Miracle-dz/UniFAR-FTUs huggingface dataset:
On combining support vector machines and simulated annealing in stereovision matching

This paper outlines a method for solving the stereovision matching problem using edge segments as the primitives. In stereovision matching, the following constraints are commonly used: epipolar, similarity, smoothness, ordering, and uniqueness. We propose a new strategy in which such constraints are sequentially combined. The goal is to achieve high performance in terms of correct matches by combining several strategies. The contributions of this paper are reflected in the development of a similarity measure through a support vector machines classification approach; the transformation of the smoothness, ordering and epipolar constraints into the form of an energy function, through an optimization simulated annealing approach, whose minimum value corresponds to a good matching solution and by introducing specific conditions to overcome the violation of the smoothness and ordering constraints. The performance of the proposed method is illustrated by comparative analysis against some recent global matching methods.
Color Constancy with Derivative Colors

Information about the illuminant color is well contained in both achromatic regions and the specular components of highlight regions. In this paper, we propose a novel way to achieve color constancy by exploiting such clues. The key to our approach lies in the use of suitably extracted derivative colors, which are able to compute the illuminant color robustly with kernel density estimation. While extracting derivative colors from achromatic regions to approximate the illuminant color well is basically straightforward, the success of our extraction in highlight regions is attributed to the different rates of variation of the diffuse and specular magnitudes in the dichromatic reflection model. The proposed approach requires no training phase and is simple to implement. More significantly, it performs quite satisfactorily under inter-database parameter settings. Our experiments on three standard databases demonstrate its effectiveness and fine performance in comparison to state-of-the-art methods.
Interdisciplinarity and the undergraduate biology curriculum: finding a balance.

A variety of recent reports, notably Bio2010 from the National Research Council (NRC, 2003 ; but see also CUPM Curriculum Guide [Mathematical Association of America, 2004 ], Salem and Dilts (2004) , Meeting the Challenges (2003) , and the collection of teaching material compiled by the Society for Mathematical Biology at http://www.smb. org/teaching/), recommend that undergraduate biology preparation become more interdisciplinary. This is based on the realization that modern biology research requires a breadth of skills that go well beyond the limited set of experiences that undergraduate biologists are exposed to in their traditional biology courses. This is not limited to biology, of course, for physical scientists have long been aware of the interconnections between fields and the reliance on quantitative approaches that go well beyond the basic undergraduate mathematics to which most physical science students are exposed.
Impact of mitochondrial telomerase over-expression on drug resistance of hepatocellular carcinoma.

BACKGROUND The efficacy of chemotherapy in patients with hepatocellular carcinomas still poor due to multidrug resistance. This study aimed to investigate the impact of the over-expressed mitochondrial human telomerase reverse transcriptase on multidrug resistance of hepatocellular carcinomas. METHODS HepG2 and SK-Hep1 cell lines were used. And sensitivity to chemotherapeutic drugs was detected. RESULTS Mitochondrial human telomerase reverse transcriptase over-expression in hepatocellular carcinomas cells could significantly reduce its sensitivity to multiple chemotherapeutic drugs in vitro and in vivo. Hepatocellular carcinomas cells over-expressing mitochondrial human telomerase reverse transcriptase showed a significantly higher mitochondrial membrane potential, a markedly lower activated caspase-3 after drug treatment, and an increased mtDNA copy number, which explained the drastically decreased drug-induced apoptosis of hepatocellular carcinomas cells with mitochondrial human telomerase reverse transcriptase over-expression. CONCLUSION Over-expressed mitochondrial human telomerase reverse transcriptase may increase the mtDNA copy number and inhibit the activation of mitochondrial apoptotic pathway to contribute to the multidrug resistance of hepatocellular carcinomas cells.
Treatment of patients with gastric variceal hemorrhage: Endoscopic N‐butyl‐2‐cyanoacrylate injection versus balloon‐occluded retrograde transvenous obliteration

