Miracle-dz/UniFAR-FTUs huggingface dataset:
Brain Processes in Mothers and Nulliparous Women in Response to Cry in Different Situational Contexts: A Default Mode Network Study

SYNOPSIS Objective: In everyday life, parents must respond to and interact with children while in different situational contexts. How situational contexts influence parents’ responses has not been systematically studied. Here we investigated mothers’ versus nonmothers’ neural responses to infant vocalizations in different situations with different task demands. Design: Using fMRI in 21 women (10 mothers), we explored the effects of being distracted by self-oriented (self-referential decisions about personality adjectives) versus goal-oriented (syllabic counting of personality adjectives) tasks while listening to infant cry in comparison with other emotional sounds (infant laughing, adult crying) on the activity of two medial nodes of the Default Mode Network (DMN): the medial prefrontal cortex (MPFC) and posterior cingulate cortex (PCC). Results: In the self-oriented task while listening to infant cry, both mothers and nulliparas showed (weak) activation of the DMN; this response likely reflects a shift of attention from the task to the cry. In the goal-oriented task, mothers, not nulliparas, showed (weak) activation of the DMN; this result is compatible with interference of emotional sounds while attending to a goal-oriented task, an activity that deactivates the DMN. Conclusions: Mothers are prone to process infant cry and emotional sounds and are less distracted from doing so by situational contexts, demonstrating their greater sensitivity to emotional sounds such as cry. By contrast, situational context influenced brain responses to infant sounds in nulliparas.
XMM—Newton EPIC observations of Her X-1

We present spin-resolved X-ray data of the neutron star binary Her X-1 taken using the EPIC detectors on XMM‐Newton. The data were taken at three distinct epochs through the 35-d precession period. The energy-dependent light curves of this source vary significantly from epoch to epoch. It is known that the relative phasing of the soft (1 keV) and hard (2 keV) X-rays varies. Here, we find that the phase shift between the soft and hard bands during the main-on state is considerably different from that observed in the past. Further, it continues to change significantly during the other two observations. This suggests that we are observing, for the first time, a substantial and continuous variation in the tilt of the disc, as it is expected if the accretion disc is precessing in the system. Analysis of the spin resolved data confirms that the equivalent width variation of the fluorescence Fe K line at ∼6.4 keV follows that of the soft X-ray emission in the main-on state, thus suggesting a common origin for Fe K line and thermal component. The Fe K line is considerably broader when the source is brightest.
Counting Small Cliques in 3-uniform Hypergraphs

Many applications of Szemerédi's Regularity Lemma for graphs are based on the following counting result. If ${\mathcal G}$ is an $s$-partite graph with partition $V({\mathcal G}) =\bigcup_{i=1}^{s} V_i$, $\vert V_i\vert =m$ for all $i\in [s]$, and all pairs $(V_i, V_j)$, $1\leq i < j\leq s$, are $\epsilon$-regular of density $d$, then $\mathcal{G}$ contains $(1\pm f(\epsilon))d^{({s\atop 2})}m^s$ cliques $K_{s}$, provided $\epsilon<\epsilon(d)$, where $f(\epsilon)$ tends to 0 as $\epsilon$ tends to 0. Guided by the regularity lemma for 3-uniform hypergraphs established earlier by Frankl and Rödl, Nagle and Rödl proved a corresponding counting lemma. Their proof is rather technical, mostly due to the fact that the ‘quasi-random’ hypergraph arising after application of Frankl and Rödl's regularity lemma is ‘sparse’, and consequently difficult to handle. When the ‘quasi-random’ hypergraph is ‘dense’ Kohayakawa, Rödl and Skokan (J. Combin. Theory Ser. A 97 307–352) found a simpler proof of the counting lemma. Their result applies even to $k$-uniform hypergraphs for arbitrary $k$. While the Frankl–Rödl regularity lemma will not render the dense case, in this paper, for $k=3$, we are nevertheless able to reduce the harder, sparse case to the dense case. Namely, we prove that a ‘dense substructure’ randomly chosen from the ‘sparse $\delta$-regular structure’ is $\delta$-regular as well. This allows us to count the number of cliques (and other subhypergraphs) using the Kohayakawa–Rödl–Skokan result, and provides an alternative proof of the counting lemma in the sparse case. Since the counting lemma in the dense case applies to $k$-uniform hypergraphs for arbitrary $k$, there is a possibility that the approach of this paper can be adopted to the general case as well.
Loss of ATRX and DAXX expression identifies poor prognosis for smooth muscle tumours of uncertain malignant potential and early stage uterine leiomyosarcoma

