Miracle-dz/UniFAR-FTUs huggingface dataset:
Predictors of antipsychotic treatment response in patients with first episode schizophrenia, schizoaffective, and schizophreniform disorders

Background Duration of untreated psychosis (DUP) may contribute to the observed heterogeneity of the treatment response in first-episode schizophrenia. Aims To examine the relationship of DUP and premorbid function with clinical outcomes following up to 2 years of antipsychotic treatment. Method For a subsample (n = 191) of subjects participating in a clinical trial, DUP and premorbid function were prospectively compared with clinical response to olanzapine or haloperidol. Results Shorter DUP and good premorbid function each independently are associated with better clinical response, including improvement in overall psychopathology and negative symptoms. Premorbid function also is associated with positive symptom, social and vocational outcomes. Conclusions Earlier antipsychotic treatment is associated with better outcomes in first-episode schizophrenia. Poor premorbid function could indicate an illness subtype less likely to respond to antipsychotic treatment regardless of when it is instituted.
Fate of 2,2,2-trichloroacetaldehyde (chloral hydrate) produced during trichloroethylene oxidation by methanotrophs

Four different methanotrophs expressing soluble methane monooxygenase produced 2,2,2-trichloroacetaldehyde, or chloral hydrate, a controlled substance, during the oxidation of trichloroethylene. Chloral hydrate concentrations decreased in these cultures between 1 h and 24 h of incubation. Chloral hydrate was shown to be biologically transformed to trichloroethanol and trichloroacetic acid by Methylosinus trichosporium OB3b. At elevated pH and temperature, chloral hydrate readily decomposed and chloroform and formic acid were detected as products.
THE DISTANT OUTER GAS ARM BETWEEN l = 35° AND l = 45°

The Galactic plane has been mapped from l = 34. °75 to 45. °25 and b = −5. °25 to 5. °25 in the CO (J = 1–0) emission with the 13.7 m telescope of the Purple Mountain Observatory. The unbiased survey covers a large area of 110 square degrees sampled every 30″ with a velocity resolution of . In this paper, we present the result of an unbiased CO survey of this longitude and latitude range in the velocity range from −60 to . Over 500 molecular clouds (MCs) are picked out from the 12CO (J = 1–0) emission, and 131 of these MCs are associated with 13CO emission. The distant MCs, which lie beyond the solar circle and are mostly concentrated in the Galactic plane, trace the large-scale molecular gas structure over 10 degrees of Galactic azimuth. We find that the distribution of the distant MCs can be well fitted by a Gaussian function with a full width at half maximum (FWHM) of 0. °7 with the Galactic latitude. We suggest that the CO emission of the segment is from the Outer Arm. The physical mid-plane traced by the Outer Arm seems to be slightly displaced from the IAU-defined plane on a large scale, which could be explained by the warped plane at large Galactocentric distances of ≳10 kpc and the apparent tilted mid-plane to the projected IAU-defined plane caused by the Sun’s z-height above the disk for distances near and within the Solar circle. After removing the effect of the warp and tilted structure, the scale height of the MCs in the Outer Arm is about 0. °6 or 160 pc at a heliocentric distance of 15 kpc. If the inner plane of our Galaxy is flat, we can derive an upper limit of the Sun’s offset of ∼17.1 pc above the physical mid-plane of the Milky Way. We also discuss the correlations between the physical parameters of the distant MCs, which is quite consistent with the result of other studies of this parameter.
Utilizing community pharmacy dispensing records to disclose errors in hospital admission drug charts.

OBJECTIVE To identify and resolve discrepancies in admission medication histories, utilizing community pharmacy dispensing data, in newly hospitalized patients and investigate the relationship between unresolved discrepancies and length of hospital stay. METHODS Eligible patients (2 or more chronic conditions, 3 or more chronic medications and aged over 50 years) were randomized to the intervention or control group. Within 24 h of admission, the patient's nominated community pharmacy was contacted, a 6-month dispensing history obtained, patient was interviewed and a current medication list compiled. This was compared with the hospital drug chart. Discrepancies for the intervention group were discussed with the attending doctor. Subsequent resolution of discrepancies was assessed for all patients. RESULTS 487 patients were included (203 intervention, 284 control). Approximately 66% of all patients had at least 1 discrepancy between their reconciled list of medications and their initial drug chart, with no significant difference between the groups. Significantly more intervention patients had at least 1 discrepancy resolved in the first 48 h than control patients (intervention 78.1%; control 36.5%; p < 0.0001). A weak correlation was found between the number of discrepancies not acted on and length of hospital stay (Spearman Rho = 0.1, n = 487, p < 0.01). CONCLUSION Errors in admission medication histories are common and potentially lead to an increased length of stay. The provision of a 6-month community pharmacy dispensing history at the time of hospital admission is an important addition to ensure an accurate medication chart is compiled.
CysView: protein classification based on cysteine pairing patterns

