Miracle-dz/UniFAR-FTUs huggingface dataset:
Intestinal dysmotility in inflammatory bowel disease: Mechanisms of the reduced activity of smooth muscle contraction

Inflammation suppresses intestinal motility, which secondarily induces abnormal growth of intestinal flora. Disturbance of this flora plays a role in the pathogenesis of mucosal inflammation, which in turn aggravates the intestinal dysmotility. Therefore, it is important to know the mechanism of alteration in motor function in the inflamed intestine. Recent studies have shown molecular mechanisms responsible for the motility disorder in the inflamed gut. These include an increase in the activity of myosin light-chain phosphatase and an alteration of ion channel activity in smooth muscle cells.
Vitamin A facilitates enteric nervous system precursor migration by reducing Pten accumulation

Hirschsprung disease is a serious disorder of enteric nervous system (ENS) development caused by the failure of ENS precursor migration into the distal bowel. We now demonstrate that retinoic acid (RA) is crucial for GDNF-induced ENS precursor migration, cell polarization and lamellipodia formation, and that vitamin A depletion causes distal bowel aganglionosis in serum retinol-binding-protein-deficient (Rbp4–/–) mice. Ret heterozygosity increases the incidence and severity of distal bowel aganglionosis induced by vitamin A deficiency in Rbp4–/– animals. Furthermore, RA reduces phosphatase and tensin homolog (Pten) accumulation in migrating cells, whereas Pten overexpression slows ENS precursor migration. Collectively, these data support the hypothesis that vitamin A deficiency is a non-genetic risk factor that increases Hirschsprung disease penetrance and expressivity, suggesting that some cases of Hirschsprung disease might be preventable by optimizing maternal nutrition.
Meaning in Life, Flow, and Subjective Well-Being: A perspective on Filipino High School Students

The purpose of the present study is to determine the effects of meaning in life and flow on subjective well-being among Filipino high school students. It was hypothesized in this study that meaning in life and flow contributes in explaining individuals’ subjective well-being. Four measures, namely, the Satisfaction with Life Scale (SWLS), Subjective Happiness Scale (SHS), Meaning in Life Questionnaire (MILQ) and Short (9-Item) Flow Scale were administered to 304 freshmen high school students in different schools in the Philippines. The Structural Equations Modeling (SEM) was used to test the effect of meaning in life and flow on subjective well-being. The manifest variables for meaning in life include presence of meaning and search for meaning as, flow include the dispositional flow and state flow, and subjective well-being is composed of life satisfaction and subjective happiness. Results of the study indicated that the model tested attained a good fit (χ2 = 3.96, df = 6, χ2/ df =.61, NFI=.99, RFI=.97, CFI=.99, RMSEA=.01). Only the effect of meaning in life was significant on subjective well-being.
Purification and characterization of protocatechuate 2,3-dioxygenase from Bacillus macerans: a new extradiol catecholic dioxygenase

