Miracle-dz/UniFAR-FTUs huggingface dataset:
Dissociative identity disorder and ambivalence

While many theorists have argued that dissociative identity disorder (DID) is a case of multiple selves or persons in a single body, I maintain that DID instead should be understood as involving a single self who suffers from significant disruptions to self-consciousness. Evidence of overlapping abilities and memories, as well as the very logic of dissociation, supports the claim that DID results from internal conflict endured by a single self. Along these lines, I will maintain that alter-formation should be understood as the result of extreme emotional ambivalence. While it is true that subjects with DID exhibit volitional conflict, as Frankfurt [1988. The Importance of What We Care About. New York: Cambridge University Press; 1999. Necessity, Volition, and Love. New York: Cambridge University Press] maintains, I argue that these incompatible volitions have a deeper source: conflicting desires and affective stances concerning basic emotional needs that are not easily abandoned. A single subject turns to different alter-personalities as a way to cope with pervasive inner conflict while at the same time hiding contradictory impulses from herself.
“ Ideal Parent ” Structure Learning for Continuous Variable Bayesian Networks

Bayesian networks in general, and continuous variable networks in particular, have become increasingly popular in recent years, largely due to advances in methods that facilitate automatic learning from data. Yet, despite these advances, the key task of learning the structure of such models remains a computationally intensive procedure, which limits most applications to parameter learning. This problem is even more acute when learning networks in the presence of missing values or hidden variables, a scenario that is part of many real-life problems. In this work we present a general method for speeding structure search for continuous variable networks with common parametric distributions. We efficiently evaluate the approximate merit of candidate structure modifications and apply time consuming (exact) computations only to the most promising ones, thereby achieving significant improvement in the running time of the search algorithm. Our method also naturally and efficiently facilitates the addition of useful new hidden variables into the network structure, a task that is typically considered both conceptually difficult and computationally prohibitive. We demonstrate our method on synthetic and real-life data sets, both for learning structure on fully and partially observable data, and for introducing new hidden variables during structure search.
THERAPY OF ENDOCRINE DISEASE: Perspectives on the management of adrenal insufficiency: clinical insights from across Europe

Background Conventional glucocorticoid (GC) replacement for patients with adrenal insufficiency (AI) is inadequate. Patients with AI continue to have increased mortality and morbidity and compromised quality of life despite treatment and monitoring. Objectives i) To review current management of AI and the unmet medical need based on literature and treatment experience and ii) to offer practical advice for managing AI in specific clinical situations. Methods The review considers the most urgent questions endocrinologists face in managing AI and presents generalised patient cases with suggested strategies for treatment. Results Optimisation and individualisation of GC replacement remain a challenge because available therapies do not mimic physiological cortisol patterns. While increased mortality and morbidity appear related to inadequate GC replacement, there are no objective measures to guide dose selection and optimisation. Physicians must rely on experience to recognise the clinical signs, which are not unique to AI, of inadequate treatment. The increased demand for corticosteroids during periods of stress can result in a life-threatening adrenal crisis (AC) in a patient with AI. Education is paramount for patients and their caregivers to anticipate, recognise and provide proper early treatment to prevent or reduce the occurrence of ACs. Conclusions This review highlights and offers suggestions to address the challenges endocrinologists encounter in treating patients with AI. New preparations are being developed to better mimic normal physiological cortisol levels with convenient, once-daily dosing which may improve treatment outcomes.
Digital skills as a conditioning factor for digital political participation

Abstract While all forms of Internet activity have an impact on the lives of Internet users, some are particularly beneficial and allow people to improve their daily lives. One of such Internet use is Digital Political Participation (DDP). In this paper we seek to understand how the influence of digital skills on the adoption of Digital Political Participation practices may form the basis of a second level of digital divide and of a set of political inequalities. We operationalize the digital skills construct in terms of users’ Internet competence and level of appropriation. We hypothesize that digital skills have a significant influence on the adoption of beneficial uses of the Internet, such as DPP. At the same time, we examine whether digital skill levels are stratified by socio-demographic background, thereby generating political and social inequality. By looking at the Spanish case, we first tested the adequateness of the items chosen to measure these two dimensions. Second, we looked into sequences of multiple influences between socio-demographic variables and digital skills and between digital skills and DPP. The results show that socio demographic variables have an influence on digital skills. At the same time, digital skills have a strong influence on DPP.
Predominant influence of MGMT methylation in non-resectable glioblastoma after radiotherapy plus temozolomide

