Miracle-dz/UniFAR-FTUs huggingface dataset:
Healthcare providers’ understanding of HIV serodiscordance in South Africa and Uganda: implications for HIV prevention in sub-Saharan Africa

HIV transmission within stable heterosexual HIV serodiscordant couples accounts for almost half the new incident infections in South Africa and Uganda. Advances in HIV prevention provide opportunities to reduce transmission risk within serodiscordant partnerships (e.g., antiretroviral treatment (ART), pre-exposure prophylaxis (PrEP), medical male circumcision, and couples-based HIV counselling and testing). These interventions require a clinical encounter with a provider who recognises prevention opportunities within these partnerships. We explored healthcare provider understanding of HIV serodiscordance in a reproductive counselling study with providers in eThekwini district, South Africa, and Mbarara district, Uganda. In eThekwini, in-depth interviews (29) and focus group discussions (2) were conducted with 42 providers (counsellors, nurses and doctors) from public sector clinics. In Mbarara, in-depth interviews were conducted with 38 providers (medical officers, clinical officers, nurses, peer counsellors and village health workers). Thematic analysis was conducted using NVivo software. In eThekwini, many providers assumed HIV seroconcordance among client partners and had difficulty articulating how serodiscordance occurs. Mbarara providers had a better understanding of HIV serodiscordance. In the two countries, providers who understood HIV serodiscordance were better able to describe useful HIV-prevention strategies. Healthcare providers require training and support to better understand the prevalence and mechanisms of HIV serodiscordance to implement HIV-prevention strategies for HIV serodiscordant couples.
Global Distribution and Trends of Tropospheric Ozone: An Observation-Based Review

Tropospheric ozone plays a major role in Earth’s atmospheric chemistry processes and also acts as an air pollutant and greenhouse gas. Due to its short lifetime, and dependence on sunlight and precursor emissions from natural and anthropogenic sources, tropospheric ozone’s abundance is highly variable in space and time on seasonal, interannual and decadal time-scales. Recent, and sometimes rapid, changes in observed ozone mixing ratios and ozone precursor emissions inspired us to produce this up-to-date overview of tropospheric ozone’s global distribution and trends. Much of the text is a synthesis of in situ and remotely sensed ozone observations reported in the peer-reviewed literature, but we also include some new and extended analyses using well-known and referenced datasets to draw connections between ozone trends and distributions in different regions of the world. In addition, we provide a brief evaluation of the accuracy of rural or remote surface ozone trends calculated by three state-of-the-science chemistry-climate models, the tools used by scientists to fill the gaps in our knowledge of global tropospheric ozone distribution and trends.
The trend of changes in the evaluation scores of faculty members from administrators’ and students’ perspectives at the medical school over 10 years

Aim To assess the trend of changes in the evaluation scores of faculty members and discrepancy between administrators’ and students’ perspectives in a medical school from 2006 to 2015. Materials and methods This repeated cross-sectional study was conducted on the 10-year evaluation scores of all faculty members of a medical school (n=579) in an urban area of Iran. Data on evaluation scores given by students and administrators and the total of these scores were evaluated. Data were analyzed using descriptive and inferential statistics including linear mixed effect models for repeated measures via the SPSS software. Results There were statistically significant differences between the students’ and administrators’ perspectives over time (p<0.001). The mean of the total evaluation scores also showed a statistically significant change over time (p<0.001). Furthermore, the mean of changes over time in the total evaluation score between different departments was statistically significant (p<0.001). Conclusion The trend of changes in the student’s evaluations was clear and positive, but the trend of administrators’ evaluation was unclear. Since the evaluation of faculty members is affected by many other factors, there is a need for more future studies.
Grounding ethnographic content analysis, etic as well as emic strategies; a study of context for instructional designers

Parallels were realized between Krippendorff’s (2004) validity evidence for content analysis and Fereday and MuirCochrane’s (2006) interpretation of Schultz’s (1967) postulates for increasing rigor within the examination of social phenomenon. In order to increase empirical validity of content analyses Krippendorff (2004) suggested concentrat­ ing on the structure of the analysis, validity of the data, and the relational aspects of the findings. Fereday and MuirCochrane introduced a step-by-step analysis process containing deductive and inductive coding, allowing their re­ search to begin grounded and then progress to a thematic, data-driven discovery. Ethnographic Content Analysis (Altheide, 1987) disregards a priori coding as a quantitative characteristic; however, the etic (and emic) quality of the Fereday & Muir-Cochrane methodology adds grounding and structure to ECA without disrupting the discovery, de­ scriptive nature of the methodology. Instructional designers must be familiar with the characteristics and relationships of context when designing for context-based learning environments. No design or analysis models exist that account for the variable relationships of context. ATLAS.ti® provided the capacity, foundation, and modeling to support both etic and emic qualities and validity evidence through an ECA of internet job postings identifying and modeling con­ textual elements and their relationships.
A comparison of non-verbal creativity between Lithuanian and Mexican adolescents