Protocatechuate 2,3-dioxygenase (2,3-PCD) from Bacillus macerans JJ1b has been purified to homogeneity for the first time. The enzyme catalyzes proximal extradiol ring cleavage of protocatechuate (PCA) with the attendant incorporation of both atoms of oxygen from O2. The holoenzyme has a mass of 143 +/- 7 kDa as determined by ultracentrifugation and other techniques. It is composed of four apparently identical subunits with M(r)s of 35,500, each containing one iron atom. Mössbauer spectroscopy of 57Fe-enriched enzyme showed that the irons are indistinguishable and are high spin (S = 2) Fe2+ in both the uncomplexed and substrate-bound enzyme. However, the quadrupole splitting, delta EQ, and isomer shift, delta, of the Mössbauer spectrum changed from delta EQ = 2.57 mm/s and delta = 1.29 mm/s to delta EQ = 2.73 mm/s and delta = 1.19 mm/s upon PCA binding to the enzyme, showing that the iron environment is altered when substrate is present. The enzyme was also found to bind variable and substoichiometric amounts of Mn2+, but this metal could be removed without loss of activity or stability. The inherently electron paramagnetic resonance (EPR)-silent Fe2+ of the enzyme reversibly bound nitric oxide to produce an EPR-active species (g = 4.11, 3.95; S = 3/2). The specific activity of the enzyme was found to be correlated with the amount of the S = 3/2 species formed, showing that activity is dependent on Fe2+. Anaerobic addition of substrates to the enzyme-nitric oxide complex significantly altered the EPR spectrum, suggesting that substrates bind to or near the iron. The enzyme was inactivated by reagents that oxidize the Fe2+, such as H2O2 and K3FE(CN)6; full activity was restored after reduction of the iron by ascorbate. Steady-state kinetic data were found to be consistent with an ordered bi-uni mechanism in which the organic substrate must add to 2,3-PCD before O2. The enzyme has the broadest substrate range of any of the well-studied catecholic dioxygenases. All substrates have vicinal hydroxyl groups on the aromatic ring except 4-NH2-3-hydroxybenzoate. This is the first substrate lacking vicinal hydroxyl groups reported for catecholic extradiol dioxygenases. 2,3-PCD is the final member of the PCA dioxygenase family to be purified. It is compared with other members of this family as well as other catecholic dioxygenases.
Epigenetics and aging

Researchers review how random changes and our environment (for example, diet) determines our life span. Over the past decade, a growing number of studies have revealed that progressive changes to epigenetic information accompany aging in both dividing and nondividing cells. Functional studies in model organisms and humans indicate that epigenetic changes have a huge influence on the aging process. These epigenetic changes occur at various levels, including reduced bulk levels of the core histones, altered patterns of histone posttranslational modifications and DNA methylation, replacement of canonical histones with histone variants, and altered noncoding RNA expression, during both organismal aging and replicative senescence. The end result of epigenetic changes during aging is altered local accessibility to the genetic material, leading to aberrant gene expression, reactivation of transposable elements, and genomic instability. Strikingly, certain types of epigenetic information can function in a transgenerational manner to influence the life span of the offspring. Several important conclusions emerge from these studies: rather than being genetically predetermined, our life span is largely epigenetically determined; diet and other environmental influences can influence our life span by changing the epigenetic information; and inhibitors of epigenetic enzymes can influence life span of model organisms. These new findings provide better understanding of the mechanisms involved in aging. Given the reversible nature of epigenetic information, these studies highlight exciting avenues for therapeutic intervention in aging and age-associated diseases, including cancer.
Therapeutic Effect of Total Saponins from Dioscorea nipponica Makino on Gouty Arthritis Based on the NF-κB Signal Pathway: An In vitro Study

Objective: Dioscorea nipponica Makino is one of the most common used traditional Chinese drugs which are used to treat gouty arthritis (GA). Nuclear factor-κB (NF-κB) pathway plays an important role during this process. In the present study, we investigated the effects of total saponins from D. nipponica Makino (TDN) on NF-κB pathway in interleukin-1β (IL-1β) induced fibroblast-like synoviocytes (FLS). Materials and Methods: FLS were divided into three groups: Normal group, model group, which was given 10 μg/L IL-1β to induce the proliferation, and TDN group (10 μg/L IL-1β +100 μg/L TDN). 1 h, 24 h, 48 h, and 72 h after treating, immune fluorescence method was used to detect the cell location of NF-κB p65. Electrophoretic mobility shift assay was used to detect the activation of NF-κB p65. Western blot method was used to detect the protein expressions of NF-κB p65, IκBα, and p-IκBα. Results: TDN could inhibit the activation and transfer of NF-κB p65. As time went on, the expression of NF-κB p65 in the cytoplasm was decreased while it was increased in the nucleus. The expression of p-IκBα was increased, whereas the expression of IκBα was not changed. TDN could regulate these abnormal expressions. Conclusion: TDN may treat GA by regulating NF-κB signal pathway. SUMMARY TDN could inhibit the transfer of NF-κB p65. TDN could inhibit the activation of NF-κB p65. TDN could inhibit the expression of p-IκBα Abbreviations used: TDN: Total saponins from Dioscorea nipponica Makino, GA: Gouty arthritis, FLS: Fibroblast-like synoviocytes, IL-1β: Interleukin-1 beta, IF: Immune fluorescence, EMSA: Electrophoretic mobility shift assay, WB: Western blot.
Modeling of a VoIP Server based on the number of call

