Miracle-dz/UniFAR-FTUs huggingface dataset:
Do Sources of Meaning Differentially Predict Search for Meaning, Presence of Meaning, and Wellbeing

Meaning in life is vital for human wellbeing. Research has examined important sources of meaning: however, it has not yet investigated whether certain sources of meaning might be more predictive of overall meaning and wellbeing. A community sample of 247 individuals (30 – 69 years) rated the degree of meaningfulness they experienced in certain domains and completed 11 wellbeing measures. Presence of meaning was positively predicted by family and interpersonal relations, and negatively by leisure activities; search for meaning was positively predicted by personal growth and religiosity/spirituality. Meaning from family and health aided in the process of searching for meaning leading to presence of meaning; similarly, meaning from family, interpersonal relationships, health, religiosity/spirituality and life in general buffered against impoverished wellbeing when searching for meaning. Presence and wellbeing were both higher if the domains of work, family, interpersonal relations, community/society issues, and life in general were highly endorsed. Lastly, highly endorsing a larger number of sources buffered against negative wellbeing outcomes when searching for meaning. Overall, we found that meaning from important domains such as family and interpersonal relationships, and strongly endorsing a wide variety of sources, protected against negative wellbeing outcomes when searching for meaning.
Testing Restrictions in a Flexible Dynamic Demand System: An Application to Consumers' Expenditure in Canada

Traditionally, restrictions on systems of demand equations have been tested using static models, whilst being estimated with time series data. This paper develops a vector time series model of expenditure shares in the context of a singular dynamic demand system. The model allows for non-symmetric and non-homogeneous short run behaviour. The homogeneity and symmetry restrictions are only examined in the long run structure. Results based on Canadian time series data are presented and reject the current practise of static modelling while restrictions suggested by economic theory are not rejected when imposed on the long run structure.
Private Strategies in Finitely Repeated Games with Imperfect Public Monitoring

Abstract We present three examples of finitely repeated games with public monitoring that have sequential equilibria in private strategies, i.e., strategies that depend on own past actions as well as public signals. Such private sequential equilibria can have features quite unlike those of the more familiar perfect public equilibria: (i) making a public signal less informative can create Pareto superior equilibrium outcomes; (ii) the equilibrium final-period action profile need not be a stage game equilibrium; and (iii) even if the stage game has a unique correlated (and hence Nash) equilibrium, the first-period action profile need not be a stage game equilibrium.
Hepatoblastoma state of the art: pathology, genetics, risk stratification, and chemotherapy

Purpose of review As a rare pediatric tumor, hepatoblastoma presents challenges to the individual practitioner as no center will see more than a handful of cases each year. Recent findings The Children's Hepatic tumor International Collaborative (CHIC) effort has fostered international cooperation in this rare children's tumor, leading to the establishment of a large international collaborative dataset, the CHIC database, which has been interrogated to refine risk stratification and inform treatment options. Apace with this effort has been the international collaboration of pediatric pathologists working together to establish a new international histopathologic consensus classification for pediatric liver tumors as a whole, with particular focus on the histological subtypes of hepatoblastoma. Summary International collaborative efforts in hepatoblastoma have led to a new international histopathologic consensus classification, refinements in risk stratification, advances in chemotherapy, and a better understanding of surgical resection options forming the foundation for the development of an upcoming international therapeutic trial.
Galaxy And Mass Assembly (GAMA): the halo mass of galaxy groups from maximum-likelihood weak lensing

We present a maximum-likelihood weak-lensing analysis of the mass distribution in optically selected spectroscopic Galaxy Groups (G3Cv5) in the Galaxy And Mass Assembly (GAMA) survey, using background Sloan Digital Sky Survey (SDSS) photometric galaxies. The scaling of halo mass, Mh, with various group observables is investigated. Our main results are as follows. (1) The measured relations of halo mass with group luminosity, virial volume and central galaxy stellar mass, M*, agree very well with predictions from mock group catalogues constructed from a GALFORM semi-analytical galaxy formation model implemented in the Millennium ΛCDM N-body simulation. (2) The measured relations of halo mass with velocity dispersion and projected half-abundance radius show weak tension with mock predictions, hinting at problems in the mock galaxy dynamics and their small-scale distribution. (3) The median Mh|M* measured from weak lensing depends more sensitively on the lognormal dispersion in M* at fixed Mh than it does on the median M*|Mh. Our measurements suggest an intrinsic dispersion of σlog(M*)∼ 0.15. (4) Comparing our mass estimates with those in the catalogue, we find that the G3Cv5 mass can give biased results when used to select subsets of the group sample. Of the various new halo-mass estimators that we calibrate using our weak-lensing measurements, group luminosity is the best single-proxy estimator of group mass.
A Modified JPDA

