Miracle-dz/UniFAR-FTUs huggingface dataset:
Do ants need to be old and experienced to teach?

SUMMARY Learning is widespread in invertebrates. However, whether social insects improve their recruitment skills with experience is only beginning to be investigated. Tandem running is a one-to-one form of recruitment used by certain species of ant. It is a remarkable communication system that meets widely accepted criteria for teaching in non-human animals. Here, we determined experimentally to what extent participation in, and efficient execution of, tandem running depends on either the age or the experience of worker ants. To investigate these issues, we constructed colonies of the ant Temnothorax albipennis with different compositions of inexperienced and experienced workers from different age cohorts and then examined which ants participated in tandem runs when they emigrated. Our results show that the ability to participate actively in recruitment by tandem running is present in all worker age groups but the propensity to participate varies with experience rather than age per se. Experienced individuals were more likely to engage in tandem runs, either as leaders or as followers, than young inexperienced individuals, and older experienced ants were more likely to lead tandems than older inexperienced ants. Young inexperienced ants led faster, more rapidly dispersing and less accurately orientated tandem runs than the older experienced ants. Our study suggests that experience (rather than age per se) coupled to stimulus threshold responses might interact to promote a division of labour so that a suitable number of workers actively participate in tandem runs.
Relocation of Aurora B from centromeres to the central spindle at the metaphase to anaphase transition requires MKlp2

Mitotic kinases of the Polo and Aurora families are key regulators of chromosome segregation and cytokinesis. Here, we have investigated the role of MKlp1 and MKlp2, two vertebrate mitotic kinesins essential for cytokinesis, in the spatial regulation of the Aurora B kinase. Previously, we have demonstrated that MKlp2 recruits Polo-like kinase 1 (Plk1) to the central spindle in anaphase. We now find that in MKlp2 but not MKlp1-depleted cells the Aurora B–INCENP complex remains at the centromeres and fails to relocate to the central spindle. MKlp2 exerts dual control over Aurora B localization, because it is a binding partner for Aurora B, and furthermore for the phosphatase Cdc14A. Cdc14A can dephosphorylate INCENP and may contribute to its relocation to the central spindle in anaphase. We propose that MKlp2 is involved in the localization of Plk1, Aurora B, and Cdc14A to the central spindle during anaphase, and that the integration of signaling by these proteins is necessary for proper cytokinesis.
Rapid evolution of the human mutation spectrum

DNA is a remarkably precise medium for copying and storing biological information. This high fidelity results from the action of hundreds of genes involved in replication, proofreading, and damage repair. Evolutionary theory suggests that in such a system, selection has limited ability to remove genetic variants that change mutation rates by small amounts or in specific sequence contexts. Consistent with this, using SNV variation as a proxy for mutational input, we report here that mutational spectra differ substantially among species, human continental groups and even some closely-related populations. Close examination of one signal, an increased TCC→TTC mutation rate in Europeans, indicates a burst of mutations from about 15,000 to 2,000 years ago, perhaps due to the appearance, drift, and ultimate elimination of a genetic modifier of mutation rate. Our results suggest that mutation rates can evolve markedly over short evolutionary timescales and suggest the possibility of mapping mutational modifiers.
Western of Emergency Medicine: Integrating Emergency Care with Population Health and Perpetration among Youth Living in the

determine the of involving weapons in a convenience sample of service-seeking to determine the overlap between violence victimization and perpetration among these youth and the potentially shared risk factors for these We conducted this study of youth 2011 to quantify and describe high-risk behaviors and exposures in a convenience sample (N ¼ 457) of urban youth, 14–24 years of age, living on the streets or in the slums and who were participating in a Youth Development Link drop-in center for disadvantaged street youth. We computed bivariate and multivariate logistic regression analyses to determine associations between psychosocial factors and violence victimization and perpetration. Results: The overall prevalence of reporting violence victimization involving a weapon was 36%, and violence perpetration with a weapon was 19%. In terms of the overlap between victimization and perpetration, 16.6% of youth (11.6% of boys and 24.1% of girls) reported both. In multivariate analyses, parental neglect due
Dimorphic Effects of Transforming Growth Factor-&bgr; Signaling During Aortic Aneurysm Progression in Mice Suggest a Combinatorial Therapy for Marfan Syndrome

