Miracle-dz/UniFAR-FTUs huggingface dataset:
Propofol and Sufentanil Titration with the Bispectral Index to Provide Anesthesia for Coronary Artery Surgery

Background To provide anesthesia for cardiac surgery, hypnotics and opioids are frequently titrated on variables such as mean arterial pressure and heart rate. In this study conducted in patients scheduled to undergo coronary artery bypass grafting, propofol and sufentanil, both administered by computer-controlled infusion, were titrated on the Bispectral Index (BIS) values using a predefined algorithm. Methods After written informed consent, 110 patients, 95 men and 15 women aged 61 (9) yr [mean (SD)], were randomly allocated to receive predicted sufentanil effect site concentrations (Ce) of 0.5, 0.75, 1, 1.25, and 1.5 ng/ml, decreased by a third after sternotomy (groups 1–5). Target induction propofol concentration was 1.5 &mgr;g/ml and subsequently adjusted on BIS values. The following parameters were recorded: BIS values, predicted propofol Ce, the number of changes of propofol target, mean arterial pressure, heart rate, the number of bolus injection and doses of vasoconstrictor and vasodilator drugs, time to tracheal extubation, postoperative awareness and satisfaction scores, and cumulative morphine doses for the first postoperative day. Results One patient randomized to group 1 required 0.75 ng/ml sufentanil Ce instead of 0.5 ng/ml for increased BIS values on tracheal intubation. BIS values were similar in the five groups. The predicted propofol Ce values were different (P < 0.05; analysis of variance) among the five groups: 1.59 (0.47) to 1.23 (0.25) &mgr;g/ml in group 1 and group 4, respectively. Significantly fewer changes of propofol target were required in group 4 as compared to group 1. There were no differences among the five groups for mean arterial pressure, heart rate, time to tracheal extubation, awareness, satisfaction scores, and morphine requirements. Conclusion These results suggest the BIS, as part of an algorithm that uses both the absolute BIS value and its increase following tracheal intubation, can be used to effectively titrate both propofol and sufentanil. A predicted sufentanil Ce of 1.25 ng/ml before and 0.8 ng/ml after sternotomy was associated with the lowest predicted propofol Ce and fewer changes of propofol target. Lower sufentanil concentrations required higher propofol concentrations and more frequent changes of the target propofol concentration and were associated with similar hemodynamic tolerance.
Activity Dependent Modulation of Granule Cell Survival in the Accessory Olfactory Bulb at Puberty

The vomeronasal system (VNS) is specialized in the detection of salient chemical cues triggering social and neuroendocrine responses. Such responses are not always stereotyped, instead, they vary depending on age, sex, and reproductive state, yet the mechanisms underlying this variability are unclear. Here, by analyzing neuronal survival in the first processing nucleus of the VNS, namely the accessory olfactory bulb (AOB), through multiple bromodeoxyuridine birthdating protocols, we show that exposure of female mice to male soiled bedding material affects the integration of newborn granule interneurons mainly after puberty. This effect is induced by urine compounds produced by mature males, as bedding soiled by younger males was ineffective. The granule cell increase induced by mature male odor exposure is not prevented by pre-pubertal ovariectomy, indicating a lesser role of circulating estrogens in this plasticity. Interestingly, the intake of adult male urine-derived cues by the female vomeronasal organ increases during puberty, suggesting a direct correlation between sensory activity and AOB neuronal plasticity. Thus, as odor exposure increases the responses of newly born cells to the experienced stimuli, the addition of new GABAergic inhibitory cells to the AOB might contribute to the shaping of vomeronasal processing of male cues after puberty. Consistently, only after puberty, female mice are capable to discriminate individual male odors through the VNS.
Poland (Mainly) Chooses Stability and Continuity: The October 2011 Polish Parliamentary Election

This paper argues that the key to the centrist Civic Platform's victory in the 2011 Polish election, the first by an incumbent governing party in post-communist Poland, was its ability to generate fear about the possible consequences of the right-wing Law and Justice party returning to power. Although many of the Civic Platform's supporters were disappointed with its slow progress in modernising the country, most voters viewed the party as the better guarantor of stability at a time of crisis and continued to harbour deeply ingrained concerns about the main opposition party. The election appeared to provide further evidence of the consolidation and stabilisation of the Polish party system around the Civic Platform–Law and Justice divide. However, other factors pointed to the dangers of declaring that the Polish party system was ‘frozen’ around these two political blocs and suggested that it remained vulnerable to further shocks and re-alignments.
Modeling Tourist Flows to Indonesia and Malaysia

