Miracle-dz/UniFAR-FTUs huggingface dataset:
Influence of Landscape Structures on Water Quality at Multiple Temporal and Spatial Scales: A Case Study of Wujiang River Watershed in Guizhou

Water quality is highly influenced by the composition and configuration of landscape structure, and regulated by various spatiotemporal factors. Using the Wujiang river watershed as a case study, this research assesses the influence of landscape metrics—including composition and spatial configuration—on river water quality. An understanding of the relationship between landscape metrics and water quality can be used to improve water contamination predictability and provide restoration and management strategies. For this study, eight water quality variables were collected from 32 sampling sites from 2014 through 2017. Water quality variables included nutrient pollutant indicators ammoniacal nitrogen (NH3-N), nitrogen (NO3−), and total phosphate (TP), as well as oxygen-consuming organic matter indicators COD (chemical oxygen demand), biochemical oxygen demand (BOD5), dissolved oxygen (DO), and potassium permanganate index (CODMn). Partial least squares (PLS) regression was used to quantitatively analyze the influence of landscape metrics on water quality at five buffer zone scales (extending 3, 6, 9, 12, and 15 km from the sample site) in the Wujiang river watershed. Results revealed that water quality is affected by landscape composition, landscape configuration, and precipitation. During the dry season, landscape metrics at both landscape and class levels predicted organic matter at the five buffer zone scales. During the wet season, only class-level landscape metrics predicted water contaminants, including organic matter and nutrients, at the middle three of five buffer scales. We identified the following important indicators of water quality degradation: percent of landscape, edge density, and aggregation index for built-up land; aggregation index for water; CONTAGION; COHESION; and landscape shape index. These results suggest that pollution can be mitigated by reducing natural landscape composition fragmentation, increasing the connectedness of region rivers, and minimizing human disturbance of landscape structures in the watershed area.
Staleness-Aware Async-SGD for Distributed Deep Learning

Deep neural networks have been shown to achieve state-of-the-art performance in several machine learning tasks. Stochastic Gradient Descent (SGD) is the preferred optimization algorithm for training these networks and asynchronous SGD (ASGD) has been widely adopted for accelerating the training of large-scale deep networks in a distributed computing environment. However, in practice it is quite challenging to tune the training hyperparameters (such as learning rate) when using ASGD so as achieve convergence and linear speedup, since the stability of the optimization algorithm is strongly influenced by the asynchronous nature of parameter updates. In this paper, we propose a variant of the ASGD algorithm in which the learning rate is modulated according to the gradient staleness and provide theoretical guarantees for convergence of this algorithm. Experimental verification is performed on commonly-used image classification benchmarks: CIFAR10 and Imagenet to demonstrate the superior effectiveness of the proposed approach, compared to SSGD (Synchronous SGD) and the conventional ASGD algorithm.
The Philadelphia story.

A coordinator of the Delaware Valley Ethics Committee Network (DVECN) reports on DVECN's project to develop Sample Policy Packets. These packets, researched and put together by DVECN's Policies and Research Subcommittee, are designed to provide an educational resource for members whose hospital ethics committees have been charged with writing or revising institutional policies on specific topics. Each packet contains several sample policies, a cover sheet that highlights important issues, and a list of references. Packets have been issued on withholding/withdrawing treatment, do-not-resuscitate orders, organ donation, and HIV infection.
Do common symptoms in women predict long spells of sickness absence? A prospective community-based study on Swedish women 40 to 50 years of age

Aims: To investigate whether a high level of commonly experienced physical and mental symptoms could predict long spells of sickness absence in Swedish women and, further, to investigate the causal pattern of socioeconomic and psychosocial factors in relation to long spells of sickness absence. Methods: A questionnaire containing items on socioeconomic and psychosocial variables was sent to a random population of women, 40 to 50 years of age, living in a rural Swedish community. The response rate was 81.7% (397 women). Data on long spells of sickness absence (> 14 days) for the year following the baseline survey were obtained from the social insurance office. Odds ratios (OR) were used to estimate bivariate associations. Multiple logistic regression analysis was used to test for confounding and effect modification. Results: Women suffering from a high level of common symptoms were at risk of subsequent long spells of sickness absence, OR = 3.39 (1.86-6.17). High demands at work and an active job position (i.e. the combination of high demands and a high degree of job control) were both associated with long spells of sickness absence, OR = 2.16 (1.12-4.17) and OR=1.92 (1.01-3.67). The combined exposure (high level of common symptoms and an active job position) increased the odds for long spells of sickness absence (OR = 9.13; 3.39-24.58) with synergy noted. Conclusions: The finding that women with common symptoms are at risk of future sickness absence is of particular importance in a primary health care setting. The finding that women in active job positions had a higher risk of sickness absence might be an effect of modern working conditions for women.
Bag-of-visual-words and spatial extensions for land-use classification

