Miracle-dz/UniFAR-FTUs huggingface dataset:
Efficacy of cardiac resynchronization with defibrillator insertion in patients undergone coronary artery bypass graft: A cohort study of cardiac function

Introduction: Cardiac resynchronization therapy (CRT) is a proven therapeutic method in selected patients with heart failure and systolic dysfunction which increases left ventricular function and patient survival. We designed a study that included patients undergoing coronary artery bypass graft (CABG), with and without CRT-defibrillator (CRT-D) inserting and then measured its effects on these two groups. Patients and Methods: Between 2010 and 2013, we conducted a prospective cohort study on 100 coronary artery disease patients where candidate for CABG. Then based on the receiving CRT-D, the patients were categorized in two groups; Group 1 (n = 48, with CRT-D insertion before CABG) and Group 2 (n = 52 without receiving CRT-D). Thereafter both of these groups were followed-up at 1–3 months after CABG for mortality, hospitalization, atrial fibrillation (AF), echocardiographic assessment, and New York Heart Association (NYHA) class level. Results: The mean age of participants in Group 1 (48 male) and in Group 2 (52 male) was 58 ± 13 and 57 ± 12 respectively. Difference between Groups 1 and 2 in cases of mean left ventricular ejection fraction (LVEF) changes and NYHA class level was significant (P > 0.05). Hospitalization (P = 0.008), mortality rate (P = 0.007), and AF were significantly different between these two groups. Conclusions: The results showed that the increase in LVEF and patient's improvement according to NYHA-class was significant in the first group, and readmission, mortality rate and AF was increased significantly in the second group.
The Global Networks of Multinational Firms

In this paper we characterize the topology of global multinational networks and examine the macro and micro patterns of multinational activity. We construct indices of network density at both pairwise industry and establishment level and measure agglomeration in a global and continuous metric space. These indices exhibit distinct advantages compared to traditional measures of agglomeration including the independence on the level of geographic aggregation. Estimating the indices using a new worldwide establishment dataset, we investigate both the signi cance and causes of multinational rm co-agglomeration. In contrast to the conventional emphasis of the literature on the role of input-output linkages, we assess the e¤ect of various agglomeration economies. We nd that, relative to counterfactuals, multinationals with greater factor-market externalities, knowledge spillovers, and vertical linkages exhibit signi cant co-agglomeration. The importance of these factors di¤ers across headquarters, subsidiary, and employment networks, but knowledge spillovers and capital-market externalities, two traditionally under-emphasized forces, exert consistently strong e¤ects. Within each macro network, there is a large heterogeneity across subsidiaries. Subsidiaries with greater size and higher productivity attract signi cantly more agglomeration than their counterfactuals and become the hubs of the network. JEL codes: F2, D2, R1, R3 Key words: multinational rm, agglomeration, network, input-output linkage, knowledge spillover, factor market externality We thank Jim Anderson, Bruce Blonigen, Tarun Khanna, Keith Maskus, Mike Moore, John Ries, Stephen Yeaple, Tony Yezer, and participants in the ETSG plenary session, EIIT meeting and GW seminar for helpful comments and suggestions. We also thank William Kerr for kindly providing us the patent concordance data, Bill Simpson for excellent advice in calculating the agglomeration index, and Francisco Pino for help with the GIS software. We are grateful to Dun & Bradstreet and Dennis Jacques for helping us with the D&B data set and HBS and GW for nancial support. yEmail: lalfaro@hbs.edu; Phone: 617-495-7981. zEmail: xchen@gwu.edu; Phone: 202-994-0192.
A Single Methylene Group in Oligoalkylamine-Based Cationic Polymers and Lipids Promotes Enhanced mRNA Delivery.

The development of chemically modified mRNA holds great promise as a new class of biologic therapeutics. However, the intracellular delivery and endosomal escape of mRNA encapsulated in nanoparticles has not been systematically investigated. Here, we synthesized a diverse set of cationic polymers and lipids from a series of oligoalkylamines and subsequently characterized their mRNA delivery capability. Notably, a structure with an alternating alkyl chain length between amines showed the highest transfection efficiency, which was linked to a high buffering capacity in a narrow range of pH 6.2 to 6.5. Variation in only one methylene group resulted in enhanced mRNA delivery to both the murine liver as well as porcine lungs after systemic or aerosol administration, respectively. These findings reveal a novel fundamental structure-activity relationship for the delivery of mRNA that is independent of the class of mRNA carrier and define a promising new path of exploration in the field of mRNA therapeutics.
Modal Analysis of a Single-Structure Multiaxis MEMS Gyroscope

