Miracle-dz/UniFAR-FTUs huggingface dataset:
Dasatinib induces fast and deep responses in newly diagnosed chronic myeloid leukaemia patients in chronic phase: clinical results from a randomised phase-2 study (NordCML006)

We randomised 46 newly diagnosed patients with chronic myeloid leukaemia (median age 56) to receive dasatinib 100 mg QD or imatinib 400 mg QD and report outcome as an intention‐to‐treat analysis with 36 months follow‐up. Early cytogenetic and molecular responses were superior in the dasatinib group, with a tendency that imatinib patients caught up with time. For instance, MR3.0 was reached at 3 months in 36% vs. 8% (P = 0.02), at 12 months in 81% vs. 46% (P = 0.02) and at 18 months in 73% vs. 65% (n.s.) of the patients in the two groups. In contrast, MR4.5 was consistently superior in the dasatinib group at all time points from 6 months onwards, reaching 61% vs. 21% (P < 0.05) at 36 months. Sixty‐four vs. 71% of the patients in the dasatinib and imatinib arms, respectively, remained on assigned drug. Dasatinib dose was frequently reduced, but with maintained excellent effect. One imatinib patient progressed to blastic phase, but no CML‐related deaths occurred. In conclusion, our data compare favourably with those of the dasatinib registration study, DASISION. The fast and deep molecular responses induced by dasatinib compared with imatinib may be exploited to increase the proportion of patients who can achieve a treatment‐free remission after treatment discontinuation.
Affiliation and Control During Marital Disagreement, History of Divorce, and Asymptomatic Coronary Artery Calcification in Older Couples

Objective: To examine behavioral observations of affiliation (ie, warmth versus hostility) and control (ie, dominance versus submissiveness) and prior divorce as predictors of coronary artery calcification (CAC) in older couples. In some but not all studies, marital disruption and low marital quality have been shown to confer risk of coronary artery disease (CAD). Inconsistencies might reflect limitations of self-reports of marital quality compared with behavioral observations. Also, aspects of marital quality related to CAD might differ for men and women. Methods: Couples underwent computed tomography scans for CAC and marital assessments, including observations of laboratory-based disagreement. Participants were 154 couples (mean age, 63.5 years; mean length of marriage, 36.4 years) free of prior diagnosis of CAD. Results: Controlling traditional risk factors, we found behavioral measures of affiliation (low warmth) accounted for 6.2% of variance in CAC for women, p < . 01, but not for men. Controlling behavior (dominance) accounted for 6.0% of variance in CAC for men, p < . 02, but not for women. Behavioral measures were related to self-reports of marital quality, but the latter were unrelated to CAC. History of divorce predicted CAC for men and women. Conclusions: History of divorce and behavioral-but not self-report-measures of marital quality were related to CAD, such that low warmth and high dominance conferred risk for women and men, respectively. Prior research might underestimate the role of marital quality in CAD by relying on global self-reports of this risk factor.CAD = coronary artery disease; CAC = coronary artery calcification; CHD = coronary heart disease; IPC = interpersonal circumplex; MAP = mean arterial blood pressure; SASB = structural analysis of social behavior.
The added value of implementing the Planet Game scenario with Collage and Gridcole

This paper discusses the suitability and the added value of Collage and Gridcole when contrasted with other solutions participating in the ICALT 2006 workshop titled "Comparing educational modelling languages on a case study. " In this workshop each proposed solution was challenged to implement a Computer-Supported Collaborative Learning situation (CSCL) posed by the workshop's organizers. Collage is a pattern-based authoring tool for the creation of CSCL scripts compliant with IMS Learning Design (IMS LD). These IMS LD scripts can be enacted by the Gridcole tailorable CSCL system. The analysis presented in the paper is organized as a case study which considers the data recorded in the workshop discussion as well the information reported in the workshop contributions. The results of this analysis show how Collage and Gridcole succeed in implementing the scenario and also point out some significant advantages in terms of design reusability and generality, user-friendliness, and enactment flexibility. Editors: Laurence Vignollet (Universite de Savoie, France) Interactive elements: Collage authoring tool is published in SourceForge and can be also downloaded from http://gsic.tel. uva.es/collage
Associations between human aldosterone synthase (CYP11B2) gene polymorphisms and left ventricular size, mass, and function.