Background . The purpose of this work was to explore non-verbal creativity (free from language influences) between Mexican and Lithuanian adolescents. Methods . This is a cross comparative study of 354 high school students (average age 17.2 years) from Lithuania and Mexico who were asked to complete four tasks from the 2 non-verbal sections of the Multifactorial assessment of creativity test, EMUC ( Evaluacion Multifactorial de la Creatividad , Sanchez, Garcia, Valdes, 2009). The first section explored visual-spatial creativity associated with vocational choices such as architecture and graphic design. The second explored inventive associated with realistic vocational choices such as engineering and practical handcraft. Results . No significant differences were noticed in the procedures of administering, interpreting and using test results in these two countries. In general, Lithuanians show more fluidity and flexibility, whereas Mexicans show more originality. Results indicated a poor relationship between high creative potential and vocational choices that demand creativity (i.e. design, music, etc.). Consistent gender differences were observed depending upon the type of creativity assessed. Women showed higher creativity on visual-spatial tasks, while men in originality for inventive tasks. Conclusions. Results underline the difficulties in assessing and comparing creative products from different cultures. They underline the importance of context specific criteria to judge creativity in an ipsative fashion. Furthermore, overall results suggest that visual-spatial tasks in this age range should focus on originality and elaboration, whereas the ingenuity task should focus on flexibility and fluidity.
LISA: Increasing Internal Connectivity in DRAM for Fast Data Movement and Low Latency

This paper summarizes the idea of Low-Cost Interlinked Subarrays (LISA), which was published in HPCA 2016, and examines the work's significance and future potential. Contemporary systems perform bulk data movement movement inefficiently, by transferring data from DRAM to the processor, and then back to DRAM, across a narrow off-chip channel. The use of this narrow channel results in high latency and energy consumption. Prior work proposes to avoid these high costs by exploiting the existing wide internal DRAM bandwidth for bulk data movement, but the limited connectivity of wires within DRAM allows fast data movement within only a single DRAM subarray. Each subarray is only a few megabytes in size, greatly restricting the range over which fast bulk data movement can happen within DRAM. Our HPCA 2016 paper proposes a new DRAM substrate, Low-Cost Inter-Linked Subarrays (LISA), whose goal is to enable fast and efficient data movement across a large range of memory at low cost. LISA adds low-cost connections between adjacent subarrays. By using these connections to interconnect the existing internal wires (bitlines) of adjacent subarrays, LISA enables wide-bandwidth data transfer across multiple subarrays with little (only 0.8%) DRAM area overhead. As a DRAM substrate, LISA is versatile, enabling a variety of new applications. We describe and evaluate three such applications in detail: (1) fast inter-subarray bulk data copy, (2) in-DRAM caching using a DRAM architecture whose rows have heterogeneous access latencies, and (3) accelerated bitline precharging by linking multiple precharge units together. Our extensive evaluations show that each of LISA's three applications significantly improves performance and memory energy efficiency on a variety of workloads and system configurations.
Biological Effects Within No-Take Marine Reserves: A global Synthesis

The study and implementation of no-take marine reserves have increased rapidly over the past decade, providing ample data on the biological effects of reserve protection for a wide range of geographic locations and organisms. The plethora of new studies affords the opportunity to re- evaluate previous findings and address formerly unanswered questions with extensive data synthe- ses. Our results show, on average, positive effects of reserve protection on the biomass, numerical density, species richness, and size of organisms within their boundaries which are remarkably simi- lar to those of past syntheses despite a near doubling of data. New analyses indicate that (1) these results do not appear to be an artifact of reserves being sited in better locations; (2) results do not appear to be driven by displaced fishing effort outside of reserves; (3) contrary to often-made asser- tions, reserves have similar if not greater positive effects in temperate settings, at least for reef ecosystems; (4) even small reserves can produce significant biological responses irrespective of lati- tude, although more data are needed to test whether reserve effects scale with reserve size; and (5) effects of reserves vary for different taxonomic groups and for taxa with various characteristics, and not all species increase in response to reserve protection. There is considerable variation in the responses documented across all the reserves in our data set — variability which cannot be entirely explained by which species were studied. We suggest that reserve characteristics and context, par- ticularly the intensity of fishing outside the reserve and inside the reserve before implementation, play key roles in determining the direction and magnitude of the reserve response. However, despite considerable variability, positive responses are far more common than no differences or negative responses, validating the potential for well designed and enforced reserves to serve as globally important conservation and management tools.
The Marmoset as an Animal Model of Influenza: Infection With A(H1N1)pdm09 and Highly Pathogenic A(H5N1) Viruses via the Conventional or Tracheal Spray Route