Summary The purpose of this study was to examine the major factors that influence the flow patterns of tourists from six important tourist-generating countries to Indonesia and Malaysia. The primary determinants included in the demand models were income, prices, and time trend. Two models that employed different indicators for the price variable were estimated; one with exchange rates in addition to relative prices, whereas the other included only an exchange rate adjusted-relative price variable. Annual time-series data covering the period 1980 to 1997 were used for estimation. The results generally indicated that the factors provide reasonably good explanations for the demand for Indonesian and Malaysian tourism. The measure of thejoint effect of the changes in exchange rates and relative prices also seems to be a better indicator for the price variable for both destination countries. The study has important marketing implications for the tourism industries in Indonesia and Malaysia.
Hyperthermophiles in the history of life

Today, hyperthermophilic (‘superheat-loving’) bacteria and archaea are found within high-temperature environments, representing the upper temperature border of life. They grow optimally above 80°C and exhibit an upper temperature border of growth up to 113°C. Members of the genera, Pyrodictium and Pyrolobus, survive at least 1 h of autoclaving. In their basically anaerobic environments, hyperthermophiles (HT) gain energy by inorganic redox reactions employing compounds like molecular hydrogen, carbon dioxide, sulphur and ferric and ferrous iron. Based on their growth requirements, HT could have existed already on the early Earth about 3.9 Gyr ago. In agreement, within the phylogenetic tree of life, they occupy all the short deep branches closest to the root. The earliest archaeal phylogenetic lineage is represented by the extremely tiny members of the novel kingdom of Nanoarchaeota, which thrive in submarine hot vents. HT are very tough survivors, even in deep-freezing at −140°C. Therefore, during impact ejecta, they could have been successfully transferred to other planets and moons through the coldness of space.
Entrepreneurship and strategy in China: why “Porter's five forces” may not be

Purpose – Challenging the suitability of “Porter's five forces” as a guide to strategy and entrepreneurship in China and in the global age at large, this paper aims to present a new “five forces” model based on Sun Tzu's timeless strategic wisdom, with entrepreneurship and “collaborative innovation” right at its heart.Design/methodology/approach – The arguments and the new model are developed, drawing on results from a survey among entrepreneurs and executives operating in China, the direct experience of top entrepreneurs, authoritative information from publishers like the Financial Times and Business Week, the consensus at the 2008 Annual Conference of the World Economic Forum, and Sun Tzu's timeless strategic insights.Findings – The survey among entrepreneurs and executives operating in China shows that “Porter's five forces” has had little impact on business practice in China. One author, a serial entrepreneur, has considered ren shi qian or three Ps (people, project and penny) as the strategic forces .
Understanding the role of the perivascular space in cerebral small vessel disease

Small vessel diseases (SVDs) are a group of disorders that result from pathological alteration of the small blood vessels in the brain, including the small arteries, capillaries and veins. Of the 35-36 million people that are estimated to suffer from dementia worldwide, up to 65% have an SVD component. Furthermore, SVD causes 20-25% of strokes, worsens outcome after stroke and is a leading cause of disability, cognitive impairment and poor mobility. Yet the underlying cause(s) of SVD are not fully understood. Magnetic resonance imaging has confirmed enlarged perivascular spaces (PVS) as a hallmark feature of SVD. In healthy tissue, these spaces are proposed to form part of a complex brain fluid drainage system which supports interstitial fluid exchange and may also facilitate clearance of waste products from the brain. The pathophysiological signature of PVS and what this infers about their function and interaction with cerebral microcirculation, plus subsequent downstream effects on lesion development in the brain has not been established. Here we discuss the potential of enlarged PVS to be a unique biomarker for SVD and related brain disorders with a vascular component. We propose that widening of PVS suggests presence of peri-vascular cell debris and other waste products that form part of a vicious cycle involving impaired cerebrovascular reactivity, blood-brain barrier dysfunction, perivascular inflammation and ultimately impaired clearance of waste proteins from the interstitial fluid space, leading to accumulation of toxins, hypoxia, and tissue damage. Here, we outline current knowledge, questions and hypotheses regarding understanding the brain fluid dynamics underpinning dementia and stroke through the common denominator of SVD.
Ear Elevation Using 2-Tiered Costal Cartilage on the Same Side as the Reconstructed Framework

Background: Ear elevation for the constructed auricle in patients with microtia is more difficult than total reconstruction of the auricle, although this procedure tends to be underestimated. Using costal cartilage for ear elevation may sometimes be difficult owing to its insufficient availability when it is harvested from the ipsilateral costal cartilage for the ear framework. We made both the ear framework and the base for elevation using only the unilateral sixth, seventh, and eighth costal cartilages to solve this problem. Our method for ear elevation is reported. Subjects and Methods: The ear elevation procedure was performed in 28 patients with unilateral microtia. A 2-stage method was used, with framework assembling of the auricle in the first stage and ear elevation of the constructed auricle in the second stage. The technique was designed to make the entire constructed framework and base cartilage for elevation using only the unilateral sixth, seventh, and eighth costal cartilages Results: All patients displayed an acceptable ear contour after the ear reconstruction procedure. There was no cartilage absorption or infection for 6 to 10 years after surgery. The auricular projections were well maintained, and the cephaloauricular angles of the constructed auricles were similar to the healthy ears at 6 to 10 years after surgery. Mean elevation was 32 degrees. Conclusions: The constructed auricle, which was made from only the costal cartilage ipsilateral to the framework, could be elevated to a mean angle of 32 degrees, and it could be maintained for 6 to 10 years. This method is an option for elevating the constructed auricle.
A theory of parties and electoral systems