BACKGROUND Aldosterone has direct and indirect effects on the heart, and genetic variations in aldosterone synthesis could therefore influence cardiac structure and function. Such variations might be associated with polymorphisms in the gene encoding aldosterone synthase (CYP11B2), the enzyme catalyzing the last steps of aldosterone biosynthesis. METHODS AND RESULTS A Finnish population sample of 84 persons (44 women) aged 36 to 37 years was studied by M-mode and Doppler echocardiography to assess left ventricular size, mass, and function. Subjects were genotyped through the use of the polymerase chain reaction for two diallelic polymorphisms in CYP11B2: one in the transcriptional regulatory region (promoter) and the other in the second intron. In multiple regression analyses, the CYP11B2 promoter genotype predicted statistically significant variations in left ventricular end-diastolic diameter (beta=.40, P<.0001), end-systolic diameter (beta=.33, P=.0009), and mass (beta=.17, P=.023). These effects were independent of potentially confounding factors, including sex, body size, blood pressure, physical activity, smoking, and ethanol consumption. Genotype groups also differed in a measure of left ventricular diastolic function, the heart rate-adjusted atrial filling fraction (P=.018). Increased dietary salt, which is known to predict increased left ventricular mass, had this effect only in association with certain CYP11B2 genotypes (P<.001). CONCLUSIONS Genetic variations in or near the aldosterone synthase (CYP11B2) gene strongly affect left ventricular size and mass in young adults free of clinical heart disease. These polymorphisms may also influence the response of the left ventricle to increases in dietary salt.
Analysis of the Expression of Anthocyanin Pathway Genes in Developing Vitis vinifera L. cv Shiraz Grape Berries and the Implications for Pathway Regulation

Anthocyanin synthesis in Vitis vinifera L. cv Shiraz grape berries began 10 weeks postflowering and continued throughout berry ripening. Expression of seven genes of the anthocyanin biosynthetic pathway (phenylalanine ammonia lyase [PAL], chalcone synthase [CHS], chalcone isomerase [CHI], flavanone-3-hydroxylase [F3H], dihydroflavonol 4-reductase [DFR], leucoanthocyanidin dioxygen-ase [LDOX], and UDP glucose-flavonoid 3-o-glucosyl transferase [UFGT]) was determined. In flowers and grape berry skins, expression of all of the genes, except UFGT, was detected up to 4 weeks postflowering, followed by a reduction in this expression 6 to 8 weeks postflowering. Expression of CHS, CHI, F3H, DFR, LDOX, and UFGT then increased 10 weeks postflowering, coinciding with the onset of anthocyanin synthesis. In grape berry flesh, no PAL or UFGT expression was detected at any stage of development, but CHS, CHI, F3H, DFR, and LDOX were expressed up to 4 weeks postflowering. These results indicate that the onset of anthocyanin synthesis in ripening grape berry skins coincides with a coordinated increase in expression of a number of genes in the anthocyanin biosynthetic pathway, suggesting the involvement of regulatory genes. UFGT is regulated independently of the other genes, suggesting that in grapes the major control point in this pathway is later than that observed in maize, petunia, and snapdragon.
Nystagmus Does Not Limit Reading Ability in Albinism

Purpose Subjects with albinism usually suffer from nystagmus and reduced visual acuity, which may impair reading performance. The contribution of nystagmus to decreased reading ability is not known. Low vision and nystagmus may have an additive effect. We aimed to address this question by motion compensation of the nystagmus in affected subjects and by simulating nystagmus in healthy controls. Methods Reading speed and eye movements were assessed in 9 subjects with nystagmus associated with albinism and in 12 healthy controls. We compared the reading ability with steady word presentation and with words presented on a gaze contingent display where words move in parallel to the nystagmus and thus correct for the nystagmus. As the control, healthy subjects were asked to read words and texts in steady reading conditions as well as text passages that moved in a pattern similar to nystagmus. Results Correcting nystagmus with a gaze contingent display neither improved nor reduced the reading speed for single words. Subjects with nystagmus and healthy participants achieved comparable reading speed when reading steady texts. However, movement of text in healthy controls caused a significantly reduced reading speed and more regressive saccades. Conclusions Our results argue against nystagmus as the rate limiting factor for reading speed when words were presented in high enough magnification and support the notion that other sensory visual impairments associated with albinism (for example reduced visual acuity) might be the primary causes for reading impairment.
Low Dose Computed Tomography for 3D Planning of Total Hip Arthroplasty: Evaluation of Radiation Exposure and Image Quality

