Miracle-dz/UniFAR-FTUs huggingface dataset:
Bidimensionality and EPTAS

Bidimensionality theory appears to be a powerful framework for the development of meta-algorithmic techniques. It was introduced by Demaine et al. [J. ACM 2005] as a tool to obtain sub-exponential time parameterized algorithms for problems on H-minor free graphs. Demaine and Hajiaghayi [SODA 2005] extended the theory to obtain polynomial time approximation schemes (PTASs) for bidimensional problems, and subsequently improved these results to EPTASs. Fomin et. al [SODA 2010] established a third meta-algorithmic direction for bidimensionality theory by relating it to the existence of linear kernels for parameterized problems. In this paper we revisit bidimensionality theory from the perspective of approximation algorithms and redesign the framework for obtaining EPTASs to be more powerful, easier to apply and easier to understand. One of the important conditions required in the framework developed by Demaine and Hajiaghayi [SODA 2005] is that to obtain an EPTAS for a graph optimization problem Π, we have to know a constant-factor approximation algorithm for Π. Our approach eliminates this strong requirement, which makes it amenable to more problems. At the heart of our framework is a decomposition lemma which states that for "most" bidimensional problems, there is a polynomial time algorithm which given an H-minor-free graph G as input and an ∈ > 0 outputs a vertex set X of size ∈ · OPT such that the treewidth of G\X is O(1/∈). Here, OPT is the objective function value of the problem in question This allows us to obtain EPTASs on (apex)-minor-free graphs for all problems covered by the previous framework, as well as for a wide range of packing problems, partial covering problems and problems that are neither closed under taking minors, nor contractions. To the best of our knowledge for many of these problems including Cycle Packing, Vertex-H-Packing, Maximum Leaf Spanning Tree, and Partial r-Dominating Set no EPTASs on planar graphs were previously known.
An object-oriented design method for hypermedia information systems

The goal of our research has been to simplify the development of hypermedia information systems. Classical object-oriented methods are good at capturing the semantics of multimedia type hierarchies using inheritance and encapsulation. However, they are not good at describing the object interactions prevalent in hypermedia applications. Our approach has been to extend the model of an existing object-oriented method with a construct to explicitly capture object interactions. The result is an object-oriented method for the specification of hypermedia structures in information systems. <<ETX>>
Partial Purification of the Sec 13 – 31 Complex from Rat Liver Cytosol

Cargo is selectively exported from the ER in COPII vesicles. To analyze the role of COPII in selective transport from the ER, we have purified components of the mammalian COPII complex from rat liver cytosol and then analyzed their role in cargo selection and ER export. The purified mammalian Sec23–24 complex is composed of an 85-kD (Sec23) protein and a 120-kD (Sec24) protein. Although the Sec23–24 complex or the monomeric Sec23 subunit were found to be the minimal cytosolic components recruited to membranes after the activation of Sar1, the addition of the mammalian Sec13–31 complex is required to complete budding. To define possible protein interactions between cargo and coat components, we recruited either glutathione-S-transferase (GST)–tagged Sar1 or GST– Sec23 to ER microsomes. Subsequently, we solubilized and reisolated the tagged subunits using glutathioneSepharose beads to probe for interactions with cargo. We find that activated Sar1 in combination with either Sec23 or the Sec23–24 complex is necessary and sufficient to recover with high efficiency the type 1 transmembrane cargo protein vesicular stomatitis virus glycoprotein in a detergent-soluble prebudding protein complex that excludes ER resident proteins. Supplementing these minimal cargo recruitment conditions with the mammalian Sec13–31 complex leads to export of the selected cargo into COPII vesicles. The ability of cargo to interact with a partial COPII coat demonstrates that these proteins initiate cargo sorting on the ER membrane before budding and establishes the role of GTPase-dependent coat recruitment in cargo selec-
Evaluation of performance validity using a Rey Auditory Verbal Learning Test forced-choice trial

