Miracle-dz/UniFAR-FTUs huggingface dataset:
TRANSFERENCE FOR THE ERDŐS–KO–RADO THEOREM

For natural numbers $n,r\in \mathbb{N}$ with $n\geqslant r$, the Kneser graph $K(n,r)$ is the graph on the family of $r$-element subsets of $\{1,\ldots ,n\}$ in which two sets are adjacent if and only if they are disjoint. Delete the edges of $K(n,r)$ with some probability, independently of each other: is the independence number of this random graph equal to the independence number of the Kneser graph itself? We shall answer this question affirmatively as long as $r/n$ is bounded away from $1/2$, even when the probability of retaining an edge of the Kneser graph is quite small. This gives us a random analogue of the Erdős–Ko–Rado theorem, since an independent set in the Kneser graph is the same as a uniform intersecting family. To prove our main result, we give some new estimates for the number of disjoint pairs in a family in terms of its distance from an intersecting family; these might be of independent interest.
Assessment of Gastroenteric Viruses Frequency in a Children's Day Care Center in Rio De Janeiro, Brazil: A Fifteen Year Study (1994–2008)

This 15-year study aimed to determine the role of the main viruses responsible for acute infantile gastroenteritis cases in a day care center in the city of Rio de Janeiro, Brazil. From 1994 to 2008, 539 fecal samples were obtained from 23 outbreaks as well as sporadic cases that occurred in this period. The detection of Rotavirus group A (RVA), norovirus (NoV) and astrovirus (AstV) was investigated both by classical and molecular methods of viral detection. RVA was detected by enzymatic immune assay and/or polyacrylamide gel electrophoresis and genotyped by using semi-nested multiplex PCR. NoV and AstV were subsequently tested by real time PCR in all RVA-negative samples and genotyped throughout genome sequencing. Three protocols for molecular characterization of NoV nucleotide sequencing were performed with the partial nucleotide sequencing of genomic regions known as region B (polymerase gen), C and D (capsid gen). Viruses were identified in 47.7% (257/539) of the cases, and the detection rates of RVA, NoV and AstV in16.1% (87/539), 33.4% (151/452), and 6.3% (19/301), respectively. Most gastroenteritis cases were reported in autumn and winter, although NoV presented a broader monthly distribution. Viruses' detection rates were significantly higher among children aged less than 24 months old, although NoV cases were detected in all age groups. RVA genotypes as G1P[8], G9P[8], G2P[4], G3P[8] and G1+G3P[8] and RVA was no longer detected after 2005. NoV characterization revealed genotypes variability circulating in the period as GI.2, GI.3, GI.8 GII.2, GII.3, GII.4, GII.4 variants 2001 and 2006b, GII.6, GII.7, GII.12 and GII.17. AstV genotypes 1, 2, 4 and 5 were also characterized. Those data demonstrate the impact of NoV infection in cases of infantile gastroenteritis, surpassing RVA infection responsible for high morbidity rate in children under five years old.
Mechanical waves conceptual survey: Its modification and conversion to a standard multiple-choice test

In this article we present several modifications of the mechanical waves conceptual survey, the most important test to date that has been designed to evaluate university students’ understanding of four main topics in mechanical waves: propagation, superposition, reflection, and standing waves. The most significant changes are (i) modification of several test questions that had some problems in their original design, (ii) standardization of the number of options for each question to five, (iii) conversion of the two-tier questions to multiple-choice questions, and (iv) modification of some questions to make them independent of others. To obtain a final version of the test, we administered both the original and modified versions several times to students at a large private university in Mexico. These students were completing a course that covers the topics tested by the survey. The final modified version of the test was administered to 234 students. In this study we present the modifications for each question, and discuss the reasons behind them. We also analyze the results obtained by the final modified version and offer a comparison between the original and modified versions. In the Supplemental Material we present the final modified version of the test. It can be used by teachers and researchers to assess students’ understanding of, and learning about, mechanical waves.
The effect on quality of life of vitamin D administration for advanced cancer treatment (VIDAFACT study): protocol of a randomised controlled trial