Objective— Studies of mice with mild Marfan syndrome (MFS) have correlated the development of thoracic aortic aneurysm (TAA) with improper stimulation of noncanonical (Erk-mediated) TGF&bgr; signaling by the angiotensin type I receptor (AT1r). This correlation was largely based on comparable TAA modifications by either systemic TGF&bgr; neutralization or AT1r antagonism. However, subsequent investigations have called into question some key aspects of this mechanism of arterial disease in MFS. To resolve these controversial points, here we made a head-to-head comparison of the therapeutic benefits of TGF&bgr; neutralization and AT1r antagonism in mice with progressively severe MFS (Fbn1 mgR/mgR mice). Approach and Results— Aneurysm growth, media degeneration, aortic levels of phosphorylated Erk and Smad proteins and the average survival of Fbn1 mgR/mgR mice were compared after a ≈3-month-long treatment with placebo and either the AT1r antagonist losartan or the TGF&bgr;-neutralizing antibody 1D11. In contrast to the beneficial effect of losartan, TGF&bgr; neutralization either exacerbated or mitigated TAA formation depending on whether treatment was initiated before (postnatal day 16; P16) or after (P45) aneurysm formation, respectively. Biochemical evidence-related aneurysm growth with Erk-mediated AT1r signaling, and medial degeneration with TGF&bgr; hyperactivity that was in part AT1r dependent. Importantly, P16-initiated treatment with losartan combined with P45-initiated administration of 1D11 prevented death of Fbn1 mgR/mgR mice from ruptured TAA. Conclusions— By demonstrating that promiscuous AT1r and TGF&bgr; drive partially overlapping processes of arterial disease in MFS mice, our study argues for a therapeutic strategy against TAA that targets both signaling pathways although sparing the early protective role of TGF&bgr;.
Targeting C-Reactive Protein in Inflammatory Disease by Preventing Conformational Changes

C-reactive protein (CRP) is a pentraxin that has long been employed as a marker of inflammation in clinical practice. Recent findings brought up the idea of CRP to be not only a systemic marker but also a mediator of inflammation. New studies focused on structural changes of the plasma protein, revealing the existence of two distinct protein conformations associated with opposed inflammatory properties. Native, pentameric CRP (pCRP) is considered to be the circulating precursor form of monomeric CRP (mCRP) that has been identified to be strongly proinflammatory. Recently, a dissociation mechanism of pCRP has been identified on activated platelets and activated/apoptotic cells associated with the amplification of the proinflammatory potential. Correspondingly, CRP deposits found in inflamed tissues have been identified to exhibit the monomeric conformation by using conformation-specific antibodies. Here we review the current literature on the causal role of the dissociation mechanism of pCRP and the genesis of mCRP for the amplification of the proinflammatory potential in inflammatory reactions such as atherosclerosis and ischemia/reperfusion injury. The chance to prevent the formation of proinflammatory mediators in ubiquitous inflammatory cascades has pushed therapeutic strategies by targeting pCRP dissociation in inflammation. In this respect, the development of clinically applicable derivatives of the palindromic compound 1,6-bis(phosphocholine)-hexane (1,6-bis PC) should be a major focus of future CRP research.
Four broad temperament dimensions: description, convergent validation correlations, and comparison with the Big Five