Abstract Objective: Forced-choice (FC) recognition memory is a common performance validity assessment methodology. This study introduces and evaluates the classification accuracy of a FC recognition trial for the Rey Auditory Verbal Learning Test (RAVLT). Method: The present sample of 122 military veterans (Mean age = 35.4, SD = 9.3) were all administered the RAVLT along with the FC procedure as part of a full neuropsychological protocol. Veterans were assigned to valid (n = 94) or invalid (n = 28) groups based on outcomes of performance validity measures. Results: The FC procedure was found to have strong sensitivity (67.9%) and specificity (92.6%) in predicting validity group status based on a cutoff score of ≤ 13. The FC trial outperformed RAVLT recognition hits (sensitivity = 46.4%, specificity = 91.5%) as a predictor of invalid performance. Conclusions: The RAVLT FC is demonstrated to be an effective measure of performance validity and is recommended for use as an adjunctive trial for the RAVLT.
The predictive validity of subjective adherence measures in patients with schizophrenia

Despite frequent use of subjective adherence measures in patients with schizophrenia as well as other chronic conditions, there are several reports that question the validity of these instruments. Three well known, representative subjective measures are the Medication Adherence Questionnaire (MAQ), the Drug Attitude Inventory (DAI), and the Compliance Rating Scale (CRS). In this study we explored the predictive validity of these instruments in a European sample of 119 stabilized outpatients with schizophrenia. Clinical outcome variables were relapse and admission to a psychiatric hospital during a follow‐up period of 12 months. Results indicate that the predictive validity of all three measures was poor. The MAQ was the least problematic predictor for relapse (Nagelkerke R2 = 0.09), and time to relapse (R2 = 0.07) and had the best sensitivity for relapse (63.6%) as well as admission (87.5%). The MAQ and CRS were both moderate predictive for admission (Nagelkerke R2 = 0.21, and R2 = 0.29). We conclude that the validity of the instruments studied here is questionable and have limited clinical relevance. Given the feasibility and ease of most subjective instruments, researchers may be tempted to use them but should be aware of the serious drawbacks of these instruments. Copyright © 2011 John Wiley & Sons, Ltd.
Embolization of portosystemic shunts for treatment of medically refractory hepatic encephalopathy

Treatment options for refractory hepatic encephalopathy (HE) are limited. Patients who fail medical management may harbor large portosystemic shunts (PSSs) which are possible therapeutic targets. This study aims to describe patient selection, effectiveness, and safety of percutaneous PSS embolization in those with medically refractory HE. A retrospective evaluation of consecutive adult patients with medically refractory HE referred for PSS embolization at a tertiary center was performed (2003‐2015). Patient data collected included the type of HE, medications, Model for End‐Stage Liver Disease (MELD) score, shunt type, embolization approach, and materials used. Outcomes of interest were immediate (7 days), intermediate (1‐4 months), and longer‐term (6‐12 months) effectiveness and periprocedural safety. Effectiveness was determined based on changes in hospitalization frequency, HE medications, and symptoms. Twenty‐five patients with large PSS were evaluated for shunt embolization. Five were excluded due to high MELD scores (n = 1), comorbid conditions (n = 1), or technical considerations (n = 3). Of 20 patients who underwent embolization, 13 had persistent and 7 had recurrent HE; 100% (20/20) achieved immediate improvement. Durable benefit was achieved in 100% (18/18) and 92% (11/12) at 1‐4 and 6‐12 months, respectively. The majority (67%; 8/12) were free from HE‐related hospitalizations over 1 year; 10% developed procedural complications, and all resolved. Six developed new or worsening ascites. In conclusion, PSS embolization is a safe and effective treatment strategy that should be considered for select patients with medically refractory HE. Liver Transplantation 22 723–731 2016 AASLD.
Analysis of Coxiela burnetti dihydrofolate reductase via in silico docking with inhibitors and molecular dynamics simulation

