Miracle-dz/UniFAR-FTUs huggingface dataset:
Unconscious Conflict in the Light of Contemporary Psychoanalytic Findings

In considering unconscious conflict, the author looks at the influence of contemporary psychoanalytic findings on the formulation and treatment of various psychopathologies. Technical considerations related to furthering the understanding of unconscious conflict are addressed, with attention to the roles of drives and affects, and to the influence of deficit theories and other developments on current psychoanalytic thinking and practice. A brief clinical illustration is included.
Intracluster Device-to-Device Relay Algorithm With Optimal Resource Utilization

Device-to-device (D2D) communications help improve the performance of wireless multicast services in cellular networks via cooperative retransmissions among multicast recipients within a cluster. Resource utilization efficiency should be taken into account in the design of D2D communication systems. To maximize resource efficiency of D2D retransmissions, there is a tradeoff between multichannel diversity and multicast gain. In this paper, by analyzing the relationship between the number of relays and minimal time-frequency resource cost on retransmissions, we derive a closed-form probability density function (pdf) for an optimal number of D2D relays. Motivated by the analysis, we then propose an intracluster D2D retransmission scheme with optimized resource utilization, which can adaptively select the number of cooperative relays performing multicast retransmissions and give an iterative subcluster partition algorithm to enhance retransmission throughput. Exploiting both multichannel diversity and multicast gain, the proposed scheme achieves a significant gain in terms of resource utilization if compared with its counterparts with a fixed number of relays.
Neural Basis of Enhanced Executive Function in Older Video Game Players: An fMRI Study

Video games have been found to have positive influences on executive function in older adults; however, the underlying neural basis of the benefits from video games has been unclear. Adopting a task-based functional magnetic resonance imaging (fMRI) study targeted at the flanker task, the present study aims to explore the neural basis of the improved executive function in older adults with video game experiences. Twenty video game players (VGPs) and twenty non-video game players (NVGPs) of 60 years of age or older participated in the present study, and there are no significant differences in age (t = 0.62, p = 0.536), gender ratio (t = 1.29, p = 0.206) and years of education (t = 1.92, p = 0.062) between VGPs and NVGPs. The results show that older VGPs present significantly better behavioral performance than NVGPs. Older VGPs activate greater than NVGPs in brain regions, mainly in frontal-parietal areas, including the right dorsolateral prefrontal cortex, the left supramarginal gyrus, the right angular gyrus, the right precuneus and the left paracentral lobule. The present study reveals that video game experiences may have positive influences on older adults in behavioral performance and the underlying brain activation. These results imply the potential role that video games can play as an effective tool to improve cognitive ability in older adults.
The Conundrum of Chronic Kidney Disease Classification and End-Stage Renal Risk Prediction in the Elderly – What Is the Right Approach?

The worldwide high prevalence of chronic kidney disease (CKD) and the increasing number of patients reaching end-stage renal disease (ESRD) are a matter of major concern. The most widely accepted classification system of CKD is that proposed by the Kidney Disease Outcomes Quality Initiative (KDOQI) in 2002. When applying this system, it has become apparent that the prevalence of CKD is particularly high in elderly subjects. The fact that this system is mainly based on estimated glomerular filtration rate (eGFR), subdividing the severity of CKD into five stages, is a matter of debate. A main issue is that although a reduced eGFR is often encountered in elderly subjects, most of these subjects do not have a renal disease leading to an increased risk of ESRD, i.e. the predictive power of ESRD is unsatisfactory. Recent advances have been put forward to improve (1) estimation of GFR and (2) prediction of ESRD. In this review, we discuss the currently available data with a focus on the elderly and propose an improved classification system of CKD which is characterized by a substantially better diagnostic accuracy for progression to ESRD. This is simply and cost-effectively accomplished by subdividing stage 3 CKD into two groups (eGFR 30–44 and 45–59 ml/min/1.73 m2) and by complementing all levels of eGFR with information about urinary albumin excretion, i.e. whether normoalbuminuria, microalbuminuria, or macroalbuminuria is present. The consequence should be a revision of the 2002 KDOQI CKD classification system according to these findings, which would be a significant step forward, particularly for elderly CKD patients.
Measurement and Analysis of TCP Throughput Collapse in Cluster-based Storage Systems

