Miracle-dz/UniFAR-FTUs huggingface dataset:
American Journal of Epidemiology Original Contribution Self-reported Experiences of Discrimination and Visceral Fat in Middle-aged African-american and Caucasian Women

The authors examined the association between self-reported experiences of discrimination and subtypes of abdominal fat (visceral, subcutaneous) in a population-based cohort of African-American and Caucasian women. Prior studies examining associations between discrimination and abdominal fat have yielded mixed results. A major limitation of this research has been the reliance on waist circumference, which may be a poor marker of visceral fat, particularly for African-American women. Participants were 402 (45% African-American, 55% Cauca-sian) middle-aged women from the Chicago, Illinois, site of the Study of Women's Health Across the Nation. Visceral and subcutaneous fat were assessed via computed tomography scans between 2002 and 2005. Linear regression models were conducted to test associations among discrimination and visceral and subcutaneous fat. After adjustment for age and race, every one-point increase on the discrimination scale was associated with a 13.03-cm 2 higher amount of visceral fat (P ¼ 0.04). This association remained significant after further adjustments for total body fat and relevant risk factors, including depressive symptoms. Discrimination was not associated with subcutaneous fat in minimally (P ¼ 0.95) or fully adjusted models. Associations did not differ by race. Findings suggest that visceral fat may be one potential pathway through which experiences of discrimination increase cardiovascular risk. Editor's note: A related article appears on page 1232, an invited commentary on the 2 articles is published on page 1240, and a response to the commentary by the authors of the first article is on page 1244. In accordance with Journal policy, the authors of the second article were asked whether they wanted to respond to the commentary, but they chose not to do so. Several lines of evidence suggest that psychosocial stressors in the form of self-reported experiences of discrimination and interpersonal mistreatment may have a deleteri-ous impact on cardiovascular health. Researchers have reported associations between experiences of discrimination and elevated blood pressure (1–4), atherosclerosis (5, 6), inflammation (7, 8), and overall mortality (9). Findings have been particularly pronounced for African Americans (1, 6) but have been observed among Caucasians as well (7, 9). The pathways underlying associations between experiences of discrimination and cardiovascular health remain poorly understood, however. The current study was designed to examine the association between experiences of discrimination and one potential pathway—visceral fat—in a cohort of African-American and Caucasian women. Visceral fat has been identified as an important risk factor for subsequent cardiovascular events, particularly among women (10, 11). Compared with other …
Radiotherapy of the Nitric Oxide Pathway : Implications for Tumor Irradiation-induced Angiogenesis through the Up-regulation Updated Version Cited Articles Citing Articles E-mail Alerts Irradiation-induced Angiogenesis through the Up-regulation of the Nitric Oxide Pathway: Implications for Tumor Rad

The combination of radiotherapy and antiangiogenic strategies has been shown to increase the tumor response in various experimental models. The rationale for this cotherapy was initially related to the expected gain in efficacy by acting on two different targets, e.g., tumor cells and endothelial cells (ECs). However, recent studies have documented more than additive effects due to apparent mutual potentiation of these approaches. In this study, we tested the hypothesis that these synergistic effects could stem from the stimulatory effects of ionizing radiations on angiogenesis, which would then need to be restrained to avoid tumor regrowth after irradiation. We found that irradiation dose-dependently induced the activation of the proangiogenic NO pathway in ECs through increases in endothelial nitric oxide synthase abundance and phosphoryl-ation. Using 2-and 3-dimensional cultures of ECs and isolated mouse tumor arterioles, we documented that the irradiation-induced enhanced production of NO accounted for EC migration and sprouting. Irradiation was also shown to stimulate the colonization of Matrigel plugs implanted in mouse by ECs, where they formed capillary-like structures in a NO-dependent manner. These findings were confirmed by documenting the NO-mediated infiltration of CD31-positive ECs after local irradiation of Lewis lung carcinoma tumor-bearing mice. Finally, we measured a consistent increase in endothelial nitric oxide synthase mRNA by real-time PCR experiments in human biopsies of head and neck squamous cell carcinoma after low-dose irradiation. In conclusion, we have demonstrated that the potentiation of the NO signaling pathway after irradiation induces profound alterations in the EC phenotype leading to tumor an-giogenesis. Moreover, our demonstration that the inhibition of NO production suppresses these provascular effects of irradiation highlights new potentials for the coordinated use of antiangiogenic strategies and radio-therapy in clinical practice.
Journal of Cardiovascular Magnetic Resonance Open Access towards Comprehensive Assessment of Mitral Regurgitation Using Cardiovascular Magnetic Resonance Background

