Miracle-dz/UniFAR-FTUs huggingface dataset:
Unconscious Relational Inference Recruits the Hippocampus

Relational inference denotes the capacity to encode, flexibly retrieve, and integrate multiple memories to combine past experiences to update knowledge and improve decision-making in new situations. Although relational inference is thought to depend on the hippocampus and consciousness, we now show in young, healthy men that it may occur outside consciousness but still recruits the hippocampus. In temporally distinct and unique subliminal episodes, we presented word pairs that either overlapped (“winter–red”, “red–computer”) or not. Effects of unconscious relational inference emerged in reaction times recorded during unconscious encoding and in the outcome of decisions made 1 min later at test, when participants judged the semantic relatedness of two supraliminal words. These words were either episodically related through a common word (“winter–computer” related through “red”) or unrelated. Hippocampal activity increased during the unconscious encoding of overlapping versus nonoverlapping word pairs and during the unconscious retrieval of episodically related versus unrelated words. Furthermore, hippocampal activity during unconscious encoding predicted the outcome of decisions made at test. Hence, unconscious inference may influence decision-making in new situations.
Analytic solutions of hydrodynamics equations

Many similarity solutions have been found for the equations of one‐dimensional (1‐D) hydrodynamics. These special combinations of variables allow the partial differential equations to be reduced to ordinary differential equations, which must then be solved to determine the physical solutions. Usually, these reduced ordinary differential equations are solved numerically. In some cases it is possible to solve these reduced equations analytically to obtain explicit solutions. In this work a collection of analytic solutions of the 1‐D hydrodynamics equations is presented. These can be used for a variety of purposes, including (i) numerical benchmark problems, (ii) as a basis for analytic models, and (iii) to provide insight into more complicated solutions.
The Enigma of Tripeptidyl-Peptidase II: Dual Roles in Housekeeping and Stress

The tripeptidyl-peptidase II complex consists of repeated 138 kDa subunits, assembled into two twisted strands that form a high molecular weight complex (>5 MDa). TPPII, like many other cytosolic peptidases, plays a role in the ubiquitin-proteasome pathway downstream of the proteasome as well as in the production and destruction of MHC class I antigens and degradation of neuropeptides. Tripeptidyl-peptidase II activity is increased in cells with an increased demand for protein degradation, but whether degradation of cytosolic peptides is the only cell biological role for TPPII has remained unclear. Recent data indicated that TPPII translocates into the nucleus to control DNA damage responses in malignant cells, supporting that cytosolic “housekeeping peptidases” may have additional roles in cell biology, besides their contribution to protein turnover. Overall, TPPII has an emerging importance in several cancer-related fields, such as metabolism, cell death control, and control of genome integrity; roles that are not understood in detail. The present paper reviews the cell biology of TPPII and discusses distinct roles for TPPII in the nucleus and cytosol.
Neurorehabilitation and Neural Repair Inter-individual Variability in the Capacity for Motor Recovery after Ischemic Stroke Neurorehabilitation and Neural Repair Additional Services and Information for Inter-individual Variability in the Capacity for Motor Recovery after Ischemic Stroke

Background. Motor recovery after stroke is predicted only moderately by clinical variables, implying that there is still a substantial amount of unexplained, biologically meaningful variability in recovery. Regression diagnostics can indicate whether this is associated simply with Gaussian error or instead with multiple subpopulations that vary in their relationships to the clinical variables. Objective. To perform regression diagnos-tics on a linear model for recovery versus clinical predictors. Methods. Forty-one patients with ischemic stroke were studied. Impairment was assessed using the upper extremity Fugl-Meyer Motor Score. Motor recovery was defined as the change in the upper extremity Fugl-Meyer Motor Score from 24 to 72 hours after stroke to 3 or 6 months later. The clinical predictors in the model were age, gender, infarct location (subcortical vs corti-cal), diffusion weighted imaging infarct volume, time to reassessment, and acute upper extremity Fugl-Meyer Motor Score. Regression diagnostics included a Kolmogorov-Smirnov test for Gaussian errors and a test for outliers using Studentized deleted residuals. Results. In the random sample, clinical variables explained only 47% of the variance in recovery. Among the patients with the most severe initial impairment, there was a set of regression outliers who recovered very poorly. With the outliers removed, explained variance in recovery increased to 89%, and recovery was well approximated by a proportional relationship with initial impairment (recovery ≅ 0.70 × initial impairment). Conclusions. Clinical variables only moderately predict motor recovery. Regression diagnostics demonstrated the existence of a subpopulation of outliers with severe initial impairment who show little recovery. When these outliers were removed, clinical variables were good predictors of recovery among the remaining patients, showing a tight proportional relationship to initial impairment.
The Monogenean Parasite Fauna of Cichlids: A Potential Tool for Host Biogeography

