Miracle-dz/UniFAR-FTUs huggingface dataset:
The Neuronal Basis of Attention: Rate versus Synchronization Modulation

Extensive theoretical and experimental work on the neuronal correlates of visual attention raises two hypotheses about the underlying mechanisms. The first hypothesis, named biased competition, originates from experimental single-cell recordings that have shown that attention upmodulates the firing rates of the neurons encoding the attended features and downregulates the firing rates of the neurons encoding the unattended features. Furthermore, attentional modulation of firing rates increases along the visual pathway. The other, newer hypothesis assigns synchronization a crucial role in the attentional process. It stems from experiments that have shown that attention modulates gamma-frequency synchronization. In this paper, we study the coexistence of the two phenomena using a theoretical framework. We find that the two effects can vary independently of each other and across layers. Therefore, the two phenomena are not concomitant. However, we show that there is an advantage in the processing of information if rate modulation is accompanied by gamma modulation, namely that reaction times are shorter, implying behavioral relevance for gamma synchronization.
Pemetrexed versus pemetrexed and carboplatin as second-line chemotherapy in advanced non-small-cell lung cancer: results of the GOIRC 02-2006 randomized phase II study and pooled analysis with the NVALT7 trial.

PURPOSE To compare efficacy of pemetrexed versus pemetrexed plus carboplatin in pretreated patients with advanced non-small-cell lung cancer (NSCLC). PATIENTS AND METHODS Patients with advanced NSCLC, in progression during or after first-line platinum-based chemotherapy, were randomly assigned to receive pemetrexed (arm A) or pemetrexed plus carboplatin (arm B). Primary end point was progression-free survival (PFS). A preplanned pooled analysis of the results of this study with those of the NVALT7 study was carried out to assess the impact of carboplatin added to pemetrexed in terms of overall survival (OS). RESULTS From July 2007 to October 2009, 239 patients (arm A, n = 120; arm B, n = 119) were enrolled. Median PFS was 3.6 months for arm A versus 3.5 months for arm B (hazard ratio [HR], 1.05; 95% CI, 0.81 to 1.36; P = .706). No statistically significant differences in response rate, OS, or toxicity were observed. A total of 479 patients were included in the pooled analysis. OS was not improved by the addition of carboplatin to pemetrexed (HR, 90; 95% CI, 0.74 to 1.10; P = .316; P heterogeneity = .495). In the subgroup analyses, the addition of carboplatin to pemetrexed in patients with squamous tumors led to a statistically significant improvement in OS from 5.4 to 9 months (adjusted HR, 0.58; 95% CI, 0.37 to 0.91; P interaction test = .039). CONCLUSION Second-line treatment of advanced NSCLC with pemetrexed plus carboplatin does not improve survival outcomes as compared with single-agent pemetrexed. The benefit observed with carboplatin addition in squamous tumors may warrant further investigation.
False cerebral activation on BOLD functional MR images: study of low-amplitude motion weakly correlated to stimulus.

BACKGROUND AND PURPOSE Movements of the participant during blood oxygen level-dependent (BOLD) functional MR imaging cerebral activation studies are known to produce occasionally regions of false activation, especially when these movements are relatively large (>3 mm) and highly correlated with the stimulus. We investigated whether minimal (<1 mm), weakly correlated movements in a controlled functional MR imaging model could produce false activation artifacts that could potentially mimic regions of true activation in size, location, and statistical significance. METHODS A life-size brain phantom was constructed by embedding vials of a dilute carboxylic acid solution within a gadolinium-doped gelatin mold. Imaging was performed at 1.5 T using a 2D spiral sequence (3,000/5 [TR/TE]; flip angle, 88 degrees; matrix, 64 x 64; field of view, 24 cm; section thickness, 5 mm). Controlled, in-plane, submillimeter movements of the phantom were generated using a pneumatic system and were made to correlate with a hypothetical "boxcar" stimulus over the range 0.31 < r < 0.96. Regions of false activation were sought using standard statistical methods (SPM96) that excluded phantom edges and accounted for spatial extent (regions tested at P < .05, corrected for multiple comparisons). A similar experiment was performed on a resting volunteer. RESULTS The pneumatic system provided motion control with average in-plane displacements and rotations of 0.74 mm and 0.47 degrees, respectively, in the 18 data sets analyzed. No areas of false activation in the phantom were identified for poorly correlated motions (r < 0.52). Above this level, false activations occurred with increasing frequency, scaling in size and number with the degree of motion correlation. For motions with r > 0.67, areas of false activation were seen in every experiment. For a statistical threshold of P = . 001, the median number of falsely activated regions was 3.5, with a mean size of 71.7 voxels (approximately 5 cc). Areas of possibly false activation of average size 72.5 voxels resulting from passive motion of the resting human participant were observed in two of four experiments. CONCLUSION Participant movements of 1 mm or less that are only modestly correlated with a blocked stimulus paradigm can produce appreciable false activation artifacts on BOLD functional MR imaging studies, even when strict image realignment methods are used to prevent them.
Preliminary and incomplete THE REAL EFFECTS OF LOCAL FINANCIAL DEVELOPMENT

