Miracle-dz/UniFAR-FTUs huggingface dataset:
A 58.6mW 30fps Real-Time Programmable Multi-Object Detection Accelerator with Deformable Parts Models on Full HD 1920×1080 Videos

This paper presents a programmable, energyefficient and real-time object detection hardware accelerator for low power and high throughput applications using deformable parts models, with 2× higher detection accuracy than traditional rigid body models. Three methods are used to address the high computational complexity of 8 deformable parts detection: classification pruning for 33× fewer part classification, vector quantization for 15× memory size reduction, and feature basis projection for 2× reduction in the cost of each classification. The chip was fabricated in a 65nm CMOS technology, and can process full high definition 1920×1080 videos at 60fps without any off-chip storage. The chip has two programmable classification engines for multi-object detection. At 30fps, the chip consumes only 58.6mW (0.94 nJ/pixel, 1168 GOPS/W). At a higher throughput of 60fps, the classification engines can be time multiplexed to detect even more than two object classes. This proposed accelerator enables object detection to be as energyefficient as video compression, which is found in most cameras today. Keywords—Deformable parts, object detection, basis projection, pruning.
Radial Bragg laser as a miniaturized rotation sensor

We present and study theoretically a novel approach for rotation sensing by utilizing radial Bragg lasers (RBL) as a miniaturized optical Gyro. We study the dynamics and steady state of the electric fields evolving in the RBLs under rotation. We show that by utilizing the properties of the steady-state field profile of the RBL rather than a direct measurement of the Sagnac frequency-shift, it is possible to increase significantly the sensitivity for slow rotation rates.
Regulation of Seed Germination in the Close Arabidopsis Relative Lepidium sativum: A Global Tissue-Specific Transcript Analysis1[C][W][OA]

The completion of germination in Lepidium sativum and other endospermic seeds (e.g. Arabidopsis [Arabidopsis thaliana]) is regulated by two opposing forces, the growth potential of the radicle (RAD) and the resistance to this growth from the micropylar endosperm cap (CAP) surrounding it. We show by puncture force measurement that the CAP progressively weakens during germination, and we have conducted a time-course transcript analysis of RAD and CAP tissues throughout this process. We have also used specific inhibitors to investigate the importance of transcription, translation, and posttranslation levels of regulation of endosperm weakening in isolated CAPs. Although the impact of inhibiting translation is greater, both transcription and translation are required for the completion of endosperm weakening in the whole seed population. The majority of genes expressed during this process occur in both tissues, but where they are uniquely expressed, or significantly differentially expressed between tissues, this relates to the functions of the RAD as growing tissue and the CAP as a regulator of germination through weakening. More detailed analysis showed that putative orthologs of cell wall-remodeling genes are expressed in a complex manner during CAP weakening, suggesting distinct roles in the RAD and CAP. Expression patterns are also consistent with the CAP being a receptor for environmental signals influencing germination. Inhibitors of the aspartic, serine, and cysteine proteases reduced the number of isolated CAPs in which weakening developed, and inhibition of the 26S proteasome resulted in its complete cessation. This indicates that targeted protein degradation is a major control point for endosperm weakening.
RXR beta expression in Sertoli cells controls cholesterol homeostasis and spermiation

Somatic, targeted, inactivation of Rxrb in Sertoli cells (yielding Rxrb Ser–/– mutants) leads to failure of spermatid release, accumulation of cholesterol esters and, subsequently, testis degeneration. These abnormalities are identical, in their nature and kinetic, to those observed upon inactivating Rxrb in the whole organism, thereby demonstrating that all reproductive functions of RXR are carried out in Sertoli cells. The Rxrb Ser–/– testis degeneration is a consequence of a cholesterol ester cell overload occurring in Sertoli cells in response to reduced ABCA1-and SCARB1-mediated cholesterol efflux. The failure of spermiation was also reported in mice lacking the retinoic acid (RA) receptor alpha in Sertoli cells (Rara Ser–/– mutants) and represents, in addition, a feature of vitamin A deficiency that can be readily induced in mice lacking the lecithin:retinol acyl transferase (Lrat –/– mutants). Altogether, these findings support the conclusion that RXR heterodimerized with a RA-liganded RAR transduces signals required in Sertoli cells for spermatid release.
Neuropeptide Y, substance P, and human bone morphogenetic protein 2 stimulate human osteoblast osteogenic activity by enhancing gap junction intercellular communication

