Miracle-dz/UniFAR-FTUs huggingface dataset:
Evidence for social learning in the self-presentation of alcohol problems.

AIMS To examine the extent to which problem alcohol users' self reports of drinking pattern and symptomatology derive primarily from a functional, learned social-cognitive schema (referred to as a 'script' in this paper), rather than from acts of recall or memory. METHODS Using a between-groups design with one repeated (within-subjects) measure, problem drinkers and non-problem drinkers were asked to complete a questionnaire about drinking behaviour and symptoms. Each group filled in the questionnaire twice, under both of two conditions. In condition one, they used the questionnaire to describe their own drinking and in condition two they were asked to describe the drinking of the other group (i.e. the problem drinkers filled out the questionnaire to describe non-problem drinking and the non-problem drinkers described problem drinking). RESULTS Using analyses of variance for the different sub-scales of the questionnaire, no overall differences were found between the two groups on four of the five subscales. However, clear and significant differences were found between the two conditions. That is, both groups were able to produce clearly differentiated scripts for both problem drinking and non-problem drinking. CONCLUSIONS These data, together with related data from other sources, suggest that 'scripts' for problem drinking and for non-problem drinking can be elicited from both problem-drinking and non-problem-drinking groups. The data support conclusions from an earlier study, suggesting that subjects may use learned 'scripts' rather than recall when responding to certain types of questionnaire instruments.
Improved saccharification and ethanol yield from field-grown transgenic poplar deficient in cinnamoyl-CoA reductase

Significance In the transition from a fossil-based to a bio-based economy, bioethanol will be generated from the lignocellulosic biomass of second-generation biofuel crops, such as poplar. The lignin polymers in the plant cell walls represent the main factor determining the recalcitrance of biomass to enzymatic processing. We have grown genetically modified poplars, down-regulated for cinnamoyl-CoA reductase (CCR), an enzyme in the lignin biosynthetic pathway, in field trials in Belgium and France. We show that wood samples derived from the transgenic trees are more easily processed into ethanol. However, strong down-regulation also affected biomass yield. In conclusion, CCR down-regulation may become a successful strategy to improve biomass processing if the yield penalty can be overcome. Lignin is one of the main factors determining recalcitrance to enzymatic processing of lignocellulosic biomass. Poplars (Populus tremula x Populus alba) down-regulated for cinnamoyl-CoA reductase (CCR), the enzyme catalyzing the first step in the monolignol-specific branch of the lignin biosynthetic pathway, were grown in field trials in Belgium and France under short-rotation coppice culture. Wood samples were classified according to the intensity of the red xylem coloration typically associated with CCR down-regulation. Saccharification assays under different pretreatment conditions (none, two alkaline, and one acid pretreatment) and simultaneous saccharification and fermentation assays showed that wood from the most affected transgenic trees had up to 161% increased ethanol yield. Fermentations of combined material from the complete set of 20-mo-old CCR–down-regulated trees, including bark and less efficiently down-regulated trees, still yielded ∼20% more ethanol on a weight basis. However, strong down-regulation of CCR also affected biomass yield. We conclude that CCR down-regulation may become a successful strategy to improve biomass processing if the variability in down-regulation and the yield penalty can be overcome.
GluR6/KA2 Kainate Receptors Mediate Slow-Deactivating Currents

Kainate receptors (KARs) are ionotropic glutamate receptors contributing to EPSCs with a slow-decaying component that is likely essential for synaptic integration. The slow kinetics of KAR-EPSCs markedly contrasts with the fast kinetics reported for recombinant KARs expressed in heterologous systems, for reasons that remain unexplained. Here we have studied the properties of recombinant heteromeric GluR6/KA2 receptors, which compose synaptic KARs. We report that, in response to brief glutamate applications, currents mediated by recombinant GluR6/KA2 receptors, but not GluR6 receptors, decay with a time course similar to KAR-EPSCs. Model simulations suggest that, after brief agonist exposures, GluR6/KA2 currents undergo slow deactivation caused by the stabilization of partially bound open states. We propose, therefore, that the GluR6/KA2 gating features could contribute to the slow KAR-EPSC decay kinetics.
Wind noise in hearing aids: I. Effect of wide dynamic range compression and modulation-based noise reduction

