Miracle-dz/UniFAR-FTUs huggingface dataset:
Small Tails Tell Tall Tales – Intra-Individual Variation in the Stable Isotope Values of Fish Fin

Background Fish fin is a widely used, non-lethal sample material in studies using stable isotopes to assess the ecology of fishes. However, fish fin is composed of two distinct tissues (ray and membrane) which may have different stable isotope values and are not homogeneously distributed within a fin. As such, estimates of the stable isotope values of a fish may vary according to the section of fin sampled. Methods To assess the magnitude of this variation, we analysed carbon (δ 13C), nitrogen (δ 15N), hydrogen (δ 2H) and oxygen (δ 18O) stable isotopes of caudal fin from juvenile, riverine stages of Atlantic salmon (Salmo salar) and brown trout (Salmo trutta). Individual fins were sub-sectioned into tip, mid and base, of which a further subset were divided into ray and membrane. Findings Isotope variation between fin sections, evident in all four elements, was primarily related to differences between ray and membrane. Base sections were13C depleted relative to tip (~ 1 ‰) with equivalent variation evident between ray and membrane. A similar trend was evident in δ 2H, though the degree of variation was far greater (~ 10 ‰). Base and ray sections were 18O enriched (~ 2 ‰) relative to tip and membrane, respectively. Ray and membrane sections displayed longitudinal variation in 15N mirroring that of composite fin (~ 1 ‰), indicating that variation in15N values was likely related to ontogenetic variation. Conclusions To account for the effects of intra-fin variability in stable isotope analyses we suggest that researchers sampling fish fin, in increasing priority, 1) also analyse muscle (or liver) tissue from a subsample of fish to calibrate their data, or 2) standardize sampling by selecting tissue only from the extreme tip of a fin, or 3) homogenize fins prior to analysis.
Desorption electrospray ionization mass spectrometry: Imaging drugs and metabolites in tissues

Ambient ionization methods for MS enable direct, high-throughput measurements of samples in the open air. Here, we report on one such method, desorption electrospray ionization (DESI), which is coupled to a linear ion trap mass spectrometer and used to record the spatial intensity distribution of a drug directly from histological sections of brain, lung, kidney, and testis without prior chemical treatment. DESI imaging provided identification and distribution of clozapine after an oral dose of 50 mg/kg by: i) measuring the abundance of the intact ion at m/z 327.1, and ii) monitoring the dissociation of the protonated drug compound at m/z 327.1 to its dominant product ion at m/z 270.1. In lung tissues, DESI imaging was performed in the full-scan mode over an m/z range of 200-1100, providing an opportunity for relative quantitation by using an endogenous lipid to normalize the signal response of clozapine. The presence of clozapine was detected in all tissue types, whereas the presence of the N-desmethyl metabolite was detected only in the lung sections. Quantitation of clozapine from the brain, lung, kidney, and testis, by using LC-MS/MS, revealed concentrations ranging from 0.05 μg/g (brain) to a high of 10.6 μg/g (lung). Comparisons of the results recorded by DESI with those by LC-MS/MS show good agreement and are favorable for the use of DESI imaging in drug and metabolite detection directly from biological tissues.
Analysis of free-edge stress and displacement fields in scarf joints subjected to a uniform change in temperature

The role of free-edge stresses in controlling the initiation of failure from the interface corner of a scarf joint subjected to a uniform change in temperature is examined. In general, the stress field can be expressed by σ ij = Hr λ-1 + σ ijo , where r is the radial distance from the interface corner, λ-1 is the order of the stress singularity, H is the intensity of the singularity, and σ ijo is a non-singular constant stress. A combination of the finite element method and a path-independent integral is used to evaluate the magnitude of H for two joint configurations: (i) a scarf joint between two long bi-material strips; and (ii) a scarf joint consisting of a thin elastic layer sandwiched between two substrates. The magnitude of H is linearly dependent on a non-dimensional constant function a; the magnitude of a decreases with increasing level of mismatch in the elastic properties of the bonded materials. A comparison between the values of H evaluated by the path-independent integral method and the commonly used extrapolation method indicate that the extrapolation method could be in error by as much as 25%.
R&D on Composition and Processing of Titanium Aluminide Alloys for Turbine Engines