Coxiella burnetii is a gram-negative bacterium able to infect several eukaryotic cells, mainly monocytes and macrophages. It is found widely in nature with ticks, birds, and mammals as major hosts. C. burnetii is also the biological warfare agent that causes Q fever, a disease that has no vaccine or proven chemotherapy available. Considering the current geopolitical context, this fact reinforces the need for discovering new treatments and molecular targets for drug design against C. burnetii. Among the main molecular targets against bacterial diseases reported, the enzyme dihydrofolate reductase (DHFR) has been investigated for several infectious diseases. In the present work, we applied molecular modeling techniques to evaluate the interactions of known DHFR inhibitors in the active sites of human and C. burnetii DHFR (HssDHFR and CbDHFR) in order to investigate their potential as selective inhibitors of CbDHFR. Results showed that most of the ligands studied compete for the binding site of the substrate more effectively than the reference drug trimethoprim. Also the most promising compounds were proposed as leads for the drug design of potential CbDHFR inhibitors.
Quick response in fashion supply chains with retailers having boundedly rational managers

In fashion retailing, inventory decisions are usually made by a human manager who is not necessarily perfectly rational. In this situation, the inventory decisions made may not always be optimal. At the same time, with advances in technology, fashion retailers have access to the latest market information and can implement the quick response (QR) system that is very helpful to systematically deal with market disruptions. In this paper, we explore the value of QR with the consideration of a boundedly rational human manager in the fashion retailing company. We show that for both cases, with and without QR, the human retail manager's level of bounded rationality significantly hurts the expected profits of the retailer and supply chain, but it does not hurt the manufacturer's expected profit. In addition, for both cases, with and without QR, we indicate how a minimum ordering quantity (MOQ) measure can be imposed by the manufacturer on the retailer, so that the manufacturer can benefit (in terms of expected profit) from the retailer's bounded rationality behavior. We further prove that if the manufacturer sets the MOQ to be the same as the retailer's theoretical optimal ordering quantity, the manufacturer will enjoy a higher profit with 50% chance, if the retailer is boundedly rational.
Color responses of the human lateral geniculate nucleus: selective amplification of S-cone signals between the lateral geniculate nucleno and primary visual cortex measured with high-field fMRI

The lateral geniculate nucleus (LGN) is the primary thalamic nucleus that relays visual information from the retina to the primary visual cortex (V1) and has been extensively studied in non‐human primates. A key feature of the LGN is the segregation of retinal inputs into different cellular layers characterized by their differential responses to red‐green (RG) color (L/M opponent), blue‐yellow (BY) color (S‐cone opponent) and achromatic (Ach) contrast. In this study we use high‐field functional magnetic resonance imaging (4 tesla, 3.6 × 3.6 × 3 mm3) to record simultaneously the responses of the human LGN and V1 to chromatic and Ach contrast to investigate the LGN responses to color, and how these are modified as information transfers between LGN and cortex. We find that the LGN has a robust response to RG color contrast, equal to or greater than the Ach response, but a significantly poorer sensitivity to BY contrast. In V1 at low temporal rates (2 Hz), however, the sensitivity of the BY color pathway is selectively enhanced, rising in relation to the RG and Ach responses. We find that this effect generalizes across different stimulus contrasts and spatial stimuli (1‐d and 2‐d patterns), but is selective for temporal frequency, as it is not found for stimuli at 8 Hz. While the mechanism of this cortical enhancement of BY color vision and its dynamic component is unknown, its role may be to compensate for a weak BY signal originating from the sparse distribution of neurons in the retina and LGN.
A study of novel multifilament spreading and feeding method, to produce filament wrapped-staple core composite yarn using modified ring frame

Abstract In the area of filament wrapped-staple core composite yarn production, there are potential challenges in achieving better cover and hairiness among other mechanical properties. In a bid to further improve the wrapped-core yarn production; multifilament web spreading and feeding approaches were studied in relation to yarn properties. Multifilament spreading apparatus designed and used for our previous research work was further improved in order to increase spread width, minimize damage to monofilaments and control the spreading evenness. Uniform and increased multifilament spread width can be achieved by an elliptical shaped micro-grooved roller, overcoming roller surface imperfections, minimizing spreading assembly oscillations, and consequently achieve superior filament wrapping around the staple core. Filament-staple feeding arrangement might positively influence the multifilament wrapping-ability. Scanning electron microscopy was used to study effects of spreading on the surface of monofilament and micro-grooved rollers as well as related influence on composite yarn properties. Two kinds of 48Tex (12 Ne) composite yarns made on the modified frame, were compared to similar yarn produced using conventional ring frame. Results revealed that composite yarns produced by the modified method possess improved cover-ability as well as other properties compared to both previously reported and the traditional spinning methods.
Processing speed test: Validation of a self-administered, iPad®-based tool for screening cognitive dysfunction in a clinic setting