A new temperament construct based on recent brain physiology literature has been investigated using the Fisher Temperament Inventory (FTI). Four collections of behaviors emerged, each associated with a specific neural system: the dopamine, serotonin, testosterone, and estrogen/oxytocin system. These four temperament suites have been designated: (1) Curious/Energetic, (2) Cautious/Social Norm Compliant, (3) Analytical/Tough-minded, and (4) Prosocial/Empathetic temperament dimensions. Two functional magnetic resonance imaging (fMRI) studies have suggested that the FTI can measure the influence of these neural systems. In this paper, to further the behavioral validation and characterization of the four proposed temperament dimensions, we measured correlations with five variables: (1) gender; (2) level of education; (3) religious preference; (4) political orientation; (5) the degree to which an individual regards sex as essential to a successful relationship. Subjects were 39,913 anonymous members of a US Internet dating site and 70,000+ members in six other countries. Correlations with the five variables characterize the FTI and are consistent with mechanisms using the proposed neuromodulators. We also report on an analysis between the FTI and the NEO-Five Factor Inventory, using a college sample (n = 215), which showed convergent validity. The results provide novel correlates not available in other questionnaires: religiosity, political orientation, and attitudes about sex in a relationship. Also, an Eigen analysis replicated the four clusters of co-varying items. The FTI, with its broad systems and non-pathologic factors complements existing personality questionnaires. It provides an index of some brain systems that contribute to temperament, and may be useful in psychotherapy, business, medicine, and the legal community.
Phytoplankton dynamics of the Guajataca reservoir, Puerto Rico

Tropical reservoirs frequently suffer from high rates of sediment and nutrient loads (SALAS & MARTINO 200 l, WETZEL 200 l). Alloctonous nutrient inputs through runoff largely control the entrance o f nutrients and other dissolved and particulate materials; however, interna! cycling during mixis is a mechanism for the vertical transfer and exchange of nutrient through the water column. Seasonal changes in precipitation and thermal regimes are important driving factors for water column stratification and mixing pattems in the tropics (HORNE & ÜOLDMAN 1994). The excessive input of nutrients influences the structure and dynamics ofthe phytoplankton community by increasing primary production and altering species composition (CHALAR 2006). Hence, assessing the phytoplankton assemblage of a reservoir can be used as an indicator of its trophic state and overall ecological integrity (REYNOLDS 1986). There is limited information of phytoplankton diversity and temporal dynamics in tropical zones (LEWIS 1978, TuNDISI 1986, KALF & WATSON 1986, ÜONZÁLEZ & ÜRTAZ 1998), and in reservoirs ofPuerto Rico (CANDELAS-REYES 1956, JOBIN et al. 1979, ÜUINONES-MÁRQUEZ 1980, ÜARCÍA & TILLY 1982). The purpose of this research was to characterize the spatial, temporal, and vertical dynamics of the phytoplanktonic community and its relation with the water column physico-chemical characteristics.
Serotonergic modulation of spatial working memory: predictions from a computational network model

Serotonin (5-HT) receptors of types 1A and 2A are strongly expressed in prefrontal cortex (PFC) neurons, an area associated with cognitive function. Hence, 5-HT could be effective in modulating prefrontal-dependent cognitive functions, such as spatial working memory (SWM). However, a direct association between 5-HT and SWM has proved elusive in psycho-pharmacological studies. Recently, a computational network model of the PFC microcircuit was used to explore the relationship between 5-HT and SWM (Cano-Colino et al., 2013). This study found that both excessive and insufficient 5-HT levels lead to impaired SWM performance in the network, and it concluded that analyzing behavioral responses based on confidence reports could facilitate the experimental identification of SWM behavioral effects of 5-HT neuromodulation. Such analyses may have confounds based on our limited understanding of metacognitive processes. Here, we extend these results by deriving three additional predictions from the model that do not rely on confidence reports. Firstly, only excessive levels of 5-HT should result in SWM deficits that increase with delay duration. Secondly, excessive 5-HT baseline concentration makes the network vulnerable to distractors at distances that were robust to distraction in control conditions, while the network still ignores distractors efficiently for low 5-HT levels that impair SWM. Finally, 5-HT modulates neuronal memory fields in neurophysiological experiments: Neurons should be better tuned to the cued stimulus than to the behavioral report for excessive 5-HT levels, while the reverse should happen for low 5-HT concentrations. In all our simulations agonists of 5-HT1A receptors and antagonists of 5-HT2A receptors produced behavioral and physiological effects in line with global 5-HT level increases. Our model makes specific predictions to be tested experimentally and advance our understanding of the neural basis of SWM and its neuromodulation by 5-HT receptors.
Prevalence and risk factors of burnout syndrome among Spanish police officers.