Cluster-based and iSCSI-based storage systems rely on standard TCP/IP-over-Ethernet for client access to data. Unfortunately, when data is striped over multiple networked storage nodes, a client can experience a TCP throughput collapse that results in much lower read bandwidth than should be provided by the available network links. Conceptually, this problem arises because the client simultaneously reads fragments of a data block from multiple sources that together send enough data to overload the switch buffers on the client's link. This paper analyzes this Incast problem, explores its sensitivity to various system parameters, and examines the effectiveness of alternative TCP- and Ethernet-level strategies in mitigating the TCP throughput collapse.
1H Magnetic Resonance Spectroscopy Findings in Idiopathic Inflammatory Myopathies at 3 T: Feasibility and First Results

ObjectiveThe aim of this study was to investigate the feasibility and potential use of quantitative proton magnetic resonance spectroscopy (MRS) for determining metabolite concentrations in patients with suspected inflammatory myopathies. Materials and MethodsIn this institutional review board–approved, Health Insurance Portability and Accountability Act-compliant prospective study, 35 patients with a suspected inflammatory myopathy and 6 age-matched healthy volunteers underwent magnetic resonance imaging (MRI) (T1-weighted and short tau inversion recovery [STIR] sequences) and single-voxel MRS (point-resolved spectroscopy; repetition time/echo time, 2000/135 milliseconds; voxel size, 2.0 × 2.0 × 4.0 cm3) at 3 T. The voxel was placed in a thigh muscle and targeted to one with abnormal STIR signal when possible. Absolute trimethylamine, creatine (Cr), and bulk lipid concentrations in each voxel were determined using the phantom replacement method. The MRS results of patients and healthy subjects were compared using the Wilcoxon rank sum test. ResultsTwenty-one patients were diagnosed with an active idiopathic inflammatory myopathy (IIM). In 20 of these patients, MRI showed increased intramuscular STIR signal; however, the muscle where the voxel was placed was normal in 9 patients. Patients with an IIM demonstrated higher mean intramuscular Cr concentration compared with controls (62.1 vs 35.3 IU; P = 0.01), but there were no differences in the mean trimethylamine or lipid concentrations. In IIM patients with no intravoxel signal abnormality (9/21), the mean Cr concentration was still higher than that in healthy subjects (63.2 vs 35.3 IU; P = 0.001). ConclusionsQuantitative 3-T MRS is feasible and may supplement the role of conventional MRI in the evaluation of patients with inflammatory myopathies, especially where MRI shows no obvious muscle abnormalities.
Using motion capture to recognize affective states in humans

Humans convey and recognize affective states from a broad spectrum of verbal and nonverbal modalities. An historical focus on face as a primary modality for conveying and recognizing emotions spurred the computer science community to research methods for computer systems to automatically recognize emotions from facial expressions. Today, the Facial Action Coding System (FACS) [1] is the most popular standard for systematically categorising (facial) expressions of emotions. Recent psychology studies, however, have revealed that another form of nonverbal communication, body posture, can prove a very good indicator for various categories of emotion. Whilst these studies have been used rather effectively to enable artificial systems to express affective behaviour through posture (e.g., Sony’s AIBO), posture still has no equivalent to FACS and most existing studies use only coarse-grained posture descriptors (e.g. leaning forward, slumping back).
Bayesian learning of measurement and structural models