In this paper, we define analytically a mathematical model of a VoIP Server, or more precisely the Asterisk server from the search results of Eduardo and Pablo Montoro casilari. From these models we verified the similarity of results from the outcome of the experiment cited above. Our theme therefore focuses on using material: RAM, CPU and bandwidth of a VoIP Server with respect to the number of calls emitted by clients using the serve.
A Fractal-based CNN for Detecting Complicated Curves in AFM Images

Convolutional neural networks (CNNs) have been widely used in computer vision, including low-and middle-level vision problems such as contour detection and image reconstruction. In this paper, we propose a novel fractal-based CNN model for the problem of complicated curve detection, providing a geometric interpretation of CNN-based image model leveraging local fractal analysis. Utilizing the notion of local self-similarity, we develop a local fractal model for images. A curve detector is designed based on the model, consisting of an orientation-adaptive filtering process to enhance the local response along a certain orientation. This is followed by a post-processing step to preserve local invariance of the fractal dimension of image. We show the iterative framework of such an adaptive filtering process can be re-instantiated approximately via a CNN model, the nonlinear processing layer of which preserves fractal dimension approximately and the convolution layer achieves orientation enhancement. We demonstrate our fractal-based CNN model on the challenging task for detecting complicated curves from the texture-like images depicting microstructures of materials obtained by atomic force microscopy (AFM).
The mental health help seeking experiences of female victims of intimate partner violence

This mixed-method study examined the influence of intimate partner violence (IPV) on the mental health help seeking experience of twenty-two women who received domestic violence services at a local Women's Domestic Violence Center and Shelter. The volunteer convenience sample completed the Conflict Tactic Scale 2 Short Form (CTS2S), Patient Health Questionnaire (PHQ)-9, Post-traumatic Stress Disorder Checklist-Civilian (PCL-C), and the Social Support from Others (SFO) scale along with a qualitative interview based on the Health Belief Model (HBM) assessing their experiences of mental health service acquisition outside of the shelter. Findings revealed high rates of psychological abuse (95%), physical assault and injury (82%), and sexual coercion (64%) by their intimate partner in past year. Reported PTSD was 62% and depression 55%. Identified themes related to the women's perceived need for mental health care, barriers to care, and benefits of care. Perceived need related to feelings of fear, anxiety, isolation, and concern for children. Barriers included difficulty trusting and forming a therapeutic alliance with mental health providers and finding appropriate mental health response to IPV. Perceived benefits of mental health treatment related to receiving validation and improved self-regard. Mixed-method analyses revealed a significant relationship for perceived need with both depression and PTSD. Higher perceived barriers significantly related to PTSD and depression. Lower perceived benefit significantly related to PTSD but not to depression. Social support negatively correlated with depression, PTSD and IPV. The majority of the women cited shelter staff and residents as primary providers of support. Implications include the need for increased understanding of IPV among mental health providers and increased flexibility of services for IPV victims. Further research is suggested on the mental health implications of psychological abuse and trauma associated with IPV and increasing effective provider and treatment strategies to engage IPV victims in mental health treatment.
On the Energy-Efficiency of Byte-Addressable Non-Volatile Memory

Non-volatile memory (NVM) technology holds promise to replace SRAM and DRAM at various levels of the memory hierarchy. The interest in NVM is motivated by the difficulty faced in scaling DRAM beyond 22 nm and, long-term, lower cost per bit. While offering higher density and negligible static power (leakage and refresh), NVM suffers increased latency and energy per memory access. This paper develops energy and performance models of memory systems and applies them to understand the energy-efficiency of replacing or complementing DRAM with NVM. Our analysis focusses on the application of NVM in main memory. We demonstrate that NVM such as STT-RAM and RRAM is energy-efficient for memory sizes commonly employed in servers and high-end workstations, but PCM is not. Furthermore, the model is well suited to quickly evaluate the impact of changes to the model parameters, which may be achieved through optimization of the memory architecture, and to determine the key parameters that impact system-level energy and performance.
Explorer Unsupervised Semantic Role Induction with Graph Partitioning