CysView is a web-based application tool that identifies and classifies proteins according to their disulfide connectivity patterns. It accepts a dataset of annotated protein sequences in various formats and returns a graphical representation of cysteine pairing patterns. CysView displays cysteine patterns for those records in the data with disulfide annotations. It allows the viewing of records grouped by connectivity patterns. CysView's utility as an analysis tool was demonstrated by the rapid and correct classification of scorpion toxin entries from GenPept on the basis of their disulfide pairing patterns. It has proved useful for rapid detection of irrelevant and partial records, or those with incomplete annotations. CysView can be used to support distant homology between proteins. CysView is publicly available at http://research.i2r. a-star.edu. sg/CysView/.
The Effects of Hope, Rumination, Resilience, and Unit Support on Post-traumatic Stress Disorder Symptom Severity in Veterans

The current study investigated potential protective resources: hope, rumination, resilience and unit support as they related to PTSD symptom severity among service members who deployed to Iraq or Afghanistan and experienced combat (N = 191). We also investigated each variable for possible interactions with combat exposure. Correlational analyses and hierarchical linear regression were used to analyze the data. Hope, resilience and unit support were all negatively correlated with PTSD symptom severity and combat exposure. Deliberate rumination and intrusive rumination were positively correlated with PTSD symptom severity. In the regression, significant predictors were rank, combat exposure, resilience and intrusive rumination, with enlisted rank, higher combat exposure, and higher intrusive rumination predicting higher levels of PTSD symptom severity and resilience predicting lower levels. Resilience moderated the relationship between combat exposure and PTSD symptom severity, such that participants who had higher levels of resilience had lower levels of PTSD symptom severity at all levels of combat exposure. These findings suggest the importance of increasing resilience in combat veterans, specifically those of enlisted rank and veterans exposed to higher levels of combat. Findings also suggest that teaching veterans how to control or minimize intrusive rumination may help lower the risk that a veteran will develop PTSD.
Pelvic Exenteration for Recurrent Gynecologic Malignancy: A Study of 28 Consecutive Patients at a Single Institution

Objective The aim of this study was to assess the outcomes of patients undergoing pelvic exenteration (PE) for recurrent gynecologic malignancy. Methods A retrospective review using all medical records of 28 consecutive patients who underwent PE between January 2002 and December 2011 at a single institution was conducted. Complications were graded according to Clavien-Dindo. Overall survival (OS) and disease-free survival (DFS) were estimated by the method of Kaplan-Meier. Results Pelvic exenteration was performed for recurrent cancer in all patients. Distribution of primaries was as follows: cervix (n = 10), vagina (n = 5), ovary (n = 5), uterus (n = 4), tube (n = 2), Bartholin gland (n = 1), and vulva (n = 1). In all but 1 case, PE was performed with curative intent. Pelvic exenteration was total (n = 11), anterior (n = 2), or posterior (n = 15). Reconstructive procedures included urinary tract (n = 13), gastrointestinal tract (n = 26), pelvic floor (n = 6), and vagina (n = 5). There was no postoperative mortality within 30 days. All patients developed 1 or several early complications of various grades, and 22 patients (79%) developed late complications. Twelve patients (43%) underwent reoperation because of complications to PE, and 2 patients died within follow-up as a consequence of their PE. A complete tumor resection (R0) was obtained in 23 patients (82%). With a median follow-up of 27 months (range, 2–110 months), the 5-year OS and DFS rates were 70% and 41%, respectively. R0 resection was associated with increased OS (P < 0.001) and DFS (P = 0.015). Conclusions Pelvic exenteration for recurrent gynecologic malignancies can be associated with long-term survival in selected patients. However, postoperative complications are common and can be lethal.
Signal Peptidase and Oligosaccharyltransferase Interact in a Sequential and Dependent Manner within the Endoplasmic Reticulum*