BACKGROUND Police work is currently one of the most stressful occupations. High levels of stress can culminate in suffering the burnout syndrome. This syndrome is characterised by emotional exhaustion, depersonalisation and low personal accomplishment. Police officers, despite being a risk group, have been investigated less than other professional groups. The objectives of the current work are to estimate the prevalence of burnout syndrome in police officers, to present a classification of the syndrome and to identify some risk factors (socio-demographic, personality, and work-related). METHOD A cross-sectional study was carried out with 747 national police officers from Andalucía (Spain). RESULTS The prevalence of burnout is high. Furthermore, individual differences, and in particular, personality factors, are important to explain the development of burnout. CONCLUSIONS Police officers are a risk group and, therefore, actions aimed at reducing the levels of burnout among these professionals should be developed.
Addressing sampling errors and diversity loss in UMDA

Estimation of distribution algorithms replace the typical crossover and mutation operators by constructing a probabilistic model and generating offspring according to this model. In previous studies, it has been shown that this generally leads to diversity loss due to sampling errors. In this paper, for the case of the simple Univariate Marginal Distribution Algorithm (UMDA), we propose and test several methods for counteracting diversity loss. The diversity loss can come in two phases: sampling from the probability model (offspring generation) and selection. We show that it is possible to completely remove the sampling error during offspring generation. Furthermore, we examine several plausible model construction variants which counteract diversity loss during selection and demonstrate that these update rules work better than the standard update on a variety of simple test problems.
Development and impact of a computerized pediatric antiinfective decision support program.

OBJECTIVE Computerized medical decision support tools have been shown to improve the quality of care and have been cited by the Institute of Medicine as one method to reduce pharmaceutical errors. We evaluated the impact of an antiinfective decision support tool in a pediatric intensive care unit (PICU). METHODS We enhanced an existing adult antiinfective management tool by adding and changing medical logic to make it appropriate for pediatric patients. Process and outcomes measures were monitored prospectively during a 6-month control and a 6-month intervention period. Mandatory use of the decision support tool was initiated for all antiinfective orders in a 26-bed PICU during the intervention period. Clinician opinions of the decision support tool were surveyed via questionnaire. RESULTS The rate of pharmacy interventions for erroneous drug doses declined by 59%. The rate of anti-infective subtherapeutic patient days decreased by 36%, and the rate of excessive-dose days declined by 28%. The number of orders placed per antiinfective course decreased 11.5%, and the robust estimate of the antiinfective costs per patient decreased 9%. The type of anti-infectives ordered and the number of antiinfective doses per patient remained similar, as did the rates of adverse drug events and antibiotic-bacterial susceptibility mismatches. The surveyed clinicians reported that use of the program improved their antiinfective agent choices as well as their awareness of impairments in renal function and reduced the likelihood of adverse drug events. CONCLUSIONS Use of the pediatric antiinfective decision support tool in a PICU was considered beneficial to patient care by the clinicians and reduced the rates of erroneous drug orders, improved therapeutic dosage targets, and was associated with a decreased robust estimate of antiinfective costs per patient. antiinfective agents, decision support systems, drug therapy, medication errors, child, infant.
A randomized controlled trial of buprenorphine in the management of short-term ambulatory heroin withdrawal.