Objective The aim of the study was to compare radiation exposure and image quality between dedicated computed tomography (CT) protocols for preoperative total hip arthroplasty (THA) planning. Methods Three protocols with automated tube current modulation using 64-slice (n = 177) and 128-slice CT scanners without (n = 129) and with automated tube voltage preselection (n = 84) were compared. Results All 390 CTs were of sufficient quality for THA planning. Mean DLP was 235.0 mGy*cm (effective dose 2.8 mSv). Lowest radiation exposure (2.5 mSv) was seen with automated voltage preselection and the algorithm's selection was 100 kV (90.5% of patients) and 120 kV. Lowest image noise was seen in the highest dose group (3.1 mSv, 128-slice CT fixed tube voltage). A significant difference in cortical bone radiodensity was seen between 100 kV and 120 kV (P < 0.0001). Conclusions Preoperative pelvic CT for THA planning is possible with very low radiation dose and reliable quality. Automated voltage preselection further decreases the effective dose by 18.2%.
Dermal Dendrocytes FXIIIa+ Are Essential Antigen-Presenting Cells in Indeterminate Leprosy

Abstract:Indeterminate leprosy (IL) is the early phase of Hansen disease and reword (APCs). Langerhans cells and dermal dendrocytes FXIIIa positive (DDFXIIIa) are the major APCs in the skin and can be identified by the expression of CD1a and FXIIIa, respectively, by immunohistochemical techniques. Plasmacytoid dendritic cells (PDCs) are another type of dermal dendrocytes with a questionable antigen-presenting function and can be highlighted by anti-CD123 expression. To our knowledge, there are no studies evaluating DDFXIIIa and PDC in IL. The purpose was to investigate the involvement of these cells in the pathogenesis of IL. The authors performed a retrospective study on 18 cases of IL (10 confirmed and 8 suspected) to investigate expression of FXIIIa, CD1a, and CD123. The results were compared with normal skin (for CD1a and FXIIIa only). A higher amount of FXIIIa-positive cells (P < 0.05) in confirmed and suspected IL cases was noted when comparing with normal skin. However, CD1a showed no quantitative differences in the epidermis of IL lesions when comparing with normal skin and CD123 expression was negligible. Based on these findings, the authors postulate that Langerhans cells and PDCs do not have a major role in IL and that DDFXIIIa may be the main APCs in IL. Further study is required to establish this.
Loading-dependent elemental composition of α-pinene SOA particles

Abstract. The chemical composition of secondary organic aerosol (SOA) particles, formed by the dark ozonolysis of α-pinene, was characterized by a high-resolution time-of-flight aerosol mass spectrometer. The experiments were conducted using a continuous-flow chamber, allowing the particle mass loading and chemical composition to be maintained for several days. The organic portion of the particle mass loading was varied from 0.5 to >140 μg/m3 by adjusting the concentration of reacted α-pinene from 0.9 to 91.1 ppbv. The mass spectra of the organic material changed with loading. For loadings below 5 μg/m3 the unit-mass-resolution m/z 44 (CO2+) signal intensity exceeded that of m/z 43 (predominantly C2H3O+), suggesting more oxygenated organic material at lower loadings. The composition varied more for lower loadings (0.5 to 15 μg/m3) compared to higher loadings (15 to >140 μg/m3). The high-resolution mass spectra showed that from >140 to 0.5 μg/m3 the mass percentage of fragments containing carbon and oxygen (CxHyOz+) monotonically increased from 48% to 54%. Correspondingly, the mass percentage of fragments representing CxHy+ decreased from 52% to 46%, and the atomic oxygen-to-carbon ratio increased from 0.29 to 0.45. The atomic ratios were accurately parameterized by a four-product basis set of decadal volatility (viz. 0.1, 1.0, 10, 100 μg/m3) employing products having empirical formulas of C1H1.32O0. 48, C1H1.36O0. 39, C1H1.57O0. 24, and C1H1.76O0.14. These findings suggest considerable caution is warranted in the extrapolation of laboratory results that were obtained under conditions of relatively high loading (i.e., >15 μg/m3) to modeling applications relevant to the atmosphere, for which loadings of 0.1 to 20 μg/m3 are typical. For the lowest loadings, the particle mass spectra resembled observations reported in the literature for some atmospheric particles.
Isolation and characterization of Saccharomyces cerevisiae mutants deficient in S-adenosylmethionine decarboxylase, spermidine, and spermine