We construct a new indicator of financial development by estimating a regional effect on the probability that, ceteris paribus, a household is shut off from the credit market. By using this indicator we explore the real effects of regional differences in financial development. We find that financial development enhances the probability an individual starts his own business, favors entry, increases competition, and promotes growth of firms. As predicted by theory, these effects are weaker for larger firms, which can more easily raise funds outside of the local area. Overall, the results suggest local financial development is an important determinant of the economic success of an area.
Multifrequency Study of Giant Radio Pulses from the Crab Pulsar with the K5 VLBI Recording Terminal

AbstractSimultaneous multifrequency observations of the Crab pulsar giant pulses (GPs)were performed with the 64-m Kalyazin radio telescope at four frequencies ν = 0.6,1.4, 2.2 and 8.3 GHz, using the K5 VLBI recording terminal. The K5 terminal pro-vided continuous recording in 16 4-MHz wide frequency channels distributed over 4frequency bands. Several thousand GPs were detected during about 6 hours of obser-vations in two successive days in July 2005. Radio spectra of single GPs were analysedat separate frequencies and over the whole frequency range. These spectra mani-fest notable modulation over frequency ranges, ∆ν, both on large (∆ν/ν ≈ 0.5) andsmall (∆ν/ν ≈ 0.01) frequency scales. Cross-correlation analysis of GPs at 2.2 GHzshowed that their pulse shapes can be interpreted as an ensemble of unresolved burstsgrouped together at time scales of ≈1 µs being well-correlated over a 60-MHz band.The corresponding GP cross-correlation functions do not obey the predictions of theamplitude-modulated noise model of Rickett (1975), thus indicating that unresolvedcomponents represent a small number of elementary emitters.Key words: Pulsars — giant pulses, Crab pulsar, PSR B0531+21 — e-VLBI1
Age and gender differences in endogenous eyeblinks and the standard blink rate of normal adults.

The major purpose of this study was to establish the standard rate of blinking in adults using relatively large samples of subjects. A subsidiary purpose was to investigate gender and age differences in eyeblink behaviors. The identical task, watching an edited video tape for three minutes, was administered to 671 subjects aged from 20 to 93 years. Eyeblinks of each person were videotaped during task performance and were analyzed using a special software. The results were as follows: (a) the average blink rate in adulthood was approximately 20 blinks per minute, (b) no remarkable age effects was found, but (c) the gender difference in eyeblink rate was significant, with females blinking more frequently than males. In addition, the opening and closing durations of eyeblinks, the synchronization between right and left eyelids, and the effects of wearing contact lenses and eyeglasses on eyeblink rates were examined in terms of age and gender differences. A specific influence of contact lens wearing on blink rate was obtained, namely a significant increase in blinking and prolongation of blink duration. (Japanese Journal of Physiological Psychology and Psychophysiology, 25(3) : 255-265, 2007. )
Restitution of Swallowing in the Fetal Sheep Restores Intestinal Growth after Midgestation Esophageal Obstruction

