Miracle-dz/UniFAR-FTUs huggingface dataset:
An Extensive Comparison of the Effect of Anthelmintic Classes on Diverse Nematodes

Soil-transmitted helminths are parasitic nematodes that inhabit the human intestine. These parasites, which include two hookworm species, Ancylostoma duodenale and Necator americanus, the whipworm Trichuris trichiura , and the large roundworm Ascaris lumbricoides , infect upwards of two billion people and are a major cause of disease burden in children and pregnant women. The challenge with treating these diseases is that poverty, safety, and inefficient public health policy have marginalized drug development and distribution to control infection in humans. Anthelmintics (anti-worm drugs) have historically been developed and tested for treatment of non-human parasitic nematodes that infect livestock and companion animals. Here we systematically compare the in vitro efficacy of all major anthelmintic classes currently used in human therapy (benzimidazoles, nicotinic acetylcholine receptor agonists, macrocyclic lactones, nitazoxanide) against species closely related to human parasitic nematodes-Ancylostoma ceylanicum, Trichuris muris , and Ascaris suum --- as well as a rodent parasitic nematode used in veterinary drug discovery, Heligmosomoides bakeri , and the free-living nematode Caenorhabditis elegans. Extensive in vitro data is complemented with single-dose in vivo data in three rodent models of parasitic diseases. We find that the effects of the drugs in vitro and in vivo can vary greatly among these nematode species, e.g., the efficacy of albendazole is strong on A. ceylanicum but weak on H . bakeri . Nonetheless, certain commonalities of the in vitro effects of the drugs can be seen, e.g., nitazoxanide consistently shows an all-or-nothing response. Our in vitro data suggest that further optimization of the clinical efficacy of some of these anthelmintics could be achieved by altering the treatment routine and/or dosing. Most importantly, our in vitro and in vivo data indicate that the hookworm A. ceylanicum is a particularly sensitive and useful model for anthelmintic studies and should be incorporated early on in drug screens for broad-spectrum human soil-transmitted helminth therapies.
Reducing contingent self-worth: A defensive response to self-threats

ABSTRACT Previous research shows that people with high self-esteem cope with threats to the self by reducing the extent to which their self-worth is contingent on the threatened domain (Buckingham, Weber, & Sypher, 2012). The present studies tested the hypothesis that this is a defensive process. In support of this hypothesis, Study 1 (N = 160), showed that self-affirmation attenuates the tendency for people with high self-esteem to reduce their contingencies of self-worth following self-threat. Furthermore, Study 2 (N = 286), showed that this tendency was more prevalent among people with defensive self-esteem than among those with secure self-esteem. The present studies imply that reducing contingent self-worth after self-threat is a defensive process. We discuss implications for theories of contingent self-worth.
Sustained IFN-I Expression during Established Persistent Viral Infection: A “Bad Seed” for Protective Immunity

Type I interferons (IFN-I) are one of the primary immune defenses against viruses. Similar to all other molecular mechanisms that are central to eliciting protective immune responses, IFN-I expression is subject to homeostatic controls that regulate cytokine levels upon clearing the infection. However, in the case of established persistent viral infection, sustained elevation of IFN-I expression bears deleterious effects to the host and is today considered as the major driver of inflammation and immunosuppression. In fact, numerous emerging studies place sustained IFN-I expression as a common nexus in the pathogenesis of multiple chronic diseases including persistent infections with the human immunodeficiency virus type 1 (HIV-1), simian immunodeficiency virus (SIV), as well as the rodent-borne lymphocytic choriomeningitis virus clone 13 (LCMV clone 13). In this review, we highlight recent studies illustrating the molecular dysregulation and resultant cellular dysfunction in both innate and adaptive immune responses driven by sustained IFN-I expression. Here, we place particular emphasis on the efficacy of IFN-I receptor (IFNR) blockade towards improving immune responses against viral infections given the emerging therapeutic approach of blocking IFNR using neutralizing antibodies (Abs) in chronically infected patients.
Social network members who engage in activities with older adults: do they bring more social benefits than other members?