Background and Aim: Our study aimed to evaluate the therapeutic results of endoscopic N‐butyl‐2‐cyanoacrylate injection (EBC) and balloon‐occluded retrograde transvenous obliteration (BRTO) in patients with gastric variceal hemorrhage (GVH) and/or high‐risk gastric varices (GV).
Endothelin regulates intermittent hypoxia‐induced lipolytic remodelling of adipose tissue and phosphorylation of hormone‐sensitive lipase

Endothelin‐1 (ET‐1) is upregulated upon intermittent hypoxia and has lipolytic effects. Intermittent hypoxia induces adipose tissue lipolysis that may be mediated by ET‐1. In the present study, we show that ET‐1 is involved in adipose tissue remodelling induced by intermittent hypoxia and that phosphorylation of hormone‐sensitive lipase could be one mechanism mediating this effect. We also show that ET‐1 upregulates its own and its type A endothelin receptor expression, possibly leading to an autoactivatory loop. These results help us better understand the mechanisms of dyslipidaemia in disorders associated with intermittent hypoxia, such as obstructive sleep apnoea.
Sensitization of Nociceptive Ion Channels by Inhaled Anesthetics—A Pain in the Gas?

A remarkable new article in this issue of Molecular Pharmacology (p. 1261) shows that the capsaicin-sensitive ion channel TRPV1 is sensitized to activation by chemical and physical stimuli in the presence of inhaled general anesthetics. This finding provides another example of an ion channel in which the anesthetic acts to modify channel gating. This may have important clinical implications in view of the role of TRPV1 in nociception.
Business associations and labor unions in comparison: theoretical perspectives and empirical findings on social class, collective action and associational organizability

L'article etudie l'effet de la classe sociale sur l'organisation des associations de travailleurs et d'interets capitalistes. A cette fin, l'A. s'appuie sur les theories de l'action collective, des classes sociales et des organisations et examine en particulier les approches de certains theoriciens a ce sujet
Remote Sensing and GIS Techniques for Evaluation of Groundwater Quality in Municipal Corporation of Hyderabad (Zone-V), India

Groundwater quality in Hyderabad has special significance and needs great attention of all concerned since it is the major alternate source of domestic, industrial and drinking water supply. The present study monitors the ground water quality, relates it to the land use / land cover and maps such quality using Remote sensing and GIS techniques for a part of Hyderabad metropolis. Thematic maps for the study are prepared by visual interpretation of SOI toposheets and linearly enhanced fused data of IRS-ID PAN and LISS-III imagery on 1:50,000 scale using AutoCAD and ARC/INFO software. Physico-chemical analysis data of the groundwater samples collected at predetermined locations forms the attribute database for the study, based on which, spatial distribution maps of major water quality parameters are prepared using curve fitting method in Arc View GIS software. Water Quality Index (WQI) was then calculated to find the suitability of water for drinking purpose. The overall view of the water quality index of the present study area revealed that most of the study area with > 50 standard rating of water quality index exhibited poor, very poor and unfit water quality except in places like Banjara Hills, Erragadda and Tolichowki. Appropriate methods for improving the water quality in affected areas have been suggested.
Do it Yourself: Video Self-Modeling Made Easy

Elaine, a tutor, and Carlo, a fourth-grader, sit together at a table with a laptop. They discuss the book that Carlo is about to read, which Carlo chose from a set of preselected books at his instructional level. Elaine and Carlo discuss the cover of the book before starting to read, then they read a few pages in unison. After 2 minutes of unison reading, Elaine reaches over to the laptop, hits a button, and starts recording the rest of their tutoring session on video
Cutaneous innervation in sensory neuropathies