We demonstrate that the signal peptides of prepro-α-factor and preinvertase must be cleaved before Asn-X-Ser/Thr acceptor tripeptides located near the signal peptides of these precursors can be efficiently glycosylated within the endoplasmic reticulum of the yeast Saccharomyces cerevisiae. The data support a model whereby the interaction of a signal peptide with the membrane prevents an acceptor tripeptide juxtaposed to the signal peptide from accessing the oligosaccharyltransferase active site until the signal peptide is cleaved.
The Role of Gender on Perceptions of Stalking and Harassment Behaviour within Same and Cross-Sex Relationships: Evidence from University and Law Enforcement Samples

Researchers investigating perceptions of stalking have enhanced understanding of the role of gender (i.e., perceived social roles based on sex) on subjective appraisals of harassment behaviour following the dissolution of a romantic relationship. According to data collected from student and community samples, a man harassing a woman (M-W) elicits greater recommendations for police intervention, as well as a tendency to anticipate more harm, than when the same behaviour is perpetrated by a woman against a man (W-M; Cass, 2008; Finnegan & Fritz, 2012; Phillips et al., 2004; Sheridan & Scott, 2010). Although cases of stalking often come to the attention of law enforcement, no research to date to the author’s knowledge has been conducted with police officers. By manipulating a real stalking (i.e., criminal harassment) case, study 1 examined the role of actor sex (M-W, W-M) on perceptions of stalking in a sample of local police officers. Findings were consistent with previous research. Officers who read the M-W case anticipated more physical, emotional, psychological, and economic harm than officers who read the W-M case. Research has also focused almost exclusively on cross-sex stalking. Study 2 extended previous research by examining perceptions of harassment scenarios using four different actor sex permutations (M-W, W-M, M-M, and W-W) in a sample of university students. Male and female participants anticipated less physical and nonphysical harm for W-M compared to M-W, M-M, and W-W harassment. The findings have implications for research on the relation between sex and perceptions of gender, and may be used to develop intervention programs aimed at educating law enforcement, social support workers, and community agencies to ensure appropriate protection and treatment of individuals harassed by same-sex or cross-sex former partners. GENDER AND PERCEPTION v
Brain mapping : the systems

A.W. Toga, An Introduction to Maps and Atlases of the Brain. M.E. Raichle, A Brief History of Human Functional Brain Mapping. L.W. Swanson, A History of Neuroanatomical Maps. P. Fox, Functional Maps. J.C. Mazziotta, A Probabalistic Approach for Mapping the Human Brain. L. Porrino and P.S. Goldman-Rakic, Cortex. M. -F. Chesselet, Subcortical Structures. J.D. Schmahmann, Cerebellum and Brainstem. J. Watson, The Human Visual System. H. -J. Freund, Somatosensory System. S.T. Grafton, The Human Motor System. R.R. Zatorre, The Human Auditory System. R.R. Zatorre, Olfactory and Gustatory Systems. A. Damasio, Language. M. Iacaboni, Attention and Sensorimotor Integration: Mapping the Embodied Mind. E. Halgren, The Human Memory System. H.S. Mayberg, Emotion and Mood. A. -C. Nobre and M. -M. Mesulam, Cognition. S.M. Kosslyn, Neural Systems Activated During Visual Mental Imagery: A Review and Meta-Analyses. S.E. Fraser, Development. J.-C. Baron, Human Aging. S.E. Petersen, Human Learning. F. Chollet, Plasticity of the Adult Human Brain.
Independent Control Scheme for Nonredundant Two-Leg Fault-Tolerant Back-to-Back Converter-Fed Induction Motor Drives

This paper presents an investigation on a nonredundant topology for two-leg fault at a back-to-back converter-fed induction motor drives. In the case of faults occurring in any two inverter legs, the six-leg back-to-back converter can be changed to a four-leg back-to-back converter by employing one motor phase connected to the rectifier leg and another phase connected to the dc-link capacitor mid-point for fault-tolerant operation. The four-leg back-to-back converter is very attractive for the merit of not requiring additional power switches for fault-tolerant. However, as the shared-leg connection between inverter and rectifier, the rectifier and the motor drive are deeply coupled. A novel scheme-based model-predictive control is presented to achieve independent control of the grid and motor currents. The voltage limitation for independent control of the rectifier and motor drive is analyzed, and the dc-link voltage utilization is improved by capacitor voltage suppression. With the proposed scheme, the output speed range of the converter is degraded, but other performances, such as output torque capability, unity power factor, and the dynamic response, are maintained after faults occur. Finally, the control concept is verified by a TMS320F28335 DSP-based prototype.
Assessing Organizational Communication: Strategic Communication Audits

