Miracle-dz/UniFAR-FTUs huggingface dataset:
Empirical Modelling in Regional Science: Towards a Global Time‒Space‒Structural Analysis

1 Introduction and Outline. - Part I: Internal Migration and the Labor Market. - 2 Panel VAR for Internal Migration Modelling. - 3 Testing the Neoclassical Migration Model. - 4 Space-Time Dependence in Migration Flows. - Part II: Trade and FDI Activity. - 5 Trade-FDI Linkages. - 6 Estimating Gravity Models: To IV or not IV? - 7 Cointegration in German Regional Output-Trade-FDI. - Part III: Growth, Factor and Final Demand. - 8 Dynamic Simultaneous Equations with Panel Data. - 9 Effects of Capital Investment Grants on Regional Growth. - 10 Dynamic Consumption Models for German States.
A piecewise linear model for trade sign inference

We use transaction level data for twelve stocks with large market capitalization on the Australian Stock Exchange to develop an empirical model for trade sign (trade initiator) inference. The new model is a piecewise linear parameterization of the model proposed recently in Ref. [1]. The space of the predictor variables is partitioned into six regions. Signs of individual trades within the regions are inferred according to simple and interpretable rules. Across the 12 stocks the new model achieves an average out-of-sample classification accuracy of 74.38% (SD=4.25%), which is 2.98% above the corresponding accuracy reported in Ref. [1]. Two of the model's regions, together accounting for 16.79% of the total number of daily trades, have each an average classification accuracy exceeding 91.50%. The results indicate a strong dependence between the predictor variables and the trade sign, and provide evidence for an endogenous component in the order flow. An interpretation of the trade sign classification accuracy within the model's regions offers new insights into a relationship between two regularities observed in the markets with a limit order book, competition for order execution and transaction cost minimization.
Distribution of nitric oxide synthase immunoreactivity in the mouse brain

Nitric oxide (NO) is a gaseous intercellular messenger with a wide range of neural functions. NO is synthesized by activation of different isoforms of nitric oxide synthases (NOS). At present NOS immunoreactivity has been described in mouse brain in restricted and definite areas and no detailed mapping studies have yet been reported for NOS immunoreactivity. We have studied the distribution of neuronal NOS‐containing neurons in the brain of three months male mice, using a specific commercial polyclonal antibody against the neuronal isoform of nitric oxide synthase (nNOS). Neuronal cell bodies exhibiting nNOS immunoreactivity were found in several distinct nuclei throughout the brain. The neurons that were positively stained exhibited different intensities of reaction. In some brain areas (i.e., cortex, striatum, tegmental nuclei) neurons were intensely stained in a Golgi‐like fashion. In other regions, immunoreactive cells are moderately stained (i.e., magnocellular nucleus of the posterior commissure, amygdaloid nucleus, interpeduncular nucleus, lateral periaqueductal gray) or weakly stained (i.e., vascular organ of the lamina terminalis, hippocampus, inferior colliculus, reticular nucleus). In the mouse, the NO‐producing system appears well developed and widely diffused. In particular, nNOS immunoreactive neurons seem chiefly present in several sensory pathways like all the nuclei of the olfactory system, as well as in many regions of the lymbic system. These data suggest a widespread role for the NO system in the mouse nervous system. Microsc. Res. Tech. 68:13–35, 2005. © 2005 Wiley‐Liss, Inc.
The Impact of Sovereign Shocks

This paper studies the dynamic propagation mechanisms of systemic risk shocks within and across macrosystems of governments and financial institutions. We propose a novel approach to identify relevant systemic shocks and to classify them into sovereign or banking categories. We find that sovereign shocks have a significant and persistent impact on the probability of a collective banking default. We also explore channels through which these shocks propagate and identify how sovereign fiscal fragility and banking exposure are relevant mechanisms of shock transmission. This paper was accepted by Gustavo Manso, finance.
Australian and European Trade Union Policies on Teamwork in the Car Industry

