows elevated levels of MMP-1 and MMP-2. Laser capture microdissection (LCM) coupled real-time PCR indicated that elevated MMPs in diabetic skin were primarily expressed in the dermis. Furthermore, diabetic skin shows increased lysyl oxidase (LOX) expression and higher cross-linked collagens. Atomic force microscopy (AFM) further indicated that collagen fibrils were fragmented/disorganized, and key mechanical properties of traction force and tensile strength were increased in diabetic skin, compared to intact/well-organized collagen fibrils in non-diabetic skin. In in vitro tissue culture system, multiple MMPs including MMP-1 and MM-2 were induced by high glucose (25 mM) exposure to isolated primary human skin dermal fibroblasts, the major cells responsible for collagen homeostasis in skin. The elevation of MMPs and LOX over the years is thought to result in the accumulation of fragmented and cross-linked collagen, and thus impairs dermal collagen structural integrity and mechanical properties in diabetes. Our data partially explain why old-looking skin is more common in diabetic patients.
Revisiting and-inverter cones

And-Invert Cones (AICs) have been suggested as an alternative to the ubiquitous Look-Up Tables (LUTs) used in commercial FPGAs. The original article suggesting the new architecture made some untested assumptions on the circuitry needed to implement AIC architectures and did not develop completely the toolset necessary to assess comprehensively the idea. In this paper, we pick up the architecture that some of us proposed in the original AIC paper and try to implement it as thoroughly as we can afford. We build all components for the logic cluster at transistor level in a 40~nm technology as well as a LUT-based architecture inspired by Altera's Stratix~IV. We first determine that the characteristics of our LUT-based architecture are reasonably similar to those of the commercial counterpart. Then, we compare the AIC architecture to the baseline on a number of benchmarks, and we find a few difficulties that had been overlooked before. We thus explore other design possibilities around the original design point and show their detailed impact. Finally, we discuss how the very structure of current logic clusters seems not perfectly appropriate for getting the best out of AICs and conclude that, even though they are not confirmed as an immediate blessing today, AICs still offer rich research opportunities.
The State-of-the-Art of Preconditioners for Sparse Linear Least-Squares Problems

In recent years, a variety of preconditioners have been proposed for use in solving large sparse linear least-squares problems. These include simple diagonal preconditioning, preconditioners based on incomplete factorizations, and stationary inner iterations used with Krylov subspace methods. In this study, we briefly review preconditioners for which software has been made available, then present a numerical evaluation of them using performance profiles and a large set of problems arising from practical applications. Comparisons are made with state-of-the-art sparse direct methods.
College Student Cyberbullying: Self‐Esteem, Depression, Loneliness, and Attachment

In an online survey (N = 338) at a large midwestern university, frequency counts indicated that 51 (15.1%) undergraduate students were cyberbully victims during college, and 27 (8.0%) were cyberbully offenders during college. In simultaneous regressions, maternal attachment anxiety explained unique variance in cybervictimization and cyberoffending. In multivariate analyses of variance, cyberbully victims (vs. nonvictims) reported higher depression, loneliness, and maternal attachment anxiety, and cyberbully offenders (vs. nonoffenders) reported lower self-esteem and higher maternal attachment anxiety. College counseling implications are discussed.
Investigation of 3- to 4-Year-Old Children’s Interaction with Literacy Teaching Apps

This study investigated use of iPad apps in young children’s literacy learning. This study has two phases: app appraisal phase, and the child play phase. In the app appraisal phase, this study chose five available apps from the iTune recommended website. A GIARS rating scale was used to appraise the chosen apps in 10 areas in GIARS: age appropriateness, contextual environment, spatial design, seamlessness, scaffolding, non-violence, process orientation, real world model, and the anatomy of a gesture. In the child play phase, five 3-4 year old young children were observed while playing the apps to learn literacy. Early childhood educators and technician app developers will find this paper useful in conceptualising appropriate apps in young children’s literacy learning.
Genetic Loci That Influence Cause of Death in a Heterogeneous Mouse Stock