Uterine smooth muscle tumours of uncertain malignant potential (STUMP) are diagnostically and clinically challenging. The alternative lengthening of telomeres (ALT) telomere maintenance mechanism is associated with poor survival in soft tissue leiomyosarcoma. Time to first recurrence and survival were known for 18 STUMP and 43 leiomyosarcomata (LMS). These were screened for ALT telomere maintenance by the presence of ALT‐associated PML bodies (APBs) and for changes associated with the ALT phenotype, namely aberrant p53 expression, isocitrate dehydrogenase 1 mutation (R132H substitution) expression, mutant ATRX (αthalassemia/mental retardation syndrome X‐linked) expression and mutant DAXX (death‐domain‐associated protein) expression by immunohistochemistry (IHC). Overexpression of p16INK4A was examined immunohistologically in a subset of cases. Many of the tumours associated with death or recurrence demonstrated APBs commensurate with ALT telomere maintenance. However, all uterine STUMP (4/4), and vaginal STUMP (2/2) patients, and almost all LMS patients (88.4%, 23/26, including 90% (9/10) of stage 1 LMS cases), who had died of disease or who had recurrent disease, displayed loss of ATRX or DAXX expression. Loss of ATRX or DAXX expression identified poor prognosis (95% CI 2.1 to 40.8, p < 0.003), in the LMS group. Thus, loss of ATRX or DAXX expression in uterine smooth muscle tumours identifies a clinically aggressive molecular subtype of early stage LMS and when histopathological features are problematic such as in STUMP. As ATRX and DAXX IHC is readily performed in diagnostic laboratories these are potentially useful for routine histopathological classification and management.
Missing-Tag Detection and Energy–Time Tradeoff in Large-Scale RFID Systems With Unreliable Channels

Radio frequency identification (RFID) technologies are poised to revolutionize retail, warehouse, and supply chain management. One of their interesting applications is to automatically detect missing tags in a large storage space, which may have to be performed frequently to catch any missing event such as theft in time. Because RFID systems typically work under low-rate channels, past research has focused on reducing execution time of a detection protocol to prevent excessively long protocol execution from interfering normal inventory operations. However, when active tags are used for a large spatial coverage, energy efficiency becomes critical in prolonging the lifetime of these battery-powered tags. Furthermore, much of the existing literature assumes that the channel between a reader and tags is reliable, which is not always true in reality because of noise/interference in the environment. Given these concerns, this paper makes three contributions. First, we propose a novel protocol design that considers both energy efficiency and time efficiency. It achieves multifold reduction in both energy cost and execution time when compared to the best existing work. Second, we reveal a fundamental energy-time tradeoff in missing-tag detection, which can be flexibly controlled through a couple of system parameters in order to achieve desirable performance. Third, we extend our protocol design to consider channel error under two different models. We find that energy/time cost will be higher in unreliable channel conditions, but the energy-time tradeoff relation persists.
The Rise of the Region State

THE NATION STATE has become an unnatural, even dysfunctional, unit for organizing human activ ity and managing economic endeavor in a borderless world. It represents no genuine, shared community of eco nomic interests; it defines no meaningful flows of economic activity. In fact, it overlooks the true linkages and synergies that exist among often disparate populations by combining important measures of human activity at the wrong level of analysis. For example, to think of Italy as a single economic entity ignores the reality of an industrial north and a rural south, each vastly different in its ability to contribute and in its need to receive. Treating Italy as a single economic unit forces one? as a private sector manager or a public sector official? to operate on the basis of false, implausible and nonexistent averages. Italy is a country with great disparities in industry and income across regions. On the global economic map the lines that now matter are those defining what may be called "region states. " The bound aries of the region state are not imposed by political fiat. They are drawn by the deft but invisible hand of the global market for goods and services. They follow, rather than precede, real flows of human activity, creating nothing new but ratifying existing patterns manifest in countless individual decisions. They represent no threat to the political borders of any nation, and they have no call on any taxpayer's money to finance military forces to defend such borders. Region states are natural economic zones. They may or may not fall within the geographic limits of a particular
Interstitial pulmonary disorders in indium-processing workers

The production of indium-tin oxide has increased, owing to the increased manufacture of liquid-crystal panels. It has been reported that interstitial pneumonia occurred in two indium-processing workers; therefore, the present study aimed to evaluate whether interstitial pulmonary disorders were prevalent among indium workers. The study was carried out in 108 male workers in the indium plant where the two interstitial pneumonia patients mentioned above were employed, and included high-resolution computed tomography (HRCT) of the lungs, pulmonary function tests and analysis of serum sialylated carbohydrate antigen KL-6 and the serum indium concentration. Significant interstitial changes were observed in 23 indium workers on HRCT and serum KL-6 was abnormally high (>500 U·mL-1) in 40 workers. Workers with serum indium concentrations in the highest quartile had significantly longer exposure periods, greater HRCT changes, lower diffusing capacity of the lung for carbon monoxide and higher KL-6 levels compared with those in the lowest quartile. The serum indium concentration was positively correlated with the KL-6 level and with the degree of HRCT changes. In conclusion, the results of the present study indicated that serum KL-6 and high-resolution computed tomography abnormalities were prevalent among indium workers and that these abnormalities increased with the indium burden, suggesting that inhaled indium could be a potential cause of occupational lung disease.
Behavioral Characterization of A53T Mice Reveals Early and Late Stage Deficits Related to Parkinson’s Disease