This paper presents a coupled, joint probabilistic data association (JPDA) algorithm for multi-target tracking using a modified version of the standard measurement-to-track assignment model. The mutually exclusive nature of standard JPDA association events precludes any measurement being associated with more than one target in a given event. This constraint is relaxed here to allow a measurement to be assigned to multiple targets. All other JPDA assumptions are retained (i.e., no measurement can be simultaneously associated with target and clutter, and each track can claim at most one measurement). The computational requirements of the resulting algorithm grow linearly with the number of tracks. The recursive estimators for the coupled track means and covariance are derived and presented
Syllable-Level Representations of Suprasegmental Features for DNN-Based Text-to-Speech Synthesis

A top-down hierarchical system based on deep neural networks is investigated for the modeling of prosody in speech synthesis. Suprasegmental features are processed separately from segmental features and a compact distributed representation of high-level units is learned at syllable-level. The suprasegmental representation is then integrated into a frame-level network. Ob-jective measures show that balancing segmental and supraseg-mental features can be useful for the frame-level network. Additional features incorporated into the hierarchical system are then tested. At the syllable-level, a bag-of-phones representation is proposed and, at the word-level, embeddings learned from text sources are used. It is shown that the hierarchical system is able to leverage new features at higher-levels more efﬁciently than a system which exploits them directly at the frame-level. A perceptual evaluation of the proposed systems is conducted and followed by a discussion of the results.
Neutrophil-specific Granule Deficiency Results from a Novel Mutation with Loss of Function of the Transcription Factor CCAAT/Enhancer Binding Protein ε

Neutrophil-specific granule deficiency (SGD) is a rare disorder characterized by recurrent pyogenic infections, defective neutrophil chemotaxis and bactericidal activity, and lack of neutrophil secondary granule proteins. CCAAT/enhancer binding protein (C/EBP)ε, a member of the leucine zipper family of transcription factors, is expressed primarily in myeloid cells, and its knockout mouse model possesses distinctive defects, including a lack of neutrophil secondary granule proteins. Sequence analysis of the genomic DNA of a patient with SGD revealed a five-basepair deletion in the second exon of the C/EBPε locus. The predicted frame shift results in a truncation of the 32-kD major C/EBPε isoform, with loss of the dimerization domain, DNA binding region, and transcriptional activity. The multiple functional defects observed in these early neutrophil progenitor cells, a consequence of C/EBPε deficiency, define SGD as a defect in myelopoiesis and establish the requirement for C/EBPε for the promyelocyte–myelocyte transition in myeloid differentiation.
Physiologic Control of IDO Competence in Splenic Dendritic Cells

Dendritic cells (DCs) competent to express the regulatory enzyme IDO in mice are a small but distinctive subset of DCs. Previously, we reported that a high-dose systemic CpG treatment to ligate TLR9 in vivo induced functional IDO exclusively in splenic CD19+ DCs, which stimulated resting Foxp3-lineage regulatory T cells (Tregs) to rapidly acquire potent suppressor activity. In this paper, we show that IDO was induced in spleen and peripheral lymph nodes after CpG treatment in a dose-dependent manner. Induced IDO suppressed local T cell responses to exogenous Ags and inhibited proinflammatory cytokine expression in response to TLR9 ligation. IDO induction did not occur in T cell-deficient mice or in mice with defective B7 or programmed death (PD)-1 costimulatory pathways. Consistent with these findings, CTLA4 or PD-1/PD-ligand costimulatory blockade abrogated IDO induction and prevented Treg activation via IDO following high-dose CpG treatment. Consequently, CD4+CD25+ T cells uniformly expressed IL-17 shortly after TLR9 ligation. These data support the hypothesis that constitutive interactions from activated T cells or Tregs and IDO-competent DCs via concomitant CTLA4→B7 and PD-1→PD-ligand signals maintain the default potential to regulate T cell responsiveness via IDO. Acute disruption of these nonredundant interactions abrogated regulation via IDO, providing novel perspectives on the proinflammatory effects of costimulatory blockade therapies. Moreover, interactions between IDO-competent DCs and activated T cells in lymphoid tissues may attenuate proinflammatory responses to adjuvants such as TLR ligands.
Job stress in the law enforcement sector: comparing the linear, non-linear and interaction effects of working conditions

This study addresses a gap in much of the research involving stress among high-risk occupations by investigating the effects of linear, non-linear and interaction models in a law enforcement organization that has undertaken a series of efficiency-driven organizational reforms. The results of a survey involving 2085 police officers indicated that the demand–control–support model provided good utility in predicting an officer's satisfaction, commitment and well-being. In particular, social support and job control were closely associated with all three outcome variables. Although the demand × control/support interactions were not identified in the data, there was some support for the curvilinear effects of job demands. The results have implications for the organizational conditions that need to be addressed in contemporary policing environments where new public management strategies have had widespread affects on the social and organizational context in which policing takes place. Copyright © 2008 John Wiley & Sons, Ltd.
Cell-free nucleic acids as non-invasive biomarkers of gynecological cancers, ovarian, endometrial and obstetric disorders and fetal aneuploidy.