We discuss geographical distribution and phylogeny of Dactylogyridea (Monogenea) parasitizing Cichlidae to elucidate their hosts' history. Although mesoparasitic Monogenea (Enterogyrus spp.) show typical vicariant distribution, ectoparasitic representatives from different continents are not considered sister taxa, hence their distribution cannot result from vicariance alone. Because of the close host-parasite relationship, this might indicate that present-day cichlid distribution may also reflect dispersal through coastal or brackish waters. Loss of ectoparasites during transoceanic migration, followed by lateral transfer from other fish families might explain extant host-parasite associations. Because of its mesoparasitic nature, hence not subject to salinity variations of the host's environment, Enterogyrus could have survived marine migrations, intolerable for ectoparasites. Host-switches and salinity transitions may be invoked to explain the pattern revealed by a preliminary morphological phylogeny of monogenean genera from Cichlidae and other selected Monogenea genera, rendering the parasite distribution explicable under both vicariance and dispersal. Testable hypotheses are put forward in this parasitological approach to cichlid biogeography. Along with more comprehensive in-depth morphological phylogeny, comparison with molecular data, clarifying dactylogyridean evolution on different continents and from various fish families, and providing temporal information on host-parasite history, are needed to discriminate between the possible scenarios.
Preventing Keystroke Based Identification in Open Data Sets

Large-scale courses such as Massive Online Open Courses (MOOCs) can be a great data source for researchers. Ideally, the data gathered on such courses should be openly available to all researchers. Studies could be easily replicated and novel studies on existing data could be conducted. However, very fine-grained data such as source code snapshots can contain hidden identifiers. For example, distinct typing patterns that identify individuals can be extracted from such data. Hence, simply removing explicit identifiers such as names and student numbers is not sufficient to protect the privacy of the users who have supplied the data. At the same time, removing all keystroke information would decrease the value of the shared data significantly. In this work, we study how keystroke data from a programming context could be modified to prevent keystroke latency based identification whilst still retaining information that can be used to e.g. infer programming experience. We investigate the degree of anonymization required to render identification of students based on their typing patterns unreliable. Then, we study whether the modified keystroke data can still be used to infer the programming experience of the students as a case study of whether the anonymized typing patterns have retained at least some informative value. We show that it is possible to modify data so that keystroke latency based identification is no longer accurate, but the programming experience of the students can still be inferred, i.e. the data still has value to researchers. In a broader context, our results indicate that information and anonymity are not necessarily mutually exclusive.
How the operated larynx ages

SUMMARY After open partial laryngectomy (HOPL), many patients experience deterioration of laryngeal function over time. The aim of this study was to evaluate laryngeal functional outcome at least 10 years after surgery in a cohort of 80 elderly patients. The incidence of aspiration pneumonia (AP) and objective/subjective laryngeal functional assessments were carried out. Eight patients experienced AP including four with repeated episodes. A significant association was observed between AP and severity of dysphagia (p < 0.001). Dysphagia was more pronounced than in a normal population of similar age, but less than would be expected. There was a significant association between the type of intervention and grade of dysphagia/dysphonia; a difference in voice handicap was found, depending on the extent of glottic resection. After HOPL, laryngeal function was impaired, but this did not significantly affect the quality of life. AP is more frequent in the initial post-operative period, and decreases in subsequent years.
Vocation in Theology and Psychology: Conflicting Approaches?

ABSTRACT Recent contributions in the fields of psychology, sociology, and theology reveal opposing attitudes about the subject of calling or vocation with regard to one's work. Whereas psychologists have rediscovered the concept, theologians increasingly show reluctance to accept a vocational view of work. In offering an alternative perspective, this article argues that an approach to calling from biblical theology is capable of inspiring Christian workers in a psychologically meaningful way, while avoiding the inadequacies of the understanding that “work is vocation” that was developed during the Protestant Reformation. In a biblical-theological approach, work is not equated with calling. Rather, it is perceived as practicing the love command and hope for a restoration of God's intentions for creation, emanating from the call into fellowship with Christ and a vision for the kingdom of God.
TRESOR Runs Encryption Securely Outside RAM