We present a Bayesian search algorithm for learning the structure of latent variable models of continuous variables. We stress the importance of applying search operators designed especially for the parametric family used in our models. This is performed by searching for subsets of the observed variables whose covariance matrix can be represented as a sum of a matrix of low rank and a diagonal matrix of residuals. The resulting search procedure is relatively efficient, since the main search operator has a branch factor that grows linearly with the number of variables. The resulting models are often simpler and give a better fit than models based on generalizations of factor analysis or those derived from standard hill-climbing methods.
A Torque Ripple Compensation Technique for a Low-Cost Brushless DC Motor Drive

This paper presents a torque ripple compensation technique for a brushless dc (BLDC) motor drive that is operated without a DC link capacitor. The motor drive, which uses a single-switch control strategy, resembles that of a buck converter during operation at any switching state. A simple buck-converter-based model is therefore proposed to predict the behavior of the BLDC motor drive at constant speed. Using the model, the impact of operation without the DC link capacitor on the torque produced by the BLDC motor drive is investigated in detail. Theoretical behavior of the BLDC motor drive is compared with MATLAB/Simulink-based simulations to demonstrate the validity of the compensation technique and the analysis. Experimental results of a 250 W prototype motor drive are also presented to further validate the theoretical analysis, as well as the effectiveness of the proposed technique. Results convincingly indicate that the BLDC motor drive with torque ripple compensation offers comparable performance.
The Effects of Witness Viewpoint Distance, Angle, and Choice on Eyewitness Accuracy in Police Lineups Conducted in Immersive Virtual Environments

The current study investigated the value of using immersive virtual environment technology as a tool for assessing eyewitness identification. Participants witnessed a staged crime and then examined sequential lineups within immersive virtual environments that contained 3D virtual busts of the suspect and six distractors. Participants either had unlimited viewpoints of the busts in terms of angle and distance, or a unitary view at only a single angle and distance. Furthermore, participants either were allowed to choose the angle and distance of the viewpoints they received, or were given viewpoints without choice. Results demonstrated that unlimited viewpoints improved accuracy in suspect-present lineups but not in suspect-absent lineups. Furthermore, across conditions, post-hoc measurements demonstrated that when the chosen view of the suspect during the lineup was similar to the view during the staged crime in terms of distance, accuracy improved. Finally, participants were more accurate in suspect-absent lineups than in suspect-present lineups. Implications of the findings in terms of theories of eyewitness testimony are discussed, as well as the value of using virtual lineups that elicit high levels of presence in the field. We conclude that digital avatars of higher fidelity may be necessary before actually implementing virtual lineups.
Penetration of guinea pig skin by acyclovir in different vehicles and correlation with the efficacy of topical therapy of experimental cutaneous herpes simplex virus infection

Inadequate penetration of antiviral agents through the stratum corneum of the skin may be one of the limiting factors in the topical therapy of recurrent cutaneous herpes simplex virus infections in humans. In vitro studies of the penetration of the nucleoside analog acyclovir (ACV) through guinea pig skin demonstrated a marked increase in drug flux when ACV was formulated in dimethyl sulfoxide (DMSO), compared with water or polyethylene glycol (PEG) as the vehicle. To examine whether the increased transcutaneous flux of ACV effected by DMSO was meaningful in vivo, topical 5% ACV in DMSO was evaluated for the treatment of cutaneous herpes simplex virus infection in guinea pigs and compared with topical 5% ACV in PEG. When compared with infection sites treated with the vehicle alone, ACV in DMSO produced a greater percent reduction than did ACV in PEG in median lesion number (8 versus 58%; P less than 0.001), median lesion area (35 versus 73%; P = 0.001), and median lesion virus titer (21 versus 84%; P = 0.08). We conclude that DMSO is a highly effective vehicle for topical administration of ACV and is superior to PEG in our model. Careful choice of vehicle and consideration of transcutaneous penetration may be important for realization of the full potential of topical antiviral therapy in humans.
Influence of size, shape and core–shell interface on surface plasmon resonance in Ag and Ag@MgO nanoparticle films deposited on Si/SiOx