Abstract Objective: The objectives of this study were: (1) to examine the effect of wide dynamic range compression (WDRC) and modulation-based noise reduction (NR) algorithms on wind noise levels at the hearing aid output; and (2) to derive effective strategies for clinicians and engineers to reduce wind noise in hearing aids. Design: Three digital hearing aids were fitted to KEMAR. The noise output was recorded at flow velocities of 0, 4.5, 9.0, and 13.5 m/s in a wind tunnel as the KEMAR head was turned from 0° to 360°. Study sample: Flow noise levels were compared between the 1:1 linear and 3:1 WDRC conditions, and between NR-activated and NR-deactivated conditions when the hearing aid was programmed to the directional and omnidirectional modes. Results: The results showed that: (1) WDRC increased low-level noise and reduced high-level noise; and (2) different noise reduction algorithms provided different amounts of wind noise reduction in different microphone modes, frequency regions, flow velocities, and head angles. Conclusions: Wind noise can be reduced by decreasing the gain for low-level inputs, increasing the compression ratio for high-level inputs, and activating modulation-based noise reduction algorithms.
Assessment of physical activity – a review of methodologies with reference to epidemiological research: a report of the exercise physiology section of the European Association of Cardiovascular Prevention and Rehabilitation

Physical activity has a fundamental role in the prevention and treatment of chronic disease. The precise measurement of physical activity is key to many surveillance and epidemiological studies investigating trends and associations with disease. Public health initiatives aimed at increasing physical activity rely on the measurement of physical activity to monitor their effectiveness. Physical activity is multidimensional, and a complex behaviour to measure; its various domains are often misunderstood. Inappropriate or crude measures of physical activity have serious implications, and are likely to lead to misleading results and underestimate effect size. In this review, key definitions and theoretical aspects, which underpin the measurement of physical activity, are briefly discussed. Methodologies particularly suited for use in epidemiological research are reviewed, with particular reference to their validity, primary outcome measure and considerations when using each in the field. It is acknowledged that the choice of method may be a compromise between accuracy level and feasibility, but the ultimate choice of tool must suit the stated aim of the research. A framework is presented to guide researchers on the selection of the most suitable tool for use in a specific study.
Data modelling versus ontology engineering

Ontologies in current computer science parlance are computer based resources that represent agreed domain semantics. Unlike data models, the fundamental asset of ontologies is their relative independence of particular applications, i.e. an ontology consists of relatively generic knowledge that can be reused by different kinds of applications/tasks. The first part of this paper concerns some aspects that help to understand the differences and similarities between ontologies and data models. In the second part we present an ontology engineering framework that supports and favours the genericity of an ontology. We introduce the DOGMA ontology engineering approach that separates "atomic" conceptual relations from "predicative" domain rules. A DOGMA ontology consists of an ontology base that holds sets of intuitive context-specific conceptual relations and a layer of "relatively generic" ontological commitments that hold the domain rules. This constitutes what we shall call the double articulation of a DOGMA ontology 1.
Expression of estrogen and progesterone receptor genes in endometrium, myometrium and vagina of postmenopausal women treated with estriol

ABSTRACT CONTEXT AND OBJECTIVE: Estriol is an estrogen with considerably weaker stimulatory effects on endometrial proliferation than estradiol. A study was conducted to determine the level of estrogen receptors (ERs) and progesterone receptors (PRs) in women who received 14-day vaginal estriol therapy, compared with those who did not receive this therapy. ER and PR gene expression was analyzed in the endometrium, myometrium and vagina of postmenopausal women treated with estriol. DESIGN AND SETTING: Analytical cross-sectional study, at the Research Institute of the Polish Mothers’ Memorial Hospital, Lodz, Poland. METHODS: Twenty-seven postmenopausal women (57-74 years of age) were included in the study. All of them were waiting for per vaginam hysterectomy or plastic surgery on the vagina and perineum because of uterine prolapse. ER and PR gene expression was determined by means of the technique of reverse transcription polymerase chain reaction (RT-PCR). RESULTS: In the estriol-treated patients, in comparison with the control group, a significant increase in ER gene expression was observed in the endometrium and vagina, while enhanced PR gene expression was found in the endometrium. However, under histological examination of the endometrium, estrogen stimulation of low and medium degree was diagnosed for 21.4% and 14.3% of the estriol-treated women, respectively. CONCLUSION: The results obtained suggest that the women who received 14 days of treatment with vaginal estriol had higher ER and PR mRNA levels. No difference between these groups regarding endometrial proliferation was observed.
The effect of priming on the correlations between prominence ratings and acoustic features

In previous research we showed that the priming paradigm can be used to significantly alter the prominence ratings of subjects. In that study we only looked at the changes in the subjects’ ratings. In the present study, we analyzed the acoustic parameters of the stimuli used in the priming study and investigated the correlation between prominence ratings and acoustic parameters. The results show that priming has a significant effect on these correlations. The contribution of acoustic features on perceived prominence was found to depend on the prominence pattern. If a dominantly prominent syllable is present in a given utterance, f0 and intensity contribute most to the perceived prominence, while duration contributes most when no syllable is dominantly prominent. Index Terms: syllable, prominence, priming, acoustic correlates
Lack of in vivo and in vitro bactericidal activity of N-formimidoyl thienamycin against enterococci