Parkinson's disease (PD) pathology is characterized by the formation of intra-neuronal inclusions called Lewy bodies, which are comprised of alpha-synuclein (α-syn). Duplication, triplication or genetic mutations in α-syn (A53T, A30P and E46K) are linked to autosomal dominant PD; thus implicating its role in the pathogenesis of PD. In both PD patients and mouse models, there is increasing evidence that neuronal dysfunction occurs before the accumulation of protein aggregates (i.e., α-syn) and neurodegeneration. Characterization of the timing and nature of symptomatic dysfunction is important for understanding the impact of α-syn on disease progression. Furthermore, this knowledge is essential for identifying pathways and molecular targets for therapeutic intervention. To this end, we examined various functional and morphological endpoints in the transgenic mouse model expressing the human A53T α-syn variant directed by the mouse prion promoter at specific ages relating to disease progression (2, 6 and 12 months of age). Our findings indicate A53T mice develop fine, sensorimotor, and synaptic deficits before the onset of age-related gross motor and cognitive dysfunction. Results from open field and rotarod tests show A53T mice develop age-dependent changes in locomotor activity and reduced anxiety-like behavior. Additionally, digigait analysis shows these mice develop an abnormal gait by 12 months of age. A53T mice also exhibit spatial memory deficits at 6 and 12 months, as demonstrated by Y-maze performance. In contrast to gross motor and cognitive changes, A53T mice display significant impairments in fine- and sensorimotor tasks such as grooming, nest building and acoustic startle as early as 1–2 months of age. These mice also show significant abnormalities in basal synaptic transmission, paired-pulse facilitation and long-term depression (LTD). Combined, these data indicate the A53T model exhibits early- and late-onset behavioral and synaptic impairments similar to PD patients and may provide useful endpoints for assessing novel therapeutic interventions for PD.
Five Shades of Noise: Analyzing Machine Translation Errors in User-Generated Text

It is widely accepted that translating usergenerated (UG) text is a difficult task for modern statistical machine translation (SMT) systems. The translation quality metrics typically used in the SMT literature reflect the overall quality of the system output but provide little insight into what exactly makes UG text translation difficult. This paper analyzes in detail the behavior of a state-of-the-art SMT system on five different types of informal text. The results help to demystify the poor SMT performance experienced by researchers who use SMT as an intermediate step of their UG-NLP pipeline, and to identify translation modeling aspects that the SMT community should more urgently address to improve translation of UG data.
Is Knowledge-Free Induction of Multiword Unit Dictionary Headwords a Solved Problem?

We seek a knowledge-free method for inducing multiword units from text corpora for use as machine-readable dictionary headwords. We provide two major evaluations of nine existing collocation-finders and illustrate the continuing need for improvement. We use Latent Semantic Analysis to make modest gains in performance, but we show the significant challenges encountered in trying this approach.
An Interdisciplinary Journal

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Modularity and Innovation in Complex Systems

The problem of designing, coordinating and managing complex systems is central to the management and organizations literature. Recent writings have emphasized the important role of modularity in enhancing the adaptability of such complex systems. However, little attention has been paid to the problem of identifying what constitutes an appropriate modularization of a complex system. We develop a formal simulation model that allows us to carefully examine the dynamics of innovation and performance in complex systems. The model points to the trade-off between the virtues of parallelism that modularity offers and the destabilizing effects of overly refined modularization. In addition, high levels of integration can lead to modest levels of search and a premature fixation on inferior designs. The model captures some key aspects of technological evolution as a joint process of autonomous firm level innovation and the interaction of systems and modules in the marketplace. We discuss the implications of these arg.
Potential Applicability of Recombinant Factor VIIa for Intracerebral Hemorrhage

