Miracle-dz/UniFAR-FTUs huggingface dataset:
Independent Predictive Factors of Hospitalization in a North-West Burn Center of Iran; an Epidemiologic Study

Introduction: A high-grade burn is one of the most devastating injuries with several medical, social, economic, and psychological effects. These injuries are the most common cause of accidental deaths after traffic injuries in both the developed and developing countries. Therefore, this research was aimed to determine demographic characteristics of patients with burn injury admitted to the emergency department and identify predictive factors of hospitalization. Methods: This is a cross sectional descriptive study, which is done in 20 March up to 20 September 2011 in emergency department of Sina Hospital, Tabriz, Iran. Patients’ information including demographic characteristic, cause of burn, place of accident, anatomical areas burned, grading and percent of burning and disposition were gathered and analyzed using SPSS version 18.0 statistical software. Stepwise multivariate regression analysis was used for recognition of independent predictive factors of hospitalization in burned patients. Results: One hundred and sixty patients were enrolled (54.4% female). The average age of those was 20.47±13.5 years. The prevalence of burn was significantly higher in ages under 20 years (p<0.001). Lower limb (37.5%), head and neck (21.25%) and upper limb (17.5%) were three frequent site of burn. The most common cause of burns was boiling water scalding (34.4%). Home related burn was significantly higher than other place (p<0.001). The most frequent percent of burn was <5% (46.25%). Finally, 50 (31.25%) cases hospitalized. Univariate analysis demonstrated that age under 20 years old (p=0.02) female gender (p=0.02), burning site (p=0.002), cause (p=0.005), place (p<0.001), grade (p<0.001), and percent (p<0.001) was related to disposition of patients. Stepwise multiple logistic regression showed female gender (OR=3.52; 95% CI: 1.57-7.88; p=0.002), work related burning (OR=1.78; 95% CI: 1.26-2.52; p=0.001), and burning over 5 percent (OR=2.15; 95% CI: 1.35-3.41; p=0.001) as independent predictive factors of hospitalization. Conclusion: The results of present study showed that burns injury are most frequent in age under 20 year old, lower limbs, with boiling water, and at home. In addition, the most frequent type and percentage of burned area were second degree and <5% of total body surface area, respectively. Among age under 20 years old, female gender, burning site, cause, place, grade, and percent only female gender, work related burning, and burning over 5% were detected as independent predictive factors of hospitalization.
Analysis of the Precautionary Saving Motive Based on a Subjective Measure : (SAVE 2005-2007)

The importance of the precautionary saving motive for households’ saving behaviour is unquestioned in the literature of the last two decades. However, the magnitude of precautionary savings and its influencing factors could not be satisfactorily determined. A subjective measure of the desired amount of precautionary savings in the German SAVE study 2005-2007 allows for the evaluation of these questions on a new basis without relying on a specific definition of wealth. This study supports the view of a low or at most moderate contribution of precautionary savings to wealth accumulation ranging from 6% for total net wealth to 26% for financial wealth. Carroll’s buffer-stock model (1992, 1997) is introduced since it establishes the theoretical foundation of this study. In a multivariate data analysis, the panel structure and the wide range of theoretically relevant variables available in the SAVE datasets allows investigating the factors which influence the subjective measure of the desired amount of precautionary savings. Education, current income, variables which reflect a precautionary attitude, bequest and old-age provision motives have strong and significant effects in the expected way. The variables for individual income risk have the expected sign over all specifications. However, they remain insignificant at the usual significance levels, which can be due to the construction of these variables or the German social insurance and welfare system.
Regulation of the Neural Circuitry of Emotion by Compassion Meditation: Effects of Meditative Expertise