We investigate bag-of-visual-words (BOVW) approaches to land-use classification in high-resolution overhead imagery. We consider a standard non-spatial representation in which the frequencies but not the locations of quantized image features are used to discriminate between classes analogous to how words are used for text document classification without regard to their order of occurrence. We also consider two spatial extensions, the established spatial pyramid match kernel which considers the absolute spatial arrangement of the image features, as well as a novel method which we term the spatial co-occurrence kernel that considers the relative arrangement. These extensions are motivated by the importance of spatial structure in geographic data. The methods are evaluated using a large ground truth image dataset of 21 land-use classes. In addition to comparisons with standard approaches, we perform extensive evaluation of different configurations such as the size of the visual dictionaries used to derive the BOVW representations and the scale at which the spatial relationships are considered. We show that even though BOVW approaches do not necessarily perform better than the best standard approaches overall, they represent a robust alternative that is more effective for certain land-use classes. We also show that extending the BOVW approach with our proposed spatial co-occurrence kernel consistently improves performance.
Efficacy and safety of ferrous asparto glycinate in the management of iron deficiency anaemia in pregnant women

Abstract The aim of the present investigation was to compare the efficacy and safety of oral ferrous asparto glycinate and ferrous ascorbate in pregnant women with iron deficiency anaemia (IDA). We performed a double blind, prospective, randomised, multicentre, parallel group comparative clinical study at three different centres in India. A total of 73 pregnant women at 12–26 weeks’ gestation were divided into two arms. While one group received ferrous ascorbate, another group was treated with ferrous asparto glycinate for a period of 28 days. The mean rise in haemoglobin and ferritin levels on day 14 and 28 was evaluated. At both time points, significantly higher levels of haemoglobin and ferritin were noticed with ferrous asparto glycinate treatment as compared with ferrous ascorbate. Our results showed that ferrous asparto glycinate is an effective iron–amino acid chelate in the management of IDA in pregnant women as compared with ferrous ascorbate. Nevertheless, additional large scale prospective, randomised trials are warranted to confirm the findings of the present efficacy trial, and also to find out the anaemia eradication rate.
Whole packet forwarding: Efficient design of fully adaptive routing algorithms for networks-on-chip

Routing algorithms for networks-on-chip (NoCs) typically only have a small number of virtual channels (VCs) at their disposal. Limited VCs pose several challenges to the design of fully adaptive routing algorithms. First, fully adaptive routing algorithms based on previous deadlock-avoidance theories require a conservative VC re-allocation scheme: a VC can only be re-allocated when it is empty, which limits performance. We propose a novel VC re-allocation scheme, whole packet forwarding (WPF), which allows a non-empty VC to be re-allocated. WPF leverages the observation that the majority of packets in NoCs are short. We prove that WPF does not induce deadlock if the routing algorithm is deadlock-free using conservative VC re-allocation. WPF is an important extension of previous deadlock-avoidance theories. Second, to efficiently utilize WPF in VC-limited networks, we design a novel fully adaptive routing algorithm which maintains packet adaptivity without significant hardware cost. Compared with conservative VC re-allocation, WPF achieves an average 88.9% saturation throughput improvement in synthetic traffic patterns and an average 21.3% and maximal 37.8% speedup for PARSEC applications with heavy network loads. Our design also offers higher performance than several partially adaptive and deterministic routing algorithms.
Intracoronary Compared With Intravenous Bolus Abciximab Application in Patients With ST-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention: The Randomized Leipzig Immediate Percutaneous Coronary Intervention Abciximab IV Versus IC in ST-Elevation Myocardial Infarct

Background— Abciximab reduces major adverse cardiac events in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention (PCI). Intracoronary abciximab bolus application results in high local drug concentrations and may be more effective than a standard intravenous bolus. Methods and Results— Patients undergoing primary PCI were randomized to either intracoronary (n=77) or intravenous (n=77) bolus abciximab administration with subsequent 12-hour intravenous infusion. The primary end point was infarct size and extent of microvascular obstruction as assessed by delayed enhancement magnetic resonance. Secondary end points were ST-segment resolution at 90 minutes, Thrombolysis in Myocardial Infarction flow and perfusion grades after PCI, and the occurrence of major adverse cardiac events within 30 days. The median infarct size was 15.1% (interquartile range, 6.1% to 25.2%) in the intracoronary versus 23.4% (interquartile range, 13.6% to 33.2%) in the intravenous group (P=0.01). Similarly, the extent of microvascular obstruction was significantly smaller in intracoronary compared with intravenous abciximab patients (P=0.01). Myocardial perfusion measured as early ST-segment resolution was significantly improved in intracoronary patients with an absolute ST-segment resolution of 77.8% (interquartile range, 66.7% to 100.0%) versus 70.0% (interquartile range, 45.2% to 83.5%; P=0.006). The Thrombolysis in Myocardial Infarction flow after PCI was not different between treatment groups (P=0.51), but there was a trend toward an improved perfusion grade (P=0.09). There also was a trend toward a lower major adverse cardiac event rate after intracoronary versus intravenous abciximab application (5.2% versus 15.6%; P=0.06; relative risk, 0.33; 95% CI, 0.09 to 1.05). Conclusions— Intracoronary bolus administration of abciximab in primary PCI is superior to standard intravenous treatment with respect to infarct size, extent of microvascular obstruction, and perfusion.
A Tri-Oceanic Perspective: DNA Barcoding Reveals Geographic Structure and Cryptic Diversity in Canadian Polychaetes