Current disk encryption techniques store necessary keys in RAM and are therefore susceptible to attacks that target volatile memory, such as Firewire and cold boot attacks. We present TRESOR, a Linux kernel patch that implements the AES encryption algorithm and its key management solely on the microprocessor. Instead of using RAM, TRESOR ensures that all encryption states as well as the secret key and any part of it are only stored in processor registers throughout the operational time of the system, thereby substantially increasing its security. Our solution takes advantage of Intel's new AES-NI instruction set and exploits the x86 debug registers in a non-standard way, namely as cryptographic key storage. TRESOR is compatible with all modern Linux distributions, and its performance is on a par with that of standard AES implementations.
Perceptual abilities in case of low vision, using a virtual reality environment

Losing our relationship with our environmental conditions may reduce our cognitive abilities to understand them, and so to interact within. Through the SENSIVISE virtual space, we analyzed the perceptual abilities of 27 visually impaired people and 6 controls to perceive and interact while achieving requested tasks based on global or objects perception and recognition. We also tested the contribution of SENSIVISE's adaptations in improving performance and perception. Our results show a large variability of the performance among participants with low vision, according to visual deficiency, task features, and environmental conditions.
The Effect of Haptic, Visual and Auditory Feedback on an Insertion Task on a 2-Screen Workbench

This paper reports on an experiment built to investigate the effect of haptic, visual and auditory additional information on the performances of a user operating an insertion task in virtual reality. Sensory information is added, during the insertion, when a collision occurs between the manipulated virtual object and some other part of the virtual scene. The experimental apparatus uses a 2-screen workbench and a new wearable haptic interface: the Wearable Haptic Handle (W2H) which provides tactile stimulation inside the user’s hand. It seems that none of the additional information has a positive impact on the completion time of the task, when compared to the control condition (the visual feedback of the virtual scene alone). However, the movement of the subject when colliding is more limited in the presence of an additional information. The subject apparently pays more attention to the collision but, in return, achieve the task more slowly. Furthermore, the directional information of the W2H seems to be difficult to understand and to use. The perceptive characteristics of the human hand are directly questioned by this surprising result. At last, the different types of haptic feedback are mostly appreciated by the subjects. They are perceived as useful, pleasant and able to improve the realism of the simulation.
Jns Journal of Nutritional Science

A gene expression programme induced by bovine colostrum whey promotes growth and wound-healing processes in intestinal epithelial cells Abstract Bovine colostrum is well known for its beneficial properties on health and development. It contains a wide variety of bioactive ingredients that are known to promote a number of cellular processes. Therefore the use of colostrum whey as a feed additive to promote intestinal health has been proposed, yet little is known about mechanisms implicated in its beneficial properties on intestinal epithelial cells. In the present paper, casein were removed from bovine col-ostrum and the remaining liquid, rich in bioactive compounds, was evaluated for its capacity to modulate cellular processes in porcine intestinal epithelial cell line IPEC-J2 and human colon adenocarcinoma cell line Caco-2/15. First, we verified the effect of colostrum whey and cheese whey on processes involved in intestinal wound healing, including cell proliferation, attachment, morphology and migration. Our results showed that colostrum whey promoted proliferation and migration, and decreased specifically the attachment of Caco-2/15 cells on the culture dish. On the other hand, cheese whey induced proliferation and morphological changes in IPEC-J2 cells, but failed to induce migration. The gene expression profile of IPEC-J2 cells following colostrum whey treatment was evaluated by microarray analysis. Results revealed that the expression of a significant number of genes involved in cell migration , adhesion and proliferation was indeed affected in colostrum whey-treated cells. In conclusion, colostrum specific bioactive content could be beneficial for intestinal epithelial cell homoeostasis by controlling biological processes implicated in wound healing through a precise gene expression programme. Intestinal epithelium integrity is crucial to maintain barrier function of the gastrointestinal tract. For numbers of digestive disorders, including inflammatory bowel diseases, the disruption of barrier integrity is a key event determining the outcomes of the disease (1,2). To restore tissue homoeostasis following injury, a rapid activation of the wound-healing process is required. First, wound healing is initiated by epithelial restitution, during which cells surrounding the wound lose their polarity, undergo complex alterations of their adhesion properties, change their morphology and migrate toward the denuded area to cover the defect (3–5). This is followed by cell proliferation, which is triggered to fill the wound with new enterocytes. Eventually, cell differentiation occurs to re-establish tissue architecture and function. There is a wide variety of factors that can affect intestinal restitution and proliferation, including growth factors, such as transforming growth factor-beta (TGF-β) and …
Generation of broad XUV continuous high harmonic spectra and isolated attosecond pulses with intense mid-infrared lasers

We present experimental results showing the appearance of a near-continuum in the high-order harmonic generation spectra of atomic and molecular species as the driving laser intensity of a mid-infrared pulse increases. Detailed macroscopic simulations reveal that these near-continuum spectra are capable of producing isolated attosecond pulses (IAPs) in the far field if a proper spatial filter is applied. Further, our simulations show that the near-continuum spectra and the IAPs are a product of the strong temporal and spatial reshaping (blue shift and defocusing) of the driving field. This offers a possibility of producing IAPs with a broad range of photon energy, including plateau harmonics, by mid-IR laser pulses even without carrier-envelope phase stabilization.
The impact of epididymal and accessory sex gland function on sperm motility.