Recent brain imaging studies using functional magnetic resonance imaging (fMRI) have implicated insula and anterior cingulate cortices in the empathic response to another's pain. However, virtually nothing is known about the impact of the voluntary generation of compassion on this network. To investigate these questions we assessed brain activity using fMRI while novice and expert meditation practitioners generated a loving-kindness-compassion meditation state. To probe affective reactivity, we presented emotional and neutral sounds during the meditation and comparison periods. Our main hypothesis was that the concern for others cultivated during this form of meditation enhances affective processing, in particular in response to sounds of distress, and that this response to emotional sounds is modulated by the degree of meditation training. The presentation of the emotional sounds was associated with increased pupil diameter and activation of limbic regions (insula and cingulate cortices) during meditation (versus rest). During meditation, activation in insula was greater during presentation of negative sounds than positive or neutral sounds in expert than it was in novice meditators. The strength of activation in insula was also associated with self-reported intensity of the meditation for both groups. These results support the role of the limbic circuitry in emotion sharing. The comparison between meditation vs. rest states between experts and novices also showed increased activation in amygdala, right temporo-parietal junction (TPJ), and right posterior superior temporal sulcus (pSTS) in response to all sounds, suggesting, greater detection of the emotional sounds, and enhanced mentation in response to emotional human vocalizations for experts than novices during meditation. Together these data indicate that the mental expertise to cultivate positive emotion alters the activation of circuitries previously linked to empathy and theory of mind in response to emotional stimuli.
Alexander Disease Mutant Glial Fibrillary Acidic Protein Compromises Glutamate Transport in Astrocytes

Alexander disease (AxD) is a leukodystrophy caused by heterozygous mutations in the gene for glial fibrillary acidic protein, an intermediate filament protein expressed by astrocytes. The mutation causes prominent protein aggregates inside astrocytes; there is also loss of myelin and oligodendrocytes and neuronal degeneration. We show that immunohistochemical staining for glutamate transporter 1, the major brain glutamate transporter expressed primarily in astrocytes suggests decreased levels in the hippocampi of infantile AxD patients. A knock-in mouse model of AxD also shows significant reduction of glutamate transporter 1 in the hippocampus. To explore this phenomenon at the cellular level, wild-type and R239C mutant glial fibrillary acidic proteins (the most common mutation) were overexpressed in astrocytes in culture. Western blotting and whole-cell patch clamp recordings demonstrated that the R239C astrocytes exhibited markedly reduced glutamate transporter 1 protein levels; this resulted in attenuated or abolished glutamate-induced inward transporter current. Neurons cocultured with the R239C astrocytes exhibited increased death after glutamate challenge. These results indicate that aberrant astrocytes have decreased glutamate uptake, which may play an important role in the pathogenesis of neuronal and oligodendrocyte injury and death in AxD.
Trastuzumab in Esophagogastric Cancer: HER2-Testing and Treatment Reality outside Clinical Studies in Germany

We analysed trends over time in palliative first-line chemotherapy in patients with locally advanced or metastatic esophagogastric cancer. Special focus was on frequency and quality of HER2-testing and trends in drug use in combination with trastuzumab. Earlier published data about patients treated outside clinical studies showed a relatively low rate of HER2-testing and insufficient test quality. A total of 2,808 patients retrospectively documented in Therapiemonitor® from 2006 to 2013 were analysed regarding treatment intensity and trends in used drugs. Data on HER2-testing and therapies were analysed in two cohorts documented in 2010 and 2011 (1) compared to 2012 and 2013 (2). Treatment intensity increased: 49.3% of patients received at least a triplet in 2013 compared to 10.1% in 2006. In cohort 2 HER2 expression was tested in 79.1% of the cases. Still, in 26.9% testing was not done as requested by guidelines. Good performance status, multiple metastases, age ≤ 65 years, the objective “to prevent progression,” good cognitive capabilities, estimated good compliance, and social integration positively influenced the probability of HER2-testing; comorbidities negatively affected it. Usage of the combination of fluoropyrimidines and cisplatin with trastuzumab declined from 67% in cohort 1 to 50% in cohort 2.
Species Delimitation and Interspecific Relationships of the Genus Orychophragmus (Brassicaceae) Inferred from Whole Chloroplast Genomes