Cardiovascular magnetic resonance (CMR) is increasingly used to assess patients with mitral regurgitation. Its advantages include quantitative determination of ventricular volumes and function and the mitral regurgitant fraction, and in ischemic mitral regurgitation, regional myocardial function and viability. In addition to these, identification of leaflet prolapse or restriction is necessary when valve repair is contemplated. We describe a systematic approach to the evaluation of mitral regurgitation using CMR which we have used in 149 patients with varying etiologies and severity of regurgitation over a 15 month period. Following standard ventricular cine acquisitions, including 2, 3 and 4 chamber long axis views and a short axis stack for biventricular function, we image movements of all parts of the mitral leaflets using a contiguous stack of oblique long axis cines aligned orthogonal to the central part of the line of coaptation. The 8–10 slices in the stack, orientated approximately parallel to a 3-chamber view, are acquired sequentially from the superior (antero-lateral) mitral commissure to the inferior (postero-medial) commissure, visualising each apposing pair of anterior and posterior leaflet scallops in turn (A1-P1, A2-P2 and A3-P3). We use balanced steady state free precession imaging at 1.5 Tesla, slice thickness 5 mm, with no inter-slice gaps. Where the para-commissural coaptation lines curve relative to the central region, two further oblique cines are acquired orthogonal to the line of coaptation adjacent to each commissure. To quantify mitral regurgitation, we use phase contrast velocity mapping to measure aortic outflow, subtracting this from the left ventricular stroke volume to calculate the mitral regurgitant volume which, when divided by the left ventricular stroke volume, gives the mitral regurgitant fraction. In patients with ischemic mitral regurgitation, we further assess regional left ventricular function and, with late gadolinium enhancement, myocardial viability. Comprehensive assessment of mitral regurgitation using CMR is feasible and enables determination of mitral regurgitation severity, associated leaflet prolapse or restriction, ventricular function and viability in a single examination and is now routinely performed at our centre. The mitral valve stack of images is particularly useful and easy to acquire. which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Differentiation of Strains of Xylella fastidiosa by a Variable Number of Tandem Repeat Analysis

ABSTRACT Short sequence repeats (SSRs) with a potential variable number of tandem repeat (VNTR) loci were identified in the genome of the citrus pathogen Xylella fastidiosa and used for typing studies. Although mono- and dinucleotide repeats were absent, we found several intermediate-length 7-, 8-, and 9-nucleotide repeats, which we examined for allelic polymorphisms using PCR. Five genuine VNTR loci were highly polymorphic within a set of 27 X. fastidiosa strains from different hosts. The highest average Nei's measure of genetic diversity (H) estimated for VNTR loci was 0.51, compared to 0.17 derived from randomly amplified polymorphic DNA (RAPD) analysis. For citrus X. fastidiosa strains, some specific VNTR loci had a Hvalue of 0.83, while the maximum value given by specific RAPD loci was 0.12. Our approach using VNTR markers provides a high-resolution tool for epidemiological, genetic, and ecological analysis of citrus-specific X. fastidiosa strains.
DisCoverage: A new paradigm for multi-robot exploration

The main aspect in multi-robot exploration is the efficient coordination of a group of robots. Inspired by previous results on the coverage problem, we propose a novel, frontier-based approach for multi-robot exploration. This approach merges the step of choosing appropriate target points with the step of planning a collision-free path. This is achieved by optimizing an objective function consisting of distance and orientation costs as well as an estimated information gain. The optimization yields motion control laws directly solving the exploration task. Using a Voronoi partition of the environment ensures, that each robot autonomously creates and optimizes the objective function to obtain a collision-free path in a distributed fashion. Simulations demonstrate the effectiveness of our approach.
Use of Endoluminal Ultrasound to Evaluate Gastrointestinal Motility