We have shown that, in the fetal sheep, abolition of fluid ingestion early in gestation results in a profound gastrointestinal tract (GIT)-specific growth retardation and that these effects can be reversed if fetal swallowing is restored, even for relatively short periods (15 days). The fetal esophagus was ligated at 60-65 days of gestation in 11 fetal sheep (term is 145-148 days). At 136 days of gestation, body and tissue growth of six fetuses were compared to eight age-matched control fetuses. There were no effects on body growth, but the growth of the GIT was significantly retarded. The small intestine was the most severely affected region; villi were smaller in both proximal and distal regions, and villus density was increased and crypt density decreased. The growth-retarding effects are progressive such that they become more pronounced as the period of absence of swallowed input to the GIT is increased. Thus the effects observed in our study (ingestion abolished for approximately 80 days) are much more marked than those in our earlier short-term studies (40-50 days). Five of the fetuses with esophageal ligations underwent further surgery at approximately 120 days' gestation to correct the esophageal obstruction so as to allow the resumption of fluid ingestion. By 136 days, the values of most intestinal morphological parameters had begun to move toward control values. (ABSTRACT TRUNCATED AT 250 WORDS)
The epidemiological and public health research response to 2009 pandemic influenza A(H1N1): experiences from Hong Kong

In recent years, Hong Kong has invested in research infrastructure to appropriately respond to novel infectious disease epidemics. Research from Hong Kong made a strong contribution to the international response to the 2009 influenza A (H1N1) pandemic (pH1N1). Summarizing, describing, and reviewing Hong Kong’s response to the 2009 pandemic, this article aimed to identify key elements of a real‐time research response. A systematic search in PubMed and EMBASE for research into the infection dynamics and natural history, impact, or control of pH1N1 in Hong Kong. Eligible articles were analyzed according to their scope. Fifty‐five articles were included in the review. Transmissibility of pH1N1 was similar in Hong Kong to elsewhere, and only a small fraction of infections were associated with severe disease. School closures were effective in reducing pH1N1 transmission, oseltamivir was effective for treatment of severe cases while convalescent plasma therapy has the potential to mitigate future pandemics. There was a rapid and comprehensive research response to pH1N1 in Hong Kong, providing important information on the epidemiology of the novel virus with relevance internationally as well as locally. The scientific knowledge gained through these detailed studies of pH1N1 is now being used to revise and update pandemic plans. The experiences of the research response in Hong Kong could provide a template for the research response to future emerging and reemerging disease epidemics.
Large-scale software engineering questions expert opinion or empirical evidence?

A recent report on the state of the UK information technology (IT) industry based most of its findings and recommendations on expert opinion. It is surprising that the report was unable to incorporate more empirical evidence. This paper aims to assess whether it is necessary to base IT industry and academic policy on expert opinion rather than on empirical evidence. Current evidence related to the rate of project failure is identified and the methods used to accumulate that evidence discussed. This shows that the report failed to identify relevant evidence and most evidence related to project failure is based on convenience samples. The status of empirical research in the computing disciplines is reviewed showing that empirical evidence covers a restricted range of subjects and seldom addresses the 'Society' level of analysis. Other more robust designs that would address large-scale IT questions are discussed. We recommend adopting a more systematic approach to accumulating and reporting evidence. In addition, we propose using quasi-experimental designs developed and used in the social sciences to improve the methodology used for undertaking large-scale empirical studies in software engineering.
RETRACTED – Intra-individual Cognitive Variability: An Examination of ANAM4 TBI-MIL Simple Reaction Time Data from Service Members with and without Mild Traumatic Brain Injury

