Miracle-dz/UniFAR-FTUs huggingface dataset:
Open pore biodegradable matrices formed with gas foaming.

Engineering tissues utilizing biodegradable polymer matrices is a promising approach to the treatment of a number of diseases. However, processing techniques utilized to fabricate these matrices typically involve organic solvents and/or high temperatures. Here we describe a process for fabricating matrices without the use of organic solvents and/or elevated temperatures. Disks comprised of polymer [e.g., poly (D,L-lactic-co-glycolic acid)] and NaCl particles were compression molded at room temperature and subsequently allowed to equilibrate with high pressure CO2 gas (800 psi). Creation of a thermodynamic instability led to the nucleation and growth of gas pores in the polymer particles, resulting in the expansion of the polymer particles. The polymer particles fused to form a continuous matrix with entrapped salt particles. The NaCl particles subsequently were leached to yield macropores within the polymer matrix. The overall porosity and level of pore connectivity were regulated by the ratio of polymer/salt particles and the size of salt particles. Both the compressive modulus (159+/-130 kPa versus 289+/-25 kPa) and the tensile modulus (334+/-52 kPa versus 1100+/-236 kPa) of the matrices formed with this approach were significantly greater than those formed with a standard solvent casting/particulate leaching process. The utility of these matrices was demonstrated by engineering smooth muscle tissue in vitro with them. This novel process, a combination of high pressure gas foaming and particulate leaching techniques, allows one to fabricate matrices with a well controlled porosity and pore structure. This process avoids the potential negatives associated with the use of high temperatures and/or organic solvents in biomaterials processing.
ADHD symptoms and the teacher–student relationship: a systematic literature review

ABSTRACT This systematic review integrates the existing literature regarding relationships that students with attention-deficit/hyperactivity disorder (ADHD) have with their teachers, in mainstream inclusive primary, secondary and high school settings. Theoretical approaches and methodical choices were considered in understanding the literature and considering possible research areas. The methods used in the reviewed literature show that investigations in this research field have predominantly used quantitative surveys. Several theoretical approaches have been used, with attachment theory the most-prominent. The findings indicate students with ADHD generally feel less close to their teacher than do their non-ADHD peers, which agrees with the teachers’ perceptions. Thus, teachers experience less emotional closeness, less co-operation and more conflicts in their relations with their students with ADHD than with other students. Teachers’ rejection of ADHD students poses a risk factor for not only school failure, but also peer exclusion and rejection, leading to low self-esteem and loneliness.
The Demand for Commodity Insurance by Developing Country Agricultural Producers: Theory and an Application to Cocoa in Ghana

The author considers the benefit to agricultural producers of commodity price insurance that provides in every year-but in advance of the resolution of production and price uncertainty-a minimum price for a fixed or variable portion of production. Under the assumption that producers do not change their long term production and income diversification pattern, the author suggests a theoretical framework that leads to explicit formulas of the benefit in providing this type of insurance. He shows that this benefit depends not only on the actuarially fair insurance premium, but also on household-specific factors that depend on the attitudes to risk, the consumption smoothing parameters, and the household-specific exposures to income risks. The author applies the theoretical framework for Ghana, using the Ghana Living Standards Survey data to specify various classes of cocoa-producing households and monthly price data for both domestic and international prices, to formulate appropriate models for ascertaining price risks faced by producers. The author gives empirical estimates of the actuarially fair premium, and shows that they are smaller than market-based put option prices from organized exchanges. The overall benefit in providing minimum price insurance to households, however, turns out to be substantially higher than the actuarially fair premiums and the market-based put option prices. This is due to both the magnitude of the uncertainties facing the households, as well as their risk and consumption smoothing behavior.
Lactate Dehydrogenase-B Is Silenced by Promoter Methylation in a High Frequency of Human Breast Cancers

Objective Under normoxia, non-malignant cells rely on oxidative phosphorylation for their ATP production, whereas cancer cells rely on Glycolysis; a phenomenon known as the Warburg effect. We aimed to elucidate the mechanisms contributing to the Warburg effect in human breast cancer. Experimental design Lactate Dehydrogenase (LDH) isoenzymes were profiled using zymography. LDH-B subunit expression was assessed by reverse transcription PCR in cells, and by Immunohistochemistry in breast tissues. LDH-B promoter methylation was assessed by sequencing bisulfite modified DNA. Results Absent or decreased expression of LDH isoenzymes 1-4, were seen in T-47D and MCF7 cells. Absence of LDH-B mRNA was seen in T-47D cells, and its expression was restored following treatment with the demethylating agent 5'Azacytadine. LDH-B promoter methylation was identified in T-47D and MCF7 cells, and in 25/ 25 cases of breast cancer tissues, but not in 5/ 5 cases of normal breast tissues. Absent immuno-expression of LDH-B protein (<10% cells stained), was seen in 23/ 26 (88%) breast cancer cases, and in 4/8 cases of adjacent ductal carcinoma in situ lesions. Exposure of breast cancer cells to hypoxia (1% O2), for 48 hours resulted in significant increases in lactate levels in both MCF7 (14.0 fold, p = 0.002), and T-47D cells (2.9 fold, p = 0.009), but not in MDA-MB-436 (-0.9 fold, p = 0.229), or MCF10AT (1.2 fold, p = 0.09) cells. Conclusions Loss of LDH-B expression is an early and frequent event in human breast cancer occurring due to promoter methylation, and is likely to contribute to an enhanced glycolysis of cancer cells under hypoxia.
Custody and parenting time: Links to family relationships and well-being after divorce.