Many recent studies on teamwork in the car industry have examined the issues of autonomy, teamleaders, members, lean production, JIT, etc. However, only a few studies have examined policies of trade unions on teamwork and none have compared them with the shopfloor practice of teamwork. This paper is designed to close this research gap by analysing teamwork policies of the British TGWU, the German IGM and the Australian AMWU and relating it to the practice in three General Motors plants in England (Vauxhall), Germany (Opel) and Australia’s Holden plant. The analytical framework for the international comparison is Walton, Cutcher-Gershenfeld & McKersie's concept of ‘strategic negotiations’. The paper concludes that trade unions have developed similar policies on teamwork independent from each other and that most local union branches were able to translate policies made by their national leadership into shopfloor practices.
An Examination of Oregon Writing Project Teachers: A Qualitative Study of Professional Development Experiences

approved: ___________________________________________________________________ Kenneth J. Winograd This qualitative study examined the influence of the 2011 Oregon Writing Project (OWP) Summer Institute (SI) on the professional development of six teachers in the following ways: 1. The development of case descriptions of teachers’ personal and professional backgrounds relevant to their teaching of writing. 2. An examination of the effects of the Summer Institute on participants’ selfreported teaching practices, attitudes, and beliefs about the teaching of writing. 3. An examination of participants’ perceptions of aspects of the SI program that they deemed ‘influential’ in their professional development. Data was collected from Summer Institute application materials, written coursework, and follow-up interviews. Using inductive reasoning, systematic analysis of the data resulted in the following findings: 1. Teachers reported a neglect of writing education in their teacher preparation programs, as well as in the professional development programs offered by K-12 schools. 2. Participants tended to report change in their professional and personal practices, attitudes, and beliefs related to writing following the Summer Institute. 3. Participants unanimously identified the characteristics of time and a safe learning environment as significant in their professional development experience. The study suggests the need for more comprehensive inclusion of writing instructional methods in preservice and professional development programs. The study also reinforces pre-existing research that supports professional development models that are designed to be teacher and context-centered within a collaborative community. The present research highlights the need to consider factors of time and participant feelings of “safety” when designing professional development programs. Finally, the study maintains that effective professional development may offer the important teacher learning and confidence needed in K-12 schools ©Copyright by Angela D. Obery March 20, 2012 All Rights Reserved An Examination of Oregon Writing Project Teachers: A Qualitative Study of Professional Development Experiences
Proposal on Millimeter-Wave Channel Modeling for 5G Cellular System

This paper presents 28 GHz wideband propagation channel characteristics for millimeter wave (mmWave) urban cellular communication systems. The mmWave spectrum is considered as a key-enabling feature of 5G cellular communication systems to provide an enormous capacity increment; however, mmWave channel models are lacking today. The paper compares measurements conducted with a spherical scanning 28 GHz channel sounder system in the urban street-canyon environments of Daejeon, Korea and NYU campus, Manhattan, with ray-tracing simulations made for the same areas. Since such scanning measurements are very costly and time-intensive, only a relatively small number of channel samples can be obtained. The measurements are thus used to quantify the accuracy of a ray-tracer; the ray-tracer is subsequently used to obtain a large number of channel samples to fill gaps in the measurements. A set of mmWave radio propagation parameters is presented based on both the measurement results and ray-tracing, and the corresponding channel models following the 3GPP spatial channel model (SCM) methodology are also described.
Protein and Vesicle Trafficking , Cytoskeleton Actin disruption inhibits endosomal traffic of P-glycoprotein-EGFP and resistance to daunorubicin accumulation