The use of high-frequency ultrasound transducers in the gastrointestinal tract (GI) has already yielded remarkable findings concerning the anatomy, physiology and pathophysiology of the GI tract and of various motility disorders. These transducers have made completely invisible portions of the GI tract (the longitudinal smooth muscle, muscles of the upper esophageal sphincter, components of the gastroesophageal junction high-pressure zone, and the muscle of the anal sphincter complex) accessible to investigation. Use of simultaneous ultrasound and manometry has allowed the exploration of the normal physiology of peristaltic contraction. The components of the high-pressure zone of the distal and proximal esophagus have been isolated and the movement of these components has been studied individually and as a group. Various esophageal motility disorders have been investigated including achalasia, scleroderma, Barrett’s esophagus and diffuse esophageal spasm. The possible etiology of the symptoms of esophageal chest pain and heartburn (sustained esophageal contractions of the longitudinal smooth muscle), have been studied. The possible underlying pathophysiology of GERD (the missing gastric clasp and sling fiber pressure profile) has been explored. Three-dimensional high-frequency ultrasound imaging has allowed the peristaltic contraction sequence to be viewed in a completely new and unique manner. The biomechanics of both esophageal contraction and the gastroesophageal junction high-pressure zone have been investigated and the mechanical advantage of esophageal shorting has been studied. The mechanism of action of standard surgical and newer endoscopic therapies for GERD has been defined. Future applications of this technology are limited only by our imagination.
CFD SIMULATION OF THERMO-AERAULIC FIELDS IN A CHANNEL WITH MULTIPLE BAFFLE PLATES

In this paper, a two-dimensional incompressible flow of a Newtonian fluid through a horizontal duct of rectangular section, where four flat rectangular baffle plates were inserted and fixed to the top and bottom walls in a periodically staggered manner, is examined and analyzed numerically using the finite volume method by means of commercial CFD software FLUENT 6.3. Researchers consider this situation as a significant issue in the field of heat exchangers, for which the fluid flow characterization, heat transfer and skin friction loss distribution, along with the existence and the extension of possible re-circulations must be determined. The aspect ratio of channel width-to-height, channel length-to-hydraulic diameter, baffle spacing-to-channel height ratio, and blockage ratio of baffle height-to-channel height are fixed at W/H = 1.321, L/D h = 5.137, Pi/H = 0.972, and h/H = 0.547, respectively. The Reynolds-Averaged Navier-Stokes Equations are the governing flow equations for the problem investigated, with the energy equation. In particular, flow and temperature fields, dimensionless axial velocity profiles, skin friction coefficients, local and average Nusselt numbers, and thermal enhancement factor were presented at constant wall temperature condition along the upper and lower channel walls. The presence of the baffle plates in the whole domain analyzed causes a much high skin-friction loss, f/f 0 = 10.829-25.412 but also provides a considerable heat transfer increase in the duct, Nu/Nu 0 = 3.623-5.008, depending on the Re values. The enhancement thermal factor for fluid flowing in the baffled channel with larger flow rate is found to be higher than that with smaller flow rate. The enhancement thermal factor augments with the rise of Reynolds number and thus, the highest Reynolds number value, Re = 32,000, provides maximum thermal performance factor, TEF = 1.783. This indicates that the introducing the flat rectangular baffle plates into the flow in a staggered arrangement can improve the heat transfer efficiency inside the channel.
Time-moving Metaphors and Ego-moving Metaphors: Which Is Better Comprehended by Taiwanese?