Ag and Ag@MgO core–shell nanoparticles (NPs) with a diameter of d = 3–10 nm were obtained by physical synthesis methods and deposited on Si with its native ultrathin oxide layer SiOx (Si/SiOx). Scanning electron microscopy and transmission electron microscopy (TEM) images of bare Ag NPs revealed the presence of small NP aggregates caused by diffusion on the surface and agglomeration. Atomic resolution TEM gave evidence of the presence of crystalline multidomains in the NPs, which were due to aggregation and multitwinning occurring during NP growth in the nanocluster source. Co-deposition of Ag NPs and Mg atoms in an oxygen atmosphere gave rise to formation of a MgO shell matrix surrounding the Ag NPs. The behaviour of the surface plasmon resonance (SPR) excitation in surface differential reflectivity (SDR) spectra with p-polarised light was investigated for bare Ag and Ag@MgO NPs. It was shown that the presence of MgO around the Ag NPs caused a red shift of the plasmon excitation, and served to preserve its existence after prolonged (five months) exposure to air, realizing the possibility of technological applications in plasmonic devices. The Ag NP and Ag@MgO NP film features in the SDR spectra could be reproduced by classical electrodynamics simulations by treating the NP-containing layer as an effective Maxwell Garnett medium. The simulations gave results in agreement with the experiments when accounting for the experimentally observed aggregation.
The Crystal Structure of the Fifth Scavenger Receptor Cysteine-Rich Domain of Porcine CD163 Reveals an Important Residue Involved in Porcine Reproductive and Respiratory Syndrome Virus Infection

ABSTRACT Porcine reproductive and respiratory syndrome (PRRS) has become an economically critical factor in swine industry since its worldwide spread in the 1990s. Infection by its causative agent, PRRS virus (PRRSV), was proven to be mediated by an indispensable receptor, porcine CD163 (pCD163), and the fifth scavenger receptor cysteine-rich domain (SRCR5) is essential for virus infection. However, the structural details and specific residues of pCD163 SRCR5 involved in infection have not been defined yet. In this study, we prepared recombinant pCD163 SRCR5 in Drosophila melanogaster Schneider 2 (S2) cells and determined its crystal structure at a high resolution of 2.0 Å. This structure includes a markedly long loop region and shows a special electrostatic potential, and these are significantly different from those of other members of the scavenger receptor cysteine-rich superfamily (SRCR-SF). Subsequently, we carried out structure-based mutational studies to identify that the arginine residue at position 561 (Arg561) in the long loop region is important for PRRSV infection. Further, we showed Arg561 probably takes effect on the binding of pCD163 to PRRSV during virus invasion. Altogether the current work provides the first view of the CD163 SRCR domain, expands our knowledge of the invasion mechanism of PRRSV, and supports a molecular basis for prevention and control of the virus. IMPORTANCE PRRS has caused huge economic losses to pig farming. The syndrome is caused by PRRSV, and PRRSV infection has been shown to be mediated by host cell surface receptors. One of them, pCD163, is especially indispensable, and its SRCR5 domain has been further demonstrated to play a significant role in virus infection. However, its structural details and the residues involved in infection are unknown. In this study, we determined the crystal structure of pCD163 SRCR5 and then carried out site-directed mutational studies based on the crystal structure to elucidate which residue is important. Our work not only provides structural information on the CD163 SRCR domain for the first time but also indicates the molecular mechanism of PRRSV infection and lays a foundation for future applications in prevention and control of PRRS.
Of Financial And Strategic Decisions Volume 10 Number 3 Fall 1997 63 CORPORATE MANAGERS ’ RISKY BEHAVIOR : RISK TAKING OR AVOIDING ?