Genetic variations from few chloroplast DNA fragments show lower discriminatory power in the delimitation of closely related species and less resolution ability in discerning interspecific relationships than from nrITS. Here we use Orychophragmus (Brassicaceae) as a model system to test the hypothesis that the whole chloroplast genomes (plastomes), with accumulation of more variations despite the slow evolution, can overcome these weaknesses. We used Illumina sequencing technology via a reference-guided assembly to construct complete plastomes of 17 individuals from six putatively assumed species in the genus. All plastomes are highly conserved in genome structure, gene order, and orientation, and they are around 153 kb in length and contain 113 unique genes. However, nucleotide variations are quite substantial to support the delimitation of all sampled species and to resolve interspecific relationships with high statistical supports. As expected, the estimated divergences between major clades and species are lower than those estimated from nrITS probably due to the slow substitution rate of the plastomes. However, the plastome and nrITS phylogenies were contradictory in the placements of most species, thus suggesting that these species may have experienced complex non-bifurcating evolutions with incomplete lineage sorting and/or hybrid introgressions. Overall, our case study highlights the importance of using plastomes to examine species boundaries and establish an independent phylogeny to infer the speciation history of plants.
Disk Sizes in a ΛCDM Universe

Abstract We introduce a model which uses semi-analytic techniques to trace formation and evolution of galaxy disks in their cosmological context. For the first time we model the growth of gas and stellar disks separately. In contrast to previous work we follow in detail the angular momentum accumulation history through the gas cooling, merging and star formation processes. Our model successfully reproduces the stellar mass–radius distribution and gas-to-stellar disk size ratio distribution observed locally. We also investigate the dependence of clustering on galaxy size and find qualitative agreement with observation. There is still some discrepancy at small scale for less massive galaxies, indicating that our treatment of satellite galaxies needs to be improved.
Negotiating meaning in cross‐national studies of mathematics teaching: kissing frogs to find princes

This paper outlines the iterative processes by which a multinational team of researchers developed a low‐inference framework for the analysis of video recordings of mathematics lessons drawn from Flemish Belgium, England, Finland, Hungary and Spain. Located within a theoretical framework concerning learning as the negotiation of meaning, we discuss problems of linguistic and conceptual equivalence and the manner by which they were resolved. Significantly, when compared with the time‐stamped codes of projects like the TIMSS video studies, we argue that the unit of analysis adopted, the episode, allowed for the distinctive patterns of a lesson to be retained for comparison with others. Also, we suggest that the framework’s generic, though subject‐focused, codes are amenable to adaptation to other curriculum areas, thus providing an opportunity for the comparative study of subjects not normally associated with work of this nature.
Effectiveness of Environmental Surrogates for the Selection of Conservation Area Networks

Abstract: Rapid biodiversity assessment and conservation planning require the use of easily quantified and estimated surrogates for biodiversity. Using data sets from Québec and Queensland, we applied four methods to assess the extent to which environmental surrogates can represent biodiversity components: (1) surrogacy graphs; (2) marginal representation plots; (3) Hamming distance function; and (4) Syrjala statistical test for spatial congruence. For Québec we used 719 faunal and floral species as biodiversity components, and for Queensland we used 2348 plant species. We used four climatic parameter types (annual mean temperature, minimum temperature during the coldest quarter, maximum temperature during the hottest quarter, and annual precipitation), along with slope, elevation, aspect, and soil types, as environmental surrogates. To study the effect of scale, we analyzed the data at seven spatial scales ranging from 0.01° to 0.10° longitude and latitude. At targeted representations of 10% for environmental surrogates and biodiversity components, all four methods indicated that using a full set of environmental surrogates systematically provided better results than selecting areas at random, usually ensuring that ≥90% of the biodiversity components achieved the 10% targets at scales coarser than 0.02°. The performance of surrogates improved with coarser spatial resolutions. Thus, environmental surrogate sets are useful tools for biodiversity conservation planning. A recommended protocol for the use of such surrogates consists of randomly selecting a set of areas for which distributional data are available, identifying an optimal surrogate set based on these areas, and subsequently prioritizing places for conservation based on the optimal surrogate set.
Hydrogen Oxidation and Evolution Reaction Kinetics on Platinum: Acid vs Alkaline Electrolytes