Background Although polychaetes are one of the dominant taxa in marine communities, their distributions and taxonomic diversity are poorly understood. Recent studies have shown that many species thought to have broad distributions are actually a complex of allied species. In Canada, 12% of polychaete species are thought to occur in Atlantic, Arctic, and Pacific Oceans, but the extent of gene flow among their populations has not been tested. Methodology/Principal Findings Sequence variation in a segment of the mitochondrial cytochrome c oxidase I (COI) gene was employed to compare morphological versus molecular diversity estimates, to examine gene flow among populations of widespread species, and to explore connectivity patterns among Canada's three oceans. Analysis of 1876 specimens, representing 333 provisional species, revealed 40 times more sequence divergence between than within species (16.5% versus 0.38%). Genetic data suggest that one quarter of previously recognized species actually include two or more divergent lineages, indicating that richness in this region is currently underestimated. Few species with a tri-oceanic distribution showed genetic cohesion. Instead, large genetic breaks occur between Pacific and Atlantic-Arctic lineages, suggesting their long-term separation. High connectivity among Arctic and Atlantic regions and low connectivity with the Pacific further supports the conclusion that Canadian polychaetes are partitioned into two distinct faunas. Conclusions/Significance Results of this study confirm that COI sequences are an effective tool for species identification in polychaetes, and suggest that DNA barcoding will aid the recognition of species overlooked by the current taxonomic system. The consistent geographic structuring within presumed widespread species suggests that historical range fragmentation during the Pleistocene ultimately increased Canadian polychaete diversity and that the coastal British Columbia fauna played a minor role in Arctic recolonization following deglaciation. This study highlights the value of DNA barcoding for providing rapid insights into species distributions and biogeographic patterns in understudied groups.
Separate and concurrent symbolic predictions of sound features are processed differently

The studies investigated the impact of predictive visual information about the pitch and location of a forthcoming sound on the sound processing. In Symbol-to-Sound matching paradigms, symbols induced predictions of particular sounds. The brain's error signals (IR and N2b components of the event-related potential) were measured in response to occasional violations of the prediction, i.e., when a sound was incongruent to the corresponding symbol. IR and N2b index the detection of prediction violations at different levels, IR at a sensory and N2b at a cognitive level. Participants evaluated the congruency between prediction and actual sound by button press. When the prediction referred to only the pitch or only the location feature (Experiment 1), the violation of each feature elicited IR and N2b. The IRs to pitch and location violations revealed differences in the in time course and topography, suggesting that they were generated in feature-specific sensory areas. When the prediction referred to both features concurrently (Experiment 2), that is, the symbol predicted the sound's pitch and location, either one or both predictions were violated. Unexpectedly, no significant effects in the IR range were obtained. However, N2b was elicited in response to all violations. N2b in response to concurrent violations of pitch and location had a shorter latency. We conclude that associative predictions can be established by arbitrary rule-based symbols and for different sound features, and that concurrent violations are processed in parallel. In complex situations as in Experiment 2, capacity limitations appear to affect processing in a hierarchical manner. While predictions were presumably not reliably established at sensory levels (absence of IR), they were established at more cognitive levels, where sounds are represented categorially (presence of N2b).
Validation of physiological scoring systems in the accident and emergency department

Background: Scoring systems that weigh the degree of abnormality of bedside observations might be able to identify patients at risk of catastrophic deterioration. Objectives: To establish a frequency distribution for typical physiological scoring systems and to establish the potential benefit of adding these to an existing triage system in accident and emergency departments. Methods: Physiological data were collected from 53 unselected emergency department admissions, from 50 patients admitted from the emergency department to intensive care, and from 50 patients admitted from emergency department to general wards and then to intensive care. Three different physiological scores were calculated from the data. Identification of sick patients by the scores was compared with triage information from the Manchester Triage System (MTS). Results: Most patients admitted to the emergency department would not be identified as critically ill with the aid of physiological scoring systems. This was true even for patients who were admitted to intensive care. Only in 0–8% of unselected patients did the scores indicate increased risk. In 100 patients admitted to the intensive care, adding of medical emergency team call-out criteria, Modified Early Warning Score or Assessment Score for Sick patient Identification and Step-up in Treatment would identify none, seven or one patient in addition to those triaged as orange and red by the MTS. Conclusions: Introduction of a physiological scoring system would have identified only a small number of additional patients as critically ill and added little to the triage system currently in use.
Efficacy of two compression systems in the management of VLUs: results of a European RCT.