BACKGROUND Proper folliculogenesis is fundamental to obtain a competent oocyte that, once fertilized, can support the acquisition of embryo developmental competence and pregnancy. MicroRNAs (miRNAs) are crucial regulators of folliculogenesis, which are expressed in the cumulus-oocyte complex and in granulosa cells and some can also be found in the bloodstream. These circulating miRNAs are intensively studied and used as diagnostic/prognostic markers of many diseases, including gynecological and pregnancy disorders. In addition, serum contains small amounts of cell-free DNA (cfDNA), presumably resulting from the release of genetic material from apoptotic/necrotic cells. The quantification of nucleic acids in serum samples could be used as a diagnostic tool for female infertility. METHODS An overview of the published literature on miRNAs, and particularly on the use of circulating miRNAs and cfDNA as non-invasive biomarkers of gynecological diseases, was performed (up to January 2014). RESULTS In the past decade, cell-free nucleic acids have been studied for potential use as biomarkers in many diseases, particularly in gynecological cancers, ovarian and endometrial disorders, as well as in pregnancy-related pathologies and fetal aneuploidy. The data strongly suggest that the concentration of cell-free nucleic acids in serum from IVF patients or in embryo culture medium could be related to the ovarian hormone status and embryo quality, respectively, and be used as a non-invasive biomarker of IVF outcome. CONCLUSIONS The profiling of circulating nucleic acids, such as miRNAs and cfDNA, opens new perspectives for the diagnosis/prognosis of ovarian disorders and for the prediction of IVF outcomes, namely (embryo quality and pregnancy).
Bioavailability and bioactivity of intravenous vs subcutaneous infusion of growth hormone in GH‐deficient patients

OBJECTIVE The bioavailability of GH immunoreactive serum concentrations is reduced following subcutaneous (s.c.) as compared with intravenous (i.v.) administration. Whether this difference also translates into a different biological activity remains to be investigated. The aim of the present study was to evaluate the short‐term metabolic effects of GH following i.v. and s.c. delivery.
Effect of caring for an older person on women's lifetime participation in work

ABSTRACT This paper examines the relationship between informal care and ending paid work for working women of three age groups (up to 30, 31–49 and 50 or more years) in 1995 in Belgium. It explores the effect of being a carer for older adults on the probability of ceasing to work. Most particularly, it focuses on the effect of the care intensity in the different age groups. The analyses use data from the European Community Household Panel (ECHP). A sample of 24,592 working women living in 11 European countries was followed from 1995 to 2001. Multivariate analyses for the entire sample show that the simple fact of caring or not did not influence the probability of ceasing work, but that providing light care had a negative effect, suggesting the presence of a respite effect. As for the effects specific to each age group, caring did not have any effect for women aged 31 to 49 years, but for the other two age groups, women who provided light care were less likely to cease work than those not caring for an older person. In contrast, providing heavy care increased the probability of ceasing work, but only for those aged 50 or more years. The findings suggest that studies of and policies related to informal care and its consequences should give more attention to age group differences.
A Distinct MR Imaging Phenotype in Amyotrophic Lateral Sclerosis: Correlation between T1 Magnetization Transfer Contrast Hyperintensity along the Corticospinal Tract and Diffusion Tensor Imaging Analysis

BACKGROUND AND PURPOSE: In the search for a diagnostic marker in ALS, we focused our attention on the hyperintense signal intensity in T1 MTC MR images along the CST, detected in some patients and not found in other patients with ALS and in control subjects. The aim of this study was to investigate the relationship between the hyperintense signal intensity in T1 MTC images and white matter damage. To this purpose, we studied potential heterogeneities in DTI values within our patients by using TBSS without a priori anatomic information. MATERIALS AND METHODS: In 43 patients with ALS and 43 healthy control subjects, the presence or absence of T1 MTC hyperintense signal intensity was evaluated. With a DTI analysis with a TBSS approach, differences in FA distribution between the 2 groups (patients with T1 MTC hyperintense signal intensity and patients without it) compared with each other and with control subjects were investigated. RESULTS: We found regional differences in white matter FA between patients with T1 MTC hyperintense signal intensity (37.2%) and patients without it. Patients with T1 MTC abnormal signal intensity showed lower FA strictly limited to the motor network and the posterior aspect of the body of the CC without extramotor FA reductions, whereas patients without this sign showed FA reductions in several confluent regions within and outside the CST and in the whole CC. CONCLUSIONS: T1 MTC hyperintense signal intensity in the CST and posterior CC, when present, is specific for ALS and represents, among patients with ALS, a possible distinct phenotype of presentation of the disease with prominent UMN involvement.
Dendritic Cells in Chronic Mycobacterial Granulomas Restrict Local Anti-Bacterial T Cell Response in a Murine Model