Abstract Objectives: The Automated Neuropsychological Assessment Metrics 4 TBI-MIL (ANAM4) is a computerized cognitive test often used in post-concussion assessments with U.S. service members (SMs). Existing evidence, however, remains mixed regarding ANAM4’s ability to identify cognitive issues following mild traumatic brain injury (mTBI). Studies typically examine ANAM4 by comparing mean scores to baseline or normative scores. A more fine-grained approach involves examining inconsistency within an individual’s performance. Methods: Data from a sample of 231 were healthy control SMs and 100 SMs within 7 days of mTBI who took the ANAM4 were included in analyses. We examine each individual’s performance on a simple reaction time (SRT) subtest that is administered at the beginning (SRT1) and end (SRT2) of the ANAM4 battery, and calculate the standard deviation of difference scores by trial across administrations. Results: Multivariate analysis of variance and univariate analyses revealed group differences across all comparisons (p<.001) with pairwise comparisons revealing higher intra-individual variability and slower raw reaction time for the mTBI group compared with controls. Effect sizes were small though exceeded the recommended minimum practical effect size (ES>0.41). Conclusions: While inconsistencies in performance are often viewed as noise or test error, the results suggest intra-individual cognitive variability may be more sensitive than central tendency measures (i.e., comparison of means) in detecting changes in cognitive function in mTBI. Additionally, the findings highlight the utility of ANAM4’s repeating a subtest at two points in a battery to explore within-subject differences in performance. (JINS, 2017, 23, 1–6)
Exploring the Relationship between Affect and Sensory Processing Patterns in Adults

Purpose: Growing evidence exists regarding the relationship between sensory processing and affective disorders. However, most of this evidence relates to children. This study aimed to explore the relationship between positive/negative affect and sensory processing patterns as expressed in daily situations among healthy adults. Procedure: Two hundred and thirteen healthy individuals aged 18–50 years completed the Adolescent/Adult Sensory Profile (AASP) and the Positive and Negative Affect Schedule (PANAS). Results: Negative affect correlated positively with Sensory Sensitivity, Sensation Avoiding and Low Registration. Positive affect correlated with Sensation Seeking. Conclusion: Sensory processing patterns might be related to the person's affect. In practical terms, this relationship among typical individuals suggests that people could benefit from knowledge about the impact of their sensory processing patterns on everyday life or, in some cases, from occupational therapy intervention. Nevertheless, further studies are needed to elucidate this relationship and its impacts on participation, quality of life and wellbeing.
ALEA: Fine-Grain Energy Profiling with Basic Block Sampling

Energy efficiency is an essential requirement for all contemporary computing systems. We thus need tools to measure the energy consumption of computing systems and to understand how workloads affect it. Significant recent research effort has targeted direct power measurements on production computing systems using on-board sensors or external instruments. These direct methods have in turn guided studies of software techniques to reduce energy consumption via workload allocation and scaling. Unfortunately, direct energymeasurementsarehamperedbythelowpowersampling frequency of power sensors. The coarse granularity of power sensing limits our understanding of how power is allocated in systems and our ability to optimize energy efficiency via workload allocation. We present ALEA, a tool to measure power and energy consumption at the granularity of basic blocks, using a probabilistic approach. ALEA provides fine-grained energy profiling via statistical sampling, which overcomes the limitations of power sensing instruments. Compared to state-of-the-art energy measurement tools, ALEA provides finer granularity without sacrificing accuracy. ALEA achieves low overhead energy measurements with mean error rates between 1.4% and 3.5% in 14 sequential and parallel benchmarks tested on both Intel and ARM platforms. The sampling method caps execution time overhead at approximately 1%. ALEA is thus suitable for online energy monitoring and optimization. Finally, ALEA is a user-space tool with a portable, machine-independent sampling method. We demonstrate three use cases of ALEA, where we reduce the energy consumption of a k-means computational kernel by 37%, an ocean modeling code by 33%, and a ray tracing code by 6% compared to high-performance execution baselines, by varying the power optimization strategy between basic blocks.
Cell cycle regulators and outcome of adjuvant cisplatin-based chemotherapy in completely resected non-small-cell lung cancer: the International Adjuvant Lung Cancer Trial Biologic Program.