Bone homeostasis seems to be controlled by delicate and subtle “cross talk” between the nervous system and “osteo-neuromediators” that control bone remodeling. The purpose of this study was to evaluate the effect of interactions between neuropeptides and human bone morphogenetic protein 2 (hBMP2) on human osteoblasts. We also investigated the effects of neuropeptides and hBMP2 on gap junction intercellular communication (GJIC). Osteoblasts were treated with neuropeptide Y (NPY), substance P (SP), or hBMP2 at three concentrations. At various intervals after treatment, cell viability was measured by the MTT assay. In addition, cellular alkaline phosphatase (ALP) activity and osteocalcin were determined by colorimetric assay and radioimmunoassay, respectively. The effects of NPY, SP and hBMP on GJIC were determined by laser scanning confocal microscopy. The viability of cells treated with neuropeptides and hBMP2 increased significantly in a time-dependent manner, but was inversely associated with the concentration of the treatments. ALP activity and osteocalcin were both reduced in osteoblasts exposed to the combination of neuropeptides and hBMP2. The GJIC of osteoblasts was significantly increased by the neuropeptides and hBMP2. These results suggest that osteoblast activity is increased by neuropeptides and hBMP2 through increased GJIC. Identification of the GJIC-mediated signal transduction capable of modulating the cellular activities of bone cells represents a novel approach to studying the biology of skeletal innervation.
POP-VQA – Privacy preserving, On-device, Personalized Visual Question Answering

The next generation of device smartness needs to go beyond being able to understand basic user commands. As our systems become more efficient, they need to be taught to understand user interactions and intents from all possible input modalities. This is where the recent advent of large scale multi-modal models can form the foundation for next-gen technologies. However, the true power of such interactive systems can only be realized with privacy conserving personalization. In this paper, we propose an on-device visual question answering system that generates personalized answers using on-device user knowledge graph. These systems have the potential to serve as a fundamental ground-work for the development of genuinely intelligent and tailored assistants, targeted specifically to the needs and preferences of each individual. We validate our model performance on both in-realm, public datasets and personal user data. Our results show consistent performance increase across both tasks, with an absolute improvement of ≈ 36% with KVQA data-set on 1-hop inferences and ≈ 6% improvement on user personal data. We also conduct and showcase user-study results to validate our hypothesis of the need and relevance of proposed system.
Linear receivers for frequency-selective MIMO channels with redundant linear precoding can achieve full diversity

Since the introduction of the Diversity-Multiplexing Tradeoff (DMT) by Zheng and Tse for ML reception in frequency-flat MIMO channels, some results have been obtained also for the DMT of frequency-selective MIMO channels and for the DMT of suboptimal receivers such as linear (LEs) and decision-feedback equalizers (DFEs) for frequency-selective SIMO channels or frequency-flat MIMO channels. We have recently extended these results to the case of linear receivers for frequency-selective MIMO channels. However, the diversity properties of linear receivers turn out to be fairly catastrophic. In this paper we show that full diversity can be restored by the introduction of a convolutive linear MIMO precoding scheme that we showed earlier to allow to attain the optimal DMT for ML or DFE detection (in the frequency-flat case). The precoder needs to be used with a moderate amount of redundancy in the form of zero-padding, and with a MMSE design for the linear equalizer. A MMSE-ZF design also benefits substantially from the precoding. The proposed scheme is a significant extension of an earlier SISO result by Tepelenlioglu to the MIMO case.
On-chip Bus Thermal Analysis and Optimization

As technology scales, increasing clock rates, decreasing interconnect pitch, and the introduction of low-k dielectrics have made self-heating of the global interconnects an important issue in VLSI design. In this paper, we study the self-heating of on-chip buses and show that the thermal impact due to self-heating of on-chip buses increases as technology scales, thus motivating the need of finding solutions to mitigate this effect. Based on the theoretical analysis, we propose an irredundant bus encoding scheme for on-chip buses to tackle the thermal issue. Simulation results show that our encoding scheme is very efficient to reduce the on-chip bus temperature rise over substrate temperature, with much less overhead compared to other low power encoding schemes
Historical Doses from Tritiated Water and Tritiated Hydrogen Gas Released to the Atmosphere from Lawrence Livermore National Laboratory (LLNL). Part 3. Routine Releases, 1973 - 2005