To control infectious diseases in humans, it is important to understand the pathogenicity of the infecting organism(s). Although non-human primates, such as cynomolgus and rhesus macaques, have been used for influenza virus infection models, their size can limit their use in confined animal facilities. In this study, we investigated the susceptibility of marmosets to influenza viruses to assess the possibility of using these animals as a non-human primate model for influenza research. We first used an influenza A (H1N1)pdm09 virus to compare two inoculation routes: the conventional route, via a combination of the intratracheal, intranasal, ocular, and oral routes; and the tracheal spray route. In marmosets inoculated via the tracheal spray route, we found inflammation throughout the lungs and trachea. In contrast, in marmosets inoculated via the conventional route, the inflammation was confined to roughly the center of the lung. These data suggest that the tracheal spray route may be more suitable than the conventional route to inoculate marmosets with influenza viruses. We also tested an influenza A(H5N1) highly pathogenic avian influenza (HPAI) virus and found that some marmosets inoculated with this virus via the tracheal spray route showed weight loss, decreased body temperature, and loss of appetite and activity. The replication of this H5N1 virus in respiratory organs was confirmed. These results indicate the potential of marmosets as an animal model for infection with seasonal or HPAI viruses.
The relationship between Cyber-Loafing and internet addiction

The goal of this study was to investigate the relationship between preservice teachers’ internet addiction level and cyber-loafing activities. This study was conducted as a survey study. Participants of the study was Computer Education and Instructional Technology department students (n=139) at Ankara University. “Cyber loafing activity Scale” originally developed by Blanchard and Henle (2008), adopted to Turkish by Kalayci (2010) and updated by Yasar (2013) and “Internet Addiction Scale” developed by Sahin and Korkmaz (2011) was used as data collection instruments. To analyze the data descriptive statistics, Mann Whitney U, Kruskal Wallis H, and Spearman Rho Correlation coefficients was used. There were significant differences between the gender groups both in cyber-loafing activities and internet addiction levels. Male preservice teacher had higher internet addiction levels and cyber-loafing activity scores in average. However there were not significant differences between different groups based on grade level, period of internet usage, perceived internet ability, both for cyber-loafing activities and internet addiction levels. There were a moderate positive relationships between internet addiction and individual cyber-loafing, and search cyber-loafing. There were also a small positive relationships between internet addiction and social cyber-loafing. There was not a significant relationship between internet addiction and news cyber-loafing. Keywords: cyber-loafing, internet addiction, preservice teachers
Palpebro-Orbital Apocrine Cystadenoma: Immunohistochemical Verification of a Unique Variant With a Critical Differential Diagnosis

Purpose: To describe a unique apocrine cystadenoma of the superonasal eyelid and anterior orbit. Methods: Clinical evaluation with axial and coronal CT; histopathologic and immunohistochemical studies including sections stained with hematoxylin-eosin, periodic acid Schiff, alcian blue, mucicarmine, and Prussian blue for iron; and monoclonal antibodies against cytokeratin-7, epithelial membrane antigen, smooth muscle actin for myoepithelial cells, gross cystic disease fluid protein-15 for apocrine differentiation, and CD-68 and lysozyme for histiocytes. Results: The cyst possessed a multilaminar lining composed of polygonal to low cuboidal cells. A stalk of solid tumor ingrowth from the wall was composed of adenomatous units of eosinophilic cells with apical snouts (“decapitation secretion”). No goblet cells were discovered. Both the cyst's lining cells and the adenoma expressed gross cystic disease fluid protein-15 indicative of apocrine differentiation. The adenoma displayed inner adlumenal cells that were CK-7 and epithelial membrane antigen positive, and outer myoepithelial cells that were smooth muscle actin positive. Simple local excision was curative. Conclusion: This unique lesion is the first example in the ophthalmic and dermatopathologic literatures of a solid adenoma encompassed by an apocrine cyst, which more typically features short or blunt papillae. It must be distinguished from other eyelid and/or anterior orbital cystic lesions including eccrine hydrocystomas; classical and extratarsal dermoid cysts; congenital and acquired conjunctival cysts and dermoids; dacryocystocoeles/mucoceles; canaliculops and lacrimal gland dacryops; and congenital cystic odontogenic choristomas.
Constraining estimates of global soil respiration by quantifying sources of variability