Political parties and elections are the mainsprings of modern democracy. In this classic volume, Richard S. Katz explores the problem of how a given electoral system affects the role of political parties and the way in which party members are elected. He develops and tests a theory of the differences in the cohesion, ideological behavior, and issue orientation of Western parliamentary parties on the basis of the electoral systems under which they compete. A standard in the field of political theory and thought, The Theory of Parties and the Electoral System contributes to a better understanding of parliamentary party structures and demonstrates the wide utility of the rationalistic approach for explaining behavior derived from the self-interest of political actors.
Financial accounting developments in the European Union: past events and future prospects

The decision of the Commission of the European Union (EU) to oblige listed European companies, from 2005 onwards, to establish their consolidated financial statements according to IFRS (IAS) represents a preliminary peak in the internationalization process of financial accounting in Europe. The purpose of this paper is to highlight the landmarks of accounting developments in the EU since the Fourth and Seventh Directives and to reveal the obvious internationalization process of financial accounting in the EU, which has accelerated considerably during the last ten years. Owing to the considerable pressures exerted by market forces, a clear convergence of accounting practice as well as of the regulatory frameworks of the EU and its Member States with IFRS (IAS) is recognizable. The harmonization effects of the market forces on national regulators and companies appear to be much larger than those of the Fourth and Seventh Directives. In addition to the explanation and reasoning behind past developments, this paper also discusses some future prospects of financial reporting within the EU and identifies some of its major challenges.
Evaluating the Impact of Mexico's Quality Schools Program : The Pitfalls of Using Nonexperimental Data

The authors evaluate whether increasing school resources and decentralizing management decisions at the school level improves learning in a developing country. Mexico's Quality Schools Program (PEC), following many other countries and U.S. states, offers US$15,000 grants for public schools to implement five-year improvement plans that the school's staff and community design. Using a three-year panel of 74,700 schools, the authors estimate the impact of the PEC on dropout, repetition, and failure using two common nonexperimental methods-regression analysis and propensity score matching. The methods provide similar but nonidentical results. The preferred estimator, difference-in-differences with matching, reveals that participation in the PEC decreases dropout by 0.24 percentage points, failure by 0.24 percentage points, and repetition by 0.31 percentage points-an economically small but statistically significant impact. The PEC lacks measurable impact on outcomes in indigenous schools. The results suggest that a combination of increased resources and local management can produce small improvements in school outcomes, though perhaps not in the most troubled school systems.
Life Cycle Greenhouse Gas Emissions of Thin‐film Photovoltaic Electricity Generation

We present the process and the results of harmonization of greenhouse gas (GHG) emissions during the life cycle of commercial thin‐film photovoltaics (PVs), that is, amorphous silicon (a‐Si), cadmium telluride (CdTe), and copper indium gallium diselenide (CIGS). We reviewed 109 studies and harmonized the estimates of GHG emissions by aligning the assumptions, parameters, and system boundaries. During the initial screening we eliminated abstracts, short conference papers, presentations without supporting documentation, and unrelated analyses; 91 studies passed this initial screening. In the primary screening we applied rigorous criteria for completeness of reporting, validity of analysis methods, and modern relevance of the PV system studied. Additionally, we examined whether the product is a commercial one, whether the production line still exists, and whether the study's core data are original or secondary. These screenings produced five studies as the best representations of the carbon footprint of modern thin‐film PV technologies. These were harmonized through alignment of efficiency, irradiation, performance ratio, balance of system, and lifetime. The resulting estimates for carbon footprints are 20, 14, and 26 grams carbon dioxide equivalent per kilowatt‐hour (g CO2‐eq/kWh), respectively, for a‐Si, CdTe, and CIGS, for ground‐mount application under southwestern United States (US‐SW) irradiation of 2,400 kilowatt‐hours per square meter per year (kWh/m2/yr), a performance ratio of 0.8, and a lifetime of 30 years. Harmonization for the rooftop PV systems with a performance ratio of 0.75 and the same irradiation resulted in carbon footprint estimates of 21, 14, and 27 g CO2‐eq/kWh, respectively, for the three technologies. This screening and harmonization rectifies previous incomplete or outdated assessments and clarifies variations in carbon footprints across studies and amongst thin‐film technologies.
The Effect of Accounting Report Structure and Team Structure on Performance in Cross‐Functional Teams