Annual mean concentrations of tritium in air moisture, calculated from data obtained from an air tritium sampler near the LLNL Discovery Center, were compared with annual mean air moisture concentrations predicted from atmospheric releases of tritium for the years 1973 through 2005. The 95% confidence intervals on the predictions and observations usually overlapped. When the distributions of predictions and observations were different, predictions were higher. Using both the observed and predicted air concentrations as input to the tritium dose model, DCART, annual doses to a hypothetical adult, child (age 10) and infant (age 6 months to 1 year) assumed to be living at LLNL's Discovery Center were calculated. Although the doses based on predicted air concentrations tended to be higher, they were nevertheless indistinguishable from doses based on observed air concentrations when uncertainties were taken into account. Annual doses, calculated by DCART and based on observed and predicted air concentrations, were compared with historical tritium doses reported annually by LLNL. Although the historical doses were calculated using various assumptions over the years, their agreement with the DCART predictions is remarkable. The Discovery Center was not the location of the site-wide maximally exposed individual (SWMEI) from 1974 through 1978. However, dosesmore » at the location of the SW-MEI for those years were indistinguishable from those at the Discovery Center when uncertainties were taken into account. The upper confidence limits for all doses were always well below the current regulatory limit for dose to a member of the public (100 {micro}Sv or 10 mrem per year) from atmospheric releases (40 CFR Part 61, Subpart H). Based on observed air concentrations, the 97.5% confidence limit on the cumulative dose to the hypothetical person born in 1973 and living through 2005 at the Discovery Center was 150 {micro}Sv (15 mrem), while that of the hypothetical adult who spent his entire life at the Discovery Center was 100 {micro}Sv (10 mrem). Comparable doses calculated from predicted air concentrations were about 35% greater. The comparison of predicted and observed air concentrations demonstrate that some reasonable confidence can be placed in the concentrations that will be predicted from tritium releases to the atmosphere in Part IV (1953 - 1972) of the Tritium Dose Reconstruction; because dose estimations are linearly related to air concentrations, reasonable confidence can also be placed in the doses that will be predicted. « less
HUMAN PAPILOMA VIRUSES DETECTION IN ADOLESCENT WOMEN WITH ABNORMALN CYTOLOGY IN CROATIA

The association between certain human papillomaviruses (HPV) and cervical intraepithelial neoplasia (CIN) is well documented, but still unknown among Croatian adolescent women. Women between the age of 15 and 20 with cytomorphologically abnormal smears (CIN I-IV) were tested for the presence of HPV. Consensus and specific primers were used in the polymerase chain reaction (PCR to detect the most common types: 6, 11, 16, 18, 31 and 33. Beside low-risk HPV 6/11 (25.8%) the most frequently observed types were high-risk HPV types 16 (20.2%) and 31 (17.8%). Globally, the HPV positivity rate declines with age. The presence of HPV DNA significantly increased from 35.5 to 61.1% along with the severity of the cervical intraepithelial neoplasia (CIN I-IV). HPV type 6/11 was strong associated with CIN I (33.8%), HPV type 31 with CIN II (22.9%) and HPV type 16 with CIN III (50%).
Evaluation of bone loss in diabetic postmenopausal women

Background: Osteoporosis and diabetes mellitus are major and growing public health problems particularly among postmenopausal women. This study was conducted to evaluate the relationship between osteoporosis and osteopenia with type 2 diabetes mellitus (DM) in postmenopausal women. Materials and Methods: In a cross sectional study, we compared 200 diabetic postmenopausal women with 400 non-diabetic postmenopausal women over the age of 60 years. Age, Body Mass Index (BMI), T score of the lumbar vertebra (L2-L4) and femoral neck were measured with Dual Energy X-ray Absorptiometry (DXA) and were compared between the two groups. Hemoglobin A1C (HbA1C) was also measured in patients with type 2 DM and its relationship with osteoporosis was studied. Chi-square, Fisher's exact test and Independent T-test was used for analyzing the data. The statistical significance was set at a P value of 0.05 or lower. Results: Mean, SD ages were 65.23 ± 4.80 vs. 66.91 ± 5.78 years and BMI were 28.94 ± 4.06 vs. 31.65 ± 4.42 kg/m2 in non-diabetic and diabetic groups, respectively. Lumber T scores was -2.10 ± 1.08 vs.-2.16 ± 1.27 (P = 0.60), femoral neck T-score was -0.72 ± 1.00 vs. -1.09 ± 0.96 (P = 0.00) in non-diabetic and diabetic groups, respectively. There was a significant difference in femoral neck T score between the diabetic and non-diabetic group (P = 0.00). In diabetic women, bone loss was more common in those with HbA1C ≥7 compare to those with HbA1C <7 (P = 0.006). Conclusion: Osteopenia and osteoporosis is more common in diabetic postmenopausal women compare to the non-diabetic postmenopausal women.
Insights on prediction of patients' response to anti-HIV therapies through machine learning