Background and Purpose— To date, there are no proven, effective treatments for intracerebral hemorrhage (ICH) beyond supportive medical care. A recent randomized, blinded, placebo-controlled trial of recombinant factor VIIa (rFVIIa) administered intravenously within 4 hours of ICH onset reported a reduction in morbidity and mortality compared with placebo. We sought to determine the potential applicability of rFVIIa in a large, population-based cohort of ICH patients. Methods— All of the patients age ≥18 years hospitalized with nontraumatic ICH in the Greater Cincinnati region were identified from May 1998 to July 2001 and August 2002 to April 2003. Patient demographics were compared with the inclusion and exclusion criteria from the rFVIIa trial to determine eligibility for treatment and reasons for exclusion. Mortality in the eligible patient group was compared with the placebo group in the rFVIIa trial. Results— Over 4 calendar years, 1018 ICH patients were identified; of these, 133 (13.1%) had no exclusions and presented within the prescribed time window. An additional 45 patients (4.4%) may have been eligible but had uncertain onset or computed tomography scan times. The most common reasons for exclusion (not mutually exclusive) were late presentation (n=398), vaso-occlusive disease (n=369), deep coma (n=219), and prolonged international normalized ratio or partial thromboplastin time (n=200). Mortality at 90 days among potentially eligible patients was the same as for the placebo group in the rFVIIa trial (29% versus 29%; P=0.99). Conclusions— In this large, population-based ICH cohort, 13.1% to 17.5% of patients would have qualified for treatment with rFVIIa by trial criteria.
Diagnostic role of survivin in urinary bladder cancer.

BACKGROUND Early diagnosis of carcinoma of bladder remains a challenge. Survivin, a member of the inhibitor of apoptosis (IAP) protein family, is frequently activated in bladder carcinoma. The objective of this study was to investigate urinary survivin as a marker for diagnosis of urinary bladder. MATERIALS AND METHODS We examined urinary survivin concentration in 28 healthy individuals, 46 positive controls and 117 cases of histologically proven TCC prior to transurethral resection, using ELISA, and compared values with findings for urinary cytology. RESULTS Survivin was found to be significantly higher in the cancer group (P<0.05). A cut off value of 17.7 pg/ml was proposed, with an approximate sensitivity of 82.9% and specificity of 81.1% (P<0.0001), whereas urine cytology had a sensitivity of 66.7% and a specificity of 96.0%. CONCLUSIONS Urinary survivin can be used as a non-invasive diagnostic biomarker for TCC bladder, both for primary and recurrent disease.
A SYNCHRONIZATION CONTROL SCHEME FOR REAL-TIME STREAMING MULTIMEDIA APPLICATIONS

In this paper, we propose an adaptive synchronization control scheme to achieve both intra-stream and interstream synchronization for real-time streaming multimedia applications on the Internet. Based upon synchronization errors calculated in real-time, our scheme piecewisely adjusts the end-to-end delay to compensate for the delay variation. It does so by controlling the virtual clock implemented at the destination end. Simulation results show that our control scheme is able to maintain good synchronization performance under different network conditions.
An experiment on performance study of IEEE 802.15.4 wireless networks

IEEE 802.15. 4 is an emerging standard specifically designed for low-rate wireless personal area networks (LR-WPAN) with a focus on enabling the wireless sensor networks. It attempts to provide a low data rate, low power, and low cost wireless networking on the device-level communication. In this paper, we have established a realistic environment for the preliminary performance evaluation of the IEEE 802.15. 4 wireless networks. Several sets of practical experiments are conducted to study its various features, including the effects of I) the direct and indirect data transmissions, 2) CSMA-CA mechanism, 3) data payload size, and 4) beacon-enabled mode. The data throughput, delivery ratio, and received signal strength indication (RSSI) are investigated as the performance metrics
The 2005 and 2006 DANDELIONS NO2 and aerosol intercomparison campaigns

[1] Dutch Aerosol and Nitrogen Dioxide Experiments for Validation of OMI and SCIAMACHY (DANDELIONS) is a project that encompasses validation of spaceborne measurements of NO2 by the Ozone Monitoring Instrument (OMI) and Scanning Imaging Absorption Spectrometer for Atmospheric Cartography (SCIAMACHY), and of aerosol by OMI and Advanced Along-Track Scanning Radiometer (AATSR), using an extensive set of ground-based and balloon measurements over the polluted area of the Netherlands. We present an extensive data set of ground-based, balloon, and satellite data on NO2, aerosols, and ozone obtained from two campaigns within the project, held during May–June 2005 and September 2006. We have used these data for first validation of OMI NO2, and the data are available through the Aura Validation Data Center website for use in other validation efforts. In this paper we describe the available data, and the methods and instruments used, including the National Institute of Public Health and the Environment (RIVM) NO2 lidar. We show that NO2 from Multi-Axis Differential Optical Absorption Spectroscopy (MAX-DOAS) compares well with in situ measurements. We show that different MAX-DOAS instruments, operating simultaneously during the campaign, give very similar results. We also provide unique information on the spatial homogeneity and the vertical and temporal variability of NO2, showing that during a number of days, the NO2 columns derived from measurements in different directions varied significantly, which implies that, under polluted conditions, measurements in one single azimuth direction are not always representative for the averaged field that the satellite observes. In addition, we show that there is good agreement between tropospheric NO2 from OMI and MAX-DOAS, and also between total NO2 from OMI and direct-sun observations. Observations of the aerosol optical thickness (AOT) show that values derived with three ground-based instruments correspond well with each other, and with aerosol optical thicknesses observed by OMI.