Fu D, Roufogalis BD. Actin disruption inhibits endosomal traffic of P-glycoprotein-EGFP and resistance to daunorubicin accumulation. Am J Physiol Cell Physiol 292: C1543–C1552, 2007. First published November 22, 2006; doi:10.1152/ajpcell.00068. 2006. —Intracellular traffic of human P-glycoprotein (P-gp), a membrane transporter responsible for multidrug resistance in cancer chemotherapy, was investigated using a P-gp and enhanced green fluorescent fusion protein (P-gp-EGFP) in human breast cancer MCF-7 cells. The stably expressed P-gp-EGFP from a clonal cell population was functional as a drug efflux pump, as demonstrated by the inhibition of daunorubicin accumulation and the conferring of resistance of the cells to colchicine and daunorubicin. Colocalization experiments demonstrated that a small fraction of the total P-gp-EGFP expressed was localized intracellularly and was present in early endosome and lysosome compartments. P-gpEGFP traffic was shown to occur via early endosome transport to the plasma membrane. Subsequent movement of P-gp-EGFP away from the plasma membrane occurred by endocytosis to the early endosome and lysosome. The component of the cytoskeleton responsible for P-gpEGFP traffic was demonstrated to be actin rather than microtubules. In functional studies it was shown that in parallel with the interruption of the traffic of P-gp-EGFP, cellular accumulation of the P-gp substrate daunorubicin was increased after cells were treated with actin inhibitors, and cell proliferation was inhibited to a greater extent than in the presence of daunorubicin alone. The actin dependence of P-gp traffic and the parallel changes in cytotoxic drug accumulation demonstrated in this study delineates the pathways of P-gp traffic and may provide a new approach to overcoming multidrug resistance in cancer chemotherapy.
MODELLING OF CLIMBING FILM EVAPORATORS

The system to be modelled is that of a climbing film evaporator, as shown in Figure 1. Juice is fed to the preheater, where it is heated to the required feed temperature. The hot juice is then fed to the bottom of the evaporator tubes. For the purposes of modelling, the cane sugar juice fed to the evaporator is assumed to be a three-component mixture, consisting of water, sucrose and non-sucrose dissolved solids. It is further assumed that the following quantities are known under any given set of evaporator operating conditions, and can be assigned numerical values (Figure 1):
Lung Epithelial Injury by B. Anthracis Lethal Toxin Is Caused by MKK-Dependent Loss of Cytoskeletal Integrity

Bacillus anthracis lethal toxin (LT) is a key virulence factor of anthrax and contributes significantly to the in vivo pathology. The enzymatically active component is a Zn2+-dependent metalloprotease that cleaves most isoforms of mitogen-activated protein kinase kinases (MKKs). Using ex vivo differentiated human lung epithelium we report that LT destroys lung epithelial barrier function and wound healing responses by immobilizing the actin and microtubule network. Long-term exposure to the toxin generated a unique cellular phenotype characterized by increased actin filament assembly, microtubule stabilization, and changes in junction complexes and focal adhesions. LT-exposed cells displayed randomly oriented, highly dynamic protrusions, polarization defects and impaired cell migration. Reconstitution of MAPK pathways revealed that this LT-induced phenotype was primarily dependent on the coordinated loss of MKK1 and MKK2 signaling. Thus, MKKs control fundamental aspects of cytoskeletal dynamics and cell motility. Even though LT disabled repair mechanisms, agents such as keratinocyte growth factor or dexamethasone improved epithelial barrier integrity by reducing cell death. These results suggest that co-administration of anti-cytotoxic drugs may be of benefit when treating inhalational anthrax.
Sablefish after the individual fishing quota program: an international economic market model

Sablefish (Anoplopomafimbria) are distributed from Baja California to western Japan. Alaska is the world’s principal supplier of sablefish with the majority of commercial landings occurring in the Gulf of Alaska and the Aleutian Islands. This demersal, long-lived fish is harvested in one of Alaska’s highest valued commercial fisheries, primarily with fixed gear. The total value of the sablefish fishery is comparable to that of the Pacific halibut fishery, which is managed under the similar programs such as the federal Individual Fishing Quota (IFQ) program and various state programs. Although sablefish came to be managed under IFQs at the same time as halibut, the outcomes of IFQ implementation in this fishery have not received as much as attention as in the halibut fishery. Even twenty years after IFQ implementation, there is little published research on the impacts of IFQs on prices and revenues for sablefish. In this thesis project, I have described the various sablefish fisheries within Alaska and the international market conditions. A simultaneous equation market model for sablefish is developed to examine linkages between harvests, prices and revenues. The model is then used to examine the Alaska exvessel price and revenue effects that result from changes in landings, changes resulting from the implementation of the IFQs and changes to the Japanese economy.
Increased expression of macrophage migration inhibitory factor during progression to hypopharyngeal squamous cell carcinoma.