The father's role in child development typically undergoes profound change when the parents divorce. Around much of the world, this eventuality became about twice as likely in the past 40 years as it ever was previously in our history (Shiono & Quinn, 1994). Although divorce rates have decreased since the peak in 1979-1981 (Fine & Harvey, 2006), by the time they reach age 16, the percentage of children who are anticipated to live in a divorced home is between 31 % (Bumpass & Sweet, 1989) and 40% (Cherlin, 1992). Chapter 6 discusses many of the changes wrought by divorce in the father-child relationship. The goal of the current chapter, a new one for this series, is to survey what is known about how postdivorce parenting arrangements impact the family. In the past, these arrangements included determining which parent would be the child's custodial parent, and how much visitation would occur between the child and the other parent. There is now a widespread movement to abolish the terms custody and visitation, and replace them with the more neutral terms parenting plans, parenting time, and decision-making responsibility (Emery, 2004; Kelly, 2004, 2007). As of 2005,26 states had statutes addressing parenting plans (Douglas, 2006). In the European Union and the United Kingdom, the term parental responsibility predominates (Lowe, 2005), which both parents legally retain regardless of the residential order. In New Zealand, the 2004 Care of Children Act replaced the term custody with day-today care, and access or visitation with contact (Martindale-Hubbell Law Digest: New Zealand, 2008). Notwithstanding these attempts to reform nomenclature, many issues facing divorced families (e.g., determining child support, adjudicating relocation disputes, signing for a child's driver's license, taking the child out of the country) require designation of the parent with whom the child primarily lives or to whom the court grants legal decision-making authority. Thus, we
Is Dishonesty Contagious?

When an individual believes that peers are predominantly untruthful in a given situation, is he/she more likely to be untruthful in that situation? We study this question in deception experiments patterned after Gneezy [Gneezy U. “Deception: The Role of Consequences. ” American Economic Review, 95, 2005, 384–94] and conducted in Arizona, California, and India. We find evidence that dishonesty is indeed contagious.
A Simple and Accurate Syntax-Agnostic Neural Model for Dependency-based Semantic Role Labeling

We introduce a simple and accurate neural model for dependency-based semantic role labeling. Our model predicts predicate-argument dependencies relying on states of a bidirectional LSTM encoder. The semantic role labeler achieves competitive performance on English, even without any kind of syntactic information and only using local inference. However, when automatically predicted part-of-speech tags are provided as input, it substantially outperforms all previous local models and approaches the best reported results on the English CoNLL-2009 dataset. We also consider Chinese, Czech and Spanish where our approach also achieves competitive results. Syntactic parsers are unreliable on out-of-domain data, so standard (i.e., syntactically-informed) SRL models are hindered when tested in this setting. Our syntax-agnostic model appears more robust, resulting in the best reported results on standard out-of-domain test sets.
Housing market financialization, neoliberalism and everyday retrenchment of social housing

Social housing policy in Ireland has evolved over several decades into a significantly marketized tenure which relies on, supports and expands the private housing market. In this paper we argue that it does so in ways that contribute to the financialization of housing by embedding housing in volatile financial market cycles. Although the majority of the literature on financialization, both in Ireland and internationally, has tended to focus on home ownership and mortgage markets, we argue that the retrenchment of social housing and the shift towards subsidized private rental accommodation have been key features of the process of financialization and of Ireland’s experience of boom and bust. The neoliberal turn in social housing policy, however, did not take shape in the form of either a coherent ideological project or a coherent suite of policy measures, but rather through the kind of piecemeal, ad hoc and typically ‘pragmatic’ processes identified by Kitchin et al. It is by examining the unfolding of these ad hoc processes that we identify both the neoliberalization of social housing policy and the interfaces between this process and that of financialization, particularly by highlighting how the former has enabled and facilitated the latter.
The impact of institutionalization on child development