ABSTRACT Active participation in social activities is important for the wellbeing of older adults. This study explored benefits of active social engagement by evaluating whether relationships that comprise active involvement (e.g. co-engagement in activities) bring more social benefits (i.e. social support, companionship, positive social influence) than other relationships that do not involve co-engagement. A total of 133 adults ages 60 years and older living in a rural Midwestern city in the United States of America were interviewed once and provided information on 1,740 social network members. Among 1,506 social relationships in which interactions occurred at least once a month, 52 per cent involved engagement in social activities together and 35 per cent involved eating together regularly. Results of the generalised linear mixed model showed that relationships involving co-engagement were significantly more likely to also convey social support (i.e. emotional, instrumental, informational), companionship and social influence (encouragement for healthy behaviours) than relationships that do not involve co-engagement. Having more network members who provide companionship was associated with higher sense of environmental mastery, positive relations with others and satisfaction with social network. Interventions may focus on maintaining and developing such social relationships and ensuring the presence of social settings in which co-engagement can occur. Future research may explore whether increasing co-engagement leads to an enhanced sense of companionship and psychological wellbeing.
17β‐Estradiol administration promotes delayed cutaneous wound healing in 40‐week ovariectomised female mice

This study investigated the effect of 17β‐estradiol on wound healing in 40‐week ovariectomised female mice. Thirty‐six‐week‐old female mice were divided into three groups: medication with 17β‐estradiol after ovariectomy (OVX + 17β‐estradiol), ovariectomy (OVX) and sham (SHAM). The mice received two full‐thickness wounds, and the OVX + 17β‐estradiol group was administered 17β‐estradiol at 0·01 g/day until healing. In the OVX + 17β‐estradiol group, the ratio of wound area was significantly smaller than those of the OVX and SHAM groups on days 1–3, 5, 6, 8–12 and 9–12, respectively, the numbers of neutrophils and macrophages were significantly smaller than those on days 3 and 7, the ratio of re‐epithelialisation was significantly higher than those on days 3 and 11, the ratio of myofibroblasts was significantly higher than those on day 11 and smaller on day 14, and the ratio of collagen fibres was significantly larger than that of the OVX group on days 7–14. We found that 17β‐estradiol administration promotes cutaneous wound healing in 40‐week female mice by reducing wound area, shortening inflammatory response, and promoting re‐epithelialisation, collagen deposition and wound contraction. Our results suggest that cutaneous wound healing that is delayed because of ageing is promoted by exogenous and continuous 17β‐estradiol administration.
Electric Field‐Induced Light Scattering in Eu‐Doped PMN‐PT Transparent Ceramics

Highly transparent Eu-doped Pb(Mg1/3Nb2/3)O3–PbTiO3(PMN-PT) ferroelectric ceramics were obtained by a two-stage sintering method. Eu doping play a significant role in the domain structures of PMN-PT ceramics and resulted in different light scattering responses under electric field. The dielectric behaviors, ferroelectric properties, and domain configurations in the ceramics with increasing Eu doping concentration were studied, which were consistent with the electric field-induced light scattering responses.
Parametrizing Flat-Foldable Surfaces with Incomplete Data

We propose a novel way of computing surface folding maps via solving a linear PDE. This framework is a generalization to the existing quasiconformal methods and allows manipulation of the geometry of folding. Moreover, the crucial quantity that characterizes the geometry occurs as the coefficient of the equation, namely the Beltrami coefficient. This allows us to solve an inverse problem of parametrizing the folded surface given only partial data but with known folding topology. Various interesting applications such as fold sculpting on 3D models and self-occlusion reasoning are demonstrated to show the effectiveness of our method.
Bergmann’s Clines in Ectotherms: Illustrating a Life‐History Perspective with Sceloporine Lizards