BACKGROUND/AIM To examine the presence of macrophage migration inhibitory factor (MIF) quantitatively in relation to neoplastic progression of hypopharyngeal squamous cell carcinoma (HSCC). MATERIALS AND METHODS The presence of MIF was analysed by quantitative immunohistochemistry in sections of 81 HSCCs, and compared to 15 specimens of tumour-free epithelia (TF_E), 29 low-grade dysplasias (Low_D) and 25 high-grade dysplasias (High_D). In parallel, MIF expression was studied using Western blotting on a series of 19 fresh biopsies. RESULTS A significant increase in MIF staining intensity (mean optical density) was observed in carcinoma samples compared to TF_E (p<10(-6)), Low_D (p=0.0006) or High_D (p=0.0006). Immunohistochemical MIF positivity was significantly higher in HSCCs than in TF_E (p=0.00001) or Low_D (p=0.001). The percentage of MIF-immunopositive cells (labelling index) significantly decreased in parallel with an apparent loss of histological differentiation (p=0.003). CONCLUSION This study identified the presence of MIF as a parameter that positively correlates with neoplastic progression of HSCC and cell differentiation status.
CLERGY WOMEN OF THE UNITED METHODIST CHURCH: EXPERIENCES AND PERCEPTIONS OF DISPARITIES AMONG WOMEN OF THE KENTUCKY ANNUAL CONFERENCE

OF DISSERTATION Tammy Leigh Reedy-Strother The Graduate School University of Kentucky 2011 CLERGY WOMEN OF THE UNITED METHODIST CHURCH: EXPERIENCES AND PERCEPTIONS OF DISPARITIES AMONG WOMEN OF THE KENTUCKY ANNUAL CONFERENCE ABSTRACT OF DISSERTATIONOF DISSERTATION A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the College of Arts and Sciences at the University of Kentucky By Tammy Leigh Reedy-Strother Lexington, Kentucky Co-Directors: Dr. Dwight B. Billings, Professor of Sociology and Dr. James G. Hougland, Jr., Professor of Sociology Lexington, Kentucky 2011 Copyright © Tammy Leigh Reedy-Strother 2011 ABSTRACT OF DISSERTATIONOF DISSERTATION CLERGY WOMEN OF THE UNITED METHODIST CHURCH: EXPERIENCES AND PERCEPTIONS OF DISPARITIES AMONG WOMEN OF THE KENTUCKY ANNUAL CONFERENCE Women in the United Methodist Church (UMC) were officially granted full clerical rights over 50 years ago, and the church’s official stance is that women and men are to enjoy fully equal rights throughout all aspects of life and society, religious and otherwise. Despite these policies, however, women’s and men’s opportunities and experiences in professional ministry in the church remain far from equal. Women continue to be underrepresented in the leadership of the UMC, especially in more prestigious appointments and positions, and face challenges to their work, leadership, and authority throughout their ministries. In fact, national statistics from the UMC show that as of 2010, only 24.6% of the clerical leaders are women. In the Kentucky Annual Conference (KAC), the focus of the present study, women are even more sparsely represented, constituting only 13.56% of the leadership as of 2010 appointments, with few serving at larger churches and only one currently serving as a district superintendent; only four have ever served in that role in the Conference’s history. Using qualitative, semi-structured interviews, I collected data from 36 of the 118 clergy women of the 2010 Conference, including women serving in all types of positions in the Conference as well as all current and former district superintendents and many of the earliest pioneers in the KAC. The goal of this study is to understand from the perspectives of these clergy women their paths into and through ministry, the support and resistance that play such key roles in their lives and work, how their families affect and are affected by their work, and the symbols and symbolic actions that they use to claim and demonstrate the authority they have been given and to navigate some of the obstacles in their paths. In order to provide a theoretical framework for this study, I used primarily social constructionism and standpoint theory and related methods.
Value-relevance of foreign-exchange and interest-rate derivatives disclosure: The case of Malaysian firms