AIM To determine whether buprenorphine is more effective than clonidine and other symptomatic medications in managing ambulatory heroin withdrawal. DESIGN Open label, prospective randomized controlled trial examining withdrawal and 4-week postwithdrawal outcomes on intention-to-treat. SETTING Two specialist, out-patient drug treatment centres in inner city Melbourne and Sydney, Australia. PARTICIPANTS One hundred and fourteen dependent heroin users were recruited. Participants were 18 years or over, and with no significant other drug dependence, medical or psychiatric conditions or recent methadone treatment. One hundred and one (89%) participants completed a day 8 research interview examining withdrawal outcomes, and 92 (81%) completed day 35 research interview examining postwithdrawal outcomes. INTERVENTIONS Participants randomized to control (n = 56) (up to 8 days of clonidine and other symptomatic medications) or experimental (n = 58) (up to 5 days of buprenorphine) withdrawal groups. Following the 8-day withdrawal episode, participants could self-select from range of postwithdrawal options (naltrexone, substitution maintenance, or counselling). MEASUREMENTS Retention in withdrawal; heroin use during withdrawal; and retention in drug treatment 4 weeks after withdrawal. SECONDARY OUTCOMES Withdrawal severity; adverse events, and heroin use in the postwithdrawal period. FINDINGS The experimental group had better treatment retention at day 8 (86% versus 57%, P = 0.001, 95% CI for numbers needed to treat (NNT) = 3-8) and day 35 (62% versus 39%, P = 0.02, 95% CI for NNT = 4-18); used heroin on fewer days during the withdrawal programme (2.6 +/- 2.5 versus 4.5 +/- 2.3, P < 0.001, 95% CI = 1-2.5 days) and in the postwithdrawal period (9.0 +/- 8.2 versus 14.6 +/- 10, P < 0.01, 95% CI = 1.8-9.4); and reported less withdrawal severity. No severe adverse events reported. CONCLUSIONS Buprenorphine is effective for short-term ambulatory heroin withdrawal, with greater retention, less heroin use and less withdrawal discomfort during withdrawal; and increased postwithdrawal treatment retention than symptomatic medications.
Structural Features That Stabilize ZnO Clusters: An Electronic Structure Approach

We show that a simple approach to building small computationally inexpensive clusters offers insights on specific structural motifs that stabilize the electronic structure of ZnO. All-electron calculations on ZniOi needle (i = 6, 9, 12, 15, and 18) and plate (i = 9 and 18) clusters within the density functional theory (DFT) formalism show a higher stability for ZnO needles that increases with length. Puckering of the rings to achieve a more wurtzite-like structure destabilizes the needles, although this destabilization is reduced by going to infinite needles (calculated using periodic boundary conditions). Calculations of density of states (DOS) curves and band gaps for finite clusters and infinite needles highlight opportunities for band-gap tuning through kinetic control of nanocrystal growth.
NUMERICAL INVESTIGATION INTO THE DESIGN OF SHAPED DIELECTRIC LENS ANTENNAS WITH IMPROVED ANGULAR CHARACTERISTICS

The feasibility of designing a compact-size beam-switching dielectric lens antenna (DLA) with improved angular (scanning) characteristics is investigated numerically using in-house software based on the Muller boundary integral equations and hybrid genetic algorithm. It is demonstrated that joint optimization of the lens shape and feeding array parameters enables one to minimize the directivity degradation for ofi-axis feeds which is a well-known drawback of conventional extended hemielliptic DLAs fed by focal arrays. The key to success is found in proper shaping the lens proflle and using arrays of non-identical feeds.
Likelihoods and TDT for the case‐parents design

Association studies using diseased cases and their parents avoid biases due to population stratification, and the transmission/disequilibrium test (TDT) is a popular method of analysis. Sample size and power calculations for the TDT method have been reported, but often for the special situation of multiplicative effects of alleles on the genotype relative risks. Furthermore, some of the proposed calculations ignore the dependence of transmitted alleles from a pair of heterozygous parents when the effects are not multiplicative, which can lead to erroneous sample size calculations. We demonstrate how to calculate sample size and power for the TDT method for general genotype relative risks. As an alternative to the TDT method, we present likelihood methods for a variety of genotype relative risk models. Exact likelihood methods are presented to allow for accurate small‐sample analyses. We demonstrate by numerical comparisons: (1) that the TDT method is inefficient for recessive patterns of relative risks, (2) for alleles that are not rare, falsely assuming a multiplicative model can lead to gross underestimation of the required sample size for the TDT statistic, and (3) for common alleles, if the true genotype relative risks have an approximately dominant pattern, then the TDT method can be grossly inefficient compared to likelihood methods. An alternative likelihood ratio statistic, based on two degrees of freedom, tends to be robust for a wide range of genotype relative risk models. Finally, we discuss how to use standard software for conditional logistic regression to accurately assess effects of alleles as well as genotype‐environment interaction. Genet. Epidemiol. 16:250–260, 1999. © 1999 Wiley‐Liss, Inc.