We collect data from the HIV Resistance Drug Database and, based on CD4+ and viral load measures, together with RNA sequences of the reverse transcriptase and of the protease of the virus, we design models using machine learning techniques MultiLayer Perception (MLP), Radial Basis Function (RBF), and Support Vector Machine (SVM), to predict the patient's response to anti-HIV treatment. In this work we applied the SMOTE Algorithm to deal with the enormous difference between the number of case and control samples, which was crucial for the accuracy of the models. Our results show that the SVM model proved more accurate than the other two, with a ROC curve area of 0.9398. We observe that, from 1000 patients, there are 646 samples for which the three methods delivered correct predictions. On the other hand, for 69 patients all three models fail. We analyzed the data for those patients more carefully, and we identified codons and properties that are important for a response/non-response result. Among the codons that our models identified, there are several with strong support from the literature and also a few new ones. Our analysis offers numerous insights that can be very useful to the prediction of patients' response to anti-HIV therapies in the future.
Management of XML data by means of schema matching

XML Schema Definition is a recommendation from World Wide Web Consortium that specifies the elements All, News, Get Started, Evaluate, Manage, Problem Solve Consider niche tech XQuery to bring improvements to data integration. Georg Gottlob MASTER THESIS Schema Matching and Automatic Web Data can mean any model, for instance, an XML schema, interface definition, semantic management it became a separate research topic under the title of schema. Information Management, 7, 22-32. dx.doi. org/10.4236/iim.2015. 71003 DDLs are identical in their core, thus explaining why even XML and Ontologies have Software Engineering, Data Definition, Schema Matching, Data Integration.
Quality and Safety of Platelet Apheresis Concentrates Produced with a New Leukocyte Reduction System

Objectives: Contaminating white blood cells (WBC) in apheresis platelet concentrates (PC) can cause a variety of adverse effects after platelet transfusion. To obtain PCs with low WBC contamination, a new leukoreduction system (LRS) utilizing ‘fluidized particle bed’ technology has recently been introduced. Methods: We prospectively examined the effect of LRS apheresis on the donor, the quality of the resulting PCs (n = 120), and the platelet increment in the corresponding recipients. Conventionally prepared apheresis PCs served as control group (n = 27). Platelet glycoproteins were examined by flow cytometry. Results: In LRS apheresis, we observed no serious adverse effects on the donors, but the postdonation absolute lymphocyte counts were reduced from 1,787±505/μl to 1,405±383/μl (p < 0.001). Comparable results were seen in non-LRS donors. The collection efficiency of the LRS procedures was 50.0±7.6%, resulting in a yield of 4.3±1.0 × 1011 platelets/PC. In flow cytometry, platelet glycoproteins in LRS PCs were not elevated: mean fluorescence of CD62 (6±4) or CD63 (9±3) in comparison with non-LRS PCs (mean fluorescence of CD62: 7±4, CD63: 8±3). Median leukocyte contamination of the LRS PCs was 0.41 × 105 (range 0.07–8.5) WBCs/unit. In 43 recipients, the 24-hour corrected count increments after transfusion of LRS PCs (12,530±8,761) were essentially the same as those of 20 recipients of non-LRS PCs (13,133±9,812; p = 0.75). Conclusions: LRS apheresis appears to be a safe procedure, which produced effective PCs with few contaminating leukocytes. With new apheresis technology, filtration of PCs may become superfluous.
LEOPARD syndrome-associated SHP2 mutation confers leanness and protection from diet-induced obesity