Abstract : In this current program, one alpha-two and several gamma compositions were selected, produced as large ingots and isothermally forged. Extensive mechanical property testing was conducted on these forgings. In addition, various material processing methods such as casting, rolling, extrusion and machining were evaluated. The alpha-two alloy Ti-25Al-10Nb-3V-1Mo exhibited the best balance of tensile and stress-rupture properties found to date and had a higher elastic modulus. Beta grain size was shown to have major effects on creep, low cycle fatigue and fracture toughness. Alloy stability, as measured by post-exposure tensile ductility, was poor and was tentatively traced to precipitation of an unidentified phase in the beta. Heat treatment modifications were suggested to alleviate this problem. Processing studies showed that many of the methods developed for forging, joining and rolling of conventional titanium alloys can be applied to the alpha-two alloys. Screening tests conducted on four gamma alloys did not identify an alloy with a better property balance than Ti- 48Al-1V-. 1C which had been evaluated previously. Properties were more consistent with previous small scale ingots, although ductility and impact strength were somewhat lower, and quite good toughness levels were measured. Alloy stability was excellent after exposure and processing studies established machining procedures and demonstrated and demonstrated that the alloy has fair castability.
Retinoic acid regulates postnatal neurogenesis in the murine subventricular zone-olfactory bulb pathway

Neurogenesis persists throughout life in the rodent subventricular zone (SVZ)-olfactory bulb pathway. The molecular regulation of this neurogenic circuit is poorly understood. Because the components for retinoid signaling are present in this pathway, we examined the influence of retinoic acid (RA) on postnatal SVZ-olfactory bulb neurogenesis. Using both SVZ neurosphere stem cell and parasagittal brain slice cultures derived from postnatal mouse, we found that RA exposure increased neurogenesis by enhancing the proliferation and neuronal differentiation of forebrain SVZ neuroblasts. The RA precursor retinol had a similar effect, which was reversed by treating cultures with the RA synthesis inhibitor disulfiram. Electroporation of dominant-negative retinoid receptors into the SVZ of slice cultures also blocked neuroblast migration to the olfactory bulb and altered the morphology of the progenitors. Moreover, the administration of disulfiram to neonatal mice decreased in vivo cell proliferation in the striatal SVZ. These results indicate that RA is a potent mitogen for SVZ neuroblasts and is required for their migration to the olfactory bulb. The regulation of multiple steps in the SVZ-olfactory bulb neurogenic pathway by RA suggests that manipulation of retinoid signaling is a potential therapeutic strategy to augment neurogenesis after brain injury.
A Compact Representation Scheme for Coalitional Games in Open Anonymous Environments

Coalition formation is an important capability of automated negotiation among self-interested agents. In order for coalitions to be stable, a key question that must be answered is how the gains from cooperation are to be distributed. Recent research has revealed that traditional solution concepts, such as the Shapley value, core, least core, and nucleolus, are vulnerable to various manipulations in open anonymous environments such as the Internet. These manipulations include submitting false names, collusion, and hiding some skills. To address this, a solution concept called the anonymity-proof core, which is robust against such manipulations, was developed. However, the representation size of the outcome function in the anonymity-proof core (and similar concepts) requires space exponential in the number of agents/skills. This paper proposes a compact representation of the outcome function, given that the characteristic function is represented using a recently introduced compact language that explicitly specifies only coalitions that introduce synergy. This compact representation scheme can successfully express the outcome function in the anonymity-proof core. Furthermore, this paper develops a new solution concept, the anonymity-proof nucleolus, that is also expressible in this compact representation. We show that the anonymity-proof nucleolus always exists, is unique, and is in the anonymity-proof core (if the latter is nonempty). and assigns the same value to symmetric skills.
Circulating Leukotriene B4 Identifies Respiratory Complications after Trauma