Purpose - This paper aims to examine the state of risk management practices among Malaysian listed firms and evaluates the value-relevance of the notional amount of foreign-exchange and interest-rate derivatives (FCDs) used by listed firms over the period 2003-2007. Design/methodology/approach - Application of linear regression framework. Findings - It is found that a few Malaysian firms hedge market risks. Firms in the plantation, industrial product, trading services, and consumer products manufacturing sectors are the main users of the FCDs in Malaysia. There is a significant positive correlation between total earnings and the use of derivatives. The findings seem to suggest that although disclosed notional amount of the derivatives have value-relevance but its contribution to a firm's valuation is very minimal in Malaysia compared to other countries. Practical implications - The findings imply that those investors who have investment in those firms who use derivatives to hedge against foreign currency and interest risks benefit, albeit marginally. At present, most of the Malaysian firms are either cautious or unsure about the use of derivative instruments. There is a need to inform managers about usefulness of the derivatives and market risk reporting that would contribute to greater financial transparency. Originality/value - The author believes that this is the first study to provide survey findings on the use of derivatives instruments and their value-relevance in Malaysia.
A role of mitochondrial complex II defects in genetic models of Huntington's disease expressing N-terminal fragments of mutant huntingtin

Huntington's disease (HD) is a neurodegenerative disorder caused by an abnormal expansion of a CAG repeat encoding a polyglutamine tract in the huntingtin (Htt) protein. The mutation leads to neuronal death through mechanisms which are still unknown. One hypothesis is that mitochondrial defects may play a key role. In support of this, the activity of mitochondrial complex II (C-II) is preferentially reduced in the striatum of HD patients. Here, we studied C-II expression in different genetic models of HD expressing N-terminal fragments of mutant Htt (mHtt). Western blot analysis showed that the expression of the 30 kDa Iron–Sulfur (Ip) subunit of C-II was significantly reduced in the striatum of the R6/1 transgenic mice, while the levels of the FAD containing catalytic 70 kDa subunit (Fp) were not significantly changed. Blue native gel analysis showed that the assembly of C-II in mitochondria was altered early in N171-82Q transgenic mice. Early loco-regional reduction in C-II activity and Ip protein expression was also demonstrated in a rat model of HD using intrastriatal injection of lentiviral vectors encoding mHtt. Infection of the rat striatum with a lentiviral vector coding the C-II Ip or Fp subunits induced a significant overexpression of these proteins that led to significant neuroprotection of striatal neurons against mHtt neurotoxicity. These results obtained in vivo support the hypothesis that structural and functional alterations of C-II induced by mHtt may play a critical role in the degeneration of striatal neurons in HD and that mitochondrial-targeted therapies may be useful in its treatment.
Pengaruh Implementasi Good Corporate Governance terhadap Permodalan dan Kinerja Perbankan Di Indonesia: Manajemen Risiko Sebagai Variabel Intervening

Regulation of Bank Indonesia No. 8/4/PBI/2006 as amended by regulation No. 8/14/2006 about implementation of corporate governance become be a proof why corporate governance important in the banking sector. The purpose of this study was to determine the influence of corporate governance on risk management, bank capital, and bank performance in Indonesia. Implementation on corporate governance is measured by a composit score of corporate governance which is the result of bank self assessment. Risk management is measured by Non Performing Loans (NPL). Bank capital is measured by Capital Adequacy Ratio (CAR) and bank performance is measured by Return On Equity (ROE). The result showed that corporate governance affect risk management, corporate governance and risk management does not affect bank capital, and corporate governance do not affect bank performance, but risk management affect bank performance. Thus the risk management can be an intervening variable between corporate governance and bank performance.