Miracle-dz/UniFAR-FTUs huggingface dataset:
Apolipoprotein (apo) E4 enhances HIV-1 cell entry in vitro, and the APOE ε4/ε4 genotype accelerates HIV disease progression

Originally recognized for their role in lipoprotein metabolism and cardiovascular disease, apolipoprotein (apo) E isoforms (apoE2, apoE3, and apoE4) have also been implicated to play a key role in several biological processes not directly related to their lipid transport function. For example, apoE4 contributes significantly to neurodegeneration in Alzheimer's disease. However, the role of apoE in infectious diseases is less well defined. Here, by examining a large cohort of HIV+ European and African American subjects, we found that the APOE ε4/ε4 genotype is associated with an accelerated disease course and especially progression to death compared with the APOE ε3/ε3 genotype. However, an association between the ε4/ε4 genotype and HIV-associated dementia (HAD), a neurological condition with clinicopathological features similar to Alzheimer's disease, was not detected. Consistent with the genotype–phenotype relationships observed, compared with recombinant apoE3, apoE4 enhanced HIV fusion/cell entry of both R5 and X4 HIV strains in vitro. These findings establish apoE as a determinant of HIV-AIDS pathogenesis and raise the possibility that current efforts to convert apoE4 to an “apoE3-like” molecule to treat Alzheimer's disease might also have clinical applicability in HIV disease.
Classifying User Forum Participants: Separating the Gurus from the Hacks, and Other Tales of the Internet

This paper introduces a novel user classification task in the context of web user forums. We present a definition of four basic user characteristics and an annotated dataset. We outline a series of approaches for predicting user characteristics, utilising aggregated post features and user/thread network analysis in a supervised learning context. Using the proposed feature sets, we achieve results above both a naive baseline and a bag-ofwords approach, for all four of our basic user characteristics. In all cases, our bestperforming classifier is statistically indistinct from an upper bound based on the inter-annotator agreement for the task.
Perirhinal Cortex Contributes to Accuracy in Recognition Memory and Perceptual Discriminations

The prevailing view of the medial temporal lobe (MTL) holds that its structures are dedicated to long-term declarative memory. Recent evidence challenges this position, suggesting that perirhinal cortex (PRc) in the MTL may also play a role in perceptual discriminations of stimuli with substantial visual feature overlap. Relevant neuropsychological findings in humans have been inconclusive, likely because studies have relied on patients with large and variable MTL lesions. Here, we conducted a functional magnetic resonance imaging study in healthy individuals to determine whether PRc shows a performance-related involvement in perceptual oddball judgments that is comparable to its established role in recognition memory. Morphed faces were selected as stimuli because of their large degree of feature overlap. All trials involved presentation of displays with three faces. The perceptual oddball task required identification of the face least similar to the other display members. The memory task involved forced-choice recognition of a previously studied face. When levels of behavioral performance were matched, we observed comparable levels of activation in right PRc for both tasks. Moreover, right PRc activity differentiated between accurate and inaccurate trials in both tasks. Together these results indicate that declarative memory demands are not a prerequisite for a performance-related engagement of PRc and that the introduction of such declarative memory demands in an otherwise closely matched perceptual task does not necessarily lead to an increase in PRc involvement. As such our findings show that declarative memory and perception are not as clearly separable at the level of MTL functioning as traditionally thought.
Reporting Rule and Firm Efficiency

We examine whether the R&D reporting rule that requires expensing of R&D as incurred leads to longerterm operational inefficiency for firms. In Germany, the R&D reporting rule changed from immediate expensing to partial capitalization when Germany adopted IFRS in 2005. We examine the same German firms before and after the IFRS adoption. The German setting and the design of using each firm as its own control likely mitigate concerns regarding self-selection and omitted firm attributes. We employ Stochastic Frontier Analysis and Data Envelopment Analysis to generate firm-specific efficiency measures. We find that efficiency of German firms improved significantly in the post-IFRS period relative to the pre period. We, however, find no evidence of efficiency gains for a control sample of companies that have never reported R&D. Our results are robust to a battery of sensitivity tests suggesting that partial capitalization of R&D is the likely catalyst for the efficiency improvement. JEL Classifications: G15; G38; M48
The Relationship Between Work-Life Balance Initiatives and Organizational Citizenship Behavior: The Mediating Role of Perceived Organizational Support