Background. Leukotriene B4 (LTB4), a proinflammatory lipid mediator correlates well with the acute phase of Acute Respiratory Distress Syndrome (ARDS). Therefore, LTB4-levels were investigated to determine whether they might be a useful clinical marker in predicting pulmonary complications (PC) in multiply traumatized patients. Methods: Plasma levels of LTB4 were determined in 100 patients on admission (ED) and for five consecutive days (daily). Twenty healthy volunteers served as control. LTB4-levels were measured by ELISA. Thirty patients developed PC (pneumonia, respiratory failure, acute lung injury (ALI), ARDS, pulmonary embolism) and 70 had no PC (ØPC). Results. LTB4-levels in the PC-group [127.8 pg/mL, IQR: 104–200pg/ml] were significantly higher compared to the ØPC-group on admission [95.6 pg/mL, IQR: 55–143 pg/mL] or control-group [58.4 pg/mL, IQR: 36–108 pg/mL]. LTB4 continuously declined to basal levels from day 1 to 5 without differences between the groups. The cutoff to predict PC was calculated at 109.6 pg/mL (72% specificity, 67% sensitivity). LTB4 was not influenced by overall or chest injury severity, age, gender or massive transfusion. Patients with PC received mechanical ventilation for a significantly longer period of time, and had prolonged intensive care unit and overall hospital stay. Conclusion. High LTB4-levels indicate risk for PC development in multiply traumatized patients.
Controlled Surface Flaws in Hot‐Pressed SiC

Controlled semi-elliptical surface flaws were produced in hot-pressed SiC by Knoop microhardness indentation. Flawed specimens were placed in 4-point bending in order to determine their critical stress intensity factor, KIC, at both room and high temperatures. Room-temperature fracture and KIC values after annealing were sensitive to the annealing environment; this behavior correlated with the active/passive nature of the oxidation process. Flaw healing was observed for annealing exposures in air. Room-temperature KIC values increased with increasing annealing temperature. High-temperature KICvalues decreased with increasing temperature as a result of a decrease in the fracture surface energy.
Reasoning about Expectation

Expectation is a central notion in probability theory. The notion of expectation also makes sense for other notions of uncertainty. We introduce a propositional logic for reasoning about expectation, where the semantics depends on the underlying representation of uncertainty. We give sound and complete axiomatizations for the logic in the case that the underlying representation is (a) probability, (b) sets of probability measures, (c) belief functions, and (d) possibility measures. We show that this logic is more expressive than the corresponding logic for reasoning about likelihood in the case of sets of probability measures, but equi-expressive in the case of probability, belief, and possibility. Finally, we show that satisfiability for these logics is NP-complete, no harder than satisfiability for propositional logic.
Conceptual analysis and reductive explanation

Is conceptual analysis required for reductive explanation? If there is no a priori entailment from microphysical truths to phenomenal truths, does reductive explanation of the phenomenal fail? We say yes (Chalmers 1996; Jackson 1994, 1998). Ned Block and Robert Stalnaker say no (Block and Stalnaker 1999). A number of issues can be distinguished: (1) Is there an a priori entailment from microphysical truths to ordinary macroscopic truths? (2) If there is no a priori entailment from microphysical truths to phenomenal truths, does reductive explanation of the phenomenal fail? (3) If there is no a priori entailment from microphysical truths to phenomenal truths, is physicalism about the phenomenal false? (4) Is there an a priori entailment from microphysical truths to phenomenal truths? We hold that the first three questions should be answered positively (with some qualifications to be outlined). Block and Stalnaker hold that the first three questions should be answered negatively. Their central strategy is to argue for a negative answer to the first question, and to use this conclusion to argue for a negative answer to the second and third questions. They argue that truths about water and about life, for example, are not entailed a priori by microphysical truths, but that this is no bar to the reductive explanation and physical constitution of water and of life. In this paper, we will address Block and Stalnaker's arguments for a negative answer to the first three questions, while remaining neutral on the fourth. We will proceed by first giving an independent defense of a positive answer to the first question. This makes the ensuing reply to Block and Stalnaker more straightforward, and also makes the discussion accessible to those unfamiliar with the literature.
Automatic Record Reviews