Objective: To use punch skin biopsies to evaluate the loss of intra-epidermal nerve fibers in sensory neuropathies. Background: Previous assessments of epidermal nerve fibers have been constrained by relatively insensitive staining techniques and variability in quantification. Methods: Punch skin biopsies were performed on the heel and leg of HIV-seronegative controls, HIV-seropositive individuals without neuropathy, and patients with sensory neuropathies, including HIV-seronegative and HIV-positive individuals. After formalin fixation, 50-micro meter free-floating sections were stained with a monoclonal antibody to neuron-specific ubiquitin hydrolase, PGP9.5. The number of intraepidermal fibers/mm in at least three sections from each patient was counted by one observer blinded to site and clinical status. Results: Dermal and epidermal nerve fibers were readily identified and quantified. The immunostaining technique reliably demonstrated a dermal plexus of myelinated and unmyelinated fibers parallel to the surface of the skin. In the epidermis, unmyelinated fibers ascended vertically between the keratinocytes to reach the stratum corneum. The number of intra-epidermal fibers/mm in the distal leg (mean plus minus SEM) was 17.84 plus minus 3.03 in seven HIV-seronegative controls. Epidermal fiber number was significantly reduced (p equals 0.01) in five HIV-infected patients with sensory neuropathies associated with didanosine or zalcitabine therapy (1.07 plus minus 0.40) and in eight HIV-seronegative patients with sensory neuropathies (3.1 plus minus 3.1). Four of five neurologically normal HIV-seropositive subjects had reduced numbers of epidermal fibers, suggesting a subclinical neuropathy. Serial biopsies in one individual demonstrated the evolution of degenerating epidermal fibers after development of zalcitabine-induced sensory neuropathy. Conclusion: Skin biopsies stained with the sensitive panaxonal marker anti-PGP9.5 demonstrated significant reduction in intraepidermal fibers in sensory neuropathies. This simple and repeatable technique is a reliable method for quantitation of small cutaneous sensory fibers. In addition, skin biopsies may be useful in assessing the course and spatial distribution of involvement in peripheral nerve disease. NEUROLOGY 1995;45: 1848-1855
Workers after Workers' States: Labor and Politics in Postcommunist Eastern Europe

Chapter 1 Introduction: The Surprise of Labor Weakness in Post-Communist Society Chapter 2 Labor and Trade Unions in the Czech Republic, 1989-2000 Chapter 3 The Failure of Social-Democratic Unionism in Hungary Chapter 4 Neocorporatism in Slovakia: Formalizing Labor Weakness in a (Re)democratizing State Chapter 5 The Weakness of Symbolic Strength: Labor and Union Identity in Poland: 1989-2000 Chapter 6 Winning the Battles, Losing the War: Contradictions of Romanian Labor in the Post-Communist Transformation Chapter 7 Bulgarian Trade Unions in Transition: The Taming of the Hedgehog Chapter 8 The Cost of Nationalism: Croatian Labor, 1990 - 1999 Chapter 9 Waiting for the Workers: Explaining Labor Quiescence in Serbia Chapter 10 Workers and Unions in Postcommunist Ukraine Chapter 11 The Social Explosion That Wasn't: Labor Quiescence in Post-Communist Russia Chapter 12 Conclusion: Making Sense of Labor's Weakness in Poscommunism
Improved Recharge Estimation from Portable, Low‐Cost Weather Stations

Groundwater recharge estimation is a critical quantity for sustainable groundwater management. The feasibility and robustness of recharge estimation was evaluated using physical‐based modeling procedures, and data from a low‐cost weather station with remote sensor techniques in Southern Abbotsford, British Columbia, Canada. Recharge was determined using the Richards‐based vadose zone hydrological model, HYDRUS‐1D. The required meteorological data were recorded with a HOBOTM weather station for a short observation period (about 1 year) and an existing weather station (Abbotsford A) for long‐term study purpose (27 years). Undisturbed soil cores were taken at two locations in the vicinity of the HOBOTM weather station. The derived soil hydraulic parameters were used to characterize the soil in the numerical model. Model performance was evaluated using observed soil moisture and soil temperature data obtained from subsurface remote sensors. A rigorous sensitivity analysis was used to test the robustness of the model. Recharge during the short observation period was estimated at 863 and 816 mm. The mean annual recharge was estimated at 848 and 859 mm/year based on a time series of 27 years. The relative ratio of annual recharge‐precipitation varied from 43% to 69%. From a monthly recharge perspective, the majority (80%) of recharge due to precipitation occurred during the hydrologic winter period. The comparison of the recharge estimates with other studies indicates a good agreement. Furthermore, this method is able to predict transient recharge estimates, and can provide a reasonable tool for estimates on nutrient leaching that is often controlled by strong precipitation events and rapid infiltration of water and nitrate into the soil.
Andropause Syndrome in Men Treated for Metastatic Prostate Cancer: A Qualitative Study of the Impact of Symptoms