During the past 10 years researchers studying children adopted from Romanian orphanages have had the opportunity to revisit developmental questions regarding the impact of early deprivation on child development. In the present paper the effects of deprivation are examined by reviewing both the early and more recent literature on studies of children who spent the first few years of life in institutions. Special attention is given to the Canadian study of Romanian adoptees in which the author has been involved. Findings across time and studies are consistent in showing the negative impact of institutionalization on all aspects of children’s development (intellectual, physical, behavioral, and social–emotional). Results of studies show, however, that institutionalization, although a risk factor for less optimal development, does not doom a child to psychopathology. However, the impact of institutionalization is greater when coupled with risk factors in the postinstitutional environment. Methodological and conceptual difficulties in research with institutionalized samples of children are discussed and future directions for research are
Why are some languages confused for others? Investigating data from the Great Language Game

In this paper we explore the results of a large-scale online game called ‘the Great Language Game’, in which people listen to an audio speech sample and make a forced-choice guess about the identity of the language from 2 or more alternatives. The data include 15 million guesses from 400 audio recordings of 78 languages. We investigate which languages are confused for which in the game, and if this correlates with the similarities that linguists identify between languages. This includes shared lexical items, similar sound inventories and established historical relationships. Our findings are, as expected, that players are more likely to confuse two languages that are objectively more similar. We also investigate factors that may affect players’ ability to accurately select the target language, such as how many people speak the language, how often the language is mentioned in written materials and the economic power of the target language community. We see that non-linguistic factors affect players’ ability to accurately identify the target. For example, languages with wider ‘global reach’ are more often identified correctly. This suggests that both linguistic and cultural knowledge influence the perception and recognition of languages and their similarity.
‘Born this Way’? Prenatal Exposure to Testosterone May Determine Behavior in Competition and Conflict

It is documented that fetal exposure to sexual hormones has long lasting effects on human behavior. The second-to-fourth digit ratio (DR) is a putative marker for prenatal exposure to testosterone (compared to estrogens) while in uterus, with higher relative exposure to testosterone resulting in a lower DR. Although the existing literature documents the correlation of DR with various decisions, and testosterone has been related to competitive behaviors, little research has studied the effect of DR on competition in conflict situations where skills do not matter. We investigate this question in the laboratory. Based on a previously obtained large sample of student subjects, we selectively invite subjects to the laboratory if their right-hand DR is in the top (High type) or bottom (Low type) tercile for their gender. Unbeknownst to the subjects, we perform a controlled match of High and Low types as opponents in a 2-person Tullock contest. We find that Low type (higher exposure to testosterone) males expend significantly higher conflict effort than High type males, that is, they are more aggressive, which reduces their opponents’ earnings. Among females, however, everyone is more aggressive against the High type (who respond less aggressively). These results can partially be explained through high joy of winning and/or spitefulness for Low type males, and high spitefulness for Low type females. This investigation sheds light on the importance of biological aspects in the ex-ante determinants of conflict, and on contest design.
Strengthening the Next Generation: A Multi-faceted Program to Develop Leadership Capacity in Emerging Nonprofit Leaders

Nonprofits face a leadership crisis in the decade to come as senior leaders are expected to retire in record numbers and as emerging leaders fail to get the development they need to grow their skills. Identifying and preparing the next generation of leaders to develop themselves and eventually move into senior leadership roles is therefore important. In one United States community, this need is being met through the development of cohorts of emerging leaders participating in an 8-month leadership development program that includes distinctive features such as individual coaching, strong peer learning, involvement of exemplary senior leaders, and alumni engagement. This article shares the design and outcomes of the first four years of this initiative for other communities to customize and build upon to meet their own unique circumstances.
Income effect and altruism

We investigate the consequences of a pure income effect on the altruistic behavior of donors. Inequity aversion theories predict either no effect or a decrease in giving, whereas warm-glow theory predicts an increase in giving with an increase in the common income of donor and receiver. Theoretical predictions being contradictory, we run a dictator game in which we vary the common show-up fee of both the dictator and the recipient, but keep an extra amount to be shared the same. The prediction of the warm-glow theory is supported.
Management Influence on Auditor Selection and Subsequent Impairments of Auditor Independence During the Post-SOX Period

This study investigates the influence of management over auditor selection decisions during a period in which audit committees have “direct responsibility” for auditor selection. We find that contrary to the intent of SOX, management continues to have significant influence over auditor selection and this is not mitigated by the presence of an apparently higher quality audit committee. As SOX presumes that management influence over auditor selection leads to negative outcomes, we also examine the impact that management influence has on proxies for subsequent auditor independence during the post-SOX period. We find that companies whose managers influence auditor selection are significantly less likely to receive going concern opinions, but no evidence of an impact on earnings management. We also find mixed evidence as to whether the relationship between management influence over auditor selection and subsequent audit quality is influenced by audit committee quality.
The rad18 gene of Schizosaccharomyces pombe defines a new subgroup of the SMC superfamily involved in DNA repair