PURPOSE The International Adjuvant Lung Cancer Trial (IALT) demonstrated that adjuvant cisplatin-based chemotherapy improves the survival of patients with completely resected non-small-cell lung cancer (NSCLC). The purpose of our study was to determine whether cell cycle regulators are of prognostic and/or predictive value in patients who were enrolled onto the IALT. PATIENTS AND METHODS Expression of p27Kip1, p16INK4A, cyclin D1, cyclin D3, cyclin E, and Ki-67 was immunohistochemically assessed in tumor specimens obtained from 778 IALT patients. Prognostic and predictive analyses were based on Cox models adjusted for clinical and pathologic parameters. RESULTS There was a relationship between p27Kip1 status and benefit of cisplatin-based chemotherapy (test for interaction, P = .02). Among patients with p27Kip1-negative tumors, cisplatin-based chemotherapy resulted in longer overall survival compared with controls (adjusted hazard ratio [HR] for death = 0.66; 95% CI, 0.50 to 0.88; P = .006). In patients with p27Kip1-positive tumors, overall survival was not different between patients treated with cisplatin-based chemotherapy and controls (adjusted HR for death = 1.09; 95% CI, 0.82 to 1.45; P = .54). The other cell cycle regulators and Ki-67 did not predict benefit of adjuvant cisplatin-based chemotherapy. None of these biomarkers was significantly associated with overall survival of the patients in the total study population. CONCLUSION NSCLC patients with p27Kip1-negative tumors benefit from adjuvant cisplatin-based chemotherapy after complete tumor resection. Before establishing p27Kip1 as a routine marker for selection of patients for adjuvant chemotherapy, the predictive value of p27Kip1 has to be confirmed in patients from other trials.
Influence of mountain waves and NAT nucleation mechanisms on polar stratospheric cloud formation at local and synoptic scales during the 1999 – 2000 Arctic winter

A scheme for introducing mountain wave-induced temperature pertubations in a microphysical PSC model has been developed. A data set of temperature fluctuations attributable to mountain waves as computed by the Mountain Wave Forecast Model (MWFM-2) has been used for the study. The PSC model has variable microphysics, enabling different nucleation mechanisms for nitric acid trihydrate, NAT, to be employed. In particular, the difference between the formation of NAT and ice particles in a scenario where NAT formation is not dependent on preexisting ice particles, allowing NAT to form at temperatures above the ice frost point,Tice, and a scenario, where NAT nucleation is dependent on preexisting ice particles, is examined. The performance of the microphysical model in the different microphysical scenarios and a number of temperature scenarios with and without the influence of mountain waves is tested through comparisons with lidar measurements of PSCs made from the NASA DC-8 on 23 and 25 January during the SOLVE/THESEO 2000 campaign in the 1999–2000 winter and the effect of mountain waves on local PSC production is evaluated in the different microphysical scenarios. Mountain waves are seen to have a pronounced effect on the amount of ice particles formed in the simulations. Quantitative comparisons of the amount of solids seen in the observations and the amount of solids produced in the simulations show the best correspondence when NAT formation is allowed to take place at temperatures above Tice. Mountain wave-induced temperature fluctuations are introduced in vortex-covering model runs, extending the full 1999–2000 winter season, and the effect of mountain waves on large-scale PSC production is estimated in the different microphysical scenarios. It is seen Correspondence to: S.H. Svendsen (shs@dmi.dk) that regardless of the choice of microphysics ice particles only form as a consequence of mountain waves whereas NAT particles form readily as a consequence of the synoptic conditions alone if NAT nucleation above Tice is included in the simulations. Regardless of the choice of microphysics, the inclusion of mountain waves increases the amount of NAT particles by as much as 10%. For a given temperature scenario the choice of NAT nucleation mechanism may alter the amount of NAT substantially; three-fold increases are easily found when switching from the scenario which requires preexisting ice particles in order for NAT to form to the scenario where NAT forms independently of ice.
An outcome evaluation of the SOS Suicide Prevention Program.

OBJECTIVES We examined the effectiveness of the Signs of Suicide (SOS) prevention program in reducing suicidal behavior. METHODS Twenty-one hundred students in 5 high schools in Columbus, Ga, and Hartford, Conn, were randomly assigned to intervention and control groups. Self-administered questionnaires were completed by students in both groups approximately 3 months after program implementation. RESULTS Significantly lower rates of suicide attempts and greater knowledge and more adaptive attitudes about depression and suicide were observed among students in the intervention group. The modest changes in knowledge and attitudes partially explained the beneficial effects of the program. CONCLUSIONS SOS is the first school-based suicide prevention program to demonstrate significant reductions in self-reported suicide attempts.