Background Patients with non-resectable glioblastoma generally exhibit a poor prognosis, even after radiotherapy plus concomitant and adjuvant temozolomide (XRT/TMZ→TMZ). Unfortunately, no data are available concerning the predictive value of O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation for this important subpopulation. For clarification, a prospective study was conducted. Methods Adult patients with a non-resectable glioblastoma were included. A molecular stereotactic biopsy technique was used for tumour characterisation combining histopathological diagnosis with small sample size adjusted methylation-specific PCR (MSP) and sodium bisulfite sequencing. Treatment included XRT (60 Gy in 30 fractions)/TMZ (daily dose of 75 mg/m2)→TMZ (150–200 mg/m2 per day for 5 days of every28-day cycle). The primary end point was progression-free survival (PFS). Secondary endpoints were overall survival (OS) and treatment response (TR). Patients were categorised in the Radiation Therapy Oncology Group (RTOG)-recursive partitioning analysis (RPA) Classes III (N=4), IV (N=12), V (N=28) and VI (N=12). Results and discussion The success rates of MSP and sequence analyses were 100%. The MGMT promoter was methylated in 30/56 tumours, which was associated with an increased PFS (median 56 versus 20 weeks; hazard ratio 0.15; range 0.07 to 0.33; p<0.0001), higher frequency of TR (93.3% vs 46.2%; p=0.0008) and increased OS (median 104 vs 28 weeks; hazard ratio 0.18; range 0.08 to 0.38; p<0.0001). The transient perioperative morbidity was 1.8%. Conclusion MGMT promoter methylation has a predominant favourable influence even for the important subpopulation with non-resectable glioblastoma. The molecular stereotactic biopsy technique is safe and effective for predictive evaluation and helps to avoid both over- and undertreatment.
Splenic Immune Response Is Down-Regulated in C57BL/6J Mice Fed Eicosapentaenoic Acid and Docosahexaenoic Acid Enriched High Fat Diet

Dietary n-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are associated with reduction of inflammation, although the mechanisms are poorly understood, especially how the spleen, as a secondary lymphoid organ, is involved. To investigate the effects of EPA and DHA on spleen gene expression, male C57BL/6J mice were fed high fat diets (HFD) differing in fatty acid composition, either based on corn oil (HFD-CO), or CO enriched with 2 g/100 g EPA and DHA (HFD-ED), for eight weeks. Spleen tissue was analyzed using transcriptomics and for fatty acids profiling. Biological processes (BPs) related to the immune response, including T-cell receptor signaling pathway, T-cell differentiation and co-stimulation, myeloid dendritic cell differentiation, antigen presentation and processing, and the toll like receptor pathway were downregulated by HFD-ED compared with control and HFD-CO. These findings were supported by the down-regulation of NF-κB in HFD-ED compared with HFD-CO fed mice. Lower phospholipid arachidonic acid levels in HFD-ED compared with HFD-CO, and control mice suggest attenuation of pathways via prostaglandins and leukotrienes. The HFD-ED also upregulated BPs related to erythropoiesis and hematopoiesis compared with control and HFD-CO fed mice. Our findings suggest that EPA and DHA down-regulate the splenic immune response induced by HFD-CO, supporting earlier work that the spleen is a target organ for the anti-inflammatory effects of these n-3 fatty acids.
Problematic Code Clones Identification Using Multiple Detection Results

Most code clones are generated by copy-and paste programming. Copy-and-paste programming shortens a time required for implementation because pasted code is a template of the required functionality. However, it sometimes brings on new bugs to the source code. After copy-and-paste, pasted code is somewhat changed fitting for the context of the region surrounding the pasted code. For example, some identifiers are replaced with other identifiers or a few statements are inserted, deleted, or changed. If such modifications are incorrectly performed, bugs occur in code clones. However, not all code clones are problematic, many code clones have decent reasons for their existence. Consequently, simple code clone detection is inefficient for identifying problematic code clones. Firstly, this paper proposes a classification scheme for dividing problematic code clones from non problematic ones. Secondly, it proposes a method for extracting specific code clones classified as problematic ones. Thirdly, it presents results of case studies conducted for evaluating the proposed method. The proposed method uses multiple code clone detection tools, and it doesn't directly analyze program source code. After multiple detections, simple operations are performed to extract code clones that are likely to be problematic. In the case studies conducted on an open source software system, the proposed method could actually identify 22 problematic code clones.
The Effects of Influenza Vaccination of Health Care Workers in Nursing Homes: Insights from a Mathematical Model