Background: Cognitive dysfunction is common in multiple sclerosis (MS) patients and has important consequences for daily activities, yet, unlike motor function, is not routinely assessed in the clinic setting. We developed the Processing Speed Test (PST), a self-administered iPad®-based tool to measure MS-related deficits in processing speed. Objective: To determine whether the PST is valid for screening cognitive dysfunction by comparing it to the paper-and-pencil Symbol Digit Modalities Test (SDMT). Methods: We assessed PST test–retest reliability, sensitivity of PST and SDMT in discriminating MS patients from healthy controls (HC), convergent validity between PST and SDMT, correlations between T2 lesion load and PST and SDMT, and PST performance with and without technician present during administration. Results: PST had excellent test–retest reliability, was highly correlated with SDMT, was slightly more sensitive than SDMT in discriminating MS from HC groups, and correlated better with cerebral T2 lesion load than did SDMT. Finally, PST performance was no different with or without a technician in the testing environment. Conclusion: PST has advantages over SDMT because of its efficient administration, scoring, and potential for medical record or research database integration. PST is a practical tool for routine screening of processing speed deficits in the MS clinic.
Expression of UDP-N-acetyl-D-galactosamine: Polypeptide N-acetylgalactosaminyltransferase-6 in Gastric Mucosa, Intestinal Metaplasia, and Gastric Carcinoma

Aberrant mucin O-glycosylation is often observed in cancer and is characterized by the expression of immature simple mucin-type carbohydrate antigens. UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-6 (ppGalNAc-T6) is one of the enzymes responsible for the initial step in O-glycosylation. This study evaluated the expression of ppGalNAc-T6 in human gastric mucosa, intestinal metaplasia, and gastric carcinomas. Our results showed that ppGalNAc-T6 is expressed in normal gastric mucosa and in intestinal metaplasia. A heterogeneous expression and staining pattern for this enzyme was observed in gastric carcinomas. ppGalNAc-T6 was expressed in 79% of the cases, and its expression level was associated with the presence of venous invasion. Our results provide evidence that ppGalNAc-T6 is an IHC marker associated with venous invasion in gastric carcinoma and may contribute to the understanding of the molecular mechanisms that underlie aberrant glycosylation in gastric carcinogenesis and in gastric carcinoma.
High Resolution Solar Physics by Interferometry: SOLARNET

We propose a mission concept allowing very high resolution in the far ultraviolet and ultraviolet, yet not compromising temporal and spectral resolutions. The compact interferometer system proposed for SOLARNET is capable of instantaneous imaging through three cophased telescopes of 35 cm diameter on a one meter baseline feeding a subtractive double monochromator providing wide field of view and high spectral resolution. Comprehensive mechanical and optical realization schemes and image reconstruction scenario have been developed and are presented. One of the major issue, the validity of the use of interferometric techniques (recombination principles, cophasing possibilities), was demonstrated both on a laboratory representative breadboard and directly on the Sun: feasibility of the cophasing of two telescopes on extended reference objects. Furthermore, a complete three telescopes imaging breadboard is now under realization and will be tested in laboratory this summer and on the sky this autumn. These progresses in both the modelisation and laboratory demonstration work truly open the possibility to use and discover from solar interferometers in Space in the short term, i.e. in the ESA F2/F3 framework. With a 1 meter baseline or so, a UV imaging interferometer like SOLARNET will reach a spatial resolution of 0.02" (20 km in the far UV) and a field-of-view of 40" allowing to untangle the confining and dissipating mechanisms and processes from the chromosphere to the corona (the spatial resolution is 40 times that of any previous experiments in Space). This "small" interferometer will also provide the first complete test of interferometric technologies in Space before investing in Ñ much Ñ larger Astrophysics or Earth Observation missions.
ORIGINAL ARTICLE: Dysregulation of plasma ghrelin in alcoholic cirrhosis