BACKGROUND Little is known about the regulation of sperm motility, which is an important predictor of male fertility. However, both testicular and post-testicular factors may be involved, although the impact of the latter has been relatively poorly investigated. METHODS In semen samples from 301 young men from the general Swedish population (mean +/- SD age 18.2 +/- 0.4 years), we assessed sperm motility by use of a manual method as well as computer-assisted sperm analysis (CASA) and correlated these values to seminal levels of neutral alpha-glucosidase (NAG), prostate-specific antigen (PSA), zinc and fructose. RESULTS There were significant positive correlations between seminal levels of NAG, and PSA and CASA percentage motile sperm (r = 0.158, P = 0.009; r = 0.155, P = 0.01 respectively), and significant negative correlations with CASA percentage immotile sperm (r = -0.206, P = 0.001; r = -0.157, P = 0.009 respectively). In a multiple regression analysis it was found that, apart from sperm concentration, the level of PSA was the most significant and independent parameter in predicting percentage motile sperm (beta = 0.220, P = 0.037). CONCLUSION Our study demonstrated the regulatory effect of post-testicular glands on the motility of sperm. This is to our knowledge the first study showing a direct correlation between the seminal PSA levels and sperm motility in a group of men representing the general population. In future investigations and searches for specific treatment modalities in male infertility, more attention should be paid to the epididymis and accessory sex gland function.
Gender Differences in Reading Impairment and in the Identification of Impaired Readers

Reading impairment is more common in males, but the magnitude and origin of this gender difference are debated. In a large-scale study of reading impairment among 491,103 beginning second-graders, gender differences increased with greater severity of reading impairment, peaking at a ratio of 2.4:1 for a broad measure of fluency and a ratio of 1.6:1 for a narrow measure of decoding. Results from three tests indicate that gender differences in reading impairment are attributable primarily to male vulnerability rather than ascertainment bias. Correspondence between identification as an impaired reader by our study criteria and school identification as learning disabled was poor overall and worse for girls: Only 1 out of 4 boys and 1 out of 7 girls identified as reading impaired in our study was school identified as learning disabled.
Market Contagion: Evidence from the Panics of 1854 and 1857

To test a model of contagion--where individuals hear some bad news and communicate it to their acquaintances, who then pass it on, leading to a market panic--requires a knowledge of the information networks of participants, something hitherto unavailable. For two panics in the 1850s this paper examines the behavior of Irish depositors in a New York bank. As recent immigrants, their social network was determined largely by their place of origin in Ireland, and where they lived in New York. During both panics this social network turns out to be the prime determinant of behavior.
Multiplicity, invariants and tensor product decompositions of tame representations of U(∞)

The structure of r-fold tensor products of irreducible tame representations of U(∞)=lim lim → U(n) are described, versions of contragredient representations and invariants are realized, and methods of calculating multiplicities, Clebsch–Gordan, and Racah coefficients are given using invariant theory on Bargmann–Segal–Fock spaces.
Functional Characterization of Schizophrenia-Associated Variation in CACNA1C

Calcium channel subunits, including CACNA1C, have been associated with multiple psychiatric disorders. Specifically, genome wide association studies (GWAS) have repeatedly identified the single nucleotide polymorphism (SNP) rs1006737 in intron 3 of CACNA1C to be strongly associated with schizophrenia and bipolar disorder. Here, we show that rs1006737 marks a quantitative trait locus for CACNA1C transcript levels. We test 16 SNPs in high linkage disequilibrium with rs1007637 and find one, rs4765905, consistently showing allele-dependent regulatory function in reporter assays. We find allele-specific protein binding for 13 SNPs including rs4765905. Using protein microarrays, we identify several proteins binding ≥3 SNPs, but not control sequences, suggesting possible functional interactions and combinatorial haplotype effects. Finally, using circular chromatin conformation capture, we show interaction of the disease-associated region including the 16 SNPs with the CACNA1C promoter and other potential regulatory regions. Our results elucidate the pathogenic relevance of one of the best-supported risk loci for schizophrenia and bipolar disorder.