Background Annual influenza vaccination of institutional health care workers (HCWs) is advised in most Western countries, but adherence to this recommendation is generally low. Although protective effects of this intervention for nursing home patients have been demonstrated in some clinical trials, the exact relationship between increased vaccine uptake among HCWs and protection of patients remains unknown owing to variations between study designs, settings, intensity of influenza seasons, and failure to control all effect modifiers. Therefore, we use a mathematical model to estimate the effects of HCW vaccination in different scenarios and to identify a herd immunity threshold in a nursing home department. Methods and Findings We use a stochastic individual-based model with discrete time intervals to simulate influenza virus transmission in a 30-bed long-term care nursing home department. We simulate different levels of HCW vaccine uptake and study the effect on influenza virus attack rates among patients for different institutional and seasonal scenarios. Our model reveals a robust linear relationship between the number of HCWs vaccinated and the expected number of influenza virus infections among patients. In a realistic scenario, approximately 60% of influenza virus infections among patients can be prevented when the HCW vaccination rate increases from 0 to 1. A threshold for herd immunity is not detected. Due to stochastic variations, the differences in patient attack rates between departments are high and large outbreaks can occur for every level of HCW vaccine uptake. Conclusions The absence of herd immunity in nursing homes implies that vaccination of every additional HCW protects an additional fraction of patients. Because of large stochastic variations, results of small-sized clinical trials on the effects of HCW vaccination should be interpreted with great care. Moreover, the large variations in attack rates should be taken into account when designing future studies.
Investigation of the unsteady Edney type IV and VII shock-shock interaction

Edney type IV and type VII shock-shock interactions are complex hypersonic flow phenomena. They are characterized by a supersonic jet which reaches far into the flow field. An experimental investigation of the inner jet structure is difficult, especially in cases where the jet is subject to high-frequency unsteady movements. The present paper provides insight into the jet structure by means of a highly-resolved Computational Fluid Dynamics analysis in thermochemical nonequilibrium. Simulations of an Edney type IV interaction in nitrogen flow are presented. Multiple resolution levels support the identification and analysis of the mechanisms of the jet unsteadiness. The second configuration is an Edney type VII interaction. This shock-shock interaction type was observed and defined in nitrogen flow by Yamamoto et al. The present results demonstrate that this interaction may also be observed in CO2-dominated flow with a gas composition similar to the Martian atmosphere. The results provide insight into the jet structure of this less known interaction.
Warranty Reserve: Contingent Liability, Strategic Signal, or Earnings Management Tool?*

Utilizing a database that recently became available due to the requirements of FIN 45, we examine the information content of accounting disclosures on warranties from two perspectives. First, since a warranty policy is a business strategy through which firms choose to promote their products, a warranty reserve may serve two roles: a signal of product quality as well as a contingent liability to be honored in the future. Consistent with this view, we find that the stock market recognizes the warranty reserve as both a signal of firms’ future performance as well as a liability. Second, since warranty accruals require estimation of future claims, any discretion in this context can also be used as a tool of earnings management. Consistent with this expectation, our evidence indicates that managers use warranty accruals to manage earnings opportunistically to meet their earnings targets.
Social Workers' Perceptions of Training Preparedness and Social Justice Norms on Workplace Empowerment

ABSTRACT This study examined the relationship between (a) social workers' perceptions of preparedness to perform in their professional roles and perceived social justice behaviors at work and (b) workers' sense of workplace empowerment. A sample of 152 currently licensed social workers responded to web or mailed surveys. Respondents were more likely to perceive having workplace empowerment related to meaning in their work if they reported their social work program training prepared them for their professional roles. Perceived social justice behaviors at work were associated with workers' experiencing empowerment related to the impact they had at work. Social workers' sense of training preparedness and experiencing social justice at work can positively influence workers' perceived empowerment. Enforcing the importance of engaging in social justice with clients in social work education, both in class and in field placements, has the potential for long-lasting effects on empowerment in students' future workplaces. Agency-level management should ensure continuity in social justice activities to enhance feelings of workplace empowerment, which may help social workers connect with clients. Future research should examine elements of social work programs that promote feelings of empowerment in order to understand how the same approach can be used in models of continuing education and organizational management.
ARE THE 100 BEST BETTER? AN EMPIRICAL INVESTIGATION OF THE RELATIONSHIP BETWEEN BEING A “GREAT PLACE TO WORK” AND FIRM PERFORMANCE

We argue that positive employee relations effectively serves as an intangible and enduring asset, and may, therefore, be a source of sustained competitive advantage at the firm level. We survey a number of measures of firm-level performance and conceptualize how each measure is likely to be affected by highly positive firm-level employee relations. We then empirically investigate whether positive employee relations is related to firm performance, focusing on publicly traded firms included in the “100 Best Companies to Work for in America. ” The relative performance of these “Best Companies” is examined via comparisons to both companies in the broad market and a group of matched firms. Our analyses suggest that companies on the 100 Best list enjoy not only stable and highly positive workforce attitudes, but also performance advantages over the broad market, and in some cases, over the matched group.
Critical Thinking : A Literature