Four mutants were isolated from Saccharomyces cerevisiae that are deficient in S-adenosylmethionine decarboxylase (spe2). All four mutants are chromosomal and fall into a single complementation group tightly linked to arg1. Since one of the mutants contained a temperature-sensitive activity, this complementation group defines the structural gene. Mutants totally lacking enzymic activity did not contain spermidine or spermine and had a greatly increased doubling time when grown in the absence of these two polyamines. Addition of 10(-6) M spermidine or 10(-5) M spermine, but not putrescine or cadaverine, restored the doubling time to that of the wild type. Diploids formed from a cross of two mutants completely deficient in spermidine and spermine were unable to sporulate in the absence of added spermidine or spermine. We obtained evidence that arg1 was not located on any of the 17 known chromosomes, and therefore we postulate that arg1 and spe2 are located on a new 18th chromosome.
NELF and GAGA Factor Are Linked to Promoter-Proximal Pausing at Many Genes in Drosophila

ABSTRACT Recent analyses of RNA polymerase II (Pol II) revealed that Pol II is concentrated at the promoters of many active and inactive genes. NELF causes Pol II to pause in the promoter-proximal region of the hsp70 gene in Drosophila melanogaster. In this study, genome-wide location analysis (chromatin immunoprecipitation-microarray chip [ChIP-chip] analysis) revealed that NELF is concentrated at the 5′ ends of 2,111 genes in Drosophila cells. Permanganate genomic footprinting was used to determine if paused Pol II colocalized with NELF. Forty-six of 56 genes with NELF were found to have paused Pol II. Pol II pauses 30 to 50 nucleotides downstream from transcription start sites. Analysis of DNA sequences in the vicinity of paused Pol II identified a conserved DNA sequence that probably associates with TFIID but detected no evidence of RNA secondary structures or other conserved sequences that might directly control elongation. ChIP-chip experiments indicate that GAGA factor associates with 39% of the genes that have NELF. Surprisingly, NELF associates with almost one-half of the most highly expressed genes, indicating that NELF is not necessarily a repressor of gene expression. NELF-associated pausing of Pol II might be an obligatory but sometimes transient checkpoint during the transcription cycle.
Plan representation and execution in multi-actor scenarios by means of social commitments

We present an approach to plan representation in multi-actor scenarios that is suitable for flexible replanning and plan revision purposes in dynamic non-deterministic multi-actor environments. The key idea of the presented approach is in representation of the distributed hierarchical plan by social commitments, as a theoretically studied formalism representing mutual relations among intentions of collaborating agents. The article presents a formal model of a recursive form of commitments and discusses how it can be deployed to a selected hierarchical planning scenario. The decommitment rules definition and their influence on the plan execution robustness and stability is also presented. The approach was verified and evaluated in a simulated environment. The experimental validation confirms the performance, stability, and robustness of the system in complex scenarios.
Spatial relationships between tree species and gap characteristics in broad-leaved deciduous woodland