Introduction Vitamin D is related to resistance to chronic diseases, physiological parameters and functional measures. All of these relationships underscore the potential benefits of cholecalciferol or D3 (nutritional vitamin D) in cancer. This is the first study designed to obtain conclusive evidence on the effect of cholecalciferol in advanced patients with cancer. The main goal is to assess its effects on the patient's perceived quality of life. Cholecalciferol's impact on fatigue and physical performance, as well as its cost utility, will also be assessed. Methods and analysis A randomised triple-blind phase II/III placebo-controlled multicentre trial has been designed. Patients satisfying the inclusion and exclusion criteria will be randomly assigned to receive cholecalciferol or placebo. Eligible patients will be adults with a locally advanced or metastatic or inoperable solid cancer in palliative care, who have given signed informed consent and have matched inclusion and exclusion criteria. The randomisation will be based on a computer-generated procedure and centralised by the pharmacy service of the coordinating centre. The assigned treatment will be administered by the hospital's pharmacy to conceal group allocation for patients and healthcare providers. Cholecalciferol (4000 IU/day) or placebo, starting at day 15 and continuing up to day 42, will be added to palliative care treatment. Outpatient visits will be scheduled every 14 days. Ethics and dissemination Ethical approval was received from the Medical Ethical Commitee of the HUAV (CEIC-1169). Participants and their families will receive the research findings which will also be disseminated on local and national media, presented at national and international meetings of the specialty, and published in peer-reviewed scientific journals. Trial registration number EudraCT: 2013-003478-29.
Collusion Attack-Resilient Hierarchical Encryption of JPEG 2000 Codestreams with Scalable Access Control

This paper proposes a collusion attack-resilient method of encryption for access control of JPEG 2000 codestreams with hierarchical scalabilities. The proposed method generates one encryption key from one single key by multi-dimensional scanning to serve encryption keeping the scalability of codestrems. To avoid collusion attacks in which multiple users generate an illegal key from their own keys to overcome the access control, sufficient conditions are considered in this method. Moreover, a skip encryption is introduced to decrease the computational complexity and key management-and-de-livery cost of encryption. Simulation results show the effectiveness of the proposed method.
HDAC3 Is a Critical Negative Regulator of Long-Term Memory Formation

Gene expression is dynamically regulated by chromatin modifications on histone tails, such as acetylation. In general, histone acetylation promotes transcription, whereas histone deacetylation negatively regulates transcription. The interplay between histone acetyltranserases and histone deacetylases (HDACs) is pivotal for the regulation of gene expression required for long-term memory processes. Currently, very little is known about the role of individual HDACs in learning and memory. We examined the role of HDAC3 in long-term memory using a combined genetic and pharmacologic approach. We used HDAC3–FLOX genetically modified mice in combination with adeno-associated virus-expressing Cre recombinase to generate focal homozygous deletions of Hdac3 in area CA1 of the dorsal hippocampus. To complement this approach, we also used a selective inhibitor of HDAC3, RGFP136 [N-(6-(2-amino-4-fluorophenylamino)-6-oxohexyl)-4-methylbenzamide]. Immunohistochemistry showed that focal deletion or intrahippocampal delivery of RGFP136 resulted in increased histone acetylation. Both the focal deletion of HDAC3 as well as HDAC3 inhibition via RGFP136 significantly enhanced long-term memory in a persistent manner. Next we examined expression of genes implicated in long-term memory from dorsal hippocampal punches using quantitative reverse transcription-PCR. Expression of nuclear receptor subfamily 4 group A, member 2 (Nr4a2) and c-fos was significantly increased in the hippocampus of HDAC3–FLOX mice compared with wild-type controls. Memory enhancements observed in HDAC3–FLOX mice were abolished by intrahippocampal delivery of Nr4a2 small interfering RNA, suggesting a mechanism by which HDAC3 negatively regulates memory formation. Together, these findings demonstrate a critical role for HDAC3 in the molecular mechanisms underlying long-term memory formation.
Oral anticancer agent medication adherence by outpatients