This paper reports on designing a single-structure triaxes MEMS capacitive gyroscope which is capable of measuring the three angular velocities on a single drive. A Z-shaped beam for the support of folded coupling spring has been applied to suppress the unwanted mode and decrease the stress effect at the spring ends. The unique coupling spring has changed the driving motion, due to which slide film damping in the driving mode has been reduced. This reduction can lead to higher performance of the sensor with less requirements on vacuum level which decreases the cost of fabrication. Simulation analysis has been performed in COMSOL Multiphysics and Matlab Simulink to finalize the design for fabrication. After finite element analysis, the driving, -sensing, -sensing, and -sensing are, respectively, found to be 13.30 KHz, 13.40 KHz, 13.47 KHz, and 13.51 KHz.
Improvement of quality of life in patients surgically treated for asymptomatic unruptured intracranial aneurysms

Objective: To compare the preoperative and postoperative health-related quality of life (QOL) and psychological state of patients with asymptomatic unruptured intracranial aneurysms (ICAs) who underwent elective surgery. Methods: Out of 67 patients who underwent neck clipping of ICAs, we assessed the QOL of 61 patients using Short Form-36 (SF-36); their psychological state was rated on the Hospital Anxiety and Depression Scale (HADS) before, 3 months, and 1 and 3 years after treatment. Results: The preoperative mean scores for each of the eight SF-36 domains except bodily pain were significantly lower in the study population than in the reference population. 14 (20.9%) patients experienced surgical complications defined as neurological deterioration and/or abnormal CT findings within 30 days of the operation. Despite some complications, the QOL of all operated patients returned to the mean level of the reference population 3 years after treatment. At 3 months after surgery, the scores for psychosocial activities and general health perception were transiently below the preoperative levels. According to the HADS, the patients experienced mild anxiety before the operation; it disappeared by the third postoperative month. Conclusions: Preoperatively, patients with unruptured ICAs reported a significantly decreased QOL. It further declined transiently after elective surgery, but it returned to the mean level recorded for the reference population within 3 years. Our findings suggest that these patients derived significant QOL benefits from their surgery. Hence subjective QOL issues should be considered in deciding whether treatment-related risks and their natural history, such as their potential rupture, warrant surgery of asymptomatic unruptured ICAs.
Auxin and Ethylene Induce Flavonol Accumulation through Distinct Transcriptional Networks1[C][W][OA]

Auxin and ethylene are key regulators of plant growth and development, and thus the transcriptional networks that mediate responses to these hormones have been the subject of intense research. This study dissected the hormonal cross talk regulating the synthesis of flavonols and examined their impact on root growth and development. We analyzed the effects of auxin and an ethylene precursor on roots of wild-type and hormone-insensitive Arabidopsis (Arabidopsis thaliana) mutants at the transcript, protein, and metabolite levels at high spatial and temporal resolution. Indole-3-acetic acid (IAA) and 1-aminocyclopropane-1-carboxylic acid (ACC) differentially increased flavonol pathway transcripts and flavonol accumulation, altering the relative abundance of quercetin and kaempferol. The IAA, but not ACC, response is lost in the transport inhibitor response1 (tir1) auxin receptor mutant, while ACC responses, but not IAA responses, are lost in ethylene insensitive2 (ein2) and ethylene resistant1 (etr1) ethylene signaling mutants. A kinetic analysis identified increases in transcripts encoding the transcriptional regulators MYB12, Transparent Testa Glabra1, and Production of Anthocyanin Pigment after hormone treatments, which preceded increases in transcripts encoding flavonoid biosynthetic enzymes. In addition, myb12 mutants were insensitive to the effects of auxin and ethylene on flavonol metabolism. The equivalent phenotypes for transparent testa4 (tt4), which makes no flavonols, and tt7, which makes kaempferol but not quercetin, showed that quercetin derivatives are the inhibitors of basipetal root auxin transport, gravitropism, and elongation growth. Collectively, these experiments demonstrate that auxin and ethylene regulate flavonol biosynthesis through distinct signaling networks involving TIR1 and EIN2/ETR1, respectively, both of which converge on MYB12. This study also provides new evidence that quercetin is the flavonol that modulates basipetal auxin transport.
Institutional Governance of Minority Religious Practices: Insights from a Study of Muslim Practices in Danish Schools