This is a semantic pilot study which concentrates on how people in Taiwan process the temporal metaphors, ego-moving metaphor and time-moving metaphor. Motivated by the research of Gentner, Imai, and Boroditsky (2002) in which the English native speakers comprehend ego-moving metaphors faster than time-moving metaphors, the present study attempts to reexamine whether the faster reaction to ego-moving metaphors is shared by both the Chinese native speakers and EFL learners. To achieve the goals, 25 Chinese/English bilinguals are invited to be examined via the16 Chinese and 16 English test sentences. The recordings of their accuracy on each item are served as the databases used to compare with the study of Gentner, Imai, and Boroditsky (2002). The two finding presented here are: (1) when the subjects tested in their native language, Chinese, they process ego-moving metaphors better. (2) when tested in the foreign language, English, they conceptualize time-moving metaphors much better.
Childhood trauma exposure and alcohol dependence severity in adulthood: mediation by emotional abuse severity and neuroticism.

BACKGROUND Childhood trauma has been linked with a number of negative outcomes later in life, including alcohol dependence (AD). Previous studies have suggested a mediating role for neuroticism in the relationship between childhood trauma and psychopathology. In this study, we investigate the prevalence of multiple types of childhood trauma in treatment-seeking alcohol-dependent patients, and the associations between childhood trauma and AD severity using multiple mediation analysis. METHODS The prevalence of 5 types of childhood trauma-emotional abuse, sexual abuse, physical abuse, emotional neglect, and physical neglect-was assessed in treatment-seeking alcohol-dependent patients (n = 280) and healthy controls (n = 137) using the Childhood Trauma Questionnaire. Multiple mediation analyses were used to model associations between childhood trauma measures and alcohol-related outcomes, primarily the severity of AD in the alcohol-dependent sample. RESULTS Childhood trauma was significantly more prevalent and more severe in the alcohol-dependent subjects. In addition, childhood trauma was found to influence AD severity, an effect that was mediated by neuroticism. When individual trauma types were examined, emotional abuse was found to be the primary predictor of AD severity, both directly and through the mediating effects of the impulsivity subfacet of neuroticism. Physical abuse also had a moderate direct effect on AD severity. Mediation analysis did not reveal any association between childhood trauma and Alcohol Use Disorders Identification Test score in the nondependent control sample. CONCLUSIONS Childhood trauma is highly prevalent in treatment-seeking alcoholics and may play a significant role in the development and severity of AD through an internalizing pathway involving negative affect. Our findings suggest that alcoholics with a history of childhood emotional abuse may be particularly vulnerable to severe dependence.
Clinical management of older people with non-small cell lung cancer in England

Data for 25261 patients with non-small cell lung cancer whose details were submitted to the National Lung Cancer Audit in England were analysed to assess the effect of age at diagnosis on their clinical management, after accounting for sex, stage, performance status and comorbidity. Multivariate logistic regression showed the odds of having histocytological confirmation and anticancer treatment decreased progressively with age, and was also lower in women. It is likely that these results have a multifactorial explanation, and further research into the attitudes of patients, carers and healthcare professionals, and clinical trials of treatment in older populations, are necessary.
Cascaded Segmentation-Detection Networks for Text-Based Traffic Sign Detection

In this paper, we propose a novel text-based traffic sign detection framework with two deep learning components. More precisely, we apply a fully convolutional network to segment candidate traffic sign areas providing candidate regions of interest (RoI), followed by a fast neural network to detect texts on the extracted RoI. The proposed method makes full use of the characteristics of traffic signs to improve the efficiency and accuracy of text detection. On one hand, the proposed two-stage detection method reduces the search area of text detection and removes texts outside traffic signs. On the other hand, it solves the problem of multi-scales for the text detection part to a large extent. Extensive experimental results show that the proposed method achieves the state-of-the-art results on the publicly available traffic sign data set: Traffic Guide Panel data set. In addition, we collect a data set of text-based traffic signs including Chinese and English traffic signs. Our method also performs well on this data set, which demonstrates that the proposed method is general in detecting traffic signs of different languages.
Partial neuromuscular blockade and cardiovascular responses to static exercise in man.