Abstract A genome scan was conducted to seek evidence for polymorphic genes that influence cause of death in mice produced by a cross between CB6F1 females and C3D2F1 males. Loci on chromosomes 1 and 4 were found to modulate risk of lymphoma. A locus on chromosome 4 influenced risk of mammary adenocarcinoma among multiparous female mice, but had no significant effect in virgin females. A chromosome 4 locus was found to modulate risk of death from either hemangiosarcoma or fibrosarcoma. A suggestive linkage was noted (at p =.09) between a marker on chromosome 11 and hepatocellular carcinoma. Lastly, a locus on chromosome 6 was noted to influence the likelihood that pulmonary adenocarcinoma would be present at death. The collection of normal and neoplastic tissues from 1004 terminal necropsies, together with genetic information, provides a valuable resource for further studies of the genetic influences on late-life diseases in mice.
Prognostic Significance and Clinicopathological Associations of COX-2 SNP in Patients with Nonsmall Cell Lung Cancer

Background. To further improve the screening, diagnosis, and therapy of patients with nonsmall cell lung cancer (NSCLC) additional diagnostic tools are urgently needed. Gene expression of Cyclooxygenase-2 (COX-2) has been linked to prognosis in patients with NSCLC. The role of the COX-2 926G>C Single Nucleotide Polymorphism (SNP) in patients with NSCLC remains unclear. The aim of this study was to investigate the potential of the COX-2 926G>C SNP as a molecular marker in this disease. Methods. COX-2 926G>C SNP was analyzed in surgically resected tumor tissue of 85 patients with NSCLC using a PCR-based RFLP technique. Results. The COX-2 926G>C SNP genotypes were detected with the following frequencies: GG n = 62 (73%), GC n = 20 (23%), CC n = 3 (4%). There were no associations between COX-2 SNP genotype and histology, grading or gender detectable. COX-2 SNP was significantly associated with tumor stage (P = .032) and lymph node status (P = .016, Chi-square test). With a median followup of 85.9 months, the median survival was 59.7 months. There were no associations seen between the COX-2 SNP genotype and patients prognosis. Conclusions. The COX-2 926G>C SNP is detectable at a high frequency in patients with NSCLC. The COX-2 926G>C SNP genotype is not a prognostic molecular marker in this disease. However, patients with the GC or CC genotype seem more susceptible to lymph node metastases and higher tumor stage than patients with the GG genotype. The results suggest COX-2 926G>C SNP as a molecular marker for lymph node involvement in this disease.
The Analysis of the 5th Grade Students' Attitudes and Self-Efficacy for Physical Education Course in Terms of Demographic Characteristics.

The aim of the study is to analyze the 5 th grade students’ attitudes and self-efficacy for the physical education course that they have come across for the first time which is taught by physical education and sports teachers. Law No. 6287 was issued by the Turkish Grand National Assembly National Education Culture Youth and Sports Commission on March 30, 2012 and put in the practice on April 11, 2012. It enforced compulsory education system from 8 years to 12 years and graded the education system as 4 + 4 + 4 years (URL-1). 329 fifth grade students studying at 13 public schools in the districts and villages of Rize and Trabzon cities joined the study. In addition to the Personal Information Form, “Physical Education Susceptibility Scale” (PESS) developed by Hilland et al. (2009) and adapted to Turkish by Oncu, Gurbuz, Kucukkilic and Keskin (2015) checking its validity and reliability as a data collection tool covering 11 items were used. According to the findings of the analysis made for the "Attitude" subtitle of the 5th grade students towards physical education course; "Gender Variable" (t = 2,211; p <0.05) had a significant difference compared to "Location of School" (F = 3,044; p <0,05). In addition, according to the findings of the analysis made for the "Self-efficacy" subtitle for the physical education course of the 5th grade students, there was a significant difference in terms of “Mother’s Educational Level” (F = 2,766; p <0,05). The difference was meaningful between the groups of elementary school-post graduate, and high school-secondary school.
The Influence of Intellectual Capital on the Growth of Small and Medium Enterprises in Kenya

Small and medium enterprises in kenya represent a vital part of the economy, being the source of various economic contributions through; the generation of income via exporting, providing new job opportunities, introducing innovations, stimulating competition, and engine for employment. Intellectual capital appears as the most important and vital component of a knowledge-based eeconomy. The role and importance of small and medium enterprises in a knowledge-based economy has been highly appreciated and acknowledged. Moreover, in the present economy, small and medium enterprise are facing tremendous challenges and threats to survive in a competitive environment. The impact of intellectual capital on the general performance of the Small and medium enterprises has become a very important issue now than ever, this is due to the level of globalization of whose outcomes are privatization and deregulation of markets, aggressive competition and the ever-rising expectations of customers. As a result of this, there is need for businesses to be at their best in order to be relevant in the environment. The paper therefore examines the influence of intellectual capital and growth of small and medium enterprise in Kenya. Most of the studies conducted on the role of intellectual capital have focused on the developed countries outside Africa. It is therefore imperative to explore the role of intellectual capital on this important sector of the economy. From the findings, management’s technical skills influenced the growth of small and medium enterprise, mostly followed by managerial experience. Further, the drive/impetus to entrepreneurship influenced the growth of small and medium enterprise mostly followed by risk taking propensity among all the entrepreneurial skills factors.
Positional views as the cornerstone of Sen’s idea of justice