INTRODUCTION Khurram Shakir1 Siraj Jamal Siddiqui2 1IQRA University, Karachi, Pakistan Email: khurramshakir@yahoo.com 2IQRA University, Karachi, Pakistan Work-Life Balance and Organization Citizenship Behavior are phenomena that have been subjects of constant research amongst organization behavior theorists since 1970’s. The paradigm shift in the economy has made it clear to the organizations that the only way to compete and survive in this global market is their human resource, as all the efforts to gain competitive edge are dependent on their performance and productivity. Organ (2018), corroborates that scholarship in the area of OCB has enriched significantly in the last 20 years, expanding its associations to culture, attitudes, personality, mood state, stress, and organizational performance. JEL Classification: M50, M51, M52, M53, M54
The RNA-binding protein bicaudal C regulates polycystin 2 in the kidney by antagonizing miR-17 activity

The RNA-binding protein Bicaudal C is an important regulator of embryonic development in C. elegans, Drosophila and Xenopus. In mouse, bicaudal C (Bicc1) mutants are characterized by the formation of fluid-filled cysts in the kidney and by expansion of epithelial ducts in liver and pancreas. This phenotype is reminiscent of human forms of polycystic kidney disease (PKD). Here, we now provide data that Bicc1 functions by modulating the expression of polycystin 2 (Pkd2), a member of the transient receptor potential (TRP) superfamily. Molecular analyses demonstrate that Bicc1 acts as a post-transcriptional regulator upstream of Pkd2. It regulates the stability of Pkd2 mRNA and its translation efficiency. Bicc1 antagonized the repressive activity of the miR-17 microRNA family on the 3′UTR of Pkd2 mRNA. This was substantiated in Xenopus, in which the pronephric defects of bicc1 knockdowns were rescued by reducing miR-17 activity. At the cellular level, Bicc1 protein is localized to cytoplasmic foci that are positive for the P-body markers GW182 and HEDLs. Based on these data, we propose that the kidney phenotype in Bicc1−/− mutant mice is caused by dysregulation of a microRNA-based translational control mechanism.
The soluble proteome of tobacco Bright Yellow-2 cells undergoing H2O2-induced programmed cell death

Plant programmed cell death (PCD) is a genetically controlled process that plays an important role in development and stress responses. Reactive oxygen species (ROS) are key inducers of PCD. The addition of 50 mM H2O2 to tobacco Bright Yellow-2 (TBY-2) cell cultures induces PCD. A comparative proteomic analysis of TBY-2 cells treated with 50 mM H2O2 for 30 min and 3 h was performed. The results showed early down-regulation of several elements in the cellular redox hub and inhibition of the protein repair–degradation system. The expression patterns of proteins involved in the homeostatic response, in particular those associated with metabolism, were consistently altered. The changes in abundance of several cytoskeleton proteins confirmed the active role of the cytoskeleton in PCD signalling. Cells undergoing H2O2-induced PCD fail to cope with oxidative stress. The antioxidant defence system and the anti-PCD signalling cascades are inhibited. This promotes a genetically programmed cell suicide pathway. Fifteen differentially expressed proteins showed an expression pattern similar to that previously observed in TBY-2 cells undergoing heat shock-induced PCD. The possibility that these proteins are part of a core complex required for PCD induction is discussed.
Cutting Through the Noise : Defining Ground Truth in Information Credibility on Twitter

Increased popularity of microblogs in recent years brings about a need for better mechanisms to extract credible or otherwise useful information from noisy and large data. While there are a great number of studies that introduce methods to find credible data, there is no accepted credibility benchmark. As a result, it is hard to compare different studies and generalize from their findings. In this paper, we argue for a methodology for making such studies more useful to the research community. First, the underlying ground truth values of credibility must be reliable. The specific constructs used to define credibility must be carefully identified. Secondly, the underlying network context must be quantified and documented. To illustrate these two points, we conduct a unique credibility study of two different data sets on the same topic, but with different network characteristics. We also conduct two different user surveys, and construct two additional indicators of credibility based on retweet behavior. Through a detailed statistical study, we first show that survey based methods can be extremely noisy and results may vary greatly from survey to survey. However, by combining such methods with retweet behavior, we can incorporate two signals that are noisy but uncorrelated, resulting in ground truth measures that can be predicted with high accuracy and are stable across different data sets and survey methods. Newsworthiness of tweets can be a useful frame for specific applications, but it is not necessary for achieving reliable credibility ground truth measurements. We also show that the underlying model for predicting credibility can differ depending on the underlying network context, which needs to be clearly identified and reported in credibility studies to improve their impact.
Gender, Sexual Orientation, and Behavioral Norms in the Labor Market

The author examines bias and behavioral norms based on sex and sexual orientation in the labor market. Using an online laboratory setting, participants were asked to evaluate résumés that were manipulated on sex, perceived LGBT status, and use of traditionally masculine or feminine adjectives. Findings show that male participants penalized résumés that included an LGBT activity, and the penalty was slightly stronger for male résumés. Additionally, men evaluated non-LGBT women who used feminine adjectives more positively than when they used masculine adjectives. Résumés of women with the LGBT activity and men were both immune to this effect. This outcome suggests that perceived-heterosexual women are discouraged from masculine behavior that would be rewarded in the labor market, whereas perceived-LGBT women are not. Men who had the strongest reaction to perceived-heterosexual women using masculine adjectives also had the strongest negative reaction to résumés with an LGBT activity. This pattern suggests that male decision makers are biased in ways that harm LGBT men, LGBT women, and heterosexual women in the labor market.
What Does Physical Rotation Reveal About Mental Rotation?