In the present study, medication adherence and factors affecting adherence were examined in patients taking oral anticancer agents. In June 2013, 172 outpatients who had been prescribed oral anticancer agents by Ogaki Municipal Hospital (Ogaki, Gifu, Japan) completed a questionnaire survey, with answers rated on a five-point Likert scale. The factors that affect medication adherence were evaluated using a customer satisfaction (CS) analysis. For patients with good and insufficient adherence to medication, the median ages were 66 years (range, 21–85 years) and 73 years (range, 30–90 years), respectively (P=0.0004), while the median dosing time was 131 days (range, 3–3,585 days) and 219 days (24–3,465 days), respectively (P=0.0447). In 36.0% (62 out of 172) of the cases, there was insufficient medication adherence; 64.5% of those cases (40 out of 62) showed good medication compliance (4–5 point rating score). However, these patients did not fully understand the effects or side-effects of the drugs, giving a score of three points or less. The percentage of patients with good medication compliance was 87.2% (150 out of 172). Through the CS analysis, three items, the interest in the drug, the desire to consult about the drug and the condition of the patient, were extracted as items for improvement. Overall, the medication compliance of the patients taking the oral anticancer agents was good, but the medication adherence was insufficient. To improve medication adherence, a better understanding of the effectiveness and necessity of drugs and their side-effects is required. In addition, the interest of patients in their medication should be encouraged and intervention should be tailored to the condition of the patient. These steps should lead to improved medication adherence.
Cardiopulmonary and anesthetic effects of the combination of butorphanol, midazolam and alfaxalone in Beagle dogs.

OBJECTIVE To evaluate the physiological variables, arterial blood gas values, induction of anesthesia quality, and recovery quality using the combination of butorphanol, midazolam and alfaxalone in dogs. ANIMALS Ten healthy adult Beagle dogs weighing 8.3 ± 3.1 kg. METHODS Rectal temperature (T), pulse rate (PR), respiratory rate (f(R)), mean arterial pressure (MAP), and arterial blood gases were measured and recorded prior to intravenous (IV) administration of butorphanol, prior to administration of both midazolam and alfaxalone IV 10 minutes later, then every 5 minutes for 20 minutes. M-mode echocardiographic left ventricular (LV) indices were measured before and 5 minutes after administration of alfaxalone. Qualitative scores for induction of anesthesia and recovery were allocated, duration of anesthesia and recovery were calculated, and adverse events were recorded. RESULTS Scores for induction and recovery quality were excellent. No significant adverse events were observed. Mean ± SD time from induction to extubation and to standing (full recovery) was 29 ± 6 and 36 ± 8 minutes, respectively. There were statistically significant changes in PR, f(R) and MAP after drug administration. Transient hypercarbia developed after alfaxalone injection. The echocardiographic LV indices were reduced after alfaxalone injection, although those changes were not statistically significant. CONCLUSIONS AND CLINICAL RELEVANCE The combination of butorphanol, midazolam and alfaxalone provided excellent quality of induction of anesthesia and exerted minimal cardiopulmonary effects in healthy dogs.
All that Glitters: The Effect of Attention and News on the Buying Behavior of Individual and Institutional Investors

We test and confirm the hypothesis that individual investors are net buyers of attention-grabbing stocks, e.g., stocks in the news, stocks experiencing high abnormal trading volume, and stocks with extreme one-day returns. Attention-driven buying results from the difficulty that investors have searching the thousands of stocks they can potentially buy. Individual investors do not face the same search problem when selling because they tend to sell only stocks they already own. We hypothesize that many investors consider purchasing only stocks that have first caught their attention. Thus, preferences determine choices after attention has determined the choice set. , Oxford University Press.
Inhibitory control in children with traumatic brain injury (TBI) and children with attention deficit/hyperactivity disorder (ADHD).