Record reviews provide a unique and focused source of linguistic data that can be related to musical recordings, to provide a basis for computational music understanding systems with applications in similarity, recommendation and classification. We analyze a large testbed of music and a corpus of reviews for each work to uncover patterns and develop mechanisms for removing reviewer bias and extraneous non-musical discussion. By building upon work in grounding free text against audio signals we invent an “automatic record review” system that labels new music audio with maximal semantic value for future retrieval tasks. In effect, we grow an unbiased music editor trained from the consensus of the online reviews we have gathered.
Quantitative field theory of the glass transition

We develop a full microscopic replica field theory of the dynamical transition in glasses. By studying the soft modes that appear at the dynamical temperature, we obtain an effective theory for the critical fluctuations. This analysis leads to several results: we give expressions for the mean field critical exponents, and we analytically study the critical behavior of a set of four-points correlation functions, from which we can extract the dynamical correlation length. Finally, we can obtain a Ginzburg criterion that states the range of validity of our analysis. We compute all these quantities within the hypernetted chain approximation for the Gibbs free energy, and we find results that are consistent with numerical simulations.
The acidic amino-terminal region of herpes simplex virus type 1 alpha protein ICP27 is required for an essential lytic function

The herpes simplex virus type 1 (HSV-1) alpha protein ICP27 regulates the transition between the delayed-early and late phases of the viral infection. Previous genetic analyses have suggested that the important functional domains of ICP27 map to its carboxyl-terminal half. One striking feature of the primary sequence of ICP27, however, is an extremely acidic region near its amino terminus. To determine whether this region is required for ICP27 function, we deleted the sequences in the ICP27 gene which encode it (codons 12 through 63). In transient expression assays, the deletion mutant was unable to efficiently repress the expression of a cotransfected reporter gene or to efficiently complement the growth of d27-1, an HSV-1 ICP27 null mutant. These results suggested that the acidic region of ICP27 is involved in a regulatory function required for lytic growth. To test this possibility further, we introduced the mutant allele into the HSV-1 genome by marker transfer. Two independently derived isolates of the mutant virus, designated d1-2a and d1-2b, were recovered and analyzed. Both isolates were defective for growth in Vero cells, exhibiting a 100-fold reduction in virus yield compared with the wild-type infection. Vero cells infected with the d1-2 isolates showed a three- to eightfold reduction in viral DNA replication, a moderate reduction in the expression of viral gamma genes, and a delay in the repression of beta genes. The phenotype of the d1-2 isolates differs substantially from the phenotypes of previously isolated ICP27 mutants, which show much more severe defects in viral gene expression. Our results demonstrate that the amino-terminal half of ICP27 participates in its regulatory activities in both infected and transfected cells.
Italian mediterranean index and risk of colorectal cancer in the Italian section of the EPIC cohort

Colorectal cancer is among the commonest cancers worldwide. Dietary factors have been linked to colorectal cancer risk, however, few studies have evaluated the relationship between a priori dietary patterns and colorectal cancer risk. We evaluated the effect of adherence to a Mediterranean dietary pattern, as measured by the Italian Mediterranean Index, on the risk of colorectal cancer in the 45,275 participants of the Italian section of the EPIC study who completed a dietary questionnaire. Hazard ratios (HRs) with 95% confidence intervals (CIs) for colorectal cancer in relation to categories of Italian Mediterranean Index score were estimated by multivariate Cox models adjusted for known risk factors, on the whole cohort, on men and women and according to cancer subsite. During a mean follow‐up of 11.28 years, 435 colorectal cancer cases were identified. The Italian Mediterranean Index was inversely associated with colorectal cancer risk (HR: 0.50; 95% CI: 0.35–0.71 for the highest category compared to the lowest, P‐trend: 0.043). Results did not differ by sex. Highest Italian Mediterranean Index score was also significantly associated with reduced risks of any colon cancer (HR: 0.54, 95% CI: 0.36–0.81), distal colon cancer (HR: 0.44, 95% CI: 0.26–0.75) and rectal cancer (HR: 0.41, 95% CI: 0.20–0.81), but not of proximal colon cancer. These findings suggest that adherence to a Mediterranean diet (as measured by the Italian Mediterranean Index) protects against colorectal cancer in general but not against cancer developing in the proximal colon.
Novel therapeutic strategy for osteosarcoma targeting osteoclast differentiation, bone-resorbing activity, and apoptosis pathway