In a classic psychological science experiment, Shepard and Metzler (1971) discovered that the time participants took to judge whether two rotated abstract block figures were identical increased monotonically with the figures’ relative angular disparity. They posited that participants rotate mental images to achieve a match and that mental rotation recruits motor processes. This interpretation has become central in the literature, but until now, surprisingly few researchers have compared mental and physical rotation. We had participants rotate virtual Shepard and Metzler figures mentally and physically; response time, accuracy, and real-time rotation data were collected. Results suggest that mental and physical rotation processes overlap and also reveal novel conclusions about physical rotation that have implications for mental rotation. Notably, participants did not rotate figures to achieve a match, but rather until they reached an off-axis canonical difference, and rotational strategies markedly differed for judgments of whether the figures were the same or different.
STEM in Fashion Design: The Roles of Creative Self-Efficacy and Epistemic Curiosity in Creative Performance

Integrated learning of STEM (science, technology, engineering, and mathematics) has become a challenge in the field of technical education. To understand the effect of STEM learning, in this study, we first identified the components of STEM in relation to bag design, then asked students to learn STEM knowledge as they designed bags. In this context, we explored how learners’ creative self-efficacy (CSE) related to two types of epistemic curiosity (EC) (i.e., interest type and deprivation type) and reflected the STEM knowledge they acquired and their creative performance (i.e., novelty, utility, and aesthetics). The data were subjected to confirmatory factor analysis with structural equation modeling. The results revealed that CSE was positively related to two types of EC, and knowledge acquired was positively related to creative performance. The indirect correlates between CSE and knowledge acquired, EC and creative performance, and CSE and creative performance were positively mediated by other constructs. The implication of this research is that integrating STEM into the study of fashion design can improve students’ creative performance.
Technology Outsourcing in the U.S. and Japan

OVERVIEW: Technology-intensive companies in the United States and Japan are increasingly turning to external sources for technology needed for new competitive products. Management techniques to fully exploit externally sourced technology are still evolving. So far, most of the activity has been confined to the tactical, business unit level for new products on a case-by-case basis. Some firms are convinced that sustained competitive advantage can be obtained through a strategic approach to technology outsourcing. The path to competitive advantage may be through the coupling of a balanced internal/external technology strategy with a broad portfolio of tactical management techniques.
Self-censorship in social networking sites (SNSs) - privacy concerns, privacy awareness, perceived vulnerability and information management

Purpose This paper aims to investigate behavioural changes related to self-censorship (SC) in social networking sites (SNSs) as new methods of online surveillance are introduced. In particular, it examines the relationships between SC and four related factors: privacy concerns (PC), privacy awareness (PA), perceived vulnerability (PV) and information management (IM). Design/methodology/approach A national wide survey was conducted in the UK (N = 519). The data were analysed to present both descriptive and inferential statistical findings. Findings The level of online SC increases as the level of privacy concern increases. The level of privacy concern increases as the levels of PA and PV increase and the level of effective IM decreases. Originality/value This study extends the literature on online SC, showing that PCs increase the level of SC in SNSs. It provides support for three antecedent factors to PC which impact upon levels of SC when communicating in SNSs.
Ghostwriters on the Court?

A common refrain among Supreme Court watchers is that today it is law clerks who are primarily responsible for drafting the justices’opinions. We search for traces of clerical drafting—identifiable stylistic “fingerprints”—in the first drafts of the opinions that two justices, Lewis F. Powell Jr., and Thurgood Marshall, circulated during the 1985 term of the Court. These two justices relied on their clerks to a different degree: Powell’s office procedures called for him and several clerks to participate in writing each opinion, whereas Marshall reputedly delegated most writing responsibilities to his clerks. We do detect the clerks’ distinct styles in the justices’ opinions, though; as expected, the fingerprints are clearer for Marshall’s clerks than for Powell’s. We also find differences across opinion type, with the clerks’unique style most easily discernible in separate opinions, as opposed to majority opinions.
Hypoalbuminemia Is a Strong Predictor of 30-Day All-Cause Mortality in Acutely Admitted Medical Patients: A Prospective, Observational, Cohort Study