ABSTRACT An increasing number of studies are concerned with the ways in which the religious practices of Europe's minority populations are accommodated on the political, national and local levels. In this article, I present a case study of Muslim practices in Danish schools. The study is an investigation of how and why six selected practices are governed in Danish schools: halal food, fasting, prayer, head scarves, holidays and mosques. The results underline the importance of the specific practice in question for the way in which it is governed: some practices are easily accommodated, while others are rejected outright by the schools. Furthermore, the study demonstrates how governance of Muslim practices is developed in the absence of national regulation and against the prevailing ideals in the Danish public debate. In fact, the governance developed seems to be a direct response to the number of Muslim children in school and in line with general school ideals of inclusion. However, the results also indicate that more direct involvement by local or national authorities might push schools to be more exclusive with regard to Muslim practices.
HABITS AND ATTITUDES OF MOTHERS OF INFANTS IN RELATION TO BREASTFEEDING AND ARTIFICIAL FEEDING IN 11 BRAZILIAN CITIES

ABSTRACT Objective: To analyze the relationship between habits and attitudes of mothers and the types of milk offered to their children in their first two years of life. Methods: Retrospective study including 773 interviews of mothers from 11 Brazilian cities with children under 2 years of age. Interviews were conducted in 11 cities of Brazil. The following factors were analyzed: breastfeeding method planned during pregnancy and the method actually applied after birth; type(s) of milk(s) used on the day of the interview and earlier; age at which the child was introduced to whole milk; and source of advice used to choose a certain type of milk. Results: Breast milk was offered to 81.7% of infants during their first six months of life, to 52.2% of infants during their second semester (p<0.001) and to 32.9% of infants during their second year of life (p<0.001). In contrast, cow’s milk consumption increased from 31.1 to 83.8% (p<0.001) and 98.7% (p=0.05), respectively, for these three age groups. Infant (15.0%) and follow-on (also known as toddler’s) (2.3%) formulas were used by a much smaller number of infants than whole cow’s milk. Most mothers were not prescribed whole cow’s milk. Pediatricians were the health care professionals who most often recommended infant formulas. Conclusions: Rates of breastfeeding in Brazil remain below recommended levels. Brazilian mothers often decide to feed their infants with whole cow’s milk on their own initiative. The use of infant formulas after weaning is still too low.
Stabilization of a System of  $n+1$ Coupled First-Order Hyperbolic Linear PDEs With a Single Boundary Input

We solve the problem of stabilization of a class of linear first-order hyperbolic systems featuring n rightward convecting transport PDEs and one leftward convecting transport PDE. We design a controller, which requires a single control input applied on the leftward convecting PDE's right boundary, and an observer, which employs a single sensor on the same PDE's left boundary. We prove exponential stability of the origin of the resulting plant-observer-controller system in the spatial L2-sense.
Type-1 metabotropic glutamate receptor signaling in cerebellar Purkinje cells in health and disease

The cerebellum is a brain structure involved in coordination, control, and learning of movements, as well as certain aspects of cognitive function. Purkinje cells are the sole output neurons from the cerebellar cortex and therefore play crucial roles in the overall function of the cerebellum. The type-1 metabotropic glutamate receptor (mGluR1) is a key “hub” molecule that is critically involved in the regulation of synaptic wiring, excitability, synaptic response, and synaptic plasticity of Purkinje cells. In this review, we aim to highlight how mGluR1 controls these events in Purkinje cells. We also describe emerging evidence that altered mGluR1 signaling in Purkinje cells underlies cerebellar dysfunctions in several clinically relevant mouse models of human ataxias.
Negative Controls: A Tool for Detecting Confounding and Bias in Observational Studies

Noncausal associations between exposures and outcomes are a threat to validity of causal inference in observational studies. Many techniques have been developed for study design and analysis to identify and eliminate such errors. Such problems are not expected to compromise experimental studies, where careful standardization of conditions (for laboratory work) and randomization (for population studies) should, if applied properly, eliminate most such noncausal associations. We argue, however, that a routine precaution taken in the design of biologic laboratory experiments—the use of “negative controls”—is designed to detect both suspected and unsuspected sources of spurious causal inference. In epidemiology, analogous negative controls help to identify and resolve confounding as well as other sources of error, including recall bias or analytic flaws. We distinguish 2 types of negative controls (exposure controls and outcome controls), describe examples of each type from the epidemiologic literature, and identify the conditions for the use of such negative controls to detect confounding. We conclude that negative controls should be more commonly employed in observational studies, and that additional work is needed to specify the conditions under which negative controls will be sensitive detectors of other sources of error in observational studies.
Neural Machine Translation with Supervised Attention

The attention mechanism is appealing for neural machine translation, since it is able to dynamically encode a source sentence by generating a alignment between a target word and source words. Unfortunately, it has been proved to be worse than conventional alignment models in alignment accuracy. In this paper, we analyze and explain this issue from the point view of reordering, and propose a supervised attention which is learned with guidance from conventional alignment models. Experiments on two Chinese-to-English translation tasks show that the supervised attention mechanism yields better alignments leading to substantial gains over the standard attention based NMT.
Treatment of autoimmune hemolytic anemias