Osteosarcoma is the most common bone sarcoma, which mainly affects adolescents and young adults. Although the combination of modern surgery and systemic chemotherapy has improved osteosarcoma treatment dramatically, no substantial change in survival has been seen over the past 20 years. Therefore, novel therapeutic strategies for osteosarcoma are required if the 35% of patients with fatal metastases are to be successfully treated. Recently, osteoclasts have drawn attention as a therapeutic target in various bone disorders including osteosarcoma. The osteoclast is the sole cell that resorbs bone and is central in pathologic situations, where bone destruction is intricately involved. Osteosarcoma cells are of the osteoblastic lineage, the latter of which is characterized by cells secreting the osteoclast-inducing factor, receptor activator of nuclear factor-κB ligand. Hence, osteosarcoma is a better candidate for osteoclast-targeted therapy than other primary and metastatic bone tumors. The rapid progress on the molecular mechanism regulating osteoclast has propelled a development of new therapeutic approaches. In this review article, we present the prospects of osteoclast-targeted therapy as a novel treatment strategy for osteosarcoma. Receptor activator of nuclear factor-κB-Fc, osteoprotegerin, bisphosphonates, and Src inhibitor are shown as positive candidates and can control various aspects of osteoclast function. This review article will attempt to discuss these issues in term. [Mol Cancer Ther 2008;7(11):3461–9]
A THREE-DIMENSIONAL KINEMATIC ANALYSIS OF THE VOLLEYBALL JUMP SERVE

INTRODUCTION The aim of this study was to describe and analyse biomechanically the actions used by international volleyball players performing the jump (spike) serve. Although attack spiking has been studied in detail (for example Coleman et al, 1993), there has been no research comparing the techniques with those required for successful jump serving. METHODS Eleven International players (Great Britain) were filmed in competition and training using two gen-locked video cameras filming at 50Hz. Three-dimensional object space co-ordinates of digitized image co-ordinates were then obtained using a DLT algorithm and an array of calibration points in the filmed volume using software written by Bartlett (1990). Relationships between lower limb angular kinematics, centre of mass velocities and vertical displacement were analysed. Associations between upper limb kinematics, trunk angular movements and post-impact ball speeds were also examined using Pearson Product Moment Correlations. RESULTS Centre of Mass (CM) vertical and horizontal take-off velocities were equal in magnitude (2.76 m.s-l), and there was no significant correlation with any of the lower limb angular kinematics. Jump heights (CM vertical displacements) were significantly correlated to the square of the CM vertical take-off velocities (r = 0.74, P = 0.005), but not to lower limb variables. Mean post-impact ball speeds were 23.7+2.lm.s-1 and were only significantly associated with the hitting hand speed (r = 0.66, P = 0.013) and maximum humerus-trunk angular velocity (r = 0.55, P = 0.041). Trunk rotational kinematics did not correlate significantly with ball speeds. CONCLUSIONS The results from this study concerning simple relationships between limb kinematics and performance variables during the jump serve confirmed the research of Coleman et al(1993). CM horizontal velocities and displacements were higher than those reported for spiking, reflecting the linear translation required in the jump serve. It is intended that the results obtained from this study will be used in a mathematical model (such as those which have been developed for the spike) to examine tactical effectiveness. REFERENCES Bartlett, R.M. (1990). The definition, design, implementation and use of a comprehensive software package for the Acorn Archimedes A440 microcomputer. Communication to the XIII International Symposium of Biomechanics in Sports, Prague. Coleman, S.G. S. , Benharn, A.S. , Northcott, S.R. (1993) A three-dimensional cinematographical analysis of the volleyball spike. Journal of Sports Sciences, 11, 295-302.