The behavioural and cognitive sequelae of traumatic brain injury (TBI) have features in common with attention deficit/hyperactivity disorder (ADHD), best characterized by deficits in response inhibition.The performance was, therefore, examined of 27 children with TBI, 31 children with developmental ADHD, and 26 matched controls aged 8-12, on two inhibition tasks: the Stop-Signal Task and a Delayed-Response-Task. Children with TBI and children with ADHD showed a pervasive deficit in their inhibitory control processes with respect to inhibition of both pre-potent and on-going responses. In addition, children with TBI were found to suffer from a general slowing of their information processing, which was not correlated with the inhibition deficit. TBI children with and without a secondary ADHD differed only tendentially in their Mean Go-Reaction time in the stop-task. However, subdividing TBI children according to actigraph data into hypo-, hyper- and normokinetic subgroups revealed that the hyperactive TBI children had inhibitory deficit patterns that were similar to children with developmental ADHD. It is concluded that slowing of information processing speed seems to be a general consequence of TBI in childhood, whereas slowing of the stop-processes or inhibitory deficits, specifically, are associated with post-injury hypo- or hyperactivity.
The brief resilience scale: Assessing the ability to bounce back

Background: While resilience has been defined as resistance to illness, adaptation, and thriving, the ability to bounce back or recover from stress is closest to its original meaning. Previous resilience measures assess resources that may promote resilience rather than recovery, resistance, adaptation, or thriving. Purpose: To test a new brief resilience scale. Method: The brief resilience scale (BRS) was created to assess the ability to bounce back or recover from stress. Its psychometric characteristics were examined in four samples, including two student samples and samples with cardiac and chronic pain patients. Results: The BRS was reliable and measured as a unitary construct. It was predictably related to personal characteristics, social relations, coping, and health in all samples. It was negatively related to anxiety, depression, negative affect, and physical symptoms when other resilience measures and optimism, social support, and Type D personality (high negative affect and high social inhibition) were controlled. There were large differences in BRS scores between cardiac patients with and without Type D and women with and without fibromyalgia. Conclusion: The BRS is a reliable means of assessing resilience as the ability to bounce back or recover from stress and may provide unique and important information about people coping with health-related stressors.
Hereditary Pancreatitis-associated Mutation Asn21 → Ile Stabilizes Rat Trypsinogen in Vitro *

Mutations Arg117 → His and Asn21 → Ile in human trypsinogen-I have been recently associated with hereditary pancreatitis (HP). The Arg117→ His substitution is believed to cause pancreatitis by stabilizing trypsin against autolytic degradation, while the mechanism of action of Asn21 → Ile has been unknown. In an effort to understand the effect(s) of this mutation, Thr21 in the highly homologous rat trypsinogen-II was replaced with Asn or Ile, and the recombinant zymogens and their active trypsin forms were studied. Kinetic parameters of all three trypsins were comparable, and the active enzymes suffered autolysis at similar rates, indicating that neither catalytic properties nor proteolytic stability of trypsin are influenced by mutations at position 21. When incubated at pH 8.0, 37 °C, pure zymogens underwent autoactivation with concomitant trypsinolytic degradation in a Ca2+-dependent fashion. Thus, in the presence of 5 mm Ca2+, autoactivation and digestion of the zymogens after Arg117and Lys188 were observed, while in the presence of 1 mm EDTA autoactivation and cleavage at Lys188were reduced, and zymogenolysis at the Arg117 site was enhanced. Overall rates of zymogen degradation in [Asn21]- and [Ile21]trypsinogens were higher in Ca2+ than in EDTA, while [Thr21]trypsinogen demonstrated inverse characteristics. Remarkably, both in the presence and absence of Ca2+, [Ile21]trypsinogen exhibited significantly higher stability against autoactivation and proteolysis than zymogens with Asn21 or Thr21. The observations suggest that autocatalytic trypsinogen degradation may be an important defense mechanism against excessive trypsin generation in the pancreas, and trypsinogen stabilization by the Asn21 → Ile mutation plays a role in the pathogenesis of HP.
Comparison of two partial discharge classification methods