The generality and causes of Bergmann’s rule have been debated vigorously in the last few years, but Bergmann’s clines are rarely explained in the context of life‐history theory. We used both traditional and phylogenetic comparative analyses to explore the causes of latitudinal and thermal clines in the body size of the eastern fence lizard (Sceloporus undulatus). The proximate mechanism for larger body sizes in colder environments is delayed maturation, which results in a greater fecundity but a lower survival to maturity. Life‐history theory predicts that a higher survivorship of juveniles in colder environments can favor the evolution of a Bergmann’s cline. Consistent with this theory, lizards in colder environments survive better as juveniles and delay maturation until reaching a larger body size than that of lizards in warmer environments. We expect similar relationships among temperature, survivorship, and age/size at maturity exist in other ectotherms that exhibit Bergmann’s clines. However, life‐history traits of S. undulatus were more strongly related to latitude than they were to temperature, indicating that both abiotic and biotic factors should be considered as causes of Bergmann’s clines. Nonetheless, analyses of the costs and benefits of particular body sizes in different thermal environments will enhance our understanding of geographic variation.
Cognitive Behavior Classification From Scalp EEG Signals

Electroencephalography (EEG) has become increasingly valuable outside of its traditional use in neurology. EEG is now used for neuropsychiatric diagnosis, neurological evaluation of traumatic brain injury, neurotherapy, gaming, neurofeedback, mindfulness, and cognitive enhancement training. The trend to increase the number of EEG electrodes, the development of novel analytical methods, and the availability of large data sets has created a data analysis challenge to find the “signal of interest” that conveys the most information about ongoing cognitive effort. Accordingly, we compare three common types of neural synchrony measures that are applied to EEG—power analysis, phase locking, and phase-amplitude coupling to assess which analytical measure provides the best separation between EEG signals that were recorded, while healthy subjects performed eight cognitive tasks—Hopkins Verbal Learning Test and its delayed version, Stroop Test, Symbol Digit Modality Test, Controlled Oral Word Association Test, Trail Marking Test, Digit Span Test, and Benton Visual Retention Test. We find that of the three analytical methods, phase-amplitude coupling, specifically theta (4–7 Hz)—high gamma (70–90 Hz) obtained from frontal and parietal EEG electrodes provides both the largest separation between the EEG during cognitive tasks and also the highest classification accuracy between pairs of tasks. We also find that phase-locking analysis provides the most distinct clustering of tasks based on their utilization of long-term memory. Finally, we show that phase-amplitude coupling is the least sensitive to contamination by intense jaw-clenching muscle artifact.
Hepatitis B Virus Infection of a Mouse Hepatic Cell Line Reconstituted with Human Sodium Taurocholate Cotransporting Polypeptide

ABSTRACT Hepatitis B virus (HBV) enters hepatocytes via its receptor, human sodium taurocholate cotransporting polypeptide (hNTCP). So far, HBV infection has been achieved only in human hepatic cells reconstituted with hNTCP and not in cells of mouse origin. Here, the first mouse liver cell line (AML12) which gains susceptibility to HBV upon hNTCP expression is described. Thus, HBV infection of receptor-expressing mouse hepatocytes does not principally require a human cofactor but can be triggered by endogenous murine determinants.
Deep Learning-Aided SCMA

Sparse code multiple access (SCMA) is a promising code-based non-orthogonal multiple-access technique that can provide improved spectral efficiency and massive connectivity meeting the requirements of 5G wireless communication systems. We propose a deep learning-aided SCMA (D-SCMA) in which the codebook that minimizes the bit error rate (BER) is adaptively constructed, and a decoding strategy is learned using a deep neural network-based encoder and decoder. One benefit of D-SCMA is that the construction of an efficient codebook can be achieved in an automated manner, which is generally difficult due to the non-orthogonality and multi-dimensional traits of SCMA. We use simulations to show that our proposed scheme provides a lower BER with a smaller computation time than conventional schemes.
Using a Simple Neural Network to Delineate Some Principles of Distributed Economic Choice