Background:Androgen deprivation therapy (ADT) has become the cornerstone of treatment for men with metastatic prostate cancer. However, treatments are associated with a number of adverse effects that collectively are referred to as andropause syndrome, or the male menopause. Objective:This study explored the experience and impact of andropause symptoms, particularly hot flashes, among men undergoing ADT for metastatic prostate cancer. Methods:Twenty-one men receiving ADT for metastatic prostate cancer underwent a qualitative interview focusing on the adverse effects of ADT and the impact of these symptoms on daily living and coping strategies. Results:The most frequently mentioned adverse effects were hot flashes and night sweats, gynecomastia, cognitive decline, and changes in sexual function. Hot flashes did impact on everyday functioning, and night sweats regularly disturbed sleep patterns and led to participants feeling tired and irritable. Participants reported a lack of control over their hot flashes and night sweats. There was reluctance among our sample to disclose the type of symptoms experienced to others. Conclusion:The occurrence of andropause symptoms, including hot flashes and night sweats, was common among this sample. Participants reported a range of cognitive and behavioral responses to these symptoms. There was some reluctance about discussing a prostate cancer diagnosis or the occurrence of symptoms with others. Implications for Practice:The findings have implications for a range of individual and couple interventions to manage the impact of this constellation of symptoms.
Managed communication and consistency for fast data-parallel iterative analytics

At the core of Machine Learning (ML) analytics is often an expert-suggested model, whose parameters are refined by iteratively processing a training dataset until convergence. The completion time (i.e. convergence time) and quality of the learned model not only depends on the rate at which the refinements are generated but also the quality of each refinement. While data-parallel ML applications often employ a loose consistency model when updating shared model parameters to maximize parallelism, the accumulated error may seriously impact the quality of refinements and thus delay completion time, a problem that usually gets worse with scale. Although more immediate propagation of updates reduces the accumulated error, this strategy is limited by physical network bandwidth. Additionally, the performance of the widely used stochastic gradient descent (SGD) algorithm is sensitive to step size. Simply increasing communication often fails to bring improvement without tuning step size accordingly and tedious hand tuning is usually needed to achieve optimal performance. This paper presents Bösen, a system that maximizes the network communication efficiency under a given inter-machine network bandwidth budget to minimize parallel error, while ensuring theoretical convergence guarantees for large-scale data-parallel ML applications. Furthermore, Bösen prioritizes messages most significant to algorithm convergence, further enhancing algorithm convergence. Finally, Bösen is the first distributed implementation of the recently presented adaptive revision algorithm, which provides orders of magnitude improvement over a carefully tuned fixed schedule of step size refinements for some SGD algorithms. Experiments on two clusters with up to 1024 cores show that our mechanism significantly improves upon static communication schedules.
Age and regional differences in clinical presentation and risk of hospitalization for dengue in Brazil, 2000-2014