Critical thinking includes the component skills of analyzing arguments, making inferences using inductive or deductive reasoning, judging or evaluating, and making decisions or solving problems. Background knowledge is a necessary but not a sufficient condition for enabling critical thought within a given subject. Critical thinking involves both cognitive skills and dispositions. These dispositions, which can be seen as attitudes or habits of mind, include openand fair-mindedness, inquisitiveness, flexibility, a propensity to seek reason, a desire to be wellinformed, and a respect for and willingness to entertain diverse viewpoints. There are both generaland domain-specific aspects of critical thinking. Empirical research suggests that people begin developing critical thinking competencies at a very young age. Although adults often exhibit deficient reasoning, in theory all people can be taught to think critically. Instructors are urged to provide explicit instruction in critical thinking, to teach how to transfer to new contexts, and to use cooperative or collaborative learning methods and constructivist approaches that place students at the center of the learning process. In constructing assessments of critical thinking, educators should use open-ended tasks, real-world or “authentic” problem contexts, and ill-structured problems that require students to go beyond recalling or restating previously learned information. Such tasks should have more than one defensible solution and embed adequate collateral materials to support multiple perspectives. Finally, such assessment tasks should make student reasoning visible by requiring students to provide evidence or logical arguments in support of judgments, choices, claims, or assertions.
Carcinogen-induced Drug Resistance in Rat Hepatocytes1

The relative resistance of liver cells in primary monolayer cell culture to the cytocidal effects of methotrexate, Adriamycin, cycloheximide, or aflatoxin Bi was studied using cells derived from normal rats, rats subjected to two-thirds hepatectomy, or rats fed dietary carcinogen. Normal rat liver cells were highly sensitive to the toxic effects of methotrexate, Adriamycin, cycloheximide, and aflatoxin BI. In contrast, liver cells from carcinogen-treated rats were resistant to the toxic effects of these agents. Cells derived from rats at 24 hr post two-thirds hepatectomy were sensitive to Adriamycin but not to cyclohex imide or aflatoxin B,.
Are simultaneous interpreters expert bilinguals, unique bilinguals, or both?*

Simultaneous interpretation is a cognitively demanding process that requires a high level of language management. Previous studies on bilinguals have suggested that extensive practice managing two languages leads to enhancements in cognitive control. Thus, interpreters may be expected to show benefits beyond those seen in bilinguals, either as an extension of previously-seen benefits or in areas specific to interpretation. The present study examined professional interpreters (N = 23) and matched multilinguals (N = 21) on memory tests, the color-word Stroop task, the Attention Network Test, and a non-linguistic task-switching paradigm. The interpreters did not show advantages in conflict resolution or switching cost where bilingual benefits have been noted. However, an interpretation-specific advantage emerged on the mixing cost in the task-switching paradigm. Additionally, the interpreters had larger verbal and spatial memory spans. Interpreters do not continue to garner benefits from bilingualism, but they do appear to possess benefits specific to their experience with simultaneous interpretation.
Cellular Renewal and Improvement of Local Cell Effector Activity in Peritoneal Cavity in Response to Infectious Stimuli

The peritoneal cavity (PerC) is a singular compartment where many cell populations reside and interact. Despite the widely adopted experimental approach of intraperitoneal (i.p.) inoculation, little is known about the behavior of the different cell populations within the PerC. To evaluate the dynamics of peritoneal macrophage (MØ) subsets, namely small peritoneal MØ (SPM) and large peritoneal MØ (LPM), in response to infectious stimuli, C57BL/6 mice were injected i.p. with zymosan or Trypanosoma cruzi. These conditions resulted in the marked modification of the PerC myelo-monocytic compartment characterized by the disappearance of LPM and the accumulation of SPM and monocytes. In parallel, adherent cells isolated from stimulated PerC displayed reduced staining for β-galactosidase, a biomarker for senescence. Further, the adherent cells showed increased nitric oxide (NO) and higher frequency of IL-12-producing cells in response to subsequent LPS and IFN-γ stimulation. Among myelo-monocytic cells, SPM rather than LPM or monocytes, appear to be the central effectors of the activated PerC; they display higher phagocytic activity and are the main source of IL-12. Thus, our data provide a first demonstration of the consequences of the dynamics between peritoneal MØ subpopulations by showing that substitution of LPM by a robust SPM and monocytes in response to infectious stimuli greatly improves PerC effector activity.
Taking Stock of Innocence

This article offers a brief overview of the current state of the Innocence Movement. It begins by reviewing what we know, and do not know, about the incidence of wrongful convictions and their correlates and causes. It then explores select issues that should receive greater attention to help sustain the Innocence Movement and ensure its advancement. Acknowledging that much has been learned about wrongful convictions and that important reforms have been enacted, the article concludes by observing that significant challenges remain and must be addressed before efforts to guard against convicting the innocent are relaxed.