Two signal classification methods have been examined to discover their suitability for the task of partial discharge (PD) identification. An experiment has been designed to artificially mimic signals produced by a range of PD sources that are known to occur within high voltage (HV) items of plant. The bushing tap point of a large Auto-transformer has been highlighted as a possible point on which to attach PD sensing equipment and is utilized in this experiment. Artificial PD signals are injected into the HV electrode of the bushing itself and a high frequency current transformer (HFCT) is used to monitor the current between the tap-point and earth. The experimentally produced data was analyzed using two different signal processing algorithms and their classification performance compared. The signals produced by four different artificial PD sources (surface discharge in air, corona discharge in air, floating discharge in oil and internal discharge in oil) have been processed, then classified using two machine learning techniques, namely the support vector machine (SVM) and probabilistic neural network (PNN). The feature extraction algorithms involve performing wavelet packet analysis on the PD signals recorded over a single power cycle. The dimensionality of the data has been reduced by finding the first four moments of the probability density function (Mean, Standard deviation, Skew and Kurtosis) of the wavelet packet coefficients to produce a suitable feature vector. Initial results indicate that very high identification rates are possible with the SVM able to classify PD signals with a slightly higher accuracy than a PNN.
Medicolegal Aspects of Decomposition and Factors Affecting Its Occurrence in Qena and Luxor Governorates

Decomposition problems have existed since the first autopsy and persist to this day. Decomposition depends on intrinsic and extrinsic factors; temperature is the most important one.Objective: To study the medicolegal aspects of decomposition and factors affecting its occurrence in Qena and Luxor governorates. Subjects and methods: A retrospective (from 1/1/2011 to 31/12/2015), in which the decomposed cases were collected and reviewed from autopsy files, and prospective (from 1/10/2016 to 31/3/2017) study conducted in Qena Medicolegal Department (Qena and Luxor governorates), Ministry of Justice.Results: The decomposed cases in the retrospective periods ranged from (13.5 %) in 2011 to (15.7 %) in 2015 and represented (14 %) in the prospective period. Males outnumbered females, where the ratio in the retrospective periods ranged from (8.25:1) in 2013 to (2.23:1) in 2014 and represented (5:1) in the prospective period. Most cases were in the 3rd, 4th decades and full terms. Incised injuries, pathological conditions, starvation and firearm injuries were the most common causes of death, while the highest percentages of undetermined deaths were (50 %) in the retrospective periods and (33.33 %) in the prospective period. The most common sites of death were homes in 2015 (60 %) and water in the prospective period (66.67 %). The fewer layers of clothes, the more accelerated decomposition. The highest percentages of cases were found in June, 2015 (31.4 %), and in March and October of the prospective period (27.8 %).
Fast gaze typing with an adjustable dwell time

Previous research shows that text entry by gaze using dwell time is slow, about 5-10 words per minute (wpm). These results are based on experiments with novices using a constant dwell time, typically between 450 and 1000 ms. We conducted a longitudinal study to find out how fast novices learn to type by gaze using an adjustable dwell time. Our results show that the text entry rate increased from 6.9 wpm in the first session to 19.9 wpm in the tenth session. Correspondingly, the dwell time decreased from an average of 876 ms to 282 ms, and the error rates decreased from 1.28% to . 36%. The achieved typing speed of nearly 20 wpm is comparable with the result of 17.3 wpm achieved in an earlier, similar study with Dasher.
Complexity and information: Measuring emergence, self-organization, and homeostasis at multiple scales

Concepts used in the scientific study of complex systems have become so widespread that their use and abuse has led to ambiguity and confusion in their meaning. In this article, we use information theory to provide abstract and concise measures of complexity, emergence, self-organization, and homeostasis. The purpose is to clarify the meaning of these concepts with the aid of the proposed formal measures. In a simplified version of the measures (focusing on the information produced by a system), emergence becomes the opposite of self-organization, while complexity represents their balance. Homeostasis can be seen as a measure of the stability of the system. We use computational experiments on random Boolean networks and elementary cellular automata to illustrate our measures at multiple scales. © 2012 Wiley Periodicals, Inc. Complexity, 2012 © 2012 Wiley Periodicals, Inc.