Background Mycobacterium-induced granulomas are the interface between bacteria and host immune response. During acute infection dendritic cells (DCs) are critical for mycobacterial dissemination and activation of protective T cells. However, their role during chronic infection in the granuloma is poorly understood. Methodology/Principal Findings We report that an inflammatory subset of murine DCs are present in granulomas induced by Mycobacteria bovis strain Bacillus Calmette-guerin (BCG), and both their location in granulomas and costimulatory molecule expression changes throughout infection. By flow cytometric analysis, we found that CD11c+ cells in chronic granulomas had lower expression of MHCII and co-stimulatory molecules CD40, CD80 and CD86, and higher expression of inhibitory molecules PD-L1 and PD-L2 compared to CD11c+ cells from acute granulomas. As a consequence of their phenotype, CD11c+ cells from chronic lesions were unable to support the reactivation of newly-recruited, antigen 85B-specific CD4+IFNγ+ T cells or induce an IFNγ response from naïve T cells in vivo and ex vivo. The mechanism of this inhibition involves the PD-1:PD-L signaling pathway, as ex vivo blockade of PD-L1 and PD-L2 restored the ability of isolated CD11c+ cells from chronic lesions to stimulate a protective IFNγ T cell response. Conclusions/Significance Our data suggest that DCs in chronic lesions may facilitate latent infection by down-regulating protective T cell responses, ultimately acting as a shield that promotes mycobacterium survival. This DC shield may explain why mycobacteria are adapted for long-term survival in granulomatous lesions.
Nurse and Nurse Assistant Perceptions of Missed Nursing Care: What Does It Tell Us About Teamwork?

Missed nursing care is a pervasive problem in acute care hospitals as is dysfunctional nursing teamwork. Given that teamwork has a significant impact on healthcare quality and patient safety, the author reports findings from a study that examined differences in perceptions between RNs and nursing assistants as to the extent of missed nursing care and the reasons for missing that care. Study findings point to a lack of essential elements of teamwork (ie, closed-looped communication, leadership, team orientation, trust, and shared mental models). The author analyzes what this reveals about teamwork between these 2 groups of nursing personnel who work side by side caring for the same patients and offers specific interventions.
Gamma-glutamyltransferase predicts increased risk of mortality: A systematic review and meta-analysis of prospective observational studies

Abstract The aim of this study was to evaluate the association between gamma-glutamyltransferase (GGT) and mortality through a comprehensive analysis of existing evidence. PubMed, Embase, Chinese Biomedical Literature, and Science Citation Index databases were electronically searched. Studies were included if the study design was prospective and included reference and at-risk levels of GGT at baseline and mortality as a separate outcome. The quality of the studies included was assessed on the basis of Newcastle–Ottawa scale. Data from selected qualified studies were systematically reviewed, pooled, and analyzed according to the MOOSE guidelines and PRISMA statement. The results included the following: 1. 35 studies including 571 511 participants and 72 196 cases of mortality; 2. GGT, even at physiologic levels, was associated with increased all-cause mortality and cardiovascular mortality, and might also be associated with cancer-related mortality in the general population; and 3. GGT was very likely to be associated with all-cause mortality and cardiovascular mortality in patients with coronary artery disease and type 2 diabetes mellitus. Many of the studies included did not specifically exclude subjects with hepatic diseases or alcohol abuse, which may have obscured the results. Moderate heterogeneity was observed in the meta-analysis of GGT and all-cause mortality. Different compositions of cause-specific mortality might be the reason. However, subgroup analysis could only be performed on cardiovascular death because of insufficient information. GGT, even at physiologic high levels, predicted mortality, especially cardiovascular mortality and cancer mortality. The underlining mechanism and potential effects of GGT-targeted intervention on health warrant further investigation.
Making the Most of Time and Talent: Secondary School Organizational Climates, Teaching Task Environments, and Teacher Commitment

The relationships among teachers’ task environments, more general characteristics of school organizational climates, and teachers’ professional and organizational commitments were examined. Data were derived from the 1987–1988 National Center for Education Statistics Schools and Staffing Survey; the study was based on a sample of 14,844 secondary school teachers. Task environment was operationalized in terms of structural features of teachers’ class schedules, and school climate was measured in terms of administrative support, teacher influence and autonomy, and collegiality. Results suggest that, while teachers’ professional commitment and organizational commitment were unrelated to teachers’ class schedules, commitment was associated with school climate.