This study reports on five experiments that investigate professional corporate managers’ risky behavior across decision settings in which various forms of financial data are evaluated. Specifically, managers decisions to take or avoid risk are investigated when evaluating data in the form of profits, losses, revenues, costs, and expenditures. The results indicate that, with one exception (i.e., clear financial losses), a greater tendency towards risk avoidance exists when managers evaluate many forms of financial data. These results provide evidence on managerial risky behavior across decision contexts and suggest that managers use inclusive “mental accounts” in their decision processes.
Protein Kinase C ζ Phosphorylates a Subset of Selective Sites of the NADPH Oxidase Component p47phox and Participates in Formyl Peptide-Mediated Neutrophil Respiratory Burst

Generation of superoxide anion by the multiprotein complex NADPH phagocyte oxidase is accompanied by extensive phosphorylation of its 47-kDa protein component, p47phox, a major cytosolic component of this oxidase. Protein kinase C ζ (PKC ζ), an atypical PKC isoform expressed abundantly in human polymorphonuclear leukocytes (PMN), translocates to the PMN plasma membrane upon stimulation by the chemoattractant fMLP. We investigated the role of PKC ζ in p47phox phosphorylation and in superoxide anion production by human PMN. In vitro incubation of recombinant p47phox with recombinant PKC ζ induced a time- and concentration-dependent phosphorylation of p47phox with an apparent Km value of 2 μM. Phosphopeptide mapping analysis of p47phox showed that PKC ζ phosphorylated fewer selective sites in comparison to “conventional” PKCs. Serine 303/304 and serine 315 were identified as targets of PKC ζ by site-directed mutagenesis. Stimulation of PMN by fMLP induced a rapid and sustained plasma membrane translocation of PKC ζ that correlated to that of p47phox. A cell-permeant-specific peptide antagonist of PKC ζ inhibited both fMLP-induced phosphorylation of p47phox and its membrane translocation. The antagonist also inhibited the fMLP-induced production of oxidant (IC50 of 10 μM), but not that induced by PMA. The inhibition of PKC ζ expression in HL-60 neutrophil-like cells using antisense oligonucleotides (5 and 10 μM) inhibited fMLP-promoted oxidant production (27 and 50%, respectively), but not that induced by PMA. In conclusion, p47phox is a substrate for PKC ζ and participates in the signaling cascade between fMLP receptors and NADPH oxidase activation.
Visual field testing with the new Humphrey Matrix: a comparison between the FDT N-30 and Matrix N-30-F tests.

PURPOSE To determine if the N-30-F test with the new Humphrey Matrix instrument is comparable to the traditional frequency-doubling technology (FDT) N-30 test. METHODS A sample of 47 eyes from 47 patients (five normal subjects, 27 with ocular hypertension and 15 with glaucoma) underwent visual field (VF) testing with standard automated perimetry, and with FDT, using the FDT N-30 program, and the Matrix N-30-F program (using the same 19 tested points, full-threshold strategy, but with an enhanced algorithm to reduce testing time). The plots, mean deviation (MD), pattern standard deviation (PSD), defect locations and test time were compared. RESULTS The agreement between the two tests was shown to be good, except for subjects with large VF defects, in which greater PSD values were observed with the FDT test, whereas the Matrix test gave a higher MD and number of abnormal test locations in the total deviation plot. A lack of agreement was also found for the number of abnormal test locations on the pattern deviation plot at any VF loss severity level. The test time for the Matrix test was significantly shorter. CONCLUSION The FDT N-30 and Matrix N-30-F tests proved to be comparable in cases of early to moderate VF defects.
A New Approach to Probabilistic Programming Inference

We introduce and demonstrate a new approach to inference in expressive probabilistic programming languages based on particle Markov chain Monte Carlo. Our approach is simple to implement and easy to parallelize. It applies to Turing-complete probabilistic programming languages and supports accurate inference in models that make use of complex control ow, including stochastic recursion. It also includes primitives from Bayesian nonparametric statistics. Our experiments show that this approach can be more ecient than previously introduced single-site Metropolis-Hastings methods.