OBJECTIVES: Dengue cases range from asymptomatic to severe, eventually leading to hospitalization and death. Timely and appropriate management is critical to reduce morbidity. Since 1980, dengue has spread throughout Brazil, affecting an increasing number of individuals. This paper describes age and regional differences in dengue’s clinical presentation and associated risk of hospitalization based on more than 5 million cases reported to the Brazilian Ministry of Health from 2000-2014. METHODS: We performed a retrospective analysis of ∼5,450,000 dengue cases, relating clinical manifestations and the risk of hospitalization to age, gender, previous infection by dengue, dengue virus serotype, years of formal education, delay to first attendance and the occurrence of dengue during outbreaks and in different Brazilian regions. RESULTS: Complicated forms of dengue occurred more frequently among those younger than 10 years (3.12% vs 1.92%) and those with dengue virus 2 infection (7.65% vs 2.42%), with a delay to first attendance >2 days (3.18% vs 0.82%) and with ≤4 years of formal education (2.02% vs 1.46%). The risk of hospitalization was higher among those aged 6-10 years old (OR 4.57; 95% CI 1.43-29.96) and those who were infected by dengue virus 2 (OR 6.36; 95% CI 2.52-16.06), who lived in the Northeast region (OR 1.38; 95% CI 1.11-2.10) and who delayed first attendance by >5 days (composite OR 3.15; 95% CI 1.33-8.9). CONCLUSIONS: In Brazil, the occurrence of severe dengue and related hospitalization is associated with being younger than 10 years old, being infected by dengue virus 2 or 3, living in the Northeast region (the poorest and the second most populated) and delaying first attendance for more than 2 days.
Inhibition of p38 MAPK diminishes doxorubicin-induced drug resistance associated with P-glycoprotein in human leukemia K562 cells

Summary Background Several studies have shown that multidrug transporters, such as P-glycoprotein (PGP), are involved in cell resistance to chemotherapy and refractory epilepsy. The p38 mitogen-activated protein kinase (MAPK) signaling pathway may increase PGP activity. However, p38-mediated drug resistance associated with PGP is unclear. Here, we investigated p38-mediated doxorubicin-induced drug resistance in human leukemia K562 cells. Material/Methods The expression of PGP was detected by RT-PCR, Western blot, and immunocytochemistry. Cell viability and half-inhibitory concentrations (IC50) were determined by CCK-8 assay. The intracellular concentration of drugs was measured by HPLC. Results A doxorubicin-induced PGP overexpression cell line, K562/Dox, was generated. The p38 inhibitor SB202190 significantly decreased MDR1 mRNA expression, as well as PGP, in K562/Dox cells. The IC50 of phenytoin sodium and doxorubicin in K562/Dox cells was significantly higher than that in wild-type K562 cells, indicating the drug resistance of K562/Dox cells. During the blocking of p38 activity in the presence of SB202190, cell number was significantly reduced after the phenytoin sodium and doxorubicin treatment, and the IC50 of phenytoin sodium and doxorubicin was decreased in K562/Dox cells. HPLC showed that the intracellular levels of phenytoin sodium and doxorubicin were significantly lower in K562/Dox cells than those in K562 cells. The decrease of the intracellular level of these drugs was significantly abolished in the presence of SB202190. Conclusions Our study demonstrated that p38 is, at least in part, involved in doxorubicin-induced drug resistance. The mechanistic study of MAPK-mediated PGP and the action of SB202190 need further investigation.
Global mitotic phosphorylation of C2H2 zinc finger protein linker peptides

Cessation of transcriptional activity is a hallmark of cell division. Many biochemical pathways have been shown and proposed over the past few decades to explain the silence of this phase. In particular, many individual transcription factors have been shown to be inactivated by phosphorylation. In this report, we show the simultaneous phosphorylation and mitotic redistribution of a whole class of modified transcription factors. C2H2 zinc finger proteins (ZFPs) represent the largest group of gene expression regulators in the human genome. Despite their diversity, C2H2 ZFPs display striking conservation of small linker peptides joining their adjacent zinc finger modules. These linkers are critical for DNA binding activity. It has been proposed that conserved phosphorylation of these linker peptides could be a common mechanism for the inactivation of the DNA binding activity of C2H2 ZFPs, during mitosis. Using a novel antibody, raised against the phosphorylated form of the most conserved linker peptide sequence, we are able to visualize the massive and simultaneous mitotic phosphorylation of hundreds of these proteins. We show that this wave of phosphorylation is tightly synchronized, starting in mid-prophase right after DNA condensation and before the breakdown of the nuclear envelope. This global phosphorylation is completely reversed in telophase. In addition, the exclusion of the phospho-linker signal from condensed DNA clearly demonstrates a common mechanism for the mitotic inactivation of C2H2 ZFPs.