In this paper we present a method for unsupervised semantic role induction which we formalize as a graph partitioning problem. Argument instances of a verb are represented as vertices in a graph whose edge weights quantify their role-semantic similarity. Graph partitioning is realized with an algorithm that iteratively assigns vertices to clusters based on the cluster assignments of neighboring vertices. Our method is algorithmically and conceptually simple, especially with respect to how problem-specific knowledge is incorporated into the model. Experimental results on the CoNLL 2008 benchmark dataset demonstrate that our model is competitive with other unsupervised approaches in terms of F1 whilst attaining significantly higher cluster purity.
Chronic inflammation and mortality in haemodialysis: effect of different renal replacement therapies. Results from the RISCAVID study.

BACKGROUND The 'RISchio CArdiovascolare nei pazienti afferenti all' Area Vasta In Dialisi' (RISCAVID) study is an observational and prospective trial including the whole chronic haemodialysis (HD) population in the northwest part of Tuscany (1.235 million people). The aim of the study was to elucidate the relevance of traditional and non-traditional risk factors of mortality and morbidity in HD patients as well as the impact of different HD modalities. METHODS A total of 757 HD patients (mean age 66 +/- 14 years, mean dialytic age 70 +/- 76 months, diabetes 19%) were prospectively followed up for 30 months and all-cause mortality, cardiovascular (CV) mortality and non-fatal CV events (acute myocardial infarction and stroke) were registered. At the time of the enrolment, demographic, clinical and laboratory data of the whole population were entered into a centralized database. Serum albumin, high-sensitive C-reactive protein (CRP), interleukin-6 (IL-6) and interleukin-8 (IL-8) were centrally determined at the start of the study. Patients were stratified into three groups according to the HD modality: standard bicarbonate HD (BHD) (n = 424), haemodiafiltration (HDF) with sterile bags (n = 204) and online HDF (n = 129). The Cox proportional hazards regression assessed adjusted differences in CV morbidity and mortality risk; a multivariate analysis was also performed. RESULTS All-cause and CV mortality was 12.9%/year and 5.9%/year, respectively. Patients with combined high levels of CRP and pro-inflammatory cytokines showed an increased risk for CV (RR 1.9, P < 0.001) and all-cause mortality (RR 2.57, P < 0.001). Multivariate analysis adjusted for comorbidity and demographic showed CRP as the most powerful mortality predictor (P < 0.001) followed by IL-6. The Cox proportional hazards regression assessed that online HDF and HDF patients had a significantly increased adjusted cumulative survival than BHD (P < 0.01). CONCLUSIONS Data at 30 months from this study showed the synergic effect of CRP and pro-inflammatory cytokines as the strong predictors of all-cause and CV mortality. HDF was associated with an improved cumulative survival independent of the dialysis dose.
Personality Development In Adolescence : A Cross National and Lifespan Perspective

The formation of identity in adolescence is the most central concept in psychological and sociological studies of young people. Most theories to date assume that adolescents share the same conditions under which their identities are formed. Personality Development in Adolescence is a collection of work by leading researchers that considers different contexts affecting personality and identity development. Three main contexts are considered: cultural, family and life-span development. Of central importance to developmental psychologists, this collection will also be valuable to social workers, teachers, nurses and all those whose work involves young people.
Coding for noisy quadratic-Gaussian Wyner-Ziv problem : A successive quantization approach