OBJECTIVE To evaluate the efficacy, tolerance and acceptability an innovative two-layer system (KTwo; Laboratoires URGO) versus an established four-layer bandage system (Profore; Smith & Nephew) in the local management of venous leg ulcers. METHOD A non-inferiority European randomised controlled trial, conducted in 37 centres, in three countries (France, U.K. and Germany), on patients presenting with venous leg ulcers (VLUs). Participants were adult, non-immunosuppressed patients who presented with non-infected, non-malignant leg ulcers, predominantly of venous origin (ABPI > 0.8), with a surface area of 2-50 cm2 and duration 1-24 months. Patients were followed-up every 2 weeks for a period of 12 weeks, or until full closure. Visits included a clinical examination, wound area tracings and photographic evidence. The primary endpoint was the percentage of leg ulcers healed after the 12 weeks, with secondary endpoints of relative wound area reduction (RWAR), absolute wound area reduction (AWAR) and the percentage of wounds with RWAR > or = 40%. RESULTS In total, 187 patients were randomised to either the two-layer bandage (2LB, n=94) or four-layer bandage (4LB; n=93) system. The two groups were comparable,with regard to wound and patient characteristics, at baseline. By week 12, 44% of VLUs in the 2LB group and 39% in the 4LB group had healed (intention-to-treat [ITT] analysis). The per-protocol (PP) analysis showed that complete wound closure was obtained in 48% and 38% of the 2LB and 4LB groups, respectively. A non-inferiority margin within -10% is considered as demonstrating a 95% and 97.5% confidence interval (p = 0.001). The AWAR was 6.6 cm2 in the test and 4.9 cm2 in the control group. The percentage of wounds with a RWAR > OR =40% was 47% and 44% for the 2LB and 4LB systems, respectively. Pain between dressing changes was reported in 27% of the test and 40% of the control group, and the incidence of adverse events was 17% and 25%, respectively. The 2LB compression system was considered to be significantly easier to apply than the 4LB (p = 0.038). CONCLUSION The 2LB system (KTwo) was not seen to be any less effective than a well-known 4LB system (Profore) in the management of VLUs. Furthermore, the 2LB system was considered to be easier to apply, representing an alternative to the conventional treatment with 4LB currently available. DECLARATION OF INTEREST This study was sponsored by a grant from Laboratoires URGO, manufacturers of KTwo. S. Bohbot and A. Sauvadet are employees of Laboratoires Urgo. S. Meaume has received monetary compensation as a speaker for Laboratoires Urgo. Data management and statistical analyses were conducted by Vertical (J. C. Kerihuel; Paris, France).
Towards a Declarative Language and System for Secure Networking

In this paper, we present a declarative language and system for describing and implementing secure networks. Our proposed language, SeNDlog, is an attempt at unifying Binder, a logic-based language for access control in distributed systems, and Network Datalog (NDlog), a database query language for declarative networks. The contributions of this paper are as follows. First, we highlight the similarities and differences between Binder and NDlog with regards to their notion of location, trust model, and evaluation strategies. Second, we motivate and propose the SeNDlog language that combines features from Binder and NDlog. Third, we demonstrate the use of SeNDlog for specifying secure networks and present directions for future work.
Role of the Lymphotoxin/LIGHT System in the Development and Maintenance of Reticular Networks and Vasculature in Lymphoid Tissues

Lymphoid organs are meeting zones where lymphocytes come together and encounter antigens present in the blood and lymph or as delivered by cells migrating from the draining tissue bed. The exquisite efficiency of this process relies heavily on highly specialized anatomy to direct and position the various players. Gated entry and exit control access to these theaters and reticular networks and associated chemokines guide cells into the proper sections. Lymphoid tissues are remarkably plastic, being able to expand dramatically and then involute upon resolution of the danger. All of the reticular scaffolds and vascular and lymphatic components adapt accordingly. As such, the lymph node (LN) is a wonderful example of a physiologic remodeling process and is potentially a guide to study such elements in pathological settings such as fibrosis, chronic infection, and tumor metastasis. The lymphotoxin/LIGHT axis delivers critical differentiation signals that direct and hone differentiation of both reticular networks and the vasculature. Considerable progress has been made recently in understanding the mesenchymal differentiation pathways leading to these specialized networks and in the remodeling that occurs in reactive LNs. In this article, we will review some new advances in the area in terms of developmental, differentiation, and maintenance events mediated by this axis.