Objective Emergency patients with hypoalbuminemia are known to have increased mortality. No previous studies have, however, assessed the predictive value of low albumin on mortality in unselected acutely admitted medical patients. We aimed at assessing the predictive power of hypoalbuminemia on 30-day all-cause mortality in a cohort of acutely admitted medical patients. Methods We included all acutely admitted adult medical patients from the medical admission unit at a regional teaching hospital in Denmark. Data on mortality was extracted from the Danish Civil Register to ensure complete follow-up. Patients were divided into three groups according to their plasma albumin levels (0–34, 35–44 and ≥45 g/L) and mortality was identified for each group using Kaplan-Meier survival plot. Discriminatory power (ability to discriminate patients at increased risk of mortality) and calibration (precision of predictions) for hypoalbuminemia was determined. Results We included 5,894 patients and albumin was available in 5,451 (92.5%). A total of 332 (5.6%) patients died within 30 days of admission. Median plasma albumin was 40 g/L (IQR 37–43). Crude 30-day mortality in patients with low albumin was 16.3% compared to 4.3% among patients with normal albumin (p<0.0001). Patients with low albumin were older and admitted for a longer period of time than patients with a normal albumin, while patients with high albumin had a lower 30-day mortality, were younger and were admitted for a shorter period. Multivariable logistic regression analyses confirmed the association of hypoalbuminemia with mortality (OR: 1.95 (95% CI: 1.31–2.90)). Discriminatory power was good (AUROC 0.73 (95% CI, 0.70–0.77)) and calibration acceptable. Conclusion We found hypoalbuminemia to be associated with 30-day all-cause mortality in acutely admitted medical patients. Used as predictive tool for mortality, plasma albumin had acceptable discriminatory power and good calibration.
Explicit Bounds for the Pseudospectra of Various Classes of Matrices and Operators

We study the $\epsilon$-pseudospectra $\sigma_\epsilon(A)$ of square matrices $A \in \mathbb{C}^{N \times N}$. We give a complete characterization of the $\epsilon$-pseudospectrum of any $2 \times 2$ matrix and describe the asymptotic behavior (as $\epsilon \to 0$) of $\sigma_\epsilon(A)$ for any square matrix $A$. We also present explicit upper and lower bounds for the $\epsilon$-pseudospectra of bidiagonal matrices, as well as for finite rank operators.
Functional exploration of the IFT-A complex in intraflagellar transport and ciliogenesis

Intraflagellar transport (IFT) particles or trains are composed of IFT-A and IFT-B complexes. To assess the working mechanism of the IFT-A complex in IFT and ciliogenesis, we have analyzed ift43 mutants of Chlamydomnonas in conjunction with mutants of the other IFT-A subunits. An ift43 null mutant or a mutant with a partial deletion of the IFT43 conserved domain has no or short flagella. The mutants accumulate not only IFT-B but also IFT-Ain the short flagella, which is in contrast to an ift140 null mutant. The IFT43 conserved domain is necessary and sufficient for the function of IFT43. IFT43 directly interacts with IFT121 and loss of IFT43 results in instability of IFT-A. A construct with a partial deletion of the IFT43 conserved domain is sufficient to rescue the instability phenotype of IFT-A, but results in diminishing of IFT-A at the peri-basal body region. We have further provided evidence for the direct interactions within the IFT-A complex and shown that the integrity of IFT-A is important for its stability and cellular localization. Finally, we show that both IFT43 and IFT140 are involved in mobilizing ciliary precursors from the cytoplasmic pool during flagellar regeneration, suggesting a novel role of IFT-A in transporting ciliary components in the cytoplasm to the peri-basal body region.
Prediction and analysis of Pakistan election 2013 based on sentiment analysis

The significance of social media has already been proven in provoking transformation of public opinion for developed countries in improving democratic process of elections. On the contrary, developing countries lacking basic necessities of life possess monopolistic electoral system in which candidates are elected based on tribes, family backgrounds, or landlord influences. They extort voters to cast votes against their promises for the provision of basic needs. Similarly voters also poll votes for personal interests being unaware of party manifesto or national interest. These issues can be addressed by social media, resulting as ongoing process of improvement for presently adopted electoral procedures. People of Pakistan utilized social media to garner support and campaign for political parties in General Elections 2013. Political leaders, parties, and people of Pakistan disseminated party's agenda and advocacy of party's ideology on Twitter without much campaigning cost. To study effectiveness of social media inferred from individual's political behavior, large scale analysis, sentiment detection & tweet classification was done in order to classify, predict and forecast election results. The experimental results depicts that social media content can be used as an effective indicator for capturing political behaviors of different parties Positive, negative and neutral behavior of the party followers as well as party's campaign impact can be predicted from the analysis. The analytical findings proved to be having considerable correspondence with actual results as published by Election Commission of Pakistan.