Significance LEOPARD syndrome (multiple Lentigines, Electrocardiographic conduction abnormalities, Ocular hypertelorism, Pulmonary stenosis, Abnormal genitalia, Retardation of growth, sensorineural Deafness; LS) is a rare genetic disease associating various developmental defects mainly caused by inactivating mutations of the tyrosine phosphatase SHP2 (Src-homology 2 domain-containing phosphatase 2). SHP2 is a key regulator of essential signaling pathways (MAPK, PI3K), which confer on SHP2 major roles in development and metabolism control. However, nothing is known about the metabolic status of LS. We thus performed an extensive metabolic exploration of an original LS mouse model. These mice display a lean phenotype (reduced adiposity, improved carbohydrate metabolism), translating into resistance to obesity and associated disorders upon obesogenic diet. This phenotype correlated with defective adipogenesis, better insulin signaling, and enhanced energy expenditure and was partially corrected by MAPK inhibition. Preliminary data in LS patients are in agreement with these findings. LEOPARD syndrome (multiple Lentigines, Electrocardiographic conduction abnormalities, Ocular hypertelorism, Pulmonary stenosis, Abnormal genitalia, Retardation of growth, sensorineural Deafness; LS), also called Noonan syndrome with multiple lentigines (NSML), is a rare autosomal dominant disorder associating various developmental defects, notably cardiopathies, dysmorphism, and short stature. It is mainly caused by mutations of the PTPN11 gene that catalytically inactivate the tyrosine phosphatase SHP2 (Src-homology 2 domain-containing phosphatase 2). Besides its pleiotropic roles during development, SHP2 plays key functions in energetic metabolism regulation. However, the metabolic outcomes of LS mutations have never been examined. Therefore, we performed an extensive metabolic exploration of an original LS mouse model, expressing the T468M mutation of SHP2, frequently borne by LS patients. Our results reveal that, besides expected symptoms, LS animals display a strong reduction of adiposity and resistance to diet-induced obesity, associated with overall better metabolic profile. We provide evidence that LS mutant expression impairs adipogenesis, triggers energy expenditure, and enhances insulin signaling, three features that can contribute to the lean phenotype of LS mice. Interestingly, chronic treatment of LS mice with low doses of MEK inhibitor, but not rapamycin, resulted in weight and adiposity gains. Importantly, preliminary data in a French cohort of LS patients suggests that most of them have lower-than-average body mass index, associated, for tested patients, with reduced adiposity. Altogether, these findings unravel previously unidentified characteristics for LS, which could represent a metabolic benefit for patients, but may also participate to the development or worsening of some traits of the disease. Beyond LS, they also highlight a protective role of SHP2 global LS-mimicking modulation toward the development of obesity and associated disorders.
Effect of Dose and Time of Paclobutrazol Application on the Flowering, Fruit Yield and Quality of Mango Cv. Alphonso

A field trial was conducted for eight years at Indian Institute of Horticulture Research, Bengaluru to find out the effect of dose and time of application of paclobutrazol (PBZ) on flowering, fruit yield and quality of 'Alphonso' mango. The percentages of flowering, vegetative and dormant shoots were affected by paclobutrazol application. Different dose and time of application of paclobutrazol increased the percentage of flowering shoots significantly and most pronounced effect was with treatment D1T2 (3ml/m canopy PBZ applied 90 days before bud break) which recorded 89.9% flowering shoots as compared to 73.8% in control treatment. Regarding fruit yield, maximum mean fruit yield of 22.0kg/plant was recorded with treatment D1T2 (3ml/m canopy PBZ applied 90 days before bud break) and least was with control (13.1kg/plant) which accounts for fruit yield increase of 67.9%. No particular trend was observed in respect of shoot length in different treatments. However in general, paclobutrazol application reduced the shoot length compared to control. With respect of fruit quality attributes, acidity and TSS were found to be non-significant among different treatments during different years. Average fruit weight was found to be significant during different years and paclobutrazol application reduced the average fruit size compared to control. Cost benefit ratio was maximum of 1:2.52 was with treatment 3ml/m canopy PBZ applied 90 days before bud break and least cost benefit ratio of 1:1.06 was with control.