The rad18 mutant of Schizosaccharomyces pombe is very sensitive to killing by both UV and gamma radiation. We have cloned and sequenced the rad18 gene and isolated and sequenced its homolog from Saccharomyces cerevisiae, designated RHC18. The predicted Rad18 protein has all the structural properties characteristic of the SMC family of proteins, suggesting a motor function--the first implicated in DNA repair. Gene deletion shows that both rad18 and RHC18 are essential for proliferation. Genetic and biochemical analyses suggest that the product of the rad18 gene acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair. This second repair pathway involves the products of the rhp51 gene (the homolog of the RAD51 gene of S. cerevisiae) and the rad2 gene.
Emerging chronic non-communicable diseases in rural communities of Northern Ethiopia: evidence using population-based verbal autopsy method in Kilite Awlaelo surveillance site.

INTRODUCTION In countries where most deaths are outside health institutions and medical certification of death is absent, verbal autopsy (VA) method is used to estimate population level causes of death. METHODS VA data were collected by trained lay interviewers for 409 deaths in the surveillance site. Two physicians independently assigned cause of death using the International Classification of Diseases manual. RESULTS In general, infectious and parasitic diseases accounted for 35.9% of death, external causes 15.9%, diseases of the circulatory system 13.4% and perinatal causes 12.5% of total deaths. Mortalities attributed to maternal causes and malnutrition were low, 0.2 and 1.5%, respectively. Causes of death varied by age category. About 22.1, 12.6 and 8.4% of all deaths of under 5-year-old children were due to bacterial sepsis of the newborn, acute lower respiratory infections such as neonatal pneumonia and prematurity including respiratory distress, respectively. For 5-15-year-old children, accidental drowning and submersion, accounting for 34.4% of all deaths in this age category, and accidental fall, accounting for 18.8%, were leading causes of death. Among 15-49-year-old adults, HIV/AIDS (16.3%) and tuberculosis (12.8%) were commonest causes of death, whereas tuberculosis and cerebrovascular diseases were major killers of those aged 50 years and above. CONCLUSION In the rural district, mortality due to chronic non-communicable diseases was very high. The observed magnitude of death from chronic non-communicable disease is unlikely to be unique to this district. Thus, formulation of chronic disease prevention and control strategies is recommended.
Synthesis of interconnection networks: A novel approach

The interconnection network is a crucial element in parallel and distributed systems. Synthesizing networks that satisfy a set of desired properties, such as high reliability, low diameter and good scalability is a difficult problem to which there has been no completely satisfactory solution. In this paper, we present a new approach to network synthesis. We start by generating a large number of random regular networks. These networks are then passed through filters, which filter out networks that do not satisfy specified network design requirements. By applying multiple filters in tandem, it is possible to synthesize networks which satisfy a multitude of properties. The filtered output thus constitutes a short-list of "good" networks that the designer can choose from. The use of random regular networks was motivated by their surprisingly good performance with regard to almost all properties that characterize a good interconnection network. Experimental results have shown that this approach is practical and powerful. In this paper we focus on the generation of networks which have low diameter, good scalability and high fault tolerance. These generated networks are shown to compare favorably with several well-known networks.
Spatiotemporal Changes to the Subventricular Zone Stem Cell Pool through Aging

Through adulthood, the rodent subventricular zone (SVZ) stem cell niche generates new olfactory bulb interneurons. We had previously reported that the number of new neurons produced in the SVZ declines through aging; however, age-related changes attributable specifically to the SVZ neural stem cell (NSC) population have not been fully characterized. Here, we conducted a spatiotemporal evaluation of adult SVZ NSCs. We assessed ventricle-contacting NSCs, which together with ependymal cells form regenerative units (pinwheels) along the lateral wall of the lateral ventricle. Based on their apical GFAP-expressing process, individual NSCs were identified across the ventricle surface using serial reconstruction of the SVZ. We observed an 86% decline in total NSCs/mm2 of intact ependyma in 2-year old versus 3-month-old mice, with fewer NSC processes within each aged pinwheel. This resulted in an associated 78% decline in total pinwheel units/mm2. Regional analysis along the lateral ventricle surface revealed that the age-dependent decline of NSCs and pinwheels is spatially uniform and ultimately maintains the conserved ratio of olfactory bulb interneuron subtypes generated in young mice. However, the overall neurogenic output of the aged SVZ is reduced. Surprisingly, we found no significant change in the number of actively proliferating NSCs per mm2 of ventricle surface. Instead, our data reveal that, although the total NSC number, pinwheel units and NSCs per pinwheel decline with age, the percentage of actively, mitotic NSCs increases, indicating that age-related declines in SVZ-mediated olfactory bulb neurogenesis occur downstream of NSC proliferation.