In human subjects sustained static contractions of the quadriceps femoris in one leg were performed with the same absolute and the same relative intensity before and after partial neuromuscular blockade with either decamethonium or tubocurarine which reduced strength to about 50% of the control value. During the contractions performed with the same absolute force, the magnitude of the cardiovascular responses (heart rate and blood pressure) was greater during neuromuscular blockade than during control contractions. During the contractions involving the same relative force the magnitude of the cardiovascular responses was almost the same with and without neuromuscular blockade. These findings were independent of the drug used. The metabolic part of the exercise pressor reflex was assessed by the application of an arterial cuff 1/2 min before cessation of exercise and for the following 3 min of rest. Although heart rate and blood pressure decreased after cessation of exercise, application of the tourniquet resulted in higher post‐exercise values and this effect was seen both with and without neuromuscular blockade. Muscle biopsies from the subjects' m. vastus lateralis were analysed for fast‐ and slow‐twitch fibre composition showing 27‐66% slow‐twitch fibres. No correlation was found between cardiovascular responses to static exercise, with or without neuromuscular blockade, and fibre type predominance. The results suggest that the involvement of fast‐ or slow‐twitch muscle fibres does not play a dominant role in the cardiovascular responses to static exercise in man. Both central command and reflex neural mechanisms are of importance, and it appears that these two control mechanisms are redundant and that neural occlusion may be operative. However, when partial neuromuscular blockade induces a disproportion between an increase in central command and a constant or decreasing muscle tension and metabolism, the larger signal arising from central command determines the magnitude of the cardiovascular responses.
Recruitment of human cyclin T1 to nuclear bodies through direct interaction with the PML protein

Human cyclin T1, the cyclin partner of Cdk9 kinase in the positive transcription elongation factor b (P‐TEFb), is an essential cellular cofactor that is recruited by the human immunodeficiency virus type 1 (HIV‐1) Tat transactivator to promote transcriptional elongation from the HIV‐1 long terminal repeat (LTR). Here we exploit fluorescence resonance energy transfer (FRET) to demonstrate that cyclin T1 physically interacts in vivo with the promyelocytic leukaemia (PML) protein within specific subnuclear compartments that are coincident with PML nuclear bodies. Deletion mutants at the C‐terminal region of cyclin T1 are negative for FRET with PML and fail to localize to nuclear bodies. Cyclin T1 and PML are also found associated outside of nuclear bodies, and both proteins are present at the chromatinized HIV‐1 LTR promoter upon Tat transactivation. Taken together these results suggest that PML proteins regulate Tat‐ mediated transcriptional activation by modulating the availability of cyclin T1 and other essential cofactors to the transcription machinery.
Superoxide Production and Expression of Nox Family Proteins in Human Atherosclerosis

Background—NAD(P)H oxidases are important sources of superoxide in the vasculature, the activity of which is associated with risk factors for human atherosclerosis. This study was designed to investigate the localization of superoxide production and the expression of the Nox family of NAD(P)H oxidase proteins (gp91phox, Nox1, and Nox4) in nonatherosclerotic and atherosclerotic human coronary arteries. Methods and Results—In coronary artery segments from explanted human hearts, we examined intracellular superoxide production with dihydroethidium. In nonatherosclerotic coronary arteries, superoxide was present homogenously throughout the intima, media, and adventitia. In atherosclerotic arteries, there was an additional intense area of superoxide in the plaque shoulder, which is rich in macrophages and &agr;-actin–positive cells. p22phox colocalized with gp91phox mainly in macrophages, whereas Nox4 was found only in nonphagocytic vascular cells. Expression of gp91phox and p22phox mRNA was associated with the severity of atherosclerosis. gp91phox correlated with the plaque macrophage content, whereas Nox4 correlated with the content of &agr;-actin–positive cells. Nox1 expression was low both in human coronary arteries and isolated vascular cells. Conclusions—Several Nox proteins, including gp91phox and Nox4, may contribute to increased intracellular oxidative stress in human coronary atherosclerosis in a cell-specific manner and thus may be involved in the genesis and progression of human coronary atherosclerotic disease.