Autoimmune hemolytic anemia (AIHA) is a relatively uncommon disorder caused by autoantibodies directed against self red blood cells. It can be idiopathic or secondary, and classified as warm, cold (cold hemagglutinin disease (CAD) and paroxysmal cold hemoglobinuria) or mixed, according to the thermal range of the autoantibody. AIHA may develop gradually, or have a fulminant onset with life-threatening anemia. The treatment of AIHA is still not evidence-based. The first-line therapy for warm AIHA are corticosteroids, which are effective in 70–85% of patients and should be slowly tapered over a time period of 6–12 months. For refractory/relapsed cases, the current sequence of second-line therapy is splenectomy (effective approx. in 2 out of 3 cases but with a presumed cure rate of up to 20%), rituximab (effective in approx. 80–90% of cases), and thereafter any of the immunosuppressive drugs (azathioprine, cyclophosphamide, cyclosporin, mycophenolate mofetil). Additional therapies are intravenous immunoglobulins, danazol, plasma-exchange, and alemtuzumab and high-dose cyclophosphamide as last resort option. As the experience with rituximab evolves, it is likely that this drug will be located at an earlier point in therapy of warm AIHA, before more toxic immunosuppressants, and in place of splenectomy in some cases. In CAD, rituximab is now recommended as first-line treatment.
A Perspective on Police Professionalization

In the reform literature on the police, ranging from Hopkins' Our Lawless Police and the Wickersham Commission Reports in the 1930s to the Presidential Commissions of the 1960s,l the argument has always been made that effective police reform waits upon professionalization. It is implied that better personnel, with better training, will provide better performance of police tasks. The recruitment and training proposals that are offered suggest that criteria such as a college degree are necessary in order to encourage adherence to "high professional standards of law enforcement. "2 Few have challenged3 the implicit assumption that professionalization is indeed efficacious, despite the fact that clear evidence of better performance has never been offered.
HIV/STD Knowledge, Attitudes, and Risk Behaviors in Hmong-American Adolescents: An Unstudied Population

This is the first study of HIV / STD knowledge, attitudes, and risk behaviors in the Hmong-American community. This exploratory study describes the self-reported HIV / STD knowledge, attitudes, and risk behaviors of 299 Hmong-American 7th - 12th grade students in nine public junior and senior high schools using bilingual questionnaires. Findings supported our hypotheses that Hmong-American adolescents had relatively low levels of risky behaviors, were significantly less likely to answer HIV / STD culturally specific knowledge and attitude items correctly than general knowledge and attitude items, and that their level of acculturation was positively related to their HIV / STD knowledge and attitudes. In addition, we found that Hmong-American adolescents had higher levels of knowledge about HIV/STD and more desirable attitudes toward HIV / STD than originally predicted. Finally, we found that the age, grade, sex, and marital status of the Hmong adolescents in our study were significantly related to either t.
Is Reliability Compromised Towards the End of Long Personality Inventories?

During very long self-rating sessions there is a risk that respondents will be tired and/or lose interest. Is this a concern for users of long personality inventories, such that the reliability becomes threatened in the latter half when respondents have made hundreds of personality self-ratings? Two thousand three hundred fifty-two volunteers completed long (≈ 500 items) personality inventories on the Internet, where items were presented in a unique random order for each participant. Perhaps counterintuitively, there was no evidence that reliability is threatened as respondents approach the end of a long personality inventory. If anything, the ratings in the second half of the inventories had higher reliability than ratings in the first half. Ratings were quicker towards the end of the inventories, but equally reliable. The criterion validity, estimated using Paunonen’s Behavior Report Form, was maintained too. The current results provide little reason to mistrust responses to items that appear towards the end of long personality inventories.
Voluntary association involvement and trust: addressing the causal relationship

In recent years, research has come to focus on the empirical relationship between trust and voluntary association involvement within social capital literature. Scholars have explored the question of whether trust can be implicated as a cause, or as an effect of voluntary association involvement. In the same way, others have found evidence to support the claim that voluntary association involvement leads to increased levels of trust. The focus of this study is to examine the relationship and causal direction, if any, between trust and voluntary association involvement, using longitudinal data from the British Household Panel Survey (BHPS) 1990 through to 2004. Findings indicate that a reciprocal relationship exists between trust and voluntary association involvement. Results show that voluntary association involvement leads to an increased sense of trustworthiness of others. At the same time, causal links from generalized trust to voluntary association involvement were found to be significant. In addition, findings also suggest that type of voluntary association is a significant factor in the relationship between trust and voluntary association involvement.