Assessing Organizational Communication: Strategic Communication Audits. CaI W. Downs and Allyson D. Adrian. New York: Guilford Press, 2004. 292 pp. $40 pbk. At first glance, Assessing Organizational Communication: Strategic Communication Audits looks like a text for a business school class. The book jacket touts the importance of building "comparative knowledge about organizational problems" and notes the book is best for classes that focus on "field methods, diagnostic processes, and training, and consulting in organizational communication. " The lead author, CaI W. Downs, is considered one of the "founding fathers" of the discipline of organizational communication. According to his biography, Downs has conducted training programs for global companies including OPEC. His now out-of-print 1988 textbook, Communication Audits, has reached classic status, and, according to early reviews, this new edition is much needed and well received. His coauthor, Allyson D. Adrian, is internationally known for her work presenting U.S. intellectual culture. But what does this book hold for the journalism and mass communication educator? Plenty. For the professor of public relations, advertising, or integrated marketing communication, this jewel of a textbook can add new insight into-and examples of-the deeper evaluation process mandated by today's business culture. The authors do this in clear, understandable language with straightforward instructions and samples. The book is also an affordable companion to any course textbook. The authors say the purpose of the book is to "explain different means of analysis, from which the reader is free to choose what will work best in a given situation. " This is the biggest selling point the book has to offer. This book covers everything from rationale examination to questionnaire development to focus group interviews to the importance of the final report. The book also offers a close examination of four major international survey methodologies. Each example is clearly marked, thoroughly discussed, and ready for adaptation and implementation. It's an assessment toolbox from cover to cover. Take, for example, chapter 2, titled "Initiating and Planning an Assessment. " This is a chapter about a communication audit, a valuable tool in business today. For the public relations student, knowledge of, or participation in, the process of a communication audit could be a valuable experience. It's a teachable moment examined in even the most basic public relations textbooks, and it's a process of which every public relations student should be cognizant. …
The Relationship between the Antitumor Effect of the IL-12 Gene Therapy and the Expression of Th1 Cytokines in an HPV16-Positive Murine Tumor Model

Objective. The goal of the present study was to investigate the effect of IL-12 expressed in plasmid on the Th1 cytokine profile in an experimental HPV16-positive murine tumor model and the association with the IL-12's antitumor effect. Methods. Mice were injected with BMK-16/myc cells to establish HPV16-positive tumor and then pNGVL3-mIL-12 plasmid; pcDNA3 plasmid or PBS was injected directly into tumor site. The antitumor effect of the treatment was evaluated and the cytokines expression profile in each tumor tissue was analyzed. Results. Treatment with pNGVL3-mIL-12 plasmid had a significant antitumor effect, and a Th2-Th3-type cytokines prolife was detected in the murine tumor model with expression of the cytokines IL-10, IL-4, and TGF-β1. However, after the tumor was treated with three intratumoral injections of plasmid containing IL-12 cDNA, it showed a cytokine profile associated with Th1 with expression of IL-2, IL-12, and IFN-γ cytokines and reduced expression of IL-10, IL-4, and TGF-β1. Conclusions. The treatment with the IL-12 gene in the experimental HPV16-positive tumor model promoted the activation of the cellular immune response via expression of a Th1-type cytokine profile and was associated with the inhibition of tumor growth. Thus, IL-12 treatment represents a novel approach for gene therapy against cervical cancer.
The Tuning Project for Medicine – learning outcomes for undergraduate medical education in Europe

The Tuning Project is an initiative funded by the European Commission to develop learning outcomes/competences for degree programmes in Europe and to promote harmonisation in the Higher Education sector. It is closely linked to the Bologna Declaration and subsequent developments. Under the auspices of the MEDINE Thematic Network for Medical Education in Europe, the Tuning (Medicine) Task Force has generated a draft set of learning outcomes for primary medical degree qualifications in Europe. These take account of previous work on learning outcomes in medicine, have been generated through an iterative process of expert review and development, and have been the subject of a Europe-wide internet-based opinion survey and subsequent analysis. They have been approved by the MEDINE Network and validated (subject to some additional analysis) by an Expert Panel of the European Commission.
Increased Visual Behavior in Low Vision Children