Our paper offers a novel reading of Sen's idea of justice, beyond the standard prisms imposed by theories of justice-resting on external normative criteria-and formal welfarism-involving the definition of individual welfare and its aggregation. Instead we take seriously Sen's emphasis on personal agency and focus on his original contribution to the issue of objectivity. Firstly, we demonstrate that Sen's idea of justice, with at its core "positional views", is more respectful of persons' agency than would be a theory based on individual preference or capability. Secondly, we argue that Sen's conception of objectivity considers that both information and sentiments are relative to a position. Such an alternative approach to subjectivity allows the formation of more impartial views through collective deliberation and a better consideration of justice by agents themselves.
The Cellular Localization of Human Cytomegalovirus Glycoprotein Expression Greatly Influences the Frequency and Functional Phenotype of Specific CD4+ T Cell Responses

CMV infection is a significant cause of morbidity and mortality in immunocompromised individuals, and the development of a vaccine is of high priority. Glycoprotein B (gB) is a leading vaccine candidate but the glycoprotein H (gH) pentameric complex is now recognized as the major target for neutralizing Abs. However, little is known about the T cell immune response against gH and glycoprotein L (gL) and this is likely to be an important attribute for vaccine immunogenicity. In this study, we examine and contrast the magnitude and phenotype of the T cell immune response against gB, gH, and gL within healthy donors. gB-specific CD4+ T cells were found in 95% of donors, and 29 epitopes were defined with gB-specific response sizes ranging from 0.02 to 2.88% of the CD4+ T cell pool. In contrast, only 20% of donors exhibited a T cell response against gH or gL. Additionally, gB-specific CD4+ T cells exhibited a more cytotoxic phenotype, with high levels of granzyme B expression. Glycoproteins were effectively presented following delivery to APCs but only gB-derived epitopes were presented following endogenous synthesis. gB expression was observed exclusively within vesicular structures colocalizing with HLA-DM whereas gH was distributed evenly throughout the cytoplasm. Grafting of the C-terminal domain from gB onto gH could not transfer this pattern of presentation. These results reveal that gB is a uniquely immunogenic CMV glycoprotein and this is likely to reflect its unique pattern of endogenous Ag presentation. Consideration may be required toward mechanisms that boost cellular immunity to gH and gL within future subunit vaccines.
Uncertainty in visual and auditory series is coded by modality‐general and modality‐specific neural systems

Coding for the degree of disorder in a temporally unfolding sensory input allows for optimized encoding of these inputs via information compression and predictive processing. Prior neuroimaging work has examined sensitivity to statistical regularities within single sensory modalities and has associated this function with the hippocampus, anterior cingulate, and lateral temporal cortex. Here we investigated to what extent sensitivity to input disorder, quantified by Markov entropy, is subserved by modality‐general or modality‐specific neural systems when participants are not required to monitor the input. Participants were presented with rapid (3.3 Hz) auditory and visual series varying over four levels of entropy, while monitoring an infrequently changing fixation cross. For visual series, sensitivity to the magnitude of disorder was found in early visual cortex, the anterior cingulate, and the intraparietal sulcus. For auditory series, sensitivity was found in inferior frontal, lateral temporal, and supplementary motor regions implicated in speech perception and sequencing. Ventral premotor and central cingulate cortices were identified as possible candidates for modality‐general uncertainty processing, exhibiting marginal sensitivity to disorder in both modalities. The right temporal pole differentiated the highest and lowest levels of disorder in both modalities, but did not show general sensitivity to the parametric manipulation of disorder. Our results indicate that neural sensitivity to input disorder relies largely on modality‐specific systems embedded in extended sensory cortices, though uncertainty‐related processing in frontal regions may be driven by both input modalities. Hum Brain Mapp 35:1111–1128, 2014. © 2013 Wiley Periodicals, Inc.
History of falling and visual ability among independently living elderly in Sweden