The kinetics of the hydrogen oxidation reaction (HOR) and hydrogen evolution reaction (HER) on polycrystalline platinum [Pt(pc)] and high surface area carbon-supported platinum nanoparticles (Pt/C) were studied in 0.1 M KOH using rotating disk electrode (RDE) measurements. After corrections of noncompensated solution resistance from ac impedance spectroscopy and of hydrogen mass transport in the HOR branch, the kinetic current densities were fitted to the Butler-Volmer equation using a transfer coefficient of α = 0.5, from which HOR/HER exchange current densities on Pt(pc) and Pt/C were obtained, and the HOR/HER mechanisms in alkaline solution were discussed. Unlike the HOR/HER rates on Pt electrodes in alkaline solution, the HOR/HER rates on a Pt electrode in 0.1 M HClO 4 were limited entirely by hydrogen diffusion, which renders the quantification of the HOR/HER kinetics impossible by conventional RDE measurements. The simulation of the hydrogen anode performance based on the specific exchange current densities of the HOR/HER at 80°C illustrates that in addition to the oxygen reduction reaction cell voltage loss on the cathode, the slow HOR kinetics are projected to cause significant anode potential losses in alkaline fuel cells for low platinum loadings (> 130 mV at 0.05 Mg pt /CM 2 anode and 1.5 A/cm 2 anode ), contrary to what is reported for proton exchange membrane fuel cells.
Human CD8+ T Cells in Asthma: Possible Pathways and Roles for NK-Like Subtypes

Asthma affects approximately 300 million people worldwide and is the most common chronic lung disease, which usually is associated with bronchial inflammation. Most research has focused upon the role of CD4+ T cells, and relatively few studies have addressed the phenotypic and functional roles of CD8+ T cell types and subtypes. Human NK-like CD8+ T cells may involve cells that have been described as CD8+CD28−, CD8+CD28−CD57+, CD8+CD27−, or CD8+ effector memory (TEM) cells, among other. However, most of the data that are available regarding these various cell types were obtained in murine models did not thoroughly characterize these cells with phenotypically or functionally or did not involve asthma-related settings. Nevertheless, one may conceptualize three principal roles for human NK-like CD8+ T cells in asthma: disease-promoting, regulatory, and/or tissue repair. Although evidence for some of these roles is scarce, it is possible to extrapolate some data from overlapping or related CD8+ T cell phenotypes, with caution. Clearly, further research is warranted, namely in terms of thorough functional and phenotypic characterization of human NK-like CD8+ T cells in human asthma of varying severity.
The time of our lives : a critical history of temporality

The project of all philosophy may be to gain reconciliation with time, even if not every philosopher has dealt with time expressly. A confrontation with the passing of time and with human finitude runs through the history of philosophy as an ultimate concern. In this genealogy of the concept of temporality, David Hoy examines the emergence in a post-Kantian continental philosophy of a focus on the lived experience of the "time of our lives" rather than on the time of the universe. The purpose is to see how phenomenological and poststructuralist philosophers have tried to locate the source of temporality, how they have analyzed time's passing, and how they have depicted our relation to time once it has been -- in a Proustian sense -- regained. Hoy engages with competing theoretical tactics for reconciling us to our fleeting temporality, drawing on work by Kant, Heidegger, Hegel, Husserl, Merleau-Ponty, Nietzsche, Gadamer, Sartre, Bourdieu, Foucault, Bergson, Deleuze, Zizek, and Derrida. Hoy considers four existential strategies for coping with the apparent flow of temporality, including Proust's passive and Walter Benjamin's active reconciliation through memory, Zizek's critique of poststructuralist politics, Foucault's confrontation with the temporality of power, and Deleuze's account of Aion and Chronos. He concludes by exploring whether a dual temporalization could be what constitutes the singular "time of our lives. "
Influence of Toxicologically Relevant Metals on Human Epigenetic Regulation