TEN PAIRS OF BLIND CHILDREN AGED SIX TO 13 YEARS WHO HAD SOME VISION WERE MATCHED BY PRETEST SCORES ON A TEST Of VISUAL DISCRIMINATION. A CRITERION GROUP, DESIGNATED THE PRINT COMPARISON GROUP, HAD SLIGHLY HIGHER RECORDED DISTANCE ACUITIES AND USED VISION AS THE PRIMARY MEANS OF LEARNING. PAIRS OF EXPERIMENTAL SUBJECTS DAILY RECEIVED 45 MINUTES OF TRAINING DESIGNED TO INCREASE FUNCTIONAL USE OF REMAINING VISION. SPECIFIC LESSON PLANS FOLLOWED THE FOUR SEQUENTIAL STAGES FOR DISCRIMINATION AND RECOGNITION OF VISUAL STIMULI -GEOMETRIC FORMS IN SOLID BLACK AND IN OUTLINE SHAPES, SINGLE OBJECT FORMS IN SOLID BLACK AND IN OUTLINE SHAPES, GROUPED OBJECTS IN COLOR AND IN OUTLINE WITH FULL INNER DETAILS, AND LETTER AND WORD SYMBOLS. MATERIALS GRADUALLY DECREASED IN SIZE. AT COMPLETION OF TRAINING SESSIONS SUBJECTS WERE AGAIN TESTED WITH THE TEST OF VISUAL DISCRIMINATION. ANALYSIS OF RESULTS SHOWED A STATISTICALLY SIGNIFICANT DIFFERENCE IN (1) TEST SCORES OF EXPERIMENTAL GROUP CHILDREN, (2) THE DIFFERENCE IN THE EXPERIMENTAL AND CONTROL GROUPS' MEAN GAINS AND (3) MEAN GAIN BETWEEN EXPERIMENTAL AND PRINT COMPARISON GROUPS. NEAR VISION ACUITIES INCREASED IN SEVEN OF THE TEN SUBJECTS, BUT MEAN INCREASE WAS NOT STATISTICALLY SIGNIFICANT, NOR WAS THERE A SIGNIFICANT DIFFERENCE BETWEEN THE TWO GROUPS. THE VISUAL DISCRIMINATION TEST YIELDED A TEST -RETEST STABILITY COEFFICIENT OF . 98. APPENDIXES INCLUDE THE VISUAL DISRIMINATION TEST, THE 44 LESSON PLANS AND MATERIALS USED, RATING SHEET FOR DAILY PROGRESS, SUMMARIES OF EXPERIMENTAL GROUP SUBJECTS, AND RELEVANT CHARTS. REFERENCE LIST CITES 76 ITEMS. THIS DOCUMENT WAS PUBLISHED BY THE AMERICAN FOUNDATION FOR THE BLIND, 15 WEST 16TH STREET, NEW YORK, NEW YORK 10011,
Formulation and Multiobjective Design Optimization of Wound-Field Flux Switching Machines for Wind Energy Drives

In this study, constrained multiobjective design optimization (MDO) of wound-field flux switching machines (WF-FSMs) for wind energy drives is undertaken in two-dimensional (2-D) static finite-element analyses (FEA), facilitated by simple analytic formulations. The MDO implementation is fully discussed, whereby the simulations for two different problem formulations produce Pareto optimal solutions, which enable important design considerations. Two optimal design candidates, each from the MDO problems investigated, are isolated and compared. The comparison shows that minimizing manufacturing costs places too much pressure on the electromagnetic performance of the WF-FSM, whereas optimizing the generator performance may improve the efficiency and cost of the drivetrain solid state converters (SSCs), with little compromise to the generator costs. In the end, 3-D transient FEA results are provided for validation.
A management development model

Purpose – The purpose of this study is to investigate the nature of organizational commitment and the impact on executive's motivational level in providing job satisfaction within a learning organization.Design/methodology/approach – A management development model examines the relationship between the measurable constructs. The model explores the relationship between the executive's motivation level and their outcome with job satisfaction and organizational learning.Findings – The results indicate there is a goodness‐of‐fit for the research model. The path coefficients explained a significant amount of variation along with the identification that organizational commitment is a significant attribute in the management development model.Research limitations/implications – Limitations include the self‐report methodology that measures perceptual data with a series of questionnaire items.Originality/value – The study examines executive's perceptions and the significance of organizational commitment. Management .