The minimal bactericidal concentrations of N-formimidoyl thienamycin (N-f-thienamycin) against 21 strains of enterococci isolated from patients with infective endocarditis were determined by macro- and microdilution methods. By a macrodilution technique with the minimal bactericidal concentration defined as greater than or equal to 99.9% killing of an initial inoculum, all 21 strains of enterococci were found to have minimal bactericidal concentration/minimal inhibitory concentration ratios of greater than or equal to 32. The mean minimal inhibitory concentration was 1.5 micrograms/ml (range, 0.5 to 4 micrograms/ml), and the minimal bactericidal concentration was greater than or equal to 128 micrograms/ml. The disparity between the results of our study and those published elsewhere, which reported that N-f-thienamycin is bactericidal in vitro against enterococci, may represent the relative insensitivity of the microdilution method in determining greater than or equal to 99.9% killing. The lack of in vitro bactericidal activity of N-f-thienamycin against enterococci was confirmed in vivo in the rabbit model of experimental endocarditis. N-f-Thienamycin was no more effective than penicillin alone in the treatment of experimental enterococcal endocarditis and was less effective than the combination of penicillin and gentamicin. The results indicate that N-f-thienamycin should not be used alone in the treatment of enterococcal endocarditis.
Envelope analysis of intense relativistic quasilaminar beams in rf photoinjectors:mA theory of emittance compensation

In this paper we provide an analytical description for the transverse dynamics of relativistic, space-chargedominated beams undergoing strong acceleration, such as those typically produced by rf photoinjectors. These beams are chiefly characterized by a fast transition, due to strong acceleration, from the nonrelativistic to the relativistic regime in which the initially strong collective plasma effects are greatly diminished. However, plasma oscillations in the transverse plane are still effective in significantly perturbing the evolution of the transverse phase space distribution, introducing distortions and longitudinal-transverse correlations that cause an increase in the rms transverse emittance of the beam as a whole. The beam envelope evolution is dominated by such effects and not by the thermal emittance, and so the beam flow can be considered quasilaminar. The model adopted is based on the rms envelope equation, for which we find an exact particular analytical solution taking into account the effects of linear space-charge forces, external focusing due to applied as well as ponderomotive RF forces, acceleration, and adiabatic damping, in the limit that the weak nonlaminarity due to the thermal emittance may be neglected. This solution represents a special mode for beam propagation that assures a secularly diminishing normalized rms emittance and it represents the fundamental operating condition of a space-charge-compensated RF photoinjector. The conditions for obtaining emittance compensation in a long, integrated photoinjector, in which the gun and linac sections are joined, as well as in the case of a short gun followed by a drift and a booster linac, are examined. @S1063-651X~97! 10706-1#
Endoplasmic reticulum stress is a mediator of posttransplant injury in severely steatotic liver allografts

Hepatic steatosis continues to present a major challenge in liver transplantation. These organs have been shown to have increased susceptibility to cold ischemia/reperfusion (CIR) injury in comparison with otherwise comparable lean livers; the mechanisms governing this increased susceptibility to CIR injury are not fully understood. Endoplasmic reticulum (ER) stress is an important link between hepatic steatosis, insulin resistance, and metabolic syndrome. In this study, we investigated ER stress signaling and blockade in the mediation of CIR injury in severely steatotic rodent allografts. Steatotic allografts from genetically leptin‐resistant rodents had increased ER stress responses and increased markers of hepatocellular injury after liver transplantation into strain‐matched lean recipients. ER stress response components were reduced by the chemical chaperone taurine‐conjugated ursodeoxycholic acid (TUDCA), and this resulted in an improvement in the allograft injury. TUDCA treatment decreased nuclear factor kappa B activation and the proinflammatory cytokines interleukin‐6 and interleukin‐1β. However, the predominant response was decreased expression of the ER stress cell death mediator [CCAAT/enhancer‐binding protein homologous protein (CHOP)]. Furthermore, activation of inflammation‐associated caspase‐11 was decreased, and this linked ER stress/CHOP to proinflammatory cytokine production after steatotic liver transplantation. These data confirm ER stress in steatotic allografts and implicate this as a mediating mechanism of inflammation and hepatocyte death in the steatotic liver allograft. Liver Transpl 17:189–200, 2011. © 2011 AASLD
Plasma concentration profiles of ketamine and norketamine after administration of various ketamine preparations to healthy Japanese volunteers