Quantifying global soil respiration (RSG) and its response to temperature change are critical for predicting the turnover of terrestrial carbon stocks and their feedbacks to climate change. Currently, estimates of RSG range from 68 to 98 Pg C year−1, causing considerable uncertainty in the global carbon budget. We argue the source of this variability lies in the upscaling assumptions regarding the model format, data timescales, and precipitation component. To quantify the variability and constrain RSG, we developed RSG models using Random Forest and exponential models, and used different timescales (daily, monthly, and annual) of soil respiration (RS) and climate data to predict RSG. From the resulting RSG estimates (range = 66.62–100.72 Pg), we calculated variability associated with each assumption. Among model formats, using monthly RS data rather than annual data decreased RSG by 7.43–9.46 Pg; however, RSG calculated from daily RS data was only 1.83 Pg lower than the RSG from monthly data. Using mean annual precipitation and temperature data instead of monthly data caused +4.84 and −4.36 Pg C differences, respectively. If the timescale of RS data is constant, RSG estimated by the first‐order exponential (93.2 Pg) was greater than the Random Forest (78.76 Pg) or second‐order exponential (76.18 Pg) estimates. These results highlight the importance of variation at subannual timescales for upscaling to RSG. The results indicated RSG is lower than in recent papers and the current benchmark for land models (98 Pg C year−1), and thus may change the predicted rates of terrestrial carbon turnover and the carbon to climate feedback as global temperatures rise.
Inability To Detect Cross-Reactive Memory T Cells Challenges the Frequency of Heterologous Immunity among Common Viruses

Human memory T cells that cross-react with epitopes from unrelated viruses can potentially modulate immune responses to subsequent infections by a phenomenon termed heterologous immunity. However, it is unclear whether similarities in structure rather than sequence underpin heterologous T cell cross-reactivity. In this study, we aimed to explore the mechanism of heterologous immunity involving immunodominant epitopes derived from common viruses restricted to high-frequency HLA allotypes (HLA-A*02:01, -B*07:02, and -B*08:01). We examined EBV-specific memory T cells for their ability to cross-react with CMV or influenza A virus–derived epitopes. Following T cell immunoassays to determine phenotype and function, complemented with biophysical and structural investigations of peptide/HLA complexes, we did not detect cross-reactivity of EBV-specific memory T cells toward either CMV or influenza A virus epitopes presented by any of the selected HLA allomorphs. Thus, despite the ubiquitous nature of these human viruses and the dominant immune response directed toward the selected epitopes, heterologous virus-specific T cell cross-reactivity was not detected. This suggests that either heterologous immunity is not as common as previously reported, or that it requires a very specific biological context to develop and be clinically relevant.
Visual Weather Temperature Prediction

In this paper, we attempt to employ convolutional recurrent neural networks for weather temperature estimation using only image data. We study ambient temperature estimation based on deep neural networks in two scenarios a) estimating temperature of a single outdoor image, and b) predicting temperature of the last image in an image sequence. In the first scenario, visual features are extracted by a convolutional neural network trained on a large-scale image dataset. We demonstrate that promising performance can be obtained, and analyze how volume of training data influences performance. In the second scenario, we consider the temporal evolution of visual appearance, and construct a recurrent neural network to predict the temperature of the last image in a given image sequence. We obtain better prediction accuracy compared to the state-of-the-art models. Further, we investigate how performance varies when information is extracted from different scene regions, and when images are captured in different daytime hours. Our approach further reinforces the idea of using only visual information for cost efficient weather prediction in the future.
A chemical genetics approach identifies PTP4A3 as a regulator of colon cancer cell adhesion

Dysregulation of the tightly controlled protein phosphorylation networks that govern cellular behavior causes cancer. The membrane‐associated, intracellular protein tyrosine phosphatase PTP4A3 is overexpressed in human colorectal cancer and contributes to cell migration and invasion. To interrogate further the role of PTP4A3 in colorectal cancer cell migration and invasion, we deleted the Ptp4a3 gene from murine colorectal tumor cells. The resulting PTP4A3−/− cells exhibited impaired colony formation, spheroid formation, migration, and adherence compared with the paired PTP4A3fl/fl cells. We replicated these phenotypic changes using the new small‐molecule, allosteric PTP4A3 inhibitor JMS‐053. A related structure, JMS‐038, which lacked phosphatase inhibition, displayed no cellular activity. Reduction in cell viability and colony formation by JMS‐053 occurred in both mouse and human colorectal cell lines and required PTP4A3 expression. Ptp4a3 deletion increased the expression of extracellular matrix (ECM) and adhesion genes, including the tumor suppressor Emilin 1. JMS‐ 053 also increased Emilin 1 gene expression. Moreover, The Cancer Genome Atlas genomic database revealed human colorectal tumors with high Ptp4a3 expression had low Emilin 1 expression. These chemical and biologic reagents reveal a previously unknown communication between the intracellular PTP4A3 phosphatase and the ECM and support efforts to pharmacologically target PTP4A3. —McQueeney, K. E. , Salamoun, J. M. , Ahn, J. G. , Pekic, P., Blanco, I. K. , Struckman, H. L. , Sharlow, E. R. , Wipf, P., Lazo, J. S. A chemical genetics approach identifies PTP4A3 as a regulator of colon cancer cell adhesion. FASEB J. 32, 5661–5673 (2018). www.fasebj. org