Purpose The aim of this study was to assess the performance-based visual ability among independently living elderly subjects and to investigate whether there was any association between visual ability and falls. Subjects and methods A total of 298 randomly selected subjects aged 70–85 years were invited for an examination including monocular and binocular visual acuity (VA), contrast sensitivity (CS), stereoscopic vision, and monocular visual fields (VFs), which were integrated to estimate the binocular VFs. Type of lenses used in their habitual correction was noted. Results Out of the 212 subjects who were examined, 38% reported at least one fall and 48% of these reported at least two falls during the last 2 years. Most subjects had normal results; 90% had normal binocular VA, 85% had normal binocular CS, and ~80% had positive stereopsis. Twenty-nine subjects had VF defects in the lower quadrants of the binocular VF, and 14 of these reported at least one fall. A significant association was seen between one fall or more and VA better eye, the odds ratio (OR) was 2.26, P=0.013, and between recurrent falls and lack of stereoscopic vision, the OR was 3.23, P=0.002; no other functional test showed any significant association with recurrent falls. The ORs were 1.58 for worse binocular VA, 0.60 for worse binocular CS, and 0.71 for non-normal stereoscopic vision for at least one fall, but wide confidence intervals made it difficult to draw firm conclusions about any association. Bifocal or progressive spectacles were worn by 71% with no significant difference between fallers and nonfallers (P=0.078). Conclusion Even though ~40% of the total sample had experienced one or more falls, the only visual function test significantly associated with falls were VA better eye, lack of stereoscopic vision, and recurrent falls. Our results suggest that there may be more powerful predictors of falling than decreased visual ability.
Optogenetic Control of PIP3: PIP3 Is Sufficient to Induce the Actin-Based Active Part of Growth Cones and Is Regulated via Endocytosis

Phosphatidylinositol-3,4,5-trisphosphate (PIP3) is highly regulated in a spatiotemporal manner and plays multiple roles in individual cells. However, the local dynamics and primary functions of PIP3 in developing neurons remain unclear because of a lack of techniques for manipulating PIP3 spatiotemporally. We addressed this issue by combining optogenetic control and observation of endogenous PIP3 signaling. Endogenous PIP3 was abundant in actin-rich structures such as growth cones and “waves”, and PIP3-rich plasma membranes moved actively within growth cones. To study the role of PIP3 in developing neurons, we developed a PI3K photoswitch that can induce production of PIP3 at specific locations upon blue light exposure. We succeeded in producing PIP3 locally in mouse hippocampal neurons. Local PIP3 elevation at neurite tips did not induce neurite elongation, but it was sufficient to induce the formation of filopodia and lamellipodia. Interestingly, ectopic PIP3 elevation alone activated membranes to form actin-based structures whose behavior was similar to that of growth-cone-like “waves”. We also found that endocytosis regulates effective PIP3 concentration at plasma membranes. These results revealed the local dynamics and primary functions of PIP3, providing fundamental information about PIP3 signaling in neurons.
The Largest Blueshifts of the [O III] Emission Line in Two Narrow-Line Quasars

We have obtained optical intermediate-resolution spectra (R = 3000) of the narrow-line quasars DMS 0059-0055 and PG 1543+489. The [O III] emission line in DMS 0059-0055 is blueshifted by 880 km s-1 relative to Hβ. We also confirm that the [O III] emission line in PG 1543+489 has a relative blueshift of 1150 km s-1. These two narrow-line quasars show the largest [O III] blueshifts known to date among type 1 active galactic nuclei (AGNs). The [O III] emission lines in both objects are broad (1000-2000 km s-1), and those in DMS 0059-0055 show strong blue asymmetry. We interpret the large blueshift and the profile of the [O III] lines as the result of an outflow interacting with circumnuclear gas. Among type 1 AGNs with large blueshifted [O III], there is no correlation between the Eddington ratios and the amount of [O III] blueshift. Combining our new data with published results, we confirm that the Eddington ratios of such AGNs are the highest among AGNs with the same black hole mass. These facts suggest that the Eddington ratio is a necessary condition for [O III] blueshifts or that the [O III] blueshifts weakly depend on the Eddington ratio. Our new sample suggests that there are possibly other necessary conditions to produce an outflow than a high Eddington ratio: a large black hole mass (>107 M☉), a high mass accretion rate (>2 M☉ yr-1), or a large luminosity [λLλ(5100 Å) > 1044.6 ergs s-1].