Ketamine is known to provide analgesic effects without an anesthetic when administered in a low dose. We previously reported that a tablet containing ketamine had analgesic effects in patients with neuropathic pain. In the present study, we compared the plasma concentration profiles of the enantiomers of ketamine and its active metabolite, norketamine, up to 8 h after the administration of 20 mg of ketamine by injection, after the administration of two tablets containing 25 mg of ketamine, after the administration of two sublingual tablets containing 25 mg of ketamine, after the insertion of a suppository containing 50 mg of ketamine, and after the application of a nasal spray containing 25 mg of ketamine to three healthy volunteers. The plasma concentration of ketamine biexponentially declined after the administration by injection; the value of T1/2β for ketamine was approximately 120 min. The bioavailability of the tablet was estimated to be approximately 20%; the area under the plasma concentration–time curve, (AUC)0→8 h, of norketamine was approximately 500 ng h/ml in both enantiomers. The bioavailabilities of the sublingual tablet and the suppository were estimated to both be approximately 30%; the AUC0→8 h of norketamine was 280–460 ng h/ml in both enantiomers. The plasma concentration profiles of the sublingual tablet and the suppository were almost similar to that of the tablet. The bioavailability of the nasal spray was estimated to be approximately 45%, which was the highest value among the preparations tested, and the AUC0→6 h of norketamine was low (approximately 100 ng h/ml) in both enantiomers. These pharmacokinetic findings suggested that all of the ketamine preparations tested in this study may be useful for the alleviation of neuropathic pain. We propose that the type of ketamine preparation should be selected in accordance with the patient's disease condition and the required dosage amount of ketamine. Copyright © 2002 John Wiley & Sons, Ltd.
Producing Edge City: Publics, Perceptions, and the Right to Life on the New Frontier

This thesis explores Oak Brook, IL, an edge city (Garreau 1991) in the western suburbs of Chicago. A number of authors have advanced criticisms of edge cities (Beauregard 1995; Marcuse 1997), including that they are particularly exploitative and exclusionary. Some authors have claimed that edge cities are a “new frontier” (Garreau 1991), while others suggest that they are nothing new at all (Walker 1994). I address these concerns by way of an in-depth engagement with Oak Brook, Chicago’s truest edge city. I ultimately argue that while edge cities have unique characteristics, they are part of a long heritage of capitalist urban geographies. Throughout the thesis, I use the case of Oak Brook to understand the exploitative and exclusionary dimensions of edge cities. I also examine how landscapes and perceptions of place impact life in edge cities, and how seemingly small changes in the landscape can have significant impacts to place images and to political economy. Seeing such changes and the struggles to realize them as part of a larger project to change urban life, I argue, is an important part of understanding edge cities within their metropolitan contexts. PRODUCING EDGE CITY: PUBLICS, PERCEPTIONS, AND THE RIGHT TO LIFE ON THE NEW FRONTIER
An Equivalence Between Sparse Approximation and Support Vector Machines

This article shows a relationship between two different approximation techniques: the support vector machines (SVM), proposed by V. Vapnik (1995) and a sparse approximation scheme that resembles the basis pursuit denoising algorithm (Chen, 1995; Chen, Donoho, & Saunders, 1995). SVM is a technique that can be derived from the structural risk minimization principle (Vapnik, 1982) and can be used to estimate the parameters of several different approximation schemes, including radial basis functions, algebraic and trigonometric polynomials, B-splines, and some forms of multilayer perceptrons. Basis pursuit denoising is a sparse approximation technique in which a function is reconstructed by using a small number of basis functions chosen from a large set (the dictionary). We show that if the data are noiseless, the modified version of basis pursuit denoising proposed in this article is equivalent to SVM in the following sense: if applied to the same data set, the two techniques give the same solution, which is obtained by solving the same quadratic programming problem. In the appendix, we present a derivation of the SVM technique in the framework of regularization theory, rather than statistical learning theory, establishing a connection between SVM, sparse approximation, and regularization theory.
Toward a Taxonomy of Copresence

This paper contributes to the presence literature by explicating the meanings and subtypes of copresence.Copresence is defined here as consisting of two dimensions: copresence as mode of being with others, and copresence as sense of being with others. Mode of copresence refers to the physical conditions that structure human interaction. Six such conditions are delineated. Sense of copresence, on the other hand, refers to the subjective experience of being with others that an individual acquires in interaction. The main argument of this paper is that mode of copresence affects sense of copresence, and knowledge of how the former affects the latter will benefit copresence design.
Properties of amorphous GaN from first-principles simulations

Amorphous GaN (a-GaN) models are obtained from first-principles simulations. We compare four a-GaN models generated by “melt-and-quench” and the computer alchemy method. We find that most atoms tend to be fourfold, and a chemically ordered continuous random network is the ideal structure for a-GaN albeit with some coordination defects. Where the electronic structure is concerned, the gap is predicted to be less than 1.0 eV, underestimated as usual by a density functional calculation. We observe a highly localized valence tail and a remarkably delocalized exponential conduction tail in all models generated. Based upon these results, we speculate on potential differences in nand p-type doping. The structural origin of tail and defect states is discussed. The vibrational density of states and dielectric function are computed and seem consistent with experiment.