Questions: 1. What are the spatial patterns of all trees, individual tree species, trees within particular height classes, all gaps and gaps with specific properties across the study site in broad-leaved deciduous forest at a range of scales? 2. Are patterns of the above features spatially associated? 3. Are these patterns indicative of gap creation mechanisms and phases of regeneration? Location: Frame Wood, New Forest, UK. Methods: Ripley’s K-function analysis was applied to spatial information derived from airborne remotely sensed imagery to characterize the patterns of trees and gaps and to test for spatial interactions between these patterns. The patterns of trees and gaps with specific physical and spatial properties were analysed. Results: The pattern of all tree species combined was random for most scales; Quercus robur followed the same random pattern, while Fagus sylvatica and Betula pendula were clustered over most spatial scales. Large gaps (> 250 m 2 ) and larger trees (> 17.5 m) were randomly distributed, while smaller gaps and smaller trees were clustered. Significant spatial relationships were demonstrated between the patterns of different tree species and between trees within different size classes, as well as between the patterns of trees and gaps with specific properties. Conclusions: Small gap patterns and field evidence indicated that progressive gap enlargement is the most likely creation mechanism for large gaps (> 250 m2). Clustered patterns of younger individuals were indicative of patches of past regeneration. As a complement to field-based data, data derived from remotely sensed imagery provides spatially comprehensive information with which to further investigate woodland stand/community processes and gap dynamics.
Optimal Selective Harmonic Mitigation Technique on Variable DC Link Cascaded H-Bridge Converter to Meet Power Quality Standards

In this paper, power quality standards such as IEC 61000-3-6, IEC 61000-2-12, EN 50160, and CIGRE WG 36-05 are fulfilled for single- and three-phase medium-voltage applications using selective harmonic mitigation-pulsewidth modulation in a cascaded H-bridge (CHB) converter. Furthermore, the ER G5/4 power quality standard, which has the strictest grid codes at the medium-voltage level, will also be met in the whole range of the modulation indices. In order to achieve this goal, a symmetrical CHB with variable dc links are employed, while the converter has a low number of switching transitions. In other words, all of the dc link voltages have the same voltage, which is dependent on the modulation index. Finally, in order to validate the effectiveness and the applicability of the proposed method, it is verified by simulations and experiments for a seven-level CHB converter.
Self-triggered control for multi-agent systems with quantized communication or sensing

The consensus problem for multi-agent systems with quantized communication or sensing is considered. Centralized and distributed self-triggered rules are proposed to reduce the overall need of communication and system updates. It is proved that these self-triggered rules realize consensus exponentially if the network topologies have a spanning tree and the quantization function is uniform. Numerical simulations are provided to show the effectiveness of the theoretical results.
Exploiting ADLs to specify architectural styles induced by middleware infrastructures

Architecture definition languages (ADLs) enable the formalization of the architecture of software systems and the execution of preliminary analyses on them. These analyses aim at supporting the identification and solution of design problems in the early stages of software development. We have used ADLs to describe middleware-induced architectural styles. These styles describe the assumptions and constraints that middleware infrastructures impose on the architecture of systems. Our work originates from the belief that the explicit representation of these styles at the architectural level can guide designers in the definition of an architecture compliant with a pre-selected middleware infrastructure, or, conversely can support designers in the identification of the most suitable middleware infrastructure for a specific architecture. In this paper we provide an evaluation of ADLs as to their suitability for defining middleware-induced architectural styles. We identify new requirements for ADLs, and we highlight the importance of existing capabilities. Although our experimentation starts from an attempt to solve a specific problem, the results we have obtained provide general lessons about ADLs, learned from defining the architecture of existing, complex, distributed, running systems.
Electrospinning of laser dye Rhodamine B-doped poly(methyl methacrylate) nanofibers

The electrospinning of rhodamine B (RhB)-doped poly(methyl methacrylate) (PMMA) is presented as a promising technique for processing photoluminescent nanofibers. Nanofibers with concentrations of RhB in PMMA between 0.05 and 2.0 wt. % were studied. The FTIR spectrum, fiber morphology, thermal properties and optical properties of the nanofibers were investigated. Smooth, bead-free and nonporous nanofibers were obtained. Differential scanning calorimetry (DSC) results revealed that the glass transi- tion temperature of the PMMA (Tg) increased with the increasing of RhB content up to 0.5 wt. % and thereafter decreased. The laser induced fluores- cence (LIF) technique was used to study the fluorescence properties of the nanofibers. The maximum fluorescence emission was observed at a concen- tration of RhB of 0.2 wt. %.