The brain uses a mixture of distributed and modular organization to perform computations and generate appropriate actions. While the principles under which the brain might perform computations using modular systems have been more amenable to modeling, the principles by which the brain might make choices using distributed principles have not been explored. Our goal in this perspective is to delineate some of those distributed principles using a neural network method and use its results as a lens through which to reconsider some previously published neurophysiological data. To allow for direct comparison with our own data, we trained the neural network to perform binary risky choices. We find that value correlates are ubiquitous and are always accompanied by non-value information, including spatial information (i.e., no pure value signals). Evaluation, comparison, and selection were not distinct processes; indeed, value signals even in the earliest stages contributed directly, albeit weakly, to action selection. There was no place, other than at the level of action selection, at which dimensions were fully integrated. No units were specialized for specific offers; rather, all units encoded the values of both offers in an anti-correlated format, thus contributing to comparison. Individual network layers corresponded to stages in a continuous rotation from input to output space rather than to functionally distinct modules. While our network is likely to not be a direct reflection of brain processes, we propose that these principles should serve as hypotheses to be tested and evaluated for future studies.
Practical guidance for using multiple data sources in systematic reviews and meta‐analyses (with examples from the MUDS study)

Data for individual trials included in systematic reviews may be available in multiple sources. For example, a single trial might be reported in 2 journal articles and 3 conference abstracts. Because of differences across sources, source selection can influence the results of systematic reviews. We used our experience in the Multiple Data Sources in Systematic Reviews (MUDS) study, and evidence from previous studies, to develop practical guidance for using multiple data sources in systematic reviews.
Oestrogen and progesterone receptors in melanoma and nevi: an immunohistochemical study

BackgroundThe effect of hormonal stimulation and fertility treatments, on the development of malignant melanoma (MM) remains to be determined.ObjectivesThe aim of this study was to investigate the presence of oestrogen receptor alpha (ERα) and progesterone receptor (PR) inMM and nevi after hormonal stimulation.Materials & MethodsImmunohistochemical analyses were performed utilizing antibodies specifically directed against ERα and PR in MM and atypical nevi specimens from patients: (1) diagnosed during pregnancy, (2) diagnosed in the six months following delivery, or (3) who had undergone repetitive cycles of hormonal stimulation for in vitro fertilization (IVF) in the year that preceded MM diagnosis. Controls were atypical nevi and MM specimens of female patients of the same age group who had received no hormonal therapies and reported no pregnancies in the five years before diagnosis.ResultsTwenty-eight female patients at childbearing age were selected for this study. Strong cytoplasmic positivity of ERα and PRwas detected in atypical melanocytes of two MM specimens of patients who had undergone repetitive cycles of hormonal stimulation during IVF procedures. All other specimens showed no expression ofERαor PR.ConclusionSince our results represent preliminary findings, conclusions regarding a possible correlation between IVF therapy and melanoma occurrence cannot be ascertained. Larger laboratory studies should be performed to investigate reproductive hormone receptor expression in MM in women following IVF, pregnancy, prolonged contraceptive use, or hormone replacement therapy.
Hypoxia inducible factors in hepatocellular carcinoma

Hepatocellular carcinoma is one of the most prevalent and lethal cancers with limited therapeutic options. Pathogenesis of this disease involves tumor hypoxia and the activation of hypoxia inducible factors. In this review, we describe the current understanding of hypoxia signaling pathway and summarize the expression, function and target genes of hypoxia inducible factors in hepatocellular carcinoma. We also highlight the recent progress in hypoxia-targeted therapeutic strategies in hepatocellular carcinoma and discuss further the future efforts for the study of hypoxia and/or hypoxia inducible factors in this deadly disease.
Polymorphisms in the microglial marker molecule CX3CR1 affect the blood volume of the human brain

CX3CR1, a G‐protein‐coupled receptor, is involved in various inflammatory processes. Two non‐synonymous single nucleotide polymorphisms, V249I (rs3732379) and T280M (rs3732378), are located in the sixth and seventh transmembrane domains of the CX3CR1 protein, respectively. Previous studies have indicated significant associations between T280M and leukocyte functional characteristics, including adhesion, signaling, and chemotaxis, while the function of V249I is unclear. In the brain, microglia are the only proven and widely accepted CX3CR1‐expressing cells. This study aimed to specify whether there were specific brain regions on which these two single nucleotide polymorphisms exert their biological impacts through their functional effects on microglia.
The Journal of General Physiology