Environmental toxicants such as toxic metals can alter epigenetic regulatory features such as DNA methylation, histone modification, and non-coding RNA expression. Heavy metals influence gene expression by epigenetic mechanisms and by directly binding to various metal response elements in the target gene promoters. Given the role of epigenetic alterations in regulating genes, there is potential for the integration of toxic metal-induced epigenetic alterations as informative factors in the risk assessment process. Here, we focus on recent advances in understanding epigenetic changes, gene expression, and biological effects induced by toxic metals.
The effects of a lower irrigation system on pollutant removal and on the microflora of a biofilter

Moisture control is one the most important parameters in biofilters for air pollution control. Biofilters tend to experience drying at the air inlet port, which causes decreased pollutant removal over time. In this study, the installation of an irrigation system within the lower part of the biofilter bed was proposed, and its effect was quantified in a laboratory scale biofilter operated side by side with a control biofilter. The removal of toluene vapours at short gas residence time (13.5 s) served as a model system. The results showed that the rate of toluene elimination in the biofilter with the lower irrigation system was 1.2–1.7 times greater than the rate of toluene elimination in the control biofilter. At the completion of the two‐month experiment, a detailed examination was conducted of the packing materials with the immobilized pollutant‐degrading culture. The results highlighted the effects of bed drying on cell viability in the control biofilter. They also revealed that the bottom segment of the biofilter with the lower irrigation system had a higher moisture content, a higher biomass density and a larger fraction of active biomass than the corresponding segment in the conventional biofilter. These detailed examinations explained why an increased toluene removal was observed in the system equipped with a lower irrigation system. Overall, this study demonstrates enhanced pollutant removal in biofilters equipped with a lower irrigation system through a better control of moisture.
The Isophotal Structure of Early-Type Galaxies in the SDSS: Dependence on Active Galactic Nucleus Activity and Environment

We study the dependence of the isophotal shape of early-type galaxies on their absolute B-band magnitude, MB, their dynamical mass, Mdyn, and their nuclear activity and environment, using an unprecedented large sample of 847 early-type galaxies identified in SDSS by Hao and colleagues. We find that the fraction of disky galaxies smoothly decreases from fdisky ~ 0.8 at MB - 5 log h = -18.7 (Mdyn = 6 × 1010 h-1 M☉) to ~0.5 at MB - 5 log h = -20.8 (Mdyn = 3 × 1011 h-1 M☉). The large sample allows us to describe these trends accurately with tight linear relations that are statistically robust against the uncertainty in the isophotal shape measurements. There is also a host of significant correlations between fdisky and indicators of nuclear activity (both in the optical and in the radio) and environment (soft X-rays, group mass, and group hierarchy). Our analysis shows, however, that these correlations can be accurately matched by assuming that fdisky only depends on galaxy luminosity or mass. We therefore conclude that neither the level of activity nor the group mass or group hierarchy help in better predicting the isophotal shape of early-type galaxies.
Coeliac screening in a Scottish cohort of children with type 1 diabetes mellitus: is DQ typing the way forward?

Background Children with type 1 diabetes mellitus (T1DM) are at increased risk of coeliac disease (CD). Recent guidelines indicate coeliac screening should include HLA typing for CD predisposing (DQ2/DQ8) alleles and those negative for these alleles require no further coeliac screening. Methods Children (n=176) with T1DM attending clinics across two Scottish regions were screened for HLA DQ2/DQ8 as part of routine screening. Data collected included the frequency of DQ2/DQ8 genotypes and the additional cost of HLA screening. Results Overall, DQ2/DQ8 alleles were identified in 94% of patients. The additional cost of HLA typing was £3699.52 (£21.02 per patient). All patients with known CD (11/176) were positive for DQ2/DQ8 and all were diagnosed with CD within 5 years of T1DM diagnosis. Conclusions The vast majority of children with T1DM have CD-predisposing HLA genotypes limiting the number of patients that can be excluded from further screening. We conclude that HLA genotyping is not currently indicated for CD screening in this population.