Wyner-Ziv coding (WZC) is a compression technique which uses decoder side-information to help reconstruction. We present a new coding structure using two-stage successive quantization with two codebooks to solve the Wyner-Ziv problem in the quadratic Gaussian case. The optimal Wyner-Ziv bound is proved to be achievable by random coding analysis. Compared to the existing nested-lattice based design approaches, the two component codes in our construction can be designed independently, which simplifies the code design significantly. Moreover, besides the original noiseless setting where the source is directly observed by the encoder, our coding also suits for the noisy WZC problem where the source is observed via a noisy memoryless channel.
An Investigation of Inhibitory Control in Bilingual Aphasia

Title of dissertation: AN INVESTIGATION OF INHIBITORY CONTROL IN BILINGUAL APHASIA Monica Sampson, Doctor of Philosophy, 2015 Dissertation directed by: Yasmeen Faroqi-Shah, Ph.D. Department of Hearing and Speech Sciences Speaking involves selecting words and syntactic structures from among numerous competing options. It has been suggested that constant practice in using inhibitory control (IC) to limit within and cross-language competition may be associated with better lexicalsemantic IC in proficient bilingual speakers relative to monolingual speakers. This advantage is also theorized to generalize to IC advantages in non-linguistic tasks (bilingual advantage hypothesis; BAH; Bialystok, 2001). However, conflicting evidence with regard to bilingual IC advantages abound, and the nature of relationship between linguistic and domain-general inhibitory control abilities is poorly understood. Since IC is proposed to be critical for lexical retrieval, it is important to understand the nature of IC engaged in individuals with lexical retrieval deficits (aphasia). Bilingual speakers with aphasia provide an ideal platform to examine the relationship between language processing and IC because there are seemingly contradictory effects at play: while bilingualism may render an IC advantage, acquired brain injury may be associated with less efficient IC. These contrasting effects allow one to tease apart the effects of bilingualism on IC, the domain generality of the bilingual IC advantage, and relationship between bilingualism, IC and lexical selection. It is important to examine these effects relative to matched monolingual controls to understand (i) if there is a bilingual advantage in lexically based IC and, (ii) the domain generality of any bilingual IC advantage. To address these aims, IC engaged in (i) lexical retrieval (semantically blocked cyclic naming task), (ii) linguistic processing (Stroop task), and (iii) non-linguistic processing (flanker task) was compared in ten each of bilingual (Tamil-English) and monolingual (English) neurologically healthy speakers and participants with aphasia. Results from neurologically healthy participants revealed a bilingual advantage in the blocked cyclic naming task (lexical IC) but no advantages in the non-lexical Stroop and flanker tasks. Results from participants with aphasia revealed no support for the proposed bilingual advantages in all three experiments. Furthermore, there was no significant association between inhibitory control measures in the three experimental tasks for all participants. Contrary to the predictions of the BAH, the collective results of this study indicate that there is insufficient evidence for the role of bilingualism in modulating nonlexical IC advantages. This lack of consistent support for BAH questions the influence of bilingual experience in modulating non-linguistic inhibitory control. These findings also reveal that the relationship between inhibitory control and lexical retrieval is not influenced by language background (monolingual versus bilingual) in persons with
LDF-CLOCK: The Least-Dirty-First CLOCK Replacement Policy for PCM-based Swap Devices

Phase-change memory (PCM) is a promising technology that is anticipated to be used in the memory hierarchy of future computer systems. However, its access time is relatively slower than DRAM and it has limited endurance cycle. Due to this reason, PCM is being considered as a high-speed storage medium (like swap device) or long-latency memory. In this paper, we adopt PCM as a virtual memory swap device and present a new page replacement policy that considers the characteristics of PCM. Specifically, we aim to reduce the write traffic to PCM by considering the dirtiness of pages when making a replacement decision. The proposed replacement policy tracks the dirtiness of a page at the granularity of a sub-page and replaces the least dirty page among pages not recently used. Experimental results with various workloads show that the proposed policy reduces the amount of data written to PCM by 22.9% on average and up to 73.7% compared to CLOCK. It also extends the lifespan of PCM by 49.0% and reduces the energy consumption of PCM by 3.0% on average.