Objective Abnormalities in circulating ghrelin have been reported in chronic liver disease. This study assessed the response of anabolic peptides ghrelin, growth hormone (GH) and insulin‐like growth factor 1 (IGF‐1) in patients with alcoholic cirrhosis and healthy subjects to oral glucose. In a previous study, using oral glucose we identified loss of ghrelin regulation in nonalcoholic steato‐hepatitis.
A Simple and Selective Fluorescent Sensor Chip for Indole-3-Butyric Acid in Mung Bean Sprouts Based on Molecularly Imprinted Polymer Coatings

In this paper, we report the preparation of molecularly imprinted polymer coatings on quartz chips for selective solid-phase microextraction and fluorescence sensing of the auxin, indole-3-butyric acid. The multiple copolymerization method was used to prepare polymer coatings on silylated quartz chips. The polymer preparation conditions (e.g., the solvent, monomer, and cross-linker) were investigated systemically to enhance the binding performance of the imprinted coatings. Direct solid-phase fluorescence measurements on the chips facilitated monitoring changes in coating performance. The average binding capacity of an imprinted polymer coated chip was approximately 152.9 µg, which was higher than that of a non-imprinted polymer coated chip (60.8 µg); the imprinted coatings showed the highest binding to IBA among the structural analogues, indicating that the coatings possess high selectivity toward the template molecule. The developed method was used for the determination of the auxin in mung bean extraction, and the recovery was found to be in the range of 91.5% to 97.5%, with an RSD (n = 3) of less than 7.4%. Thus, the present study provides a simple method for fabricating a fluorescent sensor chip for selective analysis.
Loss of interneuron LTD and attenuated pyramidal cell LTP in Trpv1 and Trpv3 KO mice

TRPV (transient receptor potential, vanilloid) channels are a family of nonselective cation channels that are activated by a wide variety of chemical and physical stimuli. TRPV1 channels are highly expressed in sensory neurons in the peripheral nervous system. However, a number of studies have also reported TRPV channels in the brain, though their functions are less well understood. In the hippocampus, the TRPV1 channel is a novel mediator of long‐term depression (LTD) at excitatory synapses on interneurons. Here we tested the role of other TRPV channels in hippocampal synaptic plasticity, using hippocampal slices from Trpv1, Trpv3 and Trpv4 knockout (KO) mice. LTD at excitatory synapses on s. radiatum hippocampal interneurons was attenuated in slices from Trpv3 KO mice (as well as in Trpv1 KO mice as previously reported), but not in slices from Trpv4 KO mice. A previous study found that in hippocampal area CA1, slices from Trpv1 KO mice have reduced tetanus‐induced long‐term potentiation (LTP) following high‐frequency stimulation; here we confirmed this and found a similar reduction in Trpv3 KO mice. We hypothesized that the loss of LTD at the excitatory synapses on local inhibitory interneurons caused the attenuated LTP in the mutants. Consistent with this idea, blocking GABAergic inhibition rescued LTP in slices from Trpv1 KO and Trpv3 KO mice. Our findings suggest a novel role for TRPV3 channels in synaptic plasticity and provide a possible mechanism by which TRPV1 and TRPV3 channels modulate hippocampal output. © 2013 Wiley Periodicals, Inc.
Effect of Delay on the Boundary of the Basin of Attraction in a Self-Excited Single Graded-Response Neuron

Little attention has been paid in the past to the effects of interunit transmission delays (representing a xonal and synaptic delays) ontheboundary of the basin of attraction of stable equilibrium points in neural networks. As a first step toward a better understanding of the influence of delay, we study the dynamics of a single graded-response neuron with a delayed excitatory self-connection. The behavior of this system is representative of that of a family of networks composed of graded-response neurons in which most trajectories converge to stable equilibrium points for any delay value. It is shown that changing the delay modifies the location of the boundary of the basin of attraction of the stable equilibrium points without affecting the stability of the equilibria. The dynamics of trajectories on the boundary are also delay dependent and influence the transient regime of trajectories within the adjacent basins. Our results suggest that when dealing with networks with delay, it is important to study not only the effect of the delay on the asymptotic convergence of the system but also on the boundary of the basins of attraction of the equilibria.