Cross‐functional teams operate in dynamic environments in which it is difficult to properly align incentives. As a result the free‐rider problem can emerge. This paper presents two experiments in which dominant incentives to free ride were held constant. The first experiment examined the question of whether aligning accounting report structure and team structure in such a way as to create a “group frame” helps to mitigate the free‐rider problem. Accounting report structure was found to complement team structure. When properly aligned, accounting and team structures helped to resolve the free‐rider problem interactively by operating as a powerful group framing device. The second experiment provides theory‐consistent evidence that people outside the teams (subjects who acted as management control system designers) fail to appreciate how powerfully the design of accounting and team structures influence performance within teams. Finally, the study provides additional insight into the role that accounting stru.
The Effect of Work Status and Working Conditions on Mental Health in Four OECD Countries

This study aims to assess empirically whether being employed or returning to work is beneficial for all in terms of mental health, especially for those who already suffer from a longstanding illness or disability. We use longitudinal surveys from Australia, Canada, Switzerland and the UK to estimate panel data models that link decisions regarding labour market choices to health developments. To allow for state dependence of mental health, a dynamic panel model is used. The longitudinal analysis shows that non-employment generally is worse for mental health than working. The mental-health payoff to employment varies depending on the type of employment contract and working conditions. In particular, the mental health benefits for inactive individuals who obtain a non-standard job appear to be smaller than for those moving into standard employment arrangements, even after controlling for pre-existing mental health problems.
Does intensity of change matter? Factors affecting adoption of agri-environmental schemes in Spain

Agri-environmental schemes (AES) are the main policy instrument currently available in the EU to promote environmentally-friendly farming practices. However, the rate of adoption of these measures is still relatively low in southern Europe, and understanding how these rates can be increased is still an open issue. The goal of this paper is to increase that understanding by testing whether the factors which determine AES sign-up decisions are influenced by the intensity of change in farming practices that are brought about by adopting the scheme. A micro-economic model reflecting farmer AES sign-up decisions is proposed and applied to two schemes in Spain respectively requiring major or minor intensity of change in practices by surveying farmers eligible for both schemes. The results show that farm structural factors play a role when major practice change is required by the scheme, yet when dealing with minor change, individual farmer characteristics play a more determining role. Social capital and farmer attitude are important factors in both the AES surveyed. Therefore, it may be concluded that improving agronomic design would be an important tool to improve farmer participation in AES where major change is involved, whereas improved targeting and extension would help uptake for AES involving a lesser degree of change.
Technological Knowledge Assets in Industrial Firms

This research focuses on identifying and measuring the technological knowledge assets that constitute the basis of the knowledge management process and on the study of contextual factors that determine their use. To that end, a longitudinal study of 1,444 Spanish industrial firms between 1998 and 2000 was conducted using information gathered by the Survey of Business Strategies. The results enable us to identify technological knowledge assets with different levels of codification and to have a general view of how age, size and sector affect the use of those assets by Spanish industrial firms.
Integrating Methods for Developing Sustainability Indicators to Facilitate Learning and Action

Bossel's (2001) systems-based approach for deriving comprehensive indicator sets provides one of the most holistic frameworks for developing sustainability indicators. It ensures that indicators cover all important aspects of system viability, performance, and sustainability, and recognizes that a system cannot be assessed in isolation from the systems upon which it depends and which in turn depend upon it. In this reply, we show how Bossel's approach is part of a wider convergence toward integrating participatory and reductionist approaches to measure progress toward sustainable development. However, we also show that further integration of these approaches may be able to improve the accuracy and reliability of indicators to better stimulate community learning and action. Only through active community involvement can indicators facilitate progress toward sustainable development goals. To engage communities effectively in the application of indicators, these communities must be actively involved in developing, and even in proposing, indicators. The accuracy, reliability, and sensitivity of the indicators derived from local communities can be ensured through an iterative process of empirical and community evaluation. Communities are unlikely to invest in measuring sustainability indicators unless monitoring provides immediate and clear benefits. However, in the context of goals, targets, and/or baselines, sustainability indicators can more effectively contribute to a process of development that matches local priorities and engages the interests of local people.
Is There a Stabilizing Role for Fiscal Policy in the New Consensus?

Abstract This paper considers the possibility of using fiscal rather than monetary policy as the instrument of stabilization policy in a new consensus framework. Describing the conduct of fiscal policy in terms of a ‘pseudo Taylor rule’, it is shown that fiscal policy is as, if not more, effective than monetary policy as a tool for macroeconomic stabilization. The conclusion reached is that the comparative neglect of fiscal policy as an instrument of stabilization policy in new consensus macroeconomics is unwarranted.