The whole activity cycle of muscle can be reproduced in glycerol-extracted muscle fibers by suspending them in solutions containing adenosinetriphos-phate (ATP) and certain ions, particularly Mg and Ca ions (1). Quantitatively, however, the agreement between the responses of normal and extracted muscle fibers is disappointing. Relaxation induced by ATP in extracted muscle fibers is too slow and is associated with a high rate of P liberation. Also, in the contracted state enzymatic activity is much lower in extracted than in normal muscle (2). In the search for a better reconstruction of muscular activity the action of phosphocreatine (PC) was investigated. Indeed, this substance was found to intensify the actions of ATP to a surprising degree, to increase the tension of contracted fibers, and to accelerate relaxation. The interpretation of these phenomena which will be presented here is based on the accepted view that PC does not directly furnish energy for contraction, but is important for the rapid phosphorylation of adenosinemonophosphate (AMP) and adenosine-diphosphate (ADP). Beyond that, the study of the effects of PC has led to the conclusion that contraction requires only a small amount of adenine nucleotide firmly bound to the contractile elements. Technique The rabbit's psoas muscle preserved in 50 per cent glycerol at about-1 5 ° was used. The preparations, which had a total cross-sectional area of about 0.2 ram3, were suspended in a small chamber as described previously (1). They were divided into at least 12 strands to facilitate diffusion (2). The mechanical responses were recorded on a smoked drum by an isometric lever. Before an experiment the fibers were transferred into a solution which contained 0.16 M KC1 and 2 m • MgCI~ and which will be referred to as saline. All other solutions used contained nearly the same concentrations of KC1 and MgC12. Solutions of PC were prepared from commercial Na salt (Sigma Chemical Co., St. Louis), those of ATP were prepared from the Na or Ba salt (Nutrition Biochemical Corporation, Cleveland, and Sigma Chemical Company, respectively). These solutions were usually buffered by 0.02 M glycylglycine of pH 6.9, but exactly the same results were obtained without buffer. PC was always used at a concentration of 20 m~t per liter, approximately that in normal muscle. Most experiments were carried out at room temperature (21-24°).
Force over ̄ ow and levodopa-induced dyskinesias in Parkinson ' s disease

We assessed force coordination of the hand in Parkinson's disease and its relationship to motor complications of levodopa therapy, particularly to levodopainduced dyskinesias (LID). We studied two groups of Parkinson's disease patients with (Parkinson's disease + LID, n = 23) and without levodopa-induced dyskinesias (Parkinson's disease ± LID, n = 10), and age-matched healthy controls. The motor score of the Uni®ed Parkinson's Disease Rating Scale, a dyskinesia score and force in a grip±lift paradigm were assessed ON and OFF levodopa. A pathological increase of forces was seen in ON-state in Parkinson's disease + LID only. In Parkinson's disease + LID, the force involved in pressing down the object before lifting was signi®cantly increased by levodopa (by 61%, P < 0.05). An overshooting of peak grip force by 51% (P < 0.05) and of static grip force by 45% (P < 0.01) was observed in the ONcompared with the OFF-drug condition. In contrast, no excessive force was found in Parkinson's disease ± LID. Peak grip force in ON-state was 140% (P < 0.05) higher in Parkinson's disease + LID than in Parkinson's disease ± LID, while static grip force was increased by 138% (P < 0.01) between groups. Severity of peak-dose dyskinesias was strongly correlated with grip force in ON-state (r = 0.79 with peak force, P < 0.01). No correlation was observed between forces and the motor score as well as with the daily dose of dopaminergic medication. Force excess was only observed in patients with LID and motor ̄uctuations. A close relationship was seen between the overshooting of forces and dyskinesias in the ON-drug condition. We postulate that both LID and grip force excess share common pathophysiological mechanisms related to motor ̄uctuations.